ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	29/313	332/18367	5.83863638941322e-13	3.43895683336439e-10	LDHA/ALDOA/FLNB/PKM/EFHD2/EPS8L1/KRT18/ANXA1/ENO1/EIF4H/PFN1/TAGLN2/IDH1/PRDX1/RPL29/PKP3/BSG/EZR/MYH9/CLIC1/STK24/ITGB1/HSPA1A/CTNND1/PPFIBP1/PRDX6/ARGLU1/AHNAK/S100P	29
GO:0097718	disordered domain specific binding	8/313	36/18367	1.29974904006105e-07	3.8277609229798e-05	GAPDH/FN1/EZR/FKBP8/HSPA1A/CALM1/GJA1/AP2A2	8
GO:0005178	integrin binding	12/313	144/18367	6.7738059044408e-06	0.00132992389257188	IGF2/FN1/FBN1/TIMP2/FBLN1/MYH9/CD151/ITGB1/DST/ITGB8/JAM3/FERMT1	12
GO:0048306	calcium-dependent protein binding	9/313	88/18367	1.89679599439056e-05	0.0027930321017401	ANXA4/DDX5/ANXA1/PDCD6/S100A6/S100A10/CALM1/CLN3/S100P	9
GO:0061134	peptidase regulator activity	14/313	230/18367	4.27280148229057e-05	0.00473583450923245	GAPDH/SERPINB9/CAV1/TFPI2/FN1/TIMP2/ITIH5/TIMP3/SERPINB1/SERPINE1/FBLN1/CTSC/PTTG1/BIRC5	14
GO:0140297	DNA-binding transcription factor binding	19/313	394/18367	4.991544609087e-05	0.00473583450923245	ANXA4/NEK6/DDX5/TLE4/FOS/JUN/FUS/SRI/ISL1/CEBPB/HSPB1/PARP1/FHL2/TACC2/ACTB/HMGN3/BHLHE41/ID2/HES1	19
GO:0098631	cell adhesion mediator activity	7/313	59/18367	6.23107965327225e-05	0.00473583450923245	KRT18/ANXA1/DSP/PKP3/BSG/ITGB1/JAM3	7
GO:0140678	molecular function inhibitor activity	10/313	128/18367	6.88748260297612e-05	0.00473583450923245	CAV1/ANXA4/RPL23/DYNLL1/ANXA1/PHPT1/OAZ1/TMBIM6/CALM1/ID2	10
GO:0140666	annealing activity	4/313	14/18367	7.23641945383567e-05	0.00473583450923245	ANXA1/EIF4H/SMARCA1/EIF4B	4
GO:0001968	fibronectin binding	5/313	28/18367	9.91408205347384e-05	0.00583939432949609	PLEKHA2/IGFBP3/CCDC80/FBLN1/ITGB1	5
GO:0008201	heparin binding	11/313	166/18367	0.000133761418276624	0.00716231594226651	FN1/FBN1/NRP2/CCDC80/RPL29/LAMC2/VEGFB/SOD3/PGF/TGFBR3/ADAMTS1	11
GO:0098632	cell-cell adhesion mediator activity	6/313	49/18367	0.000176211344615543	0.00864904016487957	KRT18/ANXA1/DSP/PKP3/BSG/JAM3	6
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	15/313	299/18367	0.000201562484535856	0.00886283693139963	ANXA4/DDX5/FOS/JUN/FUS/ISL1/CEBPB/HSPB1/PARP1/TACC2/ACTB/HMGN3/BHLHE41/ID2/HES1	15
GO:0003779	actin binding	19/313	440/18367	0.000210661658810857	0.00886283693139963	ALDOA/FLNB/EPS8L1/PDLIM2/COTL1/PFN1/CFL1/EZR/MYH9/ITGB1/TMSB4X/SCIN/TPM4/DST/TPM1/EPB41L3/IQGAP2/PHACTR2/FERMT1	19
GO:0003735	structural constituent of ribosome	11/313	182/18367	0.000298459667988263	0.0117195162963391	RPS29/RPL37A/RPS27/RPL23/RPS17/RPL31/RPS21/RPL38/RPS28/RPL4/RPL29	11
GO:0008509	anion transmembrane transporter activity	15/313	314/18367	0.000340211370305515	0.0125240310693718	SLC6A8/FXYD3/CLIC3/SLC7A5/CLIC4/SLC16A1/SLC26A2/SERINC5/CLIC1/SLC13A4/SLC22A11/SLC13A3/MPC2/GJA1/SLC2A1	15
GO:0044325	transmembrane transporter binding	9/313	133/18367	0.000463600532705852	0.0155381814128464	CAV1/TCAF1/SRI/PHPT1/HERPUD1/S100A10/PDE4B/CALM1/ID2	9
GO:0004602	glutathione peroxidase activity	4/313	22/18367	0.000474851044874762	0.0155381814128464	GPX3/GPX1/GPX4/PRDX6	4
GO:0070412	R-SMAD binding	4/313	23/18367	0.000567156575101197	0.0175818538281371	DDX5/FOS/JUN/PARP1	4
GO:0005539	glycosaminoglycan binding	12/313	230/18367	0.000610175475294854	0.017768068741638	FN1/FBN1/NRP2/CCDC80/RPL29/LAMC2/VEGFB/SOD3/PGF/EXTL2/TGFBR3/ADAMTS1	12
GO:1901681	sulfur compound binding	13/313	265/18367	0.000653440517284916	0.017768068741638	FN1/FBN1/NRP2/CCDC80/RPL29/LAMC2/VEGFB/SOD3/DBI/PGF/PRMT1/TGFBR3/ADAMTS1	13
GO:0016209	antioxidant activity	7/313	86/18367	0.000663663009025529	0.017768068741638	GPX3/GSTO1/GPX1/PRDX1/GPX4/SOD3/PRDX6	7
GO:0004866	endopeptidase inhibitor activity	10/313	180/18367	0.00106741802439982	0.0273351833204998	GAPDH/SERPINB9/TFPI2/TIMP2/ITIH5/TIMP3/SERPINB1/SERPINE1/PTTG1/BIRC5	10
GO:0004857	enzyme inhibitor activity	6/313	70/18367	0.0012256826243126	0.0290955450209911	ANXA4/RPL23/DYNLL1/ANXA1/OAZ1/TMBIM6	6
GO:0072542	protein phosphatase activator activity	3/313	13/18367	0.00123495522160404	0.0290955450209911	IGFBP3/CALM1/PPP1R15A	3
GO:0008514	organic anion transmembrane transporter activity	10/313	185/18367	0.00131263848138561	0.0297363102129279	SLC6A8/SLC7A5/SLC16A1/SLC26A2/SERINC5/SLC22A11/SLC13A3/MPC2/GJA1/SLC2A1	10
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4/313	29/18367	0.00140376334550279	0.0299287655945637	DHCR24/BLVRA/AKR1B1/TECR	4
GO:0030414	peptidase inhibitor activity	10/313	187/18367	0.00142275965475006	0.0299287655945637	GAPDH/SERPINB9/TFPI2/TIMP2/ITIH5/TIMP3/SERPINB1/SERPINE1/PTTG1/BIRC5	10
GO:0044548	S100 protein binding	3/313	14/18367	0.00155202550171286	0.0315221731209957	S100A6/EZR/AHNAK	3
GO:0004601	peroxidase activity	5/313	51/18367	0.00172148432637676	0.0337984756078637	GPX3/GPX1/PRDX1/GPX4/PRDX6	5
GO:0061135	endopeptidase regulator activity	10/313	194/18367	0.00186885887533542	0.0352607169051843	GAPDH/SERPINB9/TFPI2/TIMP2/ITIH5/TIMP3/SERPINB1/SERPINE1/PTTG1/BIRC5	10
GO:0050998	nitric-oxide synthase binding	3/313	15/18367	0.00191569259926298	0.0352607169051843	CAV1/CALM1/ACTB	3
GO:0002020	protease binding	8/313	135/18367	0.00222185352636718	0.0396567190009173	SERPINB9/FN1/TIMP2/TIMP3/SRI/SERPINE1/ITGB1/ADAMTSL4	8
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/313	55/18367	0.00241231523934953	0.0417898139993199	GPX3/GPX1/PRDX1/GPX4/PRDX6	5
GO:0035198	miRNA binding	4/313	34/18367	0.00256396591932324	0.0431478836137539	NEAT1/SOX4/YBX1/KCNQ1OT1	4
GO:0098641	cadherin binding involved in cell-cell adhesion	3/313	18/18367	0.00330813769187529	0.0541248083476263	KRT18/ANXA1/PKP3	3
GO:0019888	protein phosphatase regulator activity	6/313	89/18367	0.00415337150058709	0.0648342216227913	IGFBP3/PPP1R14B/PPP1R10/CALM1/PPP1R15A/PHACTR2	6
GO:0051015	actin filament binding	10/313	217/18367	0.00418285300792202	0.0648342216227913	FLNB/COTL1/CFL1/EZR/MYH9/SCIN/TPM4/TPM1/IQGAP2/FERMT1	10
GO:0019211	phosphatase activator activity	3/313	20/18367	0.00450686466905755	0.068065212566023	IGFBP3/CALM1/PPP1R15A	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/313	124/18367	0.00538515397320827	0.0792963922554917	LDHA/RDH13/DHRS2/HSD17B1/IDH1/LDHB/AKR1B1	7
GO:0097110	scaffold protein binding	5/313	67/18367	0.00567720365038853	0.0815578768311913	KRT8/KRT18/DYNLL1/DSP/CAV2	5
GO:0072349	modified amino acid transmembrane transporter activity	3/313	22/18367	0.00593725411585525	0.0819815069493961	SLC6A8/SLC13A3/GJA1	3
GO:0016504	peptidase activator activity	4/313	43/18367	0.00605338014079831	0.0819815069493961	CAV1/FN1/FBLN1/CTSC	4
GO:0042826	histone deacetylase binding	7/313	127/18367	0.00612425518807033	0.0819815069493961	CEBPB/HSPA1A/PARP1/CDC20/BHLHE41/TOP2A/HES1	7
GO:0046943	carboxylic acid transmembrane transporter activity	8/313	163/18367	0.00693751861702371	0.0907943695232794	SLC7A5/SLC27A2/SLC16A1/SLC26A2/SERINC5/SLC13A3/SLC43A2/MPC2	8
GO:0005342	organic acid transmembrane transporter activity	8/313	164/18367	0.00718863084046926	0.0907943695232794	SLC7A5/SLC27A2/SLC16A1/SLC26A2/SERINC5/SLC13A3/SLC43A2/MPC2	8
GO:0048029	monosaccharide binding	5/313	71/18367	0.00724505155788477	0.0907943695232794	ALDOA/PYGL/P4HA1/UGP2/BSG	5
GO:0043495	protein-membrane adaptor activity	3/313	24/18367	0.00761009001906551	0.0924668662519804	PDCD6/MYH9/EPB41L3	3
GO:0061980	regulatory RNA binding	4/313	46/18367	0.00769248972215117	0.0924668662519804	NEAT1/SOX4/YBX1/KCNQ1OT1	4
GO:0005200	structural constituent of cytoskeleton	6/313	103/18367	0.00839500596259904	0.0988931702394167	KRT19/ACTG1/DSP/TPM1/ACTB/EPB41L3	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	7/313	136/18367	0.00879741578599101	0.101601527410759	LDHA/RDH13/DHRS2/HSD17B1/IDH1/LDHB/AKR1B1	7
GO:0019208	phosphatase regulator activity	6/313	107/18367	0.0100329027578251	0.111497730648282	IGFBP3/PPP1R14B/PPP1R10/CALM1/PPP1R15A/PHACTR2	6
GO:0051087	chaperone binding	6/313	107/18367	0.0100329027578251	0.111497730648282	FN1/CTSC/BIRC5/DNAJB4/CLU/HES1	6
GO:0043425	bHLH transcription factor binding	3/313	27/18367	0.0105928497613421	0.115540527952417	ISL1/FHL2/BHLHE41	3
GO:0046332	SMAD binding	5/313	79/18367	0.0112411985934855	0.120383017664781	DDX5/FOS/JUN/PARP1/TGFBR3	5
GO:1901682	sulfur compound transmembrane transporter activity	4/313	52/18367	0.01178933705352	0.120862701087904	SLC26A2/SLC13A4/SLC13A3/GJA1	4
