ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0009100 glycoprotein metabolic process 59/852 387/18722 2.30830205696547e-16 6.01438374935658e-13 ITM2B/BGN/TCF7L2/MGAT5/CHPF/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/ABCA7/GALNT3/UGDH/SLC39A8/GALNT2/DSEL/TMEM59/CTSL/HS6ST1/PCSK6/MGAT4A/B4GALT1/TET3/MAN2A1/MGAT1/KRTCAP2/MGAT2/RPN2/BMPR2/GFPT1/CTNNB1/PRKCSH/CHPF2/AGA/RPN1/PGM3/STT3A/ST3GAL6/B4GALT4/MAN1B1/GPC1/MGAT4B/RNF139/B4GALT5/MAN1A2/GALNT1/MOGS/ITM2C/STT3B/DSE/AMFR/TMEM258/EDEM3/NCSTN/DDOST/GOLPH3/EXT2/MAGT1/GANAB 59 GO:0042060 wound healing 62/852 422/18722 2.38997963415719e-16 6.01438374935658e-13 FN1/SERPINE2/TPM1/SERPINE1/SPARC/IL6ST/MCAM/ITGA5/SERPING1/TFPI/NOG/ITGB1/FKBP10/FBLN1/TIMP1/PRCP/CD9/F11R/CLDN19/SDC4/ACVRL1/ERBB2/GATA2/SMAD3/TGFB1/TGFB2/PROCR/APOE/EPHB2/SCARB1/FLNA/CD151/XBP1/B4GALT1/NOTCH2/PHLDB2/ACTB/CNN2/CD59/PLPP3/HSPB1/TNFAIP3/SDC1/LMAN1/MYH9/UBASH3B/DAG1/DGKZ/PTK2/ERBB3/PIK3CB/VKORC1/PPP3CA/SRSF6/ARL8B/GNAQ/VCL/CSRP1/RREB1/ADAM17/RHOC/MACF1 62 GO:0048193 Golgi vesicle transport 49/852 296/18722 3.20674729139729e-15 5.37985303920085e-12 KDELR3/SEC24D/ERGIC1/SEC23A/PLPP3/TMED2/INSIG1/TAPBP/RAB8B/COG6/CREB3L2/AP3S1/SEC24A/SEC31A/WIPI1/SNAP23/LMAN1/KDELR2/DNM2/TMED3/TMED10/LAMP1/COPA/TMED7/ERGIC3/KDELR1/SEC16A/BCAP29/RNF139/ARF4/YIF1A/SCAMP1/SAR1A/COPG1/TMED9/USO1/AP1G1/ARCN1/ARFGAP3/SEC22B/YIPF5/LYPLA1/GOLPH3/KRT18/CUX1/LMAN2/NRBP1/ACSL3/MACF1 49 GO:0009101 glycoprotein biosynthetic process 50/852 317/18722 1.20743771902619e-14 1.28958694524062e-11 ITM2B/TCF7L2/MGAT5/CHPF/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/ABCA7/GALNT3/UGDH/SLC39A8/GALNT2/DSEL/TMEM59/HS6ST1/MGAT4A/B4GALT1/TET3/MAN2A1/MGAT1/KRTCAP2/MGAT2/RPN2/BMPR2/GFPT1/CTNNB1/CHPF2/RPN1/PGM3/STT3A/ST3GAL6/B4GALT4/MAN1B1/MGAT4B/B4GALT5/MAN1A2/GALNT1/MOGS/ITM2C/STT3B/DSE/TMEM258/EDEM3/NCSTN/DDOST/GOLPH3/EXT2/MAGT1 50 GO:0031589 cell-substrate adhesion 54/852 363/18722 1.2811314774892e-14 1.28958694524062e-11 FN1/SERPINE1/COL17A1/ITGA5/ITGB1/SFRP1/FBLN1/PTN/DOCK5/P4HB/SDC4/ACVRL1/ITGA1/PXN/SMAD3/ADAM15/LIMCH1/NTN4/PTK2B/FAT2/MYADM/FLNA/PARVA/CD63/LAMB2/PHLDB2/MMP14/EFNA1/SRGAP2/CALR/RHOD/TIAM1/ADAM9/CTNNB1/DNM2/DAG1/LAMA5/ATRN/PTK2/LRP1/PIK3CB/LAMC1/IQGAP1/ACTN4/CTTN/ARHGEF7/VCL/MDK/JUP/ID1/PIK3R1/RREB1/ACTN1/MACF1 54 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 31/852 130/18722 1.68758416701162e-14 1.41560185209492e-11 KDELR3/SEC24D/ERGIC1/SEC23A/TMED2/INSIG1/CREB3L2/SEC24A/SEC31A/LMAN1/KDELR2/TMED3/TMED10/COPA/TMED7/ERGIC3/KDELR1/SEC16A/BCAP29/RNF139/ARF4/YIF1A/SAR1A/COPG1/TMED9/USO1/ARCN1/SEC22B/YIPF5/LMAN2/NRBP1 31 GO:0001667 ameboidal-type cell migration 59/852 475/18722 2.24715235983124e-12 1.61570254671866e-09 FN1/SPARC/FSTL1/FGFR1/ITGB1/PTN/GATA3/TIMP1/PRCP/DOCK5/SDC4/ACVRL1/SEMA5A/PXN/ARHGDIB/GATA2/IQSEC1/SYDE1/TGFB1/EFNB1/TGFB2/PTK2B/FAT2/APOE/MAPRE2/SCARB1/EDNRB/GRN/SEMA4C/PLPP3/HSPB1/EFNA1/PKN1/SRGAP2/PLK2/SASH1/CALR/AMOTL2/BMPR2/ADAM9/HDAC5/MYH9/RTN4/TPBG/LAMA5/PTK2/EVL/PIK3CB/SEMA7A/P2RX4/CTSH/ARHGEF7/JUP/ID1/RREB1/ADAM17/EMC10/MACF1/DPP4 59 GO:0070085 glycosylation 39/852 240/18722 4.04256204647314e-12 2.54327684748742e-09 MGAT5/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/SLC39A8/GALNT2/TMEM59/MGAT4A/B4GALT1/TET3/MAN2A1/MGAT1/KRTCAP2/COG6/MGAT2/RPN2/GFPT1/GBA/RPN1/CLN5/PGM3/STT3A/ST3GAL6/B4GALT4/MAN1B1/MGAT4B/B4GALT5/MAN1A2/GALNT1/MOGS/STT3B/TMEM258/EDEM3/DDOST/EXT2/MAGT1 39 GO:0032970 regulation of actin filament-based process 52/852 396/18722 5.7418604533151e-12 3.21097596239277e-09 TPM1/SFRP1/F11R/COTL1/SDC4/SEMA5A/ASAP3/PAM/PXN/ARHGDIB/TMSB10/SMAD3/CAPG/LIMCH1/PTK2B/ESAM/BAIAP2L1/CDC42EP5/KCNJ2/MYADM/FLNA/LIMA1/PKP2/NOTCH2/CSF1R/PHLDB2/CNN2/VASP/RHOD/NCKAP1/DSG2/GJA5/MYH9/BST2/CDC42EP1/DSTN/LRP1/EVL/IQGAP1/CTTN/RHOBTB3/SSH2/MDK/JUP/ID1/PIK3R1/GSN/MYO1C/ABRACL/RHOC/SRI/RND3 52 GO:0034976 response to endoplasmic reticulum stress 40/852 256/18722 7.66573992721918e-12 3.85816690536941e-09 P4HB/RCN3/RASGRF2/ABCA7/XBP1/OS9/TMED2/WFS1/CANX/CALR/HSP90B1/ATF3/CREB3L2/HM13/FAM8A1/HERPUD1/SEC16A/MAN1B1/RNF139/PDIA3/SEL1L/SERINC3/DNAJC10/PPP1R15B/TP53/ERO1A/TMBIM6/PDIA4/STT3B/AMFR/EDEM3/PIK3R1/UBE2K/TMCO1/ATF4/SDF2L1/GORASP2/DNAJC3/TMEM259/ERP29 40 GO:0150115 cell-substrate junction organization 24/852 101/18722 1.68647312998306e-11 7.16545448749803e-09 FN1/COL17A1/SFRP1/SDC4/ACVRL1/IQSEC1/SMAD3/LIMCH1/PTK2B/MAPRE2/PHLDB2/MMP14/RAB8B/RHOD/PTK2/LRP1/LAMC1/IQGAP1/CTTN/ARHGEF7/VCL/PIK3R1/ACTN1/MACF1 24 GO:0022604 regulation of cell morphogenesis 44/852 309/18722 1.70843341645095e-11 7.16545448749803e-09 FN1/TPM1/SPARC/HEXB/FBLN1/PTN/DOCK5/F11R/P4HB/PLXNB2/FBLIM1/SLC23A2/PTK2B/MFSD2A/CDC42EP5/MYADM/FLNA/PARVA/RHOU/CSF1R/MYO10/CALR/RHOD/TIAM1/DNM2/MYH9/DAG1/CDC42SE1/CDC42EP1/SH3D19/PTK2/ACTN4/CDC42SE2/RHOBTB3/FMNL2/EZR/ARHGEF7/MDK/RREB1/CUX1/RHOC/OBSL1/MACF1/RND3 44 GO:0033619 membrane protein proteolysis 18/852 57/18722 3.40793498715883e-11 1.3193951377208e-08 TIMP3/TIMP2/ADAM19/TIMP1/TGFB1/APOE/ADAM10/ADAM9/MYH9/DAG1/HM13/SH3D19/ERAP1/FURIN/CTSH/NCSTN/PTPN3/ADAM17 18 GO:0006487 protein N-linked glycosylation 19/852 65/18722 4.44772841920557e-11 1.54222899503568e-08 MGAT5/SLC39A8/MGAT4A/B4GALT1/MGAT1/KRTCAP2/MGAT2/RPN2/GFPT1/RPN1/PGM3/STT3A/MGAT4B/MOGS/STT3B/TMEM258/DDOST/EXT2/MAGT1 19 GO:0006486 protein glycosylation 36/852 226/18722 4.90277447259506e-11 1.54222899503568e-08 MGAT5/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/SLC39A8/GALNT2/TMEM59/MGAT4A/B4GALT1/TET3/MAN2A1/MGAT1/KRTCAP2/MGAT2/RPN2/GFPT1/RPN1/PGM3/STT3A/ST3GAL6/B4GALT4/MAN1B1/MGAT4B/B4GALT5/MAN1A2/GALNT1/MOGS/STT3B/TMEM258/EDEM3/DDOST/EXT2/MAGT1 36 GO:0043413 macromolecule glycosylation 36/852 226/18722 4.90277447259506e-11 1.54222899503568e-08 MGAT5/PLOD3/B3GNT7/EXTL3/GALNT7/GALNT6/GALNT3/SLC39A8/GALNT2/TMEM59/MGAT4A/B4GALT1/TET3/MAN2A1/MGAT1/KRTCAP2/MGAT2/RPN2/GFPT1/RPN1/PGM3/STT3A/ST3GAL6/B4GALT4/MAN1B1/MGAT4B/B4GALT5/MAN1A2/GALNT1/MOGS/STT3B/TMEM258/EDEM3/DDOST/EXT2/MAGT1 36 GO:0090132 epithelium migration 46/852 360/18722 2.46742044330312e-10 7.30501593596741e-08 SPARC/FSTL1/FGFR1/ITGB1/PTN/GATA3/PRCP/DOCK5/ACVRL1/SEMA5A/PXN/GATA2/IQSEC1/TGFB1/TGFB2/PTK2B/FAT2/APOE/MAPRE2/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PKN1/PLK2/SASH1/CALR/BMPR2/GRHL2/ADAM9/HDAC5/MYH9/RTN4/PTK2/EVL/PIK3CB/P2RX4/CTSH/JUP/ID1/RREB1/ADAM17/EMC10/MACF1/DPP4 46 GO:0006509 membrane protein ectodomain proteolysis 15/852 43/18722 3.02181787240612e-10 8.44933852878889e-08 TIMP3/TIMP2/ADAM19/TIMP1/APOE/ADAM10/ADAM9/MYH9/DAG1/SH3D19/ERAP1/FURIN/NCSTN/PTPN3/ADAM17 15 GO:0030198 extracellular matrix organization 41/852 301/18722 3.38015832689033e-10 8.95386150486264e-08 QSOX1/COL17A1/COL4A2/COL4A1/ENG/ITGB1/FKBP10/FBLN1/ADAMTS1/MMP11/MMP2/PLOD3/SMAD3/COL27A1/ADAM15/SH3PXD2B/TGFB1/SLC39A8/CRISPLD2/TGFB2/NTN4/SERPINH1/P3H4/PRDX4/BMP1/B4GALT1/LAMB2/PHLDB2/MMP14/COLGALT1/LTBP3/ADAM10/DAG1/CAV2/P4HA1/LRP1/LAMC1/FURIN/ERO1A/SPINT1/DPP4 41 GO:0043062 extracellular structure organization 41/852 302/18722 3.74461516415394e-10 9.36797159849611e-08 QSOX1/COL17A1/COL4A2/COL4A1/ENG/ITGB1/FKBP10/FBLN1/ADAMTS1/MMP11/MMP2/PLOD3/SMAD3/COL27A1/ADAM15/SH3PXD2B/TGFB1/SLC39A8/CRISPLD2/TGFB2/NTN4/SERPINH1/P3H4/PRDX4/BMP1/B4GALT1/LAMB2/PHLDB2/MMP14/COLGALT1/LTBP3/ADAM10/DAG1/CAV2/P4HA1/LRP1/LAMC1/FURIN/ERO1A/SPINT1/DPP4 41 GO:0090130 tissue migration 46/852 365/18722 3.90875031926124e-10 9.36797159849611e-08 SPARC/FSTL1/FGFR1/ITGB1/PTN/GATA3/PRCP/DOCK5/ACVRL1/SEMA5A/PXN/GATA2/IQSEC1/TGFB1/TGFB2/PTK2B/FAT2/APOE/MAPRE2/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PKN1/PLK2/SASH1/CALR/BMPR2/GRHL2/ADAM9/HDAC5/MYH9/RTN4/PTK2/EVL/PIK3CB/P2RX4/CTSH/JUP/ID1/RREB1/ADAM17/EMC10/MACF1/DPP4 46 GO:0045229 external encapsulating structure organization 41/852 304/18722 4.58852898844301e-10 1.02642856034799e-07 QSOX1/COL17A1/COL4A2/COL4A1/ENG/ITGB1/FKBP10/FBLN1/ADAMTS1/MMP11/MMP2/PLOD3/SMAD3/COL27A1/ADAM15/SH3PXD2B/TGFB1/SLC39A8/CRISPLD2/TGFB2/NTN4/SERPINH1/P3H4/PRDX4/BMP1/B4GALT1/LAMB2/PHLDB2/MMP14/COLGALT1/LTBP3/ADAM10/DAG1/CAV2/P4HA1/LRP1/LAMC1/FURIN/ERO1A/SPINT1/DPP4 41 GO:0034446 substrate adhesion-dependent cell spreading 23/852 108/18722 4.69061332962523e-10 1.02642856034799e-07 FN1/FBLN1/DOCK5/P4HB/PXN/NTN4/MYADM/FLNA/PARVA/LAMB2/EFNA1/SRGAP2/CALR/DNM2/LAMA5/ATRN/PTK2/LAMC1/ACTN4/ARHGEF7/MDK/PIK3R1/RREB1 23 GO:0010631 epithelial cell migration 45/852 357/18722 6.04398136818781e-10 1.26747325942038e-07 SPARC/FSTL1/FGFR1/ITGB1/PTN/GATA3/PRCP/DOCK5/ACVRL1/SEMA5A/PXN/GATA2/IQSEC1/TGFB1/TGFB2/PTK2B/FAT2/APOE/MAPRE2/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PKN1/PLK2/SASH1/CALR/BMPR2/ADAM9/HDAC5/MYH9/RTN4/PTK2/EVL/PIK3CB/P2RX4/CTSH/JUP/ID1/RREB1/ADAM17/EMC10/MACF1/DPP4 45 GO:0018126 protein hydroxylation 12/852 27/18722 6.75503029428189e-10 1.35992269884483e-07 EGLN3/FKBP10/P4HB/PLOD3/PLOD2/PLOD1/P4HA2/P3H4/PRDX4/P3H1/P4HA1/ERO1A 12 GO:0019082 viral protein processing 12/852 29/18722 1.85343850530571e-09 3.5878292296937e-07 MGAT5/MGAT4A/MAN2A1/MGAT1/MGAT2/CANX/MAN1B1/MGAT4B/FURIN/GALNT1/MOGS/SPCS3 12 GO:0034975 protein folding in endoplasmic reticulum 8/852 11/18722 2.60157732380443e-09 4.84222124705084e-07 P4HB/CANX/CALR/HSP90B1/PDIA3/DNAJC10/ERO1A/DNAJC3 8 GO:0007015 actin filament organization 50/852 441/18722 2.69386439335235e-09 4.84222124705084e-07 TPM1/SFRP1/CORO6/F11R/COTL1/SDC4/SEMA5A/ASAP3/PXN/AIF1L/TMSB10/SMAD3/CAPG/LIMCH1/PTK2B/ESAM/TPM2/BAIAP2L1/CDC42EP5/HIP1/MYADM/FLNA/LIMA1/PHLDB2/FAT1/VASP/ARHGEF2/CALD1/HSP90B1/RHOD/NCKAP1/CDC42EP1/DSTN/EVL/MPRIP/MYO6/CTTN/RHOBTB3/SSH2/TTC17/INPPL1/MICAL3/EZR/ID1/PIK3R1/GSN/ACTN1/MYO1C/RHOC/RND3 50 GO:0034109 homotypic cell-cell adhesion 20/852 90/18722 2.90134223891607e-09 5.0353294787809e-07 FN1/SERPINE2/IL6ST/CD9/F11R/FLNA/PKP2/ACTB/PLPP3/HSPB1/DSG2/MYH9/UBASH3B/JAK1/PIK3CB/ZNF703/TJP2/VCL/JUP/CSRP1 20 GO:0070972 protein localization to endoplasmic reticulum 18/852 74/18722 3.8428931398856e-09 6.33000264505335e-07 KDELR3/OS9/INSIG1/KDELR2/RTN4/SEC61A1/SSR3/SEC61G/HERPUD1/KDELR1/SEC16A/SEC62/BCAP29/TRAM2/TRAM1/SPCS3/SEC63/GPAA1 18 GO:0042063 gliogenesis 39/852 301/18722 3.89886910384768e-09 6.33000264505335e-07 SERPINE2/IL6ST/HEXB/ASCL2/NOG/PTN/CD9/TSPO/GCM1/ERBB2/METRN/TGFB1/TGFB2/PTK2B/SOX4/GRN/LAMB2/MMP14/SRGAP2C/SRGAP2/TIAM1/CTNNB1/GBA/RTN4/DAG1/LDLR/NDRG1/ERBB3/LRP1/GPC1/MAPK3/MYCN/SUN2/B4GALT5/P2RX4/MDK/RHEB/NCSTN/SPINT1 39 GO:0032956 regulation of actin cytoskeleton organization 43/852 357/18722 5.88259439628003e-09 9.25221799889918e-07 TPM1/SFRP1/F11R/COTL1/SDC4/SEMA5A/ASAP3/PAM/PXN/ARHGDIB/TMSB10/SMAD3/CAPG/LIMCH1/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/FLNA/LIMA1/NOTCH2/CSF1R/PHLDB2/VASP/RHOD/NCKAP1/BST2/CDC42EP1/DSTN/LRP1/EVL/IQGAP1/CTTN/RHOBTB3/SSH2/MDK/ID1/PIK3R1/GSN/MYO1C/RHOC/RND3 43 GO:0010810 regulation of cell-substrate adhesion 32/852 221/18722 6.61466629540397e-09 1.0088368322657e-06 FN1/SERPINE1/SFRP1/FBLN1/PTN/DOCK5/P4HB/SDC4/ACVRL1/SMAD3/ADAM15/LIMCH1/PTK2B/MYADM/FLNA/PHLDB2/MMP14/CALR/DNM2/DAG1/PTK2/LRP1/PIK3CB/IQGAP1/ACTN4/ARHGEF7/VCL/MDK/JUP/PIK3R1/RREB1/MACF1 32 GO:0007044 cell-substrate junction assembly 20/852 95/18722 7.85235193299408e-09 1.16237903761056e-06 FN1/COL17A1/SFRP1/SDC4/ACVRL1/SMAD3/LIMCH1/PTK2B/PHLDB2/MMP14/RHOD/PTK2/LRP1/LAMC1/IQGAP1/CTTN/ARHGEF7/VCL/ACTN1/MACF1 20 GO:1901342 regulation of vasculature development 42/852 348/18722 8.34254437978763e-09 1.19965788181346e-06 FLT1/SERPINE1/SPARC/HSPG2/ADAM12/HLA-G/COL4A2/ITGA5/ENG/ITGB1/SFRP1/ADM/PTN/ADAMTS1/ACVRL1/SEMA5A/ERBB2/GATA2/ANGPTL4/TGFB2/PTK2B/GRN/XBP1/PGF/HSPB1/EFNA1/TNFAIP3/PLK2/SASH1/ADAM10/MTDH/CTNNB1/JAK1/PIK3CB/ERAP1/CTSH/MYDGF/MDK/JUP/ID1/EPN2/EMC10 42 GO:0001701 in utero embryonic development 43/852 367/18722 1.34583019927106e-08 1.88154538692535e-06 IGF2/EPAS1/ASCL2/NOG/ITGB1/ADM/FKBP10/CITED2/GATA3/KRT19/PLOD3/GCM1/ACVRL1/GATA2/SH3PXD2A/CMTM3/SMAD3/PLCD3/ATP11A/KRT8/SEC24D/ENDOG/NOTCH2/MAN2A1/MGAT1/TMED2/ADAM10/GRHL2/CTNNB1/SMIM14/MYH9/RTN4/NCOA1/HM13/ZFP36L1/CAPN2/CMIP/FURIN/RDH10/TP53/SPINT1/UBE2A/MBD3 43 GO:0010632 regulation of epithelial cell migration 37/852 292/18722 1.78375117979981e-08 2.42638369944121e-06 SPARC/FGFR1/PTN/GATA3/PRCP/DOCK5/ACVRL1/SEMA5A/GATA2/IQSEC1/TGFB1/TGFB2/PTK2B/APOE/MAPRE2/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PLK2/SASH1/CALR/BMPR2/ADAM9/HDAC5/RTN4/PTK2/EVL/PIK3CB/P2RX4/CTSH/JUP/RREB1/ADAM17/EMC10/MACF1 37 GO:0050679 positive regulation of epithelial cell proliferation 30/852 207/18722 1.91644269012076e-08 2.53827791036257e-06 IGF2/HTRA1/FGFR1/NOG/SFRP1/TCF7L2/PTN/ACVRL1/SEMA5A/ERBB2/GATA2/GRN/XBP1/B4GALT1/NOTCH2/PGF/TNFAIP3/BMPR2/CTNNB1/RTN4/CAV2/LAMC1/SRSF6/MYDGF/ZNF703/MDK/ID1/RREB1/ADAM17/EMC10 30 GO:0007160 cell-matrix adhesion 32/852 233/18722 2.42258813626996e-08 3.12638104867864e-06 FN1/SERPINE1/COL17A1/ITGB1/SFRP1/SDC4/ACVRL1/ITGA1/PXN/SMAD3/ADAM15/LIMCH1/PTK2B/CD63/PHLDB2/MMP14/RHOD/TIAM1/ADAM9/CTNNB1/DAG1/PTK2/LRP1/PIK3CB/IQGAP1/CTTN/ARHGEF7/VCL/JUP/PIK3R1/ACTN1/MACF1 32 GO:0010634 positive regulation of epithelial cell migration 27/852 176/18722 2.90863923593626e-08 3.6597953186168e-06 SPARC/FGFR1/GATA3/DOCK5/SEMA5A/GATA2/IQSEC1/TGFB1/TGFB2/PTK2B/MAPRE2/SCARB1/GRN/PLPP3/HSPB1/PLK2/SASH1/CALR/BMPR2/ADAM9/RTN4/PIK3CB/P2RX4/CTSH/RREB1/ADAM17/EMC10 27 GO:0008360 regulation of cell shape 25/852 154/18722 2.99478286883111e-08 3.6762785802017e-06 FN1/TPM1/HEXB/PTN/F11R/PLXNB2/FBLIM1/PTK2B/CDC42EP5/PARVA/RHOU/CSF1R/MYO10/RHOD/MYH9/DAG1/CDC42SE1/CDC42EP1/PTK2/CDC42SE2/RHOBTB3/FMNL2/EZR/RHOC/RND3 25 GO:0045185 maintenance of protein location 19/852 93/18722 3.10991335252e-08 3.72671283410313e-06 LTBP1/FBN1/TSPO/KDELR3/TMSB10/FLNA/OS9/SYNE1/INSIG1/KDELR2/PINK1/TXN/KDELR1/FBN2/SUN2/GSN/GOLPH3/SRI/GPAA1 19 GO:0048762 mesenchymal cell differentiation 32/852 236/18722 3.29907952765558e-08 3.83134816300815e-06 FN1/ENG/FGFR1/NOG/SFRP1/TCF7L2/CITED2/GATA3/SEMA5A/SMAD3/WWTR1/ADAM15/TGFB1/EFNB1/TGFB2/FLNA/EDNRB/SEMA4C/PHLDB2/EFNA1/TIAM1/CTNNB1/RTN4/DAG1/LAMA5/SEMA7A/MAPK3/RDH10/ZNF703/MDK/DDX17/TGFBR3 32 GO:0001890 placenta development 24/852 144/18722 3.34947981665724e-08 3.83134816300815e-06 IGF2/HTRA1/EPAS1/ASCL2/ADAM19/ADM/CITED2/PTN/KRT19/GCM1/GATA2/PLCD3/KRT8/NOTCH2/TMED2/CTSB/BMPR2/GRHL2/NCOA1/ZFP36L1/PTK2/MAPK3/BSG/SPINT1 24 GO:0050678 regulation of epithelial cell proliferation 43/852 381/18722 4.03690527572675e-08 4.51505427838505e-06 IGF2/FLT1/HTRA1/SPARC/FGFR1/NOG/SFRP1/TCF7L2/PTN/GATA3/ACVRL1/SEMA5A/ERBB2/GATA2/SMAD3/TGFB1/TGFB2/APOE/CDKN1C/EDNRB/GRN/XBP1/B4GALT1/NOTCH2/PGF/TNFAIP3/BMPR2/CTNNB1/RTN4/CAV2/ZFP36L1/MAGED1/LAMC1/SRSF6/MYDGF/ZNF703/MDK/ID1/RREB1/ERRFI1/ADAM17/EMC10/TGFBR3 43 GO:0150172 regulation of phosphatidylcholine metabolic process 7/852 10/18722 4.19820069080798e-08 4.59337914713838e-06 APOC1/LPCAT1/MFSD2A/SCARB1/LDLR/CAPN2/ACSL3 7 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 41/852 355/18722 4.39564659910523e-08 4.70708283687162e-06 FSTL3/HTRA1/HPGD/HTRA4/FSTL1/LTBP1/ENG/FBN1/NOG/SFRP1/CITED2/GDF15/ACVRL1/PXN/SMAD3/WWTR1/TGFB1/TGFB2/INHA/CDKN1C/PCSK6/NOTCH2/CRIM1/LTBP3/BMPR2/ADAM9/DNM2/CAV2/EGR1/PTK2/LRP1/MAPK3/FBN2/FURIN/TP53/XIAP/ZNF703/ID1/ADAM17/TGFBR3/RBPMS 41 GO:0045765 regulation of angiogenesis 40/852 342/18722 4.53948989501435e-08 4.75984430033484e-06 FLT1/SERPINE1/SPARC/HSPG2/ADAM12/HLA-G/COL4A2/ITGA5/ENG/ITGB1/SFRP1/ADM/PTN/ADAMTS1/ACVRL1/SEMA5A/ERBB2/GATA2/ANGPTL4/TGFB2/PTK2B/GRN/XBP1/PGF/HSPB1/EFNA1/TNFAIP3/PLK2/SASH1/MTDH/CTNNB1/JAK1/PIK3CB/ERAP1/CTSH/MYDGF/MDK/JUP/EPN2/EMC10 40 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 14/852 52/18722 5.17275307464374e-08 5.31315637238407e-06 KDELR3/ERGIC1/PLPP3/TAPBP/KDELR2/TMED10/COPA/ERGIC3/KDELR1/ARF4/ARCN1/SEC22B/GOLPH3/LMAN2 14 GO:0034329 cell junction assembly 45/852 420/18722 9.17858809542801e-08 9.23916677685784e-06 FN1/COL17A1/SFRP1/IL1RAP/CD9/F11R/CLDN19/SDC4/ACVRL1/PDLIM5/PLXNB2/PTPRS/SMAD3/LIMCH1/PTK2B/GPC4/ESAM/EPHB2/PKP2/PHLDB2/ACTB/MMP14/RHOD/GRHL2/MTDH/CTNNB1/GJA5/TPBG/PTK2/LRP1/LAMC1/IQGAP1/CTTN/NPTN/LSR/ZNF703/ARHGEF7/VCL/JUP/ACTN1/PKP3/MYO1C/RHOC/OBSL1/MACF1 45 GO:0010720 positive regulation of cell development 36/852 298/18722 9.47974405861208e-08 9.35520624450875e-06 FN1/SERPINE2/IL6ST/PTN/DOCK5/F11R/P4HB/TSPO/SEMA5A/PLXNB2/CRABP2/METRN/TGFB1/EPHB2/MYADM/FLNA/MAN2A1/CALR/BMPR2/TIAM1/CTNNB1/DNM2/EIF4G2/DAG1/LRP1/SEMA7A/NPTN/ARHGEF7/MDK/RHEB/RREB1/SPINT1/CUX1/OBSL1/MACF1/ATP6AP1 36 GO:0050673 epithelial cell proliferation 46/852 437/18722 1.11683143572639e-07 1.08096396461748e-05 IGF2/FLT1/HTRA1/SPARC/FGFR1/NOG/SFRP1/TCF7L2/PTN/GATA3/ACVRL1/SEMA5A/ERBB2/GATA2/SMAD3/TGFB1/TGFB2/APOE/SCARB1/CDKN1C/EDNRB/GRN/XBP1/B4GALT1/NOTCH2/PGF/MMP14/TNFAIP3/BMPR2/CTNNB1/RTN4/CAV2/ZFP36L1/MAGED1/LAMC1/SRSF6/MYDGF/ZNF703/MDK/NCSTN/ID1/RREB1/ERRFI1/ADAM17/EMC10/TGFBR3 46 GO:0048608 reproductive structure development 45/852 424/18722 1.2100728723921e-07 1.14911259749989e-05 SERPINE2/FSTL3/IGF2/HTRA1/TNFSF10/EPAS1/ASCL2/ADAM19/NOG/NRIP1/SFRP1/ADM/CITED2/PTN/GATA3/ADAMTS1/KRT19/GCM1/PSAP/GATA2/ADAM15/TGFB2/PLCD3/INHA/KRT8/FLNA/PRDX4/NOTCH2/MMP14/TMED2/CTSB/BMPR2/GRHL2/SDC1/CTNNB1/NCOA1/PLEKHA1/ZFP36L1/PTK2/MAPK3/RHOBTB3/BSG/RDH10/TFAP2C/SPINT1 45 GO:0061458 reproductive system development 45/852 427/18722 1.48443725651741e-07 1.38355050223187e-05 SERPINE2/FSTL3/IGF2/HTRA1/TNFSF10/EPAS1/ASCL2/ADAM19/NOG/NRIP1/SFRP1/ADM/CITED2/PTN/GATA3/ADAMTS1/KRT19/GCM1/PSAP/GATA2/ADAM15/TGFB2/PLCD3/INHA/KRT8/FLNA/PRDX4/NOTCH2/MMP14/TMED2/CTSB/BMPR2/GRHL2/SDC1/CTNNB1/NCOA1/PLEKHA1/ZFP36L1/PTK2/MAPK3/RHOBTB3/BSG/RDH10/TFAP2C/SPINT1 45 GO:1903034 regulation of response to wounding 25/852 167/18722 1.53258839755697e-07 1.40245770998259e-05 SERPINE2/SERPINE1/PTPRF/SERPING1/TFPI/ITGB1/PTN/CD9/CLDN19/PTPRS/SMAD3/APOE/EPHB2/FLNA/GRN/XBP1/PHLDB2/PLPP3/TNFAIP3/UBASH3B/PTK2/LRP1/SRSF6/MDK/RREB1 25 GO:0090287 regulation of cellular response to growth factor stimulus 36/852 304/18722 1.56619808665683e-07 1.40427972335561e-05 FSTL3/HTRA1/HTRA4/FSTL1/ITGA5/LTBP1/ENG/FBN1/FGFR1/NOG/SFRP1/CITED2/GATA3/ACVRL1/SMAD3/TGFB1/CDKN1C/PCSK6/CD63/NOTCH2/CRIM1/BMPR2/CTNNB1/DNM2/CAV2/PIK3CB/GPC1/FBN2/NPTN/TP53/XIAP/ZNF703/MYO1C/EPN2/ADAM17/TGFBR3 36 GO:0060485 mesenchyme development 35/852 291/18722 1.59038236104251e-07 1.40427972335561e-05 FN1/ENG/FGFR1/NOG/SFRP1/TCF7L2/CITED2/GATA3/ACVRL1/SEMA5A/SMAD3/WWTR1/ADAM15/TGFB1/EFNB1/TGFB2/FLNA/EDNRB/SEMA4C/PHLDB2/EFNA1/BMPR2/TIAM1/CTNNB1/RTN4/DAG1/LAMA5/ZFP36L1/SEMA7A/MAPK3/RDH10/ZNF703/MDK/DDX17/TGFBR3 35 GO:0016032 viral process 44/852 415/18722 1.72122455628275e-07 1.49360744685709e-05 ITGA5/ITGB1/MGAT5/F11R/P4HB/IFI27/PVR/APOE/SCARB1/CTSL/MGAT4A/MAN2A1/MGAT1/ISG15/INSR/MGAT2/CTSB/CANX/SLC1A5/SCARB2/PPIB/CTBP2/PABPC1/DAG1/LAMP1/BST2/LDLR/CAV2/IGF2R/MAN1B1/MGAT4B/BSG/RXRA/FURIN/ARL8B/GALNT1/TP53/MOGS/DDB1/GSN/SPCS3/FMR1/PCBP2/DPP4 44 GO:0001666 response to hypoxia 36/852 307/18722 2.00113128618018e-07 1.70706673954997e-05 EGLN3/EPAS1/ASCL2/SFRP1/ADM/CITED2/PTN/MMP2/P4HB/ACVRL1/PLOD2/PAM/PLOD1/ANGPTL4/SMAD3/ADAM15/TGFB2/PTK2B/ENDOG/PGF/MMP14/SOD3/EIF4EBP1/HSP90B1/PINK1/ZFP36L1/EGR1/NDRG1/CAPN2/ITPR2/TP53/ERO1A/TMBIM6/ADAM17/TGFBR3/DPP4 36 GO:0051604 protein maturation 35/852 294/18722 2.04463301665401e-07 1.71510632880327e-05 SERPINE2/SERPINE1/ADAM19/IL1R2/GALNT2/PCSK1N/SOX4/TMEM59/SERPINH1/CPM/CTSL/PRDX4/PCSK6/MMP14/WFS1/CALR/ADAM10/MYH9/TSPAN14/HM13/CLN5/CTSZ/TBC1D10A/RNF139/CAPN2/FURIN/LMF2/CTSH/XIAP/ERO1A/DDI2/NCSTN/GSN/SPCS3/ADAM17 35 GO:0044706 multi-multicellular organism process 29/852 220/18722 2.66252247379682e-07 2.19679928042941e-05 SERPINE2/TAC3/PAPPA/HPGD/HEXB/ADM/FBLN1/CITED2/PSG2/PTN/TIMP1/MMP2/PAM/ARHGDIB/SYDE1/PSG5/B4GALT1/PGF/TMED2/CTSB/CALR/BMPR2/ADCY7/ACSL4/FOSB/MAPK3/CAPN2/BSG/UBE2A 29 GO:0007229 integrin-mediated signaling pathway 19/852 107/18722 3.22333919190333e-07 2.58726893263952e-05 FN1/ITGA5/ITGB1/PTN/ADAMTS1/TIMP1/ITGA1/ADAM15/PTK2B/FLNA/CD63/PLPP3/ISG15/ADAM10/ADAM9/MYH9/LAMA5/PTK2/SEMA7A 19 GO:0048041 focal adhesion assembly 17/852 87/18722 3.2385841994097e-07 2.58726893263952e-05 SFRP1/SDC4/ACVRL1/SMAD3/LIMCH1/PTK2B/PHLDB2/MMP14/RHOD/PTK2/LRP1/IQGAP1/CTTN/ARHGEF7/VCL/ACTN1/MACF1 17 GO:0018279 protein N-linked glycosylation via asparagine 9/852 23/18722 3.68582239676311e-07 2.89855376920449e-05 MGAT5/MGAT1/MGAT2/RPN2/RPN1/STT3A/STT3B/DDOST/MAGT1 9 GO:0050921 positive regulation of chemotaxis 22/852 141/18722 4.07484380417267e-07 3.15518290252324e-05 SERPINE1/FGFR1/PTN/SEMA5A/PLA2G7/SMAD3/TGFB1/PTK2B/CCR1/PGF/CSF1R/HSPB1/CALR/ADAM10/BMPR2/TIAM1/TPBG/PTK2/MAPK3/P2RX4/MDK/ADAM17 22 GO:0051897 positive regulation of protein kinase B signaling 20/852 120/18722 4.61065306208922e-07 3.51597225174167e-05 IGF2/ENG/FGFR1/ITGB1/TCF7L2/GATA3/GDF15/SEMA5A/TGFB1/HIP1/INSR/MTDH/RTN4/TPBG/PINK1/TXN/PTK2/PIK3CB/P2RX4/MYDGF 20 GO:0030324 lung development 25/852 177/18722 4.76248418591466e-07 3.57754968771768e-05 FSTL3/SPARC/EPAS1/NOG/PTN/PLOD3/RCN3/CRISPLD2/MMP14/MAN2A1/EIF4EBP1/LTBP3/BMPR2/GRHL2/CTNNB1/DAG1/CTSZ/LAMA5/MAPK3/MYCN/MAN1A2/SRSF6/RDH10/CTSH/ERRFI1 25 GO:0008347 glial cell migration 13/852 53/18722 5.08028898900666e-07 3.76016095318684e-05 HEXB/CD9/TSPO/TGFB2/MMP14/SRGAP2C/SRGAP2/TIAM1/CTNNB1/RTN4/LRP1/SUN2/P2RX4 13 GO:0043542 endothelial cell migration 33/852 279/18722 5.26652128945605e-07 3.84150748548294e-05 SPARC/FSTL1/FGFR1/ITGB1/PTN/GATA3/PRCP/ACVRL1/SEMA5A/PXN/GATA2/TGFB1/PTK2B/APOE/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PLK2/SASH1/CALR/BMPR2/HDAC5/MYH9/PTK2/PIK3CB/P2RX4/JUP/ID1/ADAM17/EMC10/DPP4 33 GO:0150116 regulation of cell-substrate junction organization 15/852 71/18722 5.53448017064344e-07 3.97929124269263e-05 SFRP1/SDC4/ACVRL1/IQSEC1/SMAD3/LIMCH1/MAPRE2/PHLDB2/MMP14/PTK2/LRP1/IQGAP1/VCL/PIK3R1/MACF1 15 GO:0018196 peptidyl-asparagine modification 9/852 24/18722 5.65954403828983e-07 4.01189931615672e-05 MGAT5/MGAT1/MGAT2/RPN2/RPN1/STT3A/STT3B/DDOST/MAGT1 9 GO:0036293 response to decreased oxygen levels 36/852 322/18722 6.4395635572079e-07 4.5014338032538e-05 EGLN3/EPAS1/ASCL2/SFRP1/ADM/CITED2/PTN/MMP2/P4HB/ACVRL1/PLOD2/PAM/PLOD1/ANGPTL4/SMAD3/ADAM15/TGFB2/PTK2B/ENDOG/PGF/MMP14/SOD3/EIF4EBP1/HSP90B1/PINK1/ZFP36L1/EGR1/NDRG1/CAPN2/ITPR2/TP53/ERO1A/TMBIM6/ADAM17/TGFBR3/DPP4 36 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 31/852 256/18722 6.9511903828108e-07 4.65058977390741e-05 FSTL3/HTRA1/HTRA4/FSTL1/LTBP1/ENG/FBN1/NOG/SFRP1/CITED2/GDF15/ACVRL1/SMAD3/TGFB1/TGFB2/INHA/CDKN1C/PCSK6/NOTCH2/CRIM1/BMPR2/DNM2/CAV2/LRP1/FBN2/TP53/XIAP/ZNF703/ADAM17/TGFBR3/RBPMS 31 GO:0051017 actin filament bundle assembly 23/852 157/18722 7.06844126311738e-07 4.65058977390741e-05 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/AIF1L/SMAD3/LIMCH1/PTK2B/BAIAP2L1/FLNA/LIMA1/PHLDB2/CALD1/HSP90B1/RHOD/EVL/EZR/ID1/PIK3R1/ACTN1/RHOC 23 GO:0007565 female pregnancy 26/852 193/18722 7.1832977148728e-07 4.65058977390741e-05 TAC3/PAPPA/HPGD/ADM/FBLN1/CITED2/PSG2/PTN/TIMP1/MMP2/PAM/ARHGDIB/SYDE1/PSG5/PGF/TMED2/CTSB/CALR/BMPR2/ADCY7/ACSL4/FOSB/MAPK3/CAPN2/BSG/UBE2A 26 GO:0045785 positive regulation of cell adhesion 44/852 437/18722 7.2545211501206e-07 4.65058977390741e-05 FN1/FSTL3/IGF2/TPM1/EBI3/IL6ST/HLA-G/ADAM19/SFRP1/CITED2/PTN/GATA3/DOCK5/F11R/P4HB/SDC4/ERBB2/CD276/SMAD3/EFNB1/TGFB2/PTK2B/SLC7A1/SOX4/MYADM/FLNA/XBP1/PLPP3/MYO10/CALR/RHOD/ADAM9/DNM2/DAG1/JAK1/IQGAP1/PPP3CA/ARHGEF7/MDK/JUP/HSPH1/RREB1/NFAT5/DPP4 44 GO:0030323 respiratory tube development 25/852 181/18722 7.29975346987255e-07 4.65058977390741e-05 FSTL3/SPARC/EPAS1/NOG/PTN/PLOD3/RCN3/CRISPLD2/MMP14/MAN2A1/EIF4EBP1/LTBP3/BMPR2/GRHL2/CTNNB1/DAG1/CTSZ/LAMA5/MAPK3/MYCN/MAN1A2/SRSF6/RDH10/CTSH/ERRFI1 25 GO:0045766 positive regulation of angiogenesis 25/852 181/18722 7.29975346987255e-07 4.65058977390741e-05 FLT1/SERPINE1/ADAM12/ITGA5/ENG/ITGB1/ADM/ACVRL1/SEMA5A/GATA2/ANGPTL4/PTK2B/GRN/XBP1/PGF/HSPB1/SASH1/MTDH/JAK1/ERAP1/CTSH/MYDGF/MDK/JUP/EMC10 25 GO:1904018 positive regulation of vasculature development 25/852 181/18722 7.29975346987255e-07 4.65058977390741e-05 FLT1/SERPINE1/ADAM12/ITGA5/ENG/ITGB1/ADM/ACVRL1/SEMA5A/GATA2/ANGPTL4/PTK2B/GRN/XBP1/PGF/HSPB1/SASH1/MTDH/JAK1/ERAP1/CTSH/MYDGF/MDK/JUP/EMC10 25 GO:0032507 maintenance of protein location in cell 14/852 64/18722 8.414493874132e-07 5.2937684585633e-05 TSPO/KDELR3/TMSB10/OS9/SYNE1/INSIG1/KDELR2/PINK1/TXN/KDELR1/SUN2/GSN/GOLPH3/GPAA1 14 GO:0003007 heart morphogenesis 30/852 246/18722 9.02117288753002e-07 5.60537816579489e-05 TPM1/ENG/NOG/CITED2/GATA3/ADAMTS1/ACVRL1/SMAD3/ADAM15/TGFB1/TGFB2/SOX4/FLNA/PARVA/GAA/PKP2/NOTCH2/TMED2/EFNA1/INSR/BMPR2/GRHL2/FHL2/DHRS3/CTNNB1/GJA5/RTN4/PTK2/TP53/TGFBR3 30 GO:0045936 negative regulation of phosphate metabolic process 44/852 441/18722 9.29522184034691e-07 5.70522579542268e-05 IGFBP3/ENG/NOG/SFRP1/MGAT5/FBLN1/SH3BP5/PRKAG2/APOC1/WWTR1/CAMK2N1/TGFB1/GPRC5A/LPCAT1/TGFB2/APOE/INHA/EPHB2/MYADM/CDKN1C/SMYD3/PLPP3/HSPB1/TMED2/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/LRP1/PIK3CB/LGALS3/CTDSP1/PRKAR2A/HIPK3/DNAJC10/PPP1R15B/TP53/GNAQ/ERRFI1/IPO7/DNAJC3 44 GO:0010563 negative regulation of phosphorus metabolic process 44/852 442/18722 9.88323626326375e-07 5.97483759803011e-05 IGFBP3/ENG/NOG/SFRP1/MGAT5/FBLN1/SH3BP5/PRKAG2/APOC1/WWTR1/CAMK2N1/TGFB1/GPRC5A/LPCAT1/TGFB2/APOE/INHA/EPHB2/MYADM/CDKN1C/SMYD3/PLPP3/HSPB1/TMED2/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/LRP1/PIK3CB/LGALS3/CTDSP1/PRKAR2A/HIPK3/DNAJC10/PPP1R15B/TP53/GNAQ/ERRFI1/IPO7/DNAJC3 44 GO:0006986 response to unfolded protein 21/852 137/18722 1.00371679151933e-06 5.97483759803011e-05 ABCA7/SERPINH1/XBP1/OS9/HSPB1/TMED2/WFS1/ATF3/CREB3L2/HERPUD1/PPP1R15B/ERO1A/TMBIM6/STT3B/AMFR/EDEM3/TRAM1/HSPH1/PIK3R1/ATF4/DNAJC3 21 GO:0001933 negative regulation of protein phosphorylation 37/852 342/18722 1.00906257864605e-06 5.97483759803011e-05 IGFBP3/ENG/NOG/SFRP1/FBLN1/SH3BP5/PRKAG2/WWTR1/CAMK2N1/TGFB1/GPRC5A/APOE/EPHB2/MYADM/CDKN1C/SMYD3/PLPP3/HSPB1/TMED2/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/LRP1/PIK3CB/CTDSP1/PRKAR2A/HIPK3/DNAJC10/PPP1R15B/GNAQ/ERRFI1/IPO7/DNAJC3 37 GO:0061572 actin filament bundle organization 23/852 161/18722 1.10902028559793e-06 6.49034778769113e-05 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/AIF1L/SMAD3/LIMCH1/PTK2B/BAIAP2L1/FLNA/LIMA1/PHLDB2/CALD1/HSP90B1/RHOD/EVL/EZR/ID1/PIK3R1/ACTN1/RHOC 23 GO:0007179 transforming growth factor beta receptor signaling pathway 26/852 198/18722 1.17888936817321e-06 6.81994274714457e-05 HTRA1/HPGD/HTRA4/LTBP1/ENG/FBN1/CITED2/GDF15/ACVRL1/PXN/SMAD3/TGFB1/TGFB2/CDKN1C/LTBP3/ADAM9/DNM2/CAV2/PTK2/FBN2/FURIN/TP53/ZNF703/ID1/ADAM17/TGFBR3 26 GO:0110053 regulation of actin filament organization 32/852 277/18722 1.31459744530643e-06 7.5186010707128e-05 TPM1/SFRP1/F11R/COTL1/SDC4/SEMA5A/ASAP3/PXN/TMSB10/SMAD3/CAPG/LIMCH1/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/FLNA/LIMA1/PHLDB2/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/SSH2/ID1/PIK3R1/GSN/MYO1C/RHOC 32 GO:0045216 cell-cell junction organization 26/852 200/18722 1.42957411066293e-06 8.00681709055194e-05 CD9/F11R/CLDN19/SMAD3/TGFB1/TGFB2/ESAM/FLNA/PKP2/CSF1R/ACTB/ADAM10/GRHL2/MTDH/CTNNB1/DSG2/GJA5/LSR/ZNF703/TJP2/VCL/JUP/PKP3/MYO1C/RHOC/GRHL1 26 GO:0070482 response to oxygen levels 37/852 347/18722 1.43177734581696e-06 8.00681709055194e-05 EGLN3/EPAS1/ASCL2/SFRP1/ADM/CITED2/PTN/MMP2/P4HB/ACVRL1/PLOD2/PAM/PLOD1/ANGPTL4/SMAD3/ADAM15/TGFB2/PTK2B/ENDOG/PGF/MMP14/SOD3/EIF4EBP1/HSP90B1/PINK1/ZFP36L1/EGR1/NDRG1/CAPN2/ITPR2/TP53/ERO1A/TMBIM6/ADAM17/TGFBR3/ATP6AP1/DPP4 37 GO:0036503 ERAD pathway 18/852 107/18722 1.49154221489197e-06 8.2493757885179e-05 RCN3/OS9/WFS1/CANX/CALR/HSP90B1/HM13/FAM8A1/HERPUD1/MAN1B1/RNF139/SEL1L/DNAJC10/STT3B/AMFR/EDEM3/SDF2L1/TMEM259 18 GO:0018208 peptidyl-proline modification 13/852 58/18722 1.54311737034463e-06 8.44185839667885e-05 EGLN3/FKBP10/P4HB/P4HA2/FKBP11/PRDX4/P3H1/PPIC/FKBP9/PPIB/P4HA1/FKBP14/ERO1A 13 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 6/852 10/18722 1.56627461585214e-06 8.47640875439121e-05 EGLN3/P4HB/P4HA2/PRDX4/P4HA1/ERO1A 6 GO:0035459 vesicle cargo loading 9/852 27/18722 1.79326591498753e-06 9.60160356397047e-05 SEC24D/SEC23A/TMED2/INSIG1/SEC24A/SEC31A/PICALM/TMED10/SAR1A 9 GO:0050878 regulation of body fluid levels 39/852 379/18722 1.81402726280436e-06 9.61052548809929e-05 FN1/SERPINE2/SERPINE1/IL6ST/SERPING1/TFPI/ADM/FBLN1/CD9/F11R/PAM/PROCR/APOE/EPHB2/UGCG/FLNA/EDNRB/XBP1/ACTB/CD59/HSPB1/NCOR2/WFS1/GBA/LMAN1/GJA5/MYH9/UBASH3B/NCOA1/DGKZ/COPA/PIK3CB/VKORC1/LSR/GNAQ/VCL/CSRP1/EXT2/GRHL1 39 GO:0019511 peptidyl-proline hydroxylation 7/852 15/18722 1.84152026999441e-06 9.65455366550192e-05 EGLN3/P4HB/P4HA2/PRDX4/P3H1/P4HA1/ERO1A 7 GO:0072595 maintenance of protein localization in organelle 11/852 42/18722 1.90314889555452e-06 9.8747921560061e-05 TSPO/KDELR3/OS9/SYNE1/INSIG1/KDELR2/PINK1/TXN/KDELR1/SUN2/GPAA1 11 GO:0072659 protein localization to plasma membrane 32/852 284/18722 2.2618328140918e-06 0.000116161270952286 ITGB1/F11R/TGFB1/ARHGEF16/EPHB2/MYADM/TMEM59/FLNA/PKP2/ACTB/MMP14/SEC23A/TMED2/RAB8B/PICALM/TSPAN14/TPBG/LAMA5/LRP1/LGALS3/SEC16A/BSG/EZR/JUP/LYPLA1/PIK3R1/GOLPH3/KRT18/PKP3/GORASP2/ACSL3/MACF1 32 GO:0051235 maintenance of location 35/852 326/18722 2.34702461627867e-06 0.000118017634289092 HEXB/LTBP1/FBN1/NRIP1/TSPO/KDELR3/LPL/TMSB10/SLC30A2/PTK2B/APOE/SCARB1/FLNA/GAA/GM2A/OS9/SYNE1/INSIG1/ABCA1/CALR/HSP90B1/GBA/KDELR2/UBASH3B/PINK1/TXN/KDELR1/FBN2/SUN2/ITPR2/ERO1A/GSN/GOLPH3/SRI/GPAA1 35 GO:0035633 maintenance of blood-brain barrier 10/852 35/18722 2.34982060794307e-06 0.000118017634289092 ITGB1/F11R/JAM2/ESAM/MFSD2A/ACTB/LAMC1/LSR/TJP2/VCL 10 GO:0048568 embryonic organ development 42/852 427/18722 2.36832526588481e-06 0.000118017634289092 IGF2/MFAP5/EPAS1/ASCL2/ENG/TEAD1/FBN1/NOG/ADM/CITED2/GATA3/KRT19/MFAP2/GCM1/GATA2/SMAD3/TGFB1/TGFB2/PLCD3/EPHB2/ID3/KRT8/NOTCH2/MMP14/TMED2/INSIG1/EFNA1/GRHL2/CTNNB1/NCOA1/NAGLU/ZFP36L1/MBD2/MAPK3/MYO6/FBN2/MYCN/RDH10/TP53/SPINT1/ATF4/MBD3 42 GO:0001837 epithelial to mesenchymal transition 22/852 157/18722 2.61938200998847e-06 0.000129248526041882 ENG/FGFR1/NOG/SFRP1/TCF7L2/GATA3/SMAD3/WWTR1/ADAM15/TGFB1/TGFB2/FLNA/PHLDB2/EFNA1/TIAM1/CTNNB1/RTN4/DAG1/ZNF703/MDK/DDX17/TGFBR3 22 GO:0035966 response to topologically incorrect protein 22/852 159/18722 3.24054438375725e-06 0.000158346212460682 ABCA7/SERPINH1/XBP1/OS9/HSPB1/TMED2/WFS1/ATF3/CREB3L2/HERPUD1/PPP1R15B/ERO1A/TMBIM6/STT3B/AMFR/EDEM3/TRAM1/HSPH1/PIK3R1/ATF4/SDF2L1/DNAJC3 22 GO:0051896 regulation of protein kinase B signaling 24/852 185/18722 3.73213460757712e-06 0.000178563398193699 IGF2/HLA-G/ENG/FGFR1/ITGB1/TCF7L2/GATA3/GDF15/SEMA5A/RCN3/TGFB1/HIP1/INSR/MTDH/RTN4/DAG1/TPBG/PINK1/PLEKHA1/TXN/PTK2/PIK3CB/P2RX4/MYDGF 24 GO:0071560 cellular response to transforming growth factor beta stimulus 29/852 250/18722 3.76290764026598e-06 0.000178563398193699 HTRA1/HPGD/HTRA4/COL4A2/LTBP1/ENG/FBN1/SFRP1/CITED2/GDF15/ACVRL1/PXN/SMAD3/TGFB1/TGFB2/CDKN1C/LTBP3/ADAM9/DNM2/CAV2/ZFP36L1/PTK2/FBN2/FURIN/TP53/ZNF703/ID1/ADAM17/TGFBR3 29 GO:0001892 embryonic placenta development 15/852 82/18722 3.7805639577542e-06 0.000178563398193699 IGF2/EPAS1/ASCL2/ADM/CITED2/KRT19/GCM1/GATA2/PLCD3/KRT8/TMED2/GRHL2/NCOA1/ZFP36L1/SPINT1 15 GO:1990778 protein localization to cell periphery 35/852 333/18722 3.79620178953423e-06 0.000178563398193699 ITGB1/F11R/TGFB1/GPC4/ARHGEF16/EPHB2/MYADM/TMEM59/FLNA/PKP2/ACTB/MMP14/SEC23A/TMED2/RAB8B/ADAM10/PICALM/TSPAN14/DAG1/TPBG/LAMA5/LRP1/LGALS3/SEC16A/BSG/EZR/JUP/LYPLA1/PIK3R1/GOLPH3/KRT18/PKP3/GORASP2/ACSL3/MACF1 35 GO:0061564 axon development 44/852 467/18722 4.23630465369236e-06 0.000195864486065554 FN1/PTPRF/NOG/ITGB1/PTN/GATA3/TSPO/SEMA5A/PLXNB2/ERBB2/CRABP2/METRN/PTPRS/EFNB1/APOE/EPHB2/FLNA/GRN/SEMA4C/NOTCH2/LAMB2/ACTB/PALLD/EFNA1/VASP/BMPR2/TIAM1/DNM2/PICALM/RTN4/EIF4G2/DAG1/LAMA5/C12orf57/PTK2/LRP1/SEMA7A/TRIO/CTTN/B4GALT5/BSG/NPTN/VCL/MACF1 44 GO:0010001 glial cell differentiation 27/852 225/18722 4.2646361522588e-06 0.000195864486065554 SERPINE2/IL6ST/NOG/PTN/CD9/GCM1/ERBB2/METRN/TGFB1/SOX4/GRN/LAMB2/CTNNB1/GBA/DAG1/LDLR/NDRG1/ERBB3/LRP1/GPC1/MAPK3/MYCN/B4GALT5/MDK/RHEB/NCSTN/SPINT1 27 GO:0006457 protein folding 26/852 212/18722 4.28076564021677e-06 0.000195864486065554 QSOX1/P4HB/FKBP11/PRDX4/GRN/P3H1/PPIC/PDIA5/HSPB1/WFS1/CANX/FKBP9/CALR/HSP90B1/LMAN1/PPIB/PDIA3/DNAJC10/ERO1A/MOGS/PDIA4/HSPH1/SDF2L1/DNAJC3/SIL1/ERP29 26 GO:0032963 collagen metabolic process 17/852 104/18722 4.35259193717396e-06 0.000197356713691861 ENG/ITGB1/MMP11/MMP2/PLOD3/RCN3/ADAM15/TGFB1/SERPINH1/P3H4/CTSL/P3H1/MMP14/CTSB/TRAM2/FURIN/ERRFI1 17 GO:0050767 regulation of neurogenesis 37/852 364/18722 4.41983565315113e-06 0.000198616364663479 FN1/SERPINE2/IL6ST/ASCL2/NOG/PTN/TSPO/SEMA5A/PLXNB2/CRABP2/METRN/PTPRS/TGFB1/EPHB2/SEMA4C/MAN2A1/BMPR2/TIAM1/CTNNB1/RTN4/EIF4G2/DAG1/LDLR/LRP1/SEMA7A/MYCN/CTDSP1/PPP3CA/NPTN/TP53/MDK/RHEB/ID1/SPINT1/CUX1/OBSL1/MACF1 37 GO:0048771 tissue remodeling 23/852 175/18722 4.74082322664648e-06 0.000211155427431077 BGN/EPAS1/SFRP1/PTN/TIMP1/MMP2/ACVRL1/TGFB1/PTK2B/P3H4/FLNA/NOTCH2/CSF1R/MMP14/LTBP3/TNFAIP3/BMPR2/CTNNB1/UBASH3B/PPP3CA/TP53/MDK/ATP6AP1 23 GO:0048844 artery morphogenesis 14/852 74/18722 5.25277014265626e-06 0.000231638234349663 HPGD/ENG/NOG/FKBP10/CITED2/ACVRL1/TGFB2/APOE/SOX4/BMPR2/GJA5/LDLR/LRP1/MDK 14 GO:0001952 regulation of cell-matrix adhesion 19/852 128/18722 5.29274725813854e-06 0.000231638234349663 SERPINE1/SFRP1/SDC4/ACVRL1/SMAD3/ADAM15/LIMCH1/PTK2B/PHLDB2/MMP14/DAG1/PTK2/LRP1/PIK3CB/IQGAP1/VCL/JUP/PIK3R1/MACF1 19 GO:0071692 protein localization to extracellular region 37/852 368/18722 5.68599606205336e-06 0.000246703605002712 LTBP1/FBN1/SFRP1/TCF7L2/HMGN3/PAM/RCN3/CAMK2N1/TGFB1/TGFB2/APOE/SOX4/P3H1/STXBP5/RAB8B/CANX/ABCA1/TIAM1/ADAM9/TMED10/ACSL4/LRP1/FBN2/TVP23B/SEL1L/COPG1/PPP3CA/EZR/PDIA4/ARFGAP3/GOLPH3/TMEM167A/SLC16A1/SRI/DPP4/ERP29/FRMD4A 37 GO:0071772 response to BMP 22/852 165/18722 5.99300909850739e-06 0.00025362418080277 FSTL3/HTRA1/FSTL1/ENG/FBN1/NOG/SFRP1/GATA3/GDF15/ACVRL1/SMAD3/TGFB1/TGFB2/PCSK6/NOTCH2/CRIM1/BMPR2/EGR1/MAPK3/XIAP/SPINT1/TGFBR3 22 GO:0071773 cellular response to BMP stimulus 22/852 165/18722 5.99300909850739e-06 0.00025362418080277 FSTL3/HTRA1/FSTL1/ENG/FBN1/NOG/SFRP1/GATA3/GDF15/ACVRL1/SMAD3/TGFB1/TGFB2/PCSK6/NOTCH2/CRIM1/BMPR2/EGR1/MAPK3/XIAP/SPINT1/TGFBR3 22 GO:0071559 response to transforming growth factor beta 29/852 256/18722 6.01586191560953e-06 0.00025362418080277 HTRA1/HPGD/HTRA4/COL4A2/LTBP1/ENG/FBN1/SFRP1/CITED2/GDF15/ACVRL1/PXN/SMAD3/TGFB1/TGFB2/CDKN1C/LTBP3/ADAM9/DNM2/CAV2/ZFP36L1/PTK2/FBN2/FURIN/TP53/ZNF703/ID1/ADAM17/TGFBR3 29 GO:0060541 respiratory system development 25/852 203/18722 6.04706967938255e-06 0.00025362418080277 FSTL3/SPARC/EPAS1/NOG/PTN/PLOD3/RCN3/CRISPLD2/MMP14/MAN2A1/EIF4EBP1/LTBP3/BMPR2/GRHL2/CTNNB1/DAG1/CTSZ/LAMA5/MAPK3/MYCN/MAN1A2/SRSF6/RDH10/CTSH/ERRFI1 25 GO:0042692 muscle cell differentiation 38/852 384/18722 6.1838104550656e-06 0.000257215851407811 IGF2/TPM1/ADAM12/ENG/ITGB1/ADM/KRT19/CD9/GDF15/JAM2/PDLIM5/TGFB1/ATP11A/KRT8/SMYD3/EDNRB/XBP1/SEMA4C/SYNE1/MORF4L2/MMP14/PLD3/CALR/BMPR2/FHL2/SDC1/CTNNB1/HDAC5/MYH9/RCAN1/CAV2/CAPN2/ACTN4/PPP3CA/KLF5/CSRP1/ACTN1/OBSL1 38 GO:0016358 dendrite development 28/852 243/18722 6.26195999583456e-06 0.00025833151359865 ITGB1/PTN/PDLIM5/IQSEC1/PTPRS/APOE/MFSD2A/EPHB2/SRGAP2C/EFNA1/SRGAP2/PLK2/ADAM10/TIAM1/CARM1/PICALM/MAPK6/EIF4G2/TPBG/ACSL4/ARF4/IQGAP1/RBFOX2/PPP3CA/ID1/CUX1/FMR1/OBSL1 28 GO:0006613 cotranslational protein targeting to membrane 9/852 31/18722 6.54543433622667e-06 0.000264503728792085 SEC61A1/SSR3/SEC62/TRAM2/SSR1/TRAM1/SEC63/SSR2/SIL1 9 GO:0071711 basement membrane organization 9/852 31/18722 6.54543433622667e-06 0.000264503728792085 COL4A1/ITGB1/MMP11/PLOD3/NTN4/LAMB2/PHLDB2/DAG1/CAV2 9 GO:0042326 negative regulation of phosphorylation 38/852 385/18722 6.56923626048294e-06 0.000264503728792085 IGFBP3/ENG/NOG/SFRP1/FBLN1/SH3BP5/PRKAG2/WWTR1/CAMK2N1/TGFB1/GPRC5A/APOE/INHA/EPHB2/MYADM/CDKN1C/SMYD3/PLPP3/HSPB1/TMED2/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/LRP1/PIK3CB/CTDSP1/PRKAR2A/HIPK3/DNAJC10/PPP1R15B/GNAQ/ERRFI1/IPO7/DNAJC3 38 GO:0006898 receptor-mediated endocytosis 28/852 244/18722 6.77425264378046e-06 0.00027059375838212 SERPINE1/HSPG2/ITGB1/ADM/CD9/APOC1/APOE/HIP1/CTSL/CD63/ANKRD13A/INSR/CLTB/CANX/SCARB2/DNM2/PICALM/LDLR/CAV2/LMBRD1/LRP1/PIK3CB/IGF2R/CTTN/GPR107/AP1G1/EZR/FMR1 28 GO:0051043 regulation of membrane protein ectodomain proteolysis 8/852 24/18722 6.82912974318792e-06 0.000270637873995786 TIMP3/TIMP2/TIMP1/APOE/ADAM9/SH3D19/FURIN/PTPN3 8 GO:0045862 positive regulation of proteolysis 37/852 372/18722 7.27963763448717e-06 0.000286237626674796 FN1/TNFSF10/EGLN3/FBLN1/RCN3/SMAD3/PTK2B/APOE/HIP1/GRN/RPS27L/MMP14/EFNA1/PLK2/PRSS22/ADAM9/DAP/GBA/PICALM/MYH9/DAPK1/PINK1/SH3D19/ANKIB1/PTK2/TBC1D10A/NLRP2/HERPUD1/RNF144B/RNF139/FURIN/CSNK1A1/CTSH/NCSTN/GSN/FMR1/TMEM259 37 GO:0010594 regulation of endothelial cell migration 27/852 232/18722 7.58394893427929e-06 0.000295891589040525 SPARC/FGFR1/PTN/GATA3/PRCP/ACVRL1/SEMA5A/GATA2/TGFB1/PTK2B/APOE/SCARB1/GRN/PLPP3/HSPB1/EFNA1/PLK2/SASH1/CALR/BMPR2/HDAC5/PTK2/PIK3CB/P2RX4/JUP/ADAM17/EMC10 27 GO:1900024 regulation of substrate adhesion-dependent cell spreading 12/852 57/18722 7.78885060183305e-06 0.000301548346761737 FBLN1/DOCK5/P4HB/MYADM/FLNA/CALR/DNM2/PTK2/ACTN4/ARHGEF7/MDK/RREB1 12 GO:0007029 endoplasmic reticulum organization 15/852 87/18722 8.07721682523373e-06 0.000310325437262606 ATL3/TMED2/TOR1AIP2/SEC31A/LMAN1/RTN4/SEC61A1/CAV2/SEC16A/TRAM2/REEP3/TRAM1/LMAN2/EMC10/REEP5 15 GO:0070527 platelet aggregation 13/852 67/18722 8.49421527833688e-06 0.000323874132544466 FN1/SERPINE2/IL6ST/CD9/F11R/FLNA/ACTB/HSPB1/MYH9/UBASH3B/PIK3CB/VCL/CSRP1 13 GO:0003206 cardiac chamber morphogenesis 18/852 121/18722 9.02067786385627e-06 0.000341361441269087 TPM1/ENG/NOG/CITED2/GATA3/ADAMTS1/TGFB1/TGFB2/SOX4/PARVA/PKP2/NOTCH2/BMPR2/GRHL2/FHL2/DHRS3/TP53/TGFBR3 18 GO:0007030 Golgi organization 21/852 157/18722 9.22211884436712e-06 0.000346380030923132 ATL3/SYNE1/TMED2/LMAN1/DNM2/TMED3/TMED10/SURF4/TMED7/SEC16A/MAPK3/TMED9/USO1/CSNK1A1/ARHGEF7/SEC22B/YIPF5/GOLPH3/LMAN2/GORASP2/OBSL1 21 GO:0010595 positive regulation of endothelial cell migration 19/852 133/18722 9.35571408289654e-06 0.000348794881327543 SPARC/FGFR1/GATA3/SEMA5A/GATA2/TGFB1/PTK2B/SCARB1/GRN/PLPP3/HSPB1/PLK2/SASH1/CALR/BMPR2/PIK3CB/P2RX4/ADAM17/EMC10 19 GO:0010717 regulation of epithelial to mesenchymal transition 16/852 99/18722 9.61411351514676e-06 0.000353195863662289 ENG/NOG/SFRP1/TCF7L2/GATA3/SMAD3/WWTR1/TGFB1/TGFB2/PHLDB2/EFNA1/TIAM1/CTNNB1/DAG1/ZNF703/MDK 16 GO:0060996 dendritic spine development 16/852 99/18722 9.61411351514676e-06 0.000353195863662289 PDLIM5/IQSEC1/PTPRS/APOE/EPHB2/SRGAP2C/EFNA1/SRGAP2/PLK2/ADAM10/TIAM1/MAPK6/EIF4G2/ACSL4/ARF4/FMR1 16 GO:0001503 ossification 39/852 408/18722 1.05819729925544e-05 0.000385935290373379 NOTUM/FSTL3/IGF2/SPARC/IL6ST/NOG/SFRP1/PTN/MMP2/SMAD3/WWTR1/TGFB1/TGFB2/PTK2B/COL6A1/ID3/SGMS2/CCR1/BMP1/CRIM1/MMP14/ISG15/LTBP3/BMPR2/FHL2/DHRS3/CTNNB1/RRBP1/PTK2/SEMA7A/BCAP29/MAPK3/FBN2/KLF10/INPPL1/MDK/EXT2/ATF4/ATP6AP1 39 GO:0050920 regulation of chemotaxis 26/852 223/18722 1.07666097500419e-05 0.000389844222100438 SERPINE1/FGFR1/PTN/SEMA5A/PLA2G7/SMAD3/TGFB1/PTK2B/CCR1/SEMA4C/PGF/CSF1R/HSPB1/CALR/ADAM10/BMPR2/TIAM1/TPBG/PTK2/MIF/SEMA7A/MAPK3/P2RX4/MDK/ADAM17/DPP4 26 GO:0010811 positive regulation of cell-substrate adhesion 18/852 123/18722 1.13816518211608e-05 0.000409170382970733 FN1/SFRP1/PTN/DOCK5/P4HB/SDC4/SMAD3/PTK2B/MYADM/FLNA/CALR/DNM2/DAG1/IQGAP1/ARHGEF7/MDK/JUP/RREB1 18 GO:0043491 protein kinase B signaling 25/852 211/18722 1.19614605609892e-05 0.000426964758889779 IGF2/HLA-G/ENG/FGFR1/ITGB1/TCF7L2/GATA3/GDF15/SEMA5A/RCN3/TGFB1/HIP1/INSR/MTDH/RTN4/DAG1/TPBG/PINK1/PLEKHA1/TXN/ZFP36L1/PTK2/PIK3CB/P2RX4/MYDGF 25 GO:0006491 N-glycan processing 7/852 19/18722 1.22844855786922e-05 0.000435407154349 MGAT4A/MAN2A1/PRKCSH/MAN1B1/MGAT4B/MAN1A2/GANAB 7 GO:0016485 protein processing 26/852 225/18722 1.26328204244112e-05 0.000441534619417095 SERPINE2/SERPINE1/ADAM19/IL1R2/PCSK1N/TMEM59/CPM/CTSL/PCSK6/MMP14/ADAM10/MYH9/HM13/CLN5/CTSZ/TBC1D10A/RNF139/CAPN2/FURIN/CTSH/XIAP/DDI2/NCSTN/GSN/SPCS3/ADAM17 26 GO:0050769 positive regulation of neurogenesis 26/852 225/18722 1.26328204244112e-05 0.000441534619417095 FN1/SERPINE2/IL6ST/PTN/TSPO/SEMA5A/PLXNB2/CRABP2/METRN/TGFB1/EPHB2/MAN2A1/BMPR2/TIAM1/CTNNB1/EIF4G2/DAG1/LRP1/SEMA7A/NPTN/MDK/RHEB/SPINT1/CUX1/OBSL1/MACF1 26 GO:0051271 negative regulation of cellular component movement 36/852 367/18722 1.30927369537633e-05 0.000454453414402005 TPM1/SERPINE1/IGFBP3/ENG/NOG/SFRP1/FBLN1/CITED2/PTN/GATA3/TIMP1/CD9/CLDN19/ACVRL1/ARHGDIB/ADAM15/TGFB1/LIMCH1/APOE/PHLDB2/SRGAP2C/CNN2/CLIC4/SRGAP2/CALR/HDAC5/DAG1/BST2/LRP1/EVL/MIF/VCL/JUP/ACTN1/TGFBR3/DPP4 36 GO:1902903 regulation of supramolecular fiber organization 37/852 382/18722 1.32282335363491e-05 0.000456011639646883 TPM1/SFRP1/F11R/COTL1/SDC4/SEMA5A/ASAP3/PXN/TMSB10/SMAD3/CAPG/LIMCH1/PTK2B/ESAM/APOE/BAIAP2L1/CDC42EP5/MYADM/FLNA/LIMA1/PHLDB2/COLGALT1/VASP/ARHGEF2/NCKAP1/CDC42EP1/LDLR/DSTN/EVL/CTTN/SSH2/ARHGEF7/ID1/PIK3R1/GSN/MYO1C/RHOC 37 GO:0060669 embryonic placenta morphogenesis 8/852 26/18722 1.33758198433703e-05 0.000457962593684916 IGF2/ADM/GCM1/TMED2/GRHL2/NCOA1/ZFP36L1/SPINT1 8 GO:1905475 regulation of protein localization to membrane 22/852 175/18722 1.55296907252455e-05 0.000528114415001084 ITGB1/PTN/ERBB2/TGFB1/GPC4/ARHGEF16/EPHB2/TMEM59/ACTB/MMP14/ADAM10/PICALM/DAG1/LRP1/LGALS3/GPC1/EZR/LYPLA1/PIK3R1/GSN/MYO1C/ACSL3 22 GO:0006900 vesicle budding from membrane 12/852 61/18722 1.62280297151006e-05 0.000548158882926853 SEC24D/SEC23A/TMED2/INSIG1/SEC24A/SEC31A/PICALM/TMED10/SAR1A/TMED9/ARFGAP3/GOLPH3 12 GO:0030902 hindbrain development 20/852 151/18722 1.73271151956958e-05 0.000581382471866246 SERPINE2/NOG/ITGB1/PTN/GATA2/PTPRS/FLNA/HERC1/SEMA4C/CTNNB1/GBA/SDF4/NCOA1/NAGLU/ATRN/RBFOX2/TP53/ARCN1/MDK/NCSTN 20 GO:0007409 axonogenesis 39/852 418/18722 1.84548251700921e-05 0.000615120099874659 FN1/NOG/ITGB1/GATA3/SEMA5A/PLXNB2/ERBB2/CRABP2/METRN/PTPRS/EFNB1/APOE/EPHB2/SEMA4C/NOTCH2/LAMB2/ACTB/PALLD/EFNA1/VASP/BMPR2/TIAM1/DNM2/PICALM/RTN4/EIF4G2/DAG1/LAMA5/C12orf57/PTK2/LRP1/SEMA7A/TRIO/CTTN/B4GALT5/BSG/NPTN/VCL/MACF1 39 GO:0030509 BMP signaling pathway 20/852 152/18722 1.91161604287815e-05 0.000629515003846947 FSTL3/HTRA1/FSTL1/ENG/FBN1/NOG/SFRP1/GDF15/ACVRL1/SMAD3/TGFB1/TGFB2/PCSK6/NOTCH2/CRIM1/BMPR2/EGR1/MAPK3/XIAP/TGFBR3 20 GO:0035437 maintenance of protein localization in endoplasmic reticulum 6/852 14/18722 1.91368558689813e-05 0.000629515003846947 KDELR3/OS9/INSIG1/KDELR2/KDELR1/GPAA1 6 GO:0007596 blood coagulation 25/852 217/18722 1.94258537180553e-05 0.00063487221924008 FN1/SERPINE2/SERPINE1/IL6ST/SERPING1/TFPI/FBLN1/CD9/F11R/PROCR/APOE/EPHB2/FLNA/ACTB/CD59/HSPB1/LMAN1/MYH9/UBASH3B/DGKZ/PIK3CB/VKORC1/GNAQ/VCL/CSRP1 25 GO:0048732 gland development 40/852 436/18722 2.13516019454584e-05 0.000693307178009626 SERPINE2/FSTL3/IGF2/NOG/SFRP1/CITED2/PTN/GATA3/TSPO/PAM/PSAP/GATA2/SMAD3/TGFB1/TGFB2/NTN4/XBP1/NOTCH2/IGSF3/CSF1R/MAN2A1/NCOR2/TNFAIP3/CTNNB1/PRKCSH/RTN4/NCOA1/DAG1/LAMA5/IGF2R/MAPK3/LSR/ZNF703/BTBD7/MDK/PTPN3/RREB1/KRT18/SEC63/TGFBR3 40 GO:0007162 negative regulation of cell adhesion 31/852 303/18722 2.28430815702312e-05 0.000736982240660087 SERPINE2/SERPINE1/HLA-G/FBLN1/CD9/SDC4/ACVRL1/SEMA5A/PLXNB2/ERBB2/ARHGDIB/FXYD5/ADAM15/TGFB1/EPHB2/MYADM/PHLDB2/MMP14/ADAM10/CBLB/UBASH3B/PTK2/ERBB3/LRP1/LGALS3/CD164/ACTN4/ZNF703/NDFIP1/MDK/PIK3R1 31 GO:0002064 epithelial cell development 25/852 220/18722 2.45562901552931e-05 0.000787208970392295 IL6ST/FLNB/SLC4A7/F11R/PLOD3/PTPRS/MYADM/FLNA/B4GALT1/NOTCH2/LAMB2/FOSL2/PALLD/CLIC4/FAT1/GRHL2/SDC1/IQGAP1/KLF5/EZR/TJP2/VCL/RHEB/ATF4/YIPF6 25 GO:0030968 endoplasmic reticulum unfolded protein response 13/852 74/18722 2.61106119422232e-05 0.000825902322220496 ABCA7/XBP1/OS9/TMED2/WFS1/ATF3/CREB3L2/HERPUD1/PPP1R15B/ERO1A/AMFR/PIK3R1/ATF4 13 GO:0150105 protein localization to cell-cell junction 7/852 21/18722 2.61701468199798e-05 0.000825902322220496 F11R/FLNA/ACTB/JAK1/LSR/TJP2/VCL 7 GO:0031532 actin cytoskeleton reorganization 16/852 107/18722 2.62555874339915e-05 0.000825902322220496 F11R/CLDN19/ARHGDIB/SYDE1/PTK2B/ESAM/BAIAP2L1/FLNA/PARVA/NOTCH2/CSF1R/MYH9/CTTN/EZR/MDK/GSN 16 GO:0085029 extracellular matrix assembly 10/852 45/18722 2.70080062120828e-05 0.000844293759412503 QSOX1/FKBP10/PLOD3/SMAD3/TGFB1/NTN4/LAMB2/PHLDB2/LTBP3/DAG1 10 GO:0010769 regulation of cell morphogenesis involved in differentiation 15/852 96/18722 2.74254893542612e-05 0.000852052394567879 FBLN1/DOCK5/P4HB/MYADM/FLNA/CALR/TIAM1/DNM2/PTK2/ACTN4/ARHGEF7/MDK/RREB1/CUX1/OBSL1 15 GO:0007599 hemostasis 25/852 222/18722 2.86261084830527e-05 0.000878400064195224 FN1/SERPINE2/SERPINE1/IL6ST/SERPING1/TFPI/FBLN1/CD9/F11R/PROCR/APOE/EPHB2/FLNA/ACTB/CD59/HSPB1/LMAN1/MYH9/UBASH3B/DGKZ/PIK3CB/VKORC1/GNAQ/VCL/CSRP1 25 GO:0050817 coagulation 25/852 222/18722 2.86261084830527e-05 0.000878400064195224 FN1/SERPINE2/SERPINE1/IL6ST/SERPING1/TFPI/FBLN1/CD9/F11R/PROCR/APOE/EPHB2/FLNA/ACTB/CD59/HSPB1/LMAN1/MYH9/UBASH3B/DGKZ/PIK3CB/VKORC1/GNAQ/VCL/CSRP1 25 GO:0061138 morphogenesis of a branching epithelium 22/852 182/18722 2.87971409879221e-05 0.000878400064195224 COL4A1/ENG/NOG/SFRP1/ADM/GCM1/NTN4/MMP14/TMED2/CLIC4/GRHL2/CTNNB1/DAG1/CTSZ/LAMA5/MAGED1/MYCN/RDH10/CTSH/BTBD7/MDK/SPINT1 22 GO:0090110 COPII-coated vesicle cargo loading 6/852 15/18722 3.06670796016393e-05 0.000922277406280306 SEC24D/SEC23A/INSIG1/SEC24A/SEC31A/SAR1A 6 GO:0051960 regulation of nervous system development 40/852 443/18722 3.06961705182687e-05 0.000922277406280306 FN1/SERPINE2/IL6ST/ASCL2/NOG/IL1RAP/PTN/JAM2/TSPO/SEMA5A/PLXNB2/CRABP2/METRN/PTPRS/TGFB1/EPHB2/SEMA4C/MAN2A1/BMPR2/TIAM1/CTNNB1/RTN4/EIF4G2/DAG1/TPBG/LDLR/LRP1/SEMA7A/MYCN/CTDSP1/PPP3CA/NPTN/TP53/MDK/RHEB/ID1/SPINT1/CUX1/OBSL1/MACF1 40 GO:0001763 morphogenesis of a branching structure 23/852 196/18722 3.08158743752528e-05 0.000922277406280306 COL4A1/ENG/NOG/SFRP1/ADM/GCM1/NTN4/MMP14/TMED2/CLIC4/GRHL2/CTNNB1/RTN4/DAG1/CTSZ/LAMA5/MAGED1/MYCN/RDH10/CTSH/BTBD7/MDK/SPINT1 23 GO:1905517 macrophage migration 11/852 55/18722 3.09685836799864e-05 0.000922277406280306 CD9/PTK2B/EDNRB/CSF1R/MMP14/PTK2/LGALS3/MIF/MAPK3/P2RX4/MDK 11 GO:0090114 COPII-coated vesicle budding 8/852 29/18722 3.25428397128345e-05 0.000963459483968801 SEC24D/SEC23A/TMED2/INSIG1/SEC24A/SEC31A/TMED10/SAR1A 8 GO:0031346 positive regulation of cell projection organization 34/852 353/18722 3.29020883281705e-05 0.000968398892138492 FN1/PTN/SEMA5A/PLXNB2/CRABP2/METRN/PTK2B/APOE/CDC42EP5/FLNA/GRN/P3H1/RAB8B/NCKAP1/BMPR2/CREB3L2/SCARB2/TIAM1/DNM2/EIF4G2/CDC42EP1/LRP1/SEMA7A/IQGAP1/NPTN/ARHGEF7/MDK/PIK3R1/RREB1/CUX1/FMR1/EPS8L2/OBSL1/MACF1 34 GO:0071827 plasma lipoprotein particle organization 10/852 46/18722 3.31156536827934e-05 0.000969017935962205 APOC1/PLA2G7/LPL/ABCA7/APOE/MFSD2A/SCARB1/ABCA1/LIPG/ACSL3 10 GO:0043434 response to peptide hormone 38/852 414/18722 3.37459083587214e-05 0.000981752351268466 IGF2/TNFSF10/SPARC/FBN1/ADM/TIMP1/GDF15/POMC/PXN/LPL/CSH1/BAIAP2L1/EDNRB/XBP1/INSIG1/CYP11A1/RAB8B/INSR/EIF4EBP2/AP3S1/HDAC5/STAT2/DAG1/CAV2/ZFP36L1/EGR1/PTK2/YWHAG/IQGAP1/BCAR3/BSG/USO1/SRSF6/INPPL1/PIK3R1/ERRFI1/MYO1C/TGFBR3 38 GO:0010975 regulation of neuron projection development 40/852 445/18722 3.39822142807482e-05 0.000982945313074744 FN1/PTPRF/SFRP1/PTN/GATA3/PDLIM5/SEMA5A/PLXNB2/CRABP2/METRN/PTPRS/PTK2B/APOE/MFSD2A/EPHB2/FLNA/GRN/P3H1/SEMA4C/EFNA1/ADAM10/BMPR2/CREB3L2/SCARB2/TIAM1/CARM1/RTN4/EIF4G2/CTSZ/LRP1/SEMA7A/IQGAP1/PPP3CA/NPTN/ITM2C/MDK/ID1/CUX1/OBSL1/MACF1 40 GO:0060326 cell chemotaxis 31/852 310/18722 3.55447149107494e-05 0.00102226600083315 FLT1/SERPINE1/FGFR1/PTN/SEMA5A/ITGA1/PLA2G7/TGFB2/PTK2B/ARHGEF16/CCR1/PARVA/EDNRB/PGF/CSF1R/HSPB1/CALR/ADAM10/TIAM1/PPIB/TPBG/PTK2/LGALS3/MIF/MAPK3/ACKR2/BSG/P2RX4/MDK/ADAM17/DPP4 31 GO:0060562 epithelial tube morphogenesis 32/852 325/18722 3.62744408040595e-05 0.0010353197059797 COL4A1/ENG/NOG/SFRP1/ADM/CITED2/GATA3/SDC4/ACVRL1/PLXNB2/SMAD3/TGFB1/TGFB2/SOX4/SEMA4C/NOTCH2/CSF1R/MMP14/TMED2/CLIC4/VASP/GRHL2/CTNNB1/DAG1/CTSZ/LAMA5/MAGED1/MYCN/RDH10/CTSH/MDK/SPINT1 32 GO:0060713 labyrinthine layer morphogenesis 7/852 22/18722 3.68800179690746e-05 0.0010353197059797 ADM/GCM1/TMED2/GRHL2/NCOA1/ZFP36L1/SPINT1 7 GO:0030166 proteoglycan biosynthetic process 11/852 56/18722 3.69713052650113e-05 0.0010353197059797 TCF7L2/CHPF/EXTL3/UGDH/DSEL/HS6ST1/BMPR2/CTNNB1/CHPF2/DSE/EXT2 11 GO:0051893 regulation of focal adhesion assembly 12/852 66/18722 3.72134196955936e-05 0.0010353197059797 SFRP1/SDC4/ACVRL1/SMAD3/LIMCH1/PHLDB2/MMP14/PTK2/LRP1/IQGAP1/VCL/MACF1 12 GO:0090109 regulation of cell-substrate junction assembly 12/852 66/18722 3.72134196955936e-05 0.0010353197059797 SFRP1/SDC4/ACVRL1/SMAD3/LIMCH1/PHLDB2/MMP14/PTK2/LRP1/IQGAP1/VCL/MACF1 12 GO:0061041 regulation of wound healing 18/852 134/18722 3.72328366346763e-05 0.0010353197059797 SERPINE2/SERPINE1/SERPING1/TFPI/ITGB1/CD9/CLDN19/SMAD3/APOE/EPHB2/XBP1/PHLDB2/PLPP3/TNFAIP3/UBASH3B/PTK2/SRSF6/RREB1 18 GO:0006469 negative regulation of protein kinase activity 24/852 212/18722 3.77170627911521e-05 0.00104302185180147 SFRP1/SH3BP5/PRKAG2/WWTR1/CAMK2N1/GPRC5A/APOE/EPHB2/CDKN1C/SMYD3/HSPB1/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/PIK3CB/PRKAR2A/HIPK3/GNAQ/ERRFI1/IPO7 24 GO:0002934 desmosome organization 5/852 10/18722 4.0149053956671e-05 0.00109744140546252 PKP2/DSG2/JUP/PKP3/GRHL1 5 GO:0048194 Golgi vesicle budding 5/852 10/18722 4.0149053956671e-05 0.00109744140546252 TMED2/TMED10/TMED9/ARFGAP3/GOLPH3 5 GO:0051146 striated muscle cell differentiation 29/852 283/18722 4.03390939818331e-05 0.00109744140546252 IGF2/TPM1/ADAM12/ITGB1/KRT19/CD9/GDF15/JAM2/PDLIM5/TGFB1/ATP11A/KRT8/SMYD3/XBP1/MORF4L2/MMP14/PLD3/CALR/FHL2/SDC1/HDAC5/MYH9/RCAN1/CAV2/CAPN2/PPP3CA/KLF5/CSRP1/OBSL1 29 GO:0051651 maintenance of location in cell 24/852 213/18722 4.07167567200229e-05 0.00110176041167675 TSPO/KDELR3/TMSB10/SLC30A2/PTK2B/APOE/GAA/OS9/SYNE1/INSIG1/CALR/HSP90B1/KDELR2/UBASH3B/PINK1/TXN/KDELR1/SUN2/ITPR2/ERO1A/GSN/GOLPH3/SRI/GPAA1 24 GO:0002687 positive regulation of leukocyte migration 18/852 135/18722 4.11691354441292e-05 0.00110804416411926 SERPINE1/IL1R1/PTN/JAM2/PLA2G7/PTK2B/CCR1/PGF/CSF1R/MMP14/CALR/ADAM10/PTK2/LGALS3/MAPK3/P2RX4/MDK/ADAM17 18 GO:0031647 regulation of protein stability 30/852 298/18722 4.17220330840907e-05 0.001116952087831 SMAD3/HIP1/SOX4/FLNA/PARVA/GRN/P3H1/PLPP3/EFNA1/CTSA/WFS1/CALR/PPIB/RTN4/LAMP1/PINK1/SERF2/SEC16A/RNF139/B4GALT5/SEL1L/CTSH/TP53/GNAQ/DDI2/DDOST/PIK3R1/GSN/LAMP2/SH3GLB1 30 GO:0009306 protein secretion 34/852 359/18722 4.62866712312952e-05 0.00123259691167782 SFRP1/TCF7L2/HMGN3/PAM/RCN3/CAMK2N1/TGFB1/TGFB2/APOE/SOX4/P3H1/STXBP5/RAB8B/CANX/ABCA1/TIAM1/ADAM9/TMED10/ACSL4/LRP1/TVP23B/SEL1L/COPG1/PPP3CA/EZR/PDIA4/ARFGAP3/GOLPH3/TMEM167A/SLC16A1/SRI/DPP4/ERP29/FRMD4A 34 GO:0035592 establishment of protein localization to extracellular region 34/852 360/18722 4.89461195514888e-05 0.00129655694580338 SFRP1/TCF7L2/HMGN3/PAM/RCN3/CAMK2N1/TGFB1/TGFB2/APOE/SOX4/P3H1/STXBP5/RAB8B/CANX/ABCA1/TIAM1/ADAM9/TMED10/ACSL4/LRP1/TVP23B/SEL1L/COPG1/PPP3CA/EZR/PDIA4/ARFGAP3/GOLPH3/TMEM167A/SLC16A1/SRI/DPP4/ERP29/FRMD4A 34 GO:0007266 Rho protein signal transduction 18/852 137/18722 5.01656766136986e-05 0.00131206640003007 ITGB1/F11R/ARHGDIB/RASGRF2/APOE/CDC42EP5/RALBP1/RHOU/ABCA1/ARHGEF2/RHOD/CDC42SE1/CDC42EP1/ARHGAP1/CDC42SE2/MYO9B/ARHGAP29/EPS8L2 18 GO:0051962 positive regulation of nervous system development 28/852 272/18722 5.02348123046391e-05 0.00131206640003007 FN1/SERPINE2/IL6ST/IL1RAP/PTN/TSPO/SEMA5A/PLXNB2/CRABP2/METRN/TGFB1/EPHB2/MAN2A1/BMPR2/TIAM1/CTNNB1/EIF4G2/DAG1/TPBG/LRP1/SEMA7A/NPTN/MDK/RHEB/SPINT1/CUX1/OBSL1/MACF1 28 GO:0040013 negative regulation of locomotion 36/852 391/18722 5.05743853776741e-05 0.00131206640003007 TPM1/SERPINE1/IGFBP3/ENG/NOG/SFRP1/FBLN1/CITED2/PTN/GATA3/TIMP1/CLDN19/ACVRL1/SEMA5A/ARHGDIB/ADAM15/TGFB1/LIMCH1/APOE/SEMA4C/PHLDB2/SRGAP2C/CNN2/CLIC4/SRGAP2/CALR/HDAC5/DAG1/BST2/LRP1/EVL/MIF/SEMA7A/VCL/JUP/DPP4 36 GO:0042176 regulation of protein catabolic process 36/852 391/18722 5.05743853776741e-05 0.00131206640003007 SERPINE2/TIMP3/TIMP2/TIMP1/SMAD3/LPCAT1/PTK2B/APOE/FLNA/EFNA1/TNFAIP3/CTSA/PLK2/ADAM9/CBLB/GBA/PINK1/SH3D19/LDLR/ANKIB1/PTK2/LRP1/HERPUD1/RNF144B/RNF139/FURIN/CSNK1A1/EZR/DDB1/NDFIP1/SEC22B/SGSM3/PTPN3/UBE2K/FMR1/TMEM259 36 GO:1904375 regulation of protein localization to cell periphery 17/852 125/18722 5.1796281548763e-05 0.00133687530787141 ITGB1/TGFB1/GPC4/ARHGEF16/EPHB2/TMEM59/ACTB/MMP14/ADAM10/PICALM/DAG1/LRP1/LGALS3/EZR/LYPLA1/PIK3R1/ACSL3 17 GO:0006029 proteoglycan metabolic process 13/852 79/18722 5.33889552173013e-05 0.00137095210004427 BGN/TCF7L2/CHPF/EXTL3/UGDH/DSEL/HS6ST1/BMPR2/CTNNB1/CHPF2/GPC1/DSE/EXT2 13 GO:0030201 heparan sulfate proteoglycan metabolic process 8/852 31/18722 5.5163244755892e-05 0.00140220510533538 TCF7L2/EXTL3/UGDH/HS6ST1/CTNNB1/GPC1/DSE/EXT2 8 GO:0060055 angiogenesis involved in wound healing 8/852 31/18722 5.5163244755892e-05 0.00140220510533538 SERPINE1/MCAM/PRCP/GATA2/XBP1/B4GALT1/TNFAIP3/DAG1 8 GO:0045732 positive regulation of protein catabolic process 25/852 231/18722 5.5536044215003e-05 0.00140458749012116 LPCAT1/PTK2B/APOE/TNFAIP3/PLK2/ADAM9/CBLB/GBA/SH3D19/LDLR/ANKIB1/PTK2/LRP1/HERPUD1/RNF144B/RNF139/FURIN/CSNK1A1/EZR/DDB1/NDFIP1/SEC22B/SGSM3/FMR1/TMEM259 25 GO:0051098 regulation of binding 34/852 363/18722 5.77777418485749e-05 0.00145397687361939 PTPRF/NOG/TCF7L2/GATA3/PLCL2/SMAD3/ADAM15/TGFB1/APOE/ACTB/PLK2/TIAM1/CBLB/CTNNB1/HDAC5/CARM1/CTBP2/UBASH3B/TXN/CLN5/CTSZ/LRP1/MBD2/MAPK3/PPP3CA/CSNK1A1/ARHGEF7/TMBIM6/SYMPK/AMFR/ID1/FMR1/TGFBR3/SRI 34 GO:0060348 bone development 23/852 205/18722 6.25083421202468e-05 0.00156519644721991 NOTUM/PAPPA2/BGN/ENG/FBN1/CITED2/COL27A1/SH3PXD2B/SERPINH1/P3H1/NOTCH2/MMP14/INSIG1/LTBP3/BMPR2/DHRS3/SLC38A10/PPIB/VKORC1/INPPL1/TP53/EXT2/ATP6AP1 23 GO:0030048 actin filament-based movement 17/852 127/18722 6.3498055043969e-05 0.0015821074803777 TPM1/LIMCH1/KCNJ2/FLNA/PARVA/PKP2/DSG2/GJA5/MYH9/MYO6/ACTN4/SUN2/MYO9B/JUP/GSN/MYO1C/SRI 17 GO:0030278 regulation of ossification 16/852 115/18722 6.46249429739692e-05 0.00160225289649255 NOTUM/SFRP1/PTN/SMAD3/TGFB1/TGFB2/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/DHRS3/MAPK3/FBN2/MDK 16 GO:0060425 lung morphogenesis 10/852 50/18722 7.07691210330604e-05 0.00172903391339511 NOG/PLOD3/GRHL2/CTNNB1/DAG1/CTSZ/MAPK3/SRSF6/RDH10/CTSH 10 GO:0071825 protein-lipid complex subunit organization 10/852 50/18722 7.07691210330604e-05 0.00172903391339511 APOC1/PLA2G7/LPL/ABCA7/APOE/MFSD2A/SCARB1/ABCA1/LIPG/ACSL3 10 GO:1904036 negative regulation of epithelial cell apoptotic process 10/852 50/18722 7.07691210330604e-05 0.00172903391339511 SERPINE1/TCF7L2/GATA3/SEMA5A/GATA2/ANGPTL4/TNFAIP3/WFS1/SRSF6/MDK 10 GO:0007265 Ras protein signal transduction 32/852 337/18722 7.29608769583922e-05 0.0017707721799075 TIMP2/ITGB1/F11R/ARHGDIB/RASGRF2/IQSEC1/TGFB2/APOE/MAPRE2/CDC42EP5/EPHB2/RALBP1/RHOU/NOTCH2/PLK2/ABCA1/ARHGEF2/RHOD/NCKAP1/TIAM1/DNM2/CDC42SE1/CDC42EP1/PIK3CB/ARHGAP1/CDC42SE2/MYO9B/ARHGAP29/TP53/SGSM3/RREB1/EPS8L2 32 GO:0010721 negative regulation of cell development 21/852 180/18722 7.31811272443396e-05 0.0017707721799075 ASCL2/FBN1/NOG/FBLN1/PTN/TSPO/SEMA5A/PTPRS/EPHB2/EDNRB/SEMA4C/CTNNB1/RTN4/LDLR/SEMA7A/MYCN/ACTN4/CTDSP1/PPP3CA/TP53/ID1 21 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 9/852 41/18722 7.55468402644979e-05 0.00181060593833913 DOCK5/P4HB/MYADM/FLNA/CALR/DNM2/ARHGEF7/MDK/RREB1 9 GO:1905521 regulation of macrophage migration 9/852 41/18722 7.55468402644979e-05 0.00181060593833913 CD9/PTK2B/CSF1R/MMP14/PTK2/MIF/MAPK3/P2RX4/MDK 9 GO:0006022 aminoglycan metabolic process 17/852 129/18722 7.74710334542708e-05 0.00184792280272675 BGN/HEXB/CHPF/B3GNT7/UGDH/TGFB1/DSEL/HS6ST1/CHPF2/NAGLU/ST3GAL6/HEXA/B4GALT5/GNS/DSE/GLB1/EXT2 17 GO:0014902 myotube differentiation 16/852 117/18722 7.97892332737853e-05 0.00188801953409432 ADAM12/CD9/GDF15/JAM2/ATP11A/SMYD3/XBP1/MMP14/PLD3/HDAC5/MYH9/RCAN1/CAV2/CAPN2/PPP3CA/KLF5 16 GO:0050900 leukocyte migration 34/852 369/18722 7.99022771234034e-05 0.00188801953409432 FLT1/SERPINE1/IL1R1/ITGB1/PTN/GATA3/CD9/F11R/JAM2/ITGA1/PLA2G7/TGFB2/PTK2B/CCR1/EDNRB/B4GALT1/PGF/CSF1R/MMP14/CALR/ADAM10/GBA/PPIB/MYH9/PTK2/LGALS3/MIF/MAPK3/BSG/P2RX4/MDK/GOLPH3/ADAM17/DPP4 34 GO:0007568 aging 32/852 339/18722 8.1612835841577e-05 0.00191049954786352 SERPINE1/TIMP2/HLA-G/COL4A2/SERPING1/ADM/CITED2/TIMP1/TSPO/NUAK1/EDNRB/ENDOG/PLK2/CANX/CALR/RPN2/GBA/CARM1/PICALM/DAG1/YPEL3/LRP1/MIF/MBD2/MAPK3/GPX4/PPP3CA/TP53/ERO1A/AMFR/SEC63/MBD3 32 GO:0048545 response to steroid hormone 32/852 339/18722 8.1612835841577e-05 0.00191049954786352 PAPPA/SPARC/ENG/TFPI/SFRP1/ADM/PTN/HSD3B1/TSPO/PAM/TGFB1/TGFB2/SMYD3/FBXO32/NCOR2/PKN1/CALR/SDC1/ADAM9/GBA/CARM1/NCOA1/ZFP36L1/PAQR7/FOSB/PGRMC2/RBFOX2/RXRA/MDK/GLB1/ERRFI1/DDX17 32 GO:1902905 positive regulation of supramolecular fiber organization 23/852 209/18722 8.4228093023956e-05 0.0019625925564332 TPM1/SFRP1/SDC4/SEMA5A/PXN/SMAD3/LIMCH1/PTK2B/APOE/BAIAP2L1/CDC42EP5/FLNA/COLGALT1/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/ID1/GSN/MYO1C/RHOC 23 GO:0030203 glycosaminoglycan metabolic process 16/852 118/18722 8.84794841163246e-05 0.00205215319611734 BGN/HEXB/CHPF/B3GNT7/UGDH/TGFB1/DSEL/HS6ST1/CHPF2/NAGLU/ST3GAL6/HEXA/GNS/DSE/GLB1/EXT2 16 GO:0015012 heparan sulfate proteoglycan biosynthetic process 7/852 25/18722 9.22278647209462e-05 0.00211169080028484 TCF7L2/EXTL3/UGDH/HS6ST1/CTNNB1/DSE/EXT2 7 GO:0045047 protein targeting to ER 9/852 42/18722 9.23051810178153e-05 0.00211169080028484 SEC61A1/SSR3/SEC61G/HERPUD1/SEC62/TRAM2/TRAM1/SPCS3/SEC63 9 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 9/852 42/18722 9.23051810178153e-05 0.00211169080028484 TEAD1/GATA3/GATA2/SMAD3/TGFB1/TGFB2/EGR1/KLF5/TP53 9 GO:0016049 cell growth 41/852 482/18722 9.40244548156116e-05 0.00214128995966956 FN1/SERPINE2/PAPPA2/ITGB1/SFRP1/ACVRL1/PDLIM5/SEMA5A/ERBB2/CRABP2/EXTL3/PTPRS/SMAD3/ADAM15/TGFB1/TGFB2/SLC23A2/PTK2B/APOE/MFSD2A/SEMA4C/LAMB2/MMP14/ADAM10/BMPR2/SH3BP4/TIAM1/CTNNB1/DNM2/RTN4/EIF4G2/BST2/LRP1/JADE1/SEMA7A/IQGAP1/CTTN/TP53/VCL/ADAM17/MACF1 41 GO:0010718 positive regulation of epithelial to mesenchymal transition 10/852 52/18722 0.00010037752735118 0.00227567610431752 ENG/TCF7L2/SMAD3/WWTR1/TGFB1/TGFB2/TIAM1/CTNNB1/ZNF703/MDK 10 GO:0030111 regulation of Wnt signaling pathway 31/852 328/18722 0.000102493878041335 0.00231323626987462 NOTUM/NOG/SFRP1/TCF7L2/SEMA5A/SMAD3/WWTR1/TGFB1/APOE/SOX4/PLPP3/TNFAIP3/TNKS2/TIAM1/TLE3/TPBG/EGR1/CCNYL1/LRP1/JADE1/MBD2/CSNK1A1/SPIN1/XIAP/ZNF703/GNAQ/MDK/AMFR/JUP/CTDNEP1/MACF1 31 GO:2000146 negative regulation of cell motility 33/852 359/18722 0.000105914814703476 0.00237977349286873 TPM1/SERPINE1/IGFBP3/ENG/NOG/SFRP1/FBLN1/CITED2/PTN/GATA3/TIMP1/CLDN19/ACVRL1/ARHGDIB/ADAM15/TGFB1/LIMCH1/APOE/PHLDB2/SRGAP2C/CNN2/CLIC4/SRGAP2/CALR/HDAC5/DAG1/BST2/LRP1/EVL/MIF/VCL/JUP/DPP4 33 GO:0048675 axon extension 16/852 120/18722 0.000108378846102323 0.00241850329225946 FN1/ITGB1/SEMA5A/PTPRS/APOE/SEMA4C/LAMB2/BMPR2/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/CTTN/VCL/MACF1 16 GO:0007369 gastrulation 21/852 185/18722 0.00010868829050166 0.00241850329225946 FN1/COL4A2/ITGA5/NOG/ITGB1/SFRP1/MMP2/SMAD3/UGDH/COL6A1/MYADM/PHLDB2/MMP14/BMPR2/DUSP4/CTNNB1/DAG1/LMBRD1/TP53/ETS2/EXT2 21 GO:0034620 cellular response to unfolded protein 14/852 96/18722 0.000109080120672143 0.00241850329225946 ABCA7/XBP1/OS9/TMED2/WFS1/ATF3/CREB3L2/HERPUD1/PPP1R15B/ERO1A/TMBIM6/AMFR/PIK3R1/ATF4 14 GO:0061383 trabecula morphogenesis 9/852 43/18722 0.000112072434463953 0.00245837085526564 ENG/NOG/SFRP1/ADAMTS1/MMP2/TGFB2/FHL2/FBN2/TGFBR3 9 GO:0044319 wound healing, spreading of cells 8/852 34/18722 0.000112470127406541 0.00245837085526564 ITGA5/ACVRL1/FLNA/CD151/PHLDB2/RREB1/ADAM17/RHOC 8 GO:0090505 epiboly involved in wound healing 8/852 34/18722 0.000112470127406541 0.00245837085526564 ITGA5/ACVRL1/FLNA/CD151/PHLDB2/RREB1/ADAM17/RHOC 8 GO:1990138 neuron projection extension 20/852 172/18722 0.000112832042035836 0.00245837085526564 FN1/ITGB1/SEMA5A/PTPRS/SLC23A2/APOE/SEMA4C/LAMB2/BMPR2/TIAM1/CTNNB1/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/IQGAP1/CTTN/VCL/MACF1 20 GO:0022617 extracellular matrix disassembly 11/852 63/18722 0.000114380648921437 0.00247072019751756 MMP11/MMP2/ADAM15/SH3PXD2B/TGFB1/MMP14/ADAM10/LRP1/LAMC1/FURIN/DPP4 11 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 11/852 63/18722 0.000114380648921437 0.00247072019751756 XBP1/WFS1/HERPUD1/SERINC3/DNAJC10/TP53/ERO1A/TMBIM6/UBE2K/ATF4/ERP29 11 GO:0030433 ubiquitin-dependent ERAD pathway 13/852 85/18722 0.000116241675039883 0.00250018953194756 OS9/WFS1/CANX/CALR/HSP90B1/FAM8A1/HERPUD1/MAN1B1/SEL1L/DNAJC10/STT3B/AMFR/EDEM3 13 GO:0001838 embryonic epithelial tube formation 16/852 121/18722 0.000119720490145248 0.00255319163941115 NOG/SFRP1/ADM/CITED2/GATA3/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/CTNNB1/SPINT1 16 GO:1904019 epithelial cell apoptotic process 16/852 121/18722 0.000119720490145248 0.00255319163941115 SERPINE1/HLA-G/TCF7L2/GATA3/SEMA5A/GATA2/ANGPTL4/KRT8/TNFAIP3/WFS1/BMPR2/ZFP36L1/SRSF6/MDK/GSN/KRT18 16 GO:0006517 protein deglycosylation 7/852 26/18722 0.000121278618096895 0.00257550753114631 MAN2A1/AGA/MAN1B1/RNF139/MAN1A2/AMFR/EDEM3 7 GO:0016331 morphogenesis of embryonic epithelium 18/852 147/18722 0.000126573423853856 0.00267665563973301 NOG/SFRP1/ADM/CITED2/GATA3/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/CTNNB1/LAMA5/RDH10/SPINT1 18 GO:0051056 regulation of small GTPase mediated signal transduction 29/852 302/18722 0.000128733204304054 0.00271093814754101 TIMP2/ITGB1/F11R/ARHGDIB/RASGRF2/IQSEC1/TGFB2/APOE/MAPRE2/EPHB2/RALBP1/RHOU/NOTCH2/PLEKHG6/SRGAP2/ABCA1/ARHGEF2/RHOD/TIAM1/DNM2/CDC42SE1/PIK3CB/ARHGAP1/TRIO/CDC42SE2/MYO9B/ARHGAP29/SGSM3/EPS8L2 29 GO:0031667 response to nutrient levels 40/852 474/18722 0.000135032032137852 0.0028317342406242 AOC1/SPARC/SFRP1/ADM/PTN/GDF15/TSPO/PRKAG2/POMC/LPL/CSH1/NUAK1/PCSK1N/APOE/MFSD2A/XBP1/GCN1/EIF4EBP1/ABCA1/ATF3/BMPR2/DAP/WIPI1/NUCB2/GBA/NCOA1/LIPG/LDLR/ACSL4/MBD2/MAPK3/KLF10/TP53/KRT18/LAMP2/ATF4/SLC16A1/ACSL3/SH3GLB1/MBD3 40 GO:0003205 cardiac chamber development 19/852 161/18722 0.00013635381255863 0.00284758812700243 TPM1/ENG/NOG/CITED2/GATA3/ADAMTS1/TGFB1/TGFB2/SOX4/PARVA/PKP2/NOTCH2/BMPR2/GRHL2/FHL2/DHRS3/GJA5/TP53/TGFBR3 19 GO:0090504 epiboly 8/852 35/18722 0.00014002916240625 0.00291225939830849 ITGA5/ACVRL1/FLNA/CD151/PHLDB2/RREB1/ADAM17/RHOC 8 GO:0052126 movement in host environment 20/852 175/18722 0.000143187155354073 0.00296568293373272 ITGA5/ITGB1/F11R/P4HB/PVR/SCARB1/CTSL/CTSB/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/CAV2/FUCA2/BSG/ARL8B/DDB1/GSN/DPP4 20 GO:0046578 regulation of Ras protein signal transduction 21/852 189/18722 0.000147316713115973 0.00303730462483709 TIMP2/ITGB1/F11R/ARHGDIB/RASGRF2/IQSEC1/TGFB2/APOE/MAPRE2/EPHB2/RALBP1/NOTCH2/ABCA1/ARHGEF2/DNM2/CDC42SE1/PIK3CB/CDC42SE2/MYO9B/SGSM3/EPS8L2 21 GO:0016055 Wnt signaling pathway 38/852 444/18722 0.000147999316756989 0.00303730462483709 NOTUM/NOG/SFRP1/TCF7L2/GATA3/SEMA5A/SMAD3/WWTR1/TGFB1/GPC4/APOE/SOX4/PLPP3/TNFAIP3/TNKS2/AMOTL2/TIAM1/SDC1/TLE3/CTNNB1/TPBG/EGR1/CCNYL1/LRP1/JADE1/MBD2/CSNK1A1/SPIN1/XIAP/ZNF703/DDB1/GNAQ/MDK/AMFR/JUP/CCNE1/CTDNEP1/MACF1 38 GO:0006643 membrane lipid metabolic process 22/852 203/18722 0.000149059058679666 0.00303730462483709 HEXB/PSAP/UGCG/SGMS2/GM2A/FADS3/PIGT/PLPP3/PRKD3/SGPP1/TECR/GBA/CERS6/ST3GAL6/B4GALT4/HEXA/B4GALT5/SERINC3/GLB1/NEU1/GPAA1/SERINC2 22 GO:0051701 biological process involved in interaction with host 22/852 203/18722 0.000149059058679666 0.00303730462483709 ITGA5/ITGB1/F11R/P4HB/PVR/SCARB1/CTSL/INSR/CTSB/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/CAV2/FUCA2/BSG/RXRA/ARL8B/DDB1/GSN/DPP4 22 GO:0044403 biological process involved in symbiotic interaction 28/852 290/18722 0.000152422077219766 0.00308113024323 FN1/ITGA5/ITGB1/F11R/P4HB/IFI27/PVR/APOE/SCARB1/CTSL/INSR/CTSB/SLC1A5/SCARB2/PPIB/DAG1/LAMP1/LDLR/CAV2/IGF2R/FUCA2/BSG/RXRA/ARL8B/DDB1/GSN/FMR1/DPP4 28 GO:0021549 cerebellum development 14/852 99/18722 0.000152710821876659 0.00308113024323 SERPINE2/PTN/PTPRS/HERC1/SEMA4C/GBA/SDF4/NCOA1/NAGLU/ATRN/TP53/ARCN1/MDK/NCSTN 14 GO:0060389 pathway-restricted SMAD protein phosphorylation 11/852 65/18722 0.000153046405882674 0.00308113024323 ENG/NOG/GDF15/ACVRL1/TGFB1/TGFB2/INHA/BMPR2/LRP1/TGFBR3/RBPMS 11 GO:0045685 regulation of glial cell differentiation 12/852 76/18722 0.000154572181839168 0.00309339013223156 SERPINE2/IL6ST/NOG/PTN/TGFB1/CTNNB1/DAG1/LDLR/MYCN/MDK/RHEB/SPINT1 12 GO:0052547 regulation of peptidase activity 39/852 461/18722 0.000154884624145113 0.00309339013223156 FN1/SERPINE2/TIMP3/SERPINE1/TNFSF10/TIMP2/EGLN3/SERPING1/TFPI/FBLN1/TIMP1/CST6/RCN3/SMAD3/PCSK1N/HIP1/SERPINH1/GRN/RPS27L/CRIM1/EFNA1/PRSS22/DAP/PICALM/DAPK1/TMED10/PINK1/BST2/TBC1D10A/LRP1/NLRP2/HERPUD1/FURIN/CTSH/XIAP/NCSTN/GSN/SPINT1/SERPINB6 39 GO:0032535 regulation of cellular component size 34/852 382/18722 0.000156032505409005 0.00310399841787953 FN1/COTL1/SEMA5A/CRABP2/TMSB10/PTPRS/SLC12A8/CAPG/PTK2B/ESAM/APOE/BAIAP2L1/CDC42EP5/MYADM/LIMA1/SEMA4C/VASP/NCKAP1/BMPR2/DNM2/PICALM/RTN4/EIF4G2/CDC42EP1/DSTN/LRP1/EVL/SEMA7A/CTTN/SSH2/EZR/GSN/MYO1C/MACF1 34 GO:0198738 cell-cell signaling by wnt 38/852 446/18722 0.000162190765554448 0.00321380363399817 NOTUM/NOG/SFRP1/TCF7L2/GATA3/SEMA5A/SMAD3/WWTR1/TGFB1/GPC4/APOE/SOX4/PLPP3/TNFAIP3/TNKS2/AMOTL2/TIAM1/SDC1/TLE3/CTNNB1/TPBG/EGR1/CCNYL1/LRP1/JADE1/MBD2/CSNK1A1/SPIN1/XIAP/ZNF703/DDB1/GNAQ/MDK/AMFR/JUP/CCNE1/CTDNEP1/MACF1 38 GO:0001843 neural tube closure 13/852 88/18722 0.000166628915825331 0.00328879738568192 NOG/SFRP1/ADM/CITED2/SDC4/PLXNB2/TGFB1/TGFB2/SEMA4C/TMED2/VASP/GRHL2/SPINT1 13 GO:0060840 artery development 14/852 100/18722 0.000170269450938232 0.00333259240834651 HPGD/ENG/NOG/FKBP10/CITED2/ACVRL1/TGFB2/APOE/SOX4/BMPR2/GJA5/LDLR/LRP1/MDK 14 GO:0097191 extrinsic apoptotic signaling pathway 23/852 219/18722 0.000170549980635984 0.00333259240834651 TIMP3/SERPINE1/TNFSF10/FGFR1/SFRP1/TCF7L2/IFI27/SMAD3/TGFB1/TGFB2/KRT8/TNFAIP3/ARHGEF2/ATF3/PEA15/SGPP1/ERBB3/LGALS3/CTTN/PDIA3/ITM2C/PIK3R1/KRT18 23 GO:0050821 protein stabilization 21/852 191/18722 0.000170834262140552 0.00333259240834651 SMAD3/HIP1/SOX4/FLNA/PARVA/GRN/P3H1/PLPP3/EFNA1/WFS1/CALR/PPIB/RTN4/LAMP1/PINK1/SEC16A/SEL1L/TP53/GNAQ/PIK3R1/LAMP2 21 GO:0007492 endoderm development 12/852 77/18722 0.000175646273513904 0.00341323434206749 FN1/COL4A2/ITGA5/NOG/MMP2/SMAD3/COL6A1/MMP14/DUSP4/CTNNB1/ZFP36L1/LAMC1 12 GO:0044409 entry into host 18/852 151/18722 0.000178398221611786 0.00344014654931847 ITGA5/ITGB1/F11R/P4HB/PVR/SCARB1/CTSL/CTSB/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/CAV2/FUCA2/BSG/GSN/DPP4 18 GO:0048592 eye morphogenesis 18/852 151/18722 0.000178398221611786 0.00344014654931847 MFAP5/FBN1/CITED2/PTN/MFAP2/MFSD2A/EPHB2/NOTCH2/MAN2A1/FAT1/CTNNB1/NAGLU/C12orf57/FBN2/BCAR3/TUG1/ATF4/OBSL1 18 GO:0048705 skeletal system morphogenesis 23/852 220/18722 0.000182469833266435 0.0034992698648408 PAPPA2/FGFR1/NOG/SFRP1/CITED2/MMP2/SMAD3/COL27A1/SERPINH1/BMP1/MMP14/INSIG1/LTBP3/BMPR2/GRHL2/DHRS3/CTNNB1/PLEKHA1/FBN2/MYCN/RDH10/INPPL1/EXT2 23 GO:0060670 branching involved in labyrinthine layer morphogenesis 5/852 13/18722 0.000182854753517411 0.0034992698648408 ADM/GCM1/TMED2/GRHL2/SPINT1 5 GO:0060606 tube closure 13/852 89/18722 0.00018714236735548 0.00356775581401565 NOG/SFRP1/ADM/CITED2/SDC4/PLXNB2/TGFB1/TGFB2/SEMA4C/TMED2/VASP/GRHL2/SPINT1 13 GO:0006984 ER-nucleus signaling pathway 9/852 46/18722 0.000193754751809243 0.0036660438566012 ABCA7/TMED2/INSIG1/WFS1/PPP1R15B/TP53/AMFR/TMCO1/ATF4 9 GO:0072599 establishment of protein localization to endoplasmic reticulum 9/852 46/18722 0.000193754751809243 0.0036660438566012 SEC61A1/SSR3/SEC61G/HERPUD1/SEC62/TRAM2/TRAM1/SPCS3/SEC63 9 GO:0002683 negative regulation of immune system process 37/852 434/18722 0.000194501931878156 0.003666397839486 FSTL3/HTRA1/HLA-G/FBN1/SERPING1/SFRP1/PLCL2/SDC4/ERBB2/GATA2/TGFB1/TGFB2/INHA/GRN/CD59/ISG15/TNFAIP3/PKN1/PLK2/CBLB/CTNNB1/UBASH3B/STAT2/BST2/LDLR/DGKZ/LGALS3/MIF/FURIN/EZR/NDFIP1/TMBIM6/SEC14L1/MDK/PIK3R1/PCBP2/DPP4 37 GO:1903317 regulation of protein maturation 11/852 67/18722 0.000202285669674878 0.0037988946846032 SERPINE2/SERPINE1/IL1R2/SOX4/TMEM59/MMP14/MYH9/CTSZ/RNF139/XIAP/GSN 11 GO:0046849 bone remodeling 13/852 90/18722 0.000209785099201119 0.00392508700475551 SFRP1/PTN/TGFB1/PTK2B/P3H4/NOTCH2/CSF1R/LTBP3/TNFAIP3/CTNNB1/UBASH3B/MDK/ATP6AP1 13 GO:0001841 neural tube formation 14/852 102/18722 0.000210669466878848 0.00392703491407868 NOG/SFRP1/ADM/CITED2/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/SPINT1 14 GO:0002573 myeloid leukocyte differentiation 22/852 208/18722 0.000211674803171228 0.00393121507144203 FSTL3/FBN1/SFRP1/CITED2/GATA3/GATA2/SH3PXD2A/TGFB1/INHA/CCR1/NOTCH2/CSF1R/CTNNB1/GBA/MYH9/UBASH3B/ZFP36L1/KLF10/OSTM1/NDFIP1/PIK3R1/ATP6AP1 22 GO:0050768 negative regulation of neurogenesis 17/852 140/18722 0.000213758993187658 0.00395532725262309 ASCL2/NOG/PTN/TSPO/SEMA5A/PTPRS/EPHB2/SEMA4C/CTNNB1/RTN4/LDLR/SEMA7A/MYCN/CTDSP1/PPP3CA/TP53/ID1 17 GO:0033673 negative regulation of kinase activity 24/852 237/18722 0.000216829647405947 0.00399744914063784 SFRP1/SH3BP5/PRKAG2/WWTR1/CAMK2N1/GPRC5A/APOE/EPHB2/CDKN1C/SMYD3/HSPB1/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/PIK3CB/PRKAR2A/HIPK3/GNAQ/ERRFI1/IPO7 24 GO:0002011 morphogenesis of an epithelial sheet 10/852 57/18722 0.000223103818795461 0.00409810773721736 ITGA5/ACVRL1/FLNA/CD151/NOTCH2/PHLDB2/DAG1/RREB1/ADAM17/RHOC 10 GO:0006023 aminoglycan biosynthetic process 12/852 79/18722 0.000225227023321942 0.00410712901586715 CHPF/B3GNT7/UGDH/TGFB1/DSEL/HS6ST1/CHPF2/ST3GAL6/HEXA/B4GALT5/DSE/EXT2 12 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 12/852 79/18722 0.000225227023321942 0.00410712901586715 DOCK5/P4HB/MYADM/FLNA/CALR/TIAM1/DNM2/ARHGEF7/MDK/RREB1/CUX1/OBSL1 12 GO:0042987 amyloid precursor protein catabolic process 11/852 68/18722 0.000231550876119194 0.00419182638647321 ADAM19/ABCA7/APOE/EFNA1/ADAM10/PICALM/RTN4/TMED10/NCSTN/RTN2/ADAM17 11 GO:0060411 cardiac septum morphogenesis 11/852 68/18722 0.000231550876119194 0.00419182638647321 ENG/NOG/CITED2/TGFB2/SOX4/PARVA/NOTCH2/BMPR2/DHRS3/TP53/TGFBR3 11 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 16/852 128/18722 0.000232370268592495 0.00419182638647321 HTRA1/HTRA4/LTBP1/ENG/FBN1/CITED2/SMAD3/TGFB1/CDKN1C/DNM2/CAV2/FBN2/TP53/ZNF703/ADAM17/TGFBR3 16 GO:0014013 regulation of gliogenesis 14/852 103/18722 0.000233791515139087 0.00420240248462508 SERPINE2/IL6ST/ASCL2/NOG/PTN/TSPO/TGFB1/CTNNB1/DAG1/LDLR/MYCN/MDK/RHEB/SPINT1 14 GO:0001894 tissue homeostasis 26/852 268/18722 0.000239839631404318 0.00429577531977913 EPAS1/ITGB1/F11R/JAM2/RCN3/GATA2/WWTR1/SLC39A8/LPCAT1/PTK2B/ESAM/MFSD2A/CSF1R/ACTB/HSPB1/LTBP3/TNFAIP3/CTNNB1/UBASH3B/LAMC1/P2RX4/CTSH/LSR/TJP2/VCL/ATP6AP1 26 GO:0030336 negative regulation of cell migration 31/852 344/18722 0.000241073000211389 0.00430255464561674 TPM1/SERPINE1/IGFBP3/ENG/NOG/SFRP1/CITED2/PTN/TIMP1/CLDN19/ACVRL1/ARHGDIB/ADAM15/TGFB1/LIMCH1/APOE/PHLDB2/SRGAP2C/CNN2/CLIC4/SRGAP2/CALR/HDAC5/DAG1/BST2/LRP1/EVL/MIF/VCL/JUP/DPP4 31 GO:0006665 sphingolipid metabolic process 18/852 155/18722 0.000247916198203757 0.00439842778441982 HEXB/PSAP/UGCG/SGMS2/GM2A/FADS3/PLPP3/PRKD3/SGPP1/TECR/GBA/CERS6/HEXA/B4GALT5/SERINC3/GLB1/NEU1/SERINC2 18 GO:0035967 cellular response to topologically incorrect protein 15/852 116/18722 0.000248192626818047 0.00439842778441982 ABCA7/XBP1/OS9/TMED2/WFS1/ATF3/CREB3L2/HERPUD1/PPP1R15B/ERO1A/TMBIM6/AMFR/PIK3R1/ATF4/SDF2L1 15 GO:0048246 macrophage chemotaxis 8/852 38/18722 0.000257823863925974 0.00455307897241904 PTK2B/EDNRB/CSF1R/PTK2/LGALS3/MIF/MAPK3/MDK 8 GO:1903076 regulation of protein localization to plasma membrane 14/852 104/18722 0.0002590624232508 0.00455895516161285 ITGB1/TGFB1/ARHGEF16/EPHB2/TMEM59/ACTB/MMP14/PICALM/LRP1/LGALS3/EZR/LYPLA1/PIK3R1/ACSL3 14 GO:0048199 vesicle targeting, to, from or within Golgi 6/852 21/18722 0.000262914000672488 0.0046106138166712 TMED2/WIPI1/TMED10/SAR1A/TMED9/ARFGAP3 6 GO:0009267 cellular response to starvation 18/852 156/18722 0.000268605620588405 0.00469406975146334 AOC1/SFRP1/PRKAG2/NUAK1/MFSD2A/XBP1/GCN1/ATF3/BMPR2/DAP/WIPI1/GBA/MAPK3/KLF10/TP53/LAMP2/ATF4/SH3GLB1 18 GO:0046479 glycosphingolipid catabolic process 5/852 14/18722 0.000273809141099873 0.00475200485226089 HEXB/GM2A/GBA/HEXA/NEU1 5 GO:1905049 negative regulation of metallopeptidase activity 5/852 14/18722 0.000273809141099873 0.00475200485226089 TIMP3/TIMP2/TIMP1/PICALM/LRP1 5 GO:0032231 regulation of actin filament bundle assembly 14/852 105/18722 0.000286643519653744 0.00495765235194946 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/FLNA/PHLDB2/EVL/ID1/PIK3R1/RHOC 14 GO:0009896 positive regulation of catabolic process 40/852 492/18722 0.000292637570127224 0.00504398935085726 LPCAT1/MEX3D/PTK2B/APOE/TMEM59/ENDOG/TNFAIP3/INSR/PLK2/SH3BP4/ADAM9/CBLB/MTDH/GBA/PABPC1/DAPK1/PINK1/SH3D19/LDLR/ANKIB1/ZFP36L1/PAFAH1B2/PTK2/LRP1/PIK3CB/HERPUD1/RNF144B/MAPK3/RNF139/FURIN/CSNK1A1/EZR/DDB1/NDFIP1/SEC22B/SGSM3/FMR1/SH3GLB1/KCNQ1OT1/TMEM259 40 GO:0019058 viral life cycle 29/852 317/18722 0.000294209860195217 0.00505378234253422 ITGA5/ITGB1/F11R/P4HB/IFI27/PVR/APOE/SCARB1/CTSL/ISG15/CTSB/SLC1A5/SCARB2/PPIB/CTBP2/PABPC1/DAG1/LAMP1/BST2/LDLR/CAV2/BSG/FURIN/ARL8B/DDB1/GSN/FMR1/PCBP2/DPP4 29 GO:0046718 viral entry into host cell 17/852 144/18722 0.000299960306288212 0.00513503476717202 ITGA5/ITGB1/F11R/P4HB/PVR/SCARB1/CTSL/CTSB/SLC1A5/SCARB2/DAG1/LAMP1/LDLR/CAV2/BSG/GSN/DPP4 17 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 16/852 131/18722 0.000303594906885121 0.00517963785204344 HTRA1/HTRA4/LTBP1/ENG/FBN1/CITED2/SMAD3/TGFB1/CDKN1C/DNM2/CAV2/FBN2/TP53/ZNF703/ADAM17/TGFBR3 16 GO:2000249 regulation of actin cytoskeleton reorganization 8/852 39/18722 0.000311562601181128 0.00529761679643451 F11R/ARHGDIB/PTK2B/ESAM/BAIAP2L1/NOTCH2/CSF1R/MDK 8 GO:0060070 canonical Wnt signaling pathway 28/852 303/18722 0.000315439588278295 0.0053454796222379 NOTUM/NOG/SFRP1/TCF7L2/GATA3/SEMA5A/SMAD3/WWTR1/TGFB1/APOE/SOX4/PLPP3/TNKS2/SDC1/TLE3/CTNNB1/TPBG/EGR1/CCNYL1/JADE1/CSNK1A1/XIAP/ZNF703/GNAQ/MDK/AMFR/JUP/CTDNEP1 28 GO:0002690 positive regulation of leukocyte chemotaxis 13/852 94/18722 0.000325368573026153 0.00542826433618314 SERPINE1/PTN/PLA2G7/PTK2B/CCR1/PGF/CSF1R/CALR/ADAM10/PTK2/MAPK3/MDK/ADAM17 13 GO:0014020 primary neural tube formation 13/852 94/18722 0.000325368573026153 0.00542826433618314 NOG/SFRP1/ADM/CITED2/SDC4/PLXNB2/TGFB1/TGFB2/SEMA4C/TMED2/VASP/GRHL2/SPINT1 13 GO:0019080 viral gene expression 13/852 94/18722 0.000325368573026153 0.00542826433618314 MGAT5/MGAT4A/MAN2A1/MGAT1/MGAT2/CANX/MAN1B1/MGAT4B/FURIN/GALNT1/MOGS/SPCS3/PCBP2 13 GO:0030316 osteoclast differentiation 13/852 94/18722 0.000325368573026153 0.00542826433618314 FSTL3/FBN1/SFRP1/SH3PXD2A/CCR1/NOTCH2/CSF1R/CTNNB1/UBASH3B/KLF10/OSTM1/PIK3R1/ATP6AP1 13 GO:0051961 negative regulation of nervous system development 17/852 145/18722 0.000325717430861774 0.00542826433618314 ASCL2/NOG/PTN/TSPO/SEMA5A/PTPRS/EPHB2/SEMA4C/CTNNB1/RTN4/LDLR/SEMA7A/MYCN/CTDSP1/PPP3CA/TP53/ID1 17 GO:0045444 fat cell differentiation 23/852 229/18722 0.000327552960585265 0.00544083845090971 DIO2/PLAC8/SFRP1/TCF7L2/GATA3/MMP11/GATA2/LPL/SMAD3/WWTR1/TGFB1/XBP1/INSIG1/CARM1/CTBP2/SDF4/ZFP36L1/AAMDC/TRIO/ERAP1/KLF5/ERO1A/RREB1 23 GO:0035264 multicellular organism growth 16/852 132/18722 0.000331193793778026 0.00546524053798297 IGF2/PLAC8/GDF15/WWTR1/MFSD2A/NOTCH2/TMED2/CLIC4/TNKS2/GRHL2/PPIB/PLEKHA1/ZFP36L1/ATRN/EZR/TP53 16 GO:0072175 epithelial tube formation 16/852 132/18722 0.000331193793778026 0.00546524053798297 NOG/SFRP1/ADM/CITED2/GATA3/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/CTNNB1/SPINT1 16 GO:0045927 positive regulation of growth 25/852 259/18722 0.000338380498855709 0.00556558513313981 FN1/IGF2/SFRP1/SEMA5A/ERBB2/CRABP2/EXTL3/CSH1/TGFB2/SLC23A2/PTK2B/MFSD2A/MMP14/INSR/WFS1/ADAM10/BMPR2/PPIB/EIF4G2/LRP1/SEMA7A/EZR/ADAM17/TGFBR3/MACF1 25 GO:0031102 neuron projection regeneration 10/852 60/18722 0.000344416298625817 0.0056464079185138 PTPRF/ADM/PTN/TSPO/PTPRS/FLNA/GRN/LAMB2/DAG1/LRP1 10 GO:0060343 trabecula formation 6/852 22/18722 0.000347676744186268 0.00568135406977107 SFRP1/ADAMTS1/MMP2/FHL2/FBN2/TGFBR3 6 GO:0007043 cell-cell junction assembly 17/852 146/18722 0.000353367910181119 0.00575566566971383 CD9/F11R/CLDN19/ESAM/PKP2/ACTB/GRHL2/MTDH/CTNNB1/GJA5/LSR/ZNF703/VCL/JUP/PKP3/MYO1C/RHOC 17 GO:0002761 regulation of myeloid leukocyte differentiation 15/852 120/18722 0.000360442481092137 0.00583224772614295 FSTL3/FBN1/SFRP1/GATA2/TGFB1/INHA/CCR1/NOTCH2/CTNNB1/UBASH3B/ZFP36L1/KLF10/NDFIP1/PIK3R1/ATP6AP1 15 GO:0030516 regulation of axon extension 13/852 95/18722 0.000361546054153904 0.00583224772614295 FN1/SEMA5A/PTPRS/APOE/SEMA4C/BMPR2/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/CTTN/MACF1 13 GO:0042982 amyloid precursor protein metabolic process 13/852 95/18722 0.000361546054153904 0.00583224772614295 ITM2B/ADAM19/ABCA7/APOE/EFNA1/ADAM10/PICALM/RTN4/TMED10/ITM2C/NCSTN/RTN2/ADAM17 13 GO:0007173 epidermal growth factor receptor signaling pathway 14/852 108/18722 0.000384996083666431 0.00616342027398818 ITGA1/REPS2/TGFB1/GPRC5A/PTK2B/HIP1/CBLB/PTK2/ARF4/IQGAP1/BCAR3/PTPN3/ERRFI1/ADAM17 14 GO:0022037 metencephalon development 14/852 108/18722 0.000384996083666431 0.00616342027398818 SERPINE2/PTN/PTPRS/HERC1/SEMA4C/GBA/SDF4/NCOA1/NAGLU/ATRN/TP53/ARCN1/MDK/NCSTN 14 GO:0033627 cell adhesion mediated by integrin 11/852 72/18722 0.000386974132044559 0.00616342027398818 SERPINE1/ITGA5/FBN1/ITGB1/TGFB2/PLPP3/EFNA1/ADAM9/PTK2/ADAM17/DPP4 11 GO:1903036 positive regulation of response to wounding 11/852 72/18722 0.000386974132044559 0.00616342027398818 SERPINE1/ITGB1/PTN/FLNA/GRN/XBP1/PLPP3/PTK2/LRP1/MDK/RREB1 11 GO:0001655 urogenital system development 30/852 338/18722 0.000390074767353151 0.00619320600658805 FSTL3/HPGD/COL4A1/FBN1/NOG/SFRP1/GATA3/ADAMTS1/SDC4/PSAP/GATA2/SMAD3/WWTR1/TGFB2/EPHB2/ID3/SOX4/NOTCH2/LAMB2/WFS1/SDC1/CTNNB1/SEC61A1/TMED10/LAMA5/EGR1/MAGED1/IQGAP1/RDH10/CTSH 30 GO:0038127 ERBB signaling pathway 15/852 121/18722 0.0003945069137733 0.00621858876536238 ITGA1/REPS2/TGFB1/GPRC5A/PTK2B/HIP1/CBLB/RTN4/PTK2/ARF4/IQGAP1/BCAR3/PTPN3/ERRFI1/ADAM17 15 GO:0034638 phosphatidylcholine catabolic process 5/852 15/18722 0.000395380171848989 0.00621858876536238 APOC1/PLA2G7/GDPD3/SCARB1/LDLR 5 GO:0070831 basement membrane assembly 5/852 15/18722 0.000395380171848989 0.00621858876536238 PLOD3/NTN4/LAMB2/PHLDB2/DAG1 5 GO:0030510 regulation of BMP signaling pathway 13/852 96/18722 0.000401088911205263 0.0062691940686214 FSTL3/HTRA1/FSTL1/ENG/FBN1/NOG/SFRP1/ACVRL1/PCSK6/NOTCH2/CRIM1/BMPR2/XIAP 13 GO:1904035 regulation of epithelial cell apoptotic process 13/852 96/18722 0.000401088911205263 0.0062691940686214 SERPINE1/HLA-G/TCF7L2/GATA3/SEMA5A/GATA2/ANGPTL4/TNFAIP3/WFS1/ZFP36L1/SRSF6/MDK/GSN 13 GO:1901888 regulation of cell junction assembly 21/852 204/18722 0.000421449925495211 0.00656705100624581 SFRP1/IL1RAP/F11R/CLDN19/SDC4/ACVRL1/PDLIM5/PTPRS/SMAD3/LIMCH1/GPC4/EPHB2/PHLDB2/MMP14/TPBG/PTK2/LRP1/IQGAP1/VCL/MYO1C/MACF1 21 GO:0002688 regulation of leukocyte chemotaxis 15/852 122/18722 0.000431295002465111 0.00669971526977439 SERPINE1/PTN/PLA2G7/PTK2B/CCR1/PGF/CSF1R/CALR/ADAM10/PTK2/MIF/MAPK3/MDK/ADAM17/DPP4 15 GO:0060560 developmental growth involved in morphogenesis 23/852 234/18722 0.000445709782749569 0.00690233026639563 FN1/ITGB1/SFRP1/SEMA5A/CRABP2/PTPRS/SLC23A2/APOE/SEMA4C/LAMB2/BMPR2/TIAM1/CTNNB1/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/IQGAP1/CTTN/RDH10/VCL/MACF1 23 GO:0045926 negative regulation of growth 24/852 249/18722 0.000450348564860317 0.00692263323265292 SERPINE2/PLAC8/NOG/SFRP1/CITED2/GDF15/ACVRL1/SEMA5A/MT1X/PTPRS/SMAD3/ADAM15/TGFB1/TGFB2/SEMA4C/NOTCH2/WWC3/BMPR2/SH3BP4/RTN4/BST2/JADE1/SEMA7A/TP53 24 GO:0097006 regulation of plasma lipoprotein particle levels 12/852 85/18722 0.000451024105755536 0.00692263323265292 APOC1/PLA2G7/LPL/ABCA7/APOE/MFSD2A/SCARB1/ABCA1/LIPG/LDLR/CNPY2/ACSL3 12 GO:0060135 maternal process involved in female pregnancy 10/852 62/18722 0.000452522617433501 0.00692263323265292 CITED2/PTN/PAM/TMED2/CTSB/BMPR2/ADCY7/MAPK3/BSG/UBE2A 10 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 10/852 62/18722 0.000452522617433501 0.00692263323265292 ENG/NOG/GDF15/ACVRL1/TGFB1/TGFB2/INHA/BMPR2/LRP1/RBPMS 10 GO:0051047 positive regulation of secretion 28/852 310/18722 0.000455810369665628 0.00695179875917305 TCF7L2/PTGES/SDC4/GATA2/CAMK2N1/TGFB1/TGFB2/INHA/SOX4/EDNRB/XBP1/STXBP5/RAB8B/SDC1/ADAM9/TMED10/LAMP1/PINK1/ACSL4/LRP1/P2RX4/AP1G1/EZR/GOLPH3/ACSL3/SRI/ATP6AP1/FRMD4A 28 GO:0097529 myeloid leukocyte migration 22/852 220/18722 0.000464477270398901 0.00705658312749397 FLT1/SERPINE1/IL1R1/CD9/ITGA1/PLA2G7/TGFB2/PTK2B/CCR1/EDNRB/PGF/CSF1R/MMP14/PPIB/PTK2/LGALS3/MIF/MAPK3/BSG/P2RX4/MDK/DPP4 22 GO:0061387 regulation of extent of cell growth 14/852 110/18722 0.000465484919198887 0.00705658312749397 FN1/SEMA5A/CRABP2/PTPRS/APOE/SEMA4C/BMPR2/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/CTTN/MACF1 14 GO:0030168 platelet activation 15/852 123/18722 0.000470981856293655 0.0071184735216996 FN1/SERPINE2/IL6ST/CD9/F11R/APOE/FLNA/ACTB/HSPB1/MYH9/UBASH3B/DGKZ/PIK3CB/VCL/CSRP1 15 GO:0060317 cardiac epithelial to mesenchymal transition 7/852 32/18722 0.000488950024944655 0.0073679205854684 ENG/NOG/ADAM15/TGFB2/EFNA1/RTN4/TGFBR3 7 GO:0046470 phosphatidylcholine metabolic process 11/852 74/18722 0.000492806046554402 0.00740385920092032 APOC1/PLA2G7/LPCAT1/GDPD3/MFSD2A/SCARB1/FABP5/LDLR/SLC44A2/CAPN2/ACSL3 11 GO:0048015 phosphatidylinositol-mediated signaling 19/852 178/18722 0.00049709887751214 0.00744612693606727 FN1/SERPINE2/FLT1/FGFR1/GATA3/PLCL2/ERBB2/TGFB2/PLCD3/CSF1R/INSR/PLEKHA1/ZFP36L1/PTK2/ERBB3/PIK3CB/EZR/MYDGF/PIK3R1 19 GO:0035023 regulation of Rho protein signal transduction 12/852 86/18722 0.000502866252830996 0.00748794630324971 ITGB1/F11R/ARHGDIB/RASGRF2/APOE/RALBP1/ABCA1/ARHGEF2/CDC42SE1/CDC42SE2/MYO9B/EPS8L2 12 GO:1903510 mucopolysaccharide metabolic process 12/852 86/18722 0.000502866252830996 0.00748794630324971 BGN/CHPF/B3GNT7/UGDH/TGFB1/DSEL/CHPF2/ST3GAL6/GNS/DSE/GLB1/EXT2 12 GO:0031103 axon regeneration 9/852 52/18722 0.000506958389552745 0.00752661231451022 PTPRF/PTN/TSPO/PTPRS/FLNA/GRN/LAMB2/DAG1/LRP1 9 GO:0032233 positive regulation of actin filament bundle assembly 10/852 63/18722 0.000516322988850874 0.00764309883201897 TPM1/SFRP1/SDC4/PXN/SMAD3/LIMCH1/FLNA/EVL/ID1/RHOC 10 GO:0030574 collagen catabolic process 8/852 42/18722 0.000529807899470244 0.00779685133927994 ITGB1/MMP11/MMP2/ADAM15/CTSL/MMP14/CTSB/FURIN 8 GO:0045687 positive regulation of glial cell differentiation 8/852 42/18722 0.000529807899470244 0.00779685133927994 SERPINE2/IL6ST/PTN/TGFB1/DAG1/MDK/RHEB/SPINT1 8 GO:0019377 glycolipid catabolic process 5/852 16/18722 0.000553652860913794 0.00806129486907012 HEXB/GM2A/GBA/HEXA/NEU1 5 GO:0044849 estrous cycle 5/852 16/18722 0.000553652860913794 0.00806129486907012 PTN/NCOR2/NCOA1/EGR1/MDK 5 GO:0051014 actin filament severing 5/852 16/18722 0.000553652860913794 0.00806129486907012 CAPG/SRGAP2/MYH9/DSTN/GSN 5 GO:0006024 glycosaminoglycan biosynthetic process 11/852 75/18722 0.000554183990601681 0.00806129486907012 CHPF/B3GNT7/UGDH/TGFB1/DSEL/HS6ST1/CHPF2/ST3GAL6/HEXA/DSE/EXT2 11 GO:0060249 anatomical structure homeostasis 28/852 314/18722 0.000558603935782456 0.00810217178326543 EPAS1/ITGB1/SLC6A2/F11R/JAM2/RCN3/GATA2/WWTR1/SLC39A8/LPCAT1/PTK2B/ESAM/MFSD2A/GAA/CSF1R/ACTB/HSPB1/LTBP3/TNFAIP3/CTNNB1/UBASH3B/LAMC1/P2RX4/CTSH/LSR/TJP2/VCL/ATP6AP1 28 GO:0051348 negative regulation of transferase activity 25/852 268/18722 0.000563119987359892 0.0081442037252366 SFRP1/SH3BP5/PRKAG2/WWTR1/CAMK2N1/GPRC5A/APOE/EPHB2/CDKN1C/SMYD3/HSPB1/TNFAIP3/PKN1/CBLB/GBA/UBASH3B/PKIG/YWHAG/PIK3CB/PRKAR2A/HIPK3/TP53/GNAQ/ERRFI1/IPO7 25 GO:0060828 regulation of canonical Wnt signaling pathway 24/852 253/18722 0.000566711633213541 0.0081726637534778 NOTUM/NOG/SFRP1/TCF7L2/SEMA5A/SMAD3/WWTR1/TGFB1/APOE/SOX4/TNKS2/TLE3/TPBG/EGR1/CCNYL1/JADE1/CSNK1A1/XIAP/ZNF703/GNAQ/MDK/AMFR/JUP/CTDNEP1 24 GO:0030307 positive regulation of cell growth 18/852 166/18722 0.000573248470329887 0.00824331300334377 FN1/SFRP1/SEMA5A/ERBB2/CRABP2/EXTL3/TGFB2/SLC23A2/PTK2B/MFSD2A/MMP14/ADAM10/BMPR2/EIF4G2/LRP1/SEMA7A/ADAM17/MACF1 18 GO:2000310 regulation of NMDA receptor activity 6/852 24/18722 0.000580174757464791 0.00831914402940255 RASGRF2/PTK2B/EPHB2/IFNGR2/DAPK1/PINK1 6 GO:0045670 regulation of osteoclast differentiation 10/852 64/18722 0.000587397881421064 0.00839878845793243 FSTL3/FBN1/SFRP1/CCR1/NOTCH2/CTNNB1/UBASH3B/KLF10/PIK3R1/ATP6AP1 10 GO:0045598 regulation of fat cell differentiation 16/852 139/18722 0.000592242093360038 0.00844406361439397 SFRP1/GATA3/MMP11/GATA2/LPL/SMAD3/WWTR1/TGFB1/XBP1/INSIG1/CARM1/ZFP36L1/AAMDC/TRIO/KLF5/RREB1 16 GO:0034110 regulation of homotypic cell-cell adhesion 7/852 33/18722 0.000596480835516972 0.00845526384659137 SERPINE2/IL6ST/CD9/F11R/UBASH3B/JAK1/ZNF703 7 GO:0150117 positive regulation of cell-substrate junction organization 7/852 33/18722 0.000596480835516972 0.00845526384659137 SFRP1/SDC4/IQSEC1/SMAD3/MAPRE2/IQGAP1/PIK3R1 7 GO:0045807 positive regulation of endocytosis 13/852 100/18722 0.000598067540112563 0.00845526384659137 SERPINE1/GATA2/ABCA7/APOE/HIP1/CD151/CD63/INSR/DNM2/SH3GL1/LRP1/PPP3CA/FMR1 13 GO:0002685 regulation of leukocyte migration 21/852 210/18722 0.000619003243507143 0.0087267320016007 SERPINE1/IL1R1/PTN/CD9/JAM2/PLA2G7/PTK2B/CCR1/PGF/CSF1R/MMP14/CALR/ADAM10/PTK2/LGALS3/MIF/MAPK3/P2RX4/MDK/ADAM17/DPP4 21 GO:0031032 actomyosin structure organization 20/852 196/18722 0.000639790492036712 0.00896954191203557 TPM1/ITGB1/SFRP1/KRT19/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/PTK2B/KRT8/PHLDB2/CNN2/MYH9/EVL/PIK3R1/CSRP1/RHOC/OBSL1 20 GO:0043393 regulation of protein binding 20/852 196/18722 0.000639790492036712 0.00896954191203557 PTPRF/NOG/TCF7L2/PLCL2/ADAM15/APOE/ACTB/PLK2/TIAM1/CBLB/HDAC5/UBASH3B/CTSZ/LRP1/MAPK3/TMBIM6/SYMPK/AMFR/ID1/TGFBR3 20 GO:0048017 inositol lipid-mediated signaling 19/852 182/18722 0.000654495335184379 0.00915020839439717 FN1/SERPINE2/FLT1/FGFR1/GATA3/PLCL2/ERBB2/TGFB2/PLCD3/CSF1R/INSR/PLEKHA1/ZFP36L1/PTK2/ERBB3/PIK3CB/EZR/MYDGF/PIK3R1 19 GO:0070613 regulation of protein processing 10/852 65/18722 0.000666370876973497 0.00929042832079671 SERPINE2/SERPINE1/IL1R2/TMEM59/MMP14/MYH9/CTSZ/RNF139/XIAP/GSN 10 GO:0072001 renal system development 27/852 302/18722 0.000668405888631437 0.00929305756210503 FSTL3/HPGD/COL4A1/FBN1/NOG/SFRP1/GATA3/ADAMTS1/SDC4/SMAD3/WWTR1/TGFB2/ID3/SOX4/NOTCH2/LAMB2/WFS1/SDC1/CTNNB1/SEC61A1/TMED10/LAMA5/EGR1/MAGED1/IQGAP1/RDH10/CTSH 27 GO:0090596 sensory organ morphogenesis 24/852 256/18722 0.000670439918940272 0.0092956587108165 MFAP5/FBN1/NOG/CITED2/PTN/GATA3/MFAP2/GATA2/MFSD2A/EPHB2/NOTCH2/MAN2A1/INSIG1/FAT1/CTNNB1/NAGLU/C12orf57/MAPK3/MYO6/FBN2/BCAR3/TUG1/ATF4/OBSL1 24 GO:0001706 endoderm formation 9/852 54/18722 0.000675670747670744 0.00930806437907647 FN1/COL4A2/ITGA5/NOG/MMP2/COL6A1/MMP14/DUSP4/CTNNB1 9 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 9/852 54/18722 0.000675670747670744 0.00930806437907647 TEAD1/GATA3/GATA2/SMAD3/TGFB1/TGFB2/EGR1/KLF5/TP53 9 GO:0001558 regulation of cell growth 34/852 414/18722 