ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0005178	integrin binding	13/275	144/18367	2.62824278379971e-07	0.000145867474500884	FBN1/LAMA5/JAM3/ITGA3/PLPP3/DST/ITGB4/ITGB8/ADAM15/TSPAN4/ITGAV/PTK2/ADAM9	13
GO:0005520	insulin-like growth factor binding	5/275	29/18367	6.41861036037353e-05	0.0178116437500366	LRP2/CRIM1/ITGB4/HTRA4/ITGAV	5
GO:0019838	growth factor binding	9/275	141/18367	0.000277610504704647	0.0403434763902951	LRP2/CRIM1/ITGB4/NRP2/LTBP1/LIFR/HTRA4/BMPR2/ITGAV	9
GO:0072349	modified amino acid transmembrane transporter activity	4/275	22/18367	0.000290763793803929	0.0403434763902951	GJA1/SLC16A12/SLC19A2/SLC19A1	4
GO:0043425	bHLH transcription factor binding	4/275	27/18367	0.000657741336537759	0.0611263340885294	ISL1/BHLHE41/TWIST1/SP1	4
GO:0017154	semaphorin receptor activity	3/275	12/18367	0.000660825233389507	0.0611263340885294	MET/NRP2/PLXND1	3
GO:0031994	insulin-like growth factor I binding	3/275	13/18367	0.000849590916967619	0.0673604227024326	LRP2/ITGB4/ITGAV	3
GO:0019199	transmembrane receptor protein kinase activity	8/275	143/18367	0.00142224036568191	0.0986679253691826	MET/DDR1/WEE1/CRIM1/NRP2/LTBP1/BMPR2/PTK2	8
GO:0042887	amide transmembrane transporter activity	4/275	35/18367	0.00178661803104269	0.107250836134903	GJA1/SLC19A2/SLC19A1/SLC38A5	4
GO:0008484	sulfuric ester hydrolase activity	3/275	17/18367	0.00193244749792618	0.107250836134903	ARSD/GALNS/GNS	3
GO:0051539	4 iron, 4 sulfur cluster binding	4/275	42/18367	0.00351933476738573	0.177566435990826	MOCS1/DDX11/EXO5/TYW1	4
GO:0005537	mannose binding	3/275	22/18367	0.00414136595686894	0.181479170768106	MANBA/LMAN2L/CLN5	3
GO:0005201	extracellular matrix structural constituent	8/275	172/18367	0.00445714948672108	0.181479170768106	FBN1/COL14A1/LAMA5/COL4A2/FRAS1/COL21A1/LTBP1/FBN2	8
GO:0051020	GTPase binding	11/275	291/18367	0.00457785295631259	0.181479170768106	MYO5B/PPP1R9A/PAK3/STRIP1/EVI5/FMNL2/XPOT/KNTC1/ABCA1/LZTR1/DNM1L	11
GO:0031267	small GTPase binding	10/275	259/18367	0.00582356102967341	0.215471758097916	MYO5B/PAK3/STRIP1/EVI5/FMNL2/XPOT/KNTC1/ABCA1/LZTR1/DNM1L	10
GO:1901682	sulfur compound transmembrane transporter activity	4/275	52/18367	0.00757749871276554	0.249464061054545	GJA1/SLC13A4/SLC26A2/SLC19A2	4
GO:0001968	fibronectin binding	3/275	28/18367	0.00824736540385551	0.249464061054545	CCDC80/ITGA3/ITGAV	3
GO:0043236	laminin binding	3/275	28/18367	0.00824736540385551	0.249464061054545	BCAM/ITGA3/ADAM9	3
GO:0015301	anion:anion antiporter activity	3/275	29/18367	0.00909866018912606	0.249464061054545	SLC4A2/SLC26A2/SLC19A1	3
GO:0050840	extracellular matrix binding	4/275	56/18367	0.00981465595564384	0.249464061054545	BCAM/ITGA3/ITGAV/ADAM9	4
GO:0005096	GTPase activator activity	14/275	462/18367	0.0101213805858778	0.249464061054545	PLEKHG4B/PLEKHG1/RGL1/ARHGAP23/RALGPS1/EVI5/ARHGAP28/SRGAP3/RASGEF1B/RP2/ARHGEF12/ARHGAP24/CHN2/DNM1L	14
GO:0090482	vitamin transmembrane transporter activity	3/275	31/18367	0.0109502690772302	0.249464061054545	SLC19A2/SLC19A1/SLC52A1	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	6/275	124/18367	0.010962204807568	0.249464061054545	MET/DDR1/WEE1/CRIM1/NRP2/PTK2	6
GO:0097493	structural molecule activity conferring elasticity	2/275	11/18367	0.0112371198673218	0.249464061054545	FBN1/FBN2	2
GO:1901474	azole transmembrane transporter activity	2/275	11/18367	0.0112371198673218	0.249464061054545	SLC19A2/SLC38A5	2
GO:0140323	solute:anion antiporter activity	3/275	33/18367	0.0130038059700071	0.269636330093148	SLC4A2/SLC26A2/SLC19A1	3
GO:0005024	transforming growth factor beta-activated receptor activity	2/275	12/18367	0.0133523787941083	0.269636330093148	LTBP1/BMPR2	2
GO:0017124	SH3 domain binding	6/275	130/18367	0.0136032743110056	0.269636330093148	GJA1/PAK3/BCAR1/LRP2/ADAM15/ADAM9	6
GO:0008271	secondary active sulfate transmembrane transporter activity	2/275	13/18367	0.0156256129535884	0.271643070130521	SLC13A4/SLC26A2	2
GO:0060590	ATPase regulator activity	2/275	13/18367	0.0156256129535884	0.271643070130521	KATNB1/HSPBP1	2
GO:0030695	GTPase regulator activity	14/275	488/18367	0.0156623031426607	0.271643070130521	PLEKHG4B/PLEKHG1/RGL1/ARHGAP23/RALGPS1/EVI5/ARHGAP28/SRGAP3/RASGEF1B/RP2/ARHGEF12/ARHGAP24/CHN2/DNM1L	14
GO:0060589	nucleoside-triphosphatase regulator activity	14/275	488/18367	0.0156623031426607	0.271643070130521	PLEKHG4B/PLEKHG1/RGL1/ARHGAP23/RALGPS1/EVI5/ARHGAP28/SRGAP3/RASGEF1B/RP2/ARHGEF12/ARHGAP24/CHN2/DNM1L	14
GO:0004713	protein tyrosine kinase activity	6/275	136/18367	0.0166598661950263	0.280188658734533	MET/DDR1/WEE1/CRIM1/NRP2/PTK2	6
GO:0004065	arylsulfatase activity	2/275	14/18367	0.0180516531850016	0.284221070882843	ARSD/GALNS	2
GO:0019955	cytokine binding	6/275	139/18367	0.0183528455964685	0.284221070882843	CXCR2/NRP2/LTBP1/LIFR/BMPR2/ITGAV	6
GO:0051536	iron-sulfur cluster binding	4/275	68/18367	0.0189480713921895	0.284221070882843	MOCS1/DDX11/EXO5/TYW1	4
GO:0051540	metal cluster binding	4/275	68/18367	0.0189480713921895	0.284221070882843	MOCS1/DDX11/EXO5/TYW1	4
GO:0005518	collagen binding	4/275	69/18367	0.019884194563312	0.289427941032291	COL14A1/DDR1/ITGA3/ADAM9	4
GO:0008509	anion transmembrane transporter activity	10/275	314/18367	0.0203381796401069	0.289427941032291	GJA1/SLC16A12/GABRE/SLC4A2/SLC13A4/SLC26A2/SLC19A2/SLC19A1/SLC38A5/SLC52A1	10
GO:0008514	organic anion transmembrane transporter activity	7/275	185/18367	0.0216331422875587	0.294428317707734	GJA1/SLC16A12/SLC26A2/SLC19A2/SLC19A1/SLC38A5/SLC52A1	7
GO:0048029	monosaccharide binding	4/275	71/18367	0.021840806137016	0.294428317707734	P3H2/MANBA/LMAN2L/CLN5	4
GO:0030276	clathrin binding	4/275	72/18367	0.0228616733586728	0.294428317707734	SYT1/EPN2/SYT8/DNM1L	4
GO:0030020	extracellular matrix structural constituent conferring tensile strength	3/275	41/18367	0.0232866660455106	0.294428317707734	COL14A1/COL4A2/COL21A1	3
GO:1990380	Lys48-specific deubiquitinase activity	2/275	16/18367	0.0233420648272798	0.294428317707734	USP27X/USP19	2
GO:0008525	phosphatidylcholine transporter activity	2/275	17/18367	0.0261966804711936	0.316068644815488	ATP8B1/ABCA1	2
GO:0015116	sulfate transmembrane transporter activity	2/275	17/18367	0.0261966804711936	0.316068644815488	SLC13A4/SLC26A2	2
GO:0004708	MAP kinase kinase activity	2/275	18/18367	0.0291845860533309	0.330560107338748	PAK3/MAP3K9	2
GO:0046624	sphingolipid transporter activity	2/275	18/18367	0.0291845860533309	0.330560107338748	PLEKHA8/ABCA1	2
GO:1904047	S-adenosyl-L-methionine binding	2/275	18/18367	0.0291845860533309	0.330560107338748	N6AMT1/SETD6	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/275	19/18367	0.0323011811665407	0.358543110948601	LTBP1/BMPR2	2
GO:0003779	actin binding	12/275	440/18367	0.0338846496470287	0.368744716747077	MYO5B/COBL/PPP1R9A/TNNT3/GAS7/PRICKLE4/ACTR3C/TMEM201/PARVA/DST/FMNL2/PTK2	12
GO:0120013	lipid transfer activity	3/275	48/18367	0.0350251655387783	0.373826286038884	STARD4/PLEKHA8/ABCA1	3
GO:0019001	guanyl nucleotide binding	11/275	398/18367	0.0379943545601128	0.390497532978937	EHD3/PDE10A/MOCS1/RAB9B/IRGQ/RP2/IFT22/RAB15/SLC19A1/RAB23/DNM1L	11
GO:0032561	guanyl ribonucleotide binding	11/275	398/18367	0.0379943545601128	0.390497532978937	EHD3/PDE10A/MOCS1/RAB9B/IRGQ/RP2/IFT22/RAB15/SLC19A1/RAB23/DNM1L	11
GO:0015485	cholesterol binding	3/275	50/18367	0.0388437246579973	0.391968494276154	NR1H3/STARD4/ABCA1	3
GO:0120020	cholesterol transfer activity	2/275	22/18367	0.0423786917222941	0.417369829415887	STARD4/ABCA1	2
GO:0016830	carbon-carbon lyase activity	3/275	52/18367	0.0428650095075776	0.417369829415887	PISD/MOCS1/TYW1	3
GO:0005158	insulin receptor binding	2/275	23/18367	0.0459661488014659	0.42518687641356	IRS1/PDPK1	2
