ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	56/749	332/18367	8.56393870957526e-20	7.4078069837826e-17	EGFR/AHNAK/CD46/HSPA5/CDH1/RPL23A/ITGB1/ITGA6/LDHA/KTN1/ALDOA/RPL6/RPL14/MACF1/PLEC/BSG/RPL24/IQGAP1/SLC3A2/RPL15/RPS26/ARGLU1/S100P/PKN2/ANK3/RPS2/RTN4/SPTAN1/PFN1/SPTBN1/HSPA1A/ANXA1/ENO1/KIF5B/CTNND1/DLG1/WASF2/ERC1/LARP1/LRRFIP1/FMNL2/KRT18/TRIM29/PKM/PRDX6/DNAJB1/RAN/TLN1/TAGLN2/EFHD2/EPS8L1/YWHAE/EIF4H/CNN3/CAPZB/RANBP1	56
GO:0003735	structural constituent of ribosome	35/749	182/18367	1.35026975861319e-14	5.83991670600204e-12	RPS21/RPLP0/RPS20/RPL13A/RPL23A/RPS3A/RPS13/RPS11/RPL27A/RPS10/RPS6/RPS16/RPL31/RPL6/RPL14/RPL7/RPL21/RPS25/RPL24/RPL19/RPL13/RPL18A/RPL9/RPL15/RPS26/UBA52/RPL26/RPL23/RPS2/RPL4/RPL3/RPL17/RPS17/RPS4Y1/MRPS6	35
GO:0001618	virus receptor activity	17/749	76/18367	7.97898807800902e-09	2.13132894856622e-06	EGFR/CD46/ITGAV/ITGB1/DAG1/BSG/TFRC/SLC1A5/SLC52A1/DPP4/HSPA1A/CD81/ITGB5/HSPA1B/CD55/LAMP1/SLC52A2	17
GO:0140272	exogenous protein binding	17/749	77/18367	9.85585640955477e-09	2.13132894856622e-06	EGFR/CD46/ITGAV/ITGB1/DAG1/BSG/TFRC/SLC1A5/SLC52A1/DPP4/HSPA1A/CD81/ITGB5/HSPA1B/CD55/LAMP1/SLC52A2	17
GO:0005178	integrin binding	22/749	144/18367	9.03128849373256e-08	1.56241290941573e-05	EGFR/FBN1/FBLN1/ITGB4/LAMA5/ITGAV/LAMB1/ITGB1/P4HB/UTRN/PLPP3/DST/JAM3/FERMT1/CALR/CD81/ITGB5/ACTN4/PPIA/TSPAN4/TLN1/IGF2	22
GO:0019838	growth factor binding	20/749	141/18367	1.16276099002634e-06	0.000167631376062131	LRP2/EGFR/ITGB4/NRP2/ITGAV/ITGA6/GLG1/CRIM1/DUSP1/TGFBR3/IL6ST/LTBP1/FLT1/RPS2/IGF1R/NRP1/GPC1/LTBP3/ERBB3/SDCBP	20
GO:0045182	translation regulator activity	19/749	140/18367	4.18229619335897e-06	0.000516812315322216	EEF1A1/EIF3A/EEF1B2/EIF4G1/PURA/EIF3H/EIF2AK4/CELF1/LARP1/CIRBP/TUFM/EIF1/IGF2BP3/EIF2S2/EIF3F/EIF4H/EIF3I/EIF5A/EIF4B	19
GO:0090079	translation regulator activity, nucleic acid binding	16/749	108/18367	7.63639049262176e-06	0.000744390877379762	EEF1A1/EIF3A/EEF1B2/EIF4G1/PURA/EIF3H/CELF1/LARP1/TUFM/EIF1/EIF2S2/EIF3F/EIF4H/EIF3I/EIF5A/EIF4B	16
GO:0044325	transmembrane transporter binding	18/749	133/18367	7.74510739470273e-06	0.000744390877379762	AKAP9/TCAF1/CAV1/ANK3/DLG1/DIAPH1/ACTN4/SLC5A3/PPP1R9A/VAMP2/PRKCSH/CALM1/VDAC1/USP10/S100A10/PHPT1/CALM2/YWHAE	18
GO:0003779	actin binding	38/749	440/18367	1.16479376518276e-05	0.00100754660688309	EGFR/ITGB1/DAG1/SYNE2/P4HB/ALDOA/IQGAP2/MACF1/PLEC/UTRN/MYH10/IQGAP1/SLC6A4/SPTAN1/DST/FERMT1/PFN1/TMSB4X/SPTBN1/DIAPH1/ACTN4/WASF2/TRIOBP/PPP1R9A/CFL1/MSRB2/PHACTR2/FMNL2/RAI14/TLN1/TPM4/ARPC3/DSTN/PDLIM2/EPS8L1/CNN3/CAPZB/COTL1	38
GO:0098631	cell adhesion mediator activity	11/749	59/18367	2.25329536268964e-05	0.00177190953520595	ITGB1/BCAM/BSG/DSP/DSG2/DSC2/JAM3/ANXA1/KRT18/TRIM29/CNN3	11
GO:0008135	translation factor activity, RNA binding	13/749	84/18367	3.35457719909751e-05	0.00241809106434946	EEF1A1/EIF3A/EEF1B2/EIF4G1/EIF3H/TUFM/EIF1/EIF2S2/EIF3F/EIF4H/EIF3I/EIF5A/EIF4B	13
GO:0051082	unfolded protein binding	16/749	122/18367	3.63541597675638e-05	0.00241894986145713	HSP90B1/HSPA5/LMAN1/NACA/SIL1/SERPINH1/NPM1/CALR/HSPA1A/CANX/HSPA1B/PPIA/DNAJB1/PTGES3/TUBB4B/CCT3	16
GO:0048306	calcium-dependent protein binding	13/749	88/18367	5.54108808956244e-05	0.0034236008553368	S100P/ATP2B4/ANXA1/SLC9A1/S100A9/VAMP2/CALM1/DDX5/CLN3/S100A10/ANXA4/ANXA3/CALM2	13
GO:0051020	GTPase binding	27/749	291/18367	6.35237539531316e-05	0.0035513084886394	GOLGA4/IQGAP2/MYCBP2/CAV1/IQGAP1/TRIP11/PKN2/ATP6AP1/GCC2/PFN1/SPTBN1/ENO1/AKAP13/RANBP2/YBX1/DIAPH1/RASA1/ROCK1/TRIOBP/PPP1R9A/RABGAP1/ERC1/FMNL2/KPNB1/RHOBTB3/CLTA/RANBP1	27
GO:0140678	molecular function inhibitor activity	16/749	128/18367	6.5688943142463e-05	0.0035513084886394	RPS20/CAV1/RPL23/DYNLL1/ANXA5/ANXA1/RASA1/FAF2/PURA/DDIT3/CALM1/ID1/ANXA4/PHPT1/ANXA3/CALM2	16
GO:0048027	mRNA 5'-UTR binding	7/749	27/18367	7.9211443699013e-05	0.00369952055722827	RPS3A/RPS13/MYH10/RPL26/DHX36/LARP1/IGF2BP3	7
GO:0097718	disordered domain specific binding	8/749	36/18367	8.07613915694259e-05	0.00369952055722827	GAPDH/GJA1/GJA5/HSPA1A/NCOA3/CALM1/CLTC/CALM2	8
GO:0051015	actin filament binding	22/749	217/18367	8.20237120807355e-05	0.00369952055722827	EGFR/SYNE2/IQGAP2/MACF1/UTRN/MYH10/IQGAP1/SLC6A4/SPTAN1/FERMT1/SPTBN1/ACTN4/TRIOBP/PPP1R9A/CFL1/FMNL2/TLN1/TPM4/ARPC3/DSTN/CAPZB/COTL1	22
GO:0019843	rRNA binding	11/749	68/18367	8.84392115393939e-05	0.00369952055722827	RPLP0/RPL23A/RPS13/RPS11/RPL19/RPL9/RPL23/NPM1/CIRBP/RPS4Y1/MRPS6	11
GO:0031625	ubiquitin protein ligase binding	27/749	297/18367	8.98149499442701e-05	0.00369952055722827	JUN/EGFR/HSPA5/UBA52/RPL23/RTN4/CALR/TPI1/HSPA1A/HERC2/ACTG1/HSPA1B/TRIOBP/FAF2/ATF6/ERBB3/POLR2A/PSMD1/NFKBIA/PCBP2/PRDX6/HM13/NEK6/TUBA1B/UBE2L3/YWHAE/CACYBP	27
GO:0044389	ubiquitin-like protein ligase binding	28/749	316/18367	0.000104314275521845	0.00400377132805676	JUN/EGFR/HSPA5/UBA52/RPL23/RTN4/CALR/TPI1/HSPA1A/HERC2/ACTG1/HSPA1B/TRIOBP/FAF2/ATF6/ERBB3/POLR2A/PSMD1/NFKBIA/PCBP2/PRDX6/HM13/NEK6/TUBA1B/UBE2L3/YWHAE/UBE2C/CACYBP	28
GO:0031994	insulin-like growth factor I binding	5/749	13/18367	0.000108966854197028	0.00400377132805676	LRP2/ITGB4/ITGAV/ITGA6/IGF1R	5
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	13/749	94/18367	0.000111087296963424	0.00400377132805676	GANAB/GAA/HEXA/AGL/NAGLU/FUCA1/MANBA/GUSB/MAN2A1/MAN1A2/GLB1/MOGS/HEXB	13
GO:0098632	cell-cell adhesion mediator activity	9/749	49/18367	0.00014100963130714	0.00487893324322703	BSG/DSP/DSG2/DSC2/JAM3/ANXA1/KRT18/TRIM29/CNN3	9
GO:0047485	protein N-terminus binding	14/749	110/18367	0.000152311473181683	0.00506728555008291	RPS21/SRRM2/NPM1/HSPA1A/NIPBL/HSPA1B/NCOA3/CALM1/ID1/PARP1/CALM2/EIF5A/SDCBP/BANF1	14
GO:0044183	protein folding chaperone	8/749	40/18367	0.000177700678672713	0.00559828375006004	HSPA5/CCDC47/CALR/HSPA1A/HSPA1B/HSPB1/DNAJB1/CCT3	8
GO:0016209	antioxidant activity	12/749	86/18367	0.000185560295336333	0.00559828375006004	MGST3/SOD3/GSTO1/GPX3/S100A9/GPX8/TXN/PRDX6/GPX1/PRDX4/GPX4/HBA2	12
GO:0004602	glutathione peroxidase activity	6/749	22/18367	0.000191943393369498	0.00559828375006004	MGST3/GPX3/GPX8/PRDX6/GPX1/GPX4	6
GO:0003743	translation initiation factor activity	9/749	51/18367	0.000194160130059886	0.00559828375006004	EIF3A/EIF4G1/EIF3H/EIF1/EIF2S2/EIF3F/EIF4H/EIF3I/EIF4B	9
GO:0008509	anion transmembrane transporter activity	27/749	314/18367	0.000224881636026898	0.00627492306978279	SLC26A2/SLC2A1/CLDN4/SLC22A11/SLC12A9/SLC3A2/SLC38A1/SLC38A2/GJA1/SLC1A5/SLC19A1/SLC52A1/SLC6A4/SLC13A4/GABRE/SLC38A9/CLIC3/SLC9A1/SLC16A12/SLC52A3/SERINC3/SLC35B4/SLC52A2/SLC16A1/VDAC1/FXYD3/VDAC2	27
GO:0016922	nuclear receptor binding	16/749	144/18367	0.000264699422272919	0.00715515625831485	JUND/FUS/TACC2/ISL1/CALR/ARID1A/ACTN4/NCOR1/TCF7L2/NCOA3/FOXP1/NSD1/DDX5/PARP1/HMGN3/HMGA1	16
GO:0043021	ribonucleoprotein complex binding	16/749	149/18367	0.000390153308343669	0.0102267458096143	NEAT1/HSPA5/RPN2/NPM1/CCDC47/NEMF/SEC61A1/LARP1/DDX5/SNRPD2/EIF1/CSNK2B/EIF4H/SNRPC/EIF5A/EIF4B	16
GO:0050840	extracellular matrix binding	9/749	56/18367	0.000403208879764593	0.0102581082645992	ADGRG1/ITGAV/ITGB1/DAG1/ITGA6/BCAM/TINAGL1/GPC1/SMOC1	9
GO:0043024	ribosomal small subunit binding	5/749	17/18367	0.000457260404993799	0.0110949734988336	NPM1/LARP1/EIF1/EIF4H/EIF4B	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	9/749	57/18367	0.000461756122494809	0.0110949734988336	P4HB/PDIA3/PDIA4/GSTO1/PCYOX1/PDIA6/MSRB2/TXN/TXNL1	9
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	25/749	299/18367	0.000573209121074282	0.0134006997224123	JUN/FOS/JUND/FUS/TACC2/NPM1/ISL1/CALR/ARID1A/ACTN4/NCOR1/TCF7L2/NCOA3/GTF2I/FOXP1/NSD1/NFKBIA/CITED2/DDX5/HSPB1/PARP1/HES1/HMGN3/ANXA4/HMGA1	25
GO:0055102	lipase inhibitor activity	5/749	18/18367	0.000612006453691909	0.0139311995379869	ANXA5/ANXA1/FAF2/ANXA4/ANXA3	5
GO:0097493	structural molecule activity conferring elasticity	4/749	11/18367	0.000719545221692088	0.0159591440195809	FBN2/AHNAK/FBN1/LAMC1	4
GO:0015175	neutral amino acid transmembrane transporter activity	7/749	38/18367	0.000762052055871886	0.0164793757082295	SLC3A2/SLC38A1/SLC43A2/SLC38A2/SLC1A5/SLC38A9/SERINC3	7
GO:0043236	laminin binding	6/749	28/18367	0.000786519494541852	0.0165936429946025	ITGB1/DAG1/ITGA6/BCAM/TINAGL1/GPC1	6
GO:0003725	double-stranded RNA binding	10/749	74/18367	0.000812014566226502	0.0167236333282363	TFRC/SLC3A2/DHX36/LRRFIP1/ADAR/CLTC/TUBA1B/TUBB4B/EIF4H/EIF4B	10
GO:0003712	transcription coregulator activity	35/749	489/18367	0.000944881170793125	0.0186438809258002	N4BP2L2/SF1/FUS/TRIP11/TLE4/NPM1/BRD4/CCAR1/KMT2C/HSPA1A/BTG1/MAGED1/KDM5A/VGLL1/RERE/ARID1A/ACTN4/MAML2/DDX17/NCOR1/NCOA3/PTPN14/NSD1/ARID5B/RSF1/KDM5B/BRD7/SMARCA2/CITED2/USP22/TBL1X/DNAJB1/SIAH2/UBE2L3/HMGA1	35
GO:0005520	insulin-like growth factor binding	6/749	29/18367	0.000957874306421507	0.0186438809258002	LRP2/ITGB4/ITGAV/ITGA6/CRIM1/IGF1R	6
GO:0005200	structural constituent of cytoskeleton	12/749	103/18367	0.000988808366518463	0.0186438809258002	KRT19/PLEC/DSP/ANK3/SPTAN1/SPTBN1/ACTG1/TLN1/ARPC3/TUBA1C/TUBA1B/TUBB4B	12
GO:0004601	peroxidase activity	8/749	51/18367	0.000991466500100356	0.0186438809258002	MGST3/GPX3/GPX8/PRDX6/GPX1/PRDX4/GPX4/HBA2	8
GO:0003713	transcription coactivator activity	22/749	262/18367	0.00113186597558035	0.0208311504016383	FUS/TRIP11/NPM1/BRD4/CCAR1/KMT2C/MAGED1/KDM5A/VGLL1/RERE/ARID1A/ACTN4/MAML2/DDX17/NCOA3/ARID5B/BRD7/SMARCA2/CITED2/USP22/UBE2L3/HMGA1	22
GO:0061134	peptidase regulator activity	20/749	230/18367	0.00122368930393881	0.022051900998064	ITIH5/GAPDH/APLP2/SPINT1/FBLN1/APP/CRIM1/CTSC/SPINT2/SERPINF1/CAV1/SERPINH1/ROCK1/CST3/TIMP3/PCOLCE2/TFPI2/SERPINB9/SERPINB1/PSME2	20
GO:0008201	heparin binding	16/749	166/18367	0.00126747528236197	0.0223748187600633	FBN1/APLP2/NRP2/ADGRG1/APP/LRPAP1/CCDC80/TGFBR3/SOD3/ADAMTS1/NRP1/BMP7/PTPRF/FSTL1/SMOC1/PCOLCE2	16
GO:0090482	vitamin transmembrane transporter activity	6/749	31/18367	0.00138527663532965	0.0238360504092503	SLC2A1/SLC19A1/SLC52A1/SLC19A3/SLC52A3/SLC52A2	6
GO:0015036	disulfide oxidoreductase activity	7/749	42/18367	0.00141457180610659	0.0238360504092503	P4HB/PDIA3/PDIA4/GSTO1/PDIA6/TXN/TXNL1	7
GO:0004859	phospholipase inhibitor activity	4/749	13/18367	0.00146047476495984	0.0238360504092503	ANXA5/ANXA1/ANXA4/ANXA3	4
GO:0072542	protein phosphatase activator activity	4/749	13/18367	0.00146047476495984	0.0238360504092503	PPP1R15A/B3GAT3/CALM1/CALM2	4
GO:0008514	organic anion transmembrane transporter activity	17/749	185/18367	0.00153306882775316	0.0245574914075274	SLC26A2/SLC2A1/SLC22A11/SLC3A2/SLC38A1/SLC38A2/GJA1/SLC1A5/SLC19A1/SLC52A1/SLC38A9/SLC16A12/SLC52A3/SERINC3/SLC35B4/SLC52A2/SLC16A1	17
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	8/749	55/18367	0.0016432997549907	0.0254878630548363	MGST3/GPX3/GPX8/PRDX6/GPX1/PRDX4/GPX4/HBA2	8
GO:0140297	DNA-binding transcription factor binding	29/749	394/18367	0.00165008130759634	0.0254878630548363	JUN/FOS/JUND/FUS/TLE4/TACC2/NPM1/ISL1/CALR/ARID1A/ACTN4/NCOR1/TCF7L2/PURA/NCOA3/GTF2I/FOXP1/NSD1/DDIT3/NFKBIA/CITED2/DDX5/HSPB1/PARP1/HES1/HMGN3/NEK6/ANXA4/HMGA1	29
GO:0015926	glucosidase activity	4/749	14/18367	0.00197913451870557	0.0300342343628126	GANAB/GAA/AGL/MOGS	4
GO:0017134	fibroblast growth factor binding	5/749	23/18367	0.0020295702933925	0.0302685914445606	ITGAV/GLG1/TGFBR3/RPS2/GPC1	5
GO:0004867	serine-type endopeptidase inhibitor activity	11/749	98/18367	0.00214319849675542	0.0314214694863295	ITIH5/APLP2/SPINT1/APP/CRIM1/SPINT2/SERPINF1/SERPINH1/TFPI2/SERPINB9/SERPINB1	11
GO:0031267	small GTPase binding	21/749	259/18367	0.00222590893327011	0.0320901871213108	GOLGA4/IQGAP2/MYCBP2/CAV1/IQGAP1/TRIP11/PKN2/ATP6AP1/GCC2/PFN1/AKAP13/RANBP2/DIAPH1/ROCK1/TRIOBP/RABGAP1/ERC1/FMNL2/KPNB1/RHOBTB3/RANBP1	21
GO:0035198	miRNA binding	6/749	34/18367	0.00228100570896704	0.0321553153041815	NEAT1/KCNQ1OT1/SOX4/YBX1/PUM1/HNRNPA1	6
GO:0048029	monosaccharide binding	9/749	71/18367	0.00230477404492399	0.0321553153041815	LMAN1/ALDOA/BSG/COLEC12/MANBA/P3H1/LMAN2/PYGL/UGP2	9
GO:0050998	nitric-oxide synthase binding	4/749	15/18367	0.00261245110908398	0.0358693684025023	CAV1/SLC6A4/ATP2B4/CALM1	4
GO:0005539	glycosaminoglycan binding	19/749	230/18367	0.00286821112602579	0.0387656660001923	FBN1/APLP2/NRP2/ADGRG1/APP/LRPAP1/CCDC80/EXTL2/TGFBR3/SOD3/ADAMTS1/NRP1/BMP7/PTPRF/FSTL1/GNS/SMOC1/PPIA/PCOLCE2	19
GO:0008238	exopeptidase activity	11/749	103/18367	0.00317780723998949	0.0422892809629371	CTSC/ENPEP/TFRC/CTSV/DPP4/MMP15/CTSA/MME/CPD/CPVL/CPQ	11
GO:0030246	carbohydrate binding	21/749	271/18367	0.00379981168107388	0.0498005621837713	LMAN1/GANAB/GAA/ALDOA/BSG/GALNT11/AGL/COLEC12/MLEC/MANBA/CALR/CRYBG3/OS9/CANX/GUSB/P3H1/MAN2A1/LMAN2/CHID1/PYGL/UGP2	21
GO:0016860	intramolecular oxidoreductase activity	7/749	51/18367	0.00442510027943415	0.0571300259956797	P4HB/PDIA3/MIF/PDIA4/TPI1/PDIA6/PTGES3	7
GO:0008022	protein C-terminus binding	16/749	189/18367	0.00469401059473373	0.0597105759477158	FBLN1/BCAM/PRRC2C/DST/DLG1/NIPBL/PPP1R9A/VAMP2/RABAC1/POLR2A/TBL1X/ID1/SIAH1/DYNLT1/SDCBP/BANF1	16
GO:0046332	SMAD binding	9/749	79/18367	0.00477798965843667	0.059897986297793	JUN/FOS/TGFBR3/PURA/USP9X/CITED2/DDX5/PARP1/YY1	9
GO:0001968	fibronectin binding	5/749	28/18367	0.00501027741801088	0.0619127138082773	FBLN1/CTSL/ITGAV/ITGB1/CCDC80	5
GO:0098641	cadherin binding involved in cell-cell adhesion	4/749	18/18367	0.00531358606749282	0.0647359429349478	ANXA1/KRT18/TRIM29/CNN3	4
GO:0019199	transmembrane receptor protein kinase activity	13/749	143/18367	0.00573222987422597	0.0680758132980337	EGFR/NRP2/EFEMP1/CRIM1/MET/TGFBR3/EPHB4/LTBP1/FLT1/IGF1R/NRP1/ERBB3/BAZ1B	13
