ID Description GeneRatio BgRatio pvalue p.adjust geneID geneName Count hsa03010 Ribosome 34/350 91/5868 2.52490616504203e-19 4.62057828202692e-17 6227/6175/6224/23521/6147/6189/6207/6205/6157/6204/6194/6217/6160/6128/9045/6129/6144/6230/6152/6143/6137/6142/6133/6138/6231/7311/6154/9349/6187/6124/6122/6139/6218/6192 RPS21/RPLP0/RPS20/RPL13A/RPL23A/RPS3A/RPS13/RPS11/RPL27A/RPS10/RPS6/RPS16/RPL31/RPL6/RPL14/RPL7/RPL21/RPS25/RPL24/RPL19/RPL13/RPL18A/RPL9/RPL15/RPS26/UBA52/RPL26/RPL23/RPS2/RPL4/RPL3/RPL17/RPS17/RPS4Y1 34 hsa04141 Protein processing in endoplasmic reticulum 36/350 165/5868 3.85846192319308e-12 3.53049265972167e-10 7184/6238/3309/3998/6185/5034/23193/2923/7095/10961/1650/64374/9601/10970/23645/811/3303/10956/821/10905/3304/10960/7841/7991/22926/8720/29927/10130/11231/1649/440275/5589/6184/3337/6500/10134 HSP90B1/RRBP1/HSPA5/LMAN1/RPN2/P4HB/GANAB/PDIA3/SEC62/ERP29/DDOST/SIL1/PDIA4/CKAP4/PPP1R15A/CALR/HSPA1A/OS9/CANX/MAN1A2/HSPA1B/LMAN2/MOGS/TUSC3/ATF6/MBTPS1/SEC61A1/PDIA6/SEC63/DDIT3/EIF2AK4/PRKCSH/RPN1/DNAJB1/SKP1/BCAP31 36 hsa04142 Lysosome 25/350 121/5868 2.83367806060312e-08 1.7285436169679e-06 1514/5660/2548/1509/1075/3073/1515/537/4669/2517/4126/5476/5641/2990/2799/2720/3920/427/79158/3916/533/1213/1201/3074/1211 CTSL/PSAP/GAA/CTSD/CTSC/HEXA/CTSV/ATP6AP1/NAGLU/FUCA1/MANBA/CTSA/LGMN/GUSB/GNS/GLB1/LAMP2/ASAH1/GNPTAB/LAMP1/ATP6V0B/CLTC/CLN3/HEXB/CLTA 25 hsa04520 Adherens junction 15/350 73/5868 1.93433129321164e-05 0.000884956566644326 1956/999/4233/8826/3480/5792/71/4008/1500/81/10163/6934/998/387/1460 EGFR/CDH1/MET/IQGAP1/IGF1R/PTPRF/ACTG1/LMO7/CTNND1/ACTN4/WASF2/TCF7L2/CDC42/RHOA/CSNK2B 15 hsa04510 Focal adhesion 25/350 200/5868 0.000308014878809757 0.00995856305635509 3725/1956/3691/3911/3685/3912/3688/3655/3915/4233/1284/857/2321/3480/3693/71/1729/81/6093/394/103910/7094/998/10627/387 JUN/EGFR/ITGB4/LAMA5/ITGAV/LAMB1/ITGB1/ITGA6/LAMC1/MET/COL4A2/CAV1/FLT1/IGF1R/ITGB5/ACTG1/DIAPH1/ACTN4/ROCK1/ARHGAP5/MYL12B/TLN1/CDC42/MYL12A/RHOA 25 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 13/350 74/5868 0.000365547183401836 0.00995856305635509 3691/3685/3688/1605/3655/2697/1832/1829/1824/3693/71/81/6934 ITGB4/ITGAV/ITGB1/DAG1/ITGA6/GJA1/DSP/DSG2/DSC2/ITGB5/ACTG1/ACTN4/TCF7L2 13 hsa05130 Pathogenic Escherichia coli infection 11/350 56/5868 0.000380928641499921 0.00995856305635509 999/3688/71/6093/3875/998/10094/84790/387/10376/10383 CDH1/ITGB1/ACTG1/ROCK1/KRT18/CDC42/ARPC3/TUBA1C/RHOA/TUBA1B/TUBB4B 11 hsa00531 Glycosaminoglycan degradation 6/350 19/5868 0.000602234937443136 0.0137761241940117 3073/4669/2990/2799/2720/3074 HEXA/NAGLU/GUSB/GNS/GLB1/HEXB 6 hsa04145 Phagosome 20/350 153/5868 0.000691109610411258 0.0140525620783623 1514/3685/3688/1778/7037/8411/81035/537/811/3693/71/821/3920/29927/3916/525/533/84790/10376/10383 CTSL/ITGAV/ITGB1/DYNC1H1/TFRC/EEA1/COLEC12/ATP6AP1/CALR/ITGB5/ACTG1/CANX/LAMP2/SEC61A1/LAMP1/ATP6V1B1/ATP6V0B/TUBA1C/TUBA1B/TUBB4B 20 hsa04810 Regulation of actin cytoskeleton 24/350 213/5868 0.00179239609108932 0.0328008484669346 1956/3691/3685/3688/3655/10788/4628/8826/5216/7114/6548/3693/71/1729/81/10163/6093/1072/2768/103910/998/10094/10627/387 EGFR/ITGB4/ITGAV/ITGB1/ITGA6/IQGAP2/MYH10/IQGAP1/PFN1/TMSB4X/SLC9A1/ITGB5/ACTG1/DIAPH1/ACTN4/WASF2/ROCK1/CFL1/GNA12/MYL12B/CDC42/ARPC3/MYL12A/RHOA 24 hsa00510 N-Glycan biosynthesis 9/350 49/5868 0.00211223326676612 