GO:0050750	low-density lipoprotein particle receptor binding	2/275	23/18367	0.0459661488014659	0.42518687641356	SYT1/CLU	2
GO:0120015	sterol transfer activity	2/275	23/18367	0.0459661488014659	0.42518687641356	STARD4/ABCA1	2
GO:0005080	protein kinase C binding	3/275	55/18367	0.0492708306933707	0.444544758323178	IRS1/ITGAV/ADAM9	3
GO:0050431	transforming growth factor beta binding	2/275	24/18367	0.0496608558847515	0.444544758323178	LTBP1/ITGAV	2
GO:0035035	histone acetyltransferase binding	2/275	25/18367	0.053458823046444	0.46642443335356	GLI3/SP1	2
GO:0005548	phospholipid transporter activity	3/275	57/18367	0.0537858806029331	0.46642443335356	ATP8B1/PLEKHA8/ABCA1	3
GO:0032934	sterol binding	3/275	60/18367	0.0609160078380956	0.51588973279605	NR1H3/STARD4/ABCA1	3
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/275	27/18367	0.0613490493054762	0.51588973279605	ATP8B1/ABCA1	2
GO:0045296	cadherin binding	9/275	332/18367	0.0629870485300636	0.521758387077393	NOTCH3/EPN2/PARVA/FMNL2/IDH1/UBFD1/BMPR2/CTNND1/PTPRM	9
GO:0008022	protein C-terminus binding	6/275	189/18367	0.0652805373668458	0.526315301342709	SYT1/PPP1R9A/BCAM/DST/SP1/PIAS3	6
GO:0070325	lipoprotein particle receptor binding	2/275	28/18367	0.0654337942209855	0.526315301342709	SYT1/CLU	2
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/275	30/18367	0.0738644325048071	0.585639429145256	SLC26A2/SLC19A1	2
GO:0140318	protein transporter activity	2/275	31/18367	0.0782033403273985	0.607427550820184	LRP2/ABCA1	2
GO:0004222	metalloendopeptidase activity	4/275	111/18367	0.0855172362678213	0.607427550820184	ADAMTS19/ADAMTS6/ADAM15/ADAM9	4
GO:0019956	chemokine binding	2/275	33/18367	0.0871114995297014	0.607427550820184	CXCR2/ITGAV	2
GO:0008376	acetylgalactosaminyltransferase activity	2/275	34/18367	0.0916742622021325	0.607427550820184	GALNT3/GBGT1	2
GO:0046943	carboxylic acid transmembrane transporter activity	5/275	163/18367	0.0985974234308166	0.607427550820184	SLC16A12/SLC26A2/SLC19A2/SLC19A1/SLC38A5	5
GO:0019905	syntaxin binding	3/275	74/18367	0.0994492268442062	0.607427550820184	SYT1/SYT8/ABCA1	3
GO:0005342	organic acid transmembrane transporter activity	5/275	164/18367	0.100528928608995	0.607427550820184	SLC16A12/SLC26A2/SLC19A2/SLC19A1/SLC38A5	5
GO:0015248	sterol transporter activity	2/275	36/18367	0.101001523937811	0.607427550820184	STARD4/ABCA1	2
GO:0016874	ligase activity	5/275	165/18367	0.102479355704489	0.607427550820184	CTPS2/TTLL1/YARS2/ATG7/ACSL1	5
GO:0030551	cyclic nucleotide binding	2/275	37/18367	0.105760001097684	0.607427550820184	PDE10A/SLC19A1	2
GO:0051015	actin filament binding	6/275	217/18367	0.108295314065141	0.607427550820184	MYO5B/PPP1R9A/GAS7/ACTR3C/TMEM201/FMNL2	6
GO:0038024	cargo receptor activity	3/275	77/18367	0.10872876072248	0.607427550820184	ASGR1/LRP2/ABCA1	3
GO:0140303	intramembrane lipid transporter activity	2/275	38/18367	0.110577818605117	0.607427550820184	ATP8B1/ABCA1	2
GO:0030246	carbohydrate binding	7/275	271/18367	0.113623517642565	0.607427550820184	ASGR1/KLRG2/P3H2/MANBA/LMAN2L/CLN5/GALNT3	7
GO:0005525	GTP binding	9/275	377/18367	0.114489501640003	0.607427550820184	EHD3/MOCS1/RAB9B/IRGQ/RP2/IFT22/RAB15/RAB23/DNM1L	9
GO:0005085	guanyl-nucleotide exchange factor activity	6/275	223/18367	0.119046567916392	0.607427550820184	PLEKHG4B/PLEKHG1/RGL1/RALGPS1/RASGEF1B/ARHGEF12	6
GO:0042169	SH2 domain binding	2/275	40/18367	0.120380236938814	0.607427550820184	IRS1/PTK2	2
GO:0042826	histone deacetylase binding	4/275	127/18367	0.123468141267494	0.607427550820184	GLI3/BHLHE41/SP1/GMNN	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/275	41/18367	0.125359394420522	0.607427550820184	ATG7/ACSL1	2
GO:0008013	beta-catenin binding	3/275	85/18367	0.134992849296713	0.607427550820184	GJA1/GLI3/KANK1	3
GO:0140297	DNA-binding transcription factor binding	9/275	394/18367	0.138647291847011	0.607427550820184	TEAD3/TACC2/HIRA/ISL1/BHLHE41/TWIST1/SP1/GMNN/SETD6	9
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/275	10/18367	0.140061581911424	0.607427550820184	ATG7	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/275	10/18367	0.140061581911424	0.607427550820184	SLC38A5	1
GO:0015232	heme transmembrane transporter activity	1/275	10/18367	0.140061581911424	0.607427550820184	FLVCR2	1
GO:0017002	activin-activated receptor activity	1/275	10/18367	0.140061581911424	0.607427550820184	BMPR2	1
GO:0019531	oxalate transmembrane transporter activity	1/275	10/18367	0.140061581911424	0.607427550820184	SLC26A2	1
GO:0043139	5'-3' DNA helicase activity	1/275	10/18367	0.140061581911424	0.607427550820184	DDX11	1
GO:0050786	RAGE receptor binding	1/275	10/18367	0.140061581911424	0.607427550820184	S100A8	1
GO:0051880	G-quadruplex DNA binding	1/275	10/18367	0.140061581911424	0.607427550820184	DDX11	1
GO:0070739	protein-glutamic acid ligase activity	1/275	10/18367	0.140061581911424	0.607427550820184	TTLL1	1
GO:0070740	tubulin-glutamic acid ligase activity	1/275	10/18367	0.140061581911424	0.607427550820184	TTLL1	1
GO:0120016	sphingolipid transfer activity	1/275	10/18367	0.140061581911424	0.607427550820184	PLEKHA8	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	2/275	44/18367	0.140577425680133	0.607427550820184	PAK3/MAP3K9	2
GO:0002020	protease binding	4/275	135/18367	0.144712950991236	0.607427550820184	ADAMTSL4/ITGA3/SERPINE1/ITGAV	4
GO:0043177	organic acid binding	4/275	135/18367	0.144712950991236	0.607427550820184	S100A8/P3H2/YARS2/SLC19A1	4
GO:0008276	protein methyltransferase activity	3/275	88/18367	0.145357599181758	0.607427550820184	N6AMT1/PRMT7/SETD6	3
GO:0048306	calcium-dependent protein binding	3/275	88/18367	0.145357599181758	0.607427550820184	SYT1/S100A8/TNNT3	3
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2/275	45/18367	0.145735328992552	0.607427550820184	WEE1/PTK2	2
GO:0005245	voltage-gated calcium channel activity	2/275	45/18367	0.145735328992552	0.607427550820184	TMC1/ITGAV	2
GO:0008081	phosphoric diester hydrolase activity	3/275	89/18367	0.148869399815397	0.607427550820184	PDE10A/PLCXD1/PLD6	3
GO:0015297	antiporter activity	3/275	89/18367	0.148869399815397	0.607427550820184	SLC4A2/SLC26A2/SLC19A1	3
GO:0043178	alcohol binding	3/275	89/18367	0.148869399815397	0.607427550820184	NR1H3/STARD4/ABCA1	3
GO:0000774	adenyl-nucleotide exchange factor activity	1/275	11/18367	0.152944028115834	0.607427550820184	HSPBP1	1
GO:0008503	benzodiazepine receptor activity	1/275	11/18367	0.152944028115834	0.607427550820184	GABRE	1
GO:0016273	arginine N-methyltransferase activity	1/275	11/18367	0.152944028115834	0.607427550820184	PRMT7	1
GO:0016274	protein-arginine N-methyltransferase activity	1/275	11/18367	0.152944028115834	0.607427550820184	PRMT7	1
GO:0022889	serine transmembrane transporter activity	1/275	11/18367	0.152944028115834	0.607427550820184	SLC38A5	1
GO:0035673	oligopeptide transmembrane transporter activity	1/275	11/18367	0.152944028115834	0.607427550820184	GJA1	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/275	11/18367	0.152944028115834	0.607427550820184	TXNRD2	1
GO:0047676	arachidonate-CoA ligase activity	1/275	11/18367	0.152944028115834	0.607427550820184	ACSL1	1
GO:0051400	BH domain binding	1/275	11/18367	0.152944028115834	0.607427550820184	DNM1L	1
GO:0061665	SUMO ligase activity	1/275	11/18367	0.152944028115834	0.607427550820184	PIAS3	1
GO:0102545	phosphatidyl phospholipase B activity	1/275	11/18367	0.152944028115834	0.607427550820184	PLB1	1
GO:1901612	cardiolipin binding	1/275	11/18367	0.152944028115834	0.607427550820184	ATP8B1	1
GO:0008237	metallopeptidase activity	5/275	190/18367	0.15700328097287	0.607427550820184	ADAMTS19/ENPEP/ADAMTS6/ADAM15/ADAM9	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/275	48/18367	0.161431646949678	0.607427550820184	CTPS2/TTLL1	2
