ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0007229 integrin-mediated signaling pathway 11/255 107/18722 2.36097678994501e-07 0.00066145940330024 LAMA5/BCAR1/ITGA3/PLPP3/DST/ITGB4/ITGB8/ADAM15/ITGAV/PTK2/ADAM9 11 GO:0033627 cell adhesion mediated by integrin 9/255 72/18722 5.64497994917271e-07 0.00066145940330024 FBN1/JAM3/PLPP3/ITGB4/SERPINE1/ITGB8/ITGAV/PTK2/ADAM9 9 GO:0001667 ameboidal-type cell migration 22/255 475/18722 6.35001027168231e-07 0.00066145940330024 SEMA4G/GJA1/EPB41L4B/LAMA5/PAK3/MET/ISL1/BCAR1/ITGA3/PLPP3/TMEM201/TWIST1/ITGB4/KANK1/NRP2/PLXND1/BMPR2/SP1/PTK2/PTPRM/PDPK1/ADAM9 22 GO:0031589 cell-substrate adhesion 17/255 363/18722 1.07399613355736e-05 0.00839059479341685 EFNA5/CCDC80/LAMA5/DDR1/JAM3/BCAM/ITGA3/PARVA/DISC1/ITGB4/KANK1/SERPINE1/ADAM15/ITGAV/PTK2/PDPK1/ADAM9 17 GO:0003148 outflow tract septum morphogenesis 5/255 24/18722 1.55003918151776e-05 0.0087561841399674 ISL1/LRP2/PARVA/NRP2/BMPR2 5 GO:0051056 regulation of small GTPase mediated signal transduction 15/255 302/18722 1.80271695167455e-05 0.0087561841399674 PLEKHG4B/PLEKHG1/MET/ARHGAP23/ITGA3/RALGPS1/ARHGAP28/SRGAP3/KANK1/ARHGEF12/ARHGAP24/CHN2/ITGAV/ABCA1/LZTR1 15 GO:0007160 cell-matrix adhesion 13/255 233/18722 1.9613852473527e-05 0.0087561841399674 EFNA5/DDR1/JAM3/BCAM/ITGA3/DISC1/ITGB4/SERPINE1/ADAM15/ITGAV/PTK2/PDPK1/ADAM9 13 GO:0003151 outflow tract morphogenesis 7/255 74/18722 6.62537894710396e-05 0.0204481253922112 ISL1/LRP2/PARVA/TWIST1/NRP2/PLXND1/BMPR2 7 GO:0072337 modified amino acid transport 5/255 32/18722 6.71865302750737e-05 0.0204481253922112 GJA1/LRP2/SLC16A12/SLC19A2/SLC19A1 5 GO:0007411 axon guidance 12/255 227/18722 6.90097002503586e-05 0.0204481253922112 EFNA5/SEMA4G/NOTCH3/NRXN3/LAMA5/GLI3/ISL1/NRP2/PLXND1/BMPR2/PTK2/PTPRM 12 GO:0097485 neuron projection guidance 12/255 228/18722 7.19774013805833e-05 0.0204481253922112 EFNA5/SEMA4G/NOTCH3/NRXN3/LAMA5/GLI3/ISL1/NRP2/PLXND1/BMPR2/PTK2/PTPRM 12 GO:0010634 positive regulation of epithelial cell migration 10/255 176/18722 0.000154462141842987 0.0402245161049445 EPB41L4B/MET/BCAR1/ITGA3/PLPP3/NRP2/BMPR2/SP1/PDPK1/ADAM9 10 GO:0001822 kidney development 13/255 293/18722 0.000201499686400852 0.0484374246155894 FBN1/CXCR2/ENPEP/LAMA5/GLI3/SIX4/LRP2/FRAS1/ADAMTS6/PBX1/ITGA3/PLXND1/CA2 13 GO:0061564 axon development 17/255 467/18722 0.000241058477002088 0.0513214137484364 EFNA5/SEMA4G/NOTCH3/NRXN3/COBL/LAMA5/PAK3/DDR1/GLI3/ISL1/JAM3/DISC1/NRP2/PLXND1/BMPR2/PTK2/PTPRM 17 GO:0042886 amide transport 13/255 301/18722 0.000261755330248632 0.0513214137484364 EFNA5/GJA1/S100A8/ISL1/LRP2/IRS1/PLEKHA8/SLC19A2/SLC19A1/SIRT3/SLC38A5/CA2/ABCA1 13 GO:0072001 renal system development 13/255 302/18722 0.000270272957096711 0.0513214137484364 FBN1/CXCR2/ENPEP/LAMA5/GLI3/SIX4/LRP2/FRAS1/ADAMTS6/PBX1/ITGA3/PLXND1/CA2 13 GO:0036363 transforming growth factor beta activation 3/255 10/18722 0.000279188490791494 0.0513214137484364 ITGB8/LTBP1/ITGAV 3 GO:0035581 sequestering of extracellular ligand from receptor 3/255 11/18722 0.000380025643805303 0.0622209473634036 FBN1/LTBP1/FBN2 3 GO:0007179 transforming growth factor beta receptor signaling pathway 10/255 198/18722 0.000398240585911376 0.0622209473634036 FBN1/PBLD/ITGA3/ITGB8/LTBP1/HTRA4/FBN2/PTK2/PDPK1/ADAM9 10 GO:0010631 epithelial cell migration 14/255 357/18722 0.000408025587700089 0.0622209473634036 EPB41L4B/MET/BCAR1/ITGA3/PLPP3/KANK1/NRP2/PLXND1/BMPR2/SP1/PTK2/PTPRM/PDPK1/ADAM9 14 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/255 131/18722 0.000434493906162985 0.0622209473634036 FBN1/PBLD/LRP2/CRIM1/LTBP1/HTRA4/FBN2/PDPK1 8 GO:0090132 epithelium migration 14/255 360/18722 0.000443481640439553 0.0622209473634036 EPB41L4B/MET/BCAR1/ITGA3/PLPP3/KANK1/NRP2/PLXND1/BMPR2/SP1/PTK2/PTPRM/PDPK1/ADAM9 14 GO:0090130 tissue migration 14/255 365/18722 0.000508421973984542 0.0622209473634036 EPB41L4B/MET/BCAR1/ITGA3/PLPP3/KANK1/NRP2/PLXND1/BMPR2/SP1/PTK2/PTPRM/PDPK1/ADAM9 14 GO:0003279 cardiac septum development 7/255 103/18722 0.00052238444103333 0.0622209473634036 ISL1/LRP2/ADAMTS6/PARVA/NRP2/PLXND1/BMPR2 7 GO:0046580 negative regulation of Ras protein signal transduction 5/255 49/18722 0.000526991374758213 0.0622209473634036 MET/ITGA3/KANK1/ARHGAP24/LZTR1 5 GO:0071692 protein localization to extracellular region 14/255 368/18722 0.000551145639352741 0.0622209473634036 EFNA5/FBN1/GJA1/SNCG/NR1H3/ISL1/IRS1/RAB15/LTBP1/SIRT3/FBN2/ADAM9/ABCA1/DNM1L 14 GO:0048736 appendage development 9/255 172/18722 0.000599095530270431 0.0622209473634036 GLI3/FRAS1/PBX1/TWIST1/ITGB4/INTU/BMPR2/FBN2/PRKAB1 9 GO:0060173 limb development 9/255 172/18722 0.000599095530270431 0.0622209473634036 GLI3/FRAS1/PBX1/TWIST1/ITGB4/INTU/BMPR2/FBN2/PRKAB1 9 GO:0007409 axonogenesis 15/255 418/18722 0.000645130040069237 0.0622209473634036 EFNA5/SEMA4G/NOTCH3/NRXN3/COBL/LAMA5/PAK3/GLI3/ISL1/DISC1/NRP2/PLXND1/BMPR2/PTK2/PTPRM 15 GO:0010745 negative regulation of macrophage derived foam cell differentiation 3/255 13/18722 0.000645548704474413 0.0622209473634036 NR1H3/ITGAV/ABCA1 3 GO:1900115 extracellular regulation of signal transduction 3/255 13/18722 0.000645548704474413 0.0622209473634036 FBN1/LTBP1/FBN2 3 GO:1900116 extracellular negative regulation of signal transduction 3/255 13/18722 0.000645548704474413 0.0622209473634036 FBN1/LTBP1/FBN2 3 GO:0071560 cellular response to transforming growth factor beta stimulus 11/255 250/18722 0.000661790512499239 0.0622209473634036 FBN1/PBLD/COL4A2/ITGA3/ITGB8/LTBP1/HTRA4/FBN2/PTK2/PDPK1/ADAM9 11 GO:0021545 cranial nerve development 5/255 52/18722 0.00069484745882984 0.0622209473634036 GLI3/ISL1/SIX4/ATP8B1/NRP2 5 GO:0010632 regulation of epithelial cell migration 12/255 292/18722 0.000696874610470121 0.0622209473634036 EPB41L4B/MET/BCAR1/ITGA3/PLPP3/NRP2/BMPR2/SP1/PTK2/PTPRM/PDPK1/ADAM9 12 GO:0001655 urogenital system development 13/255 338/18722 0.000781293809029803 0.0678206431449482 FBN1/CXCR2/ENPEP/LAMA5/GLI3/SIX4/LRP2/FRAS1/ADAMTS6/PBX1/ITGA3/PLXND1/CA2 13 GO:0071559 response to transforming growth factor beta 11/255 256/18722 0.000804307215807446 0.0679313526864397 FBN1/PBLD/COL4A2/ITGA3/ITGB8/LTBP1/HTRA4/FBN2/PTK2/PDPK1/ADAM9 11 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 6/255 81/18722 0.000832401363339993 0.0684540594851968 FBN1/PBLD/LTBP1/HTRA4/FBN2/PDPK1 6 GO:0001755 neural crest cell migration 5/255 55/18722 0.000899785392976429 0.0720981885397779 SEMA4G/LAMA5/ISL1/TWIST1/NRP2 5 GO:0051058 negative regulation of small GTPase mediated signal transduction 5/255 56/18722 0.000977165301166186 0.0763410391536083 MET/ITGA3/KANK1/ARHGAP24/LZTR1 5 GO:1904424 regulation of GTP binding 3/255 15/18722 0.00100651432278296 0.076716030699921 MET/ARHGAP28/CLN5 3 GO:0048754 branching morphogenesis of an epithelial tube 8/255 151/18722 0.00110549886036993 0.0822543794918101 LAMA5/MET/DDR1/GLI3/SIX4/PBX1/KDM5B/PLXND1 8 GO:0022604 regulation of cell morphogenesis 12/255 309/18722 0.00113684725025278 0.0826197129544173 EFNA5/SYT1/PAK3/STRIP1/SS18L1/SH3D19/PARVA/FMNL2/KANK1/PLXND1/PTK2/DNM1L 12 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 13/255 355/18722 0.00122060588014076 0.0866907585327247 FBN1/PBLD/LRP2/ITGA3/CRIM1/ITGB8/LTBP1/HTRA4/BMPR2/FBN2/PTK2/PDPK1/ADAM9 13 GO:0034405 response to fluid shear stress 4/255 35/18722 0.00126279730722497 0.0876942574461786 GJA1/ADAM9/CA2/ABCA1 4 GO:0042339 keratan sulfate metabolic process 3/255 17/18722 0.00147426201880419 0.10015366975572 ST3GAL6/B3GNT3/GNS 3 GO:0060562 epithelial tube morphogenesis 12/255 325/18722 0.00174120770148068 0.114024370734154 CXCR2/COBL/LAMA5/MET/DDR1/GLI3/SIX4/LRP2/PBX1/KDM5B/TWIST1/PLXND1 12 GO:0097094 craniofacial suture morphogenesis 3/255 18/18722 0.00175141433447661 0.114024370734154 GLI3/TWIST1/RAB23 3 GO:0010976 positive regulation of neuron projection development 8/255 163/18722 0.00179897651457503 0.114730645062183 COBL/PPP1R9A/PAK3/ITGA3/DISC1/TENM3/KATNB1/DNM1L 8 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 7/255 128/18722 0.00187153142992053 0.116970714370033 FBN1/PBLD/ITGA3/LTBP1/HTRA4/FBN2/PDPK1 7 GO:0010769 regulation of cell morphogenesis involved in differentiation 6/255 96/18722 0.00200815188382762 0.123048522293359 EFNA5/PAK3/SS18L1/KANK1/PTK2/DNM1L 6 GO:0035461 vitamin transmembrane transport 3/255 19/18722 0.002059009840512 0.123230239510402 LRP2/SLC19A2/SLC19A1 3 GO:0071526 semaphorin-plexin signaling pathway 4/255 40/18722 0.00208998486209642 0.123230239510402 SEMA4G/MET/NRP2/PLXND1 4 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 7/255 131/18722 0.00213515856728022 0.123562417087976 FBN1/PBLD/ITGA3/LTBP1/HTRA4/FBN2/PDPK1 7 GO:0010595 positive regulation of endothelial cell migration 7/255 133/18722 0.00232625347119523 0.13040211834857 MET/BCAR1/PLPP3/NRP2/BMPR2/SP1/PDPK1 7 GO:0060411 cardiac septum morphogenesis 5/255 68/18722 0.00233680596080637 0.13040211834857 ISL1/LRP2/PARVA/NRP2/BMPR2 5 GO:0043586 tongue development 3/255 20/18722 0.00239816099573818 0.131478124766348 GLI3/SIX4/INTU 3 GO:0045765 regulation of angiogenesis 12/255 342/18722 0.00265075469255235 0.142820834728036 TLR3/CXCR2/ISL1/COL4A2/EPN2/TWIST1/SERPINE1/PLXND1/ITGB8/SP1/PTPRM/PDPK1 12 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 10/255 256/18722 0.00276864400035165 0.144266560239859 FBN1/PBLD/LRP2/ITGA3/CRIM1/LTBP1/HTRA4/BMPR2/FBN2/PDPK1 10 GO:0010878 cholesterol storage 3/255 21/18722 0.0027699179566053 0.144266560239859 NR1H3/STARD4/ABCA1 3 GO:1901342 regulation of vasculature development 12/255 348/18722 0.0030518822066581 0.152988588029232 TLR3/CXCR2/ISL1/COL4A2/EPN2/TWIST1/SERPINE1/PLXND1/ITGB8/SP1/PTPRM/PDPK1 12 GO:0090287 regulation of cellular response to growth factor stimulus 11/255 304/18722 0.00312529811009115 0.152988588029232 FBN1/PBLD/LRP2/EPN2/ITGA3/CRIM1/LTBP1/HTRA4/BMPR2/FBN2/PDPK1 11 GO:0035024 negative regulation of Rho protein signal transduction 3/255 22/18722 0.00317527040775985 0.152988588029232 MET/ITGA3/KANK1 3 GO:0051180 vitamin transport 4/255 45/18722 0.00323131592263946 0.152988588029232 LRP2/SLC19A2/SLC19A1/SLC52A1 4 GO:0010975 regulation of neuron projection development 14/255 445/18722 0.0032737793920618 0.152988588029232 SEMA4G/LZTS1/COBL/PPP1R9A/PAK3/SS18L1/ITGA3/DISC1/TENM3/KANK1/PLXND1/KATNB1/BMPR2/DNM1L 14 GO:0010810 regulation of cell-substrate adhesion 9/255 221/18722 0.0033842019276243 0.152988588029232 EFNA5/CCDC80/DDR1/ITGA3/DISC1/KANK1/SERPINE1/ADAM15/PTK2 9 GO:0031346 positive regulation of cell projection organization 12/255 353/18722 0.00342257943324498 0.152988588029232 COBL/PPP1R9A/PAK3/SS18L1/ITGA3/DISC1/TENM3/PLXND1/KATNB1/P2RX7/BMPR2/DNM1L 12 GO:0045766 positive regulation of angiogenesis 8/255 181/18722 0.00343797802716761 0.152988588029232 TLR3/CXCR2/ISL1/TWIST1/SERPINE1/ITGB8/SP1/PDPK1 8 GO:1904018 positive regulation of vasculature development 8/255 181/18722 0.00343797802716761 0.152988588029232 TLR3/CXCR2/ISL1/TWIST1/SERPINE1/ITGB8/SP1/PDPK1 8 GO:0061138 morphogenesis of a branching epithelium 8/255 182/18722 0.00355481488535846 0.152988588029232 LAMA5/MET/DDR1/GLI3/SIX4/PBX1/KDM5B/PLXND1 8 GO:0002052 positive regulation of neuroblast proliferation 3/255 23/18722 0.00361514935004804 0.152988588029232 GLI3/DISC1/ZNF335 3 GO:0010888 negative regulation of lipid storage 3/255 23/18722 0.00361514935004804 0.152988588029232 NR1H3/ITGAV/ABCA1 3 GO:0007173 epidermal growth factor receptor signaling pathway 6/255 108/18722 0.00362276976453221 0.152988588029232 GAREM1/BTC/BCAR1/PTK2/GRB7/PDPK1 6 GO:0034446 substrate adhesion-dependent cell spreading 6/255 108/18722 0.00362276976453221 0.152988588029232 EFNA5/LAMA5/PARVA/KANK1/ITGAV/PTK2 6 GO:0050769 positive regulation of neurogenesis 9/255 225/18722 0.00380749760048502 0.158645733353542 PAK3/GLI3/LRP2/SS18L1/DISC1/PLXND1/BMPR2/DNM1L/ZNF335 9 GO:1901653 cellular response to peptide 12/255 359/18722 0.00391461369463317 0.160962734154324 FBN1/GJA1/BCAR1/LDOC1/IRS1/DDX11/KANK1/RAB15/SP1/PTK2/PDPK1/CA2 12 GO:0021675 nerve development 5/255 77/18722 0.00401297144585873 0.162864100887124 GLI3/ISL1/SIX4/ATP8B1/NRP2 5 GO:0033628 regulation of cell adhesion mediated by integrin 4/255 48/18722 0.00408798719594198 0.163781538298958 JAM3/SERPINE1/PTK2/ADAM9 4 GO:0051962 positive regulation of nervous system development 10/255 272/18722 0.00425267015617918 0.16692083491369 PAK3/GLI3/LRP2/SS18L1/DISC1/CLSTN3/PLXND1/BMPR2/DNM1L/ZNF335 10 GO:0051098 regulation of binding 12/255 363/18722 0.00427317337379045 0.16692083491369 MET/ISL1/ARHGAP28/DISC1/TWIST1/DDX11/CLN5/PRMT7/PLXND1/ADAM15/GMNN/SYMPK 12 GO:0070169 positive regulation of biomineral tissue development 4/255 49/18722 0.00440452015782499 0.16992747522473 SLC4A2/P2RX7/BMPR2/FBN2 4 GO:0045732 positive regulation of protein catabolic process 9/255 231/18722 0.00451906333794973 0.172220401598694 GJA1/LRP2/SH3D19/DISC1/CLU/ATG7/HSPBP1/PTK2/ADAM9 9 GO:0010594 regulation of endothelial cell migration 9/255 232/18722 0.00464710925390594 0.172312594233671 MET/BCAR1/PLPP3/NRP2/BMPR2/SP1/PTK2/PTPRM/PDPK1 9 GO:0048592 eye morphogenesis 7/255 151/18722 0.00469775020388589 0.172312594233671 FBN1/GLI3/NAGLU/TWIST1/TENM3/FBN2/PTPRM 7 GO:0110151 positive regulation of biomineralization 4/255 50/18722 0.00473716429288936 0.172312594233671 SLC4A2/P2RX7/BMPR2/FBN2 4 GO:0060560 developmental growth involved in morphogenesis 9/255 234/18722 0.00491166802245591 0.172312594233671 SEMA4G/SYT1/COBL/DDR1/SIX4/KDM5B/DISC1/NRP2/BMPR2 9 GO:0030278 regulation of ossification 6/255 115/18722 0.004925452364097 0.172312594233671 PBX1/TWIST1/INTU/P2RX7/BMPR2/FBN2 6 GO:0014032 neural crest cell development 5/255 81/18722 0.00498114166508543 0.172312594233671 SEMA4G/LAMA5/ISL1/TWIST1/NRP2 5 GO:0043542 endothelial cell migration 10/255 279/18722 0.00507288149944172 0.172312594233671 MET/BCAR1/PLPP3/NRP2/PLXND1/BMPR2/SP1/PTK2/PTPRM/PDPK1 10 GO:0071622 regulation of granulocyte chemotaxis 4/255 51/18722 0.00508628401316804 0.172312594233671 CXCR2/JAM3/PTK2/DNM1L 4 GO:0030326 embryonic limb morphogenesis 6/255 116/18722 0.00513634694422225 0.172312594233671 GLI3/FRAS1/PBX1/TWIST1/INTU/FBN2 6 GO:0035113 embryonic appendage morphogenesis 6/255 116/18722 0.00513634694422225 0.172312594233671 GLI3/FRAS1/PBX1/TWIST1/INTU/FBN2 6 GO:0060037 pharyngeal system development 3/255 26/18722 0.0051504112624988 0.172312594233671 ISL1/SIX4/BMPR2 3 GO:0034329 cell junction assembly 13/255 420/18722 0.00518316283454884 0.172312594233671 EFNA5/GJA1/CLDN19/PPP1R9A/JAM3/SIX4/CLSTN3/DST/ITGB4/PLXND1/CTNND1/PTK2/PDPK1 13 GO:0051235 maintenance of location 11/255 326/18722 0.00526561995172707 0.173211182622601 FBN1/GJA1/NR1H3/S100A8/KDELR3/STARD4/LTBP1/ITGAV/FBN2/PDPK1/ABCA1 11 GO:0042060 wound healing 13/255 422/18722 0.00538867482439926 0.17541259194008 GJA1/CLDN19/EPB41L4B/S100A8/DDR1/GLI3/PLPP3/DST/KANK1/SERPINE1/ARHGAP24/F5/PTK2 13 GO:0001763 morphogenesis of a branching structure 8/255 196/18722 0.00553570778780955 0.17834110141139 LAMA5/MET/DDR1/GLI3/SIX4/PBX1/KDM5B/PLXND1 8 GO:0006835 dicarboxylic acid transport 5/255 84/18722 0.00580833709221235 0.185214830746567 GJA1/LRP2/SLC26A2/SLC19A2/SLC19A1 5 GO:0001656 metanephros development 5/255 85/18722 0.00610434119489154 0.187231193090654 FBN1/CXCR2/GLI3/SIX4/FRAS1 5 GO:0060021 roof of mouth development 5/255 85/18722 0.00610434119489154 0.187231193090654 GLI3/FRAS1/TWIST1/ITGB8/INTU 5 GO:0072348 sulfur compound transport 4/255 54/18722 0.00623603950779622 0.187231193090654 GJA1/SLC13A4/SLC26A2/SLC19A2 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/255 54/18722 0.00623603950779622 0.187231193090654 GLI3/LRP2/DISC1/ZNF335 4 GO:0001704 formation of primary germ layer 6/255 121/18722 0.00629141221813524 0.187231193090654 GJA1/COL4A2/ITGA3/ITGB4/BMPR2/ITGAV 6 GO:0038127 ERBB signaling pathway 6/255 121/18722 0.00629141221813524 0.187231193090654 GAREM1/BTC/BCAR1/PTK2/GRB7/PDPK1 6 GO:0045671 negative regulation of osteoclast differentiation 3/255 28/18722 0.00636113522565807 0.187231193090654 TLR3/FBN1/PIAS3 3 GO:0014031 mesenchymal cell development 5/255 86/18722 0.00641079605142398 0.187231193090654 SEMA4G/LAMA5/ISL1/TWIST1/NRP2 5 GO:0048864 stem cell development 5/255 86/18722 0.00641079605142398 0.187231193090654 SEMA4G/LAMA5/ISL1/TWIST1/NRP2 5 GO:0098656 anion transmembrane transport 9/255 245/18722 0.00658239831780957 0.1900095250013 GJA1/LRP2/SLC16A12/GABRE/SLC4A2/SLC13A4/SLC26A2/SLC19A1/SLC38A5 9 GO:0003205 cardiac chamber development 7/255 161/18722 0.00662753223204533 0.1900095250013 ISL1/LRP2/ADAMTS6/PARVA/NRP2/PLXND1/BMPR2 7 GO:0003007 heart morphogenesis 9/255 246/18722 0.00675356007823658 0.19186250222263 ISL1/LRP2/PARVA/TWIST1/NRP2/PLXND1/ADAM15/BMPR2/PTK2 9 GO:0021602 cranial nerve morphogenesis 3/255 29/18722 0.00702465279769943 0.194388503902919 GLI3/ATP8B1/NRP2 3 GO:0034311 diol metabolic process 3/255 29/18722 0.00702465279769943 0.194388503902919 ASAH2B/SPR/PLPP3 3 GO:0010232 vascular transport 5/255 88/18722 0.00705580315604965 0.194388503902919 GJA1/LRP2/SLC16A12/SLC19A1/SLC38A5 5 GO:0001658 branching involved in ureteric bud morphogenesis 4/255 56/18722 0.00709129262237848 0.194388503902919 LAMA5/GLI3/SIX4/PBX1 4 GO:0003183 mitral valve morphogenesis 2/255 10/18722 0.00773715215559146 0.202824284230365 TWIST1/BMPR2 2 GO:0021562 vestibulocochlear nerve development 2/255 10/18722 0.00773715215559146 0.202824284230365 ATP8B1/NRP2 2 GO:0045843 negative regulation of striated muscle tissue development 2/255 10/18722 0.00773715215559146 0.202824284230365 TWIST1/USP19 2 GO:2001225 regulation of chloride transport 2/255 10/18722 0.00773715215559146 0.202824284230365 ATP8B1/GABRE 2 GO:0042475 odontogenesis of dentin-containing tooth 5/255 90/18722 0.00774483288445388 0.202824284230365 LAMA5/GLI3/SLC4A2/SERPINE1/CA2 5 GO:1902904 negative regulation of supramolecular fiber organization 7/255 166/18722 0.00778845251444602 0.202824284230365 KANK4/PPP1R9A/MET/ARHGAP28/CLU/KANK1/KATNB1 7 GO:0048511 rhythmic process 10/255 298/18722 0.00793335728655852 0.204890425789218 GPR157/NR1H3/C3orf70/BHLHE41/NAGLU/KDM5B/TWIST1/ATG7/SP1/DNM1L 10 GO:0007405 neuroblast proliferation 4/255 58/18722 0.00802059883416985 0.205445666858859 TEAD3/GLI3/DISC1/ZNF335 4 GO:0014033 neural crest cell differentiation 5/255 91/18722 0.00810630965474761 0.205952989195823 SEMA4G/LAMA5/ISL1/TWIST1/NRP2 5 GO:0001952 regulation of cell-matrix adhesion 6/255 128/18722 0.00821134471332509 0.206939130880169 EFNA5/DDR1/DISC1/SERPINE1/ADAM15/PTK2 6 GO:1900027 regulation of ruffle assembly 3/255 31/18722 0.00847083500716121 0.207415654306438 COBL/KANK1/ARHGAP24 3 GO:0090303 positive regulation of wound healing 4/255 59/18722 0.00851380152066231 0.207415654306438 PLPP3/KANK1/SERPINE1/PTK2 4 GO:0090596 sensory organ morphogenesis 9/255 256/18722 0.00865919739740574 0.207415654306438 FBN1/GLI3/SIX4/NAGLU/TWIST1/TENM3/INTU/FBN2/PTPRM 9 GO:0042476 odontogenesis 6/255 130/18722 0.00882963243686895 0.207415654306438 LAMA5/GLI3/SLC4A2/TWIST1/SERPINE1/CA2 6 GO:0045185 maintenance of protein location 5/255 93/18722 0.00886407784960883 0.207415654306438 FBN1/GJA1/KDELR3/LTBP1/FBN2 5 GO:0060993 kidney morphogenesis 5/255 93/18722 0.00886407784960883 0.207415654306438 LAMA5/GLI3/SIX4/FRAS1/PBX1 5 GO:0008156 negative regulation of DNA replication 3/255 32/18722 0.00925449741631149 0.207415654306438 CDAN1/ATG7/GMNN 3 GO:0010743 regulation of macrophage derived foam cell differentiation 3/255 32/18722 0.00925449741631149 0.207415654306438 NR1H3/ITGAV/ABCA1 3 GO:0051497 negative regulation of stress fiber assembly 3/255 32/18722 0.00925449741631149 0.207415654306438 PPP1R9A/MET/ARHGAP28 3 GO:0090022 regulation of neutrophil chemotaxis 3/255 32/18722 0.00925449741631149 0.207415654306438 CXCR2/JAM3/DNM1L 3 GO:0003139 secondary heart field specification 2/255 11/18722 0.00937206915821062 0.207415654306438 ISL1/LRP2 2 GO:0003174 mitral valve development 2/255 11/18722 0.00937206915821062 0.207415654306438 TWIST1/BMPR2 2 GO:0010887 negative regulation of cholesterol storage 2/255 11/18722 0.00937206915821062 0.207415654306438 NR1H3/ABCA1 2 GO:0032000 positive regulation of fatty acid beta-oxidation 2/255 11/18722 0.00937206915821062 0.207415654306438 IRS1/TWIST1 2 GO:0048635 negative regulation of muscle organ development 2/255 11/18722 0.00937206915821062 0.207415654306438 TWIST1/USP19 2 GO:1901862 negative regulation of muscle tissue development 2/255 11/18722 0.00937206915821062 0.207415654306438 TWIST1/USP19 2 GO:0045667 regulation of osteoblast differentiation 6/255 132/18722 0.00948057869873546 0.207415654306438 GLI3/CRIM1/TWIST1/BMPR2/FBN2/PTK2 6 GO:0015711 organic anion transport 11/255 354/18722 0.00950646416048029 0.207415654306438 GJA1/LRP2/ATP8B1/SLC16A12/SLC4A2/SLC26A2/PLEKHA8/SLC19A2/SLC19A1/SLC38A5/SLC52A1 11 GO:0060998 regulation of dendritic spine development 4/255 61/18722 0.00955879621268693 0.207415654306438 PPP1R9A/PAK3/DISC1/DNM1L 4 GO:0051099 positive regulation of binding 7/255 173/18722 0.00965750404402684 0.207415654306438 MET/ISL1/TWIST1/DDX11/CLN5/PLXND1/GMNN 7 GO:0007044 cell-substrate junction assembly 5/255 95/18722 0.00966943039111354 0.207415654306438 EFNA5/DST/ITGB4/PTK2/PDPK1 5 GO:0048048 embryonic eye morphogenesis 3/255 33/18722 0.010079133335693 0.207415654306438 FBN1/TWIST1/FBN2 3 GO:0048333 mesodermal cell differentiation 3/255 33/18722 0.010079133335693 0.207415654306438 GJA1/ITGA3/ITGB4 3 GO:1902692 regulation of neuroblast proliferation 3/255 33/18722 0.010079133335693 0.207415654306438 GLI3/DISC1/ZNF335 3 GO:0030510 regulation of BMP signaling pathway 5/255 96/18722 0.0100903797596457 0.207415654306438 FBN1/LRP2/ITGA3/CRIM1/BMPR2 5 GO:0048488 synaptic vesicle endocytosis 4/255 62/18722 0.0101111600436588 0.207415654306438 SYT1/SNCG/SYT8/DNM1L 4 GO:0060675 ureteric bud morphogenesis 4/255 62/18722 0.0101111600436588 0.207415654306438 LAMA5/GLI3/SIX4/PBX1 4 GO:0140238 presynaptic endocytosis 4/255 62/18722 0.0101111600436588 0.207415654306438 SYT1/SNCG/SYT8/DNM1L 4 GO:0061041 regulation of wound healing 6/255 134/18722 0.0101650766758273 0.207415654306438 GJA1/CLDN19/PLPP3/KANK1/SERPINE1/PTK2 6 GO:0007163 establishment or maintenance of cell polarity 8/255 218/18722 0.0102214434442213 0.207415654306438 GJA1/JAM3/PARD3B/WEE1/PARVA/DST/KANK1/PTK2 8 GO:0001503 ossification 12/255 408/18722 0.0104144344834746 0.20946925950821 IGSF10/GLI3/PBX1/CRIM1/SLC26A2/TWIST1/INTU/P2RX7/BMPR2/FBN2/PTK2/RRBP1 12 GO:0009306 protein secretion 11/255 359/18722 0.0104832042287578 0.20946925950821 EFNA5/GJA1/SNCG/NR1H3/ISL1/IRS1/RAB15/SIRT3/ADAM9/ABCA1/DNM1L 11 GO:0070167 regulation of biomineral tissue development 5/255 97/18722 0.0105237355976924 0.20946925950821 SLC4A2/TWIST1/P2RX7/BMPR2/FBN2 5 GO:0072171 mesonephric tubule morphogenesis 4/255 63/18722 0.0106838024014534 0.210052794803137 LAMA5/GLI3/SIX4/PBX1 4 GO:0035592 establishment of protein localization to extracellular region 11/255 360/18722 0.0106874861995836 0.210052794803137 EFNA5/GJA1/SNCG/NR1H3/ISL1/IRS1/RAB15/SIRT3/ADAM9/ABCA1/DNM1L 11 GO:0033629 negative regulation of cell adhesion mediated by integrin 2/255 12/18722 0.0111461607534101 0.211101529420647 JAM3/SERPINE1 2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 2/255 12/18722 0.0111461607534101 0.211101529420647 DDR1/COL4A2 2 GO:0045117 azole transmembrane transport 2/255 12/18722 0.0111461607534101 0.211101529420647 SLC19A2/SLC38A5 2 GO:0051549 positive regulation of keratinocyte migration 2/255 12/18722 0.0111461607534101 0.211101529420647 EPB41L4B/ADAM9 2 GO:0060019 radial glial cell differentiation 2/255 12/18722 0.0111461607534101 0.211101529420647 GPR157/GLI3 2 GO:0061517 macrophage proliferation 2/255 12/18722 0.0111461607534101 0.211101529420647 CLU/PTK2 2 GO:0045670 regulation of osteoclast differentiation 4/255 64/18722 0.0112769885608615 0.211450659014713 TLR3/FBN1/PIAS3/CA2 4 GO:0110149 regulation of biomineralization 5/255 99/18722 0.0114283261066971 0.211450659014713 SLC4A2/TWIST1/P2RX7/BMPR2/FBN2 5 GO:0050767 regulation of neurogenesis 11/255 364/18722 0.0115353449300395 0.211450659014713 SEMA4G/PAK3/GLI3/LRP2/SS18L1/BHLHE41/DISC1/PLXND1/BMPR2/DNM1L/ZNF335 11 GO:0002274 myeloid leukocyte activation 8/255 223/18722 0.0116068524012537 0.211450659014713 TLR3/CXCR2/NR1H3/SHPK/CLU/ITGB8/PDPK1/ADAM9 8 GO:0050920 regulation of chemotaxis 8/255 223/18722 0.0116068524012537 0.211450659014713 SEMA4G/CXCR2/MET/JAM3/SERPINE1/BMPR2/PTK2/DNM1L 8 GO:0035107 appendage morphogenesis 6/255 138/18722 0.0116382442721698 0.211450659014713 GLI3/FRAS1/PBX1/TWIST1/INTU/FBN2 6 GO:0035108 limb morphogenesis 6/255 138/18722 0.0116382442721698 0.211450659014713 GLI3/FRAS1/PBX1/TWIST1/INTU/FBN2 6 GO:0032232 negative regulation of actin filament bundle assembly 3/255 35/18722 0.0118528540689766 0.213719190338488 PPP1R9A/MET/ARHGAP28 3 GO:0060840 artery development 5/255 100/18722 0.011899884518047 0.213719190338488 GLI3/LRP2/ADAMTS6/PLXND1/BMPR2 5 GO:0033674 positive regulation of kinase activity 13/255 467/18722 0.0120110213206667 0.214482523583334 EFNA5/TLR3/BTC/PPP1R9A/MET/DDR1/IRS1/CLU/BMPR2/PTK2/ACSL1/PDPK1/ADAM9 13 GO:0150115 cell-substrate junction organization 5/255 101/18722 0.0123844967561099 0.21943221409976 EFNA5/DST/ITGB4/PTK2/PDPK1 5 GO:0015748 organophosphate ester transport 6/255 140/18722 0.0124286406066104 0.21943221409976 GJA1/ATP8B1/PLEKHA8/SLC19A1/P2RX7/ABCA1 6 GO:0010092 specification of animal organ identity 3/255 36/18722 0.0128026037559388 0.220529779461584 GLI3/ISL1/LRP2 3 GO:0014046 dopamine secretion 3/255 36/18722 0.0128026037559388 0.220529779461584 SYT1/SNCG/SYT8 3 GO:0014059 regulation of dopamine secretion 3/255 36/18722 0.0128026037559388 0.220529779461584 SYT1/SNCG/SYT8 3 GO:0050921 positive regulation of chemotaxis 6/255 141/18722 0.0128376628198656 0.220529779461584 CXCR2/MET/SERPINE1/BMPR2/PTK2/DNM1L 6 GO:0010635 regulation of mitochondrial fusion 2/255 13/18722 0.0130553629441257 0.220529779461584 PLD6/DNM1L 2 GO:0048012 hepatocyte growth factor receptor signaling pathway 2/255 13/18722 0.0130553629441257 0.220529779461584 MET/BCAR1 2 GO:0098814 spontaneous synaptic transmission 2/255 13/18722 0.0130553629441257 0.220529779461584 SYT1/PPP1R9A 2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 2/255 13/18722 0.0130553629441257 0.220529779461584 NRP2/PLXND1 2 GO:0048814 regulation of dendrite morphogenesis 4/255 67/18722 0.0131823365221566 0.221477428127631 LZTS1/PAK3/SS18L1/DNM1L 4 GO:0072006 nephron development 6/255 142/18722 0.013256039880038 0.221524730615608 ENPEP/LAMA5/GLI3/SIX4/PBX1/ITGA3 6 GO:0050773 regulation of dendrite development 5/255 103/18722 0.0133935026070462 0.22211830420258 LZTS1/COBL/PAK3/SS18L1/DNM1L 5 GO:0030010 establishment of cell polarity 6/255 143/18722 0.0136838746621139 0.22211830420258 GJA1/JAM3/PARD3B/WEE1/KANK1/PTK2 6 GO:0048608 reproductive structure development 12/255 424/18722 0.0137689528954367 0.22211830420258 TLR3/GJA1/GLI3/SIX4/LRP2/KDM5B/FANCA/IDH1/ITGB8/ADAM15/BMPR2/PTK2 12 GO:0048846 axon extension involved in axon guidance 3/255 37/18722 0.0137946592839224 0.22211830420258 SEMA4G/NRP2/BMPR2 3 GO:0050775 positive regulation of dendrite morphogenesis 3/255 37/18722 0.0137946592839224 0.22211830420258 PAK3/SS18L1/DNM1L 3 GO:1902284 neuron projection extension involved in neuron projection guidance 3/255 37/18722 0.0137946592839224 0.22211830420258 SEMA4G/NRP2/BMPR2 3 GO:0010812 negative regulation of cell-substrate adhesion 4/255 68/18722 0.013860182182241 0.22211830420258 EFNA5/KANK1/SERPINE1/ADAM15 4 GO:1904888 cranial skeletal system development 4/255 68/18722 0.013860182182241 0.22211830420258 GLI3/SIX4/TWIST1/RAB23 4 GO:0061458 reproductive system development 12/255 427/18722 0.0144806148563877 0.228418234921416 TLR3/GJA1/GLI3/SIX4/LRP2/KDM5B/FANCA/IDH1/ITGB8/ADAM15/BMPR2/PTK2 12 GO:0010742 macrophage derived foam cell differentiation 3/255 38/18722 0.0148292595411965 0.228418234921416 NR1H3/ITGAV/ABCA1 3 GO:0090077 foam cell differentiation 3/255 38/18722 0.0148292595411965 0.228418234921416 NR1H3/ITGAV/ABCA1 3 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 2/255 14/18722 0.0150956958641732 0.228418234921416 EFNA5/KANK1 2 GO:0034616 response to laminar fluid shear stress 2/255 14/18722 0.0150956958641732 0.228418234921416 ADAM9/ABCA1 2 GO:0035437 maintenance of protein localization in endoplasmic reticulum 2/255 14/18722 0.0150956958641732 0.228418234921416 GJA1/KDELR3 2 GO:0035563 positive regulation of chromatin binding 2/255 14/18722 0.0150956958641732 0.228418234921416 DDX11/GMNN 2 GO:0035672 oligopeptide transmembrane transport 2/255 14/18722 0.0150956958641732 0.228418234921416 GJA1/CA2 2 GO:0036151 phosphatidylcholine acyl-chain remodeling 2/255 14/18722 0.0150956958641732 0.228418234921416 NR1H3/PLB1 2 GO:0051547 regulation of keratinocyte migration 2/255 14/18722 0.0150956958641732 0.228418234921416 EPB41L4B/ADAM9 2 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 2/255 14/18722 0.0150956958641732 0.228418234921416 EFNA5/KANK1 2 GO:0046578 regulation of Ras protein signal transduction 7/255 189/18722 0.0151304238811946 0.228418234921416 MET/ITGA3/RALGPS1/KANK1/ARHGAP24/ABCA1/LZTR1 7 GO:0016049 cell growth 13/255 482/18722 0.0152507195048681 0.229127396407274 SEMA4G/SYT1/GJA1/COBL/S100A8/DDR1/BCAR1/N6AMT1/DISC1/CLSTN3/NRP2/ADAM15/BMPR2 13 GO:0030041 actin filament polymerization 7/255 190/18722 0.0155330756686741 0.231792001710373 KANK4/COBL/PPP1R9A/PAK3/GAS7/ARHGAP28/KANK1 7 GO:0003002 regionalization 10/255 331/18722 0.0156764210676013 0.231792001710373 COBL/GLI3/ISL1/LRP2/BHLHE41/PBX1/NRP2/INTU/BMPR2/PLD6 10 GO:0048880 sensory system development 11/255 381/18722 0.0157247693960317 0.231792001710373 FBN1/GLI3/ISL1/NAGLU/PBX1/KDM5B/TWIST1/TENM3/BMPR2/FBN2/PTPRM 11 GO:0050678 regulation of epithelial cell proliferation 11/255 381/18722 0.0157247693960317 0.231792001710373 GJA1/ISL1/SIX4/KDM5B/TWIST1/NRP2/INTU/BMPR2/SP1/PTPRM/PDPK1 11 GO:0045923 positive regulation of fatty acid metabolic process 3/255 39/18722 0.0159066082141534 0.232921923949151 NR1H3/IRS1/TWIST1 3 GO:0044272 sulfur compound biosynthetic process 6/255 148/18722 0.0159684413903445 0.232921923949151 CHST3/ST3GAL6/B3GNT3/SLC26A2/SP1/ACSL1 6 GO:0072078 nephron tubule morphogenesis 4/255 71/18722 0.0160250283677016 0.232921923949151 LAMA5/GLI3/SIX4/PBX1 4 GO:0015850 organic hydroxy compound transport 9/255 284/18722 0.0161737572152786 0.233995330082155 SYT1/SNCG/NR1H3/ATP8B1/KDM5B/CLU/STARD4/SYT8/ABCA1 9 GO:0045834 positive regulation of lipid metabolic process 6/255 149/18722 0.0164551232144502 0.236612695383173 NR1H3/IRS1/TWIST1/STARD4/SIRT3/PTK2 6 GO:0007565 female pregnancy 7/255 193/18722 0.0167867076507569 0.236612695383173 TEAD3/GJA1/DDR1/ITGA3/ITGB4/SLC19A1/BMPR2 7 GO:0001707 mesoderm formation 4/255 72/18722 0.0167910991762923 0.236612695383173 GJA1/ITGA3/ITGB4/BMPR2 4 GO:1903036 positive regulation of response to wounding 4/255 72/18722 0.0167910991762923 0.236612695383173 PLPP3/KANK1/SERPINE1/PTK2 4 GO:0030501 positive regulation of bone mineralization 3/255 40/18722 0.0170268749724282 0.236612695383173 P2RX7/BMPR2/FBN2 3 GO:0010763 positive regulation of fibroblast migration 2/255 15/18722 0.0172632622551563 0.236612695383173 PAK3/PTK2 2 GO:0018146 keratan sulfate biosynthetic process 2/255 15/18722 0.0172632622551563 0.236612695383173 ST3GAL6/B3GNT3 2 GO:0043584 nose development 2/255 15/18722 0.0172632622551563 0.236612695383173 GLI3/SIX4 2 GO:0045176 apical protein localization 2/255 15/18722 0.0172632622551563 0.236612695383173 JAM3/ATP8B1 2 GO:0046321 positive regulation of fatty acid oxidation 2/255 15/18722 0.0172632622551563 0.236612695383173 IRS1/TWIST1 2 GO:0060413 atrial septum morphogenesis 2/255 15/18722 0.0172632622551563 0.236612695383173 ISL1/BMPR2 2 GO:2000104 negative regulation of DNA-dependent DNA replication 2/255 15/18722 0.0172632622551563 0.236612695383173 ATG7/GMNN 2 GO:0007265 Ras protein signal transduction 10/255 337/18722 0.0175411047120624 0.238854878033977 MET/ITGA3/RALGPS1/RAB9B/KANK1/ARHGEF12/RAB15/ARHGAP24/ABCA1/LZTR1 10 GO:0072088 nephron epithelium morphogenesis 4/255 73/18722 0.0175797190233007 0.238854878033977 LAMA5/GLI3/SIX4/PBX1 4 GO:0031032 actomyosin structure organization 7/255 196/18722 0.0181103174280197 0.242909713717121 EPB41L4B/PPP1R9A/MET/TNNT3/SIX4/FRMD6/ARHGAP28 7 GO:0071634 regulation of transforming growth factor beta production 3/255 41/18722 0.0181901966248495 0.242909713717121 ITGB8/LTBP1/ITGAV 3 GO:1902622 regulation of neutrophil migration 3/255 41/18722 0.0181901966248495 0.242909713717121 CXCR2/JAM3/DNM1L 3 GO:0006790 sulfur compound metabolic process 10/255 339/18722 0.0181976770090974 0.242909713717121 CHST3/ST3GAL6/B3GNT3/SLC26A2/IDH1/SLC19A2/SP1/ACSL1/GNS/TPST2 10 GO:0071375 cellular response to peptide hormone stimulus 9/255 290/18722 0.0182668104715275 0.242909713717121 FBN1/BCAR1/IRS1/KANK1/RAB15/SP1/PTK2/PDPK1/CA2 9 GO:0048332 mesoderm morphogenesis 4/255 74/18722 0.0183910678049313 0.243525791908518 GJA1/ITGA3/ITGB4/BMPR2 4 GO:0051960 regulation of nervous system development 12/255 443/18722 0.0187597011494364 0.24735892865818 SEMA4G/PAK3/GLI3/LRP2/SS18L1/BHLHE41/DISC1/CLSTN3/PLXND1/BMPR2/DNM1L/ZNF335 12 GO:0036465 synaptic vesicle recycling 4/255 75/18722 0.0192253168288334 0.248402514850092 SYT1/SNCG/SYT8/DNM1L 4 GO:0061333 renal tubule morphogenesis 4/255 75/18722 0.0192253168288334 0.248402514850092 LAMA5/GLI3/SIX4/PBX1 4 GO:0060999 positive regulation of dendritic spine development 3/255 42/18722 0.0193966782468338 0.248402514850092 PPP1R9A/PAK3/DNM1L 3 GO:0006857 oligopeptide transport 2/255 16/18722 0.0195542459689992 0.248402514850092 GJA1/CA2 2 GO:0033631 cell-cell adhesion mediated by integrin 2/255 16/18722 0.0195542459689992 0.248402514850092 PLPP3/ADAM9 2 GO:0048311 mitochondrion distribution 2/255 16/18722 0.0195542459689992 0.248402514850092 CLUH/DNM1L 2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 2/255 16/18722 0.0195542459689992 0.248402514850092 SH3D19/ADAM9 2 GO:0061548 ganglion development 2/255 16/18722 0.0195542459689992 0.248402514850092 SIX4/NRP2 2 GO:0061684 chaperone-mediated autophagy 2/255 16/18722 0.0195542459689992 0.248402514850092 CLU/ATG7 2 GO:0072028 nephron morphogenesis 4/255 76/18722 0.0200826288318648 0.254081842508411 LAMA5/GLI3/SIX4/PBX1 4 GO:0051258 protein polymerization 9/255 296/18722 0.0205506010428535 0.256031675097134 KANK4/COBL/PPP1R9A/PAK3/MET/GAS7/ARHGAP28/KANK1/DNM1L 9 GO:0006509 membrane protein ectodomain proteolysis 3/255 43/18722 0.0206463942798329 0.256031675097134 SH3D19/PSEN2/ADAM9 3 GO:0032365 intracellular lipid transport 3/255 43/18722 0.0206463942798329 0.256031675097134 STARD4/PLEKHA8/ABCA1 3 GO:0060443 mammary gland morphogenesis 3/255 43/18722 0.0206463942798329 0.256031675097134 DDR1/GLI3/KDM5B 3 GO:0071604 transforming growth factor beta production 3/255 43/18722 0.0206463942798329 0.256031675097134 ITGB8/LTBP1/ITGAV 3 GO:0090087 regulation of peptide transport 7/255 202/18722 0.0209747795386859 0.259075834222899 EFNA5/GJA1/S100A8/ISL1/IRS1/SIRT3/CA2 7 GO:0010720 positive regulation of cell development 9/255 298/18722 0.0213557693917504 0.260367970037205 PAK3/GLI3/LRP2/SS18L1/DISC1/PLXND1/BMPR2/DNM1L/ZNF335 9 GO:0030500 regulation of bone mineralization 4/255 78/18722 0.0218670500160363 0.260367970037205 TWIST1/P2RX7/BMPR2/FBN2 4 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 3/255 44/18722 0.0219393896034234 0.260367970037205 TLR3/NR1H3/ZCCHC3 3 GO:0097178 ruffle assembly 3/255 44/18722 0.0219393896034234 0.260367970037205 COBL/KANK1/ARHGAP24 3 GO:0001780 neutrophil homeostasis 2/255 17/18722 0.0219649104956919 0.260367970037205 CXCR2/JAM3 2 GO:0021513 spinal cord dorsal/ventral patterning 2/255 17/18722 0.0219649104956919 0.260367970037205 GLI3/INTU 2 GO:0038065 collagen-activated signaling pathway 2/255 17/18722 0.0219649104956919 0.260367970037205 DDR1/COL4A2 2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 2/255 17/18722 0.0219649104956919 0.260367970037205 SYT1/SYT8 2 GO:0061450 trophoblast cell migration 2/255 17/18722 0.0219649104956919 0.260367970037205 GJA1/ITGB4 2 GO:1902358 sulfate transmembrane transport 2/255 17/18722 0.0219649104956919 0.260367970037205 SLC13A4/SLC26A2 2 GO:1901888 regulation of cell junction assembly 7/255 204/18722 0.0219958861087431 0.260367970037205 EFNA5/GJA1/CLDN19/PPP1R9A/SIX4/CLSTN3/PTK2 7 GO:0022612 gland morphogenesis 5/255 118/18722 0.0227602822723132 0.267390534214206 LAMA5/DDR1/GLI3/KDM5B/PLXND1 5 GO:0030203 glycosaminoglycan metabolic process 5/255 118/18722 0.0227602822723132 0.267390534214206 CHST3/ST3GAL6/B3GNT3/NAGLU/GNS 5 GO:0003197 endocardial cushion development 3/255 45/18722 0.0232756805806222 0.270395917525816 ISL1/TWIST1/BMPR2 3 GO:0035272 exocrine system development 3/255 45/18722 0.0232756805806222 0.270395917525816 LAMA5/PLXND1/IGSF3 3 GO:0060119 inner ear receptor cell development 3/255 45/18722 0.0232756805806222 0.270395917525816 TMC1/ATP8B1/NAGLU 3 GO:0021953 central nervous system neuron differentiation 6/255 162/18722 0.0237382445111867 0.272253269401482 GLI3/ISL1/TTLL1/DISC1/NRP2/ZNF335 6 GO:0051494 negative regulation of cytoskeleton organization 6/255 162/18722 0.0237382445111867 0.272253269401482 KANK4/PPP1R9A/MET/ARHGAP28/KANK1/KATNB1 6 GO:0048593 camera-type eye morphogenesis 5/255 120/18722 0.0242627757583511 0.272253269401482 GLI3/NAGLU/TWIST1/TENM3/PTPRM 5 GO:0001956 positive regulation of neurotransmitter secretion 2/255 18/18722 0.0244915975158438 0.272253269401482 SYT1/DNM1L 2 GO:0002544 chronic inflammatory response 2/255 18/18722 0.0244915975158438 0.272253269401482 GJA1/S100A8 2 GO:0003128 heart field specification 2/255 18/18722 0.0244915975158438 0.272253269401482 ISL1/LRP2 2 GO:0008272 sulfate transport 2/255 18/18722 0.0244915975158438 0.272253269401482 SLC13A4/SLC26A2 2 GO:0021511 spinal cord patterning 2/255 18/18722 0.0244915975158438 0.272253269401482 GLI3/INTU 2 GO:0051782 negative regulation of cell division 2/255 18/18722 0.0244915975158438 0.272253269401482 SUSD2/INTU 2 GO:0071360 cellular response to exogenous dsRNA 2/255 18/18722 0.0244915975158438 0.272253269401482 TLR3/ZCCHC3 2 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 2/255 18/18722 0.0244915975158438 0.272253269401482 ISL1/BMPR2 2 GO:0048701 embryonic cranial skeleton morphogenesis 3/255 46/18722 0.0246552560769982 0.272253269401482 GLI3/SIX4/TWIST1 3 GO:0050919 negative chemotaxis 3/255 46/18722 0.0246552560769982 0.272253269401482 SEMA4G/NRP2/ITGAV 3 GO:0060976 coronary vasculature development 3/255 46/18722 0.0246552560769982 0.272253269401482 LRP2/ADAMTS6/PLXND1 3 GO:0003206 cardiac chamber morphogenesis 5/255 121/18722 0.0250374034971536 0.274532933082824 ISL1/LRP2/PARVA/NRP2/BMPR2 5 GO:0048706 embryonic skeletal system development 5/255 121/18722 0.0250374034971536 0.274532933082824 GLI3/SIX4/PBX1/TWIST1/KIAA1217 5 GO:0023061 signal release 12/255 463/18722 0.025364571917384 0.277147857488899 EFNA5/SYT1/GJA1/SNCG/PPP1R9A/ISL1/KDM5B/IRS1/SIRT3/SYT8/ABCA1/DNM1L 12 GO:0002688 regulation of leukocyte chemotaxis 5/255 122/18722 0.0258277471969943 0.279089024551994 CXCR2/JAM3/SERPINE1/PTK2/DNM1L 5 GO:0050807 regulation of synapse organization 7/255 211/18722 0.025840545918429 0.279089024551994 PPP1R9A/PAK3/SIX4/DISC1/CLSTN3/NRP2/DNM1L 7 GO:0010761 fibroblast migration 3/255 47/18722 0.0260780784541383 0.279089024551994 PAK3/TMEM201/PTK2 3 GO:0045332 phospholipid translocation 3/255 47/18722 0.0260780784541383 0.279089024551994 ATP8B1/P2RX7/ABCA1 3 GO:0048512 circadian behavior 3/255 47/18722 0.0260780784541383 0.279089024551994 GPR157/C3orf70/NAGLU 3 GO:0061001 regulation of dendritic spine morphogenesis 3/255 47/18722 0.0260780784541383 0.279089024551994 PPP1R9A/PAK3/DNM1L 3 GO:0060326 cell chemotaxis 9/255 310/18722 0.0266697076516334 0.280740122906121 CXCR2/S100A8/MET/JAM3/BCAR1/PARVA/SERPINE1/PTK2/DNM1L 9 GO:0001558 regulation of cell growth 11/255 414/18722 0.0269859166333238 0.280740122906121 SEMA4G/SYT1/GJA1/S100A8/DDR1/BCAR1/N6AMT1/DISC1/CLSTN3/ADAM15/BMPR2 11 GO:0043583 ear development 7/255 213/18722 0.0270183293646344 0.280740122906121 TMC1/DDR1/GLI3/SIX4/ATP8B1/NAGLU/TWIST1 7 GO:1903034 regulation of response to wounding 6/255 167/18722 0.0270363630722599 0.280740122906121 GJA1/CLDN19/PLPP3/KANK1/SERPINE1/PTK2 6 GO:0002523 leukocyte migration involved in inflammatory response 2/255 19/18722 0.0271307254776475 0.280740122906121 S100A8/JAM3 2 GO:0006670 sphingosine metabolic process 2/255 19/18722 0.0271307254776475 0.280740122906121 ASAH2B/PLPP3 2 GO:0010885 regulation of cholesterol storage 2/255 19/18722 0.0271307254776475 0.280740122906121 NR1H3/ABCA1 2 GO:0031290 retinal ganglion cell axon guidance 2/255 19/18722 0.0271307254776475 0.280740122906121 ISL1/PTPRM 2 GO:0051546 keratinocyte migration 2/255 19/18722 0.0271307254776475 0.280740122906121 EPB41L4B/ADAM9 2 GO:0061323 cell proliferation involved in heart morphogenesis 2/255 19/18722 0.0271307254776475 0.280740122906121 ISL1/BMPR2 2 GO:0120009 intermembrane lipid transfer 3/255 48/18722 0.027544084538018 0.284076779476259 STARD4/PLEKHA8/ABCA1 3 GO:0097061 dendritic spine organization 4/255 84/18722 0.0277881158401603 0.285650861843753 PPP1R9A/PAK3/ITGA3/DNM1L 4 GO:0071621 granulocyte chemotaxis 5/255 125/18722 0.0282939810124731 0.289897346439274 CXCR2/S100A8/JAM3/PTK2/DNM1L 5 GO:0015833 peptide transport 8/255 264/18722 0.0286287216219186 0.292368480615998 EFNA5/GJA1/S100A8/ISL1/IRS1/SIRT3/CA2/ABCA1 8 GO:0002762 negative regulation of myeloid leukocyte differentiation 3/255 49/18722 0.0290531865628133 0.293822679640102 TLR3/FBN1/PIAS3 3 GO:0007622 rhythmic behavior 3/255 49/18722 0.0290531865628133 0.293822679640102 GPR157/C3orf70/NAGLU 3 GO:0045778 positive regulation of ossification 3/255 49/18722 0.0290531865628133 0.293822679640102 P2RX7/BMPR2/FBN2 3 GO:0008154 actin polymerization or depolymerization 7/255 217/18722 0.0294825392473782 0.29435878478535 KANK4/COBL/PPP1R9A/PAK3/GAS7/ARHGAP28/KANK1 7 GO:0043046 DNA methylation involved in gamete generation 2/255 20/18722 0.0298787881978597 0.29435878478535 PRMT7/PLD6 2 GO:0043691 reverse cholesterol transport 2/255 20/18722 0.0298787881978597 0.29435878478535 CLU/ABCA1 2 GO:0061003 positive regulation of dendritic spine morphogenesis 2/255 20/18722 0.0298787881978597 0.29435878478535 PAK3/DNM1L 2 GO:0071625 vocalization behavior 2/255 20/18722 0.0298787881978597 0.29435878478535 NRXN3/GLI3 2 GO:1902004 positive regulation of amyloid-beta formation 2/255 20/18722 0.0298787881978597 0.29435878478535 CLU/SP1 2 GO:0035023 regulation of Rho protein signal transduction 4/255 86/18722 0.0299539499397572 0.29435878478535 MET/ITGA3/KANK1/ABCA1 4 GO:0046928 regulation of neurotransmitter secretion 4/255 86/18722 0.0299539499397572 0.29435878478535 SYT1/SNCG/PPP1R9A/DNM1L 4 GO:1903510 mucopolysaccharide metabolic process 4/255 86/18722 0.0299539499397572 0.29435878478535 CHST3/ST3GAL6/B3GNT3/GNS 4 GO:0050803 regulation of synapse structure or activity 7/255 218/18722 0.0301215329470091 0.295077713038882 PPP1R9A/PAK3/SIX4/DISC1/CLSTN3/NRP2/DNM1L 7 GO:0015872 dopamine transport 3/255 50/18722 0.0306052730906807 0.298140791099837 SYT1/SNCG/SYT8 3 GO:1990138 neuron projection extension 6/255 172/18722 0.0306250220617753 0.298140791099837 SEMA4G/SYT1/DDR1/DISC1/NRP2/BMPR2 6 GO:0050708 regulation of protein secretion 8/255 268/18722 0.0309059873017972 0.298781521252958 EFNA5/GJA1/NR1H3/ISL1/IRS1/SIRT3/ADAM9/DNM1L 8 GO:0019915 lipid storage 4/255 87/18722 0.0310732782103076 0.298781521252958 NR1H3/STARD4/ITGAV/ABCA1 4 GO:0150104 transport across blood-brain barrier 4/255 87/18722 0.0310732782103076 0.298781521252958 LRP2/SLC16A12/SLC19A1/SLC38A5 4 GO:2000177 regulation of neural precursor cell proliferation 4/255 87/18722 0.0310732782103076 0.298781521252958 GLI3/LRP2/DISC1/ZNF335 4 GO:0001654 eye development 10/255 371/18722 0.0313209244062607 0.300238922606026 FBN1/GLI3/NAGLU/PBX1/KDM5B/TWIST1/TENM3/BMPR2/FBN2/PTPRM 10 GO:0044706 multi-multicellular organism process 7/255 220/18722 0.0314274042870293 0.30033834372161 TEAD3/GJA1/DDR1/ITGA3/ITGB4/SLC19A1/BMPR2 7 GO:0006022 aminoglycan metabolic process 5/255 129/18722 0.0318075385630339 0.300848837191294 CHST3/ST3GAL6/B3GNT3/NAGLU/GNS 5 GO:0021872 forebrain generation of neurons 3/255 51/18722 0.0322002099080253 0.300848837191294 GLI3/DISC1/NRP2 3 GO:0048013 ephrin receptor signaling pathway 3/255 51/18722 0.0322002099080253 0.300848837191294 EFNA5/PAK3/PTK2 3 GO:1903307 positive regulation of regulated secretory pathway 3/255 51/18722 0.0322002099080253 0.300848837191294 SYT1/RAB15/DNM1L 3 GO:0031331 positive regulation of cellular catabolic process 11/255 427/18722 0.0327264022857245 0.300848837191294 LRP2/SH3D19/IRS1/DISC1/CLU/TWIST1/ATG7/P2RX7/HSPBP1/PTK2/ADAM9 