0.0351398807107455 6185/23193/1650/4124/10905/7841/7991/2530/6184 RPN2/GANAB/DDOST/MAN2A1/MAN1A2/MOGS/TUSC3/FUT8/RPN1 9 hsa00511 Other glycan degradation 5/350 17/5868 0.00249878814226643 0.0368117922978989 3073/2517/4126/2720/3074 HEXA/FUCA1/MANBA/GLB1/HEXB 5 hsa05100 Bacterial invasion of epithelial cells 11/350 70/5868 0.00261504535449555 0.0368117922978989 999/3688/4233/857/71/10163/1213/998/10094/1211/387 CDH1/ITGB1/MET/CAV1/ACTG1/WASF2/CLTC/CDC42/ARPC3/CLTA/RHOA 11 hsa03040 Spliceosome 16/350 127/5868 0.00339983377628586 0.0444406843614509 55119/58517/6430/3303/6434/3304/3178/6432/9879/57187/6431/23451/1655/6633/3183/6631 PRPF38B/RBM25/SRSF5/HSPA1A/TRA2B/HSPA1B/HNRNPA1/SRSF7/DDX46/THOC2/SRSF6/SF3B1/DDX5/SNRPD2/HNRNPC/SNRPC 16 hsa05131 Shigellosis 9/350 61/5868 0.0095002458733234 0.11568466808904 3688/5216/71/1729/10163/6093/4792/998/10094 ITGB1/PFN1/ACTG1/DIAPH1/WASF2/ROCK1/NFKBIA/CDC42/ARPC3 9 hsa03060 Protein export 5/350 23/5868 0.0101145064995882 0.11568466808904 3309/7095/29927/11231/9789 HSPA5/SEC62/SEC61A1/SEC63/SPCS2 5 hsa05222 Small cell lung cancer 11/350 85/5868 0.0116126143213285 0.1250063776943 3911/3685/3912/3688/3655/3915/1284/1021/4792/1163/898 LAMA5/ITGAV/LAMB1/ITGB1/ITGA6/LAMC1/COL4A2/CDK6/NFKBIA/CKS1B/CCNE1 11 hsa04970 Salivary secretion 11/350 89/5868 0.0160872145789584 0.163553348219411 490/3783/493/6548/153/1471/476/2776/6844/801/805 ATP2B1/KCNN4/ATP2B4/SLC9A1/ADRB1/CST3/ATP1A1/GNAQ/VAMP2/CALM1/CALM2 11 hsa03013 RNA transport 16/350 151/5868 0.0173701910329033 0.167302366264279 1915/8661/7175/5411/26019/1981/5903/8667/57187/3837/5901/10209/8894/8665/8668/1975 EEF1A1/EIF3A/TPR/PNN/UPF2/EIF4G1/RANBP2/EIF3H/THOC2/KPNB1/RAN/EIF1/EIF2S2/EIF3F/EIF3I/EIF4B 16 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 9/350 68/5868 0.0187487746866642 0.171551288382978 3725/1956/4233/537/83700/525/4792/533/998 JUN/EGFR/MET/ATP6AP1/JAM3/ATP6V1B1/NFKBIA/ATP6V0B/CDC42 9 hsa04512 ECM-receptor interaction 10/350 85/5868 0.0289038564924036 0.251876463719517 3691/3911/3685/3912/3688/1605/3655/3915/1284/3693 ITGB4/LAMA5/ITGAV/LAMB1/ITGB1/DAG1/ITGA6/LAMC1/COL4A2/ITGB5 10 hsa04612 Antigen processing and presentation 9/350 76/5868 0.0358256685700937 0.298004424923962 1514/3309/2923/811/3303/5641/821/3304/5721 CTSL/HSPA5/PDIA3/CALR/HSPA1A/LGMN/CANX/HSPA1B/PSME2 9 hsa04670 Leukocyte transendothelial migration 12/350 116/5868 0.042788327404584 0.340446257175604 3688/1364/83700/71/1500/81/6093/394/103910/998/10627/387 ITGB1/CLDN4/JAM3/ACTG1/CTNND1/ACTN4/ROCK1/ARHGAP5/MYL12B/CDC42/MYL12A/RHOA 12 hsa04974 Protein digestion and absorption 9/350 81/5868 0.0507235246186691 0.386766875217352 7373/3783/1284/6520/54407/6510/1803/4311/476 COL14A1/KCNN4/COL4A2/SLC3A2/SLC38A2/SLC1A5/DPP4/MME/ATP1A1 9 hsa00604 Glycosphingolipid biosynthesis - ganglio series 3/350 15/5868 0.056076504742573 0.410480014715634 3073/2720/3074 HEXA/GLB1/HEXB 3 hsa05200 Pathways in cancer 26/350 326/5868 0.076659928242439 0.52063099253009 3725/1956/7184/2353/1441/999/3911/3685/6513/3912/3688/3655/3915/4233/1284/3480/7175/1021/2737/6934/4792/2034/998/387/1163/898 JUN/EGFR/HSP90B1/FOS/CSF3R/CDH1/LAMA5/ITGAV/SLC2A1/LAMB1/ITGB1/ITGA6/LAMC1/MET/COL4A2/IGF1R/TPR/CDK6/GLI3/TCF7L2/NFKBIA/EPAS1/CDC42/RHOA/CKS1B/CCNE1 26 hsa04614 Renin-angiotensin system 3/350 17/5868 0.0768144087339477 0.52063099253009 2028/5476/4311 ENPEP/CTSA/MME 3 hsa04360 Axon