ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	55/859	332/18367	1.93021177896383e-16	1.68893530659335e-13	ITGB1/FLNB/F11R/PDLIM5/FXYD5/LASP1/CAPG/GPRC5A/BAIAP2L1/ARHGEF16/FLNA/PARVA/BZW2/LIMA1/PKP2/PHLDB2/GCN1/CNN2/VASP/CALD1/COBLL1/BMPR2/CTNNB1/PICALM/MYH9/RTN4/EIF4G2/CDC42EP1/SH3GL1/NDRG1/TBC1D10A/ARHGAP1/GOLGA3/MPRIP/IQGAP1/CTTN/TAGLN2/BSG/FMNL2/USO1/P2RX4/HDLBP/EZR/TJP2/VCL/JUP/LRRFIP1/KRT18/AHNAK/PKP3/EPN2/KTN1/EPS8L2/SH3GLB1/MACF1	55
GO:0019838	growth factor binding	28/859	141/18367	6.69564990699063e-11	2.9293468343084e-08	FLT1/HTRA1/HTRA4/IL6ST/IGFBP3/COL4A1/LTBP1/IL1R1/ENG/IL2RB/FGFR1/PTN/ACVRL1/IL1R2/ERBB2/COL6A1/PCSK6/CRIM1/LTBP3/INSR/LIFR/BMPR2/ERBB3/IGF2R/GPC1/S100A13/FURIN/TGFBR3	28
GO:0005178	integrin binding	27/859	144/18367	5.69270453094188e-10	1.65675672695247e-07	FN1/IGF2/TIMP2/FBN1/ITGB1/FBLN1/PTN/CD9/F11R/JAM2/P4HB/ADAM15/CD151/LAMB2/MMP14/PLPP3/ISG15/CALR/ADAM10/ADAM9/MYH9/LAMA5/PTK2/SEMA7A/ACTN4/ACTN1/ADAM17	27
GO:0003779	actin binding	52/859	440/18367	7.57374503749702e-10	1.65675672695247e-07	TPM1/ITGB1/FLNB/CORO6/SLC6A2/COTL1/P4HB/AFAP1/PDLIM5/AIF1L/FXYD5/TMSB10/LASP1/CAPG/LIMCH1/TPM2/BAIAP2L1/HIP1/KLHL5/FLNA/PARVA/LIMA1/SYNE1/CNN2/PALLD/MYO10/VASP/CALD1/COBLL1/MYH9/INF2/DAG1/DSTN/PTK2/EVL/MPRIP/MYO6/IQGAP1/ACTN4/CTTN/MYO9B/FMNL2/SSH2/INPPL1/MICAL3/EZR/VCL/GSN/ACTN1/MYO1C/EPS8L2/MACF1	52
GO:0016758	hexosyltransferase activity	29/859	197/18367	4.17056250986825e-08	7.29848439226943e-06	HEXB/MGAT5/CHPF/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/GALNT2/UGCG/MGAT4A/B4GALT1/COLGALT1/MGAT1/MGAT2/RPN2/GBA/CHPF2/RPN1/STT3A/B4GALT4/PYGL/MGAT4B/HEXA/B4GALT5/GALNT1/STT3B/EXT2	29
GO:0008194	UDP-glycosyltransferase activity	23/859	143/18367	2.05283837759337e-07	2.99372263399033e-05	HEXB/MGAT5/CHPF/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/GALNT2/UGCG/MGAT4A/B4GALT1/COLGALT1/MGAT1/MGAT2/CHPF2/B4GALT4/MGAT4B/HEXA/B4GALT5/GALNT1/EXT2	23
GO:0002020	protease binding	22/859	135/18367	2.97424768427948e-07	3.71780960534935e-05	FN1/TIMP3/SERPINE1/TIMP2/IL1R1/ITGB1/TIMP1/PSAP/SH3PXD2A/OS9/TNFAIP3/PINK1/LDLR/LRP1/RNF139/FURIN/TP53/AMFR/UBC/SERPINB6/SRI/DPP4	22
GO:0098631	cell adhesion mediator activity	14/859	59/18367	4.01674669368496e-07	4.39331669621793e-05	ITGB1/PDLIM5/ITGA1/ESAM/BAIAP2L1/PKP2/PALLD/DSG2/CDC42EP1/BSG/NPTN/JUP/KRT18/PKP3	14
GO:0030246	carbohydrate binding	33/859	271/18367	4.95013082623675e-07	4.81262719217462e-05	PRG2/EGLN3/ENG/PLOD3/PLOD2/PAM/PLOD1/GALNT7/GALNT6/P4HA2/LAYN/GALNT3/GALNT2/GAA/P3H1/OS9/MAN2A1/MGAT2/CANX/CALR/H6PD/LMAN1/CLN5/ATRN/P4HA1/PYGL/LGALS3/IGF2R/BSG/GALNT1/LMAN2/CHID1/GANAB	33
GO:0048029	monosaccharide binding	15/859	71/18367	7.80106581919997e-07	6.82593259179997e-05	EGLN3/ENG/PLOD3/PLOD2/PAM/PLOD1/P4HA2/P3H1/LMAN1/CLN5/P4HA1/PYGL/IGF2R/BSG/LMAN2	15
GO:0031418	L-ascorbic acid binding	8/859	20/18367	1.6893084116508e-06	0.000134376805472223	EGLN3/PLOD3/PLOD2/PAM/PLOD1/P4HA2/P3H1/P4HA1	8
GO:0098632	cell-cell adhesion mediator activity	12/859	49/18367	1.88824735098827e-06	0.000137684702676228	PDLIM5/ESAM/BAIAP2L1/PKP2/PALLD/DSG2/CDC42EP1/BSG/NPTN/JUP/KRT18/PKP3	12
GO:0016757	glycosyltransferase activity	31/859	270/18367	3.80907387535795e-06	0.000248806828149615	HEXB/MGAT5/CHPF/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/GALNT2/UGCG/MGAT4A/B4GALT1/COLGALT1/MGAT1/TNKS2/MGAT2/RPN2/GBA/CHPF2/RPN1/STT3A/ST3GAL6/B4GALT4/PYGL/MGAT4B/HEXA/B4GALT5/GALNT1/STT3B/EXT2	31
GO:0043394	proteoglycan binding	10/859	36/18367	3.98090925039384e-06	0.000248806828149615	FN1/PTPRF/PTN/SEMA5A/LPL/PTPRS/APOE/CTSL/CTSB/LRP1	10
GO:0031267	small GTPase binding	30/859	259/18367	4.55076216323013e-06	0.000265461126188424	ARHGDIB/CDC42EP5/ARHGEF16/RALBP1/FLNA/PKN1/SRGAP2/ABCA1/ARHGEF2/NCKAP1/SH3BP4/YIPF2/PICALM/INF2/CDC42SE1/NDRG1/ARHGAP1/IQGAP1/CDC42SE2/RHOBTB3/MYO9B/FMNL2/AP1G1/XPOT/MICAL3/SGSM3/ERRFI1/MYO1C/IPO7/ATP6AP1	30
GO:0008201	heparin binding	22/859	166/18367	1.0142815076479e-05	0.000515349818343015	FN1/SERPINE2/PRG2/AOC1/PTPRF/FSTL1/FBN1/FGFR1/SFRP1/PTN/ADAMTS1/LPL/PTPRS/CRISPLD2/APOE/PCSK6/PGF/NAV2/SOD3/LIPG/MDK/TGFBR3	22
GO:0005539	glycosaminoglycan binding	27/859	230/18367	1.05412188218451e-05	0.000515349818343015	FN1/SERPINE2/PRG2/AOC1/PTPRF/BGN/FSTL1/ENG/FBN1/FGFR1/SFRP1/PTN/ADAMTS1/SEMA5A/LPL/PTPRS/LAYN/CRISPLD2/APOE/PCSK6/PGF/NAV2/SOD3/LIPG/GNS/MDK/TGFBR3	27
GO:0051015	actin filament binding	26/859	217/18367	1.0601481977342e-05	0.000515349818343015	TPM1/FLNB/CORO6/COTL1/AIF1L/LASP1/CAPG/TPM2/HIP1/FLNA/LIMA1/SYNE1/MYO10/MYH9/DSTN/MPRIP/MYO6/IQGAP1/ACTN4/CTTN/FMNL2/EZR/GSN/ACTN1/MYO1C/MACF1	26
GO:0005518	collagen binding	13/859	69/18367	1.58849023222889e-05	0.000731541554315936	FN1/SPARC/ITGB1/ITGA1/SMAD3/COL6A1/SERPINH1/P3H4/CTSL/P3H1/CTSB/ADAM9/PPIB	13
GO:0051020	GTPase binding	31/859	291/18367	1.74188546299165e-05	0.000762074890058848	ARHGDIB/CDC42EP5/ARHGEF16/RALBP1/FLNA/PKN1/SRGAP2/ABCA1/ARHGEF2/NCKAP1/SH3BP4/YIPF2/PICALM/INF2/CDC42SE1/SH3GL1/NDRG1/ARHGAP1/IQGAP1/CDC42SE2/RHOBTB3/MYO9B/FMNL2/AP1G1/XPOT/MICAL3/SGSM3/ERRFI1/MYO1C/IPO7/ATP6AP1	31
GO:0019955	cytokine binding	19/859	139/18367	2.58879022159108e-05	0.00107866259232962	EBI3/IL6ST/LTBP1/IL1R1/ENG/IL2RB/NOG/ITGB1/IL18BP/ACVRL1/IL1R2/CCR1/CSF1R/LTBP3/LIFR/BMPR2/ACKR2/IFNAR1/TGFBR3	19
GO:0008375	acetylglucosaminyltransferase activity	10/859	44/18367	2.7659429038407e-05	0.00110009092766391	HEXB/MGAT5/B3GNT7/EXTL3/MGAT4A/MGAT1/MGAT2/MGAT4B/HEXA/EXT2	10
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	15/859	94/18367	2.9084793788978e-05	0.00110648672023286	HEXB/GAA/GM2A/MAN2A1/GBA/NAGLU/FUCA2/MAN1B1/HEXA/MAN1A2/MOGS/EDEM3/GLB1/GANAB/NEU1	15
GO:0019199	transmembrane receptor protein kinase activity	19/859	143/18367	3.86628731354831e-05	0.00136919685083425	FLT1/LTBP1/ENG/FGFR1/ACVRL1/ERBB2/PDGFRL/PTK2B/EPHB2/CSF1R/CRIM1/INSR/BMPR2/JAK1/PTK2/ERBB3/IGF2R/WEE1/TGFBR3	19
GO:0015035	protein-disulfide reductase activity	9/859	37/18367	3.91199100238358e-05	0.00136919685083425	QSOX1/P4HB/GLRX/PDIA5/TXN/PDIA3/DNAJC10/ERO1A/PDIA4	9
GO:0045294	alpha-catenin binding	5/859	10/18367	4.57832847272261e-05	0.0015407836206278	PKP2/CTNNB1/VCL/JUP/PKP3	5
GO:0042277	peptide binding	32/859	321/18367	4.79102026308412e-05	0.00155264545562911	LVRN/EBI3/ITM2B/HSPG2/HLA-G/PTGES/KDELR3/TGFB2/APOE/EPHB2/SCARB1/EDNRB/PPIC/TAP1/TAPBP/INSR/CLTB/CALR/PGRMC1/KDELR2/PICALM/PPIB/SEC61A1/LDLR/LRP1/KDELR1/ERAP1/PPP3CA/RXRA/FURIN/ITM2C/PIK3R1	32
GO:0015036	disulfide oxidoreductase activity	9/859	42/18367	0.000113658232616516	0.00355181976926614	QSOX1/P4HB/GLRX/PDIA5/TXN/PDIA3/DNAJC10/ERO1A/PDIA4	9
GO:0005024	transforming growth factor beta-activated receptor activity	5/859	12/18367	0.000133019275017566	0.00384583976650337	LTBP1/ENG/ACVRL1/BMPR2/TGFBR3	5
GO:0031543	peptidyl-proline dioxygenase activity	5/859	12/18367	0.000133019275017566	0.00384583976650337	EGLN3/P4HB/P4HA2/P3H1/P4HA1	5
GO:0016798	hydrolase activity, acting on glycosyl bonds	18/859	144/18367	0.000136252608870405	0.00384583976650337	HEXB/IL1R1/IL1RAP/GAA/GM2A/MAN2A1/GBA/CLN5/NAGLU/FUCA2/MAN1B1/HEXA/MAN1A2/MOGS/EDEM3/GLB1/GANAB/NEU1	18
GO:0016853	isomerase activity	19/859	158/18367	0.000150817434740101	0.00412391423117464	QSOX1/FKBP10/PTGES/HSD3B1/P4HB/DSEL/FKBP11/PPIC/PDIA5/FKBP9/PPIB/PGM3/MIF/PDIA3/FKBP14/ERO1A/PDIA4/DSE/GALE	19
GO:0001618	virus receptor activity	12/859	76/18367	0.000199056738123868	0.00521688001447405	ITGA5/ITGB1/F11R/PVR/SCARB1/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/BSG/DPP4	12
GO:0005080	protein kinase C binding	10/859	55/18367	0.000204670126016177	0.00521688001447405	SDC4/PDLIM5/FLNA/PKP2/HSPB1/PKN1/ADAM9/PRKCSH/HDAC5/YWHAG	10
GO:0038024	cargo receptor activity	12/859	77/18367	0.000225934574118519	0.00521688001447405	LGALS3BP/ABCA7/SCARB1/INSR/ABCA1/SCARB2/CD320/SCARA3/LRP10/LDLR/LRP1/ACKR2	12
GO:0140272	exogenous protein binding	12/859	77/18367	0.000225934574118519	0.00521688001447405	ITGA5/ITGB1/F11R/PVR/SCARB1/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/BSG/DPP4	12
GO:0003756	protein disulfide isomerase activity	6/859	20/18367	0.000226561646342873	0.00521688001447405	QSOX1/P4HB/PDIA5/PDIA3/ERO1A/PDIA4	6
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	6/859	20/18367	0.000226561646342873	0.00521688001447405	QSOX1/P4HB/PDIA5/PDIA3/ERO1A/PDIA4	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	10/859	57/18367	0.000277715039145711	0.00623078613467941	QSOX1/P4HB/GLRX/PDIA5/PCYOX1/TXN/PDIA3/DNAJC10/ERO1A/PDIA4	10
GO:0035259	glucocorticoid receptor binding	5/859	14/18367	0.000310897998153247	0.00680089370960227	NRIP1/SMAD3/NCOR2/ETS2/TACC1	5
GO:0017124	SH3 domain binding	16/859	130/18367	0.000375848567167129	0.00802115844563996	ADAM12/ADAM19/SH3BP5/AFAP1/ADAM15/VASP/ADAM10/ADAM9/CBLB/DNM2/SH3GL1/EVL/ARHGAP1/INPPL1/ERRFI1/ADAM17	16
GO:0005201	extracellular matrix structural constituent	19/859	172/18367	0.000451207009650128	0.00940014603437766	FN1/PRG2/SPARC/HSPG2/BGN/MFAP5/COL17A1/COL4A2/COL4A1/LTBP1/FBN1/FBLN1/MFAP2/COL27A1/COL6A1/LAMB2/LAMA5/LAMC1/FBN2	19
GO:0001540	amyloid-beta binding	12/859	84/18367	0.000515190607074926	0.0104835297951293	ITM2B/HSPG2/TGFB2/APOE/EPHB2/SCARB1/INSR/PGRMC1/PICALM/LDLR/LRP1/ITM2C	12
GO:0016860	intramolecular oxidoreductase activity	9/859	51/18367	0.000532135500185209	0.0105822400605013	QSOX1/PTGES/HSD3B1/P4HB/PDIA5/MIF/PDIA3/ERO1A/PDIA4	9
GO:0033218	amide binding	34/859	400/18367	0.000595297544608033	0.0115752300340451	LVRN/EBI3/ITM2B/HSPG2/HLA-G/FKBP10/PTGES/PSAP/KDELR3/TGFB2/APOE/EPHB2/SCARB1/EDNRB/PPIC/TAP1/TAPBP/INSR/CLTB/CALR/PGRMC1/KDELR2/PICALM/PPIB/SEC61A1/LDLR/LRP1/KDELR1/ERAP1/PPP3CA/RXRA/FURIN/ITM2C/PIK3R1	34
GO:1901681	sulfur compound binding	25/859	265/18367	0.000706149276141634	0.0134321873179115	FN1/SERPINE2/PRG2/AOC1/PTPRF/FSTL1/FBN1/FGFR1/SFRP1/PTGES/PTN/ADAMTS1/SEMA5A/LPL/PTPRS/CRISPLD2/APOE/PCSK6/PGF/NAV2/SOD3/LIPG/LRP1/MDK/TGFBR3	25
GO:0015924	mannosyl-oligosaccharide mannosidase activity	4/859	10/18367	0.000795476196225981	0.0146637311956331	MAN2A1/MAN1B1/MAN1A2/EDEM3	4
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	9/859	54/18367	0.000820769628194812	0.0146637311956331	EGLN3/P4HB/PLOD3/PLOD2/PLOD1/P4HA2/P3H1/TET3/P4HA1	9
GO:0008376	acetylgalactosaminyltransferase activity	7/859	34/18367	0.000848261049995354	0.0146637311956331	CHPF/GALNT7/GALNT6/GALNT3/GALNT2/CHPF2/GALNT1	7
GO:0034185	apolipoprotein binding	5/859	17/18367	0.000854686046831187	0.0146637311956331	LPL/SCARB1/CANX/ABCA1/LRP1	5
GO:0043395	heparan sulfate proteoglycan binding	5/859	17/18367	0.000854686046831187	0.0146637311956331	SEMA5A/LPL/PTPRS/APOE/LRP1	5
GO:0042974	retinoic acid receptor binding	6/859	26/18367	0.00105836030473177	0.0177653181236384	NRIP1/NCOR2/CTBP2/NCOA1/ACTN4/TACC1	6
GO:0004175	endopeptidase activity	35/859	430/18367	0.00107607069777467	0.0177653181236384	PAPPA/PAPPA2/HTRA1/ADAM12/HTRA4/ADAM19/SFRP1/PRSS8/ADAMTS1/MMP11/MMP2/ADAM15/TMEM59/CTSL/PCSK6/BMP1/MMP14/CTSB/ADAM10/PRSS22/ADAM9/HM13/CTSZ/CTSF/TPP2/ERAP1/CAPN2/PDIA3/FURIN/CTSH/DDI2/NCSTN/ADAM17/GPAA1/DPP4	35
GO:0098641	cadherin binding involved in cell-cell adhesion	5/859	18/18367	0.00113818315790173	0.0184427826511855	PDLIM5/BAIAP2L1/CDC42EP1/KRT18/PKP3	5
GO:0061134	peptidase regulator activity	22/859	230/18367	0.00120166968299324	0.0184812138549192	FN1/SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/FBLN1/TIMP1/CST6/PCSK1N/SERPINH1/RPS27L/CRIM1/PRSS22/PINK1/BST2/FURIN/CTSH/XIAP/SPINT1/SERPINB6	22
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4/859	11/18367	0.00120391907397759	0.0184812138549192	QSOX1/P4HB/PCYOX1/ERO1A	4
GO:0097493	structural molecule activity conferring elasticity	4/859	11/18367	0.00120391907397759	0.0184812138549192	FBN1/LAMC1/FBN2/AHNAK	4
GO:0022884	macromolecule transmembrane transporter activity	6/859	27/18367	0.00130752150812685	0.019725539993293	ABCA1/SEC61A1/TMED10/SEC61G/SLC15A3/SEC63	6
GO:0004860	protein kinase inhibitor activity	10/859	70/18367	0.00147669875344485	0.0209832099340513	SH3BP5/PRKAG2/CAMK2N1/CDKN1C/PARVA/HSPB1/PKIG/YWHAG/PRKAR2A/DNAJC3	10
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	5/859	19/18367	0.00148571504071054	0.0209832099340513	GALNT7/GALNT6/GALNT3/GALNT2/GALNT1	5
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	5/859	19/18367	0.00148571504071054	0.0209832099340513	LTBP1/ENG/ACVRL1/BMPR2/TGFBR3	5
GO:0030695	GTPase regulator activity	38/859	488/18367	0.0015107911152517	0.0209832099340513	SH3BP5/DOCK5/ASAP3/ARHGDIB/RASGRF2/IQSEC1/SYDE1/ARHGEF16/RALBP1/HERC1/RHOU/STXBP5/SEC23A/PLEKHG6/SRGAP2/ARHGEF2/RHOD/SH3BP4/TIAM1/NUCB2/CDC42SE1/NUCB1/TBC1D10A/ARHGAP1/TRIO/ARF4/IQGAP1/BCAR3/MYO9B/ARHGAP29/ARHGEF7/GNAQ/ARFGAP3/SGSM3/SH2D3A/ERRFI1/IPO7/EPS8L2	38
GO:0060589	nucleoside-triphosphatase regulator activity	38/859	488/18367	0.0015107911152517	0.0209832099340513	SH3BP5/DOCK5/ASAP3/ARHGDIB/RASGRF2/IQSEC1/SYDE1/ARHGEF16/RALBP1/HERC1/RHOU/STXBP5/SEC23A/PLEKHG6/SRGAP2/ARHGEF2/RHOD/SH3BP4/TIAM1/NUCB2/CDC42SE1/NUCB1/TBC1D10A/ARHGAP1/TRIO/ARF4/IQGAP1/BCAR3/MYO9B/ARHGAP29/ARHGEF7/GNAQ/ARFGAP3/SGSM3/SH2D3A/ERRFI1/IPO7/EPS8L2	38
GO:0001968	fibronectin binding	6/859	28/18367	0.00159908791295928	0.0215261834436826	FSTL3/IGFBP3/ITGB1/FBLN1/SDC4/CTSL	6
GO:0043236	laminin binding	6/859	28/18367	0.00159908791295928	0.0215261834436826	ITGB1/NTN4/ADAM9/DAG1/LGALS3/GPC1	6
GO:0004713	protein tyrosine kinase activity	15/859	136/18367	0.00175767491944315	0.0233025084017084	FLT1/FGFR1/ERBB2/PDGFRL/PTK2B/EPHB2/CSF1R/CRIM1/INSR/JAK1/PTK2/ERBB3/IGF2R/HIPK3/WEE1	15
GO:0030276	clathrin binding	10/859	72/18367	0.0018355397485151	0.0239716011932942	SYT8/HIP1/CLTB/PICALM/LDLR/LMBRD1/LRP1/GPR107/AP1G1/EPN2	10
GO:0004896	cytokine receptor activity	12/859	97/18367	0.00186950587830881	0.0240561418164736	EBI3/IL6ST/CSF2RB/IL1R1/IL2RB/IL1RAP/IL1R2/CCR1/IFNGR2/LIFR/ACKR2/IFNAR1	12
GO:0005520	insulin-like growth factor binding	6/859	29/18367	0.00193752854752327	0.0242191068440409	HTRA1/HTRA4/IGFBP3/CRIM1/INSR/IGF2R	6
GO:0035250	UDP-galactosyltransferase activity	6/859	29/18367	0.00193752854752327	0.0242191068440409	PLOD3/B3GNT7/B4GALT1/COLGALT1/B4GALT4/B4GALT5	6