11 GO:0007350 blastoderm segmentation 2/255 21/18722 0.0327323534864128 0.300848837191294 NRP2/PLD6 2 GO:0031998 regulation of fatty acid beta-oxidation 2/255 21/18722 0.0327323534864128 0.300848837191294 IRS1/TWIST1 2 GO:0032482 Rab protein signal transduction 2/255 21/18722 0.0327323534864128 0.300848837191294 RAB9B/RAB15 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/255 21/18722 0.0327323534864128 0.300848837191294 SLC26A2/TPST2 2 GO:0034312 diol biosynthetic process 2/255 21/18722 0.0327323534864128 0.300848837191294 ASAH2B/SPR 2 GO:0046519 sphingoid metabolic process 2/255 21/18722 0.0327323534864128 0.300848837191294 ASAH2B/PLPP3 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/255 21/18722 0.0327323534864128 0.300848837191294 SLC26A2/TPST2 2 GO:0060445 branching involved in salivary gland morphogenesis 2/255 21/18722 0.0327323534864128 0.300848837191294 LAMA5/PLXND1 2 GO:0043010 camera-type eye development 9/255 322/18722 0.0328575658531718 0.301114056572322 FBN1/GLI3/NAGLU/KDM5B/TWIST1/TENM3/BMPR2/FBN2/PTPRM 9 GO:0150063 visual system development 10/255 375/18722 0.0333359866145232 0.304605140849079 FBN1/GLI3/NAGLU/PBX1/KDM5B/TWIST1/TENM3/BMPR2/FBN2/PTPRM 10 GO:0030514 negative regulation of BMP signaling pathway 3/255 52/18722 0.0338378408987597 0.307279613796467 FBN1/LRP2/CRIM1 3 GO:0034204 lipid translocation 3/255 52/18722 0.0338378408987597 0.307279613796467 ATP8B1/P2RX7/ABCA1 3 GO:0046942 carboxylic acid transport 8/255 273/18722 0.03392366936313 0.307279613796467 GJA1/LRP2/ATP8B1/SLC16A12/SLC26A2/SLC19A2/SLC19A1/SLC38A5 8 GO:0099175 regulation of postsynapse organization 4/255 90/18722 0.0345776423829119 0.312298070654913 PPP1R9A/PAK3/NRP2/DNM1L 4 GO:0007566 embryo implantation 3/255 53/18722 0.0355179888950554 0.31687956048179 GJA1/DDR1/ITGB4 3 GO:0035561 regulation of chromatin binding 2/255 22/18722 0.0356880617942781 0.31687956048179 DDX11/GMNN 2 GO:0060444 branching involved in mammary gland duct morphogenesis 2/255 22/18722 0.0356880617942781 0.31687956048179 DDR1/KDM5B 2 GO:0071359 cellular response to dsRNA 2/255 22/18722 0.0356880617942781 0.31687956048179 TLR3/ZCCHC3 2 GO:0001657 ureteric bud development 4/255 91/18722 0.035794715152023 0.31687956048179 LAMA5/GLI3/SIX4/PBX1 4 GO:0042147 retrograde transport, endosome to Golgi 4/255 91/18722 0.035794715152023 0.31687956048179 EHD3/EVI5/RAB9B/CLN5 4 GO:0072080 nephron tubule development 4/255 91/18722 0.035794715152023 0.31687956048179 LAMA5/GLI3/SIX4/PBX1 4 GO:0001936 regulation of endothelial cell proliferation 6/255 179/18722 0.0361523980603963 0.319141932030335 GJA1/NRP2/BMPR2/SP1/PTPRM/PDPK1 6 GO:0035249 synaptic transmission, glutamatergic 4/255 92/18722 0.0370363234515822 0.32362256292144 SYT1/CNIH3/DISC1/CLSTN3 4 GO:0072163 mesonephric epithelium development 4/255 92/18722 0.0370363234515822 0.32362256292144 LAMA5/GLI3/SIX4/PBX1 4 GO:0072164 mesonephric tubule development 4/255 92/18722 0.0370363234515822 0.32362256292144 LAMA5/GLI3/SIX4/PBX1 4 GO:0007389 pattern specification process 11/255 436/18722 0.037177760028415 0.32362256292144 CFAP53/COBL/GLI3/ISL1/LRP2/BHLHE41/PBX1/NRP2/INTU/BMPR2/PLD6 11 GO:0048732 gland development 11/255 436/18722 0.037177760028415 0.32362256292144 COBL/LAMA5/MET/DDR1/GLI3/ISL1/SIX4/PBX1/KDM5B/PLXND1/IGSF3 11 GO:0002687 positive regulation of leukocyte migration 5/255 135/18722 0.0375698327039741 0.325182427385848 CXCR2/JAM3/SERPINE1/PTK2/DNM1L 5 GO:0050673 epithelial cell proliferation 11/255 437/18722 0.0376973231664254 0.325182427385848 GJA1/ISL1/SIX4/KDM5B/TWIST1/NRP2/INTU/BMPR2/SP1/PTPRM/PDPK1 11 GO:0009896 positive regulation of catabolic process 12/255 492/18722 0.0377677520828431 0.325182427385848 GJA1/LRP2/SH3D19/IRS1/DISC1/CLU/TWIST1/ATG7/P2RX7/HSPBP1/PTK2/ADAM9 12 GO:0001649 osteoblast differentiation 7/255 229/18722 0.0377731907651401 0.325182427385848 GLI3/CRIM1/TWIST1/BMPR2/FBN2/PTK2/RRBP1 7 GO:0060349 bone morphogenesis 4/255 93/18722 0.0383024917932439 0.325458878395537 GLI3/TWIST1/RAB23/BMPR2 4 GO:0106027 neuron projection organization 4/255 93/18722 0.0383024917932439 0.325458878395537 PPP1R9A/PAK3/ITGA3/DNM1L 4 GO:0016197 endosomal transport 7/255 230/18722 0.0385265629671199 0.325458878395537 EHD3/MYO5B/EVI5/RAB9B/CLN5/ABCA1/DNM1L 7 GO:0072073 kidney epithelium development 5/255 136/18722 0.0385883756112434 0.325458878395537 CXCR2/LAMA5/GLI3/SIX4/PBX1 5 GO:1903305 regulation of regulated secretory pathway 5/255 136/18722 0.0385883756112434 0.325458878395537 SYT1/RAB15/SYT8/PDPK1/DNM1L 5 GO:0003283 atrial septum development 2/255 23/18722 0.0387426248842047 0.325458878395537 ISL1/BMPR2 2 GO:0021884 forebrain neuron development 2/255 23/18722 0.0387426248842047 0.325458878395537 DISC1/NRP2 2 GO:0036303 lymph vessel morphogenesis 2/255 23/18722 0.0387426248842047 0.325458878395537 SVEP1/BMPR2 2 GO:0051590 positive regulation of neurotransmitter transport 2/255 23/18722 0.0387426248842047 0.325458878395537 SYT1/DNM1L 2 GO:0045860 positive regulation of protein kinase activity 10/255 386/18722 0.0393431528827814 0.326712301173624 EFNA5/TLR3/BTC/PPP1R9A/CLU/BMPR2/PTK2/ACSL1/PDPK1/ADAM9 10 GO:0002690 positive regulation of leukocyte chemotaxis 4/255 94/18722 0.0395932372175373 0.326712301173624 CXCR2/SERPINE1/PTK2/DNM1L 4 GO:0030316 osteoclast differentiation 4/255 94/18722 0.0395932372175373 0.326712301173624 TLR3/FBN1/PIAS3/CA2 4 GO:0032091 negative regulation of protein binding 4/255 94/18722 0.0395932372175373 0.326712301173624 DISC1/DDX11/ADAM15/SYMPK 4 GO:0061326 renal tubule development 4/255 94/18722 0.0395932372175373 0.326712301173624 LAMA5/GLI3/SIX4/PBX1 4 GO:0007266 Rho protein signal transduction 5/255 137/18722 0.0396236678863371 0.326712301173624 MET/ITGA3/KANK1/ARHGEF12/ABCA1 5 GO:0050714 positive regulation of protein secretion 5/255 137/18722 0.0396236678863371 0.326712301173624 GJA1/ISL1/SIRT3/ADAM9/DNM1L 5 GO:0031529 ruffle organization 3/255 56/18722 0.0408114647158569 0.333863422086525 COBL/KANK1/ARHGAP24 3 GO:0042733 embryonic digit morphogenesis 3/255 56/18722 0.0408114647158569 0.333863422086525 GLI3/TWIST1/INTU 3 GO:0050433 regulation of catecholamine secretion 3/255 56/18722 0.0408114647158569 0.333863422086525 SYT1/SNCG/SYT8 3 GO:0007369 gastrulation 6/255 185/18722 0.0413700795690982 0.334112755150515 GJA1/COL4A2/ITGA3/ITGB4/BMPR2/ITGAV 6 GO:0048588 developmental cell growth 7/255 234/18722 0.0416384742457127 0.334112755150515 SEMA4G/SYT1/COBL/DDR1/DISC1/NRP2/BMPR2 7 GO:0003181 atrioventricular valve morphogenesis 2/255 24/18722 0.041892824523967 0.334112755150515 TWIST1/BMPR2 2 GO:0021801 cerebral cortex radial glia-guided migration 2/255 24/18722 0.041892824523967 0.334112755150515 GLI3/DISC1 2 GO:0022030 telencephalon glial cell migration 2/255 24/18722 0.041892824523967 0.334112755150515 GLI3/DISC1 2 GO:0048641 regulation of skeletal muscle tissue development 2/255 24/18722 0.041892824523967 0.334112755150515 TWIST1/USP19 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/255 24/18722 0.041892824523967 0.334112755150515 SH3D19/ADAM9 2 GO:0090023 positive regulation of neutrophil chemotaxis 2/255 24/18722 0.041892824523967 0.334112755150515 CXCR2/DNM1L 2 GO:0060271 cilium assembly 9/255 337/18722 0.041909336718777 0.334112755150515 CFAP53/EHD3/LAMA5/TTLL1/PARVA/DISC1/RP2/INTU/RAB23 9 GO:0001823 mesonephros development 4/255 96/18722 0.0422484906738224 0.334112755150515 LAMA5/GLI3/SIX4/PBX1 4 GO:0015914 phospholipid transport 4/255 96/18722 0.0422484906738224 0.334112755150515 ATP8B1/PLEKHA8/P2RX7/ABCA1 4 GO:0120032 regulation of plasma membrane bounded cell projection assembly 6/255 186/18722 0.0422835105418462 0.334112755150515 COBL/PPP1R9A/ATP8B1/KANK1/ARHGAP24/P2RX7 6 GO:0042176 regulation of protein catabolic process 10/255 391/18722 0.0423061160163734 0.334112755150515 GJA1/LRP2/SH3D19/DISC1/CLU/ATG7/HSPBP1/PTK2/ADAM9/USP19 10 GO:0010883 regulation of lipid storage 3/255 57/18722 0.0426595165776177 0.334112755150515 NR1H3/ITGAV/ABCA1 3 GO:0033619 membrane protein proteolysis 3/255 57/18722 0.0426595165776177 0.334112755150515 SH3D19/PSEN2/ADAM9 3 GO:0034205 amyloid-beta formation 3/255 57/18722 0.0426595165776177 0.334112755150515 CLU/PSEN2/SP1 3 GO:1900024 regulation of substrate adhesion-dependent cell spreading 3/255 57/18722 0.0426595165776177 0.334112755150515 EFNA5/KANK1/PTK2 3 GO:0031333 negative regulation of protein-containing complex assembly 5/255 140/18722 0.042830443673444 0.334612841198781 KANK4/ISL1/JAM3/CLU/KANK1 5 GO:0008584 male gonad development 5/255 141/18722 0.0439331194401196 0.342371566709162 TLR3/SIX4/LRP2/FANCA/ADAM15 5 GO:0060491 regulation of cell projection assembly 6/255 188/18722 0.0441482781693809 0.343192460893819 COBL/PPP1R9A/ATP8B1/KANK1/ARHGAP24/P2RX7 6 GO:0035904 aorta development 3/255 58/18722 0.0445489120908967 0.343741605639635 LRP2/ADAMTS6/PLXND1 3 GO:0050432 catecholamine secretion 3/255 58/18722 0.0445489120908967 0.343741605639635 SYT1/SNCG/SYT8 3 GO:0097035 regulation of membrane lipid distribution 3/255 58/18722 0.0445489120908967 0.343741605639635 ATP8B1/P2RX7/ABCA1 3 GO:0046546 development of primary male sexual characteristics 5/255 142/18722 0.0450527208839182 0.344861790966963 TLR3/SIX4/LRP2/FANCA/ADAM15 5 GO:0021846 cell proliferation in forebrain 2/255 25/18722 0.0451355112017562 0.344861790966963 GLI3/DISC1 2 GO:1902993 positive regulation of amyloid precursor protein catabolic process 2/255 25/18722 0.0451355112017562 0.344861790966963 CLU/SP1 2 GO:1905564 positive regulation of vascular endothelial cell proliferation 2/255 25/18722 0.0451355112017562 0.344861790966963 SP1/PDPK1 2 GO:0062013 positive regulation of small molecule metabolic process 5/255 143/18722 0.046189273283259 0.350840613246328 NR1H3/IRS1/TWIST1/STARD4/P2RX7 5 GO:0060996 dendritic spine development 4/255 99/18722 0.0464157057663305 0.350840613246328 PPP1R9A/PAK3/DISC1/DNM1L 4 GO:0060485 mesenchyme development 8/255 291/18722 0.0464286897025663 0.350840613246328 SEMA4G/LAMA5/ISL1/SIX4/TWIST1/NRP2/ADAM15/BMPR2 8 GO:0006767 water-soluble vitamin metabolic process 3/255 59/18722 0.0464793644428736 0.350840613246328 SLC19A2/SLC19A1/SLC52A1 3 GO:0048010 vascular endothelial growth factor receptor signaling pathway 3/255 59/18722 0.0464793644428736 0.350840613246328 BCAR1/EPN2/PTK2 3 GO:0006869 lipid transport 10/255 398/18722 0.0467056486551858 0.351699161560134 NR1H3/ATP8B1/KDM5B/CLU/STARD4/PLEKHA8/P2RX7/ITGAV/ACSL1/ABCA1 10 GO:0050821 protein stabilization 6/255 191/18722 0.0470406934141254 0.35337059355563 PLPP3/PARVA/USP27X/CLU/CTNND1/USP19 6 GO:0051588 regulation of neurotransmitter transport 4/255 100/18722 0.047853864985009 0.35671555571452 SYT1/SNCG/PPP1R9A/DNM1L 4 GO:0002790 peptide secretion 7/255 242/18722 0.0483417988794027 0.35671555571452 EFNA5/GJA1/S100A8/ISL1/IRS1/SIRT3/ABCA1 7 GO:0006027 glycosaminoglycan catabolic process 2/255 26/18722 0.048467602863361 0.35671555571452 NAGLU/GNS 2 GO:0010875 positive regulation of cholesterol efflux 2/255 26/18722 0.048467602863361 0.35671555571452 NR1H3/ABCA1 2 GO:0021680 cerebellar Purkinje cell layer development 2/255 26/18722 0.048467602863361 0.35671555571452 NAGLU/TTLL1 2 GO:0097205 renal filtration 2/255 26/18722 0.048467602863361 0.35671555571452 GJA1/ITGA3 2 GO:0007269 neurotransmitter secretion 5/255 145/18722 0.0485133155771748 0.35671555571452 SYT1/SNCG/PPP1R9A/SYT8/DNM1L 5 GO:0061351 neural precursor cell proliferation 5/255 145/18722 0.0485133155771748 0.35671555571452 TEAD3/GLI3/LRP2/DISC1/ZNF335 5 GO:0099643 signal release from synapse 5/255 145/18722 0.0485133155771748 0.35671555571452 SYT1/SNCG/PPP1R9A/SYT8/DNM1L 5 GO:0010639 negative regulation of organelle organization 9/255 347/18722 0.0488009123350104 0.357987913255651 KANK4/PPP1R9A/MET/ARHGAP28/CLU/KANK1/KNTC1/KATNB1/DNM1L 9 GO:0001935 endothelial cell proliferation 6/255 193/18722 0.0490328261981513 0.358846795946658 GJA1/NRP2/BMPR2/SP1/PTPRM/PDPK1 6 GO:0016358 dendrite development 7/255 243/18722 0.0492252584812867 0.359413394285096 LZTS1/COBL/PPP1R9A/PAK3/SS18L1/DISC1/DNM1L 7 GO:0048813 dendrite morphogenesis 5/255 146/18722 0.0497008395872715 0.362039915408446 LZTS1/PPP1R9A/PAK3/SS18L1/DNM1L 5 GO:0034113 heterotypic cell-cell adhesion 3/255 61/18722 0.0504622146641383 0.365033381540352 JAM3/PARVA/ITGAV 3 GO:0050994 regulation of lipid catabolic process 3/255 61/18722 0.0504622146641383 0.365033381540352 IRS1/TWIST1/IDH1 3 GO:0060997 dendritic spine morphogenesis 3/255 61/18722 0.0504622146641383 0.365033381540352 PPP1R9A/PAK3/DNM1L 3 GO:0006672 ceramide metabolic process 4/255 102/18722 0.0508036295857763 0.365699589192474 ASAH2B/PLPP3/ITGB8/SIRT3 4 GO:1902106 negative regulation of leukocyte differentiation 4/255 102/18722 0.0508036295857763 0.365699589192474 TLR3/FBN1/GLI3/PIAS3 4 GO:0016331 morphogenesis of embryonic epithelium 5/255 147/18722 0.0509053828155923 0.365699589192474 COBL/LAMA5/SIX4/LRP2/TWIST1 5 GO:0003171 atrioventricular valve development 2/255 27/18722 0.0518860836707837 0.369608412191461 TWIST1/BMPR2 2 GO:0008053 mitochondrial fusion 2/255 27/18722 0.0518860836707837 0.369608412191461 PLD6/DNM1L 2 GO:0071624 positive regulation of granulocyte chemotaxis 2/255 27/18722 0.0518860836707837 0.369608412191461 CXCR2/DNM1L 2 GO:0043393 regulation of protein binding 6/255 196/18722 0.0521173139409416 0.369608412191461 DISC1/DDX11/PRMT7/PLXND1/ADAM15/SYMPK 6 GO:0097530 granulocyte migration 5/255 148/18722 0.0521269541940974 0.369608412191461 CXCR2/S100A8/JAM3/PTK2/DNM1L 5 GO:0030593 neutrophil chemotaxis 4/255 103/18722 0.0523151498677451 0.369608412191461 CXCR2/S100A8/JAM3/DNM1L 4 GO:0032760 positive regulation of tumor necrosis factor production 4/255 103/18722 0.0523151498677451 0.369608412191461 TLR3/ISL1/CLU/TWIST1 4 GO:0060113 inner ear receptor cell differentiation 3/255 62/18722 0.0525139632041627 0.369608412191461 TMC1/ATP8B1/NAGLU 3 GO:0060135 maternal process involved in female pregnancy 3/255 62/18722 0.0525139632041627 0.369608412191461 GJA1/ITGA3/BMPR2 3 GO:0032368 regulation of lipid transport 5/255 149/18722 0.0533655594364463 0.374758142109876 NR1H3/KDM5B/ITGAV/ACSL1/ABCA1 5 GO:0030198 extracellular matrix organization 8/255 301/18722 0.0545324428979493 0.381409725622346 ADAMTS19/CCDC80/COL14A1/ADAMTSL4/DDR1/COL4A2/ADAMTS6/ADAM15 8 GO:0001945 lymph vessel development 2/255 28/18722 0.0553880027819472 0.381409725622346 SVEP1/BMPR2 2 GO:0006972 hyperosmotic response 2/255 28/18722 0.0553880027819472 0.381409725622346 TLR3/PDPK1 2 GO:0034123 positive regulation of toll-like receptor signaling pathway 2/255 28/18722 0.0553880027819472 0.381409725622346 TLR3/NR1H3 2 GO:0050996 positive regulation of lipid catabolic process 2/255 28/18722 0.0553880027819472 0.381409725622346 IRS1/TWIST1 2 GO:0051503 adenine nucleotide transport 2/255 28/18722 0.0553880027819472 0.381409725622346 GJA1/SLC19A1 2 GO:1902624 positive regulation of neutrophil migration 2/255 28/18722 0.0553880027819472 0.381409725622346 CXCR2/DNM1L 2 GO:0043062 extracellular structure organization 8/255 302/18722 0.0553895469878095 0.381409725622346 ADAMTS19/CCDC80/COL14A1/ADAMTSL4/DDR1/COL4A2/ADAMTS6/ADAM15 8 GO:0062207 regulation of pattern recognition receptor signaling pathway 4/255 105/18722 0.0554112049384145 0.381409725622346 TLR3/NR1H3/ZCCHC3/PDPK1 4 GO:0007162 negative regulation of cell adhesion 8/255 303/18722 0.0562552232226977 0.385126533003243 EFNA5/GLI3/JAM3/KANK1/SERPINE1/PLXND1/ADAM15/PTK2 8 GO:0015849 organic acid transport 8/255 303/18722 0.0562552232226977 0.385126533003243 GJA1/LRP2/ATP8B1/SLC26A2/SLC19A2/SLC19A1/ACSL1/SLC38A5 8 GO:0002791 regulation of peptide secretion 6/255 200/18722 0.0564105362811108 0.385126533003243 EFNA5/GJA1/S100A8/ISL1/IRS1/SIRT3 6 GO:0002793 positive regulation of peptide secretion 4/255 106/18722 0.056995616112453 0.385126533003243 GJA1/S100A8/ISL1/SIRT3 4 GO:0006766 vitamin metabolic process 4/255 106/18722 0.056995616112453 0.385126533003243 LRP2/SLC19A2/SLC19A1/SLC52A1 4 GO:0042116 macrophage activation 4/255 106/18722 0.056995616112453 0.385126533003243 TLR3/NR1H3/SHPK/CLU 4 GO:1903707 negative regulation of hemopoiesis 4/255 106/18722 0.056995616112453 0.385126533003243 TLR3/FBN1/GLI3/PIAS3 4 GO:0045229 external encapsulating structure organization 8/255 304/18722 0.0571294882236841 0.385126533003243 ADAMTS19/CCDC80/COL14A1/ADAMTSL4/DDR1/COL4A2/ADAMTS6/ADAM15 8 GO:0021915 neural tube development 5/255 152/18722 0.0571835876203215 0.385126533003243 COBL/GLI3/LRP2/TWIST1/INTU 5 GO:0030509 BMP signaling pathway 5/255 152/18722 0.0571835876203215 0.385126533003243 FBN1/LRP2/ITGA3/CRIM1/BMPR2 5 GO:0009952 anterior/posterior pattern specification 6/255 201/18722 0.0575161892486026 0.38552872091495 COBL/GLI3/BHLHE41/PBX1/BMPR2/PLD6 6 GO:0043434 response to peptide hormone 10/255 414/18722 0.0578965759931119 0.38552872091495 FBN1/GJA1/BCAR1/IRS1/KANK1/RAB15/SP1/PTK2/PDPK1/CA2 10 GO:0031532 actin cytoskeleton reorganization 4/255 107/18722 0.0586041903154505 0.38552872091495 CLDN19/BCAR1/PARVA/THSD7A 4 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 4/255 107/18722 0.0586041903154505 0.38552872091495 TLR3/ISL1/CLU/TWIST1 4 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 4/255 107/18722 0.0586041903154505 0.38552872091495 DISC1/CLU/HSPBP1/PTK2 4 GO:0048645 animal organ formation 3/255 65/18722 0.0589063191713921 0.38552872091495 GLI3/ISL1/LRP2 3 GO:0072577 endothelial cell apoptotic process 3/255 65/18722 0.0589063191713921 0.38552872091495 SERPINE1/BMPR2/PDPK1 3 GO:0003209 cardiac atrium morphogenesis 2/255 29/18722 0.0589704731511507 0.38552872091495 ISL1/BMPR2 2 GO:0015701 bicarbonate transport 2/255 29/18722 0.0589704731511507 0.38552872091495 SLC4A2/SLC26A2 2 GO:0015868 purine ribonucleotide transport 2/255 29/18722 0.0589704731511507 0.38552872091495 GJA1/SLC19A1 2 GO:0021522 spinal cord motor neuron differentiation 2/255 29/18722 0.0589704731511507 0.38552872091495 GLI3/ISL1 2 GO:0032366 intracellular sterol transport 2/255 29/18722 0.0589704731511507 0.38552872091495 STARD4/ABCA1 2 GO:0032367 intracellular cholesterol transport 2/255 29/18722 0.0589704731511507 0.38552872091495 STARD4/ABCA1 2 GO:0048665 neuron fate specification 2/255 29/18722 0.0589704731511507 0.38552872091495 GLI3/ISL1 2 GO:0006643 membrane lipid metabolic process 6/255 203/18722 0.0597663882410961 0.388604929906214 ASAH2B/ST3GAL6/PLPP3/ITGB8/GBGT1/SIRT3 6 GO:0032869 cellular response to insulin stimulus 6/255 203/18722 0.0597663882410961 0.388604929906214 BCAR1/IRS1/KANK1/RAB15/SP1/PDPK1 6 GO:0050770 regulation of axonogenesis 5/255 154/18722 0.0598140708111645 0.388604929906214 SEMA4G/PAK3/DISC1/PLXND1/BMPR2 5 GO:1905953 negative regulation of lipid localization 3/255 66/18722 0.0611149052551556 0.395670429247967 NR1H3/ITGAV/ABCA1 3 GO:1903364 positive regulation of cellular protein catabolic process 5/255 155/18722 0.0611548215445657 0.395670429247967 LRP2/DISC1/CLU/HSPBP1/PTK2 5 GO:0072009 nephron epithelium development 4/255 109/18722 0.0618935133845261 0.399622374641827 LAMA5/GLI3/SIX4/PBX1 4 GO:0060348 bone development 6/255 205/18722 0.0620684905062593 0.399925840890846 FBN1/GJA1/GLI3/TWIST1/RAB23/BMPR2 6 GO:0001764 neuron migration 5/255 156/18722 0.0625125577594179 0.400247126469456 IGSF10/ITGA3/DISC1/TWIST1/NRP2 5 GO:0051047 positive regulation of secretion 8/255 310/18722 0.0625562796595077 0.400247126469456 SYT1/GJA1/S100A8/ISL1/RAB15/SIRT3/ADAM9/DNM1L 8 GO:0015865 purine nucleotide transport 2/255 30/18722 0.0626306703499404 0.400247126469456 GJA1/SLC19A1 2 GO:0060603 mammary gland duct morphogenesis 2/255 30/18722 0.0626306703499404 0.400247126469456 DDR1/KDM5B 2 GO:0048863 stem cell differentiation 6/255 206/18722 0.063239015920434 0.40135158035228 SEMA4G/LAMA5/ISL1/TWIST1/NRP2/SETD6 6 GO:0009880 embryonic pattern specification 3/255 67/18722 0.0633617444145149 0.40135158035228 COBL/NRP2/PLD6 3 GO:0042490 mechanoreceptor differentiation 3/255 67/18722 0.0633617444145149 0.40135158035228 TMC1/ATP8B1/NAGLU 3 GO:0050435 amyloid-beta metabolic process 3/255 67/18722 0.0633617444145149 0.40135158035228 CLU/PSEN2/SP1 3 GO:0003014 renal system process 4/255 110/18722 0.0635740903278011 0.40135158035228 GJA1/BTC/MYO5B/ITGA3 4 GO:0014812 muscle cell migration 4/255 110/18722 0.0635740903278011 0.40135158035228 DDR1/SIX4/PARVA/SERPINE1 4 GO:0050679 positive regulation of epithelial cell proliferation 6/255 207/18722 0.0644225262889278 0.405887892445362 KDM5B/TWIST1/NRP2/BMPR2/SP1/PDPK1 6 GO:0001938 positive regulation of endothelial cell proliferation 4/255 111/18722 0.0652784866765049 0.409629057959996 NRP2/BMPR2/SP1/PDPK1 4 GO:0090288 negative regulation of cellular response to growth factor stimulus 4/255 111/18722 0.0652784866765049 0.409629057959996 FBN1/LRP2/EPN2/CRIM1 4 GO:0044782 cilium organization 9/255 368/18722 0.065615037314353 0.410290199388489 CFAP53/EHD3/LAMA5/TTLL1/PARVA/DISC1/RP2/INTU/RAB23 9 GO:0042987 amyloid precursor protein catabolic process 3/255 68/18722 0.0656464319021583 0.410290199388489 CLU/PSEN2/SP1 3 GO:0060390 regulation of SMAD protein signal transduction 2/255 31/18722 0.0663658314080631 0.41395852924191 PBLD/BMPR2 2 GO:0071222 cellular response to lipopolysaccharide 6/255 209/18722 0.0668284976573593 0.416014054141928 NR1H3/SHPK/LDOC1/SERPINE1/ADAM9/ABCA1 6 GO:0050808 synapse organization 10/255 426/18722 0.0673572085540088 0.418471723123812 SNCG/PPP1R9A/PAK3/SIX4/ITGA3/DISC1/CLSTN3/NRP2/PLXND1/DNM1L 10 GO:0045665 negative regulation of neuron differentiation 3/255 69/18722 0.0679685528397733 0.41863754619641 GLI3/ISL1/PBX1 3 GO:0045669 positive regulation of osteoblast differentiation 3/255 69/18722 0.0679685528397733 0.41863754619641 GLI3/BMPR2/FBN2 3 GO:0007623 circadian rhythm 6/255 210/18722 0.0680509521760845 0.41863754619641 GPR157/NR1H3/C3orf70/BHLHE41/NAGLU/ATG7 6 GO:0035637 multicellular organismal signaling 5/255 160/18722 0.0681129271209696 0.41863754619641 EHD3/GJA1/CLDN19/ISL1/JAM3 5 GO:0032103 positive regulation of response to external stimulus 10/255 427/18722 0.0681876835244712 0.41863754619641 TLR3/CXCR2/S100A8/PAK3/MET/ZCCHC3/SERPINE1/BMPR2/PTK2/DNM1L 10 GO:0043254 regulation of protein-containing complex assembly 10/255 427/18722 0.0681876835244712 0.41863754619641 KANK4/PPP1R9A/PAK3/MET/ISL1/JAM3/ARHGAP28/CLU/KANK1/ABCA1 10 GO:0003018 vascular process in circulatory system 7/255 263/18722 0.0690630877607959 0.422352542568468 GJA1/CXCR2/LRP2/SLC16A12/SLC19A1/BMPR2/SLC38A5 7 GO:0043588 skin development 7/255 263/18722 0.0690630877607959 0.422352542568468 LAMA5/MET/FRAS1/ITGA3/ITGB4/INTU/ADAM9 7 GO:0006026 aminoglycan catabolic process 2/255 32/18722 0.0701732536741798 0.422526816438944 NAGLU/GNS 2 GO:0007435 salivary gland morphogenesis 2/255 32/18722 0.0701732536741798 0.422526816438944 LAMA5/PLXND1 2 GO:0009954 proximal/distal pattern formation 2/255 32/18722 0.0701732536741798 0.422526816438944 GLI3/PBX1 2 GO:0021799 cerebral cortex radially oriented cell migration 2/255 32/18722 0.0701732536741798 0.422526816438944 GLI3/DISC1 2 GO:0048841 regulation of axon extension involved in axon guidance 2/255 32/18722 0.0701732536741798 0.422526816438944 SEMA4G/BMPR2 2 GO:0060317 cardiac epithelial to mesenchymal transition 2/255 32/18722 0.0701732536741798 0.422526816438944 TWIST1/ADAM15 2 GO:0060914 heart formation 2/255 32/18722 0.0701732536741798 0.422526816438944 ISL1/LRP2 2 GO:0061036 positive regulation of cartilage development 2/255 32/18722 0.0701732536741798 0.422526816438944 GLI3/BMPR2 2 GO:0030258 lipid modification 6/255 212/18722 0.0705347696573273 0.423886836882976 PLPP3/ACADS/IRS1/TWIST1/STARD4/GBGT1 6 GO:0051100 negative regulation of binding 5/255 162/18722 0.0710143819694317 0.425949987820488 ARHGAP28/DISC1/DDX11/ADAM15/SYMPK 5 GO:0050806 positive regulation of synaptic transmission 5/255 164/18722 0.073982987216768 0.439937581368926 SYT1/PPP1R9A/CLSTN3/MPP2/DNM1L 5 GO:0042558 pteridine-containing compound metabolic process 2/255 33/18722 0.0740502936960177 0.439937581368926 SPR/SLC19A1 2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 2/255 33/18722 0.0740502936960177 0.439937581368926 IRS1/PTK2 2 GO:0046320 regulation of fatty acid oxidation 2/255 33/18722 0.0740502936960177 0.439937581368926 IRS1/TWIST1 2 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 2/255 33/18722 0.0740502936960177 0.439937581368926 KANK1/ARHGAP24 2 GO:0046661 male sex differentiation 5/255 165/18722 0.0754923700568797 0.445120106467451 TLR3/SIX4/LRP2/FANCA/ADAM15 5 GO:0050796 regulation of insulin secretion 5/255 165/18722 0.0754923700568797 0.445120106467451 EFNA5/GJA1/ISL1/IRS1/SIRT3 5 GO:0071772 response to BMP 5/255 165/18722 0.0754923700568797 0.445120106467451 FBN1/LRP2/ITGA3/CRIM1/BMPR2 5 GO:0071773 cellular response to BMP stimulus 5/255 165/18722 0.0754923700568797 0.445120106467451 FBN1/LRP2/ITGA3/CRIM1/BMPR2 5 GO:0030301 cholesterol transport 4/255 117/18722 0.0759990851165567 0.447263919000451 NR1H3/CLU/STARD4/ABCA1 4 GO:0030307 positive regulation of cell growth 5/255 166/18722 0.0770184134755281 0.452410793441777 SYT1/S100A8/N6AMT1/DISC1/BMPR2 5 GO:0051937 catecholamine transport 3/255 73/18722 0.0776227485019857 0.453877828908553 SYT1/SNCG/SYT8 3 GO:0007431 salivary gland development 2/255 34/18722 0.0779943661196457 0.453877828908553 LAMA5/PLXND1 2 GO:0044319 wound healing, spreading of cells 2/255 34/18722 0.0779943661196457 0.453877828908553 DDR1/ARHGAP24 2 GO:0090505 epiboly involved in wound healing 2/255 34/18722 0.0779943661196457 0.453877828908553 DDR1/ARHGAP24 2 GO:2000352 negative regulation of endothelial cell apoptotic process 2/255 34/18722 0.0779943661196457 0.453877828908553 SERPINE1/PDPK1 2 GO:0032535 regulation of cellular component size 9/255 382/18722 0.0786404921180228 0.456787245109333 SEMA4G/KANK4/PPP1R9A/PAK3/ARHGAP28/DISC1/KANK1/P2RX7/BMPR2 9 GO:0034764 positive regulation of transmembrane transport 6/255 219/18722 0.079635515370972 0.458017525606131 EHD3/IRS1/P2RX7/ACSL1/PDPK1/CA2 6 GO:0030282 bone mineralization 4/255 119/18722 0.079758012241601 0.458017525606131 TWIST1/P2RX7/BMPR2/FBN2 4 GO:0099173 postsynapse organization 5/255 168/18722 0.0801202868475867 0.458017525606131 PPP1R9A/PAK3/ITGA3/NRP2/DNM1L 5 GO:0006635 fatty acid beta-oxidation 3/255 74/18722 0.0801254955736922 0.458017525606131 ACADS/IRS1/TWIST1 3 GO:0007040 lysosome organization 3/255 74/18722 0.0801254955736922 0.458017525606131 NAGLU/CLN5/ABCA1 3 GO:0070972 protein localization to endoplasmic reticulum 3/255 74/18722 0.0801254955736922 0.458017525606131 GJA1/KDELR3/BHLHE40-AS1 3 GO:0080171 lytic vacuole organization 3/255 74/18722 0.0801254955736922 0.458017525606131 NAGLU/CLN5/ABCA1 3 GO:0007015 actin filament organization 10/255 441/18722 0.0805020947830077 0.458017525606131 KANK4/MYO5B/COBL/PPP1R9A/PAK3/MET/BCAR1/GAS7/ARHGAP28/KANK1 10 GO:0030111 regulation of Wnt signaling pathway 8/255 328/18722 0.0807185802270917 0.458017525606131 RNF43/GLI3/ISL1/ITGA3/PLPP3/DISC1/KANK1/CTNND1 8 GO:0048705 skeletal system morphogenesis 6/255 220/18722 0.0809871446536993 0.458017525606131 GLI3/SIX4/TWIST1/RAB23/BMPR2/FBN2 6 GO:0097529 myeloid leukocyte migration 6/255 220/18722 0.0809871446536993 0.458017525606131 CXCR2/S100A8/JAM3/SERPINE1/PTK2/DNM1L 6 GO:0002761 regulation of myeloid leukocyte differentiation 4/255 120/18722 0.081671641085851 0.458017525606131 TLR3/FBN1/PIAS3/CA2 4 GO:0048675 axon extension 4/255 120/18722 0.081671641085851 0.458017525606131 SEMA4G/DISC1/NRP2/BMPR2 4 GO:0031214 biomineral tissue development 5/255 169/18722 0.0816960124363294 0.458017525606131 SLC4A2/TWIST1/P2RX7/BMPR2/FBN2 5 GO:0001893 maternal placenta development 2/255 35/18722 0.0820029426075651 0.458017525606131 GJA1/BMPR2 2 GO:0003351 epithelial cilium movement involved in extracellular fluid movement 2/255 35/18722 0.0820029426075651 0.458017525606131 CFAP53/TTLL1 2 GO:0006739 NADP metabolic process 2/255 35/18722 0.0820029426075651 0.458017525606131 SHPK/IDH1 2 GO:0035633 maintenance of blood-brain barrier 2/255 35/18722 0.0820029426075651 0.458017525606131 GJA1/JAM3 2 GO:0046627 negative regulation of insulin receptor signaling pathway 2/255 35/18722 0.0820029426075651 0.458017525606131 IRS1/KANK1 2 GO:0071108 protein K48-linked deubiquitination 2/255 35/18722 0.0820029426075651 0.458017525606131 USP27X/USP19 2 GO:0090504 epiboly 2/255 35/18722 0.0820029426075651 0.458017525606131 DDR1/ARHGAP24 2 GO:0008406 gonad development 6/255 221/18722 0.0823515939138616 0.458017525606131 TLR3/SIX4/LRP2/FANCA/IDH1/ADAM15 6 GO:0071219 cellular response to molecule of bacterial origin 6/255 221/18722 0.0823515939138616 0.458017525606131 NR1H3/SHPK/LDOC1/SERPINE1/ADAM9/ABCA1 6 GO:0006024 glycosaminoglycan biosynthetic process 3/255 75/18722 0.0826630030213946 0.458017525606131 CHST3/ST3GAL6/B3GNT3 3 GO:0034121 regulation of toll-like receptor signaling pathway 3/255 75/18722 0.0826630030213946 0.458017525606131 TLR3/NR1H3/PDPK1 3 GO:0051453 regulation of intracellular pH 3/255 75/18722 0.0826630030213946 0.458017525606131 SLC4A2/CLN5/CA2 3 GO:0001838 embryonic epithelial tube formation 4/255 121/18722 0.0836078543367465 0.462432822658996 COBL/SIX4/LRP2/TWIST1 4 GO:0007548 sex differentiation 7/255 276/18722 0.0841963171596323 0.464864825307157 TLR3/SIX4/LRP2/PBX1/FANCA/IDH1/ADAM15 7 GO:0030833 regulation of actin filament polymerization 5/255 171/18722 0.0848967605588777 0.467081649201572 KANK4/PPP1R9A/PAK3/ARHGAP28/KANK1 5 GO:0110148 biomineralization 5/255 171/18722 0.0848967605588777 0.467081649201572 SLC4A2/TWIST1/P2RX7/BMPR2/FBN2 5 GO:0006305 DNA alkylation 3/255 76/18722 0.0852347992209643 0.46729604836055 N6AMT1/PRMT7/PLD6 3 GO:0006306 DNA methylation 3/255 76/18722 0.0852347992209643 0.46729604836055 N6AMT1/PRMT7/PLD6 3 GO:1990266 neutrophil migration 4/255 122/18722 0.0855665020363992 0.468293027782395 CXCR2/S100A8/JAM3/DNM1L 4 GO:0003203 endocardial cushion morphogenesis 2/255 36/18722 0.0860735507753079 0.46860600378543 ISL1/TWIST1 2 GO:0003230 cardiac atrium development 2/255 36/18722 0.0860735507753079 0.46860600378543 ISL1/BMPR2 2 GO:0010762 regulation of fibroblast migration 2/255 36/18722 0.0860735507753079 0.46860600378543 PAK3/PTK2 2 GO:0010876 lipid localization 10/255 448/18722 0.0871433544936747 0.473605187465623 NR1H3/ATP8B1/KDM5B/CLU/STARD4/PLEKHA8/P2RX7/ITGAV/ACSL1/ABCA1 10 GO:0031016 pancreas development 3/255 77/18722 0.08784040629734 0.475438362613934 MET/ISL1/PDPK1 3 GO:0140056 organelle localization by membrane tethering 3/255 77/18722 0.08784040629734 0.475438362613934 SYT1/PSEN2/RAB15 3 GO:0016485 protein processing 6/255 225/18722 0.0879370795490732 0.475438362613934 ENPEP/GLI3/PISD/PSEN2/CLN5/SERPINE1 6 GO:0003161 cardiac conduction system development 2/255 37/18722 0.0902037731462441 0.480047434998897 GJA1/ISL1 2 GO:0003176 aortic valve development 2/255 37/18722 0.0902037731462441 0.480047434998897 TWIST1/BMPR2 2 GO:0006862 nucleotide transport 2/255 37/18722 0.0902037731462441 0.480047434998897 GJA1/SLC19A1 2 GO:0016202 regulation of striated muscle tissue development 2/255 37/18722 0.0902037731462441 0.480047434998897 TWIST1/USP19 2 GO:0031112 positive regulation of microtubule polymerization or depolymerization 2/255 37/18722 0.0902037731462441 0.480047434998897 MET/KATNB1 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/255 37/18722 0.0902037731462441 0.480047434998897 CRIM1/IRS1 2 GO:0090218 positive regulation of lipid kinase activity 2/255 37/18722 0.0902037731462441 0.480047434998897 IRS1/PTK2 2 GO:1900077 negative regulation of cellular response to insulin stimulus 2/255 37/18722 0.0902037731462441 0.480047434998897 IRS1/KANK1 2 GO:1905332 positive regulation of morphogenesis of an epithelium 2/255 37/18722 0.0902037731462441 0.480047434998897 GJA1/SIX4 2 GO:0032024 positive regulation of insulin secretion 3/255 78/18722 0.0904793405485921 0.480047434998897 GJA1/ISL1/SIRT3 3 GO:0061045 negative regulation of wound healing 3/255 78/18722 0.0904793405485921 0.480047434998897 GJA1/CLDN19/SERPINE1 3 GO:0045137 development of primary sexual characteristics 6/255 227/18722 0.090806032809969 0.480964156832463 TLR3/SIX4/LRP2/FANCA/IDH1/ADAM15 6 GO:1903532 positive regulation of secretion by cell 7/255 282/18722 0.091774751281577 0.485272585033719 SYT1/GJA1/ISL1/RAB15/SIRT3/ADAM9/DNM1L 7 GO:0006023 aminoglycan biosynthetic process 3/255 79/18722 0.0931511128574655 0.490062672861245 CHST3/ST3GAL6/B3GNT3 3 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 3/255 79/18722 0.0931511128574655 0.490062672861245 PAK3/SS18L1/DNM1L 3 GO:0050772 positive regulation of axonogenesis 3/255 79/18722 0.0931511128574655 0.490062672861245 DISC1/PLXND1/BMPR2 3 GO:0000578 embryonic axis specification 2/255 38/18722 0.0943912461243023 0.490803068449991 COBL/PLD6 2 GO:0006858 extracellular transport 2/255 38/18722 0.0943912461243023 0.490803068449991 CFAP53/TTLL1 2 GO:0007007 inner mitochondrial membrane organization 2/255 38/18722 0.0943912461243023 0.490803068449991 TIMM8A/CHCHD6 2 GO:0032373 positive regulation of sterol transport 2/255 38/18722 0.0943912461243023 0.490803068449991 NR1H3/ABCA1 2 GO:0032376 positive regulation of cholesterol transport 2/255 38/18722 0.0943912461243023 0.490803068449991 NR1H3/ABCA1 2 GO:0097242 amyloid-beta clearance 2/255 38/18722 0.0943912461243023 0.490803068449991 LRP2/CLU 2 GO:2000279 negative regulation of DNA biosynthetic process 2/255 38/18722 0.0943912461243023 0.490803068449991 GJA1/BMPR2 2 GO:0030595 leukocyte chemotaxis 6/255 230/18722 0.0952039898921682 0.494206758161172 CXCR2/S100A8/JAM3/SERPINE1/PTK2/DNM1L 6 GO:0120193 tight junction organization 3/255 80/18722 0.0958552290906861 0.49593972004701 GJA1/CLDN19/SVEP1 3 GO:1901264 carbohydrate derivative transport 3/255 80/18722 0.0958552290906861 0.49593972004701 GJA1/PLEKHA8/SLC19A1 3 GO:0032496 response to lipopolysaccharide 8/255 343/18722 0.0980183432269544 0.505295384140934 GJA1/NR1H3/S100A8/SHPK/LDOC1/SERPINE1/ADAM9/ABCA1 8 GO:0032271 regulation of protein polymerization 6/255 232/18722 0.098198548286446 0.505295384140934 KANK4/PPP1R9A/PAK3/MET/ARHGAP28/KANK1 6 GO:0030641 regulation of cellular pH 3/255 81/18722 0.0985911904863175 0.505295384140934 SLC4A2/CLN5/CA2 3 GO:0017158 regulation of calcium ion-dependent exocytosis 2/255 39/18722 0.0986336589843104 0.505295384140934 SYT1/SYT8 2 GO:0036297 interstrand cross-link repair 2/255 39/18722 0.0986336589843104 0.505295384140934 FANCA/EXO5 2 GO:1901861 regulation of muscle tissue development 2/255 39/18722 0.0986336589843104 0.505295384140934 TWIST1/USP19 2 GO:0007498 mesoderm development 4/255 129/18722 0.0998917152329599 0.51030093673986 GJA1/ITGA3/ITGB4/BMPR2 4 GO:0007033 vacuole organization 5/255 180/18722 0.100100631750891 0.51030093673986 NAGLU/CLN5/ATG7/RAB23/ABCA1 5 GO:0015698 inorganic anion transport 5/255 180/18722 0.100100631750891 0.51030093673986 ATP8B1/GABRE/SLC4A2/SLC13A4/SLC26A2 5 GO:0046889 positive regulation of lipid biosynthetic process 3/255 82/18722 0.101358494029444 0.515032998117091 NR1H3/STARD4/SIRT3 3 GO:1905897 regulation of response to endoplasmic reticulum stress 3/255 82/18722 0.101358494029444 0.515032998117091 NR1H3/CLU/USP19 3 GO:1905952 regulation of lipid localization 5/255 181/18722 0.101869347804994 0.516733890667709 NR1H3/KDM5B/ITGAV/ACSL1/ABCA1 5 GO:0015918 sterol transport 4/255 130/18722 0.102023939373432 0.516733890667709 NR1H3/CLU/STARD4/ABCA1 4 GO:0030866 cortical actin cytoskeleton organization 2/255 40/18722 0.102928752879673 0.519632233843258 STRIP1/FMNL2 2 GO:0070266 necroptotic process 2/255 40/18722 0.102928752879673 0.519632233843258 TLR3/DNM1L 2 GO:0048678 response to axon injury 3/255 83/18722 0.104156632816449 0.524983028308713 ISL1/JAM3/MORN4 3 GO:0048762 mesenchymal cell differentiation 6/255 236/18722 0.104336394691133 0.525042243816089 SEMA4G/LAMA5/ISL1/TWIST1/NRP2/ADAM15 6 GO:0072175 epithelial tube formation 4/255 132/18722 0.10635090367651 0.533809314625296 COBL/SIX4/LRP2/TWIST1 4 GO:0015844 monoamine transport 3/255 84/18722 0.106985096408163 0.533809314625296 SYT1/SNCG/SYT8 3 GO:0032370 positive regulation of lipid transport 3/255 84/18722 0.106985096408163 0.533809314625296 NR1H3/ACSL1/ABCA1 3 GO:0001953 negative regulation of cell-matrix adhesion 2/255 41/18722 0.107274319867099 0.533809314625296 SERPINE1/ADAM15 2 GO:0032735 positive regulation of interleukin-12 production 2/255 41/18722 0.107274319867099 0.533809314625296 TLR3/ISL1 2 GO:0048634 regulation of muscle organ development 2/255 41/18722 0.107274319867099 0.533809314625296 TWIST1/USP19 2 GO:1905314 semi-lunar valve development 2/255 41/18722 0.107274319867099 0.533809314625296 TWIST1/BMPR2 2 GO:0051259 protein complex oligomerization 6/255 238/18722 0.107478960748212 0.533977348709319 SYT1/EHD3/MPP2/KCNG1/TRMT61B/DNM1L 6 GO:0010565 regulation of cellular ketone metabolic process 4/255 133/18722 0.108545263158724 0.53756568521555 NR1H3/IRS1/TWIST1/STARD4 4 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 4/255 133/18722 0.108545263158724 0.53756568521555 DISC1/CLU/HSPBP1/PTK2 4 GO:0010507 negative regulation of autophagy 3/255 85/18722 0.109843371172132 0.543133757773596 LZTS1/MET/ATG7 3 GO:0070085 glycosylation 6/255 240/18722 0.110670102659894 0.545254892324769 ST3GAL6/B3GNT3/COG6/CLN5/GALNT3/GBGT1 6 GO:0019432 triglyceride biosynthetic process 2/255 42/18722 0.111668201948113 0.545254892324769 NR1H3/ACSL1 2 GO:0021795 cerebral cortex cell migration 2/255 42/18722 0.111668201948113 0.545254892324769 GLI3/DISC1 2 GO:0021879 forebrain neuron differentiation 2/255 42/18722 0.111668201948113 0.545254892324769 DISC1/NRP2 2 GO:0045214 sarcomere organization 2/255 42/18722 0.111668201948113 0.545254892324769 TNNT3/SIX4 2 GO:0045773 positive regulation of axon extension 2/255 42/18722 0.111668201948113 0.545254892324769 DISC1/BMPR2 2 GO:0051452 intracellular pH reduction 2/255 42/18722 0.111668201948113 0.545254892324769 CLN5/CA2 2 GO:0072595 maintenance of protein localization in organelle 2/255 42/18722 0.111668201948113 0.545254892324769 GJA1/KDELR3 2 GO:0022406 membrane docking 3/255 86/18722 0.112730940614266 0.548239483949941 SYT1/PSEN2/RAB15 3 GO:0045921 positive regulation of exocytosis 3/255 86/18722 0.112730940614266 0.548239483949941 SYT1/RAB15/DNM1L 3 GO:0008064 regulation of actin polymerization or depolymerization 5/255 187/18722 0.11280575621754 0.548239483949941 KANK4/PPP1R9A/PAK3/ARHGAP28/KANK1 5 GO:0042157 lipoprotein metabolic process 4/255 135/18722 0.112994761060203 0.5483053234676 ATG7/ITGAV/ABCA1/ZDHHC13 4 GO:0030832 regulation of actin filament length 5/255 188/18722 0.114681643595905 0.554768012751088 KANK4/PPP1R9A/PAK3/ARHGAP28/KANK1 5 GO:0048839 inner ear development 5/255 188/18722 0.114681643595905 0.554768012751088 TMC1/GLI3/SIX4/ATP8B1/NAGLU 5 GO:0044070 regulation of anion transport 3/255 87/18722 0.115647285700122 0.555430987617267 ATP8B1/GABRE/CA2 3 GO:0048041 focal adhesion assembly 3/255 87/18722 0.115647285700122 0.555430987617267 EFNA5/PTK2/PDPK1 3 GO:0032956 regulation of actin cytoskeleton organization 8/255 357/18722 0.115916632449966 0.555430987617267 EFNA5/KANK4/PPP1R9A/PAK3/MET/JAM3/ARHGAP28/KANK1 8 GO:0009268 response to pH 2/255 43/18722 0.116108290127053 0.555430987617267 GJA1/CA2 2 GO:0016266 O-glycan processing 2/255 43/18722 0.116108290127053 0.555430987617267 B3GNT3/GALNT3 2 GO:0006898 receptor-mediated endocytosis 6/255 244/18722 0.117196422960495 0.555430987617267 CXCR2/ASGR1/LRP2/CLU/SERPINE1/ITGAV 6 GO:0060078 regulation of postsynaptic membrane potential 4/255 137/18722 0.117523961129799 0.555430987617267 PPP1R9A/GABRE/MPP2/P2RX7 4 GO:0042063 gliogenesis 7/255 301/18722 0.11819661402422 0.555430987617267 GPR157/S100A8/GLI3/LRP2/DISC1/CLU/ITGB4 7 GO:0001843 neural tube closure 3/255 88/18722 0.118591885166058 0.555430987617267 COBL/LRP2/TWIST1 3 GO:0071216 cellular response to biotic stimulus 6/255 246/18722 0.120530702195013 0.555430987617267 NR1H3/SHPK/LDOC1/SERPINE1/ADAM9/ABCA1 6 GO:0021517 ventral spinal cord development 2/255 44/18722 0.120592523485321 0.555430987617267 GLI3/ISL1 2 GO:0045124 regulation of bone resorption 2/255 44/18722 0.120592523485321 0.555430987617267 P2RX7/CA2 2 GO:1903573 negative regulation of response to endoplasmic reticulum stress 2/255 44/18722 0.120592523485321 0.555430987617267 NR1H3/CLU 2 GO:0060606 tube closure 3/255 89/18722 0.121564215820506 0.555430987617267 COBL/LRP2/TWIST1 3 GO:0006816 calcium ion transport 9/255 422/18722 0.12394606923079 0.555430987617267 EHD3/GJA1/TMC1/CATSPER2/PSEN2/P2RX7/ITGAV/PDPK1/DNM1L 9 GO:0002237 response to molecule of bacterial origin 8/255 363/18722 0.124093198148691 0.555430987617267 GJA1/NR1H3/S100A8/SHPK/LDOC1/SERPINE1/ADAM9/ABCA1 8 GO:0045638 negative regulation of myeloid cell differentiation 3/255 90/18722 0.124563752835595 0.555430987617267 TLR3/FBN1/PIAS3 3 GO:0046849 bone remodeling 3/255 90/18722 0.124563752835595 0.555430987617267 GJA1/P2RX7/CA2 3 GO:0035987 endodermal cell differentiation 2/255 45/18722 0.125118888271586 0.555430987617267 COL4A2/ITGAV 2 GO:0048538 thymus development 2/255 45/18722 0.125118888271586 0.555430987617267 SIX4/PBX1 2 GO:0071364 cellular response to epidermal growth factor stimulus 2/255 45/18722 0.125118888271586 0.555430987617267 GAREM1/PDPK1 2 GO:0046883 regulation of hormone secretion 6/255 249/18722 0.125619675167778 0.555430987617267 EFNA5/GJA1/ISL1/KDM5B/IRS1/SIRT3 6 GO:0016571 histone methylation 4/255 141/18722 0.126814850225864 0.555430987617267 N6AMT1/PRMT7/SETD6/ZNF335 4 GO:0006885 regulation of pH 3/255 91/18722 0.127589970029354 0.555430987617267 SLC4A2/CLN5/CA2 3 GO:0051492 regulation of stress fiber assembly 3/255 91/18722 0.127589970029354 0.555430987617267 PPP1R9A/MET/ARHGAP28 3 GO:0051952 regulation of amine transport 3/255 91/18722 0.127589970029354 0.555430987617267 SYT1/SNCG/SYT8 3 GO:0098661 inorganic anion transmembrane transport 3/255 91/18722 0.127589970029354 0.555430987617267 GABRE/SLC13A4/SLC26A2 3 GO:0002002 regulation of angiotensin levels in blood 1/255 10/18722 0.128180329135944 0.555430987617267 ENPEP 1 GO:0002003 angiotensin maturation 1/255 10/18722 0.128180329135944 0.555430987617267 ENPEP 1 GO:0003163 sinoatrial node development 1/255 10/18722 0.128180329135944 0.555430987617267 ISL1 1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1/255 10/18722 0.128180329135944 0.555430987617267 TSEN15 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/255 10/18722 0.128180329135944 0.555430987617267 PISD 1 GO:0007028 cytoplasm organization 1/255 10/18722 0.128180329135944 0.555430987617267 PLD6 1 GO:0010944 negative regulation of transcription by competitive promoter binding 1/255 10/18722 0.128180329135944 0.555430987617267 BHLHE41 1 GO:0015808 L-alanine transport 1/255 10/18722 0.128180329135944 0.555430987617267 SLC38A5 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/255 10/18722 0.128180329135944 0.555430987617267 ACSL1 1 GO:0016559 peroxisome fission 1/255 10/18722 0.128180329135944 0.555430987617267 DNM1L 1 GO:0018242 protein O-linked glycosylation via serine 1/255 10/18722 0.128180329135944 0.555430987617267 GALNT3 1 GO:0019532 oxalate transport 1/255 10/18722 0.128180329135944 0.555430987617267 SLC26A2 1 GO:0031340 positive regulation of vesicle fusion 1/255 10/18722 0.128180329135944 0.555430987617267 SYT1 1 GO:0032070 regulation of deoxyribonuclease activity 1/255 10/18722 0.128180329135944 0.555430987617267 DDX11 1 GO:0034085 establishment of sister chromatid cohesion 1/255 10/18722 0.128180329135944 0.555430987617267 DDX11 1 GO:0035376 sterol import 1/255 10/18722 0.128180329135944 0.555430987617267 STARD4 1 GO:0038007 netrin-activated signaling pathway 1/255 10/18722 0.128180329135944 0.555430987617267 PTK2 1 GO:0051006 positive regulation of lipoprotein lipase activity 1/255 10/18722 0.128180329135944 0.555430987617267 NR1H3 1 GO:0051660 establishment of centrosome localization 1/255 10/18722 0.128180329135944 0.555430987617267 PARD3B 1 GO:0051918 negative regulation of fibrinolysis 1/255 10/18722 0.128180329135944 0.555430987617267 SERPINE1 1 GO:0060068 vagina development 1/255 10/18722 0.128180329135944 0.555430987617267 LRP2 1 GO:0070508 cholesterol import 1/255 10/18722 0.128180329135944 0.555430987617267 STARD4 1 GO:0090527 actin filament reorganization 1/255 10/18722 0.128180329135944 0.555430987617267 BCAR1 1 GO:0099532 synaptic vesicle endosomal processing 1/255 10/18722 0.128180329135944 0.555430987617267 DNM1L 1 GO:1900246 positive regulation of RIG-I signaling pathway 1/255 10/18722 0.128180329135944 0.555430987617267 ZCCHC3 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/255 10/18722 0.128180329135944 0.555430987617267 DDX11 1 GO:1904350 regulation of protein catabolic process in