ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0008094	ATP-dependent activity, acting on DNA	37/897	111/18367	1.80700226829079e-21	1.56667096660812e-18	TOP2A/HELLS/SMC3/MCM3/ATAD5/RFC3/MCM7/SMARCA2/MCM6/RAD51C/MCM4/MSH6/RFC1/RAD51/POLQ/MSH2/BLM/XRCC2/MCM2/RFC4/TTF2/MCM8/RFC2/MCM5/SMARCA1/G3BP1/DHX9/SMARCA4/ASCC3/CHD4/RBBP4/BPTF/RAD50/SMARCA5/ATRX/XRCC5/XRCC6	37
GO:0140097	catalytic activity, acting on DNA	48/897	229/18367	5.51593693136043e-18	2.39115865974475e-15	TOP2A/HELLS/PCNA/SMC3/MCM3/ATAD5/RFC3/MCM7/SMARCA2/MCM6/FEN1/LIG1/RAD51C/MCM4/MSH6/RFC1/RAD51/POLQ/POLD3/MSH2/BLM/XRCC2/MCM2/RFC4/ZGRF1/TTF2/POLA1/MCM8/REV1/RFC2/MCM5/DNMT1/SMARCA1/DICER1/UNG/G3BP1/DNMT3A/DHX9/SMARCA4/ASCC3/CHD4/RBBP4/BPTF/RAD50/SMARCA5/ATRX/XRCC5/XRCC6	48
GO:0003697	single-stranded DNA binding	32/897	123/18367	3.09813438262708e-15	8.95360836579228e-13	HMGB2/SMC4/HMGB1/BRCA2/NUCKS1/SMC2/MCM3/MCM7/RPA3/MCM6/RAD51AP1/MCM4/RAD51/MCM10/MSH2/BLM/MCM2/POLA1/SMC6/MCM8/MYEF2/RPA1/MCM5/SMARCA1/HNRNPA2B1/LRPPRC/DHX9/HNRNPU/RAD50/HSPD1/PURA/RAD23B	32
GO:0042393	histone binding	45/897	244/18367	9.32352517621597e-15	2.02087408194481e-12	NASP/DEK/CKS2/ATAD2/CKS1B/CBX5/SMARCA2/SUZ12/BAZ1B/DNAJC9/NCAPD2/ANP32E/IPO7/NCAPD3/MSH6/SSRP1/VRK1/PHIP/HAT1/ASF1B/MCM2/HJURP/NCAPG2/RNF168/NAP1L1/MORC4/IPO9/MTF2/SMARCC1/YEATS4/BRD7/SET/SMARCA4/TBL1X/TRIM24/RBBP4/BPTF/SMARCA5/FMR1/RBBP7/ANP32B/BRD4/ATRX/NAP1L4/CTSL	45
GO:0017116	single-stranded DNA helicase activity	13/897	23/18367	5.9927528471223e-12	1.03914334369101e-09	MCM3/RFC3/MCM7/MCM6/MCM4/RAD51/POLQ/MCM2/RFC4/MCM8/RFC2/MCM5/DHX9	13
GO:0003678	DNA helicase activity	21/897	72/18367	1.66928532119568e-11	2.33777756022889e-09	MCM3/RFC3/MCM7/MCM6/MCM4/RAD51/POLQ/BLM/MCM2/RFC4/MCM8/RFC2/MCM5/G3BP1/DHX9/ASCC3/CHD4/RAD50/ATRX/XRCC5/XRCC6	21
GO:0004386	helicase activity	31/897	156/18367	1.8874789990314e-11	2.33777756022889e-09	HELLS/MCM3/RFC3/MCM7/SMARCA2/MCM6/MCM4/RAD51/POLQ/BLM/MCM2/RFC4/ZGRF1/TTF2/MCM8/RFC2/MCM5/SMARCA1/DICER1/G3BP1/DHX9/SMARCA4/ASCC3/CHD4/DHX15/RAD50/SMARCA5/ATRX/DDX17/XRCC5/XRCC6	31
GO:0008022	protein C-terminus binding	33/897	189/18367	1.60170656424996e-10	1.55267675278741e-08	CENPF/TOP2A/MKI67/PCNA/BRCA2/MAD2L1/CDC20/BCAM/DST/TOPBP1/RAD51/GPSM2/MSH2/ITGB3BP/MDC1/MPDZ/DLG1/CEP135/YAP1/HIC2/AGO2/PPP1R9A/SAE1/YEATS4/FBLN1/MYO1C/TBL1X/ID1/CD2AP/PRRC2C/XRCC5/XRCC6/NCL	33
GO:0045296	cadherin binding	46/897	332/18367	1.61177517590388e-10	1.55267675278741e-08	ITGA6/DIAPH3/ANLN/CDH1/TMPO/EGFR/CCNB2/ITGB1/NOP56/SPTBN1/CKAP5/ANK3/DLG1/RANBP1/PAICS/CD46/PTPRM/SNX5/DOCK9/RDX/PKN2/VCL/PDLIM1/CTNND1/IQGAP1/MACF1/MPP7/SLK/HSPA5/ARGLU1/CTNNAL1/RAN/LARP1/STK24/KIF5B/ASAP1/CALD1/SERBP1/CD2AP/LIMA1/AHNAK/KTN1/HSPA8/RTN4/BSG/HSP90AB1	46
GO:0015631	tubulin binding	48/897	375/18367	9.90144139075414e-10	8.58454968578384e-08	CENPF/NUSAP1/STMN1/PRC1/TPX2/GTSE1/BIRC5/BRCA2/KIF23/KIF20B/CENPE/SMC3/DLGAP5/DAG1/BRCA1/KIF11/KIF4A/RACGAP1/GJA1/PLK1/DST/KIF22/KIF2C/CKAP5/KIF14/CEP295/CENPJ/KIF18A/KIFC1/CDK5RAP2/GAS2L3/KIF20A/HAUS8/KIF15/TPR/SKA2/KNSTRN/GPAA1/CEP57/LRPPRC/SETD2/CAMSAP2/CLIP1/MACF1/KIF5B/FMR1/CCT5/CACYBP	48
GO:0003684	damaged DNA binding	18/897	68/18367	2.66329984490405e-09	2.09916451411983e-07	HMGB2/HMGB1/PCNA/RPA3/BRCA1/FEN1/MSH6/POLQ/MSH2/BLM/SMC6/RPA1/REV1/UNG/XRCC5/XRCC6/DDB1/RAD23B	18
GO:0016887	ATP hydrolysis activity	38/897	272/18367	5.05015183056954e-09	3.64873469758649e-07	KIF23/KIF20B/ATAD2/MCM3/ATP2B1/MCM7/MCM6/HSP90AA1/MCM4/KIF22/KIF2C/ATP1A1/KIF14/BLM/MCM2/KIF18A/KIFC1/KIF20A/KIF15/FIGNL1/MCM8/ATP13A3/ATP2A2/MCM5/G3BP1/DHX9/ASCC3/CHD4/DHX15/HSPA5/SMARCA5/HSPD1/KIF5B/HSPA9/ATRX/DDX17/RHOBTB3/HSPA8	38