guidance 12/350 129/5868 0.0823221550791663 0.535232914266891 3688/57556/4233/2050/80031/8829/10725/5921/6093/1072/998/387 ITGB1/SEMA6A/MET/EPHB4/SEMA6D/NRP1/NFAT5/RASA1/ROCK1/CFL1/CDC42/RHOA 12 hsa05414 Dilated cardiomyopathy 9/350 90/5868 0.0866953928437353 0.535232914266891 3691/3685/3688/1605/3655/3693/71/153/7171 ITGB4/ITGAV/ITGB1/DAG1/ITGA6/ITGB5/ACTG1/ADRB1/TPM4 9 hsa04144 Endocytosis 17/350 201/5868 0.0902704340006713 0.535232914266891 1956/4233/7037/857/8411/2321/3480/2348/3303/153/3304/2065/1213/998/1211/387/8766 EGFR/MET/TFRC/CAV1/EEA1/FLT1/IGF1R/FOLR1/HSPA1A/ADRB1/HSPA1B/ERBB3/CLTC/CDC42/CLTA/RHOA/RAB11A 17 hsa00010 Glycolysis / Gluconeogenesis 7/350 65/5868 0.0906678707228068 0.535232914266891 2597/3939/226/84532/7167/2023/5315 GAPDH/LDHA/ALDOA/ACSS1/TPI1/ENO1/PKM 7 hsa04530 Tight junction 12/350 132/5868 0.0939263740560475 0.537141451633022 1364/4628/6709/83700/71/55870/81/103910/998/10627/387/1460 CLDN4/MYH10/SPTAN1/JAM3/ACTG1/ASH1L/ACTN4/MYL12B/CDC42/MYL12A/RHOA/CSNK2B 12 hsa05110 Vibrio cholerae infection 6/350 54/5868 0.100454530500622 0.557066032776176 9601/537/71/29927/525/533 PDIA4/ATP6AP1/ACTG1/SEC61A1/ATP6V1B1/ATP6V0B 6 hsa04962 Vasopressin-regulated water reabsorption 5/350 44/5868 0.119112565582627 0.623797177600452 1778/8655/64764/6844/8766 DYNC1H1/DYNLL1/CREB3L2/VAMP2/RAB11A 5 hsa05410 Hypertrophic cardiomyopathy (HCM) 8/350 83/5868 0.120212351410824 0.623797177600452 3691/3685/3688/1605/3655/3693/71/7171 ITGB4/ITGAV/ITGB1/DAG1/ITGA6/ITGB5/ACTG1/TPM4 8 hsa05010 Alzheimer's disease 14/350 167/5868 0.12271419887222 0.623797177600452 2597/4035/351/1337/4311/23385/2776/22926/4715/801/7388/341947/805/9377 GAPDH/LRP1/APP/COX6A1/MME/NCSTN/GNAQ/ATF6/NDUFB9/CALM1/UQCRH/COX8C/CALM2/COX5A 14 hsa05016 Huntington's disease 15/350 183/5868 0.129535923051789 0.640677673472361 1337/548644/64764/2776/5430/4715/7416/2876/1213/7388/7052/1211/341947/9377/7417 COX6A1/POLR2J3/CREB3L2/GNAQ/POLR2A/NDUFB9/VDAC1/GPX1/CLTC/UQCRH/TGM2/CLTA/COX8C/COX5A/VDAC2 15 hsa05020 Prion diseases 4/350 35/5868 0.153048098568253 0.737047422052377 3309/3915/1958/3303 HSPA5/LAMC1/EGR1/HSPA1A 4 hsa04977 Vitamin digestion and absorption 3/350 24/5868 0.169395633055628 0.765981696527524 6573/80704/113278 SLC19A1/SLC19A3/SLC52A3 3 hsa04260 Cardiac muscle contraction 7/350 77/5868 0.17389096997402 0.765981696527524 1337/6548/476/7388/7171/341947/9377 COX6A1/SLC9A1/ATP1A1/UQCRH/TPM4/COX8C/COX5A 7 hsa00480 Glutathione metabolism 5/350 50/5868 0.175629154007498 0.765981696527524 4259/9446/2878/2876/2879 MGST3/GSTO1/GPX3/GPX1/GPX4 5 hsa03450 Non-homologous end-joining 2/350 13/5868 0.179623825005973 0.765981696527524 5591/10111 PRKDC/RAD50 2 hsa05146 Amoebiasis 9/350 106/5868 0.179984770222314 0.765981696527524 3911/3912/3915/1284/81/2776/3315/5272/1992 LAMA5/LAMB1/LAMC1/COL4A2/ACTN4/GNAQ/HSPB1/SERPINB9/SERPINB1 9 hsa00603 Glycosphingolipid biosynthesis - globo series 2/350 14/5868 0.201749559612615 0.831118166479723 3073/3074 HEXA/HEXB 2 hsa00600 Sphingolipid metabolism 4/350 40/5868 0.213756304802867 0.831118166479723 8613/8560/2720/427 PLPP3/DEGS1/GLB1/ASAH1 4 hsa00052 Galactose metabolism 3/350 27/5868 0.215812550712089 0.831118166479723 2548/2720/7360 GAA/GLB1/UGP2 3 hsa00500 Starch and sucrose metabolism 5/350 54/5868 0.217985059993336 0.831118166479723 2548/178/2990/5836/7360 GAA/AGL/GUSB/PYGL/UGP2 5 hsa04115 p53 