ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0007163 establishment or maintenance of cell polarity 35/982 218/18722 3.1671847852796e-09 1.65200358400184e-05 GJA1/KANK1/DST/AMOTL1/KIF26B/FERMT1/FRMD4A/WWC1/AMOTL2/WEE1/AMOT/DLG5/FAT1/SPINT2/JAM3/PRKCI/RHOBTB3/PDLIM1/ARHGEF11/MAP7/PARD3/PTK2/MPP7/RHOBTB1/SPDL1/LMNA/CYTH3/ITGB1/GSN/RICTOR/FLOT2/FRMD4B/CLIC4/SDCCAG8/RND3 35 GO:0072001 renal system development 42/982 302/18722 7.47017209122026e-09 1.94822088139024e-05 LRP2/FBN1/ADAMTS1/ENPEP/LGR4/PBX1/FRAS1/IRX2/KIF26B/FGFR2/TACSTD2/ADAMTS6/BMP7/LGR5/FREM2/LAMA5/SOX4/YAP1/MME/NRP1/MAGED1/NF1/DLG5/RDH10/CENPF/WFS1/SERPINF1/TFAP2A/DACT2/GLI3/CD24/BASP1/PDGFA/NPHP3/COL4A1/AHI1/PPAT/MTSS1/AKR1B1/SMAD5/FOXC1/ASS1 42 GO:0001822 kidney development 40/982 293/18722 2.87047591933953e-08 4.55458750749011e-05 LRP2/FBN1/ADAMTS1/ENPEP/LGR4/PBX1/FRAS1/IRX2/KIF26B/FGFR2/TACSTD2/ADAMTS6/BMP7/FREM2/LAMA5/SOX4/YAP1/MME/NRP1/MAGED1/NF1/DLG5/RDH10/CENPF/WFS1/SERPINF1/TFAP2A/DACT2/GLI3/CD24/BASP1/PDGFA/NPHP3/AHI1/PPAT/MTSS1/AKR1B1/SMAD5/FOXC1/ASS1 40 GO:0061458 reproductive system development 51/982 427/18722 3.49278183089732e-08 4.55458750749011e-05 LRP2/ADAMTS1/GJA1/LGR4/NR2F2/CTSV/FGFR2/BMP7/KDM5B/SPINT1/MME/DLX3/MMP14/PPARG/ITGB8/EPAS1/CHD7/PTN/ADGRG1/SPINT2/ASPM/RDH10/ADM/TFAP2C/SERPINF1/RHOBTB3/GLI3/TFEB/SPATA2/PLEKHA5/PHLDA2/DHCR24/PTK2/CCND1/RAB13/BASP1/CEBPA/PPARD/TBX3/IDH1/NUPR1/PRDX4/PSAP/BRCA2/WDR48/TRIM28/BSG/FOXC1/KRT8/RBPJ/RRM1 51 GO:0035329 hippo signaling 13/982 40/18722 6.73255693879179e-08 4.9087449827743e-05 TEAD1/AMOTL1/SHANK2/YAP1/WWC1/AMOTL2/TEAD3/AMOT/DLG5/LATS2/WWC3/NEK8/VGLL4 13 GO:0001655 urogenital system development 43/982 338/18722 6.98951636588822e-08 4.9087449827743e-05 LRP2/FBN1/ADAMTS1/ENPEP/LGR4/PBX1/FRAS1/IRX2/KIF26B/FGFR2/TACSTD2/ADAMTS6/BMP7/LGR5/FREM2/LAMA5/SOX4/YAP1/MME/NRP1/MAGED1/NF1/DLG5/RDH10/CENPF/WFS1/SERPINF1/TFAP2A/DACT2/GLI3/CD24/BASP1/PDGFA/NPHP3/COL4A1/PSAP/AHI1/PPAT/MTSS1/AKR1B1/SMAD5/FOXC1/ASS1 43 GO:0048608 reproductive structure development 50/982 424/18722 7.14551505030779e-08 4.9087449827743e-05 LRP2/ADAMTS1/GJA1/LGR4/NR2F2/CTSV/FGFR2/BMP7/KDM5B/SPINT1/MME/DLX3/MMP14/PPARG/ITGB8/EPAS1/CHD7/PTN/ADGRG1/SPINT2/ASPM/RDH10/ADM/TFAP2C/SERPINF1/RHOBTB3/GLI3/TFEB/SPATA2/PHLDA2/DHCR24/PTK2/CCND1/RAB13/BASP1/CEBPA/PPARD/TBX3/IDH1/NUPR1/PRDX4/PSAP/BRCA2/WDR48/TRIM28/BSG/FOXC1/KRT8/RBPJ/RRM1 50 GO:0031589 cell-substrate adhesion 45/982 363/18722 7.52874997358021e-08 4.9087449827743e-05 LAMB1/ITGB4/LAMC1/CCDC80/DAG1/KANK1/ITGAV/LRP1/BCAM/SGCE/PIP5K1A/TACSTD2/LAMA5/ITGB5/ITGA6/FERMT1/SORBS1/NRP1/RASA1/PTPRK/MMP14/GCNT2/FBLN1/FER/PTN/NF1/EFNA5/JAM3/DOCK1/ID1/CTTN/TRIOBP/EFNA1/PTK2/ACTN1/TRIP6/FERMT2/P4HB/PPARD/CDK6/MAP4K4/PPFIA1/ITGB1/HSD17B12/PDPK1 45 GO:0030010 establishment of cell polarity 25/982 143/18722 1.02662588546292e-07 5.94986735397174e-05 GJA1/KANK1/AMOTL1/KIF26B/FERMT1/FRMD4A/WWC1/AMOTL2/WEE1/AMOT/FAT1/JAM3/PRKCI/ARHGEF11/PARD3/PTK2/MPP7/SPDL1/CYTH3/ITGB1/GSN/RICTOR/FLOT2/FRMD4B/SDCCAG8 25 GO:0060562 epithelial tube morphogenesis 41/982 325/18722 1.77083222269499e-07 8.43747297970304e-05 LRP2/DAG1/LGR4/PBX1/MET/IRX2/LRP5/KIF26B/FGFR2/COBL/TACSTD2/BMP7/LGR5/KDM5B/LAMA5/SPINT1/SOX4/YAP1/DVL3/NRP1/MMP14/SEMA4C/MAGED1/FOLR1/DLG5/SPINT2/RDH10/ADM/PLXNB2/GLI3/ESRP2/LMO4/FZD6/TBX3/NPHP3/COL4A1/AHI1/MTSS1/CLIC4/BCL10/RBPJ 41 GO:0001667 ameboidal-type cell migration 53/982 475/18722 1.77937505323492e-07 8.43747297970304e-05 ITGB4/GJA1/PLPP3/SEMA6D/KANK1/NR2F2/SEMA6A/MET/AMOTL1/LRP5/NRP2/PIP5K1A/TACSTD2/BMP7/TPBG/LAMA5/ISL1/FERMT1/NRP1/GNA12/AMOTL2/SEMA3F/PPARG/SEMA4C/FER/FOLR1/PTN/NF1/AMOT/DOCK1/ID1/TMSB4X/MARVELD3/SERPINF1/EFNA1/EPHB4/PDLIM1/PTK2/RAB13/CLN3/HDAC6/SPARC/PPARD/LGMN/MAP4K4/ITGB1/GRN/PLK2/FSTL1/DPP4/CAPN7/PDPK1/ANXA3 53 GO:0007015 actin filament organization 50/982 441/18722 2.43585811488069e-07 0.000105878632726814 KANK1/MET/COBL/TACSTD2/KANK4/SCIN/ITGB5/PAWR/SORBS1/NRP1/RASA1/SWAP70/SYNPO/FER/FAT1/MYO7A/CYFIP1/MICAL3/PPP1R9A/ID1/CTTN/CALD1/TMSB4X/ELMO3/TRIOBP/PRKCI/RHOBTB3/TJP1/PDLIM1/NCKAP1/WASL/ACTN1/RHOBTB1/FERMT2/EPS8/MSRB2/DIAPH3/PPFIA1/LIMA1/BIN3/MTSS1/ENAH/INPPL1/GSN/HSP90B1/RICTOR/CD2AP/TRIM27/F11R/RND3 50 GO:0050678 regulation of epithelial cell proliferation 45/982 381/18722 3.07703061605951e-07 0.000123459936102819 LAMB1/LAMC1/GJA1/NR2F2/EGFR/NRP2/FGFR2/KDM5B/ISL1/YAP1/NRP1/PTPRK/NFIB/DLX6/TGFBR3/PPARG/MAGED1/PTN/NF1/B2M/ID1/MARVELD3/FLT1/CDKN1C/SERPINF1/DLX5/HRAS/ESRP2/CCND1/SPARC/PPARD/IFT74/CYBA/CDK6/NUPR1/GRN/BRCA2/WDR48/MTSS1/RICTOR/TCF7L2/PGF/BAD/NME1/PDPK1 45 GO:0050673 epithelial cell proliferation 49/982 437/18722 4.47809503501096e-07 0.000166841026447265 LAMB1/LAMC1/GJA1/LGR4/NR2F2/EGFR/NRP2/FGFR2/LGR5/KDM5B/ISL1/YAP1/FERMT1/NRP1/PTPRK/NFIB/MMP14/DLX6/TGFBR3/PPARG/MAGED1/PTN/NF1/B2M/ID1/MARVELD3/FLT1/CDKN1C/SERPINF1/DLX5/HRAS/ESRP2/CCND1/SPARC/PPARD/IFT74/CYBA/CDK6/NUPR1/GRN/BRCA2/WDR48/MTSS1/RICTOR/TCF7L2/PGF/BAD/NME1/PDPK1 49 GO:0048568 embryonic organ development 48/982 427/18722 5.44714842645402e-07 0.000189415507949228 FBN1/FBN2/NR2F2/PBX1/TEAD1/FGFR2/COBL/BMP7/NAGLU/SPINT1/YAP1/ATP6V1B1/EFEMP1/MMP14/DLX6/TEAD3/EPAS1/CHD7/FOLR1/MYO7A/SPINT2/RDH10/ADM/TRIOBP/DLX5/EFNA1/TFAP2A/TPRN/GLI3/TFEB/PHLDA2/CEBPA/FZD6/TBX3/PDGFA/NPHP3/SLC39A1/MFAP5/AHI1/SLC39A3/WDR48/INSIG1/TRIM28/RPL10/RAD23B/FOXC1/KRT8/RBPJ 48 GO:0016055 Wnt signaling pathway 49/982 444/18722 7.16826536806457e-07 0.000233685450998905 PLPP3/LGR4/KANK1/EGFR/WLS/LRP1/RNF43/AMOTL1/APP/LRP5/FZD10/FGFR2/LGR5/TPBG/ISL1/SOX4/YAP1/FERMT1/DVL3/RBMS3/AMOTL2/WNK2/DDB1/FOLR1/NOTUM/LRP6/ASPM/ZNRF3/LATS2/SPIN1/TSKU/DAB2/DLX5/GLI3/AXIN2/CCND1/CD24/TBL1X/FERMT2/FZD6/NPHP3/USP47/ATP6V1C2/FBXW4/CBY1/TCF7L2/CCNE1/VGLL4/RBPJ 49 GO:0198738 cell-cell signaling by wnt 49/982 446/18722 8.17888213754407e-07 0.000250947348408411 PLPP3/LGR4/KANK1/EGFR/WLS/LRP1/RNF43/AMOTL1/APP/LRP5/FZD10/FGFR2/LGR5/TPBG/ISL1/SOX4/YAP1/FERMT1/DVL3/RBMS3/AMOTL2/WNK2/DDB1/FOLR1/NOTUM/LRP6/ASPM/ZNRF3/LATS2/SPIN1/TSKU/DAB2/DLX5/GLI3/AXIN2/CCND1/CD24/TBL1X/FERMT2/FZD6/NPHP3/USP47/ATP6V1C2/FBXW4/CBY1/TCF7L2/CCNE1/VGLL4/RBPJ 49 GO:0044409 entry into host 24/982 151/18722 1.11815769795219e-06 0.0003240172529177 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/CTSL/CD46/LDLR/TRIM6/SLC1A5/P4HB/SLC52A2/ITGB1/NUP153/DPP4/SCARB2/BSG/GSN/TRIM27/EXOC2/F11R 24 GO:0001763 morphogenesis of a branching structure 28/982 196/18722 1.36068218500336e-06 0.000373543067209343 DAG1/LGR4/PBX1/MET/LRP5/FGFR2/TACSTD2/BMP7/KDM5B/LAMA5/SPINT1/YAP1/NRP1/MMP14/MAGED1/DLG5/SPINT2/RDH10/ADM/GLI3/ESRP2/TGM2/TBX3/PDGFA/MAP3K13/COL4A1/RERE/CLIC4 28 GO:0052126 movement in host environment 26/982 175/18722 1.52092632942033e-06 0.000396657586712822 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/DDB1/CTSL/CD46/LDLR/TRIM6/SLC1A5/P4HB/SLC52A2/ITGB1/NUP153/DPP4/TRIM28/SCARB2/BSG/GSN/TRIM27/EXOC2/F11R 26 GO:0001890 placenta development 23/982 144/18722 1.70572809391879e-06 0.000404412624449109 GJA1/NR2F2/CTSV/FGFR2/BMP7/SPINT1/MME/DLX3/PPARG/ITGB8/EPAS1/PTN/SPINT2/ADM/TFEB/PHLDA2/PTK2/CEBPA/PPARD/TRIM28/BSG/KRT8/RBPJ 23 GO:0046718 viral entry into host cell 23/982 144/18722 1.70572809391879e-06 0.000404412624449109 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/CTSL/CD46/LDLR/TRIM6/SLC1A5/P4HB/SLC52A2/ITGB1/NUP153/DPP4/SCARB2/BSG/GSN/TRIM27/F11R 23 GO:0007044 cell-substrate junction assembly 18/982 95/18722 1.86312703510709e-06 0.000422524809352982 ITGB4/LAMC1/DST/LRP1/PIP5K1A/ITGA6/SORBS1/NRP1/PTPRK/MMP14/EFNA5/CTTN/PTK2/ACTN1/TRIP6/FERMT2/MAP4K4/PDPK1 18 GO:0010232 vascular transport 17/982 88/18722 2.7103361490253e-06 0.000574168171964374 LRP2/GJA1/LRP1/SLC19A1/TFRC/SLC16A1/ABCG2/SLC16A12/SLC2A1/SLC1A3/SLC29A1/SLC13A3/SLC1A5/SLC44A1/SLC38A2/SLC7A2/SLC5A3 17 GO:0051701 biological process involved in interaction with host 28/982 203/18722 2.75195634568814e-06 0.000574168171964374 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/DDB1/CTSL/CD46/LDLR/TRIM6/SLC1A5/P4HB/RXRA/SLC52A2/ITGB1/NUP153/DPP4/TRIM28/SCARB2/BSG/GSN/TRIM27/RRAGA/EXOC2/F11R 28 GO:0061138 morphogenesis of a branching epithelium 26/982 182/18722 3.21290281242769e-06 0.000644557733447032 DAG1/LGR4/PBX1/MET/LRP5/FGFR2/TACSTD2/BMP7/KDM5B/LAMA5/SPINT1/YAP1/NRP1/MMP14/MAGED1/DLG5/SPINT2/RDH10/ADM/GLI3/ESRP2/TGM2/TBX3/PDGFA/COL4A1/CLIC4 26 GO:0048736 appendage development 25/982 172/18722 3.60351264457576e-06 0.000671282926932399 ITGB4/FBN2/NR2F2/PBX1/FRAS1/LRP5/FGFR2/BMP7/FREM2/ITGA6/SOX4/DLX6/CHD7/ZNRF3/RDH10/SMOC1/DLX5/TFAP2A/GLI3/FERMT2/FZD6/TBX3/SLC39A1/SLC39A3/FBXW4 25 GO:0060173 limb development 25/982 172/18722 3.60351264457576e-06 0.000671282926932399 ITGB4/FBN2/NR2F2/PBX1/FRAS1/LRP5/FGFR2/BMP7/FREM2/ITGA6/SOX4/DLX6/CHD7/ZNRF3/RDH10/SMOC1/DLX5/TFAP2A/GLI3/FERMT2/FZD6/TBX3/SLC39A1/SLC39A3/FBXW4 25 GO:0033627 cell adhesion mediated by integrin 15/982 72/18722 3.90203282481561e-06 0.000701827697042697 FBN1/ITGB4/PLPP3/ITGAV/ITGB5/FERMT1/SWAP70/ITGB8/JAM3/EFNA1/PTK2/IFT74/CCL5/ITGB1/DPP4 15 GO:0150115 cell-substrate junction organization 18/982 101/18722 4.64684763752488e-06 0.000807931909244325 ITGB4/LAMC1/DST/LRP1/PIP5K1A/ITGA6/SORBS1/NRP1/PTPRK/MMP14/EFNA5/CTTN/PTK2/ACTN1/TRIP6/FERMT2/MAP4K4/PDPK1 18 GO:0032970 regulation of actin filament-based process 43/982 396/18722 5.16733237420708e-06 0.000861795334873935 KANK1/MET/LRP1/FZD10/GJA5/TACSTD2/DSG2/KANK4/SCIN/DSP/DSC2/NRP1/RASA1/SWAP70/SYNPO/FER/EFNA5/JAM3/CYFIP1/PPP1R9A/ID1/CTTN/TMSB4X/TRIOBP/HRAS/RHOBTB3/TJP1/NCKAP1/WASL/RHOBTB1/FERMT2/EPS8/PDGFA/PPFIA1/PKP2/LIMA1/MTSS1/GSN/RICTOR/CD2AP/TRIM27/F11R/RND3 43 GO:0048732 gland development 46/982 436/18722 5.28708794401187e-06 0.000861795334873935 DAG1/CDH1/PBX1/EGFR/MET/PRLR/LSR/WLS/LRP5/FGFR2/COBL/BMP7/KDM5B/LAMA5/ISL1/ELF3/NRP1/NFIB/TGFBR3/PTN/NF1/SLC29A1/SERPINF1/HRAS/PRKCSH/GLI3/ESRP2/LMO4/CCND1/TGM2/CEBPA/KRT18/TBX3/PDGFA/NPHP3/PSAP/BRCA2/PPAT/ARHGAP5/IRS2/SEC63/CDO1/FOXC1/NME1/ASS1/RBPJ 46 GO:0060445 branching involved in salivary gland morphogenesis 8/982 21/18722 6.14281641146568e-06 0.000911928680304875 DAG1/FGFR2/BMP7/LAMA5/NRP1/ESRP2/TGM2/PDGFA 8 GO:0003279 cardiac septum development 18/982 103/18722 6.19279558074849e-06 0.000911928680304875 LRP2/NRP2/FGFR2/GJA5/ADAMTS6/BMP7/ISL1/SOX4/NRP1/TGFBR3/CHD7/CRELD1/LMO4/TBX3/MDM2/NPHP3/TRIP11/RBPJ 18 GO:0010639 negative regulation of organelle organization 39/982 347/18722 6.2594520563948e-06 0.000911928680304875 KANK1/MET/TACSTD2/BMP7/KANK4/SCIN/YAP1/TFRC/SWAP70/PPARG/ANKRD27/PPP1R9A/CENPF/TMSB4X/MCM2/TRIOBP/LIMK2/TJP1/ZWINT/SPDL1/HDAC6/CAMSAP2/EPS8/TRIAP1/PINK1/LMNA/TBC1D4/TRIM37/NUPR1/PPFIA1/TOP2A/LIMA1/TPX2/GSN/F11R/LCMT1/RAD50/HUWE1/PHF23 39 GO:0072659 protein localization to plasma membrane 34/982 284/18722 6.29398629044776e-06 0.000911928680304875 CDH1/EGFR/LRP1/PIP5K1A/TPBG/LAMA5/SORBS1/MMP14/TMEM150A/LRP6/DAB2/NSG1/PRKCI/MAP7/RAB13/CLN3/KRT18/CLTC/RAB31/RILPL1/PPFIA1/ITGB1/ZDHHC3/PKP2/GORASP2/EPB41L3/ANK3/BSG/FLOT2/LYPLA1/EHD3/ANXA2/F11R/PDPK1 34 GO:0030198 extracellular matrix organization 35/982 301/18722 8.82968606046096e-06 0.0012447470943612 LAMB1/COL14A1/ADAMTS1/LAMC1/CCDC80/DAG1/ADAMTSL4/ADAMTS19/COL4A2/LRP1/APP/VWA1/CTSV/ADAMTS6/ELF3/SPINT1/SERPINH1/FERMT1/MMP14/FBLN1/NF1/SPINT2/SMOC1/P3H4/MMP15/VIPAS39/ST7/ITGB1/COL4A1/PRDX4/CST3/DPP4/HSD17B12/FOXC1/ANXA2 35 GO:0043062 extracellular structure organization 35/982 302/18722 9.4965000027841e-06 0.00127415932764442 LAMB1/COL14A1/ADAMTS1/LAMC1/CCDC80/DAG1/ADAMTSL4/ADAMTS19/COL4A2/LRP1/APP/VWA1/CTSV/ADAMTS6/ELF3/SPINT1/SERPINH1/FERMT1/MMP14/FBLN1/NF1/SPINT2/SMOC1/P3H4/MMP15/VIPAS39/ST7/ITGB1/COL4A1/PRDX4/CST3/DPP4/HSD17B12/FOXC1/ANXA2 35 GO:0030111 regulation of Wnt signaling pathway 37/982 328/18722 9.89239744564856e-06 0.00127415932764442 PLPP3/LGR4/KANK1/EGFR/WLS/LRP1/RNF43/APP/FGFR2/LGR5/TPBG/ISL1/SOX4/YAP1/FERMT1/RBMS3/WNK2/FOLR1/NOTUM/ASPM/ZNRF3/LATS2/SPIN1/TSKU/DAB2/DLX5/GLI3/AXIN2/TBL1X/FZD6/NPHP3/USP47/ATP6V1C2/CBY1/TCF7L2/VGLL4/RBPJ 37 GO:0015711 organic anion transport 39/982 354/18722 1.00284243018187e-05 0.00127415932764442 LRP2/GJA1/SLC26A2/SLC35B4/SLC38A9/SLC19A1/SLC52A3/SLC16A1/ABCG2/SLC52A1/SLC16A12/SLC25A13/SLC4A2/FOLR1/PLEKHA8/SLC2A1/SLC1A3/SLC29A1/SLC43A2/SLC22A11/CYB5R1/SLC13A3/PTGES/PLA2G12A/SLC1A5/SLC25A4/CLN3/SLC25A1/SLC7A6/SLC16A4/SLC35B2/SLC25A17/SLC52A2/ITGB1/PSAP/SLC38A2/SLC35D1/SLC7A2/LRRC8D 39 GO:0034329 cell junction assembly 44/982 420/18722 1.00838910019122e-05 0.00127415932764442 ITGB4/PLXNB1/LAMC1/GJA1/CDH1/DST/OBSL1/LSR/LRP1/APP/VSTM5/GJA5/PIP5K1A/TPBG/ITGA6/SHANK2/SORBS1/NRP1/CLDN4/PTPRK/MMP14/DLG5/EFNA5/CLDN19/JAM3/PPP1R9A/CTTN/MARVELD3/PLXNB2/TJP1/PARD3/PTK2/RAB13/MPP7/ACTN1/TRIP6/FERMT2/MAP4K4/CLDN7/PKP2/EPB41L3/RAB17/F11R/PDPK1 44 GO:0150104 transport across blood-brain barrier 16/982 87/18722 1.02597185124742e-05 0.00127415932764442 LRP2/LRP1/SLC19A1/TFRC/SLC16A1/ABCG2/SLC16A12/SLC2A1/SLC1A3/SLC29A1/SLC13A3/SLC1A5/SLC44A1/SLC38A2/SLC7A2/SLC5A3 16 GO:0007229 integrin-mediated signaling pathway 18/982 107/18722 1.0738221464965e-05 0.00130054668403432 ITGB4/ADAMTS1/PLPP3/DST/ITGAV/LAMA5/ITGB5/ITGA6/FERMT1/NRP1/ITGB8/PTN/DOCK1/FUT8/PTK2/FERMT2/ITGB1/VAV3 18 GO:0045229 external encapsulating structure organization 35/982 304/18722 1.09708692671607e-05 0.00130054668403432 LAMB1/COL14A1/ADAMTS1/LAMC1/CCDC80/DAG1/ADAMTSL4/ADAMTS19/COL4A2/LRP1/APP/VWA1/CTSV/ADAMTS6/ELF3/SPINT1/SERPINH1/FERMT1/MMP14/FBLN1/NF1/SPINT2/SMOC1/P3H4/MMP15/VIPAS39/ST7/ITGB1/COL4A1/PRDX4/CST3/DPP4/HSD17B12/FOXC1/ANXA2 35 GO:0003205 cardiac chamber development 23/982 161/18722 1.16782624328554e-05 0.00135364037443942 LRP2/ADAMTS1/NRP2/FGFR2/GJA5/ADAMTS6/BMP7/DSP/ISL1/SOX4/NRP1/TGFBR3/CHD7/CRELD1/LMO4/TBX3/MDM2/NPHP3/PKP2/ADGRG6/FOXC1/TRIP11/RBPJ 23 GO:1990778 protein localization to cell periphery 37/982 333/18722 1.39075214635586e-05 0.0015769919989983 DAG1/CDH1/EGFR/LRP1/PIP5K1A/TPBG/LAMA5/SORBS1/MMP14/TMEM150A/LRP6/GNAI1/DAB2/HRAS/NSG1/PRKCI/MAP7/RAB13/CLN3/KRT18/CLTC/RAB31/RILPL1/PPFIA1/ITGB1/ZDHHC3/PKP2/GORASP2/EPB41L3/ANK3/BSG/FLOT2/LYPLA1/EHD3/ANXA2/F11R/PDPK1 37 GO:0061564 axon development 47/982 467/18722 1.46049036610775e-05 0.00159726033677086 PLXNB1/DAG1/SEMA6D/SEMA6A/LRP1/APP/NRP2/FGFR2/COBL/BMP7/NOTCH3/LAMA5/ISL1/NREP/NRP1/NFIB/SEMA3F/SEMA4C/FOLR1/PTN/SIAH1/EFNA5/JAM3/CYFIP1/TNFRSF21/CTTN/ALS2/TSKU/DLX5/EFNA1/PLXNB2/EPHB4/PTPRF/GLI3/PARD3/PTK2/HDAC6/CAMSAP2/DPYSL2/MAP3K13/SLC25A46/ITGB1/GRN/AFG3L2/ANK3/ENAH/BSG 47 GO:0007179 transforming growth factor beta receptor signaling pathway 26/982 198/18722 1.51089601923141e-05 0.00159726033677086 FBN1/FBN2/ITGB5/LTBP1/NREP/FERMT1/RASL11B/PTPRK/GCNT2/TGFBR3/PPARG/ITGB8/FOLR1/PEG10/ID1/LATS2/FUT8/DAB2/CDKN1C/PTK2/MAP3K7/FERMT2/ZNF451/GLG1/SMAD5/PDPK1 26 GO:0031099 regeneration 26/982 198/18722 1.51089601923141e-05 0.00159726033677086 DAG1/EGFR/LRP1/ISL1/NREP/YAP1/TGFBR3/FOLR1/PTN/JAM3/ADM/PTPRF/GLI3/CCND1/PPARD/MAP4K4/GSTP1/GRN/BIN3/PPAT/CPQ/PGF/KLF5/CCNA2/ANXA3/ATIC 26 GO:0035272 exocrine system development 11/982 45/18722 1.53111612037084e-05 0.00159726033677086 DAG1/WLS/FGFR2/BMP7/LAMA5/NRP1/NFIB/ESRP2/TGM2/PDGFA/FOXC1 11 GO:0050680 negative regulation of epithelial cell proliferation 23/982 164/18722 1.58697644834981e-05 0.00162307238325345 GJA1/NR2F2/FGFR2/ISL1/PTPRK/NFIB/TGFBR3/PPARG/MAGED1/PTN/NF1/B2M/MARVELD3/FLT1/CDKN1C/SERPINF1/SPARC/PPARD/IFT74/CDK6/NUPR1/BRCA2/MTSS1 23 GO:0048839 inner ear development 25/982 188/18722 1.76130756266669e-05 0.00176672697055182 MCOLN3/FGFR2/LGR5/FREM2/NAGLU/ATP6V1B1/DLX6/CHD7/MYO7A/MCM2/ESRP1/TSKU/TRIOBP/DLX5/TFAP2A/TPRN/GLI3/CEBPA/SPARC/FZD6/AHI1/INSIG1/TRIP11/CCNA2/RBPJ 25 GO:0045216 cell-cell junction organization 26/982 200/18722 1.8074048196571e-05 0.00177875915836442 SVEP1/GJA1/CDH1/LSR/GJA5/DSG2/DSP/CLDN4/DLG5/CLDN19/JAM3/PERP/MARVELD3/PRKCI/TJP1/TJP2/PARD3/RAB13/MPP7/FERMT2/KIFC3/CLDN7/PKP2/EPB41L3/MTSS1/F11R 26 GO:0003018 vascular process in circulatory system 31/982 263/18722 2.16804685629897e-05 0.00209417266712137 LRP2/GJA1/EGFR/SLC6A4/LRP1/ADRB1/GJA5/SLC19A1/TFRC/SLC16A1/ABCG2/SLC16A12/SLC2A1/SLC1A3/ADM/SLC29A1/ATP2B1/TJP1/TJP2/SLC13A3/SLC1A5/YES1/SLC44A1/FERMT2/PPARD/SLC38A2/EXT2/GCLM/SLC7A2/FOXC1/SLC5A3 31 GO:0048880 sensory system development 40/982 381/18722 2.40208496215452e-05 0.00227805002956327 FBN1/FBN2/TENM3/PBX1/OBSL1/LRP5/BMP7/KDM5B/FREM2/ISL1/NAGLU/NHS/EFEMP1/NRP1/CHD7/PTN/NF1/FAT1/MYO7A/ACVR2B/RDH10/SMOC1/TSKU/LIMK2/FLT1/SERPINF1/PRKCI/ATP2B1/TFAP2A/GLI3/BCAR3/MFAP5/COL4A1/AHI1/IMPDH2/TUG1/FOXC1/CLIC4/VIM/RRM1 40 GO:0060485 mesenchyme development 33/982 291/18722 2.64400494632665e-05 0.00240398843313291 DAG1/SEMA6D/SEMA6A/NRP2/FGFR2/BMP7/LAMA5/ISL1/YAP1/NRP1/SEMA3F/GCNT2/TGFBR3/SEMA4C/FOLR1/CRELD1/DLG5/LRP6/RDH10/DAB2/EFNA1/AXIN2/BASP1/DPPA4/S100A4/FERMT2/TBX3/MDM2/TRIM28/FOXC1/TCF7L2/ZNF750/RBPJ 33 GO:0045785 positive regulation of cell adhesion 44/982 437/18722 2.6903695304052e-05 0.00240398843313291 CCDC80/DAG1/PLPP3/ITGAV/KIF26B/BMP7/ITGA6/ZFHX3/SOX4/TFRC/FERMT1/NRP1/GCNT2/IL6ST/GPAM/PTN/ADGRG1/DOCK1/B2M/CD46/HLA-A/TRIOBP/TJP1/NFAT5/GLI3/YES1/TGM2/CD24/HLA-E/FERMT2/P4HB/IFT74/CCL5/CDK6/MAP4K4/CYTH3/ANK3/VAV3/DPP4/FLOT2/HSD17B12/BAD/F11R/BCL10 44 GO:0006487 protein N-linked glycosylation 13/982 65/18722 2.7118552560562e-05 0.00240398843313291 MGAT3/TUSC3/MOGS/ALG6/UGGT2/DPAGT1/FUT8/STT3A/GFPT1/PMM2/RPN2/EXT2/DDOST 13 GO:0007435 salivary gland morphogenesis 9/982 32/18722 2.71923538256981e-05 0.00240398843313291 DAG1/FGFR2/BMP7/LAMA5/NRP1/NFIB/ESRP2/TGM2/PDGFA 9 GO:0032956 regulation of actin cytoskeleton organization 38/982 357/18722 2.81351758626616e-05 0.00244588462166072 KANK1/MET/LRP1/FZD10/TACSTD2/KANK4/SCIN/NRP1/RASA1/SWAP70/SYNPO/FER/EFNA5/JAM3/CYFIP1/PPP1R9A/ID1/CTTN/TMSB4X/TRIOBP/HRAS/RHOBTB3/TJP1/NCKAP1/WASL/RHOBTB1/FERMT2/EPS8/PDGFA/PPFIA1/LIMA1/MTSS1/GSN/RICTOR/CD2AP/TRIM27/F11R/RND3 38 GO:0001654 eye development 39/982 371/18722 2.93904102888926e-05 0.00251312098470269 FBN1/FBN2/TENM3/PBX1/OBSL1/LRP5/BMP7/KDM5B/FREM2/NAGLU/NHS/EFEMP1/NRP1/CHD7/PTN/NF1/FAT1/MYO7A/ACVR2B/RDH10/SMOC1/TSKU/LIMK2/FLT1/SERPINF1/PRKCI/ATP2B1/TFAP2A/GLI3/BCAR3/MFAP5/COL4A1/AHI1/IMPDH2/TUG1/FOXC1/CLIC4/VIM/RRM1 39 GO:0048863 stem cell differentiation 26/982 206/18722 3.04040103831053e-05 0.0025578599702948 SEMA6D/SEMA6A/NRP2/FGFR2/TACSTD2/BMP7/LAMA5/ISL1/YAP1/NRP1/SEMA3F/SEMA4C/FOLR1/PTN/LRP6/RDH10/MSI2/TRIM6/FOXO4/PUM1/KRT18/YTHDF2/METTL3/FOXC1/ZNF281/RBPJ 26 GO:0071559 response to transforming growth factor beta 30/982 256/18722 3.26865229875921e-05 0.00270623656989334 FBN1/FBN2/COL4A2/FGFR2/ITGB5/LTBP1/NREP/ZFHX3/FERMT1/RASL11B/PTPRK/GCNT2/TGFBR3/PPARG/ITGB8/FOLR1/PEG10/ID1/LATS2/FUT8/DAB2/CDKN1C/YES1/PTK2/MAP3K7/FERMT2/ZNF451/GLG1/SMAD5/PDPK1 30 GO:0009100 glycoprotein metabolic process 40/982 387/18722 3.43096945255797e-05 0.00279624010383475 EXTL2/CHPF/MGAT3/GPC1/TUSC3/MOGS/GALNT18/PAWR/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/CTSL/DPAGT1/FUT8/GALNT11/B3GNT3/DSEL/PRKCSH/B4GAT1/GLCE/TET2/STT3A/PPARD/GFPT1/XYLT1/MANBA/PMM2/CST3/RPN2/EXT2/ST3GAL6/TCF7L2/TRIP11/DDOST/BACE2/GANAB/ITM2C 40 GO:0150063 visual system development 39/982 375/18722 3.73430885589808e-05 0.00295299810892978 FBN1/FBN2/TENM3/PBX1/OBSL1/LRP5/BMP7/KDM5B/FREM2/NAGLU/NHS/EFEMP1/NRP1/CHD7/PTN/NF1/FAT1/MYO7A/ACVR2B/RDH10/SMOC1/TSKU/LIMK2/FLT1/SERPINF1/PRKCI/ATP2B1/TFAP2A/GLI3/BCAR3/MFAP5/COL4A1/AHI1/IMPDH2/TUG1/FOXC1/CLIC4/VIM/RRM1 39 GO:0051960 regulation of nervous system development 44/982 443/18722 3.73653901820102e-05 0.00295299810892978 LRP2/PLXNB1/DAG1/SEMA6D/SEMA6A/EGFR/OBSL1/LRP1/BHLHE41/PRTG/VSTM5/BMP7/TPBG/ETV5/SPINT1/YAP1/MME/NRP1/SEMA3F/IL6ST/SEMA4C/ANKRD27/CUX1/CHD7/PTN/NF1/DLG5/ASPM/CYFIP1/B2M/TNFRSF21/ID1/LDLR/SERPINF1/PRKCI/PLXNB2/SYNJ1/GLI3/PARD3/TGM2/HOOK3/YTHDF2/MAP3K13/NPHP3 44 GO:0048754 branching morphogenesis of an epithelial tube 21/982 151/18722 4.15449833776925e-05 0.0032343079596723 DAG1/LGR4/PBX1/MET/LRP5/FGFR2/TACSTD2/BMP7/KDM5B/LAMA5/YAP1/NRP1/MMP14/MAGED1/DLG5/RDH10/GLI3/ESRP2/TBX3/COL4A1/CLIC4 21 GO:0050767 regulation of neurogenesis 38/982 364/18722 4.30725457677695e-05 0.0033039176283042 LRP2/PLXNB1/DAG1/SEMA6D/SEMA6A/EGFR/OBSL1/LRP1/BHLHE41/PRTG/BMP7/ETV5/SPINT1/YAP1/MME/NRP1/SEMA3F/IL6ST/SEMA4C/ANKRD27/CUX1/CHD7/PTN/NF1/ASPM/CYFIP1/B2M/ID1/LDLR/SERPINF1/PRKCI/PLXNB2/SYNJ1/GLI3/TGM2/HOOK3/YTHDF2/MAP3K13 38 GO:0007431 salivary gland development 9/982 34/18722 4.62543674212677e-05 0.00349656203578742 DAG1/FGFR2/BMP7/LAMA5/NRP1/NFIB/ESRP2/TGM2/PDGFA 9 GO:0048762 mesenchymal cell differentiation 28/982 236/18722 4.74447443447104e-05 0.00353531123574299 DAG1/SEMA6D/SEMA6A/NRP2/FGFR2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/GCNT2/TGFBR3/SEMA4C/FOLR1/DLG5/LRP6/RDH10/DAB2/EFNA1/AXIN2/S100A4/FERMT2/TBX3/TRIM28/FOXC1/TCF7L2/ZNF750/RBPJ 28 GO:0001503 ossification 41/982 408/18722 5.23629255257617e-05 0.00383752204277057 FBN2/PLXNB1/LGR4/PBX1/EGFR/SLC26A2/LRP5/FGFR2/BMP7/RRBP1/YAP1/ATP6V1B1/MMP14/PPARG/IL6ST/PTN/NOTUM/NF1/ACVR2B/SMOC1/DLX5/ATP2B1/TFAP2A/GLI3/AXIN2/RDH14/PTK2/CEBPA/CRIM1/FERMT2/SPARC/ESRRA/CLTC/CDK6/XYLT1/DHX9/EXT2/INPPL1/SMAD5/FOXC1/RBPJ 41 GO:0071560 cellular response to transforming growth factor beta stimulus 29/982 250/18722 5.29719300382441e-05 0.00383752204277057 FBN1/FBN2/COL4A2/FGFR2/ITGB5/LTBP1/NREP/FERMT1/RASL11B/PTPRK/GCNT2/TGFBR3/PPARG/ITGB8/FOLR1/PEG10/ID1/LATS2/FUT8/DAB2/CDKN1C/YES1/PTK2/MAP3K7/FERMT2/ZNF451/GLG1/SMAD5/PDPK1 29 GO:0043583 ear development 26/982 213/18722 5.40515335234315e-05 0.00386209313504409 MCOLN3/FGFR2/LGR5/FREM2/NAGLU/ATP6V1B1/DLX6/CHD7/MYO7A/RDH10/MCM2/ESRP1/TSKU/TRIOBP/DLX5/TFAP2A/TPRN/GLI3/CEBPA/SPARC/FZD6/AHI1/INSIG1/TRIP11/CCNA2/RBPJ 26 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 37/982 355/18722 5.59622283078954e-05 0.00394458084937814 LRP2/FBN1/FBN2/LRP1/BMP7/ITGB5/LTBP1/NREP/FERMT1/RASL11B/PTPRK/GCNT2/TGFBR3/PPARG/ITGB8/FOLR1/ACVR2B/PEG10/ID1/LATS2/RBPMS/FUT8/DAB2/CDKN1C/DLX5/DACT2/PTK2/MAP3K7/CRIM1/FERMT2/ZNF451/FSTL1/GLG1/SMAD5/VIM/PDPK1/RBPJ 37 GO:0060070 canonical Wnt signaling pathway 33/982 303/18722 5.93105687670202e-05 0.00407461880839004 PLPP3/LGR4/KANK1/EGFR/WLS/LRP5/FZD10/FGFR2/LGR5/TPBG/ISL1/SOX4/YAP1/FERMT1/DVL3/RBMS3/WNK2/FOLR1/NOTUM/LRP6/ASPM/ZNRF3/LATS2/DAB2/DLX5/GLI3/AXIN2/TBL1X/FZD6/NPHP3/USP47/TCF7L2/RBPJ 33 GO:0044403 biological process involved in symbiotic interaction 32/982 290/18722 5.9369445827769e-05 0.00407461880839004 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/EIF2AK4/DDB1/CTSL/CD46/LDLR/TRIM6/SLC1A5/TARDBP/P4HB/CCL5/RXRA/SLC52A2/ITGB1/NUP153/DPP4/TRIM28/SCARB2/BSG/GSN/TRIM27/RRAGA/EXOC2/F11R/TAF11 32 GO:0007411 axon guidance 27/982 227/18722 6.15913929055175e-05 0.00417221695318414 PLXNB1/DAG1/SEMA6D/SEMA6A/LRP1/APP/NRP2/BMP7/NOTCH3/LAMA5/ISL1/NRP1/NFIB/SEMA3F/SEMA4C/SIAH1/EFNA5/CYFIP1/DLX5/EFNA1/PLXNB2/EPHB4/GLI3/PTK2/DPYSL2/ENAH/BSG 27 GO:0150105 protein localization to cell-cell junction 7/982 21/18722 6.49697061672228e-05 0.00434464086369531 LSR/DSP/DLG5/TJP1/TJP2/MPP7/F11R 7 GO:0097485 neuron projection guidance 27/982 228/18722 6.64567437143139e-05 0.00438782753435267 PLXNB1/DAG1/SEMA6D/SEMA6A/LRP1/APP/NRP2/BMP7/NOTCH3/LAMA5/ISL1/NRP1/NFIB/SEMA3F/SEMA4C/SIAH1/EFNA5/CYFIP1/DLX5/EFNA1/PLXNB2/EPHB4/GLI3/PTK2/DPYSL2/ENAH/BSG 27 GO:0043434 response to peptide hormone 41/982 414/18722 7.26310365492944e-05 0.004735543583014 FBN1/GJA1/DAG1/KANK1/LRP5/BMP7/SORBS1/TGFBR3/PPARG/FER/SLC2A1/LRP6/CYFIP1/GAB1/GNAI1/ADM/IGF1R/PRKCI/ATP2B1/FOXO4/PTK2/RAB13/CYC1/SPARC/ESRRA/BCAR3/MDM2/CYBA/TBC1D4/RAB31/GSTP1/PPAT/INSIG1/IRS2/INPPL1/BSG/LEPROT/CDO1/PDPK1/CCNA2/ASS1 41 GO:0051017 actin filament bundle assembly 21/982 157/18722 7.41148786944292e-05 0.00477263218852028 MET/TACSTD2/ITGB5/PAWR/SORBS1/NRP1/SWAP70/SYNPO/PPP1R9A/ID1/CALD1/TJP1/PDLIM1/ACTN1/FERMT2/EPS8/PPFIA1/LIMA1/MTSS1/HSP90B1/F11R 21 GO:1904350 regulation of protein catabolic process in the vacuole 5/982 10/18722 7.93737866463815e-05 0.00504894720911617 LRP2/LRP1/MGAT3/LDLR/RNF128 5 GO:0090596 sensory organ morphogenesis 29/982 256/18722 8.12990340100379e-05 0.00510910555899226 FBN1/FBN2/TENM3/OBSL1/LRP5/FGFR2/BMP7/NAGLU/ATP6V1B1/EFEMP1/DLX6/CHD7/PTN/NF1/FAT1/MYO7A/TSKU/TRIOBP/DLX5/PRKCI/TFAP2A/TPRN/GLI3/FZD6/BCAR3/MFAP5/AHI1/INSIG1/TUG1 29 GO:0016331 morphogenesis of embryonic epithelium 20/982 147/18722 8.58013979634296e-05 0.00532785823544344 LRP2/IRX2/FGFR2/COBL/BMP7/LAMA5/SPINT1/SOX4/DVL3/SEMA4C/FOLR1/SPINT2/RDH10/ADM/PLXNB2/TFAP2A/LMO4/FZD6/NPHP3/BCL10 20 GO:0060349 bone morphogenesis 15/982 93/18722 9.42393581660176e-05 0.00572641201050223 LRP5/FGFR2/SERPINH1/MMP14/TSKU/DLX5/TFAP2A/GLI3/AXIN2/INSIG1/EXT2/INPPL1/GLG1/FOXC1/TRIP11 15 GO:0035148 tube formation 20/982 148/18722 9.44155354492316e-05 0.00572641201050223 LRP2/IRX2/FGFR2/COBL/BMP7/SPINT1/SOX4/DVL3/NFIB/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/TGM2/FZD6/NPHP3/SDCCAG8/BCL10 20 GO:0007160 cell-matrix adhesion 27/982 233/18722 9.63593605774882e-05 0.00577713131922044 ITGB4/DAG1/ITGAV/LRP1/BCAM/SGCE/PIP5K1A/ITGB5/FERMT1/SORBS1/NRP1/RASA1/PTPRK/MMP14/NF1/EFNA5/JAM3/CTTN/PTK2/ACTN1/TRIP6/FERMT2/CDK6/MAP4K4/PPFIA1/ITGB1/PDPK1 27 GO:0061572 actin filament bundle organization 21/982 161/18722 0.000106904754648474 0.00633653636643682 MET/TACSTD2/ITGB5/PAWR/SORBS1/NRP1/SWAP70/SYNPO/PPP1R9A/ID1/CALD1/TJP1/PDLIM1/ACTN1/FERMT2/EPS8/PPFIA1/LIMA1/MTSS1/HSP90B1/F11R 21 GO:0003229 ventricular cardiac muscle tissue development 11/982 55/18722 0.000111606014252405 0.00649575552267255 LRP2/FGFR2/DSG2/DSP/ISL1/TGFBR3/CHD7/TBX3/PKP2/FOXC1/RBPJ 11 GO:0007623 circadian rhythm 25/982 210/18722 0.000112081671211758 0.00649575552267255 LGR4/EGFR/SLC6A4/ADRB1/BHLHE41/NAGLU/ZFHX3/CLDN4/PPARG/DDB1/MAGED1/GNA11/ID1/TARDBP/PHLPP1/GFPT1/PSPC1/TOP2A/METTL3/NR2F6/IMPDH2/TOP1/OPN3/ASS1/HUWE1 25 GO:0048592 eye morphogenesis 20/982 151/18722 0.00012502826458854 0.00716645525377829 FBN1/FBN2/TENM3/OBSL1/LRP5/BMP7/NAGLU/EFEMP1/PTN/NF1/FAT1/MYO7A/TSKU/PRKCI/TFAP2A/GLI3/BCAR3/MFAP5/AHI1/TUG1 20 GO:0001656 metanephros development 14/982 85/18722 0.000126858545166612 0.00719232795205487 FBN1/LGR4/FRAS1/IRX2/KIF26B/BMP7/YAP1/NF1/DLG5/RDH10/GLI3/BASP1/PDGFA/AKR1B1 14 GO:0009101 glycoprotein biosynthetic process 33/982 317/18722 0.000141608301943735 0.00794224626815612 EXTL2/CHPF/MGAT3/TUSC3/MOGS/GALNT18/PAWR/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/DPAGT1/FUT8/GALNT11/B3GNT3/DSEL/B4GAT1/GLCE/TET2/STT3A/GFPT1/XYLT1/PMM2/RPN2/EXT2/ST3GAL6/TCF7L2/TRIP11/DDOST/BACE2/ITM2C 33 GO:0034446 substrate adhesion-dependent cell spreading 16/982 108/18722 0.000157189766789865 0.00872235982527588 LAMB1/LAMC1/KANK1/ITGAV/TACSTD2/LAMA5/NRP1/FBLN1/FER/EFNA5/DOCK1/TRIOBP/EFNA1/PTK2/FERMT2/P4HB 16 GO:0060828 regulation of canonical Wnt signaling pathway 28/982 253/18722 0.000159655777490305 0.00876594247778348 LGR4/KANK1/EGFR/WLS/FGFR2/LGR5/TPBG/ISL1/SOX4/YAP1/FERMT1/RBMS3/WNK2/FOLR1/NOTUM/ASPM/ZNRF3/LATS2/DAB2/DLX5/GLI3/AXIN2/TBL1X/FZD6/NPHP3/USP47/TCF7L2/RBPJ 28 GO:0048041 focal adhesion assembly 14/982 87/18722 0.000163839574352372 0.0089019502064789 LRP1/PIP5K1A/SORBS1/NRP1/PTPRK/MMP14/EFNA5/CTTN/PTK2/ACTN1/TRIP6/FERMT2/MAP4K4/PDPK1 14 GO:0021675 nerve development 13/982 77/18722 0.000169498110460406 0.00902603695762917 DAG1/NRP2/CTSV/ISL1/NRP1/SEMA3F/CHD7/SLC1A3/ERBB3/TFAP2A/GLI3/NAV2/AFG3L2 13 GO:0060541 respiratory system development 24/982 203/18722 0.000169584283329689 0.00902603695762917 DAG1/EGFR/FGFR2/LAMA5/YAP1/MME/NFIB/MMP14/EPAS1/CHD7/PTN/DLG5/RDH10/DLX5/GLI3/ESRP2/BASP1/CEBPA/DPPA4/SPARC/PDGFA/NPHP3/ASS1/RBPJ 24 GO:0001666 response to hypoxia 32/982 307/18722 0.000173393403261552 0.00913555546881066 SLC6A4/BMP7/PLOD2/MMP14/TGFBR3/EPAS1/PTN/NF1/SLC2A1/ALAD/ADM/MIEF1/SLC29A1/ADSL/PDLIM1/CD24/HILPDA/SLC11A2/P4HB/TM9SF4/PPARD/MDM2/CYBA/PINK1/LMNA/MALAT1/DPP4/HSP90B1/PGF/BAD/CCNA2/RBPJ 32 GO:0071526 semaphorin-plexin signaling pathway 9/982 40/18722 0.000181606947015253 0.0094726183563156 PLXNB1/SEMA6D/SEMA6A/MET/NRP2/NRP1/SEMA3F/SEMA4C/PLXNB2 9 GO:0045667 regulation of osteoblast differentiation 18/982 132/18722 0.000185001059573213 0.00955411412607801 FBN2/LRP5/FGFR2/BMP7/YAP1/PPARG/IL6ST/ACVR2B/SMOC1/GLI3/AXIN2/PTK2/CEBPA/CRIM1/FERMT2/ESRRA/CDK6/SMAD5 18 GO:0001704 formation of primary germ layer 17/982 121/18722 0.000192095444733287 0.00969680690926762 LAMB1/ITGB4/GJA1/ITGAV/COL4A2/WLS/FGFR2/BMP7/ITGB5/MMP14/KIF16B/MMP15/DUSP5/ITGB1/EXT2/FOXC1/TXNRD1 17 GO:0003206 cardiac chamber morphogenesis 17/982 121/18722 0.000192095444733287 0.00969680690926762 LRP2/ADAMTS1/NRP2/FGFR2/BMP7/DSP/ISL1/SOX4/NRP1/TGFBR3/CHD7/TBX3/MDM2/PKP2/ADGRG6/FOXC1/RBPJ 17 GO:0060411 cardiac septum morphogenesis 12/982 68/18722 0.000194365324699222 0.00969680690926762 LRP2/NRP2/FGFR2/BMP7/ISL1/SOX4/NRP1/TGFBR3/CHD7/TBX3/MDM2/RBPJ 12 GO:0022604 regulation of cell morphogenesis 32/982 309/18722 0.000195252530309945 0.00969680690926762 PLXNB1/DAG1/KANK1/MYH10/OBSL1/TACSTD2/DVL3/NRP1/RASA1/CLDN4/FBLN1/ANKRD27/CUX1/PTN/EFNA5/CYFIP1/DOCK1/TRIOBP/PLXNB2/RHOBTB3/PTK2/SH3D19/RHOBTB1/FERMT2/P4HB/EPS8/FMNL2/SPARC/MAP3K13/EPB41L3/F11R/RND3 32 GO:0060348 bone development 24/982 205/18722 0.000197059342864718 0.00969680690926762 FBN1/PLXNB1/GJA1/LRP5/FGFR2/SERPINH1/MMP14/NOTUM/TSKU/DLX5/TFAP2A/HSD17B1/GLI3/AXIN2/TGM2/XYLT1/INSIG1/EXT2/INPPL1/GLG1/SMAD5/FOXC1/ANXA2/TRIP11 24 GO:0006898 receptor-mediated endocytosis 27/982 244/18722 0.000207992252984117 0.0101391363697678 LRP2/ITGAV/LRP1/TFRC/FOLR1/LRP6/B2M/ADM/CTTN/CTSL/DAB2/LDLR/AP2A2/SYNJ1/WASL/FNBP1L/CLN3/MICALL1/AP1S1/CLTC/RAB31/ITGB1/AHI1/SCARB2/CD2AP/RABEPK/ANXA2 27 GO:0030900 forebrain development 37/982 379/18722 0.000213752846542905 0.0103234708108129 LAMB1/LRP2/CDH1/NR2F2/LRP1/TACC2/APP/NRP2/FGFR2/ISL1/NRP1/NFIB/PGAP1/CHD7/PTN/NF1/ADGRG1/SLC2A1/ASPM/B2M/BTBD3/TSKU/GNG12/DLX5/GLI3/TBX3/HOOK3/CDK6/UBA6/SLC38A2/METTL3/BAD/NME1/ANXA3/ATIC/RBPJ/RRM1 37 GO:0071634 regulation of transforming growth factor beta production 9/982 41/18722 0.000221966668161264 0.0106218178085243 ITGAV/CD200/LTBP1/FERMT1/ITGB8/CD46/TSKU/CD24/CD2AP 9 GO:0042060 wound healing 40/982 422/18722 0.000224503241781906 0.0106455355375857 F5/GJA1/DAG1/PLPP3/KANK1/DST/EGFR/FGFR2/DSP/SYT7/YAP1/FERMT1/UBASH3B/GNA12/CLDN4/DCBLD2/FBLN1/IL6ST/NF1/LMAN1/CLDN19/ERBB3/TSKU/HRAS/GLI3/PTK2/MYOF/FERMT2/ANXA5/SPARC/FZD6/PPARD/C1QTNF1/PDGFA/CD59/ITGB1/HPS5/VAV3/ANXA2/F11R 40 GO:0050679 positive regulation of epithelial cell proliferation 24/982 207/18722 0.000228403343161054 0.0107328994407933 LAMB1/LAMC1/EGFR/NRP2/FGFR2/KDM5B/YAP1/NRP1/DLX6/PTN/ID1/DLX5/HRAS/ESRP2/CCND1/CYBA/GRN/WDR48/RICTOR/TCF7L2/PGF/BAD/NME1/PDPK1 24 GO:0002064 epithelial cell development 25/982 220/18722 0.000233745103294102 0.0108858433819825 ADAMTSL4/MET/YAP1/IL6ST/FAT1/MYO7A/SPINT2/TRIOBP/TJP1/TJP2/TPRN/DACT2/EXPH5/RAB13/IFT74/CDK6/FLNB/RILPL1/AKR1B1/CLIC4/BAD/KLF5/VIM/F11R/PDPK1 25 GO:0003007 heart morphogenesis 27/982 246/18722 0.000237623449696961 0.0109685302090208 LRP2/ADAMTS1/NRP2/FGFR2/GJA5/BMP7/DSP/ISL1/SOX4/YAP1/GAA/NRP1/TGFBR3/CHD7/FOLR1/EFNA1/EPHB4/AXIN2/PTK2/TBX3/MDM2/NPHP3/PKP2/AHI1/ADGRG6/FOXC1/RBPJ 27 GO:0031102 neuron projection regeneration 11/982 60/18722 0.000251556833546402 0.0115098284541933 DAG1/LRP1/ISL1/NREP/FOLR1/PTN/JAM3/ADM/PTPRF/MAP4K4/GRN 11 GO:0042063 gliogenesis 31/982 301/18722 0.000269021676015101 0.0121941224029541 LAMB1/LRP2/ITGB4/DAG1/EGFR/LRP1/APP/GPC1/ETV5/SPINT1/SOX4/NFIB/MMP14/IL6ST/PTN/NF1/ADGRG1/TNFRSF21/ERBB3/LDLR/PRKCI/SYNJ1/GLI3/PARD3/CDK6/GSTP1/ADGRG6/GRN/METTL3/VIM/BACE2 31 GO:0001841 neural tube formation 15/982 102/18722 0.000271188304973672 0.0121941224029541 LRP2/COBL/BMP7/SPINT1/SOX4/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 15 GO:0051056 regulation of small GTPase mediated signal transduction 31/982 302/18722 0.000285151557132595 0.0127123976239625 KANK1/NET1/ITGAV/ARHGAP23/MET/PLEKHG4B/SYDE2/ARHGAP32/NRP1/RASA1/SWAP70/AMOT/ADGRG1/FAM13A/ALS2/HRAS/ARHGAP21/ARHGEF11/TGM2/EPS8/RACGAP1/EPS8L2/MAP4K4/CYTH3/ITGB1/PPP2CB/ARHGAP5/VAV3/STAMBP/CD2AP/F11R 31 GO:0034113 heterotypic cell-cell adhesion 11/982 61/18722 0.00029256074348828 0.0129321765935158 ITGAV/CD200/DSG2/BMP7/DSP/DSC2/GCNT2/JAM3/PERP/ITGB1/PKP2 11 GO:0051222 positive regulation of protein transport 31/982 303/18722 0.000302135856040222 0.0132431985303008 GJA1/CDH1/EGFR/MYH10/WLS/LRP1/TCAF1/ISL1/SOX4/FRMD4A/TMEM30B/MIEF1/HRAS/GLI3/KCNN4/EXPH5/CLN3/TARDBP/TM9SF4/PPARD/MDM2/PINK1/TM7SF3/ANK3/IRS2/TRIM28/CD2AP/LEPROT/TCF7L2/BAD/HUWE1 31 GO:0043588 skin development 28/982 263/18722 0.000304889093396238 0.0132525125929565 ITGB4/LGR4/EGFR/FRAS1/MET/LSR/FGFR2/PIP5K1A/LGR5/LAMA5/DSP/ITGA6/YAP1/FERMT1/CLDN4/DACT2/DHCR24/EXPH5/NCOA3/FZD6/IFT74/PDGFA/FLNB/WDR48/FOXC1/OPN3/CLIC4/RBPJ 28 GO:0007039 protein catabolic process in the vacuole 6/982 19/18722 0.000308382035452366 0.0132935594786739 LRP2/LRP1/MGAT3/LDLR/RNF128/CLN3 6 GO:0021545 cranial nerve development 10/982 52/18722 0.000318453746655981 0.0134604513564575 NRP2/ISL1/NRP1/SEMA3F/CHD7/SLC1A3/ERBB3/TFAP2A/GLI3/NAV2 10 GO:1901653 cellular response to peptide 35/982 359/18722 0.00032121159607102 0.0134604513564575 FBN1/GJA1/KANK1/LRP1/APP/SORBS1/PPARG/FER/CYFIP1/GAB1/ID1/IGF1R/PRKCI/ATP2B1/FOXO4/PTK2/RAB13/ESRRA/BCAR3/MDM2/CYBA/TBC1D4/LGMN/RAB31/GSTP1/PPAT/INSIG1/IRS2/AKR1B1/LEPROT/KLF5/VIM/PDPK1/CCNA2/ASS1 35 GO:0001892 embryonic placenta development 13/982 82/18722 0.000323080033766782 0.0134604513564575 NR2F2/FGFR2/BMP7/SPINT1/EPAS1/SPINT2/ADM/TFEB/PHLDA2/CEBPA/TRIM28/KRT8/RBPJ 13 GO:0014002 astrocyte development 9/982 43/18722 0.000325156608687433 0.0134604513564575 EGFR/LRP1/APP/NF1/LDLR/CDK6/GRN/VIM/BACE2 9 GO:0071604 transforming growth factor beta production 9/982 43/18722 0.000325156608687433 0.0134604513564575 ITGAV/CD200/LTBP1/FERMT1/ITGB8/CD46/TSKU/CD24/CD2AP 9 GO:0060993 kidney morphogenesis 14/982 93/18722 0.000335658632076363 0.0137857907473253 LGR4/PBX1/FRAS1/IRX2/KIF26B/TACSTD2/BMP7/LAMA5/SOX4/MAGED1/GLI3/BASP1/NPHP3/AHI1 14 GO:1905475 regulation of protein localization to membrane 21/982 175/18722 0.000344912482331519 0.0139268963312898 DAG1/EGFR/LRP1/GPC1/TCAF1/SORBS1/MMP14/PTN/MIEF1/DAB2/HRAS/PRKCI/CLN3/CLTC/PPFIA1/ITGB1/ANK3/GSN/LYPLA1/SLC5A3/PDPK1 21 GO:1904951 positive regulation of establishment of protein localization 32/982 319/18722 0.00034593097049703 0.0139268963312898 GJA1/CDH1/EGFR/MYH10/WLS/LRP1/TCAF1/ISL1/SOX4/FRMD4A/TMEM30B/MIEF1/HRAS/GLI3/KCNN4/EXPH5/CLN3/TARDBP/TM9SF4/PPARD/MDM2/PINK1/TM7SF3/ANK3/IRS2/TRIM28/CD2AP/LEPROT/TCF7L2/BAD/HUWE1/CEP135 32 GO:0006486 protein glycosylation 25/982 226/18722 0.000353301250723641 0.0139268963312898 EXTL2/MGAT3/TUSC3/MOGS/GALNT18/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/DPAGT1/FUT8/GALNT11/B3GNT3/B4GAT1/TET2/STT3A/GFPT1/PMM2/RPN2/EXT2/ST3GAL6/TRIP11/DDOST 25 GO:0043413 macromolecule glycosylation 25/982 226/18722 0.000353301250723641 0.0139268963312898 EXTL2/MGAT3/TUSC3/MOGS/GALNT18/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/DPAGT1/FUT8/GALNT11/B3GNT3/B4GAT1/TET2/STT3A/GFPT1/PMM2/RPN2/EXT2/ST3GAL6/TRIP11/DDOST 25 GO:0035331 negative regulation of hippo signaling 5/982 13/18722 0.000355114496177443 0.0139268963312898 SHANK2/WWC1/DLG5/WWC3/VGLL4 5 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 5/982 13/18722 0.000355114496177443 0.0139268963312898 PLXNB1/NRP2/NRP1/SEMA3F/PLXNB2 5 GO:0035633 maintenance of blood-brain barrier 8/982 35/18722 0.000369015037170509 0.0142008130621212 LAMC1/GJA1/LSR/JAM3/TJP1/TJP2/ITGB1/F11R 8 GO:0008654 phospholipid biosynthetic process 27/982 253/18722 0.000372979219951334 0.0142008130621212 PISD/PIP5K1A/SOCS6/PGAP2/PGAP1/GPAM/TMEM150A/CDS1/DPAGT1/PIGU/SOCS7/AGPAT1/ISYNA1/SYNJ1/CDIPT/RAB38/MVK/CLN3/CHPT1/SLC44A1/PPARD/PDGFA/IDH1/PIGF/INPPL1/GPAA1/PIP5K1B 27 GO:0043087 regulation of GTPase activity 34/982 348/18722 0.0003737286525171 0.0142008130621212 PLXNB1/NET1/MET/ADRB1/FZD10/PIP5K1A/SYDE2/PROM2/SH3BP4/ITGA6/DVL3/RASA1/NF1/AMOT/EFNA5/ALS2/ELMOD2/HRAS/DOCK9/PLXNB2/EVI5/PTK2/TGM2/FERMT2/BCAR3/CCL5/TBC1D4/SNX13/MAP4K4/TBC1D12/ITGB1/VAV3/RICTOR/F11R 34 GO:0014020 primary neural tube formation 14/982 94/18722 0.000375711695278514 0.0142008130621212 LRP2/COBL/BMP7/SPINT1/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 14 GO:0061326 renal tubule development 14/982 94/18722 0.000375711695278514 0.0142008130621212 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LGR5/LAMA5/YAP1/MAGED1/GLI3/CD24/COL4A1/AHI1/MTSS1 14 GO:0097178 ruffle assembly 9/982 44/18722 0.000389974247197622 0.0146338537653439 KANK1/COBL/PIP5K1A/TACSTD2/CYFIP1/HRAS/EPS8/EPS8L2/INPPL1 9 GO:0036293 response to decreased oxygen levels 32/982 322/18722 0.000407893525846661 0.015089167594441 SLC6A4/BMP7/PLOD2/MMP14/TGFBR3/EPAS1/PTN/NF1/SLC2A1/ALAD/ADM/MIEF1/SLC29A1/ADSL/PDLIM1/CD24/HILPDA/SLC11A2/P4HB/TM9SF4/PPARD/MDM2/CYBA/PINK1/LMNA/MALAT1/DPP4/HSP90B1/PGF/BAD/CCNA2/RBPJ 32 GO:0043010 camera-type eye development 32/982 322/18722 0.000407893525846661 0.015089167594441 FBN1/FBN2/TENM3/OBSL1/LRP5/BMP7/KDM5B/NAGLU/NHS/EFEMP1/NRP1/CHD7/PTN/NF1/FAT1/ACVR2B/RDH10/TSKU/LIMK2/FLT1/SERPINF1/ATP2B1/TFAP2A/GLI3/BCAR3/COL4A1/AHI1/IMPDH2/FOXC1/CLIC4/VIM/RRM1 32 GO:0046620 regulation of organ growth 15/982 106/18722 0.000414788270544055 0.0152361663320971 GJA1/SLC6A4/FGFR2/PARP2/YAP1/WWC1/TGFBR3/DUSP9/LATS2/BASP1/WWC3/DUSP6/FOXC1/VGLL4/RBPJ 15 GO:0001649 osteoblast differentiation 25/982 229/18722 0.000431164712356203 0.0157269590185311 FBN2/LGR4/LRP5/FGFR2/BMP7/RRBP1/YAP1/PPARG/IL6ST/NF1/ACVR2B/SMOC1/DLX5/GLI3/AXIN2/RDH14/PTK2/CEBPA/CRIM1/FERMT2/ESRRA/CLTC/CDK6/DHX9/SMAD5 25 GO:0003151 outflow tract morphogenesis 12/982 74/18722 0.000438836435155059 0.015861490397855 LRP2/NRP2/FGFR2/GJA5/BMP7/ISL1/NRP1/TGFBR3/FOLR1/TBX3/FOXC1/RBPJ 12 GO:0030203 glycosaminoglycan metabolic process 16/982 118/18722 0.000440934836596814 0.015861490397855 ITIH5/CHPF/NAGLU/GCNT2/GNS/B3GNT3/DSEL/B4GAT1/GLCE/CLTC/XYLT1/FUCA1/EXT2/ST3GAL6/FOXC1/GUSB 16 GO:0007605 sensory perception of sound 19/982 154/18722 0.000457550850408072 0.0163040341840927 LRP2/ATP6V1B1/SLC52A3/PGAP1/CHD7/MYO7A/SLC1A3/WFS1/TRIOBP/TFAP2A/TPRN/USP53/ALDH7A1/NAV2/TBL1X/EPS8L2/BIRC5/SCARB2/CCDC50 19 GO:0031532 actin cytoskeleton reorganization 15/982 107/18722 0.000459488693455065 0.0163040341840927 THSD7A/PIP5K1A/NRP1/FER/NRK/CLDN19/GAB1/CTTN/HRAS/TJP1/EPS8/GSN/RICTOR/CD2AP/F11R 15 GO:0051180 vitamin transport 9/982 45/18722 0.000465068887285496 0.0163905359194672 LRP2/SLC19A3/SLC19A1/SLC52A3/ABCG2/SLC52A1/FOLR1/SLC2A1/SLC52A2 9 GO:0010464 regulation of mesenchymal cell proliferation 7/982 28/18722 0.000479313980128226 0.0167792061768378 LRP5/FGFR2/NFIB/PTN/PDGFA/LMNA/IRS2 7 GO:0048511 rhythmic process 30/982 298/18722 0.000492177068413951 0.0171146372589811 ADAMTS1/LGR4/EGFR/SLC6A4/ADRB1/BHLHE41/KDM5B/NAGLU/ZFHX3/CLDN4/PPARG/DDB1/MAGED1/PTN/GNA11/ID1/SERPINF1/TARDBP/PHLPP1/GFPT1/PSPC1/TOP2A/DHX9/METTL3/NR2F6/IMPDH2/TOP1/OPN3/ASS1/HUWE1 30 GO:0061333 renal tubule morphogenesis 12/982 75/18722 0.0004979165580411 0.0171995547466383 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LGR5/LAMA5/MAGED1/GLI3/COL4A1/AHI1/MTSS1 12 GO:0001755 neural crest cell migration 10/982 55/18722 0.000510648051211486 0.0175232910205204 SEMA6D/SEMA6A/NRP2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/SEMA4C/FOLR1 10 GO:0048864 stem cell development 13/982 86/18722 0.000519577426600529 0.0177131755369174 SEMA6D/SEMA6A/NRP2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/SEMA4C/FOLR1/RDH10/MSI2/FOXC1 13 GO:0030323 respiratory tube development 21/982 181/18722 0.000543325525180249 0.0183351210028178 DAG1/EGFR/FGFR2/LAMA5/YAP1/MME/NFIB/MMP14/EPAS1/PTN/DLG5/RDH10/TRAF4/GLI3/ESRP2/CEBPA/DPPA4/SPARC/PDGFA/NPHP3/RBPJ 21 GO:0072175 epithelial tube formation 17/982 132/18722 0.000544851180106741 0.0183351210028178 LRP2/IRX2/FGFR2/COBL/BMP7/SPINT1/SOX4/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 17 GO:0055010 ventricular cardiac muscle tissue morphogenesis 9/982 46/18722 0.000551642195206074 0.0184446518602236 LRP2/FGFR2/DSP/ISL1/TGFBR3/CHD7/PKP2/FOXC1/RBPJ 9 GO:0035330 regulation of hippo signaling 6/982 21/18722 0.000563559742688661 0.0186046051763548 SHANK2/WWC1/DLG5/WWC3/NEK8/VGLL4 6 GO:0045056 transcytosis 6/982 21/18722 0.000563559742688661 0.0186046051763548 LRP2/LRP1/IGF1R/MAL2/CLTC/RAB17 6 GO:0001837 epithelial to mesenchymal transition 19/982 157/18722 0.000582812854553803 0.0189854055640967 DAG1/FGFR2/BMP7/ISL1/GCNT2/TGFBR3/DLG5/LRP6/DAB2/EFNA1/AXIN2/S100A4/FERMT2/TBX3/TRIM28/FOXC1/TCF7L2/ZNF750/RBPJ 19 GO:0001838 embryonic epithelial tube formation 16/982 121/18722 0.00058506382873231 0.0189854055640967 LRP2/IRX2/COBL/BMP7/SPINT1/SOX4/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 16 GO:0010631 epithelial cell migration 34/982 357/18722 0.000592162507276814 0.0189854055640967 PLPP3/KANK1/NR2F2/MET/NRP2/TACSTD2/FERMT1/NRP1/PPARG/PTN/NF1/AMOT/DOCK1/ID1/TMSB4X/MARVELD3/SERPINF1/EFNA1/EPHB4/PTK2/RAB13/HDAC6/SPARC/PPARD/LGMN/MAP4K4/ITGB1/GRN/PLK2/FSTL1/DPP4/CAPN7/PDPK1/ANXA3 34 GO:0031529 ruffle organization 10/982 56/18722 0.000592879294488869 0.0189854055640967 KANK1/COBL/PIP5K1A/TACSTD2/CYFIP1/HRAS/EPS8/EPS8L2/LIMA1/INPPL1 10 GO:0061351 neural precursor cell proliferation 18/982 145/18722 0.000593293923878023 0.0189854055640967 LRP2/SLC6A4/FGFR2/SPINT1/TEAD3/PTN/NF1/ADGRG1/SPINT2/ASPM/PLXNB2/EML1/GLI3/FZD6/RACGAP1/HOOK3/RERE/RRM1 18 GO:0048638 regulation of developmental growth 32/982 330/18722 0.00062372864199259 0.0198376133941058 GJA1/SEMA6D/SEMA6A/SLC6A4/LRP1/ADRB1/APP/FGFR2/PARP2/YAP1/NRP1/WWC1/SEMA3F/TGFBR3/SEMA4C/GPAM/CHD7/CYFIP1/DUSP9/CTTN/LATS2/BASP1/WWC3/DPYSL2/PPARD/MAP3K13/LGMN/DUSP6/AFG3L2/FOXC1/VGLL4/RBPJ 32 GO:0001843 neural tube closure 13/982 88/18722 0.00065079593003815 0.0205730398247212 LRP2/COBL/SPINT1/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 13 GO:1903829 positive regulation of cellular protein localization 28/982 276/18722 0.000661687553825711 0.0207913390406922 CDH1/EGFR/LRP1/MGAT3/TCAF1/YAP1/TFRC/SORBS1/PTN/GNAI1/MIEF1/LIMK2/HRAS/PRKCI/GLI3/CLN3/TARDBP/FERMT2/TM9SF4/PINK1/ITGB1/ANK3/TRIM28/CD2AP/LEPROT/SLC5A3/PDPK1/HUWE1 28 GO:1900024 regulation of substrate adhesion-dependent cell spreading 10/982 57/18722 0.000685754927553424 0.0213208223447133 KANK1/TACSTD2/NRP1/FBLN1/EFNA5/DOCK1/TRIOBP/PTK2/FERMT2/P4HB 10 GO:0090132 epithelium migration 34/982 360/18722 0.00068671360312727 0.0213208223447133 PLPP3/KANK1/NR2F2/MET/NRP2/TACSTD2/FERMT1/NRP1/PPARG/PTN/NF1/AMOT/DOCK1/ID1/TMSB4X/MARVELD3/SERPINF1/EFNA1/EPHB4/PTK2/RAB13/HDAC6/SPARC/PPARD/LGMN/MAP4K4/ITGB1/GRN/PLK2/FSTL1/DPP4/CAPN7/PDPK1/ANXA3 34 GO:0110053 regulation of actin filament organization 28/982 277/18722 0.000700290154580199 0.0216136890313037 KANK1/MET/TACSTD2/KANK4/SCIN/NRP1/RASA1/SWAP70/SYNPO/FER/CYFIP1/PPP1R9A/ID1/CTTN/TMSB4X/TRIOBP/TJP1/NCKAP1/WASL/FERMT2/EPS8/PPFIA1/LIMA1/MTSS1/GSN/RICTOR/TRIM27/F11R 28 GO:0060840 artery development 14/982 100/18722 0.000712149644263208 0.0217444380660076 LRP2/LRP1/GJA5/ADAMTS6/SOX4/NRP1/CHD7/FOLR1/NF1/ACVR2B/LDLR/GLI3/FOXC1/RBPJ 14 GO:0007409 axonogenesis 38/982 418/18722 0.00071286405469465 0.0217444380660076 PLXNB1/DAG1/SEMA6D/SEMA6A/LRP1/APP/NRP2/FGFR2/COBL/BMP7/NOTCH3/LAMA5/ISL1/NRP1/NFIB/SEMA3F/SEMA4C/SIAH1/EFNA5/CYFIP1/CTTN/ALS2/TSKU/DLX5/EFNA1/PLXNB2/EPHB4/GLI3/PARD3/PTK2/HDAC6/DPYSL2/MAP3K13/ITGB1/AFG3L2/ANK3/ENAH/BSG 38 GO:0007369 gastrulation 21/982 185/18722 0.000725093266255675 0.0218961366680357 LAMB1/ITGB4/GJA1/DAG1/ITGAV/COL4A2/WLS/LRP5/FGFR2/BMP7/ITGB5/MMP14/KIF16B/AMOT/MMP15/NPHP3/DUSP5/ITGB1/EXT2/FOXC1/TXNRD1 21 GO:0060606 tube closure 13/982 89/18722 0.000726233060500416 0.0218961366680357 LRP2/COBL/SPINT1/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/LMO4/FZD6/NPHP3/BCL10 13 GO:0140058 neuron projection arborization 7/982 30/18722 0.000751897329962634 0.0222366894764024 LRP2/TPBG/DVL3/NRP1/PTN/PAK6/MAP3K13 7 GO:0051127 positive regulation of actin nucleation 5/982 15/18722 0.000758844081058211 0.0222366894764024 SCIN/CYFIP1/NCKAP1/WASL/GSN 5 GO:0086069 bundle of His cell to Purkinje myocyte communication 5/982 15/18722 0.000758844081058211 0.0222366894764024 GJA5/DSG2/DSP/DSC2/PKP2 5 GO:1900029 positive regulation of ruffle assembly 5/982 15/18722 0.000758844081058211 0.0222366894764024 COBL/CYFIP1/HRAS/EPS8/EPS8L2 5 GO:1905146 lysosomal protein catabolic process 5/982 15/18722 0.000758844081058211 0.0222366894764024 LRP2/LRP1/MGAT3/LDLR/CLN3 5 GO:0072073 kidney epithelium development 17/982 136/18722 0.000769151433078091 0.0222970713664131 LGR4/PBX1/IRX2/KIF26B/FGFR2/TACSTD2/BMP7/LAMA5/YAP1/MAGED1/GLI3/CD24/BASP1/AHI1/MTSS1/SMAD5/FOXC1 17 GO:0010001 glial cell differentiation 24/982 225/18722 0.000775284159586062 0.0222970713664131 ITGB4/DAG1/EGFR/LRP1/APP/GPC1/SPINT1/SOX4/NFIB/IL6ST/PTN/NF1/TNFRSF21/ERBB3/LDLR/GLI3/PARD3/CDK6/GSTP1/ADGRG6/GRN/METTL3/VIM/BACE2 24 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 21/982 186/18722 0.000778003640469169 0.0222970713664131 GJA1/WLS/TRIML2/TFRC/GPR89A/BRD4/TRIM6/TMEM101/TGM2/MAP3K7/TAB3/TMED4/S100A4/PINK1/SLC35B2/TSPAN6/TFG/PLK2/TRIM27/DDX1/BCL10 21 GO:0120032 regulation of plasma membrane bounded cell projection assembly 21/982 186/18722 0.000778003640469169 0.0222970713664131 KANK1/COBL/TACSTD2/YAP1/NRP1/FER/CYFIP1/PPP1R9A/LIMK2/HRAS/NCKAP1/WASL/FNBP1L/CLN3/EPS8/EPS8L2/BIN3/RAB17/SDCCAG8/KLF5/CEP135 21 GO:0010463 mesenchymal cell proliferation 8/982 39/18722 0.000800909050054081 0.0228280962026343 LRP5/FGFR2/BMP7/NFIB/PTN/PDGFA/LMNA/IRS2 8 GO:1905039 carboxylic acid transmembrane transport 18/982 149/18722 0.00082062545882769 0.0232629477893763 LRP2/SLC38A9/SLC19A1/SLC16A1/SLC25A13/FOLR1/SLC2A1/SLC1A3/SLC43A2/SLC13A3/SLC1A5/SLC25A1/SLC7A6/ITGB1/SLC38A2/IRS2/SLC7A2/LRRC8D 18 GO:0050714 positive regulation of protein secretion 17/982 137/18722 0.000836198766619013 0.0235762852253231 GJA1/EGFR/MYH10/WLS/LRP1/ISL1/SOX4/FRMD4A/KCNN4/EXPH5/TARDBP/PPARD/TM7SF3/IRS2/CD2AP/TCF7L2/BAD 17 GO:0051494 negative regulation of cytoskeleton organization 19/982 162/18722 0.000857575764367475 0.0239242070901851 KANK1/MET/TACSTD2/KANK4/SCIN/SWAP70/PPP1R9A/TMSB4X/TRIOBP/TJP1/HDAC6/CAMSAP2/EPS8/TRIM37/PPFIA1/LIMA1/TPX2/GSN/F11R 19 GO:0070085 glycosylation 25/982 240/18722 0.000860292009196019 0.0239242070901851 EXTL2/MGAT3/TUSC3/MOGS/GALNT18/GCNT2/B3GNT5/TMTC3/ALG6/GXYLT1/UGGT2/DPAGT1/FUT8/GALNT11/B3GNT3/B4GAT1/TET2/STT3A/GFPT1/PMM2/RPN2/EXT2/ST3GAL6/TRIP11/DDOST 25 GO:0050878 regulation of body fluid levels 35/982 379/18722 0.000862298875183053 0.0239242070901851 F5/GJA1/EGFR/MET/PRLR/LSR/GJA5/ATP6V1B1/UBASH3B/GNA12/CLDN4/FBLN1/IL6ST/LMAN1/ADM/SLC29A1/WFS1/PDSS2/KCNN4/CCND1/ANXA5/FZD6/C1QTNF1/PDGFA/CYBA/CD59/PPAT/HPS5/VAV3/EXT2/AKR1B1/CDO1/ANXA2/NME1/F11R 35 GO:0090130 tissue migration 34/982 365/18722 0.000874054048135051 0.0241220418786901 PLPP3/KANK1/NR2F2/MET/NRP2/TACSTD2/FERMT1/NRP1/PPARG/PTN/NF1/AMOT/DOCK1/ID1/TMSB4X/MARVELD3/SERPINF1/EFNA1/EPHB4/PTK2/RAB13/HDAC6/SPARC/PPARD/LGMN/MAP4K4/ITGB1/GRN/PLK2/FSTL1/DPP4/CAPN7/PDPK1/ANXA3 34 GO:0048771 tissue remodeling 20/982 175/18722 0.000881460412693872 0.0241684473041266 GJA1/LGR4/EGFR/LRP5/ELF3/SYT7/TFRC/UBASH3B/MMP14/EPAS1/CHD7/PTN/NF1/ACVR2B/P3H4/TGM2/MDM2/CST3/FOXC1/RBPJ 20 GO:1903825 organic acid transmembrane transport 18/982 150/18722 0.00088790817598102 0.0241684473041266 LRP2/SLC38A9/SLC19A1/SLC16A1/SLC25A13/FOLR1/SLC2A1/SLC1A3/SLC43A2/SLC13A3/SLC1A5/SLC25A1/SLC7A6/ITGB1/SLC38A2/IRS2/SLC7A2/LRRC8D 18 GO:0060491 regulation of cell projection assembly 21/982 188/18722 0.000893895029505559 0.0241684473041266 KANK1/COBL/TACSTD2/YAP1/NRP1/FER/CYFIP1/PPP1R9A/LIMK2/HRAS/NCKAP1/WASL/FNBP1L/CLN3/EPS8/EPS8L2/BIN3/RAB17/SDCCAG8/KLF5/CEP135 21 GO:0014033 neural crest cell differentiation 13/982 91/18722 0.000899307819371351 0.0241684473041266 SEMA6D/SEMA6A/NRP2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/SEMA4C/FOLR1/LRP6/RDH10/FOXC1 13 GO:0120193 tight junction organization 12/982 80/18722 0.000903337612681357 0.0241684473041266 SVEP1/GJA1/LSR/CLDN4/CLDN19/MARVELD3/TJP1/PARD3/RAB13/MPP7/CLDN7/F11R 12 GO:0035107 appendage morphogenesis 17/982 138/18722 0.00090817018244034 0.0241684473041266 FBN2/PBX1/FRAS1/LRP5/FGFR2/BMP7/FREM2/SOX4/DLX6/CHD7/RDH10/DLX5/TFAP2A/GLI3/FZD6/TBX3/FBXW4 17 GO:0035108 limb morphogenesis 17/982 138/18722 0.00090817018244034 0.0241684473041266 FBN2/PBX1/FRAS1/LRP5/FGFR2/BMP7/FREM2/SOX4/DLX6/CHD7/RDH10/DLX5/TFAP2A/GLI3/FZD6/TBX3/FBXW4 17 GO:1900027 regulation of ruffle assembly 7/982 31/18722 0.00092772791408423 0.0245635979688495 KANK1/COBL/TACSTD2/CYFIP1/HRAS/EPS8/EPS8L2 7 GO:0018279 protein N-linked glycosylation via asparagine 6/982 23/18722 0.000958138306168832 0.025240653560488 TUSC3/UGGT2/FUT8/STT3A/RPN2/DDOST 6 GO:0014032 neural crest cell development 12/982 81/18722 0.00101081743798184 0.0264945917412729 SEMA6D/SEMA6A/NRP2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/SEMA4C/FOLR1/RDH10/FOXC1 12 GO:0030324 lung development 20/982 177/18722 0.00101600140589034 0.0264973166656202 DAG1/EGFR/FGFR2/LAMA5/YAP1/MME/NFIB/MMP14/EPAS1/PTN/DLG5/RDH10/GLI3/ESRP2/CEBPA/DPPA4/SPARC/PDGFA/NPHP3/RBPJ 20 GO:0010720 positive regulation of cell development 29/982 298/18722 0.00103765888417919 0.0269275061685504 LRP2/PLXNB1/DAG1/EGFR/OBSL1/LRP1/ETV5/SPINT1/MME/NRP1/IL6ST/ANKRD27/CUX1/PTN/ASPM/CYFIP1/DOCK1/TRIOBP/SERPINF1/PRKCI/PLXNB2/SYNJ1/GLI3/TGM2/FERMT2/P4HB/MAP3K13/BAD/F11R 29 GO:0021783 preganglionic parasympathetic fiber development 5/982 16/18722 0.00105638888419929 0.0269947767004273 NRP2/NRP1/SEMA3F/TFAP2A/NAV2 5 GO:0033631 cell-cell adhesion mediated by integrin 5/982 16/18722 0.00105638888419929 0.0269947767004273 PLPP3/SWAP70/CCL5/ITGB1/DPP4 5 GO:0030177 positive regulation of Wnt signaling pathway 17/982 140/18722 0.00106804671666956 0.0269947767004273 LGR4/KANK1/EGFR/WLS/FGFR2/LGR5/SOX4/YAP1/WNK2/ASPM/SPIN1/DAB2/DLX5/TBL1X/USP47/ATP6V1C2/RBPJ 17 GO:0008154 actin polymerization or depolymerization 23/982 217/18722 0.00107646055530817 0.0269947767004273 KANK1/COBL/KANK4/SCIN/RASA1/SWAP70/FER/CYFIP1/MICAL3/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/EPS8/MSRB2/DIAPH3/LIMA1/ENAH/GSN/RICTOR/TRIM27 23 GO:0021782 glial cell development 15/982 116/18722 0.00108293949689749 0.0269947767004273 ITGB4/DAG1/EGFR/LRP1/APP/SOX4/NF1/LDLR/PARD3/CDK6/GSTP1/ADGRG6/GRN/VIM/BACE2 15 GO:0030326 embryonic limb morphogenesis 15/982 116/18722 0.00108293949689749 0.0269947767004273 FBN2/PBX1/FRAS1/LRP5/BMP7/FREM2/DLX6/CHD7/RDH10/DLX5/TFAP2A/GLI3/FZD6/TBX3/FBXW4 15 GO:0035113 embryonic appendage morphogenesis 15/982 116/18722 0.00108293949689749 0.0269947767004273 FBN2/PBX1/FRAS1/LRP5/BMP7/FREM2/DLX6/CHD7/RDH10/DLX5/TFAP2A/GLI3/FZD6/TBX3/FBXW4 15 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 16/982 128/18722 0.00108508470280571 0.0269947767004273 FBN1/FBN2/LTBP1/NREP/FERMT1/RASL11B/TGFBR3/PPARG/FOLR1/PEG10/LATS2/DAB2/CDKN1C/ZNF451/GLG1/PDPK1 16 GO:0048562 embryonic organ morphogenesis 28/982 285/18722 0.00108682958341444 0.0269947767004273 FBN1/FBN2/FGFR2/BMP7/NAGLU/YAP1/ATP6V1B1/EFEMP1/MMP14/DLX6/CHD7/FOLR1/MYO7A/RDH10/TRIOBP/DLX5/EFNA1/TFAP2A/TPRN/GLI3/FZD6/TBX3/NPHP3/SLC39A1/MFAP5/AHI1/SLC39A3/INSIG1 28 GO:0010039 response to iron ion 7/982 32/18722 0.00113438449420781 0.0279101392537167 ACO1/B2M/ALAD/TFAP2A/CCND1/SLC11A2/MDM2 7 GO:0072337 modified amino acid transport 7/982 32/18722 0.00113438449420781 0.0279101392537167 LRP2/GJA1/SLC19A1/SLC16A12/FOLR1/SLC13A3/SLC38A2 7 GO:1902904 negative regulation of supramolecular fiber organization 19/982 166/18722 0.00115120848089301 0.0281531623186398 KANK1/MET/TACSTD2/KANK4/SCIN/SWAP70/PPP1R9A/TMSB4X/TRIOBP/LDLR/TJP1/HDAC6/CAMSAP2/EPS8/PPFIA1/LIMA1/TPX2/GSN/F11R 19 GO:0098656 anion transmembrane transport 25/982 245/18722 0.00115505688960677 0.0281531623186398 LRP2/GJA1/SLC26A2/SLC35B4/TCAF1/GABRE/SLC38A9/SLC19A1/SLC16A1/SLC16A12/SLC25A13/SLC4A2/FOLR1/SLC1A3/SLC43A2/SLC13A3/SLC1A5/SLC25A4/SLC25A1/SLC35B2/SLC25A17/ITGB1/SLC35D1/SLC7A2/LRRC8D 25 GO:0006022 aminoglycan metabolic process 16/982 129/18722 0.00117983574441382 0.0285932246631804 ITIH5/CHPF/NAGLU/GCNT2/GNS/B3GNT3/DSEL/B4GAT1/GLCE/CLTC/XYLT1/FUCA1/EXT2/ST3GAL6/FOXC1/GUSB 16 GO:0016032 viral process 37/982 415/18722 0.00118407525445686 0.0285932246631804 DAG1/EGFR/ITGAV/ITGB5/TRIML2/MOGS/TFRC/NRP1/SLC52A1/EIF2AK4/DDB1/CTSL/CD46/FUT8/LDLR/TRIM6/SLC1A5/HACD3/TARDBP/P4HB/CCL5/RXRA/SLC52A2/ITGB1/TOP2A/DHX9/NUP153/DPP4/TRIM28/SCARB2/BSG/GSN/TRIM27/RRAGA/SRPK1/F11R/TAF11 37 GO:0042886 amide transport 29/982 301/18722 0.00121213955999411 0.0287721717167623 LRP2/GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC19A1/SLC16A1/ABCG2/CHD7/FOLR1/EFNA5/PLEKHA8/CAMK2G/FAM3B/SLC13A3/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/PSAP/IRS2/DPP4/TCF7L2/BAD/ENY2 29 GO:0010975 regulation of neuron projection development 39/982 445/18722 0.0012175249020678 0.0287721717167623 PLXNB1/TENM3/SEMA6D/KANK1/SEMA6A/OBSL1/LRP1/COBL/BMP7/ITGA6/NRP1/SEMA3F/SEMA4C/ANKRD27/CUX1/PTN/CYFIP1/PPP1R9A/B2M/CAMK2G/ID1/TSKU/SERPINF1/PRKCI/EFNA1/PLXNB2/PTPRF/CAMSAP2/MDM2/MAP3K13/MAP4K4/GRN/DENND5A/CREB3L2/SCARB2/RAB17/NME1/VIM/ITM2C 39 GO:0018196 peptidyl-asparagine modification 6/982 24/18722 0.00122138586832619 0.0287721717167623 TUSC3/UGGT2/FUT8/STT3A/RPN2/DDOST 6 GO:1902414 protein localization to cell junction 13/982 94/18722 0.0012228327827952 0.0287721717167623 DAG1/LSR/DSP/DLG5/JAM3/MARVELD3/HRAS/NSG1/TJP1/TJP2/MPP7/FERMT2/F11R 13 GO:0002934 desmosome organization 4/982 10/18722 0.0012245824618714 0.0287721717167623 DSG2/DSP/PERP/PKP2 4 GO:0061299 retina vasculature morphogenesis in camera-type eye 4/982 10/18722 0.0012245824618714 0.0287721717167623 LRP5/NRP1/COL4A1/CLIC4 4 GO:1903036 positive regulation of response to wounding 11/982 72/18722 0.00125125356493035 0.0292669892137969 PLPP3/KANK1/LRP1/FERMT1/CLDN4/PTN/HRAS/PTK2/FERMT2/ITGB1/GRN 11 GO:0090263 positive regulation of canonical Wnt signaling pathway 14/982 106/18722 0.0012744402053699 0.0296762504964705 LGR4/KANK1/EGFR/WLS/FGFR2/LGR5/SOX4/YAP1/WNK2/ASPM/DLX5/TBL1X/USP47/RBPJ 14 GO:0022612 gland morphogenesis 15/982 118/18722 0.00129145444779554 0.0299387839986735 DAG1/LRP5/FGFR2/BMP7/KDM5B/LAMA5/ELF3/NRP1/NFIB/PTN/GLI3/ESRP2/TGM2/TBX3/PDGFA 15 GO:0019058 viral life cycle 30/982 317/18722 0.0013364673191256 0.0307042854525504 DAG1/EGFR/ITGAV/ITGB5/TRIML2/TFRC/NRP1/SLC52A1/EIF2AK4/DDB1/CTSL/CD46/LDLR/TRIM6/SLC1A5/HACD3/P4HB/CCL5/SLC52A2/ITGB1/TOP2A/NUP153/DPP4/TRIM28/SCARB2/BSG/GSN/TRIM27/SRPK1/F11R 30 GO:0060560 developmental growth involved in morphogenesis 24/982 234/18722 0.00133816228604611 0.0307042854525504 SEMA6D/SEMA6A/LRP1/APP/NRP2/KIF26B/FGFR2/COBL/KDM5B/YAP1/NRP1/SEMA3F/EIF2AK4/SEMA4C/CYFIP1/RDH10/PAK6/CTTN/HDAC6/DPYSL2/MAP3K13/ITGB1/BIN3/TRIM28 24 GO:0007162 negative regulation of cell adhesion 29/982 303/18722 0.00134213517699032 0.0307042854525504 PLXNB1/CDH1/KANK1/SEMA6A/LRP1/TACSTD2/SOCS6/PAWR/UBASH3B/RASA1/SWAP70/MMP14/GCNT2/FBLN1/DLG5/EFNA5/SPINT2/JAM3/TNFRSF21/ERBB3/PLXNB2/DACT2/GLI3/PTK2/C1QTNF1/YTHDF2/MAP4K4/METTL3/ASS1 29 GO:0010810 regulation of cell-substrate adhesion 23/982 221/18722 0.00137514520526962 0.0310981035095324 CCDC80/DAG1/KANK1/LRP1/TACSTD2/ITGA6/FERMT1/NRP1/RASA1/MMP14/GCNT2/FBLN1/PTN/NF1/EFNA5/DOCK1/TRIOBP/PTK2/FERMT2/P4HB/CDK6/MAP4K4/HSD17B12 23 GO:0003382 epithelial cell morphogenesis 7/982 33/18722 0.00137546257409514 0.0310981035095324 MET/FAT1/SPINT2/DACT2/FLNB/RILPL1/CLIC4 7 GO:0022407 regulation of cell-cell adhesion 39/982 448/18722 0.00137723579576342 0.0310981035095324 TENM3/PLPP3/CDH1/KIF26B/BMP7/SOCS6/SOX4/TFRC/PAWR/UBASH3B/SWAP70/GCNT2/IL6ST/GPAM/DLG5/EFNA5/SPINT2/B2M/TNFRSF21/CD46/HLA-A/TJP1/NFAT5/GLI3/YES1/PTK2/CD24/HLA-E/C1QTNF1/YTHDF2/CCL5/ANK3/METTL3/DPP4/FLOT2/BAD/F11R/ASS1/BCL10 39 GO:0031103 axon regeneration 9/982 52/18722 0.0013902866504179 0.0311262982340651 DAG1/LRP1/ISL1/NREP/FOLR1/PTN/JAM3/PTPRF/GRN 9 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 16/982 131/18722 0.00139041938047108 0.0311262982340651 FBN1/FBN2/LTBP1/NREP/FERMT1/RASL11B/TGFBR3/PPARG/FOLR1/PEG10/LATS2/DAB2/CDKN1C/ZNF451/GLG1/PDPK1 16 GO:0007548 sex differentiation 27/982 276/18722 0.00140730386117366 0.0313696450422298 LRP2/ADAMTS1/LGR4/NR2F2/PBX1/CTSV/MMP14/CHD7/ADGRG1/ASPM/RDH10/TFAP2C/RHOBTB3/SPATA2/DHCR24/CCND1/RAB13/BASP1/TBX3/IDH1/NUPR1/PRDX4/BRCA2/WDR48/SMAD5/FOXC1/RRM1 27 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 5/982 17/18722 0.00143239457327503 0.0316583478567905 B2M/HLA-B/HLA-A/HLA-C/HLA-E 5 GO:0061298 retina vasculature development in camera-type eye 5/982 17/18722 0.00143239457327503 0.0316583478567905 LRP5/NRP1/ACVR2B/COL4A1/CLIC4 5 GO:0070482 response to oxygen levels 32/982 347/18722 0.00143880553962563 0.0316658636906637 SLC6A4/BMP7/PLOD2/MMP14/TGFBR3/EPAS1/PTN/NF1/SLC2A1/ALAD/ADM/MIEF1/SLC29A1/ADSL/PDLIM1/CD24/HILPDA/SLC11A2/P4HB/TM9SF4/PPARD/MDM2/CYBA/PINK1/LMNA/MALAT1/DPP4/HSP90B1/PGF/BAD/CCNA2/RBPJ 32 GO:0042176 regulation of protein catabolic process 35/982 391/18722 0.00148130086807206 0.0324641400330415 LRP2/GJA1/CDH1/EGFR/LRP1/MGAT3/GNA12/DDB1/TMTC3/ALAD/DAB2/LDLR/EFNA1/TIMP3/RNF128/PTK2/CEBPA/PSMD1/SH3D19/MDM2/MAGEF1/PINK1/NUPR1/CST3/PLK2/PSME3/PTTG1IP/FBXO22/RAD23B/USP14/ANXA2/VGLL4/USP25/AZIN1/HUWE1 35 GO:0010769 regulation of cell morphogenesis involved in differentiation 13/982 96/18722 0.0014882862539672 0.0324807577434849 KANK1/OBSL1/TACSTD2/NRP1/FBLN1/ANKRD27/CUX1/EFNA5/DOCK1/TRIOBP/PTK2/FERMT2/P4HB 13 GO:0048143 astrocyte activation 6/982 25/18722 0.00153655202490153 0.0332558313771219 EGFR/LRP1/APP/LDLR/GRN/BACE2 6 GO:0090382 phagosome maturation 6/982 25/18722 0.00153655202490153 0.0332558313771219 SYT7/MYO7A/MREG/RAB38/CLN3/RAB31 6 GO:0061383 trabecula morphogenesis 8/982 43/18722 0.00156820452422317 0.0333626141583853 FBN2/ADAMTS1/PLXNB1/BMP7/TGFBR3/CHD7/ADGRG6/RBPJ 8 GO:0007040 lysosome organization 11/982 74/18722 0.00157346684872753 0.0333626141583853 HOOK2/NAGLU/SYT7/GAA/MYO7A/HOOK1/TFEB/CLN3/HOOK3/GRN/SCARB2 11 GO:0048844 artery morphogenesis 11/982 74/18722 0.00157346684872753 0.0333626141583853 LRP2/LRP1/GJA5/SOX4/NRP1/CHD7/FOLR1/NF1/LDLR/FOXC1/RBPJ 11 GO:0080171 lytic vacuole organization 11/982 74/18722 0.00157346684872753 0.0333626141583853 HOOK2/NAGLU/SYT7/GAA/MYO7A/HOOK1/TFEB/CLN3/HOOK3/GRN/SCARB2 11 GO:0120192 tight junction assembly 11/982 74/18722 0.00157346684872753 0.0333626141583853 GJA1/LSR/CLDN4/CLDN19/MARVELD3/TJP1/PARD3/RAB13/MPP7/CLDN7/F11R 11 GO:0072009 nephron epithelium development 14/982 109/18722 0.00167218146370292 0.0353121397355241 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LAMA5/YAP1/MAGED1/GLI3/CD24/BASP1/AHI1/MTSS1/FOXC1 14 GO:0046474 glycerophospholipid biosynthetic process 22/982 211/18722 0.00168813673268491 0.0355053274100181 PISD/PIP5K1A/SOCS6/PGAP2/PGAP1/GPAM/TMEM150A/CDS1/PIGU/SOCS7/AGPAT1/SYNJ1/CDIPT/RAB38/CLN3/CHPT1/SLC44A1/PDGFA/PIGF/INPPL1/GPAA1/PIP5K1B 22 GO:0014031 mesenchymal cell development 12/982 86/18722 0.00172024471537815 0.036035327049849 SEMA6D/SEMA6A/NRP2/BMP7/LAMA5/ISL1/NRP1/SEMA3F/SEMA4C/FOLR1/RDH10/FOXC1 12 GO:0050769 positive regulation of neurogenesis 23/982 225/18722 0.00174230853917639 0.0363515253613761 LRP2/PLXNB1/DAG1/EGFR/OBSL1/LRP1/ETV5/SPINT1/MME/NRP1/IL6ST/ANKRD27/CUX1/PTN/ASPM/CYFIP1/SERPINF1/PRKCI/PLXNB2/SYNJ1/GLI3/TGM2/MAP3K13 23 GO:0046879 hormone secretion 28/982 295/18722 0.00182051575385981 0.0377304478102416 GJA1/EGFR/LRP1/LRP5/KDM5B/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TRPV6/ADM/CAMK2G/FAM3B/SNX4/TARDBP/PPARD/C1QTNF1/TBX3/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 28 GO:0014812 muscle cell migration 14/982 110/18722 0.00182575199681797 0.0377304478102416 ADAMTS1/SEMA6D/NET1/LRP1/NRP1/GNA12/FOXO4/P2RY6/PPARD/MDM2/CCL5/PDGFA/GSTP1/BIN3 14 GO:0060350 endochondral bone morphogenesis 9/982 54/18722 0.00183010032515167 0.0377304478102416 SERPINH1/MMP14/TSKU/DLX5/AXIN2/EXT2/INPPL1/FOXC1/TRIP11 9 GO:0003139 secondary heart field specification 4/982 11/18722 0.00184478433832778 0.0377348827792851 LRP2/ISL1/AXIN2/RBPJ 4 GO:0035581 sequestering of extracellular ligand from receptor 4/982 11/18722 0.00184478433832778 0.0377348827792851 FBN1/FBN2/LTBP1/CD46 4 GO:0048486 parasympathetic nervous system development 5/982 18/18722 0.0018984118477631 0.0386134572401177 NRP2/NRP1/SEMA3F/TFAP2A/NAV2 5 GO:0001101 response to acid chemical 16/982 135/18722 0.00190738831761548 0.0386134572401177 SLC38A9/SH3BP4/PTN/ALAD/GSS/CYBA/COL4A1/GSTP1/GCLM/AKR1B1/DNMT1/CDO1/KRT8/BAD/RRAGA/ASS1 16 GO:0060669 embryonic placenta morphogenesis 6/982 26/18722 0.00190994477913159 0.0386134572401177 FGFR2/BMP7/SPINT1/SPINT2/ADM/TRIM28 6 GO:0050708 regulation of protein secretion 26/982 268/18722 0.00192020190981821 0.0386709388479219 GJA1/EGFR/MYH10/WLS/LRP1/CD200/LRP5/ISL1/SYT7/SOX4/FRMD4A/SLC16A1/EFNA5/KCNN4/EXPH5/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/CD2AP/TCF7L2/BAD/ENY2 26 GO:0071692 protein localization to extracellular region 33/982 368/18722 0.00193551663234622 0.0388294413627612 FBN1/FBN2/GJA1/EGFR/MYH10/WLS/LRP1/CD200/LRP5/ISL1/LTBP1/SYT7/SOX4/FRMD4A/SLC16A1/EFNA5/CAMK2G/FAM3B/TVP23C/KCNN4/EXPH5/RAB13/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/CD2AP/TCF7L2/BAD/ENY2 33 GO:0031100 animal organ regeneration 11/982 76/18722 0.00196052016942242 0.0390276470343248 EGFR/TGFBR3/ADM/GLI3/CCND1/GSTP1/PPAT/PGF/CCNA2/ANXA3/ATIC 11 GO:0003231 cardiac ventricle development 15/982 123/18722 0.00196451436201766 0.0390276470343248 LRP2/FGFR2/GJA5/DSP/ISL1/SOX4/TGFBR3/CHD7/LMO4/TBX3/MDM2/PKP2/FOXC1/TRIP11/RBPJ 15 GO:0044272 sulfur compound biosynthetic process 17/982 148/18722 0.0019678433991617 0.0390276470343248 SLC26A2/CHPF/ACSS1/B3GNT3/DSEL/GSS/B4GAT1/GLCE/SLC25A1/XYLT1/SLC35B2/GSTP1/EXT2/GCLM/HSD17B12/ST3GAL6/CDO1 17 GO:0007584 response to nutrient 19/982 174/18722 0.0020011987726312 0.0394811882846841 EGFR/SLC6A4/BMP7/SLC16A1/PPARG/FOLR1/PTN/ALAD/AGL/ATP2B1/ADSL/CCND1/SPARC/PPARD/MDM2/TRIM24/GSTP1/GCLM/ASS1 19 GO:0043547 positive regulation of GTPase activity 25/982 255/18722 0.00201341949457937 0.0394811882846841 PLXNB1/NET1/ADRB1/FZD10/PIP5K1A/SYDE2/ITGA6/DVL3/RASA1/NF1/ALS2/ELMOD2/HRAS/DOCK9/EVI5/TGM2/FERMT2/BCAR3/CCL5/TBC1D4/SNX13/MAP4K4/TBC1D12/ITGB1/F11R 25 GO:1903362 regulation of cellular protein catabolic process 25/982 255/18722 0.00201341949457937 0.0394811882846841 LRP2/LRP1/MGAT3/GNA12/TMTC3/ALAD/DAB2/LDLR/EFNA1/RNF128/PTK2/CEBPA/MDM2/MAGEF1/PINK1/NUPR1/PLK2/PSME3/PTTG1IP/FBXO22/RAD23B/USP14/ANXA2/VGLL4/USP25 25 GO:0007272 ensheathment of neurons 16/982 136/18722 0.00205915323555379 0.0400766540173454 ITGB4/DAG1/GPC1/PTN/NF1/JAM3/CYFIP1/TNFRSF21/MARVELD1/DEGS1/MAL2/PARD3/PPARD/ADGRG6/EPB41L3/AFG3L2 16 GO:0008366 axon ensheathment 16/982 136/18722 0.00205915323555379 0.0400766540173454 ITGB4/DAG1/GPC1/PTN/NF1/JAM3/CYFIP1/TNFRSF21/MARVELD1/DEGS1/MAL2/PARD3/PPARD/ADGRG6/EPB41L3/AFG3L2 16 GO:0009411 response to UV 17/982 149/18722 0.00211559116420472 0.0410220204925346 EGFR/SCARA3/MME/PTPRK/EIF2AK4/DDB1/PTN/CCND1/FEN1/MDM2/UBE4B/TRIAP1/ATR/BRCA2/METTL3/USP47/OPN3 17 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 25/982 256/18722 0.00212347275365565 0.0410223477150662 LRP2/FBN1/FBN2/LRP1/BMP7/LTBP1/NREP/FERMT1/RASL11B/TGFBR3/PPARG/FOLR1/ACVR2B/PEG10/LATS2/RBPMS/DAB2/CDKN1C/DACT2/CRIM1/ZNF451/FSTL1/GLG1/PDPK1/RBPJ 25 GO:0050954 sensory perception of mechanical stimulus 19/982 175/18722 0.00213757716262357 0.0411424445765481 LRP2/ATP6V1B1/SLC52A3/PGAP1/CHD7/MYO7A/SLC1A3/WFS1/TRIOBP/TFAP2A/TPRN/USP53/ALDH7A1/NAV2/TBL1X/EPS8L2/BIRC5/SCARB2/CCDC50 19 GO:0016358 dendrite development 24/982 243/18722 0.00222193491616996 0.0426088695689063 OBSL1/APP/COBL/BMP7/TPBG/NRP1/ANKRD27/CUX1/PTN/DLG5/CYFIP1/PPP1R9A/ID1/BTBD3/EFNA1/WASL/SLC11A2/HDAC6/CAMSAP2/UBA6/ITGB1/PLK2/RAB17/RERE 24 GO:0006979 response to oxidative stress 38/982 446/18722 0.00229916192178737 0.0438832008746289 NET1/EGFR/MET/APP/MGAT3/BMP7/ETV5/SCARA3/PAWR/PTPRK/MMP14/EPAS1/FER/ALAD/RBPMS/ALS2/FUT8/GSS/PDLIM1/PAGE4/DHCR24/NFE2L1/HDAC6/P4HB/GPX8/MDM2/MSRB2/PINK1/IDH1/PRDX1/PSMB5/PPP2CB/PRDX4/GSTP1/GCLM/PRDX5/TXNRD2/BAD 38 GO:1904375 regulation of protein localization to cell periphery 15/982 125/18722 0.00230521415637429 0.0438832008746289 DAG1/EGFR/LRP1/SORBS1/MMP14/GNAI1/DAB2/HRAS/PRKCI/CLN3/CLTC/PPFIA1/ITGB1/LYPLA1/PDPK1 15 GO:0014910 regulation of smooth muscle cell migration 12/982 89/18722 0.00231405487133458 0.0438913098504769 ADAMTS1/SEMA6D/LRP1/NRP1/GNA12/FOXO4/P2RY6/PPARD/MDM2/CCL5/PDGFA/GSTP1 12 GO:0018126 protein hydroxylation 6/982 27/18722 0.00234810702857855 0.04437581978647 PLOD2/ASPH/P3H4/VIPAS39/P4HB/PRDX4 6 GO:0051962 positive regulation of nervous system development 26/982 272/18722 0.002359032650714 0.0444213512856469 LRP2/PLXNB1/DAG1/EGFR/OBSL1/LRP1/VSTM5/TPBG/ETV5/SPINT1/MME/NRP1/IL6ST/ANKRD27/CUX1/PTN/DLG5/ASPM/CYFIP1/SERPINF1/PRKCI/PLXNB2/SYNJ1/GLI3/TGM2/MAP3K13 26 GO:0043297 apical junction assembly 11/982 78/18722 0.0024216591982727 0.0452961781378562 GJA1/CLDN4/DLG5/CLDN19/MARVELD3/TJP1/PARD3/RAB13/MPP7/CLDN7/F11R 11 GO:0009880 embryonic pattern specification 10/982 67/18722 0.00245580371119461 0.0452961781378562 NRP2/FGFR2/COBL/BMP7/NRP1/SEMA3F/PGAP1/BASP1/TBX3/SMAD5 10 GO:0001974 blood vessel remodeling 8/982 46/18722 0.00245642805993717 0.0452961781378562 EPAS1/CHD7/ACVR2B/TGM2/MDM2/CST3/FOXC1/RBPJ 8 GO:0050919 negative chemotaxis 8/982 46/18722 0.00245642805993717 0.0452961781378562 SEMA6D/SEMA6A/ITGAV/NRP2/SEMA3F/SEMA4C/PDGFA/DPP4 8 GO:0002483 antigen processing and presentation of endogenous peptide antigen 5/982 19/18722 0.00246627963787407 0.0452961781378562 B2M/HLA-B/HLA-A/HLA-C/HLA-E 5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 5/982 19/18722 0.00246627963787407 0.0452961781378562 SOX4/MDM2/TRIAP1/PLK2/GTSE1 5 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 5/982 19/18722 0.00246627963787407 0.0452961781378562 ADSL/PPAT/IMPDH2/ADK/ATIC 5 GO:0046942 carboxylic acid transport 26/982 273/18722 0.00248122239717726 0.0454107228900933 LRP2/GJA1/SLC26A2/SLC38A9/SLC19A1/SLC16A1/ABCG2/SLC16A12/SLC25A13/FOLR1/SLC1A3/SLC43A2/SLC13A3/PTGES/PLA2G12A/SLC1A5/CLN3/SLC25A1/SLC7A6/SLC16A4/ITGB1/PSAP/SLC38A2/SLC35D1/SLC7A2/LRRC8D 26 GO:0034109 homotypic cell-cell adhesion 12/982 90/18722 0.00254561836410187 0.0464263824725711 PLPP3/DSG2/DSP/DSC2/UBASH3B/IL6ST/TJP2/C1QTNF1/CCL5/PKP2/ANK3/F11R 12 GO:0046661 male sex differentiation 18/982 165/18722 0.00261943668802477 0.0473903668240274 LRP2/LGR4/CTSV/MMP14/ADGRG1/ASPM/TFAP2C/RHOBTB3/SPATA2/DHCR24/CCND1/RAB13/TBX3/NUPR1/PRDX4/WDR48/SMAD5/RRM1 18 GO:0050796 regulation of insulin secretion 18/982 165/18722 0.00261943668802477 0.0473903668240274 GJA1/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/EFNA5/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 18 GO:0021559 trigeminal nerve development 4/982 12/18722 0.00265298832680522 0.0473903668240274 ISL1/NRP1/SEMA3F/TFAP2A 4 GO:0098911 regulation of ventricular cardiac muscle cell action potential 4/982 12/18722 0.00265298832680522 0.0473903668240274 DSG2/DSP/DSC2/PKP2 4 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 4/982 12/18722 0.00265298832680522 0.0473903668240274 MET/PAWR/HDAC6/PINK1 4 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 4/982 12/18722 0.00265298832680522 0.0473903668240274 PLXNB1/NRP1/SEMA3F/PLXNB2 4 GO:0015849 organic acid transport 28/982 303/18722 0.00268224483595345 0.0477494507315125 LRP2/GJA1/SLC26A2/SLC27A2/SLC38A9/SLC19A1/SLC16A1/ABCG2/PPARG/SLC25A13/FOLR1/SLC2A1/SLC1A3/SLC43A2/SLC13A3/PTGES/PLA2G12A/SLC1A5/CLN3/SLC25A1/SLC7A6/PPARD/SLC25A17/ITGB1/SLC38A2/IRS2/SLC7A2/LRRC8D 28 GO:0006862 nucleotide transport 7/982 37/18722 0.00276207780108216 0.0490033939130766 GJA1/SLC19A1/SLC25A36/SLC29A1/SLC25A4/SLC35B2/SLC25A17 7 GO:0001657 ureteric bud development 12/982 91/18722 0.00279569085190903 0.0492646063633699 LGR4/PBX1/KIF26B/FGFR2/TACSTD2/BMP7/LAMA5/MAGED1/GLI3/BASP1/SMAD5/FOXC1 12 GO:0072080 nephron tubule development 12/982 91/18722 0.00279569085190903 0.0492646063633699 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LAMA5/YAP1/MAGED1/GLI3/CD24/AHI1/MTSS1 12 GO:0014911 positive regulation of smooth muscle cell migration 8/982 47/18722 0.00282677606590638 0.0496446597971975 ADAMTS1/SEMA6D/LRP1/NRP1/FOXO4/P2RY6/MDM2/CCL5 8 GO:0071375 cellular response to peptide hormone stimulus 27/982 290/18722 0.00285120949748077 0.0496872310587497 FBN1/KANK1/SORBS1/PPARG/FER/CYFIP1/GAB1/IGF1R/PRKCI/ATP2B1/FOXO4/PTK2/RAB13/ESRRA/BCAR3/MDM2/CYBA/TBC1D4/RAB31/GSTP1/PPAT/INSIG1/IRS2/LEPROT/PDPK1/CCNA2/ASS1 27 GO:0006829 zinc ion transport 6/982 28/18722 0.0028577778599741 0.0496872310587497 SLC39A9/SLC39A11/SLC39A10/SLC39A1/SLC39A3/SLC39A7 6 GO:0051503 adenine nucleotide transport 6/982 28/18722 0.0028577778599741 0.0496872310587497 GJA1/SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17 6 GO:0007565 female pregnancy 20/982 193/18722 0.002875399813897 0.0498275263431454 ITGB4/GJA1/NR2F2/PRLR/CTSV/SLC19A1/CLDN4/FBLN1/TEAD3/PTN/SLC2A1/ADM/COMT/PPARD/SLC38A2/PPAT/TRIM28/BSG/AKR1B1/PGF 20 GO:1901264 carbohydrate derivative transport 11/982 80/18722 0.00296681743065423 0.051241456020836 GJA1/SLC35B4/SLC19A1/PLEKHA8/SLC29A1/SLC25A4/CLN3/SLC35B2/SLC25A17/PSAP/SLC35D1 11 GO:1903034 regulation of response to wounding 18/982 167/18722 0.00298661164387167 0.0514130902126556 GJA1/PLPP3/KANK1/LRP1/FERMT1/UBASH3B/CLDN4/PTN/CLDN19/HRAS/PTPRF/PTK2/FERMT2/C1QTNF1/PDGFA/ITGB1/GRN/ANXA2 18 GO:0043200 response to amino acid 14/982 116/18722 0.00301269790604801 0.0516915535458764 SLC38A9/SH3BP4/PTN/ALAD/GSS/CYBA/COL4A1/GSTP1/GCLM/DNMT1/CDO1/BAD/RRAGA/ASS1 14 GO:0007405 neuroblast proliferation 9/982 58/18722 0.00304041720167748 0.0517437054829094 FGFR2/TEAD3/PTN/NF1/ASPM/PLXNB2/EML1/GLI3/RACGAP1 9 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 24/982 249/18722 0.0030539419232802 0.0517437054829094 GJA1/WLS/TRIML2/TFRC/GPR89A/BRD4/TRAF4/TRIM6/TMEM101/TGM2/MAP3K7/TAB3/TMED4/S100A4/PINK1/SLC35B2/TSPAN6/TFG/GSTP1/PLK2/TRIM27/PDPK1/DDX1/BCL10 24 GO:0045669 positive regulation of osteoblast differentiation 10/982 69/18722 0.00306474970326833 0.0517437054829094 FBN2/LRP5/BMP7/YAP1/IL6ST/ACVR2B/GLI3/CEBPA/FERMT2/SMAD5 10 GO:0072163 mesonephric epithelium development 12/982 92/18722 0.00306533838079352 0.0517437054829094 LGR4/PBX1/KIF26B/FGFR2/TACSTD2/BMP7/LAMA5/MAGED1/GLI3/BASP1/SMAD5/FOXC1 12 GO:0072164 mesonephric tubule development 12/982 92/18722 0.00306533838079352 0.0517437054829094 LGR4/PBX1/KIF26B/FGFR2/TACSTD2/BMP7/LAMA5/MAGED1/GLI3/BASP1/SMAD5/FOXC1 12 GO:0009914 hormone transport 28/982 306/18722 0.00308485909516149 0.051905242065685 GJA1/EGFR/LRP1/LRP5/KDM5B/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TRPV6/ADM/CAMK2G/FAM3B/SNX4/TARDBP/PPARD/C1QTNF1/TBX3/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 28 GO:0097320 plasma membrane tubulation 5/982 20/18722 0.00314800436831887 0.0526281755934334 WASL/FNBP1L/MICALL1/PACSIN2/BIN3 5 GO:1901679 nucleotide transmembrane transport 5/982 20/18722 0.00314800436831887 0.0526281755934334 SLC19A1/SLC25A36/SLC25A4/SLC35B2/SLC25A17 5 GO:0072006 nephron development 16/982 142/18722 0.00319652929668456 0.0532686799089669 ENPEP/LGR4/PBX1/IRX2/KIF26B/TACSTD2/BMP7/LAMA5/YAP1/MAGED1/GLI3/CD24/BASP1/AHI1/MTSS1/FOXC1 16 GO:0030073 insulin secretion 20/982 195/18722 0.00323855369595261 0.0536376867540492 GJA1/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/EFNA5/CAMK2G/FAM3B/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 20 GO:0033628 regulation of cell adhesion mediated by integrin 8/982 48/18722 0.00323923913487835 0.0536376867540492 FERMT1/SWAP70/JAM3/EFNA1/PTK2/IFT74/CCL5/DPP4 8 GO:0033273 response to vitamin 12/982 93/18722 0.0033556584759071 0.055373849250494 EGFR/BMP7/FOLR1/PTN/ALAD/ATP2B1/CCND1/SPARC/PPARD/MDM2/TRIM24/GSTP1 12 GO:0007265 Ras protein signal transduction 30/982 337/18722 0.00337260889703119 0.055373849250494 KANK1/NET1/MET/NRP1/GNA12/RASA1/NF1/ADGRG1/CYFIP1/MRAS/CTNNAL1/ALS2/HRAS/ARHGEF11/NCKAP1/HACD3/DHCR24/EPS8/EPS8L2/MAP4K4/CYTH3/ITGB1/PPP2CB/PLK2/ARHGAP5/TRIM28/STAMBP/DNMT1/F11R/CCNA2 30 GO:0042476 odontogenesis 15/982 130/18722 0.00337593636151401 0.055373849250494 LAMB1/FGFR2/BMP7/CSF3R/LAMA5/DLX3/SLC4A2/ADM/PERP/SP6/TFAP2A/GLI3/AXIN2/BSG/FOXC1 15 GO:0021543 pallium development 18/982 169/18722 0.00339566172945116 0.0554739707278457 LAMB1/LRP1/TACC2/NF1/ADGRG1/SLC2A1/ASPM/BTBD3/TSKU/GNG12/GLI3/CDK6/UBA6/SLC38A2/BAD/NME1/ANXA3/ATIC 18 GO:0070830 bicellular tight junction assembly 10/982 70/18722 0.00341131755768909 0.0554739707278457 GJA1/CLDN4/CLDN19/MARVELD3/TJP1/PARD3/RAB13/MPP7/CLDN7/F11R 10 GO:0006767 water-soluble vitamin metabolic process 9/982 59/18722 0.00342432333841403 0.0554739707278457 SLC19A3/SLC19A1/SLC52A3/PSAT1/SLC52A1/FOLR1/SLC2A1/SLC52A2/AASDHPPT 9 GO:0090276 regulation of peptide hormone secretion 20/982 196/18722 0.00343403054404023 0.0554739707278457 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 20 GO:0015868 purine ribonucleotide transport 6/982 29/18722 0.00344585247619287 0.0554739707278457 GJA1/SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17 6 GO:0060441 epithelial tube branching involved in lung morphogenesis 6/982 29/18722 0.00344585247619287 0.0554739707278457 DAG1/FGFR2/YAP1/DLG5/RDH10/ESRP2 6 GO:1902903 regulation of supramolecular fiber organization 33/982 382/18722 0.00348795441363115 0.0559789852969232 KANK1/MET/APP/TACSTD2/KANK4/SCIN/NRP1/RASA1/SWAP70/SYNPO/FER/CYFIP1/PPP1R9A/ID1/CTTN/TMSB4X/TRIOBP/LDLR/TJP1/NCKAP1/WASL/HDAC6/CAMSAP2/FERMT2/EPS8/PPFIA1/LIMA1/MTSS1/TPX2/GSN/RICTOR/TRIM27/F11R 33 GO:0045017 glycerolipid biosynthetic process 24/982 252/18722 0.00356005117623183 0.0565582682786642 PISD/PIP5K1A/SOCS6/PGAP2/PGAP1/GPAM/TMEM150A/CDS1/PIGU/SOCS7/AGPAT1/LDLR/SYNJ1/CDIPT/RAB38/CLN3/CHPT1/SLC44A1/PDGFA/PNPLA2/PIGF/INPPL1/GPAA1/PIP5K1B 24 GO:0008544 epidermis development 29/982 324/18722 0.00361446754668734 0.0565582682786642 SVEP1/LGR4/EGFR/MCOLN3/FGFR2/PIP5K1A/LGR5/LAMA5/DSP/YAP1/FERMT1/MYO7A/ESRP1/TRIOBP/TPRN/EXPH5/MAFG/NCOA3/FZD6/PPARD/IFT74/PDGFA/FLNB/FLOT2/FOXC1/OPN3/CLIC4/ZNF750/RBPJ 29 GO:0030178 negative regulation of Wnt signaling pathway 18/982 170/18722 0.00361699288417879 0.0565582682786642 LRP1/RNF43/TPBG/ISL1/FERMT1/RBMS3/NOTUM/ZNRF3/LATS2/TSKU/DAB2/GLI3/AXIN2/FZD6/NPHP3/CBY1/TCF7L2/VGLL4 18 GO:0006644 phospholipid metabolic process 33/982 383/18722 0.00363107322857758 0.0565582682786642 PLPP3/PISD/PIP5K1A/OSBPL10/SOCS6/PGAP2/PGAP1/ABHD12/GPAM/TMEM150A/CDS1/DPAGT1/PIGU/SOCS7/AGPAT1/ISYNA1/LDLR/SYNJ1/PLA2G12A/CDIPT/RAB38/MVK/CLN3/CHPT1/SLC44A1/PPARD/PDGFA/IDH1/PIGF/SERINC2/INPPL1/GPAA1/PIP5K1B 33 GO:0006766 vitamin metabolic process 13/982 106/18722 0.00363133094564412 0.0565582682786642 LRP2/SLC19A3/SLC19A1/SLC52A3/PSAT1/SLC52A1/FOLR1/SLC2A1/RDH10/PPARD/LGMN/SLC52A2/AASDHPPT 13 GO:1905477 positive regulation of protein localization to membrane 13/982 106/18722 0.00363133094564412 0.0565582682786642 EGFR/LRP1/TCAF1/SORBS1/PTN/MIEF1/HRAS/PRKCI/CLN3/ITGB1/ANK3/SLC5A3/PDPK1 13 GO:0006661 phosphatidylinositol biosynthetic process 15/982 131/18722 0.0036326842469937 0.0565582682786642 PIP5K1A/SOCS6/PGAP2/PGAP1/TMEM150A/CDS1/PIGU/SOCS7/SYNJ1/CDIPT/PDGFA/PIGF/INPPL1/GPAA1/PIP5K1B 15 GO:0007249 I-kappaB kinase/NF-kappaB signaling 26/982 281/18722 0.00366729692251187 0.0565582682786642 GJA1/WLS/TRIML2/TFRC/GPR89A/BRD4/TRAF4/TRIM6/HACD3/TMEM101/TGM2/MAP3K7/TAB3/TMED4/S100A4/PINK1/SLC35B2/TSPAN6/TFG/PRDX4/GSTP1/PLK2/TRIM27/PDPK1/DDX1/BCL10 26 GO:0034112 positive regulation of homotypic cell-cell adhesion 4/982 13/18722 0.00367426558486201 0.0565582682786642 IL6ST/CCL5/ANK3/F11R 4 GO:0060670 branching involved in labyrinthine layer morphogenesis 4/982 13/18722 0.00367426558486201 0.0565582682786642 FGFR2/SPINT1/SPINT2/ADM 4 GO:0098814 spontaneous synaptic transmission 4/982 13/18722 0.00367426558486201 0.0565582682786642 APP/PPP1R9A/NSG1/ITGB1 4 GO:1900115 extracellular regulation of signal transduction 4/982 13/18722 0.00367426558486201 0.0565582682786642 FBN1/FBN2/LTBP1/CD46 4 GO:1900116 extracellular negative regulation of signal transduction 4/982 13/18722 0.00367426558486201 0.0565582682786642 FBN1/FBN2/LTBP1/CD46 4 GO:0048545 response to steroid hormone 30/982 339/18722 0.00367585370906196 0.0565582682786642 ESRRG/EGFR/SKP2/CTSV/BMP7/ISL1/YAP1/CLDN4/PTN/ALAD/ADM/AGL/DAB2/SERPINF1/ATP2B1/CCND1/HDAC6/SPARC/ESRRA/PPARD/MDM2/CYBA/IDH1/UBA5/RXRA/GSTP1/CDO1/BAD/ASS1/ANXA3 30 GO:0034332 adherens junction organization 8/982 49/18722 0.00369693644638568 0.0567153544245521 CDH1/DSP/DLG5/JAM3/TJP1/FERMT2/KIFC3/MTSS1 8 GO:0034284 response to monosaccharide 22/982 225/18722 0.00374391204950512 0.0572675813789406 GJA1/LRP1/LRP5/CTSV/SOX4/GPAM/EFNA5/SLC29A1/IGF1R/SERPINF1/KRT18/SPARC/PPARD/CYBA/MAP4K4/GSTP1/IRS2/GCLM/TCF7L2/BAD/NME1/ENY2 22 GO:0003208 cardiac ventricle morphogenesis 10/982 71/18722 0.00378829324054221 0.0576085642643387 LRP2/FGFR2/DSP/ISL1/SOX4/TGFBR3/CHD7/PKP2/FOXC1/RBPJ 10 GO:0003281 ventricular septum development 10/982 71/18722 0.00378829324054221 0.0576085642643387 LRP2/FGFR2/GJA5/SOX4/TGFBR3/LMO4/TBX3/MDM2/TRIP11/RBPJ 10 GO:0055008 cardiac muscle tissue morphogenesis 9/982 60/18722 0.0038452953927706 0.0583054092113124 LRP2/FGFR2/DSP/ISL1/TGFBR3/CHD7/PKP2/FOXC1/RBPJ 9 GO:0051235 maintenance of location 29/982 326/18722 0.00394400303274452 0.0591192994983624 FBN1/FBN2/GJA1/ITGAV/MCOLN3/SCIN/LTBP1/GAA/UBASH3B/MEST/PPARG/CHD7/ASPM/CDS1/SQLE/TMSB4X/ARHGAP21/HILPDA/P2RY6/PPARD/CYBA/PINK1/PNPLA2/ANK3/INSIG1/GSN/HSP90B1/GPAA1/PDPK1 29 GO:0007350 blastoderm segmentation 5/982 21/18722 0.00395564331382831 0.0591192994983624 NRP2/NRP1/SEMA3F/BASP1/TBX3 5 GO:0009127 purine nucleoside monophosphate biosynthetic process 5/982 21/18722 0.00395564331382831 0.0591192994983624 ADSL/PPAT/IMPDH2/ADK/ATIC 5 GO:0048485 sympathetic nervous system development 5/982 21/18722 0.00395564331382831 0.0591192994983624 NRP2/SOX4/NRP1/SEMA3F/NF1 5 GO:2000178 negative regulation of neural precursor cell proliferation 5/982 21/18722 0.00395564331382831 0.0591192994983624 SLC6A4/SPINT1/PTN/NF1/SPINT2 5 GO:0044262 cellular carbohydrate metabolic process 26/982 283/18722 0.00402910068405891 0.0600451119087179 SLC35B4/GAA/SORBS1/IL6ST/DDB1/AGL/ISYNA1/B3GNT3/SYNJ1/PHLDA2/PPP1R3E/P2RY6/C1QTNF1/IDH1/NUPR1/RANBP2/IRS2/EXT2/SCARB2/AKR1B1/RPE/ENOSF1/SLC5A3/BAD/LCMT1/GUSB 26 GO:0007219 Notch signaling pathway 18/982 172/18722 0.00409556653631683 0.0603552922092871 DTX4/APP/BMP7/NOTCH3/YAP1/MMP14/IL6ST/PERP/CD46/GALNT11/EPN2/PRKCI/CEBPA/YTHDF2/IFT74/METTL3/FOXC1/RBPJ 18 GO:0051897 positive regulation of protein kinase B signaling 14/982 120/18722 0.00410967815254457 0.0603552922092871 LRP2/EGFR/MET/TPBG/GCNT2/IGF1R/PTK2/FERMT2/C1QTNF1/PDGFA/PINK1/ITGB1/RICTOR/TCF7L2 14 GO:0015865 purine nucleotide transport 6/982 30/18722 0.00411934126275043 0.0603552922092871 GJA1/SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17 6 GO:0031571 mitotic G1 DNA damage checkpoint signaling 6/982 30/18722 0.00411934126275043 0.0603552922092871 SOX4/CCND1/MDM2/TRIAP1/PLK2/GTSE1 6 GO:0061384 heart trabecula morphogenesis 6/982 30/18722 0.00411934126275043 0.0603552922092871 ADAMTS1/BMP7/TGFBR3/CHD7/ADGRG6/RBPJ 6 GO:0070229 negative regulation of lymphocyte apoptotic process 6/982 30/18722 0.00411934126275043 0.0603552922092871 GPAM/EFNA1/SLC39A10/CCL5/IRS2/BCL10 6 GO:0007043 cell-cell junction assembly 16/982 146/18722 0.00421067019962188 0.0615206043731869 GJA1/LSR/GJA5/CLDN4/DLG5/CLDN19/JAM3/MARVELD3/TJP1/PARD3/RAB13/MPP7/CLDN7/PKP2/EPB41L3/F11R 16 GO:0031345 negative regulation of cell projection organization 19/982 186/18722 0.00422823641488556 0.0616046959219081 SEMA6D/KANK1/SEMA6A/LRP1/TACSTD2/YAP1/NRP1/SEMA3F/SEMA4C/B2M/ID1/TSKU/LIMK2/EFNA1/MDM2/MAP4K4/DENND5A/VIM/ITM2C 19 GO:0002791 regulation of peptide secretion 20/982 200/18722 0.00431708748656354 0.0627092202476842 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 20 GO:0006835 dicarboxylic acid transport 11/982 84/18722 0.00435217474979215 0.0627092202476842 LRP2/GJA1/SLC26A2/SLC19A1/SLC25A13/FOLR1/SLC1A3/SLC13A3/SLC1A5/ITGB1/LRRC8D 11 GO:0032508 DNA duplex unwinding 11/982 84/18722 0.00435217474979215 0.0627092202476842 CHD7/POLQ/MCM2/CHTF8/WRNIP1/NAV2/RAD54L2/TOP2A/DHX9/RAD50/DDX1 11 GO:0001823 mesonephros development 12/982 96/18722 0.00436208340970528 0.0627092202476842 LGR4/PBX1/KIF26B/FGFR2/TACSTD2/BMP7/LAMA5/MAGED1/GLI3/BASP1/SMAD5/FOXC1 12 GO:0014037 Schwann cell differentiation 7/982 40/18722 0.00436415777413907 0.0627092202476842 ITGB4/DAG1/GPC1/NF1/ERBB3/PARD3/ADGRG6 7 GO:0042552 myelination 15/982 134/18722 0.00450038340410934 0.064329426970451 ITGB4/DAG1/GPC1/PTN/NF1/JAM3/CYFIP1/TNFRSF21/MARVELD1/DEGS1/MAL2/PARD3/ADGRG6/EPB41L3/AFG3L2 15 GO:0001889 liver development 16/982 147/18722 0.00450157991645219 0.064329426970451 EGFR/MET/LSR/COBL/TGFBR3/PTN/NF1/HRAS/PRKCSH/GLI3/CCND1/CEBPA/KRT18/NPHP3/SEC63/ASS1 16 GO:0005996 monosaccharide metabolic process 24/982 257/18722 0.0045597054403084 0.0649820316301875 SLC35B4/LRP5/GAA/SORBS1/SLC25A13/DDB1/SLC2A1/FUT8/PHLDA2/PPP1R3E/SLC25A1/PPARD/C1QTNF1/RPIA/MAN2B2/FUCA1/PMM2/RANBP2/IRS2/INPPL1/AKR1B1/RPE/BAD/LCMT1 24 GO:0072089 stem cell proliferation 10/982 73/18722 0.00464077693698141 0.0659572002814579 GJA1/RNF43/YAP1/FERMT1/FBLN1/ZNRF3/FERMT2/TBX3/YTHDF2/CCNE1 10 GO:0014909 smooth muscle cell migration 12/982 97/18722 0.00474666735686362 0.0664807300603709 ADAMTS1/SEMA6D/LRP1/NRP1/GNA12/FOXO4/P2RY6/PPARD/MDM2/CCL5/PDGFA/GSTP1 12 GO:0060113 inner ear receptor cell differentiation 9/982 62/18722 0.0048079848867564 0.0664807300603709 MCOLN3/NAGLU/MYO7A/ESRP1/TSKU/TRIOBP/TPRN/TRIP11/RBPJ 9 GO:0090087 regulation of peptide transport 20/982 202/18722 0.00482464957183589 0.0664807300603709 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 20 GO:0071214 cellular response to abiotic stimulus 29/982 331/18722 0.00488056353234048 0.0664807300603709 GJA1/DAG1/NET1/EGFR/TMEM150C/YAP1/MME/PTPRK/EIF2AK4/DDB1/ADIRF/PTN/SLC2A1/GNA11/HRAS/CLN3/MDM2/TRIAP1/CYBA/ATR/SLC38A2/METTL3/USP47/AKR1B1/OPN3/BAD/F11R/LRRC8D/BCL10 29 GO:0104004 cellular response to environmental stimulus 29/982 331/18722 0.00488056353234048 0.0664807300603709 GJA1/DAG1/NET1/EGFR/TMEM150C/YAP1/MME/PTPRK/EIF2AK4/DDB1/ADIRF/PTN/SLC2A1/GNA11/HRAS/CLN3/MDM2/TRIAP1/CYBA/ATR/SLC38A2/METTL3/USP47/AKR1B1/OPN3/BAD/F11R/LRRC8D/BCL10 29 GO:0006779 porphyrin-containing compound biosynthetic process 6/982 31/18722 0.00488532846643031 0.0664807300603709 ALAD/NFE2L1/SLC11A2/PPOX/SUCLA2/ALAS1 6 GO:0030201 heparan sulfate proteoglycan metabolic process 6/982 31/18722 0.00488532846643031 0.0664807300603709 EXTL2/GPC1/GLCE/XYLT1/EXT2/TCF7L2 6 GO:0033014 tetrapyrrole biosynthetic process 6/982 31/18722 0.00488532846643031 0.0664807300603709 ALAD/NFE2L1/SLC11A2/PPOX/SUCLA2/ALAS1 6 GO:0044819 mitotic G1/S transition checkpoint signaling 6/982 31/18722 0.00488532846643031 0.0664807300603709 SOX4/CCND1/MDM2/TRIAP1/PLK2/GTSE1 6 GO:0071711 basement membrane organization 6/982 31/18722 0.00488532846643031 0.0664807300603709 LAMB1/DAG1/FERMT1/SPINT2/ITGB1/COL4A1 6 GO:0090162 establishment of epithelial cell polarity 6/982 31/18722 0.00488532846643031 0.0664807300603709 FERMT1/FRMD4A/FAT1/PARD3/CYTH3/FRMD4B 6 GO:0060713 labyrinthine layer morphogenesis 5/982 22/18722 0.00490119339788923 0.0664807300603709 FGFR2/BMP7/SPINT1/SPINT2/ADM 5 GO:1900120 regulation of receptor binding 5/982 22/18722 0.00490119339788923 0.0664807300603709 NRP1/B2M/PTPRF/PHLDA2/ANXA2 5 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 4/982 14/18722 0.00493252349182583 0.0664807300603709 SERPINH1/TSKU/AXIN2/TRIP11 4 GO:0010421 hydrogen peroxide-mediated programmed cell death 4/982 14/18722 0.00493252349182583 0.0664807300603709 MET/PAWR/HDAC6/PINK1 4 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 4/982 14/18722 0.00493252349182583 0.0664807300603709 KANK1/TACSTD2/FBLN1/EFNA5 4 GO:0046341 CDP-diacylglycerol metabolic process 4/982 14/18722 0.00493252349182583 0.0664807300603709 GPAM/CDS1/AGPAT1/CDIPT 4 GO:0070141 response to UV-A 4/982 14/18722 0.00493252349182583 0.0664807300603709 EGFR/MME/CCND1/OPN3 4 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/982 14/18722 0.00493252349182583 0.0664807300603709 KANK1/TACSTD2/FBLN1/EFNA5 4 GO:1901857 positive regulation of cellular respiration 4/982 14/18722 0.00493252349182583 0.0664807300603709 IL10RB/PINK1/NUPR1/OPN3 4 GO:0009167 purine ribonucleoside monophosphate metabolic process 7/982 41/18722 0.00502926896485619 0.0676099662904378 ADSL/TJP2/MPP1/PPAT/IMPDH2/ADK/ATIC 7 GO:0032869 cellular response to insulin stimulus 20/982 203/18722 0.00509633032237446 0.0683021744890587 KANK1/SORBS1/PPARG/FER/CYFIP1/GAB1/IGF1R/PRKCI/ATP2B1/FOXO4/RAB13/ESRRA/BCAR3/TBC1D4/RAB31/GSTP1/PPAT/INSIG1/IRS2/PDPK1 20 GO:0006635 fatty acid beta-oxidation 10/982 74/18722 0.00512004413827108 0.0683021744890587 SLC27A2/ACADS/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/HADHB 10 GO:0048332 mesoderm morphogenesis 10/982 74/18722 0.00512004413827108 0.0683021744890587 ITGB4/GJA1/WLS/FGFR2/BMP7/TBX3/ITGB1/EXT2/FOXC1/TXNRD1 10 GO:1903510 mucopolysaccharide metabolic process 11/982 86/18722 0.00521536122595203 0.0693962350881781 ITIH5/CHPF/GNS/B3GNT3/DSEL/B4GAT1/GLCE/CLTC/XYLT1/EXT2/ST3GAL6 11 GO:0030041 actin filament polymerization 19/982 190/18722 0.00531991140450859 0.070607271974343 KANK1/COBL/KANK4/SCIN/RASA1/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/EPS8/MSRB2/DIAPH3/GSN/RICTOR/TRIM27 19 GO:0010718 positive regulation of epithelial to mesenchymal transition 8/982 52/18722 0.00537372052387485 0.0711404219607391 BMP7/ISL1/GCNT2/DAB2/AXIN2/FERMT2/FOXC1/TCF7L2 8 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 13/982 111/18722 0.00539554311992465 0.0712484883886759 PLXNB1/EGFR/PIP5K1A/ERBB3/IGF1R/FLT1/PTK2/PPARD/CCL5/PDGFA/STAMBP/PIP5K1B/HCST 13 GO:0061008 hepaticobiliary system development 16/982 150/18722 0.00547419521565559 0.0721045511233828 EGFR/MET/LSR/COBL/TGFBR3/PTN/NF1/HRAS/PRKCSH/GLI3/CCND1/CEBPA/KRT18/NPHP3/SEC63/ASS1 16 GO:0097237 cellular response to toxic substance 14/982 124/18722 0.00551074038730655 0.0722865606980221 BMP7/ABCG2/PPP1R9A/MGST3/PTGES/GSTZ1/GPX8/PINK1/PRDX1/PRDX4/GSTP1/PRDX5/TXNRD2/TXNRD1 14 GO:0010977 negative regulation of neuron projection development 15/982 137/18722 0.00552958928652431 0.0722865606980221 SEMA6D/KANK1/SEMA6A/LRP1/NRP1/SEMA3F/SEMA4C/B2M/TSKU/EFNA1/MDM2/MAP4K4/DENND5A/VIM/ITM2C 15 GO:0030879 mammary gland development 15/982 137/18722 0.00552958928652431 0.0722865606980221 PRLR/LRP5/FGFR2/KDM5B/ELF3/SLC29A1/GLI3/CCND1/TBX3/BRCA2/PPAT/ARHGAP5/IRS2/CDO1/NME1 15 GO:0006024 glycosaminoglycan biosynthetic process 10/982 75/18722 0.00563723138186059 0.0735094972194621 CHPF/GCNT2/B3GNT3/DSEL/B4GAT1/GLCE/CLTC/XYLT1/EXT2/ST3GAL6 10 GO:0097191 extrinsic apoptotic signaling pathway 21/982 219/18722 0.00568600032610397 0.0739605428951578 ITGAV/ITGA6/PARP2/YAP1/NRP1/CTTN/ERBB3/TIMP3/IFI6/KRT18/LMNA/ZDHHC3/GSTP1/PSME3/GCLM/TCF7L2/KRT8/BAD/ITM2C/PDPK1/BCL10 21 GO:0051497 negative regulation of stress fiber assembly 6/982 32/18722 0.00575093092155858 0.0746190439971382 MET/TACSTD2/PPP1R9A/TJP1/PPFIA1/F11R 6 GO:0033002 muscle cell proliferation 23/982 248/18722 0.00587723493685652 0.0760686288601578 ADAMTS1/GJA1/EGFR/SKP2/FGFR2/YAP1/GNA12/TGFBR3/PPARG/COMT/TGM2/P2RY6/PPARD/MDM2/CCL5/CYBA/GSTP1/AKR1B1/DNMT1/FOXC1/TCF7L2/VGLL4/RBPJ 23 GO:0044706 multi-multicellular organism process 21/982 220/18722 0.00598540362288796 0.077038604615913 ITGB4/GJA1/NR2F2/SLC6A4/PRLR/CTSV/SLC19A1/CLDN4/FBLN1/TEAD3/PTN/SLC2A1/ADM/COMT/PPARD/SLC38A2/PPAT/TRIM28/BSG/AKR1B1/PGF 21 GO:0048705 skeletal system morphogenesis 21/982 220/18722 0.00598540362288796 0.077038604615913 FBN2/LRP5/FGFR2/BMP7/SERPINH1/MMP14/RDH10/TSKU/DLX5/TFAP2A/GLI3/AXIN2/SLC39A1/SLC39A3/WDR48/INSIG1/EXT2/INPPL1/GLG1/FOXC1/TRIP11 21 GO:0003283 atrial septum development 5/982 23/18722 0.00599648647892268 0.077038604615913 GJA5/ISL1/SOX4/MDM2/NPHP3 5 GO:0046883 regulation of hormone secretion 23/982 249/18722 0.00616456121699921 0.0790033201667515 GJA1/EGFR/LRP1/LRP5/KDM5B/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/SNX4/TARDBP/PPARD/C1QTNF1/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 23 GO:0072028 nephron morphogenesis 10/982 76/18722 0.00619430883829062 0.079189987501284 LGR4/PBX1/IRX2/KIF26B/TACSTD2/BMP7/LAMA5/MAGED1/GLI3/AHI1 10 GO:0021915 neural tube development 16/982 152/18722 0.00621253822884533 0.079228849392805 LRP2/COBL/BMP7/SPINT1/SOX4/DVL3/SEMA4C/FOLR1/SPINT2/ADM/PLXNB2/GLI3/LMO4/FZD6/NPHP3/BCL10 16 GO:0008406 gonad development 21/982 221/18722 0.00629764103245324 0.0801182820128686 LRP2/ADAMTS1/NR2F2/CTSV/MMP14/ADGRG1/ASPM/RDH10/TFAP2C/RHOBTB3/SPATA2/CCND1/RAB13/BASP1/IDH1/NUPR1/PRDX4/BRCA2/WDR48/FOXC1/RRM1 21 GO:0031667 response to nutrient levels 38/982 474/18722 0.00631672363830389 0.0801655243245574 EGFR/SLC6A4/ADRB1/CTSV/BMP7/SLC16A1/EIF2AK4/PPARG/FOLR1/PTN/SLC2A1/WIPI2/ALAD/ADM/AGL/LDLR/ATP2B1/ADSL/GSS/TFEB/PAGE4/FOXO4/COMT/CCND1/KRT18/SPARC/PPARD/MDM2/TRIM24/CYBA/GABARAPL1/NENF/GSTP1/SLC38A2/GCLM/RRAGA/ASS1/BCL10 38 GO:0042159 lipoprotein catabolic process 4/982 15/18722 0.00645022509574133 0.0804889332521214 ABHD12/NOTUM/LDLR/LYPLA1 4 GO:0043584 nose development 4/982 15/18722 0.00645022509574133 0.0804889332521214 CHD7/RDH10/DLX5/GLI3 4 GO:0045217 cell-cell junction maintenance 4/982 15/18722 0.00645022509574133 0.0804889332521214 TJP1/FERMT2/KIFC3/MTSS1 4 GO:0070071 