the vacuole 1/255 10/18722 0.128180329135944 0.555430987617267 LRP2 1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 1/255 10/18722 0.128180329135944 0.555430987617267 PDPK1 1 GO:1990700 nucleolar chromatin organization 1/255 10/18722 0.128180329135944 0.555430987617267 DDX11 1 GO:0030073 insulin secretion 5/255 195/18722 0.128224972136861 0.555430987617267 EFNA5/GJA1/ISL1/IRS1/SIRT3 5 GO:0046467 membrane lipid biosynthetic process 4/255 142/18722 0.129184767018384 0.555430987617267 ASAH2B/PLPP3/GBGT1/SIRT3 4 GO:0045851 pH reduction 2/255 46/18722 0.129685417007704 0.555430987617267 CLN5/CA2 2 GO:0055010 ventricular cardiac muscle tissue morphogenesis 2/255 46/18722 0.129685417007704 0.555430987617267 ISL1/LRP2 2 GO:0090329 regulation of DNA-dependent DNA replication 2/255 46/18722 0.129685417007704 0.555430987617267 ATG7/GMNN 2 GO:0090276 regulation of peptide hormone secretion 5/255 196/18722 0.130217319210053 0.555430987617267 EFNA5/GJA1/ISL1/IRS1/SIRT3 5 GO:0048568 embryonic organ development 9/255 427/18722 0.130434943644223 0.555430987617267 FBN1/TEAD3/COBL/GLI3/SIX4/NAGLU/PBX1/TWIST1/FBN2 9 GO:0006497 protein lipidation 3/255 92/18722 0.130642340138717 0.555430987617267 ATG7/ABCA1/ZDHHC13 3 GO:0019217 regulation of fatty acid metabolic process 3/255 93/18722 0.133720335083566 0.555430987617267 NR1H3/IRS1/TWIST1 3 GO:0032755 positive regulation of interleukin-6 production 3/255 93/18722 0.133720335083566 0.555430987617267 TLR3/ISL1/TWIST1 3 GO:0001890 placenta development 4/255 144/18722 0.133979707348434 0.555430987617267 GJA1/ITGB8/BMPR2/PTK2 4 GO:0010821 regulation of mitochondrion organization 4/255 144/18722 0.133979707348434 0.555430987617267 PISD/CLU/PLD6/DNM1L 4 GO:0106106 cold-induced thermogenesis 4/255 144/18722 0.133979707348434 0.555430987617267 GJA1/NR1H3/ACSL1/PRKAB1 4 GO:0120161 regulation of cold-induced thermogenesis 4/255 144/18722 0.133979707348434 0.555430987617267 GJA1/NR1H3/ACSL1/PRKAB1 4 GO:0031099 regeneration 5/255 198/18722 0.134244081302895 0.555430987617267 EYS/GLI3/ISL1/JAM3/ADAM15 5 GO:0001774 microglial cell activation 2/255 47/18722 0.134290187610085 0.555430987617267 TLR3/CLU 2 GO:0032369 negative regulation of lipid transport 2/255 47/18722 0.134290187610085 0.555430987617267 NR1H3/ITGAV 2 GO:0097300 programmed necrotic cell death 2/255 47/18722 0.134290187610085 0.555430987617267 TLR3/DNM1L 2 GO:0101023 vascular endothelial cell proliferation 2/255 47/18722 0.134290187610085 0.555430987617267 SP1/PDPK1 2 GO:1905562 regulation of vascular endothelial cell proliferation 2/255 47/18722 0.134290187610085 0.555430987617267 SP1/PDPK1 2 GO:0070588 calcium ion transmembrane transport 7/255 312/18722 0.135119241649067 0.555430987617267 EHD3/TMC1/CATSPER2/PSEN2/P2RX7/ITGAV/PDPK1 7 GO:0051924 regulation of calcium ion transport 6/255 255/18722 0.136106438527713 0.555430987617267 EHD3/GJA1/TMC1/PSEN2/P2RX7/PDPK1 6 GO:1903362 regulation of cellular protein catabolic process 6/255 255/18722 0.136106438527713 0.555430987617267 LRP2/DISC1/CLU/HSPBP1/PTK2/USP19 6 GO:0014020 primary neural tube formation 3/255 94/18722 0.136823426222006 0.555430987617267 COBL/LRP2/TWIST1 3 GO:0048704 embryonic skeletal system morphogenesis 3/255 94/18722 0.136823426222006 0.555430987617267 GLI3/SIX4/TWIST1 3 GO:1903035 negative regulation of response to wounding 3/255 94/18722 0.136823426222006 0.555430987617267 GJA1/CLDN19/SERPINE1 3 GO:0045216 cell-cell junction organization 5/255 200/18722 0.138326153336647 0.555430987617267 GJA1/CLDN19/SVEP1/JAM3/CTNND1 5 GO:0007043 cell-cell junction assembly 4/255 146/18722 0.138846636437022 0.555430987617267 GJA1/CLDN19/JAM3/CTNND1 4 GO:0042908 xenobiotic transport 2/255 48/18722 0.138931322526261 0.555430987617267 GJA1/ATP8B1 2 GO:0044458 motile cilium assembly 2/255 48/18722 0.138931322526261 0.555430987617267 TTLL1/INTU 2 GO:0090199 regulation of release of cytochrome c from mitochondria 2/255 48/18722 0.138931322526261 0.555430987617267 CLU/DNM1L 2 GO:1902003 regulation of amyloid-beta formation 2/255 48/18722 0.138931322526261 0.555430987617267 CLU/SP1 2 GO:0042391 regulation of membrane potential 9/255 434/18722 0.139815707996078 0.555430987617267 EHD3/GJA1/CLDN19/PPP1R9A/GABRE/CNIH3/MPP2/P2RX7/PIAS3 9 GO:0030516 regulation of axon extension 3/255 95/18722 0.139951084597102 0.555430987617267 SEMA4G/DISC1/BMPR2 3 GO:0042982 amyloid precursor protein metabolic process 3/255 95/18722 0.139951084597102 0.555430987617267 CLU/PSEN2/SP1 3 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/255 11/18722 0.140061155133717 0.555430987617267 TSEN15 1 GO:0003093 regulation of glomerular filtration 1/255 11/18722 0.140061155133717 0.555430987617267 GJA1 1 GO:0003263 cardioblast proliferation 1/255 11/18722 0.140061155133717 0.555430987617267 ISL1 1 GO:0003264 regulation of cardioblast proliferation 1/255 11/18722 0.140061155133717 0.555430987617267 ISL1 1 GO:0007042 lysosomal lumen acidification 1/255 11/18722 0.140061155133717 0.555430987617267 CLN5 1 GO:0009313 oligosaccharide catabolic process 1/255 11/18722 0.140061155133717 0.555430987617267 MANBA 1 GO:0015886 heme transport 1/255 11/18722 0.140061155133717 0.555430987617267 FLVCR2 1 GO:0018026 peptidyl-lysine monomethylation 1/255 11/18722 0.140061155133717 0.555430987617267 SETD6 1 GO:0019048 modulation by virus of host process 1/255 11/18722 0.140061155133717 0.555430987617267 ATG7 1 GO:0021561 facial nerve development 1/255 11/18722 0.140061155133717 0.555430987617267 NRP2 1 GO:0021604 cranial nerve structural organization 1/255 11/18722 0.140061155133717 0.555430987617267 NRP2 1 GO:0021610 facial nerve morphogenesis 1/255 11/18722 0.140061155133717 0.555430987617267 NRP2 1 GO:0021702 cerebellar Purkinje cell differentiation 1/255 11/18722 0.140061155133717 0.555430987617267 TTLL1 1 GO:0021860 pyramidal neuron development 1/255 11/18722 0.140061155133717 0.555430987617267 DISC1 1 GO:0032276 regulation of gonadotropin secretion 1/255 11/18722 0.140061155133717 0.555430987617267 GJA1 1 GO:0032329 serine transport 1/255 11/18722 0.140061155133717 0.555430987617267 SLC38A5 1 GO:0032610 interleukin-1 alpha production 1/255 11/18722 0.140061155133717 0.555430987617267 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/255 11/18722 0.140061155133717 0.555430987617267 ISL1 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/255 11/18722 0.140061155133717 0.555430987617267 CXCR2 1 GO:0033234 negative regulation of protein sumoylation 1/255 11/18722 0.140061155133717 0.555430987617267 PIAS3 1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1/255 11/18722 0.140061155133717 0.555430987617267 ACADS 1 GO:0033690 positive regulation of osteoblast proliferation 1/255 11/18722 0.140061155133717 0.555430987617267 ITGAV 1 GO:0034969 histone arginine methylation 1/255 11/18722 0.140061155133717 0.555430987617267 PRMT7 1 GO:0035246 peptidyl-arginine N-methylation 1/255 11/18722 0.140061155133717 0.555430987617267 PRMT7 1 GO:0043589 skin morphogenesis 1/255 11/18722 0.140061155133717 0.555430987617267 ITGB4 1 GO:0044068 modulation by symbiont of host cellular process 1/255 11/18722 0.140061155133717 0.555430987617267 ATG7 1 GO:0045060 negative thymic T cell selection 1/255 11/18722 0.140061155133717 0.555430987617267 GLI3 1 GO:0046929 negative regulation of neurotransmitter secretion 1/255 11/18722 0.140061155133717 0.555430987617267 PPP1R9A 1 GO:0048102 autophagic cell death 1/255 11/18722 0.140061155133717 0.555430987617267 ATG7 1 GO:0060379 cardiac muscle cell myoblast differentiation 1/255 11/18722 0.140061155133717 0.555430987617267 ISL1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/255 11/18722 0.140061155133717 0.555430987617267 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/255 11/18722 0.140061155133717 0.555430987617267 GLI3 1 GO:0060900 embryonic camera-type eye formation 1/255 11/18722 0.140061155133717 0.555430987617267 TWIST1 1 GO:0061029 eyelid development in camera-type eye 1/255 11/18722 0.140061155133717 0.555430987617267 TWIST1 1 GO:0061365 positive regulation of triglyceride lipase activity 1/255 11/18722 0.140061155133717 0.555430987617267 NR1H3 1 GO:0072173 metanephric tubule morphogenesis 1/255 11/18722 0.140061155133717 0.555430987617267 CXCR2 1 GO:0090160 Golgi to lysosome transport 1/255 11/18722 0.140061155133717 0.555430987617267 EHD3 1 GO:0090649 response to oxygen-glucose deprivation 1/255 11/18722 0.140061155133717 0.555430987617267 DNM1L 1 GO:1903423 positive regulation of synaptic vesicle recycling 1/255 11/18722 0.140061155133717 0.555430987617267 DNM1L 1 GO:2000392 regulation of lamellipodium morphogenesis 1/255 11/18722 0.140061155133717 0.555430987617267 KANK1 1 GO:1903531 negative regulation of secretion by cell 4/255 147/18722 0.141306531643216 0.555430987617267 GJA1/NR1H3/PPP1R9A/IRS1 4 GO:0017157 regulation of exocytosis 5/255 202/18722 0.142462576890047 0.555430987617267 SYT1/RAB15/SYT8/PDPK1/DNM1L 5 GO:0019722 calcium-mediated signaling 5/255 202/18722 0.142462576890047 0.555430987617267 CXCR2/PPP1R9A/LMCD1/P2RX7/PDPK1 5 GO:0003073 regulation of systemic arterial blood pressure 3/255 96/18722 0.143102781175272 0.555430987617267 GJA1/ENPEP/BMPR2 3 GO:0035282 segmentation 3/255 96/18722 0.143102781175272 0.555430987617267 COBL/NRP2/PLD6 3 GO:0042158 lipoprotein biosynthetic process 3/255 96/18722 0.143102781175272 0.555430987617267 ATG7/ABCA1/ZDHHC13 3 GO:0000959 mitochondrial RNA metabolic process 2/255 49/18722 0.143606987886408 0.555430987617267 YARS2/TRMT61B 2 GO:0008206 bile acid metabolic process 2/255 49/18722 0.143606987886408 0.555430987617267 ATP8B1/STARD4 2 GO:0010823 negative regulation of mitochondrion organization 2/255 49/18722 0.143606987886408 0.555430987617267 CLU/DNM1L 2 GO:0021515 cell differentiation in spinal cord 2/255 49/18722 0.143606987886408 0.555430987617267 GLI3/ISL1 2 GO:0021695 cerebellar cortex development 2/255 49/18722 0.143606987886408 0.555430987617267 NAGLU/TTLL1 2 GO:0043330 response to exogenous dsRNA 2/255 49/18722 0.143606987886408 0.555430987617267 TLR3/ZCCHC3 2 GO:0051932 synaptic transmission, GABAergic 2/255 49/18722 0.143606987886408 0.555430987617267 GABRE/CLSTN3 2 GO:0070849 response to epidermal growth factor 2/255 49/18722 0.143606987886408 0.555430987617267 GAREM1/PDPK1 2 GO:0035148 tube formation 4/255 148/18722 0.143783742127913 0.555430987617267 COBL/SIX4/LRP2/TWIST1 4 GO:0060541 respiratory system development 5/255 203/18722 0.144550864482192 0.555430987617267 LAMA5/GLI3/SIX4/ITGA3/BMPR2 5 GO:0018212 peptidyl-tyrosine modification 8/255 378/18722 0.145815514477489 0.555430987617267 EFNA5/BTC/MET/DDR1/ISL1/WEE1/PTK2/TPST2 8 GO:0014909 smooth muscle cell migration 3/255 97/18722 0.146277987076553 0.555430987617267 DDR1/PARVA/SERPINE1 3 GO:0120162 positive regulation of cold-induced thermogenesis 3/255 97/18722 0.146277987076553 0.555430987617267 GJA1/ACSL1/PRKAB1 3 GO:0016525 negative regulation of angiogenesis 4/255 149/18722 0.14627803682285 0.555430987617267 COL4A2/EPN2/SERPINE1/PTPRM 4 GO:1905039 carboxylic acid transmembrane transport 4/255 149/18722 0.14627803682285 0.555430987617267 LRP2/SLC19A1/ACSL1/SLC38A5 4 GO:1901214 regulation of neuron death 7/255 319/18722 0.146478451924339 0.555430987617267 SNCG/PAK3/ISL1/SIX4/CLU/ATG7/PDPK1 7 GO:0050878 regulation of body fluid levels 8/255 379/18722 0.147326890792328 0.555430987617267 GJA1/BTC/MYO5B/NR1H3/MET/DDR1/SERPINE1/F5 8 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/255 50/18722 0.148315392669563 0.555430987617267 CXCR2/PDPK1 2 GO:0046460 neutral lipid biosynthetic process 2/255 50/18722 0.148315392669563 0.555430987617267 NR1H3/ACSL1 2 GO:0046463 acylglycerol biosynthetic process 2/255 50/18722 0.148315392669563 0.555430987617267 NR1H3/ACSL1 2 GO:0051646 mitochondrion localization 2/255 50/18722 0.148315392669563 0.555430987617267 CLUH/DNM1L 2 GO:1904036 negative regulation of epithelial cell apoptotic process 2/255 50/18722 0.148315392669563 0.555430987617267 SERPINE1/PDPK1 2 GO:1903825 organic acid transmembrane transport 4/255 150/18722 0.148789183008208 0.555430987617267 LRP2/SLC19A1/ACSL1/SLC38A5 4 GO:0061337 cardiac conduction 3/255 98/18722 0.149476173796919 0.555430987617267 EHD3/GJA1/ISL1 3 GO:2000181 negative regulation of blood vessel morphogenesis 4/255 151/18722 0.151316946399112 0.555430987617267 COL4A2/EPN2/SERPINE1/PTPRM 4 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 1/255 12/18722 0.151780700077382 0.555430987617267 BHLHE40-AS1 1 GO:0009886 post-embryonic animal morphogenesis 1/255 12/18722 0.151780700077382 0.555430987617267 FBN1 1 GO:0021559 trigeminal nerve development 1/255 12/18722 0.151780700077382 0.555430987617267 ISL1 1 GO:0030157 pancreatic juice secretion 1/255 12/18722 0.151780700077382 0.555430987617267 NR1H3 1 GO:0030238 male sex determination 1/255 12/18722 0.151780700077382 0.555430987617267 SIX4 1 GO:0030259 lipid glycosylation 1/255 12/18722 0.151780700077382 0.555430987617267 GBGT1 1 GO:0033127 regulation of histone phosphorylation 1/255 12/18722 0.151780700077382 0.555430987617267 TWIST1 1 GO:0033235 positive regulation of protein sumoylation 1/255 12/18722 0.151780700077382 0.555430987617267 PIAS3 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/255 12/18722 0.151780700077382 0.555430987617267 NR1H3 1 GO:0034333 adherens junction assembly 1/255 12/18722 0.151780700077382 0.555430987617267 JAM3 1 GO:0042117 monocyte activation 1/255 12/18722 0.151780700077382 0.555430987617267 ADAM9 1 GO:0042762 regulation of sulfur metabolic process 1/255 12/18722 0.151780700077382 0.555430987617267 SP1 1 GO:0043383 negative T cell selection 1/255 12/18722 0.151780700077382 0.555430987617267 GLI3 1 GO:0045039 protein insertion into mitochondrial inner membrane 1/255 12/18722 0.151780700077382 0.555430987617267 TIMM8A 1 GO:0048548 regulation of pinocytosis 1/255 12/18722 0.151780700077382 0.555430987617267 NR1H3 1 GO:0048934 peripheral nervous system neuron differentiation 1/255 12/18722 0.151780700077382 0.555430987617267 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/255 12/18722 0.151780700077382 0.555430987617267 ISL1 1 GO:0051013 microtubule severing 1/255 12/18722 0.151780700077382 0.555430987617267 KATNB1 1 GO:0051639 actin filament network formation 1/255 12/18722 0.151780700077382 0.555430987617267 COBL 1 GO:0060221 retinal rod cell differentiation 1/255 12/18722 0.151780700077382 0.555430987617267 NAGLU 1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry 1/255 12/18722 0.151780700077382 0.555430987617267 CFAP53 1 GO:0060788 ectodermal placode formation 1/255 12/18722 0.151780700077382 0.555430987617267 SIX4 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/255 12/18722 0.151780700077382 0.555430987617267 GLI3 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/255 12/18722 0.151780700077382 0.555430987617267 TWIST1 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/255 12/18722 0.151780700077382 0.555430987617267 TWIST1 1 GO:0061430 bone trabecula morphogenesis 1/255 12/18722 0.151780700077382 0.555430987617267 FBN2 1 GO:0070170 regulation of tooth mineralization 1/255 12/18722 0.151780700077382 0.555430987617267 SLC4A2 1 GO:0070493 thrombin-activated receptor signaling pathway 1/255 12/18722 0.151780700077382 0.555430987617267 MET 1 GO:0070857 regulation of bile acid biosynthetic process 1/255 12/18722 0.151780700077382 0.555430987617267 STARD4 1 GO:0071107 response to parathyroid hormone 1/255 12/18722 0.151780700077382 0.555430987617267 GJA1 1 GO:0071697 ectodermal placode morphogenesis 1/255 12/18722 0.151780700077382 0.555430987617267 SIX4 1 GO:0072711 cellular response to hydroxyurea 1/255 12/18722 0.151780700077382 0.555430987617267 DDX11 1 GO:0090646 mitochondrial tRNA processing 1/255 12/18722 0.151780700077382 0.555430987617267 TRMT61B 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/255 12/18722 0.151780700077382 0.555430987617267 PPP1R9A 1 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 1/255 12/18722 0.151780700077382 0.555430987617267 MET 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/255 12/18722 0.151780700077382 0.555430987617267 PLXND1 1 GO:2000303 regulation of ceramide biosynthetic process 1/255 12/18722 0.151780700077382 0.555430987617267 SIRT3 1 GO:2000344 positive regulation of acrosome reaction 1/255 12/18722 0.151780700077382 0.555430987617267 PLB1 1 GO:2001204 regulation of osteoclast development 1/255 12/18722 0.151780700077382 0.555430987617267 FBN1 1 GO:1902903 regulation of supramolecular fiber organization 8/255 382/18722 0.151907101069054 0.555430987617267 KANK4/PPP1R9A/PAK3/MET/ARHGAP28/CLU/KANK1/KATNB1 8 GO:0032868 response to insulin 6/255 264/18722 0.152580193368474 0.555430987617267 BCAR1/IRS1/KANK1/RAB15/SP1/PDPK1 6 GO:0015837 amine transport 3/255 99/18722 0.152696813422875 0.555430987617267 SYT1/SNCG/SYT8 3 GO:0021510 spinal cord development 3/255 99/18722 0.152696813422875 0.555430987617267 GLI3/ISL1/INTU 3 GO:0010874 regulation of cholesterol efflux 2/255 51/18722 0.15305478788432 0.555430987617267 NR1H3/ABCA1 2 GO:0045668 negative regulation of osteoblast differentiation 2/255 51/18722 0.15305478788432 0.555430987617267 CRIM1/TWIST1 2 GO:0046850 regulation of bone remodeling 2/255 51/18722 0.15305478788432 0.555430987617267 P2RX7/CA2 2 GO:0050982 detection of mechanical stimulus 2/255 51/18722 0.15305478788432 0.555430987617267 TMC1/PTK2 2 GO:1901343 negative regulation of vasculature development 4/255 152/18722 0.153861091230971 0.555430987617267 COL4A2/EPN2/SERPINE1/PTPRM 4 GO:0002573 myeloid leukocyte differentiation 5/255 208/18722 0.155188024988506 0.555430987617267 TLR3/FBN1/ITGB8/PIAS3/CA2 5 GO:0006836 neurotransmitter transport 5/255 208/18722 0.155188024988506 0.555430987617267 SYT1/SNCG/PPP1R9A/SYT8/DNM1L 5 GO:0006664 glycolipid metabolic process 3/255 100/18722 0.15593937883848 0.555430987617267 ST3GAL6/ITGB8/GBGT1 3 GO:0009062 fatty acid catabolic process 3/255 100/18722 0.15593937883848 0.555430987617267 ACADS/IRS1/TWIST1 3 GO:0044728 DNA methylation or demethylation 3/255 100/18722 0.15593937883848 0.555430987617267 N6AMT1/PRMT7/PLD6 3 GO:0045807 positive regulation of endocytosis 3/255 100/18722 0.15593937883848 0.555430987617267 CLU/SERPINE1/DNM1L 3 GO:0060079 excitatory postsynaptic potential 3/255 100/18722 0.15593937883848 0.555430987617267 PPP1R9A/MPP2/P2RX7 3 GO:0110020 regulation of actomyosin structure organization 3/255 100/18722 0.15593937883848 0.555430987617267 PPP1R9A/MET/ARHGAP28 3 GO:0002218 activation of innate immune response 2/255 52/18722 0.157823465763742 0.555430987617267 PAK3/ZCCHC3 2 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 2/255 52/18722 0.157823465763742 0.555430987617267 KDELR3/PLPP3 2 GO:0010662 regulation of striated muscle cell apoptotic process 2/255 52/18722 0.157823465763742 0.555430987617267 CXCR2/PDPK1 2 GO:0010718 positive regulation of epithelial to mesenchymal transition 2/255 52/18722 0.157823465763742 0.555430987617267 ISL1/TWIST1 2 GO:0031103 axon regeneration 2/255 52/18722 0.157823465763742 0.555430987617267 ISL1/JAM3 2 GO:0043277 apoptotic cell clearance 2/255 52/18722 0.157823465763742 0.555430987617267 NR1H3/ITGAV 2 GO:0048260 positive regulation of receptor-mediated endocytosis 2/255 52/18722 0.157823465763742 0.555430987617267 CLU/SERPINE1 2 GO:0072132 mesenchyme morphogenesis 2/255 52/18722 0.157823465763742 0.555430987617267 ISL1/TWIST1 2 GO:0050727 regulation of inflammatory response 8/255 386/18722 0.158120136626076 0.555430987617267 TLR3/NR1H3/S100A8/ISL1/SHPK/FANCA/SERPINE1/SETD6 8 GO:0008360 regulation of cell shape 4/255 154/18722 0.158997575264527 0.555430987617267 PARVA/FMNL2/PLXND1/PTK2 4 GO:0051963 regulation of synapse assembly 3/255 101/18722 0.159203343925016 0.555430987617267 PPP1R9A/SIX4/CLSTN3 3 GO:1903509 liposaccharide metabolic process 3/255 101/18722 0.159203343925016 0.555430987617267 ST3GAL6/ITGB8/GBGT1 3 GO:0002685 regulation of leukocyte migration 5/255 210/18722 0.159531815470725 0.555430987617267 CXCR2/JAM3/SERPINE1/PTK2/DNM1L 5 GO:0001894 tissue homeostasis 6/255 268/18722 0.160175757408255 0.555430987617267 POTEI/GJA1/PBLD/JAM3/P2RX7/CA2 6 GO:0006665 sphingolipid metabolic process 4/255 155/18722 0.161589436290221 0.555430987617267 ASAH2B/PLPP3/ITGB8/SIRT3 4 GO:0030100 regulation of endocytosis 5/255 211/18722 0.161722238693298 0.555430987617267 NR1H3/CLU/SERPINE1/ITGAV/DNM1L 5 GO:0001841 neural tube formation 3/255 102/18722 0.162488183753478 0.555430987617267 COBL/LRP2/TWIST1 3 GO:0008347 glial cell migration 2/255 53/18722 0.162619758974279 0.555430987617267 GLI3/DISC1 2 GO:0045806 negative regulation of endocytosis 2/255 53/18722 0.162619758974279 0.555430987617267 NR1H3/ITGAV 2 GO:1903202 negative regulation of oxidative stress-induced cell death 2/255 53/18722 0.162619758974279 0.555430987617267 MET/ATG7 2 GO:0001886 endothelial cell morphogenesis 1/255 13/18722 0.163341144838486 0.555430987617267 MET 1 GO:0005513 detection of calcium ion 1/255 13/18722 0.163341144838486 0.555430987617267 SYT1 1 GO:0006264 mitochondrial DNA replication 1/255 13/18722 0.163341144838486 0.555430987617267 ATG7 1 GO:0006995 cellular response to nitrogen starvation 1/255 13/18722 0.163341144838486 0.555430987617267 ATG7 1 GO:0010755 regulation of plasminogen activation 1/255 13/18722 0.163341144838486 0.555430987617267 SERPINE1 1 GO:0015801 aromatic amino acid transport 1/255 13/18722 0.163341144838486 0.555430987617267 SLC38A5 1 GO:0015816 glycine transport 1/255 13/18722 0.163341144838486 0.555430987617267 SLC38A5 1 GO:0018095 protein polyglutamylation 1/255 13/18722 0.163341144838486 0.555430987617267 TTLL1 1 GO:0019755 one-carbon compound transport 1/255 13/18722 0.163341144838486 0.555430987617267 CA2 1 GO:0021514 ventral spinal cord interneuron differentiation 1/255 13/18722 0.163341144838486 0.555430987617267 GLI3 1 GO:0021554 optic nerve development 1/255 13/18722 0.163341144838486 0.555430987617267 GLI3 1 GO:0021694 cerebellar Purkinje cell layer formation 1/255 13/18722 0.163341144838486 0.555430987617267 TTLL1 1 GO:0021819 layer formation in cerebral cortex 1/255 13/18722 0.163341144838486 0.555430987617267 GLI3 1 GO:0021859 pyramidal neuron differentiation 1/255 13/18722 0.163341144838486 0.555430987617267 DISC1 1 GO:0032530 regulation of microvillus organization 1/255 13/18722 0.163341144838486 0.555430987617267 ATP8B1 1 GO:0033700 phospholipid efflux 1/255 13/18722 0.163341144838486 0.555430987617267 ABCA1 1 GO:0042308 negative regulation of protein import into nucleus 1/255 13/18722 0.163341144838486 0.555430987617267 RAB23 1 GO:0043562 cellular response to nitrogen levels 1/255 13/18722 0.163341144838486 0.555430987617267 ATG7 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/255 13/18722 0.163341144838486 0.555430987617267 BTC 1 GO:0046512 sphingosine biosynthetic process 1/255 13/18722 0.163341144838486 0.555430987617267 ASAH2B 1 GO:0046520 sphingoid biosynthetic process 1/255 13/18722 0.163341144838486 0.555430987617267 ASAH2B 1 GO:0051451 myoblast migration 1/255 13/18722 0.163341144838486 0.555430987617267 SIX4 1 GO:0051709 regulation of killing of cells of other organism 1/255 13/18722 0.163341144838486 0.555430987617267 P2RX7 1 GO:0070486 leukocyte aggregation 1/255 13/18722 0.163341144838486 0.555430987617267 S100A8 1 GO:0071696 ectodermal placode development 1/255 13/18722 0.163341144838486 0.555430987617267 SIX4 1 GO:0072710 response to hydroxyurea 1/255 13/18722 0.163341144838486 0.555430987617267 DDX11 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/255 13/18722 0.163341144838486 0.555430987617267 SIRT3 1 GO:1900121 negative regulation of receptor binding 1/255 13/18722 0.163341144838486 0.555430987617267 ADAM15 1 GO:1900272 negative regulation of long-term synaptic potentiation 1/255 13/18722 0.163341144838486 0.555430987617267 PPP1R9A 1 GO:1900452 regulation of long-term synaptic depression 1/255 13/18722 0.163341144838486 0.555430987617267 PPP1R9A 1 GO:1901387 positive regulation of voltage-gated calcium channel activity 1/255 13/18722 0.163341144838486 0.555430987617267 EHD3 1 GO:1902947 regulation of tau-protein kinase activity 1/255 13/18722 0.163341144838486 0.555430987617267 CLU 1 GO:1904590 negative regulation of protein import 1/255 13/18722 0.163341144838486 0.555430987617267 RAB23 1 GO:1905038 regulation of membrane lipid metabolic process 1/255 13/18722 0.163341144838486 0.555430987617267 SIRT3 1 GO:1905907 negative regulation of amyloid fibril formation 1/255 13/18722 0.163341144838486 0.555430987617267 CLU 1 GO:0019395 fatty acid oxidation 3/255 103/18722 0.16579337477005 0.560832127004425 ACADS/IRS1/TWIST1 3 GO:0030004 cellular monovalent inorganic cation homeostasis 3/255 103/18722 0.16579337477005 0.560832127004425 SLC4A2/CLN5/CA2 3 GO:0030148 sphingolipid biosynthetic process 3/255 103/18722 0.16579337477005 0.560832127004425 ASAH2B/PLPP3/SIRT3 3 GO:0090277 positive regulation of peptide hormone secretion 3/255 103/18722 0.16579337477005 0.560832127004425 GJA1/ISL1/SIRT3 3 GO:0040013 negative regulation of locomotion 8/255 391/18722 0.166053313934485 0.560832127004425 SEMA4G/GJA1/CLDN19/SRGAP3/KANK1/SERPINE1/ADAM15/PTPRM 8 GO:0001505 regulation of neurotransmitter levels 5/255 213/18722 0.166139467227457 0.560832127004425 SYT1/SNCG/PPP1R9A/SYT8/DNM1L 5 GO:1990845 adaptive thermogenesis 4/255 157/18722 0.166819192171927 0.560832127004425 GJA1/NR1H3/ACSL1/PRKAB1 4 GO:0019216 regulation of lipid metabolic process 7/255 331/18722 0.166963095308045 0.560832127004425 NR1H3/IRS1/TWIST1/STARD4/IDH1/SIRT3/PTK2 7 GO:0001706 endoderm formation 2/255 54/18722 0.167442039838441 0.560832127004425 COL4A2/ITGAV 2 GO:0006968 cellular defense response 2/255 54/18722 0.167442039838441 0.560832127004425 CXCR2/RAB23 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/255 54/18722 0.167442039838441 0.560832127004425 P2RX7/PDPK1 2 GO:0010659 cardiac muscle cell apoptotic process 2/255 54/18722 0.167442039838441 0.560832127004425 CXCR2/PDPK1 2 GO:0035065 regulation of histone acetylation 2/255 54/18722 0.167442039838441 0.560832127004425 ISL1/TWIST1 2 GO:2000300 regulation of synaptic vesicle exocytosis 2/255 54/18722 0.167442039838441 0.560832127004425 SYT1/DNM1L 2 GO:0044242 cellular lipid catabolic process 5/255 214/18722 0.168365999793118 0.562386202733757 ASAH2B/ACADS/IRS1/TWIST1/IDH1 5 GO:1903169 regulation of calcium ion transmembrane transport 4/255 159/18722 0.172108708783053 0.562386202733757 EHD3/TMC1/PSEN2/PDPK1 4 GO:0003179 heart valve morphogenesis 2/255 55/18722 0.172288719571019 0.562386202733757 TWIST1/BMPR2 2 GO:0003229 ventricular cardiac muscle tissue development 2/255 55/18722 0.172288719571019 0.562386202733757 ISL1/LRP2 2 GO:0043331 response to dsRNA 2/255 55/18722 0.172288719571019 0.562386202733757 TLR3/ZCCHC3 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/255 55/18722 0.172288719571019 0.562386202733757 CLU/SP1 2 GO:0016079 synaptic vesicle exocytosis 3/255 105/18722 0.172462724093476 0.562386202733757 SYT1/SYT8/DNM1L 3 GO:0032231 regulation of actin filament bundle assembly 3/255 105/18722 0.172462724093476 0.562386202733757 PPP1R9A/MET/ARHGAP28 3 GO:0032970 regulation of actin filament-based process 8/255 396/18722 0.174166971042506 0.562386202733757 EFNA5/KANK4/PPP1R9A/PAK3/MET/JAM3/ARHGAP28/KANK1 8 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1/255 14/18722 0.174744640913433 0.562386202733757 TLR3 1 GO:0003188 heart valve formation 1/255 14/18722 0.174744640913433 0.562386202733757 TWIST1 1 GO:0006241 CTP biosynthetic process 1/255 14/18722 0.174744640913433 0.562386202733757 CTPS2 1 GO:0006465 signal peptide processing 1/255 14/18722 0.174744640913433 0.562386202733757 CLN5 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/255 14/18722 0.174744640913433 0.562386202733757 EFNA5 1 GO:0009214 cyclic nucleotide catabolic process 1/255 14/18722 0.174744640913433 0.562386202733757 PDE10A 1 GO:0010421 hydrogen peroxide-mediated programmed cell death 1/255 14/18722 0.174744640913433 0.562386202733757 MET 1 GO:0010839 negative regulation of keratinocyte proliferation 1/255 14/18722 0.174744640913433 0.562386202733757 INTU 1 GO:0010867 positive regulation of triglyceride biosynthetic process 1/255 14/18722 0.174744640913433 0.562386202733757 NR1H3 1 GO:0010872 regulation of cholesterol esterification 1/255 14/18722 0.174744640913433 0.562386202733757 STARD4 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/255 14/18722 0.174744640913433 0.562386202733757 EPN2 1 GO:0033605 positive regulation of catecholamine secretion 1/255 14/18722 0.174744640913433 0.562386202733757 SYT1 1 GO:0035810 positive regulation of urine volume 1/255 14/18722 0.174744640913433 0.562386202733757 BTC 1 GO:0036295 cellular response to increased oxygen levels 1/255 14/18722 0.174744640913433 0.562386202733757 ATG7 1 GO:0036444 calcium import into the mitochondrion 1/255 14/18722 0.174744640913433 0.562386202733757 PSEN2 1 GO:0038166 angiotensin-activated signaling pathway 1/255 14/18722 0.174744640913433 0.562386202733757 CA2 1 GO:0046655 folic acid metabolic process 1/255 14/18722 0.174744640913433 0.562386202733757 SLC19A1 1 GO:0051589 negative regulation of neurotransmitter transport 1/255 14/18722 0.174744640913433 0.562386202733757 PPP1R9A 1 GO:0051917 regulation of fibrinolysis 1/255 14/18722 0.174744640913433 0.562386202733757 SERPINE1 1 GO:0055057 neuroblast division 1/255 14/18722 0.174744640913433 0.562386202733757 TEAD3 1 GO:0060841 venous blood vessel development 1/255 14/18722 0.174744640913433 0.562386202733757 BMPR2 1 GO:0060911 cardiac cell fate commitment 1/255 14/18722 0.174744640913433 0.562386202733757 ISL1 1 GO:0061043 regulation of vascular wound healing 1/255 14/18722 0.174744640913433 0.562386202733757 SERPINE1 1 GO:0072350 tricarboxylic acid metabolic process 1/255 14/18722 0.174744640913433 0.562386202733757 IDH1 1 GO:0072531 pyrimidine-containing compound transmembrane transport 1/255 14/18722 0.174744640913433 0.562386202733757 SLC19A2 1 GO:0090128 regulation of synapse maturation 1/255 14/18722 0.174744640913433 0.562386202733757 DISC1 1 GO:0099188 postsynaptic cytoskeleton organization 1/255 14/18722 0.174744640913433 0.562386202733757 PPP1R9A 1 GO:1900037 regulation of cellular response to hypoxia 1/255 14/18722 0.174744640913433 0.562386202733757 USP19 1 GO:1901678 iron coordination entity transport 1/255 14/18722 0.174744640913433 0.562386202733757 FLVCR2 1 GO:0030038 contractile actin filament bundle assembly 3/255 106/18722 0.175825843743409 0.56275046503671 PPP1R9A/MET/ARHGAP28 3 GO:0035821 modulation of process of other organism 3/255 106/18722 0.175825843743409 0.56275046503671 ATG7/P2RX7/SP1 3 GO:0043149 stress fiber assembly 3/255 106/18722 0.175825843743409 0.56275046503671 PPP1R9A/MET/ARHGAP28 3 GO:0099565 chemical synaptic transmission, postsynaptic 3/255 106/18722 0.175825843743409 0.56275046503671 PPP1R9A/MPP2/P2RX7 3 GO:2000278 regulation of DNA biosynthetic process 3/255 106/18722 0.175825843743409 0.56275046503671 GJA1/PAK3/BMPR2 3 GO:0010658 striated muscle cell apoptotic process 2/255 56/18722 0.177158247528617 0.56275046503671 CXCR2/PDPK1 2 GO:0022029 telencephalon cell migration 2/255 56/18722 0.177158247528617 0.56275046503671 GLI3/DISC1 2 GO:0030166 proteoglycan biosynthetic process 2/255 56/18722 0.177158247528617 0.56275046503671 CHST3/BMPR2 2 GO:0043388 positive regulation of DNA binding 2/255 56/18722 0.177158247528617 0.56275046503671 ISL1/TWIST1 2 GO:0110053 regulation of actin filament organization 6/255 277/18722 0.1778465047671 0.56275046503671 KANK4/PPP1R9A/PAK3/MET/ARHGAP28/KANK1 6 GO:0006275 regulation of DNA replication 3/255 107/18722 0.179207237592292 0.56275046503671 CDAN1/ATG7/GMNN 3 GO:0010927 cellular component assembly involved in morphogenesis 3/255 107/18722 0.179207237592292 0.56275046503671 TNNT3/SIX4/ITGB4 3 GO:0097191 extrinsic apoptotic signaling pathway 5/255 219/18722 0.17967230184419 0.56275046503671 TLR3/SERPINE1/P2RX7/ITGAV/PDPK1 5 GO:0031349 positive regulation of defense response 6/255 278/18722 0.179857508427843 0.56275046503671 TLR3/GJA1/S100A8/PAK3/ZCCHC3/SERPINE1 6 GO:1902105 regulation of leukocyte differentiation 6/255 279/18722 0.181877697215685 0.56275046503671 TLR3/FBN1/GLI3/FANCA/PIAS3/CA2 6 GO:0002011 morphogenesis of an epithelial sheet 2/255 57/18722 0.18204911047229 0.56275046503671 DDR1/ARHGAP24 2 GO:0050891 multicellular organismal water homeostasis 2/255 57/18722 0.18204911047229 0.56275046503671 MYO5B/MET 2 GO:0060042 retina morphogenesis in camera-type eye 2/255 57/18722 0.18204911047229 0.56275046503671 NAGLU/PTPRM 2 GO:0034440 lipid oxidation 3/255 108/18722 0.182606391511397 0.56275046503671 ACADS/IRS1/TWIST1 3 GO:0140053 mitochondrial gene expression 3/255 108/18722 0.182606391511397 0.56275046503671 YARS2/TRMT61B/MRPS28 3 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 5/255 221/18722 0.184273224749457 0.56275046503671 DISC1/CLU/HSPBP1/PTK2/USP19 5 GO:0050680 negative regulation of epithelial cell proliferation 4/255 164/18722 0.185581101745817 0.56275046503671 GJA1/ISL1/INTU/PTPRM 4 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 4/255 164/18722 0.185581101745817 0.56275046503671 DISC1/CLU/HSPBP1/PTK2 4 GO:0002730 regulation of dendritic cell cytokine production 1/255 15/18722 0.185993310817596 0.56275046503671 TLR3 1 GO:0006098 pentose-phosphate shunt 1/255 15/18722 0.185993310817596 0.56275046503671 SHPK 1 GO:0007000 nucleolus organization 1/255 15/18722 0.185993310817596 0.56275046503671 DDX11 1 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 1/255 15/18722 0.185993310817596 0.56275046503671 CTPS2 1 GO:0010752 regulation of cGMP-mediated signaling 1/255 15/18722 0.185993310817596 0.56275046503671 PDE10A 1 GO:0010832 negative regulation of myotube differentiation 1/255 15/18722 0.185993310817596 0.56275046503671 BHLHE41 1 GO:0018216 peptidyl-arginine methylation 1/255 15/18722 0.185993310817596 0.56275046503671 PRMT7 1 GO:0018410 C-terminal protein amino acid modification 1/255 15/18722 0.185993310817596 0.56275046503671 ATG7 1 GO:0019511 peptidyl-proline hydroxylation 1/255 15/18722 0.185993310817596 0.56275046503671 P3H2 1 GO:0023035 CD40 signaling pathway 1/255 15/18722 0.185993310817596 0.56275046503671 FANCA 1 GO:0032328 alanine transport 1/255 15/18722 0.185993310817596 0.56275046503671 SLC38A5 1 GO:0032488 Cdc42 protein signal transduction 1/255 15/18722 0.185993310817596 0.56275046503671 ABCA1 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/255 15/18722 0.185993310817596 0.56275046503671 ISL1 1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/255 15/18722 0.185993310817596 0.56275046503671 ISL1 1 GO:0033599 regulation of mammary gland epithelial cell proliferation 1/255 15/18722 0.185993310817596 0.56275046503671 KDM5B 1 GO:0034380 high-density lipoprotein particle assembly 1/255 15/18722 0.185993310817596 0.56275046503671 ABCA1 1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 1/255 15/18722 0.185993310817596 0.56275046503671 TWIST1 1 GO:0035627 ceramide transport 1/255 15/18722 0.185993310817596 0.56275046503671 PLEKHA8 1 GO:0042559 pteridine-containing compound biosynthetic process 1/255 15/18722 0.185993310817596 0.56275046503671 SPR 1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 1/255 15/18722 0.185993310817596 0.56275046503671 TWIST1 1 GO:0045475 locomotor rhythm 1/255 15/18722 0.185993310817596 0.56275046503671 NAGLU 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/255 15/18722 0.185993310817596 0.56275046503671 IRS1 1 GO:0046459 short-chain fatty acid metabolic process 1/255 15/18722 0.185993310817596 0.56275046503671 ACADS 1 GO:0048569 post-embryonic animal organ development 1/255 15/18722 0.185993310817596 0.56275046503671 FBN1 1 GO:0050746 regulation of lipoprotein metabolic process 1/255 15/18722 0.185993310817596 0.56275046503671 ITGAV 1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound 1/255 15/18722 0.185993310817596 0.56275046503671 TMC1 1 GO:0055091 phospholipid homeostasis 1/255 15/18722 0.185993310817596 0.56275046503671 ABCA1 1 GO:0060046 regulation of acrosome reaction 1/255 15/18722 0.185993310817596 0.56275046503671 PLB1 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/255 15/18722 0.185993310817596 0.56275046503671 LMCD1 1 GO:0072075 metanephric mesenchyme development 1/255 15/18722 0.185993310817596 0.56275046503671 SIX4 1 GO:0097468 programmed cell death in response to reactive oxygen species 1/255 15/18722 0.185993310817596 0.56275046503671 MET 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/255 15/18722 0.185993310817596 0.56275046503671 LMCD1 1 GO:1900029 positive regulation of ruffle assembly 1/255 15/18722 0.185993310817596 0.56275046503671 COBL 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/255 15/18722 0.185993310817596 0.56275046503671 DDX11 1 GO:1903729 regulation of plasma membrane organization 1/255 15/18722 0.185993310817596 0.56275046503671 ATP8B1 1 GO:1904251 regulation of bile acid metabolic process 1/255 15/18722 0.185993310817596 0.56275046503671 STARD4 1 GO:1905146 lysosomal protein catabolic process 1/255 15/18722 0.185993310817596 0.56275046503671 LRP2 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/255 15/18722 0.185993310817596 0.56275046503671 MET 1 GO:0006821 chloride transport 3/255 109/18722 0.186022793722535 0.56275046503671 ATP8B1/GABRE/SLC26A2 3 GO:0002931 response to ischemia 2/255 58/18722 0.186959831843054 0.563403543403611 GJA1/P2RX7 2 GO:0010043 response to zinc ion 2/255 58/18722 0.186959831843054 0.563403543403611 S100A8/CA2 2 GO:0032481 positive regulation of type I interferon production 2/255 58/18722 0.186959831843054 0.563403543403611 TLR3/ZCCHC3 2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 2/255 58/18722 0.186959831843054 0.563403543403611 S100A8/DNM1L 2 GO:0007286 spermatid development 4/255 165/18722 0.188316225514486 0.563498537494766 JAM3/CATSPER2/TTLL1/PLD6 4 GO:0048259 regulation of receptor-mediated endocytosis 3/255 110/18722 0.189455934939209 0.563498537494766 CLU/SERPINE1/ITGAV 3 GO:0061387 regulation of extent of cell growth 3/255 110/18722 0.189455934939209 0.563498537494766 SEMA4G/DISC1/BMPR2 3 GO:1905954 positive regulation of lipid localization 3/255 110/18722 0.189455934939209 0.563498537494766 NR1H3/ACSL1/ABCA1 3 GO:0030336 negative regulation of cell migration 7/255 344/18722 0.190497782001432 0.563498537494766 GJA1/CLDN19/SRGAP3/KANK1/SERPINE1/ADAM15/PTPRM 7 GO:0010959 regulation of metal ion transport 8/255 406/18722 0.190913070799904 0.563498537494766 EHD3/GJA1/TMC1/PSEN2/KCNG1/P2RX7/PRSS8/PDPK1 8 GO:0001836 release of cytochrome c from mitochondria 2/255 59/18722 0.191888971050078 0.563498537494766 CLU/DNM1L 2 GO:0021885 forebrain cell migration 2/255 59/18722 0.191888971050078 0.563498537494766 GLI3/DISC1 2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/255 59/18722 0.191888971050078 0.563498537494766 IRS1/PTK2 2 GO:0048278 vesicle docking 2/255 59/18722 0.191888971050078 0.563498537494766 SYT1/RAB15 2 GO:2000351 regulation of endothelial cell apoptotic process 2/255 59/18722 0.191888971050078 0.563498537494766 SERPINE1/PDPK1 2 GO:0010001 glial cell differentiation 5/255 225/18722 0.193603168549949 0.563498537494766 GPR157/S100A8/GLI3/CLU/ITGB4 5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 4/255 167/18722 0.193825135596861 0.563498537494766 DSC3/CLSTN3/TENM3/PTPRM 4 GO:0048562 embryonic organ morphogenesis 6/255 285/18722 0.194186477299066 0.563498537494766 FBN1/GLI3/SIX4/NAGLU/TWIST1/FBN2 6 GO:0016482 cytosolic transport 4/255 168/18722 0.196598424590746 0.563498537494766 EHD3/EVI5/RAB9B/CLN5 4 GO:0031102 neuron projection regeneration 2/255 60/18722 0.196835122771331 0.563498537494766 ISL1/JAM3 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/255 60/18722 0.196835122771331 0.563498537494766 SLC26A2/ACSL1 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/255 60/18722 0.196835122771331 0.563498537494766 SLC26A2/ACSL1 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/255 60/18722 0.196835122771331 0.563498537494766 SLC26A2/ACSL1 2 GO:0042306 regulation of protein import into nucleus 2/255 60/18722 0.196835122771331 0.563498537494766 GLI3/RAB23 2 GO:0055008 cardiac muscle tissue morphogenesis 2/255 60/18722 0.196835122771331 0.563498537494766 ISL1/LRP2 2 GO:1903670 regulation of sprouting angiogenesis 2/255 60/18722 0.196835122771331 0.563498537494766 EPN2/PDPK1 2 GO:0001977 renal system process involved in regulation of blood volume 1/255 16/18722 0.197089248474169 0.563498537494766 GJA1 1 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 1/255 16/18722 0.197089248474169 0.563498537494766 ENPEP 1 GO:0002371 dendritic cell cytokine production 1/255 16/18722 0.197089248474169 0.563498537494766 TLR3 1 GO:0002693 positive regulation of cellular extravasation 1/255 16/18722 0.197089248474169 0.563498537494766 JAM3 1 GO:0006206 pyrimidine nucleobase metabolic process 1/255 16/18722 0.197089248474169 0.563498537494766 CTPS2 1 GO:0006349 regulation of gene expression by genetic imprinting 1/255 16/18722 0.197089248474169 0.563498537494766 PRMT7 1 GO:0006740 NADPH regeneration 1/255 16/18722 0.197089248474169 0.563498537494766 SHPK 1 GO:0010649 regulation of cell communication by electrical coupling 1/255 16/18722 0.197089248474169 0.563498537494766 GJA1 1 GO:0017014 protein nitrosylation 1/255 16/18722 0.197089248474169 0.563498537494766 S100A8 1 GO:0018119 peptidyl-cysteine S-nitrosylation 1/255 16/18722 0.197089248474169 0.563498537494766 S100A8 1 GO:0021783 preganglionic parasympathetic fiber development 1/255 16/18722 0.197089248474169 0.563498537494766 NRP2 1 GO:0030033 microvillus assembly 1/255 16/18722 0.197089248474169 0.563498537494766 ATP8B1 1 GO:0030540 female genitalia development 1/255 16/18722 0.197089248474169 0.563498537494766 LRP2 1 GO:0032274 gonadotropin secretion 1/255 16/18722 0.197089248474169 0.563498537494766 GJA1 1 GO:0034138 toll-like receptor 3 signaling pathway 1/255 16/18722 0.197089248474169 0.563498537494766 TLR3 1 GO:0035067 negative regulation of histone acetylation 1/255 16/18722 0.197089248474169 0.563498537494766 TWIST1 1 GO:0035751 regulation of lysosomal lumen pH 1/255 16/18722 0.197089248474169 0.563498537494766 CLN5 1 GO:0042407 cristae formation 1/255 16/18722 0.197089248474169 0.563498537494766 CHCHD6 1 GO:0043923 positive regulation by host of viral transcription 1/255 16/18722 0.197089248474169 0.563498537494766 SP1 1 GO:0044804 autophagy of nucleus 1/255 16/18722 0.197089248474169 0.563498537494766 ATG7 1 GO:0045779 negative regulation of bone resorption 1/255 16/18722 0.197089248474169 0.563498537494766 P2RX7 1 GO:0045838 positive regulation of membrane potential 1/255 16/18722 0.197089248474169 0.563498537494766 PIAS3 1 GO:0046036 CTP metabolic process 1/255 16/18722 0.197089248474169 0.563498537494766 CTPS2 1 GO:0048557 embryonic digestive tract morphogenesis 1/255 16/18722 0.197089248474169 0.563498537494766 GLI3 1 GO:0051238 sequestering of metal ion 1/255 16/18722 0.197089248474169 0.563498537494766 S100A8 1 GO:0060004 reflex 1/255 16/18722 0.197089248474169 0.563498537494766 TMC1 1 GO:0060330 regulation of response to interferon-gamma 1/255 16/18722 0.197089248474169 0.563498537494766 NR1H3 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/255 16/18722 0.197089248474169 0.563498537494766 NR1H3 1 GO:0070242 thymocyte apoptotic process 1/255 16/18722 0.197089248474169 0.563498537494766 GLI3 1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 1/255 16/18722 0.197089248474169 0.563498537494766 TRMT61B 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/255 16/18722 0.197089248474169 0.563498537494766 TWIST1 1 GO:0080009 mRNA methylation 1/255 16/18722 0.197089248474169 0.563498537494766 TRMT61B 1 GO:1901163 regulation of trophoblast cell migration 1/255 16/18722 0.197089248474169 0.563498537494766 GJA1 1 GO:1905906 regulation of amyloid fibril formation 1/255 16/18722 0.197089248474169 0.563498537494766 CLU 1 GO:0043087 regulation of GTPase activity 7/255 348/18722 0.19799957020265 0.56558378142896 EFNA5/MET/EVI5/PLXND1/ARHGAP24/CHN2/PTK2 7 GO:0030865 cortical cytoskeleton organization 2/255 61/18722 0.20179691626649 0.566296057267595 STRIP1/FMNL2 2 GO:0043030 regulation of macrophage activation 2/255 61/18722 0.20179691626649 0.566296057267595 NR1H3/SHPK 2 GO:1905515 non-motile cilium assembly 2/255 61/18722 0.20179691626649 0.566296057267595 DISC1/INTU 2 GO:0030178 negative regulation of Wnt signaling pathway 4/255 170/18722 0.202181425508407 0.566296057267595 RNF43/GLI3/ISL1/CTNND1 4 GO:0019751 polyol metabolic process 3/255 114/18722 0.203345798771073 0.566296057267595 ASAH2B/SPR/PLPP3 3 GO:0021987 