signaling pathway 6/350 68/5868 0.217998207601239 0.831118166479723 4616/1021/5366/6477/10912/898 GADD45B/CDK6/PMAIP1/SIAH1/GADD45G/CCNE1 6 hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/350 15/5868 0.224160798823391 0.837171962952665 11041/2530 B4GAT1/FUT8 2 hsa05416 Viral myocarditis 6/350 70/5868 0.237689616806449 0.869943997511604 1605/4628/857/71/1981/1604 DAG1/MYH10/CAV1/ACTG1/EIF4G1/CD55 6 hsa05216 Thyroid cancer 3/350 29/5868 0.248082795629665 0.890179443141741 999/7175/6934 CDH1/TPR/TCF7L2 3 hsa00512 Mucin type O-Glycan biosynthesis 3/350 30/5868 0.264487949351714 0.930201424672377 63917/56913/29071 GALNT11/C1GALT1/C1GALT1C1 3 hsa00360 Phenylalanine metabolism 2/350 17/5868 0.269402598402382 0.930201424672377 4282/9588 MIF/PRDX6 2 hsa05215 Prostate cancer 7/350 89/5868 0.279880935080369 0.938487244834355 1956/7184/3480/64764/6934/4792/898 EGFR/HSP90B1/IGF1R/CREB3L2/TCF7L2/NFKBIA/CCNE1 7 hsa04310 Wnt signaling pathway 11/350 150/5868 0.282059008010325 0.938487244834355 3725/4041/10725/6093/6934/6907/6500/6477/387/1460/27101 JUN/LRP5/NFAT5/ROCK1/TCF7L2/TBL1X/SKP1/SIAH1/RHOA/CSNK2B/CACYBP 11 hsa04540 Gap junction 7/350 90/5868 0.289409693222031 0.943437620280773 1956/2697/153/2776/84790/10376/10383 EGFR/GJA1/ADRB1/GNAQ/TUBA1C/TUBA1B/TUBB4B 7 hsa00640 Propanoate metabolism 3/350 32/5868 0.297641926548693 0.943437620280773 3939/84532/3030 LDHA/ACSS1/HADHA 3 hsa05323 Rheumatoid arthritis 7/350 91/5868 0.299013016263852 0.943437620280773 3725/2353/1514/2321/537/525/533 JUN/FOS/CTSL/FLT1/ATP6AP1/ATP6V1B1/ATP6V0B 7 hsa04722 Neurotrophin signaling pathway 9/350 127/5868 0.3457160325897 0.999999999491113 3725/57498/9500/4792/801/998/387/805/7531 JUN/KIDINS220/MAGED1/NFKBIA/CALM1/CDC42/RHOA/CALM2/YWHAE 9 hsa05214 Glioma 5/350 65/5868 0.346120967816925 0.999999999491113 1956/3480/1021/801/805 EGFR/IGF1R/CDK6/CALM1/CALM2 5 hsa05144 Malaria 4/350 51/5868 0.362363955755491 0.999999999491113 4035/4233/975/3040 LRP1/MET/CD81/HBA2 4 hsa00051 Fructose and mannose metabolism 3/350 36/5868 0.36434049789901 0.999999999491113 226/7167/29085 ALDOA/TPI1/PHPT1 3 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2/350 22/5868 0.38101897906114 0.999999999491113 79586/26229 CHPF/B3GAT3 2 hsa04350 TGF-beta signaling pathway 6/350 84/5868 0.385766867613002 0.999999999491113 4052/655/6093/6500/3397/387 LTBP1/BMP7/ROCK1/SKP1/ID1/RHOA 6 hsa05145 Toxoplasmosis 9/350 132/5868 0.388851677539327 0.999999999491113 3911/3912/3688/3655/3915/3588/3303/3304/4792 LAMA5/LAMB1/ITGB1/ITGA6/LAMC1/IL10RB/HSPA1A/HSPA1B/NFKBIA 9 hsa04514 Cell adhesion molecules (CAMs) 9/350 133/5868 0.397528333106601 0.999999999491113 999/3685/3688/3655/1364/2734/23705/5792/83700 CDH1/ITGAV/ITGB1/ITGA6/CLDN4/GLG1/CADM1/PTPRF/JAM3 9 hsa04912 GnRH signaling pathway 7/350 101/5868 0.397600196135964 0.999999999491113 3725/1956/2776/801/998/805/1081 JUN/EGFR/GNAQ/CALM1/CDC42/CALM2/CGA 7 hsa04972 Pancreatic secretion 7/350 101/5868 0.397600196135964 0.999999999491113 490/493/6548/476/2776/387/8766 ATP2B1/ATP2B4/SLC9A1/ATP1A1/GNAQ/RHOA/RAB11A 7 hsa05211 Renal cell carcinoma 5/350 70/5868 0.406489506065363 0.999999999491113 3725/6513/4233/2034/998 JUN/SLC2A1/MET/EPAS1/CDC42 5 hsa05218 Melanoma 5/350 71/5868 0.41851645626931 0.999999999491113 1956/999/4233/3480/1021 EGFR/CDH1/MET/IGF1R/CDK6 5 hsa00620 Pyruvate metabolism 3/350 40/5868 0.429964902433328 