GO:0004714	transmembrane receptor protein tyrosine kinase activity	14/859	124/18367	0.00197799178725751	0.0243116512570551	FLT1/FGFR1/ERBB2/PDGFRL/PTK2B/EPHB2/CSF1R/CRIM1/INSR/JAK1/PTK2/ERBB3/IGF2R/WEE1	14
GO:0005507	copper ion binding	9/859	61/18367	0.00200050158915196	0.0243116512570551	AOC1/PAM/SOD3/CUTA/GPC1/S100A13/P2RX4/TP53/ATOX1	9
GO:0004222	metalloendopeptidase activity	13/859	111/18367	0.00203354523999332	0.0243746860958104	PAPPA/PAPPA2/ADAM12/ADAM19/ADAMTS1/MMP11/MMP2/ADAM15/BMP1/MMP14/ADAM10/ADAM9/ADAM17	13
GO:0019210	kinase inhibitor activity	10/859	74/18367	0.00226171534125817	0.0267432557243365	SH3BP5/PRKAG2/CAMK2N1/CDKN1C/PARVA/HSPB1/PKIG/YWHAG/PRKAR2A/DNAJC3	10
GO:0005537	mannose binding	5/859	22/18367	0.00299482175556888	0.0344798557384575	LMAN1/CLN5/IGF2R/BSG/LMAN2	5
GO:0008320	protein transmembrane transporter activity	5/859	22/18367	0.00299482175556888	0.0344798557384575	ABCA1/SEC61A1/TMED10/SEC61G/SEC63	5
GO:0015293	symporter activity	15/859	144/18367	0.00307625007065474	0.034509215536191	SLC4A7/SLC6A2/SLC12A8/SLC39A8/SLC23A2/MFSD2A/SLC16A3/SLC1A5/SLC16A4/SLC17A5/SLC15A3/SLC6A8/SLC1A3/MFSD12/SLC16A1	15
GO:0016922	nuclear receptor binding	15/859	144/18367	0.00307625007065474	0.034509215536191	NRIP1/TCF7L2/HMGN3/SMAD3/NCOR2/PKN1/CALR/WIPI1/CTNNB1/CTBP2/NCOA1/ACTN4/RXRA/ETS2/TACC1	15
GO:0015926	glucosidase activity	4/859	14/18367	0.00326370551846978	0.0358837230673407	GAA/GBA/MOGS/GANAB	4
GO:0008378	galactosyltransferase activity	6/859	32/18367	0.00328079753758544	0.0358837230673407	PLOD3/B3GNT7/B4GALT1/COLGALT1/B4GALT4/B4GALT5	6
GO:0004620	phospholipase activity	12/859	104/18367	0.0033697476750371	0.0361153563031987	NOTUM/PLCL2/PLA2G7/LPL/GDPD3/PLCD3/CCR1/PLD3/MGLL/LIPG/PDIA3/LYPLA1	12
GO:0019887	protein kinase regulator activity	19/859	204/18367	0.0033845248192712	0.0361153563031987	IGF2/SH3BP5/PRKAG2/CAMK2N1/GPRC5A/CDKN1C/PARVA/GCN1/HSPB1/CCNG2/BMPR2/PKIG/CCNYL1/YWHAG/ERBB3/IQGAP1/PRKAR2A/CCNE1/DNAJC3	19
GO:0005096	GTPase activator activity	35/859	462/18367	0.00354826507232994	0.0374064088950445	SH3BP5/DOCK5/ASAP3/ARHGDIB/RASGRF2/IQSEC1/SYDE1/ARHGEF16/RALBP1/HERC1/RHOU/STXBP5/SEC23A/PLEKHG6/SRGAP2/ARHGEF2/RHOD/TIAM1/NUCB2/NUCB1/TBC1D10A/ARHGAP1/TRIO/ARF4/IQGAP1/BCAR3/MYO9B/ARHGAP29/ARHGEF7/GNAQ/ARFGAP3/SGSM3/SH2D3A/ERRFI1/EPS8L2	35
GO:0140103	catalytic activity, acting on a glycoprotein	5/859	23/18367	0.00368138758758171	0.0380163806335716	MGAT5/MGAT4A/MGAT1/MGAT2/MGAT4B	5
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	25/859	299/18367	0.00371056703179298	0.0380163806335716	NRIP1/TCF7L2/CITED2/HMGN3/IFI27/SMAD3/NOTCH2/ACTB/HSPB1/NCOR2/PKN1/CALR/MTDH/ANXA4/WIPI1/CTNNB1/HDAC5/CTBP2/NCOA1/ACTN4/RXRA/TP53/ETS2/TACC1/ATF4	25
GO:0031406	carboxylic acid binding	17/859	176/18367	0.00373646712512818	0.0380163806335716	EGLN3/PLOD3/PLOD2/PAM/PSAP/CRABP2/PLOD1/APOC1/P4HA2/P3H1/ACOX1/FABP5/P4HA1/PYGL/IGF2R/RXRA/SLC1A3	17
GO:0005085	guanyl-nucleotide exchange factor activity	20/859	223/18367	0.00412869726550871	0.0411997292683158	SH3BP5/DOCK5/RASGRF2/IQSEC1/ARHGEF16/HERC1/RHOU/PLEKHG6/ARHGEF2/RHOD/TIAM1/NUCB2/NUCB1/TBC1D10A/TRIO/ARF4/BCAR3/ARHGEF7/SH2D3A/EPS8L2	20
GO:0004559	alpha-mannosidase activity	4/859	15/18367	0.00428743165668843	0.0411997292683158	MAN2A1/MAN1B1/MAN1A2/EDEM3	4
GO:0015929	hexosaminidase activity	4/859	15/18367	0.00428743165668843	0.0411997292683158	HEXB/GM2A/NAGLU/HEXA	4
GO:0048185	activin binding	4/859	15/18367	0.00428743165668843	0.0411997292683158	FSTL3/ENG/ACVRL1/TGFBR3	4
GO:0050840	extracellular matrix binding	8/859	56/18367	0.00429574082551093	0.0411997292683158	SPARC/BGN/ITGB1/NTN4/ADAM9/DAG1/LGALS3/GPC1	8
GO:0043177	organic acid binding	14/859	135/18367	0.00433185724878292	0.0411997292683158	EGLN3/PLOD3/PLOD2/PAM/CRABP2/PLOD1/P4HA2/ID3/P3H1/FABP5/P4HA1/IGF2R/RXRA/SLC1A3	14
GO:0043495	protein-membrane adaptor activity	5/859	24/18367	0.00447380167750011	0.0414292276885154	LPL/SYNE1/MYH9/SUN2/JUP	5
GO:0050431	transforming growth factor beta binding	5/859	24/18367	0.00447380167750011	0.0414292276885154	LTBP1/ENG/ACVRL1/LTBP3/TGFBR3	5
GO:0030291	protein serine/threonine kinase inhibitor activity	6/859	34/18367	0.0044980304347531	0.0414292276885154	PRKAG2/CDKN1C/HSPB1/PKIG/YWHAG/PRKAR2A	6
GO:0000149	SNARE binding	12/859	110/18367	0.00532110524392589	0.0481903751940132	SYT8/SEC24D/STXBP5/ABCA1/TNFAIP2/SEC24A/SNAP23/PICALM/DAPK1/TMED10/TMED9/SEC22B	12
GO:0005160	transforming growth factor beta receptor binding	5/859	25/18367	0.00538042742150596	0.0481903751940132	ENG/SMAD3/TGFB1/TGFB2/TGFBR3	5
GO:0005159	insulin-like growth factor receptor binding	4/859	16/18367	0.00550747145074437	0.0481903751940132	IGF2/INSR/YWHAG/PIK3R1	4
GO:0008191	metalloendopeptidase inhibitor activity	4/859	16/18367	0.00550747145074437	0.0481903751940132	TIMP3/TIMP2/TIMP1/BST2	4
GO:0015923	mannosidase activity	4/859	16/18367	0.00550747145074437	0.0481903751940132	MAN2A1/MAN1B1/MAN1A2/EDEM3	4
GO:0140297	DNA-binding transcription factor binding	30/859	394/18367	0.00617704685863512	0.0535140198149082	NRIP1/TCF7L2/CITED2/HMGN3/IFI27/SMAD3/NOTCH2/ACTB/HSPB1/NCOR2/PKN1/WFS1/CALR/FHL2/MTDH/ANXA4/WIPI1/CTNNB1/HDAC5/CTBP2/NCOA1/ACTN4/RBFOX2/KLF5/RXRA/TP53/ETS2/TACC1/ATF4/SRI	30
GO:0019207	kinase regulator activity	20/859	233/18367	0.00668464220393213	0.0573437443964766	IGF2/SH3BP5/PRKAG2/CAMK2N1/GPRC5A/CDKN1C/PARVA/GCN1/HSPB1/CCNG2/BMPR2/PKIG/CCNYL1/YWHAG/ERBB3/IQGAP1/PRKAR2A/PIK3R1/CCNE1/DNAJC3	20
GO:0043531	ADP binding	6/859	37/18367	0.00690572552801903	0.0578258144072625	PRKAG2/TAP1/MYH9/MYO6/MYO9B/CYB5R3	6
GO:0071949	FAD binding	6/859	37/18367	0.00690572552801903	0.0578258144072625	QSOX1/ACOX1/CYB5R3/MICAL3/ERO1A/CYB5R1	6
GO:0046965	retinoid X receptor binding	4/859	17/18367	0.00693909772887149	0.0578258144072625	NRIP1/NCOR2/NCOA1/TACC1	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	6/859	38/18367	0.00788337380949526	0.0650750196538524	FKBP10/FKBP11/PPIC/FKBP9/PPIB/FKBP14	6
GO:0051117	ATPase binding	10/859	89/18367	0.00856866425987473	0.0696475847731945	WFS1/ABCA1/TOR1AIP2/PPP3CA/DNAJC10/EZR/NCSTN/PTPN3/ATOX1/SDF2L1	10
GO:0030228	lipoprotein particle receptor activity	4/859	18/18367	0.00859650189200573	0.0696475847731945	SCARB1/LRP10/LDLR/LRP1	4
GO:0004629	phospholipase C activity	5/859	28/18367	0.00886684294489048	0.070531705243447	NOTUM/PLCL2/PLCD3/CCR1/PDIA3	5
GO:0070325	lipoprotein particle receptor binding	5/859	28/18367	0.00886684294489048	0.070531705243447	HSPG2/APOE/HSP90B1/PICALM/LRP1	5
GO:0044325	transmembrane transporter binding	13/859	133/18367	0.00949961102737823	0.0733355297948318	TSPO/FLNA/PKP2/CTNNB1/PRKCSH/SH3GL1/HERPUD1/ACTN4/ITPR2/NPTN/ACTN1/FMR1/SRI	13
GO:0005522	profilin binding	3/859	10/18367	0.00955457188184094	0.0733355297948318	VASP/EVL/CTTN	3
GO:0035374	chondroitin sulfate binding	3/859	10/18367	0.00955457188184094	0.0733355297948318	PTN/PTPRS/MDK	3
GO:0070008	serine-type exopeptidase activity	3/859	10/18367	0.00955457188184094	0.0733355297948318	PRCP/CTSA/TPP2	3
GO:0004177	aminopeptidase activity	6/859	40/18367	0.0101306920452237	0.0770813525180066	LVRN/MMP14/TPP2/ERAP1/CTSH/DPP4	6
GO:0004866	endopeptidase inhibitor activity	16/859	180/18367	0.0104716081331062	0.0789884234178266	SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/PCSK1N/SERPINH1/CRIM1/BST2/FURIN/XIAP/SPINT1/SERPINB6	16
GO:0016859	cis-trans isomerase activity	6/859	41/18367	0.0114098855909678	0.0853303409580928	FKBP10/FKBP11/PPIC/FKBP9/PPIB/FKBP14	6
GO:0001972	retinoic acid binding	4/859	20/18367	0.0126395314390639	0.090986134009762	CRABP2/FABP5/IGF2R/RXRA	4
GO:0008603	cAMP-dependent protein kinase regulator activity	3/859	11/18367	0.0126860666847897	0.090986134009762	PRKAG2/PKIG/PRKAR2A	3
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	3/859	11/18367	0.0126860666847897	0.090986134009762	DSEL/DSE/GALE	3
GO:0022889	serine transmembrane transporter activity	3/859	11/18367	0.0126860666847897	0.090986134009762	SFXN3/SLC1A5/SERINC3	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/859	11/18367	0.0126860666847897	0.090986134009762	PKP2/DSG2/JUP	3
GO:0000146	microfilament motor activity	5/859	31/18367	0.0136634814420487	0.0948852877920052	MYO10/MYH9/MYO6/MYO9B/MYO1C	5
GO:0071813	lipoprotein particle binding	5/859	31/18367	0.0136634814420487	0.0948852877920052	LPL/APOE/SCARB1/ABCA1/LDLR	5
GO:0071814	protein-lipid complex binding	5/859	31/18367	0.0136634814420487	0.0948852877920052	LPL/APOE/SCARB1/ABCA1/LDLR	5
GO:0140318	protein transporter activity	5/859	31/18367	0.0136634814420487	0.0948852877920052	ABCA1/SEC61A1/TMED10/SEC61G/SEC63	5
GO:0016504	peptidase activator activity	6/859	43/18367	0.0143022962498726	0.098539442666445	FN1/FBLN1/RPS27L/PRSS22/PINK1/CTSH	6
GO:0030414	peptidase inhibitor activity	16/859	187/18367	0.0146792445930817	0.100346398585519	SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/PCSK1N/SERPINH1/CRIM1/BST2/FURIN/XIAP/SPINT1/SERPINB6	16
GO:0005385	zinc ion transmembrane transporter activity	4/859	21/18367	0.0150475013615739	0.102066385204474	SLC39A6/SLC30A2/SLC39A8/SLC39A7	4
GO:0001784	phosphotyrosine residue binding	6/859	44/18367	0.0159242779638993	0.10718264014163	CBLB/MAPK3/BCAR3/PIK3R1/PTPN3/SH2D3A	6
GO:0008022	protein C-terminus binding	16/859	189/18367	0.0160949695074473	0.107466881065134	FN1/HSPG2/FBLN1/ERBB2/PTK2B/RABAC1/TNFAIP3/TAF13/SASH1/SDC1/CTNNB1/PABPC1/SH3GL1/EZR/ID1/MYO1C	16
GO:0004867	serine-type endopeptidase inhibitor activity	10/859	98/18367	0.0162623723825652	0.107466881065134	SERPINE2/SERPINE1/SERPING1/TFPI/PCSK1N/SERPINH1/CRIM1/FURIN/SPINT1/SERPINB6	10
GO:0017166	vinculin binding	3/859	12/18367	0.0163349659219004	0.107466881065134	PXN/DAG1/ACTN1	3
GO:0030165	PDZ domain binding	9/859	84/18367	0.0164627446981888	0.107499265753099	F11R/ARHGEF16/CRIM1/ACOX1/PLEKHA1/TBC1D10A/ARHGAP29/ADAM17/TGFBR3	9
GO:0008237	metallopeptidase activity	16/859	190/18367	0.0168412729535763	0.10915639877318	PAPPA/PAPPA2/LVRN/ADAM12/ADAM19/ADAMTS1/MMP11/MMP2/ADAM15/CPM/BMP1/MMP14/ADAM10/ADAM9/ERAP1/ADAM17	16
GO:0140375	immune receptor activity	13/859	144/18367	0.0176040597273118	0.112939384837124	EBI3/IL6ST/CSF2RB/IL1R1/IL2RB/IL1RAP/IL1R2/CCR1/IFNGR2/LIFR/ACKR2/CTSH/IFNAR1	13
GO:0120020	cholesterol transfer activity	4/859	22/18367	0.0177258746073528	0.112939384837124	TSPO/APOE/ABCA1/NPC2	4
GO:0016298	lipase activity	12/859	129/18367	0.0178121544085979	0.112939384837124	NOTUM/PLCL2/PLA2G7/LPL/GDPD3/PLCD3/CCR1/PLD3/MGLL/LIPG/PDIA3/LYPLA1	12
GO:0061135	endopeptidase regulator activity	16/859	194/18367	0.0200961110030755	0.125675573799869	SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/PCSK1N/SERPINH1/CRIM1/BST2/FURIN/XIAP/SPINT1/SERPINB6	16
GO:0033293	monocarboxylic acid binding	8/859	73/18367	0.0203816923924397	0.125675573799869	PSAP/CRABP2/APOC1/ACOX1/FABP5/PYGL/IGF2R/RXRA	8
GO:0045159	myosin II binding	3/859	13/18367	0.0205094418303853	0.125675573799869	LIMCH1/STXBP5/GSN	3
GO:0017134	fibroblast growth factor binding	4/859	23/18367	0.0206826087167784	0.125675573799869	FGFR1/GPC1/S100A13/TGFBR3	4
GO:0050750	low-density lipoprotein particle receptor binding	4/859	23/18367	0.0206826087167784	0.125675573799869	HSPG2/APOE/HSP90B1/PICALM	4
GO:0120015	sterol transfer activity	4/859	23/18367	0.0206826087167784	0.125675573799869	TSPO/APOE/ABCA1/NPC2	4
GO:0005044	scavenger receptor activity	6/859	47/18367	0.021542382413012	0.128896563972945	LGALS3BP/SCARB1/SCARB2/SCARA3/LRP1/ACKR2	6
GO:0019842	vitamin binding	13/859	148/18367	0.021579612056043	0.128896563972945	EGLN3/PLOD3/PLOD2/PAM/CRABP2/PLOD1/P4HA2/P3H1/CD320/OPN3/LMBRD1/P4HA1/PYGL	13
GO:0051219	phosphoprotein binding	9/859	88/18367	0.0217009621303344	0.128896563972945	CBLB/PRKCSH/UBASH3B/IGF2R/MAPK3/BCAR3/PIK3R1/PTPN3/SH2D3A	9
GO:0019902	phosphatase binding	16/859	196/18367	0.0218932881712549	0.128896563972945	ITGA1/ERBB2/PXN/SMAD3/EIF4EBP1/HSP90B1/CTNNB1/JAK1/SH3GL1/PTK2/LGALS3/MAPK3/IQGAP1/TP53/JUP/PIK3R1	16
GO:0019905	syntaxin binding	8/859	74/18367	0.0219492434651072	0.128896563972945	SYT8/STXBP5/ABCA1/SNAP23/DAPK1/TMED10/TMED9/SEC22B	8
GO:0030674	protein-macromolecule adaptor activity	22/859	296/18367	0.022105293152081	0.128947543387139	LPL/HIP1/SYNE1/SNAP23/MYH9/CAV2/HERPUD1/IQGAP1/CDC42SE2/SUN2/ANKRD9/AP1G1/DDB1/TJP2/AMFR/JUP/NCSTN/SEC22B/PIK3R1/CUX1/OBSL1/FRMD4A	22
GO:0008238	exopeptidase activity	10/859	103/18367	0.0222930830114439	0.129181772417307	LVRN/PRCP/CPM/MMP14/CTSA/CTSZ/TPP2/ERAP1/CTSH/DPP4	10
GO:0015294	solute:cation symporter activity	10/859	104/18367	0.0236710652322982	0.135056928122934	SLC4A7/SLC6A2/SLC12A8/SLC39A8/SLC23A2/MFSD2A/SLC17A5/SLC15A3/SLC6A8/SLC1A3	10
GO:0019903	protein phosphatase binding	13/859	150/18367	0.0238018604237921	0.135056928122934	ITGA1/ERBB2/PXN/EIF4EBP1/HSP90B1/CTNNB1/JAK1/PTK2/LGALS3/IQGAP1/TP53/JUP/PIK3R1	13
GO:0140677	molecular function activator activity	13/859	150/18367	0.0238018604237921	0.135056928122934	PSAP/APOC1/SH3PXD2A/GUCA2A/SH3PXD2B/APOE/GM2A/KRTCAP2/CTSA/TOR1AIP2/BMPR2/DNAJC10/DDOST	13
GO:0001965	G-protein alpha-subunit binding	4/859	24/18367	0.023924370124634	0.135056928122934	SASH1/NUCB2/NUCB1/IGF2R	4
GO:0097718	disordered domain specific binding	5/859	36/18367	0.025054006304736	0.138749820146504	FN1/CTNNB1/GJA5/EZR/TP53	5
GO:0060090	molecular adaptor activity	26/859	369/18367	0.0250720899541908	0.138749820146504	LPL/HIP1/PKP2/SYNE1/WWC3/SASH1/DLGAP4/SNAP23/MYH9/CAV2/HERPUD1/IQGAP1/CDC42SE2/SUN2/ANKRD9/AP1G1/DDB1/TJP2/AMFR/JUP/NCSTN/SEC22B/PIK3R1/CUX1/OBSL1/FRMD4A	26
GO:0044548	S100 protein binding	3/859	14/18367	0.0252128244609076	0.138749820146504	IQGAP1/EZR/AHNAK	3
GO:0140666	annealing activity	3/859	14/18367	0.0252128244609076	0.138749820146504	TP53/FMR1/EIF4B	3
GO:0008514	organic anion transmembrane transporter activity	15/859	185/18367	0.0272887301010046	0.149220378734427	SLCO2A1/SLC4A7/SLC39A8/SLC35A3/SLC23A2/SLC7A1/MFSD2A/SFXN3/SLC16A3/SLC1A5/SLC6A8/SERINC3/SLC1A3/MFSD12/SLC16A1	15
GO:0008327	methyl-CpG binding	4/859	25/18367	0.0274565496871346	0.149220378734427	TET3/MBD2/ZBTB38/MBD3	4
GO:0051213	dioxygenase activity	9/859	92/18367	0.0280392983630226	0.151233582602988	EGLN3/P4HB/PLOD3/PLOD2/PLOD1/P4HA2/P3H1/TET3/P4HA1	9