proton-transporting two-sector ATPase complex assembly 4/982 15/18722 0.00645022509574133 0.0804889332521214 ATP6V1B1/ATPAF1/TM9SF4/VMA21 4 GO:0097468 programmed cell death in response to reactive oxygen species 4/982 15/18722 0.00645022509574133 0.0804889332521214 MET/PAWR/HDAC6/PINK1 4 GO:0098760 response to interleukin-7 4/982 15/18722 0.00645022509574133 0.0804889332521214 P4HB/RAD23B/IL2RG/ATIC 4 GO:0098761 cellular response to interleukin-7 4/982 15/18722 0.00645022509574133 0.0804889332521214 P4HB/RAD23B/IL2RG/ATIC 4 GO:0043542 endothelial cell migration 25/982 279/18722 0.00648705400269329 0.0805230229390606 PLPP3/NR2F2/MET/NRP2/NRP1/PPARG/PTN/NF1/AMOT/ID1/TMSB4X/SERPINF1/EFNA1/EPHB4/PTK2/RAB13/SPARC/LGMN/ITGB1/GRN/PLK2/FSTL1/DPP4/PDPK1/ANXA3 25 GO:0031346 positive regulation of cell projection organization 30/982 353/18722 0.00651458913264288 0.0805230229390606 PLXNB1/TENM3/OBSL1/LRP1/COBL/BMP7/PROM2/ITGA6/DVL3/NRP1/ANKRD27/CUX1/PTN/CYFIP1/PPP1R9A/SERPINF1/HRAS/PRKCI/PLXNB2/NCKAP1/WASL/FNBP1L/EPS8/EPS8L2/MAP3K13/GRN/CREB3L2/SCARB2/NME1/CEP135 30 GO:0030072 peptide hormone secretion 22/982 236/18722 0.00655845382144474 0.0805230229390606 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/CAMK2G/FAM3B/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 22 GO:0048738 cardiac muscle tissue development 22/982 236/18722 0.00655845382144474 0.0805230229390606 LRP2/GJA1/OBSL1/FGFR2/GJA5/DSG2/BMP7/DSP/ISL1/PARP2/YAP1/TGFBR3/CHD7/TBX3/LMNA/ITGB1/PKP2/CBY1/SMAD5/FOXC1/VGLL4/RBPJ 22 GO:0007033 vacuole organization 18/982 180/18722 0.00656102084913741 0.0805230229390606 HOOK2/NAGLU/SYT7/GAA/MYO7A/WIPI2/HOOK1/TFEB/CLN3/HOOK3/PINK1/TBC1D12/NUPR1/GABARAPL1/GRN/SCARB2/ANXA2/PHF23 18 GO:0010721 negative regulation of cell development 18/982 180/18722 0.00656102084913741 0.0805230229390606 FBN1/SEMA6D/KANK1/SEMA6A/PRTG/TACSTD2/BMP7/NRP1/SEMA3F/FBLN1/SEMA4C/PTN/NF1/EFNA5/B2M/ID1/LDLR/HOOK3 18 GO:0048660 regulation of smooth muscle cell proliferation 18/982 180/18722 0.00656102084913741 0.0805230229390606 ADAMTS1/GJA1/EGFR/SKP2/FGFR2/GNA12/PPARG/COMT/TGM2/P2RY6/PPARD/MDM2/CCL5/CYBA/GSTP1/AKR1B1/DNMT1/TCF7L2 18 GO:0048645 animal organ formation 9/982 65/18722 0.00659096862770325 0.0807006862960097 LRP2/FGFR2/BMP7/ISL1/FOLR1/RDH10/GLI3/AXIN2/RBPJ 9 GO:0034110 regulation of homotypic cell-cell adhesion 6/982 33/18722 0.0067232572209949 0.0814568538825284 UBASH3B/IL6ST/C1QTNF1/CCL5/ANK3/F11R 6 GO:0048048 embryonic eye morphogenesis 6/982 33/18722 0.0067232572209949 0.0814568538825284 FBN1/FBN2/BMP7/EFEMP1/TFAP2A/MFAP5 6 GO:0015748 organophosphate ester transport 15/982 140/18722 0.00674103099636986 0.0814568538825284 GJA1/OSBPL10/SLC19A1/PLEKHA8/SLC25A36/TMEM30B/SLC29A1/LDLR/KCNN4/SLC25A4/TRIAP1/SLC35B2/ATP10D/SLC25A17/SCARB2 15 GO:0002244 hematopoietic progenitor cell differentiation 13/982 114/18722 0.0067464827336258 0.0814568538825284 SOX4/RBM47/ZFAT/JAM3/FLT1/ARMC6/EML1/YTHDF2/DHTKD1/TOP2A/METTL3/FOXC1/SLC7A6OS 13 GO:0007041 lysosomal transport 13/982 114/18722 0.0067464827336258 0.0814568538825284 LRP1/HOOK2/HGSNAT/HOOK1/ALS2/VIPAS39/CLN3/HOOK3/PINK1/PSAP/GRN/SCARB2/EHD3 13 GO:0021987 cerebral cortex development 13/982 114/18722 0.0067464827336258 0.0814568538825284 LAMB1/LRP1/TACC2/NF1/ADGRG1/SLC2A1/ASPM/BTBD3/GNG12/GLI3/SLC38A2/BAD/ATIC 13 GO:0006790 sulfur compound metabolic process 29/982 339/18722 0.00676395160518162 0.0814568538825284 SLC26A2/CHPF/SLC19A3/ACSS1/GPAM/GNS/B3GNT3/DSEL/GSS/B4GAT1/COMT/ACSF2/GLCE/MVK/GSTZ1/SLC25A1/XYLT1/SLC35B2/IDH1/SMS/GSTP1/EXT2/GCLM/SUCLA2/HSD17B12/TST/ST3GAL6/CDO1/GSTA4 29 GO:0072348 sulfur compound transport 8/982 54/18722 0.00677795800413657 0.0814568538825284 GJA1/SLC26A2/SLC19A3/ABCG2/SLC13A3/RACGAP1/SLC35B2/LRRC8D 8 GO:0031016 pancreas development 10/982 77/18722 0.00679327673291791 0.0814568538825284 MET/WLS/ISL1/SOX4/WFS1/CDK6/NPHP3/TCF7L2/BAD/PDPK1 10 GO:0052547 regulation of peptidase activity 37/982 461/18722 0.00685835906347037 0.0820486258602327 ITIH5/LRP1/APP/PCOLCE2/SPINT1/SERPINH1/CLDN4/APLP2/FBLN1/PPARG/ASPH/SPINT2/PERP/SERPINF1/EFNA1/TIMP3/DHCR24/IFI6/CRIM1/MDM2/TRIAP1/PEBP1/PINK1/LGMN/BCL2L13/CST3/GRN/PSME3/USP47/BIRC5/GSN/PRDX5/USP14/ANXA2/BAD/NLRP2/BCL10 37 GO:1901605 alpha-amino acid metabolic process 19/982 195/18722 0.00699930090729127 0.0835431430948084 GLDC/PLOD2/PSAT1/SLC25A13/COMT/CLN3/GSTZ1/GFPT1/RIMKLB/ASNSD1/SMS/AASDHPPT/PPAT/GCLM/TST/GCSH/CDO1/ASS1/AZIN1 19 GO:0008360 regulation of cell shape 16/982 154/18722 0.00702930369463809 0.0837096987927678 PLXNB1/DAG1/MYH10/RASA1/PTN/CYFIP1/PLXNB2/RHOBTB3/PTK2/RHOBTB1/FERMT2/EPS8/FMNL2/EPB41L3/F11R/RND3 16 GO:0050890 cognition 26/982 296/18722 0.00718611190128005 0.08538214049448 EGFR/SLC6A4/APP/MGAT3/TPBG/TUSC3/SHANK2/MME/EIF2AK4/CHD7/PTN/NF1/CYFIP1/B2M/PAK6/LDLR/SERPINF1/SYNJ1/COMT/CLN3/SLC11A2/FEN1/LGMN/UBA6/ITGB1/PLK2 26 GO:0003148 outflow tract septum morphogenesis 5/982 24/18722 0.00725309190276385 0.0855923670786009 LRP2/NRP2/FGFR2/ISL1/NRP1 5 GO:0071577 zinc ion transmembrane transport 5/982 24/18722 0.00725309190276385 0.0855923670786009 SLC39A11/SLC39A10/SLC39A1/SLC39A3/SLC39A7 5 GO:0072530 purine-containing compound transmembrane transport 5/982 24/18722 0.00725309190276385 0.0855923670786009 SLC19A1/SLC29A1/SLC25A4/SLC35B2/SLC25A17 5 GO:0014015 positive regulation of gliogenesis 9/982 66/18722 0.00728585333261096 0.0855923670786009 LRP2/DAG1/EGFR/ETV5/SPINT1/IL6ST/PTN/PRKCI/SYNJ1 9 GO:0045600 positive regulation of fat cell differentiation 9/982 66/18722 0.00728585333261096 0.0855923670786009 LRP5/BMP7/PPARG/ADIRF/CDS1/ZBTB7C/CEBPA/PPARD/KLF5 9 GO:0032392 DNA geometric change 11/982 90/18722 0.00734412566876007 0.0858900436956334 CHD7/POLQ/MCM2/CHTF8/WRNIP1/NAV2/RAD54L2/TOP2A/DHX9/RAD50/DDX1 11 GO:0034644 cellular response to UV 11/982 90/18722 0.00734412566876007 0.0858900436956334 MME/PTPRK/EIF2AK4/DDB1/PTN/MDM2/TRIAP1/ATR/METTL3/USP47/OPN3 11 GO:0031032 actomyosin structure organization 19/982 196/18722 0.00738201354515438 0.0861400059318238 FRMD6/MYH10/MET/OBSL1/TACSTD2/ITGB5/SORBS1/NRP1/PPP1R9A/TJP1/PDLIM1/CSRP2/FERMT2/RACGAP1/PPFIA1/ITGB1/EPB41L3/KRT8/F11R 19 GO:0009743 response to carbohydrate 23/982 253/18722 0.00743211681164463 0.0863853435232635 GJA1/COLEC12/LRP1/LRP5/CTSV/SOX4/GPAM/EFNA5/SLC29A1/IGF1R/SERPINF1/KRT18/SPARC/PPARD/CYBA/MAP4K4/GSTP1/IRS2/GCLM/TCF7L2/BAD/NME1/ENY2 23 GO:0032024 positive regulation of insulin secretion 10/982 78/18722 0.00743616166448338 0.0863853435232635 GJA1/LRP1/ISL1/SOX4/TARDBP/PPARD/TM7SF3/IRS2/TCF7L2/BAD 10 GO:0009126 purine nucleoside monophosphate metabolic process 7/982 44/18722 0.00748376787538944 0.0867451849734029 ADSL/TJP2/MPP1/PPAT/IMPDH2/ADK/ATIC 7 GO:0007009 plasma membrane organization 15/982 142/18722 0.00766065171198936 0.088598579445092 SPESP1/SYT7/FOLR1/DEGS1/WASL/FNBP1L/MYOF/CLN3/MICALL1/PACSIN2/EPB41L3/BIN3/ANK3/MTSS1/GSN 15 GO:1990000 amyloid fibril formation 6/982 34/18722 0.00780936768987886 0.0901187209522303 APP/SIAH1/B2M/LDLR/MDM2/GSN 6 GO:0042490 mechanoreceptor differentiation 9/982 67/18722 0.00803534379110659 0.092521751025192 MCOLN3/NAGLU/MYO7A/ESRP1/TSKU/TRIOBP/TPRN/TRIP11/RBPJ 9 GO:0006023 aminoglycan biosynthetic process 10/982 79/18722 0.00812501278170081 0.0931430036689042 CHPF/GCNT2/B3GNT3/DSEL/B4GAT1/GLCE/CLTC/XYLT1/EXT2/ST3GAL6 10 GO:0060420 regulation of heart growth 10/982 79/18722 0.00812501278170081 0.0931430036689042 GJA1/FGFR2/PARP2/YAP1/TGFBR3/DUSP9/BASP1/DUSP6/VGLL4/RBPJ 10 GO:0048659 smooth muscle cell proliferation 18/982 184/18722 0.00818374747047522 0.0932103414504379 ADAMTS1/GJA1/EGFR/SKP2/FGFR2/GNA12/PPARG/COMT/TGM2/P2RY6/PPARD/MDM2/CCL5/CYBA/GSTP1/AKR1B1/DNMT1/TCF7L2 18 GO:0009306 protein secretion 30/982 359/18722 0.00819674146281257 0.0932103414504379 GJA1/EGFR/MYH10/WLS/LRP1/CD200/LRP5/ISL1/SYT7/SOX4/FRMD4A/SLC16A1/EFNA5/CAMK2G/FAM3B/TVP23C/KCNN4/EXPH5/RAB13/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/CD2AP/TCF7L2/BAD/ENY2 30 GO:0007635 chemosensory behavior 4/982 16/18722 0.00824817049958868 0.0932103414504379 TPBG/ATP6V1B1/CHD7/WFS1 4 GO:0072148 epithelial cell fate commitment 4/982 16/18722 0.00824817049958868 0.0932103414504379 NR2F2/NRP1/ESRP1/RBPJ 4 GO:0097202 activation of cysteine-type endopeptidase activity 4/982 16/18722 0.00824817049958868 0.0932103414504379 ASPH/PERP/LGMN/BAD 4 GO:0048661 positive regulation of smooth muscle cell proliferation 12/982 104/18722 0.00825597732939078 0.0932103414504379 ADAMTS1/GJA1/EGFR/SKP2/FGFR2/TGM2/P2RY6/MDM2/CCL5/CYBA/AKR1B1/DNMT1 12 GO:1903076 regulation of protein localization to plasma membrane 12/982 104/18722 0.00825597732939078 0.0932103414504379 EGFR/LRP1/SORBS1/MMP14/DAB2/PRKCI/CLN3/CLTC/PPFIA1/ITGB1/LYPLA1/PDPK1 12 GO:0033674 positive regulation of kinase activity 37/982 467/18722 0.00836421366205599 0.094228376806229 DAG1/EGFR/MET/PRLR/FZD10/FGFR2/DVL3/MAGED1/EFNA5/PPP1R9A/ERBB3/TRAF4/ALS2/IGF1R/FLT1/HRAS/EFNA1/EPHB4/LMO4/PTK2/CCND1/MAP3K7/CD24/FERMT2/CCL5/PDGFA/MAP3K13/PINK1/RANBP2/VAV3/TPX2/RICTOR/CACUL1/BAD/PDPK1/RAD50/BCL10 37 GO:0007030 Golgi organization 16/982 157/18722 0.00841412994950349 0.0945864263289013 OBSL1/LMAN1/HOOK1/ARHGAP21/TMED4/CAMSAP2/KIFC3/PDE4DIP/COG4/LYSMD3/GORASP2/EHD3/TRIP11/GOLGB1/TMED9/HUWE1 16 GO:0045137 development of primary sexual characteristics 21/982 227/18722 0.00846351262329121 0.0948156832501959 LRP2/ADAMTS1/NR2F2/CTSV/MMP14/ADGRG1/ASPM/RDH10/TFAP2C/RHOBTB3/SPATA2/CCND1/RAB13/BASP1/IDH1/NUPR1/PRDX4/BRCA2/WDR48/FOXC1/RRM1 21 GO:0044088 regulation of vacuole organization 7/982 45/18722 0.00847087967687717 0.0948156832501959 PINK1/TBC1D12/NUPR1/GRN/SCARB2/ANXA2/PHF23 7 GO:0035592 establishment of protein localization to extracellular region 30/982 360/18722 0.00850922085378247 0.0950408907351806 GJA1/EGFR/MYH10/WLS/LRP1/CD200/LRP5/ISL1/SYT7/SOX4/FRMD4A/SLC16A1/EFNA5/CAMK2G/FAM3B/TVP23C/KCNN4/EXPH5/RAB13/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/CD2AP/TCF7L2/BAD/ENY2 30 GO:0015012 heparan sulfate proteoglycan biosynthetic process 5/982 25/18722 0.00868222687222945 0.0965596916109782 EXTL2/GLCE/XYLT1/EXT2/TCF7L2 5 GO:0031579 membrane raft organization 5/982 25/18722 0.00868222687222945 0.0965596916109782 CLN3/PACSIN2/GSN/FLOT2/ANXA2 5 GO:0002790 peptide secretion 22/982 242/18722 0.00871165394273919 0.0966808233304843 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/CAMK2G/FAM3B/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 22 GO:0070997 neuron death 30/982 361/18722 0.00883145731132311 0.0977123434966156 LRP1/CD200/APP/ISL1/PARP2/NRP1/RASA1/NF1/SIAH1/TNFRSF21/ERBB3/WFS1/SERPINF1/HRAS/PRKCI/TFAP2A/DHCR24/USP53/CLN3/CCL5/ATN1/PINK1/LGMN/NUPR1/RILPL1/NENF/GRN/GCLM/BAD/PDPK1 30 GO:0010812 negative regulation of cell-substrate adhesion 9/982 68/18722 0.00884206789309865 0.0977123434966156 KANK1/LRP1/TACSTD2/RASA1/MMP14/GCNT2/FBLN1/EFNA5/MAP4K4 9 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 14/982 131/18722 0.00886653622935156 0.0977755876792764 LRP2/FBN1/FBN2/LRP1/LTBP1/RASL11B/TGFBR3/PPARG/PEG10/DACT2/CRIM1/ZNF451/GLG1/PDPK1 14 GO:0032231 regulation of actin filament bundle assembly 12/982 105/18722 0.00889000300961078 0.0978275436669405 MET/TACSTD2/NRP1/SWAP70/SYNPO/PPP1R9A/ID1/TJP1/FERMT2/PPFIA1/MTSS1/F11R 12 GO:0001893 maternal placenta development 6/982 35/18722 0.0090162354812066 0.0985926294968001 GJA1/NR2F2/CTSV/PTN/PPARD/BSG 6 GO:0015695 organic cation transport 6/982 35/18722 0.0090162354812066 0.0985926294968001 SLC19A3/SLC29A1/ATP13A3/SLC44A1/SLC25A17/SLC38A2 6 GO:0032232 negative regulation of actin filament bundle assembly 6/982 35/18722 0.0090162354812066 0.0985926294968001 MET/TACSTD2/PPP1R9A/TJP1/PPFIA1/F11R 6 GO:0042593 glucose homeostasis 23/982 258/18722 0.00930886266532483 0.101579555778942 LRP1/LRP5/SOX4/SLC16A1/PPARG/EFNA5/SLC29A1/WFS1/IGF1R/FAM3B/SERPINF1/CEBPA/PPARD/CYBA/MAP4K4/IRS2/GCLM/TCF7L2/BAD/NME1/BACE2/ENY2/LRRC8D 23 GO:0045185 maintenance of protein location 11/982 93/18722 0.00934381398624069 0.10174808716541 FBN1/FBN2/GJA1/SCIN/LTBP1/TMSB4X/PINK1/ANK3/INSIG1/GSN/GPAA1 11 GO:0045851 pH reduction 7/982 46/18722 0.00955039663376385 0.103350350294009 ATP6V1B1/GPR89A/RAB38/CLN3/ATP6V1H/GRN/CLIC4 7 GO:0048701 embryonic cranial skeleton morphogenesis 7/982 46/18722 0.00955039663376385 0.103350350294009 FGFR2/MMP14/RDH10/TFAP2A/GLI3/SLC39A1/SLC39A3 7 GO:1900271 regulation of long-term synaptic potentiation 7/982 46/18722 0.00955039663376385 0.103350350294009 APP/MME/EIF2AK4/PTN/PPP1R9A/NSG1/LGMN 7 GO:0008064 regulation of actin polymerization or depolymerization 18/982 187/18722 0.00960118102223481 0.103540901891218 KANK1/KANK4/SCIN/RASA1/SWAP70/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/EPS8/LIMA1/GSN/RICTOR/TRIM27 18 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 10/982 81/18722 0.00964889909576252 0.103540901891218 FBN1/FBN2/LTBP1/RASL11B/TGFBR3/PPARG/PEG10/ZNF451/GLG1/PDPK1 10 GO:0048708 astrocyte differentiation 10/982 81/18722 0.00964889909576252 0.103540901891218 EGFR/LRP1/APP/IL6ST/NF1/LDLR/CDK6/GRN/VIM/BACE2 10 GO:0071260 cellular response to mechanical stimulus 10/982 81/18722 0.00964889909576252 0.103540901891218 GJA1/DAG1/EGFR/TMEM150C/SLC2A1/CYBA/SLC38A2/BAD/F11R/BCL10 10 GO:0009314 response to radiation 36/982 456/18722 0.00969910700408098 0.103540901891218 NET1/EGFR/APP/LRP5/SCARA3/YAP1/MME/PTPRK/EIF2AK4/DDB1/ADIRF/PTN/NF1/SLC1A3/CDS1/ALAD/GNA11/HRAS/BRCC3/CCND1/FEN1/MDM2/UBE4B/TRIAP1/CYBA/ITGB1/ATR/TOPBP1/BRCA2/METTL3/NR2F6/USP47/OPN3/F11R/IKBIP/RRM1 36 GO:0015807 L-amino acid transport 9/982 69/18722 0.00970866562157321 0.103540901891218 SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/SLC7A6/ITGB1/SLC38A2/SLC7A2 9 GO:0045665 negative regulation of neuron differentiation 9/982 69/18722 0.00970866562157321 0.103540901891218 PBX1/SLC6A4/APP/BMP7/ISL1/EIF2AK4/ASPM/B2M/GLI3 9 GO:0033500 carbohydrate homeostasis 23/982 259/18722 0.009726810185333 0.103540901891218 LRP1/LRP5/SOX4/SLC16A1/PPARG/EFNA5/SLC29A1/WFS1/IGF1R/FAM3B/SERPINF1/CEBPA/PPARD/CYBA/MAP4K4/IRS2/GCLM/TCF7L2/BAD/NME1/BACE2/ENY2/LRRC8D 23 GO:0048813 dendrite morphogenesis 15/982 146/18722 0.00979902480131757 0.104097175893427 OBSL1/TPBG/NRP1/ANKRD27/CUX1/PTN/PPP1R9A/ID1/BTBD3/EFNA1/WASL/SLC11A2/HDAC6/ITGB1/RERE 15 GO:0050808 synapse organization 34/982 426/18722 0.0100469507032363 0.106324895023359 PLXNB1/DAG1/CDH1/MYH10/OBSL1/APP/NRP2/VSTM5/TPBG/SHANK2/NRP1/SEMA3F/SYNPO/PTN/DLG5/CYFIP1/PPP1R9A/CTTN/ALS2/IGF1R/EFNA1/PLXNB2/PTPRF/WASL/ACTN1/CLN3/HDAC6/SPARC/LGMN/PPFIA1/COL4A1/AFG3L2/ANK3/RAB17 34 GO:0032388 positive regulation of intracellular transport 19/982 202/18722 0.0100494964046235 0.106324895023359 CDH1/TCAF1/PGAP1/TMEM30B/MIEF1/DAB2/HRAS/GLI3/TARDBP/TM9SF4/MDM2/PINK1/DHX9/ANK3/TRIM28/LEPROT/TCF7L2/ANXA2/HUWE1 19 GO:0006575 cellular modified amino acid metabolic process 18/982 188/18722 0.0101150170511044 0.106585715027395 OSBPL10/PLOD2/SLC19A1/ABHD12/FOLR1/GSS/ALDH7A1/GSTZ1/CKMT1B/IDH1/AASDHPPT/GSTP1/SERINC2/CPQ/GCLM/GSTA4/ASS1/ATIC 18 GO:0030832 regulation of actin filament length 18/982 188/18722 0.0101150170511044 0.106585715027395 KANK1/KANK4/SCIN/RASA1/SWAP70/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/EPS8/LIMA1/GSN/RICTOR/TRIM27 18 GO:0048593 camera-type eye morphogenesis 13/982 120/18722 0.0102456337343969 0.107216706368976 TENM3/OBSL1/LRP5/BMP7/NAGLU/PTN/NF1/FAT1/TSKU/TFAP2A/GLI3/BCAR3/AHI1 13 GO:0019883 antigen processing and presentation of endogenous antigen 5/982 26/18722 0.0102946749896337 0.107216706368976 B2M/HLA-B/HLA-A/HLA-C/HLA-E 5 GO:0046697 decidualization 5/982 26/18722 0.0102946749896337 0.107216706368976 GJA1/CTSV/PTN/PPARD/BSG 5 GO:0048843 negative regulation of axon extension involved in axon guidance 5/982 26/18722 0.0102946749896337 0.107216706368976 SEMA6D/SEMA6A/NRP1/SEMA3F/SEMA4C 5 GO:0042339 keratan sulfate metabolic process 4/982 17/18722 0.0103453323230698 0.107216706368976 GNS/B3GNT3/B4GAT1/ST3GAL6 4 GO:0048532 anatomical structure arrangement 4/982 17/18722 0.0103453323230698 0.107216706368976 NRP2/NRP1/SEMA3F/TFAP2A 4 GO:0009225 nucleotide-sugar metabolic process 6/982 36/18722 0.0103507090739488 0.107216706368976 EXTL2/UGGT2/DPAGT1/FUT8/GFPT1/PMM2 6 GO:0010092 specification of animal organ identity 6/982 36/18722 0.0103507090739488 0.107216706368976 LRP2/FGFR2/ISL1/GLI3/AXIN2/RBPJ 6 GO:0031331 positive regulation of cellular catabolic process 34/982 427/18722 0.0103863405097912 0.107216706368976 LRP2/LRP1/APP/KCNQ1OT1/SH3BP4/TRIML2/LIN28B/TMTC3/DAB2/LDLR/TRIM6/RNF128/TFEB/SLC25A4/PTK2/MAP3K7/CEBPA/SH3D19/PUM1/TARDBP/YTHDF2/MDM2/MAGEF1/PINK1/PNPLA2/NUPR1/PLK2/METTL3/IRS2/PTTG1IP/FBXO22/TRIM27/BAD/VGLL4 34 GO:0060041 retina development in camera-type eye 15/982 147/18722 0.0104010071745978 0.107216706368976 OBSL1/LRP5/NAGLU/NRP1/CHD7/PTN/ACVR2B/SERPINF1/ATP2B1/TFAP2A/COL4A1/AHI1/IMPDH2/CLIC4/RRM1 15 GO:1902652 secondary alcohol metabolic process 15/982 147/18722 0.0104010071745978 0.107216706368976 APP/LRP5/SQLE/TSKU/LDLR/DHCR24/NFE2L1/MVK/CEBPA/PPARD/ACADVL/IDH1/RXRA/LIMA1/INSIG1 15 GO:0051402 neuron apoptotic process 22/982 246/18722 0.0104425803604212 0.107432937199126 LRP1/APP/ISL1/NRP1/RASA1/NF1/SIAH1/TNFRSF21/ERBB3/WFS1/HRAS/PRKCI/TFAP2A/USP53/CLN3/ATN1/PINK1/LGMN/NUPR1/GRN/GCLM/PDPK1 22 GO:0043242 negative regulation of protein-containing complex disassembly 10/982 82/18722 0.0104881092238979 0.107688932503644 SCIN/SWAP70/TRIOBP/HDAC6/CAMSAP2/EPS8/LIMA1/TPX2/GSN/PHF23 10 GO:0060415 muscle tissue morphogenesis 9/982 70/18722 0.0106377825490315 0.109011146907167 LRP2/FGFR2/DSP/ISL1/TGFBR3/CHD7/PKP2/FOXC1/RBPJ 9 GO:0061041 regulation of wound healing 14/982 134/18722 0.0107243752258743 0.109281620500103 GJA1/PLPP3/KANK1/FERMT1/UBASH3B/CLDN4/CLDN19/HRAS/PTK2/FERMT2/C1QTNF1/PDGFA/ITGB1/ANXA2 14 GO:0010761 fibroblast migration 7/982 47/18722 0.0107270302331389 0.109281620500103 PIP5K1A/GNA12/FER/PDLIM1/PTK2/CLN3/ITGB1 7 GO:0048483 autonomic nervous system development 7/982 47/18722 0.0107270302331389 0.109281620500103 NRP2/SOX4/NRP1/SEMA3F/NF1/TFAP2A/NAV2 7 GO:0006650 glycerophospholipid metabolic process 26/982 306/18722 0.0108126059275691 0.109938698865888 PISD/PIP5K1A/OSBPL10/SOCS6/PGAP2/PGAP1/ABHD12/GPAM/TMEM150A/CDS1/PIGU/SOCS7/AGPAT1/LDLR/SYNJ1/CDIPT/RAB38/CLN3/CHPT1/SLC44A1/PDGFA/PIGF/SERINC2/INPPL1/GPAA1/PIP5K1B 26 GO:0051384 response to glucocorticoid 15/982 148/18722 0.0110317185671119 0.111948334719953 EGFR/CTSV/ISL1/ALAD/ADM/AGL/SERPINF1/ATP2B1/CCND1/SPARC/GSTP1/CDO1/BAD/ASS1/ANXA3 15 GO:0009636 response to toxic substance 23/982 262/18722 0.0110726212821645 0.112145228364602 CDH1/SLC6A4/BMP7/KDM5B/ABCG2/PPP1R9A/ALAD/MGST3/PTGES/GSTZ1/GPX8/MDM2/CCL5/PINK1/NUPR1/PRDX1/PRDX4/GSTP1/DHX15/PRDX5/TXNRD2/ASS1/TXNRD1 23 GO:0042157 lipoprotein metabolic process 14/982 135/18722 0.0114070045159846 0.115308014642201 ITGAV/LRP1/PGAP2/PGAP1/ABHD12/NOTUM/WIPI2/PIGU/LDLR/OLR1/PIGF/ZDHHC3/GPAA1/LYPLA1 14 GO:0009746 response to hexose 20/982 219/18722 0.0114446897236035 0.115465186843937 GJA1/LRP1/LRP5/CTSV/SOX4/GPAM/EFNA5/SLC29A1/IGF1R/SERPINF1/KRT18/PPARD/CYBA/MAP4K4/IRS2/GCLM/TCF7L2/BAD/NME1/ENY2 20 GO:0090303 positive regulation of wound healing 8/982 59/18722 0.0114906492629076 0.115705070570127 PLPP3/KANK1/FERMT1/CLDN4/HRAS/PTK2/FERMT2/ITGB1 8 GO:0072078 nephron tubule morphogenesis 9/982 71/18722 0.0116320632551025 0.116903356336445 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LAMA5/MAGED1/GLI3/AHI1 9 GO:0035282 segmentation 11/982 96/18722 0.0117392827915498 0.117119579261763 IRX2/NRP2/COBL/NRP1/SEMA3F/LRP6/AXIN2/BASP1/TBX3/FOXC1/RBPJ 11 GO:0042472 inner ear morphogenesis 11/982 96/18722 0.0117392827915498 0.117119579261763 FGFR2/ATP6V1B1/DLX6/CHD7/MYO7A/TRIOBP/DLX5/TFAP2A/TPRN/FZD6/INSIG1 11 GO:0003161 cardiac conduction system development 6/982 37/18722 0.0118194764170842 0.117119579261763 GJA1/GJA5/DSG2/ISL1/TBX3/SMAD5 6 GO:0043687 post-translational protein modification 6/982 37/18722 0.0118194764170842 0.117119579261763 FN3K/WIPI2/VIPAS39/STT3A/UCHL3/LCMT1 6 GO:0048846 axon extension involved in axon guidance 6/982 37/18722 0.0118194764170842 0.117119579261763 SEMA6D/SEMA6A/NRP2/NRP1/SEMA3F/SEMA4C 6 GO:1902284 neuron projection extension involved in neuron projection guidance 6/982 37/18722 0.0118194764170842 0.117119579261763 SEMA6D/SEMA6A/NRP2/NRP1/SEMA3F/SEMA4C 6 GO:0010976 positive regulation of neuron projection development 16/982 163/18722 0.0118332090243384 0.117119579261763 TENM3/LRP1/COBL/BMP7/ITGA6/ANKRD27/PTN/CYFIP1/PPP1R9A/SERPINF1/PRKCI/PLXNB2/GRN/CREB3L2/SCARB2/NME1 16 GO:0071322 cellular response to carbohydrate stimulus 16/982 163/18722 0.0118332090243384 0.117119579261763 COLEC12/LRP1/LRP5/SOX4/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/BAD/NME1/ENY2 16 GO:0015833 peptide transport 23/982 264/18722 0.0120503349501574 0.11841525196737 GJA1/EGFR/LRP1/LRP5/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/CAMK2G/FAM3B/SLC13A3/TARDBP/PPARD/CCL5/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2 23 GO:0032868 response to insulin 23/982 264/18722 0.0120503349501574 0.11841525196737 KANK1/SORBS1/PPARG/FER/SLC2A1/CYFIP1/GAB1/ADM/IGF1R/PRKCI/ATP2B1/FOXO4/RAB13/ESRRA/BCAR3/TBC1D4/RAB31/GSTP1/PPAT/INSIG1/IRS2/INPPL1/PDPK1 23 GO:0006783 heme biosynthetic process 5/982 27/18722 0.0121007131626008 0.11841525196737 ALAD/NFE2L1/SLC11A2/PPOX/ALAS1 5 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 5/982 27/18722 0.0121007131626008 0.11841525196737 PBX1/APP/BRD4/MTA3/CCND1 5 GO:0098901 regulation of cardiac muscle cell action potential 5/982 27/18722 0.0121007131626008 0.11841525196737 GJA5/DSG2/DSP/DSC2/PKP2 5 GO:0003158 endothelium development 14/982 136/18722 0.0121230338478864 0.11841525196737 GJA1/NR2F2/MET/GJA5/NRP1/PTN/ACVR2B/ID1/TJP1/TJP2/FSTL1/CLIC4/F11R/RBPJ 14 GO:1900180 regulation of protein localization to nucleus 14/982 136/18722 0.0121230338478864 0.11841525196737 CDH1/TRIM29/YAP1/TFRC/FERMT1/MAGED1/LATS2/LIMK2/GLI3/TARDBP/FERMT2/LMNA/TRIM28/CD2AP 14 GO:0006970 response to osmotic stress 10/982 84/18722 0.0123315529666621 0.120226879017027 EGFR/SLC2A1/MARVELD3/NFAT5/MAP7/CLN3/AKR1B1/BAD/PDPK1/LRRC8D 10 GO:0010876 lipid localization 35/982 448/18722 0.0123695209194183 0.120372054320309 ITGAV/LRP1/SLC27A2/OSBPL10/KDM5B/SYT7/MEST/PPARG/SPNS1/PLEKHA8/SLC2A1/LRP6/CDS1/TMEM30B/SQLE/TSKU/LDLR/PTGES/PLA2G12A/KCNN4/CLN3/HILPDA/PPARD/C1QTNF1/TRIAP1/PNPLA2/ATP10D/SLC25A17/RXRA/NME4/PSAP/LIMA1/IRS2/SCARB2/ANXA2 35 GO:0010811 positive regulation of cell-substrate adhesion 13/982 123/18722 0.012456954274256 0.120997157345474 CCDC80/DAG1/ITGA6/FERMT1/NRP1/PTN/DOCK1/TRIOBP/FERMT2/P4HB/CDK6/MAP4K4/HSD17B12 13 GO:0035265 organ growth 17/982 178/18722 0.012491907524119 0.121046908080218 GJA1/SLC6A4/FGFR2/PARP2/YAP1/WWC1/TGFBR3/DUSP9/LATS2/TSKU/BASP1/WWC3/DUSP6/PSAP/FOXC1/VGLL4/RBPJ 17 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 11/982 97/18722 0.0126336870913353 0.121046908080218 ITGAV/ITGA6/YAP1/NRP1/CTTN/IFI6/LMNA/GSTP1/PSME3/GCLM/TCF7L2 11 GO:0003014 renal system process 12/982 110/18722 0.0126478281627382 0.121046908080218 GJA1/GJA5/ATP6V1B1/CLDN4/ADM/WFS1/COMT/CLN3/CYBA/LGMN/GSN/AKR1B1 12 GO:0031638 zymogen activation 8/982 60/18722 0.012666857550621 0.121046908080218 MMP14/ASPH/PRSS12/CTSL/PERP/DHCR24/LGMN/BAD 8 GO:0061951 establishment of protein localization to plasma membrane 8/982 60/18722 0.012666857550621 0.121046908080218 NSG1/CLN3/KRT18/RAB31/RILPL1/GORASP2/ANK3/LYPLA1 8 GO:0001707 mesoderm formation 9/982 72/18722 0.0126941446932284 0.121046908080218 ITGB4/GJA1/WLS/FGFR2/BMP7/ITGB1/EXT2/FOXC1/TXNRD1 9 GO:0030330 DNA damage response, signal transduction by p53 class mediator 9/982 72/18722 0.0126941446932284 0.121046908080218 SOX4/MDM2/TRIAP1/ATR/PLK2/BRCA2/GTSE1/PTTG1IP/KMT5A 9 GO:0043903 regulation of biological process involved in symbiotic interaction 9/982 72/18722 0.0126941446932284 0.121046908080218 ITGAV/TRIML2/DDB1/TRIM6/P4HB/TRIM28/GSN/TRIM27/EXOC2 9 GO:0070227 lymphocyte apoptotic process 9/982 72/18722 0.0126941446932284 0.121046908080218 GPAM/TNFRSF21/EFNA1/GLI3/SLC39A10/CCL5/IRS2/DFFA/BCL10 9 GO:1901880 negative regulation of protein depolymerization 9/982 72/18722 0.0126941446932284 0.121046908080218 SCIN/SWAP70/TRIOBP/HDAC6/CAMSAP2/EPS8/LIMA1/TPX2/GSN 9 GO:0003128 heart field specification 4/982 18/18722 0.0127587381731574 0.121219632625117 LRP2/ISL1/AXIN2/RBPJ 4 GO:1900006 positive regulation of dendrite development 4/982 18/18722 0.0127587381731574 0.121219632625117 COBL/BMP7/PTN/CYFIP1 4 GO:0000086 G2/M transition of mitotic cell cycle 14/982 137/18722 0.0128735072125943 0.121645314530601 PBX1/APP/SKP2/WEE1/BRD4/CENPF/MTA3/BRCC3/FOXO4/CCND1/TOPBP1/USP47/LCMT1/CCNA2 14 GO:0007266 Rho protein signal transduction 14/982 137/18722 0.0128735072125943 0.121645314530601 KANK1/NET1/MET/NRP1/GNA12/ADGRG1/CTNNAL1/ARHGEF11/HACD3/EPS8/EPS8L2/ITGB1/ARHGAP5/F11R 14 GO:0008203 cholesterol metabolic process 14/982 137/18722 0.0128735072125943 0.121645314530601 APP/LRP5/SQLE/TSKU/LDLR/DHCR24/NFE2L1/MVK/CEBPA/PPARD/ACADVL/RXRA/LIMA1/INSIG1 14 GO:0036363 transforming growth factor beta activation 3/982 10/18722 0.0130787372241306 0.121902354320124 ITGAV/LTBP1/ITGB8 3 GO:0042989 sequestering of actin monomers 3/982 10/18722 0.0130787372241306 0.121902354320124 SCIN/TMSB4X/GSN 3 GO:0048755 branching morphogenesis of a nerve 3/982 10/18722 0.0130787372241306 0.121902354320124 FGFR2/MAP3K13/RERE 3 GO:0140059 dendrite arborization 3/982 10/18722 0.0130787372241306 0.121902354320124 TPBG/NRP1/PTN 3 GO:1900246 positive regulation of RIG-I signaling pathway 3/982 10/18722 0.0130787372241306 0.121902354320124 PUM1/ZCCHC3/PUM2 3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 3/982 10/18722 0.0130787372241306 0.121902354320124 CYFIP1/NCKAP1/WASL 3 GO:0071333 cellular response to glucose stimulus 15/982 151/18722 0.0131052499917435 0.121902354320124 LRP1/LRP5/SOX4/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/BAD/NME1/ENY2 15 GO:0071456 cellular response to hypoxia 15/982 151/18722 0.0131052499917435 0.121902354320124 BMP7/EPAS1/PTN/MIEF1/SLC29A1/HILPDA/P4HB/PPARD/MDM2/PINK1/LMNA/MALAT1/BAD/CCNA2/RBPJ 15 GO:0060537 muscle tissue development 32/982 403/18722 0.013111046927452 0.121902354320124 LRP2/GJA1/NR2F2/OBSL1/FGFR2/GJA5/DSG2/BMP7/GPC1/DSP/ISL1/PARP2/YAP1/TGFBR3/CHD7/NF1/CENPF/CSRP2/TBX3/LMNA/FLNB/NUPR1/ITGB1/PKP2/BIN3/CBY1/SMAD5/FBXO22/FOXC1/KLF5/VGLL4/RBPJ 32 GO:0048193 Golgi vesicle transport 25/982 296/18722 0.013155025688412 0.122093619200635 PLPP3/PGAP1/KIF16B/CUX1/LMAN1/PRKCI/SCAMP1/RAB13/CLN3/TMED4/KRT18/COG4/CYTH3/RAB31/TFG/COPB2/ANK3/INSIG1/CREB3L2/LYPLA1/EHD3/TRIP11/TMED9/EXOC2/NAPA 25 GO:0060021 roof of mouth development 10/982 85/18722 0.0133399851702549 0.122457736564723 FRAS1/DLX6/TGFBR3/ITGB8/CHD7/DLX5/TFAP2A/GLI3/TBX3/INSIG1 10 GO:0019318 hexose metabolic process 21/982 237/18722 0.0133842983085701 0.122457736564723 SLC35B4/LRP5/GAA/SORBS1/SLC25A13/DDB1/FUT8/PHLDA2/PPP1R3E/SLC25A1/PPARD/C1QTNF1/MAN2B2/FUCA1/PMM2/RANBP2/IRS2/INPPL1/AKR1B1/BAD/LCMT1 21 GO:0038084 vascular endothelial growth factor signaling pathway 7/982 49/18722 0.013390183115544 0.122457736564723 SEMA6A/NRP2/NRP1/GAB1/FLT1/FOXC1/PGF 7 GO:0052372 modulation by symbiont of entry into host 7/982 49/18722 0.013390183115544 0.122457736564723 ITGAV/TRIML2/TRIM6/P4HB/GSN/TRIM27/EXOC2 7 GO:0060964 regulation of gene silencing by miRNA 7/982 49/18722 0.013390183115544 0.122457736564723 EGFR/KCNQ1OT1/LIN28B/PPARG/PUM1/PUM2/DHX9 7 GO:0070169 positive regulation of biomineral tissue development 7/982 49/18722 0.013390183115544 0.122457736564723 FBN2/BMP7/SLC4A2/PTN/ACVR2B/ATP2B1/TFAP2A 7 GO:0072091 regulation of stem cell proliferation 7/982 49/18722 0.013390183115544 0.122457736564723 GJA1/YAP1/FERMT1/FBLN1/FERMT2/TBX3/CCNE1 7 GO:0002478 antigen processing and presentation of exogenous peptide antigen 6/982 38/18722 0.0134290309269596 0.122457736564723 CTSV/B2M/CTSL/HLA-A/HLA-E/LGMN 6 GO:0042491 inner ear auditory receptor cell differentiation 6/982 38/18722 0.0134290309269596 0.122457736564723 MCOLN3/MYO7A/ESRP1/TRIOBP/TPRN/RBPJ 6 GO:0097242 amyloid-beta clearance 6/982 38/18722 0.0134290309269596 0.122457736564723 LRP2/LRP1/MME/IGF1R/LDLR/CLTC 6 GO:0050920 regulation of chemotaxis 20/982 223/18722 0.0137537062804748 0.125199532214584 SEMA6D/SEMA6A/MET/TPBG/NRP1/SWAP70/SEMA3F/SEMA4C/PTN/JAM3/TMSB4X/PTK2/CCL5/MPP1/LGMN/GSTP1/DPP4/CREB3/USP14/PGF 20 GO:0072088 nephron epithelium morphogenesis 9/982 73/18722 0.0138266495339506 0.125509334073767 LGR4/PBX1/IRX2/KIF26B/TACSTD2/LAMA5/MAGED1/GLI3/AHI1 9 GO:0043409 negative regulation of MAPK cascade 17/982 180/18722 0.013839685534995 0.125509334073767 DAG1/SEMA6A/BMP7/WNK2/FBLN1/PPARG/NF1/DUSP9/MARVELD3/IGF1R/EFNA1/TIMP3/PEBP1/PINK1/DUSP6/DUSP5/GSTP1 17 GO:0016125 sterol metabolic process 15/982 152/18722 0.0138599264621338 0.125509334073767 APP/LRP5/SQLE/TSKU/LDLR/CYB5R1/DHCR24/NFE2L1/MVK/CEBPA/PPARD/ACADVL/RXRA/LIMA1/INSIG1 15 GO:0043112 receptor metabolic process 16/982 166/18722 0.0139096105273534 0.12569764072746 LRP1/RNF43/TFRC/KIF16B/ZNRF3/ADM/ALS2/FUT8/NSG1/CLTC/LGMN/RAB31/ITGB1/AHI1/EHD3/ANXA2 16 GO:0030865 cortical cytoskeleton organization 8/982 61/18722 0.0139289180100597 0.12569764072746 RHOBTB3/NCKAP1/RAB13/RHOBTB1/FMNL2/RACGAP1/EPB41L3/RND3 8 GO:0001945 lymph vessel development 5/982 28/18722 0.0141100469240414 0.126457052845017 SVEP1/NR2F2/PTPN14/ACVR2B/FOXC1 5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 5/982 28/18722 0.0141100469240414 0.126457052845017 B2M/HLA-B/HLA-A/HLA-C/HLA-E 5 GO:0015740 C4-dicarboxylate transport 5/982 28/18722 0.0141100469240414 0.126457052845017 SLC25A13/SLC1A3/SLC13A3/SLC1A5/LRRC8D 5 GO:0032801 receptor catabolic process 5/982 28/18722 0.0141100469240414 0.126457052845017 RNF43/KIF16B/ZNRF3/LGMN/ANXA2 5 GO:0048640 negative regulation of developmental growth 12/982 112/18722 0.0144517985681225 0.129297738132636 GJA1/SEMA6D/SEMA6A/SLC6A4/ADRB1/NRP1/WWC1/SEMA3F/SEMA4C/WWC3/LGMN/VGLL4 12 GO:0010717 regulation of epithelial to mesenchymal transition 11/982 99/18722 0.0145766587202083 0.130191527199669 DAG1/BMP7/ISL1/GCNT2/DAB2/EFNA1/AXIN2/FERMT2/FOXC1/TCF7L2/ZNF750 11 GO:0071331 cellular response to hexose stimulus 15/982 153/18722 0.0146478790684328 0.130501678318093 LRP1/LRP5/SOX4/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/BAD/NME1/ENY2 15 GO:0031960 response to corticosteroid 16/982 167/18722 0.0146614232159514 0.130501678318093 EGFR/CTSV/ISL1/ALAD/ADM/AGL/SERPINF1/ATP2B1/CCND1/SPARC/CYBA/GSTP1/CDO1/BAD/ASS1/ANXA3 16 GO:0040013 negative regulation of locomotion 31/982 391/18722 0.0147354634530276 0.13093726979726 GJA1/DAG1/SEMA6D/CDH1/KANK1/NR2F2/SEMA6A/LRP1/CD200/TACSTD2/TCAF1/NRP1/GNA12/PTPRK/SEMA3F/FBLN1/PPARG/SEMA4C/PTN/NF1/DLG5/ADGRG1/SPINT2/CLDN19/MARVELD3/SERPINF1/WASL/PPARD/GSTP1/DPP4/CLIC4 31 GO:0006520 cellular amino acid metabolic process 24/982 284/18722 0.0148074270123068 0.131129947871294 GLDC/PLOD2/FN3K/PSAT1/SLC25A13/SLC1A3/GATB/GSS/COMT/CLN3/GSTZ1/GFPT1/RIMKLB/ASNSD1/SMS/AASDHPPT/PPAT/GCLM/TST/GCSH/CDO1/ENOSF1/ASS1/AZIN1 24 GO:0022409 positive regulation of cell-cell adhesion 24/982 284/18722 0.0148074270123068 0.131129947871294 PLPP3/KIF26B/BMP7/SOX4/TFRC/GCNT2/IL6ST/GPAM/B2M/CD46/HLA-A/TJP1/NFAT5/GLI3/YES1/CD24/HLA-E/CCL5/ANK3/DPP4/FLOT2/BAD/F11R/BCL10 24 GO:0060425 lung morphogenesis 7/982 50/18722 0.0148857606835228 0.131155621157525 DAG1/FGFR2/YAP1/NFIB/DLG5/RDH10/ESRP2 7 GO:0060688 regulation of morphogenesis of a branching structure 7/982 50/18722 0.0148857606835228 0.131155621157525 LGR4/FGFR2/TACSTD2/BMP7/MAGED1/PDGFA/MAP3K13 7 GO:0110151 positive regulation of biomineralization 7/982 50/18722 0.0148857606835228 0.131155621157525 FBN2/BMP7/SLC4A2/PTN/ACVR2B/ATP2B1/TFAP2A 7 GO:0046847 filopodium assembly 8/982 62/18722 0.0152801673616602 0.13395185371163 ITGB4/VSTM5/NRP1/PPP1R9A/WASL/FNBP1L/CLN3/RAB17 8 GO:0048002 antigen processing and presentation of peptide antigen 8/982 62/18722 0.0152801673616602 0.13395185371163 CTSV/B2M/CTSL/HLA-B/HLA-A/HLA-C/HLA-E/LGMN 8 GO:0060135 maternal process involved in female pregnancy 8/982 62/18722 0.0152801673616602 0.13395185371163 GJA1/NR2F2/CTSV/PTN/PPARD/PPAT/BSG/AKR1B1 8 GO:0007611 learning or memory 22/982 255/18722 0.0153550425308688 0.134382385639282 EGFR/SLC6A4/APP/TPBG/SHANK2/MME/EIF2AK4/PTN/NF1/B2M/PAK6/LDLR/SERPINF1/SYNJ1/COMT/CLN3/SLC11A2/FEN1/LGMN/UBA6/ITGB1/PLK2 22 GO:0071326 cellular response to monosaccharide stimulus 15/982 154/18722 0.0154700274900655 0.134551916755185 LRP1/LRP5/SOX4/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/BAD/NME1/ENY2 15 GO:0008356 asymmetric cell division 4/982 19/18722 0.0155033937825663 0.134551916755185 ETV5/TEAD3/ASPM/PARD3 4 GO:0015802 basic amino acid transport 4/982 19/18722 0.0155033937825663 0.134551916755185 SLC38A9/CLN3/SLC7A6/SLC7A2 4 GO:0035461 vitamin transmembrane transport 4/982 19/18722 0.0155033937825663 0.134551916755185 LRP2/SLC19A3/SLC19A1/FOLR1 4 GO:0035728 response to hepatocyte growth factor 4/982 19/18722 0.0155033937825663 0.134551916755185 NRP1/GAB1/LGMN/GCLM 4 GO:0044772 mitotic cell cycle phase transition 33/982 424/18722 0.0155889211694412 0.135069456511305 ADAMTS1/PBX1/EGFR/APP/SKP2/SOX4/WEE1/DDB1/BRD4/LATS2/CENPF/MTA3/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/EPS8/MDM2/TRIAP1/CDK6/ITGB1/PLK2/TOPBP1/PSME3/PPAT/GTSE1/USP47/CACUL1/CCNE1/LCMT1/CCNA2 33 GO:0009749 response to glucose 19/982 212/18722 0.01615863437757 0.139649884244473 GJA1/LRP1/LRP5/CTSV/SOX4/GPAM/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/TCF7L2/BAD/NME1/ENY2 19 GO:0008584 male gonad development 14/982 141/18722 0.0162408433479416 0.139649884244473 LRP2/CTSV/MMP14/ADGRG1/ASPM/TFAP2C/RHOBTB3/SPATA2/CCND1/RAB13/NUPR1/PRDX4/WDR48/RRM1 14 GO:0032355 response to estradiol 14/982 141/18722 0.0162408433479416 0.139649884244473 GJA1/NR2F2/EGFR/SLC6A4/BMP7/PTN/MMP15/CCND1/NCOA3/ESRRA/GSTP1/BAD/CCNA2/ASS1 14 GO:0043627 response to estrogen 9/982 75/18722 0.0163133088022621 0.139649884244473 PELP1/MMP14/GLI3/COMT/CCND1/CD24/MDM2/TRIM24/DTYMK 9 GO:1903364 positive regulation of cellular protein catabolic process 15/982 155/18722 0.0163272925593281 0.139649884244473 LRP2/LRP1/TMTC3/DAB2/LDLR/RNF128/PTK2/CEBPA/MDM2/MAGEF1/NUPR1/PLK2/PTTG1IP/FBXO22/VGLL4 15 GO:0021602 cranial nerve morphogenesis 5/982 29/18722 0.0163317541006764 0.139649884244473 NRP2/NRP1/SEMA3F/TFAP2A/GLI3 5 GO:0022011 myelination in peripheral nervous system 5/982 29/18722 0.0163317541006764 0.139649884244473 ITGB4/DAG1/NF1/PARD3/ADGRG6 5 GO:0032292 peripheral nervous system axon ensheathment 5/982 29/18722 0.0163317541006764 0.139649884244473 ITGB4/DAG1/NF1/PARD3/ADGRG6 5 GO:0021872 forebrain generation of neurons 7/982 51/18722 0.0164965364330968 0.140597931429793 NRP2/FGFR2/NRP1/ASPM/B2M/GLI3/METTL3 7 GO:0048013 ephrin receptor signaling pathway 7/982 51/18722 0.0164965364330968 0.140597931429793 RASA1/EFNA5/EFNA1/EPHB4/YES1/PTK2/RBPJ 7 GO:0098869 cellular oxidant detoxification 11/982 101/18722 0.0167365782125508 0.142411079864053 BMP7/MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5/TXNRD2/TXNRD1 11 GO:0009069 serine family amino acid metabolic process 6/982 40/18722 0.0170953127587467 0.142483894479772 GLDC/PSAT1/GCLM/TST/GCSH/CDO1 6 GO:0030501 positive regulation of bone mineralization 6/982 40/18722 0.0170953127587467 0.142483894479772 FBN2/BMP7/PTN/ACVR2B/ATP2B1/TFAP2A 6 GO:0045022 early endosome to late endosome transport 6/982 40/18722 0.0170953127587467 0.142483894479772 HOOK2/KIF16B/ANKRD27/HOOK1/DAB2/HOOK3 6 GO:0046546 development of primary male sexual characteristics 14/982 142/18722 0.0171793018081239 0.142483894479772 LRP2/CTSV/MMP14/ADGRG1/ASPM/TFAP2C/RHOBTB3/SPATA2/CCND1/RAB13/NUPR1/PRDX4/WDR48/RRM1 14 GO:0022411 cellular component disassembly 34/982 443/18722 0.0172214359890551 0.142483894479772 LAMC1/LRP1/CTSV/SCIN/SWAP70/MMP14/WIPI2/MICAL3/CTTN/IGF1R/TRIOBP/SYNJ1/MMP15/SLC25A4/CLN3/HDAC6/CAMSAP2/EPS8/PINK1/BLCAP/MAP4K4/UBA5/GABARAPL1/TOP2A/ABCE1/CST3/LIMA1/DPP4/TPX2/GSN/DFFA/NAPA/HUWE1/PHF23 34 GO:0001765 membrane raft assembly 3/982 11/18722 0.0172914695563066 0.142483894479772 PACSIN2/FLOT2/ANXA2 3 GO:0003093 regulation of glomerular filtration 3/982 11/18722 0.0172914695563066 0.142483894479772 GJA1/GJA5/CYBA 3 GO:0003174 mitral valve development 3/982 11/18722 0.0172914695563066 0.142483894479772 GJA5/SOX4/EFNA1 3 GO:0006183 GTP biosynthetic process 3/982 11/18722 0.0172914695563066 0.142483894479772 NME4/IMPDH2/NME1 3 GO:0006188 IMP biosynthetic process 3/982 11/18722 0.0172914695563066 0.142483894479772 ADSL/PPAT/ATIC 3 GO:0019048 modulation by virus of host process 3/982 11/18722 0.0172914695563066 0.142483894479772 DAG1/RXRA/RRAGA 3 GO:0021561 facial nerve development 3/982 11/18722 0.0172914695563066 0.142483894479772 NRP2/NRP1/SEMA3F 3 GO:0021604 cranial nerve structural organization 3/982 11/18722 0.0172914695563066 0.142483894479772 NRP2/NRP1/SEMA3F 3 GO:0021610 facial nerve morphogenesis 3/982 11/18722 0.0172914695563066 0.142483894479772 NRP2/NRP1/SEMA3F 3 GO:0033632 regulation of cell-cell adhesion mediated by integrin 3/982 11/18722 0.0172914695563066 0.142483894479772 SWAP70/CCL5/DPP4 3 GO:0046501 protoporphyrinogen IX metabolic process 3/982 11/18722 0.0172914695563066 0.142483894479772 ALAD/PPOX/ALAS1 3 GO:0048096 chromatin-mediated maintenance of transcription 3/982 11/18722 0.0172914695563066 0.142483894479772 SERTAD1/SERTAD2/CDCA4 3 GO:0048680 positive regulation of axon regeneration 3/982 11/18722 0.0172914695563066 0.142483894479772 LRP1/PTN/GRN 3 GO:0070778 L-aspartate transmembrane transport 3/982 11/18722 0.0172914695563066 0.142483894479772 SLC25A13/SLC1A3/SLC1A5 3 GO:0071679 commissural neuron axon guidance 3/982 11/18722 0.0172914695563066 0.142483894479772 DAG1/NRP1/NFIB 3 GO:0042471 ear morphogenesis 12/982 115/18722 0.0175158673105407 0.144105305822998 FGFR2/NAGLU/ATP6V1B1/DLX6/CHD7/MYO7A/TRIOBP/DLX5/TFAP2A/TPRN/FZD6/INSIG1 12 GO:0000082 G1/S transition of mitotic cell cycle 19/982 214/18722 0.017671077011276 0.144937364781114 ADAMTS1/EGFR/SKP2/SOX4/WEE1/BRD4/LATS2/CTDSPL/CCND1/MDM2/TRIAP1/CDK6/ITGB1/PLK2/PSME3/PPAT/GTSE1/CACUL1/CCNE1 19 GO:0009123 nucleoside monophosphate metabolic process 9/982 76/18722 0.0176725774541389 0.144937364781114 TK1/ADSL/TJP2/MPP1/PPAT/DTYMK/IMPDH2/ADK/ATIC 9 GO:0009896 positive regulation of catabolic process 37/982 492/18722 0.0178854891023842 0.146453235726901 LRP2/GJA1/LRP1/APP/KCNQ1OT1/SH3BP4/TRIML2/LIN28B/DDB1/TMTC3/DAB2/LDLR/TRIM6/RNF128/TFEB/SLC25A4/PTK2/MAP3K7/CEBPA/SH3D19/PUM1/TARDBP/YTHDF2/MDM2/MAGEF1/PINK1/PNPLA2/NUPR1/PLK2/METTL3/IRS2/PTTG1IP/FBXO22/TRIM27/BAD/VGLL4/HUWE1 37 GO:0007093 mitotic cell cycle checkpoint signaling 13/982 129/18722 0.0179659898433937 0.146837299370416 SOX4/CENPF/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/PLK2/TOPBP1/GTSE1/LCMT1 13 GO:0030833 regulation of actin filament polymerization 16/982 171/18722 0.0179886952257852 0.146837299370416 KANK1/KANK4/SCIN/RASA1/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/EPS8/GSN/RICTOR/TRIM27 16 GO:0060147 regulation of posttranscriptional gene silencing 7/982 52/18722 0.018226752241198 0.148177788427237 EGFR/KCNQ1OT1/LIN28B/PPARG/PUM1/PUM2/DHX9 7 GO:0030104 water homeostasis 8/982 64/18722 0.0182632865008577 0.148177788427237 MET/LSR/ATP6V1B1/CLDN4/WFS1/CLN3/EXT2/AKR1B1 8 GO:0032507 maintenance of protein location in cell 8/982 64/18722 0.0182632865008577 0.148177788427237 GJA1/SCIN/TMSB4X/PINK1/ANK3/INSIG1/GSN/GPAA1 8 GO:0032535 regulation of cellular component size 30/982 382/18722 0.0182665486884036 0.148177788427237 SEMA6D/KANK1/SEMA6A/LRP1/KANK4/SCIN/NRP1/RASA1/SWAP70/SEMA3F/SEMA4C/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/ALS2/TRIOBP/NCKAP1/WASL/KCNN4/CLN3/EPS8/DPYSL2/MAP3K13/LIMA1/VAV3/GSN/RICTOR/TRIM27 30 GO:0001701 in utero embryonic development 29/982 367/18722 0.0186270482578514 0.150492233663257 NR2F2/FGFR2/BMP7/ELF3/SPINT1/YAP1/EPAS1/CHD7/AMOT/SPINT2/RDH10/ADM/ALS2/FUT8/GLI3/TFEB/PHLDA2/CEBPA/ELL/MAFG/TBX3/SLC39A1/ITGB1/SLC39A3/BRCA2/TRIM28/FOXC1/KRT8/RBPJ 29 GO:0051271 negative regulation of cellular component movement 29/982 367/18722 0.0186270482578514 0.150492233663257 GJA1/DAG1/SEMA6D/CDH1/KANK1/NR2F2/LRP1/CD200/TACSTD2/TCAF1/GNA12/PTPRK/FBLN1/TGFBR3/PPARG/PTN/NF1/DLG5/ADGRG1/SPINT2/CLDN19/MARVELD3/SERPINF1/WASL/ACTN1/PPARD/GSTP1/DPP4/CLIC4 29 GO:1990748 cellular detoxification 12/982 116/18722 0.0186384169759325 0.150492233663257 BMP7/ABCG2/MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5/TXNRD2/TXNRD1 12 GO:0006099 tricarboxylic acid cycle 5/982 30/18722 0.0187742366682616 0.150656028402543 ACO1/IDH1/DHTKD1/SUCLA2/FH 5 GO:0045070 positive regulation of viral genome replication 5/982 30/18722 0.0187742366682616 0.150656028402543 DDB1/HACD3/CCL5/TOP2A/SRPK1 5 GO:0051125 regulation of actin nucleation 5/982 30/18722 0.0187742366682616 0.150656028402543 SCIN/CYFIP1/NCKAP1/WASL/GSN 5 GO:1902751 positive regulation of cell cycle G2/M phase transition 5/982 30/18722 0.0187742366682616 0.150656028402543 PBX1/APP/BRD4/MTA3/CCND1 5 GO:0001678 cellular glucose homeostasis 16/982 172/18722 0.0189045849756264 0.151468994213313 LRP1/LRP5/SOX4/EFNA5/SLC29A1/IGF1R/SERPINF1/PPARD/CYBA/MAP4K4/IRS2/GCLM/BAD/NME1/ENY2/LRRC8D 16 GO:0007492 endoderm development 9/982 77/18722 0.0191124849025358 0.152268505218776 LAMB1/LAMC1/ITGAV/COL4A2/ITGB5/MMP14/KIF16B/MMP15/DUSP5 9 GO:0048644 muscle organ morphogenesis 9/982 77/18722 0.0191124849025358 0.152268505218776 LRP2/FGFR2/DSP/ISL1/TGFBR3/CHD7/PKP2/FOXC1/RBPJ 9 GO:0014013 regulation of gliogenesis 11/982 103/18722 0.0191269963089639 0.152268505218776 LRP2/DAG1/EGFR/ETV5/SPINT1/IL6ST/PTN/NF1/LDLR/PRKCI/SYNJ1 11 GO:0090277 positive regulation of peptide hormone secretion 11/982 103/18722 0.0191269963089639 0.152268505218776 GJA1/EGFR/LRP1/ISL1/SOX4/TARDBP/PPARD/TM7SF3/IRS2/TCF7L2/BAD 11 GO:1902116 negative regulation of organelle assembly 6/982 41/18722 0.019163777409128 0.152268505218776 YAP1/LIMK2/PINK1/TRIM37/NUPR1/PHF23 6 GO:0014065 phosphatidylinositol 3-kinase signaling 14/982 144/18722 0.019179526059957 0.152268505218776 PLXNB1/EGFR/PIP5K1A/NF1/ERBB3/IGF1R/FLT1/PTK2/PPARD/CCL5/PDGFA/STAMBP/PIP5K1B/HCST 14 GO:0042475 odontogenesis of dentin-containing tooth 10/982 90/18722 0.0193324334437505 0.1530166507475 BMP7/CSF3R/LAMA5/DLX3/SLC4A2/ADM/PERP/GLI3/BSG/FOXC1 10 GO:0046849 bone remodeling 10/982 90/18722 0.0193324334437505 0.1530166507475 GJA1/LGR4/EGFR/LRP5/SYT7/TFRC/UBASH3B/PTN/NF1/P3H4 10 GO:0023061 signal release 35/982 463/18722 0.019446890405077 0.153686271776184 GJA1/EGFR/SLC6A4/WLS/LRP1/LRP5/KDM5B/ISL1/SYT7/SOX4/SLC16A1/CHD7/EFNA5/TRPV6/PPP1R9A/ADM/CAMK2G/FAM3B/SYNJ1/PTGES/SNX4/TARDBP/PPARD/C1QTNF1/TBX3/CCL5/PINK1/MAP4K4/TM7SF3/IRS2/DPP4/TCF7L2/BAD/ENY2/NAPA 35 GO:0014706 striated muscle tissue development 30/982 384/18722 0.0194759635053791 0.153686271776184 LRP2/GJA1/NR2F2/OBSL1/FGFR2/GJA5/DSG2/BMP7/GPC1/DSP/ISL1/PARP2/YAP1/TGFBR3/CHD7/CENPF/TBX3/LMNA/FLNB/NUPR1/ITGB1/PKP2/BIN3/CBY1/SMAD5/FBXO22/FOXC1/KLF5/VGLL4/RBPJ 30 GO:0006066 alcohol metabolic process 28/982 353/18722 0.0196126142624761 0.154530809657214 PLPP3/APP/LRP5/ACSS1/RDH10/DPAGT1/SQLE/TSKU/ISYNA1/LDLR/SYNJ1/NUDT4/RDH14/DHCR24/NFE2L1/MVK/CEBPA/P2RY6/PPARD/ACADVL/PNPLA2/IDH1/RXRA/LIMA1/INSIG1/AKR1B1/SLC5A3/SPTLC3 28 GO:0051099 positive regulation of binding 16/982 173/18722 0.019855727840367 0.156210371667201 MET/LRP1/APP/ISL1/NRP1/PPARG/B2M/TRIM6/PPP2CB/DHX9/PLK2/TRIM28/FOXC1/TCF7L2/ANXA2/NME1 16 GO:1902475 L-alpha-amino acid transmembrane transport 8/982 65/18722 0.0199015065532303 0.156334726177183 SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/SLC7A6/ITGB1/SLC7A2 8 GO:0010632 regulation of epithelial cell migration 24/982 292/18722 0.0200462245563934 0.157031362994044 PLPP3/NR2F2/MET/NRP2/TACSTD2/NRP1/PPARG/PTN/NF1/DOCK1/TMSB4X/MARVELD3/SERPINF1/EFNA1/PTK2/HDAC6/SPARC/LGMN/MAP4K4/GRN/PLK2/CAPN7/PDPK1/ANXA3 24 GO:0007566 embryo implantation 7/982 53/18722 0.0200805059656877 0.157031362994044 ITGB4/GJA1/PRLR/FBLN1/PPARD/TRIM28/BSG 7 GO:0060966 regulation of gene silencing by RNA 7/982 53/18722 0.0200805059656877 0.157031362994044 EGFR/KCNQ1OT1/LIN28B/PPARG/PUM1/PUM2/DHX9 7 GO:0046488 phosphatidylinositol metabolic process 15/982 159/18722 0.0201259194688817 0.15715089214025 PIP5K1A/SOCS6/PGAP2/PGAP1/TMEM150A/CDS1/PIGU/SOCS7/SYNJ1/CDIPT/PDGFA/PIGF/INPPL1/GPAA1/PIP5K1B 15 GO:0043524 negative regulation of neuron apoptotic process 14/982 145/18722 0.0202433814943926 0.157831805492902 LRP1/ISL1/NRP1/RASA1/ERBB3/WFS1/HRAS/PRKCI/CLN3/PINK1/LGMN/GRN/GCLM/PDPK1 14 GO:0032963 collagen metabolic process 11/982 104/18722 0.0204128157581606 0.158678460498608 SERPINH1/MMP14/CTSL/TRAM2/P3H4/MMP15/VIPAS39/PPARD/ITGB1/CST3/VIM 11 GO:0060419 heart growth 11/982 104/18722 0.0204128157581606 0.158678460498608 GJA1/FGFR2/PARP2/YAP1/TGFBR3/DUSP9/BASP1/DUSP6/FOXC1/VGLL4/RBPJ 11 GO:0006885 regulation of pH 10/982 91/18722 0.0207352603558089 0.160945116095088 ATP6V1B1/GPR89A/SLC4A2/RAB38/CLN3/MAFG/TM9SF4/ATP6V1H/GRN/CLIC4 10 GO:0045446 endothelial cell differentiation 12/982 118/18722 0.0210437491970946 0.163096873420573 NR2F2/MET/NRP1/PTN/ACVR2B/ID1/TJP1/TJP2/FSTL1/CLIC4/F11R/RBPJ 12 GO:0090316 positive regulation of intracellular protein transport 15/982 160/18722 0.0211725492730428 0.163609538694761 CDH1/TCAF1/TMEM30B/MIEF1/HRAS/GLI3/TARDBP/TM9SF4/MDM2/PINK1/ANK3/TRIM28/LEPROT/TCF7L2/HUWE1 15 GO:0021537 telencephalon development 21/982 248/18722 0.0211726301033289 0.163609538694761 LAMB1/LRP1/TACC2/NFIB/CHD7/NF1/ADGRG1/SLC2A1/ASPM/BTBD3/TSKU/GNG12/DLX5/GLI3/CDK6/UBA6/SLC38A2/BAD/NME1/ANXA3/ATIC 21 GO:0009124 nucleoside monophosphate biosynthetic process 6/982 42/18722 0.0213964511775364 0.164850648954254 TK1/ADSL/PPAT/IMPDH2/ADK/ATIC 6 GO:0051452 intracellular pH reduction 6/982 42/18722 0.0213964511775364 0.164850648954254 GPR89A/RAB38/CLN3/ATP6V1H/GRN/CLIC4 6 GO:0071480 cellular response to gamma radiation 5/982 31/18722 0.0214451805532292 0.164982391984725 YAP1/HRAS/MDM2/CYBA/ATR 5 GO:0051604 protein maturation 24/982 294/18722 0.0215588902936774 0.165612918662476 ENPEP/PISD/SERPINH1/SOX4/MME/MMP14/ASPH/PRSS12/CTSL/PERP/WFS1/GLI3/DHCR24/CLN3/MDM2/MAGEF1/LGMN/PRDX4/AFG3L2/GSN/GLG1/GCSH/BAD/BACE2 24 GO:0000041 transition metal ion transport 11/982 105/18722 0.0217612300159697 0.166581135981984 TFRC/SLC39A9/B2M/SLC39A11/SLC39A10/SLC40A1/SLC11A2/CLTC/SLC39A1/SLC39A3/SLC39A7 11 GO:0045862 positive regulation of proteolysis 29/982 372/18722 0.0218920214116343 0.166581135981984 APP/PCOLCE2/CLDN4/MMP14/FBLN1/PPARG/TMTC3/ASPH/PERP/DAB2/EFNA1/PTK2/CEBPA/SH3D19/MDM2/MAGEF1/PINK1/LGMN/NUPR1/BCL2L13/GRN/PLK2/PSME3/WDR48/GSN/FBXO22/BAD/NLRP2/BCL10 29 GO:0033762 response to glucagon 4/982 21/18722 0.0220361465060811 0.166581135981984 CYC1/CDO1/CCNA2/ASS1 4 GO:0051047 positive regulation of secretion 25/982 310/18722 0.022051465319493 0.166581135981984 GJA1/EGFR/MYH10/SLC6A4/WLS/LRP1/SCIN/ISL1/SYT7/SOX4/FRMD4A/PTGES/SNX4/KCNN4/EXPH5/TARDBP/PPARD/C1QTNF1/CYBA/PINK1/TM7SF3/IRS2/CD2AP/TCF7L2/BAD 25 GO:0001706 endoderm formation 7/982 54/18722 0.0220617365131528 0.166581135981984 LAMB1/ITGAV/COL4A2/ITGB5/MMP14/MMP15/DUSP5 7 GO:0002903 negative regulation of B cell apoptotic process 3/982 12/18722 0.0221709632994738 0.166581135981984 SLC39A10/IRS2/BCL10 3 GO:0006534 cysteine metabolic process 3/982 12/18722 0.0221709632994738 0.166581135981984 GCLM/TST/CDO1 3 GO:0009886 post-embryonic animal morphogenesis 3/982 12/18722 0.0221709632994738 0.166581135981984 FBN1/EFEMP1/MYO7A 3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 3/982 12/18722 0.0221709632994738 0.166581135981984 COL4A2/UBASH3B/COL4A1 3 GO:0070572 positive regulation of neuron projection regeneration 3/982 12/18722 0.0221709632994738 0.166581135981984 LRP1/PTN/GRN 3 GO:0071635 negative regulation of transforming growth factor beta production 3/982 12/18722 0.0221709632994738 0.166581135981984 TSKU/CD24/CD2AP 3 GO:0072520 seminiferous tubule development 3/982 12/18722 0.0221709632994738 0.166581135981984 ADGRG1/SPATA2/WDR48 3 GO:0072584 caveolin-mediated endocytosis 3/982 12/18722 0.0221709632994738 0.166581135981984 PROM2/CLN3/PACSIN2 3 GO:0090557 establishment of endothelial intestinal barrier 3/982 12/18722 0.0221709632994738 0.166581135981984 TJP1/TJP2/F11R 3 GO:2000628 regulation of miRNA metabolic process 3/982 12/18722 0.0221709632994738 0.166581135981984 KCNQ1OT1/LIN28B/HRAS 3 GO:0006029 proteoglycan metabolic process 9/982 79/18722 0.022243972689139 0.166581135981984 EXTL2/CHPF/GPC1/DSEL/GLCE/PPARD/XYLT1/EXT2/TCF7L2 9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 9/982 79/18722 0.022243972689139 0.166581135981984 PLXNB1/ERBB3/IGF1R/FLT1/PTK2/PPARD/CCL5/PDGFA/HCST 9 GO:0036294 cellular response to decreased oxygen levels 15/982 161/18722 0.0222597875344024 0.166581135981984 BMP7/EPAS1/PTN/MIEF1/SLC29A1/HILPDA/P4HB/PPARD/MDM2/PINK1/LMNA/MALAT1/BAD/CCNA2/RBPJ 15 GO:0046887 positive regulation of hormone secretion 13/982 133/18722 0.0225486463054068 0.168501058924072 GJA1/EGFR/LRP1/ISL1/SOX4/SNX4/TARDBP/PPARD/C1QTNF1/TM7SF3/IRS2/TCF7L2/BAD 13 GO:0045930 negative regulation of mitotic cell cycle 20/982 235/18722 0.0229393778648505 0.171175672307669 EGFR/BMP7/SOX4/WEE1/CENPF/CDKN1C/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/PLK2/TOPBP1/GTSE1/USP47/FOXC1/LCMT1 20 GO:0051258 protein polymerization 24/982 296/18722 0.0231589165827583 0.171941402578539 KANK1/MET/COBL/KANK4/SCIN/RASA1/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/TRIM6/NCKAP1/WASL/CAMSAP2/EPS8/MSRB2/PINK1/DIAPH3/TPX2/GSN/RICTOR/TRIM27 24 GO:0002793 positive regulation of peptide secretion 11/982 106/18722 0.0231738508459956 0.171941402578539 GJA1/EGFR/LRP1/ISL1/SOX4/TARDBP/PPARD/TM7SF3/IRS2/TCF7L2/BAD 11 GO:0030038 contractile actin filament bundle assembly 11/982 106/18722 0.0231738508459956 0.171941402578539 MET/TACSTD2/ITGB5/SORBS1/NRP1/PPP1R9A/TJP1/PDLIM1/FERMT2/PPFIA1/F11R 11 GO:0043149 stress fiber assembly 11/982 106/18722 0.0231738508459956 0.171941402578539 MET/TACSTD2/ITGB5/SORBS1/NRP1/PPP1R9A/TJP1/PDLIM1/FERMT2/PPFIA1/F11R 11 GO:0010517 regulation of phospholipase activity 8/982 67/18722 0.023486512294866 0.174013704730143 EGFR/LRP1/FGFR2/FLT1/HRAS/P2RY6/CCL5/PDPK1 8 GO:0048675 axon extension 12/982 120/18722 0.0236719315777763 0.174834589717716 SEMA6D/SEMA6A/LRP1/NRP2/NRP1/SEMA3F/SEMA4C/CYFIP1/CTTN/DPYSL2/MAP3K13/ITGB1 12 GO:0044839 cell cycle G2/M phase transition 14/982 148/18722 0.0237023307866715 0.174834589717716 PBX1/APP/SKP2/WEE1/BRD4/CENPF/MTA3/BRCC3/FOXO4/CCND1/TOPBP1/USP47/LCMT1/CCNA2 14 GO:0007589 body fluid secretion 10/982 93/18722 0.0237610799639313 0.174834589717716 EGFR/PRLR/SLC29A1/KCNN4/CCND1/CYBA/PPAT/CDO1/ANXA2/NME1 10 GO:0006284 base-excision repair 6/982 43/18722 0.0237984199960849 0.174834589717716 PARP2/APEX2/POLQ/FEN1/USP47/HUWE1 6 GO:0060443 mammary gland morphogenesis 6/982 43/18722 0.0237984199960849 0.174834589717716 LRP5/FGFR2/KDM5B/ELF3/GLI3/TBX3 6 GO:0098927 vesicle-mediated transport between endosomal compartments 6/982 43/18722 0.0237984199960849 0.174834589717716 HOOK2/KIF16B/ANKRD27/HOOK1/DAB2/HOOK3 6 GO:0071900 regulation of protein serine/threonine kinase activity 28/982 359/18722 0.0238448239676235 0.174929116476968 NR2F2/EGFR/LRP5/FZD10/BMP7/DVL3/PPARG/MAGED1/NF1/LRP6/LATS2/ALS2/FLT1/CDKN1C/HRAS/CCND1/MAP3K7/CD24/CEBPA/FERMT2/PDGFA/MAP3K13/SERTAD1/PKIB/GSTP1/RICTOR/CCNE1/CCNA2 28 GO:0007422 peripheral nervous system development 9/982 80/18722 0.0239402920372461 0.175136834875562 ITGB4/DAG1/GPC1/ISL1/NF1/ERBB3/PARD3/ADGRG6/SLC5A3 9 GO:0048145 regulation of fibroblast proliferation 9/982 80/18722 0.0239402920372461 0.175136834875562 PAWR/NF1/PDGFA/CDK6/NUPR1/GSTP1/DHX9/ANXA2/CCNA2 9 GO:1903532 positive regulation of secretion by cell 23/982 282/18722 0.0243037654176345 0.176658615261235 GJA1/EGFR/MYH10/SLC6A4/WLS/LRP1/ISL1/SYT7/SOX4/FRMD4A/PTGES/SNX4/KCNN4/EXPH5/TARDBP/PPARD/C1QTNF1/PINK1/TM7SF3/IRS2/CD2AP/TCF7L2/BAD 23 GO:0006506 GPI anchor biosynthetic process 5/982 32/18722 0.0243515230776127 0.176658615261235 PGAP2/PGAP1/PIGU/PIGF/GPAA1 5 GO:0014044 Schwann cell development 5/982 32/18722 0.0243515230776127 0.176658615261235 ITGB4/DAG1/NF1/PARD3/ADGRG6 5 GO:0035767 endothelial cell chemotaxis 5/982 32/18722 0.0243515230776127 0.176658615261235 MET/NRP1/TMSB4X/RAB13/LGMN 5 GO:0048841 regulation of axon extension involved in axon guidance 5/982 32/18722 0.0243515230776127 0.176658615261235 SEMA6D/SEMA6A/NRP1/SEMA3F/SEMA4C 5 GO:0060914 heart formation 5/982 32/18722 0.0243515230776127 0.176658615261235 LRP2/ISL1/FOLR1/AXIN2/RBPJ 5 GO:0042752 regulation of circadian rhythm 12/982 121/18722 0.0250729794097119 0.18138787878094 ADRB1/ZFHX3/PPARG/DDB1/MAGED1/GNA11/TARDBP/PHLPP1/PSPC1/TOP2A/NR2F6/OPN3 12 GO:0043244 regulation of protein-containing complex disassembly 12/982 121/18722 0.0250729794097119 0.18138787878094 SCIN/SWAP70/IGF1R/TRIOBP/CLN3/HDAC6/CAMSAP2/EPS8/LIMA1/TPX2/GSN/PHF23 12 GO:0010389 regulation of G2/M transition of mitotic cell cycle 10/982 94/18722 0.0253878681089388 0.182906180070275 PBX1/APP/BRD4/CENPF/MTA3/BRCC3/FOXO4/CCND1/TOPBP1/USP47 10 GO:0032922 circadian regulation of gene expression 8/982 68/18722 0.0254391048817683 0.182906180070275 LGR4/BHLHE41/ZFHX3/MAGED1/ID1/GFPT1/TOP1/HUWE1 8 GO:1904888 cranial skeletal system development 8/982 68/18722 0.0254391048817683 0.182906180070275 FGFR2/MMP14/RDH10/TFAP2A/GLI3/SLC39A1/SLC39A3/INSIG1 8 GO:0001894 tissue homeostasis 22/982 268/18722 0.0254830176027802 0.182906180070275 LAMC1/GJA1/EGFR/LSR/YAP1/TFRC/UBASH3B/GCNT2/EPAS1/NF1/SLC2A1/JAM3/B2M/TJP1/TJP2/NPHP3/PRDX1/ITGB1/AKR1B1/FH/FOXC1/F11R 22 GO:0001942 hair follicle development 9/982 81/18722 0.0257267161549316 0.182906180070275 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/FZD6/PDGFA/RBPJ 9 GO:0030641 regulation of cellular pH 9/982 81/18722 0.0257267161549316 0.182906180070275 GPR89A/SLC4A2/RAB38/CLN3/MAFG/TM9SF4/ATP6V1H/GRN/CLIC4 9 GO:0044773 mitotic DNA damage checkpoint signaling 9/982 81/18722 0.0257267161549316 0.182906180070275 SOX4/BRCC3/FOXO4/CCND1/MDM2/TRIAP1/PLK2/TOPBP1/GTSE1 9 GO:0048144 fibroblast proliferation 9/982 81/18722 0.0257267161549316 0.182906180070275 PAWR/NF1/PDGFA/CDK6/NUPR1/GSTP1/DHX9/ANXA2/CCNA2 9 GO:0060968 regulation of gene silencing 9/982 81/18722 0.0257267161549316 0.182906180070275 EGFR/KCNQ1OT1/LIN28B/PPARG/PUM1/PUM2/DHX9/TRIM28/DNMT1 9 GO:1901990 regulation of mitotic cell cycle phase transition 24/982 299/18722 0.0257295045149344 0.182906180070275 ADAMTS1/PBX1/EGFR/APP/SOX4/WEE1/DDB1/BRD4/CENPF/MTA3/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/PLK2/TOPBP1/PSME3/GTSE1/USP47/LCMT1 24 GO:1901215 negative regulation of neuron death 18/982 208/18722 0.0257964389225923 0.182906180070275 LRP1/CD200/ISL1/PARP2/NRP1/RASA1/ERBB3/WFS1/SERPINF1/HRAS/PRKCI/CLN3/PINK1/LGMN/NENF/GRN/GCLM/PDPK1 18 GO:0002053 positive regulation of mesenchymal cell proliferation 4/982 22/18722 0.0258439138634571 0.182906180070275 LRP5/FGFR2/PDGFA/IRS2 4 GO:0060343 trabecula formation 4/982 22/18722 0.0258439138634571 0.182906180070275 FBN2/ADAMTS1/TGFBR3/ADGRG6 4 GO:0099563 modification of synaptic structure 4/982 22/18722 0.0258439138634571 0.182906180070275 MYH10/SYNPO/CYFIP1/CLN3 4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 4/982 22/18722 0.0258439138634571 0.182906180070275 DLX5/CREB3/SMAD5/RBPJ 4 GO:2000114 regulation of establishment of cell polarity 4/982 22/18722 0.0258439138634571 0.182906180070275 KANK1/GSN/RICTOR/FLOT2 4 GO:0010498 proteasomal protein catabolic process 36/982 490/18722 0.026334714691666 0.184986004068636 SKP2/SOCS6/GNA12/DDB1/TMTC3/SIAH1/UGGT2/UBR3/ALAD/KLHL42/WFS1/ANKRD9/DAB2/CEBPA/PSMD1/TBL1X/MDM2/UBE4B/PINK1/NUPR1/PSMB5/PPP2CB/PLK2/PSME3/FEM1A/TMUB1/FBXW4/HSP90B1/CD2AP/FBXO22/RAD23B/USP14/FAF2/USP25/PSMD6/HUWE1 36 GO:1901991 negative regulation of mitotic cell cycle phase transition 16/982 179/18722 0.0263479125658003 0.184986004068636 SOX4/WEE1/CENPF/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/PLK2/TOPBP1/GTSE1/USP47/LCMT1 16 GO:0002066 columnar/cuboidal epithelial cell development 6/982 44/18722 0.0263744176993525 0.184986004068636 YAP1/IL6ST/CDK6/BAD/KLF5/PDPK1 6 GO:0007528 neuromuscular junction development 6/982 44/18722 0.0263744176993525 0.184986004068636 APP/PTN/ALS2/COL4A1/AFG3L2/ANK3 6 GO:0060711 labyrinthine layer development 6/982 44/18722 0.0263744176993525 0.184986004068636 FGFR2/BMP7/SPINT1/SPINT2/ADM/RBPJ 6 GO:0010518 positive regulation of phospholipase activity 7/982 56/18722 0.0264215055657849 0.184986004068636 EGFR/FGFR2/FLT1/HRAS/P2RY6/CCL5/PDPK1 7 GO:0030166 proteoglycan biosynthetic process 7/982 56/18722 0.0264215055657849 0.184986004068636 EXTL2/CHPF/DSEL/GLCE/XYLT1/EXT2/TCF7L2 7 GO:0051058 negative regulation of small GTPase mediated signal transduction 7/982 56/18722 0.0264215055657849 0.184986004068636 KANK1/MET/RASA1/ITGB1/PPP2CB/STAMBP/CD2AP 7 GO:0043624 cellular protein complex disassembly 13/982 136/18722 0.0265175621827271 0.185161451599872 SCIN/SWAP70/MICAL3/TRIOBP/SYNJ1/HDAC6/CAMSAP2/EPS8/ABCE1/LIMA1/TPX2/GSN/NAPA 13 GO:0098876 vesicle-mediated transport to the plasma membrane 13/982 136/18722 0.0265175621827271 0.185161451599872 ANKRD27/NSG1/SNX4/RAB13/CLN3/MICALL1/KRT18/RAB31/ANK3/RAB17/LYPLA1/EHD3/EXOC2 13 GO:0008593 regulation of Notch signaling pathway 10/982 95/18722 0.0270930315693182 0.188019996298933 BMP7/YAP1/MMP14/IL6ST/CD46/GALNT11/EPN2/PRKCI/YTHDF2/METTL3 10 GO:0030516 regulation of axon extension 10/982 95/18722 0.0270930315693182 0.188019996298933 SEMA6D/SEMA6A/LRP1/NRP1/SEMA3F/SEMA4C/CYFIP1/CTTN/DPYSL2/MAP3K13 10 GO:0032103 positive regulation of response to external stimulus 32/982 427/18722 0.0273658104581076 0.188019996298933 EGFR/MET/LRP1/APP/TPBG/CADM1/NRP1/SWAP70/IL6ST/PTN/TMSB4X/LDLR/TRIM6/SNX4/PTK2/TGM2/MAP3K7/CEBPA/PUM1/HLA-E/ZCCHC3/CCL5/CYBA/PSPC1/LGMN/NUPR1/PUM2/DHX9/GRN/FEM1A/CREB3/PGF 32 GO:0043254 regulation of protein-containing complex assembly 32/982 427/18722 0.0273658104581076 0.188019996298933 KANK1/MET/KANK4/SCIN/ISL1/TFRC/FERMT1/RASA1/ANKRD27/FER/JAM3/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/LMO4/MPP7/HDAC6/CAMSAP2/FERMT2/EPS8/PINK1/ATR/CAND1/GSN/RICTOR/TRIM27/LCMT1/NAPA 32 GO:0001881 receptor recycling 5/982 33/18722 0.0274994276948658 0.188019996298933 KIF16B/ALS2/NSG1/EHD3/ANXA2 5 GO:0006505 GPI anchor metabolic process 5/982 33/18722 0.0274994276948658 0.188019996298933 PGAP2/PGAP1/PIGU/PIGF/GPAA1 5 GO:0009156 ribonucleoside monophosphate biosynthetic process 5/982 33/18722 0.0274994276948658 0.188019996298933 ADSL/PPAT/IMPDH2/ADK/ATIC 5 GO:0060122 inner ear receptor cell stereocilium organization 5/982 33/18722 0.0274994276948658 0.188019996298933 MYO7A/TSKU/TRIOBP/TPRN/TRIP11 5 GO:0070570 regulation of neuron projection regeneration 5/982 33/18722 0.0274994276948658 0.188019996298933 LRP1/PTN/PTPRF/MAP4K4/GRN 5 GO:0071295 cellular response to vitamin 5/982 33/18722 0.0274994276948658 0.188019996298933 FOLR1/PTN/ATP2B1/MDM2/TRIM24 5 GO:2000036 regulation of stem cell population maintenance 5/982 33/18722 0.0274994276948658 0.188019996298933 BMP7/YAP1/PTN/NCOA3/WDR43 5 GO:1904377 positive regulation of protein localization to cell periphery 8/982 69/18722 0.0275021133093349 0.188019996298933 EGFR/LRP1/SORBS1/GNAI1/PRKCI/CLN3/ITGB1/PDPK1 8 GO:2001236 regulation of extrinsic apoptotic signaling pathway 14/982 151/18722 0.0275836557062252 0.188019996298933 ITGAV/ITGA6/YAP1/NRP1/CTTN/TIMP3/IFI6/LMNA/GSTP1/PSME3/GCLM/TCF7L2/ITM2C/BCL10 14 GO:1901342 regulation of vasculature development 27/982 348/18722 0.027684045523053 0.188019996298933 ADAMTS1/SEMA6A/COL4A2/ISL1/NRP1/PPARG/ITGB8/PTN/NF1/AMOT/GAB1/ADM/ID1/FLT1/SERPINF1/EPN2/EFNA1/TJP1/FOXO4/SPARC/ITGB1/GRN/PLK2/FOXC1/PGF/PDPK1/ANXA3 27 GO:0003334 keratinocyte development 3/982 13/18722 0.0277199726138573 0.188019996298933 EXPH5/IFT74/FLNB 3 GO:0015809 arginine transport 3/982 13/18722 0.0277199726138573 0.188019996298933 SLC38A9/CLN3/SLC7A2 3 GO:0016024 CDP-diacylglycerol biosynthetic process 3/982 13/18722 0.0277199726138573 0.188019996298933 GPAM/CDS1/AGPAT1 3 GO:0036302 atrioventricular canal development 3/982 13/18722 0.0277199726138573 0.188019996298933 CHD7/TBX3/RBPJ 3 GO:0060347 heart trabecula formation 3/982 13/18722 0.0277199726138573 0.188019996298933 ADAMTS1/TGFBR3/ADGRG6 3 GO:1900272 negative regulation of long-term synaptic potentiation 3/982 13/18722 0.0277199726138573 0.188019996298933 APP/PTN/PPP1R9A 3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 3/982 13/18722 0.0277199726138573 0.188019996298933 ZBTB7C/TMSB4X/ZNF593 3 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 3/982 13/18722 0.0277199726138573 0.188019996298933 HDAC6/PINK1/HUWE1 3 GO:0055123 digestive system development 13/982 137/18722 0.0279479873005636 0.189074840155304 LGR4/EGFR/WLS/FGFR2/COBL/YAP1/IL6ST/SLC4A2/GLI3/NPHP3/AHI1/KLF5/ASS1 13 GO:0090090 negative regulation of canonical Wnt signaling pathway 13/982 137/18722 0.0279479873005636 0.189074840155304 TPBG/ISL1/FERMT1/RBMS3/NOTUM/ZNRF3/LATS2/DAB2/GLI3/AXIN2/FZD6/NPHP3/TCF7L2 13 GO:0050891 multicellular organismal water homeostasis 7/982 57/18722 0.0288070053390053 0.194633859907062 MET/LSR/ATP6V1B1/CLDN4/WFS1/EXT2/AKR1B1 7 GO:0051092 positive regulation of NF-kappaB transcription factor activity 14/982 152/18722 0.028975918093307 0.195039619236513 APP/TRIML2/TFRC/FER/PRKCI/TRIM6/MAP3K7/MAP3K13/TRIM37/DHX9/FLOT2/RPS6KA4/TRIM27/BCL10 14 GO:0044843 cell cycle G1/S phase transition 20/982 241/18722 0.0290139525906281 0.195039619236513 ADAMTS1/EGFR/SKP2/SOX4/WEE1/BRD4/LATS2/CTDSPL/CCND1/MDM2/TRIAP1/CDK6/ITGB1/PLK2/PSME3/PPAT/GTSE1/CACUL1/CCNE1/CCNA2 20 GO:0003197 endocardial cushion development 6/982 45/18722 0.0291288081643488 0.195039619236513 BMP7/ISL1/CRELD1/TBX3/MDM2/RBPJ 6 GO:0030835 negative regulation of actin filament depolymerization 6/982 45/18722 0.0291288081643488 0.195039619236513 SCIN/SWAP70/TRIOBP/EPS8/LIMA1/GSN 6 GO:0035987 endodermal cell differentiation 6/982 45/18722 0.0291288081643488 0.195039619236513 LAMB1/ITGAV/COL4A2/ITGB5/MMP14/MMP15 6 GO:0060119 inner ear receptor cell development 6/982 45/18722 0.0291288081643488 0.195039619236513 NAGLU/MYO7A/TSKU/TRIOBP/TPRN/TRIP11 6 GO:0060421 positive regulation of heart growth 6/982 45/18722 0.0291288081643488 0.195039619236513 FGFR2/PARP2/YAP1/TGFBR3/BASP1/RBPJ 6 GO:0048678 response to axon injury 9/982 83/18722 0.0295786159994061 0.197797514170387 DAG1/LRP1/ISL1/NREP/FOLR1/PTN/JAM3/PTPRF/GRN 9 GO:0006869 lipid transport 30/982 398/18722 0.029810357190616 0.1989789316174 ITGAV/LRP1/SLC27A2/OSBPL10/KDM5B/SYT7/PPARG/SPNS1/PLEKHA8/SLC2A1/LRP6/TMEM30B/TSKU/LDLR/PTGES/PLA2G12A/KCNN4/CLN3/PPARD/C1QTNF1/TRIAP1/ATP10D/SLC25A17/RXRA/NME4/PSAP/LIMA1/IRS2/SCARB2/ANXA2 30 GO:0008202 steroid metabolic process 25/982 319/18722 0.0298780862866776 0.1989789316174 LRP2/PBX1/PRLR/APP/LRP5/SLC27A2/ADM/SQLE/TSKU/LDLR/CYB5R1/HSD17B1/COMT/DHCR24/NFE2L1/MVK/CEBPA/PPARD/ACADVL/LGMN/RXRA/LIMA1/INSIG1/AKR1B1/HSD17B12 25 GO:1901214 regulation of neuron death 25/982 319/18722 0.0298780862866776 0.1989789316174 LRP1/CD200/ISL1/PARP2/NRP1/RASA1/NF1/ERBB3/WFS1/SERPINF1/HRAS/PRKCI/TFAP2A/DHCR24/CLN3/CCL5/PINK1/LGMN/NUPR1/RILPL1/NENF/GRN/GCLM/BAD/PDPK1 25 GO:0010888 negative regulation of lipid storage 4/982 23/18722 0.0300223196286223 0.1989789316174 ITGAV/PPARG/PPARD/PNPLA2 4 GO:0036119 response to platelet-derived growth factor 4/982 23/18722 0.0300223196286223 0.1989789316174 FER/PTN/YES1/CCNA2 4 GO:0036303 lymph vessel morphogenesis 4/982 23/18722 0.0300223196286223 0.1989789316174 SVEP1/PTPN14/ACVR2B/FOXC1 4 GO:1900273 positive regulation of long-term synaptic potentiation 4/982 23/18722 0.0300223196286223 0.1989789316174 APP/MME/EIF2AK4/LGMN 4 GO:0010952 positive regulation of peptidase activity 17/982 197/18722 0.0303682455485569 0.200984287549113 APP/PCOLCE2/CLDN4/FBLN1/PPARG/ASPH/PERP/EFNA1/PINK1/LGMN/BCL2L13/GRN/PSME3/GSN/BAD/NLRP2/BCL10 17 GO:0045861 negative regulation of proteolysis 27/982 351/18722 0.0304019560729007 0.200984287549113 ITIH5/LRP1/APP/SPINT1/SERPINH1/APLP2/SPINT2/ALAD/SERPINF1/EFNA1/TIMP3/DHCR24/IFI6/CLN3/CRIM1/HDAC6/MDM2/TRIAP1/PEBP1/CST3/USP47/BIRC5/GLG1/PRDX5/USP14/ANXA2/USP25 27 GO:0090287 regulation of cellular response to growth factor stimulus 24/982 304/18722 0.0304941170308019 0.201338372699573 LRP2/FBN1/FBN2/SEMA6A/GPC1/LTBP1/NREP/FERMT1/RASL11B/TGFBR3/PPARG/FOLR1/PEG10/CYFIP1/LATS2/DAB2/CDKN1C/EPN2/CRIM1/ZNF451/FSTL1/GLG1/PDPK1/RBPJ 24 GO:0000096 sulfur amino acid metabolic process 5/982 34/18722 0.0308942656267602 0.203208687905651 COMT/SMS/GCLM/TST/CDO1 5 GO:0050931 pigment cell differentiation 5/982 34/18722 0.0308942656267602 0.203208687905651 ANKRD27/MREG/GNA11/GLI3/RAB38 5 GO:0086004 regulation of cardiac muscle cell contraction 5/982 34/18722 0.0308942656267602 0.203208687905651 GJA5/DSG2/DSP/DSC2/PKP2 5 GO:0016579 protein deubiquitination 13/982 139/18722 0.0309766605877791 0.203238064938184 USP43/BRCC3/SPATA2/USP27X/USP53/USP39/WDR48/USP47/STAMBP/USP14/UCHL3/ENY2/USP25 13 GO:0045598 regulation of fat cell differentiation 13/982 139/18722 0.0309766605877791 0.203238064938184 LRP5/BMP7/YAP1/PPARG/ADIRF/CDS1/ZBTB7C/CEBPA/HDAC6/FERMT2/PPARD/INSIG1/KLF5 13 GO:0016482 cytosolic transport 15/982 168/18722 0.0310820414574529 0.203673276686023 HOOK2/SYT7/KIF16B/ANKRD27/HOOK1/DAB2/RHOBTB3/EVI5/CLN3/HOOK3/TMEM87A/CLTC/DENND5A/EHD3/TRIM27 15 GO:2000027 regulation of animal organ morphogenesis 12/982 125/18722 0.0312873608246105 0.204296905089153 LGR4/TACSTD2/BMP7/DVL3/MAGED1/ZNRF3/SP6/DAB2/FZD6/PDGFA/NPHP3/AHI1 12 GO:0009161 ribonucleoside monophosphate metabolic process 7/982 58/18722 0.0313338811486431 0.204296905089153 ADSL/TJP2/MPP1/PPAT/IMPDH2/ADK/ATIC 7 GO:0042743 hydrogen peroxide metabolic process 7/982 58/18722 0.0313338811486431 0.204296905089153 EGFR/HDAC6/CYBA/PINK1/PRDX1/PRDX4/PRDX5 7 GO:2000736 regulation of stem cell differentiation 7/982 58/18722 0.0313338811486431 0.204296905089153 TACSTD2/YAP1/PTN/TRIM6/YTHDF2/METTL3/FOXC1 7 GO:0022404 molting cycle process 9/982 84/18722 0.0316482635633354 0.205489275003855 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/FZD6/PDGFA/RBPJ 9 GO:0022405 hair cycle process 9/982 84/18722 0.0316482635633354 0.205489275003855 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/FZD6/PDGFA/RBPJ 9 GO:0045445 myoblast differentiation 9/982 84/18722 0.0316482635633354 0.205489275003855 ISL1/EPAS1/MBNL3/PPARD/TBX3/DTYMK/FLOT2/TCF7L2/RBPJ 9 GO:0051651 maintenance of location in cell 18/982 213/18722 0.031674343769766 0.205489275003855 GJA1/MCOLN3/SCIN/GAA/UBASH3B/CHD7/ASPM/TMSB4X/ARHGAP21/P2RY6/CYBA/PINK1/ANK3/INSIG1/GSN/HSP90B1/GPAA1/PDPK1 18 GO:0016052 carbohydrate catabolic process 14/982 154/18722 0.0319139301822862 0.206786409727708 APP/LRP5/GAA/AGL/FUT8/NUPR1/MANBA/DHTKD1/SCARB2/RPE/ENOSF1/BAD/NEU1/GUSB 14 GO:0071230 cellular response to amino acid stimulus 8/982 71/18722 0.0319697233192559 0.20689091418516 SLC38A9/SH3BP4/CYBA/COL4A1/GCLM/DNMT1/RRAGA/ASS1 8 GO:0042398 cellular modified amino acid biosynthetic process 6/982 46/18722 0.0320655698939365 0.206997540305412 PLOD2/GSS/ALDH7A1/CKMT1B/GCLM/ATIC 6 GO:2000107 negative regulation of leukocyte apoptotic process 6/982 46/18722 0.0320655698939365 0.206997540305412 GPAM/EFNA1/SLC39A10/CCL5/IRS2/BCL10 6 GO:0034504 protein localization to nucleus 23/982 290/18722 0.0321459841056321 0.207260139796016 CDH1/BMP7/TRIM29/YAP1/TFRC/FERMT1/MAGED1/HEATR3/LATS2/TOR1AIP2/LIMK2/GLI3/TNPO1/TARDBP/FERMT2/RPF2/MDM2/LMNA/NUP153/RANBP2/PTTG1IP/TRIM28/CD2AP 23 GO:0045786 negative regulation of cell cycle 29/982 385/18722 0.0324941181761758 0.208749253695868 NR2F2/EGFR/BMP7/SOX4/PTPRK/WEE1/EIF2AK4/LATS2/CENPF/CDKN1C/CTDSPL/BRCC3/FOXO4/CCND1/CEBPA/ZWINT/SPDL1/MDM2/TRIAP1/CDK6/TRIM37/NUPR1/ATR/PLK2/TOPBP1/GTSE1/USP47/FOXC1/LCMT1 29 GO:0000075 cell cycle checkpoint signaling 15/982 169/18722 0.0325258024633744 0.208749253695868 SOX4/EIF2AK4/CENPF/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/GTSE1/LCMT1 15 GO:0009152 purine ribonucleotide biosynthetic process 15/982 169/18722 0.0325258024633744 0.208749253695868 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/SLC25A1/PINK1/SLC35B2/NME4/PPAT/IMPDH2/HSD17B12/ADK/NME1/ATIC 15 GO:0031333 negative regulation of protein-containing complex assembly 13/982 140/18722 0.032577049944102 0.208749253695868 KANK1/KANK4/SCIN/ISL1/ANKRD27/JAM3/TMSB4X/TRIOBP/LMO4/HDAC6/EPS8/GSN/LCMT1 13 GO:0050768 negative regulation of neurogenesis 13/982 140/18722 0.032577049944102 0.208749253695868 SEMA6D/SEMA6A/PRTG/BMP7/NRP1/SEMA3F/SEMA4C/PTN/NF1/B2M/ID1/LDLR/HOOK3 13 GO:0016049 cell growth 35/982 482/18722 0.0326730613624089 0.20899993735344 GJA1/SEMA6D/SEMA6A/NET1/EGFR/LRP1/APP/NRP2/COBL/SH3BP4/PARP2/NRP1/DCBLD2/MMP14/SEMA3F/SERTAD3/EIF2AK4/SEMA4C/CYFIP1/PAK6/CTTN/ARHGEF11/SMARCA2/CHPT1/HDAC6/DPYSL2/PPARD/CYBA/MAP3K13/ITGB1/SERTAD2/EPB41L3/BIN3/USP47/VGLL4 35 GO:0003333 amino acid transmembrane transport 10/982 98/18722 0.0326963092178695 0.20899993735344 SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/SLC7A6/ITGB1/SLC38A2/SLC7A2/LRRC8D 10 GO:0033157 regulation of intracellular protein transport 19/982 229/18722 0.0327737930770472 0.209238806229961 CDH1/TCAF1/PTPN14/FERMT1/LMAN1/TMEM30B/MIEF1/HRAS/GLI3/TARDBP/TM9SF4/MDM2/PINK1/ANK3/INSIG1/TRIM28/LEPROT/TCF7L2/HUWE1 19 GO:0035601 protein deacylation 11/982 112/18722 0.0330843953643441 0.210963577286575 ABHD12/NOTUM/MTA3/RCOR1/TBL1X/HDAC6/MORF4L2/BEX4/PINK1/SIN3B/LYPLA1 11 GO:0051091 positive regulation of DNA-binding transcription factor activity 21/982 260/18722 0.0332434564900325 0.211460815917085 PLPP3/CD200/APP/LRP5/TRIML2/TFRC/PPARG/FER/LRP6/PRKCI/TRIM6/MAP3K7/MAP3K13/PINK1/TRIM37/DHX9/FLOT2/RPS6KA4/TRIM27/ANXA3/BCL10 21 GO:0090150 establishment of protein localization to membrane 21/982 260/18722 0.0332434564900325 0.211460815917085 EGFR/TCAF1/MIEF1/TRAM2/HRAS/NSG1/PRKCI/PARD3/CD24/CLN3/MICALL1/KRT18/REEP1/RAB31/RILPL1/ZDHHC3/GORASP2/ANK3/LYPLA1/SEC63/SIL1 21 GO:0044774 mitotic DNA integrity checkpoint signaling 9/982 85/18722 0.033816349162516 0.212489266894491 SOX4/BRCC3/FOXO4/CCND1/MDM2/TRIAP1/PLK2/TOPBP1/GTSE1 9 GO:0098773 skin epidermis development 9/982 85/18722 0.033816349162516 0.212489266894491 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/FZD6/PDGFA/RBPJ 9 GO:0009071 serine family amino acid catabolic process 3/982 14/18722 0.0339347314653204 0.212489266894491 GLDC/GCSH/CDO1 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/982 14/18722 0.0339347314653204 0.212489266894491 GJA1/INSIG1/GPAA1 3 GO:0055057 neuroblast division 3/982 14/18722 0.0339347314653204 0.212489266894491 FGFR2/TEAD3/ASPM 3 GO:0060088 auditory receptor cell stereocilium organization 3/982 14/18722 0.0339347314653204 0.212489266894491 MYO7A/TRIOBP/TPRN 3 GO:0060576 intestinal epithelial cell development 3/982 14/18722 0.0339347314653204 0.212489266894491 YAP1/IL6ST/KLF5 3 GO:0060911 cardiac cell fate commitment 3/982 14/18722 0.0339347314653204 0.212489266894491 ISL1/TBX3/RBPJ 3 GO:0072160 nephron tubule epithelial cell differentiation 3/982 14/18722 0.0339347314653204 0.212489266894491 YAP1/CD24/MTSS1 3 GO:0072350 tricarboxylic acid metabolic process 3/982 14/18722 0.0339347314653204 0.212489266894491 ACO1/IDH1/ASS1 3 GO:0072531 pyrimidine-containing compound transmembrane transport 3/982 14/18722 0.0339347314653204 0.212489266894491 SLC19A3/SLC25A36/SLC29A1 3 GO:1902036 regulation of hematopoietic stem cell differentiation 3/982 14/18722 0.0339347314653204 0.212489266894491 YTHDF2/METTL3/FOXC1 3 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 3/982 14/18722 0.0339347314653204 0.212489266894491 HDAC6/PINK1/HUWE1 3 GO:0030042 actin filament depolymerization 7/982 59/18722 0.0340050854409536 0.212674491199058 SCIN/SWAP70/MICAL3/TRIOBP/EPS8/LIMA1/GSN 7 GO:0051896 regulation of protein kinase B signaling 16/982 185/18722 0.0343085347006022 0.213431097688177 LRP2/DAG1/EGFR/MET/TPBG/GCNT2/IGF1R/PTK2/FERMT2/PHLPP1/C1QTNF1/PDGFA/PINK1/ITGB1/RICTOR/TCF7L2 16 GO:0051057 positive regulation of small GTPase mediated signal transduction 8/982 72/18722 0.0343791706475093 0.213431097688177 NET1/ITGAV/ADGRG1/ALS2/HRAS/TGM2/MAP4K4/F11R 8 GO:0045454 cell redox homeostasis 5/982 35/18722 0.0345406039843524 0.213431097688177 PRDX1/PRDX4/PRDX5/TXNRD2/TXNRD1 5 GO:0070536 protein K63-linked deubiquitination 5/982 35/18722 0.0345406039843524 0.213431097688177 BRCC3/SPATA2/USP27X/STAMBP/USP25 5 GO:0001783 B cell apoptotic process 4/982 24/18722 0.034576165173794 0.213431097688177 TNFRSF21/SLC39A10/IRS2/BCL10 4 GO:0007035 vacuolar acidification 4/982 24/18722 0.034576165173794 0.213431097688177 CLN3/ATP6V1H/GRN/CLIC4 4 GO:0010288 response to lead ion 4/982 24/18722 0.034576165173794 0.213431097688177 APP/ALAD/SPARC/PPP2CB 4 GO:0016486 peptide hormone processing 4/982 24/18722 0.034576165173794 0.213431097688177 ENPEP/MME/CTSL/BACE2 4 GO:0036010 protein localization to endosome 4/982 24/18722 0.034576165173794 0.213431097688177 MGAT3/NRP1/MICALL1/PACSIN2 4 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 4/982 24/18722 0.034576165173794 0.213431097688177 PUM1/ZCCHC3/TSPAN6/PUM2 4 GO:1903077 negative regulation of protein localization to plasma membrane 4/982 24/18722 0.034576165173794 0.213431097688177 DAB2/CLTC/PPFIA1/LYPLA1 4 GO:0006909 phagocytosis 24/982 308/18722 0.0347651719033081 0.214170780499875 ITGAV/MET/COLEC12/LRP1/PIP5K1A/SYT7/MYO7A/DOCK1/ELMO3/LDLR/YES1/PTK2/TGM2/CLN3/RHOBTB1/TM9SF4/P2RY6/CYBA/RAB31/ITGB1/VAV3/GSN/IL2RG/ANXA3 24 GO:0048565 digestive tract development 12/982 127/18722 0.0347781156218163 0.214170780499875 LGR4/EGFR/FGFR2/COBL/YAP1/IL6ST/SLC4A2/GLI3/NPHP3/AHI1/KLF5/ASS1 12 GO:0007595 lactation 6/982 47/18722 0.0351882830150289 0.215172431660481 PRLR/SLC29A1/CCND1/PPAT/CDO1/NME1 6 GO:0019884 antigen processing and presentation of exogenous antigen 6/982 47/18722 0.0351882830150289 0.215172431660481 CTSV/B2M/CTSL/HLA-A/HLA-E/LGMN 6 GO:0035315 hair cell differentiation 6/982 47/18722 0.0351882830150289 0.215172431660481 MCOLN3/MYO7A/ESRP1/TRIOBP/TPRN/RBPJ 6 GO:0042311 vasodilation 6/982 47/18722 0.0351882830150289 0.215172431660481 GJA1/EGFR/ADRB1/GJA5/PPARD/EXT2 6 GO:0050885 neuromuscular process controlling balance 6/982 47/18722 0.0351882830150289 0.215172431660481 APP/IGDCC3/GAA/MYO7A/SLC1A3/CLN3 6 GO:0051489 regulation of filopodium assembly 6/982 47/18722 0.0351882830150289 0.215172431660481 NRP1/PPP1R9A/WASL/FNBP1L/CLN3/RAB17 6 GO:0032102 negative regulation of response to external stimulus 31/982 420/18722 0.0352402169990302 0.215237671975341 GJA1/SEMA6D/SEMA6A/CD200/ISL1/UBASH3B/NRP1/SEMA3F/PPARG/SEMA4C/CLDN19/HLA-B/HLA-A/LDLR/SERPINF1/YES1/MVK/HLA-E/PPARD/C1QTNF1/YTHDF2/PDGFA/TSPAN6/NENF/GSTP1/GRN/PLK2/METTL3/FEM1A/DPP4/ANXA2 31 GO:0045732 positive regulation of protein catabolic process 19/982 231/18722 0.0353506065661312 0.215659372922737 LRP2/GJA1/LRP1/DDB1/TMTC3/DAB2/LDLR/RNF128/PTK2/CEBPA/SH3D19/MDM2/MAGEF1/NUPR1/PLK2/PTTG1IP/FBXO22/VGLL4/HUWE1 19 GO:0010466 negative regulation of peptidase activity 21/982 262/18722 0.0356739680228111 0.217377823839933 ITIH5/LRP1/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/TIMP3/DHCR24/IFI6/CRIM1/MDM2/TRIAP1/PEBP1/CST3/USP47/BIRC5/PRDX5/USP14/ANXA2 21 GO:0071478 cellular response to radiation 16/982 186/18722 0.0357894938436119 0.217827304420396 NET1/YAP1/MME/PTPRK/EIF2AK4/DDB1/ADIRF/PTN/HRAS/MDM2/TRIAP1/CYBA/ATR/METTL3/USP47/OPN3 16 GO:0035023 regulation of Rho protein signal transduction 9/982 86/18722 0.0360847389122971 0.219368296231401 KANK1/NET1/MET/NRP1/ADGRG1/EPS8/EPS8L2/ITGB1/F11R 9 GO:0001952 regulation of cell-matrix adhesion 12/982 128/18722 0.0366235304899393 0.2223845576665 DAG1/LRP1/FERMT1/NRP1/RASA1/MMP14/NF1/EFNA5/PTK2/FERMT2/CDK6/MAP4K4 12 GO:0032271 regulation of protein polymerization 19/982 232/18722 0.0366936725609339 0.222443137244201 KANK1/MET/KANK4/SCIN/RASA1/FER/CYFIP1/PPP1R9A/CTTN/TMSB4X/TRIOBP/NCKAP1/WASL/CAMSAP2/EPS8/PINK1/GSN/RICTOR/TRIM27 19 GO:0007034 vacuolar transport 14/982 157/18722 0.0367184703158084 0.222443137244201 LRP1/HOOK2/HGSNAT/HOOK1/ALS2/VIPAS39/CLN3/HOOK3/PINK1/PSAP/GRN/SCARB2/LEPROT/EHD3 14 GO:0060038 cardiac muscle cell proliferation 7/982 60/18722 0.0368233419547711 0.222494061767771 GJA1/FGFR2/YAP1/TGFBR3/FOXC1/VGLL4/RBPJ 7 GO:0006664 glycolipid metabolic process 10/982 100/18722 0.0368548445872995 0.222494061767771 PGAP2/PGAP1/B3GNT5/ITGB8/PIGU/PIGF/FUCA1/GPAA1/ST3GAL6/NEU1 10 GO:0009062 fatty acid catabolic process 10/982 100/18722 0.0368548445872995 0.222494061767771 SLC27A2/ACADS/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/HADHB 10 GO:0051261 protein depolymerization 11/982 114/18722 0.0369693871143303 0.222927541258205 SCIN/SWAP70/MICAL3/TRIOBP/SYNJ1/HDAC6/CAMSAP2/EPS8/LIMA1/TPX2/GSN 11 GO:0009913 epidermal cell differentiation 17/982 202/18722 0.0372689154840536 0.224215297767963 MCOLN3/PIP5K1A/DSP/YAP1/MYO7A/ESRP1/TRIOBP/TPRN/EXPH5/MAFG/NCOA3/IFT74/FLNB/FOXC1/OPN3/CLIC4/RBPJ 17 GO:0016051 carbohydrate biosynthetic process 17/982 202/18722 0.0372689154840536 0.224215297767963 SLC35B4/SORBS1/SLC25A13/DDB1/AGL/FUT8/ISYNA1/B3GNT3/PPP1R3E/SLC25A1/P2RY6/CLTC/RANBP2/IRS2/EXT2/AKR1B1/ST3GAL6 17 GO:0045765 regulation of angiogenesis 26/982 342/18722 0.0374580394618023 0.225093472157559 ADAMTS1/SEMA6A/COL4A2/ISL1/NRP1/PPARG/ITGB8/PTN/NF1/AMOT/GAB1/ADM/FLT1/SERPINF1/EPN2/EFNA1/TJP1/FOXO4/SPARC/ITGB1/GRN/PLK2/FOXC1/PGF/PDPK1/ANXA3 26 GO:0062013 positive regulation of small molecule metabolic process 13/982 143/18722 0.0377347671460115 0.226495449290674 APP/SORBS1/PPARG/DDB1/RDH10/ADM/TMSB4X/COMT/PPP1R3E/P2RY6/PPARD/PINK1/IRS2 13 GO:0003203 endocardial cushion morphogenesis 5/982 36/18722 0.0384421999376433 0.229057431191874 BMP7/ISL1/TBX3/MDM2/RBPJ 5 GO:0003230 cardiac atrium development 5/982 36/18722 0.0384421999376433 0.229057431191874 GJA5/ISL1/SOX4/MDM2/NPHP3 5 GO:0010762 regulation of fibroblast migration 5/982 36/18722 0.0384421999376433 0.229057431191874 GNA12/FER/PTK2/CLN3/ITGB1 5 GO:1900182 positive regulation of protein localization to nucleus 9/982 87/18722 0.0384552025179825 0.229057431191874 CDH1/YAP1/TFRC/LIMK2/GLI3/TARDBP/FERMT2/TRIM28/CD2AP 9 GO:1901879 regulation of protein depolymerization 9/982 87/18722 0.0384552025179825 0.229057431191874 SCIN/SWAP70/TRIOBP/HDAC6/CAMSAP2/EPS8/LIMA1/TPX2/GSN 9 GO:2000177 regulation of neural precursor cell proliferation 9/982 87/18722 0.0384552025179825 0.229057431191874 LRP2/SLC6A4/SPINT1/PTN/NF1/ADGRG1/SPINT2/ASPM/GLI3 9 GO:0007517 muscle organ development 25/982 327/18722 0.0384690010974083 0.229057431191874 LRP2/DAG1/NR2F2/FGFR2/SGCE/GPC1/LAMA5/DSP/ISL1/ZFHX3/TGFBR3/CHD7/MRAS/CENPF/FOXO4/BASP1/FLNB/NUPR1/PKP2/BIN3/FBXO22/FOXC1/KLF5/ASS1/RBPJ 25 GO:0007498 mesoderm development 12/982 129/18722 0.0385371244024056 0.229201414917842 ITGB4/GJA1/WLS/FGFR2/BMP7/YAP1/MEST/TBX3/ITGB1/EXT2/FOXC1/TXNRD1 12 GO:2000146 negative regulation of cell motility 27/982 359/18722 0.0386455464291739 0.229584476280833 GJA1/DAG1/SEMA6D/CDH1/KANK1/NR2F2/LRP1/CD200/TACSTD2/TCAF1/GNA12/PTPRK/FBLN1/PPARG/PTN/NF1/DLG5/ADGRG1/SPINT2/CLDN19/MARVELD3/SERPINF1/WASL/PPARD/GSTP1/DPP4/CLIC4 27 GO:0000077 DNA damage checkpoint signaling 11/982 115/18722 0.0390269709397311 0.231552720860841 SOX4/EIF2AK4/BRCC3/FOXO4/CCND1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/GTSE1 11 GO:1903509 liposaccharide metabolic process 10/982 101/18722 0.0390656430900192 0.231552720860841 PGAP2/PGAP1/B3GNT5/ITGB8/PIGU/PIGF/FUCA1/GPAA1/ST3GAL6/NEU1 10 GO:0010996 response to auditory stimulus 4/982 25/18722 0.0395083438979015 0.232465178111583 ABHD12/PTN/SLC1A3/USP53 4 GO:0021846 cell proliferation in forebrain 4/982 25/18722 0.0395083438979015 0.232465178111583 FGFR2/GLI3/HOOK3/RRM1 4 GO:0032878 regulation of establishment or maintenance of cell polarity 4/982 25/18722 0.0395083438979015 0.232465178111583 KANK1/GSN/RICTOR/FLOT2 4 GO:0034389 lipid droplet organization 4/982 25/18722 0.0395083438979015 0.232465178111583 CDS1/SQLE/PNPLA2/FAF2 4 GO:0090330 regulation of platelet aggregation 4/982 25/18722 0.0395083438979015 0.232465178111583 UBASH3B/IL6ST/C1QTNF1/F11R 4 GO:0140448 signaling receptor ligand precursor processing 4/982 25/18722 0.0395083438979015 0.232465178111583 ENPEP/MME/CTSL/BACE2 4 GO:0007612 learning 13/982 144/18722 0.0395761269484443 0.232465178111583 APP/TPBG/SHANK2/EIF2AK4/PTN/NF1/PAK6/SYNJ1/COMT/CLN3/LGMN/UBA6/ITGB1 13 GO:0010821 regulation of mitochondrion organization 13/982 144/18722 0.0395761269484443 0.232465178111583 PISD/TFRC/PPARG/INF2/CTTN/MIEF1/SLC25A4/HDAC6/TRIAP1/PINK1/LMNA/BAD/HUWE1 13 GO:0006900 vesicle budding from membrane 7/982 61/18722 0.0397911376513078 0.23294116048173 PRKCI/WASL/FNBP1L/TFG/INSIG1/ANXA2/TMED9 7 GO:0030199 collagen fibril organization 7/982 61/18722 0.0397911376513078 0.23294116048173 COL14A1/SERPINH1/NF1/P3H4/VIPAS39/FOXC1/ANXA2 7 GO:0043954 cellular component maintenance 7/982 61/18722 0.0397911376513078 0.23294116048173 CTTN/IGF1R/TJP1/TPRN/FERMT2/KIFC3/MTSS1 7 GO:0006091 generation of precursor metabolites and energy 35/982 490/18722 0.0399685529283459 0.233717457482346 GLDC/APP/GAA/SORBS1/ACSS1/ACO1/SLC25A13/IL6ST/ASPH/AGL/DEGS1/ADSL/PHLDA2/SLC25A4/IL10RB/PPP1R3E/CEBPA/CYC1/PPARD/RPIA/GFPT1/ACADVL/CYBA/PINK1/IDH1/NUPR1/DHTKD1/COX6A1/IRS2/SUCLA2/AKR1B1/FH/RPE/OPN3/SURF1 35 GO:1901888 regulation of cell junction assembly 17/982 204/18722 0.040326358140173 0.235186028319384 GJA1/LRP1/APP/VSTM5/TPBG/NRP1/MMP14/DLG5/EFNA5/CLDN19/PPP1R9A/TJP1/PTK2/FERMT2/MAP4K4/RAB17/F11R 17 GO:0046578 regulation of Ras protein signal transduction 16/982 189/18722 0.0405108414278548 0.235186028319384 KANK1/NET1/MET/NRP1/RASA1/ADGRG1/ALS2/HRAS/EPS8/EPS8L2/MAP4K4/CYTH3/ITGB1/PPP2CB/STAMBP/F11R 16 GO:0006878 cellular copper ion homeostasis 3/982 15/18722 0.0408058580577152 0.235186028319384 APP/ANKRD9/SCO1 3 GO:0009263 deoxyribonucleotide biosynthetic process 3/982 15/18722 0.0408058580577152 0.235186028319384 DTYMK/ADK/RRM1 3 GO:0018146 keratan sulfate biosynthetic process 3/982 15/18722 0.0408058580577152 0.235186028319384 B3GNT3/B4GAT1/ST3GAL6 3 GO:0033599 regulation of mammary gland epithelial cell proliferation 3/982 15/18722 0.0408058580577152 0.235186028319384 KDM5B/CCND1/BRCA2 3 GO:0045176 apical protein localization 3/982 15/18722 0.0408058580577152 0.235186028319384 DLG5/JAM3/NAPA 3 GO:0045725 positive regulation of glycogen biosynthetic process 3/982 15/18722 0.0408058580577152 0.235186028319384 SORBS1/PPP1R3E/IRS2 3 GO:0048569 post-embryonic animal organ development 3/982 15/18722 0.0408058580577152 0.235186028319384 FBN1/EFEMP1/MYO7A 3 GO:0072044 collecting duct development 3/982 15/18722 0.0408058580577152 0.235186028319384 DLG5/DACT2/AKR1B1 3 GO:1902902 negative regulation of autophagosome assembly 3/982 15/18722 0.0408058580577152 0.235186028319384 PINK1/NUPR1/PHF23 3 GO:1990822 basic amino acid transmembrane transport 3/982 15/18722 0.0408058580577152 0.235186028319384 SLC38A9/SLC7A6/SLC7A2 3 GO:2001028 positive regulation of endothelial cell chemotaxis 3/982 15/18722 0.0408058580577152 0.235186028319384 MET/TMSB4X/LGMN 3 GO:1901657 glycosyl compound metabolic process 9/982 88/18722 0.0409294089783416 0.235637745288112 TK1/NME4/FUCA1/PPAT/DTYMK/AKR1B1/ADK/ATIC/GUSB 9 GO:0006720 isoprenoid metabolic process 11/982 116/18722 0.0411629146883196 0.236460091425413 LRP2/EGFR/LRP1/RDH10/DPAGT1/PDSS2/RDH14/MVK/PPARD/PNPLA2/AKR1B1 11 GO:0098732 macromolecule deacylation 11/982 116/18722 0.0411629146883196 0.236460091425413 ABHD12/NOTUM/MTA3/RCOR1/TBL1X/HDAC6/MORF4L2/BEX4/PINK1/SIN3B/LYPLA1 11 GO:1902749 regulation of cell cycle G2/M phase transition 10/982 102/18722 0.0413660242983699 0.237365437558083 PBX1/APP/BRD4/CENPF/MTA3/BRCC3/FOXO4/CCND1/TOPBP1/USP47 10 GO:0051961 negative regulation of nervous system development 13/982 145/18722 0.0414801094552828 0.237758517493137 SEMA6D/SEMA6A/PRTG/BMP7/NRP1/SEMA3F/SEMA4C/PTN/NF1/B2M/ID1/LDLR/HOOK3 13 GO:0060249 anatomical structure homeostasis 24/982 314/18722 0.0419919446808257 0.239183384621849 LAMC1/GJA1/EGFR/LSR/YAP1/TFRC/GAA/UBASH3B/GCNT2/EPAS1/NF1/SLC2A1/JAM3/B2M/ATP2B1/TJP1/TJP2/NPHP3/PRDX1/ITGB1/AKR1B1/FH/FOXC1/F11R 24 GO:0006778 porphyrin-containing compound metabolic process 6/982 49/18722 0.0420038305815977 0.239183384621849 ALAD/NFE2L1/SLC11A2/PPOX/SUCLA2/ALAS1 6 GO:0009066 aspartate family amino acid metabolic process 6/982 49/18722 0.0420038305815977 0.239183384621849 PLOD2/SLC25A13/ASNSD1/SMS/AASDHPPT/ASS1 6 GO:0010823 negative regulation of mitochondrion organization 6/982 49/18722 0.0420038305815977 0.239183384621849 TFRC/PPARG/TRIAP1/PINK1/LMNA/HUWE1 6 GO:0045778 positive regulation of ossification 6/982 49/18722 0.0420038305815977 0.239183384621849 FBN2/BMP7/PTN/ACVR2B/ATP2B1/TFAP2A 6 GO:0046580 negative regulation of Ras protein signal transduction 6/982 49/18722 0.0420038305815977 0.239183384621849 KANK1/MET/RASA1/ITGB1/PPP2CB/STAMBP 6 GO:0009755 hormone-mediated signaling pathway 16/982 190/18722 0.0421796733771085 0.239922765905123 LGR4/ESRRG/PRLR/SKP2/BMP7/LGR5/ISL1/YAP1/PPARG/LATS2/DAB2/HDAC6/ESRRA/PPARD/UBA5/RXRA 16 GO:0051453 regulation of intracellular pH 8/982 75/18722 0.0423361861652458 0.240550704834338 GPR89A/SLC4A2/RAB38/CLN3/TM9SF4/ATP6V1H/GRN/CLIC4 8 GO:0019827 stem cell population maintenance 12/982 131/18722 0.0425730805123157 0.241534820156525 LRP5/BMP7/SOX4/YAP1/PTN/ASPM/NCOA3/TBX3/HOOK3/METTL3/WDR43/RBPJ 12 GO:0034260 negative regulation of GTPase activity 5/982 37/18722 0.0426020004877306 0.241534820156525 FZD10/SH3BP4/AMOT/HRAS/F11R 5 GO:0032835 glomerulus development 7/982 62/18722 0.042910715688172 0.241970046518384 ENPEP/LGR4/BMP7/CD24/BASP1/MTSS1/FOXC1 7 GO:0046148 pigment biosynthetic process 7/982 62/18722 0.042910715688172 0.241970046518384 ALAD/NFE2L1/SLC11A2/PPOX/PPAT/ALAS1/OPN3 7 GO:0046824 positive regulation of nucleocytoplasmic transport 7/982 62/18722 0.042910715688172 0.241970046518384 CDH1/GLI3/TARDBP/MDM2/DHX9/TRIM28/TCF7L2 7 GO:0060675 ureteric bud morphogenesis 7/982 62/18722 0.042910715688172 0.241970046518384 LGR4/PBX1/KIF26B/TACSTD2/LAMA5/MAGED1/GLI3 7 GO:1903078 positive regulation of protein localization to plasma membrane 7/982 62/18722 0.042910715688172 0.241970046518384 EGFR/LRP1/SORBS1/PRKCI/CLN3/ITGB1/PDPK1 7 GO:0010951 negative regulation of endopeptidase activity 20/982 252/18722 0.043186078467132 0.24314631353583 ITIH5/APP/SPINT1/SERPINH1/APLP2/SPINT2/SERPINF1/TIMP3/DHCR24/IFI6/CRIM1/MDM2/TRIAP1/PEBP1/CST3/USP47/BIRC5/PRDX5/USP14/ANXA2 20 GO:0051346 negative regulation of hydrolase activity 28/982 379/18722 0.043212544602706 0.24314631353583 ITIH5/LRP1/APP/FZD10/SH3BP4/SPINT1/SERPINH1/APLP2/AMOT/SPINT2/SERPINF1/HRAS/TIMP3/DHCR24/IFI6/CRIM1/MDM2/TRIAP1/PEBP1/ABCE1/CST3/USP47/BIRC5/PRDX5/USP14/ANXA2/F11R/DFFA 28 GO:1903828 negative regulation of cellular protein localization 11/982 117/18722 0.0433783770816323 0.243816395320899 TRIM29/FERMT1/MAGED1/LMAN1/LATS2/DAB2/CLTC/PPFIA1/INSIG1/LEPROT/LYPLA1 11 GO:0010675 regulation of cellular carbohydrate metabolic process 13/982 146/18722 0.0434476050273236 0.243942634900452 SLC35B4/SORBS1/DDB1/PHLDA2/PPP1R3E/P2RY6/C1QTNF1/NUPR1/RANBP2/IRS2/SCARB2/BAD/LCMT1 13 GO:0019395 fatty acid oxidation 10/982 103/18722 0.0437573176305641 0.244890739013973 SLC27A2/ACADS/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/HADHB 10 GO:0030004 cellular monovalent inorganic cation homeostasis 10/982 103/18722 0.0437573176305641 0.244890739013973 GPR89A/SLC4A2/SLC1A3/RAB38/CLN3/MAFG/TM9SF4/ATP6V1H/GRN/CLIC4 10 GO:0050773 regulation of dendrite development 10/982 103/18722 0.0437573176305641 0.244890739013973 OBSL1/COBL/BMP7/ANKRD27/CUX1/PTN/CYFIP1/ID1/CAMSAP2/RAB17 10 GO:0010634 positive regulation of epithelial cell migration 15/982 176/18722 0.0440294869741947 0.246149843577063 PLPP3/MET/NRP2/NRP1/DOCK1/TMSB4X/HDAC6/SPARC/LGMN/MAP4K4/GRN/PLK2/CAPN7/PDPK1/ANXA3 15 GO:0006027 glycosaminoglycan catabolic process 4/982 26/18722 0.044819920063041 0.248967734876275 NAGLU/GNS/FUCA1/GUSB 4 GO:0048668 collateral sprouting 4/982 26/18722 0.044819920063041 0.248967734876275 LRP1/APP/COBL/HDAC6 4 GO:0051016 barbed-end actin filament capping 4/982 26/18722 0.044819920063041 0.248967734876275 SCIN/TRIOBP/EPS8/GSN 4 GO:0070102 interleukin-6-mediated signaling pathway 4/982 26/18722 0.044819920063041 0.248967734876275 YAP1/IL6ST/FER/CEBPA 4 GO:0097066 response to thyroid hormone 4/982 26/18722 0.044819920063041 0.248967734876275 CTSL/GCLM/AKR1B1/ANXA2 4 GO:1904376 negative regulation of protein localization to cell periphery 4/982 26/18722 0.044819920063041 0.248967734876275 DAB2/CLTC/PPFIA1/LYPLA1 4 GO:0014855 striated muscle cell proliferation 8/982 76/18722 0.0452377871900819 0.251021593599433 GJA1/FGFR2/YAP1/TGFBR3/PPARD/FOXC1/VGLL4/RBPJ 8 GO:0070231 T cell apoptotic process 6/982 50/18722 0.0457017492040624 0.253326592825069 GPAM/EFNA1/GLI3/CCL5/DFFA/BCL10 6 GO:0071453 cellular response to oxygen levels 15/982 177/18722 0.0458813884143713 0.254052358778515 BMP7/EPAS1/PTN/MIEF1/SLC29A1/HILPDA/P4HB/PPARD/MDM2/PINK1/LMNA/MALAT1/BAD/CCNA2/RBPJ 15 GO:0022617 