GO:0016922	nuclear receptor binding	7/313	144/18367	0.0118175171008321	0.120862701087904	DDX5/FUS/ISL1/CEBPB/PARP1/TACC2/HMGN3	7
GO:0008239	dipeptidyl-peptidase activity	2/313	10/18367	0.0119015902599295	0.120862701087904	DPP7/CTSC	2
GO:0005520	insulin-like growth factor binding	3/313	29/18367	0.0129067875147036	0.128849116036617	HTRA1/IGFBP3/INSR	3
GO:0005536	glucose binding	2/313	11/18367	0.014384003077409	0.13034119711683	PYGL/UGP2	2
GO:0008199	ferric iron binding	2/313	11/18367	0.014384003077409	0.13034119711683	FTL/FTH1	2
GO:0019855	calcium channel inhibitor activity	2/313	11/18367	0.014384003077409	0.13034119711683	PHPT1/CALM1	2
GO:0035673	oligopeptide transmembrane transporter activity	2/313	11/18367	0.014384003077409	0.13034119711683	SLC13A3/GJA1	2
GO:0097493	structural molecule activity conferring elasticity	2/313	11/18367	0.014384003077409	0.13034119711683	FBN1/AHNAK	2
GO:0099186	structural constituent of postsynapse	2/313	11/18367	0.014384003077409	0.13034119711683	ACTG1/ACTB	2
GO:0051287	NAD binding	4/313	56/18367	0.0151737136057761	0.135413898693971	GAPDH/LDHA/IDH1/PARP1	4
GO:0015103	inorganic anion transmembrane transporter activity	7/313	152/18367	0.0155242270536908	0.13647417514364	FXYD3/CLIC3/CLIC4/SLC26A2/CLIC1/SLC13A4/SLC22A11	7
GO:0003727	single-stranded RNA binding	5/313	87/18367	0.0165261800795695	0.143145883336271	ANXA1/EIF4H/HNRNPDL/EIF4B/SSB	5
GO:0008200	ion channel inhibitor activity	3/313	33/18367	0.01833614439781	0.153843471947178	CAV1/PHPT1/CALM1	3
GO:0016853	isomerase activity	7/313	158/18367	0.018799278079045	0.153843471947178	CYP2J2/TPI1/MIF/PGAM1/FKBP8/ISYNA1/TOP2A	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	4/313	60/18367	0.0191142832066754	0.153843471947178	DHCR24/BLVRA/AKR1B1/TECR	4
GO:0016248	channel inhibitor activity	3/313	34/18367	0.0198624842505668	0.153843471947178	CAV1/PHPT1/CALM1	3
GO:0004859	phospholipase inhibitor activity	2/313	13/18367	0.0199471993409524	0.153843471947178	ANXA4/ANXA1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/313	13/18367	0.0199471993409524	0.153843471947178	SLC26A2/SLC13A4	2
GO:0031994	insulin-like growth factor I binding	2/313	13/18367	0.0199471993409524	0.153843471947178	IGFBP3/INSR	2
GO:0052650	NADP-retinol dehydrogenase activity	2/313	13/18367	0.0199471993409524	0.153843471947178	RDH13/AKR1B1	2
GO:0044389	ubiquitin-like protein ligase binding	11/313	316/18367	0.020111964923485	0.153843471947178	NEK6/ACTG1/TPI1/RPL23/JUN/CEBPB/HSPA1A/TMBIM6/PRDX6/CLU/CCNB1	11
GO:0005172	vascular endothelial growth factor receptor binding	2/313	14/18367	0.0230130616474923	0.173778119363756	VEGFB/PGF	2
GO:0042056	chemoattractant activity	3/313	37/18367	0.0248495052648386	0.185270362037847	MIF/VEGFB/PGF	3
GO:0004867	serine-type endopeptidase inhibitor activity	5/313	98/18367	0.0261637226913626	0.189103133455383	SERPINB9/TFPI2/ITIH5/SERPINB1/SERPINE1	5
GO:1904680	peptide transmembrane transporter activity	2/313	15/18367	0.0262588107318352	0.189103133455383	SLC13A3/GJA1	2
GO:0008395	steroid hydroxylase activity	3/313	38/18367	0.0266478099775837	0.189103133455383	CYP2J2/CYP11A1/CYP19A1	3
GO:0015175	neutral amino acid transmembrane transporter activity	3/313	38/18367	0.0266478099775837	0.189103133455383	SLC7A5/SERINC5/SLC43A2	3
GO:0015631	tubulin binding	12/313	375/18367	0.0278048917015414	0.194965252526284	GAPDH/ALDOA/STMN3/CAPN6/CCSAP/EZR/PDE4B/DST/BIRC5/GJA1/STMN1/RGS2	12
GO:0005201	extracellular matrix structural constituent	7/313	172/18367	0.0282635710997404	0.195849922091142	TFPI2/FN1/FBN1/COL14A1/LAMC2/FBLN1/MFAP5	7
GO:0005159	insulin-like growth factor receptor binding	2/313	16/18367	0.0296774664971059	0.200919859388453	IGF2/INSR	2
GO:0008191	metalloendopeptidase inhibitor activity	2/313	16/18367	0.0296774664971059	0.200919859388453	TIMP2/TIMP3	2
GO:0031492	nucleosomal DNA binding	3/313	40/18367	0.030447622959784	0.201501684531604	MBD3/ACTB/HMGN3	3
GO:0044183	protein folding chaperone	3/313	40/18367	0.030447622959784	0.201501684531604	FKBP8/HSPA1A/HSPB1	3
GO:0019955	cytokine binding	6/313	139/18367	0.0319456974886406	0.201973766403494	NRP2/TNFRSF1A/CSF3R/ITGB1/CSF2RA/TGFBR3	6
GO:0099106	ion channel regulator activity	6/313	139/18367	0.0319456974886406	0.201973766403494	CAV1/FXYD3/SRI/PHPT1/CALM1/PRSS8	6
GO:0030331	estrogen receptor binding	3/313	41/18367	0.0324486740410134	0.201973766403494	FUS/ISL1/PARP1	3
GO:0031491	nucleosome binding	4/313	71/18367	0.0329853060380318	0.201973766403494	MBD3/SMARCA1/ACTB/HMGN3	4
GO:0005324	long-chain fatty acid transporter activity	2/313	17/18367	0.0332622331768064	0.201973766403494	SLC27A2/SLC2A1	2
GO:0008381	mechanosensitive ion channel activity	2/313	17/18367	0.0332622331768064	0.201973766403494	TMEM150C/TMC5	2
GO:0015116	sulfate transmembrane transporter activity	2/313	17/18367	0.0332622331768064	0.201973766403494	SLC26A2/SLC13A4	2
GO:0043024	ribosomal small subunit binding	2/313	17/18367	0.0332622331768064	0.201973766403494	EIF4H/EIF4B	2
GO:0019838	growth factor binding	6/313	141/18367	0.033909740875975	0.203303703209075	HTRA1/IGFBP3/NRP2/INSR/FLT1/TGFBR3	6
GO:0001046	core promoter sequence-specific DNA binding	3/313	42/18367	0.0345167577604542	0.203303703209075	FOS/CEBPB/NR3C1	3
GO:0008307	structural constituent of muscle	3/313	42/18367	0.0345167577604542	0.203303703209075	KRT19/TPM4/TPM1	3
GO:0000287	magnesium ion binding	8/313	221/18367	0.0361030847963188	0.207588815440162	PKM/NEK6/ENO1/PDCD6/IDH1/PGP/S100P/TOP2A	8
GO:0005246	calcium channel regulator activity	3/313	43/18367	0.0366515110819285	0.207588815440162	SRI/PHPT1/CALM1	3
GO:0008301	DNA binding, bending	2/313	18/18367	0.0370064951124228	0.207588815440162	HMGB3/TOP2A	2
GO:0055102	lipase inhibitor activity	2/313	18/18367	0.0370064951124228	0.207588815440162	ANXA4/ANXA1	2
GO:0098918	structural constituent of synapse	2/313	18/18367	0.0370064951124228	0.207588815440162	ACTG1/ACTB	2
GO:0005254	chloride channel activity	4/313	74/18367	0.0375665046825346	0.208742181679367	FXYD3/CLIC3/CLIC4/CLIC1	4
GO:0016247	channel regulator activity	6/313	145/18367	0.0380682682653614	0.209553364563531	CAV1/FXYD3/SRI/PHPT1/CALM1/PRSS8	6
GO:0047485	protein N-terminus binding	5/313	110/18367	0.040108267768715	0.218738608479381	RPS21/HSPA1A/PARP1/CALM1/EIF5A	5
GO:0048156	tau protein binding	3/313	45/18367	0.0411193313826659	0.222195286095323	ACTB/CLU/LGMN	3
GO:0043021	ribonucleoprotein complex binding	6/313	149/18367	0.0425390174021499	0.227777102271512	DDX5/NEAT1/EIF4H/YBX3/EIF4B/EIF5A	6
GO:0004864	protein phosphatase inhibitor activity	3/313	46/18367	0.0434514366147948	0.230566632127154	PPP1R14B/PPP1R10/PHACTR2	3
GO:0005506	iron ion binding	6/313	151/18367	0.0448930769364158	0.232230909401305	CYP2J2/CYP11A1/P4HA1/FTL/CYP19A1/FTH1	6
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/313	20/18367	0.0449479179486397	0.232230909401305	FOS/CEBPB	2
GO:0016500	protein-hormone receptor activity	2/313	20/18367	0.0449479179486397	0.232230909401305	INSR/LGR5	2
GO:0019212	phosphatase inhibitor activity	3/313	49/18367	0.0508338811788093	0.25811341391654	PPP1R14B/PPP1R10/PHACTR2	3
GO:0043539	protein serine/threonine kinase activator activity	3/313	49/18367	0.0508338811788093	0.25811341391654	IGF2/CALM1/CCNB1	3
GO:0008106	alcohol dehydrogenase (NADP+) activity	2/313	22/18367	0.0534522570347297	0.264566213390385	RDH13/AKR1B1	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/313	22/18367	0.0534522570347297	0.264566213390385	SERPINB9/BIRC5	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/313	22/18367	0.0534522570347297	0.264566213390385	RPL23/CDC20	2
GO:0046982	protein heterodimerization activity	10/313	328/18367	0.0552900266546724	0.269396749195815	CAV1/SRI/CAV2/CEBPB/ITGB1/TPM4/TPM1/BHLHE41/JAM3/TOP2A	10
GO:0030165	PDZ domain binding	4/313	84/18367	0.0553429654544884	0.269396749195815	PLEKHA2/ATP2B1/GJA1/TGFBR3	4
GO:0005253	anion channel activity	4/313	87/18367	0.0614220847218682	0.294758322954539	FXYD3/CLIC3/CLIC4/CLIC1	4
GO:0050661	NADP binding	3/313	53/18367	0.0615539452010328	0.294758322954539	GAPDH/HSD17B1/IDH1	3
GO:0005112	Notch binding	2/313	25/18367	0.0671624338595537	0.311629894155012	GALNT11/AAK1	2
GO:0008327	methyl-CpG binding	2/313	25/18367	0.0671624338595537	0.311629894155012	MBD3/PRMT1	2
GO:0035035	histone acetyltransferase binding	2/313	25/18367	0.0671624338595537	0.311629894155012	CEBPB/EGR1	2