GO:0070888	E-box binding	2/275	48/18367	0.161431646949678	0.607427550820184	BHLHE41/TWIST1	2
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	7/275	299/18367	0.162905078809739	0.607427550820184	TEAD3/TACC2/HIRA/ISL1/BHLHE41/SP1/SETD6	7
GO:0072341	modified amino acid binding	3/275	93/18367	0.163182286192574	0.607427550820184	SYT1/SLC19A1/SYT8	3
GO:0003995	acyl-CoA dehydrogenase activity	1/275	12/18367	0.165634178054173	0.607427550820184	ACADS	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/275	12/18367	0.165634178054173	0.607427550820184	HEXIM2	1
GO:0005165	neurotrophin receptor binding	1/275	12/18367	0.165634178054173	0.607427550820184	EFNA5	1
GO:0008174	mRNA methyltransferase activity	1/275	12/18367	0.165634178054173	0.607427550820184	TRMT61B	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/275	12/18367	0.165634178054173	0.607427550820184	EXO5	1
GO:0022858	alanine transmembrane transporter activity	1/275	12/18367	0.165634178054173	0.607427550820184	SLC38A5	1
GO:0031543	peptidyl-proline dioxygenase activity	1/275	12/18367	0.165634178054173	0.607427550820184	P3H2	1
GO:0035325	Toll-like receptor binding	1/275	12/18367	0.165634178054173	0.607427550820184	S100A8	1
GO:0045295	gamma-catenin binding	1/275	12/18367	0.165634178054173	0.607427550820184	DSC3	1
GO:0061578	Lys63-specific deubiquitinase activity	1/275	12/18367	0.165634178054173	0.607427550820184	USP27X	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	4/275	144/18367	0.170176480656611	0.607427550820184	TLR3/NAGLU/MANBA/CLN5	4
GO:0008170	N-methyltransferase activity	3/275	97/18367	0.17788676646805	0.607427550820184	N6AMT1/PRMT7/SETD6	3
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/275	13/18367	0.178134891812555	0.607427550820184	PPP1R14A	1
GO:0005542	folic acid binding	1/275	13/18367	0.178134891812555	0.607427550820184	SLC19A1	1
GO:0008035	high-density lipoprotein particle binding	1/275	13/18367	0.178134891812555	0.607427550820184	ABCA1	1
GO:0008195	phosphatidate phosphatase activity	1/275	13/18367	0.178134891812555	0.607427550820184	PLPP3	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/275	13/18367	0.178134891812555	0.607427550820184	TXNRD2	1
GO:0022851	GABA-gated chloride ion channel activity	1/275	13/18367	0.178134891812555	0.607427550820184	GABRE	1
GO:0140299	small molecule sensor activity	1/275	13/18367	0.178134891812555	0.607427550820184	SYT1	1
GO:0140333	glycerophospholipid flippase activity	1/275	13/18367	0.178134891812555	0.607427550820184	ATP8B1	1
GO:0008146	sulfotransferase activity	2/275	52/18367	0.182797439676983	0.607427550820184	CHST3/TPST2	2
GO:0050661	NADP binding	2/275	53/18367	0.188203189608982	0.607427550820184	SPR/IDH1	2
GO:0005496	steroid binding	3/275	100/18367	0.189145521851496	0.607427550820184	NR1H3/STARD4/ABCA1	3
GO:0004089	carbonate dehydratase activity	1/275	14/18367	0.190448987091598	0.607427550820184	CA2	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/275	14/18367	0.190448987091598	0.607427550820184	IRS1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/275	14/18367	0.190448987091598	0.607427550820184	B3GNT3	1
GO:0015373	anion:sodium symporter activity	1/275	14/18367	0.190448987091598	0.607427550820184	SLC13A4	1
GO:0015562	efflux transmembrane transporter activity	1/275	14/18367	0.190448987091598	0.607427550820184	GJA1	1
GO:0036041	long-chain fatty acid binding	1/275	14/18367	0.190448987091598	0.607427550820184	S100A8	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	1/275	14/18367	0.190448987091598	0.607427550820184	PDE10A	1
GO:0071837	HMG box domain binding	1/275	14/18367	0.190448987091598	0.607427550820184	SP1	1
GO:0005544	calcium-dependent phospholipid binding	2/275	54/18367	0.193630765118397	0.607427550820184	SYT1/SYT8	2
GO:0008408	3'-5' exonuclease activity	2/275	54/18367	0.193630765118397	0.607427550820184	EXO5/EXD3	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	2/275	54/18367	0.193630765118397	0.607427550820184	P3H2/KDM5B	2
GO:0015103	inorganic anion transmembrane transporter activity	4/275	152/18367	0.194020111314608	0.607427550820184	GABRE/SLC4A2/SLC13A4/SLC26A2	4
GO:0005319	lipid transporter activity	4/275	154/18367	0.200138145287024	0.607427550820184	ATP8B1/STARD4/PLEKHA8/ABCA1	4
GO:0001846	opsonin binding	1/275	15/18367	0.202579239832284	0.607427550820184	ITGAV	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/275	15/18367	0.202579239832284	0.607427550820184	PDE10A	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/275	15/18367	0.202579239832284	0.607427550820184	ACSL1	1
GO:0005041	low-density lipoprotein particle receptor activity	1/275	15/18367	0.202579239832284	0.607427550820184	LRP2	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/275	15/18367	0.202579239832284	0.607427550820184	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/275	15/18367	0.202579239832284	0.607427550820184	SLC4A2	1
GO:0015929	hexosaminidase activity	1/275	15/18367	0.202579239832284	0.607427550820184	NAGLU	1
GO:0017136	NAD-dependent histone deacetylase activity	1/275	15/18367	0.202579239832284	0.607427550820184	SIRT3	1
GO:0030553	cGMP binding	1/275	15/18367	0.202579239832284	0.607427550820184	PDE10A	1
GO:0051371	muscle alpha-actinin binding	1/275	15/18367	0.202579239832284	0.607427550820184	PRICKLE4	1
GO:1901611	phosphatidylglycerol binding	1/275	15/18367	0.202579239832284	0.607427550820184	ATP8B1	1
GO:1904680	peptide transmembrane transporter activity	1/275	15/18367	0.202579239832284	0.607427550820184	GJA1	1
GO:0042054	histone methyltransferase activity	2/275	56/18367	0.204544017618826	0.607427550820184	N6AMT1/PRMT7	2
GO:0051287	NAD binding	2/275	56/18367	0.204544017618826	0.607427550820184	IDH1/SIRT3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	4/275	156/18367	0.206313734446893	0.607427550820184	N6AMT1/PRMT7/TRMT61B/SETD6	4
GO:0003688	DNA replication origin binding	1/275	16/18367	0.214528384832617	0.607427550820184	DDX11	1
GO:0005159	insulin-like growth factor receptor binding	1/275	16/18367	0.214528384832617	0.607427550820184	IRS1	1
GO:0005521	lamin binding	1/275	16/18367	0.214528384832617	0.607427550820184	TMEM201	1
GO:0005523	tropomyosin binding	1/275	16/18367	0.214528384832617	0.607427550820184	TNNT3	1
GO:0010181	FMN binding	1/275	16/18367	0.214528384832617	0.607427550820184	TYW1	1
GO:0015923	mannosidase activity	1/275	16/18367	0.214528384832617	0.607427550820184	MANBA	1
GO:0016004	phospholipase activator activity	1/275	16/18367	0.214528384832617	0.607427550820184	PDPK1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/275	16/18367	0.214528384832617	0.607427550820184	SIRT3	1
GO:0036122	BMP binding	1/275	16/18367	0.214528384832617	0.607427550820184	BMPR2	1
GO:0042577	lipid phosphatase activity	1/275	16/18367	0.214528384832617	0.607427550820184	PLPP3	1
GO:0070403	NAD+ binding	1/275	16/18367	0.214528384832617	0.607427550820184	SIRT3	1
GO:0140327	flippase activity	1/275	16/18367	0.214528384832617	0.607427550820184	ATP8B1	1
GO:0019208	phosphatase regulator activity	3/275	107/18367	0.21607362838903	0.607427550820184	PPP1R14A/BMPR2/PPP1R12B	3
GO:0016279	protein-lysine N-methyltransferase activity	2/275	59/18367	0.221032791106529	0.607427550820184	N6AMT1/SETD6	2
GO:0098631	cell adhesion mediator activity	2/275	59/18367	0.221032791106529	0.607427550820184	JAM3/BCAM	2
GO:0046982	protein heterodimerization activity	7/275	328/18367	0.222290464496047	0.607427550820184	SYT1/ABTB2/JAM3/BHLHE41/ITGA3/TENM3/KATNB1	7
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/275	17/18367	0.226299116355206	0.607427550820184	PTPRM	1