0.000679562499015657 0.00930806437907647 FN1/SERPINE2/PAPPA2/SFRP1/ACVRL1/SEMA5A/ERBB2/CRABP2/EXTL3/PTPRS/SMAD3/ADAM15/TGFB1/TGFB2/SLC23A2/PTK2B/APOE/MFSD2A/SEMA4C/MMP14/ADAM10/BMPR2/SH3BP4/DNM2/RTN4/EIF4G2/BST2/LRP1/JADE1/SEMA7A/CTTN/TP53/ADAM17/MACF1 34 GO:0070661 leukocyte proliferation 28/852 318/18722 0.000681228259695017 0.00930806437907647 IGF2/EBI3/IL6ST/HLA-G/PLCL2/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/CD151/CSF1R/ELF4/TNFAIP3/PKN1/CBLB/CD320/CTNNB1/GBA/BST2/PTK2/LGALS3/MIF/MAPK3/TP53/NDFIP1/NCSTN 28 GO:0010952 positive regulation of peptidase activity 20/852 197/18722 0.000682431105877055 0.00930806437907647 FN1/TNFSF10/EGLN3/FBLN1/RCN3/SMAD3/HIP1/GRN/RPS27L/EFNA1/PRSS22/DAP/PICALM/DAPK1/PINK1/TBC1D10A/NLRP2/CTSH/NCSTN/GSN 20 GO:0042594 response to starvation 20/852 197/18722 0.000682431105877055 0.00930806437907647 AOC1/SFRP1/ADM/PRKAG2/NUAK1/MFSD2A/XBP1/GCN1/EIF4EBP1/ATF3/BMPR2/DAP/WIPI1/GBA/MAPK3/KLF10/TP53/LAMP2/ATF4/SH3GLB1 20 GO:0008584 male gonad development 16/852 141/18722 0.000693314733164365 0.0094055338329279 FSTL3/TNFSF10/SFRP1/CITED2/GATA3/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/NCOA1/PLEKHA1/RHOBTB3/TFAP2C 16 GO:0032355 response to estradiol 16/852 141/18722 0.000693314733164365 0.0094055338329279 HPGD/TFPI/NRIP1/SFRP1/PTN/PAM/TGFB1/ENDOG/NCOR2/CALR/CTNNB1/NCOA1/MBD2/GPX4/ZNF703/MBD3 16 GO:0007411 axon guidance 22/852 227/18722 0.000710328017980741 0.00961043256585233 NOG/GATA3/SEMA5A/PLXNB2/ERBB2/EFNB1/EPHB2/SEMA4C/NOTCH2/LAMB2/PALLD/EFNA1/VASP/BMPR2/DAG1/LAMA5/PTK2/LRP1/SEMA7A/TRIO/BSG/NPTN 22 GO:0010876 lipid localization 36/852 448/18722 0.000713819124355881 0.00963177386831943 HEXB/NRIP1/PTGES/SLCO2A1/TSPO/POMC/PSAP/APOC1/LPL/ABCA7/APOE/MFSD2A/ATP11A/UGCG/SCARB1/APOL6/LIMA1/GM2A/ABCA1/NPC2/SGPP1/SCARB2/GBA/LIPG/FABP5/LRP10/LDLR/ACSL4/LRP1/RXRA/P2RX4/FURIN/HDLBP/ARL8B/GULP1/ACSL3 36 GO:1901203 positive regulation of extracellular matrix assembly 4/852 10/18722 0.000717508874046813 0.00965567423282783 SMAD3/TGFB1/PHLDB2/DAG1 4 GO:0060711 labyrinthine layer development 8/852 44/18722 0.000734185491425675 0.00985374820892112 ADM/GCM1/PLCD3/TMED2/GRHL2/NCOA1/ZFP36L1/SPINT1 8 GO:0046546 development of primary male sexual characteristics 16/852 142/18722 0.000749139423397114 0.0100277093562704 FSTL3/TNFSF10/SFRP1/CITED2/GATA3/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/NCOA1/PLEKHA1/RHOBTB3/TFAP2C 16 GO:0097485 neuron projection guidance 22/852 228/18722 0.000753343593088754 0.0100543861504748 NOG/GATA3/SEMA5A/PLXNB2/ERBB2/EFNB1/EPHB2/SEMA4C/NOTCH2/LAMB2/PALLD/EFNA1/VASP/BMPR2/DAG1/LAMA5/PTK2/LRP1/SEMA7A/TRIO/BSG/NPTN 22 GO:0006901 vesicle coating 5/852 17/18722 0.000755127749827037 0.0100543861504748 TMED2/TMED10/SAR1A/TMED9/ARFGAP3 5 GO:0035304 regulation of protein dephosphorylation 12/852 90/18722 0.000763194615313018 0.0101349828466238 MGAT5/ITGA1/TGFB1/NUAK1/HSP90B1/GBA/RCAN1/PINK1/LGALS3/PPP1R15B/SYMPK/CAMTA1 12 GO:0000768 syncytium formation by plasma membrane fusion 9/852 55/18722 0.000775770865513175 0.0102207475436924 ADAM12/CD9/GDF15/JAM2/GCM1/SH3PXD2A/ADAM9/MYH9/CAPN2 9 GO:0061614 pri-miRNA transcription by RNA polymerase II 9/852 55/18722 0.000775770865513175 0.0102207475436924 TEAD1/GATA3/GATA2/SMAD3/TGFB1/TGFB2/EGR1/KLF5/TP53 9 GO:0140253 cell-cell fusion 9/852 55/18722 0.000775770865513175 0.0102207475436924 ADAM12/CD9/GDF15/JAM2/GCM1/SH3PXD2A/ADAM9/MYH9/CAPN2 9 GO:0030500 regulation of bone mineralization 11/852 78/18722 0.000777775940638623 0.0102207475436924 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2 11 GO:0003279 cardiac septum development 13/852 103/18722 0.000794600857370287 0.0104146513415225 ENG/NOG/CITED2/GATA3/TGFB2/SOX4/PARVA/NOTCH2/BMPR2/DHRS3/GJA5/TP53/TGFBR3 13 GO:0031669 cellular response to nutrient levels 21/852 215/18722 0.000840589635271955 0.0109887990501916 AOC1/SFRP1/PTN/PRKAG2/LPL/NUAK1/MFSD2A/XBP1/GCN1/ATF3/BMPR2/DAP/WIPI1/GBA/NCOA1/MAPK3/KLF10/TP53/LAMP2/ATF4/SH3GLB1 21 GO:0051492 regulation of stress fiber assembly 12/852 91/18722 0.000843466982798354 0.0109978479907361 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/PHLDB2/EVL/PIK3R1/RHOC 12 GO:0030595 leukocyte chemotaxis 22/852 230/18722 0.000846182537721786 0.0110047460267539 FLT1/SERPINE1/PTN/ITGA1/PLA2G7/TGFB2/PTK2B/CCR1/EDNRB/PGF/CSF1R/CALR/ADAM10/PPIB/PTK2/LGALS3/MIF/MAPK3/BSG/MDK/ADAM17/DPP4 22 GO:0031345 negative regulation of cell projection organization 19/852 186/18722 0.000853097919504906 0.0110660871878046 SEMA5A/PTPRS/APOE/EPHB2/FLNA/SEMA4C/SRGAP2C/EFNA1/DNM2/CARM1/RTN4/CTSZ/LRP1/EVL/SEMA7A/PPP3CA/ITM2C/ID1/MAP4 19 GO:0035272 exocrine system development 8/852 45/18722 0.000857830924588983 0.0110988767183968 IGF2/TGFB1/TGFB2/NTN4/IGSF3/DAG1/LAMA5/BTBD7 8 GO:0050772 positive regulation of axonogenesis 11/852 79/18722 0.000867158853733967 0.0111276097697375 FN1/SEMA5A/PLXNB2/CRABP2/METRN/BMPR2/TIAM1/EIF4G2/LRP1/SEMA7A/MACF1 11 GO:0001893 maternal placenta development 7/852 35/18722 0.000867449075867478 0.0111276097697375 CITED2/PTN/TMED2/CTSB/BMPR2/MAPK3/BSG 7 GO:0001654 eye development 31/852 371/18722 0.000868612874935975 0.0111276097697375 FLT1/MFAP5/COL4A1/FBN1/CITED2/PTN/GATA3/MFAP2/ACVRL1/SMAD3/SH3PXD2B/LPCAT1/TGFB2/MFSD2A/EPHB2/NOTCH2/LAMB2/MAN2A1/CLIC4/FAT1/BMPR2/GRHL2/CTNNB1/NAGLU/C12orf57/FBN2/BCAR3/RDH10/TUG1/ATF4/OBSL1 31 GO:0030301 cholesterol transport 14/852 117/18722 0.000869423003868582 0.0111276097697375 TSPO/APOC1/ABCA7/APOE/SCARB1/LIMA1/ABCA1/NPC2/LIPG/LDLR/LRP1/RXRA/FURIN/ARL8B 14 GO:0006892 post-Golgi vesicle-mediated transport 13/852 104/18722 0.000871106347958787 0.0111276097697375 AP3S1/WIPI1/SNAP23/DNM2/LAMP1/SEC16A/SCAMP1/AP1G1/LYPLA1/GOLPH3/KRT18/ACSL3/MACF1 13 GO:0008064 regulation of actin polymerization or depolymerization 19/852 187/18722 0.000910149284224746 0.0115969148038054 COTL1/SEMA5A/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/LIMA1/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/SSH2/GSN/MYO1C 19 GO:2001233 regulation of apoptotic signaling pathway 30/852 356/18722 0.000912520700429476 0.0115977694072261 TIMP3/SERPINE1/TNFSF10/FGFR1/NOG/SFRP1/TCF7L2/P4HB/XBP1/HSPB1/TNFAIP3/WFS1/ARHGEF2/ATF3/PEA15/CTNNB1/PINK1/MAGED1/TMEM14A/LGALS3/MIF/HERPUD1/CTTN/PDIA3/SERINC3/CTSH/TP53/ITM2C/TMBIM6/ERP29 30 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 15/852 131/18722 0.000916606742280588 0.0116107850059624 FSTL3/HTRA1/HTRA4/LTBP1/FBN1/NOG/SFRP1/CRIM1/DNM2/CAV2/LRP1/FBN2/TP53/ADAM17/TGFBR3 15 GO:1905523 positive regulation of macrophage migration 6/852 26/18722 0.000918158639454209 0.0116107850059624 CSF1R/MMP14/PTK2/MAPK3/P2RX4/MDK 6 GO:0001822 kidney development 26/852 293/18722 0.0009301844697098 0.011733379538971 FSTL3/HPGD/FBN1/NOG/SFRP1/GATA3/ADAMTS1/SDC4/SMAD3/WWTR1/TGFB2/ID3/SOX4/NOTCH2/LAMB2/WFS1/SDC1/CTNNB1/SEC61A1/TMED10/LAMA5/EGR1/MAGED1/IQGAP1/RDH10/CTSH 26 GO:0022612 gland morphogenesis 14/852 118/18722 0.000946099845279168 0.0118528772458057 NOG/SFRP1/PTN/TGFB1/TGFB2/NTN4/XBP1/NOTCH2/CSF1R/TNFAIP3/DAG1/LAMA5/BTBD7/MDK 14 GO:0045446 endothelial cell differentiation 14/852 118/18722 0.000946099845279168 0.0118528772458057 FSTL1/PTN/F11R/PLOD3/ACVRL1/PTPRS/MYADM/CLIC4/BMPR2/CTNNB1/EZR/TJP2/VCL/ID1 14 GO:0008154 actin polymerization or depolymerization 21/852 217/18722 0.00094672295903316 0.0118528772458057 COTL1/SEMA5A/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/LIMA1/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/SSH2/TTC17/MICAL3/GSN/MYO1C 21 GO:0042698 ovulation cycle 10/852 68/18722 0.000957418603260995 0.0119570417623141 NRIP1/PTN/ADAMTS1/PAM/TGFB2/NCOR2/NCOA1/PLEKHA1/EGR1/MDK 10 GO:0030832 regulation of actin filament length 19/852 188/18722 0.000970440034108329 0.0120896650783842 COTL1/SEMA5A/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/LIMA1/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/SSH2/GSN/MYO1C 19 GO:0042445 hormone metabolic process 21/852 218/18722 0.00100398158283404 0.0124485083024297 DIO2/TCF7L2/ADM/GATA3/HSD3B1/TTR/TSPO/CRABP2/PCSK1N/SCARB1/CTSL/PCSK6/CYP11A1/CTSB/DHRS3/H6PD/PLEKHA1/CTSZ/EGR1/FURIN/RDH10 21 GO:0036507 protein demannosylation 5/852 18/18722 0.0010066645895269 0.0124485083024297 MAN1B1/RNF139/MAN1A2/AMFR/EDEM3 5 GO:0036508 protein alpha-1,2-demannosylation 5/852 18/18722 0.0010066645895269 0.0124485083024297 MAN1B1/RNF139/MAN1A2/AMFR/EDEM3 5 GO:0006949 syncytium formation 9/852 57/18722 0.00101221600060585 0.0124559489756705 ADAM12/CD9/GDF15/JAM2/GCM1/SH3PXD2A/ADAM9/MYH9/CAPN2 9 GO:0034205 amyloid-beta formation 9/852 57/18722 0.00101221600060585 0.0124559489756705 ABCA7/APOE/EFNA1/ADAM10/PICALM/RTN4/TMED10/NCSTN/RTN2 9 GO:0150063 visual system development 31/852 375/18722 0.00103392262253186 0.0126156419520926 FLT1/MFAP5/COL4A1/FBN1/CITED2/PTN/GATA3/MFAP2/ACVRL1/SMAD3/SH3PXD2B/LPCAT1/TGFB2/MFSD2A/EPHB2/NOTCH2/LAMB2/MAN2A1/CLIC4/FAT1/BMPR2/GRHL2/CTNNB1/NAGLU/C12orf57/FBN2/BCAR3/RDH10/TUG1/ATF4/OBSL1 31 GO:0003230 cardiac atrium development 7/852 36/18722 0.00103509352475012 0.0126156419520926 ENG/NOG/TGFB2/SOX4/NOTCH2/BMPR2/GJA5 7 GO:0071402 cellular response to lipoprotein particle stimulus 7/852 36/18722 0.00103509352475012 0.0126156419520926 ITGB1/CD9/LPL/APOE/ABCA1/LDLR/ADAM17 7 GO:0030038 contractile actin filament bundle assembly 13/852 106/18722 0.00104273488553967 0.0126156419520926 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/PTK2B/PHLDB2/EVL/PIK3R1/RHOC 13 GO:0043149 stress fiber assembly 13/852 106/18722 0.00104273488553967 0.0126156419520926 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/PTK2B/PHLDB2/EVL/PIK3R1/RHOC 13 GO:0071900 regulation of protein serine/threonine kinase activity 30/852 359/18722 0.00104273933083062 0.0126156419520926 IGF2/FLT1/FGFR1/SFRP1/PRKAG2/ERBB2/TGFB1/PTK2B/APOE/CDKN1C/CSF1R/ACTB/CCNG2/TNFAIP3/INSR/SASH1/BMPR2/TIAM1/ADAM9/GBA/PKIG/MAGED1/PIK3CB/IQGAP1/PRKAR2A/HIPK3/ADAM17/IPO7/CCNE1/ERP29 30 GO:1901653 cellular response to peptide 30/852 359/18722 0.00104273933083062 0.0126156419520926 IGF2/FBN1/GDF15/PXN/LPL/CSH1/BAIAP2L1/XBP1/INSIG1/CYP11A1/RAB8B/INSR/ARHGEF2/EIF4EBP2/AP3S1/HDAC5/CAV2/ZFP36L1/PTK2/YWHAG/LRP1/KLF10/BCAR3/USO1/KLF5/TP53/ID1/PIK3R1/ERRFI1/MYO1C 30 GO:0048588 developmental cell growth 22/852 234/18722 0.00106186204273543 0.0128161910337828 FN1/ITGB1/PDLIM5/SEMA5A/CRABP2/PTPRS/SLC23A2/APOE/SEMA4C/LAMB2/BMPR2/TIAM1/CTNNB1/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/IQGAP1/CTTN/VCL/MACF1 22 GO:0003174 mitral valve development 4/852 11/18722 0.00108703052023536 0.0130573379674095 SOX4/EFNA1/BMPR2/GJA5 4 GO:0048680 positive regulation of axon regeneration 4/852 11/18722 0.00108703052023536 0.0130573379674095 PTN/FLNA/GRN/LRP1 4 GO:1903035 negative regulation of response to wounding 12/852 94/18722 0.00112764728546395 0.013512973304143 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/CLDN19/PTPRS/SMAD3/APOE/PHLDB2/UBASH3B/MDK 12 GO:0010758 regulation of macrophage chemotaxis 6/852 27/18722 0.00113553605221214 0.0135157177936789 PTK2B/CSF1R/PTK2/MIF/MAPK3/MDK 6 GO:0034377 plasma lipoprotein particle assembly 6/852 27/18722 0.00113553605221214 0.0135157177936789 APOC1/ABCA7/APOE/MFSD2A/ABCA1/ACSL3 6 GO:0043534 blood vessel endothelial cell migration 18/852 176/18722 0.00113829262207575 0.0135157177936789 FGFR1/ITGB1/PRCP/ACVRL1/GATA2/TGFB1/PTK2B/APOE/SCARB1/HSPB1/EFNA1/PLK2/HDAC5/MYH9/P2RX4/JUP/ID1/ADAM17 18 GO:0005976 polysaccharide metabolic process 13/852 107/18722 0.00113861799016885 0.0135157177936789 IGF2/IL6ST/PRKAG2/POMC/B3GNT7/TGFB1/PHKG1/GAA/INSR/PPP1CB/PYGL/B4GALT5/EXT2 13 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 8/852 47/18722 0.00115508318565016 0.0136217708608233 EPAS1/CITED2/GCN1/ATF3/EGR1/TP53/TMBIM6/ATF4 8 GO:0072583 clathrin-dependent endocytosis 8/852 47/18722 0.00115508318565016 0.0136217708608233 HIP1/CLTB/CANX/DNM2/PICALM/LMBRD1/PIK3CB/GPR107 8 GO:0031331 positive regulation of cellular catabolic process 34/852 427/18722 0.00115837828897921 0.0136217708608233 MEX3D/PTK2B/APOE/TMEM59/ENDOG/TNFAIP3/INSR/PLK2/SH3BP4/ADAM9/MTDH/GBA/PABPC1/DAPK1/PINK1/SH3D19/LDLR/ANKIB1/ZFP36L1/PAFAH1B2/PTK2/LRP1/PIK3CB/HERPUD1/RNF144B/MAPK3/RNF139/FURIN/CSNK1A1/EZR/FMR1/SH3GLB1/KCNQ1OT1/TMEM259 34 GO:0032103 positive regulation of response to external stimulus 34/852 427/18722 0.00115837828897921 0.0136217708608233 SERPINE1/IL6ST/HLA-G/FGFR1/PTN/SEMA5A/PLA2G7/LPL/SMAD3/TGFB1/PVR/PTK2B/FLNA/CCR1/GRN/PGF/CSF1R/HSPB1/SASH1/CALR/ADAM10/BMPR2/TIAM1/LAMP1/TPBG/LDLR/PTK2/LRP1/MAPK3/P2RX4/AP1G1/MDK/UBE2K/ADAM17 34 GO:0035148 tube formation 16/852 148/18722 0.00117097983314389 0.013708056159539 NOG/SFRP1/ADM/CITED2/GATA3/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/CTNNB1/SPINT1 16 GO:1903532 positive regulation of secretion by cell 25/852 282/18722 0.00117116315291114 0.013708056159539 TCF7L2/PTGES/SDC4/GATA2/CAMK2N1/TGFB1/TGFB2/INHA/SOX4/STXBP5/RAB8B/SDC1/ADAM9/TMED10/LAMP1/PINK1/ACSL4/LRP1/P2RX4/AP1G1/EZR/GOLPH3/SRI/ATP6AP1/FRMD4A 25 GO:0048638 regulation of developmental growth 28/852 330/18722 0.00120124962108526 0.0140275854824179 FN1/IGF2/PLAC8/NOG/CITED2/GDF15/SEMA5A/CRABP2/PTPRS/SLC23A2/APOE/MFSD2A/SEMA4C/WWC3/TNKS2/INSR/BMPR2/DNM2/PPIB/RTN4/EIF4G2/ATRN/LRP1/SEMA7A/CTTN/EZR/TGFBR3/MACF1 28 GO:0001704 formation of primary germ layer 14/852 121/18722 0.00121108834307684 0.0141097398858929 FN1/COL4A2/ITGA5/NOG/ITGB1/MMP2/SMAD3/COL6A1/MMP14/BMPR2/DUSP4/CTNNB1/ETS2/EXT2 14 GO:0042157 lipoprotein metabolic process 15/852 135/18722 0.00124866834630948 0.0145139671754633 NOTUM/APOC1/ZDHHC9/APOE/UGCG/APOL6/PIGT/ABCA1/WIPI1/GBA/LIPG/LDLR/LRP1/LYPLA1/GPAA1 15 GO:0050708 regulation of protein secretion 24/852 268/18722 0.00126826358273451 0.0146913519808023 SFRP1/TCF7L2/HMGN3/PAM/CAMK2N1/TGFB1/TGFB2/APOE/SOX4/P3H1/STXBP5/TIAM1/ADAM9/TMED10/ACSL4/LRP1/PPP3CA/EZR/GOLPH3/SLC16A1/SRI/DPP4/ERP29/FRMD4A 24 GO:0006979 response to oxidative stress 35/852 446/18722 0.00126976715907988 0.0146913519808023 TPM1/EPAS1/IL18BP/MMP2/P4HB/PXN/PYCR1/SLC23A2/PTK2B/APOE/PRDX4/ENDOG/MMP14/HSPB1/SOD3/TNFAIP3/GPX8/SDC1/ADAM9/CTNNB1/SCARA3/RCAN1/DAPK1/PINK1/PLEKHA1/TXN/ATRN/MAPK3/CAPN2/GPX4/PPP1R15B/TP53/ERO1A/ATF4/RBPMS 35 GO:0097305 response to alcohol 23/852 253/18722 0.00129966419240073 0.0150027749549378 HPGD/SPARC/SFRP1/GATA3/HSD3B1/TSPO/ADAM15/TGFB1/SLC23A2/PTK2B/EIF4EBP1/ABCA1/H6PD/CTNNB1/ADCY7/SDF4/DAG1/FOSB/ITPR2/JUP/GLB1/GOLPH3/TGFBR3 23 GO:0071806 protein transmembrane transport 9/852 59/18722 0.00130389359291344 0.0150171543549962 ABCA1/SEC61A1/TMED10/SEC61G/SEC62/TRAM2/TRAM1/SEC63/RTN2 9 GO:0048678 response to axon injury 11/852 83/18722 0.00131403412954283 0.0150809305959929 PTPRF/PTN/TSPO/PTPRS/FLNA/GRN/LAMB2/DAG1/LRP1/ARF4/P2RX4 11 GO:0035313 wound healing, spreading of epidermal cells 5/852 19/18722 0.00131542390853187 0.0150809305959929 ITGA5/ACVRL1/PHLDB2/RREB1/ADAM17 5 GO:0032527 protein exit from endoplasmic reticulum 8/852 48/18722 0.00133172221082382 0.0152162038867998 OS9/INSIG1/HSP90B1/HM13/HERPUD1/SEC16A/SAR1A/SEL1L 8 GO:0048880 sensory system development 31/852 381/18722 0.00133326960343309 0.0152162038867998 FLT1/MFAP5/COL4A1/FBN1/CITED2/PTN/GATA3/MFAP2/ACVRL1/SMAD3/SH3PXD2B/LPCAT1/TGFB2/MFSD2A/EPHB2/NOTCH2/LAMB2/MAN2A1/CLIC4/FAT1/BMPR2/GRHL2/CTNNB1/NAGLU/C12orf57/FBN2/BCAR3/RDH10/TUG1/ATF4/OBSL1 31 GO:0003208 cardiac ventricle morphogenesis 10/852 71/18722 0.00134524022625207 0.0152909820824597 TPM1/ENG/NOG/GATA3/TGFB1/TGFB2/SOX4/PKP2/GRHL2/TGFBR3 10 GO:0003158 endothelium development 15/852 136/18722 0.00134589808514398 0.0152909820824597 FSTL1/PTN/F11R/PLOD3/ACVRL1/PTPRS/MYADM/CLIC4/BMPR2/CTNNB1/GJA5/EZR/TJP2/VCL/ID1 15 GO:0044264 cellular polysaccharide metabolic process 12/852 96/18722 0.00135802605184818 0.0153940205381799 IGF2/IL6ST/PRKAG2/POMC/B3GNT7/PHKG1/GAA/INSR/PPP1CB/PYGL/B4GALT5/EXT2 12 GO:0006869 lipid transport 32/852 398/18722 0.00136438393610721 0.0154313356189384 PTGES/SLCO2A1/TSPO/POMC/PSAP/APOC1/ABCA7/APOE/MFSD2A/ATP11A/UGCG/SCARB1/APOL6/LIMA1/GM2A/ABCA1/NPC2/SGPP1/SCARB2/LIPG/FABP5/LRP10/LDLR/ACSL4/LRP1/RXRA/P2RX4/FURIN/HDLBP/ARL8B/GULP1/ACSL3 32 GO:0045671 negative regulation of osteoclast differentiation 6/852 28/18722 0.00139024483406568 0.015688570066934 FSTL3/FBN1/SFRP1/CTNNB1/UBASH3B/PIK3R1 6 GO:0046661 male sex differentiation 17/852 165/18722 0.00142306439002402 0.0160230046420378 FSTL3/TNFSF10/SFRP1/CITED2/GATA3/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/CTNNB1/NCOA1/PLEKHA1/RHOBTB3/TFAP2C 17 GO:1903725 regulation of phospholipid metabolic process 7/852 38/18722 0.00144605412058314 0.0162455142609262 APOC1/LPCAT1/MFSD2A/SCARB1/LDLR/CAPN2/ACSL3 7 GO:0006970 response to osmotic stress 11/852 84/18722 0.00145119861835758 0.0162669992120127 PAPPA2/TSPO/PTK2B/PKN1/ARHGEF2/ZFP36L1/EFHD1/TP53/ERRFI1/NFAT5/SERPINB6 11 GO:0002762 negative regulation of myeloid leukocyte differentiation 8/852 49/18722 0.00152917261572306 0.0170272694135711 FSTL3/FBN1/SFRP1/GATA2/INHA/CTNNB1/UBASH3B/PIK3R1 8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 8/852 49/18722 0.00152917261572306 0.0170272694135711 ENG/GDF15/ACVRL1/TGFB1/TGFB2/INHA/BMPR2/RBPMS 8 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 8/852 49/18722 0.00152917261572306 0.0170272694135711 TIMP3/SERPINE1/SFRP1/TNFAIP3/ARHGEF2/ATF3/PEA15/LGALS3 8 GO:0021915 neural tube development 16/852 152/18722 0.00155177937859257 0.0172382505277168 NOG/SFRP1/ADM/CITED2/PLOD3/SDC4/PLXNB2/TGFB1/TGFB2/SOX4/SEMA4C/TMED2/VASP/GRHL2/ZFP36L1/SPINT1 16 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 4/852 12/18722 0.0015720955676976 0.0172382505277168 SEC61A1/SEC61G/SEC62/SEC63 4 GO:0034333 adherens junction assembly 4/852 12/18722 0.0015720955676976 0.0172382505277168 ACTB/CTNNB1/ZNF703/VCL 4 GO:0043129 surfactant homeostasis 4/852 12/18722 0.0015720955676976 0.0172382505277168 EPAS1/RCN3/LPCAT1/CTSH 4 GO:0061517 macrophage proliferation 4/852 12/18722 0.0015720955676976 0.0172382505277168 CSF1R/GBA/PTK2/MAPK3 4 GO:0070572 positive regulation of neuron projection regeneration 4/852 12/18722 0.0015720955676976 0.0172382505277168 PTN/FLNA/GRN/LRP1 4 GO:1905245 regulation of aspartic-type peptidase activity 4/852 12/18722 0.0015720955676976 0.0172382505277168 GRN/EFNA1/PICALM/TMED10 4 GO:0051495 positive regulation of cytoskeleton organization 21/852 226/18722 0.00157912921124768 0.0172777333048034 TPM1/SFRP1/SDC4/SEMA5A/PXN/SMAD3/LIMCH1/PTK2B/BAIAP2L1/CDC42EP5/FLNA/VASP/NCKAP1/CDC42EP1/DSTN/EVL/CTTN/ID1/GSN/MYO1C/RHOC 21 GO:0030199 collagen fibril organization 9/852 61/18722 0.00165975659983796 0.0180812878073257 FKBP10/MMP11/PLOD3/TGFB2/SERPINH1/P3H4/BMP1/COLGALT1/P4HA1 9 GO:0060998 regulation of dendritic spine development 9/852 61/18722 0.00165975659983796 0.0180812878073257 PTPRS/APOE/SRGAP2C/EFNA1/PLK2/TIAM1/MAPK6/EIF4G2/FMR1 9 GO:0003209 cardiac atrium morphogenesis 6/852 29/18722 0.00168629235798317 0.018173681879506 ENG/NOG/TGFB2/SOX4/NOTCH2/BMPR2 6 GO:0006656 phosphatidylcholine biosynthetic process 6/852 29/18722 0.00168629235798317 0.018173681879506 LPCAT1/MFSD2A/FABP5/SLC44A2/CAPN2/ACSL3 6 GO:0010955 negative regulation of protein processing 6/852 29/18722 0.00168629235798317 0.018173681879506 SERPINE2/SERPINE1/IL1R2/TMEM59/CTSZ/XIAP 6 GO:0048679 regulation of axon regeneration 6/852 29/18722 0.00168629235798317 0.018173681879506 PTPRF/PTN/PTPRS/FLNA/GRN/LRP1 6 GO:1903318 negative regulation of protein maturation 6/852 29/18722 0.00168629235798317 0.018173681879506 SERPINE2/SERPINE1/IL1R2/TMEM59/CTSZ/XIAP 6 GO:0043010 camera-type eye development 27/852 322/18722 0.00172752861847796 0.0185783152495717 FLT1/COL4A1/FBN1/CITED2/PTN/GATA3/ACVRL1/SMAD3/LPCAT1/TGFB2/MFSD2A/EPHB2/NOTCH2/LAMB2/MAN2A1/CLIC4/FAT1/BMPR2/GRHL2/CTNNB1/NAGLU/C12orf57/FBN2/BCAR3/RDH10/ATF4/OBSL1 27 GO:0060688 regulation of morphogenesis of a branching structure 8/852 50/18722 0.00174911944521519 0.0187704012105928 NOG/SFRP1/NTN4/CTNNB1/RTN4/MAGED1/BTBD7/MDK 8 GO:0030856 regulation of epithelial cell differentiation 16/852 154/18722 0.00177818281921071 0.019001261420568 SERPINE1/GATA3/F11R/ACVRL1/WWTR1/GRHL2/SGPP1/CTNNB1/ZFP36L1/MYCL/MYCN/SRSF6/VCL/ID1/ERRFI1/GRHL1 16 GO:0050770 regulation of axonogenesis 16/852 154/18722 0.00177818281921071 0.019001261420568 FN1/SEMA5A/PLXNB2/CRABP2/METRN/PTPRS/EPHB2/SEMA4C/EFNA1/BMPR2/TIAM1/RTN4/EIF4G2/LRP1/SEMA7A/MACF1 16 GO:0031099 regeneration 19/852 198/18722 0.00178640879369897 0.0190487191921333 PTPRF/ADM/PTN/CD9/TSPO/PTPRS/ADAM15/FLNA/GRN/PGF/LAMB2/DAG1/LRP1/IGF2R/PPP3CA/KLF5/MDK/PTPN3/TGFBR3 19 GO:0010498 proteasomal protein catabolic process 37/852 490/18722 0.00184854060515324 0.0196664989739409 IFI27/RCN3/WWTR1/APOE/OS9/WFS1/PLK2/CANX/CALR/HSP90B1/CTNNB1/GBA/PINK1/HM13/ANKIB1/LTN1/FAM8A1/ASCC2/HERPUD1/RNF144B/MAN1B1/RNF139/ANKRD9/SEL1L/CSNK1A1/DNAJC10/DDB1/DDI2/STT3B/AMFR/EDEM3/UBE2K/FMR1/UBE2A/PCBP2/SDF2L1/TMEM259 37 GO:0003151 outflow tract morphogenesis 10/852 74/18722 0.00185215984773455 0.0196664989739409 ENG/NOG/CITED2/TGFB2/PARVA/BMPR2/DHRS3/CTNNB1/GJA5/TGFBR3 10 GO:0009311 oligosaccharide metabolic process 9/852 62/18722 0.00186475859685004 0.0197585895114657 HEXB/GAA/B4GALT1/GM2A/MGAT2/ST3GAL6/MAN1B1/MOGS/NEU1 9 GO:0008544 epidermis development 27/852 324/18722 0.00188752381996026 0.0199577886257562 COL17A1/FLNB/SLC4A7/CST6/PLOD3/CRABP2/PLOD1/TGFB2/UGCG/FOSL2/PALLD/CLIC4/GRHL2/SGPP1/ADAM9/CTNNB1/FABP5/LAMA5/ZFP36L1/OPN3/MYCL/MYO6/MYCN/SRSF6/KRT10/ERRFI1/GRHL1 27 GO:1903364 positive regulation of cellular protein catabolic process 16/852 155/18722 0.00190137339319944 0.0200620802682868 PTK2B/APOE/TNFAIP3/PLK2/GBA/LDLR/ANKIB1/PTK2/LRP1/HERPUD1/RNF144B/RNF139/CSNK1A1/EZR/FMR1/TMEM259 16 GO:0070663 regulation of leukocyte proliferation 22/852 245/18722 0.00191410898712545 0.0201542061343147 IGF2/EBI3/IL6ST/HLA-G/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/CSF1R/TNFAIP3/PKN1/CBLB/CD320/CTNNB1/BST2/PTK2/LGALS3/MIF/MAPK3/NDFIP1 22 GO:0006641 triglyceride metabolic process 12/852 100/18722 0.00193597249759677 0.0202994782925094 APOC1/LPL/APOE/MFSD2A/SCARB1/INSIG1/MGLL/LIPG/LDLR/ACSL4/SEL1L/CTDNEP1 12 GO:0110020 regulation of actomyosin structure organization 12/852 100/18722 0.00193597249759677 0.0202994782925094 TPM1/SFRP1/F11R/SDC4/ASAP3/PXN/SMAD3/LIMCH1/PHLDB2/EVL/PIK3R1/RHOC 12 GO:0030204 chondroitin sulfate metabolic process 6/852 30/18722 0.00202782672160705 0.0210434059584501 BGN/CHPF/UGDH/DSEL/CHPF2/DSE 6 GO:0034368 protein-lipid complex remodeling 6/852 30/18722 0.00202782672160705 0.0210434059584501 APOC1/PLA2G7/LPL/APOE/SCARB1/LIPG 6 GO:0034369 plasma lipoprotein particle remodeling 6/852 30/18722 0.00202782672160705 0.0210434059584501 APOC1/PLA2G7/LPL/APOE/SCARB1/LIPG 6 GO:0044788 modulation by host of viral process 6/852 30/18722 0.00202782672160705 0.0210434059584501 IFI27/APOE/PPIB/CAV2/IGF2R/FMR1 6 GO:0061384 heart trabecula morphogenesis 6/852 30/18722 0.00202782672160705 0.0210434059584501 ENG/NOG/ADAMTS1/TGFB2/FHL2/TGFBR3 6 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/852 114/18722 0.00203707111021598 0.0210958413533272 ENG/CITED2/GDF15/ACVRL1/TGFB1/TGFB2/INHA/CDKN1C/NOTCH2/BMPR2/ADAM17/TGFBR3/RBPMS 13 GO:0035303 regulation of dephosphorylation 14/852 128/18722 0.00207807528867846 0.0214762893797098 MGAT5/ITGA1/SMAD3/TGFB1/NUAK1/TGFB2/HSP90B1/GBA/RCAN1/PINK1/LGALS3/PPP1R15B/SYMPK/CAMTA1 14 GO:0009612 response to mechanical stimulus 20/852 216/18722 0.00210287023718548 0.0216880039011363 SERPINE2/ENG/CITED2/PTN/F11R/PTK2B/KCNJ2/ENDOG/MMP14/CNN2/CTNNB1/DAG1/PTK2/FOSB/MBD2/MAPK3/SLC1A3/MDK/JUP/GSN 20 GO:0008217 regulation of blood pressure 18/852 186/18722 0.00212108844282256 0.0218311618256154 TAC3/TPM1/LVRN/ADM/PRCP/F11R/ACVRL1/POMC/SMAD3/CAMK2N1/EDNRB/NAV2/BMPR2/GJA5/CTSZ/ERAP1/P2RX4/EXT2 18 GO:0022411 cellular component disassembly 34/852 443/18722 0.00213286877180896 0.0218786798032344 MMP11/MMP2/TSPO/SEMA5A/DNASE1L3/IQSEC1/ADAM15/SH3PXD2B/CAPG/TGFB1/MAPRE2/ENDOG/LIMA1/MMP14/INSR/ARHGEF2/ADAM10/WIPI1/GBA/PINK1/SH3GL1/DSTN/LRP1/LAMC1/CTTN/CCSAP/FURIN/MICAL3/TP53/PIK3R1/GSN/LAMP2/CTDNEP1/DPP4 34 GO:0046514 ceramide catabolic process 5/852 21/18722 0.00213439932115798 0.0218786798032344 HEXB/GM2A/GBA/HEXA/NEU1 5 GO:0006983 ER overload response 4/852 13/18722 0.00218953592955546 0.022128382195688 WFS1/PPP1R15B/TP53/TMCO1 4 GO:0032352 positive regulation of hormone metabolic process 4/852 13/18722 0.00218953592955546 0.022128382195688 ADM/GATA3/EGR1/RDH10 4 GO:0033700 phospholipid efflux 4/852 13/18722 0.00218953592955546 0.022128382195688 APOC1/ABCA7/APOE/ABCA1 4 GO:0044794 positive regulation by host of viral process 4/852 13/18722 0.00218953592955546 0.022128382195688 APOE/PPIB/CAV2/IGF2R 4 GO:0061000 negative regulation of dendritic spine development 4/852 13/18722 0.00218953592955546 0.022128382195688 PTPRS/SRGAP2C/EFNA1/PLK2 4 GO:0061744 motor behavior 4/852 13/18722 0.00218953592955546 0.022128382195688 MFSD2A/GBA/C12orf57/DPP4 4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/852 13/18722 0.00218953592955546 0.022128382195688 TIMP3/SFRP1/ATF3/PEA15 4 GO:0071675 regulation of mononuclear cell migration 13/852 115/18722 0.00220344335612858 0.0222243094416736 SERPINE1/JAM2/PLA2G7/PTK2B/CCR1/CSF1R/CALR/ADAM10/PTK2/LGALS3/MAPK3/MDK/ADAM17 13 GO:0009913 epidermal cell differentiation 19/852 202/18722 0.00224626133952779 0.0226108666436867 FLNB/SLC4A7/UGCG/FOSL2/PALLD/CLIC4/GRHL2/SGPP1/ADAM9/CTNNB1/ZFP36L1/OPN3/MYCL/MYO6/MYCN/SRSF6/KRT10/ERRFI1/GRHL1 19 GO:0032868 response to insulin 23/852 264/18722 0.00226181845192916 0.0226941899744906 IGF2/TNFSF10/ADM/LPL/BAIAP2L1/XBP1/INSIG1/RAB8B/INSR/EIF4EBP2/AP3S1/HDAC5/CAV2/ZFP36L1/EGR1/YWHAG/BCAR3/USO1/SRSF6/INPPL1/PIK3R1/ERRFI1/MYO1C 23 GO:0051496 positive regulation of stress fiber assembly 8/852 52/18722 0.00226355719594562 0.0226941899744906 TPM1/SFRP1/SDC4/PXN/SMAD3/LIMCH1/EVL/RHOC 8 GO:0001953 negative regulation of cell-matrix adhesion 7/852 41/18722 0.00228879318801744 0.0228108833966174 SERPINE1/ACVRL1/ADAM15/PHLDB2/MMP14/LRP1/PIK3R1 7 GO:0050892 intestinal absorption 7/852 41/18722 0.00228879318801744 0.0228108833966174 F11R/UGCG/SCARB1/LIMA1/LDLR/EZR/TJP2 7 GO:1905314 semi-lunar valve development 7/852 41/18722 0.00228879318801744 0.0228108833966174 GATA3/TGFB1/TGFB2/NOTCH2/EFNA1/BMPR2/GJA5 7 GO:0007163 establishment or maintenance of cell polarity 20/852 218/18722 0.0023431005461351 0.0233059783571105 ITGB1/GATA3/PTK2B/PARVA/ACTB/CLIC4/FAT1/RHOD/AMOTL2/MYH9/PTK2/ARF4/RHOBTB3/GSN/GOLPH3/WEE1/RHOC/MAP4/RND3/FRMD4A 20 GO:0014065 phosphatidylinositol 3-kinase signaling 15/852 144/18722 0.00237721237770228 0.0235986388500504 FN1/SERPINE2/FLT1/FGFR1/GATA3/ERBB2/TGFB2/INSR/PLEKHA1/ZFP36L1/PTK2/ERBB3/PIK3CB/MYDGF/PIK3R1 15 GO:0015918 sterol transport 14/852 130/18722 0.00240370963980256 0.023814705939225 TSPO/APOC1/ABCA7/APOE/SCARB1/LIMA1/ABCA1/NPC2/LIPG/LDLR/LRP1/RXRA/FURIN/ARL8B 14 GO:0065005 protein-lipid complex assembly 6/852 31/18722 0.00241911854184449 0.0239202821632679 APOC1/ABCA7/APOE/MFSD2A/ABCA1/ACSL3 6 GO:0070371 ERK1 and ERK2 cascade 27/852 330/18722 0.00244600393118513 0.0241387015404995 FN1/TIMP3/FBLN1/ERBB2/ABCA7/CAMK2N1/TGFB1/PTK2B/APOE/EPHB2/CCR1/NOTCH2/CSF1R/ATF3/TIAM1/DUSP4/TPBG/ZFP36L1/LRP1/MIF/SEMA7A/MAPK3/CTSH/NPTN/EZR/ERRFI1/ATP6AP1 27 GO:0006605 protein targeting 26/852 314/18722 0.0024756570259483 0.0243835260500936 TSPO/ERBB2/ZDHHC9/RHOU/OS9/RAB8B/SCARB2/LMAN1/SEC61A1/SSR3/NUCB1/PINK1/SEC61G/YWHAG/HERPUD1/SEC62/TRAM2/SSR1/TRAM1/SPCS3/LAMP2/SEC63/MYO1C/SH3GLB1/SSR2/SIL1 26 GO:0097581 lamellipodium organization 11/852 90/18722 0.00254159503265757 0.0249840777331358 ITGB1/SRGAP2/RHOD/NCKAP1/DNM2/CTTN/ARHGEF7/VCL/PIK3R1/RREB1/GOLPH3 11 GO:0022407 regulation of cell-cell adhesion 34/852 448/18722 0.00255590990867856 0.0250352584524929 SERPINE2/FSTL3/IGF2/EBI3/IL6ST/HLA-G/ADAM19/CITED2/GATA3/CD9/F11R/SDC4/ERBB2/FXYD5/CD276/TGFB1/EFNB1/SLC7A1/SOX4/MYADM/XBP1/PLPP3/MYO10/CBLB/UBASH3B/JAK1/PTK2/LGALS3/ZNF703/NDFIP1/MDK/HSPH1/NFAT5/DPP4 34 GO:0043620 regulation of DNA-templated transcription in response to stress 8/852 53/18722 0.00256172424061868 0.0250352584524929 EPAS1/CITED2/GCN1/ATF3/EGR1/TP53/TMBIM6/ATF4 8 GO:0050819 negative regulation of coagulation 8/852 53/18722 0.00256172424061868 0.0250352584524929 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/PROCR/APOE/UBASH3B 8 GO:0006612 protein targeting to membrane 14/852 131/18722 0.00258165357625819 0.0251811287777276 ERBB2/ZDHHC9/RAB8B/SEC61A1/SSR3/SEC61G/SEC62/TRAM2/SSR1/TRAM1/SEC63/MYO1C/SSR2/SIL1 14 GO:0045682 regulation of epidermis development 9/852 65/18722 0.00260351616007869 0.0252963259337376 GRHL2/SGPP1/ZFP36L1/MYCL/MYCN/SRSF6/KRT10/ERRFI1/GRHL1 9 GO:0071677 positive regulation of mononuclear cell migration 9/852 65/18722 0.00260351616007869 0.0252963259337376 SERPINE1/JAM2/PLA2G7/PTK2B/CCR1/CALR/ADAM10/LGALS3/ADAM17 9 GO:0035019 somatic stem cell population maintenance 7/852 42/18722 0.00264059024572688 0.0254996318170409 ASCL2/NOG/SFRP1/GATA2/SOX4/TAF5L/KLF10 7 GO:0045773 positive regulation of axon extension 7/852 42/18722 0.00264059024572688 0.0254996318170409 FN1/SEMA5A/BMPR2/EIF4G2/LRP1/SEMA7A/MACF1 7 GO:0060965 negative regulation of gene silencing by miRNA 5/852 22/18722 0.00265990596144377 0.0254996318170409 TGFB1/NCOR2/PPP3CA/TP53/KCNQ1OT1 5 GO:0061042 vascular wound healing 5/852 22/18722 0.00265990596144377 0.0254996318170409 SERPINE1/MCAM/GATA2/XBP1/TNFAIP3 5 GO:0071404 cellular response to low-density lipoprotein particle stimulus 5/852 22/18722 0.00265990596144377 0.0254996318170409 ITGB1/CD9/LPL/ABCA1/LDLR 5 GO:0072574 hepatocyte proliferation 5/852 22/18722 0.00265990596144377 0.0254996318170409 PTN/XBP1/NOTCH2/TNFAIP3/MDK 5 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 5/852 22/18722 0.00265990596144377 0.0254996318170409 PTN/XBP1/NOTCH2/TNFAIP3/MDK 5 GO:0016050 vesicle organization 25/852 300/18722 0.0027261115253736 0.0260846374661698 SERPINE2/SDC4/SEC24D/SEC23A/TMED2/INSIG1/RAB8B/ABCA1/SCARB2/SDC1/SEC24A/SEC31A/SNAP23/PICALM/TMED10/CAV2/SAR1A/TMED9/USO1/ARL8B/AP1G1/ARFGAP3/SEC22B/YIPF5/GOLPH3 25 GO:0061045 negative regulation of wound healing 10/852 78/18722 0.00275693868618449 0.0263295491604678 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/CLDN19/SMAD3/APOE/PHLDB2/UBASH3B 10 GO:0014033 neural crest cell differentiation 11/852 91/18722 0.00277508763951321 0.0264526819880113 FN1/SFRP1/CITED2/SEMA5A/EFNB1/EDNRB/SEMA4C/LAMA5/SEMA7A/MAPK3/RDH10 11 GO:0016311 dephosphorylation 32/852 417/18722 0.00284273079505918 0.0270462459197218 PTPRF/MGAT5/ITGA1/PTPRS/SMAD3/TGFB1/NUAK1/TGFB2/NT5DC2/PLPP3/TNS3/HSP90B1/SGPP1/DUSP4/GBA/UBASH3B/RCAN1/PINK1/PPP1CB/LGALS3/CTDSP1/PPP3CA/SSH2/PPP1R15B/INPPL1/PPP2R5E/SYMPK/PTPN3/CAMTA1/PTP4A1/CTDNEP1/IMPA2 32 GO:0007435 salivary gland morphogenesis 6/852 32/18722 0.00286454204574446 0.0271000754064509 TGFB1/TGFB2/NTN4/DAG1/LAMA5/BTBD7 6 GO:0034367 protein-containing complex remodeling 6/852 32/18722 0.00286454204574446 0.0271000754064509 APOC1/PLA2G7/LPL/APOE/SCARB1/LIPG 6 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 6/852 32/18722 0.00286454204574446 0.0271000754064509 XBP1/WFS1/HERPUD1/SERINC3/TMBIM6/ERP29 6 GO:0014015 positive regulation of gliogenesis 9/852 66/18722 0.00289556096397538 0.0273421357067319 SERPINE2/IL6ST/PTN/TSPO/TGFB1/DAG1/MDK/RHEB/SPINT1 9 GO:0001889 liver development 15/852 147/18722 0.00290341501066551 0.0273649583308605 CITED2/PTN/SMAD3/XBP1/NOTCH2/MAN2A1/TNFAIP3/PRKCSH/IGF2R/LSR/MDK/PTPN3/KRT18/SEC63/TGFBR3 15 GO:0006047 UDP-N-acetylglucosamine metabolic process 4/852 14/18722 0.0029558266449377 0.0276005111390936 SLC35A3/MGAT1/GFPT1/PGM3 4 GO:0006465 signal peptide processing 4/852 14/18722 0.0029558266449377 0.0276005111390936 HM13/CLN5/FURIN/SPCS3 4 GO:0010867 positive regulation of triglyceride biosynthetic process 4/852 14/18722 0.0029558266449377 0.0276005111390936 MFSD2A/SCARB1/LDLR/CTDNEP1 4 GO:0034111 negative regulation of homotypic cell-cell adhesion 4/852 14/18722 0.0029558266449377 0.0276005111390936 SERPINE2/CD9/UBASH3B/ZNF703 4 GO:0048875 chemical homeostasis within a tissue 4/852 14/18722 0.0029558266449377 0.0276005111390936 EPAS1/RCN3/LPCAT1/CTSH 4 GO:0030282 bone mineralization 13/852 119/18722 0.00298445947476391 0.0278162676601607 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2/KLF10/ATF4 13 GO:0043405 regulation of MAP kinase activity 17/852 177/18722 0.00300770348825362 0.0279810936347144 FLT1/FGFR1/SFRP1/ERBB2/TGFB1/PTK2B/APOE/INSR/SASH1/TIAM1/ADAM9/GBA/MAGED1/PIK3CB/IQGAP1/HIPK3/ERP29 17 GO:0006446 regulation of translational initiation 10/852 79/18722 0.00303081982132224 0.0280557750271205 HSPB1/TMED2/EIF4EBP1/EIF4EBP2/EIF4G2/PPP1R15B/FMR1/ATF4/EIF4B/DNAJC3 10 GO:0014014 negative regulation of gliogenesis 7/852 43/18722 0.00303245412572095 0.0280557750271205 ASCL2/NOG/PTN/TSPO/CTNNB1/LDLR/MYCN 7 GO:0016266 O-glycan processing 7/852 43/18722 0.00303245412572095 0.0280557750271205 B3GNT7/GALNT7/GALNT6/GALNT3/GALNT2/B4GALT5/GALNT1 7 GO:0051384 response to glucocorticoid 15/852 148/18722 0.00309880243670178 0.0286170140622387 PAPPA/SPARC/ADM/HSD3B1/PAM/SMYD3/FBXO32/SDC1/ADAM9/GBA/ZFP36L1/FOSB/MDK/GLB1/ERRFI1 15 GO:0019882 antigen processing and presentation 12/852 106/18722 0.00316768711860737 0.0291769937617695 HLA-G/CTSL/TAP1/TAPBP/RAB8B/CALR/GBA/DNM2/CTSF/ERAP1/ARL8B/CTSH 12 GO:0032102 negative regulation of response to external stimulus 32/852 420/18722 0.00317103429121556 0.0291769937617695 SERPINE2/HTRA1/SERPINE1/HLA-G/SERPING1/TFPI/GATA3/CD9/CLDN19/SEMA5A/PTPRS/SMAD3/APOE/GRN/SEMA4C/PHLDB2/ISG15/TNFAIP3/PLK2/NUCB2/GBA/UBASH3B/STAT2/LDLR/MIF/SEMA7A/FURIN/NDFIP1/SEC14L1/MDK/PCBP2/DPP4 32 GO:0071496 cellular response to external stimulus 26/852 320/18722 0.00319823190399415 0.029373542286136 AOC1/ENG/SFRP1/PTN/F11R/PRKAG2/LPL/NUAK1/MFSD2A/KCNJ2/XBP1/GCN1/CNN2/ATF3/BMPR2/DAP/WIPI1/GBA/NCOA1/DAG1/MAPK3/KLF10/TP53/LAMP2/ATF4/SH3GLB1 26 GO:0048593 camera-type eye morphogenesis 13/852 120/18722 0.00321139471924349 0.029400691458346 CITED2/PTN/MFSD2A/EPHB2/NOTCH2/MAN2A1/FAT1/CTNNB1/NAGLU/C12orf57/BCAR3/ATF4/OBSL1 13 GO:0050435 amyloid-beta metabolic process 9/852 67/18722 0.0032128711110849 0.029400691458346 ABCA7/APOE/EFNA1/ADAM10/PICALM/RTN4/TMED10/NCSTN/RTN2 9 GO:0003179 heart valve morphogenesis 8/852 55/18722 0.00324955697833187 0.0295750818660838 GATA3/TGFB1/TGFB2/SOX4/NOTCH2/EFNA1/BMPR2/GJA5 8 GO:0003229 ventricular cardiac muscle tissue development 8/852 55/18722 0.00324955697833187 0.0295750818660838 TPM1/ENG/NOG/TGFB1/TGFB2/PKP2/DSG2/TGFBR3 8 GO:0098900 regulation of action potential 8/852 55/18722 0.00324955697833187 0.0295750818660838 KCNJ2/FLNA/PKP2/GBA/DSG2/GJA5/JUP/FMR1 8 GO:0003283 atrial septum development 5/852 23/18722 0.00327310008229489 0.029575426775925 TGFB2/SOX4/NOTCH2/BMPR2/GJA5 5 GO:0030325 adrenal gland development 5/852 23/18722 0.00327310008229489 0.029575426775925 FSTL3/CITED2/TSPO/SMAD3/MDK 5 GO:0060396 growth hormone receptor signaling pathway 5/852 23/18722 0.00327310008229489 0.029575426775925 GDF15/PXN/CSH1/PTK2/PIK3R1 5 GO:0072576 liver morphogenesis 5/852 23/18722 0.00327310008229489 0.029575426775925 PTN/XBP1/NOTCH2/TNFAIP3/MDK 5 GO:0060349 bone morphogenesis 11/852 93/18722 0.00329390332364194 0.0297100634908421 PAPPA2/CITED2/COL27A1/SERPINH1/MMP14/INSIG1/LTBP3/BMPR2/DHRS3/INPPL1/EXT2 11 GO:0045834 positive regulation of lipid metabolic process 15/852 149/18722 0.00330487883413326 0.029755733760631 FLT1/ADM/APOC1/TGFB1/PTK2B/APOE/MFSD2A/SCARB1/LDLR/DGKZ/PTK2/CAPN2/RDH10/CTDNEP1/ACSL3 15 GO:0003382 epithelial cell morphogenesis 6/852 33/18722 0.00336855564801723 0.0301671540506596 FLNB/PLOD3/PALLD/CLIC4/FAT1/GRHL2 6 GO:0070570 regulation of neuron projection regeneration 6/852 33/18722 0.00336855564801723 0.0301671540506596 PTPRF/PTN/PTPRS/FLNA/GRN/LRP1 6 GO:1902992 negative regulation of amyloid precursor protein catabolic process 6/852 33/18722 0.00336855564801723 0.0301671540506596 ABCA7/APOE/PICALM/RTN4/TMED10/RTN2 6 GO:0061008 hepaticobiliary system development 15/852 150/18722 0.00352207611044311 0.031485984127638 CITED2/PTN/SMAD3/XBP1/NOTCH2/MAN2A1/TNFAIP3/PRKCSH/IGF2R/LSR/MDK/PTPN3/KRT18/SEC63/TGFBR3 15 GO:0010812 negative regulation of cell-substrate adhesion 9/852 68/18722 0.00355692318854957 0.0317411248368262 SERPINE1/FBLN1/ACVRL1/ADAM15/PHLDB2/MMP14/LRP1/ACTN4/PIK3R1 9 GO:0043409 negative regulation of MAPK cascade 17/852 180/18722 0.00357716222249693 0.0317868790199211 TIMP3/SFRP1/FBLN1/ABCA7/CAMK2N1/APOE/EPHB2/EFNA1/ATF3/DUSP4/GBA/DAG1/PINK1/PIK3CB/HIPK3/EZR/ERRFI1 17 GO:0071375 cellular response to peptide hormone stimulus 24/852 290/18722 0.00357888824642508 0.0317868790199211 IGF2/FBN1/GDF15/PXN/LPL/CSH1/BAIAP2L1/XBP1/INSIG1/CYP11A1/RAB8B/INSR/EIF4EBP2/AP3S1/HDAC5/CAV2/ZFP36L1/PTK2/YWHAG/BCAR3/USO1/PIK3R1/ERRFI1/MYO1C 24 GO:1902414 protein localization to cell junction 11/852 94/18722 0.00358099749737637 0.0317868790199211 F11R/GPC4/FLNA/ACTB/HSPB1/ADAM10/DAG1/JAK1/LSR/TJP2/VCL 11 GO:0006687 glycosphingolipid metabolic process 8/852 56/18722 0.00364321325133385 0.032002852232356 HEXB/UGCG/GM2A/GBA/HEXA/B4GALT5/GLB1/NEU1 8 GO:0031529 ruffle organization 8/852 56/18722 0.00364321325133385 0.032002852232356 TPM1/AIF1L/LIMA1/CSF1R/PLEKHA1/EVL/INPPL1/EPS8L2 8 GO:0045599 negative regulation of fat cell differentiation 8/852 56/18722 0.00364321325133385 0.032002852232356 GATA3/MMP11/GATA2/SMAD3/WWTR1/TGFB1/INSIG1/TRIO 8 GO:0014032 neural crest cell development 10/852 81/18722 0.00364347989849791 0.032002852232356 FN1/CITED2/SEMA5A/EFNB1/EDNRB/SEMA4C/LAMA5/SEMA7A/MAPK3/RDH10 10 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 10/852 81/18722 0.00364347989849791 0.032002852232356 HTRA1/HTRA4/LTBP1/FBN1/DNM2/CAV2/FBN2/TP53/ADAM17/TGFBR3 10 GO:0048708 astrocyte differentiation 10/852 81/18722 0.00364347989849791 0.032002852232356 SERPINE2/IL6ST/NOG/GCM1/GRN/LAMB2/LDLR/LRP1/MAPK3/MYCN 10 GO:0071456 cellular response to hypoxia 15/852 151/18722 0.00375083566558593 0.0328758953867184 EGLN3/EPAS1/SFRP1/CITED2/PTN/P4HB/ENDOG/EIF4EBP1/PINK1/ZFP36L1/EGR1/NDRG1/TP53/ERO1A/TMBIM6 15 GO:0043112 receptor metabolic process 16/852 166/18722 0.00379452509390888 0.0328758953867184 ITGB1/ADM/CD9/TGFB1/APOE/CD63/ANKRD13A/INSR/DNM2/PICALM/LMBRD1/LRP1/FURIN/EZR/FMR1/SH3GLB1 16 GO:0010763 positive regulation of fibroblast migration 4/852 15/18722 0.00388689808969722 0.0328758953867184 ITGB1/TGFB1/PTK2/ARHGEF7 4 GO:0031269 pseudopodium assembly 4/852 15/18722 0.00388689808969722 0.0328758953867184 CDC42EP5/SRGAP2C/SRGAP2/CDC42EP1 4 GO:0032488 Cdc42 protein signal transduction 4/852 15/18722 0.00388689808969722 0.0328758953867184 APOE/RALBP1/RHOU/ABCA1 4 GO:0033599 regulation of mammary gland epithelial cell proliferation 4/852 15/18722 0.00388689808969722 0.0328758953867184 GATA3/RTN4/ZNF703/RREB1 4 GO:0034384 high-density lipoprotein particle clearance 4/852 15/18722 0.00388689808969722 0.0328758953867184 APOE/SCARB1/LIPG/LDLR 4 GO:0042159 lipoprotein catabolic process 4/852 15/18722 0.00388689808969722 0.0328758953867184 NOTUM/APOE/LDLR/LYPLA1 4 GO:0060413 atrial septum morphogenesis 4/852 15/18722 0.00388689808969722 0.0328758953867184 TGFB2/SOX4/NOTCH2/BMPR2 4 GO:0086069 bundle of His cell to Purkinje myocyte communication 4/852 15/18722 0.00388689808969722 0.0328758953867184 PKP2/DSG2/GJA5/JUP 4 GO:0090594 inflammatory response to wounding 4/852 15/18722 0.00388689808969722 0.0328758953867184 TIMP1/TGFB1/GRN/MDK 4 GO:1903729 regulation of plasma membrane organization 4/852 15/18722 0.00388689808969722 0.0328758953867184 DNM2/MYH9/GSN/SH3GLB1 4 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 4/852 15/18722 0.00388689808969722 0.0328758953867184 TGFB1/NCOR2/PPP3CA/TP53 4 GO:1904380 endoplasmic reticulum mannose trimming 4/852 15/18722 0.00388689808969722 0.0328758953867184 MAN1B1/RNF139/AMFR/EDEM3 4 GO:1905146 lysosomal protein catabolic process 4/852 15/18722 0.00388689808969722 0.0328758953867184 GBA/LDLR/LRP1/LAMP2 4 GO:2000345 regulation of hepatocyte proliferation 4/852 15/18722 0.00388689808969722 0.0328758953867184 PTN/XBP1/TNFAIP3/MDK 4 GO:2001028 positive regulation of endothelial cell chemotaxis 4/852 15/18722 0.00388689808969722 0.0328758953867184 FGFR1/SEMA5A/HSPB1/P2RX4 4 GO:0018108 peptidyl-tyrosine phosphorylation 29/852 375/18722 0.00391729338514138 0.0328758953867184 IGF2/FLT1/IL6ST/ITGA5/FGFR1/SFRP1/SH3BP5/ERBB2/CSH1/TGFB1/GPRC5A/PTK2B/EPHB2/CSF1R/EFNA1/INSR/ARHGEF2/CBLB/JAK1/PTK2/ERBB3/MIF/MAPK3/IQGAP1/HIPK3/TP53/WEE1/ERRFI1/ADAM17 29 GO:0046486 glycerolipid metabolic process 30/852 392/18722 0.00393302890194101 0.0328758953867184 APOC1/PLA2G7/LPL/LPCAT1/GDPD3/APOE/MFSD2A/SCARB1/CSF1R/PIGT/IPMK/INSIG1/MGLL/LIPG/FABP5/LDLR/ACSL4/DGKZ/PIK3CB/SLC44A2/CAPN2/SEL1L/SERINC3/INPPL1/PIK3R1/CTDNEP1/ACSL3/GPAA1/IMPA2/SERINC2 30 GO:0007431 salivary gland development 6/852 34/18722 0.00393568219548338 0.0328758953867184 TGFB1/TGFB2/NTN4/DAG1/LAMA5/BTBD7 6 GO:0035909 aorta morphogenesis 6/852 34/18722 0.00393568219548338 0.0328758953867184 ENG/FKBP10/ACVRL1/TGFB2/SOX4/LRP1 6 GO:0055094 response to lipoprotein particle 6/852 34/18722 0.00393568219548338 0.0328758953867184 ITGB1/CD9/LPL/APOE/ABCA1/LDLR 6 GO:0086004 regulation of cardiac muscle cell contraction 6/852 34/18722 0.00393568219548338 0.0328758953867184 KCNJ2/PKP2/DSG2/GJA5/JUP/SRI 6 GO:2000352 negative regulation of endothelial cell apoptotic process 6/852 34/18722 0.00393568219548338 0.0328758953867184 SERPINE1/GATA3/SEMA5A/GATA2/ANGPTL4/TNFAIP3 6 GO:1903829 positive regulation of cellular protein localization 23/852 276/18722 0.00394291552662528 0.0328758953867184 ITGB1/PTN/ERBB2/SMAD3/WWTR1/ABCA7/TGFB1/ARHGEF16/EPHB2/FLNA/RHOU/RTN4/PINK1/LRP1/LGALS3/IQGAP1/NPTN/EZR/JUP/PIK3R1/MYO1C/ACSL3/SH3GLB1 23 GO:0006903 vesicle targeting 7/852 45/18722 0.00394794632265991 0.0328758953867184 TMED2/WIPI1/SNAP23/TMED10/SAR1A/TMED9/ARFGAP3 7 GO:0035307 positive regulation of protein dephosphorylation 7/852 45/18722 0.00394794632265991 0.0328758953867184 ITGA1/TGFB1/GBA/PINK1/PPP1R15B/SYMPK/CAMTA1 7 GO:0035987 endodermal cell differentiation 7/852 45/18722 0.00394794632265991 0.0328758953867184 FN1/COL4A2/ITGA5/MMP2/COL6A1/MMP14/CTNNB1 7 GO:0090150 establishment of protein localization to membrane 22/852 260/18722 0.00396183337913242 0.0328758953867184 ERBB2/ZDHHC9/RAB8B/SEC61A1/SSR3/SEC61G/SEC16A/SEC62/TRAM2/SSR1/TRAM1/LYPLA1/GOLPH3/KRT18/SEC63/MYO1C/EMC10/GORASP2/ACSL3/MACF1/SSR2/SIL1 22 GO:0003231 cardiac ventricle development 13/852 123/18722 0.00397770547357252 0.0328758953867184 TPM1/ENG/NOG/CITED2/GATA3/TGFB1/TGFB2/SOX4/PKP2/BMPR2/GRHL2/GJA5/TGFBR3 13 GO:0016486 peptide hormone processing 5/852 24/18722 0.0039817646414607 0.0328758953867184 PCSK1N/CTSL/PCSK6/CTSZ/FURIN 5 GO:0021801 cerebral cortex radial glia-guided migration 5/852 24/18722 0.0039817646414607 0.0328758953867184 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0022030 telencephalon glial cell migration 5/852 24/18722 0.0039817646414607 0.0328758953867184 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0060149 negative regulation of posttranscriptional gene silencing 5/852 24/18722 0.0039817646414607 0.0328758953867184 TGFB1/NCOR2/PPP3CA/TP53/KCNQ1OT1 5 GO:0060967 negative regulation of gene silencing by RNA 5/852 24/18722 0.0039817646414607 0.0328758953867184 TGFB1/NCOR2/PPP3CA/TP53/KCNQ1OT1 5 GO:0071378 cellular response to growth hormone stimulus 5/852 24/18722 0.0039817646414607 0.0328758953867184 GDF15/PXN/CSH1/PTK2/PIK3R1 5 GO:1905897 regulation of response to endoplasmic reticulum stress 10/852 82/18722 0.00398456113369724 0.0328758953867184 ABCA7/XBP1/WFS1/HERPUD1/SERINC3/PPP1R15B/TMBIM6/PIK3R1/TMEM259/ERP29 10 GO:0070372 regulation of ERK1 and ERK2 cascade 25/852 309/18722 0.00400894029463971 0.0330229075334233 FN1/TIMP3/FBLN1/ERBB2/ABCA7/CAMK2N1/TGFB1/PTK2B/APOE/EPHB2/CCR1/NOTCH2/CSF1R/ATF3/TIAM1/DUSP4/TPBG/LRP1/MIF/SEMA7A/MAPK3/NPTN/EZR/ERRFI1/ATP6AP1 25 GO:0031960 response to corticosteroid 16/852 167/18722 0.00402467387634398 0.0330983392477766 PAPPA/SPARC/ENG/ADM/HSD3B1/PAM/SMYD3/FBXO32/SDC1/ADAM9/GBA/ZFP36L1/FOSB/MDK/GLB1/ERRFI1 16 GO:0043410 positive regulation of MAPK cascade 35/852 480/18722 0.00423362580355766 0.0347599325763551 IGF2/FLT1/TIMP2/FGFR1/GDF15/ERBB2/ABCA7/TGFB1/TGFB2/PTK2B/APOE/CCR1/SEMA4C/NOTCH2/CSF1R/EFNA1/INSR/SASH1/TIAM1/ADAM9/CTNNB1/TPBG/CAV2/MAGED1/LRP1/MIF/SEMA7A/MAPK3/IQGAP1/BCAR3/NPTN/MYDGF/EMC10/ATP6AP1/ERP29 35 GO:0007517 muscle organ development 26/852 327/18722 0.00425940519268966 0.0349146357244414 IGF2/TPM1/ENG/NOG/FLNB/CITED2/SMAD3/TGFB1/TGFB2/ID3/XBP1/PKP2/ATF3/CTNNB1/RCAN1/DAG1/CAV2/LAMA5/EGR1/GPC1/CD164/PPP3CA/KLF5/DDX17/TGFBR3/SRI 26 GO:0031668 cellular response to extracellular stimulus 21/852 246/18722 0.00434581666695339 0.0355650329833763 AOC1/SFRP1/PTN/PRKAG2/LPL/NUAK1/MFSD2A/XBP1/GCN1/ATF3/BMPR2/DAP/WIPI1/GBA/NCOA1/MAPK3/KLF10/TP53/LAMP2/ATF4/SH3GLB1 21 GO:0018212 peptidyl-tyrosine modification 29/852 378/18722 0.00437963968256882 0.0357836469518975 IGF2/FLT1/IL6ST/ITGA5/FGFR1/SFRP1/SH3BP5/ERBB2/CSH1/TGFB1/GPRC5A/PTK2B/EPHB2/CSF1R/EFNA1/INSR/ARHGEF2/CBLB/JAK1/PTK2/ERBB3/MIF/MAPK3/IQGAP1/HIPK3/TP53/WEE1/ERRFI1/ADAM17 29 GO:0030216 keratinocyte differentiation 14/852 139/18722 0.00443183158819272 0.0361513912210275 FLNB/UGCG/FOSL2/PALLD/CLIC4/GRHL2/SGPP1/ADAM9/ZFP36L1/OPN3/SRSF6/KRT10/ERRFI1/GRHL1 14 GO:0055001 muscle cell development 17/852 184/18722 0.00447218829057414 0.0364058202850131 TPM1/ENG/ITGB1/ADM/KRT19/PDLIM5/KRT8/SMYD3/FHL2/SDC1/RCAN1/CAV2/ACTN4/PPP3CA/CSRP1/ACTN1/OBSL1 17 GO:0055010 ventricular cardiac muscle tissue morphogenesis 7/852 46/18722 0.00447748912307234 0.0364058202850131 TPM1/ENG/NOG/TGFB1/TGFB2/PKP2/TGFBR3 7 GO:1902105 regulation of leukocyte differentiation 23/852 279/18722 0.00449722622013354 0.0365073218805357 FSTL3/HLA-G/FBN1/SFRP1/GATA3/ERBB2/GATA2/TGFB1/INHA/SOX4/CCR1/XBP1/NOTCH2/MMP14/CTNNB1/UBASH3B/ZFP36L1/KLF10/NDFIP1/MDK/PIK3R1/CLPTM1/ATP6AP1 23 GO:0002931 response to ischemia 8/852 58/18722 0.00454030862001619 0.0366878331382241 CSF1R/EIF4EBP1/RCAN1/PINK1/EGR1/PIK3CB/P2RX4/TP53 8 GO:0045604 regulation of epidermal cell differentiation 8/852 58/18722 0.00454030862001619 0.0366878331382241 GRHL2/SGPP1/ZFP36L1/MYCL/MYCN/SRSF6/ERRFI1/GRHL1 8 GO:0051346 negative regulation of hydrolase activity 29/852 379/18722 0.00454362513858242 0.0366878331382241 SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/MGAT5/TIMP1/F11R/CST6/APOC1/ANGPTL4/TGFB2/PCSK1N/SERPINH1/CRIM1/TMED2/SH3BP4/PICALM/TMED10/BST2/LRP1/LGALS3/HERPUD1/FURIN/XIAP/TMBIM6/SPINT1/SERPINB6 29 GO:0070167 regulation of biomineral tissue development 11/852 97/18722 0.00456408767575221 0.0366878331382241 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2 11 GO:0070252 actin-mediated cell contraction 11/852 97/18722 0.00456408767575221 0.0366878331382241 TPM1/LIMCH1/KCNJ2/FLNA/PARVA/PKP2/DSG2/GJA5/JUP/GSN/SRI 11 GO:0032350 regulation of hormone metabolic process 6/852 35/18722 0.0045704890478177 0.0366878331382241 TCF7L2/ADM/GATA3/H6PD/EGR1/RDH10 6 GO:0050654 chondroitin sulfate proteoglycan metabolic process 6/852 35/18722 0.0045704890478177 0.0366878331382241 BGN/CHPF/UGDH/DSEL/CHPF2/DSE 6 GO:0001938 positive regulation of endothelial cell proliferation 12/852 111/18722 0.00462156452360688 0.0370387488014545 IGF2/FGFR1/ACVRL1/SEMA5A/GATA2/PGF/BMPR2/CAV2/MYDGF/MDK/ADAM17/EMC10 12 GO:0006112 energy reserve metabolic process 10/852 84/18722 0.00474216893075161 0.0379345755760852 IGF2/IL6ST/PRKAG2/POMC/PHKG1/GAA/INSR/GFPT1/PPP1CB/PYGL 10 GO:0033555 multicellular organismal response to stress 9/852 71/18722 0.00476479039712114 0.0379345755760852 SLC6A2/TSPO/APOE/EDNRB/CAPN2/PPP3CA/P2RX4/MDK/DPP4 9 GO:0050818 regulation of coagulation 9/852 71/18722 0.00476479039712114 0.0379345755760852 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/PROCR/APOE/EPHB2/UBASH3B 9 GO:0090330 regulation of platelet aggregation 5/852 25/18722 0.00479363998934834 0.0379345755760852 SERPINE2/IL6ST/CD9/F11R/UBASH3B 5 GO:0140448 signaling receptor ligand precursor processing 5/852 25/18722 0.00479363998934834 0.0379345755760852 PCSK1N/CTSL/PCSK6/CTSZ/FURIN 5 GO:1903055 positive regulation of extracellular matrix organization 5/852 25/18722 0.00479363998934834 0.0379345755760852 SMAD3/TGFB1/PHLDB2/COLGALT1/DAG1 5 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 5/852 25/18722 0.00479363998934834 0.0379345755760852 TGFB1/NCOR2/MYCN/PPP3CA/TP53 5 GO:1905048 regulation of metallopeptidase activity 5/852 25/18722 0.00479363998934834 0.0379345755760852 TIMP3/TIMP2/TIMP1/PICALM/LRP1 5 GO:0052548 regulation of endopeptidase activity 32/852 432/18722 0.00482705546968632 0.0381390426670821 SERPINE2/TIMP3/SERPINE1/TNFSF10/TIMP2/EGLN3/SERPING1/TFPI/TIMP1/CST6/SMAD3/PCSK1N/HIP1/SERPINH1/RPS27L/CRIM1/EFNA1/DAP/PICALM/DAPK1/TMED10/BST2/TBC1D10A/NLRP2/HERPUD1/FURIN/CTSH/XIAP/NCSTN/GSN/SPINT1/SERPINB6 32 GO:0030099 myeloid cell differentiation 29/852 381/18722 0.00488713077961131 0.0385531805858679 FSTL3/EPAS1/FBN1/SFRP1/CITED2/GATA3/GATA2/SH3PXD2A/TGFB1/PTK2B/INHA/CCR1/PTBP3/NOTCH2/CSF1R/ISG15/CTNNB1/GBA/MYH9/UBASH3B/ZFP36L1/KLF10/RBFOX2/OSTM1/NDFIP1/PIK3R1/ACTN1/TGFBR3/ATP6AP1 29 GO:0006470 protein dephosphorylation 23/852 281/18722 0.00490170400839468 0.0386076311021134 PTPRF/MGAT5/ITGA1/PTPRS/TGFB1/NUAK1/HSP90B1/GBA/UBASH3B/RCAN1/PINK1/PPP1CB/LGALS3/CTDSP1/PPP3CA/SSH2/PPP1R15B/PPP2R5E/SYMPK/PTPN3/CAMTA1/PTP4A1/CTDNEP1 23 GO:0043406 positive regulation of MAP kinase activity 12/852 112/18722 0.00496791976053918 0.0387593721072447 FLT1/FGFR1/ERBB2/TGFB1/PTK2B/INSR/SASH1/TIAM1/ADAM9/MAGED1/IQGAP1/ERP29 12 GO:0009299 mRNA transcription 4/852 16/18722 0.00499797983262504 0.0387593721072447 FLNA/HIPK3/TP53/ATF4 4 GO:0021535 cell migration in hindbrain 4/852 16/18722 0.00499797983262504 0.0387593721072447 ITGB1/FLNA/SEMA4C/RBFOX2 4 GO:0031268 pseudopodium organization 4/852 16/18722 0.00499797983262504 0.0387593721072447 CDC42EP5/SRGAP2C/SRGAP2/CDC42EP1 4 GO:0033631 cell-cell adhesion mediated by integrin 4/852 16/18722 0.00499797983262504 0.0387593721072447 ITGB1/PLPP3/ADAM9/DPP4 4 GO:0034375 high-density lipoprotein particle remodeling 4/852 16/18722 0.00499797983262504 0.0387593721072447 APOC1/APOE/SCARB1/LIPG 4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 4/852 16/18722 0.00499797983262504 0.0387593721072447 APOE/ADAM9/SH3D19/FURIN 4 GO:1901163 regulation of trophoblast cell migration 4/852 16/18722 0.00499797983262504 0.0387593721072447 TIMP1/ARHGDIB/SYDE1/CALR 4 GO:1901201 regulation of extracellular matrix assembly 4/852 16/18722 0.00499797983262504 0.0387593721072447 SMAD3/TGFB1/PHLDB2/DAG1 4 GO:2001224 positive regulation of neuron migration 4/852 16/18722 0.00499797983262504 0.0387593721072447 FLNA/SRGAP2C/ARHGEF2/MDK 4 GO:0030183 B cell differentiation 14/852 141/18722 0.0050319060205881 0.0389624353871076 ITGB1/SFRP1/PLCL2/PTK2B/INHA/XBP1/NOTCH2/MMP14/HDAC5/KLF6/ZFP36L1/TP53/PIK3R1/ADAM17 14 GO:0035306 positive regulation of dephosphorylation 8/852 59/18722 0.00504798156544408 0.0390198046931218 ITGA1/SMAD3/TGFB1/GBA/PINK1/PPP1R15B/SYMPK/CAMTA1 8 GO:0030833 regulation of actin filament polymerization 16/852 171/18722 0.00506257350777043 0.0390198046931218 COTL1/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/VASP/NCKAP1/CDC42EP1/EVL/CTTN/SSH2/GSN/MYO1C 16 GO:0046890 regulation of lipid biosynthetic process 16/852 171/18722 0.00506257350777043 0.0390198046931218 ADM/TSPO/APOC1/LPCAT1/APOE/MFSD2A/SCARB1/INSIG1/H6PD/FABP5/LDLR/EGR1/CAPN2/RDH10/CTDNEP1/ACSL3 16 GO:0051224 negative regulation of protein transport 13/852 127/18722 0.0052225738939984 0.0401352419000716 SFRP1/APOE/OS9/INSIG1/LMAN1/TXN/PKIG/NDFIP2/PPP3CA/NDFIP1/LYPLA1/ERP29/FRMD4A 13 GO:0005977 glycogen metabolic process 9/852 72/18722 0.00523121770046632 0.0401352419000716 IGF2/IL6ST/PRKAG2/POMC/PHKG1/GAA/INSR/PPP1CB/PYGL 9 GO:0030032 lamellipodium assembly 9/852 72/18722 0.00523121770046632 0.0401352419000716 ITGB1/SRGAP2/RHOD/NCKAP1/DNM2/ARHGEF7/VCL/PIK3R1/GOLPH3 9 GO:0006644 phospholipid metabolic process 29/852 383/18722 0.00525218408976818 0.0402347679205529 HEXB/APOC1/PLA2G7/LPL/LPCAT1/GDPD3/MFSD2A/SCARB1/SGMS2/CSF1R/PIGT/IPMK/PLPP3/SGPP1/LIPG/FABP5/LDLR/DGKZ/PIK3CB/SLC44A2/CAPN2/GPX4/SERINC3/INPPL1/PIK3R1/ACSL3/GPAA1/IMPA2/SERINC2 29 GO:0009225 nucleotide-sugar metabolic process 6/852 36/18722 0.00527756815243121 0.0403677819318941 UGDH/SLC35A3/MGAT1/GFPT1/PGM3/UXS1 6 GO:0042110 T cell activation 35/852 487/18722 0.00529659722648319 0.0404518571181941 IGF2/EBI3/IL6ST/HLA-G/GATA3/SDC4/ERBB2/CD276/SMAD3/EFNB1/SLC7A1/SOX4/CTSL/CD151/XBP1/ELF4/CBLB/CTNNB1/GBA/MYH9/ZFP36L1/EGR1/LGALS3/KDELR1/PPP3CA/TP53/NDFIP1/MDK/NCSTN/DDOST/HSPH1/GSN/ADAM17/CLPTM1/DPP4 35 GO:0110149 regulation of biomineralization 11/852 99/18722 0.0053305921343127 0.0406192853198071 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2 11 GO:0031623 receptor internalization 12/852 113/18722 0.00533466075827389 0.0406192853198071 ITGB1/ADM/CD9/CD63/ANKRD13A/INSR/DNM2/PICALM/LMBRD1/LRP1/EZR/FMR1 12 GO:1901136 carbohydrate derivative catabolic process 16/852 172/18722 0.00535346722218093 0.040700907143862 HEXB/TGFB1/CTSL/GM2A/MGAT1/GBA/NAGLU/FUCA2/MAN1B1/GPC1/HEXA/GNS/STT3B/EDEM3/GLB1/NEU1 16 GO:0032869 cellular response to insulin stimulus 18/852 203/18722 0.00538596293166477 0.0408862012595306 IGF2/LPL/BAIAP2L1/XBP1/INSIG1/RAB8B/INSR/EIF4EBP2/AP3S1/HDAC5/CAV2/ZFP36L1/YWHAG/BCAR3/USO1/PIK3R1/ERRFI1/MYO1C 18 GO:0030308 negative regulation of cell growth 17/852 188/18722 0.00554313519600711 0.0420159630143129 SERPINE2/SFRP1/ACVRL1/SEMA5A/PTPRS/SMAD3/ADAM15/TGFB1/TGFB2/SEMA4C/BMPR2/SH3BP4/RTN4/BST2/JADE1/SEMA7A/TP53 17 GO:0006639 acylglycerol metabolic process 13/852 128/18722 0.0055780389537302 0.0421311629434435 APOC1/LPL/APOE/MFSD2A/SCARB1/INSIG1/MGLL/LIPG/LDLR/ACSL4/DGKZ/SEL1L/CTDNEP1 13 GO:0031638 zymogen activation 8/852 60/18722 0.00559794594236859 0.0421311629434435 SERPINE2/SERPINE1/CTSL/MMP14/CTSZ/TBC1D10A/FURIN/CTSH 8 GO:0006493 protein O-linked glycosylation 10/852 86/18722 0.00560855934275922 0.0421311629434435 PLOD3/B3GNT7/GALNT7/GALNT6/GALNT3/GALNT2/TET3/PGM3/B4GALT5/GALNT1 10 GO:0014031 mesenchymal cell development 10/852 86/18722 0.00560855934275922 0.0421311629434435 FN1/CITED2/SEMA5A/EFNB1/EDNRB/SEMA4C/LAMA5/SEMA7A/MAPK3/RDH10 10 GO:0034103 regulation of tissue remodeling 10/852 86/18722 0.00560855934275922 0.0421311629434435 SFRP1/TGFB1/CSF1R/LTBP3/TNFAIP3/UBASH3B/PPP3CA/TP53/MDK/ATP6AP1 10 GO:0048864 stem cell development 10/852 86/18722 0.00560855934275922 0.0421311629434435 FN1/CITED2/SEMA5A/EFNB1/EDNRB/SEMA4C/LAMA5/SEMA7A/MAPK3/RDH10 10 GO:0045861 negative regulation of proteolysis 27/852 351/18722 0.00563581200532529 0.0422727896017917 SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/IL1R2/CAMK2N1/PCSK1N/TMEM59/SERPINH1/CRIM1/EFNA1/PICALM/TMED10/BST2/CTSZ/LRP1/HERPUD1/FURIN/TP53/XIAP/PTPN3/SPINT1/SERPINB6 27 GO:1902003 regulation of amyloid-beta formation 7/852 48/18722 0.00569525932453784 0.0423646310118198 ABCA7/APOE/EFNA1/PICALM/RTN4/TMED10/RTN2 7 GO:1903053 regulation of extracellular matrix organization 7/852 48/18722 0.00569525932453784 0.0423646310118198 SMAD3/TGFB1/PHLDB2/COLGALT1/DAG1/LRP1/DPP4 7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 7/852 48/18722 0.00569525932453784 0.0423646310118198 TIMP3/TNFSF10/SFRP1/ATF3/PEA15/PDIA3/ITM2C 7 GO:0001573 ganglioside metabolic process 5/852 26/18722 0.00571637364408503 0.0423646310118198 HEXB/GM2A/HEXA/B4GALT5/NEU1 5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 5/852 26/18722 0.00571637364408503 0.0423646310118198 SEC61A1/SSR3/TRAM2/TRAM1/SEC63 5 GO:0010875 positive regulation of cholesterol efflux 5/852 26/18722 0.00571637364408503 0.0423646310118198 ABCA7/APOE/ABCA1/LRP1/RXRA 5 GO:0046697 decidualization 5/852 26/18722 0.00571637364408503 0.0423646310118198 CITED2/PTN/CTSB/MAPK3/BSG 5 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 5/852 26/18722 0.00571637364408503 0.0423646310118198 TGFB1/NCOR2/MYCN/PPP3CA/TP53 5 GO:0006073 cellular glucan metabolic process 9/852 73/18722 0.00573223002564063 0.0423646310118198 IGF2/IL6ST/PRKAG2/POMC/PHKG1/GAA/INSR/PPP1CB/PYGL 9 GO:0044042 glucan metabolic process 9/852 73/18722 0.00573223002564063 0.0423646310118198 IGF2/IL6ST/PRKAG2/POMC/PHKG1/GAA/INSR/PPP1CB/PYGL 9 GO:0006664 glycolipid metabolic process 11/852 100/18722 0.00575015186469332 0.0424347717522016 HEXB/UGCG/GM2A/PIGT/GBA/ST3GAL6/HEXA/B4GALT5/GLB1/NEU1/GPAA1 11 GO:0048562 embryonic organ morphogenesis 23/852 285/18722 0.00580164937340901 0.042752124884872 MFAP5/ENG/FBN1/NOG/CITED2/GATA3/MFAP2/GATA2/SMAD3/EPHB2/NOTCH2/MMP14/TMED2/INSIG1/EFNA1/GRHL2/CTNNB1/NAGLU/MAPK3/MYO6/FBN2/MYCN/RDH10 23 GO:0006638 neutral lipid metabolic process 13/852 129/18722 0.00595257769692368 0.0438001806266329 APOC1/LPL/APOE/MFSD2A/SCARB1/INSIG1/MGLL/LIPG/LDLR/ACSL4/DGKZ/SEL1L/CTDNEP1 13 GO:0008406 gonad development 19/852 221/18722 0.00600718592901251 0.0441374697528759 FSTL3/TNFSF10/NRIP1/SFRP1/CITED2/GATA3/ADAMTS1/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/NCOA1/PLEKHA1/RHOBTB3/RDH10/TFAP2C 19 GO:0032570 response to progesterone 6/852 37/18722 0.00606151625942695 0.0444070033969372 PTN/TSPO/TGFB1/TGFB2/NCOA1/FOSB 6 GO:0045616 regulation of keratinocyte differentiation 6/852 37/18722 0.00606151625942695 0.0444070033969372 GRHL2/SGPP1/ZFP36L1/SRSF6/ERRFI1/GRHL1 6 GO:0030041 actin filament polymerization 17/852 190/18722 0.00615208157249348 0.0449641617843034 COTL1/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/VASP/NCKAP1/CDC42EP1/EVL/CTTN/SSH2/TTC17/GSN/MYO1C 17 GO:0051222 positive regulation of protein transport 24/852 303/18722 0.00615543561879298 0.0449641617843034 TCF7L2/ERBB2/SMAD3/CAMK2N1/TGFB1/TGFB2/SOX4/FLNA/RHOU/ADAM9/TMED10/PINK1/ACSL4/LRP1/SAR1A/EZR/JUP/PIK3R1/GOLPH3/MYO1C/ACSL3/SH3GLB1/SRI/FRMD4A 24 GO:0030865 cortical cytoskeleton organization 8/852 61/18722 0.00619238961671283 0.0450589944117349 CALR/RHOD/NCKAP1/RHOBTB3/FMNL2/EZR/RHOC/RND3 8 GO:0040014 regulation of multicellular organism growth 8/852 61/18722 0.00619238961671283 0.0450589944117349 IGF2/PLAC8/GDF15/MFSD2A/TNKS2/PPIB/ATRN/EZR 8 GO:1903509 liposaccharide metabolic process 11/852 101/18722 0.00619527600495143 0.0450589944117349 HEXB/UGCG/GM2A/PIGT/GBA/ST3GAL6/HEXA/B4GALT5/GLB1/NEU1/GPAA1 11 GO:0007040 lysosome organization 9/852 74/18722 0.00626947051181224 0.0451928468770231 HEXB/GRN/GAA/ABCA1/SCARB2/GBA/CLN5/NAGLU/ARL8B 9 GO:0080171 lytic vacuole organization 9/852 74/18722 0.00626947051181224 0.0451928468770231 HEXB/GRN/GAA/ABCA1/SCARB2/GBA/CLN5/NAGLU/ARL8B 9 GO:0032386 regulation of intracellular transport 26/852 337/18722 0.00627599913579155 0.0451928468770231 TCF7L2/IFI27/ERBB2/SMAD3/TGFB1/FLNA/RHOU/OS9/INSIG1/LMAN1/LAMP1/NUCB1/PINK1/TXN/PKIG/ARHGAP1/MAPK3/RNF139/SAR1A/EZR/JUP/YIPF5/PIK3R1/MYO1C/SH3GLB1/REEP5 26 GO:0062197 cellular response to chemical stress 26/852 337/18722 0.00627599913579155 0.0451928468770231 TPM1/EPAS1/IL18BP/MMP2/P4HB/TSPO/PXN/PYCR1/ENDOG/HSPB1/SOD3/TNFAIP3/GPX8/ARHGEF2/CTNNB1/DAPK1/PINK1/PLEKHA1/TXN/ZFP36L1/MAPK3/EFHD1/TP53/ERRFI1/ATF4/SERPINB6 26 GO:0010934 macrophage cytokine production 4/852 17/18722 0.00630347278117827 0.0451928468770231 HLA-G/TGFB1/TGFB2/SEMA7A 4 GO:0010935 regulation of macrophage cytokine production 4/852 17/18722 0.00630347278117827 0.0451928468770231 HLA-G/TGFB1/TGFB2/SEMA7A 4 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 4/852 17/18722 0.00630347278117827 0.0451928468770231 HLA-G/TAP1/TAPBP/ERAP1 4 GO:0042339 keratan sulfate metabolic process 4/852 17/18722 0.00630347278117827 0.0451928468770231 B3GNT7/ST3GAL6/GNS/GLB1 4 GO:0061298 retina vasculature development in camera-type eye 4/852 17/18722 0.00630347278117827 0.0451928468770231 COL4A1/ACVRL1/CLIC4/BMPR2 4 GO:0061450 trophoblast cell migration 4/852 17/18722 0.00630347278117827 0.0451928468770231 TIMP1/ARHGDIB/SYDE1/CALR 4 GO:0030195 negative regulation of blood coagulation 7/852 49/18722 0.00638960710934033 0.0455508393502973 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/APOE/UBASH3B 7 GO:0045778 positive regulation of ossification 7/852 49/18722 0.00638960710934033 0.0455508393502973 PTN/SMAD3/TGFB1/TGFB2/ISG15/BMPR2/FBN2 7 GO:0060964 regulation of gene silencing by miRNA 7/852 49/18722 0.00638960710934033 0.0455508393502973 TGFB1/NCOR2/MYCN/PPP3CA/TP53/FMR1/KCNQ1OT1 7 GO:1990928 response to amino acid starvation 7/852 49/18722 0.00638960710934033 0.0455508393502973 GCN1/EIF4EBP1/ATF3/DAP/MAPK3/ATF4/SH3GLB1 7 GO:1902106 negative regulation of leukocyte differentiation 11/852 102/18722 0.00666700208320806 0.0474611336418475 FSTL3/HLA-G/FBN1/SFRP1/ERBB2/GATA2/INHA/CTNNB1/UBASH3B/MDK/PIK3R1 11 GO:0003171 atrioventricular valve development 5/852 27/18722 0.0067574730967834 0.0479793095779911 TGFB2/SOX4/EFNA1/BMPR2/GJA5 5 GO:1904950 negative regulation of establishment of protein localization 13/852 131/18722 0.00676171125398647 0.0479793095779911 SFRP1/APOE/OS9/INSIG1/LMAN1/TXN/PKIG/NDFIP2/PPP3CA/NDFIP1/LYPLA1/ERP29/FRMD4A 13 GO:0036294 cellular response to decreased oxygen levels 15/852 161/18722 0.00677792352671403 0.0479793095779911 EGLN3/EPAS1/SFRP1/CITED2/PTN/P4HB/ENDOG/EIF4EBP1/PINK1/ZFP36L1/EGR1/NDRG1/TP53/ERO1A/TMBIM6 15 GO:0051650 establishment of vesicle localization 15/852 161/18722 0.00677792352671403 0.0479793095779911 TMED2/AP3S1/WIPI1/SNAP23/CTNNB1/DNM2/PICALM/TMED10/PINK1/MYO6/ACTN4/SAR1A/TMED9/ARFGAP3/MYO1C 15 GO:0048813 dendrite morphogenesis 14/852 146/18722 0.00682187775267319 0.0481696174445794 ITGB1/PTN/PDLIM5/EPHB2/EFNA1/ADAM10/TIAM1/PICALM/TPBG/RBFOX2/PPP3CA/ID1/CUX1/OBSL1 14 GO:0048002 antigen processing and presentation of peptide antigen 8/852 62/18722 0.00683352013817399 0.0481696174445794 HLA-G/CTSL/TAP1/TAPBP/CALR/DNM2/CTSF/ERAP1 8 GO:1903078 positive regulation of protein localization to plasma membrane 8/852 62/18722 0.00683352013817399 0.0481696174445794 ITGB1/ARHGEF16/EPHB2/LRP1/LGALS3/EZR/PIK3R1/ACSL3 8 GO:0032373 positive regulation of sterol transport 6/852 38/18722 0.00692691541046016 0.0486236614516681 ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA 6 GO:0032376 positive regulation of cholesterol transport 6/852 38/18722 0.00692691541046016 0.0486236614516681 ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA 6 GO:0097242 amyloid-beta clearance 6/852 38/18722 0.00692691541046016 0.0486236614516681 ABCA7/APOE/INSR/PICALM/LDLR/LRP1 6 GO:0051648 vesicle localization 16/852 177/18722 0.00701835561686419 0.0491284893180493 TMED2/AP3S1/WIPI1/SNAP23/CTNNB1/DNM2/PICALM/TMED10/PINK1/MYO6/ACTN4/SAR1A/TMED9/USO1/ARFGAP3/MYO1C 16 GO:0071453 cellular response to oxygen levels 16/852 177/18722 0.00701835561686419 0.0491284893180493 EGLN3/EPAS1/SFRP1/CITED2/PTN/P4HB/ENDOG/EIF4EBP1/PINK1/ZFP36L1/EGR1/NDRG1/TP53/ERO1A/TMBIM6/ATP6AP1 16 GO:0050808 synapse organization 31/852 426/18722 0.00703392946363968 0.0491691208201368 SPARC/PTPRF/COL4A1/IL1RAP/PTN/PDLIM5/PLXNB2/ERBB2/PTPRS/GPC4/APOE/PPFIBP2/EPHB2/FLNA/LAMB2/ACTB/EFNA1/INSR/ADAM10/TIAM1/CTNNB1/CTBP2/SDF4/DAG1/TPBG/NDRG1/ARF4/CTTN/NPTN/ACTN1/OBSL1 31 GO:1900047 negative regulation of hemostasis 7/852 50/18722 0.00714503533373277 0.0498765087859598 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/APOE/UBASH3B 7 GO:0001935 endothelial cell proliferation 17/852 193/18722 0.00716622410393116 0.0499551328463789 IGF2/FLT1/SPARC/FGFR1/ACVRL1/SEMA5A/GATA2/APOE/SCARB1/PGF/MMP14/BMPR2/CAV2/MYDGF/MDK/ADAM17/EMC10 17 GO:0045667 regulation of osteoblast differentiation 13/852 132/18722 0.0071977481140717 0.0501054858341948 IL6ST/NOG/SFRP1/SMAD3/WWTR1/ID3/CRIM1/BMPR2/CTNNB1/PTK2/FBN2/ATF4/ATP6AP1 13 GO:0043254 regulation of protein-containing complex assembly 31/852 427/18722 0.00726634696674129 0.0505131550878576 COTL1/TMSB10/CAPG/TGFB1/FBLIM1/PTK2B/ESAM/APOE/BAIAP2L1/CDC42EP5/MYADM/STXBP5/ISG15/EIF4EBP1/VASP/ABCA1/NCKAP1/GBA/PINK1/CDC42EP1/EVL/LGALS3/CTTN/SAR1A/SSH2/TP53/ARHGEF7/GSN/MYO1C/RHOC/SH3GLB1 31 GO:1901654 response to ketone 17/852 194/18722 0.00753276618271964 0.0522929823415558 SFRP1/PTN/HSD3B1/TSPO/ADAM15/TGFB1/TGFB2/SMYD3/FBXO32/CALR/GBA/NCOA1/FOSB/GLB1/GOLPH3/ERRFI1/TGFBR3 17 GO:0045637 regulation of myeloid cell differentiation 18/852 210/18722 0.00758991522380155 0.0526171395611476 FSTL3/FBN1/SFRP1/GATA2/TGFB1/PTK2B/INHA/CCR1/NOTCH2/ISG15/CTNNB1/UBASH3B/ZFP36L1/KLF10/RBFOX2/NDFIP1/PIK3R1/ATP6AP1 18 GO:0045638 negative regulation of myeloid cell differentiation 10/852 90/18722 0.00770838155395725 0.05336490283503 FSTL3/FBN1/SFRP1/GATA2/PTK2B/INHA/CTNNB1/UBASH3B/ZFP36L1/PIK3R1 10 GO:0030206 chondroitin sulfate biosynthetic process 4/852 18/18722 0.00781684655022153 0.0537461594088319 CHPF/UGDH/CHPF2/DSE 4 GO:0036499 PERK-mediated unfolded protein response 4/852 18/18722 0.00781684655022153 0.0537461594088319 ABCA7/TMED2/PPP1R15B/ATF4 4 GO:0051895 negative regulation of focal adhesion assembly 4/852 18/18722 0.00781684655022153 0.0537461594088319 ACVRL1/PHLDB2/MMP14/LRP1 4 GO:0150118 negative regulation of cell-substrate junction organization 4/852 18/18722 0.00781684655022153 0.0537461594088319 ACVRL1/PHLDB2/MMP14/LRP1 4 GO:1902683 regulation of receptor localization to synapse 4/852 18/18722 0.00781684655022153 0.0537461594088319 GPC4/ADAM10/DAG1/NPTN 4 GO:1903115 regulation of actin filament-based movement 6/852 39/18722 0.00787831382318884 0.0540242206804334 KCNJ2/PKP2/DSG2/GJA5/JUP/SRI 6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 5/852 28/18722 0.00792426184954814 0.0540242206804334 HLA-G/TAP1/TAPBP/CALR/ERAP1 5 GO:0006516 glycoprotein catabolic process 5/852 28/18722 0.00792426184954814 0.0540242206804334 CTSL/MAN1B1/GPC1/STT3B/EDEM3 5 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 5/852 28/18722 0.00792426184954814 0.0540242206804334 ITGA1/GPRC5A/CBLB/PTPN3/ERRFI1 5 GO:0045137 development of primary sexual characteristics 19/852 227/18722 0.00793388633770373 0.0540242206804334 FSTL3/TNFSF10/NRIP1/SFRP1/CITED2/GATA3/ADAMTS1/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/NCOA1/PLEKHA1/RHOBTB3/RDH10/TFAP2C 19 GO:0030100 regulation of endocytosis 18/852 211/18722 0.00795701762060016 0.0540242206804334 SERPINE1/APOC1/GATA2/ABCA7/APOE/HIP1/CD151/CD63/ANKRD13A/INSR/DNM2/PICALM/SH3GL1/LRP1/PIK3CB/LGALS3/PPP3CA/FMR1 18 GO:0032964 collagen biosynthetic process 7/852 51/18722 0.00796462780546028 0.0540242206804334 ENG/RCN3/TGFB1/SERPINH1/P3H4/TRAM2/ERRFI1 7 GO:0046850 regulation of bone remodeling 7/852 51/18722 0.00796462780546028 0.0540242206804334 SFRP1/CSF1R/LTBP3/TNFAIP3/UBASH3B/MDK/ATP6AP1 7 GO:0048013 ephrin receptor signaling pathway 7/852 51/18722 0.00796462780546028 0.0540242206804334 MMP2/EFNB1/EPHB2/EFNA1/TIAM1/PTK2/ARHGEF7 7 GO:0065002 intracellular protein transmembrane transport 7/852 51/18722 0.00796462780546028 0.0540242206804334 SEC61A1/SEC61G/SEC62/TRAM2/TRAM1/SEC63/RTN2 7 GO:0001508 action potential 13/852 134/18722 0.00813643476236221 0.0550412313964637 CLDN19/KCNJ2/FLNA/PKP2/GBA/DSG2/GJA5/P2RX4/GNAQ/JUP/PTPN3/FMR1/SRI 13 GO:0042552 myelination 13/852 134/18722 0.00813643476236221 0.0550412313964637 HEXB/PTN/CD9/JAM2/ERBB2/MARVELD1/CTNNB1/DAG1/ATRN/NDRG1/GPC1/B4GALT5/NCSTN 13 GO:0001885 endothelial cell development 8/852 64/18722 0.0082647402697966 0.0558341446683037 F11R/PLOD3/PTPRS/MYADM/CLIC4/EZR/TJP2/VCL 8 GO:0071674 mononuclear cell migration 17/852 196/18722 0.00831110714239762 0.0560396601378416 FLT1/SERPINE1/GATA3/F11R/JAM2/PLA2G7/PTK2B/CCR1/CSF1R/CALR/ADAM10/GBA/PTK2/LGALS3/MAPK3/MDK/ADAM17 17 GO:0060191 regulation of lipase activity 10/852 91/18722 0.00831743018537009 0.0560396601378416 FLT1/FGFR1/APOC1/ANGPTL4/PCSK6/LRP1/ARF4/FURIN/GNAQ/RHOC 10 GO:0001649 osteoblast differentiation 19/852 229/18722 0.00867728819951041 0.058150398539717 IGF2/IL6ST/NOG/SFRP1/SMAD3/WWTR1/COL6A1/ID3/CRIM1/BMPR2/FHL2/CTNNB1/RRBP1/PTK2/SEMA7A/BCAP29/FBN2/ATF4/ATP6AP1 19 GO:0033157 regulation of intracellular protein transport 19/852 229/18722 0.00867728819951041 0.058150398539717 TCF7L2/IFI27/ERBB2/SMAD3/TGFB1/FLNA/RHOU/OS9/INSIG1/LMAN1/NUCB1/PINK1/TXN/PKIG/SAR1A/JUP/PIK3R1/MYO1C/SH3GLB1 19 GO:0032371 regulation of sterol transport 9/852 78/18722 0.00881416274728572 0.058150398539717 TSPO/APOC1/ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA/FURIN 9 GO:0032374 regulation of cholesterol transport 9/852 78/18722 0.00881416274728572 0.058150398539717 TSPO/APOC1/ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA/FURIN 9 GO:0034637 cellular carbohydrate biosynthetic process 9/852 78/18722 0.00881416274728572 0.058150398539717 IGF2/B3GNT7/PHKG1/B4GALT1/INSR/PPP1CB/B4GALT5/EXT2/IMPA2 9 GO:1903707 negative regulation of hemopoiesis 11/852 106/18722 0.00884110611529222 0.058150398539717 FSTL3/HLA-G/FBN1/SFRP1/ERBB2/GATA2/INHA/CTNNB1/UBASH3B/MDK/PIK3R1 11 GO:1905477 positive regulation of protein localization to membrane 11/852 106/18722 0.00884110611529222 0.058150398539717 ITGB1/PTN/ERBB2/ARHGEF16/EPHB2/LRP1/LGALS3/EZR/PIK3R1/MYO1C/ACSL3 11 GO:0060147 regulation of posttranscriptional gene silencing 7/852 52/18722 0.00885146101138478 0.058150398539717 TGFB1/NCOR2/MYCN/PPP3CA/TP53/FMR1/KCNQ1OT1 7 GO:0003183 mitral valve morphogenesis 3/852 10/18722 0.00886178336577845 0.058150398539717 SOX4/EFNA1/BMPR2 3 GO:0006012 galactose metabolic process 3/852 10/18722 0.00886178336577845 0.058150398539717 B4GALT1/GLB1/GALE 3 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 3/852 10/18722 0.00886178336577845 0.058150398539717 TMED2/PPP1R15B/DNAJC3 3 GO:0018242 protein O-linked glycosylation via serine 3/852 10/18722 0.00886178336577845 0.058150398539717 GALNT3/GALNT2/GALNT1 3 GO:0021932 hindbrain radial glia guided cell migration 3/852 10/18722 0.00886178336577845 0.058150398539717 ITGB1/FLNA/RBFOX2 3 GO:0035376 sterol import 3/852 10/18722 0.00886178336577845 0.058150398539717 SCARB1/LDLR/LRP1 3 GO:0036363 transforming growth factor beta activation 3/852 10/18722 0.00886178336577845 0.058150398539717 LTBP1/LTBP3/FURIN 3 GO:0048280 vesicle fusion with Golgi apparatus 3/852 10/18722 0.00886178336577845 0.058150398539717 USO1/SEC22B/YIPF5 3 GO:0070508 cholesterol import 3/852 10/18722 0.00886178336577845 0.058150398539717 SCARB1/LDLR/LRP1 3 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3/852 10/18722 0.00886178336577845 0.058150398539717 EFNA1/PICALM/TMED10 3 GO:1904350 regulation of protein catabolic process in the vacuole 3/852 10/18722 0.00886178336577845 0.058150398539717 GBA/LDLR/LRP1 3 GO:2000674 regulation of type B pancreatic cell apoptotic process 3/852 10/18722 0.00886178336577845 0.058150398539717 TCF7L2/WFS1/SRSF6 3 GO:0010543 regulation of platelet activation 6/852 40/18722 0.0089202072809498 0.0582300950000264 SERPINE2/IL6ST/CD9/F11R/APOE/UBASH3B 6 GO:0030501 positive regulation of bone mineralization 6/852 40/18722 0.0089202072809498 0.0582300950000264 PTN/SMAD3/TGFB1/ISG15/BMPR2/FBN2 6 GO:0043001 Golgi to plasma membrane protein transport 6/852 40/18722 0.0089202072809498 0.0582300950000264 SEC16A/LYPLA1/GOLPH3/KRT18/ACSL3/MACF1 6 GO:0060412 ventricular septum morphogenesis 6/852 40/18722 0.0089202072809498 0.0582300950000264 NOG/CITED2/TGFB2/SOX4/BMPR2/TGFBR3 6 GO:0051402 neuron apoptotic process 20/852 246/18722 0.00893997519250356 0.0582835429324747 EGLN3/GATA3/ITGA1/TGFB2/PTK2B/APOE/GRN/PIGT/WFS1/CTNNB1/GBA/PINK1/CTSZ/ERBB3/LRP1/TP53/XIAP/MDK/NCSTN/ATF4 20 GO:0003170 heart valve development 8/852 65/18722 0.00905929803958156 0.0587570193726985 GATA3/TGFB1/TGFB2/SOX4/NOTCH2/EFNA1/BMPR2/GJA5 8 GO:0046503 glycerolipid catabolic process 8/852 65/18722 0.00905929803958156 0.0587570193726985 APOC1/PLA2G7/LPL/GDPD3/SCARB1/MGLL/LIPG/LDLR 8 GO:0072577 endothelial cell apoptotic process 8/852 65/18722 0.00905929803958156 0.0587570193726985 SERPINE1/HLA-G/GATA3/SEMA5A/GATA2/ANGPTL4/TNFAIP3/BMPR2 8 GO:1905330 regulation of morphogenesis of an epithelium 8/852 65/18722 0.00905929803958156 0.0587570193726985 NOG/SFRP1/GATA3/NTN4/CTNNB1/MAGED1/BTBD7/MDK 8 GO:0048754 branching morphogenesis of an epithelial tube 14/852 151/18722 0.00908662050772234 0.058782726240831 COL4A1/ENG/NOG/MMP14/CLIC4/CTNNB1/DAG1/CTSZ/LAMA5/MAGED1/MYCN/RDH10/CTSH/MDK 14 GO:2001236 regulation of extrinsic apoptotic signaling pathway 14/852 151/18722 0.00908662050772234 0.058782726240831 TIMP3/SERPINE1/TNFSF10/FGFR1/SFRP1/TCF7L2/TNFAIP3/ARHGEF2/ATF3/PEA15/LGALS3/CTTN/PDIA3/ITM2C 14 GO:0007272 ensheathment of neurons 13/852 136/18722 0.00916892963784438 0.0590630799186732 HEXB/PTN/CD9/JAM2/ERBB2/MARVELD1/CTNNB1/DAG1/ATRN/NDRG1/GPC1/B4GALT5/NCSTN 13 GO:0008366 axon ensheathment 13/852 136/18722 0.00916892963784438 0.0590630799186732 HEXB/PTN/CD9/JAM2/ERBB2/MARVELD1/CTNNB1/DAG1/ATRN/NDRG1/GPC1/B4GALT5/NCSTN 13 GO:0072073 kidney epithelium development 13/852 136/18722 0.00916892963784438 0.0590630799186732 NOG/SFRP1/GATA3/SDC4/SMAD3/WWTR1/NOTCH2/LAMB2/SDC1/CTNNB1/LAMA5/MAGED1/IQGAP1 13 GO:0030970 retrograde protein transport, ER to cytosol 5/852 29/18722 0.00922383882695751 0.0590630799186732 OS9/HSP90B1/HM13/HERPUD1/SEL1L 5 GO:0048265 response to pain 5/852 29/18722 0.00922383882695751 0.0590630799186732 SLC6A2/TSPO/EDNRB/CAPN2/P2RX4 5 GO:0060441 epithelial tube branching involved in lung morphogenesis 5/852 29/18722 0.00922383882695751 0.0590630799186732 CTNNB1/DAG1/CTSZ/RDH10/CTSH 5 GO:0060969 negative regulation of gene silencing 5/852 29/18722 0.00922383882695751 0.0590630799186732 TGFB1/NCOR2/PPP3CA/TP53/KCNQ1OT1 5 GO:1903513 endoplasmic reticulum to cytosol transport 5/852 29/18722 0.00922383882695751 0.0590630799186732 OS9/HSP90B1/HM13/HERPUD1/SEL1L 5 GO:0051051 negative regulation of transport 33/852 470/18722 0.00926811679946239 0.0592711967620002 SERPINE2/RRAD/SFRP1/APOC1/ABCA7/PTK2B/APOE/INHA/EPHB2/SESTD1/ANKRD13A/OS9/CNN2/INSIG1/PEA15/LMAN1/PICALM/FABP5/BST2/TXN/PKIG/ERBB3/ARHGAP1/LGALS3/NDFIP2/PPP3CA/NDFIP1/TMBIM6/LYPLA1/FMR1/SRI/ERP29/FRMD4A 33 GO:0043087 regulation of GTPase activity 26/852 348/18722 0.00934950576691821 0.0597158153869281 ITGB1/SFRP1/F11R/ASAP3/PLXNB2/ERBB2/IQSEC1/SYDE1/PTK2B/MAPRE2/ARHGEF16/RALBP1/TMED2/SRGAP2/SH3BP4/TIAM1/CBLB/PICALM/CAV2/PTK2/TBC1D10A/IQGAP1/BCAR3/ARHGAP29/ARHGEF7/SGSM3 26 GO:0019216 regulation of lipid metabolic process 25/852 331/18722 0.00938667139204547 0.0597258117777053 FLT1/ADM/TSPO/PRKAG2/PSAP/APOC1/ABCA7/TGFB1/LPCAT1/PTK2B/APOE/MFSD2A/SCARB1/INSIG1/NPC2/H6PD/FABP5/LDLR/EGR1/DGKZ/PTK2/CAPN2/RDH10/CTDNEP1/ACSL3 25 GO:0071214 cellular response to abiotic stimulus 25/852 331/18722 0.00938667139204547 0.0597258117777053 ENG/SFRP1/PTN/GATA3/TIMP1/MMP2/F11R/TSPO/KCNJ2/CNN2/ARHGEF2/DNM2/DAG1/ZFP36L1/EGR1/OPN3/MAPK3/EFHD1/TP53/DDB1/PIK3R1/ERRFI1/FMR1/ATF4/SERPINB6 25 GO:0104004 cellular response to environmental stimulus 25/852 331/18722 0.00938667139204547 0.0597258117777053 ENG/SFRP1/PTN/GATA3/TIMP1/MMP2/F11R/TSPO/KCNJ2/CNN2/ARHGEF2/DNM2/DAG1/ZFP36L1/EGR1/OPN3/MAPK3/EFHD1/TP53/DDB1/PIK3R1/ERRFI1/FMR1/ATF4/SERPINB6 25 GO:0002483 antigen processing and presentation of endogenous peptide antigen 4/852 19/18722 0.0095505592546721 0.0601301028930999 HLA-G/TAP1/TAPBP/ERAP1 4 GO:0007039 protein catabolic process in the vacuole 4/852 19/18722 0.0095505592546721 0.0601301028930999 GBA/LDLR/LRP1/LAMP2 4 GO:0009226 nucleotide-sugar biosynthetic process 4/852 19/18722 0.0095505592546721 0.0601301028930999 UGDH/GFPT1/PGM3/UXS1 4 GO:0010544 negative regulation of platelet activation 4/852 19/18722 0.0095505592546721 0.0601301028930999 SERPINE2/CD9/APOE/UBASH3B 4 GO:0010759 positive regulation of macrophage chemotaxis 4/852 19/18722 0.0095505592546721 0.0601301028930999 CSF1R/PTK2/MAPK3/MDK 4 GO:0045947 negative regulation of translational initiation 4/852 19/18722 0.0095505592546721 0.0601301028930999 EIF4EBP1/EIF4EBP2/FMR1/ATF4 4 GO:0046794 transport of virus 4/852 19/18722 0.0095505592546721 0.0601301028930999 CTSL/BST2/CAV2/FMR1 4 GO:0060216 definitive hemopoiesis 4/852 19/18722 0.0095505592546721 0.0601301028930999 MFAP5/GATA2/RBFOX2/TGFBR3 4 GO:1901184 regulation of ERBB signaling pathway 9/852 79/18722 0.00955773540919529 0.0601301028930999 ITGA1/GPRC5A/HIP1/CBLB/RTN4/BCAR3/PTPN3/ERRFI1/ADAM17 9 GO:0042098 T cell proliferation 17/852 199/18722 0.00959820842798709 0.0601923346662036 IGF2/EBI3/IL6ST/HLA-G/SDC4/ERBB2/CD276/EFNB1/SLC7A1/CD151/ELF4/CBLB/CTNNB1/LGALS3/TP53/NDFIP1/NCSTN 17 GO:0008643 carbohydrate transport 14/852 152/18722 0.00960350580905255 0.0601923346662036 PRKAG2/SLC35A3/SLC23A2/MFSD2A/ASPSCR1/INSR/PEA15/FABP5/SLC17A5/OPN3/EZR/MFSD12/PIK3R1/RTN2 14 GO:0016125 sterol metabolic process 14/852 152/18722 0.00960350580905255 0.0601923346662036 PRKAG2/APOE/SCARB1/LIMA1/INSIG1/CYP11A1/ABCA1/NPC2/GBA/LDLR/RXRA/HDLBP/CYB5R3/CYB5R1 14 GO:0097306 cellular response to alcohol 10/852 93/18722 0.0096457766757782 0.0603820821009847 SFRP1/ADAM15/SLC23A2/ABCA1/CTNNB1/ADCY7/DAG1/ITPR2/JUP/GOLPH3 10 GO:0010977 negative regulation of neuron projection development 13/852 137/18722 0.00972225316256473 0.0606345726978789 SEMA5A/PTPRS/APOE/EPHB2/FLNA/SEMA4C/EFNA1/CARM1/RTN4/CTSZ/LRP1/SEMA7A/ITM2C 13 GO:0050714 positive regulation of protein secretion 13/852 137/18722 0.00972225316256473 0.0606345726978789 TCF7L2/CAMK2N1/TGFB1/TGFB2/SOX4/ADAM9/TMED10/ACSL4/LRP1/EZR/GOLPH3/SRI/FRMD4A 13 GO:0090090 negative regulation of canonical Wnt signaling pathway 13/852 137/18722 0.00972225316256473 0.0606345726978789 NOTUM/NOG/SFRP1/TCF7L2/WWTR1/APOE/TLE3/TPBG/EGR1/JADE1/CSNK1A1/MDK/AMFR 13 GO:0007566 embryo implantation 7/852 53/18722 0.00980859486780573 0.0610214481424321 FBLN1/TIMP1/MMP2/ARHGDIB/SYDE1/CALR/BSG 7 GO:0060966 regulation of gene silencing by RNA 7/852 53/18722 0.00980859486780573 0.0610214481424321 TGFB1/NCOR2/MYCN/PPP3CA/TP53/FMR1/KCNQ1OT1 7 GO:0014706 striated muscle tissue development 28/852 384/18722 0.00982065825459368 0.0610214481424321 IGF2/TPM1/ENG/NOG/ITGB1/FLNB/CITED2/PDLIM5/SMAD3/TGFB1/TGFB2/PKP2/NOTCH2/CALR/ATF3/FHL2/CTNNB1/DSG2/GJA5/RCAN1/CAV2/EGR1/GPC1/PPP3CA/KLF5/DDX17/TGFBR3/OBSL1 28 GO:0099173 postsynapse organization 15/852 168/18722 0.00987877835342204 0.0612707073951246 IL1RAP/PTN/PDLIM5/PTPRS/APOE/EPHB2/ACTB/EFNA1/INSR/ADAM10/TIAM1/NDRG1/ARF4/CTTN/ACTN1 15 GO:0030193 regulation of blood coagulation 8/852 66/18722 0.00990946867069967 0.0612707073951246 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/APOE/EPHB2/UBASH3B 8 GO:0042446 hormone biosynthetic process 8/852 66/18722 0.00990946867069967 0.0612707073951246 DIO2/ADM/HSD3B1/TSPO/SCARB1/CYP11A1/H6PD/EGR1 8 GO:0045600 positive regulation of fat cell differentiation 8/852 66/18722 0.00990946867069967 0.0612707073951246 SFRP1/LPL/XBP1/CARM1/ZFP36L1/AAMDC/KLF5/RREB1 8 GO:1903706 regulation of hemopoiesis 27/852 367/18722 0.00993416956483594 0.0613480679997783 FSTL3/HLA-G/FBN1/SFRP1/PTN/GATA3/ERBB2/GATA2/TGFB1/PTK2B/INHA/SOX4/CCR1/XBP1/NOTCH2/MMP14/ISG15/CTNNB1/UBASH3B/ZFP36L1/KLF10/RBFOX2/NDFIP1/MDK/PIK3R1/CLPTM1/ATP6AP1 27 GO:0071470 cellular response to osmotic stress 6/852 41/18722 0.0100570211254525 0.0620306217210814 TSPO/ARHGEF2/ZFP36L1/EFHD1/ERRFI1/SERPINB6 6 GO:0060537 muscle tissue development 29/852 403/18722 0.0103272230024169 0.0636192330124408 IGF2/TPM1/ENG/NOG/ITGB1/FLNB/CITED2/PDLIM5/SMAD3/TGFB1/TGFB2/PKP2/NOTCH2/CALR/ATF3/FHL2/CTNNB1/DSG2/GJA5/RCAN1/CAV2/EGR1/GPC1/PPP3CA/KLF5/CSRP1/DDX17/TGFBR3/OBSL1 29 GO:0010506 regulation of autophagy 24/852 317/18722 0.0104781846577508 0.0644356833307937 QSOX1/TSPO/PSAP/TMEM59/HERC1/HSPB1/CTSA/PLK2/SH3BP4/MTDH/DAP/GBA/ATP6V0E1/DAPK1/EIF4G2/PINK1/PAFAH1B2/PIK3CB/MAPK3/CTTN/TP53/RHEB/SEC22B/SH3GLB1 24 GO:0045860 positive regulation of protein kinase activity 28/852 386/18722 0.0104853615433976 0.0644356833307937 IGF2/FLT1/FGFR1/SDC4/PRKAG2/ERBB2/TGFB1/GPRC5A/TGFB2/PTK2B/CSF1R/EFNA1/INSR/SASH1/BMPR2/TIAM1/ADAM9/DAG1/PINK1/TXN/EGR1/MAGED1/PTK2/ERBB3/PRRC1/IQGAP1/ADAM17/ERP29 28 GO:0045577 regulation of B cell differentiation 5/852 30/18722 0.0106630412480276 0.0652884265222906 SFRP1/INHA/XBP1/MMP14/ZFP36L1 5 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 5/852 30/18722 0.0106630412480276 0.0652884265222906 PLCL2/CBLB/DGKZ/LGALS3/EZR 5 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 5/852 30/18722 0.0106630412480276 0.0652884265222906 ABCA7/XBP1/WFS1/PPP1R15B/PIK3R1 5 GO:0061077 chaperone-mediated protein folding 8/852 67/18722 0.010817481899122 0.0661298545095881 FKBP11/P3H1/HSPB1/PPIB/ERO1A/PDIA4/HSPH1/SDF2L1 8 GO:0015850 organic hydroxy compound transport 22/852 284/18722 0.0108267435159747 0.0661298545095881 SYT8/SLC6A2/TSPO/POMC/APOC1/ABCA7/APOE/SCARB1/RALBP1/LIMA1/SLC16A3/ACTB/ABCA1/NPC2/LIPG/PINK1/LDLR/LRP1/RXRA/FURIN/ARL8B/SLC16A1 22 GO:0016051 carbohydrate biosynthetic process 17/852 202/18722 0.0110393625551718 0.0673468021093087 IGF2/B3GNT7/TGFB1/PHKG1/PTK2B/B4GALT1/FAM3C/INSR/MGAT2/ATF3/PPP1CB/ST3GAL6/B4GALT5/DDB1/EXT2/ATF4/IMPA2 17 GO:0051817 modulation of process of other organism involved in symbiotic interaction 9/852 81/18722 0.0111857044600055 0.068156961921559 IFI27/APOE/INSR/PPIB/DAG1/CAV2/IGF2R/RXRA/FMR1 9 GO:1904951 positive regulation of establishment of protein localization 24/852 319/18722 0.0112591340545612 0.0683972764869782 TCF7L2/ERBB2/SMAD3/CAMK2N1/TGFB1/TGFB2/SOX4/FLNA/RHOU/ADAM9/TMED10/PINK1/ACSL4/LRP1/SAR1A/EZR/JUP/PIK3R1/GOLPH3/MYO1C/ACSL3/SH3GLB1/SRI/FRMD4A 24 GO:0000413 protein peptidyl-prolyl isomerization 6/852 42/18722 0.0112930929387401 0.0683972764869782 FKBP10/FKBP11/PPIC/FKBP9/PPIB/FKBP14 6 GO:0007520 myoblast fusion 6/852 42/18722 0.0112930929387401 0.0683972764869782 ADAM12/CD9/GDF15/JAM2/MYH9/CAPN2 6 GO:0019432 triglyceride biosynthetic process 6/852 42/18722 0.0112930929387401 0.0683972764869782 LPL/MFSD2A/SCARB1/LDLR/ACSL4/CTDNEP1 6 GO:2001222 regulation of neuron migration 6/852 42/18722 0.0112930929387401 0.0683972764869782 PLXNB2/FLNA/SRGAP2C/SRGAP2/ARHGEF2/MDK 6 GO:0061448 connective tissue development 20/852 252/18722 0.0114660148774908 0.0693301600187849 BGN/NOG/TIMP1/ACVRL1/SMAD3/COL27A1/SH3PXD2B/TGFB1/SERPINH1/BMP1/XBP1/LTBP3/BMPR2/CREB3L2/CTNNB1/EGR1/PGRMC2/MAPK3/MYCN/MDK 20 GO:0006700 C21-steroid hormone biosynthetic process 4/852 20/18722 0.0115159971737938 0.0693301600187849 ADM/TSPO/CYP11A1/EGR1 4 GO:0043691 reverse cholesterol transport 4/852 20/18722 0.0115159971737938 0.0693301600187849 APOE/SCARB1/ABCA1/LIPG 4 GO:0051004 regulation of lipoprotein lipase activity 4/852 20/18722 0.0115159971737938 0.0693301600187849 APOC1/ANGPTL4/PCSK6/FURIN 4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/852 20/18722 0.0115159971737938 0.0693301600187849 XBP1/WFS1/HERPUD1/TMBIM6 4 GO:0030177 positive regulation of Wnt signaling pathway 13/852 140/18722 0.0115397781374447 0.0693903266018626 SFRP1/SEMA5A/SMAD3/TGFB1/SOX4/TNFAIP3/TNKS2/MBD2/SPIN1/XIAP/JUP/CTDNEP1/MACF1 13 GO:0009313 oligosaccharide catabolic process 3/852 11/18722 0.0117773156828571 0.0697843592121442 HEXB/GM2A/NEU1 3 GO:0019048 modulation by virus of host process 3/852 11/18722 0.0117773156828571 0.0697843592121442 INSR/DAG1/RXRA 3 GO:0032329 serine transport 3/852 11/18722 0.0117773156828571 0.0697843592121442 SFXN3/SLC1A5/SERINC3 3 GO:0034379 very-low-density lipoprotein particle assembly 3/852 11/18722 0.0117773156828571 0.0697843592121442 APOC1/MFSD2A/ACSL3 3 GO:0035581 sequestering of extracellular ligand from receptor 3/852 11/18722 0.0117773156828571 0.0697843592121442 LTBP1/FBN1/FBN2 3 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 3/852 11/18722 0.0117773156828571 0.0697843592121442 TMED2/PPP1R15B/DNAJC3 3 GO:0071492 cellular response to UV-A 3/852 11/18722 0.0117773156828571 0.0697843592121442 TIMP1/MMP2/OPN3 3 GO:0072497 mesenchymal stem cell differentiation 3/852 11/18722 0.0117773156828571 0.0697843592121442 LTBP3/CTNNB1/KRT18 3 GO:0097050 type B pancreatic cell apoptotic process 3/852 11/18722 0.0117773156828571 0.0697843592121442 TCF7L2/WFS1/SRSF6 3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 3/852 11/18722 0.0117773156828571 0.0697843592121442 ATF3/TP53/ATF4 3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 3/852 11/18722 0.0117773156828571 0.0697843592121442 PRKAG2/PKIG/PRKAR2A 3 GO:0032922 circadian regulation of gene expression 8/852 68/18722 0.011785556393865 0.0697843592121442 NRIP1/ID3/GFPT1/EGR1/PPP1CB/MAGED1/ID1/ATF4 8 GO:1900046 regulation of hemostasis 8/852 68/18722 0.011785556393865 0.0697843592121442 SERPINE2/SERPINE1/SERPING1/TFPI/CD9/APOE/EPHB2/UBASH3B 8 GO:0015914 phospholipid transport 10/852 96/18722 0.0119341962579177 0.0704022795127986 APOC1/ABCA7/APOE/MFSD2A/ATP11A/SCARB1/ABCA1/NPC2/SCARB2/LDLR 10 GO:0042632 cholesterol homeostasis 10/852 96/18722 0.0119341962579177 0.0704022795127986 LPL/APOE/SCARB1/XBP1/LIMA1/INSIG1/ABCA1/NPC2/LIPG/LDLR 10 GO:0001755 neural crest cell migration 7/852 55/18722 0.0119458666210868 0.0704022795127986 FN1/SEMA5A/EFNB1/EDNRB/SEMA4C/LAMA5/SEMA7A 7 GO:1902991 regulation of amyloid precursor protein catabolic process 7/852 55/18722 0.0119458666210868 0.0704022795127986 ABCA7/APOE/EFNA1/PICALM/RTN4/TMED10/RTN2 7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 9/852 82/18722 0.0120735166509202 0.0709054951039457 TIMP3/SERPINE1/SFRP1/TNFAIP3/ARHGEF2/ATF3/PEA15/LGALS3/PIK3R1 9 GO:0046889 positive regulation of lipid biosynthetic process 9/852 82/18722 0.0120735166509202 0.0709054951039457 ADM/APOE/MFSD2A/SCARB1/LDLR/CAPN2/RDH10/CTDNEP1/ACSL3 9 GO:0060395 SMAD protein signal transduction 9/852 82/18722 0.0120735166509202 0.0709054951039457 GDF15/SMAD3/WWTR1/TGFB1/TGFB2/INHA/BMPR2/LRP1/RBPMS 9 GO:0007219 Notch signaling pathway 15/852 172/18722 0.0120980379609856 0.0709666958713756 IL6ST/KRT19/GATA2/TGFB2/NOTCH2/MMP14/ADAM10/ANXA4/TSPAN14/DTX4/SEL1L/NCSTN/EPN2/ADAM17/MAML2 15 GO:0010038 response to metal ion 27/852 373/18722 0.012115083584471 0.0709839530624474 AOC1/FSTL3/SPARC/PTGES/SYT8/TSPO/PAM/MT1X/SLC30A2/PTK2B/ENDOG/SOD3/CLIC4/CALR/SDC1/ADAM9/SEC31A/ADCY7/CUTA/NDRG1/FOSB/MAPK3/IQGAP1/PPP3CA/BSG/P2RX4/NCSTN 27 GO:0030149 sphingolipid catabolic process 5/852 31/18722 0.0122484109992166 0.0713498293507609 HEXB/GM2A/GBA/HEXA/NEU1 5 GO:0048384 retinoic acid receptor signaling pathway 5/852 31/18722 0.0122484109992166 0.0713498293507609 CALR/DHRS3/CTBP2/ACTN4/RXRA 5 GO:0048710 regulation of astrocyte differentiation 5/852 31/18722 0.0122484109992166 0.0713498293507609 SERPINE2/IL6ST/NOG/LDLR/MYCN 5 GO:0060390 regulation of SMAD protein signal transduction 5/852 31/18722 0.0122484109992166 0.0713498293507609 WWTR1/TGFB1/BMPR2/LRP1/RBPMS 5 GO:0070633 transepithelial transport 5/852 31/18722 0.0122484109992166 0.0713498293507609 CLDN19/SLC23A2/EDNRB/ACTB/SLC1A3 5 GO:0007034 vacuolar transport 14/852 157/18722 0.0125437808689929 0.0729859527325332 PSAP/GRN/SCARB2/AP3S1/LAMP1/PINK1/TMEM50A/LRP1/IGF2R/NDFIP2/ARL8B/AP1G1/NDFIP1/LAMP2 14 GO:0046651 lymphocyte proliferation 22/852 288/18722 0.0125873041147069 0.0731546207959814 IGF2/EBI3/IL6ST/HLA-G/PLCL2/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/CD151/ELF4/PKN1/CBLB/CD320/CTNNB1/LGALS3/MIF/TP53/NDFIP1/NCSTN 22 GO:0010171 body morphogenesis 6/852 43/18722 0.0126326559895 0.0731647383143306 NOG/MMP2/CRISPLD2/PHLDB2/DAG1/PLEKHA1 6 GO:0071604 transforming growth factor beta production 6/852 43/18722 0.0126326559895 0.0731647383143306 FN1/LTBP1/SMAD3/TGFB2/LTBP3/FURIN 6 GO:0120178 steroid hormone biosynthetic process 6/852 43/18722 0.0126326559895 0.0731647383143306 ADM/HSD3B1/TSPO/SCARB1/CYP11A1/EGR1 6 GO:0010469 regulation of signaling receptor activity 15/852 173/18722 0.0127094538136065 0.0734405063649614 