ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0005539	glycosaminoglycan binding	14/241	230/18367	2.22247886153391e-06	0.000872174308584561	CCDC80/FBN1/NRP2/APLP2/ADAMTS1/BMP7/APP/SOD3/GNS/EXTL2/PCOLCE2/TGFBR3/SERPINE2/HYAL2	14
GO:0005178	integrin binding	11/241	144/18367	3.18893714290516e-06	0.000872174308584561	FBN1/ITGB4/DST/UTRN/LAMB1/ITGAV/ITGB1/LAMA5/ITGB8/P4HB/PLPP3	11
GO:0097493	structural molecule activity conferring elasticity	4/241	11/18367	8.87546554920098e-06	0.00161829321847098	FBN1/FBN2/LAMC1/AHNAK	4
GO:0008201	heparin binding	11/241	166/18367	1.24789441198437e-05	0.00170649560838863	CCDC80/FBN1/NRP2/APLP2/ADAMTS1/BMP7/APP/SOD3/PCOLCE2/TGFBR3/SERPINE2	11
GO:0038024	cargo receptor activity	7/241	77/18367	6.76026007544091e-05	0.00739572452253235	LRP2/LRP1/LGALS3BP/SCARA3/FOLR1/OLR1/MIA3	7
GO:0005201	extracellular matrix structural constituent	10/241	172/18367	9.38967245254366e-05	0.0085602513859023	FBN1/FBN2/LAMC1/COL14A1/LAMB1/FRAS1/COL21A1/LAMA5/EFEMP1/VWA1	10
GO:1901681	sulfur compound binding	12/241	265/18367	0.000207650778894578	0.0149569969247369	CCDC80/FBN1/LRP1/NRP2/APLP2/ADAMTS1/BMP7/APP/SOD3/PCOLCE2/TGFBR3/SERPINE2	12
GO:0003779	actin binding	16/241	440/18367	0.000243330802412918	0.0149569969247369	SVIL/DST/UTRN/PPP1R9A/POF1B/PALLD/SLC6A4/IQGAP2/DAG1/ITGB1/VCL/SYNE2/P4HB/MACF1/SPTBN1/MYH10	16
GO:0050431	transforming growth factor beta binding	4/241	24/18367	0.000249892802313318	0.0149569969247369	ITGAV/TGFBR3/HYAL2/TSKU	4
GO:0008509	anion transmembrane transporter activity	13/241	314/18367	0.000273436872481479	0.0149569969247369	SLC26A2/SLC6A4/CLDN4/SLC35D1/SLC22A11/SLC46A1/SLC38A9/GABRE/GJA1/SLC52A3/SLC12A9/SLC19A1/SLC1A3	13
GO:0004867	serine-type endopeptidase inhibitor activity	7/241	98/18367	0.000308158455884704	0.0153238795789939	APLP2/SPINT1/APP/ITIH5/CPAMD8/SERPINH1/SERPINE2	7
GO:0015026	coreceptor activity	5/241	48/18367	0.000403313465384177	0.0183843721304287	LRP5/LRP1/ITGAV/ITGB1/TGFBR3	5
GO:0001968	fibronectin binding	4/241	28/18367	0.000462098017044807	0.0192977474930803	CCDC80/CTSL/ITGAV/ITGB1	4
GO:0019838	growth factor binding	8/241	141/18367	0.000553702333896516	0.0192977474930803	LRP2/ITGB4/NRP2/IL6ST/ITGAV/TGFBR3/HYAL2/TSKU	8
GO:0005542	folic acid binding	3/241	13/18367	0.000578956710741853	0.0192977474930803	FOLR1/SLC46A1/SLC19A1	3
GO:0031994	insulin-like growth factor I binding	3/241	13/18367	0.000578956710741853	0.0192977474930803	LRP2/ITGB4/ITGAV	3
GO:0051015	actin filament binding	10/241	217/18367	0.000608393474199268	0.0192977474930803	SVIL/UTRN/PPP1R9A/POF1B/SLC6A4/IQGAP2/SYNE2/MACF1/SPTBN1/MYH10	10
GO:0004866	endopeptidase inhibitor activity	9/241	180/18367	0.000635026425732076	0.0192977474930803	APLP2/SPINT1/APP/ITIH5/GAPDH/CPAMD8/SERPINH1/SERPINE2/CST3	9
GO:0090482	vitamin transmembrane transporter activity	4/241	31/18367	0.000688576693465943	0.0197656022834834	SLC19A3/SLC46A1/SLC52A3/SLC19A1	4
GO:0008514	organic anion transmembrane transporter activity	9/241	185/18367	0.000772417312684585	0.0197656022834834	SLC26A2/SLC35D1/SLC22A11/SLC46A1/SLC38A9/GJA1/SLC52A3/SLC19A1/SLC1A3	9
GO:0030165	PDZ domain binding	6/241	84/18367	0.000830249475338732	0.0197656022834834	ADRB1/ATP2B1/GJA1/KIDINS220/ATP2B4/TGFBR3	6
GO:0030414	peptidase inhibitor activity	9/241	187/18367	0.00083374822453228	0.0197656022834834	APLP2/SPINT1/APP/ITIH5/GAPDH/CPAMD8/SERPINH1/SERPINE2/CST3	9
GO:0008013	beta-catenin binding	6/241	85/18367	0.00088366312695803	0.0197656022834834	KANK1/VCL/GJA1/GLI3/CDH1/TBL1X	6
GO:0005041	low-density lipoprotein particle receptor activity	3/241	15/18367	0.000903363906923372	0.0197656022834834	LRP2/LRP1/OLR1	3
GO:0050998	nitric-oxide synthase binding	3/241	15/18367	0.000903363906923372	0.0197656022834834	SLC6A4/CALM1/ATP2B4	3
GO:0061134	peptidase regulator activity	10/241	230/18367	0.000950819140127836	0.0200037719096126	APLP2/SPINT1/APP/ITIH5/GAPDH/CPAMD8/SERPINH1/PCOLCE2/SERPINE2/CST3	10
GO:0098631	cell adhesion mediator activity	5/241	59/18367	0.00104915681861044	0.02110614567748	BCAM/PALLD/ITGB1/DSC2/DSG2	5
GO:0061135	endopeptidase regulator activity	9/241	194/18367	0.00108038771292402	0.02110614567748	APLP2/SPINT1/APP/ITIH5/GAPDH/CPAMD8/SERPINH1/SERPINE2/CST3	9
GO:0097718	disordered domain specific binding	4/241	36/18367	0.00122463115363649	0.0230990772772124	CALM1/GJA5/GAPDH/GJA1	4
GO:0030228	lipoprotein particle receptor activity	3/241	18/18367	0.00157368756245388	0.0286935698887424	LRP2/LRP1/OLR1	3
GO:0004177	aminopeptidase activity	4/241	40/18367	0.00182376615625814	0.0321806479830065	CTSV/DPP4/MMP15/ENPEP	4
GO:0002020	protease binding	7/241	135/18367	0.00205059249877033	0.032765453506439	LRP1/ADAMTSL4/ITGAV/ITGB1/DPP4/STIM1/CST3	7
GO:0043177	organic acid binding	7/241	135/18367	0.00205059249877033	0.032765453506439	NR2F2/P3H2/FOLR1/SLC46A1/GLDC/SLC19A1/SLC1A3	7
GO:0005518	collagen binding	5/241	69/18367	0.00211856770176211	0.032765453506439	COL14A1/CTSL/ITGB1/SERPINH1/PCOLCE2	5
GO:0003756	protein disulfide isomerase activity	3/241	20/18367	0.00215641010280037	0.032765453506439	PDIA5/P4HB/PDIA3	3
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	3/241	20/18367	0.00215641010280037	0.032765453506439	PDIA5/P4HB/PDIA3	3
GO:0019955	cytokine binding	7/241	139/18367	0.00241865405033706	0.035756858527956	NRP2/IL6ST/ITGAV/ITGB1/TGFBR3/HYAL2/TSKU	7
GO:0072349	modified amino acid transmembrane transporter activity	3/241	22/18367	0.0028573025119794	0.0411301177382297	SLC46A1/GJA1/SLC19A1	3
GO:0001618	virus receptor activity	5/241	76/18367	0.00323454716185004	0.0453665973726147	ITGAV/DAG1/ITGB1/DPP4/HYAL2	5
GO:0140272	exogenous protein binding	5/241	77/18367	0.00342288141760153	0.046807903385701	ITGAV/DAG1/ITGB1/DPP4/HYAL2	5
GO:0045296	cadherin binding	11/241	332/18367	0.0045634655764519	0.0608833090321754	LDHA/AHNAK/ITGB1/HSPA5/VCL/DOCK9/MACF1/SPTBN1/CDH1/PPFIBP1/SLK	11
GO:0005516	calmodulin binding	8/241	201/18367	0.00515037721483569	0.0657885811137481	ATP2B1/KCNN4/IQGAP2/UBR4/ATP2B4/SPTBN1/MYH10/DDX5	8
GO:0045499	chemorepellent activity	3/241	27/18367	0.00517168005098933	0.0657885811137481	SEMA6A/SEMA6D/DPP4	3
GO:0043236	laminin binding	3/241	28/18367	0.00573682989506268	0.0713192261954383	BCAM/DAG1/ITGB1	3
GO:0050840	extracellular matrix binding	4/241	56/18367	0.00622676095545898	0.0753617859735918	BCAM/ITGAV/DAG1/ITGB1	4
GO:0005520	insulin-like growth factor binding	3/241	29/18367	0.00633755421350132	0.0753617859735918	LRP2/ITGB4/ITGAV	3
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/241	30/18367	0.00697440260108033	0.080355760329939	SLC26A2/SLC46A1/SLC19A1	3
GO:0008172	S-methyltransferase activity	2/241	10/18367	0.00719823081566181	0.080355760329939	MTR/DNMT3A	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/241	10/18367	0.00719823081566181	0.080355760329939	SLC35D1/SLC35A4	2
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	5/241	94/18367	0.00795296776717793	0.0870054673729265	MANBA/NAGLU/MAN2A2/GANAB/HYAL2	5
GO:0031406	carboxylic acid binding	7/241	176/18367	0.00869917975694579	0.0900192323248089	NR2F2/P3H2/FOLR1/SLC46A1/GLDC/SLC19A1/SLC1A3	7
GO:0002162	dystroglycan binding	2/241	11/18367	0.0087221559656579	0.0900192323248089	DAG1/VCL	2
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/241	11/18367	0.0087221559656579	0.0900192323248089	DSC2/DSG2	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/241	12/18367	0.0103766475290011	0.0995794069888349	SLC35D1/SLC35A4	2
GO:0017154	semaphorin receptor activity	2/241	12/18367	0.0103766475290011	0.0995794069888349	NRP2/MET	2
GO:0017166	vinculin binding	2/241	12/18367	0.0103766475290011	0.0995794069888349	UTRN/DAG1	2