GO:0051087	chaperone binding	10/859	107/18367	0.0281726559591853	0.151233582602988	FN1/GRN/CALR/SCARB2/DNAJC10/TP53/AMFR/SDF2L1/DNAJC3/ERP29	10
GO:0140359	ABC-type transporter activity	6/859	50/18367	0.0283653033806695	0.151339271085889	ABCA7/RALBP1/TAP1/TAPBP/ABCA1/LMBRD1	6
GO:0005041	low-density lipoprotein particle receptor activity	3/859	15/18367	0.0304441726619624	0.160473801682031	LRP10/LDLR/LRP1	3
GO:1904680	peptide transmembrane transporter activity	3/859	15/18367	0.0304441726619624	0.160473801682031	TAP1/TAPBP/SLC15A3	3
GO:0005501	retinoid binding	5/859	38/18367	0.0309209329589167	0.161046525827691	CRABP2/FABP5/OPN3/IGF2R/RXRA	5
GO:0019840	isoprenoid binding	5/859	38/18367	0.0309209329589167	0.161046525827691	CRABP2/FABP5/OPN3/IGF2R/RXRA	5
GO:0030145	manganese ion binding	7/859	65/18367	0.0316388613780968	0.16381067281559	MGAT5/GALNT3/GALNT2/B4GALT1/MGAT1/MGAT2/GALNT1	7
GO:0070851	growth factor receptor binding	12/859	141/18367	0.032889489201812	0.16926099198483	IL6ST/ITGA5/IL1R1/IL1RAP/GATA3/HIP1/PGF/ARF4/ERAP1/NPTN/NCSTN/ADAM17	12
GO:0008047	enzyme activator activity	10/859	110/18367	0.0332518219683904	0.16926099198483	PSAP/APOC1/SH3PXD2A/GUCA2A/SH3PXD2B/APOE/GM2A/KRTCAP2/CTSA/DDOST	10
GO:0015291	secondary active transmembrane transporter activity	18/859	240/18367	0.0332718749958752	0.16926099198483	SLCO2A1/SLC4A7/SLC6A2/SLC12A8/SLC39A8/SLC23A2/MFSD2A/SLC16A3/SLC1A5/SLC16A4/SLC35E1/SLC17A5/TMCO3/SLC15A3/SLC6A8/SLC1A3/MFSD12/SLC16A1	18
GO:0008236	serine-type peptidase activity	15/859	191/18367	0.0348350149088821	0.176031637046298	HTRA1/HTRA4/PRSS8/MMP11/MMP2/PRCP/PCSK6/BMP1/MMP14/CTSA/PRSS22/TPP2/FURIN/CTSH/DPP4	15
GO:0046982	protein heterodimerization activity	23/859	328/18367	0.0351826632193464	0.176031637046298	TPM1/EPAS1/ITGB1/P4HB/ERBB2/TPM2/HIP1/XBP1/SRGAP2C/TAF13/ATF3/MAPK6/CAV2/PAFAH1B2/ERBB3/HEXA/TP53/PIK3R1/KRT10/EXT2/FMR1/ATF4/SRI	23
GO:0045499	chemorepellent activity	4/859	27/18367	0.0354075064230268	0.176031637046298	SEMA5A/SEMA4C/SEMA7A/DPP4	4
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	4/859	27/18367	0.0354075064230268	0.176031637046298	ABCA7/MFSD2A/ATP11A/ABCA1	4
GO:0005521	lamin binding	3/859	16/18367	0.0361987960183974	0.177943519753358	IFI27/SYNE1/SUN2	3
GO:0016208	AMP binding	3/859	16/18367	0.0361987960183974	0.177943519753358	PRKAG2/PYGL/CYB5R3	3
GO:0097110	scaffold protein binding	7/859	67/18367	0.0365197914920279	0.178518533829745	IL6ST/PSAP/KRT8/CAV2/MAPK3/ITPR2/KRT18	7
GO:0042169	SH2 domain binding	5/859	40/18367	0.0375824251984467	0.182692344714672	AFAP1/SH3PXD2B/DAG1/PTK2/INPPL1	5
GO:0003713	transcription coactivator activity	19/859	262/18367	0.0392685773965146	0.1898342829942	NRIP1/CITED2/WWTR1/PKN1/TAF5L/MTDH/CTNNB1/CARM1/CTBP2/NCOA1/MAGED1/JADE1/ACTN4/JUP/ACTN1/TACC1/DDX17/RBPMS/MAML2	19
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4/859	28/18367	0.0398309503360496	0.1914949535387	SH3PXD2B/HIP1/SESTD1/WIPI1	4
GO:0017171	serine hydrolase activity	15/859	195/18367	0.0406421903298333	0.193899530246982	HTRA1/HTRA4/PRSS8/MMP11/MMP2/PRCP/PCSK6/BMP1/MMP14/CTSA/PRSS22/TPP2/FURIN/CTSH/DPP4	15
GO:0008083	growth factor activity	13/859	162/18367	0.040817767707134	0.193899530246982	IGF2/PTN/TIMP1/GDF15/CSH1/TGFB1/TGFB2/INHA/BMP1/GRN/PGF/CD320/MDK	13
GO:0030020	extracellular matrix structural constituent conferring tensile strength	5/859	41/18367	0.0412175001439299	0.193899530246982	COL17A1/COL4A2/COL4A1/COL27A1/COL6A1	5
GO:0030331	estrogen receptor binding	5/859	41/18367	0.0412175001439299	0.193899530246982	NRIP1/WIPI1/CTNNB1/NCOA1/TACC1	5
GO:0016854	racemase and epimerase activity	3/859	17/18367	0.042468731366153	0.198717325911143	DSEL/DSE/GALE	3
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	4/859	29/18367	0.0445542303720562	0.20736676369973	SH3PXD2A/HIP1/SESTD1/PLEKHA1	4
GO:0008307	structural constituent of muscle	5/859	42/18367	0.0450578469077167	0.208601143091281	TPM1/KRT19/TPM2/DAG1/CSRP1	5
GO:0030374	nuclear receptor coactivator activity	6/859	56/18367	0.0459392795983878	0.21045481491408	PKN1/CARM1/NCOA1/ACTN4/ACTN1/TACC1	6
GO:0045309	protein phosphorylated amino acid binding	6/859	56/18367	0.0459392795983878	0.21045481491408	CBLB/MAPK3/BCAR3/PIK3R1/PTPN3/SH2D3A	6
GO:0016209	antioxidant activity	8/859	86/18367	0.0477672141638112	0.216561204110543	PTGES/APOE/GLRX/PRDX4/SOD3/GPX8/TXN/GPX4	8
GO:0042562	hormone binding	8/859	86/18367	0.0477672141638112	0.216561204110543	EBI3/TTR/TSPO/EDNRB/INSR/CALR/CTSH/PIK3R1	8
GO:0032266	phosphatidylinositol-3-phosphate binding	5/859	43/18367	0.0491046298890119	0.219835612772243	SH3PXD2A/SH3PXD2B/HIP1/SESTD1/WIPI1	5
GO:0046527	glucosyltransferase activity	3/859	18/18367	0.0492431772609824	0.219835612772243	PLOD3/UGCG/GBA	3
GO:0098918	structural constituent of synapse	3/859	18/18367	0.0492431772609824	0.219835612772243	ACTB/CTBP2/ACTN1	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	13/859	170/18367	0.056079813903533	0.248468735458986	EGLN3/P4HB/PLOD3/PLOD2/PAM/PLOD1/P4HA2/P3H1/TET3/FADS3/CYP11A1/P4HA1/MICAL3	13
GO:0019888	protein phosphatase regulator activity	8/859	89/18367	0.05642257166323	0.248468735458986	IGFBP3/MGAT5/PTN/PPP1R14B/RCAN1/LGALS3/PPP1R15B/PPP2R5E	8
GO:0010314	phosphatidylinositol-5-phosphate binding	3/859	19/18367	0.0565088895501007	0.248468735458986	SH3PXD2A/SH3PXD2B/SESTD1	3
GO:1990782	protein tyrosine kinase binding	9/859	105/18367	0.0573388869961955	0.250857630608355	ITGB1/ARHGEF16/BMPR2/TIAM1/CBLB/YWHAG/TP53/TJP2/PIK3R1	9
GO:0005179	hormone activity	10/859	122/18367	0.0599150607004076	0.260824269218193	IGF2/FBN1/ADM/TTR/POMC/METRN/GUCA2A/CSH1/INHA/COPA	10
GO:0050699	WW domain binding	4/859	32/18367	0.060513258410383	0.261059997943332	DNM2/TCEAL4/NDFIP2/NDFIP1	4
GO:0042578	phosphoric ester hydrolase activity	24/859	366/18367	0.060565919522853	0.261059997943332	NOTUM/PTPRF/PLCL2/PTPRS/GDPD3/PLCD3/NT5DC2/CCR1/PLPP3/TNS3/PLD3/SGPP1/DUSP4/UBASH3B/PPP1CB/PDIA3/CTDSP1/PPP3CA/SSH2/INPPL1/PTPN3/PTP4A1/CTDNEP1/IMPA2	24
GO:0030546	signaling receptor activator activity	31/859	495/18367	0.0609739334904474	0.261530351981085	IGF2/TNFSF10/EBI3/FBN1/ADM/PTN/TTR/TIMP1/GDF15/SEMA5A/POMC/METRN/GUCA2A/CMTM3/CSH1/TGFB1/TGFB2/INHA/BMP1/GRN/FAM3C/SEMA4C/PGF/BMPR2/CD320/COPA/LGALS3/MIF/SEMA7A/MDK/DPP4	31
GO:0019208	phosphatase regulator activity	9/859	107/18367	0.0631304340877638	0.268151115664045	IGFBP3/MGAT5/PTN/BMPR2/PPP1R14B/RCAN1/LGALS3/PPP1R15B/PPP2R5E	9
GO:1902936	phosphatidylinositol bisphosphate binding	9/859	107/18367	0.0631304340877638	0.268151115664045	SH3PXD2A/SH3PXD2B/CAPG/HIP1/KCNJ2/SESTD1/WIPI1/PICALM/GSN	9
GO:0016018	cyclosporin A binding	3/859	20/18367	0.0642505409814601	0.270284727686431	PPIC/PPIB/PPP3CA	3
GO:0019211	phosphatase activator activity	3/859	20/18367	0.0642505409814601	0.270284727686431	IGFBP3/BMPR2/PPP2R5E	3
GO:0004252	serine-type endopeptidase activity	13/859	174/18367	0.0649966007122135	0.272114955134865	HTRA1/HTRA4/PRSS8/MMP11/MMP2/PCSK6/BMP1/MMP14/PRSS22/TPP2/FURIN/CTSH/DPP4	13
GO:0031625	ubiquitin protein ligase binding	20/859	297/18367	0.0657477014951187	0.273755010473276	DIO2/SMAD3/PTK2B/ISG15/WFS1/CALR/UBASH3B/RTN4/JAK1/PINK1/HM13/ERBB3/PRKAR2A/TP53/TMBIM6/VCL/UBC/UBE2K/UBE2A/PCBP2	20
GO:0043130	ubiquitin binding	8/859	92/18367	0.0660140653826986	0.273755010473276	SMAD3/HSPB1/TNFAIP3/ASCC2/DDI2/AMFR/UBE2A/FAAP20	8
GO:0044389	ubiquitin-like protein ligase binding	21/859	316/18367	0.0675403995772731	0.278763441651481	DIO2/SMAD3/PTK2B/ISG15/WFS1/CALR/UBASH3B/STAT2/RTN4/JAK1/PINK1/HM13/ERBB3/PRKAR2A/TP53/TMBIM6/VCL/UBC/UBE2K/UBE2A/PCBP2	21
GO:0015026	coreceptor activity	5/859	48/18367	0.0724419193988662	0.294089840249593	ENG/ITGB1/GPC4/LRP1/TGFBR3	5
GO:0043548	phosphatidylinositol 3-kinase binding	4/859	34/18367	0.0726167102901002	0.294089840249593	INSR/DNM2/PIK3R1/GSN	4
GO:0048018	receptor ligand activity	30/859	487/18367	0.0759576045063043	0.294089840249593	IGF2/TNFSF10/EBI3/FBN1/ADM/PTN/TTR/TIMP1/GDF15/SEMA5A/POMC/METRN/GUCA2A/CMTM3/CSH1/TGFB1/TGFB2/INHA/BMP1/GRN/FAM3C/SEMA4C/PGF/CD320/COPA/LGALS3/MIF/SEMA7A/MDK/DPP4	30
GO:0046332	SMAD binding	7/859	79/18367	0.0760519259800493	0.294089840249593	CITED2/ACVRL1/SMAD3/FLNA/CTNNB1/IPO7/TGFBR3	7
GO:0004465	lipoprotein lipase activity	2/859	10/18367	0.0766314098021795	0.294089840249593	LPL/LIPG	2
GO:0008190	eukaryotic initiation factor 4E binding	2/859	10/18367	0.0766314098021795	0.294089840249593	EIF4EBP1/EIF4EBP2	2
GO:0008239	dipeptidyl-peptidase activity	2/859	10/18367	0.0766314098021795	0.294089840249593	PRCP/DPP4	2
GO:0016176	superoxide-generating NADPH oxidase activator activity	2/859	10/18367	0.0766314098021795	0.294089840249593	SH3PXD2A/SH3PXD2B	2
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	2/859	10/18367	0.0766314098021795	0.294089840249593	CYB5R3/CYB5R1	2
GO:0017002	activin-activated receptor activity	2/859	10/18367	0.0766314098021795	0.294089840249593	ACVRL1/BMPR2	2
GO:0031419	cobalamin binding	2/859	10/18367	0.0766314098021795	0.294089840249593	CD320/LMBRD1	2
GO:0034713	type I transforming growth factor beta receptor binding	2/859	10/18367	0.0766314098021795	0.294089840249593	ENG/TGFB1	2
GO:0035612	AP-2 adaptor complex binding	2/859	10/18367	0.0766314098021795	0.294089840249593	HIP1/LMBRD1	2
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/859	10/18367	0.0766314098021795	0.294089840249593	DNM2/PIK3R1	2
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	2/859	10/18367	0.0766314098021795	0.294089840249593	LPL/LIPG	2
GO:0052813	phosphatidylinositol bisphosphate kinase activity	2/859	10/18367	0.0766314098021795	0.294089840249593	IPMK/PIK3CB	2
GO:0046943	carboxylic acid transmembrane transporter activity	12/859	163/18367	0.0807430866757141	0.30584216088081	SLC23A2/SLC7A1/MFSD2A/SFXN3/SLC16A3/SLC1A5/SLC38A10/SLC16A4/SERINC3/SLC1A3/MFSD12/SLC16A1	12
GO:0004602	glutathione peroxidase activity	3/859	22/18367	0.0810918643706832	0.30584216088081	PTGES/GPX8/GPX4	3
GO:0015296	anion:cation symporter activity	3/859	22/18367	0.0810918643706832	0.30584216088081	SLC6A2/SLC12A8/SLC39A8	3
GO:0030021	extracellular matrix structural constituent conferring compression resistance	3/859	22/18367	0.0810918643706832	0.30584216088081	PRG2/HSPG2/BGN	3
GO:0005342	organic acid transmembrane transporter activity	12/859	164/18367	0.0836184517304259	0.314017790833144	SLC23A2/SLC7A1/MFSD2A/SFXN3/SLC16A3/SLC1A5/SLC38A10/SLC16A4/SERINC3/SLC1A3/MFSD12/SLC16A1	12
GO:0005126	cytokine receptor binding	18/859	271/18367	0.0858439999288296	0.317945201176709	TNFSF10/IL6ST/ITGA5/ENG/IL1RAP/GATA3/SMAD3/CSH1/TGFB1/TGFB2/PGF/LIFR/JAK1/MIF/ERAP1/PIK3R1/ADAM17/TGFBR3	18
GO:0015248	sterol transporter activity	4/859	36/18367	0.0858500835923822	0.317945201176709	TSPO/APOE/ABCA1/NPC2	4
GO:0042805	actinin binding	4/859	36/18367	0.0858500835923822	0.317945201176709	PDLIM5/PALLD/DAG1/CSRP1	4
GO:0005516	calmodulin binding	14/859	201/18367	0.0895452933292197	0.317945201176709	RRAD/RASGRF2/PHKG1/CNN2/MYO10/WFS1/CALD1/MYH9/DAPK1/MYO6/IQGAP1/MYO9B/PPP3CA/MYO1C	14
GO:0005158	insulin receptor binding	3/859	23/18367	0.090153252718769	0.317945201176709	IGF2/LMBRD1/PIK3R1	3
GO:0030215	semaphorin receptor binding	3/859	23/18367	0.090153252718769	0.317945201176709	SEMA5A/SEMA4C/SEMA7A	3
GO:0000774	adenyl-nucleotide exchange factor activity	2/859	11/18367	0.0908414860504884	0.317945201176709	HSPH1/SIL1	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	2/859	11/18367	0.0908414860504884	0.317945201176709	SMYD3/GRHL2	2
GO:0002162	dystroglycan binding	2/859	11/18367	0.0908414860504884	0.317945201176709	DAG1/VCL	2
GO:0035197	siRNA binding	2/859	11/18367	0.0908414860504884	0.317945201176709	MBD2/FMR1	2
GO:0043560	insulin receptor substrate binding	2/859	11/18367	0.0908414860504884	0.317945201176709	INSR/PIK3R1	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/859	11/18367	0.0908414860504884	0.317945201176709	GLRX/TXN	2
GO:0047676	arachidonate-CoA ligase activity	2/859	11/18367	0.0908414860504884	0.317945201176709	ACSL4/ACSL3	2
GO:0048407	platelet-derived growth factor binding	2/859	11/18367	0.0908414860504884	0.317945201176709	COL4A1/COL6A1	2
GO:0052739	phosphatidylserine 1-acylhydrolase activity	2/859	11/18367	0.0908414860504884	0.317945201176709	LPL/LIPG	2
GO:0099186	structural constituent of postsynapse	2/859	11/18367	0.0908414860504884	0.317945201176709	ACTB/ACTN1	2
GO:0140036	ubiquitin-dependent protein binding	2/859	11/18367	0.0908414860504884	0.317945201176709	ANKRD13A/FAAP20	2
GO:0046915	transition metal ion transmembrane transporter activity	4/859	37/18367	0.0928755876428409	0.323769478834605	SLC39A6/SLC30A2/SLC39A8/SLC39A7	4
GO:0005496	steroid binding	8/859	100/18367	0.0962366187968208	0.33415492637785	TSPO/INSIG1/ABCA1/NPC2/SCARB2/PGRMC1/PAQR7/PGRMC2	8
GO:0015171	amino acid transmembrane transporter activity	7/859	84/18367	0.0978690012860448	0.337091631647993	SLC7A1/SFXN3/SLC1A5/SLC38A10/SERINC3/SLC1A3/MFSD12	7
GO:0022804	active transmembrane transporter activity	25/859	406/18367	0.0984788015870219	0.337091631647993	SLCO2A1/SLC4A7/SLC6A2/SLC12A8/ABCA7/SLC39A8/SLC23A2/MFSD2A/RALBP1/SLC16A3/TAP1/TAPBP/ABCA1/SLC1A5/ATP6V0E1/SLC16A4/SLC35E1/SLC17A5/LMBRD1/TMCO3/SLC15A3/SLC6A8/SLC1A3/MFSD12/SLC16A1	25
GO:0003707	steroid hormone receptor activity	3/859	24/18367	0.0996145216607882	0.337091631647993	PAQR7/PGRMC2/RXRA	3
GO:0004622	lysophospholipase activity	3/859	24/18367	0.0996145216607882	0.337091631647993	GDPD3/MGLL/LYPLA1	3
GO:0010857	calcium-dependent protein kinase activity	3/859	24/18367	0.0996145216607882	0.337091631647993	PRKD3/PKN1/PINK1	3
GO:0015295	solute:proton symporter activity	3/859	24/18367	0.0996145216607882	0.337091631647993	SLC39A8/SLC17A5/SLC15A3	3
GO:0015175	neutral amino acid transmembrane transporter activity	4/859	38/18367	0.100164370546832	0.337091631647993	SFXN3/SLC1A5/SERINC3/MFSD12	4
GO:0140303	intramembrane lipid transporter activity	4/859	38/18367	0.100164370546832	0.337091631647993	ABCA7/MFSD2A/ATP11A/ABCA1	4
GO:0050660	flavin adenine dinucleotide binding	7/859	85/18367	0.102605880563736	0.343985231774978	QSOX1/MAOA/ACOX1/CYB5R3/MICAL3/ERO1A/CYB5R1	7