GO:0005080	protein kinase C binding	3/313	55/18367	0.0672766459458854	0.311629894155012	DSP/HSPB1/TOP2A	3
GO:0030674	protein-macromolecule adaptor activity	9/313	296/18367	0.0677226255549092	0.311629894155012	CAV1/COL14A1/PDCD6/CAV2/ICE1/MYH9/HERPUD1/EPB41L3/AP2A2	9
GO:0031625	ubiquitin protein ligase binding	9/313	297/18367	0.0688502999762768	0.314362997566101	NEK6/ACTG1/TPI1/RPL23/JUN/HSPA1A/TMBIM6/PRDX6/CLU	9
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/313	56/18367	0.0702258685311746	0.318177204345091	SERPINB9/PTTG1/BIRC5	3
GO:0017124	SH3 domain binding	5/313	130/18367	0.0717940964931612	0.321115585008187	ADAM12/GPX1/PTTG1/GJA1/ERRFI1	5
GO:0008198	ferrous iron binding	2/313	26/18367	0.0719647830578619	0.321115585008187	FTL/FTH1	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/313	58/18367	0.076295794766933	0.337881376824989	SLC27A2/SLC16A1/MPC2	3
GO:0016866	intramolecular transferase activity	2/313	27/18367	0.0768745377215834	0.33790375162696	CYP2J2/PGAM1	2
GO:0003785	actin monomer binding	2/313	28/18367	0.0818866698926899	0.352052909246674	PFN1/TMSB4X	2
GO:0043236	laminin binding	2/313	28/18367	0.0818866698926899	0.352052909246674	PLEKHA2/ITGB1	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/313	28/18367	0.0818866698926899	0.352052909246674	PDCD6/HERPUD1	2
GO:0015179	L-amino acid transmembrane transporter activity	3/313	61/18367	0.0858159893933843	0.366005823477438	SLC7A5/SERINC5/SLC43A2	3
GO:0004033	aldo-keto reductase (NADP) activity	2/313	29/18367	0.0869962908095777	0.366005823477438	RDH13/AKR1B1	2
GO:0051787	misfolded protein binding	2/313	29/18367	0.0869962908095777	0.366005823477438	HSPA1A/CLU	2
GO:1990841	promoter-specific chromatin binding	3/313	62/18367	0.0890964397871517	0.371237377378641	DDX5/ISL1/EGR1	3
GO:0020037	heme binding	5/313	139/18367	0.0895003524410306	0.371237377378641	CYP2J2/CYP11A1/STC2/CYP19A1/BACH1	5
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/313	30/18367	0.0921986476482138	0.377118079616652	SLC26A2/SLC13A3	2
GO:0046966	thyroid hormone receptor binding	2/313	30/18367	0.0921986476482138	0.377118079616652	FUS/HMGN3	2
GO:0030246	carbohydrate binding	8/313	271/18367	0.0932881983120821	0.378943095212527	ALDOA/SIGLEC6/PYGL/P4HA1/GALNT11/UGP2/BSG/AGL	8
GO:0008238	exopeptidase activity	4/313	103/18367	0.099403021679746	0.401016299790208	DPP7/CNDP2/CPVL/CTSC	4
GO:0008022	protein C-terminus binding	6/313	189/18367	0.104959210450398	0.420550850035949	FN1/FBLN1/EZR/DST/CDC20/TOP2A	6
GO:0046906	tetrapyrrole binding	5/313	149/18367	0.111571091243326	0.441149215714469	CYP2J2/CYP11A1/STC2/CYP19A1/BACH1	5
GO:0005518	collagen binding	3/313	69/18367	0.113458827696339	0.441149215714469	FN1/COL14A1/ITGB1	3
GO:0008376	acetylgalactosaminyltransferase activity	2/313	34/18367	0.113844958894057	0.441149215714469	GALNT11/EXTL2	2
GO:0043548	phosphatidylinositol 3-kinase binding	2/313	34/18367	0.113844958894057	0.441149215714469	INSR/CALM1	2
GO:0045505	dynein intermediate chain binding	2/313	34/18367	0.113844958894057	0.441149215714469	DYNLL1/DYNLRB1	2
GO:0015291	secondary active transmembrane transporter activity	7/313	240/18367	0.117084543270408	0.450737228668433	SLC6A8/SLC7A5/SLC16A1/SLC26A2/SLC13A4/SLC22A11/SLC13A3	7
GO:0042887	amide transmembrane transporter activity	2/313	35/18367	0.119444241386879	0.456835442706958	SLC13A3/GJA1	2
GO:0042605	peptide antigen binding	2/313	36/18367	0.125110423702454	0.474348804457019	SLC7A5/DHCR24	2
GO:0051020	GTPase binding	8/313	291/18367	0.125633978769601	0.474348804457019	CAV1/ENO1/PFN1/YBX3/BIRC5/YBX1/ERRFI1/IQGAP2	8
GO:0015370	solute:sodium symporter activity	3/313	73/18367	0.12839105711722	0.481653347597428	SLC6A8/SLC13A4/SLC13A3	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/313	37/18367	0.130839619041746	0.481653347597428	GAPDH/AKR1B1	2
GO:0043531	ADP binding	2/313	37/18367	0.130839619041746	0.481653347597428	PGK1/MYH9	2
GO:0071949	FAD binding	2/313	37/18367	0.130839619041746	0.481653347597428	DHCR24/CYB5R1	2
GO:0019003	GDP binding	3/313	75/18367	0.136106132115428	0.488814506270548	RAB17/RHOA/RHOB	3
GO:0001618	virus receptor activity	3/313	76/18367	0.140022268511275	0.488814506270548	BSG/ITGB1/HSPA1A	3
GO:0140272	exogenous protein binding	3/313	77/18367	0.143976081040967	0.488814506270548	BSG/ITGB1/HSPA1A	3
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/313	40/18367	0.148368083299621	0.488814506270548	CYP2J2/CYP19A1	2
GO:0017080	sodium channel regulator activity	2/313	40/18367	0.148368083299621	0.488814506270548	FXYD3/PRSS8	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/313	40/18367	0.148368083299621	0.488814506270548	SERPINB9/BIRC5	2
GO:0016835	carbon-oxygen lyase activity	3/313	79/18367	0.151992567900701	0.488814506270548	TPI1/ENO1/HACD3	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/313	41/18367	0.154312668389806	0.488814506270548	SLC27A2/UBA5	2
GO:0022804	active transmembrane transporter activity	10/313	406/18367	0.15725652514294	0.488814506270548	SLC6A8/SLC7A5/ATP2B1/SLC16A1/COX4I1/SLC26A2/SLC13A4/SLC22A11/SLC13A3/NDUFB1	10
GO:0005031	tumor necrosis factor-activated receptor activity	1/313	10/18367	0.157958167472983	0.488814506270548	TNFRSF1A	1
GO:0005522	profilin binding	1/313	10/18367	0.157958167472983	0.488814506270548	ACTG1	1
GO:0008172	S-methyltransferase activity	1/313	10/18367	0.157958167472983	0.488814506270548	DNMT3A	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/313	10/18367	0.157958167472983	0.488814506270548	UBA5	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/313	10/18367	0.157958167472983	0.488814506270548	SLC7A5	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/313	10/18367	0.157958167472983	0.488814506270548	CYB5R1	1
GO:0016783	sulfurtransferase activity	1/313	10/18367	0.157958167472983	0.488814506270548	MOCS2	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/313	10/18367	0.157958167472983	0.488814506270548	PGAM1	1
GO:0019531	oxalate transmembrane transporter activity	1/313	10/18367	0.157958167472983	0.488814506270548	SLC26A2	1
GO:0030957	Tat protein binding	1/313	10/18367	0.157958167472983	0.488814506270548	ACTB	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/313	10/18367	0.157958167472983	0.488814506270548	SLC27A2	1
GO:0035612	AP-2 adaptor complex binding	1/313	10/18367	0.157958167472983	0.488814506270548	AAK1	1
GO:0045294	alpha-catenin binding	1/313	10/18367	0.157958167472983	0.488814506270548	PKP3	1
GO:0070008	serine-type exopeptidase activity	1/313	10/18367	0.157958167472983	0.488814506270548	CPVL	1
GO:0097027	ubiquitin-protein transferase activator activity	1/313	10/18367	0.157958167472983	0.488814506270548	CDC20	1
GO:0015036	disulfide oxidoreductase activity	2/313	42/18367	0.160302463921273	0.488814506270548	GSTO1/PGK1	2
GO:0019894	kinesin binding	2/313	42/18367	0.160302463921273	0.488814506270548	NEK6/ACTB	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/313	82/18367	0.164273871731241	0.488814506270548	PFN1/SCIN/EXOC1	3
GO:0004180	carboxypeptidase activity	2/313	43/18367	0.166334217718314	0.488814506270548	CNDP2/CPVL	2
GO:0009055	electron transfer activity	4/313	126/18367	0.168367016267801	0.488814506270548	CYP19A1/COX4I1/AKR1B1/NDUFB1	4
GO:0000774	adenyl-nucleotide exchange factor activity	1/313	11/18367	0.172315583912541	0.488814506270548	PFN1	1
GO:0016273	arginine N-methyltransferase activity	1/313	11/18367	0.172315583912541	0.488814506270548	PRMT1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/313	11/18367	0.172315583912541	0.488814506270548	PRMT1	1
GO:0016832	aldehyde-lyase activity	1/313	11/18367	0.172315583912541	0.488814506270548	ALDOA	1
GO:0019107	myristoyltransferase activity	1/313	11/18367	0.172315583912541	0.488814506270548	NMT1	1
GO:0022889	serine transmembrane transporter activity	1/313	11/18367	0.172315583912541	0.488814506270548	SERINC5	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/313	11/18367	0.172315583912541	0.488814506270548	HSD17B1	1
GO:0032052	bile acid binding	1/313	11/18367	0.172315583912541	0.488814506270548	PYGL	1
GO:0042608	T cell receptor binding	1/313	11/18367	0.172315583912541	0.488814506270548	EPS8L1	1
GO:0043560	insulin receptor substrate binding	1/313	11/18367	0.172315583912541	0.488814506270548	INSR	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/313	11/18367	0.172315583912541	0.488814506270548	PGK1	1