GO:0097110	scaffold protein binding	8/749	67/18367	0.00574512644018088	0.0680758132980337	PSAP/IL6ST/DSP/DYNLL1/KRT8/ATP2B4/KRT18/YWHAE	8
GO:0061135	endopeptidase regulator activity	16/749	194/18367	0.00601930734592948	0.0700460387693719	ITIH5/GAPDH/APLP2/SPINT1/APP/CRIM1/SPINT2/SERPINF1/SERPINH1/ROCK1/CST3/TIMP3/TFPI2/SERPINB9/SERPINB1/PSME2	16
GO:0016798	hydrolase activity, acting on glycosyl bonds	13/749	144/18367	0.00607335596266231	0.0700460387693719	GANAB/GAA/HEXA/AGL/NAGLU/FUCA1/MANBA/GUSB/MAN2A1/MAN1A2/GLB1/MOGS/HEXB	13
GO:1901681	sulfur compound binding	20/749	265/18367	0.00622174658426295	0.0708132999393086	FBN1/APLP2/NRP2/LRP1/ADGRG1/APP/LRPAP1/CCDC80/TGFBR3/SOD3/ADAMTS1/NRP1/BMP7/PTPRF/FSTL1/SMOC1/ACADVL/PPIA/HADHA/PCOLCE2	20
GO:0003746	translation elongation factor activity	4/749	19/18367	0.006516436105044	0.0715752844160117	EEF1A1/EEF1B2/TUFM/EIF5A	4
GO:0008330	protein tyrosine/threonine phosphatase activity	3/749	10/18367	0.00653693349001725	0.0715752844160117	DUSP1/DUSP6/DUSP9	3
GO:0070008	serine-type exopeptidase activity	3/749	10/18367	0.00653693349001725	0.0715752844160117	CTSA/CPD/CPVL	3
GO:0046966	thyroid hormone receptor binding	5/749	30/18367	0.00679412590954119	0.0734614863969141	FUS/NCOR1/NCOA3/NSD1/HMGN3	5
GO:0004866	endopeptidase inhibitor activity	15/749	180/18367	0.006999405293141	0.0747467355378638	ITIH5/GAPDH/APLP2/SPINT1/APP/CRIM1/SPINT2/SERPINF1/SERPINH1/ROCK1/CST3/TIMP3/TFPI2/SERPINB9/SERPINB1	15
GO:0030165	PDZ domain binding	9/749	84/18367	0.00714545106828407	0.0753757948056795	ATP2B1/CRIM1/CADM1/TGFBR3/GJA1/ATP2B4/KIDINS220/ADRB1/ERC1	9
GO:0004857	enzyme inhibitor activity	8/749	70/18367	0.00747773750710729	0.0775238809861081	RPS20/RPL23/DYNLL1/ANXA5/ANXA1/FAF2/ANXA4/ANXA3	8
GO:0016504	peptidase activator activity	6/749	43/18367	0.00758693306943477	0.0775238809861081	FBLN1/APP/CTSC/CAV1/PCOLCE2/PSME2	6
GO:0003756	protein disulfide isomerase activity	4/749	20/18367	0.00788682257430927	0.0775238809861081	P4HB/PDIA3/PDIA4/PDIA6	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4/749	20/18367	0.00788682257430927	0.0775238809861081	P4HB/PDIA3/PDIA4/PDIA6	4
GO:0019211	phosphatase activator activity	4/749	20/18367	0.00788682257430927	0.0775238809861081	PPP1R15A/B3GAT3/CALM1/CALM2	4
GO:0030506	ankyrin binding	4/749	20/18367	0.00788682257430927	0.0775238809861081	CDH1/PLEC/SPTBN1/ATP1A1	4
GO:0019855	calcium channel inhibitor activity	3/749	11/18367	0.00871845409063918	0.0828732174549769	CALM1/PHPT1/CALM2	3
GO:0022889	serine transmembrane transporter activity	3/749	11/18367	0.00871845409063918	0.0828732174549769	SLC38A2/SLC1A5/SERINC3	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/749	11/18367	0.00871845409063918	0.0828732174549769	DSP/DSG2/DSC2	3
GO:0003727	single-stranded RNA binding	9/749	87/18367	0.00894374808956494	0.0840906749725399	HNRNPDL/ANXA1/HNRNPA1/L1TD1/HNRNPC/EIF4H/SSB/SNRPC/EIF4B	9
GO:0070577	lysine-acetylated histone binding	4/749	21/18367	0.0094335760189825	0.0868089708129773	BRD4/PHIP/BRD2/BRD7	4
GO:0140033	acetylation-dependent protein binding	4/749	21/18367	0.0094335760189825	0.0868089708129773	BRD4/PHIP/BRD2/BRD7	4
GO:0030414	peptidase inhibitor activity	15/749	187/18367	0.00979417063536752	0.0888646264587003	ITIH5/GAPDH/APLP2/SPINT1/APP/CRIM1/SPINT2/SERPINF1/SERPINH1/ROCK1/CST3/TIMP3/TFPI2/SERPINB9/SERPINB1	15
GO:0036002	pre-mRNA binding	7/749	59/18367	0.00986243253183264	0.0888646264587003	SF1/TRA2B/HNRNPA1/SRSF6/CELF1/DDX5/SNRPC	7
GO:0008200	ion channel inhibitor activity	5/749	33/18367	0.0102364454539912	0.0903522991602281	CAV1/RASA1/CALM1/PHPT1/CALM2	5
GO:0031369	translation initiation factor binding	5/749	33/18367	0.0102364454539912	0.0903522991602281	EIF4G1/CELF1/LARP1/EIF2S2/EIF3F	5
GO:0061980	regulatory RNA binding	6/749	46/18367	0.0105200251991404	0.0919173918914792	NEAT1/KCNQ1OT1/SOX4/YBX1/PUM1/HNRNPA1	6
GO:0005201	extracellular matrix structural constituent	14/749	172/18367	0.010928641850695	0.0937892612515326	FBN2/COL14A1/FBN1/FBLN1/LAMA5/EFEMP1/LAMB1/VWA1/LAMC1/COL4A2/TINAGL1/LTBP1/FRAS1/TFPI2	14
GO:0005537	mannose binding	4/749	22/18367	0.0111648421592661	0.0937892612515326	LMAN1/BSG/MANBA/LMAN2	4
GO:0017154	semaphorin receptor activity	3/749	12/18367	0.011276396728508	0.0937892612515326	NRP2/MET/NRP1	3
GO:0017166	vinculin binding	3/749	12/18367	0.011276396728508	0.0937892612515326	DAG1/UTRN/TLN1	3
GO:0045295	gamma-catenin binding	3/749	12/18367	0.011276396728508	0.0937892612515326	CDH1/DSC3/TCF7L2	3
GO:0042393	histone binding	18/749	244/18367	0.0113916429439485	0.0938215430048766	CTSL/BPTF/ATRX/MPHOSPH8/NPM1/BRD4/KMT2C/PHIP/KDM5A/BRD2/CHD2/BAZ1B/RSF1/KDM5B/BRD7/SMARCA2/TBL1X/CKS1B	18
GO:0099106	ion channel regulator activity	12/749	139/18367	0.0114972064260311	0.0938215430048766	AKAP9/CAV1/ATP2B4/PRSS8/DLG1/RASA1/SLC5A3/CALM1/FXYD3/PHPT1/CALM2/YWHAE	12
GO:0016248	channel inhibitor activity	5/749	34/18367	0.0116080729962367	0.0938409639415397	CAV1/RASA1/CALM1/PHPT1/CALM2	5
GO:0015179	L-amino acid transmembrane transporter activity	7/749	61/18367	0.011765157108794	0.094230193510248	SLC3A2/SLC38A1/SLC43A2/SLC38A2/SLC1A5/SLC38A9/SERINC3	7
GO:0051087	chaperone binding	10/749	107/18367	0.0120189279585237	0.095379565909385	LRP2/HSPA5/GRN/CTSC/ERP29/CALR/ATP1A1/DNAJB1/HES1/PTGES3	10
GO:0004714	transmembrane receptor protein tyrosine kinase activity	11/749	124/18367	0.0125562730067772	0.098737965007839	EGFR/NRP2/EFEMP1/CRIM1/MET/EPHB4/FLT1/IGF1R/NRP1/ERBB3/BAZ1B	11
GO:0016853	isomerase activity	13/749	158/18367	0.0127680027318788	0.0993085048677105	P4HB/PDIA3/MIF/NKTR/PDIA4/TPI1/DEGS1/PPIG/ISYNA1/PPIA/PDIA6/PTGES3/CYP2J2	13
GO:0015026	coreceptor activity	6/749	48/18367	0.0128731617307648	0.0993085048677105	LRP1/ITGAV/ITGB1/TGFBR3/LRP5/NRP1	6
GO:0038024	cargo receptor activity	8/749	77/18367	0.0130206657610928	0.0993085048677105	LRP2/LRP1/LGALS3BP/TFRC/COLEC12/MIA3/FOLR1/LRP10	8
GO:0070412	R-SMAD binding	4/749	23/18367	0.0130880572889237	0.0993085048677105	JUN/FOS/DDX5/PARP1	4
GO:0033218	amide binding	26/749	400/18367	0.0134046695882813	0.100826427772725	LRP1/PSAP/LRPAP1/ENPEP/DHCR24/ITM2B/NKTR/CTSV/SLC19A1/IGF1R/PRLR/CALR/MME/FOLR1/PPIG/SLC40A1/CST3/ACADVL/PPIA/SEC61A1/NFKBIA/HADHA/VDAC1/KPNB1/CLTA/VDAC2	26
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	3/749	13/18367	0.0142211733175724	0.106045818273277	DUSP1/DUSP6/DUSP9	3
GO:0050431	transforming growth factor beta binding	4/749	24/18367	0.0152099316089668	0.112449494373985	ITGAV/TGFBR3/LTBP1/LTBP3	4
GO:0016247	channel regulator activity	12/749	145/18367	0.0156676194164438	0.114851616908677	AKAP9/CAV1/ATP2B4/PRSS8/DLG1/RASA1/SLC5A3/CALM1/FXYD3/PHPT1/CALM2/YWHAE	12
GO:0046943	carboxylic acid transmembrane transporter activity	13/749	163/18367	0.0162002540086562	0.117659509810477	SLC26A2/SLC3A2/SLC38A1/SLC43A2/SLC38A2/SLC1A5/SLC27A2/SLC19A1/SLC38A10/SLC38A9/SLC16A12/SERINC3/SLC16A1	13
GO:0015035	protein-disulfide reductase activity	5/749	37/18367	0.0164587291179973	0.117659509810477	P4HB/PDIA3/PDIA4/PDIA6/TXN	5
GO:0046915	transition metal ion transmembrane transporter activity	5/749	37/18367	0.0164587291179973	0.117659509810477	SLC39A10/SLC40A1/SLC39A7/SLC39A1/TMEM165	5
GO:0005342	organic acid transmembrane transporter activity	13/749	164/18367	0.0169636647344576	0.120275163895949	SLC26A2/SLC3A2/SLC38A1/SLC43A2/SLC38A2/SLC1A5/SLC27A2/SLC19A1/SLC38A10/SLC38A9/SLC16A12/SERINC3/SLC16A1	13
GO:0044548	S100 protein binding	3/749	14/18367	0.0175599111718088	0.122494541642054	AHNAK/IQGAP1/CACYBP	3
GO:0140666	annealing activity	3/749	14/18367	0.0175599111718088	0.122494541642054	ANXA1/EIF4H/EIF4B	3
GO:0005516	calmodulin binding	15/749	201/18367	0.0179722941719844	0.124368275670132	EGFR/ATP2B1/IQGAP2/KCNN4/MYH10/IQGAP1/EEA1/SPTAN1/ATP2B4/SPTBN1/SLC9A1/SYT7/VAMP2/DDX5/CNN3	15
GO:0042974	retinoic acid receptor binding	4/749	26/18367	0.0200728167156843	0.137801479833865	FUS/ACTN4/NSD1/HMGA1	4
GO:0015171	amino acid transmembrane transporter activity	8/749	84/18367	0.0210992379363938	0.141705472324453	SLC3A2/SLC38A1/SLC43A2/SLC38A2/SLC1A5/SLC38A10/SLC38A9/SERINC3	8
GO:0003714	transcription corepressor activity	14/749	187/18367	0.0212340587085528	0.141705472324453	N4BP2L2/SF1/TLE4/CCAR1/HSPA1A/RERE/NCOR1/NSD1/KDM5B/BRD7/CITED2/TBL1X/DNAJB1/SIAH2	14
GO:0005041	low-density lipoprotein particle receptor activity	3/749	15/18367	0.0212967761874901	0.141705472324453	LRP2/LRP1/LRP10	3
GO:0015929	hexosaminidase activity	3/749	15/18367	0.0212967761874901	0.141705472324453	HEXA/NAGLU/HEXB	3
GO:0005518	collagen binding	7/749	69/18367	0.0220560528659934	0.14370451863873	COL14A1/CTSL/ADGRG1/ITGB1/SERPINH1/P3H1/PCOLCE2	7
GO:0015459	potassium channel regulator activity	6/749	54/18367	0.0220956080681516	0.14370451863873	AKAP9/CAV1/DLG1/RASA1/SLC5A3/YWHAE	6
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	6/749	54/18367	0.0220956080681516	0.14370451863873	P4HB/ASPH/P3H1/KDM5A/TET2/KDM5B	6
GO:0002020	protease binding	11/749	135/18367	0.0223390543020503	0.144104032277865	ADAMTSL4/LRP1/ITGAV/ITGB1/PSAP/DPP4/OS9/CST3/TIMP3/CLTC/SERPINB9	11
GO:0008013	beta-catenin binding	8/749	85/18367	0.0224902246907651	0.144104032277865	CDH1/KANK1/GJA1/DLG5/GLI3/TCF7L2/TBL1X/SKP1	8
GO:0004190	aspartic-type endopeptidase activity	4/749	27/18367	0.0228235613737725	0.145164563149362	CTSD/NCSTN/SPPL2B/HM13	4
GO:0004713	protein tyrosine kinase activity	11/749	136/18367	0.0234457601604395	0.148033449188176	EGFR/NRP2/EFEMP1/CRIM1/MET/EPHB4/FLT1/IGF1R/NRP1/ERBB3/BAZ1B	11
GO:0004197	cysteine-type endopeptidase activity	10/749	119/18367	0.0236793882138056	0.148425150760448	CTSL/CTSD/CTSC/PDIA3/CTSV/LGMN/GPAA1/USP9X/USP48/USP10	10
GO:0008234	cysteine-type peptidase activity	14/749	190/18367	0.0239659881512783	0.149140861516948	CTSL/CTSD/CTSC/PDIA3/CTSV/LGMN/GPAA1/EIF3H/USP9X/USP27X/USP22/USP48/USP10/EIF3F	14
GO:0015923	mannosidase activity	3/749	16/18367	0.025433272239026	0.154933766379182	MANBA/MAN2A1/MAN1A2	3
GO:0035497	cAMP response element binding	3/749	16/18367	0.025433272239026	0.154933766379182	JUN/CREB3L2/ATF6	3
GO:0050681	androgen receptor binding	4/749	28/18367	0.0257924420330661	0.154933766379182	CALR/FOXP1/NSD1/DDX5	4
GO:0070001	aspartic-type peptidase activity	4/749	28/18367	0.0257924420330661	0.154933766379182	CTSD/NCSTN/SPPL2B/HM13	4
GO:0070325	lipoprotein particle receptor binding	4/749	28/18367	0.0257924420330661	0.154933766379182	HSP90B1/LRP1/LRPAP1/CLTC	4
GO:0008307	structural constituent of muscle	5/749	42/18367	0.0272247441499425	0.162409680618623	KRT19/DAG1/PLEC/ASPH/TPM4	5
GO:0008381	mechanosensitive ion channel activity	3/749	17/18367	0.0299685183050118	0.176345362815205	TMEM150C/TMC5/TMEM63A	3
GO:0046965	retinoid X receptor binding	3/749	17/18367	0.0299685183050118	0.176345362815205	FUS/NSD1/HMGA1	3
GO:0016758	hexosyltransferase activity	14/749	197/18367	0.0313481051551912	0.183216965940814	RPN2/EXTL2/CHPF/HEXA/GALNT11/AGL/B4GAT1/B3GAT3/C1GALT1/C1GALT1C1/FUT8/RPN1/HEXB/PYGL	14
GO:0022829	wide pore channel activity	4/749	30/18367	0.0323961055536344	0.188071351032844	GJA1/GJA5/VDAC1/VDAC2	4
GO:0009055	electron transfer activity	10/749	126/18367	0.0334142036116164	0.192688574160321	COX6A1/GLDC/POR/DEGS1/ASPH/NDUFB9/UQCRH/CYP19A1/COX5A/ETFA	10
GO:0051213	dioxygenase activity	8/749	92/18367	0.0340720051529533	0.195180691770229	P4HB/POR/ASPH/P3H1/KDM5A/RSBN1L/TET2/KDM5B	8
GO:0030228	lipoprotein particle receptor activity	3/749	18/18367	0.0348995047525156	0.195343157288064	LRP2/LRP1/LRP10	3
GO:0033549	MAP kinase phosphatase activity	3/749	18/18367	0.0348995047525156	0.195343157288064	DUSP1/DUSP6/DUSP9	3
GO:0098918	structural constituent of synapse	3/749	18/18367	0.0348995047525156	0.195343157288064	ACTG1/DLG1/ERC1	3
GO:0042826	histone deacetylase binding	10/749	127/18367	0.0350036871441039	0.195343157288064	PKN2/HSPA1A/GLI3/NIPBL/HSPA1B/NCOR1/DHX36/PARP1/HES1/YWHAE	10
GO:0140318	protein transporter activity	4/749	31/18367	0.0360348931569128	0.199808862696985	LRP2/IGF1R/SEC61A1/SEC63	4
GO:0031072	heat shock protein binding	10/749	129/18367	0.0383391016203529	0.21123135606118	HSPA5/TPR/HSPA1A/HSPA1B/DNAJB14/LMAN2/KPNB1/DNAJB1/PTGES3/DNAJC8	10
GO:0016018	cyclosporin A binding	3/749	20/18367	0.0459274196914942	0.246752907038152	NKTR/PPIG/PPIA	3
GO:0016500	protein-hormone receptor activity	3/749	20/18367	0.0459274196914942	0.246752907038152	LGR5/LGR4/IGF1R	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/749	20/18367	0.0459274196914942	0.246752907038152	COX6A1/POR/COX5A	3
GO:0097001	ceramide binding	3/749	20/18367	0.0459274196914942	0.246752907038152	PSAP/VDAC1/VDAC2	3
GO:0015103	inorganic anion transmembrane transporter activity	11/749	152/18367	0.0469779120707052	0.249444845241738	SLC26A2/CLDN4/SLC22A11/SLC12A9/SLC6A4/SLC13A4/GABRE/CLIC3/VDAC1/FXYD3/VDAC2	11
GO:0022853	active ion transmembrane transporter activity	17/749	267/18367	0.0470052136120269	0.249444845241738	ATP2B1/SLC26A2/COX6A1/SLC22A11/SLC12A9/SLC3A2/SLC38A1/SLC38A2/SLC19A1/SLC6A4/SLC13A4/ATP2B4/SLC9A1/SLC5A3/ATP1A1/UQCRH/COX5A	17
GO:0045505	dynein intermediate chain binding	4/749	34/18367	0.0483091438051373	0.254283088032758	DYNC1H1/DYNLL1/DYNLRB1/DYNLT1	4
GO:0043539	protein serine/threonine kinase activator activity	5/749	49/18367	0.0485048665033585	0.254283088032758	IQGAP1/CALM1/IGF2/CALM2/CKS1B	5
GO:0060090	molecular adaptor activity	22/749	369/18367	0.0490453781849355	0.255567783915477	AKAP9/COL14A1/SYNE2/CAV1/IQGAP1/ANK3/DLG5/CUX1/FRMD4A/SLC9A1/DDB1/SERINC1/NCSTN/EIF4G1/DLG1/AKAP13/VAMP2/RB1CC1/RAD50/OBSL1/SKP1/SDCBP	22