0.999999999491113 3939/84532/5315 LDHA/ACSS1/PKM 3 hsa04010 MAPK signaling pathway 17/350 268/5868 0.432274877962097 0.999999999491113 3725/1956/2353/3727/4616/1843/1848/3303/4763/5921/3304/1852/1649/2768/3315/10912/998 JUN/EGFR/FOS/JUND/GADD45B/DUSP1/DUSP6/HSPA1A/NF1/RASA1/HSPA1B/DUSP9/DDIT3/GNA12/HSPB1/GADD45G/CDC42 17 hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 2/350 25/5868 0.444581034413845 0.999999999491113 8733/80055 GPAA1/PGAP1 2 hsa04971 Gastric acid secretion 5/350 74/5868 0.454315313166248 0.999999999491113 6548/476/2776/801/805 SLC9A1/ATP1A1/GNAQ/CALM1/CALM2 5 hsa04110 Cell cycle 8/350 124/5868 0.46240706529675 0.999999999491113 4616/5591/1021/6500/10912/51529/7531/898 GADD45B/PRKDC/CDK6/SKP1/GADD45G/ANAPC11/YWHAE/CCNE1 8 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2/350 26/5868 0.464960196990632 0.999999999491113 2135/26229 EXTL2/B3GAT3 2 hsa04662 B cell receptor signaling pathway 5/350 75/5868 0.46612264646454 0.999999999491113 3725/2353/10725/975/4792 JUN/FOS/NFAT5/CD81/NFKBIA 5 hsa04660 T cell receptor signaling pathway 7/350 108/5868 0.466989537438203 0.999999999491113 3725/2353/10725/1739/4792/998/387 JUN/FOS/NFAT5/DLG1/NFKBIA/CDC42/RHOA 7 hsa00860 Porphyrin and chlorophyll metabolism 3/350 43/5868 0.47756080492389 0.999999999491113 2495/2990/644 FTH1/GUSB/BLVRA 3 hsa00290 Valine, leucine and isoleucine biosynthesis 1/350 11/5868 0.491900239489786 0.999999999491113 55699 IARS2 1 hsa00310 Lysine degradation 3/350 44/5868 0.493018206268264 0.999999999491113 55870/64324/3030 ASH1L/NSD1/HADHA 3 hsa03050 Proteasome 3/350 44/5868 0.493018206268264 0.999999999491113 5707/51371/5721 PSMD1/POMP/PSME2 3 hsa04114 Oocyte meiosis 7/350 112/5868 0.505853008146259 0.999999999491113 3480/801/6500/51529/805/7531/898 IGF1R/CALM1/SKP1/ANAPC11/CALM2/YWHAE/CCNE1 7 hsa05210 Colorectal cancer 4/350 62/5868 0.510649803670535 0.999999999491113 3725/2353/6934/387 JUN/FOS/TCF7L2/RHOA 4 hsa05012 Parkinson's disease 8/350 130/5868 0.516678690603686 0.999999999491113 1337/4715/7416/7388/341947/7332/9377/7417 COX6A1/NDUFB9/VDAC1/UQCRH/COX8C/UBE2L3/COX5A/VDAC2 8 hsa03020 RNA polymerase 2/350 29/5868 0.523340532937259 0.999999999491113 548644/5430 POLR2J3/POLR2A 2 hsa04744 Phototransduction 2/350 29/5868 0.523340532937259 0.999999999491113 801/805 CALM1/CALM2 2 hsa00190 Oxidative phosphorylation 8/350 132/5868 0.534375935825533 0.999999999491113 1337/537/525/4715/533/7388/341947/9377 COX6A1/ATP6AP1/ATP6V1B1/NDUFB9/ATP6V0B/UQCRH/COX8C/COX5A 8 hsa04330 Notch signaling pathway 3/350 47/5868 0.537968723628657 0.999999999491113 23385/84441/3280 NCSTN/MAML2/HES1 3 hsa00520 Amino sugar and nucleotide sugar metabolism 3/350 48/5868 0.552440824041049 0.999999999491113 3073/3074/7360 HEXA/HEXB/UGP2 3 hsa04120 Ubiquitin mediated proteolysis 8/350 135/5868 0.560453278977117 0.999999999491113 8924/1642/10075/6500/6477/51529/7332/11065 HERC2/DDB1/HUWE1/SKP1/SIAH1/ANAPC11/UBE2L3/UBE2C 8 hsa00040 Pentose and glucuronate interconversions 2/350 32/5868 0.577295219895279 0.999999999491113 2990/7360 GUSB/UGP2 2 hsa05213 Endometrial cancer 3/350 52/5868 0.607549090317344 0.999999999491113 1956/999/6934 EGFR/CDH1/TCF7L2 3 hsa04640 Hematopoietic cell lineage 5/350 88/5868 0.60996766498303 0.999999999491113 1441/3655/7037/4311/1604 CSF3R/ITGA6/TFRC/MME/CD55 5 hsa04020 Calcium signaling pathway 10/350 177/5868 