GO:0004197	cysteine-type endopeptidase activity	9/859	119/18367	0.105464020574169	0.350473262563183	SFRP1/CTSL/CTSB/CTSZ/CTSF/CAPN2/PDIA3/CTSH/GPAA1	9
GO:0005095	GTPase inhibitor activity	2/859	12/18367	0.105742790076206	0.350473262563183	CDC42SE1/IQGAP1	2
GO:0035004	phosphatidylinositol 3-kinase activity	2/859	12/18367	0.105742790076206	0.350473262563183	IPMK/PIK3CB	2
GO:0031490	chromatin DNA binding	8/859	103/18367	0.109301415871735	0.358698368811886	HMGN3/SMAD3/ACTB/GRHL2/MBD2/ACTN4/GRHL1/MBD3	8
GO:0008266	poly(U) RNA binding	3/859	25/18367	0.109454245111741	0.358698368811886	HNRNPH1/PABPC1/FMR1	3
GO:0035035	histone acetyltransferase binding	3/859	25/18367	0.109454245111741	0.358698368811886	CITED2/EGR1/TP53	3
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	27/859	450/18367	0.111337902515079	0.363509942913039	EPAS1/GATA3/GCM1/GATA2/SMAD3/SOX4/FOSL2/ELF4/MLXIP/ATF3/GRHL2/CREB3L2/FOXJ3/GLIS3/KLF6/EGR1/FOSB/MYCN/KLF10/KLF5/ZNF292/TP53/TFAP2C/RREB1/ATF4/NFAT5/GRHL1	27
GO:1901981	phosphatidylinositol phosphate binding	12/859	173/18367	0.112347235282123	0.365441750453004	SH3PXD2A/SH3PXD2B/CAPG/HIP1/KCNJ2/SESTD1/MYO10/WIPI1/PICALM/IQGAP1/GSN/GOLPH3	12
GO:0017080	sodium channel regulator activity	4/859	40/18367	0.115500575521102	0.365809628186103	PRSS8/FXYD5/PKP2/PTPN3	4
GO:0031492	nucleosomal DNA binding	4/859	40/18367	0.115500575521102	0.365809628186103	HMGN3/ACTB/MBD2/MBD3	4
GO:0051082	unfolded protein binding	9/859	122/18367	0.118070121142306	0.365809628186103	SERPINH1/TAPBP/CANX/CALR/HSP90B1/LMAN1/PPIB/SIL1/PET100	9
GO:0004435	phosphatidylinositol phospholipase C activity	3/859	26/18367	0.119650456957645	0.365809628186103	PLCL2/PLCD3/CCR1	3
GO:0030371	translation repressor activity	3/859	26/18367	0.119650456957645	0.365809628186103	EIF4EBP1/EIF4EBP2/FMR1	3
GO:0051287	NAD binding	5/859	56/18367	0.120182965905449	0.365809628186103	HPGD/UGDH/CTBP2/CYB5R3/UXS1	5
GO:0045182	translation regulator activity	10/859	140/18367	0.120743250622331	0.365809628186103	IGF2BP2/RPS27L/GCN1/EIF4EBP1/EIF4EBP2/PABPC1/EIF4G2/FMR1/IGF2BP3/EIF4B	10
GO:0004859	phospholipase inhibitor activity	2/859	13/18367	0.121239762484537	0.365809628186103	APOC1/ANXA4	2
GO:0008035	high-density lipoprotein particle binding	2/859	13/18367	0.121239762484537	0.365809628186103	SCARB1/ABCA1	2
GO:0008494	translation activator activity	2/859	13/18367	0.121239762484537	0.365809628186103	RPS27L/PABPC1	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/859	13/18367	0.121239762484537	0.365809628186103	GLRX/TXN	2
GO:0031386	protein tag	2/859	13/18367	0.121239762484537	0.365809628186103	ISG15/UBC	2
GO:0031994	insulin-like growth factor I binding	2/859	13/18367	0.121239762484537	0.365809628186103	IGFBP3/INSR	2
GO:0034236	protein kinase A catalytic subunit binding	2/859	13/18367	0.121239762484537	0.365809628186103	PRKAR2A/EZR	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/859	13/18367	0.121239762484537	0.365809628186103	AMFR/UBE2K	2
GO:0052650	NADP-retinol dehydrogenase activity	2/859	13/18367	0.121239762484537	0.365809628186103	DHRS3/RDH10	2
GO:0060590	ATPase regulator activity	2/859	13/18367	0.121239762484537	0.365809628186103	HSPH1/SIL1	2
GO:0070679	inositol 1,4,5 trisphosphate binding	2/859	13/18367	0.121239762484537	0.365809628186103	PLCL2/ITPR2	2
GO:0072542	protein phosphatase activator activity	2/859	13/18367	0.121239762484537	0.365809628186103	IGFBP3/PPP2R5E	2
GO:0140035	ubiquitination-like modification-dependent protein binding	2/859	13/18367	0.121239762484537	0.365809628186103	ANKRD13A/FAAP20	2
GO:0140333	glycerophospholipid flippase activity	2/859	13/18367	0.121239762484537	0.365809628186103	MFSD2A/ATP11A	2
GO:0008081	phosphoric diester hydrolase activity	7/859	89/18367	0.122762561001781	0.367867263275884	NOTUM/PLCL2/GDPD3/PLCD3/CCR1/PLD3/PDIA3	7
GO:0043178	alcohol binding	7/859	89/18367	0.122762561001781	0.367867263275884	PLCL2/TSPO/CRABP2/ABCA1/NPC2/SCARB2/ITPR2	7
GO:0001216	DNA-binding transcription activator activity	27/859	456/18367	0.124376928793925	0.371432807831686	EPAS1/GATA3/GCM1/GATA2/SMAD3/SOX4/FOSL2/ELF4/MLXIP/ATF3/GRHL2/CREB3L2/FOXJ3/GLIS3/KLF6/EGR1/FOSB/MYCN/KLF10/KLF5/ZNF292/TP53/TFAP2C/RREB1/ATF4/NFAT5/GRHL1	27
GO:0015370	solute:sodium symporter activity	6/859	73/18367	0.125945244564932	0.372304354710527	SLC4A7/SLC6A2/SLC23A2/MFSD2A/SLC6A8/SLC1A3	6
GO:0106306	protein serine phosphatase activity	6/859	73/18367	0.125945244564932	0.372304354710527	DUSP4/PPP1CB/CTDSP1/PPP3CA/SSH2/CTDNEP1	6
GO:0106307	protein threonine phosphatase activity	6/859	73/18367	0.125945244564932	0.372304354710527	DUSP4/PPP1CB/CTDSP1/PPP3CA/SSH2/CTDNEP1	6
GO:0004190	aspartic-type endopeptidase activity	3/859	27/18367	0.130180825774472	0.377179544876367	HM13/DDI2/NCSTN	3
GO:0004683	calmodulin-dependent protein kinase activity	3/859	27/18367	0.130180825774472	0.377179544876367	PHKG1/PTK2B/DAPK1	3
GO:0043425	bHLH transcription factor binding	3/859	27/18367	0.130180825774472	0.377179544876367	SMAD3/FHL2/KLF5	3
GO:0048027	mRNA 5'-UTR binding	3/859	27/18367	0.130180825774472	0.377179544876367	IGF2BP2/FMR1/IGF2BP3	3
GO:0051393	alpha-actinin binding	3/859	27/18367	0.130180825774472	0.377179544876367	PDLIM5/PALLD/DAG1	3
GO:0070006	metalloaminopeptidase activity	3/859	27/18367	0.130180825774472	0.377179544876367	LVRN/MMP14/ERAP1	3
GO:0004707	MAP kinase activity	2/859	14/18367	0.137244252155142	0.392446799463233	MAPK6/MAPK3	2
GO:0005172	vascular endothelial growth factor receptor binding	2/859	14/18367	0.137244252155142	0.392446799463233	ITGA5/PGF	2
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	2/859	14/18367	0.137244252155142	0.392446799463233	HSD3B1/MIF	2
GO:0070411	I-SMAD binding	2/859	14/18367	0.137244252155142	0.392446799463233	SMAD3/CTNNB1	2
GO:0004180	carboxypeptidase activity	4/859	43/18367	0.140272236528053	0.396768358436326	PRCP/CPM/CTSA/CTSZ	4
GO:0003785	actin monomer binding	3/859	28/18367	0.141022810827083	0.396768358436326	TMSB10/LIMA1/COBLL1	3
GO:0008187	poly-pyrimidine tract binding	3/859	28/18367	0.141022810827083	0.396768358436326	HNRNPH1/PABPC1/FMR1	3
GO:0050681	androgen receptor binding	3/859	28/18367	0.141022810827083	0.396768358436326	PKN1/CALR/WIPI1	3
GO:0070001	aspartic-type peptidase activity	3/859	28/18367	0.141022810827083	0.396768358436326	HM13/DDI2/NCSTN	3
GO:0016791	phosphatase activity	17/859	275/18367	0.14776614875563	0.413968409210416	PTPRF/PTPRS/NT5DC2/PLPP3/TNS3/SGPP1/DUSP4/UBASH3B/PPP1CB/CTDSP1/PPP3CA/SSH2/INPPL1/PTPN3/PTP4A1/CTDNEP1/IMPA2	17
GO:0032934	sterol binding	5/859	60/18367	0.148419954400188	0.413968409210416	TSPO/INSIG1/ABCA1/NPC2/SCARB2	5
GO:0032182	ubiquitin-like protein binding	8/859	111/18367	0.148555520562366	0.413968409210416	SMAD3/HSPB1/TNFAIP3/ASCC2/DDI2/AMFR/UBE2A/FAAP20	8
GO:0051059	NF-kappaB binding	3/859	29/18367	0.152153800879586	0.415017451894065	NOTCH2/MTDH/ANXA4	3
GO:0051787	misfolded protein binding	3/859	29/18367	0.152153800879586	0.415017451894065	DNAJC10/SDF2L1/DNAJC3	3
GO:0070273	phosphatidylinositol-4-phosphate binding	3/859	29/18367	0.152153800879586	0.415017451894065	SH3PXD2A/SESTD1/GOLPH3	3
GO:0070717	poly-purine tract binding	3/859	29/18367	0.152153800879586	0.415017451894065	PABPC1/FMR1/RBPMS	3
GO:0004467	long-chain fatty acid-CoA ligase activity	2/859	15/18367	0.153675033615631	0.415017451894065	ACSL4/ACSL3	2
GO:0005161	platelet-derived growth factor receptor binding	2/859	15/18367	0.153675033615631	0.415017451894065	ITGA5/IL1R1	2
GO:0005545	1-phosphatidylinositol binding	2/859	15/18367	0.153675033615631	0.415017451894065	SCARB1/PICALM	2
GO:0050998	nitric-oxide synthase binding	2/859	15/18367	0.153675033615631	0.415017451894065	ACTB/DNM2	2
GO:0051371	muscle alpha-actinin binding	2/859	15/18367	0.153675033615631	0.415017451894065	PDLIM5/PALLD	2
GO:0070742	C2H2 zinc finger domain binding	2/859	15/18367	0.153675033615631	0.415017451894065	GATA2/MBD2	2
GO:0003712	transcription coregulator activity	28/859	489/18367	0.157148000305215	0.422396739403404	NRIP1/CITED2/PXN/IRF2BPL/WWTR1/NCOR2/PKN1/TAF5L/FHL2/MTDH/TLE3/CTNNB1/MED13L/ARID3A/CARM1/CTBP2/NCOA1/MAGED1/JADE1/ACTN4/RBFOX2/JUP/ACTN1/CAMTA1/TACC1/DDX17/RBPMS/MAML2	28
GO:0030971	receptor tyrosine kinase binding	6/859	78/18367	0.157515808999381	0.422396739403404	ARHGEF16/TIAM1/CBLB/YWHAG/TP53/PIK3R1	6
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/859	45/18367	0.157855695754186	0.422396739403404	PTK2B/JAK1/PTK2/WEE1	4
GO:0004864	protein phosphatase inhibitor activity	4/859	46/18367	0.166938342046235	0.436111649454186	MGAT5/PTN/PPP1R14B/LGALS3	4
GO:0061980	regulatory RNA binding	4/859	46/18367	0.166938342046235	0.436111649454186	SOX4/MBD2/FMR1/KCNQ1OT1	4
GO:0004698	calcium-dependent protein kinase C activity	2/859	16/18367	0.170457353272379	0.436111649454186	PRKD3/PKN1	2
GO:0005092	GDP-dissociation inhibitor activity	2/859	16/18367	0.170457353272379	0.436111649454186	ARHGDIB/SH3BP4	2
GO:0005402	carbohydrate:cation symporter activity	2/859	16/18367	0.170457353272379	0.436111649454186	SLC23A2/SLC17A5	2
GO:0008970	phospholipase A1 activity	2/859	16/18367	0.170457353272379	0.436111649454186	LPL/LIPG	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/859	16/18367	0.170457353272379	0.436111649454186	SLC1A5/SLC1A3	2
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/859	16/18367	0.170457353272379	0.436111649454186	AOC1/MAOA	2
GO:0035497	cAMP response element binding	2/859	16/18367	0.170457353272379	0.436111649454186	CREB5/CREB3L2	2
GO:0036122	BMP binding	2/859	16/18367	0.170457353272379	0.436111649454186	ENG/BMPR2	2
GO:0042577	lipid phosphatase activity	2/859	16/18367	0.170457353272379	0.436111649454186	PLPP3/SGPP1	2
GO:0050135	NAD(P)+ nucleosidase activity	2/859	16/18367	0.170457353272379	0.436111649454186	IL1R1/IL1RAP	2
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	2/859	16/18367	0.170457353272379	0.436111649454186	IL1R1/IL1RAP	2
GO:0070403	NAD+ binding	2/859	16/18367	0.170457353272379	0.436111649454186	HPGD/UXS1	2
GO:0140327	flippase activity	2/859	16/18367	0.170457353272379	0.436111649454186	MFSD2A/ATP11A	2
GO:0031210	phosphatidylcholine binding	3/859	31/18367	0.175192722350787	0.446920210078539	APOC1/ABCA1/SCARB2	3
GO:0008234	cysteine-type peptidase activity	12/859	190/18367	0.180167854205663	0.458275791947543	SFRP1/CTSL/PGPEP1/TNFAIP3/OTUD1/CTSB/CTSZ/CTSF/CAPN2/PDIA3/CTSH/GPAA1	12
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	6/859	82/18367	0.18499735052837	0.459613977597735	SH3PXD2A/CAPG/KCNJ2/SESTD1/PICALM/GSN	6
GO:0005319	lipid transporter activity	10/859	154/18367	0.185096891237771	0.459613977597735	SLCO2A1/TSPO/ABCA7/APOE/MFSD2A/ATP11A/GM2A/ABCA1/NPC2/FABP5	10
GO:0120013	lipid transfer activity	4/859	48/18367	0.185633886412996	0.459613977597735	TSPO/APOE/ABCA1/NPC2	4
GO:0004697	protein kinase C activity	2/859	17/18367	0.187522502859876	0.459613977597735	PRKD3/PKN1	2
GO:0005149	interleukin-1 receptor binding	2/859	17/18367	0.187522502859876	0.459613977597735	IL1RAP/ERAP1	2
GO:0005324	long-chain fatty acid transporter activity	2/859	17/18367	0.187522502859876	0.459613977597735	MFSD2A/FABP5	2
GO:0008484	sulfuric ester hydrolase activity	2/859	17/18367	0.187522502859876	0.459613977597735	ARSA/GNS	2
GO:0008525	phosphatidylcholine transporter activity	2/859	17/18367	0.187522502859876	0.459613977597735	ABCA7/ABCA1	2
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	2/859	17/18367	0.187522502859876	0.459613977597735	RPS27L/CTSH	2
GO:0015377	cation:chloride symporter activity	2/859	17/18367	0.187522502859876	0.459613977597735	SLC6A2/SLC12A8	2
GO:0030169	low-density lipoprotein particle binding	2/859	17/18367	0.187522502859876	0.459613977597735	SCARB1/LDLR	2
GO:0070064	proline-rich region binding	2/859	17/18367	0.187522502859876	0.459613977597735	BAIAP2L1/RABAC1	2
GO:0070628	proteasome binding	2/859	17/18367	0.187522502859876	0.459613977597735	WFS1/ID1	2
GO:0004721	phosphoprotein phosphatase activity	11/859	174/18367	0.192442061915775	0.470354201609785	PTPRF/PTPRS/DUSP4/UBASH3B/PPP1CB/CTDSP1/PPP3CA/SSH2/PTPN3/PTP4A1/CTDNEP1	11
GO:0030295	protein kinase activator activity	7/859	101/18367	0.193858516790408	0.472200161568227	IGF2/PRKAG2/GPRC5A/BMPR2/CCNYL1/ERBB3/IQGAP1	7
GO:0019212	phosphatase inhibitor activity	4/859	49/18367	0.195225795296595	0.472200161568227	MGAT5/PTN/PPP1R14B/LGALS3	4
GO:0043539	protein serine/threonine kinase activator activity	4/859	49/18367	0.195225795296595	0.472200161568227	IGF2/BMPR2/CCNYL1/IQGAP1	4
GO:0043022	ribosome binding	5/859	66/18367	0.195355952557369	0.472200161568227	GCN1/RPN2/SEC61A1/FMR1/TMCO1	5
GO:0019956	chemokine binding	3/859	33/18367	0.199119614454128	0.478652919360884	ITGB1/CCR1/ACKR2	3
GO:0031369	translation initiation factor binding	3/859	33/18367	0.199119614454128	0.478652919360884	EIF4EBP1/EIF4EBP2/FMR1	3
GO:0004725	protein tyrosine phosphatase activity	7/859	102/18367	0.200417540238589	0.480453007421275	PTPRF/PTPRS/DUSP4/UBASH3B/SSH2/PTPN3/PTP4A1	7
GO:0048038	quinone binding	2/859	18/18367	0.204807418559737	0.484717740947439	AOC1/VKORC1	2
GO:0055102	lipase inhibitor activity	2/859	18/18367	0.204807418559737	0.484717740947439	APOC1/ANXA4	2
GO:0005048	signal sequence binding	4/859	50/18367	0.204966359029203	0.484717740947439	KDELR3/KDELR2/SEC61A1/KDELR1	4
GO:0015485	cholesterol binding	4/859	50/18367	0.204966359029203	0.484717740947439	TSPO/ABCA1/NPC2/SCARB2	4
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/859	50/18367	0.204966359029203	0.484717740947439	CDKN1C/CCNG2/CCNYL1/CCNE1	4
GO:0008013	beta-catenin binding	6/859	85/18367	0.206749461578828	0.487616654667048	TCF7L2/PXN/SMAD3/CTNNB1/CARM1/VCL	6
GO:0015020	glucuronosyltransferase activity	3/859	34/18367	0.211361830986131	0.495821989578724	CHPF/CHPF2/EXT2	3
GO:0035198	miRNA binding	3/859	34/18367	0.211361830986131	0.495821989578724	SOX4/FMR1/KCNQ1OT1	3
GO:0004601	peroxidase activity	4/859	51/18367	0.214844969870823	0.502645317211149	PTGES/PRDX4/GPX8/GPX4	4
GO:0008509	anion transmembrane transporter activity	18/859	314/18367	0.218849025767036	0.510647726789751	SLCO2A1/SLC4A7/SLC6A2/SLC12A8/SLC39A8/SLC35A3/SLC23A2/SLC7A1/MFSD2A/SFXN3/SLC16A3/CLIC4/SLC1A5/SLC6A8/SERINC3/SLC1A3/MFSD12/SLC16A1	18