SERPINE1/NOG/ITGB1/IL18BP/RASGRF2/GPRC5A/PTK2B/EPHB2/IFNGR2/DLGAP4/CBLB/DAPK1/PINK1/ERRFI1/ADAM17 15 GO:0051099 positive regulation of binding 15/852 173/18722 0.0127094538136065 0.0734405063649614 TCF7L2/GATA3/PLCL2/TGFB1/APOE/PLK2/TIAM1/CTNNB1/CTBP2/TXN/CLN5/LRP1/MBD2/AMFR/FMR1 15 GO:0055092 sterol homeostasis 10/852 97/18722 0.012781335175408 0.0736866665954506 LPL/APOE/SCARB1/XBP1/LIMA1/INSIG1/ABCA1/NPC2/LIPG/LDLR 10 GO:1901216 positive regulation of neuron death 10/852 97/18722 0.012781335175408 0.0736866665954506 ITGA1/TGFB2/GRN/CTNNB1/PICALM/CTSZ/EGR1/CAPN2/TP53/ATF4 10 GO:0033344 cholesterol efflux 8/852 69/18722 0.0128158945968025 0.0737170257208079 APOC1/ABCA7/APOE/SCARB1/ABCA1/NPC2/LRP1/RXRA 8 GO:1904377 positive regulation of protein localization to cell periphery 8/852 69/18722 0.0128158945968025 0.0737170257208079 ITGB1/ARHGEF16/EPHB2/LRP1/LGALS3/EZR/PIK3R1/ACSL3 8 GO:0043547 positive regulation of GTPase activity 20/852 255/18722 0.0129269327570289 0.0741861488781372 ITGB1/SFRP1/F11R/ASAP3/ERBB2/IQSEC1/SYDE1/PTK2B/MAPRE2/ARHGEF16/RALBP1/SRGAP2/TIAM1/PICALM/CAV2/TBC1D10A/BCAR3/ARHGAP29/ARHGEF7/SGSM3 20 GO:1903362 regulation of cellular protein catabolic process 20/852 255/18722 0.0129269327570289 0.0741861488781372 PTK2B/APOE/EFNA1/TNFAIP3/PLK2/GBA/PINK1/LDLR/ANKIB1/PTK2/LRP1/HERPUD1/RNF144B/RNF139/FURIN/CSNK1A1/EZR/UBE2K/FMR1/TMEM259 20 GO:0000302 response to reactive oxygen species 18/852 222/18722 0.0130171061333724 0.0746185594182954 TPM1/IL18BP/MMP2/PXN/PYCR1/PTK2B/APOE/ENDOG/SOD3/TNFAIP3/SDC1/ADAM9/PINK1/PLEKHA1/TXN/MAPK3/CAPN2/PPP1R15B 18 GO:0048863 stem cell differentiation 17/852 206/18722 0.0132215484204217 0.0757042698520846 FN1/SFRP1/CITED2/PTN/SEMA5A/EFNB1/TGFB2/EDNRB/SEMA4C/LTBP3/CTNNB1/LAMA5/SEMA7A/MAPK3/RDH10/TP53/KRT18 17 GO:0051216 cartilage development 16/852 190/18722 0.0133390624233067 0.0762903422460259 BGN/NOG/TIMP1/ACVRL1/SMAD3/COL27A1/TGFB1/SERPINH1/BMP1/LTBP3/BMPR2/CREB3L2/CTNNB1/MAPK3/MYCN/MDK 16 GO:0003177 pulmonary valve development 4/852 21/18722 0.0137234319626493 0.0777815687702859 TGFB2/NOTCH2/BMPR2/GJA5 4 GO:0044766 multi-organism transport 4/852 21/18722 0.0137234319626493 0.0777815687702859 CTSL/BST2/CAV2/FMR1 4 GO:0045056 transcytosis 4/852 21/18722 0.0137234319626493 0.0777815687702859 MFSD2A/PICALM/LRP1/USO1 4 GO:0048714 positive regulation of oligodendrocyte differentiation 4/852 21/18722 0.0137234319626493 0.0777815687702859 PTN/DAG1/MDK/RHEB 4 GO:0060445 branching involved in salivary gland morphogenesis 4/852 21/18722 0.0137234319626493 0.0777815687702859 NTN4/DAG1/LAMA5/BTBD7 4 GO:0099515 actin filament-based transport 4/852 21/18722 0.0137234319626493 0.0777815687702859 MYO6/ACTN4/SUN2/MYO1C 4 GO:1902579 multi-organism localization 4/852 21/18722 0.0137234319626493 0.0777815687702859 CTSL/BST2/CAV2/FMR1 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/852 21/18722 0.0137234319626493 0.0777815687702859 PTN/GATA2/TP53/SPINT1 4 GO:0005996 monosaccharide metabolic process 20/852 257/18722 0.0139802885711989 0.0788268375973073 IGF2/POMC/SLC23A2/GAA/B4GALT1/FAM3C/MAN2A1/INSR/ATF3/H6PD/FABP5/PPP1CB/FUCA2/INPPL1/TP53/DDB1/GLB1/GALE/ATF4/UXS1 20 GO:0021799 cerebral cortex radially oriented cell migration 5/852 32/18722 0.0139861645091189 0.0788268375973073 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0046475 glycerophospholipid catabolic process 5/852 32/18722 0.0139861645091189 0.0788268375973073 APOC1/PLA2G7/GDPD3/SCARB1/LDLR 5 GO:0061036 positive regulation of cartilage development 5/852 32/18722 0.0139861645091189 0.0788268375973073 ACVRL1/SMAD3/BMP1/BMPR2/MDK 5 GO:1901185 negative regulation of ERBB signaling pathway 5/852 32/18722 0.0139861645091189 0.0788268375973073 ITGA1/GPRC5A/CBLB/PTPN3/ERRFI1 5 GO:0010921 regulation of phosphatase activity 9/852 84/18722 0.0140052939096941 0.0788463582186694 MGAT5/ITGA1/SMAD3/NUAK1/TGFB2/HSP90B1/RCAN1/LGALS3/PPP1R15B 9 GO:0032943 mononuclear cell proliferation 22/852 291/18722 0.0140521321622817 0.0790008380336107 IGF2/EBI3/IL6ST/HLA-G/PLCL2/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/CD151/ELF4/PKN1/CBLB/CD320/CTNNB1/LGALS3/MIF/TP53/NDFIP1/NCSTN 22 GO:0060324 face development 6/852 44/18722 0.0140798235080765 0.0790008380336107 NOG/MMP2/CRISPLD2/GRHL2/PLEKHA1/MAPK3 6 GO:1903573 negative regulation of response to endoplasmic reticulum stress 6/852 44/18722 0.0140798235080765 0.0790008380336107 ABCA7/XBP1/WFS1/HERPUD1/PPP1R15B/TMBIM6 6 GO:0070997 neuron death 26/852 361/18722 0.0144616056611143 0.0810526295015457 EGLN3/GATA3/ITGA1/TGFB2/SLC23A2/PTK2B/APOE/ENDOG/GRN/PIGT/WFS1/CTNNB1/GBA/PICALM/PINK1/CTSZ/EGR1/ERBB3/LRP1/CAPN2/TP53/XIAP/MDK/NCSTN/ATF4/TMEM259 26 GO:0030838 positive regulation of actin filament polymerization 10/852 99/18722 0.0146102368598214 0.081794574099534 PTK2B/BAIAP2L1/CDC42EP5/VASP/NCKAP1/CDC42EP1/EVL/CTTN/GSN/MYO1C 10 GO:0021987 cerebral cortex development 11/852 114/18722 0.0147942953953003 0.0827329874717183 PTPRS/FLNA/SRGAP2C/SRGAP2/CTNNB1/RTN4/NCOA1/LRP1/SUN2/MDK/TACC1 11 GO:0001656 metanephros development 9/852 85/18722 0.0150526277247371 0.0834931010328079 FBN1/GATA3/WWTR1/ID3/LAMB2/CTNNB1/EGR1/RDH10/CTSH 9 GO:0010507 negative regulation of autophagy 9/852 85/18722 0.0150526277247371 0.0834931010328079 QSOX1/TSPO/HERC1/CTSA/DAP/EIF4G2/PINK1/TP53/SEC22B 9 GO:0003281 ventricular septum development 8/852 71/18722 0.0150720601064706 0.0834931010328079 NOG/CITED2/GATA3/TGFB2/SOX4/BMPR2/GJA5/TGFBR3 8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 3/852 12/18722 0.0151790557212436 0.0834931010328079 COL4A2/COL4A1/UBASH3B 3 GO:0043471 regulation of cellular carbohydrate catabolic process 3/852 12/18722 0.0151790557212436 0.0834931010328079 SCARB2/PPP1CB/TP53 3 GO:0051549 positive regulation of keratinocyte migration 3/852 12/18722 0.0151790557212436 0.0834931010328079 IQSEC1/MAPRE2/ADAM9 3 GO:0061430 bone trabecula morphogenesis 3/852 12/18722 0.0151790557212436 0.0834931010328079 SFRP1/MMP2/FBN2 3 GO:0072015 glomerular visceral epithelial cell development 3/852 12/18722 0.0151790557212436 0.0834931010328079 NOTCH2/LAMB2/IQGAP1 3 GO:0072182 regulation of nephron tubule epithelial cell differentiation 3/852 12/18722 0.0151790557212436 0.0834931010328079 GATA3/WWTR1/CTNNB1 3 GO:0072376 protein activation cascade 3/852 12/18722 0.0151790557212436 0.0834931010328079 FN1/FBLN1/PRCP 3 GO:0090331 negative regulation of platelet aggregation 3/852 12/18722 0.0151790557212436 0.0834931010328079 SERPINE2/CD9/UBASH3B 3 GO:0090557 establishment of endothelial intestinal barrier 3/852 12/18722 0.0151790557212436 0.0834931010328079 F11R/PTPRS/TJP2 3 GO:0098911 regulation of ventricular cardiac muscle cell action potential 3/852 12/18722 0.0151790557212436 0.0834931010328079 PKP2/DSG2/JUP 3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 3/852 12/18722 0.0151790557212436 0.0834931010328079 TGFB1/MYCN/TP53 3 GO:2001204 regulation of osteoclast development 3/852 12/18722 0.0151790557212436 0.0834931010328079 FBN1/NOTCH2/ATP6AP1 3 GO:0003197 endocardial cushion development 6/852 45/18722 0.0156385738442944 0.0859267927492725 ENG/NOG/CITED2/ACVRL1/TGFB2/BMPR2 6 GO:0050866 negative regulation of cell activation 17/852 210/18722 0.0157285973430066 0.0860887401164571 SERPINE2/HLA-G/SFRP1/CD9/SDC4/ERBB2/APOE/INHA/GRN/TNFAIP3/PKN1/CBLB/UBASH3B/LDLR/LGALS3/NDFIP1/MDK 17 GO:0001954 positive regulation of cell-matrix adhesion 7/852 58/18722 0.0157535723519287 0.0860887401164571 SFRP1/SDC4/SMAD3/PTK2B/DAG1/IQGAP1/JUP 7 GO:0010559 regulation of glycoprotein biosynthetic process 7/852 58/18722 0.0157535723519287 0.0860887401164571 ITM2B/TCF7L2/ABCA7/TMEM59/CTNNB1/ITM2C/NCSTN 7 GO:0043525 positive regulation of neuron apoptotic process 7/852 58/18722 0.0157535723519287 0.0860887401164571 ITGA1/TGFB2/GRN/CTNNB1/CTSZ/TP53/ATF4 7 GO:0043666 regulation of phosphoprotein phosphatase activity 7/852 58/18722 0.0157535723519287 0.0860887401164571 MGAT5/ITGA1/NUAK1/HSP90B1/RCAN1/LGALS3/PPP1R15B 7 GO:0048048 embryonic eye morphogenesis 5/852 33/18722 0.0158821660914585 0.086697333989491 MFAP5/FBN1/CITED2/MFAP2/FBN2 5 GO:0002089 lens morphogenesis in camera-type eye 4/852 22/18722 0.0161819932962505 0.0877629011422725 CITED2/CTNNB1/BCAR3/ATF4 4 GO:0010866 regulation of triglyceride biosynthetic process 4/852 22/18722 0.0161819932962505 0.0877629011422725 MFSD2A/SCARB1/LDLR/CTDNEP1 4 GO:0035357 peroxisome proliferator activated receptor signaling pathway 4/852 22/18722 0.0161819932962505 0.0877629011422725 CITED2/FABP5/ACTN4/RXRA 4 GO:0050860 negative regulation of T cell receptor signaling pathway 4/852 22/18722 0.0161819932962505 0.0877629011422725 CBLB/DGKZ/LGALS3/EZR 4 GO:0140467 integrated stress response signaling 4/852 22/18722 0.0161819932962505 0.0877629011422725 ABCA7/TMED2/PPP1R15B/ATF4 4 GO:1900120 regulation of receptor binding 4/852 22/18722 0.0161819932962505 0.0877629011422725 PTPRF/NOG/PLCL2/ADAM15 4 GO:0000271 polysaccharide biosynthetic process 8/852 72/18722 0.0163021654072211 0.0883194816948801 IGF2/B3GNT7/TGFB1/PHKG1/INSR/PPP1CB/B4GALT5/EXT2 8 GO:0021782 glial cell development 11/852 116/18722 0.0166684744890221 0.0902069162400517 CD9/SOX4/GRN/LAMB2/DAG1/LDLR/NDRG1/LRP1/B4GALT5/MDK/NCSTN 11 GO:0051258 protein polymerization 22/852 296/18722 0.016791302192277 0.0907740321522345 COTL1/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/MAP7D3/VASP/NCKAP1/PINK1/CDC42EP1/EVL/CTTN/GPX4/SSH2/TTC17/ARHGEF7/GSN/UBE2K/MYO1C 22 GO:0001936 regulation of endothelial cell proliferation 15/852 179/18722 0.0168988755556583 0.0911097435791573 IGF2/FLT1/SPARC/FGFR1/ACVRL1/SEMA5A/GATA2/APOE/PGF/BMPR2/CAV2/MYDGF/MDK/ADAM17/EMC10 15 GO:0010466 negative regulation of peptidase activity 20/852 262/18722 0.0169114992283852 0.0911097435791573 SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/PCSK1N/SERPINH1/CRIM1/PICALM/TMED10/BST2/LRP1/HERPUD1/FURIN/XIAP/SPINT1/SERPINB6 20 GO:0031330 negative regulation of cellular catabolic process 20/852 262/18722 0.0169114992283852 0.0911097435791573 TIMP3/QSOX1/TIMP2/TIMP1/TSPO/APOC1/MFSD2A/HERC1/EFNA1/CTSA/DAP/PABPC1/EIF4G2/PINK1/FURIN/TP53/SEC22B/PTPN3/FMR1/PKP3 20 GO:0006633 fatty acid biosynthetic process 14/852 163/18722 0.0169439141645323 0.0911097435791573 PTGES/PRKAG2/APOC1/LPL/XBP1/FADS3/INSIG1/TECR/MGLL/LIPG/FABP5/MIF/GPX4/ACSL3 14 GO:0010976 positive regulation of neuron projection development 14/852 163/18722 0.0169439141645323 0.0911097435791573 PTN/PLXNB2/PTK2B/APOE/FLNA/GRN/P3H1/CREB3L2/SCARB2/TIAM1/LRP1/IQGAP1/NPTN/MDK 14 GO:0043523 regulation of neuron apoptotic process 17/852 212/18722 0.0171132649156122 0.0919221582927174 EGLN3/GATA3/ITGA1/TGFB2/PTK2B/APOE/GRN/WFS1/CTNNB1/GBA/PINK1/CTSZ/ERBB3/LRP1/TP53/MDK/ATF4 17 GO:0046324 regulation of glucose import 7/852 59/18722 0.0171947095731862 0.092045817188354 PRKAG2/ASPSCR1/INSR/PEA15/OPN3/PIK3R1/RTN2 7 GO:0048010 vascular endothelial growth factor receptor signaling pathway 7/852 59/18722 0.0171947095731862 0.092045817188354 FLT1/ITGA5/PTK2B/PGF/HSPB1/PTK2/EPN2 7 GO:2000351 regulation of endothelial cell apoptotic process 7/852 59/18722 0.0171947095731862 0.092045817188354 SERPINE1/HLA-G/GATA3/SEMA5A/GATA2/ANGPTL4/TNFAIP3 7 GO:0046394 carboxylic acid biosynthetic process 23/852 314/18722 0.0172094404876299 0.092045817188354 PTGES/PLOD3/PLOD2/PRKAG2/APOC1/LPL/PYCR1/UGDH/XBP1/FADS3/INSIG1/TECR/MGLL/LIPG/FABP5/GLS/MIF/GPX4/SERINC3/RDH10/SLC1A3/BCAT1/ACSL3 23 GO:0001974 blood vessel remodeling 6/852 46/18722 0.0173127365524777 0.0922370136984884 BGN/EPAS1/ACVRL1/TGFB1/FLNA/BMPR2 6 GO:0034198 cellular response to amino acid starvation 6/852 46/18722 0.0173127365524777 0.0922370136984884 GCN1/ATF3/DAP/MAPK3/ATF4/SH3GLB1 6 GO:0061028 establishment of endothelial barrier 6/852 46/18722 0.0173127365524777 0.0922370136984884 F11R/PTPRS/MYADM/EZR/TJP2/VCL 6 GO:0150104 transport across blood-brain barrier 9/852 87/18722 0.0173184935317051 0.0922370136984884 SLC7A1/APOE/MFSD2A/INSR/SLC1A5/FABP5/LRP1/SLC1A3/SLC16A1 9 GO:0003018 vascular process in circulatory system 20/852 263/18722 0.0175515514021214 0.0932592676979644 ADM/DOCK5/PLOD3/ITGA1/TGFB1/SLC7A1/APOE/MFSD2A/EDNRB/SOD3/INSR/SLC1A5/BMPR2/GJA5/FABP5/LRP1/TJP2/SLC1A3/EXT2/SLC16A1 20 GO:0043588 skin development 20/852 263/18722 0.0175515514021214 0.0932592676979644 FLNB/TGFB2/UGCG/FOSL2/PALLD/CLIC4/GRHL2/SGPP1/ADAM9/CTNNB1/GBA/LAMA5/ZFP36L1/OPN3/SRSF6/LSR/JUP/KRT10/ERRFI1/GRHL1 20 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 8/852 73/18722 0.0176030805311079 0.0932592676979644 ITGA1/GPRC5A/HIP1/CBLB/BCAR3/PTPN3/ERRFI1/ADAM17 8 GO:0061035 regulation of cartilage development 8/852 73/18722 0.0176030805311079 0.0932592676979644 NOG/ACVRL1/SMAD3/BMP1/LTBP3/BMPR2/CTNNB1/MDK 8 GO:0086003 cardiac muscle cell contraction 8/852 73/18722 0.0176030805311079 0.0932592676979644 KCNJ2/FLNA/PKP2/DSG2/GJA5/JUP/GSN/SRI 8 GO:1903828 negative regulation of cellular protein localization 11/852 117/18722 0.0176695060565091 0.0935127486670981 TGFB1/TMEM59/ANKRD13A/OS9/INSIG1/LMAN1/PICALM/TXN/PKIG/MAGED1/LYPLA1 11 GO:0006672 ceramide metabolic process 10/852 102/18722 0.0177102664437251 0.0936300115664587 HEXB/UGCG/SGMS2/GM2A/PLPP3/GBA/CERS6/HEXA/B4GALT5/NEU1 10 GO:0043583 ear development 17/852 213/18722 0.0178400253020848 0.0942170486310524 SPARC/NOG/GATA3/SLC4A7/SDC4/GATA2/TGFB2/EPHB2/INSIG1/ADAM10/LRP10/NAGLU/MYCL/MAPK3/MYO6/MYCN/RDH10 17 GO:0050869 negative regulation of B cell activation 5/852 34/18722 0.0179419046942128 0.0946557718301606 SFRP1/INHA/TNFAIP3/PKN1/NDFIP1 5 GO:0048511 rhythmic process 22/852 298/18722 0.0179979261929161 0.0948518979360699 NRIP1/PTN/ADAMTS1/PAM/TGFB2/ID3/NCOR2/GFPT1/NCOA1/PLEKHA1/NAGLU/EGR1/OPN3/PPP1CB/MAGED1/KLF10/TP53/DDB1/GNAQ/MDK/ID1/ATF4 22 GO:0072594 establishment of protein localization to organelle 29/852 422/18722 0.0183204212983487 0.0964505025048002 TSPO/SMAD3/TGFB1/FLNA/RHOU/RAB8B/TNFAIP3/SCARB2/CBLB/LMAN1/SEC61A1/SSR3/LAMP1/PINK1/PKIG/SEC61G/HERPUD1/SEC62/PPP3CA/TRAM2/TP53/JUP/TRAM1/PIK3R1/SPCS3/LAMP2/SEC63/IPO7/SH3GLB1 29 GO:0016053 organic acid biosynthetic process 23/852 316/18722 0.0184015559740254 0.0967764171549321 PTGES/PLOD3/PLOD2/PRKAG2/APOC1/LPL/PYCR1/UGDH/XBP1/FADS3/INSIG1/TECR/MGLL/LIPG/FABP5/GLS/MIF/GPX4/SERINC3/RDH10/SLC1A3/BCAT1/ACSL3 23 GO:0008361 regulation of cell size 15/852 181/18722 0.0185080742862171 0.0972350082281113 FN1/SEMA5A/CRABP2/PTPRS/SLC12A8/APOE/SEMA4C/BMPR2/DNM2/RTN4/EIF4G2/LRP1/SEMA7A/CTTN/MACF1 15 GO:0010232 vascular transport 9/852 88/18722 0.0185402897229817 0.0973026884001741 SLC7A1/APOE/MFSD2A/INSR/SLC1A5/FABP5/LRP1/SLC1A3/SLC16A1 9 GO:0009411 response to UV 13/852 149/18722 0.0185936487308369 0.0973796400232074 PTN/TIMP1/MMP2/SCARA3/SDF4/OPN3/TP53/DDB1/PIK3R1/TP53I13/FMR1/ATF4/UBE2A 13 GO:0051592 response to calcium ion 13/852 149/18722 0.0185936487308369 0.0973796400232074 SPARC/PTGES/SYT8/PTK2B/ENDOG/CLIC4/SDC1/ADAM9/SEC31A/FOSB/IQGAP1/PPP3CA/NCSTN 13 GO:0006893 Golgi to plasma membrane transport 7/852 60/18722 0.0187263575998979 0.097426944798216 DNM2/SEC16A/LYPLA1/GOLPH3/KRT18/ACSL3/MACF1 7 GO:0055008 cardiac muscle tissue morphogenesis 7/852 60/18722 0.0187263575998979 0.097426944798216 TPM1/ENG/NOG/TGFB1/TGFB2/PKP2/TGFBR3 7 GO:0061951 establishment of protein localization to plasma membrane 7/852 60/18722 0.0187263575998979 0.097426944798216 SEC16A/LYPLA1/GOLPH3/KRT18/GORASP2/ACSL3/MACF1 7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 4/852 23/18722 0.0188996550255043 0.097426944798216 CHPF/UGDH/CHPF2/DSE 4 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 4/852 23/18722 0.0188996550255043 0.097426944798216 GDF15/GCM1/ADAM9/CAPN2 4 GO:0090208 positive regulation of triglyceride metabolic process 4/852 23/18722 0.0188996550255043 0.097426944798216 MFSD2A/SCARB1/LDLR/CTDNEP1 4 GO:1903201 regulation of oxidative stress-induced cell death 8/852 74/18722 0.0189768514425377 0.097426944798216 P4HB/PYCR1/ENDOG/HSPB1/CTNNB1/PINK1/TXN/ATF4 8 GO:0003334 keratinocyte development 3/852 13/18722 0.0190759116587501 0.097426944798216 FLNB/FOSL2/PALLD 3 GO:0010755 regulation of plasminogen activation 3/852 13/18722 0.0190759116587501 0.097426944798216 SERPINE2/SERPINE1/CTSZ 3 GO:0034112 positive regulation of homotypic cell-cell adhesion 3/852 13/18722 0.0190759116587501 0.097426944798216 IL6ST/F11R/JAK1 3 GO:0048207 vesicle targeting, rough ER to cis-Golgi 3/852 13/18722 0.0190759116587501 0.097426944798216 TMED2/TMED10/SAR1A 3 GO:0048208 COPII vesicle coating 3/852 13/18722 0.0190759116587501 0.097426944798216 TMED2/TMED10/SAR1A 3 GO:0048266 behavioral response to pain 3/852 13/18722 0.0190759116587501 0.097426944798216 TSPO/CAPN2/P2RX4 3 GO:0060347 heart trabecula formation 3/852 13/18722 0.0190759116587501 0.097426944798216 ADAMTS1/FHL2/TGFBR3 3 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 3/852 13/18722 0.0190759116587501 0.097426944798216 CITED2/EGR1/TP53 3 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 3/852 13/18722 0.0190759116587501 0.097426944798216 TNFAIP3/SLC15A3/XIAP 3 GO:0072310 glomerular epithelial cell development 3/852 13/18722 0.0190759116587501 0.097426944798216 NOTCH2/LAMB2/IQGAP1 3 GO:1900115 extracellular regulation of signal transduction 3/852 13/18722 0.0190759116587501 0.097426944798216 LTBP1/FBN1/FBN2 3 GO:1900116 extracellular negative regulation of signal transduction 3/852 13/18722 0.0190759116587501 0.097426944798216 LTBP1/FBN1/FBN2 3 GO:1900121 negative regulation of receptor binding 3/852 13/18722 0.0190759116587501 0.097426944798216 PTPRF/NOG/ADAM15 3 GO:1903977 positive regulation of glial cell migration 3/852 13/18722 0.0190759116587501 0.097426944798216 TIAM1/LRP1/P2RX4 3 GO:0035850 epithelial cell differentiation involved in kidney development 6/852 47/18722 0.0191059794388713 0.097426944798216 GATA3/WWTR1/NOTCH2/LAMB2/CTNNB1/IQGAP1 6 GO:0042311 vasodilation 6/852 47/18722 0.0191059794388713 0.097426944798216 PLOD3/ITGA1/APOE/EDNRB/GJA5/EXT2 6 GO:0048483 autonomic nervous system development 6/852 47/18722 0.0191059794388713 0.097426944798216 FN1/GATA3/SOX4/EDNRB/NAV2/CTNNB1 6 GO:0050885 neuromuscular process controlling balance 6/852 47/18722 0.0191059794388713 0.097426944798216 HEXB/HERC1/GAA/GM2A/RBFOX2/SLC1A3 6 GO:0120163 negative regulation of cold-induced thermogenesis 6/852 47/18722 0.0191059794388713 0.097426944798216 PLCL2/TLE3/RHEB/ID1/ATF4/ADAM17 6 GO:0070665 positive regulation of leukocyte proliferation 13/852 150/18722 0.0195427186415655 0.0994165640828939 IGF2/EBI3/IL6ST/CD276/EFNB1/SLC7A1/EPHB2/CSF1R/CD320/BST2/PTK2/MIF/MAPK3 13 GO:0060538 skeletal muscle organ development 14/852 166/18722 0.0195434318599366 0.0994165640828939 IGF2/FLNB/CITED2/TGFB1/ATF3/CTNNB1/RCAN1/DAG1/CAV2/EGR1/GPC1/PPP3CA/KLF5/DDX17 14 GO:0032271 regulation of protein polymerization 18/852 232/18722 0.0195554139563014 0.0994165640828939 COTL1/TMSB10/CAPG/PTK2B/ESAM/BAIAP2L1/CDC42EP5/MYADM/VASP/NCKAP1/PINK1/CDC42EP1/EVL/CTTN/SSH2/ARHGEF7/GSN/MYO1C 18 GO:0007159 leukocyte cell-cell adhesion 26/852 371/18722 0.0197480947871435 0.100294814393232 IGF2/EBI3/IL6ST/HLA-G/CERCAM/ITGB1/GATA3/F11R/JAM2/SDC4/ERBB2/CD276/SLC39A8/EFNB1/SLC7A1/SOX4/XBP1/CBLB/LGALS3/EZR/NDFIP1/MDK/HSPH1/GOLPH3/NFAT5/DPP4 26 GO:0022409 positive regulation of cell-cell adhesion 21/852 284/18722 0.0201533557684433 0.102028136164849 FSTL3/IGF2/EBI3/IL6ST/HLA-G/ADAM19/CITED2/GATA3/F11R/CD276/EFNB1/SLC7A1/SOX4/XBP1/PLPP3/MYO10/JAK1/MDK/HSPH1/NFAT5/DPP4 21 GO:0010765 positive regulation of sodium ion transport 5/852 35/18722 0.020170473968612 0.102028136164849 PRSS8/GLRX/PKP2/DNM2/ACTN4 5 GO:0034405 response to fluid shear stress 5/852 35/18722 0.020170473968612 0.102028136164849 CITED2/PTK2B/ABCA1/ADAM9/P2RX4 5 GO:1905898 positive regulation of response to endoplasmic reticulum stress 5/852 35/18722 0.020170473968612 0.102028136164849 XBP1/HERPUD1/SERINC3/PIK3R1/TMEM259 5 GO:0034113 heterotypic cell-cell adhesion 7/852 61/18722 0.0203511312273479 0.102838597858676 ITGA5/ITGB1/MYADM/PARVA/PKP2/DSG2/JUP 7 GO:0033077 T cell differentiation in thymus 8/852 75/18722 0.0204254783856256 0.103110765009883 GATA3/ERBB2/CTNNB1/GBA/ZFP36L1/TP53/ADAM17/CLPTM1 8 GO:0055088 lipid homeostasis 14/852 167/18722 0.0204736341117546 0.103250301086634 RCN3/LPL/ANGPTL4/APOE/SCARB1/XBP1/LIMA1/INSIG1/ABCA1/NPC2/RTN4/ACOX1/LIPG/LDLR 14 GO:0043535 regulation of blood vessel endothelial cell migration 13/852 151/18722 0.0205277133933044 0.10341940090941 FGFR1/PRCP/ACVRL1/GATA2/TGFB1/APOE/HSPB1/EFNA1/PLK2/HDAC5/P2RX4/JUP/ADAM17 13 GO:0071902 positive regulation of protein serine/threonine kinase activity 16/852 200/18722 0.0207007260123037 0.104186754019924 IGF2/FLT1/FGFR1/ERBB2/TGFB1/PTK2B/CSF1R/INSR/SASH1/BMPR2/TIAM1/ADAM9/MAGED1/IQGAP1/ADAM17/ERP29 16 GO:0071901 negative regulation of protein serine/threonine kinase activity 11/852 120/18722 0.0209413427124262 0.105292485386255 SFRP1/PRKAG2/APOE/CDKN1C/TNFAIP3/GBA/PKIG/PIK3CB/PRKAR2A/HIPK3/IPO7 11 GO:0009895 negative regulation of catabolic process 23/852 320/18722 0.0209794069366405 0.105378597916279 SERPINE2/TIMP3/QSOX1/TIMP2/TIMP1/TSPO/APOC1/SMAD3/MFSD2A/FLNA/HERC1/EFNA1/CTSA/DAP/PABPC1/EIF4G2/PINK1/FURIN/TP53/SEC22B/PTPN3/FMR1/PKP3 23 GO:0033628 regulation of cell adhesion mediated by integrin 6/852 48/18722 0.0210217965980618 0.105381177567774 SERPINE1/TGFB2/EFNA1/ADAM9/PTK2/DPP4 6 GO:0042149 cellular response to glucose starvation 6/852 48/18722 0.0210217965980618 0.105381177567774 PRKAG2/NUAK1/XBP1/TP53/ATF4/SH3GLB1 6 GO:0002028 regulation of sodium ion transport 9/852 90/18722 0.0211695845201306 0.105911052574371 SERPINE2/PRSS8/FXYD5/GLRX/PKP2/DNM2/ACTN4/P2RX4/PTPN3 9 GO:0034644 cellular response to UV 9/852 90/18722 0.0211695845201306 0.105911052574371 PTN/TIMP1/MMP2/OPN3/TP53/DDB1/PIK3R1/FMR1/ATF4 9 GO:0030098 lymphocyte differentiation 26/852 374/18722 0.0215995784040284 0.107954993155387 HLA-G/ITGB1/SFRP1/GATA3/PLCL2/ERBB2/PTK2B/INHA/SOX4/CTSL/XBP1/NOTCH2/MMP14/CTNNB1/HDAC5/GBA/KLF6/ZFP36L1/EGR1/KDELR1/TP53/NDFIP1/MDK/PIK3R1/ADAM17/CLPTM1 26 GO:0003148 outflow tract septum morphogenesis 4/852 24/18722 0.0218832331023131 0.10848620875615 ENG/TGFB2/PARVA/BMPR2 4 GO:0003181 atrioventricular valve morphogenesis 4/852 24/18722 0.0218832331023131 0.10848620875615 TGFB2/SOX4/EFNA1/BMPR2 4 GO:0007035 vacuolar acidification 4/852 24/18722 0.0218832331023131 0.10848620875615 GRN/CLIC4/ATP6V0E1/CLN5 4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 4/852 24/18722 0.0218832331023131 0.10848620875615 GCN1/ATF3/TP53/ATF4 4 GO:0051000 positive regulation of nitric-oxide synthase activity 4/852 24/18722 0.0218832331023131 0.10848620875615 PTK2B/APOE/SCARB1/PIK3CB 4 GO:0071577 zinc ion transmembrane transport 4/852 24/18722 0.0218832331023131 0.10848620875615 SLC39A6/SLC30A2/SLC39A8/SLC39A7 4 GO:1903077 negative regulation of protein localization to plasma membrane 4/852 24/18722 0.0218832331023131 0.10848620875615 TGFB1/TMEM59/PICALM/LYPLA1 4 GO:2001026 regulation of endothelial cell chemotaxis 4/852 24/18722 0.0218832331023131 0.10848620875615 FGFR1/SEMA5A/HSPB1/P2RX4 4 GO:0010951 negative regulation of endopeptidase activity 19/852 252/18722 0.0219214135316918 0.10848620875615 SERPINE2/TIMP3/SERPINE1/TIMP2/SERPING1/TFPI/TIMP1/CST6/PCSK1N/SERPINH1/CRIM1/PICALM/TMED10/BST2/HERPUD1/FURIN/XIAP/SPINT1/SERPINB6 19 GO:0045017 glycerolipid biosynthetic process 19/852 252/18722 0.0219214135316918 0.10848620875615 LPL/LPCAT1/MFSD2A/SCARB1/PIGT/IPMK/FABP5/LDLR/ACSL4/DGKZ/PIK3CB/SLC44A2/CAPN2/INPPL1/PIK3R1/CTDNEP1/ACSL3/GPAA1/IMPA2 19 GO:0008203 cholesterol metabolic process 12/852 137/18722 0.0225340746858713 0.111090987576791 APOE/SCARB1/LIMA1/INSIG1/CYP11A1/ABCA1/NPC2/GBA/LDLR/RXRA/HDLBP/CYB5R3 12 GO:0002062 chondrocyte differentiation 10/852 106/18722 0.0225645726796084 0.111090987576791 ACVRL1/SMAD3/COL27A1/TGFB1/SERPINH1/LTBP3/BMPR2/CREB3L2/CTNNB1/MDK 10 GO:0008207 C21-steroid hormone metabolic process 5/852 36/18722 0.022572555551867 0.111090987576791 ADM/HSD3B1/TSPO/CYP11A1/EGR1 5 GO:0010762 regulation of fibroblast migration 5/852 36/18722 0.022572555551867 0.111090987576791 ITGB1/SDC4/TGFB1/PTK2/ARHGEF7 5 GO:0046466 membrane lipid catabolic process 5/852 36/18722 0.022572555551867 0.111090987576791 HEXB/GM2A/GBA/HEXA/NEU1 5 GO:0001657 ureteric bud development 9/852 91/18722 0.0225801868251653 0.111090987576791 NOG/SFRP1/GATA3/SDC4/SMAD3/SDC1/CTNNB1/LAMA5/MAGED1 9 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28/852 412/18722 0.0229481474309893 0.112697653107617 IFI27/WWTR1/OS9/WFS1/PLK2/CANX/CALR/HSP90B1/CTNNB1/GBA/ANKIB1/LTN1/FAM8A1/ASCC2/HERPUD1/RNF144B/MAN1B1/ANKRD9/SEL1L/CSNK1A1/DNAJC10/DDB1/STT3B/AMFR/EDEM3/UBE2K/UBE2A/PCBP2 28 GO:0008038 neuron recognition 6/852 49/18722 0.0230634974569532 0.112697653107617 SEMA5A/EPHB2/PALLD/RTN4/BSG/NPTN 6 GO:0009395 phospholipid catabolic process 6/852 49/18722 0.0230634974569532 0.112697653107617 APOC1/PLA2G7/GDPD3/SCARB1/LIPG/LDLR 6 GO:0021695 cerebellar cortex development 6/852 49/18722 0.0230634974569532 0.112697653107617 SERPINE2/HERC1/GBA/NAGLU/ARCN1/MDK 6 GO:0038084 vascular endothelial growth factor signaling pathway 6/852 49/18722 0.0230634974569532 0.112697653107617 FLT1/CD63/PGF/HSPB1/PIK3CB/MYO1C 6 GO:0070169 positive regulation of biomineral tissue development 6/852 49/18722 0.0230634974569532 0.112697653107617 PTN/SMAD3/TGFB1/ISG15/BMPR2/FBN2 6 GO:0070849 response to epidermal growth factor 6/852 49/18722 0.0230634974569532 0.112697653107617 ERBB2/ZFP36L1/MAPK3/IQGAP1/ID1/ERRFI1 6 GO:0033674 positive regulation of kinase activity 31/852 467/18722 0.0232649191274941 0.113048878711347 IGF2/FLT1/FGFR1/SDC4/PRKAG2/ERBB2/TGFB1/GPRC5A/TGFB2/PTK2B/EPHB2/CSF1R/GCN1/EFNA1/INSR/SASH1/BMPR2/TIAM1/ADAM9/DAG1/PINK1/TXN/EGR1/MAGED1/DGKZ/PTK2/ERBB3/PRRC1/IQGAP1/ADAM17/ERP29 31 GO:0030178 negative regulation of Wnt signaling pathway 14/852 170/18722 0.0234646943492471 0.113048878711347 NOTUM/NOG/SFRP1/TCF7L2/WWTR1/APOE/TLE3/TPBG/EGR1/LRP1/JADE1/CSNK1A1/MDK/AMFR 14 GO:0002467 germinal center formation 3/852 14/18722 0.0234722984806989 0.113048878711347 TNFAIP3/PKN1/ADAM17 3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 3/852 14/18722 0.0234722984806989 0.113048878711347 GPRC5A/CBLB/ERRFI1 3 GO:0022038 corpus callosum development 3/852 14/18722 0.0234722984806989 0.113048878711347 PTPRS/EPHB2/C12orf57 3 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 3/852 14/18722 0.0234722984806989 0.113048878711347 PDGFRL/HIP1/LRP1 3 GO:0043558 regulation of translational initiation in response to stress 3/852 14/18722 0.0234722984806989 0.113048878711347 TMED2/PPP1R15B/DNAJC3 3 GO:0051547 regulation of keratinocyte migration 3/852 14/18722 0.0234722984806989 0.113048878711347 IQSEC1/MAPRE2/ADAM9 3 GO:0060576 intestinal epithelial cell development 3/852 14/18722 0.0234722984806989 0.113048878711347 IL6ST/KLF5/YIPF6 3 GO:0060841 venous blood vessel development 3/852 14/18722 0.0234722984806989 0.113048878711347 ENG/ACVRL1/BMPR2 3 GO:0061043 regulation of vascular wound healing 3/852 14/18722 0.0234722984806989 0.113048878711347 SERPINE1/XBP1/TNFAIP3 3 GO:0070141 response to UV-A 3/852 14/18722 0.0234722984806989 0.113048878711347 TIMP1/MMP2/OPN3 3 GO:0071481 cellular response to X-ray 3/852 14/18722 0.0234722984806989 0.113048878711347 SFRP1/GATA3/DNM2 3 GO:0072160 nephron tubule epithelial cell differentiation 3/852 14/18722 0.0234722984806989 0.113048878711347 GATA3/WWTR1/CTNNB1 3 GO:1901857 positive regulation of cellular respiration 3/852 14/18722 0.0234722984806989 0.113048878711347 PINK1/OPN3/IFNAR1 3 GO:0006650 glycerophospholipid metabolic process 22/852 306/18722 0.0235167403064437 0.113122657673843 APOC1/PLA2G7/LPCAT1/GDPD3/MFSD2A/SCARB1/CSF1R/PIGT/IPMK/FABP5/LDLR/DGKZ/PIK3CB/SLC44A2/CAPN2/SERINC3/INPPL1/PIK3R1/ACSL3/GPAA1/IMPA2/SERINC2 22 GO:0010827 regulation of glucose transmembrane transport 8/852 77/18722 0.0235550457465105 0.113122657673843 PRKAG2/ASPSCR1/INSR/PEA15/FABP5/OPN3/PIK3R1/RTN2 8 GO:0021675 nerve development 8/852 77/18722 0.0235550457465105 0.113122657673843 SERPINE2/CITED2/EPHB2/NAV2/CTNNB1/DAG1/ERBB3/SLC1A3 8 GO:0019318 hexose metabolic process 18/852 237/18722 0.0236524403564097 0.113374030775057 IGF2/POMC/GAA/B4GALT1/FAM3C/MAN2A1/INSR/ATF3/H6PD/FABP5/PPP1CB/FUCA2/INPPL1/TP53/DDB1/GLB1/GALE/ATF4 18 GO:0031334 positive regulation of protein-containing complex assembly 18/852 237/18722 0.0236524403564097 0.113374030775057 TGFB1/PTK2B/BAIAP2L1/CDC42EP5/ISG15/VASP/ABCA1/NCKAP1/PINK1/CDC42EP1/EVL/LGALS3/CTTN/TP53/GSN/MYO1C/RHOC/SH3GLB1 18 GO:0055076 transition metal ion homeostasis 12/852 138/18722 0.0236990990805115 0.113489596262811 EPAS1/SLC39A6/MT1X/SLC30A2/SLC39A8/PICALM/ANKRD9/XIAP/NDFIP1/SLC39A7/SRI/ATP6AP1 12 GO:0099601 regulation of neurotransmitter receptor activity 7/852 63/18722 0.0238900537962931 0.11429528589044 RASGRF2/PTK2B/EPHB2/IFNGR2/DLGAP4/DAPK1/PINK1 7 GO:0010927 cellular component assembly involved in morphogenesis 10/852 107/18722 0.0239153722064214 0.114307757184158 TPM1/ITGB1/KRT19/CD9/KRT8/PHLDB2/DAG1/GPC1/CSRP1/OBSL1 10 GO:0072163 mesonephric epithelium development 9/852 92/18722 0.024056773157168 0.114765629668272 NOG/SFRP1/GATA3/SDC4/SMAD3/SDC1/CTNNB1/LAMA5/MAGED1 9 GO:0072164 mesonephric tubule development 9/852 92/18722 0.024056773157168 0.114765629668272 NOG/SFRP1/GATA3/SDC4/SMAD3/SDC1/CTNNB1/LAMA5/MAGED1 9 GO:0007519 skeletal muscle tissue development 13/852 155/18722 0.0248422204246575 0.118278865124154 IGF2/FLNB/CITED2/TGFB1/ATF3/CTNNB1/RCAN1/CAV2/EGR1/GPC1/PPP3CA/KLF5/DDX17 13 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 20/852 273/18722 0.0250402944406782 0.118278865124154 PTPRF/ITGB1/IL1RAP/CLDN19/PLXNB2/FXYD5/PTPRS/TGFB2/PVR/FAT2/GPC4/ESAM/MYADM/PALLD/FAT1/DSG2/CD164/BSG/NPTN/OBSL1 20 GO:0031579 membrane raft organization 4/852 25/18722 0.0251383936952587 0.118278865124154 ABCA7/MYADM/CAV2/GSN 4 GO:0032469 endoplasmic reticulum calcium ion homeostasis 4/852 25/18722 0.0251383936952587 0.118278865124154 WFS1/HERPUD1/TMBIM6/TMCO1 4 GO:0060706 cell differentiation involved in embryonic placenta development 4/852 25/18722 0.0251383936952587 0.118278865124154 KRT19/GCM1/KRT8/GRHL2 4 GO:0099560 synaptic membrane adhesion 4/852 25/18722 0.0251383936952587 0.118278865124154 PTPRF/IL1RAP/PTPRS/GPC4 4 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 4/852 25/18722 0.0251383936952587 0.118278865124154 ADAMTS1/DOCK5/LRP1/IQGAP1 4 GO:1905564 positive regulation of vascular endothelial cell proliferation 4/852 25/18722 0.0251383936952587 0.118278865124154 IGF2/FGFR1/MDK/ADAM17 4 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 5/852 37/18722 0.0251524054413107 0.118278865124154 NOG/GATA3/CTNNB1/GPC1/NPTN 5 GO:0060416 response to growth hormone 5/852 37/18722 0.0251524054413107 0.118278865124154 GDF15/PXN/CSH1/PTK2/PIK3R1 5 GO:0090218 positive regulation of lipid kinase activity 5/852 37/18722 0.0251524054413107 0.118278865124154 FLT1/TGFB1/PTK2B/DGKZ/PTK2 5 GO:1902745 positive regulation of lamellipodium organization 5/852 37/18722 0.0251524054413107 0.118278865124154 NCKAP1/DNM2/ARHGEF7/PIK3R1/RREB1 5 GO:1905332 positive regulation of morphogenesis of an epithelium 5/852 37/18722 0.0251524054413107 0.118278865124154 NOG/GATA3/CTNNB1/MAGED1/MDK 5 GO:0046460 neutral lipid biosynthetic process 6/852 50/18722 0.0252341968373923 0.118278865124154 LPL/MFSD2A/SCARB1/LDLR/ACSL4/CTDNEP1 6 GO:0046463 acylglycerol biosynthetic process 6/852 50/18722 0.0252341968373923 0.118278865124154 LPL/MFSD2A/SCARB1/LDLR/ACSL4/CTDNEP1 6 GO:0060337 type I interferon signaling pathway 6/852 50/18722 0.0252341968373923 0.118278865124154 IFI27/ISG15/STAT2/JAK1/IFNAR1/UBE2K 6 GO:0110151 positive regulation of biomineralization 6/852 50/18722 0.0252341968373923 0.118278865124154 PTN/SMAD3/TGFB1/ISG15/BMPR2/FBN2 6 GO:0043297 apical junction assembly 8/852 78/18722 0.025239718089279 0.118278865124154 F11R/CLDN19/ESAM/GRHL2/MTDH/VCL/MYO1C/RHOC 8 GO:0070373 negative regulation of ERK1 and ERK2 cascade 8/852 78/18722 0.025239718089279 0.118278865124154 TIMP3/FBLN1/CAMK2N1/EPHB2/ATF3/DUSP4/EZR/ERRFI1 8 GO:0051591 response to cAMP 9/852 93/18722 0.0256008084944598 0.119859413165224 SPARC/PTK2B/SDC1/CARM1/ZFP36L1/FOSB/BSG/ITPR2/EZR 9 GO:0045995 regulation of embryonic development 7/852 64/18722 0.0258089519486699 0.120497639292816 PHLDB2/INSR/CTNNB1/DAG1/LAMA5/B4GALT5/CCSAP 7 GO:0055002 striated muscle cell development 7/852 64/18722 0.0258089519486699 0.120497639292816 TPM1/ITGB1/KRT19/KRT8/SDC1/CSRP1/OBSL1 7 GO:1903018 regulation of glycoprotein metabolic process 7/852 64/18722 0.0258089519486699 0.120497639292816 ITM2B/TCF7L2/ABCA7/TMEM59/CTNNB1/ITM2C/NCSTN 7 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 8/852 79/18722 0.0270067020532321 0.125972874359516 FN1/FLT1/FGFR1/TGFB2/INSR/PTK2/ERBB3/MYDGF 8 GO:0042593 glucose homeostasis 19/852 258/18722 0.0271337981398432 0.126448524109103 TCF7L2/HMGN3/PRCP/POMC/CAMK2N1/SOX4/ASPSCR1/ENDOG/XBP1/INSR/WFS1/TIAM1/FABP5/LRP1/PYGL/PPP3CA/PIK3R1/SLC16A1/SRI 19 GO:0032091 negative regulation of protein binding 9/852 94/18722 0.0272137180083067 0.126684051453467 PTPRF/NOG/ADAM15/ACTB/CTSZ/MAPK3/TMBIM6/SYMPK/ID1 9 GO:0002262 myeloid cell homeostasis 13/852 157/18722 0.0272346798475365 0.126684051453467 EPAS1/CITED2/GATA3/GATA2/INHA/PTBP3/ISG15/ZFP36L1/PIK3CB/RBFOX2/NCSTN/ADAM17/TGFBR3 13 GO:2001234 negative regulation of apoptotic signaling pathway 17/852 224/18722 0.0274930269523638 0.127767686658584 SERPINE1/NOG/TCF7L2/XBP1/HSPB1/TNFAIP3/WFS1/ARHGEF2/PEA15/CTNNB1/PINK1/TMEM14A/LGALS3/MIF/HERPUD1/CTTN/TMBIM6 17 GO:0014009 glial cell proliferation 6/852 51/18722 0.0275368060416499 0.127853085615889 ASCL2/PTN/TSPO/PTK2B/SOX4/GBA 6 GO:0007548 sex differentiation 20/852 276/18722 0.0277041719373382 0.12851161047062 FSTL3/TNFSF10/NRIP1/SFRP1/CITED2/GATA3/ADAMTS1/ADAM15/TGFB2/INHA/FLNA/PRDX4/MMP14/SDC1/CTNNB1/NCOA1/PLEKHA1/RHOBTB3/RDH10/TFAP2C 20 GO:0033692 cellular polysaccharide biosynthetic process 7/852 65/18722 0.027830461903215 0.128562159630391 IGF2/B3GNT7/PHKG1/INSR/PPP1CB/B4GALT5/EXT2 7 GO:0045453 bone resorption 7/852 65/18722 0.027830461903215 0.128562159630391 PTK2B/CSF1R/LTBP3/TNFAIP3/CTNNB1/UBASH3B/ATP6AP1 7 GO:0070936 protein K48-linked ubiquitination 7/852 65/18722 0.027830461903215 0.128562159630391 IFI27/TTC3/TNFAIP3/UBE2Q2/AMFR/UBE2K/UBE2A 7 GO:0006882 cellular zinc ion homeostasis 5/852 38/18722 0.027913843324773 0.128562159630391 SLC39A6/MT1X/SLC30A2/SLC39A8/SLC39A7 5 GO:0010719 negative regulation of epithelial to mesenchymal transition 5/852 38/18722 0.027913843324773 0.128562159630391 NOG/SFRP1/GATA3/TGFB2/EFNA1 5 GO:0030279 negative regulation of ossification 5/852 38/18722 0.027913843324773 0.128562159630391 SFRP1/PTK2B/CCR1/LTBP3/MDK 5 GO:0048713 regulation of oligodendrocyte differentiation 5/852 38/18722 0.027913843324773 0.128562159630391 PTN/CTNNB1/DAG1/MDK/RHEB 5 GO:0001659 temperature homeostasis 14/852 174/18722 0.027944963766272 0.128562159630391 DIO2/EPAS1/PLAC8/PTGES/PLCL2/MFAP2/EDNRB/TLE3/FABP5/EGR1/RHEB/ID1/ATF4/ADAM17 14 GO:0048639 positive regulation of developmental growth 14/852 174/18722 0.027944963766272 0.128562159630391 FN1/IGF2/SEMA5A/CRABP2/SLC23A2/INSR/BMPR2/PPIB/EIF4G2/LRP1/SEMA7A/EZR/TGFBR3/MACF1 14 GO:0033500 carbohydrate homeostasis 19/852 259/18722 0.0280864465593022 0.128630097563365 TCF7L2/HMGN3/PRCP/POMC/CAMK2N1/SOX4/ASPSCR1/ENDOG/XBP1/INSR/WFS1/TIAM1/FABP5/LRP1/PYGL/PPP3CA/PIK3R1/SLC16A1/SRI 19 GO:0002698 negative regulation of immune effector process 10/852 110/18722 0.0283165280998514 0.128630097563365 HLA-G/SERPING1/TGFB1/TGFB2/GRN/CD59/BST2/LGALS3/NDFIP1/TMBIM6 10 GO:0048259 regulation of receptor-mediated endocytosis 10/852 110/18722 0.0283165280998514 0.128630097563365 SERPINE1/APOC1/HIP1/CD63/ANKRD13A/INSR/DNM2/PICALM/PIK3CB/FMR1 10 GO:1905954 positive regulation of lipid localization 10/852 110/18722 0.0283165280998514 0.128630097563365 PTGES/LPL/ABCA7/APOE/SCARB1/ABCA1/LIPG/LRP1/RXRA/P2RX4 10 GO:0023035 CD40 signaling pathway 3/852 15/18722 0.0283686485784493 0.128630097563365 ITGA5/ITGB1/TNFAIP3 3 GO:0032486 Rap protein signal transduction 3/852 15/18722 0.0283686485784493 0.128630097563365 TIMP2/PLK2/SGSM3 3 GO:0032933 SREBP signaling pathway 3/852 15/18722 0.0283686485784493 0.128630097563365 TMED2/INSIG1/AMFR 3 GO:0034380 high-density lipoprotein particle assembly 3/852 15/18722 0.0283686485784493 0.128630097563365 ABCA7/APOE/ABCA1 3 GO:0048712 negative regulation of astrocyte differentiation 3/852 15/18722 0.0283686485784493 0.128630097563365 NOG/LDLR/MYCN 3 GO:0055091 phospholipid homeostasis 3/852 15/18722 0.0283686485784493 0.128630097563365 RCN3/ABCA1/LIPG 3 GO:0060253 negative regulation of glial cell proliferation 3/852 15/18722 0.0283686485784493 0.128630097563365 ASCL2/PTN/TSPO 3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 3/852 15/18722 0.0283686485784493 0.128630097563365 RNF139/SAR1A/YIPF5 3 GO:0070207 protein homotrimerization 3/852 15/18722 0.0283686485784493 0.128630097563365 HLA-G/SLC1A5/MIF 3 GO:0071474 cellular hyperosmotic response 3/852 15/18722 0.0283686485784493 0.128630097563365 ARHGEF2/EFHD1/ERRFI1 3 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 3/852 15/18722 0.0283686485784493 0.128630097563365 ABCA7/WFS1/PPP1R15B 3 GO:1904424 regulation of GTP binding 3/852 15/18722 0.0283686485784493 0.128630097563365 CLN5/CSNK1A1/ARHGEF7 3 GO:0050670 regulation of lymphocyte proliferation 17/852 225/18722 0.0285333414552789 0.128834329868971 IGF2/EBI3/IL6ST/HLA-G/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/PKN1/CBLB/CD320/CTNNB1/LGALS3/MIF/NDFIP1 17 GO:0006027 glycosaminoglycan catabolic process 4/852 26/18722 0.0286696700681994 0.128834329868971 TGFB1/NAGLU/GNS/GLB1 4 GO:0019883 antigen processing and presentation of endogenous antigen 4/852 26/18722 0.0286696700681994 0.128834329868971 HLA-G/TAP1/TAPBP/ERAP1 4 GO:0021680 cerebellar Purkinje cell layer development 4/852 26/18722 0.0286696700681994 0.128834329868971 HERC1/GBA/NAGLU/ARCN1 4 GO:0033598 mammary gland epithelial cell proliferation 4/852 26/18722 0.0286696700681994 0.128834329868971 GATA3/RTN4/ZNF703/RREB1 4 GO:0045672 positive regulation of osteoclast differentiation 4/852 26/18722 0.0286696700681994 0.128834329868971 CCR1/NOTCH2/KLF10/ATP6AP1 4 GO:0060037 pharyngeal system development 4/852 26/18722 0.0286696700681994 0.128834329868971 NOG/GATA3/TGFB2/BMPR2 4 GO:0097066 response to thyroid hormone 4/852 26/18722 0.0286696700681994 0.128834329868971 CTSL/CTSB/GBA/CTSH 4 GO:1904376 negative regulation of protein localization to cell periphery 4/852 26/18722 0.0286696700681994 0.128834329868971 TGFB1/TMEM59/PICALM/LYPLA1 4 GO:1904861 excitatory synapse assembly 4/852 26/18722 0.0286696700681994 0.128834329868971 IL1RAP/PLXNB2/PTPRS/NPTN 4 GO:2001235 positive regulation of apoptotic signaling pathway 11/852 126/18722 0.0287884470326383 0.129209685336712 TIMP3/TNFSF10/SFRP1/ATF3/PEA15/MAGED1/PDIA3/SERINC3/CTSH/TP53/ITM2C 11 GO:0007009 plasma membrane organization 12/852 142/18722 0.0288045434030978 0.129209685336712 CD9/ABCA7/TGFB2/BAIAP2L1/UGCG/DNM2/MYH9/CAV2/NDRG1/ARL8B/GSN/SH3GLB1 12 GO:0007422 peripheral nervous system development 8/852 80/18722 0.0288577045581772 0.12927823919567 CITED2/ERBB2/EDNRB/LAMB2/DAG1/NDRG1/ERBB3/GPC1 8 GO:0048709 oligodendrocyte differentiation 9/852 95/18722 0.028896884382104 0.12927823919567 PTN/CD9/ERBB2/CTNNB1/DAG1/B4GALT5/MDK/RHEB/NCSTN 9 GO:0050764 regulation of phagocytosis 9/852 95/18722 0.028896884382104 0.12927823919567 IL2RB/GATA2/ABCA7/SCARB1/CNN2/CALR/DNM2/LRP1/LMAN2 9 GO:0071241 cellular response to inorganic substance 17/852 226/18722 0.0296027397047453 0.132318462641193 AOC1/FSTL3/SYT8/TSPO/MT1X/ENDOG/CLIC4/CALR/DNM2/ADCY7/FOSB/MAPK3/IQGAP1/P2RX4/DDI2/NCSTN/FMR1 17 GO:0090288 negative regulation of cellular response to growth factor stimulus 10/852 111/18722 0.0299036823661157 0.133088401043764 FSTL3/HTRA1/FBN1/NOG/SFRP1/GATA3/CRIM1/PIK3CB/GPC1/EPN2 10 GO:0050766 positive regulation of phagocytosis 7/852 66/18722 0.0299566814392762 0.133088401043764 IL2RB/GATA2/ABCA7/CALR/DNM2/LRP1/LMAN2 7 GO:0021545 cranial nerve development 6/852 52/18722 0.029974024958641 0.133088401043764 CITED2/EPHB2/NAV2/CTNNB1/ERBB3/SLC1A3 6 GO:0030514 negative regulation of BMP signaling pathway 6/852 52/18722 0.029974024958641 0.133088401043764 FSTL3/HTRA1/FBN1/NOG/SFRP1/CRIM1 6 GO:0035196 production of miRNAs involved in gene silencing by miRNA 6/852 52/18722 0.029974024958641 0.133088401043764 SMAD3/TGFB1/NCOR2/MYCN/PPP3CA/TP53 6 GO:0048260 positive regulation of receptor-mediated endocytosis 6/852 52/18722 0.029974024958641 0.133088401043764 SERPINE1/HIP1/CD63/INSR/DNM2/FMR1 6 GO:0071357 cellular response to type I interferon 6/852 52/18722 0.029974024958641 0.133088401043764 IFI27/ISG15/STAT2/JAK1/IFNAR1/UBE2K 6 GO:0050890 cognition 21/852 296/18722 0.0299865382045754 0.133088401043764 ITGB1/PTN/ABCA7/APOE/MFSD2A/EPHB2/GM2A/INSR/PLK2/EIF4EBP2/PICALM/RCAN1/TPBG/LDLR/C12orf57/ARF4/NPTN/MDK/AMFR/NCSTN/MAGT1 21 GO:0030010 establishment of cell polarity 12/852 143/18722 0.0301964078608635 0.133901780408569 ITGB1/GATA3/PTK2B/FAT1/AMOTL2/MYH9/PTK2/GSN/GOLPH3/WEE1/MAP4/FRMD4A 12 GO:0035270 endocrine system development 11/852 127/18722 0.0302769534689907 0.13414076303647 FSTL3/NOG/CITED2/GATA3/TSPO/GATA2/SMAD3/SOX4/MAPK3/MDK/RHEB 11 GO:0001823 mesonephros development 9/852 96/18722 0.030651645222537 0.135681381182963 NOG/SFRP1/GATA3/SDC4/SMAD3/SDC1/CTNNB1/LAMA5/MAGED1 9 GO:0032944 regulation of mononuclear cell proliferation 17/852 227/18722 0.0307016597289834 0.135783350980644 IGF2/EBI3/IL6ST/HLA-G/SDC4/ERBB2/CD276/EFNB1/SLC7A1/EPHB2/PKN1/CBLB/CD320/CTNNB1/LGALS3/MIF/NDFIP1 17 GO:0002701 negative regulation of production of molecular mediator of immune response 5/852 39/18722 0.0308602447220647 0.136245273408905 TGFB1/TGFB2/BST2/NDFIP1/TMBIM6 5 GO:0090207 regulation of triglyceride metabolic process 5/852 39/18722 0.0308602447220647 0.136245273408905 APOE/MFSD2A/SCARB1/LDLR/CTDNEP1 5 GO:0048640 negative regulation of developmental growth 10/852 112/18722 0.0315527376904782 0.139180480978245 PLAC8/NOG/CITED2/GDF15/SEMA5A/PTPRS/SEMA4C/WWC3/RTN4/SEMA7A 10 GO:0072665 protein localization to vacuole 7/852 67/18722 0.0321895880522942 0.141865321074603 TNFAIP3/SCARB2/SH3BP4/RTN4/LMBRD1/LAMP2/SH3GLB1 7 GO:0014909 smooth muscle cell migration 9/852 97/18722 0.0324792905682661 0.142151557158913 TPM1/SERPINE1/IGFBP3/ADAMTS1/DOCK5/PARVA/LRP1/IQGAP1/MDK 9 GO:0009651 response to salt stress 4/852 27/18722 0.0324804869327935 0.142151557158913 PAPPA2/ZFP36L1/EFHD1/TP53 4 GO:0010561 negative regulation of glycoprotein biosynthetic process 4/852 27/18722 0.0324804869327935 0.142151557158913 ITM2B/ABCA7/TMEM59/ITM2C 4 GO:0033561 regulation of water loss via skin 4/852 27/18722 0.0324804869327935 0.142151557158913 UGCG/GBA/LSR/GRHL1 4 GO:0060142 regulation of syncytium formation by plasma membrane fusion 4/852 27/18722 0.0324804869327935 0.142151557158913 GDF15/GCM1/ADAM9/CAPN2 4 GO:0098901 regulation of cardiac muscle cell action potential 4/852 27/18722 0.0324804869327935 0.142151557158913 PKP2/DSG2/GJA5/JUP 4 GO:1903205 regulation of hydrogen peroxide-induced cell death 4/852 27/18722 0.0324804869327935 0.142151557158913 PYCR1/ENDOG/PINK1/TXN 4 GO:1903319 positive regulation of protein maturation 4/852 27/18722 0.0324804869327935 0.142151557158913 SOX4/MMP14/MYH9/GSN 4 GO:0034381 plasma lipoprotein particle clearance 6/852 53/18722 0.032548335183003 0.14220119008338 APOC1/APOE/SCARB1/LIPG/LDLR/CNPY2 6 GO:1903202 negative regulation of oxidative stress-induced cell death 6/852 53/18722 0.032548335183003 0.14220119008338 PYCR1/HSPB1/CTNNB1/PINK1/TXN/ATF4 6 GO:0071216 cellular response to biotic stimulus 18/852 246/18722 0.032627828696966 0.142424858483807 SERPINE1/TFPI/TSPO/TGFB1/SCARB1/EDNRB/XBP1/TNFAIP3/WFS1/SASH1/ABCA1/ADAM9/MTDH/MAPK3/CAPN2/PPP1R15B/TP53/TMCO1 18 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 19/852 264/18722 0.0332313238803063 0.14493349487832 IGF2/IL6ST/ITGA5/SFRP1/SH3BP5/CSH1/TGFB1/GPRC5A/PTK2B/CSF1R/EFNA1/ARHGEF2/CBLB/ERBB3/MIF/IQGAP1/TP53/ERRFI1/ADAM17 19 GO:0044344 cellular response to fibroblast growth factor stimulus 10/852 113/18722 0.0332647551778749 0.1449536907448 FGFR1/NOG/SFRP1/GATA3/GALNT3/CTNNB1/ZFP36L1/GPC1/NPTN/EXT2 10 GO:1903131 mononuclear cell differentiation 28/852 426/18722 0.0333312635117783 0.145117862677146 HLA-G/ITGB1/SFRP1/GATA3/PLCL2/ERBB2/PTK2B/INHA/SOX4/CTSL/XBP1/NOTCH2/CSF1R/MMP14/CTNNB1/HDAC5/GBA/MYH9/KLF6/ZFP36L1/EGR1/KDELR1/TP53/NDFIP1/MDK/PIK3R1/ADAM17/CLPTM1 28 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 3/852 16/18722 0.0337618798274858 0.145482483879911 ENG/NOG/TGFB2 3 GO:0005980 glycogen catabolic process 3/852 16/18722 0.0337618798274858 0.145482483879911 GAA/PPP1CB/PYGL 3 GO:0030033 microvillus assembly 3/852 16/18722 0.0337618798274858 0.145482483879911 FXYD5/KLF5/EZR 3 GO:0048385 regulation of retinoic acid receptor signaling pathway 3/852 16/18722 0.0337618798274858 0.145482483879911 CALR/DHRS3/CTBP2 3 GO:0060572 morphogenesis of an epithelial bud 3/852 16/18722 0.0337618798274858 0.145482483879911 NOG/CTNNB1/RDH10 3 GO:0071361 cellular response to ethanol 3/852 16/18722 0.0337618798274858 0.145482483879911 SLC23A2/ADCY7/ITPR2 3 GO:0071501 cellular response to sterol depletion 3/852 16/18722 0.0337618798274858 0.145482483879911 TMED2/INSIG1/AMFR 3 GO:0097284 hepatocyte apoptotic process 3/852 16/18722 0.0337618798274858 0.145482483879911 KRT8/GSN/KRT18 3 GO:0099633 protein localization to postsynaptic specialization membrane 3/852 16/18722 0.0337618798274858 0.145482483879911 GPC4/ADAM10/DAG1 3 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 3/852 16/18722 0.0337618798274858 0.145482483879911 GPC4/ADAM10/DAG1 3 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 3/852 16/18722 0.0337618798274858 0.145482483879911 GLRX/DNM2/ACTN4 3 GO:2001044 regulation of integrin-mediated signaling pathway 3/852 16/18722 0.0337618798274858 0.145482483879911 TIMP1/FLNA/CD63 3 GO:0034250 positive regulation of cellular amide metabolic process 13/852 162/18722 0.033948083326445 0.145736370192771 PLXNB2/ERBB2/PTK2B/SOX4/RPS27L/EFNA1/PICALM/PABPC1/EIF4G2/PINK1/MAPK3/FMR1/DNAJC3 13 GO:0014037 Schwann cell differentiation 5/852 40/18722 0.0339945357850812 0.145736370192771 LAMB2/DAG1/NDRG1/ERBB3/GPC1 5 GO:0044275 cellular carbohydrate catabolic process 5/852 40/18722 0.0339945357850812 0.145736370192771 GAA/SCARB2/PPP1CB/PYGL/TP53 5 GO:0045429 positive regulation of nitric oxide biosynthetic process 5/852 40/18722 0.0339945357850812 0.145736370192771 SMAD3/PTK2B/INSR/DNM2/P2RX4 5 GO:0055069 zinc ion homeostasis 5/852 40/18722 0.0339945357850812 0.145736370192771 SLC39A6/MT1X/SLC30A2/SLC39A8/SLC39A7 5 GO:0071526 semaphorin-plexin signaling pathway 5/852 40/18722 0.0339945357850812 0.145736370192771 SEMA5A/PLXNB2/FLNA/SEMA4C/SEMA7A 5 GO:0030522 intracellular receptor signaling pathway 19/852 265/18722 0.0343391232621255 0.147088346704917 SFRP1/CITED2/PRCP/NCOR2/TNFAIP3/PKN1/CALR/DHRS3/CARM1/CTBP2/NCOA1/FABP5/SLC15A3/ACTN4/RBFOX2/RXRA/XIAP/SEC14L1/DDX17 19 GO:0010950 positive regulation of endopeptidase activity 14/852 179/18722 0.0343932381481344 0.147194870407789 TNFSF10/EGLN3/SMAD3/HIP1/RPS27L/EFNA1/DAP/PICALM/DAPK1/TBC1D10A/NLRP2/CTSH/NCSTN/GSN 14 GO:1904888 cranial skeletal system development 7/852 68/18722 0.0345310343081795 0.147573126444843 SMAD3/TGFB2/MMP14/INSIG1/GRHL2/CTNNB1/RDH10 7 GO:0022408 negative regulation of cell-cell adhesion 15/852 196/18722 0.0345402628555582 0.147573126444843 SERPINE2/HLA-G/CD9/SDC4/ERBB2/FXYD5/TGFB1/MYADM/CBLB/UBASH3B/PTK2/LGALS3/ZNF703/NDFIP1/MDK 15 GO:0042542 response to hydrogen peroxide 12/852 146/18722 0.0346619838578639 0.147967569768133 IL18BP/PYCR1/PTK2B/ENDOG/TNFAIP3/SDC1/ADAM9/PINK1/PLEKHA1/TXN/CAPN2/PPP1R15B 12 GO:0044262 cellular carbohydrate metabolic process 20/852 283/18722 0.0347477782550424 0.148208108438668 IGF2/IL6ST/PRKAG2/POMC/B3GNT7/PHKG1/PTK2B/GAA/B4GALT1/FAM3C/INSR/SCARB2/PPP1CB/PYGL/B4GALT5/TP53/DDB1/GLB1/EXT2/IMPA2 20 GO:0002244 hematopoietic progenitor cell differentiation 10/852 114/18722 0.0350407609261994 0.149204864417565 FSTL3/FLT1/SFRP1/CITED2/GATA3/TGFB1/TMEM91/SOX4/CSF1R/TP53 10 GO:0007041 lysosomal transport 10/852 114/18722 0.0350407609261994 0.149204864417565 PSAP/GRN/SCARB2/LAMP1/PINK1/LRP1/IGF2R/ARL8B/AP1G1/LAMP2 10 GO:1901214 regulation of neuron death 22/852 319/18722 0.0351508653695839 0.14951441994611 EGLN3/GATA3/ITGA1/TGFB2/SLC23A2/PTK2B/APOE/GRN/WFS1/CTNNB1/GBA/PICALM/PINK1/CTSZ/EGR1/ERBB3/LRP1/CAPN2/TP53/MDK/ATF4/TMEM259 22 GO:0031050 dsRNA processing 6/852 54/18722 0.0352619941339226 0.14951441994611 SMAD3/TGFB1/NCOR2/MYCN/PPP3CA/TP53 6 GO:0060350 endochondral bone morphogenesis 6/852 54/18722 0.0352619941339226 0.14951441994611 COL27A1/SERPINH1/MMP14/BMPR2/INPPL1/EXT2 6 GO:0070918 production of small RNA involved in gene silencing by RNA 6/852 54/18722 0.0352619941339226 0.14951441994611 SMAD3/TGFB1/NCOR2/MYCN/PPP3CA/TP53 6 GO:0086002 cardiac muscle cell action potential involved in contraction 6/852 54/18722 0.0352619941339226 0.14951441994611 KCNJ2/FLNA/PKP2/DSG2/GJA5/JUP 6 GO:0044242 cellular lipid catabolic process 16/852 214/18722 0.0357342419673642 0.151389259109212 HEXB/APOC1/PLA2G7/LPL/GDPD3/MFSD2A/SCARB1/GM2A/GBA/ACOX1/MGLL/LIPG/LDLR/LRP1/HEXA/NEU1 16 GO:0007033 vacuole organization 14/852 180/18722 0.0358019883912349 0.151548702752805 HEXB/GRN/GAA/MAN2A1/ABCA1/SCARB2/WIPI1/GBA/PINK1/CLN5/NAGLU/ARL8B/SEC22B/SH3GLB1 14 GO:0060041 retina development in camera-type eye 12/852 147/18722 0.0362496995866299 0.153186178018059 COL4A1/PTN/ACVRL1/LPCAT1/TGFB2/MFSD2A/LAMB2/MAN2A1/CLIC4/BMPR2/NAGLU/OBSL1 12 GO:1902652 secondary alcohol metabolic process 12/852 147/18722 0.0362496995866299 0.153186178018059 APOE/SCARB1/LIMA1/INSIG1/CYP11A1/ABCA1/NPC2/GBA/LDLR/RXRA/HDLBP/CYB5R3 12 GO:0060291 long-term synaptic potentiation 9/852 99/18722 0.0363581428653927 0.153266337113582 SERPINE2/PTN/RASGRF2/PTK2B/APOE/EPHB2/PLK2/NPTN/NCSTN 9 GO:0006829 zinc ion transport 4/852 28/18722 0.0365731911133344 0.153266337113582 SLC39A6/SLC30A2/SLC39A8/SLC39A7 4 GO:0006972 hyperosmotic response 4/852 28/18722 0.0365731911133344 0.153266337113582 PKN1/ARHGEF2/EFHD1/ERRFI1 4 GO:0032801 receptor catabolic process 4/852 28/18722 0.0365731911133344 0.153266337113582 TGFB1/APOE/FURIN/SH3GLB1 4 GO:0042983 amyloid precursor protein biosynthetic process 4/852 28/18722 0.0365731911133344 0.153266337113582 ITM2B/ABCA7/ITM2C/NCSTN 4 GO:0042984 regulation of amyloid precursor protein biosynthetic process 4/852 28/18722 0.0365731911133344 0.153266337113582 ITM2B/ABCA7/ITM2C/NCSTN 4 GO:0045686 negative regulation of glial cell differentiation 4/852 28/18722 0.0365731911133344 0.153266337113582 NOG/CTNNB1/LDLR/MYCN 4 GO:0051894 positive regulation of focal adhesion assembly 4/852 28/18722 0.0365731911133344 0.153266337113582 SFRP1/SDC4/SMAD3/IQGAP1 4 GO:0060325 face morphogenesis 4/852 28/18722 0.0365731911133344 0.153266337113582 NOG/MMP2/CRISPLD2/PLEKHA1 4 GO:0061082 myeloid leukocyte cytokine production 4/852 28/18722 0.0365731911133344 0.153266337113582 HLA-G/TGFB1/TGFB2/SEMA7A 4 GO:0046683 response to organophosphorus 11/852 131/18722 0.0367813190162512 0.154010298343421 SPARC/PTK2B/HSP90B1/SDC1/CARM1/ZFP36L1/FOSB/BSG/ITPR2/P2RX4/EZR 11 GO:0050680 negative regulation of epithelial cell proliferation 13/852 164/18722 0.0369406714499387 0.154548960438522 FLT1/SPARC/SFRP1/PTN/GATA3/ACVRL1/TGFB1/TGFB2/APOE/CDKN1C/CAV2/MAGED1/TGFBR3 13 GO:0032370 positive regulation of lipid transport 8/852 84/18722 0.0371335020196114 0.154969250136571 PTGES/ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA/P2RX4 8 GO:0045445 myoblast differentiation 8/852 84/18722 0.0371335020196114 0.154969250136571 IGFBP3/EPAS1/TCF7L2/TGFB1/ID3/SDC1/ZFP36L1/DDX17 8 GO:0097061 dendritic spine organization 8/852 84/18722 0.0371335020196114 0.154969250136571 PDLIM5/APOE/EPHB2/EFNA1/INSR/ADAM10/TIAM1/CTTN 8 GO:1905952 regulation of lipid localization 14/852 181/18722 0.0372517775976435 0.155101144743482 PTGES/TSPO/POMC/APOC1/LPL/ABCA7/APOE/SCARB1/ABCA1/LIPG/LRP1/RXRA/P2RX4/FURIN 14 GO:0042307 positive regulation of protein import into nucleus 5/852 41/18722 0.0373191905989184 0.155101144743482 SMAD3/TGFB1/FLNA/JUP/PIK3R1 5 GO:0048286 lung alveolus development 5/852 41/18722 0.0373191905989184 0.155101144743482 MAN2A1/LTBP3/BMPR2/MAN1A2/ERRFI1 5 GO:0071634 regulation of transforming growth factor beta production 5/852 41/18722 0.0373191905989184 0.155101144743482 FN1/LTBP1/SMAD3/TGFB2/FURIN 5 GO:1904407 positive regulation of nitric oxide metabolic process 5/852 41/18722 0.0373191905989184 0.155101144743482 SMAD3/PTK2B/INSR/DNM2/P2RX4 5 GO:0044272 sulfur compound biosynthetic process 12/852 148/18722 0.0378882263668138 0.157336174343378 CHPF/B3GNT7/UGDH/DSEL/TECR/CHPF2/ACSL4/ST3GAL6/AMD1/DSE/EXT2/ACSL3 12 GO:0048016 inositol phosphate-mediated signaling 6/852 55/18722 0.0381170301559026 0.158155822567731 FHL2/RCAN1/PPP3CA/ITPR2/CAMTA1/NFAT5 6 GO:0045123 cellular extravasation 7/852 70/18722 0.0395463065222565 0.161830846043129 IL1R1/ITGB1/F11R/JAM2/ITGA1/MDK/GOLPH3 7 GO:0060415 muscle tissue morphogenesis 7/852 70/18722 0.0395463065222565 0.161830846043129 TPM1/ENG/NOG/TGFB1/TGFB2/PKP2/TGFBR3 7 GO:0016525 negative regulation of angiogenesis 12/852 149/18722 0.0395782623641256 0.161830846043129 SERPINE1/SPARC/HSPG2/HLA-G/COL4A2/PTN/ADAMTS1/TGFB2/PLK2/CTNNB1/PIK3CB/EPN2 12 GO:0032368 regulation of lipid transport 12/852 149/18722 0.0395782623641256 0.161830846043129 PTGES/TSPO/POMC/APOC1/ABCA7/APOE/ABCA1/LIPG/LRP1/RXRA/P2RX4/FURIN 12 GO:0003184 pulmonary valve morphogenesis 3/852 17/18722 0.0396458241945516 0.161830846043129 TGFB2/NOTCH2/GJA5 3 GO:0009251 glucan catabolic process 3/852 17/18722 0.0396458241945516 0.161830846043129 GAA/PPP1CB/PYGL 3 GO:0010566 regulation of ketone biosynthetic process 3/852 17/18722 0.0396458241945516 0.161830846043129 ADM/H6PD/EGR1 3 GO:0010612 regulation of cardiac muscle adaptation 3/852 17/18722 0.0396458241945516 0.161830846043129 SMAD3/PPP3CA/ERRFI1 3 GO:0010715 regulation of extracellular matrix disassembly 3/852 17/18722 0.0396458241945516 0.161830846043129 TGFB1/LRP1/DPP4 3 GO:0030903 notochord development 3/852 17/18722 0.0396458241945516 0.161830846043129 NOG/ID3/EFNA1 3 GO:0036035 osteoclast development 3/852 17/18722 0.0396458241945516 0.161830846043129 FBN1/NOTCH2/ATP6AP1 3 GO:0038065 collagen-activated signaling pathway 3/852 17/18722 0.0396458241945516 0.161830846043129 COL4A2/COL4A1/UBASH3B 3 GO:0043117 positive regulation of vascular permeability 3/852 17/18722 0.0396458241945516 0.161830846043129 TGFB1/APOE/TJP2 3 GO:0055119 relaxation of cardiac muscle 3/852 17/18722 0.0396458241945516 0.161830846043129 KCNJ2/P2RX4/GSN 3 GO:0070206 protein trimerization 3/852 17/18722 0.0396458241945516 0.161830846043129 HLA-G/SLC1A5/MIF 3 GO:0070593 dendrite self-avoidance 3/852 17/18722 0.0396458241945516 0.161830846043129 PALLD/BSG/NPTN 3 GO:0097067 cellular response to thyroid hormone stimulus 3/852 17/18722 0.0396458241945516 0.161830846043129 CTSL/CTSB/CTSH 3 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 3/852 17/18722 0.0396458241945516 0.161830846043129 SMAD3/PPP3CA/ERRFI1 3 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 3/852 17/18722 0.0396458241945516 0.161830846043129 GATA3/WWTR1/CTNNB1 3 GO:2000811 negative regulation of anoikis 3/852 17/18722 0.0396458241945516 0.161830846043129 ITGA5/ITGB1/PTK2 3 GO:1902904 negative regulation of supramolecular fiber organization 13/852 166/18722 0.0401165343447243 0.163619544049431 F11R/TMSB10/CAPG/APOE/MYADM/LIMA1/PHLDB2/ARHGEF2/LDLR/SSH2/ARHGEF7/PIK3R1/GSN 13 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 11/852 133/18722 0.0403756494749606 0.164543031423058 PTK2B/PLK2/GBA/ANKIB1/PTK2/HERPUD1/RNF144B/RNF139/CSNK1A1/FMR1/TMEM259 11 GO:0034599 cellular response to oxidative stress 20/852 288/18722 0.0405370685109503 0.164933763795968 TPM1/EPAS1/IL18BP/MMP2/P4HB/PXN/PYCR1/ENDOG/HSPB1/SOD3/TNFAIP3/GPX8/CTNNB1/DAPK1/PINK1/PLEKHA1/TXN/MAPK3/TP53/ATF4 20 GO:0097193 intrinsic apoptotic signaling pathway 20/852 288/18722 0.0405370685109503 0.164933763795968 P4HB/XBP1/RPS27L/HSPB1/WFS1/ARHGEF2/SGPP1/PINK1/MIF/HERPUD1/SERINC3/DNAJC10/TP53/ERO1A/TMBIM6/SHISA5/PIK3R1/UBE2K/ATF4/ERP29 20 GO:0021795 cerebral cortex cell migration 5/852 42/18722 0.0408362308232669 0.165009413356754 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0045214 sarcomere organization 5/852 42/18722 0.0408362308232669 0.165009413356754 TPM1/ITGB1/KRT19/KRT8/CSRP1 5 GO:0048489 synaptic vesicle transport 5/852 42/18722 0.0408362308232669 0.165009413356754 AP3S1/CTNNB1/DNM2/PICALM/PINK1 5 GO:0055090 acylglycerol homeostasis 5/852 42/18722 0.0408362308232669 0.165009413356754 LPL/ANGPTL4/APOE/SCARB1/XBP1 5 GO:0060999 positive regulation of dendritic spine development 5/852 42/18722 0.0408362308232669 0.165009413356754 APOE/TIAM1/MAPK6/EIF4G2/FMR1 5 GO:0070328 triglyceride homeostasis 5/852 42/18722 0.0408362308232669 0.165009413356754 LPL/ANGPTL4/APOE/SCARB1/XBP1 5 GO:0090317 negative regulation of intracellular protein transport 5/852 42/18722 0.0408362308232669 0.165009413356754 OS9/INSIG1/LMAN1/TXN/PKIG 5 GO:0032366 intracellular sterol transport 4/852 29/18722 0.0409490874791547 0.165009413356754 ABCA1/NPC2/LDLR/ARL8B 4 GO:0032367 intracellular cholesterol transport 4/852 29/18722 0.0409490874791547 0.165009413356754 ABCA1/NPC2/LDLR/ARL8B 4 GO:0034067 protein localization to Golgi apparatus 4/852 29/18722 0.0409490874791547 0.165009413356754 TMED10/GOLPH3/ARL5B/OBSL1 4 GO:1902430 negative regulation of amyloid-beta formation 4/852 29/18722 0.0409490874791547 0.165009413356754 ABCA7/APOE/RTN4/RTN2 4 GO:1903902 positive regulation of viral life cycle 4/852 29/18722 0.0409490874791547 0.165009413356754 P4HB/CAV2/DDB1/FMR1 4 GO:0034612 response to tumor necrosis factor 18/852 253/18722 0.0411874430252766 0.165837120596974 SFRP1/GATA3/IL18BP/PTK2B/KRT8/ENDOG/TNFAIP3/ARHGEF2/ADAM10/ADAM9/GBA/ZFP36L1/MAPK3/ACTN4/TP53/UBE2K/KRT18/ADAM17 18 GO:0006413 translational initiation 10/852 118/18722 0.0428038715411615 0.172070196059637 HSPB1/TMED2/EIF4EBP1/EIF4EBP2/EIF4G2/PPP1R15B/FMR1/ATF4/EIF4B/DNAJC3 10 GO:0034219 carbohydrate transmembrane transport 10/852 118/18722 0.0428038715411615 0.172070196059637 PRKAG2/SLC23A2/ASPSCR1/INSR/PEA15/FABP5/SLC17A5/OPN3/PIK3R1/RTN2 10 GO:0055067 monovalent inorganic cation homeostasis 12/852 151/18722 0.0431155428521331 0.173046672388186 SLC4A7/SLC12A8/KCNJ2/EDNRB/GRN/CLIC4/ATP6V0E1/CLN5/MAPK3/SLC1A3/EXT2/ATP6AP1 12 GO:2000181 negative regulation of blood vessel morphogenesis 12/852 151/18722 0.0431155428521331 0.173046672388186 SERPINE1/SPARC/HSPG2/HLA-G/COL4A2/PTN/ADAMTS1/TGFB2/PLK2/CTNNB1/PIK3CB/EPN2 12 GO:0007611 learning or memory 18/852 255/18722 0.0439069018342703 0.176082419866042 ITGB1/PTN/ABCA7/APOE/EPHB2/GM2A/INSR/PLK2/EIF4EBP2/PICALM/RCAN1/TPBG/LDLR/ARF4/NPTN/MDK/AMFR/NCSTN 18 GO:0050891 multicellular organismal water homeostasis 6/852 57/18722 0.0442581787160078 0.17693391934162 UGCG/WFS1/GBA/LSR/EXT2/GRHL1 6 GO:0061005 cell differentiation involved in kidney development 6/852 57/18722 0.0442581787160078 0.17693391934162 GATA3/WWTR1/NOTCH2/LAMB2/CTNNB1/IQGAP1 6 GO:0061756 leukocyte adhesion to vascular endothelial cell 6/852 57/18722 0.0442581787160078 0.17693391934162 ITGB1/JAM2/SLC39A8/MDK/GOLPH3/NFAT5 6 GO:0019915 lipid storage 8/852 87/18722 0.0442950006696685 0.17693391934162 HEXB/NRIP1/LPL/APOE/SCARB1/GM2A/ABCA1/GBA 8 GO:2000177 regulation of neural precursor cell proliferation 8/852 87/18722 0.0442950006696685 0.17693391934162 PTN/GATA2/FLNA/CTNNB1/CTSZ/TP53/MDK/SPINT1 8 GO:0030517 negative regulation of axon extension 5/852 43/18722 0.0445472275119204 0.177378319673652 SEMA5A/PTPRS/SEMA4C/RTN4/SEMA7A 5 GO:0032365 intracellular lipid transport 5/852 43/18722 0.0445472275119204 0.177378319673652 ABCA1/NPC2/SGPP1/LDLR/ARL8B 5 GO:0033173 calcineurin-NFAT signaling cascade 5/852 43/18722 0.0445472275119204 0.177378319673652 FHL2/RCAN1/PPP3CA/CAMTA1/NFAT5 5 GO:1904591 positive regulation of protein import 5/852 43/18722 0.0445472275119204 0.177378319673652 SMAD3/TGFB1/FLNA/JUP/PIK3R1 5 GO:1901343 negative regulation of vasculature development 12/852 152/18722 0.0449640692218239 0.178639401952392 SERPINE1/SPARC/HSPG2/HLA-G/COL4A2/PTN/ADAMTS1/TGFB2/PLK2/CTNNB1/PIK3CB/EPN2 12 GO:0030330 DNA damage response, signal transduction by p53 class mediator 7/852 72/18722 0.0450146708042499 0.178639401952392 SOX4/RPS27L/PLK2/NDRG1/MIF/MYO6/TP53 7 GO:0042246 tissue regeneration 7/852 72/18722 0.0450146708042499 0.178639401952392 PTN/CD9/ADAM15/DAG1/PPP3CA/KLF5/MDK 7 GO:0030004 cellular monovalent inorganic cation homeostasis 9/852 103/18722 0.0450414069297805 0.178639401952392 SLC4A7/KCNJ2/GRN/CLIC4/ATP6V0E1/CLN5/MAPK3/SLC1A3/ATP6AP1 9 GO:0050773 regulation of dendrite development 9/852 103/18722 0.0450414069297805 0.178639401952392 PTN/MFSD2A/TIAM1/CARM1/IQGAP1/PPP3CA/ID1/CUX1/OBSL1 9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 14/852 186/18722 0.0451350955158094 0.1788700281347 TNFSF10/FLNA/PLK2/MTDH/CTNNB1/PINK1/BST2/GOLT1B/SLC44A2/NDFIP2/S100A13/NDFIP1/SHISA5/RHOC 14 GO:0021543 pallium development 13/852 169/18722 0.0452343652681195 0.178961732664576 HSD3B1/PTPRS/MFSD2A/FLNA/SRGAP2C/SRGAP2/CTNNB1/RTN4/NCOA1/LRP1/SUN2/MDK/TACC1 13 GO:0031214 biomineral tissue development 13/852 169/18722 0.0452343652681195 0.178961732664576 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2/KLF10/ATF4 13 GO:0007176 regulation of epidermal growth factor-activated receptor activity 4/852 30/18722 0.0456084792070204 0.178961732664576 GPRC5A/CBLB/ERRFI1/ADAM17 4 GO:0008209 androgen metabolic process 4/852 30/18722 0.0456084792070204 0.178961732664576 ADM/HSD3B1/SCARB1/PLEKHA1 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/852 30/18722 0.0456084792070204 0.178961732664576 SOX4/RPS27L/PLK2/TP53 4 GO:0060674 placenta blood vessel development 4/852 30/18722 0.0456084792070204 0.178961732664576 PLCD3/NOTCH2/TMED2/SPINT1 4 GO:0061311 cell surface receptor signaling pathway involved in heart development 4/852 30/18722 0.0456084792070204 0.178961732664576 NOG/TGFB1/NOTCH2/CTNNB1 4 GO:0070168 negative regulation of biomineral tissue development 4/852 30/18722 0.0456084792070204 0.178961732664576 TGFB1/PTK2B/CCR1/LTBP3 4 GO:0070498 interleukin-1-mediated signaling pathway 4/852 30/18722 0.0456084792070204 0.178961732664576 IL1R1/IL1R2/EGR1/MAPK3 4 GO:0140058 neuron projection arborization 4/852 30/18722 0.0456084792070204 0.178961732664576 PTN/MFSD2A/TPBG/MACF1 4 GO:1903019 negative regulation of glycoprotein metabolic process 4/852 30/18722 0.0456084792070204 0.178961732664576 ITM2B/ABCA7/TMEM59/ITM2C 4 GO:2000637 positive regulation of gene silencing by miRNA 4/852 30/18722 0.0456084792070204 0.178961732664576 TGFB1/MYCN/TP53/FMR1 4 GO:0006595 polyamine metabolic process 3/852 18/18722 0.0460116197234176 0.178961732664576 AOC1/SAT1/AMD1 3 GO:0006991 response to sterol depletion 3/852 18/18722 0.0460116197234176 0.178961732664576 TMED2/INSIG1/AMFR 3 GO:0015732 prostaglandin transport 3/852 18/18722 0.0460116197234176 0.178961732664576 PTGES/SLCO2A1/P2RX4 3 GO:0030728 ovulation 3/852 18/18722 0.0460116197234176 0.178961732664576 HPGD/NRIP1/ADAMTS1 3 GO:0044247 cellular polysaccharide catabolic process 3/852 18/18722 0.0460116197234176 0.178961732664576 GAA/PPP1CB/PYGL 3 GO:0046851 negative regulation of bone remodeling 3/852 18/18722 0.0460116197234176 0.178961732664576 SFRP1/TNFAIP3/UBASH3B 3 GO:0048268 clathrin coat assembly 3/852 18/18722 0.0460116197234176 0.178961732664576 HIP1/CLTB/PICALM 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/852 18/18722 0.0460116197234176 0.178961732664576 TGFB1/BMPR2/RBPMS 3 GO:0071071 regulation of phospholipid biosynthetic process 3/852 18/18722 0.0460116197234176 0.178961732664576 LPCAT1/CAPN2/ACSL3 3 GO:0071786 endoplasmic reticulum tubular network organization 3/852 18/18722 0.0460116197234176 0.178961732664576 ATL3/RTN4/REEP3 3 GO:0072079 nephron tubule formation 3/852 18/18722 0.0460116197234176 0.178961732664576 NOG/GATA3/CTNNB1 3 GO:0097709 connective tissue replacement 3/852 18/18722 0.0460116197234176 0.178961732664576 TIMP1/TGFB1/PPP3CA 3 GO:0045727 positive regulation of translation 11/852 136/18722 0.046212431830849 0.179603991818272 PLXNB2/ERBB2/PTK2B/SOX4/RPS27L/PABPC1/EIF4G2/PINK1/MAPK3/FMR1/DNAJC3 11 GO:0071383 cellular response to steroid hormone stimulus 15/852 204/18722 0.0463716169067894 0.180083601768419 TFPI/SFRP1/SMYD3/FBXO32/NCOR2/PKN1/CALR/CARM1/ZFP36L1/PAQR7/PGRMC2/RBFOX2/RXRA/ERRFI1/DDX17 15 GO:0030218 erythrocyte differentiation 10/852 120/18722 0.0470931923709455 0.182604034825092 EPAS1/CITED2/GATA3/GATA2/INHA/PTBP3/ISG15/ZFP36L1/RBFOX2/TGFBR3 10 GO:0071774 response to fibroblast growth factor 10/852 120/18722 0.0470931923709455 0.182604034825092 FGFR1/NOG/SFRP1/GATA3/GALNT3/CTNNB1/ZFP36L1/GPC1/NPTN/EXT2 10 GO:0002763 positive regulation of myeloid leukocyte differentiation 6/852 58/18722 0.0475471717580169 0.183656880627858 TGFB1/CCR1/NOTCH2/ZFP36L1/KLF10/ATP6AP1 6 GO:0032387 negative regulation of intracellular transport 6/852 58/18722 0.0475471717580169 0.183656880627858 OS9/INSIG1/LMAN1/TXN/PKIG/ARHGAP1 6 GO:0034340 response to type I interferon 6/852 58/18722 0.0475471717580169 0.183656880627858 IFI27/ISG15/STAT2/JAK1/IFNAR1/UBE2K 6 GO:0035904 aorta development 6/852 58/18722 0.0475471717580169 0.183656880627858 ENG/FKBP10/ACVRL1/TGFB2/SOX4/LRP1 6 GO:0086065 cell communication involved in cardiac conduction 6/852 58/18722 0.0475471717580169 0.183656880627858 FLNA/PKP2/DSG2/GJA5/JUP/SRI 6 GO:0032732 positive regulation of interleukin-1 production 7/852 73/18722 0.0479219606817042 0.184962598244645 LPL/SMAD3/HSPB1/TMED10/EGR1/NLRP2/S100A13 7 GO:0031348 negative regulation of defense response 18/852 258/18722 0.0482245660258019 0.185915207682716 HTRA1/HLA-G/SERPING1/GATA3/SMAD3/APOE/GRN/ISG15/TNFAIP3/PLK2/GBA/STAT2/LDLR/FURIN/NDFIP1/SEC14L1/MDK/PCBP2 18 GO:0034754 cellular hormone metabolic process 11/852 137/18722 0.0482795899942995 0.185915207682716 ADM/HSD3B1/TTR/TSPO/CRABP2/SCARB1/CYP11A1/DHRS3/PLEKHA1/EGR1/RDH10 11 GO:0060048 cardiac muscle contraction 11/852 137/18722 0.0482795899942995 0.185915207682716 TPM1/KCNJ2/FLNA/GAA/PKP2/DSG2/GJA5/P2RX4/JUP/GSN/SRI 11 GO:0007528 neuromuscular junction development 5/852 44/18722 0.0484533049483107 0.186156857866296 COL4A1/PTN/ERBB2/PPFIBP2/LAMB2 5 GO:0032881 regulation of polysaccharide metabolic process 5/852 44/18722 0.0484533049483107 0.186156857866296 IGF2/POMC/TGFB1/INSR/PPP1CB 5 GO:0045124 regulation of bone resorption 5/852 44/18722 0.0484533049483107 0.186156857866296 CSF1R/LTBP3/TNFAIP3/UBASH3B/ATP6AP1 5 GO:0048839 inner ear development 14/852 188/18722 0.0485938863910432 0.186554561560733 SPARC/GATA3/SLC4A7/SDC4/GATA2/TGFB2/EPHB2/INSIG1/ADAM10/LRP10/NAGLU/MYCL/MYO6/MYCN 14 GO:0016052 carbohydrate catabolic process 12/852 154/18722 0.0488239144711118 0.18725796235659 HEXB/PRKAG2/GAA/GM2A/INSR/SCARB2/PPP1CB/PYGL/TP53/GLB1/GALE/NEU1 12 GO:0042129 regulation of T cell proliferation 13/852 171/18722 0.0488887269097078 0.18725796235659 IGF2/EBI3/IL6ST/HLA-G/SDC4/ERBB2/CD276/EFNB1/SLC7A1/CBLB/CTNNB1/LGALS3/NDFIP1 13 GO:0110148 biomineralization 13/852 171/18722 0.0488887269097078 0.18725796235659 NOTUM/PTN/SMAD3/TGFB1/PTK2B/SGMS2/CCR1/ISG15/LTBP3/BMPR2/FBN2/KLF10/ATF4 13 GO:0042177 negative regulation of protein catabolic process 10/852 121/18722 0.0493425719781722 0.188852596780335 SERPINE2/TIMP3/TIMP2/TIMP1/SMAD3/FLNA/EFNA1/CTSA/FURIN/PTPN3 10 GO:0014910 regulation of smooth muscle cell migration 8/852 89/18722 0.0495417811510852 0.189327095317701 TPM1/SERPINE1/IGFBP3/ADAMTS1/DOCK5/LRP1/IQGAP1/MDK 8 GO:1900407 regulation of cellular response to oxidative stress 8/852 89/18722 0.0495417811510852 0.189327095317701 P4HB/PYCR1/ENDOG/HSPB1/CTNNB1/PINK1/TXN/ATF4 8 GO:0032273 positive regulation of protein polymerization 11/852 138/18722 0.0504086088923441 0.191871592120013 PTK2B/BAIAP2L1/CDC42EP5/VASP/NCKAP1/PINK1/CDC42EP1/EVL/CTTN/GSN/MYO1C 11 GO:0002717 positive regulation of natural killer cell mediated immunity 4/852 31/18722 0.0505507115341024 0.191871592120013 HLA-G/PVR/LAMP1/AP1G1 4 GO:0036474 cell death in response to hydrogen peroxide 4/852 31/18722 0.0505507115341024 0.191871592120013 PYCR1/ENDOG/PINK1/TXN 4 GO:0036475 neuron death in response to oxidative stress 4/852 31/18722 0.0505507115341024 0.191871592120013 ENDOG/CTNNB1/PINK1/ATF4 4 GO:0044819 mitotic G1/S transition checkpoint signaling 4/852 31/18722 0.0505507115341024 0.191871592120013 SOX4/RPS27L/PLK2/TP53 4 GO:0060148 positive regulation of posttranscriptional gene silencing 4/852 31/18722 0.0505507115341024 0.191871592120013 TGFB1/MYCN/TP53/FMR1 4 GO:0061099 negative regulation of protein tyrosine kinase activity 4/852 31/18722 0.0505507115341024 0.191871592120013 SH3BP5/GPRC5A/CBLB/ERRFI1 4 GO:0110150 negative regulation of biomineralization 4/852 31/18722 0.0505507115341024 0.191871592120013 TGFB1/PTK2B/CCR1/LTBP3 4 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/852 31/18722 0.0505507115341024 0.191871592120013 SERPINE1/TNFAIP3/ARHGEF2/PEA15 4 GO:0010959 regulation of metal ion transport 26/852 406/18722 0.050773496047101 0.19257197106636 SERPINE2/RRAD/ITGB1/PRSS8/TSPO/FXYD5/PTK2B/KCNJ2/SESTD1/FLNA/GLRX/CCR1/CD63/PKP2/WFS1/CTNNB1/DNM2/UBASH3B/LGALS3/ACTN4/P2RX4/TMBIM6/PTPN3/AHNAK/FMR1/SRI 26 GO:0034614 cellular response to reactive oxygen species 12/852 155/18722 0.0508363643211639 0.192641851837735 TPM1/IL18BP/MMP2/PXN/PYCR1/ENDOG/SOD3/TNFAIP3/PINK1/PLEKHA1/TXN/MAPK3 12 GO:0046323 glucose import 7/852 74/18722 0.0509460765723635 0.192641851837735 PRKAG2/ASPSCR1/INSR/PEA15/OPN3/PIK3R1/RTN2 7 GO:0120192 tight junction assembly 7/852 74/18722 0.0509460765723635 0.192641851837735 F11R/CLDN19/ESAM/GRHL2/MTDH/LSR/MYO1C 7 GO:0030042 actin filament depolymerization 6/852 59/18722 0.0509832995525261 0.192641851837735 SEMA5A/CAPG/LIMA1/DSTN/MICAL3/GSN 6 GO:0090303 positive regulation of wound healing 6/852 59/18722 0.0509832995525261 0.192641851837735 SERPINE1/ITGB1/XBP1/PLPP3/PTK2/RREB1 6 GO:0061097 regulation of protein tyrosine kinase activity 8/852 90/18722 0.052309800334593 0.196009085533574 SH3BP5/GPRC5A/CSF1R/EFNA1/CBLB/ERBB3/ERRFI1/ADAM17 8 GO:0099175 regulation of postsynapse organization 8/852 90/18722 0.052309800334593 0.196009085533574 IL1RAP/PDLIM5/PTPRS/APOE/EFNA1/ADAM10/TIAM1/ARF4 8 GO:0035821 modulation of process of other organism 9/852 106/18722 0.0523943283037485 0.196009085533574 IFI27/APOE/INSR/PPIB/DAG1/CAV2/IGF2R/RXRA/FMR1 9 GO:0046822 regulation of nucleocytoplasmic transport 9/852 106/18722 0.0523943283037485 0.196009085533574 TCF7L2/IFI27/SMAD3/TGFB1/FLNA/TXN/PKIG/JUP/PIK3R1 9 GO:0090263 positive regulation of canonical Wnt signaling pathway 9/852 106/18722 0.0523943283037485 0.196009085533574 SFRP1/SEMA5A/SMAD3/TGFB1/SOX4/TNKS2/XIAP/JUP/CTDNEP1 9 GO:0022602 ovulation cycle process 5/852 45/18722 0.0525551463363127 0.196009085533574 NRIP1/ADAMTS1/PAM/TGFB2/PLEKHA1 5 GO:0031670 cellular response to nutrient 5/852 45/18722 0.0525551463363127 0.196009085533574 SFRP1/PTN/LPL/XBP1/NCOA1 5 GO:0044088 regulation of vacuole organization 5/852 45/18722 0.0525551463363127 0.196009085533574 GRN/SCARB2/PINK1/SEC22B/SH3GLB1 5 GO:0071364 cellular response to epidermal growth factor stimulus 5/852 45/18722 0.0525551463363127 0.196009085533574 ERBB2/ZFP36L1/IQGAP1/ID1/ERRFI1 5 GO:2000273 positive regulation of signaling receptor activity 5/852 45/18722 0.0525551463363127 0.196009085533574 ITGB1/EPHB2/IFNGR2/PINK1/ADAM17 5 GO:0006887 exocytosis 23/852 352/18722 0.0528225082071385 0.196009085533574 SYT8/SDC4/GATA2/CCR1/STXBP5/RAB8B/SDC1/TNFAIP2/SNAP23/MYH9/CTBP2/SDF4/TMED10/LAMP1/SCAMP1/S100A13/ARL8B/AP1G1/MICAL3/TMEM167A/FMR1/SYNGR2/ATP6AP1 23 GO:0006670 sphingosine metabolic process 3/852 19/18722 0.0528480685613074 0.196009085533574 PLPP3/SGPP1/GBA 3 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 3/852 19/18722 0.0528480685613074 0.196009085533574 SOX4/PLK2/TP53 3 GO:0010885 regulation of cholesterol storage 3/852 19/18722 0.0528480685613074 0.196009085533574 LPL/SCARB1/ABCA1 3 GO:0030050 vesicle transport along actin filament 3/852 19/18722 0.0528480685613074 0.196009085533574 MYO6/ACTN4/MYO1C 3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 3/852 19/18722 0.0528480685613074 0.196009085533574 TECR/ACSL4/ACSL3 3 GO:0042474 middle ear morphogenesis 3/852 19/18722 0.0528480685613074 0.196009085533574 NOG/INSIG1/NAGLU 3 GO:0044003 modulation by symbiont of host process 3/852 19/18722 0.0528480685613074 0.196009085533574 INSR/DAG1/RXRA 3 GO:0044827 modulation by host of viral genome replication 3/852 19/18722 0.0528480685613074 0.196009085533574 IFI27/PPIB/FMR1 3 GO:0051546 keratinocyte migration 3/852 19/18722 0.0528480685613074 0.196009085533574 IQSEC1/MAPRE2/ADAM9 3 GO:0140131 positive regulation of lymphocyte chemotaxis 3/852 19/18722 0.0528480685613074 0.196009085533574 PTK2B/ADAM10/ADAM17 3 GO:1900221 regulation of amyloid-beta clearance 3/852 19/18722 0.0528480685613074 0.196009085533574 ABCA7/APOE/LRP1 3 GO:1903204 negative regulation of oxidative stress-induced neuron death 3/852 19/18722 0.0528480685613074 0.196009085533574 CTNNB1/PINK1/ATF4 3 GO:1903975 regulation of glial cell migration 3/852 19/18722 0.0528480685613074 0.196009085533574 TIAM1/LRP1/P2RX4 3 GO:2000738 positive regulation of stem cell differentiation 3/852 19/18722 0.0528480685613074 0.196009085533574 PTN/TGFB2/LTBP3 3 GO:0001764 neuron migration 12/852 156/18722 0.0529045416826717 0.196074048813613 FGFR1/GATA3/NAV1/TUBB2A/PLXNB2/GATA2/FLNA/SRGAP2C/SRGAP2/ARHGEF2/CTNNB1/MDK 12 GO:0042113 B cell activation 22/852 334/18722 0.0533715889179639 0.197514122811847 ITGB1/SFRP1/PLCL2/TGFB1/PTK2B/INHA/EPHB2/XBP1/NOTCH2/MMP14/TNFAIP3/PKN1/CD320/HDAC5/KLF6/BST2/ZFP36L1/MIF/TP53/NDFIP1/PIK3R1/ADAM17 22 GO:0062012 regulation of small molecule metabolic process 22/852 334/18722 0.0533715889179639 0.197514122811847 IGF2/ADM/PRKAG2/POMC/APOC1/GUCA2A/PTK2B/APOE/MFSD2A/FAM3C/INSIG1/NCOR2/INSR/H6PD/FABP5/PINK1/LDLR/EGR1/PPP1CB/RDH10/TP53/DDB1 22 GO:0051656 establishment of organelle localization 25/852 390/18722 0.0540806045609131 0.199990949856779 ITGB1/GATA2/TMED2/AP3S1/WIPI1/SNAP23/CTNNB1/DNM2/PICALM/MYH9/TMED10/LAMP1/PINK1/MYO6/ACTN4/SUN2/SAR1A/S100A13/COPG1/TMED9/EZR/ARFGAP3/MYO1C/MAP4/ATP6AP1 25 GO:0021700 developmental maturation 19/852 280/18722 0.0543884785601747 0.200981800729339 EPAS1/GATA3/MMP2/ACVRL1/GATA2/TGFB2/NTN4/PTK2B/CD63/EDNRB/PTBP3/CTNNB1/GBA/PICALM/DAG1/CLN5/B4GALT5/AP1G1/ARCN1 19 GO:0031663 lipopolysaccharide-mediated signaling pathway 6/852 60/18722 0.0545674042139292 0.201199813486231 TGFB1/SCARB1/TNFAIP3/SASH1/MTDH/MAPK3 6 GO:0042306 regulation of protein import into nucleus 6/852 60/18722 0.0545674042139292 0.201199813486231 SMAD3/TGFB1/FLNA/PKIG/JUP/PIK3R1 6 GO:0051851 modulation by host of symbiont process 6/852 60/18722 0.0545674042139292 0.201199813486231 IFI27/APOE/PPIB/CAV2/IGF2R/FMR1 6 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 9/852 107/18722 0.0550097426392173 0.202456634035508 PTK2B/PLK2/GBA/ANKIB1/PTK2/HERPUD1/RNF144B/RNF139/CSNK1A1 9 GO:1902107 positive regulation of leukocyte differentiation 12/852 157/18722 0.0550289440414415 0.202456634035508 HLA-G/GATA3/TGFB1/SOX4/CCR1/XBP1/NOTCH2/MMP14/ZFP36L1/KLF10/MDK/ATP6AP1 12 GO:1903708 positive regulation of hemopoiesis 12/852 157/18722 0.0550289440414415 0.202456634035508 HLA-G/GATA3/TGFB1/SOX4/CCR1/XBP1/NOTCH2/MMP14/ZFP36L1/KLF10/MDK/ATP6AP1 12 GO:0006885 regulation of pH 8/852 91/18722 0.0551753052511644 0.202846830773638 SLC4A7/EDNRB/GRN/CLIC4/ATP6V0E1/CLN5/MAPK3/ATP6AP1 8 GO:0006026 aminoglycan catabolic process 4/852 32/18722 0.0557742182519572 0.203709463325182 TGFB1/NAGLU/GNS/GLB1 4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 4/852 32/18722 0.0557742182519572 0.203709463325182 CITED2/CDKN1C/ADAM17/TGFBR3 4 GO:0035767 endothelial cell chemotaxis 4/852 32/18722 0.0557742182519572 0.203709463325182 FGFR1/SEMA5A/HSPB1/P2RX4 4 GO:0048841 regulation of axon extension involved in axon guidance 4/852 32/18722 0.0557742182519572 0.203709463325182 SEMA5A/SEMA4C/BMPR2/SEMA7A 4 GO:0060323 head morphogenesis 4/852 32/18722 0.0557742182519572 0.203709463325182 NOG/MMP2/CRISPLD2/PLEKHA1 4 GO:0090140 regulation of mitochondrial fission 4/852 32/18722 0.0557742182519572 0.203709463325182 RALBP1/STAT2/INF2/PINK1 4 GO:1901889 negative regulation of cell junction assembly 4/852 32/18722 0.0557742182519572 0.203709463325182 ACVRL1/PHLDB2/MMP14/LRP1 4 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 4/852 32/18722 0.0557742182519572 0.203709463325182 CITED2/CDKN1C/ADAM17/TGFBR3 4 GO:1905476 negative regulation of protein localization to membrane 4/852 32/18722 0.0557742182519572 0.203709463325182 TGFB1/TMEM59/PICALM/LYPLA1 4 GO:0001819 positive regulation of cytokine production 29/852 467/18722 0.056499923273449 0.206125933389698 SERPINE1/EBI3/IL6ST/HLA-G/IL1R1/IL1RAP/GATA3/CD276/LPL/SMAD3/TGFB1/EPHB2/XBP1/CSF1R/HSPB1/ISG15/ARHGEF2/TMED10/EGR1/LRP1/NLRP2/MIF/SEMA7A/S100A13/FURIN/MDK/PIK3R1/ATF4/ADAM17 29 GO:0010508 positive regulation of autophagy 10/852 124/18722 0.0565177405280714 0.206125933389698 TMEM59/PLK2/SH3BP4/MTDH/DAPK1/PINK1/PAFAH1B2/PIK3CB/MAPK3/SH3GLB1 10 GO:0032924 activin receptor signaling pathway 5/852 46/18722 0.0568530011879999 0.206749389435841 FSTL3/CITED2/ACVRL1/SMAD3/BMPR2 5 GO:0045851 pH reduction 5/852 46/18722 0.0568530011879999 0.206749389435841 GRN/CLIC4/ATP6V0E1/CLN5/ATP6AP1 5 GO:0061462 protein localization to lysosome 5/852 46/18722 0.0568530011879999 0.206749389435841 SCARB2/SH3BP4/RTN4/LMBRD1/LAMP2 5 GO:1900271 regulation of long-term synaptic potentiation 5/852 46/18722 0.0568530011879999 0.206749389435841 PTN/APOE/EPHB2/NPTN/NCSTN 5 GO:0006809 nitric oxide biosynthetic process 7/852 76/18722 0.0573481773558915 0.208099045877579 TSPO/SMAD3/PTK2B/INSR/DNM2/P2RX4/CYB5R3 7 GO:0008652 cellular amino acid biosynthetic process 7/852 76/18722 0.0573481773558915 0.208099045877579 PLOD3/PLOD2/PYCR1/GLS/SERINC3/SLC1A3/BCAT1 7 GO:0043536 positive regulation of blood vessel endothelial cell migration 7/852 76/18722 0.0573481773558915 0.208099045877579 FGFR1/GATA2/TGFB1/HSPB1/PLK2/P2RX4/ADAM17 7 GO:0002832 negative regulation of response to biotic stimulus 9/852 108/18722 0.0577084907227846 0.209222793420828 HTRA1/HLA-G/SERPING1/GRN/ISG15/TNFAIP3/STAT2/SEC14L1/PCBP2 9 GO:0006417 regulation of translation 29/852 468/18722 0.057741001403046 0.209222793420828 DIO2/PLXNB2/ERBB2/MEX3D/PTK2B/SOX4/IGF2BP2/RPS27L/GCN1/HSPB1/TMED2/EIF4EBP1/CALR/EIF4EBP2/PABPC1/DAPK1/EIF4G2/PINK1/ZFP36L1/LTN1/ASCC2/MAPK3/RNF139/PPP1R15B/FMR1/ATF4/IGF2BP3/EIF4B/DNAJC3 29 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 14/852 193/18722 0.0580362844955777 0.210141453141182 IGF2/IL6ST/ITGA5/CSH1/TGFB1/PTK2B/CSF1R/EFNA1/ARHGEF2/ERBB3/MIF/IQGAP1/TP53/ADAM17 14 GO:0043954 cellular component maintenance 6/852 61/18722 0.058300088539738 0.210713729525429 APOE/CSF1R/INSR/CTBP2/SDF4/CTTN 6 GO:0090342 regulation of cell aging 6/852 61/18722 0.058300088539738 0.210713729525429 HLA-G/NUAK1/PLK2/YPEL3/MIF/TP53 6 GO:0008202 steroid metabolic process 21/852 319/18722 0.0583199334847848 0.210713729525429 ADM/HSD3B1/TSPO/PRKAG2/APOC1/APOE/SCARB1/LIMA1/INSIG1/CYP11A1/ABCA1/NPC2/H6PD/GBA/LDLR/PLEKHA1/EGR1/RXRA/HDLBP/CYB5R3/CYB5R1 21 GO:0071621 granulocyte chemotaxis 10/852 125/18722 0.0590537905089388 0.213059302961641 ITGA1/TGFB2/CSF1R/PPIB/PTK2/LGALS3/MAPK3/BSG/MDK/DPP4 10 GO:2000027 regulation of animal organ morphogenesis 10/852 125/18722 0.0590537905089388 0.213059302961641 NOG/SFRP1/CITED2/GATA3/NTN4/GPC4/TIAM1/CTNNB1/MAGED1/BTBD7 10 GO:0071695 anatomical structure maturation 16/852 229/18722 0.0593149639941165 0.213848290675063 EPAS1/GATA3/MMP2/ACVRL1/GATA2/TGFB2/NTN4/PTK2B/EDNRB/PTBP3/CTNNB1/GBA/DAG1/CLN5/B4GALT5/ARCN1 16 GO:0072006 nephron development 11/852 142/18722 0.0595546523511208 0.214558743939292 NOG/GATA3/WWTR1/NOTCH2/LAMB2/CTNNB1/SEC61A1/LAMA5/EGR1/MAGED1/IQGAP1 11 GO:0050777 negative regulation of immune response 14/852 194/18722 0.0600643062727493 0.214676952025619 HTRA1/HLA-G/SERPING1/GRN/CD59/ISG15/TNFAIP3/PLK2/STAT2/LGALS3/FURIN/NDFIP1/SEC14L1/PCBP2 14 GO:0000272 polysaccharide catabolic process 3/852 20/18722 0.0601419635120451 0.214676952025619 GAA/PPP1CB/PYGL 3 GO:0003215 cardiac right ventricle morphogenesis 3/852 20/18722 0.0601419635120451 0.214676952025619 GATA3/TGFB2/SOX4 3 GO:0006590 thyroid hormone generation 3/852 20/18722 0.0601419635120451 0.214676952025619 DIO2/GATA3/CTSB 3 GO:0006896 Golgi to vacuole transport 3/852 20/18722 0.0601419635120451 0.214676952025619 AP3S1/LAMP1/AP1G1 3 GO:0034104 negative regulation of tissue remodeling 3/852 20/18722 0.0601419635120451 0.214676952025619 SFRP1/TNFAIP3/UBASH3B 3 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 3/852 20/18722 0.0601419635120451 0.214676952025619 ITM2B/ABCA7/ITM2C 3 GO:0043555 regulation of translation in response to stress 3/852 20/18722 0.0601419635120451 0.214676952025619 TMED2/PPP1R15B/DNAJC3 3 GO:0048670 regulation of collateral sprouting 3/852 20/18722 0.0601419635120451 0.214676952025619 CRABP2/PTPRS/LRP1 3 GO:0061318 renal filtration cell differentiation 3/852 20/18722 0.0601419635120451 0.214676952025619 NOTCH2/LAMB2/IQGAP1 3 GO:0072112 glomerular visceral epithelial cell differentiation 3/852 20/18722 0.0601419635120451 0.214676952025619 NOTCH2/LAMB2/IQGAP1 3 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 3/852 20/18722 0.0601419635120451 0.214676952025619 PYCR1/PINK1/TXN 3 GO:2000479 regulation of cAMP-dependent protein kinase activity 3/852 20/18722 0.0601419635120451 0.214676952025619 PRKAG2/PKIG/PRKAR2A 3 GO:0072009 nephron epithelium development 9/852 109/18722 0.0604911386420131 0.215770305304927 NOG/GATA3/WWTR1/NOTCH2/LAMB2/CTNNB1/LAMA5/MAGED1/IQGAP1 9 GO:0048644 muscle organ morphogenesis 7/852 77/18722 0.0607274905168295 0.21621702533419 TPM1/ENG/NOG/TGFB1/TGFB2/PKP2/TGFBR3 7 GO:0055117 regulation of cardiac muscle contraction 7/852 77/18722 0.0607274905168295 0.21621702533419 KCNJ2/PKP2/DSG2/GJA5/P2RX4/JUP/SRI 7 GO:0106027 neuron projection organization 8/852 93/18722 0.0612013906431025 0.21621702533419 PDLIM5/APOE/EPHB2/EFNA1/INSR/ADAM10/TIAM1/CTTN 8 GO:0002335 mature B cell differentiation 4/852 33/18722 0.061276570274095 0.21621702533419 PLCL2/PTK2B/XBP1/NOTCH2 4 GO:0006891 intra-Golgi vesicle-mediated transport 4/852 33/18722 0.061276570274095 0.21621702533419 COG6/COPA/COPG1/CUX1 4 GO:0010165 response to X-ray 4/852 33/18722 0.061276570274095 0.21621702533419 SFRP1/GATA3/DNM2/TP53 4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 4/852 33/18722 0.061276570274095 0.21621702533419 FLT1/TGFB1/PTK2B/PTK2 4 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 4/852 33/18722 0.061276570274095 0.21621702533419 SRGAP2C/DNM2/EVL/MAP4 4 GO:1903146 regulation of autophagy of mitochondrion 4/852 33/18722 0.061276570274095 0.21621702533419 TSPO/PINK1/CTTN/TP53 4 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/852 33/18722 0.061276570274095 0.21621702533419 CAMK2N1/CDKN1C/TNFAIP3/IPO7 4 GO:0010761 fibroblast migration 5/852 47/18722 0.0613466942533724 0.21621702533419 ITGB1/SDC4/TGFB1/PTK2/ARHGEF7 5 GO:0014911 positive regulation of smooth muscle cell migration 5/852 47/18722 0.0613466942533724 0.21621702533419 ADAMTS1/DOCK5/LRP1/IQGAP1/MDK 5 GO:0035315 hair cell differentiation 5/852 47/18722 0.0613466942533724 0.21621702533419 SLC4A7/CTNNB1/MYCL/MYO6/MYCN 5 GO:0045601 regulation of endothelial cell differentiation 5/852 47/18722 0.0613466942533724 0.21621702533419 F11R/ACVRL1/CTNNB1/VCL/ID1 5 GO:0046677 response to antibiotic 5/852 47/18722 0.0613466942533724 0.21621702533419 AOC1/ENDOG/JAK1/TP53/SLC1A3 5 GO:0101023 vascular endothelial cell proliferation 5/852 47/18722 0.0613466942533724 0.21621702533419 IGF2/FLT1/FGFR1/MDK/ADAM17 5 GO:1905562 regulation of vascular endothelial cell proliferation 5/852 47/18722 0.0613466942533724 0.21621702533419 IGF2/FLT1/FGFR1/MDK/ADAM17 5 GO:0090316 positive regulation of intracellular protein transport 12/852 160/18722 0.0617440456377911 0.217465207624215 TCF7L2/ERBB2/SMAD3/TGFB1/FLNA/RHOU/PINK1/SAR1A/JUP/PIK3R1/MYO1C/SH3GLB1 12 GO:0032835 glomerulus development 6/852 62/18722 0.062181717191473 0.217939124390448 NOG/WWTR1/NOTCH2/LAMB2/EGR1/IQGAP1 6 GO:0045428 regulation of nitric oxide biosynthetic process 6/852 62/18722 0.062181717191473 0.217939124390448 TSPO/SMAD3/PTK2B/INSR/DNM2/P2RX4 6 GO:0046824 positive regulation of nucleocytoplasmic transport 6/852 62/18722 0.062181717191473 0.217939124390448 TCF7L2/SMAD3/TGFB1/FLNA/JUP/PIK3R1 6 GO:0046847 filopodium assembly 6/852 62/18722 0.062181717191473 0.217939124390448 SRGAP2C/MYO10/SRGAP2/EZR/PIK3R1/FMR1 6 GO:0048488 synaptic vesicle endocytosis 6/852 62/18722 0.062181717191473 0.217939124390448 SYT8/ACTB/CANX/DNM2/PICALM/SH3GL1 6 GO:0060113 inner ear receptor cell differentiation 6/852 62/18722 0.062181717191473 0.217939124390448 SLC4A7/SDC4/NAGLU/MYCL/MYO6/MYCN 6 GO:0140238 presynaptic endocytosis 6/852 62/18722 0.062181717191473 0.217939124390448 SYT8/ACTB/CANX/DNM2/PICALM/SH3GL1 6 GO:0019221 cytokine-mediated signaling pathway 29/852 472/18722 0.0629011986658571 0.220307399363437 EBI3/IL6ST/CSF2RB/IL1R1/IL2RB/IL1RAP/P4HB/IL1R2/IFI27/PTK2B/UGCG/KRT8/CCR1/CSF1R/ISG15/TNFAIP3/IFNGR2/LIFR/STAT2/JAK1/EGR1/MAPK3/ACKR2/ACTN4/TP53/IFNAR1/UBE2K/KRT18/ADAM17 29 GO:0014812 muscle cell migration 9/852 110/18722 0.0633581831457701 0.221753641010195 TPM1/SERPINE1/IGFBP3/ADAMTS1/DOCK5/PARVA/LRP1/IQGAP1/MDK 9 GO:0045664 regulation of neuron differentiation 14/852 196/18722 0.064262705632232 0.224763167093137 TIMP2/FGFR1/SFRP1/GATA2/EDNRB/ARHGEF2/CALR/TIAM1/NCOA1/MYCL/YWHAG/MYCN/CTDSP1/TUG1 14 GO:0051702 biological process involved in interaction with symbiont 8/852 94/18722 0.06436303460913 0.224801633024116 FN1/IFI27/APOE/PPIB/CAV2/IGF2R/DDB1/FMR1 8 GO:0061326 renal tubule development 8/852 94/18722 0.06436303460913 0.224801633024116 COL4A1/NOG/GATA3/WWTR1/NOTCH2/CTNNB1/LAMA5/MAGED1 8 GO:0010821 regulation of mitochondrion organization 11/852 144/18722 0.0645125707548658 0.224855795435761 TNFSF10/TSPO/VAT1/RALBP1/STAT2/INF2/PINK1/TMEM14A/CTTN/TP53/GOLPH3 11 GO:0106106 cold-induced thermogenesis 11/852 144/18722 0.0645125707548658 0.224855795435761 DIO2/EPAS1/PLAC8/PLCL2/MFAP2/TLE3/FABP5/RHEB/ID1/ATF4/ADAM17 11 GO:0120161 regulation of cold-induced thermogenesis 11/852 144/18722 0.0645125707548658 0.224855795435761 DIO2/EPAS1/PLAC8/PLCL2/MFAP2/TLE3/FABP5/RHEB/ID1/ATF4/ADAM17 11 GO:0072330 monocarboxylic acid biosynthetic process 15/852 214/18722 0.0648371410886908 0.225830678961509 PTGES/PRKAG2/APOC1/LPL/XBP1/FADS3/INSIG1/TECR/MGLL/LIPG/FABP5/MIF/GPX4/RDH10/ACSL3 15 GO:0097720 calcineurin-mediated signaling 5/852 48/18722 0.0660356358411991 0.22984602710149 FHL2/RCAN1/PPP3CA/CAMTA1/NFAT5 5 GO:0030239 myofibril assembly 6/852 63/18722 0.0662124186014919 0.229984197944312 TPM1/ITGB1/KRT19/KRT8/CSRP1/OBSL1 6 GO:0050854 regulation of antigen receptor-mediated signaling pathway 6/852 63/18722 0.0662124186014919 0.229984197944312 PLCL2/CMTM3/CBLB/DGKZ/LGALS3/EZR 