GO:0005385	zinc ion transmembrane transporter activity	3/749	21/18367	0.0520097269702462	0.264637728407429	SLC39A10/SLC39A7/SLC39A1	3
GO:0015662	P-type ion transporter activity	3/749	21/18367	0.0520097269702462	0.264637728407429	ATP2B1/ATP2B4/ATP1A1	3
GO:0140358	P-type transmembrane transporter activity	3/749	21/18367	0.0520097269702462	0.264637728407429	ATP2B1/ATP2B4/ATP1A1	3
GO:0140416	transcription regulator inhibitor activity	3/749	21/18367	0.0520097269702462	0.264637728407429	PURA/DDIT3/ID1	3
GO:0042162	telomeric DNA binding	4/749	36/18367	0.057619486129328	0.285689068938593	UPF2/HNRNPA1/PURA/RAD50	4
GO:0043394	proteoglycan binding	4/749	36/18367	0.057619486129328	0.285689068938593	CTSL/LRP1/PTPRF/SDCBP	4
GO:0019955	cytokine binding	10/749	139/18367	0.0583035226633158	0.285689068938593	CSF3R/NRP2/ITGAV/ITGB1/TGFBR3/IL6ST/LTBP1/NRP1/PRLR/LTBP3	10
GO:0008093	cytoskeletal anchor activity	3/749	22/18367	0.058458919308822	0.285689068938593	ANK3/OBSL1/SDCBP	3
GO:0015296	anion:cation symporter activity	3/749	22/18367	0.058458919308822	0.285689068938593	SLC12A9/SLC6A4/SLC13A4	3
GO:0055106	ubiquitin-protein transferase regulator activity	3/749	22/18367	0.058458919308822	0.285689068938593	RPS20/RPL23/UBE2L3	3
GO:0072349	modified amino acid transmembrane transporter activity	3/749	22/18367	0.058458919308822	0.285689068938593	GJA1/SLC19A1/SLC16A12	3
GO:0008190	eukaryotic initiation factor 4E binding	2/749	10/18367	0.0601462690530921	0.285929658215626	EIF4G1/LARP1	2
GO:0008239	dipeptidyl-peptidase activity	2/749	10/18367	0.0601462690530921	0.285929658215626	CTSC/DPP4	2
GO:0015924	mannosyl-oligosaccharide mannosidase activity	2/749	10/18367	0.0601462690530921	0.285929658215626	MAN2A1/MAN1A2	2
GO:0051880	G-quadruplex DNA binding	2/749	10/18367	0.0601462690530921	0.285929658215626	DHX36/RAD50	2
GO:0030674	protein-macromolecule adaptor activity	18/749	296/18367	0.0601609223066403	0.285929658215626	COL14A1/SYNE2/CAV1/IQGAP1/ANK3/DLG5/CUX1/FRMD4A/SLC9A1/DDB1/SERINC1/NCSTN/AKAP13/VAMP2/RAD50/OBSL1/SKP1/SDCBP	18
GO:0042562	hormone binding	7/749	86/18367	0.0613707421005375	0.290085748180136	LRP2/EGFR/IGF1R/PRLR/CALR/SLC40A1/ATP1A1	7
GO:0005158	insulin receptor binding	3/749	23/18367	0.0652645486118067	0.303515239511897	IGF1R/PHIP/IGF2	3
GO:0050750	low-density lipoprotein particle receptor binding	3/749	23/18367	0.0652645486118067	0.303515239511897	HSP90B1/LRPAP1/CLTC	3
GO:0140103	catalytic activity, acting on a glycoprotein	3/749	23/18367	0.0652645486118067	0.303515239511897	C1GALT1/C1GALT1C1/FUT8	3
GO:0042277	peptide binding	19/749	321/18367	0.0675637180368357	0.312527358833492	LRP1/LRPAP1/ENPEP/DHCR24/ITM2B/NKTR/CTSV/IGF1R/PRLR/CALR/MME/PPIG/SLC40A1/CST3/PPIA/SEC61A1/NFKBIA/KPNB1/CLTA	19
GO:0005544	calcium-dependent phospholipid binding	5/749	54/18367	0.0683650396647675	0.314274576685485	ANXA5/ANXA1/SYT7/ANXA4/ANXA3	5
GO:0019888	protein phosphatase regulator activity	7/749	89/18367	0.0710837104826943	0.314274576685485	BOD1L1/PPP1R15A/PPP1R10/B3GAT3/PHACTR2/CALM1/CALM2	7
GO:0000774	adenyl-nucleotide exchange factor activity	2/749	11/18367	0.0715746723780817	0.314274576685485	SIL1/PFN1	2
GO:0002162	dystroglycan binding	2/749	11/18367	0.0715746723780817	0.314274576685485	DAG1/PLEC	2
GO:0005078	MAP-kinase scaffold activity	2/749	11/18367	0.0715746723780817	0.314274576685485	IQGAP1/AKAP13	2
GO:0005536	glucose binding	2/749	11/18367	0.0715746723780817	0.314274576685485	PYGL/UGP2	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/749	11/18367	0.0715746723780817	0.314274576685485	P4HB/PCYOX1	2
GO:0043522	leucine zipper domain binding	2/749	11/18367	0.0715746723780817	0.314274576685485	ERC1/DDIT3	2
GO:0046975	histone methyltransferase activity (H3-K36 specific)	2/749	11/18367	0.0715746723780817	0.314274576685485	ASH1L/NSD1	2
GO:0099186	structural constituent of postsynapse	2/749	11/18367	0.0715746723780817	0.314274576685485	ACTG1/DLG1	2
GO:0004175	endopeptidase activity	24/749	430/18367	0.0753092287363293	0.329002438671338	CTSL/ADAMTS6/CTSD/CTSC/PDIA3/ADAMTS1/CTSV/DPP4/MMP15/TMEM59/MME/PRSS8/LGMN/NCSTN/GPAA1/ST14/ADAMTS19/SPPL2B/MBTPS1/USP9X/YME1L1/USP48/HM13/USP10	24
GO:0070063	RNA polymerase binding	6/749	73/18367	0.0770129366014816	0.333075037779425	PKN2/BRD4/PABPN1/STOM/NCOA3/RTF1	6
GO:0030374	nuclear receptor coactivator activity	5/749	56/18367	0.0773966272759127	0.333075037779425	CCAR1/ACTN4/NCOA3/USP22/HMGA1	5
GO:0051287	NAD binding	5/749	56/18367	0.0773966272759127	0.333075037779425	GAPDH/LDHA/HADHA/PARP1/HPGD	5
GO:0004177	aminopeptidase activity	4/749	40/18367	0.0788812761937081	0.337783682710681	ENPEP/CTSV/DPP4/MMP15	4
GO:0035035	histone acetyltransferase binding	3/749	25/18367	0.079898676625042	0.338786055297359	EGR1/GLI3/CITED2	3
GO:0051019	mitogen-activated protein kinase binding	3/749	25/18367	0.079898676625042	0.338786055297359	DUSP1/IQGAP1/TPR	3
GO:0017022	myosin binding	6/749	74/18367	0.0810754766980997	0.342098962652957	FUS/TRIOBP/VAMP2/MYL12B/RHOA/RAB11A	6
GO:0005024	transforming growth factor beta-activated receptor activity	2/749	12/18367	0.0836343275079963	0.342861105660743	TGFBR3/LTBP1	2
GO:0005095	GTPase inhibitor activity	2/749	12/18367	0.0836343275079963	0.342861105660743	IQGAP2/IQGAP1	2
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/749	12/18367	0.0836343275079963	0.342861105660743	BRD4/CDK6	2
GO:0030955	potassium ion binding	2/749	12/18367	0.0836343275079963	0.342861105660743	ATP1A1/PKM	2
GO:0031543	peptidyl-proline dioxygenase activity	2/749	12/18367	0.0836343275079963	0.342861105660743	P4HB/P3H1	2
GO:0043047	single-stranded telomeric DNA binding	2/749	12/18367	0.0836343275079963	0.342861105660743	HNRNPA1/RAD50	2
GO:0016859	cis-trans isomerase activity	4/749	41/18367	0.0847292005338198	0.344088067895559	NKTR/DEGS1/PPIG/PPIA	4
GO:0030331	estrogen receptor binding	4/749	41/18367	0.0847292005338198	0.344088067895559	FUS/ISL1/NSD1/PARP1	4
GO:0019903	protein phosphatase binding	10/749	150/18367	0.0869743399216595	0.349595727894208	EGFR/HSP90B1/MET/KCNN4/BOD1L1/IQGAP1/PPP1R15A/ATP2B4/SLC9A1/PPP1R9A	10
GO:0016757	glycosyltransferase activity	16/749	270/18367	0.0871547811395383	0.349595727894208	RPN2/EXTL2/CHPF/HEXA/GALNT11/AGL/B4GAT1/B3GAT3/C1GALT1/C1GALT1C1/GXYLT1/FUT8/RPN1/PARP1/HEXB/PYGL	16
GO:0030371	translation repressor activity	3/749	26/18367	0.0877020496566974	0.349595727894208	PURA/CELF1/CIRBP	3
GO:0097602	cullin family protein binding	3/749	26/18367	0.0877020496566974	0.349595727894208	DDB1/SKP1/ANAPC11	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	11/749	170/18367	0.0884181022349279	0.350833295565195	P4HB/POR/DEGS1/ASPH/P3H1/KDM5A/TET2/KDM5B/CYP11A1/CYP2J2/CYP19A1	11
GO:0008237	metallopeptidase activity	12/749	190/18367	0.0890829051284118	0.351857136694412	ADAMTS6/ENPEP/TFRC/ADAMTS1/MMP15/MME/CPD/ADAMTS19/EIF3H/CPQ/YME1L1/EIF3F	12
GO:0023026	MHC class II protein complex binding	3/749	27/18367	0.095811860692063	0.364939766633728	CD81/PKM/YWHAE	3
GO:0045499	chemorepellent activity	3/749	27/18367	0.095811860692063	0.364939766633728	SEMA6A/SEMA6D/DPP4	3
GO:0051959	dynein light intermediate chain binding	3/749	27/18367	0.095811860692063	0.364939766633728	DYNC1H1/DYNLL1/HOOK2	3
GO:0005542	folic acid binding	2/749	13/18367	0.0962549009971644	0.364939766633728	SLC19A1/FOLR1	2
GO:0008179	adenylate cyclase binding	2/749	13/18367	0.0962549009971644	0.364939766633728	CALM1/CALM2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/749	13/18367	0.0962549009971644	0.364939766633728	SLC26A2/SLC13A4	2
GO:0031432	titin binding	2/749	13/18367	0.0962549009971644	0.364939766633728	CALM1/CALM2	2
GO:0060590	ATPase regulator activity	2/749	13/18367	0.0962549009971644	0.364939766633728	SIL1/PFN1	2
GO:0140299	small molecule sensor activity	2/749	13/18367	0.0962549009971644	0.364939766633728	TMEM63A/EFHD1	2
GO:0004180	carboxypeptidase activity	4/749	43/18367	0.0970360073130143	0.364939766633728	CTSA/CPD/CPVL/CPQ	4
GO:0005246	calcium channel regulator activity	4/749	43/18367	0.0970360073130143	0.364939766633728	CALM1/PHPT1/CALM2/YWHAE	4
GO:0043621	protein self-association	5/749	61/18367	0.102609971900162	0.384232145859915	SLC2A1/CTSC/PLEC/VAMP2/FOXP1	5
GO:0008375	acetylglucosaminyltransferase activity	4/749	44/18367	0.103485414764062	0.385840016253937	EXTL2/HEXA/B4GAT1/HEXB	4
GO:0051861	glycolipid binding	3/749	28/18367	0.104214190931143	0.386889592941795	PSAP/GPAA1/CLN3	3
GO:0019902	phosphatase binding	12/749	196/18367	0.10572150298111	0.390808119994272	EGFR/HSP90B1/MET/CTSC/KCNN4/BOD1L1/IQGAP1/PPP1R15A/ATP2B4/SLC9A1/DLG1/PPP1R9A	12
GO:1990841	promoter-specific chromatin binding	5/749	62/18367	0.108088758158955	0.395839680874627	EGR1/ISL1/NIPBL/POLR2A/DDX5	5
GO:0015373	anion:sodium symporter activity	2/749	14/18367	0.109370732634724	0.395839680874627	SLC6A4/SLC13A4	2
GO:0032977	membrane insertase activity	2/749	14/18367	0.109370732634724	0.395839680874627	EMC1/EMC10	2
GO:0043023	ribosomal large subunit binding	2/749	14/18367	0.109370732634724	0.395839680874627	NPM1/NEMF	2
GO:0071837	HMG box domain binding	2/749	14/18367	0.109370732634724	0.395839680874627	JUN/GATA3	2
GO:0046625	sphingolipid binding	3/749	29/18367	0.112894769699995	0.403528825580561	PSAP/VDAC1/VDAC2	3
GO:0051059	NF-kappaB binding	3/749	29/18367	0.112894769699995	0.403528825580561	NPM1/NFKBIA/ANXA4	3
GO:0051787	misfolded protein binding	3/749	29/18367	0.112894769699995	0.403528825580561	HSPA5/HSPA1A/HSPA1B	3
GO:0005496	steroid binding	7/749	100/18367	0.114016213802773	0.405860184935796	CAV1/ESRRA/CD81/ATP1A1/VDAC1/HSD17B1/VDAC2	7
GO:0015291	secondary active transmembrane transporter activity	14/749	240/18367	0.11449142747444	0.405881494940125	SLC26A2/SLC22A11/SLC12A9/SLC3A2/SLC38A1/SLC38A2/SLC1A5/SLC19A1/SLC6A4/SLC13A4/SLC9A1/SLC16A12/SLC5A3/SLC16A1	14
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/749	30/18367	0.121839065716257	0.423962297659816	SLC26A2/SLC1A5/SLC19A1	3
GO:0001846	opsonin binding	2/749	15/18367	0.122920572088144	0.423962297659816	ITGAV/CALR	2
GO:0004559	alpha-mannosidase activity	2/749	15/18367	0.122920572088144	0.423962297659816	MAN2A1/MAN1A2	2
GO:0010851	cyclase regulator activity	2/749	15/18367	0.122920572088144	0.423962297659816	CALM1/CALM2	2
GO:0071933	Arp2/3 complex binding	2/749	15/18367	0.122920572088144	0.423962297659816	IQGAP2/WASF2	2
GO:0098847	sequence-specific single stranded DNA binding	2/749	15/18367	0.122920572088144	0.423962297659816	HNRNPA1/RAD50	2
GO:0004725	protein tyrosine phosphatase activity	7/749	102/18367	0.123022585794929	0.423962297659816	DUSP1/DUSP6/PTPRF/PTPRA/PTPN12/DUSP9/PTPN14	7
GO:0035254	glutamate receptor binding	4/749	47/18367	0.123954392239088	0.42547837018576	FUS/CANX/CALM1/MYL12A	4
GO:0003697	single-stranded DNA binding	8/749	123/18367	0.129947142689799	0.4438994158826	ANXA1/YBX1/HNRNPA1/PURA/DHX36/RAD50/PCBP2/RTF1	8
GO:0019887	protein kinase regulator activity	12/749	204/18367	0.130568116705387	0.4438994158826	CCNL1/IQGAP1/NPM1/KIDINS220/ERBB3/CALM1/HSPB1/IGF2/CALM2/CSNK2B/CKS1B/CCNE1	12
GO:0031210	phosphatidylcholine binding	3/749	31/18367	0.131032369919044	0.4438994158826	NF1/VDAC1/VDAC2	3
GO:0043022	ribosome binding	5/749	66/18367	0.131373699960631	0.4438994158826	HSPA5/RPN2/CCDC47/SEC61A1/EIF5A	5
GO:0015293	symporter activity	9/749	144/18367	0.134607239702758	0.451805113611342	SLC12A9/SLC38A1/SLC38A2/SLC1A5/SLC6A4/SLC13A4/SLC16A12/SLC5A3/SLC16A1	9
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/749	16/18367	0.136847329209447	0.451805113611342	PURA/CELF1	2
GO:0005283	amino acid:sodium symporter activity	2/749	16/18367	0.136847329209447	0.451805113611342	SLC38A1/SLC38A2	2
GO:0016208	AMP binding	2/749	16/18367	0.136847329209447	0.451805113611342	ACSS1/PYGL	2
GO:0070403	NAD+ binding	2/749	16/18367	0.136847329209447	0.451805113611342	HADHA/HPGD	2
GO:1990380	Lys48-specific deubiquitinase activity	2/749	16/18367	0.136847329209447	0.451805113611342	USP9X/USP27X	2
GO:0140658	ATP-dependent chromatin remodeler activity	3/749	32/18367	0.140459870462045	0.461968775474028	ATRX/CHD2/SMARCA2	3
GO:0005253	anion channel activity	6/749	87/18367	0.144167680064945	0.463473862732209	CLDN4/GABRE/CLIC3/VDAC1/FXYD3/VDAC2	6
GO:0015485	cholesterol binding	4/749	50/18367	0.145981923512986	0.463473862732209	CAV1/CD81/VDAC1/VDAC2	4
GO:0016887	ATP hydrolysis activity	15/749	272/18367	0.146553978376264	0.463473862732209	ATP2B1/HSPA5/ATRX/ATP2B4/HSPA1A/KIF5B/ATP10D/HSPA1B/ATP1A1/DDX17/CHD2/DDX46/DHX36/DDX5/RHOBTB3	15
GO:0019208	phosphatase regulator activity	7/749	107/18367	0.147055624285724	0.463473862732209	BOD1L1/PPP1R15A/PPP1R10/B3GAT3/PHACTR2/CALM1/CALM2	7
GO:0061659	ubiquitin-like protein ligase activity	17/749	316/18367	0.149963874889324	0.463473862732209	MYCBP2/UFL1/NHLRC3/RNF43/HERC2/ZNRF3/TRIM44/RANBP2/RBBP6/HECTD1/RNF13/HUWE1/SIAH2/SIAH1/CDC42/ANAPC11/UBE2C	17
GO:0000400	four-way junction DNA binding	2/749	17/18367	0.151097837330038	0.463473862732209	HMGB3/YY1	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/749	17/18367	0.151097837330038	0.463473862732209	PTPRF/PTPRA	2
GO:0005324	long-chain fatty acid transporter activity	2/749	17/18367	0.151097837330038	0.463473862732209	SLC2A1/SLC27A2	2
GO:0008308	voltage-gated anion channel activity	2/749	17/18367	0.151097837330038	0.463473862732209	VDAC1/VDAC2	2
GO:0015116	sulfate transmembrane transporter activity	2/749	17/18367	0.151097837330038	0.463473862732209	SLC26A2/SLC13A4	2
GO:0015377	cation:chloride symporter activity	2/749	17/18367	0.151097837330038	0.463473862732209	SLC12A9/SLC6A4	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/749	17/18367	0.151097837330038	0.463473862732209	PTPRF/PTPRA	2
