ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0019838	growth factor binding	24/996	141/18367	5.60063347561487e-07	0.000527579673402921	LRP2/ITGB4/LIFR/EGFR/ITGAV/NRP2/FGFR2/GPC1/ITGA6/LTBP1/NRP1/TGFBR3/IL6ST/PTN/ACVR2B/ERBB3/IGF1R/TSKU/FLT1/CRIM1/PDGFA/COL4A1/GLG1/IL2RG	24
GO:0045296	cadherin binding	39/996	332/18367	4.72005684734245e-06	0.00217143683793836	CDH1/EGFR/NOTCH3/ITGA6/TRIM29/SWAP70/CTNNAL1/PAK6/COBLL1/CTTN/CALD1/CD46/EPN2/DOCK9/TJP1/TJP2/PDLIM1/FNBP1L/MPP7/MICALL1/KRT18/FMNL2/MB21D2/EPS8L2/PACSIN2/IDH1/FLNB/PRDX1/DIAPH3/ITGB1/PKP2/PDXDC1/LIMA1/ANK3/BSG/CD2AP/ANXA2/F11R/ATIC	39
GO:0005178	integrin binding	22/996	144/18367	1.01490682198207e-05	0.00217143683793836	LAMB1/FBN1/ITGB4/PLPP3/DST/EGFR/ITGAV/LAMA5/ITGB5/FERMT1/TSPAN4/MMP14/FBLN1/ITGB8/PTN/JAM3/PTK2/ACTN1/FERMT2/P4HB/ITGB1/F11R	22
GO:0001618	virus receptor activity	15/996	76/18367	1.1716599213763e-05	0.00217143683793836	DAG1/EGFR/ITGAV/ITGB5/TFRC/SLC52A1/CD46/LDLR/SLC1A5/SLC52A2/ITGB1/DPP4/SCARB2/BSG/F11R	15
GO:0098631	cell adhesion mediator activity	13/996	59/18367	1.27764376766666e-05	0.00217143683793836	CD200/BCAM/DSG2/DSP/DSC2/TRIM29/JAM3/PDLIM1/KRT18/ITGB1/PKP2/BSG/ANXA2	13
GO:0140272	exogenous protein binding	15/996	77/18367	1.38308078849577e-05	0.00217143683793836	DAG1/EGFR/ITGAV/ITGB5/TFRC/SLC52A1/CD46/LDLR/SLC1A5/SLC52A2/ITGB1/DPP4/SCARB2/BSG/F11R	15
GO:0008514	organic anion transmembrane transporter activity	25/996	185/18367	2.32087258256704e-05	0.00312323138968307	GJA1/SLC26A2/SLC35B4/SLC38A9/SLC19A1/SLC52A3/SLC16A1/ABCG2/SLC52A1/SLC16A12/SLC25A13/SLC2A1/SLC1A3/SLC29A1/SLC22A11/SLC13A3/SLC1A5/SLC25A4/SLC25A1/SLC35B2/SLC25A17/SLC52A2/SLC38A2/SLC35D1/SLC7A2	25
GO:0003779	actin binding	45/996	440/18367	3.32228713318061e-05	0.00385891808522794	DAG1/DST/EGFR/MYH10/SLC6A4/COBL/SCIN/FERMT1/PAWR/RAI14/SORBS1/SYNPO/INF2/MYO7A/CYFIP1/MICAL3/PPP1R9A/CTNNAL1/COBLL1/CTTN/CALD1/HOOK1/TMSB4X/TRIOBP/PDLIM1/WASL/PTK2/ACTN1/S100A4/HDAC6/FERMT2/P4HB/EPS8/FMNL2/EPS8L2/MSRB2/FLNB/DIAPH3/ITGB1/LIMA1/EPB41L3/MTSS1/ENAH/INPPL1/GSN	45
GO:0050840	extracellular matrix binding	12/996	56/18367	3.68686441263815e-05	0.00385891808522794	DAG1/ITGAV/BCAM/GPC1/ITGA6/ADGRG1/SMOC1/TINAGL1/SPARC/ITGB1/ADGRG6/ANXA2	12
GO:0008013	beta-catenin binding	15/996	85/18367	4.69902945831389e-05	0.00420499685679756	GJA1/CDH1/KANK1/DVL3/PTPRK/DLG5/DACT2/GLI3/AXIN2/FOXO4/TBL1X/HDAC6/CBY1/CD2AP/TCF7L2	15
GO:0098632	cell-cell adhesion mediator activity	11/996	49/18367	4.91029356950883e-05	0.00420499685679756	CD200/DSG2/DSP/DSC2/TRIM29/JAM3/PDLIM1/KRT18/PKP2/BSG/ANXA2	11
GO:0008509	anion transmembrane transporter activity	34/996	314/18367	9.8872931269424e-05	0.00776152510464978	GJA1/SLC6A4/SLC26A2/SLC35B4/GABRE/SLC38A9/SLC19A1/SLC52A3/CLDN4/SLC16A1/ABCG2/GPR89A/SLC52A1/SLC16A12/SLC25A13/SLC4A2/SLC2A1/SLC1A3/SLC29A1/FXYD3/SLC22A11/MFSD5/SLC13A3/SLC1A5/SLC25A4/SLC25A1/SLC35B2/SLC25A17/SLC52A2/SLC38A2/SLC35D1/SLC7A2/CLIC4/LRRC8D	34
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	5/996	11/18367	0.000162970487103777	0.011809092219366	CD200/DSG2/DSP/DSC2/PKP2	5
GO:0038024	cargo receptor activity	13/996	77/18367	0.00023480609318405	0.0157990956985268	LRP2/COLEC12/LRP1/SCARA3/TFRC/FOLR1/LRP6/PRSS12/DAB2/LDLR/OLR1/LGALS3BP/SCARB2	13
GO:0017154	semaphorin receptor activity	5/996	12/18367	0.000266913314304034	0.0167621561382933	PLXNB1/MET/NRP2/NRP1/PLXNB2	5
GO:0005518	collagen binding	12/996	69/18367	0.000304141333557202	0.0179063210131803	COL14A1/PCOLCE2/SERPINH1/ADGRG1/CTSL/P3H4/SPARC/C1QTNF1/PDGFA/ITGB1/ADGRG6/HSD17B12	12
GO:0031994	insulin-like growth factor I binding	5/996	13/18367	0.000414409630144833	0.0229631689174372	LRP2/ITGB4/ITGAV/ITGA6/IGF1R	5
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	6/996	20/18367	0.000503184990101362	0.0263333478153046	CDS1/DPAGT1/CDIPT/CHPT1/PIGF/AASDHPPT	6
GO:0043236	laminin binding	7/996	28/18367	0.000585371837608966	0.0290221195277709	DAG1/BCAM/GPC1/ITGA6/TINAGL1/ITGB1/ADGRG6	7
GO:0019199	transmembrane receptor protein kinase activity	18/996	143/18367	0.000738738403993116	0.0347945788280758	EGFR/MET/NRP2/FGFR2/LTBP1/EFEMP1/NRP1/WEE1/TGFBR3/FER/ACVR2B/ERBB3/IGF1R/FLT1/EPHB4/YES1/PTK2/CRIM1	18
GO:0005041	low-density lipoprotein particle receptor activity	5/996	15/18367	0.000882886123022222	0.0396037489469968	LRP2/LRP1/LRP6/LDLR/OLR1	5
GO:0002020	protease binding	17/996	135/18367	0.00101954156211093	0.0432329973699198	ADAMTSL4/ITGAV/LRP1/DVL3/LDLR/TIMP3/SPATA2/CLTC/PINK1/ITGB1/CST3/PSAP/BRCA2/DPP4/FLOT2/ANXA2/BCL10	17
GO:0003713	transcription coactivator activity	27/996	262/18367	0.00105558273833138	0.0432329973699198	YAP1/WWC1/MAGED1/BRD4/RBPMS/MTA3/PDLIM1/PAGE4/SMARCA2/ACTN1/NCOA3/TRIM24/DCAF6/TRIM37/MYCBP/NUPR1/MED16/SERTAD2/DHX9/TRIM28/MED24/RERE/TRIP11/TRIM27/ENY2/TAF11/BCL10	27
GO:0090482	vitamin transmembrane transporter activity	7/996	31/18367	0.00112771440067939	0.0442627902266661	SLC19A3/SLC19A1/SLC52A3/ABCG2/SLC52A1/SLC2A1/SLC52A2	7
GO:0003712	transcription coregulator activity	43/996	489/18367	0.0012615218239793	0.04753414232754	KCTD1/KDM5B/PTPN14/YAP1/PAWR/WWC1/MAGED1/BRD4/RBPMS/MTA3/RCOR1/TFAP2A/PDLIM1/PAGE4/ARID3A/SMARCA2/CCND1/ACTN1/BASP1/NCOA3/TBL1X/CBX4/TRIM24/ATN1/DCAF6/ZNF451/TRIM37/MYCBP/NUPR1/MED16/SERTAD2/DHX9/SIN3B/TRIM28/MED24/RERE/KMT5A/TRIP11/TRIM27/ENY2/DDX1/TAF11/BCL10	43
GO:0008022	protein C-terminus binding	21/996	189/18367	0.00144594644063329	0.0506068678495728	DST/HIC2/BCAM/YAP1/FBLN1/PPARG/SIAH1/PPP1R9A/ID1/CENPF/DAB2/HRAS/SYNJ1/TBL1X/TOP2A/PPP2CB/TOPBP1/BRCA2/CD2AP/BCL10/CEP135	21
GO:0019789	SUMO transferase activity	6/996	24/18367	0.00145051532052916	0.0506068678495728	CBX4/MDM2/ZNF451/RANBP2/TRIM28/TRIM27	6
GO:0019205	nucleobase-containing compound kinase activity	8/996	42/18367	0.0016526905789043	0.0548423546727337	TK1/TJP2/MPP1/NME4/DTYMK/N4BP2/ADK/NME1	8
GO:0008201	heparin binding	19/996	166/18367	0.00168835274470199	0.0548423546727337	FBN1/ADAMTS1/CCDC80/APP/NRP2/FGFR2/BMP7/PCOLCE2/NRP1/APLP2/TGFBR3/PTN/ADGRG1/SMOC1/PTPRF/NAV2/FSTL1/HSD17B12/PGF	19
GO:0000295	adenine nucleotide transmembrane transporter activity	5/996	18/18367	0.00219884213652951	0.0647284153940874	SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17	5
GO:0005346	purine ribonucleotide transmembrane transporter activity	5/996	18/18367	0.00219884213652951	0.0647284153940874	SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17	5
GO:0030228	lipoprotein particle receptor activity	5/996	18/18367	0.00219884213652951	0.0647284153940874	LRP2/LRP1/LRP6/LDLR/OLR1	5
GO:0016853	isomerase activity	18/996	158/18367	0.00232302854072152	0.0663119056169599	FKBP9/CRELD1/PPIC/DEGS1/ISYNA1/DSEL/PTGES/GLCE/ECI1/GSTZ1/CYP2J2/P4HB/RPIA/TOP2A/PMM2/TOP1/RPE/ENOSF1	18
GO:1901681	sulfur compound binding	26/996	265/18367	0.0025830271698587	0.0715650468825557	FBN1/ADAMTS1/CCDC80/LRP1/APP/NRP2/FGFR2/BMP7/PCOLCE2/NRP1/APLP2/TGFBR3/PTN/ADGRG1/SMOC1/GSS/PTPRF/PTGES/NAV2/ACADVL/DHTKD1/GSTP1/FSTL1/METTL3/HSD17B12/PGF	26
GO:0015215	nucleotide transmembrane transporter activity	6/996	27/18367	0.00277590710835833	0.073977685844852	SLC19A1/SLC25A36/SLC29A1/SLC25A4/SLC35B2/SLC25A17	6
GO:0097718	disordered domain specific binding	7/996	36/18367	0.00282717270744657	0.073977685844852	GJA1/GJA5/AP2A2/NCOA3/MDM2/CLTC/RRM1	7
GO:0004714	transmembrane receptor protein tyrosine kinase activity	15/996	124/18367	0.00292311328827071	0.0742702848502421	EGFR/MET/NRP2/FGFR2/EFEMP1/NRP1/WEE1/FER/ERBB3/IGF1R/FLT1/EPHB4/YES1/PTK2/CRIM1	15
GO:0045295	gamma-catenin binding	4/996	12/18367	0.00299604121476561	0.0742702848502421	CDH1/DSC3/PTPRK/TCF7L2	4
GO:0046915	transition metal ion transmembrane transporter activity	7/996	37/18367	0.00332650310577	0.0794418230271512	SLC39A11/SLC39A10/SLC40A1/SLC11A2/SLC39A1/SLC39A3/SLC39A7	7
GO:0001968	fibronectin binding	6/996	28/18367	0.00337332581856268	0.0794418230271512	CCDC80/ITGAV/FBLN1/CTSL/ITGB1/HSD17B12	6
GO:0005520	insulin-like growth factor binding	6/996	29/18367	0.00406135651032531	0.09293128367628	LRP2/ITGB4/ITGAV/ITGA6/IGF1R/CRIM1	6
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	4/996	13/18367	0.00414343303015261	0.09293128367628	DUSP9/DUSP6/DUSP5/DUSP14	4
GO:0005385	zinc ion transmembrane transporter activity	5/996	21/18367	0.00456132899643536	0.0976539071509569	SLC39A11/SLC39A10/SLC39A1/SLC39A3/SLC39A7	5
GO:0015216	purine nucleotide transmembrane transporter activity	5/996	21/18367	0.00456132899643536	0.0976539071509569	SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17	5
GO:0051020	GTPase binding	27/996	291/18367	0.00466900916373369	0.0977379251608252	SH3BP4/DVL3/RASA1/ANKRD27/INF2/CYFIP1/MICAL3/PPP1R9A/CHML/ALS2/TRIOBP/RHOBTB3/EVI5/NCKAP1/TNPO1/EXPH5/FNBP1L/MICALL1/EPS8/FMNL2/DIAPH3/RANBP2/DENND5A/BIRC5/ANXA2/TRIP11/EXOC2	27
GO:0015932	nucleobase-containing compound transmembrane transporter activity	8/996	50/18367	0.00513150132028041	0.105084222689221	SLC35B4/SLC19A1/SLC25A36/SLC29A1/SLC25A4/SLC35B2/SLC25A17/SLC35D1	8
GO:0030276	clathrin binding	10/996	72/18367	0.00529534062937073	0.106132146231218	LRP1/SYT7/DAB2/LDLR/AP2A2/EPN2/NSG1/AP1S1/CLTC/AP1M2	10
GO:0015926	glucosidase activity	4/996	14/18367	0.00555442364300943	0.107195857316862	MOGS/GAA/AGL/GANAB	4
GO:0004602	glutathione peroxidase activity	5/996	22/18367	0.00564335534144789	0.107195857316862	MGST3/PTGES/GSTZ1/GPX8/GSTP1	5
GO:0005201	extracellular matrix structural constituent	18/996	172/18367	0.00575142802648162	0.107195857316862	LAMB1/FBN1/COL14A1/FBN2/LAMC1/FRAS1/COL4A2/VWA1/COL21A1/LAMA5/LTBP1/EFEMP1/FBLN1/CRELD1/TINAGL1/SPARC/MFAP5/COL4A1	18
GO:0004601	peroxidase activity	8/996	51/18367	0.00580359737065814	0.107195857316862	MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5	8
GO:0015605	organophosphate ester transmembrane transporter activity	6/996	32/18367	0.00674772880092657	0.109997169788055	SLC19A1/SLC25A36/SLC29A1/SLC25A4/SLC35B2/SLC25A17	6
GO:0005158	insulin receptor binding	5/996	23/18367	0.00689439157357183	0.109997169788055	SORBS1/IGF1R/SNX4/IRS2/PDPK1	5
GO:0017116	single-stranded DNA helicase activity	5/996	23/18367	0.00689439157357183	0.109997169788055	POLQ/MCM2/CHTF8/WRNIP1/DHX9	5
GO:0017134	fibroblast growth factor binding	5/996	23/18367	0.00689439157357183	0.109997169788055	ITGAV/FGFR2/GPC1/TGFBR3/GLG1	5
GO:0030215	semaphorin receptor binding	5/996	23/18367	0.00689439157357183	0.109997169788055	PLXNB1/SEMA6D/SEMA6A/SEMA3F/SEMA4C	5
GO:0004713	protein tyrosine kinase activity	15/996	136/18367	0.00695829321854122	0.109997169788055	EGFR/MET/NRP2/FGFR2/EFEMP1/NRP1/WEE1/FER/ERBB3/IGF1R/FLT1/EPHB4/YES1/PTK2/CRIM1	15
GO:0008094	ATP-dependent activity, acting on DNA	13/996	111/18367	0.00707413193156978	0.109997169788055	CHD7/POLQ/MCM2/CHTF8/SMARCA2/WRNIP1/NAV2/RAD54L2/TOP2A/DHX9/SMARCA1/RAD50/DDX1	13
GO:0005539	glycosaminoglycan binding	22/996	230/18367	0.00710089444737038	0.109997169788055	FBN1/ADAMTS1/EXTL2/CCDC80/APP/NRP2/FGFR2/BMP7/PCOLCE2/NRP1/APLP2/TGFBR3/PTN/ADGRG1/GNS/SMOC1/PTPRF/NAV2/FSTL1/HMMR/HSD17B12/PGF	22
GO:0019215	intermediate filament binding	4/996	15/18367	0.00725316455936842	0.109997169788055	FAM83H/PKP2/NME1/VIM	4
GO:0042809	vitamin D receptor binding	4/996	15/18367	0.00725316455936842	0.109997169788055	RXRA/MED16/MED24/TAF11	4
GO:0042813	Wnt-activated receptor activity	4/996	15/18367	0.00725316455936842	0.109997169788055	LRP5/FZD10/LRP6/FZD6	4
GO:0046943	carboxylic acid transmembrane transporter activity	17/996	163/18367	0.00739089688959095	0.109997169788055	SLC26A2/SLC27A2/SLC38A9/SLC19A1/SLC16A1/ABCG2/SLC16A12/SLC25A13/SLC1A3/SLC43A2/SLC13A3/SLC1A5/SLC25A1/SLC7A6/SLC16A4/SLC38A2/SLC7A2	17
GO:0031267	small GTPase binding	24/996	259/18367	0.0074732684357065	0.109997169788055	SH3BP4/DVL3/ANKRD27/INF2/CYFIP1/MICAL3/CHML/ALS2/TRIOBP/RHOBTB3/EVI5/NCKAP1/TNPO1/EXPH5/MICALL1/EPS8/FMNL2/DIAPH3/RANBP2/DENND5A/BIRC5/ANXA2/TRIP11/EXOC2	24
GO:0005342	organic acid transmembrane transporter activity	17/996	164/18367	0.00784245051102587	0.112150060590333	SLC26A2/SLC27A2/SLC38A9/SLC19A1/SLC16A1/ABCG2/SLC16A12/SLC25A13/SLC1A3/SLC43A2/SLC13A3/SLC1A5/SLC25A1/SLC7A6/SLC16A4/SLC38A2/SLC7A2	17
GO:0016504	peptidase activator activity	7/996	43/18367	0.0078576475572845	0.112150060590333	APP/PCOLCE2/FBLN1/PINK1/BCL2L13/PSME3/BAD	7
GO:0008375	acetylglucosaminyltransferase activity	7/996	44/18367	0.008917574809491	0.125378439858814	EXTL2/MGAT3/GCNT2/B3GNT5/B3GNT3/B4GAT1/EXT2	7
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	8/996	55/18367	0.00917911420755187	0.127157729169321	MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5	8
GO:0004386	helicase activity	16/996	156/18367	0.0106922595888065	0.144825440236546	CHD7/POLQ/MCM2/CHTF8/SMARCA2/WRNIP1/NAV2/RAD54L2/AQR/DHX32/DDX3Y/DHX9/SMARCA1/DHX15/RAD50/DDX1	16
GO:0030674	protein-macromolecule adaptor activity	26/996	296/18367	0.0107619753891277	0.144825440236546	COL14A1/OBSL1/SHANK2/SORBS1/FRMD4A/DDB1/CUX1/DLG5/ANKRD9/DAB2/AP2A2/TRIM6/TJP2/SPATA2/MPP7/EPS8/AP1S1/EPB41L3/BIN3/NUP153/ANK3/FEM1A/AP1M2/CBX5/RAD50/NAPA	26
GO:0070628	proteasome binding	4/996	17/18367	0.0116003524007055	0.153908900865698	ID1/WFS1/RAD23B/USP14	4
GO:0016757	glycosyltransferase activity	24/996	270/18367	0.0121346420841932	0.158761567268195	EXTL2/CHPF/MGAT3/PARP2/GALNT18/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/DPAGT1/AGL/FUT8/GALNT11/B3GNT3/B4GAT1/QPRT/STT3A/XYLT1/RPN2/PPAT/EXT2/ST3GAL6	24
GO:0004721	phosphoprotein phosphatase activity	17/996	174/18367	0.0136869494229376	0.162482471620274	PTPN14/UBASH3B/PTPRK/DUSP9/PDP2/CAMK2G/CTDSPL/PPP4R1/PTPRF/PPP1R3E/CPPED1/PPM1H/PHLPP1/DUSP6/DUSP5/PPP2CB/DUSP14	17
GO:0061134	peptidase regulator activity	21/996	230/18367	0.0137783820047179	0.162482471620274	ITIH5/APP/PCOLCE2/SPINT1/SERPINH1/APLP2/FBLN1/SPINT2/SERPINF1/TIMP3/CRIM1/PEBP1/PINK1/BCL2L13/CST3/PSME3/BIRC5/PRDX5/USP14/ANXA2/BAD	21
GO:0045499	chemorepellent activity	5/996	27/18367	0.0138320717351475	0.162482471620274	SEMA6D/SEMA6A/SEMA3F/SEMA4C/DPP4	5
GO:0015026	coreceptor activity	7/996	48/18367	0.0142199608966477	0.162482471620274	ITGAV/LRP1/LRP5/NRP1/TGFBR3/LRP6/ITGB1	7
GO:0016879	ligase activity, forming carbon-nitrogen bonds	7/996	48/18367	0.0142199608966477	0.162482471620274	GATB/GSS/GHDC/RIMKLB/ASNSD1/GCLM/ASS1	7
GO:0033549	MAP kinase phosphatase activity	4/996	18/18367	0.01428649819047	0.162482471620274	DUSP9/DUSP6/DUSP5/DUSP14	4
GO:0055102	lipase inhibitor activity	4/996	18/18367	0.01428649819047	0.162482471620274	ANXA5/FAF2/ANXA2/ANXA3	4
GO:0098641	cadherin binding involved in cell-cell adhesion	4/996	18/18367	0.01428649819047	0.162482471620274	TRIM29/PDLIM1/KRT18/ANXA2	4
GO:0004300	enoyl-CoA hydratase activity	3/996	10/18367	0.0143163961194084	0.162482471620274	ECI1/ECHDC2/HADHB	3
GO:0008097	5S rRNA binding	3/996	10/18367	0.0143163961194084	0.162482471620274	RPF2/MDM2/TST	3
GO:0008330	protein tyrosine/threonine phosphatase activity	3/996	10/18367	0.0143163961194084	0.162482471620274	DUSP9/DUSP6/DUSP5	3
GO:0003678	DNA helicase activity	9/996	72/18367	0.0154913311983257	0.173724214152653	CHD7/POLQ/MCM2/CHTF8/WRNIP1/NAV2/RAD54L2/DHX9/RAD50	9
GO:0003785	actin monomer binding	5/996	28/18367	0.0161057121517964	0.173724924401427	COBL/COBLL1/TMSB4X/LIMA1/MTSS1	5
