ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	73/2098	182/18367	1.80741839156371e-23	2.02611601694292e-20	ISG15/RPS21/RPS29/RPS5/RPS17/RPS23/RPS7/RPSA/RPS27/RPS18/RPL37A/RPS3/RPL18/RPS16/RPLP0/RPS14/RPL5/RPL27A/RPL37/RPS12/RPL23/RPS4Y1/RPL7A/RPLP1/RPL23A/RPS19/MRPL12/RPL36/RPL28/RPL13A/RPL35/RPL3/RPL21/MRPS34/RPS27A/MRPS33/MRPL11/MRPL14/RPS15A/RPL10A/RPL31/MRPL20/MRPS15/RPS2/RPS9/RPLP2/RPL14/RPS6/MRPL16/MRPL51/RPS8/MRPL27/MRPL57/MRPL1/RPL7/RPL15/MRPL19/MRPL2/MRPS6/MRPS36/MRPL43/MRPS5/MRPL37/MRPL36/MRPS25/RPS20/MRPL17/RPS4X/RPS25/RPL8/MRPL47/MRPL42/MRPS21	73
GO:0045296	cadherin binding	81/2098	332/18367	1.86646689530237e-11	1.04615469481698e-08	FXYD5/FLNA/CAPG/EGFR/ITGA6/CDH1/EFHD2/STAT1/RANBP1/VASP/PDLIM1/CNN2/CTNNAL1/KRT18/CD46/CALD1/RAN/HSP90AB1/BSG/DIAPH3/ITGB1/S100A11/PAICS/HSPA5/RPL7A/TMPO/SERBP1/RPL23A/HSPA8/CNN3/NOP56/ALDOA/RDX/ARGLU1/LDHA/TRIM29/CLIC1/PSMB6/RPS2/DOCK9/RPL14/PRDX6/EPN2/LASP1/TWF2/ANK3/ANLN/SH3GLB2/PRDX1/SPTBN1/TJP1/SND1/COBLL1/BZW2/FNBP1L/WASF2/PFN1/IDH1/RPL15/YWHAE/VCL/PARK7/EZR/OLA1/DLG1/HSPA1A/EPS8L2/EIF5/PAK6/NUDC/CD2AP/LIMA1/NUMB/PICALM/CCT8/CTNND1/HDLBP/PPFIBP1/NDRG1/MPP7/SLC3A2	81
GO:0023026	MHC class II protein complex binding	17/2098	27/18367	2.46583007326083e-10	9.21398504041799e-08	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/HLA-DMA/CD74/HLA-DQB1/HLA-DMB/HLA-DQA1/HLA-DQA2/B2M/CD4/HLA-DRB5/HSP90AA1/HSP90AB1/HSPA8/YWHAE	17
GO:0005178	integrin binding	44/2098	144/18367	4.78872410895223e-10	1.34203993153386e-07	ITGB2/ISG15/LCP1/LYN/TGFBI/CD9/FERMT3/FBLN1/FN1/HMGB1/EGFR/SPP1/ITGAM/FBN1/IL1B/P4HB/ITGA4/LAMB1/GPNMB/SYK/ITGAX/JAML/TIMP2/LAMA5/ITGB1/PPIA/ITGB4/CALR/ICAM2/EMP2/ICAM1/FERMT1/CD151/ITGB5/ITGAV/JAM3/PLPP3/FERMT2/ICAM3/TSPAN4/PTN/PTK2/ITGB8/ACTN4	44
GO:0003779	actin binding	94/2098	440/18367	1.08597037685192e-09	2.43474558490201e-07	AIF1/TMSB4X/FXYD5/CXCR4/GMFG/CORO1A/MSN/S100A4/LSP1/MARCKS/LCP1/FLNA/PHACTR1/CAPG/WAS/WIPF1/FMNL1/COTL1/MYO1F/MYO1G/TMSB10/ABI3/EGFR/LRRK2/SYNE2/MYH10/P4HB/GBP1/ARPC3/VASP/PPP1R18/PDLIM1/CNN2/PARVG/CTNNAL1/RCSD1/VASH1/CALD1/DAG1/PSTPIP1/ARPC5L/DIAPH3/ITGB1/FHL3/DSTN/TNNI2/IQGAP2/CCDC88A/CNN3/ALDOA/FERMT1/PAWR/KLHL5/CAP1/RDX/SLC6A4/ACTR2/TPM3/PDLIM7/LASP1/TWF2/MYO1C/ANLN/SCIN/SPTBN1/ARPC4/COBLL1/FERMT2/ACTR3/PHACTR2/ARPC1A/WASF2/PFN1/INF2/HCLS1/EPS8/VCL/EZR/CORO1C/FGD4/EPS8L2/DMD/PALLD/RUSC1/LIMA1/MYO5A/TRIOBP/PTK2/CFL1/DAAM1/EPB41/COBL/ACTN4/MYO7A	94
GO:0023023	MHC protein complex binding	19/2098	36/18367	1.45060207360814e-09	2.71020820752455e-07	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/HLA-DMA/CD74/HLA-DQB1/HLA-DMB/HLA-DQA1/LILRB2/HLA-DQA2/B2M/LILRB1/CD4/HLA-DRB5/HSP90AA1/HSP90AB1/HSPA8/YWHAE	19
GO:0003697	single-stranded DNA binding	38/2098	123/18367	5.11101782588751e-09	8.18492997545699e-07	SAMHD1/HMGB1/MCM7/HMGB2/HSPD1/MCM3/MCM5/RPA3/MCM6/NUCKS1/SMC2/RAD51AP1/RAD51/MCM4/RTF1/HNRNPA1/SMC4/MSH2/RPA2/MCM2/MCM10/SMARCA1/BLM/POLR2H/BRCA2/CDC45/RAD50/RPA1/HNRNPA2B1/POLA1/ERCC1/RAD23B/RBBP8/NME1/LRPPRC/WBP11/PURA/YBX1	38
GO:0008022	protein C-terminus binding	50/2098	189/18367	7.90380569929239e-09	1.10752077361335e-06	CORO1A/NCF2/FBLN1/FN1/JAK2/PCNA/TNFAIP3/PABPC1/TOP2A/MKI67/CIITA/CSK/CENPF/BCAM/MAD2L1/PTK2B/RAD51/ID1/PHB2/MSH2/HRAS/CIB1/ITGB3BP/TOPBP1/PRDX3/MYO1C/SDCBP/BRCA2/MID1IP1/XRCC5/YAP1/PHB/SIAH1/XRCC6/SAE1/NCL/EZR/DLG1/ERCC1/TOP2B/AGO2/COIL/TBL1X/CD2AP/YEATS4/GPSM2/EPB41/MDC1/PPARG/DYNLT1	50
GO:0008094	ATP-dependent activity, acting on DNA	35/2098	111/18367	1.13074500400882e-08	1.40840572165988e-06	MCM7/HELLS/MCM3/MCM5/MCM6/TOP2A/SMC3/RAD51/RFC3/MCM4/RFC4/RFC2/ATAD5/MSH2/RBBP4/MCM2/RAD51C/MSH6/RFC1/SMARCA1/BLM/DSCC1/CHD9/XRCC5/RAD50/SMARCA2/XRCC6/DDX1/TOP2B/POLQ/ASCC3/TTF2/HLTF/SMARCA5/XRCC2	35
GO:0035325	Toll-like receptor binding	10/2098	12/18367	1.96875197761414e-08	2.20697096690545e-06	S100A8/LY96/TLR2/TLR1/CD36/TLR6/SYK/S100A9/UNC93B1/MYD88	10
GO:0051082	unfolded protein binding	36/2098	122/18367	4.84007248297821e-08	4.93247386674416e-06	HSP90B1/LMAN1/HSPD1/PFDN5/HSP90AA1/HSP90AB1/TUBB4B/PPIA/PPIB/CALR/NPM1/HSPE1/HSPA5/SERPINH1/HSPA8/HSPA6/TAPBP/TCP1/CCT6A/CHAF1A/SRSF10/CCT2/NUDCD2/AFG3L2/HSPA14/HSPA1A/NUDC/CCT4/SIL1/PFDN1/NACA/TRAP1/NAP1L4/CCT8/HSPA9/ST13	36
GO:0140097	catalytic activity, acting on DNA	54/2098	229/18367	1.40688414852616e-07	1.31426427541485e-05	PCNA/MCM7/HELLS/ISG20/MCM3/MCM5/RPS3/MCM6/FEN1/TOP2A/DNMT1/UNG/SMC3/RAD51/RFC3/MCM4/RFC4/RFC2/ATAD5/MSH2/LIG1/RBBP4/MCM2/RAD51C/MSH6/RFC1/SMARCA1/BLM/POLD3/DSCC1/CHD9/POLE3/XRCC5/RAD50/SMARCA2/DNASE1L1/XRCC6/POLA1/APEX1/POLD4/MGME1/DDX1/ERCC1/TOP2B/POLQ/ASCC3/RBBP8/NME1/TTF2/HLTF/EXO1/POLE2/SMARCA5/XRCC2	54
GO:0044389	ubiquitin-like protein ligase binding	68/2098	316/18367	1.62622186851527e-07	1.40230362661971e-05	LAPTM5/TXNIP/CXCR4/ISG15/TNFRSF1B/LYN/UBE2L6/EGFR/TUBA1B/TNFRSF14/TUBB/HSPD1/STAT1/PA2G4/CEBPB/UBE2T/ARRB2/JAK1/NFKBIA/HSP90AA1/HSP90AB1/RPL5/SLC25A5/PARP9/CALR/RPL23/PTK2B/HSPA5/BRCA1/NAE1/UBE2C/UBB/HSPA8/RPA2/PSMA3/TRIB1/HSPA6/PSMD1/STAT2/RPS27A/TCP1/PRDX6/CACYBP/UBE2D1/RALB/NEDD8/CCT2/BAG2/XRCC5/DTX3L/YWHAE/JUN/VCL/FANCL/HSPA1A/CDKN1A/DDX58/RNF8/TRIM28/VCP/UBASH3B/LRPPRC/GABARAP/SMAD5/TRIOBP/HSPA9/UBE2N/HLTF	68
GO:0009055	electron transfer activity	35/2098	126/18367	3.77489918744177e-07	3.02261570651588e-05	CYBB/NCF2/CYBA/NCF1/ALDH2/COX6A1/CYB5A/AKR7A2/ADH5/GLDC/NDUFA10/DEGS1/ASPH/ETFB/NDUFB9/AKR1B1/NDUFB4/NDUFB7/NDUFA6/ETFA/COX7A2/NDUFV1/NDUFS8/NDUFV2/CYC1/UQCR10/QDPR/NDUFS6/COX5A/UQCRFS1/NDUFC2/NDUFA13/NDUFB10/SDHA/NDUFA8	35
GO:0140375	immune receptor activity	38/2098	144/18367	5.09839025512119e-07	3.8101969839939e-05	FCER1G/HLA-DPA1/HLA-DRA/HLA-DRB1/CD74/CXCR4/FPR1/CD44/HLA-DQB1/HLA-DQA1/C5AR1/FPR3/LILRB2/HLA-DQA2/C3AR1/LILRB1/LILRB3/IL10RA/CD4/FCGR1B/CCR1/CCR2/LILRA2/CTSH/IL2RG/IFNGR2/IL27RA/LILRA6/LILRA5/CCRL2/IL6R/CX3CR1/IL13RA1/CSF2RB/IL6ST/IL17RA/CSF2RA/IFNGR1	38
GO:0001618	virus receptor activity	25/2098	76/18367	5.56708871367609e-07	3.90044153001931e-05	CXCR4/CD86/EGFR/ITGA5/CD4/TNFRSF14/CLEC5A/SIVA1/RPSA/SELPLG/CD46/DAG1/BSG/CDK1/ITGB1/DPP4/ICAM1/ITGB5/SLC1A5/ANPEP/ITGAV/PLSCR1/SLC52A1/HSPA1A/TFRC	25
GO:0042605	peptide antigen binding	16/2098	36/18367	6.15278620508014e-07	4.05721960934991e-05	HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/HLA-C/HLA-F/HLA-DQB1/HLA-DQA1/HLA-E/HLA-DRB5/TAP2/TAP1/DHCR24/TAPBP	16
GO:0033218	amide binding	79/2098	400/18367	7.12622922054463e-07	4.33990538230734e-05	HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/ITGB2/CD14/CD74/HLA-C/HLA-F/HLA-DQB1/HLA-DQA1/MSR1/SORL1/LILRB2/HLA-E/CRIP1/CST3/TLR2/PSAP/TYMS/TLR1/ITGAM/HLA-DRB5/TAP2/TLR4/CD36/CD300LF/TAP1/PFDN5/LRPAP1/SLC40A1/TLR6/NFKBIA/HSP90AB1/MME/PPIA/CD1D/PPIB/CALR/TREM2/C1QA/DBI/PPIC/DHCR24/DHFR/MARCO/CTSV/NUP214/ACBD6/ACADVL/PHB2/ENPEP/TPP1/FKBP5/ITM2C/KPNB1/TAPBP/ANPEP/FKBP3/FOLR1/SLC19A1/CLTA/MGST1/VDAC1/IGF1R/IPO5/ECI2/FKBP1A/PTGES/PFDN1/INSR/PICALM/AP2M1/CLSTN1/KDELR2/LDLRAP1/PPARG	79
GO:0140272	exogenous protein binding	25/2098	77/18367	7.35577183441923e-07	4.33990538230734e-05	CXCR4/CD86/EGFR/ITGA5/CD4/TNFRSF14/CLEC5A/SIVA1/RPSA/SELPLG/CD46/DAG1/BSG/CDK1/ITGB1/DPP4/ICAM1/ITGB5/SLC1A5/ANPEP/ITGAV/PLSCR1/SLC52A1/HSPA1A/TFRC	25
GO:0050786	RAGE receptor binding	8/2098	10/18367	1.04138262763249e-06	5.83694962788009e-05	S100A8/S100A4/FPR1/S100A12/HMGB1/HMGB2/S100A9/S100A13	8
GO:0038187	pattern recognition receptor activity	13/2098	26/18367	1.33868780047465e-06	7.14604297300994e-05	CD14/FCN1/CLEC7A/LY96/TLR2/CLEC4E/TLR4/COLEC12/CD36/PTAFR/TLR7/MARCO/TLR8	13
GO:0031625	ubiquitin protein ligase binding	62/2098	297/18367	1.66378654611087e-06	8.47774871904673e-05	LAPTM5/TXNIP/CXCR4/ISG15/TNFRSF1B/LYN/UBE2L6/EGFR/TUBA1B/TNFRSF14/TUBB/HSPD1/PA2G4/UBE2T/ARRB2/JAK1/NFKBIA/HSP90AA1/HSP90AB1/RPL5/SLC25A5/CALR/RPL23/PTK2B/HSPA5/BRCA1/NAE1/UBB/HSPA8/RPA2/PSMA3/TRIB1/HSPA6/PSMD1/RPS27A/TCP1/PRDX6/CACYBP/UBE2D1/RALB/NEDD8/CCT2/BAG2/XRCC5/YWHAE/JUN/VCL/FANCL/HSPA1A/CDKN1A/DDX58/RNF8/TRIM28/VCP/UBASH3B/LRPPRC/GABARAP/SMAD5/TRIOBP/HSPA9/UBE2N/HLTF	62
GO:0017116	single-stranded DNA helicase activity	12/2098	23/18367	1.92548779382793e-06	9.38466007339613e-05	MCM7/MCM3/MCM5/MCM6/RAD51/RFC3/MCM4/RFC4/RFC2/MCM2/DSCC1/POLQ	12
GO:0044183	protein folding chaperone	16/2098	40/18367	3.3830726025353e-06	0.000158017682810086	CD74/HSP90AB1/CALR/CCDC47/HSPA5/HSPA8/HSPA6/TCP1/CCT6A/CCT2/HSPA14/HSPA1A/CCT4/PFDN1/CCT8/HSPA9	16
GO:0003684	damaged DNA binding	22/2098	68/18367	3.58529452264848e-06	0.000160764606395558	HMGB1/PCNA/HMGB2/RPS3/RPA3/FEN1/UNG/BRCA1/MSH2/RPA2/MSH6/DDB1/BLM/XRCC5/PNKP/RPA1/XRCC6/APEX1/ERCC1/RAD23B/POLQ/RBBP8	22
GO:0042277	peptide binding	64/2098	321/18367	5.71036238491394e-06	0.00024620447051879	HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/ITGB2/CD14/CD74/HLA-C/HLA-F/HLA-DQB1/HLA-DQA1/MSR1/SORL1/LILRB2/HLA-E/CRIP1/CST3/TLR2/TLR1/ITGAM/HLA-DRB5/TAP2/TLR4/CD36/TAP1/PFDN5/LRPAP1/SLC40A1/TLR6/NFKBIA/HSP90AB1/MME/PPIA/CD1D/PPIB/CALR/TREM2/C1QA/PPIC/DHCR24/MARCO/CTSV/NUP214/ENPEP/TPP1/ITM2C/KPNB1/TAPBP/ANPEP/CLTA/MGST1/IGF1R/IPO5/PTGES/PFDN1/INSR/PICALM/AP2M1/CLSTN1/KDELR2/LDLRAP1/PPARG	64
GO:0042393	histone binding	51/2098	244/18367	1.29665719936336e-05	0.000536730243790577	NASP/JAK2/CTSL/MORC4/STAT1/DEK/RBBP7/DNAJC9/CKS1B/ATAD2/CD1D/PARP9/NPM1/CBX5/VRK1/ASF1B/PRKCB/SET/NAP1L1/RBBP4/MCM2/MSH6/HAT1/CKS2/BAZ1B/USP15/SUZ12/BRD7/NCAPD3/SMARCC1/CBX4/BRD4/SSRP1/TRIM24/SMARCA2/USP3/KDM1B/DTX3L/KMT2E/IPO7/TBL1X/RNF8/ING2/UHRF1/YEATS4/NAP1L4/SAMD1/PWP1/PKN1/SMARCA5/NCAPG2	51
GO:0019843	rRNA binding	21/2098	68/18367	1.34062861963748e-05	0.000536730243790577	RPS5/RPS18/RPS3/RPLP0/RPS14/RPL5/RPL37/RPL23/NPM1/RPS4Y1/RPL23A/MRPL11/MRPL20/RPS9/MRPL16/IMP3/MRPS6/SBDS/BRIX1/RPS4X/RPL8	21
GO:0035173	histone kinase activity	9/2098	16/18367	1.75565236954636e-05	0.000678650450434991	JAK2/CDK1/VRK1/PRKCB/CHEK1/BAZ1B/CDK2/AURKB/PKN1	9
GO:0000217	DNA secondary structure binding	14/2098	36/18367	2.0290437880896e-05	0.000758186028816149	MEF2C/HMGB1/HMGB2/CLSPN/RAD51AP1/MSH2/RAD51C/MSH6/BLM/HMGA1/HNRNPD/HMGB3/RBBP8/XRCC2	14
GO:0042288	MHC class I protein binding	10/2098	20/18367	2.31273231957651e-05	0.000836313848466214	LILRB2/HLA-E/PILRA/LILRB1/TUBB/TAP2/TAP1/TUBB4B/TAPBP/VCP	10
GO:0043236	laminin binding	12/2098	28/18367	2.50279874014716e-05	0.000876761683657801	CTSS/LGALS1/ITGA6/TINAGL1/RPSA/DAG1/ITGB1/LGALS3/BCAM/PLEKHA2/GPC1/ADGRG6	12
GO:0019955	cytokine binding	33/2098	139/18367	3.0919472847605e-05	0.00105032512309592	CD74/CXCR4/TNFRSF1B/ZFP36/CSF1R/IL10RA/PLP2/HMGB1/CD4/TNFRSF14/CCR1/CD36/GBP1/ITGA4/IL1RN/CCR2/NRP2/IL2RG/IL27RA/ITGB1/ENG/CCRL2/IL6R/CX3CR1/NRP1/LTBP1/IL13RA1/IL6ST/ITGAV/CSF2RA/PARK7/IFNGR1/TGFBR3	33
GO:0038024	cargo receptor activity	22/2098	77/18367	3.28770119501006e-05	0.00108397442341361	ITGB2/MSR1/SORL1/ASGR1/ITGAM/LRP2/COLEC12/CXCL16/CD36/OLR1/APOBR/MARCO/CD163/STAB1/ASGR2/SCARA3/LGALS3BP/FOLR1/PRSS12/TFRC/INSR/CD320	22
GO:0004298	threonine-type endopeptidase activity	8/2098	14/18367	4.54544519423818e-05	0.00145584116078314	PSMB9/PSMB8/PSMB2/PSMB5/PSMB6/PSMB1/PSMB10/PSMB7	8
GO:0003725	double-stranded RNA binding	21/2098	74/18367	5.50072272517148e-05	0.00171286393747701	VIM/MSN/MTDH/OAS2/HMGB1/TUBA1B/OASL/HSPD1/TLR7/HSP90AB1/TUBB4B/OAS1/TLR8/STAU1/NLRP1/MBNL1/DDX1/DDX58/AGO2/TFRC/SLC3A2	21
GO:0051020	GTPase binding	56/2098	291/18367	6.00719143828229e-05	0.00181212771652824	NCF2/LCP1/ARHGDIB/FLNA/WAS/SORL1/FMNL1/RASSF5/LRRK2/FGD2/RANBP1/DOCK4/HSP90AA1/SOD1/DIAPH3/IQGAP2/RASA1/BIRC5/RHOBTB3/LSM2/KPNB1/DMXL2/CIB1/CSE1L/RIN3/GOLGA4/NXT1/FGD3/MYO1C/CLTA/SPTBN1/RAP1A/RANBP17/STOML2/FNBP1L/PFN1/INF2/EPS8/ECT2/ARHGEF2/CORO1C/FGD4/IPO5/IPO7/BNIP3/DOCK11/PICALM/MYO5A/TRIOBP/DAAM1/NDRG1/PKN1/YBX1/CCDC186/RTKN/KNTC1	56
GO:0003714	transcription corepressor activity	40/2098	187/18367	6.23304580176056e-05	0.00181212771652824	TRIM22/GMNN/PA2G4/PFDN5/SRSF2/PARP9/CCND1/BTG2/EZH2/PAWR/C1QBP/TFAP2A/SIAH2/SF1/BRD7/CBX4/NCOR2/YAP1/CASP8AP2/PHB/EID1/KMT5A/APEX1/HSPA1A/HSBP1L1/PARP14/FHL2/TLE1/RERE/TBL1X/ZNF451/RBBP8/TRIM28/EID2/DRAP1/BASP1/KCTD1/ARID5A/RCOR1/URI1	40
GO:0140297	DNA-binding transcription factor binding	71/2098	394/18367	6.30445860344348e-05	0.00181212771652824	SPI1/MTDH/MEF2C/HMGB1/FOS/ACTB/KLF4/PCNA/LMO2/OASL/FBP1/NR4A2/PARP1/STAT1/GMNN/CEBPB/RPS3/FUS/MEF2A/NFKBIA/NLRP3/CIITA/CENPF/HHEX/PARP9/CALR/NPM1/CBX5/NR4A1/IFI27/PRKCB/PHB2/HMGN3/CXXC5/ISL1/NOTCH2/STAT3/HDAC2/HMGA1/VDR/BHLHE40/TRIM24/NCOR2/YAP1/KLF5/CDKN2A/DTX3L/CHCHD2/NFYB/COMMD7/HCLS1/FOXO4/JUN/APEX1/TACC2/PARK7/FHL2/ID2/RBBP8/BHLHE41/TBX3/TRIP6/PURA/PKN1/COMMD6/MAPK14/ASXL1/ACTN4/ARID5A/PPARG/NCAPG2	71
GO:0042162	telomeric DNA binding	13/2098	36/18367	9.8836818939504e-05	0.0027699018507796	HNRNPA1/RPA2/BLM/HNRNPD/UPF3A/XRCC5/RAD50/RPA1/XRCC6/NCL/HNRNPA2B1/APEX1/PURA	13
GO:0051015	actin filament binding	44/2098	217/18367	0.00010413846577969	0.00284729805217153	AIF1/CORO1A/MARCKS/LCP1/FLNA/CAPG/FMNL1/COTL1/MYO1F/MYO1G/ABI3/EGFR/SYNE2/MYH10/ARPC3/CTNNAL1/RCSD1/PSTPIP1/ARPC5L/DSTN/IQGAP2/FERMT1/SLC6A4/ACTR2/TPM3/LASP1/TWF2/MYO1C/SCIN/SPTBN1/ARPC4/FERMT2/ACTR3/ARPC1A/HCLS1/EZR/CORO1C/DMD/LIMA1/MYO5A/TRIOBP/CFL1/ACTN4/MYO7A	44
GO:0050840	extracellular matrix binding	17/2098	56/18367	0.000110698465657534	0.00295459476195465	CTSS/LGALS1/TGFBI/SPP1/VEGFA/ITGA6/TINAGL1/ADGRG1/RPSA/DAG1/ITGB1/LGALS3/BCAM/PLEKHA2/ITGAV/GPC1/ADGRG6	17
GO:0001540	amyloid-beta binding	22/2098	84/18367	0.00013753166761658	0.0035854185906555	ITGB2/CD74/MSR1/SORL1/LILRB2/CST3/TLR2/ITGAM/TLR4/CD36/PFDN5/LRPAP1/TLR6/TREM2/C1QA/MARCO/ITM2C/PFDN1/INSR/PICALM/CLSTN1/LDLRAP1	22
GO:0019902	phosphatase binding	40/2098	196/18367	0.000181870387112467	0.0046289001564043	PHACTR1/LILRB2/LILRB1/LILRB4/EGFR/HSP90B1/STAT1/PPP1R18/MET/JAK1/CARHSP1/STAT6/SYK/SOD1/CSK/LGALS3/SIGLEC10/KCNQ1/CD33/SH2D4A/RPA2/STAU1/SPHK1/STAT3/SH3YL1/PARD3/SIRPA/GRB2/KCNN4/SLC9A1/MASTL/MVP/DLG1/BAD/PPP1R15A/ENSA/VCP/PTK2/MAPK14/PPP1R35	40
GO:0044325	transmembrane transporter binding	30/2098	133/18367	0.00018581668781284	0.0046289001564043	TSPO/FLNA/PYCARD/LYN/SLC8A1/LRRK2/TCAF1/HSP90AB1/KCNAB2/KCNQ1/CAMK2D/KCNE3/S100A10/CALM2/CIB1/USP10/ANK3/BAG2/VDAC1/GOPC/YWHAE/PHPT1/DLG1/FKBP1A/YES1/ID2/AKAP9/AP2M1/HOMER1/ACTN4	30
GO:0016504	peptidase activator activity	14/2098	43/18367	0.000193521400912891	0.00471603240050762	PYCARD/FBLN1/FN1/CASP1/APP/CTSH/PSME2/NLRP12/PCOLCE2/NLRP1/PSMD14/CASP8AP2/BAD/VCP	14
GO:0140678	molecular function inhibitor activity	29/2098	128/18367	0.000217716643092601	0.00518343642338229	TXNIP/LRRK2/OAZ1/RPS7/RPL5/RPL37/NOTCH1/PARP9/RPL23/ID1/RASA1/CAMK2D/ANXA5/APOC1/CALM2/FBXO5/ID3/ID4/ANXA3/DTX3L/PHPT1/COMMD1/ENSA/ID2/RPS20/GCHFR/PACSIN3/PURA/NCAPG2	29
GO:0030246	carbohydrate binding	51/2098	271/18367	0.000221949106442774	0.00518343642338229	HLA-DRA/HLA-DRB1/LGALS1/FCN1/VCAN/CLEC2B/LGALS9/CLEC7A/LGALS2/ASGR1/SLC2A3/CLEC12A/CD69/CLEC4E/CLEC5A/FBP1/COLEC12/LMAN1/CLEC4A/OLR1/GPCPD1/AGL/BSG/GALNT11/LGALS3/ENG/SIGLEC10/CD93/CALR/HK3/SIGLEC1/SIGLEC9/CD33/HK2/ASGR2/SIGLEC7/CD302/ALDOA/MLEC/FBXO6/RPIA/FUOM/GANAB/CHID1/UGP2/GAA/SELL/PLOD2/CDIPT/P3H1/GALNT18	51
GO:0001784	phosphotyrosine residue binding	14/2098	44/18367	0.000254267165617466	0.00581701005422814	HCK/FGR/SH3BP2/SOCS3/SYK/PTPN6/SAMSN1/VAV1/RASA1/GRB2/PFN1/YES1/PTPN3/LDLRAP1	14
GO:0000400	four-way junction DNA binding	8/2098	17/18367	0.000268091618781334	0.00601061409307752	HMGB1/HMGB2/MSH2/RAD51C/MSH6/BLM/HMGB3/XRCC2	8
GO:0031491	nucleosome binding	19/2098	71/18367	0.000284378330569844	0.00625074722683911	ACTB/SUPT16H/VRK1/HMGN2/HMGN3/RBBP4/SMARCA1/HDAC2/SMARCC1/SSRP1/PARP2/HMGN1/UHRF1/NAP1L4/ACTL6A/MBD2/ACTR6/MBD3/SMARCA5	19
GO:0032395	MHC class II receptor activity	6/2098	10/18367	0.000307737760408073	0.00663411595033558	HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DQA2	6
GO:0042287	MHC protein binding	13/2098	40/18367	0.000332071444806553	0.00689355721533603	CD74/CLEC7A/LILRB2/HLA-E/PILRA/LILRB1/CD4/TUBB/TAP2/TAP1/TUBB4B/TAPBP/VCP	13
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	13/2098	40/18367	0.000332071444806553	0.00689355721533603	PYCARD/CASP1/CTSH/PRDX5/NAIP/BIRC5/NLRP12/BIRC3/NLRP1/RPS6KA1/PRDX3/CASP8AP2/BAD	13
GO:0019903	protein phosphatase binding	32/2098	150/18367	0.000339682253488713	0.00691636545902145	PHACTR1/LILRB2/LILRB1/LILRB4/EGFR/HSP90B1/STAT1/MET/JAK1/STAT6/SOD1/CSK/LGALS3/KCNQ1/CD33/RPA2/STAU1/SPHK1/STAT3/PARD3/SIRPA/GRB2/KCNN4/SLC9A1/MASTL/MVP/BAD/PPP1R15A/ENSA/VCP/PTK2/MAPK14	32
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	19/2098	72/18367	0.000345509782074221	0.00691636545902145	COX6A1/CYB5A/NDUFA10/NDUFB9/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/CYC1/UQCR10/NDUFS6/COX5A/UQCRFS1/NDUFC2/NDUFA13/NDUFB10/NDUFA8	19
GO:0003712	transcription coregulator activity	81/2098	489/18367	0.000361672711782719	0.00711289666506014	MTDH/PAGE4/TRIM22/HMGB1/LMO2/HMGB2/GMNN/PA2G4/MAGED1/PDLIM1/PFDN5/FUS/NUCKS1/CIITA/SRSF2/FHL3/PSIP1/NOTCH1/PARP9/NPM1/CCND1/VGLL1/BRCA1/PRKCB/BTG2/EZH2/BTG1/PAWR/C1QBP/TFAP2A/RBPMS/SIAH2/PTPN14/SF1/HMGA1/BRD7/SMARCC1/CBX4/BRD4/TRIM24/NCOR2/YAP1/SMARCA2/CASP8AP2/PSMC3IP/SND1/TRIM38/PMF1/PHB/ARID5B/EID1/USP22/KMT5A/APEX1/PARK7/DDX1/HSPA1A/HSBP1L1/PARP14/ARID3A/FHL2/TLE1/RERE/TBL1X/MYCBP/CENPJ/ZNF451/RBBP8/TRIM28/EID2/ACTL6A/DRAP1/BASP1/PKN1/KCTD1/ASXL1/ACTN4/DCAF6/ARID5A/RCOR1/URI1	81
GO:0045309	protein phosphorylated amino acid binding	16/2098	56/18367	0.000378304302591109	0.00731170902076955	HCK/FGR/SH3BP2/SOCS3/SYK/PTPN6/SAMSN1/VAV1/RTF1/RASA1/GRB2/PFN1/YWHAE/YES1/PTPN3/LDLRAP1	16
GO:0097110	scaffold protein binding	18/2098	67/18367	0.000386513352151959	0.00734375369088723	VIM/LYN/PSAP/TREM1/DSP/KRT18/HSP90AA1/SYK/TREM2/KCNQ1/CD163/KRT8/DYNLL2/IL6ST/TCOF1/XRCC6/YWHAE/PARK7	18
GO:0061134	peptidase regulator activity	44/2098	230/18367	0.000402275504132803	0.00751584733554787	TIMP1/SERPINA1/BST2/PYCARD/CST3/FBLN1/ITIH5/FN1/SPINT1/SPINT2/CASP1/PEBP1/SERPINF1/APP/C3/CTSH/PRDX5/CARD16/APLP2/TIMP2/TIMP3/CRIM1/CST6/PSME2/SERPINH1/NAIP/CSTB/BIRC5/NLRP12/BIRC3/PCOLCE2/NLRP1/RPS6KA1/PRDX3/PSMD14/CSTA/USP14/CASP8AP2/BAD/SERPINB8/VCP/SERPING1/GAPDH/GPC3	44
GO:0097718	disordered domain specific binding	12/2098	36/18367	0.000430189459296164	0.00790561285034425	FN1/RRM1/HSP90AA1/HSP90AB1/GJA1/GJA5/CALM2/EZR/HSPA1A/AP2M1/AP2A2/GAPDH	12
GO:0019838	growth factor binding	30/2098	141/18367	0.000536855147060404	0.00965282146721047	IL10RA/DUSP1/EGFR/ITGA6/LRP2/CD36/IL1RN/NRP2/IL2RG/ENG/ITGB4/CRIM1/IL6R/RHBDF2/FLT1/RPS19/NRP1/LTBP1/RPS2/IL6ST/ITGAV/SDCBP/COL4A1/GPC1/IGF1R/INSR/TGFBR3/PTN/PDGFA/S100A13	30
GO:0008047	enzyme activator activity	25/2098	110/18367	0.00054632729308121	0.00965282146721047	GMFG/CCL3/NCF2/NCF1/PSAP/ALOX5AP/GNAS/BTK/DDOST/NCF4/APOC1/RFC1/CALM2/SUZ12/PDCD5/XRCC5/PSMC3IP/DBF4/DTX3L/SAE1/PARK7/MMP15/DPM2/ARL1/NCAPG2	25
GO:0030515	snoRNA binding	11/2098	32/18367	0.000551097746566878	0.00965282146721047	ISG20/PRKDC/NOP56/NHP2/NOP58/SNU13/XRCC5/NUDT4/IMP3/NUDT5/BMS1	11
GO:0008137	NADH dehydrogenase (ubiquinone) activity	13/2098	42/18367	0.000565984306198694	0.00976105241921132	NDUFA10/NDUFB9/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	13
GO:0019864	IgG binding	6/2098	11/18367	0.000611506618606102	0.0103863472645067	FCER1G/FCGR3A/FCGRT/FCGR2A/FCGR1A/FCGR1B	6
GO:0001846	opsonin binding	7/2098	15/18367	0.000702643832035517	0.0117561751598778	ITGB2/ITGAM/CD93/CALR/C1QBP/ITGAV/PHB	7
GO:0050136	NADH dehydrogenase (quinone) activity	13/2098	43/18367	0.00072738489848921	0.0119146566866446	NDUFA10/NDUFB9/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	13
GO:0019956	chemokine binding	11/2098	33/18367	0.000742126428032814	0.0119146566866446	CXCR4/ZFP36/PLP2/HMGB1/CCR1/ITGA4/CCR2/ITGB1/CCRL2/CX3CR1/ITGAV	11
GO:0051219	phosphoprotein binding	21/2098	88/18367	0.00075113782756146	0.0119146566866446	LYN/HCK/FGR/SH3BP2/SOCS3/SYK/PTPN6/SAMSN1/VAV1/RTF1/RASA1/CBX4/GRB2/PFN1/YWHAE/YES1/PTPN3/UBASH3B/EPB41/LDLRAP1/URI1	21
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	53/2098	299/18367	0.00075463035214252	0.0119146566866446	SPI1/MTDH/FOS/ACTB/KLF4/PCNA/LMO2/OASL/FBP1/NR4A2/PARP1/STAT1/CEBPB/FUS/MEF2A/NFKBIA/PARP9/CALR/NPM1/NR4A1/IFI27/PRKCB/PHB2/HMGN3/ISL1/NOTCH2/STAT3/HDAC2/HMGA1/VDR/BHLHE40/TRIM24/NCOR2/CDKN2A/DTX3L/COMMD7/HCLS1/JUN/APEX1/TACC2/PARK7/ID2/RBBP8/BHLHE41/TBX3/TRIP6/PKN1/COMMD6/MAPK14/ASXL1/ACTN4/ARID5A/PPARG	53
GO:0016763	pentosyltransferase activity	14/2098	49/18367	0.000862879830965948	0.013422908238692	TYMP/UPP1/PARP1/NAMPT/QPRT/PARP9/MTAP/UMPS/PNP/PARP2/GXYLT1/PARP14/PARP12/PPAT	14
GO:0031267	small GTPase binding	47/2098	259/18367	0.000874105532046845	0.013422908238692	NCF2/ARHGDIB/FLNA/WAS/SORL1/FMNL1/RASSF5/LRRK2/FGD2/RANBP1/DOCK4/SOD1/DIAPH3/IQGAP2/BIRC5/RHOBTB3/LSM2/KPNB1/DMXL2/CIB1/CSE1L/RIN3/GOLGA4/NXT1/FGD3/MYO1C/RAP1A/RANBP17/PFN1/INF2/EPS8/ECT2/ARHGEF2/CORO1C/FGD4/IPO5/IPO7/DOCK11/PICALM/MYO5A/TRIOBP/DAAM1/NDRG1/PKN1/CCDC186/RTKN/KNTC1	47
GO:0005080	protein kinase C binding	15/2098	55/18367	0.000974007632622654	0.0146621326993512	MARCKS/PLEK/FLNA/HINT1/DSP/TOP2A/SRSF2/PRKCB/CCDC88A/C1QBP/ITGAV/TWF2/PARD6B/TOP2B/PKN1	15
GO:0003678	DNA helicase activity	18/2098	72/18367	0.000980963383096648	0.0146621326993512	MCM7/MCM3/MCM5/MCM6/RAD51/RFC3/MCM4/RFC4/RFC2/MCM2/BLM/DSCC1/CHD9/XRCC5/RAD50/XRCC6/POLQ/ASCC3	18
GO:0032396	inhibitory MHC class I receptor activity	6/2098	12/18367	0.00110494621880096	0.0162979567273141	LILRB2/LILRB1/LILRB3/LILRA2/LILRA6/LILRA5	6
GO:0003688	DNA replication origin binding	7/2098	16/18367	0.00112648591352184	0.0163603216041243	HSPD1/MCM5/CDC6/MCM2/MCM10/CDC45/POLA1	7
GO:0003954	NADH dehydrogenase activity	13/2098	45/18367	0.00116755194320245	0.0163603216041243	NDUFA10/NDUFB9/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	13