GO:0030275	LRR domain binding	2/749	17/18367	0.151097837330038	0.463473862732209	ERC1/DDIT3	2
GO:0031420	alkali metal ion binding	2/749	17/18367	0.151097837330038	0.463473862732209	ATP1A1/PKM	2
GO:0031489	myosin V binding	2/749	17/18367	0.151097837330038	0.463473862732209	FUS/RAB11A	2
GO:0034185	apolipoprotein binding	2/749	17/18367	0.151097837330038	0.463473862732209	LRP1/CANX	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/749	17/18367	0.151097837330038	0.463473862732209	KMT2C/ASH1L	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/749	17/18367	0.151097837330038	0.463473862732209	C1GALT1/C1GALT1C1	2
GO:0070064	proline-rich region binding	2/749	17/18367	0.151097837330038	0.463473862732209	PFN1/RABAC1	2
GO:0051018	protein kinase A binding	4/749	51/18367	0.153641673296199	0.469611474915944	AKAP9/CRYBG3/AKAP13/WASF2	4
GO:0022804	active transmembrane transporter activity	21/749	406/18367	0.158023123393108	0.481302823010699	ATP2B1/SLC26A2/COX6A1/SLC22A11/SLC12A9/SLC3A2/SLC38A1/SLC38A2/SLC1A5/SLC19A1/SLC6A4/SLC13A4/ATP2B4/SLC9A1/SLC16A12/SLC5A3/ATP1A1/NDUFB9/SLC16A1/UQCRH/COX5A	21
GO:0008376	acetylgalactosaminyltransferase activity	3/749	34/18367	0.159958098814554	0.48210367761181	EXTL2/CHPF/GALNT11	3
GO:0015020	glucuronosyltransferase activity	3/749	34/18367	0.159958098814554	0.48210367761181	CHPF/B4GAT1/B3GAT3	3
GO:0043548	phosphatidylinositol 3-kinase binding	3/749	34/18367	0.159958098814554	0.48210367761181	IGF1R/ATP1A1/CALM1	3
GO:1901682	sulfur compound transmembrane transporter activity	4/749	52/18367	0.161449126064592	0.484907965437056	SLC26A2/GJA1/SLC13A4/SLC19A3	4
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/749	18/18367	0.165622628902228	0.492314687286693	MARVELD3/CDC42	2
GO:0070122	isopeptidase activity	2/749	18/18367	0.165622628902228	0.492314687286693	EIF3H/EIF3F	2
GO:0140597	protein carrier activity	2/749	18/18367	0.165622628902228	0.492314687286693	EMC1/EMC10	2
GO:0008094	ATP-dependent activity, acting on DNA	7/749	111/18367	0.167753774131394	0.49694183090293	BPTF/ATRX/ANXA1/CHD2/DHX36/RAD50/SMARCA2	7
GO:0000049	tRNA binding	5/749	72/18367	0.170063595385401	0.498661050875838	EEF1A1/IARS2/NEMF/EIF2AK4/SSB	5
GO:0003678	DNA helicase activity	5/749	72/18367	0.170063595385401	0.498661050875838	ATRX/ANXA1/CHD2/DHX36/RAD50	5
GO:0008235	metalloexopeptidase activity	5/749	72/18367	0.170063595385401	0.498661050875838	ENPEP/TFRC/MMP15/CPD/CPQ	5
GO:0004721	phosphoprotein phosphatase activity	10/749	174/18367	0.174193810897678	0.509046102792202	DUSP1/DUSP6/PTPRF/DLG1/PTPRA/PTPN12/DUSP9/CTDSPL/PTPN14/PHPT1	10
GO:0015370	solute:sodium symporter activity	5/749	73/18367	0.176905555590101	0.513501025454488	SLC38A1/SLC38A2/SLC6A4/SLC13A4/SLC5A3	5
GO:0140104	molecular carrier activity	5/749	73/18367	0.176905555590101	0.513501025454488	EMC1/EMC10/KPNB1/RAN/HBA2	5
GO:0000217	DNA secondary structure binding	3/749	36/18367	0.180215608767187	0.516639073800886	HMGB3/YY1/HMGA1	3
GO:0023023	MHC protein complex binding	3/749	36/18367	0.180215608767187	0.516639073800886	CD81/PKM/YWHAE	3
GO:0004129	cytochrome-c oxidase activity	2/749	19/18367	0.180375722876147	0.516639073800886	COX6A1/COX5A	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/749	19/18367	0.180375722876147	0.516639073800886	TGFBR3/LTBP1	2
GO:0019905	syntaxin binding	5/749	74/18367	0.183849764205463	0.523752893836093	TMED9/SLC6A4/SYT7/VAMP2/RAB11A	5
GO:0101005	deubiquitinase activity	7/749	114/18367	0.184070381186326	0.523752893836093	EIF3H/USP9X/USP27X/USP22/USP48/USP10/EIF3F	7
GO:0005080	protein kinase C binding	4/749	55/18367	0.185690054141341	0.526629169941837	ITGAV/DSP/PRKCSH/HSPB1	4
GO:0004386	helicase activity	9/749	156/18367	0.187460333320456	0.529912380137891	ATRX/ANXA1/DDX17/CHD2/DDX46/DHX36/RAD50/SMARCA2/DDX5	9
GO:0005109	frizzled binding	3/749	37/18367	0.1905926917057	0.537011981516061	RNF43/ZNRF3/SDCBP	3
GO:0045309	protein phosphorylated amino acid binding	4/749	56/18367	0.194020317746374	0.543237865253852	PFN1/RASA1/RTF1/YWHAE	4
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/749	20/18367	0.195314423229998	0.543237865253852	CDS1/GNPTAB	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/749	20/18367	0.195314423229998	0.543237865253852	GNAQ/GNA12	2
GO:0042288	MHC class I protein binding	2/749	20/18367	0.195314423229998	0.543237865253852	BCAP31/TUBB4B	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/749	38/18367	0.201116287959243	0.555800604104617	NKTR/PPIG/PPIA	3
GO:0008395	steroid hydroxylase activity	3/749	38/18367	0.201116287959243	0.555800604104617	CYP11A1/CYP2J2/CYP19A1	3
GO:0140030	modification-dependent protein binding	9/749	160/18367	0.20685478953244	0.569838831036817	BPTF/ATRX/AGL/MPHOSPH8/BRD4/PHIP/KDM5A/BRD2/BRD7	9
GO:0005243	gap junction channel activity	2/749	21/18367	0.210399128099445	0.57593432217095	GJA1/GJA5	2
GO:0051010	microtubule plus-end binding	2/749	21/18367	0.210399128099445	0.57593432217095	CLIP1/DST	2
GO:0050997	quaternary ammonium group binding	3/749	39/18367	0.211772417182498	0.576047612776291	NF1/VDAC1/VDAC2	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/749	39/18367	0.211772417182498	0.576047612776291	UBE2L3/UBE2C/UFC1	3
GO:0003924	GTPase activity	17/749	337/18367	0.216492019948618	0.587039489829325	EEF1A1/RHOB/RASA1/GNAQ/IFT27/GNA12/ARHGAP5/TUFM/ARL4A/RAN/RHOBTB3/CDC42/TUBA1C/RHOA/TUBA1B/RAB11A/TUBB4B	17
GO:0003925	G protein activity	3/749	40/18367	0.222547374559967	0.591327496564876	CDC42/RHOA/RAB11A	3
GO:0017080	sodium channel regulator activity	3/749	40/18367	0.222547374559967	0.591327496564876	ATP2B4/PRSS8/FXYD3	3
GO:0042287	MHC protein binding	3/749	40/18367	0.222547374559967	0.591327496564876	CD81/BCAP31/TUBB4B	3
GO:0000062	fatty-acyl-CoA binding	2/749	22/18367	0.225593148978507	0.591327496564876	ACADVL/HADHA	2
GO:0005355	glucose transmembrane transporter activity	2/749	22/18367	0.225593148978507	0.591327496564876	SLC2A1/SLC5A3	2
GO:0005416	amino acid:cation symporter activity	2/749	22/18367	0.225593148978507	0.591327496564876	SLC38A1/SLC38A2	2
GO:0008320	protein transmembrane transporter activity	2/749	22/18367	0.225593148978507	0.591327496564876	SEC61A1/SEC63	2
GO:0015149	hexose transmembrane transporter activity	2/749	22/18367	0.225593148978507	0.591327496564876	SLC2A1/SLC5A3	2
GO:0017075	syntaxin-1 binding	2/749	22/18367	0.225593148978507	0.591327496564876	SLC6A4/VAMP2	2
GO:0030742	GTP-dependent protein binding	2/749	22/18367	0.225593148978507	0.591327496564876	EEA1/CDC42	2
GO:0070034	telomerase RNA binding	2/749	22/18367	0.225593148978507	0.591327496564876	DHX36/HNRNPC	2
GO:0032934	sterol binding	4/749	60/18367	0.228405894255695	0.596891536347965	CAV1/CD81/VDAC1/VDAC2	4
GO:0008194	UDP-glycosyltransferase activity	8/749	143/18367	0.229225987527352	0.597230359069759	EXTL2/CHPF/HEXA/GALNT11/B4GAT1/B3GAT3/GXYLT1/HEXB	8
GO:0030295	protein kinase activator activity	6/749	101/18367	0.230276237235813	0.598165000627562	IQGAP1/ERBB3/CALM1/IGF2/CALM2/CKS1B	6
GO:0030215	semaphorin receptor binding	2/749	23/18367	0.240862539489622	0.62192864674186	SEMA6A/SEMA6D	2
GO:1901567	fatty acid derivative binding	2/749	23/18367	0.240862539489622	0.62192864674186	ACADVL/HADHA	2
GO:0019787	ubiquitin-like protein transferase activity	22/749	458/18367	0.243676948820349	0.623617754330675	MYCBP2/UFL1/NHLRC3/RNF43/TTC3/HERC2/ZNRF3/LMO7/TRIM44/RANBP2/RBBP6/HECTD1/RNF13/KLHL42/HUWE1/SIAH2/SIAH1/CDC42/ANAPC11/UBE2L3/UBE2C/UFC1	22
GO:0019207	kinase regulator activity	12/749	233/18367	0.243748073622716	0.623617754330675	CCNL1/IQGAP1/NPM1/KIDINS220/ERBB3/CALM1/HSPB1/IGF2/CALM2/CSNK2B/CKS1B/CCNE1	12
GO:0001046	core promoter sequence-specific DNA binding	3/749	42/18367	0.244400484067166	0.623617754330675	FOS/NPM1/FOXP1	3
GO:0019205	nucleobase-containing compound kinase activity	3/749	42/18367	0.244400484067166	0.623617754330675	DLG1/N4BP2/NME3	3
GO:0019783	ubiquitin-like protein-specific protease activity	7/749	125/18367	0.248863862902394	0.633138945325208	EIF3H/USP9X/USP27X/USP22/USP48/USP10/EIF3F	7
GO:0015294	solute:cation symporter activity	6/749	104/18367	0.250559762853888	0.635584149174819	SLC12A9/SLC38A1/SLC38A2/SLC6A4/SLC13A4/SLC5A3	6
GO:0018024	histone-lysine N-methyltransferase activity	3/749	43/18367	0.255452819823728	0.642841717097012	KMT2C/ASH1L/NSD1	3
GO:0030544	Hsp70 protein binding	3/749	43/18367	0.255452819823728	0.642841717097012	DNAJB14/DNAJB1/DNAJC8	3
GO:0015145	monosaccharide transmembrane transporter activity	2/749	24/18367	0.256175933244711	0.642841717097012	SLC2A1/SLC5A3	2
GO:0005096	GTPase activator activity	22/749	462/18367	0.256393517223664	0.642841717097012	JUN/IQGAP2/MYCBP2/IQGAP1/HACD3/NRP1/ARHGAP21/HERC2/NF1/EEF1B2/ADRB1/AKAP13/RANBP2/RASA1/NUCB1/GNAQ/SYDE2/RABGAP1/ARHGAP5/DOCK8/EPS8L1/RANBP1	22
GO:0061630	ubiquitin protein ligase activity	15/749	304/18367	0.260434823318558	0.651087058296396	MYCBP2/NHLRC3/RNF43/HERC2/ZNRF3/TRIM44/RBBP6/HECTD1/RNF13/HUWE1/SIAH2/SIAH1/CDC42/ANAPC11/UBE2C	15
GO:0046982	protein heterodimerization activity	16/749	328/18367	0.265925753917931	0.662898493195996	ITGB1/P4HB/TENM3/HEXA/CAV1/JAM3/ADRB1/ATP1A1/ATF6/ERBB3/DDIT3/EPAS1/RAN/TPM4/YWHAE/SDCBP	16
GO:0019209	kinase activator activity	6/749	107/18367	0.27131983511048	0.663421744762413	IQGAP1/ERBB3/CALM1/IGF2/CALM2/CKS1B	6
GO:0005112	Notch binding	2/749	25/18367	0.271504390342074	0.663421744762413	AAK1/GALNT11	2
GO:0005227	calcium activated cation channel activity	2/749	25/18367	0.271504390342074	0.663421744762413	KCNN4/TMEM63A	2
GO:0008266	poly(U) RNA binding	2/749	25/18367	0.271504390342074	0.663421744762413	HNRNPC/SSB	2
GO:0034237	protein kinase A regulatory subunit binding	2/749	25/18367	0.271504390342074	0.663421744762413	AKAP9/WASF2	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/749	25/18367	0.271504390342074	0.663421744762413	ZFP36L1/DHX36	2
GO:0120227	acyl-CoA binding	2/749	25/18367	0.271504390342074	0.663421744762413	ACADVL/HADHA	2
GO:0005506	iron ion binding	8/749	151/18367	0.274962723375195	0.669979593576179	FTH1/CALR/P3H1/TET2/CYP11A1/CYP2J2/HBA2/CYP19A1	8
GO:0015081	sodium ion transmembrane transporter activity	8/749	152/18367	0.280854391933881	0.674080891048333	SLC3A2/SLC38A1/SLC38A2/SLC6A4/SLC13A4/SLC9A1/SLC5A3/ATP1A1	8
GO:0002039	p53 binding	4/749	66/18367	0.282418968691136	0.674080891048333	BRD4/BRD7/TRIM29/USP10	4
GO:0008198	ferrous iron binding	2/749	26/18367	0.286821252065856	0.674080891048333	FTH1/TET2	2
GO:0004864	protein phosphatase inhibitor activity	3/749	46/18367	0.288965569265404	0.674080891048333	BOD1L1/PPP1R10/PHACTR2	3
GO:0051219	phosphoprotein binding	5/749	88/18367	0.289489990211945	0.674080891048333	PFN1/RASA1/PRKCSH/RTF1/YWHAE	5
GO:0008047	enzyme activator activity	6/749	110/18367	0.292477203114865	0.674080891048333	PSAP/DDOST/MMP15/CTSA/CALM1/CALM2	6
GO:0004222	metalloendopeptidase activity	6/749	111/18367	0.299604256199635	0.674080891048333	ADAMTS6/ADAMTS1/MMP15/MME/ADAMTS19/YME1L1	6
GO:0005044	scavenger receptor activity	3/749	47/18367	0.30021633133538	0.674080891048333	LRP1/LGALS3BP/COLEC12	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/749	47/18367	0.30021633133538	0.674080891048333	DUSP1/DUSP6/DUSP9	3
GO:0019829	ATPase-coupled cation transmembrane transporter activity	3/749	47/18367	0.30021633133538	0.674080891048333	ATP2B1/ATP2B4/ATP1A1	3
GO:0008139	nuclear localization sequence binding	2/749	27/18367	0.302102003375759	0.674080891048333	NFKBIA/KPNB1	2
GO:0015215	nucleotide transmembrane transporter activity	2/749	27/18367	0.302102003375759	0.674080891048333	SLC19A1/SLC25A36	2
GO:0015491	cation:cation antiporter activity	2/749	27/18367	0.302102003375759	0.674080891048333	SLC3A2/SLC9A1	2
GO:0016405	CoA-ligase activity	2/749	27/18367	0.302102003375759	0.674080891048333	ACSS1/SLC27A2	2
GO:0022884	macromolecule transmembrane transporter activity	2/749	27/18367	0.302102003375759	0.674080891048333	SEC61A1/SEC63	2
GO:0035255	ionotropic glutamate receptor binding	2/749	27/18367	0.302102003375759	0.674080891048333	FUS/CANX	2
GO:0051119	sugar transmembrane transporter activity	2/749	27/18367	0.302102003375759	0.674080891048333	SLC2A1/SLC5A3	2
GO:0051393	alpha-actinin binding	2/749	27/18367	0.302102003375759	0.674080891048333	DAG1/PDLIM2	2
GO:0070006	metalloaminopeptidase activity	2/749	27/18367	0.302102003375759	0.674080891048333	ENPEP/MMP15	2
GO:0046873	metal ion transmembrane transporter activity	20/749	430/18367	0.304263151320524	0.674080891048333	ATP2B1/ITGAV/SLC39A10/KCNN4/SLC12A9/SLC3A2/SLC38A1/SLC38A2/SLC6A4/SLC13A4/ATP2B4/SLC9A1/SLC40A1/SLC39A7/SLC5A3/ATP1A1/TUSC3/SLC39A1/TMEM165/SEC61A1	20
GO:0003730	mRNA 3'-UTR binding	10/749	201/18367	0.305299309537698	0.674080891048333	FUS/ZFP36L1/PUM1/DHX36/CELF1/LARP1/CIRBP/DDX5/HNRNPC/IGF2BP3	10
GO:0043177	organic acid binding	7/749	135/18367	0.312811835978297	0.674080891048333	GLDC/SLC19A1/NR2F2/FOLR1/S100A9/P3H1/HBA2	7
GO:0004843	thiol-dependent deubiquitinase	6/749	113/18367	0.313952773371597	0.674080891048333	USP9X/USP27X/USP22/USP48/USP10/EIF3F	6
GO:0003785	actin monomer binding	2/749	28/18367	0.317324142794576	0.674080891048333	PFN1/TMSB4X	2
GO:0004629	phospholipase C activity	2/749	28/18367	0.317324142794576	0.674080891048333	PDIA3/NOTUM	2
GO:0008187	poly-pyrimidine tract binding	2/749	28/18367	0.317324142794576	0.674080891048333	HNRNPC/SSB	2
GO:0015101	organic cation transmembrane transporter activity	2/749	28/18367	0.317324142794576	0.674080891048333	SLC44A2/SLC19A3	2
GO:0019212	phosphatase inhibitor activity	3/749	49/18367	0.322772028837878	0.674080891048333	BOD1L1/PPP1R10/PHACTR2	3