GO:0015101	organic cation transmembrane transporter activity	5/996	28/18367	0.0161057121517964	0.173724924401427	SLC19A3/SLC29A1/ATP13A3/SLC44A1/SLC25A17	5
GO:0051861	glycolipid binding	5/996	28/18367	0.0161057121517964	0.173724924401427	PLEKHA8/PIGU/CLN3/PSAP/GPAA1	5
GO:0050660	flavin adenine dinucleotide binding	10/996	85/18367	0.0164936632047349	0.173724924401427	MICAL3/SQLE/CYB5R1/ACADS/DHCR24/ACADVL/COQ6/PPOX/TXNRD2/TXNRD1	10
GO:0015179	L-amino acid transmembrane transporter activity	8/996	61/18367	0.0167232903622325	0.173724924401427	SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/SLC7A6/SLC38A2/SLC7A2	8
GO:0106306	protein serine phosphatase activity	9/996	73/18367	0.0168477894544299	0.173724924401427	DUSP9/CTDSPL/CPPED1/PPM1H/PHLPP1/DUSP6/DUSP5/PPP2CB/DUSP14	9
GO:0106307	protein threonine phosphatase activity	9/996	73/18367	0.0168477894544299	0.173724924401427	DUSP9/CTDSPL/CPPED1/PPM1H/PHLPP1/DUSP6/DUSP5/PPP2CB/DUSP14	9
GO:0004722	protein serine/threonine phosphatase activity	11/996	98/18367	0.0170068998546707	0.173724924401427	DUSP9/PDP2/CAMK2G/CTDSPL/CPPED1/PPM1H/PHLPP1/DUSP6/DUSP5/PPP2CB/DUSP14	11
GO:0032182	ubiquitin-like protein binding	12/996	111/18367	0.0171590238231117	0.173724924401427	PELP1/TAB3/CBX4/HDAC6/MDM2/TOP2A/WDR48/N4BP2/RAD23B/FAF2/UCHL3/USP25	12
GO:0035615	clathrin adaptor activity	4/996	19/18367	0.017335608167446	0.173724924401427	DAB2/AP2A2/AP1S1/AP1M2	4
GO:0016209	antioxidant activity	10/996	86/18367	0.017788228631437	0.175553274246852	MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5/TXNRD2/TXNRD1	10
GO:0060090	molecular adaptor activity	30/996	369/18367	0.0178907795410804	0.175553274246852	COL14A1/OBSL1/SHANK2/SORBS1/FRMD4A/WWC1/DDB1/CUX1/DLG5/ANKRD9/DAB2/AP2A2/TRIM6/TJP2/SPATA2/MPP7/WWC3/EPS8/AP1S1/PDE4DIP/PKP2/EPB41L3/BIN3/NUP153/ANK3/FEM1A/AP1M2/CBX5/RAD50/NAPA	30
GO:1990841	promoter-specific chromatin binding	8/996	62/18367	0.0183181088675886	0.177893387147098	ISL1/CHD7/FOXO4/DHX9/TRIM28/DNMT1/FOXC1/ZNF750	8
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	3/996	11/18367	0.0189026701962071	0.178063153248271	DSEL/GLCE/RPE	3
GO:0061665	SUMO ligase activity	3/996	11/18367	0.0189026701962071	0.178063153248271	CBX4/ZNF451/RANBP2	3
GO:0097493	structural molecule activity conferring elasticity	3/996	11/18367	0.0189026701962071	0.178063153248271	FBN1/FBN2/LAMC1	3
GO:0030296	protein tyrosine kinase activator activity	4/996	20/18367	0.0207606636995459	0.187188802736206	EFNA5/ERBB3/CD24/CCL5	4
GO:0140312	cargo adaptor activity	4/996	20/18367	0.0207606636995459	0.187188802736206	DAB2/AP2A2/AP1S1/AP1M2	4
GO:0005543	phospholipid binding	36/996	466/18367	0.0209658383185071	0.187188802736206	OSBPL10/SCIN/ARHGAP32/SYT7/MME/KIF16B/NF1/PLEKHA8/WIPI2/MREG/PIGU/EPN2/PRKCI/SNX4/PLEKHA5/PARD3/PHLDA2/MYOF/MICALL1/FERMT2/ANXA5/RACGAP1/PACSIN2/PEBP1/SNX13/CYTH3/NME4/PXDC1/PSAP/MTSS1/SCARB2/GSN/GPAA1/ANXA2/BAD/ANXA3	36
GO:0005310	dicarboxylic acid transmembrane transporter activity	5/996	30/18367	0.0213683746222121	0.187188802736206	SLC26A2/SLC19A1/SLC25A13/SLC13A3/SLC1A5	5
GO:0017147	Wnt-protein binding	5/996	30/18367	0.0213683746222121	0.187188802736206	WLS/LRP5/FZD10/LRP6/FZD6	5
GO:0046966	thyroid hormone receptor binding	5/996	30/18367	0.0213683746222121	0.187188802736206	TRIP6/NCOA3/MED16/MED24/TAF11	5
GO:0004879	nuclear receptor activity	7/996	52/18367	0.0214611366194376	0.187188802736206	ESRRG/NR2F2/PPARG/ESRRA/PPARD/RXRA/NR2F6	7
GO:0098531	ligand-activated transcription factor activity	7/996	52/18367	0.0214611366194376	0.187188802736206	ESRRG/NR2F2/PPARG/ESRRA/PPARD/RXRA/NR2F6	7
GO:0016836	hydro-lyase activity	8/996	64/18367	0.0218289474511941	0.188650169715824	ACO1/ALAD/HACD3/ECI1/ECHDC2/FH/ENOSF1/HADHB	8
GO:0016877	ligase activity, forming carbon-sulfur bonds	6/996	41/18367	0.0221892276516879	0.190020476799	SLC27A2/ACSS1/ACSF2/UBA5/UBA6/SUCLA2	6
GO:1901505	carbohydrate derivative transmembrane transporter activity	7/996	53/18367	0.0236090469972162	0.200008744078945	SLC35B4/SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17/SLC35D1	7
GO:0017166	vinculin binding	3/996	12/18367	0.0242048798566876	0.200008744078945	DAG1/ACTN1/RTCB	3
GO:0043422	protein kinase B binding	3/996	12/18367	0.0242048798566876	0.200008744078945	PINK1/BAD/BCL10	3
GO:0061578	Lys63-specific deubiquitinase activity	3/996	12/18367	0.0242048798566876	0.200008744078945	BRCC3/USP27X/STAMBP	3
GO:0002039	p53 binding	8/996	66/18367	0.0257899959536479	0.208531094320081	TRIM29/BRD4/MDM2/TRIM24/TRIAP1/PSME3/PTTG1IP/KMT5A	8
GO:0003714	transcription corepressor activity	17/996	187/18367	0.0258331076026952	0.208531094320081	KCTD1/KDM5B/YAP1/PAWR/MTA3/RCOR1/TFAP2A/CCND1/BASP1/TBL1X/CBX4/ATN1/ZNF451/SIN3B/TRIM28/RERE/KMT5A	17
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	7/996	54/18367	0.0259003588486725	0.208531094320081	KDM5B/PLOD2/UTY/ASPH/TET2/P4HB/HSPBAP1	7
GO:0016835	carbon-oxygen lyase activity	9/996	79/18367	0.0268605046420223	0.214428774345635	ACO1/POLQ/ALAD/HACD3/ECI1/ECHDC2/FH/ENOSF1/HADHB	9
GO:0043130	ubiquitin binding	10/996	92/18367	0.0271714332596498	0.2150881523579	TAB3/HDAC6/MDM2/TOP2A/WDR48/N4BP2/RAD23B/FAF2/UCHL3/USP25	10
GO:0097110	scaffold protein binding	8/996	67/18367	0.0279471257321731	0.219384936997559	DSP/IL6ST/MAP3K7/KRT18/PSAP/DYNLL2/KRT8/VIM	8
GO:0008093	cytoskeletal anchor activity	4/996	22/18367	0.0287786977591028	0.222209289254712	OBSL1/EPB41L3/BIN3/ANK3	4
GO:0072349	modified amino acid transmembrane transporter activity	4/996	22/18367	0.0287786977591028	0.222209289254712	GJA1/SLC19A1/SLC16A12/SLC13A3	4
GO:0072341	modified amino acid binding	10/996	93/18367	0.0290242080005431	0.222282958833427	OSBPL10/SCIN/SYT7/SLC19A1/MME/FOLR1/GSS/PTGES/SCARB2/ANXA2	10
GO:0004859	phospholipase inhibitor activity	3/996	13/18367	0.0302233139046481	0.227762893585428	ANXA5/ANXA2/ANXA3	3
GO:0052650	NADP-retinol dehydrogenase activity	3/996	13/18367	0.0302233139046481	0.227762893585428	RDH10/RDH14/AKR1B1	3
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	10/996	94/18367	0.0309648142118219	0.231172067012307	NAGLU/MOGS/GAA/AGL/MAN2B2/MANBA/FUCA1/GANAB/NEU1/GUSB	10
GO:0005154	epidermal growth factor receptor binding	5/996	33/18367	0.0311665100961391	0.231172067012307	EFEMP1/FER/SNX4/YES1/VAV3	5
GO:0016874	ligase activity	15/996	165/18367	0.0347848739430119	0.255156113407263	SLC27A2/ACSS1/GATB/GSS/ACSF2/GHDC/RTCB/MDM2/RIMKLB/UBA5/ASNSD1/UBA6/GCLM/SUCLA2/ASS1	15
GO:0003697	single-stranded DNA binding	12/996	123/18367	0.0349417607532239	0.255156113407263	MCM2/SMC2/REXO4/DHX9/BRCA2/WDR48/SSBP3/SMARCA1/TOP1/RAD23B/NME1/RAD50	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	7/996	58/18367	0.0365720173639493	0.265006464283386	PTGES/PDSS2/TRIT1/GSTZ1/SMS/GSTP1/GSTA4	7
GO:0030165	PDZ domain binding	9/996	84/18367	0.0379336850171625	0.27195969225654	GJA1/ADRB1/CADM1/TGFBR3/GNG12/ATP2B1/CRIM1/GNG5/F11R	9
GO:0003707	steroid hormone receptor activity	4/996	24/18367	0.0383977060192355	0.27195969225654	ESRRG/ESRRA/PPARD/RXRA	4
GO:0050431	transforming growth factor beta binding	4/996	24/18367	0.0383977060192355	0.27195969225654	ITGAV/LTBP1/TGFBR3/TSKU	4
GO:0019955	cytokine binding	13/996	139/18367	0.0388880737868524	0.273377354531455	LIFR/ITGAV/PRLR/NRP2/CSF3R/LTBP1/CSF2RA/NRP1/TGFBR3/IL6ST/TSKU/ITGB1/IL2RG	13
GO:0004867	serine-type endopeptidase inhibitor activity	10/996	98/18367	0.0396413314959777	0.274793757350887	ITIH5/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/CRIM1/PEBP1/ANXA2	10
GO:0016758	hexosyltransferase activity	17/996	197/18367	0.0396729840761366	0.274793757350887	EXTL2/CHPF/MGAT3/GALNT18/GCNT2/B3GNT5/TMTC3/ALG6/UGGT2/AGL/FUT8/GALNT11/B3GNT3/B4GAT1/STT3A/RPN2/EXT2	17
GO:0005044	scavenger receptor activity	6/996	47/18367	0.0403938936532738	0.277744874608642	COLEC12/LRP1/SCARA3/PRSS12/LGALS3BP/SCARB2	6
GO:0042605	peptide antigen binding	5/996	36/18367	0.0433861673354144	0.296157750941742	HLA-B/HLA-A/HLA-C/DHCR24/HLA-E	5
GO:0032794	GTPase activating protein binding	3/996	15/18367	0.0443757001937994	0.29858506844685	PLXNB1/CDH1/GNAI1	3
GO:0043138	3'-5' DNA helicase activity	3/996	15/18367	0.0443757001937994	0.29858506844685	MCM2/NAV2/DHX9	3
GO:0008194	UDP-glycosyltransferase activity	13/996	143/18367	0.0470874805523035	0.314584444540921	EXTL2/CHPF/MGAT3/GALNT18/GCNT2/B3GNT5/GXYLT1/UGGT2/GALNT11/B3GNT3/B4GAT1/XYLT1/EXT2	13
GO:0071949	FAD binding	5/996	37/18367	0.0480143657664318	0.31851783487309	MICAL3/SQLE/CYB5R1/DHCR24/COQ6	5
GO:1901981	phosphatidylinositol phosphate binding	15/996	173/18367	0.049312583321647	0.324426011158175	SCIN/ARHGAP32/SYT7/KIF16B/PLEKHA8/WIPI2/PLEKHA5/PARD3/PHLDA2/FERMT2/RACGAP1/SNX13/CYTH3/GSN/ANXA2	15
GO:0004364	glutathione transferase activity	4/996	26/18367	0.0496395314331326	0.324426011158175	PTGES/GSTZ1/GSTP1/GSTA4	4
GO:0017124	SH3 domain binding	12/996	130/18367	0.0499381864309293	0.324426011158175	LRP2/GJA1/SHANK2/DOCK1/ELMO3/SOCS7/FUT8/SYNJ1/CYBA/ENAH/INPPL1/CD2AP	12
GO:0015172	acidic amino acid transmembrane transporter activity	3/996	16/18367	0.0524789054124059	0.332934665196483	SLC25A13/SLC1A3/SLC1A5	3
GO:0015556	C4-dicarboxylate transmembrane transporter activity	3/996	16/18367	0.0524789054124059	0.332934665196483	SLC25A13/SLC13A3/SLC1A5	3
GO:0032183	SUMO binding	3/996	16/18367	0.0524789054124059	0.332934665196483	PELP1/CBX4/USP25	3
GO:0008238	exopeptidase activity	10/996	103/18367	0.0526616402487007	0.332934665196483	ENPEP/CTSV/NAALAD2/TFRC/MME/MMP14/MMP15/CPQ/DPP4/CPVL	10
GO:0015631	tubulin binding	28/996	375/18367	0.0544191585201803	0.341752315506733	GJA1/DAG1/DST/KIF26B/HOOK2/KIF16B/CENPF/HOOK1/EML1/HDAC6/CAMSAP2/KIFC3/DPYSL2/RACGAP1/HOOK3/IFT74/BEX4/REEP1/MAP4K4/GABARAPL1/KATNBL1/BRCA2/GTSE1/BIRC5/TPX2/GPAA1/KIF4A/NME1	28
GO:0031625	ubiquitin protein ligase binding	23/996	297/18367	0.0548653977360149	0.342272878591563	EGFR/UBASH3B/ERBB3/TRAF4/WFS1/TRIOBP/AXIN2/PSMD1/HDAC6/FZD6/MDM2/PINK1/TRIM37/GABARAPL1/TRIM28/SMAD5/CACUL1/FAF2/CCDC50/RRAGA/USP25/BCL10/BAG1	23
GO:0051959	dynein light intermediate chain binding	4/996	27/18367	0.0558669157284344	0.343313031195446	HOOK2/HOOK1/HOOK3/DYNLL2	4
GO:0030695	GTPase regulator activity	35/996	488/18367	0.056125484930041	0.343313031195446	PLXNB1/NET1/ARHGAP23/ADRB1/PLEKHG4B/SYDE2/SH3BP4/ARHGAP32/NRP1/RASA1/SWAP70/ANKRD27/NF1/DOCK1/FAM13A/CHML/ALS2/ELMOD2/DOCK9/ARHGAP21/ARHGEF11/EVI5/HACD3/WASL/RACGAP1/BCAR3/EPS8L2/TBC1D4/CYTH3/TBC1D12/RANBP2/ARHGAP5/VAV3/DENND5A/DEPDC1	35
GO:0060589	nucleoside-triphosphatase regulator activity	35/996	488/18367	0.056125484930041	0.343313031195446	PLXNB1/NET1/ARHGAP23/ADRB1/PLEKHG4B/SYDE2/SH3BP4/ARHGAP32/NRP1/RASA1/SWAP70/ANKRD27/NF1/DOCK1/FAM13A/CHML/ALS2/ELMOD2/DOCK9/ARHGAP21/ARHGEF11/EVI5/HACD3/WASL/RACGAP1/BCAR3/EPS8L2/TBC1D4/CYTH3/TBC1D12/RANBP2/ARHGAP5/VAV3/DENND5A/DEPDC1	35
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	5/996	39/18367	0.0581125162034502	0.350910193997757	KIF16B/PARD3/FERMT2/RACGAP1/CYTH3	5
GO:0016776	phosphotransferase activity, phosphate group as acceptor	5/996	39/18367	0.0581125162034502	0.350910193997757	TJP2/MPP1/NME4/DTYMK/NME1	5
GO:1901682	sulfur compound transmembrane transporter activity	6/996	52/18367	0.0611974786083417	0.362809791280267	GJA1/SLC26A2/SLC19A3/ABCG2/SLC13A3/SLC35B2	6
GO:0015174	basic amino acid transmembrane transporter activity	3/996	17/18367	0.0612385953434846	0.362809791280267	SLC38A9/SLC7A6/SLC7A2	3
GO:0016854	racemase and epimerase activity	3/996	17/18367	0.0612385953434846	0.362809791280267	DSEL/GLCE/RPE	3
GO:0061135	endopeptidase regulator activity	16/996	194/18367	0.0627337396760864	0.369344892342958	ITIH5/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/TIMP3/CRIM1/PEBP1/CST3/PSME3/BIRC5/PRDX5/USP14/ANXA2	16
GO:0004177	aminopeptidase activity	5/996	40/18367	0.0635824450781533	0.370094637516366	ENPEP/CTSV/MMP14/MMP15/DPP4	5
GO:0015291	secondary active transmembrane transporter activity	19/996	240/18367	0.0636468484900757	0.370094637516366	SLC6A4/SLC26A2/SLC19A1/SLC16A1/SLC16A12/SLC4A2/SLC1A3/SLC22A11/SLC13A3/SLC1A5/SLC25A4/SLC11A2/SLC25A1/SLC7A6/SLC16A4/SLC38A2/SLC35D1/SLC35E1/SLC5A3	19
GO:0005096	GTPase activator activity	33/996	462/18367	0.0649398027620546	0.374015378696046	PLXNB1/NET1/ARHGAP23/ADRB1/PLEKHG4B/SYDE2/ARHGAP32/NRP1/RASA1/SWAP70/ANKRD27/NF1/DOCK1/FAM13A/CHML/ALS2/ELMOD2/DOCK9/ARHGAP21/ARHGEF11/EVI5/HACD3/RACGAP1/BCAR3/EPS8L2/TBC1D4/CYTH3/TBC1D12/RANBP2/ARHGAP5/VAV3/DENND5A/DEPDC1	33
GO:0004866	endopeptidase inhibitor activity	15/996	180/18367	0.0651152039343435	0.374015378696046	ITIH5/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/TIMP3/CRIM1/PEBP1/CST3/BIRC5/PRDX5/USP14/ANXA2	15
GO:0015301	anion:anion antiporter activity	4/996	29/18367	0.0695143958041307	0.39686400513631	SLC26A2/SLC19A1/SLC4A2/SLC25A4	4
GO:0004550	nucleoside diphosphate kinase activity	3/996	18/18367	0.0706290147740876	0.398398394713716	NME4/DTYMK/NME1	3
GO:0008301	DNA binding, bending	3/996	18/18367	0.0706290147740876	0.398398394713716	TFAM/TOP2A/FOXC1	3
GO:0016791	phosphatase activity	21/996	275/18367	0.0721308673728629	0.404448077769267	PLPP3/TNS3/PTPN14/UBASH3B/PTPRK/DUSP9/PDP2/CAMK2G/CTDSPL/SYNJ1/PPP4R1/PTPRF/PPP1R3E/CPPED1/PPM1H/PHLPP1/DUSP6/DUSP5/PPP2CB/DUSP14/INPPL1	21
GO:0140097	catalytic activity, acting on DNA	18/996	229/18367	0.0734046887632174	0.409155129082549	APEX2/CHD7/POLQ/MCM2/CHTF8/SMARCA2/WRNIP1/NAV2/FEN1/RAD54L2/TOP2A/DHX9/SMARCA1/TOP1/DNMT1/NME1/RAD50/DDX1	18
GO:0047485	protein N-terminus binding	10/996	110/18367	0.0752154044287344	0.416781829246281	PELP1/MYO7A/ID1/ZWINT/NCOA3/DCTN4/MDM2/EXOC2/TAF11/RBPJ	10
GO:0005080	protein kinase C binding	6/996	55/18367	0.0762327428915958	0.419948794174756	ITGAV/DSP/PRKCSH/DACT2/TOP2A/PKP2	6
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	3/996	19/18367	0.0806215285128328	0.44154348755284	LTBP1/TGFBR3/ACVR2B	3
GO:0032266	phosphatidylinositol-3-phosphate binding	5/996	43/18367	0.0816578010252497	0.444033880508763	KIF16B/WIPI2/PLEKHA5/PARD3/SNX13	5
GO:0051015	actin filament binding	17/996	217/18367	0.0820189970366505	0.444033880508763	EGFR/MYH10/SLC6A4/SCIN/FERMT1/MYO7A/CYFIP1/PPP1R9A/CTNNAL1/CTTN/TRIOBP/ACTN1/FERMT2/FMNL2/FLNB/LIMA1/GSN	17
GO:0030414	peptidase inhibitor activity	15/996	187/18367	0.0840051843515281	0.449392785332134	ITIH5/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/TIMP3/CRIM1/PEBP1/CST3/BIRC5/PRDX5/USP14/ANXA2	15
GO:0004857	enzyme inhibitor activity	7/996	70/18367	0.0843576907241103	0.449392785332134	PPP1R12B/ANXA5/ABCE1/FAF2/ANXA2/DFFA/ANXA3	7
GO:0016878	acid-thiol ligase activity	4/996	31/18367	0.0847063314847981	0.449392785332134	SLC27A2/ACSS1/ACSF2/SUCLA2	4
GO:0015171	amino acid transmembrane transporter activity	8/996	84/18367	0.0849171080563904	0.449392785332134	SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/SLC7A6/SLC38A2/SLC7A2	8
GO:0140297	DNA-binding transcription factor binding	28/996	394/18367	0.0876163240415888	0.461087023727244	TACC2/BHLHE41/ISL1/YAP1/PPARG/TEAD3/CENPF/WFS1/TRIM6/FOXO4/CEBPA/TRIP6/NCOA3/PPARD/TBX3/TRIM24/RXRA/MED16/GABARAPL1/DHX9/MED24/TCF7L2/KLF5/DCAF13/CBX5/TAF11/BCL10/RBPJ	28
GO:0016500	protein-hormone receptor activity	3/996	20/18367	0.0911852105387071	0.467504586653435	LGR4/LGR5/IGF1R	3