extracellular matrix disassembly 7/982 63/18722 0.046184069433847 0.255186553142951 LAMC1/LRP1/CTSV/MMP14/MMP15/CST3/DPP4 7 GO:0072171 mesonephric tubule morphogenesis 7/982 63/18722 0.046184069433847 0.255186553142951 LGR4/PBX1/KIF26B/TACSTD2/LAMA5/MAGED1/GLI3 7 GO:1901031 regulation of response to reactive oxygen species 5/982 38/18722 0.0470221473908778 0.259542350043194 MET/BMP7/PAWR/HDAC6/PINK1 5 GO:0010212 response to ionizing radiation 13/982 148/18722 0.0475765285646475 0.26144480674171 NET1/YAP1/ALAD/HRAS/BRCC3/CCND1/MDM2/CYBA/ATR/TOPBP1/BRCA2/IKBIP/RRM1 13 GO:0006109 regulation of carbohydrate metabolic process 15/982 178/18722 0.0477874904881629 0.26144480674171 SLC35B4/APP/SORBS1/DDB1/PHLDA2/PPP1R3E/P2RY6/C1QTNF1/CLTC/NUPR1/RANBP2/IRS2/SCARB2/BAD/LCMT1 15 GO:2001234 negative regulation of apoptotic signaling pathway 18/982 224/18722 0.0480152919180431 0.26144480674171 ITGAV/ITGA6/YAP1/NRP1/CTTN/WFS1/IFI6/MDM2/TRIAP1/PINK1/LMNA/GSTP1/PSME3/USP47/PTTG1IP/CREB3/GCLM/TCF7L2 18 GO:0052548 regulation of endopeptidase activity 31/982 432/18722 0.0482964670558854 0.26144480674171 ITIH5/APP/SPINT1/SERPINH1/APLP2/PPARG/ASPH/SPINT2/PERP/SERPINF1/EFNA1/TIMP3/DHCR24/IFI6/CRIM1/MDM2/TRIAP1/PEBP1/LGMN/BCL2L13/CST3/PSME3/USP47/BIRC5/GSN/PRDX5/USP14/ANXA2/BAD/NLRP2/BCL10 31 GO:0001845 phagolysosome assembly 3/982 16/18722 0.048319170571129 0.26144480674171 SYT7/MYO7A/CLN3 3 GO:0001977 renal system process involved in regulation of blood volume 3/982 16/18722 0.048319170571129 0.26144480674171 GJA1/GJA5/CYBA 3 GO:0002093 auditory receptor cell morphogenesis 3/982 16/18722 0.048319170571129 0.26144480674171 MYO7A/TRIOBP/TPRN 3 GO:0010649 regulation of cell communication by electrical coupling 3/982 16/18722 0.048319170571129 0.26144480674171 GJA1/GJA5/ANK3 3 GO:0021535 cell migration in hindbrain 3/982 16/18722 0.048319170571129 0.26144480674171 SEMA4C/ITGB1/RERE 3 GO:0030540 female genitalia development 3/982 16/18722 0.048319170571129 0.26144480674171 LRP2/CHD7/TBX3 3 GO:0046037 GMP metabolic process 3/982 16/18722 0.048319170571129 0.26144480674171 TJP2/MPP1/IMPDH2 3 GO:0060572 morphogenesis of an epithelial bud 3/982 16/18722 0.048319170571129 0.26144480674171 FGFR2/BMP7/RDH10 3 GO:0061548 ganglion development 3/982 16/18722 0.048319170571129 0.26144480674171 NRP2/NRP1/SEMA3F 3 GO:0070242 thymocyte apoptotic process 3/982 16/18722 0.048319170571129 0.26144480674171 EFNA1/GLI3/DFFA 3 GO:0071391 cellular response to estrogen stimulus 3/982 16/18722 0.048319170571129 0.26144480674171 PELP1/MDM2/TRIM24 3 GO:0097284 hepatocyte apoptotic process 3/982 16/18722 0.048319170571129 0.26144480674171 KRT18/GSN/KRT8 3 GO:0099010 modification of postsynaptic structure 3/982 16/18722 0.048319170571129 0.26144480674171 MYH10/SYNPO/CYFIP1 3 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 3/982 16/18722 0.048319170571129 0.26144480674171 ZNRF3/DAB2/NPHP3 3 GO:2000232 regulation of rRNA processing 3/982 16/18722 0.048319170571129 0.26144480674171 YTHDF2/WDR43/HEATR1 3 GO:1902905 positive regulation of supramolecular fiber organization 17/982 209/18722 0.048754811740029 0.263528599001027 MET/APP/SCIN/NRP1/SWAP70/SYNPO/FER/CYFIP1/ID1/CTTN/NCKAP1/WASL/FERMT2/MTSS1/GSN/RICTOR/TRIM27 17 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 10/982 105/18722 0.0488175695145218 0.263594661063919 COBL/NRP1/CYFIP1/HRAS/NCKAP1/WASL/FNBP1L/EPS8/EPS8L2/CEP135 10 GO:0002065 columnar/cuboidal epithelial cell differentiation 9/982 91/18722 0.0489895826685411 0.264249910236929 FGFR2/SOX4/YAP1/DLX3/IL6ST/CDK6/BAD/KLF5/PDPK1 9 GO:0098727 maintenance of cell number 12/982 134/18722 0.0491637046622613 0.26491516892392 LRP5/BMP7/SOX4/YAP1/PTN/ASPM/NCOA3/TBX3/HOOK3/METTL3/WDR43/RBPJ 12 GO:0034976 response to endoplasmic reticulum stress 20/982 256/18722 0.0494143657426208 0.265962057625453 EIF2AK4/TMTC3/UGGT2/WFS1/CCND1/TARDBP/P4HB/UBE4B/TMEM33/UBA5/NUPR1/PPP2CB/GORASP2/CREB3L2/TMUB1/CREB3/HSP90B1/USP14/FAF2/USP25 20 GO:0045104 intermediate filament cytoskeleton organization 6/982 51/18722 0.0495957775735246 0.265962057625453 DST/DSP/FAM83H/KRT18/PKP2/VIM 6 GO:0060043 regulation of cardiac muscle cell proliferation 6/982 51/18722 0.0495957775735246 0.265962057625453 GJA1/FGFR2/YAP1/TGFBR3/VGLL4/RBPJ 6 GO:0030837 negative regulation of actin filament polymerization 7/982 64/18722 0.049612937513337 0.265962057625453 KANK1/KANK4/SCIN/TMSB4X/TRIOBP/EPS8/GSN 7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 7/982 64/18722 0.049612937513337 0.265962057625453 LRP1/LRP5/EFNA5/PPARD/MAP4K4/BAD/ENY2 7 GO:0016485 protein processing 18/982 225/18722 0.0497520640798977 0.266415685220448 ENPEP/PISD/MME/MMP14/ASPH/PRSS12/CTSL/PERP/GLI3/DHCR24/CLN3/MDM2/LGMN/AFG3L2/GSN/GLG1/BAD/BACE2 18 GO:0009150 purine ribonucleotide metabolic process 27/982 368/18722 0.0497997110985308 0.266415685220448 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC 27 GO:0009416 response to light stimulus 24/982 320/18722 0.050268815638857 0.267486026674137 EGFR/APP/SCARA3/MME/PTPRK/EIF2AK4/DDB1/PTN/NF1/SLC1A3/CDS1/GNA11/CCND1/FEN1/MDM2/UBE4B/TRIAP1/ITGB1/ATR/BRCA2/METTL3/NR2F6/USP47/OPN3 24 GO:0071496 cellular response to external stimulus 24/982 320/18722 0.050268815638857 0.267486026674137 GJA1/DAG1/EGFR/TMEM150C/SKP2/CTSV/EIF2AK4/FOLR1/PTN/SLC2A1/WIPI2/ATP2B1/TFEB/COMT/MDM2/TRIM24/CYBA/GABARAPL1/GSTP1/SLC38A2/BAD/RRAGA/F11R/BCL10 24 GO:0001958 endochondral ossification 4/982 27/18722 0.0505102169152916 0.267486026674137 MMP14/DLX5/INPPL1/FOXC1 4 GO:0003171 atrioventricular valve development 4/982 27/18722 0.0505102169152916 0.267486026674137 GJA5/SOX4/EFNA1/MDM2 4 GO:0003401 axis elongation 4/982 27/18722 0.0505102169152916 0.267486026674137 FGFR2/YAP1/RDH10/TRIM28 4 GO:0033688 regulation of osteoblast proliferation 4/982 27/18722 0.0505102169152916 0.267486026674137 PLXNB1/ITGAV/LRP5/FGFR2 4 GO:0034698 response to gonadotropin 4/982 27/18722 0.0505102169152916 0.267486026674137 CTSV/TGFBR3/GCLM/CCNA2 4 GO:0036075 replacement ossification 4/982 27/18722 0.0505102169152916 0.267486026674137 MMP14/DLX5/INPPL1/FOXC1 4 GO:1903205 regulation of hydrogen peroxide-induced cell death 4/982 27/18722 0.0505102169152916 0.267486026674137 MET/PAWR/HDAC6/PINK1 4 GO:0071901 negative regulation of protein serine/threonine kinase activity 11/982 120/18722 0.0505126028132716 0.267486026674137 NR2F2/LRP5/BMP7/PPARG/NF1/LRP6/LATS2/CDKN1C/CEBPA/PKIB/GSTP1 11 GO:0030705 cytoskeleton-dependent intracellular transport 16/982 195/18722 0.0512648453618532 0.270499493551053 DST/APP/HOOK2/MYO7A/MREG/HOOK1/ARHGAP21/WASL/FNBP1L/CLN3/HDAC6/ARMCX3/HOOK3/IFT74/FLOT2/KIF4A 16 GO:0034637 cellular carbohydrate biosynthetic process 8/982 78/18722 0.0514246733633769 0.270499493551053 SORBS1/AGL/ISYNA1/B3GNT3/PPP1R3E/IRS2/EXT2/AKR1B1 8 GO:0002062 chondrocyte differentiation 10/982 106/18722 0.05148879020916 0.270499493551053 SCIN/SERPINH1/EFEMP1/NFIB/TSKU/GLI3/AXIN2/CREB3L2/GLG1/TRIP11 10 GO:0046822 regulation of nucleocytoplasmic transport 10/982 106/18722 0.05148879020916 0.270499493551053 CDH1/PTPN14/FERMT1/GLI3/TARDBP/MDM2/DHX9/NUP153/TRIM28/TCF7L2 10 GO:0071887 leukocyte apoptotic process 10/982 106/18722 0.05148879020916 0.270499493551053 GPAM/TNFRSF21/CTSL/EFNA1/GLI3/SLC39A10/CCL5/IRS2/DFFA/BCL10 10 GO:0051495 positive regulation of cytoskeleton organization 18/982 226/18722 0.0515328715498732 0.270499493551053 MET/SCIN/NRP1/SWAP70/SYNPO/FER/CYFIP1/ID1/CTTN/HRAS/NCKAP1/WASL/FERMT2/KATNBL1/MTSS1/GSN/RICTOR/TRIM27 18 GO:0032386 regulation of intracellular transport 25/982 337/18722 0.0516412378802507 0.270499493551053 CDH1/TCAF1/PTPN14/FERMT1/WWC1/PGAP1/LMAN1/TMEM30B/MIEF1/DAB2/HRAS/GLI3/TARDBP/TM9SF4/MDM2/PINK1/DHX9/NUP153/ANK3/INSIG1/TRIM28/LEPROT/TCF7L2/ANXA2/HUWE1 25 GO:0062197 cellular response to chemical stress 25/982 337/18722 0.0516412378802507 0.270499493551053 NET1/EGFR/MET/MGAT3/BMP7/ETV5/PAWR/PTPRK/EPAS1/FER/SLC2A1/FUT8/PAGE4/NFE2L1/CLN3/HDAC6/P4HB/GPX8/MDM2/PINK1/PRDX1/AKR1B1/PRDX5/BAD/LRRC8D 25 GO:0046621 negative regulation of organ growth 5/982 39/18722 0.0517039867849693 0.270499493551053 GJA1/SLC6A4/WWC1/WWC3/VGLL4 5 GO:0086091 regulation of heart rate by cardiac conduction 5/982 39/18722 0.0517039867849693 0.270499493551053 DSG2/DSP/ISL1/DSC2/PKP2 5 GO:1903115 regulation of actin filament-based movement 5/982 39/18722 0.0517039867849693 0.270499493551053 GJA5/DSG2/DSP/DSC2/PKP2 5 GO:2000249 regulation of actin cytoskeleton reorganization 5/982 39/18722 0.0517039867849693 0.270499493551053 NRP1/HRAS/TJP1/CD2AP/F11R 5 GO:0050727 regulation of inflammatory response 28/982 386/18722 0.0521942374461789 0.272790723967204 EGFR/CD200/APP/ISL1/ABHD12/PPARG/IL6ST/BRD4/TMSB4X/LDLR/SERPINF1/PTGES/SNX4/SPATA2/YES1/MVK/TGM2/CEBPA/HLA-E/PPARD/CCL5/NUPR1/GSTP1/DHX9/GRN/PLK2/FEM1A/RICTOR 28 GO:0043491 protein kinase B signaling 17/982 211/18722 0.0524516483987421 0.273861659707547 LRP2/DAG1/EGFR/MET/TPBG/GCNT2/IGF1R/PTK2/FERMT2/PHLPP1/C1QTNF1/CCL5/PDGFA/PINK1/ITGB1/RICTOR/TCF7L2 17 GO:0038127 ERBB signaling pathway 11/982 121/18722 0.0530565651536276 0.276107331557851 EGFR/EFEMP1/KIF16B/FER/GAB1/PTK2/IFI6/BCAR3/LGMN/PDPK1/RBPJ 11 GO:0048706 embryonic skeletal system development 11/982 121/18722 0.0530565651536276 0.276107331557851 PBX1/FGFR2/BMP7/MMP14/KIAA1217/RDH10/TFAP2A/GLI3/XYLT1/SLC39A1/SLC39A3 11 GO:0002720 positive regulation of cytokine production involved in immune response 7/982 65/18722 0.0531987998705913 0.276107331557851 B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 7 GO:0048524 positive regulation of viral process 7/982 65/18722 0.0531987998705913 0.276107331557851 DDB1/HACD3/P4HB/CCL5/TOP2A/DHX9/SRPK1 7 GO:0006006 glucose metabolic process 16/982 196/18722 0.0532341328325586 0.276107331557851 SLC35B4/LRP5/GAA/SORBS1/SLC25A13/DDB1/PHLDA2/PPP1R3E/SLC25A1/PPARD/C1QTNF1/RANBP2/IRS2/INPPL1/BAD/LCMT1 16 GO:0045664 regulation of neuron differentiation 16/982 196/18722 0.0532341328325586 0.276107331557851 PBX1/SLC6A4/APP/BMP7/ETV5/ISL1/NREP/ZFHX3/EIF2AK4/ASPM/B2M/ESRP1/GLI3/DPYSL2/MAP3K13/TUG1 16 GO:0007389 pattern specification process 31/982 436/18722 0.0533545854259741 0.276107331557851 LRP2/NR2F2/PBX1/IRX2/WLS/LRP5/NRP2/BHLHE41/FGFR2/COBL/BMP7/ISL1/NRP1/SEMA3F/PGAP1/FOLR1/ADGRG1/ACVR2B/LRP6/GALNT11/GLI3/AXIN2/BASP1/TBX3/IFT74/NPHP3/AHI1/NEK8/SMAD5/FOXC1/RBPJ 31 GO:0046777 protein autophosphorylation 18/982 227/18722 0.053358165301057 0.276107331557851 EGFR/FGFR2/WNK2/EIF2AK4/FER/IGF1R/FLT1/EPHB4/YES1/PTK2/TRIM24/PDGFA/MAP3K13/PINK1/ATR/TRIM28/PDPK1/RAD50 18 GO:0098657 import into cell 18/982 227/18722 0.053358165301057 0.276107331557851 LRP2/SLC6A4/SLC27A2/SLC19A1/WNK2/FOLR1/SLC2A1/SLC1A3/TRPV6/SLC29A1/SLC43A2/SLC1A5/SLC39A10/SLC11A2/ITGB1/IRS2/SLC7A2/SLC5A3 18 GO:0045010 actin nucleation 6/982 52/18722 0.0536873895733933 0.276712869579861 SCIN/CYFIP1/NCKAP1/WASL/GSN/TRIM27 6 GO:0045103 intermediate filament-based process 6/982 52/18722 0.0536873895733933 0.276712869579861 DST/DSP/FAM83H/KRT18/PKP2/VIM 6 GO:0048260 positive regulation of receptor-mediated endocytosis 6/982 52/18722 0.0536873895733933 0.276712869579861 B2M/DAB2/SYNJ1/WASL/AHI1/ANXA2 6 GO:0072132 mesenchyme morphogenesis 6/982 52/18722 0.0536873895733933 0.276712869579861 BMP7/ISL1/TBX3/MDM2/FOXC1/RBPJ 6 GO:0005976 polysaccharide metabolic process 10/982 107/18722 0.0542554424965376 0.277770327795712 GAA/SORBS1/IL6ST/AGL/B3GNT3/PHLDA2/PPP1R3E/CLTC/IRS2/EXT2 10 GO:0021761 limbic system development 10/982 107/18722 0.0542554424965376 0.277770327795712 NRP2/FGFR2/NRP1/TSKU/GLI3/TBX3/CDK6/UBA6/NME1/ANXA3 10 GO:0032526 response to retinoic acid 10/982 107/18722 0.0542554424965376 0.277770327795712 GJA1/SLC6A4/FZD10/FGFR2/YAP1/SERPINF1/SYNJ1/PTGES/YES1/RXRA 10 GO:0042303 molting cycle 10/982 107/18722 0.0542554424965376 0.277770327795712 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/TSKU/FZD6/PDGFA/RBPJ 10 GO:0042633 hair cycle 10/982 107/18722 0.0542554424965376 0.277770327795712 LGR4/EGFR/FGFR2/LGR5/LAMA5/FERMT1/TSKU/FZD6/PDGFA/RBPJ 10 GO:0030902 hindbrain development 13/982 151/18722 0.0542665295870249 0.277770327795712 SLC6A4/WLS/BMP7/NAGLU/NFIB/SEMA4C/PTN/PDSS2/ITGB1/AHI1/RERE/FOXC1/ATIC 13 GO:0055067 monovalent inorganic cation homeostasis 13/982 151/18722 0.0542665295870249 0.277770327795712 ATP6V1B1/GPR89A/SLC4A2/SLC1A3/COMT/RAB38/CLN3/MAFG/TM9SF4/ATP6V1H/GRN/EXT2/CLIC4 13 GO:0006457 protein folding 17/982 212/18722 0.0543718375535702 0.277770327795712 MOGS/FKBP9/LMAN1/B2M/PPIC/WFS1/DNAJB4/HSPA4L/P4HB/PRDX4/GRN/DNAJC25/RANBP2/HSP90B1/SIL1/DFFA/BAG1 17 GO:0043523 regulation of neuron apoptotic process 17/982 212/18722 0.0543718375535702 0.277770327795712 LRP1/ISL1/NRP1/RASA1/NF1/ERBB3/WFS1/HRAS/PRKCI/TFAP2A/CLN3/PINK1/LGMN/NUPR1/GRN/GCLM/PDPK1 17 GO:0007568 aging 25/982 339/18722 0.0546247053077188 0.278789102627262 DAG1/COL4A2/LRP1/APP/CTSV/PAWR/MME/PPP1R9A/B2M/ADM/SERPINF1/HRAS/ATP2B1/GSS/FOXO4/TBX3/CDK6/LMNA/ATR/PLK2/RPN2/BRCA2/GCLM/SEC63/ASS1 25 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 8/982 79/18722 0.0547126396365305 0.27896493484276 OBSL1/NRP1/ANKRD27/CUX1/DOCK1/TRIOBP/FERMT2/P4HB 8 GO:2001233 regulation of apoptotic signaling pathway 26/982 356/18722 0.055838637040974 0.281406096491643 ITGAV/ITGA6/YAP1/NRP1/MAGED1/SIAH1/CTTN/WFS1/TIMP3/IFI6/P4HB/MDM2/TRIAP1/PINK1/LMNA/NUPR1/GSTP1/PSME3/USP47/PTTG1IP/CREB3/GCLM/TCF7L2/BAD/ITM2C/BCL10 26 GO:0009260 ribonucleotide biosynthetic process 15/982 182/18722 0.0559662199146019 0.281406096491643 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/SLC25A1/PINK1/SLC35B2/NME4/PPAT/IMPDH2/HSD17B12/ADK/NME1/ATIC 15 GO:0007254 JNK cascade 14/982 167/18722 0.0564490317073259 0.281406096491643 EGFR/APP/DUSP9/TRAF4/MARVELD3/IGF1R/HRAS/HACD3/MAP3K7/PHLPP1/MAP3K13/PINK1/MAP4K4/GSTP1 14 GO:0006744 ubiquinone biosynthetic process 3/982 17/18722 0.0564564216242845 0.281406096491643 PDSS2/COQ5/COQ6 3 GO:0010715 regulation of extracellular matrix disassembly 3/982 17/18722 0.0564564216242845 0.281406096491643 LRP1/CST3/DPP4 3 GO:0015867 ATP transport 3/982 17/18722 0.0564564216242845 0.281406096491643 GJA1/SLC25A4/SLC25A17 3 GO:0030903 notochord development 3/982 17/18722 0.0564564216242845 0.281406096491643 COBL/YAP1/EFNA1 3 GO:0033623 regulation of integrin activation 3/982 17/18722 0.0564564216242845 0.281406096491643 FERMT1/JAM3/FERMT2 3 GO:0035729 cellular response to hepatocyte growth factor stimulus 3/982 17/18722 0.0564564216242845 0.281406096491643 NRP1/LGMN/GCLM 3 GO:0038065 collagen-activated signaling pathway 3/982 17/18722 0.0564564216242845 0.281406096491643 COL4A2/UBASH3B/COL4A1 3 GO:0044539 long-chain fatty acid import into cell 3/982 17/18722 0.0564564216242845 0.281406096491643 SLC27A2/SLC2A1/IRS2 3 GO:0045815 positive regulation of gene expression, epigenetic 3/982 17/18722 0.0564564216242845 0.281406096491643 SERTAD1/SERTAD2/CDCA4 3 GO:0060033 anatomical structure regression 3/982 17/18722 0.0564564216242845 0.281406096491643 LRP5/FLT1/SMAD5 3 GO:0060977 coronary vasculature morphogenesis 3/982 17/18722 0.0564564216242845 0.281406096491643 LRP2/NRP1/TGFBR3 3 GO:0070875 positive regulation of glycogen metabolic process 3/982 17/18722 0.0564564216242845 0.281406096491643 SORBS1/PPP1R3E/IRS2 3 GO:0090136 epithelial cell-cell adhesion 3/982 17/18722 0.0564564216242845 0.281406096491643 DSP/ITGB5/KIFC3 3 GO:0140354 lipid import into cell 3/982 17/18722 0.0564564216242845 0.281406096491643 SLC27A2/SLC2A1/IRS2 3 GO:1901663 quinone biosynthetic process 3/982 17/18722 0.0564564216242845 0.281406096491643 PDSS2/COQ5/COQ6 3 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 3/982 17/18722 0.0564564216242845 0.281406096491643 NFIB/PPARG/PPARD 3 GO:1903358 regulation of Golgi organization 3/982 17/18722 0.0564564216242845 0.281406096491643 CAMSAP2/PDE4DIP/EHD3 3 GO:0000423 mitophagy 4/982 28/18722 0.0565769119138333 0.281406096491643 SLC25A4/HDAC6/PINK1/HUWE1 4 GO:0006516 glycoprotein catabolic process 4/982 28/18722 0.0565769119138333 0.281406096491643 GPC1/CTSL/MANBA/CST3 4 GO:0010543 regulation of platelet activation 5/982 40/18722 0.0566480830744296 0.281406096491643 UBASH3B/IL6ST/C1QTNF1/PDGFA/F11R 5 GO:0030866 cortical actin cytoskeleton organization 5/982 40/18722 0.0566480830744296 0.281406096491643 NCKAP1/RAB13/FMNL2/RACGAP1/EPB41L3 5 GO:0043001 Golgi to plasma membrane protein transport 5/982 40/18722 0.0566480830744296 0.281406096491643 CLN3/KRT18/RAB31/ANK3/LYPLA1 5 GO:0044275 cellular carbohydrate catabolic process 5/982 40/18722 0.0566480830744296 0.281406096491643 GAA/AGL/SCARB2/ENOSF1/GUSB 5 GO:0060412 ventricular septum morphogenesis 5/982 40/18722 0.0566480830744296 0.281406096491643 FGFR2/SOX4/TGFBR3/TBX3/RBPJ 5 GO:0010038 response to metal ion 27/982 373/18722 0.0569261959381925 0.281796997254519 CDH1/EGFR/APP/SYT7/ACO1/SLC25A13/TRPV6/B2M/ALAD/SERPINF1/GSS/TFAP2A/HSD17B1/PTGES/CCND1/CEBPA/SLC11A2/SPARC/MDM2/LGMN/PPP2CB/ANK3/DTYMK/BSG/CLIC4/BAD/ASS1 27 GO:0050922 negative regulation of chemotaxis 7/982 66/18722 0.0569428748286548 0.281796997254519 SEMA6D/SEMA6A/NRP1/SEMA3F/SEMA4C/GSTP1/DPP4 7 GO:0051893 regulation of focal adhesion assembly 7/982 66/18722 0.0569428748286548 0.281796997254519 LRP1/NRP1/MMP14/EFNA5/PTK2/FERMT2/MAP4K4 7 GO:0090109 regulation of cell-substrate junction assembly 7/982 66/18722 0.0569428748286548 0.281796997254519 LRP1/NRP1/MMP14/EFNA5/PTK2/FERMT2/MAP4K4 7 GO:0034440 lipid oxidation 10/982 108/18722 0.0571184446589169 0.282256421993736 SLC27A2/ACADS/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/HADHB 10 GO:0045444 fat cell differentiation 18/982 229/18722 0.0571439381950507 0.282256421993736 ADRB1/LRP5/BMP7/YAP1/PPARG/ADIRF/CDS1/ZBTB7C/ARL4A/CCND1/CEBPA/HDAC6/FERMT2/PPARD/INSIG1/CBY1/TCF7L2/KLF5 18 GO:0016925 protein sumoylation 6/982 53/18722 0.0579776300339514 0.285566520643678 CBX4/MDM2/ZNF451/RANBP2/TRIM28/TRIM27 6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 9/982 94/18722 0.0580330735970664 0.285566520643678 NR2F2/EGFR/LATS2/CDKN1C/CCND1/CEBPA/SERTAD1/CCNE1/CCNA2 9 GO:0001738 morphogenesis of a polarized epithelium 9/982 94/18722 0.0580330735970664 0.285566520643678 LAMA5/DVL3/DLG5/FAT1/ZNRF3/DAB2/FZD6/NPHP3/AHI1 9 GO:1990830 cellular response to leukemia inhibitory factor 9/982 94/18722 0.0580330735970664 0.285566520643678 NRP2/PCOLCE2/KDM5B/TFRC/MRAS/EPS8/MRPL15/GCLM/KLF5 9 GO:0071229 cellular response to acid chemical 8/982 80/18722 0.0581317893697843 0.285782670455037 SLC38A9/SH3BP4/CYBA/COL4A1/GCLM/DNMT1/RRAGA/ASS1 8 GO:0044242 cellular lipid catabolic process 17/982 214/18722 0.0583580732327637 0.286284618911791 LRP1/SLC27A2/ABHD12/LDLR/ACADS/ECI1/PPARD/ACADVL/PNPLA2/IDH1/SLC25A17/FUCA1/DECR2/ECHDC2/IRS2/HADHB/NEU1 17 GO:0031570 DNA integrity checkpoint signaling 11/982 123/18722 0.0583985495632947 0.286284618911791 SOX4/EIF2AK4/BRCC3/FOXO4/CCND1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/GTSE1 11 GO:0071482 cellular response to light stimulus 11/982 123/18722 0.0583985495632947 0.286284618911791 MME/PTPRK/EIF2AK4/DDB1/PTN/MDM2/TRIAP1/ATR/METTL3/USP47/OPN3 11 GO:0046486 glycerolipid metabolic process 28/982 392/18722 0.0609110303515326 0.298321065083187 PISD/PIP5K1A/OSBPL10/SOCS6/PGAP2/PGAP1/ABHD12/GPAM/TMEM150A/CDS1/PIGU/SOCS7/AGPAT1/LDLR/SYNJ1/CDIPT/RAB38/CLN3/CHPT1/SLC44A1/PDGFA/PNPLA2/PIGF/SERINC2/INSIG1/INPPL1/GPAA1/PIP5K1B 28 GO:1990823 response to leukemia inhibitory factor 9/982 95/18722 0.0612709849720635 0.29980249307156 NRP2/PCOLCE2/KDM5B/TFRC/MRAS/EPS8/MRPL15/GCLM/KLF5 9 GO:1903533 regulation of protein targeting 8/982 81/18722 0.0616830302700421 0.301243415788338 TCAF1/LMAN1/MIEF1/HRAS/PINK1/ANK3/LEPROT/HUWE1 8 GO:0050892 intestinal absorption 5/982 41/18722 0.0618542366390549 0.301243415788338 ACO1/LDLR/TJP2/LIMA1/F11R 5 GO:0055023 positive regulation of cardiac muscle tissue growth 5/982 41/18722 0.0618542366390549 0.301243415788338 FGFR2/PARP2/YAP1/TGFBR3/RBPJ 5 GO:0071470 cellular response to osmotic stress 5/982 41/18722 0.0618542366390549 0.301243415788338 SLC2A1/CLN3/AKR1B1/BAD/LRRC8D 5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 5/982 41/18722 0.0618542366390549 0.301243415788338 NRP1/DOCK1/TRIOBP/FERMT2/P4HB 5 GO:0030834 regulation of actin filament depolymerization 6/982 54/18722 0.0624671167240513 0.303378473773418 SCIN/SWAP70/TRIOBP/EPS8/LIMA1/GSN 6 GO:0070228 regulation of lymphocyte apoptotic process 6/982 54/18722 0.0624671167240513 0.303378473773418 GPAM/EFNA1/SLC39A10/CCL5/IRS2/BCL10 6 GO:0086002 cardiac muscle cell action potential involved in contraction 6/982 54/18722 0.0624671167240513 0.303378473773418 GJA1/GJA5/DSG2/DSP/DSC2/PKP2 6 GO:0009612 response to mechanical stimulus 17/982 216/18722 0.0625416494332759 0.303457900878109 GJA1/DAG1/EGFR/TMEM150C/MMP14/ABHD12/PTN/SLC2A1/SLC1A3/USP53/PTK2/CYBA/SLC38A2/GSN/BAD/F11R/BCL10 17 GO:0030336 negative regulation of cell migration 25/982 344/18722 0.06261947896413 0.303501543349125 GJA1/DAG1/SEMA6D/CDH1/KANK1/NR2F2/LRP1/CD200/TACSTD2/TCAF1/GNA12/PTPRK/PPARG/PTN/NF1/DLG5/ADGRG1/CLDN19/MARVELD3/SERPINF1/WASL/PPARD/GSTP1/DPP4/CLIC4 25 GO:0001916 positive regulation of T cell mediated cytotoxicity 4/982 29/18722 0.0630161371639384 0.303501543349125 B2M/HLA-B/HLA-A/HLA-E 4 GO:0006656 phosphatidylcholine biosynthetic process 4/982 29/18722 0.0630161371639384 0.303501543349125 CDS1/RAB38/CHPT1/SLC44A1 4 GO:0021522 spinal cord motor neuron differentiation 4/982 29/18722 0.0630161371639384 0.303501543349125 ISL1/SOX4/GLI3/LMO4 4 GO:0021591 ventricular system development 4/982 29/18722 0.0630161371639384 0.303501543349125 SEMA6D/CENPF/TSKU/CDK6 4 GO:0032366 intracellular sterol transport 4/982 29/18722 0.0630161371639384 0.303501543349125 SYT7/LRP6/LDLR/ANXA2 4 GO:0032367 intracellular cholesterol transport 4/982 29/18722 0.0630161371639384 0.303501543349125 SYT7/LRP6/LDLR/ANXA2 4 GO:0048679 regulation of axon regeneration 4/982 29/18722 0.0630161371639384 0.303501543349125 LRP1/PTN/PTPRF/GRN 4 GO:0061387 regulation of extent of cell growth 10/982 110/18722 0.0631367260723444 0.30366546798422 SEMA6D/SEMA6A/LRP1/NRP1/SEMA3F/SEMA4C/CYFIP1/CTTN/DPYSL2/MAP3K13 10 GO:0010594 regulation of endothelial cell migration 18/982 232/18722 0.063166609041963 0.30366546798422 PLPP3/NR2F2/MET/NRP2/NRP1/PPARG/PTN/NF1/TMSB4X/SERPINF1/EFNA1/PTK2/SPARC/LGMN/GRN/PLK2/PDPK1/ANXA3 18 GO:0003073 regulation of systemic arterial blood pressure 9/982 96/18722 0.0646219470869693 0.308306544486386 GJA1/ENPEP/NR2F2/ADRB1/GJA5/MME/ADM/NAV2/CYBA 9 GO:0043648 dicarboxylic acid metabolic process 9/982 96/18722 0.0646219470869693 0.308306544486386 SLC19A1/FOLR1/QPRT/IDH1/GCLM/SUCLA2/FH/ASS1/ATIC 9 GO:0044264 cellular polysaccharide metabolic process 9/982 96/18722 0.0646219470869693 0.308306544486386 GAA/SORBS1/IL6ST/AGL/B3GNT3/PHLDA2/PPP1R3E/IRS2/EXT2 9 GO:0001946 lymphangiogenesis 3/982 18/18722 0.06519595831451 0.308306544486386 PTPN14/ACVR2B/FOXC1 3 GO:0002544 chronic inflammatory response 3/982 18/18722 0.06519595831451 0.308306544486386 GJA1/PTGES/CCL5 3 GO:0044872 lipoprotein localization 3/982 18/18722 0.06519595831451 0.308306544486386 LRP1/PPARG/ZDHHC3 3 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 3/982 18/18722 0.06519595831451 0.308306544486386 HLA-B/HLA-A/HLA-E 3 GO:0046040 IMP metabolic process 3/982 18/18722 0.06519595831451 0.308306544486386 ADSL/PPAT/ATIC 3 GO:0055070 copper ion homeostasis 3/982 18/18722 0.06519595831451 0.308306544486386 APP/ANKRD9/SCO1 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/982 18/18722 0.06519595831451 0.308306544486386 PPARG/RBPMS/DAB2 3 GO:0060602 branch elongation of an epithelium 3/982 18/18722 0.06519595831451 0.308306544486386 FGFR2/YAP1/RDH10 3 GO:0061484 hematopoietic stem cell homeostasis 3/982 18/18722 0.06519595831451 0.308306544486386 SOX4/ADGRG1/FSTL1 3 GO:0071071 regulation of phospholipid biosynthetic process 3/982 18/18722 0.06519595831451 0.308306544486386 RAB38/PDGFA/IDH1 3 GO:0071360 cellular response to exogenous dsRNA 3/982 18/18722 0.06519595831451 0.308306544486386 COLEC12/ZCCHC3/DHX9 3 GO:0097094 craniofacial suture morphogenesis 3/982 18/18722 0.06519595831451 0.308306544486386 MMP14/GLI3/INSIG1 3 GO:0150079 negative regulation of neuroinflammatory response 3/982 18/18722 0.06519595831451 0.308306544486386 CD200/LDLR/GRN 3 GO:1902683 regulation of receptor localization to synapse 3/982 18/18722 0.06519595831451 0.308306544486386 DAG1/HRAS/ZDHHC3 3 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 3/982 18/18722 0.06519595831451 0.308306544486386 ISL1/TBX3/RBPJ 3 GO:0030522 intracellular receptor signaling pathway 20/982 265/18722 0.0657192709368203 0.310499743846426 ESRRG/NR2F2/SKP2/ISL1/YAP1/DCBLD2/PPARG/DAB2/MAP3K7/PUM1/HDAC6/ESRRA/PPARD/ZCCHC3/TRIM24/UBA5/TSPAN6/RXRA/PUM2/NR2F6 20 GO:0009410 response to xenobiotic stimulus 32/982 462/18722 0.066642912409886 0.314578670705851 CDH1/EGFR/SLC6A4/TFRC/DVL3/GNA12/ADIRF/PTN/SLC1A3/B2M/ALAD/CENPF/GSS/COMT/CYP2J2/BCAR3/MDM2/CYBA/DUSP6/PPOX/GSTP1/ATR/RPN2/PPAT/VAV3/USP47/GCLM/PGF/BAD/GSTA4/NME1/ASS1 32 GO:0019693 ribose phosphate metabolic process 28/982 396/18722 0.0672689853895227 0.315214515073048 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/SLC25A1/RPIA/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC 28 GO:0000266 mitochondrial fission 5/982 42/18722 0.0673215049446655 0.315214515073048 PPARG/INF2/MIEF1/PINK1/SLC25A46 5 GO:0006040 amino sugar metabolic process 5/982 42/18722 0.0673215049446655 0.315214515073048 EXTL2/MGAT3/FN3K/DPAGT1/GFPT1 5 GO:0014912 negative regulation of smooth muscle cell migration 5/982 42/18722 0.0673215049446655 0.315214515073048 SEMA6D/LRP1/GNA12/PPARD/GSTP1 5 GO:0016601 Rac protein signal transduction 5/982 42/18722 0.0673215049446655 0.315214515073048 CYFIP1/ALS2/NCKAP1/HACD3/EPS8 5 GO:0030574 collagen catabolic process 5/982 42/18722 0.0673215049446655 0.315214515073048 MMP14/CTSL/MMP15/ITGB1/CST3 5 GO:0035019 somatic stem cell population maintenance 5/982 42/18722 0.0673215049446655 0.315214515073048 LRP5/BMP7/SOX4/YAP1/RBPJ 5 GO:0042168 heme metabolic process 5/982 42/18722 0.0673215049446655 0.315214515073048 ALAD/NFE2L1/SLC11A2/PPOX/ALAS1 5 GO:0046596 regulation of viral entry into host cell 5/982 42/18722 0.0673215049446655 0.315214515073048 TRIML2/TRIM6/P4HB/GSN/TRIM27 5 GO:0048588 developmental cell growth 18/982 234/18722 0.0674153692989608 0.315370911446977 SEMA6D/SEMA6A/LRP1/APP/NRP2/COBL/PARP2/NRP1/SEMA3F/EIF2AK4/SEMA4C/CYFIP1/PAK6/CTTN/HDAC6/DPYSL2/MAP3K13/ITGB1 18 GO:0003002 regionalization 24/982 331/18722 0.0683895230419973 0.319641355006324 LRP2/NR2F2/PBX1/IRX2/WLS/LRP5/NRP2/BHLHE41/FGFR2/COBL/ISL1/NRP1/SEMA3F/PGAP1/ADGRG1/ACVR2B/LRP6/GLI3/AXIN2/BASP1/TBX3/AHI1/FOXC1/RBPJ 24 GO:0006643 membrane lipid metabolic process 16/982 203/18722 0.0685014085020699 0.319832968444697 PLPP3/PGAP2/PGAP1/B3GNT5/ITGB8/PIGU/DEGS1/HACD3/PIGF/FUCA1/SERINC2/PSAP/GPAA1/ST3GAL6/SPTLC3/NEU1 16 GO:0042770 signal transduction in response to DNA damage 14/982 172/18722 0.0686144731000031 0.319832968444697 SOX4/EIF2AK4/BRCC3/FOXO4/CCND1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/BRCA2/GTSE1/PTTG1IP/KMT5A 14 GO:1990138 neuron projection extension 14/982 172/18722 0.0686144731000031 0.319832968444697 SEMA6D/SEMA6A/LRP1/NRP2/NRP1/SEMA3F/EIF2AK4/SEMA4C/CYFIP1/PAK6/CTTN/DPYSL2/MAP3K13/ITGB1 14 GO:0006368 transcription elongation from RNA polymerase II promoter 7/982 69/18722 0.0691325995521059 0.321159254835384 BRD4/ELL/SERTAD1/SERTAD2/WDR43/CDCA4/ENY2 7 GO:0009145 purine nucleoside triphosphate biosynthetic process 7/982 69/18722 0.0691325995521059 0.321159254835384 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/ADK/NME1 7 GO:0060193 positive regulation of lipase activity 7/982 69/18722 0.0691325995521059 0.321159254835384 EGFR/FGFR2/FLT1/HRAS/P2RY6/CCL5/PDPK1 7 GO:0070646 protein modification by small protein removal 13/982 157/18722 0.0695005509840309 0.321159254835384 USP43/BRCC3/SPATA2/USP27X/USP53/USP39/WDR48/USP47/STAMBP/USP14/UCHL3/ENY2/USP25 13 GO:0043406 positive regulation of MAP kinase activity 10/982 112/18722 0.0695491751167655 0.321159254835384 EGFR/FZD10/DVL3/MAGED1/FLT1/HRAS/MAP3K7/CD24/PDGFA/MAP3K13 10 GO:0003015 heart process 19/982 251/18722 0.0697979421112299 0.321159254835384 GJA1/ADRB1/GJA5/DSG2/DSP/ISL1/DSC2/YAP1/GAA/EPAS1/ADM/ATP2B1/CYP2J2/MDM2/PKP2/EXT2/GSN/SMAD5/EHD3 19 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 4/982 30/18722 0.0698225833940425 0.321159254835384 CTSV/B2M/CTSL/LGMN 4 GO:0045948 positive regulation of translational initiation 4/982 30/18722 0.0698225833940425 0.321159254835384 EIF2AK4/YTHDF2/CCL5/METTL3 4 GO:0048147 negative regulation of fibroblast proliferation 4/982 30/18722 0.0698225833940425 0.321159254835384 PAWR/NF1/NUPR1/GSTP1 4 GO:0060351 cartilage development involved in endochondral bone morphogenesis 4/982 30/18722 0.0698225833940425 0.321159254835384 SERPINH1/TSKU/AXIN2/TRIP11 4 GO:0060603 mammary gland duct morphogenesis 4/982 30/18722 0.0698225833940425 0.321159254835384 LRP5/FGFR2/KDM5B/TBX3 4 GO:0060674 placenta blood vessel development 4/982 30/18722 0.0698225833940425 0.321159254835384 NR2F2/SPINT1/ITGB8/RBPJ 4 GO:0090314 positive regulation of protein targeting to membrane 4/982 30/18722 0.0698225833940425 0.321159254835384 TCAF1/MIEF1/HRAS/ANK3 4 GO:2000637 positive regulation of gene silencing by miRNA 4/982 30/18722 0.0698225833940425 0.321159254835384 EGFR/PUM1/PUM2/DHX9 4 GO:2000648 positive regulation of stem cell proliferation 4/982 30/18722 0.0698225833940425 0.321159254835384 GJA1/FERMT2/TBX3/CCNE1 4 GO:0050729 positive regulation of inflammatory response 12/982 142/18722 0.0700438415731725 0.321893108057857 EGFR/APP/IL6ST/LDLR/SNX4/TGM2/CEBPA/HLA-E/NUPR1/DHX9/GRN/FEM1A 12 GO:0030048 actin filament-based movement 11/982 127/18722 0.0701184755319581 0.321952436949554 GJA1/MYH10/GJA5/DSG2/DSP/DSC2/MYO7A/WASL/FNBP1L/PKP2/GSN 11 GO:0071383 cellular response to steroid hormone stimulus 16/982 204/18722 0.0708992851286145 0.32525124998316 ESRRG/EGFR/SKP2/BMP7/ISL1/YAP1/DAB2/SERPINF1/ATP2B1/HDAC6/ESRRA/PPARD/UBA5/RXRA/GSTP1/ASS1 16 GO:0016050 vesicle organization 22/982 300/18722 0.0712894665525474 0.326753829119585 HOOK2/SYT7/ANKRD27/MYO7A/HOOK1/ALS2/PRKCI/SYNJ1/WASL/RAB38/FNBP1L/RAB13/CLN3/HOOK3/TBC1D4/TFG/INSIG1/VAV3/SCARB2/CD2AP/ANXA2/TMED9 22 GO:0043473 pigmentation 9/982 98/18722 0.0716653694472585 0.327336662376749 ANKRD27/NF1/MYO7A/MREG/GNA11/GLI3/RAB38/HPS5/RAB17 9 GO:0061337 cardiac conduction 9/982 98/18722 0.0716653694472585 0.327336662376749 GJA1/GJA5/DSG2/DSP/ISL1/DSC2/ATP2B1/PKP2/EHD3 9 GO:1904029 regulation of cyclin-dependent protein kinase activity 9/982 98/18722 0.0716653694472585 0.327336662376749 NR2F2/EGFR/LATS2/CDKN1C/CCND1/CEBPA/SERTAD1/CCNE1/CCNA2 9 GO:0001658 branching involved in ureteric bud morphogenesis 6/982 56/18722 0.072044188728625 0.327336662376749 LGR4/PBX1/TACSTD2/LAMA5/MAGED1/GLI3 6 GO:0010332 response to gamma radiation 6/982 56/18722 0.072044188728625 0.327336662376749 YAP1/HRAS/MDM2/CYBA/ATR/BRCA2 6 GO:0031122 cytoplasmic microtubule organization 6/982 56/18722 0.072044188728625 0.327336662376749 DST/HOOK2/HOOK1/LIMK2/CAMSAP2/HOOK3 6 GO:0043388 positive regulation of DNA binding 6/982 56/18722 0.072044188728625 0.327336662376749 ISL1/PPARG/TRIM6/TRIM28/FOXC1/NME1 6 GO:0046622 positive regulation of organ growth 6/982 56/18722 0.072044188728625 0.327336662376749 FGFR2/PARP2/YAP1/TGFBR3/BASP1/RBPJ 6 GO:0071385 cellular response to glucocorticoid stimulus 6/982 56/18722 0.072044188728625 0.327336662376749 EGFR/ISL1/SERPINF1/ATP2B1/GSTP1/ASS1 6 GO:1990089 response to nerve growth factor 6/982 56/18722 0.072044188728625 0.327336662376749 APP/PTN/ID1/MICALL1/PDPK1/DYNC1LI2 6 GO:0006865 amino acid transport 12/982 143/18722 0.0730034514443627 0.330282163233203 GJA1/SLC38A9/SLC25A13/SLC1A3/SLC43A2/SLC1A5/CLN3/SLC7A6/ITGB1/SLC38A2/SLC7A2/LRRC8D 12 GO:0006509 membrane protein ectodomain proteolysis 5/982 43/18722 0.0730482266484262 0.330282163233203 DAG1/TIMP3/SH3D19/SPPL2B/BACE2 5 GO:0030517 negative regulation of axon extension 5/982 43/18722 0.0730482266484262 0.330282163233203 SEMA6D/SEMA6A/NRP1/SEMA3F/SEMA4C 5 GO:0032365 intracellular lipid transport 5/982 43/18722 0.0730482266484262 0.330282163233203 SYT7/PLEKHA8/LRP6/LDLR/ANXA2 5 GO:0042181 ketone biosynthetic process 5/982 43/18722 0.0730482266484262 0.330282163233203 ADM/HSD17B1/PDSS2/COQ5/COQ6 5 GO:0006112 energy reserve metabolic process 8/982 84/18722 0.0731357167435487 0.330282163233203 GAA/SORBS1/IL6ST/AGL/PHLDA2/PPP1R3E/GFPT1/IRS2 8 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 8/982 84/18722 0.0731357167435487 0.330282163233203 SOX4/WEE1/CTDSPL/CCND1/MDM2/TRIAP1/PLK2/GTSE1 8 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 17/982 221/18722 0.0738838277616538 0.331057450324297 GNA12/TMTC3/ALAD/DAB2/EFNA1/PTK2/CEBPA/MDM2/MAGEF1/PINK1/NUPR1/PLK2/PSME3/FBXO22/RAD23B/USP14/USP25 17 GO:0062012 regulation of small molecule metabolic process 24/982 334/18722 0.0740297603190447 0.331057450324297 SLC35B4/APP/SORBS1/PPARG/DDB1/RDH10/ADM/TMSB4X/LDLR/COMT/PHLDA2/PPP1R3E/CLN3/P2RY6/PPARD/C1QTNF1/ACADVL/PINK1/NUPR1/RANBP2/INSIG1/IRS2/BAD/LCMT1 24 GO:0002716 negative regulation of natural killer cell mediated immunity 3/982 19/18722 0.0745133141642493 0.331057450324297 HLA-B/HLA-A/HLA-E 3 GO:0002902 regulation of B cell apoptotic process 3/982 19/18722 0.0745133141642493 0.331057450324297 SLC39A10/IRS2/BCL10 3 GO:0006491 N-glycan processing 3/982 19/18722 0.0745133141642493 0.331057450324297 FUT8/PRKCSH/GANAB 3 GO:0006743 ubiquinone metabolic process 3/982 19/18722 0.0745133141642493 0.331057450324297 PDSS2/COQ5/COQ6 3 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 3/982 19/18722 0.0745133141642493 0.331057450324297 NME4/DTYMK/NME1 3 GO:0010544 negative regulation of platelet activation 3/982 19/18722 0.0745133141642493 0.331057450324297 UBASH3B/C1QTNF1/PDGFA 3 GO:0030011 maintenance of cell polarity 3/982 19/18722 0.0745133141642493 0.331057450324297 DST/DLG5/PDLIM1 3 GO:0030050 vesicle transport along actin filament 3/982 19/18722 0.0745133141642493 0.331057450324297 MYO7A/WASL/FNBP1L 3 GO:0032026 response to magnesium ion 3/982 19/18722 0.0745133141642493 0.331057450324297 CCND1/MDM2/ANK3 3 GO:0043031 negative regulation of macrophage activation 3/982 19/18722 0.0745133141642493 0.331057450324297 CD200/LDLR/GRN 3 GO:0044003 modulation by symbiont of host process 3/982 19/18722 0.0745133141642493 0.331057450324297 DAG1/RXRA/RRAGA 3 GO:0051546 keratinocyte migration 3/982 19/18722 0.0745133141642493 0.331057450324297 FERMT1/PPARD/MAP4K4 3 GO:0061323 cell proliferation involved in heart morphogenesis 3/982 19/18722 0.0745133141642493 0.331057450324297 ISL1/TBX3/RBPJ 3 GO:0070233 negative regulation of T cell apoptotic process 3/982 19/18722 0.0745133141642493 0.331057450324297 GPAM/EFNA1/CCL5 3 GO:0098780 response to mitochondrial depolarisation 3/982 19/18722 0.0745133141642493 0.331057450324297 HDAC6/PINK1/HUWE1 3 GO:2000042 negative regulation of double-strand break repair via homologous recombination 3/982 19/18722 0.0745133141642493 0.331057450324297 POLQ/RMI2/MAGEF1 3 GO:2000738 positive regulation of stem cell differentiation 3/982 19/18722 0.0745133141642493 0.331057450324297 TACSTD2/PTN/FOXC1 3 GO:0015980 energy derivation by oxidation of organic compounds 23/982 318/18722 0.0747281481864298 0.33172937952376 GAA/SORBS1/ACO1/SLC25A13/IL6ST/AGL/ADSL/PHLDA2/IL10RB/PPP1R3E/CYC1/GFPT1/ACADVL/PINK1/IDH1/NUPR1/DHTKD1/COX6A1/IRS2/SUCLA2/FH/OPN3/SURF1 23 GO:0046390 ribose phosphate biosynthetic process 15/982 190/18722 0.0750932108799127 0.333066486351722 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/SLC25A1/PINK1/SLC35B2/NME4/PPAT/IMPDH2/HSD17B12/ADK/NME1/ATIC 15 GO:0030838 positive regulation of actin filament polymerization 9/982 99/18722 0.0753586838915719 0.333676481475755 SCIN/FER/CYFIP1/CTTN/NCKAP1/WASL/GSN/RICTOR/TRIM27 9 GO:0060291 long-term synaptic potentiation 9/982 99/18722 0.0753586838915719 0.333676481475755 APP/SHANK2/MME/EIF2AK4/PTN/PPP1R9A/NSG1/LGMN/PLK2 9 GO:0015931 nucleobase-containing compound transport 17/982 222/18722 0.0763062740187313 0.337536375755167 GJA1/SLC35B4/SLC19A1/IGF2BP3/SLC25A36/SLC29A1/SLC25A4/NCBP3/SLC35B2/SLC25A17/DHX9/NUP153/RANBP2/SLC35D1/UPF3A/TST/ENY2 17 GO:0046660 female sex differentiation 10/982 114/18722 0.0763598396071889 0.337536375755167 LRP2/ADAMTS1/NR2F2/MMP14/CHD7/TBX3/IDH1/NUPR1/BRCA2/FOXC1 10 GO:0009259 ribonucleotide metabolic process 27/982 385/18722 0.0769441966505039 0.337622742595512 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC 27 GO:0036474 cell death in response to hydrogen peroxide 4/982 31/18722 0.0769896060371259 0.337622742595512 MET/PAWR/HDAC6/PINK1 4 GO:0060045 positive regulation of cardiac muscle cell proliferation 4/982 31/18722 0.0769896060371259 0.337622742595512 FGFR2/YAP1/TGFBR3/RBPJ 4 GO:0060148 positive regulation of posttranscriptional gene silencing 4/982 31/18722 0.0769896060371259 0.337622742595512 EGFR/PUM1/PUM2/DHX9 4 GO:0060390 regulation of SMAD protein signal transduction 4/982 31/18722 0.0769896060371259 0.337622742595512 LRP1/PPARG/RBPMS/DAB2 4 GO:0070633 transepithelial transport 4/982 31/18722 0.0769896060371259 0.337622742595512 ABCG2/CLDN19/SLC1A3/P2RY6 4 GO:0090183 regulation of kidney development 4/982 31/18722 0.0769896060371259 0.337622742595512 LGR4/TACSTD2/MAGED1/BASP1 4 GO:0010883 regulation of lipid storage 6/982 57/18722 0.0771309161862273 0.337622742595512 ITGAV/MEST/PPARG/HILPDA/PPARD/PNPLA2 6 GO:0033619 membrane protein proteolysis 6/982 57/18722 0.0771309161862273 0.337622742595512 DAG1/TIMP3/SH3D19/SPPL2B/AFG3L2/BACE2 6 GO:0060042 retina morphogenesis in camera-type eye 6/982 57/18722 0.0771309161862273 0.337622742595512 OBSL1/LRP5/NAGLU/PTN/TFAP2A/AHI1 6 GO:0061005 cell differentiation involved in kidney development 6/982 57/18722 0.0771309161862273 0.337622742595512 LGR4/YAP1/GLI3/CD24/BASP1/MTSS1 6 GO:0009142 nucleoside triphosphate biosynthetic process 8/982 85/18722 0.0772208458428769 0.337622742595512 SLC25A13/TMSB4X/PINK1/NME4/DTYMK/IMPDH2/ADK/NME1 8 GO:0032092 positive regulation of protein binding 8/982 85/18722 0.0772208458428769 0.337622742595512 LRP1/APP/NRP1/B2M/PPP2CB/PLK2/TCF7L2/ANXA2 8 GO:0006164 purine nucleotide biosynthetic process 15/982 191/18722 0.077751970143236 0.339660197878659 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/SLC25A1/PINK1/SLC35B2/NME4/PPAT/IMPDH2/HSD17B12/ADK/NME1/ATIC 15 GO:0045824 negative regulation of innate immune response 7/982 71/18722 0.0780605972877224 0.340438190177893 PPARG/HLA-B/HLA-A/HLA-E/YTHDF2/GRN/METTL3 7 GO:0150116 regulation of cell-substrate junction organization 7/982 71/18722 0.0780605972877224 0.340438190177893 LRP1/NRP1/MMP14/EFNA5/PTK2/FERMT2/MAP4K4 7 GO:0045860 positive regulation of protein kinase activity 27/982 386/18722 0.078805614195119 0.342669296739375 DAG1/EGFR/PRLR/FZD10/DVL3/MAGED1/EFNA5/PPP1R9A/ERBB3/TRAF4/ALS2/FLT1/HRAS/EFNA1/PTK2/CCND1/MAP3K7/CD24/FERMT2/CCL5/PDGFA/MAP3K13/PINK1/TPX2/RICTOR/CACUL1/PDPK1 27 GO:0021517 ventral spinal cord development 5/982 44/18722 0.0790320483085637 0.342669296739375 VSTM5/ISL1/SOX4/GLI3/LMO4 5 GO:0032881 regulation of polysaccharide metabolic process 5/982 44/18722 0.0790320483085637 0.342669296739375 SORBS1/PHLDA2/PPP1R3E/CLTC/IRS2 5 GO:0048066 developmental pigmentation 5/982 44/18722 0.0790320483085637 0.342669296739375 ANKRD27/MREG/GNA11/GLI3/RAB38 5 GO:0048806 genitalia development 5/982 44/18722 0.0790320483085637 0.342669296739375 LRP2/LGR4/CHD7/DHCR24/TBX3 5 GO:0089718 amino acid import across plasma membrane 5/982 44/18722 0.0790320483085637 0.342669296739375 SLC1A3/SLC43A2/SLC1A5/ITGB1/SLC7A2 5 GO:0150076 neuroinflammatory response 5/982 44/18722 0.0790320483085637 0.342669296739375 CD200/LDLR/NUPR1/ITGB1/GRN 5 GO:0045807 positive regulation of endocytosis 9/982 100/18722 0.0791667559106759 0.342968271453559 LRP1/B2M/DAB2/SYNJ1/WASL/CLN3/RAB31/AHI1/ANXA2 9 GO:0030278 regulation of ossification 10/982 115/18722 0.0799153509088515 0.345924041776406 FBN2/PBX1/BMP7/PTN/NOTUM/ACVR2B/ATP2B1/TFAP2A/ESRRA/RBPJ 10 GO:0048872 homeostasis of number of cells 20/982 272/18722 0.080717384940996 0.349106036361721 LGR4/SOX4/TGFBR3/GPAM/EPAS1/ADGRG1/JAM3/B2M/RCOR1/SLC11A2/CDK6/UBA5/PRDX1/FSTL1/SLC39A3/WDR48/SMAD5/FH/ALAS1/BCL10 20 GO:0051650 establishment of vesicle localization 13/982 161/18722 0.0810740985930448 0.350186245090177 MYO7A/MREG/LIMK2/SYNJ1/WASL/FNBP1L/CLN3/PINK1/TFG/RAB17/AP1M2/TRIP11/TMED9 13 GO:1901293 nucleoside phosphate biosynthetic process 19/982 256/18722 0.0811014156573877 0.350186245090177 SLC26A2/ACSS1/SLC25A13/TK1/TMSB4X/ADSL/QPRT/SLC25A1/PINK1/SLC35B2/NME4/PPAT/DTYMK/IMPDH2/HSD17B12/ADK/NME1/ATIC/RRM1 19 GO:0016054 organic acid catabolic process 18/982 240/18722 0.0813103979205301 0.350776791372695 GLDC/SLC27A2/ACADS/ECI1/GSTZ1/QPRT/PPARD/ACADVL/SLC25A17/DECR2/PPAT/ECHDC2/IRS2/TST/GCSH/CDO1/ENOSF1/HADHB 18 GO:0006493 protein O-linked glycosylation 8/982 86/18722 0.0814399337331927 0.350776791372695 GALNT18/B3GNT5/TMTC3/GXYLT1/GALNT11/B3GNT3/B4GAT1/TET2 8 GO:0015908 fatty acid transport 8/982 86/18722 0.0814399337331927 0.350776791372695 SLC27A2/PPARG/SLC2A1/PTGES/PLA2G12A/PPARD/SLC25A17/IRS2 8 GO:0007159 leukocyte cell-cell adhesion 26/982 371/18722 0.0818784701307634 0.352374670133714 BMP7/SOCS6/SOX4/TFRC/PAWR/IL6ST/GPAM/DLG5/B2M/TNFRSF21/CD46/HLA-A/OLR1/NFAT5/GLI3/YES1/CD24/HLA-E/CCL5/ITGB1/DPP4/FLOT2/BAD/F11R/ASS1/BCL10 26 GO:0043405 regulation of MAP kinase activity 14/982 177/18722 0.0823986022144398 0.353227303387255 EGFR/FZD10/BMP7/DVL3/PPARG/MAGED1/NF1/FLT1/HRAS/MAP3K7/CD24/PDGFA/MAP3K13/GSTP1 14 GO:0098739 import across plasma membrane 14/982 177/18722 0.0823986022144398 0.353227303387255 LRP2/SLC19A1/WNK2/FOLR1/SLC2A1/SLC1A3/TRPV6/SLC43A2/SLC1A5/SLC39A10/ITGB1/IRS2/SLC7A2/SLC5A3 14 GO:0001954 positive regulation of cell-matrix adhesion 6/982 58/18722 0.0824151894597947 0.353227303387255 DAG1/FERMT1/NRP1/FERMT2/CDK6/MAP4K4 6 GO:0035904 aorta development 6/982 58/18722 0.0824151894597947 0.353227303387255 LRP2/LRP1/ADAMTS6/SOX4/CHD7/RBPJ 6 GO:0086065 cell communication involved in cardiac conduction 6/982 58/18722 0.0824151894597947 0.353227303387255 GJA1/GJA5/DSG2/DSP/DSC2/PKP2 6 GO:0000271 polysaccharide biosynthetic process 7/982 72/18722 0.0827647509258992 0.353563424102777 SORBS1/AGL/B3GNT3/PPP1R3E/CLTC/IRS2/EXT2 7 GO:0005977 glycogen metabolic process 7/982 72/18722 0.0827647509258992 0.353563424102777 GAA/SORBS1/IL6ST/AGL/PHLDA2/PPP1R3E/IRS2 7 GO:0042246 tissue regeneration 7/982 72/18722 0.0827647509258992 0.353563424102777 DAG1/YAP1/PTN/PPARD/BIN3/CPQ/KLF5 7 GO:0055021 regulation of cardiac muscle tissue growth 7/982 72/18722 0.0827647509258992 0.353563424102777 GJA1/FGFR2/PARP2/YAP1/TGFBR3/VGLL4/RBPJ 7 GO:0006612 protein targeting to membrane 11/982 131/18722 0.0832468762843489 0.355332002208808 TCAF1/MIEF1/TRAM2/HRAS/PRKCI/PARD3/MICALL1/ZDHHC3/ANK3/SEC63/SIL1 11 GO:0060047 heart contraction 18/982 241/18722 0.0837964024072386 0.356058704863185 GJA1/ADRB1/GJA5/DSG2/DSP/ISL1/DSC2/GAA/EPAS1/ADM/ATP2B1/CYP2J2/MDM2/PKP2/EXT2/GSN/SMAD5/EHD3 18 GO:0003215 cardiac right ventricle morphogenesis 3/982 20/18722 0.0843817388162707 0.356058704863185 ISL1/SOX4/CHD7 3 GO:0032930 positive regulation of superoxide anion generation 3/982 20/18722 0.0843817388162707 0.356058704863185 EGFR/CYBA/GSTP1 3 GO:0039535 regulation of RIG-I signaling pathway 3/982 20/18722 0.0843817388162707 0.356058704863185 PUM1/ZCCHC3/PUM2 3 GO:0060252 positive regulation of glial cell proliferation 3/982 20/18722 0.0843817388162707 0.356058704863185 EGFR/ETV5/PRKCI 3 GO:0003338 metanephros morphogenesis 4/982 32/18722 0.0845093321741993 0.356058704863185 LGR4/FRAS1/KIF26B/BASP1 4 GO:0006026 aminoglycan catabolic process 4/982 32/18722 0.0845093321741993 0.356058704863185 NAGLU/GNS/FUCA1/GUSB 4 GO:0010644 cell communication by electrical coupling 4/982 32/18722 0.0845093321741993 0.356058704863185 GJA1/GJA5/PKP2/ANK3 4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 4/982 32/18722 0.0845093321741993 0.356058704863185 FERMT1/TGFBR3/DAB2/CDKN1C 4 GO:0033687 osteoblast proliferation 4/982 32/18722 0.0845093321741993 0.356058704863185 PLXNB1/ITGAV/LRP5/FGFR2 4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 4/982 32/18722 0.0845093321741993 0.356058704863185 NR2F2/LATS2/CDKN1C/CEBPA 4 GO:0051642 centrosome localization 4/982 32/18722 0.0845093321741993 0.356058704863185 ASPM/PARD3/RANBP2/DYNC1LI2 4 GO:0060317 cardiac epithelial to mesenchymal transition 4/982 32/18722 0.0845093321741993 0.356058704863185 TGFBR3/EFNA1/TBX3/RBPJ 4 GO:0090140 regulation of mitochondrial fission 4/982 32/18722 0.0845093321741993 0.356058704863185 PPARG/INF2/MIEF1/PINK1 4 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 4/982 32/18722 0.0845093321741993 0.356058704863185 FERMT1/TGFBR3/DAB2/CDKN1C 4 GO:1905476 negative regulation of protein localization to membrane 4/982 32/18722 0.0845093321741993 0.356058704863185 DAB2/CLTC/PPFIA1/LYPLA1 4 GO:0030850 prostate gland development 5/982 45/18722 0.0852699533265907 0.357530608160367 FGFR2/BMP7/SERPINF1/GLI3/PSAP 5 GO:0031670 cellular response to nutrient 5/982 45/18722 0.0852699533265907 0.357530608160367 FOLR1/PTN/ATP2B1/MDM2/TRIM24 5 GO:0071354 cellular response to interleukin-6 5/982 45/18722 0.0852699533265907 0.357530608160367 YAP1/IL6ST/FER/CEBPA/ST3GAL6 5 GO:0071364 cellular response to epidermal growth factor stimulus 5/982 45/18722 0.0852699533265907 0.357530608160367 EGFR/ID1/GSTP1/FOXC1/PDPK1 5 GO:1904646 cellular response to amyloid-beta 5/982 45/18722 0.0852699533265907 0.357530608160367 GJA1/LRP1/APP/IGF1R/LGMN 5 GO:2000273 positive regulation of signaling receptor activity 5/982 45/18722 0.0852699533265907 0.357530608160367 NRP1/NCOA3/HDAC6/PINK1/ITGB1 5 GO:0048015 phosphatidylinositol-mediated signaling 14/982 178/18722 0.0853532093130247 0.357592240784527 PLXNB1/EGFR/PIP5K1A/NF1/ERBB3/IGF1R/FLT1/PTK2/PPARD/CCL5/PDGFA/STAMBP/PIP5K1B/HCST 14 GO:1902850 microtubule cytoskeleton organization involved in mitosis 12/982 147/18722 0.0856370487266459 0.358493455985702 GJA1/TACC2/GNAI1/EML1/SPDL1/RACGAP1/CLTC/ITGB1/PLK2/TPX2/DCTN6/KIF4A 12 GO:0016101 diterpenoid metabolic process 8/982 87/18722 0.0857928179068849 0.358569982533904 LRP2/EGFR/LRP1/RDH10/RDH14/PPARD/PNPLA2/AKR1B1 8 GO:0019915 lipid storage 8/982 87/18722 0.0857928179068849 0.358569982533904 ITGAV/MEST/PPARG/CDS1/SQLE/HILPDA/PPARD/PNPLA2 8 GO:0051090 regulation of DNA-binding transcription factor activity 30/982 440/18722 0.0860238483508292 0.359247255744797 PLPP3/CD200/APP/LRP5/BMP7/TRIML2/TFRC/EIF2AK4/PPARG/FER/LRP6/ID1/TMSB4X/WFS1/PRKCI/TRIM6/MAP3K7/FZD6/MAP3K13/PINK1/TRIM37/NUPR1/DHX9/FLOT2/RPS6KA4/TCF7L2/TRIM27/NLRP2/ANXA3/BCL10 30 GO:1901654 response to ketone 15/982 194/18722 0.0860926130523381 0.359247255744797 EGFR/YAP1/CLDN4/TGFBR3/PTN/GNAI1/SERPINF1/ATP2B1/CCND1/P2RY6/CYBA/AKR1B1/BAD/NME1/ASS1 15 GO:0007346 regulation of mitotic cell cycle 31/982 457/18722 0.0863169107307017 0.359895288865979 ADAMTS1/PBX1/EGFR/OBSL1/APP/LRP5/BMP7/SOX4/WEE1/DDB1/BRD4/CENPF/MTA3/CDKN1C/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/LGMN/PLK2/TOPBP1/PSME3/BRCA2/GTSE1/USP47/FOXC1/LCMT1 31 GO:0051656 establishment of organelle localization 27/982 390/18722 0.0865574437566474 0.360609925427055 GJA1/FER/MYO7A/MREG/CENPF/LIMK2/ARHGAP21/SYNJ1/SNX4/PARD3/WASL/FNBP1L/CLN3/SPDL1/HDAC6/ARMCX3/HOOK3/PINK1/TFG/ITGB1/ABCE1/RAB17/AP1M2/LSG1/TRIP11/TMED9/PDPK1 27 GO:0061025 membrane fusion 13/982 163/18722 0.0872942878361965 0.362753220282388 SPESP1/SYT7/ANKRD27/FOLR1/CTSL/RAB13/MYOF/CLN3/TBC1D4/VAV3/ANXA2/NAPA/HUWE1 13 GO:0072331 signal transduction by p53 class mediator 13/982 163/18722 0.0872942878361965 0.362753220282388 SOX4/PERP/RPF2/MDM2/TRIM24/TRIAP1/NUPR1/ATR/PLK2/BRCA2/GTSE1/PTTG1IP/KMT5A 13 GO:0006073 cellular glucan metabolic process 7/982 73/18722 0.0876282702369267 0.362753220282388 GAA/SORBS1/IL6ST/AGL/PHLDA2/PPP1R3E/IRS2 7 GO:0032456 endocytic recycling 7/982 73/18722 0.0876282702369267 0.362753220282388 ANKRD27/NSG1/SNX4/RAB13/MICALL1/RAB17/EHD3 7 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 7/982 73/18722 0.0876282702369267 0.362753220282388 LRP1/LRP5/EFNA5/PPARD/MAP4K4/BAD/ENY2 7 GO:0035924 cellular response to vascular endothelial growth factor stimulus 7/982 73/18722 0.0876282702369267 0.362753220282388 SEMA6A/NRP2/NRP1/GAB1/FLT1/FOXC1/PGF 7 GO:0044042 glucan metabolic process 7/982 73/18722 0.0876282702369267 0.362753220282388 GAA/SORBS1/IL6ST/AGL/PHLDA2/PPP1R3E/IRS2 7 GO:0086003 cardiac muscle cell contraction 7/982 73/18722 0.0876282702369267 0.362753220282388 GJA1/GJA5/DSG2/DSP/DSC2/PKP2/GSN 7 GO:0033013 tetrapyrrole metabolic process 6/982 59/18722 0.0878955785940032 0.363283152096926 ALAD/NFE2L1/SLC11A2/PPOX/SUCLA2/ALAS1 6 GO:0048010 vascular endothelial growth factor receptor signaling pathway 6/982 59/18722 0.0878955785940032 0.363283152096926 NRP1/FLT1/EPN2/PTK2/FOXC1/PGF 6 GO:0007626 locomotory behavior 14/982 179/18722 0.088374221103793 0.36497223854108 MCOLN3/APP/NAGLU/ZFHX3/GAA/ABHD12/CHD7/PAK6/ALS2/PUM1/NAV2/EPS8/UBA6/DPP4 14 GO:0010595 positive regulation of endothelial cell migration 11/982 133/18722 0.0903450634412916 0.367793923455339 PLPP3/MET/NRP2/NRP1/TMSB4X/SPARC/LGMN/GRN/PLK2/PDPK1/ANXA3 11 GO:0050806 positive regulation of synaptic transmission 13/982 164/18722 0.0905133851928453 0.367793923455339 EGFR/APP/SHANK2/MME/EIF2AK4/PTN/SLC1A3/PPP1R9A/NSG1/PINK1/LGMN/ZDHHC3/PLK2 13 GO:0006260 DNA replication 19/982 260/18722 0.0909695754196672 0.367793923455339 EGFR/NFIB/POLQ/MCM2/CHTF8/HRAS/WRNIP1/FEN1/BCAR3/RMI2/WDHD1/ATR/DHX9/TOPBP1/BRCA2/TOP1/CCNE1/CCNA2/RRM1 19 GO:0007613 memory 10/982 118/18722 0.0911843542210775 0.367793923455339 SLC6A4/EIF2AK4/PTN/PAK6/LDLR/SERPINF1/COMT/FEN1/LGMN/PLK2 10 GO:0051101 regulation of DNA binding 10/982 118/18722 0.0911843542210775 0.367793923455339 ISL1/PPARG/ZBTB7C/ID1/TMSB4X/TRIM6/ZNF593/TRIM28/FOXC1/NME1 10 GO:0002027 regulation of heart rate 9/982 103/18722 0.0912799259665156 0.367793923455339 ADRB1/DSG2/DSP/ISL1/DSC2/EPAS1/ADM/MDM2/PKP2 9 GO:0043616 keratinocyte proliferation 5/982 46/18722 0.0917582927695973 0.367793923455339 FGFR2/YAP1/FERMT1/PTPRK/PPARD 5 GO:0010165 response to X-ray 4/982 33/18722 0.0923727672747969 0.367793923455339 BRCC3/CCND1/BRCA2/IKBIP 4 GO:0048333 mesodermal cell differentiation 4/982 33/18722 0.0923727672747969 0.367793923455339 ITGB4/GJA1/FGFR2/ITGB1 4 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 4/982 33/18722 0.0923727672747969 0.367793923455339 ZNF451/MED16/CAND1/MED24 4 GO:0061842 microtubule organizing center localization 4/982 33/18722 0.0923727672747969 0.367793923455339 ASPM/PARD3/RANBP2/DYNC1LI2 4 GO:0071353 cellular response to interleukin-4 4/982 33/18722 0.0923727672747969 0.367793923455339 ALAD/MCM2/IMPDH2/IL2RG 4 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 4/982 33/18722 0.0923727672747969 0.367793923455339 KANK1/TACSTD2/YAP1/LIMK2 4 GO:1900181 negative regulation of protein localization to nucleus 4/982 33/18722 0.0923727672747969 0.367793923455339 TRIM29/FERMT1/MAGED1/LATS2 4 GO:1902692 regulation of neuroblast proliferation 4/982 33/18722 0.0923727672747969 0.367793923455339 PTN/NF1/ASPM/GLI3 4 GO:1903146 regulation of autophagy of mitochondrion 4/982 33/18722 0.0923727672747969 0.367793923455339 CTTN/SLC25A4/HDAC6/PINK1 4 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/982 33/18722 0.0923727672747969 0.367793923455339 NR2F2/LATS2/CDKN1C/CEBPA 4 GO:0016525 negative regulation of angiogenesis 12/982 149/18722 0.092433791084841 0.367793923455339 ADAMTS1/SEMA6A/COL4A2/PPARG/PTN/AMOT/SERPINF1/EPN2/FOXO4/SPARC/PLK2/FOXC1 12 GO:0045834 positive regulation of lipid metabolic process 12/982 149/18722 0.092433791084841 0.367793923455339 SORBS1/PPARG/RDH10/ADM/FLT1/LDLR/RAB38/PTK2/PPARD/PNPLA2/VAV3/IRS2 12 GO:0060326 cell chemotaxis 22/982 310/18722 0.0930763847491616 0.367793923455339 MET/PIP5K1A/TPBG/CSF3R/NRP1/SWAP70/PTN/JAM3/GAB1/TMSB4X/FLT1/PTK2/RAB13/CCL5/MPP1/LGMN/GSTP1/VAV3/DPP4/CREB3/BSG/PGF 22 GO:0000050 urea cycle 2/982 10/18722 0.0935161325299247 0.367793923455339 CEBPA/ASS1 2 GO:0000098 sulfur amino acid catabolic process 2/982 10/18722 0.0935161325299247 0.367793923455339 TST/CDO1 2 GO:0002002 regulation of angiotensin levels in blood 2/982 10/18722 0.0935161325299247 0.367793923455339 ENPEP/MME 2 GO:0002003 angiotensin maturation 2/982 10/18722 0.0935161325299247 0.367793923455339 ENPEP/MME 2 GO:0002084 protein depalmitoylation 2/982 10/18722 0.0935161325299247 0.367793923455339 ABHD12/LYPLA1 2 GO:0003163 sinoatrial node development 2/982 10/18722 0.0935161325299247 0.367793923455339 ISL1/TBX3 2 GO:0003183 mitral valve morphogenesis 2/982 10/18722 0.0935161325299247 0.367793923455339 SOX4/EFNA1 2 GO:0006228 UTP biosynthetic process 2/982 10/18722 0.0935161325299247 0.367793923455339 NME4/NME1 2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 2/982 10/18722 0.0935161325299247 0.367793923455339 RTCB/DDX1 2 GO:0010172 embryonic body morphogenesis 2/982 10/18722 0.0935161325299247 0.367793923455339 DAG1/ZNF281 2 GO:0010944 negative regulation of transcription by competitive promoter binding 2/982 10/18722 0.0935161325299247 0.367793923455339 BHLHE41/TFAP2A 2 GO:0010992 ubiquitin recycling 2/982 10/18722 0.0935161325299247 0.367793923455339 TRIM6/PINK1 2 GO:0015911 long-chain fatty acid import across plasma membrane 2/982 10/18722 0.0935161325299247 0.367793923455339 SLC2A1/IRS2 2 GO:0016139 glycoside catabolic process 2/982 10/18722 0.0935161325299247 0.367793923455339 FUCA1/GUSB 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/982 10/18722 0.0935161325299247 0.367793923455339 P4HB/PRDX4 2 GO:0021562 vestibulocochlear nerve development 2/982 10/18722 0.0935161325299247 0.367793923455339 NRP2/NRP1 2 GO:0021932 hindbrain radial glia guided cell migration 2/982 10/18722 0.0935161325299247 0.367793923455339 ITGB1/RERE 2 GO:0032025 response to cobalt ion 2/982 10/18722 0.0935161325299247 0.367793923455339 ALAD/SERPINF1 2 GO:0033131 regulation of glucokinase activity 2/982 10/18722 0.0935161325299247 0.367793923455339 RANBP2/BAD 2 GO:0033572 transferrin transport 2/982 10/18722 0.0935161325299247 0.367793923455339 TFRC/CLTC 2 GO:0035376 sterol import 2/982 10/18722 0.0935161325299247 0.367793923455339 LRP1/LDLR 2 GO:0035646 endosome to melanosome transport 2/982 10/18722 0.0935161325299247 0.367793923455339 ANKRD27/RAB38 2 GO:0040015 negative regulation of multicellular organism growth 2/982 10/18722 0.0935161325299247 0.367793923455339 ADRB1/LGMN 2 GO:0042996 regulation of Golgi to plasma membrane protein transport 2/982 10/18722 0.0935161325299247 0.367793923455339 CLN3/LYPLA1 2 GO:0043485 endosome to pigment granule transport 2/982 10/18722 0.0935161325299247 0.367793923455339 ANKRD27/RAB38 2 GO:0048194 Golgi vesicle budding 2/982 10/18722 0.0935161325299247 0.367793923455339 PRKCI/TMED9 2 GO:0048757 pigment granule maturation 2/982 10/18722 0.0935161325299247 0.367793923455339 ANKRD27/RAB38 2 GO:0051351 positive regulation of ligase activity 2/982 10/18722 0.0935161325299247 0.367793923455339 TMSB4X/GCLM 2 GO:0051409 response to nitrosative stress 2/982 10/18722 0.0935161325299247 0.367793923455339 DUSP6/GCLM 2 GO:0060736 prostate gland growth 2/982 10/18722 0.0935161325299247 0.367793923455339 FGFR2/PSAP 2 GO:0060923 cardiac muscle cell fate commitment 2/982 10/18722 0.0935161325299247 0.367793923455339 TBX3/RBPJ 2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 2/982 10/18722 0.0935161325299247 0.367793923455339 MAP4K4/ENY2 2 GO:0070508 cholesterol import 2/982 10/18722 0.0935161325299247 0.367793923455339 LRP1/LDLR 2 GO:0090179 planar cell polarity pathway involved in neural tube closure 2/982 10/18722 0.0935161325299247 0.367793923455339 DVL3/NPHP3 2 GO:0090647 modulation of age-related behavioral decline 2/982 10/18722 0.0935161325299247 0.367793923455339 APP/B2M 2 GO:0098885 modification of postsynaptic actin cytoskeleton 2/982 10/18722 0.0935161325299247 0.367793923455339 MYH10/CYFIP1 2 GO:0150172 regulation of phosphatidylcholine metabolic process 2/982 10/18722 0.0935161325299247 0.367793923455339 LDLR/RAB38 2 GO:1902023 L-arginine transport 2/982 10/18722 0.0935161325299247 0.367793923455339 SLC38A9/SLC7A2 2 GO:1902946 protein localization to early endosome 2/982 10/18722 0.0935161325299247 0.367793923455339 MGAT3/NRP1 2 GO:1903826 arginine transmembrane transport 2/982 10/18722 0.0935161325299247 0.367793923455339 SLC38A9/SLC7A2 2 GO:2000234 positive regulation of rRNA processing 2/982 10/18722 0.0935161325299247 0.367793923455339 WDR43/HEATR1 2 GO:2000288 positive regulation of myoblast proliferation 2/982 10/18722 0.0935161325299247 0.367793923455339 PPARD/MALAT1 2 GO:2000674 regulation of type B pancreatic cell apoptotic process 2/982 10/18722 0.0935161325299247 0.367793923455339 WFS1/TCF7L2 2 GO:0006893 Golgi to plasma membrane transport 6/982 60/18722 0.0935702715539178 0.367793923455339 CLN3/KRT18/RAB31/ANK3/LYPLA1/EXOC2 6 GO:0071772 response to BMP 13/982 165/18722 0.093805267881613 0.368162736847625 LRP2/FBN1/BMP7/SPINT1/TGFBR3/PPARG/SPINT2/ACVR2B/DLX5/CRIM1/FSTL1/SMAD5/RBPJ 13 GO:0071773 cellular response to BMP stimulus 13/982 165/18722 0.093805267881613 0.368162736847625 LRP2/FBN1/BMP7/SPINT1/TGFBR3/PPARG/SPINT2/ACVR2B/DLX5/CRIM1/FSTL1/SMAD5/RBPJ 13 GO:0001508 action potential 11/982 134/18722 0.0940279491857577 0.368759235302942 GJA1/GJA5/DSG2/DSP/DSC2/CLDN19/GNA11/USP53/CLN3/PKP2/ANK3 11 GO:0003091 renal water homeostasis 3/982 21/18722 0.094772670867969 0.368906157647258 ATP6V1B1/WFS1/AKR1B1 3 GO:0009067 aspartate family amino acid biosynthetic process 3/982 21/18722 0.094772670867969 0.368906157647258 PLOD2/ASNSD1/AASDHPPT 3 GO:0032288 myelin assembly 3/982 21/18722 0.094772670867969 0.368906157647258 ITGB4/GPC1/EPB41L3 3 GO:0033630 positive regulation of cell adhesion mediated by integrin 3/982 21/18722 0.094772670867969 0.368906157647258 FERMT1/IFT74/CCL5 3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 3/982 21/18722 0.094772670867969 0.368906157647258 CYFIP1/NCKAP1/WASL 3 GO:0060117 auditory receptor cell development 3/982 21/18722 0.094772670867969 0.368906157647258 MYO7A/TRIOBP/TPRN 3 GO:0090026 positive regulation of monocyte chemotaxis 3/982 21/18722 0.094772670867969 0.368906157647258 CCL5/LGMN/CREB3 3 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 3/982 21/18722 0.094772670867969 0.368906157647258 LGR4/TACSTD2/MAGED1 3 GO:0099515 actin filament-based transport 3/982 21/18722 0.094772670867969 0.368906157647258 MYO7A/WASL/FNBP1L 3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/982 21/18722 0.094772670867969 0.368906157647258 MDM2/TRIAP1/PTTG1IP 3 GO:1900407 regulation of cellular response to oxidative stress 8/982 89/18722 0.0948984413900175 0.369120261215758 MET/BMP7/PAWR/FUT8/PAGE4/HDAC6/P4HB/PINK1 8 GO:0010906 regulation of glucose metabolic process 10/982 119/18722 0.0951414318606243 0.369514302743869 SLC35B4/SORBS1/DDB1/PHLDA2/PPP1R3E/C1QTNF1/RANBP2/IRS2/BAD/LCMT1 10 GO:0030282 bone mineralization 10/982 119/18722 0.0951414318606243 0.369514302743869 FBN2/LGR4/FGFR2/BMP7/PTN/NOTUM/ACVR2B/ATP2B1/TFAP2A/AXIN2 10 GO:0031349 positive regulation of defense response 20/982 278/18722 0.0952547636430566 0.369679201757577 GJA1/EGFR/APP/CADM1/IL6ST/LDLR/TRIM6/SNX4/TGM2/MAP3K7/CEBPA/HLA-E/ZCCHC3/CCL5/CYBA/PSPC1/NUPR1/DHX9/GRN/FEM1A 20 GO:0006892 post-Golgi vesicle-mediated transport 9/982 104/18722 0.0955467928739847 0.370536856231007 KIF16B/SCAMP1/CLN3/KRT18/RAB31/ANK3/LYPLA1/EHD3/EXOC2 9 GO:0070665 positive regulation of leukocyte proliferation 12/982 150/18722 0.0959524400031369 0.371833526787787 TFRC/IL6ST/GPAM/CD46/HLA-A/SLC39A10/PTK2/CD24/HLA-E/CCL5/VAV3/IRS2 12 GO:0031330 negative regulation of cellular catabolic process 19/982 262/18722 0.0961822340001355 0.372447314435565 MET/MGAT3/ALAD/EFNA1/TIMP3/AXIN2/TAB3/TARDBP/PINK1/NUPR1/CST3/DHX9/SLIRP/USP14/ANXA2/RRAGA/DFFA/USP25/PHF23 19 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28/982 412/18722 0.0973122195109611 0.376543425051315 SKP2/GNA12/DDB1/SIAH1/UBR3/KLHL42/WFS1/ANKRD9/DAB2/CEBPA/PSMD1/TBL1X/MDM2/UBE4B/PSMB5/PPP2CB/PLK2/FEM1A/TMUB1/FBXW4/HSP90B1/CD2AP/FBXO22/RAD23B/USP14/FAF2/PSMD6/HUWE1 28 GO:0048017 inositol lipid-mediated signaling 14/982 182/18722 0.0978367229404737 0.378292325320616 PLXNB1/EGFR/PIP5K1A/NF1/ERBB3/IGF1R/FLT1/PTK2/PPARD/CCL5/PDGFA/STAMBP/PIP5K1B/HCST 14 GO:0001754 eye photoreceptor cell differentiation 5/982 47/18722 0.0984928177403792 0.379703279625882 NAGLU/PTN/MYO7A/PRKCI/TUG1 5 GO:0031641 regulation of myelination 5/982 47/18722 0.0984928177403792 0.379703279625882 DAG1/PTN/CYFIP1/TNFRSF21/PARD3 5 GO:0043114 regulation of vascular permeability 5/982 47/18722 0.0984928177403792 0.379703279625882 ADM/TJP1/TJP2/YES1/FERMT2 5 GO:0072583 clathrin-dependent endocytosis 5/982 47/18722 0.0984928177403792 0.379703279625882 DAB2/AP2A2/WASL/FNBP1L/CLTC 5 GO:0006163 purine nucleotide metabolic process 27/982 396/18722 0.0991161409449986 0.38182407028738 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC 27 GO:0040014 regulation of multicellular organism growth 6/982 61/18722 0.0994370861614752 0.382468198067862 ADRB1/APP/GPAM/CHD7/LGMN/AFG3L2 6 GO:0071384 cellular response to corticosteroid stimulus 6/982 61/18722 0.0994370861614752 0.382468198067862 EGFR/ISL1/SERPINF1/ATP2B1/GSTP1/ASS1 6 GO:2000181 negative regulation of blood vessel morphogenesis 12/982 151/18722 0.0995512236361824 0.382468198067862 ADAMTS1/SEMA6A/COL4A2/PPARG/PTN/AMOT/SERPINF1/EPN2/FOXO4/SPARC/PLK2/FOXC1 12 GO:0097581 lamellipodium organization 8/982 90/18722 0.0996499772189847 0.382468198067862 KANK1/FER/CYFIP1/CTTN/NCKAP1/ITGB1/BIN3/VAV3 8 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 8/982 90/18722 0.0996499772189847 0.382468198067862 ADAMTS1/GJA1/GNA12/PPARG/P2RY6/MDM2/GSTP1/DNMT1 8 GO:0031098 stress-activated protein kinase signaling cascade 18/982 247/18722 0.099749296466237 0.382567889976391 EGFR/APP/SEMA4C/DUSP9/TRAF4/MARVELD3/IGF1R/HRAS/PAGE4/HACD3/MAP3K7/PHLPP1/MAP3K13/PINK1/MAP4K4/PRDX1/GSTP1/AKR1B1 18 GO:0040029 regulation of gene expression, epigenetic 9/982 105/18722 0.0999276575639343 0.382970361391243 TFAP2C/HDAC6/SERTAD1/SERTAD2/METTL3/TRIM28/CDCA4/DNMT1/TRIM27 9 GO:0051098 regulation of binding 25/982 363/18722 0.100398243218897 0.383740016618992 MET/LRP1/APP/ISL1/UBASH3B/NRP1/TGFBR3/PPARG/B2M/ZBTB7C/ID1/TMSB4X/DAB2/TRIM6/PTPRF/PHLDA2/ZNF593/PPP2CB/DHX9/PLK2/TRIM28/FOXC1/TCF7L2/ANXA2/NME1 25 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 4/982 34/18722 0.100569900827869 0.383740016618992 CTSV/B2M/CTSL/LGMN 4 GO:0006270 DNA replication initiation 4/982 34/18722 0.100569900827869 0.383740016618992 MCM2/WRNIP1/TOPBP1/CCNE1 4 GO:0035909 aorta morphogenesis 4/982 34/18722 0.100569900827869 0.383740016618992 LRP1/SOX4/CHD7/RBPJ 4 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 4/982 34/18722 0.100569900827869 0.383740016618992 PUM1/ZCCHC3/TSPAN6/PUM2 4 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 4/982 34/18722 0.100569900827869 0.383740016618992 MDM2/ATR/PTTG1IP/KMT5A 4 GO:0043401 steroid hormone mediated signaling pathway 11/982 136/18722 0.101660874466821 0.387619240657119 ESRRG/SKP2/BMP7/ISL1/YAP1/DAB2/HDAC6/ESRRA/PPARD/UBA5/RXRA 11 GO:0006470 protein dephosphorylation 20/982 281/18722 0.103115907278498 0.391220962589694 PTPN14/UBASH3B/PTPRK/SWAP70/PDP2/CAMK2G/CTDSPL/PPP4R1/PTPRF/SLC39A10/PPP1R3E/CPPED1/PPM1H/PHLPP1/PINK1/DUSP6/DUSP5/PPP2CB/DUSP14/HSP90B1 20 GO:0008652 cellular amino acid biosynthetic process 7/982 76/18722 0.103165086954165 0.391220962589694 PLOD2/PSAT1/SLC1A3/CLN3/ASNSD1/AASDHPPT/ASS1 7 GO:0014823 response to activity 7/982 76/18722 0.103165086954165 0.391220962589694 COL4A2/PTN/ALAD/ADSL/PPARD/CYBA/GCLM 7 GO:0045685 regulation of glial cell differentiation 7/982 76/18722 0.103165086954165 0.391220962589694 DAG1/SPINT1/IL6ST/PTN/NF1/TNFRSF21/LDLR 7 GO:0086001 cardiac muscle cell action potential 7/982 76/18722 0.103165086954165 0.391220962589694 GJA1/GJA5/DSG2/DSP/DSC2/PKP2/ANK3 7 GO:0098754 detoxification 12/982 152/18722 0.103230028069943 0.391220962589694 BMP7/ABCG2/MGST3/PTGES/GSTZ1/GPX8/PRDX1/PRDX4/GSTP1/PRDX5/TXNRD2/TXNRD1 12 GO:1901343 negative regulation of vasculature development 12/982 152/18722 0.103230028069943 0.391220962589694 ADAMTS1/SEMA6A/COL4A2/PPARG/PTN/AMOT/SERPINF1/EPN2/FOXO4/SPARC/PLK2/FOXC1 12 GO:0042177 negative regulation of protein catabolic process 10/982 121/18722 0.103355538046127 0.391220962589694 EGFR/MGAT3/ALAD/EFNA1/TIMP3/CST3/USP14/ANXA2/USP25/AZIN1 10 GO:0045931 positive regulation of mitotic cell cycle 10/982 121/18722 0.103355538046127 0.391220962589694 ADAMTS1/PBX1/EGFR/APP/BRD4/MTA3/CCND1/MDM2/LGMN/BRCA2 10 GO:1904019 epithelial cell apoptotic process 10/982 121/18722 0.103355538046127 0.391220962589694 YAP1/WFS1/PRKCI/KRT18/NUPR1/GSN/TCF7L2/KRT8/BAD/PDPK1 10 GO:0050870 positive regulation of T cell activation 16/982 216/18722 0.104051597960879 0.392802939689605 SOX4/TFRC/IL6ST/GPAM/B2M/CD46/HLA-A/GLI3/YES1/CD24/HLA-E/CCL5/DPP4/FLOT2/BAD/BCL10 16 GO:0031647 regulation of protein stability 21/982 298/18722 0.104390646904887 0.392802939689605 PLPP3/SOX4/DVL3/SIAH1/WFS1/EFNA1/RNF128/USP27X/TARDBP/TBL1X/HDAC6/MDM2/TRIM24/PINK1/LMNA/GRN/USP47/GSN/FLOT2/DDOST/BAG1 21 GO:0072522 purine-containing compound biosynthetic process 15/982 200/18722 0.104427122552444 0.392802939689605 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/SLC25A1/PINK1/SLC35B2/NME4/PPAT/IMPDH2/HSD17B12/ADK/NME1/ATIC 15 GO:0055001 muscle cell development 14/982 184/18722 0.104478265930505 0.392802939689605 OBSL1/ISL1/PARP2/ADM/ACTN1/MYOF/CSRP2/TBX3/LMNA/ITGB1/BIN3/AFG3L2/FBXO22/KRT8 14 GO:0006354 DNA-templated transcription, elongation 8/982 91/18722 0.104532906814208 0.392802939689605 BRD4/ELL/SERTAD1/SERTAD2/WDR43/CDCA4/ZNF326/ENY2 8 GO:0051492 regulation of stress fiber assembly 8/982 91/18722 0.104532906814208 0.392802939689605 MET/TACSTD2/NRP1/PPP1R9A/TJP1/FERMT2/PPFIA1/F11R 8 GO:0060191 regulation of lipase activity 8/982 91/18722 0.104532906814208 0.392802939689605 EGFR/LRP1/FGFR2/FLT1/HRAS/P2RY6/CCL5/PDPK1 8 GO:1990874 vascular associated smooth muscle cell proliferation 8/982 91/18722 0.104532906814208 0.392802939689605 ADAMTS1/GJA1/GNA12/PPARG/P2RY6/MDM2/GSTP1/DNMT1 8 GO:0045926 negative regulation of growth 18/982 249/18722 0.105464177052984 0.392802939689605 GJA1/SEMA6D/SEMA6A/SLC6A4/ADRB1/SH3BP4/NRP1/WWC1/DCBLD2/SEMA3F/SERTAD3/SEMA4C/SMARCA2/WWC3/PPARD/LGMN/SERTAD2/VGLL4 18 GO:1901988 negative regulation of cell cycle phase transition 18/982 249/18722 0.105464177052984 0.392802939689605 SOX4/WEE1/EIF2AK4/CENPF/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/GTSE1/USP47/LCMT1 18 GO:0032527 protein exit from endoplasmic reticulum 5/982 48/18722 0.105468712983798 0.392802939689605 TMEM30B/TM9SF4/INSIG1/HSP90B1/FAF2 5 GO:0045839 negative regulation of mitotic nuclear division 5/982 48/18722 0.105468712983798 0.392802939689605 BMP7/CENPF/ZWINT/SPDL1/LCMT1 5 GO:0048146 positive regulation of fibroblast proliferation 5/982 48/18722 0.105468712983798 0.392802939689605 PDGFA/CDK6/DHX9/ANXA2/CCNA2 5 GO:0009116 nucleoside metabolic process 6/982 62/18722 0.1054934829979 0.392802939689605 TK1/NME4/PPAT/DTYMK/ADK/ATIC 6 GO:0009311 oligosaccharide metabolic process 6/982 62/18722 0.1054934829979 0.392802939689605 MOGS/GAA/FUT8/MANBA/ST3GAL6/NEU1 6 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 6/982 62/18722 0.1054934829979 0.392802939689605 DAG1/HRAS/NSG1/PRKCI/EPS8/FLOT2 6 GO:0050671 positive regulation of lymphocyte proliferation 11/982 137/18722 0.105610514222158 0.392802939689605 TFRC/IL6ST/GPAM/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2 11 GO:0006359 regulation of transcription by RNA polymerase III 3/982 22/18722 0.10565615881605 0.392802939689605 CEBPA/ELL/PRDX5 3 GO:0016137 glycoside metabolic process 3/982 22/18722 0.10565615881605 0.392802939689605 FUCA1/AKR1B1/GUSB 3 GO:0035024 negative regulation of Rho protein signal transduction 3/982 22/18722 0.10565615881605 0.392802939689605 KANK1/MET/ITGB1 3 GO:0036120 cellular response to platelet-derived growth factor stimulus 3/982 22/18722 0.10565615881605 0.392802939689605 PTN/YES1/CCNA2 3 GO:0060444 branching involved in mammary gland duct morphogenesis 3/982 22/18722 0.10565615881605 0.392802939689605 LRP5/KDM5B/TBX3 3 GO:0060965 negative regulation of gene silencing by miRNA 3/982 22/18722 0.10565615881605 0.392802939689605 KCNQ1OT1/LIN28B/PPARG 3 GO:0071359 cellular response to dsRNA 3/982 22/18722 0.10565615881605 0.392802939689605 COLEC12/ZCCHC3/DHX9 3 GO:0071404 cellular response to low-density lipoprotein particle stimulus 3/982 22/18722 0.10565615881605 0.392802939689605 PPARG/LDLR/ITGB1 3 GO:0002688 regulation of leukocyte chemotaxis 10/982 122/18722 0.107611840477649 0.395152949979087 SWAP70/PTN/JAM3/PTK2/CCL5/MPP1/LGMN/DPP4/CREB3/PGF 10 GO:0072329 monocarboxylic acid catabolic process 10/982 122/18722 0.107611840477649 0.395152949979087 SLC27A2/ACADS/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/HADHB 10 GO:0009952 anterior/posterior pattern specification 15/982 201/18722 0.107697840614709 0.395152949979087 NR2F2/PBX1/WLS/LRP5/BHLHE41/COBL/PGAP1/ACVR2B/LRP6/GLI3/AXIN2/BASP1/TBX3/FOXC1/RBPJ 15 GO:0006275 regulation of DNA replication 9/982 107/18722 0.109029116959735 0.395152949979087 EGFR/CHTF8/HRAS/WRNIP1/BCAR3/ATR/DHX9/BRCA2/CCNA2 9 GO:0010765 positive regulation of sodium ion transport 4/982 35/18722 0.109089810098 0.395152949979087 WNK2/PRSS8/PKP2/ANK3 4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 4/982 35/18722 0.109089810098 0.395152949979087 SKP2/ISL1/YAP1/UBA5 4 GO:0033280 response to vitamin D 4/982 35/18722 0.109089810098 0.395152949979087 BMP7/PTN/ATP2B1/TRIM24 4 GO:0034331 cell junction maintenance 4/982 35/18722 0.109089810098 0.395152949979087 TJP1/FERMT2/KIFC3/MTSS1 4 GO:0042462 eye photoreceptor cell development 4/982 35/18722 0.109089810098 0.395152949979087 NAGLU/MYO7A/PRKCI/TUG1 4 GO:0086005 ventricular cardiac muscle cell action potential 4/982 35/18722 0.109089810098 0.395152949979087 DSG2/DSP/DSC2/PKP2 4 GO:0098801 regulation of renal system process 4/982 35/18722 0.109089810098 0.395152949979087 GJA1/GJA5/COMT/CYBA 4 GO:0001708 cell fate specification 8/982 92/18722 0.109546202496213 0.395152949979087 ISL1/NRP1/ESRP1/GLI3/LMO4/TBX3/ITGB1/RBPJ 8 GO:0032273 positive regulation of protein polymerization 11/982 138/18722 0.109648546242358 0.395152949979087 MET/SCIN/FER/CYFIP1/CTTN/NCKAP1/WASL/PINK1/GSN/RICTOR/TRIM27 11 GO:0032946 positive regulation of mononuclear cell proliferation 11/982 138/18722 0.109648546242358 0.395152949979087 TFRC/IL6ST/GPAM/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2 11 GO:0055076 transition metal ion homeostasis 11/982 138/18722 0.109648546242358 0.395152949979087 APP/TFRC/ACO1/EPAS1/B2M/ANKRD9/SLC39A10/SLC40A1/SLC11A2/SLC39A7/SCO1 11 GO:0042692 muscle cell differentiation 26/982 384/18722 0.110236812126519 0.395152949979087 OBSL1/BHLHE41/FGFR2/ISL1/PARP2/MMP14/SEMA4C/ERVW-1/ADM/FOXO4/ACTN1/MYOF/CSRP2/TBX3/MORF4L2/MDM2/LMNA/ITGB1/BIN3/AFG3L2/CBY1/DNMT1/FBXO22/KRT8/KLF5/RBPJ 26 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 2/982 11/18722 0.110454946524062 0.395152949979087 RTCB/DDX1 2 GO:0001967 suckling behavior 2/982 11/18722 0.110454946524062 0.395152949979087 APP/UBR3 2 GO:0006020 inositol metabolic process 2/982 11/18722 0.110454946524062 0.395152949979087 ISYNA1/SLC5A3 2 GO:0007042 lysosomal lumen acidification 2/982 11/18722 0.110454946524062 0.395152949979087 CLN3/GRN 2 GO:0009120 deoxyribonucleoside metabolic process 2/982 11/18722 0.110454946524062 0.395152949979087 TK1/DTYMK 2 GO:0009313 oligosaccharide catabolic process 2/982 11/18722 0.110454946524062 0.395152949979087 MANBA/NEU1 2 GO:0010887 negative regulation of cholesterol storage 2/982 11/18722 0.110454946524062 0.395152949979087 PPARG/PPARD 2 GO:0015810 aspartate transmembrane transport 2/982 11/18722 0.110454946524062 0.395152949979087 SLC25A13/LRRC8D 2 GO:0030210 heparin biosynthetic process 2/982 11/18722 0.110454946524062 0.395152949979087 GLCE/EXT2 2 GO:0032329 serine transport 2/982 11/18722 0.110454946524062 0.395152949979087 SLC1A5/SLC38A2 2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 2/982 11/18722 0.110454946524062 0.395152949979087 SKP2/YAP1 2 GO:0033197 response to vitamin E 2/982 11/18722 0.110454946524062 0.395152949979087 ALAD/CCND1 2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2/982 11/18722 0.110454946524062 0.395152949979087 ACADS/ACADVL 2 GO:0033625 positive regulation of integrin activation 2/982 11/18722 0.110454946524062 0.395152949979087 FERMT1/FERMT2 2 GO:0033690 positive regulation of osteoblast proliferation 2/982 11/18722 0.110454946524062 0.395152949979087 ITGAV/LRP5 2 GO:0034975 protein folding in endoplasmic reticulum 2/982 11/18722 0.110454946524062 0.395152949979087 P4HB/HSP90B1 2 GO:0043589 skin morphogenesis 2/982 11/18722 0.110454946524062 0.395152949979087 ITGB4/ITGA6 2 GO:0045654 positive regulation of megakaryocyte differentiation 2/982 11/18722 0.110454946524062 0.395152949979087 SCIN/RCOR1 2 GO:0045945 positive regulation of transcription by RNA polymerase III 2/982 11/18722 0.110454946524062 0.395152949979087 CEBPA/ELL 2 GO:0046710 GDP metabolic process 2/982 11/18722 0.110454946524062 0.395152949979087 TJP2/MPP1 2 GO:0051657 maintenance of organelle location 2/982 11/18722 0.110454946524062 0.395152949979087 ASPM/ARHGAP21 2 GO:0060174 limb bud formation 2/982 11/18722 0.110454946524062 0.395152949979087 FGFR2/SOX4 2 GO:0060379 cardiac muscle cell myoblast differentiation 2/982 11/18722 0.110454946524062 0.395152949979087 ISL1/RBPJ 2 GO:0060742 epithelial cell differentiation involved in prostate gland development 2/982 11/18722 0.110454946524062 0.395152949979087 FGFR2/PSAP 2 GO:0060837 blood vessel endothelial cell differentiation 2/982 11/18722 0.110454946524062 0.395152949979087 NRP1/RBPJ 2 GO:0061314 Notch signaling involved in heart development 2/982 11/18722 0.110454946524062 0.395152949979087 GALNT11/RBPJ 2 GO:0071492 cellular response to UV-A 2/982 11/18722 0.110454946524062 0.395152949979087 MME/OPN3 2 GO:0072205 metanephric collecting duct development 2/982 11/18722 0.110454946524062 0.395152949979087 DLG5/AKR1B1 2 GO:0090160 Golgi to lysosome transport 2/982 11/18722 0.110454946524062 0.395152949979087 CLN3/EHD3 2 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 2/982 11/18722 0.110454946524062 0.395152949979087 DVL3/NPHP3 2 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 2/982 11/18722 0.110454946524062 0.395152949979087 TRIM28/DNMT1 2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 2/982 11/18722 0.110454946524062 0.395152949979087 SLC35B4/SLC35D1 2 GO:0097050 type B pancreatic cell apoptotic process 2/982 11/18722 0.110454946524062 0.395152949979087 WFS1/TCF7L2 2 GO:0106049 regulation of cellular response to osmotic stress 2/982 11/18722 0.110454946524062 0.395152949979087 CLN3/BAD 2 GO:0140042 lipid droplet formation 2/982 11/18722 0.110454946524062 0.395152949979087 CDS1/SQLE 2 GO:1900426 positive regulation of defense response to bacterium 2/982 11/18722 0.110454946524062 0.395152949979087 CYBA/GRN 2 GO:1902337 regulation of apoptotic process involved in morphogenesis 2/982 11/18722 0.110454946524062 0.395152949979087 BMP7/FOXC1 2 GO:1903299 regulation of hexokinase activity 2/982 11/18722 0.110454946524062 0.395152949979087 RANBP2/BAD 2 GO:1903961 positive regulation of anion transmembrane transport 2/982 11/18722 0.110454946524062 0.395152949979087 TCAF1/ITGB1 2 GO:0010506 regulation of autophagy 22/982 317/18722 0.110660698370818 0.395617685196839 MET/SH3BP4/TRIML2/ATP6V1B1/CTTN/TRIM6/TFEB/SLC25A4/MAP3K7/TAB3/CLN3/HDAC6/PINK1/NUPR1/ATP6V1H/PSAP/PLK2/ATP6V1C2/TRIM27/BAD/RRAGA/PHF23 22 GO:0030856 regulation of epithelial cell differentiation 12/982 154/18722 0.110826939526133 0.395940627786515 YAP1/ID1/ESRP1/CCND1/CD24/MAFG/NCOA3/TBX3/AHI1/FOXC1/BAD/F11R 12 GO:0008217 regulation of blood pressure 14/982 186/18722 0.111385901509811 0.397665203473769 GJA1/ENPEP/NR2F2/ADRB1/LRP5/GJA5/MME/PPARG/ADM/ATP2B1/NAV2/CYBA/EXT2/F11R 14 GO:0032233 positive regulation of actin filament bundle assembly 6/982 63/18722 0.111736579162538 0.398644320733104 NRP1/SWAP70/SYNPO/ID1/FERMT2/MTSS1 6 GO:0009409 response to cold 5/982 49/18722 0.112680631438593 0.400096782562085 ADRB1/EIF2AK4/ADM/ATP2B1/ACADVL 5 GO:0035088 establishment or maintenance of apical/basal cell polarity 5/982 49/18722 0.112680631438593 0.400096782562085 DLG5/FAT1/PRKCI/PARD3/CLIC4 5 GO:0042461 photoreceptor cell development 5/982 49/18722 0.112680631438593 0.400096782562085 NAGLU/MYO7A/PRKCI/AHI1/TUG1 5 GO:0061245 establishment or maintenance of bipolar cell polarity 5/982 49/18722 0.112680631438593 0.400096782562085 DLG5/FAT1/PRKCI/PARD3/CLIC4 5 GO:0070741 response to interleukin-6 5/982 49/18722 0.112680631438593 0.400096782562085 YAP1/IL6ST/FER/CEBPA/ST3GAL6 5 GO:0070849 response to epidermal growth factor 5/982 49/18722 0.112680631438593 0.400096782562085 EGFR/ID1/GSTP1/FOXC1/PDPK1 5 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 5/982 49/18722 0.112680631438593 0.400096782562085 ADAMTS1/GJA1/P2RY6/MDM2/DNMT1 5 GO:2001020 regulation of response to DNA damage stimulus 16/982 219/18722 0.1136176968616 0.403149596483067 EGFR/POLQ/BRCC3/AXIN2/WRNIP1/MDM2/TRIAP1/RMI2/MAGEF1/ATR/DHX9/WDR48/USP47/PTTG1IP/TRIM28/KMT5A 16 GO:0007173 epidermal growth factor receptor signaling pathway 9/982 108/18722 0.113748268987083 0.403157758834727 EGFR/EFEMP1/KIF16B/FER/GAB1/PTK2/IFI6/BCAR3/PDPK1 9 GO:0030216 keratinocyte differentiation 11/982 139/18722 0.113774582247837 0.403157758834727 PIP5K1A/DSP/YAP1/EXPH5/NCOA3/IFT74/FLNB/FOXC1/OPN3/CLIC4/RBPJ 11 GO:0009064 glutamine family amino acid metabolic process 7/982 78/18722 0.114297333052274 0.403912526558714 CLN3/GFPT1/RIMKLB/ASNSD1/PPAT/GCLM/ASS1 7 GO:0030500 regulation of bone mineralization 7/982 78/18722 0.114297333052274 0.403912526558714 FBN2/BMP7/PTN/NOTUM/ACVR2B/ATP2B1/TFAP2A 7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 7/982 78/18722 0.114297333052274 0.403912526558714 DHCR24/IFI6/MDM2/TRIAP1/USP47/BIRC5/PRDX5 7 GO:0070373 negative regulation of ERK1 and ERK2 cascade 7/982 78/18722 0.114297333052274 0.403912526558714 SEMA6A/WNK2/FBLN1/DUSP9/TIMP3/DUSP6/GSTP1 7 GO:0106027 neuron projection organization 8/982 93/18722 0.114688671548441 0.404396885274536 APP/PPP1R9A/CTTN/IGF1R/EFNA1/WASL/HDAC6/LGMN 8 GO:1901992 positive regulation of mitotic cell cycle phase transition 8/982 93/18722 0.114688671548441 0.404396885274536 ADAMTS1/PBX1/EGFR/APP/BRD4/MTA3/CCND1/MDM2 8 GO:1902807 negative regulation of cell cycle G1/S phase transition 8/982 93/18722 0.114688671548441 0.404396885274536 SOX4/WEE1/CTDSPL/CCND1/MDM2/TRIAP1/PLK2/GTSE1 8 GO:0034614 cellular response to reactive oxygen species 12/982 155/18722 0.114744514993542 0.404396885274536 NET1/EGFR/MET/BMP7/PAWR/PTPRK/FER/HDAC6/MDM2/PINK1/PRDX1/PRDX5 12 GO:0033044 regulation of chromosome organization 14/982 187/18722 0.114939169231562 0.404536239346713 CENPF/MCM2/AXIN2/ZWINT/SPDL1/FEN1/RMI2/PKIB/TOP2A/ATR/TRIM28/DNMT1/LCMT1/RAD50 14 GO:0061136 regulation of proteasomal protein catabolic process 14/982 187/18722 0.114939169231562 0.404536239346713 GNA12/TMTC3/ALAD/DAB2/CEBPA/MDM2/PINK1/NUPR1/PLK2/PSME3/FBXO22/RAD23B/USP14/USP25 14 GO:0046395 carboxylic acid catabolic process 17/982 236/18722 0.115748189364141 0.405770239471249 GLDC/SLC27A2/ACADS/ECI1/GSTZ1/QPRT/PPARD/ACADVL/SLC25A17/DECR2/PPAT/ECHDC2/IRS2/GCSH/CDO1/ENOSF1/HADHB 17 GO:0010508 positive regulation of autophagy 10/982 124/18722 0.116420412597652 0.405770239471249 SH3BP4/TRIML2/TRIM6/TFEB/SLC25A4/MAP3K7/PINK1/PLK2/TRIM27/BAD 10 GO:0001919 regulation of receptor recycling 3/982 23/18722 0.117001234694164 0.405770239471249 KIF16B/NSG1/ANXA2 3 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3/982 23/18722 0.117001234694164 0.405770239471249 ENPEP/MME/CYBA 3 GO:0003323 type B pancreatic cell development 3/982 23/18722 0.117001234694164 0.405770239471249 CDK6/BAD/PDPK1 3 GO:0006541 glutamine metabolic process 3/982 23/18722 0.117001234694164 0.405770239471249 GFPT1/ASNSD1/PPAT 3 GO:0006929 substrate-dependent cell migration 3/982 23/18722 0.117001234694164 0.405770239471249 NRP1/CTTN/CD2AP 3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 3/982 23/18722 0.117001234694164 0.405770239471249 CLDN4/CLDN19/CLDN7 3 GO:0021871 forebrain regionalization 3/982 23/18722 0.117001234694164 0.405770239471249 PGAP1/ADGRG1/GLI3 3 GO:0021884 forebrain neuron development 3/982 23/18722 0.117001234694164 0.405770239471249 NRP2/FGFR2/NRP1 3 GO:0030539 male genitalia development 3/982 23/18722 0.117001234694164 0.405770239471249 LGR4/DHCR24/TBX3 3 GO:0031338 regulation of vesicle fusion 3/982 23/18722 0.117001234694164 0.405770239471249 ANKRD27/TBC1D4/ANXA2 3 GO:0045662 negative regulation of myoblast differentiation 3/982 23/18722 0.117001234694164 0.405770239471249 MBNL3/PPARD/TBX3 3 GO:0051383 kinetochore organization 3/982 23/18722 0.117001234694164 0.405770239471249 CENPF/SMC2/CENPW 3 GO:0051904 pigment granule transport 3/982 23/18722 0.117001234694164 0.405770239471249 MYO7A/MREG/RAB17 3 GO:0060384 innervation 3/982 23/18722 0.117001234694164 0.405770239471249 ISL1/NRP1/CHD7 3 GO:0060487 lung epithelial cell differentiation 3/982 23/18722 0.117001234694164 0.405770239471249 YAP1/NFIB/RBPJ 3 GO:0060575 intestinal epithelial cell differentiation 3/982 23/18722 0.117001234694164 0.405770239471249 YAP1/IL6ST/KLF5 3 GO:0071305 cellular response to vitamin D 3/982 23/18722 0.117001234694164 0.405770239471249 PTN/ATP2B1/TRIM24 3 GO:0071636 positive regulation of transforming growth factor beta production 3/982 23/18722 0.117001234694164 0.405770239471249 CD200/FERMT1/CD46 3 GO:2000737 negative regulation of stem cell differentiation 3/982 23/18722 0.117001234694164 0.405770239471249 YAP1/TRIM6/YTHDF2 3 GO:2000810 regulation of bicellular tight junction assembly 3/982 23/18722 0.117001234694164 0.405770239471249 GJA1/TJP1/F11R 3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 4/982 36/18722 0.117920761368044 0.406020459201508 CTSV/B2M/CTSL/LGMN 4 GO:0045746 negative regulation of Notch signaling pathway 4/982 36/18722 0.117920761368044 0.406020459201508 BMP7/MMP14/YTHDF2/METTL3 4 GO:0060251 regulation of glial cell proliferation 4/982 36/18722 0.117920761368044 0.406020459201508 EGFR/ETV5/PTN/PRKCI 4 GO:0070670 response to interleukin-4 4/982 36/18722 0.117920761368044 0.406020459201508 ALAD/MCM2/IMPDH2/IL2RG 4 GO:0070873 regulation of glycogen metabolic process 4/982 36/18722 0.117920761368044 0.406020459201508 SORBS1/PHLDA2/PPP1R3E/IRS2 4 GO:0090313 regulation of protein targeting to membrane 4/982 36/18722 0.117920761368044 0.406020459201508 TCAF1/MIEF1/HRAS/ANK3 4 GO:0090322 regulation of superoxide metabolic process 4/982 36/18722 0.117920761368044 0.406020459201508 EGFR/BMP7/CYBA/GSTP1 4 GO:0006749 glutathione metabolic process 6/982 64/18722 0.11816316278142 0.406020459201508 GSS/GSTZ1/IDH1/GSTP1/GCLM/GSTA4 6 GO:0030888 regulation of B cell proliferation 6/982 64/18722 0.11816316278142 0.406020459201508 TFRC/PAWR/TNFRSF21/SLC39A10/VAV3/IRS2 6 GO:0045995 regulation of embryonic development 6/982 64/18722 0.11816316278142 0.406020459201508 DAG1/LAMA5/AMOT/PHLDA2/RACGAP1/NPHP3 6 GO:0046530 photoreceptor cell differentiation 6/982 64/18722 0.11816316278142 0.406020459201508 NAGLU/PTN/MYO7A/PRKCI/AHI1/TUG1 6 GO:0046579 positive regulation of Ras protein signal transduction 6/982 64/18722 0.11816316278142 0.406020459201508 NET1/ADGRG1/ALS2/HRAS/MAP4K4/F11R 6 GO:0046854 phosphatidylinositol phosphate biosynthetic process 6/982 64/18722 0.11816316278142 0.406020459201508 PIP5K1A/SOCS6/TMEM150A/SOCS7/SYNJ1/PIP5K1B 6 GO:0070542 response to fatty acid 6/982 64/18722 0.11816316278142 0.406020459201508 GLDC/ALAD/LDLR/BAD/NME1/ASS1 6 GO:0035051 cardiocyte differentiation 12/982 156/18722 0.11874104864438 0.407737531092223 EGFR/OBSL1/BMP7/ISL1/PARP2/TGFBR3/FOLR1/TBX3/LMNA/ITGB1/CBY1/RBPJ 12 GO:0031334 positive regulation of protein-containing complex assembly 17/982 237/18722 0.118962945910145 0.408230740702181 MET/SCIN/TFRC/FERMT1/FER/CYFIP1/CTTN/NCKAP1/WASL/MPP7/FERMT2/PINK1/ATR/CAND1/GSN/RICTOR/TRIM27 17 GO:0019080 viral gene expression 8/982 94/18722 0.119958959729964 0.41032099337762 MOGS/EIF2AK4/FUT8/TARDBP/CCL5/DHX9/TRIM27/TAF11 8 GO:0048704 embryonic skeletal system morphogenesis 8/982 94/18722 0.119958959729964 0.41032099337762 FGFR2/BMP7/MMP14/RDH10/TFAP2A/GLI3/SLC39A1/SLC39A3 8 GO:0032272 negative regulation of protein polymerization 7/982 79/18722 0.120090289356583 0.41032099337762 KANK1/KANK4/SCIN/TMSB4X/TRIOBP/EPS8/GSN 7 GO:0019083 viral transcription 5/982 50/18722 0.120122729464652 0.41032099337762 TARDBP/CCL5/DHX9/TRIM27/TAF11 5 GO:0038093 Fc receptor signaling pathway 5/982 50/18722 0.120122729464652 0.41032099337762 FER/YES1/PTK2/MAP3K7/VAV3 5 GO:1904036 negative regulation of epithelial cell apoptotic process 5/982 50/18722 0.120122729464652 0.41032099337762 YAP1/WFS1/NUPR1/TCF7L2/PDPK1 5 GO:2000677 regulation of transcription regulatory region DNA binding 5/982 50/18722 0.120122729464652 0.41032099337762 ZBTB7C/TMSB4X/TRIM6/ZNF593/FOXC1 5 GO:0009165 nucleotide biosynthetic process 18/982 254/18722 0.120621567139439 0.411755297250861 SLC26A2/ACSS1/SLC25A13/TMSB4X/ADSL/QPRT/SLC25A1/PINK1/SLC35B2/NME4/PPAT/DTYMK/IMPDH2/HSD17B12/ADK/NME1/ATIC/RRM1 18 GO:0035296 regulation of tube diameter 11/982 141/18722 0.122288741083477 0.413861301273793 GJA1/EGFR/SLC6A4/ADRB1/GJA5/ADM/ATP2B1/PPARD/EXT2/GCLM/FOXC1 11 GO:0050921 positive regulation of chemotaxis 11/982 141/18722 0.122288741083477 0.413861301273793 MET/TPBG/NRP1/SWAP70/PTN/TMSB4X/PTK2/CCL5/LGMN/CREB3/PGF 11 GO:0097746 blood vessel diameter maintenance 11/982 141/18722 0.122288741083477 0.413861301273793 GJA1/EGFR/SLC6A4/ADRB1/GJA5/ADM/ATP2B1/PPARD/EXT2/GCLM/FOXC1 11 GO:1990845 adaptive thermogenesis 12/982 157/18722 0.122816124312823 0.413861301273793 GJA1/LGR4/ESRRG/PRLR/ADRB1/EPAS1/ACVR2B/ID1/IGF1R/SLC25A4/FH/RBPJ 12 GO:0034599 cellular response to oxidative stress 20/982 288/18722 0.123003084933274 0.413861301273793 NET1/EGFR/MET/MGAT3/BMP7/ETV5/PAWR/PTPRK/EPAS1/FER/FUT8/PAGE4/NFE2L1/HDAC6/P4HB/GPX8/MDM2/PINK1/PRDX1/PRDX5 20 GO:0000302 response to reactive oxygen species 16/982 222/18722 0.123694292452086 0.413861301273793 NET1/EGFR/MET/BMP7/PAWR/PTPRK/FER/HDAC6/MDM2/PINK1/PRDX1/PPP2CB/GSTP1/PRDX5/TXNRD2/BAD 16 GO:0033692 cellular polysaccharide biosynthetic process 6/982 65/18722 0.124769708162183 0.413861301273793 SORBS1/AGL/B3GNT3/PPP1R3E/IRS2/EXT2 6 GO:0060389 pathway-restricted SMAD protein phosphorylation 6/982 65/18722 0.124769708162183 0.413861301273793 LRP1/BMP7/TGFBR3/PPARG/RBPMS/DAB2 6 GO:1905330 regulation of morphogenesis of an epithelium 6/982 65/18722 0.124769708162183 0.413861301273793 GJA1/LGR4/TACSTD2/BMP7/MAGED1/PDGFA 6 GO:0008016 regulation of heart contraction 15/982 206/18722 0.124968252909601 0.413861301273793 GJA1/ADRB1/GJA5/DSG2/DSP/ISL1/DSC2/GAA/EPAS1/ADM/ATP2B1/CYP2J2/MDM2/PKP2/EHD3 15 GO:1901987 regulation of cell cycle phase transition 26/982 390/18722 0.125198719954045 0.413861301273793 ADAMTS1/PBX1/EGFR/APP/SOX4/WEE1/EIF2AK4/DDB1/BRD4/CENPF/MTA3/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/ATR/PLK2/TOPBP1/PSME3/GTSE1/USP47/LCMT1 26 GO:0042982 amyloid precursor protein metabolic process 8/982 95/18722 0.125355555110001 0.413861301273793 PAWR/NSG1/EFNA1/DHCR24/CLN3/FLOT2/BACE2/ITM2C 8 GO:0051403 stress-activated MAPK cascade 17/982 239/18722 0.125550608144649 0.413861301273793 EGFR/APP/SEMA4C/DUSP9/TRAF4/MARVELD3/IGF1R/HRAS/PAGE4/HACD3/MAP3K7/PHLPP1/MAP3K13/PINK1/MAP4K4/PRDX1/GSTP1 17 GO:1903039 positive regulation of leukocyte cell-cell adhesion 17/982 239/18722 0.125550608144649 0.413861301273793 SOX4/TFRC/IL6ST/GPAM/B2M/CD46/HLA-A/NFAT5/GLI3/YES1/CD24/HLA-E/CCL5/DPP4/FLOT2/BAD/BCL10 17 GO:0051216 cartilage development 14/982 190/18722 0.125994168181468 0.413861301273793 BMP7/SCIN/SERPINH1/EFEMP1/NFIB/ITGB8/TSKU/GLI3/AXIN2/ESRRA/CREB3L2/GLG1/SMAD5/TRIP11 14 GO:0001570 vasculogenesis 7/982 80/18722 0.126031515382714 0.413861301273793 ITGAV/YAP1/RASA1/TGFBR3/ITGB8/AMOT/ADM 7 GO:0009791 post-embryonic development 7/982 80/18722 0.126031515382714 0.413861301273793 FBN1/FGFR2/KDM5B/EFEMP1/ACO1/MYO7A/INPPL1 7 GO:0035150 regulation of tube size 11/982 142/18722 0.126675717378235 0.413861301273793 GJA1/EGFR/SLC6A4/ADRB1/GJA5/ADM/ATP2B1/PPARD/EXT2/GCLM/FOXC1 11 GO:2000045 regulation of G1/S transition of mitotic cell cycle 11/982 142/18722 0.126675717378235 0.413861301273793 ADAMTS1/EGFR/SOX4/WEE1/CTDSPL/CCND1/MDM2/TRIAP1/PLK2/PSME3/GTSE1 11 GO:0001659 temperature homeostasis 13/982 174/18722 0.126695385815132 0.413861301273793 GJA1/LGR4/ESRRG/PRLR/ADRB1/EPAS1/ACVR2B/ID1/IGF1R/PTGES/ACADVL/FH/RBPJ 13 GO:0048639 positive regulation of developmental growth 13/982 174/18722 