GO:0031491	nucleosome binding	4/749	71/18367	0.328747581445413	0.674080891048333	ARID1A/HP1BP3/HNRNPC/HMGN3	4
GO:0072341	modified amino acid binding	5/749	93/18367	0.329697560576183	0.674080891048333	SLC19A1/MME/FOLR1/SYT7/TLN1	5
GO:0015301	anion:anion antiporter activity	2/749	29/18367	0.3324670593201	0.674080891048333	SLC26A2/SLC19A1	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/749	29/18367	0.3324670593201	0.674080891048333	DHCR24/BLVRA	2
GO:0032452	histone demethylase activity	2/749	29/18367	0.3324670593201	0.674080891048333	KDM5A/KDM5B	2
GO:0140457	protein demethylase activity	2/749	29/18367	0.3324670593201	0.674080891048333	KDM5A/KDM5B	2
GO:0000993	RNA polymerase II complex binding	3/749	50/18367	0.33405650364585	0.674080891048333	BRD4/NCOA3/RTF1	3
GO:0005048	signal sequence binding	3/749	50/18367	0.33405650364585	0.674080891048333	SEC61A1/NFKBIA/KPNB1	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3/749	50/18367	0.33405650364585	0.674080891048333	SLC19A1/SLC25A36/SLC35B4	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/749	50/18367	0.33405650364585	0.674080891048333	CCNL1/CKS1B/CCNE1	3
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	4/749	72/18367	0.33808193356659	0.674080891048333	COX6A1/NDUFB9/UQCRH/COX5A	4
GO:0030276	clathrin binding	4/749	72/18367	0.33808193356659	0.674080891048333	LRP1/SYT7/CLTC/CLTA	4
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/749	10/18367	0.340615787551532	0.674080891048333	RAD50	1
GO:0004300	enoyl-CoA hydratase activity	1/749	10/18367	0.340615787551532	0.674080891048333	HADHA	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/749	10/18367	0.340615787551532	0.674080891048333	AKAP13	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/749	10/18367	0.340615787551532	0.674080891048333	PTPN12	1
GO:0004955	prostaglandin receptor activity	1/749	10/18367	0.340615787551532	0.674080891048333	HPGD	1
GO:0005384	manganese ion transmembrane transporter activity	1/749	10/18367	0.340615787551532	0.674080891048333	TMEM165	1
GO:0005432	calcium:sodium antiporter activity	1/749	10/18367	0.340615787551532	0.674080891048333	SLC3A2	1
GO:0005522	profilin binding	1/749	10/18367	0.340615787551532	0.674080891048333	ACTG1	1
GO:0008172	S-methyltransferase activity	1/749	10/18367	0.340615787551532	0.674080891048333	MTR	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/749	10/18367	0.340615787551532	0.674080891048333	SLC35B4	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/749	10/18367	0.340615787551532	0.674080891048333	SLC3A2	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/749	10/18367	0.340615787551532	0.674080891048333	POR	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/749	10/18367	0.340615787551532	0.674080891048333	DEGS1	1
GO:0019531	oxalate transmembrane transporter activity	1/749	10/18367	0.340615787551532	0.674080891048333	SLC26A2	1
GO:0030957	Tat protein binding	1/749	10/18367	0.340615787551532	0.674080891048333	NPM1	1
GO:0031419	cobalamin binding	1/749	10/18367	0.340615787551532	0.674080891048333	MTR	1
GO:0031720	haptoglobin binding	1/749	10/18367	0.340615787551532	0.674080891048333	HBA2	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/749	10/18367	0.340615787551532	0.674080891048333	SLC27A2	1
GO:0034511	U3 snoRNA binding	1/749	10/18367	0.340615787551532	0.674080891048333	PRKDC	1
GO:0035612	AP-2 adaptor complex binding	1/749	10/18367	0.340615787551532	0.674080891048333	AAK1	1
GO:0043208	glycosphingolipid binding	1/749	10/18367	0.340615787551532	0.674080891048333	PSAP	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/749	10/18367	0.340615787551532	0.674080891048333	ASH1L	1
GO:0050786	RAGE receptor binding	1/749	10/18367	0.340615787551532	0.674080891048333	S100A9	1
GO:0070016	armadillo repeat domain binding	1/749	10/18367	0.340615787551532	0.674080891048333	TCF7L2	1
GO:0070567	cytidylyltransferase activity	1/749	10/18367	0.340615787551532	0.674080891048333	CDS1	1
GO:0097027	ubiquitin-protein transferase activator activity	1/749	10/18367	0.340615787551532	0.674080891048333	UBE2L3	1
GO:0098505	G-rich strand telomeric DNA binding	1/749	10/18367	0.340615787551532	0.674080891048333	HNRNPA1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/749	10/18367	0.340615787551532	0.674080891048333	ADRB1	1
GO:0030695	GTPase regulator activity	22/749	488/18367	0.344615436443163	0.674080891048333	JUN/IQGAP2/MYCBP2/IQGAP1/HACD3/NRP1/ARHGAP21/HERC2/NF1/EEF1B2/ADRB1/AKAP13/RANBP2/RASA1/NUCB1/GNAQ/SYDE2/RABGAP1/ARHGAP5/DOCK8/EPS8L1/RANBP1	22
GO:0060589	nucleoside-triphosphatase regulator activity	22/749	488/18367	0.344615436443163	0.674080891048333	JUN/IQGAP2/MYCBP2/IQGAP1/HACD3/NRP1/ARHGAP21/HERC2/NF1/EEF1B2/ADRB1/AKAP13/RANBP2/RASA1/NUCB1/GNAQ/SYDE2/RABGAP1/ARHGAP5/DOCK8/EPS8L1/RANBP1	22
GO:0033293	monocarboxylic acid binding	4/749	73/18367	0.347425491710154	0.674080891048333	PSAP/NR2F2/S100A9/PYGL	4
GO:0035064	methylated histone binding	4/749	73/18367	0.347425491710154	0.674080891048333	BPTF/ATRX/MPHOSPH8/KDM5A	4
GO:0106306	protein serine phosphatase activity	4/749	73/18367	0.347425491710154	0.674080891048333	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0106307	protein threonine phosphatase activity	4/749	73/18367	0.347425491710154	0.674080891048333	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0140034	methylation-dependent protein binding	4/749	73/18367	0.347425491710154	0.674080891048333	BPTF/ATRX/MPHOSPH8/KDM5A	4
GO:0005343	organic acid:sodium symporter activity	2/749	30/18367	0.347511916006089	0.674080891048333	SLC38A1/SLC38A2	2
GO:0017147	Wnt-protein binding	2/749	30/18367	0.347511916006089	0.674080891048333	WLS/LRP5	2
GO:0005543	phospholipid binding	21/749	466/18367	0.350097631711774	0.674080891048333	PSAP/IQGAP2/IQGAP1/ANXA5/EEA1/MME/PFN1/SPTBN1/ANXA1/SLC9A1/NF1/GPAA1/SYT7/VAMP2/PLEKHA5/VDAC1/TLN1/ANXA4/ANXA3/VDAC2/SDCBP	21
GO:0004879	nuclear receptor activity	3/749	52/18367	0.356590592041364	0.674080891048333	NR2F2/ESRRA/NR2F6	3
GO:0017046	peptide hormone binding	3/749	52/18367	0.356590592041364	0.674080891048333	IGF1R/PRLR/SLC40A1	3
GO:0098531	ligand-activated transcription factor activity	3/749	52/18367	0.356590592041364	0.674080891048333	NR2F2/ESRRA/NR2F6	3
GO:0005254	chloride channel activity	4/749	74/18367	0.356772676138994	0.674080891048333	CLDN4/GABRE/CLIC3/FXYD3	4
GO:0019001	guanyl nucleotide binding	18/749	398/18367	0.359896218212061	0.674080891048333	EEF1A1/RHOB/SLC19A1/GNAQ/IFT27/GNA12/ARHGAP5/TUFM/ARL4A/RAN/RHOBTB3/CDC42/TGM2/TUBA1C/RHOA/TUBA1B/RAB11A/TUBB4B	18
GO:0032561	guanyl ribonucleotide binding	18/749	398/18367	0.359896218212061	0.674080891048333	EEF1A1/RHOB/SLC19A1/GNAQ/IFT27/GNA12/ARHGAP5/TUFM/ARL4A/RAN/RHOBTB3/CDC42/TGM2/TUBA1C/RHOA/TUBA1B/RAB11A/TUBB4B	18
GO:0015631	tubulin binding	17/749	375/18367	0.361958030449513	0.674080891048333	GAPDH/DAG1/ALDOA/MACF1/CLIP1/GJA1/DST/TPR/HOOK2/KIF5B/CEP350/S100A9/GPAA1/RABGAP1/RAB11A/CNN3/CACYBP	17
GO:0008157	protein phosphatase 1 binding	2/749	31/18367	0.362441539874161	0.674080891048333	PPP1R15A/PPP1R9A	2
GO:0016878	acid-thiol ligase activity	2/749	31/18367	0.362441539874161	0.674080891048333	ACSS1/SLC27A2	2
GO:0042910	xenobiotic transmembrane transporter activity	2/749	31/18367	0.362441539874161	0.674080891048333	SLC2A1/SLC19A1	2
GO:0140142	nucleocytoplasmic carrier activity	2/749	31/18367	0.362441539874161	0.674080891048333	KPNB1/RAN	2
GO:0004954	prostanoid receptor activity	1/749	11/18367	0.367519899068877	0.674080891048333	HPGD	1
GO:0005049	nuclear export signal receptor activity	1/749	11/18367	0.367519899068877	0.674080891048333	RAN	1
GO:0008199	ferric iron binding	1/749	11/18367	0.367519899068877	0.674080891048333	FTH1	1
GO:0008503	benzodiazepine receptor activity	1/749	11/18367	0.367519899068877	0.674080891048333	GABRE	1
GO:0010485	H4 histone acetyltransferase activity	1/749	11/18367	0.367519899068877	0.674080891048333	USP22	1
GO:0015368	calcium:cation antiporter activity	1/749	11/18367	0.367519899068877	0.674080891048333	SLC3A2	1
GO:0015378	sodium:chloride symporter activity	1/749	11/18367	0.367519899068877	0.674080891048333	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/749	11/18367	0.367519899068877	0.674080891048333	SLC9A1	1
GO:0016832	aldehyde-lyase activity	1/749	11/18367	0.367519899068877	0.674080891048333	ALDOA	1
GO:0019107	myristoyltransferase activity	1/749	11/18367	0.367519899068877	0.674080891048333	NMT1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/749	11/18367	0.367519899068877	0.674080891048333	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/749	11/18367	0.367519899068877	0.674080891048333	DLG1	1
GO:0031996	thioesterase binding	1/749	11/18367	0.367519899068877	0.674080891048333	CDC42	1
GO:0032052	bile acid binding	1/749	11/18367	0.367519899068877	0.674080891048333	PYGL	1
GO:0035252	UDP-xylosyltransferase activity	1/749	11/18367	0.367519899068877	0.674080891048333	GXYLT1	1
GO:0035673	oligopeptide transmembrane transporter activity	1/749	11/18367	0.367519899068877	0.674080891048333	GJA1	1
GO:0042285	xylosyltransferase activity	1/749	11/18367	0.367519899068877	0.674080891048333	GXYLT1	1
GO:0042608	T cell receptor binding	1/749	11/18367	0.367519899068877	0.674080891048333	EPS8L1	1
GO:0043560	insulin receptor substrate binding	1/749	11/18367	0.367519899068877	0.674080891048333	IGF1R	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/749	11/18367	0.367519899068877	0.674080891048333	TXN	1
GO:0047676	arachidonate-CoA ligase activity	1/749	11/18367	0.367519899068877	0.674080891048333	SLC27A2	1
GO:0061665	SUMO ligase activity	1/749	11/18367	0.367519899068877	0.674080891048333	RANBP2	1
GO:0097371	MDM2/MDM4 family protein binding	1/749	11/18367	0.367519899068877	0.674080891048333	RPS20	1
GO:1901474	azole transmembrane transporter activity	1/749	11/18367	0.367519899068877	0.674080891048333	SLC19A3	1
GO:1901612	cardiolipin binding	1/749	11/18367	0.367519899068877	0.674080891048333	MME	1
GO:1990459	transferrin receptor binding	1/749	11/18367	0.367519899068877	0.674080891048333	CD81	1
GO:0050661	NADP binding	3/749	53/18367	0.367822174074928	0.674080891048333	GAPDH/POR/HSD17B1	3
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/749	53/18367	0.367822174074928	0.674080891048333	SLC6A4/SLC5A3/SLC16A1	3
GO:0005525	GTP binding	17/749	377/18367	0.370175704500282	0.676959797870495	EEF1A1/RHOB/GNAQ/IFT27/GNA12/ARHGAP5/TUFM/ARL4A/RAN/RHOBTB3/CDC42/TGM2/TUBA1C/RHOA/TUBA1B/RAB11A/TUBB4B	17
GO:0008236	serine-type peptidase activity	9/749	191/18367	0.377188321872536	0.682662918257841	CTSC/CTSV/DPP4/CTSA/PRSS8/CPD/CPVL/ST14/MBTPS1	9
GO:0001223	transcription coactivator binding	2/749	32/18367	0.377240317834969	0.682662918257841	RPL23/EPAS1	2
GO:0008378	galactosyltransferase activity	2/749	32/18367	0.377240317834969	0.682662918257841	C1GALT1/C1GALT1C1	2
GO:0015605	organophosphate ester transmembrane transporter activity	2/749	32/18367	0.377240317834969	0.682662918257841	SLC19A1/SLC25A36	2
GO:0031624	ubiquitin conjugating enzyme binding	2/749	32/18367	0.377240317834969	0.682662918257841	SIAH2/SIAH1	2
GO:0003724	RNA helicase activity	4/749	77/18367	0.384782414796765	0.683189642030034	DDX17/DDX46/DHX36/DDX5	4
GO:0019956	chemokine binding	2/749	33/18367	0.39189409831262	0.683189642030034	ITGAV/ITGB1	2
GO:0140323	solute:anion antiporter activity	2/749	33/18367	0.39189409831262	0.683189642030034	SLC26A2/SLC19A1	2
GO:0000340	RNA 7-methylguanosine cap binding	1/749	12/18367	0.393327678301684	0.683189642030034	LARP1	1
GO:0003964	RNA-directed DNA polymerase activity	1/749	12/18367	0.393327678301684	0.683189642030034	PTGES3	1
GO:0003995	acyl-CoA dehydrogenase activity	1/749	12/18367	0.393327678301684	0.683189642030034	ACADVL	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/749	12/18367	0.393327678301684	0.683189642030034	SLC35B4	1
GO:0008429	phosphatidylethanolamine binding	1/749	12/18367	0.393327678301684	0.683189642030034	NF1	1
GO:0015166	polyol transmembrane transporter activity	1/749	12/18367	0.393327678301684	0.683189642030034	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/749	12/18367	0.393327678301684	0.683189642030034	KCNN4	1
GO:0022858	alanine transmembrane transporter activity	1/749	12/18367	0.393327678301684	0.683189642030034	SLC3A2	1
GO:0035256	G protein-coupled glutamate receptor binding	1/749	12/18367	0.393327678301684	0.683189642030034	CALM1	1
GO:0035325	Toll-like receptor binding	1/749	12/18367	0.393327678301684	0.683189642030034	S100A9	1
GO:0042975	peroxisome proliferator activated receptor binding	1/749	12/18367	0.393327678301684	0.683189642030034	HMGA1	1
GO:0043176	amine binding	1/749	12/18367	0.393327678301684	0.683189642030034	SLC6A4	1
GO:0043422	protein kinase B binding	1/749	12/18367	0.393327678301684	0.683189642030034	SRSF5	1
GO:0046790	virion binding	1/749	12/18367	0.393327678301684	0.683189642030034	PPIA	1
GO:0051378	serotonin binding	1/749	12/18367	0.393327678301684	0.683189642030034	SLC6A4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/749	12/18367	0.393327678301684	0.683189642030034	USP27X	1
GO:0070410	co-SMAD binding	1/749	12/18367	0.393327678301684	0.683189642030034	USP9X	1
GO:0017171	serine hydrolase activity	9/749	195/18367	0.400527487550141	0.686228534652102	CTSC/CTSV/DPP4/CTSA/PRSS8/CPD/CPVL/ST14/MBTPS1	9
GO:0042054	histone methyltransferase activity	3/749	56/18367	0.401275287325427	0.686228534652102	KMT2C/ASH1L/NSD1	3
GO:0008186	ATP-dependent activity, acting on RNA	4/749	79/18367	0.403378164985675	0.686228534652102	DDX17/DDX46/DHX36/DDX5	4