GO:0031683	G-protein beta/gamma-subunit complex binding	3/996	20/18367	0.0911852105387071	0.467504586653435	GNA12/GNAI1/GNA11	3
GO:0050145	nucleoside monophosphate kinase activity	3/996	20/18367	0.0911852105387071	0.467504586653435	TJP2/MPP1/DTYMK	3
GO:0016922	nuclear receptor binding	12/996	144/18367	0.0918139254836169	0.467504586653435	TACC2/ISL1/PPARG/TRIP6/NCOA3/TRIM24/RXRA/MED16/MED24/TCF7L2/DCAF13/TAF11	12
GO:0001223	transcription coactivator binding	4/996	32/18367	0.0928589830736418	0.467504586653435	EPAS1/PPARD/TFAM/VGLL4	4
GO:0050699	WW domain binding	4/996	32/18367	0.0928589830736418	0.467504586653435	TRAF4/TCEAL4/PRRG4/ENAH	4
GO:0140658	ATP-dependent chromatin remodeler activity	4/996	32/18367	0.0928589830736418	0.467504586653435	CHD7/SMARCA2/RAD54L2/SMARCA1	4
GO:0000287	magnesium ion binding	17/996	221/18367	0.093097000784365	0.467504586653435	WEE1/GNAI1/GSS/COMT/MVK/MAP3K7/FEN1/PINK1/ATP10D/IDH1/AASDHPPT/TOP2A/SUCLA2/RPS6KA4/ENOSF1/NME1/SRPK1	17
GO:0044389	ubiquitin-like protein ligase binding	23/996	316/18367	0.0933024015826388	0.467504586653435	EGFR/UBASH3B/ERBB3/TRAF4/WFS1/TRIOBP/AXIN2/PSMD1/HDAC6/FZD6/MDM2/PINK1/TRIM37/GABARAPL1/TRIM28/SMAD5/CACUL1/FAF2/CCDC50/RRAGA/USP25/BCL10/BAG1	23
GO:0005522	profilin binding	2/996	10/18367	0.0990148198898254	0.47675088433353	CTTN/ENAH	2
GO:0008239	dipeptidyl-peptidase activity	2/996	10/18367	0.0990148198898254	0.47675088433353	NAALAD2/DPP4	2
GO:0008641	ubiquitin-like modifier activating enzyme activity	2/996	10/18367	0.0990148198898254	0.47675088433353	UBA5/UBA6	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/996	10/18367	0.0990148198898254	0.47675088433353	SLC35B4/SLC35D1	2
GO:0016783	sulfurtransferase activity	2/996	10/18367	0.0990148198898254	0.47675088433353	TST/MOCS2	2
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2/996	10/18367	0.0990148198898254	0.47675088433353	GATB/ASNSD1	2
GO:0052813	phosphatidylinositol bisphosphate kinase activity	2/996	10/18367	0.0990148198898254	0.47675088433353	PIP5K1A/PIP5K1B	2
GO:0003727	single-stranded RNA binding	8/996	87/18367	0.0991965746596304	0.47675088433353	RBMS3/L1TD1/RBPMS/MSI2/CBX4/AQR/DHX9/DDX1	8
GO:0008017	microtubule binding	20/996	271/18367	0.100734660783245	0.479252780089982	DST/KIF26B/HOOK2/KIF16B/CENPF/HOOK1/EML1/HDAC6/CAMSAP2/KIFC3/DPYSL2/RACGAP1/HOOK3/REEP1/MAP4K4/KATNBL1/GTSE1/BIRC5/TPX2/KIF4A	20
GO:0035091	phosphatidylinositol binding	20/996	271/18367	0.100734660783245	0.479252780089982	SCIN/ARHGAP32/SYT7/KIF16B/PLEKHA8/WIPI2/MREG/PIGU/SNX4/PLEKHA5/PARD3/PHLDA2/FERMT2/RACGAP1/SNX13/CYTH3/PXDC1/GSN/GPAA1/ANXA2	20
GO:0140323	solute:anion antiporter activity	4/996	33/18367	0.101368289691228	0.479843863764508	SLC26A2/SLC19A1/SLC4A2/SLC25A4	4
GO:0061980	regulatory RNA binding	5/996	46/18367	0.102163408405369	0.481189653589288	KCNQ1OT1/SOX4/PUM1/PUM2/DHX9	5
GO:0051219	phosphoprotein binding	8/996	88/18367	0.104239158764687	0.488218820634939	UBASH3B/RASA1/SHB/PRKCSH/YES1/CBX4/BCAR3/RRAGA	8
GO:0001786	phosphatidylserine binding	6/996	60/18367	0.105496264504383	0.488218820634939	OSBPL10/SCIN/SYT7/MME/SCARB2/ANXA2	6
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	6/996	60/18367	0.105496264504383	0.488218820634939	ACADS/DHCR24/ACADVL/PPOX/DECR2/AKR1B1	6
GO:0003725	double-stranded RNA binding	7/996	74/18367	0.105728916570624	0.488218820634939	TFRC/ACTN1/CLTC/DHX9/DHX15/VIM/DDX1	7
GO:0008376	acetylgalactosaminyltransferase activity	4/996	34/18367	0.110222071457259	0.489076016320353	EXTL2/CHPF/GALNT18/GALNT11	4
GO:0035198	miRNA binding	4/996	34/18367	0.110222071457259	0.489076016320353	KCNQ1OT1/SOX4/PUM1/PUM2	4
GO:0043548	phosphatidylinositol 3-kinase binding	4/996	34/18367	0.110222071457259	0.489076016320353	IGF1R/IRS2/GSN/HCST	4
GO:0016829	lyase activity	15/996	196/18367	0.112992236150738	0.489076016320353	PISD/GLDC/ACO1/POLQ/ALAD/MGST3/ADSL/HACD3/ECI1/PDXDC1/ECHDC2/FH/ENOSF1/HADHB/AZIN1	15
GO:0005537	mannose binding	3/996	22/18367	0.113893998967258	0.489076016320353	LMAN1/MANBA/BSG	3
GO:0008106	alcohol dehydrogenase (NADP+) activity	3/996	22/18367	0.113893998967258	0.489076016320353	RDH10/RDH14/AKR1B1	3
GO:0016881	acid-amino acid ligase activity	3/996	22/18367	0.113893998967258	0.489076016320353	GSS/GHDC/GCLM	3
GO:0022804	active transmembrane transporter activity	28/996	406/18367	0.114433350098538	0.489076016320353	SLC6A4/SLC26A2/SLC19A1/SLC16A1/ABCG2/SLC16A12/SLC4A2/SLC1A3/SLC22A11/ATP2B1/SLC13A3/SLC1A5/SLC25A4/ATP13A3/CYC1/SLC11A2/SLC25A1/SLC7A6/SLC16A4/ATP6V1H/COX6A1/SLC38A2/SLC35D1/ATP6V1C2/SLC35E1/ABCB8/SURF1/SLC5A3	28
GO:0043177	organic acid binding	11/996	135/18367	0.115976689889794	0.489076016320353	NR2F2/GLDC/PLOD2/SLC19A1/PPARG/FOLR1/SLC1A3/GSS/PPARD/RXRA/ASS1	11
GO:0000774	adenyl-nucleotide exchange factor activity	2/996	11/18367	0.11681751982174	0.489076016320353	SIL1/BAG1	2
GO:0005347	ATP transmembrane transporter activity	2/996	11/18367	0.11681751982174	0.489076016320353	SLC25A4/SLC25A17	2
GO:0019107	myristoyltransferase activity	2/996	11/18367	0.11681751982174	0.489076016320353	ZDHHC3/HADHB	2
GO:0022889	serine transmembrane transporter activity	2/996	11/18367	0.11681751982174	0.489076016320353	SLC1A5/SLC38A2	2
GO:0035252	UDP-xylosyltransferase activity	2/996	11/18367	0.11681751982174	0.489076016320353	GXYLT1/XYLT1	2
GO:0035673	oligopeptide transmembrane transporter activity	2/996	11/18367	0.11681751982174	0.489076016320353	GJA1/SLC13A3	2
GO:0042285	xylosyltransferase activity	2/996	11/18367	0.11681751982174	0.489076016320353	GXYLT1/XYLT1	2
GO:0042608	T cell receptor binding	2/996	11/18367	0.11681751982174	0.489076016320353	HLA-A/HLA-E	2
GO:0043295	glutathione binding	2/996	11/18367	0.11681751982174	0.489076016320353	GSS/PTGES	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/996	11/18367	0.11681751982174	0.489076016320353	TXNRD2/TXNRD1	2
GO:0048407	platelet-derived growth factor binding	2/996	11/18367	0.11681751982174	0.489076016320353	PDGFA/COL4A1	2
GO:1901612	cardiolipin binding	2/996	11/18367	0.11681751982174	0.489076016320353	MME/NME4	2
GO:0042887	amide transmembrane transporter activity	4/996	35/18367	0.119407229556722	0.497706240010761	GJA1/SLC19A1/ABCG2/SLC13A3	4
GO:0016763	pentosyltransferase activity	5/996	49/18367	0.124964964813255	0.515930167691865	PARP2/GXYLT1/QPRT/XYLT1/PPAT	5
GO:0051213	dioxygenase activity	8/996	92/18367	0.125792101089279	0.515930167691865	KDM5B/PLOD2/UTY/ASPH/TET2/P4HB/HSPBAP1/CDO1	8
GO:0008143	poly(A) binding	3/996	23/18367	0.125970210795254	0.515930167691865	RBMS3/RBPMS/DDX1	3
GO:0140103	catalytic activity, acting on a glycoprotein	3/996	23/18367	0.125970210795254	0.515930167691865	MGAT3/FUT8/B3GNT3	3
GO:0042805	actinin binding	4/996	36/18367	0.128909862334385	0.523418492754272	DAG1/PPARG/PDLIM1/CSRP2	4
GO:0043394	proteoglycan binding	4/996	36/18367	0.128909862334385	0.523418492754272	LRP1/PTN/CTSL/PTPRF	4
GO:0019207	kinase regulator activity	17/996	233/18367	0.13177731359594	0.52513753627588	SOCS6/EFNA5/LRP6/ERBB3/ALS2/SOCS7/CDKN1C/CCND1/CD24/CCL5/PKIB/GSTP1/TPX2/RICTOR/CCNE1/CCNA2/BCL10	17
GO:0000993	RNA polymerase II complex binding	5/996	50/18367	0.133045431846997	0.52513753627588	BRD4/NCOA3/DHX9/WDR43/ZNF326	5
GO:0000340	RNA 7-methylguanosine cap binding	2/996	12/18367	0.135340047814751	0.52513753627588	CYFIP1/NCBP3	2
GO:0003995	acyl-CoA dehydrogenase activity	2/996	12/18367	0.135340047814751	0.52513753627588	ACADS/ACADVL	2
GO:0005024	transforming growth factor beta-activated receptor activity	2/996	12/18367	0.135340047814751	0.52513753627588	LTBP1/TGFBR3	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/996	12/18367	0.135340047814751	0.52513753627588	SLC35B4/SLC35D1	2
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/996	12/18367	0.135340047814751	0.52513753627588	BRD4/CDK6	2
GO:0008429	phosphatidylethanolamine binding	2/996	12/18367	0.135340047814751	0.52513753627588	NF1/PEBP1	2
GO:0097677	STAT family protein binding	2/996	12/18367	0.135340047814751	0.52513753627588	PPARG/CEBPA	2
GO:1900750	oligopeptide binding	2/996	12/18367	0.135340047814751	0.52513753627588	GSS/PTGES	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	10/996	124/18367	0.135981441948911	0.52513753627588	RDH10/HSD17B1/RDH14/IDH1/IMPDH2/GCLM/AKR1B1/HSD17B12/LDHB/HADHB	10
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	21/996	299/18367	0.13602288625405	0.52513753627588	TACC2/BHLHE41/ISL1/PPARG/TEAD3/CEBPA/TRIP6/NCOA3/PPARD/TBX3/TRIM24/RXRA/MED16/GABARAPL1/DHX9/MED24/TCF7L2/DCAF13/TAF11/BCL10/RBPJ	21
GO:0022853	active ion transmembrane transporter activity	19/996	267/18367	0.13784576530334	0.529027875302999	SLC6A4/SLC26A2/SLC19A1/SLC4A2/SLC1A3/SLC22A11/ATP2B1/SLC13A3/SLC25A4/ATP13A3/CYC1/SLC11A2/SLC25A1/ATP6V1H/COX6A1/SLC38A2/ATP6V1C2/SURF1/SLC5A3	19
GO:0070840	dynein complex binding	3/996	24/18367	0.138480568620399	0.529027875302999	CENPF/HDAC6/DCTN6	3
GO:0005109	frizzled binding	4/996	37/18367	0.138715377069895	0.529027875302999	RNF43/DVL3/LRP6/ZNRF3	4
GO:0042578	phosphoric ester hydrolase activity	25/996	366/18367	0.139824959951391	0.531109323686333	PLPP3/TNS3/PTPN14/UBASH3B/PTPRK/APEX2/NOTUM/DUSP9/PDP2/CAMK2G/CTDSPL/SYNJ1/PPP4R1/PTPRF/PPP1R3E/CPPED1/PPM1H/PHLPP1/CCL5/DUSP6/DUSP5/PPP2CB/DUSP14/INPPL1/PDE7A	25
GO:0016860	intramolecular oxidoreductase activity	5/996	51/18367	0.141353357474805	0.534758484904682	CRELD1/PTGES/ECI1/P4HB/RPIA	5
GO:0033218	amide binding	27/996	400/18367	0.142172420433457	0.535467085731807	ENPEP/PRLR/LRP1/CTSV/SLC19A1/MME/PPARG/FOLR1/PLEKHA8/PPIC/HLA-B/HLA-A/IGF1R/LDLR/GSS/HLA-C/PTGES/TNPO1/DHCR24/SLC40A1/HLA-E/ACADVL/RXRA/CST3/PSAP/NUP153/ITM2C	27
GO:0008047	enzyme activator activity	9/996	110/18367	0.142677535582467	0.535467085731807	PPP1R12B/MMP15/WRNIP1/CCL5/NUPR1/PSAP/DDOST/PDPK1/AZIN1	9
GO:0070851	growth factor receptor binding	11/996	141/18367	0.143808084014853	0.537568314055522	APP/EFEMP1/IL6ST/FER/SNX4/YES1/TRIP6/PDGFA/VAV3/CD2AP/PGF	11
GO:0015175	neutral amino acid transmembrane transporter activity	4/996	38/18367	0.148808597017775	0.551113464925305	SLC38A9/SLC43A2/SLC1A5/SLC38A2	4
GO:0031593	polyubiquitin modification-dependent protein binding	5/996	52/18367	0.149880578630811	0.551113464925305	AGL/BRCC3/TAB3/HDAC6/RAD23B	5
GO:0005160	transforming growth factor beta receptor binding	3/996	25/18367	0.15138941420031	0.551113464925305	RASL11B/TGFBR3/FERMT2	3
GO:0008234	cysteine-type peptidase activity	14/996	190/18367	0.151474888840472	0.551113464925305	USP43/CTSV/CTSL/BRCC3/USP27X/LGMN/USP47/STAMBP/GPAA1/USP14/ATG4C/UCHL3/CAPN7/USP25	14
GO:0042277	peptide binding	22/996	321/18367	0.154248911713038	0.551113464925305	ENPEP/PRLR/LRP1/CTSV/MME/PPARG/PPIC/HLA-B/HLA-A/IGF1R/LDLR/GSS/HLA-C/PTGES/TNPO1/DHCR24/SLC40A1/HLA-E/RXRA/CST3/NUP153/ITM2C	22
GO:0005542	folic acid binding	2/996	13/18367	0.154452181252952	0.551113464925305	SLC19A1/FOLR1	2
GO:0016594	glycine binding	2/996	13/18367	0.154452181252952	0.551113464925305	GLDC/GSS	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/996	13/18367	0.154452181252952	0.551113464925305	TXNRD2/TXNRD1	2
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	2/996	13/18367	0.154452181252952	0.551113464925305	SYNJ1/INPPL1	2
GO:0045159	myosin II binding	2/996	13/18367	0.154452181252952	0.551113464925305	TRIOBP/GSN	2
GO:0060590	ATPase regulator activity	2/996	13/18367	0.154452181252952	0.551113464925305	SIL1/BAG1	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/996	13/18367	0.154452181252952	0.551113464925305	HSD17B1/HSD17B12	2
GO:0140678	molecular function inhibitor activity	10/996	128/18367	0.157054946898809	0.558285886711992	RASA1/WNK2/ID1/PPP1R12B/ANXA5/ABCE1/FAF2/ANXA2/DFFA/ANXA3	10
GO:0031406	carboxylic acid binding	13/996	176/18367	0.160365681836849	0.567911549963579	NR2F2/GLDC/PLOD2/SLC19A1/PPARG/FOLR1/SLC1A3/GSS/PPARD/RXRA/GSTP1/PSAP/SIGLEC6	13
GO:0042169	SH2 domain binding	4/996	40/18367	0.169795132098599	0.588467259498787	DAG1/PTK2/ARHGAP5/INPPL1	4
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	4/996	40/18367	0.169795132098599	0.588467259498787	BCL2L13/BIRC5/PRDX5/BAD	4
GO:0005172	vascular endothelial growth factor receptor binding	2/996	14/18367	0.174035679283958	0.588467259498787	CD2AP/PGF	2
GO:0005313	L-glutamate transmembrane transporter activity	2/996	14/18367	0.174035679283958	0.588467259498787	SLC25A13/SLC1A3	2
GO:0008474	palmitoyl-(protein) hydrolase activity	2/996	14/18367	0.174035679283958	0.588467259498787	ABHD12/LYPLA1	2
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	2/996	14/18367	0.174035679283958	0.588467259498787	B3GNT5/B3GNT3	2
GO:0015562	efflux transmembrane transporter activity	2/996	14/18367	0.174035679283958	0.588467259498787	GJA1/ABCG2	2
GO:0019992	diacylglycerol binding	2/996	14/18367	0.174035679283958	0.588467259498787	CDIPT/CHPT1	2
GO:0036041	long-chain fatty acid binding	2/996	14/18367	0.174035679283958	0.588467259498787	PPARG/PPARD	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/996	14/18367	0.174035679283958	0.588467259498787	HSD17B1/HSD17B12	2
GO:0070411	I-SMAD binding	2/996	14/18367	0.174035679283958	0.588467259498787	AXIN2/SMAD5	2
GO:0098599	palmitoyl hydrolase activity	2/996	14/18367	0.174035679283958	0.588467259498787	ABHD12/LYPLA1	2
GO:0030170	pyridoxal phosphate binding	5/996	55/18367	0.176690979291894	0.588467259498787	GLDC/PSAT1/PDXDC1/ALAS1/SPTLC3	5
GO:0004709	MAP kinase kinase kinase activity	3/996	27/18367	0.178260415828391	0.588467259498787	EGFR/MAP3K7/MAP3K13	3
GO:0016405	CoA-ligase activity	3/996	27/18367	0.178260415828391	0.588467259498787	SLC27A2/ACSS1/ACSF2	3
GO:0030507	spectrin binding	3/996	27/18367	0.178260415828391	0.588467259498787	MYO7A/CAMSAP2/ANK3	3
GO:0043425	bHLH transcription factor binding	3/996	27/18367	0.178260415828391	0.588467259498787	BHLHE41/ISL1/KLF5	3
GO:0051393	alpha-actinin binding	3/996	27/18367	0.178260415828391	0.588467259498787	DAG1/PPARG/PDLIM1	3
GO:0070006	metalloaminopeptidase activity	3/996	27/18367	0.178260415828391	0.588467259498787	ENPEP/MMP14/MMP15	3
GO:0019902	phosphatase binding	14/996	196/18367	0.178664157342519	0.588467259498787	EGFR/MET/FER/SH2D4A/PPP1R9A/TPRN/PARD3/KCNN4/PTK2/PPP1R3E/ELL/IRS2/HSP90B1/BAD	14
GO:0016859	cis-trans isomerase activity	4/996	41/18367	0.18065606496828	0.58885125674782	FKBP9/PPIC/DEGS1/GSTZ1	4
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/996	41/18367	0.18065606496828	0.58885125674782	COL14A1/COL4A2/COL21A1/COL4A1	4
GO:0048487	beta-tubulin binding	4/996	41/18367	0.18065606496828	0.58885125674782	HDAC6/RACGAP1/IFT74/GABARAPL1	4
GO:0030374	nuclear receptor coactivator activity	5/996	56/18367	0.186006830853335	0.602125205030382	ACTN1/NCOA3/DCAF6/MED24/ENY2	5
GO:0070279	vitamin B6 binding	5/996	56/18367	0.186006830853335	0.602125205030382	GLDC/PSAT1/PDXDC1/ALAS1/SPTLC3	5
GO:0048029	monosaccharide binding	6/996	71/18367	0.186648894558003	0.602134447512461	COLEC12/PLOD2/LMAN1/RPIA/MANBA/BSG	6
GO:0004725	protein tyrosine phosphatase activity	8/996	102/18367	0.188664667557407	0.603077006630416	PTPN14/UBASH3B/PTPRK/DUSP9/PTPRF/DUSP6/DUSP5/DUSP14	8
GO:0019903	protein phosphatase binding	11/996	150/18367	0.191422063124664	0.603077006630416	EGFR/MET/FER/PPP1R9A/PARD3/KCNN4/PTK2/PPP1R3E/IRS2/HSP90B1/BAD	11