GO:0008017	microtubule binding	36/897	271/18367	4.79867509420461e-08	3.20034715898107e-06	CENPF/NUSAP1/PRC1/TPX2/GTSE1/BIRC5/KIF23/KIF20B/CENPE/DLGAP5/KIF11/KIF4A/RACGAP1/PLK1/DST/KIF22/KIF2C/CKAP5/KIF14/CEP295/KIF18A/KIFC1/CDK5RAP2/GAS2L3/KIF20A/HAUS8/KIF15/SKA2/KNSTRN/CEP57/LRPPRC/CAMSAP2/CLIP1/MACF1/KIF5B/FMR1	36
GO:0031491	nucleosome binding	16/897	71/18367	2.34061989829057e-07	1.44951246558423e-05	HMGN2/HP1BP3/SUPT16H/SSRP1/VRK1/PARP2/RNF168/SMARCC1/SMARCA1/SMARCA4/CHD4/RBBP4/SMARCA5/HDAC2/NAP1L4/HMGN1	16
GO:0070182	DNA polymerase binding	9/897	22/18367	4.24846220147628e-07	2.35707915525057e-05	HMGB1/PCNA/FANCI/HSP90AA1/FANCD2/CDT1/RAD51/SMARCA4/HSP90AB1	9
GO:0051082	unfolded protein binding	21/897	122/18367	4.34985772595262e-07	2.35707915525057e-05	TUBB4B/HSP90B1/HSP90AA1/LMAN1/CHAF1A/SRSF10/HSPA5/AFG3L2/CANX/CALR/HSPD1/SERPINH1/HSPA9/DNAJB11/NAP1L4/CCT5/HSPA8/CCT6A/CCT2/CCT4/HSP90AB1	21
GO:0000217	DNA secondary structure binding	11/897	36/18367	6.91841266173195e-07	3.5283904574833e-05	HMGB2/HMGB1/CLSPN/RAD51AP1/RAD51C/MSH6/MSH2/BLM/XRCC2/HNRNPD/HMGA1	11
GO:0003777	microtubule motor activity	15/897	69/18367	9.10800242465637e-07	4.38702116787615e-05	KIF23/KIF20B/CENPE/SMC3/KIF11/KIF4A/KIF22/KIF2C/KIF14/KIF18A/KIFC1/KIF20A/KIF15/DYNC1H1/KIF5B	15
GO:0003688	DNA replication origin binding	7/897	16/18367	5.02419213926523e-06	0.000217798729237148	CDC6/MCM10/MCM2/POLA1/MCM5/DHX9/HSPD1	7
GO:0035173	histone kinase activity	7/897	16/18367	5.02419213926523e-06	0.000217798729237148	CDK1/AURKA/BAZ1B/AURKB/CHEK1/VRK1/CDK2	7
GO:0003712	transcription coregulator activity	47/897	489/18367	7.65318195331654e-06	0.000315967083501212	HMGB2/HMGB1/NUCKS1/FUS/GMNN/EZH2/SMARCA2/BRCA1/PSIP1/PTPN14/PAWR/CENPJ/CASP8AP2/TCERG1/CCND1/SRSF2/ACTN1/CCAR1/YAP1/SMARCC1/RERE/SF1/BRD7/BRD8/USP22/ASXL1/DNMT3A/DHX9/SMARCA4/TBL1X/HNRNPU/PDLIM1/TAF15/TRIM24/ZNF451/TRIM28/PA2G4/TRIP11/BRD4/MAGED1/BCLAF1/THRAP3/TLE4/NCOA3/DDX17/HMGA1/EID1	47
GO:0000400	four-way junction DNA binding	7/897	17/18367	8.18105817216087e-06	0.000322408065239249	HMGB2/HMGB1/RAD51C/MSH6/MSH2/BLM/XRCC2	7
GO:0140142	nucleocytoplasmic carrier activity	9/897	31/18367	1.15704416473805e-05	0.000436155343838212	KPNA2/KPNB1/XPO1/CSE1L/IPO5/RANBP17/IPO9/TNPO1/RAN	9
GO:0044183	protein folding chaperone	10/897	40/18367	1.63232106273794e-05	0.000589675983914081	CCDC47/HSPA5/CALR/HSPA9/CCT5/HSPA8/CCT6A/CCT2/CCT4/HSP90AB1	10
GO:0003713	transcription coactivator activity	29/897	262/18367	3.47328859208554e-05	0.00117261513588646	HMGB2/HMGB1/NUCKS1/FUS/SMARCA2/BRCA1/CENPJ/TCERG1/ACTN1/CCAR1/YAP1/SMARCC1/RERE/BRD7/BRD8/USP22/ASXL1/DHX9/SMARCA4/PDLIM1/TRIM24/TRIM28/TRIP11/BRD4/MAGED1/THRAP3/NCOA3/DDX17/HMGA1	29
GO:0140030	modification-dependent protein binding	21/897	160/18367	3.51649291038614e-05	0.00117261513588646	CBX5/AGL/SUZ12/NCAPD3/MSH6/PHIP/NCAPG2/RNF168/MORC4/MTF2/YEATS4/BRD7/SMARCA4/TRIM24/BPTF/HSPD1/FMR1/BRD4/PRPF8/ATRX/RAD23B	21
GO:0003774	cytoskeletal motor activity	17/897	114/18367	3.76749913492538e-05	0.00120978583332604	MYH10/KIF23/KIF20B/CENPE/SMC3/KIF11/KIF4A/KIF22/KIF2C/KIF14/KIF18A/KIFC1/KIF20A/KIF15/MYO1C/DYNC1H1/KIF5B	17
GO:0051020	GTPase binding	31/897	291/18367	3.97672212962513e-05	0.00123136360228035	DIAPH3/BIRC5/ECT2/KPNB1/IQGAP2/HSP90AA1/IPO7/XPO1/SPTBN1/CSE1L/CHML/EPS8/IPO5/EXPH5/RANBP17/KNTC1/RANBP1/ROCK2/IPO9/PPP1R9A/PKN2/MYO1C/TNPO1/GOLGA4/IQGAP1/RANBP2/TRIP11/TRIOBP/RHOBTB3/LSM2/RASA1	31