cerebral cortex development 3/255 114/18722 0.203345798771073 0.566296057267595 TACC2/GLI3/DISC1 3 GO:0046660 female sex differentiation 3/255 114/18722 0.203345798771073 0.566296057267595 LRP2/FANCA/IDH1 3 GO:0046890 regulation of lipid biosynthetic process 4/255 171/18722 0.204990639040132 0.566296057267595 NR1H3/STARD4/IDH1/SIRT3 4 GO:0051048 negative regulation of secretion 4/255 171/18722 0.204990639040132 0.566296057267595 GJA1/NR1H3/PPP1R9A/IRS1 4 GO:0045055 regulated exocytosis 5/255 230/18722 0.205493728494159 0.566296057267595 SYT1/RAB15/SYT8/PDPK1/DNM1L 5 GO:0009311 oligosaccharide metabolic process 2/255 62/18722 0.206773014701901 0.566296057267595 ST3GAL6/MANBA 2 GO:0032615 interleukin-12 production 2/255 62/18722 0.206773014701901 0.566296057267595 TLR3/ISL1 2 GO:0032655 regulation of interleukin-12 production 2/255 62/18722 0.206773014701901 0.566296057267595 TLR3/ISL1 2 GO:0032731 positive regulation of interleukin-1 beta production 2/255 62/18722 0.206773014701901 0.566296057267595 ISL1/P2RX7 2 GO:0032757 positive regulation of interleukin-8 production 2/255 62/18722 0.206773014701901 0.566296057267595 TLR3/SERPINE1 2 GO:0046173 polyol biosynthetic process 2/255 62/18722 0.206773014701901 0.566296057267595 ASAH2B/SPR 2 GO:0046847 filopodium assembly 2/255 62/18722 0.206773014701901 0.566296057267595 PPP1R9A/ITGB4 2 GO:0048663 neuron fate commitment 2/255 62/18722 0.206773014701901 0.566296057267595 GLI3/ISL1 2 GO:0070265 necrotic cell death 2/255 62/18722 0.206773014701901 0.566296057267595 TLR3/DNM1L 2 GO:1903078 positive regulation of protein localization to plasma membrane 2/255 62/18722 0.206773014701901 0.566296057267595 ITGA3/PDPK1 2 GO:0034968 histone lysine methylation 3/255 115/18722 0.206855092101206 0.566296057267595 N6AMT1/SETD6/ZNF335 3 GO:0042471 ear morphogenesis 3/255 115/18722 0.206855092101206 0.566296057267595 SIX4/NAGLU/TWIST1 3 GO:0002221 pattern recognition receptor signaling pathway 4/255 172/18722 0.207811328948014 0.566296057267595 TLR3/NR1H3/ZCCHC3/PDPK1 4 GO:0048515 spermatid differentiation 4/255 172/18722 0.207811328948014 0.566296057267595 JAM3/CATSPER2/TTLL1/PLD6 4 GO:1901136 carbohydrate derivative catabolic process 4/255 172/18722 0.207811328948014 0.566296057267595 PDE10A/NAGLU/MANBA/GNS 4 GO:0007096 regulation of exit from mitosis 1/255 17/18722 0.208034519597824 0.566296057267595 KNTC1 1 GO:0007158 neuron cell-cell adhesion 1/255 17/18722 0.208034519597824 0.566296057267595 NRXN3 1 GO:0007351 tripartite regional subdivision 1/255 17/18722 0.208034519597824 0.566296057267595 PLD6 1 GO:0007379 segment specification 1/255 17/18722 0.208034519597824 0.566296057267595 COBL 1 GO:0008595 anterior/posterior axis specification, embryo 1/255 17/18722 0.208034519597824 0.566296057267595 PLD6 1 GO:0010715 regulation of extracellular matrix disassembly 1/255 17/18722 0.208034519597824 0.566296057267595 DDR1 1 GO:0015867 ATP transport 1/255 17/18722 0.208034519597824 0.566296057267595 GJA1 1 GO:0016264 gap junction assembly 1/255 17/18722 0.208034519597824 0.566296057267595 GJA1 1 GO:0021692 cerebellar Purkinje cell layer morphogenesis 1/255 17/18722 0.208034519597824 0.566296057267595 TTLL1 1 GO:0030903 notochord development 1/255 17/18722 0.208034519597824 0.566296057267595 COBL 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/255 17/18722 0.208034519597824 0.566296057267595 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/255 17/18722 0.208034519597824 0.566296057267595 ISL1 1 GO:0033623 regulation of integrin activation 1/255 17/18722 0.208034519597824 0.566296057267595 JAM3 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/255 17/18722 0.208034519597824 0.566296057267595 BCAR1 1 GO:0036035 osteoclast development 1/255 17/18722 0.208034519597824 0.566296057267595 FBN1 1 GO:0043117 positive regulation of vascular permeability 1/255 17/18722 0.208034519597824 0.566296057267595 CXCR2 1 GO:0044539 long-chain fatty acid import into cell 1/255 17/18722 0.208034519597824 0.566296057267595 ACSL1 1 GO:0046068 cGMP metabolic process 1/255 17/18722 0.208034519597824 0.566296057267595 PDE10A 1 GO:0048532 anatomical structure arrangement 1/255 17/18722 0.208034519597824 0.566296057267595 NRP2 1 GO:0060977 coronary vasculature morphogenesis 1/255 17/18722 0.208034519597824 0.566296057267595 LRP2 1 GO:0061298 retina vasculature development in camera-type eye 1/255 17/18722 0.208034519597824 0.566296057267595 BMPR2 1 GO:0070875 positive regulation of glycogen metabolic process 1/255 17/18722 0.208034519597824 0.566296057267595 IRS1 1 GO:0072673 lamellipodium morphogenesis 1/255 17/18722 0.208034519597824 0.566296057267595 KANK1 1 GO:0090083 regulation of inclusion body assembly 1/255 17/18722 0.208034519597824 0.566296057267595 CLU 1 GO:0090399 replicative senescence 1/255 17/18722 0.208034519597824 0.566296057267595 SERPINE1 1 GO:0140354 lipid import into cell 1/255 17/18722 0.208034519597824 0.566296057267595 ACSL1 1 GO:1903358 regulation of Golgi organization 1/255 17/18722 0.208034519597824 0.566296057267595 EHD3 1 GO:1903830 magnesium ion transmembrane transport 1/255 17/18722 0.208034519597824 0.566296057267595 ZDHHC13 1 GO:2000811 negative regulation of anoikis 1/255 17/18722 0.208034519597824 0.566296057267595 PTK2 1 GO:0008286 insulin receptor signaling pathway 3/255 116/18722 0.21037812824736 0.567508200397392 BCAR1/IRS1/KANK1 3 GO:0021782 glial cell development 3/255 116/18722 0.21037812824736 0.567508200397392 S100A8/CLU/ITGB4 3 GO:0022617 extracellular matrix disassembly 2/255 63/18722 0.211762114487396 0.567508200397392 DDR1/ADAM15 2 GO:0030239 myofibril assembly 2/255 63/18722 0.211762114487396 0.567508200397392 TNNT3/SIX4 2 GO:1904589 regulation of protein import 2/255 63/18722 0.211762114487396 0.567508200397392 GLI3/RAB23 2 GO:2000756 regulation of peptidyl-lysine acetylation 2/255 63/18722 0.211762114487396 0.567508200397392 ISL1/TWIST1 2 GO:0051604 protein maturation 6/255 294/18722 0.213218195684209 0.567508200397392 ENPEP/GLI3/PISD/PSEN2/CLN5/SERPINE1 6 GO:0001659 temperature homeostasis 4/255 174/18722 0.213486141104104 0.567508200397392 GJA1/NR1H3/ACSL1/PRKAB1 4 GO:1904062 regulation of cation transmembrane transport 7/255 357/18722 0.215292125568243 0.567508200397392 EHD3/TMC1/CNIH3/PSEN2/TWIST1/KCNG1/PDPK1 7 GO:0046879 hormone secretion 6/255 295/18722 0.215372321835558 0.567508200397392 EFNA5/GJA1/ISL1/KDM5B/IRS1/SIRT3 6 GO:0048771 tissue remodeling 4/255 175/18722 0.216339765260384 0.567508200397392 GJA1/P2RX7/BMPR2/CA2 4 GO:0017156 calcium-ion regulated exocytosis 2/255 64/18722 0.216762944624773 0.567508200397392 SYT1/SYT8 2 GO:0030104 water homeostasis 2/255 64/18722 0.216762944624773 0.567508200397392 MYO5B/MET 2 GO:0030837 negative regulation of actin filament polymerization 2/255 64/18722 0.216762944624773 0.567508200397392 KANK4/KANK1 2 GO:0032507 maintenance of protein location in cell 2/255 64/18722 0.216762944624773 0.567508200397392 GJA1/KDELR3 2 GO:0046888 negative regulation of hormone secretion 2/255 64/18722 0.216762944624773 0.567508200397392 GJA1/IRS1 2 GO:0055002 striated muscle cell development 2/255 64/18722 0.216762944624773 0.567508200397392 TNNT3/SIX4 2 GO:0070542 response to fatty acid 2/255 64/18722 0.216762944624773 0.567508200397392 IRS1/ACSL1 2 GO:1900076 regulation of cellular response to insulin stimulus 2/255 64/18722 0.216762944624773 0.567508200397392 IRS1/KANK1 2 GO:0048193 Golgi vesicle transport 6/255 296/18722 0.217533977993758 0.567508200397392 EHD3/KDELR3/PLPP3/COG6/LMAN2L/RP2 6 GO:0001946 lymphangiogenesis 1/255 18/18722 0.218831162073234 0.567508200397392 BMPR2 1 GO:0002223 stimulatory C-type lectin receptor signaling pathway 1/255 18/18722 0.218831162073234 0.567508200397392 PAK3 1 GO:0006103 2-oxoglutarate metabolic process 1/255 18/18722 0.218831162073234 0.567508200397392 IDH1 1 GO:0007250 activation of NF-kappaB-inducing kinase activity 1/255 18/18722 0.218831162073234 0.567508200397392 TLR3 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/255 18/18722 0.218831162073234 0.567508200397392 CTPS2 1 GO:0009404 toxin metabolic process 1/255 18/18722 0.218831162073234 0.567508200397392 N6AMT1 1 GO:0010663 positive regulation of striated muscle cell apoptotic process 1/255 18/18722 0.218831162073234 0.567508200397392 CXCR2 1 GO:0010666 positive regulation of cardiac muscle cell apoptotic process 1/255 18/18722 0.218831162073234 0.567508200397392 CXCR2 1 GO:0015693 magnesium ion transport 1/255 18/18722 0.218831162073234 0.567508200397392 ZDHHC13 1 GO:0030206 chondroitin sulfate biosynthetic process 1/255 18/18722 0.218831162073234 0.567508200397392 CHST3 1 GO:0034433 steroid esterification 1/255 18/18722 0.218831162073234 0.567508200397392 STARD4 1 GO:0034434 sterol esterification 1/255 18/18722 0.218831162073234 0.567508200397392 STARD4 1 GO:0034435 cholesterol esterification 1/255 18/18722 0.218831162073234 0.567508200397392 STARD4 1 GO:0034587 piRNA metabolic process 1/255 18/18722 0.218831162073234 0.567508200397392 PLD6 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/255 18/18722 0.218831162073234 0.567508200397392 DDX11 1 GO:0043217 myelin maintenance 1/255 18/18722 0.218831162073234 0.567508200397392 CLU 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/255 18/18722 0.218831162073234 0.567508200397392 SYT1 1 GO:0046112 nucleobase biosynthetic process 1/255 18/18722 0.218831162073234 0.567508200397392 CTPS2 1 GO:0046851 negative regulation of bone remodeling 1/255 18/18722 0.218831162073234 0.567508200397392 P2RX7 1 GO:0048486 parasympathetic nervous system development 1/255 18/18722 0.218831162073234 0.567508200397392 NRP2 1 GO:0051382 kinetochore assembly 1/255 18/18722 0.218831162073234 0.567508200397392 KNTC1 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/255 18/18722 0.218831162073234 0.567508200397392 BMPR2 1 GO:0060457 negative regulation of digestive system process 1/255 18/18722 0.218831162073234 0.567508200397392 NR1H3 1 GO:0060602 branch elongation of an epithelium 1/255 18/18722 0.218831162073234 0.567508200397392 SIX4 1 GO:0060749 mammary gland alveolus development 1/255 18/18722 0.218831162073234 0.567508200397392 DDR1 1 GO:0060973 cell migration involved in heart development 1/255 18/18722 0.218831162073234 0.567508200397392 TWIST1 1 GO:0061377 mammary gland lobule development 1/255 18/18722 0.218831162073234 0.567508200397392 DDR1 1 GO:0071071 regulation of phospholipid biosynthetic process 1/255 18/18722 0.218831162073234 0.567508200397392 IDH1 1 GO:0071318 cellular response to ATP 1/255 18/18722 0.218831162073234 0.567508200397392 P2RX7 1 GO:0072079 nephron tubule formation 1/255 18/18722 0.218831162073234 0.567508200397392 SIX4 1 GO:0080182 histone H3-K4 trimethylation 1/255 18/18722 0.218831162073234 0.567508200397392 ZNF335 1 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 1/255 18/18722 0.218831162073234 0.567508200397392 SIX4 1 GO:1900006 positive regulation of dendrite development 1/255 18/18722 0.218831162073234 0.567508200397392 COBL 1 GO:1900242 regulation of synaptic vesicle endocytosis 1/255 18/18722 0.218831162073234 0.567508200397392 DNM1L 1 GO:1902001 fatty acid transmembrane transport 1/255 18/18722 0.218831162073234 0.567508200397392 ACSL1 1 GO:1990840 response to lectin 1/255 18/18722 0.218831162073234 0.567508200397392 PAK3 1 GO:1990858 cellular response to lectin 1/255 18/18722 0.218831162073234 0.567508200397392 PAK3 1 GO:2000146 negative regulation of cell motility 7/255 359/18722 0.219208767382295 0.568016084634886 GJA1/CLDN19/SRGAP3/KANK1/SERPINE1/ADAM15/PTPRM 7 GO:0030072 peptide hormone secretion 5/255 236/18722 0.2200724950761 0.569149767679923 EFNA5/GJA1/ISL1/IRS1/SIRT3 5 GO:0003170 heart valve development 2/255 65/18722 0.221774266067737 0.569149767679923 TWIST1/BMPR2 2 GO:0033692 cellular polysaccharide biosynthetic process 2/255 65/18722 0.221774266067737 0.569149767679923 B3GNT3/IRS1 2 GO:0045453 bone resorption 2/255 65/18722 0.221774266067737 0.569149767679923 P2RX7/CA2 2 GO:1905330 regulation of morphogenesis of an epithelium 2/255 65/18722 0.221774266067737 0.569149767679923 GJA1/SIX4 2 GO:0031647 regulation of protein stability 6/255 298/18722 0.22187947342367 0.569149767679923 PLPP3/PARVA/USP27X/CLU/CTNND1/USP19 6 GO:0030324 lung development 4/255 177/18722 0.222078206007728 0.569149767679923 LAMA5/GLI3/ITGA3/BMPR2 4 GO:0051302 regulation of cell division 4/255 177/18722 0.222078206007728 0.569149767679923 GAREM1/BTC/SUSD2/INTU 4 GO:0071453 cellular response to oxygen levels 4/255 177/18722 0.222078206007728 0.569149767679923 TWIST1/ATG7/USP19/DNM1L 4 GO:0071466 cellular response to xenobiotic stimulus 4/255 177/18722 0.222078206007728 0.569149767679923 TLR3/N6AMT1/ACSL1/ABCA1 4 GO:0070997 neuron death 7/255 361/18722 0.223151004789294 0.569149767679923 SNCG/PAK3/ISL1/SIX4/CLU/ATG7/PDPK1 7 GO:0006304 DNA modification 3/255 120/18722 0.22459798589998 0.569149767679923 N6AMT1/PRMT7/PLD6 3 GO:0051897 positive regulation of protein kinase B signaling 3/255 120/18722 0.22459798589998 0.569149767679923 MET/LRP2/PTK2 3 GO:0019229 regulation of vasoconstriction 2/255 66/18722 0.22679487109313 0.569149767679923 GJA1/BMPR2 2 GO:0046626 regulation of insulin receptor signaling pathway 2/255 66/18722 0.22679487109313 0.569149767679923 IRS1/KANK1 2 GO:0051893 regulation of focal adhesion assembly 2/255 66/18722 0.22679487109313 0.569149767679923 EFNA5/PTK2 2 GO:0090109 regulation of cell-substrate junction assembly 2/255 66/18722 0.22679487109313 0.569149767679923 EFNA5/PTK2 2 GO:1902476 chloride transmembrane transport 2/255 66/18722 0.22679487109313 0.569149767679923 GABRE/SLC26A2 2 GO:0034765 regulation of ion transmembrane transport 9/255 491/18722 0.227853889441868 0.569149767679923 EHD3/TMC1/CATSPER2/CNIH3/PSEN2/TWIST1/KCNG1/P2RX7/PDPK1 9 GO:0006399 tRNA metabolic process 4/255 179/18722 0.227856581756053 0.569149767679923 YARS2/TYW1/TRMT61B/TSEN15 4 GO:0007416 synapse assembly 4/255 179/18722 0.227856581756053 0.569149767679923 PPP1R9A/SIX4/CLSTN3/PLXND1 4 GO:0002224 toll-like receptor signaling pathway 3/255 121/18722 0.228182480770232 0.569149767679923 TLR3/NR1H3/PDPK1 3 GO:1904019 epithelial cell apoptotic process 3/255 121/18722 0.228182480770232 0.569149767679923 SERPINE1/BMPR2/PDPK1 3 GO:0003085 negative regulation of systemic arterial blood pressure 1/255 19/18722 0.229481186328545 0.569149767679923 BMPR2 1 GO:0006044 N-acetylglucosamine metabolic process 1/255 19/18722 0.229481186328545 0.569149767679923 CHST3 1 GO:0007039 protein catabolic process in the vacuole 1/255 19/18722 0.229481186328545 0.569149767679923 LRP2 1 GO:0007530 sex determination 1/255 19/18722 0.229481186328545 0.569149767679923 SIX4 1 GO:0008356 asymmetric cell division 1/255 19/18722 0.229481186328545 0.569149767679923 TEAD3 1 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 1/255 19/18722 0.229481186328545 0.569149767679923 CTPS2 1 GO:0010002 cardioblast differentiation 1/255 19/18722 0.229481186328545 0.569149767679923 ISL1 1 GO:0010759 positive regulation of macrophage chemotaxis 1/255 19/18722 0.229481186328545 0.569149767679923 PTK2 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/255 19/18722 0.229481186328545 0.569149767679923 TWIST1 1 GO:0030011 maintenance of cell polarity 1/255 19/18722 0.229481186328545 0.569149767679923 DST 1 GO:0030050 vesicle transport along actin filament 1/255 19/18722 0.229481186328545 0.569149767679923 MYO5B 1 GO:0033194 response to hydroperoxide 1/255 19/18722 0.229481186328545 0.569149767679923 SP1 1 GO:0034501 protein localization to kinetochore 1/255 19/18722 0.229481186328545 0.569149767679923 KNTC1 1 GO:0035313 wound healing, spreading of epidermal cells 1/255 19/18722 0.229481186328545 0.569149767679923 ARHGAP24 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/255 19/18722 0.229481186328545 0.569149767679923 ACSL1 1 GO:0035728 response to hepatocyte growth factor 1/255 19/18722 0.229481186328545 0.569149767679923 BCAR1 1 GO:0042474 middle ear morphogenesis 1/255 19/18722 0.229481186328545 0.569149767679923 NAGLU 1 GO:0043031 negative regulation of macrophage activation 1/255 19/18722 0.229481186328545 0.569149767679923 NR1H3 1 GO:0044003 modulation by symbiont of host process 1/255 19/18722 0.229481186328545 0.569149767679923 ATG7 1 GO:0045780 positive regulation of bone resorption 1/255 19/18722 0.229481186328545 0.569149767679923 CA2 1 GO:0045821 positive regulation of glycolytic process 1/255 19/18722 0.229481186328545 0.569149767679923 P2RX7 1 GO:0060065 uterus development 1/255 19/18722 0.229481186328545 0.569149767679923 KDM5B 1 GO:0072074 kidney mesenchyme development 1/255 19/18722 0.229481186328545 0.569149767679923 SIX4 1 GO:0086014 atrial cardiac muscle cell action potential 1/255 19/18722 0.229481186328545 0.569149767679923 GJA1 1 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 1/255 19/18722 0.229481186328545 0.569149767679923 GJA1 1 GO:0086066 atrial cardiac muscle cell to AV node cell communication 1/255 19/18722 0.229481186328545 0.569149767679923 GJA1 1 GO:1900221 regulation of amyloid-beta clearance 1/255 19/18722 0.229481186328545 0.569149767679923 CLU 1 GO:1901659 glycosyl compound biosynthetic process 1/255 19/18722 0.229481186328545 0.569149767679923 TYW1 1 GO:1901881 positive regulation of protein depolymerization 1/255 19/18722 0.229481186328545 0.569149767679923 KATNB1 1 GO:1903083 protein localization to condensed chromosome 1/255 19/18722 0.229481186328545 0.569149767679923 KNTC1 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/255 19/18722 0.229481186328545 0.569149767679923 ATG7 1 GO:0032886 regulation of microtubule-based process 5/255 240/18722 0.229964561640336 0.569896316515504 EFNA5/MET/KLHL42/KATNB1/SPICE1 5 GO:0010721 negative regulation of cell development 4/255 180/18722 0.230760126074353 0.571414733741959 EFNA5/SEMA4G/FBN1/KANK1 4 GO:0051928 positive regulation of calcium ion transport 3/255 122/18722 0.231777841578648 0.572686716114727 EHD3/P2RX7/PDPK1 3 GO:0072329 monocarboxylic acid catabolic process 3/255 122/18722 0.231777841578648 0.572686716114727 ACADS/IRS1/TWIST1 3 GO:0061180 mammary gland epithelium development 2/255 67/18722 0.231823582683242 0.572686716114727 DDR1/KDM5B 2 GO:0051222 positive regulation of protein transport 6/255 303/18722 0.232867829875261 0.573083957536253 GJA1/GLI3/ISL1/SIRT3/ADAM9/DNM1L 6 GO:0060070 canonical Wnt signaling pathway 6/255 303/18722 0.232867829875261 0.573083957536253 GLI3/ISL1/PLPP3/DISC1/KANK1/CTNND1 6 GO:0006479 protein methylation 4/255 181/18722 0.233672912023943 0.573083957536253 N6AMT1/PRMT7/SETD6/ZNF335 4 GO:0008213 protein alkylation 4/255 181/18722 0.233672912023943 0.573083957536253 N6AMT1/PRMT7/SETD6/ZNF335 4 GO:0008361 regulation of cell size 4/255 181/18722 0.233672912023943 0.573083957536253 SEMA4G/DISC1/P2RX7/BMPR2 4 GO:0030323 respiratory tube development 4/255 181/18722 0.233672912023943 0.573083957536253 LAMA5/GLI3/ITGA3/BMPR2 4 GO:0032640 tumor necrosis factor production 4/255 181/18722 0.233672912023943 0.573083957536253 TLR3/ISL1/CLU/TWIST1 4 GO:0032680 regulation of tumor necrosis factor production 4/255 181/18722 0.233672912023943 0.573083957536253 TLR3/ISL1/CLU/TWIST1 4 GO:0099504 synaptic vesicle cycle 4/255 181/18722 0.233672912023943 0.573083957536253 SYT1/SNCG/SYT8/DNM1L 4 GO:0051271 negative regulation of cellular component movement 7/255 367/18722 0.235125348256477 0.573083957536253 GJA1/CLDN19/SRGAP3/KANK1/SERPINE1/ADAM15/PTPRM 7 GO:0003231 cardiac ventricle development 3/255 123/18722 0.235383601871553 0.573083957536253 ISL1/LRP2/BMPR2 3 GO:0010811 positive regulation of cell-substrate adhesion 3/255 123/18722 0.235383601871553 0.573083957536253 CCDC80/ITGA3/DISC1 3 GO:0051260 protein homooligomerization 4/255 182/18722 0.236594693256503 0.573083957536253 EHD3/MPP2/KCNG1/TRMT61B 4 GO:0051148 negative regulation of muscle cell differentiation 2/255 68/18722 0.236859253919032 0.573083957536253 BHLHE41/BMPR2 2 GO:0097237 cellular response to toxic substance 3/255 124/18722 0.238999299126916 0.573083957536253 ABTB2/PPP1R9A/TXNRD2 3 GO:0009914 hormone transport 6/255 306/18722 0.239542162009957 0.573083957536253 EFNA5/GJA1/ISL1/KDM5B/IRS1/SIRT3 6 GO:0000963 mitochondrial RNA processing 1/255 20/18722 0.239986575703844 0.573083957536253 TRMT61B 1 GO:0003215 cardiac right ventricle morphogenesis 1/255 20/18722 0.239986575703844 0.573083957536253 ISL1 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/255 20/18722 0.239986575703844 0.573083957536253 PSEN2 1 GO:0006896 Golgi to vacuole transport 1/255 20/18722 0.239986575703844 0.573083957536253 EHD3 1 GO:0007097 nuclear migration 1/255 20/18722 0.239986575703844 0.573083957536253 TMEM201 1 GO:0010042 response to manganese ion 1/255 20/18722 0.239986575703844 0.573083957536253 ADAM9 1 GO:0010893 positive regulation of steroid biosynthetic process 1/255 20/18722 0.239986575703844 0.573083957536253 STARD4 1 GO:0014047 glutamate secretion 1/255 20/18722 0.239986575703844 0.573083957536253 GJA1 1 GO:0015669 gas transport 1/255 20/18722 0.239986575703844 0.573083957536253 CA2 1 GO:0017121 plasma membrane phospholipid scrambling 1/255 20/18722 0.239986575703844 0.573083957536253 P2RX7 1 GO:0032332 positive regulation of chondrocyte differentiation 1/255 20/18722 0.239986575703844 0.573083957536253 GLI3 1 GO:0032495 response to muramyl dipeptide 1/255 20/18722 0.239986575703844 0.573083957536253 LDOC1 1 GO:0034104 negative regulation of tissue remodeling 1/255 20/18722 0.239986575703844 0.573083957536253 P2RX7 1 GO:0039535 regulation of RIG-I signaling pathway 1/255 20/18722 0.239986575703844 0.573083957536253 ZCCHC3 1 GO:0042359 vitamin D metabolic process 1/255 20/18722 0.239986575703844 0.573083957536253 LRP2 1 GO:0043011 myeloid dendritic cell differentiation 1/255 20/18722 0.239986575703844 0.573083957536253 ITGB8 1 GO:0046931 pore complex assembly 1/255 20/18722 0.239986575703844 0.573083957536253 P2RX7 1 GO:0051004 regulation of lipoprotein lipase activity 1/255 20/18722 0.239986575703844 0.573083957536253 NR1H3 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/255 20/18722 0.239986575703844 0.573083957536253 GJA1 1 GO:0070166 enamel mineralization 1/255 20/18722 0.239986575703844 0.573083957536253 SLC4A2 1 GO:0071397 cellular response to cholesterol 1/255 20/18722 0.239986575703844 0.573083957536253 ABCA1 1 GO:0090201 negative regulation of release of cytochrome c from mitochondria 1/255 20/18722 0.239986575703844 0.573083957536253 CLU 1 GO:0097503 sialylation 1/255 20/18722 0.239986575703844 0.573083957536253 ST3GAL6 1 GO:1901679 nucleotide transmembrane transport 1/255 20/18722 0.239986575703844 0.573083957536253 SLC19A1 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/255 20/18722 0.239986575703844 0.573083957536253 MET 1 GO:1904292 regulation of ERAD pathway 1/255 20/18722 0.239986575703844 0.573083957536253 USP19 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/255 20/18722 0.239986575703844 0.573083957536253 TWIST1 1 GO:0019226 transmission of nerve impulse 2/255 69/18722 0.241900767384085 0.573083957536253 CLDN19/JAM3 2 GO:0033344 cholesterol efflux 2/255 69/18722 0.241900767384085 0.573083957536253 NR1H3/ABCA1 2 GO:0051966 regulation of synaptic transmission, glutamatergic 2/255 69/18722 0.241900767384085 0.573083957536253 SYT1/DISC1 2 GO:0060193 positive regulation of lipase activity 2/255 69/18722 0.241900767384085 0.573083957536253 NR1H3/PDPK1 2 GO:1904377 positive regulation of protein localization to cell periphery 2/255 69/18722 0.241900767384085 0.573083957536253 ITGA3/PDPK1 2 GO:0051053 negative regulation of DNA metabolic process 3/255 125/18722 0.242624474824027 0.573083957536253 GJA1/TWIST1/BMPR2 3 GO:0070585 protein localization to mitochondrion 3/255 125/18722 0.242624474824027 0.573083957536253 TIMM8A/TOMM34/DNM1L 3 GO:0045862 positive regulation of proteolysis 7/255 372/18722 0.245264147366407 0.573083957536253 S100A8/SH3D19/DISC1/CLU/HSPBP1/PTK2/ADAM9 7 GO:0045785 positive regulation of cell adhesion 8/255 437/18722 0.246728693564497 0.573083957536253 CCDC80/EPB41L4B/GLI3/ITGA3/PLPP3/DISC1/ITGAV/ADAM9 8 GO:0003407 neural retina development 2/255 70/18722 0.246947034579103 0.573083957536253 NAGLU/PTPRM 2 GO:0060415 muscle tissue morphogenesis 2/255 70/18722 0.246947034579103 0.573083957536253 ISL1/LRP2 2 GO:0070830 bicellular tight junction assembly 2/255 70/18722 0.246947034579103 0.573083957536253 GJA1/CLDN19 2 GO:0031345 negative regulation of cell projection organization 4/255 186/18722 0.248366865323643 0.573083957536253 SEMA4G/ITGA3/KANK1/ARHGAP24 4 GO:0071706 tumor necrosis factor superfamily cytokine production 4/255 186/18722 0.248366865323643 0.573083957536253 TLR3/ISL1/CLU/TWIST1 4 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 4/255 186/18722 0.248366865323643 0.573083957536253 TLR3/ISL1/CLU/TWIST1 4 GO:0032409 regulation of transporter activity 6/255 310/18722 0.248530304622982 0.573083957536253 EHD3/GJA1/NR1H3/CNIH3/TWIST1/KCNG1 6 GO:0008033 tRNA processing 3/255 127/18722 0.249901447858785 0.573083957536253 TYW1/TRMT61B/TSEN15 3 GO:0030048 actin filament-based movement 3/255 127/18722 0.249901447858785 0.573083957536253 GJA1/MYO5B/PARVA 3 GO:0035270 endocrine system development 3/255 127/18722 0.249901447858785 0.573083957536253 ISL1/PBX1/PDPK1 3 GO:0048565 digestive tract development 3/255 127/18722 0.249901447858785 0.573083957536253 COBL/GLI3/SLC4A2 3 GO:0051224 negative regulation of protein transport 3/255 127/18722 0.249901447858785 0.573083957536253 NR1H3/IRS1/RAB23 3 GO:0003091 renal water homeostasis 1/255 21/18722 0.250349286814716 0.573083957536253 MYO5B 1 GO:0003177 pulmonary valve development 1/255 21/18722 0.250349286814716 0.573083957536253 BMPR2 1 GO:0006925 inflammatory cell apoptotic process 1/255 21/18722 0.250349286814716 0.573083957536253 CXCR2 1 GO:0007063 regulation of sister chromatid cohesion 1/255 21/18722 0.250349286814716 0.573083957536253 DDX11 1 GO:0007252 I-kappaB phosphorylation 1/255 21/18722 0.250349286814716 0.573083957536253 TLR3 1 GO:0008090 retrograde axonal transport 1/255 21/18722 0.250349286814716 0.573083957536253 DST 1 GO:0021533 cell differentiation in hindbrain 1/255 21/18722 0.250349286814716 0.573083957536253 TTLL1 1 GO:0022010 central nervous system myelination 1/255 21/18722 0.250349286814716 0.573083957536253 CLU 1 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 1/255 21/18722 0.250349286814716 0.573083957536253 SYT1 1 GO:0032288 myelin assembly 1/255 21/18722 0.250349286814716 0.573083957536253 ITGB4 1 GO:0032291 axon ensheathment in central nervous system 1/255 21/18722 0.250349286814716 0.573083957536253 CLU 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/255 21/18722 0.250349286814716 0.573083957536253 ADAM9 1 GO:0035020 regulation of Rac protein signal transduction 1/255 21/18722 0.250349286814716 0.573083957536253 ARHGAP24 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/255 21/18722 0.250349286814716 0.573083957536253 DDR1 1 GO:0045056 transcytosis 1/255 21/18722 0.250349286814716 0.573083957536253 LRP2 1 GO:0046514 ceramide catabolic process 1/255 21/18722 0.250349286814716 0.573083957536253 ASAH2B 1 GO:0046599 regulation of centriole replication 1/255 21/18722 0.250349286814716 0.573083957536253 SPICE1 1 GO:0046823 negative regulation of nucleocytoplasmic transport 1/255 21/18722 0.250349286814716 0.573083957536253 RAB23 1 GO:0048485 sympathetic nervous system development 1/255 21/18722 0.250349286814716 0.573083957536253 NRP2 1 GO:0050908 detection of light stimulus involved in visual perception 1/255 21/18722 0.250349286814716 0.573083957536253 EYS 1 GO:0050962 detection of light stimulus involved in sensory perception 1/255 21/18722 0.250349286814716 0.573083957536253 EYS 1 GO:0060117 auditory receptor cell development 1/255 21/18722 0.250349286814716 0.573083957536253 TMC1 1 GO:0070584 mitochondrion morphogenesis 1/255 21/18722 0.250349286814716 0.573083957536253 DNM1L 1 GO:0071498 cellular response to fluid shear stress 1/255 21/18722 0.250349286814716 0.573083957536253 CA2 1 GO:0071605 monocyte chemotactic protein-1 production 1/255 21/18722 0.250349286814716 0.573083957536253 TWIST1 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/255 21/18722 0.250349286814716 0.573083957536253 TWIST1 1 GO:0072170 metanephric tubule development 1/255 21/18722 0.250349286814716 0.573083957536253 CXCR2 1 GO:0090026 positive regulation of monocyte chemotaxis 1/255 21/18722 0.250349286814716 0.573083957536253 SERPINE1 1 GO:0090141 positive regulation of mitochondrial fission 1/255 21/18722 0.250349286814716 0.573083957536253 DNM1L 1 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 1/255 21/18722 0.250349286814716 0.573083957536253 SIX4 1 GO:0097062 dendritic spine maintenance 1/255 21/18722 0.250349286814716 0.573083957536253 ITGA3 1 GO:0099500 vesicle fusion to plasma membrane 1/255 21/18722 0.250349286814716 0.573083957536253 SYT1 1 GO:0099515 actin filament-based transport 1/255 21/18722 0.250349286814716 0.573083957536253 MYO5B 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/255 21/18722 0.250349286814716 0.573083957536253 KCNG1 1 GO:1902473 regulation of protein localization to synapse 1/255 21/18722 0.250349286814716 0.573083957536253 CLSTN3 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/255 21/18722 0.250349286814716 0.573083957536253 SIX4 1 GO:0050804 modulation of chemical synaptic transmission 8/255 439/18722 0.250506459518247 0.573083957536253 SYT1/LZTS1/SNCG/PPP1R9A/DISC1/CLSTN3/MPP2/DNM1L 8 GO:0018108 peptidyl-tyrosine phosphorylation 7/255 375/18722 0.251413045893298 0.573972748147749 EFNA5/BTC/MET/DDR1/ISL1/WEE1/PTK2 7 GO:0003208 cardiac ventricle morphogenesis 2/255 71/18722 0.251996995346788 0.573972748147749 ISL1/LRP2 2 GO:0003281 ventricular septum development 2/255 71/18722 0.251996995346788 0.573972748147749 LRP2/BMPR2 2 GO:0032722 positive regulation of chemokine production 2/255 71/18722 0.251996995346788 0.573972748147749 TLR3/TWIST1 2 GO:0043550 regulation of lipid kinase activity 2/255 71/18722 0.251996995346788 0.573972748147749 IRS1/PTK2 2 GO:0150116 regulation of cell-substrate junction organization 2/255 71/18722 0.251996995346788 0.573972748147749 EFNA5/PTK2 2 GO:0099177 regulation of trans-synaptic signaling 8/255 440/18722 0.252402393531922 0.574477406982706 SYT1/LZTS1/SNCG/PPP1R9A/DISC1/CLSTN3/MPP2/DNM1L 8 GO:0019932 second-messenger-mediated signaling 6/255 312/18722 0.253060643335479 0.575000790856474 CXCR2/PDE10A/PPP1R9A/LMCD1/P2RX7/PDPK1 6 GO:0018205 peptidyl-lysine modification 7/255 376/18722 0.253473151986392 0.575000790856474 ISL1/N6AMT1/TWIST1/SIRT3/PIAS3/SETD6/ZNF335 7 GO:0033865 nucleoside bisphosphate metabolic process 3/255 128/18722 0.253552348736071 0.575000790856474 SLC26A2/ACSL1/TPST2 3 GO:0033875 ribonucleoside bisphosphate metabolic process 3/255 128/18722 0.253552348736071 0.575000790856474 SLC26A2/ACSL1/TPST2 3 GO:0034032 purine nucleoside bisphosphate metabolic process 3/255 128/18722 0.253552348736071 0.575000790856474 SLC26A2/ACSL1/TPST2 3 GO:0030308 negative regulation of cell growth 4/255 188/18722 0.254300565025249 0.576279380495942 SEMA4G/GJA1/ADAM15/BMPR2 4 GO:0000271 polysaccharide biosynthetic process 2/255 72/18722 0.257049617306908 0.577097913516403 B3GNT3/IRS1 2 GO:0032729 positive regulation of interferon-gamma production 2/255 72/18722 0.257049617306908 0.577097913516403 TLR3/ISL1 2 GO:0042246 tissue regeneration 2/255 72/18722 0.257049617306908 0.577097913516403 EYS/ADAM15 2 GO:0050709 negative regulation of protein secretion 2/255 72/18722 0.257049617306908 0.577097913516403 NR1H3/IRS1 2 GO:0060249 anatomical structure homeostasis 6/255 314/18722 0.257614035903815 0.577097913516403 POTEI/GJA1/PBLD/JAM3/P2RX7/CA2 6 GO:0030900 forebrain development 7/255 379/18722 0.259683801298599 0.577097913516403 TACC2/GLI3/ISL1/LRP2/DISC1/NRP2/ZNF335 7 GO:0016055 Wnt signaling pathway 8/255 444/18722 0.260031738512155 0.577097913516403 RNF43/GLI3/ISL1/ITGA3/PLPP3/DISC1/KANK1/CTNND1 8 GO:0099111 microtubule-based transport 4/255 190/18722 0.260263424310729 0.577097913516403 CFAP53/TMEM201/TTLL1/DST 4 GO:0002220 innate immune response activating cell surface receptor signaling pathway 1/255 22/18722 0.260571249910927 0.577097913516403 PAK3 1 GO:0006907 pinocytosis 1/255 22/18722 0.260571249910927 0.577097913516403 NR1H3 1 GO:0009220 pyrimidine ribonucleotide biosynthetic process 1/255 22/18722 0.260571249910927 0.577097913516403 CTPS2 1 GO:0010866 regulation of triglyceride biosynthetic process 1/255 22/18722 0.260571249910927 0.577097913516403 NR1H3 1 GO:0021854 hypothalamus development 1/255 22/18722 0.260571249910927 0.577097913516403 NRP2 1 GO:0021904 dorsal/ventral neural tube patterning 1/255 22/18722 0.260571249910927 0.577097913516403 GLI3 1 GO:0030277 maintenance of gastrointestinal epithelium 1/255 22/18722 0.260571249910927 0.577097913516403 PBLD 1 GO:0032069 regulation of nuclease activity 1/255 22/18722 0.260571249910927 0.577097913516403 DDX11 1 GO:0032727 positive regulation of interferon-alpha production 1/255 22/18722 0.260571249910927 0.577097913516403 TLR3 1 GO:0035357 peroxisome proliferator activated receptor signaling pathway 1/255 22/18722 0.260571249910927 0.577097913516403 TWIST1 1 GO:0035809 regulation of urine volume 1/255 22/18722 0.260571249910927 0.577097913516403 BTC 1 GO:0045061 thymic T cell selection 1/255 22/18722 0.260571249910927 0.577097913516403 GLI3 1 GO:0046058 cAMP metabolic process 1/255 22/18722 0.260571249910927 0.577097913516403 PDE10A 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/255 22/18722 0.260571249910927 0.577097913516403 IRS1 1 GO:0055093 response to hyperoxia 1/255 22/18722 0.260571249910927 0.577097913516403 ATG7 1 GO:0060343 trabecula formation 1/255 22/18722 0.260571249910927 0.577097913516403 FBN2 1 GO:0060563 neuroepithelial cell differentiation 1/255 22/18722 0.260571249910927 0.577097913516403 SERPINE1 1 GO:0061042 vascular wound healing 1/255 22/18722 0.260571249910927 0.577097913516403 SERPINE1 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/255 22/18722 0.260571249910927 0.577097913516403 ABCA1 1 GO:1900120 regulation of receptor binding 1/255 22/18722 0.260571249910927 0.577097913516403 ADAM15 1 GO:1901032 negative regulation of response to reactive oxygen species 1/255 22/18722 0.260571249910927 0.577097913516403 MET 1 GO:2000114 regulation of establishment of cell polarity 1/255 22/18722 0.260571249910927 0.577097913516403 KANK1 1 GO:2000193 positive regulation of fatty acid transport 1/255 22/18722 0.260571249910927 0.577097913516403 ACSL1 1 GO:2000773 negative regulation of cellular senescence 1/255 22/18722 0.260571249910927 0.577097913516403 TWIST1 1 GO:0032732 positive regulation of interleukin-1 production 2/255 73/18722 0.262103895301412 0.578631789916299 ISL1/P2RX7 2 GO:0061035 regulation of cartilage development 2/255 73/18722 0.262103895301412 0.578631789916299 GLI3/BMPR2 2 GO:0072089 stem cell proliferation 2/255 73/18722 0.262103895301412 0.578631789916299 GJA1/RNF43 2 GO:1904427 positive regulation of calcium ion transmembrane transport 2/255 73/18722 0.262103895301412 0.578631789916299 EHD3/PDPK1 2 GO:0043414 macromolecule methylation 6/255 316/18722 0.262189636646873 0.578631789916299 N6AMT1/PRMT7/TRMT61B/PLD6/SETD6/ZNF335 6 GO:0198738 cell-cell signaling by wnt 8/255 446/18722 0.263872932361638 0.580504395226328 RNF43/GLI3/ISL1/ITGA3/PLPP3/DISC1/KANK1/CTNND1 8 GO:0009101 glycoprotein biosynthetic process 6/255 317/18722 0.264485500432846 0.580504395226328 CHST3/ST3GAL6/B3GNT3/GALNT3/GBGT1/BMPR2 6 GO:0018022 peptidyl-lysine methylation 3/255 131/18722 0.264549419125392 0.580504395226328 N6AMT1/SETD6/ZNF335 3 GO:1904950 negative regulation of establishment of protein localization 3/255 131/18722 0.264549419125392 0.580504395226328 NR1H3/IRS1/RAB23 3 GO:0010822 positive regulation of mitochondrion organization 2/255 74/18722 0.267158850849405 0.580504395226328 PLD6/DNM1L 2 GO:0046470 phosphatidylcholine metabolic process 2/255 74/18722 0.267158850849405 0.580504395226328 NR1H3/PLB1 2 GO:0048844 artery morphogenesis 2/255 74/18722 0.267158850849405 0.580504395226328 LRP2/BMPR2 2 GO:0120192 tight junction assembly 2/255 74/18722 0.267158850849405 0.580504395226328 GJA1/CLDN19 2 GO:1903201 regulation of oxidative stress-induced cell death 2/255 74/18722 0.267158850849405 0.580504395226328 MET/ATG7 2 GO:0007204 positive regulation of cytosolic calcium ion concentration 6/255 319/18722 0.269092825009045 0.580504395226328 GJA1/CXCR2/GPR157/P2RX7/ITGAV/PDPK1 6 GO:0008202 steroid metabolic process 6/255 319/18722 0.269092825009045 0.580504395226328 SDR42E1/LRP2/ATP8B1/PBX1/STARD4/ABCA1 6 GO:1904951 positive regulation of establishment of protein localization 6/255 319/18722 0.269092825009045 0.580504395226328 GJA1/GLI3/ISL1/SIRT3/ADAM9/DNM1L 6 GO:0002758 innate immune response-activating signal transduction 1/255 23/18722 0.270654369230323 0.580504395226328 PAK3 1 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 1/255 23/18722 0.270654369230323 0.580504395226328 ENPEP 1 GO:0003323 type B pancreatic cell development 1/255 23/18722 0.270654369230323 0.580504395226328 PDPK1 1 GO:0006541 glutamine metabolic process 1/255 23/18722 0.270654369230323 0.580504395226328 CTPS2 1 GO:0006622 protein targeting to lysosome 1/255 23/18722 0.270654369230323 0.580504395226328 CLU 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/255 23/18722 0.270654369230323 0.580504395226328 CLDN19 1 GO:0021544 subpallium development 1/255 23/18722 0.270654369230323 0.580504395226328 GLI3 1 GO:0021871 forebrain regionalization 1/255 23/18722 0.270654369230323 0.580504395226328 GLI3 1 GO:0021895 cerebral cortex neuron differentiation 1/255 23/18722 0.270654369230323 0.580504395226328 ZNF335 1 GO:0030194 positive regulation of blood coagulation 1/255 23/18722 0.270654369230323 0.580504395226328 SERPINE1 1 GO:0030325 adrenal gland development 1/255 23/18722 0.270654369230323 0.580504395226328 PBX1 1 GO:0031338 regulation of vesicle fusion 1/255 23/18722 0.270654369230323 0.580504395226328 SYT1 1 GO:0035162 embryonic hemopoiesis 1/255 23/18722 0.270654369230323 0.580504395226328 PBX1 1 GO:0035640 exploration behavior 1/255 23/18722 0.270654369230323 0.580504395226328 ITGA3 1 GO:0035988 chondrocyte proliferation 1/255 23/18722 0.270654369230323 0.580504395226328 BMPR2 1 GO:0035994 response to muscle stretch 1/255 23/18722 0.270654369230323 0.580504395226328 PTK2 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/255 23/18722 0.270654369230323 0.580504395226328 NR1H3 1 GO:0045943 positive regulation of transcription by RNA polymerase I 1/255 23/18722 0.270654369230323 0.580504395226328 DDX11 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/255 23/18722 0.270654369230323 0.580504395226328 CHST3 1 GO:0051131 chaperone-mediated protein complex assembly 1/255 23/18722 0.270654369230323 0.580504395226328 CLU 1 GO:0051383 kinetochore organization 1/255 23/18722 0.270654369230323 0.580504395226328 KNTC1 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/255 23/18722 0.270654369230323 0.580504395226328 ADAM9 1 GO:0060384 innervation 1/255 23/18722 0.270654369230323 0.580504395226328 ISL1 1 GO:0060396 growth hormone receptor signaling pathway 1/255 23/18722 0.270654369230323 0.580504395226328 PTK2 1 GO:0071514 genetic imprinting 1/255 23/18722 0.270654369230323 0.580504395226328 PRMT7 1 GO:0090208 positive regulation of triglyceride metabolic process 1/255 23/18722 0.270654369230323 0.580504395226328 NR1H3 1 GO:1900048 positive regulation of hemostasis 1/255 23/18722 0.270654369230323 0.580504395226328 SERPINE1 1 GO:1904666 regulation of ubiquitin protein ligase activity 1/255 23/18722 0.270654369230323 0.580504395226328 DNM1L 1 GO:2000810 regulation of bicellular tight junction assembly 1/255 23/18722 0.270654369230323 0.580504395226328 GJA1 1 GO:0016042 lipid catabolic process 6/255 320/18722 0.271404073758968 0.581314414322671 ASAH2B/ACADS/IRS1/TWIST1/IDH1/PLD6 6 GO:0071496 cellular response to external stimulus 6/255 320/18722 0.271404073758968 0.581314414322671 TLR3/GJA1/ASGR1/ATG7/BMPR2/DNM1L 6 GO:0046887 positive regulation of hormone secretion 3/255 133/18722 0.271913451088613 0.581498945957254 GJA1/ISL1/SIRT3 3 GO:0043627 response to estrogen 2/255 75/18722 0.272213531611816 0.581498945957254 GLI3/CA2 2 GO:0045913 positive regulation of carbohydrate metabolic process 2/255 75/18722 0.272213531611816 0.581498945957254 IRS1/P2RX7 2 GO:0009259 ribonucleotide metabolic process 7/255 385/18722 0.272234546539348 0.581498945957254 PDE10A/CTPS2/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 7 GO:0032147 activation of protein kinase activity 3/255 134/18722 0.275603989318852 0.584194960334757 EFNA5/TLR3/PDPK1 3 GO:0042552 myelination 3/255 134/18722 0.275603989318852 0.584194960334757 JAM3/CLU/ITGB4 3 GO:0009100 glycoprotein metabolic process 7/255 387/18722 0.276454176535369 0.584194960334757 CHST3/ST3GAL6/B3GNT3/MANBA/GALNT3/GBGT1/BMPR2 7 GO:0001937 negative regulation of endothelial cell proliferation 2/255 76/18722 0.277267010865623 0.584194960334757 GJA1/PTPRM 2 GO:0006809 nitric oxide biosynthetic process 2/255 76/18722 0.277267010865623 0.584194960334757 SPR/CLU 2 GO:0021536 diencephalon development 2/255 76/18722 0.277267010865623 0.584194960334757 ISL1/NRP2 2 GO:0032543 mitochondrial translation 2/255 76/18722 0.277267010865623 0.584194960334757 YARS2/MRPS28 2 GO:0043536 positive regulation of blood vessel endothelial cell migration 2/255 76/18722 0.277267010865623 0.584194960334757 SP1/PDPK1 2 GO:0140029 exocytic process 2/255 76/18722 0.277267010865623 0.584194960334757 SYT1/RAB15 2 GO:0140115 export across plasma membrane 2/255 76/18722 0.277267010865623 0.584194960334757 GJA1/ABCA1 2 GO:0045664 regulation of neuron differentiation 4/255 196/18722 0.278307842149365 0.584194960334757 GLI3/ISL1/CASZ1/PBX1 4 GO:0045927 positive regulation of growth 5/255 259/18722 0.278519255540846 0.584194960334757 SYT1/S100A8/N6AMT1/DISC1/BMPR2 5 GO:0009581 detection of external stimulus 3/255 135/18722 0.279299653597458 0.584194960334757 EYS/TMC1/PTK2 3 GO:0001779 natural killer cell differentiation 1/255 24/18722 0.280600523347991 0.584194960334757 PBX1 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/255 24/18722 0.280600523347991 0.584194960334757 CXCR2 1 GO:0007035 vacuolar acidification 1/255 24/18722 0.280600523347991 0.584194960334757 CLN5 1 GO:0010155 regulation of proton transport 1/255 24/18722 0.280600523347991 0.584194960334757 TWIST1 1 GO:0016486 peptide hormone processing 1/255 24/18722 0.280600523347991 0.584194960334757 ENPEP 1 GO:0021697 cerebellar cortex formation 1/255 24/18722 0.280600523347991 0.584194960334757 TTLL1 1 GO:0031639 plasminogen activation 1/255 24/18722 0.280600523347991 0.584194960334757 SERPINE1 1 GO:0032528 microvillus organization 1/255 24/18722 0.280600523347991 0.584194960334757 ATP8B1 1 GO:0033032 regulation of myeloid cell apoptotic process 1/255 24/18722 0.280600523347991 0.584194960334757 CXCR2 1 GO:0035458 cellular response to interferon-beta 1/255 24/18722 0.280600523347991 0.584194960334757 TLR3 1 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/255 24/18722 0.280600523347991 0.584194960334757 ZCCHC3 1 GO:0044321 response to leptin 1/255 24/18722 0.280600523347991 0.584194960334757 LRP2 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/255 24/18722 0.280600523347991 0.584194960334757 BCAR1 1 GO:0050820 positive regulation of coagulation 1/255 24/18722 0.280600523347991 0.584194960334757 SERPINE1 1 GO:0051156 glucose 6-phosphate metabolic process 1/255 24/18722 0.280600523347991 0.584194960334757 SHPK 1 GO:0051647 nucleus localization 1/255 24/18722 0.280600523347991 0.584194960334757 TMEM201 1 GO:0051923 sulfation 1/255 24/18722 0.280600523347991 0.584194960334757 TPST2 1 GO:0070841 inclusion body assembly 1/255 24/18722 0.280600523347991 0.584194960334757 CLU 1 GO:0071378 cellular response to growth hormone stimulus 1/255 24/18722 0.280600523347991 0.584194960334757 PTK2 1 GO:0072530 purine-containing compound transmembrane transport 1/255 24/18722 0.280600523347991 0.584194960334757 SLC19A1 1 GO:1901984 negative regulation of protein acetylation 1/255 24/18722 0.280600523347991 0.584194960334757 TWIST1 1 GO:1903861 positive regulation of dendrite extension 1/255 24/18722 0.280600523347991 0.584194960334757 SYT1 1 GO:2000209 regulation of anoikis 1/255 24/18722 0.280600523347991 0.584194960334757 PTK2 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/255 24/18722 0.280600523347991 0.584194960334757 TWIST1 1 GO:2001026 regulation of endothelial cell chemotaxis 1/255 24/18722 0.280600523347991 