GO:0008381	mechanosensitive ion channel activity	1/275	17/18367	0.226299116355206	0.607427550820184	TMC1	1
GO:0015095	magnesium ion transmembrane transporter activity	1/275	17/18367	0.226299116355206	0.607427550820184	ZDHHC13	1
GO:0015108	chloride transmembrane transporter activity	1/275	17/18367	0.226299116355206	0.607427550820184	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/275	17/18367	0.226299116355206	0.607427550820184	SLC38A5	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/275	17/18367	0.226299116355206	0.607427550820184	PTPRM	1
GO:0034185	apolipoprotein binding	1/275	17/18367	0.226299116355206	0.607427550820184	ABCA1	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/275	17/18367	0.226299116355206	0.607427550820184	B3GNT3	1
GO:0070064	proline-rich region binding	1/275	17/18367	0.226299116355206	0.607427550820184	GAREM1	1
GO:0001786	phosphatidylserine binding	2/275	60/18367	0.226554059495096	0.607427550820184	SYT1/SYT8	2
GO:0016278	lysine N-methyltransferase activity	2/275	60/18367	0.226554059495096	0.607427550820184	N6AMT1/SETD6	2
GO:0000149	SNARE binding	3/275	110/18367	0.227853393297189	0.60797419846125	SYT1/SYT8/ABCA1	3
GO:0005507	copper ion binding	2/275	61/18367	0.232085178227269	0.61125564464295	SNCG/F5	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/275	18/18367	0.237894088725905	0.61125564464295	SLC19A1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/275	18/18367	0.237894088725905	0.61125564464295	SLC19A1	1
GO:0008409	5'-3' exonuclease activity	1/275	18/18367	0.237894088725905	0.61125564464295	EXO5	1
GO:0030228	lipoprotein particle receptor activity	1/275	18/18367	0.237894088725905	0.61125564464295	LRP2	1
GO:0060229	lipase activator activity	1/275	18/18367	0.237894088725905	0.61125564464295	PDPK1	1
GO:0099095	ligand-gated anion channel activity	1/275	18/18367	0.237894088725905	0.61125564464295	GABRE	1
GO:0140597	protein carrier activity	1/275	18/18367	0.237894088725905	0.61125564464295	CLU	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/275	19/18367	0.249315916923648	0.623732269018694	GALNT3	1
GO:0004890	GABA-A receptor activity	1/275	19/18367	0.249315916923648	0.623732269018694	GABRE	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/275	20/18367	0.260567177161602	0.623732269018694	PTDSS2	1
GO:0019211	phosphatase activator activity	1/275	20/18367	0.260567177161602	0.623732269018694	BMPR2	1
GO:0030296	protein tyrosine kinase activator activity	1/275	20/18367	0.260567177161602	0.623732269018694	EFNA5	1
GO:0031418	L-ascorbic acid binding	1/275	20/18367	0.260567177161602	0.623732269018694	P3H2	1
GO:0042288	MHC class I protein binding	1/275	20/18367	0.260567177161602	0.623732269018694	PILRA	1
GO:0061608	nuclear import signal receptor activity	1/275	20/18367	0.260567177161602	0.623732269018694	TMCO6	1
GO:0097001	ceramide binding	1/275	20/18367	0.260567177161602	0.623732269018694	PLEKHA8	1
GO:0005262	calcium channel activity	3/275	119/18367	0.263838576721851	0.623732269018694	TMC1/CATSPER2/ITGAV	3
GO:0016782	transferase activity, transferring sulphur-containing groups	2/275	68/18367	0.270955943233496	0.623732269018694	CHST3/TPST2	2
GO:0001614	purinergic nucleotide receptor activity	1/275	21/18367	0.271650407459774	0.623732269018694	P2RX7	1
GO:0004407	histone deacetylase activity	1/275	21/18367	0.271650407459774	0.623732269018694	SIRT3	1
GO:0005243	gap junction channel activity	1/275	21/18367	0.271650407459774	0.623732269018694	GJA1	1
GO:0008373	sialyltransferase activity	1/275	21/18367	0.271650407459774	0.623732269018694	ST3GAL6	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/275	21/18367	0.271650407459774	0.623732269018694	SLC19A1	1
GO:0016502	nucleotide receptor activity	1/275	21/18367	0.271650407459774	0.623732269018694	P2RX7	1
GO:0051010	microtubule plus-end binding	1/275	21/18367	0.271650407459774	0.623732269018694	DST	1
GO:0004857	enzyme inhibitor activity	2/275	70/18367	0.282070514159911	0.623732269018694	HSPBP1/PPP1R12B	2
GO:0004860	protein kinase inhibitor activity	2/275	70/18367	0.282070514159911	0.623732269018694	PARVA/HEXIM2	2
GO:0008320	protein transmembrane transporter activity	1/275	22/18367	0.282568108209178	0.623732269018694	ABCA1	1
GO:0008649	rRNA methyltransferase activity	1/275	22/18367	0.282568108209178	0.623732269018694	TRMT61B	1
GO:0015106	bicarbonate transmembrane transporter activity	1/275	22/18367	0.282568108209178	0.623732269018694	SLC26A2	1
GO:0015296	anion:cation symporter activity	1/275	22/18367	0.282568108209178	0.623732269018694	SLC13A4	1
GO:0015645	fatty acid ligase activity	1/275	22/18367	0.282568108209178	0.623732269018694	ACSL1	1
GO:0016881	acid-amino acid ligase activity	1/275	22/18367	0.282568108209178	0.623732269018694	TTLL1	1
GO:0016917	GABA receptor activity	1/275	22/18367	0.282568108209178	0.623732269018694	GABRE	1
GO:0017075	syntaxin-1 binding	1/275	22/18367	0.282568108209178	0.623732269018694	SYT1	1
GO:0030742	GTP-dependent protein binding	1/275	22/18367	0.282568108209178	0.623732269018694	DNM1L	1
GO:0033558	protein deacetylase activity	1/275	22/18367	0.282568108209178	0.623732269018694	SIRT3	1
GO:0140102	catalytic activity, acting on a rRNA	1/275	22/18367	0.282568108209178	0.623732269018694	TRMT61B	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3/275	124/18367	0.284131219363792	0.623732269018694	SDR42E1/SPR/IDH1	3
GO:0140101	catalytic activity, acting on a tRNA	3/275	124/18367	0.284131219363792	0.623732269018694	YARS2/TYW1/TRMT61B	3
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/275	71/18367	0.287623017771888	0.623732269018694	ASAH2B/SIRT3	2
GO:0015291	secondary active transmembrane transporter activity	5/275	240/18367	0.291170068562434	0.623732269018694	SLC16A12/SLC4A2/SLC13A4/SLC26A2/SLC19A1	5
GO:0000049	tRNA binding	2/275	72/18367	0.293170808744549	0.623732269018694	YARS2/XPOT	2
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/275	23/18367	0.29332274272771	0.623732269018694	PDE10A	1
GO:0004529	exodeoxyribonuclease activity	1/275	23/18367	0.29332274272771	0.623732269018694	EXO5	1
GO:0016493	C-C chemokine receptor activity	1/275	23/18367	0.29332274272771	0.623732269018694	CXCR2	1
GO:0016849	phosphorus-oxygen lyase activity	1/275	23/18367	0.29332274272771	0.623732269018694	MOCS1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/275	23/18367	0.29332274272771	0.623732269018694	EXO5	1
GO:0017134	fibroblast growth factor binding	1/275	23/18367	0.29332274272771	0.623732269018694	ITGAV	1
GO:0030215	semaphorin receptor binding	1/275	23/18367	0.29332274272771	0.623732269018694	SEMA4G	1
GO:0030552	cAMP binding	1/275	23/18367	0.29332274272771	0.623732269018694	PDE10A	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/275	23/18367	0.29332274272771	0.623732269018694	B3GNT3	1
GO:0005230	extracellular ligand-gated ion channel activity	2/275	73/18367	0.29871278688948	0.625398431880344	GABRE/P2RX7	2
GO:0140104	molecular carrier activity	2/275	73/18367	0.29871278688948	0.625398431880344	TMCO6/CLU	2
GO:0004622	lysophospholipase activity	1/275	24/18367	0.303916737807839	0.625398431880344	PLB1	1
GO:0019789	SUMO transferase activity	1/275	24/18367	0.303916737807839	0.625398431880344	PIAS3	1
GO:0019957	C-C chemokine binding	1/275	24/18367	0.303916737807839	0.625398431880344	CXCR2	1
GO:0043274	phospholipase binding	1/275	24/18367	0.303916737807839	0.625398431880344	PDPK1	1
GO:0070840	dynein complex binding	1/275	24/18367	0.303916737807839	0.625398431880344	KATNB1	1
GO:0120014	phospholipid transfer activity	1/275	24/18367	0.303916737807839	0.625398431880344	PLEKHA8	1
GO:0019210	kinase inhibitor activity	2/275	74/18367	0.304247885779627	0.625398431880344	PARVA/HEXIM2	2