GO:0042162	telomeric DNA binding	9/897	36/18367	4.33571739835163e-05	0.00129622999461064	BLM/RPA1/HNRNPA2B1/HNRNPD/RAD50/PURA/XRCC5/XRCC6/NCL	9
GO:0043138	3'-5' DNA helicase activity	6/897	15/18367	4.56608704288752e-05	0.00131959915539449	MCM6/BLM/MCM2/MCM5/DHX9/ASCC3	6
GO:0003725	double-stranded RNA binding	13/897	74/18367	5.41371090819628e-05	0.00151409269593748	TUBA1B/HMGB1/TUBB4B/ACTN1/AGO2/DICER1/ILF3/DHX9/HNRNPU/DHX15/HSPD1/CLTC/HSP90AB1	13
GO:0005178	integrin binding	19/897	144/18367	7.59750903627642e-05	0.00205845010451614	HMGB1/LAMB1/FBN1/EGFR/ITGAV/ITGB1/LAMA5/ITGB4/DST/ITGB8/EMP2/UTRN/ACTN1/TSPAN4/FERMT1/ITGB5/FBLN1/P4HB/CALR	19
GO:0044389	ubiquitin-like protein ligase binding	32/897	316/18367	8.01337886735623e-05	0.00210533317515086	TUBB/TUBA1B/CCNB1/UBE2C/UBE2T/EGFR/AURKA/BRCA1/HSP90AA1/SMC6/PSMD1/FZD5/SLF2/FZD6/NAE1/LRPPRC/VCL/HSPA5/TRIM28/PA2G4/CALR/CUL1/HSPD1/HSPA9/CACYBP/TRIOBP/HSPA8/XRCC5/CCT2/RTN4/SLC25A5/HSP90AB1	32
GO:0008574	plus-end-directed microtubule motor activity	6/897	17/18367	0.000103785687891994	0.00264653504124585	KIF20B/CENPE/KIF11/KIF14/KIF18A/KIF5B	6
GO:0140658	ATP-dependent chromatin remodeler activity	8/897	32/18367	0.00011571946664584	0.00286653650234123	HELLS/SMARCA2/TTF2/SMARCA1/SMARCA4/CHD4/SMARCA5/ATRX	8
GO:0031625	ubiquitin protein ligase binding	30/897	297/18367	0.000138440578260031	0.00333411059309575	TUBB/TUBA1B/UBE2T/EGFR/AURKA/BRCA1/HSP90AA1/SMC6/PSMD1/FZD5/SLF2/FZD6/NAE1/LRPPRC/VCL/HSPA5/TRIM28/PA2G4/CALR/CUL1/HSPD1/HSPA9/CACYBP/TRIOBP/HSPA8/XRCC5/CCT2/RTN4/SLC25A5/HSP90AB1	30
GO:0031267	small GTPase binding	27/897	259/18367	0.000175471096520441	0.00411171461306007	DIAPH3/BIRC5/ECT2/KPNB1/IQGAP2/IPO7/XPO1/CSE1L/CHML/EPS8/IPO5/EXPH5/RANBP17/KNTC1/RANBP1/ROCK2/IPO9/PKN2/MYO1C/TNPO1/GOLGA4/IQGAP1/RANBP2/TRIP11/TRIOBP/RHOBTB3/LSM2	27
GO:0070063	RNA polymerase binding	12/897	73/18367	0.000200729899639796	0.00457981113125536	BRCA1/TCERG1/ZNF326/AGO2/PKN2/NEDD4/DHX9/HNRNPU/ANP32B/BRD4/PABPN1/NCOA3	12
GO:0048027	mRNA 5'-UTR binding	7/897	27/18367	0.000243260116065589	0.00538271477476456	MYH10/IGF2BP3/LARP1/SYNCRIP/FMR1/CCT5/NCL	7
GO:0003779	actin binding	39/897	440/18367	0.000248565027882257	0.00538271477476456	SYNE2/DIAPH3/MYH10/ANLN/EGFR/DAG1/IQGAP2/ITGB1/SPTBN1/DST/PAWR/EPS8/KIF18A/GAS2L3/SVIL/YWHAH/SLC6A4/UTRN/ACTN1/PHACTR2/FERMT1/COBL/PPP1R9A/PALLD/RDX/MYO1C/VCL/HNRNPU/PDLIM1/IQGAP1/P4HB/MACF1/ADD3/CTNNAL1/TRPM7/EPB41L3/CALD1/LIMA1/TRIOBP	39
GO:0031994	insulin-like growth factor I binding	5/897	13/18367	0.000254545912070758	0.00538271477476456	LRP2/ITGA6/ITGAV/ITGB4/IGF1R	5
GO:0044325	transmembrane transporter binding	17/897	133/18367	0.000262388903100969	0.00541645664258428	TCAF1/ANK3/PKD2/DLG1/YWHAH/CALM2/ATP2A2/SLC5A3/ACTN1/PPP1R9A/USP10/AKAP9/YES1/GOPC/FMR1/PRKCSH/HSP90AB1	17
GO:0097718	disordered domain specific binding	8/897	36/18367	0.000279921047368395	0.00564398948996275	RRM1/HSP90AA1/GJA5/GJA1/CALM2/NCOA3/CLTC/HSP90AB1	8
GO:0003714	transcription corepressor activity	21/897	187/18367	0.000329742012335297	0.00649741647033414	GMNN/EZH2/PAWR/CASP8AP2/TCERG1/CCND1/SRSF2/CCAR1/YAP1/RERE/SF1/BRD7/DNMT3A/SMARCA4/TBL1X/HNRNPU/ZNF451/TRIM28/PA2G4/TLE4/EID1	21
GO:0051010	microtubule plus-end binding	6/897	21/18367	0.000384694001080853	0.00709637657312977	DST/KIF2C/CKAP5/KIF18A/KNSTRN/CLIP1	6
GO:0070577	lysine-acetylated histone binding	6/897	21/18367	0.000384694001080853	0.00709637657312977	PHIP/YEATS4/BRD7/SMARCA4/TRIM24/BRD4	6
GO:0140033	acetylation-dependent protein binding	6/897	21/18367	0.000384694001080853	0.00709637657312977	PHIP/YEATS4/BRD7/SMARCA4/TRIM24/BRD4	6