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	13/2098	45/18367	0.00116755194320245	0.0163603216041243	NDUFA10/NDUFB9/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	13
GO:0004715	non-membrane spanning protein tyrosine kinase activity	13/2098	45/18367	0.00116755194320245	0.0163603216041243	LYN/HCK/FGR/JAK2/BTK/JAK1/SYK/CSK/PTK2B/WEE1/BAZ1B/YES1/PTK2	13
GO:0005126	cytokine receptor binding	48/2098	271/18367	0.00132410076905241	0.0181446911302063	CCL3L3/CCL3/TNFSF13B/TNFSF10/CCL4/TGFB1/PYCARD/JAK2/VEGFA/ITGA5/TNF/CXCL16/IL1B/STAT1/SIVA1/IL1RN/CD300LF/CCR2/CXCL10/JAK1/SYK/IL27RA/ENG/CCRL2/TNFSF12/IL6R/SH2B3/CCDC88A/CX3CR1/CXCL8/USP15/STAT3/IL13RA1/IL6ST/GATA3/SDCBP/GRB2/MYD88/CASP8AP2/FERMT2/CSH1/FKBP1A/CD2AP/TRAP1/TGFBR3/DEFB1/TRIP6/IL18	48
GO:0016860	intramolecular oxidoreductase activity	14/2098	51/18367	0.00132726554208467	0.0181446911302063	P4HB/PDIA6/QSOX1/ECI1/TBXAS1/PDIA3/PDIA4/RPIA/EBP/ECI2/PTGES/PDIA5/ECH1/ENOPH1	14
GO:0016209	antioxidant activity	20/2098	86/18367	0.00139522372010013	0.0188439251835211	GPX1/SOD2/ALOX5AP/MGST3/PRDX2/GSTP1/PRDX4/GLRX/PRDX5/SOD1/S100A9/GPX8/TXN/PRDX3/PRDX6/PRDX1/MGST1/SOD3/PARK7/PTGES	20
GO:0019199	transmembrane receptor protein kinase activity	29/2098	143/18367	0.00145908212353164	0.0194512361817361	CSF1R/LYN/HCK/EFEMP1/EGFR/FGR/JAK2/BTK/MET/JAK1/NRP2/SYK/CSK/ENG/CRIM1/PTK2B/FLT1/WEE1/PBK/NRP1/LTBP1/BAZ1B/EPHB4/TTK/IGF1R/YES1/INSR/TGFBR3/PTK2	29
GO:0001848	complement binding	8/2098	21/18367	0.00147489302002459	0.0194512361817361	ITGB2/C5AR1/ITGAM/CD93/CALR/CD59/C1QBP/PHB	8
GO:0004714	transmembrane receptor protein tyrosine kinase activity	26/2098	124/18367	0.00152239406211901	0.019844229577156	CSF1R/LYN/HCK/EFEMP1/EGFR/FGR/JAK2/BTK/MET/JAK1/NRP2/SYK/CSK/CRIM1/PTK2B/FLT1/WEE1/PBK/NRP1/BAZ1B/EPHB4/TTK/IGF1R/YES1/INSR/PTK2	26
GO:0042974	retinoic acid receptor binding	9/2098	26/18367	0.00165392744715771	0.0213109502099286	NR4A2/FUS/HMGA1/VDR/NCOR2/ASXL1/ACTN4/ARID5A/PPARG	9
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	7/2098	17/18367	0.00172736191984019	0.0215152523571205	PYCARD/CASP1/CTSH/NLRP12/NLRP1/CASP8AP2/BAD	7
GO:0032393	MHC class I receptor activity	7/2098	17/18367	0.00172736191984019	0.0215152523571205	LILRB2/LILRB1/LILRB3/LILRA2/CTSH/LILRA6/LILRA5	7
GO:0046965	retinoid X receptor binding	7/2098	17/18367	0.00172736191984019	0.0215152523571205	NR4A2/FUS/HMGA1/VDR/NCOR2/ARID5A/PPARG	7
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	6/2098	13/18367	0.00185443214023635	0.0225958524913582	DUSP1/DUSP9/DUSP2/DUSP14/DUSP18/DUSP5	6
GO:0031994	insulin-like growth factor I binding	6/2098	13/18367	0.00185443214023635	0.0225958524913582	ITGA6/LRP2/ITGB4/ITGAV/IGF1R/INSR	6
GO:0016651	oxidoreductase activity, acting on NAD(P)H	20/2098	88/18367	0.00187656071749171	0.022619618971056	CYBB/NCF2/CYBA/NCF1/NDUFA10/NDUFB9/DCXR/NDUFB4/NDUFB7/NDUFA6/CYB5R4/NDUFV1/NDUFS8/NDUFV2/CYB5R1/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	20
GO:0004602	glutathione peroxidase activity	8/2098	22/18367	0.00208779531801396	0.0245855596370713	GPX1/ALOX5AP/MGST3/GSTP1/GPX8/PRDX6/MGST1/PTGES	8
GO:0070182	DNA polymerase binding	8/2098	22/18367	0.00208779531801396	0.0245855596370713	HMGB1/PCNA/HSP90AA1/HSP90AB1/RAD51/CDT1/FANCI/FANCD2	8
GO:0098631	cell adhesion mediator activity	15/2098	59/18367	0.00210545381370102	0.0245855596370713	DSP/RPSA/PDLIM1/KRT18/BSG/ITGB1/S100A11/BCAM/DSG2/CNN3/DSC2/TRIM29/SIRPA/JAM3/PALLD	15
GO:0015035	protein-disulfide reductase activity	11/2098	37/18367	0.00213235962658253	0.0246430426948352	P4HB/PDIA6/GLRX/QSOX1/SCO2/PDIA3/PDIA4/STAB1/GLRX5/TXN/PDIA5	11
GO:0048027	mRNA 5'-UTR binding	9/2098	27/18367	0.00223232407224473	0.0255350539284321	MYH10/RPS7/RPS14/RPL5/RARA/IGF2BP3/GNL3/NCL/SHMT1	9
GO:0008301	DNA binding, bending	7/2098	18/18367	0.00255017059348107	0.0285874123529228	HMGB1/HMGB2/TOP2A/HHEX/TFAM/HMGB3/FOXC1	7
GO:0030228	lipoprotein particle receptor activity	7/2098	18/18367	0.00255017059348107	0.0285874123529228	SORL1/LRP2/CXCL16/CD36/OLR1/APOBR/STAB1	7
GO:0019865	immunoglobulin binding	8/2098	23/18367	0.00288430659550638	0.0314302213579626	FCER1G/FCGR3A/FCGRT/FCGR2A/FCGR1A/FCGR1B/LILRA2/LGALS3	8
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	14/2098	55/18367	0.00288903725077097	0.0314302213579626	GPX1/ALOX5AP/MGST3/PRDX2/GSTP1/PRDX4/PRDX5/GPX8/PRDX3/PRDX6/PRDX1/MGST1/PARK7/PTGES	14
GO:0001968	fibronectin binding	9/2098	28/18367	0.0029606347419509	0.0314302213579626	CTSS/FBLN1/VEGFA/CTSL/ITGA4/ITGB1/PLEKHA2/CCDC80/ITGAV	9
GO:0051861	glycolipid binding	9/2098	28/18367	0.0029606347419509	0.0314302213579626	LYN/PSAP/CLEC4E/TREM2/PPT1/TPP1/GPAA1/MANF/SELL	9
GO:0034511	U3 snoRNA binding	5/2098	10/18367	0.00297199238532028	0.0314302213579626	ISG20/PRKDC/SNU13/XRCC5/BMS1	5
GO:0071723	lipopeptide binding	5/2098	10/18367	0.00297199238532028	0.0314302213579626	CD14/TLR2/TLR1/TLR6/CD1D	5
GO:0051287	NAD binding	14/2098	56/18367	0.00345473370925559	0.0361939858698646	ALDH2/PARP1/IDH2/HPGD/ALDH1A1/LDHA/UXS1/HADH/GRHPR/NDUFV1/MDH1/IDH1/QDPR/GAPDH	14
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	9/2098	29/18367	0.00386412281304613	0.0397327155504395	PLEK/NCF1/MYO1G/ADAP2/PLEKHA2/DAPP1/PHLDA3/COMMD1/PLEKHA1	9
GO:0051059	NF-kappaB binding	9/2098	29/18367	0.00386412281304613	0.0397327155504395	MTDH/NFKBIA/NPM1/NOTCH2/HDAC2/CDKN2A/COMMD7/APEX1/COMMD6	9
GO:0070003	threonine-type peptidase activity	8/2098	24/18367	0.00389883917087274	0.0397327155504395	PSMB9/PSMB8/PSMB2/PSMB5/PSMB6/PSMB1/PSMB10/PSMB7	8
GO:0004601	peroxidase activity	13/2098	51/18367	0.00397146961226262	0.0401082651833008	GPX1/ALOX5AP/MGST3/PRDX2/GSTP1/PRDX4/PRDX5/GPX8/PRDX3/PRDX6/PRDX1/MGST1/PTGES	13
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	14/2098	57/18367	0.00410760745547558	0.040748919978656	NDUFA10/NDUFB9/DCXR/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/NDUFS6/NDUFC2/NDUFA13/NDUFB10/NDUFA8	14
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	14/2098	57/18367	0.00410760745547558	0.040748919978656	IFI30/P4HB/PDIA6/GLRX/QSOX1/SCO2/PDIA3/PDIA4/STAB1/GLRX5/TXN/PRDX3/PCYOX1/PDIA5	14
GO:0005518	collagen binding	16/2098	69/18367	0.00415160909772022	0.0408241561275821	CTSS/CD44/TGFBI/FN1/CTSB/COL14A1/CTSL/ADGRG1/ITGB1/PPIB/SERPINH1/PCOLCE2/C1QTNF1/P3H1/PDGFA/ADGRG6	16
GO:0005041	low-density lipoprotein particle receptor activity	6/2098	15/18367	0.00442078430977783	0.0427215449246634	SORL1/LRP2/CXCL16/CD36/OLR1/STAB1	6
GO:1904680	peptide transmembrane transporter activity	6/2098	15/18367	0.00442078430977783	0.0427215449246634	TAP2/TAP1/GJA1/SLC15A3/TAPBP/SLC13A3	6
GO:0042826	histone deacetylase binding	25/2098	127/18367	0.00449553403782945	0.0430725953539043	SPI1/MEF2C/KLF4/PARP1/GMNN/CEBPB/MEF2A/TOP2A/HSP90AA1/HSP90AB1/RARA/CCND1/RBBP4/HDAC2/HNRNPD/BEX4/NCOR2/PHB/YWHAE/HSPA1A/TOP2B/MAGEA10/GLI3/BHLHE41/PKN1	25
GO:0004857	enzyme inhibitor activity	16/2098	70/18367	0.00482337754818257	0.0458220867077344	TXNIP/LRRK2/OAZ1/RPS7/RPL5/RPL37/NOTCH1/PARP9/RPL23/ANXA5/APOC1/FBXO5/ANXA3/DTX3L/RPS20/GCHFR	16
GO:0042608	T cell receptor binding	5/2098	11/18367	0.00493906385758208	0.0465268116331892	HLA-A/HLA-DRA/HLA-DRB1/HLA-E/DOCK2	5
GO:0016505	peptidase activator activity involved in apoptotic process	7/2098	20/18367	0.00505987805395189	0.0472676941540005	PYCARD/CASP1/CTSH/NLRP12/NLRP1/CASP8AP2/BAD	7
GO:0035925	mRNA 3'-UTR AU-rich region binding	8/2098	25/18367	0.00516792643525088	0.0478780622637706	ZFP36/ZFP36L2/ZFP36L1/EXOSC8/HNRNPD/KHSRP/HNRNPA0/TIA1	8
GO:0019887	protein kinase regulator activity	36/2098	204/18367	0.00525492619870607	0.0482850185963074	GMFG/NCKAP1L/LILRB4/RAC2/HMGB1/CXCL10/SOCS3/CD24/HSP90AB1/CKS1B/PKIB/NPM1/CCND1/CCNE1/RPLP1/CDKN1C/DAZAP2/TRIB1/CCND3/CHP1/CKS2/CALM2/CIB1/CCNA2/CCNE2/TPX2/RGCC/CDK4/CDKN2A/DBF4/MOB1A/CCNI/CDKN1A/STK4/PRKAG2/NCAPG2	36
GO:0004386	helicase activity	29/2098	156/18367	0.00551238604092774	0.0500506747917552	MCM7/HELLS/MCM3/MCM5/MCM6/RAD51/RFC3/MCM4/RFC4/RFC2/MCM2/SMARCA1/BLM/DDX60L/DSCC1/CHD9/XRCC5/RAD50/SMARCA2/XRCC6/DDX1/DDX58/POLQ/ASCC3/TTF2/DDX18/HLTF/SMARCA5/DDX3Y	29
GO:0019207	kinase regulator activity	40/2098	233/18367	0.00553638151130923	0.0500506747917552	GMFG/NCKAP1L/LILRB4/RAC2/HMGB1/KLF4/GSTP1/CXCL10/SOCS3/CD24/HSP90AB1/CKS1B/PKIB/TREM2/NPM1/CCND1/CCNE1/RPLP1/PIK3R5/CDKN1C/DAZAP2/TRIB1/CCND3/CHP1/CKS2/CALM2/CIB1/CCNA2/CCNE2/TPX2/RGCC/CDK4/CDKN2A/DBF4/MOB1A/CCNI/CDKN1A/STK4/PRKAG2/NCAPG2	40
GO:0048029	monosaccharide binding	16/2098	71/18367	0.00558106835660848	0.0500510210220648	LGALS9/SLC2A3/FBP1/COLEC12/LMAN1/CLEC4A/BSG/ENG/HK3/HK2/ALDOA/RPIA/FUOM/UGP2/PLOD2/P3H1	16
GO:0017069	snRNA binding	13/2098	53/18367	0.00565233117806335	0.050287803576262	ISG20/LSM2/LSM4/LSM3/SNRPD3/SNRPA1/LSM7/SNU13/COIL/SNRNP70/PRPF8/LSM8/TOE1	13
GO:0004713	protein tyrosine kinase activity	26/2098	136/18367	0.00570498529042002	0.0502965989152111	CSF1R/LYN/HCK/EFEMP1/EGFR/FGR/JAK2/BTK/MET/JAK1/NRP2/SYK/CSK/CRIM1/PTK2B/FLT1/WEE1/PBK/NRP1/BAZ1B/EPHB4/TTK/IGF1R/YES1/INSR/PTK2	26
GO:0043394	proteoglycan binding	10/2098	36/18367	0.00574305500548351	0.0502965989152111	CTSS/PTPRC/FN1/CTSB/CTSL/GPNMB/HPSE/SDCBP/PTPRF/PTN	10
GO:0015036	disulfide oxidoreductase activity	11/2098	42/18367	0.00625447159301427	0.0543508733005348	P4HB/PDIA6/GLRX/QSOX1/SCO2/PDIA3/PDIA4/STAB1/GLRX5/TXN/PDIA5	11
GO:0017070	U6 snRNA binding	6/2098	16/18367	0.00639736334753143	0.0551649562506364	LSM2/LSM4/LSM3/LSM7/PRPF8/LSM8	6
GO:0046332	SMAD binding	17/2098	79/18367	0.0071037610100583	0.0607886724601172	FLNA/FOS/SKIL/PARP1/MEF2A/LDLRAD4/USP15/RGCC/FERMT2/JUN/IPO7/FKBP1A/TGFBR3/EID2/SMAD5/PURA/PPARG	17
GO:0005516	calmodulin binding	35/2098	201/18367	0.00723837802547975	0.0614713770194151	MARCKS/SLC8A1/MYO1F/MYO1G/EGFR/MBP/MYH10/CNN2/RGS1/CALD1/CAMK1D/CAMK1/ATP2B1/KCNQ1/IQGAP2/ASPM/CAMK2D/CNN3/SPHK1/SYT7/MAPKAPK3/MYO1C/KCNN4/SPTBN1/TJP1/RIT1/NRGN/RGS2/SLC9A1/CAMK2G/PHKB/MYO5A/EPB41/EEA1/MYO7A	35
GO:0043047	single-stranded telomeric DNA binding	5/2098	12/18367	0.00767771931385431	0.0642292787375424	HNRNPA1/RPA2/RAD50/RPA1/HNRNPA2B1	5
GO:0061578	Lys63-specific deubiquitinase activity	5/2098	12/18367	0.00767771931385431	0.0642292787375424	TNFAIP3/USP27X/PSMD14/DESI2/BRCC3	5
GO:0098632	cell-cell adhesion mediator activity	12/2098	49/18367	0.00779548092244439	0.064731363807853	DSP/PDLIM1/KRT18/BSG/S100A11/DSG2/CNN3/DSC2/TRIM29/SIRPA/JAM3/PALLD	12
GO:0030169	low-density lipoprotein particle binding	6/2098	17/18367	0.00894463685354483	0.0737274846531158	MSR1/SORL1/COLEC12/CD36/TREM2/STAB1	6
GO:0055106	ubiquitin-protein transferase regulator activity	7/2098	22/18367	0.00907583902226959	0.0737931046417436	RPS7/RPL5/RPL37/RPL23/TRIB1/FBXO5/RPS20	7
GO:0070851	growth factor receptor binding	26/2098	141/18367	0.00918532379118361	0.0737931046417436	PYCARD/LYN/EFEMP1/JAK2/VEGFA/ITGA5/IL1B/APP/IL1RN/CD300LF/IL27RA/IL6R/CCDC88A/HBEGF/IL6ST/GATA3/SNX4/SDCBP/GRB2/MYD88/PLSCR1/VAV3/CD2AP/YES1/PDGFA/TRIP6	26
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	12/2098	50/18367	0.00921590958951303	0.0737931046417436	CKS1B/CCND1/CCNE1/CDKN1C/CCND3/CKS2/CCNA2/CCNE2/CDK4/CDKN2A/CCNI/CDKN1A	12
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	12/2098	50/18367	0.00921590958951303	0.0737931046417436	PIK3AP1/TLR2/PCNA/TLR1/TLR4/TLR6/TLR7/UNG/TLR8/MYD88/APEX1/DNPH1	12
GO:0001530	lipopolysaccharide binding	9/2098	33/18367	0.00978554797525243	0.0777985764557303	CD14/LY96/TLR2/HMGB1/TLR4/HSPD1/PTAFR/TREM2/P2RX7	9
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	10/2098	39/18367	0.0104642478243471	0.0826086043034727	MYO1G/ADAP2/BTK/IQGAP2/DAPP1/PHLDA3/PARD3/FERMT2/NRGN/COMMD1	10
GO:0031072	heat shock protein binding	24/2098	129/18367	0.0107595062226872	0.0836021710113997	ITGB2/ZFP36/ITGAM/GBP1/RPS3/DNAJC9/HSP90AB1/TFAM/HSPA5/SPN/HSPA8/FKBP5/HSPA6/KPNB1/HDAC2/TOMM34/TPR/BAG2/HSPA14/HSPA1A/HSPA9/ST13/DNAJB14/DNAJB9	24
GO:0008514	organic anion transmembrane transporter activity	32/2098	185/18367	0.0108843591972125	0.0836021710113997	SLC2A3/SLC16A3/CD36/SLC2A1/SLC38A1/SLC26A2/MPC2/SLC25A5/SLC29A1/GJA1/SLC2A6/SLC35B4/SLC6A6/SLC22A11/SLC25A1/SLC1A5/SLC16A12/SFXN3/SLC25A4/SLC16A1/SLC19A1/SFXN1/SLC52A1/SLC13A3/BEST1/SLC38A9/SLC25A17/MPC1/SLC25A6/SLC38A6/SLC3A2/SLC1A3	32
GO:0003785	actin monomer binding	8/2098	28/18367	0.0108884183476042	0.0836021710113997	TMSB4X/CORO1A/TMSB10/TWF2/COBLL1/PFN1/LIMA1/COBL	8
GO:0003953	NAD+ nucleosidase activity	8/2098	28/18367	0.0108884183476042	0.0836021710113997	PIK3AP1/TLR2/TLR1/TLR4/TLR6/TLR7/TLR8/MYD88	8
GO:0140677	molecular function activator activity	27/2098	150/18367	0.0110478863934749	0.0842495282114654	GMFG/CCL3/NCF2/NCF1/PSAP/ALOX5AP/GNAS/BTK/DDOST/NCF4/APOC1/RFC1/CALM2/SUZ12/PDCD5/XRCC5/PSMC3IP/DBF4/DTX3L/DNAJC19/SAE1/PARK7/DNAJC1/MMP15/DPM2/ARL1/NCAPG2	27
GO:0017124	SH3 domain binding	24/2098	130/18367	0.0118068434232462	0.0878131371070291	CYBA/SH3BGRL/NCF1/LYN/WAS/WIPF1/GPX1/ABI3/LRP2/DOCK4/VASP/SH3BP2/PTPN6/ARHGAP27/GJA1/SIRPA/GRB2/PLSCR1/FUT8/WASF2/HCLS1/BCAR1/INPP5D/CD2AP	24
GO:0005200	structural constituent of cytoskeleton	20/2098	103/18367	0.0119592928269484	0.0878131371070291	VIM/HLA-DRB1/MSN/TUBA1A/ACTB/TUBA1B/TUBB/DSP/ARPC3/TUBB4B/TUBA1C/ACTR2/ANK3/SPTBN1/ARPC4/ACTR3/DMD/CD2AP/YEATS4/EPB41	20
GO:0031490	chromatin DNA binding	20/2098	103/18367	0.0119592928269484	0.0878131371070291	ACTB/RARA/NOTCH1/BCL6/HMGN2/EZH2/HMGN3/RBBP4/SUZ12/STAT3/HDAC2/SMARCC1/POLE3/HMGN1/APEX1/KDM6B/ACTL6A/MBD2/MBD3/ACTN4	20
GO:0016922	nuclear receptor binding	26/2098	144/18367	0.011997898664687	0.0878131371070291	PCNA/OASL/NR4A2/PARP1/STAT1/CEBPB/FUS/CALR/NR4A1/PRKCB/PHB2/HMGN3/ISL1/STAT3/HMGA1/VDR/TRIM24/NCOR2/TACC2/PARK7/TRIP6/PKN1/ASXL1/ACTN4/ARID5A/PPARG	26
GO:0016853	isomerase activity	28/2098	158/18367	0.0120288719495045	0.0878131371070291	ISYNA1/HSPD1/P4HB/PDIA6/QSOX1/TOP2A/ECI1/TBXAS1/PPIA/PDIA3/PPIB/PPIC/PDIA4/DEGS1/FKBP5/FKBP3/RPIA/FUOM/DSE/EBP/ECI2/TOP2B/FKBP1A/PTGES/PDIA5/ECH1/ENOSF1/ENOPH1	28
GO:0000295	adenine nucleotide transmembrane transporter activity	6/2098	18/18367	0.0121418699835767	0.0878131371070291	SLC25A5/SLC29A1/SLC25A4/SLC19A1/SLC25A17/SLC25A6	6
GO:0005346	purine ribonucleotide transmembrane transporter activity	6/2098	18/18367	0.0121418699835767	0.0878131371070291	SLC25A5/SLC29A1/SLC25A4/SLC19A1/SLC25A17/SLC25A6	6
GO:0033549	MAP kinase phosphatase activity	6/2098	18/18367	0.0121418699835767	0.0878131371070291	DUSP1/DUSP9/DUSP2/DUSP14/DUSP18/DUSP5	6
GO:0005539	glycosaminoglycan binding	38/2098	230/18367	0.0123945340090774	0.0885411273733545	PTPRC/VCAN/CD44/TLR2/FN1/VEGFA/FBN1/APP/ADGRG1/ADGRE2/CXCL10/GPNMB/LRPAP1/NRP2/NLRP3/APLP2/BMP7/PPIA/ENG/TREM2/EXTL2/FSTL1/STAB1/HBEGF/ADAMTS1/PCOLCE2/C1QBP/CCDC80/SULF2/NRP1/HMMR/PDCD5/PTPRF/SOD3/SELL/MDK/TGFBR3/PTN	38
GO:0061135	endopeptidase regulator activity	33/2098	194/18367	0.0125160887858213	0.0885411273733545	TIMP1/SERPINA1/BST2/CST3/ITIH5/SPINT1/SPINT2/PEBP1/SERPINF1/APP/C3/PRDX5/CARD16/APLP2/TIMP2/TIMP3/CRIM1/CST6/PSME2/SERPINH1/NAIP/CSTB/BIRC5/BIRC3/NLRP1/RPS6KA1/PRDX3/PSMD14/CSTA/USP14/SERPINB8/SERPING1/GAPDH	33
GO:0031492	nucleosomal DNA binding	10/2098	40/18367	0.0125584649887274	0.0885411273733545	ACTB/HMGN2/HMGN3/RBBP4/HDAC2/SMARCC1/HMGN1/ACTL6A/MBD2/MBD3	10
GO:0042169	SH2 domain binding	10/2098	40/18367	0.0125584649887274	0.0885411273733545	LAT2/LILRB1/JAK2/PAG1/SYK/DAG1/PTPN6/SIGLEC10/CCDC88A/PTK2	10
GO:0004896	cytokine receptor activity	19/2098	97/18367	0.0128423236491016	0.0899765300665183	CD74/CXCR4/CD44/IL10RA/CD4/CCR1/CCR2/IL2RG/IFNGR2/IL27RA/CCRL2/IL6R/CX3CR1/IL13RA1/CSF2RB/IL6ST/IL17RA/CSF2RA/IFNGR1	19
GO:0051787	misfolded protein binding	8/2098	29/18367	0.0135643404560073	0.0944448798210196	HSPA5/HSPA8/HSPA6/SDF2L1/HSPA14/HSPA1A/HSPA9/DNAJB9	8
GO:0035259	glucocorticoid receptor binding	5/2098	14/18367	0.0159749102855237	0.110477545619926	NR4A2/CEBPB/NR4A1/STAT3/NCOR2	5
GO:0035615	clathrin adaptor activity	6/2098	19/18367	0.0160640855807742	0.110477545619926	AP1S2/AP1S3/AP1S1/AP2M1/AP2A2/LDLRAP1	6
GO:0005525	GTP binding	57/2098	377/18367	0.016539208247095	0.113051539298741	IFI44L/MX1/SAMHD1/GIMAP4/GBP4/GBP2/RAB32/RAC2/GBP5/TUBA1A/GIMAP7/LRRK2/MX2/TUBA1B/GIMAP1/TUBB/GBP1/GNAS/TGM2/RAN/HSP90AB1/CIITA/GIMAP2/TUBB4B/GNA15/RRAS/TUBA1C/RHOBTB3/GNAI2/HRAS/RHOA/RHEB/ARL2/RALB/RAB3D/RAP1A/RAB25/RIT1/RANBP17/GNA11/GNL3/EIF5B/GNAI1/RHOG/RHOQ/OLA1/GCH1/EIF5/GPN3/RHOB/INSR/NME1/DRG1/ARL1/RTKN/BMS1/RAC3	57
GO:0015026	coreceptor activity	11/2098	48/18367	0.017464057712562	0.118649749671406	CXCR4/CD86/LY96/CD4/ITGA4/ITGB1/ENG/NRP1/ITGAV/LRP5/TGFBR3	11
GO:0051087	chaperone binding	20/2098	107/18367	0.0178544826154975	0.120571536216703	HLA-B/FN1/LRP2/HSPD1/GRN/DNAJC9/SOD1/CALR/HSPE1/HSPA5/ERP29/BIRC5/HSPA8/BAG2/SDF2L1/TBCA/DNAJC1/SLC25A17/ST13/DNAJB9	20
GO:0005507	copper ion binding	13/2098	61/18367	0.0186706287191537	0.125327992779469	F5/S100A12/SCO2/SOD1/HAMP/CUTA/SOD3/PARK7/COMMD1/GPC1/SCO1/S100A13/COX17	13
GO:0051019	mitogen-activated protein kinase binding	7/2098	25/18367	0.0188676489368939	0.125896633680108	DUSP1/PTAFR/ARRB2/MAPKAPK3/TPR/GCH1/MAPK14	7
GO:0051536	iron-sulfur cluster binding	14/2098	68/18367	0.020034212157287	0.127317112356283	DPYD/RPS3/RSAD2/CISD1/GLRX5/NDUFV1/NDUFS8/POLA1/NDUFV2/NUBP2/ISCA1/UQCRFS1/KIF4A/PPAT	14
GO:0051540	metal cluster binding	14/2098	68/18367	0.020034212157287	0.127317112356283	DPYD/RPS3/RSAD2/CISD1/GLRX5/NDUFV1/NDUFS8/POLA1/NDUFV2/NUBP2/ISCA1/UQCRFS1/KIF4A/PPAT	14
GO:0004523	RNA-DNA hybrid ribonuclease activity	4/2098	10/18367	0.0202162765382859	0.127317112356283	FEN1/RNASEH2A/APEX1/EXO1	4
GO:0008330	protein tyrosine/threonine phosphatase activity	4/2098	10/18367	0.0202162765382859	0.127317112356283	DUSP1/DUSP9/DUSP2/DUSP5	4
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/2098	10/18367	0.0202162765382859	0.127317112356283	CYBB/NCF2/CYBA/NCF1	4
GO:0031419	cobalamin binding	4/2098	10/18367	0.0202162765382859	0.127317112356283	TCN2/MMAB/MTR/CD320	4
GO:0032356	oxidized DNA binding	4/2098	10/18367	0.0202162765382859	0.127317112356283	RPS3/MSH2/MSH6/BLM	4
GO:0034713	type I transforming growth factor beta receptor binding	4/2098	10/18367	0.0202162765382859	0.127317112356283	TGFB1/ENG/FERMT2/FKBP1A	4
GO:0047844	deoxycytidine deaminase activity	4/2098	10/18367	0.0202162765382859	0.127317112356283	APOBEC3A/CDA/APOBEC3G/APOBEC3C	4
GO:0098505	G-rich strand telomeric DNA binding	4/2098	10/18367	0.0202162765382859	0.127317112356283	HNRNPA1/RPA2/RPA1/HNRNPA2B1	4
GO:0003756	protein disulfide isomerase activity	6/2098	20/18367	0.020780174520841	0.127992173834411	P4HB/PDIA6/QSOX1/PDIA3/PDIA4/PDIA5	6
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	6/2098	20/18367	0.020780174520841	0.127992173834411	P4HB/PDIA6/QSOX1/PDIA3/PDIA4/PDIA5	6
GO:0031683	G-protein beta/gamma-subunit complex binding	6/2098	20/18367	0.020780174520841	0.127992173834411	GNAS/GNA15/PIK3R5/GNAI2/GNA11/GNAI1	6
GO:0140312	cargo adaptor activity	6/2098	20/18367	0.020780174520841	0.127992173834411	AP1S2/AP1S3/AP1S1/AP2M1/AP2A2/LDLRAP1	6
GO:0030414	peptidase inhibitor activity	31/2098	187/18367	0.0212423314371741	0.129701925741902	TIMP1/SERPINA1/BST2/CST3/ITIH5/SPINT1/SPINT2/PEBP1/SERPINF1/APP/C3/PRDX5/CARD16/APLP2/TIMP2/TIMP3/CRIM1/CST6/SERPINH1/NAIP/CSTB/BIRC5/BIRC3/RPS6KA1/PRDX3/CSTA/USP14/SERPINB8/SERPING1/GAPDH/GPC3	31
GO:0004866	endopeptidase inhibitor activity	30/2098	180/18367	0.0216334809967365	0.129701925741902	TIMP1/SERPINA1/BST2/CST3/ITIH5/SPINT1/SPINT2/PEBP1/SERPINF1/APP/C3/PRDX5/CARD16/APLP2/TIMP2/TIMP3/CRIM1/CST6/SERPINH1/NAIP/CSTB/BIRC5/BIRC3/RPS6KA1/PRDX3/CSTA/USP14/SERPINB8/SERPING1/GAPDH	30
GO:0005545	1-phosphatidylinositol binding	5/2098	15/18367	0.0217519732733966	0.129701925741902	SNX10/SCIN/PICALM/EPB41/EEA1	5
GO:0043138	3'-5' DNA helicase activity	5/2098	15/18367	0.0217519732733966	0.129701925741902	MCM5/MCM6/MCM2/BLM/ASCC3	5
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	5/2098	15/18367	0.0217519732733966	0.129701925741902	CYBB/NCF2/CYBA/NCF1/CYB5R4	5
GO:0098847	sequence-specific single stranded DNA binding	5/2098	15/18367	0.0217519732733966	0.129701925741902	HNRNPA1/RPA2/RAD50/RPA1/HNRNPA2B1	5
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	16/2098	82/18367	0.0219719608482836	0.130320466195375	CAPG/MYO1G/ADAP2/KCNQ1/SNX20/PHLDA3/SYT7/PARD3/TWF2/SDCBP/SCIN/PFN1/SLC9A1/COMMD1/PICALM/LDLRAP1	16
GO:0003713	transcription coactivator activity	41/2098	262/18367	0.0227427729389187	0.13418236033962	MTDH/PAGE4/TRIM22/HMGB1/LMO2/HMGB2/MAGED1/PDLIM1/FUS/NUCKS1/CIITA/NOTCH1/NPM1/VGLL1/BRCA1/PRKCB/RBPMS/HMGA1/BRD7/SMARCC1/BRD4/TRIM24/YAP1/SMARCA2/PSMC3IP/TRIM38/PMF1/ARID5B/USP22/APEX1/PARK7/RERE/MYCBP/CENPJ/TRIM28/ACTL6A/DRAP1/PKN1/ASXL1/ACTN4/DCAF6	41
GO:0016829	lyase activity	32/2098	196/18367	0.0238110691972685	0.139749783089727	HMGB1/ALOX5AP/GGCT/MGST3/HACD3/SDS/RPS3/ECI1/TBXAS1/RNASET2/RSAD2/ECHS1/PAICS/GLDC/SDSL/ECHDC2/ALDOA/UXS1/UMPS/APMAP/TSEN34/FH/XRCC5/XRCC6/PARK7/SHMT1/PISD/POLQ/HACD4/ENOSF1/ALAD/GLO1	32
GO:0140030	modification-dependent protein binding	27/2098	160/18367	0.0244165201312629	0.142556870141384	LAPTM5/LYN/TNFAIP3/MORC4/HSPD1/AGL/PTPN6/VAV1/CBX5/MSH6/USP15/SUZ12/BRD7/NCAPD3/CBX4/BRD4/TRIM24/KMT2E/RAD23B/ING2/UHRF1/VCP/YEATS4/PRPF8/PWP1/BRCC3/NCAPG2	27
GO:0004520	endodeoxyribonuclease activity	9/2098	38/18367	0.0245979195070664	0.14287185371721	RPS3/FEN1/RAD51C/RAD50/DNASE1L1/APEX1/ERCC1/RBBP8/EXO1	9
GO:0004536	deoxyribonuclease activity	12/2098	57/18367	0.0254792458239205	0.147228013240283	ISG20/RPS3/FEN1/RAD51C/RAD50/DNASE1L1/APEX1/MGME1/ERCC1/RBBP8/NME1/EXO1	12
GO:0015216	purine nucleotide transmembrane transporter activity	6/2098	21/18367	0.0263512961008112	0.150713280250047	SLC25A5/SLC29A1/SLC25A4/SLC19A1/SLC25A17/SLC25A6	6