GO:0047676	arachidonate-CoA ligase activity	1/313	11/18367	0.172315583912541	0.488814506270548	SLC27A2	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/313	11/18367	0.172315583912541	0.488814506270548	DSP	1
GO:0022853	active ion transmembrane transporter activity	7/313	267/18367	0.172377551970481	0.488814506270548	SLC6A8/ATP2B1/COX4I1/SLC26A2/SLC13A4/SLC22A11/SLC13A3	7
GO:0008375	acetylglucosaminyltransferase activity	2/313	44/18367	0.172404774663256	0.488814506270548	EXTL2/B3GNT2	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/313	44/18367	0.172404774663256	0.488814506270548	GAPDH/AKR1B1	2
GO:0001540	amyloid-beta binding	3/313	84/18367	0.172620402893504	0.488814506270548	ITM2B/INSR/CLU	3
GO:0008135	translation factor activity, RNA binding	3/313	84/18367	0.172620402893504	0.488814506270548	EIF4H/EIF4B/EIF5A	3
GO:0015171	amino acid transmembrane transporter activity	3/313	84/18367	0.172620402893504	0.488814506270548	SLC7A5/SERINC5/SLC43A2	3
GO:1901981	phosphatidylinositol phosphate binding	5/313	173/18367	0.173761879895406	0.489692570614325	PHLDA2/PFN1/SCIN/IQGAP2/EXOC1	5
GO:0060090	molecular adaptor activity	9/313	369/18367	0.180255151153996	0.501400275583192	CAV1/COL14A1/PDCD6/CAV2/ICE1/MYH9/HERPUD1/EPB41L3/AP2A2	9
GO:0003995	acyl-CoA dehydrogenase activity	1/313	12/18367	0.186428964945194	0.501400275583192	TECR	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/313	12/18367	0.186428964945194	0.501400275583192	AKR1B1	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/313	12/18367	0.186428964945194	0.501400275583192	TGFBR3	1
GO:0005095	GTPase inhibitor activity	1/313	12/18367	0.186428964945194	0.501400275583192	IQGAP2	1
GO:0017154	semaphorin receptor activity	1/313	12/18367	0.186428964945194	0.501400275583192	NRP2	1
GO:0030955	potassium ion binding	1/313	12/18367	0.186428964945194	0.501400275583192	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/313	12/18367	0.186428964945194	0.501400275583192	P4HA1	1
GO:0033130	acetylcholine receptor binding	1/313	12/18367	0.186428964945194	0.501400275583192	LY6E	1
GO:0035256	G protein-coupled glutamate receptor binding	1/313	12/18367	0.186428964945194	0.501400275583192	CALM1	1
GO:0035254	glutamate receptor binding	2/313	47/18367	0.190819120177251	0.506343949990532	FUS/CALM1	2
GO:0015026	coreceptor activity	2/313	48/18367	0.197015198668026	0.506343949990532	ITGB1/TGFBR3	2
GO:0070888	E-box binding	2/313	48/18367	0.197015198668026	0.506343949990532	BHLHE41/HES1	2
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/313	13/18367	0.200302445412214	0.506343949990532	PPP1R14B	1
GO:0005035	death receptor activity	1/313	13/18367	0.200302445412214	0.506343949990532	TNFRSF1A	1
GO:0008179	adenylate cyclase binding	1/313	13/18367	0.200302445412214	0.506343949990532	CALM1	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/313	13/18367	0.200302445412214	0.506343949990532	PGK1	1
GO:0031404	chloride ion binding	1/313	13/18367	0.200302445412214	0.506343949990532	CTSC	1
GO:0031432	titin binding	1/313	13/18367	0.200302445412214	0.506343949990532	CALM1	1
GO:0034236	protein kinase A catalytic subunit binding	1/313	13/18367	0.200302445412214	0.506343949990532	EZR	1
GO:0060590	ATPase regulator activity	1/313	13/18367	0.200302445412214	0.506343949990532	PFN1	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/313	13/18367	0.200302445412214	0.506343949990532	CCNB1	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/313	13/18367	0.200302445412214	0.506343949990532	HSD17B1	1
GO:0140299	small molecule sensor activity	1/313	13/18367	0.200302445412214	0.506343949990532	EFHD1	1
GO:0043130	ubiquitin binding	3/313	92/18367	0.207102332817259	0.509756921964226	HSPB1/N4BP2/TOP2A	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	2/313	50/18367	0.209477944693823	0.509756921964226	CCNL1/CCNB1	2
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/313	14/18367	0.213940090317193	0.509756921964226	B3GNT2	1
GO:0015373	anion:sodium symporter activity	1/313	14/18367	0.213940090317193	0.509756921964226	SLC13A4	1
GO:0015562	efflux transmembrane transporter activity	1/313	14/18367	0.213940090317193	0.509756921964226	GJA1	1
GO:0015926	glucosidase activity	1/313	14/18367	0.213940090317193	0.509756921964226	AGL	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/313	14/18367	0.213940090317193	0.509756921964226	MIF	1
GO:0035259	glucocorticoid receptor binding	1/313	14/18367	0.213940090317193	0.509756921964226	CEBPB	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/313	14/18367	0.213940090317193	0.509756921964226	HSD17B1	1
GO:0071837	HMG box domain binding	1/313	14/18367	0.213940090317193	0.509756921964226	JUN	1
GO:0003714	transcription corepressor activity	5/313	187/18367	0.21501950551938	0.509756921964226	TLE4/HSPA1A/FHL2/BTG2/DNMT3A	5
GO:0003743	translation initiation factor activity	2/313	51/18367	0.21573945337015	0.509756921964226	EIF4H/EIF4B	2
GO:0016860	intramolecular oxidoreductase activity	2/313	51/18367	0.21573945337015	0.509756921964226	TPI1/MIF	2
GO:0016830	carbon-carbon lyase activity	2/313	52/18367	0.222017747374933	0.509756921964226	ALDOA/NPL	2
GO:0008236	serine-type peptidase activity	5/313	191/18367	0.227341142256323	0.509756921964226	HTRA1/DPP7/CPVL/CTSC/PRSS8	5
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/313	15/18367	0.227345896001861	0.509756921964226	PDE4B	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/313	15/18367	0.227345896001861	0.509756921964226	SLC27A2	1
GO:0005452	inorganic anion exchanger activity	1/313	15/18367	0.227345896001861	0.509756921964226	SLC22A11	1
GO:0005545	1-phosphatidylinositol binding	1/313	15/18367	0.227345896001861	0.509756921964226	SCIN	1
GO:0010851	cyclase regulator activity	1/313	15/18367	0.227345896001861	0.509756921964226	CALM1	1
GO:0016805	dipeptidase activity	1/313	15/18367	0.227345896001861	0.509756921964226	CNDP2	1
GO:0030548	acetylcholine receptor regulator activity	1/313	15/18367	0.227345896001861	0.509756921964226	LY6E	1
GO:0048185	activin binding	1/313	15/18367	0.227345896001861	0.509756921964226	TGFBR3	1
GO:0051371	muscle alpha-actinin binding	1/313	15/18367	0.227345896001861	0.509756921964226	PDLIM2	1
GO:0071933	Arp2/3 complex binding	1/313	15/18367	0.227345896001861	0.509756921964226	IQGAP2	1
GO:0099602	neurotransmitter receptor regulator activity	1/313	15/18367	0.227345896001861	0.509756921964226	LY6E	1
GO:1990825	sequence-specific mRNA binding	1/313	15/18367	0.227345896001861	0.509756921964226	SSB	1
GO:0019199	transmembrane receptor protein kinase activity	4/313	143/18367	0.227515848214669	0.509756921964226	NRP2/INSR/FLT1/TGFBR3	4
GO:0015293	symporter activity	4/313	144/18367	0.231152619409395	0.509756921964226	SLC6A8/SLC16A1/SLC13A4/SLC13A3	4
GO:0005544	calcium-dependent phospholipid binding	2/313	54/18367	0.234615242323333	0.509756921964226	ANXA4/ANXA1	2
GO:0008374	O-acyltransferase activity	2/313	54/18367	0.234615242323333	0.509756921964226	CROT/PRDX6	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	10/313	450/18367	0.239844920637211	0.509756921964226	FOS/JUN/FOSB/BACH1/ISL1/SOX4/TFDP2/CEBPB/EGR1/NR3C1	10
GO:0017171	serine hydrolase activity	5/313	195/18367	0.239865271384419	0.509756921964226	HTRA1/DPP7/CPVL/CTSC/PRSS8	5
GO:0005523	tropomyosin binding	1/313	16/18367	0.240523791302178	0.509756921964226	S100A6	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/313	16/18367	0.240523791302178	0.509756921964226	SLC22A11	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/313	16/18367	0.240523791302178	0.509756921964226	SLC13A3	1
GO:0016208	AMP binding	1/313	16/18367	0.240523791302178	0.509756921964226	PYGL	1
GO:0017070	U6 snRNA binding	1/313	16/18367	0.240523791302178	0.509756921964226	EIF5A	1
GO:0035497	cAMP response element binding	1/313	16/18367	0.240523791302178	0.509756921964226	JUN	1
GO:1990404	protein ADP-ribosylase activity	1/313	16/18367	0.240523791302178	0.509756921964226	PARP1	1
GO:0005496	steroid binding	3/313	100/18367	0.242960500181425	0.509756921964226	CAV1/HSD17B1/NR3C1	3
GO:0016829	lyase activity	5/313	196/18367	0.243025696048945	0.509756921964226	ALDOA/TPI1/ENO1/HACD3/NPL	5
GO:0016758	hexosyltransferase activity	5/313	197/18367	0.246197277395754	0.509756921964226	PYGL/GALNT11/AGL/EXTL2/B3GNT2	5
GO:0050840	extracellular matrix binding	2/313	56/18367	0.247252278108184	0.509756921964226	PLEKHA2/ITGB1	2
GO:0030295	protein kinase activator activity	3/313	101/18367	0.24751548451533	0.509756921964226	IGF2/CALM1/CCNB1	3