GO:0003714	transcription corepressor activity	4/275	187/18367	0.307440163596477	0.626719455810569	HIRA/KDM5B/LMCD1/GMNN	4
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/275	25/18367	0.31435248425623	0.626719455810569	PDE10A	1
GO:0005227	calcium activated cation channel activity	1/275	25/18367	0.31435248425623	0.626719455810569	CATSPER2	1
GO:0001618	virus receptor activity	2/275	76/18367	0.315293344361245	0.626719455810569	ITGAV/SLC52A1	2
GO:0004175	endopeptidase activity	8/275	430/18367	0.316588640134029	0.626719455810569	ADAMTS19/ADAMTS6/PSEN2/ADAM15/HTRA4/CTSF/PRSS8/ADAM9	8
GO:0140272	exogenous protein binding	2/275	77/18367	0.320801733258278	0.626719455810569	ITGAV/SLC52A1	2
GO:0001637	G protein-coupled chemoattractant receptor activity	1/275	26/18367	0.324632337425434	0.626719455810569	CXCR2	1
GO:0004806	triglyceride lipase activity	1/275	26/18367	0.324632337425434	0.626719455810569	PLB1	1
GO:0004950	chemokine receptor activity	1/275	26/18367	0.324632337425434	0.626719455810569	CXCR2	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/275	26/18367	0.324632337425434	0.626719455810569	ZDHHC13	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/275	26/18367	0.324632337425434	0.626719455810569	ZDHHC13	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/275	26/18367	0.324632337425434	0.626719455810569	SLC26A2	1
GO:0015085	calcium ion transmembrane transporter activity	3/275	135/18367	0.329129171859051	0.626719455810569	TMC1/CATSPER2/ITGAV	3
GO:0015631	tubulin binding	7/275	375/18367	0.33093602530581	0.626719455810569	GJA1/LZTS1/S100A8/TTLL1/DST/KATNB1/DNM1L	7
GO:0008186	ATP-dependent activity, acting on RNA	2/275	79/18367	0.331785135500933	0.626719455810569	DHX57/DDX11	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3/275	136/18367	0.333226877446664	0.626719455810569	SDR42E1/SPR/IDH1	3
GO:0004190	aspartic-type endopeptidase activity	1/275	27/18367	0.334758617737741	0.626719455810569	PSEN2	1
GO:0004709	MAP kinase kinase kinase activity	1/275	27/18367	0.334758617737741	0.626719455810569	MAP3K9	1
GO:0015215	nucleotide transmembrane transporter activity	1/275	27/18367	0.334758617737741	0.626719455810569	SLC19A1	1
GO:0016405	CoA-ligase activity	1/275	27/18367	0.334758617737741	0.626719455810569	ACSL1	1
GO:0022884	macromolecule transmembrane transporter activity	1/275	27/18367	0.334758617737741	0.626719455810569	ABCA1	1
GO:0045499	chemorepellent activity	1/275	27/18367	0.334758617737741	0.626719455810569	SEMA4G	1
GO:0051393	alpha-actinin binding	1/275	27/18367	0.334758617737741	0.626719455810569	PRICKLE4	1
GO:0070006	metalloaminopeptidase activity	1/275	27/18367	0.334758617737741	0.626719455810569	ENPEP	1
GO:0004527	exonuclease activity	2/275	80/18367	0.337258360891148	0.626719455810569	EXO5/EXD3	2
GO:0016829	lyase activity	4/275	196/18367	0.337906942670052	0.626719455810569	PISD/MOCS1/TYW1/CA2	4
GO:0003785	actin monomer binding	1/275	28/18367	0.344733611201324	0.626719455810569	COBL	1
GO:0003953	NAD+ nucleosidase activity	1/275	28/18367	0.344733611201324	0.626719455810569	TLR3	1
GO:0015101	organic cation transmembrane transporter activity	1/275	28/18367	0.344733611201324	0.626719455810569	SLC19A2	1
GO:0046875	ephrin receptor binding	1/275	28/18367	0.344733611201324	0.626719455810569	EFNA5	1
GO:0051861	glycolipid binding	1/275	28/18367	0.344733611201324	0.626719455810569	PLEKHA8	1
GO:0070001	aspartic-type peptidase activity	1/275	28/18367	0.344733611201324	0.626719455810569	PSEN2	1
GO:0004033	aldo-keto reductase (NADP) activity	1/275	29/18367	0.354559569918791	0.626719455810569	SPR	1
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/275	29/18367	0.354559569918791	0.626719455810569	P2RX7	1
GO:0032452	histone demethylase activity	1/275	29/18367	0.354559569918791	0.626719455810569	KDM5B	1
GO:0035250	UDP-galactosyltransferase activity	1/275	29/18367	0.354559569918791	0.626719455810569	B3GNT3	1
GO:0046625	sphingolipid binding	1/275	29/18367	0.354559569918791	0.626719455810569	PLEKHA8	1
GO:0051059	NF-kappaB binding	1/275	29/18367	0.354559569918791	0.626719455810569	SETD6	1
GO:0051787	misfolded protein binding	1/275	29/18367	0.354559569918791	0.626719455810569	CLU	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/275	29/18367	0.354559569918791	0.626719455810569	PLEKHA8	1
GO:0140457	protein demethylase activity	1/275	29/18367	0.354559569918791	0.626719455810569	KDM5B	1
GO:0005244	voltage-gated ion channel activity	4/275	201/18367	0.354893346773178	0.626719455810569	TMC1/CATSPER2/KCNG1/ITGAV	4
GO:0022832	voltage-gated channel activity	4/275	201/18367	0.354893346773178	0.626719455810569	TMC1/CATSPER2/KCNG1/ITGAV	4
GO:0030165	PDZ domain binding	2/275	84/18367	0.359008567706657	0.626719455810569	GJA1/CRIM1	2
GO:0008194	UDP-glycosyltransferase activity	3/275	143/18367	0.361861244830547	0.626719455810569	B3GNT3/GALNT3/GBGT1	3
GO:0022843	voltage-gated cation channel activity	3/275	143/18367	0.361861244830547	0.626719455810569	TMC1/KCNG1/ITGAV	3
GO:0016417	S-acyltransferase activity	1/275	30/18367	0.364238712588239	0.626719455810569	ZDHHC13	1
GO:0022829	wide pore channel activity	1/275	30/18367	0.364238712588239	0.626719455810569	GJA1	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/275	30/18367	0.364238712588239	0.626719455810569	SDR42E1	1
GO:0050660	flavin adenine dinucleotide binding	2/275	85/18367	0.364406536824969	0.626719455810569	TXNRD2/ACADS	2
GO:1901681	sulfur compound binding	5/275	265/18367	0.364732989513737	0.626719455810569	FBN1/CCDC80/N6AMT1/NRP2/SETD6	5
GO:0019887	protein kinase regulator activity	4/275	204/18367	0.365087613239552	0.626719455810569	EFNA5/PARVA/BMPR2/HEXIM2	4
GO:0016247	channel regulator activity	3/275	145/18367	0.370013753184076	0.626719455810569	CNIH3/PRSS8/PIAS3	3
GO:0000146	microfilament motor activity	1/275	31/18367	0.373773224996934	0.626719455810569	MYO5B	1
GO:0008157	protein phosphatase 1 binding	1/275	31/18367	0.373773224996934	0.626719455810569	PPP1R9A	1
GO:0016878	acid-thiol ligase activity	1/275	31/18367	0.373773224996934	0.626719455810569	ACSL1	1
GO:0031210	phosphatidylcholine binding	1/275	31/18367	0.373773224996934	0.626719455810569	ABCA1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/275	31/18367	0.373773224996934	0.626719455810569	SLC19A1	1
GO:0071813	lipoprotein particle binding	1/275	31/18367	0.373773224996934	0.626719455810569	ABCA1	1
GO:0071814	protein-lipid complex binding	1/275	31/18367	0.373773224996934	0.626719455810569	ABCA1	1
GO:0140142	nucleocytoplasmic carrier activity	1/275	31/18367	0.373773224996934	0.626719455810569	TMCO6	1
GO:0008017	microtubule binding	5/275	271/18367	0.382545137503768	0.631028841488981	LZTS1/S100A8/DST/KATNB1/DNM1L	5
GO:0008175	tRNA methyltransferase activity	1/275	32/18367	0.383165260507724	0.631028841488981	TRMT61B	1
GO:0008378	galactosyltransferase activity	1/275	32/18367	0.383165260507724	0.631028841488981	B3GNT3	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/275	32/18367	0.383165260507724	0.631028841488981	SLC19A1	1
GO:0050699	WW domain binding	1/275	32/18367	0.383165260507724	0.631028841488981	PRRG4	1
GO:0071889	14-3-3 protein binding	1/275	32/18367	0.383165260507724	0.631028841488981	TMCC3	1
GO:0004518	nuclease activity	4/275	210/18367	0.385449540044469	0.631522017429698	EXO5/TSEN15/PLD6/EXD3	4
GO:0019903	protein phosphatase binding	3/275	150/18367	0.390306389526534	0.631522017429698	PPP1R9A/MET/PTK2	3
GO:0140677	molecular function activator activity	3/275	150/18367	0.390306389526534	0.631522017429698	BMPR2/PDPK1/PPP1R12B	3
GO:0001530	lipopolysaccharide binding	1/275	33/18367	0.392416940538287	0.631522017429698	P2RX7	1
GO:0004623	phospholipase A2 activity	1/275	33/18367	0.392416940538287	0.631522017429698	PLB1	1