GO:0016835	carbon-oxygen lyase activity	4/749	79/18367	0.403378164985675	0.686228534652102	HACD3/TPI1/ENO1/HADHA	4
GO:0004842	ubiquitin-protein transferase activity	19/749	433/18367	0.404614042986035	0.686228534652102	MYCBP2/NHLRC3/RNF43/TTC3/HERC2/ZNRF3/LMO7/TRIM44/RBBP6/HECTD1/RNF13/KLHL42/HUWE1/SIAH2/SIAH1/CDC42/ANAPC11/UBE2L3/UBE2C	19
GO:0016829	lyase activity	9/749	196/18367	0.406370168458682	0.686228534652102	ALDOA/GLDC/MGST3/APMAP/HACD3/TPI1/ENO1/PISD/HADHA	9
GO:0008242	omega peptidase activity	6/749	126/18367	0.408824295451275	0.686228534652102	USP9X/USP27X/USP22/USP48/USP10/EIF3F	6
GO:0043175	RNA polymerase core enzyme binding	3/749	57/18367	0.412320359020813	0.686228534652102	BRD4/NCOA3/RTF1	3
GO:0140677	molecular function activator activity	7/749	150/18367	0.412897242242778	0.686228534652102	PSAP/DDOST/MMP15/CTSA/CALM1/DNAJB1/CALM2	7
GO:0002161	aminoacyl-tRNA editing activity	1/749	13/18367	0.418083743077061	0.686228534652102	IARS2	1
GO:0004000	adenosine deaminase activity	1/749	13/18367	0.418083743077061	0.686228534652102	ADAR	1
GO:0008195	phosphatidate phosphatase activity	1/749	13/18367	0.418083743077061	0.686228534652102	PLPP3	1
GO:0008417	fucosyltransferase activity	1/749	13/18367	0.418083743077061	0.686228534652102	FUT8	1
GO:0008494	translation activator activity	1/749	13/18367	0.418083743077061	0.686228534652102	LARP1	1
GO:0015385	sodium:proton antiporter activity	1/749	13/18367	0.418083743077061	0.686228534652102	SLC9A1	1
GO:0016594	glycine binding	1/749	13/18367	0.418083743077061	0.686228534652102	GLDC	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/749	13/18367	0.418083743077061	0.686228534652102	TXN	1
GO:0016840	carbon-nitrogen lyase activity	1/749	13/18367	0.418083743077061	0.686228534652102	APMAP	1
GO:0022851	GABA-gated chloride ion channel activity	1/749	13/18367	0.418083743077061	0.686228534652102	GABRE	1
GO:0031386	protein tag	1/749	13/18367	0.418083743077061	0.686228534652102	UBA52	1
GO:0031404	chloride ion binding	1/749	13/18367	0.418083743077061	0.686228534652102	CTSC	1
GO:0032036	myosin heavy chain binding	1/749	13/18367	0.418083743077061	0.686228534652102	MYL12B	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/749	13/18367	0.418083743077061	0.686228534652102	ANAPC11	1
GO:0045159	myosin II binding	1/749	13/18367	0.418083743077061	0.686228534652102	TRIOBP	1
GO:0051011	microtubule minus-end binding	1/749	13/18367	0.418083743077061	0.686228534652102	MACF1	1
GO:0061133	endopeptidase activator activity	1/749	13/18367	0.418083743077061	0.686228534652102	PSME2	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/749	13/18367	0.418083743077061	0.686228534652102	CKS1B	1
GO:0070700	BMP receptor binding	1/749	13/18367	0.418083743077061	0.686228534652102	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/749	13/18367	0.418083743077061	0.686228534652102	HSD17B1	1
GO:0004620	phospholipase activity	5/749	104/18367	0.419222052629562	0.686641595005405	PDIA3/PLD3/PLBD1/PRDX6/NOTUM	5
GO:0015298	solute:cation antiporter activity	2/749	35/18367	0.420716815436837	0.686641595005405	SLC3A2/SLC9A1	2
GO:0042887	amide transmembrane transporter activity	2/749	35/18367	0.420716815436837	0.686641595005405	GJA1/SLC19A1	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/749	58/18367	0.423300699061221	0.689557635947187	SLC27A2/SLC16A12/SLC16A1	3
GO:0031406	carboxylic acid binding	8/749	176/18367	0.428305126474124	0.696398372932551	PSAP/GLDC/SLC19A1/NR2F2/FOLR1/S100A9/P3H1/PYGL	8
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	4/749	82/18367	0.431060941774912	0.699564192561536	PFN1/SLC9A1/SYT7/SDCBP	4
GO:0016279	protein-lysine N-methyltransferase activity	3/749	59/18367	0.434209821919926	0.701005389184139	KMT2C/ASH1L/NSD1	3
GO:0042805	actinin binding	2/749	36/18367	0.434863945240935	0.701005389184139	DAG1/PDLIM2	2
GO:0061631	ubiquitin conjugating enzyme activity	2/749	36/18367	0.434863945240935	0.701005389184139	UBE2L3/UBE2C	2
GO:0015078	proton transmembrane transporter activity	6/749	130/18367	0.438005112265677	0.701005389184139	COX6A1/SLC9A1/ATP6V1B1/ATP6V0B/UQCRH/COX5A	6
GO:0017124	SH3 domain binding	6/749	130/18367	0.438005112265677	0.701005389184139	LRP2/GJA1/PTPN12/WASF2/FUT8/GPX1	6
GO:0005344	oxygen carrier activity	1/749	14/18367	0.441830897726472	0.701005389184139	HBA2	1
GO:0005451	monovalent cation:proton antiporter activity	1/749	14/18367	0.441830897726472	0.701005389184139	SLC9A1	1
GO:0015562	efflux transmembrane transporter activity	1/749	14/18367	0.441830897726472	0.701005389184139	GJA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/749	14/18367	0.441830897726472	0.701005389184139	MIF	1
GO:0036041	long-chain fatty acid binding	1/749	14/18367	0.441830897726472	0.701005389184139	S100A9	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/749	14/18367	0.441830897726472	0.701005389184139	HSD17B1	1
GO:1902936	phosphatidylinositol bisphosphate binding	5/749	107/18367	0.44342105119344	0.701005389184139	PFN1/SLC9A1/SYT7/PLEKHA5/SDCBP	5
GO:0001786	phosphatidylserine binding	3/749	60/18367	0.445041607586464	0.701005389184139	MME/SYT7/TLN1	3
GO:0016278	lysine N-methyltransferase activity	3/749	60/18367	0.445041607586464	0.701005389184139	KMT2C/ASH1L/NSD1	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/749	60/18367	0.445041607586464	0.701005389184139	DHCR24/ACADVL/BLVRA	3
GO:0016791	phosphatase activity	12/749	275/18367	0.446989232273618	0.701005389184139	DUSP1/DUSP6/PLPP3/PTPRF/DLG1/PTPRA/PTPN12/DUSP9/ATP1A1/CTDSPL/PTPN14/PHPT1	12
GO:0043531	ADP binding	2/749	37/18367	0.448822302585805	0.701005389184139	MYH10/ATP1A1	2
GO:0001540	amyloid-beta binding	4/749	84/18367	0.44932494560266	0.701005389184139	LRP1/LRPAP1/ITM2B/CST3	4
GO:0005507	copper ion binding	3/749	61/18367	0.455790293585042	0.701005389184139	F5/SOD3/GPC1	3
GO:0050660	flavin adenine dinucleotide binding	4/749	85/18367	0.458387538778693	0.701005389184139	DHCR24/POR/ACADVL/ETFA	4
GO:0015399	primary active transmembrane transporter activity	8/749	181/18367	0.459298757356982	0.701005389184139	ATP2B1/SLC26A2/COX6A1/ATP2B4/ATP1A1/NDUFB9/UQCRH/COX5A	8
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/749	38/18367	0.462583747842837	0.701005389184139	SIAH2/SIAH1	2
GO:0004467	long-chain fatty acid-CoA ligase activity	1/749	15/18367	0.464610206700638	0.701005389184139	SLC27A2	1
GO:0004953	icosanoid receptor activity	1/749	15/18367	0.464610206700638	0.701005389184139	HPGD	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/749	15/18367	0.464610206700638	0.701005389184139	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/749	15/18367	0.464610206700638	0.701005389184139	SLC22A11	1
GO:0005545	1-phosphatidylinositol binding	1/749	15/18367	0.464610206700638	0.701005389184139	EEA1	1
GO:0016805	dipeptidase activity	1/749	15/18367	0.464610206700638	0.701005389184139	CPQ	1
GO:0016846	carbon-sulfur lyase activity	1/749	15/18367	0.464610206700638	0.701005389184139	MGST3	1
GO:0032794	GTPase activating protein binding	1/749	15/18367	0.464610206700638	0.701005389184139	CDH1	1
GO:0042043	neurexin family protein binding	1/749	15/18367	0.464610206700638	0.701005389184139	SDCBP	1
GO:0042813	Wnt-activated receptor activity	1/749	15/18367	0.464610206700638	0.701005389184139	LRP5	1
GO:0048185	activin binding	1/749	15/18367	0.464610206700638	0.701005389184139	TGFBR3	1
GO:0051139	metal ion:proton antiporter activity	1/749	15/18367	0.464610206700638	0.701005389184139	SLC9A1	1
GO:0051371	muscle alpha-actinin binding	1/749	15/18367	0.464610206700638	0.701005389184139	PDLIM2	1
GO:0070742	C2H2 zinc finger domain binding	1/749	15/18367	0.464610206700638	0.701005389184139	SRRM2	1
GO:1901611	phosphatidylglycerol binding	1/749	15/18367	0.464610206700638	0.701005389184139	MME	1
GO:1904680	peptide transmembrane transporter activity	1/749	15/18367	0.464610206700638	0.701005389184139	GJA1	1
GO:1990825	sequence-specific mRNA binding	1/749	15/18367	0.464610206700638	0.701005389184139	SSB	1
GO:0000149	SNARE binding	5/749	110/18367	0.467367805492073	0.701005389184139	TMED9/SLC6A4/SYT7/VAMP2/RAB11A	5
GO:0015085	calcium ion transmembrane transporter activity	6/749	135/18367	0.474078365672749	0.701005389184139	ATP2B1/ITGAV/SLC3A2/ATP2B4/TMEM165/SEC61A1	6
GO:0032182	ubiquitin-like protein binding	5/749	111/18367	0.475281180458698	0.701005389184139	HERC2/N4BP2/FAF2/HSPB1/CKS1B	5
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/749	39/18367	0.47614111706772	0.701005389184139	POLR2J3/POLR2A	2
GO:0004402	histone acetyltransferase activity	2/749	39/18367	0.47614111706772	0.701005389184139	NCOA3/USP22	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/749	39/18367	0.47614111706772	0.701005389184139	IQGAP2/IQGAP1	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/749	39/18367	0.47614111706772	0.701005389184139	DLG1/NME3	2
GO:0019825	oxygen binding	2/749	39/18367	0.47614111706772	0.701005389184139	HBA2/CYP19A1	2
GO:0032451	demethylase activity	2/749	39/18367	0.47614111706772	0.701005389184139	KDM5A/KDM5B	2
GO:0008276	protein methyltransferase activity	4/749	88/18367	0.48525376410995	0.701005389184139	KMT2C/ASH1L/NSD1/LCMT1	4
GO:0004698	calcium-dependent protein kinase C activity	1/749	16/18367	0.486461065200051	0.701005389184139	PKN2	1
GO:0005092	GDP-dissociation inhibitor activity	1/749	16/18367	0.486461065200051	0.701005389184139	RANBP1	1
GO:0005159	insulin-like growth factor receptor binding	1/749	16/18367	0.486461065200051	0.701005389184139	IGF2	1
GO:0005402	carbohydrate:cation symporter activity	1/749	16/18367	0.486461065200051	0.701005389184139	SLC5A3	1
GO:0008191	metalloendopeptidase inhibitor activity	1/749	16/18367	0.486461065200051	0.701005389184139	TIMP3	1
GO:0010181	FMN binding	1/749	16/18367	0.486461065200051	0.701005389184139	POR	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/749	16/18367	0.486461065200051	0.701005389184139	SLC1A5	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/749	16/18367	0.486461065200051	0.701005389184139	SLC22A11	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/749	16/18367	0.486461065200051	0.701005389184139	SLC1A5	1
GO:0017070	U6 snRNA binding	1/749	16/18367	0.486461065200051	0.701005389184139	EIF5A	1
GO:0022821	potassium ion antiporter activity	1/749	16/18367	0.486461065200051	0.701005389184139	SLC9A1	1
GO:0032183	SUMO binding	1/749	16/18367	0.486461065200051	0.701005389184139	HERC2	1
GO:0035173	histone kinase activity	1/749	16/18367	0.486461065200051	0.701005389184139	BAZ1B	1
GO:0042577	lipid phosphatase activity	1/749	16/18367	0.486461065200051	0.701005389184139	PLPP3	1
GO:0070492	oligosaccharide binding	1/749	16/18367	0.486461065200051	0.701005389184139	CHID1	1
GO:0140327	flippase activity	1/749	16/18367	0.486461065200051	0.701005389184139	ATP10D	1
GO:1990404	protein ADP-ribosylase activity	1/749	16/18367	0.486461065200051	0.701005389184139	PARP1	1
GO:0016836	hydro-lyase activity	3/749	64/18367	0.487485313434772	0.701005389184139	HACD3/ENO1/HADHA	3
GO:0015144	carbohydrate transmembrane transporter activity	2/749	40/18367	0.489488156147075	0.701005389184139	SLC2A1/SLC5A3	2
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/749	40/18367	0.489488156147075	0.701005389184139	CYP2J2/CYP19A1	2
GO:0031492	nucleosomal DNA binding	2/749	40/18367	0.489488156147075	0.701005389184139	HNRNPC/HMGN3	2
GO:0042169	SH2 domain binding	2/749	40/18367	0.489488156147075	0.701005389184139	DAG1/ARHGAP5	2
GO:0015297	antiporter activity	4/749	89/18367	0.494090705277481	0.704099604719968	SLC26A2/SLC3A2/SLC19A1/SLC9A1	4
GO:0043178	alcohol binding	4/749	89/18367	0.494090705277481	0.704099604719968	CAV1/CD81/VDAC1/VDAC2	4
GO:0051117	ATPase binding	4/749	89/18367	0.494090705277481	0.704099604719968	EGFR/CAV1/NCSTN/DNAJB1	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/749	41/18367	0.502619458681801	0.704525515095934	ACSS1/SLC27A2	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/749	41/18367	0.502619458681801	0.704525515095934	COL14A1/COL4A2	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/749	41/18367	0.502619458681801	0.704525515095934	NCOA3/USP22	2
GO:0004697	protein kinase C activity	1/749	17/18367	0.507421266941927	0.704525515095934	PKN2	1
GO:0005005	transmembrane-ephrin receptor activity	1/749	17/18367	0.507421266941927	0.704525515095934	EPHB4	1
GO:0008392	arachidonic acid epoxygenase activity	1/749	17/18367	0.507421266941927	0.704525515095934	CYP2J2	1
GO:0008484	sulfuric ester hydrolase activity	1/749	17/18367	0.507421266941927	0.704525515095934	GNS	1
GO:0008574	plus-end-directed microtubule motor activity	1/749	17/18367	0.507421266941927	0.704525515095934	KIF5B	1
GO:0015095	magnesium ion transmembrane transporter activity	1/749	17/18367	0.507421266941927	0.704525515095934	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/749	17/18367	0.507421266941927	0.704525515095934	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/749	17/18367	0.507421266941927	0.704525515095934	SLC38A9	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/749	17/18367	0.507421266941927	0.704525515095934	FTH1	1
GO:0030169	low-density lipoprotein particle binding	1/749	17/18367	0.507421266941927	0.704525515095934	COLEC12	1
GO:0043395	heparan sulfate proteoglycan binding	1/749	17/18367	0.507421266941927	0.704525515095934	LRP1	1
GO:0050780	dopamine receptor binding	1/749	17/18367	0.507421266941927	0.704525515095934	GNA12	1
GO:0070628	proteasome binding	1/749	17/18367	0.507421266941927	0.704525515095934	ID1	1
GO:0019894	kinesin binding	2/749	42/18367	0.515530407412532	0.714637503865129	KTN1/NEK6	2