0.584194960334757 MET 1 GO:0007492 endoderm development 2/255 77/18722 0.282318386987444 0.585204094318238 COL4A2/ITGAV 2 GO:0048644 muscle organ morphogenesis 2/255 77/18722 0.282318386987444 0.585204094318238 ISL1/LRP2 2 GO:1901983 regulation of protein acetylation 2/255 77/18722 0.282318386987444 0.585204094318238 ISL1/TWIST1 2 GO:0006631 fatty acid metabolic process 7/255 390/18722 0.28281524545271 0.585204094318238 NR1H3/ASAH2B/ACADS/IRS1/TWIST1/ACSL1/PRKAB1 7 GO:0051656 establishment of organelle localization 7/255 390/18722 0.28281524545271 0.585204094318238 GJA1/MYO5B/PARD3B/TMEM201/KATNB1/SPICE1/PDPK1 7 GO:0003158 endothelium development 3/255 136/18722 0.283000033001614 0.585204094318238 GJA1/MET/BMPR2 3 GO:0007272 ensheathment of neurons 3/255 136/18722 0.283000033001614 0.585204094318238 JAM3/CLU/ITGB4 3 GO:0008366 axon ensheathment 3/255 136/18722 0.283000033001614 0.585204094318238 JAM3/CLU/ITGB4 3 GO:0030879 mammary gland development 3/255 137/18722 0.286704721177849 0.585204094318238 DDR1/GLI3/KDM5B 3 GO:0055123 digestive system development 3/255 137/18722 0.286704721177849 0.585204094318238 COBL/GLI3/SLC4A2 3 GO:0090090 negative regulation of canonical Wnt signaling pathway 3/255 137/18722 0.286704721177849 0.585204094318238 GLI3/ISL1/CTNND1 3 GO:0032371 regulation of sterol transport 2/255 78/18722 0.287366782946361 0.585204094318238 NR1H3/ABCA1 2 GO:0032374 regulation of cholesterol transport 2/255 78/18722 0.287366782946361 0.585204094318238 NR1H3/ABCA1 2 GO:0034637 cellular carbohydrate biosynthetic process 2/255 78/18722 0.287366782946361 0.585204094318238 B3GNT3/IRS1 2 GO:0043297 apical junction assembly 2/255 78/18722 0.287366782946361 0.585204094318238 GJA1/CLDN19 2 GO:0007517 muscle organ development 6/255 327/18722 0.287714533616263 0.585204094318238 LAMA5/ISL1/SIX4/LRP2/TWIST1/USP19 6 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 1/255 25/18722 0.290411565520751 0.585204094318238 GJA1 1 GO:0003094 glomerular filtration 1/255 25/18722 0.290411565520751 0.585204094318238 GJA1 1 GO:0006658 phosphatidylserine metabolic process 1/255 25/18722 0.290411565520751 0.585204094318238 PTDSS2 1 GO:0007288 sperm axoneme assembly 1/255 25/18722 0.290411565520751 0.585204094318238 TTLL1 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/255 25/18722 0.290411565520751 0.585204094318238 CTPS2 1 GO:0010842 retina layer formation 1/255 25/18722 0.290411565520751 0.585204094318238 PTPRM 1 GO:0016540 protein autoprocessing 1/255 25/18722 0.290411565520751 0.585204094318238 PISD 1 GO:0030318 melanocyte differentiation 1/255 25/18722 0.290411565520751 0.585204094318238 GLI3 1 GO:0032878 regulation of establishment or maintenance of cell polarity 1/255 25/18722 0.290411565520751 0.585204094318238 KANK1 1 GO:0033233 regulation of protein sumoylation 1/255 25/18722 0.290411565520751 0.585204094318238 PIAS3 1 GO:0033622 integrin activation 1/255 25/18722 0.290411565520751 0.585204094318238 JAM3 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/255 25/18722 0.290411565520751 0.585204094318238 ACSL1 1 GO:0036315 cellular response to sterol 1/255 25/18722 0.290411565520751 0.585204094318238 ABCA1 1 GO:0042730 fibrinolysis 1/255 25/18722 0.290411565520751 0.585204094318238 SERPINE1 1 GO:0046039 GTP metabolic process 1/255 25/18722 0.290411565520751 0.585204094318238 RAB23 1 GO:0046949 fatty-acyl-CoA biosynthetic process 1/255 25/18722 0.290411565520751 0.585204094318238 ACSL1 1 GO:0048596 embryonic camera-type eye morphogenesis 1/255 25/18722 0.290411565520751 0.585204094318238 TWIST1 1 GO:0051204 protein insertion into mitochondrial membrane 1/255 25/18722 0.290411565520751 0.585204094318238 TIMM8A 1 GO:0051291 protein heterooligomerization 1/255 25/18722 0.290411565520751 0.585204094318238 SYT1 1 GO:0051788 response to misfolded protein 1/255 25/18722 0.290411565520751 0.585204094318238 CLU 1 GO:0060074 synapse maturation 1/255 25/18722 0.290411565520751 0.585204094318238 DISC1 1 GO:0061436 establishment of skin barrier 1/255 25/18722 0.290411565520751 0.585204094318238 MET 1 GO:0062009 secondary palate development 1/255 25/18722 0.290411565520751 0.585204094318238 ITGB8 1 GO:0071459 protein localization to chromosome, centromeric region 1/255 25/18722 0.290411565520751 0.585204094318238 KNTC1 1 GO:0072207 metanephric epithelium development 1/255 25/18722 0.290411565520751 0.585204094318238 CXCR2 1 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 1/255 25/18722 0.290411565520751 0.585204094318238 GJA1 1 GO:0120316 sperm flagellum assembly 1/255 25/18722 0.290411565520751 0.585204094318238 TTLL1 1 GO:0140448 signaling receptor ligand precursor processing 1/255 25/18722 0.290411565520751 0.585204094318238 ENPEP 1 GO:1900078 positive regulation of cellular response to insulin stimulus 1/255 25/18722 0.290411565520751 0.585204094318238 IRS1 1 GO:1903792 negative regulation of anion transport 1/255 25/18722 0.290411565520751 0.585204094318238 GABRE 1 GO:1904385 cellular response to angiotensin 1/255 25/18722 0.290411565520751 0.585204094318238 CA2 1 GO:2000311 regulation of AMPA receptor activity 1/255 25/18722 0.290411565520751 0.585204094318238 CNIH3 1 GO:0009582 detection of abiotic stimulus 3/255 138/18722 0.290413316369863 0.585204094318238 EYS/TMC1/PTK2 3 GO:0099003 vesicle-mediated transport in synapse 4/255 200/18722 0.290448496092028 0.585204094318238 SYT1/SNCG/SYT8/DNM1L 4 GO:0006029 proteoglycan metabolic process 2/255 79/18722 0.292411345805813 0.58840016461247 CHST3/BMPR2 2 GO:0032272 negative regulation of protein polymerization 2/255 79/18722 0.292411345805813 0.58840016461247 KANK4/KANK1 2 GO:0048638 regulation of developmental growth 6/255 330/18722 0.294769469757734 0.592763573354517 SEMA4G/SYT1/GJA1/SIX4/DISC1/BMPR2 6 GO:0019693 ribose phosphate metabolic process 7/255 396/18722 0.295643387833828 0.593531099737037 PDE10A/CTPS2/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 7 GO:0016570 histone modification 8/255 463/18722 0.297161320981826 0.593531099737037 ISL1/KDM5B/N6AMT1/TWIST1/PRMT7/SIRT3/SETD6/ZNF335 8 GO:0001570 vasculogenesis 2/255 80/18722 0.297451246234406 0.593531099737037 ITGB8/ITGAV 2 GO:0007422 peripheral nervous system development 2/255 80/18722 0.297451246234406 0.593531099737037 ISL1/ITGB4 2 GO:0009791 post-embryonic development 2/255 80/18722 0.297451246234406 0.593531099737037 FBN1/KDM5B 2 GO:0051303 establishment of chromosome localization 2/255 80/18722 0.297451246234406 0.593531099737037 KATNB1/SPICE1 2 GO:0001573 ganglioside metabolic process 1/255 26/18722 0.300089324027046 0.593531099737037 ITGB8 1 GO:0002407 dendritic cell chemotaxis 1/255 26/18722 0.300089324027046 0.593531099737037 CXCR2 1 GO:0002418 immune response to tumor cell 1/255 26/18722 0.300089324027046 0.593531099737037 ADAM15 1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1/255 26/18722 0.300089324027046 0.593531099737037 BHLHE40-AS1 1 GO:0006760 folic acid-containing compound metabolic process 1/255 26/18722 0.300089324027046 0.593531099737037 SLC19A1 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/255 26/18722 0.300089324027046 0.593531099737037 GABRE 1 GO:0031167 rRNA methylation 1/255 26/18722 0.300089324027046 0.593531099737037 TRMT61B 1 GO:0033598 mammary gland epithelial cell proliferation 1/255 26/18722 0.300089324027046 0.593531099737037 KDM5B 1 GO:0034063 stress granule assembly 1/255 26/18722 0.300089324027046 0.593531099737037 GRB7 1 GO:0045672 positive regulation of osteoclast differentiation 1/255 26/18722 0.300089324027046 0.593531099737037 CA2 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/255 26/18722 0.300089324027046 0.593531099737037 GLI3 1 GO:0046697 decidualization 1/255 26/18722 0.300089324027046 0.593531099737037 GJA1 1 GO:0048499 synaptic vesicle membrane organization 1/255 26/18722 0.300089324027046 0.593531099737037 SYT1 1 GO:0048668 collateral sprouting 1/255 26/18722 0.300089324027046 0.593531099737037 COBL 1 GO:0048843 negative regulation of axon extension involved in axon guidance 1/255 26/18722 0.300089324027046 0.593531099737037 SEMA4G 1 GO:0051560 mitochondrial calcium ion homeostasis 1/255 26/18722 0.300089324027046 0.593531099737037 DISC1 1 GO:0060219 camera-type eye photoreceptor cell differentiation 1/255 26/18722 0.300089324027046 0.593531099737037 NAGLU 1 GO:0097186 amelogenesis 1/255 26/18722 0.300089324027046 0.593531099737037 SLC4A2 1 GO:1901071 glucosamine-containing compound metabolic process 1/255 26/18722 0.300089324027046 0.593531099737037 CHST3 1 GO:1905523 positive regulation of macrophage migration 1/255 26/18722 0.300089324027046 0.593531099737037 PTK2 1 GO:0048284 organelle fusion 3/255 141/18722 0.30155859594736 0.594134345587478 SYT1/PLD6/DNM1L 3 GO:0000422 autophagy of mitochondrion 2/255 81/18722 0.302485678025497 0.594134345587478 ATG7/DNM1L 2 GO:0001523 retinoid metabolic process 2/255 81/18722 0.302485678025497 0.594134345587478 PLB1/LRP2 2 GO:0001942 hair follicle development 2/255 81/18722 0.302485678025497 0.594134345587478 LAMA5/INTU 2 GO:0008589 regulation of smoothened signaling pathway 2/255 81/18722 0.302485678025497 0.594134345587478 GLI3/INTU 2 GO:0021954 central nervous system neuron development 2/255 81/18722 0.302485678025497 0.594134345587478 DISC1/NRP2 2 GO:0046209 nitric oxide metabolic process 2/255 81/18722 0.302485678025497 0.594134345587478 SPR/CLU 2 GO:0051817 modulation of process of other organism involved in symbiotic interaction 2/255 81/18722 0.302485678025497 0.594134345587478 ATG7/SP1 2 GO:0061726 mitochondrion disassembly 2/255 81/18722 0.302485678025497 0.594134345587478 ATG7/DNM1L 2 GO:0071260 cellular response to mechanical stimulus 2/255 81/18722 0.302485678025497 0.594134345587478 TLR3/GJA1 2 GO:2001021 negative regulation of response to DNA damage stimulus 2/255 81/18722 0.302485678025497 0.594134345587478 CLU/TWIST1 2 GO:0007009 plasma membrane organization 3/255 142/18722 0.305278894413453 0.595819740036729 ATP8B1/CLU/P2RX7 3 GO:0050729 positive regulation of inflammatory response 3/255 142/18722 0.305278894413453 0.595819740036729 TLR3/S100A8/SERPINE1 3 GO:0050000 chromosome localization 2/255 82/18722 0.307513857625398 0.595819740036729 KATNB1/SPICE1 2 GO:0060395 SMAD protein signal transduction 2/255 82/18722 0.307513857625398 0.595819740036729 PBLD/BMPR2 2 GO:0072527 pyrimidine-containing compound metabolic process 2/255 82/18722 0.307513857625398 0.595819740036729 CTPS2/SLC19A2 2 GO:2001057 reactive nitrogen species metabolic process 2/255 82/18722 0.307513857625398 0.595819740036729 SPR/CLU 2 GO:0017038 protein import 4/255 206/18722 0.308789244131252 0.595819740036729 TMCO6/GLI3/CLU/RAB23 4 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1/255 27/18722 0.309635602502287 0.595819740036729 PTK2 1 GO:0003401 axis elongation 1/255 27/18722 0.309635602502287 0.595819740036729 SIX4 1 GO:0007026 negative regulation of microtubule depolymerization 1/255 27/18722 0.309635602502287 0.595819740036729 KATNB1 1 GO:0010758 regulation of macrophage chemotaxis 1/255 27/18722 0.309635602502287 0.595819740036729 PTK2 1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 1/255 27/18722 0.309635602502287 0.595819740036729 PBX1 1 GO:0016556 mRNA modification 1/255 27/18722 0.309635602502287 0.595819740036729 TRMT61B 1 GO:0018126 protein hydroxylation 1/255 27/18722 0.309635602502287 0.595819740036729 P3H2 1 GO:0018195 peptidyl-arginine modification 1/255 27/18722 0.309635602502287 0.595819740036729 PRMT7 1 GO:0033561 regulation of water loss via skin 1/255 27/18722 0.309635602502287 0.595819740036729 MET 1 GO:0033688 regulation of osteoblast proliferation 1/255 27/18722 0.309635602502287 0.595819740036729 ITGAV 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/255 27/18722 0.309635602502287 0.595819740036729 NR1H3 1 GO:0034377 plasma lipoprotein particle assembly 1/255 27/18722 0.309635602502287 0.595819740036729 ABCA1 1 GO:0034505 tooth mineralization 1/255 27/18722 0.309635602502287 0.595819740036729 SLC4A2 1 GO:0034698 response to gonadotropin 1/255 27/18722 0.309635602502287 0.595819740036729 ITGA3 1 GO:0035116 embryonic hindlimb morphogenesis 1/255 27/18722 0.309635602502287 0.595819740036729 TWIST1 1 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 1/255 27/18722 0.309635602502287 0.595819740036729 PTK2 1 GO:0039529 RIG-I signaling pathway 1/255 27/18722 0.309635602502287 0.595819740036729 ZCCHC3 1 GO:0046337 phosphatidylethanolamine metabolic process 1/255 27/18722 0.309635602502287 0.595819740036729 PISD 1 GO:0048520 positive regulation of behavior 1/255 27/18722 0.309635602502287 0.595819740036729 GJA1 1 GO:0060142 regulation of syncytium formation by plasma membrane fusion 1/255 27/18722 0.309635602502287 0.595819740036729 ADAM9 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/255 27/18722 0.309635602502287 0.595819740036729 NR1H3 1 GO:1902883 negative regulation of response to oxidative stress 1/255 27/18722 0.309635602502287 0.595819740036729 MET 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/255 27/18722 0.309635602502287 0.595819740036729 ATG7 1 GO:1903205 regulation of hydrogen peroxide-induced cell death 1/255 27/18722 0.309635602502287 0.595819740036729 MET 1 GO:1903421 regulation of synaptic vesicle recycling 1/255 27/18722 0.309635602502287 0.595819740036729 DNM1L 1 GO:1903859 regulation of dendrite extension 1/255 27/18722 0.309635602502287 0.595819740036729 SYT1 1 GO:0051051 negative regulation of transport 8/255 470/18722 0.311155291336356 0.598375560262224 GJA1/NR1H3/PPP1R9A/GABRE/IRS1/TWIST1/RAB23/ITGAV 8 GO:0050886 endocrine process 2/255 83/18722 0.312535023670064 0.600286051867395 GJA1/ENPEP 2 GO:0061053 somite development 2/255 83/18722 0.312535023670064 0.600286051867395 COBL/SIX4 2 GO:0014065 phosphatidylinositol 3-kinase signaling 3/255 144/18722 0.312725021580838 0.600286051867395 IRS1/TWIST1/PTK2 3 GO:1901215 negative regulation of neuron death 4/255 208/18722 0.314930260849851 0.602439917427695 ISL1/SIX4/ATG7/PDPK1 4 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 5/255 273/18722 0.315521463857994 0.602439917427695 CLDN19/DSC3/CLSTN3/TENM3/PTPRM 5 GO:0007568 aging 6/255 339/18722 0.316131283268272 0.602439917427695 PPP1R9A/COL4A2/TWIST1/SERPINE1/ATG7/SIRT3 6 GO:0043524 negative regulation of neuron apoptotic process 3/255 145/18722 0.316450107547228 0.602439917427695 ISL1/SIX4/PDPK1 3 GO:0006970 response to osmotic stress 2/255 84/18722 0.317548436530109 0.602439917427695 TLR3/PDPK1 2 GO:0009953 dorsal/ventral pattern formation 2/255 84/18722 0.317548436530109 0.602439917427695 GLI3/INTU 2 GO:0010660 regulation of muscle cell apoptotic process 2/255 84/18722 0.317548436530109 0.602439917427695 CXCR2/PDPK1 2 GO:0022404 molting cycle process 2/255 84/18722 0.317548436530109 0.602439917427695 LAMA5/INTU 2 GO:0022405 hair cycle process 2/255 84/18722 0.317548436530109 0.602439917427695 LAMA5/INTU 2 GO:0042310 vasoconstriction 2/255 84/18722 0.317548436530109 0.602439917427695 GJA1/BMPR2 2 GO:0098586 cellular response to virus 2/255 84/18722 0.317548436530109 0.602439917427695 TLR3/ZCCHC3 2 GO:0006516 glycoprotein catabolic process 1/255 28/18722 0.319052180269707 0.602439917427695 MANBA 1 GO:0009312 oligosaccharide biosynthetic process 1/255 28/18722 0.319052180269707 0.602439917427695 ST3GAL6 1 GO:0010575 positive regulation of vascular endothelial growth factor production 1/255 28/18722 0.319052180269707 0.602439917427695 ISL1 1 GO:0032607 interferon-alpha production 1/255 28/18722 0.319052180269707 0.602439917427695 TLR3 1 GO:0032647 regulation of interferon-alpha production 1/255 28/18722 0.319052180269707 0.602439917427695 TLR3 1 GO:0032801 receptor catabolic process 1/255 28/18722 0.319052180269707 0.602439917427695 RNF43 1 GO:0038094 Fc-gamma receptor signaling pathway 1/255 28/18722 0.319052180269707 0.602439917427695 PTK2 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/255 28/18722 0.319052180269707 0.602439917427695 CTNND1 1 GO:0045589 regulation of regulatory T cell differentiation 1/255 28/18722 0.319052180269707 0.602439917427695 FANCA 1 GO:0070076 histone lysine demethylation 1/255 28/18722 0.319052180269707 0.602439917427695 KDM5B 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/255 28/18722 0.319052180269707 0.602439917427695 DNM1L 1 GO:0090344 negative regulation of cell aging 1/255 28/18722 0.319052180269707 0.602439917427695 TWIST1 1 GO:1903671 negative regulation of sprouting angiogenesis 1/255 28/18722 0.319052180269707 0.602439917427695 EPN2 1 GO:1903672 positive regulation of sprouting angiogenesis 1/255 28/18722 0.319052180269707 0.602439917427695 PDPK1 1 GO:1903779 regulation of cardiac conduction 1/255 28/18722 0.319052180269707 0.602439917427695 EHD3 1 GO:1990776 response to angiotensin 1/255 28/18722 0.319052180269707 0.602439917427695 CA2 1 GO:0043270 positive regulation of ion transport 5/255 275/18722 0.320864521596924 0.605496153375839 SYT1/EHD3/P2RX7/PRSS8/PDPK1 5 GO:0045637 regulation of myeloid cell differentiation 4/255 210/18722 0.321082073224827 0.60554102524296 TLR3/FBN1/PIAS3/CA2 4 GO:0071277 cellular response to calcium ion 2/255 85/18722 0.322553377864037 0.607216449292238 SYT1/SYT8 2 GO:0098773 skin epidermis development 2/255 85/18722 0.322553377864037 0.607216449292238 LAMA5/INTU 2 GO:2000779 regulation of double-strand break repair 2/255 85/18722 0.322553377864037 0.607216449292238 TWIST1/DDX11 2 GO:0001889 liver development 3/255 147/18722 0.323902502886312 0.607498543270424 COBL/MET/GLI3 3 GO:0060041 retina development in camera-type eye 3/255 147/18722 0.323902502886312 0.607498543270424 NAGLU/BMPR2/PTPRM 3 GO:1902850 microtubule cytoskeleton organization involved in mitosis 3/255 147/18722 0.323902502886312 0.607498543270424 GJA1/TACC2/SPICE1 3 GO:0042180 cellular ketone metabolic process 4/255 211/18722 0.324161490317224 0.607498543270424 NR1H3/IRS1/TWIST1/STARD4 4 GO:0006457 protein folding 4/255 212/18722 0.327242964466329 0.607498543270424 LMAN2L/CLU/RP2/HSPBP1 4 GO:0043523 regulation of neuron apoptotic process 4/255 212/18722 0.327242964466329 0.607498543270424 PAK3/ISL1/SIX4/PDPK1 4 GO:0006493 protein O-linked glycosylation 2/255 86/18722 0.327549150179507 0.607498543270424 B3GNT3/GALNT3 2 GO:0009798 axis specification 2/255 86/18722 0.327549150179507 0.607498543270424 COBL/PLD6 2 GO:0034103 regulation of tissue remodeling 2/255 86/18722 0.327549150179507 0.607498543270424 P2RX7/CA2 2 GO:0070507 regulation of microtubule cytoskeleton organization 3/255 148/18722 0.327629097936486 0.607498543270424 EFNA5/MET/KATNB1 3 GO:0000305 response to oxygen radical 1/255 29/18722 0.328340812666799 0.607498543270424 TXNRD2 1 GO:0001773 myeloid dendritic cell activation 1/255 29/18722 0.328340812666799 0.607498543270424 ITGB8 1 GO:0002068 glandular epithelial cell development 1/255 29/18722 0.328340812666799 0.607498543270424 PDPK1 1 GO:0003309 type B pancreatic cell differentiation 1/255 29/18722 0.328340812666799 0.607498543270424 PDPK1 1 GO:0005979 regulation of glycogen biosynthetic process 1/255 29/18722 0.328340812666799 0.607498543270424 IRS1 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/255 29/18722 0.328340812666799 0.607498543270424 CTPS2 1 GO:0010458 exit from mitosis 1/255 29/18722 0.328340812666799 0.607498543270424 KNTC1 1 GO:0010955 negative regulation of protein processing 1/255 29/18722 0.328340812666799 0.607498543270424 SERPINE1 1 GO:0010962 regulation of glucan biosynthetic process 1/255 29/18722 0.328340812666799 0.607498543270424 IRS1 1 GO:0022011 myelination in peripheral nervous system 1/255 29/18722 0.328340812666799 0.607498543270424 ITGB4 1 GO:0031069 hair follicle morphogenesis 1/255 29/18722 0.328340812666799 0.607498543270424 INTU 1 GO:0032292 peripheral nervous system axon ensheathment 1/255 29/18722 0.328340812666799 0.607498543270424 ITGB4 1 GO:0033028 myeloid cell apoptotic process 1/255 29/18722 0.328340812666799 0.607498543270424 CXCR2 1 GO:0035066 positive regulation of histone acetylation 1/255 29/18722 0.328340812666799 0.607498543270424 ISL1 1 GO:0042759 long-chain fatty acid biosynthetic process 1/255 29/18722 0.328340812666799 0.607498543270424 ASAH2B 1 GO:0090025 regulation of monocyte chemotaxis 1/255 29/18722 0.328340812666799 0.607498543270424 SERPINE1 1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/255 29/18722 0.328340812666799 0.607498543270424 CLU 1 GO:1902430 negative regulation of amyloid-beta formation 1/255 29/18722 0.328340812666799 0.607498543270424 CLU 1 GO:1903318 negative regulation of protein maturation 1/255 29/18722 0.328340812666799 0.607498543270424 SERPINE1 1 GO:0022898 regulation of transmembrane transporter activity 5/255 278/18722 0.328898956439656 0.608171147262678 EHD3/GJA1/CNIH3/TWIST1/KCNG1 5 GO:0051651 maintenance of location in cell 4/255 213/18722 0.330326284987647 0.610449225657242 GJA1/S100A8/KDELR3/PDPK1 4 GO:0051592 response to calcium ion 3/255 149/18722 0.331355489603205 0.611989305561475 SYT1/SYT8/ADAM9 3 GO:0001776 leukocyte homeostasis 2/255 87/18722 0.332535076402552 0.613080893072551 CXCR2/JAM3 2 GO:0016101 diterpenoid metabolic process 2/255 87/18722 0.332535076402552 0.613080893072551 PLB1/LRP2 2 GO:1903578 regulation of ATP metabolic process 2/255 87/18722 0.332535076402552 0.613080893072551 P2RX7/DNM1L 2 GO:0072330 monocarboxylic acid biosynthetic process 4/255 214/18722 0.333411242800876 0.613923347378062 NR1H3/ASAH2B/STARD4/PRKAB1 4 GO:0061008 hepaticobiliary system development 3/255 150/18722 0.335081332594939 0.613923347378062 COBL/MET/GLI3 3 GO:0000132 establishment of mitotic spindle orientation 1/255 30/18722 0.33750323136738 0.613923347378062 GJA1 1 GO:0006099 tricarboxylic acid cycle 1/255 30/18722 0.33750323136738 0.613923347378062 IDH1 1 GO:0006221 pyrimidine nucleotide biosynthetic process 1/255 30/18722 0.33750323136738 0.613923347378062 CTPS2 1 GO:0006884 cell volume homeostasis 1/255 30/18722 0.33750323136738 0.613923347378062 P2RX7 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/255 30/18722 0.33750323136738 0.613923347378062 BTC 1 GO:0010669 epithelial structure maintenance 1/255 30/18722 0.33750323136738 0.613923347378062 PBLD 1 GO:0015721 bile acid and bile salt transport 1/255 30/18722 0.33750323136738 0.613923347378062 ATP8B1 1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 1/255 30/18722 0.33750323136738 0.613923347378062 CTSF 1 GO:0030204 chondroitin sulfate metabolic process 1/255 30/18722 0.33750323136738 0.613923347378062 CHST3 1 GO:0034508 centromere complex assembly 1/255 30/18722 0.33750323136738 0.613923347378062 KNTC1 1 GO:0036296 response to increased oxygen levels 1/255 30/18722 0.33750323136738 0.613923347378062 ATG7 1 GO:0043304 regulation of mast cell degranulation 1/255 30/18722 0.33750323136738 0.613923347378062 PDPK1 1 GO:0045940 positive regulation of steroid metabolic process 1/255 30/18722 0.33750323136738 0.613923347378062 STARD4 1 GO:0048240 sperm capacitation 1/255 30/18722 0.33750323136738 0.613923347378062 CATSPER2 1 GO:0060292 long-term synaptic depression 1/255 30/18722 0.33750323136738 0.613923347378062 PPP1R9A 1 GO:0060674 placenta blood vessel development 1/255 30/18722 0.33750323136738 0.613923347378062 ITGB8 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/255 30/18722 0.33750323136738 0.613923347378062 TIMM8A 1 GO:0140058 neuron projection arborization 1/255 30/18722 0.33750323136738 0.613923347378062 LRP2 1 GO:1902751 positive regulation of cell cycle G2/M phase transition 1/255 30/18722 0.33750323136738 0.613923347378062 PBX1 1 GO:2000648 positive regulation of stem cell proliferation 1/255 30/18722 0.33750323136738 0.613923347378062 GJA1 1 GO:0031110 regulation of microtubule polymerization or depolymerization 2/255 88/18722 0.337510499454564 0.613923347378062 MET/KATNB1 2 GO:0006261 DNA-dependent DNA replication 3/255 151/18722 0.338806286369179 0.615563747037025 DDX11/ATG7/GMNN 3 GO:0055067 monovalent inorganic cation homeostasis 3/255 151/18722 0.338806286369179 0.615563747037025 SLC4A2/CLN5/CA2 3 GO:0009612 response to mechanical stimulus 4/255 216/18722 0.339585242115959 0.616620500646352 TLR3/GJA1/TMC1/PTK2 4 GO:0009199 ribonucleoside triphosphate metabolic process 2/255 89/18722 0.342474781836956 0.617412244689561 CTPS2/RAB23 2 GO:0010657 muscle cell apoptotic process 2/255 89/18722 0.342474781836956 0.617412244689561 CXCR2/PDPK1 2 GO:0051781 positive regulation of cell division 2/255 89/18722 0.342474781836956 0.617412244689561 GAREM1/BTC 2 GO:1900407 regulation of cellular response to oxidative stress 2/255 89/18722 0.342474781836956 0.617412244689561 MET/ATG7 2 GO:0031056 regulation of histone modification 3/255 152/18722 0.342530015130351 0.617412244689561 ISL1/TWIST1/ZNF335 3 GO:0051092 positive regulation of NF-kappaB transcription factor activity 3/255 152/18722 0.342530015130351 0.617412244689561 TLR3/S100A8/CLU 3 GO:0072503 cellular divalent inorganic cation homeostasis 8/255 486/18722 0.343617568619808 0.617412244689561 GJA1/CXCR2/GPR157/S100A8/DISC1/P2RX7/ITGAV/PDPK1 8 GO:0072659 protein localization to plasma membrane 5/255 284/18722 0.345025300105159 0.617412244689561 EHD3/LAMA5/ITGA3/RAB15/PDPK1 5 GO:0002063 chondrocyte development 1/255 31/18722 0.346541144699357 0.617412244689561 BMPR2 1 GO:0006613 cotranslational protein targeting to membrane 1/255 31/18722 0.346541144699357 0.617412244689561 BHLHE40-AS1 1 GO:0016577 histone demethylation 1/255 31/18722 0.346541144699357 0.617412244689561 KDM5B 1 GO:0018200 peptidyl-glutamic acid modification 1/255 31/18722 0.346541144699357 0.617412244689561 TTLL1 1 GO:0030149 sphingolipid catabolic process 1/255 31/18722 0.346541144699357 0.617412244689561 ASAH2B 1 GO:0031114 regulation of microtubule depolymerization 1/255 31/18722 0.346541144699357 0.617412244689561 KATNB1 1 GO:0032148 activation of protein kinase B activity 1/255 31/18722 0.346541144699357 0.617412244689561 PDPK1 1 GO:0033006 regulation of mast cell activation involved in immune response 1/255 31/18722 0.346541144699357 0.617412244689561 PDPK1 1 GO:0035115 embryonic forelimb morphogenesis 1/255 31/18722 0.346541144699357 0.617412244689561 TWIST1 1 GO:0036474 cell death in response to hydrogen peroxide 1/255 31/18722 0.346541144699357 0.617412244689561 MET 1 GO:0036475 neuron death in response to oxidative stress 1/255 31/18722 0.346541144699357 0.617412244689561 ATG7 1 GO:0043171 peptide catabolic process 1/255 31/18722 0.346541144699357 0.617412244689561 ENPEP 1 GO:0045066 regulatory T cell differentiation 1/255 31/18722 0.346541144699357 0.617412244689561 FANCA 1 GO:0048566 embryonic digestive tract development 1/255 31/18722 0.346541144699357 0.617412244689561 GLI3 1 GO:0051569 regulation of histone H3-K4 methylation 1/255 31/18722 0.346541144699357 0.617412244689561 ZNF335 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/255 31/18722 0.346541144699357 0.617412244689561 GJA1 1 GO:0060055 angiogenesis involved in wound healing 1/255 31/18722 0.346541144699357 0.617412244689561 SERPINE1 1 GO:0061117 negative regulation of heart growth 1/255 31/18722 0.346541144699357 0.617412244689561 GJA1 1 GO:0065005 protein-lipid complex assembly 1/255 31/18722 0.346541144699357 0.617412244689561 ABCA1 1 GO:0070633 transepithelial transport 1/255 31/18722 0.346541144699357 0.617412244689561 CLDN19 1 GO:0070723 response to cholesterol 1/255 31/18722 0.346541144699357 0.617412244689561 ABCA1 1 GO:0090183 regulation of kidney development 1/255 31/18722 0.346541144699357 0.617412244689561 SIX4 1 GO:1901797 negative regulation of signal transduction by p53 class mediator 1/255 31/18722 0.346541144699357 0.617412244689561 TWIST1 1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/255 31/18722 0.346541144699357 0.617412244689561 SERPINE1 1 GO:2000144 positive regulation of DNA-templated transcription, initiation 1/255 31/18722 0.346541144699357 0.617412244689561 TWIST1 1 GO:0002028 regulation of sodium ion transport 2/255 90/18722 0.34742730522335 0.617934165522464 P2RX7/PRSS8 2 GO:0006400 tRNA modification 2/255 90/18722 0.34742730522335 0.617934165522464 TYW1/TRMT61B 2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 2/255 90/18722 0.34742730522335 0.617934165522464 CLU/HSPBP1 2 GO:0006066 alcohol metabolic process 6/255 353/18722 0.349803075184437 0.621399996700776 PLB1/ASAH2B/SPR/PLPP3/IDH1/ABCA1 6 GO:0051480 regulation of cytosolic calcium ion concentration 6/255 353/18722 0.349803075184437 0.621399996700776 GJA1/CXCR2/GPR157/P2RX7/ITGAV/PDPK1 6 GO:0007605 sensory perception of sound 3/255 154/18722 0.349972478141877 0.621399996700776 TMC1/LRP2/ATP8B1 3 GO:0002064 epithelial cell development 4/255 220/18722 0.351943871067392 0.623344973972772 TMC1/ADAMTSL4/MET/PDPK1 4 GO:0002065 columnar/cuboidal epithelial cell differentiation 2/255 91/18722 0.35236747005917 0.623344973972772 SERPINE1/PDPK1 2 GO:0060191 regulation of lipase activity 2/255 91/18722 0.35236747005917 0.623344973972772 NR1H3/PDPK1 2 GO:0072594 establishment of protein localization to organelle 7/255 422/18722 0.352481460519378 0.623344973972772 TMCO6/GLI3/BHLHE40-AS1/TIMM8A/CLU/RAB23/TOMM34 7 GO:0006606 protein import into nucleus 3/255 155/18722 0.353690564494213 0.623344973972772 TMCO6/GLI3/RAB23 3 GO:0007519 skeletal muscle tissue development 3/255 155/18722 0.353690564494213 0.623344973972772 SIX4/TWIST1/USP19 3 GO:0003180 aortic valve morphogenesis 1/255 32/18722 0.355456237958234 0.623344973972772 TWIST1 1 GO:0003338 metanephros morphogenesis 1/255 32/18722 0.355456237958234 0.623344973972772 FRAS1 1 GO:0010644 cell communication by electrical coupling 1/255 32/18722 0.355456237958234 0.623344973972772 GJA1 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/255 32/18722 0.355456237958234 0.623344973972772 PDPK1 1 GO:0014044 Schwann cell development 1/255 32/18722 0.355456237958234 0.623344973972772 ITGB4 1 GO:0019934 cGMP-mediated signaling 1/255 32/18722 0.355456237958234 0.623344973972772 PDE10A 1 GO:0033687 osteoblast proliferation 1/255 32/18722 0.355456237958234 0.623344973972772 ITGAV 1 GO:0035456 response to interferon-beta 1/255 32/18722 0.355456237958234 0.623344973972772 TLR3 1 GO:0035767 endothelial cell chemotaxis 1/255 32/18722 0.355456237958234 0.623344973972772 MET 1 GO:0035883 enteroendocrine cell differentiation 1/255 32/18722 0.355456237958234 0.623344973972772 PDPK1 1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1/255 32/18722 0.355456237958234 0.623344973972772 HEXIM2 1 GO:0045879 negative regulation of smoothened signaling pathway 1/255 32/18722 0.355456237958234 0.623344973972772 GLI3 1 GO:0050850 positive regulation of calcium-mediated signaling 1/255 32/18722 0.355456237958234 0.623344973972772 LMCD1 1 GO:0051642 centrosome localization 1/255 32/18722 0.355456237958234 0.623344973972772 PARD3B 1 GO:0090140 regulation of mitochondrial fission 1/255 32/18722 0.355456237958234 0.623344973972772 DNM1L 1 GO:2000191 regulation of fatty acid transport 1/255 32/18722 0.355456237958234 0.623344973972772 ACSL1 1 GO:0001708 cell fate specification 2/255 92/18722 0.357294695168514 0.626217567247114 GLI3/ISL1 2 GO:0001837 epithelial to mesenchymal transition 3/255 157/18722 0.361118862577715 0.62749823200873 ISL1/TWIST1/ADAM15 3 GO:0007030 Golgi organization 3/255 157/18722 0.361118862577715 0.62749823200873 EHD3/ATP8B1/LMAN2L 3 GO:0051017 actin filament bundle assembly 3/255 157/18722 0.361118862577715 0.62749823200873 PPP1R9A/MET/ARHGAP28 3 GO:0007589 body fluid secretion 2/255 93/18722 0.362208417368183 0.62749823200873 NR1H3/DDR1 2 GO:0097306 cellular response to alcohol 2/255 93/18722 0.362208417368183 0.62749823200873 ADAM15/ABCA1 2 GO:1902807 negative regulation of cell cycle G1/S phase transition 2/255 93/18722 0.362208417368183 0.62749823200873 WEE1/SUSD2 2 GO:0001881 receptor recycling 1/255 33/18722 0.364250173716428 0.62749823200873 EHD3 1 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/255 33/18722 0.364250173716428 0.62749823200873 PTK2 1 GO:0003382 epithelial cell morphogenesis 1/255 33/18722 0.364250173716428 0.62749823200873 MET 1 GO:0006336 DNA replication-independent nucleosome assembly 1/255 33/18722 0.364250173716428 0.62749823200873 HIRA 1 GO:0006482 protein demethylation 1/255 33/18722 0.364250173716428 0.62749823200873 KDM5B 1 GO:0006891 intra-Golgi vesicle-mediated transport 1/255 33/18722 0.364250173716428 0.62749823200873 COG6 1 GO:0008214 protein dealkylation 1/255 33/18722 0.364250173716428 0.62749823200873 KDM5B 1 GO:0018345 protein palmitoylation 1/255 33/18722 0.364250173716428 0.62749823200873 ZDHHC13 1 GO:0021696 cerebellar cortex morphogenesis 1/255 33/18722 0.364250173716428 0.62749823200873 TTLL1 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/255 33/18722 0.364250173716428 0.62749823200873 EPN2 1 GO:0031116 positive regulation of microtubule polymerization 1/255 33/18722 0.364250173716428 0.62749823200873 MET 1 GO:0033198 response to ATP 1/255 33/18722 0.364250173716428 0.62749823200873 P2RX7 1 GO:0036336 dendritic cell migration 1/255 33/18722 0.364250173716428 0.62749823200873 CXCR2 1 GO:0048730 epidermis morphogenesis 1/255 33/18722 0.364250173716428 0.62749823200873 INTU 1 GO:0050974 detection of mechanical stimulus involved in sensory perception 1/255 33/18722 0.364250173716428 0.62749823200873 TMC1 1 GO:0061842 microtubule organizing center localization 1/255 33/18722 0.364250173716428 0.62749823200873 PARD3B 1 GO:0071353 cellular response to interleukin-4 1/255 33/18722 0.364250173716428 0.62749823200873 SHPK 1 GO:0071539 protein localization to centrosome 1/255 33/18722 0.364250173716428 0.62749823200873 DISC1 1 GO:0099174 regulation of presynapse organization 1/255 33/18722 0.364250173716428 0.62749823200873 CLSTN3 1 GO:0110110 positive regulation of animal organ morphogenesis 1/255 33/18722 0.364250173716428 0.62749823200873 SIX4 1 GO:1900181 negative regulation of protein localization to nucleus 1/255 33/18722 0.364250173716428 0.62749823200873 RAB23 1 GO:1902992 negative regulation of amyloid precursor protein catabolic process 1/255 33/18722 0.364250173716428 0.62749823200873 CLU 1 GO:1903146 regulation of autophagy of mitochondrion 1/255 33/18722 0.364250173716428 0.62749823200873 DNM1L 1 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 1/255 33/18722 0.364250173716428 0.62749823200873 HEXIM2 1 GO:1905606 regulation of presynapse assembly 1/255 33/18722 0.364250173716428 0.62749823200873 CLSTN3 1 GO:0001738 morphogenesis of a polarized epithelium 2/255 94/18722 0.367108091088752 0.62824223741316 LAMA5/INTU 2 GO:1902414 protein localization to cell junction 2/255 94/18722 0.367108091088752 0.62824223741316 JAM3/CLSTN3 2 GO:1990830 cellular response to leukemia inhibitory factor 2/255 94/18722 0.367108091088752 0.62824223741316 KDM5B/NRP2 2 GO:0051170 import into nucleus 3/255 159/18722 0.368534603674513 0.62824223741316 TMCO6/GLI3/RAB23 3 GO:0006486 protein glycosylation 4/255 226/18722 0.370484606796284 0.62824223741316 ST3GAL6/B3GNT3/GALNT3/GBGT1 4 GO:0043413 macromolecule glycosylation 4/255 226/18722 0.370484606796284 0.62824223741316 ST3GAL6/B3GNT3/GALNT3/GBGT1 4 GO:0006942 regulation of striated muscle contraction 2/255 95/18722 0.371993188002551 0.62824223741316 EHD3/TNNT3 2 GO:0008585 female gonad development 2/255 95/18722 0.371993188002551 0.62824223741316 FANCA/IDH1 2 GO:0032479 regulation of type I interferon production 2/255 95/18722 0.371993188002551 0.62824223741316 TLR3/ZCCHC3 2 GO:0032606 type I interferon production 2/255 95/18722 0.371993188002551 0.62824223741316 TLR3/ZCCHC3 2 GO:0036473 cell death in response to oxidative stress 2/255 95/18722 0.371993188002551 0.62824223741316 MET/ATG7 2 GO:0048709 oligodendrocyte differentiation 2/255 95/18722 0.371993188002551 0.62824223741316 GLI3/CLU 2 GO:1990823 response to leukemia inhibitory factor 2/255 95/18722 0.371993188002551 0.62824223741316 KDM5B/NRP2 2 GO:0000038 very long-chain fatty acid metabolic process 1/255 34/18722 0.372924592128452 0.62824223741316 ACSL1 1 GO:0001662 behavioral fear response 1/255 34/18722 0.372924592128452 0.62824223741316 GJA1 1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 1/255 34/18722 0.372924592128452 0.62824223741316 CTSF 1 GO:0006356 regulation of transcription by RNA polymerase I 1/255 34/18722 0.372924592128452 0.62824223741316 DDX11 1 GO:0009112 nucleobase metabolic process 1/255 34/18722 0.372924592128452 0.62824223741316 CTPS2 1 GO:0009303 rRNA transcription 1/255 34/18722 0.372924592128452 0.62824223741316 DDX11 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/255 34/18722 0.372924592128452 0.62824223741316 CXCR2 1 GO:0014072 response to isoquinoline alkaloid 1/255 34/18722 0.372924592128452 0.62824223741316 ATG7 1 GO:0016242 negative regulation of macroautophagy 1/255 34/18722 0.372924592128452 0.62824223741316 LZTS1 1 GO:0034724 DNA replication-independent nucleosome organization 1/255 34/18722 0.372924592128452 0.62824223741316 HIRA 1 GO:0035137 hindlimb morphogenesis 1/255 34/18722 0.372924592128452 0.62824223741316 TWIST1 1 GO:0035590 purinergic nucleotide receptor signaling pathway 1/255 34/18722 0.372924592128452 0.62824223741316 P2RX7 1 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1/255 34/18722 0.372924592128452 0.62824223741316 ZCCHC3 1 GO:0043276 anoikis 1/255 34/18722 0.372924592128452 0.62824223741316 PTK2 1 GO:0043278 response to morphine 1/255 34/18722 0.372924592128452 0.62824223741316 ATG7 1 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 1/255 34/18722 0.372924592128452 0.62824223741316 TWIST1 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/255 34/18722 0.372924592128452 0.62824223741316 ITGAV 1 GO:0048536 spleen development 1/255 34/18722 0.372924592128452 0.62824223741316 PBX1 1 GO:0048854 brain morphogenesis 1/255 34/18722 0.372924592128452 0.62824223741316 ZNF335 1 GO:0050931 pigment cell differentiation 1/255 34/18722 0.372924592128452 0.62824223741316 GLI3 1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 1/255 34/18722 0.372924592128452 0.62824223741316 GPR157 1 GO:0055094 response to lipoprotein particle 1/255 34/18722 0.372924592128452 0.62824223741316 ABCA1 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/255 34/18722 0.372924592128452 0.62824223741316 LMCD1 1 GO:0086019 cell-cell signaling involved in cardiac conduction 1/255 34/18722 0.372924592128452 0.62824223741316 GJA1 1 GO:0098751 bone cell development 1/255 34/18722 0.372924592128452 0.62824223741316 FBN1 1 GO:1990000 amyloid fibril formation 1/255 34/18722 0.372924592128452 0.62824223741316 CLU 1 GO:2000758 positive regulation of peptidyl-lysine acetylation 1/255 34/18722 0.372924592128452 0.62824223741316 ISL1 1 GO:2000780 negative regulation of double-strand break repair 1/255 34/18722 0.372924592128452 0.62824223741316 TWIST1 1 GO:0046777 protein autophosphorylation 4/255 227/18722 0.373572584332689 0.628994787736882 DDR1/MAP3K9/PTK2/PDPK1 4 GO:0036294 cellular response to decreased oxygen levels 3/255 161/18722 0.375935384397286 0.630479687703707 TWIST1/USP19/DNM1L 3 GO:0061572 actin filament bundle organization 3/255 161/18722 0.375935384397286 0.630479687703707 PPP1R9A/MET/ARHGAP28 3 GO:0032259 methylation 6/255 364/18722 0.376479168188803 0.630479687703707 N6AMT1/PRMT7/TRMT61B/PLD6/SETD6/ZNF335 6 GO:0042632 cholesterol homeostasis 2/255 96/18722 0.376863196658451 0.630479687703707 NR1H3/ABCA1 2 GO:0043648 dicarboxylic acid metabolic process 2/255 96/18722 0.376863196658451 0.630479687703707 IDH1/SLC19A1 2 GO:0044264 cellular polysaccharide metabolic process 2/255 96/18722 0.376863196658451 0.630479687703707 B3GNT3/IRS1 2 GO:1904035 regulation of epithelial cell apoptotic process 2/255 96/18722 0.376863196658451 0.630479687703707 SERPINE1/PDPK1 2 GO:0034250 positive regulation of cellular amide metabolic process 3/255 162/18722 0.379629433959716 0.630479687703707 CLU/SIRT3/SP1 3 GO:0001569 branching involved in blood vessel morphogenesis 1/255 35/18722 0.381481111232007 0.630479687703707 PLXND1 1 GO:0002209 behavioral defense response 1/255 35/18722 0.381481111232007 0.630479687703707 GJA1 1 GO:0006471 protein ADP-ribosylation 1/255 35/18722 0.381481111232007 0.630479687703707 SIRT3 1 GO:0010664 negative regulation of striated muscle cell apoptotic process 1/255 35/18722 0.381481111232007 0.630479687703707 PDPK1 1 GO:0010765 positive regulation of sodium ion transport 1/255 35/18722 0.381481111232007 0.630479687703707 PRSS8 1 GO:0010837 regulation of keratinocyte proliferation 1/255 35/18722 0.381481111232007 0.630479687703707 INTU 1 GO:0015695 organic cation transport 1/255 35/18722 0.381481111232007 0.630479687703707 SLC19A2 1 GO:0031076 embryonic camera-type eye development 1/255 35/18722 0.381481111232007 0.630479687703707 TWIST1 1 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 1/255 35/18722 0.381481111232007 0.630479687703707 ISL1 1 GO:0040001 establishment of mitotic spindle localization 1/255 35/18722 0.381481111232007 0.630479687703707 GJA1 1 GO:0042462 eye photoreceptor cell development 1/255 35/18722 0.381481111232007 0.630479687703707 NAGLU 1 GO:0043243 positive regulation of protein-containing complex disassembly 1/255 35/18722 0.381481111232007 0.630479687703707 KATNB1 1 GO:0044273 sulfur compound catabolic process 1/255 35/18722 0.381481111232007 0.630479687703707 GNS 1 GO:0045454 cell redox homeostasis 1/255 35/18722 0.381481111232007 0.630479687703707 TXNRD2 1 GO:0045880 positive regulation of smoothened signaling pathway 1/255 35/18722 0.381481111232007 0.630479687703707 INTU 1 GO:0045907 positive regulation of vasoconstriction 1/255 35/18722 0.381481111232007 0.630479687703707 GJA1 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/255 35/18722 0.381481111232007 0.630479687703707 CHST3 1 GO:0070536 protein K63-linked deubiquitination 1/255 35/18722 0.381481111232007 0.630479687703707 USP27X 1 GO:0072528 pyrimidine-containing compound biosynthetic process 1/255 35/18722 0.381481111232007 0.630479687703707 CTPS2 1 GO:0097421 liver regeneration 1/255 35/18722 0.381481111232007 0.630479687703707 GLI3 1 GO:0098801 regulation of renal system process 1/255 35/18722 0.381481111232007 0.630479687703707 GJA1 1 GO:0106056 regulation of calcineurin-mediated signaling 1/255 35/18722 0.381481111232007 0.630479687703707 LMCD1 1 GO:1905508 protein localization to microtubule organizing center 1/255 35/18722 0.381481111232007 0.630479687703707 DISC1 1 GO:0006721 terpenoid metabolic process 2/255 97/18722 0.381717622123332 0.630479687703707 PLB1/LRP2 2 GO:0055092 sterol homeostasis 2/255 97/18722 0.381717622123332 0.630479687703707 NR1H3/ABCA1 2 GO:0070252 actin-mediated cell contraction 2/255 97/18722 0.381717622123332 0.630479687703707 GJA1/PARVA 2 GO:1901216 positive regulation of neuron death 2/255 97/18722 0.381717622123332 0.630479687703707 PAK3/CLU 2 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 2/255 97/18722 0.381717622123332 0.630479687703707 SERPINE1/ITGAV 2 GO:0006633 fatty acid biosynthetic process 3/255 163/18722 0.383318875911835 0.63279000909904 NR1H3/ASAH2B/PRKAB1 3 GO:1903706 regulation of hemopoiesis 6/255 367/18722 0.383768776938675 0.633198219605786 TLR3/FBN1/GLI3/FANCA/PIAS3/CA2 6 GO:0009150 purine ribonucleotide metabolic process 6/255 368/18722 0.386199058105882 0.636294594068302 PDE10A/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 6 GO:0032642 regulation of chemokine production 2/255 98/18722 0.386555985630132 0.636294594068302 TLR3/TWIST1 2 GO:1902882 regulation of response to oxidative stress 2/255 98/18722 0.386555985630132 0.636294594068302 MET/ATG7 2 GO:2001242 regulation of intrinsic apoptotic signaling pathway 3/255 164/18722 0.387003430709959 0.636294594068302 S100A8/CLU/DNM1L 3 GO:0050900 leukocyte migration 6/255 369/18722 0.388629389611356 0.636294594068302 CXCR2/S100A8/JAM3/SERPINE1/PTK2/DNM1L 6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1/255 36/18722 0.389921327245056 0.636294594068302 CTSF 1 GO:0002691 regulation of cellular extravasation 1/255 36/18722 0.389921327245056 0.636294594068302 JAM3 1 GO:0006699 bile acid biosynthetic process 1/255 36/18722 0.389921327245056 0.636294594068302 STARD4 1 GO:0007031 peroxisome organization 1/255 36/18722 0.389921327245056 0.636294594068302 DNM1L 1 GO:0036314 response to sterol 1/255 36/18722 0.389921327245056 0.636294594068302 ABCA1 1 GO:0038179 neurotrophin signaling pathway 1/255 36/18722 0.389921327245056 0.636294594068302 BCAR1 1 GO:0042119 neutrophil activation 1/255 36/18722 0.389921327245056 0.636294594068302 CXCR2 1 GO:0044060 regulation of endocrine process 1/255 36/18722 0.389921327245056 0.636294594068302 GJA1 1 GO:0045738 negative regulation of DNA repair 1/255 36/18722 0.389921327245056 0.636294594068302 TWIST1 