0.126695385815132 0.413861301273793 LRP1/FGFR2/PARP2/YAP1/NRP1/TGFBR3/GPAM/CHD7/CYFIP1/BASP1/PPARD/MAP3K13/RBPJ 13 GO:0032570 response to progesterone 4/982 37/18722 0.127050308141415 0.413861301273793 YAP1/CLDN4/PTN/BAD 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/982 37/18722 0.127050308141415 0.413861301273793 SORBS1/PPP1R3E/CLTC/IRS2 4 GO:0043403 skeletal muscle tissue regeneration 4/982 37/18722 0.127050308141415 0.413861301273793 DAG1/PPARD/BIN3/KLF5 4 GO:0045730 respiratory burst 4/982 37/18722 0.127050308141415 0.413861301273793 CD24/CYBA/CD52/GRN 4 GO:0060428 lung epithelium development 4/982 37/18722 0.127050308141415 0.413861301273793 FGFR2/YAP1/NFIB/RBPJ 4 GO:0010656 negative regulation of muscle cell apoptotic process 5/982 51/18722 0.127788702496296 0.413861301273793 BMP7/LRP6/NUPR1/DNMT1/PDPK1 5 GO:0014009 glial cell proliferation 5/982 51/18722 0.127788702496296 0.413861301273793 EGFR/ETV5/SOX4/PTN/PRKCI 5 GO:0032964 collagen biosynthetic process 5/982 51/18722 0.127788702496296 0.413861301273793 SERPINH1/TRAM2/P3H4/PPARD/VIM 5 GO:0045668 negative regulation of osteoblast differentiation 5/982 51/18722 0.127788702496296 0.413861301273793 LRP5/PPARG/AXIN2/CRIM1/CDK6 5 GO:0046850 regulation of bone remodeling 5/982 51/18722 0.127788702496296 0.413861301273793 EGFR/SYT7/TFRC/UBASH3B/NF1 5 GO:0071622 regulation of granulocyte chemotaxis 5/982 51/18722 0.127788702496296 0.413861301273793 JAM3/PTK2/CCL5/MPP1/DPP4 5 GO:0002664 regulation of T cell tolerance induction 2/982 12/18722 0.12811174316898 0.413861301273793 HLA-B/PHLPP1 2 GO:0006703 estrogen biosynthetic process 2/982 12/18722 0.12811174316898 0.413861301273793 HSD17B1/HSD17B12 2 GO:0007614 short-term memory 2/982 12/18722 0.12811174316898 0.413861301273793 SERPINF1/COMT 2 GO:0009265 2'-deoxyribonucleotide biosynthetic process 2/982 12/18722 0.12811174316898 0.413861301273793 DTYMK/ADK 2 GO:0010587 miRNA catabolic process 2/982 12/18722 0.12811174316898 0.413861301273793 KCNQ1OT1/LIN28B 2 GO:0015780 nucleotide-sugar transmembrane transport 2/982 12/18722 0.12811174316898 0.413861301273793 SLC35B4/SLC35D1 2 GO:0019627 urea metabolic process 2/982 12/18722 0.12811174316898 0.413861301273793 CEBPA/ASS1 2 GO:0021670 lateral ventricle development 2/982 12/18722 0.12811174316898 0.413861301273793 TSKU/CDK6 2 GO:0030202 heparin metabolic process 2/982 12/18722 0.12811174316898 0.413861301273793 GLCE/EXT2 2 GO:0031453 positive regulation of heterochromatin assembly 2/982 12/18722 0.12811174316898 0.413861301273793 TRIM28/DNMT1 2 GO:0032908 regulation of transforming growth factor beta1 production 2/982 12/18722 0.12811174316898 0.413861301273793 TSKU/CD2AP 2 GO:0033629 negative regulation of cell adhesion mediated by integrin 2/982 12/18722 0.12811174316898 0.413861301273793 SWAP70/JAM3 2 GO:0034333 adherens junction assembly 2/982 12/18722 0.12811174316898 0.413861301273793 DLG5/JAM3 2 GO:0034392 negative regulation of smooth muscle cell apoptotic process 2/982 12/18722 0.12811174316898 0.413861301273793 LRP6/DNMT1 2 GO:0038203 TORC2 signaling 2/982 12/18722 0.12811174316898 0.413861301273793 PINK1/RICTOR 2 GO:0043476 pigment accumulation 2/982 12/18722 0.12811174316898 0.413861301273793 ANKRD27/RAB38 2 GO:0043482 cellular pigment accumulation 2/982 12/18722 0.12811174316898 0.413861301273793 ANKRD27/RAB38 2 GO:0043696 dedifferentiation 2/982 12/18722 0.12811174316898 0.413861301273793 NCOA3/CDK6 2 GO:0043697 cell dedifferentiation 2/982 12/18722 0.12811174316898 0.413861301273793 NCOA3/CDK6 2 GO:0045916 negative regulation of complement activation 2/982 12/18722 0.12811174316898 0.413861301273793 CD46/CD59 2 GO:0046051 UTP metabolic process 2/982 12/18722 0.12811174316898 0.413861301273793 NME4/NME1 2 GO:0046385 deoxyribose phosphate biosynthetic process 2/982 12/18722 0.12811174316898 0.413861301273793 DTYMK/ADK 2 GO:0046831 regulation of RNA export from nucleus 2/982 12/18722 0.12811174316898 0.413861301273793 DHX9/NUP153 2 GO:0048548 regulation of pinocytosis 2/982 12/18722 0.12811174316898 0.413861301273793 PROM2/CLN3 2 GO:0051255 spindle midzone assembly 2/982 12/18722 0.12811174316898 0.413861301273793 RACGAP1/KIF4A 2 GO:0051340 regulation of ligase activity 2/982 12/18722 0.12811174316898 0.413861301273793 TMSB4X/GCLM 2 GO:0051639 actin filament network formation 2/982 12/18722 0.12811174316898 0.413861301273793 COBL/ACTN1 2 GO:0060019 radial glial cell differentiation 2/982 12/18722 0.12811174316898 0.413861301273793 GLI3/METTL3 2 GO:0060221 retinal rod cell differentiation 2/982 12/18722 0.12811174316898 0.413861301273793 NAGLU/PTN 2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/982 12/18722 0.12811174316898 0.413861301273793 LRP1/PPARG 2 GO:0060442 branching involved in prostate gland morphogenesis 2/982 12/18722 0.12811174316898 0.413861301273793 FGFR2/BMP7 2 GO:0060601 lateral sprouting from an epithelium 2/982 12/18722 0.12811174316898 0.413861301273793 FGFR2/BMP7 2 GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/982 12/18722 0.12811174316898 0.413861301273793 BMP7/FOLR1 2 GO:0061308 cardiac neural crest cell development involved in heart development 2/982 12/18722 0.12811174316898 0.413861301273793 BMP7/FOLR1 2 GO:0061430 bone trabecula morphogenesis 2/982 12/18722 0.12811174316898 0.413861301273793 FBN2/PLXNB1 2 GO:0070170 regulation of tooth mineralization 2/982 12/18722 0.12811174316898 0.413861301273793 SLC4A2/TFAP2A 2 GO:0071941 nitrogen cycle metabolic process 2/982 12/18722 0.12811174316898 0.413861301273793 CEBPA/ASS1 2 GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/982 12/18722 0.12811174316898 0.413861301273793 YAP1/CD24 2 GO:0090177 establishment of planar polarity involved in neural tube closure 2/982 12/18722 0.12811174316898 0.413861301273793 DVL3/NPHP3 2 GO:0090331 negative regulation of platelet aggregation 2/982 12/18722 0.12811174316898 0.413861301273793 UBASH3B/C1QTNF1 2 GO:0090385 phagosome-lysosome fusion 2/982 12/18722 0.12811174316898 0.413861301273793 SYT7/CLN3 2 GO:0120263 positive regulation of heterochromatin organization 2/982 12/18722 0.12811174316898 0.413861301273793 TRIM28/DNMT1 2 GO:1903909 regulation of receptor clustering 2/982 12/18722 0.12811174316898 0.413861301273793 PTN/GSN 2 GO:1904748 regulation of apoptotic process involved in development 2/982 12/18722 0.12811174316898 0.413861301273793 BMP7/FOXC1 2 GO:1905245 regulation of aspartic-type peptidase activity 2/982 12/18722 0.12811174316898 0.413861301273793 EFNA1/GRN 2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 3/982 24/18722 0.128776244625645 0.413861301273793 HLA-B/HLA-A/HLA-E 3 GO:0002726 positive regulation of T cell cytokine production 3/982 24/18722 0.128776244625645 0.413861301273793 B2M/HLA-A/MAP3K7 3 GO:0003181 atrioventricular valve morphogenesis 3/982 24/18722 0.128776244625645 0.413861301273793 SOX4/EFNA1/MDM2 3 GO:0021801 cerebral cortex radial glia-guided migration 3/982 24/18722 0.128776244625645 0.413861301273793 LAMB1/ADGRG1/GLI3 3 GO:0022030 telencephalon glial cell migration 3/982 24/18722 0.128776244625645 0.413861301273793 LAMB1/ADGRG1/GLI3 3 GO:0030859 polarized epithelial cell differentiation 3/982 24/18722 0.128776244625645 0.413861301273793 DLG5/FAT1/AHI1 3 GO:0032928 regulation of superoxide anion generation 3/982 24/18722 0.128776244625645 0.413861301273793 EGFR/CYBA/GSTP1 3 GO:0038095 Fc-epsilon receptor signaling pathway 3/982 24/18722 0.128776244625645 0.413861301273793 FER/MAP3K7/VAV3 3 GO:0044321 response to leptin 3/982 24/18722 0.128776244625645 0.413861301273793 LRP2/CCND1/CCNA2 3 GO:0051905 establishment of pigment granule localization 3/982 24/18722 0.128776244625645 0.413861301273793 MYO7A/MREG/RAB17 3 GO:0060149 negative regulation of posttranscriptional gene silencing 3/982 24/18722 0.128776244625645 0.413861301273793 KCNQ1OT1/LIN28B/PPARG 3 GO:0060479 lung cell differentiation 3/982 24/18722 0.128776244625645 0.413861301273793 YAP1/NFIB/RBPJ 3 GO:0060561 apoptotic process involved in morphogenesis 3/982 24/18722 0.128776244625645 0.413861301273793 LRP5/BMP7/FOXC1 3 GO:0060571 morphogenesis of an epithelial fold 3/982 24/18722 0.128776244625645 0.413861301273793 FGFR2/BMP7/RDH10 3 GO:0060967 negative regulation of gene silencing by RNA 3/982 24/18722 0.128776244625645 0.413861301273793 KCNQ1OT1/LIN28B/PPARG 3 GO:0072010 glomerular epithelium development 3/982 24/18722 0.128776244625645 0.413861301273793 CD24/BASP1/FOXC1 3 GO:0090343 positive regulation of cell aging 3/982 24/18722 0.128776244625645 0.413861301273793 PAWR/B2M/LMNA 3 GO:2001026 regulation of endothelial cell chemotaxis 3/982 24/18722 0.128776244625645 0.413861301273793 MET/TMSB4X/LGMN 3 GO:0032984 protein-containing complex disassembly 16/982 224/18722 0.130693455490971 0.419577964432003 SCIN/SWAP70/MICAL3/IGF1R/TRIOBP/SYNJ1/CLN3/HDAC6/CAMSAP2/EPS8/ABCE1/LIMA1/TPX2/GSN/NAPA/PHF23 16 GO:0015914 phospholipid transport 8/982 96/18722 0.130876792203004 0.419577964432003 OSBPL10/PLEKHA8/TMEM30B/LDLR/KCNN4/TRIAP1/ATP10D/SCARB2 8 GO:0055017 cardiac muscle tissue growth 8/982 96/18722 0.130876792203004 0.419577964432003 GJA1/FGFR2/PARP2/YAP1/TGFBR3/FOXC1/VGLL4/RBPJ 8 GO:1904035 regulation of epithelial cell apoptotic process 8/982 96/18722 0.130876792203004 0.419577964432003 YAP1/WFS1/PRKCI/NUPR1/GSN/TCF7L2/BAD/PDPK1 8 GO:0038061 NIK/NF-kappaB signaling 11/982 143/18722 0.131148406206058 0.420097538216506 EGFR/APP/BMP7/TMSB4X/TRAF4/NFAT5/MAP3K7/TRIP6/TSPAN6/PRDX1/EDARADD 11 GO:0035966 response to topologically incorrect protein 12/982 159/18722 0.131199940520454 0.420097538216506 SERPINH1/UGGT2/WFS1/DNAJB4/HSPA4L/CCND1/HDAC6/TMEM33/TM7SF3/CREB3L2/CREB3/FAF2 12 GO:0071300 cellular response to retinoic acid 6/982 66/18722 0.131552391495536 0.420967652785714 SLC6A4/FZD10/FGFR2/YAP1/SERPINF1/YES1 6 GO:0000422 autophagy of mitochondrion 7/982 81/18722 0.132118534244724 0.421486406495705 WIPI2/CTTN/SLC25A4/HDAC6/PINK1/GABARAPL1/HUWE1 7 GO:0001523 retinoid metabolic process 7/982 81/18722 0.132118534244724 0.421486406495705 LRP2/LRP1/RDH10/RDH14/PPARD/PNPLA2/AKR1B1 7 GO:0051817 modulation of process of other organism involved in symbiotic interaction 7/982 81/18722 0.132118534244724 0.421486406495705 DAG1/EIF2AK4/TARDBP/CCL5/RXRA/RRAGA/TAF11 7 GO:0061726 mitochondrion disassembly 7/982 81/18722 0.132118534244724 0.421486406495705 WIPI2/CTTN/SLC25A4/HDAC6/PINK1/GABARAPL1/HUWE1 7 GO:2001021 negative regulation of response to DNA damage stimulus 7/982 81/18722 0.132118534244724 0.421486406495705 POLQ/MDM2/TRIAP1/RMI2/MAGEF1/USP47/PTTG1IP 7 GO:0018205 peptidyl-lysine modification 25/982 376/18722 0.133314754284926 0.425042639578345 PLOD2/ISL1/SOX4/BRD4/P3H4/VIPAS39/TGM2/MAP3K7/TET2/NCOA3/CBX4/HDAC6/MORF4L2/MDM2/LMNA/ZNF451/BRCA2/RANBP2/TRIM28/RPS6KA4/MED24/GCSH/DNMT1/KMT5A/TRIM27 25 GO:0031348 negative regulation of defense response 18/982 258/18722 0.133637214932656 0.425810453933254 CD200/ISL1/PPARG/HLA-B/HLA-A/LDLR/SERPINF1/YES1/MVK/HLA-E/PPARD/YTHDF2/TSPAN6/GSTP1/GRN/PLK2/METTL3/FEM1A 18 GO:1901222 regulation of NIK/NF-kappaB signaling 9/982 112/18722 0.133725208131784 0.425830699398891 EGFR/APP/BMP7/TMSB4X/NFAT5/TRIP6/TSPAN6/PRDX1/EDARADD 9 GO:0035637 multicellular organismal signaling 12/982 160/18722 0.135507553914358 0.430007721553857 GJA1/GJA5/DSG2/DSP/ISL1/DSC2/CLDN19/JAM3/ATP2B1/PKP2/ANK3/EHD3 12 GO:0035196 production of miRNAs involved in gene silencing by miRNA 5/982 52/18722 0.13567182089235 0.430007721553857 EGFR/LIN28B/PUM1/PUM2/METTL3 5 GO:0043090 amino acid import 5/982 52/18722 0.13567182089235 0.430007721553857 SLC1A3/SLC43A2/SLC1A5/ITGB1/SLC7A2 5 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 5/982 52/18722 0.13567182089235 0.430007721553857 DVL3/ZNRF3/DAB2/FZD6/NPHP3 5 GO:0106106 cold-induced thermogenesis 11/982 144/18722 0.135706054160063 0.430007721553857 GJA1/LGR4/ESRRG/PRLR/ADRB1/EPAS1/ACVR2B/ID1/IGF1R/FH/RBPJ 11 GO:0120161 regulation of cold-induced thermogenesis 11/982 144/18722 0.135706054160063 0.430007721553857 GJA1/LGR4/ESRRG/PRLR/ADRB1/EPAS1/ACVR2B/ID1/IGF1R/FH/RBPJ 11 GO:0007094 mitotic spindle assembly checkpoint signaling 4/982 38/18722 0.136465385876773 0.430007721553857 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0032373 positive regulation of sterol transport 4/982 38/18722 0.136465385876773 0.430007721553857 LRP1/PPARG/RXRA/ANXA2 4 GO:0032376 positive regulation of cholesterol transport 4/982 38/18722 0.136465385876773 0.430007721553857 LRP1/PPARG/RXRA/ANXA2 4 GO:0042596 fear response 4/982 38/18722 0.136465385876773 0.430007721553857 GJA1/ADRB1/ALS2/DPP4 4 GO:0048713 regulation of oligodendrocyte differentiation 4/982 38/18722 0.136465385876773 0.430007721553857 DAG1/PTN/NF1/TNFRSF21 4 GO:0071173 spindle assembly checkpoint signaling 4/982 38/18722 0.136465385876773 0.430007721553857 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0071174 mitotic spindle checkpoint signaling 4/982 38/18722 0.136465385876773 0.430007721553857 CENPF/ZWINT/SPDL1/LCMT1 4 GO:1903580 positive regulation of ATP metabolic process 4/982 38/18722 0.136465385876773 0.430007721553857 APP/TMSB4X/PINK1/NUPR1 4 GO:1903725 regulation of phospholipid metabolic process 4/982 38/18722 0.136465385876773 0.430007721553857 LDLR/RAB38/PDGFA/IDH1 4 GO:0006721 terpenoid metabolic process 8/982 97/18722 0.136520856382896 0.430007721553857 LRP2/EGFR/LRP1/RDH10/RDH14/PPARD/PNPLA2/AKR1B1 8 GO:0043255 regulation of carbohydrate biosynthetic process 8/982 97/18722 0.136520856382896 0.430007721553857 SLC35B4/SORBS1/DDB1/PPP1R3E/P2RY6/CLTC/RANBP2/IRS2 8 GO:0070167 regulation of biomineral tissue development 8/982 97/18722 0.136520856382896 0.430007721553857 FBN2/BMP7/SLC4A2/PTN/NOTUM/ACVR2B/ATP2B1/TFAP2A 8 GO:0045927 positive regulation of growth 18/982 259/18722 0.137013458099448 0.431298851808523 EGFR/LRP1/FGFR2/PARP2/YAP1/NRP1/MMP14/TGFBR3/GPAM/CHD7/CYFIP1/WFS1/BASP1/PPARD/CYBA/MAP3K13/USP47/RBPJ 18 GO:0016575 histone deacetylation 7/982 82/18722 0.138348668745746 0.434688971209948 MTA3/RCOR1/TBL1X/HDAC6/MORF4L2/PINK1/SIN3B 7 GO:0060395 SMAD protein signal transduction 7/982 82/18722 0.138348668745746 0.434688971209948 LRP1/BMP7/PPARG/RBPMS/DAB2/SMAD5/VIM 7 GO:0072527 pyrimidine-containing compound metabolic process 7/982 82/18722 0.138348668745746 0.434688971209948 SLC19A3/TK1/TET2/NME4/DTYMK/NME1/RRM1 7 GO:0061180 mammary gland epithelium development 6/982 67/18722 0.138507107007464 0.434688971209948 LRP5/FGFR2/KDM5B/CCND1/TBX3/BRCA2 6 GO:1903317 regulation of protein maturation 6/982 67/18722 0.138507107007464 0.434688971209948 SOX4/MMP14/CLN3/MDM2/GSN/GLG1 6 GO:0051648 vesicle localization 13/982 177/18722 0.138944720525329 0.435800157703017 MYO7A/MREG/LIMK2/SYNJ1/WASL/FNBP1L/CLN3/PINK1/TFG/RAB17/AP1M2/TRIP11/TMED9 13 GO:0034101 erythrocyte homeostasis 10/982 129/18722 0.140133813240212 0.436574058893052 TGFBR3/EPAS1/B2M/RCOR1/SLC11A2/CDK6/UBA5/PRDX1/SMAD5/ALAS1 10 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 3/982 25/18722 0.140949140179429 0.436574058893052 GJA1/GJA5/CYBA 3 GO:0003094 glomerular filtration 3/982 25/18722 0.140949140179429 0.436574058893052 GJA1/GJA5/CYBA 3 GO:0006658 phosphatidylserine metabolic process 3/982 25/18722 0.140949140179429 0.436574058893052 OSBPL10/ABHD12/SERINC2 3 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 3/982 25/18722 0.140949140179429 0.436574058893052 NME4/DTYMK/NME1 3 GO:0010842 retina layer formation 3/982 25/18722 0.140949140179429 0.436574058893052 OBSL1/TFAP2A/AHI1 3 GO:0016540 protein autoprocessing 3/982 25/18722 0.140949140179429 0.436574058893052 PISD/CTSL/AFG3L2 3 GO:0030318 melanocyte differentiation 3/982 25/18722 0.140949140179429 0.436574058893052 MREG/GNA11/GLI3 3 GO:0032469 endoplasmic reticulum calcium ion homeostasis 3/982 25/18722 0.140949140179429 0.436574058893052 APP/WFS1/TGM2 3 GO:0033622 integrin activation 3/982 25/18722 0.140949140179429 0.436574058893052 FERMT1/JAM3/FERMT2 3 GO:0036315 cellular response to sterol 3/982 25/18722 0.140949140179429 0.436574058893052 DAG1/LRP6/INSIG1 3 GO:0045109 intermediate filament organization 3/982 25/18722 0.140949140179429 0.436574058893052 DSP/PKP2/VIM 3 GO:0046039 GTP metabolic process 3/982 25/18722 0.140949140179429 0.436574058893052 NME4/IMPDH2/NME1 3 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 3/982 25/18722 0.140949140179429 0.436574058893052 MED16/CAND1/MED24 3 GO:0060706 cell differentiation involved in embryonic placenta development 3/982 25/18722 0.140949140179429 0.436574058893052 NR2F2/SPINT2/KRT8 3 GO:0061436 establishment of skin barrier 3/982 25/18722 0.140949140179429 0.436574058893052 MET/LSR/CLDN4 3 GO:0062009 secondary palate development 3/982 25/18722 0.140949140179429 0.436574058893052 TGFBR3/ITGB8/CHD7 3 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 3/982 25/18722 0.140949140179429 0.436574058893052 GJA1/GJA5/PKP2 3 GO:1903959 regulation of anion transmembrane transport 3/982 25/18722 0.140949140179429 0.436574058893052 TCAF1/SLC43A2/ITGB1 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/982 25/18722 0.140949140179429 0.436574058893052 ADAMTS1/LRP1/MDM2 3 GO:1905048 regulation of metallopeptidase activity 3/982 25/18722 0.140949140179429 0.436574058893052 LRP1/CLDN4/TIMP3 3 GO:0050777 negative regulation of immune response 14/982 194/18722 0.141644341682615 0.437250147167261 PPARG/FER/CD46/HLA-B/HLA-A/YES1/HLA-E/YTHDF2/CD59/TSPAN6/GRN/PLK2/METTL3/TRIM27 14 GO:0010948 negative regulation of cell cycle process 20/982 294/18722 0.141759578412748 0.437250147167261 BMP7/SOX4/WEE1/EIF2AK4/CENPF/CTDSPL/BRCC3/FOXO4/CCND1/ZWINT/SPDL1/MDM2/TRIAP1/TRIM37/ATR/PLK2/TOPBP1/GTSE1/USP47/LCMT1 20 GO:1902882 regulation of response to oxidative stress 8/982 98/18722 0.142285788554953 0.437250147167261 MET/BMP7/PAWR/FUT8/PAGE4/HDAC6/P4HB/PINK1 8 GO:0001558 regulation of cell growth 27/982 414/18722 0.143602480131803 0.437250147167261 GJA1/SEMA6D/SEMA6A/NET1/EGFR/LRP1/SH3BP4/PARP2/NRP1/DCBLD2/MMP14/SEMA3F/SERTAD3/SEMA4C/CYFIP1/CTTN/ARHGEF11/SMARCA2/CHPT1/DPYSL2/PPARD/CYBA/MAP3K13/SERTAD2/EPB41L3/USP47/VGLL4 27 GO:0008347 glial cell migration 5/982 53/18722 0.143764965773433 0.437250147167261 LAMB1/LRP1/MMP14/ADGRG1/GLI3 5 GO:0033059 cellular pigmentation 5/982 53/18722 0.143764965773433 0.437250147167261 ANKRD27/MYO7A/MREG/RAB38/RAB17 5 GO:0050819 negative regulation of coagulation 5/982 53/18722 0.143764965773433 0.437250147167261 UBASH3B/ANXA5/C1QTNF1/PDGFA/ANXA2 5 GO:1990090 cellular response to nerve growth factor stimulus 5/982 53/18722 0.143764965773433 0.437250147167261 APP/ID1/MICALL1/PDPK1/DYNC1LI2 5 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9/982 114/18722 0.144356709392737 0.437250147167261 BMP7/FERMT1/TGFBR3/PPARG/ACVR2B/RBPMS/DAB2/CDKN1C/RBPJ 9 GO:0050886 endocrine process 7/982 83/18722 0.144719049879108 0.437250147167261 GJA1/ENPEP/MME/TRPV6/C1QTNF1/TBX3/CYBA 7 GO:0006282 regulation of DNA repair 10/982 130/18722 0.145159004394608 0.437250147167261 EGFR/POLQ/BRCC3/AXIN2/WRNIP1/RMI2/MAGEF1/DHX9/WDR48/TRIM28 10 GO:0015918 sterol transport 10/982 130/18722 0.145159004394608 0.437250147167261 LRP1/OSBPL10/SYT7/PPARG/LRP6/TSKU/LDLR/RXRA/LIMA1/ANXA2 10 GO:0007059 chromosome segregation 23/982 346/18722 0.145206692430343 0.437250147167261 CENPF/SMC2/P3H4/CHTF8/AXIN2/ZWINT/PUM1/SPDL1/RACGAP1/FEN1/RMI2/BEX4/PUM2/TOP2A/CENPW/NEK8/BIRC5/TOP1/KMT5A/CCNE1/KIF4A/SRPK1/LCMT1 23 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 6/982 68/18722 0.145629483470464 0.437250147167261 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/NME1 6 GO:0009247 glycolipid biosynthetic process 6/982 68/18722 0.145629483470464 0.437250147167261 PGAP2/PGAP1/B3GNT5/PIGU/PIGF/GPAA1 6 GO:0046686 response to cadmium ion 6/982 68/18722 0.145629483470464 0.437250147167261 EGFR/B2M/ALAD/GSS/SPARC/DTYMK 6 GO:0061912 selective autophagy 6/982 68/18722 0.145629483470464 0.437250147167261 WIPI2/SLC25A4/HDAC6/PINK1/UBA5/HUWE1 6 GO:1901607 alpha-amino acid biosynthetic process 6/982 68/18722 0.145629483470464 0.437250147167261 PLOD2/PSAT1/CLN3/ASNSD1/AASDHPPT/ASS1 6 GO:0001914 regulation of T cell mediated cytotoxicity 4/982 39/18722 0.146152402915836 0.437250147167261 B2M/HLA-B/HLA-A/HLA-E 4 GO:0031577 spindle checkpoint signaling 4/982 39/18722 0.146152402915836 0.437250147167261 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0034314 Arp2/3 complex-mediated actin nucleation 4/982 39/18722 0.146152402915836 0.437250147167261 CYFIP1/NCKAP1/WASL/TRIM27 4 GO:0046326 positive regulation of glucose import 4/982 39/18722 0.146152402915836 0.437250147167261 SORBS1/PRKCI/IRS2/OPN3 4 GO:2000785 regulation of autophagosome assembly 4/982 39/18722 0.146152402915836 0.437250147167261 PINK1/TBC1D12/NUPR1/PHF23 4 GO:0001768 establishment of T cell polarity 2/982 13/18722 0.14636479236082 0.437250147167261 GSN/FLOT2 2 GO:0001778 plasma membrane repair 2/982 13/18722 0.14636479236082 0.437250147167261 SYT7/MYOF 2 GO:0001886 endothelial cell morphogenesis 2/982 13/18722 0.14636479236082 0.437250147167261 MET/CLIC4 2 GO:0002551 mast cell chemotaxis 2/982 13/18722 0.14636479236082 0.437250147167261 SWAP70/PGF 2 GO:0003222 ventricular trabecula myocardium morphogenesis 2/982 13/18722 0.14636479236082 0.437250147167261 CHD7/RBPJ 2 GO:0007494 midgut development 2/982 13/18722 0.14636479236082 0.437250147167261 EGFR/ASS1 2 GO:0009650 UV protection 2/982 13/18722 0.14636479236082 0.437250147167261 SCARA3/FEN1 2 GO:0010635 regulation of mitochondrial fusion 2/982 13/18722 0.14636479236082 0.437250147167261 TFRC/HUWE1 2 GO:0010745 negative regulation of macrophage derived foam cell differentiation 2/982 13/18722 0.14636479236082 0.437250147167261 ITGAV/PPARG 2 GO:0010958 regulation of amino acid import across plasma membrane 2/982 13/18722 0.14636479236082 0.437250147167261 SLC43A2/ITGB1 2 GO:0010960 magnesium ion homeostasis 2/982 13/18722 0.14636479236082 0.437250147167261 EGFR/ANK3 2 GO:0021514 ventral spinal cord interneuron differentiation 2/982 13/18722 0.14636479236082 0.437250147167261 GLI3/LMO4 2 GO:0021554 optic nerve development 2/982 13/18722 0.14636479236082 0.437250147167261 GLI3/NAV2 2 GO:0021819 layer formation in cerebral cortex 2/982 13/18722 0.14636479236082 0.437250147167261 ADGRG1/GLI3 2 GO:0031053 primary miRNA processing 2/982 13/18722 0.14636479236082 0.437250147167261 LIN28B/METTL3 2 GO:0032352 positive regulation of hormone metabolic process 2/982 13/18722 0.14636479236082 0.437250147167261 RDH10/ADM 2 GO:0032429 regulation of phospholipase A2 activity 2/982 13/18722 0.14636479236082 0.437250147167261 EGFR/LRP1 2 GO:0032905 transforming growth factor beta1 production 2/982 13/18722 0.14636479236082 0.437250147167261 TSKU/CD2AP 2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 2/982 13/18722 0.14636479236082 0.437250147167261 BRD4/ELL 2 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 2/982 13/18722 0.14636479236082 0.437250147167261 SKP2/YAP1 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/982 13/18722 0.14636479236082 0.437250147167261 TIMP3/ZDHHC3 2 GO:0042659 regulation of cell fate specification 2/982 13/18722 0.14636479236082 0.437250147167261 ESRP1/LMO4 2 GO:0044090 positive regulation of vacuole organization 2/982 13/18722 0.14636479236082 0.437250147167261 GRN/ANXA2 2 GO:0046415 urate metabolic process 2/982 13/18722 0.14636479236082 0.437250147167261 ABCG2/SLC22A11 2 GO:0046689 response to mercury ion 2/982 13/18722 0.14636479236082 0.437250147167261 ALAD/BSG 2 GO:0048012 hepatocyte growth factor receptor signaling pathway 2/982 13/18722 0.14636479236082 0.437250147167261 MET/NRP1 2 GO:0048820 hair follicle maturation 2/982 13/18722 0.14636479236082 0.437250147167261 FERMT1/RBPJ 2 GO:0051451 myoblast migration 2/982 13/18722 0.14636479236082 0.437250147167261 NET1/BIN3 2 GO:0051481 negative regulation of cytosolic calcium ion concentration 2/982 13/18722 0.14636479236082 0.437250147167261 LRP1/ATP2B1 2 GO:0061000 negative regulation of dendritic spine development 2/982 13/18722 0.14636479236082 0.437250147167261 EFNA1/PLK2 2 GO:0070254 mucus secretion 2/982 13/18722 0.14636479236082 0.437250147167261 EGFR/CYBA 2 GO:0071696 ectodermal placode development 2/982 13/18722 0.14636479236082 0.437250147167261 NRP1/TBX3 2 GO:0090042 tubulin deacetylation 2/982 13/18722 0.14636479236082 0.437250147167261 HDAC6/BEX4 2 GO:1900121 negative regulation of receptor binding 2/982 13/18722 0.14636479236082 0.437250147167261 B2M/PTPRF 2 GO:1901096 regulation of autophagosome maturation 2/982 13/18722 0.14636479236082 0.437250147167261 CLN3/PHF23 2 GO:1903054 negative regulation of extracellular matrix organization 2/982 13/18722 0.14636479236082 0.437250147167261 CST3/DPP4 2 GO:1903789 regulation of amino acid transmembrane transport 2/982 13/18722 0.14636479236082 0.437250147167261 SLC43A2/ITGB1 2 GO:1905244 regulation of modification of synaptic structure 2/982 13/18722 0.14636479236082 0.437250147167261 CYFIP1/CLN3 2 GO:1905269 positive regulation of chromatin organization 2/982 13/18722 0.14636479236082 0.437250147167261 TRIM28/DNMT1 2 GO:0006469 negative regulation of protein kinase activity 15/982 212/18722 0.147679088602931 0.440923941701711 NR2F2/LRP5/BMP7/UBASH3B/PPARG/NF1/LRP6/LATS2/CDKN1C/CEBPA/MLLT1/PKIB/GSTP1/TRIM27/PDPK1 15 GO:0110149 regulation of biomineralization 8/982 99/18722 0.148169490063822 0.442135045865501 FBN2/BMP7/SLC4A2/PTN/NOTUM/ACVR2B/ATP2B1/TFAP2A 8 GO:0072521 purine-containing compound metabolic process 27/982 416/18722 0.149173845269718 0.444877516824957 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC 27 GO:0046916 cellular transition metal ion homeostasis 9/982 115/18722 0.149828145490425 0.446134465107865 APP/TFRC/ACO1/ANKRD9/SLC39A10/SLC40A1/SLC11A2/SLC39A7/SCO1 9 GO:0022408 negative regulation of cell-cell adhesion 14/982 196/18722 0.149851913893593 0.446134465107865 CDH1/SOCS6/PAWR/UBASH3B/SWAP70/DLG5/SPINT2/TNFRSF21/GLI3/PTK2/C1QTNF1/YTHDF2/METTL3/ASS1 14 GO:0043393 regulation of protein binding 14/982 196/18722 0.149851913893593 0.446134465107865 LRP1/APP/UBASH3B/NRP1/TGFBR3/B2M/ID1/DAB2/PTPRF/PHLDA2/PPP2CB/PLK2/TCF7L2/ANXA2 14 GO:0002683 negative regulation of immune system process 28/982 434/18722 0.151186933055798 0.448945975655755 FBN1/CD200/SOCS6/PAWR/UBASH3B/PPARG/GPAM/FER/DLG5/TNFRSF21/CD46/HLA-B/HLA-A/LDLR/GLI3/WASL/YES1/HLA-E/YTHDF2/CDK6/CD59/TSPAN6/GRN/PLK2/METTL3/DPP4/TRIM27/NME1 28 GO:0032370 positive regulation of lipid transport 7/982 84/18722 0.151226625618704 0.448945975655755 LRP1/PPARG/PTGES/C1QTNF1/TRIAP1/RXRA/ANXA2 7 GO:0042440 pigment metabolic process 7/982 84/18722 0.151226625618704 0.448945975655755 ALAD/NFE2L1/SLC11A2/PPOX/PPAT/ALAS1/OPN3 7 GO:0097061 dendritic spine organization 7/982 84/18722 0.151226625618704 0.448945975655755 PPP1R9A/CTTN/IGF1R/EFNA1/WASL/HDAC6/LGMN 7 GO:0098586 cellular response to virus 7/982 84/18722 0.151226625618704 0.448945975655755 TRIM6/IFI6/PUM1/ZCCHC3/CCL5/TSPAN6/PUM2 7 GO:0015698 inorganic anion transport 13/982 180/18722 0.151817084735835 0.449885664688495 SLC26A2/GABRE/CLDN4/GPR89A/SLC4A2/SLC1A3/FXYD3/SLC22A11/MFSD5/P2RY6/RACGAP1/CLIC4/LRRC8D 13 GO:0031050 dsRNA processing 5/982 54/18722 0.152060664656023 0.449885664688495 EGFR/LIN28B/PUM1/PUM2/METTL3 5 GO:0032330 regulation of chondrocyte differentiation 5/982 54/18722 0.152060664656023 0.449885664688495 SCIN/EFEMP1/GLI3/AXIN2/GLG1 5 GO:0070918 production of small RNA involved in gene silencing by RNA 5/982 54/18722 0.152060664656023 0.449885664688495 EGFR/LIN28B/PUM1/PUM2/METTL3 5 GO:1902743 regulation of lamellipodium organization 5/982 54/18722 0.152060664656023 0.449885664688495 KANK1/FER/CYFIP1/NCKAP1/BIN3 5 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 5/982 54/18722 0.152060664656023 0.449885664688495 TEAD1/NFIB/PPARG/PPARD/KLF5 5 GO:0016197 endosomal transport 16/982 230/18722 0.15301821381909 0.450800873776531 ANKRD27/ALS2/TINAGL1/NSG1/RHOBTB3/SNX4/EVI5/RAB13/MICALL1/TMEM87A/CLTC/DENND5A/RAB17/LEPROT/EHD3/TRIM27 16 GO:0002026 regulation of the force of heart contraction 3/982 26/18722 0.153487734107653 0.450800873776531 ADRB1/GAA/ADM 3 GO:0006760 folic acid-containing compound metabolic process 3/982 26/18722 0.153487734107653 0.450800873776531 SLC19A1/FOLR1/ATIC 3 GO:0010875 positive regulation of cholesterol efflux 3/982 26/18722 0.153487734107653 0.450800873776531 LRP1/PPARG/RXRA 3 GO:0033598 mammary gland epithelial cell proliferation 3/982 26/18722 0.153487734107653 0.450800873776531 KDM5B/CCND1/BRCA2 3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 3/982 26/18722 0.153487734107653 0.450800873776531 SLC39A10/KCNN4/BCL10 3 GO:0051875 pigment granule localization 3/982 26/18722 0.153487734107653 0.450800873776531 MYO7A/MREG/RAB17 3 GO:0060037 pharyngeal system development 3/982 26/18722 0.153487734107653 0.450800873776531 BMP7/ISL1/FOLR1 3 GO:0097186 amelogenesis 3/982 26/18722 0.153487734107653 0.450800873776531 CSF3R/SLC4A2/PERP 3 GO:0097205 renal filtration 3/982 26/18722 0.153487734107653 0.450800873776531 GJA1/GJA5/CYBA 3 GO:1905523 positive regulation of macrophage migration 3/982 26/18722 0.153487734107653 0.450800873776531 MMP14/PTK2/CCL5 3 GO:2000050 regulation of non-canonical Wnt signaling pathway 3/982 26/18722 0.153487734107653 0.450800873776531 ZNRF3/DAB2/NPHP3 3 GO:0050792 regulation of viral process 12/982 164/18722 0.15349354904661 0.450800873776531 TRIML2/DDB1/TRIM6/HACD3/P4HB/CCL5/TOP2A/DHX9/TRIM28/GSN/TRIM27/SRPK1 12 GO:0110020 regulation of actomyosin structure organization 8/982 100/18722 0.154169727816269 0.452531964147249 MET/TACSTD2/NRP1/PPP1R9A/TJP1/FERMT2/PPFIA1/F11R 8 GO:1903900 regulation of viral life cycle 11/982 148/18722 0.154768736430137 0.454034718346228 TRIML2/DDB1/TRIM6/HACD3/P4HB/CCL5/TOP2A/TRIM28/GSN/TRIM27/SRPK1 11 GO:0007569 cell aging 10/982 132/18722 0.155482622321342 0.455287930518085 PAWR/MME/B2M/HRAS/TBX3/CDK6/LMNA/ATR/PLK2/BRCA2 10 GO:0010863 positive regulation of phospholipase C activity 4/982 40/18722 0.156097327342659 0.455287930518085 EGFR/FLT1/HRAS/P2RY6 4 GO:0045740 positive regulation of DNA replication 4/982 40/18722 0.156097327342659 0.455287930518085 EGFR/HRAS/BCAR3/DHX9 4 GO:0045777 positive regulation of blood pressure 4/982 40/18722 0.156097327342659 0.455287930518085 NR2F2/ADRB1/CYBA/F11R 4 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 4/982 40/18722 0.156097327342659 0.455287930518085 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0046365 monosaccharide catabolic process 4/982 40/18722 0.156097327342659 0.455287930518085 LRP5/FUT8/RPE/BAD 4 GO:0150077 regulation of neuroinflammatory response 4/982 40/18722 0.156097327342659 0.455287930518085 CD200/LDLR/NUPR1/GRN 4 GO:1901661 quinone metabolic process 4/982 40/18722 0.156097327342659 0.455287930518085 PDSS2/COQ5/COQ6/AKR1B1 4 GO:1901998 toxin transport 4/982 40/18722 0.156097327342659 0.455287930518085 NRP1/LRP6/ANTXR2/COPB2 4 GO:2000142 regulation of DNA-templated transcription, initiation 4/982 40/18722 0.156097327342659 0.455287930518085 ZNF451/MED16/CAND1/MED24 4 GO:0008361 regulation of cell size 13/982 181/18722 0.156243365726107 0.455287930518085 SEMA6D/SEMA6A/LRP1/NRP1/SEMA3F/SEMA4C/CYFIP1/CTTN/KCNN4/CLN3/DPYSL2/MAP3K13/VAV3 13 GO:1905952 regulation of lipid localization 13/982 181/18722 0.156243365726107 0.455287930518085 ITGAV/LRP1/KDM5B/PPARG/PTGES/HILPDA/PPARD/C1QTNF1/TRIAP1/PNPLA2/RXRA/IRS2/ANXA2 13 GO:0045069 regulation of viral genome replication 7/982 85/18722 0.157868169957561 0.459765703237653 DDB1/TRIM6/HACD3/CCL5/TOP2A/TRIM28/SRPK1 7 GO:0016053 organic acid biosynthetic process 21/982 316/18722 0.158420651676427 0.461117253986741 SLC27A2/PLOD2/ACSS1/PSAT1/SLC1A3/RDH10/MGST3/DEGS1/PTGES/HACD3/CLN3/ACADVL/ASNSD1/AASDHPPT/GSTP1/DECR2/INSIG1/SUCLA2/HSD17B12/CDO1/ASS1 21 GO:0006476 protein deacetylation 8/982 101/18722 0.160284139597409 0.465758997177827 MTA3/RCOR1/TBL1X/HDAC6/MORF4L2/BEX4/PINK1/SIN3B 8 GO:0042102 positive regulation of T cell proliferation 8/982 101/18722 0.160284139597409 0.465758997177827 TFRC/IL6ST/GPAM/CD46/HLA-A/CD24/HLA-E/CCL5 8 GO:0003407 neural retina development 6/982 70/18722 0.160358507958848 0.465758997177827 OBSL1/NAGLU/PTN/ATP2B1/TFAP2A/AHI1 6 GO:0010676 positive regulation of cellular carbohydrate metabolic process 5/982 55/18722 0.160551126711222 0.465758997177827 SORBS1/DDB1/PPP1R3E/P2RY6/IRS2 5 GO:0061614 pri-miRNA transcription by RNA polymerase II 5/982 55/18722 0.160551126711222 0.465758997177827 TEAD1/NFIB/PPARG/PPARD/KLF5 5 GO:0098900 regulation of action potential 5/982 55/18722 0.160551126711222 0.465758997177827 GJA5/DSG2/DSP/DSC2/PKP2 5 GO:0046328 regulation of JNK cascade 10/982 133/18722 0.160778358815655 0.466158932508314 EGFR/APP/TRAF4/MARVELD3/IGF1R/HRAS/PHLPP1/PINK1/MAP4K4/GSTP1 10 GO:0030301 cholesterol transport 9/982 117/18722 0.161073953854118 0.466756524057266 LRP1/SYT7/PPARG/LRP6/TSKU/LDLR/RXRA/LIMA1/ANXA2 9 GO:2000117 negative regulation of cysteine-type endopeptidase activity 7/982 86/18722 0.164640292154657 0.468538532567461 DHCR24/IFI6/MDM2/TRIAP1/USP47/BIRC5/PRDX5 7 GO:2001251 negative regulation of chromosome organization 7/982 86/18722 0.164640292154657 0.468538532567461 CENPF/MCM2/ZWINT/SPDL1/TOP2A/LCMT1/RAD50 7 GO:0000054 ribosomal subunit export from nucleus 2/982 14/18722 0.165103135843403 0.468538532567461 ABCE1/LSG1 2 GO:0001767 establishment of lymphocyte polarity 2/982 14/18722 0.165103135843403 0.468538532567461 GSN/FLOT2 2 GO:0001921 positive regulation of receptor recycling 2/982 14/18722 0.165103135843403 0.468538532567461 NSG1/ANXA2 2 GO:0002475 antigen processing and presentation via MHC class Ib 2/982 14/18722 0.165103135843403 0.468538532567461 B2M/HLA-E 2 GO:0002517 T cell tolerance induction 2/982 14/18722 0.165103135843403 0.468538532567461 HLA-B/PHLPP1 2 GO:0003188 heart valve formation 2/982 14/18722 0.165103135843403 0.468538532567461 GJA5/EFNA1 2 GO:0006047 UDP-N-acetylglucosamine metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 DPAGT1/GFPT1 2 GO:0006241 CTP biosynthetic process 2/982 14/18722 0.165103135843403 0.468538532567461 NME4/NME1 2 GO:0006521 regulation of cellular amino acid metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 COMT/CLN3 2 GO:0006596 polyamine biosynthetic process 2/982 14/18722 0.165103135843403 0.468538532567461 SMS/AZIN1 2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 2/982 14/18722 0.165103135843403 0.468538532567461 PRLR/EFNA5 2 GO:0010839 negative regulation of keratinocyte proliferation 2/982 14/18722 0.165103135843403 0.468538532567461 FGFR2/PTPRK 2 GO:0019321 pentose metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 RPIA/RPE 2 GO:0033750 ribosome localization 2/982 14/18722 0.165103135843403 0.468538532567461 ABCE1/LSG1 2 GO:0034111 negative regulation of homotypic cell-cell adhesion 2/982 14/18722 0.165103135843403 0.468538532567461 UBASH3B/C1QTNF1 2 GO:0035672 oligopeptide transmembrane transport 2/982 14/18722 0.165103135843403 0.468538532567461 GJA1/SLC13A3 2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/982 14/18722 0.165103135843403 0.468538532567461 LRP1/PDGFA 2 GO:0042415 norepinephrine metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 EPAS1/AKR1B1 2 GO:0043922 negative regulation by host of viral transcription 2/982 14/18722 0.165103135843403 0.468538532567461 TARDBP/CCL5 2 GO:0045579 positive regulation of B cell differentiation 2/982 14/18722 0.165103135843403 0.468538532567461 MMP14/BAD 2 GO:0046655 folic acid metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 SLC19A1/FOLR1 2 GO:0047484 regulation of response to osmotic stress 2/982 14/18722 0.165103135843403 0.468538532567461 CLN3/BAD 2 GO:0050667 homocysteine metabolic process 2/982 14/18722 0.165103135843403 0.468538532567461 COMT/TST 2 GO:0050872 white fat cell differentiation 2/982 14/18722 0.165103135843403 0.468538532567461 PPARG/CEBPA 2 GO:0051645 Golgi localization 2/982 14/18722 0.165103135843403 0.468538532567461 ARHGAP21/HOOK3 2 GO:0071285 cellular response to lithium ion 2/982 14/18722 0.165103135843403 0.468538532567461 CDH1/CEBPA 2 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 2/982 14/18722 0.165103135843403 0.468538532567461 TRIM28/DNMT1 2 GO:0097531 mast cell migration 2/982 14/18722 0.165103135843403 0.468538532567461 SWAP70/PGF 2 GO:0098734 macromolecule depalmitoylation 2/982 14/18722 0.165103135843403 0.468538532567461 ABHD12/LYPLA1 2 GO:1902969 mitotic DNA replication 2/982 14/18722 0.165103135843403 0.468538532567461 MCM2/BRCA2 2 GO:1905049 negative regulation of metallopeptidase activity 2/982 14/18722 0.165103135843403 0.468538532567461 LRP1/TIMP3 2 GO:2001171 positive regulation of ATP biosynthetic process 2/982 14/18722 0.165103135843403 0.468538532567461 TMSB4X/PINK1 2 GO:0001953 negative regulation of cell-matrix adhesion 4/982 41/18722 0.166285769580887 0.468538532567461 LRP1/RASA1/MMP14/MAP4K4 4 GO:0007099 centriole replication 4/982 41/18722 0.166285769580887 0.468538532567461 TRIM37/PLK2/CEP152/CEP135 4 GO:0010907 positive regulation of glucose metabolic process 4/982 41/18722 0.166285769580887 0.468538532567461 SORBS1/DDB1/PPP1R3E/IRS2 4 GO:0042307 positive regulation of protein import into nucleus 4/982 41/18722 0.166285769580887 0.468538532567461 CDH1/GLI3/TARDBP/TRIM28 4 GO:0051693 actin filament capping 4/982 41/18722 0.166285769580887 0.468538532567461 SCIN/TRIOBP/EPS8/GSN 4 GO:1905521 regulation of macrophage migration 4/982 41/18722 0.166285769580887 0.468538532567461 CD200/MMP14/PTK2/CCL5 4 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 3/982 27/18722 0.166359923756698 0.468538532567461 YES1/PTK2/VAV3 3 GO:0003272 endocardial cushion formation 3/982 27/18722 0.166359923756698 0.468538532567461 BMP7/TBX3/RBPJ 3 GO:0007026 negative regulation of microtubule depolymerization 3/982 27/18722 0.166359923756698 0.468538532567461 HDAC6/CAMSAP2/TPX2 3 GO:0008053 mitochondrial fusion 3/982 27/18722 0.166359923756698 0.468538532567461 TFRC/AFG3L2/HUWE1 3 GO:0010586 miRNA metabolic process 3/982 27/18722 0.166359923756698 0.468538532567461 KCNQ1OT1/LIN28B/HRAS 3 GO:0015813 L-glutamate transmembrane transport 3/982 27/18722 0.166359923756698 0.468538532567461 SLC25A13/SLC1A3/ITGB1 3 GO:0033561 regulation of water loss via skin 3/982 27/18722 0.166359923756698 0.468538532567461 MET/LSR/CLDN4 3 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 3/982 27/18722 0.166359923756698 0.468538532567461 YES1/PTK2/VAV3 3 GO:0039529 RIG-I signaling pathway 3/982 27/18722 0.166359923756698 0.468538532567461 PUM1/ZCCHC3/PUM2 3 GO:0042402 cellular biogenic amine catabolic process 3/982 27/18722 0.166359923756698 0.468538532567461 COMT/ALDH7A1/SLC44A1 3 GO:0070861 regulation of protein exit from endoplasmic reticulum 3/982 27/18722 0.166359923756698 0.468538532567461 TMEM30B/TM9SF4/INSIG1 3 GO:1903319 positive regulation of protein maturation 3/982 27/18722 0.166359923756698 0.468538532567461 SOX4/MMP14/GSN 3 GO:0071902 positive regulation of protein serine/threonine kinase activity 14/982 200/18722 0.167010015062035 0.470115617141703 EGFR/FZD10/DVL3/MAGED1/ALS2/FLT1/HRAS/CCND1/MAP3K7/CD24/FERMT2/PDGFA/MAP3K13/RICTOR 14 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 12/982 167/18722 0.167753486272288 0.471953713266587 TENM3/CDH1/DSC3/OBSL1/PCDH11X/DSG2/DSC2/CADM1/FAT1/PLXNB2/ITGB1/BSG 12 GO:0000281 mitotic cytokinesis 6/982 71/18722 0.167955238174644 0.47201213487012 MYH10/RASA1/RACGAP1/ANK3/STAMBP/KIF4A 6 GO:0033555 multicellular organismal response to stress 6/982 71/18722 0.167955238174644 0.47201213487012 GJA1/ADRB1/VWA1/ALS2/COMT/DPP4 6 GO:1903037 regulation of leukocyte cell-cell adhesion 22/982 336/18722 0.168104512946892 0.472177242612271 SOCS6/SOX4/TFRC/PAWR/IL6ST/GPAM/DLG5/B2M/TNFRSF21/CD46/HLA-A/NFAT5/GLI3/YES1/CD24/HLA-E/CCL5/DPP4/FLOT2/BAD/ASS1/BCL10 22 GO:0007596 blood coagulation 15/982 217/18722 0.168204468864153 0.472203718834997 F5/UBASH3B/GNA12/FBLN1/IL6ST/LMAN1/ANXA5/FZD6/C1QTNF1/PDGFA/CD59/HPS5/VAV3/ANXA2/F11R 15 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 5/982 56/18722 0.169228277493829 0.472787731873494 CADM1/B2M/HLA-B/HLA-A/HLA-E 5 GO:0002711 positive regulation of T cell mediated immunity 5/982 56/18722 0.169228277493829 0.472787731873494 B2M/HLA-B/HLA-A/MAP3K7/HLA-E 5 GO:0002886 regulation of myeloid leukocyte mediated immunity 5/982 56/18722 0.169228277493829 0.472787731873494 FER/SNX4/HLA-E/PDPK1/DDX1 5 GO:0015800 acidic amino acid transport 5/982 56/18722 0.169228277493829 0.472787731873494 GJA1/SLC25A13/SLC1A3/ITGB1/LRRC8D 5 GO:0042733 embryonic digit morphogenesis 5/982 56/18722 0.169228277493829 0.472787731873494 LRP5/FREM2/GLI3/FZD6/TBX3 5 GO:0051653 spindle localization 5/982 56/18722 0.169228277493829 0.472787731873494 GJA1/ASPM/WASL/SPDL1/ITGB1 5 GO:0051784 negative regulation of nuclear division 5/982 56/18722 0.169228277493829 0.472787731873494 BMP7/CENPF/ZWINT/SPDL1/LCMT1 5 GO:0090175 regulation of establishment of planar polarity 5/982 56/18722 0.169228277493829 0.472787731873494 DVL3/ZNRF3/DAB2/FZD6/NPHP3 5 GO:1904645 response to amyloid-beta 5/982 56/18722 0.169228277493829 0.472787731873494 GJA1/LRP1/APP/IGF1R/LGMN 5 GO:0002687 positive regulation of leukocyte migration 10/982 135/18722 0.17163037765974 0.479241996720129 APP/SWAP70/MMP14/PTN/JAM3/PTK2/CCL5/LGMN/CREB3/PGF 10 GO:0009895 negative regulation of catabolic process 21/982 320/18722 0.172209017543162 0.480600447033243 EGFR/MET/MGAT3/ALAD/EFNA1/TIMP3/AXIN2/TAB3/TARDBP/PINK1/NUPR1/CST3/DHX9/SLIRP/USP14/ANXA2/RRAGA/DFFA/USP25/AZIN1/PHF23 21 GO:0002833 positive regulation of response to biotic stimulus 12/982 168/18722 0.17264855156279 0.481312049680123 CADM1/TRIM6/MAP3K7/PUM1/HLA-E/ZCCHC3/CCL5/CYBA/PSPC1/PUM2/DHX9/GRN 12 GO:0099173 postsynapse organization 12/982 168/18722 0.17264855156279 0.481312049680123 NRP2/NRP1/SEMA3F/PTN/PPP1R9A/CTTN/IGF1R/EFNA1/WASL/ACTN1/HDAC6/LGMN 12 GO:2000116 regulation of cysteine-type endopeptidase activity 16/982 235/18722 0.173097022978526 0.482304525564098 PPARG/ASPH/PERP/DHCR24/IFI6/MDM2/TRIAP1/LGMN/BCL2L13/USP47/BIRC5/GSN/PRDX5/BAD/NLRP2/BCL10 16 GO:0030509 BMP signaling pathway 11/982 152/18722 0.175112766646065 0.487575418587942 LRP2/FBN1/BMP7/TGFBR3/PPARG/ACVR2B/DLX5/CRIM1/FSTL1/SMAD5/RBPJ 11 GO:0006631 fatty acid metabolic process 25/982 390/18722 0.175175677613843 0.487575418587942 SLC27A2/ATP6V1B1/ACSS1/ABHD12/PPARG/GPAM/DEGS1/ACADS/PTGES/HACD3/ACSF2/ECI1/CYP2J2/PPARD/ACADVL/SLC25A17/GSTP1/DECR2/INSIG1/ECHDC2/IRS2/AKR1B1/HSD17B12/LYPLA1/HADHB 25 GO:0030032 lamellipodium assembly 6/982 72/18722 0.17569982792453 0.488252691771096 FER/CYFIP1/NCKAP1/ITGB1/BIN3/VAV3 6 GO:0035567 non-canonical Wnt signaling pathway 6/982 72/18722 0.17569982792453 0.488252691771096 FZD10/DVL3/ZNRF3/DAB2/FZD6/NPHP3 6 GO:0071479 cellular response to ionizing radiation 6/982 72/18722 0.17569982792453 0.488252691771096 NET1/YAP1/HRAS/MDM2/CYBA/ATR 6 GO:0010591 regulation of lamellipodium assembly 4/982 42/18722 0.176703060595226 0.488438348735928 FER/CYFIP1/NCKAP1/BIN3 4 GO:0021879 forebrain neuron differentiation 4/982 42/18722 0.176703060595226 0.488438348735928 NRP2/FGFR2/NRP1/B2M 4 GO:0030890 positive regulation of B cell proliferation 4/982 42/18722 0.176703060595226 0.488438348735928 TFRC/SLC39A10/VAV3/IRS2 4 GO:0043507 positive regulation of JUN kinase activity 4/982 42/18722 0.176703060595226 0.488438348735928 FZD10/DVL3/MAP3K7/MAP3K13 4 GO:0045687 positive regulation of glial cell differentiation 4/982 42/18722 0.176703060595226 0.488438348735928 DAG1/SPINT1/IL6ST/PTN 4 GO:0045773 positive regulation of axon extension 4/982 42/18722 0.176703060595226 0.488438348735928 LRP1/NRP1/CYFIP1/MAP3K13 4 GO:0071312 cellular response to alkaloid 4/982 42/18722 0.176703060595226 0.488438348735928 SLC1A3/TGM2/MDM2/CCNA2 4 GO:0072595 maintenance of protein localization in organelle 4/982 42/18722 0.176703060595226 0.488438348735928 GJA1/PINK1/INSIG1/GPAA1 4 GO:1900274 regulation of phospholipase C activity 4/982 42/18722 0.176703060595226 0.488438348735928 EGFR/FLT1/HRAS/P2RY6 4 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 4/982 42/18722 0.176703060595226 0.488438348735928 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0034764 positive regulation of transmembrane transport 15/982 219/18722 0.176805743689995 0.488463325787614 TCAF1/SORBS1/WNK2/TMSB4X/PRKCI/KCNN4/P2RY6/PINK1/ITGB1/ANK3/IRS2/OPN3/EHD3/PDPK1/AZIN1 15 GO:0045727 positive regulation of translation 10/982 136/18722 0.17718351283378 0.489247857565378 SOX4/EIF2AK4/PLXNB2/YTHDF2/CCL5/PINK1/DHX9/METTL3/UPF3A/VIM 10 GO:0097305 response to alcohol 17/982 253/18722 0.177409265325674 0.489612025364399 DAG1/CDH1/FGFR2/TGFBR3/LRP6/GNAI1/ALAD/ATP2B1/CCND1/EPS8/P2RY6/SPARC/MDM2/CYBA/GSTP1/CDO1/BAD 17 GO:0031214 biomineral tissue development 12/982 169/18722 0.177612739797461 0.489914357897174 FBN2/LGR4/FGFR2/BMP7/SLC4A2/PTN/NOTUM/ACVR2B/FAM83H/ATP2B1/TFAP2A/AXIN2 12 GO:0009144 purine nucleoside triphosphate metabolic process 7/982 88/18722 0.178561940119993 0.491832324100643 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/ADK/NME1 7 GO:0007052 mitotic spindle organization 9/982 120/18722 0.178671769954078 0.491832324100643 TACC2/GNAI1/EML1/RACGAP1/CLTC/PLK2/TPX2/DCTN6/KIF4A 9 GO:0030218 erythrocyte differentiation 9/982 120/18722 0.178671769954078 0.491832324100643 TGFBR3/EPAS1/B2M/RCOR1/SLC11A2/CDK6/UBA5/SMAD5/ALAS1 9 GO:0002507 tolerance induction 3/982 28/18722 0.179533885177842 0.491832324100643 HLA-B/HLA-E/PHLPP1 3 GO:0006972 hyperosmotic response 3/982 28/18722 0.179533885177842 0.491832324100643 SLC2A1/AKR1B1/PDPK1 3 GO:0008299 isoprenoid biosynthetic process 3/982 28/18722 0.179533885177842 0.491832324100643 RDH10/PDSS2/MVK 3 GO:0030262 apoptotic nuclear changes 3/982 28/18722 0.179533885177842 0.491832324100643 BLCAP/TOP2A/DFFA 3 GO:0031342 negative regulation of cell killing 3/982 28/18722 0.179533885177842 0.491832324100643 HLA-B/HLA-A/HLA-E 3 GO:0038094 Fc-gamma receptor signaling pathway 3/982 28/18722 0.179533885177842 0.491832324100643 YES1/PTK2/VAV3 3 GO:0042983 amyloid precursor protein biosynthetic process 3/982 28/18722 0.179533885177842 0.491832324100643 PAWR/BACE2/ITM2C 3 GO:0042984 regulation of amyloid precursor protein biosynthetic process 3/982 28/18722 0.179533885177842 0.491832324100643 PAWR/BACE2/ITM2C 3 GO:0051894 positive regulation of focal adhesion assembly 3/982 28/18722 0.179533885177842 0.491832324100643 NRP1/FERMT2/MAP4K4 3 GO:1903779 regulation of cardiac conduction 3/982 28/18722 0.179533885177842 0.491832324100643 GJA5/ATP2B1/EHD3 3 GO:0097529 myeloid leukocyte migration 15/982 220/18722 0.181187626084212 0.493539671965936 CD200/CSF3R/SWAP70/MMP14/JAM3/FLT1/PTK2/CCL5/MPP1/LGMN/VAV3/DPP4/CREB3/BSG/PGF 15 GO:0006753 nucleoside phosphate metabolic process 31/982 497/18722 0.181469046483279 0.493539671965936 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TK1/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/QPRT/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/DTYMK/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC/RRM1 31 GO:0033673 negative regulation of kinase activity 16/982 237/18722 0.181489016568539 0.493539671965936 NR2F2/LRP5/BMP7/UBASH3B/PPARG/NF1/LRP6/LATS2/CDKN1C/CEBPA/MLLT1/PKIB/GSTP1/IRS2/TRIM27/PDPK1 16 GO:0006986 response to unfolded protein 10/982 137/18722 0.182819182015798 0.493539671965936 SERPINH1/WFS1/DNAJB4/HSPA4L/CCND1/TMEM33/TM7SF3/CREB3L2/CREB3/FAF2 10 GO:0060048 cardiac muscle contraction 10/982 137/18722 0.182819182015798 0.493539671965936 GJA1/GJA5/DSG2/DSP/DSC2/GAA/PKP2/GSN/SMAD5/EHD3 10 GO:0051298 centrosome duplication 6/982 73/18722 0.183586833090584 0.493539671965936 TRIM37/PLK2/BRCA2/CEP152/SAC3D1/CEP135 6 GO:0000722 telomere maintenance via recombination 2/982 15/18722 0.184225793964279 0.493539671965936 BRCA2/RAD50 2 GO:0006098 pentose-phosphate shunt 2/982 15/18722 0.184225793964279 0.493539671965936 RPIA/RPE 2 GO:0009163 nucleoside biosynthetic process 2/982 15/18722 0.184225793964279 0.493539671965936 DTYMK/ADK 2 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 2/982 15/18722 0.184225793964279 0.493539671965936 NME4/NME1 2 GO:0010713 negative regulation of collagen metabolic process 2/982 15/18722 0.184225793964279 0.493539671965936 PPARD/CST3 2 GO:0010763 positive regulation of fibroblast migration 2/982 15/18722 0.184225793964279 0.493539671965936 PTK2/ITGB1 2 GO:0010889 regulation of sequestering of triglyceride 2/982 15/18722 0.184225793964279 0.493539671965936 PPARG/PNPLA2 2 GO:0018410 C-terminal protein amino acid modification 2/982 15/18722 0.184225793964279 0.493539671965936 WIPI2/LCMT1 2 GO:0019511 peptidyl-proline hydroxylation 2/982 15/18722 0.184225793964279 0.493539671965936 P4HB/PRDX4 2 GO:0032239 regulation of nucleobase-containing compound transport 2/982 15/18722 0.184225793964279 0.493539671965936 DHX9/NUP153 2 GO:0032354 response to follicle-stimulating hormone 2/982 15/18722 0.184225793964279 0.493539671965936 TGFBR3/GCLM 2 GO:0034404 nucleobase-containing small molecule biosynthetic process 2/982 15/18722 0.184225793964279 0.493539671965936 DTYMK/ADK 2 GO:0035627 ceramide transport 2/982 15/18722 0.184225793964279 0.493539671965936 PLEKHA8/PSAP 2 GO:0042074 cell migration involved in gastrulation 2/982 15/18722 0.184225793964279 0.493539671965936 LRP5/AMOT 2 GO:0042249 establishment of planar polarity of embryonic epithelium 2/982 15/18722 0.184225793964279 0.493539671965936 DVL3/NPHP3 2 GO:0042976 activation of Janus kinase activity 2/982 15/18722 0.184225793964279 0.493539671965936 PRLR/CCL5 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/982 15/18722 0.184225793964279 0.493539671965936 MDM2/PTTG1IP 2 GO:0045475 locomotor rhythm 2/982 15/18722 0.184225793964279 0.493539671965936 NAGLU/ZFHX3 2 GO:0046321 positive regulation of fatty acid oxidation 2/982 15/18722 0.184225793964279 0.493539671965936 PPARD/IRS2 2 GO:0046459 short-chain fatty acid metabolic process 2/982 15/18722 0.184225793964279 0.493539671965936 ACSS1/ACADS 2 GO:0051938 L-glutamate import 2/982 15/18722 0.184225793964279 0.493539671965936 SLC1A3/ITGB1 2 GO:0060026 convergent extension 2/982 15/18722 0.184225793964279 0.493539671965936 NPHP3/TRIM28 2 GO:0060413 atrial septum morphogenesis 2/982 15/18722 0.184225793964279 0.493539671965936 ISL1/SOX4 2 GO:0070831 basement membrane assembly 2/982 15/18722 0.184225793964279 0.493539671965936 LAMB1/DAG1 2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 2/982 15/18722 0.184225793964279 0.493539671965936 TMEM30B/TM9SF4 2 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 2/982 15/18722 0.184225793964279 0.493539671965936 ABCE1/LSG1 2 GO:0071474 cellular hyperosmotic response 2/982 15/18722 0.184225793964279 0.493539671965936 SLC2A1/AKR1B1 2 GO:0071599 otic vesicle development 2/982 15/18722 0.184225793964279 0.493539671965936 FGFR2/AHI1 2 GO:0072075 metanephric mesenchyme development 2/982 15/18722 0.184225793964279 0.493539671965936 BMP7/BASP1 2 GO:0098712 L-glutamate import across plasma membrane 2/982 15/18722 0.184225793964279 0.493539671965936 SLC1A3/ITGB1 2 GO:0099170 postsynaptic modulation of chemical synaptic transmission 2/982 15/18722 0.184225793964279 0.493539671965936 CDH1/CYFIP1 2 GO:0150011 regulation of neuron projection arborization 2/982 15/18722 0.184225793964279 0.493539671965936 DVL3/MAP3K13 2 GO:1902018 negative regulation of cilium assembly 2/982 15/18722 0.184225793964279 0.493539671965936 YAP1/LIMK2 2 GO:1903729 regulation of plasma membrane organization 2/982 15/18722 0.184225793964279 0.493539671965936 WASL/GSN 2 GO:1905288 vascular associated smooth muscle cell apoptotic process 2/982 15/18722 0.184225793964279 0.493539671965936 PPARG/DNMT1 2 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 2/982 15/18722 0.184225793964279 0.493539671965936 PPARG/DNMT1 2 GO:2000402 negative regulation of lymphocyte migration 2/982 15/18722 0.184225793964279 0.493539671965936 CD200/WASL 2 GO:0050770 regulation of axonogenesis 11/982 154/18722 0.185740988217006 0.497343426355187 PLXNB1/SEMA6D/SEMA6A/LRP1/NRP1/SEMA3F/SEMA4C/CYFIP1/EFNA1/PLXNB2/MAP3K13 11 GO:0006826 iron ion transport 5/982 58/18722 0.187109132961193 0.498793181424186 TFRC/B2M/SLC40A1/SLC11A2/CLTC 5 GO:0018208 peptidyl-proline modification 5/982 58/18722 0.187109132961193 0.498793181424186 FKBP9/PPIC/P4HB/PRDX4/RANBP2 5 GO:0043506 regulation of JUN kinase activity 5/982 58/18722 0.187109132961193 0.498793181424186 FZD10/DVL3/MAP3K7/MAP3K13/GSTP1 5 GO:0001504 neurotransmitter uptake 4/982 43/18722 0.18733432561541 0.498793181424186 SLC6A4/SLC1A3/SLC29A1/ITGB1 4 GO:0009268 response to pH 4/982 43/18722 0.18733432561541 0.498793181424186 GJA1/GNA11/SERPINF1/LGMN 4 GO:0016266 O-glycan processing 4/982 43/18722 0.18733432561541 0.498793181424186 B3GNT5/GXYLT1/GALNT11/B3GNT3 4 GO:0033046 negative regulation of sister chromatid segregation 4/982 43/18722 0.18733432561541 0.498793181424186 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0033048 negative regulation of mitotic sister chromatid segregation 4/982 43/18722 0.18733432561541 0.498793181424186 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0120178 steroid hormone biosynthetic process 4/982 43/18722 0.18733432561541 0.498793181424186 ADM/HSD17B1/AKR1B1/HSD17B12 4 GO:1904591 positive regulation of protein import 4/982 43/18722 0.18733432561541 0.498793181424186 CDH1/GLI3/TARDBP/TRIM28 4 GO:2000816 negative regulation of mitotic sister chromatid separation 4/982 43/18722 0.18733432561541 0.498793181424186 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0110148 biomineralization 12/982 171/18722 0.187743937775657 0.4996287650193 FBN2/LGR4/FGFR2/BMP7/SLC4A2/PTN/NOTUM/ACVR2B/FAM83H/ATP2B1/TFAP2A/AXIN2 12 GO:0030308 negative regulation of cell growth 13/982 188/18722 0.189043069105315 0.502678263002273 GJA1/SEMA6D/SEMA6A/SH3BP4/NRP1/DCBLD2/SEMA3F/SERTAD3/SEMA4C/SMARCA2/PPARD/SERTAD2/VGLL4 13 GO:0001933 negative regulation of protein phosphorylation 22/982 342/18722 0.189082582824091 0.502678263002273 PLPP3/NR2F2/LRP1/LRP5/BMP7/UBASH3B/FBLN1/PPARG/NF1/LRP6/LATS2/CDKN1C/CTDSPL/PARD3/CEBPA/TARDBP/MLLT1/PKIB/DUSP6/GSTP1/TRIM27/PDPK1 22 GO:0007599 hemostasis 15/982 222/18722 0.190110292149177 0.504895765707795 F5/UBASH3B/GNA12/FBLN1/IL6ST/LMAN1/ANXA5/FZD6/C1QTNF1/PDGFA/CD59/HPS5/VAV3/ANXA2/F11R 15 GO:0050817 coagulation 15/982 222/18722 0.190110292149177 0.504895765707795 F5/UBASH3B/GNA12/FBLN1/IL6ST/LMAN1/ANXA5/FZD6/C1QTNF1/PDGFA/CD59/HPS5/VAV3/ANXA2/F11R 15 GO:0006606 protein import into nucleus 11/982 155/18722 0.191164329921576 0.507436714947044 CDH1/FERMT1/HEATR3/GLI3/TNPO1/TARDBP/LMNA/NUP153/RANBP2/PTTG1IP/TRIM28 11 GO:0009201 ribonucleoside triphosphate biosynthetic process 6/982 74/18722 0.191610646138339 0.507846102773159 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/NME1 6 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 6/982 74/18722 0.191610646138339 0.507846102773159 SKP2/ISL1/YAP1/DAB2/HDAC6/UBA5 6 GO:1903201 regulation of oxidative stress-induced cell death 6/982 74/18722 0.191610646138339 0.507846102773159 MET/PAWR/PAGE4/HDAC6/P4HB/PINK1 6 GO:0019882 antigen processing and presentation 8/982 106/18722 0.192477796496069 0.507857973554293 CTSV/B2M/CTSL/HLA-B/HLA-A/HLA-C/HLA-E/LGMN 8 GO:0000305 response to oxygen radical 3/982 29/18722 0.192978240717908 0.507857973554293 BMP7/PRDX1/TXNRD2 3 GO:0002068 glandular epithelial cell development 3/982 29/18722 0.192978240717908 0.507857973554293 CDK6/BAD/PDPK1 3 GO:0003309 type B pancreatic cell differentiation 3/982 29/18722 0.192978240717908 0.507857973554293 CDK6/BAD/PDPK1 3 GO:0005979 regulation of glycogen biosynthetic process 3/982 29/18722 0.192978240717908 0.507857973554293 SORBS1/PPP1R3E/IRS2 3 GO:0009310 amine catabolic process 3/982 29/18722 0.192978240717908 0.507857973554293 COMT/ALDH7A1/SLC44A1 3 GO:0010962 regulation of glucan biosynthetic process 3/982 29/18722 0.192978240717908 0.507857973554293 SORBS1/PPP1R3E/IRS2 3 GO:0015701 bicarbonate transport 3/982 29/18722 0.192978240717908 0.507857973554293 SLC26A2/SLC4A2/CYB5R1 3 GO:0048665 neuron fate specification 3/982 29/18722 0.192978240717908 0.507857973554293 ISL1/ESRP1/GLI3 3 GO:0060969 negative regulation of gene silencing 3/982 29/18722 0.192978240717908 0.507857973554293 KCNQ1OT1/LIN28B/PPARG 3 GO:0062098 regulation of programmed necrotic cell death 3/982 29/18722 0.192978240717908 0.507857973554293 SPATA2/SLC25A4/NUPR1 3 GO:0071549 cellular response to dexamethasone stimulus 3/982 29/18722 0.192978240717908 0.507857973554293 EGFR/SERPINF1/ASS1 3 GO:0090025 regulation of monocyte chemotaxis 3/982 29/18722 0.192978240717908 0.507857973554293 CCL5/LGMN/CREB3 3 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/982 29/18722 0.192978240717908 0.507857973554293 MDM2/TRIAP1/PTTG1IP 3 GO:0001836 release of cytochrome c from mitochondria 5/982 59/18722 0.196295573180378 0.516067394006476 IFI6/TRIAP1/PINK1/LMNA/BAD 5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 5/982 59/18722 0.196295573180378 0.516067394006476 SOCS6/SOCS7/FLT1/PTK2/VAV3 5 GO:0043270 positive regulation of ion transport 18/982 275/18722 0.197406664436106 0.518108426192096 SLC6A4/TCAF1/WNK2/TMSB4X/PRSS8/WFS1/ATP2B1/PTGES/SNX4/KCNN4/P2RY6/CCL5/PINK1/ITGB1/PKP2/ANK3/EHD3/PDPK1 18 GO:0006694 steroid biosynthetic process 12/982 173/18722 0.198137525505281 0.518108426192096 PBX1/PRLR/SLC27A2/ADM/SQLE/CYB5R1/HSD17B1/DHCR24/MVK/INSIG1/AKR1B1/HSD17B12 12 GO:0005978 glycogen biosynthetic process 4/982 44/18722 0.198164553346095 0.518108426192096 SORBS1/AGL/PPP1R3E/IRS2 4 GO:0009250 glucan biosynthetic process 4/982 44/18722 0.198164553346095 0.518108426192096 SORBS1/AGL/PPP1R3E/IRS2 4 GO:0042269 regulation of natural killer cell mediated cytotoxicity 4/982 44/18722 0.198164553346095 0.518108426192096 CADM1/HLA-B/HLA-A/HLA-E 4 GO:0045124 regulation of bone resorption 4/982 44/18722 0.198164553346095 0.518108426192096 EGFR/TFRC/UBASH3B/NF1 4 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 4/982 44/18722 0.198164553346095 0.518108426192096 DLG5/FAT1/PRKCI/PARD3 4 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 4/982 44/18722 0.198164553346095 0.518108426192096 PRLR/IL10RB/CCL5/AKR1B1 4 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 4/982 44/18722 0.198164553346095 0.518108426192096 PUM1/ZCCHC3/CYBA/PUM2 4 GO:1903214 regulation of protein targeting to mitochondrion 4/982 44/18722 0.198164553346095 0.518108426192096 LMAN1/PINK1/LEPROT/HUWE1 4 GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/982 44/18722 0.198164553346095 0.518108426192096 WFS1/CREB3/USP14/USP25 4 GO:0008637 apoptotic mitochondrial changes 8/982 107/18722 0.199221124135369 0.520088780525568 SLC25A4/IFI6/TRIAP1/PINK1/LMNA/PPP2CB/GCLM/BAD 8 GO:0010927 cellular component assembly involved in morphogenesis 8/982 107/18722 0.199221124135369 0.520088780525568 ITGB4/DAG1/OBSL1/GPC1/CSRP2/ITGB1/EPB41L3/KRT8 8 GO:0036503 ERAD pathway 8/982 107/18722 0.199221124135369 0.520088780525568 UGGT2/WFS1/UBE4B/TMUB1/HSP90B1/USP14/FAF2/USP25 8 GO:0008088 axo-dendritic transport 6/982 75/18722 0.19976551295338 0.520728093735547 DST/APP/HDAC6/ARMCX3/FLOT2/KIF4A 6 GO:0045913 positive regulation of carbohydrate metabolic process 6/982 75/18722 0.19976551295338 0.520728093735547 APP/SORBS1/DDB1/PPP1R3E/P2RY6/IRS2 6 GO:1903363 negative regulation of cellular protein catabolic process 6/982 75/18722 0.19976551295338 0.520728093735547 MGAT3/ALAD/EFNA1/USP14/ANXA2/USP25 6 GO:0042147 retrograde transport, endosome to Golgi 7/982 91/18722 0.200330559995165 0.521679581095746 RHOBTB3/EVI5/TMEM87A/CLTC/DENND5A/EHD3/TRIM27 7 GO:0051983 regulation of chromosome segregation 7/982 91/18722 0.200330559995165 0.521679581095746 CENPF/ZWINT/PUM1/SPDL1/RMI2/PUM2/LCMT1 7 GO:0002262 myeloid cell homeostasis 11/982 157/18722 0.202221977286322 0.522474958670677 TGFBR3/EPAS1/JAM3/B2M/RCOR1/SLC11A2/CDK6/UBA5/PRDX1/SMAD5/ALAS1 11 GO:0009132 nucleoside diphosphate metabolic process 9/982 124/18722 0.203408103880017 0.522474958670677 APP/TJP2/MPP1/NUPR1/NME4/DHTKD1/DTYMK/BAD/NME1 9 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/982 16/18722 0.203641025877586 0.522474958670677 ENPEP/MME 2 GO:0002921 negative regulation of humoral immune response 2/982 16/18722 0.203641025877586 0.522474958670677 CD46/CD59 2 GO:0003084 positive regulation of systemic arterial blood pressure 2/982 16/18722 0.203641025877586 0.522474958670677 NR2F2/CYBA 2 GO:0005980 glycogen catabolic process 2/982 16/18722 0.203641025877586 0.522474958670677 GAA/AGL 2 GO:0006004 fucose metabolic process 2/982 16/18722 0.203641025877586 0.522474958670677 FUT8/FUCA1 2 GO:0006544 glycine metabolic process 2/982 16/18722 0.203641025877586 0.522474958670677 GLDC/GCSH 2 GO:0006740 NADPH regeneration 2/982 16/18722 0.203641025877586 0.522474958670677 RPIA/RPE 2 GO:0006750 glutathione biosynthetic process 2/982 16/18722 0.203641025877586 0.522474958670677 GSS/GCLM 2 GO:0006857 oligopeptide transport 2/982 16/18722 0.203641025877586 0.522474958670677 GJA1/SLC13A3 2 GO:0009415 response to water 2/982 16/18722 0.203641025877586 0.522474958670677 AKR1B1/KRT8 2 GO:0010225 response to UV-C 2/982 16/18722 0.203641025877586 0.522474958670677 MDM2/BRCA2 2 GO:0019081 viral translation 2/982 16/18722 0.203641025877586 0.522474958670677 EIF2AK4/DHX9 2 GO:0019377 glycolipid catabolic process 2/982 16/18722 0.203641025877586 0.522474958670677 FUCA1/NEU1 2 GO:0032274 gonadotropin secretion 2/982 16/18722 0.203641025877586 0.522474958670677 GJA1/TBX3 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/982 16/18722 0.203641025877586 0.522474958670677 BMP7/GCNT2 2 GO:0035751 regulation of lysosomal lumen pH 2/982 16/18722 0.203641025877586 0.522474958670677 CLN3/GRN 2 GO:0035970 peptidyl-threonine dephosphorylation 2/982 16/18722 0.203641025877586 0.522474958670677 DUSP5/PPP2CB 2 GO:0042407 cristae formation 2/982 16/18722 0.203641025877586 0.522474958670677 PINK1/AFG3L2 2 GO:0045838 positive regulation of membrane potential 2/982 16/18722 0.203641025877586 0.522474958670677 ANK3/BAD 2 GO:0046036 CTP metabolic process 2/982 16/18722 0.203641025877586 0.522474958670677 NME4/NME1 2 GO:0048557 embryonic digestive tract morphogenesis 2/982 16/18722 0.203641025877586 0.522474958670677 FGFR2/GLI3 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/982 16/18722 0.203641025877586 0.522474958670677 KCNN4/BCL10 2 GO:0050884 neuromuscular process controlling posture 2/982 16/18722 0.203641025877586 0.522474958670677 TMEM150C/GAA 2 GO:0051014 actin filament severing 2/982 16/18722 0.203641025877586 0.522474958670677 SCIN/GSN 2 GO:0099633 protein localization to postsynaptic specialization membrane 2/982 16/18722 0.203641025877586 0.522474958670677 DAG1/HRAS 2 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 2/982 16/18722 0.203641025877586 0.522474958670677 DAG1/HRAS 2 GO:1905906 regulation of amyloid fibril formation 2/982 16/18722 0.203641025877586 0.522474958670677 APP/LDLR 2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 2/982 16/18722 0.203641025877586 0.522474958670677 WNK2/ANK3 2 GO:0030099 myeloid cell differentiation 24/982 381/18722 0.203827174501307 0.522695448475329 FBN1/APP/SCIN/CSF3R/TFRC/UBASH3B/TGFBR3/PPARG/ITGB8/EPAS1/B2M/RCOR1/ACTN1/CEBPA/TET2/SLC11A2/ESRRA/CDK6/UBA5/SMAD5/ALAS1/ANXA2/NME1/RBPJ 24 GO:0050863 regulation of T cell activation 21/982 329/18722 0.205444865214147 0.52429477090698 SOCS6/SOX4/TFRC/PAWR/IL6ST/GPAM/DLG5/B2M/TNFRSF21/CD46/HLA-A/GLI3/YES1/CD24/HLA-E/CCL5/METTL3/DPP4/FLOT2/BAD/BCL10 21 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 5/982 60/18722 0.205634236964601 0.52429477090698 MAP3K7/PUM1/ZCCHC3/TSPAN6/PUM2 5 GO:0033866 nucleoside bisphosphate biosynthetic process 5/982 60/18722 0.205634236964601 0.52429477090698 SLC26A2/ACSS1/SLC25A1/SLC35B2/HSD17B12 5 GO:0034030 ribonucleoside bisphosphate biosynthetic process 5/982 60/18722 0.205634236964601 0.52429477090698 SLC26A2/ACSS1/SLC25A1/SLC35B2/HSD17B12 5 GO:0034033 purine nucleoside bisphosphate biosynthetic process 5/982 60/18722 0.205634236964601 0.52429477090698 SLC26A2/ACSS1/SLC25A1/SLC35B2/HSD17B12 5 GO:0042306 regulation of protein import into nucleus 5/982 60/18722 0.205634236964601 0.52429477090698 CDH1/FERMT1/GLI3/TARDBP/TRIM28 5 GO:0002832 negative regulation of response to biotic stimulus 8/982 108/18722 0.206058952547232 0.52429477090698 PPARG/HLA-B/HLA-A/HLA-E/YTHDF2/TSPAN6/GRN/METTL3 8 GO:0016241 regulation of macroautophagy 10/982 141/18722 0.206151299244902 0.52429477090698 ATP6V1B1/SLC25A4/MAP3K7/CLN3/HDAC6/PINK1/NUPR1/ATP6V1H/ATP6V1C2/PHF23 10 GO:0048284 organelle fusion 10/982 141/18722 0.206151299244902 0.52429477090698 SYT7/TFRC/ANKRD27/RAB13/CLN3/TBC1D4/AFG3L2/VAV3/ANXA2/HUWE1 10 GO:0000132 establishment of mitotic spindle orientation 3/982 30/18722 0.206662202642782 0.52429477090698 GJA1/SPDL1/ITGB1 3 GO:0006221 pyrimidine nucleotide biosynthetic process 3/982 30/18722 0.206662202642782 0.52429477090698 NME4/DTYMK/NME1 3 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 3/982 30/18722 0.206662202642782 0.52429477090698 BLCAP/TOP2A/DFFA 3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/982 30/18722 0.206662202642782 0.52429477090698 APP/BMP7/TRIM6 3 GO:0030204 chondroitin sulfate metabolic process 3/982 30/18722 0.206662202642782 0.52429477090698 CHPF/DSEL/XYLT1 3 GO:0034390 smooth muscle cell apoptotic process 3/982 30/18722 0.206662202642782 0.52429477090698 PPARG/LRP6/DNMT1 3 GO:0034391 regulation of smooth muscle cell apoptotic process 3/982 30/18722 0.206662202642782 0.52429477090698 PPARG/LRP6/DNMT1 3 GO:0043304 regulation of mast cell degranulation 3/982 30/18722 0.206662202642782 0.52429477090698 FER/SNX4/PDPK1 3 GO:0046825 regulation of protein export from nucleus 3/982 30/18722 0.206662202642782 0.52429477090698 PTPN14/MDM2/TCF7L2 3 GO:0051491 positive regulation of filopodium assembly 3/982 30/18722 0.206662202642782 0.52429477090698 NRP1/WASL/FNBP1L 3 GO:0060218 hematopoietic stem cell differentiation 3/982 30/18722 0.206662202642782 0.52429477090698 YTHDF2/METTL3/FOXC1 3 GO:0060292 long-term synaptic depression 3/982 30/18722 0.206662202642782 0.52429477090698 SHANK2/PPP1R9A/PLK2 3 GO:1903019 negative regulation of glycoprotein metabolic process 3/982 30/18722 0.206662202642782 0.52429477090698 CST3/BACE2/ITM2C 3 GO:0006497 protein lipidation 7/982 92/18722 0.20780691884802 0.526779410690774 PGAP2/PGAP1/WIPI2/PIGU/PIGF/ZDHHC3/GPAA1 7 GO:0001937 negative regulation of endothelial cell proliferation 6/982 76/18722 0.208045549467599 0.526779410690774 GJA1/NR2F2/PPARG/NF1/FLT1/SPARC 6 GO:0021536 diencephalon development 6/982 76/18722 0.208045549467599 0.526779410690774 CDH1/NRP2/ISL1/NRP1/PTN/RBPJ 6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 6/982 76/18722 0.208045549467599 0.526779410690774 PERP/MDM2/TRIAP1/NUPR1/BRCA2/PTTG1IP 6 GO:0071241 cellular response to inorganic substance 15/982 226/18722 0.208569323312397 0.527849388839137 CDH1/EGFR/APP/SYT7/B2M/ALAD/SERPINF1/TFAP2A/HSD17B1/CEBPA/LGMN/ANK3/CLIC4/BAD/CCNA2 15 GO:0032872 regulation of stress-activated MAPK cascade 13/982 192/18722 0.209129073408761 0.527854810850997 EGFR/APP/SEMA4C/TRAF4/MARVELD3/IGF1R/HRAS/PAGE4/PHLPP1/PINK1/MAP4K4/PRDX1/GSTP1 13 GO:0003254 regulation of membrane depolarization 4/982 45/18722 0.209178660665071 0.527854810850997 GJA5/IFI6/ANK3/GCLM 4 GO:0006903 vesicle targeting 4/982 45/18722 0.209178660665071 0.527854810850997 TFG/AP1M2/TRIP11/TMED9 4 GO:0051985 negative regulation of chromosome segregation 4/982 45/18722 0.209178660665071 0.527854810850997 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0098534 centriole assembly 4/982 45/18722 0.209178660665071 0.527854810850997 TRIM37/PLK2/CEP152/CEP135 4 GO:1905819 negative regulation of chromosome separation 4/982 45/18722 0.209178660665071 0.527854810850997 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0009117 nucleotide metabolic process 30/982 489/18722 0.211035526139065 0.532283029178608 SLC26A2/APP/ACSS1/SLC25A13/GPAM/TMSB4X/ADSL/TJP2/NUDT4/ACSF2/MVK/QPRT/SLC25A1/PINK1/MPP1/SLC35B2/NUPR1/NME4/DHTKD1/PPAT/DTYMK/IMPDH2/SUCLA2/PDE7A/HSD17B12/ADK/BAD/NME1/ATIC/RRM1 30 GO:0046467 membrane lipid biosynthetic process 10/982 142/18722 0.212172176659044 0.534891287314439 PLPP3/PGAP2/PGAP1/B3GNT5/PIGU/DEGS1/HACD3/PIGF/GPAA1/SPTLC3 10 GO:0051170 import into nucleus 11/982 159/18722 0.213550329223901 0.53810556388013 CDH1/FERMT1/HEATR3/GLI3/TNPO1/TARDBP/LMNA/NUP153/RANBP2/PTTG1IP/TRIM28 11 GO:0002685 regulation of leukocyte migration 14/982 210/18722 0.213964394511723 0.538888595737879 CD200/APP/SWAP70/MMP14/PTN/JAM3/WASL/PTK2/CCL5/MPP1/LGMN/DPP4/CREB3/PGF 14 GO:0050728 negative regulation of inflammatory response 12/982 176/18722 0.214197265697549 0.539194253587207 CD200/ISL1/PPARG/LDLR/SERPINF1/YES1/MVK/PPARD/GSTP1/GRN/PLK2/FEM1A 12 GO:0001935 endothelial cell proliferation 13/982 193/18722 0.214292501473597 0.539194253587207 GJA1/NR2F2/NRP2/NRP1/MMP14/PPARG/NF1/FLT1/SPARC/CYBA/RICTOR/PGF/PDPK1 13 GO:0046394 carboxylic acid biosynthetic process 20/982 314/18722 0.215079169060184 0.540744920596881 SLC27A2/PLOD2/ACSS1/PSAT1/SLC1A3/RDH10/MGST3/DEGS1/PTGES/HACD3/CLN3/ACADVL/ASNSD1/AASDHPPT/GSTP1/DECR2/INSIG1/SUCLA2/HSD17B12/ASS1 20 GO:0090342 regulation of cell aging 5/982 61/18722 0.215116125429166 0.540744920596881 PAWR/B2M/CDK6/LMNA/PLK2 5 GO:0097306 cellular response to alcohol 7/982 93/18722 0.215386311070078 0.540902743640601 DAG1/CDH1/LRP6/GNAI1/ATP2B1/P2RY6/MDM2 7 GO:1901796 regulation of signal transduction by p53 class mediator 7/982 93/18722 0.215386311070078 0.540902743640601 RPF2/MDM2/TRIM24/TRIAP1/ATR/PTTG1IP/KMT5A 7 GO:0055117 regulation of cardiac muscle contraction 6/982 77/18722 0.216444758024714 0.543299257871466 GJA5/DSG2/DSP/DSC2/PKP2/EHD3 6 GO:0070663 regulation of leukocyte proliferation 16/982 245/18722 0.216990170413821 0.544406314996868 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/PTK2/CD24/HLA-E/CCL5/GSTP1/VAV3/IRS2 16 GO:0042326 negative regulation of phosphorylation 24/982 385/18722 0.218319485644964 0.545458349921397 PLPP3/NR2F2/LRP1/LRP5/BMP7/UBASH3B/FBLN1/PPARG/NF1/LRP6/LATS2/CDKN1C/CTDSPL/PARD3/CEBPA/TARDBP/MLLT1/PKIB/DUSP6/NUPR1/GSTP1/IRS2/TRIM27/PDPK1 24 GO:0030100 regulation of endocytosis 14/982 211/18722 0.218954519818226 0.545458349921397 ITGAV/LRP1/PROM2/B2M/DAB2/SYNJ1/WASL/CLN3/PACSIN2/RAB31/AHI1/CD2AP/RAB17/ANXA2 14 GO:0042180 cellular ketone metabolic process 14/982 211/18722 0.218954519818226 0.545458349921397 PPARG/RDH10/ADM/HSD17B1/PDSS2/COMT/CLN3/COQ5/PPARD/ACADVL/COQ6/INSIG1/IRS2/AKR1B1 14 GO:0050807 regulation of synapse organization 14/982 211/18722 0.218954519818226 0.545458349921397 DAG1/APP/NRP2/VSTM5/TPBG/SEMA3F/PTN/DLG5/CYFIP1/PPP1R9A/EFNA1/CLN3/SPARC/RAB17 14 GO:0048259 regulation of receptor-mediated endocytosis 8/982 110/18722 0.220005286399013 0.545458349921397 ITGAV/B2M/DAB2/SYNJ1/WASL/AHI1/CD2AP/ANXA2 8 GO:1904659 glucose transmembrane transport 8/982 110/18722 0.220005286399013 0.545458349921397 SORBS1/SLC2A1/PRKCI/YES1/PPARD/IRS2/OPN3/SLC5A3 8 GO:1905954 positive regulation of lipid localization 8/982 110/18722 0.220005286399013 0.545458349921397 LRP1/PPARG/PTGES/HILPDA/C1QTNF1/TRIAP1/RXRA/ANXA2 8 GO:0010828 positive regulation of glucose transmembrane transport 4/982 46/18722 0.220361552845592 0.545458349921397 SORBS1/PRKCI/IRS2/OPN3 4 GO:0031018 endocrine pancreas development 4/982 46/18722 0.220361552845592 0.545458349921397 SOX4/CDK6/BAD/PDPK1 4 GO:0031648 protein destabilization 4/982 46/18722 0.220361552845592 0.545458349921397 SIAH1/HDAC6/MDM2/GSN 4 GO:0033047 regulation of mitotic sister chromatid segregation 4/982 46/18722 0.220361552845592 0.545458349921397 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0034198 cellular response to amino acid starvation 4/982 46/18722 0.220361552845592 0.545458349921397 EIF2AK4/TFEB/SLC38A2/RRAGA 4 GO:0060976 coronary vasculature development 4/982 46/18722 0.220361552845592 0.545458349921397 LRP2/ADAMTS6/NRP1/TGFBR3 4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 4/982 46/18722 0.220361552845592 0.545458349921397 ADAMTS1/EGFR/CCND1/MDM2 4 GO:0002063 chondrocyte development 3/982 31/18722 0.220555695136245 0.545458349921397 SERPINH1/TSKU/AXIN2 3 GO:0006613 cotranslational protein targeting to membrane 3/982 31/18722 0.220555695136245 0.545458349921397 TRAM2/SEC63/SIL1 3 GO:0007190 activation of adenylate cyclase activity 3/982 31/18722 0.220555695136245 0.545458349921397 LGR4/ADRB1/LGR5 3 GO:0031114 regulation of microtubule depolymerization 3/982 31/18722 0.220555695136245 0.545458349921397 HDAC6/CAMSAP2/TPX2 3 GO:0033006 regulation of mast cell activation involved in immune response 3/982 31/18722 0.220555695136245 0.545458349921397 FER/SNX4/PDPK1 3 GO:0035115 embryonic forelimb morphogenesis 3/982 31/18722 0.220555695136245 0.545458349921397 RDH10/TFAP2A/TBX3 3 GO:0042133 neurotransmitter metabolic process 3/982 31/18722 0.220555695136245 0.545458349921397 SLC6A4/COMT/CLN3 3 GO:0048384 retinoic acid receptor signaling pathway 3/982 31/18722 0.220555695136245 0.545458349921397 ESRRG/PPARG/RXRA 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/982 31/18722 0.220555695136245 0.545458349921397 MDM2/TRIAP1/PTTG1IP 3 GO:2000144 positive regulation of DNA-templated transcription, initiation 3/982 31/18722 0.220555695136245 0.545458349921397 MED16/CAND1/MED24 3 GO:0031668 cellular response to extracellular stimulus 16/982 246/18722 0.221633217029096 0.545458349921397 SKP2/CTSV/EIF2AK4/FOLR1/PTN/SLC2A1/WIPI2/ATP2B1/TFEB/COMT/MDM2/TRIM24/GABARAPL1/GSTP1/SLC38A2/RRAGA 16 GO:0035270 endocrine system development 9/982 127/18722 0.222832813463539 0.545458349921397 CDH1/PBX1/ISL1/SOX4/NF1/CDK6/BAD/PDPK1/RBPJ 9 GO:0002690 positive regulation of leukocyte chemotaxis 7/982 94/18722 0.223064373821582 0.545458349921397 SWAP70/PTN/PTK2/CCL5/LGMN/CREB3/PGF 7 GO:0006901 vesicle coating 2/982 17/18722 0.223265639778026 0.545458349921397 TFG/TMED9 2 GO:0007076 mitotic chromosome condensation 2/982 17/18722 0.223265639778026 0.545458349921397 SMC2/KMT5A 2 GO:0007351 tripartite regional subdivision 2/982 17/18722 0.223265639778026 0.545458349921397 BASP1/TBX3 2 GO:0007379 segment specification 2/982 17/18722 0.223265639778026 0.545458349921397 IRX2/COBL 2 GO:0008595 anterior/posterior axis specification, embryo 2/982 17/18722 0.223265639778026 0.545458349921397 BASP1/TBX3 2 GO:0009084 glutamine family amino acid biosynthetic process 2/982 17/18722 0.223265639778026 0.545458349921397 CLN3/ASS1 2 GO:0009200 deoxyribonucleoside triphosphate metabolic process 2/982 17/18722 0.223265639778026 0.545458349921397 DTYMK/ADK 2 GO:0009251 glucan catabolic process 2/982 17/18722 0.223265639778026 0.545458349921397 GAA/AGL 2 GO:0016045 detection of bacterium 2/982 17/18722 0.223265639778026 0.545458349921397 HLA-B/HLA-A 2 GO:0016264 gap junction assembly 2/982 17/18722 0.223265639778026 0.545458349921397 GJA1/GJA5 2 GO:0021924 cell proliferation in external granule layer 2/982 17/18722 0.223265639778026 0.545458349921397 SLC6A4/RERE 2 GO:0021930 cerebellar granule cell precursor proliferation 2/982 17/18722 0.223265639778026 0.545458349921397 SLC6A4/RERE 2 GO:0031445 regulation of heterochromatin assembly 2/982 17/18722 0.223265639778026 0.545458349921397 TRIM28/DNMT1 2 GO:0034349 glial cell apoptotic process 2/982 17/18722 0.223265639778026 0.545458349921397 TNFRSF21/PRKCI 2 GO:0035269 protein O-linked mannosylation 2/982 17/18722 0.223265639778026 0.545458349921397 TMTC3/B4GAT1 2 GO:0035518 histone H2A monoubiquitination 2/982 17/18722 0.223265639778026 0.545458349921397 DDB1/TRIM37 2 GO:0036035 osteoclast development 2/982 17/18722 0.223265639778026 0.545458349921397 FBN1/ANXA2 2 GO:0042953 lipoprotein transport 2/982 17/18722 0.223265639778026 0.545458349921397 LRP1/PPARG 2 GO:0043117 positive regulation of vascular permeability 2/982 17/18722 0.223265639778026 0.545458349921397 TJP1/TJP2 2 GO:0046827 positive regulation of protein export from nucleus 2/982 17/18722 0.223265639778026 0.545458349921397 MDM2/TCF7L2 2 GO:0048339 paraxial mesoderm development 2/982 17/18722 0.223265639778026 0.545458349921397 YAP1/FOXC1 2 GO:0061450 trophoblast cell migration 2/982 17/18722 0.223265639778026 0.545458349921397 ITGB4/GJA1 2 GO:0070293 renal absorption 2/982 17/18722 0.223265639778026 0.545458349921397 CLDN4/GSN 2 GO:0071371 cellular response to gonadotropin stimulus 2/982 17/18722 0.223265639778026 0.545458349921397 GCLM/CCNA2 2 GO:0090399 replicative senescence 2/982 17/18722 0.223265639778026 0.545458349921397 MME/ATR 2 GO:0097067 cellular response to thyroid hormone stimulus 2/982 17/18722 0.223265639778026 0.545458349921397 CTSL/GCLM 2 GO:0120261 regulation of heterochromatin organization 2/982 17/18722 0.223265639778026 0.545458349921397 TRIM28/DNMT1 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/982 17/18722 0.223265639778026 0.545458349921397 YAP1/CD24 2 GO:2000811 negative regulation of anoikis 2/982 17/18722 0.223265639778026 0.545458349921397 PTK2/ITGB1 2 GO:0050900 leukocyte migration 23/982 369/18722 0.224411603990374 0.547538935407494 CD200/APP/CSF3R/SWAP70/MMP14/FER/PTN/JAM3/FLT1/WASL/YES1/PTK2/EPS8/CCL5/MPP1/LGMN/ITGB1/VAV3/DPP4/CREB3/BSG/PGF/F11R 23 GO:0007588 excretion 5/982 62/18722 0.224732146695066 0.547538935407494 ATP6V1B1/ABCG2/NFAT5/COMT/CLN3 5 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 5/982 62/18722 0.224732146695066 0.547538935407494 LRP1/BMP7/PPARG/RBPMS/DAB2 5 GO:0070302 regulation of stress-activated protein kinase signaling cascade 13/982 195/18722 0.224781300319778 0.547538935407494 EGFR/APP/SEMA4C/TRAF4/MARVELD3/IGF1R/HRAS/PAGE4/PHLPP1/PINK1/MAP4K4/PRDX1/GSTP1 13 GO:0008306 associative learning 6/982 78/18722 0.224957043439084 0.547538935407494 APP/TPBG/NF1/CLN3/LGMN/ITGB1 6 GO:0019319 hexose biosynthetic process 6/982 78/18722 0.224957043439084 0.547538935407494 SLC35B4/SLC25A13/DDB1/SLC25A1/RANBP2/AKR1B1 6 GO:0035050 embryonic heart tube development 6/982 78/18722 0.224957043439084 0.547538935407494 YAP1/FOLR1/TBX3/NPHP3/AHI1/FOXC1 6 GO:0061045 negative regulation of wound healing 6/982 78/18722 0.224957043439084 0.547538935407494 GJA1/UBASH3B/CLDN19/C1QTNF1/PDGFA/ANXA2 6 GO:0033865 nucleoside bisphosphate metabolic process 9/982 128/18722 0.229460402435636 0.557719226050455 SLC26A2/ACSS1/GPAM/ACSF2/MVK/SLC25A1/SLC35B2/SUCLA2/HSD17B12 9 GO:0033875 ribonucleoside bisphosphate metabolic process 9/982 128/18722 0.229460402435636 0.557719226050455 SLC26A2/ACSS1/GPAM/ACSF2/MVK/SLC25A1/SLC35B2/SUCLA2/HSD17B12 9 GO:0034032 purine nucleoside bisphosphate metabolic process 9/982 128/18722 0.229460402435636 0.557719226050455 SLC26A2/ACSS1/GPAM/ACSF2/MVK/SLC25A1/SLC35B2/SUCLA2/HSD17B12 9 GO:0001936 regulation of endothelial cell proliferation 12/982 179/18722 0.230786804990306 0.559872421680325 GJA1/NR2F2/NRP2/NRP1/PPARG/NF1/FLT1/SPARC/CYBA/RICTOR/PGF/PDPK1 12 GO:0008585 female gonad development 7/982 95/18722 0.230836666219094 0.559872421680325 ADAMTS1/NR2F2/MMP14/IDH1/NUPR1/BRCA2/FOXC1 7 GO:0050764 regulation of phagocytosis 7/982 95/18722 0.230836666219094 0.559872421680325 ITGAV/LRP1/SYT7/TGM2/CYBA/RAB31/IL2RG 7 GO:0034250 positive regulation of cellular amide metabolic process 11/982 162/18722 0.231021047793805 0.559872421680325 SOX4/EIF2AK4/EFNA1/PLXNB2/YTHDF2/CCL5/PINK1/DHX9/METTL3/UPF3A/VIM 11 GO:0060759 regulation of response to cytokine stimulus 11/982 162/18722 0.231021047793805 0.559872421680325 PPARG/AGPAT1/TRIM6/SPATA2/CD24/YTHDF2/SPPL2B/CCL5/GSTP1/DHX9/METTL3 11 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 4/982 47/18722 0.231698179367007 0.559872421680325 ENPEP/ADRB1/MME/CYBA 4 GO:0010712 regulation of collagen metabolic process 4/982 47/18722 0.231698179367007 0.559872421680325 PPARD/ITGB1/CST3/VIM 4 GO:0010799 regulation of peptidyl-threonine phosphorylation 4/982 47/18722 0.231698179367007 0.559872421680325 APP/BMP7/TRIM6/PARD3 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/982 47/18722 0.231698179367007 0.559872421680325 YAP1/CD24/BASP1/MTSS1 4 GO:0045747 positive regulation of Notch signaling pathway 4/982 47/18722 0.231698179367007 0.559872421680325 YAP1/IL6ST/EPN2/PRKCI 4 GO:0046677 response to antibiotic 4/982 47/18722 0.231698179367007 0.559872421680325 KDM5B/SLC1A3/MDM2/PPP2CB 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/982 47/18722 0.231698179367007 0.559872421680325 LGR4/ACVR2B/ID1/RBPJ 4 GO:0051146 striated muscle cell differentiation 18/982 283/18722 0.231741671473892 0.559872421680325 OBSL1/BHLHE41/ISL1/PARP2/MMP14/ERVW-1/MYOF/CSRP2/TBX3/MORF4L2/LMNA/ITGB1/BIN3/CBY1/FBXO22/KRT8/KLF5/RBPJ 18 GO:0050772 positive regulation of axonogenesis 6/982 79/18722 0.233576228706139 0.56216226310676 PLXNB1/LRP1/NRP1/CYFIP1/PLXNB2/MAP3K13 6 GO:1901184 regulation of ERBB signaling pathway 6/982 79/18722 0.233576228706139 0.56216226310676 EGFR/FER/IFI6/BCAR3/LGMN/RBPJ 6 GO:0006913 nucleocytoplasmic transport 19/982 301/18722 0.233902126877984 0.56216226310676 CDH1/PTPN14/FERMT1/HEATR3/GLI3/TNPO1/TARDBP/MDM2/LMNA/ABCE1/DHX9/NUP153/RANBP2/PTTG1IP/TRIM28/UPF3A/LSG1/TCF7L2/ENY2 19 GO:0051169 nuclear transport 19/982 301/18722 0.233902126877984 0.56216226310676 CDH1/PTPN14/FERMT1/HEATR3/GLI3/TNPO1/TARDBP/MDM2/LMNA/ABCE1/DHX9/NUP153/RANBP2/PTTG1IP/TRIM28/UPF3A/LSG1/TCF7L2/ENY2 19 GO:0002821 positive regulation of adaptive immune response 8/982 112/18722 0.234290425401694 0.56216226310676 TFRC/EIF2AK4/IL6ST/B2M/HLA-B/HLA-A/MAP3K7/HLA-E 8 GO:0009141 nucleoside triphosphate metabolic process 8/982 112/18722 0.234290425401694 0.56216226310676 SLC25A13/TMSB4X/PINK1/NME4/DTYMK/IMPDH2/ADK/NME1 8 GO:0001756 somitogenesis 5/982 63/18722 0.234473143896146 0.56216226310676 COBL/LRP6/AXIN2/FOXC1/RBPJ 5 GO:0031343 positive regulation of cell killing 5/982 63/18722 0.234473143896146 0.56216226310676 CADM1/B2M/HLA-B/HLA-A/HLA-E 5 GO:1904589 regulation of protein import 5/982 63/18722 0.234473143896146 0.56216226310676 CDH1/FERMT1/GLI3/TARDBP/TRIM28 5 GO:0009954 proximal/distal pattern formation 3/982 32/18722 0.234629456821974 0.56216226310676 PBX1/IRX2/GLI3 3 GO:0021799 cerebral cortex radially oriented cell migration 3/982 32/18722 0.234629456821974 0.56216226310676 LAMB1/ADGRG1/GLI3 3 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 3/982 32/18722 0.234629456821974 0.56216226310676 BRD4/ELL/WDR43 3 GO:0035883 enteroendocrine cell differentiation 3/982 32/18722 0.234629456821974 0.56216226310676 CDK6/BAD/PDPK1 3 GO:0042744 hydrogen peroxide catabolic process 3/982 32/18722 0.234629456821974 0.56216226310676 PRDX1/PRDX4/PRDX5 3 GO:0045684 positive regulation of epidermis development 3/982 32/18722 0.234629456821974 0.56216226310676 NCOA3/PPARD/FOXC1 3 GO:0090022 regulation of neutrophil chemotaxis 3/982 32/18722 0.234629456821974 0.56216226310676 JAM3/MPP1/DPP4 3 GO:1901532 regulation of hematopoietic progenitor cell differentiation 3/982 32/18722 0.234629456821974 0.56216226310676 YTHDF2/METTL3/FOXC1 3 GO:1903955 positive regulation of protein targeting to mitochondrion 3/982 32/18722 0.234629456821974 0.56216226310676 PINK1/LEPROT/HUWE1 3 GO:0071248 cellular response to metal ion 13/982 197/18722 0.235477579702662 0.563935287295264 CDH1/EGFR/APP/SYT7/B2M/ALAD/SERPINF1/TFAP2A/HSD17B1/CEBPA/LGMN/ANK3/CLIC4 13 GO:0002718 regulation of cytokine production involved in immune response 7/982 96/18722 0.238698678782157 0.569041463192473 B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 7 GO:0006637 acyl-CoA metabolic process 7/982 96/18722 0.238698678782157 0.569041463192473 ACSS1/GPAM/ACSF2/MVK/SLC25A1/SUCLA2/HSD17B12 7 GO:0035383 thioester metabolic process 7/982 96/18722 0.238698678782157 0.569041463192473 ACSS1/GPAM/ACSF2/MVK/SLC25A1/SUCLA2/HSD17B12 7 GO:0042158 lipoprotein biosynthetic process 7/982 96/18722 0.238698678782157 0.569041463192473 PGAP2/PGAP1/WIPI2/PIGU/PIGF/ZDHHC3/GPAA1 7 GO:1901655 cellular response to ketone 7/982 96/18722 0.238698678782157 0.569041463192473 EGFR/GNAI1/SERPINF1/ATP2B1/P2RY6/AKR1B1/ASS1 7 GO:0031669 cellular response to nutrient levels 14/982 215/18722 0.239399421351979 0.569041463192473 CTSV/EIF2AK4/FOLR1/PTN/SLC2A1/WIPI2/ATP2B1/TFEB/COMT/MDM2/TRIM24/GABARAPL1/SLC38A2/RRAGA 14 GO:0044106 cellular amine metabolic process 8/982 113/18722 0.241551521778029 0.569041463192473 EPAS1/COMT/ALDH7A1/CLN3/SLC44A1/SMS/AKR1B1/AZIN1 8 GO:0045766 positive regulation of angiogenesis 12/982 181/18722 0.24212104723986 0.569041463192473 ISL1/NRP1/ITGB8/GAB1/ADM/FLT1/TJP1/ITGB1/GRN/PGF/PDPK1/ANXA3 12 GO:0097696 receptor signaling pathway via STAT 12/982 181/18722 0.24212104723986 0.569041463192473 PRLR/SOCS6/ISL1/PPARG/IL6ST/FER/PIGU/IL10RB/CCL5/STAMBP/AKR1B1/LEPROT 12 GO:1904018 positive regulation of vasculature development 12/982 181/18722 0.24212104723986 0.569041463192473 ISL1/NRP1/ITGB8/GAB1/ADM/FLT1/TJP1/ITGB1/GRN/PGF/PDPK1/ANXA3 12 GO:0021766 hippocampus development 6/982 80/18722 0.242296070326957 0.569041463192473 TSKU/GLI3/CDK6/UBA6/NME1/ANXA3 6 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 9/982 130/18722 0.242928558030881 0.569041463192473 PGAP1/LMAN1/TMED4/TFG/COPB2/INSIG1/CREB3L2/TRIP11/TMED9 9 GO:0043467 regulation of generation of precursor metabolites and energy 9/982 130/18722 0.242928558030881 0.569041463192473 APP/SORBS1/PHLDA2/IL10RB/PPP1R3E/PINK1/NUPR1/IRS2/OPN3 9 GO:2001242 regulation of intrinsic apoptotic signaling pathway 11/982 164/18722 0.242966307824504 0.569041463192473 SIAH1/WFS1/P4HB/MDM2/TRIAP1/PINK1/NUPR1/USP47/PTTG1IP/CREB3/BAD 11 GO:0002643 regulation of tolerance induction 2/982 18/18722 0.243024349960965 0.569041463192473 HLA-B/PHLPP1 2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process 2/982 18/18722 0.243024349960965 0.569041463192473 ALG6/DPAGT1 2 GO:0006595 polyamine metabolic process 2/982 18/18722 0.243024349960965 0.569041463192473 SMS/AZIN1 2 GO:0007250 activation of NF-kappaB-inducing kinase activity 2/982 18/18722 0.243024349960965 0.569041463192473 TRAF4/MAP3K7 2 GO:0008272 sulfate transport 2/982 18/18722 0.243024349960965 0.569041463192473 SLC26A2/RACGAP1 2 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 2/982 18/18722 0.243024349960965 0.569041463192473 NME4/NME1 2 GO:0019184 nonribosomal peptide biosynthetic process 2/982 18/18722 0.243024349960965 0.569041463192473 GSS/GCLM 2 GO:0019896 axonal transport of mitochondrion 2/982 18/18722 0.243024349960965 0.569041463192473 HDAC6/ARMCX3 2 GO:0021534 cell proliferation in hindbrain 2/982 18/18722 0.243024349960965 0.569041463192473 SLC6A4/RERE 2 GO:0030206 chondroitin sulfate biosynthetic process 2/982 18/18722 0.243024349960965 0.569041463192473 CHPF/XYLT1 2 GO:0030299 intestinal cholesterol absorption 2/982 18/18722 0.243024349960965 0.569041463192473 LDLR/LIMA1 2 GO:0030730 sequestering of triglyceride 2/982 18/18722 0.243024349960965 0.569041463192473 PPARG/PNPLA2 2 GO:0030889 negative regulation of B cell proliferation 2/982 18/18722 0.243024349960965 0.569041463192473 PAWR/TNFRSF21 2 GO:0031643 positive regulation of myelination 2/982 18/18722 0.243024349960965 0.569041463192473 DAG1/PARD3 2 GO:0031649 heat generation 2/982 18/18722 0.243024349960965 0.569041463192473 ADRB1/PTGES 2 GO:0042693 muscle cell fate commitment 2/982 18/18722 0.243024349960965 0.569041463192473 TBX3/RBPJ 2 GO:0043116 negative regulation of vascular permeability 2/982 18/18722 0.243024349960965 0.569041463192473 ADM/FERMT2 2 GO:0043217 myelin maintenance 2/982 18/18722 0.243024349960965 0.569041463192473 DEGS1/EPB41L3 2 GO:0044247 cellular polysaccharide catabolic process 2/982 18/18722 0.243024349960965 0.569041463192473 GAA/AGL 2 GO:0048268 clathrin coat assembly 2/982 18/18722 0.243024349960965 0.569041463192473 NSG1/CLTC 2 GO:0051382 kinetochore assembly 2/982 18/18722 0.243024349960965 0.569041463192473 CENPF/CENPW 2 GO:0051895 negative regulation of focal adhesion assembly 2/982 18/18722 0.243024349960965 0.569041463192473 LRP1/MMP14 2 GO:0060008 Sertoli cell differentiation 2/982 18/18722 0.243024349960965 0.569041463192473 CTSV/RAB13 2 GO:0060973 cell migration involved in heart development 2/982 18/18722 0.243024349960965 0.569041463192473 BMP7/FOLR1 2 GO:0071786 endoplasmic reticulum tubular network organization 2/982 18/18722 0.243024349960965 0.569041463192473 REEP1/TMEM33 2 GO:0072234 metanephric nephron tubule development 2/982 18/18722 0.243024349960965 0.569041463192473 LGR4/YAP1 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/982 18/18722 0.243024349960965 0.569041463192473 LGR4/MAGED1 2 GO:0150118 negative regulation of cell-substrate junction organization 2/982 18/18722 0.243024349960965 0.569041463192473 LRP1/MMP14 2 GO:1900424 regulation of defense response to bacterium 2/982 18/18722 0.243024349960965 0.569041463192473 CYBA/GRN 2 GO:1902001 fatty acid transmembrane transport 2/982 18/18722 0.243024349960965 0.569041463192473 SLC2A1/IRS2 2 GO:1903209 positive regulation of oxidative stress-induced cell death 2/982 18/18722 0.243024349960965 0.569041463192473 PAWR/HDAC6 2 GO:0002673 regulation of acute inflammatory response 4/982 48/18722 