GO:1990825	sequence-specific mRNA binding	5/897	15/18367	0.000547296063234427	0.00988553514217184	TYMS/DHFR/SRSF4/DHX9/FMR1	5
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	9/897	50/18367	0.000624979204364422	0.0110583055139582	CCNB1/CCNA2/CKS2/CKS1B/CCNB2/CCNF/CCND1/CDKN2A/CCNE1	9
GO:0140104	molecular carrier activity	11/897	73/18367	0.000786567337300546	0.0136390776287915	KPNA2/KPNB1/XPO1/CSE1L/IPO5/RANBP17/IPO9/TNPO1/EMC1/RAN/HSPA8	11
GO:0070840	dynein complex binding	6/897	24/18367	0.000841610537496684	0.0143073791374436	CENPF/SMC3/GPSM2/TPR/ATMIN/FMR1	6
GO:0003727	single-stranded RNA binding	12/897	87/18367	0.0010369752752224	0.017289568531112	HMGB1/L1TD1/MSI2/AGO2/ILF3/DHX9/HNRNPU/KHDRBS1/FMR1/HNRNPH1/HNRNPF/HNRNPDL	12
GO:0001618	virus receptor activity	11/897	76/18367	0.00110857858291634	0.0181346722903484	CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/CD46/ITGB5/SLC1A5/SIVA1/BSG	11
GO:0140272	exogenous protein binding	11/897	77/18367	0.00123741900209632	0.0198674495336576	CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/CD46/ITGB5/SLC1A5/SIVA1/BSG	11
GO:0005049	nuclear export signal receptor activity	4/897	11/18367	0.00141496418038062	0.0207927787184746	XPO1/CSE1L/RANBP17/RAN	4
GO:0032404	mismatch repair complex binding	4/897	11/18367	0.00141496418038062	0.0207927787184746	PCNA/MSH6/MSH2/MCM8	4
GO:0035197	siRNA binding	4/897	11/18367	0.00141496418038062	0.0207927787184746	AGO2/DICER1/DHX9/FMR1	4
GO:0097493	structural molecule activity conferring elasticity	4/897	11/18367	0.00141496418038062	0.0207927787184746	FBN2/FBN1/LAMC1/AHNAK	4
GO:1990226	histone methyltransferase binding	4/897	11/18367	0.00141496418038062	0.0207927787184746	NOP56/CBX1/CBX3/HSP90AB1	4
GO:0031490	chromatin DNA binding	13/897	103/18367	0.00150693065226783	0.0217751479252701	HMGN2/EZH2/SUZ12/SMARCC1/CTCF/DHX9/SMARCA4/HNRNPU/CHD4/RBBP4/HDAC2/ZFX/HMGN1	13
GO:0061980	regulatory RNA binding	8/897	46/18367	0.00156793582393454	0.0222852517926434	SOX4/AGO2/DICER1/KCNQ1OT1/HNRNPA2B1/DHX9/PUM1/FMR1	8
GO:0017154	semaphorin receptor activity	4/897	12/18367	0.00204084873607478	0.0285389653899489	MET/NRP2/NRP1/PLXNB1	4
GO:0061608	nuclear import signal receptor activity	5/897	20/18367	0.00230523383454899	0.0317244084849838	KPNA2/KPNB1/IPO5/IPO9/TNPO1	5
GO:0005520	insulin-like growth factor binding	6/897	29/18367	0.00241152650256899	0.0326686480894892	LRP2/ITGA6/ITGAV/ITGB4/IGF1R/CRIM1	6
GO:0035064	methylated histone binding	10/897	73/18367	0.0027940625371499	0.0367038215107418	CBX5/SUZ12/NCAPD3/MSH6/NCAPG2/MORC4/MTF2/BPTF/FMR1/ATRX	10
GO:0140034	methylation-dependent protein binding	10/897	73/18367	0.0027940625371499	0.0367038215107418	CBX5/SUZ12/NCAPD3/MSH6/NCAPG2/MORC4/MTF2/BPTF/FMR1/ATRX	10
GO:0140416	transcription regulator inhibitor activity	5/897	21/18367	0.00290540253250779	0.0374737668155684	NCAPG2/ID4/TAF3/ID1/PURA	5
GO:0031492	nucleosomal DNA binding	7/897	40/18367	0.00293911896592694	0.0374737668155684	HMGN2/SMARCC1/SMARCA4/CHD4/RBBP4/HDAC2/HMGN1	7
GO:0042826	histone deacetylase binding	14/897	127/18367	0.0036546813994917	0.0459218662805696	TOP2A/KPNA2/GMNN/CDC20/PARP1/HSP90AA1/CCND1/PKN2/SFPQ/HNRNPD/CHD4/RBBP4/HDAC2/HSP90AB1	14
GO:0044548	S100 protein binding	4/897	14/18367	0.0038166318102986	0.047271711136127	ATP2A2/IQGAP1/AHNAK/CACYBP	4
GO:0019199	transmembrane receptor protein kinase activity	15/897	143/18367	0.00430251649802232	0.0525391803350049	EFEMP1/MET/EGFR/NRP2/PBK/BAZ1B/WEE1/NRP1/TTK/IGF1R/MELK/LTBP1/CRIM1/TGFBR3/YES1	15