GO:0004497	monooxygenase activity	3/313	102/18367	0.252083622463662	0.509756921964226	CYP2J2/CYP11A1/CYP19A1	3
GO:0001216	DNA-binding transcription activator activity	10/313	456/18367	0.252200561853979	0.509756921964226	FOS/JUN/FOSB/BACH1/ISL1/SOX4/TFDP2/CEBPB/EGR1/NR3C1	10
GO:0000400	four-way junction DNA binding	1/313	17/18367	0.253477638685014	0.509756921964226	HMGB3	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/313	17/18367	0.253477638685014	0.509756921964226	PTPRA	1
GO:0008392	arachidonic acid epoxygenase activity	1/313	17/18367	0.253477638685014	0.509756921964226	CYP2J2	1
GO:0015108	chloride transmembrane transporter activity	1/313	17/18367	0.253477638685014	0.509756921964226	SLC26A2	1
GO:0015278	calcium-release channel activity	1/313	17/18367	0.253477638685014	0.509756921964226	MCOLN3	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/313	17/18367	0.253477638685014	0.509756921964226	FTH1	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/313	17/18367	0.253477638685014	0.509756921964226	PTPRA	1
GO:0031420	alkali metal ion binding	1/313	17/18367	0.253477638685014	0.509756921964226	PKM	1
GO:0031489	myosin V binding	1/313	17/18367	0.253477638685014	0.509756921964226	FUS	1
GO:0046965	retinoid X receptor binding	1/313	17/18367	0.253477638685014	0.509756921964226	FUS	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/313	17/18367	0.253477638685014	0.509756921964226	B3GNT2	1
GO:0070064	proline-rich region binding	1/313	17/18367	0.253477638685014	0.509756921964226	PFN1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	2/313	57/18367	0.253580268481355	0.509756921964226	GSTO1/PGK1	2
GO:0031490	chromatin DNA binding	3/313	103/18367	0.256664040487179	0.514201087914791	MBD3/ACTB/HMGN3	3
GO:0005516	calmodulin binding	5/313	201/18367	0.25898916776905	0.517100406155833	DDX5/ATP2B1/MYH9/IQGAP2/RGS2	5
GO:0015294	solute:cation symporter activity	3/313	104/18367	0.261255875637107	0.519863887669784	SLC6A8/SLC13A4/SLC13A3	3
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/313	18/18367	0.266211235365754	0.520991221311952	HSD17B1	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/313	18/18367	0.266211235365754	0.520991221311952	AKR1B1	1
GO:0140597	protein carrier activity	1/313	18/18367	0.266211235365754	0.520991221311952	CLU	1
GO:1904047	S-adenosyl-L-methionine binding	1/313	18/18367	0.266211235365754	0.520991221311952	PRMT1	1
GO:0036002	pre-mRNA binding	2/313	59/18367	0.266245089329198	0.520991221311952	DDX5/TRA2B	2
GO:0019887	protein kinase regulator activity	5/313	204/18367	0.268685540062102	0.524025771842973	IGF2/HSPB1/CALM1/CCNL1/CCNB1	5
GO:0019209	kinase activator activity	3/313	107/18367	0.275091416292765	0.526375012113797	IGF2/CALM1/CCNB1	3
GO:1902936	phosphatidylinositol bisphosphate binding	3/313	107/18367	0.275091416292765	0.526375012113797	PFN1/SCIN/EXOC1	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7/313	310/18367	0.278307774768769	0.526375012113797	ENO1/JUN/BACH1/CEBPB/BHLHE41/NR3C1/HES1	7
GO:0003746	translation elongation factor activity	1/313	19/18367	0.278728314407147	0.526375012113797	EIF5A	1
GO:0004129	cytochrome-c oxidase activity	1/313	19/18367	0.278728314407147	0.526375012113797	COX4I1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/313	19/18367	0.278728314407147	0.526375012113797	GALNT11	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/313	19/18367	0.278728314407147	0.526375012113797	TGFBR3	1
GO:0035615	clathrin adaptor activity	1/313	19/18367	0.278728314407147	0.526375012113797	AP2A2	1
GO:0005507	copper ion binding	2/313	61/18367	0.278908995529424	0.526375012113797	F5/SOD3	2
GO:0043621	protein self-association	2/313	61/18367	0.278908995529424	0.526375012113797	CTSC/SLC2A1	2
GO:0090079	translation regulator activity, nucleic acid binding	3/313	108/18367	0.279720507286279	0.526375012113797	EIF4H/EIF4B/EIF5A	3
GO:0031267	small GTPase binding	6/313	259/18367	0.280812797735114	0.526747572821599	CAV1/PFN1/YBX3/BIRC5/ERRFI1/IQGAP2	6
GO:0001217	DNA-binding transcription repressor activity	7/313	313/18367	0.286285968177476	0.53382342811752	ENO1/JUN/BACH1/CEBPB/BHLHE41/NR3C1/HES1	7
GO:0016408	C-acyltransferase activity	1/313	20/18367	0.2910325457997	0.53382342811752	SPTSSA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/313	20/18367	0.2910325457997	0.53382342811752	CTSC	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/313	20/18367	0.2910325457997	0.53382342811752	COX4I1	1
GO:0031418	L-ascorbic acid binding	1/313	20/18367	0.2910325457997	0.53382342811752	P4HA1	1
GO:0031690	adrenergic receptor binding	1/313	20/18367	0.2910325457997	0.53382342811752	ARRDC3	1
GO:0140312	cargo adaptor activity	1/313	20/18367	0.2910325457997	0.53382342811752	AP2A2	1
GO:0004222	metalloendopeptidase activity	3/313	111/18367	0.293648201545121	0.53382342811752	ADAM12/ADAMTS6/ADAMTS1	3
GO:0008094	ATP-dependent activity, acting on DNA	3/313	111/18367	0.293648201545121	0.53382342811752	ANXA1/SMARCA1/TOP2A	3
GO:0032182	ubiquitin-like protein binding	3/313	111/18367	0.293648201545121	0.53382342811752	HSPB1/N4BP2/TOP2A	3
GO:0016836	hydro-lyase activity	2/313	64/18367	0.297871998801112	0.534557244316176	ENO1/HACD3	2
GO:0005123	death receptor binding	1/313	21/18367	0.303127537523944	0.534557244316176	TMBIM1	1
GO:0005243	gap junction channel activity	1/313	21/18367	0.303127537523944	0.534557244316176	GJA1	1
GO:0008391	arachidonic acid monooxygenase activity	1/313	21/18367	0.303127537523944	0.534557244316176	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/313	21/18367	0.303127537523944	0.534557244316176	ATP2B1	1
GO:0051010	microtubule plus-end binding	1/313	21/18367	0.303127537523944	0.534557244316176	DST	1
GO:0070577	lysine-acetylated histone binding	1/313	21/18367	0.303127537523944	0.534557244316176	BRD2	1
GO:0140033	acetylation-dependent protein binding	1/313	21/18367	0.303127537523944	0.534557244316176	BRD2	1
GO:0140358	P-type transmembrane transporter activity	1/313	21/18367	0.303127537523944	0.534557244316176	ATP2B1	1
GO:0140416	transcription regulator inhibitor activity	1/313	21/18367	0.303127537523944	0.534557244316176	ID2	1
GO:0016757	glycosyltransferase activity	6/313	270/18367	0.313306121879451	0.539374758006895	PYGL/GALNT11/AGL/PARP1/EXTL2/B3GNT2	6
GO:0000062	fatty-acyl-CoA binding	1/313	22/18367	0.315016836594859	0.539374758006895	DBI	1
GO:0005355	glucose transmembrane transporter activity	1/313	22/18367	0.315016836594859	0.539374758006895	SLC2A1	1
GO:0005537	mannose binding	1/313	22/18367	0.315016836594859	0.539374758006895	BSG	1
GO:0008093	cytoskeletal anchor activity	1/313	22/18367	0.315016836594859	0.539374758006895	EPB41L3	1
GO:0015106	bicarbonate transmembrane transporter activity	1/313	22/18367	0.315016836594859	0.539374758006895	SLC26A2	1
GO:0015149	hexose transmembrane transporter activity	1/313	22/18367	0.315016836594859	0.539374758006895	SLC2A1	1
GO:0015296	anion:cation symporter activity	1/313	22/18367	0.315016836594859	0.539374758006895	SLC13A4	1
GO:0015645	fatty acid ligase activity	1/313	22/18367	0.315016836594859	0.539374758006895	SLC27A2	1
GO:0033691	sialic acid binding	1/313	22/18367	0.315016836594859	0.539374758006895	SIGLEC6	1
GO:0008017	microtubule binding	6/313	271/18367	0.316292497813741	0.539989220905198	GAPDH/CAPN6/CCSAP/EZR/DST/BIRC5	6
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/313	23/18367	0.32670393008877	0.540529816916533	PARP1	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/313	23/18367	0.32670393008877	0.540529816916533	PDE4B	1
GO:0005158	insulin receptor binding	1/313	23/18367	0.32670393008877	0.540529816916533	IGF2	1
GO:0008143	poly(A) binding	1/313	23/18367	0.32670393008877	0.540529816916533	HNRNPDL	1
GO:0017134	fibroblast growth factor binding	1/313	23/18367	0.32670393008877	0.540529816916533	TGFBR3	1
GO:0030215	semaphorin receptor binding	1/313	23/18367	0.32670393008877	0.540529816916533	SEMA6D	1
GO:0030552	cAMP binding	1/313	23/18367	0.32670393008877	0.540529816916533	PDE4B	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/313	23/18367	0.32670393008877	0.540529816916533	ABHD8	1
GO:0050750	low-density lipoprotein particle receptor binding	1/313	23/18367	0.32670393008877	0.540529816916533	CLU	1
GO:0071617	lysophospholipid acyltransferase activity	1/313	23/18367	0.32670393008877	0.540529816916533	ABHD8	1