6 GO:1904589 regulation of protein import 6/852 63/18722 0.0662124186014919 0.229984197944312 SMAD3/TGFB1/FLNA/PKIG/JUP/PIK3R1 6 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 9/852 111/18722 0.066310050861622 0.230164473094168 FN1/SERPINE2/FLT1/FGFR1/TGFB2/INSR/PTK2/ERBB3/MYDGF 9 GO:0071248 cellular response to metal ion 14/852 197/18722 0.0664336990934002 0.230434739860154 AOC1/FSTL3/SYT8/TSPO/MT1X/ENDOG/CLIC4/CALR/ADCY7/FOSB/MAPK3/IQGAP1/P2RX4/NCSTN 14 GO:0016242 negative regulation of macroautophagy 4/852 34/18722 0.067054525684746 0.231457936249419 QSOX1/PINK1/TP53/SEC22B 4 GO:0032770 positive regulation of monooxygenase activity 4/852 34/18722 0.067054525684746 0.231457936249419 PTK2B/APOE/SCARB1/PIK3CB 4 GO:0070884 regulation of calcineurin-NFAT signaling cascade 4/852 34/18722 0.067054525684746 0.231457936249419 FHL2/RCAN1/CAMTA1/NFAT5 4 GO:0090075 relaxation of muscle 4/852 34/18722 0.067054525684746 0.231457936249419 KCNJ2/P2RX4/GSN/SRI 4 GO:1990000 amyloid fibril formation 4/852 34/18722 0.067054525684746 0.231457936249419 APOE/LDLR/FURIN/GSN 4 GO:0032496 response to lipopolysaccharide 22/852 343/18722 0.0670941130797131 0.231457936249419 SERPINE1/HPGD/SPARC/CSF2RB/TFPI/ADM/PTGES/IL18BP/TSPO/TGFB1/SCARB1/EDNRB/XBP1/TNFAIP3/SASH1/ABCA1/ADAM9/MTDH/MAPK3/CAPN2/IFNAR1/ADAM17 22 GO:0032612 interleukin-1 production 10/852 128/18722 0.0671018544960655 0.231457936249419 IL1R2/LPL/SMAD3/HSPB1/TNFAIP3/TMED10/EGR1/NLRP2/S100A13/ERRFI1 10 GO:0032652 regulation of interleukin-1 production 10/852 128/18722 0.0671018544960655 0.231457936249419 IL1R2/LPL/SMAD3/HSPB1/TNFAIP3/TMED10/EGR1/NLRP2/S100A13/ERRFI1 10 GO:0006942 regulation of striated muscle contraction 8/852 95/18722 0.0676242898024198 0.231457936249419 KCNJ2/PKP2/DSG2/GJA5/C12orf57/P2RX4/JUP/SRI 8 GO:0036473 cell death in response to oxidative stress 8/852 95/18722 0.0676242898024198 0.231457936249419 P4HB/PYCR1/ENDOG/HSPB1/CTNNB1/PINK1/TXN/ATF4 8 GO:0010878 cholesterol storage 3/852 21/18722 0.0678783854369445 0.231457936249419 LPL/SCARB1/ABCA1 3 GO:0021533 cell differentiation in hindbrain 3/852 21/18722 0.0678783854369445 0.231457936249419 NOG/GATA2/HERC1 3 GO:0030502 negative regulation of bone mineralization 3/852 21/18722 0.0678783854369445 0.231457936249419 PTK2B/CCR1/LTBP3 3 GO:0035455 response to interferon-alpha 3/852 21/18722 0.0678783854369445 0.231457936249419 GATA3/BST2/IFNAR1 3 GO:0038083 peptidyl-tyrosine autophosphorylation 3/852 21/18722 0.0678783854369445 0.231457936249419 PTK2B/MAPK3/IQGAP1 3 GO:0046519 sphingoid metabolic process 3/852 21/18722 0.0678783854369445 0.231457936249419 PLPP3/SGPP1/GBA 3 GO:0046885 regulation of hormone biosynthetic process 3/852 21/18722 0.0678783854369445 0.231457936249419 ADM/H6PD/EGR1 3 GO:0048485 sympathetic nervous system development 3/852 21/18722 0.0678783854369445 0.231457936249419 GATA3/SOX4/CTNNB1 3 GO:0072311 glomerular epithelial cell differentiation 3/852 21/18722 0.0678783854369445 0.231457936249419 NOTCH2/LAMB2/IQGAP1 3 GO:0090026 positive regulation of monocyte chemotaxis 3/852 21/18722 0.0678783854369445 0.231457936249419 SERPINE1/PLA2G7/CCR1 3 GO:0097062 dendritic spine maintenance 3/852 21/18722 0.0678783854369445 0.231457936249419 APOE/INSR/CTTN 3 GO:0098856 intestinal lipid absorption 3/852 21/18722 0.0678783854369445 0.231457936249419 UGCG/LIMA1/LDLR 3 GO:0150146 cell junction disassembly 3/852 21/18722 0.0678783854369445 0.231457936249419 IQSEC1/MAPRE2/PIK3R1 3 GO:1902307 positive regulation of sodium ion transmembrane transport 3/852 21/18722 0.0678783854369445 0.231457936249419 GLRX/DNM2/ACTN4 3 GO:1902473 regulation of protein localization to synapse 3/852 21/18722 0.0678783854369445 0.231457936249419 GPC4/ADAM10/DAG1 3 GO:0090257 regulation of muscle system process 17/852 252/18722 0.0689183344588686 0.234844940644201 TPM1/IL6ST/DOCK5/SMAD3/KCNJ2/PKP2/FBXO32/DSG2/GJA5/DAG1/C12orf57/CTTN/PPP3CA/P2RX4/JUP/ERRFI1/SRI 17 GO:0034101 erythrocyte homeostasis 10/852 129/18722 0.0699324885951701 0.237978509195058 EPAS1/CITED2/GATA3/GATA2/INHA/PTBP3/ISG15/ZFP36L1/RBFOX2/TGFBR3 10 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 10/852 129/18722 0.0699324885951701 0.237978509195058 TNFSF10/EGLN3/SMAD3/HIP1/RPS27L/DAP/DAPK1/NLRP2/CTSH/GSN 10 GO:0030104 water homeostasis 6/852 64/18722 0.0703920875655769 0.239057609121153 UGCG/WFS1/GBA/LSR/EXT2/GRHL1 6 GO:0050771 negative regulation of axonogenesis 6/852 64/18722 0.0703920875655769 0.239057609121153 SEMA5A/PTPRS/EPHB2/SEMA4C/RTN4/SEMA7A 6 GO:0080164 regulation of nitric oxide metabolic process 6/852 64/18722 0.0703920875655769 0.239057609121153 TSPO/SMAD3/PTK2B/INSR/DNM2/P2RX4 6 GO:0006692 prostanoid metabolic process 5/852 49/18722 0.0709188333848635 0.239072669518546 HPGD/PTGES/ACOX1/FABP5/MIF 5 GO:0006693 prostaglandin metabolic process 5/852 49/18722 0.0709188333848635 0.239072669518546 HPGD/PTGES/ACOX1/FABP5/MIF 5 GO:0009409 response to cold 5/852 49/18722 0.0709188333848635 0.239072669518546 PLAC8/ADM/LPL/PCSK1N/DNAJC3 5 GO:0010823 negative regulation of mitochondrion organization 5/852 49/18722 0.0709188333848635 0.239072669518546 TSPO/VAT1/PINK1/TMEM14A/TP53 5 GO:0030225 macrophage differentiation 5/852 49/18722 0.0709188333848635 0.239072669518546 GATA2/TGFB1/INHA/CSF1R/GBA 5 GO:0030857 negative regulation of epithelial cell differentiation 5/852 49/18722 0.0709188333848635 0.239072669518546 ACVRL1/GRHL2/CTNNB1/SRSF6/ID1 5 GO:0034332 adherens junction organization 5/852 49/18722 0.0709188333848635 0.239072669518546 ACTB/ADAM10/CTNNB1/ZNF703/VCL 5 GO:1904752 regulation of vascular associated smooth muscle cell migration 5/852 49/18722 0.0709188333848635 0.239072669518546 TPM1/ADAMTS1/DOCK5/LRP1/IQGAP1 5 GO:0003073 regulation of systemic arterial blood pressure 8/852 96/18722 0.0709854393096818 0.239072669518546 TPM1/ADM/PRCP/CAMK2N1/NAV2/BMPR2/GJA5/CTSZ 8 GO:0042158 lipoprotein biosynthetic process 8/852 96/18722 0.0709854393096818 0.239072669518546 ZDHHC9/APOE/UGCG/PIGT/ABCA1/WIPI1/GBA/GPAA1 8 GO:0002700 regulation of production of molecular mediator of immune response 12/852 164/18722 0.0715097254586349 0.239072669518546 HLA-G/IL1R1/GATA3/TGFB1/TGFB2/EPHB2/XBP1/PKN1/BST2/SEMA7A/NDFIP1/TMBIM6 12 GO:0050806 positive regulation of synaptic transmission 12/852 164/18722 0.0715097254586349 0.239072669518546 SERPINE2/PTN/RASGRF2/PTK2B/APOE/EPHB2/PLK2/PINK1/NPTN/SLC1A3/NCSTN/FMR1 12 GO:2001242 regulation of intrinsic apoptotic signaling pathway 12/852 164/18722 0.0715097254586349 0.239072669518546 P4HB/XBP1/HSPB1/WFS1/ARHGEF2/PINK1/MIF/HERPUD1/SERINC3/TP53/TMBIM6/ERP29 12 GO:0001570 vasculogenesis 7/852 80/18722 0.0715833494741361 0.239072669518546 ENG/ADM/CITED2/TGFB1/CTNNB1/ZFP36L1/TGFBR3 7 GO:0009791 post-embryonic development 7/852 80/18722 0.0715833494741361 0.239072669518546 FBN1/GATA3/MFAP2/PLEKHA1/C12orf57/IGF2R/INPPL1 7 GO:0120193 tight junction organization 7/852 80/18722 0.0715833494741361 0.239072669518546 F11R/CLDN19/ESAM/GRHL2/MTDH/LSR/MYO1C 7 GO:1901264 carbohydrate derivative transport 7/852 80/18722 0.0715833494741361 0.239072669518546 PSAP/SLC35A3/MFSD2A/SCARB1/RALBP1/NPC2/SLC15A3 7 GO:0034504 protein localization to nucleus 19/852 290/18722 0.0716410652038313 0.239072669518546 SMAD3/WWTR1/ABCA7/TGFB1/FLNA/SYNE1/CALR/TOR1AIP2/CBLB/TXN/PKIG/MAGED1/SUN2/PPP3CA/TP53/JUP/PIK3R1/IPO7/CTDNEP1 19 GO:0048872 homeostasis of number of cells 18/852 272/18722 0.0723775536888977 0.239072669518546 FSTL1/EPAS1/CITED2/GATA3/GATA2/INHA/SOX4/PTBP3/ISG15/TNFAIP3/PKN1/GBA/ZFP36L1/PIK3CB/RBFOX2/NCSTN/ADAM17/TGFBR3 18 GO:0042476 odontogenesis 10/852 130/18722 0.0728376184738986 0.239072669518546 HTRA1/SERPINE1/ADM/PAM/TGFB2/ID3/SDC1/CTNNB1/LAMA5/BSG 10 GO:0005984 disaccharide metabolic process 2/852 10/18722 0.0730446547977501 0.239072669518546 GAA/B4GALT1 2 GO:0009750 response to fructose 2/852 10/18722 0.0730446547977501 0.239072669518546 XBP1/KRT18 2 GO:0009950 dorsal/ventral axis specification 2/852 10/18722 0.0730446547977501 0.239072669518546 SFRP1/CTNNB1 2 GO:0010172 embryonic body morphogenesis 2/852 10/18722 0.0730446547977501 0.239072669518546 PHLDB2/DAG1 2 GO:0010992 ubiquitin recycling 2/852 10/18722 0.0730446547977501 0.239072669518546 PINK1/UBE2K 2 GO:0016139 glycoside catabolic process 2/852 10/18722 0.0730446547977501 0.239072669518546 GBA/FUCA2 2 GO:0033572 transferrin transport 2/852 10/18722 0.0730446547977501 0.239072669518546 DNM2/ARHGAP1 2 GO:0035646 endosome to melanosome transport 2/852 10/18722 0.0730446547977501 0.239072669518546 CD63/AP1G1 2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 2/852 10/18722 0.0730446547977501 0.239072669518546 GATA3/GDF15 2 GO:0035907 dorsal aorta development 2/852 10/18722 0.0730446547977501 0.239072669518546 ENG/ACVRL1 2 GO:0040015 negative regulation of multicellular organism growth 2/852 10/18722 0.0730446547977501 0.239072669518546 PLAC8/GDF15 2 GO:0042989 sequestering of actin monomers 2/852 10/18722 0.0730446547977501 0.239072669518546 TMSB10/GSN 2 GO:0042996 regulation of Golgi to plasma membrane protein transport 2/852 10/18722 0.0730446547977501 0.239072669518546 LYPLA1/ACSL3 2 GO:0043485 endosome to pigment granule transport 2/852 10/18722 0.0730446547977501 0.239072669518546 CD63/AP1G1 2 GO:0044848 biological phase 2/852 10/18722 0.0730446547977501 0.239072669518546 TGFB2/CTNNB1 2 GO:0048672 positive regulation of collateral sprouting 2/852 10/18722 0.0730446547977501 0.239072669518546 CRABP2/LRP1 2 GO:0048757 pigment granule maturation 2/852 10/18722 0.0730446547977501 0.239072669518546 CD63/AP1G1 2 GO:0060272 embryonic skeletal joint morphogenesis 2/852 10/18722 0.0730446547977501 0.239072669518546 NOG/CTNNB1 2 GO:0060439 trachea morphogenesis 2/852 10/18722 0.0730446547977501 0.239072669518546 CTNNB1/MAPK3 2 GO:0061299 retina vasculature morphogenesis in camera-type eye 2/852 10/18722 0.0730446547977501 0.239072669518546 COL4A1/CLIC4 2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 2/852 10/18722 0.0730446547977501 0.239072669518546 OS9/INSIG1 2 GO:0071073 positive regulation of phospholipid biosynthetic process 2/852 10/18722 0.0730446547977501 0.239072669518546 CAPN2/ACSL3 2 GO:0072378 blood coagulation, fibrin clot formation 2/852 10/18722 0.0730446547977501 0.239072669518546 FN1/FBLN1 2 GO:0097084 vascular associated smooth muscle cell development 2/852 10/18722 0.0730446547977501 0.239072669518546 ENG/ADM 2 GO:0098917 retrograde trans-synaptic signaling 2/852 10/18722 0.0730446547977501 0.239072669518546 DAG1/FABP5 2 GO:0140059 dendrite arborization 2/852 10/18722 0.0730446547977501 0.239072669518546 PTN/TPBG 2 GO:1902855 regulation of non-motile cilium assembly 2/852 10/18722 0.0730446547977501 0.239072669518546 DNM2/MAP4 2 GO:1903867 extraembryonic membrane development 2/852 10/18722 0.0730446547977501 0.239072669518546 HTRA1/TMED2 2 GO:1904338 regulation of dopaminergic neuron differentiation 2/852 10/18722 0.0730446547977501 0.239072669518546 SFRP1/TIAM1 2 GO:2000659 regulation of interleukin-1-mediated signaling pathway 2/852 10/18722 0.0730446547977501 0.239072669518546 IL1R1/IL1R2 2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/852 10/18722 0.0730446547977501 0.239072669518546 SMAD3/GSN 2 GO:0001569 branching involved in blood vessel morphogenesis 4/852 35/18722 0.0731040807448922 0.239072669518546 COL4A1/ENG/CTNNB1/MDK 4 GO:0010837 regulation of keratinocyte proliferation 4/852 35/18722 0.0731040807448922 0.239072669518546 NOTCH2/ZFP36L1/SRSF6/MDK 4 GO:0018149 peptide cross-linking 4/852 35/18722 0.0731040807448922 0.239072669518546 FN1/BGN/ABCA7/KRT10 4 GO:0043243 positive regulation of protein-containing complex disassembly 4/852 35/18722 0.0731040807448922 0.239072669518546 SEMA5A/INSR/GBA/DSTN 4 GO:0106056 regulation of calcineurin-mediated signaling 4/852 35/18722 0.0731040807448922 0.239072669518546 FHL2/RCAN1/CAMTA1/NFAT5 4 GO:2000403 positive regulation of lymphocyte migration 4/852 35/18722 0.0731040807448922 0.239072669518546 JAM2/PTK2B/ADAM10/ADAM17 4 GO:0048738 cardiac muscle tissue development 16/852 236/18722 0.0733232547246049 0.239633727940868 TPM1/ENG/NOG/ITGB1/CITED2/PDLIM5/TGFB1/TGFB2/PKP2/NOTCH2/CALR/FHL2/DSG2/GJA5/TGFBR3/OBSL1 16 GO:0050796 regulation of insulin secretion 12/852 165/18722 0.0740983009640502 0.242009570896862 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 12 GO:0032409 regulation of transporter activity 20/852 310/18722 0.0744691827725914 0.243063162707168 RRAD/ITGB1/FXYD5/RASGRF2/PTK2B/EPHB2/GLRX/ACTB/IFNGR2/DNM2/DAPK1/PINK1/NDFIP2/ACTN4/RXRA/NDFIP1/PTPN3/AHNAK/FMR1/SRI 20 GO:0014074 response to purine-containing compound 11/852 148/18722 0.0752137062884191 0.245016559061238 SPARC/PTK2B/HSP90B1/SDC1/CARM1/ZFP36L1/FOSB/BSG/ITPR2/P2RX4/EZR 11 GO:0097530 granulocyte migration 11/852 148/18722 0.0752137062884191 0.245016559061238 IL1R1/ITGA1/TGFB2/CSF1R/PPIB/PTK2/LGALS3/MAPK3/BSG/MDK/DPP4 11 GO:2001056 positive regulation of cysteine-type endopeptidase activity 11/852 148/18722 0.0752137062884191 0.245016559061238 TNFSF10/EGLN3/SMAD3/HIP1/RPS27L/DAP/DAPK1/TBC1D10A/NLRP2/CTSH/GSN 11 GO:0030641 regulation of cellular pH 7/852 81/18722 0.0754417671984157 0.245124863982974 SLC4A7/GRN/CLIC4/ATP6V0E1/CLN5/MAPK3/ATP6AP1 7 GO:0046209 nitric oxide metabolic process 7/852 81/18722 0.0754417671984157 0.245124863982974 TSPO/SMAD3/PTK2B/INSR/DNM2/P2RX4/CYB5R3 7 GO:0060968 regulation of gene silencing 7/852 81/18722 0.0754417671984157 0.245124863982974 TGFB1/NCOR2/MYCN/PPP3CA/TP53/FMR1/KCNQ1OT1 7 GO:1903533 regulation of protein targeting 7/852 81/18722 0.0754417671984157 0.245124863982974 ERBB2/RHOU/LMAN1/NUCB1/PINK1/MYO1C/SH3GLB1 7 GO:0051261 protein depolymerization 9/852 114/18722 0.0756777949455129 0.245172466674906 SEMA5A/CAPG/LIMA1/ARHGEF2/SH3GL1/DSTN/CCSAP/MICAL3/GSN 9 GO:0019827 stem cell population maintenance 10/852 131/18722 0.0758174779332082 0.245172466674906 ASCL2/NOG/SFRP1/PTN/GATA2/SOX4/NOTCH2/TAF5L/CTNNB1/KLF10 10 GO:0071709 membrane assembly 5/852 50/18722 0.0759949041123603 0.245172466674906 EPHB2/UGCG/PICALM/CAV2/REEP3 5 GO:1904738 vascular associated smooth muscle cell migration 5/852 50/18722 0.0759949041123603 0.245172466674906 TPM1/ADAMTS1/DOCK5/LRP1/IQGAP1 5 GO:0007413 axonal fasciculation 3/852 22/18722 0.0760409736696856 0.245172466674906 SEMA5A/EPHB2/RTN4 3 GO:0031281 positive regulation of cyclase activity 3/852 22/18722 0.0760409736696856 0.245172466674906 TIMP2/GUCA2A/MAPK3 3 GO:0035561 regulation of chromatin binding 3/852 22/18722 0.0760409736696856 0.245172466674906 CTBP2/MBD2/PPP3CA 3 GO:0045048 protein insertion into ER membrane 3/852 22/18722 0.0760409736696856 0.245172466674906 TRAM2/TRAM1/EMC10 3 GO:0106030 neuron projection fasciculation 3/852 22/18722 0.0760409736696856 0.245172466674906 SEMA5A/EPHB2/RTN4 3 GO:1901032 negative regulation of response to reactive oxygen species 3/852 22/18722 0.0760409736696856 0.245172466674906 PYCR1/PINK1/TXN 3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 3/852 22/18722 0.0760409736696856 0.245172466674906 XBP1/TP53/ATF4 3 GO:2000114 regulation of establishment of cell polarity 3/852 22/18722 0.0760409736696856 0.245172466674906 GATA3/PTK2B/GSN 3 GO:1902882 regulation of response to oxidative stress 8/852 98/18722 0.0780080533327623 0.251032309733883 P4HB/PYCR1/ENDOG/HSPB1/CTNNB1/PINK1/TXN/ATF4 8 GO:1904029 regulation of cyclin-dependent protein kinase activity 8/852 98/18722 0.0780080533327623 0.251032309733883 CAMK2N1/CDKN1C/ACTB/CCNG2/TNFAIP3/ADAM17/IPO7/CCNE1 8 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 8/852 98/18722 0.0780080533327623 0.251032309733883 XBP1/HSPB1/WFS1/ARHGEF2/PINK1/MIF/HERPUD1/TMBIM6 8 GO:0043270 positive regulation of ion transport 18/852 275/18722 0.0784522781421855 0.25230052133522 ITGB1/PRSS8/PTGES/TSPO/EPHB2/KCNJ2/FLNA/GLRX/CCR1/PKP2/IFNGR2/WFS1/DNM2/PINK1/LGALS3/ACTN4/P2RX4/SRI 18 GO:0046916 cellular transition metal ion homeostasis 9/852 115/18722 0.0789717992407734 0.253809109565015 SLC39A6/MT1X/SLC30A2/SLC39A8/ANKRD9/NDFIP1/SLC39A7/SRI/ATP6AP1 9 GO:0050918 positive chemotaxis 6/852 66/18722 0.0791967591845051 0.254115374555693 SEMA5A/SMAD3/PGF/LRP1/LGALS3/MIF 6 GO:0008543 fibroblast growth factor receptor signaling pathway 7/852 82/18722 0.0794199633234615 0.254115374555693 FGFR1/NOG/GATA3/GALNT3/CTNNB1/GPC1/NPTN 7 GO:2001057 reactive nitrogen species metabolic process 7/852 82/18722 0.0794199633234615 0.254115374555693 TSPO/SMAD3/PTK2B/INSR/DNM2/P2RX4/CYB5R3 7 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 4/852 36/18722 0.0794205213940204 0.254115374555693 CTSL/DNM2/CTSF/ARL8B 4 GO:0003203 endocardial cushion morphogenesis 4/852 36/18722 0.0794205213940204 0.254115374555693 ENG/NOG/ACVRL1/TGFB2 4 GO:0036314 response to sterol 4/852 36/18722 0.0794205213940204 0.254115374555693 TGFB1/INSIG1/ABCA1/DAG1 4 GO:0070873 regulation of glycogen metabolic process 4/852 36/18722 0.0794205213940204 0.254115374555693 IGF2/POMC/INSR/PPP1CB 4 GO:0002040 sprouting angiogenesis 13/852 185/18722 0.0802139755044125 0.256491066527134 ITGA5/ITGB1/ACVRL1/SEMA5A/GATA2/PTK2B/PARVA/PGF/PLK2/HDAC5/JAK1/PIK3CB/EPN2 13 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 15/852 221/18722 0.0803639750449929 0.256807546921555 PTK2B/APOE/EFNA1/PLK2/GBA/PINK1/ANKIB1/PTK2/HERPUD1/RNF144B/RNF139/CSNK1A1/UBE2K/FMR1/TMEM259 15 GO:0010874 regulation of cholesterol efflux 5/852 51/18722 0.0812620886852637 0.259183835458132 ABCA7/APOE/ABCA1/LRP1/RXRA 5 GO:0045668 negative regulation of osteoblast differentiation 5/852 51/18722 0.0812620886852637 0.259183835458132 NOG/SFRP1/SMAD3/ID3/CRIM1 5 GO:0071622 regulation of granulocyte chemotaxis 5/852 51/18722 0.0812620886852637 0.259183835458132 CSF1R/PTK2/MAPK3/MDK/DPP4 5 GO:0033209 tumor necrosis factor-mediated signaling pathway 8/852 99/18722 0.0816695839233003 0.260318566108911 PTK2B/KRT8/TNFAIP3/ACTN4/TP53/UBE2K/KRT18/ADAM17 8 GO:0010565 regulation of cellular ketone metabolic process 10/852 133/18722 0.0820020516845757 0.261212864638272 ADM/PRKAG2/APOC1/MFSD2A/INSIG1/NCOR2/H6PD/FABP5/EGR1/RDH10 10 GO:2000241 regulation of reproductive process 12/852 168/18722 0.082220876674515 0.261499087996366 SFRP1/CITED2/TIMP1/GCM1/ARHGDIB/SYDE1/PRDX4/EDNRB/B4GALT1/CALR/CTNNB1/MYH9 12 GO:0015749 monosaccharide transmembrane transport 9/852 116/18722 0.0823516897425472 0.261499087996366 PRKAG2/SLC23A2/ASPSCR1/INSR/PEA15/FABP5/OPN3/PIK3R1/RTN2 9 GO:0030326 embryonic limb morphogenesis 9/852 116/18722 0.0823516897425472 0.261499087996366 NOG/CRABP2/TGFB2/NOTCH2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 9 GO:0033559 unsaturated fatty acid metabolic process 9/852 116/18722 0.0823516897425472 0.261499087996366 HPGD/PTGES/FADS3/ACOX1/MGLL/FABP5/MIF/MAPK3/GPX4 9 GO:0035113 embryonic appendage morphogenesis 9/852 116/18722 0.0823516897425472 0.261499087996366 NOG/CRABP2/TGFB2/NOTCH2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 9 GO:0071478 cellular response to radiation 13/852 186/18722 0.0828499607058683 0.262749749358938 SFRP1/PTN/GATA3/TIMP1/MMP2/DNM2/EGR1/OPN3/TP53/DDB1/PIK3R1/FMR1/ATF4 13 GO:1902115 regulation of organelle assembly 13/852 186/18722 0.0828499607058683 0.262749749358938 IL1RAP/SDC4/PTPRS/PLK2/SDC1/DNM2/PINK1/CCSAP/EZR/SEC22B/GSN/MAP4/SH3GLB1 13 GO:0035914 skeletal muscle cell differentiation 6/852 67/18722 0.0838204153614439 0.26483800434141 CITED2/ATF3/EGR1/GPC1/KLF5/DDX17 6 GO:0042490 mechanoreceptor differentiation 6/852 67/18722 0.0838204153614439 0.26483800434141 SLC4A7/SDC4/NAGLU/MYCL/MYO6/MYCN 6 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 3/852 23/18722 0.0846121714663128 0.26483800434141 HIP1/CBLB/LRP1 3 GO:0035162 embryonic hemopoiesis 3/852 23/18722 0.0846121714663128 0.26483800434141 GATA3/GATA2/ATF4 3 GO:0035994 response to muscle stretch 3/852 23/18722 0.0846121714663128 0.26483800434141 CTNNB1/PTK2/GSN 3 GO:0051457 maintenance of protein location in nucleus 3/852 23/18722 0.0846121714663128 0.26483800434141 SYNE1/TXN/SUN2 3 GO:0060575 intestinal epithelial cell differentiation 3/852 23/18722 0.0846121714663128 0.26483800434141 IL6ST/KLF5/YIPF6 3 GO:0006066 alcohol metabolic process 22/852 353/18722 0.0849986641464132 0.26483800434141 TTR/PTK2B/GDPD3/APOE/SCARB1/LIMA1/IPMK/PLPP3/INSIG1/CYP11A1/ABCA1/NPC2/SGPP1/DHRS3/H6PD/GBA/LDLR/RXRA/HDLBP/CYB5R3/RDH10/IMPA2 22 GO:0098727 maintenance of cell number 10/852 134/18722 0.0852069637120409 0.26483800434141 ASCL2/NOG/SFRP1/PTN/GATA2/SOX4/NOTCH2/TAF5L/CTNNB1/KLF10 10 GO:0019218 regulation of steroid metabolic process 8/852 100/18722 0.08543114156039 0.26483800434141 ADM/TSPO/APOC1/APOE/INSIG1/H6PD/LDLR/EGR1 8 GO:0002695 negative regulation of leukocyte activation 13/852 187/18722 0.0855401961720162 0.26483800434141 HLA-G/SFRP1/SDC4/ERBB2/INHA/GRN/TNFAIP3/PKN1/CBLB/LDLR/LGALS3/NDFIP1/MDK 13 GO:0003176 aortic valve development 4/852 37/18722 0.0859984748428337 0.26483800434141 GATA3/TGFB1/EFNA1/BMPR2 4 GO:0014904 myotube cell development 4/852 37/18722 0.0859984748428337 0.26483800434141 SMYD3/RCAN1/CAV2/PPP3CA 4 GO:0016202 regulation of striated muscle tissue development 4/852 37/18722 0.0859984748428337 0.26483800434141 IGF2/SMAD3/TGFB1/CTNNB1 4 GO:0030513 positive regulation of BMP signaling pathway 4/852 37/18722 0.0859984748428337 0.26483800434141 ENG/ACVRL1/NOTCH2/BMPR2 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/852 37/18722 0.0859984748428337 0.26483800434141 IGF2/TGFB1/INSR/PPP1CB 4 GO:0042401 cellular biogenic amine biosynthetic process 4/852 37/18722 0.0859984748428337 0.26483800434141 GATA3/TGFB2/SAT1/AMD1 4 GO:0043403 skeletal muscle tissue regeneration 4/852 37/18722 0.0859984748428337 0.26483800434141 CD9/DAG1/PPP3CA/KLF5 4 GO:0048009 insulin-like growth factor receptor signaling pathway 4/852 37/18722 0.0859984748428337 0.26483800434141 IGFBP3/CRIM1/IGF2R/PIK3R1 4 GO:0048846 axon extension involved in axon guidance 4/852 37/18722 0.0859984748428337 0.26483800434141 SEMA5A/SEMA4C/BMPR2/SEMA7A 4 GO:0060428 lung epithelium development 4/852 37/18722 0.0859984748428337 0.26483800434141 RCN3/GRHL2/SRSF6/ERRFI1 4 GO:1902284 neuron projection extension involved in neuron projection guidance 4/852 37/18722 0.0859984748428337 0.26483800434141 SEMA5A/SEMA4C/BMPR2/SEMA7A 4 GO:0001660 fever generation 2/852 11/18722 0.0866596190455042 0.26483800434141 PTGES/EDNRB 2 GO:0002645 positive regulation of tolerance induction 2/852 11/18722 0.0866596190455042 0.26483800434141 HLA-G/CBLB 2 GO:0006702 androgen biosynthetic process 2/852 11/18722 0.0866596190455042 0.26483800434141 HSD3B1/SCARB1 2 GO:0006707 cholesterol catabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 APOE/SCARB1 2 GO:0007042 lysosomal lumen acidification 2/852 11/18722 0.0866596190455042 0.26483800434141 GRN/CLN5 2 GO:0009235 cobalamin metabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 CD320/LMBRD1 2 GO:0014854 response to inactivity 2/852 11/18722 0.0866596190455042 0.26483800434141 FBXO32/DAG1 2 GO:0016127 sterol catabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 APOE/SCARB1 2 GO:0019372 lipoxygenase pathway 2/852 11/18722 0.0866596190455042 0.26483800434141 HPGD/GPX4 2 GO:0032308 positive regulation of prostaglandin secretion 2/852 11/18722 0.0866596190455042 0.26483800434141 PTGES/P2RX4 2 GO:0032610 interleukin-1 alpha production 2/852 11/18722 0.0866596190455042 0.26483800434141 IL1R2/S100A13 2 GO:0032650 regulation of interleukin-1 alpha production 2/852 11/18722 0.0866596190455042 0.26483800434141 IL1R2/S100A13 2 GO:0032957 inositol trisphosphate metabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 PTK2B/IPMK 2 GO:0033210 leptin-mediated signaling pathway 2/852 11/18722 0.0866596190455042 0.26483800434141 EBI3/UGCG 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/852 11/18722 0.0866596190455042 0.26483800434141 PTPRS/RTN4 2 GO:0034650 cortisol metabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 CYP11A1/H6PD 2 GO:0035457 cellular response to interferon-alpha 2/852 11/18722 0.0866596190455042 0.26483800434141 GATA3/IFNAR1 2 GO:0042789 mRNA transcription by RNA polymerase II 2/852 11/18722 0.0866596190455042 0.26483800434141 FLNA/ATF4 2 GO:0043589 skin morphogenesis 2/852 11/18722 0.0866596190455042 0.26483800434141 GBA/ERRFI1 2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 2/852 11/18722 0.0866596190455042 0.26483800434141 EPAS1/ATF4 2 GO:0046349 amino sugar biosynthetic process 2/852 11/18722 0.0866596190455042 0.26483800434141 GFPT1/PGM3 2 GO:0048102 autophagic cell death 2/852 11/18722 0.0866596190455042 0.26483800434141 LAMP1/SH3GLB1 2 GO:0051132 NK T cell activation 2/852 11/18722 0.0866596190455042 0.26483800434141 ELF4/HSPH1 2 GO:0060742 epithelial cell differentiation involved in prostate gland development 2/852 11/18722 0.0866596190455042 0.26483800434141 PSAP/CTNNB1 2 GO:0070243 regulation of thymocyte apoptotic process 2/852 11/18722 0.0866596190455042 0.26483800434141 EFNA1/TP53 2 GO:0070778 L-aspartate transmembrane transport 2/852 11/18722 0.0866596190455042 0.26483800434141 SLC1A5/SLC1A3 2 GO:0071679 commissural neuron axon guidance 2/852 11/18722 0.0866596190455042 0.26483800434141 EPHB2/DAG1 2 GO:0075733 intracellular transport of virus 2/852 11/18722 0.0866596190455042 0.26483800434141 BST2/FMR1 2 GO:0090160 Golgi to lysosome transport 2/852 11/18722 0.0866596190455042 0.26483800434141 LAMP1/AP1G1 2 GO:0099550 trans-synaptic signaling, modulating synaptic transmission 2/852 11/18722 0.0866596190455042 0.26483800434141 EPHB2/NPTN 2 GO:0106049 regulation of cellular response to osmotic stress 2/852 11/18722 0.0866596190455042 0.26483800434141 ARHGEF2/EFHD1 2 GO:1902188 positive regulation of viral release from host cell 2/852 11/18722 0.0866596190455042 0.26483800434141 CAV2/DDB1 2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 2/852 11/18722 0.0866596190455042 0.26483800434141 UBE2K/ADAM17 2 GO:1903897 regulation of PERK-mediated unfolded protein response 2/852 11/18722 0.0866596190455042 0.26483800434141 ABCA7/PPP1R15B 2 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 2/852 11/18722 0.0866596190455042 0.26483800434141 LPL/LRP1 2 GO:2000392 regulation of lamellipodium morphogenesis 2/852 11/18722 0.0866596190455042 0.26483800434141 ARHGEF7/RREB1 2 GO:2000644 regulation of receptor catabolic process 2/852 11/18722 0.0866596190455042 0.26483800434141 APOE/FURIN 2 GO:0043090 amino acid import 5/852 52/18722 0.0867182656774575 0.26483800434141 ITGB1/SLC7A1/SFXN3/SLC1A5/SLC1A3 5 GO:0072132 mesenchyme morphogenesis 5/852 52/18722 0.0867182656774575 0.26483800434141 ENG/NOG/ACVRL1/SMAD3/TGFB2 5 GO:0015711 organic anion transport 22/852 354/18722 0.0869479842233605 0.265378535231154 ITGB1/PTGES/SLCO2A1/SLC4A7/PSAP/SLC39A8/SLC35A3/SLC23A2/SLC7A1/MFSD2A/SFXN3/SLC16A3/SLC1A5/SLC16A4/SLC17A5/SLC6A8/SERINC3/P2RX4/SLC1A3/MFSD12/SLC16A1/CYB5R1 22 GO:0002263 cell activation involved in immune response 18/852 279/18722 0.0870632062104787 0.265569161731721 GATA3/PLCL2/DNASE1L3/GATA2/TGFB1/PTK2B/GRN/XBP1/NOTCH2/SNAP23/LAMP1/LRP1/LGALS3/S100A13/AP1G1/TP53/NDFIP1/MDK 18 GO:0002088 lens development in camera-type eye 7/852 84/18722 0.0877343885309916 0.26729248031264 CITED2/GATA3/SMAD3/FAT1/CTNNB1/BCAR3/ATF4 7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7/852 84/18722 0.0877343885309916 0.26729248031264 SOX4/RPS27L/PLK2/JADE1/CTDSP1/TP53/WEE1 7 GO:0001101 response to acid chemical 10/852 135/18722 0.0884870004774722 0.269422306958934 COL4A1/PTN/MMP2/CD9/COL6A1/KRT8/XBP1/SH3BP4/CAPN2/TMBIM6 10 GO:0006576 cellular biogenic amine metabolic process 8/852 101/18722 0.0892925109703829 0.271546349071865 AOC1/EPAS1/GATA3/MAOA/TGFB2/GDPD3/SAT1/AMD1 8 GO:0098869 cellular oxidant detoxification 8/852 101/18722 0.0892925109703829 0.271546349071865 PTGES/APOE/GLRX/PRDX4/SOD3/GPX8/TXN/GPX4 8 GO:0007613 memory 9/852 118/18722 0.0893690440955817 0.271614975201125 PTN/ABCA7/APOE/INSR/PLK2/EIF4EBP2/RCAN1/LDLR/MDK 9 GO:0034284 response to monosaccharide 15/852 225/18722 0.0902330597058691 0.274075431200748 SPARC/TCF7L2/HMGN3/LPL/CAMK2N1/PTK2B/SOX4/ENDOG/XBP1/TIAM1/EGR1/LRP1/PPP3CA/KRT18/SRI 15 GO:0043401 steroid hormone mediated signaling pathway 10/852 136/18722 0.091842124973236 0.278794580814413 SFRP1/NCOR2/PKN1/CALR/CARM1/PAQR7/PGRMC2/RBFOX2/RXRA/DDX17 10 GO:0032092 positive regulation of protein binding 7/852 85/18722 0.0920696114529234 0.279316669344523 TCF7L2/PLCL2/APOE/PLK2/TIAM1/LRP1/AMFR 7 GO:0045806 negative regulation of endocytosis 5/852 53/18722 0.0923609667706301 0.279498614643126 APOC1/ABCA7/ANKRD13A/PICALM/LGALS3 5 GO:0097479 synaptic vesicle localization 5/852 53/18722 0.0923609667706301 0.279498614643126 AP3S1/CTNNB1/DNM2/PICALM/PINK1 5 GO:2000772 regulation of cellular senescence 5/852 53/18722 0.0923609667706301 0.279498614643126 HLA-G/NUAK1/PLK2/YPEL3/TP53 5 GO:0002478 antigen processing and presentation of exogenous peptide antigen 4/852 38/18722 0.0928319609037819 0.279498614643126 CTSL/TAP1/DNM2/CTSF 4 GO:0009309 amine biosynthetic process 4/852 38/18722 0.0928319609037819 0.279498614643126 GATA3/TGFB2/SAT1/AMD1 4 GO:0042491 inner ear auditory receptor cell differentiation 4/852 38/18722 0.0928319609037819 0.279498614643126 SLC4A7/MYCL/MYO6/MYCN 4 GO:1901031 regulation of response to reactive oxygen species 4/852 38/18722 0.0928319609037819 0.279498614643126 PYCR1/ENDOG/PINK1/TXN 4 GO:1901186 positive regulation of ERBB signaling pathway 4/852 38/18722 0.0928319609037819 0.279498614643126 HIP1/RTN4/BCAR3/ADAM17 4 GO:0045669 positive regulation of osteoblast differentiation 6/852 69/18722 0.0935053661141289 0.279498614643126 IL6ST/WWTR1/BMPR2/CTNNB1/FBN2/ATP6AP1 6 GO:0050810 regulation of steroid biosynthetic process 6/852 69/18722 0.0935053661141289 0.279498614643126 ADM/TSPO/APOE/INSIG1/H6PD/EGR1 6 GO:0001702 gastrulation with mouth forming second 3/852 24/18722 0.0935734483754556 0.279498614643126 UGDH/CTNNB1/ETS2 3 GO:0002021 response to dietary excess 3/852 24/18722 0.0935734483754556 0.279498614643126 GDF15/PCSK1N/APOE 3 GO:0010226 response to lithium ion 3/852 24/18722 0.0935734483754556 0.279498614643126 PTK2B/CALR/ADCY7 3 GO:0031639 plasminogen activation 3/852 24/18722 0.0935734483754556 0.279498614643126 SERPINE2/SERPINE1/CTSZ 3 GO:0032528 microvillus organization 3/852 24/18722 0.0935734483754556 0.279498614643126 FXYD5/KLF5/EZR 3 GO:0043302 positive regulation of leukocyte degranulation 3/852 24/18722 0.0935734483754556 0.279498614643126 GATA2/LAMP1/AP1G1 3 GO:0045649 regulation of macrophage differentiation 3/852 24/18722 0.0935734483754556 0.279498614643126 GATA2/TGFB1/INHA 3 GO:0048641 regulation of skeletal muscle tissue development 3/852 24/18722 0.0935734483754556 0.279498614643126 IGF2/TGFB1/CTNNB1 3 GO:0050687 negative regulation of defense response to virus 3/852 24/18722 0.0935734483754556 0.279498614643126 HTRA1/SEC14L1/PCBP2 3 GO:0060571 morphogenesis of an epithelial fold 3/852 24/18722 0.0935734483754556 0.279498614643126 NOG/CTNNB1/RDH10 3 GO:0071294 cellular response to zinc ion 3/852 24/18722 0.0935734483754556 0.279498614643126 TSPO/MT1X/P2RX4 3 GO:0072010 glomerular epithelium development 3/852 24/18722 0.0935734483754556 0.279498614643126 NOTCH2/LAMB2/IQGAP1 3 GO:0090343 positive regulation of cell aging 3/852 24/18722 0.0935734483754556 0.279498614643126 HLA-G/YPEL3/TP53 3 GO:0120255 olefinic compound biosynthetic process 3/852 24/18722 0.0935734483754556 0.279498614643126 ADM/H6PD/EGR1 3 GO:2000209 regulation of anoikis 3/852 24/18722 0.0935734483754556 0.279498614643126 ITGA5/ITGB1/PTK2 3 GO:2000679 positive regulation of transcription regulatory region DNA binding 3/852 24/18722 0.0935734483754556 0.279498614643126 GATA3/TGFB1/CTNNB1 3 GO:0048736 appendage development 12/852 172/18722 0.0938885076214518 0.280107207385161 NOG/PAM/CRABP2/TGFB2/SOX4/NOTCH2/BMPR2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 12 GO:0060173 limb development 12/852 172/18722 0.0938885076214518 0.280107207385161 NOG/PAM/CRABP2/TGFB2/SOX4/NOTCH2/BMPR2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 12 GO:0042886 amide transport 19/852 301/18722 0.0945093053110345 0.281792259259737 SFRP1/TCF7L2/HMGN3/PSAP/CAMK2N1/SOX4/TAP1/TAPBP/RAB8B/ABCA1/SGPP1/TIAM1/ACSL4/LRP1/SLC15A3/PPP3CA/SLC16A1/SRI/DPP4 19 GO:0009416 response to light stimulus 20/852 320/18722 0.0948755719711137 0.282549558420482 ITGB1/PTN/TIMP1/MMP2/ABCA7/DNM2/SCARA3/SDF4/OPN3/PPP1CB/NPTN/TP53/DDB1/GNAQ/SLC1A3/PIK3R1/TP53I13/FMR1/ATF4/UBE2A 20 GO:0016042 lipid catabolic process 20/852 320/18722 0.0948755719711137 0.282549558420482 HEXB/APOC1/PLA2G7/LPL/GDPD3/PLCD3/APOE/MFSD2A/SCARB1/GM2A/GBA/ACOX1/MGLL/LIPG/LDLR/PAFAH1B2/LRP1/HEXA/NEU1/IAH1 20 GO:0002697 regulation of immune effector process 21/852 339/18722 0.0950424403218025 0.282879126043544 HLA-G/IL1R1/SERPING1/GATA3/DNASE1L3/GATA2/TGFB1/TGFB2/PVR/EPHB2/GRN/XBP1/CD59/PKN1/LAMP1/BST2/LGALS3/SEMA7A/AP1G1/NDFIP1/TMBIM6 21 GO:0015833 peptide transport 17/852 264/18722 0.0954604762682333 0.283955423793155 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/TAP1/TAPBP/RAB8B/ABCA1/TIAM1/ACSL4/LRP1/SLC15A3/PPP3CA/SLC16A1/SRI/DPP4 17 GO:0071222 cellular response to lipopolysaccharide 14/852 209/18722 0.0963063873873929 0.286302449923655 SERPINE1/TFPI/TSPO/TGFB1/SCARB1/EDNRB/XBP1/TNFAIP3/SASH1/ABCA1/ADAM9/MTDH/MAPK3/CAPN2 14 GO:0009798 axis specification 7/852 86/18722 0.0965226046679281 0.286437658781652 SFRP1/CITED2/PCSK6/NOTCH2/TMED2/CTNNB1/ETS2 7 GO:0015908 fatty acid transport 7/852 86/18722 0.0965226046679281 0.286437658781652 PTGES/APOE/MFSD2A/FABP5/ACSL4/P2RX4/ACSL3 7 GO:0045921 positive regulation of exocytosis 7/852 86/18722 0.0965226046679281 0.286437658781652 SDC4/GATA2/STXBP5/SDC1/LAMP1/AP1G1/ATP6AP1 7 GO:0006694 steroid biosynthetic process 12/852 173/18722 0.0969553420362095 0.287552290199318 ADM/HSD3B1/TSPO/PRKAG2/APOE/SCARB1/INSIG1/CYP11A1/H6PD/EGR1/CYB5R3/CYB5R1 12 GO:0002027 regulation of heart rate 8/852 103/18722 0.0973133342625763 0.288104712555027 TPM1/EPAS1/ADM/KCNJ2/PKP2/DSG2/JUP/SRI 8 GO:0030148 sphingolipid biosynthetic process 8/852 103/18722 0.0973133342625763 0.288104712555027 UGCG/SGMS2/PLPP3/PRKD3/SGPP1/GBA/CERS6/B4GALT5 8 GO:0045639 positive regulation of myeloid cell differentiation 8/852 103/18722 0.0973133342625763 0.288104712555027 GATA2/TGFB1/CCR1/NOTCH2/ISG15/ZFP36L1/KLF10/ATP6AP1 8 GO:0007215 glutamate receptor signaling pathway 5/852 54/18722 0.0981873925498856 0.290010062619468 PTK2B/TIAM1/GNAQ/NCSTN/FMR1 5 GO:0030834 regulation of actin filament depolymerization 5/852 54/18722 0.0981873925498856 0.290010062619468 SEMA5A/CAPG/LIMA1/DSTN/GSN 5 GO:0032330 regulation of chondrocyte differentiation 5/852 54/18722 0.0981873925498856 0.290010062619468 ACVRL1/SMAD3/LTBP3/CTNNB1/MDK 5 GO:1902743 regulation of lamellipodium organization 5/852 54/18722 0.0981873925498856 0.290010062619468 NCKAP1/DNM2/ARHGEF7/PIK3R1/RREB1 5 GO:0070830 bicellular tight junction assembly 6/852 70/18722 0.098564027950867 0.290680891131707 F11R/CLDN19/ESAM/GRHL2/MTDH/MYO1C 6 GO:0035107 appendage morphogenesis 10/852 138/18722 0.0987772174740766 0.290680891131707 NOG/CRABP2/TGFB2/SOX4/NOTCH2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 10 GO:0035108 limb morphogenesis 10/852 138/18722 0.0987772174740766 0.290680891131707 NOG/CRABP2/TGFB2/SOX4/NOTCH2/GRHL2/CTNNB1/FBN2/MYCN/RDH10 10 GO:0015849 organic acid transport 19/852 303/18722 0.0991179542989751 0.290680891131707 ITGB1/PTGES/SLC23A2/SLC7A1/APOE/MFSD2A/SFXN3/SLC16A3/SLC1A5/SLC38A10/FABP5/ACSL4/SLC17A5/SERINC3/P2RX4/SLC1A3/MFSD12/SLC16A1/ACSL3 19 GO:0007623 circadian rhythm 14/852 210/18722 0.0991183322504466 0.290680891131707 NRIP1/ID3/GFPT1/NAGLU/EGR1/OPN3/PPP1CB/MAGED1/KLF10/TP53/DDB1/GNAQ/ID1/ATF4 14 GO:0007618 mating 4/852 39/18722 0.099914442753121 0.290680891131707 SERPINE2/HEXB/EDNRB/NCOA1 4 GO:0071548 response to dexamethasone 4/852 39/18722 0.099914442753121 0.290680891131707 SMYD3/FBXO32/GBA/ERRFI1 4 GO:0086091 regulation of heart rate by cardiac conduction 4/852 39/18722 0.099914442753121 0.290680891131707 KCNJ2/PKP2/DSG2/JUP 4 GO:1901861 regulation of muscle tissue development 4/852 39/18722 0.099914442753121 0.290680891131707 IGF2/SMAD3/TGFB1/CTNNB1 4 GO:0007584 response to nutrient 12/852 174/18722 0.100082104958644 0.290680891131707 SPARC/SFRP1/PTN/TSPO/LPL/XBP1/ABCA1/NCOA1/LIPG/ACSL4/SLC16A1/ACSL3 12 GO:0045619 regulation of lymphocyte differentiation 12/852 174/18722 0.100082104958644 0.290680891131707 HLA-G/SFRP1/GATA3/ERBB2/INHA/SOX4/XBP1/MMP14/ZFP36L1/NDFIP1/MDK/CLPTM1 12 GO:0071356 cellular response to tumor necrosis factor 15/852 229/18722 0.100836066249721 0.290680891131707 SFRP1/GATA3/IL18BP/PTK2B/KRT8/TNFAIP3/ARHGEF2/GBA/ZFP36L1/MAPK3/ACTN4/TP53/UBE2K/KRT18/ADAM17 15 GO:0002664 regulation of T cell tolerance induction 2/852 12/18722 0.100955731710356 0.290680891131707 HLA-G/CBLB 2 GO:0007614 short-term memory 2/852 12/18722 0.100955731710356 0.290680891131707 RCAN1/MDK 2 GO:0009886 post-embryonic animal morphogenesis 2/852 12/18722 0.100955731710356 0.290680891131707 FBN1/MFAP2 2 GO:0021781 glial cell fate commitment 2/852 12/18722 0.100955731710356 0.290680891131707 GCM1/CTNNB1 2 GO:0031953 negative regulation of protein autophosphorylation 2/852 12/18722 0.100955731710356 0.290680891131707 ENG/ERRFI1 2 GO:0032306 regulation of prostaglandin secretion 2/852 12/18722 0.100955731710356 0.290680891131707 PTGES/P2RX4 2 GO:0032736 positive regulation of interleukin-13 production 2/852 12/18722 0.100955731710356 0.290680891131707 IL1RAP/GATA3 2 GO:0033127 regulation of histone phosphorylation 2/852 12/18722 0.100955731710356 0.290680891131707 MAPK3/FMR1 2 GO:0034370 triglyceride-rich lipoprotein particle remodeling 2/852 12/18722 0.100955731710356 0.290680891131707 LPL/APOE 2 GO:0034372 very-low-density lipoprotein particle remodeling 2/852 12/18722 0.100955731710356 0.290680891131707 LPL/APOE 2 GO:0042117 monocyte activation 2/852 12/18722 0.100955731710356 0.290680891131707 ADAM10/ADAM9 2 GO:0043476 pigment accumulation 2/852 12/18722 0.100955731710356 0.290680891131707 CD63/AP1G1 2 GO:0043482 cellular pigment accumulation 2/852 12/18722 0.100955731710356 0.290680891131707 CD63/AP1G1 2 GO:0045602 negative regulation of endothelial cell differentiation 2/852 12/18722 0.100955731710356 0.290680891131707 ACVRL1/ID1 2 GO:0045605 negative regulation of epidermal cell differentiation 2/852 12/18722 0.100955731710356 0.290680891131707 GRHL2/SRSF6 2 GO:0045683 negative regulation of epidermis development 2/852 12/18722 0.100955731710356 0.290680891131707 GRHL2/SRSF6 2 GO:0045916 negative regulation of complement activation 2/852 12/18722 0.100955731710356 0.290680891131707 SERPING1/CD59 2 GO:0060009 Sertoli cell development 2/852 12/18722 0.100955731710356 0.290680891131707 FLNA/SDC1 2 GO:0060221 retinal rod cell differentiation 2/852 12/18722 0.100955731710356 0.290680891131707 PTN/NAGLU 2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/852 12/18722 0.100955731710356 0.290680891131707 NOG/LRP1 2 GO:0060907 positive regulation of macrophage cytokine production 2/852 12/18722 0.100955731710356 0.290680891131707 HLA-G/SEMA7A 2 GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/852 12/18722 0.100955731710356 0.290680891131707 CITED2/MAPK3 2 GO:0061308 cardiac neural crest cell development involved in heart development 2/852 12/18722 0.100955731710356 0.290680891131707 CITED2/MAPK3 2 GO:0071472 cellular response to salt stress 2/852 12/18722 0.100955731710356 0.290680891131707 ZFP36L1/EFHD1 2 GO:0071635 negative regulation of transforming growth factor beta production 2/852 12/18722 0.100955731710356 0.290680891131707 FN1/FURIN 2 GO:0072711 cellular response to hydroxyurea 2/852 12/18722 0.100955731710356 0.290680891131707 DDI2/FMR1 2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 2/852 12/18722 0.100955731710356 0.290680891131707 CITED2/TMBIM6 2 GO:0099151 regulation of postsynaptic density assembly 2/852 12/18722 0.100955731710356 0.290680891131707 IL1RAP/PTPRS 2 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/852 12/18722 0.100955731710356 0.290680891131707 ENDOG/PINK1 2 GO:1903909 regulation of receptor clustering 2/852 12/18722 0.100955731710356 0.290680891131707 PTN/GSN 2 GO:1905214 regulation of RNA binding 2/852 12/18722 0.100955731710356 0.290680891131707 CARM1/FMR1 2 GO:1905666 regulation of protein localization to endosome 2/852 12/18722 0.100955731710356 0.290680891131707 ANKRD13A/EZR 2 GO:0022600 digestive system process 8/852 104/18722 0.10147187083069 0.291833100509064 F11R/UGCG/SCARB1/LIMA1/LDLR/COPA/EZR/TJP2 8 GO:1901890 positive regulation of cell junction assembly 8/852 104/18722 0.10147187083069 0.291833100509064 SFRP1/IL1RAP/CLDN19/SDC4/SMAD3/EPHB2/TPBG/IQGAP1 8 GO:0046474 glycerophospholipid biosynthetic process 14/852 211/18722 0.101980146082006 0.292943092745706 LPCAT1/MFSD2A/PIGT/IPMK/FABP5/DGKZ/PIK3CB/SLC44A2/CAPN2/INPPL1/PIK3R1/ACSL3/GPAA1/IMPA2 14 GO:0050807 regulation of synapse organization 14/852 211/18722 0.101980146082006 0.292943092745706 SPARC/IL1RAP/PTN/PDLIM5/PTPRS/GPC4/APOE/EPHB2/EFNA1/ADAM10/TIAM1/DAG1/TPBG/ARF4 14 GO:0021537 telencephalon development 16/852 248/18722 0.102098336848839 0.292943092745706 HSD3B1/PTPRS/MFSD2A/EPHB2/FLNA/SRGAP2C/SRGAP2/CTNNB1/RTN4/NCOA1/C12orf57/LRP1/SEMA7A/SUN2/MDK/TACC1 16 GO:0006658 phosphatidylserine metabolic process 3/852 25/18722 0.102905501286391 0.292943092745706 MFSD2A/SERINC3/SERINC2 3 GO:0010560 positive regulation of glycoprotein biosynthetic process 3/852 25/18722 0.102905501286391 0.292943092745706 TCF7L2/CTNNB1/NCSTN 3 GO:0010954 positive regulation of protein processing 3/852 25/18722 0.102905501286391 0.292943092745706 MMP14/MYH9/GSN 3 GO:0010996 response to auditory stimulus 3/852 25/18722 0.102905501286391 0.292943092745706 PTN/SLC1A3/MDK 3 GO:0032878 regulation of establishment or maintenance of cell polarity 3/852 25/18722 0.102905501286391 0.292943092745706 GATA3/PTK2B/GSN 3 GO:0033119 negative regulation of RNA splicing 3/852 25/18722 0.102905501286391 0.292943092745706 PTBP3/SRSF6/TMBIM6 3 GO:0035336 long-chain fatty-acyl-CoA metabolic process 3/852 25/18722 0.102905501286391 0.292943092745706 TECR/ACSL4/ACSL3 3 GO:0036315 cellular response to sterol 3/852 25/18722 0.102905501286391 0.292943092745706 INSIG1/ABCA1/DAG1 3 GO:0046949 fatty-acyl-CoA biosynthetic process 3/852 25/18722 0.102905501286391 0.292943092745706 TECR/ACSL4/ACSL3 3 GO:0048143 astrocyte activation 3/852 25/18722 0.102905501286391 0.292943092745706 GRN/LDLR/LRP1 3 GO:0061436 establishment of skin barrier 3/852 25/18722 0.102905501286391 0.292943092745706 UGCG/LSR/GRHL1 3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3/852 25/18722 0.102905501286391 0.292943092745706 TNFAIP3/SLC15A3/XIAP 3 GO:0072202 cell differentiation involved in metanephros development 3/852 25/18722 0.102905501286391 0.292943092745706 WWTR1/LAMB2/CTNNB1 3 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 3/852 25/18722 0.102905501286391 0.292943092745706 PKP2/GJA5/SRI 3 GO:1901623 regulation of lymphocyte chemotaxis 3/852 25/18722 0.102905501286391 0.292943092745706 PTK2B/ADAM10/ADAM17 3 GO:0051250 negative regulation of lymphocyte activation 11/852 157/18722 0.103176452666558 0.293382534616265 HLA-G/SFRP1/SDC4/ERBB2/INHA/TNFAIP3/PKN1/CBLB/LGALS3/NDFIP1/MDK 11 GO:1990845 adaptive thermogenesis 11/852 157/18722 0.103176452666558 0.293382534616265 DIO2/EPAS1/PLAC8/PLCL2/MFAP2/TLE3/FABP5/RHEB/ID1/ATF4/ADAM17 11 GO:0043550 regulation of lipid kinase activity 6/852 71/18722 0.103764721864118 0.29455603222905 FLT1/TGFB1/PTK2B/DGKZ/PTK2/PIK3R1 6 GO:0045824 negative regulation of innate immune response 6/852 71/18722 0.103764721864118 0.29455603222905 HLA-G/SERPING1/GRN/ISG15/TNFAIP3/STAT2 6 GO:0071230 cellular response to amino acid stimulus 6/852 71/18722 0.103764721864118 0.29455603222905 COL4A1/MMP2/COL6A1/XBP1/SH3BP4/CAPN2 6 GO:0044091 membrane biogenesis 5/852 55/18722 0.104194428789284 0.295609109411763 EPHB2/UGCG/PICALM/CAV2/REEP3 5 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 16/852 249/18722 0.104772604947419 0.297081983493161 TNFSF10/FLNA/HSPB1/TNFAIP3/PLK2/MTDH/CTNNB1/PINK1/BST2/GOLT1B/SLC44A2/NDFIP2/S100A13/NDFIP1/SHISA5/RHOC 16 GO:0000041 transition metal ion transport 8/852 105/18722 0.105728386923647 0.299623294699726 SLC39A6/SLC30A2/SLC39A8/DNM2/ARHGAP1/PGRMC2/ATOX1/SLC39A7 8 GO:0002237 response to molecule of bacterial origin 22/852 363/18722 0.105817765247822 0.299707829202189 SERPINE1/HPGD/SPARC/CSF2RB/TFPI/ADM/PTGES/IL18BP/TSPO/TGFB1/SCARB1/EDNRB/XBP1/TNFAIP3/SASH1/ABCA1/ADAM9/MTDH/MAPK3/CAPN2/IFNAR1/ADAM17 22 GO:0015748 organophosphate ester transport 10/852 140/18722 0.106010860740277 0.300085861701809 APOC1/ABCA7/APOE/MFSD2A/ATP11A/SCARB1/ABCA1/NPC2/SCARB2/LDLR 10 GO:0009914 hormone transport 19/852 306/18722 0.106293498215151 0.300716793994861 SFRP1/TCF7L2/ADM/GATA3/TTR/HMGN3/POMC/CAMK2N1/INHA/SOX4/RAB8B/TIAM1/SNAP23/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 19 GO:0030866 cortical actin cytoskeleton organization 4/852 40/18722 0.107238876860681 0.302710749994283 CALR/NCKAP1/FMNL2/EZR 4 GO:0035329 hippo signaling 4/852 40/18722 0.107238876860681 0.302710749994283 TEAD1/WWTR1/WWC3/AMOTL2 4 GO:0045777 positive regulation of blood pressure 4/852 40/18722 0.107238876860681 0.302710749994283 TAC3/TPM1/F11R/CAMK2N1 4 GO:0070266 necroptotic process 4/852 40/18722 0.107238876860681 0.302710749994283 IPMK/ARHGEF2/PYGL/TP53 4 GO:0071482 cellular response to light stimulus 9/852 123/18722 0.108406421674321 0.305834932896222 PTN/TIMP1/MMP2/OPN3/TP53/DDB1/PIK3R1/FMR1/ATF4 9 GO:0016241 regulation of macroautophagy 10/852 141/18722 0.109738972120607 0.309074564456079 QSOX1/GBA/ATP6V0E1/PINK1/PAFAH1B2/MAPK3/TP53/RHEB/SEC22B/SH3GLB1 10 GO:0035296 regulation of tube diameter 10/852 141/18722 0.109738972120607 0.309074564456079 ADM/DOCK5/PLOD3/ITGA1/APOE/EDNRB/SOD3/BMPR2/GJA5/EXT2 10 GO:0097746 blood vessel diameter maintenance 10/852 141/18722 0.109738972120607 0.309074564456079 ADM/DOCK5/PLOD3/ITGA1/APOE/EDNRB/SOD3/BMPR2/GJA5/EXT2 10 GO:0071887 leukocyte apoptotic process 8/852 106/18722 0.110082187627312 0.309694606108587 CTSL/EFNA1/PKN1/PIK3CB/LGALS3/KDELR1/TP53/ADAM17 8 GO:2000278 regulation of DNA biosynthetic process 8/852 106/18722 0.110082187627312 0.309694606108587 ACVRL1/PTK2B/TNKS2/BMPR2/GRHL2/CTNNB1/MAPK3/TP53 8 GO:0003015 heart process 16/852 251/18722 0.110249040965825 0.309835923871156 TPM1/EPAS1/ADM/WWTR1/TGFB2/KCNJ2/FLNA/GAA/PKP2/DSG2/GJA5/P2RX4/JUP/GSN/EXT2/SRI 16 GO:0022029 telencephalon cell migration 5/852 56/18722 0.110378663123581 0.309835923871156 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0043470 regulation of carbohydrate catabolic process 5/852 56/18722 0.110378663123581 0.309835923871156 PRKAG2/INSR/SCARB2/PPP1CB/TP53 5 GO:0048008 platelet-derived growth factor receptor signaling pathway 5/852 56/18722 0.110378663123581 0.309835923871156 PDGFRL/HIP1/CBLB/PLEKHA1/LRP1 5 GO:0000082 G1/S transition of mitotic cell cycle 14/852 214/18722 0.110864348460973 0.311025789188449 ITGB1/ADAMTS1/SOX4/RPS27L/EIF4EBP1/PLK2/JADE1/CTDSP1/PPP3CA/TP53/BCAT1/WEE1/ADAM17/CCNE1 14 GO:0006909 phagocytosis 19/852 308/18722 0.111252399522619 0.311940572031944 IL2RB/ITGB1/GATA2/ABCA7/SCARB1/CNN2/ABCA1/CALR/DNM2/MYH9/CDC42SE1/LDLR/PTK2/LRP1/CDC42SE2/ARL8B/GULP1/GSN/LMAN2 19 GO:0006006 glucose metabolic process 13/852 196/18722 0.112200518339744 0.314248864109033 IGF2/POMC/GAA/FAM3C/INSR/ATF3/H6PD/FABP5/PPP1CB/INPPL1/TP53/DDB1/ATF4 13 GO:0090276 regulation of peptide hormone secretion 13/852 196/18722 0.112200518339744 0.314248864109033 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/RAB8B/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 13 GO:0097237 cellular response to toxic substance 9/852 124/18722 0.112467274981419 0.314285966359808 PTGES/APOE/GLRX/PRDX4/SOD3/GPX8/PINK1/TXN/GPX4 9 GO:0002092 positive regulation of receptor internalization 3/852 26/18722 0.112588435793112 0.314285966359808 CD63/INSR/FMR1 3 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 3/852 26/18722 0.112588435793112 0.314285966359808 TNFAIP3/SLC15A3/XIAP 3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 3/852 26/18722 0.112588435793112 0.314285966359808 PVR/LAMP1/AP1G1 3 GO:0048668 collateral sprouting 3/852 26/18722 0.112588435793112 0.314285966359808 CRABP2/PTPRS/LRP1 3 GO:0048843 negative regulation of axon extension involved in axon guidance 3/852 26/18722 0.112588435793112 0.314285966359808 SEMA5A/SEMA4C/SEMA7A 3 GO:0035150 regulation of tube size 10/852 142/18722 0.113540814527386 0.314958440711242 ADM/DOCK5/PLOD3/ITGA1/APOE/EDNRB/SOD3/BMPR2/GJA5/EXT2 10 GO:0046467 membrane lipid biosynthetic process 10/852 142/18722 0.113540814527386 0.314958440711242 UGCG/SGMS2/PIGT/PLPP3/PRKD3/SGPP1/GBA/CERS6/B4GALT5/GPAA1 10 GO:0035637 multicellular organismal signaling 11/852 160/18722 0.113693349003531 0.314958440711242 CLDN19/KCNJ2/FLNA/PKP2/GBA/DSG2/GJA5/P2RX4/JUP/FMR1/SRI 11 GO:0050727 regulation of inflammatory response 23/852 386/18722 0.114251545949413 0.314958440711242 SERPINE1/IL6ST/IL1R1/PTGES/GATA3/DNASE1L3/PLA2G7/LPL/SMAD3/APOE/EDNRB/GRN/TNFAIP3/PLK2/GBA/MGLL/LDLR/SEMA7A/GPX4/FURIN/XIAP/NDFIP1/MDK 23 GO:0002637 regulation of immunoglobulin production 6/852 73/18722 0.114584770663859 0.314958440711242 TGFB1/EPHB2/XBP1/PKN1/NDFIP1/TMBIM6 6 GO:0035924 cellular response to vascular endothelial growth factor stimulus 6/852 73/18722 0.114584770663859 0.314958440711242 FLT1/CD63/PGF/HSPB1/PIK3CB/MYO1C 6 GO:0050848 regulation of calcium-mediated signaling 6/852 73/18722 0.114584770663859 0.314958440711242 PTK2B/FHL2/RCAN1/P2RX4/CAMTA1/NFAT5 6 GO:0048634 regulation of muscle organ development 4/852 41/18722 0.114797761861953 0.314958440711242 IGF2/SMAD3/TGFB1/CTNNB1 4 GO:0050856 regulation of T cell receptor signaling pathway 4/852 41/18722 0.114797761861953 0.314958440711242 CBLB/DGKZ/LGALS3/EZR 4 GO:1901385 regulation of voltage-gated calcium channel activity 4/852 41/18722 0.114797761861953 0.314958440711242 RRAD/AHNAK/FMR1/SRI 4 GO:1902116 negative regulation of organelle assembly 4/852 41/18722 0.114797761861953 0.314958440711242 DNM2/PINK1/SEC22B/MAP4 4 GO:0070664 negative regulation of leukocyte proliferation 7/852 90/18722 0.115493335962472 0.314958440711242 HLA-G/SDC4/ERBB2/TNFAIP3/PKN1/CBLB/NDFIP1 7 GO:0001768 establishment of T cell polarity 2/852 13/18722 0.115842971719739 0.314958440711242 MYH9/GSN 2 GO:0001778 plasma membrane repair 2/852 13/18722 0.115842971719739 0.314958440711242 MYH9/ARL8B 2 GO:0001886 endothelial cell morphogenesis 2/852 13/18722 0.115842971719739 0.314958440711242 PLOD3/CLIC4 2 GO:0002638 negative regulation of immunoglobulin production 2/852 13/18722 0.115842971719739 0.314958440711242 NDFIP1/TMBIM6 2 GO:0003222 ventricular trabecula myocardium morphogenesis 2/852 13/18722 0.115842971719739 0.314958440711242 ENG/TGFB2 2 GO:0007183 SMAD protein complex assembly 2/852 13/18722 0.115842971719739 0.314958440711242 SMAD3/TGFB1 2 GO:0008298 intracellular mRNA localization 2/852 13/18722 0.115842971719739 0.314958440711242 MEX3D/ZFP36L1 2 GO:0009650 UV protection 2/852 13/18722 0.115842971719739 0.314958440711242 SCARA3/SDF4 2 GO:0014745 negative regulation of muscle adaptation 2/852 13/18722 0.115842971719739 0.314958440711242 SMAD3/ERRFI1 2 GO:0019336 phenol-containing compound catabolic process 2/852 13/18722 0.115842971719739 0.314958440711242 DIO2/MAOA 2 GO:0021554 optic nerve development 2/852 13/18722 0.115842971719739 0.314958440711242 EPHB2/NAV2 2 GO:0021681 cerebellar granular layer development 2/852 13/18722 0.115842971719739 0.314958440711242 SERPINE2/MDK 2 GO:0021694 cerebellar Purkinje cell layer formation 2/852 13/18722 0.115842971719739 0.314958440711242 HERC1/GBA 2 GO:0030836 positive regulation of actin filament depolymerization 2/852 13/18722 0.115842971719739 0.314958440711242 SEMA5A/DSTN 2 GO:0031272 regulation of pseudopodium assembly 2/852 13/18722 0.115842971719739 0.314958440711242 CDC42EP5/CDC42EP1 2 GO:0031274 positive regulation of pseudopodium assembly 2/852 13/18722 0.115842971719739 0.314958440711242 CDC42EP5/CDC42EP1 2 GO:0032530 regulation of microvillus organization 2/852 13/18722 0.115842971719739 0.314958440711242 KLF5/EZR 2 GO:0033689 negative regulation of osteoblast proliferation 2/852 13/18722 0.115842971719739 0.314958440711242 SFRP1/SMAD3 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/852 13/18722 0.115842971719739 0.314958440711242 TIMP3/ATF3 2 GO:0044090 positive regulation of vacuole organization 2/852 13/18722 0.115842971719739 0.314958440711242 GRN/SH3GLB1 2 GO:0048711 positive regulation of astrocyte differentiation 2/852 13/18722 0.115842971719739 0.314958440711242 SERPINE2/IL6ST 2 GO:0048820 hair follicle maturation 2/852 13/18722 0.115842971719739 0.314958440711242 TGFB2/CTNNB1 2 GO:0051481 negative regulation of cytosolic calcium ion concentration 2/852 13/18722 0.115842971719739 0.314958440711242 SMAD3/LRP1 2 GO:0060100 positive regulation of phagocytosis, engulfment 2/852 13/18722 0.115842971719739 0.314958440711242 GATA2/ABCA7 2 GO:0061469 regulation of type B pancreatic cell proliferation 2/852 13/18722 0.115842971719739 0.314958440711242 SFRP1/ERRFI1 2 GO:0072672 neutrophil extravasation 2/852 13/18722 0.115842971719739 0.314958440711242 IL1R1/MDK 2 GO:0072710 response to hydroxyurea 2/852 13/18722 0.115842971719739 0.314958440711242 DDI2/FMR1 2 GO:0090158 endoplasmic reticulum membrane organization 2/852 13/18722 0.115842971719739 0.314958440711242 TMED2/RTN4 2 GO:0099150 regulation of postsynaptic specialization assembly 2/852 13/18722 0.115842971719739 0.314958440711242 IL1RAP/PTPRS 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/852 13/18722 0.115842971719739 0.314958440711242 XBP1/PIK3R1 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/852 13/18722 0.115842971719739 0.314958440711242 PTN/APOE 2 GO:1903054 negative regulation of extracellular matrix organization 2/852 13/18722 0.115842971719739 0.314958440711242 TGFB1/DPP4 2 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/852 13/18722 0.115842971719739 0.314958440711242 GBA/PINK1 2 GO:1905155 positive regulation of membrane invagination 2/852 13/18722 0.115842971719739 0.314958440711242 GATA2/ABCA7 2 GO:1905907 negative regulation of amyloid fibril formation 2/852 13/18722 0.115842971719739 0.314958440711242 APOE/LDLR 2 GO:0008654 phospholipid biosynthetic process 16/852 253/18722 0.115895694853412 0.314958440711242 HEXB/LPCAT1/MFSD2A/SGMS2/PIGT/IPMK/FABP5/DGKZ/PIK3CB/SLC44A2/CAPN2/INPPL1/PIK3R1/ACSL3/GPAA1/IMPA2 16 GO:0009743 response to carbohydrate 16/852 253/18722 0.115895694853412 0.314958440711242 SPARC/TCF7L2/HMGN3/LPL/CAMK2N1/PTK2B/SOX4/ENDOG/XBP1/TIAM1/ZFP36L1/EGR1/LRP1/PPP3CA/KRT18/SRI 16 GO:0050863 regulation of T cell activation 20/852 329/18722 0.116049914701468 0.315207350616562 IGF2/EBI3/IL6ST/HLA-G/GATA3/SDC4/ERBB2/CD276/EFNB1/SLC7A1/SOX4/XBP1/CBLB/CTNNB1/LGALS3/NDFIP1/MDK/HSPH1/CLPTM1/DPP4 20 GO:0006941 striated muscle contraction 12/852 179/18722 0.116610835401085 0.316559434973554 TPM1/KCNJ2/FLNA/GAA/PKP2/DSG2/GJA5/C12orf57/P2RX4/JUP/GSN/SRI 12 GO:0006611 protein export from nucleus 5/852 57/18722 0.116736402008925 0.316559434973554 TCF7L2/IFI27/TGFB1/CALR/TXN 5 GO:0060042 retina morphogenesis in camera-type eye 5/852 57/18722 0.116736402008925 0.316559434973554 PTN/MFSD2A/MAN2A1/NAGLU/OBSL1 5 GO:0048167 regulation of synaptic plasticity 13/852 198/18722 0.118721364971204 0.321768782929494 SERPINE2/PTN/RASGRF2/PTK2B/APOE/EPHB2/PLK2/EIF4EBP2/YWHAG/NPTN/NCSTN/FMR1/ATF4 13 GO:0046942 carboxylic acid transport 17/852 273/18722 0.119104644493349 0.322633840546301 ITGB1/PTGES/SLCO2A1/PSAP/SLC23A2/SLC7A1/SFXN3/SLC16A3/SLC1A5/SLC16A4/SLC17A5/SLC6A8/SERINC3/P2RX4/SLC1A3/MFSD12/SLC16A1 17 GO:0072503 cellular divalent inorganic cation homeostasis 28/852 486/18722 0.119593282369484 0.323783211493068 HEXB/ADM/SLC39A6/MT1X/GATA2/SMAD3/SLC30A2/SLC39A8/PTK2B/APOE/CCR1/EDNRB/WFS1/CALR/HSP90B1/UBASH3B/CAV2/LRP1/HERPUD1/ACKR2/ITPR2/P2RX4/NPTN/ERO1A/TMBIM6/TMCO1/SLC39A7/SRI 28 GO:0070374 positive regulation of ERK1 and ERK2 cascade 14/852 217/18722 0.12019476374098 0.325236691348576 ABCA7/TGFB1/PTK2B/APOE/CCR1/NOTCH2/CSF1R/TPBG/LRP1/MIF/SEMA7A/MAPK3/NPTN/ATP6AP1 14 GO:0072080 nephron tubule development 7/852 91/18722 0.120519838521747 0.325941078602877 NOG/GATA3/WWTR1/NOTCH2/CTNNB1/LAMA5/MAGED1 7 GO:0051100 negative regulation of binding 11/852 162/18722 0.121032525968561 0.326976222866219 PTPRF/NOG/ADAM15/ACTB/CTSZ/MAPK3/PPP3CA/TMBIM6/SYMPK/ID1/SRI 11 GO:0051494 negative regulation of cytoskeleton organization 11/852 162/18722 0.121032525968561 0.326976222866219 F11R/TMSB10/CAPG/MYADM/LIMA1/PHLDB2/ARHGEF2/SSH2/ARHGEF7/PIK3R1/GSN 11 GO:0000209 protein polyubiquitination 15/852 236/18722 0.12115894875881 0.327142161535993 IFI27/TTC3/TNFAIP3/TNKS2/SASH1/UBE2Q2/CTNNB1/ANKIB1/ANAPC13/RNF144B/TPP2/XIAP/AMFR/UBE2K/UBE2A 15 GO:0031644 regulation of nervous system process 10/852 144/18722 0.121363990849485 0.327520088978797 JAM2/PTK2B/EDNRB/DLGAP4/GBA/MGLL/DAG1/FABP5/SH3GL1/FMR1 10 GO:0000266 mitochondrial fission 4/852 42/18722 0.122583186181814 0.32752415640843 RALBP1/STAT2/INF2/PINK1 4 GO:0006040 amino sugar metabolic process 4/852 42/18722 0.122583186181814 0.32752415640843 SLC35A3/MGAT1/GFPT1/PGM3 4 GO:0014912 negative regulation of smooth muscle cell migration 4/852 42/18722 0.122583186181814 0.32752415640843 TPM1/SERPINE1/IGFBP3/LRP1 4 GO:0016601 Rac protein signal transduction 4/852 42/18722 0.122583186181814 0.32752415640843 NCKAP1/TIAM1/DNM2/PIK3CB 4 GO:0046688 response to copper ion 4/852 42/18722 0.122583186181814 0.32752415640843 AOC1/PAM/MT1X/SOD3 4 GO:0051452 intracellular pH reduction 4/852 42/18722 0.122583186181814 0.32752415640843 GRN/CLIC4/ATP6V0E1/CLN5 4 GO:0001835 blastocyst hatching 3/852 27/18722 0.122601929400652 0.32752415640843 CMTM3/SMIM14/UBE2A 3 GO:0002719 negative regulation of cytokine production involved in immune response 3/852 27/18722 0.122601929400652 0.32752415640843 TGFB1/TGFB2/BST2 3 GO:0003272 endocardial cushion formation 3/852 27/18722 0.122601929400652 0.32752415640843 ENG/NOG/TGFB2 3 GO:0032703 negative regulation of interleukin-2 production 3/852 27/18722 0.122601929400652 0.32752415640843 GATA3/TNFAIP3/EZR 3 GO:0032781 positive regulation of ATPase activity 3/852 27/18722 0.122601929400652 0.32752415640843 TPM1/TOR1AIP2/DNAJC10 3 GO:0035188 hatching 3/852 27/18722 0.122601929400652 0.32752415640843 CMTM3/SMIM14/UBE2A 3 GO:0042403 thyroid hormone metabolic process 3/852 27/18722 0.122601929400652 0.32752415640843 DIO2/GATA3/CTSB 3 GO:0060333 interferon-gamma-mediated signaling pathway 3/852 27/18722 0.122601929400652 0.32752415640843 IFNGR2/JAK1/TP53 3 GO:0070861 regulation of protein exit from endoplasmic reticulum 3/852 27/18722 0.122601929400652 0.32752415640843 OS9/INSIG1/SAR1A 3 GO:0071684 organism emergence from protective structure 3/852 27/18722 0.122601929400652 0.32752415640843 CMTM3/SMIM14/UBE2A 3 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 3/852 27/18722 0.122601929400652 0.32752415640843 CD63/PIK3CB/MYO1C 3 GO:1902883 negative regulation of response to oxidative stress 3/852 27/18722 0.122601929400652 0.32752415640843 PYCR1/PINK1/TXN 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/852 27/18722 0.122601929400652 0.32752415640843 CTNNB1/PINK1/ATF4 3 GO:0007405 neuroblast proliferation 5/852 58/18722 0.123263687881652 0.32859435440061 PTN/PLXNB2/ARHGEF2/CTNNB1/TP53 5 GO:0010043 response to zinc ion 5/852 58/18722 0.123263687881652 0.32859435440061 TSPO/PAM/MT1X/SLC30A2/P2RX4 5 GO:0043506 regulation of JUN kinase activity 5/852 58/18722 0.123263687881652 0.32859435440061 SFRP1/PTK2B/SASH1/TIAM1/HIPK3 5 GO:2000649 regulation of sodium ion transmembrane transporter activity 5/852 58/18722 0.123263687881652 0.32859435440061 FXYD5/GLRX/DNM2/ACTN4/PTPN3 5 GO:0050803 regulation of synapse structure or activity 14/852 218/18722 0.123403415100392 0.328792688300832 SPARC/IL1RAP/PTN/PDLIM5/PTPRS/GPC4/APOE/EPHB2/EFNA1/ADAM10/TIAM1/DAG1/TPBG/ARF4 14 GO:0002366 leukocyte activation involved in immune response 17/852 275/18722 0.124794870398488 0.332324117838937 GATA3/PLCL2/DNASE1L3/GATA2/TGFB1/PTK2B/GRN/XBP1/NOTCH2/SNAP23/LAMP1/LGALS3/S100A13/AP1G1/TP53/NDFIP1/MDK 17 GO:0061351 neural precursor cell proliferation 10/852 145/18722 0.125384344620365 0.333717295861606 PTN/PLXNB2/GATA2/FLNA/ARHGEF2/CTNNB1/CTSZ/TP53/MDK/SPINT1 10 GO:0002791 regulation of peptide secretion 13/852 200/18722 0.125456536273888 0.333732952994968 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/RAB8B/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 13 GO:0006497 protein lipidation 7/852 92/18722 0.125657086107999 0.333913471162386 ZDHHC9/UGCG/PIGT/ABCA1/WIPI1/GBA/GPAA1 7 GO:1903351 cellular response to dopamine 7/852 92/18722 0.125657086107999 0.333913471162386 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0036465 synaptic vesicle recycling 6/852 75/18722 0.125948823180198 0.334159423861854 SYT8/ACTB/CANX/DNM2/PICALM/SH3GL1 6 GO:0043627 response to estrogen 6/852 75/18722 0.125948823180198 0.334159423861854 SFRP1/CITED2/GATA3/KRT19/MMP14/GBA 6 GO:0061333 renal tubule morphogenesis 6/852 75/18722 0.125948823180198 0.334159423861854 COL4A1/NOG/GATA3/CTNNB1/LAMA5/MAGED1 6 GO:0009746 response to hexose 14/852 219/18722 0.126661015200449 0.335871912278113 TCF7L2/HMGN3/LPL/CAMK2N1/PTK2B/SOX4/ENDOG/XBP1/TIAM1/EGR1/LRP1/PPP3CA/KRT18/SRI 14 GO:0046879 hormone secretion 18/852 295/18722 0.127440493770086 0.33776092951282 SFRP1/TCF7L2/ADM/GATA3/HMGN3/POMC/CAMK2N1/INHA/SOX4/RAB8B/TIAM1/SNAP23/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 18 GO:0018958 phenol-containing compound metabolic process 8/852 110/18722 0.128453161732778 0.339425116341622 DIO2/EPAS1/GATA3/MAOA/TGFB2/CTSB/OPN3/MFSD12 8 GO:1904659 glucose transmembrane transport 8/852 110/18722 0.128453161732778 0.339425116341622 PRKAG2/ASPSCR1/INSR/PEA15/FABP5/OPN3/PIK3R1/RTN2 8 GO:0021885 forebrain cell migration 5/852 59/18722 0.129956316430645 0.339425116341622 SRGAP2C/SRGAP2/CTNNB1/RTN4/SUN2 5 GO:0032768 regulation of monooxygenase activity 5/852 59/18722 0.129956316430645 0.339425116341622 PTK2B/APOE/SCARB1/HM13/PIK3CB 5 GO:0043407 negative regulation of MAP kinase activity 5/852 59/18722 0.129956316430645 0.339425116341622 SFRP1/APOE/GBA/PIK3CB/HIPK3 5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 5/852 59/18722 0.129956316430645 0.339425116341622 FLT1/TGFB1/PTK2B/PTK2/PIK3R1 5 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 5/852 59/18722 0.129956316430645 0.339425116341622 SFRP1/SH3BP5/GPRC5A/CBLB/ERRFI1 5 GO:0051353 positive regulation of oxidoreductase activity 5/852 59/18722 0.129956316430645 0.339425116341622 PTK2B/APOE/SCARB1/PIK3CB/RFK 5 GO:0001709 cell fate determination 4/852 43/18722 0.130586874250521 0.339425116341622 GATA3/GATA2/NOTCH2/CTNNB1 4 GO:0014002 astrocyte development 4/852 43/18722 0.130586874250521 0.339425116341622 GRN/LAMB2/LDLR/LRP1 4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4/852 43/18722 0.130586874250521 0.339425116341622 RPS27L/MIF/TP53/SHISA5 4 GO:0060993 kidney morphogenesis 7/852 93/18722 0.130903479924909 0.339425116341622 NOG/GATA3/WWTR1/SOX4/CTNNB1/LAMA5/MAGED1 7 GO:1902807 negative regulation of cell cycle G1/S phase transition 7/852 93/18722 0.130903479924909 0.339425116341622 SOX4/RPS27L/PLK2/JADE1/CTDSP1/TP53/WEE1 7 GO:1903350 response to dopamine 7/852 93/18722 0.130903479924909 0.339425116341622 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0001767 establishment of lymphocyte polarity 2/852 14/18722 0.131238083926246 0.339425116341622 MYH9/GSN 2 GO:0002517 T cell tolerance induction 2/852 14/18722 0.131238083926246 0.339425116341622 HLA-G/CBLB 2 GO:0003188 heart valve formation 2/852 14/18722 0.131238083926246 0.339425116341622 EFNA1/GJA5 2 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2/852 14/18722 0.131238083926246 0.339425116341622 PIK3CB/EZR 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/852 14/18722 0.131238083926246 0.339425116341622 COL27A1/SERPINH1 2 GO:0006596 polyamine biosynthetic process 2/852 14/18722 0.131238083926246 0.339425116341622 SAT1/AMD1 2 GO:0010421 hydrogen peroxide-mediated programmed cell death 2/852 14/18722 0.131238083926246 0.339425116341622 ENDOG/PINK1 2 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 2/852 14/18722 0.131238083926246 0.339425116341622 FBLN1/ACTN4 2 GO:0010838 positive regulation of keratinocyte proliferation 2/852 14/18722 0.131238083926246 0.339425116341622 NOTCH2/MDK 2 GO:0010872 regulation of cholesterol esterification 2/852 14/18722 0.131238083926246 0.339425116341622 APOC1/APOE 2 GO:0014874 response to stimulus involved in regulation of muscle adaptation 2/852 14/18722 0.131238083926246 0.339425116341622 FBXO32/DAG1 2 GO:0031650 regulation of heat generation 2/852 14/18722 0.131238083926246 0.339425116341622 PTGES/EDNRB 2 GO:0034616 response to laminar fluid shear stress 2/852 14/18722 0.131238083926246 0.339425116341622 ABCA1/ADAM9 2 GO:0035563 positive regulation of chromatin binding 2/852 14/18722 0.131238083926246 0.339425116341622 CTBP2/MBD2 2 GO:0035641 locomotory exploration behavior 2/852 14/18722 0.131238083926246 0.339425116341622 APOE/DPP4 2 GO:0042415 norepinephrine metabolic process 2/852 14/18722 0.131238083926246 0.339425116341622 EPAS1/GATA3 2 GO:0043455 regulation of secondary metabolic process 2/852 14/18722 0.131238083926246 0.339425116341622 OPN3/MFSD12 2 GO:0044764 multi-organism cellular process 2/852 14/18722 0.131238083926246 0.339425116341622 CTSL/CAV2 2 GO:0045579 positive regulation of B cell differentiation 2/852 14/18722 0.131238083926246 0.339425116341622 XBP1/MMP14 2 GO:0047484 regulation of response to osmotic stress 2/852 14/18722 0.131238083926246 0.339425116341622 ARHGEF2/EFHD1 2 GO:0048021 regulation of melanin biosynthetic process 2/852 14/18722 0.131238083926246 0.339425116341622 OPN3/MFSD12 2 GO:0051645 Golgi localization 2/852 14/18722 0.131238083926246 0.339425116341622 COPG1/ARCN1 2 GO:0051764 actin crosslink formation 2/852 14/18722 0.131238083926246 0.339425116341622 BAIAP2L1/FLNA 2 GO:0070986 left/right axis specification 2/852 14/18722 0.131238083926246 0.339425116341622 CITED2/NOTCH2 2 GO:0071285 cellular response to lithium ion 2/852 14/18722 0.131238083926246 0.339425116341622 CALR/ADCY7 2 GO:0072498 embryonic skeletal joint development 2/852 14/18722 0.131238083926246 0.339425116341622 NOG/CTNNB1 2 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 2/852 14/18722 0.131238083926246 0.339425116341622 FBLN1/ACTN4 2 GO:1900037 regulation of cellular response to hypoxia 2/852 14/18722 0.131238083926246 0.339425116341622 PINK1/TMBIM6 2 GO:1900376 regulation of secondary metabolite biosynthetic process 2/852 14/18722 0.131238083926246 0.339425116341622 OPN3/MFSD12 2 GO:1901722 regulation of cell proliferation involved in kidney development 2/852 14/18722 0.131238083926246 0.339425116341622 GATA3/EGR1 2 GO:1904294 positive regulation of ERAD pathway 2/852 14/18722 0.131238083926246 0.339425116341622 HERPUD1/TMEM259 2 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/852 14/18722 0.131238083926246 0.339425116341622 GBA/PINK1 2 GO:2001140 positive regulation of phospholipid transport 2/852 14/18722 0.131238083926246 0.339425116341622 ABCA7/APOE 2 GO:0003012 muscle system process 26/852 452/18722 0.131341864191301 0.339519056227436 TPM1/IL6ST/DOCK5/PDLIM5/SMAD3/TPM2/KCNJ2/FLNA/EDNRB/GAA/PKP2/FBXO32/CALD1/TIAM1/DSG2/GJA5/DAG1/C12orf57/CTTN/PPP3CA/SLC6A8/P2RX4/JUP/GSN/ERRFI1/SRI 26 GO:0086001 cardiac muscle cell action potential 6/852 76/18722 0.131828878536567 0.340603052194324 KCNJ2/FLNA/PKP2/DSG2/GJA5/JUP 6 GO:0032388 positive regulation of intracellular transport 13/852 202/18722 0.132404038646606 0.34133338135178 TCF7L2/ERBB2/SMAD3/TGFB1/FLNA/RHOU/PINK1/SAR1A/EZR/JUP/PIK3R1/MYO1C/SH3GLB1 13 GO:0090087 regulation of peptide transport 13/852 202/18722 0.132404038646606 0.34133338135178 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/RAB8B/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 13 GO:0002313 mature B cell differentiation involved in immune response 3/852 28/18722 0.13292537799513 0.34133338135178 PTK2B/XBP1/NOTCH2 3 GO:0002507 tolerance induction 3/852 28/18722 0.13292537799513 0.34133338135178 HLA-G/TNFAIP3/CBLB 3 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 3/852 28/18722 0.13292537799513 0.34133338135178 PRKD3/DGKZ/LRP1 3 GO:0009312 oligosaccharide biosynthetic process 3/852 28/18722 0.13292537799513 0.34133338135178 B4GALT1/MGAT2/ST3GAL6 3 GO:0010464 regulation of mesenchymal cell proliferation 3/852 28/18722 0.13292537799513 0.34133338135178 PTN/CTNNB1/MYCN 3 GO:0010575 positive regulation of vascular endothelial growth factor production 3/852 28/18722 0.13292537799513 0.34133338135178 IL6ST/TGFB1/ATF4 3 GO:0019098 reproductive behavior 3/852 28/18722 0.13292537799513 0.34133338135178 HEXB/NCOA1/MBD2 3 GO:0060765 regulation of androgen receptor signaling pathway 3/852 28/18722 0.13292537799513 0.34133338135178 SFRP1/NCOR2/PKN1 3 GO:0090200 positive regulation of release of cytochrome c from mitochondria 3/852 28/18722 0.13292537799513 0.34133338135178 TNFSF10/PINK1/TP53 3 GO:1903020 positive regulation of glycoprotein metabolic process 3/852 28/18722 0.13292537799513 0.34133338135178 TCF7L2/CTNNB1/NCSTN 3 GO:0071219 cellular response to molecule of bacterial origin 14/852 221/18722 0.133322162175452 0.342177685991356 SERPINE1/TFPI/TSPO/TGFB1/SCARB1/EDNRB/XBP1/TNFAIP3/SASH1/ABCA1/ADAM9/MTDH/MAPK3/CAPN2 14 GO:0022898 regulation of transmembrane transporter activity 17/852 278/18722 0.133624535324217 0.342778943061561 RRAD/ITGB1/FXYD5/RASGRF2/PTK2B/EPHB2/GLRX/ACTB/IFNGR2/DNM2/DAPK1/PINK1/ACTN4/PTPN3/AHNAK/FMR1/SRI 17 GO:0007498 mesoderm development 9/852 129/18722 0.134007316394929 0.343585748046704 NOG/ITGB1/CITED2/SMAD3/BMPR2/ZFP36L1/ETS2/EXT2/CTDNEP1 9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 7/852 94/18722 0.136257308858363 0.348999000246382 CDKN1C/ACTB/CCNG2/TNFAIP3/ADAM17/IPO7/CCNE1 7 GO:0048704 embryonic skeletal system morphogenesis 7/852 94/18722 0.136257308858363 0.348999000246382 NOG/SMAD3/MMP14/GRHL2/CTNNB1/MYCN/RDH10 7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 5/852 60/18722 0.136809853904892 0.350236009513387 MBNL2/RBFOX2/SRSF6/FMR1/DDX17 5 GO:0060047 heart contraction 15/852 241/18722 0.13703831738752 0.350642527407924 TPM1/EPAS1/ADM/TGFB2/KCNJ2/FLNA/GAA/PKP2/DSG2/GJA5/P2RX4/JUP/GSN/EXT2/SRI 15 GO:0031016 pancreas development 6/852 77/18722 0.137837446538235 0.352421250605769 IGF2/TCF7L2/SOX4/WFS1/CTNNB1/RHEB 6 GO:0043484 regulation of RNA splicing 10/852 148/18722 0.137873523235199 0.352421250605769 MBNL2/PTBP3/HNRNPH1/RBFOX2/SRSF6/TMBIM6/PIK3R1/AHNAK/FMR1/DDX17 10 GO:0002526 acute inflammatory response 8/852 112/18722 0.138197712157542 0.352640870031639 FN1/IL6ST/PTGES/GATA3/PRCP/DNASE1L3/EDNRB/B4GALT1 8 GO:0043467 regulation of generation of precursor metabolites and energy 9/852 130/18722 0.13855712863699 0.352640870031639 IGF2/PRKAG2/POMC/INSR/PINK1/OPN3/PPP1CB/TP53/IFNAR1 9 GO:1904062 regulation of cation transmembrane transport 21/852 357/18722 0.138650740665331 0.352640870031639 RRAD/ITGB1/FXYD5/RASGRF2/PTK2B/EPHB2/KCNJ2/SESTD1/FLNA/GLRX/CD63/IFNGR2/DNM2/UBASH3B/DAPK1/PINK1/ACTN4/PTPN3/AHNAK/FMR1/SRI 21 GO:0002066 columnar/cuboidal epithelial cell development 4/852 44/18722 0.138800231180743 0.352640870031639 IL6ST/KLF5/RHEB/YIPF6 4 GO:0005978 glycogen biosynthetic process 4/852 44/18722 0.138800231180743 0.352640870031639 IGF2/PHKG1/INSR/PPP1CB 4 GO:0009250 glucan biosynthetic process 4/852 44/18722 0.138800231180743 0.352640870031639 IGF2/PHKG1/INSR/PPP1CB 4 GO:0030521 androgen receptor signaling pathway 4/852 44/18722 0.138800231180743 0.352640870031639 SFRP1/NCOR2/PKN1/DDX17 4 GO:0042269 regulation of natural killer cell mediated cytotoxicity 4/852 44/18722 0.138800231180743 0.352640870031639 HLA-G/PVR/LAMP1/AP1G1 4 GO:0050999 regulation of nitric-oxide synthase activity 4/852 44/18722 0.138800231180743 0.352640870031639 PTK2B/APOE/SCARB1/PIK3CB 4 GO:0089718 amino acid import across plasma membrane 4/852 44/18722 0.138800231180743 0.352640870031639 ITGB1/SLC7A1/SLC1A5/SLC1A3 4 GO:0097178 ruffle assembly 4/852 44/18722 0.138800231180743 0.352640870031639 AIF1L/EVL/INPPL1/EPS8L2 4 GO:1903214 regulation of protein targeting to mitochondrion 4/852 44/18722 0.138800231180743 0.352640870031639 RHOU/LMAN1/PINK1/SH3GLB1 4 GO:1903320 regulation of protein modification by small protein conjugation or removal 15/852 242/18722 0.140348244018433 0.356393901183033 EPAS1/TSPO/SOX4/ISG15/TNFAIP3/WFS1/SASH1/CBLB/CTNNB1/PINK1/EGR1/HERPUD1/NDFIP2/XIAP/NDFIP1 15 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 11/852 167/18722 0.140505888788857 0.356614290607321 ITGB1/PLXNB2/PVR/FAT2/ESAM/PALLD/FAT1/DSG2/BSG/NPTN/OBSL1 11 GO:0002532 production of molecular mediator involved in inflammatory response 7/852 95/18722 0.141716753555995 0.359325148940716 SERPINE1/IL1R2/GRN/PLD3/SNAP23/ADCY7/CHID1 7 GO:0008593 regulation of Notch signaling pathway 7/852 95/18722 0.141716753555995 0.359325148940716 IL6ST/GATA2/TGFB2/MMP14/ADAM10/TSPAN14/EPN2 7 GO:1905039 carboxylic acid transmembrane transport 10/852 149/18722 0.142177070756568 0.360224221505154 ITGB1/SLC23A2/SLC7A1/SFXN3/SLC16A3/SLC1A5/SLC38A10/SLC1A3/MFSD12/SLC16A1 10 GO:0120032 regulation of plasma membrane bounded cell projection assembly 12/852 186/18722 0.1422144899922 0.360224221505154 CDC42EP5/SRGAP2C/MYO10/NCKAP1/DNM2/CDC42EP1/EVL/KLF5/PIK3R1/FMR1/EPS8L2/MAP4 12 GO:0007249 I-kappaB kinase/NF-kappaB signaling 17/852 281/18722 0.14280389508475 0.360852592103809 TNFSF10/FLNA/PRDX4/HSPB1/TNFAIP3/PLK2/MTDH/CTNNB1/PINK1/BST2/GOLT1B/SLC44A2/NDFIP2/S100A13/NDFIP1/SHISA5/RHOC 17 GO:0019079 viral genome replication 9/852 131/18722 0.143185463524973 0.360852592103809 IFI27/ISG15/PPIB/CTBP2/PABPC1/BST2/DDB1/FMR1/PCBP2 9 GO:0044106 cellular amine metabolic process 8/852 113/18722 0.14320556770865 0.360852592103809 AOC1/EPAS1/GATA3/MAOA/TGFB2/GDPD3/SAT1/AMD1 8 GO:0005979 regulation of glycogen biosynthetic process 3/852 29/18722 0.14353802690082 0.360852592103809 IGF2/INSR/PPP1CB 3 GO:0010592 positive regulation of lamellipodium assembly 3/852 29/18722 0.14353802690082 0.360852592103809 NCKAP1/DNM2/PIK3R1 3 GO:0010962 regulation of glucan biosynthetic process 3/852 29/18722 0.14353802690082 0.360852592103809 IGF2/INSR/PPP1CB 3 GO:0015701 bicarbonate transport 3/852 29/18722 0.14353802690082 0.360852592103809 SLC4A7/SLC39A8/CYB5R1 3 GO:0019433 triglyceride catabolic process 3/852 29/18722 0.14353802690082 0.360852592103809 LPL/MGLL/LIPG 3 GO:0033028 myeloid cell apoptotic process 3/852 29/18722 0.14353802690082 0.360852592103809 CTSL/PIK3CB/ADAM17 3 GO:0034311 diol metabolic process 3/852 29/18722 0.14353802690082 0.360852592103809 PLPP3/SGPP1/GBA 3 GO:0040018 positive regulation of multicellular organism growth 3/852 29/18722 0.14353802690082 0.360852592103809 IGF2/PPIB/EZR 3 GO:0071549 cellular response to dexamethasone stimulus 3/852 29/18722 0.14353802690082 0.360852592103809 SMYD3/FBXO32/ERRFI1 3 GO:0090025 regulation of monocyte chemotaxis 3/852 29/18722 0.14353802690082 0.360852592103809 SERPINE1/PLA2G7/CCR1 3 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/852 29/18722 0.14353802690082 0.360852592103809 P4HB/HSPB1/PINK1 3 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 3/852 29/18722 0.14353802690082 0.360852592103809 CD63/PIK3CB/MYO1C 3 GO:0060997 dendritic spine morphogenesis 5/852 61/18722 0.143819654383923 0.361221144783907 PDLIM5/EPHB2/EFNA1/ADAM10/TIAM1 5 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 6/852 78/18722 0.143971710001295 0.361221144783907 EGLN3/SMAD3/HIP1/RPS27L/DAP/CTSH 6 GO:0032024 positive regulation of insulin secretion 6/852 78/18722 0.143971710001295 0.361221144783907 TCF7L2/CAMK2N1/SOX4/ACSL4/LRP1/SRI 6 GO:0035050 embryonic heart tube development 6/852 78/18722 0.143971710001295 0.361221144783907 ENG/CITED2/SMAD3/NOTCH2/TMED2/CTNNB1 6 GO:1903825 organic acid transmembrane transport 10/852 150/18722 0.146549633064413 0.361237665472016 ITGB1/SLC23A2/SLC7A1/SFXN3/SLC16A3/SLC1A5/SLC38A10/SLC1A3/MFSD12/SLC16A1 10 GO:0008016 regulation of heart contraction 13/852 206/18722 0.146925895559429 0.361237665472016 TPM1/EPAS1/ADM/TGFB2/KCNJ2/FLNA/GAA/PKP2/DSG2/GJA5/P2RX4/JUP/SRI 13 GO:0017038 protein import 13/852 206/18722 0.146925895559429 0.361237665472016 SMAD3/TGFB1/APOE/FLNA/RAB8B/CBLB/PKIG/PPP3CA/TP53/JUP/PIK3R1/LAMP2/IPO7 13 GO:0006098 pentose-phosphate shunt 2/852 15/18722 0.14706415090283 0.361237665472016 H6PD/TP53 2 GO:0006704 glucocorticoid biosynthetic process 2/852 15/18722 0.14706415090283 0.361237665472016 CYP11A1/H6PD 2 GO:0010820 positive regulation of T cell chemotaxis 2/852 15/18722 0.14706415090283 0.361237665472016 ADAM10/ADAM17 2 GO:0010832 negative regulation of myotube differentiation 2/852 15/18722 0.14706415090283 0.361237665472016 XBP1/HDAC5 2 GO:0010940 positive regulation of necrotic cell death 2/852 15/18722 0.14706415090283 0.361237665472016 TSPO/TP53 2 GO:0018146 keratan sulfate biosynthetic process 2/852 15/18722 0.14706415090283 0.361237665472016 B3GNT7/ST3GAL6 2 GO:0032310 prostaglandin secretion 2/852 15/18722 0.14706415090283 0.361237665472016 PTGES/P2RX4 2 GO:0032354 response to follicle-stimulating hormone 2/852 15/18722 0.14706415090283 0.361237665472016 PAPPA/TGFBR3 2 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 2/852 15/18722 0.14706415090283 0.361237665472016 CITED2/FABP5 2 GO:0035627 ceramide transport 2/852 15/18722 0.14706415090283 0.361237665472016 PSAP/SGPP1 2 GO:0043508 negative regulation of JUN kinase activity 2/852 15/18722 0.14706415090283 0.361237665472016 SFRP1/HIPK3 2 GO:0045176 apical protein localization 2/852 15/18722 0.14706415090283 0.361237665472016 ACTB/ARF4 2 GO:0045475 locomotor rhythm 2/852 15/18722 0.14706415090283 0.361237665472016 NAGLU/EGR1 2 GO:0045725 positive regulation of glycogen biosynthetic process 2/852 15/18722 0.14706415090283 0.361237665472016 IGF2/INSR 2 GO:0048569 post-embryonic animal organ development 2/852 15/18722 0.14706415090283 0.361237665472016 FBN1/MFAP2 2 GO:0050746 regulation of lipoprotein metabolic process 2/852 15/18722 0.14706415090283 0.361237665472016 GBA/LIPG 2 GO:0051127 positive regulation of actin nucleation 2/852 15/18722 0.14706415090283 0.361237665472016 NCKAP1/GSN 2 GO:0051938 L-glutamate import 2/852 15/18722 0.14706415090283 0.361237665472016 ITGB1/SLC1A3 2 GO:0060099 regulation of phagocytosis, engulfment 2/852 15/18722 0.14706415090283 0.361237665472016 GATA2/ABCA7 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/852 15/18722 0.14706415090283 0.361237665472016 SFRP1/NCOR2 2 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 2/852 15/18722 0.14706415090283 0.361237665472016 FHL2/RCAN1 2 GO:0072224 metanephric glomerulus development 2/852 15/18722 0.14706415090283 0.361237665472016 LAMB2/EGR1 2 GO:0097468 programmed cell death in response to reactive oxygen species 2/852 15/18722 0.14706415090283 0.361237665472016 ENDOG/PINK1 2 GO:0098712 L-glutamate import across plasma membrane 2/852 15/18722 0.14706415090283 0.361237665472016 ITGB1/SLC1A3 2 GO:0098760 response to interleukin-7 2/852 15/18722 0.14706415090283 0.361237665472016 P4HB/PDIA3 2 GO:0098761 cellular response to interleukin-7 2/852 15/18722 0.14706415090283 0.361237665472016 P4HB/PDIA3 2 GO:0106057 negative regulation of calcineurin-mediated signaling 2/852 15/18722 0.14706415090283 0.361237665472016 FHL2/RCAN1 2 GO:0150011 regulation of neuron projection arborization 2/852 15/18722 0.14706415090283 0.361237665472016 MFSD2A/MACF1 2 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/852 15/18722 0.14706415090283 0.361237665472016 PABPC1/ZFP36L1 2 GO:1901741 positive regulation of myoblast fusion 2/852 15/18722 0.14706415090283 0.361237665472016 GDF15/CAPN2 2 GO:1901841 regulation of high voltage-gated calcium channel activity 2/852 15/18722 0.14706415090283 0.361237665472016 RRAD/SRI 2 GO:1902018 negative regulation of cilium assembly 2/852 15/18722 0.14706415090283 0.361237665472016 DNM2/MAP4 2 GO:1902902 negative regulation of autophagosome assembly 2/852 15/18722 0.14706415090283 0.361237665472016 PINK1/SEC22B 2 GO:1903543 positive regulation of exosomal secretion 2/852 15/18722 0.14706415090283 0.361237665472016 SDC4/SDC1 2 GO:1903727 positive regulation of phospholipid metabolic process 2/852 15/18722 0.14706415090283 0.361237665472016 CAPN2/ACSL3 2 GO:1904889 regulation of excitatory synapse assembly 2/852 15/18722 0.14706415090283 0.361237665472016 IL1RAP/PTPRS 2 GO:2001138 regulation of phospholipid transport 2/852 15/18722 0.14706415090283 0.361237665472016 ABCA7/APOE 2 GO:0030850 prostate gland development 4/852 45/18722 0.147214385799711 0.361237665472016 NOG/SFRP1/PSAP/CTNNB1 4 GO:0042551 neuron maturation 4/852 45/18722 0.147214385799711 0.361237665472016 NTN4/EDNRB/CLN5/B4GALT5 4 GO:0046189 phenol-containing compound biosynthetic process 4/852 45/18722 0.147214385799711 0.361237665472016 GATA3/TGFB2/OPN3/MFSD12 4 GO:0048538 thymus development 4/852 45/18722 0.147214385799711 0.361237665472016 CITED2/GATA3/CTNNB1/MAPK3 4 GO:0051180 vitamin transport 4/852 45/18722 0.147214385799711 0.361237665472016 SLC23A2/SCARB1/CD320/LMBRD1 4 GO:0002718 regulation of cytokine production involved in immune response 7/852 96/18722 0.147279890631547 0.361237665472016 HLA-G/IL1R1/GATA3/TGFB1/TGFB2/BST2/SEMA7A 7 GO:0007569 cell aging 9/852 132/18722 0.147891308636033 0.362560621707332 SERPINE1/HLA-G/CITED2/NUAK1/PLK2/CALR/YPEL3/MIF/TP53 9 GO:0008645 hexose transmembrane transport 8/852 114/18722 0.148302003388886 0.363213617059009 PRKAG2/ASPSCR1/INSR/PEA15/FABP5/OPN3/PIK3R1/RTN2 8 GO:1901800 positive regulation of proteasomal protein catabolic process 8/852 114/18722 0.148302003388886 0.363213617059009 PLK2/GBA/ANKIB1/HERPUD1/RNF144B/CSNK1A1/FMR1/TMEM259 8 GO:0006937 regulation of muscle contraction 11/852 169/18722 0.1487348589548 0.364096568637894 TPM1/DOCK5/KCNJ2/PKP2/DSG2/GJA5/C12orf57/CTTN/P2RX4/JUP/SRI 11 GO:0006575 cellular modified amino acid metabolic process 12/852 188/18722 0.150042723743981 0.366941218952118 DIO2/GATA3/PLOD3/PLOD2/PIPOX/MFSD2A/CTSB/PCYOX1/GPX4/SLC6A8/SERINC3/SERINC2 12 GO:0060491 regulation of cell projection assembly 12/852 188/18722 0.150042723743981 0.366941218952118 CDC42EP5/SRGAP2C/MYO10/NCKAP1/DNM2/CDC42EP1/EVL/KLF5/PIK3R1/FMR1/EPS8L2/MAP4 12 GO:0032272 negative regulation of protein polymerization 6/852 79/18722 0.150228711737512 0.367217632916415 TMSB10/CAPG/MYADM/SSH2/ARHGEF7/GSN 6 GO:0098656 anion transmembrane transport 15/852 245/18722 0.150541620269314 0.367803871269638 ITGB1/SLC4A7/SLC12A8/SLC39A8/SLC35A3/SLC23A2/SLC7A1/SFXN3/SLC16A3/SLC1A5/PCYOX1/SLC6A8/SLC1A3/MFSD12/SLC16A1 15 GO:0032731 positive regulation of interleukin-1 beta production 5/852 62/18722 0.150980876944664 0.368340646467521 LPL/SMAD3/HSPB1/EGR1/NLRP2 5 GO:0060675 ureteric bud morphogenesis 5/852 62/18722 0.150980876944664 0.368340646467521 NOG/GATA3/CTNNB1/LAMA5/MAGED1 5 GO:0070265 necrotic cell death 5/852 62/18722 0.150980876944664 0.368340646467521 TSPO/IPMK/ARHGEF2/PYGL/TP53 5 GO:0043255 regulation of carbohydrate biosynthetic process 7/852 97/18722 0.152944696979113 0.372770295349092 IGF2/TGFB1/PTK2B/FAM3C/INSR/PPP1CB/DDB1 7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 7/852 97/18722 0.152944696979113 0.372770295349092 SERPINE1/TCF7L2/TNFAIP3/ARHGEF2/PEA15/LGALS3/CTTN 7 GO:0042471 ear morphogenesis 8/852 115/18722 0.153485570054166 0.373907489875419 NOG/GATA3/GATA2/EPHB2/INSIG1/NAGLU/MAPK3/MYO6 8 GO:0003299 muscle hypertrophy in response to stress 3/852 30/18722 0.154419087755686 0.374369589920216 SMAD3/PPP3CA/ERRFI1 3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/852 30/18722 0.154419087755686 0.374369589920216 PRKAG2/TGFB1/UBE2K 3 GO:0014887 cardiac muscle adaptation 3/852 30/18722 0.154419087755686 0.374369589920216 SMAD3/PPP3CA/ERRFI1 3 GO:0014898 cardiac muscle hypertrophy in response to stress 3/852 30/18722 0.154419087755686 0.374369589920216 SMAD3/PPP3CA/ERRFI1 3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 3/852 30/18722 0.154419087755686 0.374369589920216 CTSL/DNM2/CTSF 3 GO:0044030 regulation of DNA methylation 3/852 30/18722 0.154419087755686 0.374369589920216 GRHL2/MBD2/MBD3 3 GO:0045940 positive regulation of steroid metabolic process 3/852 30/18722 0.154419087755686 0.374369589920216 ADM/APOC1/APOE 3 GO:0046825 regulation of protein export from nucleus 3/852 30/18722 0.154419087755686 0.374369589920216 TCF7L2/IFI27/TXN 3 GO:0060292 long-term synaptic depression 3/852 30/18722 0.154419087755686 0.374369589920216 PTK2B/PLK2/FMR1 3 GO:0099068 postsynapse assembly 3/852 30/18722 0.154419087755686 0.374369589920216 IL1RAP/PTPRS/EPHB2 3 GO:1901215 negative regulation of neuron death 13/852 208/18722 0.154494118902719 0.374371160537979 SLC23A2/PTK2B/APOE/GRN/WFS1/CTNNB1/GBA/PINK1/ERBB3/LRP1/MDK/ATF4/TMEM259 13 GO:0098754 detoxification 10/852 152/18722 0.155498525485259 0.376316327936897 PTGES/MT1X/APOE/RALBP1/GLRX/PRDX4/SOD3/GPX8/TXN/GPX4 10 GO:0010830 regulation of myotube differentiation 4/852 46/18722 0.155820231953207 0.376316327936897 ATP11A/XBP1/MMP14/HDAC5 4 GO:0031648 protein destabilization 4/852 46/18722 0.155820231953207 0.376316327936897 SERF2/RNF139/CTSH/GSN 4 GO:0043462 regulation of ATPase activity 4/852 46/18722 0.155820231953207 0.376316327936897 TPM1/TPM2/TOR1AIP2/DNAJC10 4 GO:0043616 keratinocyte proliferation 4/852 46/18722 0.155820231953207 0.376316327936897 NOTCH2/ZFP36L1/SRSF6/MDK 4 GO:0048701 embryonic cranial skeleton morphogenesis 4/852 46/18722 0.155820231953207 0.376316327936897 SMAD3/MMP14/GRHL2/RDH10 4 GO:0050919 negative chemotaxis 4/852 46/18722 0.155820231953207 0.376316327936897 SEMA5A/SEMA4C/SEMA7A/DPP4 4 GO:0048145 regulation of fibroblast proliferation 6/852 80/18722 0.15660536273184 0.377849851691922 FN1/SFRP1/FOSL2/CTNNB1/MIF/TP53 6 GO:0071229 cellular response to acid chemical 6/852 80/18722 0.15660536273184 0.377849851691922 COL4A1/MMP2/COL6A1/XBP1/SH3BP4/CAPN2 6 GO:0048469 cell maturation 11/852 171/18722 0.157207744973131 0.379121504767497 EPAS1/GATA3/GATA2/NTN4/PTK2B/EDNRB/PTBP3/CTNNB1/GBA/CLN5/B4GALT5 11 GO:0031098 stress-activated protein kinase signaling cascade 15/852 247/18722 0.157553841930304 0.379774179327213 SFRP1/SMAD3/TGFB2/PTK2B/CDC42EP5/SEMA4C/SASH1/PINK1/ZFP36L1/MAPK3/RNF13/HIPK3/EZR/SH2D3A/EMC10 15 GO:0009755 hormone-mediated signaling pathway 12/852 190/18722 0.158091807757867 0.380120189580424 SFRP1/PRCP/NCOR2/PKN1/CALR/CARM1/NCOA1/PAQR7/PGRMC2/RBFOX2/RXRA/DDX17 12 GO:0023061 signal release 26/852 463/18722 0.158228359392327 0.380120189580424 SFRP1/TCF7L2/ADM/PTGES/GATA3/HMGN3/SYT8/POMC/CAMK2N1/INHA/SOX4/STXBP5/RAB8B/ABCA1/TIAM1/SNAP23/CTBP2/PINK1/ACSL4/LRP1/PPP3CA/P2RX4/FMR1/SLC16A1/SRI/DPP4 26 GO:0001947 heart looping 5/852 63/18722 0.158288502663903 0.380120189580424 ENG/CITED2/SMAD3/NOTCH2/TMED2 5 GO:0072171 mesonephric tubule morphogenesis 5/852 63/18722 0.158288502663903 0.380120189580424 NOG/GATA3/CTNNB1/LAMA5/MAGED1 5 GO:2000242 negative regulation of reproductive process 5/852 63/18722 0.158288502663903 0.380120189580424 