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/255 36/18722 0.389921327245056 0.636294594068302 BTC 1 GO:0046466 membrane lipid catabolic process 1/255 36/18722 0.389921327245056 0.636294594068302 ASAH2B 1 GO:0070306 lens fiber cell differentiation 1/255 36/18722 0.389921327245056 0.636294594068302 KDM5B 1 GO:0070670 response to interleukin-4 1/255 36/18722 0.389921327245056 0.636294594068302 SHPK 1 GO:0070873 regulation of glycogen metabolic process 1/255 36/18722 0.389921327245056 0.636294594068302 IRS1 1 GO:0071402 cellular response to lipoprotein particle stimulus 1/255 36/18722 0.389921327245056 0.636294594068302 ABCA1 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/255 36/18722 0.389921327245056 0.636294594068302 CLU 1 GO:0032635 interleukin-6 production 3/255 165/18722 0.390682823398764 0.636345317755503 TLR3/ISL1/TWIST1 3 GO:0032675 regulation of interleukin-6 production 3/255 165/18722 0.390682823398764 0.636345317755503 TLR3/ISL1/TWIST1 3 GO:0000045 autophagosome assembly 2/255 99/18722 0.391377824232344 0.636345317755503 ATG7/RAB23 2 GO:0010717 regulation of epithelial to mesenchymal transition 2/255 99/18722 0.391377824232344 0.636345317755503 ISL1/TWIST1 2 GO:0021549 cerebellum development 2/255 99/18722 0.391377824232344 0.636345317755503 NAGLU/TTLL1 2 GO:0032602 chemokine production 2/255 99/18722 0.391377824232344 0.636345317755503 TLR3/TWIST1 2 GO:0060291 long-term synaptic potentiation 2/255 99/18722 0.391377824232344 0.636345317755503 PPP1R9A/MPP2 2 GO:0051090 regulation of DNA-binding transcription factor activity 7/255 440/18722 0.39250701593486 0.637849414870742 TLR3/S100A8/PLPP3/CLU/TWIST1/FANCA/SETD6 7 GO:0043112 receptor metabolic process 3/255 166/18722 0.394356783590663 0.638871302070892 EHD3/CXCR2/RNF43 3 GO:0060538 skeletal muscle organ development 3/255 166/18722 0.394356783590663 0.638871302070892 SIX4/TWIST1/USP19 3 GO:0006626 protein targeting to mitochondrion 2/255 100/18722 0.396182690464872 0.638871302070892 TIMM8A/TOMM34 2 GO:0006641 triglyceride metabolic process 2/255 100/18722 0.396182690464872 0.638871302070892 NR1H3/ACSL1 2 GO:0046545 development of primary female sexual characteristics 2/255 100/18722 0.396182690464872 0.638871302070892 FANCA/IDH1 2 GO:0034767 positive regulation of ion transmembrane transport 3/255 167/18722 0.398025045444208 0.638871302070892 EHD3/P2RX7/PDPK1 3 GO:0000154 rRNA modification 1/255 37/18722 0.398246814858912 0.638871302070892 TRMT61B 1 GO:0001990 regulation of systemic arterial blood pressure by hormone 1/255 37/18722 0.398246814858912 0.638871302070892 ENPEP 1 GO:0003016 respiratory system process 1/255 37/18722 0.398246814858912 0.638871302070892 TTLL1 1 GO:0006623 protein targeting to vacuole 1/255 37/18722 0.398246814858912 0.638871302070892 CLU 1 GO:0006904 vesicle docking involved in exocytosis 1/255 37/18722 0.398246814858912 0.638871302070892 RAB15 1 GO:0007340 acrosome reaction 1/255 37/18722 0.398246814858912 0.638871302070892 PLB1 1 GO:0021532 neural tube patterning 1/255 37/18722 0.398246814858912 0.638871302070892 GLI3 1 GO:0030513 positive regulation of BMP signaling pathway 1/255 37/18722 0.398246814858912 0.638871302070892 BMPR2 1 GO:0032570 response to progesterone 1/255 37/18722 0.398246814858912 0.638871302070892 NR1H3 1 GO:0032885 regulation of polysaccharide biosynthetic process 1/255 37/18722 0.398246814858912 0.638871302070892 IRS1 1 GO:0033260 nuclear DNA replication 1/255 37/18722 0.398246814858912 0.638871302070892 GMNN 1 GO:0033363 secretory granule organization 1/255 37/18722 0.398246814858912 0.638871302070892 ABCA1 1 GO:0042178 xenobiotic catabolic process 1/255 37/18722 0.398246814858912 0.638871302070892 ACSL1 1 GO:0043403 skeletal muscle tissue regeneration 1/255 37/18722 0.398246814858912 0.638871302070892 EYS 1 GO:0043687 post-translational protein modification 1/255 37/18722 0.398246814858912 0.638871302070892 ATG7 1 GO:0051294 establishment of spindle orientation 1/255 37/18722 0.398246814858912 0.638871302070892 GJA1 1 GO:0051954 positive regulation of amine transport 1/255 37/18722 0.398246814858912 0.638871302070892 SYT1 1 GO:0060416 response to growth hormone 1/255 37/18722 0.398246814858912 0.638871302070892 PTK2 1 GO:0097484 dendrite extension 1/255 37/18722 0.398246814858912 0.638871302070892 SYT1 1 GO:0090068 positive regulation of cell cycle process 4/255 236/18722 0.401292745678883 0.643427311568245 BTC/PBX1/DDX11/USP19 4 GO:0006937 regulation of muscle contraction 3/255 169/18722 0.405343433364957 0.644436719189838 EHD3/TNNT3/PPP1R12B 3 GO:0021543 pallium development 3/255 169/18722 0.405343433364957 0.644436719189838 TACC2/GLI3/DISC1 3 GO:0010522 regulation of calcium ion transport into cytosol 2/255 102/18722 0.405739791376285 0.644436719189838 P2RX7/PDPK1 2 GO:0032677 regulation of interleukin-8 production 2/255 102/18722 0.405739791376285 0.644436719189838 TLR3/SERPINE1 2 GO:0002478 antigen processing and presentation of exogenous peptide antigen 1/255 38/18722 0.406459127527414 0.644436719189838 CTSF 1 GO:0006882 cellular zinc ion homeostasis 1/255 38/18722 0.406459127527414 0.644436719189838 S100A8 1 GO:0007094 mitotic spindle assembly checkpoint signaling 1/255 38/18722 0.406459127527414 0.644436719189838 KNTC1 1 GO:0032941 secretion by tissue 1/255 38/18722 0.406459127527414 0.644436719189838 NR1H3 1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 1/255 38/18722 0.406459127527414 0.644436719189838 ISL1 1 GO:0035136 forelimb morphogenesis 1/255 38/18722 0.406459127527414 0.644436719189838 TWIST1 1 GO:0035337 fatty-acyl-CoA metabolic process 1/255 38/18722 0.406459127527414 0.644436719189838 ACSL1 1 GO:0042491 inner ear auditory receptor cell differentiation 1/255 38/18722 0.406459127527414 0.644436719189838 TMC1 1 GO:0042596 fear response 1/255 38/18722 0.406459127527414 0.644436719189838 GJA1 1 GO:0046676 negative regulation of insulin secretion 1/255 38/18722 0.406459127527414 0.644436719189838 IRS1 1 GO:0048246 macrophage chemotaxis 1/255 38/18722 0.406459127527414 0.644436719189838 PTK2 1 GO:0071173 spindle assembly checkpoint signaling 1/255 38/18722 0.406459127527414 0.644436719189838 KNTC1 1 GO:0071174 mitotic spindle checkpoint signaling 1/255 38/18722 0.406459127527414 0.644436719189838 KNTC1 1 GO:0071398 cellular response to fatty acid 1/255 38/18722 0.406459127527414 0.644436719189838 IRS1 1 GO:1901031 regulation of response to reactive oxygen species 1/255 38/18722 0.406459127527414 0.644436719189838 MET 1 GO:1901186 positive regulation of ERBB signaling pathway 1/255 38/18722 0.406459127527414 0.644436719189838 BTC 1 GO:1903580 positive regulation of ATP metabolic process 1/255 38/18722 0.406459127527414 0.644436719189838 P2RX7 1 GO:1903725 regulation of phospholipid metabolic process 1/255 38/18722 0.406459127527414 0.644436719189838 IDH1 1 GO:0006909 phagocytosis 5/255 308/18722 0.409763166758895 0.64934578910829 NR1H3/MET/ITGAV/PTK2/ABCA1 5 GO:0006874 cellular calcium ion homeostasis 7/255 448/18722 0.410338327620735 0.649511401212828 GJA1/CXCR2/GPR157/DISC1/P2RX7/ITGAV/PDPK1 7 GO:0032637 interleukin-8 production 2/255 103/18722 0.410491205566508 0.649511401212828 TLR3/SERPINE1 2 GO:1905037 autophagosome organization 2/255 103/18722 0.410491205566508 0.649511401212828 ATG7/RAB23 2 GO:0048469 cell maturation 3/255 171/18722 0.412635950473139 0.651066240865198 CATSPER2/CLN5/PLD6 3 GO:0002347 response to tumor cell 1/255 39/18722 0.414559797752233 0.651066240865198 ADAM15 1 GO:0016572 histone phosphorylation 1/255 39/18722 0.414559797752233 0.651066240865198 TWIST1 1 GO:0021587 cerebellum morphogenesis 1/255 39/18722 0.414559797752233 0.651066240865198 TTLL1 1 GO:0031577 spindle checkpoint signaling 1/255 39/18722 0.414559797752233 0.651066240865198 KNTC1 1 GO:0032728 positive regulation of interferon-beta production 1/255 39/18722 0.414559797752233 0.651066240865198 TLR3 1 GO:0046326 positive regulation of glucose import 1/255 39/18722 0.414559797752233 0.651066240865198 IRS1 1 GO:0046621 negative regulation of organ growth 1/255 39/18722 0.414559797752233 0.651066240865198 GJA1 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/255 39/18722 0.414559797752233 0.651066240865198 BHLHE41 1 GO:0086091 regulation of heart rate by cardiac conduction 1/255 39/18722 0.414559797752233 0.651066240865198 ISL1 1 GO:0090207 regulation of triglyceride metabolic process 1/255 39/18722 0.414559797752233 0.651066240865198 NR1H3 1 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 1/255 39/18722 0.414559797752233 0.651066240865198 EHD3 1 GO:0006892 post-Golgi vesicle-mediated transport 2/255 104/18722 0.415224005774189 0.651066240865198 EHD3/RP2 2 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 2/255 104/18722 0.415224005774189 0.651066240865198 CXCR2/GPR157 2 GO:0022600 digestive system process 2/255 104/18722 0.415224005774189 0.651066240865198 NR1H3/PBLD 2 GO:0032963 collagen metabolic process 2/255 104/18722 0.415224005774189 0.651066240865198 P3H2/ADAM15 2 GO:1901890 positive regulation of cell junction assembly 2/255 104/18722 0.415224005774189 0.651066240865198 CLDN19/CLSTN3 2 GO:1903076 regulation of protein localization to plasma membrane 2/255 104/18722 0.415224005774189 0.651066240865198 ITGA3/PDPK1 2 GO:0007219 Notch signaling pathway 3/255 172/18722 0.416271890500213 0.652381974831075 NOTCH3/EPN2/PSEN2 3 GO:0060047 heart contraction 4/255 241/18722 0.416606680614491 0.652579386927461 EHD3/GJA1/ISL1/DNM1L 4 GO:0006694 steroid biosynthetic process 3/255 173/18722 0.419900631285323 0.655084989202698 SDR42E1/PBX1/STARD4 3 GO:0010469 regulation of signaling receptor activity 3/255 173/18722 0.419900631285323 0.655084989202698 BTC/CNIH3/SERPINE1 3 GO:0040029 regulation of gene expression, epigenetic 2/255 105/18722 0.41993781706896 0.655084989202698 PRMT7/ZNF335 2 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 2/255 105/18722 0.41993781706896 0.655084989202698 COBL/P2RX7 2 GO:0007018 microtubule-based movement 6/255 382/18722 0.420186873541476 0.655084989202698 CFAP53/CATSPER2/TMEM201/TTLL1/DST/KATNB1 6 GO:0006730 one-carbon metabolic process 1/255 40/18722 0.42255033736435 0.655084989202698 CA2 1 GO:0009187 cyclic nucleotide metabolic process 1/255 40/18722 0.42255033736435 0.655084989202698 PDE10A 1 GO:0014037 Schwann cell differentiation 1/255 40/18722 0.42255033736435 0.655084989202698 ITGB4 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization 1/255 40/18722 0.42255033736435 0.655084989202698 KATNB1 1 GO:0031297 replication fork processing 1/255 40/18722 0.42255033736435 0.655084989202698 DDX11 1 GO:0032892 positive regulation of organic acid transport 1/255 40/18722 0.42255033736435 0.655084989202698 ACSL1 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/255 40/18722 0.42255033736435 0.655084989202698 PDPK1 1 GO:0035329 hippo signaling 1/255 40/18722 0.42255033736435 0.655084989202698 TEAD3 1 GO:0045429 positive regulation of nitric oxide biosynthetic process 1/255 40/18722 0.42255033736435 0.655084989202698 CLU 1 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 1/255 40/18722 0.42255033736435 0.655084989202698 KNTC1 1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 1/255 40/18722 0.42255033736435 0.655084989202698 PDPK1 1 GO:0055069 zinc ion homeostasis 1/255 40/18722 0.42255033736435 0.655084989202698 S100A8 1 GO:0060412 ventricular septum morphogenesis 1/255 40/18722 0.42255033736435 0.655084989202698 BMPR2 1 GO:2000142 regulation of DNA-templated transcription, initiation 1/255 40/18722 0.42255033736435 0.655084989202698 TWIST1 1 GO:2000781 positive regulation of double-strand break repair 1/255 40/18722 0.42255033736435 0.655084989202698 DDX11 1 GO:0006644 phospholipid metabolic process 6/255 383/18722 0.422608428234444 0.655084989202698 NR1H3/PLB1/PLPP3/PISD/IDH1/PTDSS2 6 GO:0048639 positive regulation of developmental growth 3/255 174/18722 0.423521938130608 0.656175536270773 SYT1/DISC1/BMPR2 3 GO:0002062 chondrocyte differentiation 2/255 106/18722 0.424632278094451 0.656556939283224 GLI3/BMPR2 2 GO:0046822 regulation of nucleocytoplasmic transport 2/255 106/18722 0.424632278094451 0.656556939283224 GLI3/RAB23 2 GO:0071887 leukocyte apoptotic process 2/255 106/18722 0.424632278094451 0.656556939283224 CXCR2/GLI3 2 GO:1905477 positive regulation of protein localization to membrane 2/255 106/18722 0.424632278094451 0.656556939283224 ITGA3/PDPK1 2 GO:0014706 striated muscle tissue development 6/255 384/18722 0.425028700214388 0.656556939283224 GJA1/ISL1/SIX4/LRP2/TWIST1/USP19 6 GO:0022412 cellular process involved in reproduction in multicellular organism 6/255 384/18722 0.425028700214388 0.656556939283224 JAM3/CATSPER2/TTLL1/FANCA/PRMT7/PLD6 6 GO:0006605 protein targeting 5/255 314/18722 0.425868844866106 0.657529713540801 BHLHE40-AS1/TIMM8A/CLU/KATNB1/TOMM34 5 GO:0003341 cilium movement 3/255 175/18722 0.42713558068067 0.658717308095282 CFAP53/CATSPER2/TTLL1 3 GO:0050954 sensory perception of mechanical stimulus 3/255 175/18722 0.42713558068067 0.658717308095282 TMC1/LRP2/ATP8B1 3 GO:0005976 polysaccharide metabolic process 2/255 107/18722 0.429307040770683 0.658717308095282 B3GNT3/IRS1 2 GO:0008637 apoptotic mitochondrial changes 2/255 107/18722 0.429307040770683 0.658717308095282 CLU/DNM1L 2 GO:0021761 limbic system development 2/255 107/18722 0.429307040770683 0.658717308095282 GLI3/NRP2 2 GO:0032526 response to retinoic acid 2/255 107/18722 0.429307040770683 0.658717308095282 GJA1/ABCA1 2 GO:0042303 molting cycle 2/255 107/18722 0.429307040770683 0.658717308095282 LAMA5/INTU 2 GO:0042633 hair cycle 2/255 107/18722 0.429307040770683 0.658717308095282 LAMA5/INTU 2 GO:0006418 tRNA aminoacylation for protein translation 1/255 41/18722 0.430432237801781 0.658717308095282 YARS2 1 GO:0007099 centriole replication 1/255 41/18722 0.430432237801781 0.658717308095282 SPICE1 1 GO:0010907 positive regulation of glucose metabolic process 1/255 41/18722 0.430432237801781 0.658717308095282 IRS1 1 GO:0030488 tRNA methylation 1/255 41/18722 0.430432237801781 0.658717308095282 TRMT61B 1 GO:0042307 positive regulation of protein import into nucleus 1/255 41/18722 0.430432237801781 0.658717308095282 GLI3 1 GO:0044786 cell cycle DNA replication 1/255 41/18722 0.430432237801781 0.658717308095282 GMNN 1 GO:0048286 lung alveolus development 1/255 41/18722 0.430432237801781 0.658717308095282 BMPR2 1 GO:1901385 regulation of voltage-gated calcium channel activity 1/255 41/18722 0.430432237801781 0.658717308095282 EHD3 1 GO:1904407 positive regulation of nitric oxide metabolic process 1/255 41/18722 0.430432237801781 0.658717308095282 CLU 1 GO:1905521 regulation of macrophage migration 1/255 41/18722 0.430432237801781 0.658717308095282 PTK2 1 GO:0031668 cellular response to extracellular stimulus 4/255 246/18722 0.431833016096048 0.660214371477568 ASGR1/ATG7/BMPR2/DNM1L 4 GO:0051402 neuron apoptotic process 4/255 246/18722 0.431833016096048 0.660214371477568 PAK3/ISL1/SIX4/PDPK1 4 GO:0022037 metencephalon development 2/255 108/18722 0.43396177000199 0.663144514061721 NAGLU/TTLL1 2 GO:0098739 import across plasma membrane 3/255 177/18722 0.434338973012517 0.663146141621637 LRP2/SLC19A1/ACSL1 3 GO:0055074 calcium ion homeostasis 7/255 460/18722 0.437026288903403 0.663146141621637 GJA1/CXCR2/GPR157/DISC1/P2RX7/ITGAV/PDPK1 7 GO:0048015 phosphatidylinositol-mediated signaling 3/255 178/18722 0.43792828353363 0.663146141621637 IRS1/TWIST1/PTK2 3 GO:0000266 mitochondrial fission 1/255 42/18722 0.438206970383578 0.663146141621637 DNM1L 1 GO:0006040 amino sugar metabolic process 1/255 42/18722 0.438206970383578 0.663146141621637 CHST3 1 GO:0009154 purine ribonucleotide catabolic process 1/255 42/18722 0.438206970383578 0.663146141621637 PDE10A 1 GO:0014003 oligodendrocyte development 1/255 42/18722 0.438206970383578 0.663146141621637 CLU 1 GO:0014912 negative regulation of smooth muscle cell migration 1/255 42/18722 0.438206970383578 0.663146141621637 SERPINE1 1 GO:0016601 Rac protein signal transduction 1/255 42/18722 0.438206970383578 0.663146141621637 ARHGAP24 1 GO:0021575 hindbrain morphogenesis 1/255 42/18722 0.438206970383578 0.663146141621637 TTLL1 1 GO:0030574 collagen catabolic process 1/255 42/18722 0.438206970383578 0.663146141621637 ADAM15 1 GO:0033003 regulation of mast cell activation 1/255 42/18722 0.438206970383578 0.663146141621637 PDPK1 1 GO:0045047 protein targeting to ER 1/255 42/18722 0.438206970383578 0.663146141621637 BHLHE40-AS1 1 GO:0051602 response to electrical stimulus 1/255 42/18722 0.438206970383578 0.663146141621637 DISC1 1 GO:0055090 acylglycerol homeostasis 1/255 42/18722 0.438206970383578 0.663146141621637 NR1H3 1 GO:0070328 triglyceride homeostasis 1/255 42/18722 0.438206970383578 0.663146141621637 NR1H3 1 GO:0071312 cellular response to alkaloid 1/255 42/18722 0.438206970383578 0.663146141621637 ATG7 1 GO:0090317 negative regulation of intracellular protein transport 1/255 42/18722 0.438206970383578 0.663146141621637 RAB23 1 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 1/255 42/18722 0.438206970383578 0.663146141621637 KNTC1 1 GO:2001222 regulation of neuron migration 1/255 42/18722 0.438206970383578 0.663146141621637 IGSF10 1 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 4/255 249/18722 0.44091874937398 0.665725015796945 TLR3/GJA1/PDPK1/ZDHHC13 4 GO:0045926 negative regulation of growth 4/255 249/18722 0.44091874937398 0.665725015796945 SEMA4G/GJA1/ADAM15/BMPR2 4 GO:0006941 striated muscle contraction 3/255 179/18722 0.441509051177566 0.665725015796945 EHD3/GJA1/TNNT3 3 GO:0007088 regulation of mitotic nuclear division 2/255 110/18722 0.443209850954302 0.665725015796945 BTC/KNTC1 2 GO:0030317 flagellated sperm motility 2/255 110/18722 0.443209850954302 0.665725015796945 CATSPER2/TTLL1 2 GO:0032611 interleukin-1 beta production 2/255 110/18722 0.443209850954302 0.665725015796945 ISL1/P2RX7 2 GO:0032651 regulation of interleukin-1 beta production 2/255 110/18722 0.443209850954302 0.665725015796945 ISL1/P2RX7 2 GO:0097722 sperm motility 2/255 110/18722 0.443209850954302 0.665725015796945 CATSPER2/TTLL1 2 GO:0071897 DNA biosynthetic process 3/255 180/18722 0.445081066857281 0.665725015796945 GJA1/PAK3/BMPR2 3 GO:0001709 cell fate determination 1/255 43/18722 0.445875986580162 0.665725015796945 ISL1 1 GO:0014002 astrocyte development 1/255 43/18722 0.445875986580162 0.665725015796945 S100A8 1 GO:0021983 pituitary gland development 1/255 43/18722 0.445875986580162 0.665725015796945 ISL1 1 GO:0030517 negative regulation of axon extension 1/255 43/18722 0.445875986580162 0.665725015796945 SEMA4G 1 GO:0033046 negative regulation of sister chromatid segregation 1/255 43/18722 0.445875986580162 0.665725015796945 KNTC1 1 GO:0033048 negative regulation of mitotic sister chromatid segregation 1/255 43/18722 0.445875986580162 0.665725015796945 KNTC1 1 GO:0033173 calcineurin-NFAT signaling cascade 1/255 43/18722 0.445875986580162 0.665725015796945 LMCD1 1 GO:0034142 toll-like receptor 4 signaling pathway 1/255 43/18722 0.445875986580162 0.665725015796945 NR1H3 1 GO:0036230 granulocyte activation 1/255 43/18722 0.445875986580162 0.665725015796945 CXCR2 1 GO:0045776 negative regulation of blood pressure 1/255 43/18722 0.445875986580162 0.665725015796945 BMPR2 1 GO:0045840 positive regulation of mitotic nuclear division 1/255 43/18722 0.445875986580162 0.665725015796945 BTC 1 GO:0045981 positive regulation of nucleotide metabolic process 1/255 43/18722 0.445875986580162 0.665725015796945 P2RX7 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/255 43/18722 0.445875986580162 0.665725015796945 GLI3 1 GO:0061383 trabecula morphogenesis 1/255 43/18722 0.445875986580162 0.665725015796945 FBN2 1 GO:0090278 negative regulation of peptide hormone secretion 1/255 43/18722 0.445875986580162 0.665725015796945 IRS1 1 GO:0140353 lipid export from cell 1/255 43/18722 0.445875986580162 0.665725015796945 KDM5B 1 GO:1900544 positive regulation of purine nucleotide metabolic process 1/255 43/18722 0.445875986580162 0.665725015796945 P2RX7 1 GO:1904591 positive regulation of protein import 1/255 43/18722 0.445875986580162 0.665725015796945 GLI3 1 GO:2000816 negative regulation of mitotic sister chromatid separation 1/255 43/18722 0.445875986580162 0.665725015796945 KNTC1 1 GO:0003015 heart process 4/255 251/18722 0.446952590724688 0.667013775556185 EHD3/GJA1/ISL1/DNM1L 4 GO:0006805 xenobiotic metabolic process 2/255 111/18722 0.447802594852508 0.667138533251003 N6AMT1/ACSL1 2 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 2/255 111/18722 0.447802594852508 0.667138533251003 TWIST1/PTK2 2 GO:0015718 monocarboxylic acid transport 2/255 111/18722 0.447802594852508 0.667138533251003 ATP8B1/SLC16A12 2 GO:0045017 glycerolipid biosynthetic process 4/255 252/18722 0.449962091278734 0.667138533251003 NR1H3/PISD/PTDSS2/ACSL1 4 GO:0090257 regulation of muscle system process 4/255 252/18722 0.449962091278734 0.667138533251003 EHD3/TNNT3/LMCD1/PPP1R12B 4 GO:0009260 ribonucleotide biosynthetic process 3/255 182/18722 0.452198026748117 0.667138533251003 CTPS2/SLC26A2/ACSL1 3 GO:0048017 inositol lipid-mediated signaling 3/255 182/18722 0.452198026748117 0.667138533251003 IRS1/TWIST1/PTK2 3 GO:0060401 cytosolic calcium ion transport 3/255 182/18722 0.452198026748117 0.667138533251003 PSEN2/P2RX7/PDPK1 3 GO:0001676 long-chain fatty acid metabolic process 2/255 112/18722 0.452374089113303 0.667138533251003 ASAH2B/ACSL1 2 GO:0002526 acute inflammatory response 2/255 112/18722 0.452374089113303 0.667138533251003 CXCR2/S100A8 2 GO:0009141 nucleoside triphosphate metabolic process 2/255 112/18722 0.452374089113303 0.667138533251003 CTPS2/RAB23 2 GO:0032609 interferon-gamma production 2/255 112/18722 0.452374089113303 0.667138533251003 TLR3/ISL1 2 GO:0032649 regulation of interferon-gamma production 2/255 112/18722 0.452374089113303 0.667138533251003 TLR3/ISL1 2 GO:0048640 negative regulation of developmental growth 2/255 112/18722 0.452374089113303 0.667138533251003 SEMA4G/GJA1 2 GO:0008544 epidermis development 5/255 324/18722 0.452517551716389 0.667138533251003 TMC1/LAMA5/SVEP1/INTU/ADAM9 5 GO:0001819 positive regulation of cytokine production 7/255 467/18722 0.452521437976472 0.667138533251003 TLR3/ISL1/CLU/TWIST1/ZCCHC3/SERPINE1/P2RX7 7 GO:0060828 regulation of canonical Wnt signaling pathway 4/255 253/18722 0.452966460206469 0.667138533251003 GLI3/ISL1/KANK1/CTNND1 4 GO:0002066 columnar/cuboidal epithelial cell development 1/255 44/18722 0.453440718280042 0.667138533251003 PDPK1 1 GO:0002792 negative regulation of peptide secretion 1/255 44/18722 0.453440718280042 0.667138533251003 IRS1 1 GO:0005978 glycogen biosynthetic process 1/255 44/18722 0.453440718280042 0.667138533251003 IRS1 1 GO:0006378 mRNA polyadenylation 1/255 44/18722 0.453440718280042 0.667138533251003 SYMPK 1 GO:0006775 fat-soluble vitamin metabolic process 1/255 44/18722 0.453440718280042 0.667138533251003 LRP2 1 GO:0007528 neuromuscular junction development 1/255 44/18722 0.453440718280042 0.667138533251003 SIX4 1 GO:0009250 glucan biosynthetic process 1/255 44/18722 0.453440718280042 0.667138533251003 IRS1 1 GO:0032881 regulation of polysaccharide metabolic process 1/255 44/18722 0.453440718280042 0.667138533251003 IRS1 1 GO:0043039 tRNA aminoacylation 1/255 44/18722 0.453440718280042 0.667138533251003 YARS2 1 GO:0044058 regulation of digestive system process 1/255 44/18722 0.453440718280042 0.667138533251003 NR1H3 1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 1/255 44/18722 0.453440718280042 0.667138533251003 PARD3B 1 GO:0048066 developmental pigmentation 1/255 44/18722 0.453440718280042 0.667138533251003 GLI3 1 GO:0048806 genitalia development 1/255 44/18722 0.453440718280042 0.667138533251003 LRP2 1 GO:0006163 purine nucleotide metabolic process 6/255 396/18722 0.453941757098317 0.667561407497524 PDE10A/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 6 GO:0002764 immune response-regulating signaling pathway 7/255 468/18722 0.454728931675648 0.668404473888241 TLR3/NR1H3/PAK3/BCAR1/ZCCHC3/PTK2/PDPK1 7 GO:0044344 cellular response to fibroblast growth factor stimulus 2/255 113/18722 0.456924059368706 0.670403653233472 KDM5B/GALNT3 2 GO:0055001 muscle cell development 3/255 184/18722 0.459277573145712 0.670403653233472 TNNT3/ISL1/SIX4 3 GO:2001257 regulation of cation channel activity 3/255 184/18722 0.459277573145712 0.670403653233472 EHD3/CNIH3/KCNG1 3 GO:0003009 skeletal muscle contraction 1/255 45/18722 0.460902578052961 0.670403653233472 TNNT3 1 GO:0006110 regulation of glycolytic process 1/255 45/18722 0.460902578052961 0.670403653233472 P2RX7 1 GO:0010824 regulation of centrosome duplication 1/255 45/18722 0.460902578052961 0.670403653233472 SPICE1 1 GO:0030850 prostate gland development 1/255 45/18722 0.460902578052961 0.670403653233472 GLI3 1 GO:0035307 positive regulation of protein dephosphorylation 1/255 45/18722 0.460902578052961 0.670403653233472 SYMPK 1 GO:0035384 thioester biosynthetic process 1/255 45/18722 0.460902578052961 0.670403653233472 ACSL1 1 GO:0042551 neuron maturation 1/255 45/18722 0.460902578052961 0.670403653233472 CLN5 1 GO:0043038 amino acid activation 1/255 45/18722 0.460902578052961 0.670403653233472 YARS2 1 GO:0043631 RNA polyadenylation 1/255 45/18722 0.460902578052961 0.670403653233472 SYMPK 1 GO:0048546 digestive tract morphogenesis 1/255 45/18722 0.460902578052961 0.670403653233472 GLI3 1 GO:0048599 oocyte development 1/255 45/18722 0.460902578052961 0.670403653233472 PLD6 1 GO:0051985 negative regulation of chromosome segregation 1/255 45/18722 0.460902578052961 0.670403653233472 KNTC1 1 GO:0071354 cellular response to interleukin-6 1/255 45/18722 0.460902578052961 0.670403653233472 ST3GAL6 1 GO:0071616 acyl-CoA biosynthetic process 1/255 45/18722 0.460902578052961 0.670403653233472 ACSL1 1 GO:0098534 centriole assembly 1/255 45/18722 0.460902578052961 0.670403653233472 SPICE1 1 GO:1901985 positive regulation of protein acetylation 1/255 45/18722 0.460902578052961 0.670403653233472 ISL1 1 GO:1904646 cellular response to amyloid-beta 1/255 45/18722 0.460902578052961 0.670403653233472 GJA1 1 GO:1905819 negative regulation of chromosome separation 1/255 45/18722 0.460902578052961 0.670403653233472 KNTC1 1 GO:2000273 positive regulation of signaling receptor activity 1/255 45/18722 0.460902578052961 0.670403653233472 BTC 1 GO:0007041 lysosomal transport 2/255 114/18722 0.461452242593663 0.670403653233472 EHD3/CLU 2 GO:1901800 positive regulation of proteasomal protein catabolic process 2/255 114/18722 0.461452242593663 0.670403653233472 CLU/HSPBP1 2 GO:1903008 organelle disassembly 2/255 114/18722 0.461452242593663 0.670403653233472 ATG7/DNM1L 2 GO:0034976 response to endoplasmic reticulum stress 4/255 256/18722 0.461947423531534 0.670499627745491 NR1H3/TMEM117/CLU/USP19 4 GO:1903522 regulation of blood circulation 4/255 256/18722 0.461947423531534 0.670499627745491 EHD3/GJA1/ISL1/BMPR2 4 GO:0002040 sprouting angiogenesis 3/255 185/18722 0.462802837195184 0.671117803357285 EPN2/PARVA/PDPK1 3 GO:0051896 regulation of protein kinase B signaling 3/255 185/18722 0.462802837195184 0.671117803357285 MET/LRP2/PTK2 3 GO:0071675 regulation of mononuclear cell migration 2/255 115/18722 0.465958386850167 0.671556561796585 SERPINE1/PTK2 2 GO:0090630 activation of GTPase activity 2/255 115/18722 0.465958386850167 0.671556561796585 EVI5/ARHGAP24 2 GO:0008217 regulation of blood pressure 3/255 186/18722 0.466318180996356 0.671556561796585 GJA1/ENPEP/BMPR2 3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 3/255 186/18722 0.466318180996356 0.671556561796585 TLR3/GJA1/ZDHHC13 3 GO:0001974 blood vessel remodeling 1/255 46/18722 0.468262959409523 0.671556561796585 BMPR2 1 GO:0006195 purine nucleotide catabolic process 1/255 46/18722 0.468262959409523 0.671556561796585 PDE10A 1 GO:0007019 microtubule depolymerization 1/255 46/18722 0.468262959409523 0.671556561796585 KATNB1 1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1/255 46/18722 0.468262959409523 0.671556561796585 TENM3 1 GO:0010828 positive regulation of glucose transmembrane transport 1/255 46/18722 0.468262959409523 0.671556561796585 IRS1 1 GO:0010830 regulation of myotube differentiation 1/255 46/18722 0.468262959409523 0.671556561796585 BHLHE41 1 GO:0031018 endocrine pancreas development 1/255 46/18722 0.468262959409523 0.671556561796585 PDPK1 1 GO:0031057 negative regulation of histone modification 1/255 46/18722 0.468262959409523 0.671556561796585 TWIST1 1 GO:0032924 activin receptor signaling pathway 1/255 46/18722 0.468262959409523 0.671556561796585 BMPR2 1 GO:0033047 regulation of mitotic sister chromatid segregation 1/255 46/18722 0.468262959409523 0.671556561796585 KNTC1 1 GO:0042398 cellular modified amino acid biosynthetic process 1/255 46/18722 0.468262959409523 0.671556561796585 PTDSS2 1 GO:0043300 regulation of leukocyte degranulation 1/255 46/18722 0.468262959409523 0.671556561796585 PDPK1 1 GO:0043462 regulation of ATPase activity 1/255 46/18722 0.468262959409523 0.671556561796585 TNNT3 1 GO:0043616 keratinocyte proliferation 1/255 46/18722 0.468262959409523 0.671556561796585 INTU 1 GO:0046839 phospholipid dephosphorylation 1/255 46/18722 0.468262959409523 0.671556561796585 PLPP3 1 GO:0061462 protein localization to lysosome 1/255 46/18722 0.468262959409523 0.671556561796585 CLU 1 GO:0071827 plasma lipoprotein particle organization 1/255 46/18722 0.468262959409523 0.671556561796585 ABCA1 1 GO:0072599 establishment of protein localization to endoplasmic reticulum 1/255 46/18722 0.468262959409523 0.671556561796585 BHLHE40-AS1 1 GO:1900271 regulation of long-term synaptic potentiation 1/255 46/18722 0.468262959409523 0.671556561796585 PPP1R9A 1 GO:2000107 negative regulation of leukocyte apoptotic process 1/255 46/18722 0.468262959409523 0.671556561796585 CXCR2 1 GO:0061136 regulation of proteasomal protein catabolic process 3/255 187/18722 0.469823423898324 0.673485412698285 CLU/HSPBP1/USP19 3 GO:0006720 isoprenoid metabolic process 2/255 116/18722 0.470442251036181 0.673754369609563 PLB1/LRP2 2 GO:0007006 mitochondrial membrane organization 2/255 116/18722 0.470442251036181 0.673754369609563 TIMM8A/CHCHD6 2 GO:0060537 muscle tissue development 6/255 403/18722 0.47066136825241 0.673759402560139 GJA1/ISL1/SIX4/LRP2/TWIST1/USP19 6 GO:0006575 cellular modified amino acid metabolic process 3/255 188/18722 0.473318389177347 0.674539317205709 IDH1/PTDSS2/SLC19A1 3 GO:0006260 DNA replication 4/255 260/18722 0.473842143334232 0.674539317205709 CDAN1/DDX11/ATG7/GMNN 4 GO:0051091 positive regulation of DNA-binding transcription factor activity 4/255 260/18722 0.473842143334232 0.674539317205709 TLR3/S100A8/PLPP3/CLU 4 GO:0014902 myotube differentiation 2/255 117/18722 0.474903604639314 0.674539317205709 SIX4/BHLHE41 2 GO:0001754 eye photoreceptor cell differentiation 1/255 47/18722 0.475523237057336 0.674539317205709 NAGLU 1 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 1/255 47/18722 0.475523237057336 0.674539317205709 ENPEP 1 GO:0007595 lactation 1/255 47/18722 0.475523237057336 0.674539317205709 DDR1 1 GO:0009261 ribonucleotide catabolic process 1/255 47/18722 0.475523237057336 0.674539317205709 PDE10A 1 GO:0019884 antigen processing and presentation of exogenous antigen 1/255 47/18722 0.475523237057336 0.674539317205709 CTSF 1 GO:0035315 hair cell differentiation 1/255 47/18722 0.475523237057336 0.674539317205709 TMC1 1 GO:0042311 vasodilation 1/255 47/18722 0.475523237057336 0.674539317205709 GJA1 1 GO:0043114 regulation of vascular permeability 1/255 47/18722 0.475523237057336 0.674539317205709 CXCR2 1 GO:0045581 negative regulation of T cell differentiation 1/255 47/18722 0.475523237057336 0.674539317205709 GLI3 1 GO:0045747 positive regulation of Notch signaling pathway 1/255 47/18722 0.475523237057336 0.674539317205709 EPN2 1 GO:0046677 response to antibiotic 1/255 47/18722 0.475523237057336 0.674539317205709 KDM5B 1 GO:0048483 autonomic nervous system development 1/255 47/18722 0.475523237057336 0.674539317205709 NRP2 1 GO:0051489 regulation of filopodium assembly 1/255 47/18722 0.475523237057336 0.674539317205709 PPP1R9A 1 GO:0090279 regulation of calcium ion import 1/255 47/18722 0.475523237057336 0.674539317205709 PSEN2 1 GO:0097028 dendritic cell differentiation 1/255 47/18722 0.475523237057336 0.674539317205709 ITGB8 1 GO:0120163 negative regulation of cold-induced thermogenesis 1/255 47/18722 0.475523237057336 0.674539317205709 NR1H3 1 GO:1990778 protein localization to cell periphery 5/255 333/18722 0.476219630014844 0.675220664154441 EHD3/LAMA5/ITGA3/RAB15/PDPK1 5 GO:0090305 nucleic acid phosphodiester bond hydrolysis 4/255 261/18722 0.476800709364834 0.675737966786896 EXO5/TSEN15/PLD6/EXD3 4 GO:0062012 regulation of small molecule metabolic process 5/255 334/18722 0.478833460626483 0.677897469791858 NR1H3/IRS1/TWIST1/STARD4/P2RX7 5 GO:0045446 endothelial cell differentiation 2/255 118/18722 0.479342227495141 0.677897469791858 MET/BMPR2 2 GO:0051101 regulation of DNA binding 2/255 118/18722 0.479342227495141 0.677897469791858 ISL1/TWIST1 2 GO:0071346 cellular response to interferon-gamma 2/255 118/18722 0.479342227495141 0.677897469791858 TLR3/NR1H3 2 GO:0009636 response to toxic substance 4/255 262/18722 0.479752984245571 0.677897469791858 ABTB2/PPP1R9A/TXNRD2/KDM5B 4 GO:0031330 negative regulation of cellular catabolic process 4/255 262/18722 0.479752984245571 0.677897469791858 LZTS1/MET/ATG7/USP19 4 GO:0009566 fertilization 3/255 190/18722 0.480276799398135 0.677897469791858 PLB1/CATSPER2/KDM5B 3 GO:0046390 ribose phosphate biosynthetic process 3/255 190/18722 0.480276799398135 0.677897469791858 CTPS2/SLC26A2/ACSL1 3 GO:0051216 cartilage development 3/255 190/18722 0.480276799398135 0.677897469791858 GLI3/ITGB8/BMPR2 3 GO:0015804 neutral amino acid transport 1/255 48/18722 0.482684767153742 0.678843338143764 SLC38A5 1 GO:0043303 mast cell degranulation 1/255 48/18722 0.482684767153742 0.678843338143764 PDPK1 1 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 1/255 48/18722 0.482684767153742 0.678843338143764 DDX11 1 GO:0045839 negative regulation of mitotic nuclear division 1/255 48/18722 0.482684767153742 0.678843338143764 KNTC1 1 GO:0048146 positive regulation of fibroblast proliferation 1/255 48/18722 0.482684767153742 0.678843338143764 BTC 1 GO:0097720 calcineurin-mediated signaling 1/255 48/18722 0.482684767153742 0.678843338143764 LMCD1 1 GO:1903053 regulation of extracellular matrix organization 1/255 48/18722 0.482684767153742 0.678843338143764 DDR1 1 GO:1905710 positive regulation of membrane permeability 1/255 48/18722 0.482684767153742 0.678843338143764 JAM3 1 GO:0007052 mitotic spindle organization 2/255 120/18722 0.488150450628922 0.680509236820733 TACC2/SPICE1 2 GO:0032411 positive regulation of transporter activity 2/255 120/18722 0.488150450628922 0.680509236820733 EHD3/NR1H3 2 GO:0071774 response to fibroblast growth factor 2/255 120/18722 0.488150450628922 0.680509236820733 KDM5B/GALNT3 2 GO:0072655 establishment of protein localization to mitochondrion 2/255 120/18722 0.488150450628922 0.680509236820733 TIMM8A/TOMM34 2 GO:0030522 intracellular receptor signaling pathway 4/255 265/18722 0.488570875523343 0.680509236820733 NR1H3/ISL1/TWIST1/ZCCHC3 4 GO:0002279 mast cell activation involved in immune response 1/255 49/18722 0.489748887555145 0.680509236820733 PDPK1 1 GO:0009395 phospholipid catabolic process 1/255 49/18722 0.489748887555145 0.680509236820733 IDH1 1 GO:0009994 oocyte differentiation 1/255 49/18722 0.489748887555145 0.680509236820733 PLD6 1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1/255 49/18722 0.489748887555145 0.680509236820733 BMPR2 1 GO:0018198 peptidyl-cysteine modification 1/255 49/18722 0.489748887555145 0.680509236820733 S100A8 1 GO:0030195 negative regulation of blood coagulation 1/255 49/18722 0.489748887555145 0.680509236820733 SERPINE1 1 GO:0034332 adherens junction organization 1/255 49/18722 0.489748887555145 0.680509236820733 JAM3 1 GO:0035088 establishment or maintenance of apical/basal cell polarity 1/255 49/18722 0.489748887555145 0.680509236820733 PARD3B 1 GO:0038084 vascular endothelial growth factor signaling pathway 1/255 49/18722 0.489748887555145 0.680509236820733 NRP2 1 GO:0042304 regulation of fatty acid biosynthetic process 1/255 49/18722 0.489748887555145 0.680509236820733 NR1H3 1 GO:0042461 photoreceptor cell development 1/255 49/18722 0.489748887555145 0.680509236820733 NAGLU 1 GO:0046605 regulation of centrosome cycle 1/255 49/18722 0.489748887555145 0.680509236820733 SPICE1 1 GO:0050832 defense response to fungus 1/255 49/18722 0.489748887555145 0.680509236820733 S100A8 1 GO:0052372 modulation by symbiont of entry into host 1/255 49/18722 0.489748887555145 0.680509236820733 ITGAV 1 GO:0060986 endocrine hormone secretion 1/255 49/18722 0.489748887555145 0.680509236820733 GJA1 1 GO:0061245 establishment or maintenance of bipolar cell polarity 1/255 49/18722 0.489748887555145 0.680509236820733 PARD3B 1 GO:0070741 response to interleukin-6 1/255 49/18722 0.489748887555145 0.680509236820733 ST3GAL6 1 GO:0072091 regulation of stem cell proliferation 1/255 49/18722 0.489748887555145 0.680509236820733 GJA1 1 GO:0072666 establishment of protein localization to vacuole 1/255 49/18722 0.489748887555145 0.680509236820733 CLU 1 GO:1901799 negative regulation of proteasomal protein catabolic process 1/255 49/18722 0.489748887555145 0.680509236820733 USP19 1 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/255 49/18722 0.489748887555145 0.680509236820733 SERPINE1 1 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 1/255 49/18722 0.489748887555145 0.680509236820733 GJA1 1 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 3/255 193/18722 0.490633136385996 0.681434911647217 EFNA5/BTC/ISL1 3 GO:0048545 response to steroid hormone 5/255 339/18722 0.491836568352559 0.682655749212821 NR1H3/ISL1/IDH1/ADAM9/CA2 5 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6/255 412/18722 0.491949039112727 0.682655749212821 CLU/KLHL42/RMND5B/HSPBP1/USP19/ZNF598 6 GO:0042752 regulation of circadian rhythm 2/255 121/18722 0.492519660206379 0.683144224653766 NR1H3/ATG7 2 GO:0000387 spliceosomal snRNP assembly 1/255 50/18722 0.496716918063014 0.683709485336179 PRMT7 1 GO:0002448 mast cell mediated immunity 1/255 50/18722 0.496716918063014 0.683709485336179 PDPK1 1 GO:0006220 pyrimidine nucleotide metabolic process 1/255 50/18722 0.496716918063014 0.683709485336179 CTPS2 1 GO:0007140 male meiotic nuclear division 1/255 50/18722 0.496716918063014 0.683709485336179 FANCA 1 GO:0018023 peptidyl-lysine trimethylation 1/255 50/18722 0.496716918063014 0.683709485336179 ZNF335 1 GO:0019083 viral transcription 1/255 50/18722 0.496716918063014 0.683709485336179 SP1 1 GO:0038093 Fc receptor signaling pathway 1/255 50/18722 0.496716918063014 0.683709485336179 PTK2 1 GO:0042572 retinol metabolic process 1/255 50/18722 0.496716918063014 0.683709485336179 PLB1 1 GO:0045058 T cell selection 1/255 50/18722 0.496716918063014 0.683709485336179 GLI3 1 GO:0046638 positive regulation of alpha-beta T cell differentiation 1/255 50/18722 0.496716918063014 0.683709485336179 GLI3 1 GO:0060688 regulation of morphogenesis of a branching structure 1/255 50/18722 0.496716918063014 0.683709485336179 SIX4 1 GO:0070231 T cell apoptotic process 1/255 50/18722 0.496716918063014 0.683709485336179 GLI3 1 GO:0071825 protein-lipid complex subunit organization 1/255 50/18722 0.496716918063014 0.683709485336179 ABCA1 1 GO:0099054 presynapse assembly 1/255 50/18722 0.496716918063014 0.683709485336179 CLSTN3 1 GO:1900047 negative regulation of hemostasis 1/255 50/18722 0.496716918063014 0.683709485336179 SERPINE1 1 GO:1901570 fatty acid derivative biosynthetic process 1/255 50/18722 0.496716918063014 0.683709485336179 ACSL1 1 GO:2000677 regulation of transcription regulatory region DNA binding 1/255 50/18722 0.496716918063014 0.683709485336179 TWIST1 1 GO:0031109 microtubule polymerization or depolymerization 2/255 122/18722 0.496865357183508 0.683709485336179 MET/KATNB1 2 GO:0030705 cytoskeleton-dependent intracellular transport 3/255 195/18722 0.497481336376441 0.684255799373407 MYO5B/TMEM201/DST 3 GO:0009117 nucleotide metabolic process 7/255 489/18722 0.500599416059757 0.688241608089195 PDE10A/CTPS2/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 7 GO:0071674 mononuclear cell migration 3/255 196/18722 0.500888178255619 0.688335777066319 CXCR2/SERPINE1/PTK2 3 GO:0072521 purine-containing compound metabolic process 6/255 416/18722 0.501322613530186 0.688629963640365 PDE10A/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 6 GO:0009584 detection of visible light 1/255 51/18722 0.503590160666588 0.689622809852361 EYS 1 GO:0009948 anterior/posterior axis specification 1/255 51/18722 0.503590160666588 0.689622809852361 PLD6 1 GO:0010656 negative regulation of muscle cell apoptotic process 1/255 51/18722 0.503590160666588 0.689622809852361 PDPK1 1 GO:0014009 glial cell proliferation 1/255 51/18722 0.503590160666588 0.689622809852361 CLU 1 GO:0045104 intermediate filament cytoskeleton organization 1/255 51/18722 0.503590160666588 0.689622809852361 DST 1 GO:0051293 establishment of spindle localization 1/255 51/18722 0.503590160666588 0.689622809852361 GJA1 1 GO:0060043 regulation of cardiac muscle cell proliferation 1/255 51/18722 0.503590160666588 0.689622809852361 GJA1 1 GO:0048167 regulation of synaptic plasticity 3/255 198/18722 0.507666630856189 0.694900666415064 LZTS1/PPP1R9A/MPP2 3 GO:0018210 peptidyl-threonine modification 2/255 125/18722 0.509759698335016 0.696465474593791 GALNT3/PDPK1 2 GO:0060294 cilium movement involved in cell motility 2/255 125/18722 0.509759698335016 0.696465474593791 CATSPER2/TTLL1 2 GO:1904375 regulation of protein localization to cell periphery 2/255 125/18722 0.509759698335016 0.696465474593791 ITGA3/PDPK1 2 GO:0035176 social behavior 1/255 52/18722 0.51036989978233 0.696465474593791 NRXN3 1 GO:0045103 intermediate filament-based process 1/255 52/18722 0.51036989978233 0.696465474593791 DST 1 GO:0072523 purine-containing compound catabolic process 1/255 52/18722 0.51036989978233 0.696465474593791 PDE10A 1 GO:2000378 negative regulation of reactive oxygen species metabolic process 1/255 52/18722 0.51036989978233 0.696465474593791 SIRT3 1 GO:0032102 negative regulation of response to external stimulus 6/255 420/18722 0.510636270492985 0.69652481243587 SEMA4G/GJA1/NR1H3/CLDN19/ISL1/SERPINE1 6 GO:0006936 muscle contraction 5/255 347/18722 0.512391882094644 0.698309913452142 EHD3/GJA1/TNNT3/SSPN/PPP1R12B 5 GO:0070482 response to oxygen levels 5/255 347/18722 0.512391882094644 0.698309913452142 TWIST1/ADAM15/ATG7/USP19/DNM1L 5 GO:2001235 positive regulation of apoptotic signaling pathway 2/255 126/18722 0.514009714848333 0.700209397951631 S100A8/DNM1L 2 GO:0071902 positive regulation of protein serine/threonine kinase activity 3/255 200/18722 0.514397196799753 0.700431912853694 BMPR2/ACSL1/ADAM9 3 GO:0016925 protein sumoylation 1/255 53/18722 0.517057402490177 0.701913285309211 PIAS3 1 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1/255 53/18722 0.517057402490177 0.701913285309211 MET 1 GO:0050819 negative regulation of coagulation 1/255 53/18722 0.517057402490177 0.701913285309211 SERPINE1 1 GO:0051438 regulation of ubiquitin-protein transferase activity 1/255 53/18722 0.517057402490177 0.701913285309211 DNM1L 1 GO:0099172 presynapse organization 1/255 53/18722 0.517057402490177 0.701913285309211 CLSTN3 1 GO:1990090 cellular response to nerve growth factor stimulus 1/255 53/18722 0.517057402490177 0.701913285309211 PDPK1 1 GO:2000772 regulation of cellular senescence 1/255 53/18722 0.517057402490177 0.701913285309211 TWIST1 1 GO:0065004 protein-DNA complex assembly 3/255 201/18722 0.517744193460505 0.702262387110971 HIRA/KNTC1/GMNN 3 GO:0006753 nucleoside phosphate metabolic process 7/255 497/18722 0.517764012769177 0.702262387110971 PDE10A/CTPS2/SLC26A2/RAB23/P2RX7/ACSL1/TPST2 7 GO:0000819 sister chromatid segregation 3/255 202/18722 0.521078830763714 0.705839335126401 DDX11/KNTC1/KATNB1 3 GO:0009913 epidermal cell differentiation 3/255 202/18722 0.521078830763714 0.705839335126401 TMC1/INTU/ADAM9 3 GO:0016051 carbohydrate biosynthetic process 3/255 202/18722 0.521078830763714 0.705839335126401 ST3GAL6/B3GNT3/IRS1 3 GO:0006639 acylglycerol metabolic process 2/255 128/18722 0.522436766142136 0.706266075159993 NR1H3/ACSL1 2 GO:0032612 interleukin-1 production 2/255 128/18722 0.522436766142136 0.706266075159993 ISL1/P2RX7 2 GO:0032652 regulation of interleukin-1 production 2/255 128/18722 0.522436766142136 0.706266075159993 ISL1/P2RX7 2 GO:0030520 intracellular estrogen receptor signaling