GO:0031543	peptidyl-proline dioxygenase activity	2/241	12/18367	0.0103766475290011	0.0995794069888349	P3H2/P4HB	2
GO:0042887	amide transmembrane transporter activity	3/241	35/18367	0.0107169598548209	0.101072017941156	SLC46A1/GJA1/SLC19A1	3
GO:0008238	exopeptidase activity	5/241	103/18367	0.011543226781792	0.107019407621021	CTSV/DPP4/MMP15/ENPEP/CPQ	5
GO:0015035	protein-disulfide reductase activity	3/241	37/18367	0.0124817359182772	0.113791825788294	PDIA5/P4HB/PDIA3	3
GO:0019842	vitamin binding	6/241	148/18367	0.0135052119380005	0.121104113607972	P3H2/FOLR1/SLC46A1/GLDC/MTR/SLC19A1	6
GO:0015103	inorganic anion transmembrane transporter activity	6/241	152/18367	0.0152278876716885	0.134349267038929	SLC26A2/SLC6A4/CLDN4/SLC22A11/GABRE/SLC12A9	6
GO:0015929	hexosaminidase activity	2/241	15/18367	0.0160872872949012	0.139678510322396	NAGLU/HYAL2	2
GO:0015036	disulfide oxidoreductase activity	3/241	42/18367	0.0175822901719206	0.150273636313134	PDIA5/P4HB/PDIA3	3
GO:0015923	mannosidase activity	2/241	16/18367	0.018228170377527	0.15339706456165	MANBA/MAN2A2	2
GO:0004197	cysteine-type endopeptidase activity	5/241	119/18367	0.0203841114585264	0.164409269911498	CTSL/CTSV/LGMN/USP25/PDIA3	5
GO:0008381	mechanosensitive ion channel activity	2/241	17/18367	0.020482037706393	0.164409269911498	TMEM150C/TMC5	2
GO:0015377	cation:chloride symporter activity	2/241	17/18367	0.020482037706393	0.164409269911498	SLC6A4/SLC12A9	2
GO:0046943	carboxylic acid transmembrane transporter activity	6/241	163/18367	0.0207390121094942	0.164409269911498	SLC26A2/SLC46A1/SLC38A9/SLC27A2/SLC19A1/SLC1A3	6
GO:0005342	organic acid transmembrane transporter activity	6/241	164/18367	0.0212989239034792	0.166435876788616	SLC26A2/SLC46A1/SLC38A9/SLC27A2/SLC19A1/SLC1A3	6
GO:0005044	scavenger receptor activity	3/241	47/18367	0.0236810813432146	0.182444387249836	LRP1/LGALS3BP/SCARA3	3
GO:0022853	active ion transmembrane transporter activity	8/241	267/18367	0.0250181019879526	0.190068080380695	SLC26A2/ATP2B1/SLC6A4/SLC22A11/ATP2B4/SLC12A9/SLC19A1/SLC1A3	8
GO:0098632	cell-cell adhesion mediator activity	3/241	49/18367	0.0264015302213691	0.197830644261492	PALLD/DSC2/DSG2	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3/241	50/18367	0.0278218431042714	0.200725965111806	SLC35D1/SLC35A4/SLC19A1	3
GO:0016500	protein-hormone receptor activity	2/241	20/18367	0.0278887995402144	0.200725965111806	LGR5/LGR4	2
GO:0030506	ankyrin binding	2/241	20/18367	0.0278887995402144	0.200725965111806	SPTBN1/CDH1	2
GO:0016860	intramolecular oxidoreductase activity	3/241	51/18367	0.0292821120603636	0.204479630451801	PDIA5/P4HB/PDIA3	3
GO:0005243	gap junction channel activity	2/241	21/18367	0.0305621871752656	0.204479630451801	GJA5/GJA1	2
GO:0015662	P-type ion transporter activity	2/241	21/18367	0.0305621871752656	0.204479630451801	ATP2B1/ATP2B4	2
GO:0051010	microtubule plus-end binding	2/241	21/18367	0.0305621871752656	0.204479630451801	DST/STIM1	2
GO:0140358	P-type transmembrane transporter activity	2/241	21/18367	0.0305621871752656	0.204479630451801	ATP2B1/ATP2B4	2
GO:1901682	sulfur compound transmembrane transporter activity	3/241	52/18367	0.0307822344598715	0.204479630451801	SLC26A2/SLC19A3/GJA1	3
GO:0044325	transmembrane transporter binding	5/241	133/18367	0.031027073724862	0.204479630451801	TCAF1/PPP1R9A/CALM1/AKAP9/HTT	5
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/241	53/18367	0.0323220881929068	0.210478360018095	SLC35D1/SLC35A4/SLC19A1	3
GO:0005537	mannose binding	2/241	22/18367	0.0333326756415942	0.212011320650605	MANBA/LMAN1	2
GO:0015296	anion:cation symporter activity	2/241	22/18367	0.0333326756415942	0.212011320650605	SLC6A4/SLC12A9	2
GO:0017134	fibroblast growth factor binding	2/241	23/18367	0.0361972792361109	0.222470918451153	ITGAV/TGFBR3	2
GO:0030215	semaphorin receptor binding	2/241	23/18367	0.0361972792361109	0.222470918451153	SEMA6A/SEMA6D	2
GO:0070412	R-SMAD binding	2/241	23/18367	0.0361972792361109	0.222470918451153	JUN/DDX5	2
GO:0003714	transcription corepressor activity	6/241	187/18367	0.0371125377601601	0.22556175727564	TLE4/SRSF2/RERE/TBL1X/SF1/DNMT3A	6
GO:0008022	protein C-terminus binding	6/241	189/18367	0.0387660752683445	0.228852622735752	BCAM/DST/PPP1R9A/PRRC2C/TBL1X/SREBF2	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/241	57/18367	0.0388757323016162	0.228852622735752	PDIA5/P4HB/PDIA3	3
GO:0033218	amide binding	10/241	400/18367	0.0389091296424587	0.228852622735752	LRP1/CTSV/FOLR1/SLC46A1/ITM2B/ENPEP/DHCR24/SLC19A1/PLEKHA8/CST3	10
GO:0015291	secondary active transmembrane transporter activity	7/241	240/18367	0.0394314675441225	0.229457582411011	SLC26A2/SLC6A4/SLC35D1/SLC22A11/SLC12A9/SLC19A1/SLC1A3	7
GO:0019199	transmembrane receptor protein kinase activity	5/241	143/18367	0.0404293640030901	0.232788022207266	NRP2/EPHB4/MET/EFEMP1/TGFBR3	5
GO:0016798	hydrolase activity, acting on glycosyl bonds	5/241	144/18367	0.0414547456708913	0.236205686270599	MANBA/NAGLU/MAN2A2/GANAB/HYAL2	5
GO:0005112	Notch binding	2/241	25/18367	0.0421971932284937	0.236585614408863	GALNT11/AAK1	2
GO:0036002	pre-mRNA binding	3/241	59/18367	0.042386453769778	0.236585614408863	SRSF2/SF1/DDX5	3
GO:0016758	hexosyltransferase activity	6/241	197/18367	0.0458457641847193	0.253309424333752	GALNT11/EXTL2/FUT8/TMTC3/RPN2/GCNT2	6
GO:1990841	promoter-specific chromatin binding	3/241	62/18367	0.0479397880737952	0.257776381397119	ISL1/DDX5/FOXC1	3
GO:0016405	CoA-ligase activity	2/241	27/18367	0.0485392454915965	0.257776381397119	SLC27A2/ACSS1	2
GO:0051393	alpha-actinin binding	2/241	27/18367	0.0485392454915965	0.257776381397119	PALLD/DAG1	2
GO:0070006	metalloaminopeptidase activity	2/241	27/18367	0.0485392454915965	0.257776381397119	MMP15/ENPEP	2
GO:0015301	anion:anion antiporter activity	2/241	29/18367	0.0552016786127645	0.29033959808829	SLC26A2/SLC19A1	2
GO:0097110	scaffold protein binding	3/241	67/18367	0.0579429380079342	0.299809595991283	NLGN4X/IL6ST/ATP2B4	3
GO:0017147	Wnt-protein binding	2/241	30/18367	0.0586464840421705	0.299809595991283	LRP5/WLS	2
GO:0022829	wide pore channel activity	2/241	30/18367	0.0586464840421705	0.299809595991283	GJA5/GJA1	2
GO:0015631	tubulin binding	9/241	375/18367	0.0598071292762864	0.30291203439008	DST/GAPDH/DAG1/DPYSL2/HOOK2/GJA1/MACF1/HTT/STIM1	9
GO:0016878	acid-thiol ligase activity	2/241	31/18367	0.0621636288762288	0.30912277268452	SLC27A2/ACSS1	2
GO:0042910	xenobiotic transmembrane transporter activity	2/241	31/18367	0.0621636288762288	0.30912277268452	SLC46A1/SLC19A1	2
GO:0048029	monosaccharide binding	3/241	71/18367	0.0665954170821895	0.32692211112122	P3H2/MANBA/LMAN1	3
GO:0030246	carbohydrate binding	7/241	271/18367	0.0669383481637599	0.32692211112122	P3H2/GALNT11/MANBA/OLR1/MAN2A2/GANAB/LMAN1	7
GO:0008235	metalloexopeptidase activity	3/241	72/18367	0.0688458819882015	0.330126842072624	MMP15/ENPEP/CPQ	3
GO:0019956	chemokine binding	2/241	33/18367	0.0694050947684676	0.330126842072624	ITGAV/ITGB1	2
GO:0140323	solute:anion antiporter activity	2/241	33/18367	0.0694050947684676	0.330126842072624	SLC26A2/SLC19A1	2
GO:0008376	acetylgalactosaminyltransferase activity	2/241	34/18367	0.0731246238417114	0.341873241379625	GALNT11/EXTL2	2
GO:0035198	miRNA binding	2/241	34/18367	0.0731246238417114	0.341873241379625	KCNQ1OT1/PUM1	2
GO:0004714	transmembrane receptor protein tyrosine kinase activity	4/241	124/18367	0.0806432559374855	0.368083920007324	NRP2/EPHB4/MET/EFEMP1	4
GO:0042805	actinin binding	2/241	36/18367	0.0807496716652264	0.368083920007324	PALLD/DAG1	2
GO:0043394	proteoglycan binding	2/241	36/18367	0.0807496716652264	0.368083920007324	LRP1/CTSL	2