GO:0140677	molecular function activator activity	11/996	150/18367	0.191422063124664	0.603077006630416	TOR1AIP2/DNAJB4/PPP1R12B/MMP15/WRNIP1/CCL5/NUPR1/PSAP/DDOST/PDPK1/AZIN1	11
GO:0070325	lipoprotein particle receptor binding	3/996	28/18367	0.192152411768853	0.603077006630416	LRP1/CLTC/HSP90B1	3
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	3/996	28/18367	0.192152411768853	0.603077006630416	KIF16B/WIPI2/PLEKHA5	3
GO:0004467	long-chain fatty acid-CoA ligase activity	2/996	15/18367	0.193983368374752	0.603077006630416	SLC27A2/ACSF2	2
GO:0005452	inorganic anion exchanger activity	2/996	15/18367	0.193983368374752	0.603077006630416	SLC4A2/SLC22A11	2
GO:0016805	dipeptidase activity	2/996	15/18367	0.193983368374752	0.603077006630416	NAALAD2/CPQ	2
GO:0048185	activin binding	2/996	15/18367	0.193983368374752	0.603077006630416	TGFBR3/ACVR2B	2
GO:1901611	phosphatidylglycerol binding	2/996	15/18367	0.193983368374752	0.603077006630416	MME/NME4	2
GO:1904680	peptide transmembrane transporter activity	2/996	15/18367	0.193983368374752	0.603077006630416	GJA1/SLC13A3	2
GO:0008235	metalloexopeptidase activity	6/996	72/18367	0.195007203086326	0.603795207457407	ENPEP/NAALAD2/TFRC/MMP14/MMP15/CPQ	6
GO:0043175	RNA polymerase core enzyme binding	5/996	57/18367	0.195496325132175	0.603795207457407	BRD4/NCOA3/DHX9/WDR43/ZNF326	5
GO:0004197	cysteine-type endopeptidase activity	9/996	119/18367	0.197110422856242	0.606790909577059	CTSV/CTSL/LGMN/USP47/GPAA1/USP14/ATG4C/CAPN7/USP25	9
GO:0015103	inorganic anion transmembrane transporter activity	11/996	152/18367	0.202876116522221	0.617948596277344	SLC6A4/SLC26A2/GABRE/CLDN4/GPR89A/SLC4A2/FXYD3/SLC22A11/MFSD5/CLIC4/LRRC8D	11
GO:0033293	monocarboxylic acid binding	6/996	73/18367	0.203503218304536	0.617948596277344	NR2F2/PPARG/PPARD/RXRA/GSTP1/PSAP	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	10/996	136/18367	0.20362664658014	0.617948596277344	RDH10/HSD17B1/RDH14/IDH1/IMPDH2/GCLM/AKR1B1/HSD17B12/LDHB/HADHB	10
GO:0008028	monocarboxylic acid transmembrane transporter activity	5/996	58/18367	0.2051496411165	0.617948596277344	SLC27A2/SLC16A1/ABCG2/SLC16A12/SLC16A4	5
GO:0004674	protein serine/threonine kinase activity	25/996	386/18367	0.205493630713451	0.617948596277344	EGFR/LTBP1/WNK2/TGFBR3/EIF2AK4/NRK/ACVR2B/PAK6/CAMK2G/BRD4/LATS2/LIMK2/PRKCI/MAP3K7/MAP3K13/PINK1/CDK6/MAP4K4/ATR/PLK2/NEK8/TOP1/RPS6KA4/SRPK1/PDPK1	25
GO:0004033	aldo-keto reductase (NADP) activity	3/996	29/18367	0.206302952072475	0.617948596277344	RDH10/RDH14/AKR1B1	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	3/996	29/18367	0.206302952072475	0.617948596277344	DHCR24/DECR2/AKR1B1	3
GO:0070717	poly-purine tract binding	3/996	29/18367	0.206302952072475	0.617948596277344	RBMS3/RBPMS/DDX1	3
GO:0015297	antiporter activity	7/996	89/18367	0.207753062710584	0.617948596277344	SLC26A2/SLC19A1/SLC4A2/SLC25A4/SLC7A6/SLC35D1/SLC35E1	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	12/996	170/18367	0.212708493824317	0.617948596277344	KDM5B/PLOD2/UTY/ASPH/MICAL3/SQLE/DEGS1/CYP2J2/TET2/P4HB/COQ6/HSPBAP1	12
GO:0003688	DNA replication origin binding	2/996	16/18367	0.214198291655087	0.617948596277344	MCM2/DHX9	2
GO:0005092	GDP-dissociation inhibitor activity	2/996	16/18367	0.214198291655087	0.617948596277344	SH3BP4/CHML	2
GO:0005283	amino acid:sodium symporter activity	2/996	16/18367	0.214198291655087	0.617948596277344	SLC1A3/SLC38A2	2
GO:0015923	mannosidase activity	2/996	16/18367	0.214198291655087	0.617948596277344	MAN2B2/MANBA	2
GO:0016004	phospholipase activator activity	2/996	16/18367	0.214198291655087	0.617948596277344	CCL5/PDPK1	2
GO:0016307	phosphatidylinositol phosphate kinase activity	2/996	16/18367	0.214198291655087	0.617948596277344	PIP5K1A/PIP5K1B	2
GO:0035497	cAMP response element binding	2/996	16/18367	0.214198291655087	0.617948596277344	CREB3L2/CREB3	2
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	2/996	16/18367	0.214198291655087	0.617948596277344	SOCS6/SOCS7	2
GO:0140327	flippase activity	2/996	16/18367	0.214198291655087	0.617948596277344	TMEM30B/ATP10D	2
GO:0001784	phosphotyrosine residue binding	4/996	44/18367	0.214510818452963	0.617948596277344	RASA1/SHB/YES1/BCAR3	4
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	4/996	44/18367	0.214510818452963	0.617948596277344	ALDH7A1/DHTKD1/AKR1B1/HSD17B12	4
GO:0030246	carbohydrate binding	18/996	271/18367	0.219174903281796	0.62945963076662	COLEC12/PLOD2/GAA/GALNT18/LMAN1/AGL/GALNT11/OLR1/CDIPT/PPP1R3E/RPIA/MAN2B2/MANBA/BSG/SIGLEC6/CHID1/GANAB/GUSB	18
GO:0005343	organic acid:sodium symporter activity	3/996	30/18367	0.220678671637642	0.630517527683959	SLC1A3/SLC13A3/SLC38A2	3
GO:0019003	GDP binding	6/996	75/18367	0.220881936449794	0.630517527683959	MRAS/GNAI1/MIEF1/HRAS/RAB31/RAB17	6
GO:0019209	kinase activator activity	8/996	107/18367	0.22427134735474	0.631347016319331	EFNA5/ERBB3/ALS2/CD24/CCL5/TPX2/RICTOR/BCL10	8
GO:0051087	chaperone binding	8/996	107/18367	0.22427134735474	0.631347016319331	LRP2/HLA-B/DNAJB4/SLC25A17/GRN/BIRC5/SCARB2/BAG1	8
GO:1902936	phosphatidylinositol bisphosphate binding	8/996	107/18367	0.22427134735474	0.631347016319331	SCIN/SYT7/KIF16B/WIPI2/PLEKHA5/PARD3/GSN/ANXA2	8
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/996	45/18367	0.226164030750777	0.631347016319331	WEE1/FER/YES1/PTK2	4
GO:0008237	metallopeptidase activity	13/996	190/18367	0.232274307692113	0.631347016319331	ADAMTS1/ENPEP/ADAMTS19/NAALAD2/ADAMTS6/TFRC/MME/MMP14/BRCC3/MMP15/AFG3L2/CPQ/STAMBP	13
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/996	17/18367	0.234592917829967	0.631347016319331	PTPRK/PTPRF	2
GO:0005324	long-chain fatty acid transporter activity	2/996	17/18367	0.234592917829967	0.631347016319331	SLC27A2/SLC2A1	2
GO:0008381	mechanosensitive ion channel activity	2/996	17/18367	0.234592917829967	0.631347016319331	TMEM150C/TMC5	2
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	2/996	17/18367	0.234592917829967	0.631347016319331	BCL2L13/BAD	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/996	17/18367	0.234592917829967	0.631347016319331	PTPRK/PTPRF	2
GO:0030169	low-density lipoprotein particle binding	2/996	17/18367	0.234592917829967	0.631347016319331	COLEC12/LDLR	2
GO:0042625	ATPase-coupled ion transmembrane transporter activity	2/996	17/18367	0.234592917829967	0.631347016319331	ATP6V1H/ATP6V1C2	2
GO:0043024	ribosomal small subunit binding	2/996	17/18367	0.234592917829967	0.631347016319331	ABCE1/NME1	2
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	2/996	17/18367	0.234592917829967	0.631347016319331	ATP6V1H/ATP6V1C2	2
GO:0046961	proton-transporting ATPase activity, rotational mechanism	2/996	17/18367	0.234592917829967	0.631347016319331	ATP6V1H/ATP6V1C2	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/996	17/18367	0.234592917829967	0.631347016319331	B3GNT5/B3GNT3	2
GO:0070064	proline-rich region binding	2/996	17/18367	0.234592917829967	0.631347016319331	YAP1/CCND1	2
GO:0008157	protein phosphatase 1 binding	3/996	31/18367	0.235247136654018	0.631347016319331	FER/PPP1R9A/PPP1R3E	3
GO:0042910	xenobiotic transmembrane transporter activity	3/996	31/18367	0.235247136654018	0.631347016319331	SLC19A1/ABCG2/SLC2A1	3
GO:0043015	gamma-tubulin binding	3/996	31/18367	0.235247136654018	0.631347016319331	RACGAP1/BRCA2/NME1	3
GO:0140318	protein transporter activity	3/996	31/18367	0.235247136654018	0.631347016319331	LRP2/IGF1R/SEC63	3
GO:0003724	RNA helicase activity	6/996	77/18367	0.238731078911437	0.638876921405038	AQR/DHX32/DDX3Y/DHX9/DHX15/DDX1	6
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	20/996	310/18367	0.241969309880955	0.645708469993937	IRX2/NFE2L3/HIC2/BHLHE41/PEG3/GLIS3/ZFHX3/PPARG/ZIM2/TFAP2C/TFAP2A/PPARD/TBX3/CC2D1B/ZNF440/ZNF439/NR2F6/SMAD5/ZNF281/ZNF750	20
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4/996	47/18367	0.249923073530358	0.659056173421025	DUSP9/DUSP6/DUSP5/DUSP14	4
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/996	47/18367	0.249923073530358	0.659056173421025	ATP2B1/ATP13A3/ATP6V1H/ATP6V1C2	4
GO:0140030	modification-dependent protein binding	11/996	160/18367	0.251430339095913	0.659056173421025	MORC4/BRD4/SPIN1/AGL/BRCC3/TAB3/CBX4/HDAC6/TRIM24/RAD23B/CBX5	11
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/996	18/18367	0.255088405711952	0.659056173421025	HSD17B1/HSD17B12	2
GO:0046527	glucosyltransferase activity	2/996	18/18367	0.255088405711952	0.659056173421025	ALG6/UGGT2	2
GO:0046624	sphingolipid transporter activity	2/996	18/18367	0.255088405711952	0.659056173421025	PLEKHA8/ATP10D	2
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/996	18/18367	0.255088405711952	0.659056173421025	GCLM/AKR1B1	2
GO:0060229	lipase activator activity	2/996	18/18367	0.255088405711952	0.659056173421025	CCL5/PDPK1	2
GO:0070122	isopeptidase activity	2/996	18/18367	0.255088405711952	0.659056173421025	BRCC3/STAMBP	2
GO:0015293	symporter activity	10/996	144/18367	0.255250016582109	0.659056173421025	SLC6A4/SLC16A1/SLC16A12/SLC1A3/SLC13A3/SLC1A5/SLC11A2/SLC16A4/SLC38A2/SLC5A3	10
GO:0016798	hydrolase activity, acting on glycosyl bonds	10/996	144/18367	0.255250016582109	0.659056173421025	NAGLU/MOGS/GAA/AGL/MAN2B2/MANBA/FUCA1/GANAB/NEU1/GUSB	10
GO:0001217	DNA-binding transcription repressor activity	20/996	313/18367	0.255366776325556	0.659056173421025	IRX2/NFE2L3/HIC2/BHLHE41/PEG3/GLIS3/ZFHX3/PPARG/ZIM2/TFAP2C/TFAP2A/PPARD/TBX3/CC2D1B/ZNF440/ZNF439/NR2F6/SMAD5/ZNF281/ZNF750	20
GO:0008186	ATP-dependent activity, acting on RNA	6/996	79/18367	0.256995319185301	0.659644661233115	AQR/DHX32/DDX3Y/DHX9/DHX15/DDX1	6
GO:0046332	SMAD binding	6/996	79/18367	0.256995319185301	0.659644661233115	TGFBR3/PPARG/DAB2/AXIN2/FERMT2/SMAD5	6
GO:0004527	exonuclease activity	6/996	80/18367	0.266265580159134	0.681582001385608	APEX2/REXO4/ERI2/FEN1/RAD50/DDX1	6
GO:0004843	thiol-dependent deubiquitinase	8/996	113/18367	0.26987381225408	0.688680804670784	USP43/BRCC3/USP27X/USP47/STAMBP/USP14/UCHL3/USP25	8
GO:0004896	cytokine receptor activity	7/996	97/18367	0.273181415068898	0.688680804670784	LIFR/PRLR/CSF3R/CSF2RA/IL6ST/IL10RB/IL2RG	7
GO:0000339	RNA cap binding	2/996	19/18367	0.275613920676554	0.688680804670784	CYFIP1/NCBP3	2
GO:0004129	cytochrome-c oxidase activity	2/996	19/18367	0.275613920676554	0.688680804670784	COX6A1/SURF1	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/996	19/18367	0.275613920676554	0.688680804670784	GALNT18/GALNT11	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/996	19/18367	0.275613920676554	0.688680804670784	SLC6A4/SLC29A1	2
GO:0035613	RNA stem-loop binding	2/996	19/18367	0.275613920676554	0.688680804670784	MYH10/DHX9	2
GO:0052742	phosphatidylinositol kinase activity	2/996	19/18367	0.275613920676554	0.688680804670784	PIP5K1A/PIP5K1B	2
GO:0035591	signaling adaptor activity	6/996	81/18367	0.275618538599666	0.688680804670784	SHANK2/SORBS1/DLG5/SPATA2/MPP7/EPS8	6
GO:0101005	deubiquitinase activity	8/996	114/18367	0.277724802174792	0.692107840340354	USP43/BRCC3/USP27X/USP47/STAMBP/USP14/UCHL3/USP25	8
GO:0015020	glucuronosyltransferase activity	3/996	34/18367	0.279800624767887	0.693611022450919	CHPF/B4GAT1/EXT2	3
GO:0016831	carboxy-lyase activity	3/996	34/18367	0.279800624767887	0.693611022450919	PISD/PDXDC1/AZIN1	3
GO:0019842	vitamin binding	10/996	148/18367	0.282578276928917	0.698658102013229	GLDC/PLOD2/SLC19A1/PSAT1/FOLR1/DHTKD1/PDXDC1/ALAS1/OPN3/SPTLC3	10
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/996	50/18367	0.286448933585469	0.704529753100552	CDKN1C/CCND1/CCNE1/CCNA2	4
GO:0030159	signaling receptor complex adaptor activity	4/996	50/18367	0.286448933585469	0.704529753100552	SHANK2/SORBS1/DLG5/SPATA2	4
GO:0001972	retinoic acid binding	2/996	20/18367	0.29610599958076	0.706575839790882	NR2F2/RXRA	2
GO:0003756	protein disulfide isomerase activity	2/996	20/18367	0.29610599958076	0.706575839790882	CRELD1/P4HB	2
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	2/996	20/18367	0.29610599958076	0.706575839790882	ATP6V1H/ATP6V1C2	2
GO:0016408	C-acyltransferase activity	2/996	20/18367	0.29610599958076	0.706575839790882	HADHB/SPTLC3	2
GO:0016505	peptidase activator activity involved in apoptotic process	2/996	20/18367	0.29610599958076	0.706575839790882	BCL2L13/BAD	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/996	20/18367	0.29610599958076	0.706575839790882	COX6A1/SURF1	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/996	20/18367	0.29610599958076	0.706575839790882	CRELD1/P4HB	2
GO:0031681	G-protein beta-subunit binding	2/996	20/18367	0.29610599958076	0.706575839790882	GNG12/GNG5	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/996	20/18367	0.29610599958076	0.706575839790882	SOCS6/SOCS7	2
GO:0070300	phosphatidic acid binding	2/996	20/18367	0.29610599958076	0.706575839790882	MICALL1/PACSIN2	2
GO:0097001	ceramide binding	2/996	20/18367	0.29610599958076	0.706575839790882	PLEKHA8/PSAP	2
GO:0005516	calmodulin binding	13/996	201/18367	0.296281801186198	0.706575839790882	EGFR/MYH10/SYT7/MYO7A/TRPV6/ASPM/CAMK2G/CALD1/WFS1/ATP2B1/TJP1/KCNN4/CAMSAP2	13
GO:0005496	steroid binding	7/996	100/18367	0.2990106729688	0.711282964486388	ESRRG/OSBPL10/PROM2/HSD17B1/ESRRA/INSIG1/SCARB2	7
GO:0030295	protein kinase activator activity	7/996	101/18367	0.30773550759337	0.728471981962158	EFNA5/ERBB3/ALS2/CD24/CCL5/TPX2/RICTOR	7
GO:0016887	ATP hydrolysis activity	17/996	272/18367	0.30778327900312	0.728471981962158	KIF16B/CHD7/MCM2/ATP2B1/RHOBTB3/WRNIP1/ATP13A3/NAV2/RAD54L2/AQR/DHX32/ATP10D/DDX3Y/ATP6V1H/DHX9/DHX15/DDX1	17
GO:0016597	amino acid binding	4/996	52/18367	0.311207236139765	0.73472986577358	GLDC/SLC1A3/GSS/ASS1	4
GO:0005243	gap junction channel activity	2/996	21/18367	0.3165079609067	0.739827541374966	GJA1/GJA5	2
GO:0070577	lysine-acetylated histone binding	2/996	21/18367	0.3165079609067	0.739827541374966	BRD4/TRIM24	2
GO:0140033	acetylation-dependent protein binding	2/996	21/18367	0.3165079609067	0.739827541374966	BRD4/TRIM24	2
GO:1990381	ubiquitin-specific protease binding	2/996	21/18367	0.3165079609067	0.739827541374966	SPATA2/CLTC	2
GO:0019001	guanyl nucleotide binding	24/996	398/18367	0.324604623631467	0.748598162178508	SLC19A1/GNA12/RASL11B/MRAS/GNAI1/GNA11/MIEF1/HRAS/RHOBTB3/ARL4A/RAB38/TGM2/RAB13/RHOBTB1/RTCB/RAB31/ARHGAP5/ARL5B/RAB17/LSG1/EHD3/RRAGA/NME1/RND3	24
GO:0032561	guanyl ribonucleotide binding	24/996	398/18367	0.324604623631467	0.748598162178508	SLC19A1/GNA12/RASL11B/MRAS/GNAI1/GNA11/MIEF1/HRAS/RHOBTB3/ARL4A/RAB38/TGM2/RAB13/RHOBTB1/RTCB/RAB31/ARHGAP5/ARL5B/RAB17/LSG1/EHD3/RRAGA/NME1/RND3	24
GO:0005085	guanyl-nucleotide exchange factor activity	14/996	223/18367	0.324897291454074	0.748598162178508	NET1/ADRB1/PLEKHG4B/SWAP70/ANKRD27/DOCK1/ALS2/DOCK9/ARHGEF11/BCAR3/EPS8L2/CYTH3/VAV3/DENND5A	14
GO:0015035	protein-disulfide reductase activity	3/996	37/18367	0.325028289098737	0.748598162178508	P4HB/TXNRD2/TXNRD1	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3/996	37/18367	0.325028289098737	0.748598162178508	ALDH7A1/AKR1B1/HSD17B12	3
GO:0043531	ADP binding	3/996	37/18367	0.325028289098737	0.748598162178508	MYH10/MYO7A/MIEF1	3