0.243173585401845 0.569041463192473 IL6ST/PTGES/HLA-E/GSTP1 4 GO:0002715 regulation of natural killer cell mediated immunity 4/982 48/18722 0.243173585401845 0.569041463192473 CADM1/HLA-B/HLA-A/HLA-E 4 GO:0010569 regulation of double-strand break repair via homologous recombination 4/982 48/18722 0.243173585401845 0.569041463192473 POLQ/RMI2/MAGEF1/WDR48 4 GO:0015804 neutral amino acid transport 4/982 48/18722 0.243173585401845 0.569041463192473 SLC38A9/SLC43A2/SLC1A5/SLC38A2 4 GO:0090199 regulation of release of cytochrome c from mitochondria 4/982 48/18722 0.243173585401845 0.569041463192473 TRIAP1/PINK1/LMNA/BAD 4 GO:1903053 regulation of extracellular matrix organization 4/982 48/18722 0.243173585401845 0.569041463192473 DAG1/LRP1/CST3/DPP4 4 GO:0016570 histone modification 28/982 463/18722 0.243559529652407 0.569689016442581 KDM5B/ISL1/UTY/PARP2/DDB1/BRD4/MTA3/RCOR1/BRCC3/MAP3K7/TET2/NCOA3/TBL1X/HDAC6/MORF4L2/PINK1/LMNA/ZNF451/TRIM37/BRCA2/SIN3B/RPS6KA4/MED24/DNMT1/KMT5A/ENY2/CCNA2/HUWE1 28 GO:0001885 endothelial cell development 5/982 64/18722 0.244329921956716 0.570212471107933 MET/TJP1/TJP2/CLIC4/F11R 5 GO:0016126 sterol biosynthetic process 5/982 64/18722 0.244329921956716 0.570212471107933 SQLE/CYB5R1/DHCR24/MVK/INSIG1 5 GO:0030858 positive regulation of epithelial cell differentiation 5/982 64/18722 0.244329921956716 0.570212471107933 CD24/NCOA3/AHI1/FOXC1/BAD 5 GO:0050771 negative regulation of axonogenesis 5/982 64/18722 0.244329921956716 0.570212471107933 SEMA6D/SEMA6A/NRP1/SEMA3F/SEMA4C 5 GO:1903018 regulation of glycoprotein metabolic process 5/982 64/18722 0.244329921956716 0.570212471107933 PAWR/CST3/TCF7L2/BACE2/ITM2C 5 GO:0035335 peptidyl-tyrosine dephosphorylation 7/982 97/18722 0.246645842746544 0.574845717500435 PTPN14/UBASH3B/PTPRK/PTPRF/DUSP6/DUSP5/DUSP14 7 GO:0070252 actin-mediated cell contraction 7/982 97/18722 0.246645842746544 0.574845717500435 GJA1/GJA5/DSG2/DSP/DSC2/PKP2/GSN 7 GO:0120162 positive regulation of cold-induced thermogenesis 7/982 97/18722 0.246645842746544 0.574845717500435 GJA1/ESRRG/PRLR/ADRB1/EPAS1/IGF1R/FH 7 GO:0018108 peptidyl-tyrosine phosphorylation 23/982 375/18722 0.247847453692772 0.576719006714829 EGFR/MET/PRLR/APP/FGFR2/ISL1/EFEMP1/NRP1/WEE1/IL6ST/FER/EFNA5/ERBB3/IGF1R/FLT1/EFNA1/EPHB4/YES1/PTK2/CD24/CCL5/PDGFA/RICTOR 23 GO:0051260 protein homooligomerization 12/982 182/18722 0.247865861087243 0.576719006714829 KCTD1/VSTM5/KCNG1/POLQ/B2M/ALAD/TK1/ALS2/SLC1A5/CBY1/EHD3/BCL10 12 GO:0002431 Fc receptor mediated stimulatory signaling pathway 3/982 33/18722 0.248855125776691 0.576719006714829 YES1/PTK2/VAV3 3 GO:0006891 intra-Golgi vesicle-mediated transport 3/982 33/18722 0.248855125776691 0.576719006714829 CUX1/COPB2/NAPA 3 GO:0035025 positive regulation of Rho protein signal transduction 3/982 33/18722 0.248855125776691 0.576719006714829 NET1/ADGRG1/F11R 3 GO:0042558 pteridine-containing compound metabolic process 3/982 33/18722 0.248855125776691 0.576719006714829 SLC19A1/FOLR1/ATIC 3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 3/982 33/18722 0.248855125776691 0.576719006714829 FLT1/PTK2/VAV3 3 GO:0046320 regulation of fatty acid oxidation 3/982 33/18722 0.248855125776691 0.576719006714829 PPARD/ACADVL/IRS2 3 GO:0046685 response to arsenic-containing substance 3/982 33/18722 0.248855125776691 0.576719006714829 ALAD/SERPINF1/SLC38A2 3 GO:0150117 positive regulation of cell-substrate junction organization 3/982 33/18722 0.248855125776691 0.576719006714829 NRP1/FERMT2/MAP4K4 3 GO:0008645 hexose transmembrane transport 8/982 114/18722 0.248886979316542 0.576719006714829 SORBS1/SLC2A1/PRKCI/YES1/PPARD/IRS2/OPN3/SLC5A3 8 GO:0019751 polyol metabolic process 8/982 114/18722 0.248886979316542 0.576719006714829 PLPP3/ISYNA1/SYNJ1/NUDT4/P2RY6/AKR1B1/SLC5A3/SPTLC3 8 GO:1903008 organelle disassembly 8/982 114/18722 0.248886979316542 0.576719006714829 WIPI2/CTTN/SLC25A4/HDAC6/PINK1/UBA5/GABARAPL1/HUWE1 8 GO:0046683 response to organophosphorus 9/982 131/18722 0.249763604256323 0.578493321403633 SLC6A4/APP/P2RY6/SPARC/BSG/HSP90B1/CDO1/NME1/ASS1 9 GO:0061448 connective tissue development 16/982 252/18722 0.250363233699499 0.579624778950994 LRP5/BMP7/SCIN/SERPINH1/EFEMP1/NFIB/ITGB8/TSKU/GLI3/AXIN2/ESRRA/PPARD/CREB3L2/GLG1/SMAD5/TRIP11 16 GO:2000106 regulation of leukocyte apoptotic process 6/982 81/18722 0.251110273213535 0.581096355404526 GPAM/EFNA1/SLC39A10/CCL5/IRS2/BCL10 6 GO:0044282 small molecule catabolic process 23/982 376/18722 0.251850788957582 0.582551536675276 GLDC/LRP5/SLC27A2/FUT8/ACADS/SYNJ1/ECI1/GSTZ1/QPRT/PPARD/ACADVL/SLC25A17/DECR2/PPAT/ECHDC2/IRS2/TST/RPE/GCSH/CDO1/ENOSF1/BAD/HADHB 23 GO:0003170 heart valve development 5/982 65/18722 0.25429327310626 0.583360735118626 GJA5/SOX4/EFNA1/MDM2/RBPJ 5 GO:0015909 long-chain fatty acid transport 5/982 65/18722 0.25429327310626 0.583360735118626 SLC27A2/PPARG/SLC2A1/PLA2G12A/IRS2 5 GO:0045682 regulation of epidermis development 5/982 65/18722 0.25429327310626 0.583360735118626 ESRP1/MAFG/NCOA3/PPARD/FOXC1 5 GO:0070613 regulation of protein processing 5/982 65/18722 0.25429327310626 0.583360735118626 MMP14/CLN3/MDM2/GSN/GLG1 5 GO:0002367 cytokine production involved in immune response 7/982 98/18722 0.25467353922282 0.583360735118626 B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 7 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 7/982 98/18722 0.25467353922282 0.583360735118626 WFS1/MDM2/TRIAP1/PINK1/USP47/PTTG1IP/CREB3 7 GO:0001913 T cell mediated cytotoxicity 4/982 49/18722 0.254772959087467 0.583360735118626 B2M/HLA-B/HLA-A/HLA-E 4 GO:0002762 negative regulation of myeloid leukocyte differentiation 4/982 49/18722 0.254772959087467 0.583360735118626 FBN1/UBASH3B/CDK6/NME1 4 GO:0006692 prostanoid metabolic process 4/982 49/18722 0.254772959087467 0.583360735118626 ATP6V1B1/PTGES/GSTP1/AKR1B1 4 GO:0006693 prostaglandin metabolic process 4/982 49/18722 0.254772959087467 0.583360735118626 ATP6V1B1/PTGES/GSTP1/AKR1B1 4 GO:0008038 neuron recognition 4/982 49/18722 0.254772959087467 0.583360735118626 APP/NRP1/TNFRSF21/BSG 4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 4/982 49/18722 0.254772959087467 0.583360735118626 BMP7/PPARG/RBPMS/DAB2 4 GO:0014075 response to amine 4/982 49/18722 0.254772959087467 0.583360735118626 GLDC/RANBP2/NME1/ASS1 4 GO:0021515 cell differentiation in spinal cord 4/982 49/18722 0.254772959087467 0.583360735118626 ISL1/SOX4/GLI3/LMO4 4 GO:0030195 negative regulation of blood coagulation 4/982 49/18722 0.254772959087467 0.583360735118626 UBASH3B/C1QTNF1/PDGFA/ANXA2 4 GO:0030857 negative regulation of epithelial cell differentiation 4/982 49/18722 0.254772959087467 0.583360735118626 YAP1/ID1/CCND1/TBX3 4 GO:0043330 response to exogenous dsRNA 4/982 49/18722 0.254772959087467 0.583360735118626 COLEC12/ZCCHC3/DHX9/DDX1 4 GO:0043457 regulation of cellular respiration 4/982 49/18722 0.254772959087467 0.583360735118626 IL10RB/PINK1/NUPR1/OPN3 4 GO:0051932 synaptic transmission, GABAergic 4/982 49/18722 0.254772959087467 0.583360735118626 TPBG/GABRE/CLN3/ZDHHC3 4 GO:0060986 endocrine hormone secretion 4/982 49/18722 0.254772959087467 0.583360735118626 GJA1/TRPV6/C1QTNF1/TBX3 4 GO:1904752 regulation of vascular associated smooth muscle cell migration 4/982 49/18722 0.254772959087467 0.583360735118626 ADAMTS1/LRP1/GNA12/MDM2 4 GO:1904894 positive regulation of receptor signaling pathway via STAT 4/982 49/18722 0.254772959087467 0.583360735118626 PRLR/IL10RB/CCL5/AKR1B1 4 GO:1990928 response to amino acid starvation 4/982 49/18722 0.254772959087467 0.583360735118626 EIF2AK4/TFEB/SLC38A2/RRAGA 4 GO:0042445 hormone metabolic process 14/982 218/18722 0.255209569484086 0.58359189584787 ENPEP/MME/RDH10/ADM/CTSL/HSD17B1/RDH14/COMT/PNPLA2/CPQ/AKR1B1/HSD17B12/TCF7L2/BACE2 14 GO:0045088 regulation of innate immune response 14/982 218/18722 0.255209569484086 0.58359189584787 CADM1/PPARG/HLA-B/HLA-A/TRIM6/MAP3K7/HLA-E/YTHDF2/ZCCHC3/CCL5/PSPC1/DHX9/GRN/METTL3 14 GO:0050803 regulation of synapse structure or activity 14/982 218/18722 0.255209569484086 0.58359189584787 DAG1/APP/NRP2/VSTM5/TPBG/SEMA3F/PTN/DLG5/CYFIP1/PPP1R9A/EFNA1/CLN3/SPARC/RAB17 14 GO:0032368 regulation of lipid transport 10/982 149/18722 0.256189722513638 0.585200889985834 ITGAV/LRP1/KDM5B/PPARG/PTGES/C1QTNF1/TRIAP1/RXRA/IRS2/ANXA2 10 GO:0051592 response to calcium ion 10/982 149/18722 0.256189722513638 0.585200889985834 EGFR/SYT7/SLC25A13/TRPV6/PTGES/CCND1/SPARC/LGMN/CLIC4/BAD 10 GO:1901989 positive regulation of cell cycle phase transition 8/982 115/18722 0.256293247266158 0.585200889985834 ADAMTS1/PBX1/EGFR/APP/BRD4/MTA3/CCND1/MDM2 8 GO:0007051 spindle organization 12/982 184/18722 0.259502797250502 0.585200889985834 TACC2/ASPM/GNAI1/LIMK2/EML1/RACGAP1/CLTC/PLK2/TPX2/DCTN6/KIF4A/SAC3D1 12 GO:0018212 peptidyl-tyrosine modification 23/982 378/18722 0.259936524489119 0.585200889985834 EGFR/MET/PRLR/APP/FGFR2/ISL1/EFEMP1/NRP1/WEE1/IL6ST/FER/EFNA5/ERBB3/IGF1R/FLT1/EFNA1/EPHB4/YES1/PTK2/CD24/CCL5/PDGFA/RICTOR 23 GO:0007032 endosome organization 6/982 82/18722 0.260012505145203 0.585200889985834 HOOK2/HOOK1/ALS2/SYNJ1/HOOK3/SCARB2 6 GO:0009205 purine ribonucleoside triphosphate metabolic process 6/982 82/18722 0.260012505145203 0.585200889985834 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/NME1 6 GO:0046364 monosaccharide biosynthetic process 6/982 82/18722 0.260012505145203 0.585200889985834 SLC35B4/SLC25A13/DDB1/SLC25A1/RANBP2/AKR1B1 6 GO:1905897 regulation of response to endoplasmic reticulum stress 6/982 82/18722 0.260012505145203 0.585200889985834 WFS1/TMEM33/NUPR1/CREB3/USP14/USP25 6 GO:2001252 positive regulation of chromosome organization 6/982 82/18722 0.260012505145203 0.585200889985834 FEN1/PKIB/ATR/TRIM28/DNMT1/RAD50 6 GO:0055088 lipid homeostasis 11/982 167/18722 0.261294100551653 0.585200889985834 LRP5/PPARG/GPAM/TSKU/LDLR/CD24/CEBPA/PNPLA2/LIMA1/INSIG1/IRS2 11 GO:0001959 regulation of cytokine-mediated signaling pathway 10/982 150/18722 0.262718617002734 0.585200889985834 PPARG/AGPAT1/TRIM6/SPATA2/CD24/YTHDF2/SPPL2B/CCL5/GSTP1/METTL3 10 GO:0021510 spinal cord development 7/982 99/18722 0.26277710818057 0.585200889985834 VSTM5/ISL1/SOX4/PTN/NF1/GLI3/LMO4 7 GO:0021549 cerebellum development 7/982 99/18722 0.26277710818057 0.585200889985834 NAGLU/SEMA4C/PTN/PDSS2/RERE/FOXC1/ATIC 7 GO:0060996 dendritic spine development 7/982 99/18722 0.26277710818057 0.585200889985834 DLG5/PPP1R9A/EFNA1/WASL/HDAC6/UBA6/PLK2 7 GO:0002523 leukocyte migration involved in inflammatory response 2/982 19/18722 0.262849177701755 0.585200889985834 PTN/JAM3 2 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 2/982 19/18722 0.262849177701755 0.585200889985834 HLA-E/DDX1 2 GO:0006007 glucose catabolic process 2/982 19/18722 0.262849177701755 0.585200889985834 LRP5/BAD 2 GO:0006044 N-acetylglucosamine metabolic process 2/982 19/18722 0.262849177701755 0.585200889985834 EXTL2/MGAT3 2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 2/982 19/18722 0.262849177701755 0.585200889985834 ALG6/DPAGT1 2 GO:0006670 sphingosine metabolic process 2/982 19/18722 0.262849177701755 0.585200889985834 PLPP3/SPTLC3 2 GO:0009226 nucleotide-sugar biosynthetic process 2/982 19/18722 0.262849177701755 0.585200889985834 GFPT1/PMM2 2 GO:0010002 cardioblast differentiation 2/982 19/18722 0.262849177701755 0.585200889985834 ISL1/RBPJ 2 GO:0010759 positive regulation of macrophage chemotaxis 2/982 19/18722 0.262849177701755 0.585200889985834 PTK2/CCL5 2 GO:0010885 regulation of cholesterol storage 2/982 19/18722 0.262849177701755 0.585200889985834 PPARG/PPARD 2 GO:0016082 synaptic vesicle priming 2/982 19/18722 0.262849177701755 0.585200889985834 SYNJ1/NAPA 2 GO:0031290 retinal ganglion cell axon guidance 2/982 19/18722 0.262849177701755 0.585200889985834 ISL1/NRP1 2 GO:0032011 ARF protein signal transduction 2/982 19/18722 0.262849177701755 0.585200889985834 MAP4K4/CYTH3 2 GO:0032012 regulation of ARF protein signal transduction 2/982 19/18722 0.262849177701755 0.585200889985834 MAP4K4/CYTH3 2 GO:0032616 interleukin-13 production 2/982 19/18722 0.262849177701755 0.585200889985834 TNFRSF21/HLA-E 2 GO:0032656 regulation of interleukin-13 production 2/982 19/18722 0.262849177701755 0.585200889985834 TNFRSF21/HLA-E 2 GO:0035313 wound healing, spreading of epidermal cells 2/982 19/18722 0.262849177701755 0.585200889985834 FERMT1/FERMT2 2 GO:0042474 middle ear morphogenesis 2/982 19/18722 0.262849177701755 0.585200889985834 NAGLU/INSIG1 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/982 19/18722 0.262849177701755 0.585200889985834 TOP2A/TRIM28 2 GO:0045618 positive regulation of keratinocyte differentiation 2/982 19/18722 0.262849177701755 0.585200889985834 NCOA3/FOXC1 2 GO:0045780 positive regulation of bone resorption 2/982 19/18722 0.262849177701755 0.585200889985834 EGFR/TFRC 2 GO:0046033 AMP metabolic process 2/982 19/18722 0.262849177701755 0.585200889985834 ADSL/ADK 2 GO:0046782 regulation of viral transcription 2/982 19/18722 0.262849177701755 0.585200889985834 DHX9/TRIM27 2 GO:0046794 transport of virus 2/982 19/18722 0.262849177701755 0.585200889985834 CTSL/NUP153 2 GO:0060216 definitive hemopoiesis 2/982 19/18722 0.262849177701755 0.585200889985834 TGFBR3/MFAP5 2 GO:0062099 negative regulation of programmed necrotic cell death 2/982 19/18722 0.262849177701755 0.585200889985834 SLC25A4/NUPR1 2 GO:0070262 peptidyl-serine dephosphorylation 2/982 19/18722 0.262849177701755 0.585200889985834 SWAP70/PPP2CB 2 GO:0072074 kidney mesenchyme development 2/982 19/18722 0.262849177701755 0.585200889985834 BMP7/BASP1 2 GO:0086014 atrial cardiac muscle cell action potential 2/982 19/18722 0.262849177701755 0.585200889985834 GJA1/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/982 19/18722 0.262849177701755 0.585200889985834 GJA1/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/982 19/18722 0.262849177701755 0.585200889985834 GJA1/GJA5 2 GO:1901659 glycosyl compound biosynthetic process 2/982 19/18722 0.262849177701755 0.585200889985834 DTYMK/ADK 2 GO:1903978 regulation of microglial cell activation 2/982 19/18722 0.262849177701755 0.585200889985834 LDLR/GRN 2 GO:2000251 positive regulation of actin cytoskeleton reorganization 2/982 19/18722 0.262849177701755 0.585200889985834 NRP1/HRAS 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/982 19/18722 0.262849177701755 0.585200889985834 DAB2/WASL 2 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 2/982 19/18722 0.262849177701755 0.585200889985834 HLA-A/HLA-E 2 GO:0000819 sister chromatid segregation 13/982 202/18722 0.263055853237048 0.585200889985834 CENPF/SMC2/CHTF8/AXIN2/ZWINT/SPDL1/RACGAP1/FEN1/RMI2/TOP2A/KMT5A/KIF4A/LCMT1 13 GO:0001662 behavioral fear response 3/982 34/18722 0.263205308836255 0.585200889985834 GJA1/ALS2/DPP4 3 GO:0007095 mitotic G2 DNA damage checkpoint signaling 3/982 34/18722 0.263205308836255 0.585200889985834 BRCC3/FOXO4/TOPBP1 3 GO:0009649 entrainment of circadian clock 3/982 34/18722 0.263205308836255 0.585200889985834 GNA11/PHLPP1/NR2F6 3 GO:0016242 negative regulation of macroautophagy 3/982 34/18722 0.263205308836255 0.585200889985834 PINK1/NUPR1/PHF23 3 GO:0019320 hexose catabolic process 3/982 34/18722 0.263205308836255 0.585200889985834 LRP5/FUT8/BAD 3 GO:0043276 anoikis 3/982 34/18722 0.263205308836255 0.585200889985834 PTK2/MAP3K7/ITGB1 3 GO:0048854 brain morphogenesis 3/982 34/18722 0.263205308836255 0.585200889985834 SLC6A4/NF1/FZD6 3 GO:0055094 response to lipoprotein particle 3/982 34/18722 0.263205308836255 0.585200889985834 PPARG/LDLR/ITGB1 3 GO:0070232 regulation of T cell apoptotic process 3/982 34/18722 0.263205308836255 0.585200889985834 GPAM/EFNA1/CCL5 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/982 34/18722 0.263205308836255 0.585200889985834 GJA1/GJA5/PKP2 3 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/982 34/18722 0.263205308836255 0.585200889985834 ISL1/SOX4/RPS6KA4 3 GO:2000780 negative regulation of double-strand break repair 3/982 34/18722 0.263205308836255 0.585200889985834 POLQ/RMI2/MAGEF1 3 GO:0010565 regulation of cellular ketone metabolic process 9/982 133/18722 0.263621524665384 0.585200889985834 PPARG/RDH10/ADM/COMT/CLN3/PPARD/ACADVL/INSIG1/IRS2 9 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 9/982 133/18722 0.263621524665384 0.585200889985834 TMTC3/DAB2/PTK2/CEBPA/MDM2/MAGEF1/NUPR1/PLK2/FBXO22 9 GO:0008286 insulin receptor signaling pathway 8/982 116/18722 0.263766735497833 0.585200889985834 KANK1/SORBS1/FER/GAB1/IGF1R/FOXO4/BCAR3/IRS2 8 GO:0015749 monosaccharide transmembrane transport 8/982 116/18722 0.263766735497833 0.585200889985834 SORBS1/SLC2A1/PRKCI/YES1/PPARD/IRS2/OPN3/SLC5A3 8 GO:0033559 unsaturated fatty acid metabolic process 8/982 116/18722 0.263766735497833 0.585200889985834 ATP6V1B1/ABHD12/DEGS1/PTGES/CYP2J2/GSTP1/DECR2/AKR1B1 8 GO:0035967 cellular response to topologically incorrect protein 8/982 116/18722 0.263766735497833 0.585200889985834 UGGT2/WFS1/CCND1/HDAC6/TMEM33/TM7SF3/CREB3L2/CREB3 8 GO:0019229 regulation of vasoconstriction 5/982 66/18722 0.26435400110714 0.585756359292625 GJA1/EGFR/GJA5/ADM/ATP2B1 5 GO:0050918 positive chemotaxis 5/982 66/18722 0.26435400110714 0.585756359292625 MET/LRP1/NRP1/CCL5/PGF 5 GO:1905953 negative regulation of lipid localization 5/982 66/18722 0.26435400110714 0.585756359292625 ITGAV/PPARG/PPARD/PNPLA2/IRS2 5 GO:0042572 retinol metabolic process 4/982 50/18722 0.266481674706842 0.588969667487665 RDH10/RDH14/PNPLA2/AKR1B1 4 GO:0050873 brown fat cell differentiation 4/982 50/18722 0.266481674706842 0.588969667487665 ADRB1/BMP7/ARL4A/CEBPA 4 GO:0071709 membrane assembly 4/982 50/18722 0.266481674706842 0.588969667487665 PACSIN2/ANK3/FLOT2/ANXA2 4 GO:1900047 negative regulation of hemostasis 4/982 50/18722 0.266481674706842 0.588969667487665 UBASH3B/C1QTNF1/PDGFA/ANXA2 4 GO:1903747 regulation of establishment of protein localization to mitochondrion 4/982 50/18722 0.266481674706842 0.588969667487665 LMAN1/PINK1/LEPROT/HUWE1 4 GO:1904738 vascular associated smooth muscle cell migration 4/982 50/18722 0.266481674706842 0.588969667487665 ADAMTS1/LRP1/GNA12/MDM2 4 GO:1902806 regulation of cell cycle G1/S phase transition 11/982 168/18722 0.267504935194185 0.59098083099232 ADAMTS1/EGFR/SOX4/WEE1/CTDSPL/CCND1/MDM2/TRIAP1/PLK2/PSME3/GTSE1 11 GO:0051259 protein complex oligomerization 15/982 238/18722 0.268334819627484 0.592563259600743 KCTD1/VSTM5/HGSNAT/KCNG1/POLQ/B2M/ALAD/TK1/ALS2/SLC1A5/CBY1/EHD3/LRRC8D/BCL10/RRM1 15 GO:0006261 DNA-dependent DNA replication 10/982 151/18722 0.269300736906874 0.594444622812634 POLQ/MCM2/CHTF8/WRNIP1/FEN1/WDHD1/ATR/TOPBP1/BRCA2/CCNE1 10 GO:0070372 regulation of ERK1 and ERK2 cascade 19/982 309/18722 0.269583361906939 0.59481675791311 SEMA6A/EGFR/LRP1/APP/FGFR2/TPBG/NRP1/WNK2/GCNT2/FBLN1/DUSP9/HRAS/TIMP3/FERMT2/P2RY6/CCL5/PDGFA/DUSP6/GSTP1 19 GO:1903522 regulation of blood circulation 16/982 256/18722 0.270279347539963 0.596100243876722 GJA1/EGFR/ADRB1/GJA5/DSG2/DSP/ISL1/DSC2/GAA/EPAS1/ADM/ATP2B1/CYP2J2/MDM2/PKP2/EHD3 16 GO:0002831 regulation of response to biotic stimulus 20/982 327/18722 0.270519467242005 0.596377658974767 CADM1/EIF2AK4/PPARG/HLA-B/HLA-A/ELMOD2/TRIM6/MAP3K7/PUM1/HLA-E/YTHDF2/ZCCHC3/CCL5/CYBA/PSPC1/TSPAN6/PUM2/DHX9/GRN/METTL3 20 GO:0046545 development of primary female sexual characteristics 7/982 100/18722 0.270951857240249 0.596826388245413 ADAMTS1/NR2F2/MMP14/IDH1/NUPR1/BRCA2/FOXC1 7 GO:0061640 cytoskeleton-dependent cytokinesis 7/982 100/18722 0.270951857240249 0.596826388245413 MYH10/RASA1/RACGAP1/BIN3/ANK3/STAMBP/KIF4A 7 GO:0002702 positive regulation of production of molecular mediator of immune response 8/982 117/18722 0.271303820389114 0.597349399387767 TFRC/B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 8 GO:0008643 carbohydrate transport 10/982 152/18722 0.275933692559043 0.606974589175572 SLC35B4/SORBS1/SLC2A1/PRKCI/YES1/PPARD/SLC35D1/IRS2/OPN3/SLC5A3 10 GO:0019221 cytokine-mediated signaling pathway 28/982 472/18722 0.276455355771326 0.606974589175572 LIFR/PRLR/CSF3R/CSF2RA/YAP1/PPARG/IL6ST/FER/TMSB4X/AGPAT1/TRIM6/SPATA2/IL10RB/MAP3K7/CD24/CEBPA/KRT18/P4HB/YTHDF2/SPPL2B/CCL5/GSTP1/METTL3/RPS6KA4/FOXC1/IL2RG/KRT8/BAD 28 GO:0002209 behavioral defense response 3/982 35/18722 0.277653636842967 0.606974589175572 GJA1/ALS2/DPP4 3 GO:0006739 NADP metabolic process 3/982 35/18722 0.277653636842967 0.606974589175572 RPIA/IDH1/RPE 3 GO:0010664 negative regulation of striated muscle cell apoptotic process 3/982 35/18722 0.277653636842967 0.606974589175572 BMP7/NUPR1/PDPK1 3 GO:0010837 regulation of keratinocyte proliferation 3/982 35/18722 0.277653636842967 0.606974589175572 FGFR2/YAP1/PTPRK 3 GO:0031076 embryonic camera-type eye development 3/982 35/18722 0.277653636842967 0.606974589175572 BMP7/RDH10/TFAP2A 3 GO:0032350 regulation of hormone metabolic process 3/982 35/18722 0.277653636842967 0.606974589175572 RDH10/ADM/TCF7L2 3 GO:0034405 response to fluid shear stress 3/982 35/18722 0.277653636842967 0.606974589175572 GJA1/MTSS1/ASS1 3 GO:0040001 establishment of mitotic spindle localization 3/982 35/18722 0.277653636842967 0.606974589175572 GJA1/SPDL1/ITGB1 3 GO:0044273 sulfur compound catabolic process 3/982 35/18722 0.277653636842967 0.606974589175572 GNS/TST/CDO1 3 GO:0045907 positive regulation of vasoconstriction 3/982 35/18722 0.277653636842967 0.606974589175572 GJA1/EGFR/GJA5 3 GO:0050654 chondroitin sulfate proteoglycan metabolic process 3/982 35/18722 0.277653636842967 0.606974589175572 CHPF/DSEL/XYLT1 3 GO:0060236 regulation of mitotic spindle organization 3/982 35/18722 0.277653636842967 0.606974589175572 GNAI1/CLTC/TPX2 3 GO:0072528 pyrimidine-containing compound biosynthetic process 3/982 35/18722 0.277653636842967 0.606974589175572 NME4/DTYMK/NME1 3 GO:0097421 liver regeneration 3/982 35/18722 0.277653636842967 0.606974589175572 EGFR/GLI3/CCND1 3 GO:0098810 neurotransmitter reuptake 3/982 35/18722 0.277653636842967 0.606974589175572 SLC6A4/SLC29A1/ITGB1 3 GO:0010660 regulation of muscle cell apoptotic process 6/982 84/18722 0.278055624991249 0.607337360366178 BMP7/PPARG/LRP6/NUPR1/DNMT1/PDPK1 6 GO:0042310 vasoconstriction 6/982 84/18722 0.278055624991249 0.607337360366178 GJA1/EGFR/SLC6A4/GJA5/ADM/ATP2B1 6 GO:0009948 anterior/posterior axis specification 4/982 51/18722 0.278285331916251 0.607337360366178 WLS/PGAP1/BASP1/TBX3 4 GO:0045661 regulation of myoblast differentiation 4/982 51/18722 0.278285331916251 0.607337360366178 MBNL3/PPARD/TBX3/FLOT2 4 GO:0009308 amine metabolic process 8/982 118/18722 0.278900850618051 0.60817175452498 EPAS1/COMT/ALDH7A1/CLN3/SLC44A1/SMS/AKR1B1/AZIN1 8 GO:0034219 carbohydrate transmembrane transport 8/982 118/18722 0.278900850618051 0.60817175452498 SORBS1/SLC2A1/PRKCI/YES1/PPARD/IRS2/OPN3/SLC5A3 8 GO:0006576 cellular biogenic amine metabolic process 7/982 101/18722 0.279193070256205 0.608272733739362 EPAS1/COMT/ALDH7A1/SLC44A1/SMS/AKR1B1/AZIN1 7 GO:0007259 receptor signaling pathway via JAK-STAT 11/982 170/18722 0.280067036206177 0.608272733739362 PRLR/SOCS6/ISL1/IL6ST/FER/PIGU/IL10RB/CCL5/STAMBP/AKR1B1/LEPROT 11 GO:0045165 cell fate commitment 16/982 258/18722 0.280442852833006 0.608272733739362 NR2F2/FGFR2/ISL1/NRP1/PPARG/TEAD3/EPAS1/CTSL/ESRP1/GLI3/LMO4/TBX3/ITGB1/SMAD5/TCF7L2/RBPJ 16 GO:0000272 polysaccharide catabolic process 2/982 20/18722 0.282678893133476 0.608272733739362 GAA/AGL 2 GO:0006346 DNA methylation-dependent heterochromatin assembly 2/982 20/18722 0.282678893133476 0.608272733739362 TRIM28/DNMT1 2 GO:0006525 arginine metabolic process 2/982 20/18722 0.282678893133476 0.608272733739362 CLN3/ASS1 2 GO:0006700 C21-steroid hormone biosynthetic process 2/982 20/18722 0.282678893133476 0.608272733739362 ADM/AKR1B1 2 GO:0006896 Golgi to vacuole transport 2/982 20/18722 0.282678893133476 0.608272733739362 CLN3/EHD3 2 GO:0016553 base conversion or substitution editing 2/982 20/18722 0.282678893133476 0.608272733739362 RBM47/METTL3 2 GO:0032793 positive regulation of CREB transcription factor activity 2/982 20/18722 0.282678893133476 0.608272733739362 CD200/RPS6KA4 2 GO:0034104 negative regulation of tissue remodeling 2/982 20/18722 0.282678893133476 0.608272733739362 UBASH3B/CST3 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/982 20/18722 0.282678893133476 0.608272733739362 TOP2A/TRIM28 2 GO:0042359 vitamin D metabolic process 2/982 20/18722 0.282678893133476 0.608272733739362 LRP2/LGMN 2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 2/982 20/18722 0.282678893133476 0.608272733739362 BACE2/ITM2C 2 GO:0043011 myeloid dendritic cell differentiation 2/982 20/18722 0.282678893133476 0.608272733739362 ITGB8/RBPJ 2 GO:0043586 tongue development 2/982 20/18722 0.282678893133476 0.608272733739362 EGFR/GLI3 2 GO:0043651 linoleic acid metabolic process 2/982 20/18722 0.282678893133476 0.608272733739362 CYP2J2/GSTP1 2 GO:0046931 pore complex assembly 2/982 20/18722 0.282678893133476 0.608272733739362 NUP153/BAD 2 GO:0051900 regulation of mitochondrial depolarization 2/982 20/18722 0.282678893133476 0.608272733739362 IFI6/GCLM 2 GO:0060044 negative regulation of cardiac muscle cell proliferation 2/982 20/18722 0.282678893133476 0.608272733739362 GJA1/VGLL4 2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 2/982 20/18722 0.282678893133476 0.608272733739362 YTHDF2/METTL3 2 GO:0061318 renal filtration cell differentiation 2/982 20/18722 0.282678893133476 0.608272733739362 CD24/BASP1 2 GO:0071397 cellular response to cholesterol 2/982 20/18722 0.282678893133476 0.608272733739362 DAG1/LRP6 2 GO:0071625 vocalization behavior 2/982 20/18722 0.282678893133476 0.608272733739362 SHANK2/GLI3 2 GO:0072112 glomerular visceral epithelial cell differentiation 2/982 20/18722 0.282678893133476 0.608272733739362 CD24/BASP1 2 GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/982 20/18722 0.282678893133476 0.608272733739362 TRIAP1/LMNA 2 GO:0097150 neuronal stem cell population maintenance 2/982 20/18722 0.282678893133476 0.608272733739362 ASPM/HOOK3 2 GO:0098543 detection of other organism 2/982 20/18722 0.282678893133476 0.608272733739362 HLA-B/HLA-A 2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/982 20/18722 0.282678893133476 0.608272733739362 WFS1/CREB3 2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/982 20/18722 0.282678893133476 0.608272733739362 MET/PINK1 2 GO:1904292 regulation of ERAD pathway 2/982 20/18722 0.282678893133476 0.608272733739362 USP14/USP25 2 GO:2000678 negative regulation of transcription regulatory region DNA binding 2/982 20/18722 0.282678893133476 0.608272733739362 TMSB4X/ZNF593 2 GO:0070371 ERK1 and ERK2 cascade 20/982 330/18722 0.284023515830707 0.610914086009471 SEMA6A/EGFR/ITGAV/LRP1/APP/FGFR2/TPBG/NRP1/WNK2/GCNT2/FBLN1/DUSP9/HRAS/TIMP3/FERMT2/P2RY6/CCL5/PDGFA/DUSP6/GSTP1 20 GO:0034394 protein localization to cell surface 5/982 68/18722 0.284730996616934 0.611931140648508 PTPRK/JAM3/PIGU/TM9SF4/LEPROT 5 GO:0042267 natural killer cell mediated cytotoxicity 5/982 68/18722 0.284730996616934 0.611931140648508 CADM1/HLA-B/HLA-A/HLA-E/PRDX1 5 GO:0042129 regulation of T cell proliferation 11/982 171/18722 0.286414249223275 0.615295191082621 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/CD24/HLA-E/CCL5 11 GO:0010507 negative regulation of autophagy 6/982 85/18722 0.287183786133049 0.616187012945283 MET/TAB3/PINK1/NUPR1/RRAGA/PHF23 6 GO:0030433 ubiquitin-dependent ERAD pathway 6/982 85/18722 0.287183786133049 0.616187012945283 WFS1/UBE4B/TMUB1/HSP90B1/USP14/FAF2 6 GO:0055072 iron ion homeostasis 6/982 85/18722 0.287183786133049 0.616187012945283 TFRC/ACO1/EPAS1/B2M/SLC40A1/SLC11A2 6 GO:0140694 non-membrane-bounded organelle assembly 22/982 367/18722 0.28899224671716 0.619812318617066 OBSL1/ASPM/CDS1/SQLE/CENPF/CSRP2/RACGAP1/RPF2/YTHDF2/TRIM37/PUM2/ITGB1/PLK2/CENPW/TPX2/GSN/RPL10/CEP152/KRT8/KIF4A/SAC3D1/CEP135 22 GO:0030514 negative regulation of BMP signaling pathway 4/982 52/18722 0.290169791168242 0.62157110091727 LRP2/FBN1/PPARG/CRIM1 4 GO:0043277 apoptotic cell clearance 4/982 52/18722 0.290169791168242 0.62157110091727 ITGAV/LRP1/TGM2/RHOBTB1 4 GO:2000378 negative regulation of reactive oxygen species metabolic process 4/982 52/18722 0.290169791168242 0.62157110091727 TFAP2A/PAGE4/HDAC6/PINK1 4 GO:0017004 cytochrome complex assembly 3/982 36/18722 0.292174807340687 0.623306255660132 CYBA/SCO1/SURF1 3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/982 36/18722 0.292174807340687 0.623306255660132 LRP1/PPARD/BAD 3 GO:0036314 response to sterol 3/982 36/18722 0.292174807340687 0.623306255660132 DAG1/LRP6/INSIG1 3 GO:0042119 neutrophil activation 3/982 36/18722 0.292174807340687 0.623306255660132 CCL5/GRN/ANXA3 3 GO:0045738 negative regulation of DNA repair 3/982 36/18722 0.292174807340687 0.623306255660132 POLQ/RMI2/MAGEF1 3 GO:0051385 response to mineralocorticoid 3/982 36/18722 0.292174807340687 0.623306255660132 ATP2B1/CCND1/CYBA 3 GO:0060338 regulation of type I interferon-mediated signaling pathway 3/982 36/18722 0.292174807340687 0.623306255660132 TRIM6/YTHDF2/METTL3 3 GO:0071402 cellular response to lipoprotein particle stimulus 3/982 36/18722 0.292174807340687 0.623306255660132 PPARG/LDLR/ITGB1 3 GO:1903539 protein localization to postsynaptic membrane 3/982 36/18722 0.292174807340687 0.623306255660132 DAG1/HRAS/NSG1 3 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 3/982 36/18722 0.292174807340687 0.623306255660132 PINK1/LEPROT/HUWE1 3 GO:1901136 carbohydrate derivative catabolic process 11/982 172/18722 0.292802836812681 0.624390677356886 GPC1/NAGLU/CTSL/GNS/NUDT4/MANBA/FUCA1/CST3/PDE7A/NEU1/GUSB 11 GO:0050670 regulation of lymphocyte proliferation 14/982 225/18722 0.293487377343161 0.625594671116439 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2 14 GO:0032411 positive regulation of transporter activity 8/982 120/18722 0.29426003734889 0.626985439057113 TCAF1/WNK2/TMSB4X/P2RY6/PINK1/RXRA/ANK3/EHD3 8 GO:0003143 embryonic heart tube morphogenesis 5/982 69/18722 0.295029129088062 0.627598669381457 YAP1/FOLR1/TBX3/NPHP3/AHI1 5 GO:0050688 regulation of defense response to virus 5/982 69/18722 0.295029129088062 0.627598669381457 EIF2AK4/ELMOD2/TRIM6/TSPAN6/DHX9 5 GO:0050805 negative regulation of synaptic transmission 5/982 69/18722 0.295029129088062 0.627598669381457 SLC6A4/SHANK2/PPP1R9A/GNAI1/PLK2 5 GO:1901224 positive regulation of NIK/NF-kappaB signaling 5/982 69/18722 0.295029129088062 0.627598669381457 EGFR/APP/NFAT5/TRIP6/EDARADD 5 GO:0030593 neutrophil chemotaxis 7/982 103/18722 0.295855954662407 0.628844604531016 CSF3R/JAM3/CCL5/MPP1/VAV3/DPP4/BSG 7 GO:1905037 autophagosome organization 7/982 103/18722 0.295855954662407 0.628844604531016 WIPI2/CLN3/PINK1/TBC1D12/NUPR1/GABARAPL1/PHF23 7 GO:0010970 transport along microtubule 10/982 155/18722 0.296113341545038 0.62910418568524 DST/APP/MREG/ARHGAP21/CLN3/HDAC6/ARMCX3/IFT74/FLOT2/KIF4A 10 GO:0009798 axis specification 6/982 86/18722 0.296374548181428 0.62910418568524 WLS/COBL/PGAP1/BASP1/TBX3/AHI1 6 GO:0034103 regulation of tissue remodeling 6/982 86/18722 0.296374548181428 0.62910418568524 EGFR/SYT7/TFRC/UBASH3B/NF1/CST3 6 GO:0045936 negative regulation of phosphate metabolic process 26/982 441/18722 0.296460523085567 0.62910418568524 PLPP3/NR2F2/LRP1/LRP5/BMP7/UBASH3B/SWAP70/FBLN1/PPARG/NF1/LRP6/LATS2/CDKN1C/CTDSPL/PARD3/CEBPA/TARDBP/PDGFA/MLLT1/PKIB/DUSP6/NUPR1/GSTP1/IRS2/TRIM27/PDPK1 26 GO:0055074 calcium ion homeostasis 27/982 460/18722 0.299900319984646 0.632060702086999 GJA1/ITGAV/LRP1/MCOLN3/APP/ATP6V1B1/UBASH3B/SWAP70/CHD7/LRP6/TRPV6/ADM/WFS1/ATP2B1/TGM2/ATP13A3/CD24/CLN3/P2RY6/C1QTNF1/TRIM24/CCL5/CYBA/CD52/AFG3L2/HSP90B1/PDPK1 27 GO:0010563 negative regulation of phosphorus metabolic process 26/982 442/18722 0.300469721525356 0.632060702086999 PLPP3/NR2F2/LRP1/LRP5/BMP7/UBASH3B/SWAP70/FBLN1/PPARG/NF1/LRP6/LATS2/CDKN1C/CTDSPL/PARD3/CEBPA/TARDBP/PDGFA/MLLT1/PKIB/DUSP6/NUPR1/GSTP1/IRS2/TRIM27/PDPK1 26 GO:0002707 negative regulation of lymphocyte mediated immunity 4/982 53/18722 0.302121205486186 0.632060702086999 CD46/HLA-B/HLA-A/HLA-E 4 GO:0032784 regulation of DNA-templated transcription, elongation 4/982 53/18722 0.302121205486186 0.632060702086999 BRD4/ELL/WDR43/ZNF326 4 GO:2000772 regulation of cellular senescence 4/982 53/18722 0.302121205486186 0.632060702086999 PAWR/B2M/CDK6/PLK2 4 GO:0000002 mitochondrial genome maintenance 2/982 21/18722 0.302458495477214 0.632060702086999 SLC25A36/SLC25A4 2 GO:0003177 pulmonary valve development 2/982 21/18722 0.302458495477214 0.632060702086999 GJA5/RBPJ 2 GO:0007063 regulation of sister chromatid cohesion 2/982 21/18722 0.302458495477214 0.632060702086999 AXIN2/FEN1 2 GO:0007252 I-kappaB phosphorylation 2/982 21/18722 0.302458495477214 0.632060702086999 MAP3K7/PRDX4 2 GO:0010878 cholesterol storage 2/982 21/18722 0.302458495477214 0.632060702086999 PPARG/PPARD 2 GO:0030449 regulation of complement activation 2/982 21/18722 0.302458495477214 0.632060702086999 CD46/CD59 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/982 21/18722 0.302458495477214 0.632060702086999 SLC26A2/SLC35B2 2 GO:0038083 peptidyl-tyrosine autophosphorylation 2/982 21/18722 0.302458495477214 0.632060702086999 EGFR/IGF1R 2 GO:0044241 lipid digestion 2/982 21/18722 0.302458495477214 0.632060702086999 LDLR/LIMA1 2 GO:0044342 type B pancreatic cell proliferation 2/982 21/18722 0.302458495477214 0.632060702086999 NUPR1/BAD 2 GO:0044766 multi-organism transport 2/982 21/18722 0.302458495477214 0.632060702086999 CTSL/NUP153 2 GO:0045717 negative regulation of fatty acid biosynthetic process 2/982 21/18722 0.302458495477214 0.632060702086999 ACADVL/INSIG1 2 GO:0046519 sphingoid metabolic process 2/982 21/18722 0.302458495477214 0.632060702086999 PLPP3/SPTLC3 2 GO:0046599 regulation of centriole replication 2/982 21/18722 0.302458495477214 0.632060702086999 TRIM37/PLK2 2 GO:0046641 positive regulation of alpha-beta T cell proliferation 2/982 21/18722 0.302458495477214 0.632060702086999 HLA-A/HLA-E 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/982 21/18722 0.302458495477214 0.632060702086999 FERMT1/NUP153 2 GO:0048199 vesicle targeting, to, from or within Golgi 2/982 21/18722 0.302458495477214 0.632060702086999 TFG/TMED9 2 GO:0048714 positive regulation of oligodendrocyte differentiation 2/982 21/18722 0.302458495477214 0.632060702086999 DAG1/PTN 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/982 21/18722 0.302458495477214 0.632060702086999 SLC26A2/SLC35B2 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/982 21/18722 0.302458495477214 0.632060702086999 DDX1/BCL10 2 GO:0071498 cellular response to fluid shear stress 2/982 21/18722 0.302458495477214 0.632060702086999 MTSS1/ASS1 2 GO:0072170 metanephric tubule development 2/982 21/18722 0.302458495477214 0.632060702086999 LGR4/YAP1 2 GO:0072243 metanephric nephron epithelium development 2/982 21/18722 0.302458495477214 0.632060702086999 LGR4/YAP1 2 GO:0072311 glomerular epithelial cell differentiation 2/982 21/18722 0.302458495477214 0.632060702086999 CD24/BASP1 2 GO:0090141 positive regulation of mitochondrial fission 2/982 21/18722 0.302458495477214 0.632060702086999 MIEF1/PINK1 2 GO:0097062 dendritic spine maintenance 2/982 21/18722 0.302458495477214 0.632060702086999 CTTN/IGF1R 2 GO:0098856 intestinal lipid absorption 2/982 21/18722 0.302458495477214 0.632060702086999 LDLR/LIMA1 2 GO:1902259 regulation of delayed rectifier potassium channel activity 2/982 21/18722 0.302458495477214 0.632060702086999 KCNG1/ANK3 2 GO:1902307 positive regulation of sodium ion transmembrane transport 2/982 21/18722 0.302458495477214 0.632060702086999 WNK2/ANK3 2 GO:1902473 regulation of protein localization to synapse 2/982 21/18722 0.302458495477214 0.632060702086999 DAG1/HRAS 2 GO:1902579 multi-organism localization 2/982 21/18722 0.302458495477214 0.632060702086999 CTSL/NUP153 2 GO:2000291 regulation of myoblast proliferation 2/982 21/18722 0.302458495477214 0.632060702086999 PPARD/MALAT1 2 GO:2000774 positive regulation of cellular senescence 2/982 21/18722 0.302458495477214 0.632060702086999 PAWR/B2M 2 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 13/982 209/18722 0.303395365742619 0.633764608615739 PPARG/DHCR24/IFI6/MDM2/TRIAP1/BCL2L13/USP47/BIRC5/GSN/PRDX5/BAD/NLRP2/BCL10 13 GO:1901890 positive regulation of cell junction assembly 7/982 104/18722 0.304268148966806 0.635333332670481 VSTM5/TPBG/NRP1/DLG5/CLDN19/FERMT2/MAP4K4 7 GO:0032944 regulation of mononuclear cell proliferation 14/982 227/18722 0.304733829253083 0.636051081786348 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2 14 GO:0001990 regulation of systemic arterial blood pressure by hormone 3/982 37/18722 0.306744616093563 0.637696260479883 ENPEP/MME/CYBA 3 GO:0002369 T cell cytokine production 3/982 37/18722 0.306744616093563 0.637696260479883 B2M/HLA-A/MAP3K7 3 GO:0002724 regulation of T cell cytokine production 3/982 37/18722 0.306744616093563 0.637696260479883 B2M/HLA-A/MAP3K7 3 GO:0033260 nuclear DNA replication 3/982 37/18722 0.306744616093563 0.637696260479883 MCM2/FEN1/BRCA2 3 GO:0050775 positive regulation of dendrite morphogenesis 3/982 37/18722 0.306744616093563 0.637696260479883 OBSL1/ANKRD27/CUX1 3 GO:0051294 establishment of spindle orientation 3/982 37/18722 0.306744616093563 0.637696260479883 GJA1/SPDL1/ITGB1 3 GO:0060416 response to growth hormone 3/982 37/18722 0.306744616093563 0.637696260479883 PTK2/LEPROT/ASS1 3 GO:0062237 protein localization to postsynapse 3/982 37/18722 0.306744616093563 0.637696260479883 DAG1/HRAS/NSG1 3 GO:0090218 positive regulation of lipid kinase activity 3/982 37/18722 0.306744616093563 0.637696260479883 FLT1/PTK2/VAV3 3 GO:1905332 positive regulation of morphogenesis of an epithelium 3/982 37/18722 0.306744616093563 0.637696260479883 GJA1/LGR4/MAGED1 3 GO:0062207 regulation of pattern recognition receptor signaling pathway 7/982 105/18722 0.312727868542389 0.649875921241872 LGR4/PUM1/ZCCHC3/CYBA/TSPAN6/PUM2/PDPK1 7 GO:0030520 intracellular estrogen receptor signaling pathway 4/982 54/18722 0.314126048752599 0.65226173180476 SKP2/ISL1/YAP1/UBA5 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/982 54/18722 0.314126048752599 0.65226173180476 LRP2/ADGRG1/ASPM/GLI3 4 GO:0002228 natural killer cell mediated immunity 5/982 71/18722 0.315800011383571 0.654175083151989 CADM1/HLA-B/HLA-A/HLA-E/PRDX1 5 GO:0008344 adult locomotory behavior 5/982 71/18722 0.315800011383571 0.654175083151989 APP/ABHD12/CHD7/PUM1/EPS8 5 GO:0043550 regulation of lipid kinase activity 5/982 71/18722 0.315800011383571 0.654175083151989 SOCS6/SOCS7/FLT1/PTK2/VAV3 5 GO:0050795 regulation of behavior 5/982 71/18722 0.315800011383571 0.654175083151989 GJA1/ADRB1/ZFHX3/EIF2AK4/AHI1 5 GO:0050818 regulation of coagulation 5/982 71/18722 0.315800011383571 0.654175083151989 UBASH3B/ANXA5/C1QTNF1/PDGFA/ANXA2 5 GO:0061515 myeloid cell development 5/982 71/18722 0.315800011383571 0.654175083151989 FBN1/APP/SLC11A2/ALAS1/ANXA2 5 GO:0071695 anatomical structure maturation 14/982 229/18722 0.316098226890034 0.654532890614696 PLXNB1/DAG1/APP/FERMT1/PPARG/EPAS1/CEBPA/YTHDF2/MAP3K13/XYLT1/BRCA2/AKR1B1/RERE/RBPJ 14 GO:0043534 blood vessel endothelial cell migration 11/982 176/18722 0.318729328445531 0.657127732190696 NRP1/PPARG/NF1/AMOT/ID1/TMSB4X/EFNA1/EPHB4/ITGB1/PLK2/PDPK1 11 GO:0030258 lipid modification 13/982 212/18722 0.321188500516702 0.657127732190696 PLPP3/SLC27A2/ACADS/SYNJ1/ECI1/PPARD/ACADVL/SLC25A17/DECR2/ECHDC2/IRS2/INPPL1/HADHB 13 GO:0006906 vesicle fusion 7/982 106/18722 0.321230398889098 0.657127732190696 SYT7/ANKRD27/RAB13/CLN3/TBC1D4/VAV3/ANXA2 7 GO:0035821 modulation of process of other organism 7/982 106/18722 0.321230398889098 0.657127732190696 DAG1/EIF2AK4/TARDBP/CCL5/RXRA/RRAGA/TAF11 7 GO:0000578 embryonic axis specification 3/982 38/18722 0.321339978683574 0.657127732190696 COBL/BASP1/TBX3 3 GO:0008210 estrogen metabolic process 3/982 38/18722 0.321339978683574 0.657127732190696 HSD17B1/COMT/HSD17B12 3 GO:0009595 detection of biotic stimulus 3/982 38/18722 0.321339978683574 0.657127732190696 YAP1/HLA-B/HLA-A 3 GO:0032941 secretion by tissue 3/982 38/18722 0.321339978683574 0.657127732190696 EGFR/KCNN4/CYBA 3 GO:0035136 forelimb morphogenesis 3/982 38/18722 0.321339978683574 0.657127732190696 RDH10/TFAP2A/TBX3 3 GO:0046329 negative regulation of JNK cascade 3/982 38/18722 0.321339978683574 0.657127732190696 MARVELD3/PINK1/GSTP1 3 GO:0071392 cellular response to estradiol stimulus 3/982 38/18722 0.321339978683574 0.657127732190696 EGFR/NCOA3/CCNA2 3 GO:0071398 cellular response to fatty acid 3/982 38/18722 0.321339978683574 0.657127732190696 LDLR/NME1/ASS1 3 GO:0030595 leukocyte chemotaxis 14/982 230/18722 0.321821199347539 0.657127732190696 CSF3R/SWAP70/PTN/JAM3/FLT1/PTK2/CCL5/MPP1/LGMN/VAV3/DPP4/CREB3/BSG/PGF 14 GO:0045333 cellular respiration 14/982 230/18722 0.321821199347539 0.657127732190696 ACO1/SLC25A13/ADSL/IL10RB/CYC1/PINK1/IDH1/NUPR1/DHTKD1/COX6A1/SUCLA2/FH/OPN3/SURF1 14 GO:0006907 pinocytosis 2/982 22/18722 0.32213872914333 0.657127732190696 PROM2/CLN3 2 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 2/982 22/18722 0.32213872914333 0.657127732190696 SPESP1/FOLR1 2 GO:0007413 axonal fasciculation 2/982 22/18722 0.32213872914333 0.657127732190696 NRP1/TNFRSF21 2 GO:0009220 pyrimidine ribonucleotide biosynthetic process 2/982 22/18722 0.32213872914333 0.657127732190696 NME4/NME1 2 GO:0010310 regulation of hydrogen peroxide metabolic process 2/982 22/18722 0.32213872914333 0.657127732190696 HDAC6/PINK1 2 GO:0021854 hypothalamus development 2/982 22/18722 0.32213872914333 0.657127732190696 NRP2/NRP1 2 GO:0032069 regulation of nuclease activity 2/982 22/18722 0.32213872914333 0.657127732190696 ABCE1/DFFA 2 GO:0032402 melanosome transport 2/982 22/18722 0.32213872914333 0.657127732190696 MREG/RAB17 2 GO:0032891 negative regulation of organic acid transport 2/982 22/18722 0.32213872914333 0.657127732190696 SLC43A2/IRS2 2 GO:0033617 mitochondrial cytochrome c oxidase assembly 2/982 22/18722 0.32213872914333 0.657127732190696 SCO1/SURF1 2 GO:0034755 iron ion transmembrane transport 2/982 22/18722 0.32213872914333 0.657127732190696 SLC40A1/SLC11A2 2 GO:0035089 establishment of apical/basal cell polarity 2/982 22/18722 0.32213872914333 0.657127732190696 FAT1/PRKCI 2 GO:0035268 protein mannosylation 2/982 22/18722 0.32213872914333 0.657127732190696 TMTC3/B4GAT1 2 GO:0035357 peroxisome proliferator activated receptor signaling pathway 2/982 22/18722 0.32213872914333 0.657127732190696 PPARG/RXRA 2 GO:0035809 regulation of urine volume 2/982 22/18722 0.32213872914333 0.657127732190696 ADM/AKR1B1 2 GO:0048169 regulation of long-term neuronal synaptic plasticity 2/982 22/18722 0.32213872914333 0.657127732190696 APP/HRAS 2 GO:0051151 negative regulation of smooth muscle cell differentiation 2/982 22/18722 0.32213872914333 0.657127732190696 FOXO4/DNMT1 2 GO:0051412 response to corticosterone 2/982 22/18722 0.32213872914333 0.657127732190696 ATP2B1/CCND1 2 GO:0060563 neuroepithelial cell differentiation 2/982 22/18722 0.32213872914333 0.657127732190696 SOX4/DLX3 2 GO:0097164 ammonium ion metabolic process 2/982 22/18722 0.32213872914333 0.657127732190696 ALDH7A1/SLC44A1 2 GO:0106030 neuron projection fasciculation 2/982 22/18722 0.32213872914333 0.657127732190696 NRP1/TNFRSF21 2 GO:0140467 integrated stress response signaling 2/982 22/18722 0.32213872914333 0.657127732190696 EIF2AK4/TMEM33 2 GO:1901032 negative regulation of response to reactive oxygen species 2/982 22/18722 0.32213872914333 0.657127732190696 MET/PINK1 2 GO:2000773 negative regulation of cellular senescence 2/982 22/18722 0.32213872914333 0.657127732190696 CDK6/PLK2 2 GO:0009199 ribonucleoside triphosphate metabolic process 6/982 89/18722 0.324259461815136 0.6609368318983 SLC25A13/TMSB4X/PINK1/NME4/IMPDH2/NME1 6 GO:0010657 muscle cell apoptotic process 6/982 89/18722 0.324259461815136 0.6609368318983 BMP7/PPARG/LRP6/NUPR1/DNMT1/PDPK1 6 GO:0002067 glandular epithelial cell differentiation 4/982 55/18722 0.326171140677413 0.66215851305448 FGFR2/CDK6/BAD/PDPK1 4 GO:0003179 heart valve morphogenesis 4/982 55/18722 0.326171140677413 0.66215851305448 GJA5/SOX4/EFNA1/MDM2 4 GO:0008333 endosome to lysosome transport 4/982 55/18722 0.326171140677413 0.66215851305448 HOOK2/HOOK1/VIPAS39/HOOK3 4 GO:0042220 response to cocaine 4/982 55/18722 0.326171140677413 0.66215851305448 SLC1A3/TGM2/MDM2/CCNA2 4 GO:0043331 response to dsRNA 4/982 55/18722 0.326171140677413 0.66215851305448 COLEC12/ZCCHC3/DHX9/DDX1 4 GO:0044091 membrane biogenesis 4/982 55/18722 0.326171140677413 0.66215851305448 PACSIN2/ANK3/FLOT2/ANXA2 4 GO:0061098 positive regulation of protein tyrosine kinase activity 4/982 55/18722 0.326171140677413 0.66215851305448 ERBB3/EFNA1/CD24/CCL5 4 GO:1905517 macrophage migration 4/982 55/18722 0.326171140677413 0.66215851305448 CD200/MMP14/PTK2/CCL5 4 GO:0001736 establishment of planar polarity 5/982 72/18722 0.326255248955141 0.66215851305448 DVL3/ZNRF3/DAB2/FZD6/NPHP3 5 GO:0007164 establishment of tissue polarity 5/982 72/18722 0.326255248955141 0.66215851305448 DVL3/ZNRF3/DAB2/FZD6/NPHP3 5 GO:0033045 regulation of sister chromatid segregation 5/982 72/18722 0.326255248955141 0.66215851305448 CENPF/ZWINT/SPDL1/RMI2/LCMT1 5 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 7/982 107/18722 0.329771048121859 0.669033756127428 DAB2/PTK2/CEBPA/MDM2/MAGEF1/PLK2/FBXO22 7 GO:0051348 negative regulation of transferase activity 16/982 268/18722 0.332979516259439 0.675280387561911 NR2F2/LRP5/BMP7/UBASH3B/PPARG/NF1/LRP6/LATS2/CDKN1C/CEBPA/MLLT1/PKIB/GSTP1/IRS2/TRIM27/PDPK1 16 GO:0055007 cardiac muscle cell differentiation 8/982 125/18722 0.333448579631 0.675564913973984 OBSL1/ISL1/PARP2/TBX3/LMNA/ITGB1/CBY1/RBPJ 8 GO:0071621 granulocyte chemotaxis 8/982 125/18722 0.333448579631 0.675564913973984 CSF3R/JAM3/PTK2/CCL5/MPP1/VAV3/DPP4/BSG 8 GO:0030901 midbrain development 6/982 90/18722 0.333637886962612 0.675564913973984 WLS/FGFR2/DLG5/LRP6/BASP1/FZD6 6 GO:0048477 oogenesis 6/982 90/18722 0.333637886962612 0.675564913973984 LGR5/PTN/ASPM/YTHDF2/BRCA2/METTL3 6 GO:0042110 T cell activation 28/982 487/18722 0.334647036570639 0.677345340610188 SOCS6/SOX4/TFRC/PAWR/GPR89A/PTPRK/EIF2AK4/IL6ST/GPAM/CHD7/DLG5/B2M/TNFRSF21/CTSL/CD46/HLA-A/GLI3/YES1/CD24/HLA-E/CCL5/METTL3/DPP4/GSN/FLOT2/BAD/DDOST/BCL10 28 GO:0045923 positive regulation of fatty acid metabolic process 3/982 39/18722 0.335938943330886 0.678906442624526 PPARG/PPARD/IRS2 3 GO:0071548 response to dexamethasone 3/982 39/18722 0.335938943330886 0.678906442624526 EGFR/SERPINF1/ASS1 3 GO:0090224 regulation of spindle organization 3/982 39/18722 0.335938943330886 0.678906442624526 GNAI1/CLTC/TPX2 3 GO:1902742 apoptotic process involved in development 3/982 39/18722 0.335938943330886 0.678906442624526 LRP5/BMP7/FOXC1 3 GO:0045739 positive regulation of DNA repair 5/982 73/18722 0.336745573651064 0.679746483035585 EGFR/BRCC3/DHX9/WDR48/TRIM28 5 GO:0051145 smooth muscle cell differentiation 5/982 73/18722 0.336745573651064 0.679746483035585 FGFR2/ADM/FOXO4/TBX3/DNMT1 5 GO:0061035 regulation of cartilage development 5/982 73/18722 0.336745573651064 0.679746483035585 SCIN/EFEMP1/GLI3/AXIN2/GLG1 5 GO:0045071 negative regulation of viral genome replication 4/982 56/18722 0.338243668614612 0.681191202730915 TRIM6/CCL5/TRIM28/SRPK1 4 GO:0048008 platelet-derived growth factor receptor signaling pathway 4/982 56/18722 0.338243668614612 0.681191202730915 LRP1/NRP1/FER/PDGFA 4 GO:0055078 sodium ion homeostasis 4/982 56/18722 0.338243668614612 0.681191202730915 ATP6V1B1/SLC1A3/COMT/EXT2 4 GO:0022037 metencephalon development 7/982 108/18722 0.338345153755745 0.681191202730915 NAGLU/SEMA4C/PTN/PDSS2/RERE/FOXC1/ATIC 7 GO:0033138 positive regulation of peptidyl-serine phosphorylation 7/982 108/18722 0.338345153755745 0.681191202730915 EGFR/APP/TFRC/TRIM6/HDAC6/BCAR3/PINK1 7 GO:0006941 striated muscle contraction 11/982 179/18722 0.338506057798798 0.681191202730915 GJA1/GJA5/DSG2/DSP/DSC2/GAA/ARHGEF11/PKP2/GSN/SMAD5/EHD3 11 GO:0007416 synapse assembly 11/982 179/18722 0.338506057798798 0.681191202730915 PLXNB1/CDH1/OBSL1/APP/VSTM5/TPBG/SHANK2/DLG5/PPP1R9A/PLXNB2/RAB17 11 GO:0010950 positive regulation of endopeptidase activity 11/982 179/18722 0.338506057798798 0.681191202730915 PPARG/ASPH/PERP/EFNA1/LGMN/BCL2L13/PSME3/GSN/BAD/NLRP2/BCL10 11 GO:0042594 response to starvation 12/982 197/18722 0.339039399267815 0.682001352325848 CTSV/EIF2AK4/SLC2A1/WIPI2/ADM/ADSL/TFEB/PAGE4/COMT/GABARAPL1/SLC38A2/RRAGA 12 GO:0002052 positive regulation of neuroblast proliferation 2/982 23/18722 0.341675633376584 0.682304787018478 ASPM/GLI3 2 GO:0002082 regulation of oxidative phosphorylation 2/982 23/18722 0.341675633376584 0.682304787018478 PINK1/NUPR1 2 GO:0016578 histone deubiquitination 2/982 23/18722 0.341675633376584 0.682304787018478 BRCC3/ENY2 2 GO:0019430 removal of superoxide radicals 2/982 23/18722 0.341675633376584 0.682304787018478 BMP7/PRDX1 2 GO:0030325 adrenal gland development 2/982 23/18722 0.341675633376584 0.682304787018478 PBX1/NF1 2 GO:0032401 establishment of melanosome localization 2/982 23/18722 0.341675633376584 0.682304787018478 MREG/RAB17 2 GO:0034695 response to prostaglandin E 2/982 23/18722 0.341675633376584 0.682304787018478 TGFBR3/P2RY6 2 GO:0035812 renal sodium excretion 2/982 23/18722 0.341675633376584 0.682304787018478 ATP6V1B1/COMT 2 GO:0035988 chondrocyte proliferation 2/982 23/18722 0.341675633376584 0.682304787018478 MMP14/GOLGB1 2 GO:0035994 response to muscle stretch 2/982 23/18722 0.341675633376584 0.682304787018478 PTK2/GSN 2 GO:0043931 ossification involved in bone maturation 2/982 23/18722 0.341675633376584 0.682304787018478 PLXNB1/XYLT1 2 GO:0045943 positive regulation of transcription by RNA polymerase I 2/982 23/18722 0.341675633376584 0.682304787018478 WDR43/HEATR1 2 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 2/982 23/18722 0.341675633376584 0.682304787018478 CHPF/XYLT1 2 GO:0051882 mitochondrial depolarization 2/982 23/18722 0.341675633376584 0.682304787018478 IFI6/GCLM 2 GO:0060396 growth hormone receptor signaling pathway 2/982 23/18722 0.341675633376584 0.682304787018478 PTK2/LEPROT 2 GO:0060547 negative regulation of necrotic cell death 2/982 23/18722 0.341675633376584 0.682304787018478 SLC25A4/NUPR1 2 GO:0071218 cellular response to misfolded protein 2/982 23/18722 0.341675633376584 0.682304787018478 UGGT2/HDAC6 2 GO:0090208 positive regulation of triglyceride metabolic process 2/982 23/18722 0.341675633376584 0.682304787018478 LDLR/PNPLA2 2 GO:2001169 regulation of ATP biosynthetic process 2/982 23/18722 0.341675633376584 0.682304787018478 TMSB4X/PINK1 2 GO:0055006 cardiac cell development 6/982 91/18722 0.34304781592502 0.684782781425527 OBSL1/ISL1/PARP2/TGFBR3/TBX3/LMNA 6 GO:0021953 central nervous system neuron differentiation 10/982 162/18722 0.344520381953628 0.687459186025297 NRP2/FGFR2/ISL1/SOX4/NRP1/NFIB/B2M/TSKU/GLI3/LMO4 10 GO:0048167 regulation of synaptic plasticity 12/982 198/18722 0.345370957293034 0.688892892252569 APP/SHANK2/SYT7/MME/EIF2AK4/PTN/PPP1R9A/HRAS/NSG1/CLN3/LGMN/PLK2 12 GO:0006821 chloride transport 7/982 109/18722 0.346948089202719 0.690553453280316 SLC26A2/GABRE/CLDN4/SLC1A3/FXYD3/P2RY6/CLIC4 7 GO:0032414 positive regulation of ion transmembrane transporter activity 7/982 109/18722 0.346948089202719 0.690553453280316 TCAF1/WNK2/TMSB4X/P2RY6/PINK1/ANK3/EHD3 7 GO:0006801 superoxide metabolic process 5/982 74/18722 0.347262597383871 0.690553453280316 EGFR/BMP7/CYBA/PRDX1/GSTP1 5 GO:0030968 endoplasmic reticulum unfolded protein response 5/982 74/18722 0.347262597383871 0.690553453280316 WFS1/CCND1/TMEM33/CREB3L2/CREB3 5 GO:0046323 glucose import 5/982 74/18722 0.347262597383871 0.690553453280316 SORBS1/SLC2A1/PRKCI/IRS2/OPN3 5 GO:0046470 phosphatidylcholine metabolic process 5/982 74/18722 0.347262597383871 0.690553453280316 CDS1/LDLR/RAB38/CHPT1/SLC44A1 5 GO:0051881 regulation of mitochondrial membrane potential 5/982 74/18722 0.347262597383871 0.690553453280316 SLC25A36/IFI6/PINK1/GCLM/BAD 5 GO:0070972 protein localization to endoplasmic reticulum 5/982 74/18722 0.347262597383871 0.690553453280316 GJA1/TRAM2/INSIG1/GPAA1/SEC63 5 GO:0016311 dephosphorylation 24/982 417/18722 0.348655545785829 0.693059194671831 PLPP3/TNS3/PTPN14/UBASH3B/PTPRK/SWAP70/PDP2/CAMK2G/CTDSPL/SYNJ1/PPP4R1/PTPRF/SLC39A10/PPP1R3E/CPPED1/PPM1H/PHLPP1/PINK1/DUSP6/DUSP5/PPP2CB/DUSP14/INPPL1/HSP90B1 24 GO:0051224 negative regulation of protein transport 8/982 127/18722 0.34936260497909 0.694200132407974 CD200/FERMT1/FRMD4A/LMAN1/MAP4K4/INSIG1/LYPLA1/ENY2 8 GO:0002011 morphogenesis of an epithelial sheet 4/982 57/18722 0.350331206396532 0.694648917258463 DAG1/BMP7/FERMT1/FERMT2 4 GO:0097120 receptor localization to synapse 4/982 57/18722 0.350331206396532 0.694648917258463 DAG1/HRAS/NSG1/ZDHHC3 4 GO:1902017 regulation of cilium assembly 4/982 57/18722 0.350331206396532 0.694648917258463 YAP1/LIMK2/SDCCAG8/CEP135 4 GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/982 40/18722 0.35052069597858 0.694648917258463 HDAC6/CAMSAP2/TPX2 3 GO:0032094 response to food 3/982 40/18722 0.35052069597858 0.694648917258463 SLC16A1/NENF/BCL10 3 GO:0072210 metanephric nephron development 3/982 40/18722 0.35052069597858 0.694648917258463 LGR4/IRX2/KIF26B 3 GO:1901223 negative regulation of NIK/NF-kappaB signaling 3/982 40/18722 0.35052069597858 0.694648917258463 BMP7/TMSB4X/TSPAN6 3 GO:0002699 positive regulation of immune effector process 14/982 235/18722 0.350787800551683 0.694914230033262 CADM1/TFRC/FER/B2M/CD46/HLA-B/HLA-A/TRIM6/SNX4/MAP3K7/HLA-E/PDPK1/DDX1/BCL10 14 GO:0031058 positive regulation of histone modification 6/982 92/18722 0.352483227348997 0.697742889507539 ISL1/BRD4/PINK1/LMNA/RPS6KA4/DNMT1 6 GO:0048525 negative regulation of viral process 6/982 92/18722 0.352483227348997 0.697742889507539 TRIM6/CCL5/TRIM28/GSN/TRIM27/SRPK1 6 GO:0002698 negative regulation of immune effector process 7/982 110/18722 0.355575269975787 0.703063157010501 FER/CD46/HLA-B/HLA-A/HLA-E/CD59/GRN 7 GO:0007088 regulation of mitotic nuclear division 7/982 110/18722 0.355575269975787 0.703063157010501 OBSL1/LRP5/BMP7/CENPF/ZWINT/SPDL1/LCMT1 7 GO:0090174 organelle membrane fusion 7/982 110/18722 0.355575269975787 0.703063157010501 SYT7/ANKRD27/RAB13/CLN3/TBC1D4/VAV3/ANXA2 7 GO:0006094 gluconeogenesis 5/982 75/18722 0.35779810341462 0.706654641200552 SLC35B4/SLC25A13/DDB1/SLC25A1/RANBP2 5 GO:0048662 negative regulation of smooth muscle cell proliferation 5/982 75/18722 0.35779810341462 0.706654641200552 GNA12/PPARG/COMT/PPARD/GSTP1 5 GO:2001259 positive regulation of cation channel activity 5/982 75/18722 0.35779810341462 0.706654641200552 TMSB4X/P2RY6/PINK1/ANK3/EHD3 5 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 10/982 164/18722 0.358601038029297 0.707678738421638 GNA12/DAB2/PTK2/CEBPA/MDM2/MAGEF1/PLK2/FBXO22/RAD23B/USP14 10 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 16/982 273/18722 0.360089167211716 0.707678738421638 TENM3/CDH1/DSC3/OBSL1/PCDH11X/DSG2/DSC2/CADM1/CLDN4/FAT1/CLDN19/PLXNB2/PTPRF/CLDN7/ITGB1/BSG 16 GO:0001702 gastrulation with mouth forming second 2/982 24/18722 0.361030123263033 0.707678738421638 LRP5/AMOT 2 GO:0006213 pyrimidine nucleoside metabolic process 2/982 24/18722 0.361030123263033 0.707678738421638 TK1/DTYMK 2 GO:0010226 response to lithium ion 2/982 24/18722 0.361030123263033 0.707678738421638 CDH1/CEBPA 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/982 24/18722 0.361030123263033 0.707678738421638 TMSB4X/PINK1 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/982 24/18722 0.361030123263033 0.707678738421638 TIMP3/SH3D19 2 GO:0051123 RNA polymerase II preinitiation complex assembly 2/982 24/18722 0.361030123263033 0.707678738421638 CAND1/TAF11 2 GO:0051156 glucose 6-phosphate metabolic process 2/982 24/18722 0.361030123263033 0.707678738421638 RPIA/RPE 2 GO:0051570 regulation of histone H3-K9 methylation 2/982 24/18722 0.361030123263033 0.707678738421638 LMNA/DNMT1 2 GO:0061162 establishment of monopolar cell polarity 2/982 24/18722 0.361030123263033 0.707678738421638 FAT1/PRKCI 2 GO:0070841 inclusion body assembly 2/982 24/18722 0.361030123263033 0.707678738421638 HDAC6/TRIM37 2 GO:0071378 cellular response to growth hormone stimulus 2/982 24/18722 0.361030123263033 0.707678738421638 PTK2/LEPROT 2 GO:0071676 negative regulation of mononuclear cell migration 2/982 24/18722 0.361030123263033 0.707678738421638 CD200/WASL 2 GO:0120255 olefinic compound biosynthetic process 2/982 24/18722 0.361030123263033 0.707678738421638 ADM/HSD17B1 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/982 24/18722 0.361030123263033 0.707678738421638 TMSB4X/PINK1 2 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 2/982 24/18722 0.361030123263033 0.707678738421638 CYBA/SLC5A3 2 GO:2000209 regulation of anoikis 2/982 24/18722 0.361030123263033 0.707678738421638 PTK2/ITGB1 2 GO:2000310 regulation of NMDA receptor activity 2/982 24/18722 0.361030123263033 0.707678738421638 APP/PINK1 2 GO:2000679 positive regulation of transcription regulatory region DNA binding 2/982 24/18722 0.361030123263033 0.707678738421638 TRIM6/FOXC1 2 GO:0051591 response to cAMP 6/982 93/18722 0.361938187092371 0.708277162057004 APP/SPARC/BSG/CDO1/NME1/ASS1 6 GO:0090398 cellular senescence 6/982 93/18722 0.361938187092371 0.708277162057004 PAWR/B2M/HRAS/TBX3/CDK6/PLK2 6 GO:0010559 regulation of glycoprotein biosynthetic process 4/982 58/18722 0.362421730354705 0.708277162057004 PAWR/TCF7L2/BACE2/ITM2C 4 GO:0032387 negative regulation of intracellular transport 4/982 58/18722 0.362421730354705 0.708277162057004 FERMT1/LMAN1/NUP153/INSIG1 4 GO:0043525 positive regulation of neuron apoptotic process 4/982 58/18722 0.362421730354705 0.708277162057004 NF1/TFAP2A/NUPR1/GRN 4 GO:0045604 regulation of epidermal cell differentiation 4/982 58/18722 0.362421730354705 0.708277162057004 ESRP1/MAFG/NCOA3/FOXC1 4 GO:0097035 regulation of membrane lipid distribution 4/982 58/18722 0.362421730354705 0.708277162057004 TMEM30B/KCNN4/TRIAP1/ATP10D 4 GO:1902808 positive regulation of cell cycle G1/S phase transition 4/982 58/18722 0.362421730354705 0.708277162057004 ADAMTS1/EGFR/CCND1/MDM2 4 GO:0090288 negative regulation of cellular response to growth factor stimulus 7/982 111/18722 0.364222159597456 0.711529132756678 LRP2/FBN1/SEMA6A/GPC1/PPARG/EPN2/CRIM1 7 GO:0031062 positive regulation of histone methylation 3/982 41/18722 0.365065558588924 0.711577710612791 BRD4/LMNA/DNMT1 3 GO:0044786 cell cycle DNA replication 3/982 41/18722 0.365065558588924 0.711577710612791 MCM2/FEN1/BRCA2 3 GO:0050691 regulation of defense response to virus by host 3/982 41/18722 0.365065558588924 0.711577710612791 EIF2AK4/TRIM6/DHX9 3 GO:0050856 regulation of T cell receptor signaling pathway 3/982 41/18722 0.365065558588924 0.711577710612791 PAWR/KCNN4/BCL10 3 GO:1902622 regulation of neutrophil migration 3/982 41/18722 0.365065558588924 0.711577710612791 JAM3/MPP1/DPP4 3 GO:1905314 semi-lunar valve development 3/982 41/18722 0.365065558588924 0.711577710612791 GJA5/EFNA1/RBPJ 3 GO:0140029 exocytic process 5/982 76/18722 0.368344057917931 0.717699890212899 SYNJ1/SNX4/RAB13/RABEPK/NAPA 5 GO:1903035 negative regulation of response to wounding 6/982 94/18722 0.371406856179015 0.723397371855766 GJA1/UBASH3B/CLDN19/C1QTNF1/PDGFA/ANXA2 6 GO:0060538 skeletal muscle organ development 10/982 166/18722 0.372756359837846 0.725754823782831 DAG1/NR2F2/GPC1/BASP1/FLNB/NUPR1/BIN3/FBXO22/KLF5/ASS1 10 GO:0014074 response to purine-containing compound 9/982 148/18722 0.373288034855855 0.725920112731897 SLC6A4/APP/P2RY6/SPARC/BSG/HSP90B1/CDO1/NME1/ASS1 9 GO:2001056 positive regulation of cysteine-type endopeptidase activity 9/982 148/18722 0.373288034855855 0.725920112731897 PPARG/ASPH/PERP/LGMN/BCL2L13/GSN/BAD/NLRP2/BCL10 9 GO:0007098 centrosome cycle 8/982 130/18722 0.373397941422485 0.725920112731897 SLC16A1/TRIM37/PLK2/BRCA2/CEP152/SDCCAG8/SAC3D1/CEP135 8 GO:0030534 adult behavior 8/982 130/18722 0.373397941422485 0.725920112731897 APP/SHANK2/ATP6V1B1/ABHD12/CHD7/PUM1/MAFG/EPS8 8 GO:0043407 negative regulation of MAP kinase activity 4/982 59/18722 0.374503632694656 0.72741312796575 BMP7/PPARG/NF1/GSTP1 4 GO:0046324 regulation of glucose import 4/982 59/18722 0.374503632694656 0.72741312796575 SORBS1/PRKCI/IRS2/OPN3 4 GO:0045787 positive regulation of cell cycle 18/982 313/18722 0.37800061277105 0.72741312796575 ADAMTS1/PBX1/EGFR/SLC6A4/APP/LRP5/FGFR2/LRP6/BRD4/MTA3/CCND1/RACGAP1/FEN1/TBX3/MDM2/LGMN/NUPR1/BRCA2 18 GO:0043433 negative regulation of DNA-binding transcription factor activity 11/982 185/18722 0.378665201607403 0.72741312796575 CD200/BMP7/EIF2AK4/ID1/TMSB4X/WFS1/FZD6/TRIM37/NUPR1/TCF7L2/NLRP2 11 GO:0006367 transcription initiation from RNA polymerase II promoter 5/982 77/18722 0.378892620410516 0.72741312796575 ZNF451/MED16/CAND1/MED24/TAF11 5 GO:0010827 regulation of glucose transmembrane transport 5/982 77/18722 0.378892620410516 0.72741312796575 SORBS1/PRKCI/YES1/IRS2/OPN3 5 GO:0032418 lysosome localization 5/982 77/18722 0.378892620410516 0.72741312796575 FER/SNX4/TFEB/HDAC6/PDPK1 5 GO:0000413 protein peptidyl-prolyl isomerization 3/982 42/18722 0.379554981511516 0.72741312796575 FKBP9/PPIC/RANBP2 3 GO:0010939 regulation of necrotic cell death 3/982 42/18722 0.379554981511516 0.72741312796575 SPATA2/SLC25A4/NUPR1 3 GO:0021795 cerebral cortex cell migration 3/982 42/18722 0.379554981511516 0.72741312796575 LAMB1/ADGRG1/GLI3 3 GO:0033003 regulation of mast cell activation 3/982 42/18722 0.379554981511516 0.72741312796575 FER/SNX4/PDPK1 3 GO:0045214 sarcomere organization 3/982 42/18722 0.379554981511516 0.72741312796575 CSRP2/ITGB1/KRT8 3 GO:0090317 negative regulation of intracellular protein transport 3/982 42/18722 0.379554981511516 0.72741312796575 FERMT1/LMAN1/INSIG1 3 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 3/982 42/18722 0.379554981511516 0.72741312796575 TEAD1/PPARG/KLF5 3 GO:1904037 positive regulation of epithelial cell apoptotic process 3/982 42/18722 0.379554981511516 0.72741312796575 PRKCI/GSN/BAD 3 GO:2000404 regulation of T cell migration 3/982 42/18722 0.379554981511516 0.72741312796575 CD200/APP/CCL5 3 GO:2001222 regulation of neuron migration 3/982 42/18722 0.379554981511516 0.72741312796575 SEMA6A/ADGRG1/PLXNB2 3 GO:0034767 positive regulation of ion transmembrane transport 10/982 167/18722 0.37985586679875 0.72741312796575 TCAF1/WNK2/TMSB4X/KCNN4/P2RY6/PINK1/ITGB1/ANK3/EHD3/PDPK1 10 GO:0006312 mitotic recombination 2/982 25/18722 0.380167600052912 0.72741312796575 BRCA2/RAD50 2 GO:0010447 response to acidic pH 2/982 25/18722 0.380167600052912 0.72741312796575 SERPINF1/LGMN 2 GO:0010560 positive regulation of glycoprotein biosynthetic process 2/982 25/18722 0.380167600052912 0.72741312796575 PAWR/TCF7L2 2 GO:0010954 positive regulation of protein processing 2/982 25/18722 0.380167600052912 0.72741312796575 MMP14/GSN 2 GO:0032104 regulation of response to extracellular stimulus 2/982 25/18722 0.380167600052912 0.72741312796575 TRIM24/NENF 2 GO:0032107 regulation of response to nutrient levels 2/982 25/18722 0.380167600052912 0.72741312796575 TRIM24/NENF 2 GO:0032400 melanosome localization 2/982 25/18722 0.380167600052912 0.72741312796575 MREG/RAB17 2 GO:0032925 regulation of activin receptor signaling pathway 2/982 25/18722 0.380167600052912 0.72741312796575 ACVR2B/DACT2 2 GO:0035902 response to immobilization stress 2/982 25/18722 0.380167600052912 0.72741312796575 FOXO4/MDM2 2 GO:0046339 diacylglycerol metabolic process 2/982 25/18722 0.380167600052912 0.72741312796575 GPAM/PNPLA2 2 GO:0046949 fatty-acyl-CoA biosynthetic process 2/982 25/18722 0.380167600052912 0.72741312796575 SLC25A1/HSD17B12 2 GO:0048596 embryonic camera-type eye morphogenesis 2/982 25/18722 0.380167600052912 0.72741312796575 BMP7/TFAP2A 2 GO:0051450 myoblast proliferation 2/982 25/18722 0.380167600052912 0.72741312796575 PPARD/MALAT1 2 GO:0051788 response to misfolded protein 2/982 25/18722 0.380167600052912 0.72741312796575 UGGT2/HDAC6 2 GO:0060740 prostate gland epithelium morphogenesis 2/982 25/18722 0.380167600052912 0.72741312796575 FGFR2/BMP7 2 GO:0061339 establishment or maintenance of monopolar cell polarity 2/982 25/18722 0.380167600052912 0.72741312796575 FAT1/PRKCI 2 GO:0071450 cellular response to oxygen radical 2/982 25/18722 0.380167600052912 0.72741312796575 BMP7/PRDX1 2 GO:0071451 cellular response to superoxide 2/982 25/18722 0.380167600052912 0.72741312796575 BMP7/PRDX1 2 GO:0072202 cell differentiation involved in metanephros development 2/982 25/18722 0.380167600052912 0.72741312796575 LGR4/YAP1 2 GO:0072207 metanephric epithelium development 2/982 25/18722 0.380167600052912 0.72741312796575 LGR4/YAP1 2 GO:0098581 detection of external biotic stimulus 2/982 25/18722 0.380167600052912 0.72741312796575 HLA-B/HLA-A 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/982 25/18722 0.380167600052912 0.72741312796575 SORBS1/ESRRA 2 GO:1903792 negative regulation of anion transport 2/982 25/18722 0.380167600052912 0.72741312796575 GABRE/SLC43A2 2 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/982 25/18722 0.380167600052912 0.72741312796575 EGFR/LIN28B 2 GO:1905563 negative regulation of vascular endothelial cell proliferation 2/982 25/18722 0.380167600052912 0.72741312796575 PPARG/FLT1 2 GO:0006942 regulation of striated muscle contraction 6/982 95/18722 0.380883498198785 0.72741312796575 GJA5/DSG2/DSP/DSC2/PKP2/EHD3 6 GO:0036473 cell death in response to oxidative stress 6/982 95/18722 0.380883498198785 0.72741312796575 MET/PAWR/PAGE4/HDAC6/P4HB/PINK1 6 GO:0048709 oligodendrocyte differentiation 6/982 95/18722 0.380883498198785 0.72741312796575 DAG1/PTN/NF1/TNFRSF21/GLI3/GSTP1 6 GO:0019079 viral genome replication 8/982 131/18722 0.381439199124349 0.72741312796575 EIF2AK4/DDB1/TRIM6/HACD3/CCL5/TOP2A/TRIM28/SRPK1 8 GO:0045089 positive regulation of innate immune response 8/982 131/18722 0.381439199124349 0.72741312796575 CADM1/TRIM6/MAP3K7/HLA-E/ZCCHC3/CCL5/PSPC1/DHX9 8 GO:1904950 negative regulation of establishment of protein localization 8/982 131/18722 0.381439199124349 0.72741312796575 CD200/FERMT1/FRMD4A/LMAN1/MAP4K4/INSIG1/LYPLA1/ENY2 8 GO:0043410 positive regulation of MAPK cascade 27/982 480/18722 0.38152190018095 0.72741312796575 EGFR/LRP1/APP/FZD10/FGFR2/TPBG/DVL3/NRP1/WWC1/GCNT2/SEMA4C/MAGED1/TRAF4/IGF1R/FLT1/HRAS/EFNA1/MAP3K7/CD24/FERMT2/P2RY6/C1QTNF1/BCAR3/CCL5/PDGFA/MAP3K13/NENF 27 GO:0002708 positive regulation of lymphocyte mediated immunity 7/982 113/18722 0.38155719289001 0.72741312796575 CADM1/TFRC/B2M/HLA-B/HLA-A/MAP3K7/HLA-E 7 GO:0031623 receptor internalization 7/982 113/18722 0.38155719289001 0.72741312796575 LRP1/TFRC/ADM/CLTC/RAB31/ITGB1/AHI1 7 GO:0044344 cellular response to fibroblast growth factor stimulus 7/982 113/18722 0.38155719289001 0.72741312796575 FGFR2/GPC1/KDM5B/KIF16B/CCL5/EXT2/GCLM 7 GO:1902115 regulation of organelle assembly 11/982 186/18722 0.385412295165836 0.73449416572342 YAP1/LIMK2/PINK1/TRIM37/TBC1D12/NUPR1/PLK2/GSN/SDCCAG8/PHF23/CEP135 11 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 4/982 60/18722 0.38656573238966 0.735617241935231 BRCC3/FOXO4/TOPBP1/USP47 4 GO:0030071 regulation of mitotic metaphase/anaphase transition 4/982 60/18722 0.38656573238966 0.735617241935231 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0051851 modulation by host of symbiont process 4/982 60/18722 0.38656573238966 0.735617241935231 EIF2AK4/TARDBP/CCL5/TAF11 4 GO:1903670 regulation of sprouting angiogenesis 4/982 60/18722 0.38656573238966 0.735617241935231 SEMA6A/EPN2/TJP1/PDPK1 4 GO:0090559 regulation of membrane permeability 5/982 78/18722 0.389436153079793 0.740640295697995 JAM3/TJP2/SLC25A4/BAD/F11R 5 GO:0035264 multicellular organism growth 8/982 132/18722 0.389489327281365 0.740640295697995 ADRB1/APP/GPAM/CHD7/LGMN/AFG3L2/WDR48/CLIC4 8 GO:1901800 positive regulation of proteasomal protein catabolic process 7/982 114/18722 0.390236552656498 0.740950046510191 TMTC3/DAB2/CEBPA/MDM2/NUPR1/PLK2/FBXO22 7 GO:1904892 regulation of receptor signaling pathway via STAT 7/982 114/18722 0.390236552656498 0.740950046510191 PRLR/PPARG/PIGU/IL10RB/CCL5/AKR1B1/LEPROT 7 GO:0030510 regulation of BMP signaling pathway 6/982 96/18722 0.390362486159894 0.740950046510191 LRP2/FBN1/PPARG/CRIM1/FSTL1/RBPJ 6 GO:0034620 cellular response to unfolded protein 6/982 96/18722 0.390362486159894 0.740950046510191 WFS1/CCND1/TMEM33/TM7SF3/CREB3L2/CREB3 6 GO:0042632 cholesterol homeostasis 6/982 96/18722 0.390362486159894 0.740950046510191 LRP5/TSKU/LDLR/CD24/LIMA1/INSIG1 6 GO:0002861 regulation of inflammatory response to antigenic stimulus 3/982 43/18722 0.393971530703724 0.744818957647926 YES1/HLA-E/PLK2 3 GO:0010171 body morphogenesis 3/982 43/18722 0.393971530703724 0.744818957647926 DAG1/DLX5/ZNF281 3 GO:0014014 negative regulation of gliogenesis 3/982 43/18722 0.393971530703724 0.744818957647926 PTN/NF1/LDLR 3 GO:0021983 pituitary gland development 3/982 43/18722 0.393971530703724 0.744818957647926 CDH1/ISL1/RBPJ 3 GO:0036230 granulocyte activation 3/982 43/18722 0.393971530703724 0.744818957647926 CCL5/GRN/ANXA3 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/982 43/18722 0.393971530703724 0.744818957647926 TRIAP1/NUPR1/BRCA2 3 GO:0045981 positive regulation of nucleotide metabolic process 3/982 43/18722 0.393971530703724 0.744818957647926 APP/TMSB4X/PINK1 3 GO:0140353 lipid export from cell 3/982 43/18722 0.393971530703724 0.744818957647926 KDM5B/PTGES/C1QTNF1 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/982 43/18722 0.393971530703724 0.744818957647926 APP/TMSB4X/PINK1 3 GO:1903793 positive regulation of anion transport 3/982 43/18722 0.393971530703724 0.744818957647926 TCAF1/PTGES/ITGB1 3 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 3/982 43/18722 0.393971530703724 0.744818957647926 GNA12/PPARG/GSTP1 3 GO:0043030 regulation of macrophage activation 4/982 61/18722 0.398597283755309 0.745324825627853 CD200/LDLR/CEBPA/GRN 4 GO:0050994 regulation of lipid catabolic process 4/982 61/18722 0.398597283755309 0.745324825627853 LDLR/PNPLA2/IDH1/IRS2 4 GO:0060997 dendritic spine morphogenesis 4/982 61/18722 0.398597283755309 0.745324825627853 PPP1R9A/EFNA1/WASL/HDAC6 4 GO:0060998 regulation of dendritic spine development 4/982 61/18722 0.398597283755309 0.745324825627853 DLG5/PPP1R9A/EFNA1/PLK2 4 GO:2000401 regulation of lymphocyte migration 4/982 61/18722 0.398597283755309 0.745324825627853 CD200/APP/WASL/CCL5 4 GO:0021700 developmental maturation 16/982 280/18722 0.398637458059791 0.745324825627853 PLXNB1/DAG1/APP/FERMT1/PPARG/ANKRD27/EPAS1/RAB38/CEBPA/YTHDF2/MAP3K13/XYLT1/BRCA2/AKR1B1/RERE/RBPJ 16 GO:0071675 regulation of mononuclear cell migration 7/982 115/18722 0.398918063191058 0.745324825627853 CD200/APP/WASL/PTK2/CCL5/LGMN/CREB3 7 GO:0001556 oocyte maturation 2/982 26/18722 0.399057588881683 0.745324825627853 YTHDF2/BRCA2 2 GO:0001573 ganglioside metabolic process 2/982 26/18722 0.399057588881683 0.745324825627853 ITGB8/NEU1 2 GO:0001963 synaptic transmission, dopaminergic 2/982 26/18722 0.399057588881683 0.745324825627853 SLC6A4/PINK1 2 GO:0003416 endochondral bone growth 2/982 26/18722 0.399057588881683 0.745324825627853 FGFR2/TSKU 2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 2/982 26/18722 0.399057588881683 0.745324825627853 TRAM2/SEC63 2 GO:0008535 respiratory chain complex IV assembly 2/982 26/18722 0.399057588881683 0.745324825627853 SCO1/SURF1 2 GO:0021680 cerebellar Purkinje cell layer development 2/982 26/18722 0.399057588881683 0.745324825627853 NAGLU/RERE 2 GO:0021952 central nervous system projection neuron axonogenesis 2/982 26/18722 0.399057588881683 0.745324825627853 NFIB/TSKU 2 GO:0033522 histone H2A ubiquitination 2/982 26/18722 0.399057588881683 0.745324825627853 DDB1/TRIM37 2 GO:0034063 stress granule assembly 2/982 26/18722 0.399057588881683 0.745324825627853 YTHDF2/PUM2 2 GO:0034114 regulation of heterotypic cell-cell adhesion 2/982 26/18722 0.399057588881683 0.745324825627853 BMP7/GCNT2 2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/982 26/18722 0.399057588881683 0.745324825627853 HDAC6/ARMCX3 2 GO:0042634 regulation of hair cycle 2/982 26/18722 0.399057588881683 0.745324825627853 FERMT1/TSKU 2 GO:0045026 plasma membrane fusion 2/982 26/18722 0.399057588881683 0.745324825627853 SPESP1/FOLR1 2 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 2/982 26/18722 0.399057588881683 0.745324825627853 CADM1/HLA-E 2 GO:0047497 mitochondrion transport along microtubule 2/982 26/18722 0.399057588881683 0.745324825627853 HDAC6/ARMCX3 2 GO:0051560 mitochondrial calcium ion homeostasis 2/982 26/18722 0.399057588881683 0.745324825627853 TGM2/AFG3L2 2 GO:0060219 camera-type eye photoreceptor cell differentiation 2/982 26/18722 0.399057588881683 0.745324825627853 NAGLU/PTN 2 GO:0060544 regulation of necroptotic process 2/982 26/18722 0.399057588881683 0.745324825627853 SPATA2/SLC25A4 2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/982 26/18722 0.399057588881683 0.745324825627853 EGFR/LIN28B 2 GO:0070977 bone maturation 2/982 26/18722 0.399057588881683 0.745324825627853 PLXNB1/XYLT1 2 GO:0072273 metanephric nephron morphogenesis 2/982 26/18722 0.399057588881683 0.745324825627853 LGR4/KIF26B 2 GO:1901071 glucosamine-containing compound metabolic process 2/982 26/18722 0.399057588881683 0.745324825627853 EXTL2/MGAT3 2 GO:1902186 regulation of viral release from host cell 2/982 26/18722 0.399057588881683 0.745324825627853 DDB1/TRIM28 2 GO:1904353 regulation of telomere capping 2/982 26/18722 0.399057588881683 0.745324825627853 PKIB/RAD50 2 GO:1904861 excitatory synapse assembly 2/982 26/18722 0.399057588881683 0.745324825627853 VSTM5/PLXNB2 2 GO:0055092 sterol homeostasis 6/982 97/18722 0.399838308802532 0.745324825627853 LRP5/TSKU/LDLR/CD24/LIMA1/INSIG1 6 GO:0006446 regulation of translational initiation 5/982 79/18722 0.399967229050985 0.745324825627853 EIF2AK4/YTHDF2/CCL5/METTL3/DDX1 5 GO:0051279 regulation of release of sequestered calcium ion into cytosol 5/982 79/18722 0.399967229050985 0.745324825627853 UBASH3B/CHD7/P2RY6/CYBA/PDPK1 5 GO:0006874 cellular calcium ion homeostasis 25/982 448/18722 0.403671857404612 0.745324825627853 GJA1/ITGAV/LRP1/MCOLN3/APP/UBASH3B/SWAP70/CHD7/LRP6/TRPV6/ADM/WFS1/ATP2B1/TGM2/ATP13A3/CD24/CLN3/P2RY6/C1QTNF1/CCL5/CYBA/CD52/AFG3L2/HSP90B1/PDPK1 25 GO:0002705 positive regulation of leukocyte mediated immunity 8/982 134/18722 0.405602404240273 0.745324825627853 CADM1/TFRC/B2M/HLA-B/HLA-A/MAP3K7/HLA-E/DDX1 8 GO:0032147 activation of protein kinase activity 8/982 134/18722 0.405602404240273 0.745324825627853 PRLR/EFNA5/TRAF4/MAP3K7/CCL5/PINK1/TPX2/PDPK1 8 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 8/982 134/18722 0.405602404240273 0.745324825627853 GNA12/DAB2/CEBPA/MDM2/PLK2/FBXO22/RAD23B/USP14 8 GO:0009060 aerobic respiration 11/982 189/18722 0.405704338948476 0.745324825627853 ACO1/ADSL/CYC1/PINK1/IDH1/NUPR1/DHTKD1/COX6A1/SUCLA2/FH/SURF1 11 GO:0072503 cellular divalent inorganic cation homeostasis 27/982 486/18722 0.406813644225825 0.745324825627853 GJA1/ITGAV/LRP1/MCOLN3/APP/UBASH3B/SWAP70/CHD7/LRP6/TRPV6/ADM/WFS1/ATP2B1/SLC39A10/TGM2/ATP13A3/CD24/CLN3/P2RY6/C1QTNF1/CCL5/CYBA/CD52/AFG3L2/SLC39A7/HSP90B1/PDPK1 27 GO:0006775 fat-soluble vitamin metabolic process 3/982 44/18722 0.40829887051038 0.745324825627853 LRP2/PPARD/LGMN 3 GO:0008542 visual learning 3/982 44/18722 0.40829887051038 0.745324825627853 APP/NF1/ITGB1 3 GO:0009262 deoxyribonucleotide metabolic process 3/982 44/18722 0.40829887051038 0.745324825627853 DTYMK/ADK/RRM1 3 GO:0031295 T cell costimulation 3/982 44/18722 0.40829887051038 0.745324825627853 YES1/CD24/DPP4 3 GO:0042554 superoxide anion generation 3/982 44/18722 0.40829887051038 0.745324825627853 EGFR/CYBA/GSTP1 3 GO:0051150 regulation of smooth muscle cell differentiation 3/982 44/18722 0.40829887051038 0.745324825627853 FGFR2/FOXO4/DNMT1 3 GO:0070301 cellular response to hydrogen peroxide 6/982 98/18722 0.409305576383817 0.745324825627853 NET1/MET/PAWR/HDAC6/MDM2/PINK1 6 GO:0002573 myeloid leukocyte differentiation 12/982 208/18722 0.409562496483843 0.745324825627853 FBN1/APP/TFRC/UBASH3B/PPARG/ITGB8/CEBPA/ESRRA/CDK6/ANXA2/NME1/RBPJ 12 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 4/982 62/18722 0.410587982862912 0.745324825627853 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0019933 cAMP-mediated signaling 4/982 62/18722 0.410587982862912 0.745324825627853 GNAI1/ADM/ADGRG6/PDE7A 4 GO:0046173 polyol biosynthetic process 4/982 62/18722 0.410587982862912 0.745324825627853 ISYNA1/P2RY6/AKR1B1/SPTLC3 4 GO:0048663 neuron fate commitment 4/982 62/18722 0.410587982862912 0.745324825627853 ISL1/ESRP1/GLI3/RBPJ 4 GO:1902750 negative regulation of cell cycle G2/M phase transition 4/982 62/18722 0.410587982862912 0.745324825627853 BRCC3/FOXO4/TOPBP1/USP47 4 GO:0120254 olefinic compound metabolic process 9/982 153/18722 0.411001992487411 0.745324825627853 ABHD12/RDH10/ADM/HSD17B1/RDH14/CYP2J2/PNPLA2/GSTP1/AKR1B1 9 GO:0099111 microtubule-based transport 11/982 190/18722 0.41247845652324 0.745324825627853 DST/APP/MREG/ARHGAP21/CLN3/HDAC6/ARMCX3/IFT74/NPHP3/FLOT2/KIF4A 11 GO:0016042 lipid catabolic process 18/982 320/18722 0.414419798685589 0.745324825627853 LRP1/SLC27A2/ABHD12/LDLR/ACADS/PLA2G12A/ECI1/PPARD/ACADVL/PNPLA2/IDH1/SLC25A17/FUCA1/DECR2/ECHDC2/IRS2/HADHB/NEU1 18 GO:0002221 pattern recognition receptor signaling pathway 10/982 172/18722 0.415475046157515 0.745324825627853 LGR4/COLEC12/MAP3K7/PUM1/ZCCHC3/CYBA/TSPAN6/PUM2/PDPK1/BCL10 10 GO:0014902 myotube differentiation 7/982 117/18722 0.416270740808958 0.745324825627853 BHLHE41/MMP14/ERVW-1/MYOF/BIN3/FBXO22/KLF5 7 GO:0001820 serotonin secretion 1/982 10/18722 0.416614081009331 0.745324825627853 SLC6A4 1 GO:0002524 hypersensitivity 1/982 10/18722 0.416614081009331 0.745324825627853 HLA-E 1 GO:0003056 regulation of vascular associated smooth muscle contraction 1/982 10/18722 0.416614081009331 0.745324825627853 ATP2B1 1 GO:0005984 disaccharide metabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 GAA 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 PISD 1 GO:0006655 phosphatidylglycerol biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 GPAM 1 GO:0009113 purine nucleobase biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 PPAT 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 DTYMK 1 GO:0009396 folic acid-containing compound biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 ATIC 1 GO:0009750 response to fructose 1/982 10/18722 0.416614081009331 0.745324825627853 KRT18 1 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 1/982 10/18722 0.416614081009331 0.745324825627853 EIF2AK4 1 GO:0014041 regulation of neuron maturation 1/982 10/18722 0.416614081009331 0.745324825627853 MAP3K13 1 GO:0019532 oxalate transport 1/982 10/18722 0.416614081009331 0.745324825627853 SLC26A2 1 GO:0019614 catechol-containing compound catabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 COMT 1 GO:0030638 polyketide metabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 AKR1B1 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 AKR1B1 1 GO:0030953 astral microtubule organization 1/982 10/18722 0.416614081009331 0.745324825627853 LIMK2 1 GO:0031055 chromatin remodeling at centromere 1/982 10/18722 0.416614081009331 0.745324825627853 CENPW 1 GO:0031125 rRNA 3'-end processing 1/982 10/18722 0.416614081009331 0.745324825627853 ERI2 1 GO:0031340 positive regulation of vesicle fusion 1/982 10/18722 0.416614081009331 0.745324825627853 ANXA2 1 GO:0031642 negative regulation of myelination 1/982 10/18722 0.416614081009331 0.745324825627853 TNFRSF21 1 GO:0032070 regulation of deoxyribonuclease activity 1/982 10/18722 0.416614081009331 0.745324825627853 DFFA 1 GO:0032275 luteinizing hormone secretion 1/982 10/18722 0.416614081009331 0.745324825627853 TBX3 1 GO:0032380 regulation of intracellular sterol transport 1/982 10/18722 0.416614081009331 0.745324825627853 ANXA2 1 GO:0032383 regulation of intracellular cholesterol transport 1/982 10/18722 0.416614081009331 0.745324825627853 ANXA2 1 GO:0033314 mitotic DNA replication checkpoint signaling 1/982 10/18722 0.416614081009331 0.745324825627853 TOPBP1 1 GO:0034756 regulation of iron ion transport 1/982 10/18722 0.416614081009331 0.745324825627853 B2M 1 GO:0035520 monoubiquitinated protein deubiquitination 1/982 10/18722 0.416614081009331 0.745324825627853 USP47 1 GO:0035747 natural killer cell chemotaxis 1/982 10/18722 0.416614081009331 0.745324825627853 CCL5 1 GO:0035907 dorsal aorta development 1/982 10/18722 0.416614081009331 0.745324825627853 RBPJ 1 GO:0038007 netrin-activated signaling pathway 1/982 10/18722 0.416614081009331 0.745324825627853 PTK2 1 GO:0042424 catecholamine catabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 COMT 1 GO:0043101 purine-containing compound salvage 1/982 10/18722 0.416614081009331 0.745324825627853 ADK 1 GO:0044598 doxorubicin metabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 AKR1B1 1 GO:0044848 biological phase 1/982 10/18722 0.416614081009331 0.745324825627853 FERMT1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/982 10/18722 0.416614081009331 0.745324825627853 CAND1 1 GO:0048340 paraxial mesoderm morphogenesis 1/982 10/18722 0.416614081009331 0.745324825627853 FOXC1 1 GO:0048672 positive regulation of collateral sprouting 1/982 10/18722 0.416614081009331 0.745324825627853 LRP1 1 GO:0048703 embryonic viscerocranium morphogenesis 1/982 10/18722 0.416614081009331 0.745324825627853 RDH10 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/982 10/18722 0.416614081009331 0.745324825627853 SLC39A10 1 GO:0051660 establishment of centrosome localization 1/982 10/18722 0.416614081009331 0.745324825627853 PARD3 1 GO:0060068 vagina development 1/982 10/18722 0.416614081009331 0.745324825627853 LRP2 1 GO:0060272 embryonic skeletal joint morphogenesis 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:0060513 prostatic bud formation 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:0060525 prostate glandular acinus development 1/982 10/18722 0.416614081009331 0.745324825627853 FGFR2 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/982 10/18722 0.416614081009331 0.745324825627853 SERPINF1 1 GO:0061140 lung secretory cell differentiation 1/982 10/18722 0.416614081009331 0.745324825627853 NFIB 1 GO:0070091 glucagon secretion 1/982 10/18722 0.416614081009331 0.745324825627853 SYT7 1 GO:0070092 regulation of glucagon secretion 1/982 10/18722 0.416614081009331 0.745324825627853 SYT7 1 GO:0070099 regulation of chemokine-mediated signaling pathway 1/982 10/18722 0.416614081009331 0.745324825627853 CCL5 1 GO:0070561 vitamin D receptor signaling pathway 1/982 10/18722 0.416614081009331 0.745324825627853 TRIM24 1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/982 10/18722 0.416614081009331 0.745324825627853 INSIG1 1 GO:0071073 positive regulation of phospholipid biosynthetic process 1/982 10/18722 0.416614081009331 0.745324825627853 RAB38 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/982 10/18722 0.416614081009331 0.745324825627853 GCLM 1 GO:0071421 manganese ion transmembrane transport 1/982 10/18722 0.416614081009331 0.745324825627853 SLC11A2 1 GO:0071600 otic vesicle morphogenesis 1/982 10/18722 0.416614081009331 0.745324825627853 FGFR2 1 GO:0071838 cell proliferation in bone marrow 1/982 10/18722 0.416614081009331 0.745324825627853 FGFR2 1 GO:0072070 loop of Henle development 1/982 10/18722 0.416614081009331 0.745324825627853 IRX2 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:0072178 nephric duct morphogenesis 1/982 10/18722 0.416614081009331 0.745324825627853 AHI1 1 GO:0072203 cell proliferation involved in metanephros development 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:0072378 blood coagulation, fibrin clot formation 1/982 10/18722 0.416614081009331 0.745324825627853 FBLN1 1 GO:0090043 regulation of tubulin deacetylation 1/982 10/18722 0.416614081009331 0.745324825627853 BEX4 1 GO:0090527 actin filament reorganization 1/982 10/18722 0.416614081009331 0.745324825627853 GSN 1 GO:0097084 vascular associated smooth muscle cell development 1/982 10/18722 0.416614081009331 0.745324825627853 ADM 1 GO:0097278 complement-dependent cytotoxicity 1/982 10/18722 0.416614081009331 0.745324825627853 CD59 1 GO:0098917 retrograde trans-synaptic signaling 1/982 10/18722 0.416614081009331 0.745324825627853 DAG1 1 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/982 10/18722 0.416614081009331 0.745324825627853 NSG1 1 GO:1901203 positive regulation of extracellular matrix assembly 1/982 10/18722 0.416614081009331 0.745324825627853 DAG1 1 GO:1901524 regulation of mitophagy 1/982 10/18722 0.416614081009331 0.745324825627853 SLC25A4 1 GO:1901725 regulation of histone deacetylase activity 1/982 10/18722 0.416614081009331 0.745324825627853 PINK1 1 GO:1902855 regulation of non-motile cilium assembly 1/982 10/18722 0.416614081009331 0.745324825627853 CEP135 1 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1/982 10/18722 0.416614081009331 0.745324825627853 EFNA1 1 GO:1903867 extraembryonic membrane development 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:1904526 regulation of microtubule binding 1/982 10/18722 0.416614081009331 0.745324825627853 PPP2CB 1 GO:1905809 negative regulation of synapse organization 1/982 10/18722 0.416614081009331 0.745324825627853 PTN 1 GO:1990253 cellular response to leucine starvation 1/982 10/18722 0.416614081009331 0.745324825627853 EIF2AK4 1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 1/982 10/18722 0.416614081009331 0.745324825627853 PDPK1 1 GO:1990535 neuron projection maintenance 1/982 10/18722 0.416614081009331 0.745324825627853 APP 1 GO:2000121 regulation of removal of superoxide radicals 1/982 10/18722 0.416614081009331 0.745324825627853 BMP7 1 GO:2000425 regulation of apoptotic cell clearance 1/982 10/18722 0.416614081009331 0.745324825627853 TGM2 1 GO:2000434 regulation of protein neddylation 1/982 10/18722 0.416614081009331 0.745324825627853 EPAS1 1 GO:2001223 negative regulation of neuron migration 1/982 10/18722 0.416614081009331 0.745324825627853 ADGRG1 1 GO:2001225 regulation of chloride transport 1/982 10/18722 0.416614081009331 0.745324825627853 GABRE 1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/982 10/18722 0.416614081009331 0.745324825627853 GSN 1 GO:0000027 ribosomal large subunit assembly 2/982 27/18722 0.417673402091682 0.745324825627853 RPF2/RPL10 2 GO:0000737 DNA catabolic process, endonucleolytic 2/982 27/18722 0.417673402091682 0.745324825627853 REXO4/DFFA 2 GO:0007628 adult walking behavior 2/982 27/18722 0.417673402091682 0.745324825627853 ABHD12/CHD7 2 GO:0010561 negative regulation of glycoprotein biosynthetic process 2/982 27/18722 0.417673402091682 0.745324825627853 BACE2/ITM2C 2 GO:0010758 regulation of macrophage chemotaxis 2/982 27/18722 0.417673402091682 0.745324825627853 PTK2/CCL5 2 GO:0031954 positive regulation of protein autophosphorylation 2/982 27/18722 0.417673402091682 0.745324825627853 PDGFA/RAD50 2 GO:0032781 positive regulation of ATPase activity 2/982 27/18722 0.417673402091682 0.745324825627853 TOR1AIP2/NAPA 2 GO:0032786 positive regulation of DNA-templated transcription, elongation 2/982 27/18722 0.417673402091682 0.745324825627853 BRD4/ELL 2 GO:0034453 microtubule anchoring 2/982 27/18722 0.417673402091682 0.745324825627853 DAG1/HOOK3 2 GO:0034505 tooth mineralization 2/982 27/18722 0.417673402091682 0.745324825627853 SLC4A2/TFAP2A 2 GO:0035116 embryonic hindlimb morphogenesis 2/982 27/18722 0.417673402091682 0.745324825627853 CHD7/TBX3 2 GO:0035235 ionotropic glutamate receptor signaling pathway 2/982 27/18722 0.417673402091682 0.745324825627853 APP/CLN3 2 GO:0036037 CD8-positive, alpha-beta T cell activation 2/982 27/18722 0.417673402091682 0.745324825627853 HLA-A/HLA-E 2 GO:0042104 positive regulation of activated T cell proliferation 2/982 27/18722 0.417673402091682 0.745324825627853 GPAM/CD24 2 GO:0045606 positive regulation of epidermal cell differentiation 2/982 27/18722 0.417673402091682 0.745324825627853 NCOA3/FOXC1 2 GO:0060512 prostate gland morphogenesis 2/982 27/18722 0.417673402091682 0.745324825627853 FGFR2/BMP7 2 GO:0061437 renal system vasculature development 2/982 27/18722 0.417673402091682 0.745324825627853 BMP7/NRP1 2 GO:0061440 kidney vasculature development 2/982 27/18722 0.417673402091682 0.745324825627853 BMP7/NRP1 2 GO:1902883 negative regulation of response to oxidative stress 2/982 27/18722 0.417673402091682 0.745324825627853 MET/PINK1 2 GO:0000045 autophagosome assembly 6/982 99/18722 0.418759025945317 0.745731334698113 WIPI2/PINK1/TBC1D12/NUPR1/GABARAPL1/PHF23 6 GO:0002444 myeloid leukocyte mediated immunity 6/982 99/18722 0.418759025945317 0.745731334698113 FER/SNX4/HLA-E/PDPK1/DDX1/ANXA3 6 GO:0006165 nucleoside diphosphate phosphorylation 6/982 99/18722 0.418759025945317 0.745731334698113 