GO:0046332	SMAD binding	3/241	79/18367	0.0855340379947345	0.386670403166279	JUN/TGFBR3/DDX5	3
GO:0022804	active transmembrane transporter activity	9/241	406/18367	0.0878481843150044	0.393876695248421	SLC26A2/ATP2B1/SLC6A4/SLC35D1/SLC22A11/ATP2B4/SLC12A9/SLC19A1/SLC1A3	9
GO:0001540	amyloid-beta binding	3/241	84/18367	0.0984018341072289	0.436751111497517	LRP1/ITM2B/CST3	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/241	41/18367	0.100794582620162	0.436751111497517	SLC27A2/ACSS1	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/241	41/18367	0.100794582620162	0.436751111497517	COL14A1/COL21A1	2
GO:0015085	calcium ion transmembrane transporter activity	4/241	135/18367	0.102150036416738	0.436751111497517	MCOLN3/ATP2B1/ITGAV/ATP2B4	4
GO:0042393	histone binding	6/241	244/18367	0.102853828340413	0.436751111497517	MPHOSPH8/CTSL/MORC4/TBL1X/PHC2/MLLT6	6
GO:0004713	protein tyrosine kinase activity	4/241	136/18367	0.104224690013639	0.436751111497517	NRP2/EPHB4/MET/EFEMP1	4
GO:0008307	structural constituent of muscle	2/241	42/18367	0.104955197242574	0.436751111497517	DAG1/KRT19	2
GO:0008234	cysteine-type peptidase activity	5/241	190/18367	0.105517727505862	0.436751111497517	CTSL/CTSV/LGMN/USP25/PDIA3	5
GO:0005246	calcium channel regulator activity	2/241	43/18367	0.10916170280882	0.436751111497517	CALM1/STIM1	2
GO:0016504	peptidase activator activity	2/241	43/18367	0.10916170280882	0.436751111497517	APP/PCOLCE2	2
GO:0048306	calcium-dependent protein binding	3/241	88/18367	0.109222733726713	0.436751111497517	CALM1/ATP2B4/DDX5	3
GO:0099106	ion channel regulator activity	4/241	139/18367	0.11056327168139	0.436751111497517	CALM1/AKAP9/ATP2B4/STIM1	4
GO:0015297	antiporter activity	3/241	89/18367	0.111997327036255	0.436751111497517	SLC26A2/SLC35D1/SLC19A1	3
GO:0008375	acetylglucosaminyltransferase activity	2/241	44/18367	0.11341219148113	0.436751111497517	EXTL2/GCNT2	2
GO:0046873	metal ion transmembrane transporter activity	9/241	430/18367	0.114152892407906	0.436751111497517	MCOLN3/ATP2B1/SLC39A10/SLC6A4/KCNN4/ITGAV/ATP2B4/SLC12A9/SLC1A3	9
GO:0061980	regulatory RNA binding	2/241	46/18367	0.12203769497043	0.436751111497517	KCNQ1OT1/PUM1	2
GO:0072341	modified amino acid binding	3/241	93/18367	0.123359291012898	0.436751111497517	FOLR1/SLC46A1/SLC19A1	3
GO:0016247	channel regulator activity	4/241	145/18367	0.123740270215378	0.436751111497517	CALM1/AKAP9/ATP2B4/STIM1	4
GO:0005522	profilin binding	1/241	10/18367	0.123759455725987	0.436751111497517	HTT	1
GO:0008239	dipeptidyl-peptidase activity	1/241	10/18367	0.123759455725987	0.436751111497517	DPP4	1
GO:0015232	heme transmembrane transporter activity	1/241	10/18367	0.123759455725987	0.436751111497517	SLC46A1	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/241	10/18367	0.123759455725987	0.436751111497517	MAN2A2	1
GO:0016595	glutamate binding	1/241	10/18367	0.123759455725987	0.436751111497517	SLC1A3	1
GO:0019531	oxalate transmembrane transporter activity	1/241	10/18367	0.123759455725987	0.436751111497517	SLC26A2	1
GO:0031419	cobalamin binding	1/241	10/18367	0.123759455725987	0.436751111497517	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/241	10/18367	0.123759455725987	0.436751111497517	SLC27A2	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/241	10/18367	0.123759455725987	0.436751111497517	SACM1L	1
GO:0035612	AP-2 adaptor complex binding	1/241	10/18367	0.123759455725987	0.436751111497517	AAK1	1
GO:0045294	alpha-catenin binding	1/241	10/18367	0.123759455725987	0.436751111497517	VCL	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/241	10/18367	0.123759455725987	0.436751111497517	PIP5K1B	1
GO:0070567	cytidylyltransferase activity	1/241	10/18367	0.123759455725987	0.436751111497517	CDS1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/241	10/18367	0.123759455725987	0.436751111497517	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/241	10/18367	0.123759455725987	0.436751111497517	PLEKHA8	1
GO:0019829	ATPase-coupled cation transmembrane transporter activity	2/241	47/18367	0.126409100020528	0.438558903289689	ATP2B1/ATP2B4	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/241	47/18367	0.126409100020528	0.438558903289689	ADRB1/GABRE	2
GO:0043021	ribonucleoprotein complex binding	4/241	149/18367	0.132879081115067	0.438558903289689	HSPA5/NEMF/RPN2/DDX5	4
GO:0019903	protein phosphatase binding	4/241	150/18367	0.135206278868414	0.438558903289689	PPP1R9A/KCNN4/MET/ATP2B4	4
GO:0008503	benzodiazepine receptor activity	1/241	11/18367	0.13526318570202	0.438558903289689	GABRE	1
GO:0015378	sodium:chloride symporter activity	1/241	11/18367	0.13526318570202	0.438558903289689	SLC6A4	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/241	11/18367	0.13526318570202	0.438558903289689	P4HB	1
GO:0019855	calcium channel inhibitor activity	1/241	11/18367	0.13526318570202	0.438558903289689	CALM1	1
GO:0035673	oligopeptide transmembrane transporter activity	1/241	11/18367	0.13526318570202	0.438558903289689	GJA1	1
GO:0047676	arachidonate-CoA ligase activity	1/241	11/18367	0.13526318570202	0.438558903289689	SLC27A2	1
GO:1901474	azole transmembrane transporter activity	1/241	11/18367	0.13526318570202	0.438558903289689	SLC19A3	1
GO:0016757	glycosyltransferase activity	6/241	270/18367	0.14531923832541	0.438558903289689	GALNT11/EXTL2/FUT8/TMTC3/RPN2/GCNT2	6
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/241	12/18367	0.146616507354113	0.438558903289689	APEX2	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/241	12/18367	0.146616507354113	0.438558903289689	TGFBR3	1
GO:0005095	GTPase inhibitor activity	1/241	12/18367	0.146616507354113	0.438558903289689	IQGAP2	1
GO:0005165	neurotrophin receptor binding	1/241	12/18367	0.146616507354113	0.438558903289689	EFNA5	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/241	12/18367	0.146616507354113	0.438558903289689	APEX2	1
GO:0015269	calcium-activated potassium channel activity	1/241	12/18367	0.146616507354113	0.438558903289689	KCNN4	1
GO:0034452	dynactin binding	1/241	12/18367	0.146616507354113	0.438558903289689	HTT	1
GO:0035256	G protein-coupled glutamate receptor binding	1/241	12/18367	0.146616507354113	0.438558903289689	CALM1	1
GO:0043176	amine binding	1/241	12/18367	0.146616507354113	0.438558903289689	SLC6A4	1
GO:0045295	gamma-catenin binding	1/241	12/18367	0.146616507354113	0.438558903289689	CDH1	1
GO:0051378	serotonin binding	1/241	12/18367	0.146616507354113	0.438558903289689	SLC6A4	1
GO:0008017	microtubule binding	6/241	271/18367	0.147093899989447	0.438558903289689	DST/GAPDH/DPYSL2/HOOK2/MACF1/STIM1	6
GO:0016597	amino acid binding	2/241	52/18367	0.148783996470502	0.438558903289689	GLDC/SLC1A3	2
GO:0015294	solute:cation symporter activity	3/241	104/18367	0.156572658681841	0.438558903289689	SLC6A4/SLC12A9/SLC1A3	3
GO:0008179	adenylate cyclase binding	1/241	13/18367	0.157821379145323	0.438558903289689	CALM1	1
GO:0008195	phosphatidate phosphatase activity	1/241	13/18367	0.157821379145323	0.438558903289689	PLPP3	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/241	13/18367	0.157821379145323	0.438558903289689	SLC26A2	1
GO:0008417	fucosyltransferase activity	1/241	13/18367	0.157821379145323	0.438558903289689	FUT8	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/241	13/18367	0.157821379145323	0.438558903289689	TARBP1	1
GO:0016594	glycine binding	1/241	13/18367	0.157821379145323	0.438558903289689	GLDC	1
GO:0016840	carbon-nitrogen lyase activity	1/241	13/18367	0.157821379145323	0.438558903289689	APMAP	1
GO:0022851	GABA-gated chloride ion channel activity	1/241	13/18367	0.157821379145323	0.438558903289689	GABRE	1
GO:0031404	chloride ion binding	1/241	13/18367	0.157821379145323	0.438558903289689	NLGN4X	1