GO:0005154	epidermal growth factor receptor binding	1/275	33/18367	0.392416940538287	0.631522017429698	BTC	1
GO:0005251	delayed rectifier potassium channel activity	1/275	33/18367	0.392416940538287	0.631522017429698	KCNG1	1
GO:0005543	phospholipid binding	8/275	466/18367	0.397777090129247	0.631522017429698	SYT1/PARD3B/ATP8B1/EPN2/PLEKHA8/SYT8/GRB7/ABCA1	8
GO:0008168	methyltransferase activity	4/275	214/18367	0.398983424185282	0.631522017429698	N6AMT1/PRMT7/TRMT61B/SETD6	4
GO:0022836	gated channel activity	6/275	340/18367	0.400179108707614	0.631522017429698	TMC1/CATSPER2/GABRE/KCNG1/P2RX7/ITGAV	6
GO:0016229	steroid dehydrogenase activity	1/275	34/18367	0.401530355033322	0.631522017429698	SDR42E1	1
GO:0016831	carboxy-lyase activity	1/275	34/18367	0.401530355033322	0.631522017429698	PISD	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/275	34/18367	0.401530355033322	0.631522017429698	PLD6	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/275	34/18367	0.401530355033322	0.631522017429698	HEXIM2	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/275	34/18367	0.401530355033322	0.631522017429698	IRS1	1
GO:0051213	dioxygenase activity	2/275	92/18367	0.401670760635466	0.631522017429698	P3H2/KDM5B	2
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	2/275	94/18367	0.412131588053944	0.646138506694743	NAGLU/MANBA	2
GO:0042805	actinin binding	1/275	36/18367	0.419350592615269	0.653762862082792	PRICKLE4	1
GO:0097718	disordered domain specific binding	1/275	36/18367	0.419350592615269	0.653762862082792	GJA1	1
GO:0000287	magnesium ion binding	4/275	221/18367	0.42253932531177	0.656888867081324	ATP8B1/WEE1/RP2/IDH1	4
GO:0004896	cytokine receptor activity	2/275	97/18367	0.427651447719563	0.658100001442392	CXCR2/LIFR	2
GO:0005109	frizzled binding	1/275	37/18367	0.428061442379646	0.658100001442392	RNF43	1
GO:0015035	protein-disulfide reductase activity	1/275	37/18367	0.428061442379646	0.658100001442392	TXNRD2	1
GO:0016409	palmitoyltransferase activity	1/275	37/18367	0.428061442379646	0.658100001442392	ZDHHC13	1
GO:0004867	serine-type endopeptidase inhibitor activity	2/275	98/18367	0.432777126163829	0.663511892322997	CRIM1/SERPINE1	2
GO:0016741	transferase activity, transferring one-carbon groups	4/275	225/18367	0.435902851488653	0.663935218841977	N6AMT1/PRMT7/TRMT61B/SETD6	4
GO:0015175	neutral amino acid transmembrane transporter activity	1/275	38/18367	0.436642080860039	0.663935218841977	SLC38A5	1
GO:0019213	deacetylase activity	1/275	38/18367	0.436642080860039	0.663935218841977	SIRT3	1
GO:0005504	fatty acid binding	1/275	39/18367	0.445094447479248	0.671270158562453	S100A8	1
GO:0032451	demethylase activity	1/275	39/18367	0.445094447479248	0.671270158562453	KDM5B	1
GO:0050997	quaternary ammonium group binding	1/275	39/18367	0.445094447479248	0.671270158562453	ABCA1	1
GO:0030295	protein kinase activator activity	2/275	101/18367	0.448005263810912	0.673627882754116	EFNA5/BMPR2	2
GO:0005539	glycosaminoglycan binding	4/275	230/18367	0.452483956617665	0.673627882754116	FBN1/CCDC80/NRP2/GNS	4
GO:0004177	aminopeptidase activity	1/275	40/18367	0.45342045287772	0.673627882754116	ENPEP	1
GO:0017080	sodium channel regulator activity	1/275	40/18367	0.45342045287772	0.673627882754116	PRSS8	1
GO:0042287	MHC protein binding	1/275	40/18367	0.45342045287772	0.673627882754116	PILRA	1
GO:0008201	heparin binding	3/275	166/18367	0.453940230900972	0.673627882754116	FBN1/CCDC80/NRP2	3
GO:0004812	aminoacyl-tRNA ligase activity	1/275	41/18367	0.461621979339151	0.678010677357966	YARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/275	41/18367	0.461621979339151	0.678010677357966	YARS2	1
GO:0030331	estrogen receptor binding	1/275	41/18367	0.461621979339151	0.678010677357966	ISL1	1
GO:0019207	kinase regulator activity	4/275	233/18367	0.462357844593703	0.678010677357966	EFNA5/PARVA/BMPR2/HEXIM2	4
GO:0004620	phospholipase activity	2/275	104/18367	0.463001885979584	0.678010677357966	PLB1/PLD6	2
GO:1990782	protein tyrosine kinase binding	2/275	105/18367	0.467947655212492	0.682418819558758	IRS1/BMPR2	2
GO:0015036	disulfide oxidoreductase activity	1/275	42/18367	0.469700881209812	0.682418819558758	TXNRD2	1
GO:0019894	kinesin binding	1/275	42/18367	0.469700881209812	0.682418819558758	DISC1	1
GO:0018024	histone-lysine N-methyltransferase activity	1/275	43/18367	0.477658985311711	0.688715535856352	N6AMT1	1
GO:0019209	kinase activator activity	2/275	107/18367	0.477757623972424	0.688715535856352	EFNA5/BMPR2	2
GO:0051087	chaperone binding	2/275	107/18367	0.477757623972424	0.688715535856352	LRP2/CLU	2
GO:0001784	phosphotyrosine residue binding	1/275	44/18367	0.485498091349654	0.690901129997585	IRS1	1
GO:0008375	acetylglucosaminyltransferase activity	1/275	44/18367	0.485498091349654	0.690901129997585	B3GNT3	1
GO:0022839	ion gated channel activity	1/275	44/18367	0.485498091349654	0.690901129997585	CATSPER2	1
GO:0051879	Hsp90 protein binding	1/275	44/18367	0.485498091349654	0.690901129997585	USP19	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/275	44/18367	0.485498091349654	0.690901129997585	GABRE	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2/275	109/18367	0.487456911667337	0.691914542136501	SLC26A2/ABCA1	2
GO:0008047	enzyme activator activity	2/275	110/18367	0.492264384229747	0.693005277552748	PDPK1/PPP1R12B	2
GO:0031406	carboxylic acid binding	3/275	176/18367	0.492303260665884	0.693005277552748	S100A8/P3H2/SLC19A1	3
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/275	45/18367	0.493219972312316	0.693005277552748	PLD6	1
GO:0048156	tau protein binding	1/275	45/18367	0.493219972312316	0.693005277552748	CLU	1
GO:0004864	protein phosphatase inhibitor activity	1/275	46/18367	0.500826374867392	0.701915752655057	PPP1R14A	1
GO:0004843	thiol-dependent deubiquitinase	2/275	113/18367	0.506515254546266	0.708100670713294	USP27X/USP19	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/275	47/18367	0.50831901975094	0.708836824024552	GABRE	1
GO:0101005	deubiquitinase activity	2/275	114/18367	0.511207644607325	0.710478585659099	USP27X/USP19	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	7/275	450/18367	0.51275956358692	0.710478585659099	NR1H3/ISL1/SIX4/CASZ1/PBX1/SP1/ZNF197	7
GO:0061659	ubiquitin-like protein ligase activity	5/275	316/18367	0.513336779908646	0.710478585659099	RNF43/TRIM60/RMND5B/PIAS3/ZNF598	5
GO:0015026	coreceptor activity	1/275	48/18367	0.515699602150967	0.711973331327827	ITGAV	1
GO:0019212	phosphatase inhibitor activity	1/275	49/18367	0.522969792085378	0.714133095387772	PPP1R14A	1
GO:0043539	protein serine/threonine kinase activator activity	1/275	49/18367	0.522969792085378	0.714133095387772	BMPR2	1
GO:0098632	cell-cell adhesion mediator activity	1/275	49/18367	0.522969792085378	0.714133095387772	JAM3	1
GO:0001216	DNA-binding transcription activator activity	7/275	456/18367	0.526799504880646	0.714133095387772	NR1H3/ISL1/SIX4/CASZ1/PBX1/SP1/ZNF197	7
GO:0005048	signal sequence binding	1/275	50/18367	0.530131234774346	0.714133095387772	KDELR3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/275	50/18367	0.530131234774346	0.714133095387772	SLC19A1	1
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/275	50/18367	0.530131234774346	0.714133095387772	HEXIM2	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/275	50/18367	0.530131234774346	0.714133095387772	TLR3	1
GO:0030159	signaling receptor complex adaptor activity	1/275	50/18367	0.530131234774346	0.714133095387772	IRS1	1
GO:0140359	ABC-type transporter activity	1/275	50/18367	0.530131234774346	0.714133095387772	ABCA1	1
GO:0008234	cysteine-type peptidase activity	3/275	190/18367	0.543674142266787	0.72594845508328	USP27X/CTSF/USP19	3