GO:0070851	growth factor receptor binding	6/749	141/18367	0.516436718224433	0.714748418022615	EFEMP1/APP/IL6ST/NCSTN/GATA3/SDCBP	6
GO:0043130	ubiquitin binding	4/749	92/18367	0.520203058093705	0.716156438772616	N4BP2/FAF2/HSPB1/CKS1B	4
GO:0000295	adenine nucleotide transmembrane transporter activity	1/749	18/18367	0.527527069179556	0.716156438772616	SLC19A1	1
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/749	18/18367	0.527527069179556	0.716156438772616	HSD17B1	1
GO:0004550	nucleoside diphosphate kinase activity	1/749	18/18367	0.527527069179556	0.716156438772616	NME3	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/749	18/18367	0.527527069179556	0.716156438772616	SLC19A1	1
GO:0008301	DNA binding, bending	1/749	18/18367	0.527527069179556	0.716156438772616	HMGB3	1
GO:0008409	5'-3' exonuclease activity	1/749	18/18367	0.527527069179556	0.716156438772616	PLD3	1
GO:0008569	minus-end-directed microtubule motor activity	1/749	18/18367	0.527527069179556	0.716156438772616	DYNC1H1	1
GO:0016755	aminoacyltransferase activity	1/749	18/18367	0.527527069179556	0.716156438772616	TGM2	1
GO:0046624	sphingolipid transporter activity	1/749	18/18367	0.527527069179556	0.716156438772616	ATP10D	1
GO:0099095	ligand-gated anion channel activity	1/749	18/18367	0.527527069179556	0.716156438772616	GABRE	1
GO:0034062	5'-3' RNA polymerase activity	2/749	43/18367	0.52821711900223	0.716156438772616	POLR2J3/POLR2A	2
GO:0097747	RNA polymerase activity	2/749	43/18367	0.52821711900223	0.716156438772616	POLR2J3/POLR2A	2
GO:0042578	phosphoric ester hydrolase activity	15/749	366/18367	0.529606325819258	0.716916231351577	PDIA3/DUSP1/DUSP6/PLPP3/PTPRF/PLD3/DLG1/PTPRA/PTPN12/DUSP9/ATP1A1/CTDSPL/PTPN14/NOTUM/PHPT1	15
GO:0016410	N-acyltransferase activity	4/749	94/18367	0.53725185386499	0.723699773640628	NMT1/NCOA3/USP22/TGM2	4
GO:0003777	microtubule motor activity	3/749	69/18367	0.538207772702213	0.723699773640628	DYNC1H1/KIF5B/DYNLRB1	3
GO:0001784	phosphotyrosine residue binding	2/749	44/18367	0.540676392000069	0.723699773640628	PFN1/RASA1	2
GO:0022839	ion gated channel activity	2/749	44/18367	0.540676392000069	0.723699773640628	KCNN4/TMEM63A	2
GO:0051879	Hsp90 protein binding	2/749	44/18367	0.540676392000069	0.723699773640628	KPNB1/PTGES3	2
GO:0001664	G protein-coupled receptor binding	12/749	295/18367	0.54521689618778	0.723699773640628	ITGB4/WLS/RNF43/HSPA1A/ZNRF3/ADRB1/HSPA1B/GNAQ/ADM/GNA12/CALM1/SDCBP	12
GO:0000339	RNA cap binding	1/749	19/18367	0.5468132550853	0.723699773640628	LARP1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/749	19/18367	0.5468132550853	0.723699773640628	GALNT11	1
GO:0004890	GABA-A receptor activity	1/749	19/18367	0.5468132550853	0.723699773640628	GABRE	1
GO:0005003	ephrin receptor activity	1/749	19/18367	0.5468132550853	0.723699773640628	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/749	19/18367	0.5468132550853	0.723699773640628	SLC6A4	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/749	19/18367	0.5468132550853	0.723699773640628	PLEKHA5	1
GO:0030627	pre-mRNA 5'-splice site binding	1/749	19/18367	0.5468132550853	0.723699773640628	SNRPC	1
GO:0035613	RNA stem-loop binding	1/749	19/18367	0.5468132550853	0.723699773640628	MYH10	1
GO:0001098	basal transcription machinery binding	3/749	70/18367	0.548003874837701	0.723699773640628	BRD4/NCOA3/RTF1	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/749	70/18367	0.548003874837701	0.723699773640628	BRD4/NCOA3/RTF1	3
GO:0048156	tau protein binding	2/749	45/18367	0.552905657819545	0.728756948535709	LGMN/ROCK1	2
GO:0052689	carboxylic ester hydrolase activity	6/749	147/18367	0.557420069514274	0.728756948535709	APMAP/IARS2/PGAP1/PON2/PRDX6/NOTUM	6
GO:0005179	hormone activity	5/749	122/18367	0.559277637631362	0.728756948535709	FBN1/CSH1/ADM/IGF2/CGA	5
GO:0004896	cytokine receptor activity	4/749	97/18367	0.562237645250626	0.728756948535709	CSF3R/IL6ST/PRLR/IL10RB	4
GO:1901981	phosphatidylinositol phosphate binding	7/749	173/18367	0.562413123648717	0.728756948535709	IQGAP2/IQGAP1/PFN1/SLC9A1/SYT7/PLEKHA5/SDCBP	7
GO:0019842	vitamin binding	6/749	148/18367	0.564093868276218	0.728756948535709	GLDC/SLC19A1/FOLR1/P3H1/MTR/PYGL	6
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/749	20/18367	0.565313193604001	0.728756948535709	FOS	1
GO:0001972	retinoic acid binding	1/749	20/18367	0.565313193604001	0.728756948535709	NR2F2	1
GO:0016408	C-acyltransferase activity	1/749	20/18367	0.565313193604001	0.728756948535709	HADHA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/749	20/18367	0.565313193604001	0.728756948535709	CTSC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/749	20/18367	0.565313193604001	0.728756948535709	GLDC	1
GO:0030296	protein tyrosine kinase activator activity	1/749	20/18367	0.565313193604001	0.728756948535709	ERBB3	1
GO:0031418	L-ascorbic acid binding	1/749	20/18367	0.565313193604001	0.728756948535709	P3H1	1
GO:0031690	adrenergic receptor binding	1/749	20/18367	0.565313193604001	0.728756948535709	ADRB1	1
GO:0050145	nucleoside monophosphate kinase activity	1/749	20/18367	0.565313193604001	0.728756948535709	DLG1	1
GO:0061608	nuclear import signal receptor activity	1/749	20/18367	0.565313193604001	0.728756948535709	KPNB1	1
GO:0004722	protein serine/threonine phosphatase activity	4/749	98/18367	0.570401209985612	0.734221795591598	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	5/749	124/18367	0.573828047110684	0.737535305721756	LDHA/HADHA/DHRS2/HSD17B1/HPGD	5
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/749	47/18367	0.576666783604745	0.740084225249413	GABRE/ADRB1	2
GO:0001848	complement binding	1/749	21/18367	0.583058896879228	0.743873076401965	CALR	1
GO:0008391	arachidonic acid monooxygenase activity	1/749	21/18367	0.583058896879228	0.743873076401965	CYP2J2	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/749	21/18367	0.583058896879228	0.743873076401965	SLC19A1	1
GO:1990381	ubiquitin-specific protease binding	1/749	21/18367	0.583058896879228	0.743873076401965	CLTC	1
GO:0070888	E-box binding	2/749	48/18367	0.588196268600306	0.749322197848696	GATA3/HES1	2
GO:0140097	catalytic activity, acting on DNA	9/749	229/18367	0.592621235147186	0.753367387776993	BPTF/ATRX/ANXA1/PLD3/CHD2/DHX36/RAD50/SMARCA2/PTGES3	9
GO:0019003	GDP binding	3/749	75/18367	0.595093909389016	0.753367387776993	RHOB/RAN/RHOA	3
GO:0016763	pentosyltransferase activity	2/749	49/18367	0.599490917100834	0.753367387776993	GXYLT1/PARP1	2
GO:0034212	peptide N-acetyltransferase activity	2/749	49/18367	0.599490917100834	0.753367387776993	NCOA3/USP22	2
GO:0015106	bicarbonate transmembrane transporter activity	1/749	22/18367	0.600081075350691	0.753367387776993	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/749	22/18367	0.600081075350691	0.753367387776993	SLC27A2	1
GO:0016917	GABA receptor activity	1/749	22/18367	0.600081075350691	0.753367387776993	GABRE	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/749	22/18367	0.600081075350691	0.753367387776993	SERPINB9	1
GO:0050321	tau-protein kinase activity	1/749	22/18367	0.600081075350691	0.753367387776993	ROCK1	1
GO:0070182	DNA polymerase binding	1/749	22/18367	0.600081075350691	0.753367387776993	PTGES3	1
GO:0016298	lipase activity	5/749	129/18367	0.609065063919192	0.763538087376958	PDIA3/PLD3/PLBD1/PRDX6/NOTUM	5
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	12/749	310/18367	0.614655348049841	0.763888180349276	JUN/NFE2L3/PEG3/ZFHX3/ENO1/IRX2/FOXP1/LRRFIP1/GATA3/NR2F6/HES1/YY1	12
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/749	23/18367	0.616409190617103	0.763888180349276	PARP1	1
GO:0004529	exodeoxyribonuclease activity	1/749	23/18367	0.616409190617103	0.763888180349276	PLD3	1
GO:0005212	structural constituent of eye lens	1/749	23/18367	0.616409190617103	0.763888180349276	CRYBG3	1
GO:0008143	poly(A) binding	1/749	23/18367	0.616409190617103	0.763888180349276	HNRNPDL	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/749	23/18367	0.616409190617103	0.763888180349276	PKN2	1
GO:0015299	solute:proton antiporter activity	1/749	23/18367	0.616409190617103	0.763888180349276	SLC9A1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/749	23/18367	0.616409190617103	0.763888180349276	PLD3	1
GO:0001221	transcription coregulator binding	3/749	78/18367	0.621769014892374	0.768975883015618	RPL23/EPAS1/NEK6	3
GO:0001217	DNA-binding transcription repressor activity	12/749	313/18367	0.627923949710298	0.768975883015618	JUN/NFE2L3/PEG3/ZFHX3/ENO1/IRX2/FOXP1/LRRFIP1/GATA3/NR2F6/HES1/YY1	12
GO:0016779	nucleotidyltransferase activity	5/749	132/18367	0.629378991819201	0.768975883015618	POLR2J3/CDS1/POLR2A/PTGES3/UGP2	5
GO:0016830	carbon-carbon lyase activity	2/749	52/18367	0.631967332261916	0.768975883015618	ALDOA/PISD	2
GO:0001965	G-protein alpha-subunit binding	1/749	24/18367	0.632071506155034	0.768975883015618	NUCB1	1
GO:0003707	steroid hormone receptor activity	1/749	24/18367	0.632071506155034	0.768975883015618	ESRRA	1
GO:0008171	O-methyltransferase activity	1/749	24/18367	0.632071506155034	0.768975883015618	LCMT1	1
GO:0010857	calcium-dependent protein kinase activity	1/749	24/18367	0.632071506155034	0.768975883015618	PKN2	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/749	24/18367	0.632071506155034	0.768975883015618	GAPDH	1
GO:0019789	SUMO transferase activity	1/749	24/18367	0.632071506155034	0.768975883015618	RANBP2	1
GO:0043495	protein-membrane adaptor activity	1/749	24/18367	0.632071506155034	0.768975883015618	SYNE2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/749	24/18367	0.632071506155034	0.768975883015618	BMP7	1
GO:0070840	dynein complex binding	1/749	24/18367	0.632071506155034	0.768975883015618	TPR	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	2/749	53/18367	0.642325965916308	0.780353877131469	SLC19A1/SLC35B4	2
GO:0005160	transforming growth factor beta receptor binding	1/749	25/18367	0.647095135980573	0.781906739440482	TGFBR3	1
GO:0030247	polysaccharide binding	1/749	25/18367	0.647095135980573	0.781906739440482	AGL	1
GO:0070330	aromatase activity	1/749	25/18367	0.647095135980573	0.781906739440482	CYP19A1	1
GO:0035591	signaling adaptor activity	3/749	81/18367	0.647219913802757	0.781906739440482	IQGAP1/DLG5/AKAP13	3
GO:0008374	O-acyltransferase activity	2/749	54/18367	0.652453166022317	0.787129691226365	CROT/PRDX6	2
GO:0042626	ATPase-coupled transmembrane transporter activity	4/749	109/18367	0.654241455243875	0.788187825607176	ATP2B1/SLC26A2/ATP2B4/ATP1A1	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	5/749	136/18367	0.655445981815392	0.788540715257739	LDHA/HADHA/DHRS2/HSD17B1/HPGD	5
GO:0004364	glutathione transferase activity	1/749	26/18367	0.661506091337162	0.791344241137829	GSTO1	1
GO:0038187	pattern recognition receptor activity	1/749	26/18367	0.661506091337162	0.791344241137829	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/749	26/18367	0.661506091337162	0.791344241137829	SLC26A2	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	17/749	450/18367	0.66197949637613	0.791344241137829	JUN/FOS/JUND/FOSB/SOX4/PBX1/EGR1/ISL1/NFAT5/JUNB/CREB3L2/ATF6/GTF2I/DDIT3/GATA3/EPAS1/YY1	17
GO:0030170	pyridoxal phosphate binding	2/749	55/18367	0.662350555588194	0.791344241137829	GLDC/PYGL	2
GO:0008017	microtubule binding	10/749	271/18367	0.671269390260535	0.795858128812586	GAPDH/MACF1/CLIP1/DST/HOOK2/KIF5B/CEP350/S100A9/RAB11A/CNN3	10
GO:0035091	phosphatidylinositol binding	10/749	271/18367	0.671269390260535	0.795858128812586	IQGAP2/IQGAP1/EEA1/PFN1/SLC9A1/GPAA1/SYT7/PLEKHA5/TLN1/SDCBP	10
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/749	56/18367	0.672020009968297	0.795858128812586	CST3/SERPINB9	2
GO:0070279	vitamin B6 binding	2/749	56/18367	0.672020009968297	0.795858128812586	GLDC/PYGL	2
GO:0001671	ATPase activator activity	1/749	27/18367	0.675329325489524	0.795858128812586	DNAJB1	1
GO:0004709	MAP kinase kinase kinase activity	1/749	27/18367	0.675329325489524	0.795858128812586	EGFR	1
GO:0016866	intramolecular transferase activity	1/749	27/18367	0.675329325489524	0.795858128812586	CYP2J2	1
GO:0030507	spectrin binding	1/749	27/18367	0.675329325489524	0.795858128812586	ANK3	1
GO:0043425	bHLH transcription factor binding	1/749	27/18367	0.675329325489524	0.795858128812586	ISL1	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/749	27/18367	0.675329325489524	0.795858128812586	ATP10D	1
GO:0004536	deoxyribonuclease activity	2/749	57/18367	0.681463633639114	0.801994616459638	PLD3/RAD50	2
GO:0001216	DNA-binding transcription activator activity	17/749	456/18367	0.682877910860376	0.802567109910632	JUN/FOS/JUND/FOSB/SOX4/PBX1/EGR1/ISL1/NFAT5/JUNB/CREB3L2/ATF6/GTF2I/DDIT3/GATA3/EPAS1/YY1	17
GO:0003774	cytoskeletal motor activity	4/749	114/18367	0.688516116235019	0.803818207619281	DYNC1H1/MYH10/KIF5B/DYNLRB1	4
GO:0017056	structural constituent of nuclear pore	1/749	28/18367	0.688588776700448	0.803818207619281	TPR	1
GO:0046875	ephrin receptor binding	1/749	28/18367	0.688588776700448	0.803818207619281	SDCBP	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/749	28/18367	0.688588776700448	0.803818207619281	PLEKHA5	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/749	28/18367	0.688588776700448	0.803818207619281	SKP1	1
GO:0005085	guanyl-nucleotide exchange factor activity	8/749	223/18367	0.693449595206023	0.808401482281954	MYCBP2/HERC2/EEF1B2/ADRB1/AKAP13/NUCB1/DOCK8/EPS8L1	8
GO:0004181	metallocarboxypeptidase activity	1/749	29/18367	0.701307409464032	0.811003889286614	CPD	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/749	29/18367	0.701307409464032	0.811003889286614	CDK6	1