GO:0031432	titin binding	1/241	13/18367	0.157821379145323	0.438558903289689	CALM1	1
GO:0042301	phosphate ion binding	1/241	13/18367	0.157821379145323	0.438558903289689	NCEH1	1
GO:0051011	microtubule minus-end binding	1/241	13/18367	0.157821379145323	0.438558903289689	MACF1	1
GO:0052650	NADP-retinol dehydrogenase activity	1/241	13/18367	0.157821379145323	0.438558903289689	RDH14	1
GO:0070700	BMP receptor binding	1/241	13/18367	0.157821379145323	0.438558903289689	BMP7	1
GO:0072542	protein phosphatase activator activity	1/241	13/18367	0.157821379145323	0.438558903289689	CALM1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	2/241	54/18367	0.157945345426085	0.438558903289689	P3H2/P4HB	2
GO:0005080	protein kinase C binding	2/241	55/18367	0.16256515438089	0.439049257810072	ITGAV/SRSF2	2
GO:0051087	chaperone binding	3/241	107/18367	0.166072380693455	0.439049257810072	LRP2/HSPA5/ERP29	3
GO:0051287	NAD binding	2/241	56/18367	0.167209103095161	0.439049257810072	LDHA/GAPDH	2
GO:0005313	L-glutamate transmembrane transporter activity	1/241	14/18367	0.168879734142925	0.439049257810072	SLC1A3	1
GO:0015373	anion:sodium symporter activity	1/241	14/18367	0.168879734142925	0.439049257810072	SLC6A4	1
GO:0015562	efflux transmembrane transporter activity	1/241	14/18367	0.168879734142925	0.439049257810072	GJA1	1
GO:0015926	glucosidase activity	1/241	14/18367	0.168879734142925	0.439049257810072	GANAB	1
GO:0043023	ribosomal large subunit binding	1/241	14/18367	0.168879734142925	0.439049257810072	NEMF	1
GO:0044548	S100 protein binding	1/241	14/18367	0.168879734142925	0.439049257810072	AHNAK	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/241	14/18367	0.168879734142925	0.439049257810072	P2RY6	1
GO:0071837	HMG box domain binding	1/241	14/18367	0.168879734142925	0.439049257810072	JUN	1
GO:0042626	ATPase-coupled transmembrane transporter activity	3/241	109/18367	0.172498138200569	0.439049257810072	SLC26A2/ATP2B1/ATP2B4	3
GO:0001846	opsonin binding	1/241	15/18367	0.179793480346355	0.439049257810072	ITGAV	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/241	15/18367	0.179793480346355	0.439049257810072	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/241	15/18367	0.179793480346355	0.439049257810072	MAN2A2	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/241	15/18367	0.179793480346355	0.439049257810072	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/241	15/18367	0.179793480346355	0.439049257810072	SLC22A11	1
GO:0010851	cyclase regulator activity	1/241	15/18367	0.179793480346355	0.439049257810072	CALM1	1
GO:0016805	dipeptidase activity	1/241	15/18367	0.179793480346355	0.439049257810072	CPQ	1
GO:0032794	GTPase activating protein binding	1/241	15/18367	0.179793480346355	0.439049257810072	CDH1	1
GO:0042043	neurexin family protein binding	1/241	15/18367	0.179793480346355	0.439049257810072	NLGN4X	1
GO:0042813	Wnt-activated receptor activity	1/241	15/18367	0.179793480346355	0.439049257810072	LRP5	1
GO:0048185	activin binding	1/241	15/18367	0.179793480346355	0.439049257810072	TGFBR3	1
GO:0051371	muscle alpha-actinin binding	1/241	15/18367	0.179793480346355	0.439049257810072	PALLD	1
GO:0070742	C2H2 zinc finger domain binding	1/241	15/18367	0.179793480346355	0.439049257810072	SRRM2	1
GO:0071933	Arp2/3 complex binding	1/241	15/18367	0.179793480346355	0.439049257810072	IQGAP2	1
GO:1904680	peptide transmembrane transporter activity	1/241	15/18367	0.179793480346355	0.439049257810072	GJA1	1
GO:0015267	channel activity	9/241	480/18367	0.181173575788147	0.440453093138295	MCOLN3/KCNN4/CLDN4/ITGAV/GJA5/TMEM150C/GABRE/GJA1/TMC5	9
GO:0022803	passive transmembrane transporter activity	9/241	481/18367	0.182668655478193	0.442102004296978	MCOLN3/KCNN4/CLDN4/ITGAV/GJA5/TMEM150C/GABRE/GJA1/TMC5	9
GO:0005283	amino acid:sodium symporter activity	1/241	16/18367	0.190564501010944	0.442102004296978	SLC1A3	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/241	16/18367	0.190564501010944	0.442102004296978	SLC1A3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/241	16/18367	0.190564501010944	0.442102004296978	SLC22A11	1
GO:0016208	AMP binding	1/241	16/18367	0.190564501010944	0.442102004296978	ACSS1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/241	16/18367	0.190564501010944	0.442102004296978	PIP5K1B	1
GO:0032183	SUMO binding	1/241	16/18367	0.190564501010944	0.442102004296978	USP25	1
GO:0035497	cAMP response element binding	1/241	16/18367	0.190564501010944	0.442102004296978	JUN	1
GO:0042577	lipid phosphatase activity	1/241	16/18367	0.190564501010944	0.442102004296978	PLPP3	1
GO:0005507	copper ion binding	2/241	61/18367	0.190742363828312	0.442102004296978	F5/SOD3	2
GO:0015179	L-amino acid transmembrane transporter activity	2/241	61/18367	0.190742363828312	0.442102004296978	SLC38A9/SLC1A3	2
GO:0098960	postsynaptic neurotransmitter receptor activity	2/241	62/18367	0.195502449686796	0.447371854744757	ADRB1/GABRE	2
GO:0005005	transmembrane-ephrin receptor activity	1/241	17/18367	0.201194654967478	0.447371854744757	EPHB4	1
GO:0005324	long-chain fatty acid transporter activity	1/241	17/18367	0.201194654967478	0.447371854744757	SLC27A2	1
GO:0008484	sulfuric ester hydrolase activity	1/241	17/18367	0.201194654967478	0.447371854744757	GNS	1
GO:0015108	chloride transmembrane transporter activity	1/241	17/18367	0.201194654967478	0.447371854744757	SLC26A2	1
GO:0015116	sulfate transmembrane transporter activity	1/241	17/18367	0.201194654967478	0.447371854744757	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/241	17/18367	0.201194654967478	0.447371854744757	SLC38A9	1
GO:0015278	calcium-release channel activity	1/241	17/18367	0.201194654967478	0.447371854744757	MCOLN3	1
GO:0034185	apolipoprotein binding	1/241	17/18367	0.201194654967478	0.447371854744757	LRP1	1
GO:0043395	heparan sulfate proteoglycan binding	1/241	17/18367	0.201194654967478	0.447371854744757	LRP1	1
GO:0004175	endopeptidase activity	8/241	430/18367	0.205143473335795	0.454305586699108	CTSL/ADAMTS1/CTSV/DPP4/MMP15/LGMN/USP25/PDIA3	8
GO:0000295	adenine nucleotide transmembrane transporter activity	1/241	18/18367	0.21168577693766	0.457676363576679	SLC19A1	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/241	18/18367	0.21168577693766	0.457676363576679	SACM1L	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/241	18/18367	0.21168577693766	0.457676363576679	SLC19A1	1
GO:0008301	DNA binding, bending	1/241	18/18367	0.21168577693766	0.457676363576679	FOXC1	1
GO:0046624	sphingolipid transporter activity	1/241	18/18367	0.21168577693766	0.457676363576679	PLEKHA8	1
GO:0099095	ligand-gated anion channel activity	1/241	18/18367	0.21168577693766	0.457676363576679	GABRE	1
GO:0043022	ribosome binding	2/241	66/18367	0.214679556158104	0.461808759625439	HSPA5/RPN2	2
GO:0051082	unfolded protein binding	3/241	122/18367	0.215803019753257	0.461808759625439	HSPA5/SERPINH1/LMAN1	3
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/241	19/18367	0.222039677845504	0.461808759625439	GALNT11	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/241	19/18367	0.222039677845504	0.461808759625439	TGFBR3	1
GO:0004890	GABA-A receptor activity	1/241	19/18367	0.222039677845504	0.461808759625439	GABRE	1
GO:0005003	ephrin receptor activity	1/241	19/18367	0.222039677845504	0.461808759625439	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/241	19/18367	0.222039677845504	0.461808759625439	SLC6A4	1
GO:0035613	RNA stem-loop binding	1/241	19/18367	0.222039677845504	0.461808759625439	MYH10	1
GO:0052742	phosphatidylinositol kinase activity	1/241	19/18367	0.222039677845504	0.461808759625439	PIP5K1B	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/241	19/18367	0.222039677845504	0.461808759625439	SACM1L	1