GO:1901567	fatty acid derivative binding	1/313	23/18367	0.32670393008877	0.540529816916533	DBI	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	5/313	222/18367	0.328242254475307	0.541553747579709	CROT/ABHD8/SPTSSA/NMT1/PRDX6	5
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	4/313	170/18367	0.329383225031686	0.541918211015819	CYP2J2/CYP11A1/P4HA1/CYP19A1	4
GO:0004674	protein serine/threonine kinase activity	8/313	386/18367	0.337440088482683	0.54619776448041	NEK6/AAK1/STK24/STK17A/MAP3K4/TGFBR3/PLK2/BRD2	8
GO:0001965	G-protein alpha-subunit binding	1/313	24/18367	0.338192246152999	0.54619776448041	RGS2	1
GO:0003707	steroid hormone receptor activity	1/313	24/18367	0.338192246152999	0.54619776448041	NR3C1	1
GO:0015145	monosaccharide transmembrane transporter activity	1/313	24/18367	0.338192246152999	0.54619776448041	SLC2A1	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/313	24/18367	0.338192246152999	0.54619776448041	GAPDH	1
GO:0050431	transforming growth factor beta binding	1/313	24/18367	0.338192246152999	0.54619776448041	TGFBR3	1
GO:0005179	hormone activity	3/313	122/18367	0.344943971119661	0.54619776448041	IGF2/FBN1/STC2	3
GO:0051082	unfolded protein binding	3/313	122/18367	0.344943971119661	0.54619776448041	HSPA1A/DNAJB4/CLU	3
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	2/313	72/18367	0.347949401244445	0.54619776448041	COX4I1/NDUFB1	2
GO:0030276	clathrin binding	2/313	72/18367	0.347949401244445	0.54619776448041	CLTB/AP2A2	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/313	25/18367	0.349485154998559	0.54619776448041	PDE4B	1
GO:0005160	transforming growth factor beta receptor binding	1/313	25/18367	0.349485154998559	0.54619776448041	TGFBR3	1
GO:0008266	poly(U) RNA binding	1/313	25/18367	0.349485154998559	0.54619776448041	SSB	1
GO:0030247	polysaccharide binding	1/313	25/18367	0.349485154998559	0.54619776448041	AGL	1
GO:0034237	protein kinase A regulatory subunit binding	1/313	25/18367	0.349485154998559	0.54619776448041	EZR	1
GO:0051019	mitogen-activated protein kinase binding	1/313	25/18367	0.349485154998559	0.54619776448041	PRMT1	1
GO:0070330	aromatase activity	1/313	25/18367	0.349485154998559	0.54619776448041	CYP19A1	1
GO:0120227	acyl-CoA binding	1/313	25/18367	0.349485154998559	0.54619776448041	DBI	1
GO:0003697	single-stranded DNA binding	3/313	123/18367	0.349603662494252	0.54619776448041	ANXA1/SMARCA1/YBX1	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	3/313	124/18367	0.354259887898264	0.552008132201264	NRP2/INSR/FLT1	3
GO:0003725	double-stranded RNA binding	2/313	74/18367	0.36029818302893	0.553086292336131	EIF4H/EIF4B	2
GO:0017022	myosin binding	2/313	74/18367	0.36029818302893	0.553086292336131	FUS/RHOA	2
GO:0004364	glutathione transferase activity	1/313	26/18367	0.360585969876187	0.553086292336131	GSTO1	1
GO:0042974	retinoic acid receptor binding	1/313	26/18367	0.360585969876187	0.553086292336131	FUS	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/313	26/18367	0.360585969876187	0.553086292336131	SLC26A2	1
GO:0099604	ligand-gated calcium channel activity	1/313	26/18367	0.360585969876187	0.553086292336131	MCOLN3	1
GO:0019207	kinase regulator activity	5/313	233/18367	0.365314560598064	0.554590183181626	IGF2/HSPB1/CALM1/CCNL1/CCNB1	5
GO:0001671	ATPase activator activity	1/313	27/18367	0.371497948035979	0.554590183181626	DNAJB4	1
GO:0004709	MAP kinase kinase kinase activity	1/313	27/18367	0.371497948035979	0.554590183181626	MAP3K4	1
GO:0016405	CoA-ligase activity	1/313	27/18367	0.371497948035979	0.554590183181626	SLC27A2	1
GO:0023026	MHC class II protein complex binding	1/313	27/18367	0.371497948035979	0.554590183181626	PKM	1
GO:0035255	ionotropic glutamate receptor binding	1/313	27/18367	0.371497948035979	0.554590183181626	FUS	1
GO:0045499	chemorepellent activity	1/313	27/18367	0.371497948035979	0.554590183181626	SEMA6D	1
GO:0051119	sugar transmembrane transporter activity	1/313	27/18367	0.371497948035979	0.554590183181626	SLC2A1	1
GO:0051393	alpha-actinin binding	1/313	27/18367	0.371497948035979	0.554590183181626	PDLIM2	1
GO:0051959	dynein light intermediate chain binding	1/313	27/18367	0.371497948035979	0.554590183181626	DYNLL1	1
GO:0015399	primary active transmembrane transporter activity	4/313	181/18367	0.371923807057287	0.554590183181626	ATP2B1/COX4I1/SLC26A2/NDUFB1	4
GO:0008187	poly-pyrimidine tract binding	1/313	28/18367	0.382224291670916	0.562825269485424	SSB	1
GO:0046875	ephrin receptor binding	1/313	28/18367	0.382224291670916	0.562825269485424	EFNB1	1
GO:0050681	androgen receptor binding	1/313	28/18367	0.382224291670916	0.562825269485424	DDX5	1
GO:0051861	glycolipid binding	1/313	28/18367	0.382224291670916	0.562825269485424	CLN3	1
GO:0070325	lipoprotein particle receptor binding	1/313	28/18367	0.382224291670916	0.562825269485424	CLU	1
GO:0001221	transcription coregulator binding	2/313	78/18367	0.384726167721808	0.565096540618815	NEK6/RPL23	2
GO:0015301	anion:anion antiporter activity	1/313	29/18367	0.392768148844536	0.569804038594659	SLC26A2	1
GO:0035250	UDP-galactosyltransferase activity	1/313	29/18367	0.392768148844536	0.569804038594659	B3GNT2	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/313	29/18367	0.392768148844536	0.569804038594659	PLEKHA2	1
GO:0051059	NF-kappaB binding	1/313	29/18367	0.392768148844536	0.569804038594659	ANXA4	1
GO:0070717	poly-purine tract binding	1/313	29/18367	0.392768148844536	0.569804038594659	HNRNPDL	1
GO:0005217	intracellular ligand-gated ion channel activity	1/313	30/18367	0.40313261440303	0.577725328183417	MCOLN3	1
GO:0005343	organic acid:sodium symporter activity	1/313	30/18367	0.40313261440303	0.577725328183417	SLC13A3	1
GO:0017147	Wnt-protein binding	1/313	30/18367	0.40313261440303	0.577725328183417	WLS	1
GO:0022829	wide pore channel activity	1/313	30/18367	0.40313261440303	0.577725328183417	GJA1	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/313	30/18367	0.40313261440303	0.577725328183417	HSD17B1	1
GO:0008237	metallopeptidase activity	4/313	190/18367	0.406607526636326	0.581016492801	ADAM12/CNDP2/ADAMTS6/ADAMTS1	4
GO:0004713	protein tyrosine kinase activity	3/313	136/18367	0.409649414332117	0.581016492801	NRP2/INSR/FLT1	3
GO:0000146	microfilament motor activity	1/313	31/18367	0.413320730872018	0.581016492801	MYH9	1
GO:0008157	protein phosphatase 1 binding	1/313	31/18367	0.413320730872018	0.581016492801	PPP1R15A	1
GO:0016878	acid-thiol ligase activity	1/313	31/18367	0.413320730872018	0.581016492801	SLC27A2	1
GO:0042910	xenobiotic transmembrane transporter activity	1/313	31/18367	0.413320730872018	0.581016492801	SLC2A1	1
GO:0043015	gamma-tubulin binding	1/313	31/18367	0.413320730872018	0.581016492801	PDE4B	1
GO:0090482	vitamin transmembrane transporter activity	1/313	31/18367	0.413320730872018	0.581016492801	SLC2A1	1
GO:0016746	acyltransferase activity	5/313	250/18367	0.422644850967726	0.588076894387351	CROT/ABHD8/SPTSSA/NMT1/PRDX6	5
GO:0001222	transcription corepressor binding	1/313	32/18367	0.423335489338263	0.588076894387351	NEK6	1
GO:0001223	transcription coactivator binding	1/313	32/18367	0.423335489338263	0.588076894387351	RPL23	1
GO:0008378	galactosyltransferase activity	1/313	32/18367	0.423335489338263	0.588076894387351	B3GNT2	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/313	32/18367	0.423335489338263	0.588076894387351	SMARCA1	1
GO:0050660	flavin adenine dinucleotide binding	2/313	85/18367	0.426453956962782	0.591015013296656	DHCR24/CYB5R1	2
GO:0045182	translation regulator activity	3/313	140/18367	0.427815806759027	0.5915105872795	EIF4H/EIF4B/EIF5A	3
GO:0042562	hormone binding	2/313	86/18367	0.43229608524026	0.593355628038268	INSR/NR3C1	2
GO:0004623	phospholipase A2 activity	1/313	33/18367	0.433179830316563	0.593355628038268	PRDX6	1
GO:0019956	chemokine binding	1/313	33/18367	0.433179830316563	0.593355628038268	ITGB1	1
GO:0140323	solute:anion antiporter activity	1/313	33/18367	0.433179830316563	0.593355628038268	SLC26A2	1
GO:0008194	UDP-glycosyltransferase activity	3/313	143/18367	0.441311068384645	0.60102948010706	GALNT11/EXTL2/B3GNT2	3
GO:0016229	steroid dehydrogenase activity	1/313	34/18367	0.442856644602093	0.60102948010706	HSD17B1	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/313	34/18367	0.442856644602093	0.60102948010706	HSPB1	1