GO:0005200	structural constituent of cytoskeleton	12/897	103/18367	0.00439792747624851	0.0529583766931592	TUBB/TUBA1B/TUBA1C/DSP/TUBB4B/SPTBN1/ANK3/TUBG1/YEATS4/ADD3/EPB41L3/CD2AP	12
GO:0042813	Wnt-activated receptor activity	4/897	15/18367	0.0050054811728674	0.059448659957206	LRP5/FZD5/FZD6/RYK	4
GO:0035198	miRNA binding	6/897	34/18367	0.00554956931264666	0.0650199539738467	SOX4/AGO2/KCNQ1OT1/HNRNPA2B1/PUM1/FMR1	6
GO:0017070	U6 snRNA binding	4/897	16/18367	0.00641923178731599	0.0742063194613729	LSM8/LSM4/PRPF8/LSM2	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	13/897	124/18367	0.00759212804298996	0.0860294916592328	EFEMP1/MET/EGFR/NRP2/PBK/BAZ1B/WEE1/NRP1/TTK/IGF1R/MELK/CRIM1/YES1	13
GO:0098631	cell adhesion mediator activity	8/897	59/18367	0.00764045081633325	0.0860294916592328	DSP/DSG2/ITGB1/BCAM/DSC2/PALLD/PDLIM1/BSG	8
GO:0034185	apolipoprotein binding	4/897	17/18367	0.00807456028181305	0.0886157438523027	VLDLR/CANX/HSPD1/LRP1	4
GO:0070628	proteasome binding	4/897	17/18367	0.00807456028181305	0.0886157438523027	ID1/USP14/PSMD14/RAD23B	4
GO:0015026	coreceptor activity	7/897	48/18367	0.00828766860278415	0.0898176084826733	ITGAV/ITGB1/NRP1/LRP5/RYK/TGFBR3/LRP1	7
GO:0008301	DNA binding, bending	4/897	18/18367	0.00998678364492473	0.106895573088268	TOP2A/HMGB2/HMGB1/TFAM	4
GO:0051015	actin filament binding	19/897	217/18367	0.0101739965298845	0.107239923111592	SYNE2/MYH10/EGFR/IQGAP2/SPTBN1/GAS2L3/SVIL/SLC6A4/UTRN/ACTN1/FERMT1/PPP1R9A/MYO1C/IQGAP1/MACF1/ADD3/CTNNAL1/LIMA1/TRIOBP	19
GO:0001968	fibronectin binding	5/897	28/18367	0.0105818543409387	0.107239923111592	ITGAV/ITGB1/FBLN1/CCDC80/CTSL	5
GO:0008187	poly-pyrimidine tract binding	5/897	28/18367	0.0105818543409387	0.107239923111592	MSI2/HNRNPU/KHDRBS1/FMR1/HNRNPH1	5
GO:0043236	laminin binding	5/897	28/18367	0.0105818543409387	0.107239923111592	ITGA6/DAG1/ITGB1/BCAM/TINAGL1	5
GO:0008641	ubiquitin-like modifier activating enzyme activity	3/897	10/18367	0.0107610995509902	0.107239923111592	NAE1/SAE1/UBA2	3
GO:0032356	oxidized DNA binding	3/897	10/18367	0.0107610995509902	0.107239923111592	MSH6/MSH2/BLM	3
GO:0019887	protein kinase regulator activity	18/897	204/18367	0.0112867675158037	0.111200311775021	CCNB1/TPX2/HMGB1/CCNA2/CKS2/CKS1B/CCNB2/DBF4/NCAPG2/CCNF/CIT/CCND1/CALM2/CDKN2A/IQGAP1/CCNE1/CD24/HSP90AB1	18
GO:0001221	transcription coregulator binding	9/897	78/18367	0.0135551598052352	0.128764736902402	EZH2/SUZ12/CIT/MTF2/TFAM/CTCF/SMARCA4/CHD4/CBX3	9
GO:0017147	Wnt-protein binding	5/897	30/18367	0.0141624581154681	0.128764736902402	WLS/LRP5/FZD5/FZD6/RYK	5
GO:0010485	H4 histone acetyltransferase activity	3/897	11/18367	0.0142659003149688	0.128764736902402	BRCA2/HAT1/USP22	3
GO:0022889	serine transmembrane transporter activity	3/897	11/18367	0.0142659003149688	0.128764736902402	SFXN1/SLC38A2/SLC1A5	3
GO:0047429	nucleoside-triphosphate diphosphatase activity	3/897	11/18367	0.0142659003149688	0.128764736902402	DUT/NUDT15/DHX9	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/897	11/18367	0.0142659003149688	0.128764736902402	DSP/DSG2/DSC2	3
GO:0043021	ribonucleoprotein complex binding	14/897	149/18367	0.0144026999669936	0.128764736902402	CBX5/RPN2/EZH2/CKAP5/UNG/DHX9/CCDC47/HNRNPU/SNRPD1/HSPA5/LARP1/FMR1/SERBP1/SNRPG	14
GO:0003756	protein disulfide isomerase activity	4/897	20/18367	0.0146359114397562	0.128764736902402	PDIA6/PDIA4/PDIA3/P4HB	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4/897	20/18367	0.0146359114397562	0.128764736902402	PDIA6/PDIA4/PDIA3/P4HB	4