GO:0001972	retinoic acid binding	1/241	20/18367	0.232258145124729	0.467077960967745	NR2F2	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/241	20/18367	0.232258145124729	0.467077960967745	GLDC	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/241	20/18367	0.232258145124729	0.467077960967745	CDS1	1
GO:0019211	phosphatase activator activity	1/241	20/18367	0.232258145124729	0.467077960967745	CALM1	1
GO:0030296	protein tyrosine kinase activator activity	1/241	20/18367	0.232258145124729	0.467077960967745	EFNA5	1
GO:0031418	L-ascorbic acid binding	1/241	20/18367	0.232258145124729	0.467077960967745	P3H2	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/241	20/18367	0.232258145124729	0.467077960967745	GNAQ	1
GO:0031690	adrenergic receptor binding	1/241	20/18367	0.232258145124729	0.467077960967745	ADRB1	1
GO:0097001	ceramide binding	1/241	20/18367	0.232258145124729	0.467077960967745	PLEKHA8	1
GO:0008237	metallopeptidase activity	4/241	190/18367	0.239636798260477	0.472622635804506	ADAMTS1/MMP15/ENPEP/CPQ	4
GO:0031072	heat shock protein binding	3/241	129/18367	0.239996796933004	0.472622635804506	HSPA5/HTT/DNAJB14	3
GO:0001614	purinergic nucleotide receptor activity	1/241	21/18367	0.242342943022202	0.472622635804506	P2RY6	1
GO:0005385	zinc ion transmembrane transporter activity	1/241	21/18367	0.242342943022202	0.472622635804506	SLC39A10	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/241	21/18367	0.242342943022202	0.472622635804506	SLC19A1	1
GO:0016502	nucleotide receptor activity	1/241	21/18367	0.242342943022202	0.472622635804506	P2RY6	1
GO:0017124	SH3 domain binding	3/241	130/18367	0.243491110950737	0.472622635804506	LRP2/FUT8/GJA1	3
GO:0042277	peptide binding	6/241	321/18367	0.246783979723928	0.472622635804506	LRP1/CTSV/ITM2B/ENPEP/DHCR24/CST3	6
GO:0015370	solute:sodium symporter activity	2/241	73/18367	0.248593624244616	0.472622635804506	SLC6A4/SLC1A3	2
GO:0035064	methylated histone binding	2/241	73/18367	0.248593624244616	0.472622635804506	MPHOSPH8/MORC4	2
GO:0140034	methylation-dependent protein binding	2/241	73/18367	0.248593624244616	0.472622635804506	MPHOSPH8/MORC4	2
GO:0005416	amino acid:cation symporter activity	1/241	22/18367	0.252295812897469	0.472622635804506	SLC1A3	1
GO:0005540	hyaluronic acid binding	1/241	22/18367	0.252295812897469	0.472622635804506	HYAL2	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/241	22/18367	0.252295812897469	0.472622635804506	RDH14	1
GO:0015106	bicarbonate transmembrane transporter activity	1/241	22/18367	0.252295812897469	0.472622635804506	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/241	22/18367	0.252295812897469	0.472622635804506	SLC27A2	1
GO:0016917	GABA receptor activity	1/241	22/18367	0.252295812897469	0.472622635804506	GABRE	1
GO:0017075	syntaxin-1 binding	1/241	22/18367	0.252295812897469	0.472622635804506	SLC6A4	1
GO:0030742	GTP-dependent protein binding	1/241	22/18367	0.252295812897469	0.472622635804506	HPS6	1
GO:0070034	telomerase RNA binding	1/241	22/18367	0.252295812897469	0.472622635804506	NAF1	1
GO:0005254	chloride channel activity	2/241	74/18367	0.253458753234844	0.473180675834333	CLDN4/GABRE	2
GO:0019902	phosphatase binding	4/241	196/18367	0.256736268238621	0.477669179341923	PPP1R9A/KCNN4/MET/ATP2B4	4
GO:0005096	GTPase activator activity	8/241	462/18367	0.262032020858077	0.479527775968518	JUN/RGL3/ADRB1/SYDE2/IQGAP2/HACD3/DOCK9/GNAQ	8
GO:0004529	exodeoxyribonuclease activity	1/241	23/18367	0.26211847351844	0.479527775968518	APEX2	1
GO:0008143	poly(A) binding	1/241	23/18367	0.26211847351844	0.479527775968518	HNRNPDL	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/241	23/18367	0.26211847351844	0.479527775968518	APEX2	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/241	23/18367	0.26211847351844	0.479527775968518	FUT8	1
GO:0003724	RNA helicase activity	2/241	77/18367	0.26806386459205	0.487480340590941	DDX24/DDX5	2
GO:0000030	mannosyltransferase activity	1/241	24/18367	0.271812621353267	0.487480340590941	TMTC3	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/241	24/18367	0.271812621353267	0.487480340590941	GAPDH	1
GO:0043495	protein-membrane adaptor activity	1/241	24/18367	0.271812621353267	0.487480340590941	SYNE2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/241	24/18367	0.271812621353267	0.487480340590941	BMP7	1
GO:0120014	phospholipid transfer activity	1/241	24/18367	0.271812621353267	0.487480340590941	PLEKHA8	1
GO:0008186	ATP-dependent activity, acting on RNA	2/241	79/18367	0.277800074183517	0.493316737755066	DDX24/DDX5	2
GO:0019887	protein kinase regulator activity	4/241	204/18367	0.27989686227074	0.493316737755066	EFNA5/CALM1/KIDINS220/HYAL2	4
GO:0005160	transforming growth factor beta receptor binding	1/241	25/18367	0.281379930858465	0.493316737755066	TGFBR3	1
GO:0005227	calcium activated cation channel activity	1/241	25/18367	0.281379930858465	0.493316737755066	KCNN4	1
GO:0008266	poly(U) RNA binding	1/241	25/18367	0.281379930858465	0.493316737755066	MSI2	1
GO:0034237	protein kinase A regulatory subunit binding	1/241	25/18367	0.281379930858465	0.493316737755066	AKAP9	1
GO:0035035	histone acetyltransferase binding	1/241	25/18367	0.281379930858465	0.493316737755066	GLI3	1
GO:0070851	growth factor receptor binding	3/241	141/18367	0.282388769586924	0.493503696370759	IL6ST/APP/EFEMP1	3
GO:0016887	ATP hydrolysis activity	5/241	272/18367	0.286457868389992	0.499020554169827	ATP2B1/HSPA5/ATP2B4/DDX24/DDX5	5
GO:0022836	gated channel activity	6/241	340/18367	0.288965998372221	0.500250515583472	MCOLN3/KCNN4/ITGAV/TMEM150C/GABRE/TMC5	6
GO:0008194	UDP-glycosyltransferase activity	3/241	143/18367	0.28952853859046	0.500250515583472	GALNT11/EXTL2/GCNT2	3
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/241	26/18367	0.290822054763335	0.500250515583472	SLC26A2	1
GO:0099604	ligand-gated calcium channel activity	1/241	26/18367	0.290822054763335	0.500250515583472	MCOLN3	1
GO:0015293	symporter activity	3/241	144/18367	0.293103634252172	0.500494814689134	SLC6A4/SLC12A9/SLC1A3	3
GO:0015215	nucleotide transmembrane transporter activity	1/241	27/18367	0.300140624350709	0.500494814689134	SLC19A1	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/241	27/18367	0.300140624350709	0.500494814689134	SACM1L	1
GO:0043425	bHLH transcription factor binding	1/241	27/18367	0.300140624350709	0.500494814689134	ISL1	1
GO:0048027	mRNA 5'-UTR binding	1/241	27/18367	0.300140624350709	0.500494814689134	MYH10	1
GO:0051959	dynein light intermediate chain binding	1/241	27/18367	0.300140624350709	0.500494814689134	HOOK2	1
GO:0015171	amino acid transmembrane transporter activity	2/241	84/18367	0.302091863877726	0.500494814689134	SLC38A9/SLC1A3	2
GO:0052689	carboxylic ester hydrolase activity	3/241	147/18367	0.303845555161602	0.500494814689134	NCEH1/PGAP1/APMAP	3
GO:0008168	methyltransferase activity	4/241	214/18367	0.309277039553233	0.500494814689134	METTL7A/MTR/TARBP1/DNMT3A	4
GO:0004629	phospholipase C activity	1/241	28/18367	0.309337249734105	0.500494814689134	PDIA3	1
GO:0008187	poly-pyrimidine tract binding	1/241	28/18367	0.309337249734105	0.500494814689134	MSI2	1
GO:0015101	organic cation transmembrane transporter activity	1/241	28/18367	0.309337249734105	0.500494814689134	SLC19A3	1
GO:0046875	ephrin receptor binding	1/241	28/18367	0.309337249734105	0.500494814689134	EFNA5	1
GO:0050681	androgen receptor binding	1/241	28/18367	0.309337249734105	0.500494814689134	DDX5	1
GO:0051861	glycolipid binding	1/241	28/18367	0.309337249734105	0.500494814689134	PLEKHA8	1