GO:0004745	NAD-retinol dehydrogenase activity	2/859	19/18367	0.222254304325577	0.514477556309206	DHRS3/RDH10	2
GO:0016918	retinal binding	2/859	19/18367	0.222254304325577	0.514477556309206	CRABP2/OPN3	2
GO:0035615	clathrin adaptor activity	2/859	19/18367	0.222254304325577	0.514477556309206	HIP1/AP1G1	2
GO:0042887	amide transmembrane transporter activity	3/859	35/18367	0.223761849776041	0.516600576659724	TAP1/TAPBP/SLC15A3	3
GO:0017046	peptide hormone binding	4/859	52/18367	0.224851034262591	0.517749092052019	EBI3/EDNRB/INSR/PIK3R1	4
GO:0015631	tubulin binding	21/859	375/18367	0.226963284410199	0.521241138737334	KIF21A/SLC6A2/MAPRE2/MAP7D3/ARHGEF2/CCDC69/TIAM1/DNM2/DAG1/NDRG1/SUN2/CCSAP/ARL8B/REEP3/EZR/ARHGEF7/HSPH1/FMR1/MAP4/MACF1/GPAA1	21
GO:0004857	enzyme inhibitor activity	5/859	70/18367	0.229148639559447	0.524882355011823	APOC1/ANGPTL4/ANXA4/PRPSAP1/TMBIM6	5
GO:0019209	kinase activator activity	7/859	107/18367	0.234424740875894	0.535422531693683	IGF2/PRKAG2/GPRC5A/BMPR2/CCNYL1/ERBB3/IQGAP1	7
GO:1901505	carbohydrate derivative transmembrane transporter activity	4/859	53/18367	0.234974002480428	0.535422531693683	SLC35A3/MFSD2A/SLC17A5/SLC15A3	4
GO:0042605	peptide antigen binding	3/859	36/18367	0.236299283065464	0.535652519902283	HLA-G/TAP1/TAPBP	3
GO:0061631	ubiquitin conjugating enzyme activity	3/859	36/18367	0.236299283065464	0.535652519902283	UBE2Q2/UBE2K/UBE2A	3
GO:0016505	peptidase activator activity involved in apoptotic process	2/859	20/18367	0.239810278030479	0.536659829352095	RPS27L/CTSH	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/859	20/18367	0.239810278030479	0.536659829352095	AOC1/MAOA	2
GO:0042288	MHC class I protein binding	2/859	20/18367	0.239810278030479	0.536659829352095	TAP1/TAPBP	2
GO:0050145	nucleoside monophosphate kinase activity	2/859	20/18367	0.239810278030479	0.536659829352095	TJP2/CMPK1	2
GO:0140312	cargo adaptor activity	2/859	20/18367	0.239810278030479	0.536659829352095	HIP1/AP1G1	2
GO:0042626	ATPase-coupled transmembrane transporter activity	7/859	109/18367	0.24853514209965	0.554287597042505	ABCA7/RALBP1/TAP1/TAPBP/ABCA1/ATP6V0E1/LMBRD1	7
GO:0042056	chemoattractant activity	3/859	37/18367	0.248954315014519	0.554287597042505	PGF/LGALS3/MIF	3
GO:0052689	carboxylic ester hydrolase activity	9/859	147/18367	0.25063833454388	0.556620666816993	NOTUM/PLA2G7/LPL/GDPD3/H6PD/MGLL/LIPG/PAFAH1B2/LYPLA1	9
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	4/859	55/18367	0.255528833894417	0.564963362380242	PTGES/PRDX4/GPX8/GPX4	4
GO:0047485	protein N-terminus binding	7/859	110/18367	0.255686276002944	0.564963362380242	PDLIM5/GLRX/NCOR2/ACOX1/NCOA1/TP53/ID1	7
GO:0001848	complement binding	2/859	21/18367	0.257427039130027	0.565951405122546	CD59/CALR	2
GO:0140416	transcription regulator inhibitor activity	2/859	21/18367	0.257427039130027	0.565951405122546	ID3/ID1	2
GO:0005504	fatty acid binding	3/859	39/18367	0.274540987020802	0.592238270273952	APOC1/ACOX1/FABP5	3
GO:0050997	quaternary ammonium group binding	3/859	39/18367	0.274540987020802	0.592238270273952	APOC1/ABCA1/SCARB2	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/859	39/18367	0.274540987020802	0.592238270273952	UBE2Q2/UBE2K/UBE2A	3
GO:0008093	cytoskeletal anchor activity	2/859	22/18367	0.275060556605961	0.592238270273952	JUP/OBSL1	2
GO:0008106	alcohol dehydrogenase (NADP+) activity	2/859	22/18367	0.275060556605961	0.592238270273952	DHRS3/RDH10	2
GO:0015106	bicarbonate transmembrane transporter activity	2/859	22/18367	0.275060556605961	0.592238270273952	SLC4A7/SLC39A8	2
GO:0015645	fatty acid ligase activity	2/859	22/18367	0.275060556605961	0.592238270273952	ACSL4/ACSL3	2
GO:0017075	syntaxin-1 binding	2/859	22/18367	0.275060556605961	0.592238270273952	STXBP5/DAPK1	2
GO:0005506	iron ion binding	9/859	151/18367	0.27547540114457	0.592238270273952	EGLN3/PLOD3/PLOD2/PLOD1/P4HA2/P3H1/CYP11A1/CALR/P4HA1	9
GO:0005548	phospholipid transporter activity	4/859	57/18367	0.276426938828051	0.592827381065061	ABCA7/MFSD2A/ATP11A/ABCA1	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	4/859	58/18367	0.286979529246181	0.609840134358778	MFSD2A/SLC16A3/SLC16A4/SLC16A1	4
GO:0043014	alpha-tubulin binding	3/859	40/18367	0.287436155520778	0.609840134358778	SLC6A2/ARL8B/HSPH1	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/859	40/18367	0.287436155520778	0.609840134358778	RPS27L/CTSH/XIAP	3
GO:0008017	microtubule binding	15/859	271/18367	0.287844543417343	0.609840134358778	KIF21A/MAPRE2/MAP7D3/ARHGEF2/CCDC69/TIAM1/DNM2/NDRG1/SUN2/CCSAP/REEP3/EZR/FMR1/MAP4/MACF1	15
GO:0035091	phosphatidylinositol binding	15/859	271/18367	0.287844543417343	0.609840134358778	SH3PXD2A/SH3PXD2B/CAPG/HIP1/KCNJ2/SCARB1/SESTD1/MYO10/WIPI1/PICALM/IQGAP1/ITPR2/GSN/GOLPH3/GPAA1	15
GO:0008143	poly(A) binding	2/859	23/18367	0.292670776023789	0.611185988116504	PABPC1/RBPMS	2
GO:0008483	transaminase activity	2/859	23/18367	0.292670776023789	0.611185988116504	GFPT1/BCAT1	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/859	23/18367	0.292670776023789	0.611185988116504	PRKD3/PKN1	2
GO:0016493	C-C chemokine receptor activity	2/859	23/18367	0.292670776023789	0.611185988116504	CCR1/ACKR2	2
GO:0016849	phosphorus-oxygen lyase activity	2/859	23/18367	0.292670776023789	0.611185988116504	ADCY7/RNASET2	2
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	2/859	23/18367	0.292670776023789	0.611185988116504	TNFAIP3/FAAP20	2
GO:0001221	transcription coregulator binding	5/859	78/18367	0.300908028357811	0.62689172574544	EPAS1/SMAD3/CTNNB1/CTBP2/MAFK	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	8/859	136/18367	0.304322767927819	0.632499814576822	HPGD/HSD3B1/UGDH/DHRS3/H6PD/CTBP2/VKORC1/RDH10	8
GO:0004722	protein serine/threonine phosphatase activity	6/859	98/18367	0.309372052195406	0.640197350299442	DUSP4/PPP1CB/CTDSP1/PPP3CA/SSH2/CTDNEP1	6
GO:0016769	transferase activity, transferring nitrogenous groups	2/859	24/18367	0.310221344602244	0.640197350299442	GFPT1/BCAT1	2
GO:0019957	C-C chemokine binding	2/859	24/18367	0.310221344602244	0.640197350299442	CCR1/ACKR2	2
GO:0019894	kinesin binding	3/859	42/18367	0.313344060085693	0.645120123705839	ACTB/AP1G1/KTN1	3
GO:0003924	GTPase activity	18/859	337/18367	0.314625731966353	0.646238299226664	RRAD/TUBB2A/ARHGDIB/RHOU/ATL3/RAB8B/RHOD/DNM2/ARF4/RHOBTB3/SAR1A/ARL8B/TUBB6/GNAQ/RHEB/ARL5B/RHOC/RND3	18
GO:0015179	L-amino acid transmembrane transporter activity	4/859	61/18367	0.318934748201013	0.653554811887321	SLC7A1/SLC1A5/SERINC3/SLC1A3	4
GO:0005112	Notch binding	2/859	25/18367	0.327679353253591	0.66678938162068	NCOR2/ADAM17	2
GO:0034237	protein kinase A regulatory subunit binding	2/859	25/18367	0.327679353253591	0.66678938162068	PRRC1/EZR	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/859	25/18367	0.327679353253591	0.66678938162068	MEX3D/ZFP36L1	2
GO:0005543	phospholipid binding	24/859	466/18367	0.342288952288432	0.693995879965836	SYT8/PSAP/APOC1/PLA2G7/SH3PXD2A/SH3PXD2B/CAPG/APOE/HIP1/KCNJ2/SCARB1/SESTD1/MYO10/ABCA1/SCARB2/ANXA4/WIPI1/PICALM/IQGAP1/ITPR2/GSN/GOLPH3/EPN2/GPAA1	24
GO:0001637	G protein-coupled chemoattractant receptor activity	2/859	26/18367	0.345015094611587	0.693995879965836	CCR1/ACKR2	2
GO:0004806	triglyceride lipase activity	2/859	26/18367	0.345015094611587	0.693995879965836	LPL/LIPG	2
GO:0004950	chemokine receptor activity	2/859	26/18367	0.345015094611587	0.693995879965836	CCR1/ACKR2	2
GO:0099604	ligand-gated calcium channel activity	2/859	26/18367	0.345015094611587	0.693995879965836	ITPR2/P2RX4	2
GO:0004674	protein serine/threonine kinase activity	20/859	386/18367	0.350737773771612	0.70294257268412	LTBP1/ENG/ACVRL1/PRKAG2/PHKG1/NUAK1/PTK2B/HUNK/PRKD3/PKN1/PLK2/BMPR2/MAPK6/DAPK1/PINK1/TRIO/MAPK3/CSNK1A1/HIPK3/TGFBR3	20
GO:0005200	structural constituent of cytoskeleton	6/859	103/18367	0.351069604871955	0.70294257268412	TPM1/KRT19/TUBB2A/HIP1/ACTB/TUBB6	6
GO:0048156	tau protein binding	3/859	45/18367	0.352262524449176	0.703720796559427	APOE/ACTB/PICALM	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/859	124/18367	0.360550594253821	0.713223332953776	HPGD/HSD3B1/UGDH/DHRS3/H6PD/CTBP2/RDH10	7
GO:0001671	ATPase activator activity	2/859	27/18367	0.362201836118557	0.713223332953776	TOR1AIP2/DNAJC10	2
GO:0016405	CoA-ligase activity	2/859	27/18367	0.362201836118557	0.713223332953776	ACSL4/ACSL3	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/859	47/18367	0.378077861484527	0.713223332953776	DUSP4/SSH2/PTP4A1	3
GO:0003953	NAD+ nucleosidase activity	2/859	28/18367	0.379215607294823	0.713223332953776	IL1R1/IL1RAP	2
GO:0046875	ephrin receptor binding	2/859	28/18367	0.379215607294823	0.713223332953776	EFNB1/EFNA1	2
GO:0051861	glycolipid binding	2/859	28/18367	0.379215607294823	0.713223332953776	PSAP/GPAA1	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/859	28/18367	0.379215607294823	0.713223332953776	HERPUD1/ANKRD9	2
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/859	10/18367	0.380657481702187	0.713223332953776	ENDOG	1
GO:0001094	TFIID-class transcription factor complex binding	1/859	10/18367	0.380657481702187	0.713223332953776	TP53	1
GO:0004955	prostaglandin receptor activity	1/859	10/18367	0.380657481702187	0.713223332953776	HPGD	1
GO:0005384	manganese ion transmembrane transporter activity	1/859	10/18367	0.380657481702187	0.713223332953776	SLC39A8	1
GO:0005528	FK506 binding	1/859	10/18367	0.380657481702187	0.713223332953776	FKBP10	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/859	10/18367	0.380657481702187	0.713223332953776	DUSP4	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/859	10/18367	0.380657481702187	0.713223332953776	SLC35A3	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/859	10/18367	0.380657481702187	0.713223332953776	SLC7A1	1
GO:0015232	heme transmembrane transporter activity	1/859	10/18367	0.380657481702187	0.713223332953776	PGRMC2	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/859	10/18367	0.380657481702187	0.713223332953776	PIK3CB	1
GO:0016595	glutamate binding	1/859	10/18367	0.380657481702187	0.713223332953776	SLC1A3	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1/859	10/18367	0.380657481702187	0.713223332953776	ACOX1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/859	10/18367	0.380657481702187	0.713223332953776	FADS3	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/859	10/18367	0.380657481702187	0.713223332953776	PGM3	1
GO:0030957	Tat protein binding	1/859	10/18367	0.380657481702187	0.713223332953776	ACTB	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/859	10/18367	0.380657481702187	0.713223332953776	HDAC5	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/859	10/18367	0.380657481702187	0.713223332953776	ACSL4	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/859	10/18367	0.380657481702187	0.713223332953776	HDAC5	1
GO:0043208	glycosphingolipid binding	1/859	10/18367	0.380657481702187	0.713223332953776	PSAP	1
GO:0050786	RAGE receptor binding	1/859	10/18367	0.380657481702187	0.713223332953776	S100A13	1
GO:0070016	armadillo repeat domain binding	1/859	10/18367	0.380657481702187	0.713223332953776	TCF7L2	1
GO:0003727	single-stranded RNA binding	5/859	87/18367	0.38491543970803	0.719660277231893	HNRNPH1/PABPC1/FMR1/EIF4B/RBPMS	5
GO:0140678	molecular function inhibitor activity	7/859	128/18367	0.39139175623596	0.730008546046714	APOC1/ANGPTL4/ID3/ANXA4/PRPSAP1/TMBIM6/ID1	7
GO:0004033	aldo-keto reductase (NADP) activity	2/859	29/18367	0.396035000362618	0.730008546046714	DHRS3/RDH10	2
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	2/859	29/18367	0.396035000362618	0.730008546046714	PIPOX/PYCR1	2
GO:0005525	GTP binding	19/859	377/18367	0.402068458341149	0.730008546046714	RRAD/TUBB2A/RHOU/ATL3/RAB8B/INSR/RHOD/DNM2/DAPK1/ARF4/RHOBTB3/SAR1A/ARL8B/TUBB6/GNAQ/RHEB/ARL5B/RHOC/RND3	19
GO:0004016	adenylate cyclase activity	1/859	11/18367	0.409639081267356	0.730008546046714	ADCY7	1
GO:0004143	diacylglycerol kinase activity	1/859	11/18367	0.409639081267356	0.730008546046714	DGKZ	1
GO:0004954	prostanoid receptor activity	1/859	11/18367	0.409639081267356	0.730008546046714	HPGD	1
GO:0005078	MAP-kinase scaffold activity	1/859	11/18367	0.409639081267356	0.730008546046714	IQGAP1	1
GO:0005436	sodium:phosphate symporter activity	1/859	11/18367	0.409639081267356	0.730008546046714	MFSD2A	1
GO:0005536	glucose binding	1/859	11/18367	0.409639081267356	0.730008546046714	PYGL	1
GO:0008503	benzodiazepine receptor activity	1/859	11/18367	0.409639081267356	0.730008546046714	TSPO	1
GO:0015378	sodium:chloride symporter activity	1/859	11/18367	0.409639081267356	0.730008546046714	SLC6A2	1
GO:0016273	arginine N-methyltransferase activity	1/859	11/18367	0.409639081267356	0.730008546046714	CARM1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/859	11/18367	0.409639081267356	0.730008546046714	CARM1	1
GO:0032052	bile acid binding	1/859	11/18367	0.409639081267356	0.730008546046714	PYGL	1
GO:0035251	UDP-glucosyltransferase activity	1/859	11/18367	0.409639081267356	0.730008546046714	UGCG	1
GO:0035673	oligopeptide transmembrane transporter activity	1/859	11/18367	0.409639081267356	0.730008546046714	SLC15A3	1
GO:0043295	glutathione binding	1/859	11/18367	0.409639081267356	0.730008546046714	PTGES	1
GO:0043522	leucine zipper domain binding	1/859	11/18367	0.409639081267356	0.730008546046714	ATF4	1
GO:0070513	death domain binding	1/859	11/18367	0.409639081267356	0.730008546046714	DAP	1
GO:0097371	MDM2/MDM4 family protein binding	1/859	11/18367	0.409639081267356	0.730008546046714	TP53	1
GO:1901474	azole transmembrane transporter activity	1/859	11/18367	0.409639081267356	0.730008546046714	SLC7A1	1
GO:1990226	histone methyltransferase binding	1/859	11/18367	0.409639081267356	0.730008546046714	CTNNB1	1
GO:0005343	organic acid:sodium symporter activity	2/859	30/18367	0.412640983442885	0.73237497061364	SLC23A2/SLC1A3	2
GO:0046966	thyroid hormone receptor binding	2/859	30/18367	0.412640983442885	0.73237497061364	HMGN3/TACC1	2
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	3/859	50/18367	0.416352474433359	0.737466427387023	IL1R1/IL1RAP/MAN2A1	3
GO:0005125	cytokine activity	12/859	235/18367	0.419519503927826	0.7415748806805	TNFSF10/EBI3/TIMP1/GDF15/CMTM3/TGFB1/TGFB2/INHA/BMP1/GRN/FAM3C/MIF	12