TIMP1/ARHGDIB/PRDX4/CALR/MYH9 5 GO:0002367 cytokine production involved in immune response 7/852 98/18722 0.158709054182678 0.380120189580424 HLA-G/IL1R1/GATA3/TGFB1/TGFB2/BST2/SEMA7A 7 GO:0003333 amino acid transmembrane transport 7/852 98/18722 0.158709054182678 0.380120189580424 ITGB1/SLC7A1/SFXN3/SLC1A5/SLC38A10/SLC1A3/MFSD12 7 GO:0043473 pigmentation 7/852 98/18722 0.158709054182678 0.380120189580424 POMC/CD63/EDNRB/ATRN/AP1G1/ARCN1/MFSD12 7 GO:0043502 regulation of muscle adaptation 7/852 98/18722 0.158709054182678 0.380120189580424 IL6ST/SMAD3/FBXO32/DAG1/PPP3CA/P2RX4/ERRFI1 7 GO:0061337 cardiac conduction 7/852 98/18722 0.158709054182678 0.380120189580424 KCNJ2/FLNA/PKP2/DSG2/GJA5/JUP/SRI 7 GO:0070301 cellular response to hydrogen peroxide 7/852 98/18722 0.158709054182678 0.380120189580424 IL18BP/PYCR1/ENDOG/TNFAIP3/PINK1/PLEKHA1/TXN 7 GO:0008286 insulin receptor signaling pathway 8/852 116/18722 0.158754746373545 0.380120189580424 IGF2/BAIAP2L1/INSR/EIF4EBP2/AP3S1/CAV2/BCAR3/PIK3R1 8 GO:0043200 response to amino acid 8/852 116/18722 0.158754746373545 0.380120189580424 COL4A1/PTN/MMP2/COL6A1/XBP1/SH3BP4/CAPN2/TMBIM6 8 GO:1990748 cellular detoxification 8/852 116/18722 0.158754746373545 0.380120189580424 PTGES/APOE/GLRX/PRDX4/SOD3/GPX8/TXN/GPX4 8 GO:0120254 olefinic compound metabolic process 10/852 153/18722 0.160073104743549 0.382983545042698 ADM/TTR/CYP11A1/DHRS3/H6PD/MGLL/EGR1/MAPK3/GPX4/RDH10 10 GO:0032412 regulation of ion transmembrane transporter activity 16/852 267/18722 0.160102797291841 0.382983545042698 RRAD/ITGB1/FXYD5/RASGRF2/PTK2B/EPHB2/GLRX/IFNGR2/DNM2/DAPK1/PINK1/ACTN4/PTPN3/AHNAK/FMR1/SRI 16 GO:0033002 muscle cell proliferation 15/852 248/18722 0.16112393882396 0.384842250303099 TPM1/HPGD/IGFBP3/NOG/TCF7L2/CITED2/ADAMTS1/MMP2/TGFB1/TGFB2/APOE/TNFAIP3/BMPR2/CTNNB1/TGFBR3 15 GO:0045786 negative regulation of cell cycle 22/852 385/18722 0.16201556484079 0.384842250303099 HPGD/TIMP2/HLA-G/GATA3/SMAD3/CAMK2N1/TGFB1/INHA/SOX4/CDKN1C/RPS27L/TNFAIP3/PLK2/CTNNB1/ZFP36L1/JADE1/CTDSP1/TP53/PTPN3/TP53I13/WEE1/IPO7 22 GO:0000422 autophagy of mitochondrion 6/852 81/18722 0.163098450374514 0.384842250303099 TSPO/WIPI1/GBA/PINK1/CTTN/TP53 6 GO:0048144 fibroblast proliferation 6/852 81/18722 0.163098450374514 0.384842250303099 FN1/SFRP1/FOSL2/CTNNB1/MIF/TP53 6 GO:0061726 mitochondrion disassembly 6/852 81/18722 0.163098450374514 0.384842250303099 TSPO/WIPI1/GBA/PINK1/CTTN/TP53 6 GO:0071260 cellular response to mechanical stimulus 6/852 81/18722 0.163098450374514 0.384842250303099 ENG/F11R/KCNJ2/CNN2/DAG1/MAPK3 6 GO:0002693 positive regulation of cellular extravasation 2/852 16/18722 0.163250189627879 0.384842250303099 IL1R1/MDK 2 GO:0002921 negative regulation of humoral immune response 2/852 16/18722 0.163250189627879 0.384842250303099 SERPING1/CD59 2 GO:0006740 NADPH regeneration 2/852 16/18722 0.163250189627879 0.384842250303099 H6PD/TP53 2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2/852 16/18722 0.163250189627879 0.384842250303099 RPS27L/TP53 2 GO:0007635 chemosensory behavior 2/852 16/18722 0.163250189627879 0.384842250303099 WFS1/TPBG 2 GO:0009415 response to water 2/852 16/18722 0.163250189627879 0.384842250303099 CD9/KRT8 2 GO:0010649 regulation of cell communication by electrical coupling 2/852 16/18722 0.163250189627879 0.384842250303099 GJA5/SRI 2 GO:0010819 regulation of T cell chemotaxis 2/852 16/18722 0.163250189627879 0.384842250303099 ADAM10/ADAM17 2 GO:0014819 regulation of skeletal muscle contraction 2/852 16/18722 0.163250189627879 0.384842250303099 KCNJ2/C12orf57 2 GO:0034374 low-density lipoprotein particle remodeling 2/852 16/18722 0.163250189627879 0.384842250303099 PLA2G7/APOE 2 GO:0035751 regulation of lysosomal lumen pH 2/852 16/18722 0.163250189627879 0.384842250303099 GRN/CLN5 2 GO:0045779 negative regulation of bone resorption 2/852 16/18722 0.163250189627879 0.384842250303099 TNFAIP3/UBASH3B 2 GO:0051238 sequestering of metal ion 2/852 16/18722 0.163250189627879 0.384842250303099 SLC30A2/SRI 2 GO:0051969 regulation of transmission of nerve impulse 2/852 16/18722 0.163250189627879 0.384842250303099 GBA/FMR1 2 GO:0055089 fatty acid homeostasis 2/852 16/18722 0.163250189627879 0.384842250303099 APOE/XBP1 2 GO:0061684 chaperone-mediated autophagy 2/852 16/18722 0.163250189627879 0.384842250303099 CTSA/LAMP2 2 GO:0070242 thymocyte apoptotic process 2/852 16/18722 0.163250189627879 0.384842250303099 EFNA1/TP53 2 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 2/852 16/18722 0.163250189627879 0.384842250303099 TNFAIP3/SLC15A3 2 GO:0090520 sphingolipid mediated signaling pathway 2/852 16/18722 0.163250189627879 0.384842250303099 PIK3CB/EZR 2 GO:1904683 regulation of metalloendopeptidase activity 2/852 16/18722 0.163250189627879 0.384842250303099 TIMP3/PICALM 2 GO:1904948 midbrain dopaminergic neuron differentiation 2/852 16/18722 0.163250189627879 0.384842250303099 SFRP1/CTNNB1 2 GO:1905153 regulation of membrane invagination 2/852 16/18722 0.163250189627879 0.384842250303099 GATA2/ABCA7 2 GO:1905874 regulation of postsynaptic density organization 2/852 16/18722 0.163250189627879 0.384842250303099 IL1RAP/PTPRS 2 GO:1905906 regulation of amyloid fibril formation 2/852 16/18722 0.163250189627879 0.384842250303099 APOE/LDLR 2 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/852 16/18722 0.163250189627879 0.384842250303099 SMAD3/GSN 2 GO:0003300 cardiac muscle hypertrophy 7/852 99/18722 0.164570753006762 0.385516249202488 IL6ST/PDLIM5/SMAD3/TIAM1/PPP3CA/P2RX4/ERRFI1 7 GO:0007595 lactation 4/852 47/18722 0.164608468018308 0.385516249202488 PAM/XBP1/NCOR2/NCOA1 4 GO:0010712 regulation of collagen metabolic process 4/852 47/18722 0.164608468018308 0.385516249202488 ENG/ITGB1/TGFB1/ERRFI1 4 GO:0019884 antigen processing and presentation of exogenous antigen 4/852 47/18722 0.164608468018308 0.385516249202488 CTSL/TAP1/DNM2/CTSF 4 GO:0031641 regulation of myelination 4/852 47/18722 0.164608468018308 0.385516249202488 PTN/JAM2/CTNNB1/DAG1 4 GO:0043114 regulation of vascular permeability 4/852 47/18722 0.164608468018308 0.385516249202488 ADM/TGFB1/APOE/TJP2 4 GO:0045332 phospholipid translocation 4/852 47/18722 0.164608468018308 0.385516249202488 ABCA7/MFSD2A/ATP11A/ABCA1 4 GO:0045646 regulation of erythrocyte differentiation 4/852 47/18722 0.164608468018308 0.385516249202488 GATA2/ISG15/ZFP36L1/RBFOX2 4 GO:0045747 positive regulation of Notch signaling pathway 4/852 47/18722 0.164608468018308 0.385516249202488 IL6ST/TGFB2/TSPAN14/EPN2 4 GO:0051489 regulation of filopodium assembly 4/852 47/18722 0.164608468018308 0.385516249202488 SRGAP2C/MYO10/PIK3R1/FMR1 4 GO:0051972 regulation of telomerase activity 4/852 47/18722 0.164608468018308 0.385516249202488 GRHL2/CTNNB1/MAPK3/TP53 4 GO:0061001 regulation of dendritic spine morphogenesis 4/852 47/18722 0.164608468018308 0.385516249202488 PDLIM5/EFNA1/ADAM10/TIAM1 4 GO:0097300 programmed necrotic cell death 4/852 47/18722 0.164608468018308 0.385516249202488 IPMK/ARHGEF2/PYGL/TP53 4 GO:1903170 negative regulation of calcium ion transmembrane transport 4/852 47/18722 0.164608468018308 0.385516249202488 RRAD/SESTD1/FMR1/SRI 4 GO:0046883 regulation of hormone secretion 15/852 249/18722 0.164736203816046 0.385635959909842 SFRP1/TCF7L2/HMGN3/POMC/CAMK2N1/INHA/SOX4/RAB8B/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 15 GO:0001516 prostaglandin biosynthetic process 3/852 31/18722 0.165547842350856 0.385647752936423 PTGES/FABP5/MIF 3 GO:0002063 chondrocyte development 3/852 31/18722 0.165547842350856 0.385647752936423 COL27A1/SERPINH1/BMPR2 3 GO:0032148 activation of protein kinase B activity 3/852 31/18722 0.165547842350856 0.385647752936423 INSR/PINK1/TXN 3 GO:0035115 embryonic forelimb morphogenesis 3/852 31/18722 0.165547842350856 0.385647752936423 CRABP2/CTNNB1/RDH10 3 GO:0043171 peptide catabolic process 3/852 31/18722 0.165547842350856 0.385647752936423 LVRN/ERAP1/CTSH 3 GO:0046457 prostanoid biosynthetic process 3/852 31/18722 0.165547842350856 0.385647752936423 PTGES/FABP5/MIF 3 GO:0070723 response to cholesterol 3/852 31/18722 0.165547842350856 0.385647752936423 TGFB1/ABCA1/DAG1 3 GO:0090162 establishment of epithelial cell polarity 3/852 31/18722 0.165547842350856 0.385647752936423 FAT1/GOLPH3/FRMD4A 3 GO:0090183 regulation of kidney development 3/852 31/18722 0.165547842350856 0.385647752936423 NOG/GATA3/MAGED1 3 GO:0045055 regulated exocytosis 14/852 230/18722 0.16564643656321 0.385647752936423 SYT8/GATA2/STXBP5/SNAP23/MYH9/CTBP2/SDF4/TMED10/LAMP1/S100A13/ARL8B/AP1G1/FMR1/SYNGR2 14 GO:0016126 sterol biosynthetic process 5/852 64/18722 0.16573735140105 0.385647752936423 PRKAG2/APOE/INSIG1/CYB5R3/CYB5R1 5 GO:0030837 negative regulation of actin filament polymerization 5/852 64/18722 0.16573735140105 0.385647752936423 TMSB10/CAPG/MYADM/SSH2/GSN 5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 5/852 64/18722 0.16573735140105 0.385647752936423 HMGN3/CAMK2N1/TIAM1/LRP1/SRI 5 GO:0010639 negative regulation of organelle organization 20/852 347/18722 0.166343426028557 0.386879141960134 F11R/TSPO/TMSB10/CAPG/VAT1/MYADM/LIMA1/PHLDB2/TNKS2/ARHGEF2/DNM2/PINK1/TMEM14A/SSH2/TP53/ARHGEF7/SEC22B/PIK3R1/GSN/MAP4 20 GO:0043624 cellular protein complex disassembly 9/852 136/18722 0.167467541802755 0.389133951012588 SEMA5A/CAPG/LIMA1/ARHGEF2/SH3GL1/DSTN/CCSAP/MICAL3/GSN 9 GO:0098876 vesicle-mediated transport to the plasma membrane 9/852 136/18722 0.167467541802755 0.389133951012588 ANKRD50/DNM2/ARHGAP1/SEC16A/LYPLA1/GOLPH3/KRT18/ACSL3/MACF1 9 GO:0006606 protein import into nucleus 10/852 155/18722 0.169417825825339 0.393484041245468 SMAD3/TGFB1/FLNA/CBLB/PKIG/PPP3CA/TP53/JUP/PIK3R1/IPO7 10 GO:0009308 amine metabolic process 8/852 118/18722 0.16954349764633 0.393594291353312 AOC1/EPAS1/GATA3/MAOA/TGFB2/GDPD3/SAT1/AMD1 8 GO:0002312 B cell activation involved in immune response 6/852 82/18722 0.169704646720649 0.393786762077007 PLCL2/TGFB1/PTK2B/XBP1/NOTCH2/NDFIP1 6 GO:0009749 response to glucose 13/852 212/18722 0.170226745747936 0.394816226428276 TCF7L2/HMGN3/LPL/CAMK2N1/PTK2B/SOX4/ENDOG/XBP1/TIAM1/EGR1/LRP1/PPP3CA/SRI 13 GO:0030879 mammary gland development 9/852 137/18722 0.172543773550296 0.399453915491556 GATA3/PAM/XBP1/CSF1R/NCOR2/RTN4/NCOA1/ZNF703/RREB1 9 GO:0045471 response to ethanol 9/852 137/18722 0.172543773550296 0.399453915491556 HPGD/SPARC/GATA3/SLC23A2/PTK2B/EIF4EBP1/ADCY7/SDF4/ITPR2 9 GO:0050671 positive regulation of lymphocyte proliferation 9/852 137/18722 0.172543773550296 0.399453915491556 IGF2/EBI3/IL6ST/CD276/EFNB1/SLC7A1/EPHB2/CD320/MIF 9 GO:0055123 digestive system development 9/852 137/18722 0.172543773550296 0.399453915491556 IGF2/IL6ST/SFRP1/SMAD3/TGFB2/EDNRB/CTNNB1/KLF5/YIPF6 9 GO:0046513 ceramide biosynthetic process 5/852 65/18722 0.173322098311104 0.40053918883102 UGCG/SGMS2/GBA/CERS6/B4GALT5 5 GO:0048524 positive regulation of viral process 5/852 65/18722 0.173322098311104 0.40053918883102 P4HB/PABPC1/CAV2/DDB1/FMR1 5 GO:0048645 animal organ formation 5/852 65/18722 0.173322098311104 0.40053918883102 NOG/CITED2/CTNNB1/MAPK3/RDH10 5 GO:0002673 regulation of acute inflammatory response 4/852 48/18722 0.173569634579864 0.40053918883102 IL6ST/PTGES/DNASE1L3/EDNRB 4 GO:0002715 regulation of natural killer cell mediated immunity 4/852 48/18722 0.173569634579864 0.40053918883102 HLA-G/PVR/LAMP1/AP1G1 4 GO:0015804 neutral amino acid transport 4/852 48/18722 0.173569634579864 0.40053918883102 SFXN3/SLC1A5/SERINC3/MFSD12 4 GO:0120009 intermembrane lipid transfer 4/852 48/18722 0.173569634579864 0.40053918883102 TSPO/APOE/ABCA1/NPC2 4 GO:0035051 cardiocyte differentiation 10/852 156/18722 0.174185960447451 0.401777240573795 ITGB1/CITED2/PDLIM5/TGFB1/TGFB2/CALR/FHL2/MAPK3/TGFBR3/OBSL1 10 GO:0002285 lymphocyte activation involved in immune response 12/852 194/18722 0.174833378694611 0.403085842863022 GATA3/PLCL2/TGFB1/PTK2B/XBP1/NOTCH2/LAMP1/LGALS3/AP1G1/TP53/NDFIP1/MDK 12 GO:0050672 negative regulation of lymphocyte proliferation 6/852 83/18722 0.176420516751735 0.405814264235897 HLA-G/SDC4/ERBB2/PKN1/CBLB/NDFIP1 6 GO:0003180 aortic valve morphogenesis 3/852 32/18722 0.176903734499018 0.405814264235897 GATA3/TGFB1/EFNA1 3 GO:0010644 cell communication by electrical coupling 3/852 32/18722 0.176903734499018 0.405814264235897 PKP2/GJA5/SRI 3 GO:0014044 Schwann cell development 3/852 32/18722 0.176903734499018 0.405814264235897 LAMB2/DAG1/NDRG1 3 GO:0019228 neuronal action potential 3/852 32/18722 0.176903734499018 0.405814264235897 GBA/P2RX4/FMR1 3 GO:0019934 cGMP-mediated signaling 3/852 32/18722 0.176903734499018 0.405814264235897 PTK2B/APOE/EDNRB 3 GO:0035456 response to interferon-beta 3/852 32/18722 0.176903734499018 0.405814264235897 BST2/CAPN2/UBE2K 3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 3/852 32/18722 0.176903734499018 0.405814264235897 CDKN1C/TNFAIP3/IPO7 3 GO:0051497 negative regulation of stress fiber assembly 3/852 32/18722 0.176903734499018 0.405814264235897 F11R/PHLDB2/PIK3R1 3 GO:0061037 negative regulation of cartilage development 3/852 32/18722 0.176903734499018 0.405814264235897 NOG/LTBP3/CTNNB1 3 GO:1903955 positive regulation of protein targeting to mitochondrion 3/852 32/18722 0.176903734499018 0.405814264235897 RHOU/PINK1/SH3GLB1 3 GO:0032946 positive regulation of mononuclear cell proliferation 9/852 138/18722 0.177690277462591 0.407432877662515 IGF2/EBI3/IL6ST/CD276/EFNB1/SLC7A1/EPHB2/CD320/MIF 9 GO:0030073 insulin secretion 12/852 195/18722 0.179148946508178 0.408206215656096 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 12 GO:0050728 negative regulation of inflammatory response 11/852 176/18722 0.179418450363862 0.408206215656096 GATA3/SMAD3/APOE/GRN/TNFAIP3/PLK2/GBA/LDLR/FURIN/NDFIP1/MDK 11 GO:0002031 G protein-coupled receptor internalization 2/852 17/18722 0.179730771685656 0.408206215656096 ADM/DNM2 2 GO:0006677 glycosylceramide metabolic process 2/852 17/18722 0.179730771685656 0.408206215656096 UGCG/GBA 2 GO:0008340 determination of adult lifespan 2/852 17/18722 0.179730771685656 0.408206215656096 GBA/TP53 2 GO:0009084 glutamine family amino acid biosynthetic process 2/852 17/18722 0.179730771685656 0.408206215656096 PYCR1/GLS 2 GO:0010470 regulation of gastrulation 2/852 17/18722 0.179730771685656 0.408206215656096 PHLDB2/DAG1 2 GO:0010831 positive regulation of myotube differentiation 2/852 17/18722 0.179730771685656 0.408206215656096 ATP11A/MMP14 2 GO:0021692 cerebellar Purkinje cell layer morphogenesis 2/852 17/18722 0.179730771685656 0.408206215656096 HERC1/GBA 2 GO:0042448 progesterone metabolic process 2/852 17/18722 0.179730771685656 0.408206215656096 ADM/EGR1 2 GO:0042772 DNA damage response, signal transduction resulting in transcription 2/852 17/18722 0.179730771685656 0.408206215656096 RPS27L/TP53 2 GO:0060263 regulation of respiratory burst 2/852 17/18722 0.179730771685656 0.408206215656096 GRN/INSR 2 GO:0070875 positive regulation of glycogen metabolic process 2/852 17/18722 0.179730771685656 0.408206215656096 IGF2/INSR 2 GO:0072673 lamellipodium morphogenesis 2/852 17/18722 0.179730771685656 0.408206215656096 ARHGEF7/RREB1 2 GO:0090136 epithelial cell-cell adhesion 2/852 17/18722 0.179730771685656 0.408206215656096 VCL/JUP 2 GO:0090399 replicative senescence 2/852 17/18722 0.179730771685656 0.408206215656096 SERPINE1/TP53 2 GO:1901550 regulation of endothelial cell development 2/852 17/18722 0.179730771685656 0.408206215656096 F11R/VCL 2 GO:1903140 regulation of establishment of endothelial barrier 2/852 17/18722 0.179730771685656 0.408206215656096 F11R/VCL 2 GO:1903358 regulation of Golgi organization 2/852 17/18722 0.179730771685656 0.408206215656096 DNM2/MAPK3 2 GO:1903541 regulation of exosomal secretion 2/852 17/18722 0.179730771685656 0.408206215656096 SDC4/SDC1 2 GO:1904355 positive regulation of telomere capping 2/852 17/18722 0.179730771685656 0.408206215656096 TNKS2/MAPK3 2 GO:0050922 negative regulation of chemotaxis 5/852 66/18722 0.181037290042793 0.41061770202135 SEMA5A/SEMA4C/MIF/SEMA7A/DPP4 5 GO:2000272 negative regulation of signaling receptor activity 5/852 66/18722 0.181037290042793 0.41061770202135 IL18BP/GPRC5A/EPHB2/CBLB/ERRFI1 5 GO:2000573 positive regulation of DNA biosynthetic process 5/852 66/18722 0.181037290042793 0.41061770202135 PTK2B/TNKS2/GRHL2/CTNNB1/MAPK3 5 GO:0034249 negative regulation of cellular amide metabolic process 16/852 273/18722 0.181456330604503 0.411382753122731 ABCA7/MEX3D/APOE/IGF2BP2/EIF4EBP1/CALR/EIF4EBP2/RTN4/PABPC1/DAPK1/ZFP36L1/RNF139/FMR1/ATF4/RTN2/IGF2BP3 16 GO:0009066 aspartate family amino acid metabolic process 4/852 49/18722 0.182694150241642 0.413123247538957 PLOD3/PLOD2/PIPOX/ATF4 4 GO:0046580 negative regulation of Ras protein signal transduction 4/852 49/18722 0.182694150241642 0.413123247538957 TIMP2/ITGB1/TGFB2/EPHB2 4 GO:0060986 endocrine hormone secretion 4/852 49/18722 0.182694150241642 0.413123247538957 GATA3/POMC/INHA/RAB8B 4 GO:0072091 regulation of stem cell proliferation 4/852 49/18722 0.182694150241642 0.413123247538957 FBLN1/LTBP3/ZFP36L1/CCNE1 4 GO:1904894 positive regulation of receptor signaling pathway via STAT 4/852 49/18722 0.182694150241642 0.413123247538957 MGAT5/CSH1/TGFB1/PTK2B 4 GO:0014897 striated muscle hypertrophy 7/852 102/18722 0.182716540636145 0.413123247538957 IL6ST/PDLIM5/SMAD3/TIAM1/PPP3CA/P2RX4/ERRFI1 7 GO:0032945 negative regulation of mononuclear cell proliferation 6/852 84/18722 0.183242526614869 0.414126464505001 HLA-G/SDC4/ERBB2/PKN1/CBLB/NDFIP1 6 GO:0045930 negative regulation of mitotic cell cycle 14/852 235/18722 0.185192475214785 0.41834547924417 TIMP2/SMAD3/TGFB1/SOX4/CDKN1C/RPS27L/PLK2/CTNNB1/ZFP36L1/JADE1/CTDSP1/TP53/PTPN3/WEE1 14 GO:0043244 regulation of protein-containing complex disassembly 8/852 121/18722 0.186326811459061 0.420530422454464 SEMA5A/CAPG/LIMA1/INSR/ARHGEF2/GBA/DSTN/GSN 8 GO:0043500 muscle adaptation 8/852 121/18722 0.186326811459061 0.420530422454464 IL6ST/SMAD3/FBXO32/DAG1/PPP3CA/P2RX4/GSN/ERRFI1 8 GO:0050870 positive regulation of T cell activation 13/852 216/18722 0.186725157367392 0.421240572402548 IGF2/EBI3/IL6ST/HLA-G/GATA3/CD276/EFNB1/SLC7A1/SOX4/XBP1/MDK/HSPH1/DPP4 13 GO:0007292 female gamete generation 9/852 140/18722 0.188188518710951 0.422646416064037 HPGD/HEXB/NRIP1/PTN/ADAMTS1/PTK2B/CTNNB1/PAQR7/MDK 9 GO:0010259 multicellular organism aging 3/852 33/18722 0.18846645092151 0.422646416064037 GBA/TP53/SEC63 3 GO:0010984 regulation of lipoprotein particle clearance 3/852 33/18722 0.18846645092151 0.422646416064037 APOC1/LIPG/CNPY2 3 GO:0021696 cerebellar cortex morphogenesis 3/852 33/18722 0.18846645092151 0.422646416064037 SERPINE2/HERC1/GBA 3 GO:0032633 interleukin-4 production 3/852 33/18722 0.18846645092151 0.422646416064037 IL1RAP/GATA3/NDFIP1 3 GO:0032673 regulation of interleukin-4 production 3/852 33/18722 0.18846645092151 0.422646416064037 IL1RAP/GATA3/NDFIP1 3 GO:0048730 epidermis morphogenesis 3/852 33/18722 0.18846645092151 0.422646416064037 PLOD3/TGFB2/CTNNB1 3 GO:0050901 leukocyte tethering or rolling 3/852 33/18722 0.18846645092151 0.422646416064037 ITGB1/JAM2/GOLPH3 3 GO:1902692 regulation of neuroblast proliferation 3/852 33/18722 0.18846645092151 0.422646416064037 PTN/CTNNB1/TP53 3 GO:0006109 regulation of carbohydrate metabolic process 11/852 178/18722 0.188696702384902 0.422646416064037 IGF2/PRKAG2/POMC/TGFB1/PTK2B/FAM3C/INSR/SCARB2/PPP1CB/TP53/DDB1 11 GO:0051170 import into nucleus 10/852 159/18722 0.188860582186332 0.422646416064037 SMAD3/TGFB1/FLNA/CBLB/PKIG/PPP3CA/TP53/JUP/PIK3R1/IPO7 10 GO:0009880 embryonic pattern specification 5/852 67/18722 0.188877360581611 0.422646416064037 SMAD3/EFNB1/PCSK6/TMED2/CTNNB1 5 GO:0010517 regulation of phospholipase activity 5/852 67/18722 0.188877360581611 0.422646416064037 FLT1/FGFR1/LRP1/ARF4/GNAQ 5 GO:0042130 negative regulation of T cell proliferation 5/852 67/18722 0.188877360581611 0.422646416064037 HLA-G/SDC4/ERBB2/CBLB/NDFIP1 5 GO:0048814 regulation of dendrite morphogenesis 5/852 67/18722 0.188877360581611 0.422646416064037 TIAM1/PPP3CA/ID1/CUX1/OBSL1 5 GO:0061180 mammary gland epithelium development 5/852 67/18722 0.188877360581611 0.422646416064037 GATA3/CSF1R/RTN4/ZNF703/RREB1 5 GO:0061371 determination of heart left/right asymmetry 5/852 67/18722 0.188877360581611 0.422646416064037 ENG/CITED2/SMAD3/NOTCH2/TMED2 5 GO:0030593 neutrophil chemotaxis 7/852 103/18722 0.188943857767551 0.422646416064037 ITGA1/TGFB2/PPIB/LGALS3/BSG/MDK/DPP4 7 GO:0090277 positive regulation of peptide hormone secretion 7/852 103/18722 0.188943857767551 0.422646416064037 TCF7L2/CAMK2N1/SOX4/RAB8B/ACSL4/LRP1/SRI 7 GO:0055072 iron ion homeostasis 6/852 85/18722 0.190167051817043 0.424816143717344 EPAS1/SLC39A8/PICALM/NDFIP1/SRI/ATP6AP1 6 GO:0060021 roof of mouth development 6/852 85/18722 0.190167051817043 0.424816143717344 TGFB2/EPHB2/INSIG1/DHRS3/PLEKHA1/TGFBR3 6 GO:0071277 cellular response to calcium ion 6/852 85/18722 0.190167051817043 0.424816143717344 SYT8/ENDOG/CLIC4/FOSB/IQGAP1/NCSTN 6 GO:1903522 regulation of blood circulation 15/852 256/18722 0.191167879569717 0.426862439163436 TPM1/EPAS1/ADM/DOCK5/TGFB2/KCNJ2/FLNA/GAA/PKP2/BMPR2/DSG2/GJA5/P2RX4/JUP/SRI 15 GO:0050873 brown fat cell differentiation 4/852 50/18722 0.191972345557231 0.427709966883375 DIO2/PLAC8/ERO1A/RREB1 4 GO:0070231 T cell apoptotic process 4/852 50/18722 0.191972345557231 0.427709966883375 EFNA1/LGALS3/KDELR1/TP53 4 GO:1901570 fatty acid derivative biosynthetic process 4/852 50/18722 0.191972345557231 0.427709966883375 PAM/TECR/ACSL4/ACSL3 4 GO:1903747 regulation of establishment of protein localization to mitochondrion 4/852 50/18722 0.191972345557231 0.427709966883375 RHOU/LMAN1/PINK1/SH3GLB1 4 GO:2000677 regulation of transcription regulatory region DNA binding 4/852 50/18722 0.191972345557231 0.427709966883375 GATA3/TGFB1/CTNNB1/SRI 4 GO:1990266 neutrophil migration 8/852 122/18722 0.192073995998599 0.427747089319005 IL1R1/ITGA1/TGFB2/PPIB/LGALS3/BSG/MDK/DPP4 8 GO:0050864 regulation of B cell activation 12/852 198/18722 0.192396371941158 0.428275515249822 SFRP1/TGFB1/INHA/EPHB2/XBP1/MMP14/TNFAIP3/PKN1/CD320/ZFP36L1/MIF/NDFIP1 12 GO:1901617 organic hydroxy compound biosynthetic process 14/852 237/18722 0.193310456474955 0.429236933644585 GATA3/PRKAG2/TGFB2/PTK2B/APOE/IPMK/INSIG1/H6PD/GBA/OPN3/CYB5R3/MFSD12/CYB5R1/IMPA2 14 GO:0009314 response to radiation 25/852 456/18722 0.194236961183382 0.429236933644585 ITGB1/SFRP1/PTN/GATA3/TIMP1/MMP2/F11R/ABCA7/DNM2/SCARA3/SDF4/TXN/EGR1/OPN3/PPP1CB/NPTN/TP53/DDB1/GNAQ/SLC1A3/PIK3R1/TP53I13/FMR1/ATF4/UBE2A 25 GO:1903037 regulation of leukocyte cell-cell adhesion 19/852 336/18722 0.195003111222677 0.429236933644585 IGF2/EBI3/IL6ST/HLA-G/GATA3/SDC4/ERBB2/CD276/EFNB1/SLC7A1/SOX4/XBP1/CBLB/LGALS3/NDFIP1/MDK/HSPH1/NFAT5/DPP4 19 GO:0030217 T cell differentiation 15/852 257/18722 0.195102029560991 0.429236933644585 HLA-G/GATA3/ERBB2/SOX4/CTSL/XBP1/CTNNB1/GBA/ZFP36L1/EGR1/KDELR1/TP53/MDK/ADAM17/CLPTM1 15 GO:0045088 regulation of innate immune response 13/852 218/18722 0.195249222313096 0.429236933644585 HLA-G/SERPING1/PVR/APOE/GRN/ISG15/TNFAIP3/STAT2/LAMP1/ERAP1/AP1G1/XIAP/UBE2K 13 GO:0014896 muscle hypertrophy 7/852 104/18722 0.195256269195984 0.429236933644585 IL6ST/PDLIM5/SMAD3/TIAM1/PPP3CA/P2RX4/ERRFI1 7 GO:0001946 lymphangiogenesis 2/852 18/18722 0.196445665680936 0.429236933644585 ACVRL1/BMPR2 2 GO:0002544 chronic inflammatory response 2/852 18/18722 0.196445665680936 0.429236933644585 PTGES/TNFAIP3 2 GO:0002643 regulation of tolerance induction 2/852 18/18722 0.196445665680936 0.429236933644585 HLA-G/CBLB 2 GO:0010663 positive regulation of striated muscle cell apoptotic process 2/852 18/18722 0.196445665680936 0.429236933644585 CAPN2/TP53 2 GO:0010666 positive regulation of cardiac muscle cell apoptotic process 2/852 18/18722 0.196445665680936 0.429236933644585 CAPN2/TP53 2 GO:0015693 magnesium ion transport 2/852 18/18722 0.196445665680936 0.429236933644585 KCNJ2/MAGT1 2 GO:0030299 intestinal cholesterol absorption 2/852 18/18722 0.196445665680936 0.429236933644585 LIMA1/LDLR 2 GO:0031649 heat generation 2/852 18/18722 0.196445665680936 0.429236933644585 PTGES/EDNRB 2 GO:0032305 positive regulation of icosanoid secretion 2/852 18/18722 0.196445665680936 0.429236933644585 PTGES/P2RX4 2 GO:0032634 interleukin-5 production 2/852 18/18722 0.196445665680936 0.429236933644585 IL1RAP/GATA3 2 GO:0032674 regulation of interleukin-5 production 2/852 18/18722 0.196445665680936 0.429236933644585 IL1RAP/GATA3 2 GO:0034162 toll-like receptor 9 signaling pathway 2/852 18/18722 0.196445665680936 0.429236933644585 PTPRS/RTN4 2 GO:0034433 steroid esterification 2/852 18/18722 0.196445665680936 0.429236933644585 APOC1/APOE 2 GO:0034434 sterol esterification 2/852 18/18722 0.196445665680936 0.429236933644585 APOC1/APOE 2 GO:0034435 cholesterol esterification 2/852 18/18722 0.196445665680936 0.429236933644585 APOC1/APOE 2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 2/852 18/18722 0.196445665680936 0.429236933644585 IL1R1/GATA3 2 GO:0048643 positive regulation of skeletal muscle tissue development 2/852 18/18722 0.196445665680936 0.429236933644585 IGF2/CTNNB1 2 GO:0055070 copper ion homeostasis 2/852 18/18722 0.196445665680936 0.429236933644585 ANKRD9/XIAP 2 GO:0060008 Sertoli cell differentiation 2/852 18/18722 0.196445665680936 0.429236933644585 FLNA/SDC1 2 GO:0060192 negative regulation of lipase activity 2/852 18/18722 0.196445665680936 0.429236933644585 APOC1/ANGPTL4 2 GO:0060438 trachea development 2/852 18/18722 0.196445665680936 0.429236933644585 CTNNB1/MAPK3 2 GO:0060716 labyrinthine layer blood vessel development 2/852 18/18722 0.196445665680936 0.429236933644585 PLCD3/TMED2 2 GO:0061484 hematopoietic stem cell homeostasis 2/852 18/18722 0.196445665680936 0.429236933644585 FSTL1/SOX4 2 GO:0071318 cellular response to ATP 2/852 18/18722 0.196445665680936 0.429236933644585 HSP90B1/P2RX4 2 GO:0071800 podosome assembly 2/852 18/18722 0.196445665680936 0.429236933644585 SH3PXD2B/GSN 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/852 18/18722 0.196445665680936 0.429236933644585 NOG/MAGED1 2 GO:0090493 catecholamine uptake 2/852 18/18722 0.196445665680936 0.429236933644585 SLC6A2/ACTB 2 GO:0097094 craniofacial suture morphogenesis 2/852 18/18722 0.196445665680936 0.429236933644585 MMP14/INSIG1 2 GO:0097107 postsynaptic density assembly 2/852 18/18722 0.196445665680936 0.429236933644585 IL1RAP/PTPRS 2 GO:0099558 maintenance of synapse structure 2/852 18/18722 0.196445665680936 0.429236933644585 CTBP2/SDF4 2 GO:0150079 negative regulation of neuroinflammatory response 2/852 18/18722 0.196445665680936 0.429236933644585 GRN/LDLR 2 GO:1900006 positive regulation of dendrite development 2/852 18/18722 0.196445665680936 0.429236933644585 PTN/IQGAP1 2 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/852 18/18722 0.196445665680936 0.429236933644585 PABPC1/ZFP36L1 2 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 2/852 18/18722 0.196445665680936 0.429236933644585 BMPR2/CTNNB1 2 GO:2000641 regulation of early endosome to late endosome transport 2/852 18/18722 0.196445665680936 0.429236933644585 MAPK3/EZR 2 GO:0007585 respiratory gaseous exchange by respiratory system 5/852 68/18722 0.196836646702106 0.429236933644585 CSF2RB/GAA/MAN2A1/GLS/MAN1A2 5 GO:0034394 protein localization to cell surface 5/852 68/18722 0.196836646702106 0.429236933644585 ABCA7/FLNA/CTNNB1/PICALM/VCL 5 GO:0042267 natural killer cell mediated cytotoxicity 5/852 68/18722 0.196836646702106 0.429236933644585 HLA-G/PVR/LAMP1/ARL8B/AP1G1 5 GO:0051926 negative regulation of calcium ion transport 5/852 68/18722 0.196836646702106 0.429236933644585 RRAD/SESTD1/TMBIM6/FMR1/SRI 5 GO:1901607 alpha-amino acid biosynthetic process 5/852 68/18722 0.196836646702106 0.429236933644585 PLOD3/PLOD2/PYCR1/GLS/SERINC3 5 GO:1902305 regulation of sodium ion transmembrane transport 5/852 68/18722 0.196836646702106 0.429236933644585 FXYD5/GLRX/DNM2/ACTN4/PTPN3 5 GO:0006690 icosanoid metabolic process 8/852 123/18722 0.197894348995071 0.43135654330541 HPGD/PTGES/ACOX1/MGLL/FABP5/MIF/MAPK3/GPX4 8 GO:0048660 regulation of smooth muscle cell proliferation 11/852 180/18722 0.198189069209755 0.431372897305522 TPM1/HPGD/IGFBP3/TCF7L2/ADAMTS1/MMP2/TGFB1/APOE/TNFAIP3/BMPR2/CTNNB1 11 GO:0001818 negative regulation of cytokine production 20/852 357/18722 0.198638307152387 0.431372897305522 FN1/GATA3/TSPO/IL1R2/POMC/PTPRS/TGFB1/TGFB2/INHA/TNFAIP3/ANXA4/GBA/ADCY7/BST2/FURIN/NPTN/EZR/NDFIP1/ERRFI1/CHID1 20 GO:2000045 regulation of G1/S transition of mitotic cell cycle 9/852 142/18722 0.198950650922876 0.431372897305522 ADAMTS1/SOX4/RPS27L/PLK2/JADE1/CTDSP1/TP53/WEE1/ADAM17 9 GO:0034764 positive regulation of transmembrane transport 13/852 219/18722 0.199577604315351 0.431372897305522 ITGB1/EPHB2/KCNJ2/FLNA/GLRX/IFNGR2/INSR/DNM2/PINK1/OPN3/ACTN4/PIK3R1/SRI 13 GO:0001662 behavioral fear response 3/852 34/18722 0.200215992073455 0.431372897305522 APOE/MDK/DPP4 3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 3/852 34/18722 0.200215992073455 0.431372897305522 CTSL/DNM2/CTSF 3 GO:0006356 regulation of transcription by RNA polymerase I 3/852 34/18722 0.200215992073455 0.431372897305522 ERBB2/FLNA/ATF4 3 GO:0009649 entrainment of circadian clock 3/852 34/18722 0.200215992073455 0.431372897305522 PPP1CB/TP53/GNAQ 3 GO:0010614 negative regulation of cardiac muscle hypertrophy 3/852 34/18722 0.200215992073455 0.431372897305522 SMAD3/P2RX4/ERRFI1 3 GO:0010922 positive regulation of phosphatase activity 3/852 34/18722 0.200215992073455 0.431372897305522 ITGA1/SMAD3/PPP1R15B 3 GO:0019076 viral release from host cell 3/852 34/18722 0.200215992073455 0.431372897305522 CAV2/ARL8B/DDB1 3 GO:0019320 hexose catabolic process 3/852 34/18722 0.200215992073455 0.431372897305522 TP53/GLB1/GALE 3 GO:0032212 positive regulation of telomere maintenance via telomerase 3/852 34/18722 0.200215992073455 0.431372897305522 TNKS2/CTNNB1/MAPK3 3 GO:0034383 low-density lipoprotein particle clearance 3/852 34/18722 0.200215992073455 0.431372897305522 SCARB1/LDLR/CNPY2 3 GO:0035890 exit from host 3/852 34/18722 0.200215992073455 0.431372897305522 CAV2/ARL8B/DDB1 3 GO:0035891 exit from host cell 3/852 34/18722 0.200215992073455 0.431372897305522 CAV2/ARL8B/DDB1 3 GO:0043276 anoikis 3/852 34/18722 0.200215992073455 0.431372897305522 ITGA5/ITGB1/PTK2 3 GO:0048261 negative regulation of receptor-mediated endocytosis 3/852 34/18722 0.200215992073455 0.431372897305522 APOC1/ANKRD13A/PICALM 3 GO:0048536 spleen development 3/852 34/18722 0.200215992073455 0.431372897305522 CITED2/PKN1/ADAM17 3 GO:0048741 skeletal muscle fiber development 3/852 34/18722 0.200215992073455 0.431372897305522 RCAN1/CAV2/PPP3CA 3 GO:0050931 pigment cell differentiation 3/852 34/18722 0.200215992073455 0.431372897305522 CD63/EDNRB/AP1G1 3 GO:0051085 chaperone cofactor-dependent protein refolding 3/852 34/18722 0.200215992073455 0.431372897305522 ERO1A/HSPH1/SDF2L1 3 GO:0051973 positive regulation of telomerase activity 3/852 34/18722 0.200215992073455 0.431372897305522 GRHL2/CTNNB1/MAPK3 3 GO:0070232 regulation of T cell apoptotic process 3/852 34/18722 0.200215992073455 0.431372897305522 EFNA1/LGALS3/TP53 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/852 34/18722 0.200215992073455 0.431372897305522 FLNA/PKP2/GJA5 3 GO:0098751 bone cell development 3/852 34/18722 0.200215992073455 0.431372897305522 FBN1/NOTCH2/ATP6AP1 3 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/852 34/18722 0.200215992073455 0.431372897305522 GATA3/SOX4/MAPK3 3 GO:0006636 unsaturated fatty acid biosynthetic process 4/852 51/18722 0.20139449507825 0.43242866490852 PTGES/FADS3/FABP5/MIF 4 GO:0009948 anterior/posterior axis specification 4/852 51/18722 0.20139449507825 0.43242866490852 PCSK6/TMED2/CTNNB1/ETS2 4 GO:0032873 negative regulation of stress-activated MAPK cascade 4/852 51/18722 0.20139449507825 0.43242866490852 SFRP1/PINK1/HIPK3/EZR 4 GO:0045104 intermediate filament cytoskeleton organization 4/852 51/18722 0.20139449507825 0.43242866490852 PKP2/CSNK1A1/KRT18/MACF1 4 GO:0045661 regulation of myoblast differentiation 4/852 51/18722 0.20139449507825 0.43242866490852 IGFBP3/TGFB1/ID3/ZFP36L1 4 GO:0050982 detection of mechanical stimulus 4/852 51/18722 0.20139449507825 0.43242866490852 SERPINE2/CTNNB1/PTK2/JUP 4 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 4/852 51/18722 0.20139449507825 0.43242866490852 SFRP1/PINK1/HIPK3/EZR 4 GO:0051403 stress-activated MAPK cascade 14/852 239/18722 0.201592766528844 0.43242866490852 SFRP1/SMAD3/TGFB2/PTK2B/CDC42EP5/SEMA4C/SASH1/PINK1/ZFP36L1/MAPK3/HIPK3/EZR/SH2D3A/EMC10 14 GO:0072593 reactive oxygen species metabolic process 14/852 239/18722 0.201592766528844 0.43242866490852 PRCP/TSPO/SH3PXD2A/SH3PXD2B/TGFB1/PTK2B/PRDX4/SOD3/ACOX1/PINK1/MYCN/ARF4/TP53/RFK 14 GO:1903039 positive regulation of leukocyte cell-cell adhesion 14/852 239/18722 0.201592766528844 0.43242866490852 IGF2/EBI3/IL6ST/HLA-G/GATA3/CD276/EFNB1/SLC7A1/SOX4/XBP1/MDK/HSPH1/NFAT5/DPP4 14 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7/852 105/18722 0.201651117929723 0.43242866490852 CDC42EP5/NCKAP1/DNM2/CDC42EP1/PIK3R1/FMR1/EPS8L2 7 GO:0099504 synaptic vesicle cycle 11/852 181/18722 0.203013065921419 0.435163867454218 SYT8/STXBP5/ACTB/CANX/SNAP23/CTNNB1/DNM2/PICALM/CTBP2/SH3GL1/FMR1 11 GO:0051262 protein tetramerization 6/852 87/18722 0.204308745748445 0.437382355317704 KCNJ2/VASP/GLS/EVL/TP53/KRT10 6 GO:1900182 positive regulation of protein localization to nucleus 6/852 87/18722 0.204308745748445 0.437382355317704 SMAD3/WWTR1/TGFB1/FLNA/JUP/PIK3R1 6 GO:1901879 regulation of protein depolymerization 6/852 87/18722 0.204308745748445 0.437382355317704 SEMA5A/CAPG/LIMA1/ARHGEF2/DSTN/GSN 6 GO:0006865 amino acid transport 9/852 143/18722 0.204426860461828 0.437449144857305 ITGB1/SLC7A1/SFXN3/SLC1A5/SLC38A10/SLC17A5/SERINC3/SLC1A3/MFSD12 9 GO:0003143 embryonic heart tube morphogenesis 5/852 69/18722 0.204909402998042 0.437737277287414 ENG/CITED2/SMAD3/NOTCH2/TMED2 5 GO:0010611 regulation of cardiac muscle hypertrophy 5/852 69/18722 0.204909402998042 0.437737277287414 IL6ST/SMAD3/PPP3CA/P2RX4/ERRFI1 5 GO:0015807 L-amino acid transport 5/852 69/18722 0.204909402998042 0.437737277287414 ITGB1/SLC7A1/SLC1A5/SERINC3/SLC1A3 5 GO:0060193 positive regulation of lipase activity 5/852 69/18722 0.204909402998042 0.437737277287414 FLT1/FGFR1/ARF4/GNAQ/RHOC 5 GO:0099177 regulation of trans-synaptic signaling 24/852 440/18722 0.206937426410603 0.4418820819366 SERPINE2/ITGB1/PTN/PLCL2/RASGRF2/PTPRS/PTK2B/APOE/EPHB2/STXBP5/PLK2/DLGAP4/EIF4EBP2/FABP5/PINK1/SH3GL1/DGKZ/YWHAG/PPP3CA/NPTN/SLC1A3/NCSTN/FMR1/ATF4 24 GO:0001824 blastocyst development 7/852 106/18722 0.208125688759186 0.443666493657342 CITED2/CMTM3/SMIM14/RTN4/CAPN2/FURIN/UBE2A 7 GO:0002793 positive regulation of peptide secretion 7/852 106/18722 0.208125688759186 0.443666493657342 TCF7L2/CAMK2N1/SOX4/RAB8B/ACSL4/LRP1/SRI 7 GO:0006766 vitamin metabolic process 7/852 106/18722 0.208125688759186 0.443666493657342 SLC23A2/CYP11A1/CD320/LMBRD1/VKORC1/RDH10/RFK 7 GO:0006906 vesicle fusion 7/852 106/18722 0.208125688759186 0.443666493657342 RAB8B/SNAP23/CAV2/USO1/ARL8B/SEC22B/YIPF5 7 GO:0071322 cellular response to carbohydrate stimulus 10/852 163/18722 0.209247068111115 0.445868117613566 HMGN3/CAMK2N1/SOX4/ENDOG/XBP1/TIAM1/ZFP36L1/LRP1/PPP3CA/SRI 10 GO:0018210 peptidyl-threonine modification 8/852 125/18722 0.209746517269187 0.446275023566886 PRKAG2/GALNT3/TGFB1/GALNT2/PKN1/HIPK3/GALNT1/UBE2K 8 GO:0044843 cell cycle G1/S phase transition 14/852 241/18722 0.210034443957807 0.446275023566886 ITGB1/ADAMTS1/SOX4/RPS27L/EIF4EBP1/PLK2/JADE1/CTDSP1/PPP3CA/TP53/BCAT1/WEE1/ADAM17/CCNE1 14 GO:0034204 lipid translocation 4/852 52/18722 0.210950847528316 0.446275023566886 ABCA7/MFSD2A/ATP11A/ABCA1 4 GO:0045103 intermediate filament-based process 4/852 52/18722 0.210950847528316 0.446275023566886 PKP2/CSNK1A1/KRT18/MACF1 4 GO:0002209 behavioral defense response 3/852 35/18722 0.212132733760508 0.446275023566886 APOE/MDK/DPP4 3 GO:0015695 organic cation transport 3/852 35/18722 0.212132733760508 0.446275023566886 RALBP1/SLC44A2/SEC14L1 3 GO:0021955 central nervous system neuron axonogenesis 3/852 35/18722 0.212132733760508 0.446275023566886 EPHB2/C12orf57/B4GALT5 3 GO:0032232 negative regulation of actin filament bundle assembly 3/852 35/18722 0.212132733760508 0.446275023566886 F11R/PHLDB2/PIK3R1 3 GO:0034331 cell junction maintenance 3/852 35/18722 0.212132733760508 0.446275023566886 CSF1R/CTBP2/SDF4 3 GO:0045454 cell redox homeostasis 3/852 35/18722 0.212132733760508 0.446275023566886 PRDX4/TXN/ERO1A 3 GO:0045922 negative regulation of fatty acid metabolic process 3/852 35/18722 0.212132733760508 0.446275023566886 APOC1/MFSD2A/INSIG1 3 GO:0086005 ventricular cardiac muscle cell action potential 3/852 35/18722 0.212132733760508 0.446275023566886 PKP2/DSG2/JUP 3 GO:0002548 monocyte chemotaxis 5/852 70/18722 0.21308981646321 0.446275023566886 FLT1/SERPINE1/PLA2G7/CCR1/LGALS3 5 GO:0002396 MHC protein complex assembly 2/852 19/18722 0.213339500636187 0.446275023566886 TAPBP/CALR 2 GO:0002523 leukocyte migration involved in inflammatory response 2/852 19/18722 0.213339500636187 0.446275023566886 PTN/MDK 2 GO:0003085 negative regulation of systemic arterial blood pressure 2/852 19/18722 0.213339500636187 0.446275023566886 PRCP/BMPR2 2 GO:0006309 apoptotic DNA fragmentation 2/852 19/18722 0.213339500636187 0.446275023566886 DNASE1L3/ENDOG 2 GO:0010829 negative regulation of glucose transmembrane transport 2/852 19/18722 0.213339500636187 0.446275023566886 PEA15/FABP5 2 GO:0016082 synaptic vesicle priming 2/852 19/18722 0.213339500636187 0.446275023566886 STXBP5/SNAP23 2 GO:0030220 platelet formation 2/852 19/18722 0.213339500636187 0.446275023566886 MYH9/ACTN1 2 GO:0031065 positive regulation of histone deacetylation 2/852 19/18722 0.213339500636187 0.446275023566886 PINK1/TP53 2 GO:0032011 ARF protein signal transduction 2/852 19/18722 0.213339500636187 0.446275023566886 IQSEC1/MAPRE2 2 GO:0032012 regulation of ARF protein signal transduction 2/852 19/18722 0.213339500636187 0.446275023566886 IQSEC1/MAPRE2 2 GO:0032616 interleukin-13 production 2/852 19/18722 0.213339500636187 0.446275023566886 IL1RAP/GATA3 2 GO:0032656 regulation of interleukin-13 production 2/852 19/18722 0.213339500636187 0.446275023566886 IL1RAP/GATA3 2 GO:0035461 vitamin transmembrane transport 2/852 19/18722 0.213339500636187 0.446275023566886 SLC23A2/SCARB1 2 GO:0036344 platelet morphogenesis 2/852 19/18722 0.213339500636187 0.446275023566886 MYH9/ACTN1 2 GO:0038092 nodal signaling pathway 2/852 19/18722 0.213339500636187 0.446275023566886 CITED2/SMAD3 2 GO:0043031 negative regulation of macrophage activation 2/852 19/18722 0.213339500636187 0.446275023566886 GRN/LDLR 2 GO:0044320 cellular response to leptin stimulus 2/852 19/18722 0.213339500636187 0.446275023566886 EBI3/UGCG 2 GO:0045603 positive regulation of endothelial cell differentiation 2/852 19/18722 0.213339500636187 0.446275023566886 ACVRL1/CTNNB1 2 GO:0045780 positive regulation of bone resorption 2/852 19/18722 0.213339500636187 0.446275023566886 LTBP3/ATP6AP1 2 GO:0060065 uterus development 2/852 19/18722 0.213339500636187 0.446275023566886 GATA3/TGFB2 2 GO:0061323 cell proliferation involved in heart morphogenesis 2/852 19/18722 0.213339500636187 0.446275023566886 BMPR2/CTNNB1 2 GO:0070262 peptidyl-serine dephosphorylation 2/852 19/18722 0.213339500636187 0.446275023566886 PPP3CA/PPP1R15B 2 GO:0086014 atrial cardiac muscle cell action potential 2/852 19/18722 0.213339500636187 0.446275023566886 FLNA/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/852 19/18722 0.213339500636187 0.446275023566886 FLNA/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/852 19/18722 0.213339500636187 0.446275023566886 FLNA/GJA5 2 GO:0098780 response to mitochondrial depolarisation 2/852 19/18722 0.213339500636187 0.446275023566886 GBA/PINK1 2 GO:1901739 regulation of myoblast fusion 2/852 19/18722 0.213339500636187 0.446275023566886 GDF15/CAPN2 2 GO:1901881 positive regulation of protein depolymerization 2/852 19/18722 0.213339500636187 0.446275023566886 SEMA5A/DSTN 2 GO:1903978 regulation of microglial cell activation 2/852 19/18722 0.213339500636187 0.446275023566886 GRN/LDLR 2 GO:2000269 regulation of fibroblast apoptotic process 2/852 19/18722 0.213339500636187 0.446275023566886 SFRP1/TP53 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/852 19/18722 0.213339500636187 0.446275023566886 DNM2/PIK3CB 2 GO:0002790 peptide secretion 14/852 242/18722 0.214313421147067 0.448126069228578 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/RAB8B/ABCA1/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 14 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 10/852 164/18722 0.214481893762491 0.448142021034554 PTK2B/PLK2/GBA/ANKIB1/PTK2/HERPUD1/RNF144B/RNF139/CSNK1A1/UBE2K 10 GO:0032526 response to retinoic acid 7/852 107/18722 0.214677212937475 0.448142021034554 PTGES/PTK2B/ABCA1/NCOA1/IGF2R/RXRA/CTSH 7 GO:0071868 cellular response to monoamine stimulus 7/852 107/18722 0.214677212937475 0.448142021034554 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0071870 cellular response to catecholamine stimulus 7/852 107/18722 0.214677212937475 0.448142021034554 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0043524 negative regulation of neuron apoptotic process 9/852 145/18722 0.215561593663979 0.449801617293037 PTK2B/APOE/GRN/WFS1/GBA/PINK1/ERBB3/LRP1/MDK 9 GO:0031929 TOR signaling 8/852 126/18722 0.215774197328638 0.450044404492283 GATA3/EIF4EBP1/EIF4EBP2/SH3BP4/GBA/PINK1/RHEB/GOLPH3 8 GO:0051251 positive regulation of lymphocyte activation 20/852 362/18722 0.215856783716346 0.450044404492283 IGF2/EBI3/IL6ST/HLA-G/GATA3/CD276/TGFB1/EFNB1/SLC7A1/EPHB2/SOX4/XBP1/MMP14/CD320/LAMP1/MIF/AP1G1/MDK/HSPH1/DPP4 20 GO:0048659 smooth muscle cell proliferation 11/852 184/18722 0.217783752856801 0.453686104357731 TPM1/HPGD/IGFBP3/TCF7L2/ADAMTS1/MMP2/TGFB1/APOE/TNFAIP3/BMPR2/CTNNB1 11 GO:2001257 regulation of cation channel activity 11/852 184/18722 0.217783752856801 0.453686104357731 RRAD/ITGB1/RASGRF2/PTK2B/EPHB2/IFNGR2/DAPK1/PINK1/AHNAK/FMR1/SRI 11 GO:0051781 positive regulation of cell division 6/852 89/18722 0.218815096370818 0.455645999186731 IGF2/PTN/TGFB1/TGFB2/PGF/MDK 6 GO:0031279 regulation of cyclase activity 4/852 53/18722 0.22063165412078 0.459048828106609 TIMP2/GUCA2A/EDNRB/MAPK3 4 GO:0043113 receptor clustering 4/852 53/18722 0.22063165412078 0.459048828106609 PTN/APOE/FLNA/GSN 4 GO:0010675 regulation of cellular carbohydrate metabolic process 9/852 146/18722 0.221216820738528 0.459449641104044 IGF2/POMC/PTK2B/FAM3C/INSR/SCARB2/PPP1CB/TP53/DDB1 9 GO:0033138 positive regulation of peptidyl-serine phosphorylation 7/852 108/18722 0.221302872834532 0.459449641104044 TGFB1/SMYD3/PINK1/TXN/MIF/BCAR3/SH2D3A 7 GO:0002228 natural killer cell mediated immunity 5/852 71/18722 0.221372020599505 0.459449641104044 HLA-G/PVR/LAMP1/ARL8B/AP1G1 5 GO:0032722 positive regulation of chemokine production 5/852 71/18722 0.221372020599505 0.459449641104044 LPL/CSF1R/EGR1/LRP1/ADAM17 5 GO:0061515 myeloid cell development 5/852 71/18722 0.221372020599505 0.459449641104044 FBN1/CITED2/PTBP3/NOTCH2/ATP6AP1 5 GO:0072078 nephron tubule morphogenesis 5/852 71/18722 0.221372020599505 0.459449641104044 NOG/GATA3/CTNNB1/LAMA5/MAGED1 5 GO:0048565 digestive tract development 8/852 127/18722 0.2218667813615 0.460286690268933 IL6ST/SFRP1/SMAD3/TGFB2/EDNRB/CTNNB1/KLF5/YIPF6 8 GO:0010923 negative regulation of phosphatase activity 3/852 36/18722 0.224197480339279 0.463212610241212 MGAT5/TGFB2/LGALS3 3 GO:0014741 negative regulation of muscle hypertrophy 3/852 36/18722 0.224197480339279 0.463212610241212 SMAD3/P2RX4/ERRFI1 3 GO:0030224 monocyte differentiation 3/852 36/18722 0.224197480339279 0.463212610241212 CSF1R/MYH9/ZFP36L1 3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/852 36/18722 0.224197480339279 0.463212610241212 CAMK2N1/LRP1/SRI 3 GO:0044060 regulation of endocrine process 3/852 36/18722 0.224197480339279 0.463212610241212 POMC/INHA/RAB8B 3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 3/852 36/18722 0.224197480339279 0.463212610241212 HIP1/BCAR3/ADAM17 3 GO:0060251 regulation of glial cell proliferation 3/852 36/18722 0.224197480339279 0.463212610241212 ASCL2/PTN/TSPO 3 GO:0060338 regulation of type I interferon-mediated signaling pathway 3/852 36/18722 0.224197480339279 0.463212610241212 ISG15/STAT2/UBE2K 3 GO:1903539 protein localization to postsynaptic membrane 3/852 36/18722 0.224197480339279 0.463212610241212 GPC4/ADAM10/DAG1 3 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 3/852 36/18722 0.224197480339279 0.463212610241212 RHOU/PINK1/SH3GLB1 3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 6/852 90/18722 0.226195222114271 0.466765294342406 PLK2/GBA/ANKIB1/HERPUD1/RNF144B/CSNK1A1 6 GO:0042475 odontogenesis of dentin-containing tooth 6/852 90/18722 0.226195222114271 0.466765294342406 HTRA1/SERPINE1/ADM/CTNNB1/LAMA5/BSG 6 GO:0048477 oogenesis 6/852 90/18722 0.226195222114271 0.466765294342406 HEXB/PTN/PTK2B/CTNNB1/PAQR7/MDK 6 GO:0006814 sodium ion transport 14/852 245/18722 0.227374726451912 0.467967140846644 SERPINE2/PRSS8/SLC4A7/SLC6A2/FXYD5/SLC23A2/GLRX/PKP2/SLC38A10/DNM2/ACTN4/SLC6A8/P2RX4/PTPN3 14 GO:0001707 mesoderm formation 5/852 72/18722 0.22975010903254 0.467967140846644 NOG/ITGB1/SMAD3/BMPR2/EXT2 5 GO:0014743 regulation of muscle hypertrophy 5/852 72/18722 0.22975010903254 0.467967140846644 IL6ST/SMAD3/PPP3CA/P2RX4/ERRFI1 5 GO:0043903 regulation of biological process involved in symbiotic interaction 5/852 72/18722 0.22975010903254 0.467967140846644 P4HB/CAV2/FUCA2/DDB1/GSN 5 GO:0050709 negative regulation of protein secretion 5/852 72/18722 0.22975010903254 0.467967140846644 SFRP1/APOE/PPP3CA/ERP29/FRMD4A 5 GO:0070227 lymphocyte apoptotic process 5/852 72/18722 0.22975010903254 0.467967140846644 EFNA1/PKN1/LGALS3/KDELR1/TP53 5 GO:0071479 cellular response to ionizing radiation 5/852 72/18722 0.22975010903254 0.467967140846644 SFRP1/GATA3/DNM2/EGR1/TP53 5 GO:0003159 morphogenesis of an endothelium 2/852 20/18722 0.230361449205535 0.467967140846644 ACVRL1/CTNNB1 2 GO:0006346 DNA methylation-dependent heterochromatin assembly 2/852 20/18722 0.230361449205535 0.467967140846644 MBD2/MBD3 2 GO:0007620 copulation 2/852 20/18722 0.230361449205535 0.467967140846644 SERPINE2/EDNRB 2 GO:0009713 catechol-containing compound biosynthetic process 2/852 20/18722 0.230361449205535 0.467967140846644 GATA3/TGFB2 2 GO:0010042 response to manganese ion 2/852 20/18722 0.230361449205535 0.467967140846644 TSPO/ADAM9 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/852 20/18722 0.230361449205535 0.467967140846644 TMBIM6/SRI 2 GO:0032332 positive regulation of chondrocyte differentiation 2/852 20/18722 0.230361449205535 0.467967140846644 ACVRL1/SMAD3 2 GO:0032495 response to muramyl dipeptide 2/852 20/18722 0.230361449205535 0.467967140846644 TNFAIP3/ARHGEF2 2 GO:0042423 catecholamine biosynthetic process 2/852 20/18722 0.230361449205535 0.467967140846644 GATA3/TGFB2 2 GO:0045844 positive regulation of striated muscle tissue development 2/852 20/18722 0.230361449205535 0.467967140846644 IGF2/CTNNB1 2 GO:0046931 pore complex assembly 2/852 20/18722 0.230361449205535 0.467967140846644 ADAM10/RTN4 2 GO:0048636 positive regulation of muscle organ development 2/852 20/18722 0.230361449205535 0.467967140846644 IGF2/CTNNB1 2 GO:0060044 negative regulation of cardiac muscle cell proliferation 2/852 20/18722 0.230361449205535 0.467967140846644 NOG/CITED2 2 GO:0060231 mesenchymal to epithelial transition 2/852 20/18722 0.230361449205535 0.467967140846644 GATA3/CTNNB1 2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 2/852 20/18722 0.230361449205535 0.467967140846644 ISG15/STAT2 2 GO:0061154 endothelial tube morphogenesis 2/852 20/18722 0.230361449205535 0.467967140846644 ACVRL1/CTNNB1 2 GO:0071243 cellular response to arsenic-containing substance 2/852 20/18722 0.230361449205535 0.467967140846644 ATF3/ATF4 2 GO:0071397 cellular response to cholesterol 2/852 20/18722 0.230361449205535 0.467967140846644 ABCA1/DAG1 2 GO:0071731 response to nitric oxide 2/852 20/18722 0.230361449205535 0.467967140846644 DNM2/TXN 2 GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/852 20/18722 0.230361449205535 0.467967140846644 LPL/LRP1 2 GO:0097320 plasma membrane tubulation 2/852 20/18722 0.230361449205535 0.467967140846644 DNM2/SH3GLB1 2 GO:1901386 negative regulation of voltage-gated calcium channel activity 2/852 20/18722 0.230361449205535 0.467967140846644 RRAD/FMR1 2 GO:1902004 positive regulation of amyloid-beta formation 2/852 20/18722 0.230361449205535 0.467967140846644 EFNA1/PICALM 2 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/852 20/18722 0.230361449205535 0.467967140846644 HSPB1/PINK1 2 GO:1904292 regulation of ERAD pathway 2/852 20/18722 0.230361449205535 0.467967140846644 HERPUD1/TMEM259 2 GO:1990182 exosomal secretion 2/852 20/18722 0.230361449205535 0.467967140846644 SDC4/SDC1 2 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/852 20/18722 0.230361449205535 0.467967140846644 LPL/LRP1 2 GO:0006584 catecholamine metabolic process 4/852 54/18722 0.230427195046452 0.467967140846644 EPAS1/GATA3/MAOA/TGFB2 4 GO:0006968 cellular defense response 4/852 54/18722 0.230427195046452 0.467967140846644 HLA-G/LGALS3BP/ITGB1/PTK2B 4 GO:0009712 catechol-containing compound metabolic process 4/852 54/18722 0.230427195046452 0.467967140846644 EPAS1/GATA3/MAOA/TGFB2 4 GO:0014888 striated muscle adaptation 4/852 54/18722 0.230427195046452 0.467967140846644 SMAD3/PPP3CA/GSN/ERRFI1 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/852 54/18722 0.230427195046452 0.467967140846644 FLNA/CTNNB1/CTSZ/MDK 4 GO:0034767 positive regulation of ion transmembrane transport 10/852 167/18722 0.230496829358003 0.467967140846644 ITGB1/EPHB2/KCNJ2/FLNA/GLRX/IFNGR2/DNM2/PINK1/ACTN4/SRI 10 GO:0050905 neuromuscular process 9/852 148/18722 0.232694509785488 0.472238495060629 HEXB/KCNJ2/HERC1/GAA/GM2A/GBA/C12orf57/RBFOX2/SLC1A3 9 GO:0061136 regulation of proteasomal protein catabolic process 11/852 187/18722 0.232979329434171 0.472625943185079 APOE/PLK2/GBA/PINK1/ANKIB1/HERPUD1/RNF144B/CSNK1A1/UBE2K/FMR1/TMEM259 11 GO:0002065 columnar/cuboidal epithelial cell differentiation 6/852 91/18722 0.233654660956097 0.473614139585999 SERPINE1/IL6ST/SOX4/KLF5/RHEB/YIPF6 6 GO:0019935 cyclic-nucleotide-mediated signaling 6/852 91/18722 0.233654660956097 0.473614139585999 ADM/POMC/PTK2B/APOE/EDNRB/EIF4EBP2 6 GO:0003014 renal system process 7/852 110/18722 0.234765112514322 0.475099642655642 MCAM/ADM/EDNRB/PKN1/WFS1/GJA5/GSN 7 GO:0032611 interleukin-1 beta production 7/852 110/18722 0.234765112514322 0.475099642655642 LPL/SMAD3/HSPB1/TNFAIP3/EGR1/NLRP2/ERRFI1 7 GO:0032651 regulation of interleukin-1 beta production 7/852 110/18722 0.234765112514322 0.475099642655642 LPL/SMAD3/HSPB1/TNFAIP3/EGR1/NLRP2/ERRFI1 7 GO:0090174 organelle membrane fusion 7/852 110/18722 0.234765112514322 0.475099642655642 RAB8B/SNAP23/CAV2/USO1/ARL8B/SEC22B/YIPF5 7 GO:0002831 regulation of response to biotic stimulus 18/852 327/18722 0.235364317906083 0.47609382593754 HTRA1/HLA-G/SERPING1/PVR/APOE/GRN/ISG15/TNFAIP3/SASH1/STAT2/LAMP1/MAPK3/ERAP1/AP1G1/XIAP/SEC14L1/UBE2K/PCBP2 18 GO:0046777 protein autophosphorylation 13/852 227/18722 0.235697990653419 0.47609382593754 FLT1/ENG/FGFR1/ERBB2/PTK2B/CSF1R/INSR/DAPK1/PINK1/PTK2/MAPK3/IQGAP1/ERRFI1 13 GO:0016482 cytosolic transport 10/852 168/18722 0.23593399880737 0.47609382593754 FLNA/WIPI1/LAMP1/CLN5/TBC1D10A/MAPK3/RHOBTB3/ARL8B/AP1G1/EZR 10 GO:0003161 cardiac conduction system development 3/852 37/18722 0.236391510236025 0.47609382593754 NOTCH2/DSG2/GJA5 3 GO:0034260 negative regulation of GTPase activity 3/852 37/18722 0.236391510236025 0.47609382593754 F11R/TMED2/SH3BP4 3 GO:0043687 post-translational protein modification 3/852 37/18722 0.236391510236025 0.47609382593754 P3H1/STT3A/STT3B 3 GO:0050775 positive regulation of dendrite morphogenesis 3/852 37/18722 0.236391510236025 0.47609382593754 TIAM1/CUX1/OBSL1 3 GO:0060306 regulation of membrane repolarization 3/852 37/18722 0.236391510236025 0.47609382593754 KCNJ2/FLNA/GJA5 3 GO:0062237 protein localization to postsynapse 3/852 37/18722 0.236391510236025 0.47609382593754 GPC4/ADAM10/DAG1 3 GO:0071542 dopaminergic neuron differentiation 3/852 37/18722 0.236391510236025 0.47609382593754 SFRP1/TIAM1/CTNNB1 3 GO:1900016 negative regulation of cytokine production involved in inflammatory response 3/852 37/18722 0.236391510236025 0.47609382593754 IL1R2/ADCY7/CHID1 3 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 3/852 37/18722 0.236391510236025 0.47609382593754 TNKS2/CTNNB1/MAPK3 3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 5/852 73/18722 0.238218148618472 0.478814673321394 HMGN3/CAMK2N1/TIAM1/LRP1/SRI 5 GO:0043299 leukocyte degranulation 5/852 73/18722 0.238218148618472 0.478814673321394 GATA2/SNAP23/LAMP1/S100A13/AP1G1 5 GO:0051865 protein autoubiquitination 5/852 73/18722 0.238218148618472 0.478814673321394 SASH1/LTN1/RNF13/AMFR/UBE2A 5 GO:0072088 nephron epithelium morphogenesis 5/852 73/18722 0.238218148618472 0.478814673321394 NOG/GATA3/CTNNB1/LAMA5/MAGED1 5 GO:0072089 stem cell proliferation 5/852 73/18722 0.238218148618472 0.478814673321394 FBLN1/LTBP3/GBA/ZFP36L1/CCNE1 5 GO:0038066 p38MAPK cascade 4/852 55/18722 0.240327804164661 0.482092402694595 SASH1/ZFP36L1/EZR/EMC10 4 GO:0042220 response to cocaine 4/852 55/18722 0.240327804164661 0.482092402694595 PTK2B/TIAM1/DNM2/SLC1A3 4 GO:0045620 negative regulation of lymphocyte differentiation 4/852 55/18722 0.240327804164661 0.482092402694595 SFRP1/ERBB2/INHA/MDK 4 GO:0051898 negative regulation of protein kinase B signaling 4/852 55/18722 0.240327804164661 0.482092402694595 HLA-G/DAG1/PLEKHA1/PIK3CB 4 GO:0061098 positive regulation of protein tyrosine kinase activity 4/852 55/18722 0.240327804164661 0.482092402694595 CSF1R/EFNA1/ERBB3/ADAM17 4 GO:0031058 positive regulation of histone modification 6/852 92/18722 0.241189375480383 0.483627938961262 GATA3/CTNNB1/PINK1/MAPK3/TP53/FMR1 6 GO:0015718 monocarboxylic acid transport 7/852 111/18722 0.241595853954269 0.483864676861056 PTGES/SLCO2A1/SLC16A3/SLC16A4/SLC6A8/P2RX4/SLC16A1 7 GO:0071867 response to monoamine 7/852 111/18722 0.241595853954269 0.483864676861056 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0071869 response to catecholamine 7/852 111/18722 0.241595853954269 0.483864676861056 FLNA/DNM2/CAV2/MAPK3/NCSTN/ID1/ATF4 7 GO:0006631 fatty acid metabolic process 21/852 390/18722 0.243447749778099 0.48737968362497 HPGD/PTGES/PRKAG2/PAM/APOC1/LPL/MFSD2A/XBP1/FADS3/INSIG1/TECR/ACOX1/MGLL/LIPG/FABP5/ACSL4/MIF/MAPK3/GPX4/LYPLA1/ACSL3 21 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 12/852 209/18722 0.244503320808421 0.487798153000718 TNFSF10/EGLN3/SMAD3/HIP1/RPS27L/DAP/DAPK1/NLRP2/HERPUD1/CTSH/XIAP/GSN 12 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 5/852 74/18722 0.24677019202892 0.487798153000718 SFRP1/NCOR2/PKN1/CALR/CARM1 5 GO:0048332 mesoderm morphogenesis 5/852 74/18722 0.24677019202892 0.487798153000718 NOG/ITGB1/SMAD3/BMPR2/EXT2 5 GO:1901568 fatty acid derivative metabolic process 5/852 74/18722 0.24677019202892 0.487798153000718 HPGD/PAM/TECR/ACSL4/ACSL3 5 GO:0001502 cartilage condensation 2/852 21/18722 0.247464929602229 0.487798153000718 BMP1/MYCN 2 GO:0002689 negative regulation of leukocyte chemotaxis 2/852 21/18722 0.247464929602229 0.487798153000718 MIF/DPP4 2 GO:0006925 inflammatory cell apoptotic process 2/852 21/18722 0.247464929602229 0.487798153000718 CTSL/PIK3CB 2 GO:0007617 mating behavior 2/852 21/18722 0.247464929602229 0.487798153000718 HEXB/NCOA1 2 GO:0009067 aspartate family amino acid biosynthetic process 2/852 21/18722 0.247464929602229 0.487798153000718 PLOD3/PLOD2 2 GO:0022010 central nervous system myelination 2/852 21/18722 0.247464929602229 0.487798153000718 B4GALT5/NCSTN 2 GO:0030449 regulation of complement activation 2/852 21/18722 0.247464929602229 0.487798153000718 SERPING1/CD59 2 GO:0032288 myelin assembly 2/852 21/18722 0.247464929602229 0.487798153000718 CD9/GPC1 2 GO:0032291 axon ensheathment in central nervous system 2/852 21/18722 0.247464929602229 0.487798153000718 B4GALT5/NCSTN 2 GO:0032303 regulation of icosanoid secretion 2/852 21/18722 0.247464929602229 0.487798153000718 PTGES/P2RX4 2 GO:0032516 positive regulation of phosphoprotein phosphatase activity 2/852 21/18722 0.247464929602229 0.487798153000718 ITGA1/PPP1R15B 2 GO:0033630 positive regulation of cell adhesion mediated by integrin 2/852 21/18722 0.247464929602229 0.487798153000718 TGFB2/ADAM9 2 GO:0035020 regulation of Rac protein signal transduction 2/852 21/18722 0.247464929602229 0.487798153000718 DNM2/PIK3CB 2 GO:0044241 lipid digestion 2/852 21/18722 0.247464929602229 0.487798153000718 LIMA1/LDLR 2 GO:0044342 type B pancreatic cell proliferation 2/852 21/18722 0.247464929602229 0.487798153000718 SFRP1/ERRFI1 2 GO:0045717 negative regulation of fatty acid biosynthetic process 2/852 21/18722 0.247464929602229 0.487798153000718 APOC1/INSIG1 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/852 21/18722 0.247464929602229 0.487798153000718 TXN/PKIG 2 GO:0050849 negative regulation of calcium-mediated signaling 2/852 21/18722 0.247464929602229 0.487798153000718 FHL2/RCAN1 2 GO:0060972 left/right pattern formation 2/852 21/18722 0.247464929602229 0.487798153000718 CITED2/NOTCH2 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/852 21/18722 0.247464929602229 0.487798153000718 HLA-G/SEMA7A 2 GO:0072111 cell proliferation involved in kidney development 2/852 21/18722 0.247464929602229 0.487798153000718 GATA3/EGR1 2 GO:0072243 metanephric nephron epithelium development 2/852 21/18722 0.247464929602229 0.487798153000718 WWTR1/LAMB2 2 GO:0090141 positive regulation of mitochondrial fission 2/852 21/18722 0.247464929602229 0.487798153000718 RALBP1/PINK1 2 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 2/852 21/18722 0.247464929602229 0.487798153000718 NOG/MAGED1 2 GO:0097734 extracellular exosome biogenesis 2/852 21/18722 0.247464929602229 0.487798153000718 SDC4/SDC1 2 GO:0098698 postsynaptic specialization assembly 2/852 21/18722 0.247464929602229 0.487798153000718 IL1RAP/PTPRS 2 GO:1901863 positive regulation of muscle tissue development 2/852 21/18722 0.247464929602229 0.487798153000718 IGF2/CTNNB1 2 GO:1902644 tertiary alcohol metabolic process 2/852 21/18722 0.247464929602229 0.487798153000718 CYP11A1/H6PD 2 GO:1905209 positive regulation of cardiocyte differentiation 2/852 21/18722 0.247464929602229 0.487798153000718 TGFB1/TGFB2 2 GO:2000774 positive regulation of cellular senescence 2/852 21/18722 0.247464929602229 0.487798153000718 HLA-G/YPEL3 2 GO:2001014 regulation of skeletal muscle cell differentiation 2/852 21/18722 0.247464929602229 0.487798153000718 GPC1/DDX17 2 GO:0035601 protein deacylation 7/852 112/18722 0.248489063407384 0.487798153000718 NOTUM/FLNA/MORF4L2/HDAC5/PINK1/TP53/LYPLA1 7 GO:0046390 ribose phosphate biosynthetic process 11/852 190/18722 0.248568504374408 0.487798153000718 PRKAG2/TGFB1/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/PYGL/RFK/CMPK1/ACSL3 11 GO:0000578 embryonic axis specification 3/852 38/18722 0.248696614464503 0.487798153000718 PCSK6/TMED2/CTNNB1 3 GO:0001825 blastocyst formation 3/852 38/18722 0.248696614464503 0.487798153000718 CITED2/RTN4/FURIN 3 GO:0010742 macrophage derived foam cell differentiation 3/852 38/18722 0.248696614464503 0.487798153000718 LPL/TGFB1/ABCA1 3 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 3/852 38/18722 0.248696614464503 0.487798153000718 SFRP1/NCOR2/CALR 3 GO:0035136 forelimb morphogenesis 3/852 38/18722 0.248696614464503 0.487798153000718 CRABP2/CTNNB1/RDH10 3 GO:0035337 fatty-acyl-CoA metabolic process 3/852 38/18722 0.248696614464503 0.487798153000718 TECR/ACSL4/ACSL3 3 GO:0042596 fear response 3/852 38/18722 0.248696614464503 0.487798153000718 APOE/MDK/DPP4 3 GO:0046329 negative regulation of JNK cascade 3/852 38/18722 0.248696614464503 0.487798153000718 SFRP1/PINK1/HIPK3 3 GO:0046633 alpha-beta T cell proliferation 3/852 38/18722 0.248696614464503 0.487798153000718 EBI3/ELF4/CBLB 3 GO:0051930 regulation of sensory perception of pain 3/852 38/18722 0.248696614464503 0.487798153000718 EDNRB/MGLL/FABP5 3 GO:0071392 cellular response to estradiol stimulus 3/852 38/18722 0.248696614464503 0.487798153000718 NRIP1/SFRP1/ZNF703 3 GO:0071398 cellular response to fatty acid 3/852 38/18722 0.248696614464503 0.487798153000718 LPL/ID3/LDLR 3 GO:0090077 foam cell differentiation 3/852 38/18722 0.248696614464503 0.487798153000718 LPL/TGFB1/ABCA1 3 GO:0099622 cardiac muscle cell membrane repolarization 3/852 38/18722 0.248696614464503 0.487798153000718 KCNJ2/FLNA/GJA5 3 GO:2000279 negative regulation of DNA biosynthetic process 3/852 38/18722 0.248696614464503 0.487798153000718 ACVRL1/BMPR2/TP53 3 GO:0090398 cellular senescence 6/852 93/18722 0.248795299311795 0.487801613337072 HLA-G/NUAK1/PLK2/CALR/YPEL3/TP53 6 GO:0031396 regulation of protein ubiquitination 12/852 210/18722 0.249487617247205 0.488514985699566 TSPO/SOX4/ISG15/TNFAIP3/WFS1/SASH1/CBLB/PINK1/HERPUD1/NDFIP2/XIAP/NDFIP1 12 GO:0071333 cellular response to glucose stimulus 9/852 151/18722 0.250302803488172 0.488514985699566 HMGN3/CAMK2N1/SOX4/ENDOG/XBP1/TIAM1/LRP1/PPP3CA/SRI 9 GO:1904064 positive regulation of cation transmembrane transport 9/852 151/18722 0.250302803488172 0.488514985699566 EPHB2/KCNJ2/FLNA/GLRX/IFNGR2/DNM2/PINK1/ACTN4/SRI 9 GO:0001658 branching involved in ureteric bud morphogenesis 4/852 56/18722 0.250323891937052 0.488514985699566 NOG/CTNNB1/LAMA5/MAGED1 4 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 4/852 56/18722 0.250323891937052 0.488514985699566 HLA-G/PVR/LAMP1/AP1G1 4 GO:0002090 regulation of receptor internalization 4/852 56/18722 0.250323891937052 0.488514985699566 CD63/ANKRD13A/INSR/FMR1 4 GO:0002711 positive regulation of T cell mediated immunity 4/852 56/18722 0.250323891937052 0.488514985699566 HLA-G/IL1R1/GATA3/PVR 4 GO:0010518 positive regulation of phospholipase activity 4/852 56/18722 0.250323891937052 0.488514985699566 FLT1/FGFR1/ARF4/GNAQ 4 GO:0042733 embryonic digit morphogenesis 4/852 56/18722 0.250323891937052 0.488514985699566 NOG/GRHL2/CTNNB1/MYCN 4 GO:0043388 positive regulation of DNA binding 4/852 56/18722 0.250323891937052 0.488514985699566 GATA3/TGFB1/CTNNB1/TXN 4 GO:0051058 negative regulation of small GTPase mediated signal transduction 4/852 56/18722 0.250323891937052 0.488514985699566 TIMP2/ITGB1/TGFB2/EPHB2 4 GO:0071385 cellular response to glucocorticoid stimulus 4/852 56/18722 0.250323891937052 0.488514985699566 SMYD3/FBXO32/ZFP36L1/ERRFI1 4 GO:0042391 regulation of membrane potential 23/852 434/18722 0.254411983836047 0.496297009606118 PTN/CLDN19/TSPO/KCNK12/PYCR1/SLC39A8/PTK2B/KCNJ2/FLNA/GLRX/PKP2/GBA/DSG2/GJA5/PINK1/SH3GL1/PPP3CA/P2RX4/GNAQ/JUP/PTPN3/FMR1/SRI 23 GO:0042180 cellular ketone metabolic process 12/852 211/18722 0.254508758552233 0.496297009606118 ADM/PRKAG2/APOC1/MFSD2A/INSIG1/CYP11A1/NCOR2/H6PD/FABP5/EGR1/VKORC1/RDH10 12 GO:0048662 negative regulation of smooth muscle cell proliferation 5/852 75/18722 0.255400289803829 0.497538046858295 TPM1/IGFBP3/APOE/TNFAIP3/BMPR2 5 GO:0051453 regulation of intracellular pH 5/852 75/18722 0.255400289803829 0.497538046858295 SLC4A7/GRN/CLIC4/ATP6V0E1/CLN5 5 GO:0002708 positive regulation of lymphocyte mediated immunity 7/852 113/18722 0.255441747085602 0.497538046858295 HLA-G/IL1R1/GATA3/TGFB1/PVR/LAMP1/AP1G1 7 GO:0001738 morphogenesis of a polarized epithelium 6/852 94/18722 0.256468344115438 0.499344362063056 SFRP1/GPC4/ACTB/FAT1/TIAM1/LAMA5 6 GO:0001678 cellular glucose homeostasis 10/852 172/18722 0.258138516655502 0.502401838486907 HMGN3/CAMK2N1/SOX4/ENDOG/XBP1/TIAM1/LRP1/PPP3CA/PIK3R1/SRI 10 GO:0046887 positive regulation of hormone secretion 8/852 133/18722 0.259661599252643 0.504837411878009 TCF7L2/CAMK2N1/INHA/SOX4/RAB8B/ACSL4/LRP1/SRI 8 GO:0051155 positive regulation of striated muscle cell differentiation 4/852 57/18722 0.260405966648608 0.504837411878009 TGFB1/ATP11A/MORF4L2/MMP14 4 GO:0051289 protein homotetramerization 4/852 57/18722 0.260405966648608 0.504837411878009 KCNJ2/VASP/GLS/EVL 4 GO:0097120 receptor localization to synapse 4/852 57/18722 0.260405966648608 0.504837411878009 GPC4/ADAM10/DAG1/NPTN 4 GO:0001941 postsynaptic membrane organization 3/852 39/18722 0.261095128773784 0.504837411878009 PTN/APOE/EPHB2 3 GO:0002347 response to tumor cell 3/852 39/18722 0.261095128773784 0.504837411878009 ADAM15/PVR/DAPK1 3 GO:0010463 mesenchymal cell proliferation 3/852 39/18722 0.261095128773784 0.504837411878009 PTN/CTNNB1/MYCN 3 GO:0016572 histone phosphorylation 3/852 39/18722 0.261095128773784 0.504837411878009 PKN1/MAPK3/FMR1 3 GO:0021587 cerebellum morphogenesis 3/852 39/18722 0.261095128773784 0.504837411878009 SERPINE2/HERC1/GBA 3 GO:0045823 positive regulation of heart contraction 3/852 39/18722 0.261095128773784 0.504837411878009 TPM1/ADM/TGFB2 3 GO:0046326 positive regulation of glucose import 3/852 39/18722 0.261095128773784 0.504837411878009 INSR/OPN3/PIK3R1 3 GO:0046461 neutral lipid catabolic process 3/852 39/18722 0.261095128773784 0.504837411878009 LPL/MGLL/LIPG 3 GO:0046464 acylglycerol catabolic process 3/852 39/18722 0.261095128773784 0.504837411878009 LPL/MGLL/LIPG 3 GO:0046621 negative regulation of organ growth 3/852 39/18722 0.261095128773784 0.504837411878009 NOG/CITED2/WWC3 3 GO:0051084 'de novo' posttranslational protein folding 3/852 39/18722 0.261095128773784 0.504837411878009 ERO1A/HSPH1/SDF2L1 3 GO:0051931 regulation of sensory perception 3/852 39/18722 0.261095128773784 0.504837411878009 EDNRB/MGLL/FABP5 3 GO:2000785 regulation of autophagosome assembly 3/852 39/18722 0.261095128773784 0.504837411878009 PINK1/SEC22B/SH3GLB1 3 GO:0071331 cellular response to hexose stimulus 9/852 153/18722 0.262281781396794 0.506761289082524 HMGN3/CAMK2N1/SOX4/ENDOG/XBP1/TIAM1/LRP1/PPP3CA/SRI 9 GO:0001937 negative regulation of endothelial cell proliferation 5/852 76/18722 0.264102501864904 0.506761289082524 FLT1/SPARC/ACVRL1/APOE/CAV2 5 GO:0021536 diencephalon development 5/852 76/18722 0.264102501864904 0.506761289082524 NOG/PTN/SEMA5A/GATA2/NCOA1 5 GO:0031100 animal organ regeneration 5/852 76/18722 0.264102501864904 0.506761289082524 ADM/PGF/IGF2R/PTPN3/TGFBR3 5 GO:0072028 nephron morphogenesis 5/852 76/18722 0.264102501864904 0.506761289082524 NOG/GATA3/CTNNB1/LAMA5/MAGED1 5 GO:0008585 female gonad development 6/852 95/18722 0.264204406400344 0.506761289082524 NRIP1/SFRP1/ADAMTS1/INHA/MMP14/PLEKHA1 6 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 2/852 22/18722 0.264607325195484 0.506761289082524 ADM/DNM2 2 GO:0002053 positive regulation of mesenchymal cell proliferation 2/852 22/18722 0.264607325195484 0.506761289082524 CTNNB1/MYCN 2 GO:0002320 lymphoid progenitor cell differentiation 2/852 22/18722 0.264607325195484 0.506761289082524 GATA3/SOX4 2 GO:0006662 glycerol ether metabolic process 2/852 22/18722 0.264607325195484 0.506761289082524 PLA2G7/TXN 2 GO:0007398 ectoderm development 2/852 22/18722 0.264607325195484 0.506761289082524 CTNNB1/ETS2 2 GO:0008211 glucocorticoid metabolic process 2/852 22/18722 0.264607325195484 0.506761289082524 CYP11A1/H6PD 2 GO:0016137 glycoside metabolic process 2/852 22/18722 0.264607325195484 0.506761289082524 GBA/FUCA2 2 GO:0022401 negative adaptation of signaling pathway 2/852 22/18722 0.264607325195484 0.506761289082524 ADM/DNM2 2 GO:0032098 regulation of appetite 2/852 22/18722 0.264607325195484 0.506761289082524 POMC/NUCB2 2 GO:0032816 positive regulation of natural killer cell activation 2/852 22/18722 0.264607325195484 0.506761289082524 LAMP1/AP1G1 2 GO:0034629 cellular protein-containing complex localization 2/852 22/18722 0.264607325195484 0.506761289082524 TNFAIP2/EZR 2 GO:0035809 regulation of urine volume 2/852 22/18722 0.264607325195484 0.506761289082524 ADM/EDNRB 2 GO:0036120 cellular response to platelet-derived growth factor stimulus 2/852 22/18722 0.264607325195484 0.506761289082524 PTN/ERRFI1 2 GO:0044346 fibroblast apoptotic process 2/852 22/18722 0.264607325195484 0.506761289082524 SFRP1/TP53 2 GO:0048169 regulation of long-term neuronal synaptic plasticity 2/852 22/18722 0.264607325195484 0.506761289082524 EPHB2/NPTN 2 GO:0051220 cytoplasmic sequestering of protein 2/852 22/18722 0.264607325195484 0.506761289082524 FLNA/SRI 2 GO:0051412 response to corticosterone 2/852 22/18722 0.264607325195484 0.506761289082524 HSD3B1/FOSB 2 GO:0060563 neuroepithelial cell differentiation 2/852 22/18722 0.264607325195484 0.506761289082524 SERPINE1/SOX4 2 GO:2000193 positive regulation of fatty acid transport 2/852 22/18722 0.264607325195484 0.506761289082524 PTGES/P2RX4 2 GO:0032147 activation of protein kinase activity 8/852 134/18722 0.266146069633549 0.509514328058446 PRKAG2/GPRC5A/TGFB2/PTK2B/INSR/PINK1/TXN/PRRC1 8 GO:0071326 cellular response to monosaccharide stimulus 9/852 154/18722 0.268337762359205 0.51351481291022 HMGN3/CAMK2N1/SOX4/ENDOG/XBP1/TIAM1/LRP1/PPP3CA/SRI 9 GO:0043279 response to alkaloid 7/852 115/18722 0.269513456178057 0.515372805829848 PTK2B/PEA15/TIAM1/DNM2/TMED10/FOSB/SLC1A3 7 GO:0090630 activation of GTPase activity 7/852 115/18722 0.269513456178057 0.515372805829848 SYDE1/PTK2B/ARHGEF16/TIAM1/TBC1D10A/ARHGAP29/SGSM3 7 GO:0006826 iron ion transport 4/852 58/18722 0.270564653964679 0.516990092408592 SLC39A8/DNM2/ARHGAP1/PGRMC2 4 GO:0097035 regulation of membrane lipid distribution 4/852 58/18722 0.270564653964679 0.516990092408592 ABCA7/MFSD2A/ATP11A/ABCA1 4 GO:1901655 cellular response to ketone 6/852 96/18722 0.271999374118264 0.519534288401223 SFRP1/ADAM15/SMYD3/FBXO32/GOLPH3/ERRFI1 6 GO:0050804 modulation of chemical synaptic transmission 23/852 439/18722 0.272108428988414 0.519545418474463 SERPINE2/ITGB1/PTN/PLCL2/RASGRF2/PTPRS/PTK2B/APOE/EPHB2/STXBP5/PLK2/DLGAP4/EIF4EBP2/PINK1/SH3GL1/DGKZ/YWHAG/PPP3CA/NPTN/SLC1A3/NCSTN/FMR1/ATF4 23 GO:0000380 alternative mRNA splicing, via spliceosome 5/852 77/18722 0.272870908484811 0.520361908061315 MBNL2/RBFOX2/SRSF6/FMR1/DDX17 5 GO:0032418 lysosome localization 5/852 77/18722 0.272870908484811 0.520361908061315 GATA2/SNAP23/MYH9/S100A13/ARL8B 5 GO:0051924 regulation of calcium ion transport 14/852 255/18722 0.273119043635979 0.520361908061315 RRAD/TSPO/PTK2B/SESTD1/CCR1/WFS1/CTNNB1/UBASH3B/LGALS3/P2RX4/TMBIM6/AHNAK/FMR1/SRI 14 GO:0055074 calcium ion homeostasis 24/852 460/18722 0.273292206144478 0.520361908061315 HEXB/ADM/GATA2/SMAD3/CAMK2N1/PTK2B/APOE/CCR1/EDNRB/WFS1/CALR/HSP90B1/UBASH3B/CAV2/LRP1/HERPUD1/ACKR2/ITPR2/P2RX4/NPTN/ERO1A/TMBIM6/TMCO1/SRI 24 GO:0010863 positive regulation of phospholipase C activity 3/852 40/18722 0.273569960009982 0.520361908061315 FLT1/FGFR1/GNAQ 3 GO:0032892 positive regulation of organic acid transport 3/852 40/18722 0.273569960009982 0.520361908061315 ITGB1/PTGES/P2RX4 3 GO:0045022 early endosome to late endosome transport 3/852 40/18722 0.273569960009982 0.520361908061315 FLNA/MAPK3/EZR 3 GO:0046365 monosaccharide catabolic process 3/852 40/18722 0.273569960009982 0.520361908061315 TP53/GLB1/GALE 3 GO:0072210 metanephric nephron development 3/852 40/18722 0.273569960009982 0.520361908061315 LAMB2/CTNNB1/EGR1 3 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 3/852 40/18722 0.273569960009982 0.520361908061315 RRAD/FMR1/SRI 3 GO:2000116 regulation of cysteine-type endopeptidase activity 13/852 235/18722 0.274171360686993 0.521308824456983 TNFSF10/EGLN3/SMAD3/HIP1/RPS27L/DAP/DAPK1/TBC1D10A/NLRP2/HERPUD1/CTSH/XIAP/GSN 13 GO:0051147 regulation of muscle cell differentiation 9/852 155/18722 0.274435566666087 0.521614126522061 IGF2/ENG/TGFB1/ATP11A/XBP1/MORF4L2/MMP14/BMPR2/HDAC5 9 GO:0050954 sensory perception of mechanical stimulus 10/852 175/18722 0.275228614448623 0.522923977546214 SERPINE2/HEXB/NAV2/WFS1/SCARB2/MYO6/P2RX4/SLC1A3/SERPINB6/EPS8L2 10 GO:0070302 regulation of stress-activated protein kinase signaling cascade 11/852 195/18722 0.275335178892755 0.522929039761221 SFRP1/TGFB2/PTK2B/SEMA4C/SASH1/PINK1/MAPK3/RNF13/HIPK3/EZR/EMC10 11 GO:0030518 intracellular steroid hormone receptor signaling pathway 7/852 116/18722 0.276626400844401 0.524985171738262 SFRP1/NCOR2/PKN1/CALR/CARM1/RBFOX2/DDX17 7 GO:0098732 macromolecule deacylation 7/852 116/18722 0.276626400844401 0.524985171738262 NOTUM/FLNA/MORF4L2/HDAC5/PINK1/TP53/LYPLA1 7 GO:0030900 forebrain development 20/852 379/18722 0.279064348165497 0.528530132213836 NOG/PTN/HSD3B1/SEMA5A/GATA2/PTPRS/MFSD2A/EPHB2/FLNA/SRGAP2C/SRGAP2/CTNNB1/RTN4/NCOA1/C12orf57/LRP1/SEMA7A/SUN2/MDK/TACC1 20 GO:0030072 peptide hormone secretion 13/852 236/18722 0.279123062736397 0.528530132213836 SFRP1/TCF7L2/HMGN3/CAMK2N1/SOX4/RAB8B/TIAM1/ACSL4/LRP1/PPP3CA/SLC16A1/SRI/DPP4 13 GO:1900180 regulation of protein localization to nucleus 8/852 136/18722 0.279252901115324 0.528530132213836 SMAD3/WWTR1/TGFB1/FLNA/PKIG/MAGED1/JUP/PIK3R1 8 GO:0035335 peptidyl-tyrosine dephosphorylation 6/852 97/18722 0.279849133050515 0.528530132213836 PTPRF/PTPRS/UBASH3B/SSH2/PTPN3/PTP4A1 6 GO:0006767 water-soluble vitamin metabolic process 4/852 59/18722 0.280790714876245 0.528530132213836 SLC23A2/CD320/LMBRD1/RFK 4 GO:0033013 tetrapyrrole metabolic process 4/852 59/18722 0.280790714876245 0.528530132213836 TSPO/CD320/PGRMC1/LMBRD1 4 GO:0048278 vesicle docking 4/852 59/18722 0.280790714876245 0.528530132213836 RAB8B/CTBP2/CAV2/USO1 4 GO:0051055 negative regulation of lipid biosynthetic process 4/852 59/18722 0.280790714876245 0.528530132213836 APOC1/LPCAT1/APOE/INSIG1 4 GO:2001258 negative regulation of cation channel activity 4/852 59/18722 0.280790714876245 0.528530132213836 RRAD/EPHB2/FMR1/SRI 4 GO:0043537 negative regulation of blood vessel endothelial cell migration 5/852 78/18722 0.28169962070971 0.528530132213836 ACVRL1/TGFB1/APOE/HDAC5/JUP 5 GO:1901616 organic hydroxy compound catabolic process 5/852 78/18722 0.28169962070971 0.528530132213836 DIO2/MAOA/APOE/SCARB1/IMPA2 5 GO:0006541 glutamine metabolic process 2/852 23/18722 0.281749720788739 0.528530132213836 GFPT1/GLS 2 GO:0006622 protein targeting to lysosome 2/852 23/18722 0.281749720788739 0.528530132213836 SCARB2/LAMP2 2 GO:0006929 substrate-dependent cell migration 2/852 23/18722 0.281749720788739 0.528530132213836 FN1/CTTN 2 GO:0023058 adaptation of signaling pathway 2/852 23/18722 0.281749720788739 0.528530132213836 ADM/DNM2 2 GO:0033081 regulation of T cell differentiation in thymus 2/852 23/18722 0.281749720788739 0.528530132213836 ERBB2/CLPTM1 2 GO:0034695 response to prostaglandin E 2/852 23/18722 0.281749720788739 0.528530132213836 SFRP1/TGFBR3 2 GO:0035640 exploration behavior 2/852 23/18722 0.281749720788739 0.528530132213836 APOE/DPP4 2 GO:0035988 chondrocyte proliferation 2/852 23/18722 0.281749720788739 0.528530132213836 MMP14/BMPR2 2 GO:0036119 response to platelet-derived growth factor 2/852 23/18722 0.281749720788739 0.528530132213836 PTN/ERRFI1 2 GO:0036303 lymph vessel morphogenesis 2/852 23/18722 0.281749720788739 0.528530132213836 ACVRL1/BMPR2 2 GO:0042438 melanin biosynthetic process 2/852 23/18722 0.281749720788739 0.528530132213836 OPN3/MFSD12 2 GO:0045662 negative regulation of myoblast differentiation 2/852 23/18722 0.281749720788739 0.528530132213836 TGFB1/ID3 2 GO:0045932 negative regulation of muscle contraction 2/852 23/18722 0.281749720788739 0.528530132213836 DOCK5/SRI 2 GO:0045943 positive regulation of transcription by RNA polymerase I 2/852 23/18722 0.281749720788739 0.528530132213836 ERBB2/ATF4 2 GO:0051349 positive regulation of lyase activity 2/852 23/18722 0.281749720788739 0.528530132213836 TIMP2/GUCA2A 2 GO:0071305 cellular response to vitamin D 2/852 23/18722 0.281749720788739 0.528530132213836 SFRP1/PTN 2 GO:0071636 positive regulation of transforming growth factor beta production 2/852 23/18722 0.281749720788739 0.528530132213836 SMAD3/FURIN 2 GO:0140112 extracellular vesicle biogenesis 2/852 23/18722 0.281749720788739 0.528530132213836 SDC4/SDC1 2 GO:1900273 positive regulation of long-term synaptic potentiation 2/852 23/18722 0.281749720788739 0.528530132213836 EPHB2/NPTN 2 GO:2000810 regulation of bicellular tight junction assembly 2/852 23/18722 0.281749720788739 0.528530132213836 F11R/MYO1C 2 GO:0002702 positive regulation of production of molecular mediator of immune response 7/852 117/18722 0.283786666440738 0.531954671209026 HLA-G/IL1R1/GATA3/TGFB1/EPHB2/XBP1/SEMA7A 7 GO:0072676 lymphocyte migration 7/852 117/18722 0.283786666440738 0.531954671209026 GATA3/F11R/JAM2/PTK2B/ADAM10/GBA/ADAM17 7 GO:0007586 digestion 8/852 137/18722 0.285870521429434 0.535103860349177 F11R/UGCG/SCARB1/LIMA1/LDLR/COPA/EZR/TJP2 8 GO:0010907 positive regulation of glucose metabolic process 3/852 41/18722 0.286104607232195 0.535103860349177 IGF2/INSR/DDB1 3 GO:0060612 adipose tissue development 3/852 41/18722 0.286104607232195 0.535103860349177 SH3PXD2B/XBP1/PGRMC2 3 GO:1902622 regulation of neutrophil migration 3/852 41/18722 0.286104607232195 0.535103860349177 IL1R1/MDK/DPP4 3 GO:1903524 positive regulation of blood circulation 3/852 41/18722 0.286104607232195 0.535103860349177 TPM1/ADM/TGFB2 3 GO:2000008 regulation of protein localization to cell surface 3/852 41/18722 0.286104607232195 0.535103860349177 ABCA7/CTNNB1/PICALM 3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 4/852 60/18722 0.291075062088485 0.543793907754768 TNFAIP3/SLC15A3/XIAP/SEC14L1 4 GO:0060038 cardiac muscle cell proliferation 4/852 60/18722 0.291075062088485 0.543793907754768 NOG/CITED2/TGFB2/TGFBR3 4 GO:1903670 regulation of sprouting angiogenesis 4/852 60/18722 0.291075062088485 0.543793907754768 ITGA5/JAK1/PIK3CB/EPN2 4 GO:0031341 regulation of cell killing 6/852 99/18722 0.295696593619899 0.552018158638336 HLA-G/DNASE1L3/PVR/CD59/LAMP1/AP1G1 6 GO:0051153 regulation of striated muscle cell differentiation 6/852 99/18722 0.295696593619899 0.552018158638336 TGFB1/ATP11A/XBP1/MORF4L2/MMP14/HDAC5 6 GO:0006913 nucleocytoplasmic transport 16/852 301/18722 0.297055455295747 0.552182651551294 TCF7L2/IFI27/SMAD3/TGFB1/FLNA/CALR/CBLB/TXN/PKIG/PPP3CA/XPOT/TP53/ZC3H11A/JUP/PIK3R1/IPO7 16 GO:0051169 nuclear transport 16/852 301/18722 0.297055455295747 0.552182651551294 TCF7L2/IFI27/SMAD3/TGFB1/FLNA/CALR/CBLB/TXN/PKIG/PPP3CA/XPOT/TP53/ZC3H11A/JUP/PIK3R1/IPO7 16 GO:0010906 regulation of glucose metabolic process 7/852 119/18722 0.298236909191536 0.552182651551294 IGF2/POMC/FAM3C/INSR/PPP1CB/TP53/DDB1 7 GO:0007212 dopamine receptor signaling pathway 3/852 42/18722 0.298683178082224 0.552182651551294 FLNA/CAV2/NCSTN 3 GO:0010591 regulation of lamellipodium assembly 3/852 42/18722 0.298683178082224 0.552182651551294 NCKAP1/DNM2/PIK3R1 3 GO:0010939 regulation of necrotic cell death 3/852 42/18722 0.298683178082224 0.552182651551294 TSPO/ARHGEF2/TP53 3 GO:0014003 oligodendrocyte development 3/852 42/18722 0.298683178082224 0.552182651551294 CD9/B4GALT5/NCSTN 3 GO:0021575 hindbrain morphogenesis 3/852 42/18722 0.298683178082224 0.552182651551294 SERPINE2/HERC1/GBA 3 GO:0030890 positive regulation of B cell proliferation 3/852 42/18722 0.298683178082224 0.552182651551294 EPHB2/CD320/MIF 3 GO:0032965 regulation of collagen biosynthetic process 3/852 42/18722 0.298683178082224 0.552182651551294 ENG/TGFB1/ERRFI1 3 GO:0033574 response to testosterone 3/852 42/18722 0.298683178082224 0.552182651551294 TSPO/CALR/GBA 3 GO:0043507 positive regulation of JUN kinase activity 3/852 42/18722 0.298683178082224 0.552182651551294 PTK2B/SASH1/TIAM1 3 GO:1900274 regulation of phospholipase C activity 3/852 42/18722 0.298683178082224 0.552182651551294 FLT1/FGFR1/GNAQ 3 GO:0002726 positive regulation of T cell cytokine production 2/852 24/18722 0.298856654644491 0.552182651551294 IL1R1/GATA3 2 GO:0006582 melanin metabolic process 2/852 24/18722 0.298856654644491 0.552182651551294 OPN3/MFSD12 2 GO:0021697 cerebellar cortex formation 2/852 24/18722 0.298856654644491 0.552182651551294 HERC1/GBA 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/852 24/18722 0.298856654644491 0.552182651551294 GUCA2A/PINK1 2 GO:0030878 thyroid gland development 2/852 24/18722 0.298856654644491 0.552182651551294 SMAD3/MAPK3 2 GO:0033032 regulation of myeloid cell apoptotic process 2/852 24/18722 0.298856654644491 0.552182651551294 PIK3CB/ADAM17 2 GO:0035458 cellular response to interferon-beta 2/852 24/18722 0.298856654644491 0.552182651551294 CAPN2/UBE2K 2 GO:0036010 protein localization to endosome 2/852 24/18722 0.298856654644491 0.552182651551294 ANKRD13A/EZR 2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 2/852 24/18722 0.298856654644491 0.552182651551294 GATA3/GPC1 2 GO:0044321 response to leptin 2/852 24/18722 0.298856654644491 0.552182651551294 EBI3/UGCG 2 GO:0050855 regulation of B cell receptor signaling pathway 2/852 24/18722 0.298856654644491 0.552182651551294 PLCL2/CMTM3 2 GO:0051156 glucose 6-phosphate metabolic process 2/852 24/18722 0.298856654644491 0.552182651551294 H6PD/TP53 2 GO:0060479 lung cell differentiation 2/852 24/18722 0.298856654644491 0.552182651551294 GRHL2/CTNNB1 2 GO:0098743 cell aggregation 2/852 24/18722 0.298856654644491 0.552182651551294 BMP1/MYCN 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/852 24/18722 0.298856654644491 0.552182651551294 GUCA2A/PINK1 2 GO:0021766 hippocampus development 5/852 80/18722 0.299514618735059 0.553195257282038 HSD3B1/PTPRS/MFSD2A/NCOA1/MDK 5 GO:0050994 regulation of lipid catabolic process 4/852 61/18722 0.301408774909858 0.556081511774675 APOC1/MFSD2A/SCARB1/LDLR 4 GO:0071384 cellular response to corticosteroid stimulus 4/852 61/18722 0.301408774909858 0.556081511774675 SMYD3/FBXO32/ZFP36L1/ERRFI1 4 GO:2000401 regulation of lymphocyte migration 4/852 61/18722 0.301408774909858 0.556081511774675 JAM2/PTK2B/ADAM10/ADAM17 4 GO:0099003 vesicle-mediated transport in synapse 11/852 200/18722 0.302943282676645 0.558707783697894 SYT8/STXBP5/ACTB/CANX/SNAP23/CTNNB1/DNM2/PICALM/CTBP2/SH3GL1/FMR1 11 GO:0046545 development of primary female sexual characteristics 6/852 100/18722 0.303686110364509 0.559872598338673 NRIP1/SFRP1/ADAMTS1/INHA/MMP14/PLEKHA1 6 GO:0006874 cellular calcium ion homeostasis 23/852 448/18722 0.305063159359793 0.56220537570774 HEXB/ADM/GATA2/SMAD3/PTK2B/APOE/CCR1/EDNRB/WFS1/CALR/HSP90B1/UBASH3B/CAV2/LRP1/HERPUD1/ACKR2/ITPR2/P2RX4/NPTN/ERO1A/TMBIM6/TMCO1/SRI 23 GO:0032411 positive regulation of transporter activity 7/852 120/18722 0.305520760079277 0.562842600834187 EPHB2/GLRX/IFNGR2/DNM2/PINK1/ACTN4/RXRA 7 GO:0031333 negative regulation of protein-containing complex assembly 8/852 140/18722 0.305951563309868 0.563223927629322 TMSB10/CAPG/MYADM/EIF4EBP1/GBA/SSH2/ARHGEF7/GSN 8 GO:0046165 alcohol biosynthetic process 8/852 140/18722 0.305951563309868 0.563223927629322 PTK2B/APOE/IPMK/INSIG1/H6PD/GBA/CYB5R3/IMPA2 8 GO:0001523 retinoid metabolic process 5/852 81/18722 0.308489366653516 0.567273285483064 TTR/CRABP2/DHRS3/LRP1/RDH10 5 GO:0051149 positive regulation of muscle cell differentiation 5/852 81/18722 0.308489366653516 0.567273285483064 ENG/TGFB1/ATP11A/MORF4L2/MMP14 5 GO:2000106 regulation of leukocyte apoptotic process 5/852 81/18722 0.308489366653516 0.567273285483064 EFNA1/PIK3CB/LGALS3/TP53/ADAM17 5 GO:0032640 tumor necrosis factor production 10/852 181/18722 0.310350359924551 0.569377505886039 TSPO/POMC/LPL/EPHB2/HSPB1/TNFAIP3/ARHGEF2/MIF/PIK3R1/ERRFI1 10 GO:0032680 regulation of tumor necrosis factor production 10/852 181/18722 0.310350359924551 0.569377505886039 TSPO/POMC/LPL/EPHB2/HSPB1/TNFAIP3/ARHGEF2/MIF/PIK3R1/ERRFI1 10 GO:0001504 neurotransmitter uptake 3/852 43/18722 0.311290400869602 0.569377505886039 ITGB1/SLC6A2/SLC1A3 3 GO:0006458 'de novo' protein folding 3/852 43/18722 0.311290400869602 0.569377505886039 ERO1A/HSPH1/SDF2L1 3 GO:0031952 regulation of protein autophosphorylation 3/852 43/18722 0.311290400869602 0.569377505886039 ENG/IQGAP1/ERRFI1 3 GO:0042088 T-helper 1 type immune response 3/852 43/18722 0.311290400869602 0.569377505886039 EBI3/IL1R1/IL18BP 3 GO:0042181 ketone biosynthetic process 3/852 43/18722 0.311290400869602 0.569377505886039 ADM/H6PD/EGR1 3 GO:0045776 negative regulation of blood pressure 3/852 43/18722 0.311290400869602 0.569377505886039 PRCP/BMPR2/GJA5 3 GO:0045981 positive regulation of nucleotide metabolic process 3/852 43/18722 0.311290400869602 0.569377505886039 GUCA2A/INSR/PINK1 3 GO:0098927 vesicle-mediated transport between endosomal compartments 3/852 43/18722 0.311290400869602 0.569377505886039 FLNA/MAPK3/EZR 3 GO:0140353 lipid export from cell 3/852 43/18722 0.311290400869602 0.569377505886039 PTGES/POMC/P2RX4 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/852 43/18722 0.311290400869602 0.569377505886039 GUCA2A/INSR/PINK1 3 GO:1901381 positive regulation of potassium ion transmembrane transport 3/852 43/18722 0.311290400869602 0.569377505886039 KCNJ2/FLNA/DNM2 3 GO:1903793 positive regulation of anion transport 3/852 43/18722 0.311290400869602 0.569377505886039 ITGB1/PTGES/P2RX4 3 GO:0042102 positive regulation of T cell proliferation 6/852 101/18722 0.311714059742562 0.569377505886039 IGF2/EBI3/IL6ST/CD276/EFNB1/SLC7A1 6 GO:0051963 regulation of synapse assembly 6/852 101/18722 0.311714059742562 0.569377505886039 IL1RAP/PDLIM5/PTPRS/GPC4/EPHB2/TPBG 6 GO:0045576 mast cell activation 4/852 62/18722 0.311783112700561 0.569377505886039 GATA2/SNAP23/NDRG1/S100A13 4 GO:0046148 pigment biosynthetic process 4/852 62/18722 0.311783112700561 0.569377505886039 TSPO/PGRMC1/OPN3/MFSD12 4 GO:0046173 polyol biosynthetic process 4/852 62/18722 0.311783112700561 0.569377505886039 PTK2B/IPMK/GBA/IMPA2 4 GO:0034341 response to interferon-gamma 8/852 141/18722 0.312713320415242 0.570479037466453 FLNB/IFNGR2/SEC61A1/DAPK1/JAK1/BST2/TP53/MYO1C 8 GO:0048284 organelle fusion 8/852 141/18722 0.312713320415242 0.570479037466453 VAT1/RAB8B/SNAP23/CAV2/USO1/ARL8B/SEC22B/YIPF5 8 GO:0042752 regulation of circadian rhythm 7/852 121/18722 0.312839686748939 0.570479037466453 OPN3/PPP1CB/MAGED1/KLF10/TP53/DDB1/GNAQ 7 GO:0048706 embryonic skeletal system development 7/852 121/18722 0.312839686748939 0.570479037466453 NOG/SMAD3/MMP14/GRHL2/CTNNB1/MYCN/RDH10 7 GO:0019722 calcium-mediated signaling 11/852 202/18722 0.314184889739937 0.570881145807422 POMC/PTK2B/CCR1/EDNRB/FHL2/RCAN1/ACKR2/PPP3CA/P2RX4/CAMTA1/NFAT5 11 GO:0009615 response to virus 19/852 367/18722 0.314194540419944 0.570881145807422 HTRA1/GATA3/IFI27/SMAD3/VWCE/HSPB1/ISG15/TNFAIP3/IFNGR2/NPC2/STAT2/BST2/SERINC3/IFNAR1/SEC14L1/FMR1/PCBP2/DDX17/DNAJC3 19 GO:0002696 positive regulation of leukocyte activation 21/852 409/18722 0.315541454632747 0.570881145807422 IGF2/EBI3/IL6ST/HLA-G/GATA3/CD276/GATA2/TGFB1/EFNB1/SLC7A1/EPHB2/SOX4/XBP1/MMP14/CD320/LAMP1/MIF/AP1G1/MDK/HSPH1/DPP4 21 GO:0003094 glomerular filtration 2/852 25/18722 0.315895885371283 0.570881145807422 MCAM/GJA5 2 GO:0015874 norepinephrine transport 2/852 25/18722 0.315895885371283 0.570881145807422 SLC6A2/ACTB 2 GO:0016540 protein autoprocessing 2/852 25/18722 0.315895885371283 0.570881145807422 CTSL/CAPN2 2 