GO:0001098	basal transcription machinery binding	5/996	70/18367	0.330094247055223	0.755325558068587	BRD4/NCOA3/DHX9/WDR43/ZNF326	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/996	70/18367	0.330094247055223	0.755325558068587	BRD4/NCOA3/DHX9/WDR43/ZNF326	5
GO:0005253	anion channel activity	6/996	87/18367	0.333079808133151	0.755325558068587	GABRE/CLDN4/GPR89A/FXYD3/CLIC4/LRRC8D	6
GO:0005544	calcium-dependent phospholipid binding	4/996	54/18367	0.336151858387346	0.755325558068587	SYT7/ANXA5/ANXA2/ANXA3	4
GO:0008408	3'-5' exonuclease activity	4/996	54/18367	0.336151858387346	0.755325558068587	APEX2/REXO4/ERI2/RAD50	4
GO:0005355	glucose transmembrane transporter activity	2/996	22/18367	0.336769357100644	0.755325558068587	SLC2A1/SLC5A3	2
GO:0005416	amino acid:cation symporter activity	2/996	22/18367	0.336769357100644	0.755325558068587	SLC1A3/SLC38A2	2
GO:0015149	hexose transmembrane transporter activity	2/996	22/18367	0.336769357100644	0.755325558068587	SLC2A1/SLC5A3	2
GO:0015645	fatty acid ligase activity	2/996	22/18367	0.336769357100644	0.755325558068587	SLC27A2/ACSF2	2
GO:0030742	GTP-dependent protein binding	2/996	22/18367	0.336769357100644	0.755325558068587	MRAS/RAB38	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/996	22/18367	0.336769357100644	0.755325558068587	BIRC5/PRDX5	2
GO:0005501	retinoid binding	3/996	38/18367	0.340132834134247	0.759253861977396	NR2F2/RXRA/OPN3	3
GO:0019840	isoprenoid binding	3/996	38/18367	0.340132834134247	0.759253861977396	NR2F2/RXRA/OPN3	3
GO:0051082	unfolded protein binding	8/996	122/18367	0.342379389767104	0.762461903452984	SERPINH1/LMAN1/UGGT2/HEATR3/DNAJB4/AFG3L2/HSP90B1/SIL1	8
GO:0051117	ATPase binding	6/996	89/18367	0.352579539283367	0.776324316925579	EGFR/PELP1/TOR1AIP2/WFS1/UBE4B/USP25	6
GO:0061659	ubiquitin-like protein ligase activity	19/996	316/18367	0.354435777584617	0.776324316925579	DTX4/RNF43/TRIML2/SIAH1/ZNRF3/UBR3/TRIM6/RNF128/CBX4/MDM2/UBE4B/TRIM24/ZNF451/TRIM37/RANBP2/RNF114/MED24/TRIM27/HUWE1	19
GO:0004402	histone acetyltransferase activity	3/996	39/18367	0.355212748362389	0.776324316925579	NCOA3/BRCA2/MED24	3
GO:0005504	fatty acid binding	3/996	39/18367	0.355212748362389	0.776324316925579	PPARG/PPARD/GSTP1	3
GO:0050997	quaternary ammonium group binding	3/996	39/18367	0.355212748362389	0.776324316925579	NF1/DHTKD1/SCARB2	3
GO:0004529	exodeoxyribonuclease activity	2/996	23/18367	0.356845466272586	0.776324316925579	APEX2/FEN1	2
GO:0008483	transaminase activity	2/996	23/18367	0.356845466272586	0.776324316925579	PSAT1/GFPT1	2
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/996	23/18367	0.356845466272586	0.776324316925579	APEX2/FEN1	2
GO:0017025	TBP-class protein binding	2/996	23/18367	0.356845466272586	0.776324316925579	CAND1/TAF11	2
GO:0050750	low-density lipoprotein particle receptor binding	2/996	23/18367	0.356845466272586	0.776324316925579	CLTC/HSP90B1	2
GO:0045309	protein phosphorylated amino acid binding	4/996	56/18367	0.361170268091087	0.783329812383081	RASA1/SHB/YES1/BCAR3	4
GO:0015370	solute:sodium symporter activity	5/996	73/18367	0.362761520309657	0.783329812383081	SLC6A4/SLC1A3/SLC13A3/SLC38A2/SLC5A3	5
GO:0070063	RNA polymerase binding	5/996	73/18367	0.362761520309657	0.783329812383081	BRD4/NCOA3/DHX9/WDR43/ZNF326	5
GO:0019783	ubiquitin-like protein-specific protease activity	8/996	125/18367	0.367201462758336	0.783329812383081	USP43/BRCC3/USP27X/USP47/STAMBP/USP14/UCHL3/USP25	8
GO:0003925	G protein activity	3/996	40/18367	0.370246609140534	0.783329812383081	RASL11B/MRAS/HRAS	3
GO:0017080	sodium channel regulator activity	3/996	40/18367	0.370246609140534	0.783329812383081	PRSS8/FXYD3/PKP2	3
GO:0043014	alpha-tubulin binding	3/996	40/18367	0.370246609140534	0.783329812383081	HDAC6/RACGAP1/BEX4	3
GO:0003924	GTPase activity	20/996	337/18367	0.371076911237436	0.783329812383081	GNA12/RASA1/RASL11B/MRAS/GNAI1/GNA11/HRAS/RHOBTB3/ARL4A/RAB38/RAB13/RHOBTB1/RAB31/ARHGAP5/ARL5B/RAB17/LSG1/GNG5/RRAGA/RND3	20
GO:0004536	deoxyribonuclease activity	4/996	57/18367	0.373673961899307	0.783329812383081	APEX2/FEN1/NME1/RAD50	4
GO:0005548	phospholipid transporter activity	4/996	57/18367	0.373673961899307	0.783329812383081	OSBPL10/PLEKHA8/TMEM30B/TRIAP1	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	4/996	57/18367	0.373673961899307	0.783329812383081	P4HB/MSRB2/TXNRD2/TXNRD1	4
GO:0008242	omega peptidase activity	8/996	126/18367	0.375513098858821	0.783329812383081	USP43/BRCC3/USP27X/USP47/STAMBP/USP14/UCHL3/USP25	8
GO:0009055	electron transfer activity	8/996	126/18367	0.375513098858821	0.783329812383081	GLDC/ASPH/DEGS1/CYC1/CYBA/COX6A1/AKR1B1/SURF1	8
GO:0004622	lysophospholipase activity	2/996	24/18367	0.376696820604603	0.783329812383081	ABHD12/LYPLA1	2
GO:0008171	O-methyltransferase activity	2/996	24/18367	0.376696820604603	0.783329812383081	COMT/LCMT1	2
GO:0010857	calcium-dependent protein kinase activity	2/996	24/18367	0.376696820604603	0.783329812383081	PRKCI/PINK1	2
GO:0015145	monosaccharide transmembrane transporter activity	2/996	24/18367	0.376696820604603	0.783329812383081	SLC2A1/SLC5A3	2
GO:0016769	transferase activity, transferring nitrogenous groups	2/996	24/18367	0.376696820604603	0.783329812383081	PSAT1/GFPT1	2
GO:0043495	protein-membrane adaptor activity	2/996	24/18367	0.376696820604603	0.783329812383081	EPB41L3/NUP153	2
GO:0120014	phospholipid transfer activity	2/996	24/18367	0.376696820604603	0.783329812383081	PLEKHA8/TRIAP1	2
GO:0042626	ATPase-coupled transmembrane transporter activity	7/996	109/18367	0.378857890934928	0.786088399252648	SLC26A2/ABCG2/ATP2B1/ATP13A3/ATP6V1H/ATP6V1C2/ABCB8	7
GO:0042826	histone deacetylase binding	8/996	127/18367	0.383836984086829	0.788195438159261	BHLHE41/MAGEA8/MTA3/GLI3/CCND1/HDAC6/BEX4/TOP2A	8
GO:0061733	peptide-lysine-N-acetyltransferase activity	3/996	41/18367	0.385214283680449	0.788195438159261	NCOA3/BRCA2/MED24	3
GO:0005525	GTP binding	22/996	377/18367	0.39226706514278	0.788195438159261	GNA12/RASL11B/MRAS/GNAI1/GNA11/HRAS/RHOBTB3/ARL4A/RAB38/TGM2/RAB13/RHOBTB1/RTCB/RAB31/ARHGAP5/ARL5B/RAB17/LSG1/EHD3/RRAGA/NME1/RND3	22
GO:0008266	poly(U) RNA binding	2/996	25/18367	0.396288768987585	0.788195438159261	RBMS3/MSI2	2
GO:0030247	polysaccharide binding	2/996	25/18367	0.396288768987585	0.788195438159261	AGL/PPP1R3E	2
GO:0004222	metalloendopeptidase activity	7/996	111/18367	0.39682105314339	0.788195438159261	ADAMTS1/ADAMTS19/ADAMTS6/MME/MMP14/MMP15/AFG3L2	7
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	26/996	450/18367	0.397657017809375	0.788195438159261	ESRRG/PBX1/ETV5/GLIS3/ISL1/ELF3/SOX4/DLX3/NFIB/EPAS1/ZFAT/TFAP2C/DLX5/TFAP2A/NFAT5/FOXO4/CEBPA/MAFG/TBX3/CREB3L2/CREB3/TFDP2/FOXC1/KLF5/ZNF750/RBPJ	26
GO:0008307	structural constituent of muscle	3/996	42/18367	0.400096911997249	0.788195438159261	DAG1/ASPH/CSRP2	3
GO:0015036	disulfide oxidoreductase activity	3/996	42/18367	0.400096911997249	0.788195438159261	P4HB/TXNRD2/TXNRD1	3
GO:0051539	4 iron, 4 sulfur cluster binding	3/996	42/18367	0.400096911997249	0.788195438159261	ACO1/ABCE1/PPAT	3
GO:0016410	N-acyltransferase activity	6/996	94/18367	0.401582804974689	0.788195438159261	HGSNAT/TGM2/NCOA3/BRCA2/MED24/ALAS1	6
GO:0015078	proton transmembrane transporter activity	8/996	130/18367	0.408843715869889	0.788195438159261	ATP6V1B1/SLC25A4/CYC1/SLC11A2/ATP6V1H/COX6A1/ATP6V1C2/SURF1	8
GO:0032934	sterol binding	4/996	60/18367	0.41101535753368	0.788195438159261	OSBPL10/PROM2/INSIG1/SCARB2	4
GO:0004180	carboxypeptidase activity	3/996	43/18367	0.414876884694992	0.788195438159261	NAALAD2/CPQ/CPVL	3
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	3/996	43/18367	0.414876884694992	0.788195438159261	MICAL3/SQLE/COQ6	3
GO:0008198	ferrous iron binding	2/996	26/18367	0.415591071566591	0.788195438159261	TET2/CDO1	2
GO:0001221	transcription coregulator binding	5/996	78/18367	0.417242038635285	0.788195438159261	EPAS1/HDAC6/PPARD/TFAM/VGLL4	5
GO:0043621	protein self-association	4/996	61/18367	0.42336784780078	0.788195438159261	PPARG/SLC2A1/CCL5/BCL10	4
GO:0001216	DNA-binding transcription activator activity	26/996	456/18367	0.424472738465476	0.788195438159261	ESRRG/PBX1/ETV5/GLIS3/ISL1/ELF3/SOX4/DLX3/NFIB/EPAS1/ZFAT/TFAP2C/DLX5/TFAP2A/NFAT5/FOXO4/CEBPA/MAFG/TBX3/CREB3L2/CREB3/TFDP2/FOXC1/KLF5/ZNF750/RBPJ	26
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/996	10/18367	0.427461214513109	0.788195438159261	RAD50	1
GO:0004465	lipoprotein lipase activity	1/996	10/18367	0.427461214513109	0.788195438159261	PNPLA2	1
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/996	10/18367	0.427461214513109	0.788195438159261	FEN1	1
GO:0004955	prostaglandin receptor activity	1/996	10/18367	0.427461214513109	0.788195438159261	PPARG	1
GO:0005384	manganese ion transmembrane transporter activity	1/996	10/18367	0.427461214513109	0.788195438159261	SLC11A2	1
GO:0015643	toxic substance binding	1/996	10/18367	0.427461214513109	0.788195438159261	ASS1	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/996	10/18367	0.427461214513109	0.788195438159261	CYBA	1
GO:0016595	glutamate binding	1/996	10/18367	0.427461214513109	0.788195438159261	SLC1A3	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1/996	10/18367	0.427461214513109	0.788195438159261	PPOX	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/996	10/18367	0.427461214513109	0.788195438159261	CYB5R1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/996	10/18367	0.427461214513109	0.788195438159261	DEGS1	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/996	10/18367	0.427461214513109	0.788195438159261	PMM2	1
GO:0017002	activin-activated receptor activity	1/996	10/18367	0.427461214513109	0.788195438159261	ACVR2B	1
GO:0019531	oxalate transmembrane transporter activity	1/996	10/18367	0.427461214513109	0.788195438159261	SLC26A2	1
GO:0019869	chloride channel inhibitor activity	1/996	10/18367	0.427461214513109	0.788195438159261	WNK2	1
GO:0030957	Tat protein binding	1/996	10/18367	0.427461214513109	0.788195438159261	GABARAPL1	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/996	10/18367	0.427461214513109	0.788195438159261	HDAC6	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/996	10/18367	0.427461214513109	0.788195438159261	SLC27A2	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/996	10/18367	0.427461214513109	0.788195438159261	HDAC6	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/996	10/18367	0.427461214513109	0.788195438159261	SYNJ1	1
GO:0034713	type I transforming growth factor beta receptor binding	1/996	10/18367	0.427461214513109	0.788195438159261	FERMT2	1
GO:0035374	chondroitin sulfate binding	1/996	10/18367	0.427461214513109	0.788195438159261	PTN	1
GO:0043208	glycosphingolipid binding	1/996	10/18367	0.427461214513109	0.788195438159261	PSAP	1
GO:0045294	alpha-catenin binding	1/996	10/18367	0.427461214513109	0.788195438159261	PKP2	1
GO:0045503	dynein light chain binding	1/996	10/18367	0.427461214513109	0.788195438159261	HOOK3	1
GO:0046030	inositol trisphosphate phosphatase activity	1/996	10/18367	0.427461214513109	0.788195438159261	SYNJ1	1
GO:0047760	butyrate-CoA ligase activity	1/996	10/18367	0.427461214513109	0.788195438159261	ACSF2	1
GO:0048256	flap endonuclease activity	1/996	10/18367	0.427461214513109	0.788195438159261	FEN1	1
GO:0050786	RAGE receptor binding	1/996	10/18367	0.427461214513109	0.788195438159261	S100A4	1
GO:0051880	G-quadruplex DNA binding	1/996	10/18367	0.427461214513109	0.788195438159261	RAD50	1
GO:0070008	serine-type exopeptidase activity	1/996	10/18367	0.427461214513109	0.788195438159261	CPVL	1
GO:0070016	armadillo repeat domain binding	1/996	10/18367	0.427461214513109	0.788195438159261	TCF7L2	1
GO:0070567	cytidylyltransferase activity	1/996	10/18367	0.427461214513109	0.788195438159261	CDS1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/996	10/18367	0.427461214513109	0.788195438159261	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/996	10/18367	0.427461214513109	0.788195438159261	PLEKHA8	1
GO:0019887	protein kinase regulator activity	12/996	204/18367	0.428372314815356	0.788195438159261	EFNA5/ERBB3/ALS2/CDKN1C/CCND1/CD24/CCL5/PKIB/TPX2/RICTOR/CCNE1/CCNA2	12
GO:0044325	transmembrane transporter binding	8/996	133/18367	0.433824690474908	0.788195438159261	TCAF1/PPP1R9A/PRKCSH/YES1/ACTN1/PKP2/ANK3/SLC5A3	8
GO:0001671	ATPase activator activity	2/996	27/18367	0.434577524025647	0.788195438159261	TOR1AIP2/DNAJB4	2
GO:0004190	aspartic-type endopeptidase activity	2/996	27/18367	0.434577524025647	0.788195438159261	SPPL2B/BACE2	2
GO:0008139	nuclear localization sequence binding	2/996	27/18367	0.434577524025647	0.788195438159261	TNPO1/NUP153	2
GO:0016866	intramolecular transferase activity	2/996	27/18367	0.434577524025647	0.788195438159261	CYP2J2/PMM2	2
GO:0035255	ionotropic glutamate receptor binding	2/996	27/18367	0.434577524025647	0.788195438159261	SHANK2/FLOT2	2
GO:0048027	mRNA 5'-UTR binding	2/996	27/18367	0.434577524025647	0.788195438159261	MYH10/IGF2BP3	2
GO:0051119	sugar transmembrane transporter activity	2/996	27/18367	0.434577524025647	0.788195438159261	SLC2A1/SLC5A3	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/996	27/18367	0.434577524025647	0.788195438159261	TMEM30B/ATP10D	2
GO:0048156	tau protein binding	3/996	45/18367	0.444064515344128	0.788195438159261	HDAC6/LGMN/PPP2CB	3
GO:0004629	phospholipase C activity	2/996	28/18367	0.453225609583862	0.788195438159261	NOTUM/CCL5	2
GO:0008187	poly-pyrimidine tract binding	2/996	28/18367	0.453225609583862	0.788195438159261	RBMS3/MSI2	2
GO:0017056	structural constituent of nuclear pore	2/996	28/18367	0.453225609583862	0.788195438159261	NUP153/UPF3A	2
GO:0046875	ephrin receptor binding	2/996	28/18367	0.453225609583862	0.788195438159261	EFNA5/EFNA1	2
GO:0070001	aspartic-type peptidase activity	2/996	28/18367	0.453225609583862	0.788195438159261	SPPL2B/BACE2	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/996	28/18367	0.453225609583862	0.788195438159261	ANKRD9/FEM1A	2
GO:0140296	general transcription initiation factor binding	3/996	46/18367	0.458442950333396	0.788195438159261	CAND1/TAF11/BCL10	3
GO:0002162	dystroglycan binding	1/996	11/18367	0.458525583982245	0.788195438159261	DAG1	1
GO:0004954	prostanoid receptor activity	1/996	11/18367	0.458525583982245	0.788195438159261	PPARG	1
GO:0008503	benzodiazepine receptor activity	1/996	11/18367	0.458525583982245	0.788195438159261	GABRE	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/996	11/18367	0.458525583982245	0.788195438159261	PKIB	1
GO:0010485	H4 histone acetyltransferase activity	1/996	11/18367	0.458525583982245	0.788195438159261	BRCA2	1
GO:0015378	sodium:chloride symporter activity	1/996	11/18367	0.458525583982245	0.788195438159261	SLC6A4	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/996	11/18367	0.458525583982245	0.788195438159261	P4HB	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/996	11/18367	0.458525583982245	0.788195438159261	HSD17B1	1
GO:0031996	thioesterase binding	1/996	11/18367	0.458525583982245	0.788195438159261	TRAF4	1
GO:0032404	mismatch repair complex binding	1/996	11/18367	0.458525583982245	0.788195438159261	ATR	1
GO:0035197	siRNA binding	1/996	11/18367	0.458525583982245	0.788195438159261	DHX9	1
GO:0035251	UDP-glucosyltransferase activity	1/996	11/18367	0.458525583982245	0.788195438159261	UGGT2	1