GO:0070325	lipoprotein particle receptor binding	1/241	28/18367	0.309337249734105	0.500494814689134	LRP1	1
GO:0030695	GTPase regulator activity	8/241	488/18367	0.311355635089599	0.500494814689134	JUN/RGL3/ADRB1/SYDE2/IQGAP2/HACD3/DOCK9/GNAQ	8
GO:0060589	nucleoside-triphosphatase regulator activity	8/241	488/18367	0.311355635089599	0.500494814689134	JUN/RGL3/ADRB1/SYDE2/IQGAP2/HACD3/DOCK9/GNAQ	8
GO:0003712	transcription coregulator activity	8/241	489/18367	0.313293743931229	0.500494814689134	TLE4/SRSF2/WWC1/RERE/TBL1X/SF1/DNMT3A/HYAL2	8
GO:0003727	single-stranded RNA binding	2/241	87/18367	0.316604059089991	0.500494814689134	HNRNPDL/MSI2	2
GO:0005253	anion channel activity	2/241	87/18367	0.316604059089991	0.500494814689134	CLDN4/GABRE	2
GO:0004033	aldo-keto reductase (NADP) activity	1/241	29/18367	0.318413520131296	0.500494814689134	RDH14	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/241	29/18367	0.318413520131296	0.500494814689134	DHCR24	1
GO:0032452	histone demethylase activity	1/241	29/18367	0.318413520131296	0.500494814689134	JARID2	1
GO:0033612	receptor serine/threonine kinase binding	1/241	29/18367	0.318413520131296	0.500494814689134	BMP7	1
GO:0046625	sphingolipid binding	1/241	29/18367	0.318413520131296	0.500494814689134	PLEKHA8	1
GO:0051787	misfolded protein binding	1/241	29/18367	0.318413520131296	0.500494814689134	HSPA5	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/241	29/18367	0.318413520131296	0.500494814689134	PLEKHA8	1
GO:0070717	poly-purine tract binding	1/241	29/18367	0.318413520131296	0.500494814689134	HNRNPDL	1
GO:0140457	protein demethylase activity	1/241	29/18367	0.318413520131296	0.500494814689134	JARID2	1
GO:0030546	signaling receptor activator activity	8/241	495/18367	0.324973388263852	0.505852935766949	FBN1/EFNA5/SEMA6A/SEMA6D/BMP7/APP/DPP4/EFEMP1	8
GO:0008081	phosphoric diester hydrolase activity	2/241	89/18367	0.326241353106016	0.505852935766949	APEX2/PDIA3	2
GO:0019888	protein phosphatase regulator activity	2/241	89/18367	0.326241353106016	0.505852935766949	CALM1/RCAN1	2
GO:0051117	ATPase binding	2/241	89/18367	0.326241353106016	0.505852935766949	USP25/SVIP	2
GO:0005217	intracellular ligand-gated ion channel activity	1/241	30/18367	0.327371004134369	0.505852935766949	MCOLN3	1
GO:0005343	organic acid:sodium symporter activity	1/241	30/18367	0.327371004134369	0.505852935766949	SLC1A3	1
GO:0051020	GTPase binding	5/241	291/18367	0.335170697966032	0.512277308459721	PPP1R9A/IQGAP2/SPTBN1/HPS6/RAB11FIP1	5
GO:0004386	helicase activity	3/241	156/18367	0.336142454569205	0.512277308459721	HLTF/DDX24/DDX5	3
GO:0000146	microfilament motor activity	1/241	31/18367	0.336211249976307	0.512277308459721	MYH10	1
GO:0008157	protein phosphatase 1 binding	1/241	31/18367	0.336211249976307	0.512277308459721	PPP1R9A	1
GO:0140318	protein transporter activity	1/241	31/18367	0.336211249976307	0.512277308459721	LRP2	1
GO:0005216	ion channel activity	7/241	432/18367	0.339585423058344	0.515012525118486	MCOLN3/KCNN4/CLDN4/ITGAV/TMEM150C/GABRE/TMC5	7
GO:0051213	dioxygenase activity	2/241	92/18367	0.340628666029264	0.515012525118486	P3H2/P4HB	2
GO:0016741	transferase activity, transferring one-carbon groups	4/241	225/18367	0.341922315271069	0.515012525118486	METTL7A/MTR/TARBP1/DNMT3A	4
GO:0016853	isomerase activity	3/241	158/18367	0.343317580911007	0.515012525118486	PDIA5/P4HB/PDIA3	3
GO:0008175	tRNA methyltransferase activity	1/241	32/18367	0.344935785794136	0.515012525118486	TARBP1	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/241	32/18367	0.344935785794136	0.515012525118486	SLC19A1	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/241	32/18367	0.344935785794136	0.515012525118486	HLTF	1
GO:0001664	G protein-coupled receptor binding	5/241	295/18367	0.345538568041105	0.515012525118486	ITGB4/ADRB1/CALM1/WLS/GNAQ	5
GO:0031625	ubiquitin protein ligase binding	5/241	297/18367	0.350730891896005	0.521266112073079	JUN/HSPA5/VCL/HLTF/USP25	5
GO:0005154	epidermal growth factor receptor binding	1/241	33/18367	0.353546119888688	0.521266112073079	EFEMP1	1
GO:0008200	ion channel inhibitor activity	1/241	33/18367	0.353546119888688	0.521266112073079	CALM1	1
GO:0031369	translation initiation factor binding	1/241	33/18367	0.353546119888688	0.521266112073079	TBL2	1
GO:0016248	channel inhibitor activity	1/241	34/18367	0.362043740981021	0.528101136844315	CALM1	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/241	34/18367	0.362043740981021	0.528101136844315	CALM1	1
GO:0045505	dynein intermediate chain binding	1/241	34/18367	0.362043740981021	0.528101136844315	HTT	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/241	34/18367	0.362043740981021	0.528101136844315	SACM1L	1
GO:0019207	kinase regulator activity	4/241	233/18367	0.365740756962127	0.532074984197563	EFNA5/CALM1/KIDINS220/HYAL2	4
GO:0042605	peptide antigen binding	1/241	36/18367	0.378706702659828	0.549476303328716	DHCR24	1
GO:0030295	protein kinase activator activity	2/241	101/18367	0.383158526258723	0.552534161887958	EFNA5/CALM1	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/241	37/18367	0.386874925051349	0.552534161887958	GAPDH	1
GO:0030551	cyclic nucleotide binding	1/241	37/18367	0.386874925051349	0.552534161887958	SLC19A1	1
GO:0043531	ADP binding	1/241	37/18367	0.386874925051349	0.552534161887958	MYH10	1
GO:0046915	transition metal ion transmembrane transporter activity	1/241	37/18367	0.386874925051349	0.552534161887958	SLC39A10	1
GO:0071949	FAD binding	1/241	37/18367	0.386874925051349	0.552534161887958	DHCR24	1
GO:0005200	structural constituent of cytoskeleton	2/241	103/18367	0.392455934393697	0.55821731421666	SPTBN1/KRT19	2
GO:0005501	retinoid binding	1/241	38/18367	0.394936198540854	0.55821731421666	NR2F2	1
GO:0015175	neutral amino acid transmembrane transporter activity	1/241	38/18367	0.394936198540854	0.55821731421666	SLC38A9	1
GO:0019840	isoprenoid binding	1/241	38/18367	0.394936198540854	0.55821731421666	NR2F2	1
GO:1901981	phosphatidylinositol phosphate binding	3/241	173/18367	0.396786733045042	0.559387481895974	SVIL/IQGAP2/PLEKHA8	3
GO:0044389	ubiquitin-like protein ligase binding	5/241	316/18367	0.400139203389471	0.562198670848112	JUN/HSPA5/VCL/HLTF/USP25	5
GO:1990782	protein tyrosine kinase binding	2/241	105/18367	0.401690048271082	0.562198670848112	ITGB1/HYAL2	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	1/241	39/18367	0.402891917682742	0.562198670848112	IQGAP2	1
GO:0032451	demethylase activity	1/241	39/18367	0.402891917682742	0.562198670848112	JARID2	1
GO:0017080	sodium channel regulator activity	1/241	40/18367	0.410743458922291	0.566093809831213	ATP2B4	1
GO:0042169	SH2 domain binding	1/241	40/18367	0.410743458922291	0.566093809831213	DAG1	1
GO:0044183	protein folding chaperone	1/241	40/18367	0.410743458922291	0.566093809831213	HSPA5	1
GO:0019208	phosphatase regulator activity	2/241	107/18367	0.410857847354646	0.566093809831213	CALM1/RCAN1	2
GO:0019209	kinase activator activity	2/241	107/18367	0.410857847354646	0.566093809831213	EFNA5/CALM1	2
GO:0030331	estrogen receptor binding	1/241	41/18367	0.418492180829844	0.573722363192794	ISL1	1
GO:0048487	beta-tubulin binding	1/241	41/18367	0.418492180829844	0.573722363192794	HTT	1
GO:0008047	enzyme activator activity	2/241	110/18367	0.424479086182905	0.578103193276473	CALM1/MMP15	2
GO:0047485	protein N-terminus binding	2/241	110/18367	0.424479086182905	0.578103193276473	CALM1/SRRM2	2
GO:0015399	primary active transmembrane transporter activity	3/241	181/18367	0.424858288294593	0.578103193276473	SLC26A2/ATP2B1/ATP2B4	3
GO:0004222	metalloendopeptidase activity	2/241	111/18367	0.428983406098511	0.580826542415558	ADAMTS1/MMP15	2