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 2/852 25/18722 0.315895885371283 0.570881145807422 TNFAIP3/SASH1 2 GO:0032331 negative regulation of chondrocyte differentiation 2/852 25/18722 0.315895885371283 0.570881145807422 LTBP3/CTNNB1 2 GO:0032753 positive regulation of interleukin-4 production 2/852 25/18722 0.315895885371283 0.570881145807422 IL1RAP/GATA3 2 GO:0033233 regulation of protein sumoylation 2/852 25/18722 0.315895885371283 0.570881145807422 CTNNB1/EGR1 2 GO:0033622 integrin activation 2/852 25/18722 0.315895885371283 0.570881145807422 FN1/FBLIM1 2 GO:0042730 fibrinolysis 2/852 25/18722 0.315895885371283 0.570881145807422 SERPINE1/SERPING1 2 GO:0044550 secondary metabolite biosynthetic process 2/852 25/18722 0.315895885371283 0.570881145807422 OPN3/MFSD12 2 GO:0050927 positive regulation of positive chemotaxis 2/852 25/18722 0.315895885371283 0.570881145807422 SMAD3/PGF 2 GO:0050995 negative regulation of lipid catabolic process 2/852 25/18722 0.315895885371283 0.570881145807422 APOC1/MFSD2A 2 GO:0060740 prostate gland epithelium morphogenesis 2/852 25/18722 0.315895885371283 0.570881145807422 NOG/SFRP1 2 GO:0062009 secondary palate development 2/852 25/18722 0.315895885371283 0.570881145807422 TGFB2/TGFBR3 2 GO:0072012 glomerulus vasculature development 2/852 25/18722 0.315895885371283 0.570881145807422 NOTCH2/EGR1 2 GO:0072207 metanephric epithelium development 2/852 25/18722 0.315895885371283 0.570881145807422 WWTR1/LAMB2 2 GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/852 25/18722 0.315895885371283 0.570881145807422 KCNJ2/FLNA 2 GO:0090312 positive regulation of protein deacetylation 2/852 25/18722 0.315895885371283 0.570881145807422 PINK1/TP53 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/852 25/18722 0.315895885371283 0.570881145807422 IGF2/MYO1C 2 GO:1902993 positive regulation of amyloid precursor protein catabolic process 2/852 25/18722 0.315895885371283 0.570881145807422 EFNA1/PICALM 2 GO:1903901 negative regulation of viral life cycle 2/852 25/18722 0.315895885371283 0.570881145807422 BST2/GSN 2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 2/852 25/18722 0.315895885371283 0.570881145807422 MDK/NFAT5 2 GO:0002274 myeloid leukocyte activation 12/852 223/18722 0.31723654876792 0.573098187347072 DNASE1L3/GATA2/GRN/NOTCH2/IFNGR2/ADAM10/ADAM9/SNAP23/LDLR/NDRG1/MIF/S100A13 12 GO:0001910 regulation of leukocyte mediated cytotoxicity 5/852 82/18722 0.317501361454352 0.573261820858457 HLA-G/DNASE1L3/PVR/LAMP1/AP1G1 5 GO:0006936 muscle contraction 18/852 347/18722 0.317554928780723 0.573261820858457 TPM1/DOCK5/TPM2/KCNJ2/FLNA/EDNRB/GAA/PKP2/CALD1/DSG2/GJA5/C12orf57/CTTN/SLC6A8/P2RX4/JUP/GSN/SRI 18 GO:0034308 primary alcohol metabolic process 6/852 102/18722 0.319776404686714 0.576858295623022 TTR/GDPD3/CYP11A1/DHRS3/H6PD/RDH10 6 GO:0062014 negative regulation of small molecule metabolic process 6/852 102/18722 0.319776404686714 0.576858295623022 APOC1/APOE/MFSD2A/FAM3C/INSIG1/TP53 6 GO:0050868 negative regulation of T cell activation 7/852 122/18722 0.32019064183809 0.577191798127187 HLA-G/SDC4/ERBB2/CBLB/LGALS3/NDFIP1/MDK 7 GO:0051208 sequestering of calcium ion 7/852 122/18722 0.32019064183809 0.577191798127187 PTK2B/CALR/HSP90B1/UBASH3B/ITPR2/ERO1A/SRI 7 GO:0001756 somitogenesis 4/852 63/18722 0.322189526940334 0.57993750707324 SFRP1/SMAD3/TMED2/TP53 4 GO:0016239 positive regulation of macroautophagy 4/852 63/18722 0.322189526940334 0.57993750707324 PINK1/PAFAH1B2/MAPK3/SH3GLB1 4 GO:0031343 positive regulation of cell killing 4/852 63/18722 0.322189526940334 0.57993750707324 HLA-G/PVR/LAMP1/AP1G1 4 GO:2000756 regulation of peptidyl-lysine acetylation 4/852 63/18722 0.322189526940334 0.57993750707324 GATA3/GATA2/SOX4/MAPK3 4 GO:0002819 regulation of adaptive immune response 10/852 183/18722 0.322289927932416 0.57993750707324 IL6ST/HLA-G/IL1R1/GATA3/TGFB1/PVR/TNFAIP3/PKN1/ADCY7/NDFIP1 10 GO:0032984 protein-containing complex disassembly 12/852 224/18722 0.322635586520136 0.580352003915599 SEMA5A/CAPG/LIMA1/INSR/ARHGEF2/GBA/SH3GL1/DSTN/CCSAP/MICAL3/GSN/LAMP2 12 GO:0008542 visual learning 3/852 44/18722 0.323911632798056 0.58181557739922 ITGB1/ABCA7/NPTN 3 GO:0042554 superoxide anion generation 3/852 44/18722 0.323911632798056 0.58181557739922 SH3PXD2A/SH3PXD2B/TGFB1 3 GO:0048066 developmental pigmentation 3/852 44/18722 0.323911632798056 0.58181557739922 CD63/EDNRB/AP1G1 3 GO:0150076 neuroinflammatory response 3/852 44/18722 0.323911632798056 0.58181557739922 ITGB1/GRN/LDLR 3 GO:0061025 membrane fusion 9/852 163/18722 0.324493959290117 0.582445826357761 CD9/CTSL/RAB8B/SNAP23/CAV2/USO1/ARL8B/SEC22B/YIPF5 9 GO:0072331 signal transduction by p53 class mediator 9/852 163/18722 0.324493959290117 0.582445826357761 NUAK1/SOX4/RPS27L/PLK2/NDRG1/MIF/MYO6/TP53/SHISA5 9 GO:0050886 endocrine process 5/852 83/18722 0.326545005345545 0.585500894871439 GATA3/POMC/INHA/RAB8B/CTSZ 5 GO:0051899 membrane depolarization 5/852 83/18722 0.326545005345545 0.585500894871439 TSPO/KCNJ2/GJA5/P2RX4/PTPN3 5 GO:0061053 somite development 5/852 83/18722 0.326545005345545 0.585500894871439 NOG/SFRP1/SMAD3/TMED2/TP53 5 GO:0019233 sensory perception of pain 6/852 103/18722 0.327869139547693 0.587456525220198 PTGES/EDNRB/MGLL/FABP5/MAPK3/P2RX4 6 GO:0032760 positive regulation of tumor necrosis factor production 6/852 103/18722 0.327869139547693 0.587456525220198 LPL/EPHB2/HSPB1/ARHGEF2/MIF/PIK3R1 6 GO:0007051 spindle organization 10/852 184/18722 0.328296029948256 0.588012070722268 MAPRE2/FLNA/PLK2/CCDC69/MYH9/SUN2/CCSAP/EZR/TACC1/MAP4 10 GO:0017156 calcium-ion regulated exocytosis 4/852 64/18722 0.332619671976286 0.590890484615254 SYT8/MYH9/SDF4/ARL8B 4 GO:0030888 regulation of B cell proliferation 4/852 64/18722 0.332619671976286 0.590890484615254 EPHB2/PKN1/CD320/MIF 4 GO:0046530 photoreceptor cell differentiation 4/852 64/18722 0.332619671976286 0.590890484615254 PTN/MFSD2A/NAGLU/TUG1 4 GO:0046579 positive regulation of Ras protein signal transduction 4/852 64/18722 0.332619671976286 0.590890484615254 F11R/MAPRE2/NOTCH2/PIK3CB 4 GO:0046854 phosphatidylinositol phosphate biosynthetic process 4/852 64/18722 0.332619671976286 0.590890484615254 IPMK/PIK3CB/PIK3R1/IMPA2 4 GO:1900076 regulation of cellular response to insulin stimulus 4/852 64/18722 0.332619671976286 0.590890484615254 IGF2/LPL/USO1/MYO1C 4 GO:0001963 synaptic transmission, dopaminergic 2/852 26/18722 0.33283817283613 0.590890484615254 SLC6A2/PINK1 2 GO:0002026 regulation of the force of heart contraction 2/852 26/18722 0.33283817283613 0.590890484615254 ADM/GAA 2 GO:0002407 dendritic cell chemotaxis 2/852 26/18722 0.33283817283613 0.590890484615254 CCR1/CALR 2 GO:0002418 immune response to tumor cell 2/852 26/18722 0.33283817283613 0.590890484615254 ADAM15/PVR 2 GO:0006706 steroid catabolic process 2/852 26/18722 0.33283817283613 0.590890484615254 APOE/SCARB1 2 GO:0014829 vascular associated smooth muscle contraction 2/852 26/18722 0.33283817283613 0.590890484615254 DOCK5/EDNRB 2 GO:0021952 central nervous system projection neuron axonogenesis 2/852 26/18722 0.33283817283613 0.590890484615254 EPHB2/C12orf57 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/852 26/18722 0.33283817283613 0.590890484615254 MGAT5/LGALS3 2 GO:0033522 histone H2A ubiquitination 2/852 26/18722 0.33283817283613 0.590890484615254 DDB1/UBE2A 2 GO:0048499 synaptic vesicle membrane organization 2/852 26/18722 0.33283817283613 0.590890484615254 SNAP23/SYNGR2 2 GO:0050926 regulation of positive chemotaxis 2/852 26/18722 0.33283817283613 0.590890484615254 SMAD3/PGF 2 GO:0051016 barbed-end actin filament capping 2/852 26/18722 0.33283817283613 0.590890484615254 CAPG/GSN 2 GO:0060219 camera-type eye photoreceptor cell differentiation 2/852 26/18722 0.33283817283613 0.590890484615254 PTN/NAGLU 2 GO:0070102 interleukin-6-mediated signaling pathway 2/852 26/18722 0.33283817283613 0.590890484615254 IL6ST/JAK1 2 GO:0097205 renal filtration 2/852 26/18722 0.33283817283613 0.590890484615254 MCAM/GJA5 2 GO:1902186 regulation of viral release from host cell 2/852 26/18722 0.33283817283613 0.590890484615254 CAV2/DDB1 2 GO:1904353 regulation of telomere capping 2/852 26/18722 0.33283817283613 0.590890484615254 TNKS2/MAPK3 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/852 26/18722 0.33283817283613 0.590890484615254 SFRP1/TIAM1 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/852 26/18722 0.33283817283613 0.590890484615254 PIK3CB/TP53 2 GO:0007612 learning 8/852 144/18722 0.333169291088843 0.591061347215421 ITGB1/PTN/ABCA7/EPHB2/INSR/TPBG/ARF4/NPTN 8 GO:0033135 regulation of peptidyl-serine phosphorylation 8/852 144/18722 0.333169291088843 0.591061347215421 PLCL2/TGFB1/SMYD3/PINK1/TXN/MIF/BCAR3/SH2D3A 8 GO:0043433 negative regulation of DNA-binding transcription factor activity 10/852 185/18722 0.334324189112938 0.592901213462093 TCF7L2/ID3/FLNA/TNFAIP3/WFS1/ANXA4/DAP/NLRP2/ID1/SRI 10 GO:0001909 leukocyte mediated cytotoxicity 7/852 124/18722 0.334976513915271 0.593848818082269 HLA-G/DNASE1L3/PVR/LAMP1/ARL8B/AP1G1/CTSH 7 GO:0042310 vasoconstriction 5/852 84/18722 0.335614782480398 0.593888467099761 ADM/DOCK5/EDNRB/BMPR2/GJA5 5 GO:0045621 positive regulation of lymphocyte differentiation 6/852 104/18722 0.335988294875348 0.593888467099761 HLA-G/GATA3/SOX4/XBP1/MMP14/MDK 6 GO:0003009 skeletal muscle contraction 3/852 45/18722 0.336532864726509 0.593888467099761 KCNJ2/GAA/C12orf57 3 GO:0003254 regulation of membrane depolarization 3/852 45/18722 0.336532864726509 0.593888467099761 TSPO/GJA5/PTPN3 3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 3/852 45/18722 0.336532864726509 0.593888467099761 P4HB/HSPB1/PINK1 3 GO:0030835 negative regulation of actin filament depolymerization 3/852 45/18722 0.336532864726509 0.593888467099761 CAPG/LIMA1/GSN 3 GO:0035305 negative regulation of dephosphorylation 3/852 45/18722 0.336532864726509 0.593888467099761 MGAT5/TGFB2/LGALS3 3 GO:0035384 thioester biosynthetic process 3/852 45/18722 0.336532864726509 0.593888467099761 TECR/ACSL4/ACSL3 3 GO:0048546 digestive tract morphogenesis 3/852 45/18722 0.336532864726509 0.593888467099761 SFRP1/SMAD3/CTNNB1 3 GO:0060119 inner ear receptor cell development 3/852 45/18722 0.336532864726509 0.593888467099761 SLC4A7/SDC4/NAGLU 3 GO:0071354 cellular response to interleukin-6 3/852 45/18722 0.336532864726509 0.593888467099761 IL6ST/JAK1/ST3GAL6 3 GO:0071616 acyl-CoA biosynthetic process 3/852 45/18722 0.336532864726509 0.593888467099761 TECR/ACSL4/ACSL3 3 GO:1901985 positive regulation of protein acetylation 3/852 45/18722 0.336532864726509 0.593888467099761 GATA3/SOX4/MAPK3 3 GO:0098657 import into cell 12/852 227/18722 0.338953914207978 0.597951296953647 ITGB1/SLC6A2/SLC39A6/SLC12A8/SLC39A8/SLC7A1/KCNJ2/ACTB/SLC1A5/SLC15A3/SLC1A3/ACSL3 12 GO:0007346 regulation of mitotic cell cycle 23/852 457/18722 0.33920377458002 0.598182409762173 IGF2/TIMP2/ADAMTS1/SMAD3/TGFB1/SOX4/CDKN1C/RPS27L/EIF4EBP1/INSR/PLK2/CTNNB1/CAV2/ZFP36L1/JADE1/IQGAP1/CTDSP1/TP53/DDB1/PTPN3/WEE1/ADAM17/OBSL1 23 GO:0071706 tumor necrosis factor superfamily cytokine production 10/852 186/18722 0.340372789436102 0.599823616677836 TSPO/POMC/LPL/EPHB2/HSPB1/TNFAIP3/ARHGEF2/MIF/PIK3R1/ERRFI1 10 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 10/852 186/18722 0.340372789436102 0.599823616677836 TSPO/POMC/LPL/EPHB2/HSPB1/TNFAIP3/ARHGEF2/MIF/PIK3R1/ERRFI1 10 GO:0002720 positive regulation of cytokine production involved in immune response 4/852 65/18722 0.343065414511708 0.603723157775324 HLA-G/IL1R1/GATA3/SEMA7A 4 GO:0015909 long-chain fatty acid transport 4/852 65/18722 0.343065414511708 0.603723157775324 APOE/MFSD2A/FABP5/ACSL3 4 GO:0035418 protein localization to synapse 4/852 65/18722 0.343065414511708 0.603723157775324 GPC4/HSPB1/ADAM10/DAG1 4 GO:1902475 L-alpha-amino acid transmembrane transport 4/852 65/18722 0.343065414511708 0.603723157775324 ITGB1/SLC7A1/SLC1A5/SLC1A3 4 GO:0040029 regulation of gene expression, epigenetic 6/852 105/18722 0.344129941962962 0.605173304646956 IGF2/HDAC5/XIST/MBD2/TFAP2C/MBD3 6 GO:0062207 regulation of pattern recognition receptor signaling pathway 6/852 105/18722 0.344129941962962 0.605173304646956 PTPRS/TNFAIP3/RTN4/SLC15A3/XIAP/SEC14L1 6 GO:0010828 positive regulation of glucose transmembrane transport 3/852 46/18722 0.349140722826972 0.60999100344579 INSR/OPN3/PIK3R1 3 GO:0031294 lymphocyte costimulation 3/852 46/18722 0.349140722826972 0.60999100344579 EFNB1/CD320/DPP4 3 GO:0043300 regulation of leukocyte degranulation 3/852 46/18722 0.349140722826972 0.60999100344579 GATA2/LAMP1/AP1G1 3 GO:0046839 phospholipid dephosphorylation 3/852 46/18722 0.349140722826972 0.60999100344579 PLPP3/SGPP1/INPPL1 3 GO:0000737 DNA catabolic process, endonucleolytic 2/852 27/18722 0.349657072310968 0.60999100344579 DNASE1L3/ENDOG 2 GO:0001958 endochondral ossification 2/852 27/18722 0.349657072310968 0.60999100344579 MMP14/INPPL1 2 GO:0003401 axis elongation 2/852 27/18722 0.349657072310968 0.60999100344579 SFRP1/RDH10 2 GO:0006783 heme biosynthetic process 2/852 27/18722 0.349657072310968 0.60999100344579 TSPO/PGRMC1 2 GO:0010586 miRNA metabolic process 2/852 27/18722 0.349657072310968 0.60999100344579 DDX17/KCNQ1OT1 2 GO:0010894 negative regulation of steroid biosynthetic process 2/852 27/18722 0.349657072310968 0.60999100344579 APOE/INSIG1 2 GO:0015813 L-glutamate transmembrane transport 2/852 27/18722 0.349657072310968 0.60999100344579 ITGB1/SLC1A3 2 GO:0018195 peptidyl-arginine modification 2/852 27/18722 0.349657072310968 0.60999100344579 KRTCAP2/CARM1 2 GO:0018904 ether metabolic process 2/852 27/18722 0.349657072310968 0.60999100344579 PLA2G7/TXN 2 GO:0032967 positive regulation of collagen biosynthetic process 2/852 27/18722 0.349657072310968 0.60999100344579 ENG/TGFB1 2 GO:0033688 regulation of osteoblast proliferation 2/852 27/18722 0.349657072310968 0.60999100344579 SFRP1/SMAD3 2 GO:0034698 response to gonadotropin 2/852 27/18722 0.349657072310968 0.60999100344579 PAPPA/TGFBR3 2 GO:0035235 ionotropic glutamate receptor signaling pathway 2/852 27/18722 0.349657072310968 0.60999100344579 PTK2B/TIAM1 2 GO:0036075 replacement ossification 2/852 27/18722 0.349657072310968 0.60999100344579 MMP14/INPPL1 2 GO:0042402 cellular biogenic amine catabolic process 2/852 27/18722 0.349657072310968 0.60999100344579 MAOA/SAT1 2 GO:0060512 prostate gland morphogenesis 2/852 27/18722 0.349657072310968 0.60999100344579 NOG/SFRP1 2 GO:0061437 renal system vasculature development 2/852 27/18722 0.349657072310968 0.60999100344579 NOTCH2/EGR1 2 GO:0061440 kidney vasculature development 2/852 27/18722 0.349657072310968 0.60999100344579 NOTCH2/EGR1 2 GO:1902914 regulation of protein polyubiquitination 2/852 27/18722 0.349657072310968 0.60999100344579 SASH1/XIAP 2 GO:0019229 regulation of vasoconstriction 4/852 66/18722 0.3535188418968 0.616514321298196 ADM/DOCK5/BMPR2/GJA5 4 GO:0022406 membrane docking 5/852 86/18722 0.353811122455106 0.616810314969363 RAB8B/CTBP2/CAV2/USO1/EZR 5 GO:1902806 regulation of cell cycle G1/S phase transition 9/852 168/18722 0.356638941533974 0.621524858982164 ADAMTS1/SOX4/RPS27L/PLK2/JADE1/CTDSP1/TP53/WEE1/ADAM17 9 GO:0009410 response to xenobiotic stimulus 23/852 462/18722 0.358578280406589 0.62188422699089 TIMP2/ENG/SFRP1/PTN/GATA3/SLC6A2/TSPO/PAM/LPL/TGFB2/PTK2B/PGF/ABCA1/CALR/RPN2/NCOA1/FOSB/VKORC1/MYO6/BCAR3/SLC1A3/MDK/ADAM17 23 GO:0050867 positive regulation of cell activation 21/852 420/18722 0.359881877043537 0.62188422699089 IGF2/EBI3/IL6ST/HLA-G/GATA3/CD276/GATA2/TGFB1/EFNB1/SLC7A1/EPHB2/SOX4/XBP1/MMP14/CD320/LAMP1/MIF/AP1G1/MDK/HSPH1/DPP4 21 GO:0051341 regulation of oxidoreductase activity 6/852 107/18722 0.360465225920597 0.62188422699089 PTK2B/APOE/SCARB1/HM13/PIK3CB/RFK 6 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 6/852 107/18722 0.360465225920597 0.62188422699089 LPL/EPHB2/HSPB1/ARHGEF2/MIF/PIK3R1 6 GO:1903900 regulation of viral life cycle 8/852 148/18722 0.360753397841585 0.62188422699089 P4HB/ISG15/PABPC1/BST2/CAV2/DDB1/GSN/FMR1 8 GO:0001754 eye photoreceptor cell differentiation 3/852 47/18722 0.361722467473017 0.62188422699089 PTN/NAGLU/TUG1 3 GO:0001774 microglial cell activation 3/852 47/18722 0.361722467473017 0.62188422699089 GRN/IFNGR2/LDLR 3 GO:0006998 nuclear envelope organization 3/852 47/18722 0.361722467473017 0.62188422699089 SUN2/REEP3/CTDNEP1 3 GO:0010799 regulation of peptidyl-threonine phosphorylation 3/852 47/18722 0.361722467473017 0.62188422699089 PRKAG2/TGFB1/UBE2K 3 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 3/852 47/18722 0.361722467473017 0.62188422699089 TNFAIP3/UBE2K/ADAM17 3 GO:0048512 circadian behavior 3/852 47/18722 0.361722467473017 0.62188422699089 NAGLU/EGR1/TP53 3 GO:1900744 regulation of p38MAPK cascade 3/852 47/18722 0.361722467473017 0.62188422699089 SASH1/EZR/EMC10 3 GO:0016101 diterpenoid metabolic process 5/852 87/18722 0.362927121034781 0.62188422699089 TTR/CRABP2/DHRS3/LRP1/RDH10 5 GO:1903578 regulation of ATP metabolic process 5/852 87/18722 0.362927121034781 0.62188422699089 TSPO/PRKAG2/INSR/PINK1/TP53 5 GO:0018394 peptidyl-lysine acetylation 9/852 169/18722 0.363120107039282 0.62188422699089 GATA3/GATA2/SOX4/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 9 GO:0006879 cellular iron ion homeostasis 4/852 67/18722 0.363972269281892 0.62188422699089 SLC39A8/NDFIP1/SRI/ATP6AP1 4 GO:0000423 mitophagy 2/852 28/18722 0.366328741104495 0.62188422699089 PINK1/TP53 2 GO:0001945 lymph vessel development 2/852 28/18722 0.366328741104495 0.62188422699089 ACVRL1/BMPR2 2 GO:0003156 regulation of animal organ formation 2/852 28/18722 0.366328741104495 0.62188422699089 CITED2/CTNNB1 2 GO:0010460 positive regulation of heart rate 2/852 28/18722 0.366328741104495 0.62188422699089 TPM1/ADM 2 GO:0010714 positive regulation of collagen metabolic process 2/852 28/18722 0.366328741104495 0.62188422699089 ENG/TGFB1 2 GO:0010818 T cell chemotaxis 2/852 28/18722 0.366328741104495 0.62188422699089 ADAM10/ADAM17 2 GO:0010884 positive regulation of lipid storage 2/852 28/18722 0.366328741104495 0.62188422699089 LPL/SCARB1 2 GO:0015740 C4-dicarboxylate transport 2/852 28/18722 0.366328741104495 0.62188422699089 SLC1A5/SLC1A3 2 GO:0030262 apoptotic nuclear changes 2/852 28/18722 0.366328741104495 0.62188422699089 DNASE1L3/ENDOG 2 GO:0032958 inositol phosphate biosynthetic process 2/852 28/18722 0.366328741104495 0.62188422699089 PTK2B/IPMK 2 GO:0045589 regulation of regulatory T cell differentiation 2/852 28/18722 0.366328741104495 0.62188422699089 HLA-G/MDK 2 GO:0071280 cellular response to copper ion 2/852 28/18722 0.366328741104495 0.62188422699089 AOC1/MT1X 2 GO:0080111 DNA demethylation 2/852 28/18722 0.366328741104495 0.62188422699089 GATA3/TET3 2 GO:0086011 membrane repolarization during action potential 2/852 28/18722 0.366328741104495 0.62188422699089 KCNJ2/FLNA 2 GO:0090344 negative regulation of cell aging 2/852 28/18722 0.366328741104495 0.62188422699089 PLK2/MIF 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/852 28/18722 0.366328741104495 0.62188422699089 FLNA/GJA5 2 GO:1902624 positive regulation of neutrophil migration 2/852 28/18722 0.366328741104495 0.62188422699089 IL1R1/MDK 2 GO:1903649 regulation of cytoplasmic transport 2/852 28/18722 0.366328741104495 0.62188422699089 MAPK3/EZR 2 GO:1903671 negative regulation of sprouting angiogenesis 2/852 28/18722 0.366328741104495 0.62188422699089 PIK3CB/EPN2 2 GO:1903672 positive regulation of sprouting angiogenesis 2/852 28/18722 0.366328741104495 0.62188422699089 ITGA5/JAK1 2 GO:0018209 peptidyl-serine modification 17/852 338/18722 0.370881576379319 0.62188422699089 BGN/PLCL2/GALNT3/TGFB1/GALNT2/SMYD3/PKN1/PLK2/PINK1/TXN/MIF/MAPK3/BCAR3/CSNK1A1/HIPK3/GALNT1/SH2D3A 17 GO:0030258 lipid modification 11/852 212/18722 0.371629779004737 0.62188422699089 PRKAG2/APOC1/PLA2G7/APOE/MFSD2A/PLPP3/SGPP1/GBA/ACOX1/DGKZ/INPPL1 11 GO:0001553 luteinization 1/852 10/18722 0.372413880419341 0.62188422699089 PLEKHA1 1 GO:0001915 negative regulation of T cell mediated cytotoxicity 1/852 10/18722 0.372413880419341 0.62188422699089 HLA-G 1 GO:0002002 regulation of angiotensin levels in blood 1/852 10/18722 0.372413880419341 0.62188422699089 CTSZ 1 GO:0002003 angiotensin maturation 1/852 10/18722 0.372413880419341 0.62188422699089 CTSZ 1 GO:0002084 protein depalmitoylation 1/852 10/18722 0.372413880419341 0.62188422699089 LYPLA1 1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1/852 10/18722 0.372413880419341 0.62188422699089 LGALS3 1 GO:0002524 hypersensitivity 1/852 10/18722 0.372413880419341 0.62188422699089 GATA3 1 GO:0002765 immune response-inhibiting signal transduction 1/852 10/18722 0.372413880419341 0.62188422699089 HLA-G 1 GO:0003056 regulation of vascular associated smooth muscle contraction 1/852 10/18722 0.372413880419341 0.62188422699089 DOCK5 1 GO:0006171 cAMP biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 ADCY7 1 GO:0006222 UMP biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 CMPK1 1 GO:0006560 proline metabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 PYCR1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 CMPK1 1 GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 CMPK1 1 GO:0010968 regulation of microtubule nucleation 1/852 10/18722 0.372413880419341 0.62188422699089 ARHGEF7 1 GO:0014041 regulation of neuron maturation 1/852 10/18722 0.372413880419341 0.62188422699089 EDNRB 1 GO:0016081 synaptic vesicle docking 1/852 10/18722 0.372413880419341 0.62188422699089 CTBP2 1 GO:0019614 catechol-containing compound catabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 MAOA 1 GO:0030214 hyaluronan catabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 TGFB1 1 GO:0030953 astral microtubule organization 1/852 10/18722 0.372413880419341 0.62188422699089 EZR 1 GO:0031284 positive regulation of guanylate cyclase activity 1/852 10/18722 0.372413880419341 0.62188422699089 GUCA2A 1 GO:0031642 negative regulation of myelination 1/852 10/18722 0.372413880419341 0.62188422699089 JAM2 1 GO:0031915 positive regulation of synaptic plasticity 1/852 10/18722 0.372413880419341 0.62188422699089 EPHB2 1 GO:0031943 regulation of glucocorticoid metabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 H6PD 1 GO:0032525 somite rostral/caudal axis specification 1/852 10/18722 0.372413880419341 0.62188422699089 TMED2 1 GO:0033080 immature T cell proliferation in thymus 1/852 10/18722 0.372413880419341 0.62188422699089 ERBB2 1 GO:0034651 cortisol biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 H6PD 1 GO:0035768 endothelial cell chemotaxis to fibroblast growth factor 1/852 10/18722 0.372413880419341 0.62188422699089 FGFR1 1 GO:0035871 protein K11-linked deubiquitination 1/852 10/18722 0.372413880419341 0.62188422699089 TNFAIP3 1 GO:0038007 netrin-activated signaling pathway 1/852 10/18722 0.372413880419341 0.62188422699089 PTK2 1 GO:0042045 epithelial fluid transport 1/852 10/18722 0.372413880419341 0.62188422699089 EDNRB 1 GO:0042424 catecholamine catabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 MAOA 1 GO:0042711 maternal behavior 1/852 10/18722 0.372413880419341 0.62188422699089 MBD2 1 GO:0043084 penile erection 1/852 10/18722 0.372413880419341 0.62188422699089 EDNRB 1 GO:0044351 macropinocytosis 1/852 10/18722 0.372413880419341 0.62188422699089 DNM2 1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence 1/852 10/18722 0.372413880419341 0.62188422699089 EMC10 1 GO:0045348 positive regulation of MHC class II biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 XBP1 1 GO:0045843 negative regulation of striated muscle tissue development 1/852 10/18722 0.372413880419341 0.62188422699089 TGFB1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/852 10/18722 0.372413880419341 0.62188422699089 TP53 1 GO:0048251 elastic fiber assembly 1/852 10/18722 0.372413880419341 0.62188422699089 LTBP3 1 GO:0048262 determination of dorsal/ventral asymmetry 1/852 10/18722 0.372413880419341 0.62188422699089 CTNNB1 1 GO:0048340 paraxial mesoderm morphogenesis 1/852 10/18722 0.372413880419341 0.62188422699089 SMAD3 1 GO:0048671 negative regulation of collateral sprouting 1/852 10/18722 0.372413880419341 0.62188422699089 PTPRS 1 GO:0048703 embryonic viscerocranium morphogenesis 1/852 10/18722 0.372413880419341 0.62188422699089 RDH10 1 GO:0048755 branching morphogenesis of a nerve 1/852 10/18722 0.372413880419341 0.62188422699089 RTN4 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/852 10/18722 0.372413880419341 0.62188422699089 CMTM3 1 GO:0051660 establishment of centrosome localization 1/852 10/18722 0.372413880419341 0.62188422699089 EZR 1 GO:0051918 negative regulation of fibrinolysis 1/852 10/18722 0.372413880419341 0.62188422699089 SERPINE1 1 GO:0051974 negative regulation of telomerase activity 1/852 10/18722 0.372413880419341 0.62188422699089 TP53 1 GO:0060513 prostatic bud formation 1/852 10/18722 0.372413880419341 0.62188422699089 NOG 1 GO:0060525 prostate glandular acinus development 1/852 10/18722 0.372413880419341 0.62188422699089 SFRP1 1 GO:0060736 prostate gland growth 1/852 10/18722 0.372413880419341 0.62188422699089 PSAP 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/852 10/18722 0.372413880419341 0.62188422699089 CTNNB1 1 GO:0061085 regulation of histone H3-K27 methylation 1/852 10/18722 0.372413880419341 0.62188422699089 GATA3 1 GO:0071421 manganese ion transmembrane transport 1/852 10/18722 0.372413880419341 0.62188422699089 SLC39A8 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/852 10/18722 0.372413880419341 0.62188422699089 EGR1 1 GO:0072178 nephric duct morphogenesis 1/852 10/18722 0.372413880419341 0.62188422699089 GATA3 1 GO:0072203 cell proliferation involved in metanephros development 1/852 10/18722 0.372413880419341 0.62188422699089 EGR1 1 GO:0090179 planar cell polarity pathway involved in neural tube closure 1/852 10/18722 0.372413880419341 0.62188422699089 SFRP1 1 GO:0090209 negative regulation of triglyceride metabolic process 1/852 10/18722 0.372413880419341 0.62188422699089 APOE 1 GO:0090527 actin filament reorganization 1/852 10/18722 0.372413880419341 0.62188422699089 GSN 1 GO:0090647 modulation of age-related behavioral decline 1/852 10/18722 0.372413880419341 0.62188422699089 PICALM 1 GO:0097278 complement-dependent cytotoxicity 1/852 10/18722 0.372413880419341 0.62188422699089 CD59 1 GO:0098885 modification of postsynaptic actin cytoskeleton 1/852 10/18722 0.372413880419341 0.62188422699089 TIAM1 1 GO:0098903 regulation of membrane repolarization during action potential 1/852 10/18722 0.372413880419341 0.62188422699089 FLNA 1 GO:1901524 regulation of mitophagy 1/852 10/18722 0.372413880419341 0.62188422699089 TP53 1 GO:1901725 regulation of histone deacetylase activity 1/852 10/18722 0.372413880419341 0.62188422699089 PINK1 1 GO:1902023 L-arginine transport 1/852 10/18722 0.372413880419341 0.62188422699089 SLC7A1 1 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/852 10/18722 0.372413880419341 0.62188422699089 SERINC3 1 GO:1902513 regulation of organelle transport along microtubule 1/852 10/18722 0.372413880419341 0.62188422699089 LAMP1 1 GO:1902645 tertiary alcohol biosynthetic process 1/852 10/18722 0.372413880419341 0.62188422699089 H6PD 1 GO:1902946 protein localization to early endosome 1/852 10/18722 0.372413880419341 0.62188422699089 EZR 1 GO:1903826 arginine transmembrane transport 1/852 10/18722 0.372413880419341 0.62188422699089 SLC7A1 1 GO:1905383 protein localization to presynapse 1/852 10/18722 0.372413880419341 0.62188422699089 HSPB1 1 GO:1905651 regulation of artery morphogenesis 1/852 10/18722 0.372413880419341 0.62188422699089 MDK 1 GO:1905809 negative regulation of synapse organization 1/852 10/18722 0.372413880419341 0.62188422699089 PTN 1 GO:1905941 positive regulation of gonad development 1/852 10/18722 0.372413880419341 0.62188422699089 CITED2 1 GO:1990253 cellular response to leucine starvation 1/852 10/18722 0.372413880419341 0.62188422699089 GCN1 1 GO:1990535 neuron projection maintenance 1/852 10/18722 0.372413880419341 0.62188422699089 INSR 1 GO:2000018 regulation of male gonad development 1/852 10/18722 0.372413880419341 0.62188422699089 CITED2 1 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 1/852 10/18722 0.372413880419341 0.62188422699089 TXN 1 GO:2000425 regulation of apoptotic cell clearance 1/852 10/18722 0.372413880419341 0.62188422699089 ABCA7 1 GO:2000434 regulation of protein neddylation 1/852 10/18722 0.372413880419341 0.62188422699089 EPAS1 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/852 10/18722 0.372413880419341 0.62188422699089 CALR 1 GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 1/852 10/18722 0.372413880419341 0.62188422699089 FGFR1 1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 1/852 10/18722 0.372413880419341 0.62188422699089 NCKAP1 1 GO:2000849 regulation of glucocorticoid secretion 1/852 10/18722 0.372413880419341 0.62188422699089 POMC 1 GO:2001223 negative regulation of neuron migration 1/852 10/18722 0.372413880419341 0.62188422699089 SRGAP2 1 GO:0035036 sperm-egg recognition 3/852 48/18722 0.374265989665894 0.623576118654372 CD9/B4GALT1/LY6K 3 GO:0043303 mast cell degranulation 3/852 48/18722 0.374265989665894 0.623576118654372 GATA2/SNAP23/S100A13 3 GO:0045912 negative regulation of carbohydrate metabolic process 3/852 48/18722 0.374265989665894 0.623576118654372 TGFB1/FAM3C/TP53 3 GO:0048146 positive regulation of fibroblast proliferation 3/852 48/18722 0.374265989665894 0.623576118654372 FN1/FOSL2/MIF 3 GO:0090199 regulation of release of cytochrome c from mitochondria 3/852 48/18722 0.374265989665894 0.623576118654372 TNFSF10/PINK1/TP53 3 GO:0009247 glycolipid biosynthetic process 4/852 68/18722 0.374418245693128 0.623576118654372 UGCG/PIGT/B4GALT5/GPAA1 4 GO:0009988 cell-cell recognition 4/852 68/18722 0.374418245693128 0.623576118654372 CD9/B4GALT1/LY6K/LGALS3 4 GO:0051148 negative regulation of muscle cell differentiation 4/852 68/18722 0.374418245693128 0.623576118654372 IGF2/XBP1/BMPR2/HDAC5 4 GO:0006790 sulfur compound metabolic process 17/852 339/18722 0.375487325396649 0.625149754787077 BGN/CHPF/B3GNT7/PIPOX/UGDH/DSEL/TECR/CHPF2/ACSL4/ST3GAL6/GPX4/GNS/AMD1/DSE/GLB1/EXT2/ACSL3 17 GO:0015980 energy derivation by oxidation of organic compounds 16/852 318/18722 0.376150005009979 0.626045957412442 IGF2/IL6ST/PRKAG2/POMC/PHKG1/GAA/INSR/GFPT1/GBA/PINK1/OPN3/PPP1CB/PYGL/TP53/IFNAR1/UQCR11 16 GO:0032410 negative regulation of transporter activity 6/852 109/18722 0.376844534465212 0.626580291365515 RRAD/EPHB2/NDFIP2/NDFIP1/FMR1/SRI 6 GO:0032414 positive regulation of ion transmembrane transporter activity 6/852 109/18722 0.376844534465212 0.626580291365515 EPHB2/GLRX/IFNGR2/DNM2/PINK1/ACTN4 6 GO:0043266 regulation of potassium ion transport 6/852 109/18722 0.376844534465212 0.626580291365515 ITGB1/PTK2B/KCNJ2/FLNA/CD63/DNM2 6 GO:0032872 regulation of stress-activated MAPK cascade 10/852 192/18722 0.377003517467866 0.626637616715909 SFRP1/TGFB2/PTK2B/SEMA4C/SASH1/PINK1/MAPK3/HIPK3/EZR/EMC10 10 GO:0001916 positive regulation of T cell mediated cytotoxicity 2/852 29/18722 0.382831756971434 0.631574111801694 HLA-G/PVR 2 GO:0002360 T cell lineage commitment 2/852 29/18722 0.382831756971434 0.631574111801694 CTSL/TP53 2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/852 29/18722 0.382831756971434 0.631574111801694 PLK2/FURIN 2 GO:0006688 glycosphingolipid biosynthetic process 2/852 29/18722 0.382831756971434 0.631574111801694 UGCG/B4GALT5 2 GO:0009310 amine catabolic process 2/852 29/18722 0.382831756971434 0.631574111801694 MAOA/SAT1 2 GO:0021602 cranial nerve morphogenesis 2/852 29/18722 0.382831756971434 0.631574111801694 CITED2/EPHB2 2 GO:0022011 myelination in peripheral nervous system 2/852 29/18722 0.382831756971434 0.631574111801694 DAG1/NDRG1 2 GO:0031069 hair follicle morphogenesis 2/852 29/18722 0.382831756971434 0.631574111801694 TGFB2/CTNNB1 2 GO:0032292 peripheral nervous system axon ensheathment 2/852 29/18722 0.382831756971434 0.631574111801694 DAG1/NDRG1 2 GO:0035066 positive regulation of histone acetylation 2/852 29/18722 0.382831756971434 0.631574111801694 GATA3/MAPK3 2 GO:0043153 entrainment of circadian clock by photoperiod 2/852 29/18722 0.382831756971434 0.631574111801694 PPP1CB/TP53 2 GO:0062098 regulation of programmed necrotic cell death 2/852 29/18722 0.382831756971434 0.631574111801694 ARHGEF2/TP53 2 GO:0070979 protein K11-linked ubiquitination 2/852 29/18722 0.382831756971434 0.631574111801694 ANAPC13/UBE2A 2 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/852 29/18722 0.382831756971434 0.631574111801694 MIF/TP53 2 GO:2000406 positive regulation of T cell migration 2/852 29/18722 0.382831756971434 0.631574111801694 ADAM10/ADAM17 2 GO:0019226 transmission of nerve impulse 4/852 69/18722 0.384849559089748 0.631574111801694 CLDN19/GBA/P2RX4/FMR1 4 GO:0050688 regulation of defense response to virus 4/852 69/18722 0.384849559089748 0.631574111801694 HTRA1/TNFAIP3/SEC14L1/PCBP2 4 GO:1901224 positive regulation of NIK/NF-kappaB signaling 4/852 69/18722 0.384849559089748 0.631574111801694 SASH1/CALR/ACTN4/NFAT5 4 GO:0001913 T cell mediated cytotoxicity 3/852 49/18722 0.386759805280518 0.631574111801694 HLA-G/PVR/CTSH 3 GO:0002279 mast cell activation involved in immune response 3/852 49/18722 0.386759805280518 0.631574111801694 GATA2/SNAP23/S100A13 3 GO:0006953 acute-phase response 3/852 49/18722 0.386759805280518 0.631574111801694 FN1/PTGES/EDNRB 3 GO:0007622 rhythmic behavior 3/852 49/18722 0.386759805280518 0.631574111801694 NAGLU/EGR1/TP53 3 GO:0032692 negative regulation of interleukin-1 production 3/852 49/18722 0.386759805280518 0.631574111801694 IL1R2/TNFAIP3/ERRFI1 3 GO:0035088 establishment or maintenance of apical/basal cell polarity 3/852 49/18722 0.386759805280518 0.631574111801694 CLIC4/FAT1/ARF4 3 GO:0042304 regulation of fatty acid biosynthetic process 3/852 49/18722 0.386759805280518 0.631574111801694 APOC1/INSIG1/FABP5 3 GO:0042461 photoreceptor cell development 3/852 49/18722 0.386759805280518 0.631574111801694 MFSD2A/NAGLU/TUG1 3 GO:0043457 regulation of cellular respiration 3/852 49/18722 0.386759805280518 0.631574111801694 PINK1/OPN3/IFNAR1 3 GO:0048168 regulation of neuronal synaptic plasticity 3/852 49/18722 0.386759805280518 0.631574111801694 APOE/EPHB2/NPTN 3 GO:0052372 modulation by symbiont of entry into host 3/852 49/18722 0.386759805280518 0.631574111801694 P4HB/FUCA2/GSN 3 GO:0061245 establishment or maintenance of bipolar cell polarity 3/852 49/18722 0.386759805280518 0.631574111801694 CLIC4/FAT1/ARF4 3 GO:0070741 response to interleukin-6 3/852 49/18722 0.386759805280518 0.631574111801694 IL6ST/JAK1/ST3GAL6 3 GO:0072666 establishment of protein localization to vacuole 3/852 49/18722 0.386759805280518 0.631574111801694 TNFAIP3/SCARB2/LAMP2 3 GO:0086009 membrane repolarization 3/852 49/18722 0.386759805280518 0.631574111801694 KCNJ2/FLNA/GJA5 3 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 3/852 49/18722 0.386759805280518 0.631574111801694 HPGD/ADAMTS1/MMP2 3 GO:0006661 phosphatidylinositol biosynthetic process 7/852 131/18722 0.38729641323467 0.631574111801694 PIGT/IPMK/PIK3CB/INPPL1/PIK3R1/GPAA1/IMPA2 7 GO:0016573 histone acetylation 8/852 152/18722 0.388553805536423 0.631574111801694 GATA3/GATA2/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 8 GO:0031056 regulation of histone modification 8/852 152/18722 0.388553805536423 0.631574111801694 IGF2/GATA3/GATA2/CTNNB1/PINK1/MAPK3/TP53/FMR1 8 GO:0034765 regulation of ion transmembrane transport 24/852 491/18722 0.38860790513624 0.631574111801694 RRAD/ITGB1/FXYD5/RASGRF2/KCNK12/PTK2B/EPHB2/KCNJ2/SESTD1/FLNA/GLRX/CD63/CLIC4/IFNGR2/DNM2/GJA5/UBASH3B/DAPK1/PINK1/ACTN4/PTPN3/AHNAK/FMR1/SRI 24 GO:0045165 cell fate commitment 13/852 258/18722 0.393481522259145 0.631574111801694 EPAS1/ITGB1/SFRP1/TCF7L2/GATA3/GCM1/GATA2/CTSL/NOTCH2/ARHGEF2/CTNNB1/TP53/ETS2 13 GO:0003407 neural retina development 4/852 70/18722 0.395259240461054 0.631574111801694 PTN/TGFB2/NAGLU/OBSL1 4 GO:0030705 cytoskeleton-dependent intracellular transport 10/852 195/18722 0.395465157486128 0.631574111801694 HSPB1/MYO10/AP3S1/LAMP1/MYO6/ACTN4/SUN2/COPG1/ARL8B/MYO1C 10 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 2/852 30/18722 0.399146947629701 0.631574111801694 DNASE1L3/ENDOG 2 GO:0017145 stem cell division 2/852 30/18722 0.399146947629701 0.631574111801694 WWTR1/TGFB2 2 GO:0034694 response to prostaglandin 2/852 30/18722 0.399146947629701 0.631574111801694 SFRP1/TGFBR3 2 GO:0045070 positive regulation of viral genome replication 2/852 30/18722 0.399146947629701 0.631574111801694 PABPC1/DDB1 2 GO:0045939 negative regulation of steroid metabolic process 2/852 30/18722 0.399146947629701 0.631574111801694 APOE/INSIG1 2 GO:0048147 negative regulation of fibroblast proliferation 2/852 30/18722 0.399146947629701 0.631574111801694 SFRP1/TP53 2 GO:0051125 regulation of actin nucleation 2/852 30/18722 0.399146947629701 0.631574111801694 NCKAP1/GSN 2 GO:0051491 positive regulation of filopodium assembly 2/852 30/18722 0.399146947629701 0.631574111801694 PIK3R1/FMR1 2 GO:0060218 hematopoietic stem cell differentiation 2/852 30/18722 0.399146947629701 0.631574111801694 SFRP1/TP53 2 GO:0060351 cartilage development involved in endochondral bone morphogenesis 2/852 30/18722 0.399146947629701 0.631574111801694 COL27A1/SERPINH1 2 GO:0090314 positive regulation of protein targeting to membrane 2/852 30/18722 0.399146947629701 0.631574111801694 ERBB2/MYO1C 2 GO:1903579 negative regulation of ATP metabolic process 2/852 30/18722 0.399146947629701 0.631574111801694 TSPO/TP53 2 GO:2000648 positive regulation of stem cell proliferation 2/852 30/18722 0.399146947629701 0.631574111801694 LTBP3/CCNE1 2 GO:0001961 positive regulation of cytokine-mediated signaling pathway 3/852 50/18722 0.399193047390516 0.631574111801694 IL1R1/UBE2K/ADAM17 3 GO:0002448 mast cell mediated immunity 3/852 50/18722 0.399193047390516 0.631574111801694 GATA2/SNAP23/S100A13 3 GO:0002639 positive regulation of immunoglobulin production 3/852 50/18722 0.399193047390516 0.631574111801694 TGFB1/EPHB2/XBP1 3 GO:0007632 visual behavior 3/852 50/18722 0.399193047390516 0.631574111801694 ITGB1/ABCA7/NPTN 3 GO:0008089 anterograde axonal transport 3/852 50/18722 0.399193047390516 0.631574111801694 HSPB1/AP3S1/ARL8B 3 GO:0010665 regulation of cardiac muscle cell apoptotic process 3/852 50/18722 0.399193047390516 0.631574111801694 CAPN2/TP53/MDK 3 GO:0015872 dopamine transport 3/852 50/18722 0.399193047390516 0.631574111801694 SYT8/SLC6A2/PINK1 3 GO:0042572 retinol metabolic process 3/852 50/18722 0.399193047390516 0.631574111801694 TTR/DHRS3/RDH10 3 GO:0043268 positive regulation of potassium ion transport 3/852 50/18722 0.399193047390516 0.631574111801694 KCNJ2/FLNA/DNM2 3 GO:0090102 cochlea development 3/852 50/18722 0.399193047390516 0.631574111801694 GATA3/GATA2/ADAM10 3 GO:1902930 regulation of alcohol biosynthetic process 3/852 50/18722 0.399193047390516 0.631574111801694 PTK2B/APOE/H6PD 3 GO:0002275 myeloid cell activation involved in immune response 5/852 91/18722 0.399391693189829 0.631574111801694 DNASE1L3/GATA2/GRN/SNAP23/S100A13 5 GO:0045582 positive regulation of T cell differentiation 5/852 91/18722 0.399391693189829 0.631574111801694 HLA-G/GATA3/SOX4/XBP1/MDK 5 GO:0051259 protein complex oligomerization 12/852 238/18722 0.399888061674014 0.631574111801694 HLA-G/UGDH/KCNJ2/ATL3/ISG15/VASP/SLC1A5/GLS/EVL/MIF/TP53/KRT10 12 GO:0001731 formation of translation preinitiation complex 1/852 11/18722 0.400989306556724 0.631574111801694 EIF4B 1 GO:0001765 membrane raft assembly 1/852 11/18722 0.400989306556724 0.631574111801694 CAV2 1 GO:0001787 natural killer cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 ELF4 1 GO:0001867 complement activation, lectin pathway 1/852 11/18722 0.400989306556724 0.631574111801694 SERPING1 1 GO:0001967 suckling behavior 1/852 11/18722 0.400989306556724 0.631574111801694 GLS 1 GO:0002357 defense response to tumor cell 1/852 11/18722 0.400989306556724 0.631574111801694 DAPK1 1 GO:0003093 regulation of glomerular filtration 1/852 11/18722 0.400989306556724 0.631574111801694 GJA5 1 GO:0003263 cardioblast proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0003264 regulation of cardioblast proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0006002 fructose 6-phosphate metabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 GFPT1 1 GO:0006020 inositol metabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 IMPA2 1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1/852 11/18722 0.400989306556724 0.631574111801694 UQCR11 1 GO:0006971 hypotonic response 1/852 11/18722 0.400989306556724 0.631574111801694 TSPO 1 GO:0010739 positive regulation of protein kinase A signaling 1/852 11/18722 0.400989306556724 0.631574111801694 MIF 1 GO:0010887 negative regulation of cholesterol storage 1/852 11/18722 0.400989306556724 0.631574111801694 ABCA1 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/852 11/18722 0.400989306556724 0.631574111801694 LIPG 1 GO:0014010 Schwann cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 ASCL2 1 GO:0015886 heme transport 1/852 11/18722 0.400989306556724 0.631574111801694 PGRMC2 1 GO:0021702 cerebellar Purkinje cell differentiation 1/852 11/18722 0.400989306556724 0.631574111801694 HERC1 1 GO:0030210 heparin biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 EXT2 1 GO:0030656 regulation of vitamin metabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 RDH10 1 GO:0032276 regulation of gonadotropin secretion 1/852 11/18722 0.400989306556724 0.631574111801694 INHA 1 GO:0032836 glomerular basement membrane development 1/852 11/18722 0.400989306556724 0.631574111801694 LAMB2 1 GO:0033083 regulation of immature T cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 ERBB2 1 GO:0033234 negative regulation of protein sumoylation 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0033327 Leydig cell differentiation 1/852 11/18722 0.400989306556724 0.631574111801694 PLEKHA1 1 GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/852 11/18722 0.400989306556724 0.631574111801694 DPP4 1 GO:0033860 regulation of NAD(P)H oxidase activity 1/852 11/18722 0.400989306556724 0.631574111801694 RFK 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/852 11/18722 0.400989306556724 0.631574111801694 MYADM 1 GO:0034776 response to histamine 1/852 11/18722 0.400989306556724 0.631574111801694 AOC1 1 GO:0034969 histone arginine methylation 1/852 11/18722 0.400989306556724 0.631574111801694 CARM1 1 GO:0035246 peptidyl-arginine N-methylation 1/852 11/18722 0.400989306556724 0.631574111801694 CARM1 1 GO:0035766 cell chemotaxis to fibroblast growth factor 1/852 11/18722 0.400989306556724 0.631574111801694 FGFR1 1 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/852 11/18722 0.400989306556724 0.631574111801694 SEC14L1 1 GO:0042135 neurotransmitter catabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 MAOA 1 GO:0042416 dopamine biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB2 1 GO:0042447 hormone catabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 DIO2 1 GO:0042451 purine nucleoside biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 AMD1 1 GO:0042455 ribonucleoside biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 AMD1 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/852 11/18722 0.400989306556724 0.631574111801694 GATA2 1 GO:0045657 positive regulation of monocyte differentiation 1/852 11/18722 0.400989306556724 0.631574111801694 ZFP36L1 1 GO:0046129 purine ribonucleoside biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 AMD1 1 GO:0046598 positive regulation of viral entry into host cell 1/852 11/18722 0.400989306556724 0.631574111801694 P4HB 1 GO:0046643 regulation of gamma-delta T cell activation 1/852 11/18722 0.400989306556724 0.631574111801694 SOX4 1 GO:0046710 GDP metabolic process 1/852 11/18722 0.400989306556724 0.631574111801694 TJP2 1 GO:0046929 negative regulation of neurotransmitter secretion 1/852 11/18722 0.400989306556724 0.631574111801694 FMR1 1 GO:0046940 nucleoside monophosphate phosphorylation 1/852 11/18722 0.400989306556724 0.631574111801694 CMPK1 1 GO:0048103 somatic stem cell division 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB2 1 GO:0048635 negative regulation of muscle organ development 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB1 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0051081 nuclear membrane disassembly 1/852 11/18722 0.400989306556724 0.631574111801694 CTDNEP1 1 GO:0051798 positive regulation of hair follicle development 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB2 1 GO:0055015 ventricular cardiac muscle cell development 1/852 11/18722 0.400989306556724 0.631574111801694 FHL2 1 GO:0060159 regulation of dopamine receptor signaling pathway 1/852 11/18722 0.400989306556724 0.631574111801694 CAV2 1 GO:0060174 limb bud formation 1/852 11/18722 0.400989306556724 0.631574111801694 SOX4 1 GO:0060312 regulation of blood vessel remodeling 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB1 1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/852 11/18722 0.400989306556724 0.631574111801694 SRI 1 GO:0060746 parental behavior 1/852 11/18722 0.400989306556724 0.631574111801694 MBD2 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0061314 Notch signaling involved in heart development 1/852 11/18722 0.400989306556724 0.631574111801694 NOTCH2 1 GO:0061635 regulation of protein complex stability 1/852 11/18722 0.400989306556724 0.631574111801694 TAPBP 1 GO:0070327 thyroid hormone transport 1/852 11/18722 0.400989306556724 0.631574111801694 TTR 1 GO:0070341 fat cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 GATA2 1 GO:0070344 regulation of fat cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 GATA2 1 GO:0070417 cellular response to cold 1/852 11/18722 0.400989306556724 0.631574111801694 DNAJC3 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/852 11/18722 0.400989306556724 0.631574111801694 MYADM 1 GO:0070601 centromeric sister chromatid cohesion 1/852 11/18722 0.400989306556724 0.631574111801694 CTNNB1 1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 1/852 11/18722 0.400989306556724 0.631574111801694 PTN 1 GO:0071888 macrophage apoptotic process 1/852 11/18722 0.400989306556724 0.631574111801694 CTSL 1 GO:0072110 glomerular mesangial cell proliferation 1/852 11/18722 0.400989306556724 0.631574111801694 EGR1 1 GO:0072697 protein localization to cell cortex 1/852 11/18722 0.400989306556724 0.631574111801694 EZR 1 GO:0075294 positive regulation by symbiont of entry into host 1/852 11/18722 0.400989306556724 0.631574111801694 P4HB 1 GO:0075522 IRES-dependent viral translational initiation 1/852 11/18722 0.400989306556724 0.631574111801694 PCBP2 1 GO:0086016 AV node cell action potential 1/852 11/18722 0.400989306556724 0.631574111801694 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/852 11/18722 0.400989306556724 0.631574111801694 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/852 11/18722 0.400989306556724 0.631574111801694 GJA5 1 GO:0090030 regulation of steroid hormone biosynthetic process 1/852 11/18722 0.400989306556724 0.631574111801694 H6PD 1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1/852 11/18722 0.400989306556724 0.631574111801694 SFRP1 1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/852 11/18722 0.400989306556724 0.631574111801694 SLC35A3 1 GO:0097104 postsynaptic membrane assembly 1/852 11/18722 0.400989306556724 0.631574111801694 EPHB2 1 GO:0097494 regulation of vesicle size 1/852 11/18722 0.400989306556724 0.631574111801694 PICALM 1 GO:0098792 xenophagy 1/852 11/18722 0.400989306556724 0.631574111801694 MAPK3 1 GO:0099624 atrial cardiac muscle cell membrane repolarization 1/852 11/18722 0.400989306556724 0.631574111801694 FLNA 1 GO:1900426 positive regulation of defense response to bacterium 1/852 11/18722 0.400989306556724 0.631574111801694 GRN 1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1/852 11/18722 0.400989306556724 0.631574111801694 SRI 1 GO:1901862 negative regulation of muscle tissue development 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB1 1 GO:1902065 response to L-glutamate 1/852 11/18722 0.400989306556724 0.631574111801694 TMBIM6 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/852 11/18722 0.400989306556724 0.631574111801694 TGFB2 1 GO:1902510 regulation of apoptotic DNA fragmentation 1/852 11/18722 0.400989306556724 0.631574111801694 ENDOG 1 GO:1903423 positive regulation of synaptic vesicle recycling 1/852 11/18722 0.400989306556724 0.631574111801694 SH3GL1 1 GO:1903961 positive regulation of anion transmembrane transport 1/852 11/18722 0.400989306556724 0.631574111801694 ITGB1 1 GO:1904181 positive regulation of membrane depolarization 1/852 11/18722 0.400989306556724 0.631574111801694 TSPO 1 GO:1904847 regulation of cell chemotaxis to fibroblast growth factor 1/852 11/18722 0.400989306556724 0.631574111801694 FGFR1 1 GO:1905522 negative regulation of macrophage migration 1/852 11/18722 0.400989306556724 0.631574111801694 MIF 1 GO:1905668 positive regulation of protein localization to endosome 1/852 11/18722 0.400989306556724 0.631574111801694 EZR 1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/852 11/18722 0.400989306556724 0.631574111801694 ADAM19 1 GO:2000615 regulation of histone H3-K9 acetylation 1/852 11/18722 0.400989306556724 0.631574111801694 GATA3 1 GO:2000786 positive regulation of autophagosome assembly 1/852 11/18722 0.400989306556724 0.631574111801694 SH3GLB1 1 GO:0001676 long-chain fatty acid metabolic process 6/852 112/18722 0.401431667723747 0.631574111801694 PAM/MGLL/ACSL4/MAPK3/GPX4/ACSL3 6 GO:0002821 positive regulation of adaptive immune response 6/852 112/18722 0.401431667723747 0.631574111801694 IL6ST/HLA-G/IL1R1/GATA3/TGFB1/PVR 6 GO:0010633 negative regulation of epithelial cell migration 6/852 112/18722 0.401431667723747 0.631574111801694 ACVRL1/TGFB1/APOE/HDAC5/EVL/JUP 6 GO:0032609 interferon-gamma production 6/852 112/18722 0.401431667723747 0.631574111801694 EBI3/IL1R1/GATA3/CD276/INHA/ISG15 6 GO:0032649 regulation of interferon-gamma production 6/852 112/18722 0.401431667723747 0.631574111801694 EBI3/IL1R1/GATA3/CD276/INHA/ISG15 6 GO:0009855 determination of bilateral symmetry 7/852 133/18722 0.402312273703144 0.632761772983727 ENG/CITED2/SMAD3/PCSK6/NOTCH2/TMED2/CTNNB1 7 GO:0007605 sensory perception of sound 8/852 154/18722 0.402489457110614 0.632842685922436 HEXB/NAV2/WFS1/SCARB2/MYO6/SLC1A3/SERPINB6/EPS8L2 8 GO:0071347 cellular response to interleukin-1 6/852 113/18722 0.409618018413737 0.643560519552772 IL1R1/TFPI/SFRP1/IL1R2/EGR1/MAPK3 6 GO:0002705 positive regulation of leukocyte mediated immunity 7/852 134/18722 0.4098174975495 0.643560519552772 HLA-G/IL1R1/GATA3/TGFB1/PVR/LAMP1/AP1G1 7 GO:0009799 specification of symmetry 7/852 134/18722 0.4098174975495 0.643560519552772 ENG/CITED2/SMAD3/PCSK6/NOTCH2/TMED2/CTNNB1 7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7/852 134/18722 0.4098174975495 0.643560519552772 PLK2/GBA/ANKIB1/HERPUD1/RNF144B/CSNK1A1/UBE2K 7 GO:0051293 establishment of spindle localization 3/852 51/18722 0.411555456910032 0.64548414291935 ITGB1/MYH9/MAP4 3 GO:0051339 regulation of lyase activity 3/852 51/18722 0.411555456910032 0.64548414291935 TIMP2/GUCA2A/EDNRB 3 GO:0060043 regulation of cardiac muscle cell proliferation 3/852 51/18722 0.411555456910032 0.64548414291935 NOG/CITED2/TGFBR3 3 GO:1903307 positive regulation of regulated secretory pathway 3/852 51/18722 0.411555456910032 0.64548414291935 GATA2/LAMP1/AP1G1 3 GO:0009636 response to toxic substance 13/852 262/18722 0.414907797089192 0.647287762325608 PTGES/MT1X/APOE/RALBP1/GLRX/PRDX4/SOD3/GPX8/SDC1/PINK1/TXN/MAPK3/GPX4 13 GO:0001782 B cell homeostasis 2/852 31/18722 0.41525723075238 0.647287762325608 TNFAIP3/PKN1 2 GO:0002323 natural killer cell activation involved in immune response 2/852 31/18722 0.41525723075238 0.647287762325608 LAMP1/AP1G1 2 GO:0002828 regulation of type 2 immune response 2/852 31/18722 0.41525723075238 0.647287762325608 GATA3/NDFIP1 2 GO:0006301 postreplication repair 2/852 31/18722 0.41525723075238 0.647287762325608 UBE2A/FAAP20 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/852 31/18722 0.41525723075238 0.647287762325608 TSPO/PGRMC1 2 GO:0008045 motor neuron axon guidance 2/852 31/18722 0.41525723075238 0.647287762325608 NOG/ERBB2 2 GO:0031063 regulation of histone deacetylation 2/852 31/18722 0.41525723075238 0.647287762325608 PINK1/TP53 2 GO:0033014 tetrapyrrole biosynthetic process 2/852 31/18722 0.41525723075238 0.647287762325608 TSPO/PGRMC1 2 GO:0035510 DNA dealkylation 2/852 31/18722 0.41525723075238 0.647287762325608 GATA3/TET3 2 GO:0045066 regulatory T cell differentiation 2/852 31/18722 0.41525723075238 0.647287762325608 HLA-G/MDK 2 GO:0051569 regulation of histone H3-K4 methylation 2/852 31/18722 0.41525723075238 0.647287762325608 GATA3/CTNNB1 2 GO:0055022 negative regulation of cardiac muscle tissue growth 2/852 31/18722 0.41525723075238 0.647287762325608 NOG/CITED2 2 GO:0055075 potassium ion homeostasis 2/852 31/18722 0.41525723075238 0.647287762325608 SLC12A8/KCNJ2 2 GO:0060795 cell fate commitment involved in formation of primary germ layer 2/852 31/18722 0.41525723075238 0.647287762325608 CTNNB1/ETS2 2 GO:0061117 negative regulation of heart growth 2/852 31/18722 0.41525723075238 0.647287762325608 NOG/CITED2 2 GO:0071480 cellular response to gamma radiation 2/852 31/18722 0.41525723075238 0.647287762325608 EGR1/TP53 2 GO:0097106 postsynaptic density organization 2/852 31/18722 0.41525723075238 0.647287762325608 IL1RAP/PTPRS 2 GO:1900027 regulation of ruffle assembly 2/852 31/18722 0.41525723075238 0.647287762325608 EVL/EPS8L2 2 GO:0098739 import across plasma membrane 9/852 177/18722 0.415277604718734 0.647287762325608 ITGB1/SLC39A6/SLC12A8/SLC39A8/SLC7A1/KCNJ2/SLC1A5/SLC15A3/SLC1A3 9 GO:0002534 cytokine production involved in inflammatory response 4/852 72/18722 0.415987064548624 0.647391124265066 IL1R2/PLD3/ADCY7/CHID1 4 GO:0032729 positive regulation of interferon-gamma production 4/852 72/18722 0.415987064548624 0.647391124265066 EBI3/IL1R1/CD276/ISG15 4 GO:0051057 positive regulation of small GTPase mediated signal transduction 4/852 72/18722 0.415987064548624 0.647391124265066 F11R/MAPRE2/NOTCH2/PIK3CB 4 GO:1900015 regulation of cytokine production involved in inflammatory response 4/852 72/18722 0.415987064548624 0.647391124265066 IL1R2/PLD3/ADCY7/CHID1 4 GO:1901880 negative regulation of protein depolymerization 4/852 72/18722 0.415987064548624 0.647391124265066 CAPG/LIMA1/ARHGEF2/GSN 4 GO:0007589 body fluid secretion 5/852 93/18722 0.417556989568074 0.648754683218606 PAM/XBP1/NCOR2/NCOA1/COPA 5 GO:0019217 regulation of fatty acid metabolic process 5/852 93/18722 0.417556989568074 0.648754683218606 PRKAG2/APOC1/MFSD2A/INSIG1/FABP5 5 GO:0019751 polyol metabolic process 6/852 114/18722 0.417793970036911 0.648754683218606 PTK2B/IPMK/PLPP3/SGPP1/GBA/IMPA2 6 GO:0046660 female sex differentiation 6/852 114/18722 0.417793970036911 0.648754683218606 NRIP1/SFRP1/ADAMTS1/INHA/MMP14/PLEKHA1 6 GO:1903008 organelle disassembly 6/852 114/18722 0.417793970036911 0.648754683218606 TSPO/WIPI1/GBA/PINK1/CTTN/TP53 6 GO:0035265 organ growth 9/852 178/18722 0.421808239860821 0.648754683218606 IGF2/NOG/CITED2/PDLIM5/PSAP/COL27A1/TGFB2/WWC3/TGFBR3 9 GO:2000377 regulation of reactive oxygen species metabolic process 8/852 157/18722 0.423387612003247 0.648754683218606 PRCP/TSPO/TGFB1/PTK2B/PINK1/MYCN/ARF4/TP53 8 GO:0010662 regulation of striated muscle cell apoptotic process 3/852 52/18722 0.423837371770138 0.648754683218606 CAPN2/TP53/MDK 3 GO:0032206 positive regulation of telomere maintenance 3/852 52/18722 0.423837371770138 0.648754683218606 TNKS2/CTNNB1/MAPK3 3 GO:0043277 apoptotic cell clearance 3/852 52/18722 0.423837371770138 0.648754683218606 ABCA7/SCARB1/LRP1 3 GO:0045010 actin nucleation 3/852 52/18722 0.423837371770138 0.648754683218606 NCKAP1/EVL/GSN 3 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 3/852 52/18722 0.423837371770138 0.648754683218606 SFRP1/GPC4/TIAM1 3 GO:2000378 negative regulation of reactive oxygen species metabolic process 3/852 52/18722 0.423837371770138 0.648754683218606 PINK1/MYCN/TP53 3 GO:0051145 smooth muscle cell differentiation 4/852 73/18722 0.426292508950371 0.648754683218606 ENG/ADM/EDNRB/CTNNB1 4 GO:0051937 catecholamine transport 4/852 73/18722 0.426292508950371 0.648754683218606 SYT8/SLC6A2/ACTB/PINK1 4 GO:0099518 vesicle cytoskeletal trafficking 4/852 73/18722 0.426292508950371 0.648754683218606 AP3S1/MYO6/ACTN4/MYO1C 4 GO:0072522 purine-containing compound biosynthetic process 10/852 200/18722 0.426305681320852 0.648754683218606 PRKAG2/GUCA2A/TGFB1/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/AMD1/ACSL3 10 GO:0001821 histamine secretion 1/852 12/18722 0.428265086088212 0.648754683218606 SNAP23 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/852 12/18722 0.428265086088212 0.648754683218606 NAV2 1 GO:0002328 pro-B cell differentiation 1/852 12/18722 0.428265086088212 0.648754683218606 SOX4 1 GO:0003207 cardiac chamber formation 1/852 12/18722 0.428265086088212 0.648754683218606 SOX4 1 GO:0003306 Wnt signaling pathway involved in heart development 1/852 12/18722 0.428265086088212 0.648754683218606 CTNNB1 1 GO:0006563 L-serine metabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 SERINC3 1 GO:0006703 estrogen biosynthetic process 1/852 12/18722 0.428265086088212 0.648754683218606 HSD3B1 1 GO:0007320 insemination 1/852 12/18722 0.428265086088212 0.648754683218606 SERPINE2 1 GO:0010459 negative regulation of heart rate 1/852 12/18722 0.428265086088212 0.648754683218606 SRI 1 GO:0010587 miRNA catabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 KCNQ1OT1 1 GO:0010623 programmed cell death involved in cell development 1/852 12/18722 0.428265086088212 0.648754683218606 DNASE1L3 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/852 12/18722 0.428265086088212 0.648754683218606 LRP1 1 GO:0014889 muscle atrophy 1/852 12/18722 0.428265086088212 0.648754683218606 GSN 1 GO:0015780 nucleotide-sugar transmembrane transport 1/852 12/18722 0.428265086088212 0.648754683218606 SLC35A3 1 GO:0016188 synaptic vesicle maturation 1/852 12/18722 0.428265086088212 0.648754683218606 PICALM 1 GO:0030157 pancreatic juice secretion 1/852 12/18722 0.428265086088212 0.648754683218606 COPA 1 GO:0030202 heparin metabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 EXT2 1 GO:0030259 lipid glycosylation 1/852 12/18722 0.428265086088212 0.648754683218606 GBA 1 GO:0030397 membrane disassembly 1/852 12/18722 0.428265086088212 0.648754683218606 CTDNEP1 1 GO:0031223 auditory behavior 1/852 12/18722 0.428265086088212 0.648754683218606 SLC1A3 1 GO:0032096 negative regulation of response to food 1/852 12/18722 0.428265086088212 0.648754683218606 NUCB2 1 GO:0032099 negative regulation of appetite 1/852 12/18722 0.428265086088212 0.648754683218606 NUCB2 1 GO:0032105 negative regulation of response to extracellular stimulus 1/852 12/18722 0.428265086088212 0.648754683218606 NUCB2 1 GO:0032108 negative regulation of response to nutrient levels 1/852 12/18722 0.428265086088212 0.648754683218606 NUCB2 1 GO:0032490 detection of molecule of bacterial origin 1/852 12/18722 0.428265086088212 0.648754683218606 SCARB1 1 GO:0032536 regulation of cell projection size 1/852 12/18722 0.428265086088212 0.648754683218606 EZR 1 GO:0032908 regulation of transforming growth factor beta1 production 1/852 12/18722 0.428265086088212 0.648754683218606 FURIN 1 GO:0032926 negative regulation of activin receptor signaling pathway 1/852 12/18722 0.428265086088212 0.648754683218606 FSTL3 1 GO:0033079 immature T cell proliferation 1/852 12/18722 0.428265086088212 0.648754683218606 ERBB2 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/852 12/18722 0.428265086088212 0.648754683218606 ACOX1 1 GO:0033629 negative regulation of cell adhesion mediated by integrin 1/852 12/18722 0.428265086088212 0.648754683218606 SERPINE1 1 GO:0035112 genitalia morphogenesis 1/852 12/18722 0.428265086088212 0.648754683218606 CTNNB1 1 GO:0035933 glucocorticoid secretion 1/852 12/18722 0.428265086088212 0.648754683218606 POMC 1 GO:0038203 TORC2 signaling 1/852 12/18722 0.428265086088212 0.648754683218606 PINK1 1 GO:0042118 endothelial cell activation 1/852 12/18722 0.428265086088212 0.648754683218606 P2RX4 1 GO:0045117 azole transmembrane transport 1/852 12/18722 0.428265086088212 0.648754683218606 SLC7A1 1 GO:0046322 negative regulation of fatty acid oxidation 1/852 12/18722 0.428265086088212 0.648754683218606 MFSD2A 1 GO:0051095 regulation of helicase activity 1/852 12/18722 0.428265086088212 0.648754683218606 TP53 1 GO:0051255 spindle midzone assembly 1/852 12/18722 0.428265086088212 0.648754683218606 CCDC69 1 GO:0051583 dopamine uptake involved in synaptic transmission 1/852 12/18722 0.428265086088212 0.648754683218606 SLC6A2 1 GO:0051639 actin filament network formation 1/852 12/18722 0.428265086088212 0.648754683218606 ACTN1 1 GO:0051934 catecholamine uptake involved in synaptic transmission 1/852 12/18722 0.428265086088212 0.648754683218606 SLC6A2 1 GO:0060442 branching involved in prostate gland morphogenesis 1/852 12/18722 0.428265086088212 0.648754683218606 SFRP1 1 GO:0060601 lateral sprouting from an epithelium 1/852 12/18722 0.428265086088212 0.648754683218606 NOG 1 GO:0060788 ectodermal placode formation 1/852 12/18722 0.428265086088212 0.648754683218606 CTNNB1 1 GO:0070213 protein auto-ADP-ribosylation 1/852 12/18722 0.428265086088212 0.648754683218606 TNKS2 1 GO:0070493 thrombin-activated receptor signaling pathway 1/852 12/18722 0.428265086088212 0.648754683218606 HPGD 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/852 12/18722 0.428265086088212 0.648754683218606 MYADM 1 GO:0071697 ectodermal placode morphogenesis 1/852 12/18722 0.428265086088212 0.648754683218606 CTNNB1 1 GO:0071712 ER-associated misfolded protein catabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 SDF2L1 1 GO:0072584 caveolin-mediated endocytosis 1/852 12/18722 0.428265086088212 0.648754683218606 MAPK3 1 GO:0072683 T cell extravasation 1/852 12/18722 0.428265086088212 0.648754683218606 F11R 1 GO:0086067 AV node cell to bundle of His cell communication 1/852 12/18722 0.428265086088212 0.648754683218606 GJA5 1 GO:0090177 establishment of planar polarity involved in neural tube closure 1/852 12/18722 0.428265086088212 0.648754683218606 SFRP1 1 GO:0090385 phagosome-lysosome fusion 1/852 12/18722 0.428265086088212 0.648754683218606 ARL8B 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/852 12/18722 0.428265086088212 0.648754683218606 ACTB 1 GO:0150065 regulation of deacetylase activity 1/852 12/18722 0.428265086088212 0.648754683218606 PINK1 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/852 12/18722 0.428265086088212 0.648754683218606 PLXNB2 1 GO:1902563 regulation of neutrophil activation 1/852 12/18722 0.428265086088212 0.648754683218606 GRN 1 GO:1902950 regulation of dendritic spine maintenance 1/852 12/18722 0.428265086088212 0.648754683218606 APOE 1 GO:1903332 regulation of protein folding 1/852 12/18722 0.428265086088212 0.648754683218606 GRN 1 GO:1903624 regulation of DNA catabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 ENDOG 1 GO:1904748 regulation of apoptotic process involved in development 1/852 12/18722 0.428265086088212 0.648754683218606 TGFB2 1 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1/852 12/18722 0.428265086088212 0.648754683218606 CTNNB1 1 GO:1905205 positive regulation of connective tissue replacement 1/852 12/18722 0.428265086088212 0.648754683218606 PPP3CA 1 GO:2000009 negative regulation of protein localization to cell surface 1/852 12/18722 0.428265086088212 0.648754683218606 PICALM 1 GO:2000508 regulation of dendritic cell chemotaxis 1/852 12/18722 0.428265086088212 0.648754683218606 CALR 1 GO:2000628 regulation of miRNA metabolic process 1/852 12/18722 0.428265086088212 0.648754683218606 KCNQ1OT1 1 GO:2000727 positive regulation of cardiac muscle cell differentiation 1/852 12/18722 0.428265086088212 0.648754683218606 TGFB1 1 GO:2001214 positive regulation of vasculogenesis 1/852 12/18722 0.428265086088212 0.648754683218606 ADM 1 GO:0007416 synapse assembly 9/852 179/18722 0.428335349162613 0.648754683218606 IL1RAP/PDLIM5/PLXNB2/PTPRS/GPC4/EPHB2/TPBG/NPTN/OBSL1 9 GO:0007626 locomotory behavior 9/852 179/18722 0.428335349162613 0.648754683218606 HEXB/APOE/GAA/NAV2/RCAN1/NAGLU/EGR1/ARCN1/DPP4 9 GO:0018393 internal peptidyl-lysine acetylation 8/852 158/18722 0.430343703629627 0.650274253966519 GATA3/GATA2/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 8 GO:0006308 DNA catabolic process 2/852 32/18722 0.431147463835937 0.650274253966519 DNASE1L3/ENDOG 2 GO:0006506 GPI anchor biosynthetic process 2/852 32/18722 0.431147463835937 0.650274253966519 PIGT/GPAA1 2 GO:0010743 regulation of macrophage derived foam cell differentiation 2/852 32/18722 0.431147463835937 0.650274253966519 LPL/ABCA1 2 GO:0033687 osteoblast proliferation 2/852 32/18722 0.431147463835937 0.650274253966519 SFRP1/SMAD3 2 GO:0042044 fluid transport 2/852 32/18722 0.431147463835937 0.650274253966519 EDNRB/EXT2 2 GO:0042219 cellular modified amino acid catabolic process 2/852 32/18722 0.431147463835937 0.650274253966519 DIO2/PCYOX1 2 GO:0045761 regulation of adenylate cyclase activity 2/852 32/18722 0.431147463835937 0.650274253966519 TIMP2/EDNRB 2 GO:0045879 negative regulation of smoothened signaling pathway 2/852 32/18722 0.431147463835937 0.650274253966519 SERPINE2/HERC4 2 GO:0050850 positive regulation of calcium-mediated signaling 2/852 32/18722 0.431147463835937 0.650274253966519 P2RX4/CAMTA1 2 GO:0051642 centrosome localization 2/852 32/18722 0.431147463835937 0.650274253966519 SUN2/EZR 2 GO:0090022 regulation of neutrophil chemotaxis 2/852 32/18722 0.431147463835937 0.650274253966519 MDK/DPP4 2 GO:1900745 positive regulation of p38MAPK cascade 2/852 32/18722 0.431147463835937 0.650274253966519 SASH1/EMC10 2 GO:2000191 regulation of fatty acid transport 2/852 32/18722 0.431147463835937 0.650274253966519 PTGES/P2RX4 2 GO:0006720 isoprenoid metabolic process 6/852 116/18722 0.434101461938301 0.65453345054987 TTR/CRABP2/NPC2/DHRS3/LRP1/RDH10 6 GO:0071897 DNA biosynthetic process 9/852 180/18722 0.434857203187655 0.655476580905502 ACVRL1/PTK2B/TNKS2/BMPR2/GRHL2/CTNNB1/MAPK3/TP53/FAAP20 9 GO:0045666 positive regulation of neuron differentiation 5/852 95/18722 0.435629274973771 0.655868964355903 TIMP2/FGFR1/GATA2/ARHGEF2/NCOA1 5 GO:1901379 regulation of potassium ion transmembrane transport 5/852 95/18722 0.435629274973771 0.655868964355903 ITGB1/KCNJ2/FLNA/CD63/DNM2 5 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5/852 95/18722 0.435629274973771 0.655868964355903 TSPO/SOX4/ISG15/TNFAIP3/CTNNB1 5 GO:0032210 regulation of telomere maintenance via telomerase 3/852 53/18722 0.436029714829099 0.655868964355903 TNKS2/CTNNB1/MAPK3 3 GO:0033059 cellular pigmentation 3/852 53/18722 0.436029714829099 0.655868964355903 POMC/CD63/AP1G1 3 GO:0071320 cellular response to cAMP 3/852 53/18722 0.436029714829099 0.655868964355903 ZFP36L1/ITPR2/EZR 3 GO:0071715 icosanoid transport 3/852 53/18722 0.436029714829099 0.655868964355903 PTGES/SLCO2A1/P2RX4 3 GO:0002437 inflammatory response to antigenic stimulus 4/852 74/18722 0.436550927060168 0.656064740487855 GATA3/NOTCH2/PLK2/FURIN 4 GO:0006801 superoxide metabolic process 4/852 74/18722 0.436550927060168 0.656064740487855 SH3PXD2A/SH3PXD2B/TGFB1/SOD3 4 GO:0010822 positive regulation of mitochondrion organization 4/852 74/18722 0.436550927060168 0.656064740487855 TNFSF10/RALBP1/PINK1/TP53 4 GO:0046488 phosphatidylinositol metabolic process 8/852 159/18722 0.437291348181239 0.656981300118261 CSF1R/PIGT/IPMK/PIK3CB/INPPL1/PIK3R1/GPAA1/IMPA2 8 GO:0017157 regulation of exocytosis 10/852 202/18722 0.438631560000939 0.657794367112586 SYT8/SDC4/GATA2/STXBP5/RAB8B/SDC1/LAMP1/AP1G1/FMR1/ATP6AP1 10 GO:0017148 negative regulation of translation 12/852 245/18722 0.439049191138757 0.657794367112586 MEX3D/IGF2BP2/EIF4EBP1/CALR/EIF4EBP2/PABPC1/DAPK1/ZFP36L1/RNF139/FMR1/ATF4/IGF2BP3 12 GO:0097696 receptor signaling pathway via STAT 9/852 181/18722 0.441372096149097 0.657794367112586 IL6ST/MGAT5/CSH1/TGFB1/PTK2B/CSF1R/STAT2/JAK1/IFNAR1 9 GO:0051090 regulation of DNA-binding transcription factor activity 21/852 440/18722 0.443000515365653 0.657794367112586 IL1RAP/TCF7L2/SMAD3/ID3/FLNA/PLPP3/TNFAIP3/WFS1/ARHGEF2/MTDH/ANXA4/DAP/CTNNB1/HDAC5/PINK1/NLRP2/MAPK3/PPP3CA/JUP/ID1/SRI 21 GO:0006475 internal protein amino acid acetylation 8/852 160/18722 0.444228515528775 0.657794367112586 GATA3/GATA2/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 8 GO:0043271 negative regulation of ion transport 8/852 160/18722 0.444228515528775 0.657794367112586 SERPINE2/RRAD/PTK2B/EPHB2/SESTD1/TMBIM6/FMR1/SRI 8 GO:0035282 segmentation 5/852 96/18722 0.444619928866931 0.657794367112586 SFRP1/SMAD3/PCSK6/TMED2/TP53 5 GO:0042472 inner ear morphogenesis 5/852 96/18722 0.444619928866931 0.657794367112586 GATA3/GATA2/EPHB2/INSIG1/MYO6 5 GO:0055017 cardiac muscle tissue growth 5/852 96/18722 0.444619928866931 0.657794367112586 NOG/CITED2/PDLIM5/TGFB2/TGFBR3 5 GO:0006094 gluconeogenesis 4/852 75/18722 0.446756596764751 0.657794367112586 FAM3C/ATF3/DDB1/ATF4 4 GO:0006505 GPI anchor metabolic process 2/852 33/18722 0.446804303378804 0.657794367112586 PIGT/GPAA1 2 GO:0006654 phosphatidic acid biosynthetic process 2/852 33/18722 0.446804303378804 0.657794367112586 LPCAT1/DGKZ 2 GO:0009156 ribonucleoside monophosphate biosynthetic process 2/852 33/18722 0.446804303378804 0.657794367112586 RFK/CMPK1 2 GO:0009648 photoperiodism 2/852 33/18722 0.446804303378804 0.657794367112586 PPP1CB/TP53 2 GO:0010737 protein kinase A signaling 2/852 33/18722 0.446804303378804 0.657794367112586 MIF/EZR 2 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 2/852 33/18722 0.446804303378804 0.657794367112586 ITGA5/EPN2 2 GO:0033198 response to ATP 2/852 33/18722 0.446804303378804 0.657794367112586 HSP90B1/P2RX4 2 GO:0036336 dendritic cell migration 2/852 33/18722 0.446804303378804 0.657794367112586 CCR1/CALR 2 GO:0045648 positive regulation of erythrocyte differentiation 2/852 33/18722 0.446804303378804 0.657794367112586 GATA2/ISG15 2 GO:0046320 regulation of fatty acid oxidation 2/852 33/18722 0.446804303378804 0.657794367112586 PRKAG2/MFSD2A 2 GO:0046685 response to arsenic-containing substance 2/852 33/18722 0.446804303378804 0.657794367112586 ATF3/ATF4 2 GO:0061842 microtubule organizing center localization 2/852 33/18722 0.446804303378804 0.657794367112586 SUN2/EZR 2 GO:0071295 cellular response to vitamin 2/852 33/18722 0.446804303378804 0.657794367112586 SFRP1/PTN 2 GO:0071353 cellular response to interleukin-4 2/852 33/18722 0.446804303378804 0.657794367112586 GATA3/XBP1 2 GO:0071763 nuclear membrane organization 2/852 33/18722 0.446804303378804 0.657794367112586 REEP3/CTDNEP1 2 GO:0099084 postsynaptic specialization organization 2/852 33/18722 0.446804303378804 0.657794367112586 IL1RAP/PTPRS 2 GO:0099174 regulation of presynapse organization 2/852 33/18722 0.446804303378804 0.657794367112586 IL1RAP/GPC4 2 GO:0110110 positive regulation of animal organ morphogenesis 2/852 33/18722 0.446804303378804 0.657794367112586 GATA3/CTNNB1 2 GO:1900181 negative regulation of protein localization to nucleus 2/852 33/18722 0.446804303378804 0.657794367112586 PKIG/MAGED1 2 GO:1905606 regulation of presynapse assembly 2/852 33/18722 0.446804303378804 0.657794367112586 IL1RAP/GPC4 2 GO:2000036 regulation of stem cell population maintenance 2/852 33/18722 0.446804303378804 0.657794367112586 PTN/TAF5L 2 GO:0018205 peptidyl-lysine modification 18/852 376/18722 0.446959806754039 0.657794367112586 FKBP10/GATA3/PLOD3/PLOD2/PLOD1/GATA2/SOX4/P3H4/SMYD3/TET3/MORF4L2/TAF5L/CTNNB1/NCOA1/EGR1/JADE1/MAPK3/MBD3 18 GO:0008037 cell recognition 11/852 225/18722 0.447699685517657 0.657794367112586 CD9/SEMA5A/EPHB2/SCARB1/B4GALT1/PALLD/LY6K/RTN4/LGALS3/BSG/NPTN 11 GO:0009260 ribonucleotide biosynthetic process 9/852 182/18722 0.447878346845278 0.657794367112586 PRKAG2/TGFB1/TECR/ADCY7/PINK1/ACSL4/RFK/CMPK1/ACSL3 9 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 3/852 54/18722 0.448123980698666 0.657794367112586 ACVRL1/SEMA5A/GATA2 3 GO:0010659 cardiac muscle cell apoptotic process 3/852 54/18722 0.448123980698666 0.657794367112586 CAPN2/TP53/MDK 3 GO:0030520 intracellular estrogen receptor signaling pathway 3/852 54/18722 0.448123980698666 0.657794367112586 CARM1/RBFOX2/DDX17 3 GO:0035065 regulation of histone acetylation 3/852 54/18722 0.448123980698666 0.657794367112586 GATA3/GATA2/MAPK3 3 GO:0043647 inositol phosphate metabolic process 3/852 54/18722 0.448123980698666 0.657794367112586 PTK2B/IPMK/IMPA2 3 GO:0070228 regulation of lymphocyte apoptotic process 3/852 54/18722 0.448123980698666 0.657794367112586 EFNA1/LGALS3/TP53 3 GO:0051101 regulation of DNA binding 6/852 118/18722 0.45032848220248 0.657794367112586 GATA3/TGFB1/CTNNB1/TXN/ID1/SRI 6 GO:0071346 cellular response to interferon-gamma 6/852 118/18722 0.45032848220248 0.657794367112586 FLNB/IFNGR2/DAPK1/JAK1/TP53/MYO1C 6 GO:0019932 second-messenger-mediated signaling 15/852 312/18722 0.451204195735536 0.657794367112586 ADM/POMC/PTK2B/APOE/CCR1/EDNRB/EIF4EBP2/FHL2/RCAN1/ACKR2/PPP3CA/ITPR2/P2RX4/CAMTA1/NFAT5 15 GO:0002703 regulation of leukocyte mediated immunity 11/852 226/18722 0.453542692850297 0.657794367112586 HLA-G/IL1R1/GATA3/DNASE1L3/GATA2/TGFB1/PVR/LAMP1/BST2/AP1G1/NDFIP1 11 GO:0006721 terpenoid metabolic process 5/852 97/18722 0.45357486342217 0.657794367112586 TTR/CRABP2/DHRS3/LRP1/RDH10 5 GO:0010596 negative regulation of endothelial cell migration 5/852 97/18722 0.45357486342217 0.657794367112586 ACVRL1/TGFB1/APOE/HDAC5/JUP 5 GO:0120162 positive regulation of cold-induced thermogenesis 5/852 97/18722 0.45357486342217 0.657794367112586 DIO2/EPAS1/PLAC8/MFAP2/FABP5 5 GO:0002087 regulation of respiratory gaseous exchange by nervous system process 1/852 13/18722 0.454300262285585 0.657794367112586 GLS 1 GO:0002551 mast cell chemotaxis 1/852 13/18722 0.454300262285585 0.657794367112586 PGF 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/852 13/18722 0.454300262285585 0.657794367112586 CTNNB1 1 GO:0007494 midgut development 1/852 13/18722 0.454300262285585 0.657794367112586 EDNRB 1 GO:0007567 parturition 1/852 13/18722 0.454300262285585 0.657794367112586 HPGD 1 GO:0010635 regulation of mitochondrial fusion 1/852 13/18722 0.454300262285585 0.657794367112586 VAT1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 ABCA1 1 GO:0010958 regulation of amino acid import across plasma membrane 1/852 13/18722 0.454300262285585 0.657794367112586 ITGB1 1 GO:0014029 neural crest formation 1/852 13/18722 0.454300262285585 0.657794367112586 SFRP1 1 GO:0015801 aromatic amino acid transport 1/852 13/18722 0.454300262285585 0.657794367112586 SLC7A1 1 GO:0015809 arginine transport 1/852 13/18722 0.454300262285585 0.657794367112586 SLC7A1 1 GO:0016322 neuron remodeling 1/852 13/18722 0.454300262285585 0.657794367112586 NTN4 1 GO:0021514 ventral spinal cord interneuron differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 GATA2 1 GO:0021794 thalamus development 1/852 13/18722 0.454300262285585 0.657794367112586 PTN 1 GO:0021819 layer formation in cerebral cortex 1/852 13/18722 0.454300262285585 0.657794367112586 CTNNB1 1 GO:0021859 pyramidal neuron differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 GBA 1 GO:0030497 fatty acid elongation 1/852 13/18722 0.454300262285585 0.657794367112586 TECR 1 GO:0031053 primary miRNA processing 1/852 13/18722 0.454300262285585 0.657794367112586 SMAD3 1 GO:0031282 regulation of guanylate cyclase activity 1/852 13/18722 0.454300262285585 0.657794367112586 GUCA2A 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 FABP5 1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 1/852 13/18722 0.454300262285585 0.657794367112586 TNFAIP3 1 GO:0032042 mitochondrial DNA metabolic process 1/852 13/18722 0.454300262285585 0.657794367112586 TP53 1 GO:0032252 secretory granule localization 1/852 13/18722 0.454300262285585 0.657794367112586 USO1 1 GO:0032429 regulation of phospholipase A2 activity 1/852 13/18722 0.454300262285585 0.657794367112586 LRP1 1 GO:0032905 transforming growth factor beta1 production 1/852 13/18722 0.454300262285585 0.657794367112586 FURIN 1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 1/852 13/18722 0.454300262285585 0.657794367112586 CTNNB1 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/852 13/18722 0.454300262285585 0.657794367112586 TNFAIP3 1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 1/852 13/18722 0.454300262285585 0.657794367112586 TNFAIP3 1 GO:0034309 primary alcohol biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 H6PD 1 GO:0034497 protein localization to phagophore assembly site 1/852 13/18722 0.454300262285585 0.657794367112586 WIPI1 1 GO:0035331 negative regulation of hippo signaling 1/852 13/18722 0.454300262285585 0.657794367112586 WWC3 1 GO:0035745 T-helper 2 cell cytokine production 1/852 13/18722 0.454300262285585 0.657794367112586 GATA3 1 GO:0035845 photoreceptor cell outer segment organization 1/852 13/18722 0.454300262285585 0.657794367112586 MFSD2A 1 GO:0036005 response to macrophage colony-stimulating factor 1/852 13/18722 0.454300262285585 0.657794367112586 CSF1R 1 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 1/852 13/18722 0.454300262285585 0.657794367112586 CSF1R 1 GO:0036302 atrioventricular canal development 1/852 13/18722 0.454300262285585 0.657794367112586 ENG 1 GO:0042308 negative regulation of protein import into nucleus 1/852 13/18722 0.454300262285585 0.657794367112586 PKIG 1 GO:0042492 gamma-delta T cell differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 SOX4 1 GO:0042538 hyperosmotic salinity response 1/852 13/18722 0.454300262285585 0.657794367112586 EFHD1 1 GO:0042541 hemoglobin biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 INHA 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 TECR 1 GO:0042769 DNA damage response, detection of DNA damage 1/852 13/18722 0.454300262285585 0.657794367112586 SOX4 1 GO:0043970 histone H3-K9 acetylation 1/852 13/18722 0.454300262285585 0.657794367112586 GATA3 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/852 13/18722 0.454300262285585 0.657794367112586 ADAM17 1 GO:0046512 sphingosine biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 GBA 1 GO:0046520 sphingoid biosynthetic process 1/852 13/18722 0.454300262285585 0.657794367112586 GBA 1 GO:0046642 negative regulation of alpha-beta T cell proliferation 1/852 13/18722 0.454300262285585 0.657794367112586 CBLB 1 GO:0046689 response to mercury ion 1/852 13/18722 0.454300262285585 0.657794367112586 BSG 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/852 13/18722 0.454300262285585 0.657794367112586 NDFIP1 1 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 1/852 13/18722 0.454300262285585 0.657794367112586 SRI 1 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/852 13/18722 0.454300262285585 0.657794367112586 PABPC1 1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/852 13/18722 0.454300262285585 0.657794367112586 UBE2K 1 GO:0070234 positive regulation of T cell apoptotic process 1/852 13/18722 0.454300262285585 0.657794367112586 TP53 1 GO:0070316 regulation of G0 to G1 transition 1/852 13/18722 0.454300262285585 0.657794367112586 HLA-G 1 GO:0070486 leukocyte aggregation 1/852 13/18722 0.454300262285585 0.657794367112586 JAM2 1 GO:0070914 UV-damage excision repair 1/852 13/18722 0.454300262285585 0.657794367112586 DDB1 1 GO:0071696 ectodermal placode development 1/852 13/18722 0.454300262285585 0.657794367112586 CTNNB1 1 GO:0071801 regulation of podosome assembly 1/852 13/18722 0.454300262285585 0.657794367112586 GSN 1 GO:0072578 neurotransmitter-gated ion channel clustering 1/852 13/18722 0.454300262285585 0.657794367112586 APOE 1 GO:0090042 tubulin deacetylation 1/852 13/18722 0.454300262285585 0.657794367112586 FLNA 1 GO:0090161 Golgi ribbon formation 1/852 13/18722 0.454300262285585 0.657794367112586 GOLPH3 1 GO:0097154 GABAergic neuron differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 GATA2 1 GO:0098814 spontaneous synaptic transmission 1/852 13/18722 0.454300262285585 0.657794367112586 ITGB1 1 GO:0098840 protein transport along microtubule 1/852 13/18722 0.454300262285585 0.657794367112586 HSPB1 1 GO:0099118 microtubule-based protein transport 1/852 13/18722 0.454300262285585 0.657794367112586 HSPB1 1 GO:1900044 regulation of protein K63-linked ubiquitination 1/852 13/18722 0.454300262285585 0.657794367112586 SASH1 1 GO:1900452 regulation of long-term synaptic depression 1/852 13/18722 0.454300262285585 0.657794367112586 FMR1 1 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 1/852 13/18722 0.454300262285585 0.657794367112586 PLXNB2 1 GO:1902947 regulation of tau-protein kinase activity 1/852 13/18722 0.454300262285585 0.657794367112586 EGR1 1 GO:1903651 positive regulation of cytoplasmic transport 1/852 13/18722 0.454300262285585 0.657794367112586 EZR 1 GO:1903789 regulation of amino acid transmembrane transport 1/852 13/18722 0.454300262285585 0.657794367112586 ITGB1 1 GO:1904590 negative regulation of protein import 1/852 13/18722 0.454300262285585 0.657794367112586 PKIG 1 GO:1905203 regulation of connective tissue replacement 1/852 13/18722 0.454300262285585 0.657794367112586 PPP3CA 1 GO:1905244 regulation of modification of synaptic structure 1/852 13/18722 0.454300262285585 0.657794367112586 TIAM1 1 GO:1905939 regulation of gonad development 1/852 13/18722 0.454300262285585 0.657794367112586 CITED2 1 GO:1990403 embryonic brain development 1/852 13/18722 0.454300262285585 0.657794367112586 CTNNB1 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/852 13/18722 0.454300262285585 0.657794367112586 GATA3 1 GO:2001023 regulation of response to drug 1/852 13/18722 0.454300262285585 0.657794367112586 NCOA1 1 GO:2001198 regulation of dendritic cell differentiation 1/852 13/18722 0.454300262285585 0.657794367112586 HLA-G 1 GO:0006305 DNA alkylation 4/852 76/18722 0.456904046481409 0.660234873942272 TET3/GRHL2/MBD2/MBD3 4 GO:0006306 DNA methylation 4/852 76/18722 0.456904046481409 0.660234873942272 TET3/GRHL2/MBD2/MBD3 4 GO:0014855 striated muscle cell proliferation 4/852 76/18722 0.456904046481409 0.660234873942272 NOG/CITED2/TGFB2/TGFBR3 4 GO:0032720 negative regulation of tumor necrosis factor production 4/852 76/18722 0.456904046481409 0.660234873942272 TSPO/POMC/TNFAIP3/ERRFI1 4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 4/852 76/18722 0.456904046481409 0.660234873942272 RPS27L/MIF/TP53/SHISA5 4 GO:0140029 exocytic process 4/852 76/18722 0.456904046481409 0.660234873942272 STXBP5/RAB8B/SNAP23/CTBP2 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/852 76/18722 0.456904046481409 0.660234873942272 TSPO/TGFB1/PTK2B/TP53 4 GO:0031398 positive regulation of protein ubiquitination 6/852 119/18722 0.458404140946424 0.662212411418873 WFS1/CBLB/PINK1/NDFIP2/XIAP/NDFIP1 6 GO:0006360 transcription by RNA polymerase I 3/852 55/18722 0.460112221652551 0.663917663869636 ERBB2/FLNA/ATF4 3 GO:0006414 translational elongation 3/852 55/18722 0.460112221652551 0.663917663869636 DIO2/LTN1/ASCC2 3 GO:0010676 positive regulation of cellular carbohydrate metabolic process 3/852 55/18722 0.460112221652551 0.663917663869636 IGF2/INSR/DDB1 3 GO:0046164 alcohol catabolic process 3/852 55/18722 0.460112221652551 0.663917663869636 APOE/SCARB1/IMPA2 3 GO:1903038 negative regulation of leukocyte cell-cell adhesion 7/852 141/18722 0.462060607306538 0.664476862205229 HLA-G/SDC4/ERBB2/CBLB/LGALS3/NDFIP1/MDK 7 GO:0000038 very long-chain fatty acid metabolic process 2/852 34/18722 0.462216072835388 0.664476862205229 TECR/ACOX1 2 GO:0002446 neutrophil mediated immunity 2/852 34/18722 0.462216072835388 0.664476862205229 DNASE1L3/ADAM17 2 GO:0007616 long-term memory 2/852 34/18722 0.462216072835388 0.664476862205229 APOE/LDLR 2 GO:0009112 nucleobase metabolic process 2/852 34/18722 0.462216072835388 0.664476862205229 TTR/CMPK1 2 GO:0009303 rRNA transcription 2/852 34/18722 0.462216072835388 0.664476862205229 SPIN1/TP53 2 GO:0010661 positive regulation of muscle cell apoptotic process 2/852 34/18722 0.462216072835388 0.664476862205229 CAPN2/TP53 2 GO:0014072 response to isoquinoline alkaloid 2/852 34/18722 0.462216072835388 0.664476862205229 PEA15/FOSB 2 GO:0030851 granulocyte differentiation 2/852 34/18722 0.462216072835388 0.664476862205229 CITED2/GATA2 2 GO:0035308 negative regulation of protein dephosphorylation 2/852 34/18722 0.462216072835388 0.664476862205229 MGAT5/LGALS3 2 GO:0042573 retinoic acid metabolic process 2/852 34/18722 0.462216072835388 0.664476862205229 CRABP2/RDH10 2 GO:0043278 response to morphine 2/852 34/18722 0.462216072835388 0.664476862205229 PEA15/FOSB 2 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 2/852 34/18722 0.462216072835388 0.664476862205229 MIF/TP53 2 GO:0032642 regulation of chemokine production 5/852 98/18722 0.462490201618165 0.664681092159972 LPL/CSF1R/EGR1/LRP1/ADAM17 5 GO:0007052 mitotic spindle organization 6/852 120/18722 0.466450634676274 0.668765386850251 FLNA/PLK2/SUN2/CCSAP/TACC1/MAP4 6 GO:0140056 organelle localization by membrane tethering 4/852 77/18722 0.466988054042866 0.668765386850251 RAB8B/CTBP2/CAV2/USO1 4 GO:1901983 regulation of protein acetylation 4/852 77/18722 0.466988054042866 0.668765386850251 GATA3/GATA2/SOX4/MAPK3 4 GO:0050729 positive regulation of inflammatory response 7/852 142/18722 0.469452373233153 0.668765386850251 SERPINE1/IL6ST/PLA2G7/LPL/GRN/LDLR/MDK 7 GO:0002444 myeloid leukocyte mediated immunity 5/852 99/18722 0.471362202043605 0.668765386850251 DNASE1L3/GATA2/SNAP23/S100A13/ADAM17 5 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 5/852 99/18722 0.471362202043605 0.668765386850251 RPS27L/MIF/TP53/SHISA5/PIK3R1 5 GO:0021510 spinal cord development 5/852 99/18722 0.471362202043605 0.668765386850251 NOG/PTN/GATA2/PTPRS/SOX4 5 GO:0032602 chemokine production 5/852 99/18722 0.471362202043605 0.668765386850251 LPL/CSF1R/EGR1/LRP1/ADAM17 5 GO:0042100 B cell proliferation 5/852 99/18722 0.471362202043605 0.668765386850251 PLCL2/EPHB2/PKN1/CD320/MIF 5 GO:0050792 regulation of viral process 8/852 164/18722 0.47183305797405 0.668765386850251 P4HB/ISG15/PABPC1/BST2/CAV2/DDB1/GSN/FMR1 8 GO:0010332 response to gamma radiation 3/852 56/18722 0.471987032768523 0.668765386850251 GATA3/EGR1/TP53 3 GO:0010658 striated muscle cell apoptotic process 3/852 56/18722 0.471987032768523 0.668765386850251 CAPN2/TP53/MDK 3 GO:0046456 icosanoid biosynthetic process 3/852 56/18722 0.471987032768523 0.668765386850251 PTGES/FABP5/MIF 3 GO:0051653 spindle localization 3/852 56/18722 0.471987032768523 0.668765386850251 ITGB1/MYH9/MAP4 3 GO:0055078 sodium ion homeostasis 3/852 56/18722 0.471987032768523 0.668765386850251 EDNRB/SLC1A3/EXT2 3 GO:0090175 regulation of establishment