GO:0043522	leucine zipper domain binding	1/996	11/18367	0.458525583982245	0.788195438159261	PAWR	1
GO:0043560	insulin receptor substrate binding	1/996	11/18367	0.458525583982245	0.788195438159261	IGF1R	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/996	11/18367	0.458525583982245	0.788195438159261	DHX9	1
GO:0047676	arachidonate-CoA ligase activity	1/996	11/18367	0.458525583982245	0.788195438159261	SLC27A2	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/996	11/18367	0.458525583982245	0.788195438159261	SYNJ1	1
GO:0097157	pre-mRNA intronic binding	1/996	11/18367	0.458525583982245	0.788195438159261	TARDBP	1
GO:0097371	MDM2/MDM4 family protein binding	1/996	11/18367	0.458525583982245	0.788195438159261	PSME3	1
GO:0099186	structural constituent of postsynapse	1/996	11/18367	0.458525583982245	0.788195438159261	ACTN1	1
GO:1901474	azole transmembrane transporter activity	1/996	11/18367	0.458525583982245	0.788195438159261	SLC19A3	1
GO:1990459	transferrin receptor binding	1/996	11/18367	0.458525583982245	0.788195438159261	SNX4	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	5/996	82/18367	0.460280761986253	0.789771362096631	SCIN/SYT7/PARD3/GSN/ANXA2	5
GO:0032452	histone demethylase activity	2/996	29/18367	0.471516176806928	0.798863738403104	KDM5B/UTY	2
GO:0033612	receptor serine/threonine kinase binding	2/996	29/18367	0.471516176806928	0.798863738403104	BMP7/MDM2	2
GO:0035250	UDP-galactosyltransferase activity	2/996	29/18367	0.471516176806928	0.798863738403104	B3GNT5/B3GNT3	2
GO:0046625	sphingolipid binding	2/996	29/18367	0.471516176806928	0.798863738403104	PLEKHA8/PSAP	2
GO:0051059	NF-kappaB binding	2/996	29/18367	0.471516176806928	0.798863738403104	PPARD/BCL10	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/996	29/18367	0.471516176806928	0.798863738403104	PLEKHA8/PLEKHA5	2
GO:0140457	protein demethylase activity	2/996	29/18367	0.471516176806928	0.798863738403104	KDM5B/UTY	2
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/996	12/18367	0.4879060872702	0.803216061423499	APEX2	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/996	12/18367	0.4879060872702	0.803216061423499	AKR1B1	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/996	12/18367	0.4879060872702	0.803216061423499	CDKN1C	1
GO:0005165	neurotrophin receptor binding	1/996	12/18367	0.4879060872702	0.803216061423499	EFNA5	1
GO:0008174	mRNA methyltransferase activity	1/996	12/18367	0.4879060872702	0.803216061423499	METTL3	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/996	12/18367	0.4879060872702	0.803216061423499	APEX2	1
GO:0015166	polyol transmembrane transporter activity	1/996	12/18367	0.4879060872702	0.803216061423499	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/996	12/18367	0.4879060872702	0.803216061423499	KCNN4	1
GO:0031543	peptidyl-proline dioxygenase activity	1/996	12/18367	0.4879060872702	0.803216061423499	P4HB	1
GO:0034452	dynactin binding	1/996	12/18367	0.4879060872702	0.803216061423499	HOOK3	1
GO:0042975	peroxisome proliferator activated receptor binding	1/996	12/18367	0.4879060872702	0.803216061423499	MDM2	1
GO:0043047	single-stranded telomeric DNA binding	1/996	12/18367	0.4879060872702	0.803216061423499	RAD50	1
GO:0043176	amine binding	1/996	12/18367	0.4879060872702	0.803216061423499	SLC6A4	1
GO:0046790	virion binding	1/996	12/18367	0.4879060872702	0.803216061423499	ANXA2	1
GO:0051378	serotonin binding	1/996	12/18367	0.4879060872702	0.803216061423499	SLC6A4	1
GO:0106310	protein serine kinase activity	20/996	360/18367	0.488586381687165	0.803216061423499	WNK2/EIF2AK4/NRK/PAK6/CAMK2G/LATS2/LIMK2/PRKCI/MAP3K7/MAP3K13/PINK1/CDK6/NEK9/MAP4K4/ATR/PLK2/NEK8/RPS6KA4/SRPK1/PDPK1	20
GO:0022829	wide pore channel activity	2/996	30/18367	0.489433141461877	0.803216061423499	GJA1/GJA5	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/996	30/18367	0.489433141461877	0.803216061423499	HSD17B1/HSD17B12	2
GO:0015294	solute:cation symporter activity	6/996	104/18367	0.498159778589671	0.805611386120865	SLC6A4/SLC1A3/SLC13A3/SLC11A2/SLC38A2/SLC5A3	6
GO:0034212	peptide N-acetyltransferase activity	3/996	49/18367	0.500564999456085	0.805611386120865	NCOA3/BRCA2/MED24	3
GO:0042562	hormone binding	5/996	86/18367	0.502351495798881	0.805611386120865	LRP2/EGFR/PRLR/IGF1R/SLC40A1	5
GO:0000146	microfilament motor activity	2/996	31/18367	0.50696321075897	0.805611386120865	MYH10/MYO7A	2
GO:0005164	tumor necrosis factor receptor binding	2/996	31/18367	0.50696321075897	0.805611386120865	TRAF4/TRIM37	2
GO:0016411	acylglycerol O-acyltransferase activity	2/996	31/18367	0.50696321075897	0.805611386120865	AGPAT1/PNPLA2	2
GO:0031210	phosphatidylcholine binding	2/996	31/18367	0.50696321075897	0.805611386120865	NF1/SCARB2	2
GO:0071813	lipoprotein particle binding	2/996	31/18367	0.50696321075897	0.805611386120865	COLEC12/LDLR	2
GO:0071814	protein-lipid complex binding	2/996	31/18367	0.50696321075897	0.805611386120865	COLEC12/LDLR	2
GO:0003684	damaged DNA binding	4/996	68/18367	0.507495329404669	0.805611386120865	DDB1/POLQ/FEN1/RAD23B	4
GO:0008080	N-acetyltransferase activity	4/996	68/18367	0.507495329404669	0.805611386120865	HGSNAT/NCOA3/BRCA2/MED24	4
GO:0019843	rRNA binding	4/996	68/18367	0.507495329404669	0.805611386120865	RPS4Y1/RPF2/MDM2/TST	4
GO:0051536	iron-sulfur cluster binding	4/996	68/18367	0.507495329404669	0.805611386120865	ACO1/ABCE1/PPAT/KIF4A	4
GO:0051540	metal cluster binding	4/996	68/18367	0.507495329404669	0.805611386120865	ACO1/ABCE1/PPAT/KIF4A	4
GO:0046982	protein heterodimerization activity	18/996	328/18367	0.513997187118399	0.805611386120865	TENM3/ADRB1/BHLHE41/EPAS1/JAM3/ERBB3/PDSS2/MAFG/P4HB/PDGFA/CYBA/ITGB1/TOP2A/CENPW/METTL3/EXT2/RRAGA/TAF11	18
GO:0015485	cholesterol binding	3/996	50/18367	0.514231982383997	0.805611386120865	OSBPL10/PROM2/SCARB2	3
GO:0140359	ABC-type transporter activity	3/996	50/18367	0.514231982383997	0.805611386120865	ABCG2/ATP13A3/ABCB8	3
GO:0008195	phosphatidate phosphatase activity	1/996	13/18367	0.515693912771637	0.805611386120865	PLPP3	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/996	13/18367	0.515693912771637	0.805611386120865	SLC26A2	1
GO:0008417	fucosyltransferase activity	1/996	13/18367	0.515693912771637	0.805611386120865	FUT8	1
GO:0016840	carbon-nitrogen lyase activity	1/996	13/18367	0.515693912771637	0.805611386120865	ADSL	1
GO:0022851	GABA-gated chloride ion channel activity	1/996	13/18367	0.515693912771637	0.805611386120865	GABRE	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/996	13/18367	0.515693912771637	0.805611386120865	UBE4B	1
GO:0042301	phosphate ion binding	1/996	13/18367	0.515693912771637	0.805611386120865	GNG12	1
GO:0045504	dynein heavy chain binding	1/996	13/18367	0.515693912771637	0.805611386120865	DYNC1LI2	1
GO:0051011	microtubule minus-end binding	1/996	13/18367	0.515693912771637	0.805611386120865	CAMSAP2	1
GO:0061133	endopeptidase activator activity	1/996	13/18367	0.515693912771637	0.805611386120865	PSME3	1
GO:0070700	BMP receptor binding	1/996	13/18367	0.515693912771637	0.805611386120865	BMP7	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/996	13/18367	0.515693912771637	0.805611386120865	SYNJ1	1
GO:0003777	microtubule motor activity	4/996	69/18367	0.519078954330686	0.809556912217726	KIF26B/KIF16B/KIFC3/KIF4A	4
GO:0015399	primary active transmembrane transporter activity	10/996	181/18367	0.522140412225283	0.810670085359773	SLC26A2/ABCG2/ATP2B1/ATP13A3/CYC1/ATP6V1H/COX6A1/ATP6V1C2/ABCB8/SURF1	10
GO:0048306	calcium-dependent protein binding	5/996	88/18367	0.522905288576917	0.810670085359773	WFS1/CLN3/S100A4/ANXA2/ANXA3	5
GO:0008378	galactosyltransferase activity	2/996	32/18367	0.524095628433229	0.810670085359773	B3GNT5/B3GNT3	2
GO:0030515	snoRNA binding	2/996	32/18367	0.524095628433229	0.810670085359773	NUDT4/HEATR1	2
GO:0071889	14-3-3 protein binding	2/996	32/18367	0.524095628433229	0.810670085359773	IRS2/BAD	2
GO:0008200	ion channel inhibitor activity	2/996	33/18367	0.540821939219858	0.818950358550913	RASA1/WNK2	2
GO:0019956	chemokine binding	2/996	33/18367	0.540821939219858	0.818950358550913	ITGAV/ITGB1	2
GO:0016830	carbon-carbon lyase activity	3/996	52/18367	0.540951091126929	0.818950358550913	PISD/PDXDC1/AZIN1	3
GO:0017046	peptide hormone binding	3/996	52/18367	0.540951091126929	0.818950358550913	PRLR/IGF1R/SLC40A1	3
GO:0004298	threonine-type endopeptidase activity	1/996	14/18367	0.541975315347612	0.818950358550913	PSMB5	1
GO:0015373	anion:sodium symporter activity	1/996	14/18367	0.541975315347612	0.818950358550913	SLC6A4	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/996	14/18367	0.541975315347612	0.818950358550913	ECI1	1
GO:0044548	S100 protein binding	1/996	14/18367	0.541975315347612	0.818950358550913	ANXA2	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/996	14/18367	0.541975315347612	0.818950358550913	P2RY6	1
GO:0071837	HMG box domain binding	1/996	14/18367	0.541975315347612	0.818950358550913	DLX5	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/996	14/18367	0.541975315347612	0.818950358550913	SYNJ1	1
GO:0140666	annealing activity	1/996	14/18367	0.541975315347612	0.818950358550913	SMARCA1	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	12/996	222/18367	0.546820470395298	0.818950358550913	HGSNAT/GPAM/AGPAT1/TGM2/NCOA3/PNPLA2/ZDHHC3/BRCA2/MED24/ALAS1/HADHB/SPTLC3	12
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/996	53/18367	0.55398834929593	0.818950358550913	SLC6A4/SLC16A1/SLC5A3	3
GO:0016229	steroid dehydrogenase activity	2/996	34/18367	0.557135771373107	0.818950358550913	HSD17B1/HSD17B12	2
GO:0016248	channel inhibitor activity	2/996	34/18367	0.557135771373107	0.818950358550913	RASA1/WNK2	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/996	34/18367	0.557135771373107	0.818950358550913	CDKN1C/PKIB	2
GO:0045505	dynein intermediate chain binding	2/996	34/18367	0.557135771373107	0.818950358550913	HOOK3/DYNLL2	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/996	34/18367	0.557135771373107	0.818950358550913	SYNJ1/INPPL1	2
GO:0004175	endopeptidase activity	23/996	430/18367	0.558158249557512	0.818950358550913	ADAMTS1/ADAMTS19/CTSV/ADAMTS6/MME/MMP14/PRSS12/CTSL/PRSS8/MMP15/SPPL2B/LGMN/PSMB5/ADGRG6/AFG3L2/USP47/DPP4/GPAA1/USP14/ATG4C/BACE2/CAPN7/USP25	23
GO:0035064	methylated histone binding	4/996	73/18367	0.564056401065459	0.818950358550913	MORC4/SPIN1/CBX4/CBX5	4
GO:0140034	methylation-dependent protein binding	4/996	73/18367	0.564056401065459	0.818950358550913	MORC4/SPIN1/CBX4/CBX5	4
GO:0008374	O-acyltransferase activity	3/996	54/18367	0.566802260525847	0.818950358550913	GPAM/AGPAT1/PNPLA2	3
GO:0015459	potassium channel regulator activity	3/996	54/18367	0.566802260525847	0.818950358550913	RASA1/WNK2/SLC5A3	3
GO:0001846	opsonin binding	1/996	15/18367	0.56683188298853	0.818950358550913	ITGAV	1
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/996	15/18367	0.56683188298853	0.818950358550913	ALDH7A1	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/996	15/18367	0.56683188298853	0.818950358550913	PDE7A	1
GO:0004559	alpha-mannosidase activity	1/996	15/18367	0.56683188298853	0.818950358550913	MAN2B2	1
GO:0004953	icosanoid receptor activity	1/996	15/18367	0.56683188298853	0.818950358550913	PPARG	1
GO:0005161	platelet-derived growth factor receptor binding	1/996	15/18367	0.56683188298853	0.818950358550913	PDGFA	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/996	15/18367	0.56683188298853	0.818950358550913	GABRE	1
GO:0005545	1-phosphatidylinositol binding	1/996	15/18367	0.56683188298853	0.818950358550913	SCIN	1
GO:0008020	G protein-coupled photoreceptor activity	1/996	15/18367	0.56683188298853	0.818950358550913	OPN3	1
GO:0008559	ABC-type xenobiotic transporter activity	1/996	15/18367	0.56683188298853	0.818950358550913	ABCG2	1
GO:0015929	hexosaminidase activity	1/996	15/18367	0.56683188298853	0.818950358550913	NAGLU	1
GO:0016846	carbon-sulfur lyase activity	1/996	15/18367	0.56683188298853	0.818950358550913	MGST3	1
GO:0017136	NAD-dependent histone deacetylase activity	1/996	15/18367	0.56683188298853	0.818950358550913	HDAC6	1
GO:0047372	acylglycerol lipase activity	1/996	15/18367	0.56683188298853	0.818950358550913	ABHD12	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/996	15/18367	0.56683188298853	0.818950358550913	CYBA	1
GO:0050998	nitric-oxide synthase binding	1/996	15/18367	0.56683188298853	0.818950358550913	SLC6A4	1
GO:0051371	muscle alpha-actinin binding	1/996	15/18367	0.56683188298853	0.818950358550913	PDLIM1	1
GO:0098847	sequence-specific single stranded DNA binding	1/996	15/18367	0.56683188298853	0.818950358550913	RAD50	1
GO:1990825	sequence-specific mRNA binding	1/996	15/18367	0.56683188298853	0.818950358550913	DHX9	1
GO:0005254	chloride channel activity	4/996	74/18367	0.57493523417807	0.825075702241745	GABRE/CLDN4/FXYD3/CLIC4	4
GO:0017022	myosin binding	4/996	74/18367	0.57493523417807	0.825075702241745	CALD1/TRIOBP/VEZT/GSN	4
GO:0019905	syntaxin binding	4/996	74/18367	0.57493523417807	0.825075702241745	SLC6A4/SYT7/TMED9/NAPA	4
GO:0061630	ubiquitin protein ligase activity	16/996	304/18367	0.5857251753753	0.825075702241745	DTX4/RNF43/TRIML2/SIAH1/ZNRF3/UBR3/TRIM6/RNF128/MDM2/UBE4B/TRIM24/TRIM37/RNF114/MED24/TRIM27/HUWE1	16
GO:0042162	telomeric DNA binding	2/996	36/18367	0.588509741802312	0.825075702241745	UPF3A/RAD50	2
GO:0003774	cytoskeletal motor activity	6/996	114/18367	0.588788652090391	0.825075702241745	MYH10/KIF26B/KIF16B/MYO7A/KIFC3/KIF4A	6
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/996	16/18367	0.590340789077427	0.825075702241745	ALDH7A1	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/996	16/18367	0.590340789077427	0.825075702241745	CAPN7	1
GO:0004698	calcium-dependent protein kinase C activity	1/996	16/18367	0.590340789077427	0.825075702241745	PRKCI	1
GO:0005402	carbohydrate:cation symporter activity	1/996	16/18367	0.590340789077427	0.825075702241745	SLC5A3	1
GO:0005523	tropomyosin binding	1/996	16/18367	0.590340789077427	0.825075702241745	CALD1	1
GO:0008191	metalloendopeptidase inhibitor activity	1/996	16/18367	0.590340789077427	0.825075702241745	TIMP3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/996	16/18367	0.590340789077427	0.825075702241745	SLC22A11	1
GO:0016208	AMP binding	1/996	16/18367	0.590340789077427	0.825075702241745	ACSS1	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/996	16/18367	0.590340789077427	0.825075702241745	FEN1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/996	16/18367	0.590340789077427	0.825075702241745	HDAC6	1
GO:0042577	lipid phosphatase activity	1/996	16/18367	0.590340789077427	0.825075702241745	PLPP3	1
GO:0047498	calcium-dependent phospholipase A2 activity	1/996	16/18367	0.590340789077427	0.825075702241745	PLA2G12A	1
GO:0050700	CARD domain binding	1/996	16/18367	0.590340789077427	0.825075702241745	BCL10	1
GO:0070492	oligosaccharide binding	1/996	16/18367	0.590340789077427	0.825075702241745	CHID1	1
GO:1990380	Lys48-specific deubiquitinase activity	1/996	16/18367	0.590340789077427	0.825075702241745	USP27X	1
GO:1990404	protein ADP-ribosylase activity	1/996	16/18367	0.590340789077427	0.825075702241745	PARP2	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/996	56/18367	0.591739389261593	0.825805192125067	CST3/BIRC5/PRDX5	3