GO:0030506	ankyrin binding	4/897	20/18367	0.0146359114397562	0.128764736902402	CDH1/SPTBN1/ATP1A1/NRCAM	4
GO:0002039	p53 binding	8/897	66/18367	0.0147032398539075	0.128764736902402	BLM/BRD7/TAF3/SMARCA4/TRIM24/USP10/HSPD1/BRD4	8
GO:0004713	protein tyrosine kinase activity	13/897	136/18367	0.0157601689571691	0.136640664858656	EFEMP1/MET/EGFR/NRP2/PBK/BAZ1B/WEE1/NRP1/TTK/IGF1R/MELK/CRIM1/YES1	13
GO:0043015	gamma-tubulin binding	5/897	31/18367	0.0162244679406486	0.139273403015271	BRCA2/RACGAP1/CENPJ/CDK5RAP2/CEP57	5
GO:0005080	protein kinase C binding	7/897	55/18367	0.017046024939822	0.144654385989694	TOP2A/DSP/ITGAV/SRSF2/HINT1/PARD6B/PRKCSH	7
GO:0015662	P-type ion transporter activity	4/897	21/18367	0.0173960311826382	0.144654385989694	ATP2B1/ATP1A1/ATP2A2/ATP1B3	4
GO:0140358	P-type transmembrane transporter activity	4/897	21/18367	0.0173960311826382	0.144654385989694	ATP2B1/ATP1A1/ATP2A2/ATP1B3	4
GO:0000340	RNA 7-methylguanosine cap binding	3/897	12/18367	0.0183409175079335	0.144654385989694	AGO2/NCBP3/LARP1	3
GO:0005095	GTPase inhibitor activity	3/897	12/18367	0.0183409175079335	0.144654385989694	IQGAP2/IPO5/IQGAP1	3
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	3/897	12/18367	0.0183409175079335	0.144654385989694	CDK1/CDK6/BRD4	3
GO:0017166	vinculin binding	3/897	12/18367	0.0183409175079335	0.144654385989694	DAG1/UTRN/ACTN1	3
GO:0043047	single-stranded telomeric DNA binding	3/897	12/18367	0.0183409175079335	0.144654385989694	RPA1/HNRNPA2B1/RAD50	3
GO:0140297	DNA-binding transcription factor binding	29/897	394/18367	0.0186358969649392	0.144654385989694	CENPF/HMGB1/PCNA/FUS/CBX5/GMNN/PARP1/NCAPG2/TCERG1/YWHAH/KLF5/YAP1/CDKN2A/BRD8/ASXL1/DHX9/SMARCA4/TRIM24/CHD4/CNOT1/CALR/PURA/HDAC2/RBPJ/THRAP3/TLE4/NCOA3/HMGA1/PTMA	29
GO:0030374	nuclear receptor coactivator activity	7/897	56/18367	0.0186866104162004	0.144654385989694	ACTN1/CCAR1/BRD8/USP22/THRAP3/NCOA3/HMGA1	7
GO:0050840	extracellular matrix binding	7/897	56/18367	0.0186866104162004	0.144654385989694	ITGA6/DAG1/ADGRG1/ITGAV/ITGB1/BCAM/TINAGL1	7
GO:0032182	ubiquitin-like protein binding	11/897	111/18367	0.0197591623837817	0.151603484838396	TOP2A/CKS2/CKS1B/N4BP2/BUB3/CASP8AP2/RNF168/NEDD4/UBA2/SERBP1/RAD23B	11
GO:0019838	growth factor binding	13/897	141/18367	0.0206686956814428	0.157190869787815	LRP2/ITGA6/EGFR/NRP2/ITGAV/NRP1/ITGB4/IGF1R/LTBP1/CRIM1/CEP57/GLG1/TGFBR3	13
GO:0030165	PDZ domain binding	9/897	84/18367	0.0211749521250076	0.159640726020709	ATP2B1/CADM1/GJA1/KIF14/CIT/ADRB1/CRIM1/TGFBR3/PLEKHA1	9
GO:0005201	extracellular matrix structural constituent	15/897	172/18367	0.0215061375301514	0.160739838264149	FBN2/COL14A1/LAMB1/EFEMP1/FBN1/LAMC1/LAMA5/COL4A2/FRAS1/LTBP1/COL5A2/FBLN1/COL21A1/VWA1/TINAGL1	15
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	3/897	13/18367	0.0229927644296239	0.170382280004136	CCNB1/CKS2/CKS1B	3
GO:0017134	fibroblast growth factor binding	4/897	23/18367	0.0238338556602029	0.175118244554203	ITGAV/CEP57/GLG1/TGFBR3	4
GO:0016922	nuclear receptor binding	13/897	144/18367	0.0241163959055875	0.17570517016928	PCNA/FUS/PARP1/YWHAH/BRD8/ASXL1/SMARCA4/TRIM24/CNOT1/CALR/THRAP3/NCOA3/HMGA1	13
GO:0030983	mismatched DNA binding	3/897	14/18367	0.028222618780349	0.202223227128617	PCNA/MSH6/MSH2	3
GO:0140666	annealing activity	3/897	14/18367	0.028222618780349	0.202223227128617	BLM/SMARCA1/FMR1	3
GO:0042805	actinin binding	5/897	36/18367	0.0295051422699385	0.209679986459317	DAG1/PKD2/PALLD/PDLIM1/CSRP2	5