GO:0033612	receptor serine/threonine kinase binding	1/749	29/18367	0.701307409464032	0.811003889286614	BMP7	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/749	29/18367	0.701307409464032	0.811003889286614	PLEKHA5	1
GO:0070717	poly-purine tract binding	1/749	29/18367	0.701307409464032	0.811003889286614	HNRNPDL	1
GO:0097472	cyclin-dependent protein kinase activity	1/749	29/18367	0.701307409464032	0.811003889286614	CDK6	1
GO:0008081	phosphoric diester hydrolase activity	3/749	89/18367	0.709027577349283	0.818836921771869	PDIA3/PLD3/NOTUM	3
GO:0004674	protein serine/threonine kinase activity	14/749	386/18367	0.711261854715147	0.82032200577147	EGFR/AAK1/TGFBR3/PRKDC/PKN2/LTBP1/BRD4/CDK6/AKAP13/ROCK1/BRD2/EIF2AK4/NEK6/CSNK2B	14
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/749	30/18367	0.71350725406603	0.821815945096027	HSD17B1	1
GO:0004252	serine-type endopeptidase activity	6/749	174/18367	0.717996021113445	0.825886380669056	CTSC/CTSV/DPP4/PRSS8/ST14/MBTPS1	6
GO:0016407	acetyltransferase activity	3/749	91/18367	0.723110621162402	0.828870377828478	NCOA3/HADHA/USP22	3
GO:0000146	microfilament motor activity	1/749	31/18367	0.725209444539092	0.828870377828478	MYH10	1
GO:0071813	lipoprotein particle binding	1/749	31/18367	0.725209444539092	0.828870377828478	COLEC12	1
GO:0071814	protein-lipid complex binding	1/749	31/18367	0.725209444539092	0.828870377828478	COLEC12	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/749	62/18367	0.725381359556252	0.828870377828478	GABRE/ADRB1	2
GO:0046906	tetrapyrrole binding	5/749	149/18367	0.731740996079142	0.832700170774397	MTR/CYP11A1/CYP2J2/HBA2/CYP19A1	5
GO:0001222	transcription corepressor binding	1/749	32/18367	0.736434255077935	0.832700170774397	NEK6	1
GO:0030332	cyclin binding	1/749	32/18367	0.736434255077935	0.832700170774397	CDK6	1
GO:0030515	snoRNA binding	1/749	32/18367	0.736434255077935	0.832700170774397	PRKDC	1
GO:0048019	receptor antagonist activity	1/749	32/18367	0.736434255077935	0.832700170774397	LRPAP1	1
GO:0050699	WW domain binding	1/749	32/18367	0.736434255077935	0.832700170774397	PRRG4	1
GO:0051721	protein phosphatase 2A binding	1/749	32/18367	0.736434255077935	0.832700170774397	BOD1L1	1
GO:0071889	14-3-3 protein binding	1/749	32/18367	0.736434255077935	0.832700170774397	ZFP36L1	1
GO:0004623	phospholipase A2 activity	1/749	33/18367	0.747201134976851	0.840479820227537	PRDX6	1
GO:0005154	epidermal growth factor receptor binding	1/749	33/18367	0.747201134976851	0.840479820227537	EFEMP1	1
GO:0019239	deaminase activity	1/749	33/18367	0.747201134976851	0.840479820227537	ADAR	1
GO:0051427	hormone receptor binding	1/749	33/18367	0.747201134976851	0.840479820227537	CSH1	1
GO:0016229	steroid dehydrogenase activity	1/749	34/18367	0.757528742149445	0.848785442952422	HSD17B1	1
GO:0016831	carboxy-lyase activity	1/749	34/18367	0.757528742149445	0.848785442952422	PISD	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/749	34/18367	0.757528742149445	0.848785442952422	HSPB1	1
GO:0008170	N-methyltransferase activity	3/749	97/18367	0.762168379443908	0.852879234435939	KMT2C/ASH1L/NSD1	3
GO:0008080	N-acetyltransferase activity	2/749	68/18367	0.771211054440475	0.861883155156345	NCOA3/USP22	2
GO:0005484	SNAP receptor activity	1/749	36/18367	0.776937004717969	0.863818135065608	VAMP2	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/749	36/18367	0.776937004717969	0.863818135065608	ADAR	1
GO:0034061	DNA polymerase activity	1/749	36/18367	0.776937004717969	0.863818135065608	PTGES3	1
GO:0042605	peptide antigen binding	1/749	36/18367	0.776937004717969	0.863818135065608	DHCR24	1
GO:0004860	protein kinase inhibitor activity	2/749	70/18367	0.784935861620047	0.868370850867811	NPM1/HSPB1	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/749	37/18367	0.786051301999418	0.868370850867811	GAPDH	1
GO:0030551	cyclic nucleotide binding	1/749	37/18367	0.786051301999418	0.868370850867811	SLC19A1	1
GO:0042056	chemoattractant activity	1/749	37/18367	0.786051301999418	0.868370850867811	MIF	1
GO:0071949	FAD binding	1/749	37/18367	0.786051301999418	0.868370850867811	DHCR24	1
GO:0004497	monooxygenase activity	3/749	102/18367	0.791198886821616	0.870477274314554	CYP11A1/CYP2J2/CYP19A1	3
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/749	71/18367	0.791523076548019	0.870477274314554	ASAH1/TGM2	2
GO:0004520	endodeoxyribonuclease activity	1/749	38/18367	0.794793668327974	0.870477274314554	RAD50	1
GO:0005501	retinoid binding	1/749	38/18367	0.794793668327974	0.870477274314554	NR2F2	1
GO:0019840	isoprenoid binding	1/749	38/18367	0.794793668327974	0.870477274314554	NR2F2	1
GO:0140303	intramembrane lipid transporter activity	1/749	38/18367	0.794793668327974	0.870477274314554	ATP10D	1
GO:0008083	growth factor activity	5/749	162/18367	0.795002366136992	0.870477274314554	GRN/EFEMP1/CSH1/BMP7/IGF2	5
GO:0031490	chromatin DNA binding	3/749	103/18367	0.796637758210478	0.87116518438946	ACTN4/HNRNPC/HMGN3	3
GO:0000287	magnesium ion binding	7/749	221/18367	0.801651092854237	0.875540650655196	S100P/ENO1/ATP10D/DHX36/PKM/RAN/NEK6	7
GO:0005504	fatty acid binding	1/749	39/18367	0.803179261782191	0.876103482271873	S100A9	1
GO:0016746	acyltransferase activity	8/749	250/18367	0.804298281753157	0.876219160851991	KMT2C/CROT/NMT1/NCOA3/HADHA/USP22/PRDX6/TGM2	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	7/749	222/18367	0.805329239101515	0.876238731852592	CROT/NMT1/NCOA3/HADHA/USP22/PRDX6/TGM2	7
GO:1990782	protein tyrosine kinase binding	3/749	105/18367	0.807160541185026	0.877127975031467	ITGB1/EIF3A/PTPN14	3
GO:0019210	kinase inhibitor activity	2/749	74/18367	0.810226994021716	0.8793327936057	NPM1/HSPB1	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/749	40/18367	0.811222623465143	0.8793327936057	SERPINB9	1
GO:0004812	aminoacyl-tRNA ligase activity	1/749	41/18367	0.818937702584726	0.885476390919736	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/749	41/18367	0.818937702584726	0.885476390919736	IARS2	1
GO:0020037	heme binding	4/749	139/18367	0.823500057857194	0.88929781528898	CYP11A1/CYP2J2/HBA2/CYP19A1	4
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1/749	42/18367	0.826337880515756	0.891249709035073	NDUFB9	1
GO:0030971	receptor tyrosine kinase binding	2/749	78/18367	0.832831700051095	0.894444335869272	EIF3A/PTPN14	2
GO:0030547	signaling receptor inhibitor activity	1/749	43/18367	0.833435993885125	0.894444335869272	LRPAP1	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/749	43/18367	0.833435993885125	0.894444335869272	PLEKHA5	1
GO:0050136	NADH dehydrogenase (quinone) activity	1/749	43/18367	0.833435993885125	0.894444335869272	NDUFB9	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/749	44/18367	0.840244356719661	0.899519020498152	GAPDH	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/749	44/18367	0.840244356719661	0.899519020498152	GABRE	1
GO:0004527	exonuclease activity	2/749	80/18367	0.843198046704794	0.899828238533028	PLD3/RAD50	2
GO:0140375	immune receptor activity	4/749	144/18367	0.843730797526553	0.899828238533028	CSF3R/IL6ST/PRLR/IL10RB	4
GO:0003954	NADH dehydrogenase activity	1/749	45/18367	0.846774781694664	0.899828238533028	NDUFB9	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/749	45/18367	0.846774781694664	0.899828238533028	NDUFB9	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1/749	45/18367	0.846774781694664	0.899828238533028	BAZ1B	1
GO:0005245	voltage-gated calcium channel activity	1/749	45/18367	0.846774781694664	0.899828238533028	ITGAV	1
GO:0140296	general transcription initiation factor binding	1/749	46/18367	0.853038600519612	0.905372256993208	BDP1	1
GO:0008168	methyltransferase activity	6/749	214/18367	0.873415386620757	0.925863124297739	KMT2C/METTL7A/ASH1L/MTR/NSD1/LCMT1	6
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/749	50/18367	0.875638687961628	0.925950446316392	MAN2A1	1
GO:0030159	signaling receptor complex adaptor activity	1/749	50/18367	0.875638687961628	0.925950446316392	DLG5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/749	88/18367	0.87906833549029	0.92761093332024	POR/NDUFB9	2
GO:0008227	G protein-coupled amine receptor activity	1/749	51/18367	0.880723943337331	0.92761093332024	ADRB1	1
GO:0015079	potassium ion transmembrane transporter activity	4/749	155/18367	0.881434770782814	0.92761093332024	KCNN4/SLC12A9/SLC9A1/ATP1A1	4
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	4/749	156/18367	0.884435688877	0.92761093332024	KMT2C/ASH1L/NSD1/LCMT1	4
GO:0008146	sulfotransferase activity	1/749	52/18367	0.885601523946653	0.92761093332024	TPST2	1
GO:0016597	amino acid binding	1/749	52/18367	0.885601523946653	0.92761093332024	GLDC	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/749	52/18367	0.885601523946653	0.92761093332024	AGL	1
GO:0015267	channel activity	15/749	480/18367	0.885788012627189	0.92761093332024	ITGAV/CLDN4/KCNN4/GJA1/GABRE/TMEM150C/GJA5/CLIC3/TMC5/TMEM63A/TMEM109/SEC61A1/VDAC1/FXYD3/VDAC2	15
GO:0022803	passive transmembrane transporter activity	15/749	481/18367	0.887535134106152	0.928316675939325	ITGAV/CLDN4/KCNN4/GJA1/GABRE/TMEM150C/GJA5/CLIC3/TMC5/TMEM63A/TMEM109/SEC61A1/VDAC1/FXYD3/VDAC2	15
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/749	125/18367	0.889199786526678	0.928832302726923	ASAH1/ADAR/TGM2	3
GO:0017069	snRNA binding	1/749	53/18367	0.890279900062621	0.928832302726923	EIF5A	1
GO:0022836	gated channel activity	10/749	340/18367	0.891249492789995	0.928832302726923	ITGAV/KCNN4/GABRE/TMEM150C/CLIC3/TMC5/TMEM63A/TMEM109/VDAC1/VDAC2	10
GO:0008408	3'-5' exonuclease activity	1/749	54/18367	0.894767196931306	0.931376203785294	RAD50	1
GO:0016741	transferase activity, transferring one-carbon groups	6/749	225/18367	0.900785217034778	0.936513476845052	KMT2C/METTL7A/ASH1L/MTR/NSD1/LCMT1	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/749	57/18367	0.907158979901587	0.942007824267554	NDUFB9	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/749	58/18367	0.910956791155203	0.944817295382795	GSTO1	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/749	59/18367	0.914599445774503	0.946544317504415	PLD3	1
GO:0005244	voltage-gated ion channel activity	5/749	201/18367	0.91671545443906	0.946544317504415	ITGAV/CLIC3/TMEM109/VDAC1/VDAC2	5
GO:0022832	voltage-gated channel activity	5/749	201/18367	0.91671545443906	0.946544317504415	ITGAV/CLIC3/TMEM109/VDAC1/VDAC2	5
GO:0022824	transmitter-gated ion channel activity	1/749	60/18367	0.918093274434919	0.946544317504415	GABRE	1
GO:0022835	transmitter-gated channel activity	1/749	60/18367	0.918093274434919	0.946544317504415	GABRE	1
GO:0005126	cytokine receptor binding	7/749	271/18367	0.929081812230757	0.956733056642387	TGFBR3/MIF/IL6ST/CSH1/PRLR/GATA3/SDCBP	7
GO:0030145	manganese ion binding	1/749	65/18367	0.933534120106037	0.960174808432488	EXTL2	1
GO:0005216	ion channel activity	12/749	432/18367	0.940978088512543	0.964787976790229	ITGAV/CLDN4/KCNN4/GABRE/TMEM150C/CLIC3/TMC5/TMEM63A/SEC61A1/VDAC1/FXYD3/VDAC2	12
GO:0003684	damaged DNA binding	1/749	68/18367	0.941365378509773	0.964787976790229	DDB1	1
GO:0016782	transferase activity, transferring sulphur-containing groups	1/749	68/18367	0.941365378509773	0.964787976790229	TPST2	1
GO:0030594	neurotransmitter receptor activity	2/749	111/18367	0.944237508203773	0.966088179870313	GABRE/ADRB1	2
GO:0030546	signaling receptor activator activity	14/749	495/18367	0.944867745861601	0.966088179870313	FBN1/GRN/EFEMP1/APP/SEMA6A/LRPAP1/MIF/SEMA6D/DPP4/CSH1/BMP7/ADM/IGF2/CGA	14
GO:0005230	extracellular ligand-gated ion channel activity	1/749	73/18367	0.952423464508274	0.972388357414423	GABRE	1
GO:0005319	lipid transporter activity	3/749	154/18367	0.953277834783157	0.972388357414423	SLC2A1/SLC27A2/ATP10D	3
GO:0005262	calcium channel activity	2/749	119/18367	0.957728891059701	0.975777963211591	ITGAV/SEC61A1	2
GO:0048018	receptor ligand activity	13/749	487/18367	0.963278743389124	0.980277780037168	FBN1/GRN/EFEMP1/SEMA6A/LRPAP1/MIF/SEMA6D/DPP4/CSH1/BMP7/ADM/IGF2/CGA	13
GO:0016874	ligase activity	3/749	165/18367	0.966821592184737	0.982727000281783	ACSS1/SLC27A2/IARS2	3
GO:0004519	endonuclease activity	2/749	129/18367	0.97023748401815	0.985041577084155	N4BP2/RAD50	2
GO:0008528	G protein-coupled peptide receptor activity	2/749	147/18367	0.98434768584399	0.99819548447251	LGR5/LGR4	2
GO:0001653	peptide receptor activity	2/749	153/18367	0.987400760893787	0.998618948230129	LGR5/LGR4	2
GO:0106310	protein serine kinase activity	7/749	360/18367	0.99213039068578	0.998618948230129	AAK1/PRKDC/PKN2/CDK6/ROCK1/EIF2AK4/NEK6	7
GO:0004518	nuclease activity	3/749	210/18367	0.992330392765312	0.998618948230129	PLD3/N4BP2/RAD50	3
GO:0003823	antigen binding	2/749	171/18367	0.993475659431415	0.998618948230129	DHCR24/TSPAN4	2
GO:0005267	potassium channel activity	1/749	121/18367	0.993620405031182	0.998618948230129	KCNN4	1
GO:0140101	catalytic activity, acting on a tRNA	1/749	124/18367	0.994374283875408	0.998618948230129	IARS2	1
GO:0140098	catalytic activity, acting on RNA	7/749	386/18367	0.996129028070454	0.998618948230129	POLR2J3/IARS2/DDX17/DDX46/POLR2A/DHX36/DDX5	7
GO:0005125	cytokine activity	3/749	235/18367	0.996719097742608	0.998618948230129	GRN/MIF/BMP7	3
GO:0015276	ligand-gated ion channel activity	1/749	143/18367	0.997464475457609	0.998618948230129	GABRE	1
GO:0022834	ligand-gated channel activity	1/749	143/18367	0.997464475457609	0.998618948230129	GABRE	1
GO:0022843	voltage-gated cation channel activity	1/749	143/18367	0.997464475457609	0.998618948230129	ITGAV	1
GO:0005261	cation channel activity	4/749	335/18367	0.999520629922393	0.999520629922393	ITGAV/KCNN4/TMEM63A/SEC61A1	4