GO:0140416	transcription regulator inhibitor activity	6/2098	21/18367	0.0263512961008112	0.150713280250047	ID1/ID3/ID4/ID2/PURA/NCAPG2	6
GO:0003743	translation initiation factor activity	11/2098	51/18367	0.0268296582595595	0.152340807281157	EIF1/EIF1AY/EIF5B/EIF5/EIF3J/AGO2/DENR/EIF3A/EIF1AX/EIF4G1/EIF3L	11
GO:0031406	carboxylic acid binding	29/2098	176/18367	0.0271212770110296	0.152340807281157	S100A8/FCN1/PSAP/ALOX5AP/TYMS/GSTP1/GLUL/RARA/S100A9/SIGLEC10/NR2F2/DHFR/SIGLEC9/CD33/ADH5/GLDC/SIGLEC7/APOC1/FABP5/VDR/NDUFAB1/GRHPR/FOLR1/SLC19A1/PLOD2/SHMT1/P3H1/PPARG/SLC1A3	29
GO:0045182	translation regulator activity	24/2098	140/18367	0.0274071726092601	0.152340807281157	TYMS/EIF1/PABPC1/RPS14/RARA/DHFR/IGF2BP3/ABCF1/RPS9/EIF1AY/TSFM/EIF5B/EIF2AK4/EIF2AK1/EIF5/EIF3J/AGO2/DENR/SHMT1/EIF3A/EIF1AX/PURA/EIF4G1/EIF3L	24
GO:0015215	nucleotide transmembrane transporter activity	7/2098	27/18367	0.0284901886295281	0.152340807281157	SLC25A5/SLC29A1/SLC25A36/SLC25A4/SLC19A1/SLC25A17/SLC25A6	7
GO:0043425	bHLH transcription factor binding	7/2098	27/18367	0.0284901886295281	0.152340807281157	LMO2/ISL1/BHLHE40/KLF5/FHL2/BHLHE41/NCAPG2	7
GO:0000900	translation repressor activity, mRNA regulatory element binding	5/2098	16/18367	0.0287313414215171	0.152340807281157	TYMS/RARA/DHFR/SHMT1/PURA	5
GO:0005092	GDP-dissociation inhibitor activity	5/2098	16/18367	0.0287313414215171	0.152340807281157	ARHGDIB/RANBP1/CCDC88A/EIF5/GPSM2	5
GO:1990404	protein ADP-ribosylase activity	5/2098	16/18367	0.0287313414215171	0.152340807281157	PARP1/PARP9/PARP2/PARP14/PARP12	5
GO:0005504	fatty acid binding	9/2098	39/18367	0.0288380210118823	0.152340807281157	S100A8/ALOX5AP/GSTP1/S100A9/ADH5/APOC1/FABP5/NDUFAB1/PPARG	9
GO:0005049	nuclear export signal receptor activity	4/2098	11/18367	0.0289461123558309	0.152340807281157	RAN/NUP214/CSE1L/RANBP17	4
GO:0005347	ATP transmembrane transporter activity	4/2098	11/18367	0.0289461123558309	0.152340807281157	SLC25A5/SLC25A4/SLC25A17/SLC25A6	4
GO:0005536	glucose binding	4/2098	11/18367	0.0289461123558309	0.152340807281157	SLC2A3/HK3/HK2/UGP2	4
GO:0008199	ferric iron binding	4/2098	11/18367	0.0289461123558309	0.152340807281157	FTH1/FTL/RRM2/ACP5	4
GO:0043560	insulin receptor substrate binding	4/2098	11/18367	0.0289461123558309	0.152340807281157	JAK2/GRB2/IGF1R/INSR	4
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	4/2098	11/18367	0.0289461123558309	0.152340807281157	DSP/DSG2/DSC2/SIRPA	4
GO:0097493	structural molecule activity conferring elasticity	4/2098	11/18367	0.0289461123558309	0.152340807281157	FBN2/FBN1/EMILIN2/LAMC1	4
GO:1990226	histone methyltransferase binding	4/2098	11/18367	0.0289461123558309	0.152340807281157	HSP90AB1/NOP56/CBX3/CBX1	4
GO:0005154	epidermal growth factor receptor binding	8/2098	33/18367	0.0291230363497864	0.152555718449115	EFEMP1/CCDC88A/HBEGF/SNX4/GRB2/PLSCR1/VAV3/YES1	8
GO:0019001	guanyl nucleotide binding	58/2098	398/18367	0.0306254563143802	0.158940446890834	IFI44L/MX1/SAMHD1/GIMAP4/GBP4/GBP2/RAB32/RAC2/GBP5/TUBA1A/GIMAP7/LRRK2/MX2/TUBA1B/GIMAP1/TUBB/GBP1/GNAS/TGM2/RAN/HSP90AB1/CIITA/GIMAP2/TUBB4B/GNA15/RRAS/TUBA1C/RHOBTB3/GNAI2/HRAS/RHOA/RHEB/ARL2/SLC19A1/RALB/RAB3D/RAP1A/RAB25/RIT1/RANBP17/GNA11/GNL3/EIF5B/GNAI1/RHOG/RHOQ/OLA1/GCH1/EIF5/GPN3/RHOB/INSR/NME1/DRG1/ARL1/RTKN/BMS1/RAC3	58
GO:0032561	guanyl ribonucleotide binding	58/2098	398/18367	0.0306254563143802	0.158940446890834	IFI44L/MX1/SAMHD1/GIMAP4/GBP4/GBP2/RAB32/RAC2/GBP5/TUBA1A/GIMAP7/LRRK2/MX2/TUBA1B/GIMAP1/TUBB/GBP1/GNAS/TGM2/RAN/HSP90AB1/CIITA/GIMAP2/TUBB4B/GNA15/RRAS/TUBA1C/RHOBTB3/GNAI2/HRAS/RHOA/RHEB/ARL2/SLC19A1/RALB/RAB3D/RAP1A/RAB25/RIT1/RANBP17/GNA11/GNL3/EIF5B/GNAI1/RHOG/RHOQ/OLA1/GCH1/EIF5/GPN3/RHOB/INSR/NME1/DRG1/ARL1/RTKN/BMS1/RAC3	58
GO:0015631	tubulin binding	55/2098	375/18367	0.031007315624405	0.160180648916857	S100A8/MX1/LYN/STMN1/LRRK2/MX2/RPS3/DAG1/PRC1/CENPF/S100A9/SMC3/NUSAP1/BRCA1/BIRC5/CCDC88A/GJA1/CNN3/CLIP1/ALDOA/CHP1/GPAA1/CCDC88B/KIF23/TPX2/ATF5/KIF21A/CACYBP/PDCD5/GTSE1/BEX4/BRCA2/KIF20B/TPR/KIF22/SKA2/HAUS8/EML4/RGS2/TBCA/SBDS/HOOK2/ARHGEF2/EZR/CENPJ/NME1/LRPPRC/GABARAP/KIF4A/DRG1/CCDC69/NDRG1/KIF11/GAPDH/KIFC1	55
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	6/2098	22/18367	0.0328295925052642	0.168816390818354	PRDX5/NAIP/BIRC5/BIRC3/RPS6KA1/PRDX3	6
GO:0030695	GTPase regulator activity	69/2098	488/18367	0.0357127462226243	0.181972675070736	ARHGDIB/NCKAP1L/GPSM3/WAS/ARHGAP30/LRRK2/DOCK10/HACD3/RGS18/FGD2/TAGAP/RANBP1/ADAP2/DOCK4/CYTH4/DOCK2/RGS1/RGS10/PREX1/RCBTB2/ARHGAP4/VAV1/DENND3/SPATA13/ARHGAP25/GMIP/IQGAP2/RASA1/ARHGAP27/CCDC88A/ALDH1A1/ITSN2/NRP1/ADRB1/RASGRP2/SMAP2/ABR/LAMTOR4/CYTH1/RIN3/DOCK9/ARHGAP26/SIRPA/FGD3/RAB3IP/DEPDC1/RAP1A/NET1/ARHGEF40/RGS2/JUN/SYDE2/ECT2/ARHGEF2/ARHGAP21/VAV3/ARHGAP10/ARHGAP23/FGD4/EPS8L2/IPO5/EIF5/IPO7/DOCK11/FAM13A/GPSM2/RTKN/ARFGEF3/RALGPS2	69
GO:0060589	nucleoside-triphosphatase regulator activity	69/2098	488/18367	0.0357127462226243	0.181972675070736	ARHGDIB/NCKAP1L/GPSM3/WAS/ARHGAP30/LRRK2/DOCK10/HACD3/RGS18/FGD2/TAGAP/RANBP1/ADAP2/DOCK4/CYTH4/DOCK2/RGS1/RGS10/PREX1/RCBTB2/ARHGAP4/VAV1/DENND3/SPATA13/ARHGAP25/GMIP/IQGAP2/RASA1/ARHGAP27/CCDC88A/ALDH1A1/ITSN2/NRP1/ADRB1/RASGRP2/SMAP2/ABR/LAMTOR4/CYTH1/RIN3/DOCK9/ARHGAP26/SIRPA/FGD3/RAB3IP/DEPDC1/RAP1A/NET1/ARHGEF40/RGS2/JUN/SYDE2/ECT2/ARHGEF2/ARHGAP21/VAV3/ARHGAP10/ARHGAP23/FGD4/EPS8L2/IPO5/EIF5/IPO7/DOCK11/FAM13A/GPSM2/RTKN/ARFGEF3/RALGPS2	69
GO:0090079	translation regulator activity, nucleic acid binding	19/2098	108/18367	0.0364313676661472	0.184794403410638	TYMS/EIF1/PABPC1/RARA/DHFR/ABCF1/EIF1AY/TSFM/EIF5B/EIF5/EIF3J/AGO2/DENR/SHMT1/EIF3A/EIF1AX/PURA/EIF4G1/EIF3L	19
GO:0005044	scavenger receptor activity	10/2098	47/18367	0.03690356561885	0.185873872909467	MSR1/COLEC12/CXCL16/CD36/MARCO/CD163/STAB1/SCARA3/LGALS3BP/PRSS12	10
GO:0070628	proteasome binding	5/2098	17/18367	0.0369758016581722	0.185873872909467	ID1/PSMG1/PSMD14/USP14/RAD23B	5
GO:0015459	potassium channel regulator activity	11/2098	54/18367	0.0393626765204854	0.192910983699628	FLNA/SGK1/KCNAB2/RASA1/KCNMB1/KCNE3/CHP1/YWHAE/DLG1/ENSA/AKAP9	11
GO:0004126	cytidine deaminase activity	4/2098	12/18367	0.0395803088768193	0.192910983699628	APOBEC3A/CDA/APOBEC3G/APOBEC3C	4
GO:0004875	complement receptor activity	4/2098	12/18367	0.0395803088768193	0.192910983699628	FPR1/C5AR1/FPR3/C3AR1	4
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	4/2098	12/18367	0.0395803088768193	0.192910983699628	CDK1/CDK4/BRD4/CDK6	4
GO:0017154	semaphorin receptor activity	4/2098	12/18367	0.0395803088768193	0.192910983699628	PLXNC1/MET/NRP2/NRP1	4
GO:0043422	protein kinase B binding	4/2098	12/18367	0.0395803088768193	0.192910983699628	ARRB2/RARA/CCDC88A/BAD	4
GO:0097677	STAT family protein binding	4/2098	12/18367	0.0395803088768193	0.192910983699628	SPI1/PARP9/DTX3L/PPARG	4
GO:0017134	fibroblast growth factor binding	6/2098	23/18367	0.0402572247568945	0.193776268237685	RPS19/RPS2/ITGAV/GPC1/TGFBR3/S100A13	6
GO:0070412	R-SMAD binding	6/2098	23/18367	0.0402572247568945	0.193776268237685	FOS/PARP1/LDLRAD4/RGCC/JUN/PPARG	6
GO:0042887	amide transmembrane transporter activity	8/2098	35/18367	0.0402764232822308	0.193776268237685	TAP2/AQP9/TAP1/GJA1/SLC15A3/TAPBP/SLC19A1/SLC13A3	8
GO:0005520	insulin-like growth factor binding	7/2098	29/18367	0.0409734333237665	0.196287259640779	ITGA6/LRP2/ITGB4/CRIM1/ITGAV/IGF1R/INSR	7
GO:0019205	nucleobase-containing compound kinase activity	9/2098	42/18367	0.0445609593250041	0.212565257035445	DTYMK/TK1/N4BP2/PNKP/NME4/ADK/DLG1/MPP1/NME1	9
GO:0003924	GTPase activity	49/2098	337/18367	0.0453106393179792	0.215225536760401	ARHGDIB/MX1/GBP4/GBP2/RAB32/RGS19/RAC2/GBP5/TUBA1A/GIMAP7/LRRK2/MX2/TUBA1B/TUBB/RGS18/GBP1/GNAS/RGS1/RGS10/RAN/TUBB4B/GNA15/RRAS/TUBA1C/RASA1/RHOBTB3/GNAI2/HRAS/RHOA/RHEB/ARL2/RALB/RAB3D/RAP1A/RAB25/RIT1/GNA11/EIF5B/GNAI1/RHOG/RGS2/RHOQ/GCH1/GPN3/RHOB/DRG1/ARL1/BMS1/RAC3	49
GO:1990841	promoter-specific chromatin binding	12/2098	62/18367	0.0458990356892059	0.217100502141771	KLF4/STAT1/DNMT1/EZH2/ISL1/HDAC2/USP3/FOXO4/RBL1/ERCC1/FOXC1/TRIM28	12
GO:0098641	cadherin binding involved in cell-cell adhesion	5/2098	18/18367	0.0465273138407089	0.219147558048045	PDLIM1/KRT18/S100A11/CNN3/TRIM29	5
GO:0001965	G-protein alpha-subunit binding	6/2098	24/18367	0.0486657241303814	0.22730948645899	RGS19/RGS1/RGS10/CCDC88A/RGS2/GPSM2	6
GO:0019957	C-C chemokine binding	6/2098	24/18367	0.0486657241303814	0.22730948645899	CXCR4/ZFP36/CCR1/CCR2/CCRL2/CX3CR1	6
GO:0004869	cysteine-type endopeptidase inhibitor activity	11/2098	56/18367	0.0496839575825949	0.231102557884186	CST3/PRDX5/CARD16/CST6/NAIP/CSTB/BIRC5/BIRC3/RPS6KA1/PRDX3/CSTA	11
GO:0004860	protein kinase inhibitor activity	13/2098	70/18367	0.0518393858167371	0.238574687326304	GMFG/LILRB4/SOCS3/PKIB/NPM1/CDKN1C/TRIB1/CHP1/CIB1/CDKN2A/CDKN1A/PRKAG2/NCAPG2	13
GO:0005542	folic acid binding	4/2098	13/18367	0.0521416578010209	0.238574687326304	TYMS/DHFR/FOLR1/SLC19A1	4
GO:0016840	carbon-nitrogen lyase activity	4/2098	13/18367	0.0521416578010209	0.238574687326304	GGCT/SDS/SDSL/APMAP	4
GO:0031386	protein tag	4/2098	13/18367	0.0521416578010209	0.238574687326304	ISG15/UBB/RPS27A/NEDD8	4
GO:0002020	protease binding	22/2098	135/18367	0.0545158599466343	0.247418133603956	TIMP1/SERPINA1/PYCARD/CST3/FN1/PSAP/MBP/TNF/TNFAIP3/CARD16/ADAMTSL4/TIMP2/ITGB1/DPP4/TIMP3/CSTB/ITGAV/CSTA/BRCA2/PARK7/SELL/VCP	22
GO:0043177	organic acid binding	22/2098	135/18367	0.0545158599466343	0.247418133603956	S100A8/ALOX5AP/TYMS/GLUL/RARA/S100A9/NR2F2/DHFR/DDAH2/GLDC/FABP5/VDR/FOLR1/SLC19A1/ASS1/ID3/PLOD2/SHMT1/P3H1/GCHFR/PPARG/SLC1A3	22
GO:0000146	microfilament motor activity	7/2098	31/18367	0.0565490584486814	0.252555755063633	MYO1F/MYO1G/MYH10/MYL6/MYO1C/MYO5A/MYO7A	7
GO:0005164	tumor necrosis factor receptor binding	7/2098	31/18367	0.0565490584486814	0.252555755063633	TNFSF13B/TNFSF10/TNF/STAT1/SIVA1/TNFSF12/TRAP1	7
GO:0071813	lipoprotein particle binding	7/2098	31/18367	0.0565490584486814	0.252555755063633	MSR1/SORL1/COLEC12/HSPD1/CD36/TREM2/STAB1	7
GO:0071814	protein-lipid complex binding	7/2098	31/18367	0.0565490584486814	0.252555755063633	MSR1/SORL1/COLEC12/HSPD1/CD36/TREM2/STAB1	7
GO:1901981	phosphatidylinositol phosphate binding	27/2098	173/18367	0.0573521080184481	0.254307794408798	CAPG/MYO1G/PHLDA2/FGD2/ADAP2/BTK/KCNQ1/NCF4/IQGAP2/SNX20/DAPP1/PHLDA3/SYT7/PARD3/TWF2/SDCBP/SCIN/FERMT2/NRGN/PFN1/SLC9A1/COMMD1/PLEKHA5/PICALM/WIPI2/SNX24/LDLRAP1	27
GO:0003887	DNA-directed DNA polymerase activity	6/2098	25/18367	0.0580756426125354	0.254307794408798	POLD3/POLE3/POLA1/POLD4/POLQ/POLE2	6
GO:0005160	transforming growth factor beta receptor binding	6/2098	25/18367	0.0580756426125354	0.254307794408798	TGFB1/ENG/USP15/FERMT2/FKBP1A/TGFBR3	6
GO:0008327	methyl-CpG binding	6/2098	25/18367	0.0580756426125354	0.254307794408798	DNMT1/CXXC5/ERH/UHRF1/MBD2/MBD3	6
GO:0035035	histone acetyltransferase binding	6/2098	25/18367	0.0580756426125354	0.254307794408798	PCNA/STAT1/CEBPB/MEF2A/EID1/GLI3	6
GO:0015399	primary active transmembrane transporter activity	28/2098	181/18367	0.0589267658677638	0.257030756956277	TAP2/TAP1/SLC26A2/COX6A1/CYB5A/ATP6V1F/ATP2B1/NDUFA10/NDUFB9/ATP6V1C2/TAPBP/NDUFB4/NDUFB7/NDUFA6/NDUFV1/NDUFS8/NDUFV2/CYC1/UQCR10/NDUFS6/ATP6V1B2/COX5A/UQCRFS1/NDUFC2/NDUFA13/ATP6V0E1/NDUFB10/NDUFA8	28
GO:1902936	phosphatidylinositol bisphosphate binding	18/2098	107/18367	0.0594198223780251	0.258176825138628	CAPG/MYO1G/ADAP2/KCNQ1/SNX20/PHLDA3/SYT7/PARD3/TWF2/SDCBP/SCIN/PFN1/SLC9A1/COMMD1/PLEKHA5/PICALM/WIPI2/LDLRAP1	18
GO:0051018	protein kinase A binding	10/2098	51/18367	0.0601947334714101	0.260533962244983	LRRK2/RPS3/RARA/CSK/KCNQ1/RDX/WASF2/EZR/AKAP1/AKAP9	10
GO:0015175	neutral amino acid transmembrane transporter activity	8/2098	38/18367	0.0617830010772906	0.266379785414011	SLC38A1/SLC6A6/SLC1A5/SFXN3/SFXN1/SLC38A9/SLC38A6/SLC3A2	8
GO:0016835	carbon-oxygen lyase activity	14/2098	79/18367	0.0625411055220682	0.268311580346279	HACD3/RPS3/ECI1/TBXAS1/ECHS1/ECHDC2/FH/XRCC5/XRCC6/PARK7/POLQ/HACD4/ENOSF1/ALAD	14
GO:0042379	chemokine receptor binding	13/2098	72/18367	0.0627097538365076	0.268311580346279	CCL3L3/CCL3/CCL4/CXCL16/STAT1/CCR2/CXCL10/JAK1/CCRL2/CX3CR1/CXCL8/STAT3/DEFB1	13
GO:0015605	organophosphate ester transmembrane transporter activity	7/2098	32/18367	0.0655409499078555	0.276548029558865	SLC25A5/SLC29A1/SLC25A36/SLC25A4/SLC19A1/SLC25A17/SLC25A6	7
GO:0050699	WW domain binding	7/2098	32/18367	0.0655409499078555	0.276548029558865	LITAF/TCEAL4/DAZAP2/KIF20B/PRRG4/TCEAL8/WBP11	7
GO:0140658	ATP-dependent chromatin remodeler activity	7/2098	32/18367	0.0655409499078555	0.276548029558865	HELLS/SMARCA1/CHD9/SMARCA2/TTF2/HLTF/SMARCA5	7
GO:0005172	vascular endothelial growth factor receptor binding	4/2098	14/18367	0.0666083568072198	0.276548029558865	VEGFA/ITGA5/CCDC88A/CD2AP	4
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4/2098	14/18367	0.0666083568072198	0.276548029558865	ECI1/EBP/ECI2/ECH1	4
GO:0019992	diacylglycerol binding	4/2098	14/18367	0.0666083568072198	0.276548029558865	CHPT1/RASGRP2/DGKD/CDIPT	4
GO:0036041	long-chain fatty acid binding	4/2098	14/18367	0.0666083568072198	0.276548029558865	S100A8/ALOX5AP/S100A9/PPARG	4
GO:0044548	S100 protein binding	4/2098	14/18367	0.0666083568072198	0.276548029558865	S100A6/S100A11/CACYBP/EZR	4
GO:0003727	single-stranded RNA binding	15/2098	87/18367	0.067421489123456	0.278891104455329	HMGB1/TLR7/PABPC1/L1TD1/HNRNPA1/HNRNPDL/TLR8/MSI2/RBPMS/CBX4/DDX1/DDX58/AGO2/TIA1/LACTB2	15
GO:0033293	monocarboxylic acid binding	13/2098	73/18367	0.0686739611444409	0.283027611922493	S100A8/PSAP/ALOX5AP/GSTP1/RARA/S100A9/NR2F2/ADH5/APOC1/FABP5/VDR/NDUFAB1/PPARG	13
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	8/2098	39/18367	0.0702849314167508	0.288605890542775	POLR2L/POLR2H/POLR3K/POLR2F/POLR2I/PRIM1/POLR2K/POLR2J3	8
GO:0005085	guanyl-nucleotide exchange factor activity	33/2098	223/18367	0.0720045153719156	0.294587816539844	DOCK10/FGD2/TAGAP/DOCK4/CYTH4/DOCK2/PREX1/RCBTB2/VAV1/DENND3/SPATA13/CCDC88A/ITSN2/ADRB1/RASGRP2/ABR/LAMTOR4/CYTH1/RIN3/DOCK9/FGD3/RAB3IP/RAP1A/NET1/ARHGEF40/ECT2/ARHGEF2/VAV3/FGD4/EPS8L2/DOCK11/ARFGEF3/RALGPS2	33
GO:0004864	protein phosphatase inhibitor activity	9/2098	46/18367	0.0731758107980761	0.298291214198703	PHACTR1/LGALS3/SET/PPP1R14B/PHACTR2/ENSA/PTN/PPP1R35/URI1	9
GO:0019210	kinase inhibitor activity	13/2098	74/18367	0.0749979821408107	0.304611369492206	GMFG/LILRB4/SOCS3/PKIB/NPM1/CDKN1C/TRIB1/CHP1/CIB1/CDKN2A/CDKN1A/PRKAG2/NCAPG2	13
GO:0008200	ion channel inhibitor activity	7/2098	33/18367	0.0753457727888739	0.304919174354974	RASA1/CAMK2D/CALM2/PHPT1/COMMD1/ENSA/PACSIN3	7
GO:0008238	exopeptidase activity	17/2098	103/18367	0.0757242959768609	0.305348689892306	GGH/QPCT/LAP3/CTSH/VASH1/CTSZ/MME/DPP4/CTSV/ENPEP/TPP1/SCPEP1/ANPEP/LTA4H/DPEP2/TFRC/MMP15	17
GO:0004177	aminopeptidase activity	8/2098	40/18367	0.079465078338868	0.318854075854321	LAP3/CTSH/DPP4/CTSV/ENPEP/ANPEP/LTA4H/MMP15	8
GO:0004683	calmodulin-dependent protein kinase activity	6/2098	27/18367	0.0799268468466228	0.318854075854321	CAMK1D/CAMK1/PTK2B/CAMK2D/MAPKAPK3/CAMK2G	6
GO:0051393	alpha-actinin binding	6/2098	27/18367	0.0799268468466228	0.318854075854321	PDLIM1/DAG1/RARA/PDLIM7/PALLD/PPARG	6
GO:0043021	ribonucleoprotein complex binding	23/2098	149/18367	0.0822356506940707	0.323878261499997	NEAT1/SNRPG/EIF1/RPSA/RPN2/SNRPD1/SNRPB/UNG/CCDC47/NPM1/CBX5/HSPA5/RPLP1/SERBP1/EZH2/C1QBP/SND1/SBDS/OLA1/MALSU1/NME1/SNRPD2/TMEM147	23
GO:0004029	aldehyde dehydrogenase (NAD+) activity	4/2098	15/18367	0.0829197690013373	0.323878261499997	ALDH2/ALDH7A1/ADH5/ALDH1A1	4
GO:0004953	icosanoid receptor activity	4/2098	15/18367	0.0829197690013373	0.323878261499997	PTGER4/CYSLTR1/HPGD/PPARG	4
GO:0005161	platelet-derived growth factor receptor binding	4/2098	15/18367	0.0829197690013373	0.323878261499997	LYN/VEGFA/ITGA5/PDGFA	4
GO:0032794	GTPase activating protein binding	4/2098	15/18367	0.0829197690013373	0.323878261499997	FMNL1/TUBB/CDH1/GNAI1	4
GO:0050998	nitric-oxide synthase binding	4/2098	15/18367	0.0829197690013373	0.323878261499997	CD74/ACTB/SLC6A4/DMD	4
GO:0016248	channel inhibitor activity	7/2098	34/18367	0.0859627025891251	0.334597880563921	RASA1/CAMK2D/CALM2/PHPT1/COMMD1/ENSA/PACSIN3	7
GO:0008201	heparin binding	25/2098	166/18367	0.0907571364831415	0.351526574090819	PTPRC/FN1/VEGFA/FBN1/APP/ADGRG1/CXCL10/GPNMB/LRPAP1/NRP2/APLP2/BMP7/FSTL1/HBEGF/ADAMTS1/PCOLCE2/CCDC80/NRP1/PDCD5/PTPRF/SOD3/SELL/MDK/TGFBR3/PTN	25
GO:0048020	CCR chemokine receptor binding	9/2098	48/18367	0.09093907804312	0.351526574090819	CCL3L3/CCL3/CCL4/STAT1/CCR2/JAK1/CCRL2/STAT3/DEFB1	9
GO:0000287	magnesium ion binding	32/2098	221/18367	0.0944760179433912	0.360171117119354	DUT/LRRK2/IRAK3/PGP/FEN1/GLUL/TOP2A/RAN/COMT/IDH2/WEE1/MSH2/NUDT8/MSH6/SPHK1/RPS6KA1/RHEB/MAP3K8/PLSCR1/PRIM1/SRPK1/GNAI1/IDH1/NUDT5/PPA1/DCTPP1/STK4/NME1/RPS6KA5/ENOSF1/FIGNL1/ENOPH1	32
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	3/2098	10/18367	0.0967096398331183	0.360171117119354	RAD50/ERCC1/RBBP8	3
GO:0001094	TFIID-class transcription factor complex binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	NOP58/ERCC1/FBL	3
GO:0004300	enoyl-CoA hydratase activity	3/2098	10/18367	0.0967096398331183	0.360171117119354	ECI1/ECHS1/ECHDC2	3
GO:0004955	prostaglandin receptor activity	3/2098	10/18367	0.0967096398331183	0.360171117119354	PTGER4/HPGD/PPARG	3
GO:0005522	profilin binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	WIPF1/VASP/RHOQ	3
GO:0005528	FK506 binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	FKBP5/FKBP3/FKBP1A	3
GO:0016176	superoxide-generating NADPH oxidase activator activity	3/2098	10/18367	0.0967096398331183	0.360171117119354	NCF2/NCF1/NCF4	3
GO:0035374	chondroitin sulfate binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	ADGRE2/MDK/PTN	3
GO:0035612	AP-2 adaptor complex binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	BMP2K/AAK1/LDLRAP1	3
GO:0043208	glycosphingolipid binding	3/2098	10/18367	0.0967096398331183	0.360171117119354	LYN/PSAP/SELL	3
GO:0005540	hyaluronic acid binding	5/2098	22/18367	0.0979322746152295	0.361125262643659	VCAN/CD44/STAB1/C1QBP/HMMR	5
GO:0030742	GTP-dependent protein binding	5/2098	22/18367	0.0979322746152295	0.361125262643659	RAB32/RAB3D/GCH1/GCHFR/EEA1	5
GO:0033691	sialic acid binding	5/2098	22/18367	0.0979322746152295	0.361125262643659	FCN1/SIGLEC10/SIGLEC9/CD33/SIGLEC7	5
GO:0019212	phosphatase inhibitor activity	9/2098	49/18367	0.100690869690065	0.362825224859482	PHACTR1/LGALS3/SET/PPP1R14B/PHACTR2/ENSA/PTN/PPP1R35/URI1	9
GO:0032813	tumor necrosis factor receptor superfamily binding	9/2098	49/18367	0.100690869690065	0.362825224859482	TNFSF13B/TNFSF10/TNF/STAT1/SIVA1/TNFSF12/MYD88/CASP8AP2/TRAP1	9
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	4/2098	16/18367	0.100982578194611	0.362825224859482	ALDH2/ALDH7A1/ADH5/ALDH1A1	4
GO:0008191	metalloendopeptidase inhibitor activity	4/2098	16/18367	0.100982578194611	0.362825224859482	TIMP1/BST2/TIMP2/TIMP3	4
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	4/2098	16/18367	0.100982578194611	0.362825224859482	FEN1/DNASE1L1/APEX1/EXO1	4
GO:0050135	NAD(P)+ nucleosidase activity	4/2098	16/18367	0.100982578194611	0.362825224859482	TLR2/TLR1/TLR4/TLR6	4
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	4/2098	16/18367	0.100982578194611	0.362825224859482	TLR2/TLR1/TLR4/TLR6	4
GO:0070492	oligosaccharide binding	4/2098	16/18367	0.100982578194611	0.362825224859482	LGALS1/LGALS9/CHID1/SELL	4
GO:0008013	beta-catenin binding	14/2098	85/18367	0.10142174543924	0.363238902994852	KLF4/CDH1/NR4A2/GJA1/KANK1/DLG5/FOXO4/VCL/TBL1X/CD2AP/GLI3/NUMB/KDM6B/PTPRU	14
GO:0046625	sphingolipid binding	6/2098	29/18367	0.105758717278322	0.37756535690764	LYN/PSAP/CD300LF/PHB2/VDAC1/SELL	6
GO:0035091	phosphatidylinositol binding	38/2098	271/18367	0.106144581691731	0.377739924052161	NCF1/CAPG/MYO1G/SNX10/PHLDA2/FGD2/ADAP2/BTK/KCNQ1/NCF4/IQGAP2/SNX20/CCDC88A/DAPP1/GPAA1/PHLDA3/SYT7/SH3YL1/PARD3/SNX4/TWF2/SDCBP/SCIN/FERMT2/NRGN/PFN1/SLC9A1/COMMD1/PLEKHA5/ING2/PICALM/PITPNB/EPB41/SNX7/WIPI2/SNX24/EEA1/LDLRAP1	38
GO:0042805	actinin binding	7/2098	36/18367	0.109596608945252	0.381644466698656	CSRP2/PDLIM1/DAG1/RARA/PDLIM7/PALLD/PPARG	7
GO:0061631	ubiquitin conjugating enzyme activity	7/2098	36/18367	0.109596608945252	0.381644466698656	UBE2L6/UBE2T/UBE2C/UBE2S/UBE2D1/AKTIP/UBE2N	7
GO:0099106	ion channel regulator activity	21/2098	139/18367	0.110618275681151	0.381644466698656	FXYD5/FLNA/FXYD3/SGK1/KCNAB2/TSPAN13/PRKCB/RASA1/CAMK2D/KCNMB1/KCNE3/CHP1/CALM2/YWHAE/PHPT1/COMMD1/DLG1/ENSA/PTPN3/AKAP9/PACSIN3	21
GO:0015932	nucleobase-containing compound transmembrane transporter activity	9/2098	50/18367	0.111016351896392	0.381644466698656	SLC25A5/HNRNPA3/SLC29A1/SLC35B4/SLC25A36/SLC25A4/SLC19A1/SLC25A17/SLC25A6	9
GO:0034062	5'-3' RNA polymerase activity	8/2098	43/18367	0.111053306306411	0.381644466698656	POLR2L/POLR2H/POLR3K/POLR2F/POLR2I/PRIM1/POLR2K/POLR2J3	8
GO:0097747	RNA polymerase activity	8/2098	43/18367	0.111053306306411	0.381644466698656	POLR2L/POLR2H/POLR3K/POLR2F/POLR2I/PRIM1/POLR2K/POLR2J3	8
GO:0005543	phospholipid binding	62/2098	466/18367	0.112688182056257	0.381644466698656	NCF1/CAPG/CD300A/MYO1G/PSAP/HMGB1/SNX10/PHLDA2/PEBP1/FGD2/PTAFR/ADAP2/CD300LF/BTK/PREX1/MME/TREM2/PLA2G7/KCNQ1/NCF4/IQGAP2/SNX20/PPT1/CCDC88A/TPP1/HSPA8/DAPP1/ANXA5/GPAA1/APOC1/PHLDA3/SYT7/SH3YL1/PARD3/ARHGAP26/SNX4/EPN2/TWF2/SDCBP/SCIN/SPTBN1/VDAC1/FERMT2/ANXA3/NRGN/STOML2/PFN1/NME4/SLC9A1/COMMD1/BAD/PLEKHA5/ING2/PICALM/PITPNB/PACSIN3/EPB41/SNX7/WIPI2/SNX24/EEA1/LDLRAP1	62