APP/NUPR1/NME4/DHTKD1/DTYMK/NME1 6 GO:0031341 regulation of cell killing 6/982 99/18722 0.418759025945317 0.745731334698113 CADM1/B2M/HLA-B/HLA-A/HLA-E/CD59 6 GO:0033209 tumor necrosis factor-mediated signaling pathway 6/982 99/18722 0.418759025945317 0.745731334698113 TMSB4X/SPATA2/KRT18/SPPL2B/GSTP1/KRT8 6 GO:0042100 B cell proliferation 6/982 99/18722 0.418759025945317 0.745731334698113 TFRC/PAWR/TNFRSF21/SLC39A10/VAV3/IRS2 6 GO:0050821 protein stabilization 11/982 191/18722 0.419254259626216 0.746358436249263 PLPP3/SOX4/DVL3/WFS1/EFNA1/USP27X/TBL1X/PINK1/GRN/FLOT2/BAG1 11 GO:0015850 organic hydroxy compound transport 16/982 284/18722 0.420843368604293 0.747197838274244 SLC6A4/LRP1/OSBPL10/KDM5B/SYT7/SLC16A1/PPARG/LRP6/TSKU/LDLR/C1QTNF1/PINK1/RXRA/LIMA1/SLC5A3/ANXA2 16 GO:0001960 negative regulation of cytokine-mediated signaling pathway 5/982 81/18722 0.420963400581209 0.747197838274244 PPARG/YTHDF2/CCL5/GSTP1/METTL3 5 GO:0021954 central nervous system neuron development 5/982 81/18722 0.420963400581209 0.747197838274244 NRP2/FGFR2/NRP1/NFIB/TSKU 5 GO:0003012 muscle system process 25/982 452/18722 0.42130764266932 0.747197838274244 GJA1/DAG1/GJA5/DSG2/DSP/DSC2/PARP2/GAA/IL6ST/ASPH/CAMK2G/CTTN/CALD1/ATP2B1/PPP1R12B/ARHGEF11/SSPN/MYOF/TBX3/CYBA/LMNA/PKP2/GSN/SMAD5/EHD3 25 GO:0050866 negative regulation of cell activation 12/982 210/18722 0.422498173944443 0.747197838274244 CD200/SOCS6/PAWR/UBASH3B/FER/DLG5/TNFRSF21/LDLR/GLI3/C1QTNF1/PDGFA/GRN 12 GO:0035384 thioester biosynthetic process 3/982 45/18722 0.422521742642188 0.747197838274244 ACSS1/SLC25A1/HSD17B12 3 GO:0045910 negative regulation of DNA recombination 3/982 45/18722 0.422521742642188 0.747197838274244 POLQ/RMI2/MAGEF1 3 GO:0048546 digestive tract morphogenesis 3/982 45/18722 0.422521742642188 0.747197838274244 FGFR2/GLI3/AHI1 3 GO:0071616 acyl-CoA biosynthetic process 3/982 45/18722 0.422521742642188 0.747197838274244 ACSS1/SLC25A1/HSD17B12 3 GO:1901985 positive regulation of protein acetylation 3/982 45/18722 0.422521742642188 0.747197838274244 ISL1/SOX4/RPS6KA4 3 GO:0001947 heart looping 4/982 63/18722 0.422527971945405 0.747197838274244 FOLR1/TBX3/NPHP3/AHI1 4 GO:0002704 negative regulation of leukocyte mediated immunity 4/982 63/18722 0.422527971945405 0.747197838274244 CD46/HLA-B/HLA-A/HLA-E 4 GO:0030239 myofibril assembly 4/982 63/18722 0.422527971945405 0.747197838274244 OBSL1/CSRP2/ITGB1/KRT8 4 GO:0050854 regulation of antigen receptor-mediated signaling pathway 4/982 63/18722 0.422527971945405 0.747197838274244 PAWR/SLC39A10/KCNN4/BCL10 4 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 4/982 63/18722 0.422527971945405 0.747197838274244 CENPF/ZWINT/SPDL1/LCMT1 4 GO:2000242 negative regulation of reproductive process 4/982 63/18722 0.422527971945405 0.747197838274244 GJA1/BMP7/SERPINF1/PRDX4 4 GO:2000756 regulation of peptidyl-lysine acetylation 4/982 63/18722 0.422527971945405 0.747197838274244 ISL1/SOX4/ZNF451/RPS6KA4 4 GO:0042391 regulation of membrane potential 24/982 434/18722 0.424452603013717 0.747197838274244 GJA1/ADRB1/APP/GJA5/DSG2/GABRE/DSP/DSC2/PTN/CLDN19/SLC25A36/PPP1R9A/GNA11/SLC29A1/KCNN4/USP53/IFI6/CLN3/PINK1/PKP2/ANK3/GCLM/EHD3/BAD 24 GO:0006413 translational initiation 7/982 118/18722 0.424933706857034 0.747197838274244 EIF2AK4/YTHDF2/CCL5/ABCE1/EIF1AY/METTL3/DDX1 7 GO:0051147 regulation of muscle cell differentiation 9/982 155/18722 0.426100942349977 0.747197838274244 BHLHE41/FGFR2/PARP2/MMP14/FOXO4/MORF4L2/MDM2/DNMT1/FBXO22 9 GO:0034754 cellular hormone metabolic process 8/982 137/18722 0.429753636552138 0.747197838274244 RDH10/ADM/HSD17B1/RDH14/COMT/PNPLA2/AKR1B1/HSD17B12 8 GO:0045471 response to ethanol 8/982 137/18722 0.429753636552138 0.747197838274244 FGFR2/ALAD/CCND1/EPS8/SPARC/GSTP1/CDO1/BAD 8 GO:0001910 regulation of leukocyte mediated cytotoxicity 5/982 82/18722 0.431414757427703 0.747197838274244 CADM1/B2M/HLA-B/HLA-A/HLA-E 5 GO:0046889 positive regulation of lipid biosynthetic process 5/982 82/18722 0.431414757427703 0.747197838274244 SORBS1/RDH10/ADM/LDLR/RAB38 5 GO:0031398 positive regulation of protein ubiquitination 7/982 119/18722 0.433582428982105 0.747197838274244 SKP2/WFS1/PINK1/PTTG1IP/HUWE1/PHF23/BCL10 7 GO:0009267 cellular response to starvation 9/982 156/18722 0.433642307209165 0.747197838274244 CTSV/EIF2AK4/SLC2A1/WIPI2/TFEB/COMT/GABARAPL1/SLC38A2/RRAGA 9 GO:0055002 striated muscle cell development 4/982 64/18722 0.43440784194465 0.747197838274244 OBSL1/CSRP2/ITGB1/KRT8 4 GO:0098930 axonal transport 4/982 64/18722 0.43440784194465 0.747197838274244 DST/HDAC6/ARMCX3/KIF4A 4 GO:1900076 regulation of cellular response to insulin stimulus 4/982 64/18722 0.43440784194465 0.747197838274244 KANK1/SORBS1/ATP2B1/ESRRA 4 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/982 64/18722 0.43440784194465 0.747197838274244 ALAD/EFNA1/USP14/USP25 4 GO:0000303 response to superoxide 2/982 28/18722 0.435991826469669 0.747197838274244 BMP7/PRDX1 2 GO:0000470 maturation of LSU-rRNA 2/982 28/18722 0.435991826469669 0.747197838274244 MAK16/RPF2 2 GO:0002675 positive regulation of acute inflammatory response 2/982 28/18722 0.435991826469669 0.747197838274244 IL6ST/HLA-E 2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 2/982 28/18722 0.435991826469669 0.747197838274244 UGGT2/HDAC6 2 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 2/982 28/18722 0.435991826469669 0.747197838274244 LRP1/PARD3 2 GO:0009312 oligosaccharide biosynthetic process 2/982 28/18722 0.435991826469669 0.747197838274244 FUT8/ST3GAL6 2 GO:0010460 positive regulation of heart rate 2/982 28/18722 0.435991826469669 0.747197838274244 ADRB1/ADM 2 GO:0010575 positive regulation of vascular endothelial growth factor production 2/982 28/18722 0.435991826469669 0.747197838274244 ISL1/IL6ST 2 GO:0044331 cell-cell adhesion mediated by cadherin 2/982 28/18722 0.435991826469669 0.747197838274244 FER/TJP1 2 GO:0045671 negative regulation of osteoclast differentiation 2/982 28/18722 0.435991826469669 0.747197838274244 FBN1/UBASH3B 2 GO:0045686 negative regulation of glial cell differentiation 2/982 28/18722 0.435991826469669 0.747197838274244 NF1/LDLR 2 GO:0050996 positive regulation of lipid catabolic process 2/982 28/18722 0.435991826469669 0.747197838274244 PNPLA2/IRS2 2 GO:0060765 regulation of androgen receptor signaling pathway 2/982 28/18722 0.435991826469669 0.747197838274244 DAB2/HDAC6 2 GO:0061082 myeloid leukocyte cytokine production 2/982 28/18722 0.435991826469669 0.747197838274244 DDX1/BCL10 2 GO:0070076 histone lysine demethylation 2/982 28/18722 0.435991826469669 0.747197838274244 KDM5B/UTY 2 GO:0080111 DNA demethylation 2/982 28/18722 0.435991826469669 0.747197838274244 TET2/TRIM28 2 GO:0090200 positive regulation of release of cytochrome c from mitochondria 2/982 28/18722 0.435991826469669 0.747197838274244 PINK1/BAD 2 GO:0090344 negative regulation of cell aging 2/982 28/18722 0.435991826469669 0.747197838274244 CDK6/PLK2 2 GO:0090659 walking behavior 2/982 28/18722 0.435991826469669 0.747197838274244 ABHD12/CHD7 2 GO:1903020 positive regulation of glycoprotein metabolic process 2/982 28/18722 0.435991826469669 0.747197838274244 PAWR/TCF7L2 2 GO:1903671 negative regulation of sprouting angiogenesis 2/982 28/18722 0.435991826469669 0.747197838274244 SEMA6A/EPN2 2 GO:1903672 positive regulation of sprouting angiogenesis 2/982 28/18722 0.435991826469669 0.747197838274244 TJP1/PDPK1 2 GO:0006383 transcription by RNA polymerase III 3/982 46/18722 0.436625941930323 0.747197838274244 CEBPA/ELL/PRDX5 3 GO:0006984 ER-nucleus signaling pathway 3/982 46/18722 0.436625941930323 0.747197838274244 WFS1/TMEM33/INSIG1 3 GO:0007019 microtubule depolymerization 3/982 46/18722 0.436625941930323 0.747197838274244 HDAC6/CAMSAP2/TPX2 3 GO:0010830 regulation of myotube differentiation 3/982 46/18722 0.436625941930323 0.747197838274244 BHLHE41/MMP14/FBXO22 3 GO:0031294 lymphocyte costimulation 3/982 46/18722 0.436625941930323 0.747197838274244 YES1/CD24/DPP4 3 GO:0043300 regulation of leukocyte degranulation 3/982 46/18722 0.436625941930323 0.747197838274244 FER/SNX4/PDPK1 3 GO:0043462 regulation of ATPase activity 3/982 46/18722 0.436625941930323 0.747197838274244 TOR1AIP2/VMA21/NAPA 3 GO:0044818 mitotic G2/M transition checkpoint 3/982 46/18722 0.436625941930323 0.747197838274244 BRCC3/FOXO4/TOPBP1 3 GO:0046839 phospholipid dephosphorylation 3/982 46/18722 0.436625941930323 0.747197838274244 PLPP3/SYNJ1/INPPL1 3 GO:0061028 establishment of endothelial barrier 3/982 46/18722 0.436625941930323 0.747197838274244 TJP1/TJP2/F11R 3 GO:0061462 protein localization to lysosome 3/982 46/18722 0.436625941930323 0.747197838274244 SH3BP4/RNF128/SCARB2 3 GO:0090329 regulation of DNA-dependent DNA replication 3/982 46/18722 0.436625941930323 0.747197838274244 CHTF8/WRNIP1/BRCA2 3 GO:0022900 electron transport chain 10/982 175/18722 0.43685889395452 0.747197838274244 GLDC/SLC25A13/ASPH/DEGS1/CYC1/CYBA/PINK1/COX6A1/AKR1B1/SURF1 10 GO:0046939 nucleotide phosphorylation 6/982 101/18722 0.4376040811798 0.747197838274244 APP/NUPR1/NME4/DHTKD1/DTYMK/NME1 6 GO:0051963 regulation of synapse assembly 6/982 101/18722 0.4376040811798 0.747197838274244 APP/VSTM5/TPBG/DLG5/PPP1R9A/RAB17 6 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 8/982 138/18722 0.437786070990789 0.747197838274244 SKP2/WFS1/PINK1/WDR48/PTTG1IP/HUWE1/PHF23/BCL10 8 GO:0051251 positive regulation of lymphocyte activation 20/982 362/18722 0.438138230664334 0.747197838274244 SOX4/TFRC/MMP14/IL6ST/GPAM/B2M/CD46/HLA-A/GLI3/SLC39A10/YES1/CD24/HLA-E/CCL5/VAV3/IRS2/DPP4/FLOT2/BAD/BCL10 20 GO:1902600 proton transmembrane transport 9/982 157/18722 0.441174724861223 0.747197838274244 ATP6V1B1/TMSB4X/SLC25A4/CYC1/SLC11A2/ATP6V1H/COX6A1/ATP6V1C2/SURF1 9 GO:2000377 regulation of reactive oxygen species metabolic process 9/982 157/18722 0.441174724861223 0.747197838274244 EGFR/BMP7/TFAP2A/PAGE4/HDAC6/CYBA/PINK1/GSTP1/SLC5A3 9 GO:0061053 somite development 5/982 83/18722 0.44182618990702 0.747197838274244 COBL/LRP6/AXIN2/FOXC1/RBPJ 5 GO:0071774 response to fibroblast growth factor 7/982 120/18722 0.442213019614251 0.747197838274244 FGFR2/GPC1/KDM5B/KIF16B/CCL5/EXT2/GCLM 7 GO:0097193 intrinsic apoptotic signaling pathway 16/982 288/18722 0.443089318649201 0.747197838274244 SIAH1/PERP/WFS1/HRAS/IFI6/CD24/P4HB/MDM2/TRIAP1/PINK1/NUPR1/BRCA2/USP47/PTTG1IP/CREB3/BAD 16 GO:0010965 regulation of mitotic sister chromatid separation 4/982 65/18722 0.446218633343889 0.747197838274244 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0038034 signal transduction in absence of ligand 4/982 65/18722 0.446218633343889 0.747197838274244 ITGAV/ERBB3/IFI6/BAD 4 GO:0044784 metaphase/anaphase transition of cell cycle 4/982 65/18722 0.446218633343889 0.747197838274244 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0045453 bone resorption 4/982 65/18722 0.446218633343889 0.747197838274244 EGFR/TFRC/UBASH3B/NF1 4 GO:0071677 positive regulation of mononuclear cell migration 4/982 65/18722 0.446218633343889 0.747197838274244 APP/CCL5/LGMN/CREB3 4 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 4/982 65/18722 0.446218633343889 0.747197838274244 ITGAV/ERBB3/IFI6/BAD 4 GO:1990542 mitochondrial transmembrane transport 6/982 102/18722 0.44698583527379 0.747197838274244 SLC25A13/SLC25A36/SLC25A4/SLC25A1/AFG3L2/TST 6 GO:0001660 fever generation 1/982 11/18722 0.447229994457858 0.747197838274244 PTGES 1 GO:0001787 natural killer cell proliferation 1/982 11/18722 0.447229994457858 0.747197838274244 HLA-E 1 GO:0002357 defense response to tumor cell 1/982 11/18722 0.447229994457858 0.747197838274244 RBMS3 1 GO:0002732 positive regulation of dendritic cell cytokine production 1/982 11/18722 0.447229994457858 0.747197838274244 DDX1 1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 1/982 11/18722 0.447229994457858 0.747197838274244 CD46 1 GO:0003157 endocardium development 1/982 11/18722 0.447229994457858 0.747197838274244 RBPJ 1 GO:0003263 cardioblast proliferation 1/982 11/18722 0.447229994457858 0.747197838274244 ISL1 1 GO:0003264 regulation of cardioblast proliferation 1/982 11/18722 0.447229994457858 0.747197838274244 ISL1 1 GO:0006002 fructose 6-phosphate metabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 GFPT1 1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1/982 11/18722 0.447229994457858 0.747197838274244 CYC1 1 GO:0008611 ether lipid biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 CHPT1 1 GO:0010269 response to selenium ion 1/982 11/18722 0.447229994457858 0.747197838274244 ALAD 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/982 11/18722 0.447229994457858 0.747197838274244 BAD 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/982 11/18722 0.447229994457858 0.747197838274244 ANXA2 1 GO:0014854 response to inactivity 1/982 11/18722 0.447229994457858 0.747197838274244 DAG1 1 GO:0018026 peptidyl-lysine monomethylation 1/982 11/18722 0.447229994457858 0.747197838274244 KMT5A 1 GO:0018342 protein prenylation 1/982 11/18722 0.447229994457858 0.747197838274244 CHML 1 GO:0021860 pyramidal neuron development 1/982 11/18722 0.447229994457858 0.747197838274244 FGFR2 1 GO:0021889 olfactory bulb interneuron differentiation 1/982 11/18722 0.447229994457858 0.747197838274244 DLX5 1 GO:0030432 peristalsis 1/982 11/18722 0.447229994457858 0.747197838274244 TBX3 1 GO:0030656 regulation of vitamin metabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 RDH10 1 GO:0032000 positive regulation of fatty acid beta-oxidation 1/982 11/18722 0.447229994457858 0.747197838274244 IRS2 1 GO:0032276 regulation of gonadotropin secretion 1/982 11/18722 0.447229994457858 0.747197838274244 GJA1 1 GO:0032308 positive regulation of prostaglandin secretion 1/982 11/18722 0.447229994457858 0.747197838274244 PTGES 1 GO:0032377 regulation of intracellular lipid transport 1/982 11/18722 0.447229994457858 0.747197838274244 ANXA2 1 GO:0032610 interleukin-1 alpha production 1/982 11/18722 0.447229994457858 0.747197838274244 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/982 11/18722 0.447229994457858 0.747197838274244 ISL1 1 GO:0032957 inositol trisphosphate metabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 P2RY6 1 GO:0033327 Leydig cell differentiation 1/982 11/18722 0.447229994457858 0.747197838274244 CCND1 1 GO:0033483 gas homeostasis 1/982 11/18722 0.447229994457858 0.747197838274244 GSTP1 1 GO:0033860 regulation of NAD(P)H oxidase activity 1/982 11/18722 0.447229994457858 0.747197838274244 CYBA 1 GO:0034350 regulation of glial cell apoptotic process 1/982 11/18722 0.447229994457858 0.747197838274244 PRKCI 1 GO:0034454 microtubule anchoring at centrosome 1/982 11/18722 0.447229994457858 0.747197838274244 HOOK3 1 GO:0034770 histone H4-K20 methylation 1/982 11/18722 0.447229994457858 0.747197838274244 KMT5A 1 GO:0035404 histone-serine phosphorylation 1/982 11/18722 0.447229994457858 0.747197838274244 RPS6KA4 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/982 11/18722 0.447229994457858 0.747197838274244 EIF2AK4 1 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/982 11/18722 0.447229994457858 0.747197838274244 TSPAN6 1 GO:0042135 neurotransmitter catabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 COMT 1 GO:0042451 purine nucleoside biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 ADK 1 GO:0042455 ribonucleoside biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 ADK 1 GO:0043312 neutrophil degranulation 1/982 11/18722 0.447229994457858 0.747197838274244 ANXA3 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/982 11/18722 0.447229994457858 0.747197838274244 EPAS1 1 GO:0045060 negative thymic T cell selection 1/982 11/18722 0.447229994457858 0.747197838274244 GLI3 1 GO:0046129 purine ribonucleoside biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 ADK 1 GO:0046349 amino sugar biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 GFPT1 1 GO:0046504 glycerol ether biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 CHPT1 1 GO:0046598 positive regulation of viral entry into host cell 1/982 11/18722 0.447229994457858 0.747197838274244 P4HB 1 GO:0046643 regulation of gamma-delta T cell activation 1/982 11/18722 0.447229994457858 0.747197838274244 SOX4 1 GO:0046929 negative regulation of neurotransmitter secretion 1/982 11/18722 0.447229994457858 0.747197838274244 PPP1R9A 1 GO:0046940 nucleoside monophosphate phosphorylation 1/982 11/18722 0.447229994457858 0.747197838274244 DTYMK 1 GO:0048102 autophagic cell death 1/982 11/18722 0.447229994457858 0.747197838274244 CTSV 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/982 11/18722 0.447229994457858 0.747197838274244 NF1 1 GO:0048853 forebrain morphogenesis 1/982 11/18722 0.447229994457858 0.747197838274244 NF1 1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1/982 11/18722 0.447229994457858 0.747197838274244 CYFIP1 1 GO:0051561 positive regulation of mitochondrial calcium ion concentration 1/982 11/18722 0.447229994457858 0.747197838274244 TGM2 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/982 11/18722 0.447229994457858 0.747197838274244 DNMT1 1 GO:0051574 positive regulation of histone H3-K9 methylation 1/982 11/18722 0.447229994457858 0.747197838274244 LMNA 1 GO:0051610 serotonin uptake 1/982 11/18722 0.447229994457858 0.747197838274244 SLC6A4 1 GO:0052646 alditol phosphate metabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 GPAM 1 GO:0055015 ventricular cardiac muscle cell development 1/982 11/18722 0.447229994457858 0.747197838274244 LMNA 1 GO:0060312 regulation of blood vessel remodeling 1/982 11/18722 0.447229994457858 0.747197838274244 CST3 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/982 11/18722 0.447229994457858 0.747197838274244 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/982 11/18722 0.447229994457858 0.747197838274244 GLI3 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/982 11/18722 0.447229994457858 0.747197838274244 SERPINF1 1 GO:0060900 embryonic camera-type eye formation 1/982 11/18722 0.447229994457858 0.747197838274244 TFAP2A 1 GO:0061029 eyelid development in camera-type eye 1/982 11/18722 0.447229994457858 0.747197838274244 TFAP2A 1 GO:0061303 cornea development in camera-type eye 1/982 11/18722 0.447229994457858 0.747197838274244 LIMK2 1 GO:0061635 regulation of protein complex stability 1/982 11/18722 0.447229994457858 0.747197838274244 ECSIT 1 GO:0070243 regulation of thymocyte apoptotic process 1/982 11/18722 0.447229994457858 0.747197838274244 EFNA1 1 GO:0070417 cellular response to cold 1/982 11/18722 0.447229994457858 0.747197838274244 EIF2AK4 1 GO:0070601 centromeric sister chromatid cohesion 1/982 11/18722 0.447229994457858 0.747197838274244 AXIN2 1 GO:0070933 histone H4 deacetylation 1/982 11/18722 0.447229994457858 0.747197838274244 RCOR1 1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 1/982 11/18722 0.447229994457858 0.747197838274244 PTN 1 GO:0071377 cellular response to glucagon stimulus 1/982 11/18722 0.447229994457858 0.747197838274244 ASS1 1 GO:0071888 macrophage apoptotic process 1/982 11/18722 0.447229994457858 0.747197838274244 CTSL 1 GO:0072110 glomerular mesangial cell proliferation 1/982 11/18722 0.447229994457858 0.747197838274244 BMP7 1 GO:0072173 metanephric tubule morphogenesis 1/982 11/18722 0.447229994457858 0.747197838274244 LGR4 1 GO:0072497 mesenchymal stem cell differentiation 1/982 11/18722 0.447229994457858 0.747197838274244 KRT18 1 GO:0072697 protein localization to cell cortex 1/982 11/18722 0.447229994457858 0.747197838274244 GNAI1 1 GO:0075294 positive regulation by symbiont of entry into host 1/982 11/18722 0.447229994457858 0.747197838274244 P4HB 1 GO:0075733 intracellular transport of virus 1/982 11/18722 0.447229994457858 0.747197838274244 NUP153 1 GO:0086016 AV node cell action potential 1/982 11/18722 0.447229994457858 0.747197838274244 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/982 11/18722 0.447229994457858 0.747197838274244 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/982 11/18722 0.447229994457858 0.747197838274244 GJA5 1 GO:0097354 prenylation 1/982 11/18722 0.447229994457858 0.747197838274244 CHML 1 GO:0097384 cellular lipid biosynthetic process 1/982 11/18722 0.447229994457858 0.747197838274244 CHPT1 1 GO:0097494 regulation of vesicle size 1/982 11/18722 0.447229994457858 0.747197838274244 ALS2 1 GO:0097499 protein localization to non-motile cilium 1/982 11/18722 0.447229994457858 0.747197838274244 ZDHHC3 1 GO:0098792 xenophagy 1/982 11/18722 0.447229994457858 0.747197838274244 WIPI2 1 GO:0098935 dendritic transport 1/982 11/18722 0.447229994457858 0.747197838274244 FLOT2 1 GO:0099022 vesicle tethering 1/982 11/18722 0.447229994457858 0.747197838274244 TRIP11 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/982 11/18722 0.447229994457858 0.747197838274244 LMNA 1 GO:1902188 positive regulation of viral release from host cell 1/982 11/18722 0.447229994457858 0.747197838274244 DDB1 1 GO:1902510 regulation of apoptotic DNA fragmentation 1/982 11/18722 0.447229994457858 0.747197838274244 DFFA 1 GO:1902667 regulation of axon guidance 1/982 11/18722 0.447229994457858 0.747197838274244 NRP1 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/982 11/18722 0.447229994457858 0.747197838274244 TMEM33 1 GO:1904181 positive regulation of membrane depolarization 1/982 11/18722 0.447229994457858 0.747197838274244 ANK3 1 GO:1904321 response to forskolin 1/982 11/18722 0.447229994457858 0.747197838274244 GNAI1 1 GO:1904322 cellular response to forskolin 1/982 11/18722 0.447229994457858 0.747197838274244 GNAI1 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/982 11/18722 0.447229994457858 0.747197838274244 CD200 1 GO:1905050 positive regulation of metallopeptidase activity 1/982 11/18722 0.447229994457858 0.747197838274244 CLDN4 1 GO:1905522 negative regulation of macrophage migration 1/982 11/18722 0.447229994457858 0.747197838274244 CD200 1 GO:1905668 positive regulation of protein localization to endosome 1/982 11/18722 0.447229994457858 0.747197838274244 MGAT3 1 GO:1990773 matrix metallopeptidase secretion 1/982 11/18722 0.447229994457858 0.747197838274244 CD200 1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/982 11/18722 0.447229994457858 0.747197838274244 TJP1 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/982 11/18722 0.447229994457858 0.747197838274244 LRP1 1 GO:2000392 regulation of lamellipodium morphogenesis 1/982 11/18722 0.447229994457858 0.747197838274244 KANK1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/982 11/18722 0.447229994457858 0.747197838274244 PKIB 1 GO:2000615 regulation of histone H3-K9 acetylation 1/982 11/18722 0.447229994457858 0.747197838274244 ZNF451 1 GO:2000644 regulation of receptor catabolic process 1/982 11/18722 0.447229994457858 0.747197838274244 ANXA2 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/982 11/18722 0.447229994457858 0.747197838274244 BMP7 1 GO:0001774 microglial cell activation 3/982 47/18722 0.450598289377821 0.748901523085938 APP/LDLR/GRN 3 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 3/982 47/18722 0.450598289377821 0.748901523085938 SPATA2/SPPL2B/GSTP1 3 GO:0016574 histone ubiquitination 3/982 47/18722 0.450598289377821 0.748901523085938 DDB1/TRIM37/HUWE1 3 GO:0032008 positive regulation of TOR signaling 3/982 47/18722 0.450598289377821 0.748901523085938 SLC38A9/RICTOR/RRAGA 3 GO:0045332 phospholipid translocation 3/982 47/18722 0.450598289377821 0.748901523085938 TMEM30B/KCNN4/ATP10D 3 GO:0048512 circadian behavior 3/982 47/18722 0.450598289377821 0.748901523085938 ADRB1/NAGLU/ZFHX3 3 GO:0097028 dendritic cell differentiation 3/982 47/18722 0.450598289377821 0.748901523085938 ITGB8/HLA-B/RBPJ 3 GO:0097300 programmed necrotic cell death 3/982 47/18722 0.450598289377821 0.748901523085938 SPATA2/SLC25A4/NUPR1 3 GO:0101023 vascular endothelial cell proliferation 3/982 47/18722 0.450598289377821 0.748901523085938 PPARG/FLT1/PDPK1 3 GO:1905562 regulation of vascular endothelial cell proliferation 3/982 47/18722 0.450598289377821 0.748901523085938 PPARG/FLT1/PDPK1 3 GO:0043500 muscle adaptation 7/982 121/18722 0.450821682014606 0.748901523085938 DAG1/PARP2/IL6ST/CAMK2G/CYBA/LMNA/GSN 7 GO:0090257 regulation of muscle system process 14/982 252/18722 0.45163971592841 0.748901523085938 DAG1/GJA5/DSG2/DSP/DSC2/PARP2/IL6ST/CAMK2G/CTTN/ATP2B1/PPP1R12B/LMNA/PKP2/EHD3 14 GO:0002088 lens development in camera-type eye 5/982 84/18722 0.4521914155346 0.748901523085938 KDM5B/NHS/FAT1/BCAR3/VIM 5 GO:0007292 female gamete generation 8/982 140/18722 0.453805065677937 0.748901523085938 ADAMTS1/LGR5/PTN/ASPM/YTHDF2/TOP2A/BRCA2/METTL3 8 GO:0001773 myeloid dendritic cell activation 2/982 29/18722 0.453992832821652 0.748901523085938 ITGB8/RBPJ 2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/982 29/18722 0.453992832821652 0.748901523085938 YES1/PLK2 2 GO:0003209 cardiac atrium morphogenesis 2/982 29/18722 0.453992832821652 0.748901523085938 ISL1/SOX4 2 GO:0009218 pyrimidine ribonucleotide metabolic process 2/982 29/18722 0.453992832821652 0.748901523085938 NME4/NME1 2 GO:0010390 histone monoubiquitination 2/982 29/18722 0.453992832821652 0.748901523085938 DDB1/TRIM37 2 GO:0010592 positive regulation of lamellipodium assembly 2/982 29/18722 0.453992832821652 0.748901523085938 CYFIP1/NCKAP1 2 GO:0010955 negative regulation of protein processing 2/982 29/18722 0.453992832821652 0.748901523085938 MDM2/GLG1 2 GO:0019082 viral protein processing 2/982 29/18722 0.453992832821652 0.748901523085938 MOGS/FUT8 2 GO:0021772 olfactory bulb development 2/982 29/18722 0.453992832821652 0.748901523085938 CHD7/DLX5 2 GO:0030970 retrograde protein transport, ER to cytosol 2/982 29/18722 0.453992832821652 0.748901523085938 HSP90B1/FAF2 2 GO:0034067 protein localization to Golgi apparatus 2/982 29/18722 0.453992832821652 0.748901523085938 OBSL1/ARL5B 2 GO:0034311 diol metabolic process 2/982 29/18722 0.453992832821652 0.748901523085938 PLPP3/SPTLC3 2 GO:0035066 positive regulation of histone acetylation 2/982 29/18722 0.453992832821652 0.748901523085938 ISL1/RPS6KA4 2 GO:0040018 positive regulation of multicellular organism growth 2/982 29/18722 0.453992832821652 0.748901523085938 GPAM/CHD7 2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2/982 29/18722 0.453992832821652 0.748901523085938 EGFR/CCND1 2 GO:0048265 response to pain 2/982 29/18722 0.453992832821652 0.748901523085938 VWA1/COMT 2 GO:0051654 establishment of mitochondrion localization 2/982 29/18722 0.453992832821652 0.748901523085938 HDAC6/ARMCX3 2 GO:0070198 protein localization to chromosome, telomeric region 2/982 29/18722 0.453992832821652 0.748901523085938 ATR/BRCA2 2 GO:0090114 COPII-coated vesicle budding 2/982 29/18722 0.453992832821652 0.748901523085938 TFG/INSIG1 2 GO:0098868 bone growth 2/982 29/18722 0.453992832821652 0.748901523085938 FGFR2/TSKU 2 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/982 29/18722 0.453992832821652 0.748901523085938 P4HB/PINK1 2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/982 29/18722 0.453992832821652 0.748901523085938 TRIAP1/USP47 2 GO:1903318 negative regulation of protein maturation 2/982 29/18722 0.453992832821652 0.748901523085938 MDM2/GLG1 2 GO:1903513 endoplasmic reticulum to cytosol transport 2/982 29/18722 0.453992832821652 0.748901523085938 HSP90B1/FAF2 2 GO:1903902 positive regulation of viral life cycle 2/982 29/18722 0.453992832821652 0.748901523085938 DDB1/P4HB 2 GO:2000406 positive regulation of T cell migration 2/982 29/18722 0.453992832821652 0.748901523085938 APP/CCL5 2 GO:0071103 DNA conformation change 16/982 290/18722 0.454205388069693 0.749015271631843 CHD7/POLQ/MCM2/SMC2/CHTF8/WRNIP1/NAV2/RAD54L2/TOP2A/DHX9/CENPW/TOP1/KMT5A/SRPK1/RAD50/DDX1 16 GO:0009135 purine nucleoside diphosphate metabolic process 6/982 103/18722 0.456334075311607 0.7518125511135 APP/TJP2/MPP1/NUPR1/DHTKD1/BAD 6 GO:0009179 purine ribonucleoside diphosphate metabolic process 6/982 103/18722 0.456334075311607 0.7518125511135 APP/TJP2/MPP1/NUPR1/DHTKD1/BAD 6 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 6/982 103/18722 0.456334075311607 0.7518125511135 PRLR/PIGU/IL10RB/CCL5/AKR1B1/LEPROT 6 GO:0006936 muscle contraction 19/982 347/18722 0.457156901237409 0.7525209705251 GJA1/GJA5/DSG2/DSP/DSC2/GAA/ASPH/CTTN/CALD1/ATP2B1/PPP1R12B/ARHGEF11/SSPN/MYOF/TBX3/PKP2/GSN/SMAD5/EHD3 19 GO:0030193 regulation of blood coagulation 4/982 66/18722 0.457951835423679 0.7525209705251 UBASH3B/C1QTNF1/PDGFA/ANXA2 4 GO:0042446 hormone biosynthetic process 4/982 66/18722 0.457951835423679 0.7525209705251 ADM/HSD17B1/AKR1B1/HSD17B12 4 GO:0050766 positive regulation of phagocytosis 4/982 66/18722 0.457951835423679 0.7525209705251 LRP1/CYBA/RAB31/IL2RG 4 GO:0072678 T cell migration 4/982 66/18722 0.457951835423679 0.7525209705251 CD200/APP/CCL5/F11R 4 GO:0051208 sequestering of calcium ion 7/982 122/18722 0.459404712987559 0.7525209705251 MCOLN3/UBASH3B/CHD7/P2RY6/CYBA/HSP90B1/PDPK1 7 GO:1990266 neutrophil migration 7/982 122/18722 0.459404712987559 0.7525209705251 CSF3R/JAM3/CCL5/MPP1/VAV3/DPP4/BSG 7 GO:0002709 regulation of T cell mediated immunity 5/982 85/18722 0.462504392372197 0.7525209705251 B2M/HLA-B/HLA-A/MAP3K7/HLA-E 5 GO:0055013 cardiac muscle cell development 5/982 85/18722 0.462504392372197 0.7525209705251 OBSL1/ISL1/PARP2/TBX3/LMNA 5 GO:0072384 organelle transport along microtubule 5/982 85/18722 0.462504392372197 0.7525209705251 MREG/ARHGAP21/CLN3/HDAC6/ARMCX3 5 GO:0002686 negative regulation of leukocyte migration 3/982 48/18722 0.46442660297622 0.7525209705251 CD200/WASL/DPP4 3 GO:0006111 regulation of gluconeogenesis 3/982 48/18722 0.46442660297622 0.7525209705251 SLC35B4/DDB1/RANBP2 3 GO:0030261 chromosome condensation 3/982 48/18722 0.46442660297622 0.7525209705251 SMC2/TOP2A/KMT5A 3 GO:0035036 sperm-egg recognition 3/982 48/18722 0.46442660297622 0.7525209705251 SPESP1/FOLR1/LY6K 3 GO:0042908 xenobiotic transport 3/982 48/18722 0.46442660297622 0.7525209705251 GJA1/ABCG2/SLC2A1 3 GO:0043303 mast cell degranulation 3/982 48/18722 0.46442660297622 0.7525209705251 FER/SNX4/PDPK1 3 GO:0061647 histone H3-K9 modification 3/982 48/18722 0.46442660297622 0.7525209705251 LMNA/ZNF451/DNMT1 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/982 48/18722 0.46442660297622 0.7525209705251 TIMP3/ITM2C/BCL10 3 GO:0022600 digestive system process 6/982 104/18722 0.465644234067411 0.7525209705251 ACO1/LDLR/TJP2/KCNN4/LIMA1/F11R 6 GO:0070374 positive regulation of ERK1 and ERK2 cascade 12/982 217/18722 0.467680696991686 0.7525209705251 EGFR/LRP1/APP/FGFR2/TPBG/NRP1/GCNT2/HRAS/FERMT2/P2RY6/CCL5/PDGFA 12 GO:0006690 icosanoid metabolic process 7/982 123/18722 0.467958505326079 0.7525209705251 ATP6V1B1/ABHD12/MGST3/PTGES/CYP2J2/GSTP1/AKR1B1 7 GO:0030168 platelet activation 7/982 123/18722 0.467958505326079 0.7525209705251 UBASH3B/IL6ST/FZD6/C1QTNF1/PDGFA/VAV3/F11R 7 GO:0050852 T cell receptor signaling pathway 7/982 123/18722 0.467958505326079 0.7525209705251 PAWR/TNFRSF21/HLA-A/HRAS/KCNN4/MAP3K7/BCL10 7 GO:0010959 regulation of metal ion transport 22/982 406/18722 0.468820949743818 0.7525209705251 GJA1/UBASH3B/WNK2/KCNG1/CHD7/B2M/CAMK2G/PRSS8/WFS1/FXYD3/ATP2B1/TSPAN13/KCNN4/P2RY6/CCL5/CYBA/ITGB1/PKP2/ANK3/EHD3/TRIM27/PDPK1 22 GO:0006513 protein monoubiquitination 4/982 67/18722 0.469599384074091 0.7525209705251 DDB1/TRIM37/WDR48/HUWE1 4 GO:0006879 cellular iron ion homeostasis 4/982 67/18722 0.469599384074091 0.7525209705251 TFRC/ACO1/SLC40A1/SLC11A2 4 GO:0032890 regulation of organic acid transport 4/982 67/18722 0.469599384074091 0.7525209705251 SLC43A2/PTGES/ITGB1/IRS2 4 GO:0048814 regulation of dendrite morphogenesis 4/982 67/18722 0.469599384074091 0.7525209705251 OBSL1/ANKRD27/CUX1/ID1 4 GO:0050435 amyloid-beta metabolic process 4/982 67/18722 0.469599384074091 0.7525209705251 MGAT3/MME/EFNA1/BACE2 4 GO:0051306 mitotic sister chromatid separation 4/982 67/18722 0.469599384074091 0.7525209705251 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0061371 determination of heart left/right asymmetry 4/982 67/18722 0.469599384074091 0.7525209705251 FOLR1/TBX3/NPHP3/AHI1 4 GO:0070527 platelet aggregation 4/982 67/18722 0.469599384074091 0.7525209705251 UBASH3B/IL6ST/C1QTNF1/F11R 4 GO:0006884 cell volume homeostasis 2/982 30/18722 0.471659306405857 0.7525209705251 KCNN4/CLN3 2 GO:0007202 activation of phospholipase C activity 2/982 30/18722 0.471659306405857 0.7525209705251 EGFR/P2RY6 2 GO:0010453 regulation of cell fate commitment 2/982 30/18722 0.471659306405857 0.7525209705251 ESRP1/LMO4 2 GO:0017145 stem cell division 2/982 30/18722 0.471659306405857 0.7525209705251 ETV5/NCOA3 2 GO:0034508 centromere complex assembly 2/982 30/18722 0.471659306405857 0.7525209705251 CENPF/CENPW 2 GO:0034694 response to prostaglandin 2/982 30/18722 0.471659306405857 0.7525209705251 TGFBR3/P2RY6 2 GO:0045577 regulation of B cell differentiation 2/982 30/18722 0.471659306405857 0.7525209705251 MMP14/BAD 2 GO:0048799 animal organ maturation 2/982 30/18722 0.471659306405857 0.7525209705251 PLXNB1/XYLT1 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/982 30/18722 0.471659306405857 0.7525209705251 GALNT11/RBPJ 2 GO:0070498 interleukin-1-mediated signaling pathway 2/982 30/18722 0.471659306405857 0.7525209705251 MAP3K7/RPS6KA4 2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 2/982 30/18722 0.471659306405857 0.7525209705251 WFS1/TMEM33 2 GO:0071897 DNA biosynthetic process 10/982 180/18722 0.472323045784691 0.7525209705251 GJA1/USP43/POLQ/TK1/CENPF/CHTF8/WRNIP1/PKIB/ATR/RAD50 10 GO:0060761 negative regulation of response to cytokine stimulus 5/982 86/18722 0.472759321025948 0.7525209705251 PPARG/YTHDF2/CCL5/GSTP1/METTL3 5 GO:0042098 T cell proliferation 11/982 199/18722 0.473287310528267 0.7525209705251 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/CD24/HLA-E/CCL5 11 GO:1901617 organic hydroxy compound biosynthetic process 13/982 237/18722 0.474797445772652 0.7525209705251 SLC27A2/PSAT1/SQLE/ISYNA1/CYB5R1/HSD17B1/DHCR24/MVK/P2RY6/INSIG1/AKR1B1/OPN3/SPTLC3 13 GO:2001022 positive regulation of response to DNA damage stimulus 6/982 105/18722 0.474911892584079 0.7525209705251 EGFR/BRCC3/ATR/DHX9/WDR48/TRIM28 6 GO:0000727 double-strand break repair via break-induced replication 1/982 12/18722 0.47624074457503 0.7525209705251 MCM2 1 GO:0001821 histamine secretion 1/982 12/18722 0.47624074457503 0.7525209705251 SNX4 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/982 12/18722 0.47624074457503 0.7525209705251 NAV2 1 GO:0002024 diet induced thermogenesis 1/982 12/18722 0.47624074457503 0.7525209705251 ADRB1 1 GO:0002328 pro-B cell differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 SOX4 1 GO:0002424 T cell mediated immune response to tumor cell 1/982 12/18722 0.47624074457503 0.7525209705251 HLA-A 1 GO:0002674 negative regulation of acute inflammatory response 1/982 12/18722 0.47624074457503 0.7525209705251 GSTP1 1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/982 12/18722 0.47624074457503 0.7525209705251 HLA-E 1 GO:0003207 cardiac chamber formation 1/982 12/18722 0.47624074457503 0.7525209705251 SOX4 1 GO:0003306 Wnt signaling pathway involved in heart development 1/982 12/18722 0.47624074457503 0.7525209705251 RBPJ 1 GO:0006563 L-serine metabolic process 1/982 12/18722 0.47624074457503 0.7525209705251 PSAT1 1 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 1/982 12/18722 0.47624074457503 0.7525209705251 SEC63 1 GO:0007320 insemination 1/982 12/18722 0.47624074457503 0.7525209705251 SLC6A4 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/982 12/18722 0.47624074457503 0.7525209705251 LRP1 1 GO:0010826 negative regulation of centrosome duplication 1/982 12/18722 0.47624074457503 0.7525209705251 TRIM37 1 GO:0014889 muscle atrophy 1/982 12/18722 0.47624074457503 0.7525209705251 GSN 1 GO:0016554 cytidine to uridine editing 1/982 12/18722 0.47624074457503 0.7525209705251 RBM47 1 GO:0021527 spinal cord association neuron differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 LMO4 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/982 12/18722 0.47624074457503 0.7525209705251 SLC6A4 1 GO:0021978 telencephalon regionalization 1/982 12/18722 0.47624074457503 0.7525209705251 ADGRG1 1 GO:0031223 auditory behavior 1/982 12/18722 0.47624074457503 0.7525209705251 SLC1A3 1 GO:0032096 negative regulation of response to food 1/982 12/18722 0.47624074457503 0.7525209705251 NENF 1 GO:0032099 negative regulation of appetite 1/982 12/18722 0.47624074457503 0.7525209705251 NENF 1 GO:0032105 negative regulation of response to extracellular stimulus 1/982 12/18722 0.47624074457503 0.7525209705251 NENF 1 GO:0032108 negative regulation of response to nutrient levels 1/982 12/18722 0.47624074457503 0.7525209705251 NENF 1 GO:0032306 regulation of prostaglandin secretion 1/982 12/18722 0.47624074457503 0.7525209705251 PTGES 1 GO:0032621 interleukin-18 production 1/982 12/18722 0.47624074457503 0.7525209705251 DHX9 1 GO:0032661 regulation of interleukin-18 production 1/982 12/18722 0.47624074457503 0.7525209705251 DHX9 1 GO:0032736 positive regulation of interleukin-13 production 1/982 12/18722 0.47624074457503 0.7525209705251 HLA-E 1 GO:0032926 negative regulation of activin receptor signaling pathway 1/982 12/18722 0.47624074457503 0.7525209705251 DACT2 1 GO:0033004 negative regulation of mast cell activation 1/982 12/18722 0.47624074457503 0.7525209705251 FER 1 GO:0033127 regulation of histone phosphorylation 1/982 12/18722 0.47624074457503 0.7525209705251 RPS6KA4 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/982 12/18722 0.47624074457503 0.7525209705251 DECR2 1 GO:0035092 sperm chromatin condensation 1/982 12/18722 0.47624074457503 0.7525209705251 SRPK1 1 GO:0042762 regulation of sulfur metabolic process 1/982 12/18722 0.47624074457503 0.7525209705251 COMT 1 GO:0043129 surfactant homeostasis 1/982 12/18722 0.47624074457503 0.7525209705251 EPAS1 1 GO:0043380 regulation of memory T cell differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 CD46 1 GO:0043383 negative T cell selection 1/982 12/18722 0.47624074457503 0.7525209705251 GLI3 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/982 12/18722 0.47624074457503 0.7525209705251 SCARB2 1 GO:0045117 azole transmembrane transport 1/982 12/18722 0.47624074457503 0.7525209705251 SLC19A3 1 GO:0045602 negative regulation of endothelial cell differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 ID1 1 GO:0046322 negative regulation of fatty acid oxidation 1/982 12/18722 0.47624074457503 0.7525209705251 ACADVL 1 GO:0046541 saliva secretion 1/982 12/18722 0.47624074457503 0.7525209705251 KCNN4 1 GO:0046606 negative regulation of centrosome cycle 1/982 12/18722 0.47624074457503 0.7525209705251 TRIM37 1 GO:0048742 regulation of skeletal muscle fiber development 1/982 12/18722 0.47624074457503 0.7525209705251 FBXO22 1 GO:0048934 peripheral nervous system neuron differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/982 12/18722 0.47624074457503 0.7525209705251 ISL1 1 GO:0051095 regulation of helicase activity 1/982 12/18722 0.47624074457503 0.7525209705251 MCM2 1 GO:0051549 positive regulation of keratinocyte migration 1/982 12/18722 0.47624074457503 0.7525209705251 MAP4K4 1 GO:0060009 Sertoli cell development 1/982 12/18722 0.47624074457503 0.7525209705251 RAB13 1 GO:0060123 regulation of growth hormone secretion 1/982 12/18722 0.47624074457503 0.7525209705251 CHD7 1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry 1/982 12/18722 0.47624074457503 0.7525209705251 NPHP3 1 GO:0060788 ectodermal placode formation 1/982 12/18722 0.47624074457503 0.7525209705251 TBX3 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/982 12/18722 0.47624074457503 0.7525209705251 GLI3 1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/982 12/18722 0.47624074457503 0.7525209705251 PARP2 1 GO:0061517 macrophage proliferation 1/982 12/18722 0.47624074457503 0.7525209705251 PTK2 1 GO:0070213 protein auto-ADP-ribosylation 1/982 12/18722 0.47624074457503 0.7525209705251 PARP2 1 GO:0070493 thrombin-activated receptor signaling pathway 1/982 12/18722 0.47624074457503 0.7525209705251 MET 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/982 12/18722 0.47624074457503 0.7525209705251 BRD4 1 GO:0071107 response to parathyroid hormone 1/982 12/18722 0.47624074457503 0.7525209705251 GJA1 1 GO:0071287 cellular response to manganese ion 1/982 12/18722 0.47624074457503 0.7525209705251 APP 1 GO:0071472 cellular response to salt stress 1/982 12/18722 0.47624074457503 0.7525209705251 AKR1B1 1 GO:0071697 ectodermal placode morphogenesis 1/982 12/18722 0.47624074457503 0.7525209705251 TBX3 1 GO:0071712 ER-associated misfolded protein catabolic process 1/982 12/18722 0.47624074457503 0.7525209705251 UGGT2 1 GO:0072376 protein activation cascade 1/982 12/18722 0.47624074457503 0.7525209705251 FBLN1 1 GO:0072537 fibroblast activation 1/982 12/18722 0.47624074457503 0.7525209705251 GCLM 1 GO:0072683 T cell extravasation 1/982 12/18722 0.47624074457503 0.7525209705251 F11R 1 GO:0086067 AV node cell to bundle of His cell communication 1/982 12/18722 0.47624074457503 0.7525209705251 GJA5 1 GO:0090085 regulation of protein deubiquitination 1/982 12/18722 0.47624074457503 0.7525209705251 WDR48 1 GO:0090646 mitochondrial tRNA processing 1/982 12/18722 0.47624074457503 0.7525209705251 TRIT1 1 GO:0090677 reversible differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 DNMT1 1 GO:0097152 mesenchymal cell apoptotic process 1/982 12/18722 0.47624074457503 0.7525209705251 BMP7 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/982 12/18722 0.47624074457503 0.7525209705251 PPP1R9A 1 GO:0150065 regulation of deacetylase activity 1/982 12/18722 0.47624074457503 0.7525209705251 PINK1 1 GO:1901503 ether biosynthetic process 1/982 12/18722 0.47624074457503 0.7525209705251 CHPT1 1 GO:1902563 regulation of neutrophil activation 1/982 12/18722 0.47624074457503 0.7525209705251 GRN 1 GO:1903332 regulation of protein folding 1/982 12/18722 0.47624074457503 0.7525209705251 GRN 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/982 12/18722 0.47624074457503 0.7525209705251 SLC25A4 1 GO:1903624 regulation of DNA catabolic process 1/982 12/18722 0.47624074457503 0.7525209705251 DFFA 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/982 12/18722 0.47624074457503 0.7525209705251 EGFR 1 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1/982 12/18722 0.47624074457503 0.7525209705251 LRP6 1 GO:1905666 regulation of protein localization to endosome 1/982 12/18722 0.47624074457503 0.7525209705251 MGAT3 1 GO:1990034 calcium ion export across plasma membrane 1/982 12/18722 0.47624074457503 0.7525209705251 ATP2B1 1 GO:2000009 negative regulation of protein localization to cell surface 1/982 12/18722 0.47624074457503 0.7525209705251 LEPROT 1 GO:2000035 regulation of stem cell division 1/982 12/18722 0.47624074457503 0.7525209705251 NCOA3 1 GO:2001204 regulation of osteoclast development 1/982 12/18722 0.47624074457503 0.7525209705251 FBN1 1 GO:2001214 positive regulation of vasculogenesis 1/982 12/18722 0.47624074457503 0.7525209705251 ADM 1 GO:0007368 determination of left/right symmetry 7/982 124/18722 0.47647954999644 0.752670300660639 FOLR1/GALNT11/TBX3/IFT74/NPHP3/AHI1/NEK8 7 GO:0031023 microtubule organizing center organization 8/982 143/18722 0.477673746473492 0.753176641965999 SLC16A1/TRIM37/PLK2/BRCA2/CEP152/SDCCAG8/SAC3D1/CEP135 8 GO:0000959 mitochondrial RNA metabolic process 3/982 49/18722 0.478099666708095 0.753176641965999 TRIT1/TFAM/SLIRP 3 GO:0002279 mast cell activation involved in immune response 3/982 49/18722 0.478099666708095 0.753176641965999 FER/SNX4/PDPK1 3 GO:0007602 phototransduction 3/982 49/18722 0.478099666708095 0.753176641965999 CDS1/GNA11/OPN3 3 GO:0007622 rhythmic behavior 3/982 49/18722 0.478099666708095 0.753176641965999 ADRB1/NAGLU/ZFHX3 3 GO:0009395 phospholipid catabolic process 3/982 49/18722 0.478099666708095 0.753176641965999 ABHD12/LDLR/IDH1 3 GO:0009994 oocyte differentiation 3/982 49/18722 0.478099666708095 0.753176641965999 LGR5/YTHDF2/BRCA2 3 GO:0048168 regulation of neuronal synaptic plasticity 3/982 49/18722 0.478099666708095 0.753176641965999 APP/HRAS/CLN3 3 GO:1901799 negative regulation of proteasomal protein catabolic process 3/982 49/18722 0.478099666708095 0.753176641965999 ALAD/USP14/USP25 3 GO:0007585 respiratory gaseous exchange by respiratory system 4/982 68/18722 0.481153658290163 0.757073146799846 GAA/TRAF4/FUT8/SLC5A3 4 GO:0042698 ovulation cycle 4/982 68/18722 0.481153658290163 0.757073146799846 ADAMTS1/EGFR/PTN/SERPINF1 4 GO:0042987 amyloid precursor protein catabolic process 4/982 68/18722 0.481153658290163 0.757073146799846 EFNA1/DHCR24/CLN3/FLOT2 4 GO:1900046 regulation of hemostasis 4/982 68/18722 0.481153658290163 0.757073146799846 UBASH3B/C1QTNF1/PDGFA/ANXA2 4 GO:0006605 protein targeting 17/982 314/18722 0.482144246975221 0.758403013336174 TCAF1/LMAN1/MIEF1/TRAM2/HRAS/PRKCI/PARD3/MICALL1/PINK1/ZDHHC3/ANK3/SCARB2/LEPROT/SEC63/AP1M2/SIL1/HUWE1 17 GO:0002696 positive regulation of leukocyte activation 22/982 409/18722 0.482944934916145 0.758756195516465 SOX4/TFRC/MMP14/IL6ST/GPAM/B2M/CD46/HLA-A/SNX4/GLI3/SLC39A10/YES1/CD24/CEBPA/HLA-E/CCL5/VAV3/IRS2/DPP4/FLOT2/BAD/BCL10 22 GO:0007029 endoplasmic reticulum organization 5/982 87/18722 0.482950645919222 0.758756195516465 LMAN1/TRAM2/TOR1AIP2/REEP1/TMEM33 5 GO:0044070 regulation of anion transport 5/982 87/18722 0.482950645919222 0.758756195516465 TCAF1/GABRE/SLC43A2/PTGES/ITGB1 5 GO:1901606 alpha-amino acid catabolic process 5/982 87/18722 0.482950645919222 0.758756195516465 GLDC/GSTZ1/PPAT/GCSH/CDO1 5 GO:0009185 ribonucleoside diphosphate metabolic process 6/982 106/18722 0.484132782205778 0.76038439987514 APP/TJP2/MPP1/NUPR1/DHTKD1/BAD 6 GO:0051053 negative regulation of DNA metabolic process 7/982 125/18722 0.484964438068966 0.761461321182337 GJA1/POLQ/RMI2/MAGEF1/TRIM28/RAD50/DFFA 7 GO:0033135 regulation of peptidyl-serine phosphorylation 8/982 144/18722 0.485575797436332 0.762191802415861 EGFR/APP/TFRC/TRIM6/HDAC6/BCAR3/PINK1/RICTOR 8 GO:0006633 fatty acid biosynthetic process 9/982 163/18722 0.486038957299688 0.762689290395659 ACSS1/DEGS1/PTGES/HACD3/ACADVL/GSTP1/DECR2/INSIG1/HSD17B12 9 GO:0051054 positive regulation of DNA metabolic process 11/982 201/18722 0.486678666412411 0.763166658380694 EGFR/TFRC/CHTF8/BRCC3/PKIB/ATR/DHX9/WDR48/TRIM28/RAD50/ANXA3 11 GO:0072593 reactive oxygen species metabolic process 13/982 239/18722 0.48707948325118 0.763166658380694 EGFR/BMP7/TFAP2A/PAGE4/IFI6/HDAC6/CYBA/PINK1/PRDX1/PRDX4/GSTP1/PRDX5/SLC5A3 13 GO:0051480 regulation of cytosolic calcium ion concentration 19/982 353/18722 0.487587476138235 0.763166658380694 GJA1/ITGAV/LRP1/MCOLN3/UBASH3B/SWAP70/CHD7/LRP6/TRPV6/ADM/ATP2B1/TGM2/CD24/CLN3/P2RY6/C1QTNF1/CYBA/CD52/PDPK1 19 GO:0002230 positive regulation of defense response to virus by host 2/982 31/18722 0.488976796838244 0.763166658380694 EIF2AK4/TRIM6 2 GO:0002717 positive regulation of natural killer cell mediated immunity 2/982 31/18722 0.488976796838244 0.763166658380694 CADM1/HLA-E 2 GO:0008045 motor neuron axon guidance 2/982 31/18722 0.488976796838244 0.763166658380694 NRP1/SEMA3F 2 GO:0016577 histone demethylation 2/982 31/18722 0.488976796838244 0.763166658380694 KDM5B/UTY 2 GO:0021988 olfactory lobe development 2/982 31/18722 0.488976796838244 0.763166658380694 CHD7/DLX5 2 GO:0030212 hyaluronan metabolic process 2/982 31/18722 0.488976796838244 0.763166658380694 ITIH5/CLTC 2 GO:0032148 activation of protein kinase B activity 2/982 31/18722 0.488976796838244 0.763166658380694 PINK1/PDPK1 2 GO:0033238 regulation of cellular amine metabolic process 2/982 31/18722 0.488976796838244 0.763166658380694 COMT/CLN3 2 GO:0035510 DNA dealkylation 2/982 31/18722 0.488976796838244 0.763166658380694 TET2/TRIM28 2 GO:0043171 peptide catabolic process 2/982 31/18722 0.488976796838244 0.763166658380694 ENPEP/CPQ 2 GO:0048566 embryonic digestive tract development 2/982 31/18722 0.488976796838244 0.763166658380694 FGFR2/GLI3 2 GO:0048710 regulation of astrocyte differentiation 2/982 31/18722 0.488976796838244 0.763166658380694 IL6ST/LDLR 2 GO:0055022 negative regulation of cardiac muscle tissue growth 2/982 31/18722 0.488976796838244 0.763166658380694 GJA1/VGLL4 2 GO:0061117 negative regulation of heart growth 2/982 31/18722 0.488976796838244 0.763166658380694 GJA1/VGLL4 2 GO:0070723 response to cholesterol 2/982 31/18722 0.488976796838244 0.763166658380694 DAG1/LRP6 2 GO:0002448 mast cell mediated immunity 3/982 50/18722 0.49160719811243 0.764533680703511 FER/SNX4/PDPK1 3 GO:0006220 pyrimidine nucleotide metabolic process 3/982 50/18722 0.49160719811243 0.764533680703511 NME4/DTYMK/NME1 3 GO:0007632 visual behavior 3/982 50/18722 0.49160719811243 0.764533680703511 APP/NF1/ITGB1 3 GO:0018023 peptidyl-lysine trimethylation 3/982 50/18722 0.49160719811243 0.764533680703511 BRD4/TET2/LMNA 3 GO:0045814 negative regulation of gene expression, epigenetic 3/982 50/18722 0.49160719811243 0.764533680703511 TRIM28/DNMT1/TRIM27 3 GO:0046460 neutral lipid biosynthetic process 3/982 50/18722 0.49160719811243 0.764533680703511 GPAM/LDLR/PNPLA2 3 GO:0046463 acylglycerol biosynthetic process 3/982 50/18722 0.49160719811243 0.764533680703511 GPAM/LDLR/PNPLA2 3 GO:0060337 type I interferon signaling pathway 3/982 50/18722 0.49160719811243 0.764533680703511 TRIM6/YTHDF2/METTL3 3 GO:0033344 cholesterol efflux 4/982 69/18722 0.492607475471831 0.764533680703511 LRP1/PPARG/TSKU/RXRA 4 GO:0070192 chromosome organization involved in meiotic cell cycle 4/982 69/18722 0.492607475471831 0.764533680703511 SMC2/P3H4/CCNE1/RAD50 4 GO:0050779 RNA destabilization 5/982 88/18722 0.493073055882333 0.764533680703511 LIN28B/PUM1/TARDBP/YTHDF2/METTL3 5 GO:0000018 regulation of DNA recombination 6/982 107/18722 0.493302786210763 0.764533680703511 TFRC/POLQ/RMI2/MAGEF1/WDR48/RAD50 6 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/982 107/18722 0.493302786210763 0.764533680703511 TFRC/B2M/HLA-B/HLA-A/MAP3K7/HLA-E 6 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 6/982 107/18722 0.493302786210763 0.764533680703511 APP/ISL1/HLA-E/CYBA/DHX9/BCL10 6 GO:0002819 regulation of adaptive immune response 10/982 183/18722 0.493402429156519 0.764533680703511 TFRC/EIF2AK4/IL6ST/B2M/CD46/HLA-B/HLA-A/MAP3K7/HLA-E/TRIM27 10 GO:2001235 positive regulation of apoptotic signaling pathway 7/982 126/18722 0.493409862401776 0.764533680703511 MAGED1/SIAH1/TIMP3/NUPR1/BAD/ITM2C/BCL10 7 GO:0051051 negative regulation of transport 25/982 470/18722 0.500822176831064 0.764533680703511 GJA1/ITGAV/CD200/PROM2/GABRE/FERMT1/FRMD4A/WNK2/ANKRD27/LMAN1/CYFIP1/PPP1R9A/SLC43A2/ERBB3/COMT/PACSIN2/TBC1D4/MAP4K4/NUP153/ANK3/INSIG1/IRS2/LYPLA1/TRIM27/ENY2 25 GO:0042542 response to hydrogen peroxide 8/982 146/18722 0.501282144834048 0.764533680703511 NET1/MET/PAWR/HDAC6/MDM2/PINK1/PPP2CB/BAD 8 GO:0051781 positive regulation of cell division 5/982 89/18722 0.503121484100618 0.764533680703511 FGFR2/PTN/RACGAP1/PDGFA/PGF 5 GO:0070661 leukocyte proliferation 17/982 318/18722 0.503484291797185 0.764533680703511 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/PTK2/CD24/HLA-E/CCL5/GSTP1/VAV3/IRS2/IMPDH2 17 GO:0001833 inner cell mass cell proliferation 1/982 13/18722 0.503730407259547 0.764533680703511 BRCA2 1 GO:0006000 fructose metabolic process 1/982 13/18722 0.503730407259547 0.764533680703511 AKR1B1 1 GO:0006983 ER overload response 1/982 13/18722 0.503730407259547 0.764533680703511 WFS1 1 GO:0006995 cellular response to nitrogen starvation 1/982 13/18722 0.503730407259547 0.764533680703511 GABARAPL1 1 GO:0007512 adult heart development 1/982 13/18722 0.503730407259547 0.764533680703511 CHD7 1 GO:0014029 neural crest formation 1/982 13/18722 0.503730407259547 0.764533680703511 LRP6 1 GO:0014745 negative regulation of muscle adaptation 1/982 13/18722 0.503730407259547 0.764533680703511 LMNA 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/982 13/18722 0.503730407259547 0.764533680703511 PPARD 1 GO:0015791 polyol transport 1/982 13/18722 0.503730407259547 0.764533680703511 SLC5A3 1 GO:0016246 RNA interference 1/982 13/18722 0.503730407259547 0.764533680703511 DHX9 1 GO:0016322 neuron remodeling 1/982 13/18722 0.503730407259547 0.764533680703511 APP 1 GO:0019336 phenol-containing compound catabolic process 1/982 13/18722 0.503730407259547 0.764533680703511 COMT 1 GO:0021794 thalamus development 1/982 13/18722 0.503730407259547 0.764533680703511 PTN 1 GO:0021859 pyramidal neuron differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 FGFR2 1 GO:0030497 fatty acid elongation 1/982 13/18722 0.503730407259547 0.764533680703511 HACD3 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/982 13/18722 0.503730407259547 0.764533680703511 ZDHHC3 1 GO:0032530 regulation of microvillus organization 1/982 13/18722 0.503730407259547 0.764533680703511 KLF5 1 GO:0033689 negative regulation of osteoblast proliferation 1/982 13/18722 0.503730407259547 0.764533680703511 PLXNB1 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/982 13/18722 0.503730407259547 0.764533680703511 CYBA 1 GO:0034497 protein localization to phagophore assembly site 1/982 13/18722 0.503730407259547 0.764533680703511 WIPI2 1 GO:0034982 mitochondrial protein processing 1/982 13/18722 0.503730407259547 0.764533680703511 AFG3L2 1 GO:0035845 photoreceptor cell outer segment organization 1/982 13/18722 0.503730407259547 0.764533680703511 AHI1 1 GO:0036005 response to macrophage colony-stimulating factor 1/982 13/18722 0.503730407259547 0.764533680703511 FER 1 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 1/982 13/18722 0.503730407259547 0.764533680703511 FER 1 GO:0042308 negative regulation of protein import into nucleus 1/982 13/18722 0.503730407259547 0.764533680703511 FERMT1 1 GO:0042492 gamma-delta T cell differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 SOX4 1 GO:0042538 hyperosmotic salinity response 1/982 13/18722 0.503730407259547 0.764533680703511 AKR1B1 1 GO:0042541 hemoglobin biosynthetic process 1/982 13/18722 0.503730407259547 0.764533680703511 ALAS1 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/982 13/18722 0.503730407259547 0.764533680703511 HACD3 1 GO:0042769 DNA damage response, detection of DNA damage 1/982 13/18722 0.503730407259547 0.764533680703511 SOX4 1 GO:0043379 memory T cell differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 CD46 1 GO:0043562 cellular response to nitrogen levels 1/982 13/18722 0.503730407259547 0.764533680703511 GABARAPL1 1 GO:0043970 histone H3-K9 acetylation 1/982 13/18722 0.503730407259547 0.764533680703511 ZNF451 1 GO:0046512 sphingosine biosynthetic process 1/982 13/18722 0.503730407259547 0.764533680703511 SPTLC3 1 GO:0046520 sphingoid biosynthetic process 1/982 13/18722 0.503730407259547 0.764533680703511 SPTLC3 1 GO:0048207 vesicle targeting, rough ER to cis-Golgi 1/982 13/18722 0.503730407259547 0.764533680703511 TFG 1 GO:0048208 COPII vesicle coating 1/982 13/18722 0.503730407259547 0.764533680703511 TFG 1 GO:0048266 behavioral response to pain 1/982 13/18722 0.503730407259547 0.764533680703511 VWA1 1 GO:0048711 positive regulation of astrocyte differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 IL6ST 1 GO:0051956 negative regulation of amino acid transport 1/982 13/18722 0.503730407259547 0.764533680703511 SLC43A2 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/982 13/18722 0.503730407259547 0.764533680703511 RACGAP1 1 GO:0060100 positive regulation of phagocytosis, engulfment 1/982 13/18722 0.503730407259547 0.764533680703511 RAB31 1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/982 13/18722 0.503730407259547 0.764533680703511 TRIM6 1 GO:0060707 trophoblast giant cell differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 NR2F2 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/982 13/18722 0.503730407259547 0.764533680703511 RBPJ 1 GO:0061469 regulation of type B pancreatic cell proliferation 1/982 13/18722 0.503730407259547 0.764533680703511 NUPR1 1 GO:0061744 motor behavior 1/982 13/18722 0.503730407259547 0.764533680703511 DPP4 1 GO:0070234 positive regulation of T cell apoptotic process 1/982 13/18722 0.503730407259547 0.764533680703511 CCL5 1 GO:0070316 regulation of G0 to G1 transition 1/982 13/18722 0.503730407259547 0.764533680703511 FOXO4 1 GO:0070486 leukocyte aggregation 1/982 13/18722 0.503730407259547 0.764533680703511 BMP7 1 GO:0070914 UV-damage excision repair 1/982 13/18722 0.503730407259547 0.764533680703511 DDB1 1 GO:0071801 regulation of podosome assembly 1/982 13/18722 0.503730407259547 0.764533680703511 GSN 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/982 13/18722 0.503730407259547 0.764533680703511 HOOK3 1 GO:0090161 Golgi ribbon formation 1/982 13/18722 0.503730407259547 0.764533680703511 TRIP11 1 GO:0110096 cellular response to aldehyde 1/982 13/18722 0.503730407259547 0.764533680703511 AKR1B1 1 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 1/982 13/18722 0.503730407259547 0.764533680703511 TMEM33 1 GO:1900452 regulation of long-term synaptic depression 1/982 13/18722 0.503730407259547 0.764533680703511 PPP1R9A 1 GO:1901387 positive regulation of voltage-gated calcium channel activity 1/982 13/18722 0.503730407259547 0.764533680703511 EHD3 1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/982 13/18722 0.503730407259547 0.764533680703511 TIMP3 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/982 13/18722 0.503730407259547 0.764533680703511 ANK3 1 GO:1903651 positive regulation of cytoplasmic transport 1/982 13/18722 0.503730407259547 0.764533680703511 DAB2 1 GO:1903977 positive regulation of glial cell migration 1/982 13/18722 0.503730407259547 0.764533680703511 LRP1 1 GO:1904590 negative regulation of protein import 1/982 13/18722 0.503730407259547 0.764533680703511 FERMT1 1 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 DNMT1 1 GO:1905155 positive regulation of membrane invagination 1/982 13/18722 0.503730407259547 0.764533680703511 RAB31 1 GO:1905907 negative regulation of amyloid fibril formation 1/982 13/18722 0.503730407259547 0.764533680703511 LDLR 1 GO:1905939 regulation of gonad development 1/982 13/18722 0.503730407259547 0.764533680703511 NUPR1 1 GO:1990403 embryonic brain development 1/982 13/18722 0.503730407259547 0.764533680703511 RPL10 1 GO:2001023 regulation of response to drug 1/982 13/18722 0.503730407259547 0.764533680703511 ADIRF 1 GO:2001198 regulation of dendritic cell differentiation 1/982 13/18722 0.503730407259547 0.764533680703511 HLA-B 1 GO:0002548 monocyte chemotaxis 4/982 70/18722 0.503954085643672 0.764533680703511 FLT1/CCL5/LGMN/CREB3 4 GO:0045123 cellular extravasation 4/982 70/18722 0.503954085643672 0.764533680703511 FER/JAM3/ITGB1/F11R 4 GO:0006636 unsaturated fatty acid biosynthetic process 3/982 51/18722 0.504939814749691 0.764533680703511 DEGS1/PTGES/DECR2 3 GO:0010874 regulation of cholesterol efflux 3/982 51/18722 0.504939814749691 0.764533680703511 LRP1/PPARG/RXRA 3 GO:0032873 negative regulation of stress-activated MAPK cascade 3/982 51/18722 0.504939814749691 0.764533680703511 MARVELD3/PINK1/GSTP1 3 GO:0051293 establishment of spindle localization 3/982 51/18722 0.504939814749691 0.764533680703511 GJA1/SPDL1/ITGB1 3 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 3/982 51/18722 0.504939814749691 0.764533680703511 MARVELD3/PINK1/GSTP1 3 GO:0006308 DNA catabolic process 2/982 32/18722 0.505933286172662 0.764533680703511 REXO4/DFFA 2 GO:0008156 negative regulation of DNA replication 2/982 32/18722 0.505933286172662 0.764533680703511 ATR/BRCA2 2 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 2/982 32/18722 0.505933286172662 0.764533680703511 NUPR1/PDPK1 2 GO:0010743 regulation of macrophage derived foam cell differentiation 2/982 32/18722 0.505933286172662 0.764533680703511 ITGAV/PPARG 2 GO:0030431 sleep 2/982 32/18722 0.505933286172662 0.764533680703511 ADRB1/SLC29A1 2 GO:0046475 glycerophospholipid catabolic process 2/982 32/18722 0.505933286172662 0.764533680703511 ABHD12/LDLR 2 GO:0046856 phosphatidylinositol dephosphorylation 2/982 32/18722 0.505933286172662 0.764533680703511 SYNJ1/INPPL1 2 GO:0072525 pyridine-containing compound biosynthetic process 2/982 32/18722 0.505933286172662 0.764533680703511 PSAT1/QPRT 2 GO:1901185 negative regulation of ERBB signaling pathway 2/982 32/18722 0.505933286172662 0.764533680703511 EGFR/LGMN 2 GO:1901889 negative regulation of cell junction assembly 2/982 32/18722 0.505933286172662 0.764533680703511 LRP1/MMP14 2 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/982 32/18722 0.505933286172662 0.764533680703511 WFS1/CREB3 2 GO:2000191 regulation of fatty acid transport 2/982 32/18722 0.505933286172662 0.764533680703511 PTGES/IRS2 2 GO:0002274 myeloid leukocyte activation 12/982 223/18722 0.50597589451467 0.764533680703511 CD200/APP/ITGB8/FER/LDLR/SNX4/CEBPA/CCL5/GRN/PDPK1/ANXA3/RBPJ 12 GO:0030307 positive regulation of cell growth 9/982 166/18722 0.508150451478683 0.767374856662656 EGFR/LRP1/PARP2/NRP1/MMP14/CYFIP1/CYBA/MAP3K13/USP47 9 GO:0051236 establishment of RNA localization 9/982 166/18722 0.508150451478683 0.767374856662656 IGF2BP3/NCBP3/ATR/DHX9/NUP153/RANBP2/UPF3A/TST/ENY2 9 GO:0007204 positive regulation of cytosolic calcium ion concentration 17/982 319/18722 0.508791834731946 0.768121044851471 GJA1/ITGAV/LRP1/MCOLN3/UBASH3B/SWAP70/CHD7/LRP6/TRPV6/ADM/TGM2/CD24/P2RY6/C1QTNF1/CYBA/CD52/PDPK1 17 GO:0098813 nuclear chromosome segregation 15/982 281/18722 0.510015404854995 0.769745472142262 CENPF/SMC2/P3H4/CHTF8/AXIN2/ZWINT/SPDL1/RACGAP1/FEN1/RMI2/TOP2A/KMT5A/CCNE1/KIF4A/LCMT1 15 GO:0002456 T cell mediated immunity 6/982 109/18722 0.511474437285816 0.77172423051282 B2M/CD46/HLA-B/HLA-A/MAP3K7/HLA-E 6 GO:0002028 regulation of sodium ion transport 5/982 90/18722 0.513091107461677 0.773492259109858 WNK2/PRSS8/FXYD3/PKP2/ANK3 5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 5/982 90/18722 0.513091107461677 0.773492259109858 DAB2/CEBPA/MDM2/PLK2/FBXO22 5 GO:0061097 regulation of protein tyrosine kinase activity 5/982 90/18722 0.513091107461677 0.773492259109858 APP/ERBB3/EFNA1/CD24/CCL5 5 GO:0043484 regulation of RNA splicing 8/982 148/18722 0.516840810457198 0.775403056114917 ESRP1/ESRP2/MBNL3/MBNL2/SLC38A2/ZNF326/SRPK1/HNRNPLL 8 GO:0050905 neuromuscular process 8/982 148/18722 0.516840810457198 0.775403056114917 TMEM150C/APP/IGDCC3/GAA/MYO7A/SLC1A3/CLN3/UBA5 8 GO:0097530 granulocyte migration 8/982 148/18722 0.516840810457198 0.775403056114917 CSF3R/JAM3/PTK2/CCL5/MPP1/VAV3/DPP4/BSG 8 GO:0002218 activation of innate immune response 3/982 52/18722 0.518088999866922 0.775403056114917 MAP3K7/ZCCHC3/PSPC1 3 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 3/982 52/18722 0.518088999866922 0.775403056114917 PLPP3/COG4/COPB2 3 GO:0010662 regulation of striated muscle cell apoptotic process 3/982 52/18722 0.518088999866922 0.775403056114917 BMP7/NUPR1/PDPK1 3 GO:0032206 positive regulation of telomere maintenance 3/982 52/18722 0.518088999866922 0.775403056114917 PKIB/ATR/RAD50 3 GO:0034204 lipid translocation 3/982 52/18722 0.518088999866922 0.775403056114917 TMEM30B/KCNN4/ATP10D 3 GO:0043392 negative regulation of DNA binding 3/982 52/18722 0.518088999866922 0.775403056114917 ID1/TMSB4X/ZNF593 3 GO:0071357 cellular response to type I interferon 3/982 52/18722 0.518088999866922 0.775403056114917 TRIM6/YTHDF2/METTL3 3 GO:1903426 regulation of reactive oxygen species biosynthetic process 3/982 52/18722 0.518088999866922 0.775403056114917 PAGE4/CYBA/SLC5A3 3 GO:0017038 protein import 11/982 206/18722 0.519798547879888 0.775403056114917 CDH1/FERMT1/HEATR3/GLI3/TNPO1/TARDBP/LMNA/NUP153/RANBP2/PTTG1IP/TRIM28 11 GO:0009063 cellular amino acid catabolic process 6/982 110/18722 0.520468620015241 0.775403056114917 GLDC/GSTZ1/PPAT/GCSH/CDO1/ENOSF1 6 GO:0006482 protein demethylation 2/982 33/18722 0.522518973940143 0.775403056114917 KDM5B/UTY 2 GO:0006654 phosphatidic acid biosynthetic process 2/982 33/18722 0.522518973940143 0.775403056114917 GPAM/AGPAT1 2 GO:0008214 protein dealkylation 2/982 33/18722 0.522518973940143 0.775403056114917 KDM5B/UTY 2 GO:0010259 multicellular organism aging 2/982 33/18722 0.522518973940143 0.775403056114917 CTSV/SEC63 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/982 33/18722 0.522518973940143 0.775403056114917 CLN3/ZDHHC3 2 GO:0036336 dendritic cell migration 2/982 33/18722 0.522518973940143 0.775403056114917 EPS8/CCL5 2 GO:0071539 protein localization to centrosome 2/982 33/18722 0.522518973940143 0.775403056114917 HOOK3/GOLGB1 2 GO:1902275 regulation of chromatin organization 2/982 33/18722 0.522518973940143 0.775403056114917 TRIM28/DNMT1 2 GO:1903715 regulation of aerobic respiration 2/982 33/18722 0.522518973940143 0.775403056114917 PINK1/NUPR1 2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/982 33/18722 0.522518973940143 0.775403056114917 EGFR/CCND1 2 GO:0000070 mitotic sister chromatid segregation 9/982 168/18722 0.522731485138683 0.775403056114917 CENPF/SMC2/CHTF8/ZWINT/SPDL1/RACGAP1/KMT5A/KIF4A/LCMT1 9 GO:2000241 regulation of reproductive process 9/982 168/18722 0.522731485138683 0.775403056114917 GJA1/BMP7/ASPM/SERPINF1/PHLDA2/YTHDF2/NUPR1/PRDX4/METTL3 9 GO:0002275 myeloid cell activation involved in immune response 5/982 91/18722 0.522977345341715 0.775403056114917 FER/SNX4/GRN/PDPK1/ANXA3 5 GO:0019935 cyclic-nucleotide-mediated signaling 5/982 91/18722 0.522977345341715 0.775403056114917 GNAI1/ADM/NUDT4/ADGRG6/PDE7A 5 GO:0002703 regulation of leukocyte mediated immunity 12/982 226/18722 0.524863736301162 0.775403056114917 CADM1/TFRC/FER/B2M/CD46/HLA-B/HLA-A/SNX4/MAP3K7/HLA-E/PDPK1/DDX1 12 GO:0032729 positive regulation of interferon-gamma production 4/982 72/18722 0.526300806806848 0.775403056114917 ISL1/HLA-A/HRAS/TRIM27 4 GO:0042273 ribosomal large subunit biogenesis 4/982 72/18722 0.526300806806848 0.775403056114917 HEATR3/MAK16/RPF2/RPL10 4 GO:0050709 negative regulation of protein secretion 4/982 72/18722 0.526300806806848 0.775403056114917 CD200/FRMD4A/MAP4K4/ENY2 4 GO:1905818 regulation of chromosome separation 4/982 72/18722 0.526300806806848 0.775403056114917 CENPF/ZWINT/SPDL1/LCMT1 4 GO:0051028 mRNA transport 7/982 130/18722 0.526734416492288 0.775403056114917 IGF2BP3/NCBP3/DHX9/NUP153/RANBP2/UPF3A/ENY2 7 GO:0051607 defense response to virus 14/982 265/18722 0.528141076830502 0.775403056114917 SKP2/EIF2AK4/GPAM/ELMOD2/TRIM6/IL10RB/IFI6/PUM1/NCBP3/ZCCHC3/TSPAN6/PUM2/DHX9/DDX1 14 GO:0140546 defense response to symbiont 14/982 265/18722 0.528141076830502 0.775403056114917 SKP2/EIF2AK4/GPAM/ELMOD2/TRIM6/IL10RB/IFI6/PUM1/NCBP3/ZCCHC3/TSPAN6/PUM2/DHX9/DDX1 14 GO:0001938 positive regulation of endothelial cell proliferation 6/982 111/18722 0.529396989181971 0.775403056114917 NRP2/NRP1/CYBA/RICTOR/PGF/PDPK1 6 GO:0015718 monocarboxylic acid transport 6/982 111/18722 0.529396989181971 0.775403056114917 SLC16A1/ABCG2/SLC16A12/PTGES/PLA2G12A/SLC16A4 6 GO:0000212 meiotic spindle organization 1/982 14/18722 0.529778658906942 0.775403056114917 ASPM 1 GO:0002864 regulation of acute inflammatory response to antigenic stimulus 1/982 14/18722 0.529778658906942 0.775403056114917 HLA-E 1 GO:0003214 cardiac left ventricle morphogenesis 1/982 14/18722 0.529778658906942 0.775403056114917 RBPJ 1 GO:0006287 base-excision repair, gap-filling 1/982 14/18722 0.529778658906942 0.775403056114917 FEN1 1 GO:0006999 nuclear pore organization 1/982 14/18722 0.529778658906942 0.775403056114917 NUP153 1 GO:0007638 mechanosensory behavior 1/982 14/18722 0.529778658906942 0.775403056114917 SLC1A3 1 GO:0009214 cyclic nucleotide catabolic process 1/982 14/18722 0.529778658906942 0.775403056114917 PDE7A 1 GO:0010457 centriole-centriole cohesion 1/982 14/18722 0.529778658906942 0.775403056114917 CEP135 1 GO:0010867 positive regulation of triglyceride biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 LDLR 1 GO:0010896 regulation of triglyceride catabolic process 1/982 14/18722 0.529778658906942 0.775403056114917 PNPLA2 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/982 14/18722 0.529778658906942 0.775403056114917 DAG1 1 GO:0022038 corpus callosum development 1/982 14/18722 0.529778658906942 0.775403056114917 TSKU 1 GO:0030213 hyaluronan biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 CLTC 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/982 14/18722 0.529778658906942 0.775403056114917 EPN2 1 GO:0031054 pre-miRNA processing 1/982 14/18722 0.529778658906942 0.775403056114917 LIN28B 1 GO:0031650 regulation of heat generation 1/982 14/18722 0.529778658906942 0.775403056114917 PTGES 1 GO:0032966 negative regulation of collagen biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 PPARD 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/982 14/18722 0.529778658906942 0.775403056114917 SNX4 1 GO:0033212 iron import into cell 1/982 14/18722 0.529778658906942 0.775403056114917 SLC11A2 1 GO:0033605 positive regulation of catecholamine secretion 1/982 14/18722 0.529778658906942 0.775403056114917 PINK1 1 GO:0034616 response to laminar fluid shear stress 1/982 14/18722 0.529778658906942 0.775403056114917 ASS1 1 GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 1/982 14/18722 0.529778658906942 0.775403056114917 P2RY6 1 GO:0035641 locomotory exploration behavior 1/982 14/18722 0.529778658906942 0.775403056114917 DPP4 1 GO:0036444 calcium import into the mitochondrion 1/982 14/18722 0.529778658906942 0.775403056114917 AFG3L2 1 GO:0043173 nucleotide salvage 1/982 14/18722 0.529778658906942 0.775403056114917 ADK 1 GO:0043306 positive regulation of mast cell degranulation 1/982 14/18722 0.529778658906942 0.775403056114917 SNX4 1 GO:0043455 regulation of secondary metabolic process 1/982 14/18722 0.529778658906942 0.775403056114917 OPN3 1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1/982 14/18722 0.529778658906942 0.775403056114917 ATR 1 GO:0043558 regulation of translational initiation in response to stress 1/982 14/18722 0.529778658906942 0.775403056114917 EIF2AK4 1 GO:0044764 multi-organism cellular process 1/982 14/18722 0.529778658906942 0.775403056114917 CTSL 1 GO:0045023 G0 to G1 transition 1/982 14/18722 0.529778658906942 0.775403056114917 FOXO4 1 GO:0045472 response to ether 1/982 14/18722 0.529778658906942 0.775403056114917 MDM2 1 GO:0045820 negative regulation of glycolytic process 1/982 14/18722 0.529778658906942 0.775403056114917 NUPR1 1 GO:0045837 negative regulation of membrane potential 1/982 14/18722 0.529778658906942 0.775403056114917 PTN 1 GO:0046462 monoacylglycerol metabolic process 1/982 14/18722 0.529778658906942 0.775403056114917 ABHD12 1 GO:0046479 glycosphingolipid catabolic process 1/982 14/18722 0.529778658906942 0.775403056114917 NEU1 1 GO:0048021 regulation of melanin biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 OPN3 1 GO:0048172 regulation of short-term neuronal synaptic plasticity 1/982 14/18722 0.529778658906942 0.775403056114917 CLN3 1 GO:0048368 lateral mesoderm development 1/982 14/18722 0.529778658906942 0.775403056114917 YAP1 1 GO:0048875 chemical homeostasis within a tissue 1/982 14/18722 0.529778658906942 0.775403056114917 EPAS1 1 GO:0050930 induction of positive chemotaxis 1/982 14/18722 0.529778658906942 0.775403056114917 PGF 1 GO:0051547 regulation of keratinocyte migration 1/982 14/18722 0.529778658906942 0.775403056114917 MAP4K4 1 GO:0051589 negative regulation of neurotransmitter transport 1/982 14/18722 0.529778658906942 0.775403056114917 PPP1R9A 1 GO:0051764 actin crosslink formation 1/982 14/18722 0.529778658906942 0.775403056114917 EPS8 1 GO:0060732 positive regulation of inositol phosphate biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 P2RY6 1 GO:0060841 venous blood vessel development 1/982 14/18722 0.529778658906942 0.775403056114917 ACVR2B 1 GO:0061709 reticulophagy 1/982 14/18722 0.529778658906942 0.775403056114917 UBA5 1 GO:0070307 lens fiber cell development 1/982 14/18722 0.529778658906942 0.775403056114917 VIM 1 GO:0070986 left/right axis specification 1/982 14/18722 0.529778658906942 0.775403056114917 AHI1 1 GO:0071236 cellular response to antibiotic 1/982 14/18722 0.529778658906942 0.775403056114917 MDM2 1 GO:0071415 cellular response to purine-containing compound 1/982 14/18722 0.529778658906942 0.775403056114917 P2RY6 1 GO:0072176 nephric duct development 1/982 14/18722 0.529778658906942 0.775403056114917 AHI1 1 GO:0072498 embryonic skeletal joint development 1/982 14/18722 0.529778658906942 0.775403056114917 BMP7 1 GO:0090281 negative regulation of calcium ion import 1/982 14/18722 0.529778658906942 0.775403056114917 TRIM27 1 GO:0090715 immunological memory formation process 1/982 14/18722 0.529778658906942 0.775403056114917 CD46 1 GO:0099188 postsynaptic cytoskeleton organization 1/982 14/18722 0.529778658906942 0.775403056114917 PPP1R9A 1 GO:0099638 endosome to plasma membrane protein transport 1/982 14/18722 0.529778658906942 0.775403056114917 NSG1 1 GO:1900037 regulation of cellular response to hypoxia 1/982 14/18722 0.529778658906942 0.775403056114917 PINK1 1 GO:1900376 regulation of secondary metabolite biosynthetic process 1/982 14/18722 0.529778658906942 0.775403056114917 OPN3 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/982 14/18722 0.529778658906942 0.775403056114917 BMP7 1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/982 14/18722 0.529778658906942 0.775403056114917 TRIAP1 1 GO:1902187 negative regulation of viral release from host cell 1/982 14/18722 0.529778658906942 0.775403056114917 TRIM28 1 GO:1902916 positive regulation of protein polyubiquitination 1/982 14/18722 0.529778658906942 0.775403056114917 SKP2 1 GO:1903894 regulation of IRE1-mediated unfolded protein response 1/982 14/18722 0.529778658906942 0.775403056114917 TMEM33 1 GO:1905208 negative regulation of cardiocyte differentiation 1/982 14/18722 0.529778658906942 0.775403056114917 EGFR 1 GO:2001140 positive regulation of phospholipid transport 1/982 14/18722 0.529778658906942 0.775403056114917 TRIAP1 1 GO:0006937 regulation of muscle contraction 9/982 169/18722 0.529967771290199 0.775403056114917 GJA5/DSG2/DSP/DSC2/CTTN/ATP2B1/PPP1R12B/PKP2/EHD3 9 GO:0018394 peptidyl-lysine acetylation 9/982 169/18722 0.529967771290199 0.775403056114917 ISL1/SOX4/MAP3K7/NCOA3/MORF4L2/ZNF451/BRCA2/RPS6KA4/MED24 9 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 3/982 53/18722 0.531047067529766 0.776328896926923 MET/ADM/CCL5 3 GO:0045806 negative regulation of endocytosis 3/982 53/18722 0.531047067529766 0.776328896926923 ITGAV/PROM2/PACSIN2 3 GO:1903202 negative regulation of oxidative stress-induced cell death 3/982 53/18722 0.531047067529766 0.776328896926923 MET/PAGE4/PINK1 3 GO:0050867 positive regulation of cell activation 22/982 420/18722 0.534195824021869 0.78071320204485 SOX4/TFRC/MMP14/IL6ST/GPAM/B2M/CD46/HLA-A/SNX4/GLI3/SLC39A10/YES1/CD24/CEBPA/HLA-E/CCL5/VAV3/IRS2/DPP4/FLOT2/BAD/BCL10 22 GO:0043487 regulation of RNA stability 9/982 170/18722 0.537165264883968 0.781857324122331 LIN28B/AXIN2/PUM1/TARDBP/YTHDF2/PUM2/DHX9/METTL3/VIM 9 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 4/982 73/18722 0.5372895159753 0.781857324122331 EGFR/FER/IFI6/BCAR3 4 GO:0043299 leukocyte degranulation 4/982 73/18722 0.5372895159753 0.781857324122331 FER/SNX4/PDPK1/ANXA3 4 GO:0070988 demethylation 4/982 73/18722 0.5372895159753 0.781857324122331 KDM5B/UTY/TET2/TRIM28 4 GO:0099518 vesicle cytoskeletal trafficking 4/982 73/18722 0.5372895159753 0.781857324122331 MYO7A/WASL/FNBP1L/CLN3 4 GO:0002526 acute inflammatory response 6/982 112/18722 0.538256199406772 0.781857324122331 IL6ST/PTGES/HLA-E/NUPR1/GSTP1/ASS1 6 GO:0000038 very long-chain fatty acid metabolic process 2/982 34/18722 0.538726078009137 0.781857324122331 SLC27A2/HACD3 2 GO:0002183 cytoplasmic translational initiation 2/982 34/18722 0.538726078009137 0.781857324122331 YTHDF2/METTL3 2 GO:0006356 regulation of transcription by RNA polymerase I 2/982 34/18722 0.538726078009137 0.781857324122331 WDR43/HEATR1 2 GO:0007616 long-term memory 2/982 34/18722 0.538726078009137 0.781857324122331 EIF2AK4/LDLR 2 GO:0009112 nucleobase metabolic process 2/982 34/18722 0.538726078009137 0.781857324122331 PPAT/RRM1 2 GO:0009303 rRNA transcription 2/982 34/18722 0.538726078009137 0.781857324122331 SPIN1/NPM3 2 GO:0019076 viral release from host cell 2/982 34/18722 0.538726078009137 0.781857324122331 DDB1/TRIM28 2 GO:0032212 positive regulation of telomere maintenance via telomerase 2/982 34/18722 0.538726078009137 0.781857324122331 PKIB/ATR 2 GO:0034383 low-density lipoprotein particle clearance 2/982 34/18722 0.538726078009137 0.781857324122331 LDLR/ANXA2 2 GO:0035137 hindlimb morphogenesis 2/982 34/18722 0.538726078009137 0.781857324122331 CHD7/TBX3 2 GO:0035890 exit from host 2/982 34/18722 0.538726078009137 0.781857324122331 DDB1/TRIM28 2 GO:0035891 exit from host cell 2/982 34/18722 0.538726078009137 0.781857324122331 DDB1/TRIM28 2 GO:0044319 wound healing, spreading of cells 2/982 34/18722 0.538726078009137 0.781857324122331 FERMT1/FERMT2 2 GO:0048741 skeletal muscle fiber development 2/982 34/18722 0.538726078009137 0.781857324122331 BIN3/FBXO22 2 GO:0050869 negative regulation of B cell activation 2/982 34/18722 0.538726078009137 0.781857324122331 PAWR/TNFRSF21 2 GO:0051085 chaperone cofactor-dependent protein refolding 2/982 34/18722 0.538726078009137 0.781857324122331 DNAJB4/BAG1 2 GO:0090505 epiboly involved in wound healing 2/982 34/18722 0.538726078009137 0.781857324122331 FERMT1/FERMT2 2 GO:0098751 bone cell development 2/982 34/18722 0.538726078009137 0.781857324122331 FBN1/ANXA2 2 GO:1904893 negative regulation of receptor signaling pathway via STAT 2/982 34/18722 0.538726078009137 0.781857324122331 PPARG/LEPROT 2 GO:1904064 positive regulation of cation transmembrane transport 8/982 151/18722 0.539859037557486 0.783245534646237 WNK2/TMSB4X/KCNN4/P2RY6/PINK1/ANK3/EHD3/PDPK1 8 GO:0019217 regulation of fatty acid metabolic process 5/982 93/18722 0.542482543709673 0.783245534646237 PPARG/PPARD/ACADVL/INSIG1/IRS2 5 GO:0032088 negative regulation of NF-kappaB transcription factor activity 5/982 93/18722 0.542482543709673 0.783245534646237 CD200/BMP7/TMSB4X/TRIM37/NLRP2 5 GO:0032755 positive regulation of interleukin-6 production 5/982 93/18722 0.542482543709673 0.783245534646237 APP/ISL1/CYBA/DHX9/BCL10 5 GO:0071356 cellular response to tumor necrosis factor 12/982 229/18722 0.543527955274849 0.783245534646237 TNFRSF21/TMSB4X/SPATA2/CEBPA/KRT18/SPPL2B/CCL5/CYBA/GSTP1/DHX9/KRT8/ASS1 12 GO:0006584 catecholamine metabolic process 3/982 54/18722 0.543807127457836 0.783245534646237 EPAS1/COMT/AKR1B1 3 GO:0006968 cellular defense response 3/982 54/18722 0.543807127457836 0.783245534646237 LGALS3BP/ITGB1/BCL10 3 GO:0009712 catechol-containing compound metabolic process 3/982 54/18722 0.543807127457836 0.783245534646237 EPAS1/COMT/AKR1B1 3 GO:0014888 striated muscle adaptation 3/982 54/18722 0.543807127457836 0.783245534646237 CAMK2G/LMNA/GSN 3 GO:0035065 regulation of histone acetylation 3/982 54/18722 0.543807127457836 0.783245534646237 ISL1/ZNF451/RPS6KA4 3 GO:0043647 inositol phosphate metabolic process 3/982 54/18722 0.543807127457836 0.783245534646237 SYNJ1/NUDT4/P2RY6 3 GO:0046890 regulation of lipid biosynthetic process 9/982 171/18722 0.544322060657353 0.783245534646237 SORBS1/RDH10/ADM/LDLR/RAB38/ACADVL/PDGFA/IDH1/INSIG1 9 GO:0016573 histone acetylation 8/982 152/18722 0.54743732738739 0.783245534646237 ISL1/MAP3K7/NCOA3/MORF4L2/ZNF451/BRCA2/RPS6KA4/MED24 8 GO:0002437 inflammatory response to antigenic stimulus 4/982 74/18722 0.548148197037667 0.783245534646237 YES1/HLA-E/PLK2/RBPJ 4 GO:0010822 positive regulation of mitochondrion organization 4/982 74/18722 0.548148197037667 0.783245534646237 MIEF1/SLC25A4/PINK1/BAD 4 GO:0046651 lymphocyte proliferation 15/982 288/18722 0.549070696124382 0.783245534646237 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2/IMPDH2 15 GO:0009855 determination of bilateral symmetry 7/982 133/18722 0.551166985918641 0.783245534646237 FOLR1/GALNT11/TBX3/IFT74/NPHP3/AHI1/NEK8 7 GO:0030316 osteoclast differentiation 5/982 94/18722 0.55209353739117 0.783245534646237 FBN1/TFRC/UBASH3B/ESRRA/ANXA2 5 GO:0051702 biological process involved in interaction with symbiont 5/982 94/18722 0.55209353739117 0.783245534646237 EIF2AK4/DDB1/TARDBP/CCL5/TAF11 5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/982 15/18722 0.554461006402847 0.783245534646237 RPF2 1 GO:0002070 epithelial cell maturation 1/982 15/18722 0.554461006402847 0.783245534646237 AKR1B1 1 GO:0002679 respiratory burst involved in defense response 1/982 15/18722 0.554461006402847 0.783245534646237 GRN 1 GO:0002730 regulation of dendritic cell cytokine production 1/982 15/18722 0.554461006402847 0.783245534646237 DDX1 1 GO:0006268 DNA unwinding involved in DNA replication 1/982 15/18722 0.554461006402847 0.783245534646237 MCM2 1 GO:0006570 tyrosine metabolic process 1/982 15/18722 0.554461006402847 0.783245534646237 GSTZ1 1 GO:0006825 copper ion transport 1/982 15/18722 0.554461006402847 0.783245534646237 SLC11A2 1 GO:0010452 histone H3-K36 methylation 1/982 15/18722 0.554461006402847 0.783245534646237 BRD4 1 GO:0010820 positive regulation of T cell chemotaxis 1/982 15/18722 0.554461006402847 0.783245534646237 CCL5 1 GO:0010832 negative regulation of myotube differentiation 1/982 15/18722 0.554461006402847 0.783245534646237 BHLHE41 1 GO:0014733 regulation of skeletal muscle adaptation 1/982 15/18722 0.554461006402847 0.783245534646237 CAMK2G 1 GO:0014841 skeletal muscle satellite cell proliferation 1/982 15/18722 0.554461006402847 0.783245534646237 PPARD 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/982 15/18722 0.554461006402847 0.783245534646237 PPARD 1 GO:0015697 quaternary ammonium group transport 1/982 15/18722 0.554461006402847 0.783245534646237 SLC38A2 1 GO:0016114 terpenoid biosynthetic process 1/982 15/18722 0.554461006402847 0.783245534646237 RDH10 1 GO:0016446 somatic hypermutation of immunoglobulin genes 1/982 15/18722 0.554461006402847 0.783245534646237 POLQ 1 GO:0018298 protein-chromophore linkage 1/982 15/18722 0.554461006402847 0.783245534646237 OPN3 1 GO:0021542 dentate gyrus development 1/982 15/18722 0.554461006402847 0.783245534646237 CDK6 1 GO:0023035 CD40 signaling pathway 1/982 15/18722 0.554461006402847 0.783245534646237 ITGB1 1 GO:0030252 growth hormone secretion 1/982 15/18722 0.554461006402847 0.783245534646237 CHD7 1 GO:0032310 prostaglandin secretion 1/982 15/18722 0.554461006402847 0.783245534646237 PTGES 1 GO:0032328 alanine transport 1/982 15/18722 0.554461006402847 0.783245534646237 SLC38A2 1 GO:0032486 Rap protein signal transduction 1/982 15/18722 0.554461006402847 0.783245534646237 PLK2 1 GO:0032488 Cdc42 protein signal transduction 1/982 15/18722 0.554461006402847 0.783245534646237 NRP1 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/982 15/18722 0.554461006402847 0.783245534646237 ISL1 1 GO:0032897 negative regulation of viral transcription 1/982 15/18722 0.554461006402847 0.783245534646237 TRIM27 1 GO:0032933 SREBP signaling pathway 1/982 15/18722 0.554461006402847 0.783245534646237 INSIG1 1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/982 15/18722 0.554461006402847 0.783245534646237 ISL1 1 GO:0034384 high-density lipoprotein particle clearance 1/982 15/18722 0.554461006402847 0.783245534646237 LDLR 1 GO:0034638 phosphatidylcholine catabolic process 1/982 15/18722 0.554461006402847 0.783245534646237 LDLR 1 GO:0035493 SNARE complex assembly 1/982 15/18722 0.554461006402847 0.783245534646237 ANKRD27 1 GO:0036124 histone H3-K9 trimethylation 1/982 15/18722 0.554461006402847 0.783245534646237 LMNA 1 GO:0042559 pteridine-containing compound biosynthetic process 1/982 15/18722 0.554461006402847 0.783245534646237 ATIC 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/982 15/18722 0.554461006402847 0.783245534646237 TMSB4X 1 GO:0043508 negative regulation of JUN kinase activity 1/982 15/18722 0.554461006402847 0.783245534646237 GSTP1 1 GO:0044793 negative regulation by host of viral process 1/982 15/18722 0.554461006402847 0.783245534646237 EIF2AK4 1 GO:0048712 negative regulation of astrocyte differentiation 1/982 15/18722 0.554461006402847 0.783245534646237 LDLR 1 GO:0050746 regulation of lipoprotein metabolic process 1/982 15/18722 0.554461006402847 0.783245534646237 ITGAV 1 GO:0051290 protein heterotetramerization 1/982 15/18722 0.554461006402847 0.783245534646237 RRM1 1 GO:0051608 histamine transport 1/982 15/18722 0.554461006402847 0.783245534646237 SNX4 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/982 15/18722 0.554461006402847 0.783245534646237 LMNA 1 GO:0055091 phospholipid homeostasis 1/982 15/18722 0.554461006402847 0.783245534646237 GPAM 1 GO:0060099 regulation of phagocytosis, engulfment 1/982 15/18722 0.554461006402847 0.783245534646237 RAB31 1 GO:0060253 negative regulation of glial cell proliferation 1/982 15/18722 0.554461006402847 0.783245534646237 PTN 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/982 15/18722 0.554461006402847 0.783245534646237 PGAP1 1 GO:0060766 negative regulation of androgen receptor signaling pathway 1/982 15/18722 0.554461006402847 0.783245534646237 DAB2 1 GO:0070207 protein homotrimerization 1/982 15/18722 0.554461006402847 0.783245534646237 SLC1A5 1 GO:0071380 cellular response to prostaglandin E stimulus 1/982 15/18722 0.554461006402847 0.783245534646237 P2RY6 1 GO:0072224 metanephric glomerulus development 1/982 15/18722 0.554461006402847 0.783245534646237 LGR4 1 GO:0090110 COPII-coated vesicle cargo loading 1/982 15/18722 0.554461006402847 0.783245534646237 INSIG1 1 GO:0090594 inflammatory response to wounding 1/982 15/18722 0.554461006402847 0.783245534646237 GRN 1 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 1/982 15/18722 0.554461006402847 0.783245534646237 WFS1 1 GO:1901660 calcium ion export 1/982 15/18722 0.554461006402847 0.783245534646237 ATP2B1 1 GO:1903727 positive regulation of phospholipid metabolic process 1/982 15/18722 0.554461006402847 0.783245534646237 RAB38 1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 1/982 15/18722 0.554461006402847 0.783245534646237 LIN28B 1 GO:1904380 endoplasmic reticulum mannose trimming 1/982 15/18722 0.554461006402847 0.783245534646237 UGGT2 1 GO:1904424 regulation of GTP binding 1/982 15/18722 0.554461006402847 0.783245534646237 MET 1 GO:1904889 regulation of excitatory synapse assembly 1/982 15/18722 0.554461006402847 0.783245534646237 VSTM5 1 GO:1905168 positive regulation of double-strand break repair via homologous recombination 1/982 15/18722 0.554461006402847 0.783245534646237 WDR48 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/982 15/18722 0.554461006402847 0.783245534646237 DAB2 1 GO:2000104 negative regulation of DNA-dependent DNA replication 1/982 15/18722 0.554461006402847 0.783245534646237 BRCA2 1 GO:2000345 regulation of hepatocyte proliferation 1/982 15/18722 0.554461006402847 0.783245534646237 PTN 1 GO:2001138 regulation of phospholipid transport 1/982 15/18722 0.554461006402847 0.783245534646237 TRIAP1 1 GO:0000460 maturation of 5.8S rRNA 2/982 35/18722 0.554548650201026 0.783245534646237 MAK16/ERI2 2 GO:0000731 DNA synthesis involved in DNA repair 2/982 35/18722 0.554548650201026 0.783245534646237 USP43/WRNIP1 2 GO:0001569 branching involved in blood vessel morphogenesis 2/982 35/18722 0.554548650201026 0.783245534646237 NRP1/COL4A1 2 GO:0006084 acetyl-CoA metabolic process 2/982 35/18722 0.554548650201026 0.783245534646237 ACSS1/MVK 2 GO:0018149 peptide cross-linking 2/982 35/18722 0.554548650201026 0.783245534646237 DSP/TGM2 2 GO:0021955 central nervous system neuron axonogenesis 2/982 35/18722 0.554548650201026 0.783245534646237 NFIB/TSKU 2 GO:0039694 viral RNA genome replication 2/982 35/18722 0.554548650201026 0.783245534646237 TOP2A/TRIM28 2 GO:0045922 negative regulation of fatty acid metabolic process 2/982 35/18722 0.554548650201026 0.783245534646237 ACADVL/INSIG1 2 GO:0046640 regulation of alpha-beta T cell proliferation 2/982 35/18722 0.554548650201026 0.783245534646237 HLA-A/HLA-E 2 GO:0048821 erythrocyte development 2/982 35/18722 0.554548650201026 0.783245534646237 SLC11A2/ALAS1 2 GO:0071108 protein K48-linked deubiquitination 2/982 35/18722 0.554548650201026 0.783245534646237 USP27X/USP25 2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2/982 35/18722 0.554548650201026 0.783245534646237 NRP1/PLK2 2 GO:0090181 regulation of cholesterol metabolic process 2/982 35/18722 0.554548650201026 0.783245534646237 LDLR/ACADVL 2 GO:0090504 epiboly 2/982 35/18722 0.554548650201026 0.783245534646237 FERMT1/FERMT2 2 GO:0097502 mannosylation 2/982 35/18722 0.554548650201026 0.783245534646237 TMTC3/B4GAT1 2 GO:1905508 protein localization to microtubule organizing center 2/982 35/18722 0.554548650201026 0.783245534646237 HOOK3/GOLGB1 2 GO:2000403 positive regulation of