GO:0008276	protein methyltransferase activity	2/313	88/18367	0.443884251012854	0.60102948010706	PRMT1/DNMT3A	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/313	88/18367	0.443884251012854	0.60102948010706	NDUFB1/CYB5R1	2
GO:0051117	ATPase binding	2/313	89/18367	0.449629091665217	0.607411777501864	CAV1/EZR	2
GO:0003712	transcription coregulator activity	9/313	489/18367	0.454854470638449	0.6130647212953	PAGE4/TLE4/FUS/MAGED1/HSPA1A/FHL2/ARID3A/BTG2/DNMT3A	9
GO:0000217	DNA secondary structure binding	1/313	36/18367	0.461719012691451	0.616672332143457	HMGB3	1
GO:0023023	MHC protein complex binding	1/313	36/18367	0.461719012691451	0.616672332143457	PKM	1
GO:0042805	actinin binding	1/313	36/18367	0.461719012691451	0.616672332143457	PDLIM2	1
GO:0043394	proteoglycan binding	1/313	36/18367	0.461719012691451	0.616672332143457	FN1	1
GO:0042277	peptide binding	6/313	321/18367	0.467369242468204	0.622806524465548	SLC7A5/ITM2B/INSR/DHCR24/CLTB/CLU	6
GO:0015035	protein-disulfide reductase activity	1/313	37/18367	0.470910106959498	0.623294501121673	PGK1	1
GO:0016409	palmitoyltransferase activity	1/313	37/18367	0.470910106959498	0.623294501121673	SPTSSA	1
GO:0030551	cyclic nucleotide binding	1/313	37/18367	0.470910106959498	0.623294501121673	PDE4B	1
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/313	38/18367	0.479944757069791	0.633817843872574	FKBP8	1
GO:0015081	sodium ion transmembrane transporter activity	3/313	152/18367	0.481012862837081	0.633817843872574	SLC6A8/SLC13A4/SLC13A3	3
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	1/313	39/18367	0.488825617511559	0.641243404708926	IQGAP2	1
GO:0019825	oxygen binding	1/313	39/18367	0.488825617511559	0.641243404708926	CYP19A1	1
GO:0005126	cytokine receptor binding	5/313	271/18367	0.492017254248235	0.642567988364103	MIF/VEGFB/PGF/TMBIM1/TGFBR3	5
GO:0035091	phosphatidylinositol binding	5/313	271/18367	0.492017254248235	0.642567988364103	PHLDA2/PFN1/SCIN/IQGAP2/EXOC1	5
GO:0004896	cytokine receptor activity	2/313	97/18367	0.494338241404516	0.643548166195852	CSF3R/CSF2RA	2
GO:0003925	G protein activity	1/313	40/18367	0.497555297875967	0.643548166195852	RHOA	1
GO:0004177	aminopeptidase activity	1/313	40/18367	0.497555297875967	0.643548166195852	DPP7	1
GO:0015144	carbohydrate transmembrane transporter activity	1/313	40/18367	0.497555297875967	0.643548166195852	SLC2A1	1
GO:0004386	helicase activity	3/313	156/18367	0.498230838345175	0.643548166195852	DDX5/ANXA1/SMARCA1	3
GO:0016859	cis-trans isomerase activity	1/313	41/18367	0.506136363613122	0.649486531956707	FKBP8	1
GO:0030020	extracellular matrix structural constituent conferring tensile strength	1/313	41/18367	0.506136363613122	0.649486531956707	COL14A1	1
GO:0048487	beta-tubulin binding	1/313	41/18367	0.506136363613122	0.649486531956707	RGS2	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1/313	42/18367	0.514571336776337	0.656770227870178	NDUFB1	1
GO:0019205	nucleobase-containing compound kinase activity	1/313	42/18367	0.514571336776337	0.656770227870178	N4BP2	1
GO:0140030	modification-dependent protein binding	3/313	160/18367	0.515157632047576	0.656770227870178	MORC4/AGL/BRD2	3
GO:0004725	protein tyrosine phosphatase activity	2/313	102/18367	0.521091131143877	0.660268319433874	PTPRA/PGP	2
GO:0030547	signaling receptor inhibitor activity	1/313	43/18367	0.522862696753909	0.660268319433874	LY6E	1
GO:0050136	NADH dehydrogenase (quinone) activity	1/313	43/18367	0.522862696753909	0.660268319433874	NDUFB1	1
GO:0022836	gated channel activity	6/313	340/18367	0.523051971058845	0.660268319433874	CLIC3/CLIC4/CLIC1/TMEM150C/MCOLN3/TMC5	6
GO:0008083	growth factor activity	3/313	162/18367	0.523506460400032	0.660268319433874	IGF2/VEGFB/PGF	3
GO:0033218	amide binding	7/313	400/18367	0.525044436073335	0.660793104374347	SLC7A5/ITM2B/DBI/INSR/DHCR24/CLTB/CLU	7
GO:0001784	phosphotyrosine residue binding	1/313	44/18367	0.531012880988576	0.665460823196321	PFN1	1
GO:0051879	Hsp90 protein binding	1/313	44/18367	0.531012880988576	0.665460823196321	NR3C1	1
GO:0003954	NADH dehydrogenase activity	1/313	45/18367	0.539024285684891	0.672638356500849	NDUFB1	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/313	45/18367	0.539024285684891	0.672638356500849	NDUFB1	1
GO:0140097	catalytic activity, acting on DNA	4/313	229/18367	0.549924598569155	0.684789827816559	ANXA1/SMARCA1/TOP2A/DNMT3A	4
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/313	47/18367	0.554640139250953	0.689204729997493	ATP2B1	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2/313	109/18367	0.55692511635351	0.690587144278353	ATP2B1/SLC26A2	2
GO:0016763	pentosyltransferase activity	1/313	49/18367	0.569728628462382	0.703213155946539	PARP1	1
GO:0032813	tumor necrosis factor receptor superfamily binding	1/313	49/18367	0.569728628462382	0.703213155946539	TMBIM1	1
GO:0004252	serine-type endopeptidase activity	3/313	174/18367	0.571883024954826	0.703213155946539	HTRA1/CTSC/PRSS8	3
GO:0004721	phosphoprotein phosphatase activity	3/313	174/18367	0.571883024954826	0.703213155946539	PHPT1/PTPRA/PGP	3
GO:0015267	channel activity	8/313	480/18367	0.575357555225316	0.705395590001433	FXYD3/CLIC3/CLIC4/CLIC1/GJA1/TMEM150C/MCOLN3/TMC5	8
GO:0015485	cholesterol binding	1/313	50/18367	0.577080683233169	0.705395590001433	CAV1	1
GO:0022803	passive transmembrane transporter activity	8/313	481/18367	0.577723306977496	0.705395590001433	FXYD3/CLIC3/CLIC4/CLIC1/GJA1/TMEM150C/MCOLN3/TMC5	8
GO:0106310	protein serine kinase activity	6/313	360/18367	0.579024174013224	0.705395590001433	NEK6/AAK1/STK24/STK17A/MAP3K4/PLK2	6
GO:0031406	carboxylic acid binding	3/313	176/18367	0.579645951715948	0.705395590001433	SIGLEC6/PYGL/P4HA1	3
GO:0003774	cytoskeletal motor activity	2/313	114/18367	0.581334458819113	0.705991744833934	MYH9/DYNLRB1	2
GO:0051018	protein kinase A binding	1/313	51/18367	0.584307507830429	0.708142226568154	EZR	1
GO:0004879	nuclear receptor activity	1/313	52/18367	0.591411228623674	0.709906666762498	NR3C1	1
GO:0017046	peptide hormone binding	1/313	52/18367	0.591411228623674	0.709906666762498	INSR	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/313	52/18367	0.591411228623674	0.709906666762498	AGL	1
GO:0098531	ligand-activated transcription factor activity	1/313	52/18367	0.591411228623674	0.709906666762498	NR3C1	1
GO:0048018	receptor ligand activity	8/313	487/18367	0.591789768048194	0.709906666762498	IGF2/FBN1/STC2/MIF/VEGFB/SEMA6D/PGF/FAM3B	8
GO:0017069	snRNA binding	1/313	53/18367	0.598393935991448	0.714916893101345	EIF5A	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/313	53/18367	0.598393935991448	0.714916893101345	SLC16A1	1
GO:0004175	endopeptidase activity	7/313	430/18367	0.601736955894993	0.717297336867073	HTRA1/ADAM12/ADAMTS6/CTSC/PRSS8/ADAMTS1/LGMN	7
GO:0004197	cysteine-type endopeptidase activity	2/313	119/18367	0.604743300003676	0.717297336867073	CTSC/LGMN	2
GO:0015459	potassium channel regulator activity	1/313	54/18367	0.605257684928583	0.717297336867073	CAV1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/313	54/18367	0.605257684928583	0.717297336867073	P4HA1	1
GO:0005216	ion channel activity	7/313	432/18367	0.606622369750707	0.717471035709169	FXYD3/CLIC3/CLIC4/CLIC1/TMEM150C/MCOLN3/TMC5	7
GO:0030546	signaling receptor activator activity	8/313	495/18367	0.610188004075419	0.720241952706256	IGF2/FBN1/STC2/MIF/VEGFB/SEMA6D/PGF/FAM3B	8
GO:0030170	pyridoxal phosphate binding	1/313	55/18367	0.612004495643231	0.720941295867726	PYGL	1
GO:0042054	histone methyltransferase activity	1/313	56/18367	0.618636354143868	0.724407182088943	PRMT1	1
GO:0045309	protein phosphorylated amino acid binding	1/313	56/18367	0.618636354143868	0.724407182088943	PFN1	1
GO:0070279	vitamin B6 binding	1/313	56/18367	0.618636354143868	0.724407182088943	PYGL	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/313	57/18367	0.625155212816413	0.730588135612832	NDUFB1	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/313	58/18367	0.631562990991643	0.73661505285956	GSTO1	1
GO:0001786	phosphatidylserine binding	1/313	60/18367	0.644052821235397	0.748219155241911	SCIN	1
GO:0032934	sterol binding	1/313	60/18367	0.644052821235397	0.748219155241911	CAV1	1
GO:0031072	heat shock protein binding	2/313	129/18367	0.648561425346632	0.75197377860072	HSPA1A/NR3C1	2
GO:0003730	mRNA 3'-UTR binding	3/313	201/18367	0.668948051959329	0.771057539342554	DDX5/YBX3/FUS	3