GO:0003950	NAD+ ADP-ribosyltransferase activity	5/2098	23/18367	0.1139531217981	0.381644466698656	PARP1/PARP9/PARP2/PARP14/PARP12	5
GO:0004529	exodeoxyribonuclease activity	5/2098	23/18367	0.1139531217981	0.381644466698656	ISG20/FEN1/APEX1/MGME1/EXO1	5
GO:0008143	poly(A) binding	5/2098	23/18367	0.1139531217981	0.381644466698656	PABPC1/HNRNPDL/RBPMS/DDX1/TIA1	5
GO:0016493	C-C chemokine receptor activity	5/2098	23/18367	0.1139531217981	0.381644466698656	CXCR4/CCR1/CCR2/CCRL2/CX3CR1	5
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	5/2098	23/18367	0.1139531217981	0.381644466698656	ISG20/FEN1/APEX1/MGME1/EXO1	5
GO:0050750	low-density lipoprotein particle receptor binding	5/2098	23/18367	0.1139531217981	0.381644466698656	HSP90B1/LRPAP1/PICALM/AP2M1/LDLRAP1	5
GO:1901681	sulfur compound binding	37/2098	265/18367	0.114590607580122	0.381644466698656	PTPRC/FN1/VEGFA/FBN1/GSTP1/APP/ADGRG1/ADGRE2/CXCL10/GPNMB/LRPAP1/NRP2/APLP2/BMP7/PPIA/DBI/FSTL1/ACBD6/ACADVL/HBEGF/ADAMTS1/SULT1A1/PCOLCE2/CCDC80/NRP1/CHST15/PDCD5/DHTKD1/PTPRF/MGST1/SOD3/ECI2/SELL/PTGES/MDK/TGFBR3/PTN	37
GO:0030276	clathrin binding	12/2098	72/18367	0.115018082071712	0.381644466698656	AP1S2/LRRK2/NSG1/SYT7/EPN2/AP1S3/CLTA/AP1S1/PICALM/AP2M1/AP2A2/LDLRAP1	12
GO:0046943	carboxylic acid transmembrane transporter activity	24/2098	163/18367	0.115832300558685	0.381644466698656	SLC7A7/SLC16A3/AQP9/CD36/SLC27A2/SLC38A1/SLC26A2/MPC2/SLC6A6/SLC25A1/SLC1A5/SLC16A12/SFXN3/SLC16A1/SLC19A1/SFXN1/SLC13A3/SLC7A6/SLC38A9/MPC1/SLC38A6/SLC3A2/SLC1A3/SLC10A3	24
GO:0008509	anion transmembrane transporter activity	43/2098	314/18367	0.119123268481816	0.381644466698656	SLC2A3/SLC16A3/CD36/SLC2A1/FXYD3/SLC38A1/SLC26A2/CLDN4/MPC2/SLC25A5/LRRC8C/SLC29A1/GJA1/SLC2A6/SLC35B4/SLC6A6/SLC22A11/SLC25A1/SLC6A4/SLC13A4/CLIC1/SLC1A5/SLC16A12/SFXN3/SLC25A4/SLC16A1/SLC19A1/SFXN1/VDAC1/TTYH3/SLC9A1/SLC52A1/SLC13A3/GABRE/BEST1/VDAC3/SLC38A9/SLC25A17/MPC1/SLC25A6/SLC38A6/SLC3A2/SLC1A3	43
GO:0047485	protein N-terminus binding	17/2098	110/18367	0.120598881257124	0.381644466698656	ALOX5AP/RPS21/PARP1/GLRX/ZWINT/NPM1/ID1/PHB2/RPA2/CALM2/SMARCC1/SDCBP/NCOR2/HSPA1A/VPS25/EPB41/MYO7A	17
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	4/2098	17/18367	0.120676970975053	0.381644466698656	PTPRC/PTPN6/PTPRF/PTPRU	4
GO:0005149	interleukin-1 receptor binding	4/2098	17/18367	0.120676970975053	0.381644466698656	IL1B/IL1RN/MYD88/TRIP6	4
GO:0005324	long-chain fatty acid transporter activity	4/2098	17/18367	0.120676970975053	0.381644466698656	CD36/SLC2A1/SLC27A2/FABP5	4
GO:0019198	transmembrane receptor protein phosphatase activity	4/2098	17/18367	0.120676970975053	0.381644466698656	PTPRC/PTPN6/PTPRF/PTPRU	4
GO:0042625	ATPase-coupled ion transmembrane transporter activity	4/2098	17/18367	0.120676970975053	0.381644466698656	ATP6V1F/ATP6V1C2/ATP6V1B2/ATP6V0E1	4
GO:0043024	ribosomal small subunit binding	4/2098	17/18367	0.120676970975053	0.381644466698656	EIF1/UNG/NPM1/NME1	4
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4/2098	17/18367	0.120676970975053	0.381644466698656	ATP6V1F/ATP6V1C2/ATP6V1B2/ATP6V0E1	4
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4/2098	17/18367	0.120676970975053	0.381644466698656	ATP6V1F/ATP6V1C2/ATP6V1B2/ATP6V0E1	4
GO:0070064	proline-rich region binding	4/2098	17/18367	0.120676970975053	0.381644466698656	CSK/CCND1/YAP1/PFN1	4
GO:0005342	organic acid transmembrane transporter activity	24/2098	164/18367	0.121735907475382	0.381644466698656	SLC7A7/SLC16A3/AQP9/CD36/SLC27A2/SLC38A1/SLC26A2/MPC2/SLC6A6/SLC25A1/SLC1A5/SLC16A12/SFXN3/SLC16A1/SLC19A1/SFXN1/SLC13A3/SLC7A6/SLC38A9/MPC1/SLC38A6/SLC3A2/SLC1A3/SLC10A3	24
GO:0000774	adenyl-nucleotide exchange factor activity	3/2098	11/18367	0.122120962637101	0.381644466698656	BAG2/PFN1/SIL1	3
GO:0002162	dystroglycan binding	3/2098	11/18367	0.122120962637101	0.381644466698656	DAG1/VCL/DMD	3
GO:0004954	prostanoid receptor activity	3/2098	11/18367	0.122120962637101	0.381644466698656	PTGER4/HPGD/PPARG	3
GO:0008603	cAMP-dependent protein kinase regulator activity	3/2098	11/18367	0.122120962637101	0.381644466698656	CXCL10/PKIB/PRKAG2	3
GO:0010485	H4 histone acetyltransferase activity	3/2098	11/18367	0.122120962637101	0.381644466698656	HAT1/BRCA2/USP22	3
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	3/2098	11/18367	0.122120962637101	0.381644466698656	P4HB/QSOX1/PCYOX1	3
GO:0019855	calcium channel inhibitor activity	3/2098	11/18367	0.122120962637101	0.381644466698656	CALM2/PHPT1/PACSIN3	3
GO:0022889	serine transmembrane transporter activity	3/2098	11/18367	0.122120962637101	0.381644466698656	SLC1A5/SFXN3/SFXN1	3
GO:0032404	mismatch repair complex binding	3/2098	11/18367	0.122120962637101	0.381644466698656	PCNA/MSH2/MSH6	3
GO:0035197	siRNA binding	3/2098	11/18367	0.122120962637101	0.381644466698656	TLR7/AGO2/MBD2	3
GO:0035673	oligopeptide transmembrane transporter activity	3/2098	11/18367	0.122120962637101	0.381644466698656	GJA1/SLC15A3/SLC13A3	3
GO:0047429	nucleoside-triphosphate diphosphatase activity	3/2098	11/18367	0.122120962637101	0.381644466698656	DUT/NUDT15/DCTPP1	3
GO:1901612	cardiolipin binding	3/2098	11/18367	0.122120962637101	0.381644466698656	MME/STOML2/NME4	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	7/2098	37/18367	0.122579753033682	0.381644466698656	ALDH2/ALDH7A1/ADH5/AKR1B1/ALDH1A1/PDHA1/GAPDH	7
GO:0042056	chemoattractant activity	7/2098	37/18367	0.122579753033682	0.381644466698656	CCL3/HMGB1/VEGFA/HMGB2/CXCL10/GPNMB/LGALS3	7
GO:0043531	ADP binding	7/2098	37/18367	0.122579753033682	0.381644466698656	MYH10/TAP1/MSH2/MSH6/VCP/PRKAG2/MYO7A	7
GO:0046915	transition metal ion transmembrane transporter activity	7/2098	37/18367	0.122579753033682	0.381644466698656	SLC11A1/SLC40A1/SLC25A37/SLC39A10/SLC39A1/TRPM2/SLC39A7	7
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	8/2098	44/18367	0.122902455377533	0.381644466698656	ALDH2/ALDH7A1/ADH5/AKR1B1/ALDH1A1/DHTKD1/PDHA1/GAPDH	8
GO:0140104	molecular carrier activity	12/2098	73/18367	0.124134958319699	0.384406873691666	RAN/SCO2/NUP214/HSPA8/KPNB1/CSE1L/NDUFAB1/RANBP17/PARK7/SCO1/IPO5/COX17	12
GO:0048306	calcium-dependent protein binding	14/2098	88/18367	0.125384363920481	0.387206258828815	S100A8/S100A4/S100A6/S100A12/S100A9/S100A11/S100A10/CHP1/CALM2/ANXA3/SLC9A1/S100A13/RAC3/SEC31A	14
GO:0005096	GTPase activator activity	61/2098	462/18367	0.127148644818762	0.391575908906133	ARHGDIB/NCKAP1L/ARHGAP30/LRRK2/DOCK10/HACD3/RGS18/FGD2/TAGAP/RANBP1/ADAP2/DOCK4/CYTH4/DOCK2/RGS1/RGS10/PREX1/RCBTB2/ARHGAP4/VAV1/DENND3/SPATA13/ARHGAP25/GMIP/IQGAP2/RASA1/ARHGAP27/CCDC88A/ALDH1A1/ITSN2/NRP1/ADRB1/RASGRP2/SMAP2/ABR/LAMTOR4/CYTH1/RIN3/DOCK9/ARHGAP26/FGD3/RAB3IP/DEPDC1/RAP1A/NET1/ARHGEF40/RGS2/JUN/SYDE2/ECT2/ARHGEF2/ARHGAP21/VAV3/ARHGAP10/ARHGAP23/FGD4/EPS8L2/DOCK11/FAM13A/ARFGEF3/RALGPS2	61
GO:0002039	p53 binding	11/2098	66/18367	0.127507260433053	0.391604490261513	HSPD1/PLK3/TRIM29/TRIAP1/BLM/USP10/BRD7/SMYD2/BRD4/TRIM24/KMT5A	11
GO:0004197	cysteine-type endopeptidase activity	18/2098	119/18367	0.130770486309405	0.398377322080346	CTSS/PYCARD/CTSB/CTSL/CASP1/CTSH/CTSD/CTSZ/PDIA3/CTSV/USP1/GPAA1/USP48/USP15/USP10/USP14/CAPNS1/CAPN1	18
GO:0050431	transforming growth factor beta binding	5/2098	24/18367	0.131134015921184	0.398377322080346	CD36/ENG/LTBP1/ITGAV/TGFBR3	5
GO:0051537	2 iron, 2 sulfur cluster binding	5/2098	24/18367	0.131134015921184	0.398377322080346	CISD1/GLRX5/NDUFV2/ISCA1/UQCRFS1	5
GO:0070840	dynein complex binding	5/2098	24/18367	0.131134015921184	0.398377322080346	CENPF/SMC3/TPR/ATMIN/GPSM2	5
GO:0008157	protein phosphatase 1 binding	6/2098	31/18367	0.135361353761978	0.406809859429429	PHACTR1/LILRB2/LILRB1/KCNQ1/STAU1/PPP1R15A	6
GO:0090482	vitamin transmembrane transporter activity	6/2098	31/18367	0.135361353761978	0.406809859429429	SLC2A3/SLC2A1/SLC2A6/SLC19A1/SLC52A1/SLC19A3	6
GO:0140142	nucleocytoplasmic carrier activity	6/2098	31/18367	0.135361353761978	0.406809859429429	RAN/NUP214/KPNB1/CSE1L/RANBP17/IPO5	6
GO:0140318	protein transporter activity	6/2098	31/18367	0.135361353761978	0.406809859429429	LRP2/RHBDF2/MCL1/TOMM40/SEC63/IGF1R	6
GO:0047834	D-threo-aldose 1-dehydrogenase activity	4/2098	18/18367	0.141862587299152	0.424074560966264	AKR7A2/KCNAB2/AKR1B1/GCLM	4
GO:0070122	isopeptidase activity	4/2098	18/18367	0.141862587299152	0.424074560966264	PSMD7/PSMD14/PRPF8/BRCC3	4
GO:0008017	microtubule binding	37/2098	271/18367	0.143531476716738	0.426819755624968	S100A8/MX1/LRRK2/MX2/RPS3/PRC1/CENPF/S100A9/NUSAP1/BIRC5/CCDC88A/CNN3/CLIP1/CHP1/CCDC88B/KIF23/TPX2/KIF21A/GTSE1/KIF20B/KIF22/SKA2/HAUS8/EML4/SBDS/HOOK2/ARHGEF2/EZR/LRPPRC/GABARAP/KIF4A/DRG1/CCDC69/NDRG1/KIF11/GAPDH/KIFC1	37
GO:0019003	GDP binding	12/2098	75/18367	0.143542415584846	0.426819755624968	GBP1/RAN/RRAS/HRAS/RHOA/RHEB/ARL2/RALB/RAP1A/RIT1/GNAI1/RHOB	12
GO:0060090	molecular adaptor activity	49/2098	369/18367	0.147183944965031	0.432066358687554	AP1S2/TRIM22/SCIMP/DOK2/KLF4/COL14A1/LRRK2/SYNE2/PAG1/ADAP2/STX11/CBX5/SH2B3/PSMG1/HSPA8/DDB1/ITSN2/CIB1/LAMTOR4/FRMD4A/STAT3/POLD3/DLG5/SDCBP/ANK3/GRB2/AP1S3/TCOF1/RAD50/ARPC4/ANKRD9/PDE4DIP/OBSL1/AP1S1/EPS8/SLC9A1/STX10/GNB4/DLG1/SGTB/AKAP9/AP2M1/ST13/EIF4G1/HOMER1/MPP7/AP2A2/LDLRAP1/STX6	49
GO:0030674	protein-macromolecule adaptor activity	40/2098	296/18367	0.147613533843223	0.432066358687554	AP1S2/TRIM22/DOK2/KLF4/COL14A1/LRRK2/SYNE2/PAG1/ADAP2/STX11/CBX5/SH2B3/HSPA8/DDB1/CIB1/FRMD4A/STAT3/POLD3/DLG5/SDCBP/ANK3/GRB2/AP1S3/TCOF1/RAD50/ARPC4/ANKRD9/OBSL1/AP1S1/EPS8/SLC9A1/STX10/GNB4/AP2M1/ST13/HOMER1/MPP7/AP2A2/LDLRAP1/STX6	40
GO:0004519	endonuclease activity	19/2098	129/18367	0.148090960988421	0.432066358687554	RNASE6/RPS3/FEN1/RNASET2/POP7/RAD51C/RNASEH2A/N4BP2/TSEN34/RAD50/PNKP/SND1/DNASE1L1/APEX1/ERCC1/AGO2/RBBP8/EXO1/LACTB2	19
GO:0061980	regulatory RNA binding	8/2098	46/18367	0.148482965612448	0.432066358687554	NEAT1/TLR7/HNRNPA1/SOX4/HNRNPA2B1/AGO2/MBD2/YBX1	8
GO:0030247	polysaccharide binding	5/2098	25/18367	0.149398609248347	0.432066358687554	HLA-DRA/HLA-DRB1/CLEC7A/GPCPD1/AGL	5
GO:0034237	protein kinase A regulatory subunit binding	5/2098	25/18367	0.149398609248347	0.432066358687554	KCNQ1/WASF2/EZR/AKAP1/AKAP9	5
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	3/2098	12/18367	0.149634513890528	0.432066358687554	CDKN1C/CDKN2A/CDKN1A	3
GO:0005024	transforming growth factor beta-activated receptor activity	3/2098	12/18367	0.149634513890528	0.432066358687554	ENG/LTBP1/TGFBR3	3
GO:0005095	GTPase inhibitor activity	3/2098	12/18367	0.149634513890528	0.432066358687554	IQGAP2/IPO5/RTKN	3
GO:0005527	macrolide binding	3/2098	12/18367	0.149634513890528	0.432066358687554	FKBP5/FKBP3/FKBP1A	3
GO:0008429	phosphatidylethanolamine binding	3/2098	12/18367	0.149634513890528	0.432066358687554	CD300A/PEBP1/TREM2	3
GO:0004674	protein serine/threonine kinase activity	51/2098	386/18367	0.150187265887339	0.432066358687554	CCL3/EGFR/LRRK2/IRAK3/SGK1/PRKDC/PLK3/SYK/CAMK1D/CAMK1/CDK1/ENG/PTK2B/VRK1/BMP2K/PRKCB/CAMK2D/PBK/CHEK1/NRK/AAK1/CCND3/LTBP1/MAP3K2/PKMYT1/RPS6KA1/MAPKAPK3/MAP3K8/CDK4/BRD4/STK17A/CDK6/SRPK1/EIF2AK4/TTK/CAMK2G/MASTL/STK17B/EIF2AK1/PAK6/CDK2/AURKB/TLK1/STK4/TGFBR3/PLK2/MAP3K4/RPS6KA5/PKN1/MAPK14/PRKAG2	51
GO:0061650	ubiquitin-like protein conjugating enzyme activity	7/2098	39/18367	0.150750609460062	0.432066358687554	UBE2L6/UBE2T/UBE2C/UBE2S/UBE2D1/AKTIP/UBE2N	7
GO:0016247	channel regulator activity	21/2098	145/18367	0.151110696420555	0.432066358687554	FXYD5/FLNA/FXYD3/SGK1/KCNAB2/TSPAN13/PRKCB/RASA1/CAMK2D/KCNMB1/KCNE3/CHP1/CALM2/YWHAE/PHPT1/COMMD1/DLG1/ENSA/PTPN3/AKAP9/PACSIN3	21
GO:0030332	cyclin binding	6/2098	32/18367	0.151473754651391	0.432066358687554	CDK1/CDK4/CDK6/XRCC6/CDKN1A/CDK2	6
GO:0071889	14-3-3 protein binding	6/2098	32/18367	0.151473754651391	0.432066358687554	HLA-F/ZFP36/ARRB2/ZFP36L1/DDIT4/BAD	6
GO:0015078	proton transmembrane transporter activity	19/2098	130/18367	0.15593336851485	0.443658137322709	SLC11A1/HVCN1/COX6A1/CYB5A/SLC25A5/ATP6V1F/SLC25A3/SLC15A3/ATP6V1C2/SLC25A4/SLC9A1/ATP6V1B1/CYC1/UQCR10/TCIRG1/ATP6V1B2/COX5A/UQCRFS1/ATP6V0E1	19
GO:0008135	translation factor activity, RNA binding	13/2098	84/18367	0.158264860670339	0.44819911079516	EIF1/ABCF1/EIF1AY/TSFM/EIF5B/EIF5/EIF3J/AGO2/DENR/EIF3A/EIF1AX/EIF4G1/EIF3L	13
GO:0019209	kinase activator activity	16/2098	107/18367	0.158329034678754	0.44819911079516	NCKAP1L/HMGB1/CD24/CKS1B/TREM2/RPLP1/DAZAP2/CKS2/CALM2/TPX2/RGCC/DBF4/MOB1A/CDKN1A/STK4/PRKAG2	16
GO:0022804	active transmembrane transporter activity	53/2098	406/18367	0.166523579024636	0.470208896943618	SLC11A1/SLC8A1/SLC16A3/TAP2/TAP1/SLC38A1/SLC26A2/COX6A1/CYB5A/SLC25A5/ATP6V1F/ATP2B1/SLC25A3/SLC15A3/NDUFA10/NDUFB9/SLC6A6/SLC22A11/ATP6V1C2/SLC25A1/TAPBP/SLC6A4/SLC13A4/NDUFB4/NDUFB7/SLC1A5/SLC16A12/NDUFA6/SLC25A4/SLC16A1/SLC19A1/SLC20A1/NDUFV1/NDUFS8/SLC9A1/NDUFV2/SLC13A3/CYC1/UQCR10/NDUFS6/ATP6V1B2/COX5A/SLC7A6/UQCRFS1/NDUFC2/NDUFA13/ATP6V0E1/SLC25A6/NDUFB10/SLC3A2/SLC1A3/NDUFA8/SLC10A3	53
GO:0003823	antigen binding	24/2098	171/18367	0.168058151154687	0.471493777933559	HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DRB1/FCN1/HLA-C/CD48/HLA-F/HLA-DQB1/HLA-DQA1/TGFB1/HLA-E/HLA-DRB5/TAP2/ITGA4/TAP1/LILRA2/CD1D/DHCR24/TAPBP/SIRPA/TSPAN4	24
GO:0001637	G protein-coupled chemoattractant receptor activity	5/2098	26/18367	0.168661021366064	0.471493777933559	CXCR4/CCR1/CCR2/CCRL2/CX3CR1	5
GO:0004950	chemokine receptor activity	5/2098	26/18367	0.168661021366064	0.471493777933559	CXCR4/CCR1/CCR2/CCRL2/CX3CR1	5
GO:0030371	translation repressor activity	5/2098	26/18367	0.168661021366064	0.471493777933559	TYMS/RARA/DHFR/SHMT1/PURA	5
GO:0072341	modified amino acid binding	14/2098	93/18367	0.171821603099256	0.479134370831506	CD300A/HMGB1/TYMS/CD300LF/MME/TREM2/DHFR/HSPA8/SYT7/FOLR1/SLC19A1/SCIN/MGST1/PTGES	14
GO:0016779	nucleotidyltransferase activity	19/2098	132/18367	0.172282316907516	0.479226990703041	OAS2/POLR2L/OAS1/POLR2H/POLR3K/POLD3/POLR2F/POLR2I/PRIM1/POLE3/NUDT5/POLR2K/POLA1/POLD4/UGP2/CDS1/POLQ/POLR2J3/POLE2	19
GO:0030295	protein kinase activator activity	15/2098	101/18367	0.174487566961514	0.484159808326379	NCKAP1L/HMGB1/CD24/CKS1B/RPLP1/DAZAP2/CKS2/CALM2/TPX2/RGCC/DBF4/MOB1A/CDKN1A/STK4/PRKAG2	15
GO:0004859	phospholipase inhibitor activity	3/2098	13/18367	0.178882370717381	0.48436506660431	ANXA5/APOC1/ANXA3	3
GO:0008035	high-density lipoprotein particle binding	3/2098	13/18367	0.178882370717381	0.48436506660431	HSPD1/CD36/TREM2	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/2098	13/18367	0.178882370717381	0.48436506660431	GLRX/TXN/PRDX3	3
GO:0019104	DNA N-glycosylase activity	3/2098	13/18367	0.178882370717381	0.48436506660431	PCNA/UNG/APEX1	3
GO:0034236	protein kinase A catalytic subunit binding	3/2098	13/18367	0.178882370717381	0.48436506660431	CSK/KCNQ1/EZR	3
GO:0034450	ubiquitin-ubiquitin ligase activity	3/2098	13/18367	0.178882370717381	0.48436506660431	ANAPC11/PRPF19/UBE4B	3
GO:0042301	phosphate ion binding	3/2098	13/18367	0.178882370717381	0.48436506660431	GNG12/PNP/CHST14	3
GO:0060590	ATPase regulator activity	3/2098	13/18367	0.178882370717381	0.48436506660431	BAG2/PFN1/SIL1	3
GO:0061133	endopeptidase activator activity	3/2098	13/18367	0.178882370717381	0.48436506660431	PSME2/NLRP1/PSMD14	3
GO:0072542	protein phosphatase activator activity	3/2098	13/18367	0.178882370717381	0.48436506660431	CALM2/PPP1R15A/B3GAT3	3
GO:0016859	cis-trans isomerase activity	7/2098	41/18367	0.181631710650764	0.489445066441121	PPIA/PPIB/PPIC/DEGS1/FKBP5/FKBP3/FKBP1A	7
GO:0048487	beta-tubulin binding	7/2098	41/18367	0.181631710650764	0.489445066441121	SMC3/PDCD5/EML4/RGS2/TBCA/LRPPRC/GABARAP	7
GO:0004725	protein tyrosine phosphatase activity	15/2098	102/18367	0.184347379616036	0.491127732241228	PTPRC/DUSP1/DUSP9/PGP/DUSP2/PTPN6/PTPN14/DUSP14/DUSP18/PTPRF/DUSP5/PTP4A2/PTPN3/UBASH3B/PTPRU	15
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	6/2098	34/18367	0.186054308532397	0.491127732241228	FEN1/POP7/RNASEH2A/APEX1/AGO2/EXO1	6
GO:0030291	protein serine/threonine kinase inhibitor activity	6/2098	34/18367	0.186054308532397	0.491127732241228	PKIB/CDKN1C/CIB1/CDKN2A/CDKN1A/PRKAG2	6
GO:0035198	miRNA binding	6/2098	34/18367	0.186054308532397	0.491127732241228	NEAT1/HNRNPA1/SOX4/HNRNPA2B1/AGO2/YBX1	6
GO:0043548	phosphatidylinositol 3-kinase binding	6/2098	34/18367	0.186054308532397	0.491127732241228	CORO1A/HCST/PIK3AP1/JAK2/IGF1R/INSR	6
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	4/2098	20/18367	0.188076085620889	0.491127732241228	FOS/STAT1/CEBPB/EZH2	4
GO:0001091	RNA polymerase II general transcription initiation factor binding	4/2098	20/18367	0.188076085620889	0.491127732241228	NOP58/ERCC1/DRAP1/FBL	4
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	4/2098	20/18367	0.188076085620889	0.491127732241228	ATP6V1F/ATP6V1C2/ATP6V1B2/ATP6V0E1	4
GO:0016500	protein-hormone receptor activity	4/2098	20/18367	0.188076085620889	0.491127732241228	LGR5/LGR4/IGF1R/INSR	4
GO:0030506	ankyrin binding	4/2098	20/18367	0.188076085620889	0.491127732241228	PTPRC/SLC8A1/CDH1/SPTBN1	4
GO:0031690	adrenergic receptor binding	4/2098	20/18367	0.188076085620889	0.491127732241228	GNAS/ARRB2/C1QBP/ADRB1	4
GO:0004709	MAP kinase kinase kinase activity	5/2098	27/18367	0.188827879211391	0.491127732241228	EGFR/LRRK2/MAP3K2/MAP3K8/MAP3K4	5
GO:0022884	macromolecule transmembrane transporter activity	5/2098	27/18367	0.188827879211391	0.491127732241228	HNRNPA3/SLC15A3/MCL1/TOMM40/SEC63	5
GO:0030507	spectrin binding	5/2098	27/18367	0.188827879211391	0.491127732241228	PTPRC/GBP1/ANK3/EPB41/MYO7A	5
GO:0070006	metalloaminopeptidase activity	5/2098	27/18367	0.188827879211391	0.491127732241228	LAP3/ENPEP/ANPEP/LTA4H/MMP15	5
GO:0008234	cysteine-type peptidase activity	26/2098	190/18367	0.189940140785083	0.492734392392778	CTSS/PYCARD/CTSB/CTSL/GGH/CASP1/TNFAIP3/CTSH/CTSD/CTSZ/PDIA3/CTSV/USP1/GPAA1/USP48/USP15/USP10/USP27X/PSMD14/USP14/USP3/CAPNS1/USP22/DESI2/CAPN1/BRCC3	26
GO:0016836	hydro-lyase activity	10/2098	64/18367	0.190324702860011	0.492734392392778	HACD3/ECI1/TBXAS1/ECHS1/ECHDC2/FH/PARK7/HACD4/ENOSF1/ALAD	10
GO:0016887	ATP hydrolysis activity	36/2098	272/18367	0.195494072050079	0.504951278267599	MCM7/HSPD1/MCM3/MCM5/MCM6/HSP90AA1/ATAD2/ATP2B1/HSPA5/MCM4/RHOBTB3/HSPA8/MCM2/RNF213/HSPA6/NLRP1/KIF23/BLM/DDX60L/KIF21A/CHD9/KIF20B/KIF22/HSPA14/OLA1/DDX1/HSPA1A/DDX58/ASCC3/VCP/DDX18/HSPA9/SMARCA5/FIGNL1/DDX3Y/KIFC1	36
GO:0001046	core promoter sequence-specific DNA binding	7/2098	42/18367	0.197986865111623	0.50904421052782	FOS/STAT1/CEBPB/NPM1/EZH2/AGO2/DRAP1	7
GO:0051539	4 iron, 4 sulfur cluster binding	7/2098	42/18367	0.197986865111623	0.50904421052782	DPYD/RSAD2/NDUFV1/NDUFS8/POLA1/NUBP2/PPAT	7
GO:0035064	methylated histone binding	11/2098	73/18367	0.207500045623586	0.526518161761116	MORC4/CBX5/MSH6/SUZ12/NCAPD3/CBX4/KMT2E/ING2/UHRF1/PWP1/NCAPG2	11
GO:0140034	methylation-dependent protein binding	11/2098	73/18367	0.207500045623586	0.526518161761116	MORC4/CBX5/MSH6/SUZ12/NCAPD3/CBX4/KMT2E/ING2/UHRF1/PWP1/NCAPG2	11
GO:0015926	glucosidase activity	3/2098	14/18367	0.209502556329243	0.526518161761116	AGL/GANAB/GAA	3
GO:0017110	nucleoside-diphosphatase activity	3/2098	14/18367	0.209502556329243	0.526518161761116	ENTPD1/NUDT15/NUDT5	3
GO:0030983	mismatched DNA binding	3/2098	14/18367	0.209502556329243	0.526518161761116	PCNA/MSH2/MSH6	3
GO:0043023	ribosomal large subunit binding	3/2098	14/18367	0.209502556329243	0.526518161761116	NPM1/OLA1/MALSU1	3
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	3/2098	14/18367	0.209502556329243	0.526518161761116	PTAFR/P2RY13/P2RY11	3
GO:0015101	organic cation transmembrane transporter activity	5/2098	28/18367	0.209800273512638	0.526518161761116	SLC29A1/SLC44A1/SLC25A17/SLC44A2/SLC19A3	5
GO:0050681	androgen receptor binding	5/2098	28/18367	0.209800273512638	0.526518161761116	CALR/PRKCB/PARK7/PKN1/ARID5A	5
GO:0070325	lipoprotein particle receptor binding	5/2098	28/18367	0.209800273512638	0.526518161761116	HSP90B1/LRPAP1/PICALM/AP2M1/LDLRAP1	5
GO:0008028	monocarboxylic acid transmembrane transporter activity	9/2098	58/18367	0.212603247888301	0.526518161761116	SLC16A3/CD36/SLC27A2/MPC2/SLC6A6/SLC16A12/SLC16A1/MPC1/SLC10A3	9
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	9/2098	58/18367	0.212603247888301	0.526518161761116	ALOX5AP/GSTP1/FDPS/SMS/FDFT1/MGST1/SRM/PTGES/MMAB	9
GO:0051117	ATPase binding	13/2098	89/18367	0.212712033196983	0.526518161761116	EGFR/SNX10/RDX/NOP58/RALB/SNU13/SVIP/SDF2L1/EZR/TCIRG1/PTPN3/FBL/UBE4B	13
GO:0001614	purinergic nucleotide receptor activity	4/2098	21/18367	0.212767820943609	0.526518161761116	PTAFR/P2RY13/P2RX7/P2RY11	4
GO:0016502	nucleotide receptor activity	4/2098	21/18367	0.212767820943609	0.526518161761116	PTAFR/P2RY13/P2RX7/P2RY11	4
GO:0070577	lysine-acetylated histone binding	4/2098	21/18367	0.212767820943609	0.526518161761116	BRD7/BRD4/TRIM24/YEATS4	4
GO:0140033	acetylation-dependent protein binding	4/2098	21/18367	0.212767820943609	0.526518161761116	BRD7/BRD4/TRIM24/YEATS4	4
GO:0005246	calcium channel regulator activity	7/2098	43/18367	0.214890612657081	0.529433795139753	SGK1/TSPAN13/PRKCB/CALM2/YWHAE/PHPT1/PACSIN3	7
GO:0032266	phosphatidylinositol-3-phosphate binding	7/2098	43/18367	0.214890612657081	0.529433795139753	NCF4/SNX20/PHLDA3/PARD3/PLEKHA5/WIPI2/SNX24	7
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	6/2098	36/18367	0.223360478106348	0.547892988965461	APOBEC3A/CDA/APOBEC3G/APOBEC3C/GCH1/AMPD3	6
GO:0034061	DNA polymerase activity	6/2098	36/18367	0.223360478106348	0.547892988965461	POLD3/POLE3/POLA1/POLD4/POLQ/POLE2	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5/2098	29/18367	0.23147559772812	0.561653993621694	CDK1/CCND3/CDK4/CDK6/CDK2	5