GO:0106310	protein serine kinase activity	26/897	360/18367	0.0305090991638417	0.211972769346251	CDK1/PRKDC/AURKA/PBK/AURKB/TTK/PLK1/BUB1B/CHEK1/VRK1/BUB1/MELK/PKMYT1/NEK2/MASTL/CIT/NRK/ROCK2/SRPK1/PKN2/CDK6/CDK2/SLK/TRPM7/CAMK2G/STK24	26
GO:1990841	promoter-specific chromatin binding	7/897	62/18367	0.0308938219143488	0.211972769346251	EZH2/RBL1/DNMT1/DHX9/HNRNPU/TRIM28/HDAC2	7
GO:0043539	protein serine/threonine kinase activator activity	6/897	49/18367	0.031209535192679	0.211972769346251	CCNB1/CKS2/CKS1B/DBF4/CALM2/IQGAP1	6
GO:0098632	cell-cell adhesion mediator activity	6/897	49/18367	0.031209535192679	0.211972769346251	DSP/DSG2/DSC2/PALLD/PDLIM1/BSG	6
GO:0003887	DNA-directed DNA polymerase activity	4/897	25/18367	0.0315392009753938	0.211972769346251	POLQ/POLD3/POLA1/REV1	4
GO:0008266	poly(U) RNA binding	4/897	25/18367	0.0315392009753938	0.211972769346251	MSI2/KHDRBS1/FMR1/HNRNPH1	4
GO:0035925	mRNA 3'-UTR AU-rich region binding	4/897	25/18367	0.0315392009753938	0.211972769346251	EXOSC8/ILF3/HNRNPD/KHSRP	4
GO:0016758	hexosyltransferase activity	16/897	197/18367	0.0322768232236099	0.215261582575922	GALNT11/AGL/RPN2/FUT8/ALG10B/EXTL2/GCNT2/STT3B/GALNT18/TMTC3/DPY19L1/CHPF/MTAP/HEXB/C1GALT1/RPN1	16
GO:0005041	low-density lipoprotein particle receptor activity	3/897	15/18367	0.0340269031822194	0.217103964757836	LRP2/VLDLR/LRP1	3
GO:0032794	GTPase activating protein binding	3/897	15/18367	0.0340269031822194	0.217103964757836	TUBB/CDH1/PLXNB1	3
GO:0051371	muscle alpha-actinin binding	3/897	15/18367	0.0340269031822194	0.217103964757836	PKD2/PALLD/PDLIM1	3
GO:0098847	sequence-specific single stranded DNA binding	3/897	15/18367	0.0340269031822194	0.217103964757836	RPA1/HNRNPA2B1/RAD50	3
GO:0000993	RNA polymerase II complex binding	6/897	50/18367	0.0340555238835821	0.217103964757836	ZNF326/AGO2/DHX9/HNRNPU/BRD4/NCOA3	6
GO:0015932	nucleobase-containing compound transmembrane transporter activity	6/897	50/18367	0.0340555238835821	0.217103964757836	SLC29A1/SLC35B4/SLC25A36/HNRNPA3/SLC35D1/SLC25A5	6
GO:0030371	translation repressor activity	4/897	26/18367	0.0358781274570795	0.225408235545565	TYMS/DHFR/FMR1/PURA	4
GO:0042974	retinoic acid receptor binding	4/897	26/18367	0.0358781274570795	0.225408235545565	FUS/ASXL1/CNOT1/HMGA1	4
GO:0004520	endodeoxyribonuclease activity	5/897	38/18367	0.0362957827841227	0.226391681106722	FEN1/RAD51C/ZGRF1/DICER1/RAD50	5
GO:0019207	kinase regulator activity	18/897	233/18367	0.037181208275502	0.230257911249002	CCNB1/TPX2/HMGB1/CCNA2/CKS2/CKS1B/CCNB2/DBF4/NCAPG2/CCNF/CIT/CCND1/CALM2/CDKN2A/IQGAP1/CCNE1/CD24/HSP90AB1	18
GO:0003730	mRNA 3'-UTR binding	16/897	201/18367	0.0377732259571615	0.230734763112108	FUS/HNRNPR/EXOSC8/IGF2BP3/ILF3/CARHSP1/HNRNPA2B1/HNRNPD/HNRNPU/LARP1/PUM1/KHSRP/FMR1/SERBP1/RNPS1/CCT5	16
GO:0008514	organic anion transmembrane transporter activity	15/897	185/18367	0.037790468698869	0.230734763112108	SLC29A1/SLC38A1/GJA1/SLC35B4/SFXN1/SLC16A1/SLC26A2/SLC16A12/SLC35D1/SLC38A2/SLC1A5/SLC25A1/SLC2A1/SLC13A3/SLC25A5	15
GO:0004674	protein serine/threonine kinase activity	27/897	386/18367	0.0392549020365381	0.234345411339116	CDK1/PRKDC/EGFR/AURKA/PBK/AURKB/TTK/PLK1/CHEK1/VRK1/MELK/PKMYT1/NEK2/MASTL/CIT/LTBP1/NRK/ROCK2/SRPK1/PKN2/CDK6/CDK2/SLK/TGFBR3/CAMK2G/STK24/BRD4	27
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	5/897	39/18367	0.0400223027117324	0.234345411339116	IQGAP2/RACGAP1/PARD3/IQGAP1/ASAP1	5
GO:0000900	translation repressor activity, mRNA regulatory element binding	3/897	16/18367	0.040397904273351	0.234345411339116	TYMS/DHFR/PURA	3