of planar polarity 3/852 56/18722 0.471987032768523 0.668765386850251 SFRP1/GPC4/TIAM1 3 GO:0098781 ncRNA transcription 3/852 56/18722 0.471987032768523 0.668765386850251 ELL2/SPIN1/TP53 3 GO:0034763 negative regulation of transmembrane transport 7/852 143/18722 0.476819245247894 0.668765386850251 RRAD/EPHB2/SESTD1/PEA15/FABP5/FMR1/SRI 7 GO:0062013 positive regulation of small molecule metabolic process 7/852 143/18722 0.476819245247894 0.668765386850251 IGF2/ADM/GUCA2A/INSR/PINK1/RDH10/DDB1 7 GO:0008306 associative learning 4/852 78/18722 0.477003645033848 0.668765386850251 ITGB1/ABCA7/TPBG/NPTN 4 GO:0009064 glutamine family amino acid metabolic process 4/852 78/18722 0.477003645033848 0.668765386850251 PYCR1/SLC39A8/GFPT1/GLS 4 GO:0019319 hexose biosynthetic process 4/852 78/18722 0.477003645033848 0.668765386850251 FAM3C/ATF3/DDB1/ATF4 4 GO:0090559 regulation of membrane permeability 4/852 78/18722 0.477003645033848 0.668765386850251 F11R/TMEM14A/TP53/TJP2 4 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 4/852 78/18722 0.477003645033848 0.668765386850251 TSPO/POMC/TNFAIP3/ERRFI1 4 GO:0006471 protein ADP-ribosylation 2/852 35/18722 0.477372638839926 0.668765386850251 TNKS2/ARF4 2 GO:0006739 NADP metabolic process 2/852 35/18722 0.477372638839926 0.668765386850251 H6PD/TP53 2 GO:0031076 embryonic camera-type eye development 2/852 35/18722 0.477372638839926 0.668765386850251 CITED2/RDH10 2 GO:0032814 regulation of natural killer cell activation 2/852 35/18722 0.477372638839926 0.668765386850251 LAMP1/AP1G1 2 GO:0033280 response to vitamin D 2/852 35/18722 0.477372638839926 0.668765386850251 SFRP1/PTN 2 GO:0039694 viral RNA genome replication 2/852 35/18722 0.477372638839926 0.668765386850251 FMR1/PCBP2 2 GO:0042462 eye photoreceptor cell development 2/852 35/18722 0.477372638839926 0.668765386850251 NAGLU/TUG1 2 GO:0044273 sulfur compound catabolic process 2/852 35/18722 0.477372638839926 0.668765386850251 GNS/GLB1 2 GO:0046640 regulation of alpha-beta T cell proliferation 2/852 35/18722 0.477372638839926 0.668765386850251 EBI3/CBLB 2 GO:0048821 erythrocyte development 2/852 35/18722 0.477372638839926 0.668765386850251 CITED2/PTBP3 2 GO:0070536 protein K63-linked deubiquitination 2/852 35/18722 0.477372638839926 0.668765386850251 TNFAIP3/OTUD1 2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2/852 35/18722 0.477372638839926 0.668765386850251 GATA2/PLK2 2 GO:0090181 regulation of cholesterol metabolic process 2/852 35/18722 0.477372638839926 0.668765386850251 APOE/LDLR 2 GO:0098801 regulation of renal system process 2/852 35/18722 0.477372638839926 0.668765386850251 EDNRB/GJA5 2 GO:0098810 neurotransmitter reuptake 2/852 35/18722 0.477372638839926 0.668765386850251 ITGB1/SLC6A2 2 GO:1905207 regulation of cardiocyte differentiation 2/852 35/18722 0.477372638839926 0.668765386850251 TGFB1/TGFB2 2 GO:0000212 meiotic spindle organization 1/852 14/18722 0.479151199082457 0.668765386850251 MYH9 1 GO:0001711 endodermal cell fate commitment 1/852 14/18722 0.479151199082457 0.668765386850251 CTNNB1 1 GO:0001771 immunological synapse formation 1/852 14/18722 0.479151199082457 0.668765386850251 LGALS3 1 GO:0002091 negative regulation of receptor internalization 1/852 14/18722 0.479151199082457 0.668765386850251 ANKRD13A 1 GO:0002475 antigen processing and presentation via MHC class Ib 1/852 14/18722 0.479151199082457 0.668765386850251 HLA-G 1 GO:0002829 negative regulation of type 2 immune response 1/852 14/18722 0.479151199082457 0.668765386850251 NDFIP1 1 GO:0006999 nuclear pore organization 1/852 14/18722 0.479151199082457 0.668765386850251 RTN4 1 GO:0007638 mechanosensory behavior 1/852 14/18722 0.479151199082457 0.668765386850251 SLC1A3 1 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 1/852 14/18722 0.479151199082457 0.668765386850251 CMPK1 1 GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 1/852 14/18722 0.479151199082457 0.668765386850251 CMPK1 1 GO:0010457 centriole-centriole cohesion 1/852 14/18722 0.479151199082457 0.668765386850251 CTNNB1 1 GO:0019321 pentose metabolic process 1/852 14/18722 0.479151199082457 0.668765386850251 UXS1 1 GO:0030007 cellular potassium ion homeostasis 1/852 14/18722 0.479151199082457 0.668765386850251 KCNJ2 1 GO:0030049 muscle filament sliding 1/852 14/18722 0.479151199082457 0.668765386850251 TPM1 1 GO:0030213 hyaluronan biosynthetic process 1/852 14/18722 0.479151199082457 0.668765386850251 TGFB1 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/852 14/18722 0.479151199082457 0.668765386850251 EPN2 1 GO:0031115 negative regulation of microtubule polymerization 1/852 14/18722 0.479151199082457 0.668765386850251 ARHGEF7 1 GO:0031468 nuclear membrane reassembly 1/852 14/18722 0.479151199082457 0.668765386850251 REEP3 1 GO:0032688 negative regulation of interferon-beta production 1/852 14/18722 0.479151199082457 0.668765386850251 PTPRS 1 GO:0032966 negative regulation of collagen biosynthetic process 1/852 14/18722 0.479151199082457 0.668765386850251 ERRFI1 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/852 14/18722 0.479151199082457 0.668765386850251 GATA2 1 GO:0033212 iron import into cell 1/852 14/18722 0.479151199082457 0.668765386850251 SLC39A8 1 GO:0033605 positive regulation of catecholamine secretion 1/852 14/18722 0.479151199082457 0.668765386850251 PINK1 1 GO:0035672 oligopeptide transmembrane transport 1/852 14/18722 0.479151199082457 0.668765386850251 SLC15A3 1 GO:0035810 positive regulation of urine volume 1/852 14/18722 0.479151199082457 0.668765386850251 EDNRB 1 GO:0035815 positive regulation of renal sodium excretion 1/852 14/18722 0.479151199082457 0.668765386850251 EDNRB 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/852 14/18722 0.479151199082457 0.668765386850251 LPCAT1 1 GO:0036295 cellular response to increased oxygen levels 1/852 14/18722 0.479151199082457 0.668765386850251 ATP6AP1 1 GO:0042921 glucocorticoid receptor signaling pathway 1/852 14/18722 0.479151199082457 0.668765386850251 CALR 1 GO:0043249 erythrocyte maturation 1/852 14/18722 0.479151199082457 0.668765386850251 PTBP3 1 GO:0043306 positive regulation of mast cell degranulation 1/852 14/18722 0.479151199082457 0.668765386850251 GATA2 1 GO:0043650 dicarboxylic acid biosynthetic process 1/852 14/18722 0.479151199082457 0.668765386850251 GLS 1 GO:0044154 histone H3-K14 acetylation 1/852 14/18722 0.479151199082457 0.668765386850251 GATA3 1 GO:0045023 G0 to G1 transition 1/852 14/18722 0.479151199082457 0.668765386850251 HLA-G 1 GO:0045472 response to ether 1/852 14/18722 0.479151199082457 0.668765386850251 GOLPH3 1 GO:0045837 negative regulation of membrane potential 1/852 14/18722 0.479151199082457 0.668765386850251 PTN 1 GO:0046049 UMP metabolic process 1/852 14/18722 0.479151199082457 0.668765386850251 CMPK1 1 GO:0046325 negative regulation of glucose import 1/852 14/18722 0.479151199082457 0.668765386850251 PEA15 1 GO:0046348 amino sugar catabolic process 1/852 14/18722 0.479151199082457 0.668765386850251 MGAT1 1 GO:0046462 monoacylglycerol metabolic process 1/852 14/18722 0.479151199082457 0.668765386850251 MGLL 1 GO:0048291 isotype switching to IgG isotypes 1/852 14/18722 0.479151199082457 0.668765386850251 NDFIP1 1 GO:0048368 lateral mesoderm development 1/852 14/18722 0.479151199082457 0.668765386850251 CITED2 1 GO:0048681 negative regulation of axon regeneration 1/852 14/18722 0.479151199082457 0.668765386850251 PTPRS 1 GO:0050872 white fat cell differentiation 1/852 14/18722 0.479151199082457 0.668765386850251 CTBP2 1 GO:0050930 induction of positive chemotaxis 1/852 14/18722 0.479151199082457 0.668765386850251 PGF 1 GO:0051589 negative regulation of neurotransmitter transport 1/852 14/18722 0.479151199082457 0.668765386850251 FMR1 1 GO:0051917 regulation of fibrinolysis 1/852 14/18722 0.479151199082457 0.668765386850251 SERPINE1 1 GO:0055057 neuroblast division 1/852 14/18722 0.479151199082457 0.668765386850251 ARHGEF2 1 GO:0070278 extracellular matrix constituent secretion 1/852 14/18722 0.479151199082457 0.668765386850251 ENG 1 GO:0070307 lens fiber cell development 1/852 14/18722 0.479151199082457 0.668765386850251 ATF4 1 GO:0070942 neutrophil mediated cytotoxicity 1/852 14/18722 0.479151199082457 0.668765386850251 DNASE1L3 1 GO:0071236 cellular response to antibiotic 1/852 14/18722 0.479151199082457 0.668765386850251 TP53 1 GO:0072176 nephric duct development 1/852 14/18722 0.479151199082457 0.668765386850251 GATA3 1 GO:0097091 synaptic vesicle clustering 1/852 14/18722 0.479151199082457 0.668765386850251 CTNNB1 1 GO:0097531 mast cell migration 1/852 14/18722 0.479151199082457 0.668765386850251 PGF 1 GO:0098734 macromolecule depalmitoylation 1/852 14/18722 0.479151199082457 0.668765386850251 LYPLA1 1 GO:0099188 postsynaptic cytoskeleton organization 1/852 14/18722 0.479151199082457 0.668765386850251 ACTB 1 GO:1901077 regulation of relaxation of muscle 1/852 14/18722 0.479151199082457 0.668765386850251 SRI 1 GO:1901678 iron coordination entity transport 1/852 14/18722 0.479151199082457 0.668765386850251 PGRMC2 1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/852 14/18722 0.479151199082457 0.668765386850251 MIF 1 GO:1902916 positive regulation of protein polyubiquitination 1/852 14/18722 0.479151199082457 0.668765386850251 XIAP 1 GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/852 14/18722 0.479151199082457 0.668765386850251 OS9 1 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 1/852 14/18722 0.479151199082457 0.668765386850251 ENG 1 GO:2001171 positive regulation of ATP biosynthetic process 1/852 14/18722 0.479151199082457 0.668765386850251 PINK1 1 GO:0006626 protein targeting to mitochondrion 5/852 100/18722 0.480187259500399 0.669839932667823 TSPO/RHOU/LMAN1/PINK1/SH3GLB1 5 GO:0044728 DNA methylation or demethylation 5/852 100/18722 0.480187259500399 0.669839932667823 GATA3/TET3/GRHL2/MBD2/MBD3 5 GO:0051928 positive regulation of calcium ion transport 6/852 122/18722 0.482444833247575 0.672802672689123 TSPO/CCR1/WFS1/LGALS3/P2RX4/SRI 6 GO:0006695 cholesterol biosynthetic process 3/852 57/18722 0.483741536441851 0.673118925328127 APOE/INSIG1/CYB5R3 3 GO:0006754 ATP biosynthetic process 3/852 57/18722 0.483741536441851 0.673118925328127 PRKAG2/TGFB1/PINK1 3 GO:0010883 regulation of lipid storage 3/852 57/18722 0.483741536441851 0.673118925328127 LPL/SCARB1/ABCA1 3 GO:0050879 multicellular organismal movement 3/852 57/18722 0.483741536441851 0.673118925328127 KCNJ2/GAA/C12orf57 3 GO:0050881 musculoskeletal movement 3/852 57/18722 0.483741536441851 0.673118925328127 KCNJ2/GAA/C12orf57 3 GO:0051205 protein insertion into membrane 3/852 57/18722 0.483741536441851 0.673118925328127 TRAM2/TRAM1/EMC10 3 GO:0060760 positive regulation of response to cytokine stimulus 3/852 57/18722 0.483741536441851 0.673118925328127 IL1R1/UBE2K/ADAM17 3 GO:1902653 secondary alcohol biosynthetic process 3/852 57/18722 0.483741536441851 0.673118925328127 APOE/INSIG1/CYB5R3 3 GO:0006476 protein deacetylation 5/852 101/18722 0.488961905321119 0.68000698244852 FLNA/MORF4L2/HDAC5/PINK1/TP53 5 GO:0048024 regulation of mRNA splicing, via spliceosome 5/852 101/18722 0.488961905321119 0.68000698244852 MBNL2/RBFOX2/SRSF6/FMR1/DDX17 5 GO:0050852 T cell receptor signaling pathway 6/852 123/18722 0.490387102104162 0.681775242392383 GATA3/CD276/CBLB/DGKZ/LGALS3/EZR 6 GO:0002691 regulation of cellular extravasation 2/852 36/18722 0.492265295222317 0.681775242392383 IL1R1/MDK 2 GO:0014046 dopamine secretion 2/852 36/18722 0.492265295222317 0.681775242392383 SYT8/PINK1 2 GO:0014059 regulation of dopamine secretion 2/852 36/18722 0.492265295222317 0.681775242392383 SYT8/PINK1 2 GO:0042092 type 2 immune response 2/852 36/18722 0.492265295222317 0.681775242392383 GATA3/NDFIP1 2 GO:0042119 neutrophil activation 2/852 36/18722 0.492265295222317 0.681775242392383 DNASE1L3/GRN 2 GO:0045191 regulation of isotype switching 2/852 36/18722 0.492265295222317 0.681775242392383 TGFB1/NDFIP1 2 GO:0045746 negative regulation of Notch signaling pathway 2/852 36/18722 0.492265295222317 0.681775242392383 GATA2/MMP14 2 GO:0051385 response to mineralocorticoid 2/852 36/18722 0.492265295222317 0.681775242392383 HSD3B1/FOSB 2 GO:0070306 lens fiber cell differentiation 2/852 36/18722 0.492265295222317 0.681775242392383 SMAD3/ATF4 2 GO:0070670 response to interleukin-4 2/852 36/18722 0.492265295222317 0.681775242392383 GATA3/XBP1 2 GO:0086010 membrane depolarization during action potential 2/852 36/18722 0.492265295222317 0.681775242392383 KCNJ2/PTPN3 2 GO:0090313 regulation of protein targeting to membrane 2/852 36/18722 0.492265295222317 0.681775242392383 ERBB2/MYO1C 2 GO:0097009 energy homeostasis 2/852 36/18722 0.492265295222317 0.681775242392383 PRCP/MFSD2A 2 GO:1901658 glycosyl compound catabolic process 2/852 36/18722 0.492265295222317 0.681775242392383 GBA/FUCA2 2 GO:0009161 ribonucleoside monophosphate metabolic process 3/852 58/18722 0.495369366395152 0.68256560917006 TJP2/RFK/CMPK1 3 GO:0010574 regulation of vascular endothelial growth factor production 3/852 58/18722 0.495369366395152 0.68256560917006 IL6ST/TGFB1/ATF4 3 GO:0042743 hydrogen peroxide metabolic process 3/852 58/18722 0.495369366395152 0.68256560917006 PRDX4/ACOX1/PINK1 3 GO:2000736 regulation of stem cell differentiation 3/852 58/18722 0.495369366395152 0.68256560917006 PTN/TGFB2/LTBP3 3 GO:0010522 regulation of calcium ion transport into cytosol 5/852 102/18722 0.497682807415676 0.68256560917006 PTK2B/UBASH3B/P2RX4/TMBIM6/SRI 5 GO:0045833 negative regulation of lipid metabolic process 5/852 102/18722 0.497682807415676 0.68256560917006 APOC1/LPCAT1/APOE/MFSD2A/INSIG1 5 GO:1904063 negative regulation of cation transmembrane transport 5/852 102/18722 0.497682807415676 0.68256560917006 RRAD/EPHB2/SESTD1/FMR1/SRI 5 GO:0007368 determination of left/right symmetry 6/852 124/18722 0.498289335401902 0.68256560917006 ENG/CITED2/SMAD3/PCSK6/NOTCH2/TMED2 6 GO:0045580 regulation of T cell differentiation 7/852 146/18722 0.49874878883649 0.68256560917006 HLA-G/GATA3/ERBB2/SOX4/XBP1/MDK/CLPTM1 7 GO:0002706 regulation of lymphocyte mediated immunity 8/852 168/18722 0.499117075166068 0.68256560917006 HLA-G/IL1R1/GATA3/TGFB1/PVR/LAMP1/AP1G1/NDFIP1 8 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/852 168/18722 0.499117075166068 0.68256560917006 HLA-G/IL1R1/GATA3/TGFB1/PVR/TNFAIP3/PKN1/NDFIP1 8 GO:0031349 positive regulation of defense response 13/852 278/18722 0.500314067170396 0.68256560917006 SERPINE1/IL6ST/HLA-G/PLA2G7/LPL/PVR/GRN/LAMP1/LDLR/MAPK3/AP1G1/MDK/UBE2K 13 GO:0002679 respiratory burst involved in defense response 1/852 15/18722 0.502871702523859 0.68256560917006 GRN 1 GO:0002730 regulation of dendritic cell cytokine production 1/852 15/18722 0.502871702523859 0.68256560917006 BST2 1 GO:0002836 positive regulation of response to tumor cell 1/852 15/18722 0.502871702523859 0.68256560917006 PVR 1 GO:0002839 positive regulation of immune response to tumor cell 1/852 15/18722 0.502871702523859 0.68256560917006 PVR 1 GO:0003356 regulation of cilium beat frequency 1/852 15/18722 0.502871702523859 0.68256560917006 CCSAP 1 GO:0006089 lactate metabolic process 1/852 15/18722 0.502871702523859 0.68256560917006 TP53 1 GO:0006684 sphingomyelin metabolic process 1/852 15/18722 0.502871702523859 0.68256560917006 SGMS2 1 GO:0006825 copper ion transport 1/852 15/18722 0.502871702523859 0.68256560917006 ATOX1 1 GO:0006878 cellular copper ion homeostasis 1/852 15/18722 0.502871702523859 0.68256560917006 ANKRD9 1 GO:0009163 nucleoside biosynthetic process 1/852 15/18722 0.502871702523859 0.68256560917006 AMD1 1 GO:0010273 detoxification of copper ion 1/852 15/18722 0.502871702523859 0.68256560917006 MT1X 1 GO:0010713 negative regulation of collagen metabolic process 1/852 15/18722 0.502871702523859 0.68256560917006 ERRFI1 1 GO:0010752 regulation of cGMP-mediated signaling 1/852 15/18722 0.502871702523859 0.68256560917006 PTK2B 1 GO:0010889 regulation of sequestering of triglyceride 1/852 15/18722 0.502871702523859 0.68256560917006 LPL 1 GO:0014733 regulation of skeletal muscle adaptation 1/852 15/18722 0.502871702523859 0.68256560917006 PPP3CA 1 GO:0014744 positive regulation of muscle adaptation 1/852 15/18722 0.502871702523859 0.68256560917006 PPP3CA 1 GO:0016114 terpenoid biosynthetic process 1/852 15/18722 0.502871702523859 0.68256560917006 RDH10 1 GO:0018216 peptidyl-arginine methylation 1/852 15/18722 0.502871702523859 0.68256560917006 CARM1 1 GO:0018298 protein-chromophore linkage 1/852 15/18722 0.502871702523859 0.68256560917006 OPN3 1 GO:0021542 dentate gyrus development 1/852 15/18722 0.502871702523859 0.68256560917006 MDK 1 GO:0031958 corticosteroid receptor signaling pathway 1/852 15/18722 0.502871702523859 0.68256560917006 CALR 1 GO:0033275 actin-myosin filament sliding 1/852 15/18722 0.502871702523859 0.68256560917006 TPM1 1 GO:0034404 nucleobase-containing small molecule biosynthetic process 1/852 15/18722 0.502871702523859 0.68256560917006 AMD1 1 GO:0042249 establishment of planar polarity of embryonic epithelium 1/852 15/18722 0.502871702523859 0.68256560917006 SFRP1 1 GO:0042976 activation of Janus kinase activity 1/852 15/18722 0.502871702523859 0.68256560917006 PTK2B 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/852 15/18722 0.502871702523859 0.68256560917006 SRI 1 GO:0043252 sodium-independent organic anion transport 1/852 15/18722 0.502871702523859 0.68256560917006 SLCO2A1 1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 1/852 15/18722 0.502871702523859 0.68256560917006 MIF 1 GO:0043584 nose development 1/852 15/18722 0.502871702523859 0.68256560917006 RDH10 1 GO:0043981 histone H4-K5 acetylation 1/852 15/18722 0.502871702523859 0.68256560917006 JADE1 1 GO:0043982 histone H4-K8 acetylation 1/852 15/18722 0.502871702523859 0.68256560917006 JADE1 1 GO:0044406 adhesion of symbiont to host 1/852 15/18722 0.502871702523859 0.68256560917006 SCARB1 1 GO:0045064 T-helper 2 cell differentiation 1/852 15/18722 0.502871702523859 0.68256560917006 GATA3 1 GO:0045217 cell-cell junction maintenance 1/852 15/18722 0.502871702523859 0.68256560917006 CSF1R 1 GO:0045346 regulation of MHC class II biosynthetic process 1/852 15/18722 0.502871702523859 0.68256560917006 XBP1 1 GO:0045986 negative regulation of smooth muscle contraction 1/852 15/18722 0.502871702523859 0.68256560917006 DOCK5 1 GO:0046834 lipid phosphorylation 1/852 15/18722 0.502871702523859 0.68256560917006 DGKZ 1 GO:0048308 organelle inheritance 1/852 15/18722 0.502871702523859 0.68256560917006 MAPK3 1 GO:0048313 Golgi inheritance 1/852 15/18722 0.502871702523859 0.68256560917006 MAPK3 1 GO:0048484 enteric nervous system development 1/852 15/18722 0.502871702523859 0.68256560917006 EDNRB 1 GO:0051284 positive regulation of sequestering of calcium ion 1/852 15/18722 0.502871702523859 0.68256560917006 SRI 1 GO:0051290 protein heterotetramerization 1/852 15/18722 0.502871702523859 0.68256560917006 KRT10 1 GO:0051608 histamine transport 1/852 15/18722 0.502871702523859 0.68256560917006 SNAP23 1 GO:0051775 response to redox state 1/852 15/18722 0.502871702523859 0.68256560917006 ARHGDIB 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/852 15/18722 0.502871702523859 0.68256560917006 FHL2 1 GO:0060026 convergent extension 1/852 15/18722 0.502871702523859 0.68256560917006 SFRP1 1 GO:0060046 regulation of acrosome reaction 1/852 15/18722 0.502871702523859 0.68256560917006 B4GALT1 1 GO:0060049 regulation of protein glycosylation 1/852 15/18722 0.502871702523859 0.68256560917006 TMEM59 1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/852 15/18722 0.502871702523859 0.68256560917006 PABPC1 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/852 15/18722 0.502871702523859 0.68256560917006 SAR1A 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/852 15/18722 0.502871702523859 0.68256560917006 CAMTA1 1 GO:0071380 cellular response to prostaglandin E stimulus 1/852 15/18722 0.502871702523859 0.68256560917006 SFRP1 1 GO:0071599 otic vesicle development 1/852 15/18722 0.502871702523859 0.68256560917006 GATA3 1 GO:0080154 regulation of fertilization 1/852 15/18722 0.502871702523859 0.68256560917006 MYH9 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/852 15/18722 0.502871702523859 0.68256560917006 PPP3CA 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/852 15/18722 0.502871702523859 0.68256560917006 CAMTA1 1 GO:1900029 positive regulation of ruffle assembly 1/852 15/18722 0.502871702523859 0.68256560917006 EPS8L2 1 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 1/852 15/18722 0.502871702523859 0.68256560917006 SESTD1 1 GO:1990169 stress response to copper ion 1/852 15/18722 0.502871702523859 0.68256560917006 MT1X 1 GO:1990822 basic amino acid transmembrane transport 1/852 15/18722 0.502871702523859 0.68256560917006 SLC7A1 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/852 15/18722 0.502871702523859 0.68256560917006 SFRP1 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/852 15/18722 0.502871702523859 0.68256560917006 FABP5 1 GO:0002699 positive regulation of immune effector process 11/852 235/18722 0.505653931166584 0.683407589449767 HLA-G/IL1R1/GATA3/GATA2/TGFB1/PVR/EPHB2/XBP1/LAMP1/SEMA7A/AP1G1 11 GO:0006164 purine nucleotide biosynthetic process 9/852 191/18722 0.505781534496882 0.683407589449767 PRKAG2/GUCA2A/TGFB1/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/ACSL3 9 GO:1902850 microtubule cytoskeleton organization involved in mitosis 7/852 147/18722 0.505994663489089 0.683407589449767 ITGB1/FLNA/PLK2/SUN2/CCSAP/TACC1/MAP4 7 GO:1903531 negative regulation of secretion by cell 7/852 147/18722 0.505994663489089 0.683407589449767 SFRP1/APOE/INHA/PPP3CA/FMR1/ERP29/FRMD4A 7 GO:0051053 negative regulation of DNA metabolic process 6/852 125/18722 0.506149029017726 0.683407589449767 GATA3/ACVRL1/TNKS2/BMPR2/TP53/NDFIP1 6 GO:0055007 cardiac muscle cell differentiation 6/852 125/18722 0.506149029017726 0.683407589449767 ITGB1/PDLIM5/TGFB1/CALR/FHL2/OBSL1 6 GO:0070585 protein localization to mitochondrion 6/852 125/18722 0.506149029017726 0.683407589449767 TSPO/RHOU/ISG15/LMAN1/PINK1/SH3GLB1 6 GO:1905037 autophagosome organization 5/852 103/18722 0.506346770062002 0.683407589449767 WIPI1/GBA/PINK1/SEC22B/SH3GLB1 5 GO:0021954 central nervous system neuron development 4/852 81/18722 0.506593841986507 0.683407589449767 GATA2/EPHB2/C12orf57/B4GALT5 4 GO:0044773 mitotic DNA damage checkpoint signaling 4/852 81/18722 0.506593841986507 0.683407589449767 SOX4/RPS27L/PLK2/TP53 4 GO:2000243 positive regulation of reproductive process 4/852 81/18722 0.506593841986507 0.683407589449767 CITED2/SYDE1/EDNRB/CTNNB1 4 GO:0001836 release of cytochrome c from mitochondria 3/852 59/18722 0.50686465129795 0.683407589449767 TNFSF10/PINK1/TP53 3 GO:0019369 arachidonic acid metabolic process 3/852 59/18722 0.50686465129795 0.683407589449767 MGLL/MAPK3/GPX4 3 GO:0051568 histone H3-K4 methylation 3/852 59/18722 0.50686465129795 0.683407589449767 GATA3/TET3/CTNNB1 3 GO:0002369 T cell cytokine production 2/852 37/18722 0.506886654364391 0.683407589449767 IL1R1/GATA3 2 GO:0002724 regulation of T cell cytokine production 2/852 37/18722 0.506886654364391 0.683407589449767 IL1R1/GATA3 2 GO:0003016 respiratory system process 2/852 37/18722 0.506886654364391 0.683407589449767 GAA/GLS 2 GO:0006623 protein targeting to vacuole 2/852 37/18722 0.506886654364391 0.683407589449767 SCARB2/LAMP2 2 GO:0006904 vesicle docking involved in exocytosis 2/852 37/18722 0.506886654364391 0.683407589449767 RAB8B/CTBP2 2 GO:0031646 positive regulation of nervous system process 2/852 37/18722 0.506886654364391 0.683407589449767 GBA/DAG1 2 GO:0033363 secretory granule organization 2/852 37/18722 0.506886654364391 0.683407589449767 SERPINE2/ABCA1 2 GO:0045730 respiratory burst 2/852 37/18722 0.506886654364391 0.683407589449767 GRN/INSR 2 GO:0046473 phosphatidic acid metabolic process 2/852 37/18722 0.506886654364391 0.683407589449767 LPCAT1/DGKZ 2 GO:0051294 establishment of spindle orientation 2/852 37/18722 0.506886654364391 0.683407589449767 ITGB1/MAP4 2 GO:0051954 positive regulation of amine transport 2/852 37/18722 0.506886654364391 0.683407589449767 ITGB1/PINK1 2 GO:0060419 heart growth 5/852 104/18722 0.514950733455267 0.694094012180064 NOG/CITED2/PDLIM5/TGFB2/TGFBR3 5 GO:0016575 histone deacetylation 4/852 82/18722 0.516290892270207 0.694931060718939 MORF4L2/HDAC5/PINK1/TP53 4 GO:0043242 negative regulation of protein-containing complex disassembly 4/852 82/18722 0.516290892270207 0.694931060718939 CAPG/LIMA1/ARHGEF2/GSN 4 GO:0046364 monosaccharide biosynthetic process 4/852 82/18722 0.516290892270207 0.694931060718939 FAM3C/ATF3/DDB1/ATF4 4 GO:0033866 nucleoside bisphosphate biosynthetic process 3/852 60/18722 0.518221998098448 0.694931060718939 TECR/ACSL4/ACSL3 3 GO:0034030 ribonucleoside bisphosphate biosynthetic process 3/852 60/18722 0.518221998098448 0.694931060718939 TECR/ACSL4/ACSL3 3 GO:0034033 purine nucleoside bisphosphate biosynthetic process 3/852 60/18722 0.518221998098448 0.694931060718939 TECR/ACSL4/ACSL3 3 GO:0051965 positive regulation of synapse assembly 3/852 60/18722 0.518221998098448 0.694931060718939 IL1RAP/EPHB2/TPBG 3 GO:0051048 negative regulation of secretion 8/852 171/18722 0.519302216574612 0.694931060718939 SFRP1/APOE/INHA/ERBB3/PPP3CA/FMR1/ERP29/FRMD4A 8 GO:0008210 estrogen metabolic process 2/852 38/18722 0.52123054546994 0.694931060718939 HSD3B1/PLEKHA1 2 GO:0009595 detection of biotic stimulus 2/852 38/18722 0.52123054546994 0.694931060718939 TSPO/SCARB1 2 GO:0010613 positive regulation of cardiac muscle hypertrophy 2/852 38/18722 0.52123054546994 0.694931060718939 IL6ST/PPP3CA 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/852 38/18722 0.52123054546994 0.694931060718939 ENG/ADM 2 GO:0046676 negative regulation of insulin secretion 2/852 38/18722 0.52123054546994 0.694931060718939 SFRP1/PPP3CA 2 GO:1903580 positive regulation of ATP metabolic process 2/852 38/18722 0.52123054546994 0.694931060718939 INSR/PINK1 2 GO:0006911 phagocytosis, engulfment 6/852 127/18722 0.521731212347505 0.694931060718939 GATA2/ABCA7/ABCA1/MYH9/GULP1/GSN 6 GO:0016079 synaptic vesicle exocytosis 5/852 105/18722 0.523491773029883 0.694931060718939 SYT8/STXBP5/SNAP23/CTBP2/FMR1 5 GO:0001574 ganglioside biosynthetic process 1/852 16/18722 0.525513136716924 0.694931060718939 B4GALT5 1 GO:0001845 phagolysosome assembly 1/852 16/18722 0.525513136716924 0.694931060718939 ARL8B 1 GO:0001977 renal system process involved in regulation of blood volume 1/852 16/18722 0.525513136716924 0.694931060718939 GJA5 1 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 1/852 16/18722 0.525513136716924 0.694931060718939 CTSZ 1 GO:0002371 dendritic cell cytokine production 1/852 16/18722 0.525513136716924 0.694931060718939 BST2 1 GO:0002713 negative regulation of B cell mediated immunity 1/852 16/18722 0.525513136716924 0.694931060718939 NDFIP1 1 GO:0002827 positive regulation of T-helper 1 type immune response 1/852 16/18722 0.525513136716924 0.694931060718939 IL1R1 1 GO:0002830 positive regulation of type 2 immune response 1/852 16/18722 0.525513136716924 0.694931060718939 GATA3 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/852 16/18722 0.525513136716924 0.694931060718939 NDFIP1 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/852 16/18722 0.525513136716924 0.694931060718939 CAMK2N1 1 GO:0006004 fucose metabolic process 1/852 16/18722 0.525513136716924 0.694931060718939 FUCA2 1 GO:0006206 pyrimidine nucleobase metabolic process 1/852 16/18722 0.525513136716924 0.694931060718939 CMPK1 1 GO:0006349 regulation of gene expression by genetic imprinting 1/852 16/18722 0.525513136716924 0.694931060718939 IGF2 1 GO:0006828 manganese ion transport 1/852 16/18722 0.525513136716924 0.694931060718939 SLC39A8 1 GO:0006857 oligopeptide transport 1/852 16/18722 0.525513136716924 0.694931060718939 SLC15A3 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/852 16/18722 0.525513136716924 0.694931060718939 XIST 1 GO:0010225 response to UV-C 1/852 16/18722 0.525513136716924 0.694931060718939 TP53 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/852 16/18722 0.525513136716924 0.694931060718939 PTK2B 1 GO:0017014 protein nitrosylation 1/852 16/18722 0.525513136716924 0.694931060718939 TXN 1 GO:0018119 peptidyl-cysteine S-nitrosylation 1/852 16/18722 0.525513136716924 0.694931060718939 TXN 1 GO:0019081 viral translation 1/852 16/18722 0.525513136716924 0.694931060718939 PCBP2 1 GO:0021783 preganglionic parasympathetic fiber development 1/852 16/18722 0.525513136716924 0.694931060718939 NAV2 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 1/852 16/18722 0.525513136716924 0.694931060718939 ITGA5 1 GO:0032274 gonadotropin secretion 1/852 16/18722 0.525513136716924 0.694931060718939 INHA 1 GO:0034138 toll-like receptor 3 signaling pathway 1/852 16/18722 0.525513136716924 0.694931060718939 TNFAIP3 1 GO:0036342 post-anal tail morphogenesis 1/852 16/18722 0.525513136716924 0.694931060718939 TMED2 1 GO:0042407 cristae formation 1/852 16/18722 0.525513136716924 0.694931060718939 PINK1 1 GO:0042574 retinal metabolic process 1/852 16/18722 0.525513136716924 0.694931060718939 RDH10 1 GO:0042795 snRNA transcription by RNA polymerase II 1/852 16/18722 0.525513136716924 0.694931060718939 ELL2 1 GO:0044065 regulation of respiratory system process 1/852 16/18722 0.525513136716924 0.694931060718939 GLS 1 GO:0044804 autophagy of nucleus 1/852 16/18722 0.525513136716924 0.694931060718939 WIPI1 1 GO:0045342 MHC class II biosynthetic process 1/852 16/18722 0.525513136716924 0.694931060718939 XBP1 1 GO:0045651 positive regulation of macrophage differentiation 1/852 16/18722 0.525513136716924 0.694931060718939 TGFB1 1 GO:0045721 negative regulation of gluconeogenesis 1/852 16/18722 0.525513136716924 0.694931060718939 FAM3C 1 GO:0045722 positive regulation of gluconeogenesis 1/852 16/18722 0.525513136716924 0.694931060718939 DDB1 1 GO:0045838 positive regulation of membrane potential 1/852 16/18722 0.525513136716924 0.694931060718939 GLRX 1 GO:0046037 GMP metabolic process 1/852 16/18722 0.525513136716924 0.694931060718939 TJP2 1 GO:0050884 neuromuscular process controlling posture 1/852 16/18722 0.525513136716924 0.694931060718939 GAA 1 GO:0061548 ganglion development 1/852 16/18722 0.525513136716924 0.694931060718939 CTNNB1 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/852 16/18722 0.525513136716924 0.694931060718939 TP53 1 GO:0070365 hepatocyte differentiation 1/852 16/18722 0.525513136716924 0.694931060718939 KRT18 1 GO:0070571 negative regulation of neuron projection regeneration 1/852 16/18722 0.525513136716924 0.694931060718939 PTPRS 1 GO:0071391 cellular response to estrogen stimulus 1/852 16/18722 0.525513136716924 0.694931060718939 SFRP1 1 GO:0071732 cellular response to nitric oxide 1/852 16/18722 0.525513136716924 0.694931060718939 DNM2 1 GO:0072109 glomerular mesangium development 1/852 16/18722 0.525513136716924 0.694931060718939 EGR1 1 GO:0072283 metanephric renal vesicle morphogenesis 1/852 16/18722 0.525513136716924 0.694931060718939 CTNNB1 1 GO:0090336 positive regulation of brown fat cell differentiation 1/852 16/18722 0.525513136716924 0.694931060718939 RREB1 1 GO:0097202 activation of cysteine-type endopeptidase activity 1/852 16/18722 0.525513136716924 0.694931060718939 TBC1D10A 1 GO:0099010 modification of postsynaptic structure 1/852 16/18722 0.525513136716924 0.694931060718939 TIAM1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/852 16/18722 0.525513136716924 0.694931060718939 PIK3CB 1 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/852 16/18722 0.525513136716924 0.694931060718939 MIF 1 GO:1902931 negative regulation of alcohol biosynthetic process 1/852 16/18722 0.525513136716924 0.694931060718939 APOE 1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1/852 16/18722 0.525513136716924 0.694931060718939 SFRP1 1 GO:2000765 regulation of cytoplasmic translation 1/852 16/18722 0.525513136716924 0.694931060718939 FMR1 1 GO:2000846 regulation of corticosteroid hormone secretion 1/852 16/18722 0.525513136716924 0.694931060718939 POMC 1 GO:2001212 regulation of vasculogenesis 1/852 16/18722 0.525513136716924 0.694931060718939 ADM 1 GO:0031397 negative regulation of protein ubiquitination 4/852 83/18722 0.525898278949937 0.695257693184931 TSPO/SOX4/ISG15/TNFAIP3 4 GO:0001959 regulation of cytokine-mediated signaling pathway 7/852 150/18722 0.527512819637915 0.697209039190553 IL1R1/IL1R2/ISG15/TNFAIP3/STAT2/UBE2K/ADAM17 7 GO:0019748 secondary metabolic process 3/852 61/18722 0.529436475159927 0.698850629564915 PAM/OPN3/MFSD12 3 GO:0043030 regulation of macrophage activation 3/852 61/18722 0.529436475159927 0.698850629564915 GRN/LDLR/MIF 3 GO:0043966 histone H3 acetylation 3/852 61/18722 0.529436475159927 0.698850629564915 GATA3/TAF5L/JADE1 3 GO:1904356 regulation of telomere maintenance via telomere lengthening 3/852 61/18722 0.529436475159927 0.698850629564915 TNKS2/CTNNB1/MAPK3 3 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 6/852 128/18722 0.529449125875426 0.698850629564915 TGFB2/PTK2B/SEMA4C/SASH1/RNF13/EMC10 6 GO:1901605 alpha-amino acid metabolic process 9/852 195/18722 0.530957872407481 0.700658356535619 PLOD3/PLOD2/PIPOX/PYCR1/SLC39A8/GFPT1/GLS/SERINC3/ATF4 9 GO:0046620 regulation of organ growth 5/852 106/18722 0.531967098568234 0.701806135542312 IGF2/NOG/CITED2/WWC3/TGFBR3 5 GO:0001914 regulation of T cell mediated cytotoxicity 2/852 39/18722 0.535291919345408 0.70413662917209 HLA-G/PVR 2 GO:0014742 positive regulation of muscle hypertrophy 2/852 39/18722 0.535291919345408 0.70413662917209 IL6ST/PPP3CA 2 GO:0016233 telomere capping 2/852 39/18722 0.535291919345408 0.70413662917209 TNKS2/MAPK3 2 GO:0031507 heterochromatin assembly 2/852 39/18722 0.535291919345408 0.70413662917209 MBD2/MBD3 2 GO:0042417 dopamine metabolic process 2/852 39/18722 0.535291919345408 0.70413662917209 MAOA/TGFB2 2 GO:0051154 negative regulation of striated muscle cell differentiation 2/852 39/18722 0.535291919345408 0.70413662917209 XBP1/HDAC5 2 GO:0009953 dorsal/ventral pattern formation 4/852 84/18722 0.535412453773413 0.70413662917209 NOG/SFRP1/ACVRL1/CTNNB1 4 GO:0010660 regulation of muscle cell apoptotic process 4/852 84/18722 0.535412453773413 0.70413662917209 PTK2B/CAPN2/TP53/MDK 4 GO:0015844 monoamine transport 4/852 84/18722 0.535412453773413 0.70413662917209 SYT8/SLC6A2/ACTB/PINK1 4 GO:0042440 pigment metabolic process 4/852 84/18722 0.535412453773413 0.70413662917209 TSPO/PGRMC1/OPN3/MFSD12 4 GO:0098586 cellular response to virus 4/852 84/18722 0.535412453773413 0.70413662917209 SMAD3/VWCE/SEC14L1/FMR1 4 GO:1900542 regulation of purine nucleotide metabolic process 4/852 84/18722 0.535412453773413 0.70413662917209 PRKAG2/GUCA2A/INSR/PINK1 4 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5/852 107/18722 0.540374053109784 0.708432668458047 HLA-G/IL1R1/GATA3/TGFB1/PVR 5 GO:0006275 regulation of DNA replication 5/852 107/18722 0.540374053109784 0.708432668458047 ACVRL1/ID3/BCAR3/TP53/ZBTB38 5 GO:0021761 limbic system development 5/852 107/18722 0.540374053109784 0.708432668458047 HSD3B1/PTPRS/MFSD2A/NCOA1/MDK 5 GO:0007588 excretion 3/852 62/18722 0.54050359528498 0.708432668458047 EDNRB/MDK/NFAT5 3 GO:0010573 vascular endothelial growth factor production 3/852 62/18722 0.54050359528498 0.708432668458047 IL6ST/TGFB1/ATF4 3 GO:0019933 cAMP-mediated signaling 3/852 62/18722 0.54050359528498 0.708432668458047 ADM/POMC/EIF4EBP2 3 GO:0031124 mRNA 3'-end processing 3/852 62/18722 0.54050359528498 0.708432668458047 PABPC1/ZFP36L1/SYMPK 3 GO:0032623 interleukin-2 production 3/852 62/18722 0.54050359528498 0.708432668458047 GATA3/TNFAIP3/EZR 3 GO:0032663 regulation of interleukin-2 production 3/852 62/18722 0.54050359528498 0.708432668458047 GATA3/TNFAIP3/EZR 3 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 3/852 62/18722 0.54050359528498 0.708432668458047 GPC4/ADAM10/DAG1 3 GO:0051480 regulation of cytosolic calcium ion concentration 16/852 353/18722 0.543063247648146 0.708432668458047 ADM/GATA2/SMAD3/PTK2B/CCR1/EDNRB/UBASH3B/CAV2/LRP1/ACKR2/ITPR2/P2RX4/NPTN/ERO1A/TMBIM6/SRI 16 GO:0051028 mRNA transport 6/852 130/18722 0.544727804542552 0.708432668458047 IGF2BP2/ZFP36L1/ZC3H11A/FMR1/MYO1C/IGF2BP3 6 GO:0002709 regulation of T cell mediated immunity 4/852 85/18722 0.544830092693243 0.708432668458047 HLA-G/IL1R1/GATA3/PVR 4 GO:0009142 nucleoside triphosphate biosynthetic process 4/852 85/18722 0.544830092693243 0.708432668458047 PRKAG2/TGFB1/PINK1/CMPK1 4 GO:0044774 mitotic DNA integrity checkpoint signaling 4/852 85/18722 0.544830092693243 0.708432668458047 SOX4/RPS27L/PLK2/TP53 4 GO:0045069 regulation of viral genome replication 4/852 85/18722 0.544830092693243 0.708432668458047 ISG15/PABPC1/BST2/DDB1 4 GO:0072384 organelle transport along microtubule 4/852 85/18722 0.544830092693243 0.708432668458047 AP3S1/LAMP1/SUN2/COPG1 4 GO:0001780 neutrophil homeostasis 1/852 17/18722 0.547124534531378 0.708432668458047 PIK3CB 1 GO:0001829 trophectodermal cell differentiation 1/852 17/18722 0.547124534531378 0.708432668458047 CITED2 1 GO:0006474 N-terminal protein amino acid acetylation 1/852 17/18722 0.547124534531378 0.708432668458047 SOX4 1 GO:0006895 Golgi to endosome transport 1/852 17/18722 0.547124534531378 0.708432668458047 WIPI1 1 GO:0007351 tripartite regional subdivision 1/852 17/18722 0.547124534531378 0.708432668458047 PCSK6 1 GO:0008595 anterior/posterior axis specification, embryo 1/852 17/18722 0.547124534531378 0.708432668458047 PCSK6 1 GO:0016264 gap junction assembly 1/852 17/18722 0.547124534531378 0.708432668458047 GJA5 1 GO:0020027 hemoglobin metabolic process 1/852 17/18722 0.547124534531378 0.708432668458047 INHA 1 GO:0030322 stabilization of membrane potential 1/852 17/18722 0.547124534531378 0.708432668458047 KCNK12 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/852 17/18722 0.547124534531378 0.708432668458047 TMEM50A 1 GO:0033623 regulation of integrin activation 1/852 17/18722 0.547124534531378 0.708432668458047 FBLIM1 1 GO:0034349 glial cell apoptotic process 1/852 17/18722 0.547124534531378 0.708432668458047 TP53 1 GO:0035518 histone H2A monoubiquitination 1/852 17/18722 0.547124534531378 0.708432668458047 DDB1 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/852 17/18722 0.547124534531378 0.708432668458047 PIK3CB 1 GO:0042953 lipoprotein transport 1/852 17/18722 0.547124534531378 0.708432668458047 LRP1 1 GO:0043950 positive regulation of cAMP-mediated signaling 1/852 17/18722 0.547124534531378 0.708432668458047 POMC 1 GO:0043968 histone H2A acetylation 1/852 17/18722 0.547124534531378 0.708432668458047 MORF4L2 1 GO:0044539 long-chain fatty acid import into cell 1/852 17/18722 0.547124534531378 0.708432668458047 ACSL3 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/852 17/18722 0.547124534531378 0.708432668458047 FAT1 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/852 17/18722 0.547124534531378 0.708432668458047 HLA-G 1 GO:0046827 positive regulation of protein export from nucleus 1/852 17/18722 0.547124534531378 0.708432668458047 TCF7L2 1 GO:0046855 inositol phosphate dephosphorylation 1/852 17/18722 0.547124534531378 0.708432668458047 IMPA2 1 GO:0048339 paraxial mesoderm development 1/852 17/18722 0.547124534531378 0.708432668458047 SMAD3 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/852 17/18722 0.547124534531378 0.708432668458047 SYT8 1 GO:0051580 regulation of neurotransmitter uptake 1/852 17/18722 0.547124534531378 0.708432668458047 ITGB1 1 GO:0051797 regulation of hair follicle development 1/852 17/18722 0.547124534531378 0.708432668458047 TGFB2 1 GO:0055003 cardiac myofibril assembly 1/852 17/18722 0.547124534531378 0.708432668458047 OBSL1 1 GO:0055064 chloride ion homeostasis 1/852 17/18722 0.547124534531378 0.708432668458047 SLC12A8 1 GO:0055083 monovalent inorganic anion homeostasis 1/852 17/18722 0.547124534531378 0.708432668458047 SLC12A8 1 GO:0060033 anatomical structure regression 1/852 17/18722 0.547124534531378 0.708432668458047 FLT1 1 GO:0060644 mammary gland epithelial cell differentiation 1/852 17/18722 0.547124534531378 0.708432668458047 ZNF703 1 GO:0060977 coronary vasculature morphogenesis 1/852 17/18722 0.547124534531378 0.708432668458047 TGFBR3 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/852 17/18722 0.547124534531378 0.708432668458047 ZFP36L1 1 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 1/852 17/18722 0.547124534531378 0.708432668458047 SESTD1 1 GO:0070293 renal absorption 1/852 17/18722 0.547124534531378 0.708432668458047 GSN 1 GO:0071816 tail-anchored membrane protein insertion into ER membrane 1/852 17/18722 0.547124534531378 0.708432668458047 EMC10 1 GO:0090036 regulation of protein kinase C signaling 1/852 17/18722 0.547124534531378 0.708432668458047 MYADM 1 GO:0090494 dopamine uptake 1/852 17/18722 0.547124534531378 0.708432668458047 SLC6A2 1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 1/852 17/18722 0.547124534531378 0.708432668458047 DLGAP4 1 GO:0140354 lipid import into cell 1/852 17/18722 0.547124534531378 0.708432668458047 ACSL3 1 GO:1901569 fatty acid derivative catabolic process 1/852 17/18722 0.547124534531378 0.708432668458047 HPGD 1 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 1/852 17/18722 0.547124534531378 0.708432668458047 TGFB1 1 GO:1903830 magnesium ion transmembrane transport 1/852 17/18722 0.547124534531378 0.708432668458047 MAGT1 1 GO:0051607 defense response to virus 12/852 265/18722 0.548863487908546 0.708941251823857 HTRA1/IFI27/ISG15/TNFAIP3/IFNGR2/STAT2/BST2/SERINC3/SEC14L1/PCBP2/DDX17/DNAJC3 12 GO:0140546 defense response to symbiont 12/852 265/18722 0.548863487908546 0.708941251823857 HTRA1/IFI27/ISG15/TNFAIP3/IFNGR2/STAT2/BST2/SERINC3/SEC14L1/PCBP2/DDX17/DNAJC3 12 GO:0007339 binding of sperm to zona pellucida 2/852 40/18722 0.54906675931043 0.708941251823857 B4GALT1/LY6K 2 GO:0031111 negative regulation of microtubule polymerization or depolymerization 2/852 40/18722 0.54906675931043 0.708941251823857 ARHGEF2/ARHGEF7 2 GO:0032094 response to food 2/852 40/18722 0.54906675931043 0.708941251823857 NUCB2/SLC16A1 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/852 40/18722 0.54906675931043 0.708941251823857 PTPRS/TNFAIP3 2 GO:0055081 anion homeostasis 2/852 40/18722 0.54906675931043 0.708941251823857 SLC12A8/GLS 2 GO:0071276 cellular response to cadmium ion 2/852 40/18722 0.54906675931043 0.708941251823857 MT1X/MAPK3 2 GO:0150077 regulation of neuroinflammatory response 2/852 40/18722 0.54906675931043 0.708941251823857 GRN/LDLR 2 GO:1901998 toxin transport 2/852 40/18722 0.54906675931043 0.708941251823857 ADAM10/ANTXR2 2 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 2/852 40/18722 0.54906675931043 0.708941251823857 MDK/NFAT5 2 GO:0002704 negative regulation of leukocyte mediated immunity 3/852 63/18722 0.551419298702212 0.711613674453392 HLA-G/BST2/NDFIP1 3 GO:1902373 negative regulation of mRNA catabolic process 3/852 63/18722 0.551419298702212 0.711613674453392 PABPC1/FMR1/PKP3 3 GO:0006816 calcium ion transport 19/852 422/18722 0.552788805935725 0.713198169770445 RRAD/TSPO/PTK2B/SESTD1/CCR1/WFS1/CTNNB1/UBASH3B/SEC61A1/LGALS3/PPP3CA/ITPR2/P2RX4/ERO1A/TMBIM6/AHNAK/FMR1/TMCO1/SRI 19 GO:0006140 regulation of nucleotide metabolic process 4/852 86/18722 0.554148091241445 0.714585535029001 PRKAG2/GUCA2A/INSR/PINK1 4 GO:0032413 negative regulation of ion transmembrane transporter activity 4/852 86/18722 0.554148091241445 0.714585535029001 RRAD/EPHB2/FMR1/SRI 4 GO:0051168 nuclear export 7/852 154/18722 0.555624240366997 0.716305533239522 TCF7L2/IFI27/TGFB1/CALR/TXN/XPOT/ZC3H11A 7 GO:0002456 T cell mediated immunity 5/852 109/18722 0.556972879808864 0.717492834419762 HLA-G/IL1R1/GATA3/PVR/CTSH 5 GO:0006821 chloride transport 5/852 109/18722 0.556972879808864 0.717492834419762 TSPO/SLC12A8/CLIC4/PCYOX1/SLC1A3 5 GO:0034766 negative regulation of ion transmembrane transport 5/852 109/18722 0.556972879808864 0.717492834419762 RRAD/EPHB2/SESTD1/FMR1/SRI 5 GO:0051302 regulation of cell division 8/852 177/18722 0.558773610299297 0.719628347143388 IGF2/PTN/TGFB1/TGFB2/PGF/PLK2/MDK/SH3GLB1 8 GO:0030858 positive regulation of epithelial cell differentiation 3/852 64/18722 0.562179936082175 0.720953264305482 SERPINE1/ACVRL1/CTNNB1 3 GO:0046888 negative regulation of hormone secretion 3/852 64/18722 0.562179936082175 0.720953264305482 SFRP1/INHA/PPP3CA 3 GO:0048247 lymphocyte chemotaxis 3/852 64/18722 0.562179936082175 0.720953264305482 PTK2B/ADAM10/ADAM17 3 GO:0070542 response to fatty acid 3/852 64/18722 0.562179936082175 0.720953264305482 LPL/ID3/LDLR 3 GO:0098930 axonal transport 3/852 64/18722 0.562179936082175 0.720953264305482 HSPB1/AP3S1/ARL8B 3 GO:0046434 organophosphate catabolic process 7/852 155/18722 0.562537490693616 0.720953264305482 APOC1/PLA2G7/GDPD3/SCARB1/LIPG/LDLR/IMPA2 7 GO:0032735 positive regulation of interleukin-12 production 2/852 41/18722 0.562551997878545 0.720953264305482 HLA-G/MDK 2 GO:0051693 actin filament capping 2/852 41/18722 0.562551997878545 0.720953264305482 CAPG/GSN 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/852 41/18722 0.562551997878545 0.720953264305482 GUCA2A/PINK1 2 GO:0001776 leukocyte homeostasis 4/852 87/18722 0.56336355968514 0.720953264305482 TNFAIP3/PKN1/PIK3CB/ADAM17 4 GO:0035725 sodium ion transmembrane transport 8/852 178/18722 0.565219039496402 0.720953264305482 SLC4A7/SLC6A2/FXYD5/GLRX/DNM2/ACTN4/SLC6A8/PTPN3 8 GO:0016236 macroautophagy 13/852 291/18722 0.567489215279913 0.720953264305482 QSOX1/WIPI1/GBA/ATP6V0E1/PINK1/PAFAH1B2/MAPK3/ARL8B/TP53/RHEB/SEC22B/LAMP2/SH3GLB1 13 GO:0002076 osteoblast development 1/852 18/18722 0.567752703287287 0.720953264305482 SMAD3 1 GO:0002283 neutrophil activation involved in immune response 1/852 18/18722 0.567752703287287 0.720953264305482 DNASE1L3 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/852 18/18722 0.567752703287287 0.720953264305482 CALR 1 GO:0003417 growth plate cartilage development 1/852 18/18722 0.567752703287287 0.720953264305482 COL27A1 1 GO:0006625 protein targeting to peroxisome 1/852 18/18722 0.567752703287287 0.720953264305482 RAB8B 1 GO:0007549 dosage compensation 1/852 18/18722 0.567752703287287 0.720953264305482 XIST 1 GO:0009068 aspartate family amino acid catabolic process 1/852 18/18722 0.567752703287287 0.720953264305482 PIPOX 1 GO:0009404 toxin metabolic process 1/852 18/18722 0.567752703287287 0.720953264305482 PAM 1 GO:0010985 negative regulation of lipoprotein particle clearance 1/852 18/18722 0.567752703287287 0.720953264305482 APOC1 1 GO:0030730 sequestering of triglyceride 1/852 18/18722 0.567752703287287 0.720953264305482 LPL 1 GO:0030889 negative regulation of B cell proliferation 1/852 18/18722 0.567752703287287 0.720953264305482 PKN1 1 GO:0031643 positive regulation of myelination 1/852 18/18722 0.567752703287287 0.720953264305482 DAG1 1 GO:0032095 regulation of response to food 1/852 18/18722 0.567752703287287 0.720953264305482 NUCB2 1 GO:0034134 toll-like receptor 2 signaling pathway 1/852 18/18722 0.567752703287287 0.720953264305482 TNFAIP3 1 GO:0035372 protein localization to microtubule 1/852 18/18722 0.567752703287287 0.720953264305482 MAPRE2 1 GO:0035930 corticosteroid hormone secretion 1/852 18/18722 0.567752703287287 0.720953264305482 POMC 1 GO:0043116 negative regulation of vascular permeability 1/852 18/18722 0.567752703287287 0.720953264305482 ADM 1 GO:0043217 myelin maintenance 1/852 18/18722 0.567752703287287 0.720953264305482 NDRG1 1 GO:0044872 lipoprotein localization 1/852 18/18722 0.567752703287287 0.720953264305482 LRP1 1 GO:0045116 protein neddylation 1/852 18/18722 0.567752703287287 0.720953264305482 EPAS1 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/852 18/18722 0.567752703287287 0.720953264305482 HLA-G 1 GO:0046112 nucleobase biosynthetic process 1/852 18/18722 0.567752703287287 0.720953264305482 CMPK1 1 GO:0046838 phosphorylated carbohydrate dephosphorylation 1/852 18/18722 0.567752703287287 0.720953264305482 IMPA2 1 GO:0048486 parasympathetic nervous system development 1/852 18/18722 0.567752703287287 0.720953264305482 NAV2 1 GO:0048535 lymph node development 1/852 18/18722 0.567752703287287 0.720953264305482 TGFB1 1 GO:0050665 hydrogen peroxide biosynthetic process 1/852 18/18722 0.567752703287287 0.720953264305482 ACOX1 1 GO:0060546 negative regulation of necroptotic process 1/852 18/18722 0.567752703287287 0.720953264305482 ARHGEF2 1 GO:0060602 branch elongation of an epithelium 1/852 18/18722 0.567752703287287 0.720953264305482 RDH10 1 GO:0060973 cell migration involved in heart development 1/852 18/18722 0.567752703287287 0.720953264305482 ENG 1 GO:0061687 detoxification of inorganic compound 1/852 18/18722 0.567752703287287 0.720953264305482 MT1X 1 GO:0072189 ureter development 1/852 18/18722 0.567752703287287 0.720953264305482 GATA3 1 GO:0072234 metanephric nephron tubule development 1/852 18/18722 0.567752703287287 0.720953264305482 WWTR1 1 GO:0072662 protein localization to peroxisome 1/852 18/18722 0.567752703287287 0.720953264305482 RAB8B 1 GO:0072663 establishment of protein localization to peroxisome 1/852 18/18722 0.567752703287287 0.720953264305482 RAB8B 1 GO:0080182 histone H3-K4 trimethylation 1/852 18/18722 0.567752703287287 0.720953264305482 TET3 1 GO:1900242 regulation of synaptic vesicle endocytosis 1/852 18/18722 0.567752703287287 0.720953264305482 SH3GL1 1 GO:1900424 regulation of defense response to bacterium 1/852 18/18722 0.567752703287287 0.720953264305482 GRN 1 GO:1901673 regulation of mitotic spindle assembly 1/852 18/18722 0.567752703287287 0.720953264305482 CCSAP 1 GO:1902170 cellular response to reactive nitrogen species 1/852 18/18722 0.567752703287287 0.720953264305482 DNM2 1 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1/852 18/18722 0.567752703287287 0.720953264305482 PIK3CB 1 GO:1903209 positive regulation of oxidative stress-induced cell death 1/852 18/18722 0.567752703287287 0.720953264305482 ENDOG 1 GO:2001135 regulation of endocytic recycling 1/852 18/18722 0.567752703287287 0.720953264305482 ARHGAP1 1 GO:0006473 protein acetylation 9/852 201/18722 0.567824108823154 0.720953264305482 GATA3/GATA2/SOX4/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 9 GO:0009952 anterior/posterior pattern specification 9/852 201/18722 0.567824108823154 0.720953264305482 NOG/SFRP1/SMAD3/PCSK6/TMED2/BMPR2/CTNNB1/TP53/ETS2 9 GO:1901991 negative regulation of mitotic cell cycle phase transition 8/852 179/18722 0.571622954833655 0.725593526274347 SOX4/RPS27L/PLK2/ZFP36L1/JADE1/CTDSP1/TP53/WEE1 8 GO:0009124 nucleoside monophosphate biosynthetic process 2/852 42/18722 0.575745438868361 0.729354843650757 RFK/CMPK1 2 GO:0030808 regulation of nucleotide biosynthetic process 2/852 42/18722 0.575745438868361 0.729354843650757 GUCA2A/PINK1 2 GO:0032689 negative regulation of interferon-gamma production 2/852 42/18722 0.575745438868361 0.729354843650757 GATA3/INHA 2 GO:0032691 negative regulation of interleukin-1 beta production 2/852 42/18722 0.575745438868361 0.729354843650757 TNFAIP3/ERRFI1 2 GO:0042168 heme metabolic process 2/852 42/18722 0.575745438868361 0.729354843650757 TSPO/PGRMC1 2 GO:0046596 regulation of viral entry into host cell 2/852 42/18722 0.575745438868361 0.729354843650757 P4HB/GSN 2 GO:1904037 positive regulation of epithelial cell apoptotic process 2/852 42/18722 0.575745438868361 0.729354843650757 HLA-G/GSN 2 GO:2000404 regulation of T cell migration 2/852 42/18722 0.575745438868361 0.729354843650757 ADAM10/ADAM17 2 GO:0010657 muscle cell apoptotic process 4/852 89/18722 0.58147639062753 0.735471946525033 PTK2B/CAPN2/TP53/MDK 4 GO:0009581 detection of external stimulus 6/852 135/18722 0.581917089687721 0.735471946525033 SERPINE2/CTNNB1/OPN3/PTK2/GNAQ/JUP 6 GO:0046626 regulation of insulin receptor signaling pathway 3/852 66/18722 0.58322336639181 0.735471946525033 IGF2/BAIAP2L1/PIK3R1 3 GO:0072678 T cell migration 3/852 66/18722 0.58322336639181 0.735471946525033 F11R/ADAM10/ADAM17 3 GO:1902476 chloride transmembrane transport 3/852 66/18722 0.58322336639181 0.735471946525033 SLC12A8/PCYOX1/SLC1A3 3 GO:0000028 ribosomal small subunit assembly 1/852 19/18722 0.587442325656792 0.735471946525033 RPS27L 1 GO:0002281 macrophage activation involved in immune response 1/852 19/18722 0.587442325656792 0.735471946525033 GRN 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/852 19/18722 0.587442325656792 0.735471946525033 HLA-G 1 GO:0006007 glucose catabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 TP53 1 GO:0006144 purine nucleobase metabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 TTR 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/852 19/18722 0.587442325656792 0.735471946525033 GNAQ 1 GO:0007530 sex determination 1/852 19/18722 0.587442325656792 0.735471946525033 CITED2 1 GO:0007603 phototransduction, visible light 1/852 19/18722 0.587442325656792 0.735471946525033 GNAQ 1 GO:0008356 asymmetric cell division 1/852 19/18722 0.587442325656792 0.735471946525033 ARHGEF2 1 GO:0009081 branched-chain amino acid metabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 BCAT1 1 GO:0009301 snRNA transcription 1/852 19/18722 0.587442325656792 0.735471946525033 ELL2 1 GO:0010002 cardioblast differentiation 1/852 19/18722 0.587442325656792 0.735471946525033 TGFB2 1 GO:0010738 regulation of protein kinase A signaling 1/852 19/18722 0.587442325656792 0.735471946525033 MIF 1 GO:0010744 positive regulation of macrophage derived foam cell differentiation 1/852 19/18722 0.587442325656792 0.735471946525033 LPL 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/852 19/18722 0.587442325656792 0.735471946525033 SERPINE2 1 GO:0015802 basic amino acid transport 1/852 19/18722 0.587442325656792 0.735471946525033 SLC7A1 1 GO:0031290 retinal ganglion cell axon guidance 1/852 19/18722 0.587442325656792 0.735471946525033 EPHB2 1 GO:0033194 response to hydroperoxide 1/852 19/18722 0.587442325656792 0.735471946525033 DAPK1 1 GO:0036498 IRE1-mediated unfolded protein response 1/852 19/18722 0.587442325656792 0.735471946525033 XBP1 1 GO:0043652 engulfment of apoptotic cell 1/852 19/18722 0.587442325656792 0.735471946525033 ABCA7 1 GO:0045019 negative regulation of nitric oxide biosynthetic process 1/852 19/18722 0.587442325656792 0.735471946525033 TSPO 1 GO:0045821 positive regulation of glycolytic process 1/852 19/18722 0.587442325656792 0.735471946525033 INSR 1 GO:0046653 tetrahydrofolate metabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 PIPOX 1 GO:0046716 muscle cell cellular homeostasis 1/852 19/18722 0.587442325656792 0.735471946525033 GAA 1 GO:0048245 eosinophil chemotaxis 1/852 19/18722 0.587442325656792 0.735471946525033 LGALS3 1 GO:0048490 anterograde synaptic vesicle transport 1/852 19/18722 0.587442325656792 0.735471946525033 AP3S1 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/852 19/18722 0.587442325656792 0.735471946525033 CTNNB1 1 GO:0051957 positive regulation of amino acid transport 1/852 19/18722 0.587442325656792 0.735471946525033 ITGB1 1 GO:0060039 pericardium development 1/852 19/18722 0.587442325656792 0.735471946525033 SMAD3 1 GO:0062099 negative regulation of programmed necrotic cell death 1/852 19/18722 0.587442325656792 0.735471946525033 ARHGEF2 1 GO:0070233 negative regulation of T cell apoptotic process 1/852 19/18722 0.587442325656792 0.735471946525033 EFNA1 1 GO:0070734 histone H3-K27 methylation 1/852 19/18722 0.587442325656792 0.735471946525033 GATA3 1 GO:0070989 oxidative demethylation 1/852 19/18722 0.587442325656792 0.735471946525033 TET3 1 GO:0071545 inositol phosphate catabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 IMPA2 1 GO:0072077 renal vesicle morphogenesis 1/852 19/18722 0.587442325656792 0.735471946525033 CTNNB1 1 GO:0097501 stress response to metal ion 1/852 19/18722 0.587442325656792 0.735471946525033 MT1X 1 GO:0099514 synaptic vesicle cytoskeletal transport 1/852 19/18722 0.587442325656792 0.735471946525033 AP3S1 1 GO:0099517 synaptic vesicle transport along microtubule 1/852 19/18722 0.587442325656792 0.735471946525033 AP3S1 1 GO:1901659 glycosyl compound biosynthetic process 1/852 19/18722 0.587442325656792 0.735471946525033 AMD1 1 GO:1904406 negative regulation of nitric oxide metabolic process 1/852 19/18722 0.587442325656792 0.735471946525033 TSPO 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/852 19/18722 0.587442325656792 0.735471946525033 BAIAP2L1 1 GO:2000831 regulation of steroid hormone secretion 1/852 19/18722 0.587442325656792 0.735471946525033 POMC 1 GO:0002861 regulation of inflammatory response to antigenic stimulus 2/852 43/18722 0.588645684624398 0.735514828876513 PLK2/FURIN 2 GO:0009268 response to pH 2/852 43/18722 0.588645684624398 0.735514828876513 PAM/GBA 2 GO:0021983 pituitary gland development 2/852 43/18722 0.588645684624398 0.735514828876513 NOG/GATA2 2 GO:0035794 positive regulation of mitochondrial membrane permeability 2/852 43/18722 0.588645684624398 0.735514828876513 TMEM14A/TP53 2 GO:0036230 granulocyte activation 2/852 43/18722 0.588645684624398 0.735514828876513 DNASE1L3/GRN 2 GO:0045840 positive regulation of mitotic nuclear division 2/852 43/18722 0.588645684624398 0.735514828876513 IGF2/INSR 2 GO:0090278 negative regulation of peptide hormone secretion 2/852 43/18722 0.588645684624398 0.735514828876513 SFRP1/PPP3CA 2 GO:0098815 modulation of excitatory postsynaptic potential 2/852 43/18722 0.588645684624398 0.735514828876513 PTK2B/SH3GL1 2 GO:0099024 plasma membrane invagination 6/852 136/18722 0.589168222041965 0.735802397403775 GATA2/ABCA7/ABCA1/MYH9/GULP1/GSN 6 GO:1903305 regulation of regulated secretory pathway 6/852 136/18722 0.589168222041965 0.735802397403775 SYT8/GATA2/STXBP5/LAMP1/AP1G1/FMR1 6 GO:1903169 regulation of calcium ion transmembrane transport 7/852 159/18722 0.589687368858532 0.736268054444305 RRAD/PTK2B/SESTD1/UBASH3B/AHNAK/FMR1/SRI 7 GO:0030901 midbrain development 4/852 90/18722 0.590369001221959 0.736753578762737 SFRP1/ACTB/CTNNB1/SEC16A 4 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 4/852 90/18722 0.590369001221959 0.736753578762737 TPM1/HPGD/ADAMTS1/MMP2 4 GO:0051260 protein homooligomerization 8/852 182/18722 0.590573800757955 0.736826459894593 HLA-G/KCNJ2/ATL3/VASP/SLC1A5/GLS/EVL/MIF 8 GO:0032890 regulation of organic acid transport 3/852 67/18722 0.593500761568837 0.739927999250918 ITGB1/PTGES/P2RX4 3 GO:0043967 histone H4 acetylation 3/852 67/18722 0.593500761568837 0.739927999250918 MORF4L2/NCOA1/JADE1 3 GO:1902117 positive regulation of organelle assembly 3/852 67/18722 0.593500761568837 0.739927999250918 SDC4/SDC1/SH3GLB1 3 GO:0007204 positive regulation of cytosolic calcium ion concentration 14/852 319/18722 0.594105462030716 0.740498462209161 ADM/GATA2/PTK2B/CCR1/EDNRB/UBASH3B/LRP1/ACKR2/ITPR2/P2RX4/NPTN/ERO1A/TMBIM6/SRI 14 GO:0060402 calcium ion transport into cytosol 7/852 160/18722 0.596342349076233 0.742932416303687 PTK2B/UBASH3B/ITPR2/P2RX4/ERO1A/TMBIM6/SRI 7 GO:0050684 regulation of mRNA processing 6/852 137/18722 0.596353459540412 0.742932416303687 MBNL2/ZFP36L1/RBFOX2/SRSF6/FMR1/DDX17 6 GO:0055006 cardiac cell development 4/852 91/18722 0.599149567108494 0.74604645503638 PDLIM5/FHL2/TGFBR3/OBSL1 4 GO:1990874 vascular associated smooth muscle cell proliferation 4/852 91/18722 0.599149567108494 0.74604645503638 TPM1/HPGD/ADAMTS1/MMP2 4 GO:0002792 negative regulation of peptide secretion 2/852 44/18722 0.6012520680447 0.74619370746626 SFRP1/PPP3CA 2 GO:0006378 mRNA polyadenylation 2/852 44/18722 0.6012520680447 0.74619370746626 PABPC1/SYMPK 2 GO:0006775 fat-soluble vitamin metabolic process 2/852 44/18722 0.6012520680447 0.74619370746626 CYP11A1/VKORC1 2 GO:0021517 ventral spinal cord development 2/852 44/18722 0.6012520680447 0.74619370746626 GATA2/SOX4 2 GO:0021762 substantia nigra development 2/852 44/18722 0.6012520680447 0.74619370746626 ACTB/SEC16A 2 GO:0031295 T cell costimulation 2/852 44/18722 0.6012520680447 0.74619370746626 EFNB1/DPP4 2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 2/852 44/18722 0.6012520680447 0.74619370746626 FAT1/ARF4 2 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 2/852 44/18722 0.6012520680447 0.74619370746626 CSH1/PTK2B 2 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 2/852 44/18722 0.6012520680447 0.74619370746626 RTN4/SLC15A3 2 GO:0009582 detection of abiotic stimulus 6/852 138/18722 0.603471399690068 0.74619370746626 SERPINE2/CTNNB1/OPN3/PTK2/GNAQ/JUP 6 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 6/852 138/18722 0.603471399690068 0.74619370746626 WFS1/CBLB/PINK1/NDFIP2/XIAP/NDFIP1 6 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 3/852 68/18722 0.603612262301562 0.74619370746626 PRKAG2/TGFB1/PINK1 3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 3/852 68/18722 0.603612262301562 0.74619370746626 IL6ST/CSH1/CSF1R 3 GO:0046686 response to cadmium ion 3/852 68/18722 0.603612262301562 0.74619370746626 SPARC/MT1X/MAPK3 3 GO:0061912 selective autophagy 3/852 68/18722 0.603612262301562 0.74619370746626 PINK1/MAPK3/TP53 3 GO:0016197 endosomal transport 10/852 230/18722 0.604073634136523 0.74619370746626 REPS2/ANKRD50/ABCA1/PICALM/CLN5/TMEM50A/TBC1D10A/ARHGAP1/RHOBTB3/ARL8B 10 GO:0051209 release of sequestered calcium ion into cytosol 5/852 115/18722 0.604892311083008 0.74619370746626 PTK2B/UBASH3B/ITPR2/ERO1A/SRI 5 GO:0002834 regulation of response to tumor cell 1/852 20/18722 0.606236055996332 0.74619370746626 PVR 1 GO:0002837 regulation of immune response to tumor cell 1/852 20/18722 0.606236055996332 0.74619370746626 PVR 1 GO:0006525 arginine metabolic process 1/852 20/18722 0.606236055996332 0.74619370746626 SLC39A8 1 GO:0006607 NLS-bearing protein import into nucleus 1/852 20/18722 0.606236055996332 0.74619370746626 CBLB 1 GO:0006883 cellular sodium ion homeostasis 1/852 20/18722 0.606236055996332 0.74619370746626 SLC1A3 1 GO:0007097 nuclear migration 1/852 20/18722 0.606236055996332 0.74619370746626 SUN2 1 GO:0007194 negative regulation of adenylate cyclase activity 1/852 20/18722 0.606236055996332 0.74619370746626 EDNRB 1 GO:0009110 vitamin biosynthetic process 1/852 20/18722 0.606236055996332 0.74619370746626 RFK 1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 1/852 20/18722 0.606236055996332 0.74619370746626 CMPK1 1 GO:0010893 positive regulation of steroid biosynthetic process 1/852 20/18722 0.606236055996332 0.74619370746626 ADM 1 GO:0015919 peroxisomal membrane transport 1/852 20/18722 0.606236055996332 0.74619370746626 RAB8B 1 GO:0031645 negative regulation of nervous system process 1/852 20/18722 0.606236055996332 0.74619370746626 JAM2 1 GO:0032930 positive regulation of superoxide anion generation 1/852 20/18722 0.606236055996332 0.74619370746626 TGFB1 1 GO:0033005 positive regulation of mast cell activation 1/852 20/18722 0.606236055996332 0.74619370746626 GATA2 1 GO:0039535 regulation of RIG-I signaling pathway 1/852 20/18722 0.606236055996332 0.74619370746626 SEC14L1 1 GO:0042359 vitamin D metabolic process 1/852 20/18722 0.606236055996332 0.74619370746626 CYP11A1 1 GO:0043011 myeloid dendritic cell differentiation 1/852 20/18722 0.606236055996332 0.74619370746626 NOTCH2 1 GO:0043586 tongue development 1/852 20/18722 0.606236055996332 0.74619370746626 CTNNB1 1 GO:0046485 ether lipid metabolic process 1/852 20/18722 0.606236055996332 0.74619370746626 PLA2G7 1 GO:0046629 gamma-delta T cell activation 1/852 20/18722 0.606236055996332 0.74619370746626 SOX4 1 GO:0048025 negative regulation of mRNA splicing, via spliceosome 1/852 20/18722 0.606236055996332 0.74619370746626 SRSF6 1 GO:0051900 regulation of mitochondrial depolarization 1/852 20/18722 0.606236055996332 0.74619370746626 TSPO 1 GO:0060252 positive regulation of glial cell proliferation 1/852 20/18722 0.606236055996332 0.74619370746626 TSPO 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/852 20/18722 0.606236055996332 0.74619370746626 TIAM1 1 GO:0070932 histone H3 deacetylation 1/852 20/18722 0.606236055996332 0.74619370746626 HDAC5 1 GO:0071379 cellular response to prostaglandin stimulus 1/852 20/18722 0.606236055996332 0.74619370746626 SFRP1 1 GO:0072087 renal vesicle development 1/852 20/18722 0.606236055996332 0.74619370746626 CTNNB1 1 GO:0097503 sialylation 1/852 20/18722 0.606236055996332 0.74619370746626 ST3GAL6 1 GO:2000010 positive regulation of protein localization to cell surface 1/852 20/18722 0.606236055996332 0.74619370746626 ABCA7 1 GO:2000678 negative regulation of transcription regulatory region DNA binding 1/852 20/18722 0.606236055996332 0.74619370746626 SRI 1 GO:1903312 negative regulation of mRNA metabolic process 4/852 92/18722 0.607816193776402 0.747955722072526 PABPC1/SRSF6/FMR1/PKP3 4 GO:0006836 neurotransmitter transport 9/852 208/18722 0.609183002843892 0.749454425156028 ITGB1/SYT8/SLC6A2/STXBP5/SNAP23/CTBP2/SLC6A8/SLC1A3/FMR1 9 GO:0060759 regulation of response to cytokine stimulus 7/852 162/18722 0.609484750001637 0.749642411231241 IL1R1/IL1R2/ISG15/TNFAIP3/STAT2/UBE2K/ADAM17 7 GO:0009165 nucleotide biosynthetic process 11/852 254/18722 0.610181374755706 0.750315870790489 PRKAG2/GUCA2A/TGFB1/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/RFK/CMPK1/ACSL3 11 GO:0018107 peptidyl-threonine phosphorylation 5/852 116/18722 0.612585592576013 0.752270542530475 PRKAG2/TGFB1/PKN1/HIPK3/UBE2K 5 GO:0051283 negative regulation of sequestering of calcium ion 5/852 116/18722 0.612585592576013 0.752270542530475 PTK2B/UBASH3B/ITPR2/ERO1A/SRI 5 GO:0007004 telomere maintenance via telomerase 3/852 69/18722 0.613556021538463 0.752270542530475 TNKS2/CTNNB1/MAPK3 3 GO:0009145 purine nucleoside triphosphate biosynthetic process 3/852 69/18722 0.613556021538463 0.752270542530475 PRKAG2/TGFB1/PINK1 3 GO:0050805 negative regulation of synaptic transmission 3/852 69/18722 0.613556021538463 0.752270542530475 PTK2B/PLK2/FMR1 3 GO:0051966 regulation of synaptic transmission, glutamatergic 3/852 69/18722 0.613556021538463 0.752270542530475 SERPINE2/PTK2B/DGKZ 3 GO:0002920 regulation of humoral immune response 2/852 45/18722 0.613564589129267 0.752270542530475 SERPING1/CD59 2 GO:0006110 regulation of glycolytic process 2/852 45/18722 0.613564589129267 0.752270542530475 PRKAG2/INSR 2 GO:0032309 icosanoid secretion 2/852 45/18722 0.613564589129267 0.752270542530475 PTGES/P2RX4 2 GO:0043631 RNA polyadenylation 2/852 45/18722 0.613564589129267 0.752270542530475 PABPC1/SYMPK 2 GO:0048599 oocyte development 2/852 45/18722 0.613564589129267 0.752270542530475 PTK2B/CTNNB1 2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 2/852 45/18722 0.613564589129267 0.752270542530475 TMEM14A/TP53 2 GO:0050657 nucleic acid transport 7/852 163/18722 0.61596995228909 0.754603737002512 IGF2BP2/ZFP36L1/XPOT/ZC3H11A/FMR1/MYO1C/IGF2BP3 7 GO:0050658 RNA transport 7/852 163/18722 0.61596995228909 0.754603737002512 IGF2BP2/ZFP36L1/XPOT/ZC3H11A/FMR1/MYO1C/IGF2BP3 7 GO:0032088 negative regulation of NF-kappaB transcription factor activity 4/852 93/18722 0.616367169246439 0.754603737002512 TNFAIP3/ANXA4/DAP/NLRP2 4 GO:0032755 positive regulation of interleukin-6 production 4/852 93/18722 0.616367169246439 0.754603737002512 IL1RAP/LPL/XBP1/ARHGEF2 4 GO:0033273 response to vitamin 4/852 93/18722 0.616367169246439 0.754603737002512 SPARC/SFRP1/PTN/TSPO 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 4/852 93/18722 0.616367169246439 0.754603737002512 RRAD/AHNAK/FMR1/SRI 4 GO:1901293 nucleoside phosphate biosynthetic process 11/852 256/18722 0.620565919759654 0.757528532381629 PRKAG2/GUCA2A/TGFB1/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/RFK/CMPK1/ACSL3 11 GO:0000002 mitochondrial genome maintenance 1/852 21/18722 0.624174612316037 0.757528532381629 TP53 1 GO:0003091 renal water homeostasis 1/852 21/18722 0.624174612316037 0.757528532381629 WFS1 1 GO:0007063 regulation of sister chromatid cohesion 1/852 21/18722 0.624174612316037 0.757528532381629 CTNNB1 1 GO:0007252 I-kappaB phosphorylation 1/852 21/18722 0.624174612316037 0.757528532381629 PRDX4 1 GO:0007350 blastoderm segmentation 1/852 21/18722 0.624174612316037 0.757528532381629 PCSK6 1 GO:0009070 serine family amino acid biosynthetic process 1/852 21/18722 0.624174612316037 0.757528532381629 SERINC3 1 GO:0010766 negative regulation of sodium ion transport 1/852 21/18722 0.624174612316037 0.757528532381629 SERPINE2 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/852 21/18722 0.624174612316037 0.757528532381629 CNPY2 1 GO:0019985 translesion synthesis 1/852 21/18722 0.624174612316037 0.757528532381629 FAAP20 1 GO:0023019 signal transduction involved in regulation of gene expression 1/852 21/18722 0.624174612316037 0.757528532381629 SMAD3 1 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 1/852 21/18722 0.624174612316037 0.757528532381629 SNAP23 1 GO:0031998 regulation of fatty acid beta-oxidation 1/852 21/18722 0.624174612316037 0.757528532381629 MFSD2A 1 GO:0032482 Rab protein signal transduction 1/852 21/18722 0.624174612316037 0.757528532381629 SGSM3 1 GO:0034312 diol biosynthetic process 1/852 21/18722 0.624174612316037 0.757528532381629 GBA 1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 1/852 21/18722 0.624174612316037 0.757528532381629 NCKAP1 1 GO:0035330 regulation of hippo signaling 1/852 21/18722 0.624174612316037 0.757528532381629 WWC3 1 GO:0035813 regulation of renal sodium excretion 1/852 21/18722 0.624174612316037 0.757528532381629 EDNRB 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/852 21/18722 0.624174612316037 0.757528532381629 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/852 21/18722 0.624174612316037 0.757528532381629 GLS 1 GO:0045655 regulation of monocyte differentiation 1/852 21/18722 0.624174612316037 0.757528532381629 ZFP36L1 1 GO:0046128 purine ribonucleoside metabolic process 1/852 21/18722 0.624174612316037 0.757528532381629 AMD1 1 GO:0046597 negative regulation of viral entry into host cell 1/852 21/18722 0.624174612316037 0.757528532381629 GSN 1 GO:0046599 regulation of centriole replication 1/852 21/18722 0.624174612316037 0.757528532381629 PLK2 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/852 21/18722 0.624174612316037 0.757528532381629 EBI3 1 GO:0048745 smooth muscle tissue development 1/852 21/18722 0.624174612316037 0.757528532381629 ENG 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/852 21/18722 0.624174612316037 0.757528532381629 ENG 1 GO:0060117 auditory receptor cell development 1/852 21/18722 0.624174612316037 0.757528532381629 SLC4A7 1 GO:0071498 cellular response to fluid shear stress 1/852 21/18722 0.624174612316037 0.757528532381629 PTK2B 1 GO:0072170 metanephric tubule development 1/852 21/18722 0.624174612316037 0.757528532381629 WWTR1 1 GO:0099500 vesicle fusion to plasma membrane 1/852 21/18722 0.624174612316037 0.757528532381629 SNAP23 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/852 21/18722 0.624174612316037 0.757528532381629 TMEM14A 1 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1/852 21/18722 0.624174612316037 0.757528532381629 MIF 1 GO:1903429 regulation of cell maturation 1/852 21/18722 0.624174612316037 0.757528532381629 EDNRB 1 GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 1/852 21/18722 0.624174612316037 0.757528532381629 RALBP1 1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 1/852 21/18722 0.624174612316037 0.757528532381629 ADAM19 1 GO:0002042 cell migration involved in sprouting angiogenesis 4/852 94/18722 0.624800958392063 0.757959447794313 ITGB1/GATA2/PLK2/HDAC5 4 GO:0007019 microtubule depolymerization 2/852 46/18722 0.625583855779371 0.757959447794313 ARHGEF2/CCSAP 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/852 46/18722 0.625583855779371 0.757959447794313 PVR/CD164 2 GO:0031018 endocrine pancreas development 2/852 46/18722 0.625583855779371 0.757959447794313 SOX4/RHEB 2 GO:0042398 cellular modified amino acid biosynthetic process 2/852 46/18722 0.625583855779371 0.757959447794313 PLOD3/PLOD2 2 GO:0070828 heterochromatin organization 2/852 46/18722 0.625583855779371 0.757959447794313 MBD2/MBD3 2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 2/852 46/18722 0.625583855779371 0.757959447794313 ADAMTS1/ADAM17 2 GO:0001906 cell killing 8/852 188/18722 0.627205931113914 0.759741865534616 HLA-G/DNASE1L3/PVR/CD59/LAMP1/ARL8B/AP1G1/CTSH 8 GO:0016570 histone modification 20/852 463/18722 0.627619569577617 0.759982929525906 IGF2/GATA3/GATA2/SMYD3/TET3/MORF4L2/PKN1/TAF5L/CTNNB1/HDAC5/CARM1/NCOA1/PINK1/JADE1/MAPK3/TP53/DDB1/FMR1/UBE2A/MBD3 20 GO:0051282 regulation of sequestering of calcium ion 5/852 118/18722 0.627706941792011 0.759982929525906 PTK2B/UBASH3B/ITPR2/ERO1A/SRI 5 GO:0032635 interleukin-6 production 7/852 165/18722 0.628763238807433 0.760895739581103 IL1RAP/LPL/XBP1/TNFAIP3/ARHGEF2/GBA/CAPN2 7 GO:0032675 regulation of interleukin-6 production 7/852 165/18722 0.628763238807433 0.760895739581103 IL1RAP/LPL/XBP1/TNFAIP3/ARHGEF2/GBA/CAPN2 7 GO:0051236 establishment of RNA localization 7/852 166/18722 0.635069441371769 0.768342427505797 IGF2BP2/ZFP36L1/XPOT/ZC3H11A/FMR1/MYO1C/IGF2BP3 7 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 2/852 47/18722 0.637311028592987 0.769057494009374 TPM1/CTSZ 2 GO:0016574 histone ubiquitination 2/852 47/18722 0.637311028592987 0.769057494009374 DDB1/UBE2A 2 GO:0032008 positive regulation of TOR signaling 2/852 47/18722 0.637311028592987 0.769057494009374 RHEB/GOLPH3 2 GO:0045581 negative regulation of T cell differentiation 2/852 47/18722 0.637311028592987 0.769057494009374 ERBB2/MDK 2 GO:0090279 regulation of calcium ion import 2/852 47/18722 0.637311028592987 0.769057494009374 CTNNB1/LGALS3 2 GO:0097028 dendritic cell differentiation 2/852 47/18722 0.637311028592987 0.769057494009374 HLA-G/NOTCH2 2 GO:0001505 regulation of neurotransmitter levels 9/852 213/18722 0.637467497353947 0.769057494009374 ITGB1/SYT8/SLC6A2/MAOA/STXBP5/SNAP23/CTBP2/SLC1A3/FMR1 9 GO:0070555 response to interleukin-1 6/852 143/18722 0.638008072776727 0.769057494009374 IL1R1/TFPI/SFRP1/IL1R2/EGR1/MAPK3 6 GO:0006907 pinocytosis 1/852 22/18722 0.641296864083683 0.769057494009374 DNM2 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/852 22/18722 0.641296864083683 0.769057494009374 CD9 1 GO:0009190 cyclic nucleotide biosynthetic process 1/852 22/18722 0.641296864083683 0.769057494009374 ADCY7 1 GO:0009220 pyrimidine ribonucleotide biosynthetic process 1/852 22/18722 0.641296864083683 0.769057494009374 CMPK1 1 GO:0010310 regulation of hydrogen peroxide metabolic process 1/852 22/18722 0.641296864083683 0.769057494009374 PINK1 1 GO:0014821 phasic smooth muscle contraction 1/852 22/18722 0.641296864083683 0.769057494009374 EDNRB 1 GO:0021854 hypothalamus development 1/852 22/18722 0.641296864083683 0.769057494009374 NCOA1 1 GO:0032069 regulation of nuclease activity 1/852 22/18722 0.641296864083683 0.769057494009374 TMBIM6 1 GO:0033617 mitochondrial cytochrome c oxidase assembly 1/852 22/18722 0.641296864083683 0.769057494009374 PET100 1 GO:0034755 iron ion transmembrane transport 1/852 22/18722 0.641296864083683 0.769057494009374 SLC39A8 1 GO:0035024 negative regulation of Rho protein signal transduction 1/852 22/18722 0.641296864083683 0.769057494009374 ITGB1 1 GO:0035089 establishment of apical/basal cell polarity 1/852 22/18722 0.641296864083683 0.769057494009374 FAT1 1 GO:0043574 peroxisomal transport 1/852 22/18722 0.641296864083683 0.769057494009374 RAB8B 1 GO:0045061 thymic T cell selection 1/852 22/18722 0.641296864083683 0.769057494009374 GATA3 1 GO:0045540 regulation of cholesterol biosynthetic process 1/852 22/18722 0.641296864083683 0.769057494009374 APOE 1 GO:0045663 positive regulation of myoblast differentiation 1/852 22/18722 0.641296864083683 0.769057494009374 IGFBP3 1 GO:0046058 cAMP metabolic process 1/852 22/18722 0.641296864083683 0.769057494009374 ADCY7 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/852 22/18722 0.641296864083683 0.769057494009374 IGF2 1 GO:0052652 cyclic purine nucleotide metabolic process 1/852 22/18722 0.641296864083683 0.769057494009374 ADCY7 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/852 22/18722 0.641296864083683 0.769057494009374 KCNJ2 1 GO:0090280 positive regulation of calcium ion import 1/852 22/18722 0.641296864083683 0.769057494009374 LGALS3 1 GO:0099563 modification of synaptic structure 1/852 22/18722 0.641296864083683 0.769057494009374 TIAM1 1 GO:0106118 regulation of sterol biosynthetic process 1/852 22/18722 0.641296864083683 0.769057494009374 APOE 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/852 22/18722 0.641296864083683 0.769057494009374 GATA2 1 GO:2000725 regulation of cardiac muscle cell differentiation 1/852 22/18722 0.641296864083683 0.769057494009374 TGFB1 1 GO:2000773 negative regulation of cellular senescence 1/852 22/18722 0.641296864083683 0.769057494009374 PLK2 1 GO:0006637 acyl-CoA metabolic process 4/852 96/18722 0.641311687152188 0.769057494009374 PIPOX/TECR/ACSL4/ACSL3 4 GO:0035383 thioester metabolic process 4/852 96/18722 0.641311687152188 0.769057494009374 PIPOX/TECR/ACSL4/ACSL3 4 GO:0007254 JNK cascade 7/852 167/18722 0.641314186838336 0.769057494009374 SFRP1/SMAD3/PTK2B/CDC42EP5/PINK1/HIPK3/SH2D3A 7 GO:0001736 establishment of planar polarity 3/852 72/18722 0.642366968073474 0.769339491317251 SFRP1/GPC4/TIAM1 3 GO:0007164 establishment of tissue polarity 3/852 72/18722 0.642366968073474 0.769339491317251 SFRP1/GPC4/TIAM1 3 GO:0035567 non-canonical Wnt signaling pathway 3/852 72/18722 0.642366968073474 0.769339491317251 SFRP1/GPC4/TIAM1 3 GO:0055021 regulation of cardiac muscle tissue growth 3/852 72/18722 0.642366968073474 0.769339491317251 NOG/CITED2/TGFBR3 3 GO:0006304 DNA modification 5/852 120/18722 0.642466497517664 0.769339491317251 GATA3/TET3/GRHL2/MBD2/MBD3 5 GO:0072655 establishment of protein localization to mitochondrion 5/852 120/18722 0.642466497517664 0.769339491317251 TSPO/RHOU/LMAN1/PINK1/SH3GLB1 5 GO:0006091 generation of precursor metabolites and energy 21/852 490/18722 0.643559313827803 0.770464801735331 IGF2/IL6ST/PRKAG2/POMC/P4HA2/PHKG1/GAA/PDIA5/INSR/DHRS3/GFPT1/H6PD/GBA/ACOX1/PINK1/OPN3/PPP1CB/PYGL/TP53/IFNAR1/UQCR11 21 GO:0010324 membrane invagination 6/852 144/18722 0.644697161857126 0.771643475773345 GATA2/ABCA7/ABCA1/MYH9/GULP1/GSN 6 GO:0006520 cellular amino acid metabolic process 12/852 284/18722 0.645230210760806 0.772097872267983 PLOD3/PLOD2/PIPOX/PYCR1/SLC39A8/GFPT1/GLS/RARS2/SERINC3/SLC1A3/BCAT1/ATF4 12 GO:0002833 positive regulation of response to biotic stimulus 7/852 168/18722 0.647496669954521 0.774625799829119 HLA-G/PVR/GRN/SASH1/LAMP1/AP1G1/UBE2K 7 GO:0002686 negative regulation of leukocyte migration 2/852 48/18722 0.648747769415904 0.775385305977261 MIF/DPP4 2 GO:0006111 regulation of gluconeogenesis 2/852 48/18722 0.648747769415904 0.775385305977261 FAM3C/DDB1 2 GO:0090311 regulation of protein deacetylation 2/852 48/18722 0.648747769415904 0.775385305977261 PINK1/TP53 2 GO:1905710 positive regulation of membrane permeability 2/852 48/18722 0.648747769415904 0.775385305977261 TMEM14A/TP53 2 GO:0044772 mitotic cell cycle phase transition 18/852 424/18722 0.653415539468343 0.778983689688839 ITGB1/ADAMTS1/SOX4/RPS27L/CCNG2/EIF4EBP1/PLK2/DNM2/ZFP36L1/JADE1/CTDSP1/PPP3CA/TP53/DDB1/BCAT1/WEE1/ADAM17/CCNE1 18 GO:0009152 purine ribonucleotide biosynthetic process 7/852 169/18722 0.653616138289445 0.778983689688839 PRKAG2/TGFB1/TECR/ADCY7/PINK1/ACSL4/ACSL3 7 GO:0031109 microtubule polymerization or depolymerization 5/852 122/18722 0.656855932105322 0.778983689688839 MAPRE2/MAP7D3/ARHGEF2/CCSAP/ARHGEF7 5 GO:0001759 organ induction 1/852 23/18722 0.657639916051634 0.778983689688839 CTNNB1 1 GO:0002052 positive regulation of neuroblast proliferation 1/852 23/18722 0.657639916051634 0.778983689688839 CTNNB1 1 GO:0002082 regulation of oxidative phosphorylation 1/852 23/18722 0.657639916051634 0.778983689688839 PINK1 1 GO:0002363 alpha-beta T cell lineage commitment 1/852 23/18722 0.657639916051634 0.778983689688839 CTSL 1 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 1/852 23/18722 0.657639916051634 0.778983689688839 CTSZ 1 GO:0003323 type B pancreatic cell development 1/852 23/18722 0.657639916051634 0.778983689688839 RHEB 1 GO:0007130 synaptonemal complex assembly 1/852 23/18722 0.657639916051634 0.778983689688839 P3H4 1 GO:0010888 negative regulation of lipid storage 1/852 23/18722 0.657639916051634 0.778983689688839 ABCA1 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/852 23/18722 0.657639916051634 0.778983689688839 CLDN19 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/852 23/18722 0.657639916051634 0.778983689688839 ZC3H11A 1 GO:0019430 removal of superoxide radicals 1/852 23/18722 0.657639916051634 0.778983689688839 SOD3 1 GO:0030194 positive regulation of blood coagulation 1/852 23/18722 0.657639916051634 0.778983689688839 SERPINE1 1 GO:0030539 male genitalia development 1/852 23/18722 0.657639916051634 0.778983689688839 CTNNB1 1 GO:0031280 negative regulation of cyclase activity 1/852 23/18722 0.657639916051634 0.778983689688839 EDNRB 1 GO:0032740 positive regulation of interleukin-17 production 1/852 23/18722 0.657639916051634 0.778983689688839 TGFB1 1 GO:0034105 positive regulation of tissue remodeling 1/852 23/18722 0.657639916051634 0.778983689688839 PPP3CA 1 GO:0035812 renal sodium excretion 1/852 23/18722 0.657639916051634 0.778983689688839 EDNRB 1 GO:0035929 steroid hormone secretion 1/852 23/18722 0.657639916051634 0.778983689688839 POMC 1 GO:0040019 positive regulation of embryonic development 1/852 23/18722 0.657639916051634 0.778983689688839 B4GALT5 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/852 23/18722 0.657639916051634 0.778983689688839 CTSL 1 GO:0046618 xenobiotic export 1/852 23/18722 0.657639916051634 0.778983689688839 RALBP1 1 GO:0050765 negative regulation of phagocytosis 1/852 23/18722 0.657639916051634 0.778983689688839 CNN2 1 GO:0051590 positive regulation of neurotransmitter transport 1/852 23/18722 0.657639916051634 0.778983689688839 ITGB1 1 GO:0051882 mitochondrial depolarization 1/852 23/18722 0.657639916051634 0.778983689688839 TSPO 1 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 1/852 23/18722 0.657639916051634 0.778983689688839 GJA5 1 GO:0060384 innervation 1/852 23/18722 0.657639916051634 0.778983689688839 SERPINE2 1 GO:0060487 lung epithelial cell differentiation 1/852 23/18722 0.657639916051634 0.778983689688839 GRHL2 1 GO:0060547 negative regulation of necrotic cell death 1/852 23/18722 0.657639916051634 0.778983689688839 ARHGEF2 1 GO:0071218 cellular response to misfolded protein 1/852 23/18722 0.657639916051634 0.778983689688839 SDF2L1 1 GO:0071514 genetic imprinting 1/852 23/18722 0.657639916051634 0.778983689688839 IGF2 1 GO:0072677 eosinophil migration 1/852 23/18722 0.657639916051634 0.778983689688839 LGALS3 1 GO:0090335 regulation of brown fat cell differentiation 1/852 23/18722 0.657639916051634 0.778983689688839 RREB1 1 GO:1900048 positive regulation of hemostasis 1/852 23/18722 0.657639916051634 0.778983689688839 SERPINE1 1 GO:1903306 negative regulation of regulated secretory pathway 1/852 23/18722 0.657639916051634 0.778983689688839 FMR1 1 GO:2001169 regulation of ATP biosynthetic process 1/852 23/18722 0.657639916051634 0.778983689688839 PINK1 1 GO:0007259 receptor signaling pathway via JAK-STAT 7/852 170/18722 0.659671891398494 0.77963792053785 IL6ST/CSH1/PTK2B/CSF1R/STAT2/JAK1/IFNAR1 7 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 2/852 49/18722 0.659896193421665 0.77963792053785 TGFB1/NDFIP1 2 GO:0002208 somatic diversification of immunoglobulins involved in immune response 2/852 49/18722 0.659896193421665 0.77963792053785 TGFB1/NDFIP1 2 GO:0006778 porphyrin-containing compound metabolic process 2/852 49/18722 0.659896193421665 0.77963792053785 TSPO/PGRMC1 2 GO:0007602 phototransduction 2/852 49/18722 0.659896193421665 0.77963792053785 OPN3/GNAQ 2 GO:0009994 oocyte differentiation 2/852 49/18722 0.659896193421665 0.77963792053785 PTK2B/CTNNB1 2 GO:0018198 peptidyl-cysteine modification 2/852 49/18722 0.659896193421665 0.77963792053785 ZDHHC9/TXN 2 GO:0021515 cell differentiation in spinal cord 2/852 49/18722 0.659896193421665 0.77963792053785 GATA2/SOX4 2 GO:0045190 isotype switching 2/852 49/18722 0.659896193421665 0.77963792053785 TGFB1/NDFIP1 2 GO:0051932 synaptic transmission, GABAergic 2/852 49/18722 0.659896193421665 0.77963792053785 PLCL2/TPBG 2 GO:1990573 potassium ion import across plasma membrane 2/852 49/18722 0.659896193421665 0.77963792053785 SLC12A8/KCNJ2 2 GO:0009201 ribonucleoside triphosphate biosynthetic process 3/852 74/18722 0.660715036189796 0.780239037340038 PRKAG2/TGFB1/PINK1 3 GO:0051881 regulation of mitochondrial membrane potential 3/852 74/18722 0.660715036189796 0.780239037340038 TSPO/PYCR1/PINK1 3 GO:0006813 potassium ion transport 10/852 241/18722 0.662349473442608 0.781985667332077 ITGB1/SLC12A8/KCNK12/PTK2B/KCNJ2/FLNA/CD63/DNM2/GJA5/SLC1A3 10 GO:0000045 autophagosome assembly 4/852 99/18722 0.665170038149598 0.78513152017048 WIPI1/PINK1/SEC22B/SH3GLB1 4 GO:0006278 RNA-dependent DNA biosynthetic process 3/852 75/18722 0.66962997116584 0.788553138153851 TNKS2/CTNNB1/MAPK3 3 GO:0008088 axo-dendritic transport 3/852 75/18722 0.66962997116584 0.788553138153851 HSPB1/AP3S1/ARL8B 3 GO:0034121 regulation of toll-like receptor signaling pathway 3/852 75/18722 0.66962997116584 0.788553138153851 PTPRS/TNFAIP3/RTN4 3 GO:0045913 positive regulation of carbohydrate metabolic process 3/852 75/18722 0.66962997116584 0.788553138153851 IGF2/INSR/DDB1 3 GO:1902369 negative regulation of RNA catabolic process 3/852 75/18722 0.66962997116584 0.788553138153851 PABPC1/FMR1/PKP3 3 GO:2001259 positive regulation of cation channel activity 3/852 75/18722 0.66962997116584 0.788553138153851 EPHB2/IFNGR2/PINK1 3 GO:0045058 T cell selection 2/852 50/18722 0.670758824506297 0.788553138153851 GATA3/CTSL 2 GO:0045814 negative regulation of gene expression, epigenetic 2/852 50/18722 0.670758824506297 0.788553138153851 MBD2/MBD3 2 GO:0099054 presynapse assembly 2/852 50/18722 0.670758824506297 0.788553138153851 IL1RAP/GPC4 2 GO:0042770 signal transduction in response to DNA damage 7/852 172/18722 0.67158970487278 0.788553138153851 SOX4/RPS27L/PLK2/NDRG1/MIF/MYO6/TP53 7 GO:0043543 protein acylation 10/852 243/18722 0.672400854581139 0.788553138153851 GATA3/GATA2/ZDHHC9/SOX4/MORF4L2/TAF5L/NCOA1/JADE1/MAPK3/MBD3 10 GO:0060079 excitatory postsynaptic potential 4/852 100/18722 0.672877653926648 0.788553138153851 PTK2B/SH3GL1/PPP3CA/P2RX4 4 GO:0001783 B cell apoptotic process 1/852 24/18722 0.673239188286727 0.788553138153851 PKN1 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/852 24/18722 0.673239188286727 0.788553138153851 HLA-G 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/852 24/18722 0.673239188286727 0.788553138153851 GATA3 1 GO:0010155 regulation of proton transport 1/852 24/18722 0.673239188286727 0.788553138153851 ACTN4 1 GO:0010288 response to lead ion 1/852 24/18722 0.673239188286727 0.788553138153851 SPARC 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/852 24/18722 0.673239188286727 