GO:0031491	nucleosome binding	4/859	71/18367	0.425996415704231	0.745824102780536	HMGN3/ACTB/MBD2/MBD3	4
GO:0051018	protein kinase A binding	3/859	51/18367	0.428946693468517	0.745824102780536	PRRC1/PRKAR2A/EZR	3
GO:0016878	acid-thiol ligase activity	2/859	31/18367	0.429016725587168	0.745824102780536	ACSL4/ACSL3	2
GO:0043015	gamma-tubulin binding	2/859	31/18367	0.429016725587168	0.745824102780536	NDRG1/ARHGEF7	2
GO:0090482	vitamin transmembrane transporter activity	2/859	31/18367	0.429016725587168	0.745824102780536	SLC23A2/LMBRD1	2
GO:0008235	metalloexopeptidase activity	4/859	72/18367	0.43654655163237	0.745824102780536	LVRN/CPM/MMP14/ERAP1	4
GO:0003995	acyl-CoA dehydrogenase activity	1/859	12/18367	0.437266016830188	0.745824102780536	TECR	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/859	12/18367	0.437266016830188	0.745824102780536	CDKN1C	1
GO:0005165	neurotrophin receptor binding	1/859	12/18367	0.437266016830188	0.745824102780536	PIK3R1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/859	12/18367	0.437266016830188	0.745824102780536	SLC35A3	1
GO:0005527	macrolide binding	1/859	12/18367	0.437266016830188	0.745824102780536	FKBP10	1
GO:0017154	semaphorin receptor activity	1/859	12/18367	0.437266016830188	0.745824102780536	PLXNB2	1
GO:0042975	peroxisome proliferator activated receptor binding	1/859	12/18367	0.437266016830188	0.745824102780536	TACC1	1
GO:0043422	protein kinase B binding	1/859	12/18367	0.437266016830188	0.745824102780536	PINK1	1
GO:0045295	gamma-catenin binding	1/859	12/18367	0.437266016830188	0.745824102780536	TCF7L2	1
GO:0061578	Lys63-specific deubiquitinase activity	1/859	12/18367	0.437266016830188	0.745824102780536	TNFAIP3	1
GO:0070410	co-SMAD binding	1/859	12/18367	0.437266016830188	0.745824102780536	SMAD3	1
GO:1900750	oligopeptide binding	1/859	12/18367	0.437266016830188	0.745824102780536	PTGES	1
GO:0003774	cytoskeletal motor activity	6/859	114/18367	0.443544713147582	0.753392657310724	KIF21A/MYO10/MYH9/MYO6/MYO9B/MYO1C	6
GO:0001223	transcription coactivator binding	2/859	32/18367	0.445147432948165	0.753392657310724	EPAS1/SMAD3	2
GO:0031624	ubiquitin conjugating enzyme binding	2/859	32/18367	0.445147432948165	0.753392657310724	ANKIB1/RNF144B	2
GO:0051721	protein phosphatase 2A binding	2/859	32/18367	0.445147432948165	0.753392657310724	EIF4EBP1/TP53	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/859	53/18367	0.453830446688514	0.761071943287902	SLC6A2/SLC16A3/SLC16A1	3
GO:0003725	double-stranded RNA binding	4/859	74/18367	0.457473517906803	0.761071943287902	MTDH/LRRFIP1/ACTN1/EIF4B	4
GO:0017022	myosin binding	4/859	74/18367	0.457473517906803	0.761071943287902	LIMCH1/STXBP5/CALD1/GSN	4
GO:0005154	epidermal growth factor receptor binding	2/859	33/18367	0.461020195431651	0.761071943287902	HIP1/ARF4	2
GO:0051427	hormone receptor binding	2/859	33/18367	0.461020195431651	0.761071943287902	CSH1/JAK1	2
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/859	13/18367	0.463601538025659	0.761071943287902	PPP1R14B	1
GO:0008195	phosphatidate phosphatase activity	1/859	13/18367	0.463601538025659	0.761071943287902	PLPP3	1
GO:0008253	5'-nucleotidase activity	1/859	13/18367	0.463601538025659	0.761071943287902	NT5DC2	1
GO:0016840	carbon-nitrogen lyase activity	1/859	13/18367	0.463601538025659	0.761071943287902	PAM	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/859	13/18367	0.463601538025659	0.761071943287902	DUSP4	1
GO:0032036	myosin heavy chain binding	1/859	13/18367	0.463601538025659	0.761071943287902	LIMCH1	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/859	13/18367	0.463601538025659	0.761071943287902	INPPL1	1
GO:0051011	microtubule minus-end binding	1/859	13/18367	0.463601538025659	0.761071943287902	MACF1	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/859	13/18367	0.463601538025659	0.761071943287902	CCNYL1	1
GO:0070700	BMP receptor binding	1/859	13/18367	0.463601538025659	0.761071943287902	GDF15	1
GO:0140299	small molecule sensor activity	1/859	13/18367	0.463601538025659	0.761071943287902	EFHD1	1
GO:0099106	ion channel regulator activity	7/859	139/18367	0.475769962586824	0.779524977211793	RRAD/PRSS8/FXYD5/FLNA/PKP2/PTPN3/SRI	7
GO:0016831	carboxy-lyase activity	2/859	34/18367	0.476623843209496	0.779524977211793	AMD1/UXS1	2
GO:0022853	active ion transmembrane transporter activity	13/859	267/18367	0.481269179460083	0.78175082550676	SLCO2A1/SLC4A7/SLC6A2/SLC12A8/SLC39A8/SLC23A2/MFSD2A/ATP6V0E1/SLC17A5/TMCO3/SLC15A3/SLC6A8/SLC1A3	13
GO:0004065	arylsulfatase activity	1/859	14/18367	0.488705944631083	0.78175082550676	ARSA	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/859	14/18367	0.488705944631083	0.78175082550676	PIK3R1	1
GO:0005313	L-glutamate transmembrane transporter activity	1/859	14/18367	0.488705944631083	0.78175082550676	SLC1A3	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/859	14/18367	0.488705944631083	0.78175082550676	LYPLA1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/859	14/18367	0.488705944631083	0.78175082550676	B3GNT7	1
GO:0015373	anion:sodium symporter activity	1/859	14/18367	0.488705944631083	0.78175082550676	SLC6A2	1
GO:0031005	filamin binding	1/859	14/18367	0.488705944631083	0.78175082550676	FBLIM1	1
GO:0032977	membrane insertase activity	1/859	14/18367	0.488705944631083	0.78175082550676	EMC10	1
GO:0043023	ribosomal large subunit binding	1/859	14/18367	0.488705944631083	0.78175082550676	LTN1	1
GO:0071837	HMG box domain binding	1/859	14/18367	0.488705944631083	0.78175082550676	GATA3	1
GO:0098599	palmitoyl hydrolase activity	1/859	14/18367	0.488705944631083	0.78175082550676	LYPLA1	1
GO:0019001	guanyl nucleotide binding	19/859	398/18367	0.496970797826323	0.790761400436091	RRAD/TUBB2A/RHOU/ATL3/RAB8B/INSR/RHOD/DNM2/DAPK1/ARF4/RHOBTB3/SAR1A/ARL8B/TUBB6/GNAQ/RHEB/ARL5B/RHOC/RND3	19
GO:0032561	guanyl ribonucleotide binding	19/859	398/18367	0.496970797826323	0.790761400436091	RRAD/TUBB2A/RHOU/ATL3/RAB8B/INSR/RHOD/DNM2/DAPK1/ARF4/RHOBTB3/SAR1A/ARL8B/TUBB6/GNAQ/RHEB/ARL5B/RHOC/RND3	19
GO:0004536	deoxyribonuclease activity	3/859	57/18367	0.502148820318656	0.790761400436091	DNASE1L3/ENDOG/PLD3	3
GO:0005484	SNAP receptor activity	2/859	36/18367	0.506987020122789	0.790761400436091	SNAP23/SEC22B	2
GO:0001846	opsonin binding	1/859	15/18367	0.51263672398933	0.790761400436091	CALR	1
GO:0004953	icosanoid receptor activity	1/859	15/18367	0.51263672398933	0.790761400436091	HPGD	1
GO:0005452	inorganic anion exchanger activity	1/859	15/18367	0.51263672398933	0.790761400436091	SLC4A7	1
GO:0008020	G protein-coupled photoreceptor activity	1/859	15/18367	0.51263672398933	0.790761400436091	OPN3	1
GO:0008252	nucleotidase activity	1/859	15/18367	0.51263672398933	0.790761400436091	NT5DC2	1
GO:0008559	ABC-type xenobiotic transporter activity	1/859	15/18367	0.51263672398933	0.790761400436091	RALBP1	1
GO:0010851	cyclase regulator activity	1/859	15/18367	0.51263672398933	0.790761400436091	GUCA2A	1
GO:0017136	NAD-dependent histone deacetylase activity	1/859	15/18367	0.51263672398933	0.790761400436091	HDAC5	1
GO:0019215	intermediate filament binding	1/859	15/18367	0.51263672398933	0.790761400436091	PKP2	1
GO:0030280	structural constituent of skin epidermis	1/859	15/18367	0.51263672398933	0.790761400436091	KRT10	1
GO:0034483	heparan sulfate sulfotransferase activity	1/859	15/18367	0.51263672398933	0.790761400436091	HS6ST1	1
GO:0042809	vitamin D receptor binding	1/859	15/18367	0.51263672398933	0.790761400436091	RXRA	1
GO:0043138	3'-5' DNA helicase activity	1/859	15/18367	0.51263672398933	0.790761400436091	NAV2	1
GO:0047372	acylglycerol lipase activity	1/859	15/18367	0.51263672398933	0.790761400436091	MGLL	1
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	1/859	15/18367	0.51263672398933	0.790761400436091	KCNJ2	1
GO:1990825	sequence-specific mRNA binding	1/859	15/18367	0.51263672398933	0.790761400436091	FMR1	1
GO:0003714	transcription corepressor activity	9/859	187/18367	0.513317114797371	0.790761400436091	NRIP1/CITED2/IRF2BPL/WWTR1/NCOR2/FHL2/TLE3/CTBP2/RBFOX2	9
GO:0016247	channel regulator activity	7/859	145/18367	0.520574744920487	0.799253786403675	RRAD/PRSS8/FXYD5/FLNA/PKP2/PTPN3/SRI	7
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/859	16/18367	0.535448682037126	0.799253786403675	CAPN2	1
GO:0005283	amino acid:sodium symporter activity	1/859	16/18367	0.535448682037126	0.799253786403675	SLC1A3	1
GO:0005523	tropomyosin binding	1/859	16/18367	0.535448682037126	0.799253786403675	CALD1	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/859	16/18367	0.535448682037126	0.799253786403675	SLCO2A1	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/859	16/18367	0.535448682037126	0.799253786403675	SLC1A5	1
GO:0016004	phospholipase activator activity	1/859	16/18367	0.535448682037126	0.799253786403675	GM2A	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/859	16/18367	0.535448682037126	0.799253786403675	PIK3CB	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/859	16/18367	0.535448682037126	0.799253786403675	DNASE1L3	1
GO:0019841	retinol binding	1/859	16/18367	0.535448682037126	0.799253786403675	CRABP2	1
GO:0022841	potassium ion leak channel activity	1/859	16/18367	0.535448682037126	0.799253786403675	KCNK12	1
GO:0034979	NAD-dependent protein deacetylase activity	1/859	16/18367	0.535448682037126	0.799253786403675	HDAC5	1
GO:0035173	histone kinase activity	1/859	16/18367	0.535448682037126	0.799253786403675	PKN1	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/859	16/18367	0.535448682037126	0.799253786403675	PIK3R1	1
GO:0070492	oligosaccharide binding	1/859	16/18367	0.535448682037126	0.799253786403675	CHID1	1
GO:1990404	protein ADP-ribosylase activity	1/859	16/18367	0.535448682037126	0.799253786403675	TNKS2	1
GO:0004520	endodeoxyribonuclease activity	2/859	38/18367	0.536177524312472	0.799253786403675	DNASE1L3/ENDOG	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/859	38/18367	0.536177524312472	0.799253786403675	ANKIB1/RNF144B	2
GO:0001786	phosphatidylserine binding	3/859	60/18367	0.536905827148523	0.799253786403675	SYT8/SCARB1/SCARB2	3
GO:0043621	protein self-association	3/859	61/18367	0.548180193300981	0.799253786403675	TNFAIP3/AGA/TP53	3
GO:0042826	histone deacetylase binding	6/859	127/18367	0.548747878400952	0.799253786403675	NRIP1/GCM1/NCOR2/PKN1/HDAC5/TP53	6
GO:0043021	ribonucleoprotein complex binding	7/859	149/18367	0.549646426296939	0.799253786403675	GCN1/RPN2/SEC61A1/LTN1/FMR1/TMCO1/EIF4B	7
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/859	39/18367	0.550320039841752	0.799253786403675	MYO10/IQGAP1	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/859	39/18367	0.550320039841752	0.799253786403675	TJP2/CMPK1	2
GO:0000400	four-way junction DNA binding	1/859	17/18367	0.557194068235705	0.799253786403675	HMGB3	1
GO:0003951	NAD+ kinase activity	1/859	17/18367	0.557194068235705	0.799253786403675	DGKZ	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/859	17/18367	0.557194068235705	0.799253786403675	PTPRF	1
GO:0005005	transmembrane-ephrin receptor activity	1/859	17/18367	0.557194068235705	0.799253786403675	EPHB2	1
GO:0009881	photoreceptor activity	1/859	17/18367	0.557194068235705	0.799253786403675	OPN3	1
GO:0015095	magnesium ion transmembrane transporter activity	1/859	17/18367	0.557194068235705	0.799253786403675	MAGT1	1
GO:0015174	basic amino acid transmembrane transporter activity	1/859	17/18367	0.557194068235705	0.799253786403675	SLC7A1	1
GO:0015278	calcium-release channel activity	1/859	17/18367	0.557194068235705	0.799253786403675	ITPR2	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/859	17/18367	0.557194068235705	0.799253786403675	PTPRF	1
GO:0030275	LRR domain binding	1/859	17/18367	0.557194068235705	0.799253786403675	ATF4	1
GO:0032393	MHC class I receptor activity	1/859	17/18367	0.557194068235705	0.799253786403675	CTSH	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	1/859	17/18367	0.557194068235705	0.799253786403675	ATP6V0E1	1
GO:0043024	ribosomal small subunit binding	1/859	17/18367	0.557194068235705	0.799253786403675	EIF4B	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1/859	17/18367	0.557194068235705	0.799253786403675	ATP6V0E1	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1/859	17/18367	0.557194068235705	0.799253786403675	ATP6V0E1	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/859	17/18367	0.557194068235705	0.799253786403675	B3GNT7	1
GO:0050780	dopamine receptor binding	1/859	17/18367	0.557194068235705	0.799253786403675	DNM2	1
GO:0052745	inositol phosphate phosphatase activity	1/859	17/18367	0.557194068235705	0.799253786403675	IMPA2	1
GO:1990841	promoter-specific chromatin binding	3/859	62/18367	0.55929167388527	0.800949614811147	SMAD3/EGR1/TP53	3
GO:0015144	carbohydrate transmembrane transporter activity	2/859	40/18367	0.564156033753382	0.803968289143664	SLC23A2/SLC17A5	2
GO:0042287	MHC protein binding	2/859	40/18367	0.564156033753382	0.803968289143664	TAP1/TAPBP	2
GO:0044183	protein folding chaperone	2/859	40/18367	0.564156033753382	0.803968289143664	HSPB1/CALR	2
GO:0090079	translation regulator activity, nucleic acid binding	5/859	108/18367	0.573320913583857	0.806510937561927	RPS27L/GCN1/PABPC1/EIF4G2/EIF4B	5
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/859	41/18367	0.577683213835798	0.806510937561927	ACSL4/ACSL3	2
GO:0048487	beta-tubulin binding	2/859	41/18367	0.577683213835798	0.806510937561927	SLC6A2/ARL8B	2
GO:0004550	nucleoside diphosphate kinase activity	1/859	18/18367	0.577922694687232	0.806510937561927	CMPK1	1
GO:0004708	MAP kinase kinase activity	1/859	18/18367	0.577922694687232	0.806510937561927	MAPK3	1
GO:0008301	DNA binding, bending	1/859	18/18367	0.577922694687232	0.806510937561927	HMGB3	1
GO:0008409	5'-3' exonuclease activity	1/859	18/18367	0.577922694687232	0.806510937561927	PLD3	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/859	18/18367	0.577922694687232	0.806510937561927	SASH1	1
GO:0033549	MAP kinase phosphatase activity	1/859	18/18367	0.577922694687232	0.806510937561927	DUSP4	1
GO:0046624	sphingolipid transporter activity	1/859	18/18367	0.577922694687232	0.806510937561927	ABCA1	1