0.617963381518442 0.999999999491113 1956/490/493/153/2776/2065/801/7416/805/7417 EGFR/ATP2B1/ATP2B4/ADRB1/GNAQ/ERBB3/CALM1/VDAC1/CALM2/VDAC2 10 hsa05143 African trypanosomiasis 2/350 35/5868 0.626654927142411 0.999999999491113 2776/3040 GNAQ/HBA2 2 hsa05140 Leishmaniasis 4/350 72/5868 0.630450109684252 0.999999999491113 3725/2353/3688/4792 JUN/FOS/ITGB1/NFKBIA 4 hsa00270 Cysteine and methionine metabolism 2/350 36/5868 0.64208518768614 0.999999999491113 3939/4548 LDHA/MTR 2 hsa00450 Selenocompound metabolism 1/350 17/5868 0.648991712924372 0.999999999491113 4548 MTR 1 hsa00140 Steroid hormone biosynthesis 3/350 56/5868 0.657967319810631 0.999999999491113 1583/3292/1588 CYP11A1/HSD17B1/CYP19A1 3 hsa04340 Hedgehog signaling pathway 3/350 56/5868 0.657967319810631 0.999999999491113 4036/655/2737 LRP2/BMP7/GLI3 3 hsa04666 Fc gamma R-mediated phagocytosis 5/350 94/5868 0.668288544507848 0.999999999491113 8613/10163/1072/998/10094 PLPP3/WASF2/CFL1/CDC42/ARPC3 5 hsa00670 One carbon pool by folate 1/350 18/5868 0.669988619517513 0.999999999491113 4548 MTR 1 hsa00100 Steroid biosynthesis 1/350 19/5868 0.689732890144671 0.999999999491113 1718 DHCR24 1 hsa00590 Arachidonic acid metabolism 3/350 59/5868 0.692615333718259 0.999999999491113 2878/2876/1573 GPX3/GPX1/CYP2J2 3 hsa04270 Vascular smooth muscle contraction 6/350 116/5868 0.69901853437685 0.999999999491113 6093/2776/2768/801/387/805 ROCK1/GNAQ/GNA12/CALM1/RHOA/CALM2 6 hsa00350 Tyrosine metabolism 2/350 41/5868 0.711766584436785 0.999999999491113 4282/51451 MIF/LCMT1 2 hsa05219 Bladder cancer 2/350 42/5868 0.724260475872178 0.999999999491113 1956/999 EGFR/CDH1 2 hsa01040 Biosynthesis of unsaturated fatty acids 1/350 21/5868 0.725757215319427 0.999999999491113 3030 HADHA 1 hsa04916 Melanogenesis 5/350 101/5868 0.728741062095589 0.999999999491113 64764/6934/2776/801/805 CREB3L2/TCF7L2/GNAQ/CALM1/CALM2 5 hsa00071 Fatty acid degradation 2/350 43/5868 0.736294606162339 0.999999999491113 37/3030 ACADVL/HADHA 2 hsa00410 beta-Alanine metabolism 1/350 22/5868 0.742173321807917 0.999999999491113 3030 HADHA 1 hsa04710 Circadian rhythm 1/350 22/5868 0.742173321807917 0.999999999491113 6500 SKP1 1 hsa05142 Chagas disease (American trypanosomiasis) 5/350 104/5868 0.752088239717806 0.999999999491113 3725/2353/811/2776/4792 JUN/FOS/CALR/GNAQ/NFKBIA 5 hsa04964 Proximal tubule bicarbonate reclamation 1/350 23/5868 0.757609404149215 0.999999999491113 476 ATP1A1 1 hsa04320 Dorso-ventral axis formation 1/350 24/5868 0.772123811086388 0.999999999491113 1956 EGFR 1 hsa04380 Osteoclast differentiation 6/350 128/5868 0.784400496648522 0.999999999491113 3725/2353/3727/2354/3726/4792 JUN/FOS/JUND/FOSB/JUNB/NFKBIA 6 hsa04950 Maturity onset diabetes of the young 1/350 25/5868 0.785771426781077 0.999999999491113 3280 HES1 1 hsa04610 Complement and coagulation cascades 3/350 69/5868 0.788972556038136 0.999999999491113 2153/4179/1604 F5/CD46/CD55 3 hsa04720 Long-term potentiation 3/350 70/5868 0.797074559058767 0.999999999491113 2776/801/805 GNAQ/CALM1/CALM2 3 hsa04730 Long-term depression 3/350 70/5868 0.797074559058767 0.999999999491113 3480/2776/2768 IGF1R/GNAQ/GNA12 3 hsa05212 Pancreatic cancer 3/350 70/5868 0.797074559058767 0.999999999491113 1956/1021/998 EGFR/CDK6/CDC42 3 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/350 26/5868 0.798603875972695 0.999999999491113 11041 