0.788553138153851 ZDHHC9 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/852 24/18722 0.673239188286727 0.788553138153851 ZDHHC9 1 GO:0030859 polarized epithelial cell differentiation 1/852 24/18722 0.673239188286727 0.788553138153851 FAT1 1 GO:0032928 regulation of superoxide anion generation 1/852 24/18722 0.673239188286727 0.788553138153851 TGFB1 1 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/852 24/18722 0.673239188286727 0.788553138153851 SEC14L1 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/852 24/18722 0.673239188286727 0.788553138153851 IGFBP3 1 GO:0044062 regulation of excretion 1/852 24/18722 0.673239188286727 0.788553138153851 EDNRB 1 GO:0050820 positive regulation of coagulation 1/852 24/18722 0.673239188286727 0.788553138153851 SERPINE1 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/852 24/18722 0.673239188286727 0.788553138153851 TP53 1 GO:0051647 nucleus localization 1/852 24/18722 0.673239188286727 0.788553138153851 SUN2 1 GO:0051923 sulfation 1/852 24/18722 0.673239188286727 0.788553138153851 EXT2 1 GO:0060561 apoptotic process involved in morphogenesis 1/852 24/18722 0.673239188286727 0.788553138153851 TGFB2 1 GO:0061162 establishment of monopolar cell polarity 1/852 24/18722 0.673239188286727 0.788553138153851 FAT1 1 GO:0090023 positive regulation of neutrophil chemotaxis 1/852 24/18722 0.673239188286727 0.788553138153851 MDK 1 GO:1903861 positive regulation of dendrite extension 1/852 24/18722 0.673239188286727 0.788553138153851 SLC23A2 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/852 24/18722 0.673239188286727 0.788553138153851 HLA-G 1 GO:0031503 protein-containing complex localization 9/852 220/18722 0.675111617842075 0.790562301675003 GPC4/HIP1/ADAM10/TNFAIP2/DAG1/NPTN/XPOT/EZR/ZC3H11A 9 GO:0009123 nucleoside monophosphate metabolic process 3/852 76/18722 0.678372132454241 0.794195613547847 TJP2/RFK/CMPK1 3 GO:0018105 peptidyl-serine phosphorylation 13/852 315/18722 0.680655729018643 0.796683787011821 PLCL2/TGFB1/SMYD3/PKN1/PLK2/PINK1/TXN/MIF/MAPK3/BCAR3/CSNK1A1/HIPK3/SH2D3A 13 GO:0009584 detection of visible light 2/852 51/18722 0.68133855379594 0.796927014003013 OPN3/GNAQ 2 GO:0010656 negative regulation of muscle cell apoptotic process 2/852 51/18722 0.68133855379594 0.796927014003013 PTK2B/MDK 2 GO:0060632 regulation of microtubule-based movement 2/852 51/18722 0.68133855379594 0.796927014003013 LAMP1/CCSAP 2 GO:0032874 positive regulation of stress-activated MAPK cascade 5/852 126/18722 0.684499123644509 0.80021966338478 TGFB2/PTK2B/SEMA4C/SASH1/EMC10 5 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 1/852 25/18722 0.688128492574871 0.80021966338478 GJA5 1 GO:0010842 retina layer formation 1/852 25/18722 0.688128492574871 0.80021966338478 OBSL1 1 GO:0030318 melanocyte differentiation 1/852 25/18722 0.688128492574871 0.80021966338478 EDNRB 1 GO:0032104 regulation of response to extracellular stimulus 1/852 25/18722 0.688128492574871 0.80021966338478 NUCB2 1 GO:0032107 regulation of response to nutrient levels 1/852 25/18722 0.688128492574871 0.80021966338478 NUCB2 1 GO:0032925 regulation of activin receptor signaling pathway 1/852 25/18722 0.688128492574871 0.80021966338478 FSTL3 1 GO:0035902 response to immobilization stress 1/852 25/18722 0.688128492574871 0.80021966338478 PTK2B 1 GO:0045109 intermediate filament organization 1/852 25/18722 0.688128492574871 0.80021966338478 PKP2 1 GO:0045324 late endosome to vacuole transport 1/852 25/18722 0.688128492574871 0.80021966338478 TMEM50A 1 GO:0045822 negative regulation of heart contraction 1/852 25/18722 0.688128492574871 0.80021966338478 SRI 1 GO:0046339 diacylglycerol metabolic process 1/852 25/18722 0.688128492574871 0.80021966338478 DGKZ 1 GO:0048596 embryonic camera-type eye morphogenesis 1/852 25/18722 0.688128492574871 0.80021966338478 CITED2 1 GO:0051291 protein heterooligomerization 1/852 25/18722 0.688128492574871 0.80021966338478 KRT10 1 GO:0051788 response to misfolded protein 1/852 25/18722 0.688128492574871 0.80021966338478 SDF2L1 1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 1/852 25/18722 0.688128492574871 0.80021966338478 TP53 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/852 25/18722 0.688128492574871 0.80021966338478 FAT1 1 GO:0071450 cellular response to oxygen radical 1/852 25/18722 0.688128492574871 0.80021966338478 SOD3 1 GO:0071451 cellular response to superoxide 1/852 25/18722 0.688128492574871 0.80021966338478 SOD3 1 GO:0090169 regulation of spindle assembly 1/852 25/18722 0.688128492574871 0.80021966338478 CCSAP 1 GO:0090382 phagosome maturation 1/852 25/18722 0.688128492574871 0.80021966338478 ARL8B 1 GO:0098581 detection of external biotic stimulus 1/852 25/18722 0.688128492574871 0.80021966338478 SCARB1 1 GO:1903959 regulation of anion transmembrane transport 1/852 25/18722 0.688128492574871 0.80021966338478 ITGB1 1 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 1/852 25/18722 0.688128492574871 0.80021966338478 TPM1 1 GO:1905563 negative regulation of vascular endothelial cell proliferation 1/852 25/18722 0.688128492574871 0.80021966338478 FLT1 1 GO:0007129 homologous chromosome pairing at meiosis 2/852 52/18722 0.691638601076972 0.803930041390393 P3H4/CCNE1 2 GO:0043392 negative regulation of DNA binding 2/852 52/18722 0.691638601076972 0.803930041390393 ID1/SRI 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 3/852 78/18722 0.695339281743536 0.807990694861119 GATA2/PLK2/HDAC5 3 GO:0050871 positive regulation of B cell activation 6/852 152/18722 0.695453147255785 0.807990694861119 TGFB1/EPHB2/XBP1/MMP14/CD320/MIF 6 GO:0006403 RNA localization 8/852 201/18722 0.70002812602858 0.809602904244496 MEX3D/IGF2BP2/ZFP36L1/XPOT/ZC3H11A/FMR1/MYO1C/IGF2BP3 8 GO:0001541 ovarian follicle development 2/852 53/18722 0.701662478969046 0.809602904244496 INHA/MMP14 2 GO:0002707 negative regulation of lymphocyte mediated immunity 2/852 53/18722 0.701662478969046 0.809602904244496 HLA-G/NDFIP1 2 GO:0016925 protein sumoylation 2/852 53/18722 0.701662478969046 0.809602904244496 CTNNB1/EGR1 2 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/852 53/18722 0.701662478969046 0.809602904244496 ADM/DNM2 2 GO:0099172 presynapse organization 2/852 53/18722 0.701662478969046 0.809602904244496 IL1RAP/GPC4 2 GO:0140694 non-membrane-bounded organelle assembly 15/852 367/18722 0.702231890992754 0.809602904244496 TPM1/ITGB1/KRT19/SH3PXD2B/MAPRE2/KRT8/FLNA/RPS27L/PLK2/CCDC69/CCSAP/EZR/GSN/CSRP1/OBSL1 15 GO:0001556 oocyte maturation 1/852 26/18722 0.702340105364421 0.809602904244496 PTK2B 1 GO:0002710 negative regulation of T cell mediated immunity 1/852 26/18722 0.702340105364421 0.809602904244496 HLA-G 1 GO:0003416 endochondral bone growth 1/852 26/18722 0.702340105364421 0.809602904244496 COL27A1 1 GO:0006760 folic acid-containing compound metabolic process 1/852 26/18722 0.702340105364421 0.809602904244496 PIPOX 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/852 26/18722 0.702340105364421 0.809602904244496 PLCL2 1 GO:0008535 respiratory chain complex IV assembly 1/852 26/18722 0.702340105364421 0.809602904244496 PET100 1 GO:0034114 regulation of heterotypic cell-cell adhesion 1/852 26/18722 0.702340105364421 0.809602904244496 MYADM 1 GO:0042278 purine nucleoside metabolic process 1/852 26/18722 0.702340105364421 0.809602904244496 AMD1 1 GO:0042634 regulation of hair cycle 1/852 26/18722 0.702340105364421 0.809602904244496 TGFB2 1 GO:0043501 skeletal muscle adaptation 1/852 26/18722 0.702340105364421 0.809602904244496 PPP3CA 1 GO:0045026 plasma membrane fusion 1/852 26/18722 0.702340105364421 0.809602904244496 CD9 1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 1/852 26/18722 0.702340105364421 0.809602904244496 CMTM3 1 GO:0051350 negative regulation of lyase activity 1/852 26/18722 0.702340105364421 0.809602904244496 EDNRB 1 GO:0060295 regulation of cilium movement involved in cell motility 1/852 26/18722 0.702340105364421 0.809602904244496 CCSAP 1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 1/852 26/18722 0.702340105364421 0.809602904244496 SRI 1 GO:0060352 cell adhesion molecule production 1/852 26/18722 0.702340105364421 0.809602904244496 GOLPH3 1 GO:0060544 regulation of necroptotic process 1/852 26/18722 0.702340105364421 0.809602904244496 ARHGEF2 1 GO:0070193 synaptonemal complex organization 1/852 26/18722 0.702340105364421 0.809602904244496 P3H4 1 GO:0071425 hematopoietic stem cell proliferation 1/852 26/18722 0.702340105364421 0.809602904244496 GBA 1 GO:0072273 metanephric nephron morphogenesis 1/852 26/18722 0.702340105364421 0.809602904244496 CTNNB1 1 GO:0099637 neurotransmitter receptor transport 1/852 26/18722 0.702340105364421 0.809602904244496 HIP1 1 GO:1901071 glucosamine-containing compound metabolic process 1/852 26/18722 0.702340105364421 0.809602904244496 PGM3 1 GO:1902019 regulation of cilium-dependent cell motility 1/852 26/18722 0.702340105364421 0.809602904244496 CCSAP 1 GO:1903523 negative regulation of blood circulation 1/852 26/18722 0.702340105364421 0.809602904244496 SRI 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/852 26/18722 0.702340105364421 0.809602904244496 ENG 1 GO:0032006 regulation of TOR signaling 4/852 104/18722 0.702470868832846 0.809602904244496 SH3BP4/GBA/RHEB/GOLPH3 4 GO:0046634 regulation of alpha-beta T cell activation 4/852 104/18722 0.702470868832846 0.809602904244496 EBI3/GATA3/CBLB/HSPH1 4 GO:0048661 positive regulation of smooth muscle cell proliferation 4/852 104/18722 0.702470868832846 0.809602904244496 HPGD/ADAMTS1/MMP2/TGFB1 4 GO:0051279 regulation of release of sequestered calcium ion into cytosol 3/852 79/18722 0.703565328761447 0.810493087584427 PTK2B/UBASH3B/SRI 3 GO:0060420 regulation of heart growth 3/852 79/18722 0.703565328761447 0.810493087584427 NOG/CITED2/TGFBR3 3 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/852 54/18722 0.711413959671752 0.818972200143625 HLA-G/NDFIP1 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/852 54/18722 0.711413959671752 0.818972200143625 P2RX4/SRI 2 GO:2000300 regulation of synaptic vesicle exocytosis 2/852 54/18722 0.711413959671752 0.818972200143625 STXBP5/FMR1 2 GO:0032204 regulation of telomere maintenance 3/852 80/18722 0.711620695923593 0.819022859040349 TNKS2/CTNNB1/MAPK3 3 GO:0010970 transport along microtubule 6/852 155/18722 0.713187818764864 0.819083665982963 HSPB1/AP3S1/LAMP1/SUN2/COPG1/ARL8B 6 GO:0002227 innate immune response in mucosa 1/852 27/18722 0.715904837404938 0.819083665982963 RPL39 1 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1/852 27/18722 0.715904837404938 0.819083665982963 PTK2 1 GO:0002825 regulation of T-helper 1 type immune response 1/852 27/18722 0.715904837404938 0.819083665982963 IL1R1 1 GO:0007026 negative regulation of microtubule depolymerization 1/852 27/18722 0.715904837404938 0.819083665982963 ARHGEF2 1 GO:0007263 nitric oxide mediated signal transduction 1/852 27/18722 0.715904837404938 0.819083665982963 APOE 1 GO:0008053 mitochondrial fusion 1/852 27/18722 0.715904837404938 0.819083665982963 VAT1 1 GO:0031954 positive regulation of protein autophosphorylation 1/852 27/18722 0.715904837404938 0.819083665982963 IQGAP1 1 GO:0032786 positive regulation of DNA-templated transcription, elongation 1/852 27/18722 0.715904837404938 0.819083665982963 CTNNB1 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/852 27/18722 0.715904837404938 0.819083665982963 TNFAIP3 1 GO:0034453 microtubule anchoring 1/852 27/18722 0.715904837404938 0.819083665982963 DAG1 1 GO:0035116 embryonic hindlimb morphogenesis 1/852 27/18722 0.715904837404938 0.819083665982963 CTNNB1 1 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 1/852 27/18722 0.715904837404938 0.819083665982963 PTK2 1 GO:0039529 RIG-I signaling pathway 1/852 27/18722 0.715904837404938 0.819083665982963 SEC14L1 1 GO:0042104 positive regulation of activated T cell proliferation 1/852 27/18722 0.715904837404938 0.819083665982963 IGF2 1 GO:0045830 positive regulation of isotype switching 1/852 27/18722 0.715904837404938 0.819083665982963 TGFB1 1 GO:0046174 polyol catabolic process 1/852 27/18722 0.715904837404938 0.819083665982963 IMPA2 1 GO:0046337 phosphatidylethanolamine metabolic process 1/852 27/18722 0.715904837404938 0.819083665982963 MFSD2A 1 GO:0048873 homeostasis of number of cells within a tissue 1/852 27/18722 0.715904837404938 0.819083665982963 GATA2 1 GO:0071624 positive regulation of granulocyte chemotaxis 1/852 27/18722 0.715904837404938 0.819083665982963 MDK 1 GO:0099625 ventricular cardiac muscle cell membrane repolarization 1/852 27/18722 0.715904837404938 0.819083665982963 GJA5 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/852 27/18722 0.715904837404938 0.819083665982963 DNM2 1 GO:1903421 regulation of synaptic vesicle recycling 1/852 27/18722 0.715904837404938 0.819083665982963 SH3GL1 1 GO:1903859 regulation of dendrite extension 1/852 27/18722 0.715904837404938 0.819083665982963 SLC23A2 1 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 1/852 27/18722 0.715904837404938 0.819083665982963 TNKS2 1 GO:2000463 positive regulation of excitatory postsynaptic potential 1/852 27/18722 0.715904837404938 0.819083665982963 PTK2B 1 GO:0009185 ribonucleoside diphosphate metabolic process 4/852 106/18722 0.716523544022844 0.819141440405758 PRKAG2/INSR/TJP2/CMPK1 4 GO:0042116 macrophage activation 4/852 106/18722 0.716523544022844 0.819141440405758 GRN/IFNGR2/LDLR/MIF 4 GO:0099565 chemical synaptic transmission, postsynaptic 4/852 106/18722 0.716523544022844 0.819141440405758 PTK2B/SH3GL1/PPP3CA/P2RX4 4 GO:0015698 inorganic anion transport 7/852 180/18722 0.716606350507958 0.819141440405758 SLC4A7/TSPO/SLC12A8/SLC39A8/CLIC4/PCYOX1/SLC1A3 7 GO:0045089 positive regulation of innate immune response 5/852 131/18722 0.71688302713006 0.819271633865939 HLA-G/PVR/LAMP1/AP1G1/UBE2K 5 GO:0046631 alpha-beta T cell activation 6/852 156/18722 0.718939258337764 0.821337135431329 EBI3/GATA3/CTSL/ELF4/CBLB/HSPH1 6 GO:0001942 hair follicle development 3/852 81/18722 0.719506344151943 0.821337135431329 TGFB2/CTNNB1/LAMA5 3 GO:0001960 negative regulation of cytokine-mediated signaling pathway 3/852 81/18722 0.719506344151943 0.821337135431329 IL1R2/ISG15/STAT2 3 GO:0008589 regulation of smoothened signaling pathway 3/852 81/18722 0.719506344151943 0.821337135431329 SERPINE2/SFRP1/HERC4 3 GO:0010833 telomere maintenance via telomere lengthening 3/852 81/18722 0.719506344151943 0.821337135431329 TNKS2/CTNNB1/MAPK3 3 GO:0008637 apoptotic mitochondrial changes 4/852 107/18722 0.723364300951506 0.825553860927195 TNFSF10/PINK1/TMEM14A/TP53 4 GO:1902600 proton transmembrane transport 6/852 157/18722 0.724610388089349 0.826698198645093 ATP6V0E1/SLC17A5/TMCO3/SLC15A3/ACTN4/ATP6AP1 6 GO:0060401 cytosolic calcium ion transport 7/852 182/18722 0.727183166908487 0.826698198645093 PTK2B/UBASH3B/ITPR2/P2RX4/ERO1A/TMBIM6/SRI 7 GO:0009205 purine ribonucleoside triphosphate metabolic process 3/852 82/18722 0.727223386628465 0.826698198645093 PRKAG2/TGFB1/PINK1 3 GO:2001252 positive regulation of chromosome organization 3/852 82/18722 0.727223386628465 0.826698198645093 TNKS2/CTNNB1/MAPK3 3 GO:0000303 response to superoxide 1/852 28/18722 0.728852100230881 0.826698198645093 SOD3 1 GO:0002675 positive regulation of acute inflammatory response 1/852 28/18722 0.728852100230881 0.826698198645093 IL6ST 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/852 28/18722 0.728852100230881 0.826698198645093 SDF2L1 1 GO:0007141 male meiosis I 1/852 28/18722 0.728852100230881 0.826698198645093 FOXJ3 1 GO:0007271 synaptic transmission, cholinergic 1/852 28/18722 0.728852100230881 0.826698198645093 APOE 1 GO:0008299 isoprenoid biosynthetic process 1/852 28/18722 0.728852100230881 0.826698198645093 RDH10 1 GO:0009065 glutamine family amino acid catabolic process 1/852 28/18722 0.728852100230881 0.826698198645093 GLS 1 GO:0031342 negative regulation of cell killing 1/852 28/18722 0.728852100230881 0.826698198645093 HLA-G 1 GO:0031440 regulation of mRNA 3'-end processing 1/852 28/18722 0.728852100230881 0.826698198645093 ZFP36L1 1 GO:0032438 melanosome organization 1/852 28/18722 0.728852100230881 0.826698198645093 AP1G1 1 GO:0032607 interferon-alpha production 1/852 28/18722 0.728852100230881 0.826698198645093 PTPRS 1 GO:0032647 regulation of interferon-alpha production 1/852 28/18722 0.728852100230881 0.826698198645093 PTPRS 1 GO:0034123 positive regulation of toll-like receptor signaling pathway 1/852 28/18722 0.728852100230881 0.826698198645093 RTN4 1 GO:0038094 Fc-gamma receptor signaling pathway 1/852 28/18722 0.728852100230881 0.826698198645093 PTK2 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/852 28/18722 0.728852100230881 0.826698198645093 ADAM19 1 GO:1903779 regulation of cardiac conduction 1/852 28/18722 0.728852100230881 0.826698198645093 GJA5 1 GO:1990776 response to angiotensin 1/852 28/18722 0.728852100230881 0.826698198645093 IQGAP1 1 GO:0006997 nucleus organization 5/852 133/18722 0.72915573624997 0.826698198645093 SYNE1/RTN4/SUN2/REEP3/CTDNEP1 5 GO:0034440 lipid oxidation 4/852 108/18722 0.730081769769878 0.826698198645093 PRKAG2/PLA2G7/MFSD2A/ACOX1 4 GO:0098659 inorganic cation import across plasma membrane 4/852 108/18722 0.730081769769878 0.826698198645093 SLC39A6/SLC12A8/SLC39A8/KCNJ2 4 GO:0099587 inorganic ion import across plasma membrane 4/852 108/18722 0.730081769769878 0.826698198645093 SLC39A6/SLC12A8/SLC39A8/KCNJ2 4 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/852 56/18722 0.730115933434818 0.826698198645093 PABPC1/ZFP36L1 2 GO:0002886 regulation of myeloid leukocyte mediated immunity 2/852 56/18722 0.730115933434818 0.826698198645093 DNASE1L3/GATA2 2 GO:0015800 acidic amino acid transport 2/852 56/18722 0.730115933434818 0.826698198645093 ITGB1/SLC1A3 2 GO:0032608 interferon-beta production 2/852 56/18722 0.730115933434818 0.826698198645093 PTPRS/ISG15 2 GO:0032648 regulation of interferon-beta production 2/852 56/18722 0.730115933434818 0.826698198645093 PTPRS/ISG15 2 GO:0045071 negative regulation of viral genome replication 2/852 56/18722 0.730115933434818 0.826698198645093 ISG15/BST2 2 GO:0046622 positive regulation of organ growth 2/852 56/18722 0.730115933434818 0.826698198645093 IGF2/TGFBR3 2 GO:0050433 regulation of catecholamine secretion 2/852 56/18722 0.730115933434818 0.826698198645093 SYT8/PINK1 2 GO:1904645 response to amyloid-beta 2/852 56/18722 0.730115933434818 0.826698198645093 MMP2/LRP1 2 GO:1990089 response to nerve growth factor 2/852 56/18722 0.730115933434818 0.826698198645093 PTN/ID1 2 GO:0016447 somatic recombination of immunoglobulin gene segments 2/852 57/18722 0.73907500241638 0.834752691242539 TGFB1/NDFIP1 2 GO:0051785 positive regulation of nuclear division 2/852 57/18722 0.73907500241638 0.834752691242539 IGF2/INSR 2 GO:1902017 regulation of cilium assembly 2/852 57/18722 0.73907500241638 0.834752691242539 DNM2/MAP4 2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 1/852 29/18722 0.741209969633004 0.834752691242539 PABPC1 1 GO:0000305 response to oxygen radical 1/852 29/18722 0.741209969633004 0.834752691242539 SOD3 1 GO:0001773 myeloid dendritic cell activation 1/852 29/18722 0.741209969633004 0.834752691242539 NOTCH2 1 GO:0002068 glandular epithelial cell development 1/852 29/18722 0.741209969633004 0.834752691242539 RHEB 1 GO:0003309 type B pancreatic cell differentiation 1/852 29/18722 0.741209969633004 0.834752691242539 RHEB 1 GO:0006734 NADH metabolic process 1/852 29/18722 0.741209969633004 0.834752691242539 TP53 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/852 29/18722 0.741209969633004 0.834752691242539 CMPK1 1 GO:0010390 histone monoubiquitination 1/852 29/18722 0.741209969633004 0.834752691242539 DDB1 1 GO:0021522 spinal cord motor neuron differentiation 1/852 29/18722 0.741209969633004 0.834752691242539 SOX4 1 GO:0021591 ventricular system development 1/852 29/18722 0.741209969633004 0.834752691242539 C12orf57 1 GO:0032372 negative regulation of sterol transport 1/852 29/18722 0.741209969633004 0.834752691242539 APOC1 1 GO:0032375 negative regulation of cholesterol transport 1/852 29/18722 0.741209969633004 0.834752691242539 APOC1 1 GO:0042759 long-chain fatty acid biosynthetic process 1/852 29/18722 0.741209969633004 0.834752691242539 GPX4 1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1/852 29/18722 0.741209969633004 0.834752691242539 ADAM17 1 GO:0048753 pigment granule organization 1/852 29/18722 0.741209969633004 0.834752691242539 AP1G1 1 GO:0050686 negative regulation of mRNA processing 1/852 29/18722 0.741209969633004 0.834752691242539 SRSF6 1 GO:0070198 protein localization to chromosome, telomeric region 1/852 29/18722 0.741209969633004 0.834752691242539 TNKS2 1 GO:0095500 acetylcholine receptor signaling pathway 1/852 29/18722 0.741209969633004 0.834752691242539 GNAQ 1 GO:0098868 bone growth 1/852 29/18722 0.741209969633004 0.834752691242539 COL27A1 1 GO:1900117 regulation of execution phase of apoptosis 1/852 29/18722 0.741209969633004 0.834752691242539 TP53 1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/852 29/18722 0.741209969633004 0.834752691242539 MIF 1 GO:0006835 dicarboxylic acid transport 3/852 84/18722 0.742156804995779 0.835071584963952 ITGB1/SLC1A5/SLC1A3 3 GO:0022404 molting cycle process 3/852 84/18722 0.742156804995779 0.835071584963952 TGFB2/CTNNB1/LAMA5 3 GO:0022405 hair cycle process 3/852 84/18722 0.742156804995779 0.835071584963952 TGFB2/CTNNB1/LAMA5 3 GO:0061157 mRNA destabilization 3/852 84/18722 0.742156804995779 0.835071584963952 MEX3D/PABPC1/ZFP36L1 3 GO:0007088 regulation of mitotic nuclear division 4/852 110/18722 0.743148707438716 0.836000769901443 IGF2/INSR/CAV2/OBSL1 4 GO:0050432 catecholamine secretion 2/852 58/18722 0.747778775131424 0.840645650041648 SYT8/PINK1 2 GO:1902808 positive regulation of cell cycle G1/S phase transition 2/852 58/18722 0.747778775131424 0.840645650041648 ADAMTS1/ADAM17 2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 2/852 58/18722 0.747778775131424 0.840645650041648 SERINC3/TP53 2 GO:0002440 production of molecular mediator of immune response 12/852 308/18722 0.749356596131555 0.841501513892002 HLA-G/IL1R1/GATA3/TGFB1/TGFB2/EPHB2/XBP1/PKN1/BST2/SEMA7A/NDFIP1/TMBIM6 12 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 3/852 85/18722 0.749376074958068 0.841501513892002 IL6ST/CSH1/CSF1R 3 GO:0055013 cardiac muscle cell development 3/852 85/18722 0.749376074958068 0.841501513892002 PDLIM5/FHL2/OBSL1 3 GO:0097194 execution phase of apoptosis 3/852 85/18722 0.749376074958068 0.841501513892002 DNASE1L3/ENDOG/TP53 3 GO:0098773 skin epidermis development 3/852 85/18722 0.749376074958068 0.841501513892002 TGFB2/CTNNB1/LAMA5 3 GO:0051091 positive regulation of DNA-binding transcription factor activity 10/852 260/18722 0.750433462577043 0.842381730250147 IL1RAP/SMAD3/PLPP3/ARHGEF2/MTDH/CTNNB1/HDAC5/PINK1/PPP3CA/JUP 10 GO:0021953 central nervous system neuron differentiation 6/852 162/18722 0.751760582690906 0.842381730250147 GATA2/EPHB2/SOX4/HERC1/C12orf57/B4GALT5 6 GO:0000132 establishment of mitotic spindle orientation 1/852 30/18722 0.753005246253807 0.842381730250147 ITGB1 1 GO:0006221 pyrimidine nucleotide biosynthetic process 1/852 30/18722 0.753005246253807 0.842381730250147 CMPK1 1 GO:0006884 cell volume homeostasis 1/852 30/18722 0.753005246253807 0.842381730250147 SLC12A8 1 GO:0007202 activation of phospholipase C activity 1/852 30/18722 0.753005246253807 0.842381730250147 GNAQ 1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/852 30/18722 0.753005246253807 0.842381730250147 SRI 1 GO:0019674 NAD metabolic process 1/852 30/18722 0.753005246253807 0.842381730250147 TP53 1 GO:0031365 N-terminal protein amino acid modification 1/852 30/18722 0.753005246253807 0.842381730250147 SOX4 1 GO:0032480 negative regulation of type I interferon production 1/852 30/18722 0.753005246253807 0.842381730250147 PTPRS 1 GO:0036296 response to increased oxygen levels 1/852 30/18722 0.753005246253807 0.842381730250147 ATP6AP1 1 GO:0043304 regulation of mast cell degranulation 1/852 30/18722 0.753005246253807 0.842381730250147 GATA2 1 GO:0045948 positive regulation of translational initiation 1/852 30/18722 0.753005246253807 0.842381730250147 DNAJC3 1 GO:0048799 animal organ maturation 1/852 30/18722 0.753005246253807 0.842381730250147 GATA3 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/852 30/18722 0.753005246253807 0.842381730250147 PTK2B 1 GO:0060603 mammary gland duct morphogenesis 1/852 30/18722 0.753005246253807 0.842381730250147 CSF1R 1 GO:0070229 negative regulation of lymphocyte apoptotic process 1/852 30/18722 0.753005246253807 0.842381730250147 EFNA1 1 GO:0009141 nucleoside triphosphate metabolic process 4/852 112/18722 0.755728954122464 0.845053060675041 PRKAG2/TGFB1/PINK1/CMPK1 4 GO:1901222 regulation of NIK/NF-kappaB signaling 4/852 112/18722 0.755728954122464 0.845053060675041 SASH1/CALR/ACTN4/NFAT5 4 GO:0002820 negative regulation of adaptive immune response 2/852 59/18722 0.756231902283476 0.845427624209847 HLA-G/NDFIP1 2 GO:0060761 negative regulation of response to cytokine stimulus 3/852 86/18722 0.756432508104452 0.845464093557563 IL1R2/ISG15/STAT2 3 GO:0051052 regulation of DNA metabolic process 14/852 359/18722 0.7604557498739 0.849772155665039 GATA3/ACVRL1/TGFB1/PTK2B/ENDOG/TNKS2/BMPR2/GRHL2/CTNNB1/MBD2/MAPK3/TP53/NDFIP1/MBD3 14 GO:0044070 regulation of anion transport 3/852 87/18722 0.763327827690855 0.849795902032623 ITGB1/PTGES/P2RX4 3 GO:0061014 positive regulation of mRNA catabolic process 3/852 87/18722 0.763327827690855 0.849795902032623 MEX3D/PABPC1/ZFP36L1 3 GO:0051783 regulation of nuclear division 5/852 139/18722 0.763648500648004 0.849795902032623 IGF2/INSR/CALR/CAV2/OBSL1 5 GO:0018200 peptidyl-glutamic acid modification 1/852 31/18722 0.764263513437188 0.849795902032623 VKORC1 1 GO:0021988 olfactory lobe development 1/852 31/18722 0.764263513437188 0.849795902032623 SEMA7A 1 GO:0030212 hyaluronan metabolic process 1/852 31/18722 0.764263513437188 0.849795902032623 TGFB1 1 GO:0031114 regulation of microtubule depolymerization 1/852 31/18722 0.764263513437188 0.849795902032623 ARHGEF2 1 GO:0032509 endosome transport via multivesicular body sorting pathway 1/852 31/18722 0.764263513437188 0.849795902032623 TMEM50A 1 GO:0033006 regulation of mast cell activation involved in immune response 1/852 31/18722 0.764263513437188 0.849795902032623 GATA2 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/852 31/18722 0.764263513437188 0.849795902032623 MGAT1 1 GO:0042133 neurotransmitter metabolic process 1/852 31/18722 0.764263513437188 0.849795902032623 MAOA 1 GO:0045987 positive regulation of smooth muscle contraction 1/852 31/18722 0.764263513437188 0.849795902032623 CTTN 1 GO:0048566 embryonic digestive tract development 1/852 31/18722 0.764263513437188 0.849795902032623 TGFB2 1 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1/852 31/18722 0.764263513437188 0.849795902032623 PINK1 1 GO:0060045 positive regulation of cardiac muscle cell proliferation 1/852 31/18722 0.764263513437188 0.849795902032623 TGFBR3 1 GO:0070528 protein kinase C signaling 1/852 31/18722 0.764263513437188 0.849795902032623 MYADM 1 GO:1901797 negative regulation of signal transduction by p53 class mediator 1/852 31/18722 0.764263513437188 0.849795902032623 MIF 1 GO:1905144 response to acetylcholine 1/852 31/18722 0.764263513437188 0.849795902032623 GNAQ 1 GO:1905145 cellular response to acetylcholine 1/852 31/18722 0.764263513437188 0.849795902032623 GNAQ 1 GO:2000144 positive regulation of DNA-templated transcription, initiation 1/852 31/18722 0.764263513437188 0.849795902032623 TP53 1 GO:0002712 regulation of B cell mediated immunity 2/852 60/18722 0.764439140358821 0.849795902032623 TGFB1/NDFIP1 2 GO:0002889 regulation of immunoglobulin mediated immune response 2/852 60/18722 0.764439140358821 0.849795902032623 TGFB1/NDFIP1 2 GO:0006289 nucleotide-excision repair 2/852 60/18722 0.764439140358821 0.849795902032623 TP53/DDB1 2 GO:0070588 calcium ion transmembrane transport 12/852 312/18722 0.764529275661378 0.849795902032623 RRAD/PTK2B/SESTD1/UBASH3B/SEC61A1/ITPR2/P2RX4/ERO1A/AHNAK/FMR1/TMCO1/SRI 12 GO:0002286 T cell activation involved in immune response 4/852 114/18722 0.767828392401485 0.853086158710083 GATA3/LGALS3/TP53/MDK 4 GO:1904892 regulation of receptor signaling pathway via STAT 4/852 114/18722 0.767828392401485 0.853086158710083 MGAT5/CSH1/TGFB1/PTK2B 4 GO:0032886 regulation of microtubule-based process 9/852 240/18722 0.768875819584133 0.853872903787939 ERBB2/MAPRE2/PHLDB2/PLK2/ARHGEF2/LAMP1/CCSAP/ARHGEF7/MACF1 9 GO:0050851 antigen receptor-mediated signaling pathway 9/852 240/18722 0.768875819584133 0.853872903787939 GATA3/PLCL2/CD276/CMTM3/CBLB/PLEKHA1/DGKZ/LGALS3/EZR 9 GO:0007260 tyrosine phosphorylation of STAT protein 3/852 88/18722 0.770063851562601 0.85387340050993 IL6ST/CSH1/CSF1R 3 GO:0009144 purine nucleoside triphosphate metabolic process 3/852 88/18722 0.770063851562601 0.85387340050993 PRKAG2/TGFB1/PINK1 3 GO:0030101 natural killer cell activation 3/852 88/18722 0.770063851562601 0.85387340050993 ELF4/LAMP1/AP1G1 3 GO:0031110 regulation of microtubule polymerization or depolymerization 3/852 88/18722 0.770063851562601 0.85387340050993 MAPRE2/ARHGEF2/ARHGEF7 3 GO:0050779 RNA destabilization 3/852 88/18722 0.770063851562601 0.85387340050993 MEX3D/PABPC1/ZFP36L1 3 GO:0070098 chemokine-mediated signaling pathway 3/852 88/18722 0.770063851562601 0.85387340050993 PTK2B/CCR1/ACKR2 3 GO:1901657 glycosyl compound metabolic process 3/852 88/18722 0.770063851562601 0.85387340050993 GBA/FUCA2/AMD1 3 GO:1905515 non-motile cilium assembly 2/852 61/18722 0.772405332399462 0.856150409489461 DNM2/MAP4 2 GO:0000077 DNA damage checkpoint signaling 4/852 115/18722 0.773699962899448 0.856150409489461 SOX4/RPS27L/PLK2/TP53 4 GO:0034968 histone lysine methylation 4/852 115/18722 0.773699962899448 0.856150409489461 GATA3/SMYD3/TET3/CTNNB1 4 GO:0016571 histone methylation 5/852 141/18722 0.774379519237149 0.856150409489461 GATA3/SMYD3/TET3/CTNNB1/CARM1 5 GO:0003338 metanephros morphogenesis 1/852 32/18722 0.775009192456583 0.856150409489461 CTNNB1 1 GO:0008156 negative regulation of DNA replication 1/852 32/18722 0.775009192456583 0.856150409489461 TP53 1 GO:0009954 proximal/distal pattern formation 1/852 32/18722 0.775009192456583 0.856150409489461 CTNNB1 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/852 32/18722 0.775009192456583 0.856150409489461 MDK 1 GO:0019835 cytolysis 1/852 32/18722 0.775009192456583 0.856150409489461 TGFB1 1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 1/852 32/18722 0.775009192456583 0.856150409489461 CTNNB1 1 GO:0035883 enteroendocrine cell differentiation 1/852 32/18722 0.775009192456583 0.856150409489461 RHEB 1 GO:0042744 hydrogen peroxide catabolic process 1/852 32/18722 0.775009192456583 0.856150409489461 PRDX4 1 GO:0045684 positive regulation of epidermis development 1/852 32/18722 0.775009192456583 0.856150409489461 KRT10 1 GO:0046856 phosphatidylinositol dephosphorylation 1/852 32/18722 0.775009192456583 0.856150409489461 INPPL1 1 GO:0060914 heart formation 1/852 32/18722 0.775009192456583 0.856150409489461 CTNNB1 1 GO:0072337 modified amino acid transport 1/852 32/18722 0.775009192456583 0.856150409489461 SLC6A8 1 GO:0097345 mitochondrial outer membrane permeabilization 1/852 32/18722 0.775009192456583 0.856150409489461 TMEM14A 1 GO:0009199 ribonucleoside triphosphate metabolic process 3/852 89/18722 0.776642483920802 0.857766430013912 PRKAG2/TGFB1/PINK1 3 GO:0097553 calcium ion transmembrane import into cytosol 5/852 142/18722 0.779603410260837 0.860847732304255 PTK2B/UBASH3B/ITPR2/ERO1A/SRI 5 GO:0002260 lymphocyte homeostasis 2/852 62/18722 0.780135390303278 0.860868541854067 TNFAIP3/PKN1 2 GO:0032615 interleukin-12 production 2/852 62/18722 0.780135390303278 0.860868541854067 HLA-G/MDK 2 GO:0032655 regulation of interleukin-12 production 2/852 62/18722 0.780135390303278 0.860868541854067 HLA-G/MDK 2 GO:0071805 potassium ion transmembrane transport 8/852 219/18722 0.784575382382409 0.86331186999656 ITGB1/SLC12A8/KCNK12/KCNJ2/FLNA/CD63/DNM2/SLC1A3 8 GO:0051225 spindle assembly 4/852 117/18722 0.785091680905543 0.86331186999656 MAPRE2/FLNA/CCDC69/CCSAP 4 GO:0001975 response to amphetamine 1/852 33/18722 0.785265595240264 0.86331186999656 PPP3CA 1 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/852 33/18722 0.785265595240264 0.86331186999656 PTK2 1 GO:0006536 glutamate metabolic process 1/852 33/18722 0.785265595240264 0.86331186999656 GLS 1 GO:0018345 protein palmitoylation 1/852 33/18722 0.785265595240264 0.86331186999656 ZDHHC9 1 GO:0032228 regulation of synaptic transmission, GABAergic 1/852 33/18722 0.785265595240264 0.86331186999656 PLCL2 1 GO:0035025 positive regulation of Rho protein signal transduction 1/852 33/18722 0.785265595240264 0.86331186999656 F11R 1 GO:0040020 regulation of meiotic nuclear division 1/852 33/18722 0.785265595240264 0.86331186999656 CALR 1 GO:0042558 pteridine-containing compound metabolic process 1/852 33/18722 0.785265595240264 0.86331186999656 PIPOX 1 GO:0045920 negative regulation of exocytosis 1/852 33/18722 0.785265595240264 0.86331186999656 FMR1 1 GO:0048333 mesodermal cell differentiation 1/852 33/18722 0.785265595240264 0.86331186999656 ITGB1 1 GO:0050974 detection of mechanical stimulus involved in sensory perception 1/852 33/18722 0.785265595240264 0.86331186999656 SERPINE2 1 GO:0060122 inner ear receptor cell stereocilium organization 1/852 33/18722 0.785265595240264 0.86331186999656 SDC4 1 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 1/852 33/18722 0.785265595240264 0.86331186999656 TP53 1 GO:1903715 regulation of aerobic respiration 1/852 33/18722 0.785265595240264 0.86331186999656 PINK1 1 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 1/852 33/18722 0.785265595240264 0.86331186999656 ADAM17 1 GO:0045143 homologous chromosome segregation 2/852 63/18722 0.787634278552493 0.865537843658231 P3H4/CCNE1 2 GO:0046902 regulation of mitochondrial membrane permeability 2/852 63/18722 0.787634278552493 0.865537843658231 TMEM14A/TP53 2 GO:0042147 retrograde transport, endosome to Golgi 3/852 91/18722 0.789335575883288 0.866839614536459 CLN5/TBC1D10A/RHOBTB3 3 GO:0051952 regulation of amine transport 3/852 91/18722 0.789335575883288 0.866839614536459 ITGB1/SYT8/PINK1 3 GO:0098661 inorganic anion transmembrane transport 3/852 91/18722 0.789335575883288 0.866839614536459 SLC12A8/PCYOX1/SLC1A3 3 GO:0002443 leukocyte mediated immunity 17/852 440/18722 0.789525362007325 0.866858888957868 HLA-G/IL1R1/SERPING1/GATA3/DNASE1L3/GATA2/TGFB1/PVR/SNAP23/LAMP1/BST2/S100A13/ARL8B/AP1G1/CTSH/NDFIP1/ADAM17 17 GO:0007269 neurotransmitter secretion 5/852 145/18722 0.794715948587995 0.870461537459371 SYT8/STXBP5/SNAP23/CTBP2/FMR1 5 GO:0099643 signal release from synapse 5/852 145/18722 0.794715948587995 0.870461537459371 SYT8/STXBP5/SNAP23/CTBP2/FMR1 5 GO:0006940 regulation of smooth muscle contraction 2/852 64/18722 0.794906999277342 0.870461537459371 DOCK5/CTTN 2 GO:0048857 neural nucleus development 2/852 64/18722 0.794906999277342 0.870461537459371 ACTB/SEC16A 2 GO:0002183 cytoplasmic translational initiation 1/852 34/18722 0.795054974707079 0.870461537459371 EIF4B 1 GO:0006270 DNA replication initiation 1/852 34/18722 0.795054974707079 0.870461537459371 CCNE1 1 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/852 34/18722 0.795054974707079 0.870461537459371 SRI 1 GO:0031128 developmental induction 1/852 34/18722 0.795054974707079 0.870461537459371 CTNNB1 1 GO:0035137 hindlimb morphogenesis 1/852 34/18722 0.795054974707079 0.870461537459371 CTNNB1 1 GO:0035590 purinergic nucleotide receptor signaling pathway 1/852 34/18722 0.795054974707079 0.870461537459371 P2RX4 1 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1/852 34/18722 0.795054974707079 0.870461537459371 SEC14L1 1 GO:0048854 brain morphogenesis 1/852 34/18722 0.795054974707079 0.870461537459371 GBA 1 GO:0070050 neuron cellular homeostasis 1/852 34/18722 0.795054974707079 0.870461537459371 SLC6A2 1 GO:0035249 synaptic transmission, glutamatergic 3/852 92/18722 0.795454206740824 0.870519900527629 SERPINE2/PTK2B/DGKZ 3 GO:0048525 negative regulation of viral process 3/852 92/18722 0.795454206740824 0.870519900527629 ISG15/BST2/GSN 3 GO:0015931 nucleobase-containing compound transport 8/852 222/18722 0.79679112622986 0.871793421372801 SLC35A3/IGF2BP2/ZFP36L1/XPOT/ZC3H11A/FMR1/MYO1C/IGF2BP3 8 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 5/852 146/18722 0.799569361796716 0.874643033671565 ADM/ADGRE5/ABCA1/ADCY7/GNAQ 5 GO:0002221 pattern recognition receptor signaling pathway 6/852 172/18722 0.800100234479363 0.874981200995716 PTPRS/TNFAIP3/RTN4/SLC15A3/XIAP/SEC14L1 6 GO:0002764 immune response-regulating signaling pathway 18/852 468/18722 0.800879174846448 0.874981200995716 HLA-G/GATA3/PLCL2/CD276/PTPRS/CMTM3/TNFAIP3/CBLB/RTN4/PLEKHA1/DGKZ/PTK2/SLC15A3/LGALS3/CTSH/EZR/XIAP/SEC14L1 18 GO:1901796 regulation of signal transduction by p53 class mediator 3/852 93/18722 0.801423774657303 0.874981200995716 NUAK1/MIF/TP53 3 GO:0038034 signal transduction in absence of ligand 2/852 65/18722 0.801958578567352 0.874981200995716 FGFR1/ERBB3 2 GO:0090307 mitotic spindle assembly 2/852 65/18722 0.801958578567352 0.874981200995716 FLNA/CCSAP 2 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 2/852 65/18722 0.801958578567352 0.874981200995716 FGFR1/ERBB3 2 GO:0000731 DNA synthesis involved in DNA repair 1/852 35/18722 0.804398572820819 0.874981200995716 FAAP20 1 GO:0003298 physiological muscle hypertrophy 1/852 35/18722 0.804398572820819 0.874981200995716 PDLIM5 1 GO:0003301 physiological cardiac muscle hypertrophy 1/852 35/18722 0.804398572820819 0.874981200995716 PDLIM5 1 GO:0006084 acetyl-CoA metabolic process 1/852 35/18722 0.804398572820819 0.874981200995716 PIPOX 1 GO:0007020 microtubule nucleation 1/852 35/18722 0.804398572820819 0.874981200995716 ARHGEF7 1 GO:0009119 ribonucleoside metabolic process 1/852 35/18722 0.804398572820819 0.874981200995716 AMD1 1 GO:0010664 negative regulation of striated muscle cell apoptotic process 1/852 35/18722 0.804398572820819 0.874981200995716 MDK 1 GO:0019068 virion assembly 1/852 35/18722 0.804398572820819 0.874981200995716 APOE 1 GO:0032205 negative regulation of telomere maintenance 1/852 35/18722 0.804398572820819 0.874981200995716 TNKS2 1 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 1/852 35/18722 0.804398572820819 0.874981200995716 CARM1 1 GO:0040001 establishment of mitotic spindle localization 1/852 35/18722 0.804398572820819 0.874981200995716 ITGB1 1 GO:0045880 positive regulation of smoothened signaling pathway 1/852 35/18722 0.804398572820819 0.874981200995716 SFRP1 1 GO:0045907 positive regulation of vasoconstriction 1/852 35/18722 0.804398572820819 0.874981200995716 GJA5 1 GO:0046471 phosphatidylglycerol metabolic process 1/852 35/18722 0.804398572820819 0.874981200995716 LPCAT1 1 GO:0060236 regulation of mitotic spindle organization 1/852 35/18722 0.804398572820819 0.874981200995716 CCSAP 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/852 35/18722 0.804398572820819 0.874981200995716 PDLIM5 1 GO:0071108 protein K48-linked deubiquitination 1/852 35/18722 0.804398572820819 0.874981200995716 TNFAIP3 1 GO:0072528 pyrimidine-containing compound biosynthetic process 1/852 35/18722 0.804398572820819 0.874981200995716 CMPK1 1 GO:0097421 liver regeneration 1/852 35/18722 0.804398572820819 0.874981200995716 PTPN3 1 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1/852 35/18722 0.804398572820819 0.874981200995716 SRI 1 GO:1901990 regulation of mitotic cell cycle phase transition 11/852 299/18722 0.805101023357853 0.875556061054467 ADAMTS1/SOX4/RPS27L/PLK2/ZFP36L1/JADE1/CTDSP1/TP53/DDB1/WEE1/ADAM17 11 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 2/852 66/18722 0.808794053947838 0.878472449688169 TGFB1/NDFIP1 2 GO:0016444 somatic cell DNA recombination 2/852 66/18722 0.808794053947838 0.878472449688169 TGFB1/NDFIP1 2 GO:0032715 negative regulation of interleukin-6 production 2/852 66/18722 0.808794053947838 0.878472449688169 TNFAIP3/GBA 2 GO:0071300 cellular response to retinoic acid 2/852 66/18722 0.808794053947838 0.878472449688169 PTK2B/ABCA1 2 GO:1905953 negative regulation of lipid localization 2/852 66/18722 0.808794053947838 0.878472449688169 APOC1/ABCA1 2 GO:0010212 response to ionizing radiation 5/852 148/18722 0.809004530956619 0.878472449688169 SFRP1/GATA3/DNM2/EGR1/TP53 5 GO:0070507 regulation of microtubule cytoskeleton organization 5/852 148/18722 0.809004530956619 0.878472449688169 MAPRE2/PHLDB2/ARHGEF2/CCSAP/ARHGEF7 5 GO:0032479 regulation of type I interferon production 3/852 95/18722 0.812924667069509 0.880495328527822 PTPRS/ISG15/DTX4 3 GO:0032606 type I interferon production 3/852 95/18722 0.812924667069509 0.880495328527822 PTPRS/ISG15/DTX4 3 GO:0022900 electron transport chain 6/852 175/18722 0.813093081502486 0.880495328527822 P4HA2/PDIA5/DHRS3/GBA/PINK1/UQCR11 6 GO:0003352 regulation of cilium movement 1/852 36/18722 0.81331666646649 0.880495328527822 CCSAP 1 GO:0007031 peroxisome organization 1/852 36/18722 0.81331666646649 0.880495328527822 RAB8B 1 GO:0010092 specification of animal organ identity 1/852 36/18722 0.81331666646649 0.880495328527822 CTNNB1 1 GO:0017004 cytochrome complex assembly 1/852 36/18722 0.81331666646649 0.880495328527822 PET100 1 GO:0042755 eating behavior 1/852 36/18722 0.81331666646649 0.880495328527822 GDF15 1 GO:0043949 regulation of cAMP-mediated signaling 1/852 36/18722 0.81331666646649 0.880495328527822 POMC 1 GO:0045652 regulation of megakaryocyte differentiation 1/852 36/18722 0.81331666646649 0.880495328527822 GATA2 1 GO:0051955 regulation of amino acid transport 1/852 36/18722 0.81331666646649 0.880495328527822 ITGB1 1 GO:0070897 transcription preinitiation complex assembly 1/852 36/18722 0.81331666646649 0.880495328527822 TP53 1 GO:0090322 regulation of superoxide metabolic process 1/852 36/18722 0.81331666646649 0.880495328527822 TGFB1 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/852 36/18722 0.81331666646649 0.880495328527822 MIF 1 GO:0051054 positive regulation of DNA metabolic process 7/852 201/18722 0.814075361416383 0.881127160001861 TGFB1/PTK2B/ENDOG/TNKS2/GRHL2/CTNNB1/MAPK3 7 GO:0009583 detection of light stimulus 2/852 67/18722 0.815418462944115 0.882011846979955 OPN3/GNAQ 2 GO:0016445 somatic diversification of immunoglobulins 2/852 67/18722 0.815418462944115 0.882011846979955 TGFB1/NDFIP1 2 GO:0046635 positive regulation of alpha-beta T cell activation 2/852 67/18722 0.815418462944115 0.882011846979955 EBI3/HSPH1 2 GO:0031570 DNA integrity checkpoint signaling 4/852 123/18722 0.816536395014645 0.883031301269598 SOX4/RPS27L/PLK2/TP53 4 GO:0009132 nucleoside diphosphate metabolic process 4/852 124/18722 0.821391990356042 0.886603996222475 PRKAG2/INSR/TJP2/CMPK1 4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1/852 37/18722 0.821828611247104 0.886603996222475 PABPC1 1 GO:0001990 regulation of systemic arterial blood pressure by hormone 1/852 37/18722 0.821828611247104 0.886603996222475 CTSZ 1 GO:0007340 acrosome reaction 1/852 37/18722 0.821828611247104 0.886603996222475 B4GALT1 1 GO:0033120 positive regulation of RNA splicing 1/852 37/18722 0.821828611247104 0.886603996222475 PIK3R1 1 GO:0043368 positive T cell selection 1/852 37/18722 0.821828611247104 0.886603996222475 CTSL 1 GO:0071985 multivesicular body sorting pathway 1/852 37/18722 0.821828611247104 0.886603996222475 TMEM50A 1 GO:0072529 pyrimidine-containing compound catabolic process 1/852 37/18722 0.821828611247104 0.886603996222475 TET3 1 GO:0097484 dendrite extension 1/852 37/18722 0.821828611247104 0.886603996222475 SLC23A2 1 GO:1900077 negative regulation of cellular response to insulin stimulus 1/852 37/18722 0.821828611247104 0.886603996222475 LPL 1 GO:1901016 regulation of potassium ion transmembrane transporter activity 2/852 68/18722 0.821836832660556 0.886603996222475 ITGB1/DNM2 2 GO:0006839 mitochondrial transport 9/852 254/18722 0.8219539531838 0.886603996222475 TSPO/SLC39A8/SFXN3/RHOU/LMAN1/PINK1/TMEM14A/TP53/SH3GLB1 9 GO:1990868 response to chemokine 3/852 97/18722 0.823856554128318 0.888275500627212 PTK2B/CCR1/ACKR2 3 GO:1990869 cellular response to chemokine 3/852 97/18722 0.823856554128318 0.888275500627212 PTK2B/CCR1/ACKR2 3 GO:0009266 response to temperature stimulus 6/852 178/18722 0.825414151172328 0.889764279899406 PLAC8/ADM/LPL/PCSK1N/ERO1A/DNAJC3 6 GO:0003002 regionalization 12/852 331/18722 0.827882673814864 0.891655250139079 NOG/SFRP1/CITED2/ACVRL1/SMAD3/PCSK6/NOTCH2/TMED2/BMPR2/CTNNB1/TP53/ETS2 12 GO:0006368 transcription elongation from RNA polymerase II promoter 2/852 69/18722 0.828054170305991 0.891655250139079 ELL2/CTNNB1 2 GO:0031060 regulation of histone methylation 2/852 69/18722 0.828054170305991 0.891655250139079 GATA3/CTNNB1 2 GO:0045665 negative regulation of neuron differentiation 2/852 69/18722 0.828054170305991 0.891655250139079 CALR/CTDSP1 2 GO:0070192 chromosome organization involved in meiotic cell cycle 2/852 69/18722 0.828054170305991 0.891655250139079 P3H4/CCNE1 2 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 13/852 356/18722 0.828463641057704 0.891905348757952 EBI3/HLA-G/IL1R1/SERPING1/GATA3/IL18BP/TGFB1/PVR/TNFAIP3/PKN1/CTSH/NDFIP1/ADAM17 13 GO:0002385 mucosal immune response 1/852 38/18722 0.829952883295135 0.892363354331214 RPL39 1 GO:0007007 inner mitochondrial membrane organization 1/852 38/18722 0.829952883295135 0.892363354331214 PINK1 1 GO:0032717 negative regulation of interleukin-8 production 1/852 38/18722 0.829952883295135 0.892363354331214 ANXA4 1 GO:0032941 secretion by tissue 1/852 38/18722 0.829952883295135 0.892363354331214 COPA 1 GO:0098926 postsynaptic signal transduction 1/852 38/18722 0.829952883295135 0.892363354331214 GNAQ 1 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1/852 38/18722 0.829952883295135 0.892363354331214 TMEM14A 1 GO:0007338 single fertilization 5/852 153/18722 0.831046850827891 0.893348739901063 HEXB/CD9/B4GALT1/LY6K/MYH9 5 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 2/852 70/18722 0.834075454601071 0.896205167892471 TGFB1/NDFIP1 2 GO:0006165 nucleoside diphosphate phosphorylation 3/852 99/18722 0.834238269734994 0.896205167892471 PRKAG2/INSR/CMPK1 3 GO:0015837 amine transport 3/852 99/18722 0.834238269734994 0.896205167892471 ITGB1/SYT8/PINK1 3 GO:0017158 regulation of calcium ion-dependent exocytosis 1/852 39/18722 0.837707119188549 0.898397598737687 SYT8 1 GO:0032506 cytokinetic process 1/852 39/18722 0.837707119188549 0.898397598737687 MYH9 1 GO:0032728 positive regulation of interferon-beta production 1/852 39/18722 0.837707119188549 0.898397598737687 ISG15 1 GO:0034314 Arp2/3 complex-mediated actin nucleation 1/852 39/18722 0.837707119188549 0.898397598737687 NCKAP1 1 GO:0036297 interstrand cross-link repair 1/852 39/18722 0.837707119188549 0.898397598737687 FAAP20 1 GO:0043267 negative regulation of potassium ion transport 1/852 39/18722 0.837707119188549 0.898397598737687 PTK2B 1 GO:0090224 regulation of spindle organization 1/852 39/18722 0.837707119188549 0.898397598737687 CCSAP 1 GO:1902742 apoptotic process involved in development 1/852 39/18722 0.837707119188549 0.898397598737687 TGFB2 1 GO:0051588 regulation of neurotransmitter transport 3/852 100/18722 0.839228804244531 0.899796727492487 ITGB1/STXBP5/FMR1 3 GO:0033865 nucleoside bisphosphate metabolic process 4/852 128/18722 0.839763526227487 0.899796727492487 PIPOX/TECR/ACSL4/ACSL3 4 GO:0033875 ribonucleoside bisphosphate metabolic process 4/852 128/18722 0.839763526227487 0.899796727492487 PIPOX/TECR/ACSL4/ACSL3 4 GO:0034032 purine nucleoside bisphosphate metabolic process 4/852 128/18722 0.839763526227487 0.899796727492487 PIPOX/TECR/ACSL4/ACSL3 4 GO:0050795 regulation of behavior 2/852 71/18722 0.839905628007094 0.899796727492487 APOE/MDK 2 GO:0046939 nucleotide phosphorylation 3/852 101/18722 0.844089018399721 0.902871861466776 PRKAG2/INSR/CMPK1 3 GO:0007093 mitotic cell cycle checkpoint signaling 4/852 129/18722 0.844100889737156 0.902871861466776 SOX4/RPS27L/PLK2/TP53 4 GO:0002714 positive regulation of B cell mediated immunity 1/852 40/18722 0.845108154057219 0.902871861466776 TGFB1 1 GO:0002891 positive regulation of immunoglobulin mediated immune response 1/852 40/18722 0.845108154057219 0.902871861466776 TGFB1 1 GO:0006730 one-carbon metabolic process 1/852 40/18722 0.845108154057219 0.902871861466776 SFXN3 1 GO:0009069 serine family amino acid metabolic process 1/852 40/18722 0.845108154057219 0.902871861466776 SERINC3 1 GO:0009187 cyclic nucleotide metabolic process 1/852 40/18722 0.845108154057219 0.902871861466776 ADCY7 1 GO:0045740 positive regulation of DNA replication 1/852 40/18722 0.845108154057219 0.902871861466776 BCAR3 1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 1/852 40/18722 0.845108154057219 0.902871861466776 SRI 1 GO:0097352 autophagosome maturation 1/852 40/18722 0.845108154057219 0.902871861466776 LAMP2 1 GO:1901661 quinone metabolic process 1/852 40/18722 0.845108154057219 0.902871861466776 VKORC1 1 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 1/852 40/18722 0.845108154057219 0.902871861466776 TMEM14A 1 GO:2000142 regulation of DNA-templated transcription, initiation 1/852 40/18722 0.845108154057219 0.902871861466776 TP53 1 GO:0032456 endocytic recycling 2/852 73/18722 0.851012189372542 0.908240582007613 ANKRD50/ARHGAP1 2 GO:0070988 demethylation 2/852 73/18722 0.851012189372542 0.908240582007613 GATA3/TET3 2 GO:0002251 organ or tissue specific immune response 1/852 41/18722 0.852172057961685 0.908240582007613 RPL39 1 GO:0006418 tRNA aminoacylation for protein translation 1/852 41/18722 0.852172057961685 0.908240582007613 RARS2 1 GO:0007099 centriole replication 1/852 41/18722 0.852172057961685 0.908240582007613 PLK2 1 GO:0009167 purine ribonucleoside monophosphate metabolic process 1/852 41/18722 0.852172057961685 0.908240582007613 TJP2 1 GO:0031062 positive regulation of histone methylation 1/852 41/18722 0.852172057961685 0.908240582007613 CTNNB1 1 GO:0032733 positive regulation of interleukin-10 production 1/852 41/18722 0.852172057961685 0.908240582007613 ISG15 1 GO:0050691 regulation of defense response to virus by host 1/852 41/18722 0.852172057961685 0.908240582007613 TNFAIP3 1 GO:0055023 positive regulation of cardiac muscle tissue growth 1/852 41/18722 0.852172057961685 0.908240582007613 TGFBR3 1 GO:0070296 sarcoplasmic reticulum calcium ion transport 1/852 41/18722 0.852172057961685 0.908240582007613 SRI 1 GO:0000723 telomere maintenance 4/852 131/18722 0.852479338248354 0.908240582007613 TNKS2/CTNNB1/MAPK3/CCNE1 4 GO:0018022 peptidyl-lysine methylation 4/852 131/18722 0.852479338248354 0.908240582007613 GATA3/SMYD3/TET3/CTNNB1 4 GO:0009135 purine nucleoside diphosphate metabolic process 3/852 103/18722 0.853428230691121 0.908674483830847 PRKAG2/INSR/TJP2 3 GO:0009179 purine ribonucleoside diphosphate metabolic process 3/852 103/18722 0.853428230691121 0.908674483830847 PRKAG2/INSR/TJP2 3 GO:0019395 fatty acid oxidation 3/852 103/18722 0.853428230691121 0.908674483830847 PRKAG2/MFSD2A/ACOX1 3 GO:0002768 immune response-regulating cell surface receptor signaling pathway 11/852 315/18722 0.8536798114415 0.908750103846249 HLA-G/GATA3/PLCL2/CD276/CMTM3/CBLB/PLEKHA1/DGKZ/PTK2/LGALS3/EZR 11 GO:0006635 fatty acid beta-oxidation 2/852 74/18722 0.856298221405396 0.911344670825409 MFSD2A/ACOX1 2 GO:0002429 immune response-activating cell surface receptor signaling pathway 10/852 291/18722 0.85764537776459 0.912392556814454 GATA3/PLCL2/CD276/CMTM3/CBLB/PLEKHA1/DGKZ/PTK2/LGALS3/EZR 10 GO:0002757 immune response-activating signal transduction 10/852 291/18722 0.85764537776459 0.912392556814454 GATA3/PLCL2/CD276/CMTM3/CBLB/PLEKHA1/DGKZ/PTK2/LGALS3/EZR 10 GO:0010677 negative regulation of cellular carbohydrate metabolic process 1/852 42/18722 0.858914170622498 0.912777664852837 FAM3C 1 GO:0021879 forebrain neuron differentiation 1/852 42/18722 0.858914170622498 0.912777664852837 GATA2 1 GO:0033003 regulation of mast cell activation 1/852 42/18722 0.858914170622498 0.912777664852837 GATA2 1 GO:0071312 cellular response to alkaloid 1/852 42/18722 0.858914170622498 0.912777664852837 SLC1A3 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/852 42/18722 0.858914170622498 0.912777664852837 HDAC5 1 GO:0046328 regulation of JNK cascade 4/852 133/18722 0.860472827353213 0.914241025980308 SFRP1/PTK2B/PINK1/HIPK3 4 GO:1903363 negative regulation of cellular protein catabolic process 2/852 75/18722 0.861412420042097 0.915046160842522 EFNA1/FURIN 2 GO:0007601 visual perception 7/852 215/18722 0.863128895464205 0.916676035212354 TIMP3/EPAS1/CLDN19/LAMB2/WFS1/DHRS3/RDH10 7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1/852 43/18722 0.865349134574834 0.917678507019625 FXYD5 1 GO:0034142 toll-like receptor 4 signaling pathway 1/852 43/18722 0.865349134574834 0.917678507019625 TNFAIP3 1 GO:0034661 ncRNA catabolic process 1/852 43/18722 0.865349134574834 0.917678507019625 KCNQ1OT1 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/852 43/18722 0.865349134574834 0.917678507019625 CBLB 1 GO:0060443 mammary gland morphogenesis 1/852 43/18722 0.865349134574834 0.917678507019625 CSF1R 1 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 1/852 43/18722 0.865349134574834 0.917678507019625 TPM1 1 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/852 43/18722 0.865349134574834 0.917678507019625 FGFR1 1 GO:0014823 response to activity 2/852 76/18722 0.866359454841768 0.91814702323532 COL4A2/PTN 2 GO:0071426 ribonucleoprotein complex export from nucleus 2/852 76/18722 0.866359454841768 0.91814702323532 XPOT/ZC3H11A 2 GO:0140115 export across plasma membrane 2/852 76/18722 0.866359454841768 0.91814702323532 RALBP1/ABCA1 2 GO:0007218 neuropeptide signaling pathway 3/852 106/18722 0.866520635876768 0.91814702323532 TAC3/POMC/PCSK1N 3 GO:0019693 ribose phosphate metabolic process 14/852 396/18722 0.867029936685398 0.918493300639362 PRKAG2/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/PYGL/TJP2/RFK/CMPK1/ACSL3 14 GO:0009566 fertilization 6/852 190/18722 0.868344501511966 0.919498816770403 HEXB/CD9/B4GALT1/LY6K/CLIC4/MYH9 6 GO:0099111 microtubule-based transport 6/852 190/18722 0.868344501511966 0.919498816770403 HSPB1/AP3S1/LAMP1/SUN2/COPG1/ARL8B 6 GO:0042303 molting cycle 3/852 107/18722 0.870650145538073 0.920313435728841 TGFB2/CTNNB1/LAMA5 3 GO:0042633 hair cycle 3/852 107/18722 0.870650145538073 0.920313435728841 TGFB2/CTNNB1/LAMA5 3 GO:0002200 somatic diversification of immune receptors 2/852 77/18722 0.871143926777423 0.920313435728841 TGFB1/NDFIP1 2 GO:0006367 transcription initiation from RNA polymerase II promoter 2/852 77/18722 0.871143926777423 0.920313435728841 TAF13/TP53 2 GO:0071166 ribonucleoprotein complex localization 2/852 77/18722 0.871143926777423 0.920313435728841 XPOT/ZC3H11A 2 GO:0009126 purine nucleoside monophosphate metabolic process 1/852 44/18722 0.871490926819721 0.920313435728841 TJP2 1 GO:0032007 negative regulation of TOR signaling 1/852 44/18722 0.871490926819721 0.920313435728841 SH3BP4 1 GO:0032620 interleukin-17 production 1/852 44/18722 0.871490926819721 0.920313435728841 TGFB1 1 GO:0032660 regulation of interleukin-17 production 1/852 44/18722 0.871490926819721 0.920313435728841 TGFB1 1 GO:0043039 tRNA aminoacylation 1/852 44/18722 0.871490926819721 0.920313435728841 RARS2 1 GO:0046006 regulation of activated T cell proliferation 1/852 44/18722 0.871490926819721 0.920313435728841 IGF2 1 GO:0048806 genitalia development 1/852 44/18722 0.871490926819721 0.920313435728841 CTNNB1 1 GO:0051150 regulation of smooth muscle cell differentiation 1/852 44/18722 0.871490926819721 0.920313435728841 ENG 1 GO:0050953 sensory perception of light stimulus 7/852 219/18722 0.87502566865191 0.923852357945262 TIMP3/EPAS1/CLDN19/LAMB2/WFS1/DHRS3/RDH10 7 GO:0060078 regulation of postsynaptic membrane potential 4/852 137/18722 0.875353973116622 0.924005148216434 PTK2B/SH3GL1/PPP3CA/P2RX4 4 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 2/852 78/18722 0.875770364804631 0.92405707464606 PSAP/FLNA 2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 2/852 78/18722 0.875770364804631 0.92405707464606 HERPUD1/XIAP 2 GO:0010824 regulation of centrosome duplication 1/852 45/18722 0.877352889039958 0.924370335050892 PLK2 1 GO:0043038 amino acid activation 1/852 45/18722 0.877352889039958 0.924370335050892 RARS2 1 GO:0045910 negative regulation of DNA recombination 1/852 45/18722 0.877352889039958 0.924370335050892 NDFIP1 1 GO:0045933 positive regulation of muscle contraction 1/852 45/18722 0.877352889039958 0.924370335050892 CTTN 1 GO:0060421 positive regulation of heart growth 1/852 45/18722 0.877352889039958 0.924370335050892 TGFBR3 1 GO:0098534 centriole assembly 1/852 45/18722 0.877352889039958 0.924370335050892 PLK2 1 GO:1904646 cellular response to amyloid-beta 1/852 45/18722 0.877352889039958 0.924370335050892 LRP1 1 GO:0061013 regulation of mRNA catabolic process 5/852 166/18722 0.878771155661041 0.925670830146927 MEX3D/PABPC1/ZFP36L1/FMR1/PKP3 5 GO:0001895 retina homeostasis 2/852 79/18722 0.880243222883675 0.927027441049076 ACTB/HSPB1 2 GO:0006939 smooth muscle contraction 3/852 110/18722 0.882368670011072 0.929071446896595 DOCK5/EDNRB/CTTN 3 GO:0060976 coronary vasculature development 1/852 46/18722 0.882947756445749 0.929292358467473 TGFBR3 1 GO:2000107 negative regulation of leukocyte apoptotic process 1/852 46/18722 0.882947756445749 0.929292358467473 EFNA1 1 GO:1901988 negative regulation of cell cycle phase transition 8/852 249/18722 0.884272077277757 0.93049160881015 SOX4/RPS27L/PLK2/ZFP36L1/JADE1/CTDSP1/TP53/WEE1 8 GO:0032369 negative regulation of lipid transport 1/852 47/18722 0.888287685312114 0.933741002542997 APOC1 1 GO:0045911 positive regulation of DNA recombination 1/852 47/18722 0.888287685312114 0.933741002542997 TGFB1 1 GO:0047496 vesicle transport along microtubule 1/852 47/18722 0.888287685312114 0.933741002542997 AP3S1 1 GO:0050798 activated T cell proliferation 1/852 47/18722 0.888287685312114 0.933741002542997 IGF2 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/852 47/18722 0.888287685312114 0.933741002542997 GATA2 1 GO:0006096 glycolytic process 2/852 81/18722 0.888745625098813 0.93402729820888 PRKAG2/INSR 2 GO:0006757 ATP generation from ADP 2/852 82/18722 0.892783681060572 0.937683695070505 PRKAG2/INSR 2 GO:0072527 pyrimidine-containing compound metabolic process 2/852 82/18722 0.892783681060572 0.937683695070505 TET3/CMPK1 2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 2/852 82/18722 0.892783681060572 0.937683695070505 ENDOG/RNASET2 2 GO:0042908 xenobiotic transport 1/852 48/18722 0.893384279267352 0.937923044962992 RALBP1 1 GO:0061647 histone H3-K9 modification 1/852 48/18722 0.893384279267352 0.937923044962992 GATA3 1 GO:0038061 NIK/NF-kappaB signaling 4/852 143/18722 0.895096544237131 0.939418717820581 SASH1/CALR/ACTN4/NFAT5 4 GO:0022412 cellular process involved in reproduction in multicellular organism 13/852 384/18722 0.89518223140622 0.939418717820581 HEXB/ITGB1/SFRP1/PTN/CD9/JAM2/PTK2B/PRDX4/FOXJ3/CTNNB1/PAQR7/GMCL1/MDK 13 GO:0022904 respiratory electron transport chain 3/852 114/18722 0.89651883271491 0.940407688684472 GBA/PINK1/UQCR11 3 GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/852 83/18722 0.896685177428329 0.940407688684472 GATA3/CTSL 2 GO:0046785 microtubule polymerization 2/852 83/18722 0.896685177428329 0.940407688684472 MAP7D3/ARHGEF7 2 GO:0006376 mRNA splice site selection 1/852 49/18722 0.898248614389137 0.94067525514368 SRSF6 1 GO:0014075 response to amine 1/852 49/18722 0.898248614389137 0.94067525514368 PPP3CA 1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1/852 49/18722 0.898248614389137 0.94067525514368 WWTR1 1 GO:0043330 response to exogenous dsRNA 1/852 49/18722 0.898248614389137 0.94067525514368 MAPK3 1 GO:0046605 regulation of centrosome cycle 1/852 49/18722 0.898248614389137 0.94067525514368 PLK2 1 GO:0050832 defense response to fungus 1/852 49/18722 0.898248614389137 0.94067525514368 COTL1 1 GO:0051445 regulation of meiotic cell cycle 1/852 49/18722 0.898248614389137 0.94067525514368 CALR 1 GO:0006405 RNA export from nucleus 2/852 84/18722 0.900454162121806 0.942788807563771 XPOT/ZC3H11A 2 GO:0006220 pyrimidine nucleotide metabolic process 1/852 50/18722 0.902891263162257 0.944279766990133 CMPK1 1 GO:0007140 male meiotic nuclear division 1/852 50/18722 0.902891263162257 0.944279766990133 FOXJ3 1 GO:0018023 peptidyl-lysine trimethylation 1/852 50/18722 0.902891263162257 0.944279766990133 TET3 1 GO:0038093 Fc receptor signaling pathway 1/852 50/18722 0.902891263162257 0.944279766990133 PTK2 1 GO:0007006 mitochondrial membrane organization 3/852 116/18722 0.903003878109181 0.944279766990133 PINK1/TMEM14A/TP53 3 GO:0031123 RNA 3'-end processing 3/852 116/18722 0.903003878109181 0.944279766990133 PABPC1/ZFP36L1/SYMPK 3 GO:0072521 purine-containing compound metabolic process 14/852 416/18722 0.906756125784856 0.94771845476182 TTR/PRKAG2/GUCA2A/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/AMD1/TJP2/ACSL3 14 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/852 51/18722 0.907322317349583 0.94771845476182 PINK1 1 GO:0021872 forebrain generation of neurons 1/852 51/18722 0.907322317349583 0.94771845476182 GATA2 1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 1/852 51/18722 0.907322317349583 0.94771845476182 TNFAIP3 1 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 1/852 51/18722 0.907322317349583 0.94771845476182 GATA3 1 GO:0046928 regulation of neurotransmitter secretion 2/852 86/18722 0.907610362001187 0.94771845476182 STXBP5/FMR1 2 GO:2000117 negative regulation of cysteine-type endopeptidase activity 2/852 86/18722 0.907610362001187 0.94771845476182 HERPUD1/XIAP 2 GO:1903313 positive regulation of mRNA metabolic process 3/852 118/18722 0.909119688359705 0.949097571357477 MEX3D/PABPC1/ZFP36L1 3 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 7/852 233/18722 0.910101992803348 0.949926032720707 ADM/PSAP/FLNA/ADGRE5/ABCA1/ADCY7/GNAQ 7 GO:0019646 aerobic electron transport chain 2/852 87/18722 0.91100524516143 0.950474585177752 PINK1/UQCR11 2 GO:1901606 alpha-amino acid catabolic process 2/852 87/18722 0.91100524516143 0.950474585177752 PIPOX/GLS 2 GO:0035176 social behavior 1/852 52/18722 0.911551409825516 0.950847304798305 EIF4EBP2 1 GO:1903311 regulation of mRNA metabolic process 9/852 288/18722 0.911837798795934 0.950948951790289 MBNL2/MEX3D/PABPC1/ZFP36L1/RBFOX2/SRSF6/FMR1/PKP3/DDX17 9 GO:0032784 regulation of DNA-templated transcription, elongation 1/852 53/18722 0.91558773541891 0.954266529791546 CTNNB1 1 GO:0051438 regulation of ubiquitin-protein transferase activity 1/852 53/18722 0.91558773541891 0.954266529791546 PINK1 1 GO:1990090 cellular response to nerve growth factor stimulus 1/852 53/18722 0.91558773541891 0.954266529791546 ID1 1 GO:0002224 toll-like receptor signaling pathway 3/852 121/18722 0.917639312208795 0.956008830127689 PTPRS/TNFAIP3/RTN4 3 GO:0045931 positive regulation of mitotic cell cycle 3/852 121/18722 0.917639312208795 0.956008830127689 ADAMTS1/EIF4EBP1/ADAM17 3 GO:0006479 protein methylation 5/852 181/18722 0.919092215794296 0.956696687283145 GATA3/SMYD3/TET3/CTNNB1/CARM1 5 GO:0008213 protein alkylation 5/852 181/18722 0.919092215794296 0.956696687283145 GATA3/SMYD3/TET3/CTNNB1/CARM1 5 GO:0051703 biological process involved in intraspecies interaction between organisms 1/852 54/18722 0.919440070810366 0.956696687283145 EIF4EBP2 1 GO:0070839 metal ion export 1/852 54/18722 0.919440070810366 0.956696687283145 ATOX1 1 GO:0072348 sulfur compound transport 1/852 54/18722 0.919440070810366 0.956696687283145 MFSD12 1 GO:0072698 protein localization to microtubule cytoskeleton 1/852 54/18722 0.919440070810366 0.956696687283145 MAPRE2 1 GO:0032392 DNA geometric change 2/852 90/18722 0.920501223253685 0.957404971406447 NAV2/HMGB3 2 GO:0046031 ADP metabolic process 2/852 90/18722 0.920501223253685 0.957404971406447 PRKAG2/INSR 2 GO:0010948 negative regulation of cell cycle process 9/852 294/18722 0.922843918911276 0.959134356279967 HLA-G/SOX4/RPS27L/PLK2/ZFP36L1/JADE1/CTDSP1/TP53/WEE1 9 GO:0002067 glandular epithelial cell differentiation 1/852 55/18722 0.923116793526756 0.959134356279967 RHEB 1 GO:0008333 endosome to lysosome transport 1/852 55/18722 0.923116793526756 0.959134356279967 ARL8B 1 GO:0031113 regulation of microtubule polymerization 1/852 55/18722 0.923116793526756 0.959134356279967 ARHGEF7 1 GO:0043331 response to dsRNA 1/852 55/18722 0.923116793526756 0.959134356279967 MAPK3 1 GO:0006354 DNA-templated transcription, elongation 2/852 91/18722 0.923448765891222 0.959281246384008 ELL2/CTNNB1 2 GO:0002253 activation of immune response 12/852 375/18722 0.924519636090187 0.960195486678067 SERPING1/GATA3/PLCL2/CD276/CMTM3/CD59/CBLB/PLEKHA1/DGKZ/PTK2/LGALS3/EZR 12 GO:0001708 cell fate specification 2/852 92/18722 0.926293089427898 0.961130446782336 ITGB1/CTNNB1 2 GO:0032465 regulation of cytokinesis 2/852 92/18722 0.926293089427898 0.961130446782336 PLK2/SH3GLB1 2 GO:0070509 calcium ion import 2/852 92/18722 0.926293089427898 0.961130446782336 CTNNB1/LGALS3 2 GO:0031122 cytoplasmic microtubule organization 1/852 56/18722 0.926625900073882 0.961130446782336 EZR 1 GO:0048255 mRNA stabilization 1/852 56/18722 0.926625900073882 0.961130446782336 PABPC1 1 GO:0070534 protein K63-linked ubiquitination 1/852 56/18722 0.926625900073882 0.961130446782336 SASH1 1 GO:0002449 lymphocyte mediated immunity 11/852 350/18722 0.926756617968344 0.961130446782336 HLA-G/IL1R1/SERPING1/GATA3/TGFB1/PVR/LAMP1/ARL8B/AP1G1/CTSH/NDFIP1 11 GO:0045132 meiotic chromosome segregation 2/852 93/18722 0.929037469972306 0.963098987923917 P3H4/CCNE1 2 GO:1901992 positive regulation of mitotic cell cycle phase transition 2/852 93/18722 0.929037469972306 0.963098987923917 ADAMTS1/ADAM17 2 GO:0030219 megakaryocyte differentiation 1/852 57/18722 0.929975023246338 0.963872383031058 GATA2 1 GO:1990830 cellular response to leukemia inhibitory factor 2/852 94/18722 0.931685099648577 0.965415599649373 CTBP2/KLF5 2 GO:0002377 immunoglobulin production 6/852 216/18722 0.931847602443205 0.965415599649373 TGFB1/EPHB2/XBP1/PKN1/NDFIP1/TMBIM6 6 GO:0043488 regulation of mRNA stability 4/852 158/18722 0.932897169813632 0.966190475429916 MEX3D/PABPC1/ZFP36L1/FMR1 4 GO:0032481 positive regulation of type I interferon production 1/852 58/18722 0.933171448651862 0.966190475429916 ISG15 1 GO:0044380 protein localization to cytoskeleton 1/852 58/18722 0.933171448651862 0.966190475429916 MAPRE2 1 GO:0042773 ATP synthesis coupled electron transport 2/852 95/18722 0.934239087445976 0.966699286002385 PINK1/UQCR11 2 GO:0042775 mitochondrial ATP synthesis coupled electron transport 2/852 95/18722 0.934239087445976 0.966699286002385 PINK1/UQCR11 2 GO:1990823 response to leukemia inhibitory factor 2/852 95/18722 0.934239087445976 0.966699286002385 CTBP2/KLF5 2 GO:0032200 telomere organization 4/852 159/18722 0.934914759584625 0.967199585814886 TNKS2/CTNNB1/MAPK3/CCNE1 4 GO:0007389 pattern specification process 14/852 436/18722 0.936152606409485 0.967955214201937 ENG/NOG/SFRP1/CITED2/ACVRL1/SMAD3/EFNB1/PCSK6/NOTCH2/TMED2/BMPR2/CTNNB1/TP53/ETS2 14 GO:0006406 mRNA export from nucleus 1/852 59/18722 0.9362221304858 0.967955214201937 ZC3H11A 1 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 1/852 59/18722 0.9362221304858 0.967955214201937 ZC3H11A 1 GO:0007127 meiosis I 3/852 129/18722 0.936914849174036 0.968472465782075 P3H4/FOXJ3/CCNE1 3 GO:0009259 ribonucleotide metabolic process 12/852 385/18722 0.938504285136866 0.969770198043844 PRKAG2/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/TJP2/RFK/CMPK1/ACSL3 12 GO:0007098 centrosome cycle 3/852 130/18722 0.939007192236319 0.969770198043844 PLK2/CTNNB1/SLC16A1 3 GO:0006081 cellular aldehyde metabolic process 1/852 60/18722 0.939133706589647 0.969770198043844 RDH10 1 GO:0009620 response to fungus 1/852 60/18722 0.939133706589647 0.969770198043844 COTL1 1 GO:0019731 antibacterial humoral response 1/852 60/18722 0.939133706589647 0.969770198043844 RPL39 1 GO:0007281 germ cell development 8/852 278/18722 0.940920893121832 0.971335132342428 HEXB/PTN/JAM2/PTK2B/CTNNB1/PAQR7/GMCL1/MDK 8 GO:0050853 B cell receptor signaling pathway 3/852 131/18722 0.941035188814162 0.971335132342428 PLCL2/CMTM3/PLEKHA1 3 GO:0042255 ribosome assembly 1/852 61/18722 0.94191251282615 0.972041352686901 RPS27L 1 GO:0007631 feeding behavior 2/852 99/18722 0.943577945230404 0.973381166196589 GDF15/GLS 2 GO:0007062 sister chromatid cohesion 1/852 62/18722 0.944564596801935 0.973381166196589 CTNNB1 1 GO:0009116 nucleoside metabolic process 1/852 62/18722 0.944564596801935 0.973381166196589 AMD1 1 GO:0032613 interleukin-10 production 1/852 62/18722 0.944564596801935 0.973381166196589 ISG15 1 GO:0032653 regulation of interleukin-10 production 1/852 62/18722 0.944564596801935 0.973381166196589 ISG15 1 GO:0032757 positive regulation of interleukin-8 production 1/852 62/18722 0.944564596801935 0.973381166196589 SERPINE1 1 GO:0048663 neuron fate commitment 1/852 62/18722 0.944564596801935 0.973381166196589 GATA2 1 GO:0009062 fatty acid catabolic process 2/852 100/18722 0.945707519536238 0.974359456668554 MFSD2A/ACOX1 2 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3/852 134/18722 0.946750317538441 0.97523420961338 ADM/DNM2/MGLL 3 GO:0050830 defense response to Gram-positive bacterium 2/852 101/18722 0.947760418549097 0.976074930746389 RPL39/ADAM17 2 GO:0061982 meiosis I cell cycle process 3/852 135/18722 0.948537970376365 0.976675860250459 P3H4/FOXJ3/CCNE1 3 GO:0006749 glutathione metabolic process 1/852 64/18722 0.949511425121057 0.976713811504644 GPX4 1 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 1/852 64/18722 0.949511425121057 0.976713811504644 EFNA1 1 GO:1903409 reactive oxygen species biosynthetic process 1/852 64/18722 0.949511425121057 0.976713811504644 ACOX1 1 GO:0032677 regulation of interleukin-8 production 2/852 102/18722 0.949739199980872 0.976713811504644 SERPINE1/ANXA4 2 GO:0035710 CD4-positive, alpha-beta T cell activation 2/852 102/18722 0.949739199980872 0.976713811504644 GATA3/CTSL 2 GO:1990542 mitochondrial transmembrane transport 2/852 102/18722 0.949739199980872 0.976713811504644 SLC39A8/SFXN3 2 GO:0006163 purine nucleotide metabolic process 12/852 396/18722 0.951253346137572 0.977851531069155 PRKAG2/GUCA2A/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/TJP2/ACSL3 12 GO:0032637 interleukin-8 production 2/852 103/18722 0.9516463478876 0.977851531069155 SERPINE1/ANXA4 2 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 2/852 103/18722 0.9516463478876 0.977851531069155 CSH1/PTK2B 2 GO:0043489 RNA stabilization 1/852 65/18722 0.951816938348458 0.977851531069155 PABPC1 1 GO:0061512 protein localization to cilium 1/852 65/18722 0.951816938348458 0.977851531069155 ARF4 1 GO:0000075 cell cycle checkpoint signaling 4/852 169/18722 0.952261523760059 0.978108622262117 SOX4/RPS27L/PLK2/TP53 4 GO:0007224 smoothened signaling pathway 3/852 138/18722 0.953571148581243 0.979226883147182 SERPINE2/SFRP1/HERC4 3 GO:0043487 regulation of RNA stability 4/852 170/18722 0.953739356484698 0.979226883147182 MEX3D/PABPC1/ZFP36L1/FMR1 4 GO:0042093 T-helper cell differentiation 1/852 66/18722 0.95401729041616 0.979312466380692 GATA3 1 GO:1903046 meiotic cell cycle process 5/852 202/18722 0.955580156251258 0.980468262683455 P3H4/CALR/FOXJ3/MYH9/CCNE1 5 GO:0051321 meiotic cell cycle 7/852 261/18722 0.955639546777519 0.980468262683455 P3H4/CALR/FOXJ3/MYH9/SUN2/SPIN1/CCNE1 7 GO:0006513 protein monoubiquitination 1/852 67/18722 0.956117272650585 0.980468262683455 DDB1 1 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/852 67/18722 0.956117272650585 0.980468262683455 CCR1 1 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 1/852 67/18722 0.956117272650585 0.980468262683455 GATA3 1 GO:0006090 pyruvate metabolic process 2/852 106/18722 0.956961755706021 0.981134348435201 PRKAG2/INSR 2 GO:0000910 cytokinesis 4/852 173/18722 0.957923760028585 0.981723391639865 PLK2/MYH9/RHOC/SH3GLB1 4 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 1/852 68/18722 0.958121458322078 0.981723391639865 GATA3 1 GO:0046637 regulation of alpha-beta T cell differentiation 1/852 68/18722 0.958121458322078 0.981723391639865 GATA3 1 GO:0044282 small molecule catabolic process 11/852 376/18722 0.958417966649211 0.981819886615758 PIPOX/APOE/MFSD2A/SCARB1/MGAT1/ACOX1/GLS/TP53/GLB1/GALE/IMPA2 11 GO:0000018 regulation of DNA recombination 2/852 107/18722 0.958605786375886 0.981819886615758 TGFB1/NDFIP1 2 GO:0002287 alpha-beta T cell activation involved in immune response 1/852 69/18722 0.960034212557609 0.982882870586339 GATA3 1 GO:0002293 alpha-beta T cell differentiation involved in immune response 1/852 69/18722 0.960034212557609 0.982882870586339 GATA3 1 GO:0031023 microtubule organizing center organization 3/852 143/18722 0.960950288633289 0.983620663553253 PLK2/CTNNB1/SLC16A1 3 GO:0008380 RNA splicing 13/852 434/18722 0.961452171520114 0.983895036811011 MBNL2/PTBP3/HNRNPH1/PABPC1/LGALS3/RBFOX2/SRSF6/TMBIM6/PIK3R1/AHNAK/FMR1/DDX17/RBM6 13 GO:0048285 organelle fission 15/852 488/18722 0.961609315730849 0.983895036811011 IGF2/RALBP1/P3H4/FLNA/INSR/CALR/FOXJ3/STAT2/INF2/PINK1/CAV2/CCSAP/REEP3/CCNE1/OBSL1 15 GO:0009063 cellular amino acid catabolic process 2/852 110/18722 0.963184493382731 0.985306413657578 PIPOX/GLS 2 GO:0000281 mitotic cytokinesis 1/852 71/18722 0.963601902857588 0.98533286815974 RHOC 1 GO:0008344 adult locomotory behavior 1/852 71/18722 0.963601902857588 0.98533286815974 ARCN1 1 GO:0000956 nuclear-transcribed mRNA catabolic process 2/852 112/18722 0.965962414190805 0.987345416454573 PABPC1/ZFP36L1 2 GO:0046632 alpha-beta T cell differentiation 2/852 112/18722 0.965962414190805 0.987345416454573 GATA3/CTSL 2 GO:1901361 organic cyclic compound catabolic process 15/852 495/18722 0.966744316906702 0.987451978758125 DIO2/MAOA/DNASE1L3/MEX3D/APOE/SCARB1/ENDOG/TET3/MGAT1/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 15 GO:0042274 ribosomal small subunit biogenesis 1/852 73/18722 0.966851450689458 0.987451978758125 RPS27L 1 GO:0051298 centrosome duplication 1/852 73/18722 0.966851450689458 0.987451978758125 PLK2 1 GO:1904427 positive regulation of calcium ion transmembrane transport 1/852 73/18722 0.966851450689458 0.987451978758125 SRI 1 GO:0002181 cytoplasmic translation 3/852 148/18722 0.967217046245469 0.987624953084488 RPL39/FMR1/EIF4B 3 GO:1901989 positive regulation of cell cycle phase transition 2/852 115/18722 0.969754618712759 0.98971064815697 ADAMTS1/ADAM17 2 GO:0002292 T cell differentiation involved in immune response 1/852 75/18722 0.969811195493894 0.98971064815697 GATA3 1 GO:1901987 regulation of cell cycle phase transition 11/852 390/18722 0.969849576139514 0.98971064815697 ADAMTS1/SOX4/RPS27L/PLK2/ZFP36L1/JADE1/CTDSP1/TP53/DDB1/WEE1/ADAM17 11 GO:0046034 ATP metabolic process 7/852 277/18722 0.971111612888386 0.990626201893543 TSPO/PRKAG2/TGFB1/INSR/PINK1/TP53/UQCR11 7 GO:0032543 mitochondrial translation 1/852 76/18722 0.971190552035922 0.990626201893543 RARS2 1 GO:0140013 meiotic nuclear division 4/852 185/18722 0.971396435316109 0.990626201893543 P3H4/CALR/FOXJ3/CCNE1 4 GO:0051092 positive regulation of NF-kappaB transcription factor activity 3/852 152/18722 0.971534061702072 0.990626201893543 IL1RAP/ARHGEF2/MTDH 3 GO:0006401 RNA catabolic process 7/852 278/18722 0.971891446978297 0.990789883054845 MEX3D/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 7 GO:0009150 purine ribonucleotide metabolic process 10/852 368/18722 0.973989396035845 0.992727547640423 PRKAG2/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/TJP2/ACSL3 10 GO:0000245 spliceosomal complex assembly 1/852 79/18722 0.974962249371872 0.993316801839804 SRSF6 1 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 1/852 79/18722 0.974962249371872 0.993316801839804 RPL39 1 GO:0045787 positive regulation of cell cycle 8/852 313/18722 0.975756083530073 0.993924381381675 IGF2/CITED2/ADAMTS1/TGFB2/EIF4EBP1/INSR/CALR/ADAM17 8 GO:0006338 chromatin remodeling 6/852 255/18722 0.977049627756309 0.99478965978058 GATA3/SMYD3/ACTB/HDAC5/MBD2/MBD3 6 GO:0072329 monocarboxylic acid catabolic process 2/852 122/18722 0.977085301531194 0.99478965978058 MFSD2A/ACOX1 2 GO:2001021 negative regulation of response to DNA damage stimulus 1/852 81/18722 0.977198505455034 0.99478965978058 MIF 1 GO:0043414 macromolecule methylation 8/852 316/18722 0.97761850361457 0.995015961312868 GATA3/SMYD3/TET3/GRHL2/CTNNB1/CARM1/MBD2/MBD3 8 GO:0140014 mitotic nuclear division 7/852 287/18722 0.978089534593974 0.995246666830246 IGF2/FLNA/INSR/CAV2/CCSAP/REEP3/OBSL1 7 GO:0007032 endosome organization 1/852 82/18722 0.978240663780892 0.995246666830246 SCARB2 1 GO:0009117 nucleotide metabolic process 14/852 489/18722 0.978921648638018 0.9957382088915 PRKAG2/GUCA2A/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/TJP2/RFK/CMPK1/ACSL3 14 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8/852 320/18722 0.979897583292456 0.996220138403271 MBNL2/HNRNPH1/PABPC1/RBFOX2/SRSF6/FMR1/DDX17/RBM6 8 GO:0000398 mRNA splicing, via spliceosome 8/852 320/18722 0.979897583292456 0.996220138403271 MBNL2/HNRNPH1/PABPC1/RBFOX2/SRSF6/FMR1/DDX17/RBM6 8 GO:0032508 DNA duplex unwinding 1/852 84/18722 0.980184412530475 0.996220138403271 NAV2 1 GO:0006260 DNA replication 6/852 260/18722 0.980187189623087 0.996220138403271 ACVRL1/ID3/BCAR3/TP53/ZBTB38/CCNE1 6 GO:0006325 chromatin organization 11/852 409/18722 0.980843039559891 0.996675676355678 GATA3/HMGN3/SMYD3/ACTB/HDAC5/BCORL1/MBD2/GPX4/SPIN1/TP53/MBD3 11 GO:0045333 cellular respiration 5/852 230/18722 0.981031452546399 0.996675676355678 GBA/PINK1/OPN3/IFNAR1/UQCR11 5 GO:0019439 aromatic compound catabolic process 13/852 467/18722 0.981518044482573 0.996815383464506 DIO2/MAOA/DNASE1L3/MEX3D/ENDOG/TET3/MGAT1/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 13 GO:0007018 microtubule-based movement 10/852 382/18722 0.981638099464422 0.996815383464506 KIF21A/HSPB1/AP3S1/LAMP1/SUN2/COPG1/CCSAP/ARL8B/KTN1/MAP4 10 GO:2001251 negative regulation of chromosome organization 1/852 86/18722 0.981954712852291 0.996815383464506 TNKS2 1 GO:0000375 RNA splicing, via transesterification reactions 8/852 324/18722 0.98196119038685 0.996815383464506 MBNL2/HNRNPH1/PABPC1/RBFOX2/SRSF6/FMR1/DDX17/RBM6 8 GO:0006402 mRNA catabolic process 5/852 232/18722 0.982185245993589 0.996841771140499 MEX3D/PABPC1/ZFP36L1/FMR1/PKP3 5 GO:0006753 nucleoside phosphate metabolic process 14/852 497/18722 0.982383573832875 0.996842041754206 PRKAG2/GUCA2A/PIPOX/TGFB1/INSR/TECR/ADCY7/PINK1/ACSL4/PRPSAP1/TJP2/RFK/CMPK1/ACSL3 14 GO:0006352 DNA-templated transcription, initiation 2/852 130/18722 0.983365442089562 0.997235194446255 TAF13/TP53 2 GO:0006956 complement activation 2/852 130/18722 0.983365442089562 0.997235194446255 SERPING1/CD59 2 GO:0030534 adult behavior 2/852 130/18722 0.983365442089562 0.997235194446255 ARCN1/NCSTN 2 GO:0050829 defense response to Gram-negative bacterium 1/852 88/18722 0.983567025681884 0.997238686594868 SERPINE1 1 GO:0046330 positive regulation of JNK cascade 1/852 89/18722 0.98431838846599 0.9977994862335 PTK2B 1 GO:0032259 methylation 9/852 364/18722 0.986311165305353 0.999479395922057 GATA3/SMYD3/TET3/GRHL2/CTNNB1/CARM1/MBD2/COMTD1/MBD3 9 GO:0034502 protein localization to chromosome 1/852 92/18722 0.986372771616303 0.999479395922057 TNKS2 1 GO:0033108 mitochondrial respiratory chain complex assembly 1/852 93/18722 0.986995981416782 0.999822389938273 PET100 1 GO:0060271 cilium assembly 8/852 337/18722 0.987391623382208 0.999822389938273 WWTR1/FLNA/PARVA/DNM2/LAMA5/ARF4/GSN/MAP4 8 GO:0000086 G2/M transition of mitotic cell cycle 2/852 137/18722 0.987461899020626 0.999822389938273 DNM2/WEE1 2 GO:0019724 B cell mediated immunity 4/852 210/18722 0.987587990836979 0.999822389938273 HLA-G/SERPING1/TGFB1/NDFIP1 4 GO:0044782 cilium organization 9/852 368/18722 0.987704534626086 0.999822389938273 WWTR1/FLNA/PARVA/DNM2/LAMA5/ARF4/TTC17/GSN/MAP4 9 GO:0016579 protein deubiquitination 2/852 139/18722 0.988439361663464 0.99999999954344 TNFAIP3/OTUD1 2 GO:0071466 cellular response to xenobiotic stimulus 3/852 177/18722 0.988485111492423 0.99999999954344 ABCA1/NCOA1/VKORC1 3 GO:0043648 dicarboxylic acid metabolic process 1/852 96/18722 0.988699933004254 0.99999999954344 GLS 1 GO:0006119 oxidative phosphorylation 2/852 141/18722 0.989342397539032 0.99999999954344 PINK1/UQCR11 2 GO:0034655 nucleobase-containing compound catabolic process 10/852 407/18722 0.990387942951129 0.99999999954344 DNASE1L3/MEX3D/ENDOG/MGAT1/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 10 GO:0006910 phagocytosis, recognition 1/852 100/18722 0.990630064092594 0.99999999954344 SCARB1 1 GO:0061640 cytoskeleton-dependent cytokinesis 1/852 100/18722 0.990630064092594 0.99999999954344 RHOC 1 GO:0000280 nuclear division 11/852 439/18722 0.990982342183663 0.99999999954344 IGF2/P3H4/FLNA/INSR/CALR/FOXJ3/CAV2/CCSAP/REEP3/CCNE1/OBSL1 11 GO:0042742 defense response to bacterium 8/852 350/18722 0.991265855163471 0.99999999954344 PRG2/SERPINE1/PLAC8/GRN/NOTCH2/ISG15/RPL39/ADAM17 8 GO:0044839 cell cycle G2/M phase transition 2/852 148/18722 0.991992716445769 0.99999999954344 DNM2/WEE1 2 GO:0033044 regulation of chromosome organization 3/852 187/18722 0.992059111721658 0.99999999954344 TNKS2/CTNNB1/MAPK3 3 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1/852 104/18722 0.992230835227755 0.99999999954344 EDNRB 1 GO:0046700 heterocycle catabolic process 11/852 445/18722 0.992283529080763 0.99999999954344 DNASE1L3/MEX3D/ENDOG/TET3/MGAT1/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 11 GO:2001022 positive regulation of response to DNA damage stimulus 1/852 105/18722 0.992586369032995 0.99999999954344 FMR1 1 GO:0031497 chromatin assembly 2/852 151/18722 0.99292023290753 0.99999999954344 SMYD3/TP53 2 GO:0090501 RNA phosphodiester bond hydrolysis 2/852 152/18722 0.993205381856936 0.99999999954344 ENDOG/RNASET2 2 GO:0044270 cellular nitrogen compound catabolic process 11/852 451/18722 0.993407688065781 0.99999999954344 DNASE1L3/MEX3D/ENDOG/TET3/MGAT1/PABPC1/ZFP36L1/RNASET2/FMR1/PKP3/KCNQ1OT1 11 GO:0006958 complement activation, classical pathway 1/852 108/18722 0.993558394164693 0.99999999954344 SERPING1 1 GO:0140053 mitochondrial gene expression 1/852 108/18722 0.993558394164693 0.99999999954344 RARS2 1 GO:0006805 xenobiotic metabolic process 1/852 111/18722 0.994403103739122 0.99999999954344 VKORC1 1 GO:0070646 protein modification by small protein removal 2/852 157/18722 0.994470775271917 0.99999999954344 TNFAIP3/OTUD1 2 GO:0001578 microtubule bundle formation 1/852 113/18722 0.99490383203021 0.99999999954344 NAV1 1 GO:0046395 carboxylic acid catabolic process 4/852 236/18722 0.994981592825653 0.99999999954344 PIPOX/MFSD2A/ACOX1/GLS 4 GO:0090068 positive regulation of cell cycle process 4/852 236/18722 0.994981592825653 0.99999999954344 IGF2/ADAMTS1/INSR/ADAM17 4 GO:0016054 organic acid catabolic process 4/852 240/18722 0.995647002133489 0.99999999954344 PIPOX/MFSD2A/ACOX1/GLS 4 GO:0016064 immunoglobulin mediated immune response 3/852 207/18722 0.996275620449932 0.99999999954344 SERPING1/TGFB1/NDFIP1 3 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/852 121/18722 0.996497445981131 0.99999999954344 SERPING1 1 GO:0006959 humoral immune response 6/852 317/18722 0.996637404161274 0.99999999954344 EBI3/SERPING1/GATA3/NOTCH2/CD59/RPL39 6 GO:0019730 antimicrobial humoral response 1/852 122/18722 0.996657876926998 0.99999999954344 RPL39 1 GO:0060294 cilium movement involved in cell motility 1/852 125/18722 0.997096455388274 0.99999999954344 CCSAP 1 GO:0006334 nucleosome assembly 1/852 129/18722 0.997593121180156 0.99999999954344 SMYD3 1 GO:0006333 chromatin assembly or disassembly 2/852 177/18722 0.997594920240541 0.99999999954344 SMYD3/TP53 2 GO:2001020 regulation of response to DNA damage stimulus 3/852 219/18722 0.997653986463976 0.99999999954344 MIF/TP53/FMR1 3 GO:0022618 ribonucleoprotein complex assembly 3/852 220/18722 0.997743178749741 0.99999999954344 RPS27L/SRSF6/EIF4B 3 GO:0090305 nucleic acid phosphodiester bond hydrolysis 4/852 261/18722 0.997960550579547 0.99999999954344 DNASE1L3/ENDOG/PLD3/RNASET2 4 GO:0071826 ribonucleoprotein complex subunit organization 3/852 227/18722 0.998281189260589 0.99999999954344 RPS27L/SRSF6/EIF4B 3 GO:0001539 cilium or flagellum-dependent cell motility 1/852 138/18722 0.998422129091905 0.99999999954344 CCSAP 1 GO:0060285 cilium-dependent cell motility 1/852 138/18722 0.998422129091905 0.99999999954344 CCSAP 1 GO:0009060 aerobic respiration 2/852 189/18722 0.998548558813201 0.99999999954344 PINK1/UQCR11 2 GO:0006323 DNA packaging 2/852 199/18722 0.999049813918776 0.99999999954344 SMYD3/TP53 2 GO:0065004 protein-DNA complex assembly 2/852 201/18722 0.999127256584022 0.99999999954344 SMYD3/TP53 2 GO:0006261 DNA-dependent DNA replication 1/852 151/18722 0.99914291344739 0.99999999954344 CCNE1 1 GO:0071103 DNA conformation change 4/852 290/18722 0.999303965490137 0.99999999954344 SMYD3/NAV2/HMGB3/TP53 4 GO:0007286 spermatid development 1/852 165/18722 0.999556005942666 0.99999999954344 JAM2 1 GO:0034728 nucleosome organization 1/852 167/18722 0.999595840903758 0.99999999954344 SMYD3 1 GO:0006310 DNA recombination 4/852 305/18722 0.999605280799222 0.99999999954344 TGFB1/ENDOG/HMGB3/NDFIP1 4 GO:0048515 spermatid differentiation 1/852 172/18722 0.999680500160279 0.99999999954344 JAM2 1 GO:0003341 cilium movement 1/852 175/18722 0.999722535073222 0.99999999954344 CCSAP 1 GO:0006399 tRNA metabolic process 1/852 179/18722 0.999770115913907 0.99999999954344 RARS2 1 GO:0098813 nuclear chromosome segregation 3/852 281/18722 0.999800196729763 0.99999999954344 P3H4/CTNNB1/CCNE1 3 GO:0071824 protein-DNA complex subunit organization 2/852 241/18722 0.999843383518561 0.99999999954344 SMYD3/TP53 2 GO:0007059 chromosome segregation 4/852 346/18722 0.999918993702001 0.99999999954344 P3H4/CTNNB1/ARL8B/CCNE1 4 GO:0000819 sister chromatid segregation 1/852 202/18722 0.999922126779586 0.99999999954344 CTNNB1 1 GO:0006364 rRNA processing 1/852 225/18722 0.999973656760013 0.99999999954344 DDX17 1 GO:0016072 rRNA metabolic process 1/852 236/18722 0.999984320549523 0.99999999954344 DDX17 1 GO:0042254 ribosome biogenesis 2/852 299/18722 0.99998763015808 0.99999999954344 RPS27L/DDX17 2 GO:0006302 double-strand break repair 1/852 251/18722 0.999992276219809 0.99999999954344 TP53 1 GO:0022613 ribonucleoprotein complex biogenesis 4/852 463/18722 0.999999281316747 0.99999999954344 RPS27L/SRSF6/DDX17/EIF4B 4 GO:0034660 ncRNA metabolic process 4/852 485/18722 0.999999712158933 0.99999999954344 SMAD3/RARS2/DDX17/KCNQ1OT1 4 GO:0034470 ncRNA processing 2/852 395/18722 0.999999830439783 0.99999999954344 SMAD3/DDX17 2 GO:0007608 sensory perception of smell 1/852 456/18722 0.99999999954344 0.99999999954344 NAV2 1