GO:0050811	GABA receptor binding	1/859	18/18367	0.577922694687232	0.806510937561927	PLCL2	1
GO:0060229	lipase activator activity	1/859	18/18367	0.577922694687232	0.806510937561927	GM2A	1
GO:0140597	protein carrier activity	1/859	18/18367	0.577922694687232	0.806510937561927	EMC10	1
GO:0001046	core promoter sequence-specific DNA binding	2/859	42/18367	0.590900171523304	0.819705005476346	KLF10/TP53	2
GO:0019205	nucleobase-containing compound kinase activity	2/859	42/18367	0.590900171523304	0.819705005476346	TJP2/CMPK1	2
GO:0048306	calcium-dependent protein binding	4/859	88/18367	0.594363490487128	0.819705005476346	WFS1/ANXA4/SEC31A/S100A13	4
GO:0004970	ionotropic glutamate receptor activity	1/859	19/18367	0.597682049707324	0.819705005476346	PTK2B	1
GO:0005003	ephrin receptor activity	1/859	19/18367	0.597682049707324	0.819705005476346	EPHB2	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/859	19/18367	0.597682049707324	0.819705005476346	SLC6A2	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/859	19/18367	0.597682049707324	0.819705005476346	PYCR1	1
GO:0022840	leak channel activity	1/859	19/18367	0.597682049707324	0.819705005476346	KCNK12	1
GO:0022842	narrow pore channel activity	1/859	19/18367	0.597682049707324	0.819705005476346	KCNK12	1
GO:0035613	RNA stem-loop binding	1/859	19/18367	0.597682049707324	0.819705005476346	FMR1	1
GO:0052742	phosphatidylinositol kinase activity	1/859	19/18367	0.597682049707324	0.819705005476346	PIK3CB	1
GO:0005246	calcium channel regulator activity	2/859	43/18367	0.603806304434074	0.826808319843215	RRAD/SRI	2
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/859	20/18367	0.616517406111369	0.831206056005312	TP53	1
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	1/859	20/18367	0.616517406111369	0.831206056005312	ATP6V0E1	1
GO:0016500	protein-hormone receptor activity	1/859	20/18367	0.616517406111369	0.831206056005312	INSR	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/859	20/18367	0.616517406111369	0.831206056005312	SGMS2	1
GO:0030296	protein tyrosine kinase activator activity	1/859	20/18367	0.616517406111369	0.831206056005312	ERBB3	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/859	20/18367	0.616517406111369	0.831206056005312	GNAQ	1
GO:0031690	adrenergic receptor binding	1/859	20/18367	0.616517406111369	0.831206056005312	SH3GL1	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/859	20/18367	0.616517406111369	0.831206056005312	PIK3R1	1
GO:0070300	phosphatidic acid binding	1/859	20/18367	0.616517406111369	0.831206056005312	SESTD1	1
GO:0097001	ceramide binding	1/859	20/18367	0.616517406111369	0.831206056005312	PSAP	1
GO:0016407	acetyltransferase activity	4/859	91/18367	0.620922502850157	0.835857215375212	LPCAT1/SAT1/NCOA1/PAFAH1B2	4
GO:0001614	purinergic nucleotide receptor activity	1/859	21/18367	0.634471924460436	0.841155960458911	P2RX4	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/859	21/18367	0.634471924460436	0.841155960458911	LPCAT1	1
GO:0004407	histone deacetylase activity	1/859	21/18367	0.634471924460436	0.841155960458911	HDAC5	1
GO:0005243	gap junction channel activity	1/859	21/18367	0.634471924460436	0.841155960458911	GJA5	1
GO:0008373	sialyltransferase activity	1/859	21/18367	0.634471924460436	0.841155960458911	ST3GAL6	1
GO:0016502	nucleotide receptor activity	1/859	21/18367	0.634471924460436	0.841155960458911	P2RX4	1
GO:0051010	microtubule plus-end binding	1/859	21/18367	0.634471924460436	0.841155960458911	MAPRE2	1
GO:0070577	lysine-acetylated histone binding	1/859	21/18367	0.634471924460436	0.841155960458911	CARM1	1
GO:0140033	acetylation-dependent protein binding	1/859	21/18367	0.634471924460436	0.841155960458911	CARM1	1
GO:1990381	ubiquitin-specific protease binding	1/859	21/18367	0.634471924460436	0.841155960458911	AMFR	1
GO:0072341	modified amino acid binding	4/859	93/18367	0.638007804844821	0.844564038183387	PTGES/SYT8/SCARB1/SCARB2	4
GO:0140296	general transcription initiation factor binding	2/859	46/18367	0.640664342527535	0.846799546392135	TAF13/TP53	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/859	71/18367	0.651493246243057	0.849394339578273	HDAC5/AGA/GLS	3
GO:0005416	amino acid:cation symporter activity	1/859	22/18367	0.651586751501125	0.849394339578273	SLC1A3	1
GO:0005540	hyaluronic acid binding	1/859	22/18367	0.651586751501125	0.849394339578273	LAYN	1
GO:0009975	cyclase activity	1/859	22/18367	0.651586751501125	0.849394339578273	ADCY7	1
GO:0030742	GTP-dependent protein binding	1/859	22/18367	0.651586751501125	0.849394339578273	AP1G1	1
GO:0033558	protein deacetylase activity	1/859	22/18367	0.651586751501125	0.849394339578273	HDAC5	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/859	22/18367	0.651586751501125	0.849394339578273	XIAP	1
GO:0050321	tau-protein kinase activity	1/859	22/18367	0.651586751501125	0.849394339578273	PHKG1	1
GO:0072349	modified amino acid transmembrane transporter activity	1/859	22/18367	0.651586751501125	0.849394339578273	SLC6A8	1
GO:0035254	glutamate receptor binding	2/859	47/18367	0.652334852796114	0.849394339578273	HIP1/CANX	2
GO:0070888	E-box binding	2/859	48/18367	0.663701261186265	0.855656624846222	ASCL2/GATA3	2
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/859	23/18367	0.667901114022822	0.855656624846222	TNKS2	1
GO:0004529	exodeoxyribonuclease activity	1/859	23/18367	0.667901114022822	0.855656624846222	PLD3	1
GO:0015299	solute:proton antiporter activity	1/859	23/18367	0.667901114022822	0.855656624846222	TMCO3	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/859	23/18367	0.667901114022822	0.855656624846222	PLD3	1
GO:0017025	TBP-class protein binding	1/859	23/18367	0.667901114022822	0.855656624846222	TAF13	1
GO:0019865	immunoglobulin binding	1/859	23/18367	0.667901114022822	0.855656624846222	LGALS3	1
GO:0030552	cAMP binding	1/859	23/18367	0.667901114022822	0.855656624846222	PRKAR2A	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/859	23/18367	0.667901114022822	0.855656624846222	LPCAT1	1
GO:0070412	R-SMAD binding	1/859	23/18367	0.667901114022822	0.855656624846222	SMAD3	1
GO:0071617	lysophospholipid acyltransferase activity	1/859	23/18367	0.667901114022822	0.855656624846222	LPCAT1	1
GO:0070063	RNA polymerase binding	3/859	73/18367	0.670001519853431	0.857092587531802	ERBB2/SMYD3/PPIB	3
GO:0008171	O-methyltransferase activity	1/859	24/18367	0.683452408345456	0.869216362357957	COMTD1	1
GO:0015145	monosaccharide transmembrane transporter activity	1/859	24/18367	0.683452408345456	0.869216362357957	SLC23A2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/859	24/18367	0.683452408345456	0.869216362357957	GDF15	1
GO:0070840	dynein complex binding	1/859	24/18367	0.683452408345456	0.869216362357957	FMR1	1
GO:0019003	GDP binding	3/859	75/18367	0.687779194701853	0.873449630426881	RAB8B/ARL8B/RHEB	3
GO:0003743	translation initiation factor activity	2/859	51/18367	0.696006638746236	0.881661976819382	EIF4G2/EIF4B	2
GO:0005104	fibroblast growth factor receptor binding	1/859	25/18367	0.698276285640951	0.881661976819382	NPTN	1
GO:0005242	inward rectifier potassium channel activity	1/859	25/18367	0.698276285640951	0.881661976819382	KCNJ2	1
GO:0051019	mitogen-activated protein kinase binding	1/859	25/18367	0.698276285640951	0.881661976819382	IQGAP1	1
GO:0008146	sulfotransferase activity	2/859	52/18367	0.706189210453167	0.886535952864449	DSEL/HS6ST1	2
GO:0016830	carbon-carbon lyase activity	2/859	52/18367	0.706189210453167	0.886535952864449	AMD1/UXS1	2
GO:0031593	polyubiquitin modification-dependent protein binding	2/859	52/18367	0.706189210453167	0.886535952864449	TNFAIP3/FAAP20	2
GO:1901682	sulfur compound transmembrane transporter activity	2/859	52/18367	0.706189210453167	0.886535952864449	RALBP1/MFSD12	2
GO:0004364	glutathione transferase activity	1/859	26/18367	0.712406733282125	0.886708238437922	PTGES	1
GO:0008198	ferrous iron binding	1/859	26/18367	0.712406733282125	0.886708238437922	EGLN3	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/859	26/18367	0.712406733282125	0.886708238437922	ZDHHC9	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/859	26/18367	0.712406733282125	0.886708238437922	ZDHHC9	1
GO:0038187	pattern recognition receptor activity	1/859	26/18367	0.712406733282125	0.886708238437922	SCARB1	1
GO:0097602	cullin family protein binding	1/859	26/18367	0.712406733282125	0.886708238437922	DDB1	1
GO:0046873	metal ion transmembrane transporter activity	18/859	430/18367	0.719637542358106	0.893307501200177	SLC4A7/SLC6A2/SLC39A6/SLC12A8/KCNK12/SLC30A2/SLC39A8/SLC23A2/MFSD2A/KCNJ2/SEC61A1/SLC6A8/ITPR2/P2RX4/SLC1A3/MAGT1/TMCO1/SLC39A7	18
GO:0015081	sodium ion transmembrane transporter activity	6/859	152/18367	0.720305190024265	0.893307501200177	SLC4A7/SLC6A2/SLC23A2/MFSD2A/SLC6A8/SLC1A3	6
GO:0005544	calcium-dependent phospholipid binding	2/859	54/18367	0.72570036357818	0.893307501200177	SYT8/ANXA4	2
GO:0008066	glutamate receptor activity	1/859	27/18367	0.725876152403801	0.893307501200177	PTK2B	1
GO:0016866	intramolecular transferase activity	1/859	27/18367	0.725876152403801	0.893307501200177	PGM3	1
GO:0030507	spectrin binding	1/859	27/18367	0.725876152403801	0.893307501200177	MYO10	1
GO:0035255	ionotropic glutamate receptor binding	1/859	27/18367	0.725876152403801	0.893307501200177	CANX	1
GO:0051119	sugar transmembrane transporter activity	1/859	27/18367	0.725876152403801	0.893307501200177	SLC23A2	1
GO:0004842	ubiquitin-protein transferase activity	18/859	433/18367	0.730204159919666	0.897371685294534	IRF2BPL/HERC1/TTC3/TNFAIP3/CBLB/UBE2Q2/ANKIB1/LTN1/DTX4/RNF144B/RNF139/SEL1L/RNF13/XIAP/AMFR/UBE2K/HERC4/UBE2A	18
GO:0015078	proton transmembrane transporter activity	5/859	130/18367	0.732940724377658	0.899471435947336	SLC39A8/ATP6V0E1/SLC17A5/TMCO3/SLC15A3	5
GO:0035591	signaling adaptor activity	3/859	81/18367	0.736775045108719	0.902910594495979	IQGAP1/CDC42SE2/PIK3R1	3
GO:0015101	organic cation transmembrane transporter activity	1/859	28/18367	0.738715431852282	0.904022381637407	SLC44A2	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/859	56/18367	0.744103602578498	0.908076223509324	CST6/XIAP	2
GO:0042054	histone methyltransferase activity	2/859	56/18367	0.744103602578498	0.908076223509324	SMYD3/CARM1	2
GO:0015399	primary active transmembrane transporter activity	7/859	181/18367	0.747748987902759	0.908830935483815	ABCA7/RALBP1/TAP1/TAPBP/ABCA1/ATP6V0E1/LMBRD1	7
GO:0004181	metallocarboxypeptidase activity	1/859	29/18367	0.750954018691198	0.908830935483815	CPM	1
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/859	29/18367	0.750954018691198	0.908830935483815	P2RX4	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/859	29/18367	0.750954018691198	0.908830935483815	TECR	1
GO:0033612	receptor serine/threonine kinase binding	1/859	29/18367	0.750954018691198	0.908830935483815	GDF15	1
GO:0046625	sphingolipid binding	1/859	29/18367	0.750954018691198	0.908830935483815	PSAP	1
GO:0043175	RNA polymerase core enzyme binding	2/859	57/18367	0.752901958297037	0.909929852914237	ERBB2/SMYD3	2
GO:0008135	translation factor activity, RNA binding	3/859	84/18367	0.758891660763779	0.912848819761848	GCN1/EIF4G2/EIF4B	3
GO:0005217	intracellular ligand-gated ion channel activity	1/859	30/18367	0.762619985423898	0.912848819761848	ITPR2	1
GO:0005310	dicarboxylic acid transmembrane transporter activity	1/859	30/18367	0.762619985423898	0.912848819761848	SLC1A5	1
GO:0016417	S-acyltransferase activity	1/859	30/18367	0.762619985423898	0.912848819761848	ZDHHC9	1
GO:0017147	Wnt-protein binding	1/859	30/18367	0.762619985423898	0.912848819761848	SFRP1	1
GO:0022829	wide pore channel activity	1/859	30/18367	0.762619985423898	0.912848819761848	GJA5	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/859	30/18367	0.762619985423898	0.912848819761848	HSD3B1	1
GO:0140030	modification-dependent protein binding	6/859	160/18367	0.764414665183523	0.913747038299977	ANKRD13A/TNFAIP3/CARM1/SPIN1/FMR1/FAAP20	6
GO:0005164	tumor necrosis factor receptor binding	1/859	31/18367	0.773740094085123	0.921119159625146	TNFSF10	1
GO:0016411	acylglycerol O-acyltransferase activity	1/859	31/18367	0.773740094085123	0.921119159625146	LPCAT1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/859	31/18367	0.773740094085123	0.921119159625146	RALBP1	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/859	60/18367	0.77774575848229	0.924629807978266	TECR/ACOX1	2
GO:0099094	ligand-gated cation channel activity	4/859	113/18367	0.78037538492853	0.924929077060855	PTK2B/KCNJ2/ITPR2/P2RX4	4
GO:0001222	transcription corepressor binding	1/859	32/18367	0.784339857347605	0.924929077060855	CTBP2	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/859	32/18367	0.784339857347605	0.924929077060855	MFSD2A	1
GO:0030332	cyclin binding	1/859	32/18367	0.784339857347605	0.924929077060855	CRABP2	1
GO:0048019	receptor antagonist activity	1/859	32/18367	0.784339857347605	0.924929077060855	IL18BP	1
GO:0071889	14-3-3 protein binding	1/859	32/18367	0.784339857347605	0.924929077060855	ZFP36L1	1
GO:0001530	lipopolysaccharide binding	1/859	33/18367	0.794443596782479	0.934325466646061	SCARB1	1
GO:0004623	phospholipase A2 activity	1/859	33/18367	0.794443596782479	0.934325466646061	PLA2G7	1
GO:0016229	steroid dehydrogenase activity	1/859	34/18367	0.804074498405903	0.943116871454645	HSD3B1	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/859	34/18367	0.804074498405903	0.943116871454645	INPPL1	1
GO:0019787	ubiquitin-like protein transferase activity	18/859	458/18367	0.808363504533102	0.946878268362067	IRF2BPL/HERC1/TTC3/TNFAIP3/CBLB/UBE2Q2/ANKIB1/LTN1/DTX4/RNF144B/RNF139/SEL1L/RNF13/XIAP/AMFR/UBE2K/HERC4/UBE2A	18
GO:0005262	calcium channel activity	4/859	119/18367	0.813233176606173	0.950063861726845	SEC61A1/ITPR2/P2RX4/TMCO1	4
GO:0015298	solute:cation antiporter activity	1/859	35/18367	0.813254665638179	0.950063861726845	TMCO3	1
GO:0002039	p53 binding	2/859	66/18367	0.820936164962932	0.956455483472462	NUAK1/TP53	2
GO:0016410	N-acyltransferase activity	3/859	94/18367	0.82191627677402	0.956455483472462	SAT1/NCOA1/CERS6	3