GO:0015301	anion:anion antiporter activity	5/2098	29/18367	0.23147559772812	0.561653993621694	SLC26A2/SLC25A5/SLC25A4/SLC19A1/SLC25A6	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	5/2098	29/18367	0.23147559772812	0.561653993621694	DPYD/TECR/TBXAS1/DHCR24/AKR1B1	5
GO:0070717	poly-purine tract binding	5/2098	29/18367	0.23147559772812	0.561653993621694	PABPC1/HNRNPDL/RBPMS/DDX1/TIA1	5
GO:0097472	cyclin-dependent protein kinase activity	5/2098	29/18367	0.23147559772812	0.561653993621694	CDK1/CCND3/CDK4/CDK6/CDK2	5
GO:0004712	protein serine/threonine/tyrosine kinase activity	7/2098	44/18367	0.232293777547806	0.562421867453759	SGK1/PBK/RPS6KA1/MAPKAPK3/TTK/AURKB/MAPK14	7
GO:0000062	fatty-acyl-CoA binding	4/2098	22/18367	0.238286831238804	0.570310531210394	DBI/ACBD6/ACADVL/ECI2	4
GO:0072349	modified amino acid transmembrane transporter activity	4/2098	22/18367	0.238286831238804	0.570310531210394	GJA1/SLC16A12/SLC19A1/SLC13A3	4
GO:0004879	nuclear receptor activity	8/2098	52/18367	0.2383445730511	0.570310531210394	NR4A2/NR2F6/RARA/NR2F2/NR4A1/STAT3/VDR/PPARG	8
GO:0098531	ligand-activated transcription factor activity	8/2098	52/18367	0.2383445730511	0.570310531210394	NR4A2/NR2F6/RARA/NR2F2/NR4A1/STAT3/VDR/PPARG	8
GO:0016846	carbon-sulfur lyase activity	3/2098	15/18367	0.241148253161219	0.570310531210394	ALOX5AP/MGST3/GLO1	3
GO:0045125	bioactive lipid receptor activity	3/2098	15/18367	0.241148253161219	0.570310531210394	LPAR6/S1PR4/SPHK1	3
GO:0048185	activin binding	3/2098	15/18367	0.241148253161219	0.570310531210394	ENG/FKBP1A/TGFBR3	3
GO:0051371	muscle alpha-actinin binding	3/2098	15/18367	0.241148253161219	0.570310531210394	PDLIM1/PDLIM7/PALLD	3
GO:0071933	Arp2/3 complex binding	3/2098	15/18367	0.241148253161219	0.570310531210394	GMFG/IQGAP2/WASF2	3
GO:1901611	phosphatidylglycerol binding	3/2098	15/18367	0.241148253161219	0.570310531210394	MME/STOML2/NME4	3
GO:1990825	sequence-specific mRNA binding	3/2098	15/18367	0.241148253161219	0.570310531210394	TYMS/DHFR/SRSF4	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	17/2098	124/18367	0.247621676104658	0.584387155606993	LDHB/AKR7A2/KCNAB2/HSD17B1/ADH5/IDH2/HPGD/AKR1B1/DCXR/LDHA/HADH/GRHPR/GCLM/HSD17B11/MDH1/IDH1/IMPDH2	17
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	7/2098	45/18367	0.250145197520798	0.589102450463896	FEN1/POP7/RNASEH2A/DNASE1L1/APEX1/AGO2/EXO1	7
GO:0005343	organic acid:sodium symporter activity	5/2098	30/18367	0.253749245049605	0.593847398122354	SLC38A1/SLC6A6/SLC13A3/SLC1A3/SLC10A3	5
GO:0022829	wide pore channel activity	5/2098	30/18367	0.253749245049605	0.593847398122354	GJA1/GJA5/TOMM40/VDAC1/VDAC3	5
GO:0046966	thyroid hormone receptor binding	5/2098	30/18367	0.253749245049605	0.593847398122354	OASL/FUS/HMGN3/TRIP6/ARID5A	5
GO:1901505	carbohydrate derivative transmembrane transporter activity	8/2098	53/18367	0.254880256141721	0.595251598197645	SLC25A5/SLC29A1/SLC15A3/SLC35B4/SLC25A4/SLC19A1/SLC25A17/SLC25A6	8
GO:0015179	L-amino acid transmembrane transporter activity	9/2098	61/18367	0.257935013640637	0.599886203923555	SLC7A7/SLC38A1/SLC1A5/SFXN1/SLC7A6/SLC38A9/SLC38A6/SLC3A2/SLC1A3	9
GO:0043621	protein self-association	9/2098	61/18367	0.257935013640637	0.599886203923555	TNFAIP3/SLC2A1/RSAD2/ADAM8/NLRP1/MYD88/SVIP/GPSM2/PPARG	9
GO:0004721	phosphoprotein phosphatase activity	23/2098	174/18367	0.258897742195359	0.60087861076811	PTPRC/DUSP1/LRRK2/DUSP9/PGP/DUSP2/PTPN6/CTDSPL/PPM1G/PTPN14/DUSP14/DUSP18/PTPRF/DUSP5/CAMK2G/PHPT1/DLG1/PTP4A2/PTPN3/UBASH3B/CTDSPL2/PTPRU/ILKAP	23
GO:0004521	endoribonuclease activity	10/2098	69/18367	0.259825776778402	0.601786561505349	FEN1/RNASET2/POP7/RNASEH2A/TSEN34/SND1/APEX1/AGO2/EXO1/LACTB2	10
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	6/2098	38/18367	0.262846119838117	0.607504699276036	PPIA/PPIB/PPIC/FKBP5/FKBP3/FKBP1A	6
GO:0009931	calcium-dependent protein serine/threonine kinase activity	4/2098	23/18367	0.264462349015795	0.607504699276036	CCL3/PRKCB/MAPKAPK3/PKN1	4
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4/2098	23/18367	0.264462349015795	0.607504699276036	ALOX5AP/ALOX5/ADI1/CDO1	4
GO:1901567	fatty acid derivative binding	4/2098	23/18367	0.264462349015795	0.607504699276036	DBI/ACBD6/ACADVL/ECI2	4
GO:0004698	calcium-dependent protein kinase C activity	3/2098	16/18367	0.273494178153514	0.61811889860905	CCL3/PRKCB/PKN1	3
GO:0005521	lamin binding	3/2098	16/18367	0.273494178153514	0.61811889860905	TMPO/IFI27/BNIP3L	3
GO:0005523	tropomyosin binding	3/2098	16/18367	0.273494178153514	0.61811889860905	PYCARD/S100A6/CALD1	3
GO:0016208	AMP binding	3/2098	16/18367	0.273494178153514	0.61811889860905	FBP1/ACSS1/PRKAG2	3
GO:0032183	SUMO binding	3/2098	16/18367	0.273494178153514	0.61811889860905	SERBP1/CBX4/CASP8AP2	3
GO:0070402	NADPH binding	3/2098	16/18367	0.273494178153514	0.61811889860905	DHFR/GRHPR/QDPR	3
GO:0070403	NAD+ binding	3/2098	16/18367	0.273494178153514	0.61811889860905	HPGD/UXS1/HADH	3
GO:1990380	Lys48-specific deubiquitinase activity	3/2098	16/18367	0.273494178153514	0.61811889860905	USP15/USP27X/DESI2	3
GO:0001098	basal transcription machinery binding	10/2098	70/18367	0.274648874871439	0.618235720343139	RTF1/SMYD2/NOP58/BRD4/ZNF326/ERCC1/AGO2/DRAP1/FBL/URI1	10
GO:0001099	basal RNA polymerase II transcription machinery binding	10/2098	70/18367	0.274648874871439	0.618235720343139	RTF1/SMYD2/NOP58/BRD4/ZNF326/ERCC1/AGO2/DRAP1/FBL/URI1	10
GO:0043015	gamma-tubulin binding	5/2098	31/18367	0.276516147220303	0.621191585238396	LYN/BRCA2/CENPJ/NME1/NDRG1	5
GO:0016776	phosphotransferase activity, phosphate group as acceptor	6/2098	39/18367	0.283227121725036	0.634995206907531	DTYMK/PMVK/NME4/DLG1/MPP1/NME1	6
GO:0032182	ubiquitin-like protein binding	15/2098	111/18367	0.283812131706673	0.635036725834691	CXCR4/UBE2L6/TNFAIP3/TOP2A/CKS1B/SERBP1/CKS2/N4BP2/CBX4/BUB3/CASP8AP2/UBXN2A/RAD23B/RNF8/UBE2N	15
GO:0016798	hydrolase activity, acting on glycosyl bonds	19/2098	144/18367	0.286721552404002	0.639574951971076	LYZ/PIK3AP1/TLR2/PCNA/TLR1/TLR4/TLR6/TLR7/AGL/UNG/HPSE/TLR8/FUCA1/MYD88/GANAB/APEX1/GAA/HEXB/DNPH1	19
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	7/2098	47/18367	0.286981445888895	0.639574951971076	DUSP1/DUSP9/DUSP2/DUSP14/DUSP18/DUSP5/PTP4A2	7
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	18/2098	136/18367	0.289049786284997	0.642430128989207	LDHB/AKR7A2/KCNAB2/HSD17B1/ADH5/IDH2/HPGD/AKR1B1/DCXR/LDHA/HADH/GRHPR/GCLM/HSD17B11/MDH1/IDH1/IMPDH2/VKORC1	18
GO:0008171	O-methyltransferase activity	4/2098	24/18367	0.291128015634716	0.642430128989207	COMT/ICMT/COMTD1/LCMT1	4
GO:0010857	calcium-dependent protein kinase activity	4/2098	24/18367	0.291128015634716	0.642430128989207	CCL3/PRKCB/MAPKAPK3/PKN1	4
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	4/2098	24/18367	0.291128015634716	0.642430128989207	ALOX5AP/ALOX5/ADI1/CDO1	4
GO:0043274	phospholipase binding	4/2098	24/18367	0.291128015634716	0.642430128989207	WAS/BTK/SYK/LMNB1	4
GO:0046982	protein heterodimerization activity	41/2098	328/18367	0.292239114944317	0.643615025250648	CYBB/BCL2A1/CYBA/MEF2C/IRAK3/TLR4/NR4A2/P4HB/CEBPB/TLR6/MEF2A/TOP2A/RAN/CENPW/TENM3/ITGB1/SMC3/NR4A1/PHB2/NAE1/MCL1/EPAS1/ADRB1/BARD1/LSM5/BHLHE40/SDCBP/JAM3/POLE3/TCOF1/PHB/SAE1/NFYB/YWHAE/DGKD/TOP2B/ATF3/KRT10/BHLHE41/DRAP1/PDGFA	41
GO:0001664	G protein-coupled receptor binding	37/2098	295/18367	0.296684691776841	0.652124587219291	CCL3L3/CCL3/FCN1/FPR1/CCL4/FLNA/JAK2/HOMER3/CXCL16/STAT1/WLS/GNAS/CCR2/ARRB2/CXCL10/C3/JAK1/CCRL2/ITGB4/MARCO/GNA15/RNF43/CX3CR1/CXCL8/HSPA8/GNAI2/C1QBP/ADRB1/STAT3/SDCBP/PHB/GNA11/GNAI1/HSPA1A/DEFB1/ZNRF3/HOMER1	37
GO:0003925	G protein activity	6/2098	40/18367	0.303936887430361	0.662733301114507	HRAS/RHOA/RALB/RAP1A/RIT1/RAC3	6
GO:0017080	sodium channel regulator activity	6/2098	40/18367	0.303936887430361	0.662733301114507	FXYD5/FXYD3/SGK1/CAMK2D/COMMD1/PTPN3	6
GO:0016879	ligase activity, forming carbon-nitrogen bonds	7/2098	48/18367	0.305858775137594	0.662733301114507	GLUL/PAICS/GCLM/GMPS/ASS1/RIMKLB/ASNSD1	7
GO:0004697	protein kinase C activity	3/2098	17/18367	0.306240722548898	0.662733301114507	CCL3/PRKCB/PKN1	3
GO:0008381	mechanosensitive ion channel activity	3/2098	17/18367	0.306240722548898	0.662733301114507	TMC6/TMC5/TMEM150C	3
GO:0008484	sulfuric ester hydrolase activity	3/2098	17/18367	0.306240722548898	0.662733301114507	SULF2/IDS/STS	3
GO:0015174	basic amino acid transmembrane transporter activity	3/2098	17/18367	0.306240722548898	0.662733301114507	SLC7A7/SLC7A6/SLC38A9	3
GO:0031489	myosin V binding	3/2098	17/18367	0.306240722548898	0.662733301114507	FUS/RAB3D/RAB25	3
GO:0019888	protein phosphatase regulator activity	12/2098	89/18367	0.315825656174949	0.663999741354752	PHACTR1/LGALS3/SET/PPP1R14B/CALM2/PHACTR2/PPP1R15A/ENSA/B3GAT3/PTN/PPP1R35/URI1	12
GO:0005112	Notch binding	4/2098	25/18367	0.318124093041644	0.663999741354752	GALNT11/NOTCH1/AAK1/NCOR2	4
GO:0120227	acyl-CoA binding	4/2098	25/18367	0.318124093041644	0.663999741354752	DBI/ACBD6/ACADVL/ECI2	4
GO:0035591	signaling adaptor activity	11/2098	81/18367	0.318241831484837	0.663999741354752	DOK2/LRRK2/PAG1/SH2B3/STAT3/DLG5/EPS8/GNB4/HOMER1/MPP7/LDLRAP1	11
GO:0005201	extracellular matrix structural constituent	22/2098	172/18367	0.319024371228179	0.663999741354752	FGL2/VCAN/TGFBI/FBLN1/EFEMP1/FN1/COL14A1/FBN2/CD4/FBN1/TINAGL1/VWA1/LAMB1/EMILIN2/LAMA5/COL4A2/LAMC1/MFAP5/LTBP1/FRAS1/COL4A1/COL21A1	22
GO:0005031	tumor necrosis factor-activated receptor activity	2/2098	10/18367	0.319264817654069	0.663999741354752	TNFRSF1B/TNFRSF14	2
GO:0005384	manganese ion transmembrane transporter activity	2/2098	10/18367	0.319264817654069	0.663999741354752	SLC11A1/TRPM2	2
GO:0005432	calcium:sodium antiporter activity	2/2098	10/18367	0.319264817654069	0.663999741354752	SLC8A1/SLC3A2	2
GO:0008190	eukaryotic initiation factor 4E binding	2/2098	10/18367	0.319264817654069	0.663999741354752	HHEX/EIF4G1	2
GO:0008641	ubiquitin-like modifier activating enzyme activity	2/2098	10/18367	0.319264817654069	0.663999741354752	NAE1/SAE1	2
GO:0016595	glutamate binding	2/2098	10/18367	0.319264817654069	0.663999741354752	GLUL/SLC1A3	2
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	2/2098	10/18367	0.319264817654069	0.663999741354752	CYB5R4/CYB5R1	2
GO:0016783	sulfurtransferase activity	2/2098	10/18367	0.319264817654069	0.663999741354752	TSTD1/MOCS2	2
GO:0016803	ether hydrolase activity	2/2098	10/18367	0.319264817654069	0.663999741354752	AKR7A2/LTA4H	2
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2/2098	10/18367	0.319264817654069	0.663999741354752	GMPS/ASNSD1	2
GO:0030957	Tat protein binding	2/2098	10/18367	0.319264817654069	0.663999741354752	ACTB/NPM1	2
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/2098	10/18367	0.319264817654069	0.663999741354752	SLC27A2/ACSL4	2
GO:0045294	alpha-catenin binding	2/2098	10/18367	0.319264817654069	0.663999741354752	VCL/NUMB	2
GO:0048256	flap endonuclease activity	2/2098	10/18367	0.319264817654069	0.663999741354752	FEN1/EXO1	2
GO:0051880	G-quadruplex DNA binding	2/2098	10/18367	0.319264817654069	0.663999741354752	BLM/RAD50	2
GO:0070008	serine-type exopeptidase activity	2/2098	10/18367	0.319264817654069	0.663999741354752	TPP1/SCPEP1	2
GO:0003774	cytoskeletal motor activity	15/2098	114/18367	0.320353182708211	0.664066815128745	MYO1F/MYO1G/MYH10/SMC3/KIF23/MYL6/KIF21A/MYO1C/KIF20B/KIF22/MYO5A/KIF4A/KIF11/MYO7A/KIFC1	15
GO:0070063	RNA polymerase binding	10/2098	73/18367	0.320481843875692	0.664066815128745	ZFP36/PPIB/RTF1/BRCA1/SMYD2/BRD4/ZNF326/AGO2/PABPN1/URI1	10
GO:0019239	deaminase activity	5/2098	33/18367	0.323115192610247	0.667057331337177	APOBEC3A/CDA/APOBEC3G/APOBEC3C/AMPD3	5
GO:0140323	solute:anion antiporter activity	5/2098	33/18367	0.323115192610247	0.667057331337177	SLC26A2/SLC25A5/SLC25A4/SLC19A1/SLC25A6	5
GO:0016877	ligase activity, forming carbon-sulfur bonds	6/2098	41/18367	0.324903489164006	0.668287727252938	SLC27A2/ACSS1/NAE1/ACSL4/SAE1/SUCLG1	6
GO:0030331	estrogen receptor binding	6/2098	41/18367	0.324903489164006	0.668287727252938	PCNA/PARP1/FUS/PHB2/ISL1/ARID5A	6
GO:0017022	myosin binding	10/2098	74/18367	0.336120364552499	0.688676499819399	CXCR4/CORO1A/PYCARD/FUS/CALD1/RHOA/RAB3D/RAB25/DMD/TRIOBP	10
GO:0019208	phosphatase regulator activity	14/2098	107/18367	0.336478865080274	0.688676499819399	ZEB2/PHACTR1/LGALS3/BMP2K/SET/PPP1R14B/CALM2/PHACTR2/PPP1R15A/ENSA/B3GAT3/PTN/PPP1R35/URI1	14
GO:0043022	ribosome binding	9/2098	66/18367	0.339091363333107	0.688676499819399	RPSA/RPN2/CCDC47/HSPA5/SERBP1/C1QBP/SBDS/OLA1/TMEM147	9
GO:0004550	nucleoside diphosphate kinase activity	3/2098	18/18367	0.339116349598848	0.688676499819399	DTYMK/NME4/NME1	3
GO:0004708	MAP kinase kinase activity	3/2098	18/18367	0.339116349598848	0.688676499819399	PBK/MAPKAPK3/MAPK14	3
GO:0042834	peptidoglycan binding	3/2098	18/18367	0.339116349598848	0.688676499819399	TLR2/NLRP3/TREM2	3
GO:0055102	lipase inhibitor activity	3/2098	18/18367	0.339116349598848	0.688676499819399	ANXA5/APOC1/ANXA3	3
GO:0004364	glutathione transferase activity	4/2098	26/18367	0.345299196982659	0.698701082703178	ALOX5AP/GSTP1/MGST1/PTGES	4
GO:0008198	ferrous iron binding	4/2098	26/18367	0.345299196982659	0.698701082703178	FTH1/FTL/CDO1/ACP5	4
GO:0043130	ubiquitin binding	12/2098	92/18367	0.358352959265649	0.710308176897411	CXCR4/UBE2L6/TNFAIP3/TOP2A/CKS1B/CKS2/N4BP2/BUB3/UBXN2A/RAD23B/RNF8/UBE2N	12
GO:0004518	nuclease activity	26/2098	210/18367	0.361567402232813	0.710308176897411	SAMHD1/ISG20/RNASE6/RPS3/FEN1/RNASET2/POP7/RAD51C/RNASEH2A/N4BP2/TSEN34/PLSCR1/RAD50/PNKP/SND1/DNASE1L1/APEX1/MGME1/DDX1/ERCC1/AGO2/RBBP8/NME1/EXO1/TOE1/LACTB2	26
GO:0015171	amino acid transmembrane transporter activity	11/2098	84/18367	0.362979642975245	0.710308176897411	SLC7A7/SLC38A1/SLC6A6/SLC1A5/SFXN3/SFXN1/SLC7A6/SLC38A9/SLC38A6/SLC3A2/SLC1A3	11
GO:0008503	benzodiazepine receptor activity	2/2098	11/18367	0.363074563213395	0.710308176897411	TSPO/GABRE	2
GO:0015368	calcium:cation antiporter activity	2/2098	11/18367	0.363074563213395	0.710308176897411	SLC8A1/SLC3A2	2
GO:0016801	hydrolase activity, acting on ether bonds	2/2098	11/18367	0.363074563213395	0.710308176897411	AKR7A2/LTA4H	2
GO:0016832	aldehyde-lyase activity	2/2098	11/18367	0.363074563213395	0.710308176897411	ALDOA/SHMT1	2
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	2/2098	11/18367	0.363074563213395	0.710308176897411	FUOM/DSE	2
GO:0031434	mitogen-activated protein kinase kinase binding	2/2098	11/18367	0.363074563213395	0.710308176897411	TRIB1/DLG1	2
GO:0043295	glutathione binding	2/2098	11/18367	0.363074563213395	0.710308176897411	MGST1/PTGES	2
GO:0043522	leucine zipper domain binding	2/2098	11/18367	0.363074563213395	0.710308176897411	PAWR/PMF1	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/2098	11/18367	0.363074563213395	0.710308176897411	GLRX/TXN	2
GO:0047676	arachidonate-CoA ligase activity	2/2098	11/18367	0.363074563213395	0.710308176897411	SLC27A2/ACSL4	2
GO:0048407	platelet-derived growth factor binding	2/2098	11/18367	0.363074563213395	0.710308176897411	COL4A1/PDGFA	2
GO:0051400	BH domain binding	2/2098	11/18367	0.363074563213395	0.710308176897411	BCL2A1/MCL1	2
GO:0061665	SUMO ligase activity	2/2098	11/18367	0.363074563213395	0.710308176897411	CBX4/ZNF451	2
GO:0097371	MDM2/MDM4 family protein binding	2/2098	11/18367	0.363074563213395	0.710308176897411	RPL37/RPS20	2
GO:0099186	structural constituent of postsynapse	2/2098	11/18367	0.363074563213395	0.710308176897411	ACTB/DLG1	2
GO:0140036	ubiquitin-dependent protein binding	2/2098	11/18367	0.363074563213395	0.710308176897411	LAPTM5/USP15	2
GO:0004129	cytochrome-c oxidase activity	3/2098	19/18367	0.371878652576046	0.718735806681903	COX6A1/CYB5A/COX5A	3
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	3/2098	19/18367	0.371878652576046	0.718735806681903	ENG/LTBP1/TGFBR3	3
GO:0010314	phosphatidylinositol-5-phosphate binding	3/2098	19/18367	0.371878652576046	0.718735806681903	PHLDA3/PLEKHA5/SNX24	3
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	3/2098	19/18367	0.371878652576046	0.718735806681903	DHFR/PYCR2/QDPR	3
GO:0008139	nuclear localization sequence binding	4/2098	27/18367	0.372511600073314	0.718735806681903	NFKBIA/NUP214/KPNB1/IPO5	4
GO:0015491	cation:cation antiporter activity	4/2098	27/18367	0.372511600073314	0.718735806681903	SLC11A1/SLC8A1/SLC9A1/SLC3A2	4
GO:0045499	chemorepellent activity	4/2098	27/18367	0.372511600073314	0.718735806681903	DPP4/SEMA4A/SEMA6A/SEMA6D	4
GO:0051959	dynein light intermediate chain binding	4/2098	27/18367	0.372511600073314	0.718735806681903	CCDC88A/DYNLL2/CCDC88B/HOOK2	4
GO:0001786	phosphatidylserine binding	8/2098	60/18367	0.377866810729944	0.727815626852693	CD300A/HMGB1/CD300LF/MME/TREM2/HSPA8/SYT7/SCIN	8
GO:0016597	amino acid binding	7/2098	52/18367	0.383180075588029	0.736783644484016	GLUL/DDAH2/GLDC/ASS1/SHMT1/GCHFR/SLC1A3	7
GO:0004629	phospholipase C activity	4/2098	28/18367	0.399630154500094	0.743235039902618	CCR1/PDIA3/PLCB2/NOTUM	4
GO:0017056	structural constituent of nuclear pore	4/2098	28/18367	0.399630154500094	0.743235039902618	NUP214/UPF3A/TPR/NUP54	4
GO:0046875	ephrin receptor binding	4/2098	28/18367	0.399630154500094	0.743235039902618	LYN/SDCBP/GRB2/EFNA1	4
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4/2098	28/18367	0.399630154500094	0.743235039902618	PHLDA3/COMMD1/PLEKHA5/WIPI2	4
GO:0050661	NADP binding	7/2098	53/18367	0.402703961155946	0.743235039902618	DPYD/HSD17B1/DHFR/GRHPR/IDH1/QDPR/GAPDH	7
GO:0001972	retinoic acid binding	3/2098	20/18367	0.404314399685779	0.743235039902618	RARA/NR2F2/FABP5	3
GO:0016018	cyclosporin A binding	3/2098	20/18367	0.404314399685779	0.743235039902618	PPIA/PPIB/PPIC	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/2098	20/18367	0.404314399685779	0.743235039902618	COX6A1/CYB5A/COX5A	3
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	3/2098	20/18367	0.404314399685779	0.743235039902618	CHPT1/CDS1/CDIPT	3
GO:0019211	phosphatase activator activity	3/2098	20/18367	0.404314399685779	0.743235039902618	CALM2/PPP1R15A/B3GAT3	3
GO:0035014	phosphatidylinositol 3-kinase regulator activity	3/2098	20/18367	0.404314399685779	0.743235039902618	KLF4/SOCS3/PIK3R5	3
GO:0050145	nucleoside monophosphate kinase activity	3/2098	20/18367	0.404314399685779	0.743235039902618	DTYMK/DLG1/MPP1	3
GO:0097001	ceramide binding	3/2098	20/18367	0.404314399685779	0.743235039902618	PSAP/CD300LF/VDAC1	3
GO:0000340	RNA 7-methylguanosine cap binding	2/2098	12/18367	0.405762573077968	0.743235039902618	NCBP3/AGO2	2
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/2098	12/18367	0.405762573077968	0.743235039902618	RPS3/APEX1	2
GO:0003995	acyl-CoA dehydrogenase activity	2/2098	12/18367	0.405762573077968	0.743235039902618	TECR/ACADVL	2
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	2/2098	12/18367	0.405762573077968	0.743235039902618	AKR7A2/AKR1B1	2
GO:0008296	3'-5'-exodeoxyribonuclease activity	2/2098	12/18367	0.405762573077968	0.743235039902618	ISG20/APEX1	2
GO:0015269	calcium-activated potassium channel activity	2/2098	12/18367	0.405762573077968	0.743235039902618	KCNMB1/KCNN4	2
GO:0017166	vinculin binding	2/2098	12/18367	0.405762573077968	0.743235039902618	DAG1/DMD	2
GO:0022858	alanine transmembrane transporter activity	2/2098	12/18367	0.405762573077968	0.743235039902618	SLC6A6/SLC3A2	2
GO:0031543	peptidyl-proline dioxygenase activity	2/2098	12/18367	0.405762573077968	0.743235039902618	P4HB/P3H1	2
GO:0033130	acetylcholine receptor binding	2/2098	12/18367	0.405762573077968	0.743235039902618	JAK2/UBXN2A	2
GO:0035256	G protein-coupled glutamate receptor binding	2/2098	12/18367	0.405762573077968	0.743235039902618	HOMER3/HOMER1	2
GO:0042975	peroxisome proliferator activated receptor binding	2/2098	12/18367	0.405762573077968	0.743235039902618	HMGA1/ASXL1	2
GO:0045295	gamma-catenin binding	2/2098	12/18367	0.405762573077968	0.743235039902618	CDH1/DSC3	2
GO:0046790	virion binding	2/2098	12/18367	0.405762573077968	0.743235039902618	PPIA/SIGLEC1	2
GO:1900750	oligopeptide binding	2/2098	12/18367	0.405762573077968	0.743235039902618	MGST1/PTGES	2
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	2/2098	12/18367	0.405762573077968	0.743235039902618	KCNQ1/KCNE3	2
GO:0022853	active ion transmembrane transporter activity	32/2098	267/18367	0.413977417486987	0.757045163136889	SLC11A1/SLC8A1/SLC38A1/SLC26A2/COX6A1/CYB5A/SLC25A5/ATP6V1F/ATP2B1/SLC25A3/SLC15A3/SLC6A6/SLC22A11/ATP6V1C2/SLC25A1/SLC6A4/SLC13A4/SLC25A4/SLC19A1/SLC20A1/SLC9A1/SLC13A3/CYC1/UQCR10/ATP6V1B2/COX5A/UQCRFS1/ATP6V0E1/SLC25A6/SLC3A2/SLC1A3/SLC10A3	32
GO:0071949	FAD binding	5/2098	37/18367	0.417843877505482	0.762871313817012	QSOX1/DHCR24/SQLE/KDM1B/CYB5R1	5
GO:1990782	protein tyrosine kinase binding	13/2098	105/18367	0.423097911467084	0.77120773781236	DOK2/PCNA/CD4/DOCK4/HSP90AA1/ITGAX/ITGB1/TREM2/SH2B3/DAZAP2/PTPN14/SIRPA/EIF3A	13
GO:0019842	vitamin binding	18/2098	148/18367	0.42610835171284	0.774952357369896	TYMS/SDS/KYNU/TCN2/DHFR/GLDC/SDSL/VDR/OAT/FOLR1/SLC19A1/DHTKD1/PLOD2/SHMT1/MMAB/P3H1/MTR/CD320	18
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	4/2098	29/18367	0.426534883583609	0.774952357369896	IL4I1/DHFR/PYCR2/QDPR	4
GO:0140296	general transcription initiation factor binding	6/2098	46/18367	0.431189772902468	0.782141966704963	HHEX/NOP58/ERCC1/BDP1/DRAP1/FBL	6
GO:0005385	zinc ion transmembrane transporter activity	3/2098	21/18367	0.436238829476141	0.790022177451946	SLC39A10/SLC39A1/SLC39A7	3