GO:0005244	voltage-gated ion channel activity	3/313	201/18367	0.668948051959329	0.771057539342554	CLIC3/CLIC4/CLIC1	3
GO:0022832	voltage-gated channel activity	3/313	201/18367	0.668948051959329	0.771057539342554	CLIC3/CLIC4/CLIC1	3
GO:0015085	calcium ion transmembrane transporter activity	2/313	135/18367	0.672956522613649	0.773233826609854	ATP2B1/MCOLN3	2
GO:0030145	manganese ion binding	1/313	65/18367	0.673461719950518	0.773233826609854	EXTL2	1
GO:0002039	p53 binding	1/313	66/18367	0.679046163271219	0.776617844983977	PTTG1IP	1
GO:0043022	ribosome binding	1/313	66/18367	0.679046163271219	0.776617844983977	EIF5A	1
GO:0003924	GTPase activity	5/313	337/18367	0.683582698826713	0.779897511648045	RAB17/RHOA/ARL4A/RHOB/RGS2	5
GO:0005543	phospholipid binding	7/313	466/18367	0.68456199239735	0.779897511648045	ANXA4/ANXA1/PHLDA2/PFN1/SCIN/IQGAP2/EXOC1	7
GO:0016782	transferase activity, transferring sulphur-containing groups	1/313	68/18367	0.689931052940774	0.782985337537795	MOCS2	1
GO:0019843	rRNA binding	1/313	68/18367	0.689931052940774	0.782985337537795	RPL23	1
GO:0003777	microtubule motor activity	1/313	69/18367	0.695234707808774	0.786799115807007	DYNLRB1	1
GO:0070851	growth factor receptor binding	2/313	141/18367	0.695963224678184	0.786799115807007	VEGFB/PGF	2
GO:0004860	protein kinase inhibitor activity	1/313	70/18367	0.700447929825161	0.790352166028774	HSPB1	1
GO:0140375	immune receptor activity	2/313	144/18367	0.706957210739982	0.795216946124635	CSF3R/CSF2RA	2
GO:0000049	tRNA binding	1/313	72/18367	0.710609197724002	0.795216946124635	SSB	1
GO:0003678	DNA helicase activity	1/313	72/18367	0.710609197724002	0.795216946124635	ANXA1	1
GO:0008235	metalloexopeptidase activity	1/313	72/18367	0.710609197724002	0.795216946124635	CNDP2	1
GO:0033293	monocarboxylic acid binding	1/313	73/18367	0.715560240146106	0.795216946124635	PYGL	1
GO:0035064	methylated histone binding	1/313	73/18367	0.715560240146106	0.795216946124635	MORC4	1
GO:0140034	methylation-dependent protein binding	1/313	73/18367	0.715560240146106	0.795216946124635	MORC4	1
GO:0140104	molecular carrier activity	1/313	73/18367	0.715560240146106	0.795216946124635	CLU	1
GO:0052689	carboxylic ester hydrolase activity	2/313	147/18367	0.717618462292081	0.796002399792911	ABHD8/PRDX6	2
GO:0019210	kinase inhibitor activity	1/313	74/18367	0.720426843668259	0.796861993613758	HSPB1	1
GO:0019842	vitamin binding	2/313	148/18367	0.721099223422976	0.796861993613758	PYGL/P4HA1	2
GO:0140677	molecular function activator activity	2/313	150/18367	0.727952534710239	0.802928919371406	CALM1/DNAJB4	2
GO:0003724	RNA helicase activity	1/313	77/18367	0.734534255092634	0.807165440764108	DDX5	1
GO:0038024	cargo receptor activity	1/313	77/18367	0.734534255092634	0.807165440764108	INSR	1
GO:0005319	lipid transporter activity	2/313	154/18367	0.74123247901226	0.812516953570319	SLC27A2/SLC2A1	2
GO:0001664	G protein-coupled receptor binding	4/313	295/18367	0.743461745424406	0.812516953570319	WLS/HSPA1A/CALM1/ARRDC3	4
GO:0008186	ATP-dependent activity, acting on RNA	1/313	79/18367	0.743542679073688	0.812516953570319	DDX5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/313	156/18367	0.747662736228133	0.815506206737723	PRMT1/DNMT3A	2
GO:0008013	beta-catenin binding	1/313	85/18367	0.768780204298849	0.836989908192277	GJA1	1
GO:0005525	GTP binding	5/313	377/18367	0.773053445579672	0.840089445473112	RAB17/INSR/RHOA/ARL4A/RHOB	5
GO:0016874	ligase activity	2/313	165/18367	0.774927185371624	0.840574792235518	SLC27A2/UBA5	2
GO:0051219	phosphoprotein binding	1/313	88/18367	0.780454578847926	0.844427828294754	PFN1	1
GO:0008081	phosphoric diester hydrolase activity	1/313	89/18367	0.784213959384093	0.844427828294754	PDE4B	1
GO:0015297	antiporter activity	1/313	89/18367	0.784213959384093	0.844427828294754	SLC26A2	1
GO:0043178	alcohol binding	1/313	89/18367	0.784213959384093	0.844427828294754	CAV1	1
GO:0003823	antigen binding	2/313	171/18367	0.791646159099809	0.850875160054356	SLC7A5/DHCR24	2
GO:0051213	dioxygenase activity	1/313	92/18367	0.795111421203551	0.853043036591788	P4HA1	1
GO:0072341	modified amino acid binding	1/313	93/18367	0.798620593579107	0.854984238616519	SCIN	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	1/313	94/18367	0.802069852318833	0.854984238616519	AGL	1
GO:0016410	N-acyltransferase activity	1/313	94/18367	0.802069852318833	0.854984238616519	NMT1	1
GO:0005096	GTPase activator activity	6/313	462/18367	0.802727137444712	0.854984238616519	EPS8L1/JUN/HACD3/ERRFI1/IQGAP2/RGS2	6
GO:0019001	guanyl nucleotide binding	5/313	398/18367	0.811638243087024	0.860266553468429	RAB17/INSR/RHOA/ARL4A/RHOB	5
GO:0032561	guanyl ribonucleotide binding	5/313	398/18367	0.811638243087024	0.860266553468429	RAB17/INSR/RHOA/ARL4A/RHOB	5
GO:0008170	N-methyltransferase activity	1/313	97/18367	0.812068257603475	0.860266553468429	PRMT1	1
GO:0003713	transcription coactivator activity	3/313	262/18367	0.826867762128035	0.874371834638083	PAGE4/FUS/MAGED1	3
GO:0004620	phospholipase activity	1/313	104/18367	0.833483189323426	0.879787810952506	PRDX6	1
GO:1990782	protein tyrosine kinase binding	1/313	105/18367	0.836337033803619	0.88094996470548	ITGB1	1
GO:0008234	cysteine-type peptidase activity	2/313	190/18367	0.837575518225923	0.88094996470548	CTSC/LGMN	2
GO:0030695	GTPase regulator activity	6/313	488/18367	0.841937911436572	0.882386885829432	EPS8L1/JUN/HACD3/ERRFI1/IQGAP2/RGS2	6
GO:0060589	nucleoside-triphosphatase regulator activity	6/313	488/18367	0.841937911436572	0.882386885829432	EPS8L1/JUN/HACD3/ERRFI1/IQGAP2/RGS2	6
GO:0016887	ATP hydrolysis activity	3/313	272/18367	0.845458818809274	0.884503098185901	DDX5/ATP2B1/HSPA1A	3
GO:0008047	enzyme activator activity	1/313	110/18367	0.849891299305316	0.885257567238689	CALM1	1
GO:0019902	phosphatase binding	2/313	196/18367	0.8500599732135	0.885257567238689	CTSC/PPP1R15A	2
GO:0016791	phosphatase activity	3/313	275/18367	0.850688935580812	0.885257567238689	PHPT1/PTPRA/PGP	3
GO:0099094	ligand-gated cation channel activity	1/313	113/18367	0.857480544006939	0.890751394038954	MCOLN3	1
GO:0046873	metal ion transmembrane transporter activity	5/313	430/18367	0.860198913994362	0.892002042856829	SLC6A8/ATP2B1/SLC13A4/SLC13A3/MCOLN3	5
GO:0005262	calcium channel activity	1/313	119/18367	0.871530649454831	0.902164415692259	MCOLN3	1
GO:0042578	phosphoric ester hydrolase activity	4/313	366/18367	0.873475480325014	0.902591329669181	PHPT1/PDE4B/PTPRA/PGP	4
GO:0008168	methyltransferase activity	2/313	214/18367	0.882452531050942	0.910270649367784	PRMT1/DNMT3A	2
GO:0004519	endonuclease activity	1/313	129/18367	0.89194573368032	0.916851722753418	N4BP2	1
GO:0016298	lipase activity	1/313	129/18367	0.89194573368032	0.916851722753418	PRDX6	1
GO:0015078	proton transmembrane transporter activity	1/313	130/18367	0.893800157704778	0.917157304683126	COX4I1	1
GO:0016779	nucleotidyltransferase activity	1/313	132/18367	0.897414369921307	0.919224935533637	UGP2	1
GO:0016741	transferase activity, transferring one-carbon groups	2/313	225/18367	0.898936439503183	0.919224935533637	PRMT1/DNMT3A	2
GO:0043177	organic acid binding	1/313	135/18367	0.902607077444729	0.921378801759005	P4HA1	1
GO:0005125	cytokine activity	2/313	235/18367	0.912031818534185	0.929286875687574	MIF/FAM3B	2
GO:0015276	ligand-gated ion channel activity	1/313	143/18367	0.915208678667663	0.929286875687574	MCOLN3	1
GO:0022834	ligand-gated channel activity	1/313	143/18367	0.915208678667663	0.929286875687574	MCOLN3	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	1/313	144/18367	0.916664982639185	0.929286875687574	AGL	1
GO:0008528	G protein-coupled peptide receptor activity	1/313	147/18367	0.920885987307789	0.931937755069698	LGR5	1
GO:0042393	histone binding	2/313	244/18367	0.922444331418733	0.931937755069698	MORC4/BRD2	2
GO:0019903	protein phosphatase binding	1/313	150/18367	0.924893842170794	0.932812453833215	PPP1R15A	1
GO:0001653	peptide receptor activity	1/313	153/18367	0.928699277986314	0.935049358519554	LGR5	1
GO:0004518	nuclease activity	1/313	210/18367	0.973494934563667	0.978478697027304	N4BP2	1
GO:0005085	guanyl-nucleotide exchange factor activity	1/313	223/18367	0.978859185623645	0.982194310617252	EPS8L1	1
GO:0005261	cation channel activity	1/313	335/18367	0.997007202339262	0.998702792819431	MCOLN3	1
GO:0140098	catalytic activity, acting on RNA	1/313	386/18367	0.998776244467466	0.998776244467466	DDX5	1