GO:0004879	nuclear receptor activity	1/275	52/18367	0.544134337503864	0.72594845508328	NR1H3	1
GO:0016597	amino acid binding	1/275	52/18367	0.544134337503864	0.72594845508328	YARS2	1
GO:0098531	ligand-activated transcription factor activity	1/275	52/18367	0.544134337503864	0.72594845508328	NR1H3	1
GO:0051082	unfolded protein binding	2/275	122/18367	0.547679313210354	0.728925704632486	CLU/RP2	2
GO:0017069	snRNA binding	1/275	53/18367	0.550979167271073	0.729817274070276	HEXIM2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/275	53/18367	0.550979167271073	0.729817274070276	SLC19A1	1
GO:0033218	amide binding	6/275	400/18367	0.555494503656123	0.734046308402734	ENPEP/KDELR3/TMEM158/CLU/PLEKHA8/SLC19A1	6
GO:0015459	potassium channel regulator activity	1/275	54/18367	0.557721589953199	0.734074398351134	PIAS3	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/275	125/18367	0.560858159704096	0.734074398351134	ASAH2B/SIRT3	2
GO:0019783	ubiquitin-like protein-specific protease activity	2/275	125/18367	0.560858159704096	0.734074398351134	USP27X/USP19	2
GO:0019902	phosphatase binding	3/275	196/18367	0.564753867015019	0.734074398351134	PPP1R9A/MET/PTK2	3
GO:0008242	omega peptidase activity	2/275	126/18367	0.565189946024851	0.734074398351134	USP27X/USP19	2
GO:0005261	cation channel activity	5/275	335/18367	0.565238913018171	0.734074398351134	TMC1/CATSPER2/KCNG1/P2RX7/ITGAV	5
GO:0016758	hexosyltransferase activity	3/275	197/18367	0.56820929908633	0.734074398351134	B3GNT3/GALNT3/GBGT1	3
GO:0022853	active ion transmembrane transporter activity	4/275	267/18367	0.5689623810688	0.734074398351134	SLC4A2/SLC13A4/SLC26A2/SLC19A1	4
GO:0022804	active transmembrane transporter activity	6/275	406/18367	0.570090260193685	0.734074398351134	SLC16A12/SLC4A2/SLC13A4/SLC26A2/SLC19A1/ABCA1	6
GO:0003924	GTPase activity	5/275	337/18367	0.570540136430164	0.734074398351134	RAB9B/IFT22/RAB15/RAB23/DNM1L	5
GO:0045309	protein phosphorylated amino acid binding	1/275	56/18367	0.570905297897263	0.734074398351134	IRS1	1
GO:0140678	molecular function inhibitor activity	2/275	128/18367	0.573761378308284	0.734074398351134	HSPBP1/PPP1R12B	2
GO:0004536	deoxyribonuclease activity	1/275	57/18367	0.577349568722354	0.734074398351134	EXO5	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/275	57/18367	0.577349568722354	0.734074398351134	TXNRD2	1
GO:0016757	glycosyltransferase activity	4/275	270/18367	0.577806702987131	0.734074398351134	ST3GAL6/B3GNT3/GALNT3/GBGT1	4
GO:0016298	lipase activity	2/275	129/18367	0.578000922665668	0.734074398351134	PLB1/PLD6	2
GO:0031072	heat shock protein binding	2/275	129/18367	0.578000922665668	0.734074398351134	TOMM34/USP19	2
GO:0035091	phosphatidylinositol binding	4/275	271/18367	0.580731969885758	0.734585168620142	SYT1/PARD3B/PLEKHA8/GRB7	4
GO:0015267	channel activity	7/275	480/18367	0.581300262756082	0.734585168620142	GJA1/TMC1/CATSPER2/GABRE/KCNG1/P2RX7/ITGAV	7
GO:0022803	passive transmembrane transporter activity	7/275	481/18367	0.583506418762058	0.734585168620142	GJA1/TMC1/CATSPER2/GABRE/KCNG1/P2RX7/ITGAV	7
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/275	58/18367	0.583697404254924	0.734585168620142	SLC16A12	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/275	59/18367	0.589950242412655	0.7407746256539	EXO5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/275	60/18367	0.596109499750241	0.743462409800862	ACADS	1
GO:0022824	transmitter-gated ion channel activity	1/275	60/18367	0.596109499750241	0.743462409800862	GABRE	1
GO:0022835	transmitter-gated channel activity	1/275	60/18367	0.596109499750241	0.743462409800862	GABRE	1
GO:0003712	transcription coregulator activity	7/275	489/18367	0.600950110087186	0.747668897842217	HIRA/SS18L1/KDM5B/LMCD1/GMNN/PIAS3/MED23	7
GO:0015179	L-amino acid transmembrane transporter activity	1/275	61/18367	0.602176571775624	0.747668897842217	SLC38A5	1
GO:0098960	postsynaptic neurotransmitter receptor activity	1/275	62/18367	0.608152833261568	0.751725662494812	GABRE	1
GO:1990841	promoter-specific chromatin binding	1/275	62/18367	0.608152833261568	0.751725662494812	ISL1	1
GO:0099106	ion channel regulator activity	2/275	139/18367	0.618697912138788	0.762772214271726	PRSS8/PIAS3	2
GO:0016836	hydro-lyase activity	1/275	64/18367	0.619838321867654	0.762772214271726	CA2	1
GO:0008173	RNA methyltransferase activity	1/275	65/18367	0.625550197597666	0.765282818781816	TRMT61B	1
GO:0030145	manganese ion binding	1/275	65/18367	0.625550197597666	0.765282818781816	GALNT3	1
GO:0046873	metal ion transmembrane transporter activity	6/275	430/18367	0.626015134643144	0.765282818781816	TMC1/CATSPER2/SLC13A4/KCNG1/ITGAV/ZDHHC13	6
GO:0005216	ion channel activity	6/275	432/18367	0.630484543246409	0.767958867507513	TMC1/CATSPER2/GABRE/KCNG1/P2RX7/ITGAV	6
GO:0043022	ribosome binding	1/275	66/18367	0.631176560599559	0.767958867507513	ZNF598	1
GO:0015276	ligand-gated ion channel activity	2/275	143/18367	0.634113067939097	0.767958867507513	GABRE/P2RX7	2
GO:0022834	ligand-gated channel activity	2/275	143/18367	0.634113067939097	0.767958867507513	GABRE/P2RX7	2
GO:0015293	symporter activity	2/275	144/18367	0.637890158416151	0.767958867507513	SLC16A12/SLC13A4	2
GO:0016922	nuclear receptor binding	2/275	144/18367	0.637890158416151	0.767958867507513	TACC2/ISL1	2
GO:0140375	immune receptor activity	2/275	144/18367	0.637890158416151	0.767958867507513	CXCR2/LIFR	2
GO:0042578	phosphoric ester hydrolase activity	5/275	366/18367	0.643424593317259	0.772945128335668	PDE10A/PLCXD1/PLPP3/PTPRM/PLD6	5
GO:0004521	endoribonuclease activity	1/275	69/18367	0.647555234837498	0.776227117353804	PLD6	1
GO:0052689	carboxylic ester hydrolase activity	2/275	147/18367	0.649038291016989	0.776328128263856	PLB1/CA2	2
GO:0031625	ubiquitin protein ligase binding	4/275	297/18367	0.652547088356324	0.777349580872802	CLU/HSPBP1/USP19/DNM1L	4
GO:0019842	vitamin binding	2/275	148/18367	0.652693521958064	0.777349580872802	P3H2/SLC19A1	2
GO:0043021	ribonucleoprotein complex binding	2/275	149/18367	0.656318474536667	0.779993047896895	PRMT7/ZNF598	2
GO:0031491	nucleosome binding	1/275	71/18367	0.658069673376967	0.780403138299608	HIRA	1
GO:0003678	DNA helicase activity	1/275	72/18367	0.663209094005592	0.783151164198093	DDX11	1
GO:0008235	metalloexopeptidase activity	1/275	72/18367	0.663209094005592	0.783151164198093	ENPEP	1
GO:0015370	solute:sodium symporter activity	1/275	73/18367	0.668271542715538	0.78335069879439	SLC13A4	1
GO:0033293	monocarboxylic acid binding	1/275	73/18367	0.668271542715538	0.78335069879439	S100A8	1
GO:0140097	catalytic activity, acting on DNA	3/275	229/18367	0.669519373463021	0.78335069879439	N6AMT1/DDX11/EXO5	3
GO:0061630	ubiquitin protein ligase activity	4/275	304/18367	0.670422809616142	0.78335069879439	RNF43/TRIM60/RMND5B/ZNF598	4
GO:0001653	peptide receptor activity	2/275	153/18367	0.67051723827554	0.78335069879439	CXCR2/OGFRL1	2
GO:0003725	double-stranded RNA binding	1/275	74/18367	0.673258168153017	0.78335069879439	TLR3	1
GO:0005254	chloride channel activity	1/275	74/18367	0.673258168153017	0.78335069879439	GABRE	1
GO:0019003	GDP binding	1/275	75/18367	0.678170101884932	0.787415076456354	RAB9B	1
GO:0004386	helicase activity	2/275	156/18367	0.680852898970496	0.788879663734082	DHX57/DDX11	2
GO:0019787	ubiquitin-like protein transferase activity	6/275	458/18367	0.685685692440897	0.791670573014652	RNF43/TRIM60/KLHL42/RMND5B/PIAS3/ZNF598	6
GO:0003724	RNA helicase activity	1/275	77/18367	0.68777433661762	0.791670573014652	DHX57	1
GO:0004674	protein serine/threonine kinase activity	5/275	386/18367	0.688967363542481	0.791670573014652	PAK3/MAP3K9/LTBP1/BMPR2/PDPK1	5