pathway 1/255 54/18722 0.523653918766625 0.706266075159993 ISL1 1 GO:0032330 regulation of chondrocyte differentiation 1/255 54/18722 0.523653918766625 0.706266075159993 GLI3 1 GO:0051703 biological process involved in intraspecies interaction between organisms 1/255 54/18722 0.523653918766625 0.706266075159993 NRXN3 1 GO:0060350 endochondral bone morphogenesis 1/255 54/18722 0.523653918766625 0.706266075159993 BMPR2 1 GO:0072698 protein localization to microtubule cytoskeleton 1/255 54/18722 0.523653918766625 0.706266075159993 DISC1 1 GO:0086002 cardiac muscle cell action potential involved in contraction 1/255 54/18722 0.523653918766625 0.706266075159993 GJA1 1 GO:1902743 regulation of lamellipodium organization 1/255 54/18722 0.523653918766625 0.706266075159993 KANK1 1 GO:0051701 biological process involved in interaction with host 3/255 203/18722 0.524400986584317 0.706968543173421 ATG7/ITGAV/SLC52A1 3 GO:0006887 exocytosis 5/255 352/18722 0.525067237952542 0.707561500043852 SYT1/RAB15/SYT8/PDPK1/DNM1L 5 GO:0007281 germ cell development 4/255 278/18722 0.526041779681501 0.708569207545125 JAM3/CATSPER2/TTLL1/PLD6 4 GO:0006638 neutral lipid metabolic process 2/255 129/18722 0.526613550880626 0.709033755494164 NR1H3/ACSL1 2 GO:0000768 syncytium formation by plasma membrane fusion 1/255 55/18722 0.530160681714692 0.709731611153547 ADAM9 1 GO:0002067 glandular epithelial cell differentiation 1/255 55/18722 0.530160681714692 0.709731611153547 PDPK1 1 GO:0006360 transcription by RNA polymerase I 1/255 55/18722 0.530160681714692 0.709731611153547 DDX11 1 GO:0006414 translational elongation 1/255 55/18722 0.530160681714692 0.709731611153547 ZNF598 1 GO:0010676 positive regulation of cellular carbohydrate metabolic process 1/255 55/18722 0.530160681714692 0.709731611153547 IRS1 1 GO:0031113 regulation of microtubule polymerization 1/255 55/18722 0.530160681714692 0.709731611153547 MET 1 GO:0045620 negative regulation of lymphocyte differentiation 1/255 55/18722 0.530160681714692 0.709731611153547 GLI3 1 GO:0048016 inositol phosphate-mediated signaling 1/255 55/18722 0.530160681714692 0.709731611153547 LMCD1 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/255 55/18722 0.530160681714692 0.709731611153547 BTC 1 GO:0140253 cell-cell fusion 1/255 55/18722 0.530160681714692 0.709731611153547 ADAM9 1 GO:1905517 macrophage migration 1/255 55/18722 0.530160681714692 0.709731611153547 PTK2 1 GO:0006282 regulation of DNA repair 2/255 130/18722 0.530765688085069 0.709731611153547 TWIST1/DDX11 2 GO:0006352 DNA-templated transcription, initiation 2/255 130/18722 0.530765688085069 0.709731611153547 TWIST1/MED23 2 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 2/255 130/18722 0.530765688085069 0.709731611153547 KDELR3/LMAN2L 2 GO:0030534 adult behavior 2/255 130/18722 0.530765688085069 0.709731611153547 NRXN3/SNCG 2 GO:0043467 regulation of generation of precursor metabolites and energy 2/255 130/18722 0.530765688085069 0.709731611153547 IRS1/P2RX7 2 GO:0021700 developmental maturation 4/255 280/18722 0.53169062816531 0.710664334053291 CATSPER2/DISC1/CLN5/PLD6 4 GO:0008016 regulation of heart contraction 3/255 206/18722 0.534291393856028 0.711114964735478 EHD3/GJA1/ISL1 3 GO:0007249 I-kappaB kinase/NF-kappaB signaling 4/255 281/18722 0.53450271220759 0.711114964735478 TLR3/GJA1/PDPK1/ZDHHC13 4 GO:0098813 nuclear chromosome segregation 4/255 281/18722 0.53450271220759 0.711114964735478 DDX11/KNTC1/KATNB1/SPICE1 4 GO:0045089 positive regulation of innate immune response 2/255 131/18722 0.534893072099947 0.711114964735478 PAK3/ZCCHC3 2 GO:2001233 regulation of apoptotic signaling pathway 5/255 356/18722 0.535104793872601 0.711114964735478 S100A8/CLU/SERPINE1/ITGAV/DNM1L 5 GO:0002886 regulation of myeloid leukocyte mediated immunity 1/255 56/18722 0.536578907790802 0.711114964735478 PDPK1 1 GO:0006687 glycosphingolipid metabolic process 1/255 56/18722 0.536578907790802 0.711114964735478 ITGB8 1 GO:0010518 positive regulation of phospholipase activity 1/255 56/18722 0.536578907790802 0.711114964735478 PDPK1 1 GO:0015800 acidic amino acid transport 1/255 56/18722 0.536578907790802 0.711114964735478 GJA1 1 GO:0031122 cytoplasmic microtubule organization 1/255 56/18722 0.536578907790802 0.711114964735478 DST 1 GO:0032608 interferon-beta production 1/255 56/18722 0.536578907790802 0.711114964735478 TLR3 1 GO:0032648 regulation of interferon-beta production 1/255 56/18722 0.536578907790802 0.711114964735478 TLR3 1 GO:0043470 regulation of carbohydrate catabolic process 1/255 56/18722 0.536578907790802 0.711114964735478 P2RX7 1 GO:0048008 platelet-derived growth factor receptor signaling pathway 1/255 56/18722 0.536578907790802 0.711114964735478 BCAR1 1 GO:0051653 spindle localization 1/255 56/18722 0.536578907790802 0.711114964735478 GJA1 1 GO:0051784 negative regulation of nuclear division 1/255 56/18722 0.536578907790802 0.711114964735478 KNTC1 1 GO:0071385 cellular response to glucocorticoid stimulus 1/255 56/18722 0.536578907790802 0.711114964735478 ISL1 1 GO:0098781 ncRNA transcription 1/255 56/18722 0.536578907790802 0.711114964735478 DDX11 1 GO:1904645 response to amyloid-beta 1/255 56/18722 0.536578907790802 0.711114964735478 GJA1 1 GO:1990089 response to nerve growth factor 1/255 56/18722 0.536578907790802 0.711114964735478 PDPK1 1 GO:0007569 cell aging 2/255 132/18722 0.538995604680433 0.714014948972595 TWIST1/SERPINE1 2 GO:0051146 striated muscle cell differentiation 4/255 283/18722 0.540101769922982 0.71517713178361 TNNT3/ISL1/SIX4/BHLHE41 4 GO:0051052 regulation of DNA metabolic process 5/255 359/18722 0.542570109750881 0.716769377150181 GJA1/PAK3/TWIST1/DDX11/BMPR2 5 GO:0006949 syncytium formation 1/255 57/18722 0.542909797028633 0.716769377150181 ADAM9 1 GO:0050879 multicellular organismal movement 1/255 57/18722 0.542909797028633 0.716769377150181 TNNT3 1 GO:0050881 musculoskeletal movement 1/255 57/18722 0.542909797028633 0.716769377150181 TNNT3 1 GO:0051205 protein insertion into membrane 1/255 57/18722 0.542909797028633 0.716769377150181 TIMM8A 1 GO:0051785 positive regulation of nuclear division 1/255 57/18722 0.542909797028633 0.716769377150181 BTC 1 GO:0061005 cell differentiation involved in kidney development 1/255 57/18722 0.542909797028633 0.716769377150181 GLI3 1 GO:1902905 positive regulation of supramolecular fiber organization 3/255 209/18722 0.544065388179298 0.717991696816008 MET/CLU/KATNB1 3 GO:0001508 action potential 2/255 134/18722 0.547125758531193 0.721356837510455 GJA1/CLDN19 2 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 2/255 134/18722 0.547125758531193 0.721356837510455 CLU/HSPBP1 2 GO:0001954 positive regulation of cell-matrix adhesion 1/255 58/18722 0.549154533259959 0.721356837510455 DISC1 1 GO:0002763 positive regulation of myeloid leukocyte differentiation 1/255 58/18722 0.549154533259959 0.721356837510455 CA2 1 GO:0006826 iron ion transport 1/255 58/18722 0.549154533259959 0.721356837510455 FLVCR2 1 GO:0010574 regulation of vascular endothelial growth factor production 1/255 58/18722 0.549154533259959 0.721356837510455 ISL1 1 GO:0018208 peptidyl-proline modification 1/255 58/18722 0.549154533259959 0.721356837510455 P3H2 1 GO:0032387 negative regulation of intracellular transport 1/255 58/18722 0.549154533259959 0.721356837510455 RAB23 1 GO:0043525 positive regulation of neuron apoptotic process 1/255 58/18722 0.549154533259959 0.721356837510455 PAK3 1 GO:0044380 protein localization to cytoskeleton 1/255 58/18722 0.549154533259959 0.721356837510455 DISC1 1 GO:0086065 cell communication involved in cardiac conduction 1/255 58/18722 0.549154533259959 0.721356837510455 GJA1 1 GO:0043491 protein kinase B signaling 3/255 211/18722 0.550515331484262 0.722840508776605 MET/LRP2/PTK2 3 GO:0140014 mitotic nuclear division 4/255 287/18722 0.55119714121292 0.723431779206373 BTC/KNTC1/KATNB1/SPICE1 4 GO:0009749 response to glucose 3/255 212/18722 0.553720197996481 0.72639478381716 EFNA5/GJA1/ATG7 3 GO:0097193 intrinsic apoptotic signaling pathway 4/255 288/18722 0.553949118516843 0.72639478381716 S100A8/TMEM117/CLU/DNM1L 4 GO:1900180 regulation of protein localization to nucleus 2/255 136/18722 0.5551555051103 0.72639478381716 GLI3/RAB23 2 GO:0035306 positive regulation of dephosphorylation 1/255 59/18722 0.555314284332543 0.72639478381716 SYMPK 1 GO:0046324 regulation of glucose import 1/255 59/18722 0.555314284332543 0.72639478381716 IRS1 1 GO:0051353 positive regulation of oxidoreductase activity 1/255 59/18722 0.555314284332543 0.72639478381716 SIRT3 1 GO:0051568 histone H3-K4 methylation 1/255 59/18722 0.555314284332543 0.72639478381716 ZNF335 1 GO:0071806 protein transmembrane transport 1/255 59/18722 0.555314284332543 0.72639478381716 ABCA1 1 GO:0000086 G2/M transition of mitotic cell cycle 2/255 137/18722 0.559132553761151 0.729940380405006 WEE1/PBX1 2 GO:0007586 digestion 2/255 137/18722 0.559132553761151 0.729940380405006 NR1H3/PBLD 2 GO:0010977 negative regulation of neuron projection development 2/255 137/18722 0.559132553761151 0.729940380405006 SEMA4G/KANK1 2 GO:0060048 cardiac muscle contraction 2/255 137/18722 0.559132553761151 0.729940380405006 EHD3/GJA1 2 GO:0034504 protein localization to nucleus 4/255 290/18722 0.559426307542396 0.729940380405006 TMCO6/GLI3/SIX4/RAB23 4 GO:0044403 biological process involved in symbiotic interaction 4/255 290/18722 0.559426307542396 0.729940380405006 ATG7/ITGAV/SP1/SLC52A1 4 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 1/255 60/18722 0.561390202325106 0.730056643469664 ZCCHC3 1 GO:0006081 cellular aldehyde metabolic process 1/255 60/18722 0.561390202325106 0.730056643469664 IDH1 1 GO:0009620 response to fungus 1/255 60/18722 0.561390202325106 0.730056643469664 S100A8 1 GO:0030071 regulation of mitotic metaphase/anaphase transition 1/255 60/18722 0.561390202325106 0.730056643469664 KNTC1 1 GO:0031638 zymogen activation 1/255 60/18722 0.561390202325106 0.730056643469664 SERPINE1 1 GO:0051851 modulation by host of symbiont process 1/255 60/18722 0.561390202325106 0.730056643469664 SP1 1 GO:0051965 positive regulation of synapse assembly 1/255 60/18722 0.561390202325106 0.730056643469664 CLSTN3 1 GO:0060038 cardiac muscle cell proliferation 1/255 60/18722 0.561390202325106 0.730056643469664 GJA1 1 GO:0009615 response to virus 5/255 367/18722 0.562200020235021 0.730056643469664 TLR3/CLU/ZCCHC3/ITGB8/ATG7 5 GO:0140694 non-membrane-bounded organelle assembly 5/255 367/18722 0.562200020235021 0.730056643469664 TNNT3/SIX4/KNTC1/SPICE1/GRB7 5 GO:0001539 cilium or flagellum-dependent cell motility 2/255 138/18722 0.563084307252199 0.730056643469664 CATSPER2/TTLL1 2 GO:0007224 smoothened signaling pathway 2/255 138/18722 0.563084307252199 0.730056643469664 GLI3/INTU 2 GO:0060285 cilium-dependent cell motility 2/255 138/18722 0.563084307252199 0.730056643469664 CATSPER2/TTLL1 2 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 2/255 138/18722 0.563084307252199 0.730056643469664 HSPBP1/PIAS3 2 GO:0007601 visual perception 3/255 215/18722 0.563253301569715 0.730056643469664 EYS/CLDN19/RP2 3 GO:0031669 cellular response to nutrient levels 3/255 215/18722 0.563253301569715 0.730056643469664 ATG7/BMPR2/DNM1L 3 GO:0016579 protein deubiquitination 2/255 139/18722 0.567010714344293 0.732977759093913 USP27X/USP19 2 GO:0030216 keratinocyte differentiation 2/255 139/18722 0.567010714344293 0.732977759093913 INTU/ADAM9 2 GO:0051783 regulation of nuclear division 2/255 139/18722 0.567010714344293 0.732977759093913 BTC/KNTC1 2 GO:0019748 secondary metabolic process 1/255 61/18722 0.567383423759416 0.732977759093913 N6AMT1 1 GO:0030199 collagen fibril organization 1/255 61/18722 0.567383423759416 0.732977759093913 COL14A1 1 GO:0043954 cellular component maintenance 1/255 61/18722 0.567383423759416 0.732977759093913 ITGA3 1 GO:0071384 cellular response to corticosteroid stimulus 1/255 61/18722 0.567383423759416 0.732977759093913 ISL1 1 GO:0090342 regulation of cell aging 1/255 61/18722 0.567383423759416 0.732977759093913 TWIST1 1 GO:0006979 response to oxidative stress 6/255 446/18722 0.569453222842619 0.735347653464125 MET/TXNRD2/IDH1/ATG7/SP1/ADAM9 6 GO:0030177 positive regulation of Wnt signaling pathway 2/255 140/18722 0.570911729857823 0.73605057237256 DISC1/KANK1 2 GO:0046165 alcohol biosynthetic process 2/255 140/18722 0.570911729857823 0.73605057237256 ASAH2B/SPR 2 GO:0045088 regulation of innate immune response 3/255 218/18722 0.572662417959046 0.73605057237256 NR1H3/PAK3/ZCCHC3 3 GO:0007062 sister chromatid cohesion 1/255 62/18722 0.573295069809539 0.73605057237256 DDX11 1 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 1/255 62/18722 0.573295069809539 0.73605057237256 KNTC1 1 GO:0010573 vascular endothelial growth factor production 1/255 62/18722 0.573295069809539 0.73605057237256 ISL1 1 GO:0031124 mRNA 3'-end processing 1/255 62/18722 0.573295069809539 0.73605057237256 SYMPK 1 GO:0032835 glomerulus development 1/255 62/18722 0.573295069809539 0.73605057237256 ENPEP 1 GO:0045428 regulation of nitric oxide biosynthetic process 1/255 62/18722 0.573295069809539 0.73605057237256 CLU 1 GO:0045576 mast cell activation 1/255 62/18722 0.573295069809539 0.73605057237256 PDPK1 1 GO:0046824 positive regulation of nucleocytoplasmic transport 1/255 62/18722 0.573295069809539 0.73605057237256 GLI3 1 GO:0048002 antigen processing and presentation of peptide antigen 1/255 62/18722 0.573295069809539 0.73605057237256 CTSF 1 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 1/255 62/18722 0.573295069809539 0.73605057237256 BMPR2 1 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 1/255 62/18722 0.573295069809539 0.73605057237256 CTNND1 1 GO:0034341 response to interferon-gamma 2/255 141/18722 0.574787314518405 0.737058004870749 TLR3/NR1H3 2 GO:0035296 regulation of tube diameter 2/255 141/18722 0.574787314518405 0.737058004870749 GJA1/BMPR2 2 GO:0097746 blood vessel diameter maintenance 2/255 141/18722 0.574787314518405 0.737058004870749 GJA1/BMPR2 2 GO:0009746 response to hexose 3/255 219/18722 0.575770876707685 0.737411471193244 EFNA5/GJA1/ATG7 3 GO:0050953 sensory perception of light stimulus 3/255 219/18722 0.575770876707685 0.737411471193244 EYS/CLDN19/RP2 3 GO:2001020 regulation of response to DNA damage stimulus 3/255 219/18722 0.575770876707685 0.737411471193244 CLU/TWIST1/DDX11 3 GO:0010038 response to metal ion 5/255 373/18722 0.576643319141543 0.738226289355724 SYT1/S100A8/SYT8/ADAM9/CA2 5 GO:0035150 regulation of tube size 2/255 142/18722 0.578637434805619 0.739587053673227 GJA1/BMPR2 2 GO:0001756 somitogenesis 1/255 63/18722 0.579126246508283 0.739587053673227 COBL 1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1/255 63/18722 0.579126246508283 0.739587053673227 TMEM117 1 GO:0099601 regulation of neurotransmitter receptor activity 1/255 63/18722 0.579126246508283 0.739587053673227 CNIH3 1 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 1/255 63/18722 0.579126246508283 0.739587053673227 KNTC1 1 GO:2000242 negative regulation of reproductive process 1/255 63/18722 0.579126246508283 0.739587053673227 GJA1 1 GO:0002253 activation of immune response 5/255 375/18722 0.581402242895042 0.742190363172797 PAK3/BCAR1/CLU/ZCCHC3/PTK2 5 GO:0006865 amino acid transport 2/255 143/18722 0.582462062804739 0.742551188240654 GJA1/SLC38A5 2 GO:0003012 muscle system process 6/255 452/18722 0.582541997337443 0.742551188240654 EHD3/GJA1/TNNT3/SSPN/LMCD1/PPP1R12B 6 GO:0001885 endothelial cell development 1/255 64/18722 0.584878044950879 0.742551188240654 MET 1 GO:0006749 glutathione metabolic process 1/255 64/18722 0.584878044950879 0.742551188240654 IDH1 1 GO:0030858 positive regulation of epithelial cell differentiation 1/255 64/18722 0.584878044950879 0.742551188240654 SERPINE1 1 GO:0045995 regulation of embryonic development 1/255 64/18722 0.584878044950879 0.742551188240654 LAMA5 1 GO:0046530 photoreceptor cell differentiation 1/255 64/18722 0.584878044950879 0.742551188240654 NAGLU 1 GO:0050771 negative regulation of axonogenesis 1/255 64/18722 0.584878044950879 0.742551188240654 SEMA4G 1 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 1/255 64/18722 0.584878044950879 0.742551188240654 EFNA5 1 GO:0080164 regulation of nitric oxide metabolic process 1/255 64/18722 0.584878044950879 0.742551188240654 CLU 1 GO:0098930 axonal transport 1/255 64/18722 0.584878044950879 0.742551188240654 DST 1 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 1/255 64/18722 0.584878044950879 0.742551188240654 USP19 1 GO:0000302 response to reactive oxygen species 3/255 222/18722 0.585011528143517 0.742551188240654 MET/TXNRD2/ADAM9 3 GO:0015931 nucleobase-containing compound transport 3/255 222/18722 0.585011528143517 0.742551188240654 GJA1/XPOT/SLC19A1 3 GO:0046718 viral entry into host cell 2/255 144/18722 0.586261176061413 0.743835231503011 ITGAV/SLC52A1 2 GO:0006913 nucleocytoplasmic transport 4/255 301/18722 0.588890192016977 0.744743166737197 TMCO6/GLI3/XPOT/RAB23 4 GO:0051169 nuclear transport 4/255 301/18722 0.588890192016977 0.744743166737197 TMCO6/GLI3/XPOT/RAB23 4 GO:0010965 regulation of mitotic sister chromatid separation 1/255 65/18722 0.590551541495928 0.744743166737197 KNTC1 1 GO:0015909 long-chain fatty acid transport 1/255 65/18722 0.590551541495928 0.744743166737197 ACSL1 1 GO:0035418 protein localization to synapse 1/255 65/18722 0.590551541495928 0.744743166737197 CLSTN3 1 GO:0038034 signal transduction in absence of ligand 1/255 65/18722 0.590551541495928 0.744743166737197 ITGAV 1 GO:0044784 metaphase/anaphase transition of cell cycle 1/255 65/18722 0.590551541495928 0.744743166737197 KNTC1 1 GO:0046513 ceramide biosynthetic process 1/255 65/18722 0.590551541495928 0.744743166737197 SIRT3 1 GO:0051310 metaphase plate congression 1/255 65/18722 0.590551541495928 0.744743166737197 SPICE1 1 GO:0060389 pathway-restricted SMAD protein phosphorylation 1/255 65/18722 0.590551541495928 0.744743166737197 BMPR2 1 GO:0070613 regulation of protein processing 1/255 65/18722 0.590551541495928 0.744743166737197 SERPINE1 1 GO:0071677 positive regulation of mononuclear cell migration 1/255 65/18722 0.590551541495928 0.744743166737197 SERPINE1 1 GO:0090307 mitotic spindle assembly 1/255 65/18722 0.590551541495928 0.744743166737197 SPICE1 1 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 1/255 65/18722 0.590551541495928 0.744743166737197 ITGAV 1 GO:1902475 L-alpha-amino acid transmembrane transport 1/255 65/18722 0.590551541495928 0.744743166737197 SLC38A5 1 GO:2001234 negative regulation of apoptotic signaling pathway 3/255 224/18722 0.591100715715228 0.745135028886683 CLU/SERPINE1/ITGAV 3 GO:0042542 response to hydrogen peroxide 2/255 146/18722 0.593782794980146 0.747912629710986 MET/ADAM9 2 GO:0045580 regulation of T cell differentiation 2/255 146/18722 0.593782794980146 0.747912629710986 GLI3/FANCA 2 GO:0034284 response to monosaccharide 3/255 225/18722 0.594123756439408 0.748040587781285 EFNA5/GJA1/ATG7 3 GO:0030099 myeloid cell differentiation 5/255 381/18722 0.595506926180515 0.748478050878444 TLR3/FBN1/ITGB8/PIAS3/CA2 5 GO:0014015 positive regulation of gliogenesis 1/255 66/18722 0.596147797963663 0.748478050878444 LRP2 1 GO:0030193 regulation of blood coagulation 1/255 66/18722 0.596147797963663 0.748478050878444 SERPINE1 1 GO:0050918 positive chemotaxis 1/255 66/18722 0.596147797963663 0.748478050878444 MET 1 GO:0050922 negative regulation of chemotaxis 1/255 66/18722 0.596147797963663 0.748478050878444 SEMA4G 1 GO:0071300 cellular response to retinoic acid 1/255 66/18722 0.596147797963663 0.748478050878444 ABCA1 1 GO:2000573 positive regulation of DNA biosynthetic process 1/255 66/18722 0.596147797963663 0.748478050878444 PAK3 1 GO:0051495 positive regulation of cytoskeleton organization 3/255 226/18722 0.5971323548651 0.749112247672998 MET/KATNB1/P2RX7 3 GO:0071241 cellular response to inorganic substance 3/255 226/18722 0.5971323548651 0.749112247672998 SYT1/DDX11/SYT8 3 GO:1902652 secondary alcohol metabolic process 2/255 147/18722 0.597505281767647 0.74927929595662 IDH1/ABCA1 2 GO:0098657 import into cell 3/255 227/18722 0.60012645893473 0.75057194618644 LRP2/SLC19A1/ACSL1 3 GO:0044839 cell cycle G2/M phase transition 2/255 148/18722 0.601202215792731 0.75057194618644 WEE1/PBX1 2 GO:0051384 response to glucocorticoid 2/255 148/18722 0.601202215792731 0.75057194618644 ISL1/ADAM9 2 GO:0006513 protein monoubiquitination 1/255 67/18722 0.601667861831548 0.75057194618644 ZNF598 1 GO:0009583 detection of light stimulus 1/255 67/18722 0.601667861831548 0.75057194618644 EYS 1 GO:0010517 regulation of phospholipase activity 1/255 67/18722 0.601667861831548 0.75057194618644 PDPK1 1 GO:0032890 regulation of organic acid transport 1/255 67/18722 0.601667861831548 0.75057194618644 ACSL1 1 GO:0035914 skeletal muscle cell differentiation 1/255 67/18722 0.601667861831548 0.75057194618644 SIX4 1 GO:0046635 positive regulation of alpha-beta T cell activation 1/255 67/18722 0.601667861831548 0.75057194618644 GLI3 1 GO:0051306 mitotic sister chromatid separation 1/255 67/18722 0.601667861831548 0.75057194618644 KNTC1 1 GO:0061077 chaperone-mediated protein folding 1/255 67/18722 0.601667861831548 0.75057194618644 CLU 1 GO:0072665 protein localization to vacuole 1/255 67/18722 0.601667861831548 0.75057194618644 CLU 1 GO:1903317 regulation of protein maturation 1/255 67/18722 0.601667861831548 0.75057194618644 SERPINE1 1 GO:0006650 glycerophospholipid metabolic process 4/255 306/18722 0.60189865508583 0.75057194618644 NR1H3/PLB1/PISD/PTDSS2 4 GO:0042692 muscle cell differentiation 5/255 384/18722 0.602460205655626 0.750972533974404 TNNT3/ISL1/SIX4/BHLHE41/BMPR2 5 GO:0009410 response to xenobiotic stimulus 6/255 462/18722 0.603902488791236 0.752470206328792 TLR3/ITGA3/N6AMT1/ACSL1/PTPRM/ABCA1 6 GO:0001666 response to hypoxia 4/255 307/18722 0.604470616292819 0.75286801392269 TWIST1/ADAM15/USP19/DNM1L 4 GO:0045786 negative regulation of cell cycle 5/255 385/18722 0.604763003032385 0.75286801392269 WEE1/SUSD2/KNTC1/GMNN/HEXIM2 5 GO:0071695 anatomical structure maturation 3/255 229/18722 0.606070988071028 0.75286801392269 CATSPER2/CLN5/PLD6 3 GO:0007585 respiratory gaseous exchange by respiratory system 1/255 68/18722 0.607112766427258 0.75286801392269 TTLL1 1 GO:0009247 glycolipid biosynthetic process 1/255 68/18722 0.607112766427258 0.75286801392269 GBGT1 1 GO:0031640 killing of cells of other organism 1/255 68/18722 0.607112766427258 0.75286801392269 P2RX7 1 GO:0032922 circadian regulation of gene expression 1/255 68/18722 0.607112766427258 0.75286801392269 BHLHE41 1 GO:0034394 protein localization to cell surface 1/255 68/18722 0.607112766427258 0.75286801392269 JAM3 1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 1/255 68/18722 0.607112766427258 0.75286801392269 ISL1 1 GO:0046637 regulation of alpha-beta T cell differentiation 1/255 68/18722 0.607112766427258 0.75286801392269 GLI3 1 GO:1900046 regulation of hemostasis 1/255 68/18722 0.607112766427258 0.75286801392269 SERPINE1 1 GO:1901016 regulation of potassium ion transmembrane transporter activity 1/255 68/18722 0.607112766427258 0.75286801392269 KCNG1 1 GO:0070665 positive regulation of leukocyte proliferation 2/255 150/18722 0.608519441271542 0.754313071786422 PTK2/ZNF335 2 GO:0030902 hindbrain development 2/255 151/18722 0.612139752075601 0.755331900058047 NAGLU/TTLL1 2 GO:0031497 chromatin assembly 2/255 151/18722 0.612139752075601 0.755331900058047 HIRA/CDAN1 2 GO:0043535 regulation of blood vessel endothelial cell migration 2/255 151/18722 0.612139752075601 0.755331900058047 SP1/PDPK1 2 GO:0044409 entry into host 2/255 151/18722 0.612139752075601 0.755331900058047 ITGAV/SLC52A1 2 GO:0071456 cellular response to hypoxia 2/255 151/18722 0.612139752075601 0.755331900058047 TWIST1/USP19 2 GO:1904064 positive regulation of cation transmembrane transport 2/255 151/18722 0.612139752075601 0.755331900058047 EHD3/PDPK1 2 GO:2001236 regulation of extrinsic apoptotic signaling pathway 2/255 151/18722 0.612139752075601 0.755331900058047 SERPINE1/ITGAV 2 GO:0010611 regulation of cardiac muscle hypertrophy 1/255 69/18722 0.612483531119069 0.755331900058047 LMCD1 1 GO:0015807 L-amino acid transport 1/255 69/18722 0.612483531119069 0.755331900058047 SLC38A5 1 GO:0031060 regulation of histone methylation 1/255 69/18722 0.612483531119069 0.755331900058047 ZNF335 1 GO:0050805 negative regulation of synaptic transmission 1/255 69/18722 0.612483531119069 0.755331900058047 PPP1R9A 1 GO:0050810 regulation of steroid biosynthetic process 1/255 69/18722 0.612483531119069 0.755331900058047 STARD4 1 GO:1901224 positive regulation of NIK/NF-kappaB signaling 1/255 69/18722 0.612483531119069 0.755331900058047 TLR3 1 GO:0016573 histone acetylation 2/255 152/18722 0.615734548568204 0.759041603264551 ISL1/TWIST1 2 GO:0002548 monocyte chemotaxis 1/255 70/18722 0.617781161503706 0.760964181986236 SERPINE1 1 GO:0045123 cellular extravasation 1/255 70/18722 0.617781161503706 0.760964181986236 JAM3 1 GO:0007338 single fertilization 2/255 153/18722 0.619303851359491 0.762539218084479 PLB1/KDM5B 2 GO:0045787 positive regulation of cell cycle 4/255 313/18722 0.619690426129415 0.762714683597645 BTC/PBX1/DDX11/USP19 4 GO:0046486 glycerolipid metabolic process 5/255 392/18722 0.620669084991257 0.763618460865227 NR1H3/PLB1/PISD/PTDSS2/ACSL1 5 GO:0046394 carboxylic acid biosynthetic process 4/255 314/18722 0.622191349758619 0.764087825735457 NR1H3/ASAH2B/STARD4/PRKAB1 4 GO:0016052 carbohydrate catabolic process 2/255 154/18722 0.622847685217617 0.764087825735457 MANBA/P2RX7 2 GO:0008344 adult locomotory behavior 1/255 71/18722 0.623006649591662 0.764087825735457 SNCG 1 GO:0033555 multicellular organismal response to stress 1/255 71/18722 0.623006649591662 0.764087825735457 GJA1 1 GO:0045824 negative regulation of innate immune response 1/255 71/18722 0.623006649591662 0.764087825735457 NR1H3 1 GO:0050795 regulation of behavior 1/255 71/18722 0.623006649591662 0.764087825735457 GJA1 1 GO:0050818 regulation of coagulation 1/255 71/18722 0.623006649591662 0.764087825735457 SERPINE1 1 GO:0061515 myeloid cell development 1/255 71/18722 0.623006649591662 0.764087825735457 FBN1 1 GO:0010970 transport along microtubule 2/255 155/18722 0.626366078952564 0.76414898747748 TMEM201/DST 2 GO:0046434 organophosphate catabolic process 2/255 155/18722 0.626366078952564 0.76414898747748 PDE10A/IDH1 2 GO:0051147 regulation of muscle cell differentiation 2/255 155/18722 0.626366078952564 0.76414898747748 BHLHE41/BMPR2 2 GO:0046395 carboxylic acid catabolic process 3/255 236/18722 0.626413753223112 0.76414898747748 ACADS/IRS1/TWIST1 3 GO:0048738 cardiac muscle tissue development 3/255 236/18722 0.626413753223112 0.76414898747748 GJA1/ISL1/LRP2 3 GO:0016053 organic acid biosynthetic process 4/255 316/18722 0.627162245711938 0.76414898747748 NR1H3/ASAH2B/STARD4/PRKAB1 4 GO:0001736 establishment of planar polarity 1/255 72/18722 0.628160973990039 0.76414898747748 INTU 1 GO:0005977 glycogen metabolic process 1/255 72/18722 0.628160973990039 0.76414898747748 IRS1 1 GO:0007164 establishment of tissue polarity 1/255 72/18722 0.628160973990039 0.76414898747748 INTU 1 GO:0014743 regulation of muscle hypertrophy 1/255 72/18722 0.628160973990039 0.76414898747748 LMCD1 1 GO:0030330 DNA damage response, signal transduction by p53 class mediator 1/255 72/18722 0.628160973990039 0.76414898747748 TWIST1 1 GO:0033045 regulation of sister chromatid segregation 1/255 72/18722 0.628160973990039 0.76414898747748 KNTC1 1 GO:0043903 regulation of biological process involved in symbiotic interaction 1/255 72/18722 0.628160973990039 0.76414898747748 ITGAV 1 GO:0051057 positive regulation of small GTPase mediated signal transduction 1/255 72/18722 0.628160973990039 0.76414898747748 ITGAV 1 GO:0055021 regulation of cardiac muscle tissue growth 1/255 72/18722 0.628160973990039 0.76414898747748 GJA1 1 GO:0070227 lymphocyte apoptotic process 1/255 72/18722 0.628160973990039 0.76414898747748 GLI3 1 GO:1901880 negative regulation of protein depolymerization 1/255 72/18722 0.628160973990039 0.76414898747748 KATNB1 1 GO:1905818 regulation of chromosome separation 1/255 72/18722 0.628160973990039 0.76414898747748 KNTC1 1 GO:0031334 positive regulation of protein-containing complex assembly 3/255 237/18722 0.629260575941039 0.76414898747748 MET/CLU/ABCA1 3 GO:1901617 organic hydroxy compound biosynthetic process 3/255 237/18722 0.629260575941039 0.76414898747748 ASAH2B/SPR/STARD4 3 GO:0010506 regulation of autophagy 4/255 317/18722 0.629632148605862 0.76414898747748 LZTS1/MET/ATG7/DNM1L 4 GO:0009267 cellular response to starvation 2/255 156/18722 0.629859065302309 0.76414898747748 ATG7/BMPR2 2 GO:0035051 cardiocyte differentiation 2/255 156/18722 0.629859065302309 0.76414898747748 ISL1/TWIST1 2 GO:0006073 cellular glucan metabolic process 1/255 73/18722 0.633245100082937 0.76414898747748 IRS1 1 GO:0009166 nucleotide catabolic process 1/255 73/18722 0.633245100082937 0.76414898747748 PDE10A 1 GO:0032456 endocytic recycling 1/255 73/18722 0.633245100082937 0.76414898747748 EHD3 1 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 1/255 73/18722 0.633245100082937 0.76414898747748 EFNA5 1 GO:0035924 cellular response to vascular endothelial growth factor stimulus 1/255 73/18722 0.633245100082937 0.76414898747748 NRP2 1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 1/255 73/18722 0.633245100082937 0.76414898747748 BTC 1 GO:0043299 leukocyte degranulation 1/255 73/18722 0.633245100082937 0.76414898747748 PDPK1 1 GO:0044042 glucan metabolic process 1/255 73/18722 0.633245100082937 0.76414898747748 IRS1 1 GO:0045739 positive regulation of DNA repair 1/255 73/18722 0.633245100082937 0.76414898747748 DDX11 1 GO:0050848 regulation of calcium-mediated signaling 1/255 73/18722 0.633245100082937 0.76414898747748 LMCD1 1 GO:0051298 centrosome duplication 1/255 73/18722 0.633245100082937 0.76414898747748 SPICE1 1 GO:0070988 demethylation 1/255 73/18722 0.633245100082937 0.76414898747748 KDM5B 1 GO:0086003 cardiac muscle cell contraction 1/255 73/18722 0.633245100082937 0.76414898747748 GJA1 1 GO:0099518 vesicle cytoskeletal trafficking 1/255 73/18722 0.633245100082937 0.76414898747748 MYO5B 1 GO:0002262 myeloid cell homeostasis 2/255 157/18722 0.633326680821335 0.76414898747748 CXCR2/JAM3 2 GO:0007034 vacuolar transport 2/255 157/18722 0.633326680821335 0.76414898747748 EHD3/CLU 2 GO:0070646 protein modification by small protein removal 2/255 157/18722 0.633326680821335 0.76414898747748 USP27X/USP19 2 GO:1902107 positive regulation of leukocyte differentiation 2/255 157/18722 0.633326680821335 0.76414898747748 GLI3/CA2 2 GO:1903708 positive regulation of hemopoiesis 2/255 157/18722 0.633326680821335 0.76414898747748 GLI3/CA2 2 GO:0018393 internal peptidyl-lysine acetylation 2/255 158/18722 0.636768965771426 0.767729960798479 ISL1/TWIST1 2 GO:0009895 negative regulation of catabolic process 4/255 320/18722 0.636979286884693 0.767729960798479 LZTS1/MET/ATG7/USP19 4 GO:0016054 organic acid catabolic process 3/255 240/18722 0.637711476273986 0.767729960798479 ACADS/IRS1/TWIST1 3 GO:0002437 inflammatory response to antigenic stimulus 1/255 74/18722 0.638259980209423 0.767729960798479 CXCR2 1 GO:0009201 ribonucleoside triphosphate biosynthetic process 1/255 74/18722 0.638259980209423 0.767729960798479 CTPS2 1 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 1/255 74/18722 0.638259980209423 0.767729960798479 ISL1 1 GO:0046323 glucose import 1/255 74/18722 0.638259980209423 0.767729960798479 IRS1 1 GO:1901568 fatty acid derivative metabolic process 1/255 74/18722 0.638259980209423 0.767729960798479 ACSL1 1 GO:0071824 protein-DNA complex subunit organization 3/255 241/18722 0.640498511513391 0.770126144085935 HIRA/KNTC1/GMNN 3 GO:0036293 response to decreased oxygen levels 4/255 322/18722 0.641824936796584 0.771158122733964 TWIST1/ADAM15/USP19/DNM1L 4 GO:0008088 axo-dendritic transport 1/255 75/18722 0.643206553839121 0.771158122733964 DST 1 GO:0033077 T cell differentiation in thymus 1/255 75/18722 0.643206553839121 0.771158122733964 GLI3 1 GO:0048662 negative regulation of smooth muscle cell proliferation 1/255 75/18722 0.643206553839121 0.771158122733964 BMPR2 1 GO:1903363 negative regulation of cellular protein catabolic process 1/255 75/18722 0.643206553839121 0.771158122733964 USP19 1 GO:2001259 positive regulation of cation channel activity 1/255 75/18722 0.643206553839121 0.771158122733964 EHD3 1 GO:0006475 internal protein amino acid acetylation 2/255 160/18722 0.643577722908857 0.771158122733964 ISL1/TWIST1 2 GO:0043271 negative regulation of ion transport 2/255 160/18722 0.643577722908857 0.771158122733964 GABRE/TWIST1 2 GO:0060402 calcium ion transport into cytosol 2/255 160/18722 0.643577722908857 0.771158122733964 P2RX7/PDPK1 2 GO:0043543 protein acylation 3/255 243/18722 0.646027569762454 0.773796916637665 ISL1/TWIST1/ZDHHC13 3 GO:0014823 response to activity 1/255 76/18722 0.648085747745434 0.77448105610114 COL4A2 1 GO:0014855 striated muscle cell proliferation 1/255 76/18722 0.648085747745434 0.77448105610114 GJA1 1 GO:0031100 animal organ regeneration 1/255 76/18722 0.648085747745434 0.77448105610114 GLI3 1 GO:0032720 negative regulation of tumor necrosis factor production 1/255 76/18722 0.648085747745434 0.77448105610114 TWIST1 1 GO:0071426 ribonucleoprotein complex export from nucleus 1/255 76/18722 0.648085747745434 0.77448105610114 XPOT 1 GO:0086001 cardiac muscle cell action potential 1/255 76/18722 0.648085747745434 0.77448105610114 GJA1 1 GO:0006814 sodium ion transport 3/255 245/18722 0.651496510109068 0.778259401410871 SLC13A4/P2RX7/PRSS8 3 GO:0006367 transcription initiation from RNA polymerase II promoter 1/255 77/18722 0.65289847617646 0.778446294563693 MED23 1 GO:0010827 regulation of glucose transmembrane transport 1/255 77/18722 0.65289847617646 0.778446294563693 IRS1 1 GO:0032418 lysosome localization 1/255 77/18722 0.65289847617646 0.778446294563693 PDPK1 1 GO:0055117 regulation of cardiac muscle contraction 1/255 77/18722 0.65289847617646 0.778446294563693 EHD3 1 GO:0071166 ribonucleoprotein complex localization 1/255 77/18722 0.65289847617646 0.778446294563693 XPOT 1 GO:0061025 membrane fusion 2/255 163/18722 0.653602087367935 0.77898799505141 SYT1/DNM1L 2 GO:0048285 organelle fission 6/255 488/18722 0.656557352215289 0.781768403896118 BTC/FANCA/KNTC1/KATNB1/SPICE1/DNM1L 6 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 1/255 78/18722 0.657645641023604 0.781768403896118 S100A8 1 GO:0009064 glutamine family amino acid metabolic process 1/255 78/18722 0.657645641023604 0.781768403896118 CTPS2 1 GO:0070373 negative regulation of ERK1 and ERK2 cascade 1/255 78/18722 0.657645641023604 0.781768403896118 SIRT3 1 GO:0090559 regulation of membrane permeability 1/255 78/18722 0.657645641023604 0.781768403896118 JAM3 1 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 1/255 78/18722 0.657645641023604 0.781768403896118 TWIST1 1 GO:0006325 chromatin organization 5/255 409/18722 0.657686122829726 0.781768403896118 HIRA/SS18L1/CDAN1/KDM5B/DDX11 5 GO:0021537 telencephalon development 3/255 248/18722 0.659586998950761 0.783729799133509 TACC2/GLI3/DISC1 3 GO:0010498 proteasomal protein catabolic process 6/255 490/18722 0.660425366588414 0.784427696917064 CLU/KLHL42/RMND5B/HSPBP1/USP19/ZNF598 6 GO:1901988 negative regulation of cell cycle phase transition 3/255 249/18722 0.66225368492121 0.784897767334963 WEE1/SUSD2/KNTC1 3 GO:0001895 retina homeostasis 1/255 79/18722 0.662328131987935 0.784897767334963 POTEI 1 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 1/255 79/18722 0.662328131987935 0.784897767334963 PTK2 1 GO:0051279 regulation of release of sequestered calcium ion into cytosol 1/255 79/18722 0.662328131987935 0.784897767334963 PDPK1 1 GO:0060420 regulation of heart growth 1/255 79/18722 0.662328131987935 0.784897767334963 GJA1 1 GO:1901184 regulation of ERBB signaling pathway 1/255 79/18722 0.662328131987935 0.784897767334963 BTC 1 GO:0009451 RNA modification 2/255 167/18722 0.666617999086752 0.788875410134733 TYW1/TRMT61B 2 GO:0031960 response to corticosteroid 2/255 167/18722 0.666617999086752 0.788875410134733 ISL1/ADAM9 2 GO:0055088 lipid homeostasis 2/255 167/18722 0.666617999086752 0.788875410134733 NR1H3/ABCA1 2 GO:0021766 hippocampus development 1/255 80/18722 0.666946826744309 0.788875410134733 GLI3 1 GO:0048145 regulation of fibroblast proliferation 1/255 80/18722 0.666946826744309 0.788875410134733 BTC 1 GO:0000070 mitotic sister chromatid segregation 2/255 168/18722 0.669809934646333 0.790970824424347 KNTC1/KATNB1 2 GO:0002833 positive regulation of response to biotic stimulus 2/255 168/18722 0.669809934646333 0.790970824424347 PAK3/ZCCHC3 2 GO:1902806 regulation of cell cycle G1/S phase transition 2/255 168/18722 0.669809934646333 0.790970824424347 WEE1/SUSD2 2 GO:2000241 regulation of reproductive process 2/255 168/18722 0.669809934646333 0.790970824424347 GJA1/PLB1 2 GO:0061448 connective tissue development 3/255 252/18722 0.670163258323497 0.790970824424347 GLI3/ITGB8/BMPR2 3 GO:0001960 negative regulation of cytokine-mediated signaling pathway 1/255 81/18722 0.671502591103294 0.790970824424347 NR1H3 1 GO:0006096 glycolytic process 1/255 81/18722 0.671502591103294 0.790970824424347 P2RX7 1 GO:0048144 fibroblast proliferation 1/255 81/18722 0.671502591103294 0.790970824424347 BTC 1 GO:0048708 astrocyte differentiation 1/255 81/18722 0.671502591103294 0.790970824424347 S100A8 1 GO:2000106 regulation of leukocyte apoptotic process 1/255 81/18722 0.671502591103294 0.790970824424347 CXCR2 1 GO:2000243 positive regulation of reproductive process 1/255 81/18722 0.671502591103294 0.790970824424347 PLB1 1 GO:0008654 phospholipid biosynthetic process 3/255 253/18722 0.672769619900901 0.79121660804027 PISD/IDH1/PTDSS2 3 GO:0009743 response to carbohydrate 3/255 253/18722 0.672769619900901 0.79121660804027 EFNA5/GJA1/ATG7 3 GO:0097305 response to alcohol 3/255 253/18722 0.672769619900901 0.79121660804027 S100A8/ADAM15/ABCA1 3 GO:0009152 purine ribonucleotide biosynthetic process 2/255 169/18722 0.672977198134732 0.79121660804027 SLC26A2/ACSL1 2 GO:0018394 peptidyl-lysine acetylation 2/255 169/18722 0.672977198134732 0.79121660804027 ISL1/TWIST1 2 GO:0006839 mitochondrial transport 3/255 254/18722 0.675360903471036 0.79178724603041 TIMM8A/PSEN2/TOMM34 3 GO:0009165 nucleotide biosynthetic process 3/255 254/18722 0.675360903471036 0.79178724603041 CTPS2/SLC26A2/ACSL1 3 GO:0006757 ATP generation from ADP 1/255 82/18722 0.675996279170922 0.79178724603041 P2RX7 1 GO:0008543 fibroblast growth factor receptor signaling pathway 1/255 82/18722 0.675996279170922 0.79178724603041 GALNT3 1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 1/255 82/18722 0.675996279170922 0.79178724603041 SERPINE1 1 GO:0009205 purine ribonucleoside triphosphate metabolic process 1/255 82/18722 0.675996279170922 0.79178724603041 RAB23 1 GO:0016575 histone deacetylation 1/255 82/18722 0.675996279170922 0.79178724603041 SIRT3 1 GO:0035082 axoneme assembly 1/255 82/18722 0.675996279170922 0.79178724603041 TTLL1 1 GO:0043242 negative regulation of protein-containing complex disassembly 1/255 82/18722 0.675996279170922 0.79178724603041 KATNB1 1 GO:2001252 positive regulation of chromosome organization 1/255 82/18722 0.675996279170922 0.79178724603041 DDX11 1 GO:0043547 positive regulation of GTPase activity 3/255 255/18722 0.677937113514415 0.793763012263974 EVI5/ARHGAP24/CHN2 3 GO:0001510 RNA methylation 1/255 83/18722 0.680428733506299 0.795271896133347 TRMT61B 1 GO:0046785 microtubule polymerization 1/255 83/18722 0.680428733506299 0.795271896133347 MET 1 GO:0051899 membrane depolarization 1/255 83/18722 0.680428733506299 0.795271896133347 P2RX7 1 GO:1901292 nucleoside phosphate catabolic process 1/255 83/18722 0.680428733506299 0.795271896133347 PDE10A 1 GO:1901293 nucleoside phosphate biosynthetic process 3/255 256/18722 0.680498256083382 0.795271896133347 CTPS2/SLC26A2/ACSL1 3 GO:0002088 lens development in camera-type eye 1/255 84/18722 0.684800785277096 0.798210538601613 KDM5B 1 GO:0006112 energy reserve metabolic process 1/255 84/18722 0.684800785277096 0.798210538601613 IRS1 1 GO:0006405 RNA export from nucleus 1/255 84/18722 0.684800785277096 0.798210538601613 XPOT 1 GO:0032508 DNA duplex unwinding 1/255 84/18722 0.684800785277096 0.798210538601613 DDX11 1 GO:0045445 myoblast differentiation 1/255 84/18722 0.684800785277096 0.798210538601613 ISL1 1 GO:1900542 regulation of purine nucleotide metabolic process 1/255 84/18722 0.684800785277096 0.798210538601613 P2RX7 1 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 1/255 84/18722 0.684800785277096 0.798210538601613 WEE1 1 GO:0045165 cell fate commitment 3/255 258/18722 0.685575370697197 0.79881544870572 TEAD3/GLI3/ISL1 3 GO:0001933 negative regulation of protein phosphorylation 4/255 342/18722 0.687932847582166 0.799955022303313 PLPP3/TWIST1/PDPK1/HEXIM2 4 GO:0007584 response to nutrient 2/255 174/18722 0.688446214883773 0.799955022303313 ACSL1/ABCA1 2 GO:0045619 regulation of lymphocyte differentiation 2/255 174/18722 0.688446214883773 0.799955022303313 GLI3/FANCA 2 GO:0009142 nucleoside triphosphate biosynthetic process 1/255 85/18722 0.689113254412966 0.799955022303313 CTPS2 1 GO:0030433 ubiquitin-dependent ERAD pathway 1/255 85/18722 0.689113254412966 0.799955022303313 USP19 1 GO:0032092 positive regulation of protein binding 1/255 85/18722 0.689113254412966 0.799955022303313 PLXND1 1 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 1/255 85/18722 0.689113254412966 0.799955022303313 ISL1 1 GO:0055013 cardiac muscle cell development 1/255 85/18722 0.689113254412966 0.799955022303313 ISL1 1 GO:0072384 organelle transport along microtubule 1/255 85/18722 0.689113254412966 0.799955022303313 TMEM201 1 GO:0097006 regulation of plasma lipoprotein particle levels 1/255 85/18722 0.689113254412966 0.799955022303313 ABCA1 1 GO:0052126 movement in host environment 2/255 175/18722 0.691467147071092 0.802091623829681 ITGAV/SLC52A1 2 GO:1905475 regulation of protein localization to membrane 2/255 175/18722 0.691467147071092 0.802091623829681 ITGA3/PDPK1 2 GO:0006140 regulation of nucleotide metabolic process 1/255 86/18722 0.693366949756889 0.80310293476289 P2RX7 1 GO:0015908 fatty acid transport 1/255 86/18722 0.693366949756889 0.80310293476289 ACSL1 1 GO:0060761 negative regulation of response to cytokine stimulus 1/255 86/18722 0.693366949756889 0.80310293476289 NR1H3 1 GO:2001251 negative regulation of chromosome organization 1/255 86/18722 0.693366949756889 0.80310293476289 KNTC1 1 GO:0043534 blood vessel endothelial cell migration 2/255 176/18722 0.694463995509911 0.803777772580916 SP1/PDPK1 2 GO:0050728 negative regulation of inflammatory response 2/255 176/18722 0.694463995509911 0.803777772580916 NR1H3/ISL1 2 GO:0007059 chromosome segregation 4/255 346/18722 0.696635973006544 0.805871845210834 DDX11/KNTC1/KATNB1/SPICE1 4 GO:0006333 chromatin assembly or disassembly 2/255 177/18722 0.697436852909881 0.805871845210834 HIRA/CDAN1 2 GO:0007029 endoplasmic reticulum organization 1/255 87/18722 0.697562669214498 0.805871845210834 LMAN2L 1 GO:1900182 positive regulation of protein localization to nucleus 1/255 87/18722 0.697562669214498 0.805871845210834 GLI3 1 GO:1901879 regulation of protein depolymerization 1/255 87/18722 0.697562669214498 0.805871845210834 KATNB1 1 GO:0006109 regulation of carbohydrate metabolic process 2/255 178/18722 0.700385813925521 0.808262532138538 IRS1/P2RX7 2 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 3/255 264/18722 0.700446190395536 0.808262532138538 EFNA5/BTC/ISL1 3 GO:0007260 tyrosine phosphorylation of STAT protein 1/255 88/18722 0.701701199901393 0.808262532138538 ISL1 1 GO:0009144 purine nucleoside triphosphate metabolic process 1/255 88/18722 0.701701199901393 0.808262532138538 RAB23 1 GO:0030101 natural killer cell activation 1/255 88/18722 0.701701199901393 0.808262532138538 PBX1 1 GO:0050829 defense response to Gram-negative bacterium 1/255 88/18722 0.701701199901393 0.808262532138538 SERPINE1 1 GO:0070098 chemokine-mediated signaling pathway 1/255 88/18722 0.701701199901393 0.808262532138538 CXCR2 1 GO:1901657 glycosyl compound metabolic process 1/255 88/18722 0.701701199901393 0.808262532138538 TYW1 1 GO:0051607 defense response to virus 3/255 265/18722 0.702872243619263 0.808924106420816 TLR3/ZCCHC3/ATG7 3 GO:0140546 defense response to symbiont 3/255 265/18722 0.702872243619263 0.808924106420816 TLR3/ZCCHC3/ATG7 3 GO:0007626 locomotory behavior 2/255 179/18722 0.703310975086515 0.808924106420816 SNCG/NAGLU 2 GO:1901991 negative regulation of mitotic cell