GO:0030594	neurotransmitter receptor activity	2/241	111/18367	0.428983406098511	0.580826542415558	ADRB1/GABRE	2
GO:0004180	carboxypeptidase activity	1/241	43/18367	0.433686512939667	0.584301779748763	CPQ	1
GO:0030544	Hsp70 protein binding	1/241	43/18367	0.433686512939667	0.584301779748763	DNAJB14	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/241	44/18367	0.441134752973586	0.58997728576174	GAPDH	1
GO:0022839	ion gated channel activity	1/241	44/18367	0.441134752973586	0.58997728576174	KCNN4	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/241	44/18367	0.441134752973586	0.58997728576174	GABRE	1
GO:0005245	voltage-gated calcium channel activity	1/241	45/18367	0.44848543378641	0.596889372946877	ITGAV	1
GO:0048156	tau protein binding	1/241	45/18367	0.44848543378641	0.596889372946877	LGMN	1
GO:0035254	glutamate receptor binding	1/241	47/18367	0.462899191633664	0.614577324814597	CALM1	1
GO:0005262	calcium channel activity	2/241	119/18367	0.464326948631566	0.614980244313478	MCOLN3/ITGAV	2
GO:0070888	E-box binding	1/241	48/18367	0.469964764494815	0.619447532960636	SREBF2	1
GO:0120013	lipid transfer activity	1/241	48/18367	0.469964764494815	0.619447532960636	PLEKHA8	1
GO:0017171	serine hydrolase activity	3/241	195/18367	0.472822043330492	0.621715523321585	NCEH1/CTSV/DPP4	3
GO:0016829	lyase activity	3/241	196/18367	0.476180889575444	0.624126699298253	HACD3/GLDC/APMAP	3
GO:0043539	protein serine/threonine kinase activator activity	1/241	49/18367	0.47693777021329	0.624126699298253	CALM1	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/241	50/18367	0.48381941653814	0.63162105213929	MAN2A2	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/241	124/18367	0.485755877046882	0.632639201772963	LDHA/RDH14	2
GO:0008227	G protein-coupled amine receptor activity	1/241	51/18367	0.490610895525655	0.635934028086571	ADRB1	1
GO:0051018	protein kinase A binding	1/241	51/18367	0.490610895525655	0.635934028086571	AKAP9	1
GO:0004879	nuclear receptor activity	1/241	52/18367	0.497313383742423	0.641581181384682	NR2F2	1
GO:0098531	ligand-activated transcription factor activity	1/241	52/18367	0.497313383742423	0.641581181384682	NR2F2	1
GO:0050661	NADP binding	1/241	53/18367	0.503928042465768	0.647062533400881	GAPDH	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/241	53/18367	0.503928042465768	0.647062533400881	SLC6A4	1
GO:0016298	lipase activity	2/241	129/18367	0.506646583775782	0.649029698654222	NCEH1/PDIA3	2
GO:0008408	3'-5' exonuclease activity	1/241	54/18367	0.510456017881611	0.649732181993382	APEX2	1
GO:0015459	potassium channel regulator activity	1/241	54/18367	0.510456017881611	0.649732181993382	AKAP9	1
GO:0015078	proton transmembrane transporter activity	2/241	130/18367	0.510758388038673	0.649732181993382	ATP6V1B1/SLC46A1	2
GO:0030170	pyridoxal phosphate binding	1/241	55/18367	0.516898441279773	0.656017279304027	GLDC	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	1/241	56/18367	0.523256429246766	0.661019091912196	CST3	1
GO:0070279	vitamin B6 binding	1/241	56/18367	0.523256429246766	0.661019091912196	GLDC	1
GO:0042578	phosphoric ester hydrolase activity	5/241	366/18367	0.526602004104834	0.66371266415978	SACM1L/APEX2/PLPP3/CTDSPL/PDIA3	5
GO:0004536	deoxyribonuclease activity	1/241	57/18367	0.5295310838561	0.66434289648919	APEX2	1
GO:0005548	phospholipid transporter activity	1/241	57/18367	0.5295310838561	0.66434289648919	PLEKHA8	1
GO:0060090	molecular adaptor activity	5/241	369/18367	0.533856425858597	0.667518794059925	COL14A1/AKAP9/SYNE2/CUX1/WWC1	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	2/241	136/18367	0.534954193738082	0.667518794059925	LDHA/RDH14	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/241	58/18367	0.535723492856138	0.667518794059925	SLC27A2	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/241	59/18367	0.541834729855519	0.673599084615838	APEX2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/241	60/18367	0.547865854506208	0.676484474977192	DHCR24	1
GO:0022824	transmitter-gated ion channel activity	1/241	60/18367	0.547865854506208	0.676484474977192	GABRE	1
GO:0022835	transmitter-gated channel activity	1/241	60/18367	0.547865854506208	0.676484474977192	GABRE	1
GO:0043621	protein self-association	1/241	61/18367	0.553817912684173	0.682293689725772	SVIP	1
GO:0015276	ligand-gated ion channel activity	2/241	143/18367	0.562133322435793	0.688627006077424	MCOLN3/GABRE	2
GO:0022834	ligand-gated channel activity	2/241	143/18367	0.562133322435793	0.688627006077424	MCOLN3/GABRE	2
GO:0005085	guanyl-nucleotide exchange factor activity	3/241	223/18367	0.562735414472776	0.688627006077424	RGL3/ADRB1/DOCK9	3
GO:0016922	nuclear receptor binding	2/241	144/18367	0.56592247297359	0.690981233742308	ISL1/DDX5	2
GO:0061630	ubiquitin protein ligase activity	4/241	304/18367	0.567244073827543	0.691052357201929	RNF216/UBR4/HLTF/HUWE1	4
GO:0016836	hydro-lyase activity	1/241	64/18367	0.571209944230775	0.694337421098297	HACD3	1
GO:0008173	RNA methyltransferase activity	1/241	65/18367	0.576855925951825	0.696910007719992	TARBP1	1
GO:0030145	manganese ion binding	1/241	65/18367	0.576855925951825	0.696910007719992	EXTL2	1
GO:0008528	G protein-coupled peptide receptor activity	2/241	147/18367	0.577148507307416	0.696910007719992	LGR5/LGR4	2
GO:0140097	catalytic activity, acting on DNA	3/241	229/18367	0.580768583233421	0.699736596979474	HLTF/APEX2/DNMT3A	3
GO:0002039	p53 binding	1/241	66/18367	0.582427870102497	0.700193505375969	HTT	1
GO:0140677	molecular function activator activity	2/241	150/18367	0.588161795983102	0.70553618947973	CALM1/MMP15	2
GO:0015081	sodium ion transmembrane transporter activity	2/241	152/18367	0.595385544821602	0.712638715574215	SLC6A4/SLC1A3	2
GO:0061659	ubiquitin-like protein ligase activity	4/241	316/18367	0.59787224449287	0.713795506234688	RNF216/UBR4/HLTF/HUWE1	4
GO:0001653	peptide receptor activity	2/241	153/18367	0.598961859893459	0.713795506234688	LGR5/LGR4	2
GO:0005319	lipid transporter activity	2/241	154/18367	0.60251446701997	0.716468290130268	SLC27A2/PLEKHA8	2
GO:0004860	protein kinase inhibitor activity	1/241	70/18367	0.603994421072987	0.716670169906559	HYAL2	1
GO:0015079	potassium ion transmembrane transporter activity	2/241	155/18367	0.60604337003213	0.71703886337499	KCNN4/SLC12A9	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/241	71/18367	0.609210431595008	0.71703886337499	ASAH1	1
GO:0031491	nucleosome binding	1/241	71/18367	0.609210431595008	0.71703886337499	MLLT6	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/241	156/18367	0.609548576726454	0.71703886337499	TARBP1/DNMT3A	2
GO:0000049	tRNA binding	1/241	72/18367	0.614358020466105	0.717865742783964	NEMF	1
GO:0030276	clathrin binding	1/241	72/18367	0.614358020466105	0.717865742783964	LRP1	1
GO:0048018	receptor ligand activity	6/241	487/18367	0.618930248189048	0.717865742783964	FBN1/SEMA6A/SEMA6D/BMP7/DPP4/EFEMP1	6
GO:0005230	extracellular ligand-gated ion channel activity	1/241	73/18367	0.619438081524737	0.717865742783964	GABRE	1
GO:0033293	monocarboxylic acid binding	1/241	73/18367	0.619438081524737	0.717865742783964	NR2F2	1
GO:0106306	protein serine phosphatase activity	1/241	73/18367	0.619438081524737	0.717865742783964	CTDSPL	1
GO:0106307	protein threonine phosphatase activity	1/241	73/18367	0.619438081524737	0.717865742783964	CTDSPL	1
GO:0140030	modification-dependent protein binding	2/241	160/18367	0.623332729288596	0.719105197575742	MPHOSPH8/MORC4	2
GO:0019210	kinase inhibitor activity	1/241	74/18367	0.624451496980763	0.719105197575742	HYAL2	1
GO:0019905	syntaxin binding	1/241	74/18367	0.624451496980763	0.719105197575742	SLC6A4	1