GO:0008235	metalloexopeptidase activity	9/2098	72/18367	0.440548666336044	0.794139706428017	QPCT/LAP3/VASH1/ENPEP/ANPEP/LTA4H/DPEP2/TFRC/MMP15	9
GO:0004722	protein serine/threonine phosphatase activity	12/2098	98/18367	0.445234322019742	0.794139706428017	DUSP1/LRRK2/DUSP9/DUSP2/CTDSPL/PPM1G/DUSP14/DUSP18/DUSP5/CAMK2G/CTDSPL2/ILKAP	12
GO:0004867	serine-type endopeptidase inhibitor activity	12/2098	98/18367	0.445234322019742	0.794139706428017	SERPINA1/ITIH5/SPINT1/SPINT2/PEBP1/SERPINF1/APP/APLP2/CRIM1/SERPINH1/SERPINB8/SERPING1	12
GO:0005035	death receptor activity	2/2098	13/18367	0.447013518961712	0.794139706428017	TNFRSF1B/TNFRSF14	2
GO:0008179	adenylate cyclase binding	2/2098	13/18367	0.447013518961712	0.794139706428017	CAP1/CALM2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/2098	13/18367	0.447013518961712	0.794139706428017	SLC26A2/SLC13A4	2
GO:0031432	titin binding	2/2098	13/18367	0.447013518961712	0.794139706428017	CAMK2D/CALM2	2
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	2/2098	13/18367	0.447013518961712	0.794139706428017	CKS1B/CKS2	2
GO:0070700	BMP receptor binding	2/2098	13/18367	0.447013518961712	0.794139706428017	PYCARD/BMP7	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/2098	13/18367	0.447013518961712	0.794139706428017	HSD17B1/HSD17B11	2
GO:0140035	ubiquitination-like modification-dependent protein binding	2/2098	13/18367	0.447013518961712	0.794139706428017	LAPTM5/USP15	2
GO:0140299	small molecule sensor activity	2/2098	13/18367	0.447013518961712	0.794139706428017	PARK7/EFHD1	2
GO:0005310	dicarboxylic acid transmembrane transporter activity	4/2098	30/18367	0.453117289511918	0.803709622694398	SLC26A2/SLC1A5/SLC19A1/SLC13A3	4
GO:0004540	ribonuclease activity	14/2098	116/18367	0.456083951525484	0.807531439208063	SAMHD1/ISG20/RNASE6/FEN1/RNASET2/POP7/RNASEH2A/TSEN34/SND1/APEX1/AGO2/EXO1/TOE1/LACTB2	14
GO:0106306	protein serine phosphatase activity	9/2098	73/18367	0.457433063244532	0.807531439208063	DUSP1/DUSP9/DUSP2/CTDSPL/PPM1G/DUSP14/DUSP18/DUSP5/ILKAP	9
GO:0106307	protein threonine phosphatase activity	9/2098	73/18367	0.457433063244532	0.807531439208063	DUSP1/DUSP9/DUSP2/CTDSPL/PPM1G/DUSP14/DUSP18/DUSP5/ILKAP	9
GO:0030374	nuclear receptor coactivator activity	7/2098	56/18367	0.460965824226998	0.812488504651673	PRKCB/HMGA1/PSMC3IP/USP22/PKN1/ACTN4/DCAF6	7
GO:0106310	protein serine kinase activity	42/2098	360/18367	0.466551581117907	0.813759676290004	LRRK2/SGK1/PRKDC/PLK3/CAMK1D/CAMK1/CIITA/CDK1/VRK1/BMP2K/PRKCB/CAMK2D/PBK/CHEK1/NRK/AAK1/MAP3K2/PKMYT1/RPS6KA1/MAPKAPK3/MAP3K8/CDK4/STK17A/CDK6/SRPK1/EIF2AK4/TTK/CAMK2G/MASTL/STK17B/EIF2AK1/PAK6/CDK2/AURKB/TLK1/STK4/PLK2/MAP3K4/RPS6KA5/PKN1/BUB1B/MAPK14	42
GO:0005355	glucose transmembrane transporter activity	3/2098	22/18367	0.467494408145194	0.813759676290004	SLC2A3/SLC2A1/SLC2A6	3
GO:0005537	mannose binding	3/2098	22/18367	0.467494408145194	0.813759676290004	LMAN1/CLEC4A/BSG	3
GO:0008093	cytoskeletal anchor activity	3/2098	22/18367	0.467494408145194	0.813759676290004	SDCBP/ANK3/OBSL1	3
GO:0008320	protein transmembrane transporter activity	3/2098	22/18367	0.467494408145194	0.813759676290004	MCL1/TOMM40/SEC63	3
GO:0015149	hexose transmembrane transporter activity	3/2098	22/18367	0.467494408145194	0.813759676290004	SLC2A3/SLC2A1/SLC2A6	3
GO:0017075	syntaxin-1 binding	3/2098	22/18367	0.467494408145194	0.813759676290004	LRRK2/STXBP2/SLC6A4	3
GO:0070034	telomerase RNA binding	3/2098	22/18367	0.467494408145194	0.813759676290004	SNRPB/NHP2/SNRPD3	3
GO:0016878	acid-thiol ligase activity	4/2098	31/18367	0.479280421703268	0.831692496485083	SLC27A2/ACSS1/ACSL4/SUCLG1	4
GO:0042910	xenobiotic transmembrane transporter activity	4/2098	31/18367	0.479280421703268	0.831692496485083	SLC2A1/SLC6A6/SLC19A1/EBP	4
GO:0004065	arylsulfatase activity	2/2098	14/18367	0.486598679400456	0.836621349091889	SULF2/STS	2
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/2098	14/18367	0.486598679400456	0.836621349091889	DOK2/SH2B3	2
GO:0015373	anion:sodium symporter activity	2/2098	14/18367	0.486598679400456	0.836621349091889	SLC6A4/SLC13A4	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/2098	14/18367	0.486598679400456	0.836621349091889	HSD17B1/HSD17B11	2
GO:0071837	HMG box domain binding	2/2098	14/18367	0.486598679400456	0.836621349091889	GATA3/JUN	2
GO:0140666	annealing activity	2/2098	14/18367	0.486598679400456	0.836621349091889	SMARCA1/BLM	2
GO:0008009	chemokine activity	6/2098	49/18367	0.493897646017191	0.846573793861271	CCL3L3/CCL3/CCL4/CXCL16/CXCL10/CXCL8	6
GO:0043539	protein serine/threonine kinase activator activity	6/2098	49/18367	0.493897646017191	0.846573793861271	CKS1B/DAZAP2/CKS2/CALM2/DBF4/STK4	6
GO:0030165	PDZ domain binding	10/2098	84/18367	0.4953012114898	0.847683447450482	DOCK4/CADM1/CRIM1/ATP2B1/GJA1/PLEKHA2/ADRB1/GNG12/TGFBR3/PLEKHA1	10
GO:0005158	insulin receptor binding	3/2098	23/18367	0.497949217014604	0.848329897071993	CCDC88A/SNX4/IGF1R	3
GO:0030215	semaphorin receptor binding	3/2098	23/18367	0.497949217014604	0.848329897071993	SEMA4A/SEMA6A/SEMA6D	3
GO:0140103	catalytic activity, acting on a glycoprotein	3/2098	23/18367	0.497949217014604	0.848329897071993	FUT8/C1GALT1/C1GALT1C1	3
GO:0051721	protein phosphatase 2A binding	4/2098	32/18367	0.504938746825995	0.858932223356511	STAT1/SPHK1/MASTL/ENSA	4
GO:0050660	flavin adenine dinucleotide binding	10/2098	85/18367	0.510929192325135	0.867805491812842	CYBB/DPYD/QSOX1/DHCR24/ACADVL/SQLE/ETFA/KDM1B/CYB5R1/SDHA	10
GO:0000993	RNA polymerase II complex binding	6/2098	50/18367	0.514302425481292	0.868585718486708	RTF1/SMYD2/BRD4/ZNF326/AGO2/URI1	6
GO:0005048	signal sequence binding	6/2098	50/18367	0.514302425481292	0.868585718486708	NFKBIA/NUP214/KPNB1/IPO5/AP2M1/KDELR2	6
GO:0030159	signaling receptor complex adaptor activity	6/2098	50/18367	0.514302425481292	0.868585718486708	DOK2/LRRK2/SH2B3/DLG5/GNB4/LDLRAP1	6
GO:0016757	glycosyltransferase activity	31/2098	270/18367	0.516609399627578	0.868585718486708	TYMP/UPP1/PARP1/NAMPT/RPN2/AGL/ST3GAL5/GALNT11/QPRT/PARP9/LFNG/EXTL2/CHPF/MFNG/MTAP/UMPS/PNP/FUT8/C1GALT1/PARP2/TMTC3/GXYLT1/PARP14/GLT8D1/C1GALT1C1/B3GAT3/PARP12/HEXB/GALNT18/PPAT/ALG8	31
GO:0036002	pre-mRNA binding	7/2098	59/18367	0.517869451209074	0.868585718486708	CELF2/SLBP/SRSF2/HNRNPA1/SF1/TRA2B/PRPF8	7
GO:0005125	cytokine activity	27/2098	235/18367	0.517911830796709	0.868585718486708	TIMP1/CCL3L3/CCL3/TNFSF13B/TNFSF10/CCL4/TGFB1/HMGB1/SECTM1/SPP1/VEGFA/TNF/CXCL16/IL1B/NAMPT/IL1RN/GRN/CXCL10/BMP7/TNFSF12/IL16/VSTM1/CMTM3/CXCL8/FAM3B/CMTM8/IL18	27
GO:0016782	transferase activity, transferring sulphur-containing groups	8/2098	68/18367	0.521007657101339	0.868585718486708	TSTD1/HS3ST1/SULT1A1/CHST15/TPST2/CHST14/HS6ST2/MOCS2	8
GO:0004467	long-chain fatty acid-CoA ligase activity	2/2098	15/18367	0.524360283437262	0.868585718486708	SLC27A2/ACSL4	2
GO:0004549	tRNA-specific ribonuclease activity	2/2098	15/18367	0.524360283437262	0.868585718486708	POP7/TSEN34	2
GO:0010851	cyclase regulator activity	2/2098	15/18367	0.524360283437262	0.868585718486708	GNAS/CALM2	2
GO:0019215	intermediate filament binding	2/2098	15/18367	0.524360283437262	0.868585718486708	VIM/NME1	2
GO:0034483	heparan sulfate sulfotransferase activity	2/2098	15/18367	0.524360283437262	0.868585718486708	HS3ST1/HS6ST2	2
GO:0047372	acylglycerol lipase activity	2/2098	15/18367	0.524360283437262	0.868585718486708	ABHD2/MGLL	2
GO:0051139	metal ion:proton antiporter activity	2/2098	15/18367	0.524360283437262	0.868585718486708	SLC11A1/SLC9A1	2
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	2/2098	15/18367	0.524360283437262	0.868585718486708	KCNQ1/KCNE3	2
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	2/2098	15/18367	0.524360283437262	0.868585718486708	PYCARD/CASP1	2
GO:0042562	hormone binding	10/2098	86/18367	0.526411604807379	0.868585718486708	TSPO/EGFR/LRP2/SLC40A1/CTSH/CALR/ALDH1A1/ABHD2/IGF1R/INSR	10
GO:0015145	monosaccharide transmembrane transporter activity	3/2098	24/18367	0.527495102926017	0.868585718486708	SLC2A3/SLC2A1/SLC2A6	3
GO:0016769	transferase activity, transferring nitrogenous groups	3/2098	24/18367	0.527495102926017	0.868585718486708	OAT/GFPT1/GAPDH	3
GO:0019789	SUMO transferase activity	3/2098	24/18367	0.527495102926017	0.868585718486708	CBX4/ZNF451/TRIM28	3
GO:0001216	DNA-binding transcription activator activity	52/2098	456/18367	0.527660012747054	0.868585718486708	SPI1/MAFB/MEF2C/FOS/TFEC/KLF4/JUNB/KLF6/NR4A2/CEBPB/ELK3/RUNX1/MEF2A/STAT6/LITAF/TFDP2/HHEX/FLI1/NR4A1/IRF1/IRF5/FOSB/CEBPD/EPAS1/TFAP2A/KLF7/ISL1/STAT3/SOX4/GATA3/ATF5/PBX1/MYBL2/PLSCR1/KLF5/TFDP1/ZFAT/NFYB/BACH1/FOXO4/ELF1/JUN/ATMIN/TFCP2L1/ATF3/REL/FOXC1/TBX3/E2F1/NFAT5/TFAP2C/MEIS2	52
GO:0031369	translation initiation factor binding	4/2098	33/18367	0.530017857752306	0.869912179414838	HHEX/GCH1/EIF5/EIF4G1	4
GO:0051427	hormone receptor binding	4/2098	33/18367	0.530017857752306	0.869912179414838	JAK2/GNAS/JAK1/CSH1	4
GO:0008307	structural constituent of muscle	5/2098	42/18367	0.532284006223055	0.872354343532229	CSRP2/DAG1/ASPH/MYL6/DMD	5
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	7/2098	60/18367	0.536360365989337	0.877751781421966	DPYD/TECR/TBXAS1/DHCR24/ACADVL/AKR1B1/SDHA	7
GO:0003777	microtubule motor activity	8/2098	69/18367	0.538232991936469	0.87953233813525	SMC3/KIF23/KIF21A/KIF20B/KIF22/KIF4A/KIF11/KIFC1	8
GO:0001221	transcription coregulator binding	9/2098	78/18367	0.540018532239304	0.881165610830073	KLF4/LMO2/STAT1/TFAM/RPL23/EZH2/EPAS1/CBX3/SUZ12	9
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	51/2098	450/18367	0.546652155594329	0.888235208760411	SPI1/MAFB/MEF2C/FOS/TFEC/KLF4/JUNB/KLF6/NR4A2/CEBPB/ELK3/RUNX1/MEF2A/STAT6/LITAF/TFDP2/HHEX/FLI1/NR4A1/IRF1/IRF5/FOSB/CEBPD/EPAS1/TFAP2A/KLF7/ISL1/STAT3/SOX4/GATA3/ATF5/PBX1/MYBL2/PLSCR1/KLF5/TFDP1/ZFAT/NFYB/BACH1/FOXO4/ELF1/JUN/ATMIN/TFCP2L1/ATF3/REL/FOXC1/TBX3/NFAT5/TFAP2C/MEIS2	51
GO:0030544	Hsp70 protein binding	5/2098	43/18367	0.553988959043472	0.888235208760411	RPS3/SPN/ST13/DNAJB14/DNAJB9	5
GO:0008146	sulfotransferase activity	6/2098	52/18367	0.554107400720147	0.888235208760411	HS3ST1/SULT1A1/CHST15/TPST2/CHST14/HS6ST2	6
GO:0016830	carbon-carbon lyase activity	6/2098	52/18367	0.554107400720147	0.888235208760411	PAICS/ALDOA/UXS1/UMPS/SHMT1/PISD	6
GO:0031593	polyubiquitin modification-dependent protein binding	6/2098	52/18367	0.554107400720147	0.888235208760411	TNFAIP3/AGL/RAD23B/VCP/PRPF8/BRCC3	6
GO:1901682	sulfur compound transmembrane transporter activity	6/2098	52/18367	0.554107400720147	0.888235208760411	SLC26A2/GJA1/SLC6A6/SLC13A4/SLC13A3/SLC19A3	6
GO:0008376	acetylgalactosaminyltransferase activity	4/2098	34/18367	0.554454054849917	0.888235208760411	GALNT11/EXTL2/CHPF/GALNT18	4
GO:0016831	carboxy-lyase activity	4/2098	34/18367	0.554454054849917	0.888235208760411	PAICS/UXS1/UMPS/PISD	4
GO:0005227	calcium activated cation channel activity	3/2098	25/18367	0.556045695182977	0.888235208760411	CATSPER1/KCNMB1/KCNN4	3
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	2/2098	16/18367	0.560198298477797	0.888235208760411	CAPNS1/CAPN1	2
GO:0005159	insulin-like growth factor receptor binding	2/2098	16/18367	0.560198298477797	0.888235208760411	GNAS/INSR	2
GO:0005283	amino acid:sodium symporter activity	2/2098	16/18367	0.560198298477797	0.888235208760411	SLC38A1/SLC1A3	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/2098	16/18367	0.560198298477797	0.888235208760411	SLC1A5/SLC1A3	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/2098	16/18367	0.560198298477797	0.888235208760411	SLC1A5/SLC13A3	2
GO:0016004	phospholipase activator activity	2/2098	16/18367	0.560198298477797	0.888235208760411	CCL3/BTK	2
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	2/2098	16/18367	0.560198298477797	0.888235208760411	RAD51C/TSEN34	2
GO:0022848	acetylcholine-gated cation-selective channel activity	2/2098	16/18367	0.560198298477797	0.888235208760411	CHRNB1/CHRNA5	2
GO:0035497	cAMP response element binding	2/2098	16/18367	0.560198298477797	0.888235208760411	CREB5/JUN	2
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	2/2098	16/18367	0.560198298477797	0.888235208760411	SOCS3/PIK3R5	2
GO:0050700	CARD domain binding	2/2098	16/18367	0.560198298477797	0.888235208760411	CASP1/CARD16	2
GO:0015297	antiporter activity	10/2098	89/18367	0.571792888032791	0.905338739385253	SLC11A1/SLC8A1/SLC26A2/SLC25A5/SLC25A4/SLC19A1/SLC9A1/SLC7A6/SLC25A6/SLC3A2	10
GO:0022839	ion gated channel activity	5/2098	44/18367	0.575186607688113	0.909427626542137	CATSPER1/KCNMB1/KCNN4/TTYH3/BEST1	5
GO:0015298	solute:cation antiporter activity	4/2098	35/18367	0.578193829166134	0.912894764077798	SLC11A1/SLC8A1/SLC9A1/SLC3A2	4
GO:0003951	NAD+ kinase activity	2/2098	17/18367	0.594059308601651	0.92107950891072	SPHK1/DGKD	2
GO:0004659	prenyltransferase activity	2/2098	17/18367	0.594059308601651	0.92107950891072	FDPS/FDFT1	2
GO:0008308	voltage-gated anion channel activity	2/2098	17/18367	0.594059308601651	0.92107950891072	VDAC1/VDAC3	2
GO:0008574	plus-end-directed microtubule motor activity	2/2098	17/18367	0.594059308601651	0.92107950891072	KIF20B/KIF11	2
GO:0015095	magnesium ion transmembrane transporter activity	2/2098	17/18367	0.594059308601651	0.92107950891072	TUSC3/MRS2	2
GO:0015116	sulfate transmembrane transporter activity	2/2098	17/18367	0.594059308601651	0.92107950891072	SLC26A2/SLC13A4	2
GO:0015278	calcium-release channel activity	2/2098	17/18367	0.594059308601651	0.92107950891072	TRPM2/MCOLN3	2
GO:0016854	racemase and epimerase activity	2/2098	17/18367	0.594059308601651	0.92107950891072	FUOM/DSE	2
GO:0030275	LRR domain binding	2/2098	17/18367	0.594059308601651	0.92107950891072	PAWR/PMF1	2
GO:0034185	apolipoprotein binding	2/2098	17/18367	0.594059308601651	0.92107950891072	HSPD1/TREM2	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/2098	17/18367	0.594059308601651	0.92107950891072	C1GALT1/C1GALT1C1	2
GO:0050780	dopamine receptor binding	2/2098	17/18367	0.594059308601651	0.92107950891072	GNAS/ARRB2	2
GO:0052745	inositol phosphate phosphatase activity	2/2098	17/18367	0.594059308601651	0.92107950891072	IMPA2/INPP5D	2
GO:0048156	tau protein binding	5/2098	45/18367	0.595840519233863	0.922565223841382	ACTB/HSP90AA1/HSP90AB1/BAG2/PICALM	5
GO:0016407	acetyltransferase activity	10/2098	91/18367	0.600987170497725	0.929250507762689	LPCAT2/SAT1/HAT1/SPHK1/BRCA2/ESCO2/ACAT2/USP22/SAT2/NAT14	10
GO:0015370	solute:sodium symporter activity	8/2098	73/18367	0.604460303501052	0.933333333642809	SLC38A1/SLC6A6/SLC6A4/SLC13A4/SLC20A1/SLC13A3/SLC1A3/SLC10A3	8
GO:0016405	CoA-ligase activity	3/2098	27/18367	0.609912214959774	0.939164276057564	SLC27A2/ACSS1/ACSL4	3
GO:0051119	sugar transmembrane transporter activity	3/2098	27/18367	0.609912214959774	0.939164276057564	SLC2A3/SLC2A1/SLC2A6	3
GO:0030170	pyridoxal phosphate binding	6/2098	55/18367	0.610791854025678	0.939228626012051	SDS/KYNU/GLDC/SDSL/OAT/SHMT1	6
GO:0030145	manganese ion binding	7/2098	65/18367	0.623912333332109	0.949478169245898	SOD2/LAP3/FEN1/GLUL/EXTL2/NUDT8/CDIPT	7
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/2098	18/18367	0.625927178477002	0.949478169245898	HSD17B1/HSD17B11	2
GO:0005229	intracellular calcium activated chloride channel activity	2/2098	18/18367	0.625927178477002	0.949478169245898	TTYH3/BEST1	2
GO:0008409	5'-3' exonuclease activity	2/2098	18/18367	0.625927178477002	0.949478169245898	FEN1/EXO1	2
GO:0016755	aminoacyltransferase activity	2/2098	18/18367	0.625927178477002	0.949478169245898	QPCT/TGM2	2
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/2098	18/18367	0.625927178477002	0.949478169245898	DAZAP2/MARVELD3	2
GO:0045236	CXCR chemokine receptor binding	2/2098	18/18367	0.625927178477002	0.949478169245898	CXCL10/CXCL8	2
GO:0060229	lipase activator activity	2/2098	18/18367	0.625927178477002	0.949478169245898	CCL3/BTK	2
GO:0061778	intracellular chloride channel activity	2/2098	18/18367	0.625927178477002	0.949478169245898	TTYH3/BEST1	2
GO:0098918	structural constituent of synapse	2/2098	18/18367	0.625927178477002	0.949478169245898	ACTB/DLG1	2
GO:0042054	histone methyltransferase activity	6/2098	56/18367	0.628770977601519	0.951217632781786	EZH2/SUZ12/SMYD2/KMT5A/NTMT1/FBL	6
GO:0070279	vitamin B6 binding	6/2098	56/18367	0.628770977601519	0.951217632781786	SDS/KYNU/GLDC/SDSL/OAT/SHMT1	6
GO:0016791	phosphatase activity	30/2098	275/18367	0.634680857133966	0.958657500568488	PTPRC/DUSP1/LRRK2/FBP1/DUSP9/PGP/DUSP2/PTPN6/CTDSPL/PPM1G/PTPN14/DUSP14/PLPP3/DUSP18/PTPRF/IMPA2/PNKP/ACP5/DUSP5/CAMK2G/INPP5D/PHPT1/DLG1/PTP4A2/PTPN3/UBASH3B/CTDSPL2/PTPRU/ILKAP/ENOPH1	30
GO:0019829	ATPase-coupled cation transmembrane transporter activity	5/2098	47/18367	0.635399217593565	0.958657500568488	ATP6V1F/ATP2B1/ATP6V1C2/ATP6V1B2/ATP6V0E1	5
GO:0046906	tetrapyrrole binding	16/2098	149/18367	0.642296036037109	0.966789305273711	CYBB/CYBA/JAK2/HMOX1/TBXAS1/CYB5A/TCN2/HEBP2/CYB5R4/BACH1/PGRMC2/CYC1/EIF2AK1/MMAB/MTR/CD320	16
GO:0042578	phosphoric ester hydrolase activity	40/2098	366/18367	0.642513855868791	0.966789305273711	PTPRC/SAMHD1/DUSP1/LRRK2/CCR1/FBP1/DUSP9/PGP/HMOX1/DUSP2/GPCPD1/PTPN6/PDIA3/PLCB2/NOTUM/PDE4A/CTDSPL/PPM1G/PTPN14/DUSP14/PLPP3/DUSP18/PTPRF/IMPA2/PNKP/ACP5/DUSP5/APEX1/CAMK2G/INPP5D/PHPT1/DLG1/PTP4A2/SMPDL3A/PTPN3/UBASH3B/CTDSPL2/PTPRU/ILKAP/ENOPH1	40
GO:0015291	secondary active transmembrane transporter activity	26/2098	240/18367	0.643921947350816	0.967609253324751	SLC11A1/SLC8A1/SLC16A3/SLC38A1/SLC26A2/SLC25A5/SLC25A3/SLC15A3/SLC6A6/SLC22A11/SLC25A1/SLC6A4/SLC13A4/SLC1A5/SLC16A12/SLC25A4/SLC16A1/SLC19A1/SLC20A1/SLC9A1/SLC13A3/SLC7A6/SLC25A6/SLC3A2/SLC1A3/SLC10A3	26
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4/2098	38/18367	0.644839684444339	0.967691146267877	RPS3/SIAH2/SIAH1/PARK7	4
GO:0043175	RNA polymerase core enzyme binding	6/2098	57/18367	0.64625729590316	0.968521963512623	RTF1/SMYD2/BRD4/ZNF326/AGO2/URI1	6
GO:0004843	thiol-dependent deubiquitinase	12/2098	113/18367	0.650032987500059	0.972879811732398	TNFAIP3/USP1/USP48/USP15/USP10/USP27X/PSMD14/USP14/USP3/USP22/DESI2/BRCC3	12
GO:0070888	E-box binding	5/2098	48/18367	0.654258118825773	0.976319899641134	ASCL2/GATA3/BHLHE40/BHLHE41/PPARG	5
GO:0000339	RNA cap binding	2/2098	19/18367	0.655815240347702	0.976319899641134	NCBP3/AGO2	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/2098	19/18367	0.655815240347702	0.976319899641134	GALNT11/GALNT18	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/2098	19/18367	0.655815240347702	0.976319899641134	SLC29A1/SLC6A4	2
GO:0004033	aldo-keto reductase (NADP) activity	3/2098	29/18367	0.659216582826243	0.978783826951283	AKR7A2/KCNAB2/AKR1B1	3
GO:0005231	excitatory extracellular ligand-gated ion channel activity	3/2098	29/18367	0.659216582826243	0.978783826951283	P2RX7/CHRNB1/CHRNA5	3
GO:0101005	deubiquitinase activity	12/2098	114/18367	0.662214698999154	0.981934758701127	TNFAIP3/USP1/USP48/USP15/USP10/USP27X/PSMD14/USP14/USP3/USP22/DESI2/BRCC3	12
GO:0050997	quaternary ammonium group binding	4/2098	39/18367	0.665440954414951	0.985415204622405	APOC1/DHTKD1/VDAC1/PITPNB	4
GO:0008080	N-acetyltransferase activity	7/2098	68/18367	0.671751990983714	0.992147360736171	SAT1/HAT1/BRCA2/ESCO2/USP22/SAT2/NAT14	7
GO:0005253	anion channel activity	9/2098	87/18367	0.674150693537612	0.992147360736171	FXYD3/CLDN4/LRRC8C/CLIC1/VDAC1/TTYH3/GABRE/BEST1/VDAC3	9
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6/2098	59/18367	0.679691472144565	0.992147360736171	ISG20/FEN1/APEX1/MGME1/EXO1/TOE1	6
GO:0030971	receptor tyrosine kinase binding	8/2098	78/18367	0.679832995852124	0.992147360736171	DOK2/PCNA/DOCK4/ITGAX/SH2B3/DAZAP2/PTPN14/EIF3A	8
GO:0004551	nucleotide diphosphatase activity	2/2098	20/18367	0.683759778199027	0.992147360736171	NUDT15/NUDT4	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/2098	20/18367	0.683759778199027	0.992147360736171	IL4I1/GLDC	2
GO:0031418	L-ascorbic acid binding	2/2098	20/18367	0.683759778199027	0.992147360736171	PLOD2/P3H1	2
GO:0061608	nuclear import signal receptor activity	2/2098	20/18367	0.683759778199027	0.992147360736171	KPNB1/IPO5	2
GO:0070300	phosphatidic acid binding	2/2098	20/18367	0.683759778199027	0.992147360736171	NRGN/COMMD1	2
GO:0015144	carbohydrate transmembrane transporter activity	4/2098	40/18367	0.685209128870875	0.992147360736171	SLC2A3/AQP9/SLC2A1/SLC2A6	4
GO:0008242	omega peptidase activity	13/2098	126/18367	0.693381621479898	0.992147360736171	GGH/TNFAIP3/USP1/USP48/USP15/USP10/USP27X/PSMD14/USP14/USP3/USP22/DESI2/BRCC3	13
GO:0008081	phosphoric diester hydrolase activity	9/2098	89/18367	0.700531235467975	0.992147360736171	CCR1/HMOX1/GPCPD1/PDIA3/PLCB2/NOTUM/PDE4A/APEX1/SMPDL3A	9
GO:0008097	5S rRNA binding	1/2098	10/18367	0.702772447235638	0.992147360736171	RPL5	1
GO:0008172	S-methyltransferase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	MTR	1
GO:0008239	dipeptidyl-peptidase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	DPP4	1
GO:0008526	phosphatidylinositol transfer activity	1/2098	10/18367	0.702772447235638	0.992147360736171	PITPNB	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/2098	10/18367	0.702772447235638	0.992147360736171	SLC35B4	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/2098	10/18367	0.702772447235638	0.992147360736171	SLC3A2	1
GO:0015232	heme transmembrane transporter activity	1/2098	10/18367	0.702772447235638	0.992147360736171	PGRMC2	1
GO:0015279	store-operated calcium channel activity	1/2098	10/18367	0.702772447235638	0.992147360736171	ORAI2	1