cycle phase transition 2/255 179/18722 0.703310975086515 0.808924106420816 WEE1/KNTC1 2 GO:0014910 regulation of smooth muscle cell migration 1/255 89/18722 0.705783318288489 0.811067202693793 SERPINE1 1 GO:0046330 positive regulation of JNK cascade 1/255 89/18722 0.705783318288489 0.811067202693793 TLR3 1 GO:0043409 negative regulation of MAPK cascade 2/255 180/18722 0.70621243472954 0.811067202693793 SIRT3/P2RX7 2 GO:0048660 regulation of smooth muscle cell proliferation 2/255 180/18722 0.70621243472954 0.811067202693793 GJA1/BMPR2 2 GO:0045861 negative regulation of proteolysis 4/255 351/18722 0.70727039521271 0.811619317537277 NR1H3/CRIM1/SERPINE1/USP19 4 GO:0032412 regulation of ion transmembrane transporter activity 3/255 267/18722 0.707679591840713 0.811619317537277 EHD3/CNIH3/KCNG1 3 GO:0002683 negative regulation of immune system process 5/255 434/18722 0.707773896877597 0.811619317537277 TLR3/FBN1/NR1H3/GLI3/PIAS3 5 GO:0030901 midbrain development 1/255 90/18722 0.709809790345401 0.811619317537277 CXCR2 1 GO:0032392 DNA geometric change 1/255 90/18722 0.709809790345401 0.811619317537277 DDX11 1 GO:0034109 homotypic cell-cell adhesion 1/255 90/18722 0.709809790345401 0.811619317537277 PLPP3 1 GO:0035304 regulation of protein dephosphorylation 1/255 90/18722 0.709809790345401 0.811619317537277 SYMPK 1 GO:0046031 ADP metabolic process 1/255 90/18722 0.709809790345401 0.811619317537277 P2RX7 1 GO:0048477 oogenesis 1/255 90/18722 0.709809790345401 0.811619317537277 PLD6 1 GO:0061097 regulation of protein tyrosine kinase activity 1/255 90/18722 0.709809790345401 0.811619317537277 BTC 1 GO:0097581 lamellipodium organization 1/255 90/18722 0.709809790345401 0.811619317537277 KANK1 1 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 1/255 90/18722 0.709809790345401 0.811619317537277 GJA1 1 GO:0002275 myeloid cell activation involved in immune response 1/255 91/18722 0.713781371681914 0.81437268583643 PDPK1 1 GO:0019935 cyclic-nucleotide-mediated signaling 1/255 91/18722 0.713781371681914 0.81437268583643 PDE10A 1 GO:0045582 positive regulation of T cell differentiation 1/255 91/18722 0.713781371681914 0.81437268583643 GLI3 1 GO:0051983 regulation of chromosome segregation 1/255 91/18722 0.713781371681914 0.81437268583643 KNTC1 1 GO:0055006 cardiac cell development 1/255 91/18722 0.713781371681914 0.81437268583643 ISL1 1 GO:1990874 vascular associated smooth muscle cell proliferation 1/255 91/18722 0.713781371681914 0.81437268583643 GJA1 1 GO:0000280 nuclear division 5/255 439/18722 0.717154149824637 0.817052376693484 BTC/FANCA/KNTC1/KATNB1/SPICE1 5 GO:0007051 spindle organization 2/255 184/18722 0.717583284406983 0.817052376693484 TACC2/SPICE1 2 GO:0048659 smooth muscle cell proliferation 2/255 184/18722 0.717583284406983 0.817052376693484 GJA1/BMPR2 2 GO:0031058 positive regulation of histone modification 1/255 92/18722 0.717698807687556 0.817052376693484 ISL1 1 GO:0034502 protein localization to chromosome 1/255 92/18722 0.717698807687556 0.817052376693484 KNTC1 1 GO:0070509 calcium ion import 1/255 92/18722 0.717698807687556 0.817052376693484 PSEN2 1 GO:0043433 negative regulation of DNA-binding transcription factor activity 2/255 185/18722 0.72036777016886 0.819659707457843 TWIST1/SETD6 2 GO:0032088 negative regulation of NF-kappaB transcription factor activity 1/255 93/18722 0.721562833669289 0.819659707457843 SETD6 1 GO:0090398 cellular senescence 1/255 93/18722 0.721562833669289 0.819659707457843 TWIST1 1 GO:1901019 regulation of calcium ion transmembrane transporter activity 1/255 93/18722 0.721562833669289 0.819659707457843 EHD3 1 GO:1901796 regulation of signal transduction by p53 class mediator 1/255 93/18722 0.721562833669289 0.819659707457843 TWIST1 1 GO:1901992 positive regulation of mitotic cell cycle phase transition 1/255 93/18722 0.721562833669289 0.819659707457843 PBX1 1 GO:0071900 regulation of protein serine/threonine kinase activity 4/255 359/18722 0.723720951945471 0.821812490853777 BMPR2/ACSL1/ADAM9/HEXIM2 4 GO:0022411 cellular component disassembly 5/255 443/18722 0.724504311413683 0.822158865689311 DDR1/ADAM15/ATG7/KATNB1/DNM1L 5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 1/255 94/18722 0.725374174987359 0.822158865689311 HEXIM2 1 GO:0010389 regulation of G2/M transition of mitotic cell cycle 1/255 94/18722 0.725374174987359 0.822158865689311 PBX1 1 GO:0019080 viral gene expression 1/255 94/18722 0.725374174987359 0.822158865689311 SP1 1 GO:0051702 biological process involved in interaction with symbiont 1/255 94/18722 0.725374174987359 0.822158865689311 SP1 1 GO:0002695 negative regulation of leukocyte activation 2/255 187/18722 0.725867619339779 0.822158865689311 NR1H3/GLI3 2 GO:0033044 regulation of chromosome organization 2/255 187/18722 0.725867619339779 0.822158865689311 DDX11/KNTC1 2 GO:1903829 positive regulation of cellular protein localization 3/255 276/18722 0.728579011584082 0.824065943930069 GLI3/ITGA3/PDPK1 3 GO:0002532 production of molecular mediator involved in inflammatory response 1/255 95/18722 0.729133547189325 0.824065943930069 SERPINE1 1 GO:0008593 regulation of Notch signaling pathway 1/255 95/18722 0.729133547189325 0.824065943930069 EPN2 1 GO:0050764 regulation of phagocytosis 1/255 95/18722 0.729133547189325 0.824065943930069 ITGAV 1 GO:1901379 regulation of potassium ion transmembrane transport 1/255 95/18722 0.729133547189325 0.824065943930069 KCNG1 1 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 1/255 95/18722 0.729133547189325 0.824065943930069 PIAS3 1 GO:0009060 aerobic respiration 2/255 189/18722 0.731276039876466 0.825867355010685 IDH1/SIRT3 2 GO:0002718 regulation of cytokine production involved in immune response 1/255 96/18722 0.732841656142281 0.825867355010685 TLR3 1 GO:0006637 acyl-CoA metabolic process 1/255 96/18722 0.732841656142281 0.825867355010685 ACSL1 1 GO:0035383 thioester metabolic process 1/255 96/18722 0.732841656142281 0.825867355010685 ACSL1 1 GO:0042472 inner ear morphogenesis 1/255 96/18722 0.732841656142281 0.825867355010685 SIX4 1 GO:0051304 chromosome separation 1/255 96/18722 0.732841656142281 0.825867355010685 KNTC1 1 GO:0055017 cardiac muscle tissue growth 1/255 96/18722 0.732841656142281 0.825867355010685 GJA1 1 GO:1901655 cellular response to ketone 1/255 96/18722 0.732841656142281 0.825867355010685 ADAM15 1 GO:0022407 regulation of cell-cell adhesion 5/255 448/18722 0.733499496179472 0.826310715775361 EFNA5/GLI3/PLPP3/TENM3/PTK2 5 GO:0009755 hormone-mediated signaling pathway 2/255 190/18722 0.733946244562406 0.826516041173881 ISL1/ACSL1 2 GO:0010596 negative regulation of endothelial cell migration 1/255 97/18722 0.736499198163312 0.827708030654637 PTPRM 1 GO:0035335 peptidyl-tyrosine dephosphorylation 1/255 97/18722 0.736499198163312 0.827708030654637 PTPRM 1 GO:0043255 regulation of carbohydrate biosynthetic process 1/255 97/18722 0.736499198163312 0.827708030654637 IRS1 1 GO:1990868 response to chemokine 1/255 97/18722 0.736499198163312 0.827708030654637 CXCR2 1 GO:1990869 cellular response to chemokine 1/255 97/18722 0.736499198163312 0.827708030654637 CXCR2 1 GO:0006164 purine nucleotide biosynthetic process 2/255 191/18722 0.736593930640174 0.827708030654637 SLC26A2/ACSL1 2 GO:0001701 in utero embryonic development 4/255 367/18722 0.739479753087651 0.829269967000034 GLI3/TTLL1/TWIST1/ZNF335 4 GO:0002367 cytokine production involved in immune response 1/255 98/18722 0.74010686014819 0.829269967000034 TLR3 1 GO:0003333 amino acid transmembrane transport 1/255 98/18722 0.74010686014819 0.829269967000034 SLC38A5 1 GO:0043473 pigmentation 1/255 98/18722 0.74010686014819 0.829269967000034 GLI3 1 GO:0043502 regulation of muscle adaptation 1/255 98/18722 0.74010686014819 0.829269967000034 LMCD1 1 GO:0070301 cellular response to hydrogen peroxide 1/255 98/18722 0.74010686014819 0.829269967000034 MET 1 GO:1904029 regulation of cyclin-dependent protein kinase activity 1/255 98/18722 0.74010686014819 0.829269967000034 HEXIM2 1 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 1/255 98/18722 0.74010686014819 0.829269967000034 CLU 1 GO:0002444 myeloid leukocyte mediated immunity 1/255 99/18722 0.743665319698352 0.831171002881742 PDPK1 1 GO:0003300 cardiac muscle hypertrophy 1/255 99/18722 0.743665319698352 0.831171002881742 LMCD1 1 GO:0006165 nucleoside diphosphate phosphorylation 1/255 99/18722 0.743665319698352 0.831171002881742 P2RX7 1 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 1/255 99/18722 0.743665319698352 0.831171002881742 CLU 1 GO:0031341 regulation of cell killing 1/255 99/18722 0.743665319698352 0.831171002881742 P2RX7 1 GO:0033209 tumor necrosis factor-mediated signaling pathway 1/255 99/18722 0.743665319698352 0.831171002881742 PIAS3 1 GO:0051153 regulation of striated muscle cell differentiation 1/255 99/18722 0.743665319698352 0.831171002881742 BHLHE41 1 GO:0044262 cellular carbohydrate metabolic process 3/255 283/18722 0.744014186417928 0.831263615500902 B3GNT3/IRS1/IDH1 3 GO:1901654 response to ketone 2/255 194/18722 0.744403034615726 0.831400816002196 NR1H3/ADAM15 2 GO:0019218 regulation of steroid metabolic process 1/255 100/18722 0.747175245246165 0.834198871523496 STARD4 1 GO:0022408 negative regulation of cell-cell adhesion 2/255 196/18722 0.749498650241622 0.836494029287525 GLI3/PTK2 2 GO:0006476 protein deacetylation 1/255 101/18722 0.750637296178515 0.836868194990318 SIRT3 1 GO:0046939 nucleotide phosphorylation 1/255 101/18722 0.750637296178515 0.836868194990318 P2RX7 1 GO:0098869 cellular oxidant detoxification 1/255 101/18722 0.750637296178515 0.836868194990318 TXNRD2 1 GO:0042594 response to starvation 2/255 197/18722 0.752013679240147 0.837804901114246 ATG7/BMPR2 2 GO:0071248 cellular response to metal ion 2/255 197/18722 0.752013679240147 0.837804901114246 SYT1/SYT8 2 GO:0014897 striated muscle hypertrophy 1/255 102/18722 0.754052122958735 0.838581097596458 LMCD1 1 GO:0034308 primary alcohol metabolic process 1/255 102/18722 0.754052122958735 0.838581097596458 PLB1 1 GO:1902749 regulation of cell cycle G2/M phase transition 1/255 102/18722 0.754052122958735 0.838581097596458 PBX1 1 GO:1904063 negative regulation of cation transmembrane transport 1/255 102/18722 0.754052122958735 0.838581097596458 TWIST1 1 GO:1990542 mitochondrial transmembrane transport 1/255 102/18722 0.754052122958735 0.838581097596458 PSEN2 1 GO:0006323 DNA packaging 2/255 199/18722 0.756978783475453 0.840233811731113 HIRA/CDAN1 2 GO:0002027 regulation of heart rate 1/255 103/18722 0.757420367246894 0.840233811731113 ISL1 1 GO:0009135 purine nucleoside diphosphate metabolic process 1/255 103/18722 0.757420367246894 0.840233811731113 P2RX7 1 GO:0009179 purine ribonucleoside diphosphate metabolic process 1/255 103/18722 0.757420367246894 0.840233811731113 P2RX7 1 GO:0014013 regulation of gliogenesis 1/255 103/18722 0.757420367246894 0.840233811731113 LRP2 1 GO:0019233 sensory perception of pain 1/255 103/18722 0.757420367246894 0.840233811731113 P2RX7 1 GO:0045639 positive regulation of myeloid cell differentiation 1/255 103/18722 0.757420367246894 0.840233811731113 CA2 1 GO:0071103 DNA conformation change 3/255 290/18722 0.75874553644319 0.84099021963461 HIRA/CDAN1/DDX11 3 GO:0072522 purine-containing compound biosynthetic process 2/255 200/18722 0.759429102532783 0.84099021963461 SLC26A2/ACSL1 2 GO:0014896 muscle hypertrophy 1/255 104/18722 0.760742662018474 0.84099021963461 LMCD1 1 GO:0045621 positive regulation of lymphocyte differentiation 1/255 104/18722 0.760742662018474 0.84099021963461 GLI3 1 GO:0046634 regulation of alpha-beta T cell activation 1/255 104/18722 0.760742662018474 0.84099021963461 GLI3 1 GO:0048661 positive regulation of smooth muscle cell proliferation 1/255 104/18722 0.760742662018474 0.84099021963461 GJA1 1 GO:0060419 heart growth 1/255 104/18722 0.760742662018474 0.84099021963461 GJA1 1 GO:0002429 immune response-activating cell surface receptor signaling pathway 3/255 291/18722 0.760793392290254 0.84099021963461 PAK3/BCAR1/PTK2 3 GO:0002757 immune response-activating signal transduction 3/255 291/18722 0.760793392290254 0.84099021963461 PAK3/BCAR1/PTK2 3 GO:0016236 macroautophagy 3/255 291/18722 0.760793392290254 0.84099021963461 LZTS1/ATG7/RAB23 3 GO:0006473 protein acetylation 2/255 201/18722 0.761858096593811 0.841571775134556 ISL1/TWIST1 2 GO:0051054 positive regulation of DNA metabolic process 2/255 201/18722 0.761858096593811 0.841571775134556 PAK3/DDX11 2 GO:0000041 transition metal ion transport 1/255 105/18722 0.76401963168145 0.843363245851124 FLVCR2 1 GO:2001022 positive regulation of response to DNA damage stimulus 1/255 105/18722 0.76401963168145 0.843363245851124 DDX11 1 GO:0010948 negative regulation of cell cycle process 3/255 294/18722 0.766853019139227 0.844544615392527 WEE1/SUSD2/KNTC1 3 GO:0001824 blastocyst development 1/255 106/18722 0.767251892191803 0.844544615392527 TTLL1 1 GO:0006090 pyruvate metabolic process 1/255 106/18722 0.767251892191803 0.844544615392527 P2RX7 1 GO:0006906 vesicle fusion 1/255 106/18722 0.767251892191803 0.844544615392527 SYT1 1 GO:0009185 ribonucleoside diphosphate metabolic process 1/255 106/18722 0.767251892191803 0.844544615392527 P2RX7 1 GO:0019882 antigen processing and presentation 1/255 106/18722 0.767251892191803 0.844544615392527 CTSF 1 GO:0046620 regulation of organ growth 1/255 106/18722 0.767251892191803 0.844544615392527 GJA1 1 GO:0090263 positive regulation of canonical Wnt signaling pathway 1/255 106/18722 0.767251892191803 0.844544615392527 KANK1 1 GO:0036503 ERAD pathway 1/255 107/18722 0.770440051167474 0.847456937662216 USP19 1 GO:0051341 regulation of oxidoreductase activity 1/255 107/18722 0.770440051167474 0.847456937662216 SIRT3 1 GO:0042326 negative regulation of phosphorylation 4/255 385/18722 0.772444173563672 0.849362435744713 PLPP3/TWIST1/PDPK1/HEXIM2 4 GO:0002832 negative regulation of response to biotic stimulus 1/255 108/18722 0.773584708000796 0.849866320851289 NR1H3 1 GO:0006958 complement activation, classical pathway 1/255 108/18722 0.773584708000796 0.849866320851289 CLU 1 GO:0019221 cytokine-mediated signaling pathway 5/255 472/18722 0.773718298503013 0.849866320851289 CXCR2/NR1H3/LIFR/ACSL1/PIAS3 5 GO:1901990 regulation of mitotic cell cycle phase transition 3/255 299/18722 0.776675471664017 0.851511858761365 WEE1/PBX1/KNTC1 3 GO:0032410 negative regulation of transporter activity 1/255 109/18722 0.776686453969411 0.851511858761365 TWIST1 1 GO:0032414 positive regulation of ion transmembrane transporter activity 1/255 109/18722 0.776686453969411 0.851511858761365 EHD3 1 GO:0034766 negative regulation of ion transmembrane transport 1/255 109/18722 0.776686453969411 0.851511858761365 TWIST1 1 GO:0043266 regulation of potassium ion transport 1/255 109/18722 0.776686453969411 0.851511858761365 KCNG1 1 GO:0031667 response to nutrient levels 5/255 474/18722 0.776851298985169 0.851511858761365 ATG7/BMPR2/ACSL1/ABCA1/DNM1L 5 GO:0090174 organelle membrane fusion 1/255 110/18722 0.779745872345696 0.854085471812233 SYT1 1 GO:1904659 glucose transmembrane transport 1/255 110/18722 0.779745872345696 0.854085471812233 IRS1 1 GO:1901987 regulation of cell cycle phase transition 4/255 390/18722 0.781000110317727 0.855159546160791 WEE1/PBX1/SUSD2/KNTC1 4 GO:0050866 negative regulation of cell activation 2/255 210/18722 0.782779991724543 0.856808222115305 NR1H3/GLI3 2 GO:0046474 glycerophospholipid biosynthetic process 2/255 211/18722 0.785002620052201 0.858244516810964 PISD/PTDSS2 2 GO:0010633 negative regulation of epithelial cell migration 1/255 112/18722 0.785740020030774 0.858244516810964 PTPRM 1 GO:0035601 protein deacylation 1/255 112/18722 0.785740020030774 0.858244516810964 SIRT3 1 GO:0043406 positive regulation of MAP kinase activity 1/255 112/18722 0.785740020030774 0.858244516810964 ADAM9 1 GO:0046632 alpha-beta T cell differentiation 1/255 112/18722 0.785740020030774 0.858244516810964 GLI3 1 GO:1901222 regulation of NIK/NF-kappaB signaling 1/255 112/18722 0.785740020030774 0.858244516810964 TLR3 1 GO:0006469 negative regulation of protein kinase activity 2/255 212/18722 0.787205309786065 0.859544581789466 PDPK1/HEXIM2 2 GO:0001578 microtubule bundle formation 1/255 113/18722 0.7886758768224 0.860548922859636 TTLL1 1 GO:0031623 receptor internalization 1/255 113/18722 0.7886758768224 0.860548922859636 CXCR2 1 GO:0002244 hematopoietic progenitor cell differentiation 1/255 114/18722 0.791571661196105 0.862503989273999 JAM3 1 GO:0008645 hexose transmembrane transport 1/255 114/18722 0.791571661196105 0.862503989273999 IRS1 1 GO:0051261 protein depolymerization 1/255 114/18722 0.791571661196105 0.862503989273999 KATNB1 1 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1/255 114/18722 0.791571661196105 0.862503989273999 BMPR2 1 GO:0034660 ncRNA metabolic process 5/255 485/18722 0.793493479662692 0.864109726318976 YARS2/TYW1/TRMT61B/TSEN15/PLD6 5 GO:0043279 response to alkaloid 1/255 115/18722 0.794427917988614 0.864109726318976 ATG7 1 GO:0046916 cellular transition metal ion homeostasis 1/255 115/18722 0.794427917988614 0.864109726318976 S100A8 1 GO:0051209 release of sequestered calcium ion into cytosol 1/255 115/18722 0.794427917988614 0.864109726318976 PDPK1 1 GO:1901989 positive regulation of cell cycle phase transition 1/255 115/18722 0.794427917988614 0.864109726318976 PBX1 1 GO:0015749 monosaccharide transmembrane transport 1/255 116/18722 0.797245184657765 0.86506638960261 IRS1 1 GO:0018107 peptidyl-threonine phosphorylation 1/255 116/18722 0.797245184657765 0.86506638960261 PDPK1 1 GO:0030518 intracellular steroid hormone receptor signaling pathway 1/255 116/18722 0.797245184657765 0.86506638960261 ISL1 1 GO:0031123 RNA 3'-end processing 1/255 116/18722 0.797245184657765 0.86506638960261 SYMPK 1 GO:0051283 negative regulation of sequestering of calcium ion 1/255 116/18722 0.797245184657765 0.86506638960261 PDPK1 1 GO:0098732 macromolecule deacylation 1/255 116/18722 0.797245184657765 0.86506638960261 SIRT3 1 GO:1990748 cellular detoxification 1/255 116/18722 0.797245184657765 0.86506638960261 TXNRD2 1 GO:0007596 blood coagulation 2/255 217/18722 0.797924173550996 0.865502617961424 SERPINE1/F5 2 GO:0042445 hormone metabolic process 2/255 218/18722 0.800009930547217 0.866877591216694 ENPEP/PLB1 2 GO:0051225 spindle assembly 1/255 117/18722 0.800023991382062 0.866877591216694 SPICE1 1 GO:1903828 negative regulation of cellular protein localization 1/255 117/18722 0.800023991382062 0.866877591216694 RAB23 1 GO:0006091 generation of precursor metabolites and energy 5/255 490/18722 0.800732494740611 0.867344556694769 SHPK/IRS1/IDH1/SIRT3/P2RX7 5 GO:0007613 memory 1/255 118/18722 0.802764861158873 0.868642725457576 ITGA3 1 GO:0034219 carbohydrate transmembrane transport 1/255 118/18722 0.802764861158873 0.868642725457576 IRS1 1 GO:0051282 regulation of sequestering of calcium ion 1/255 118/18722 0.802764861158873 0.868642725457576 PDPK1 1 GO:0010906 regulation of glucose metabolic process 1/255 119/18722 0.805468309901321 0.870964867972881 IRS1 1 GO:0031398 positive regulation of protein ubiquitination 1/255 119/18722 0.805468309901321 0.870964867972881 HSPBP1 1 GO:0002768 immune response-regulating cell surface receptor signaling pathway 3/255 315/18722 0.805850501994808 0.871076727337867 PAK3/BCAR1/PTK2 3 GO:0071901 negative regulation of protein serine/threonine kinase activity 1/255 120/18722 0.808134846533862 0.872671771314283 HEXIM2 1 GO:0007599 hemostasis 2/255 222/18722 0.808163873978731 0.872671771314283 SERPINE1/F5 2 GO:0050817 coagulation 2/255 222/18722 0.808163873978731 0.872671771314283 SERPINE1/F5 2 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/255 121/18722 0.810764973086591 0.873567837100184 CLU 1 GO:0042177 negative regulation of protein catabolic process 1/255 121/18722 0.810764973086591 0.873567837100184 USP19 1 GO:0043244 regulation of protein-containing complex disassembly 1/255 121/18722 0.810764973086591 0.873567837100184 KATNB1 1 GO:0043500 muscle adaptation 1/255 121/18722 0.810764973086591 0.873567837100184 LMCD1 1 GO:0045931 positive regulation of mitotic cell cycle 1/255 121/18722 0.810764973086591 0.873567837100184 PBX1 1 GO:0015980 energy derivation by oxidation of organic compounds 3/255 318/18722 0.810950494536843 0.873567837100184 IRS1/IDH1/SIRT3 3 GO:0070661 leukocyte proliferation 3/255 318/18722 0.810950494536843 0.873567837100184 CLU/PTK2/ZNF335 3 GO:0050868 negative regulation of T cell activation 1/255 122/18722 0.813359184788269 0.875558888206456 GLI3 1 GO:0051208 sequestering of calcium ion 1/255 122/18722 0.813359184788269 0.875558888206456 PDPK1 1 GO:0050852 T cell receptor signaling pathway 1/255 123/18722 0.815917970158107 0.877820009510471 BCAR1 1 GO:0002703 regulation of leukocyte mediated immunity 2/255 226/18722 0.816021480840934 0.877820009510471 TLR3/PDPK1 2 GO:0007368 determination of left/right symmetry 1/255 124/18722 0.818441811096313 0.879515357522688 CFAP53 1 GO:0009132 nucleoside diphosphate metabolic process 1/255 124/18722 0.818441811096313 0.879515357522688 P2RX7 1 GO:0010508 positive regulation of autophagy 1/255 124/18722 0.818441811096313 0.879515357522688 ATG7 1 GO:0016032 viral process 4/255 415/18722 0.820021000629554 0.880909462690737 ATG7/ITGAV/SP1/SLC52A1 4 GO:0055007 cardiac muscle cell differentiation 1/255 125/18722 0.82093118297342 0.881281328338007 ISL1 1 GO:2000027 regulation of animal organ morphogenesis 1/255 125/18722 0.82093118297342 0.881281328338007 SIX4 1 GO:0033157 regulation of intracellular protein transport 2/255 229/18722 0.82172518095391 0.881830765961872 GLI3/RAB23 2 GO:0031929 TOR signaling 1/255 126/18722 0.823386554718421 0.882923460854383 DISC1 1 GO:0032874 positive regulation of stress-activated MAPK cascade 1/255 126/18722 0.823386554718421 0.882923460854383 TLR3 1 GO:0045333 cellular respiration 2/255 230/18722 0.823591004284969 0.882923460854383 IDH1/SIRT3 2 GO:0002831 regulation of response to biotic stimulus 3/255 327/18722 0.825578108482503 0.884693594559595 NR1H3/PAK3/ZCCHC3 3 GO:0006911 phagocytosis, engulfment 1/255 127/18722 0.825808388905708 0.884693594559595 ABCA1 1 GO:0035303 regulation of dephosphorylation 1/255 128/18722 0.828197141840855 0.886644764731987 SYMPK 1 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 1/255 128/18722 0.828197141840855 0.886644764731987 TLR3 1 GO:0070371 ERK1 and ERK2 cascade 3/255 330/18722 0.830235295099278 0.887950375946407 GAREM1/SIRT3/ITGAV 3 GO:0006334 nucleosome assembly 1/255 129/18722 0.830553263645232 0.887950375946407 HIRA 1 GO:0007093 mitotic cell cycle checkpoint signaling 1/255 129/18722 0.830553263645232 0.887950375946407 KNTC1 1 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1/255 129/18722 0.830553263645232 0.887950375946407 S100A8 1 GO:0044772 mitotic cell cycle phase transition 4/255 424/18722 0.832598647762139 0.889218054257235 LZTS1/WEE1/PBX1/KNTC1 4 GO:0045930 negative regulation of mitotic cell cycle 2/255 235/18722 0.832660309039492 0.889218054257235 WEE1/KNTC1 2 GO:0006956 complement activation 1/255 130/18722 0.832877198339496 0.889218054257235 CLU 1 GO:0007098 centrosome cycle 1/255 130/18722 0.832877198339496 0.889218054257235 SPICE1 1 GO:0006612 protein targeting to membrane 1/255 131/18722 0.835169383925954 0.890276069383264 BHLHE40-AS1 1 GO:0019827 stem cell population maintenance 1/255 131/18722 0.835169383925954 0.890276069383264 SETD6 1 GO:0046683 response to organophosphorus 1/255 131/18722 0.835169383925954 0.890276069383264 P2RX7 1 GO:0050853 B cell receptor signaling pathway 1/255 131/18722 0.835169383925954 0.890276069383264 BCAR1 1 GO:1903131 mononuclear cell differentiation 4/255 426/18722 0.835292619338154 0.890276069383264 GLI3/PBX1/FANCA/ITGB8 4 GO:0033673 negative regulation of kinase activity 2/255 237/18722 0.836169164150368 0.890906456859836 PDPK1/HEXIM2 2 GO:0006997 nucleus organization 1/255 133/18722 0.839660230179345 0.893711927558056 DDX11 1 GO:0009855 determination of bilateral symmetry 1/255 133/18722 0.839660230179345 0.893711927558056 CFAP53 1 GO:0046328 regulation of JNK cascade 1/255 133/18722 0.839660230179345 0.893711927558056 TLR3 1 GO:0008277 regulation of G protein-coupled receptor signaling pathway 1/255 134/18722 0.84185973748497 0.895138373474152 MET 1 GO:0009799 specification of symmetry 1/255 134/18722 0.84185973748497 0.895138373474152 CFAP53 1 GO:0098727 maintenance of cell number 1/255 134/18722 0.84185973748497 0.895138373474152 SETD6 1 GO:0044843 cell cycle G1/S phase transition 2/255 241/18722 0.842988672367545 0.896033877941693 WEE1/SUSD2 2 GO:1903320 regulation of protein modification by small protein conjugation or removal 2/255 242/18722 0.844652990068629 0.897497651807027 HSPBP1/PIAS3 2 GO:0043401 steroid hormone mediated signaling pathway 1/255 136/18722 0.846168994183996 0.897887302826821 ISL1 1 GO:0043624 cellular protein complex disassembly 1/255 136/18722 0.846168994183996 0.897887302826821 KATNB1 1 GO:0098876 vesicle-mediated transport to the plasma membrane 1/255 136/18722 0.846168994183996 0.897887302826821 EHD3 1 GO:0099024 plasma membrane invagination 1/255 136/18722 0.846168994183996 0.897887302826821 ABCA1 1 GO:0008203 cholesterol metabolic process 1/255 137/18722 0.848279556245929 0.898905938714319 ABCA1 1 GO:0034754 cellular hormone metabolic process 1/255 137/18722 0.848279556245929 0.898905938714319 PLB1 1 GO:0045471 response to ethanol 1/255 137/18722 0.848279556245929 0.898905938714319 S100A8 1 GO:0050671 positive regulation of lymphocyte proliferation 1/255 137/18722 0.848279556245929 0.898905938714319 ZNF335 1 GO:0070663 regulation of leukocyte proliferation 2/255 245/18722 0.849550595839736 0.899891289993088 PTK2/ZNF335 2 GO:0032273 positive regulation of protein polymerization 1/255 138/18722 0.850361273391869 0.899891289993088 MET 1 GO:0032946 positive regulation of mononuclear cell proliferation 1/255 138/18722 0.850361273391869 0.899891289993088 ZNF335 1 GO:0055076 transition metal ion homeostasis 1/255 138/18722 0.850361273391869 0.899891289993088 S100A8 1 GO:0033002 muscle cell proliferation 2/255 248/18722 0.854307776097269 0.902984167202114 GJA1/BMPR2 2 GO:0045936 negative regulation of phosphate metabolic process 4/255 441/18722 0.854367606633824 0.902984167202114 PLPP3/TWIST1/PDPK1/HEXIM2 4 GO:0007292 female gamete generation 1/255 140/18722 0.854439738373328 0.902984167202114 PLD6 1 GO:0050768 negative regulation of neurogenesis 1/255 140/18722 0.854439738373328 0.902984167202114 SEMA4G 1 GO:0010563 negative regulation of phosphorus metabolic process 4/255 442/18722 0.85557023674284 0.90387248362734 PLPP3/TWIST1/PDPK1/HEXIM2 4 GO:0016241 regulation of macroautophagy 1/255 141/18722 0.856437255686578 0.90387248362734 LZTS1 1 GO:0032355 response to estradiol 1/255 141/18722 0.856437255686578 0.90387248362734 GJA1 1 GO:1903038 negative regulation of leukocyte cell-cell adhesion 1/255 141/18722 0.856437255686578 0.90387248362734 GLI3 1 GO:0097553 calcium ion transmembrane import into cytosol 1/255 142/18722 0.858407467182187 0.905278076154902 PDPK1 1 GO:2000045 regulation of G1/S transition of mitotic cell cycle 1/255 142/18722 0.858407467182187 0.905278076154902 WEE1 1 GO:0042742 defense response to bacterium 3/255 350/18722 0.858640819941447 0.905278076154902 TLR3/S100A8/SERPINE1 3 GO:0006302 double-strand break repair 2/255 251/18722 0.858927838655771 0.905278076154902 TWIST1/DDX11 2 GO:0031023 microtubule organizing center organization 1/255 143/18722 0.860350744677803 0.905647898385851 SPICE1 1 GO:0034763 negative regulation of transmembrane transport 1/255 143/18722 0.860350744677803 0.905647898385851 TWIST1 1 GO:0038061 NIK/NF-kappaB signaling 1/255 143/18722 0.860350744677803 0.905647898385851 TLR3 1 GO:0010951 negative regulation of endopeptidase activity 2/255 252/18722 0.860437955298429 0.905647898385851 CRIM1/SERPINE1 2 GO:0034612 response to tumor necrosis factor 2/255 253/18722 0.86193332052072 0.906657401316294 PIAS3/ADAM9 2 GO:0007612 learning 1/255 144/18722 0.862267454947848 0.906657401316294 NRXN3 1 GO:0010324 membrane invagination 1/255 144/18722 0.862267454947848 0.906657401316294 ABCA1 1 GO:0051961 negative regulation of nervous system development 1/255 145/18722 0.864157959791658 0.908339597830115 SEMA4G 1 GO:0006338 chromatin remodeling 2/255 255/18722 0.864880274862688 0.908487683679295 HIRA/KDM5B 2 GO:0007611 learning or memory 2/255 255/18722 0.864880274862688 0.908487683679295 NRXN3/ITGA3 2 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/255 146/18722 0.866022616100703 0.909076478103694 ABCA1 1 GO:0010675 regulation of cellular carbohydrate metabolic process 1/255 146/18722 0.866022616100703 0.909076478103694 IRS1 1 GO:0030217 T cell differentiation 2/255 257/18722 0.867769652864629 0.910604487979169 GLI3/FANCA 2 GO:0031348 negative regulation of defense response 2/255 258/18722 0.869193045694062 0.911075036182163 NR1H3/ISL1 2 GO:0042593 glucose homeostasis 2/255 258/18722 0.869193045694062 0.911075036182163 EFNA5/IRS1 2 GO:0014074 response to purine-containing compound 1/255 148/18722 0.869675786538046 0.911075036182163 P2RX7 1 GO:0050905 neuromuscular process 1/255 148/18722 0.869675786538046 0.911075036182163 TNNT3 1 GO:2001056 positive regulation of cysteine-type endopeptidase activity 1/255 148/18722 0.869675786538046 0.911075036182163 S100A8 1 GO:0033500 carbohydrate homeostasis 2/255 259/18722 0.870602397314617 0.911740111128746 EFNA5/IRS1 2 GO:0090150 establishment of protein localization to membrane 2/255 260/18722 0.871997824223258 0.912895544622338 BHLHE40-AS1/TIMM8A 2 GO:0007346 regulation of mitotic cell cycle 4/255 457/18722 0.87262306274893 0.913244163124717 BTC/WEE1/PBX1/KNTC1 4 GO:0001959 regulation of cytokine-mediated signaling pathway 1/255 150/18722 0.873229725732077 0.913423948254434 NR1H3 1 GO:0051321 meiotic cell cycle 2/255 261/18722 0.87337944236296 0.913423948254434 FANCA/PLD6 2 GO:0010466 negative regulation of peptidase activity 2/255 262/18722 0.874747367116159 0.914475674703651 CRIM1/SERPINE1 2 GO:0071333 cellular response to glucose stimulus 1/255 151/18722 0.874970325556453 0.914475674703651 EFNA5 1 GO:0008643 carbohydrate transport 1/255 152/18722 0.876687118781541 0.915351569058575 IRS1 1 GO:0016125 sterol metabolic process 1/255 152/18722 0.876687118781541 0.915351569058575 ABCA1 1 GO:0098754 detoxification 1/255 152/18722 0.876687118781541 0.915351569058575 TXNRD2 1 GO:0071331 cellular response to hexose stimulus 1/255 153/18722 0.878380429751423 0.916507126201401 EFNA5 1 GO:0120254 olefinic compound metabolic process 1/255 153/18722 0.878380429751423 0.916507126201401 PLB1 1 GO:0030856 regulation of epithelial cell differentiation 1/255 154/18722 0.880050578408506 0.917330906446492 SERPINE1 1 GO:0051168 nuclear export 1/255 154/18722 0.880050578408506 0.917330906446492 XPOT 1 GO:0071326 cellular response to monosaccharide stimulus 1/255 154/18722 0.880050578408506 0.917330906446492 EFNA5 1 GO:0034614 cellular response to reactive oxygen species 1/255 155/18722 0.881697880353026 0.91874153921414 MET 1 GO:0051348 negative regulation of transferase activity 2/255 268/18722 0.882673743781883 0.919451816439462 PDPK1/HEXIM2 2 GO:0046631 alpha-beta T cell activation 1/255 156/18722 0.88332264690174 0.919821150139266 GLI3 1 GO:0051250 negative regulation of lymphocyte activation 1/255 157/18722 0.884925185145845 0.92056964167136 GLI3 1 GO:1902600 proton transmembrane transport 1/255 157/18722 0.884925185145845 0.92056964167136 TWIST1 1 GO:2000377 regulation of reactive oxygen species metabolic process 1/255 157/18722 0.884925185145845 0.92056964167136 SIRT3 1 GO:0030098 lymphocyte differentiation 3/255 374/18722 0.887180959703468 0.922609151105936 GLI3/PBX1/FANCA 3 GO:0048872 homeostasis of number of cells 2/255 272/18722 0.887698449973226 0.922840204978819 CXCR2/JAM3 2 GO:0035966 response to topologically incorrect protein 1/255 159/18722 0.8880647842992 0.922914017603924 CLU 1 GO:0034249 negative regulation of cellular amide metabolic process 2/255 273/18722 0.888923196646855 0.923498999176005 CLU/GRB7 2 GO:0044282 small molecule catabolic process 3/255 376/18722 0.889311085883756 0.923590571816189 ACADS/IRS1/TWIST1 3 GO:0090316 positive regulation of intracellular protein transport 1/255 160/18722 0.889602438773353 0.923590571816189 GLI3 1 GO:0051650 establishment of vesicle localization 1/255 161/18722 0.891119052183158 0.924857867177804 MYO5B 1 GO:0060759 regulation of response to cytokine stimulus 1/255 162/18722 0.892614911333704 0.926096183228333 NR1H3 1 GO:0046034 ATP metabolic process 2/255 277/18722 0.893699710960105 0.926096183228333 P2RX7/DNM1L 2 GO:0050657 nucleic acid transport 1/255 163/18722 0.894090299135962 0.926096183228333 XPOT 1 GO:0050658 RNA transport 1/255 163/18722 0.894090299135962 0.926096183228333 XPOT 1 GO:0071322 cellular response to carbohydrate stimulus 1/255 163/18722 0.894090299135962 0.926096183228333 EFNA5 1 GO:0072331 signal transduction by p53 class mediator 1/255 163/18722 0.894090299135962 0.926096183228333 TWIST1 1 GO:0002700 regulation of production of molecular mediator of immune response 1/255 164/18722 0.895545494659446 0.927296113588724 TLR3 1 GO:0006470 protein dephosphorylation 2/255 281/18722 0.898285367190311 0.929632042893118 PTPRM/SYMPK 2 GO:0051236 establishment of RNA localization 1/255 166/18722 0.89839640625191 0.929632042893118 XPOT 1 GO:0007254 JNK cascade 1/255 167/18722 0.89979266171676 0.930460644561507 TLR3 1 GO:0034728 nucleosome organization 1/255 167/18722 0.89979266171676 0.930460644561507 HIRA 1 GO:0006520 cellular amino acid metabolic process 2/255 284/18722 0.901603374236165 0.931716449896831 CTPS2/YARS2 2 GO:0022409 positive regulation of cell-cell adhesion 2/255 284/18722 0.901603374236165 0.931716449896831 GLI3/PLPP3 2 GO:0000075 cell cycle checkpoint signaling 1/255 169/18722 0.902528093114432 0.932363732556232 KNTC1 1 GO:0007259 receptor signaling pathway via JAK-STAT 1/255 170/18722 0.903867786762674 0.933439138675927 ISL1 1 GO:0034599 cellular response to oxidative stress 2/255 288/18722 0.905870967295398 0.935198801717251 MET/ATG7 2 GO:0001678 cellular glucose homeostasis 1/255 172/18722 0.906492397983009 0.935222431065336 EFNA5 1 GO:0042770 signal transduction in response to DNA damage 1/255 172/18722 0.906492397983009 0.935222431065336 TWIST1 1 GO:0034470 ncRNA processing 3/255 395/18722 0.907824299495635 0.936287437598634 TYW1/TRMT61B/TSEN15 3 GO:0043405 regulation of MAP kinase activity 1/255 177/18722 0.912745837299761 0.940742329011132 ADAM9 1 GO:0051648 vesicle localization 1/255 177/18722 0.912745837299761 0.940742329011132 MYO5B 1 GO:0050890 cognition 2/255 296/18722 0.913893584256998 0.941357955095499 NRXN3/ITGA3 2 GO:0035265 organ growth 1/255 178/18722 0.913945611443118 0.941357955095499 GJA1 1 GO:0010950 positive regulation of endopeptidase activity 1/255 179/18722 0.915128952096807 0.942266219210057 S100A8 1 GO:0097696 receptor signaling pathway via STAT 1/255 181/18722 0.917447226759565 0.94425096742308 ISL1 1 GO:0016050 vesicle organization 2/255 300/18722 0.917660860180447 0.94425096742308 SYT1/ABCA1 2 GO:0140013 meiotic nuclear division 1/255 185/18722 0.921896237923512 0.948296821432184 FANCA 1 GO:1902115 regulation of organelle assembly 1/255 186/18722 0.922970654459603 0.949089600258723 SPICE1 1 GO:0001906 cell killing 1/255 188/18722 0.925075520099143 0.950941118522967 P2RX7 1 GO:0070372 regulation of ERK1 and ERK2 cascade 2/255 309/18722 0.925579929826809 0.95099639622629 GAREM1/SIRT3 2 GO:0016311 dephosphorylation 3/255 417/18722 0.92573793194252 0.95099639622629 PLPP3/PTPRM/SYMPK 3 GO:0032872 regulation of stress-activated MAPK cascade 1/255 192/18722 0.92911491377869 0.954151858546962 TLR3 1 GO:0050777 negative regulation of immune response 1/255 194/18722 0.93105250730054 0.95582755759336 NR1H3 1 GO:0070302 regulation of stress-activated protein kinase signaling cascade 1/255 195/18722 0.932001428427395 0.955871232157174 TLR3 1 GO:1901605 alpha-amino acid metabolic process 1/255 195/18722 0.932001428427395 0.955871232157174 CTPS2 1 GO:0019058 viral life cycle 2/255 317/18722 0.932012686202531 0.955871232157174 ITGAV/SLC52A1 2 GO:0006006 glucose metabolic process 1/255 196/18722 0.932937340110399 0.956505639056757 IRS1 1 GO:0010952 positive regulation of peptidase activity 1/255 197/18722 0.933860420012798 0.957138016575924 S100A8 1 GO:0052548 regulation of endopeptidase activity 3/255 432/18722 0.936065376877157 0.959083377947906 S100A8/CRIM1/SERPINE1 3 GO:0006403 RNA localization 1/255 201/18722 0.937427891178032 0.960164588636955 XPOT 1 GO:0032388 positive regulation of intracellular transport 1/255 202/18722 0.938289393675176 0.96041741082048 GLI3 1 GO:1903046 meiotic cell cycle process 1/255 202/18722 0.938289393675176 0.96041741082048 FANCA 1 GO:0071383 cellular response to steroid hormone stimulus 1/255 204/18722 0.939977113818525 0.961829888894201 ISL1 1 GO:0050863 regulation of T cell activation 2/255 329/18722 0.940686433684253 0.962240623654105 GLI3/FANCA 2 GO:0002443 leukocyte mediated immunity 3/255 440/18722 0.941017294284895 0.962264085288056 TLR3/CLU/PDPK1 3 GO:0071214 cellular response to abiotic stimulus 2/255 331/18722 0.942026153275966 0.962665706012883 TLR3/GJA1 2 GO:0104004 cellular response to environmental stimulus 2/255 331/18722 0.942026153275966 0.962665706012883 TLR3/GJA1 2 GO:0016064 immunoglobulin mediated immune response 1/255 207/18722 0.942422870406553 0.962756283105746 CLU 1 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1/255 209/18722 0.943997966616484 0.964050211005396 S100A8 1 GO:0019724 B cell mediated immunity 1/255 210/18722 0.94476934448678 0.964207773194379 CLU 1 GO:0031396 regulation of protein ubiquitination 1/255 210/18722 0.94476934448678 0.964207773194379 HSPBP1 1 GO:0032386 regulation of intracellular transport 2/255 337/18722 0.945875376785933 0.964706446624034 GLI3/RAB23 2 GO:0062197 cellular response to chemical stress 2/255 337/18722 0.945875376785933 0.964706446624034 MET/ATG7 2 GO:0018209 peptidyl-serine modification 2/255 338/18722 0.946492861467149 0.965021269848235 GALNT3/PDPK1 2 GO:0002697 regulation of immune effector process 2/255 339/18722 0.947103655427325 0.965329068235614 TLR3/PDPK1 2 GO:0000082 G1/S transition of mitotic cell cycle 1/255 214/18722 0.947750453269327 0.96567335065753 WEE1 1 GO:0050870 positive regulation of T cell activation 1/255 216/18722 0.949180343485646 0.966815049997602 GLI3 1 GO:0070374 positive regulation of ERK1 and ERK2 cascade 1/255 217/18722 0.949880603531639 0.967213061595429 GAREM1 1 GO:0071805 potassium ion transmembrane transport 1/255 219/18722 0.951252419692666 0.968294401152958 KCNG1 1 GO:0022618 ribonucleoprotein complex assembly 1/255 220/18722 0.951924236856281 0.968347408911419 PRMT7 1 GO:0031503 protein-containing complex localization 1/255 220/18722 0.951924236856281 0.968347408911419 XPOT 1 GO:0052547 regulation of peptidase activity 3/255 461/18722 0.952380504379664 0.96849628252081 S100A8/CRIM1/SERPINE1 3 GO:0032984 protein-containing complex disassembly 1/255 224/18722 0.954520529455692 0.970356751642498 KATNB1 1 GO:0006364 rRNA processing 1/255 225/18722 0.955147476422326 0.970362764570797 TRMT61B 1 GO:0050670 regulation of lymphocyte proliferation 1/255 225/18722 0.955147476422326 0.970362764570797 ZNF335 1 GO:0032944 regulation of mononuclear cell proliferation 1/255 227/18722 0.956375660492316 0.970979187471893 ZNF335 1 GO:0071826 ribonucleoprotein complex subunit organization 1/255 227/18722 0.956375660492316 0.970979187471893 PRMT7 1 GO:0071356 cellular response to tumor necrosis factor 1/255 229/18722 0.957570341825017 0.97187636187177 PIAS3 1 GO:0051251 positive regulation of lymphocyte activation 2/255 362/18722 0.959451783227562 0.973469747592899 GLI3/ZNF335 2 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1/255 233/18722 0.959862813221355 0.973570688515656 ABCA1 1 GO:0043410 positive regulation of MAPK cascade 3/255 480/18722 0.960873653969519 0.973651992575317 GAREM1/TLR3/ADAM9 3 GO:0002699 positive regulation of immune effector process 1/255 235/18722 0.960962350811396 0.973651992575317 PDPK1 1 GO:2000116 regulation of cysteine-type endopeptidase activity 1/255 235/18722 0.960962350811396 0.973651992575317 S100A8 1 GO:0000209 protein polyubiquitination 1/255 236/18722 0.961500815707977 0.973651992575317 KLHL42 1 GO:0016072 rRNA metabolic process 1/255 236/18722 0.961500815707977 0.973651992575317 TRMT61B 1 GO:0019318 hexose metabolic process 1/255 237/18722 0.962031882028136 0.973865717246543 IRS1 1 GO:0051403 stress-activated MAPK cascade 1/255 239/18722 0.96307222260918 0.973865717246543 TLR3 1 GO:0072593 reactive oxygen species metabolic process 1/255 239/18722 0.96307222260918 0.973865717246543 SIRT3 1 GO:1903039 positive regulation of leukocyte cell-cell adhesion 1/255 239/18722 0.96307222260918 0.973865717246543 GLI3 1 GO:0007159 leukocyte cell-cell adhesion 2/255 371/18722 0.963490324299276 0.973865717246543 S100A8/GLI3 2 GO:0050851 antigen receptor-mediated signaling pathway 1/255 240/18722 0.96358169527242 0.973865717246543 BCAR1 1 GO:0006813 potassium ion transport 1/255 241/18722 0.96408416620119 0.974058525502334 KCNG1 1 GO:0017148 negative regulation of translation 1/255 245/18722 0.966025930109637 0.975704922945254 GRB7 1 GO:0051346 negative regulation of hydrolase activity 2/255 379/18722 0.966754413931951 0.976014648486408 CRIM1/SERPINE1 2 GO:0031098 stress-activated protein kinase signaling cascade 1/255 247/18722 0.966957232548454 0.976014648486408 TLR3 1 GO:0005996 monosaccharide metabolic process 1/255 257/18722 0.971245828437391 0.980026869185291 IRS1 1 GO:0002696 positive regulation of leukocyte activation 2/255 409/18722 0.976673958867826 0.985185965610702 GLI3/ZNF335 2 GO:0002366 leukocyte activation involved in immune response 1/255 275/18722 0.97761578623119 0.985817790246038 PDPK1 1 GO:0002263 cell activation involved in immune response 1/255 279/18722 0.978828157102356 0.986721932562858 PDPK1 1 GO:0050867 positive regulation of cell activation 2/255 420/18722 0.979540045914943 0.987121136241277 GLI3/ZNF335 2 GO:0046651 lymphocyte proliferation 1/255 288/18722 0.981322136928949 0.988598219826875 ZNF335 1 GO:0032943 mononuclear cell proliferation 1/255 291/18722 0.982086625097341 0.989049533815402 ZNF335 1 GO:0008380 RNA splicing 2/255 434/18722 0.982699055269393 0.989347470269605 PRMT7/TSEN15 2 GO:0042254 ribosome biogenesis 1/255 299/18722 0.983976275268352 0.990314286703253 TRMT61B 1 GO:0002440 production of molecular mediator of immune response 1/255 308/18722 0.985865759306794 0.991896489965786 TLR3 1 GO:0018105 peptidyl-serine phosphorylation 1/255 315/18722 0.987180471427944 0.992171704462914 PDPK1 1 GO:0006959 humoral immune response 1/255 317/18722 0.987533209416101 0.992171704462914 CLU 1 GO:0022613 ribonucleoprotein complex biogenesis 2/255 463/18722 0.98781139683914 0.992171704462914 PRMT7/TRMT61B 2 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1/255 320/18722 0.988044270172348 0.992171704462914 PRMT7 1 GO:0000398 mRNA splicing, via spliceosome 1/255 320/18722 0.988044270172348 0.992171704462914 PRMT7 1 GO:0009416 response to light stimulus 1/255 320/18722 0.988044270172348 0.992171704462914 EYS 1 GO:0006417 regulation of translation 2/255 468/18722 0.98852993378197 0.992185859713476 GRB7/ZNF598 2 GO:0000375 RNA splicing, via transesterification reactions 1/255 324/18722 0.988693365487284 0.992185859713476 PRMT7 1 GO:1903037 regulation of leukocyte cell-cell adhesion 1/255 336/18722 0.990437459665848 0.993617034175209 GLI3 1 GO:0042110 T cell activation 2/255 487/18722 0.990903341375142 0.993765385685917 GLI3/FANCA 2 GO:0002449 lymphocyte mediated immunity 1/255 350/18722 0.99213631581349 0.994682703534538 CLU 1 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/255 356/18722 0.99276897010334 0.994779344605914 CLU 1 GO:0001818 negative regulation of cytokine production 1/255 357/18722 0.99286936826427 0.994779344605914 TWIST1 1 GO:0034655 nucleobase-containing compound catabolic process 1/255 407/18722 0.996459250095614 0.998056139919485 PDE10A 1 GO:0046700 heterocycle catabolic process 1/255 445/18722 0.997922835799667 0.998795032651237 PDE10A 1 GO:0044270 cellular nitrogen compound catabolic process 1/255 451/18722 0.998090787690267 0.998795032651237 PDE10A 1 GO:0009314 response to radiation 1/255 456/18722 0.998220364179184 0.998795032651237 EYS 1 GO:0019439 aromatic compound catabolic process 1/255 467/18722 0.998475418240788 0.998795032651237 PDE10A 1 GO:1901361 organic cyclic compound catabolic process 1/255 495/18722 0.998972073904458 0.998972073904458 PDE10A 1