GO:0046982	protein heterodimerization activity	4/241	328/18367	0.627179506785613	0.720729391201113	TENM3/ADRB1/ITGB1/P4HB	4
GO:0008083	growth factor activity	2/241	162/18367	0.630083104724082	0.722548130574577	BMP7/EFEMP1	2
GO:0016874	ligase activity	2/241	165/18367	0.640032221764928	0.732421810262376	SLC27A2/ACSS1	2
GO:0030971	receptor tyrosine kinase binding	1/241	78/18367	0.643855948357709	0.735259298020181	HYAL2	1
GO:0016835	carbon-oxygen lyase activity	1/241	79/18367	0.648548972385583	0.739075599781071	HACD3	1
GO:0004527	exonuclease activity	1/241	80/18367	0.653180408171622	0.742805994324069	APEX2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	2/241	170/18367	0.656146307598593	0.744630768166868	P3H2/P4HB	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	1/241	82/18367	0.662261724225691	0.75001483054131	SVIL	1
GO:0031267	small GTPase binding	3/241	259/18367	0.663649522252055	0.750033654280732	IQGAP2/HPS6/RAB11FIP1	3
GO:0004252	serine-type endopeptidase activity	2/241	174/18367	0.668620258491826	0.75409336370109	CTSV/DPP4	2
GO:0003713	transcription coactivator activity	3/241	262/18367	0.671251115401838	0.755502798610711	WWC1/RERE/HYAL2	3
GO:0050660	flavin adenine dinucleotide binding	1/241	85/18367	0.67544157187409	0.758658192638865	DHCR24	1
GO:0016209	antioxidant activity	1/241	86/18367	0.679720019591973	0.760341208009835	SOD3	1
GO:0042562	hormone binding	1/241	86/18367	0.679720019591973	0.760341208009835	LRP2	1
GO:0008276	protein methyltransferase activity	1/241	88/18367	0.688109142082834	0.766590021831589	DNMT3A	1
GO:0051219	phosphoprotein binding	1/241	88/18367	0.688109142082834	0.766590021831589	TBL2	1
GO:0005126	cytokine receptor binding	3/241	271/18367	0.693300728187625	0.769240361701076	EFNA5/IL6ST/TGFBR3	3
GO:0035091	phosphatidylinositol binding	3/241	271/18367	0.693300728187625	0.769240361701076	SVIL/IQGAP2/PLEKHA8	3
GO:0016791	phosphatase activity	3/241	275/18367	0.702738148979746	0.778133132574739	SACM1L/PLPP3/CTDSPL	3
GO:0043130	ubiquitin binding	1/241	92/18367	0.704236525775058	0.778216928482741	USP25	1
GO:0008236	serine-type peptidase activity	2/241	191/18367	0.717601720435597	0.791387381206193	CTSV/DPP4	2
GO:0004896	cytokine receptor activity	1/241	97/18367	0.723232709998132	0.795992539977823	IL6ST	1
GO:0004722	protein serine/threonine phosphatase activity	1/241	98/18367	0.726883553834501	0.79840422479412	CTDSPL	1
GO:0003730	mRNA 3'-UTR binding	2/241	201/18367	0.743482694300084	0.815000067699691	PUM1/DDX5	2
GO:0004620	phospholipase activity	1/241	104/18367	0.747803110106279	0.815934873976641	PDIA3	1
GO:0030674	protein-macromolecule adaptor activity	3/241	296/18367	0.748683073723522	0.815934873976641	COL14A1/SYNE2/CUX1	3
GO:0004674	protein serine/threonine kinase activity	4/241	386/18367	0.748810432790263	0.815934873976641	LATS2/AAK1/TGFBR3/SLK	4
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	3/241	299/18367	0.754762269856906	0.820785211951745	JUN/ISL1/DDX5	3
GO:1902936	phosphatidylinositol bisphosphate binding	1/241	107/18367	0.75765650259846	0.822297831193169	SVIL	1
GO:0140297	DNA-binding transcription factor binding	4/241	394/18367	0.7629502615057	0.826077773465666	JUN/ISL1/TLE4/DDX5	4
GO:0000149	SNARE binding	1/241	110/18367	0.767126455762962	0.826077773465666	SLC6A4	1
GO:0019001	guanyl nucleotide binding	4/241	398/18367	0.76978601615463	0.826077773465666	ARL4D/IFT27/GNAQ/SLC19A1	4
GO:0032561	guanyl ribonucleotide binding	4/241	398/18367	0.76978601615463	0.826077773465666	ARL4D/IFT27/GNAQ/SLC19A1	4
GO:0008094	ATP-dependent activity, acting on DNA	1/241	111/18367	0.770200483487184	0.826077773465666	HLTF	1
GO:0032182	ubiquitin-like protein binding	1/241	111/18367	0.770200483487184	0.826077773465666	USP25	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	3/241	310/18367	0.776049305149539	0.827597407228373	JUN/NFE2L3/SREBF2	3
GO:0004843	thiol-dependent deubiquitinase	1/241	113/18367	0.776227831173988	0.827597407228373	USP25	1
GO:0099094	ligand-gated cation channel activity	1/241	113/18367	0.776227831173988	0.827597407228373	MCOLN3	1
GO:0003774	cytoskeletal motor activity	1/241	114/18367	0.779182202417938	0.827597407228373	MYH10	1
GO:0101005	deubiquitinase activity	1/241	114/18367	0.779182202417938	0.827597407228373	USP25	1
GO:0001217	DNA-binding transcription repressor activity	3/241	313/18367	0.781586297408285	0.828542063337853	JUN/NFE2L3/SREBF2	3
GO:0005267	potassium channel activity	1/241	121/18367	0.798803149328203	0.845155363022295	KCNN4	1
GO:0005179	hormone activity	1/241	122/18367	0.801460632667669	0.84633005032667	FBN1	1
GO:0140101	catalytic activity, acting on a tRNA	1/241	124/18367	0.80667118538382	0.848995816140929	TARBP1	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/241	125/18367	0.809225164681222	0.848995816140929	ASAH1	1
GO:0019783	ubiquitin-like protein-specific protease activity	1/241	125/18367	0.809225164681222	0.848995816140929	USP25	1
GO:0008242	omega peptidase activity	1/241	126/18367	0.811745542672222	0.848995816140929	USP25	1
GO:0009055	electron transfer activity	1/241	126/18367	0.811745542672222	0.848995816140929	GLDC	1
GO:0042826	histone deacetylase binding	1/241	127/18367	0.81423275961296	0.849971983794445	GLI3	1
GO:0140678	molecular function inhibitor activity	1/241	128/18367	0.816687250015004	0.8501951900718	CALM1	1
GO:0005261	cation channel activity	3/241	335/18367	0.818830490380604	0.8501951900718	MCOLN3/KCNN4/ITGAV	3
GO:0004519	endonuclease activity	1/241	129/18367	0.819109442719998	0.8501951900718	APEX2	1
GO:0003924	GTPase activity	3/241	337/18367	0.821934074618176	0.851199170174708	ARL4D/IFT27/GNAQ	3
GO:0004842	ubiquitin-protein transferase activity	4/241	433/18367	0.823188959821609	0.851199170174708	RNF216/UBR4/HLTF/HUWE1	4
GO:0016779	nucleotidyltransferase activity	1/241	132/18367	0.826186439560868	0.852686759320368	CDS1	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	4/241	450/18367	0.845211000593691	0.870678752024009	JUN/ISL1/PBX1/FOXC1	4
GO:0022843	voltage-gated cation channel activity	1/241	143/18367	0.849856153272547	0.872294054806433	ITGAV	1
GO:0140375	immune receptor activity	1/241	144/18367	0.851841703484428	0.872294054806433	IL6ST	1
GO:0001216	DNA-binding transcription activator activity	4/241	456/18367	0.852414842710712	0.872294054806433	JUN/ISL1/PBX1/FOXC1	4
GO:0106310	protein serine kinase activity	3/241	360/18367	0.854487669383481	0.872294054806433	LATS2/AAK1/SLK	3
GO:0019787	ubiquitin-like protein transferase activity	4/241	458/18367	0.854752492461148	0.872294054806433	RNF216/UBR4/HLTF/HUWE1	4
GO:0046906	tetrapyrrole binding	1/241	149/18367	0.861383996881781	0.877424667214775	MTR	1
GO:0005543	phospholipid binding	4/241	466/18367	0.863792460191873	0.877866245246656	SVIL/IQGAP2/SPTBN1/PLEKHA8	4
GO:0005506	iron ion binding	1/241	151/18367	0.865027250800636	0.877866245246656	P3H2	1
GO:0005525	GTP binding	3/241	377/18367	0.875104948332542	0.886448901366483	ARL4D/IFT27/GNAQ	3
GO:0140098	catalytic activity, acting on RNA	3/241	386/18367	0.884942096586255	0.894756611520668	TARBP1/DDX24/DDX5	3
GO:0003823	antigen binding	1/241	171/18367	0.896604188753332	0.904875445107145	DHCR24	1
GO:0004721	phosphoprotein phosphatase activity	1/241	174/18367	0.900658565309729	0.907293250873705	CTDSPL	1
GO:0005244	voltage-gated ion channel activity	1/241	201/18367	0.930713619389505	0.934129082212953	ITGAV	1
GO:0022832	voltage-gated channel activity	1/241	201/18367	0.930713619389505	0.934129082212953	ITGAV	1
GO:0004518	nuclease activity	1/241	210/18367	0.938562294112321	0.940281272672966	APEX2	1
GO:0005125	cytokine activity	1/241	235/18367	0.95601927506929	0.95601927506929	BMP7	1