GO:0140098	catalytic activity, acting on RNA	5/275	386/18367	0.688967363542481	0.791670573014652	DHX57/YARS2/TYW1/TRMT61B/PLD6	5
GO:0001221	transcription coregulator binding	1/275	78/18367	0.692468817614348	0.792412770672089	SP1	1
GO:0030971	receptor tyrosine kinase binding	1/275	78/18367	0.692468817614348	0.792412770672089	IRS1	1
GO:0016835	carbon-oxygen lyase activity	1/275	79/18367	0.697092967385033	0.796062956581673	CA2	1
GO:0044389	ubiquitin-like protein ligase binding	4/275	316/18367	0.699578622588217	0.797261058596428	CLU/HSPBP1/USP19/DNM1L	4
GO:0035591	signaling adaptor activity	1/275	81/18367	0.706134457200187	0.80308324538136	IRS1	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	1/275	82/18367	0.71055385041193	0.803867274899303	SYT1	1
GO:0042393	histone binding	3/275	244/18367	0.710635309304544	0.803867274899303	HIRA/KDM5B/PRMT7	3
GO:0042277	peptide binding	4/275	321/18367	0.711169066622627	0.803867274899303	ENPEP/KDELR3/TMEM158/CLU	4
GO:0001540	amyloid-beta binding	1/275	84/18367	0.719194952342047	0.809641376368836	CLU	1
GO:0015171	amino acid transmembrane transporter activity	1/275	84/18367	0.719194952342047	0.809641376368836	SLC38A5	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	2/275	170/18367	0.725629669366017	0.814125688438033	P3H2/KDM5B	2
GO:0016209	antioxidant activity	1/275	86/18367	0.727578993631107	0.814125688438033	TXNRD2	1
GO:0042562	hormone binding	1/275	86/18367	0.727578993631107	0.814125688438033	LRP2	1
GO:0003727	single-stranded RNA binding	1/275	87/18367	0.731677006691194	0.815423170107656	DDX11	1
GO:0005253	anion channel activity	1/275	87/18367	0.731677006691194	0.815423170107656	GABRE	1
GO:1901981	phosphatidylinositol phosphate binding	2/275	173/18367	0.734506483142091	0.816158586763757	SYT1/PLEKHA8	2
GO:0051219	phosphoprotein binding	1/275	88/18367	0.735713594391408	0.816158586763757	IRS1	1
GO:0004252	serine-type endopeptidase activity	2/275	174/18367	0.737410819712385	0.816158586763757	HTRA4/PRSS8	2
GO:0019888	protein phosphatase regulator activity	1/275	89/18367	0.739689674130035	0.816158586763757	PPP1R14A	1
GO:0051117	ATPase binding	1/275	89/18367	0.739689674130035	0.816158586763757	ABCA1	1
GO:0005249	voltage-gated potassium channel activity	1/275	90/18367	0.743606149653301	0.818852010034885	KCNG1	1
GO:0004866	endopeptidase inhibitor activity	2/275	180/18367	0.754274364656289	0.828954994820278	CRIM1/SERPINE1	2
GO:0015399	primary active transmembrane transporter activity	2/275	181/18367	0.756992690456616	0.83029830672613	SLC26A2/ABCA1	2
GO:0030414	peptidase inhibitor activity	2/275	187/18367	0.772763852443661	0.845924927231226	CRIM1/SERPINE1	2
GO:0016887	ATP hydrolysis activity	3/275	272/18367	0.776709034229247	0.84856990944337	DHX57/ATP8B1/DDX11	3
GO:0004842	ubiquitin-protein transferase activity	5/275	433/18367	0.779857102394358	0.850335347404457	RNF43/TRIM60/KLHL42/RMND5B/ZNF598	5
GO:0008236	serine-type peptidase activity	2/275	191/18367	0.782777026621742	0.851845587794248	HTRA4/PRSS8	2
GO:0004725	protein tyrosine phosphatase activity	1/275	102/18367	0.786265916436444	0.852563519519535	PTPRM	1
GO:0005200	structural constituent of cytoskeleton	1/275	103/18367	0.789483922074548	0.852563519519535	EPB41L4B	1
GO:0008238	exopeptidase activity	1/275	103/18367	0.789483922074548	0.852563519519535	ENPEP	1
GO:0061135	endopeptidase regulator activity	2/275	194/18367	0.790031591023928	0.852563519519535	CRIM1/SERPINE1	2
GO:0017171	serine hydrolase activity	2/275	195/18367	0.792402056006416	0.852563519519535	HTRA4/PRSS8	2
GO:0015294	solute:cation symporter activity	1/275	104/18367	0.792653650580324	0.852563519519535	SLC13A4	1
GO:1902936	phosphatidylinositol bisphosphate binding	1/275	107/18367	0.801880336309465	0.860819316541108	SYT1	1
GO:0005516	calmodulin binding	2/275	201/18367	0.806135745943353	0.863716870653592	SYT1/MYO5B	2
GO:0047485	protein N-terminus binding	1/275	110/18367	0.810697871200289	0.866640782754228	PIAS3	1
GO:0008094	ATP-dependent activity, acting on DNA	1/275	111/18367	0.813549275342258	0.866640782754228	DDX11	1
GO:0030594	neurotransmitter receptor activity	1/275	111/18367	0.813549275342258	0.866640782754228	GABRE	1
GO:0099094	ligand-gated cation channel activity	1/275	113/18367	0.819124335475321	0.870470115226077	P2RX7	1
GO:0001664	G protein-coupled receptor binding	3/275	295/18367	0.82128489290115	0.870470115226077	RNF43/ITGB4/ARHGEF12	3
GO:0003774	cytoskeletal motor activity	1/275	114/18367	0.821849261943179	0.870470115226077	MYO5B	1
GO:0004540	ribonuclease activity	1/275	116/18367	0.827177013196101	0.874444271093021	PLD6	1
GO:0004197	cysteine-type endopeptidase activity	1/275	119/18367	0.834872427198847	0.880901515390418	CTSF	1
GO:0005267	potassium channel activity	1/275	121/18367	0.839812052344406	0.88443204753538	KCNG1	1
GO:0005179	hormone activity	1/275	122/18367	0.842226372502538	0.885294766550964	FBN1	1
GO:0003697	single-stranded DNA binding	1/275	123/18367	0.844604434851774	0.886116184012731	DDX11	1
GO:0004519	endonuclease activity	1/275	129/18367	0.858141218487735	0.898619577850364	PLD6	1
GO:0061134	peptidase regulator activity	2/275	230/18367	0.86173509332283	0.900683572117082	CRIM1/SERPINE1	2
GO:0044325	transmembrane transporter binding	1/275	133/18367	0.866506330354273	0.902569982573272	PPP1R9A	1
GO:0030546	signaling receptor activator activity	5/275	495/18367	0.866792433714512	0.902569982573272	EFNA5/SEMA4G/FBN1/BTC/BMPR2	5
GO:0020037	heme binding	1/275	139/18367	0.878141339549294	0.912674987733817	FLVCR2	1
GO:0070851	growth factor receptor binding	1/275	141/18367	0.881790588086719	0.914754722220801	BTC	1
GO:0008528	G protein-coupled peptide receptor activity	1/275	147/18367	0.892097808339602	0.923720678411341	CXCR2	1
GO:0046906	tetrapyrrole binding	1/275	149/18367	0.895330516592032	0.92534159536048	FLVCR2	1
GO:0005506	iron ion binding	1/275	151/18367	0.898466715796352	0.926715651941371	P3H2	1
GO:0015081	sodium ion transmembrane transporter activity	1/275	152/18367	0.899999525038556	0.926715651941371	SLC13A4	1
GO:0015079	potassium ion transmembrane transporter activity	1/275	155/18367	0.904460985848261	0.928806393185884	KCNG1	1
GO:0003713	transcription coactivator activity	2/275	262/18367	0.905907880308837	0.928806393185884	SS18L1/MED23	2
GO:0106310	protein serine kinase activity	3/275	360/18367	0.908463096690475	0.928806393185884	PAK3/MAP3K9/PDPK1	3
GO:0016853	isomerase activity	1/275	158/18367	0.908724092792675	0.928806393185884	PBLD	1
GO:0008083	growth factor activity	1/275	162/18367	0.914114817745024	0.932009675821222	BTC	1
GO:0005126	cytokine receptor binding	2/275	271/18367	0.915726814219106	0.932009675821222	EFNA5/LIFR	2
GO:0060090	molecular adaptor activity	3/275	369/18367	0.916896005402499	0.932009675821222	COL14A1/IRS1/DISC1	3
GO:0016791	phosphatase activity	2/275	275/18367	0.919775579921625	0.933227507964354	PLPP3/PTPRM	2
GO:0003823	antigen binding	1/275	171/18367	0.925112122437201	0.936929248088771	TSPAN4	1
GO:0004721	phosphoprotein phosphatase activity	1/275	174/18367	0.928456635777132	0.938603702834806	PTPRM	1
GO:0030674	protein-macromolecule adaptor activity	2/275	296/18367	0.938198266173602	0.946727341320635	COL14A1/IRS1	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	1/275	222/18367	0.965593097631916	0.972602847886957	ZDHHC13	1
GO:0016746	acyltransferase activity	1/275	250/18367	0.977571592192625	0.981730938312309	ZDHHC13	1
GO:0048018	receptor ligand activity	3/275	487/18367	0.978193169165237	0.981730938312309	SEMA4G/FBN1/BTC	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	1/275	310/18367	0.991055046937628	0.991457559281664	BHLHE41	1
GO:0001217	DNA-binding transcription repressor activity	1/275	313/18367	0.991457559281664	0.991457559281664	BHLHE41	1