GO:0016409	palmitoyltransferase activity	2/996	37/18367	0.603565824813945	0.82671300749374	ZDHHC3/SPTLC3	2
GO:0042056	chemoattractant activity	2/996	37/18367	0.603565824813945	0.82671300749374	CCL5/PGF	2
GO:0004659	prenyltransferase activity	1/996	17/18367	0.612575031030393	0.82671300749374	PDSS2	1
GO:0004697	protein kinase C activity	1/996	17/18367	0.612575031030393	0.82671300749374	PRKCI	1
GO:0005005	transmembrane-ephrin receptor activity	1/996	17/18367	0.612575031030393	0.82671300749374	EPHB4	1
GO:0005149	interleukin-1 receptor binding	1/996	17/18367	0.612575031030393	0.82671300749374	TRIP6	1
GO:0008308	voltage-gated anion channel activity	1/996	17/18367	0.612575031030393	0.82671300749374	GPR89A	1
GO:0008392	arachidonic acid epoxygenase activity	1/996	17/18367	0.612575031030393	0.82671300749374	CYP2J2	1
GO:0008484	sulfuric ester hydrolase activity	1/996	17/18367	0.612575031030393	0.82671300749374	GNS	1
GO:0008574	plus-end-directed microtubule motor activity	1/996	17/18367	0.612575031030393	0.82671300749374	KIF16B	1
GO:0009881	photoreceptor activity	1/996	17/18367	0.612575031030393	0.82671300749374	OPN3	1
GO:0015095	magnesium ion transmembrane transporter activity	1/996	17/18367	0.612575031030393	0.82671300749374	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/996	17/18367	0.612575031030393	0.82671300749374	SLC26A2	1
GO:0015116	sulfate transmembrane transporter activity	1/996	17/18367	0.612575031030393	0.82671300749374	SLC26A2	1
GO:0015278	calcium-release channel activity	1/996	17/18367	0.612575031030393	0.82671300749374	MCOLN3	1
GO:0015377	cation:chloride symporter activity	1/996	17/18367	0.612575031030393	0.82671300749374	SLC6A4	1
GO:0017081	chloride channel regulator activity	1/996	17/18367	0.612575031030393	0.82671300749374	WNK2	1
GO:0030275	LRR domain binding	1/996	17/18367	0.612575031030393	0.82671300749374	PAWR	1
GO:0034185	apolipoprotein binding	1/996	17/18367	0.612575031030393	0.82671300749374	LRP1	1
GO:0043395	heparan sulfate proteoglycan binding	1/996	17/18367	0.612575031030393	0.82671300749374	LRP1	1
GO:0046965	retinoid X receptor binding	1/996	17/18367	0.612575031030393	0.82671300749374	PPARG	1
GO:0050780	dopamine receptor binding	1/996	17/18367	0.612575031030393	0.82671300749374	GNA12	1
GO:0052745	inositol phosphate phosphatase activity	1/996	17/18367	0.612575031030393	0.82671300749374	SYNJ1	1
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/996	38/18367	0.618200990962817	0.83073514049497	FKBP9/PPIC	2
GO:0004520	endodeoxyribonuclease activity	2/996	38/18367	0.618200990962817	0.83073514049497	FEN1/RAD50	2
GO:0140303	intramembrane lipid transporter activity	2/996	38/18367	0.618200990962817	0.83073514049497	TMEM30B/ATP10D	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3/996	59/18367	0.627359957084339	0.837103287515113	APEX2/ERI2/FEN1	3
GO:0032451	demethylase activity	2/996	39/18367	0.632416571643921	0.837103287515113	KDM5B/UTY	2
GO:0099106	ion channel regulator activity	7/996	139/18367	0.633595454801263	0.837103287515113	RASA1/WNK2/PRSS8/FXYD3/TSPAN13/PKP2/SLC5A3	7
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/996	18/18367	0.633603656049125	0.837103287515113	SYNJ1	1
GO:0008409	5'-3' exonuclease activity	1/996	18/18367	0.633603656049125	0.837103287515113	FEN1	1
GO:0008569	minus-end-directed microtubule motor activity	1/996	18/18367	0.633603656049125	0.837103287515113	KIFC3	1
GO:0016755	aminoacyltransferase activity	1/996	18/18367	0.633603656049125	0.837103287515113	TGM2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/996	18/18367	0.633603656049125	0.837103287515113	MARVELD3	1
GO:0050811	GABA receptor binding	1/996	18/18367	0.633603656049125	0.837103287515113	GABARAPL1	1
GO:0098918	structural constituent of synapse	1/996	18/18367	0.633603656049125	0.837103287515113	ACTN1	1
GO:0099095	ligand-gated anion channel activity	1/996	18/18367	0.633603656049125	0.837103287515113	GABRE	1
GO:1904047	S-adenosyl-L-methionine binding	1/996	18/18367	0.633603656049125	0.837103287515113	METTL3	1
GO:0001664	G protein-coupled receptor binding	15/996	295/18367	0.63892229086126	0.842947896346369	ITGB4/WLS/ADRB1/RNF43/DVL3/GNA12/LRP6/ZNRF3/GNAI1/ADM/GNA11/ARHGEF11/CCL5/REEP1/FEM1A	15
GO:0046873	metal ion transmembrane transporter activity	22/996	430/18367	0.642587930147923	0.846598363915165	SLC6A4/ITGAV/MCOLN3/TUSC3/KCNG1/SLC1A3/TRPV6/SLC39A9/ATP2B1/SLC39A11/SLC13A3/SLC39A10/KCNN4/SLC40A1/SLC11A2/TMEM37/SLC39A1/SLC38A2/SLC39A3/SLC39A7/SLC5A3/ANXA2	22
GO:0015144	carbohydrate transmembrane transporter activity	2/996	40/18367	0.646214990723047	0.849002121703083	SLC2A1/SLC5A3	2
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/996	40/18367	0.646214990723047	0.849002121703083	CYP2J2/COQ6	2
GO:0005507	copper ion binding	3/996	61/18367	0.649886790842735	0.850261657664973	F5/GPC1/SCO1	3
GO:0004745	NAD-retinol dehydrogenase activity	1/996	19/18367	0.653491974680934	0.850261657664973	RDH10	1
GO:0004890	GABA-A receptor activity	1/996	19/18367	0.653491974680934	0.850261657664973	GABRE	1
GO:0005003	ephrin receptor activity	1/996	19/18367	0.653491974680934	0.850261657664973	EPHB4	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/996	19/18367	0.653491974680934	0.850261657664973	PLEKHA5	1
GO:0016918	retinal binding	1/996	19/18367	0.653491974680934	0.850261657664973	OPN3	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/996	19/18367	0.653491974680934	0.850261657664973	SYNJ1	1
GO:0030331	estrogen receptor binding	2/996	41/18367	0.659599642366257	0.857024638771054	ISL1/DCAF13	2
GO:0005200	structural constituent of cytoskeleton	5/996	103/18367	0.663050786137983	0.860322094410441	DSP/EPB41L3/ANK3/CD2AP/VIM	5
GO:0140375	immune receptor activity	7/996	144/18367	0.670090370682848	0.860473180161879	LIFR/PRLR/CSF3R/CSF2RA/IL6ST/IL10RB/IL2RG	7
GO:0004620	phospholipase activity	5/996	104/18367	0.671378614802039	0.860473180161879	ABHD12/NOTUM/PLA2G12A/CCL5/LYPLA1	5
GO:0004551	nucleotide diphosphatase activity	1/996	20/18367	0.672301762844101	0.860473180161879	NUDT4	1
GO:0016018	cyclosporin A binding	1/996	20/18367	0.672301762844101	0.860473180161879	PPIC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/996	20/18367	0.672301762844101	0.860473180161879	GLDC	1
GO:0030506	ankyrin binding	1/996	20/18367	0.672301762844101	0.860473180161879	CDH1	1
GO:0031418	L-ascorbic acid binding	1/996	20/18367	0.672301762844101	0.860473180161879	PLOD2	1
GO:0031690	adrenergic receptor binding	1/996	20/18367	0.672301762844101	0.860473180161879	ADRB1	1
GO:0042288	MHC class I protein binding	1/996	20/18367	0.672301762844101	0.860473180161879	HLA-E	1
GO:0061608	nuclear import signal receptor activity	1/996	20/18367	0.672301762844101	0.860473180161879	TNPO1	1
GO:0001540	amyloid-beta binding	4/996	84/18367	0.674688292604862	0.862355999503093	LRP1/LDLR/CST3/ITM2C	4
GO:0016247	channel regulator activity	7/996	145/18367	0.677112733379804	0.863301658260817	RASA1/WNK2/PRSS8/FXYD3/TSPAN13/PKP2/SLC5A3	7
GO:0042393	histone binding	12/996	244/18367	0.677472409867654	0.863301658260817	KDM5B/MORC4/BRD4/CTSL/SPIN1/MCM2/NPM3/SMARCA2/TBL1X/CBX4/TRIM24/CBX5	12
GO:0019787	ubiquitin-like protein transferase activity	23/996	458/18367	0.679128182261816	0.863301658260817	DTX4/RNF43/LMO7/TRIML2/SIAH1/ZNRF3/UBR3/KLHL42/TRIM6/RNF128/CBX4/MDM2/UBE4B/TRIM24/ZNF451/TRIM37/RANBP2/TRIM28/RNF114/MED24/FBXO22/TRIM27/HUWE1	23
GO:1990782	protein tyrosine kinase binding	5/996	105/18367	0.679569590378505	0.863301658260817	PTPN14/TRIM6/TJP2/MAP3K7/ITGB1	5
GO:0016790	thiolester hydrolase activity	2/996	43/18367	0.685145407869572	0.863301658260817	ABHD12/LYPLA1	2
GO:0001614	purinergic nucleotide receptor activity	1/996	21/18367	0.690091452940971	0.863301658260817	P2RY6	1
GO:0001848	complement binding	1/996	21/18367	0.690091452940971	0.863301658260817	CD59	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/996	21/18367	0.690091452940971	0.863301658260817	AGPAT1	1
GO:0004407	histone deacetylase activity	1/996	21/18367	0.690091452940971	0.863301658260817	HDAC6	1
GO:0008373	sialyltransferase activity	1/996	21/18367	0.690091452940971	0.863301658260817	ST3GAL6	1
GO:0008391	arachidonic acid monooxygenase activity	1/996	21/18367	0.690091452940971	0.863301658260817	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/996	21/18367	0.690091452940971	0.863301658260817	ATP2B1	1
GO:0016502	nucleotide receptor activity	1/996	21/18367	0.690091452940971	0.863301658260817	P2RY6	1
GO:0051010	microtubule plus-end binding	1/996	21/18367	0.690091452940971	0.863301658260817	DST	1
GO:0140358	P-type transmembrane transporter activity	1/996	21/18367	0.690091452940971	0.863301658260817	ATP2B1	1
GO:0140416	transcription regulator inhibitor activity	1/996	21/18367	0.690091452940971	0.863301658260817	ID1	1
GO:0030145	manganese ion binding	3/996	65/18367	0.691974986993689	0.864509864387341	EXTL2/CDIPT/FEN1	3
GO:0043021	ribonucleoprotein complex binding	7/996	149/18367	0.704250271643592	0.870477344311228	MDM2/ABCE1/DHX9/RPN2/RICTOR/NME1/CBX5	7
GO:0016298	lipase activity	6/996	129/18367	0.706715420432097	0.870477344311228	ABHD12/NOTUM/PLA2G12A/CCL5/PNPLA2/LYPLA1	6
GO:0000062	fatty-acyl-CoA binding	1/996	22/18367	0.706916314647654	0.870477344311228	ACADVL	1
GO:0005540	hyaluronic acid binding	1/996	22/18367	0.706916314647654	0.870477344311228	HMMR	1
GO:0008320	protein transmembrane transporter activity	1/996	22/18367	0.706916314647654	0.870477344311228	SEC63	1
GO:0015106	bicarbonate transmembrane transporter activity	1/996	22/18367	0.706916314647654	0.870477344311228	SLC26A2	1
GO:0015296	anion:cation symporter activity	1/996	22/18367	0.706916314647654	0.870477344311228	SLC6A4	1
GO:0016917	GABA receptor activity	1/996	22/18367	0.706916314647654	0.870477344311228	GABRE	1
GO:0017075	syntaxin-1 binding	1/996	22/18367	0.706916314647654	0.870477344311228	SLC6A4	1
GO:0033558	protein deacetylase activity	1/996	22/18367	0.706916314647654	0.870477344311228	HDAC6	1
GO:0033691	sialic acid binding	1/996	22/18367	0.706916314647654	0.870477344311228	SIGLEC6	1
GO:0016746	acyltransferase activity	12/996	250/18367	0.709036545421268	0.87183683179649	HGSNAT/GPAM/AGPAT1/TGM2/NCOA3/PNPLA2/ZDHHC3/BRCA2/MED24/ALAS1/HADHB/SPTLC3	12
GO:0005126	cytokine receptor binding	13/996	271/18367	0.714795978339321	0.87183683179649	LIFR/PRLR/RASL11B/TGFBR3/IL6ST/EFNA5/TRAF4/TRIP6/FERMT2/CCL5/TRIM37/CD2AP/PGF	13
GO:0008081	phosphoric diester hydrolase activity	4/996	89/18367	0.718034499064583	0.87183683179649	APEX2/NOTUM/CCL5/PDE7A	4
GO:0043178	alcohol binding	4/996	89/18367	0.718034499064583	0.87183683179649	OSBPL10/PROM2/CDIPT/SCARB2	4
GO:0000149	SNARE binding	5/996	110/18367	0.71844817332041	0.87183683179649	SLC6A4/SYT7/ANKRD27/TMED9/NAPA	5
GO:0016782	transferase activity, transferring sulphur-containing groups	3/996	68/18367	0.720958322880181	0.87183683179649	DSEL/TST/MOCS2	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/996	23/18367	0.722828625937429	0.87183683179649	PARP2	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/996	23/18367	0.722828625937429	0.87183683179649	PDE7A	1
GO:0005212	structural constituent of eye lens	1/996	23/18367	0.722828625937429	0.87183683179649	VIM	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/996	23/18367	0.722828625937429	0.87183683179649	PRKCI	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/996	23/18367	0.722828625937429	0.87183683179649	CDO1	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/996	23/18367	0.722828625937429	0.87183683179649	AGPAT1	1
GO:0070412	R-SMAD binding	1/996	23/18367	0.722828625937429	0.87183683179649	PPARG	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/996	23/18367	0.722828625937429	0.87183683179649	TAB3	1
GO:0071617	lysophospholipid acyltransferase activity	1/996	23/18367	0.722828625937429	0.87183683179649	AGPAT1	1
GO:1901567	fatty acid derivative binding	1/996	23/18367	0.722828625937429	0.87183683179649	ACADVL	1
GO:0035254	glutamate receptor binding	2/996	47/18367	0.73150437591966	0.878736941141311	SHANK2/FLOT2	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/996	47/18367	0.73150437591966	0.878736941141311	ADRB1/GABRE	2
GO:0016407	acetyltransferase activity	4/996	91/18367	0.734132700067891	0.878736941141311	HGSNAT/NCOA3/BRCA2/MED24	4
GO:0005319	lipid transporter activity	7/996	154/18367	0.735989734384352	0.878736941141311	SLC27A2/OSBPL10/PLEKHA8/SLC2A1/TMEM30B/TRIAP1/ATP10D	7
GO:0000030	mannosyltransferase activity	1/996	24/18367	0.737877834864943	0.878736941141311	TMTC3	1
GO:0015295	solute:proton symporter activity	1/996	24/18367	0.737877834864943	0.878736941141311	SLC11A2	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/996	24/18367	0.737877834864943	0.878736941141311	CDO1	1
GO:0043274	phospholipase binding	1/996	24/18367	0.737877834864943	0.878736941141311	PDPK1	1
GO:0070003	threonine-type peptidase activity	1/996	24/18367	0.737877834864943	0.878736941141311	PSMB5	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/996	24/18367	0.737877834864943	0.878736941141311	BMP7	1
GO:0070888	E-box binding	2/996	48/18367	0.74214784928678	0.881576055054619	BHLHE41/PPARG	2
GO:0120013	lipid transfer activity	2/996	48/18367	0.74214784928678	0.881576055054619	PLEKHA8/TRIAP1	2
GO:0015085	calcium ion transmembrane transporter activity	6/996	135/18367	0.746849878174527	0.881576055054619	ITGAV/MCOLN3/TRPV6/ATP2B1/TMEM37/ANXA2	6
GO:0003887	DNA-directed DNA polymerase activity	1/996	25/18367	0.752110712609834	0.881576055054619	POLQ	1
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/996	25/18367	0.752110712609834	0.881576055054619	PDE7A	1
GO:0005112	Notch binding	1/996	25/18367	0.752110712609834	0.881576055054619	GALNT11	1
GO:0005227	calcium activated cation channel activity	1/996	25/18367	0.752110712609834	0.881576055054619	KCNN4	1
GO:0008327	methyl-CpG binding	1/996	25/18367	0.752110712609834	0.881576055054619	DNMT1	1
GO:0035035	histone acetyltransferase binding	1/996	25/18367	0.752110712609834	0.881576055054619	GLI3	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	1/996	25/18367	0.752110712609834	0.881576055054619	RBMS3	1
GO:0120227	acyl-CoA binding	1/996	25/18367	0.752110712609834	0.881576055054619	ACADVL	1
GO:0032813	tumor necrosis factor receptor superfamily binding	2/996	49/18367	0.752427970556171	0.881576055054619	TRAF4/TRIM37	2
GO:0043539	protein serine/threonine kinase activator activity	2/996	49/18367	0.752427970556171	0.881576055054619	ALS2/RICTOR	2
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	3/996	72/18367	0.756240264925458	0.884869142764383	CYC1/COX6A1/SURF1	3
GO:0005048	signal sequence binding	2/996	50/18367	0.762352803396679	0.884869142764383	TNPO1/NUP153	2
GO:0004435	phosphatidylinositol phospholipase C activity	1/996	26/18367	0.765571498251563	0.884869142764383	CCL5	1
GO:0004806	triglyceride lipase activity	1/996	26/18367	0.765571498251563	0.884869142764383	PNPLA2	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/996	26/18367	0.765571498251563	0.884869142764383	ZDHHC3	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/996	26/18367	0.765571498251563	0.884869142764383	ZDHHC3	1