B4GAT1 1 hsa03018 RNA degradation 3/350 71/5868 0.804915704313171 0.999999999491113 2023/694/170506 ENO1/BTG1/DHX36 3 hsa04976 Bile secretion 3/350 71/5868 0.804915704313171 0.999999999491113 6513/6548/476 SLC2A1/SLC9A1/ATP1A1 3 hsa00030 Pentose phosphate pathway 1/350 27/5868 0.810669717021918 0.999999999491113 226 ALDOA 1 hsa04966 Collecting duct acid secretion 1/350 27/5868 0.810669717021918 0.999999999491113 525 ATP6V1B1 1 hsa03440 Homologous recombination 1/350 28/5868 0.82201462355202 0.999999999491113 10111 RAD50 1 hsa04150 mTOR signaling pathway 2/350 52/5868 0.825701257680452 0.999999999491113 6194/1975 RPS6/EIF4B 2 hsa00340 Histidine metabolism 1/350 29/5868 0.83268155535969 0.999999999491113 51451 LCMT1 1 hsa04370 VEGF signaling pathway 3/350 76/5868 0.840393728564298 0.999999999491113 10725/3315/998 NFAT5/HSPB1/CDC42 3 hsa05223 Non-small cell lung cancer 2/350 54/5868 0.841451534655257 0.999999999491113 1956/1021 EGFR/CDK6 2 hsa00591 Linoleic acid metabolism 1/350 30/5868 0.842710919227494 0.999999999491113 1573 CYP2J2 1 hsa00650 Butanoate metabolism 1/350 30/5868 0.842710919227494 0.999999999491113 3030 HADHA 1 hsa05217 Basal cell carcinoma 2/350 55/5868 0.848834109025764 0.999999999491113 2737/6934 GLI3/TCF7L2 2 hsa04070 Phosphatidylinositol signaling system 3/350 78/5868 0.852947960603149 0.999999999491113 1040/801/805 CDS1/CALM1/CALM2 3 hsa04623 Cytosolic DNA-sensing pathway 2/350 56/5868 0.855903249367065 0.999999999491113 4792/103 NFKBIA/ADAR 2 hsa00260 Glycine, serine and threonine metabolism 1/350 32/5868 0.861006704114903 0.999999999491113 2731 GLDC 1 hsa00562 Inositol phosphate metabolism 2/350 57/5868 0.862669950981883 0.999999999491113 7167/51477 TPI1/ISYNA1 2 hsa00564 Glycerophospholipid metabolism 3/350 80/5868 0.864634241642122 0.999999999491113 8613/23761/1040 PLPP3/PISD/CDS1 3 hsa04621 NOD-like receptor signaling pathway 2/350 58/5868 0.869145016690207 0.999999999491113 7184/4792 HSP90B1/NFKBIA 2 hsa03410 Base excision repair 1/350 33/5868 0.869342491222474 0.999999999491113 142 PARP1 1 hsa03015 mRNA surveillance pathway 3/350 83/5868 0.880635088680526 0.999999999491113 5411/8106/26019 PNN/PABPN1/UPF2 3 hsa00565 Ether lipid metabolism 1/350 36/5868 0.891475589453249 0.999999999491113 8613 PLPP3 1 hsa03022 Basal transcription factors 1/350 36/5868 0.891475589453249 0.999999999491113 2969 GTF2I 1 hsa04130 SNARE interactions in vesicular transport 1/350 36/5868 0.891475589453249 0.999999999491113 6844 VAMP2 1 hsa04012 ErbB signaling pathway 3/350 87/5868 0.89934977631352 0.999999999491113 3725/1956/2065 JUN/EGFR/ERBB3 3 hsa05160 Hepatitis C 5/350 134/5868 0.909405370194184 0.999999999491113 1956/1364/975/440275/4792 EGFR/CLDN4/CD81/EIF2AK4/NFKBIA 5 hsa04920 Adipocytokine signaling pathway 2/350 68/5868 0.920069321805873 0.999999999491113 6513/4792 SLC2A1/NFKBIA 2 hsa04910 Insulin signaling pathway 5/350 138/5868 0.921786530694823 0.999999999491113 6194/5792/801/5836/805 RPS6/PTPRF/CALM1/PYGL/CALM2 5 hsa00380 Tryptophan metabolism 1/350 42/5868 0.925151143695887 0.999999999491113 3030 HADHA 1 hsa04960 Aldosterone-regulated sodium reabsorption 1/350 42/5868 0.925151143695887 0.999999999491113 476 ATP1A1 1 hsa00980 Metabolism of xenobiotics by cytochrome P450 2/350 71/5868 0.931274656345136 0.999999999491113 4259/9446 MGST3/GSTO1 2 hsa00280 Valine, leucine and isoleucine