lymphocyte migration 2/982 35/18722 0.554548650201026 0.783245534646237 APP/CCL5 2 GO:0000910 cytokinesis 9/982 173/18722 0.558506236298616 0.788621691535891 MYH10/RASA1/RACGAP1/PLK2/BIN3/ANK3/BRCA2/STAMBP/KIF4A 9 GO:1902369 negative regulation of RNA catabolic process 4/982 75/18722 0.558872145974177 0.78892479388398 AXIN2/TARDBP/DHX9/SLIRP 4 GO:0009799 specification of symmetry 7/982 134/18722 0.559190230578078 0.789160238824474 FOLR1/GALNT11/TBX3/IFT74/NPHP3/AHI1/NEK8 7 GO:1901379 regulation of potassium ion transmembrane transport 5/982 95/18722 0.561605206235191 0.792354004793821 WNK2/KCNG1/KCNN4/ITGB1/ANK3 5 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 10/982 193/18722 0.561838842647821 0.7924692815714 ISL1/NRP1/IL6ST/EFNA5/ERBB3/EFNA1/YES1/CD24/CCL5/RICTOR 10 GO:0051168 nuclear export 8/982 154/18722 0.562439397917699 0.793101892278648 PTPN14/MDM2/ABCE1/DHX9/NUP153/LSG1/TCF7L2/ENY2 8 GO:0051209 release of sequestered calcium ion into cytosol 6/982 115/18722 0.564387732320953 0.793591471991899 MCOLN3/UBASH3B/CHD7/P2RY6/CYBA/PDPK1 6 GO:0016236 macroautophagy 15/982 291/18722 0.565492833688651 0.793591471991899 ATP6V1B1/WIPI2/SLC25A4/MAP3K7/CLN3/HDAC6/PINK1/UBA5/TBC1D12/NUPR1/GABARAPL1/ATP6V1H/ATP6V1C2/HUWE1/PHF23 15 GO:0032943 mononuclear cell proliferation 15/982 291/18722 0.565492833688651 0.793591471991899 TFRC/PAWR/IL6ST/GPAM/DLG5/TNFRSF21/CD46/HLA-A/SLC39A10/CD24/HLA-E/CCL5/VAV3/IRS2/IMPDH2 15 GO:0010658 striated muscle cell apoptotic process 3/982 56/18722 0.568709429837608 0.793591471991899 BMP7/NUPR1/PDPK1 3 GO:0022029 telencephalon cell migration 3/982 56/18722 0.568709429837608 0.793591471991899 LAMB1/ADGRG1/GLI3 3 GO:0043470 regulation of carbohydrate catabolic process 3/982 56/18722 0.568709429837608 0.793591471991899 APP/NUPR1/SCARB2 3 GO:0045599 negative regulation of fat cell differentiation 3/982 56/18722 0.568709429837608 0.793591471991899 YAP1/FERMT2/INSIG1 3 GO:0048255 mRNA stabilization 3/982 56/18722 0.568709429837608 0.793591471991899 AXIN2/TARDBP/DHX9 3 GO:0098781 ncRNA transcription 3/982 56/18722 0.568709429837608 0.793591471991899 SPIN1/NPM3/ELL 3 GO:0043536 positive regulation of blood vessel endothelial cell migration 4/982 76/18722 0.569457039755079 0.793591471991899 NRP1/TMSB4X/PLK2/PDPK1 4 GO:0140115 export across plasma membrane 4/982 76/18722 0.569457039755079 0.793591471991899 GJA1/ABCG2/ATP2B1/SLC40A1 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/982 76/18722 0.569457039755079 0.793591471991899 EGFR/CYBA/GSTP1/SLC5A3 4 GO:0006665 sphingolipid metabolic process 8/982 155/18722 0.569859177812541 0.793591471991899 PLPP3/ITGB8/DEGS1/HACD3/SERINC2/PSAP/SPTLC3/NEU1 8 GO:0008207 C21-steroid hormone metabolic process 2/982 36/18722 0.569982405663399 0.793591471991899 ADM/AKR1B1 2 GO:0014046 dopamine secretion 2/982 36/18722 0.569982405663399 0.793591471991899 SYT7/PINK1 2 GO:0014059 regulation of dopamine secretion 2/982 36/18722 0.569982405663399 0.793591471991899 SYT7/PINK1 2 GO:0030224 monocyte differentiation 2/982 36/18722 0.569982405663399 0.793591471991899 PPARG/CDK6 2 GO:0044060 regulation of endocrine process 2/982 36/18722 0.569982405663399 0.793591471991899 GJA1/C1QTNF1 2 GO:0045652 regulation of megakaryocyte differentiation 2/982 36/18722 0.569982405663399 0.793591471991899 SCIN/RCOR1 2 GO:0046466 membrane lipid catabolic process 2/982 36/18722 0.569982405663399 0.793591471991899 FUCA1/NEU1 2 GO:0051955 regulation of amino acid transport 2/982 36/18722 0.569982405663399 0.793591471991899 SLC43A2/ITGB1 2 GO:0070306 lens fiber cell differentiation 2/982 36/18722 0.569982405663399 0.793591471991899 KDM5B/VIM 2 GO:0070897 transcription preinitiation complex assembly 2/982 36/18722 0.569982405663399 0.793591471991899 CAND1/TAF11 2 GO:1901658 glycosyl compound catabolic process 2/982 36/18722 0.569982405663399 0.793591471991899 FUCA1/GUSB 2 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/982 36/18722 0.569982405663399 0.793591471991899 TRIAP1/USP47 2 GO:0034612 response to tumor necrosis factor 13/982 253/18722 0.57088560123482 0.793591471991899 TNFRSF21/TMSB4X/GSS/SPATA2/CEBPA/KRT18/SPPL2B/CCL5/CYBA/GSTP1/DHX9/KRT8/ASS1 13 GO:0051304 chromosome separation 5/982 96/18722 0.571014146898669 0.793591471991899 CENPF/ZWINT/SPDL1/TOP2A/LCMT1 5 GO:0019216 regulation of lipid metabolic process 17/982 331/18722 0.571252578702687 0.793591471991899 SORBS1/PPARG/RDH10/ADM/FLT1/LDLR/RAB38/PTK2/PPARD/ACADVL/PDGFA/PNPLA2/IDH1/PSAP/INSIG1/VAV3/IRS2 17 GO:0072330 monocarboxylic acid biosynthetic process 11/982 214/18722 0.571317334294996 0.793591471991899 SLC27A2/ACSS1/RDH10/DEGS1/PTGES/HACD3/ACADVL/GSTP1/DECR2/INSIG1/HSD17B12 11 GO:0030518 intracellular steroid hormone receptor signaling pathway 6/982 116/18722 0.572939926470063 0.793591471991899 SKP2/ISL1/YAP1/DAB2/HDAC6/UBA5 6 GO:0051283 negative regulation of sequestering of calcium ion 6/982 116/18722 0.572939926470063 0.793591471991899 MCOLN3/UBASH3B/CHD7/P2RY6/CYBA/PDPK1 6 GO:0001764 neuron migration 8/982 156/18722 0.57722225189921 0.793591471991899 NR2F2/SEMA6A/NRP2/NRP1/ADGRG1/ASPM/PLXNB2/SDCCAG8 8 GO:0002371 dendritic cell cytokine production 1/982 16/18722 0.577849005104531 0.793591471991899 DDX1 1 GO:0002399 MHC class II protein complex assembly 1/982 16/18722 0.577849005104531 0.793591471991899 B2M 1 GO:0002503 peptide antigen assembly with MHC class II protein complex 1/982 16/18722 0.577849005104531 0.793591471991899 B2M 1 GO:0002566 somatic diversification of immune receptors via somatic mutation 1/982 16/18722 0.577849005104531 0.793591471991899 POLQ 1 GO:0002693 positive regulation of cellular extravasation 1/982 16/18722 0.577849005104531 0.793591471991899 JAM3 1 GO:0002713 negative regulation of B cell mediated immunity 1/982 16/18722 0.577849005104531 0.793591471991899 CD46 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/982 16/18722 0.577849005104531 0.793591471991899 CD46 1 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 1/982 16/18722 0.577849005104531 0.793591471991899 RBPJ 1 GO:0006206 pyrimidine nucleobase metabolic process 1/982 16/18722 0.577849005104531 0.793591471991899 RRM1 1 GO:0006266 DNA ligation 1/982 16/18722 0.577849005104531 0.793591471991899 TOP2A 1 GO:0006555 methionine metabolic process 1/982 16/18722 0.577849005104531 0.793591471991899 SMS 1 GO:0006828 manganese ion transport 1/982 16/18722 0.577849005104531 0.793591471991899 SLC11A2 1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1/982 16/18722 0.577849005104531 0.793591471991899 BRCA2 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/982 16/18722 0.577849005104531 0.793591471991899 METTL3 1 GO:0009074 aromatic amino acid family catabolic process 1/982 16/18722 0.577849005104531 0.793591471991899 GSTZ1 1 GO:0010819 regulation of T cell chemotaxis 1/982 16/18722 0.577849005104531 0.793591471991899 CCL5 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/982 16/18722 0.577849005104531 0.793591471991899 P2RY6 1 GO:0030033 microvillus assembly 1/982 16/18722 0.577849005104531 0.793591471991899 KLF5 1 GO:0034138 toll-like receptor 3 signaling pathway 1/982 16/18722 0.577849005104531 0.793591471991899 COLEC12 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/982 16/18722 0.577849005104531 0.793591471991899 PPARG 1 GO:0035067 negative regulation of histone acetylation 1/982 16/18722 0.577849005104531 0.793591471991899 ZNF451 1 GO:0042481 regulation of odontogenesis 1/982 16/18722 0.577849005104531 0.793591471991899 SP6 1 GO:0042574 retinal metabolic process 1/982 16/18722 0.577849005104531 0.793591471991899 RDH10 1 GO:0042795 snRNA transcription by RNA polymerase II 1/982 16/18722 0.577849005104531 0.793591471991899 ELL 1 GO:0043923 positive regulation by host of viral transcription 1/982 16/18722 0.577849005104531 0.793591471991899 TAF11 1 GO:0044804 autophagy of nucleus 1/982 16/18722 0.577849005104531 0.793591471991899 WIPI2 1 GO:0044849 estrous cycle 1/982 16/18722 0.577849005104531 0.793591471991899 PTN 1 GO:0045722 positive regulation of gluconeogenesis 1/982 16/18722 0.577849005104531 0.793591471991899 DDB1 1 GO:0045779 negative regulation of bone resorption 1/982 16/18722 0.577849005104531 0.793591471991899 UBASH3B 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/982 16/18722 0.577849005104531 0.793591471991899 TRIM28 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/982 16/18722 0.577849005104531 0.793591471991899 NR2F6 1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 1/982 16/18722 0.577849005104531 0.793591471991899 SH3D19 1 GO:0055089 fatty acid homeostasis 1/982 16/18722 0.577849005104531 0.793591471991899 GPAM 1 GO:0060004 reflex 1/982 16/18722 0.577849005104531 0.793591471991899 AFG3L2 1 GO:0060330 regulation of response to interferon-gamma 1/982 16/18722 0.577849005104531 0.793591471991899 PPARG 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/982 16/18722 0.577849005104531 0.793591471991899 PPARG 1 GO:0070200 establishment of protein localization to telomere 1/982 16/18722 0.577849005104531 0.793591471991899 BRCA2 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/982 16/18722 0.577849005104531 0.793591471991899 CCL5 1 GO:0070365 hepatocyte differentiation 1/982 16/18722 0.577849005104531 0.793591471991899 KRT18 1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 1/982 16/18722 0.577849005104531 0.793591471991899 TRIT1 1 GO:0070571 negative regulation of neuron projection regeneration 1/982 16/18722 0.577849005104531 0.793591471991899 MAP4K4 1 GO:0071501 cellular response to sterol depletion 1/982 16/18722 0.577849005104531 0.793591471991899 INSIG1 1 GO:0071732 cellular response to nitric oxide 1/982 16/18722 0.577849005104531 0.793591471991899 CCNA2 1 GO:0072109 glomerular mesangium development 1/982 16/18722 0.577849005104531 0.793591471991899 BMP7 1 GO:0072283 metanephric renal vesicle morphogenesis 1/982 16/18722 0.577849005104531 0.793591471991899 KIF26B 1 GO:0080009 mRNA methylation 1/982 16/18722 0.577849005104531 0.793591471991899 METTL3 1 GO:0090231 regulation of spindle checkpoint 1/982 16/18722 0.577849005104531 0.793591471991899 LCMT1 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/982 16/18722 0.577849005104531 0.793591471991899 LCMT1 1 GO:0090336 positive regulation of brown fat cell differentiation 1/982 16/18722 0.577849005104531 0.793591471991899 BMP7 1 GO:0097428 protein maturation by iron-sulfur cluster transfer 1/982 16/18722 0.577849005104531 0.793591471991899 MAGEF1 1 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 1/982 16/18722 0.577849005104531 0.793591471991899 NSG1 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/982 16/18722 0.577849005104531 0.793591471991899 ATP2B1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/982 16/18722 0.577849005104531 0.793591471991899 SEMA6A 1 GO:1901163 regulation of trophoblast cell migration 1/982 16/18722 0.577849005104531 0.793591471991899 GJA1 1 GO:1901201 regulation of extracellular matrix assembly 1/982 16/18722 0.577849005104531 0.793591471991899 DAG1 1 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/982 16/18722 0.577849005104531 0.793591471991899 TRIAP1 1 GO:1902570 protein localization to nucleolus 1/982 16/18722 0.577849005104531 0.793591471991899 RPF2 1 GO:1903504 regulation of mitotic spindle checkpoint 1/982 16/18722 0.577849005104531 0.793591471991899 LCMT1 1 GO:1904683 regulation of metalloendopeptidase activity 1/982 16/18722 0.577849005104531 0.793591471991899 TIMP3 1 GO:1904862 inhibitory synapse assembly 1/982 16/18722 0.577849005104531 0.793591471991899 PLXNB1 1 GO:1904948 midbrain dopaminergic neuron differentiation 1/982 16/18722 0.577849005104531 0.793591471991899 LRP6 1 GO:1905153 regulation of membrane invagination 1/982 16/18722 0.577849005104531 0.793591471991899 RAB31 1 GO:2000765 regulation of cytoplasmic translation 1/982 16/18722 0.577849005104531 0.793591471991899 DHX9 1 GO:2000846 regulation of corticosteroid hormone secretion 1/982 16/18722 0.577849005104531 0.793591471991899 C1QTNF1 1 GO:2001212 regulation of vasculogenesis 1/982 16/18722 0.577849005104531 0.793591471991899 ADM 1 GO:2001224 positive regulation of neuron migration 1/982 16/18722 0.577849005104531 0.793591471991899 SEMA6A 1 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/982 16/18722 0.577849005104531 0.793591471991899 GSN 1 GO:0048285 organelle fission 25/982 488/18722 0.578322353407071 0.794032481013763 OBSL1/LRP5/BMP7/PPARG/INF2/ASPM/MIEF1/CENPF/SMC2/P3H4/CHTF8/ZWINT/SPDL1/EPS8/RACGAP1/PINK1/SLC25A46/TOP2A/BRCA2/TPX2/KMT5A/CCNE1/KIF4A/LCMT1/RAD50 25 GO:0006887 exocytosis 18/982 352/18722 0.578901022446067 0.794563215928869 SCIN/SYT7/FER/TRPV6/MICAL3/PRSS12/SYNJ1/SNX4/SCAMP1/EXPH5/RAB13/CCL5/RAB31/RABEPK/EXOC2/PDPK1/ANXA3/NAPA 18 GO:0000380 alternative mRNA splicing, via spliceosome 4/982 77/18722 0.579898925746562 0.794563215928869 ESRP2/MBNL3/MBNL2/DHX9 4 GO:1901983 regulation of protein acetylation 4/982 77/18722 0.579898925746562 0.794563215928869 ISL1/SOX4/ZNF451/RPS6KA4 4 GO:1901216 positive regulation of neuron death 5/982 97/18722 0.580317181577807 0.794563215928869 NF1/TFAP2A/NUPR1/GRN/BAD 5 GO:0006611 protein export from nucleus 3/982 57/18722 0.580841553362113 0.794563215928869 PTPN14/MDM2/TCF7L2 3 GO:0006695 cholesterol biosynthetic process 3/982 57/18722 0.580841553362113 0.794563215928869 DHCR24/MVK/INSIG1 3 GO:0006754 ATP biosynthetic process 3/982 57/18722 0.580841553362113 0.794563215928869 SLC25A13/TMSB4X/PINK1 3 GO:0006949 syncytium formation 3/982 57/18722 0.580841553362113 0.794563215928869 ERVW-1/MYOF/ERVH48-1 3 GO:0030219 megakaryocyte differentiation 3/982 57/18722 0.580841553362113 0.794563215928869 SCIN/RCOR1/UBA5 3 GO:0051155 positive regulation of striated muscle cell differentiation 3/982 57/18722 0.580841553362113 0.794563215928869 PARP2/MMP14/MORF4L2 3 GO:0051205 protein insertion into membrane 3/982 57/18722 0.580841553362113 0.794563215928869 EGFR/TRAM2/REEP1 3 GO:0051289 protein homotetramerization 3/982 57/18722 0.580841553362113 0.794563215928869 B2M/TK1/CBY1 3 GO:0060760 positive regulation of response to cytokine stimulus 3/982 57/18722 0.580841553362113 0.794563215928869 AGPAT1/TRIM6/DHX9 3 GO:1902653 secondary alcohol biosynthetic process 3/982 57/18722 0.580841553362113 0.794563215928869 DHCR24/MVK/INSIG1 3 GO:0071674 mononuclear cell migration 10/982 196/18722 0.581645391506814 0.79545421135279 CD200/APP/FLT1/WASL/PTK2/EPS8/CCL5/LGMN/CREB3/F11R 10 GO:0051924 regulation of calcium ion transport 13/982 255/18722 0.58243528716168 0.796325677021055 GJA1/UBASH3B/CHD7/CAMK2G/WFS1/ATP2B1/TSPAN13/P2RY6/CCL5/CYBA/EHD3/TRIM27/PDPK1 13 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/982 37/18722 0.585024565067389 0.796525223542548 HEATR1/DCAF13 2 GO:0003176 aortic valve development 2/982 37/18722 0.585024565067389 0.796525223542548 EFNA1/RBPJ 2 GO:0006904 vesicle docking involved in exocytosis 2/982 37/18722 0.585024565067389 0.796525223542548 RAB13/RABEPK 2 GO:0014904 myotube cell development 2/982 37/18722 0.585024565067389 0.796525223542548 BIN3/FBXO22 2 GO:0031646 positive regulation of nervous system process 2/982 37/18722 0.585024565067389 0.796525223542548 DAG1/PARD3 2 GO:0033120 positive regulation of RNA splicing 2/982 37/18722 0.585024565067389 0.796525223542548 SLC38A2/HNRNPLL 2 GO:0042401 cellular biogenic amine biosynthetic process 2/982 37/18722 0.585024565067389 0.796525223542548 SMS/AZIN1 2 GO:0043029 T cell homeostasis 2/982 37/18722 0.585024565067389 0.796525223542548 GPAM/SLC39A3 2 GO:0045616 regulation of keratinocyte differentiation 2/982 37/18722 0.585024565067389 0.796525223542548 NCOA3/FOXC1 2 GO:0046473 phosphatidic acid metabolic process 2/982 37/18722 0.585024565067389 0.796525223542548 GPAM/AGPAT1 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/982 37/18722 0.585024565067389 0.796525223542548 IGF1R/CRIM1 2 GO:0051567 histone H3-K9 methylation 2/982 37/18722 0.585024565067389 0.796525223542548 LMNA/DNMT1 2 GO:0051954 positive regulation of amine transport 2/982 37/18722 0.585024565067389 0.796525223542548 PINK1/ITGB1 2 GO:0071985 multivesicular body sorting pathway 2/982 37/18722 0.585024565067389 0.796525223542548 EXPH5/LEPROT 2 GO:1902745 positive regulation of lamellipodium organization 2/982 37/18722 0.585024565067389 0.796525223542548 CYFIP1/NCKAP1 2 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 2/982 37/18722 0.585024565067389 0.796525223542548 PKIB/ATR 2 GO:0051302 regulation of cell division 9/982 177/18722 0.586309042874265 0.798065753557454 FGFR2/PTN/ASPM/NCOA3/RACGAP1/PDGFA/PLK2/BRCA2/PGF 9 GO:0018105 peptidyl-serine phosphorylation 16/982 315/18722 0.589256663336141 0.798584993039468 EGFR/APP/TFRC/LATS2/PRKCI/TRIM6/HDAC6/BCAR3/MAP3K13/PINK1/ATR/PLK2/RICTOR/TOP1/RPS6KA4/PDPK1 16 GO:0043502 regulation of muscle adaptation 5/982 98/18722 0.589511353900065 0.798584993039468 DAG1/PARP2/IL6ST/CAMK2G/LMNA 5 GO:0051282 regulation of sequestering of calcium ion 6/982 118/18722 0.589791110970573 0.798584993039468 MCOLN3/UBASH3B/CHD7/P2RY6/CYBA/PDPK1 6 GO:0032371 regulation of sterol transport 4/982 78/18722 0.590194210755577 0.798584993039468 LRP1/PPARG/RXRA/ANXA2 4 GO:0032374 regulation of cholesterol transport 4/982 78/18722 0.590194210755577 0.798584993039468 LRP1/PPARG/RXRA/ANXA2 4 GO:0000724 double-strand break repair via homologous recombination 7/982 138/18722 0.59061646068836 0.798584993039468 POLQ/MCM2/FEN1/RMI2/MAGEF1/BRCA2/WDR48 7 GO:0018393 internal peptidyl-lysine acetylation 8/982 158/18722 0.591771149001892 0.798584993039468 ISL1/MAP3K7/NCOA3/MORF4L2/ZNF451/BRCA2/RPS6KA4/MED24 8 GO:0043488 regulation of mRNA stability 8/982 158/18722 0.591771149001892 0.798584993039468 AXIN2/PUM1/TARDBP/YTHDF2/PUM2/DHX9/METTL3/VIM 8 GO:0034340 response to type I interferon 3/982 58/18722 0.592755361889789 0.798584993039468 TRIM6/YTHDF2/METTL3 3 GO:0044380 protein localization to cytoskeleton 3/982 58/18722 0.592755361889789 0.798584993039468 FAM83H/HOOK3/GOLGB1 3 GO:2000649 regulation of sodium ion transmembrane transporter activity 3/982 58/18722 0.592755361889789 0.798584993039468 WNK2/FXYD3/ANK3 3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 3/982 58/18722 0.592755361889789 0.798584993039468 SIAH1/NUPR1/BAD 3 GO:0009266 response to temperature stimulus 9/982 178/18722 0.593132654445554 0.798584993039468 ADRB1/SLC52A3/EIF2AK4/ADM/DNAJB4/ATP2B1/ACADVL/ATR/NR2F6 9 GO:0051783 regulation of nuclear division 7/982 139/18722 0.598295896699336 0.798584993039468 OBSL1/LRP5/BMP7/CENPF/ZWINT/SPDL1/LCMT1 7 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 5/982 99/18722 0.598593924535956 0.798584993039468 TRIAP1/NUPR1/BRCA2/USP47/BAD 5 GO:0051153 regulation of striated muscle cell differentiation 5/982 99/18722 0.598593924535956 0.798584993039468 BHLHE41/PARP2/MMP14/MORF4L2/FBXO22 5 GO:0006882 cellular zinc ion homeostasis 2/982 38/18722 0.599673708755379 0.798584993039468 SLC39A10/SLC39A7 2 GO:0007007 inner mitochondrial membrane organization 2/982 38/18722 0.599673708755379 0.798584993039468 PINK1/AFG3L2 2 GO:0009309 amine biosynthetic process 2/982 38/18722 0.599673708755379 0.798584993039468 SMS/AZIN1 2 GO:0010613 positive regulation of cardiac muscle hypertrophy 2/982 38/18722 0.599673708755379 0.798584993039468 PARP2/IL6ST 2 GO:0010719 negative regulation of epithelial to mesenchymal transition 2/982 38/18722 0.599673708755379 0.798584993039468 EFNA1/ZNF750 2 GO:0010742 macrophage derived foam cell differentiation 2/982 38/18722 0.599673708755379 0.798584993039468 ITGAV/PPARG 2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2/982 38/18722 0.599673708755379 0.798584993039468 ISL1/DAB2 2 GO:0035337 fatty-acyl-CoA metabolic process 2/982 38/18722 0.599673708755379 0.798584993039468 SLC25A1/HSD17B12 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/982 38/18722 0.599673708755379 0.798584993039468 ADM/DNMT1 2 GO:0046633 alpha-beta T cell proliferation 2/982 38/18722 0.599673708755379 0.798584993039468 HLA-A/HLA-E 2 GO:0046676 negative regulation of insulin secretion 2/982 38/18722 0.599673708755379 0.798584993039468 MAP4K4/ENY2 2 GO:0048246 macrophage chemotaxis 2/982 38/18722 0.599673708755379 0.798584993039468 PTK2/CCL5 2 GO:0072524 pyridine-containing compound metabolic process 2/982 38/18722 0.599673708755379 0.798584993039468 PSAT1/QPRT 2 GO:0090077 foam cell differentiation 2/982 38/18722 0.599673708755379 0.798584993039468 ITGAV/PPARG 2 GO:1901186 positive regulation of ERBB signaling pathway 2/982 38/18722 0.599673708755379 0.798584993039468 BCAR3/RBPJ 2 GO:0000076 DNA replication checkpoint signaling 1/982 17/18722 0.600010465437438 0.798584993039468 TOPBP1 1 GO:0000097 sulfur amino acid biosynthetic process 1/982 17/18722 0.600010465437438 0.798584993039468 CDO1 1 GO:0001780 neutrophil homeostasis 1/982 17/18722 0.600010465437438 0.798584993039468 JAM3 1 GO:0001829 trophectodermal cell differentiation 1/982 17/18722 0.600010465437438 0.798584993039468 YAP1 1 GO:0002031 G protein-coupled receptor internalization 1/982 17/18722 0.600010465437438 0.798584993039468 ADM 1 GO:0003184 pulmonary valve morphogenesis 1/982 17/18722 0.600010465437438 0.798584993039468 GJA5 1 GO:0006390 mitochondrial transcription 1/982 17/18722 0.600010465437438 0.798584993039468 TFAM 1 GO:0006474 N-terminal protein amino acid acetylation 1/982 17/18722 0.600010465437438 0.798584993039468 SOX4 1 GO:0006577 amino-acid betaine metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 ALDH7A1 1 GO:0006895 Golgi to endosome transport 1/982 17/18722 0.600010465437438 0.798584993039468 KIF16B 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 ADK 1 GO:0010224 response to UV-B 1/982 17/18722 0.600010465437438 0.798584993039468 MME 1 GO:0010470 regulation of gastrulation 1/982 17/18722 0.600010465437438 0.798584993039468 DAG1 1 GO:0010566 regulation of ketone biosynthetic process 1/982 17/18722 0.600010465437438 0.798584993039468 ADM 1 GO:0010612 regulation of cardiac muscle adaptation 1/982 17/18722 0.600010465437438 0.798584993039468 LMNA 1 GO:0010831 positive regulation of myotube differentiation 1/982 17/18722 0.600010465437438 0.798584993039468 MMP14 1 GO:0014856 skeletal muscle cell proliferation 1/982 17/18722 0.600010465437438 0.798584993039468 PPARD 1 GO:0020027 hemoglobin metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 ALAS1 1 GO:0021513 spinal cord dorsal/ventral patterning 1/982 17/18722 0.600010465437438 0.798584993039468 GLI3 1 GO:0030322 stabilization of membrane potential 1/982 17/18722 0.600010465437438 0.798584993039468 KCNN4 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/982 17/18722 0.600010465437438 0.798584993039468 LEPROT 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/982 17/18722 0.600010465437438 0.798584993039468 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/982 17/18722 0.600010465437438 0.798584993039468 ISL1 1 GO:0036065 fucosylation 1/982 17/18722 0.600010465437438 0.798584993039468 FUT8 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/982 17/18722 0.600010465437438 0.798584993039468 SYNJ1 1 GO:0036166 phenotypic switching 1/982 17/18722 0.600010465437438 0.798584993039468 DNMT1 1 GO:0042053 regulation of dopamine metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 COMT 1 GO:0042069 regulation of catecholamine metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 COMT 1 GO:0042448 progesterone metabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 ADM 1 GO:0042772 DNA damage response, signal transduction resulting in transcription 1/982 17/18722 0.600010465437438 0.798584993039468 BRCA2 1 GO:0043649 dicarboxylic acid catabolic process 1/982 17/18722 0.600010465437438 0.798584993039468 QPRT 1 GO:0043968 histone H2A acetylation 1/982 17/18722 0.600010465437438 0.798584993039468 MORF4L2 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/982 17/18722 0.600010465437438 0.798584993039468 FAT1 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/982 17/18722 0.600010465437438 0.798584993039468 CD46 1 GO:0046855 inositol phosphate dephosphorylation 1/982 17/18722 0.600010465437438 0.798584993039468 SYNJ1 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/982 17/18722 0.600010465437438 0.798584993039468 SYT7 1 GO:0051580 regulation of neurotransmitter uptake 1/982 17/18722 0.600010465437438 0.798584993039468 ITGB1 1 GO:0051797 regulation of hair follicle development 1/982 17/18722 0.600010465437438 0.798584993039468 FERMT1 1 GO:0055003 cardiac myofibril assembly 1/982 17/18722 0.600010465437438 0.798584993039468 OBSL1 1 GO:0055064 chloride ion homeostasis 1/982 17/18722 0.600010465437438 0.798584993039468 ATP6V1B1 1 GO:0055083 monovalent inorganic anion homeostasis 1/982 17/18722 0.600010465437438 0.798584993039468 ATP6V1B1 1 GO:0055119 relaxation of cardiac muscle 1/982 17/18722 0.600010465437438 0.798584993039468 GSN 1 GO:0060263 regulation of respiratory burst 1/982 17/18722 0.600010465437438 0.798584993039468 GRN 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/982 17/18722 0.600010465437438 0.798584993039468 TARDBP 1 GO:0070206 protein trimerization 1/982 17/18722 0.600010465437438 0.798584993039468 SLC1A5 1 GO:0070593 dendrite self-avoidance 1/982 17/18722 0.600010465437438 0.798584993039468 BSG 1 GO:0072673 lamellipodium morphogenesis 1/982 17/18722 0.600010465437438 0.798584993039468 KANK1 1 GO:0090713 immunological memory process 1/982 17/18722 0.600010465437438 0.798584993039468 CD46 1 GO:1900034 regulation of cellular response to heat 1/982 17/18722 0.600010465437438 0.798584993039468 ATR 1 GO:1901550 regulation of endothelial cell development 1/982 17/18722 0.600010465437438 0.798584993039468 F11R 1 GO:1902358 sulfate transmembrane transport 1/982 17/18722 0.600010465437438 0.798584993039468 SLC26A2 1 GO:1903140 regulation of establishment of endothelial barrier 1/982 17/18722 0.600010465437438 0.798584993039468 F11R 1 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 1/982 17/18722 0.600010465437438 0.798584993039468 LMNA 1 GO:1903540 establishment of protein localization to postsynaptic membrane 1/982 17/18722 0.600010465437438 0.798584993039468 NSG1 1 GO:1903830 magnesium ion transmembrane transport 1/982 17/18722 0.600010465437438 0.798584993039468 TUSC3 1 GO:1904355 positive regulation of telomere capping 1/982 17/18722 0.600010465437438 0.798584993039468 PKIB 1 GO:0000245 spliceosomal complex assembly 4/982 79/18722 0.600339649779822 0.798615560635438 USP39/PRPF39/SRPK1/DDX1 4 GO:0001895 retina homeostasis 4/982 79/18722 0.600339649779822 0.798615560635438 SLC2A1/B2M/NPHP3/PRDX1 4 GO:0060271 cilium assembly 17/982 337/18722 0.601369258157629 0.799781246953134 LAMA5/YAP1/LIMK2/GALNT11/FNBP1L/HDAC6/IFT74/NPHP3/RILPL1/AHI1/TCTN3/GSN/RAB17/DYNLL2/EHD3/SDCCAG8/CEP135 17 GO:0021885 forebrain cell migration 3/982 59/18722 0.604447418810957 0.803260569813491 LAMB1/ADGRG1/GLI3 3 GO:0048278 vesicle docking 3/982 59/18722 0.604447418810957 0.803260569813491 RAB13/CLN3/RABEPK 3 GO:0051055 negative regulation of lipid biosynthetic process 3/982 59/18722 0.604447418810957 0.803260569813491 ACADVL/PDGFA/INSIG1 3 GO:0000725 recombinational repair 7/982 140/18722 0.605900677279409 0.804781750111892 POLQ/MCM2/FEN1/RMI2/MAGEF1/BRCA2/WDR48 7 GO:0046165 alcohol biosynthetic process 7/982 140/18722 0.605900677279409 0.804781750111892 ISYNA1/DHCR24/MVK/P2RY6/INSIG1/AKR1B1/SPTLC3 7 GO:0006475 internal protein amino acid acetylation 8/982 160/18722 0.606072606118945 0.804805171465482 ISL1/MAP3K7/NCOA3/MORF4L2/ZNF451/BRCA2/RPS6KA4/MED24 8 GO:0018209 peptidyl-serine modification 17/982 338/18722 0.606301107187511 0.804903684166469 EGFR/APP/PARP2/TFRC/LATS2/PRKCI/TRIM6/HDAC6/BCAR3/MAP3K13/PINK1/ATR/PLK2/RICTOR/TOP1/RPS6KA4/PDPK1 17 GO:0042254 ribosome biogenesis 15/982 299/18722 0.60812917192465 0.807125129964116 CHD7/HEATR3/MAK16/NPM3/REXO4/ERI2/RPF2/YTHDF2/ABCE1/RPL10/WDR43/LSG1/HEATR1/MPHOSPH10/DCAF13 15 GO:0031503 protein-containing complex localization 11/982 220/18722 0.608400845988511 0.807280288139423 DAG1/HRAS/NSG1/WASL/IFT74/ABCE1/ZDHHC3/ATR/BIRC5/LSG1/ENY2 11 GO:0051052 regulation of DNA metabolic process 18/982 359/18722 0.612757255985911 0.807978629988317 GJA1/EGFR/TFRC/POLQ/CHTF8/BRCC3/AXIN2/WRNIP1/RMI2/MAGEF1/PKIB/ATR/DHX9/WDR48/TRIM28/RAD50/DFFA/ANXA3 18 GO:0006473 protein acetylation 10/982 201/18722 0.613739862252209 0.807978629988317 ISL1/SOX4/MAP3K7/NCOA3/MORF4L2/ZNF451/NUPR1/BRCA2/RPS6KA4/MED24 10 GO:0002347 response to tumor cell 2/982 39/18722 0.613929642021567 0.807978629988317 RBMS3/HLA-A 2 GO:0007618 mating 2/982 39/18722 0.613929642021567 0.807978629988317 SLC6A4/APP 2 GO:0014742 positive regulation of muscle hypertrophy 2/982 39/18722 0.613929642021567 0.807978629988317 PARP2/IL6ST 2 GO:0016233 telomere capping 2/982 39/18722 0.613929642021567 0.807978629988317 PKIB/RAD50 2 GO:0016572 histone phosphorylation 2/982 39/18722 0.613929642021567 0.807978629988317 RPS6KA4/CCNA2 2 GO:0017158 regulation of calcium ion-dependent exocytosis 2/982 39/18722 0.613929642021567 0.807978629988317 SYT7/TRPV6 2 GO:0031507 heterochromatin assembly 2/982 39/18722 0.613929642021567 0.807978629988317 TRIM28/DNMT1 2 GO:0032506 cytokinetic process 2/982 39/18722 0.613929642021567 0.807978629988317 RACGAP1/BIN3 2 GO:0036297 interstrand cross-link repair 2/982 39/18722 0.613929642021567 0.807978629988317 FANCE/ATR 2 GO:0045823 positive regulation of heart contraction 2/982 39/18722 0.613929642021567 0.807978629988317 ADRB1/ADM 2 GO:0046461 neutral lipid catabolic process 2/982 39/18722 0.613929642021567 0.807978629988317 ABHD12/PNPLA2 2 GO:0046464 acylglycerol catabolic process 2/982 39/18722 0.613929642021567 0.807978629988317 ABHD12/PNPLA2 2 GO:0051084 'de novo' posttranslational protein folding 2/982 39/18722 0.613929642021567 0.807978629988317 DNAJB4/BAG1 2 GO:0090207 regulation of triglyceride metabolic process 2/982 39/18722 0.613929642021567 0.807978629988317 LDLR/PNPLA2 2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 2/982 39/18722 0.613929642021567 0.807978629988317 P2RY6/EHD3 2 GO:0002224 toll-like receptor signaling pathway 6/982 121/18722 0.614400533580072 0.807978629988317 LGR4/COLEC12/MAP3K7/CYBA/PDPK1/BCL10 6 GO:0002712 regulation of B cell mediated immunity 3/982 60/18722 0.615914875991025 0.807978629988317 TFRC/CD46/HLA-E 3 GO:0002889 regulation of immunoglobulin mediated immune response 3/982 60/18722 0.615914875991025 0.807978629988317 TFRC/CD46/HLA-E 3 GO:0006081 cellular aldehyde metabolic process 3/982 60/18722 0.615914875991025 0.807978629988317 RDH10/ALDH7A1/IDH1 3 GO:0006289 nucleotide-excision repair 3/982 60/18722 0.615914875991025 0.807978629988317 DDB1/BRCA2/RAD23B 3 GO:0051965 positive regulation of synapse assembly 3/982 60/18722 0.615914875991025 0.807978629988317 VSTM5/TPBG/DLG5 3 GO:0050804 modulation of chemical synaptic transmission 22/982 439/18722 0.618950241447949 0.807978629988317 CDH1/EGFR/SLC6A4/APP/SHANK2/SYT7/MME/EIF2AK4/PTN/SLC1A3/CYFIP1/PPP1R9A/GNAI1/HRAS/NSG1/CLN3/PACSIN2/PINK1/LGMN/ITGB1/ZDHHC3/PLK2 22 GO:0060401 cytosolic calcium ion transport 9/982 182/18722 0.619876074606418 0.807978629988317 MCOLN3/UBASH3B/CHD7/TRPV6/ATP2B1/P2RY6/CYBA/AFG3L2/PDPK1 9 GO:0051149 positive regulation of muscle cell differentiation 4/982 81/18722 0.620169681742242 0.807978629988317 PARP2/MMP14/MORF4L2/MDM2 4 GO:0097553 calcium ion transmembrane import into cytosol 7/982 142/18722 0.620879483307255 0.807978629988317 MCOLN3/UBASH3B/CHD7/TRPV6/P2RY6/CYBA/PDPK1 7 GO:0000712 resolution of meiotic recombination intermediates 1/982 18/18722 0.621009648700759 0.807978629988317 TOP2A 1 GO:0002076 osteoblast development 1/982 18/18722 0.621009648700759 0.807978629988317 LRP5 1 GO:0002223 stimulatory C-type lectin receptor signaling pathway 1/982 18/18722 0.621009648700759 0.807978629988317 MAP3K7 1 GO:0002283 neutrophil activation involved in immune response 1/982 18/18722 0.621009648700759 0.807978629988317 ANXA3 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/982 18/18722 0.621009648700759 0.807978629988317 B2M 1 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 1/982 18/18722 0.621009648700759 0.807978629988317 CD46 1 GO:0003417 growth plate cartilage development 1/982 18/18722 0.621009648700759 0.807978629988317 TSKU 1 GO:0006085 acetyl-CoA biosynthetic process 1/982 18/18722 0.621009648700759 0.807978629988317 ACSS1 1 GO:0006103 2-oxoglutarate metabolic process 1/982 18/18722 0.621009648700759 0.807978629988317 IDH1 1 GO:0006415 translational termination 1/982 18/18722 0.621009648700759 0.807978629988317 ABCE1 1 GO:0006991 response to sterol depletion 1/982 18/18722 0.621009648700759 0.807978629988317 INSIG1 1 GO:0007549 dosage compensation 1/982 18/18722 0.621009648700759 0.807978629988317 METTL3 1 GO:0015693 magnesium ion transport 1/982 18/18722 0.621009648700759 0.807978629988317 TUSC3 1 GO:0015732 prostaglandin transport 1/982 18/18722 0.621009648700759 0.807978629988317 PTGES 1 GO:0021511 spinal cord patterning 1/982 18/18722 0.621009648700759 0.807978629988317 GLI3 1 GO:0030728 ovulation 1/982 18/18722 0.621009648700759 0.807978629988317 ADAMTS1 1 GO:0032095 regulation of response to food 1/982 18/18722 0.621009648700759 0.807978629988317 NENF 1 GO:0032305 positive regulation of icosanoid secretion 1/982 18/18722 0.621009648700759 0.807978629988317 PTGES 1 GO:0032634 interleukin-5 production 1/982 18/18722 0.621009648700759 0.807978629988317 TNFRSF21 1 GO:0032674 regulation of interleukin-5 production 1/982 18/18722 0.621009648700759 0.807978629988317 TNFRSF21 1 GO:0033189 response to vitamin A 1/982 18/18722 0.621009648700759 0.807978629988317 PPARD 1 GO:0034134 toll-like receptor 2 signaling pathway 1/982 18/18722 0.621009648700759 0.807978629988317 CYBA 1 GO:0035930 corticosteroid hormone secretion 1/982 18/18722 0.621009648700759 0.807978629988317 C1QTNF1 1 GO:0036499 PERK-mediated unfolded protein response 1/982 18/18722 0.621009648700759 0.807978629988317 TMEM33 1 GO:0036507 protein demannosylation 1/982 18/18722 0.621009648700759 0.807978629988317 UGGT2 1 GO:0036508 protein alpha-1,2-demannosylation 1/982 18/18722 0.621009648700759 0.807978629988317 UGGT2 1 GO:0042136 neurotransmitter biosynthetic process 1/982 18/18722 0.621009648700759 0.807978629988317 SLC6A4 1 GO:0045116 protein neddylation 1/982 18/18722 0.621009648700759 0.807978629988317 EPAS1 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/982 18/18722 0.621009648700759 0.807978629988317 ADRB1 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/982 18/18722 0.621009648700759 0.807978629988317 SYT7 1 GO:0046112 nucleobase biosynthetic process 1/982 18/18722 0.621009648700759 0.807978629988317 PPAT 1 GO:0046838 phosphorylated carbohydrate dephosphorylation 1/982 18/18722 0.621009648700759 0.807978629988317 SYNJ1 1 GO:0046851 negative regulation of bone remodeling 1/982 18/18722 0.621009648700759 0.807978629988317 UBASH3B 1 GO:0050665 hydrogen peroxide biosynthetic process 1/982 18/18722 0.621009648700759 0.807978629988317 CYBA 1 GO:0051782 negative regulation of cell division 1/982 18/18722 0.621009648700759 0.807978629988317 ASPM 1 GO:0060546 negative regulation of necroptotic process 1/982 18/18722 0.621009648700759 0.807978629988317 SLC25A4 1 GO:0060716 labyrinthine layer blood vessel development 1/982 18/18722 0.621009648700759 0.807978629988317 RBPJ 1 GO:0060749 mammary gland alveolus development 1/982 18/18722 0.621009648700759 0.807978629988317 CCND1 1 GO:0061377 mammary gland lobule development 1/982 18/18722 0.621009648700759 0.807978629988317 CCND1 1 GO:0071318 cellular response to ATP 1/982 18/18722 0.621009648700759 0.807978629988317 HSP90B1 1 GO:0071800 podosome assembly 1/982 18/18722 0.621009648700759 0.807978629988317 GSN 1 GO:0072079 nephron tubule formation 1/982 18/18722 0.621009648700759 0.807978629988317 IRX2 1 GO:0072189 ureter development 1/982 18/18722 0.621009648700759 0.807978629988317 NPHP3 1 GO:0080182 histone H3-K4 trimethylation 1/982 18/18722 0.621009648700759 0.807978629988317 TET2 1 GO:0098877 neurotransmitter receptor transport to plasma membrane 1/982 18/18722 0.621009648700759 0.807978629988317 NSG1 1 GO:0150078 positive regulation of neuroinflammatory response 1/982 18/18722 0.621009648700759 0.807978629988317 NUPR1 1 GO:1902170 cellular response to reactive nitrogen species 1/982 18/18722 0.621009648700759 0.807978629988317 CCNA2 1 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1/982 18/18722 0.621009648700759 0.807978629988317 SEMA6A 1 GO:1990840 response to lectin 1/982 18/18722 0.621009648700759 0.807978629988317 MAP3K7 1 GO:1990858 cellular response to lectin 1/982 18/18722 0.621009648700759 0.807978629988317 MAP3K7 1 GO:2000641 regulation of early endosome to late endosome transport 1/982 18/18722 0.621009648700759 0.807978629988317 DAB2 1 GO:0051928 positive regulation of calcium ion transport 6/982 122/18722 0.622417558783133 0.809608475464544 WFS1/ATP2B1/P2RY6/CCL5/EHD3/PDPK1 6 GO:0099177 regulation of trans-synaptic signaling 22/982 440/18722 0.623226691105109 0.810458843381762 CDH1/EGFR/SLC6A4/APP/SHANK2/SYT7/MME/EIF2AK4/PTN/SLC1A3/CYFIP1/PPP1R9A/GNAI1/HRAS/NSG1/CLN3/PACSIN2/PINK1/LGMN/ITGB1/ZDHHC3/PLK2 22 GO:0006672 ceramide metabolic process 5/982 102/18722 0.625147789730455 0.812147165936252 PLPP3/ITGB8/DEGS1/SPTLC3/NEU1 5 GO:0010522 regulation of calcium ion transport into cytosol 5/982 102/18722 0.625147789730455 0.812147165936252 UBASH3B/CHD7/P2RY6/CYBA/PDPK1 5 GO:0034308 primary alcohol metabolic process 5/982 102/18722 0.625147789730455 0.812147165936252 ACSS1/RDH10/RDH14/PNPLA2/AKR1B1 5 GO:1902106 negative regulation of leukocyte differentiation 5/982 102/18722 0.625147789730455 0.812147165936252 FBN1/UBASH3B/GLI3/CDK6/NME1 5 GO:0050657 nucleic acid transport 8/982 163/18722 0.627034407347065 0.812951762732787 IGF2BP3/NCBP3/DHX9/NUP153/RANBP2/UPF3A/TST/ENY2 8 GO:0050658 RNA transport 8/982 163/18722 0.627034407347065 0.812951762732787 IGF2BP3/NCBP3/DHX9/NUP153/RANBP2/UPF3A/TST/ENY2 8 GO:0043966 histone H3 acetylation 3/982 61/18722 0.627155441106666 0.812951762732787 MAP3K7/ZNF451/BRCA2 3 GO:0002714 positive regulation of B cell mediated immunity 2/982 40/18722 0.627793270760672 0.812951762732787 TFRC/HLA-E 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/982 40/18722 0.627793270760672 0.812951762732787 TFRC/HLA-E 2 GO:0009394 2'-deoxyribonucleotide metabolic process 2/982 40/18722 0.627793270760672 0.812951762732787 DTYMK/ADK 2 GO:0031297 replication fork processing 2/982 40/18722 0.627793270760672 0.812951762732787 ATR/BRCA2 2 GO:0032892 positive regulation of organic acid transport 2/982 40/18722 0.627793270760672 0.812951762732787 PTGES/ITGB1 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/982 40/18722 0.627793270760672 0.812951762732787 LGR4/PDPK1 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/982 40/18722 0.627793270760672 0.812951762732787 P2RY6/PDPK1 2 GO:0055069 zinc ion homeostasis 2/982 40/18722 0.627793270760672 0.812951762732787 SLC39A10/SLC39A7 2 GO:0070266 necroptotic process 2/982 40/18722 0.627793270760672 0.812951762732787 SPATA2/SLC25A4 2 GO:0097352 autophagosome maturation 2/982 40/18722 0.627793270760672 0.812951762732787 CLN3/PHF23 2 GO:0002237 response to molecule of bacterial origin 18/982 363/18722 0.631550491635741 0.817614138588242 GJA1/FGFR2/FER/B2M/ALAD/ADM/GNG12/TRIM6/PTGES/COMT/CD24/SPARC/PPARD/CCL5/GSTP1/VIM/ASS1/BCL10 18 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 13/982 264/18722 0.632688084113238 0.818210859831118 EGFR/APP/ISL1/NRP1/IL6ST/EFNA5/ERBB3/EFNA1/YES1/CD24/CCL5/PDGFA/RICTOR 13 GO:0032760 positive regulation of tumor necrosis factor production 5/982 103/18722 0.633760734343661 0.818210859831118 APP/ISL1/HLA-E/CYBA/DHX9 5 GO:0002700 regulation of production of molecular mediator of immune response 8/982 164/18722 0.633885475497242 0.818210859831118 TFRC/B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 8 GO:0022412 cellular process involved in reproduction in multicellular organism 19/982 384/18722 0.637104275275124 0.818210859831118 SPESP1/LGR5/ETV5/FOLR1/PTN/ASPM/JAM3/HOOK1/SMARCA2/YTHDF2/ITGB1/TOP2A/PRDX4/BRCA2/METTL3/SLIRP/SMAD5/FOXC1/SRPK1 19 GO:0006364 rRNA processing 11/982 225/18722 0.638085899207316 0.818210859831118 CHD7/MAK16/NPM3/REXO4/ERI2/RPF2/YTHDF2/WDR43/HEATR1/MPHOSPH10/DCAF13 11 GO:0001909 leukocyte mediated cytotoxicity 6/982 124/18722 0.638161874148938 0.818210859831118 CADM1/B2M/HLA-B/HLA-A/HLA-E/PRDX1 6 GO:0002260 lymphocyte homeostasis 3/982 62/18722 0.638167345763128 0.818210859831118 GPAM/SLC39A3/BCL10 3 GO:0007062 sister chromatid cohesion 3/982 62/18722 0.638167345763128 0.818210859831118 CHTF8/AXIN2/FEN1 3 GO:0010573 vascular endothelial growth factor production 3/982 62/18722 0.638167345763128 0.818210859831118 ISL1/IL6ST/ADGRG1 3 GO:0032731 positive regulation of interleukin-1 beta production 3/982 62/18722 0.638167345763128 0.818210859831118 APP/ISL1/NLRP2 3 GO:0045576 mast cell activation 3/982 62/18722 0.638167345763128 0.818210859831118 FER/SNX4/PDPK1 3 GO:0070265 necrotic cell death 3/982 62/18722 0.638167345763128 0.818210859831118 SPATA2/SLC25A4/NUPR1 3 GO:0002040 sprouting angiogenesis 9/982 185/18722 0.639320288669819 0.818210859831118 SEMA6A/NRP1/EPN2/EPHB4/TJP1/ITGB1/PLK2/PGF/PDPK1 9 GO:0051899 membrane depolarization 4/982 83/18722 0.639369585073144 0.818210859831118 GJA5/IFI6/ANK3/GCLM 4 GO:0002281 macrophage activation involved in immune response 1/982 19/18722 0.640907452645148 0.818210859831118 GRN 1 GO:0002396 MHC protein complex assembly 1/982 19/18722 0.640907452645148 0.818210859831118 B2M 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/982 19/18722 0.640907452645148 0.818210859831118 ADRB1 1 GO:0006144 purine nucleobase metabolic process 1/982 19/18722 0.640907452645148 0.818210859831118 PPAT 1 GO:0006309 apoptotic DNA fragmentation 1/982 19/18722 0.640907452645148 0.818210859831118 DFFA 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/982 19/18722 0.640907452645148 0.818210859831118 GNA11 1 GO:0007603 phototransduction, visible light 1/982 19/18722 0.640907452645148 0.818210859831118 GNA11 1 GO:0009301 snRNA transcription 1/982 19/18722 0.640907452645148 0.818210859831118 ELL 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/982 19/18722 0.640907452645148 0.818210859831118 STAMBP 1 GO:0019373 epoxygenase P450 pathway 1/982 19/18722 0.640907452645148 0.818210859831118 CYP2J2 1 GO:0030220 platelet formation 1/982 19/18722 0.640907452645148 0.818210859831118 ACTN1 1 GO:0031065 positive regulation of histone deacetylation 1/982 19/18722 0.640907452645148 0.818210859831118 PINK1 1 GO:0034501 protein localization to kinetochore 1/982 19/18722 0.640907452645148 0.818210859831118 SPDL1 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/982 19/18722 0.640907452645148 0.818210859831118 HSD17B12 1 GO:0036344 platelet morphogenesis 1/982 19/18722 0.640907452645148 0.818210859831118 ACTN1 1 GO:0036498 IRE1-mediated unfolded protein response 1/982 19/18722 0.640907452645148 0.818210859831118 TMEM33 1 GO:0038092 nodal signaling pathway 1/982 19/18722 0.640907452645148 0.818210859831118 DACT2 1 GO:0043652 engulfment of apoptotic cell 1/982 19/18722 0.640907452645148 0.818210859831118 RHOBTB1 1 GO:0044320 cellular response to leptin stimulus 1/982 19/18722 0.640907452645148 0.818210859831118 CCNA2 1 GO:0044827 modulation by host of viral genome replication 1/982 19/18722 0.640907452645148 0.818210859831118 EIF2AK4 1 GO:0045821 positive regulation of glycolytic process 1/982 19/18722 0.640907452645148 0.818210859831118 APP 1 GO:0045947 negative regulation of translational initiation 1/982 19/18722 0.640907452645148 0.818210859831118 EIF2AK4 1 GO:0046653 tetrahydrofolate metabolic process 1/982 19/18722 0.640907452645148 0.818210859831118 ATIC 1 GO:0046716 muscle cell cellular homeostasis 1/982 19/18722 0.640907452645148 0.818210859831118 GAA 1 GO:0048245 eosinophil chemotaxis 1/982 19/18722 0.640907452645148 0.818210859831118 CCL5 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/982 19/18722 0.640907452645148 0.818210859831118 NR2F6 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/982 19/18722 0.640907452645148 0.818210859831118 DNMT1 1 GO:0051957 positive regulation of amino acid transport 1/982 19/18722 0.640907452645148 0.818210859831118 ITGB1 1 GO:0060039 pericardium development 1/982 19/18722 0.640907452645148 0.818210859831118 BMP7 1 GO:0060065 uterus development 1/982 19/18722 0.640907452645148 0.818210859831118 KDM5B 1 GO:0061760 antifungal innate immune response 1/982 19/18722 0.640907452645148 0.818210859831118 BCL10 1 GO:0070989 oxidative demethylation 1/982 19/18722 0.640907452645148 0.818210859831118 TET2 1 GO:0071545 inositol phosphate catabolic process 1/982 19/18722 0.640907452645148 0.818210859831118 SYNJ1 1 GO:0072077 renal vesicle morphogenesis 1/982 19/18722 0.640907452645148 0.818210859831118 KIF26B 1 GO:0140131 positive regulation of lymphocyte chemotaxis 1/982 19/18722 0.640907452645148 0.818210859831118 CCL5 1 GO:1900221 regulation of amyloid-beta clearance 1/982 19/18722 0.640907452645148 0.818210859831118 LRP1 1 GO:1903083 protein localization to condensed chromosome 1/982 19/18722 0.640907452645148 0.818210859831118 SPDL1 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/982 19/18722 0.640907452645148 0.818210859831118 PINK1 1 GO:1903975 regulation of glial cell migration 1/982 19/18722 0.640907452645148 0.818210859831118 LRP1 1 GO:2000831 regulation of steroid hormone secretion 1/982 19/18722 0.640907452645148 0.818210859831118 C1QTNF1 1 GO:0048286 lung alveolus development 2/982 41/18722 0.64126648676948 0.818210859831118 FGFR2/PDGFA 2 GO:0060612 adipose tissue development 2/982 41/18722 0.64126648676948 0.818210859831118 LRP5/PPARD 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/982 41/18722 0.64126648676948 0.818210859831118 TMSB4X/PINK1 2 GO:1903524 positive regulation of blood circulation 2/982 41/18722 0.64126648676948 0.818210859831118 ADRB1/ADM 2 GO:2000008 regulation of protein localization to cell surface 2/982 41/18722 0.64126648676948 0.818210859831118 TM9SF4/LEPROT 2 GO:0032006 regulation of TOR signaling 5/982 104/18722 0.642251466680846 0.819066907141147 SLC38A9/SH3BP4/GNA12/RICTOR/RRAGA 5 GO:0045621 positive regulation of lymphocyte differentiation 5/982 104/18722 0.642251466680846 0.819066907141147 SOX4/MMP14/CD46/GLI3/BAD 5 GO:0018210 peptidyl-threonine modification 6/982 125/18722 0.645886114623559 0.823500849150937 APP/BMP7/GALNT11/TRIM6/PARD3/PDPK1 6 GO:0061013 regulation of mRNA catabolic process 8/982 166/18722 0.64737606957376 0.82519882182227 AXIN2/PUM1/TARDBP/YTHDF2/PUM2/DHX9/METTL3/VIM 8 GO:0140014 mitotic nuclear division 14/982 287/18722 0.648673438051412 0.826194684938281 OBSL1/LRP5/BMP7/CENPF/SMC2/CHTF8/ZWINT/SPDL1/EPS8/RACGAP1/TPX2/KMT5A/KIF4A/LCMT1 14 GO:0061157 mRNA destabilization 4/982 84/18722 0.648728493550071 0.826194684938281 PUM1/TARDBP/YTHDF2/METTL3 4 GO:1900542 regulation of purine nucleotide metabolic process 4/982 84/18722 0.648728493550071 0.826194684938281 APP/TMSB4X/PINK1/NUPR1 4 GO:0016239 positive regulation of macroautophagy 3/982 63/18722 0.648949314454014 0.826194684938281 SLC25A4/MAP3K7/PINK1 3 GO:1902373 negative regulation of mRNA catabolic process 3/982 63/18722 0.648949314454014 0.826194684938281 AXIN2/TARDBP/DHX9 3 GO:0009615 response to virus 18/982 367/18722 0.649900182917509 0.826842008565691 SKP2/EIF2AK4/ITGB8/GPAM/ELMOD2/TRIM6/IL10RB/IFI6/PUM1/NCBP3/AP1S1/ZCCHC3/CCL5/CDK6/TSPAN6/PUM2/DHX9/DDX1 18 GO:0002695 negative regulation of leukocyte activation 9/982 187/18722 0.651974613377778 0.826842008565691 CD200/SOCS6/PAWR/FER/DLG5/TNFRSF21/LDLR/GLI3/GRN 9 GO:0001819 positive regulation of cytokine production 23/982 467/18722 0.65332774654311 0.826842008565691 LRP1/CD200/APP/ISL1/CADM1/FERMT1/IL6ST/B2M/CD46/HLA-A/AGPAT1/HRAS/TRIM6/MAP3K7/HILPDA/HLA-E/ZCCHC3/CYBA/DHX9/TRIM27/DDX1/NLRP2/BCL10 23 GO:0031929 TOR signaling 6/982 126/18722 0.653509927234648 0.826842008565691 SLC38A9/SH3BP4/GNA12/PINK1/RICTOR/RRAGA 6 GO:0007212 dopamine receptor signaling pathway 2/982 42/18722 0.654352062032378 0.826842008565691 GNA11/NSG1 2 GO:0007520 myoblast fusion 2/982 42/18722 0.654352062032378 0.826842008565691 ERVW-1/MYOF 2 GO:0009154 purine ribonucleotide catabolic process 2/982 42/18722 0.654352062032378 0.826842008565691 NUDT4/PDE7A 2 GO:0019432 triglyceride biosynthetic process 2/982 42/18722 0.654352062032378 0.826842008565691 GPAM/LDLR 2 GO:0019692 deoxyribose phosphate metabolic process 2/982 42/18722 0.654352062032378 0.826842008565691 DTYMK/ADK 2 GO:0030808 regulation of nucleotide biosynthetic process 2/982 42/18722 0.654352062032378 0.826842008565691 TMSB4X/PINK1 2 GO:0032965 regulation of collagen biosynthetic process 2/982 42/18722 0.654352062032378 0.826842008565691 PPARD/VIM 2 GO:0033574 response to testosterone 2/982 42/18722 0.654352062032378 0.826842008565691 BAD/NME1 2 GO:0045047 protein targeting to ER 2/982 42/18722 0.654352062032378 0.826842008565691 TRAM2/SEC63 2 GO:0048489 synaptic vesicle transport 2/982 42/18722 0.654352062032378 0.826842008565691 SYNJ1/PINK1 2 GO:0060999 positive regulation of dendritic spine development 2/982 42/18722 0.654352062032378 0.826842008565691 DLG5/PPP1R9A 2 GO:2000779 regulation of double-strand break repair 4/982 85/18722 0.65792474546009 0.826842008565691 POLQ/RMI2/MAGEF1/WDR48 4 GO:0042116 macrophage activation 5/982 106/18722 0.658860309899541 0.826842008565691 CD200/APP/LDLR/CEBPA/GRN 5 GO:1903707 negative regulation of hemopoiesis 5/982 106/18722 0.658860309899541 0.826842008565691 FBN1/UBASH3B/GLI3/CDK6/NME1 5 GO:0017156 calcium-ion regulated exocytosis 3/982 64/18722 0.659500534413491 0.826842008565691 SCIN/SYT7/TRPV6 3 GO:0045670 regulation of osteoclast differentiation 3/982 64/18722 0.659500534413491 0.826842008565691 FBN1/UBASH3B/ESRRA 3 GO:0046888 negative regulation of hormone secretion 3/982 64/18722 0.659500534413491 0.826842008565691 GJA1/MAP4K4/ENY2 3 GO:1903409 reactive oxygen species biosynthetic process 3/982 64/18722 0.659500534413491 0.826842008565691 PAGE4/CYBA/SLC5A3 3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/982 20/18722 0.659761587356289 0.826842008565691 BRD4 1 GO:0000963 mitochondrial RNA processing 1/982 20/18722 0.659761587356289 0.826842008565691 TRIT1 1 GO:0001832 blastocyst growth 1/982 20/18722 0.659761587356289 0.826842008565691 BRCA2 1 GO:0003159 morphogenesis of an endothelium 1/982 20/18722 0.659761587356289 0.826842008565691 RBPJ 1 GO:0006590 thyroid hormone generation 1/982 20/18722 0.659761587356289 0.826842008565691 CPQ 1 GO:0006607 NLS-bearing protein import into nucleus 1/982 20/18722 0.659761587356289 0.826842008565691 RANBP2 1 GO:0006837 serotonin transport 1/982 20/18722 0.659761587356289 0.826842008565691 SLC6A4 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/982 20/18722 0.659761587356289 0.826842008565691 AFG3L2 1 GO:0006883 cellular sodium ion homeostasis 1/982 20/18722 0.659761587356289 0.826842008565691 SLC1A3 1 GO:0007097 nuclear migration 1/982 20/18722 0.659761587356289 0.826842008565691 HOOK3 1 GO:0007620 copulation 1/982 20/18722 0.659761587356289 0.826842008565691 SLC6A4 1 GO:0009110 vitamin biosynthetic process 1/982 20/18722 0.659761587356289 0.826842008565691 PSAT1 1 GO:0010042 response to manganese ion 1/982 20/18722 0.659761587356289 0.826842008565691 APP 1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1/982 20/18722 0.659761587356289 0.826842008565691 PARD3 1 GO:0010893 positive regulation of steroid biosynthetic process 1/982 20/18722 0.659761587356289 0.826842008565691 ADM 1 GO:0014047 glutamate secretion 1/982 20/18722 0.659761587356289 0.826842008565691 GJA1 1 GO:0021516 dorsal spinal cord development 1/982 20/18722 0.659761587356289 0.826842008565691 LMO4 1 GO:0031645 negative regulation of nervous system process 1/982 20/18722 0.659761587356289 0.826842008565691 TNFRSF21 1 GO:0032332 positive regulation of chondrocyte differentiation 1/982 20/18722 0.659761587356289 0.826842008565691 GLI3 1 GO:0032495 response to muramyl dipeptide 1/982 20/18722 0.659761587356289 0.826842008565691 VIM 1 GO:0033005 positive regulation of mast cell activation 1/982 20/18722 0.659761587356289 0.826842008565691 SNX4 1 GO:0043555 regulation of translation in response to stress 1/982 20/18722 0.659761587356289 0.826842008565691 EIF2AK4 1 GO:0046485 ether lipid metabolic process 1/982 20/18722 0.659761587356289 0.826842008565691 CHPT1 1 GO:0046629 gamma-delta T cell activation 1/982 20/18722 0.659761587356289 0.826842008565691 SOX4 1 GO:0048670 regulation of collateral sprouting 1/982 20/18722 0.659761587356289 0.826842008565691 LRP1 1 GO:0060231 mesenchymal to epithelial transition 1/982 20/18722 0.659761587356289 0.826842008565691 BASP1 1 GO:0061154 endothelial tube morphogenesis 1/982 20/18722 0.659761587356289 0.826842008565691 RBPJ 1 GO:0070166 enamel mineralization 1/982 20/18722 0.659761587356289 0.826842008565691 SLC4A2 1 GO:0070932 histone H3 deacetylation 1/982 20/18722 0.659761587356289 0.826842008565691 HDAC6 1 GO:0071243 cellular response to arsenic-containing substance 1/982 20/18722 0.659761587356289 0.826842008565691 SLC38A2 1 GO:0071379 cellular response to prostaglandin stimulus 1/982 20/18722 0.659761587356289 0.826842008565691 P2RY6 1 GO:0071731 response to nitric oxide 1/982 20/18722 0.659761587356289 0.826842008565691 CCNA2 1 GO:0072087 renal vesicle development 1/982 20/18722 0.659761587356289 0.826842008565691 KIF26B 1 GO:0072567 chemokine (C-X-C motif) ligand 2 production 1/982 20/18722 0.659761587356289 0.826842008565691 LRP1 1 GO:0097503 sialylation 1/982 20/18722 0.659761587356289 0.826842008565691 ST3GAL6 1 GO:1902004 positive regulation of amyloid-beta formation 1/982 20/18722 0.659761587356289 0.826842008565691 EFNA1 1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/982 20/18722 0.659761587356289 0.826842008565691 PINK1 1 GO:1903817 negative regulation of voltage-gated potassium channel activity 1/982 20/18722 0.659761587356289 0.826842008565691 ANK3 1 GO:1904263 positive regulation of TORC1 signaling 1/982 20/18722 0.659761587356289 0.826842008565691 RRAGA 1 GO:2000010 positive regulation of protein localization to cell surface 1/982 20/18722 0.659761587356289 0.826842008565691 TM9SF4 1 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 1/982 20/18722 0.659761587356289 0.826842008565691 LRP1 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/982 20/18722 0.659761587356289 0.826842008565691 PKIB 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/982 20/18722 0.659761587356289 0.826842008565691 ZNF451 1 GO:0002706 regulation of lymphocyte mediated immunity 8/982 168/18722 0.660577535708737 0.82766572814239 CADM1/TFRC/B2M/CD46/HLA-B/HLA-A/MAP3K7/HLA-E 8 GO:0032409 regulation of transporter activity 15/982 310/18722 0.663451609319773 0.831067145584039 GJA1/APP/TCAF1/WNK2/PPARG/KCNG1/TMSB4X/FXYD3/P2RY6/PINK1/RXRA/ITGB1/ANK3/EHD3/SLC5A3 15 GO:0070507 regulation of microtubule cytoskeleton organization 7/982 148/18722 0.663865584450062 0.831386047657028 MET/EFNA5/GNAI1/HDAC6/CAMSAP2/CLTC/TPX2 7 GO:0006140 regulation of nucleotide metabolic process 4/982 86/18722 0.666957205188584 0.833177999023553 APP/TMSB4X/PINK1/NUPR1 4 GO:0051341 regulation of oxidoreductase activity 5/982 107/18722 0.666975874786246 0.833177999023553 EGFR/PDP2/HDAC6/CYBA/ECSIT 5 GO:0071868 cellular response to monoamine stimulus 5/982 107/18722 0.666975874786246 0.833177999023553 APP/GNA11/ID1/NSG1/TGM2 5 GO:0071870 cellular response to catecholamine stimulus 5/982 107/18722 0.666975874786246 0.833177999023553 APP/GNA11/ID1/NSG1/TGM2 5 GO:0006458 'de novo' protein folding 2/982 43/18722 0.667053551365483 0.833177999023553 DNAJB4/BAG1 2 GO:0031952 regulation of protein autophosphorylation 2/982 43/18722 0.667053551365483 0.833177999023553 PDGFA/RAD50 2 GO:0034661 ncRNA catabolic process 2/982 43/18722 0.667053551365483 0.833177999023553 KCNQ1OT1/LIN28B 2 GO:0045494 photoreceptor cell maintenance 2/982 43/18722 0.667053551365483 0.833177999023553 SLC2A1/NPHP3 2 GO:0045776 negative regulation of blood pressure 2/982 43/18722 0.667053551365483 0.833177999023553 ADRB1/GJA5 2 GO:0090278 negative regulation of peptide hormone secretion 2/982 43/18722 0.667053551365483 0.833177999023553 MAP4K4/ENY2 2 GO:1901381 positive regulation of potassium ion transmembrane transport 2/982 43/18722 0.667053551365483 0.833177999023553 WNK2/KCNN4 2 GO:0035418 protein localization to synapse 3/982 65/18722 0.66982062640073 0.835777036181714 DAG1/HRAS/NSG1 3 GO:0043489 RNA stabilization 3/982 65/18722 0.66982062640073 0.835777036181714 AXIN2/TARDBP/DHX9 3 GO:0046503 glycerolipid catabolic process 3/982 65/18722 0.66982062640073 0.835777036181714 ABHD12/LDLR/PNPLA2 3 GO:0090307 mitotic spindle assembly 3/982 65/18722 0.66982062640073 0.835777036181714 RACGAP1/TPX2/KIF4A 3 GO:0009566 fertilization 9/982 190/18722 0.670474953868782 0.835777036181714 NR2F2/SPESP1/KDM5B/FOLR1/CD46/LY6K/WDR48/SLIRP/CLIC4 9 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/982 129/18722 0.675767367068684 0.835777036181714 PPARG/BCL2L13/GSN/BAD/NLRP2/BCL10 6 GO:0001776 leukocyte homeostasis 4/982 87/18722 0.675824991177469 0.835777036181714 GPAM/JAM3/SLC39A3/BCL10 4 GO:0051262 protein tetramerization 4/982 87/18722 0.675824991177469 0.835777036181714 B2M/TK1/CBY1/RRM1 4 GO:0061014 positive regulation of mRNA catabolic process 4/982 87/18722 0.675824991177469 0.835777036181714 PUM1/TARDBP/YTHDF2/METTL3 4 GO:1903578 regulation of ATP metabolic process 4/982 87/18722 0.675824991177469 0.835777036181714 APP/TMSB4X/PINK1/NUPR1 4 GO:0002689 negative regulation of leukocyte chemotaxis 1/982 21/18722 0.677626741950243 0.835777036181714 DPP4 1 GO:0006067 ethanol metabolic process 1/982 21/18722 0.677626741950243 0.835777036181714 ACSS1 1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 1/982 21/18722 0.677626741950243 0.835777036181714 COX6A1 1 GO:0006353 DNA-templated transcription, termination 1/982 21/18722 0.677626741950243 0.835777036181714 DHX9 1 GO:0006925 inflammatory cell apoptotic process 1/982 21/18722 0.677626741950243 0.835777036181714 CTSL 1 GO:0007289 spermatid nucleus differentiation 1/982 21/18722 0.677626741950243 0.835777036181714 SRPK1 1 GO:0007617 mating behavior 1/982 21/18722 0.677626741950243 0.835777036181714 APP 1 GO:0008090 retrograde axonal transport 1/982 21/18722 0.677626741950243 0.835777036181714 DST 1 GO:0009070 serine family amino acid biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 PSAT1 1 GO:0010766 negative regulation of sodium ion transport 1/982 21/18722 0.677626741950243 0.835777036181714 WNK2 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/982 21/18722 0.677626741950243 0.835777036181714 ANXA2 1 GO:0019370 leukotriene biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 MGST3 1 GO:0019985 translesion synthesis 1/982 21/18722 0.677626741950243 0.835777036181714 USP43 1 GO:0031998 regulation of fatty acid beta-oxidation 1/982 21/18722 0.677626741950243 0.835777036181714 IRS2 1 GO:0032303 regulation of icosanoid secretion 1/982 21/18722 0.677626741950243 0.835777036181714 PTGES 1 GO:0032516 positive regulation of phosphoprotein phosphatase activity 1/982 21/18722 0.677626741950243 0.835777036181714 SLC39A10 1 GO:0034312 diol biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 SPTLC3 1 GO:0035020 regulation of Rac protein signal transduction 1/982 21/18722 0.677626741950243 0.835777036181714 ALS2 1 GO:0035813 regulation of renal sodium excretion 1/982 21/18722 0.677626741950243 0.835777036181714 COMT 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/982 21/18722 0.677626741950243 0.835777036181714 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/982 21/18722 0.677626741950243 0.835777036181714 SLC5A3 1 GO:0045655 regulation of monocyte differentiation 1/982 21/18722 0.677626741950243 0.835777036181714 CDK6 1 GO:0046128 purine ribonucleoside metabolic process 1/982 21/18722 0.677626741950243 0.835777036181714 ADK 1 GO:0046514 ceramide catabolic process 1/982 21/18722 0.677626741950243 0.835777036181714 NEU1 1 GO:0046597 negative regulation of viral entry into host cell 1/982 21/18722 0.677626741950243 0.835777036181714 GSN 1 GO:0046885 regulation of hormone biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 ADM 1 GO:0048745 smooth muscle tissue development 1/982 21/18722 0.677626741950243 0.835777036181714 NF1 1 GO:0050802 circadian sleep/wake cycle, sleep 1/982 21/18722 0.677626741950243 0.835777036181714 ADRB1 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 GSTP1 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 GSTP1 1 GO:0060972 left/right pattern formation 1/982 21/18722 0.677626741950243 0.835777036181714 AHI1 1 GO:0070269 pyroptosis 1/982 21/18722 0.677626741950243 0.835777036181714 DHX9 1 GO:0070584 mitochondrion morphogenesis 1/982 21/18722 0.677626741950243 0.835777036181714 SLIRP 1 GO:0071605 monocyte chemotactic protein-1 production 1/982 21/18722 0.677626741950243 0.835777036181714 GSTP1 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/982 21/18722 0.677626741950243 0.835777036181714 GSTP1 1 GO:0072111 cell proliferation involved in kidney development 1/982 21/18722 0.677626741950243 0.835777036181714 BMP7 1 GO:0150146 cell junction disassembly 1/982 21/18722 0.677626741950243 0.835777036181714 MAP4K4 1 GO:1900118 negative regulation of execution phase of apoptosis 1/982 21/18722 0.677626741950243 0.835777036181714 DFFA 1 GO:1902644 tertiary alcohol metabolic process 1/982 21/18722 0.677626741950243 0.835777036181714 AKR1B1 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/982 21/18722 0.677626741950243 0.835777036181714 PAGE4 1 GO:1903429 regulation of cell maturation 1/982 21/18722 0.677626741950243 0.835777036181714 MAP3K13 1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 1/982 21/18722 0.677626741950243 0.835777036181714 TJP1 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/982 21/18722 0.677626741950243 0.835777036181714 GPC1 1 GO:0002792 negative regulation of peptide secretion 2/982 44/18722 0.679375202834774 0.83700933665067 MAP4K4/ENY2 2 GO:0030521 androgen receptor signaling pathway 2/982 44/18722 0.679375202834774 0.83700933665067 DAB2/HDAC6 2 GO:0046006 regulation of activated T cell proliferation 2/982 44/18722 0.679375202834774 0.83700933665067 GPAM/CD24 2 GO:0060324 face development 2/982 44/18722 0.679375202834774 0.83700933665067 CHD7/DLX5 2 GO:0048469 cell maturation 8/982 171/18722 0.679821542232783 0.83700933665067 APP/PPARG/EPAS1/CEBPA/YTHDF2/MAP3K13/BRCA2/AKR1B1 8 GO:0051048 negative regulation of secretion 8/982 171/18722 0.679821542232783 0.83700933665067 GJA1/CD200/FRMD4A/PPP1R9A/ERBB3/COMT/MAP4K4/ENY2 8 GO:1902476 chloride transmembrane transport 3/982 66/18722 0.679909616447256 0.83700933665067 SLC26A2/GABRE/SLC1A3 3 GO:2000573 positive regulation of DNA biosynthetic process 3/982 66/18722 0.679909616447256 0.83700933665067 CHTF8/PKIB/ATR 3 GO:0043266 regulation of potassium ion transport 5/982 109/18722 0.682824205088052 0.84039079508137 WNK2/KCNG1/KCNN4/ITGB1/ANK3 5 GO:0006352 DNA-templated transcription, initiation 6/982 130/18722 0.682978638870768 0.84039079508137 TFAM/ZNF451/MED16/CAND1/MED24/TAF11 6 GO:0043535 regulation of blood vessel endothelial cell migration 7/982 151/18722 0.684204084153521 0.841700118619049 NRP1/PPARG/NF1/TMSB4X/EFNA1/PLK2/PDPK1 7 GO:0007260 tyrosine phosphorylation of STAT protein 4/982 88/18722 0.684527464286762 0.841700908467645 ISL1/IL6ST/FER/CCL5 4 GO:0031110 regulation of microtubule polymerization or depolymerization 4/982 88/18722 0.684527464286762 0.841700908467645 MET/HDAC6/CAMSAP2/TPX2 4 GO:0001505 regulation of neurotransmitter levels 10/982 213/18722 0.685353280292599 0.842517725667263 SLC6A4/SYT7/SLC1A3/PPP1R9A/SLC29A1/SYNJ1/COMT/CLN3/ITGB1/NAPA 10 GO:0009583 detection of light stimulus 3/982 67/18722 0.689767908589748 0.842903103116208 CDS1/GNA11/OPN3 3 GO:0016445 somatic diversification of immunoglobulins 3/982 67/18722 0.689767908589748 0.842903103116208 TFRC/SWAP70/POLQ 3 GO:0035914 skeletal muscle cell differentiation 3/982 67/18722 0.689767908589748 0.842903103116208 GPC1/NUPR1/KLF5 3 GO:0042130 negative regulation of T cell proliferation 3/982 67/18722 0.689767908589748 0.842903103116208 PAWR/DLG5/TNFRSF21 3 GO:0046635 positive regulation of alpha-beta T cell activation 3/982 67/18722 0.689767908589748 0.842903103116208 HLA-A/GLI3/HLA-E 3 GO:0061077 chaperone-mediated protein folding 3/982 67/18722 0.689767908589748 0.842903103116208 DNAJB4/DFFA/BAG1 3 GO:0072665 protein localization to vacuole 3/982 67/18722 0.689767908589748 0.842903103116208 SH3BP4/RNF128/SCARB2 3 GO:0000723 telomere maintenance 6/982 131/18722 0.690084658375292 0.842903103116208 FEN1/PKIB/ATR/BRCA2/CCNE1/RAD50 6 GO:0018958 phenol-containing compound metabolic process 5/982 110/18722 0.690555423424852 0.842903103116208 EPAS1/COMT/CPQ/AKR1B1/OPN3 5 GO:0031056 regulation of histone modification 7/982 152/18722 0.690806617238783 0.842903103116208 ISL1/BRD4/PINK1/LMNA/ZNF451/RPS6KA4/DNMT1 7 GO:0002920 regulation of humoral immune response 2/982 45/18722 0.691321875401871 0.842903103116208 CD46/CD59 2 GO:0006110 regulation of glycolytic process 2/982 45/18722 0.691321875401871 0.842903103116208 APP/NUPR1 2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 2/982 45/18722 0.691321875401871 0.842903103116208 P4HB/PINK1 2 GO:0010824 regulation of centrosome duplication 2/982 45/18722 0.691321875401871 0.842903103116208 TRIM37/PLK2 2 GO:0032309 icosanoid secretion 2/982 45/18722 0.691321875401871 0.842903103116208 PTGES/PLA2G12A 2 GO:0035307 positive regulation of protein dephosphorylation 2/982 45/18722 0.691321875401871 0.842903103116208 SLC39A10/PINK1 2 GO:0042551 neuron maturation 2/982 45/18722 0.691321875401871 0.842903103116208 APP/MAP3K13 2 GO:0048538 thymus development 2/982 45/18722 0.691321875401871 0.842903103116208 PBX1/LMO4 2 GO:0048599 oocyte development 2/982 45/18722 0.691321875401871 0.842903103116208 YTHDF2/BRCA2 2 GO:0085029 extracellular matrix assembly 2/982 45/18722 0.691321875401871 0.842903103116208 LAMB1/DAG1 2 GO:0010469 regulation of signaling receptor activity 8/982 173/18722 0.692269836344213 0.842903103116208 APP/NRP1/PPARG/PHLDA2/NCOA3/HDAC6/PINK1/ITGB1 8 GO:1904062 regulation of cation transmembrane transport 17/982 357/18722 0.694345739969792 0.842903103116208 APP/UBASH3B/WNK2/KCNG1/CHD7/SLC43A2/TMSB4X/FXYD3/TSPAN13/KCNN4/P2RY6/CYBA/PINK1/ITGB1/ANK3/EHD3/PDPK1 17 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 1/982 22/18722 0.694554742560096 0.842903103116208 ADM 1 GO:0002089 lens morphogenesis in camera-type eye 1/982 22/18722 0.694554742560096 0.842903103116208 BCAR3 1 GO:0002220 innate immune response activating cell surface receptor signaling pathway 1/982 22/18722 0.694554742560096 0.842903103116208 MAP3K7 1 GO:0002320 lymphoid progenitor cell differentiation 1/982 22/18722 0.694554742560096 0.842903103116208 SOX4 1 GO:0006662 glycerol ether metabolic process 1/982 22/18722 0.694554742560096 0.842903103116208 CHPT1 1 GO:0007398 ectoderm development 1/982 22/18722 0.694554742560096 0.842903103116208 ITGA6 1 GO:0010866 regulation of triglyceride biosynthetic process 1/982 22/18722 0.694554742560096 0.842903103116208 LDLR 1 GO:0014821 phasic smooth muscle contraction 1/982 22/18722 0.694554742560096 0.842903103116208 TBX3 1 GO:0019400 alditol metabolic process 1/982 22/18722 0.694554742560096 0.842903103116208 AKR1B1 1 GO:0021904 dorsal/ventral neural tube patterning 1/982 22/18722 0.694554742560096 0.842903103116208 GLI3 1 GO:0022401 negative adaptation of signaling pathway 1/982 22/18722 0.694554742560096 0.842903103116208 ADM 1 GO:0022616 DNA strand elongation 1/982 22/18722 0.694554742560096 0.842903103116208 RAD50 1 GO:0031061 negative regulation of histone methylation 1/982 22/18722 0.694554742560096 0.842903103116208 DNMT1 1 GO:0031281 positive regulation of cyclase activity 1/982 22/18722 0.694554742560096 0.842903103116208 NF1 1 GO:0032098 regulation of appetite 1/982 22/18722 0.694554742560096 0.842903103116208 NENF 1 GO:0032693 negative regulation of interleukin-10 production 1/982 22/18722 0.694554742560096 0.842903103116208 TNFRSF21 1 GO:0032727 positive regulation of interferon-alpha production 1/982 22/18722 0.694554742560096 0.842903103116208 DHX9 1 GO:0032816 positive regulation of natural killer cell activation 1/982 22/18722 0.694554742560096 0.842903103116208 HLA-E 1 GO:0034629 cellular protein-containing complex localization 1/982 22/18722 0.694554742560096 0.842903103116208 WASL 1 GO:0042749 regulation of circadian sleep/wake cycle 1/982 22/18722 0.694554742560096 0.842903103116208 ADRB1 1 GO:0043486 histone exchange 1/982 22/18722 0.694554742560096 0.842903103116208 CENPW 1 GO:0045048 protein insertion into ER membrane 1/982 22/18722 0.694554742560096 0.842903103116208 TRAM2 1 GO:0045061 thymic T cell selection 1/982 22/18722 0.694554742560096 0.842903103116208 GLI3 1 GO:0046058 cAMP metabolic process 1/982 22/18722 0.694554742560096 0.842903103116208 PDE7A 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/982 22/18722 0.694554742560096 0.842903103116208 SORBS1 1 GO:0050860 negative regulation of T cell receptor signaling pathway 1/982 22/18722 0.694554742560096 0.842903103116208 PAWR 1 GO:0051220 cytoplasmic sequestering of protein 1/982 22/18722 0.694554742560096 0.842903103116208 TMSB4X 1 GO:0071467 cellular response to pH 1/982 22/18722 0.694554742560096 0.842903103116208 GNA11 1 GO:0072574 hepatocyte proliferation 1/982 22/18722 0.694554742560096 0.842903103116208 PTN 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/982 22/18722 0.694554742560096 0.842903103116208 PTN 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/982 22/18722 0.694554742560096 0.842903103116208 ANK3 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/982 22/18722 0.694554742560096 0.842903103116208 NUPR1 1 GO:2000193 positive regulation of fatty acid transport 1/982 22/18722 0.694554742560096 0.842903103116208 PTGES 1 GO:0007338 single fertilization 7/982 153/18722 0.697319581359934 0.84606162744206 SPESP1/KDM5B/FOLR1/CD46/LY6K/WDR48/SLIRP 7 GO:0071867 response to monoamine 5/982 111/18722 0.698157236360837 0.846611948219134 APP/GNA11/ID1/NSG1/TGM2 5 GO:0071869 response to catecholamine 5/982 111/18722 0.698157236360837 0.846611948219134 APP/GNA11/ID1/NSG1/TGM2 5 GO:0000209 protein polyubiquitination 11/982 236/18722 0.698945289433871 0.846611948219134 SKP2/TRIML2/KLHL42/TRIM6/HDAC6/MDM2/UBE4B/RNF114/FBXO22/TRIM27/HUWE1 11 GO:0016072 rRNA metabolic process 11/982 236/18722 0.698945289433871 0.846611948219134 CHD7/MAK16/NPM3/REXO4/ERI2/RPF2/YTHDF2/WDR43/HEATR1/MPHOSPH10/DCAF13 11 GO:0090068 positive regulation of cell cycle process 11/982 236/18722 0.698945289433871 0.846611948219134 ADAMTS1/PBX1/EGFR/APP/LRP5/BRD4/MTA3/CCND1/RACGAP1/FEN1/MDM2 11 GO:0009988 cell-cell recognition 3/982 68/18722 0.699396258603575 0.846611948219134 SPESP1/FOLR1/LY6K 3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 3/982 68/18722 0.699396258603575 0.846611948219134 ISL1/IL6ST/CCL5 3 GO:0051148 negative regulation of muscle cell differentiation 3/982 68/18722 0.699396258603575 0.846611948219134 BHLHE41/FOXO4/DNMT1 3 GO:1901016 regulation of potassium ion transmembrane transporter activity 3/982 68/18722 0.699396258603575 0.846611948219134 KCNG1/ITGB1/ANK3 3 GO:1902305 regulation of sodium ion transmembrane transport 3/982 68/18722 0.699396258603575 0.846611948219134 WNK2/FXYD3/ANK3 3 GO:0035304 regulation of protein dephosphorylation 4/982 90/18722 0.701435058566863 0.848095796357153 SWAP70/SLC39A10/PINK1/HSP90B1 4 GO:0045638 negative regulation of myeloid cell differentiation 4/982 90/18722 0.701435058566863 0.848095796357153 FBN1/UBASH3B/CDK6/NME1 4 GO:0046031 ADP metabolic process 4/982 90/18722 0.701435058566863 0.848095796357153 APP/NUPR1/DHTKD1/BAD 4 GO:0070664 negative regulation of leukocyte proliferation 4/982 90/18722 0.701435058566863 0.848095796357153 PAWR/DLG5/TNFRSF21/GSTP1 4 GO:0099175 regulation of postsynapse organization 4/982 90/18722 0.701435058566863 0.848095796357153 NRP2/SEMA3F/PPP1R9A/EFNA1 4 GO:0006195 purine nucleotide catabolic process 2/982 46/18722 0.702898963286941 0.84848900543964 NUDT4/PDE7A 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/982 46/18722 0.702898963286941 0.84848900543964 TENM3/CADM1 2 GO:0031057 negative regulation of histone modification 2/982 46/18722 0.702898963286941 0.84848900543964 ZNF451/DNMT1 2 GO:0032924 activin receptor signaling pathway 2/982 46/18722 0.702898963286941 0.84848900543964 ACVR2B/DACT2 2 GO:0035094 response to nicotine 2/982 46/18722 0.702898963286941 0.84848900543964 B2M/BAD 2 GO:0070828 heterochromatin organization 2/982 46/18722 0.702898963286941 0.84848900543964 TRIM28/DNMT1 2 GO:0072599 establishment of protein localization to endoplasmic reticulum 2/982 46/18722 0.702898963286941 0.84848900543964 TRAM2/SEC63 2 GO:0002697 regulation of immune effector process 16/982 339/18722 0.704032810684033 0.849557371734572 CADM1/TFRC/FER/B2M/CD46/HLA-B/HLA-A/TRIM6/SNX4/MAP3K7/HLA-E/CD59/GRN/PDPK1/DDX1/BCL10 16 GO:0006401 RNA catabolic process 13/982 278/18722 0.704272637151129 0.849557371734572 KCNQ1OT1/LIN28B/AXIN2/PUM1/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/VIM 13 GO:0007281 germ cell development 13/982 278/18722 0.704272637151129 0.849557371734572 LGR5/ETV5/PTN/ASPM/JAM3/HOOK1/SMARCA2/YTHDF2/BRCA2/METTL3/SLIRP/SMAD5/SRPK1 13 GO:0001676 long-chain fatty acid metabolic process 5/982 112/18722 0.705629247433457 0.849716177439012 SLC27A2/ABHD12/ACSF2/CYP2J2/GSTP1 5 GO:0010633 negative regulation of epithelial cell migration 5/982 112/18722 0.705629247433457 0.849716177439012 NR2F2/TACSTD2/PPARG/MARVELD3/SERPINF1 5 GO:0007004 telomere maintenance via telomerase 3/982 69/18722 0.708795748745927 0.849716177439012 PKIB/ATR/RAD50 3 GO:0010611 regulation of cardiac muscle hypertrophy 3/982 69/18722 0.708795748745927 0.849716177439012 PARP2/IL6ST/LMNA 3 GO:0019226 transmission of nerve impulse 3/982 69/18722 0.708795748745927 0.849716177439012 CLDN19/JAM3/ANK3 3 GO:0031060 regulation of histone methylation 3/982 69/18722 0.708795748745927 0.849716177439012 BRD4/LMNA/DNMT1 3 GO:0045582 positive regulation of T cell differentiation 4/982 91/18722 0.709640010899053 0.849716177439012 SOX4/CD46/GLI3/BAD 4 GO:0051952 regulation of amine transport 4/982 91/18722 0.709640010899053 0.849716177439012 SYT7/SLC43A2/PINK1/ITGB1 4 GO:0007519 skeletal muscle tissue development 7/982 155/18722 0.710074764035292 0.849716177439012 NR2F2/GPC1/FLNB/NUPR1/BIN3/FBXO22/KLF5 7 GO:0002363 alpha-beta T cell lineage commitment 1/982 23/18722 0.710594702068438 0.849716177439012 CTSL 1 GO:0002758 innate immune response-activating signal transduction 1/982 23/18722 0.710594702068438 0.849716177439012 MAP3K7 1 GO:0006622 protein targeting to lysosome 1/982 23/18722 0.710594702068438 0.849716177439012 SCARB2 1 GO:0007130 synaptonemal complex assembly 1/982 23/18722 0.710594702068438 0.849716177439012 P3H4 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/982 23/18722 0.710594702068438 0.849716177439012 TK1 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/982 23/18722 0.710594702068438 0.849716177439012 LRP1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/982 23/18722 0.710594702068438 0.849716177439012 GSTP1 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/982 23/18722 0.710594702068438 0.849716177439012 ENY2 1 GO:0021544 subpallium development 1/982 23/18722 0.710594702068438 0.849716177439012 GLI3 1 GO:0023058 adaptation of signaling pathway 1/982 23/18722 0.710594702068438 0.849716177439012 ADM 1 GO:0035162 embryonic hemopoiesis 1/982 23/18722 0.710594702068438 0.849716177439012 PBX1 1 GO:0035640 exploration behavior 1/982 23/18722 0.710594702068438 0.849716177439012 DPP4 1 GO:0035929 steroid hormone secretion 1/982 23/18722 0.710594702068438 0.849716177439012 C1QTNF1 1 GO:0040019 positive regulation of embryonic development 1/982 23/18722 0.710594702068438 0.849716177439012 AMOT 1 GO:0042026 protein refolding 1/982 23/18722 0.710594702068438 0.849716177439012 B2M 1 GO:0042438 melanin biosynthetic process 1/982 23/18722 0.710594702068438 0.849716177439012 OPN3 1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1/982 23/18722 0.710594702068438 0.849716177439012 HDAC6 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/982 23/18722 0.710594702068438 0.849716177439012 CTSL 1 GO:0045724 positive regulation of cilium assembly 1/982 23/18722 0.710594702068438 0.849716177439012 CEP135 1 GO:0045980 negative regulation of nucleotide metabolic process 1/982 23/18722 0.710594702068438 0.849716177439012 NUPR1 1 GO:0051349 positive regulation of lyase activity 1/982 23/18722 0.710594702068438 0.849716177439012 NF1 1 GO:0051590 positive regulation of neurotransmitter transport 1/982 23/18722 0.710594702068438 0.849716177439012 ITGB1 1 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 1/982 23/18722 0.710594702068438 0.849716177439012 GJA5 1 GO:0060353 regulation of cell adhesion molecule production 1/982 23/18722 0.710594702068438 0.849716177439012 COLEC12 1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 1/982 23/18722 0.710594702068438 0.849716177439012 PARP2 1 GO:0071514 genetic imprinting 1/982 23/18722 0.710594702068438 0.849716177439012 TRIM28 1 GO:0072576 liver morphogenesis 1/982 23/18722 0.710594702068438 0.849716177439012 PTN 1 GO:0072677 eosinophil migration 1/982 23/18722 0.710594702068438 0.849716177439012 CCL5 1 GO:0090335 regulation of brown fat cell differentiation 1/982 23/18722 0.710594702068438 0.849716177439012 BMP7 1 GO:0006816 calcium ion transport 20/982 422/18722 0.712486817338969 0.851783460747206 GJA1/ITGAV/MCOLN3/UBASH3B/CHD7/TRPV6/CAMK2G/WFS1/ATP2B1/TSPAN13/KCNN4/P2RY6/CCL5/CYBA/TMEM37/AFG3L2/EHD3/ANXA2/TRIM27/PDPK1 20 GO:0006998 nuclear envelope organization 2/982 47/18722 0.71411232657179 0.851969326486381 TARDBP/LMNA 2 GO:0009261 ribonucleotide catabolic process 2/982 47/18722 0.71411232657179 0.851969326486381 NUDT4/PDE7A 2 GO:0032369 negative regulation of lipid transport 2/982 47/18722 0.71411232657179 0.851969326486381 ITGAV/IRS2 2 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 2/982 47/18722 0.71411232657179 0.851969326486381 EPAS1/RBPJ 2 GO:0045601 regulation of endothelial cell differentiation 2/982 47/18722 0.71411232657179 0.851969326486381 ID1/F11R 2 GO:0045646 regulation of erythrocyte differentiation 2/982 47/18722 0.71411232657179 0.851969326486381 B2M/CDK6 2 GO:0045911 positive regulation of DNA recombination 2/982 47/18722 0.71411232657179 0.851969326486381 TFRC/WDR48 2 GO:0050798 activated T cell proliferation 2/982 47/18722 0.71411232657179 0.851969326486381 GPAM/CD24 2 GO:0061001 regulation of dendritic spine morphogenesis 2/982 47/18722 0.71411232657179 0.851969326486381 PPP1R9A/EFNA1 2 GO:0035249 synaptic transmission, glutamatergic 4/982 92/18722 0.717679290582191 0.855833374411684 EGFR/ALS2/CLN3/NAPA 4 GO:1903351 cellular response to dopamine 4/982 92/18722 0.717679290582191 0.855833374411684 GNA11/ID1/NSG1/TGM2 4 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 3/982 70/18722 0.7179677635117 0.85598168102332 TFRC/SWAP70/B2M 3 GO:0032496 response to lipopolysaccharide 16/982 343/18722 0.721174470698257 0.858443794348766 GJA1/FGFR2/FER/ALAD/ADM/GNG12/TRIM6/PTGES/COMT/SPARC/PPARD/CCL5/GSTP1/VIM/ASS1/BCL10 16 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 2/982 48/18722 0.724968227597685 0.858443794348766 ATR/BRCA2 2 GO:0045912 negative regulation of carbohydrate metabolic process 2/982 48/18722 0.724968227597685 0.858443794348766 CLTC/NUPR1 2 GO:0090311 regulation of protein deacetylation 2/982 48/18722 0.724968227597685 0.858443794348766 BEX4/PINK1 2 GO:0120009 intermembrane lipid transfer 2/982 48/18722 0.724968227597685 0.858443794348766 PLEKHA8/TRIAP1 2 GO:0045132 meiotic chromosome segregation 4/982 93/18722 0.725553301677585 0.858443794348766 SMC2/P3H4/TOP2A/CCNE1 4 GO:1903350 response to dopamine 4/982 93/18722 0.725553301677585 0.858443794348766 GNA11/ID1/NSG1/TGM2 4 GO:0000395 mRNA 5'-splice site recognition 1/982 24/18722 0.725793162016499 0.858443794348766 PRPF39 1 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/982 24/18722 0.725793162016499 0.858443794348766 ERI2 1 GO:0001779 natural killer cell differentiation 1/982 24/18722 0.725793162016499 0.858443794348766 PBX1 1 GO:0002021 response to dietary excess 1/982 24/18722 0.725793162016499 0.858443794348766 ADRB1 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/982 24/18722 0.725793162016499 0.858443794348766 HLA-E 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/982 24/18722 0.725793162016499 0.858443794348766 MAP3K7 1 GO:0006582 melanin metabolic process 1/982 24/18722 0.725793162016499 0.858443794348766 OPN3 1 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 1/982 24/18722 0.725793162016499 0.858443794348766 DTYMK 1 GO:0010155 regulation of proton transport 1/982 24/18722 0.725793162016499 0.858443794348766 TMSB4X 1 GO:0016048 detection of temperature stimulus 1/982 24/18722 0.725793162016499 0.858443794348766 NR2F6 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/982 24/18722 0.725793162016499 0.858443794348766 ZDHHC3 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/982 24/18722 0.725793162016499 0.858443794348766 ZDHHC3 1 GO:0022410 circadian sleep/wake cycle process 1/982 24/18722 0.725793162016499 0.858443794348766 ADRB1 1 GO:0031639 plasminogen activation 1/982 24/18722 0.725793162016499 0.858443794348766 DHCR24 1 GO:0032528 microvillus organization 1/982 24/18722 0.725793162016499 0.858443794348766 KLF5 1 GO:0035458 cellular response to interferon-beta 1/982 24/18722 0.725793162016499 0.858443794348766 TRIM6 1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 1/982 24/18722 0.725793162016499 0.858443794348766 RBPJ 1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1/982 24/18722 0.725793162016499 0.858443794348766 GPC1 1 GO:0043302 positive regulation of leukocyte degranulation 1/982 24/18722 0.725793162016499 0.858443794348766 SNX4 1 GO:0044062 regulation of excretion 1/982 24/18722 0.725793162016499 0.858443794348766 COMT 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/982 24/18722 0.725793162016499 0.858443794348766 CYFIP1 1 GO:0050687 negative regulation of defense response to virus 1/982 24/18722 0.725793162016499 0.858443794348766 TSPAN6 1 GO:0050855 regulation of B cell receptor signaling pathway 1/982 24/18722 0.725793162016499 0.858443794348766 SLC39A10 1 GO:0051647 nucleus localization 1/982 24/18722 0.725793162016499 0.858443794348766 HOOK3 1 GO:0051923 sulfation 1/982 24/18722 0.725793162016499 0.858443794348766 EXT2 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/982 24/18722 0.725793162016499 0.858443794348766 TARDBP 1 GO:1901984 negative regulation of protein acetylation 1/982 24/18722 0.725793162016499 0.858443794348766 ZNF451 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/982 24/18722 0.725793162016499 0.858443794348766 PRKCI 1 GO:0034968 histone lysine methylation 5/982 115/18722 0.727264576264147 0.85959937226236 BRD4/TET2/LMNA/DNMT1/KMT5A 5 GO:0043279 response to alkaloid 5/982 115/18722 0.727264576264147 0.85959937226236 SLC1A3/TGM2/MDM2/DHX15/CCNA2 5 GO:0090630 activation of GTPase activity 5/982 115/18722 0.727264576264147 0.85959937226236 PIP5K1A/SYDE2/EVI5/TBC1D4/TBC1D12 5 GO:0007586 digestion 6/982 137/18722 0.730482910003011 0.86320771603437 ACO1/LDLR/TJP2/KCNN4/LIMA1/F11R 6 GO:0006403 RNA localization 9/982 201/18722 0.733097782654777 0.865274112179474 IGF2BP3/NCBP3/ATR/DHX9/NUP153/RANBP2/UPF3A/TST/ENY2 9 GO:0002042 cell migration involved in sprouting angiogenesis 4/982 94/18722 0.733262624534759 0.865274112179474 NRP1/EPHB4/ITGB1/PLK2 4 GO:0032091 negative regulation of protein binding 4/982 94/18722 0.733262624534759 0.865274112179474 B2M/ID1/DAB2/PTPRF 4 GO:0043543 protein acylation 11/982 243/18722 0.734208671937296 0.865274112179474 ISL1/SOX4/MAP3K7/NCOA3/MORF4L2/ZNF451/NUPR1/ZDHHC3/BRCA2/RPS6KA4/MED24 11 GO:0018107 peptidyl-threonine phosphorylation 5/982 116/18722 0.734216137065683 0.865274112179474 APP/BMP7/TRIM6/PARD3/PDPK1 5 GO:1903169 regulation of calcium ion transmembrane transport 7/982 159/18722 0.734492149136321 0.865274112179474 UBASH3B/CHD7/TSPAN13/P2RY6/CYBA/EHD3/PDPK1 7 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 2/982 49/18722 0.735473272741923 0.865274112179474 TFRC/SWAP70 2 GO:0002208 somatic diversification of immunoglobulins involved in immune response 2/982 49/18722 0.735473272741923 0.865274112179474 TFRC/SWAP70 2 GO:0006953 acute-phase response 2/982 49/18722 0.735473272741923 0.865274112179474 PTGES/ASS1 2 GO:0021695 cerebellar cortex development 2/982 49/18722 0.735473272741923 0.865274112179474 NAGLU/RERE 2 GO:0030225 macrophage differentiation 2/982 49/18722 0.735473272741923 0.865274112179474 APP/CEBPA 2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2/982 49/18722 0.735473272741923 0.865274112179474 SKP2/FBXW4 2 GO:0042304 regulation of fatty acid biosynthetic process 2/982 49/18722 0.735473272741923 0.865274112179474 ACADVL/INSIG1 2 GO:0045190 isotype switching 2/982 49/18722 0.735473272741923 0.865274112179474 TFRC/SWAP70 2 GO:0046605 regulation of centrosome cycle 2/982 49/18722 0.735473272741923 0.865274112179474 TRIM37/PLK2 2 GO:0051445 regulation of meiotic cell cycle 2/982 49/18722 0.735473272741923 0.865274112179474 ASPM/METTL3 2 GO:0014743 regulation of muscle hypertrophy 3/982 72/18722 0.735636277686947 0.865274112179474 PARP2/IL6ST/LMNA 3 GO:1903706 regulation of hemopoiesis 17/982 367/18722 0.735772561942057 0.865274112179474 FBN1/SCIN/CSF3R/SOX4/UBASH3B/MMP14/PTN/B2M/CD46/HLA-B/RCOR1/GLI3/ESRRA/CDK6/METTL3/BAD/NME1 17 GO:0044782 cilium organization 17/982 368/18722 0.739712963598068 0.865274112179474 LAMA5/YAP1/LIMK2/GALNT11/FNBP1L/HDAC6/IFT74/NPHP3/RILPL1/AHI1/TCTN3/GSN/RAB17/DYNLL2/EHD3/SDCCAG8/CEP135 17 GO:0032331 negative regulation of chondrocyte differentiation 1/982 25/18722 0.740194227098315 0.865274112179474 EFEMP1 1 GO:0032753 positive regulation of interleukin-4 production 1/982 25/18722 0.740194227098315 0.865274112179474 HLA-E 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/982 25/18722 0.740194227098315 0.865274112179474 HSD17B12 1 GO:0042730 fibrinolysis 1/982 25/18722 0.740194227098315 0.865274112179474 ANXA2 1 GO:0042832 defense response to protozoan 1/982 25/18722 0.740194227098315 0.865274112179474 HRAS 1 GO:0044550 secondary metabolite biosynthetic process 1/982 25/18722 0.740194227098315 0.865274112179474 OPN3 1 GO:0045324 late endosome to vacuole transport 1/982 25/18722 0.740194227098315 0.865274112179474 LEPROT 1 GO:0050927 positive regulation of positive chemotaxis 1/982 25/18722 0.740194227098315 0.865274112179474 PGF 1 GO:0050951 sensory perception of temperature stimulus 1/982 25/18722 0.740194227098315 0.865274112179474 NR2F6 1 GO:0051291 protein heterooligomerization 1/982 25/18722 0.740194227098315 0.865274112179474 RRM1 1 GO:0051307 meiotic chromosome separation 1/982 25/18722 0.740194227098315 0.865274112179474 TOP2A 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/982 25/18722 0.740194227098315 0.865274112179474 NR2F6 1 GO:0070199 establishment of protein localization to chromosome 1/982 25/18722 0.740194227098315 0.865274112179474 BRCA2 1 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 1/982 25/18722 0.740194227098315 0.865274112179474 MAP3K7 1 GO:0071459 protein localization to chromosome, centromeric region 1/982 25/18722 0.740194227098315 0.865274112179474 SPDL1 1 GO:0072012 glomerulus vasculature development 1/982 25/18722 0.740194227098315 0.865274112179474 BMP7 1 GO:0090312 positive regulation of protein deacetylation 1/982 25/18722 0.740194227098315 0.865274112179474 PINK1 1 GO:0098703 calcium ion import across plasma membrane 1/982 25/18722 0.740194227098315 0.865274112179474 TRPV6 1 GO:0099560 synaptic membrane adhesion 1/982 25/18722 0.740194227098315 0.865274112179474 PTPRF 1 GO:1901623 regulation of lymphocyte chemotaxis 1/982 25/18722 0.740194227098315 0.865274112179474 CCL5 1 GO:1901798 positive regulation of signal transduction by p53 class mediator 1/982 25/18722 0.740194227098315 0.865274112179474 ATR 1 GO:1902932 positive regulation of alcohol biosynthetic process 1/982 25/18722 0.740194227098315 0.865274112179474 P2RY6 1 GO:1902993 positive regulation of amyloid precursor protein catabolic process 1/982 25/18722 0.740194227098315 0.865274112179474 EFNA1 1 GO:1903055 positive regulation of extracellular matrix organization 1/982 25/18722 0.740194227098315 0.865274112179474 DAG1 1 GO:1903901 negative regulation of viral life cycle 1/982 25/18722 0.740194227098315 0.865274112179474 GSN 1 GO:1904385 cellular response to angiotensin 1/982 25/18722 0.740194227098315 0.865274112179474 CYBA 1 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 