GO:0038187	pattern recognition receptor activity	1/996	26/18367	0.765571498251563	0.884869142764383	COLEC12	1
GO:0042974	retinoic acid receptor binding	1/996	26/18367	0.765571498251563	0.884869142764383	PPARG	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/996	26/18367	0.765571498251563	0.884869142764383	SLC26A2	1
GO:0097602	cullin family protein binding	1/996	26/18367	0.765571498251563	0.884869142764383	DDB1	1
GO:0099604	ligand-gated calcium channel activity	1/996	26/18367	0.765571498251563	0.884869142764383	MCOLN3	1
GO:0019210	kinase inhibitor activity	3/996	74/18367	0.77248551125018	0.891766362252046	LRP6/CDKN1C/PKIB	3
GO:0004683	calmodulin-dependent protein kinase activity	1/996	27/18367	0.778302035721791	0.894098192256008	CAMK2G	1
GO:0022884	macromolecule transmembrane transporter activity	1/996	27/18367	0.778302035721791	0.894098192256008	SEC63	1
GO:0023026	MHC class II protein complex binding	1/996	27/18367	0.778302035721791	0.894098192256008	B2M	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/996	27/18367	0.778302035721791	0.894098192256008	SYNJ1	1
GO:0005262	calcium channel activity	5/996	119/18367	0.779693264471974	0.894605426470889	ITGAV/MCOLN3/TRPV6/TMEM37/ANXA2	5
GO:0008083	growth factor activity	7/996	162/18367	0.781678780980369	0.895792471634438	BMP7/EFEMP1/PTN/PDGFA/NENF/GRN/PGF	7
GO:0050661	NADP binding	2/996	53/18367	0.790078862640692	0.904318698186552	HSD17B1/IDH1	2
GO:0004842	ubiquitin-protein transferase activity	20/996	433/18367	0.80153611759698	0.911011195818608	DTX4/RNF43/LMO7/TRIML2/SIAH1/ZNRF3/UBR3/KLHL42/TRIM6/RNF128/MDM2/UBE4B/TRIM24/TRIM37/TRIM28/RNF114/MED24/FBXO22/TRIM27/HUWE1	20
GO:0004181	metallocarboxypeptidase activity	1/996	29/18367	0.801728536447586	0.911011195818608	NAALAD2	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/996	29/18367	0.801728536447586	0.911011195818608	CDK6	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/996	29/18367	0.801728536447586	0.911011195818608	KIF16B	1
GO:0051787	misfolded protein binding	1/996	29/18367	0.801728536447586	0.911011195818608	HDAC6	1
GO:0097472	cyclin-dependent protein kinase activity	1/996	29/18367	0.801728536447586	0.911011195818608	CDK6	1
GO:0004497	monooxygenase activity	4/996	102/18367	0.810422446893071	0.919780656594304	MICAL3/SQLE/CYP2J2/COQ6	4
GO:0005217	intracellular ligand-gated ion channel activity	1/996	30/18367	0.812497343171231	0.919918866907812	MCOLN3	1
GO:0016417	S-acyltransferase activity	1/996	30/18367	0.812497343171231	0.919918866907812	ZDHHC3	1
GO:0052689	carboxylic ester hydrolase activity	6/996	147/18367	0.814856562529637	0.921482451264008	PGAP1/ABHD12/NOTUM/PLA2G12A/PNPLA2/LYPLA1	6
GO:0140142	nucleocytoplasmic carrier activity	1/996	31/18367	0.82268181425164	0.929216149910125	TNPO1	1
GO:0001222	transcription corepressor binding	1/996	32/18367	0.832313626697395	0.935607919270819	HDAC6	1
GO:0030332	cyclin binding	1/996	32/18367	0.832313626697395	0.935607919270819	CDK6	1
GO:0031624	ubiquitin conjugating enzyme binding	1/996	32/18367	0.832313626697395	0.935607919270819	SIAH1	1
GO:0048019	receptor antagonist activity	1/996	32/18367	0.832313626697395	0.935607919270819	CCL5	1
GO:0004519	endonuclease activity	5/996	129/18367	0.83510802907457	0.937630230498505	APEX2/REXO4/FEN1/N4BP2/RAD50	5
GO:0004623	phospholipase A2 activity	1/996	33/18367	0.841422741931068	0.942473511176059	PLA2G12A	1
GO:0005251	delayed rectifier potassium channel activity	1/996	33/18367	0.841422741931068	0.942473511176059	KCNG1	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/996	34/18367	0.850037498614643	0.950992070896666	FEN1	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	6/996	156/18367	0.855747375617199	0.956244398376514	COMT/COQ5/METTL3/DNMT1/KMT5A/LCMT1	6
GO:0098960	postsynaptic neurotransmitter receptor activity	2/996	62/18367	0.856824092862785	0.95631314629946	ADRB1/GABRE	2
GO:0000175	3'-5'-exoribonuclease activity	1/996	35/18367	0.858184700457211	0.956698210450524	ERI2	1
GO:0015248	sterol transporter activity	1/996	36/18367	0.865889699275923	0.960739807677172	OSBPL10	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/996	36/18367	0.865889699275923	0.960739807677172	ATIC	1
GO:0023023	MHC protein complex binding	1/996	36/18367	0.865889699275923	0.960739807677172	B2M	1
GO:0034061	DNA polymerase activity	1/996	36/18367	0.865889699275923	0.960739807677172	POLQ	1
GO:0030551	cyclic nucleotide binding	1/996	37/18367	0.873176473566533	0.967684985999617	SLC19A1	1
GO:0043022	ribosome binding	2/996	66/18367	0.879745564967233	0.968485719698808	RPN2/RICTOR	2
GO:0008395	steroid hydroxylase activity	1/996	38/18367	0.880067702826093	0.968485719698808	CYP2J2	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/996	38/18367	0.880067702826093	0.968485719698808	TAF11	1
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	1/996	38/18367	0.880067702826093	0.968485719698808	ERI2	1
GO:0019213	deacetylase activity	1/996	38/18367	0.880067702826093	0.968485719698808	HDAC6	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/996	38/18367	0.880067702826093	0.968485719698808	SIAH1	1
GO:0045182	translation regulator activity	5/996	140/18367	0.88233027512096	0.9698426127934	IGF2BP3/EIF2AK4/CYFIP1/EIF1AY/RPL10	5
GO:0004518	nuclease activity	8/996	210/18367	0.888251991468944	0.97521372489947	APEX2/REXO4/ERI2/FEN1/N4BP2/NME1/RAD50/DDX1	8
GO:0004532	exoribonuclease activity	1/996	40/18367	0.892748167270899	0.976734928651785	ERI2	1
GO:0042287	MHC protein binding	1/996	40/18367	0.892748167270899	0.976734928651785	HLA-E	1
GO:0044183	protein folding chaperone	1/996	40/18367	0.892748167270899	0.976734928651785	DFFA	1
GO:0008236	serine-type peptidase activity	7/996	191/18367	0.898558350336994	0.981551491794597	CTSV/NAALAD2/MMP14/PRSS12/PRSS8/DPP4/CPVL	7
GO:0004860	protein kinase inhibitor activity	2/996	70/18367	0.899234540784222	0.981551491794597	CDKN1C/PKIB	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/996	71/18367	0.903624729601795	0.984063000329353	TGM2/HDAC6	2
GO:0031491	nucleosome binding	2/996	71/18367	0.903624729601795	0.984063000329353	PARP2/SMARCA1	2
GO:0003823	antigen binding	6/996	171/18367	0.907230937135035	0.984786978354518	TSPAN4/HLA-B/HLA-A/HLA-C/DHCR24/HLA-E	6
GO:0005246	calcium channel regulator activity	1/996	43/18367	0.909302072459927	0.984786978354518	TSPAN13	1
GO:0018024	histone-lysine N-methyltransferase activity	1/996	43/18367	0.909302072459927	0.984786978354518	KMT5A	1
GO:0030547	signaling receptor inhibitor activity	1/996	43/18367	0.909302072459927	0.984786978354518	CCL5	1
GO:0017171	serine hydrolase activity	7/996	195/18367	0.909516636059905	0.984786978354518	CTSV/NAALAD2/MMP14/PRSS12/PRSS8/DPP4/CPVL	7
GO:0140104	molecular carrier activity	2/996	73/18367	0.911873995942694	0.985362128116085	TNPO1/SCO1	2
GO:0022839	ion gated channel activity	1/996	44/18367	0.914231953262694	0.985362128116085	KCNN4	1
GO:0051879	Hsp90 protein binding	1/996	44/18367	0.914231953262694	0.985362128116085	HDAC6	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/996	44/18367	0.914231953262694	0.985362128116085	GABRE	1
GO:0005506	iron ion binding	5/996	151/18367	0.917484773686947	0.985875018044346	PLOD2/CYP2J2/TET2/ABCE1/CDO1	5
GO:0005245	voltage-gated calcium channel activity	1/996	45/18367	0.918894125098658	0.985875018044346	ITGAV	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/996	45/18367	0.918894125098658	0.985875018044346	FEN1	1
GO:0140223	general transcription initiation factor activity	1/996	45/18367	0.918894125098658	0.985875018044346	TAF11	1
GO:0015081	sodium ion transmembrane transporter activity	5/996	152/18367	0.920168460871647	0.986119101411936	SLC6A4/SLC1A3/SLC13A3/SLC38A2/SLC5A3	5
GO:0004864	protein phosphatase inhibitor activity	1/996	46/18367	0.923303111639523	0.988354012686853	PTN	1
GO:0016741	transferase activity, transferring one-carbon groups	8/996	225/18367	0.92586420348803	0.989970578530902	COMT/COQ5/METTL3/GCSH/DNMT1/KMT5A/LCMT1/ATIC	8
GO:0030971	receptor tyrosine kinase binding	2/996	78/18367	0.929690005423982	0.992934223480035	PTPN14/MAP3K7	2
GO:0048020	CCR chemokine receptor binding	1/996	48/18367	0.931415730225453	0.993650756367357	CCL5	1
GO:0019208	phosphatase regulator activity	3/996	107/18367	0.934407902052099	0.994250849498743	PTN/PPP4R1/PPP1R12B	3
GO:0008009	chemokine activity	1/996	49/18367	0.935144641885229	0.994250849498743	CCL5	1
GO:0019212	phosphatase inhibitor activity	1/996	49/18367	0.935144641885229	0.994250849498743	PTN	1
GO:0003743	translation initiation factor activity	1/996	51/18367	0.942005813933381	0.998165890579578	EIF1AY	1
GO:0008227	G protein-coupled amine receptor activity	1/996	51/18367	0.942005813933381	0.998165890579578	ADRB1	1
GO:0051018	protein kinase A binding	1/996	51/18367	0.942005813933381	0.998165890579578	DACT2	1
GO:0008146	sulfotransferase activity	1/996	52/18367	0.94515946152687	0.999324499175079	DSEL	1
GO:0008168	methyltransferase activity	7/996	214/18367	0.948725127997011	0.999324499175079	COMT/COQ5/METTL3/GCSH/DNMT1/KMT5A/LCMT1	7
GO:0008276	protein methyltransferase activity	2/996	88/18367	0.955610817161808	0.999324499175079	KMT5A/LCMT1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/996	88/18367	0.955610817161808	0.999324499175079	CYB5R1/CYBA	2
GO:0042054	histone methyltransferase activity	1/996	56/18367	0.956151263457743	0.999324499175079	KMT5A	1
GO:0051287	NAD binding	1/996	56/18367	0.956151263457743	0.999324499175079	IDH1	1
GO:0019888	protein phosphatase regulator activity	2/996	89/18367	0.957629099213286	0.999324499175079	PTN/PPP4R1	2
GO:0030546	signaling receptor activator activity	19/996	495/18367	0.959119389592104	0.999324499175079	FBN1/SEMA6D/SEMA6A/APP/BMP7/EFEMP1/SEMA3F/SEMA4C/PTN/EFNA5/ADM/FAM3B/CCL5/PDGFA/NENF/GRN/DPP4/PGF/IL32	19
GO:0004252	serine-type endopeptidase activity	5/996	174/18367	0.962576652035403	0.999324499175079	CTSV/MMP14/PRSS12/PRSS8/DPP4	5
GO:0016279	protein-lysine N-methyltransferase activity	1/996	59/18367	0.962924732718981	0.999324499175079	KMT5A	1
GO:0036002	pre-mRNA binding	1/996	59/18367	0.962924732718981	0.999324499175079	TARDBP	1
GO:0016278	lysine N-methyltransferase activity	1/996	60/18367	0.964941717982904	0.999324499175079	KMT5A	1
GO:0022824	transmitter-gated ion channel activity	1/996	60/18367	0.964941717982904	0.999324499175079	GABRE	1
GO:0022835	transmitter-gated channel activity	1/996	60/18367	0.964941717982904	0.999324499175079	GABRE	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/996	125/18367	0.968759220579672	0.999324499175079	TGM2/HDAC6/ATIC	3
GO:0008173	RNA methyltransferase activity	1/996	65/18367	0.973496584018091	0.999324499175079	METTL3	1
GO:0031072	heat shock protein binding	3/996	129/18367	0.973627913990493	0.999324499175079	HDAC6/TFAM/BAG1	3
GO:0031490	chromatin DNA binding	2/996	103/18367	0.978108965700472	0.999324499175079	UTY/DHX9	2
GO:0005216	ion channel activity	15/996	432/18367	0.978361571107121	0.999324499175079	ITGAV/MCOLN3/TMEM150C/TMC5/GABRE/CLDN4/GPR89A/KCNG1/TRPV6/FXYD3/KCNN4/TMEM37/CLIC4/ANXA2/LRRC8D	15
GO:0004521	endoribonuclease activity	1/996	69/18367	0.978812181141202	0.999324499175079	FEN1	1
GO:0015267	channel activity	17/996	480/18367	0.979580316628608	0.999324499175079	GJA1/ITGAV/MCOLN3/TMEM150C/TMC5/GJA5/GABRE/CLDN4/GPR89A/KCNG1/TRPV6/FXYD3/KCNN4/TMEM37/CLIC4/ANXA2/LRRC8D	17
GO:0022803	passive transmembrane transporter activity	17/996	481/18367	0.980082193415615	0.999324499175079	GJA1/ITGAV/MCOLN3/TMEM150C/TMC5/GJA5/GABRE/CLDN4/GPR89A/KCNG1/TRPV6/FXYD3/KCNN4/TMEM37/CLIC4/ANXA2/LRRC8D	17
GO:0000049	tRNA binding	1/996	72/18367	0.982087334938078	0.999324499175079	EIF2AK4	1
GO:0042379	chemokine receptor binding	1/996	72/18367	0.982087334938078	0.999324499175079	CCL5	1
GO:0020037	heme binding	3/996	139/18367	0.982842869659803	0.999324499175079	CYC1/CYP2J2/CYBA	3
GO:0048018	receptor ligand activity	17/996	487/18367	0.982866678841444	0.999324499175079	FBN1/SEMA6D/SEMA6A/BMP7/EFEMP1/SEMA3F/SEMA4C/PTN/ADM/FAM3B/CCL5/PDGFA/NENF/GRN/DPP4/PGF/IL32	17
GO:0005230	extracellular ligand-gated ion channel activity	1/996	73/18367	0.983062520201903	0.999324499175079	GABRE	1
GO:0030594	neurotransmitter receptor activity	2/996	111/18367	0.985088427187092	0.999324499175079	ADRB1/GABRE	2
GO:0003730	mRNA 3'-UTR binding	5/996	201/18367	0.986200630267207	0.999324499175079	IGF2BP3/RBMS3/PUM1/TARDBP/PUM2	5
GO:0005244	voltage-gated ion channel activity	5/996	201/18367	0.986200630267207	0.999324499175079	ITGAV/GPR89A/KCNG1/TMEM37/CLIC4	5
GO:0022832	voltage-gated channel activity	5/996	201/18367	0.986200630267207	0.999324499175079	ITGAV/GPR89A/KCNG1/TMEM37/CLIC4	5
GO:0004540	ribonuclease activity	2/996	116/18367	0.98829437364047	0.999324499175079	ERI2/FEN1	2
GO:0046906	tetrapyrrole binding	3/996	149/18367	0.988929454921613	0.999324499175079	CYC1/CYP2J2/CYBA	3
GO:0140098	catalytic activity, acting on RNA	12/996	386/18367	0.989078989796516	0.999324499175079	GATB/TRIT1/ERI2/FEN1/RTCB/AQR/DHX32/DDX3Y/DHX9/METTL3/DHX15/DDX1	12
GO:0022836	gated channel activity	10/996	340/18367	0.990067376298386	0.999324499175079	ITGAV/MCOLN3/TMEM150C/TMC5/GABRE/GPR89A/KCNG1/KCNN4/TMEM37/CLIC4	10
GO:0005267	potassium channel activity	2/996	121/18367	0.990824672838491	0.999324499175079	KCNG1/KCNN4	2
GO:0008135	translation factor activity, RNA binding	1/996	84/18367	0.99085185627835	0.999324499175079	EIF1AY	1
GO:0005179	hormone activity	2/996	122/18367	0.991262372767617	0.999324499175079	FBN1/ADM	2
GO:0140101	catalytic activity, acting on a tRNA	2/996	124/18367	0.992077420115635	0.999324499175079	GATB/TRIT1	2
GO:0005249	voltage-gated potassium channel activity	1/996	90/18367	0.993463496739762	0.999324499175079	KCNG1	1
GO:0016779	nucleotidyltransferase activity	2/996	132/18367	0.994656085686804	0.999324499175079	POLQ/CDS1	2
GO:0008170	N-methyltransferase activity	1/996	97/18367	0.995584657235733	0.999324499175079	KMT5A	1
GO:0005125	cytokine activity	5/996	235/18367	0.996388333391903	0.999324499175079	BMP7/FAM3B/CCL5/GRN/IL32	5
GO:0015276	ligand-gated ion channel activity	2/996	143/18367	0.996905630032461	0.999324499175079	MCOLN3/GABRE	2
GO:0022834	ligand-gated channel activity	2/996	143/18367	0.996905630032461	0.999324499175079	MCOLN3/GABRE	2
GO:0022843	voltage-gated cation channel activity	2/996	143/18367	0.996905630032461	0.999324499175079	ITGAV/KCNG1	2
GO:0008528	G protein-coupled peptide receptor activity	2/996	147/18367	0.997466487915853	0.999324499175079	LGR4/LGR5	2
GO:0003735	structural constituent of ribosome	3/996	182/18367	0.997514957119562	0.999324499175079	RPS4Y1/MRPL15/RPL10	3
GO:0090079	translation regulator activity, nucleic acid binding	1/996	108/18367	0.997617202928666	0.999324499175079	EIF1AY	1
GO:0001653	peptide receptor activity	2/996	153/18367	0.998125308830618	0.999324499175079	LGR4/LGR5	2
GO:0099094	ligand-gated cation channel activity	1/996	113/18367	0.998200011452701	0.999324499175079	MCOLN3	1
GO:0015079	potassium ion transmembrane transporter activity	2/996	155/18367	0.998304883849144	0.999324499175079	KCNG1/KCNN4	2
GO:0005261	cation channel activity	7/996	335/18367	0.999324499175079	0.999324499175079	ITGAV/MCOLN3/KCNG1/TRPV6/KCNN4/TMEM37/ANXA2	7