degradation 1/350 44/5868 0.933874903069142 0.999999999491113 3030 HADHA 1 hsa03420 Nucleotide excision repair 1/350 44/5868 0.933874903069142 0.999999999491113 1642 DDB1 1 hsa04973 Carbohydrate digestion and absorption 1/350 44/5868 0.933874903069142 0.999999999491113 476 ATP1A1 1 hsa00982 Drug metabolism - cytochrome P450 2/350 73/5868 0.93790288720207 0.999999999491113 4259/9446 MGST3/GSTO1 2 hsa05220 Chronic myeloid leukemia 2/350 73/5868 0.93790288720207 0.999999999491113 1021/4792 CDK6/NFKBIA 2 hsa00240 Pyrimidine metabolism 3/350 99/5868 0.940692300367484 0.999999999491113 548644/5430/4832 POLR2J3/POLR2A/NME3 3 hsa00514 Other types of O-glycan biosynthesis 1/350 46/5868 0.94158445855398 0.999999999491113 283464 GXYLT1 1 hsa04975 Fat digestion and absorption 1/350 46/5868 0.94158445855398 0.999999999491113 8613 PLPP3 1 hsa04620 Toll-like receptor signaling pathway 3/350 102/5868 0.948228050633551 0.999999999491113 3725/2353/4792 JUN/FOS/NFKBIA 3 hsa04930 Type II diabetes mellitus 1/350 48/5868 0.948397420741388 0.999999999491113 5315 PKM 1 hsa03008 Ribosome biogenesis in eukaryotes 2/350 79/5868 0.954340030520088 0.999999999491113 5901/1460 RAN/CSNK2B 2 hsa04146 Peroxisome 2/350 79/5868 0.954340030520088 0.999999999491113 11001/54677 SLC27A2/CROT 2 hsa00561 Glycerolipid metabolism 1/350 50/5868 0.954417796316296 0.999999999491113 8613 PLPP3 1 hsa04630 Jak-STAT signaling pathway 5/350 155/5868 0.959263671597655 0.999999999491113 1441/3572/1442/5618/3588 CSF3R/IL6ST/CSH1/PRLR/IL10RB 5 hsa00983 Drug metabolism - other enzymes 1/350 52/5868 0.959737557600838 0.999999999491113 2990 GUSB 1 hsa05320 Autoimmune thyroid disease 1/350 52/5868 0.959737557600838 0.999999999491113 1081 CGA 1 hsa05014 Amyotrophic lateral sclerosis (ALS) 1/350 53/5868 0.962160503756221 0.999999999491113 2876 GPX1 1 hsa04914 Progesterone-mediated oocyte maturation 2/350 86/5868 0.968279718896235 0.999999999491113 3480/51529 IGF1R/ANAPC11 2 hsa05221 Acute myeloid leukemia 1/350 57/5868 0.970482578004999 0.999999999491113 6934 TCF7L2 1 hsa00970 Aminoacyl-tRNA biosynthesis 1/350 63/5868 0.979670142476987 0.999999999491113 55699 IARS2 1 hsa03320 PPAR signaling pathway 1/350 70/5868 0.986848321918579 0.999999999491113 11001 SLC27A2 1 hsa04622 RIG-I-like receptor signaling pathway 1/350 71/5868 0.987642231426771 0.999999999491113 4792 NFKBIA 1 hsa00230 Purine metabolism 4/350 162/5868 0.989416660847179 0.999999999491113 548644/5430/4832/5315 POLR2J3/POLR2A/NME3/PKM 4 hsa04060 Cytokine-cytokine receptor interaction 8/350 265/5868 0.991624660901974 0.999999999491113 1956/1441/4233/3572/2321/655/5618/3588 EGFR/CSF3R/MET/IL6ST/FLT1/BMP7/PRLR/IL10RB 8 hsa04210 Apoptosis 1/350 87/5868 0.995443550823447 0.999999999491113 4792 NFKBIA 1 hsa04062 Chemokine signaling pathway 4/350 189/5868 0.997052739432379 0.999999999491113 6093/4792/998/387 ROCK1/NFKBIA/CDC42/RHOA 4 hsa05322 Systemic lupus erythematosus 2/350 136/5868 0.997925196460609 0.999999999491113 81/6741 ACTN4/SSB 2 hsa04650 Natural killer cell mediated cytotoxicity 1/350 136/5868 0.999789202811231 0.999999999491113 10725 NFAT5 1 hsa04080 Neuroactive ligand-receptor interaction 5/350 272/5868 0.999802075905178 0.999999999491113 1442/2564/5618/153/1081 CSH1/GABRE/PRLR/ADRB1/CGA 5 hsa04740 Olfactory transduction 2/350 388/5868 0.999999999491113 0.999999999491113 801/805 CALM1/CALM2 2