GO:0000217	DNA secondary structure binding	1/859	36/18367	0.822005169795762	0.956455483472462	HMGB3	1
GO:0005109	frizzled binding	1/859	37/18367	0.830346098230951	0.960964269801072	SFRP1	1
GO:0016409	palmitoyltransferase activity	1/859	37/18367	0.830346098230951	0.960964269801072	ZDHHC9	1
GO:0030551	cyclic nucleotide binding	1/859	37/18367	0.830346098230951	0.960964269801072	PRKAR2A	1
GO:0071855	neuropeptide receptor binding	1/859	37/18367	0.830346098230951	0.960964269801072	POMC	1
GO:0046906	tetrapyrrole binding	5/859	149/18367	0.831751272395854	0.960964269801072	CYP11A1/CD320/PGRMC1/LMBRD1/PGRMC2	5
GO:0008080	N-acetyltransferase activity	2/859	68/18367	0.833567863747444	0.960964269801072	SAT1/NCOA1	2
GO:0016782	transferase activity, transferring sulphur-containing groups	2/859	68/18367	0.833567863747444	0.960964269801072	DSEL/HS6ST1	2
GO:0003730	mRNA 3'-UTR binding	7/859	201/18367	0.835187108812721	0.96134931218893	MEX3D/IGF2BP2/PABPC1/ZFP36L1/TP53/FMR1/IGF2BP3	7
GO:0008395	steroid hydroxylase activity	1/859	38/18367	0.838296600228747	0.96134931218893	CYP11A1	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/859	38/18367	0.838296600228747	0.96134931218893	TAF13	1
GO:0019213	deacetylase activity	1/859	38/18367	0.838296600228747	0.96134931218893	HDAC5	1
GO:0004521	endoribonuclease activity	2/859	69/18367	0.839577198994614	0.961557655916606	ENDOG/RNASET2	2
GO:0015103	inorganic anion transmembrane transporter activity	5/859	152/18367	0.844244928651372	0.963423783125731	SLC4A7/SLC6A2/SLC12A8/SLC39A8/CLIC4	5
GO:0001098	basal transcription machinery binding	2/859	70/18367	0.845389316284165	0.963423783125731	SMYD3/TP53	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/859	70/18367	0.845389316284165	0.963423783125731	SMYD3/TP53	2
GO:0004402	histone acetyltransferase activity	1/859	39/18367	0.845874930765247	0.963423783125731	NCOA1	1
GO:0061630	ubiquitin protein ligase activity	11/859	304/18367	0.8467118733985	0.963423783125731	IRF2BPL/CBLB/ANKIB1/LTN1/DTX4/RNF144B/RNF139/RNF13/XIAP/AMFR/UBE2K	11
GO:0003925	G protein activity	1/859	40/18367	0.85309849222709	0.969129770307763	ARL8B	1
GO:0004812	aminoacyl-tRNA ligase activity	1/859	41/18367	0.859983874186872	0.969129770307763	RARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/859	41/18367	0.859983874186872	0.969129770307763	RARS2	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	1/859	41/18367	0.859983874186872	0.969129770307763	NCOA1	1
GO:0004497	monooxygenase activity	3/859	102/18367	0.861689848226625	0.969129770307763	PAM/CYP11A1/MICAL3	3
GO:0005230	extracellular ligand-gated ion channel activity	2/859	73/18367	0.861694812913646	0.969129770307763	PTK2B/P2RX4	2
GO:0035064	methylated histone binding	2/859	73/18367	0.861694812913646	0.969129770307763	SPIN1/FMR1	2
GO:0140034	methylation-dependent protein binding	2/859	73/18367	0.861694812913646	0.969129770307763	SPIN1/FMR1	2
GO:0140104	molecular carrier activity	2/859	73/18367	0.861694812913646	0.969129770307763	ATOX1/EMC10	2
GO:0106310	protein serine kinase activity	13/859	360/18367	0.865115380052996	0.971727801728333	PHKG1/NUAK1/HUNK/PRKD3/PKN1/PLK2/MAPK6/DAPK1/PINK1/TRIO/MAPK3/CSNK1A1/HIPK3	13
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/859	43/18367	0.872802619584316	0.974110066500352	MICAL3	1
GO:0016790	thiolester hydrolase activity	1/859	43/18367	0.872802619584316	0.974110066500352	LYPLA1	1
GO:0018024	histone-lysine N-methyltransferase activity	1/859	43/18367	0.872802619584316	0.974110066500352	SMYD3	1
GO:0030544	Hsp70 protein binding	1/859	43/18367	0.872802619584316	0.974110066500352	DNAJC10	1
GO:0030547	signaling receptor inhibitor activity	1/859	43/18367	0.872802619584316	0.974110066500352	IL18BP	1
GO:0061659	ubiquitin-like protein ligase activity	11/859	316/18367	0.878440032036947	0.97826940433798	IRF2BPL/CBLB/ANKIB1/LTN1/DTX4/RNF144B/RNF139/RNF13/XIAP/AMFR/UBE2K	11
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/859	44/18367	0.878765430639602	0.97826940433798	MAPK3	1
GO:0003724	RNA helicase activity	2/859	77/18367	0.880986838891649	0.978868479693551	DDX60L/DDX17	2
GO:0015085	calcium ion transmembrane transporter activity	4/859	135/18367	0.881540985141164	0.978868479693551	SEC61A1/ITPR2/P2RX4/TMCO1	4
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/859	45/18367	0.884449024760684	0.979611261602024	DNASE1L3	1
GO:0140223	general transcription initiation factor activity	1/859	45/18367	0.884449024760684	0.979611261602024	TAF13	1
GO:0008186	ATP-dependent activity, acting on RNA	2/859	79/18367	0.889671511986942	0.984149902640423	DDX60L/DDX17	2
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/859	47/18367	0.895030192781633	0.988827548843344	ATP6V0E1	1
GO:0048020	CCR chemokine receptor binding	1/859	48/18367	0.899952084943236	0.993011443033205	JAK1	1
GO:0016763	pentosyltransferase activity	1/859	49/18367	0.904643452323211	0.993103239621117	TNKS2	1
GO:0032813	tumor necrosis factor receptor superfamily binding	1/859	49/18367	0.904643452323211	0.993103239621117	TNFSF10	1
GO:0034212	peptide N-acetyltransferase activity	1/859	49/18367	0.904643452323211	0.993103239621117	NCOA1	1
GO:0015276	ligand-gated ion channel activity	4/859	143/18367	0.906715309530237	0.993103239621117	PTK2B/KCNJ2/ITPR2/P2RX4	4
GO:0022834	ligand-gated channel activity	4/859	143/18367	0.906715309530237	0.993103239621117	PTK2B/KCNJ2/ITPR2/P2RX4	4
GO:0000993	RNA polymerase II complex binding	1/859	50/18367	0.909115079927446	0.993103239621117	SMYD3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/859	50/18367	0.909115079927446	0.993103239621117	SLC35A3	1
GO:0030159	signaling receptor complex adaptor activity	1/859	50/18367	0.909115079927446	0.993103239621117	PIK3R1	1
GO:0004879	nuclear receptor activity	1/859	52/18367	0.917439759305931	0.998457449493395	RXRA	1
GO:0016597	amino acid binding	1/859	52/18367	0.917439759305931	0.998457449493395	SLC1A3	1
GO:0098531	ligand-activated transcription factor activity	1/859	52/18367	0.917439759305931	0.998457449493395	RXRA	1
GO:0050661	NADP binding	1/859	53/18367	0.921311954051014	0.99923135361704	H6PD	1
GO:0008276	protein methyltransferase activity	2/859	88/18367	0.921933163278511	0.99923135361704	SMYD3/CARM1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/859	88/18367	0.921933163278511	0.99923135361704	CYB5R3/CYB5R1	2
GO:0015297	antiporter activity	2/859	89/18367	0.924911224495744	0.99923135361704	SLC35E1/TMCO3	2
GO:0008374	O-acyltransferase activity	1/859	54/18367	0.925002738776917	0.99923135361704	LPCAT1	1
GO:0015459	potassium channel regulator activity	1/859	54/18367	0.925002738776917	0.99923135361704	FLNA	1
GO:0030170	pyridoxal phosphate binding	1/859	55/18367	0.928520602993082	0.999945532984829	PYGL	1
GO:0070279	vitamin B6 binding	1/859	56/18367	0.931873639364256	0.999945532984829	PYGL	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/859	125/18367	0.935878275886523	0.999945532984829	HDAC5/AGA/GLS	3
GO:0001664	G protein-coupled receptor binding	9/859	295/18367	0.937493881111934	0.999945532984829	SFRP1/ADM/POMC/FLNA/EDNRB/DNM2/JAK1/SH3GL1/GNAQ	9
GO:0008242	omega peptidase activity	3/859	126/18367	0.938061620753869	0.999945532984829	PGPEP1/TNFAIP3/OTUD1	3
GO:0009055	electron transfer activity	3/859	126/18367	0.938061620753869	0.999945532984829	P4HA2/DHRS3/UQCR11	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/859	58/18367	0.938115725322676	0.999945532984829	PTGES	1
GO:0016279	protein-lysine N-methyltransferase activity	1/859	59/18367	0.941019138504599	0.999945532984829	SMYD3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/859	59/18367	0.941019138504599	0.999945532984829	PLD3	1
GO:0036002	pre-mRNA binding	1/859	59/18367	0.941019138504599	0.999945532984829	SRSF6	1
GO:0016278	lysine N-methyltransferase activity	1/859	60/18367	0.943786483928706	0.999945532984829	SMYD3	1
GO:0022824	transmitter-gated ion channel activity	1/859	60/18367	0.943786483928706	0.999945532984829	PTK2B	1
GO:0022835	transmitter-gated channel activity	1/859	60/18367	0.943786483928706	0.999945532984829	PTK2B	1
GO:0004519	endonuclease activity	3/859	129/18367	0.944205875644692	0.999945532984829	DNASE1L3/ENDOG/RNASET2	3
GO:0008170	N-methyltransferase activity	2/859	97/18367	0.945153740692155	0.999945532984829	SMYD3/CARM1	2
GO:0000287	magnesium ion binding	6/859	221/18367	0.949564492468099	0.999945532984829	ATP11A/PINK1/PGM3/PRPSAP1/RHEB/WEE1	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	6/859	222/18367	0.950964041875897	0.999945532984829	LPCAT1/ZDHHC9/SAT1/NCOA1/PAFAH1B2/CERS6	6
GO:0016829	lyase activity	5/859	196/18367	0.954921803712065	0.999945532984829	PAM/ADCY7/AMD1/RNASET2/UXS1	5
GO:0001217	DNA-binding transcription repressor activity	9/859	313/18367	0.959698510782266	0.999945532984829	ASCL2/GATA3/SMAD3/ATF3/GLIS3/MAFK/TFAP2C/LRRFIP1/ETS2	9
GO:0020037	heme binding	3/859	139/18367	0.960831116943293	0.999945532984829	CYP11A1/PGRMC1/PGRMC2	3
GO:0003823	antigen binding	4/859	171/18367	0.961517104165937	0.999945532984829	HLA-G/TGFB1/TAP1/TAPBP	4
GO:0003684	damaged DNA binding	1/859	68/18367	0.961731996250895	0.999945532984829	DDB1	1
GO:0003777	microtubule motor activity	1/859	69/18367	0.963528390328194	0.999945532984829	KIF21A	1
GO:0000049	tRNA binding	1/859	72/18367	0.96842776789308	0.999945532984829	XPOT	1
GO:0003678	DNA helicase activity	1/859	72/18367	0.96842776789308	0.999945532984829	NAV2	1
GO:0042379	chemokine receptor binding	1/859	72/18367	0.96842776789308	0.999945532984829	JAK1	1
GO:0030594	neurotransmitter receptor activity	2/859	111/18367	0.968702724958779	0.999945532984829	TSPO/PTK2B	2
GO:0008528	G protein-coupled peptide receptor activity	3/859	147/18367	0.970652912030538	0.999945532984829	CCR1/EDNRB/ACKR2	3
GO:0004843	thiol-dependent deubiquitinase	2/859	113/18367	0.971142886905463	0.999945532984829	TNFAIP3/OTUD1	2
GO:0005254	chloride channel activity	1/859	74/18367	0.971323046613346	0.999945532984829	CLIC4	1
GO:0101005	deubiquitinase activity	2/859	114/18367	0.972293127276039	0.999945532984829	TNFAIP3/OTUD1	2
GO:0042393	histone binding	6/859	244/18367	0.974097884190508	0.999945532984829	CTSL/PKN1/CARM1/SPIN1/FMR1/IPO7	6
GO:0004540	ribonuclease activity	2/859	116/18367	0.974462317928614	0.999945532984829	ENDOG/RNASET2	2
GO:0001653	peptide receptor activity	3/859	153/18367	0.976437383936084	0.999945532984829	CCR1/EDNRB/ACKR2	3
GO:0034987	immunoglobulin receptor binding	1/859	79/18367	0.977453359134403	0.999945532984829	FLNA	1
GO:0015079	potassium ion transmembrane transporter activity	3/859	155/18367	0.978111915854977	0.999945532984829	SLC12A8/KCNK12/KCNJ2	3
GO:0016746	acyltransferase activity	6/859	250/18367	0.978365025124235	0.999945532984829	LPCAT1/ZDHHC9/SAT1/NCOA1/PAFAH1B2/CERS6	6
GO:0004527	exonuclease activity	1/859	80/18367	0.978512390439278	0.999945532984829	PLD3	1
GO:0004386	helicase activity	3/859	156/18367	0.978906086994912	0.999945532984829	DDX60L/NAV2/DDX17	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	3/859	156/18367	0.978906086994912	0.999945532984829	SMYD3/CARM1/COMTD1	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	8/859	310/18367	0.979172703393366	0.999945532984829	ASCL2/GATA3/ATF3/GLIS3/MAFK/TFAP2C/LRRFIP1/ETS2	8
GO:0005267	potassium channel activity	2/859	121/18367	0.979191385097826	0.999945532984829	KCNK12/KCNJ2	2
GO:0003697	single-stranded DNA binding	2/859	123/18367	0.9808351522855	0.999945532984829	TP53/PCBP2	2
GO:0019783	ubiquitin-like protein-specific protease activity	2/859	125/18367	0.982352694871507	0.999945532984829	TNFAIP3/OTUD1	2
GO:0005253	anion channel activity	1/859	87/18367	0.984657394393592	0.999945532984829	CLIC4	1
GO:0016874	ligase activity	3/859	165/18367	0.984917551453061	0.999945532984829	ACSL4/RARS2/ACSL3	3
GO:0031072	heat shock protein binding	2/859	129/18367	0.98504570161834	0.999945532984829	DNAJC10/LMAN2	2
GO:0005244	voltage-gated ion channel activity	4/859	201/18367	0.986090198082702	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4	4
GO:0022832	voltage-gated channel activity	4/859	201/18367	0.986090198082702	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4	4
GO:0005249	voltage-gated potassium channel activity	1/859	90/18367	0.986720360830814	0.999945532984829	KCNJ2	1
GO:0016887	ATP hydrolysis activity	6/859	272/18367	0.989035533719173	0.999945532984829	KIF21A/DDX60L/ATP11A/NAV2/RHOBTB3/DDX17	6
GO:0004518	nuclease activity	4/859	210/18367	0.98986551845204	0.999945532984829	DNASE1L3/ENDOG/PLD3/RNASET2	4
GO:0022843	voltage-gated cation channel activity	2/859	143/18367	0.991671349588474	0.999945532984829	PTK2B/KCNJ2	2
GO:0003735	structural constituent of ribosome	3/859	182/18367	0.99209758820316	0.999945532984829	RPS27L/ISG15/RPL39	3
GO:0140097	catalytic activity, acting on DNA	4/859	229/18367	0.994882085257298	0.999945532984829	DNASE1L3/ENDOG/NAV2/PLD3	4
GO:0008094	ATP-dependent activity, acting on DNA	1/859	111/18367	0.995170514593141	0.999945532984829	NAV2	1
GO:0005261	cation channel activity	7/859	335/18367	0.995977017323687	0.999945532984829	KCNK12/PTK2B/KCNJ2/SEC61A1/ITPR2/P2RX4/TMCO1	7
GO:0140101	catalytic activity, acting on a tRNA	1/859	124/18367	0.997419506508876	0.999945532984829	RARS2	1
GO:0008168	methyltransferase activity	3/859	214/18367	0.997746259427346	0.999945532984829	SMYD3/CARM1/COMTD1	3
GO:0016741	transferase activity, transferring one-carbon groups	3/859	225/18367	0.998549819904709	0.999945532984829	SMYD3/CARM1/COMTD1	3
GO:0022836	gated channel activity	6/859	340/18367	0.998859099667005	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4/ITPR2/P2RX4	6
GO:0005216	ion channel activity	8/859	432/18367	0.999511078510026	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4/SEC61A1/ITPR2/P2RX4/TMCO1	8
GO:0015267	channel activity	9/859	480/18367	0.999702852222285	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4/GJA5/SEC61A1/ITPR2/P2RX4/TMCO1	9
GO:0022803	passive transmembrane transporter activity	9/859	481/18367	0.999712473895938	0.999945532984829	KCNK12/PTK2B/KCNJ2/CLIC4/GJA5/SEC61A1/ITPR2/P2RX4/TMCO1	9
GO:0140098	catalytic activity, acting on RNA	5/859	386/18367	0.999945532984829	0.999945532984829	DDX60L/ENDOG/RARS2/RNASET2/DDX17	5