GO:0015643	toxic substance binding	1/2098	10/18367	0.702772447235638	0.992147360736171	ASS1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/2098	10/18367	0.702772447235638	0.992147360736171	DEGS1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/2098	10/18367	0.702772447235638	0.992147360736171	ADH5	1
GO:0019203	carbohydrate phosphatase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	FBP1	1
GO:0019531	oxalate transmembrane transporter activity	1/2098	10/18367	0.702772447235638	0.992147360736171	SLC26A2	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/2098	10/18367	0.702772447235638	0.992147360736171	HDAC2	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/2098	10/18367	0.702772447235638	0.992147360736171	HDAC2	1
GO:0033204	ribonuclease P RNA binding	1/2098	10/18367	0.702772447235638	0.992147360736171	POP7	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/2098	10/18367	0.702772447235638	0.992147360736171	PIK3AP1	1
GO:0045503	dynein light chain binding	1/2098	10/18367	0.702772447235638	0.992147360736171	GLUL	1
GO:0046030	inositol trisphosphate phosphatase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	INPP5D	1
GO:0050308	sugar-phosphatase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	FBP1	1
GO:0070567	cytidylyltransferase activity	1/2098	10/18367	0.702772447235638	0.992147360736171	CDS1	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/2098	10/18367	0.702772447235638	0.992147360736171	CASP1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/2098	10/18367	0.702772447235638	0.992147360736171	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/2098	10/18367	0.702772447235638	0.992147360736171	PITPNB	1
GO:0031210	phosphatidylcholine binding	3/2098	31/18367	0.703848941727292	0.992147360736171	APOC1/VDAC1/PITPNB	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/2098	41/18367	0.704138328055242	0.992147360736171	COL14A1/COL4A2/COL4A1/COL21A1	4
GO:0004527	exonuclease activity	8/2098	80/18367	0.707346835112142	0.992147360736171	ISG20/FEN1/RAD50/APEX1/MGME1/DDX1/EXO1/TOE1	8
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	2/2098	21/18367	0.709814614906699	0.992147360736171	LPCAT2/AGPAT2	2
GO:0005123	death receptor binding	2/2098	21/18367	0.709814614906699	0.992147360736171	MYD88/CASP8AP2	2
GO:0005243	gap junction channel activity	2/2098	21/18367	0.709814614906699	0.992147360736171	GJA1/GJA5	2
GO:0019200	carbohydrate kinase activity	2/2098	21/18367	0.709814614906699	0.992147360736171	HK3/HK2	2
GO:0051428	peptide hormone receptor binding	2/2098	21/18367	0.709814614906699	0.992147360736171	JAK2/GNAS	2
GO:1990381	ubiquitin-specific protease binding	2/2098	21/18367	0.709814614906699	0.992147360736171	PARK7/VCP	2
GO:0001222	transcription corepressor binding	3/2098	32/18367	0.72442585844122	0.993958130845244	STAT1/EZH2/SUZ12	3
GO:0001223	transcription coactivator binding	3/2098	32/18367	0.72442585844122	0.993958130845244	TFAM/RPL23/EPAS1	3
GO:0005416	amino acid:cation symporter activity	2/2098	22/18367	0.734046635582849	0.993958130845244	SLC38A1/SLC1A3	2
GO:0008106	alcohol dehydrogenase (NADP+) activity	2/2098	22/18367	0.734046635582849	0.993958130845244	AKR7A2/AKR1B1	2
GO:0015106	bicarbonate transmembrane transporter activity	2/2098	22/18367	0.734046635582849	0.993958130845244	SLC26A2/BEST1	2
GO:0015296	anion:cation symporter activity	2/2098	22/18367	0.734046635582849	0.993958130845244	SLC6A4/SLC13A4	2
GO:0015464	acetylcholine receptor activity	2/2098	22/18367	0.734046635582849	0.993958130845244	CHRNB1/CHRNA5	2
GO:0015645	fatty acid ligase activity	2/2098	22/18367	0.734046635582849	0.993958130845244	SLC27A2/ACSL4	2
GO:0016881	acid-amino acid ligase activity	2/2098	22/18367	0.734046635582849	0.993958130845244	PAICS/GCLM	2
GO:0120020	cholesterol transfer activity	2/2098	22/18367	0.734046635582849	0.993958130845244	TSPO/NPC2	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/2098	11/18367	0.736742235637863	0.993958130845244	BCL6	1
GO:0004143	diacylglycerol kinase activity	1/2098	11/18367	0.736742235637863	0.993958130845244	DGKD	1
GO:0005436	sodium:phosphate symporter activity	1/2098	11/18367	0.736742235637863	0.993958130845244	SLC20A1	1
GO:0015378	sodium:chloride symporter activity	1/2098	11/18367	0.736742235637863	0.993958130845244	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/2098	11/18367	0.736742235637863	0.993958130845244	SLC9A1	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/2098	11/18367	0.736742235637863	0.993958130845244	DDAH2	1
GO:0017128	phospholipid scramblase activity	1/2098	11/18367	0.736742235637863	0.993958130845244	PLSCR1	1
GO:0019107	myristoyltransferase activity	1/2098	11/18367	0.736742235637863	0.993958130845244	NMT1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/2098	11/18367	0.736742235637863	0.993958130845244	HSD17B1	1
GO:0032052	bile acid binding	1/2098	11/18367	0.736742235637863	0.993958130845244	VDR	1
GO:0035252	UDP-xylosyltransferase activity	1/2098	11/18367	0.736742235637863	0.993958130845244	GXYLT1	1
GO:0042285	xylosyltransferase activity	1/2098	11/18367	0.736742235637863	0.993958130845244	GXYLT1	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/2098	11/18367	0.736742235637863	0.993958130845244	SMYD2	1
GO:0070513	death domain binding	1/2098	11/18367	0.736742235637863	0.993958130845244	MCL1	1
GO:0097157	pre-mRNA intronic binding	1/2098	11/18367	0.736742235637863	0.993958130845244	PRPF8	1
GO:0140161	monocarboxylate:sodium symporter activity	1/2098	11/18367	0.736742235637863	0.993958130845244	SLC10A3	1
GO:1901474	azole transmembrane transporter activity	1/2098	11/18367	0.736742235637863	0.993958130845244	SLC19A3	1
GO:1990459	transferrin receptor binding	1/2098	11/18367	0.736742235637863	0.993958130845244	SNX4	1
GO:0051213	dioxygenase activity	9/2098	92/18367	0.737476524377388	0.993958130845244	ALOX5AP/ALOX5/P4HB/ASPH/ADI1/CDO1/PLOD2/KDM6B/P3H1	9
GO:1901618	organic hydroxy compound transmembrane transporter activity	5/2098	53/18367	0.738844422775342	0.993958130845244	SLC16A3/AQP9/SLC6A4/SLC16A1/SLC10A3	5
GO:0004180	carboxypeptidase activity	4/2098	43/18367	0.73948356924615	0.993958130845244	LAP3/VASH1/CTSZ/SCPEP1	4
GO:0030547	signaling receptor inhibitor activity	4/2098	43/18367	0.73948356924615	0.993958130845244	LILRB4/IL1RN/LRPAP1/NCAPG2	4
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	5/2098	54/18367	0.753793943640763	0.999984677299574	P4HB/ASPH/PLOD2/KDM6B/P3H1	5
GO:0019905	syntaxin binding	7/2098	74/18367	0.755345889265171	0.999984677299574	LRRK2/STXBP2/TMED9/SLC6A4/SYT7/STX10/STX6	7
GO:0008375	acetylglucosaminyltransferase activity	4/2098	44/18367	0.755913265401953	0.999984677299574	LFNG/EXTL2/MFNG/HEXB	4
GO:0008483	transaminase activity	2/2098	23/18367	0.75653210401792	0.999984677299574	OAT/GFPT1	2
GO:0015299	solute:proton antiporter activity	2/2098	23/18367	0.75653210401792	0.999984677299574	SLC11A1/SLC9A1	2
GO:0017025	TBP-class protein binding	2/2098	23/18367	0.75653210401792	0.999984677299574	HHEX/DRAP1	2
GO:0042171	lysophosphatidic acid acyltransferase activity	2/2098	23/18367	0.75653210401792	0.999984677299574	LPCAT2/AGPAT2	2
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	2/2098	23/18367	0.75653210401792	0.999984677299574	TNFAIP3/PRPF8	2
GO:0071617	lysophospholipid acyltransferase activity	2/2098	23/18367	0.75653210401792	0.999984677299574	LPCAT2/AGPAT2	2
GO:0120015	sterol transfer activity	2/2098	23/18367	0.75653210401792	0.999984677299574	TSPO/NPC2	2
GO:0016410	N-acyltransferase activity	9/2098	94/18367	0.760320313850538	0.999984677299574	TGM2/SAT1/HAT1/BRCA2/ESCO2/USP22/SAT2/NMT1/NAT14	9
GO:0015294	solute:cation symporter activity	10/2098	104/18367	0.763386128391373	0.999984677299574	SLC38A1/SLC25A3/SLC15A3/SLC6A6/SLC6A4/SLC13A4/SLC20A1/SLC13A3/SLC1A3/SLC10A3	10
GO:0008237	metallopeptidase activity	19/2098	190/18367	0.764519016250342	0.999984677299574	QPCT/LAP3/VASH1/MME/ADAM8/ENPEP/ADAMTS1/ADAMTS6/ANPEP/LTA4H/PSMD14/ADAMTS19/AFG3L2/DPEP2/UQCRC2/TFRC/PMPCB/MMP15/BRCC3	19
GO:0004526	ribonuclease P activity	1/2098	12/18367	0.76683129587058	0.999984677299574	POP7	1
GO:0005165	neurotrophin receptor binding	1/2098	12/18367	0.76683129587058	0.999984677299574	GRB2	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/2098	12/18367	0.76683129587058	0.999984677299574	SLC35B4	1
GO:0015166	polyol transmembrane transporter activity	1/2098	12/18367	0.76683129587058	0.999984677299574	AQP9	1
GO:0030955	potassium ion binding	1/2098	12/18367	0.76683129587058	0.999984677299574	DRG1	1
GO:0042166	acetylcholine binding	1/2098	12/18367	0.76683129587058	0.999984677299574	CHRNB1	1
GO:0043176	amine binding	1/2098	12/18367	0.76683129587058	0.999984677299574	SLC6A4	1
GO:0051378	serotonin binding	1/2098	12/18367	0.76683129587058	0.999984677299574	SLC6A4	1
GO:0089720	caspase binding	1/2098	12/18367	0.76683129587058	0.999984677299574	CARD16	1
GO:0008083	growth factor activity	16/2098	162/18367	0.767734006143226	0.999984677299574	TIMP1/GMFG/TYMP/TGFB1/EFEMP1/VEGFA/GRN/BMP7/HBEGF/MANF/NENF/CSH1/MDK/PTN/PDGFA/CD320	16
GO:0015293	symporter activity	14/2098	144/18367	0.777042728208874	0.999984677299574	SLC16A3/SLC38A1/SLC25A3/SLC15A3/SLC6A6/SLC6A4/SLC13A4/SLC1A5/SLC16A12/SLC16A1/SLC20A1/SLC13A3/SLC1A3/SLC10A3	14
GO:0000030	mannosyltransferase activity	2/2098	24/18367	0.77735364957173	0.999984677299574	TMTC3/ALG8	2
GO:0003707	steroid hormone receptor activity	2/2098	24/18367	0.77735364957173	0.999984677299574	ABHD2/PGRMC2	2
GO:0015295	solute:proton symporter activity	2/2098	24/18367	0.77735364957173	0.999984677299574	SLC25A3/SLC15A3	2
GO:0043495	protein-membrane adaptor activity	2/2098	24/18367	0.77735364957173	0.999984677299574	SYNE2/CIB1	2
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	2/2098	24/18367	0.77735364957173	0.999984677299574	PYCARD/BMP7	2
GO:0120014	phospholipid transfer activity	2/2098	24/18367	0.77735364957173	0.999984677299574	TRIAP1/PITPNB	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	12/2098	125/18367	0.779380630617224	0.999984677299574	APOBEC3A/HINT1/TGM2/CDA/DDAH2/HINT2/APOBEC3G/APOBEC3C/HDAC2/GCH1/NIT2/AMPD3	12
GO:0019783	ubiquitin-like protein-specific protease activity	12/2098	125/18367	0.779380630617224	0.999984677299574	TNFAIP3/USP1/USP48/USP15/USP10/USP27X/PSMD14/USP14/USP3/USP22/DESI2/BRCC3	12
GO:0002161	aminoacyl-tRNA editing activity	1/2098	13/18367	0.793482777279652	0.999984677299574	IARS2	1
GO:0004535	poly(A)-specific ribonuclease activity	1/2098	13/18367	0.793482777279652	0.999984677299574	TOE1	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/2098	13/18367	0.793482777279652	0.999984677299574	PPP1R14B	1
GO:0008195	phosphatidate phosphatase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	PLPP3	1
GO:0008417	fucosyltransferase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	FUT8	1
GO:0008494	translation activator activity	1/2098	13/18367	0.793482777279652	0.999984677299574	PABPC1	1
GO:0015250	water channel activity	1/2098	13/18367	0.793482777279652	0.999984677299574	AQP9	1
GO:0015271	outward rectifier potassium channel activity	1/2098	13/18367	0.793482777279652	0.999984677299574	KCNQ1	1
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	1/2098	13/18367	0.793482777279652	0.999984677299574	SLC10A3	1
GO:0015385	sodium:proton antiporter activity	1/2098	13/18367	0.793482777279652	0.999984677299574	SLC9A1	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	TRMT1	1
GO:0016594	glycine binding	1/2098	13/18367	0.793482777279652	0.999984677299574	GLDC	1
GO:0022851	GABA-gated chloride ion channel activity	1/2098	13/18367	0.793482777279652	0.999984677299574	GABRE	1
GO:0032036	myosin heavy chain binding	1/2098	13/18367	0.793482777279652	0.999984677299574	CORO1A	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	INPP5D	1
GO:0039706	co-receptor binding	1/2098	13/18367	0.793482777279652	0.999984677299574	LRRK2	1
GO:0045159	myosin II binding	1/2098	13/18367	0.793482777279652	0.999984677299574	TRIOBP	1
GO:0045504	dynein heavy chain binding	1/2098	13/18367	0.793482777279652	0.999984677299574	DYNC1LI2	1
GO:0052650	NADP-retinol dehydrogenase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	AKR1B1	1
GO:0061783	peptidoglycan muralytic activity	1/2098	13/18367	0.793482777279652	0.999984677299574	LYZ	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/2098	13/18367	0.793482777279652	0.999984677299574	INPP5D	1
GO:0005484	SNAP receptor activity	3/2098	36/18367	0.795652101714996	0.999984677299574	STX11/STX10/STX6	3
GO:0008266	poly(U) RNA binding	2/2098	25/18367	0.796597819518578	0.999984677299574	PABPC1/MSI2	2
GO:0035254	glutamate receptor binding	4/2098	47/18367	0.80039208797276	0.999984677299574	HOMER3/GNAS/FUS/HOMER1	4
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	4/2098	47/18367	0.80039208797276	0.999984677299574	ADRB1/GABRE/CHRNB1/CHRNA5	4
GO:0008276	protein methyltransferase activity	8/2098	88/18367	0.801371544911843	0.999984677299574	EZH2/SUZ12/SMYD2/ICMT/KMT5A/LCMT1/NTMT1/FBL	8
GO:0030546	signaling receptor activator activity	51/2098	495/18367	0.805466197940167	0.999984677299574	TIMP1/CCL3L3/GMFG/CCL3/TYMP/TNFSF13B/TNFSF10/CCL4/TGFB1/EFEMP1/HMGB1/SECTM1/SPP1/RETN/VEGFA/FBN1/TNF/HMGB2/METRNL/CXCL16/IL1B/APP/NAMPT/IL1RN/GRN/CXCL10/GPNMB/LRPAP1/BMP7/LGALS3/DPP4/SEMA4A/TNFSF12/IL16/HAMP/VSTM1/SEMA6A/CMTM3/HBEGF/CXCL8/FAM3B/SEMA6D/CMTM8/MANF/NENF/CSH1/MDK/PTN/PDGFA/IL18/CD320	51
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	31/2098	310/18367	0.810483442593005	0.999984677299574	ZEB2/SPI1/SKIL/TFEC/NFE2L3/IFI16/CEBPB/IRF8/NR2F6/ELK3/PEG3/HHEX/BCL6/TRPS1/MXD1/JDP2/ASCL2/TFAP2A/GATA3/BHLHE40/BACH1/MXI1/JUN/ATF3/BHLHE41/SMAD5/TBX3/IRX2/E2F7/PPARG/TFAP2C	31
GO:0005109	frizzled binding	3/2098	37/18367	0.810849277525578	0.999984677299574	RNF43/SDCBP/ZNRF3	3
GO:0048018	receptor ligand activity	50/2098	487/18367	0.810904154267061	0.999984677299574	TIMP1/CCL3L3/GMFG/CCL3/TYMP/TNFSF13B/TNFSF10/CCL4/TGFB1/EFEMP1/HMGB1/SECTM1/SPP1/RETN/VEGFA/FBN1/TNF/HMGB2/METRNL/CXCL16/IL1B/NAMPT/IL1RN/GRN/CXCL10/GPNMB/LRPAP1/BMP7/LGALS3/DPP4/SEMA4A/TNFSF12/IL16/HAMP/VSTM1/SEMA6A/CMTM3/HBEGF/CXCL8/FAM3B/SEMA6D/CMTM8/MANF/NENF/CSH1/MDK/PTN/PDGFA/IL18/CD320	50
GO:0120013	lipid transfer activity	4/2098	48/18367	0.81367699425885	0.999984677299574	TSPO/NPC2/TRIAP1/PITPNB	4
GO:0004435	phosphatidylinositol phospholipase C activity	2/2098	26/18367	0.814353107073353	0.999984677299574	CCR1/PLCB2	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2/2098	26/18367	0.814353107073353	0.999984677299574	GLUL/ZDHHC12	2
GO:0019707	protein-cysteine S-acyltransferase activity	2/2098	26/18367	0.814353107073353	0.999984677299574	GLUL/ZDHHC12	2
GO:0097602	cullin family protein binding	2/2098	26/18367	0.814353107073353	0.999984677299574	ANAPC11/DDB1	2
GO:0099604	ligand-gated calcium channel activity	2/2098	26/18367	0.814353107073353	0.999984677299574	TRPM2/MCOLN3	2
GO:0004707	MAP kinase activity	1/2098	14/18367	0.817089246347283	0.999984677299574	MAPK14	1
GO:0005313	L-glutamate transmembrane transporter activity	1/2098	14/18367	0.817089246347283	0.999984677299574	SLC1A3	1
GO:0005451	monovalent cation:proton antiporter activity	1/2098	14/18367	0.817089246347283	0.999984677299574	SLC9A1	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/2098	14/18367	0.817089246347283	0.999984677299574	PPT1	1
GO:0015562	efflux transmembrane transporter activity	1/2098	14/18367	0.817089246347283	0.999984677299574	GJA1	1
GO:0070411	I-SMAD binding	1/2098	14/18367	0.817089246347283	0.999984677299574	SMAD5	1
GO:0098599	palmitoyl hydrolase activity	1/2098	14/18367	0.817089246347283	0.999984677299574	PPT1	1
GO:0000149	SNARE binding	10/2098	110/18367	0.820391188092454	0.999984677299574	TNFAIP2/LRRK2/STXBP2/STX11/TMED9/SLC6A4/SYT7/STX10/PICALM/STX6	10
GO:0005501	retinoid binding	3/2098	38/18367	0.825078671218256	0.999984677299574	RARA/NR2F2/FABP5	3
GO:0019840	isoprenoid binding	3/2098	38/18367	0.825078671218256	0.999984677299574	RARA/NR2F2/FABP5	3
GO:0001217	DNA-binding transcription repressor activity	31/2098	313/18367	0.826253731512178	0.999984677299574	ZEB2/SPI1/SKIL/TFEC/NFE2L3/IFI16/CEBPB/IRF8/NR2F6/ELK3/PEG3/HHEX/BCL6/TRPS1/MXD1/JDP2/ASCL2/TFAP2A/GATA3/BHLHE40/BACH1/MXI1/JUN/ATF3/BHLHE41/SMAD5/TBX3/IRX2/E2F7/PPARG/TFAP2C	31
GO:0001671	ATPase activator activity	2/2098	27/18367	0.830708378442439	0.999984677299574	DNAJC19/DNAJC1	2
GO:0035255	ionotropic glutamate receptor binding	2/2098	27/18367	0.830708378442439	0.999984677299574	GNAS/FUS	2
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/2098	15/18367	0.837998457983713	0.999984677299574	PDE4A	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/2098	15/18367	0.837998457983713	0.999984677299574	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/2098	15/18367	0.837998457983713	0.999984677299574	SLC22A11	1
GO:0015929	hexosaminidase activity	1/2098	15/18367	0.837998457983713	0.999984677299574	HEXB	1
GO:0016805	dipeptidase activity	1/2098	15/18367	0.837998457983713	0.999984677299574	DPEP2	1
GO:0017136	NAD-dependent histone deacetylase activity	1/2098	15/18367	0.837998457983713	0.999984677299574	HDAC2	1
GO:0030280	structural constituent of skin epidermis	1/2098	15/18367	0.837998457983713	0.999984677299574	KRT10	1
GO:0042043	neurexin family protein binding	1/2098	15/18367	0.837998457983713	0.999984677299574	SDCBP	1
GO:0042813	Wnt-activated receptor activity	1/2098	15/18367	0.837998457983713	0.999984677299574	LRP5	1
GO:0070742	C2H2 zinc finger domain binding	1/2098	15/18367	0.837998457983713	0.999984677299574	MBD2	1
GO:0004402	histone acetyltransferase activity	3/2098	39/18367	0.838381814285198	0.999984677299574	HAT1/BRCA2/USP22	3
GO:0008187	poly-pyrimidine tract binding	2/2098	28/18367	0.845751633536862	0.999984677299574	PABPC1/MSI2	2
GO:0005372	water transmembrane transporter activity	1/2098	16/18367	0.856518468617441	0.999984677299574	AQP9	1
GO:0010181	FMN binding	1/2098	16/18367	0.856518468617441	0.999984677299574	NDUFV1	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/2098	16/18367	0.856518468617441	0.999984677299574	SLC22A11	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/2098	16/18367	0.856518468617441	0.999984677299574	IL4I1	1
GO:0022821	potassium ion antiporter activity	1/2098	16/18367	0.856518468617441	0.999984677299574	SLC9A1	1
GO:0022841	potassium ion leak channel activity	1/2098	16/18367	0.856518468617441	0.999984677299574	KCNK6	1
GO:0034979	NAD-dependent protein deacetylase activity	1/2098	16/18367	0.856518468617441	0.999984677299574	HDAC2	1
GO:0036122	BMP binding	1/2098	16/18367	0.856518468617441	0.999984677299574	ENG	1
GO:0042577	lipid phosphatase activity	1/2098	16/18367	0.856518468617441	0.999984677299574	PLPP3	1
GO:0140327	flippase activity	1/2098	16/18367	0.856518468617441	0.999984677299574	TMEM30B	1
GO:0016874	ligase activity	15/2098	165/18367	0.858875662792256	0.999984677299574	SLC27A2/GLUL/ACSS1/PAICS/NAE1/LIG1/IARS2/ACSL4/GCLM/GMPS/ASS1/SAE1/SUCLG1/RIMKLB/ASNSD1	15
GO:0032452	histone demethylase activity	2/2098	29/18367	0.859569044700612	0.999984677299574	KDM1B/KDM6B	2
GO:0033612	receptor serine/threonine kinase binding	2/2098	29/18367	0.859569044700612	0.999984677299574	PYCARD/BMP7	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/2098	29/18367	0.859569044700612	0.999984677299574	PLEKHA5/SNX24	2
GO:0140457	protein demethylase activity	2/2098	29/18367	0.859569044700612	0.999984677299574	KDM1B/KDM6B	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3/2098	41/18367	0.862379870670323	0.999984677299574	HAT1/BRCA2/USP22	3
GO:0005254	chloride channel activity	6/2098	74/18367	0.863054843148319	0.999984677299574	FXYD3/CLDN4/CLIC1/TTYH3/GABRE/BEST1	6
GO:0005217	intracellular ligand-gated ion channel activity	2/2098	30/18367	0.872244226157398	0.999984677299574	TRPM2/MCOLN3	2
GO:0016417	S-acyltransferase activity	2/2098	30/18367	0.872244226157398	0.999984677299574	GLUL/ZDHHC12	2
GO:0017147	Wnt-protein binding	2/2098	30/18367	0.872244226157398	0.999984677299574	WLS/LRP5	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/2098	30/18367	0.872244226157398	0.999984677299574	HSD17B1/HSD17B11	2
GO:0070566	adenylyltransferase activity	2/2098	30/18367	0.872244226157398	0.999984677299574	OAS2/OAS1	2
GO:0005005	transmembrane-ephrin receptor activity	1/2098	17/18367	0.872922166118428	0.999984677299574	EPHB4	1
GO:0008525	phosphatidylcholine transporter activity	1/2098	17/18367	0.872922166118428	0.999984677299574	PITPNB	1
GO:0015108	chloride transmembrane transporter activity	1/2098	17/18367	0.872922166118428	0.999984677299574	SLC26A2	1
GO:0015377	cation:chloride symporter activity	1/2098	17/18367	0.872922166118428	0.999984677299574	SLC6A4	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/2098	17/18367	0.872922166118428	0.999984677299574	PPT1	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/2098	17/18367	0.872922166118428	0.999984677299574	FTH1	1
GO:0017081	chloride channel regulator activity	1/2098	17/18367	0.872922166118428	0.999984677299574	SGK1	1
GO:0031420	alkali metal ion binding	1/2098	17/18367	0.872922166118428	0.999984677299574	DRG1	1
GO:0042165	neurotransmitter binding	1/2098	17/18367	0.872922166118428	0.999984677299574	CHRNB1	1
GO:0043395	heparan sulfate proteoglycan binding	1/2098	17/18367	0.872922166118428	0.999984677299574	PTPRC	1
GO:0019894	kinesin binding	3/2098	42/18367	0.873160764055029	0.999984677299574	ACTB/PRC1/CLSTN1	3
GO:0008408	3'-5' exonuclease activity	4/2098	54/18367	0.878855895270232	0.999984677299574	ISG20/RAD50/APEX1/TOE1	4
GO:0020037	heme binding	12/2098	139/18367	0.882631228116343	0.999984677299574	CYBB/CYBA/JAK2/HMOX1/TBXAS1/CYB5A/HEBP2/CYB5R4/BACH1/PGRMC2/CYC1/EIF2AK1	12
GO:0018024	histone-lysine N-methyltransferase activity	3/2098	43/18367	0.883186553665694	0.999984677299574	EZH2/SMYD2/KMT5A	3