1/982 25/18722 0.740194227098315 0.865274112179474 GNA12 1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 1/982 25/18722 0.740194227098315 0.865274112179474 NFAT5 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/982 25/18722 0.740194227098315 0.865274112179474 PDPK1 1 GO:0060402 calcium ion transport into cytosol 7/982 160/18722 0.740367553065221 0.865282804568271 MCOLN3/UBASH3B/CHD7/TRPV6/P2RY6/CYBA/PDPK1 7 GO:0051225 spindle assembly 5/982 117/18722 0.741037905189133 0.865678323284774 ASPM/RACGAP1/TPX2/KIF4A/SAC3D1 5 GO:0072676 lymphocyte migration 5/982 117/18722 0.741037905189133 0.865678323284774 CD200/APP/WASL/CCL5/F11R 5 GO:0032732 positive regulation of interleukin-1 production 3/982 73/18722 0.744136853188874 0.868713160041995 APP/ISL1/NLRP2 3 GO:1904427 positive regulation of calcium ion transmembrane transport 3/982 73/18722 0.744136853188874 0.868713160041995 P2RY6/EHD3/PDPK1 3 GO:0001961 positive regulation of cytokine-mediated signaling pathway 2/982 50/18722 0.745634359184818 0.868713160041995 AGPAT1/TRIM6 2 GO:0002639 positive regulation of immunoglobulin production 2/982 50/18722 0.745634359184818 0.868713160041995 TFRC/HLA-E 2 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/982 50/18722 0.745634359184818 0.868713160041995 NUPR1/PDPK1 2 GO:0015872 dopamine transport 2/982 50/18722 0.745634359184818 0.868713160041995 SYT7/PINK1 2 GO:0030490 maturation of SSU-rRNA 2/982 50/18722 0.745634359184818 0.868713160041995 HEATR1/DCAF13 2 GO:0043268 positive regulation of potassium ion transport 2/982 50/18722 0.745634359184818 0.868713160041995 WNK2/KCNN4 2 GO:0045058 T cell selection 2/982 50/18722 0.745634359184818 0.868713160041995 CTSL/GLI3 2 GO:0051646 mitochondrion localization 2/982 50/18722 0.745634359184818 0.868713160041995 HDAC6/ARMCX3 2 GO:0090102 cochlea development 2/982 50/18722 0.745634359184818 0.868713160041995 MCM2/CCNA2 2 GO:1901570 fatty acid derivative biosynthetic process 2/982 50/18722 0.745634359184818 0.868713160041995 SLC25A1/HSD17B12 2 GO:0071346 cellular response to interferon-gamma 5/982 118/18722 0.747730241216503 0.870960459621545 PPARG/CCL5/FLNB/VIM/ASS1 5 GO:0001562 response to protozoan 1/982 26/18722 0.75383969262698 0.873589832646596 HRAS 1 GO:0002092 positive regulation of receptor internalization 1/982 26/18722 0.75383969262698 0.873589832646596 AHI1 1 GO:0002407 dendritic cell chemotaxis 1/982 26/18722 0.75383969262698 0.873589832646596 CCL5 1 GO:0002418 immune response to tumor cell 1/982 26/18722 0.75383969262698 0.873589832646596 HLA-A 1 GO:0006517 protein deglycosylation 1/982 26/18722 0.75383969262698 0.873589832646596 UGGT2 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/982 26/18722 0.75383969262698 0.873589832646596 GABRE 1 GO:0009435 NAD biosynthetic process 1/982 26/18722 0.75383969262698 0.873589832646596 QPRT 1 GO:0014829 vascular associated smooth muscle contraction 1/982 26/18722 0.75383969262698 0.873589832646596 ATP2B1 1 GO:0032682 negative regulation of chemokine production 1/982 26/18722 0.75383969262698 0.873589832646596 GSTP1 1 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 1/982 26/18722 0.75383969262698 0.873589832646596 MAP3K7 1 GO:0042278 purine nucleoside metabolic process 1/982 26/18722 0.75383969262698 0.873589832646596 ADK 1 GO:0043094 cellular metabolic compound salvage 1/982 26/18722 0.75383969262698 0.873589832646596 ADK 1 GO:0043501 skeletal muscle adaptation 1/982 26/18722 0.75383969262698 0.873589832646596 CAMK2G 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/982 26/18722 0.75383969262698 0.873589832646596 GLI3 1 GO:0050926 regulation of positive chemotaxis 1/982 26/18722 0.75383969262698 0.873589832646596 PGF 1 GO:0060352 cell adhesion molecule production 1/982 26/18722 0.75383969262698 0.873589832646596 COLEC12 1 GO:0070193 synaptonemal complex organization 1/982 26/18722 0.75383969262698 0.873589832646596 P3H4 1 GO:0071425 hematopoietic stem cell proliferation 1/982 26/18722 0.75383969262698 0.873589832646596 YTHDF2 1 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1/982 26/18722 0.75383969262698 0.873589832646596 ADRB1 1 GO:0099637 neurotransmitter receptor transport 1/982 26/18722 0.75383969262698 0.873589832646596 NSG1 1 GO:1902656 calcium ion import into cytosol 1/982 26/18722 0.75383969262698 0.873589832646596 TRPV6 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/982 26/18722 0.75383969262698 0.873589832646596 DNMT1 1 GO:2000108 positive regulation of leukocyte apoptotic process 1/982 26/18722 0.75383969262698 0.873589832646596 CCL5 1 GO:2001257 regulation of cation channel activity 8/982 184/18722 0.755104093217436 0.874494495074322 APP/KCNG1/TMSB4X/P2RY6/PINK1/ITGB1/ANK3/EHD3 8 GO:1903038 negative regulation of leukocyte cell-cell adhesion 6/982 141/18722 0.755269189297494 0.874494495074322 SOCS6/PAWR/DLG5/TNFRSF21/GLI3/ASS1 6 GO:0009584 detection of visible light 2/982 51/18722 0.75545862630462 0.874494495074322 GNA11/OPN3 2 GO:0065002 intracellular protein transmembrane transport 2/982 51/18722 0.75545862630462 0.874494495074322 TRAM2/SEC63 2 GO:1903307 positive regulation of regulated secretory pathway 2/982 51/18722 0.75545862630462 0.874494495074322 SYT7/SNX4 2 GO:0006278 RNA-dependent DNA biosynthetic process 3/982 75/18722 0.760482477263748 0.879724240720272 PKIB/ATR/RAD50 3 GO:0034121 regulation of toll-like receptor signaling pathway 3/982 75/18722 0.760482477263748 0.879724240720272 LGR4/CYBA/PDPK1 3 GO:0036465 synaptic vesicle recycling 3/982 75/18722 0.760482477263748 0.879724240720272 SYT7/CYFIP1/SYNJ1 3 GO:0002761 regulation of myeloid leukocyte differentiation 5/982 120/18722 0.760728587523652 0.879813816524028 FBN1/UBASH3B/ESRRA/CDK6/NME1 5 GO:0070588 calcium ion transmembrane transport 14/982 312/18722 0.763176335934567 0.880746083772912 ITGAV/MCOLN3/UBASH3B/CHD7/TRPV6/ATP2B1/TSPAN13/P2RY6/CYBA/TMEM37/AFG3L2/EHD3/ANXA2/PDPK1 14 GO:0007129 homologous chromosome pairing at meiosis 2/982 52/18722 0.764953411362127 0.880746083772912 P3H4/CCNE1 2 GO:0035176 social behavior 2/982 52/18722 0.764953411362127 0.880746083772912 SLC6A4/SHANK2 2 GO:0051496 positive regulation of stress fiber assembly 2/982 52/18722 0.764953411362127 0.880746083772912 NRP1/FERMT2 2 GO:0072523 purine-containing compound catabolic process 2/982 52/18722 0.764953411362127 0.880746083772912 NUDT4/PDE7A 2 GO:0071706 tumor necrosis factor superfamily cytokine production 8/982 186/18722 0.765490441915733 0.880746083772912 APP/ISL1/HLA-E/CYBA/GSTP1/DHX9/TRIM27/BCL10 8 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 8/982 186/18722 0.765490441915733 0.880746083772912 APP/ISL1/HLA-E/CYBA/GSTP1/DHX9/TRIM27/BCL10 8 GO:0000469 cleavage involved in rRNA processing 1/982 27/18722 0.766769165339876 0.880746083772912 ERI2 1 GO:0007263 nitric oxide mediated signal transduction 1/982 27/18722 0.766769165339876 0.880746083772912 EGFR 1 GO:0009651 response to salt stress 1/982 27/18722 0.766769165339876 0.880746083772912 AKR1B1 1 GO:0010894 negative regulation of steroid biosynthetic process 1/982 27/18722 0.766769165339876 0.880746083772912 INSIG1 1 GO:0014850 response to muscle activity 1/982 27/18722 0.766769165339876 0.880746083772912 ADSL 1 GO:0016556 mRNA modification 1/982 27/18722 0.766769165339876 0.880746083772912 METTL3 1 GO:0018904 ether metabolic process 1/982 27/18722 0.766769165339876 0.880746083772912 CHPT1 1 GO:0032703 negative regulation of interleukin-2 production 1/982 27/18722 0.766769165339876 0.880746083772912 TRIM27 1 GO:0032967 positive regulation of collagen biosynthetic process 1/982 27/18722 0.766769165339876 0.880746083772912 VIM 1 GO:0035459 vesicle cargo loading 1/982 27/18722 0.766769165339876 0.880746083772912 INSIG1 1 GO:0042403 thyroid hormone metabolic process 1/982 27/18722 0.766769165339876 0.880746083772912 CPQ 1 GO:0042745 circadian sleep/wake cycle 1/982 27/18722 0.766769165339876 0.880746083772912 ADRB1 1 GO:0045830 positive regulation of isotype switching 1/982 27/18722 0.766769165339876 0.880746083772912 TFRC 1 GO:0046174 polyol catabolic process 1/982 27/18722 0.766769165339876 0.880746083772912 SYNJ1 1 GO:0046337 phosphatidylethanolamine metabolic process 1/982 27/18722 0.766769165339876 0.880746083772912 PISD 1 GO:0048520 positive regulation of behavior 1/982 27/18722 0.766769165339876 0.880746083772912 GJA1 1 GO:0048873 homeostasis of number of cells within a tissue 1/982 27/18722 0.766769165339876 0.880746083772912 FH 1 GO:0051953 negative regulation of amine transport 1/982 27/18722 0.766769165339876 0.880746083772912 SLC43A2 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/982 27/18722 0.766769165339876 0.880746083772912 PPARG 1 GO:0099625 ventricular cardiac muscle cell membrane repolarization 1/982 27/18722 0.766769165339876 0.880746083772912 GJA5 1 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 1/982 27/18722 0.766769165339876 0.880746083772912 SEMA6A 1 GO:1902914 regulation of protein polyubiquitination 1/982 27/18722 0.766769165339876 0.880746083772912 SKP2 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/982 27/18722 0.766769165339876 0.880746083772912 PINK1 1 GO:1903421 regulation of synaptic vesicle recycling 1/982 27/18722 0.766769165339876 0.880746083772912 CYFIP1 1 GO:0070555 response to interleukin-1 6/982 143/18722 0.767020677429774 0.880841006929481 APP/PRKCI/MAP3K7/CCL5/CYBA/RPS6KA4 6 GO:0071426 ribonucleoprotein complex export from nucleus 3/982 76/18722 0.768332837709309 0.881784871022179 ABCE1/LSG1/ENY2 3 GO:0032635 interleukin-6 production 7/982 165/18722 0.768370314484363 0.881784871022179 CD200/APP/ISL1/HLA-B/CYBA/DHX9/BCL10 7 GO:0032675 regulation of interleukin-6 production 7/982 165/18722 0.768370314484363 0.881784871022179 CD200/APP/ISL1/HLA-B/CYBA/DHX9/BCL10 7 GO:0006836 neurotransmitter transport 9/982 208/18722 0.76851879288091 0.881784871022179 SLC6A4/SYT7/SLC1A3/PPP1R9A/SLC29A1/SYNJ1/ITGB1/SLC38A2/NAPA 9 GO:0015837 amine transport 4/982 99/18722 0.769370300627355 0.882567734346225 SYT7/SLC43A2/PINK1/ITGB1 4 GO:0006302 double-strand break repair 11/982 251/18722 0.771045141559449 0.884294515913388 PARP2/POLQ/MCM2/BRCC3/FEN1/RMI2/MAGEF1/BRCA2/WDR48/RAD50/DDX1 11 GO:0045055 regulated exocytosis 10/982 230/18722 0.771856623457859 0.885030588691183 SCIN/SYT7/FER/TRPV6/SYNJ1/SNX4/RAB31/PDPK1/ANXA3/NAPA 10 GO:0050868 negative regulation of T cell activation 5/982 122/18722 0.773216099281321 0.88526563134586 SOCS6/PAWR/DLG5/TNFRSF21/GLI3 5 GO:0000280 nuclear division 20/982 439/18722 0.773733184085027 0.88526563134586 OBSL1/LRP5/BMP7/ASPM/CENPF/SMC2/P3H4/CHTF8/ZWINT/SPDL1/EPS8/RACGAP1/TOP2A/BRCA2/TPX2/KMT5A/CCNE1/KIF4A/LCMT1/RAD50 20 GO:0001541 ovarian follicle development 2/982 53/18722 0.774126209159475 0.88526563134586 MMP14/FOXC1 2 GO:0032210 regulation of telomere maintenance via telomerase 2/982 53/18722 0.774126209159475 0.88526563134586 PKIB/ATR 2 GO:0034381 plasma lipoprotein particle clearance 2/982 53/18722 0.774126209159475 0.88526563134586 LDLR/ANXA2 2 GO:0043113 receptor clustering 2/982 53/18722 0.774126209159475 0.88526563134586 PTN/GSN 2 GO:0043620 regulation of DNA-templated transcription in response to stress 2/982 53/18722 0.774126209159475 0.88526563134586 EPAS1/RBPJ 2 GO:0051438 regulation of ubiquitin-protein transferase activity 2/982 53/18722 0.774126209159475 0.88526563134586 PINK1/FEM1A 2 GO:0071320 cellular response to cAMP 2/982 53/18722 0.774126209159475 0.88526563134586 APP/ASS1 2 GO:0071715 icosanoid transport 2/982 53/18722 0.774126209159475 0.88526563134586 PTGES/PLA2G12A 2 GO:0097479 synaptic vesicle localization 2/982 53/18722 0.774126209159475 0.88526563134586 SYNJ1/PINK1 2 GO:0002200 somatic diversification of immune receptors 3/982 77/18722 0.775972050356448 0.88526563134586 TFRC/SWAP70/POLQ 3 GO:0071166 ribonucleoprotein complex localization 3/982 77/18722 0.775972050356448 0.88526563134586 ABCE1/LSG1/ENY2 3 GO:0140056 organelle localization by membrane tethering 3/982 77/18722 0.775972050356448 0.88526563134586 RAB13/CLN3/RABEPK 3 GO:0006626 protein targeting to mitochondrion 4/982 100/18722 0.776112297880154 0.88526563134586 LMAN1/PINK1/LEPROT/HUWE1 4 GO:0006641 triglyceride metabolic process 4/982 100/18722 0.776112297880154 0.88526563134586 GPAM/LDLR/PNPLA2/INSIG1 4 GO:0019218 regulation of steroid metabolic process 4/982 100/18722 0.776112297880154 0.88526563134586 ADM/LDLR/ACADVL/INSIG1 4 GO:0031396 regulation of protein ubiquitination 9/982 210/18722 0.777999149384917 0.88526563134586 SKP2/SOX4/WFS1/PINK1/WDR48/PTTG1IP/HUWE1/PHF23/BCL10 9 GO:0045637 regulation of myeloid cell differentiation 9/982 210/18722 0.777999149384917 0.88526563134586 FBN1/SCIN/CSF3R/UBASH3B/B2M/RCOR1/ESRRA/CDK6/NME1 9 GO:0003156 regulation of animal organ formation 1/982 28/18722 0.779020177890625 0.88526563134586 BMP7 1 GO:0007064 mitotic sister chromatid cohesion 1/982 28/18722 0.779020177890625 0.88526563134586 CHTF8 1 GO:0007141 male meiosis I 1/982 28/18722 0.779020177890625 0.88526563134586 BRCA2 1 GO:0009065 glutamine family amino acid catabolic process 1/982 28/18722 0.779020177890625 0.88526563134586 PPAT 1 GO:0010714 positive regulation of collagen metabolic process 1/982 28/18722 0.779020177890625 0.88526563134586 VIM 1 GO:0010818 T cell chemotaxis 1/982 28/18722 0.779020177890625 0.88526563134586 CCL5 1 GO:0010884 positive regulation of lipid storage 1/982 28/18722 0.779020177890625 0.88526563134586 HILPDA 1 GO:0019098 reproductive behavior 1/982 28/18722 0.779020177890625 0.88526563134586 APP 1 GO:0032438 melanosome organization 1/982 28/18722 0.779020177890625 0.88526563134586 RAB38 1 GO:0032607 interferon-alpha production 1/982 28/18722 0.779020177890625 0.88526563134586 DHX9 1 GO:0032647 regulation of interferon-alpha production 1/982 28/18722 0.779020177890625 0.88526563134586 DHX9 1 GO:0032958 inositol phosphate biosynthetic process 1/982 28/18722 0.779020177890625 0.88526563134586 P2RY6 1 GO:0034123 positive regulation of toll-like receptor signaling pathway 1/982 28/18722 0.779020177890625 0.88526563134586 CYBA 1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1/982 28/18722 0.779020177890625 0.88526563134586 EGFR 1 GO:0045589 regulation of regulatory T cell differentiation 1/982 28/18722 0.779020177890625 0.88526563134586 CD46 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/982 28/18722 0.779020177890625 0.88526563134586 LEPROT 1 GO:0060259 regulation of feeding behavior 1/982 28/18722 0.779020177890625 0.88526563134586 EIF2AK4 1 GO:0060325 face morphogenesis 1/982 28/18722 0.779020177890625 0.88526563134586 DLX5 1 GO:0071280 cellular response to copper ion 1/982 28/18722 0.779020177890625 0.88526563134586 APP 1 GO:0099623 regulation of cardiac muscle cell membrane repolarization 1/982 28/18722 0.779020177890625 0.88526563134586 GJA5 1 GO:1903649 regulation of cytoplasmic transport 1/982 28/18722 0.779020177890625 0.88526563134586 DAB2 1 GO:1990776 response to angiotensin 1/982 28/18722 0.779020177890625 0.88526563134586 CYBA 1 GO:0007215 glutamate receptor signaling pathway 2/982 54/18722 0.782984635378769 0.888609194546488 APP/CLN3 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/982 54/18722 0.782984635378769 0.888609194546488 P2RY6/PDPK1 2 GO:0010659 cardiac muscle cell apoptotic process 2/982 54/18722 0.782984635378769 0.888609194546488 NUPR1/PDPK1 2 GO:0051703 biological process involved in intraspecies interaction between organisms 2/982 54/18722 0.782984635378769 0.888609194546488 SLC6A4/SHANK2 2 GO:0070839 metal ion export 2/982 54/18722 0.782984635378769 0.888609194546488 ATP2B1/SLC40A1 2 GO:0072698 protein localization to microtubule cytoskeleton 2/982 54/18722 0.782984635378769 0.888609194546488 HOOK3/GOLGB1 2 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 3/982 78/18722 0.783403163940482 0.888890777270732 PPARG/BCL2L13/BAD 3 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 6/982 146/18722 0.783854379749295 0.889064119076958 LGR4/ADRB1/LGR5/ADGRG1/ADM/ADGRG6 6 GO:0006839 mitochondrial transport 11/982 254/18722 0.783896833518966 0.889064119076958 SLC25A13/LMAN1/SLC25A36/SLC25A4/SLC25A1/PINK1/AFG3L2/TST/LEPROT/BAD/HUWE1 11 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/982 168/18722 0.784079166874033 0.889077594438034 TFRC/B2M/CD46/HLA-B/HLA-A/MAP3K7/HLA-E 7 GO:0022613 ribonucleoprotein complex biogenesis 21/982 463/18722 0.784767067305094 0.889664208446722 CHD7/HEATR3/MAK16/NPM3/REXO4/ERI2/RPF2/YTHDF2/USP39/ABCE1/ATR/DHX9/RPL10/WDR43/PRPF39/LSG1/HEATR1/MPHOSPH10/DCAF13/SRPK1/DDX1 21 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 10/982 233/18722 0.785209603541728 0.88997246676959 LGR4/ADRB1/LGR5/GNA12/ADGRG1/GNAI1/ADM/GNA11/PSAP/ADGRG6 10 GO:0072594 establishment of protein localization to organelle 19/982 422/18722 0.785760478469723 0.89040335774453 CDH1/FERMT1/LMAN1/HEATR3/TRAM2/GLI3/TNPO1/TARDBP/PINK1/LMNA/NUP153/BRCA2/RANBP2/PTTG1IP/TRIM28/SCARB2/LEPROT/SEC63/HUWE1 19 GO:1903531 negative regulation of secretion by cell 6/982 147/18722 0.789256195483118 0.892681908667981 GJA1/CD200/FRMD4A/PPP1R9A/MAP4K4/ENY2 6 GO:0002360 T cell lineage commitment 1/982 29/18722 0.790628297357374 0.892681908667981 CTSL 1 GO:0007143 female meiotic nuclear division 1/982 29/18722 0.790628297357374 0.892681908667981 TOP2A 1 GO:0010458 exit from mitosis 1/982 29/18722 0.790628297357374 0.892681908667981 EPS8 1 GO:0019359 nicotinamide nucleotide biosynthetic process 1/982 29/18722 0.790628297357374 0.892681908667981 QPRT 1 GO:0019363 pyridine nucleotide biosynthetic process 1/982 29/18722 0.790628297357374 0.892681908667981 QPRT 1 GO:0019433 triglyceride catabolic process 1/982 29/18722 0.790628297357374 0.892681908667981 PNPLA2 1 GO:0031069 hair follicle morphogenesis 1/982 29/18722 0.790628297357374 0.892681908667981 FGFR2 1 GO:0033028 myeloid cell apoptotic process 1/982 29/18722 0.790628297357374 0.892681908667981 CTSL 1 GO:0042759 long-chain fatty acid biosynthetic process 1/982 29/18722 0.790628297357374 0.892681908667981 GSTP1 1 GO:0043153 entrainment of circadian clock by photoperiod 1/982 29/18722 0.790628297357374 0.892681908667981 NR2F6 1 GO:0048753 pigment granule organization 1/982 29/18722 0.790628297357374 0.892681908667981 RAB38 1 GO:0095500 acetylcholine receptor signaling pathway 1/982 29/18722 0.790628297357374 0.892681908667981 GNA11 1 GO:1900117 regulation of execution phase of apoptosis 1/982 29/18722 0.790628297357374 0.892681908667981 DFFA 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/982 29/18722 0.790628297357374 0.892681908667981 ANK3 1 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 1/982 29/18722 0.790628297357374 0.892681908667981 SEMA6A 1 GO:0000768 syncytium formation by plasma membrane fusion 2/982 55/18722 0.791536393326191 0.892681908667981 ERVW-1/MYOF 2 GO:0006360 transcription by RNA polymerase I 2/982 55/18722 0.791536393326191 0.892681908667981 WDR43/HEATR1 2 GO:0031113 regulation of microtubule polymerization 2/982 55/18722 0.791536393326191 0.892681908667981 MET/CAMSAP2 2 GO:0051898 negative regulation of protein kinase B signaling 2/982 55/18722 0.791536393326191 0.892681908667981 DAG1/PHLPP1 2 GO:0140253 cell-cell fusion 2/982 55/18722 0.791536393326191 0.892681908667981 ERVW-1/MYOF 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/982 55/18722 0.791536393326191 0.892681908667981 EFNA1/FLOT2 2 GO:0022898 regulation of transmembrane transporter activity 12/982 278/18722 0.795022001508923 0.896419100706992 GJA1/APP/TCAF1/WNK2/KCNG1/TMSB4X/FXYD3/P2RY6/PINK1/ITGB1/ANK3/EHD3 12 GO:0019233 sensory perception of pain 4/982 103/18722 0.79540587277519 0.896464354450171 MME/PTGES/COMT/NR2F6 4 GO:0030148 sphingolipid biosynthetic process 4/982 103/18722 0.79540587277519 0.896464354450171 PLPP3/DEGS1/HACD3/SPTLC3 4 GO:0032204 regulation of telomere maintenance 3/982 80/18722 0.797653914539495 0.898803806057033 PKIB/ATR/RAD50 3 GO:1902105 regulation of leukocyte differentiation 12/982 279/18722 0.798886123193483 0.898815051948505 FBN1/SOX4/UBASH3B/MMP14/CD46/HLA-B/GLI3/ESRRA/CDK6/METTL3/BAD/NME1 12 GO:0006687 glycosphingolipid metabolic process 2/982 56/18722 0.799789243825768 0.898815051948505 ITGB8/NEU1 2 GO:0046456 icosanoid biosynthetic process 2/982 56/18722 0.799789243825768 0.898815051948505 MGST3/PTGES 2 GO:0050433 regulation of catecholamine secretion 2/982 56/18722 0.799789243825768 0.898815051948505 SYT7/PINK1 2 GO:0002764 immune response-regulating signaling pathway 21/982 468/18722 0.800126597721173 0.898815051948505 LGR4/COLEC12/PAWR/FER/TNFRSF21/HLA-A/HRAS/SLC39A10/KCNN4/YES1/PTK2/MAP3K7/CD24/PUM1/ZCCHC3/CYBA/TSPAN6/PUM2/VAV3/PDPK1/BCL10 21 GO:0007601 visual perception 9/982 215/18722 0.800465854441279 0.898815051948505 TACSTD2/EFEMP1/EPAS1/MYO7A/CLDN19/RDH10/WFS1/TIMP3/KIFC3 9 GO:0014896 muscle hypertrophy 4/982 104/18722 0.801532049018964 0.898815051948505 PARP2/IL6ST/CYBA/LMNA 4 GO:0003299 muscle hypertrophy in response to stress 1/982 30/18722 0.80162722807984 0.898815051948505 LMNA 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/982 30/18722 0.80162722807984 0.898815051948505 APP 1 GO:0008209 androgen metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 ADM 1 GO:0009072 aromatic amino acid family metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 GSTZ1 1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/982 30/18722 0.80162722807984 0.898815051948505 CHD7 1 GO:0014887 cardiac muscle adaptation 1/982 30/18722 0.80162722807984 0.898815051948505 LMNA 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/982 30/18722 0.80162722807984 0.898815051948505 LMNA 1 GO:0019674 NAD metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 QPRT 1 GO:0031365 N-terminal protein amino acid modification 1/982 30/18722 0.80162722807984 0.898815051948505 SOX4 1 GO:0043032 positive regulation of macrophage activation 1/982 30/18722 0.80162722807984 0.898815051948505 CEBPA 1 GO:0044788 modulation by host of viral process 1/982 30/18722 0.80162722807984 0.898815051948505 EIF2AK4 1 GO:0045939 negative regulation of steroid metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 INSIG1 1 GO:0045940 positive regulation of steroid metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 ADM 1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 1/982 30/18722 0.80162722807984 0.898815051948505 PAWR 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/982 30/18722 0.80162722807984 0.898815051948505 EGFR 1 GO:1903579 negative regulation of ATP metabolic process 1/982 30/18722 0.80162722807984 0.898815051948505 NUPR1 1 GO:0006096 glycolytic process 3/982 81/18722 0.804480231185543 0.901432628542169 APP/NUPR1/DHTKD1 3 GO:0008589 regulation of smoothened signaling pathway 3/982 81/18722 0.804480231185543 0.901432628542169 FGFR2/DLG5/GLI3 3 GO:0010833 telomere maintenance via telomere lengthening 3/982 81/18722 0.804480231185543 0.901432628542169 PKIB/ATR/RAD50 3 GO:0034765 regulation of ion transmembrane transport 22/982 491/18722 0.806815622182662 0.903855301826625 APP/GJA5/TCAF1/UBASH3B/GPR89A/WNK2/KCNG1/CHD7/SLC43A2/TMSB4X/FXYD3/TSPAN13/KCNN4/P2RY6/CYBA/PINK1/TMEM37/ITGB1/ANK3/CLIC4/EHD3/PDPK1 22 GO:0006639 acylglycerol metabolic process 5/982 128/18722 0.807683753256441 0.90432047679234 ABHD12/GPAM/LDLR/PNPLA2/INSIG1 5 GO:0016447 somatic recombination of immunoglobulin gene segments 2/982 57/18722 0.807750978024446 0.90432047679234 TFRC/SWAP70 2 GO:0061756 leukocyte adhesion to vascular endothelial cell 2/982 57/18722 0.807750978024446 0.90432047679234 NFAT5/ITGB1 2 GO:0006757 ATP generation from ADP 3/982 82/18722 0.811111780922311 0.904473010885397 APP/NUPR1/DHTKD1 3 GO:0008543 fibroblast growth factor receptor signaling pathway 3/982 82/18722 0.811111780922311 0.904473010885397 FGFR2/GPC1/KIF16B 3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 3/982 82/18722 0.811111780922311 0.904473010885397 TIMP3/ZDHHC3/BAD 3 GO:0050000 chromosome localization 3/982 82/18722 0.811111780922311 0.904473010885397 CENPF/SPDL1/LMNA 3 GO:0044270 cellular nitrogen compound catabolic process 20/982 451/18722 0.811325175617473 0.904473010885397 KCNQ1OT1/LIN28B/AXIN2/NUDT4/PUM1/REXO4/TET2/QPRT/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/PDE7A/TST/VIM/DFFA 20 GO:0001516 prostaglandin biosynthetic process 1/982 31/18722 0.812048909121226 0.904473010885397 PTGES 1 GO:0001782 B cell homeostasis 1/982 31/18722 0.812048909121226 0.904473010885397 BCL10 1 GO:0006301 postreplication repair 1/982 31/18722 0.812048909121226 0.904473010885397 USP43 1 GO:0030149 sphingolipid catabolic process 1/982 31/18722 0.812048909121226 0.904473010885397 NEU1 1 GO:0031063 regulation of histone deacetylation 1/982 31/18722 0.812048909121226 0.904473010885397 PINK1 1 GO:0032509 endosome transport via multivesicular body sorting pathway 1/982 31/18722 0.812048909121226 0.904473010885397 LEPROT 1 GO:0036475 neuron death in response to oxidative stress 1/982 31/18722 0.812048909121226 0.904473010885397 PINK1 1 GO:0045066 regulatory T cell differentiation 1/982 31/18722 0.812048909121226 0.904473010885397 CD46 1 GO:0045987 positive regulation of smooth muscle contraction 1/982 31/18722 0.812048909121226 0.904473010885397 CTTN 1 GO:0046457 prostanoid biosynthetic process 1/982 31/18722 0.812048909121226 0.904473010885397 PTGES 1 GO:0050482 arachidonic acid secretion 1/982 31/18722 0.812048909121226 0.904473010885397 PLA2G12A 1 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1/982 31/18722 0.812048909121226 0.904473010885397 PINK1 1 GO:0051569 regulation of histone H3-K4 methylation 1/982 31/18722 0.812048909121226 0.904473010885397 DNMT1 1 GO:0055075 potassium ion homeostasis 1/982 31/18722 0.812048909121226 0.904473010885397 ATP6V1B1 1 GO:0060055 angiogenesis involved in wound healing 1/982 31/18722 0.812048909121226 0.904473010885397 DAG1 1 GO:0070528 protein kinase C signaling 1/982 31/18722 0.812048909121226 0.904473010885397 ADGRG1 1 GO:1903963 arachidonate transport 1/982 31/18722 0.812048909121226 0.904473010885397 PLA2G12A 1 GO:1905144 response to acetylcholine 1/982 31/18722 0.812048909121226 0.904473010885397 GNA11 1 GO:1905145 cellular response to acetylcholine 1/982 31/18722 0.812048909121226 0.904473010885397 GNA11 1 GO:0006638 neutral lipid metabolic process 5/982 129/18722 0.813002962376915 0.905149082552399 ABHD12/GPAM/LDLR/PNPLA2/INSIG1 5 GO:0007127 meiosis I 5/982 129/18722 0.813002962376915 0.905149082552399 P3H4/TOP2A/BRCA2/CCNE1/RAD50 5 GO:2000278 regulation of DNA biosynthetic process 4/982 106/18722 0.813338178949537 0.905329052795728 GJA1/CHTF8/PKIB/ATR 4 GO:0032886 regulation of microtubule-based process 10/982 240/18722 0.814149634211042 0.905723959390003 MET/EFNA5/GNAI1/KLHL42/HDAC6/CAMSAP2/CLTC/TRIM37/PLK2/TPX2 10 GO:0050871 positive regulation of B cell activation 6/982 152/18722 0.814726436634042 0.905723959390003 TFRC/MMP14/SLC39A10/VAV3/IRS2/BAD 6 GO:0002931 response to ischemia 2/982 58/18722 0.815429392886398 0.905723959390003 GJA1/PINK1 2 GO:0007131 reciprocal meiotic recombination 2/982 58/18722 0.815429392886398 0.905723959390003 TOP2A/RAD50 2 GO:0010043 response to zinc ion 2/982 58/18722 0.815429392886398 0.905723959390003 ALAD/ASS1 2 GO:0010574 regulation of vascular endothelial growth factor production 2/982 58/18722 0.815429392886398 0.905723959390003 ISL1/IL6ST 2 GO:0032481 positive regulation of type I interferon production 2/982 58/18722 0.815429392886398 0.905723959390003 ZCCHC3/DHX9 2 GO:0043666 regulation of phosphoprotein phosphatase activity 2/982 58/18722 0.815429392886398 0.905723959390003 SLC39A10/HSP90B1 2 GO:0050432 catecholamine secretion 2/982 58/18722 0.815429392886398 0.905723959390003 SYT7/PINK1 2 GO:0140527 reciprocal homologous recombination 2/982 58/18722 0.815429392886398 0.905723959390003 TOP2A/RAD50 2 GO:0050953 sensory perception of light stimulus 9/982 219/18722 0.817187551414028 0.907483557201527 TACSTD2/EFEMP1/EPAS1/MYO7A/CLDN19/RDH10/WFS1/TIMP3/KIFC3 9 GO:0046785 microtubule polymerization 3/982 83/18722 0.817552113266654 0.907501983996354 MET/CAMSAP2/TPX2 3 GO:0050672 negative regulation of lymphocyte proliferation 3/982 83/18722 0.817552113266654 0.907501983996354 PAWR/DLG5/TNFRSF21 3 GO:0050864 regulation of B cell activation 8/982 198/18722 0.821179315579303 0.909299388980805 TFRC/PAWR/MMP14/TNFRSF21/SLC39A10/VAV3/IRS2/BAD 8 GO:1903320 regulation of protein modification by small protein conjugation or removal 10/982 242/18722 0.821856982485244 0.909299388980805 SKP2/SOX4/EPAS1/WFS1/PINK1/WDR48/PTTG1IP/HUWE1/PHF23/BCL10 10 GO:0003180 aortic valve morphogenesis 1/982 32/18722 0.821923606635696 0.909299388980805 EFNA1 1 GO:0019228 neuronal action potential 1/982 32/18722 0.821923606635696 0.909299388980805 ANK3 1 GO:0032196 transposition 1/982 32/18722 0.821923606635696 0.909299388980805 L1TD1 1 GO:0035456 response to interferon-beta 1/982 32/18722 0.821923606635696 0.909299388980805 TRIM6 1 GO:0042044 fluid transport 1/982 32/18722 0.821923606635696 0.909299388980805 EXT2 1 GO:0042219 cellular modified amino acid catabolic process 1/982 32/18722 0.821923606635696 0.909299388980805 ABHD12 1 GO:0045761 regulation of adenylate cyclase activity 1/982 32/18722 0.821923606635696 0.909299388980805 NF1 1 GO:0045879 negative regulation of smoothened signaling pathway 1/982 32/18722 0.821923606635696 0.909299388980805 GLI3 1 GO:0060323 head morphogenesis 1/982 32/18722 0.821923606635696 0.909299388980805 DLX5 1 GO:0061036 positive regulation of cartilage development 1/982 32/18722 0.821923606635696 0.909299388980805 GLI3 1 GO:0061037 negative regulation of cartilage development 1/982 32/18722 0.821923606635696 0.909299388980805 EFEMP1 1 GO:0071875 adrenergic receptor signaling pathway 1/982 32/18722 0.821923606635696 0.909299388980805 ADRB1 1 GO:0002820 negative regulation of adaptive immune response 2/982 59/18722 0.822832269169747 0.909299388980805 CD46/TRIM27 2 GO:0019369 arachidonic acid metabolic process 2/982 59/18722 0.822832269169747 0.909299388980805 ABHD12/CYP2J2 2 GO:0035306 positive regulation of dephosphorylation 2/982 59/18722 0.822832269169747 0.909299388980805 SLC39A10/PINK1 2 GO:0051353 positive regulation of oxidoreductase activity 2/982 59/18722 0.822832269169747 0.909299388980805 PDP2/CYBA 2 GO:0051568 histone H3-K4 methylation 2/982 59/18722 0.822832269169747 0.909299388980805 TET2/DNMT1 2 GO:0071806 protein transmembrane transport 2/982 59/18722 0.822832269169747 0.909299388980805 TRAM2/SEC63 2 GO:2000351 regulation of endothelial cell apoptotic process 2/982 59/18722 0.822832269169747 0.909299388980805 PRKCI/PDPK1 2 GO:0018022 peptidyl-lysine methylation 5/982 131/18722 0.823288033608505 0.909603311819951 BRD4/TET2/LMNA/DNMT1/KMT5A 5 GO:0006405 RNA export from nucleus 3/982 84/18722 0.823804839922824 0.909603311819951 DHX9/NUP153/ENY2 3 GO:0015844 monoamine transport 3/982 84/18722 0.823804839922824 0.909603311819951 SLC6A4/SYT7/PINK1 3 GO:0032945 negative regulation of mononuclear cell proliferation 3/982 84/18722 0.823804839922824 0.909603311819951 PAWR/DLG5/TNFRSF21 3 GO:0071466 cellular response to xenobiotic stimulus 7/982 177/18722 0.82641401770499 0.911489696729276 EGFR/TFRC/CYP2J2/GSTP1/PPAT/GSTA4/NME1 7 GO:0046434 organophosphate catabolic process 6/982 155/18722 0.828808316611308 0.911489696729276 ABHD12/LDLR/SYNJ1/NUDT4/IDH1/PDE7A 6 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 3/982 85/18722 0.829873623866582 0.911489696729276 ISL1/IL6ST/CCL5 3 GO:0071277 cellular response to calcium ion 3/982 85/18722 0.829873623866582 0.911489696729276 SYT7/LGMN/CLIC4 3 GO:0097194 execution phase of apoptosis 3/982 85/18722 0.829873623866582 0.911489696729276 BLCAP/TOP2A/DFFA 3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 2/982 60/18722 0.829967351693151 0.911489696729276 MBNL3/MBNL2 2 GO:0019731 antibacterial humoral response 2/982 60/18722 0.829967351693151 0.911489696729276 HLA-A/HLA-E 2 GO:0031663 lipopolysaccharide-mediated signaling pathway 2/982 60/18722 0.829967351693151 0.911489696729276 CCL5/BCL10 2 GO:0035825 homologous recombination 2/982 60/18722 0.829967351693151 0.911489696729276 TOP2A/RAD50 2 GO:0001975 response to amphetamine 1/982 33/18722 0.831280001407432 0.911489696729276 RANBP2 1 GO:0006336 DNA replication-independent nucleosome assembly 1/982 33/18722 0.831280001407432 0.911489696729276 CENPW 1 GO:0006536 glutamate metabolic process 1/982 33/18722 0.831280001407432 0.911489696729276 GCLM 1 GO:0009648 photoperiodism 1/982 33/18722 0.831280001407432 0.911489696729276 NR2F6 1 GO:0010737 protein kinase A signaling 1/982 33/18722 0.831280001407432 0.911489696729276 RAB13 1 GO:0010984 regulation of lipoprotein particle clearance 1/982 33/18722 0.831280001407432 0.911489696729276 ANXA2 1 GO:0018345 protein palmitoylation 1/982 33/18722 0.831280001407432 0.911489696729276 ZDHHC3 1 GO:0019362 pyridine nucleotide metabolic process 1/982 33/18722 0.831280001407432 0.911489696729276 QPRT 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/982 33/18722 0.831280001407432 0.911489696729276 EPN2 1 GO:0031116 positive regulation of microtubule polymerization 1/982 33/18722 0.831280001407432 0.911489696729276 MET 1 GO:0032633 interleukin-4 production 1/982 33/18722 0.831280001407432 0.911489696729276 HLA-E 1 GO:0032673 regulation of interleukin-4 production 1/982 33/18722 0.831280001407432 0.911489696729276 HLA-E 1 GO:0033198 response to ATP 1/982 33/18722 0.831280001407432 0.911489696729276 HSP90B1 1 GO:0046496 nicotinamide nucleotide metabolic process 1/982 33/18722 0.831280001407432 0.911489696729276 QPRT 1 GO:0048730 epidermis morphogenesis 1/982 33/18722 0.831280001407432 0.911489696729276 FGFR2 1 GO:0050901 leukocyte tethering or rolling 1/982 33/18722 0.831280001407432 0.911489696729276 ITGB1 1 GO:0071763 nuclear membrane organization 1/982 33/18722 0.831280001407432 0.911489696729276 TARDBP 1 GO:0099174 regulation of presynapse organization 1/982 33/18722 0.831280001407432 0.911489696729276 APP 1 GO:1901099 negative regulation of signal transduction in absence of ligand 1/982 33/18722 0.831280001407432 0.911489696729276 IFI6 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/982 33/18722 0.831280001407432 0.911489696729276 ANK3 1 GO:1901976 regulation of cell cycle checkpoint 1/982 33/18722 0.831280001407432 0.911489696729276 LCMT1 1 GO:1902992 negative regulation of amyloid precursor protein catabolic process 1/982 33/18722 0.831280001407432 0.911489696729276 FLOT2 1 GO:1905606 regulation of presynapse assembly 1/982 33/18722 0.831280001407432 0.911489696729276 APP 1 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/982 33/18722 0.831280001407432 0.911489696729276 IFI6 1 GO:0006814 sodium ion transport 10/982 245/18722 0.832960181514265 0.913140039255655 SLC6A4/ATP6V1B1/WNK2/PRSS8/FXYD3/SLC13A3/PKP2/SLC38A2/ANK3/SLC5A3 10 GO:0032412 regulation of ion transmembrane transporter activity 11/982 267/18722 0.833610518890285 0.913660951151865 APP/TCAF1/WNK2/KCNG1/TMSB4X/FXYD3/P2RY6/PINK1/ITGB1/ANK3/EHD3 11 GO:0032611 interleukin-1 beta production 4/982 110/18722 0.835223053654455 0.914968780784225 APP/ISL1/GSTP1/NLRP2 4 GO:0032651 regulation of interleukin-1 beta production 4/982 110/18722 0.835223053654455 0.914968780784225 APP/ISL1/GSTP1/NLRP2 4 GO:0022406 membrane docking 3/982 86/18722 0.835762169120004 0.914968780784225 RAB13/CLN3/RABEPK 3 GO:0045921 positive regulation of exocytosis 3/982 86/18722 0.835762169120004 0.914968780784225 SYT7/SNX4/EXPH5 3 GO:0019748 secondary metabolic process 2/982 61/18722 0.836842331713032 0.914968780784225 AKR1B1/OPN3 2 GO:0042255 ribosome assembly 2/982 61/18722 0.836842331713032 0.914968780784225 RPF2/RPL10 2 GO:1904356 regulation of telomere maintenance via telomere lengthening 2/982 61/18722 0.836842331713032 0.914968780784225 PKIB/ATR 2 GO:1905515 non-motile cilium assembly 2/982 61/18722 0.836842331713032 0.914968780784225 IFT74/CEP135 2 GO:1903046 meiotic cell cycle process 8/982 202/18722 0.837293361207205 0.914968780784225 ASPM/SMC2/P3H4/YTHDF2/TOP2A/BRCA2/CCNE1/RAD50 8 GO:0002446 neutrophil mediated immunity 1/982 34/18722 0.840145271813441 0.914968780784225 ANXA3 1 GO:0010614 negative regulation of cardiac muscle hypertrophy 1/982 34/18722 0.840145271813441 0.914968780784225 LMNA 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/982 34/18722 0.840145271813441 0.914968780784225 PPARG 1 GO:0010922 positive regulation of phosphatase activity 1/982 34/18722 0.840145271813441 0.914968780784225 SLC39A10 1 GO:0014072 response to isoquinoline alkaloid 1/982 34/18722 0.840145271813441 0.914968780784225 MDM2 1 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/982 34/18722 0.840145271813441 0.914968780784225 CHD7 1 GO:0030851 granulocyte differentiation 1/982 34/18722 0.840145271813441 0.914968780784225 CEBPA 1 GO:0032743 positive regulation of interleukin-2 production 1/982 34/18722 0.840145271813441 0.914968780784225 MAP3K7 1 GO:0034724 DNA replication-independent nucleosome organization 1/982 34/18722 0.840145271813441 0.914968780784225 CENPW 1 GO:0035308 negative regulation of protein dephosphorylation 1/982 34/18722 0.840145271813441 0.914968780784225 SWAP70 1 GO:0035590 purinergic nucleotide receptor signaling pathway 1/982 34/18722 0.840145271813441 0.914968780784225 P2RY6 1 GO:0042573 retinoic acid metabolic process 1/982 34/18722 0.840145271813441 0.914968780784225 RDH10 1 GO:0043278 response to morphine 1/982 34/18722 0.840145271813441 0.914968780784225 MDM2 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/982 34/18722 0.840145271813441 0.914968780784225 ITGAV 1 GO:0048536 spleen development 1/982 34/18722 0.840145271813441 0.914968780784225 PBX1 1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 1/982 34/18722 0.840145271813441 0.914968780784225 TGM2 1 GO:0051973 positive regulation of telomerase activity 1/982 34/18722 0.840145271813441 0.914968780784225 PKIB 1 GO:0070050 neuron cellular homeostasis 1/982 34/18722 0.840145271813441 0.914968780784225 ATP2B1 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/982 34/18722 0.840145271813441 0.914968780784225 NFAT5 1 GO:0090075 relaxation of muscle 1/982 34/18722 0.840145271813441 0.914968780784225 GSN 1 GO:2000352 negative regulation of endothelial cell apoptotic process 1/982 34/18722 0.840145271813441 0.914968780784225 PDPK1 1 GO:0008037 cell recognition 9/982 225/18722 0.840241652599011 0.914968780784225 COLEC12/SPESP1/APP/CADM1/NRP1/FOLR1/TNFRSF21/LY6K/BSG 9 GO:0019646 aerobic electron transport chain 3/982 87/18722 0.84147421118938 0.916119700597747 CYC1/PINK1/COX6A1 3 GO:0009581 detection of external stimulus 5/982 135/18722 0.842484439624679 0.916183373546924 CDS1/GNA11/PTK2/NR2F6/OPN3 5 GO:0061982 meiosis I cell cycle process 5/982 135/18722 0.842484439624679 0.916183373546924 P3H4/TOP2A/BRCA2/CCNE1/RAD50 5 GO:0032640 tumor necrosis factor production 7/982 181/18722 0.843009761046858 0.916183373546924 APP/ISL1/HLA-E/CYBA/GSTP1/DHX9/TRIM27 7 GO:0032680 regulation of tumor necrosis factor production 7/982 181/18722 0.843009761046858 0.916183373546924 APP/ISL1/HLA-E/CYBA/GSTP1/DHX9/TRIM27 7 GO:0031124 mRNA 3'-end processing 2/982 62/18722 0.843464831244695 0.916183373546924 APP/CSTF1 2 GO:0032613 interleukin-10 production 2/982 62/18722 0.843464831244695 0.916183373546924 TNFRSF21/CD46 2 GO:0032615 interleukin-12 production 2/982 62/18722 0.843464831244695 0.916183373546924 ISL1/HLA-B 2 GO:0032623 interleukin-2 production 2/982 62/18722 0.843464831244695 0.916183373546924 MAP3K7/TRIM27 2 GO:0032653 regulation of interleukin-10 production 2/982 62/18722 0.843464831244695 0.916183373546924 TNFRSF21/CD46 2 GO:0032655 regulation of interleukin-12 production 2/982 62/18722 0.843464831244695 0.916183373546924 ISL1/HLA-B 2 GO:0032663 regulation of interleukin-2 production 2/982 62/18722 0.843464831244695 0.916183373546924 MAP3K7/TRIM27 2 GO:0032609 interferon-gamma production 4/982 112/18722 0.845336556182157 0.916548274900499 ISL1/HLA-A/HRAS/TRIM27 4 GO:0032649 regulation of interferon-gamma production 4/982 112/18722 0.845336556182157 0.916548274900499 ISL1/HLA-A/HRAS/TRIM27 4 GO:0032200 telomere organization 6/982 159/18722 0.846239201525832 0.916548274900499 FEN1/PKIB/ATR/BRCA2/CCNE1/RAD50 6 GO:1903305 regulation of regulated secretory pathway 5/982 136/18722 0.847006064924428 0.916548274900499 SYT7/FER/TRPV6/SNX4/PDPK1 5 GO:0030101 natural killer cell activation 3/982 88/18722 0.847013508138884 0.916548274900499 PBX1/HLA-E/PRDX1 3 GO:0002768 immune response-regulating cell surface receptor signaling pathway 13/982 315/18722 0.848357173523575 0.916548274900499 PAWR/FER/TNFRSF21/HLA-A/HRAS/SLC39A10/KCNN4/YES1/PTK2/MAP3K7/CD24/VAV3/BCL10 13 GO:0003298 physiological muscle hypertrophy 1/982 35/18722 0.8485451724491 0.916548274900499 PARP2 1 GO:0003301 physiological cardiac muscle hypertrophy 1/982 35/18722 0.8485451724491 0.916548274900499 PARP2 1 GO:0003351 epithelial cilium movement involved in extracellular fluid movement 1/982 35/18722 0.8485451724491 0.916548274900499 NPHP3 1 GO:0006298 mismatch repair 1/982 35/18722 0.8485451724491 0.916548274900499 AXIN2 1 GO:0006471 protein ADP-ribosylation 1/982 35/18722 0.8485451724491 0.916548274900499 PARP2 1 GO:0006691 leukotriene metabolic process 1/982 35/18722 0.8485451724491 0.916548274900499 MGST3 1 GO:0007020 microtubule nucleation 1/982 35/18722 0.8485451724491 0.916548274900499 TPX2 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/982 35/18722 0.8485451724491 0.916548274900499 RACGAP1 1 GO:0009119 ribonucleoside metabolic process 1/982 35/18722 0.8485451724491 0.916548274900499 ADK 1 GO:0032205 negative regulation of telomere maintenance 1/982 35/18722 0.8485451724491 0.916548274900499 RAD50 1 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1/982 35/18722 0.8485451724491 0.916548274900499 USP14 1 GO:0032814 regulation of natural killer cell activation 1/982 35/18722 0.8485451724491 0.916548274900499 HLA-E 1 GO:0043243 positive regulation of protein-containing complex disassembly 1/982 35/18722 0.8485451724491 0.916548274900499 IGF1R 1 GO:0045880 positive regulation of smoothened signaling pathway 1/982 35/18722 0.8485451724491 0.916548274900499 DLG5 1 GO:0046471 phosphatidylglycerol metabolic process 1/982 35/18722 0.8485451724491 0.916548274900499 GPAM 1 GO:0046627 negative regulation of insulin receptor signaling pathway 1/982 35/18722 0.8485451724491 0.916548274900499 KANK1 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/982 35/18722 0.8485451724491 0.916548274900499 PARP2 1 GO:0106056 regulation of calcineurin-mediated signaling 1/982 35/18722 0.8485451724491 0.916548274900499 NFAT5 1 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1/982 35/18722 0.8485451724491 0.916548274900499 CHD7 1 GO:1905207 regulation of cardiocyte differentiation 1/982 35/18722 0.8485451724491 0.916548274900499 EGFR 1 GO:1905898 positive regulation of response to endoplasmic reticulum stress 1/982 35/18722 0.8485451724491 0.916548274900499 TMEM33 1 GO:0045143 homologous chromosome segregation 2/982 63/18722 0.849842389172259 0.917189716929961 P3H4/CCNE1 2 GO:0046902 regulation of mitochondrial membrane permeability 2/982 63/18722 0.849842389172259 0.917189716929961 SLC25A4/BAD 2 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 2/982 63/18722 0.849842389172259 0.917189716929961 WFS1/CREB3 2 GO:0099601 regulation of neurotransmitter receptor activity 2/982 63/18722 0.849842389172259 0.917189716929961 APP/PINK1 2 GO:0060078 regulation of postsynaptic membrane potential 5/982 137/18722 0.851419820792664 0.918702065629817 ADRB1/APP/GABRE/PPP1R9A/SLC29A1 5 GO:0046700 heterocycle catabolic process 19/982 445/18722 0.852260624707555 0.91936188360954 KCNQ1OT1/LIN28B/AXIN2/NUDT4/PUM1/REXO4/TET2/QPRT/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/PDE7A/VIM/DFFA 19 GO:0046330 positive regulation of JNK cascade 3/982 89/18722 0.852383832272955 0.91936188360954 APP/TRAF4/HRAS 3 GO:0019439 aromatic compound catabolic process 20/982 467/18722 0.854225761956149 0.920906626376337 KCNQ1OT1/LIN28B/AXIN2/NUDT4/COMT/GSTZ1/PUM1/REXO4/TET2/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/PDE7A/VIM/DFFA 20 GO:0022904 respiratory electron transport chain 4/982 114/18722 0.854921674099949 0.920906626376337 SLC25A13/CYC1/PINK1/COX6A1 4 GO:0009582 detection of abiotic stimulus 5/982 138/18722 0.855727314962277 0.920906626376337 CDS1/GNA11/PTK2/NR2F6/OPN3 5 GO:0006940 regulation of smooth muscle contraction 2/982 64/18722 0.855982449003187 0.920906626376337 CTTN/ATP2B1 2 GO:0048857 neural nucleus development 2/982 64/18722 0.855982449003187 0.920906626376337 NFIB/BASP1 2 GO:0002691 regulation of cellular extravasation 1/982 36/18722 0.856504108642978 0.920906626376337 JAM3 1 GO:0006699 bile acid biosynthetic process 1/982 36/18722 0.856504108642978 0.920906626376337 SLC27A2 1 GO:0014741 negative regulation of muscle hypertrophy 1/982 36/18722 0.856504108642978 0.920906626376337 LMNA 1 GO:0038179 neurotrophin signaling pathway 1/982 36/18722 0.856504108642978 0.920906626376337 CYFIP1 1 GO:0043949 regulation of cAMP-mediated signaling 1/982 36/18722 0.856504108642978 0.920906626376337 GNAI1 1 GO:0045191 regulation of isotype switching 1/982 36/18722 0.856504108642978 0.920906626376337 TFRC 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/982 36/18722 0.856504108642978 0.920906626376337 BCAR3 1 GO:0051354 negative regulation of oxidoreductase activity 1/982 36/18722 0.856504108642978 0.920906626376337 HDAC6 1 GO:0086010 membrane depolarization during action potential 1/982 36/18722 0.856504108642978 0.920906626376337 ANK3 1 GO:0097009 energy homeostasis 1/982 36/18722 0.856504108642978 0.920906626376337 TSKU 1 GO:0006417 regulation of translation 20/982 468/18722 0.856640903216639 0.920906626376337 APP/SOX4/IGF2BP3/ACO1/EIF2AK4/CYFIP1/PLXNB2/PUM1/TARDBP/YTHDF2/CCL5/PINK1/PUM2/ABCE1/DHX9/METTL3/UPF3A/RPL10/VIM/DDX1 20 GO:1903131 mononuclear cell differentiation 18/982 426/18722 0.857969934834684 0.922145308077006 PBX1/SOX4/GPR89A/PTPRK/MMP14/PPARG/ITGB8/CHD7/B2M/CTSL/CD46/HLA-B/GLI3/CDK6/ITGB1/METTL3/BAD/RBPJ 18 GO:0140013 meiotic nuclear division 7/982 185/18722 0.8583111487381 0.922165739661614 ASPM/SMC2/P3H4/TOP2A/BRCA2/CCNE1/RAD50 7 GO:0051100 negative regulation of binding 6/982 162/18722 0.858342535670463 0.922165739661614 B2M/ID1/TMSB4X/DAB2/PTPRF/ZNF593 6 GO:0046513 ceramide biosynthetic process 2/982 65/18722 0.861892348133423 0.9235045395486 DEGS1/SPTLC3 2 GO:0051310 metaphase plate congression 2/982 65/18722 0.861892348133423 0.9235045395486 CENPF/SPDL1 2 GO:0072577 endothelial cell apoptotic process 2/982 65/18722 0.861892348133423 0.9235045395486 PRKCI/PDPK1 2 GO:0098661 inorganic anion transmembrane transport 3/982 91/18722 0.862632676656491 0.9235045395486 SLC26A2/GABRE/SLC1A3 3 GO:0034655 nucleobase-containing compound catabolic process 17/982 407/18722 0.863940114064201 0.9235045395486 KCNQ1OT1/LIN28B/AXIN2/NUDT4/PUM1/REXO4/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/PDE7A/VIM/DFFA 17 GO:0007006 mitochondrial membrane organization 4/982 116/18722 0.863997136763963 0.9235045395486 SLC25A4/PINK1/AFG3L2/BAD 4 GO:0031123 RNA 3'-end processing 4/982 116/18722 0.863997136763963 0.9235045395486 APP/LIN28B/ERI2/CSTF1 4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1/982 37/18722 0.864045207075633 0.9235045395486 UPF3A 1 GO:0003016 respiratory system process 1/982 37/18722 0.864045207075633 0.9235045395486 GAA 1 GO:0006623 protein targeting to vacuole 1/982 37/18722 0.864045207075633 0.9235045395486 SCARB2 1 GO:0007340 acrosome reaction 1/982 37/18722 0.864045207075633 0.9235045395486 SPESP1 1 GO:0016202 regulation of striated muscle tissue development 1/982 37/18722 0.864045207075633 0.9235045395486 CENPF 1 GO:0021532 neural tube patterning 1/982 37/18722 0.864045207075633 0.9235045395486 GLI3 1 GO:0030513 positive regulation of BMP signaling pathway 1/982 37/18722 0.864045207075633 0.9235045395486 RBPJ 1 GO:0031112 positive regulation of microtubule polymerization or depolymerization 1/982 37/18722 0.864045207075633 0.9235045395486 MET 1 GO:0033363 secretory granule organization 1/982 37/18722 0.864045207075633 0.9235045395486 RAB38 1 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 1/982 37/18722 0.864045207075633 0.9235045395486 GPC1 1 GO:0042178 xenobiotic catabolic process 1/982 37/18722 0.864045207075633 0.9235045395486 CYP2J2 1 GO:0043368 positive T cell selection 1/982 37/18722 0.864045207075633 0.9235045395486 CTSL 1 GO:0060306 regulation of membrane repolarization 1/982 37/18722 0.864045207075633 0.9235045395486 GJA5 1 GO:0071542 dopaminergic neuron differentiation 1/982 37/18722 0.864045207075633 0.9235045395486 LRP6 1 GO:0072529 pyrimidine-containing compound catabolic process 1/982 37/18722 0.864045207075633 0.9235045395486 TET2 1 GO:0097484 dendrite extension 1/982 37/18722 0.864045207075633 0.9235045395486 CYFIP1 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/982 37/18722 0.864045207075633 0.9235045395486 CHID1 1 GO:1900077 negative regulation of cellular response to insulin stimulus 1/982 37/18722 0.864045207075633 0.9235045395486 KANK1 1 GO:0006402 mRNA catabolic process 9/982 232/18722 0.864192035570689 0.9235045395486 AXIN2/PUM1/TARDBP/YTHDF2/PUM2/DHX9/METTL3/UPF3A/VIM 9 GO:0032465 regulation of cytokinesis 3/982 92/18722 0.867518745850007 0.925796577972337 RACGAP1/PLK2/BRCA2 3 GO:0034502 protein localization to chromosome 3/982 92/18722 0.867518745850007 0.925796577972337 SPDL1/ATR/BRCA2 3 GO:0070509 calcium ion import 3/982 92/18722 0.867518745850007 0.925796577972337 TRPV6/AFG3L2/TRIM27 3 GO:1903312 negative regulation of mRNA metabolic process 3/982 92/18722 0.867518745850007 0.925796577972337 AXIN2/TARDBP/DHX9 3 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 2/982 66/18722 0.867579308498616 0.925796577972337 TFRC/SWAP70 2 GO:0016444 somatic cell DNA recombination 2/982 66/18722 0.867579308498616 0.925796577972337 TFRC/SWAP70 2 GO:0046626 regulation of insulin receptor signaling pathway 2/982 66/18722 0.867579308498616 0.925796577972337 KANK1/SORBS1 2 GO:0016571 histone methylation 5/982 141/18722 0.868028617634749 0.925897192143733 BRD4/TET2/LMNA/DNMT1/KMT5A 5 GO:0034341 response to interferon-gamma 5/982 141/18722 0.868028617634749 0.925897192143733 PPARG/CCL5/FLNB/VIM/ASS1 5 GO:0001906 cell killing 7/982 188/18722 0.868972799455402 0.926714807188586 CADM1/B2M/HLA-B/HLA-A/HLA-E/CD59/PRDX1 7 GO:1901361 organic cyclic compound catabolic process 21/982 495/18722 0.869842825759296 0.927084344102936 KCNQ1OT1/LIN28B/AXIN2/NUDT4/COMT/GSTZ1/PUM1/REXO4/TET2/QPRT/TARDBP/FEN1/YTHDF2/PUM2/DHX9/METTL3/SLIRP/UPF3A/PDE7A/VIM/DFFA 21 GO:0001825 blastocyst formation 1/982 38/18722 0.87119038270591 0.927084344102936 YAP1 1 GO:0002385 mucosal immune response 1/982 38/18722 0.87119038270591 0.927084344102936 RAB17 1 GO:0006858 extracellular transport 1/982 38/18722 0.87119038270591 0.927084344102936 NPHP3 1 GO:0030279 negative regulation of ossification 1/982 38/18722 0.87119038270591 0.927084344102936 RBPJ 1 GO:0032717 negative regulation of interleukin-8 production 1/982 38/18722 0.87119038270591 0.927084344102936 TMSB4X 1 GO:0051930 regulation of sensory perception of pain 1/982 38/18722 0.87119038270591 0.927084344102936 COMT 1 GO:0098926 postsynaptic signal transduction 1/982 38/18722 0.87119038270591 0.927084344102936 GNA11 1 GO:0099622 cardiac muscle cell membrane repolarization 1/982 38/18722 0.87119038270591 0.927084344102936 GJA5 1 GO:2000279 negative regulation of DNA biosynthetic process 1/982 38/18722 0.87119038270591 0.927084344102936 GJA1 1 GO:0002263 cell activation involved in immune response 11/982 279/18722 0.871274435351341 0.927084344102936 LRP1/APP/TFRC/SWAP70/EIF2AK4/FER/CD46/SNX4/GRN/PDPK1/ANXA3 11 GO:0030217 T cell differentiation 10/982 257/18722 0.87210185052258 0.927744868864957 SOX4/GPR89A/PTPRK/CHD7/B2M/CTSL/CD46/GLI3/METTL3/BAD 10 GO:0033108 mitochondrial respiratory chain complex assembly 3/982 93/18722 0.872250927322421 0.927744868864957 TFAM/SCO1/SURF1 3 GO:1903313 positive regulation of mRNA metabolic process 4/982 118/18722 0.872581936802061 0.927907723212956 PUM1/TARDBP/YTHDF2/METTL3 4 GO:0043967 histone H4 acetylation 2/982 67/18722 0.873050428495812 0.928216680602151 MORF4L2/BRCA2 2 GO:0008380 RNA splicing 18/982 434/18722 0.876849396065286 0.931917268592328 ESRP1/ESRP2/MBNL3/MBNL2/TARDBP/RTCB/AQR/USP39/DHX9/SLC38A2/METTL3/DHX15/PRPF39/ZNF326/MPHOSPH10/SRPK1/DDX1/HNRNPLL 18 GO:0001941 postsynaptic membrane organization 1/982 39/18722 0.877960402197603 0.931917268592328 PTN 1 GO:0032728 positive regulation of interferon-beta production 1/982 39/18722 0.877960402197603 0.931917268592328 DHX9 1 GO:0042417 dopamine metabolic process 1/982 39/18722 0.877960402197603 0.931917268592328 COMT 1 GO:0043267 negative regulation of potassium ion transport 1/982 39/18722 0.877960402197603 0.931917268592328 ANK3 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/982 39/18722 0.877960402197603 0.931917268592328 BHLHE41 1 GO:0051931 regulation of sensory perception 1/982 39/18722 0.877960402197603 0.931917268592328 COMT 1 GO:1901861 regulation of muscle tissue development 1/982 39/18722 0.877960402197603 0.931917268592328 CENPF 1 GO:0010324 membrane invagination 5/982 144/18722 0.87943323615169 0.933100846169084 DOCK1/FNBP1L/RHOBTB1/RAB31/GSN 5 GO:0031644 regulation of nervous system process 5/982 144/18722 0.87943323615169 0.933100846169084 DAG1/APP/TNFRSF21/PARD3/COMT 5 GO:0006304 DNA modification 4/982 120/18722 0.880695200397323 0.933718624011198 PARP2/TET2/TRIM28/DNMT1 4 GO:0072655 establishment of protein localization to mitochondrion 4/982 120/18722 0.880695200397323 0.933718624011198 LMAN1/PINK1/LEPROT/HUWE1 4 GO:0002532 production of molecular mediator involved in inflammatory response 3/982 95/18722 0.881268555599526 0.933718624011198 SNX4/GRN/CHID1 3 GO:0032479 regulation of type I interferon production 3/982 95/18722 0.881268555599526 0.933718624011198 DTX4/ZCCHC3/DHX9 3 GO:0032606 type I interferon production 3/982 95/18722 0.881268555599526 0.933718624011198 DTX4/ZCCHC3/DHX9 3 GO:0042773 ATP synthesis coupled electron transport 3/982 95/18722 0.881268555599526 0.933718624011198 CYC1/PINK1/COX6A1 3 GO:0042775 mitochondrial ATP synthesis coupled electron transport 3/982 95/18722 0.881268555599526 0.933718624011198 CYC1/PINK1/COX6A1 3 GO:0006310 DNA recombination 12/982 305/18722 0.88150253866975 0.933776856559995 TFRC/SWAP70/APEX2/POLQ/MCM2/FEN1/RMI2/MAGEF1/TOP2A/BRCA2/WDR48/RAD50 12 GO:0034605 cellular response to heat 2/982 69/18722 0.883372882854047 0.934542080238438 SLC52A3/ATR 2 GO:0050810 regulation of steroid biosynthetic process 2/982 69/18722 0.883372882854047 0.934542080238438 ADM/INSIG1 2 GO:0051966 regulation of synaptic transmission, glutamatergic 2/982 69/18722 0.883372882854047 0.934542080238438 EGFR/CLN3 2 GO:0051321 meiotic cell cycle 10/982 261/18722 0.883378040914099 0.934542080238438 ASPM/SPIN1/SMC2/P3H4/YTHDF2/TOP2A/BRCA2/METTL3/CCNE1/RAD50 10 GO:0007339 binding of sperm to zona pellucida 1/982 40/18722 0.88437494402932 0.934542080238438 LY6K 1 GO:0009187 cyclic nucleotide metabolic process 1/982 40/18722 0.88437494402932 0.934542080238438 PDE7A 1 GO:0042073 intraciliary transport 1/982 40/18722 0.88437494402932 0.934542080238438 IFT74 1 GO:0045429 positive regulation of nitric oxide biosynthetic process 1/982 40/18722 0.88437494402932 0.934542080238438 ASS1 1 GO:0055081 anion homeostasis 1/982 40/18722 0.88437494402932 0.934542080238438 ATP6V1B1 1 GO:0071276 cellular response to cadmium ion 1/982 40/18722 0.88437494402932 0.934542080238438 EGFR 1 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 1/982 40/18722 0.88437494402932 0.934542080238438 NFAT5 1 GO:2000781 positive regulation of double-strand break repair 1/982 40/18722 0.88437494402932 0.934542080238438 WDR48 1 GO:0034470 ncRNA processing 16/982 395/18722 0.886413832936875 0.936472438333491 LIN28B/CHD7/MAK16/NPM3/TRIT1/REXO4/ERI2/RPF2/RTCB/YTHDF2/METTL3/WDR43/HEATR1/MPHOSPH10/DCAF13/DDX1 16 GO:0045580 regulation of T cell differentiation 5/982 146/18722 0.886560755462189 0.936472438333491 SOX4/CD46/GLI3/METTL3/BAD 5 GO:0050851 antigen receptor-mediated signaling pathway 9/982 240/18722 0.88793407745402 0.937733174326821 PAWR/TNFRSF21/HLA-A/HRAS/SLC39A10/KCNN4/MAP3K7/VAV3/BCL10 9 GO:0031109 microtubule polymerization or depolymerization 4/982 122/18722 0.888356071864574 0.937988921223809 MET/HDAC6/CAMSAP2/TPX2 4 GO:0010596 negative regulation of endothelial cell migration 3/982 97/18722 0.889715146857487 0.93850667709732 NR2F2/PPARG/SERPINF1 3 GO:0002251 organ or tissue specific immune response 1/982 41/18722 0.890452655460816 0.93850667709732 RAB17 1 GO:0032733 positive regulation of interleukin-10 production 1/982 41/18722 0.890452655460816 0.93850667709732 CD46 1 GO:0032735 positive regulation of interleukin-12 production 1/982 41/18722 0.890452655460816 0.93850667709732 ISL1 1 GO:0048634 regulation of muscle organ development 1/982 41/18722 0.890452655460816 0.93850667709732 CENPF 1 GO:0070296 sarcoplasmic reticulum calcium ion transport 1/982 41/18722 0.890452655460816 0.93850667709732 CHD7 1 GO:1901385 regulation of voltage-gated calcium channel activity 1/982 41/18722 0.890452655460816 0.93850667709732 EHD3 1 GO:1904407 positive regulation of nitric oxide metabolic process 1/982 41/18722 0.890452655460816 0.93850667709732 ASS1 1 GO:0002253 activation of immune response 15/982 375/18722 0.890518803516965 0.93850667709732 PAWR/TNFRSF21/CD46/HLA-A/HRAS/SLC39A10/KCNN4/YES1/PTK2/MAP3K7/ZCCHC3/PSPC1/CD59/VAV3/BCL10 15 GO:0006813 potassium ion transport 9/982 241/18722 0.890645715420194 0.93850667709732 GJA5/WNK2/KCNG1/SLC1A3/FXYD3/KCNN4/ITGB1/ANK3/ABCB8 9 GO:0032722 positive regulation of chemokine production 2/982 71/18722 0.892913790693843 0.940706591044049 LRP1/APP 2 GO:0032642 regulation of chemokine production 3/982 98/18722 0.89373340691527 0.941379937493952 LRP1/APP/GSTP1 3 GO:1903311 regulation of mRNA metabolic process 11/982 288/18722 0.894782470499203 0.94189757267954 AXIN2/MBNL3/PUM1/MBNL2/TARDBP/YTHDF2/PUM2/DHX9/METTL3/VIM/SRPK1 11 GO:0022618 ribonucleoprotein complex assembly 8/982 220/18722 0.896079262053453 0.94189757267954 RPF2/USP39/ATR/DHX9/RPL10/PRPF39/SRPK1/DDX1 8 GO:0010677 negative regulation of cellular carbohydrate metabolic process 1/982 42/18722 0.896211206520046 0.94189757267954 NUPR1 1 GO:0014003 oligodendrocyte development 1/982 42/18722 0.896211206520046 0.94189757267954 GSTP1 1 GO:0032467 positive regulation of cytokinesis 1/982 42/18722 0.896211206520046 0.94189757267954 RACGAP1 1 GO:0032691 negative regulation of interleukin-1 beta production 1/982 42/18722 0.896211206520046 0.94189757267954 GSTP1 1 GO:0045292 mRNA cis splicing, via spliceosome 1/982 42/18722 0.896211206520046 0.94189757267954 PRPF39 1 GO:0046688 response to copper ion 1/982 42/18722 0.896211206520046 0.94189757267954 APP 1 GO:0051602 response to electrical stimulus 1/982 42/18722 0.896211206520046 0.94189757267954 CYFIP1 1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 1/982 42/18722 0.896211206520046 0.94189757267954 ERI2 1 GO:1903432 regulation of TORC1 signaling 1/982 42/18722 0.896211206520046 0.94189757267954 RRAGA 1 GO:0003300 cardiac muscle hypertrophy 3/982 99/18722 0.897619753986768 0.94280802190797 PARP2/IL6ST/LMNA 3 GO:0007631 feeding behavior 3/982 99/18722 0.897619753986768 0.94280802190797 APP/EIF2AK4/UBR3 3 GO:0032602 chemokine production 3/982 99/18722 0.897619753986768 0.94280802190797 LRP1/APP/GSTP1 3 GO:0070585 protein localization to mitochondrion 4/982 125/18722 0.89904079330461 0.943765089900825 LMAN1/PINK1/LEPROT/HUWE1 4 GO:0045619 regulation of lymphocyte differentiation 6/982 174/18722 0.899141147493652 0.943765089900825 SOX4/MMP14/CD46/GLI3/METTL3/BAD 6 GO:0044728 DNA methylation or demethylation 3/982 100/18722 0.901377716546766 0.943765089900825 TET2/TRIM28/DNMT1 3 GO:0060079 excitatory postsynaptic potential 3/982 100/18722 0.901377716546766 0.943765089900825 APP/PPP1R9A/SLC29A1 3 GO:0001709 cell fate determination 1/982 43/18722 0.901667341166583 0.943765089900825 ISL1 1 GO:0033173 calcineurin-NFAT signaling cascade 1/982 43/18722 0.901667341166583 0.943765089900825 NFAT5 1 GO:0042088 T-helper 1 type immune response 1/982 43/18722 0.901667341166583 0.943765089900825 HRAS 1 GO:0045840 positive regulation of mitotic nuclear division 1/982 43/18722 0.901667341166583 0.943765089900825 LRP5 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/982 43/18722 0.901667341166583 0.943765089900825 GLI3 1 GO:0098815 modulation of excitatory postsynaptic potential 1/982 43/18722 0.901667341166583 0.943765089900825 APP 1 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/982 43/18722 0.901667341166583 0.943765089900825 IFI6 1 GO:0002637 regulation of immunoglobulin production 2/982 73/18722 0.901724915070041 0.943765089900825 TFRC/HLA-E 2 GO:0009166 nucleotide catabolic process 2/982 73/18722 0.901724915070041 0.943765089900825 NUDT4/PDE7A 2 GO:0042274 ribosomal small subunit biogenesis 2/982 73/18722 0.901724915070041 0.943765089900825 HEATR1/DCAF13 2 GO:0051865 protein autoubiquitination 2/982 73/18722 0.901724915070041 0.943765089900825 MDM2/TRIM37 2 GO:0051937 catecholamine transport 2/982 73/18722 0.901724915070041 0.943765089900825 SYT7/PINK1 2 GO:0002429 immune response-activating cell surface receptor signaling pathway 11/982 291/18722 0.901787808294807 0.943765089900825 PAWR/TNFRSF21/HLA-A/HRAS/SLC39A10/KCNN4/YES1/PTK2/MAP3K7/VAV3/BCL10 11 GO:0002757 immune response-activating signal transduction 11/982 291/18722 0.901787808294807 0.943765089900825 PAWR/TNFRSF21/HLA-A/HRAS/SLC39A10/KCNN4/YES1/PTK2/MAP3K7/VAV3/BCL10 11 GO:0032874 positive regulation of stress-activated MAPK cascade 4/982 126/18722 0.902396706732517 0.9442128831127 APP/SEMA4C/TRAF4/HRAS 4 GO:0007018 microtubule-based movement 15/982 382/18722 0.90500419965502 0.946568318979382 DST/APP/KIF16B/MREG/ARHGAP21/CLN3/HDAC6/KIFC3/ARMCX3/IFT74/NPHP3/SLIRP/FLOT2/KIF4A/DYNC1LI2 15 GO:0048024 regulation of mRNA splicing, via spliceosome 3/982 101/18722 0.905010775834006 0.946568318979382 MBNL3/MBNL2/SRPK1 3 GO:0006911 phagocytosis, engulfment 4/982 127/18722 0.905653672925694 0.947050833596716 DOCK1/RHOBTB1/RAB31/GSN 4 GO:1901568 fatty acid derivative metabolic process 2/982 74/18722 0.905872327599426 0.947089609292165 SLC25A1/HSD17B12 2 GO:0006378 mRNA polyadenylation 1/982 44/18722 0.906836925778951 0.947148859604126 APP 1 GO:0021762 substantia nigra development 1/982 44/18722 0.906836925778951 0.947148859604126 BASP1 1 GO:0032007 negative regulation of TOR signaling 1/982 44/18722 0.906836925778951 0.947148859604126 SH3BP4 1 GO:0043039 tRNA aminoacylation 1/982 44/18722 0.906836925778951 0.947148859604126 GATB 1 GO:0050999 regulation of nitric-oxide synthase activity 1/982 44/18722 0.906836925778951 0.947148859604126 EGFR 1 GO:0014897 striated muscle hypertrophy 3/982 102/18722 0.908522363232884 0.947885180372879 PARP2/IL6ST/LMNA 3 GO:0045833 negative regulation of lipid metabolic process 3/982 102/18722 0.908522363232884 0.947885180372879 ACADVL/PDGFA/INSIG1 3 GO:0062014 negative regulation of small molecule metabolic process 3/982 102/18722 0.908522363232884 0.947885180372879 ACADVL/NUPR1/INSIG1 3 GO:0032612 interleukin-1 production 4/982 128/18722 0.908813992915025 0.947885180372879 APP/ISL1/GSTP1/NLRP2 4 GO:0032652 regulation of interleukin-1 production 4/982 128/18722 0.908813992915025 0.947885180372879 APP/ISL1/GSTP1/NLRP2 4 GO:0035303 regulation of dephosphorylation 4/982 128/18722 0.908813992915025 0.947885180372879 SWAP70/SLC39A10/PINK1/HSP90B1 4 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 4/982 128/18722 0.908813992915025 0.947885180372879 APP/SEMA4C/TRAF4/HRAS 4 GO:0033077 T cell differentiation in thymus 2/982 75/18722 0.909855611170267 0.948781860828491 B2M/GLI3 2 GO:0017157 regulation of exocytosis 7/982 202/18722 0.910326855752839 0.949083525805879 SYT7/FER/TRPV6/SNX4/EXPH5/RAB13/PDPK1 7 GO:0003009 skeletal muscle contraction 1/982 45/18722 0.911734995105702 0.94922349989448 GAA 1 GO:0022602 ovulation cycle process 1/982 45/18722 0.911734995105702 0.94922349989448 ADAMTS1 1 GO:0035305 negative regulation of dephosphorylation 1/982 45/18722 0.911734995105702 0.94922349989448 SWAP70 1 GO:0043038 amino acid activation 1/982 45/18722 0.911734995105702 0.94922349989448 GATB 1 GO:0043631 RNA polyadenylation 1/982 45/18722 0.911734995105702 0.94922349989448 APP 1 GO:0045933 positive regulation of muscle contraction 1/982 45/18722 0.911734995105702 0.94922349989448 CTTN 1 GO:0046189 phenol-containing compound biosynthetic process 1/982 45/18722 0.911734995105702 0.94922349989448 OPN3 1 GO:0071826 ribonucleoprotein complex subunit organization 8/982 227/18722 0.913548750730448 0.950490178297225 RPF2/USP39/ATR/DHX9/RPL10/PRPF39/SRPK1/DDX1 8 GO:0006305 DNA alkylation 2/982 76/18722 0.913680550993536 0.950490178297225 TRIM28/DNMT1 2 GO:0006306 DNA methylation 2/982 76/18722 0.913680550993536 0.950490178297225 TRIM28/DNMT1 2 GO:0032720 negative regulation of tumor necrosis factor production 2/982 76/18722 0.913680550993536 0.950490178297225 GSTP1/TRIM27 2 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 3/982 104/18722 0.915194584944465 0.951685597103336 GNA11/TGM2/P2RY6 3 GO:0046634 regulation of alpha-beta T cell activation 3/982 104/18722 0.915194584944465 0.951685597103336 HLA-A/GLI3/HLA-E 3 GO:0006479 protein methylation 6/982 181/18722 0.917942957720237 0.954163106311031 BRD4/TET2/LMNA/DNMT1/KMT5A/LCMT1 6 GO:0008213 protein alkylation 6/982 181/18722 0.917942957720237 0.954163106311031 BRD4/TET2/LMNA/DNMT1/KMT5A/LCMT1 6 GO:0016079 synaptic vesicle exocytosis 3/982 105/18722 0.918361813166347 0.954408291985588 SYT7/SYNJ1/NAPA 3 GO:0051250 negative regulation of lymphocyte activation 5/982 157/18722 0.919611579556177 0.954544320298143 SOCS6/PAWR/DLG5/TNFRSF21/GLI3 5 GO:1902107 positive regulation of leukocyte differentiation 5/982 157/18722 0.919611579556177 0.954544320298143 SOX4/MMP14/CD46/GLI3/BAD 5 GO:1903708 positive regulation of hemopoiesis 5/982 157/18722 0.919611579556177 0.954544320298143 SOX4/MMP14/CD46/GLI3/BAD 5 GO:0046034 ATP metabolic process 10/982 277/18722 0.920628262326257 0.954544320298143 APP/ATP6V1B1/SLC25A13/TMSB4X/CYC1/PINK1/NUPR1/DHTKD1/COX6A1/BAD 10 GO:0045581 negative regulation of T cell differentiation 1/982 47/18722 0.920772827752808 0.954544320298143 GLI3 1 GO:0047496 vesicle transport along microtubule 1/982 47/18722 0.920772827752808 0.954544320298143 CLN3 1 GO:0051972 regulation of telomerase activity 1/982 47/18722 0.920772827752808 0.954544320298143 PKIB 1 GO:0090279 regulation of calcium ion import 1/982 47/18722 0.920772827752808 0.954544320298143 TRIM27 1 GO:1900744 regulation of p38MAPK cascade 1/982 47/18722 0.920772827752808 0.954544320298143 PHLPP1 1 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 2/982 78/18722 0.920877767512368 0.954544320298143 GNAI1/PSAP 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2/982 78/18722 0.920877767512368 0.954544320298143 NRP1/PLK2 2 GO:1901616 organic hydroxy compound catabolic process 2/982 78/18722 0.920877767512368 0.954544320298143 SYNJ1/COMT 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 2/982 78/18722 0.920877767512368 0.954544320298143 GSTP1/TRIM27 2 GO:0001824 blastocyst development 3/982 106/18722 0.921420753968779 0.954544320298143 ELF3/YAP1/BRCA2 3 GO:0006090 pyruvate metabolic process 3/982 106/18722 0.921420753968779 0.954544320298143 APP/NUPR1/DHTKD1 3 GO:0099565 chemical synaptic transmission, postsynaptic 3/982 106/18722 0.921420753968779 0.954544320298143 APP/PPP1R9A/SLC29A1 3 GO:0006338 chromatin remodeling 9/982 255/18722 0.923211042810957 0.956054190184848 KDM5B/CHD7/MCM2/NPM3/SMARCA2/CENPW/SMARCA1/TOP1/RERE 9 GO:0006997 nucleus organization 4/982 133/18722 0.923244815176587 0.956054190184848 TARDBP/LMNA/NUP153/SRPK1 4 GO:0042149 cellular response to glucose starvation 1/982 48/18722 0.924938883075257 0.956858630329342 SLC2A1 1 GO:0097720 calcineurin-mediated signaling 1/982 48/18722 0.924938883075257 0.956858630329342 NFAT5 1 GO:1902003 regulation of amyloid-beta formation 1/982 48/18722 0.924938883075257 0.956858630329342 EFNA1 1 GO:1905710 positive regulation of membrane permeability 1/982 48/18722 0.924938883075257 0.956858630329342 JAM3 1 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 1/982 48/18722 0.924938883075257 0.956858630329342 USP14 1 GO:0008277 regulation of G protein-coupled receptor signaling pathway 4/982 134/18722 0.925872244498451 0.957634270732485 MET/ADM/CCL5/ZDHHC3 4 GO:0043271 negative regulation of ion transport 5/982 160/18722 0.927006805986148 0.958091716520354 GABRE/WNK2/SLC43A2/ANK3/TRIM27 5 GO:0098659 inorganic cation import across plasma membrane 3/982 108/18722 0.927226323068006 0.958091716520354 WNK2/TRPV6/SLC39A10 3 GO:0099587 inorganic ion import across plasma membrane 3/982 108/18722 0.927226323068006 0.958091716520354 WNK2/TRPV6/SLC39A10 3 GO:0140053 mitochondrial gene expression 3/982 108/18722 0.927226323068006 0.958091716520354 GATB/TRIT1/TFAM 3 GO:0051303 establishment of chromosome localization 2/982 80/18722 0.927507174657485 0.958091716520354 CENPF/SPDL1 2 GO:0006376 mRNA splice site selection 1/982 49/18722 0.928886083290535 0.958091716520354 PRPF39 1 GO:0008206 bile acid metabolic process 1/982 49/18722 0.928886083290535 0.958091716520354 SLC27A2 1 GO:0018198 peptidyl-cysteine modification 1/982 49/18722 0.928886083290535 0.958091716520354 ZDHHC3 1 GO:0032692 negative regulation of interleukin-1 production 1/982 49/18722 0.928886083290535 0.958091716520354 GSTP1 1 GO:0050832 defense response to fungus 1/982 49/18722 0.928886083290535 0.958091716520354 BCL10 1 GO:0072666 establishment of protein localization to vacuole 1/982 49/18722 0.928886083290535 0.958091716520354 SCARB2 1 GO:0086009 membrane repolarization 1/982 49/18722 0.928886083290535 0.958091716520354 GJA5 1 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/982 49/18722 0.928886083290535 0.958091716520354 TIMP3 1 GO:1990573 potassium ion import across plasma membrane 1/982 49/18722 0.928886083290535 0.958091716520354 WNK2 1 GO:0034660 ncRNA metabolic process 19/982 485/18722 0.929073304751122 0.958095365279133 KCNQ1OT1/LIN28B/CHD7/MAK16/NPM3/GATB/HRAS/TRIT1/REXO4/ERI2/RPF2/RTCB/YTHDF2/METTL3/WDR43/HEATR1/MPHOSPH10/DCAF13/DDX1 19 GO:0030098 lymphocyte differentiation 14/982 374/18722 0.930155974575045 0.95902225012521 PBX1/SOX4/GPR89A/PTPRK/MMP14/CHD7/B2M/CTSL/CD46/GLI3/ITGB1/METTL3/BAD/RBPJ 14 GO:0099024 plasma membrane invagination 4/982 136/18722 0.930885478592143 0.959492753549729 DOCK1/RHOBTB1/RAB31/GSN 4 GO:0007080 mitotic metaphase plate congression 1/982 50/18722 0.932625914394733 0.959492753549729 SPDL1 1 GO:0007140 male meiotic nuclear division 1/982 50/18722 0.932625914394733 0.959492753549729 BRCA2 1 GO:0008089 anterograde axonal transport 1/982 50/18722 0.932625914394733 0.959492753549729 KIF4A 1 GO:0038202 TORC1 signaling 1/982 50/18722 0.932625914394733 0.959492753549729 RRAGA 1 GO:0043628 ncRNA 3'-end processing 1/982 50/18722 0.932625914394733 0.959492753549729 ERI2 1 GO:0046638 positive regulation of alpha-beta T cell differentiation 1/982 50/18722 0.932625914394733 0.959492753549729 GLI3 1 GO:0099054 presynapse assembly 1/982 50/18722 0.932625914394733 0.959492753549729 APP 1 GO:1902930 regulation of alcohol biosynthetic process 1/982 50/18722 0.932625914394733 0.959492753549729 P2RY6 1 GO:0006939 smooth muscle contraction 3/982 110/18722 0.932635786138253 0.959492753549729 CTTN/ATP2B1/TBX3 3 GO:0009408 response to heat 3/982 110/18722 0.932635786138253 0.959492753549729 SLC52A3/DNAJB4/ATR 3 GO:0050684 regulation of mRNA processing 4/982 137/18722 0.933275423187616 0.959961468614988 MBNL3/MBNL2/DHX9/SRPK1 4 GO:0002312 B cell activation involved in immune response 2/982 82/18722 0.933609530818808 0.96011579510073 TFRC/SWAP70 2 GO:0006805 xenobiotic metabolic process 3/982 111/18722 0.935199363268728 0.961421315411791 CYP2J2/GSTP1/GSTA4 3 GO:0007224 smoothened signaling pathway 4/982 138/18722 0.935590292089865 0.961421315411791 FGFR2/DLG5/GLI3/TCTN3 4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/982 51/18722 0.936169260156535 0.961421315411791 PINK1 1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 1/982 51/18722 0.936169260156535 0.961421315411791 GSTP1 1 GO:0050982 detection of mechanical stimulus 1/982 51/18722 0.936169260156535 0.961421315411791 PTK2 1 GO:0051339 regulation of lyase activity 1/982 51/18722 0.936169260156535 0.961421315411791 NF1 1 GO:0060632 regulation of microtubule-based movement 1/982 51/18722 0.936169260156535 0.961421315411791 HDAC6 1 GO:1901292 nucleoside phosphate catabolic process 2/982 83/18722 0.936475146067009 0.961546134229433 NUDT4/PDE7A 2 GO:0007286 spermatid development 5/982 165/18722 0.937994833179456 0.962916955296997 JAM3/HOOK1/SMARCA2/SLIRP/SRPK1 5 GO:0001818 negative regulation of cytokine production 13/982 357/18722 0.938796889163024 0.96355068356441 LGR4/CD200/TNFRSF21/TMSB4X/TSKU/ATP2B1/RNF128/CD24/GSTP1/CD2AP/CHID1/RPS6KA4/TRIM27 13 GO:0010921 regulation of phosphatase activity 2/982 84/18722 0.939223202314428 0.963798588092083 SLC39A10/HSP90B1 2 GO:0071347 cellular response to interleukin-1 3/982 113/18722 0.940058432931144 0.964465929616217 MAP3K7/CCL5/RPS6KA4 3 GO:0097006 regulation of plasma lipoprotein particle levels 2/982 85/18722 0.941858131915581 0.965994745402969 LDLR/ANXA2 2 GO:0006119 oxidative phosphorylation 4/982 141/18722 0.94210415449864 0.965994745402969 CYC1/PINK1/NUPR1/COX6A1 4 GO:0030183 B cell differentiation 4/982 141/18722 0.94210415449864 0.965994745402969 MMP14/ITGB1/BAD/RBPJ 4 GO:0031279 regulation of cyclase activity 1/982 53/18722 0.942707207210439 0.966233207468983 NF1 1 GO:0099172 presynapse organization 1/982 53/18722 0.942707207210439 0.966233207468983 APP 1 GO:0071805 potassium ion transmembrane transport 7/982 219/18722 0.945031611161508 0.968425320985938 WNK2/KCNG1/SLC1A3/KCNN4/ITGB1/ANK3/ABCB8 7 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/982 54/18722 0.945720840641226 0.968941250203228 CD46 1 GO:0006325 chromatin organization 15/982 409/18722 0.946899795905319 0.969958628327208 KDM5B/CHD7/BRD4/SPIN1/MCM2/NPM3/SMARCA2/CBX4/CENPW/SMARCA1/TRIM28/TOP1/DNMT1/RERE/SRPK1 15 GO:0038066 p38MAPK cascade 1/982 55/18722 0.948576108184097 0.9709130652057 PHLPP1 1 GO:0045620 negative regulation of lymphocyte differentiation 1/982 55/18722 0.948576108184097 0.9709130652057 GLI3 1 GO:0046164 alcohol catabolic process 1/982 55/18722 0.948576108184097 0.9709130652057 SYNJ1 1 GO:0048016 inositol phosphate-mediated signaling 1/982 55/18722 0.948576108184097 0.9709130652057 NFAT5 1 GO:0070098 chemokine-mediated signaling pathway 2/982 88/18722 0.949126385602431 0.971285702825638 CCL5/FOXC1 2 GO:0007269 neurotransmitter secretion 4/982 145/18722 0.949854922555055 0.9716499854966 SYT7/PPP1R9A/SYNJ1/NAPA 4 GO:0099643 signal release from synapse 4/982 145/18722 0.949854922555055 0.9716499854966 SYT7/PPP1R9A/SYNJ1/NAPA 4 GO:0048515 spermatid differentiation 5/982 172/18722 0.950884060866897 0.972155835709414 JAM3/HOOK1/SMARCA2/SLIRP/SRPK1 5 GO:0002090 regulation of receptor internalization 1/982 56/18722 0.951281323899703 0.972155835709414 AHI1 1 GO:0032608 interferon-beta production 1/982 56/18722 0.951281323899703 0.972155835709414 DHX9 1 GO:0032648 regulation of interferon-beta production 1/982 56/18722 0.951281323899703 0.972155835709414 DHX9 1 GO:0070534 protein K63-linked ubiquitination 1/982 56/18722 0.951281323899703 0.972155835709414 TRIM27 1 GO:0006323 DNA packaging 6/982 199/18722 0.952913579120096 0.973633149596556 MCM2/SMC2/TOP2A/CENPW/KMT5A/SRPK1 6 GO:0034205 amyloid-beta formation 1/982 57/18722 0.953844365790332 0.973821141507609 EFNA1 1 GO:0050879 multicellular organismal movement 1/982 57/18722 0.953844365790332 0.973821141507609 GAA 1 GO:0050881 musculoskeletal movement 1/982 57/18722 0.953844365790332 0.973821141507609 GAA 1 GO:0051785 positive regulation of nuclear division 1/982 57/18722 0.953844365790332 0.973821141507609 LRP5 1 GO:0002181 cytoplasmic translation 4/982 148/18722 0.955030095470368 0.974749450057391 YTHDF2/DHX9/METTL3/RPL10 4 GO:0002366 leukocyte activation involved in immune response 9/982 275/18722 0.955127384824257 0.974749450057391 TFRC/SWAP70/EIF2AK4/FER/CD46/SNX4/GRN/PDPK1/ANXA3 9 GO:0002443 leukocyte mediated immunity 16/982 440/18722 0.955778585894993 0.97522322066281 CADM1/TFRC/SWAP70/FER/B2M/CD46/HLA-B/HLA-A/SNX4/MAP3K7/HLA-E/PRDX1/PDPK1/DDX1/ANXA3/BCL10 16 GO:0000375 RNA splicing, via transesterification reactions 11/982 324/18722 0.956296041930308 0.975560366655288 ESRP2/MBNL3/MBNL2/AQR/USP39/DHX9/METTL3/PRPF39/MPHOSPH10/SRPK1/DDX1 11 GO:0006406 mRNA export from nucleus 1/982 59/18722 0.958573395708271 0.977119177645953 ENY2 1 GO:0032768 regulation of monooxygenase activity 1/982 59/18722 0.958573395708271 0.977119177645953 EGFR 1 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 1/982 59/18722 0.958573395708271 0.977119177645953 ENY2 1 GO:2001258 negative regulation of cation channel activity 1/982 59/18722 0.958573395708271 0.977119177645953 ANK3 1 GO:1901019 regulation of calcium ion transmembrane transporter activity 2/982 93/18722 0.959351614448392 0.977721379633218 P2RY6/EHD3 2 GO:0009620 response to fungus 1/982 60/18722 0.960753159166154 0.978958483729373 BCL10 1 GO:0045666 positive regulation of neuron differentiation 2/982 95/18722 0.962863281969397 0.980916968506323 BMP7/ETV5 2 GO:0016064 immunoglobulin mediated immune response 6/982 207/18722 0.963599745919898 0.981475546713179 TFRC/SWAP70/B2M/CD46/HLA-E/BCL10 6 GO:0002440 production of molecular mediator of immune response 10/982 308/18722 0.964718026419518 0.981714038773138 TFRC/SWAP70/POLQ/B2M/HLA-A/TRIM6/MAP3K7/HLA-E/DDX1/BCL10 10 GO:0032757 positive regulation of interleukin-8 production 1/982 62/18722 0.964774954515166 0.981714038773138 BCL10 1 GO:0045428 regulation of nitric oxide biosynthetic process 1/982 62/18722 0.964774954515166 0.981714038773138 ASS1 1 GO:0048488 synaptic vesicle endocytosis 1/982 62/18722 0.964774954515166 0.981714038773138 SYNJ1 1 GO:0140238 presynaptic endocytosis 1/982 62/18722 0.964774954515166 0.981714038773138 SYNJ1 1 GO:0008033 tRNA processing 3/982 127/18722 0.965680384061143 0.982278125866642 TRIT1/RTCB/DDX1 3 GO:0071222 cellular response to lipopolysaccharide 6/982 209/18722 0.965900565971786 0.982278125866642 PPARD/CCL5/GSTP1/VIM/ASS1/BCL10 6 GO:1990868 response to chemokine 2/982 97/18722 0.966082589282184 0.982278125866642 CCL5/FOXC1 2 GO:1990869 cellular response to chemokine 2/982 97/18722 0.966082589282184 0.982278125866642 CCL5/FOXC1 2 GO:0042113 B cell activation 11/982 334/18722 0.966397255288068 0.982337386226915 TFRC/PAWR/SWAP70/MMP14/TNFRSF21/SLC39A10/ITGB1/VAV3/IRS2/BAD/RBPJ 11 GO:0046631 alpha-beta T cell activation 4/982 156/18722 0.96651753568185 0.982337386226915 CTSL/HLA-A/GLI3/HLA-E 4 GO:0090305 nucleic acid phosphodiester bond hydrolysis 8/982 261/18722 0.966972777976403 0.982445271812206 APEX2/REXO4/ERI2/FEN1/N4BP2/RAD50/DFFA/DDX1 8 GO:0019724 B cell mediated immunity 6/982 210/18722 0.967000388321293 0.982445271812206 TFRC/SWAP70/B2M/CD46/HLA-E/BCL10 6 GO:0048247 lymphocyte chemotaxis 1/982 64/18722 0.968384995355844 0.983468873788178 CCL5 1 GO:0080164 regulation of nitric oxide metabolic process 1/982 64/18722 0.968384995355844 0.983468873788178 ASS1 1 GO:0061512 protein localization to cilium 1/982 65/18722 0.970048942968694 0.984775260125479 ZDHHC3 1 GO:0070936 protein K48-linked ubiquitination 1/982 65/18722 0.970048942968694 0.984775260125479 SKP2 1 GO:0051588 regulation of neurotransmitter transport 2/982 100/18722 0.970413257411042 0.984953405459427 PPP1R9A/ITGB1 2 GO:0006303 double-strand break repair via nonhomologous end joining 1/982 66/18722 0.971625398883619 0.985527368184578 POLQ 1 GO:0032715 negative regulation of interleukin-6 production 1/982 66/18722 0.971625398883619 0.985527368184578 CD200 1 GO:2000272 negative regulation of signaling receptor activity 1/982 66/18722 0.971625398883619 0.985527368184578 PPARG 1 GO:0050830 defense response to Gram-positive bacterium 2/982 101/18722 0.971734519665124 0.985527368184578 HLA-A/HLA-E 2 GO:0032677 regulation of interleukin-8 production 2/982 102/18722 0.972998762793769 0.986356099952955 TMSB4X/BCL10 2 GO:1904063 negative regulation of cation transmembrane transport 2/982 102/18722 0.972998762793769 0.986356099952955 SLC43A2/ANK3 2 GO:1902117 positive regulation of organelle assembly 1/982 67/18722 0.973118959041009 0.986356099952955 CEP135 1 GO:0032637 interleukin-8 production 2/982 103/18722 0.97420832526599 0.986864465717601 TMSB4X/BCL10 2 GO:0045639 positive regulation of myeloid cell differentiation 2/982 103/18722 0.97420832526599 0.986864465717601 SCIN/RCOR1 2 GO:0046637 regulation of alpha-beta T cell differentiation 1/982 68/18722 0.974533978189856 0.986864465717601 GLI3 1 GO:0051926 negative regulation of calcium ion transport 1/982 68/18722 0.974533978189856 0.986864465717601 TRIM27 1 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 10/982 320/18722 0.974755699267078 0.986864465717601 ESRP2/MBNL3/MBNL2/AQR/USP39/DHX9/METTL3/PRPF39/SRPK1/DDX1 10 GO:0000398 mRNA splicing, via spliceosome 10/982 320/18722 0.974755699267078 0.986864465717601 ESRP2/MBNL3/MBNL2/AQR/USP39/DHX9/METTL3/PRPF39/SRPK1/DDX1 10 GO:0071216 cellular response to biotic stimulus 7/982 246/18722 0.976133412091231 0.988067509696849 WFS1/PPARD/CCL5/GSTP1/VIM/ASS1/BCL10 7 GO:0071219 cellular response to molecule of bacterial origin 6/982 221/18722 0.977125643489408 0.988879968265571 PPARD/CCL5/GSTP1/VIM/ASS1/BCL10 6 GO:0002449 lymphocyte mediated immunity 11/982 350/18722 0.978271309677526 0.989847362032585 CADM1/TFRC/SWAP70/B2M/CD46/HLA-B/HLA-A/MAP3K7/HLA-E/PRDX1/BCL10 11 GO:0002534 cytokine production involved in inflammatory response 1/982 72/18722 0.979487987846725 0.990694074967717 CHID1 1 GO:1900015 regulation of cytokine production involved in inflammatory response 1/982 72/18722 0.979487987846725 0.990694074967717 CHID1 1 GO:0034766 negative regulation of ion transmembrane transport 2/982 109/18722 0.980437605578516 0.991401986279146 SLC43A2/ANK3 2 GO:0050848 regulation of calcium-mediated signaling 1/982 73/18722 0.980568030524179 0.991401986279146 NFAT5 1 GO:0099003 vesicle-mediated transport in synapse 5/982 200/18722 0.98156802568883 0.992220701936615 SYT7/CYFIP1/NSG1/SYNJ1/NAPA 5 GO:0065004 protein-DNA complex assembly 5/982 201/18722 0.982224792655356 0.992533808523465 CENPF/MCM2/CENPW/CAND1/TAF11 5 GO:0034763 negative regulation of transmembrane transport 3/982 143/18722 0.982258343481236 0.992533808523465 SLC43A2/ANK3/IRS2 3 GO:0002292 T cell differentiation involved in immune response 1/982 75/18722 0.982560659982193 0.99264698866301 CD46 1 GO:0019722 calcium-mediated signaling 5/982 202/18722 0.982859546469399 0.992684229949506 EGFR/PPP1R9A/NFAT5/NUDT4/PDPK1 5 GO:0046632 alpha-beta T cell differentiation 2/982 112/18722 0.982978153314647 0.992684229949506 CTSL/GLI3 2 GO:0006809 nitric oxide biosynthetic process 1/982 76/18722 0.983479061435375 0.992805648238226 ASS1 1 GO:0032543 mitochondrial translation 1/982 76/18722 0.983479061435375 0.992805648238226 GATB 1 GO:0002286 T cell activation involved in immune response 2/982 114/18722 0.984490625452645 0.993634501230843 EIF2AK4/CD46 2 GO:0019932 second-messenger-mediated signaling 9/982 312/18722 0.984786319139528 0.993740654020464 EGFR/PPP1R9A/GNAI1/ADM/NFAT5/NUDT4/ADGRG6/PDE7A/PDPK1 9 GO:0043537 negative regulation of blood vessel endothelial cell migration 1/982 78/18722 0.985173447708664 0.993939014167967 PPARG 1 GO:0035725 sodium ion transmembrane transport 4/982 178/18722 0.985565095679172 0.994141856326157 SLC6A4/WNK2/FXYD3/ANK3 4 GO:0006399 tRNA metabolic process 4/982 179/18722 0.986119918801132 0.9945091833849 GATB/TRIT1/RTCB/DDX1 4 GO:0099504 synaptic vesicle cycle 4/982 181/18722 0.987169345140006 0.995375082978982 SYT7/CYFIP1/SYNJ1/NAPA 4 GO:0046209 nitric oxide metabolic process 1/982 81/18722 0.987395122006797 0.99541031240577 ASS1 1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 1/982 82/18722 0.988059141651094 0.995694838263544 FEN1 1 GO:2001057 reactive nitrogen species metabolic process 1/982 82/18722 0.988059141651094 0.995694838263544 ASS1 1 GO:0001510 RNA methylation 1/982 83/18722 0.988688214767973 0.99575163703992 METTL3 1 GO:0031397 negative regulation of protein ubiquitination 1/982 83/18722 0.988688214767973 0.99575163703992 SOX4 1 GO:0043367 CD4-positive, alpha-beta T cell differentiation 1/982 83/18722 0.988688214767973 0.99575163703992 CTSL 1 GO:0009953 dorsal/ventral pattern formation 1/982 84/18722 0.989284178773437 0.996019273210772 GLI3 1 GO:0019730 antimicrobial humoral response 2/982 122/18722 0.989335861676574 0.996019273210772 HLA-A/HLA-E 2 GO:0002377 immunoglobulin production 5/982 216/18722 0.989781500860168 0.99627562880869 TFRC/SWAP70/POLQ/B2M/HLA-E 5 GO:0017148 negative regulation of translation 6/982 245/18722 0.990062780264129 0.996304942485708 IGF2BP3/EIF2AK4/PUM1/TARDBP/YTHDF2/METTL3 6 GO:0032413 negative regulation of ion transmembrane transporter activity 1/982 86/18722 0.990383651608205 0.996304942485708 ANK3 1 GO:0046928 regulation of neurotransmitter secretion 1/982 86/18722 0.990383651608205 0.996304942485708 PPP1R9A 1 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 10/982 356/18722 0.991306215373996 0.997040728767983 TFRC/SWAP70/B2M/CD46/HLA-B/HLA-A/HRAS/MAP3K7/HLA-E/BCL10 10 GO:0006400 tRNA modification 1/982 90/18722 0.992256022325598 0.997520991811696 TRIT1 1 GO:0006334 nucleosome assembly 2/982 129/18722 0.992337800600354 0.997520991811696 MCM2/CENPW 2 GO:0002285 lymphocyte activation involved in immune response 4/982 194/18722 0.992357443732916 0.997520991811696 TFRC/SWAP70/EIF2AK4/CD46 4 GO:0006956 complement activation 2/982 130/18722 0.992692726713072 0.997665753860382 CD46/CD59 2 GO:0050853 B cell receptor signaling pathway 2/982 131/18722 0.993031550709486 0.997809573251187 SLC39A10/VAV3 2 GO:0032259 methylation 10/982 364/18722 0.993218424908006 0.997809573251187 BRD4/COMT/COQ5/TET2/LMNA/METTL3/TRIM28/DNMT1/KMT5A/LCMT1 10 GO:0009451 RNA modification 3/982 167/18722 0.99364091200041 0.998041786442161 RBM47/TRIT1/METTL3 3 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 1/982 95/18722 0.994092859609432 0.998303495518444 SOX4 1 GO:0043414 macromolecule methylation 8/982 316/18722 0.994291727842432 0.998309482431874 BRD4/TET2/LMNA/METTL3/TRIM28/DNMT1/KMT5A/LCMT1 8 GO:0006959 humoral immune response 8/982 317/18722 0.994481608649543 0.998309482431874 TNFRSF21/CD46/HLA-A/TFEB/HLA-E/YTHDF2/CD59/RBPJ 8 GO:0006910 phagocytosis, recognition 1/982 100/18722 0.995494343746931 0.999133826627668 COLEC12 1 GO:0035710 CD4-positive, alpha-beta T cell activation 1/982 102/18722 0.995957022969867 0.999336176539903 CTSL 1 GO:0071824 protein-DNA complex subunit organization 5/982 241/18722 0.996079137620965 0.999336176539903 CENPF/MCM2/CENPW/CAND1/TAF11 5 GO:0034249 negative regulation of cellular amide metabolic process 6/982 273/18722 0.996430894415398 0.999370996721101 IGF2BP3/EIF2AK4/PUM1/TARDBP/YTHDF2/METTL3 6 GO:0006958 complement activation, classical pathway 1/982 108/18722 0.997079213846463 0.999370996721101 CD46 1 GO:0032410 negative regulation of transporter activity 1/982 109/18722 0.997233302811907 0.999370996721101 ANK3 1 GO:0031497 chromatin assembly 2/982 151/18722 0.997328888109032 0.999370996721101 MCM2/CENPW 2 GO:0030317 flagellated sperm motility 1/982 110/18722 0.997379270503236 0.999370996721101 SLIRP 1 GO:0097722 sperm motility 1/982 110/18722 0.997379270503236 0.999370996721101 SLIRP 1 GO:0090501 RNA phosphodiester bond hydrolysis 2/982 152/18722 0.997455024718184 0.999370996721101 ERI2/FEN1 2 GO:0000956 nuclear-transcribed mRNA catabolic process 1/982 112/18722 0.997648530046186 0.999372908146899 UPF3A 1 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/982 121/18722 0.998556547033946 0.999617805704035 CD46 1 GO:0034728 nucleosome organization 2/982 167/18722 0.998773435180039 0.999617805704035 MCM2/CENPW 2 GO:0060294 cilium movement involved in cell motility 1/982 125/18722 0.998838084140404 0.999617805704035 SLIRP 1 GO:0003341 cilium movement 2/982 175/18722 0.999171469368247 0.999617805704035 NPHP3/SLIRP 2 GO:0006333 chromatin assembly or disassembly 2/982 177/18722 0.99924910186602 0.999617805704035 MCM2/CENPW 2 GO:0042742 defense response to bacterium 7/982 350/18722 0.999408705531324 0.999617805704035 COLEC12/HLA-A/HLA-E/CYBA/GRN/ANXA3/RBPJ 7 GO:0001539 cilium or flagellum-dependent cell motility 1/982 138/18722 0.99942616118607 0.999617805704035 SLIRP 1 GO:0060285 cilium-dependent cell motility 1/982 138/18722 0.99942616118607 0.999617805704035 SLIRP 1 GO:0007608 sensory perception of smell 2/982 456/18722 0.999999999578682 0.999999999578682 UBR3/NAV2 2