GO:0016411	acylglycerol O-acyltransferase activity	2/2098	31/18367	0.883857694049129	0.999984677299574	LPCAT2/AGPAT2	2
GO:0046527	glucosyltransferase activity	1/2098	18/18367	0.887451283038512	0.999984677299574	ALG8	1
GO:0046624	sphingolipid transporter activity	1/2098	18/18367	0.887451283038512	0.999984677299574	PITPNB	1
GO:0048038	quinone binding	1/2098	18/18367	0.887451283038512	0.999984677299574	VKORC1	1
GO:0050811	GABA receptor binding	1/2098	18/18367	0.887451283038512	0.999984677299574	GABARAP	1
GO:0099095	ligand-gated anion channel activity	1/2098	18/18367	0.887451283038512	0.999984677299574	GABRE	1
GO:0140597	protein carrier activity	1/2098	18/18367	0.887451283038512	0.999984677299574	HSPA8	1
GO:0042626	ATPase-coupled transmembrane transporter activity	9/2098	109/18367	0.887803256477339	0.999984677299574	TAP2/TAP1/SLC26A2/ATP6V1F/ATP2B1/ATP6V1C2/TAPBP/ATP6V1B2/ATP6V0E1	9
GO:0003730	mRNA 3'-UTR binding	18/2098	201/18367	0.89138867392605	0.999984677299574	ZFP36/ZFP36L2/CELF2/RPS7/FUS/CARHSP1/PABPC1/RPL5/ZFP36L1/HNRNPR/SERBP1/IGF2BP3/EXOSC8/HNRNPD/KHSRP/HNRNPA0/HNRNPA2B1/TIA1	18
GO:0051879	Hsp90 protein binding	3/2098	44/18367	0.892499233294749	0.999984677299574	GBP1/RPS3/KPNB1	3
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	3/2098	44/18367	0.892499233294749	0.999984677299574	GABRE/CHRNB1/CHRNA5	3
GO:0008378	galactosyltransferase activity	2/2098	32/18367	0.894486483089657	0.999984677299574	C1GALT1/C1GALT1C1	2
GO:0031624	ubiquitin conjugating enzyme binding	2/2098	32/18367	0.894486483089657	0.999984677299574	SIAH2/SIAH1	2
GO:0048019	receptor antagonist activity	2/2098	32/18367	0.894486483089657	0.999984677299574	IL1RN/LRPAP1	2
GO:0015103	inorganic anion transmembrane transporter activity	13/2098	152/18367	0.897518448545037	0.999984677299574	FXYD3/SLC26A2/CLDN4/LRRC8C/SLC22A11/SLC6A4/SLC13A4/CLIC1/VDAC1/TTYH3/GABRE/BEST1/VDAC3	13
GO:0004222	metalloendopeptidase activity	9/2098	111/18367	0.899547184452203	0.999984677299574	MME/ADAM8/ADAMTS1/ADAMTS6/ADAMTS19/AFG3L2/UQCRC2/PMPCB/MMP15	9
GO:0003746	translation elongation factor activity	1/2098	19/18367	0.90031995207689	0.999984677299574	TSFM	1
GO:0004890	GABA-A receptor activity	1/2098	19/18367	0.90031995207689	0.999984677299574	GABRE	1
GO:0004970	ionotropic glutamate receptor activity	1/2098	19/18367	0.90031995207689	0.999984677299574	PTK2B	1
GO:0005003	ephrin receptor activity	1/2098	19/18367	0.90031995207689	0.999984677299574	EPHB4	1
GO:0022840	leak channel activity	1/2098	19/18367	0.90031995207689	0.999984677299574	KCNK6	1
GO:0022842	narrow pore channel activity	1/2098	19/18367	0.90031995207689	0.999984677299574	KCNK6	1
GO:0035613	RNA stem-loop binding	1/2098	19/18367	0.90031995207689	0.999984677299574	MYH10	1
GO:0005548	phospholipid transporter activity	4/2098	57/18367	0.90329578832008	0.999984677299574	TRIAP1/PLSCR1/TMEM30B/PITPNB	4
GO:0004623	phospholipase A2 activity	2/2098	33/18367	0.904203891127046	0.999984677299574	PLA2G7/PRDX6	2
GO:0005251	delayed rectifier potassium channel activity	2/2098	33/18367	0.904203891127046	0.999984677299574	KCNQ1/KCNE3	2
GO:0016408	C-acyltransferase activity	1/2098	20/18367	0.911717855965198	0.999984677299574	ACAT2	1
GO:0030296	protein tyrosine kinase activator activity	1/2098	20/18367	0.911717855965198	0.999984677299574	CD24	1
GO:0031681	G-protein beta-subunit binding	1/2098	20/18367	0.911717855965198	0.999984677299574	GNG12	1
GO:0015020	glucuronosyltransferase activity	2/2098	34/18367	0.91307932741766	0.999984677299574	CHPF/B3GAT3	2
GO:0016229	steroid dehydrogenase activity	2/2098	34/18367	0.91307932741766	0.999984677299574	HSD17B1/HSD17B11	2
GO:0045505	dynein intermediate chain binding	2/2098	34/18367	0.91307932741766	0.999984677299574	DYNLL2/DYNLT1	2
GO:0016758	hexosyltransferase activity	17/2098	197/18367	0.916237803230452	0.999984677299574	TYMP/RPN2/AGL/GALNT11/LFNG/EXTL2/CHPF/MFNG/MTAP/FUT8/C1GALT1/TMTC3/C1GALT1C1/B3GAT3/HEXB/GALNT18/ALG8	17
GO:0004620	phospholipase activity	8/2098	104/18367	0.918769280910832	0.999984677299574	CCR1/HMOX1/PDIA3/PLCB2/PLA2G7/NOTUM/PRDX6/MGLL	8
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5/2098	71/18367	0.919850460168749	0.999984677299574	HINT1/TGM2/HINT2/HDAC2/NIT2	5
GO:0000175	3'-5'-exoribonuclease activity	2/2098	35/18367	0.921178244270237	0.999984677299574	ISG20/TOE1	2
GO:0008528	G protein-coupled peptide receptor activity	12/2098	147/18367	0.921397656452743	0.999984677299574	CXCR4/FPR1/FPR3/CCR1/CCR2/CCRL2/LGR5/CYSLTR1/CX3CR1/GPR84/LGR4/SIGMAR1	12
GO:0004407	histone deacetylase activity	1/2098	21/18367	0.921813018018123	0.999984677299574	HDAC2	1
GO:0008373	sialyltransferase activity	1/2098	21/18367	0.921813018018123	0.999984677299574	ST3GAL5	1
GO:0015125	bile acid transmembrane transporter activity	1/2098	21/18367	0.921813018018123	0.999984677299574	SLC10A3	1
GO:0015662	P-type ion transporter activity	1/2098	21/18367	0.921813018018123	0.999984677299574	ATP2B1	1
GO:0051010	microtubule plus-end binding	1/2098	21/18367	0.921813018018123	0.999984677299574	CLIP1	1
GO:0140358	P-type transmembrane transporter activity	1/2098	21/18367	0.921813018018123	0.999984677299574	ATP2B1	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	7/2098	94/18367	0.923191341324862	0.999984677299574	LYZ/AGL/HPSE/FUCA1/GANAB/GAA/HEXB	7
GO:0022824	transmitter-gated ion channel activity	4/2098	60/18367	0.92326664764779	0.999984677299574	PTK2B/GABRE/CHRNB1/CHRNA5	4
GO:0022835	transmitter-gated channel activity	4/2098	60/18367	0.92326664764779	0.999984677299574	PTK2B/GABRE/CHRNB1/CHRNA5	4
GO:0032934	sterol binding	4/2098	60/18367	0.92326664764779	0.999984677299574	TSPO/NPC2/GPR183/VDAC1	4
GO:0015248	sterol transporter activity	2/2098	36/18367	0.928562135008781	0.999984677299574	TSPO/NPC2	2
GO:0034212	peptide N-acetyltransferase activity	3/2098	49/18367	0.929761597800917	0.999984677299574	HAT1/BRCA2/USP22	3
GO:0005230	extracellular ligand-gated ion channel activity	5/2098	73/18367	0.93065441295737	0.999984677299574	PTK2B/P2RX7/GABRE/CHRNB1/CHRNA5	5
GO:0008649	rRNA methyltransferase activity	1/2098	22/18367	0.930754274324565	0.999984677299574	FBL	1
GO:0016917	GABA receptor activity	1/2098	22/18367	0.930754274324565	0.999984677299574	GABRE	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/2098	22/18367	0.930754274324565	0.999984677299574	VCAN	1
GO:0033558	protein deacetylase activity	1/2098	22/18367	0.930754274324565	0.999984677299574	HDAC2	1
GO:0140102	catalytic activity, acting on a rRNA	1/2098	22/18367	0.930754274324565	0.999984677299574	FBL	1
GO:0004175	endopeptidase activity	40/2098	430/18367	0.93326516309195	0.999984677299574	CTSS/PSMB9/PSMB8/PYCARD/CFD/CTSB/CTSL/CASP1/CTSH/CTSD/CTSZ/MME/DPP4/PDIA3/ADAM8/CTSV/TPP1/ADAMTS1/USP1/ADAMTS6/GPAA1/USP48/PSMB2/USP15/PSMB5/USP10/PSMB6/PSMB1/USP14/CAPNS1/ADAMTS19/AFG3L2/PSMB10/UQCRC2/PRSS12/PSMB7/PMPCB/MMP15/CAPN1/ADGRG6	40
GO:0016298	lipase activity	10/2098	129/18367	0.933731988607166	0.999984677299574	CCR1/HMOX1/PDIA3/PLCB2/PLA2G7/NOTUM/PRDX6/LIPA/ABHD2/MGLL	10
GO:0098960	postsynaptic neurotransmitter receptor activity	4/2098	62/18367	0.93443624398863	0.999984677299574	ADRB1/GABRE/CHRNB1/CHRNA5	4
GO:0016409	palmitoyltransferase activity	2/2098	37/18367	0.935288584007821	0.999984677299574	GLUL/ZDHHC12	2
GO:0030551	cyclic nucleotide binding	2/2098	37/18367	0.935288584007821	0.999984677299574	PDE4A/SLC19A1	2
GO:0015485	cholesterol binding	3/2098	50/18367	0.935614332396501	0.999984677299574	TSPO/NPC2/VDAC1	3
GO:0140359	ABC-type transporter activity	3/2098	50/18367	0.935614332396501	0.999984677299574	TAP2/TAP1/TAPBP	3
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/2098	23/18367	0.938673463883958	0.999984677299574	PDE4A	1
GO:0005212	structural constituent of eye lens	1/2098	23/18367	0.938673463883958	0.999984677299574	VIM	1
GO:0016849	phosphorus-oxygen lyase activity	1/2098	23/18367	0.938673463883958	0.999984677299574	RNASET2	1
GO:0030552	cAMP binding	1/2098	23/18367	0.938673463883958	0.999984677299574	PDE4A	1
GO:0047617	acyl-CoA hydrolase activity	1/2098	23/18367	0.938673463883958	0.999984677299574	PPT1	1
GO:0015081	sodium ion transmembrane transporter activity	12/2098	152/18367	0.939646832380502	0.999984677299574	SLC8A1/SLC38A1/SLC6A6/TRPM2/SLC6A4/SLC13A4/SLC20A1/SLC9A1/SLC13A3/SLC3A2/SLC1A3/SLC10A3	12
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	2/2098	38/18367	0.941411356940574	0.999984677299574	ISG20/TOE1	2
GO:0140303	intramembrane lipid transporter activity	2/2098	38/18367	0.941411356940574	0.999984677299574	PLSCR1/TMEM30B	2
GO:0001653	peptide receptor activity	12/2098	153/18367	0.942821623803901	0.999984677299574	CXCR4/FPR1/FPR3/CCR1/CCR2/CCRL2/LGR5/CYSLTR1/CX3CR1/GPR84/LGR4/SIGMAR1	12
GO:0004622	lysophospholipase activity	1/2098	24/18367	0.945687368854055	0.999984677299574	MGLL	1
GO:0015252	proton channel activity	1/2098	24/18367	0.945687368854055	0.999984677299574	HVCN1	1
GO:0005319	lipid transporter activity	12/2098	154/18367	0.945850583310253	0.999984677299574	TSPO/NPC2/CD36/SLC2A1/SLC27A2/TRIAP1/FABP5/APOL3/PLSCR1/TMEM30B/PITPNB/SLC10A3	12
GO:0017046	peptide hormone binding	3/2098	52/18367	0.945990532702157	0.999984677299574	SLC40A1/IGF1R/INSR	3
GO:0019825	oxygen binding	2/2098	39/18367	0.946980521408433	0.999984677299574	SOD2/PARK7	2
GO:0032451	demethylase activity	2/2098	39/18367	0.946980521408433	0.999984677299574	KDM1B/KDM6B	2
GO:0030594	neurotransmitter receptor activity	8/2098	111/18367	0.947371316073698	0.999984677299574	TSPO/PTK2B/HRH2/ADRB1/P2RY11/GABRE/CHRNB1/CHRNA5	8
GO:0005496	steroid binding	7/2098	100/18367	0.948118067981538	0.999984677299574	TSPO/NPC2/HSD17B1/GPR183/VDR/VDAC1/PGRMC2	7
GO:0003724	RNA helicase activity	5/2098	77/18367	0.948439064567165	0.999984677299574	DDX60L/DDX1/DDX58/DDX18/DDX3Y	5
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/2098	25/18367	0.9518994334097	0.999984677299574	PDE4A	1
GO:0005242	inward rectifier potassium channel activity	1/2098	25/18367	0.9518994334097	0.999984677299574	KCNK6	1
GO:0016289	CoA hydrolase activity	1/2098	25/18367	0.9518994334097	0.999984677299574	PPT1	1
GO:0004532	exoribonuclease activity	2/2098	40/18367	0.952042589839893	0.999984677299574	ISG20/TOE1	2
GO:0043014	alpha-tubulin binding	2/2098	40/18367	0.952042589839893	0.999984677299574	BEX4/EML4	2
GO:0005544	calcium-dependent phospholipid binding	3/2098	54/18367	0.954793179877966	0.999984677299574	ANXA5/SYT7/ANXA3	3
GO:0008374	O-acyltransferase activity	3/2098	54/18367	0.954793179877966	0.999984677299574	LPCAT2/AGPAT2/PRDX6	3
GO:0008186	ATP-dependent activity, acting on RNA	5/2098	79/18367	0.955681427007248	0.999984677299574	DDX60L/DDX1/DDX58/DDX18/DDX3Y	5
GO:0004806	triglyceride lipase activity	1/2098	26/18367	0.957401286463153	0.999984677299574	ABHD2	1
GO:0042923	neuropeptide binding	1/2098	26/18367	0.957401286463153	0.999984677299574	SORL1	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/2098	26/18367	0.957401286463153	0.999984677299574	SLC26A2	1
GO:0061659	ubiquitin-like protein ligase activity	27/2098	316/18367	0.96095254509343	0.999984677299574	TRIM22/RNF43/ANAPC11/UBE2C/RNF130/BIRC3/SIAH2/TRIM69/FBXO6/RNF149/CBX4/UBE2D1/TRIM24/TRIM38/DTX3L/SIAH1/FANCL/RNF8/HERC5/ZNF451/UHRF1/PRPF19/ZNRF3/HUWE1/HLTF/UBE4B/MYLIP	27
GO:0004190	aspartic-type endopeptidase activity	1/2098	27/18367	0.962274090617796	0.999984677299574	CTSD	1
GO:0008066	glutamate receptor activity	1/2098	27/18367	0.962274090617796	0.999984677299574	PTK2B	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/2098	27/18367	0.962274090617796	0.999984677299574	INPP5D	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/2098	27/18367	0.962274090617796	0.999984677299574	TMEM30B	1
GO:0016790	thiolester hydrolase activity	2/2098	43/18367	0.964601411262445	0.999984677299574	PNKD/PPT1	2
GO:0005506	iron ion binding	11/2098	151/18367	0.965350639263293	0.999984677299574	FTH1/FTL/ALOX5/TBXAS1/CALR/RRM2/ADI1/CDO1/ACP5/PLOD2/P3H1	11
GO:0070001	aspartic-type peptidase activity	1/2098	28/18367	0.966589737176349	0.999984677299574	CTSD	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/2098	28/18367	0.966589737176349	0.999984677299574	ANKRD9	1
GO:0004842	ubiquitin-protein transferase activity	38/2098	433/18367	0.969880088629123	0.999984677299574	TRIM22/UBE2L6/TNFAIP3/UBE2T/RNF43/ANAPC11/BRCA1/DTL/UBE2C/RNF130/BIRC3/KLHL42/RNF213/LMO7/BARD1/SIAH2/UBE2S/TRIM69/FBXO6/RNF149/UBE2D1/TRIM24/TRIM38/DTX3L/SIAH1/FANCL/RNF8/HERC5/UHRF1/TRIM28/PRPF19/AKTIP/ZNRF3/HUWE1/UBE2N/HLTF/UBE4B/MYLIP	38
GO:0004181	metallocarboxypeptidase activity	1/2098	29/18367	0.970411904764768	0.999984677299574	VASH1	1
GO:0005245	voltage-gated calcium channel activity	2/2098	45/18367	0.971146241981565	0.999984677299574	CATSPER1/ITGAV	2
GO:0016279	protein-lysine N-methyltransferase activity	3/2098	59/18367	0.97127510970859	0.999984677299574	EZH2/SMYD2/KMT5A	3
GO:0061630	ubiquitin protein ligase activity	25/2098	304/18367	0.972878406742235	0.999984677299574	TRIM22/RNF43/ANAPC11/UBE2C/RNF130/BIRC3/SIAH2/TRIM69/FBXO6/RNF149/UBE2D1/TRIM24/TRIM38/DTX3L/SIAH1/FANCL/RNF8/HERC5/UHRF1/PRPF19/ZNRF3/HUWE1/HLTF/UBE4B/MYLIP	25
GO:0016278	lysine N-methyltransferase activity	3/2098	60/18367	0.973801870869685	0.999984677299574	EZH2/SMYD2/KMT5A	3
GO:0019787	ubiquitin-like protein transferase activity	40/2098	458/18367	0.975090372195084	0.999984677299574	TRIM22/UBE2L6/TNFAIP3/UBE2T/RNF43/ANAPC11/BRCA1/DTL/UBE2C/RNF130/BIRC3/KLHL42/RNF213/LMO7/BARD1/SIAH2/UBE2S/TRIM69/FBXO6/RNF149/CBX4/UBE2D1/TRIM24/TRIM38/DTX3L/SIAH1/FANCL/RNF8/HERC5/ZNF451/UHRF1/TRIM28/PRPF19/AKTIP/ZNRF3/HUWE1/UBE2N/HLTF/UBE4B/MYLIP	40
GO:0015085	calcium ion transmembrane transporter activity	9/2098	135/18367	0.976922908727395	0.999984677299574	SLC8A1/ORAI2/ATP2B1/CATSPER1/TRPV2/TRPM2/MCOLN3/ITGAV/SLC3A2	9
GO:0052689	carboxylic ester hydrolase activity	10/2098	147/18367	0.977766258309676	0.999984677299574	AOAH/PLA2G7/NOTUM/PON2/IARS2/APMAP/PRDX6/LIPA/ABHD2/MGLL	10
GO:0099094	ligand-gated cation channel activity	7/2098	113/18367	0.979062487825585	0.999984677299574	PTK2B/KCNK6/P2RX7/TRPM2/MCOLN3/CHRNB1/CHRNA5	7
GO:0008175	tRNA methyltransferase activity	1/2098	32/18367	0.979450086506703	0.999984677299574	TRMT1	1
GO:0043178	alcohol binding	5/2098	89/18367	0.97979452029008	0.999984677299574	TSPO/NPC2/ADAP2/VDAC1/CDIPT	5
GO:0004993	G protein-coupled serotonin receptor activity	1/2098	34/18367	0.983884021103064	0.999984677299574	HRH2	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/2098	34/18367	0.983884021103064	0.999984677299574	INPP5D	1
GO:0099589	serotonin receptor activity	1/2098	34/18367	0.983884021103064	0.999984677299574	HRH2	1
GO:0008227	G protein-coupled amine receptor activity	2/2098	51/18367	0.984504504340708	0.999984677299574	HRH2/ADRB1	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	16/2098	222/18367	0.986285210813605	0.999984677299574	LPCAT2/TGM2/SAT1/GLUL/ZDHHC12/AGPAT2/HAT1/SPHK1/PRDX6/BRCA2/ESCO2/ACAT2/USP22/SAT2/NMT1/NAT14	16
GO:0008194	UDP-glycosyltransferase activity	9/2098	143/18367	0.986573183977769	0.999984677299574	GALNT11/LFNG/EXTL2/CHPF/MFNG/GXYLT1/B3GAT3/HEXB/GALNT18	9
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	10/2098	156/18367	0.987689192534293	0.999984677299574	DNMT1/COMT/EZH2/TRMT1/SMYD2/ICMT/COMTD1/KMT5A/LCMT1/FBL	10
GO:0016741	transferase activity, transferring one-carbon groups	16/2098	225/18367	0.988446897265634	0.999984677299574	TYMS/GCSH/DNMT1/COMT/EZH2/TRMT1/SUZ12/SMYD2/ICMT/COMTD1/KMT5A/SHMT1/LCMT1/NTMT1/FBL/MTR	16
GO:0008168	methyltransferase activity	15/2098	214/18367	0.988515010335311	0.999984677299574	TYMS/GCSH/DNMT1/COMT/EZH2/TRMT1/SUZ12/SMYD2/ICMT/COMTD1/KMT5A/LCMT1/NTMT1/FBL/MTR	15
GO:0071855	neuropeptide receptor binding	1/2098	37/18367	0.988808101345624	0.999984677299574	GNAS	1
GO:0008170	N-methyltransferase activity	5/2098	97/18367	0.989542135877866	0.999984677299574	EZH2/TRMT1/SMYD2/KMT5A/FBL	5
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/2098	38/18367	0.990089094437653	0.999984677299574	DRAP1	1
GO:0019213	deacetylase activity	1/2098	38/18367	0.990089094437653	0.999984677299574	HDAC2	1
GO:0016746	acyltransferase activity	18/2098	250/18367	0.990232100314875	0.999984677299574	LPCAT2/QPCT/TGM2/SAT1/GLUL/CIITA/ZDHHC12/AGPAT2/HAT1/SPHK1/PRDX6/BRCA2/ESCO2/ACAT2/USP22/SAT2/NMT1/NAT14	18
GO:0000049	tRNA binding	3/2098	72/18367	0.991582592403438	0.999984677299574	TRMT1/IARS2/EIF2AK4	3
GO:0022836	gated channel activity	26/2098	340/18367	0.991918445545364	0.999984677299574	CYBB/HVCN1/KCNAB2/CATSPER1/KCNQ1/PTK2B/TMC6/KCNK6/P2RX7/KCNMB1/KCNE3/TRPM2/CLIC1/MCOLN3/ITGAV/KCNN4/TMC5/VDAC1/TMEM150C/TTYH3/GABRE/BEST1/VDAC3/CHRNB1/CHRNA5/TMEM109	26
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/2098	40/18367	0.992228170075901	0.999984677299574	HMOX1	1
GO:0004812	aminoacyl-tRNA ligase activity	1/2098	41/18367	0.993117857377738	0.999984677299574	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/2098	41/18367	0.993117857377738	0.999984677299574	IARS2	1
GO:0140098	catalytic activity, acting on RNA	30/2098	386/18367	0.993222298724713	0.999984677299574	SAMHD1/POLR2L/ISG20/RNASE6/FEN1/RNASET2/POP7/TRMT1/IARS2/RNASEH2A/POLR2H/DDX60L/POLR3K/POLR2F/TSEN34/POLR2I/PRIM1/SND1/POLR2K/APEX1/DDX1/DDX58/AGO2/POLR2J3/DDX18/FBL/EXO1/TOE1/LACTB2/DDX3Y	30
GO:0005244	voltage-gated ion channel activity	13/2098	201/18367	0.993686674177625	0.999984677299574	CYBB/HVCN1/KCNAB2/CATSPER1/KCNQ1/PTK2B/KCNK6/KCNE3/CLIC1/ITGAV/VDAC1/VDAC3/TMEM109	13
GO:0022832	voltage-gated channel activity	13/2098	201/18367	0.993686674177625	0.999984677299574	CYBB/HVCN1/KCNAB2/CATSPER1/KCNQ1/PTK2B/KCNK6/KCNE3/CLIC1/ITGAV/VDAC1/VDAC3/TMEM109	13
GO:0005249	voltage-gated potassium channel activity	4/2098	90/18367	0.994074762204149	0.999984677299574	KCNAB2/KCNQ1/KCNK6/KCNE3	4
GO:0015276	ligand-gated ion channel activity	8/2098	143/18367	0.99440872089041	0.999984677299574	PTK2B/KCNK6/P2RX7/TRPM2/MCOLN3/GABRE/CHRNB1/CHRNA5	8
GO:0022834	ligand-gated channel activity	8/2098	143/18367	0.99440872089041	0.999984677299574	PTK2B/KCNK6/P2RX7/TRPM2/MCOLN3/GABRE/CHRNB1/CHRNA5	8
GO:0022843	voltage-gated cation channel activity	8/2098	143/18367	0.99440872089041	0.999984677299574	HVCN1/KCNAB2/CATSPER1/KCNQ1/PTK2B/KCNK6/KCNE3/ITGAV	8
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/2098	43/18367	0.994603462017039	0.999984677299574	SQLE	1
GO:0005262	calcium channel activity	6/2098	119/18367	0.99502331292844	0.999984677299574	ORAI2/CATSPER1/TRPV2/TRPM2/MCOLN3/ITGAV	6
GO:0140223	general transcription initiation factor activity	1/2098	45/18367	0.995768497999285	0.999984677299574	DRAP1	1
GO:0005267	potassium channel activity	6/2098	121/18367	0.99578344565903	0.999984677299574	KCNAB2/KCNQ1/KCNK6/KCNMB1/KCNE3/KCNN4	6
GO:0005272	sodium channel activity	1/2098	46/18367	0.996253035233075	0.999984677299574	TRPM2	1
GO:0008173	RNA methyltransferase activity	2/2098	65/18367	0.996504999499789	0.999984677299574	TRMT1/FBL	2
GO:0046873	metal ion transmembrane transporter activity	32/2098	430/18367	0.99779096199569	0.999984677299574	SLC11A1/SLC8A1/SLC38A1/SLC40A1/SLC25A37/TUSC3/ORAI2/KCNAB2/ATP2B1/CATSPER1/KCNQ1/KCNK6/TRPV2/SLC39A10/SLC39A1/KCNMB1/KCNE3/SLC6A6/TRPM2/SLC6A4/SLC13A4/MCOLN3/ITGAV/KCNN4/SLC20A1/SLC39A7/SLC9A1/SLC13A3/MRS2/SLC3A2/SLC1A3/SLC10A3	32
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	9/2098	170/18367	0.998142460501967	0.999984677299574	P4HB/HMOX1/TBXAS1/DEGS1/ASPH/SQLE/PLOD2/KDM6B/P3H1	9
GO:0005179	hormone activity	5/2098	122/18367	0.99883333456944	0.999984677299574	RETN/FBN1/METRNL/HAMP/CSH1	5
GO:0015267	channel activity	35/2098	480/18367	0.99910567778348	0.999984677299574	CYBB/AQP9/FXYD3/HVCN1/ORAI2/CLDN4/KCNAB2/CATSPER1/KCNQ1/LRRC8C/PTK2B/TMC6/KCNK6/TRPV2/P2RX7/GJA1/KCNMB1/KCNE3/GJA5/TRPM2/CLIC1/TOMM40/MCOLN3/ITGAV/KCNN4/TMC5/VDAC1/TMEM150C/TTYH3/GABRE/BEST1/VDAC3/CHRNB1/CHRNA5/TMEM109	35
GO:0022803	passive transmembrane transporter activity	35/2098	481/18367	0.999150999180228	0.999984677299574	CYBB/AQP9/FXYD3/HVCN1/ORAI2/CLDN4/KCNAB2/CATSPER1/KCNQ1/LRRC8C/PTK2B/TMC6/KCNK6/TRPV2/P2RX7/GJA1/KCNMB1/KCNE3/GJA5/TRPM2/CLIC1/TOMM40/MCOLN3/ITGAV/KCNN4/TMC5/VDAC1/TMEM150C/TTYH3/GABRE/BEST1/VDAC3/CHRNB1/CHRNA5/TMEM109	35
GO:0034987	immunoglobulin receptor binding	2/2098	79/18367	0.999241941805409	0.999984677299574	FLNA/FGR	2
GO:0015079	potassium ion transmembrane transporter activity	7/2098	155/18367	0.999254958187586	0.999984677299574	KCNAB2/KCNQ1/KCNK6/KCNMB1/KCNE3/KCNN4/SLC9A1	7
GO:0004252	serine-type endopeptidase activity	8/2098	174/18367	0.999529063832896	0.999984677299574	CTSS/CFD/CTSH/DPP4/ADAM8/CTSV/TPP1/PRSS12	8
GO:0004497	monooxygenase activity	3/2098	102/18367	0.999587778125647	0.999984677299574	HMOX1/TBXAS1/SQLE	3
GO:0008236	serine-type peptidase activity	9/2098	191/18367	0.999650209679436	0.999984677299574	CTSS/CFD/CTSH/DPP4/ADAM8/CTSV/TPP1/SCPEP1/PRSS12	9
GO:0005216	ion channel activity	29/2098	432/18367	0.999672336367708	0.999984677299574	FXYD3/HVCN1/ORAI2/CLDN4/KCNAB2/CATSPER1/KCNQ1/LRRC8C/PTK2B/TMC6/KCNK6/TRPV2/P2RX7/KCNMB1/KCNE3/TRPM2/CLIC1/MCOLN3/ITGAV/KCNN4/TMC5/VDAC1/TMEM150C/TTYH3/GABRE/BEST1/VDAC3/CHRNB1/CHRNA5	29
GO:0017171	serine hydrolase activity	9/2098	195/18367	0.99974825906736	0.999984677299574	CTSS/CFD/CTSH/DPP4/ADAM8/CTSV/TPP1/SCPEP1/PRSS12	9
GO:0140101	catalytic activity, acting on a tRNA	4/2098	124/18367	0.999770309077114	0.999984677299574	POP7/TRMT1/IARS2/TSEN34	4
GO:0005261	cation channel activity	17/2098	335/18367	0.999984677299574	0.999984677299574	HVCN1/ORAI2/KCNAB2/CATSPER1/KCNQ1/PTK2B/KCNK6/TRPV2/P2RX7/KCNMB1/KCNE3/TRPM2/MCOLN3/ITGAV/KCNN4/CHRNB1/CHRNA5	17