GO:0005092	GDP-dissociation inhibitor activity	3/897	16/18367	0.040397904273351	0.234345411339116	CHML/GPSM2/RANBP1	3
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	3/897	16/18367	0.040397904273351	0.234345411339116	FEN1/ZGRF1/DICER1	3
GO:0032183	SUMO binding	3/897	16/18367	0.040397904273351	0.234345411339116	CASP8AP2/UBA2/SERBP1	3
GO:0008139	nuclear localization sequence binding	4/897	27/18367	0.0405441888129958	0.234345411339116	KPNA2/KPNB1/IPO5/TNPO1	4
GO:0051393	alpha-actinin binding	4/897	27/18367	0.0405441888129958	0.234345411339116	DAG1/PKD2/PALLD/PDLIM1	4
GO:0016757	glycosyltransferase activity	20/897	270/18367	0.0425047187841114	0.243199137986291	GALNT11/AGL/RPN2/PARP1/GXYLT1/PARP2/FUT8/ALG10B/EXTL2/GCNT2/PPAT/STT3B/GALNT18/TMTC3/DPY19L1/CHPF/MTAP/HEXB/C1GALT1/RPN1	20
GO:0047485	protein N-terminus binding	10/897	110/18367	0.0426369884358895	0.243199137986291	PARP1/ZWINT/CALM2/SMARCC1/SMARCA4/ID1/SRRM2/RBPJ/NCOA3/RPS21	10
GO:0015101	organic cation transmembrane transporter activity	4/897	28/18367	0.0455379112250053	0.254718509884384	SLC29A1/ATP13A3/SLC44A2/SLC44A1	4
GO:0017056	structural constituent of nuclear pore	4/897	28/18367	0.0455379112250053	0.254718509884384	NDC1/NUP155/NUP107/TPR	4
GO:0070325	lipoprotein particle receptor binding	4/897	28/18367	0.0455379112250053	0.254718509884384	HSP90B1/LRP1/LRPAP1/CLTC	4
GO:0008381	mechanosensitive ion channel activity	3/897	17/18367	0.0473243351286805	0.261338844309338	TMEM63A/TMC5/TMEM150C	3
GO:0070064	proline-rich region binding	3/897	17/18367	0.0473243351286805	0.261338844309338	CCND1/YAP1/NEDD4	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	5/897	41/18367	0.0481482276307697	0.264205780733401	SLC27A2/NAE1/SAE1/UBA2/ACSS1	5
GO:0051787	misfolded protein binding	4/897	29/18367	0.0508585360651769	0.275589692303177	HSPA5/HSPA9/DNAJB11/HSPA8	4
GO:0070717	poly-purine tract binding	4/897	29/18367	0.0508585360651769	0.275589692303177	HNRNPU/KHDRBS1/FMR1/HNRNPDL	4
GO:0015036	disulfide oxidoreductase activity	5/897	42/18367	0.0525500382043846	0.282986851696904	PDIA6/PDIA4/TMX1/PDIA3/P4HB	5
GO:0030228	lipoprotein particle receptor activity	3/897	18/18367	0.0547918454254317	0.291438834256744	LRP2/VLDLR/LRP1	3
GO:0070122	isopeptidase activity	3/897	18/18367	0.0547918454254317	0.291438834256744	PRPF8/PSMD7/PSMD14	3
GO:0046966	thyroid hormone receptor binding	4/897	30/18367	0.0565040865189783	0.298713676902159	FUS/BRD8/THRAP3/NCOA3	4
GO:0016504	peptidase activator activity	5/897	43/18367	0.0571783775117054	0.300446383652416	APP/CASP8AP2/FBLN1/PCOLCE2/PSMD14	5
GO:0030295	protein kinase activator activity	9/897	101/18367	0.0584790163829692	0.304404470086977	CCNB1/TPX2/HMGB1/CKS2/CKS1B/DBF4/CALM2/IQGAP1/CD24	9
GO:0043175	RNA polymerase core enzyme binding	6/897	57/18367	0.0586338483327856	0.304404470086977	ZNF326/AGO2/DHX9/HNRNPU/BRD4/NCOA3	6
GO:0000339	RNA cap binding	3/897	19/18367	0.0627834834579411	0.322090415136301	AGO2/NCBP3/LARP1	3
GO:0035613	RNA stem-loop binding	3/897	19/18367	0.0627834834579411	0.322090415136301	MYH10/DHX9/FMR1	3
GO:0008201	heparin binding	13/897	166/18367	0.0633003692725494	0.322831883290002	APLP2/FBN1/NRP2/APP/ADGRG1/BMP7/NRP1/FSTL1/ADAMTS1/CCDC80/TGFBR3/PCOLCE2/LRPAP1	13
GO:0004197	cysteine-type endopeptidase activity	10/897	119/18367	0.0659754825963812	0.334507271409722	USP1/CTSV/USP48/GPAA1/PDIA3/USP10/USP9X/USP14/USP47/CTSL	10
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	5/897	45/18367	0.0671131304647593	0.336738437138254	FEN1/RNASEH2A/ZGRF1/AGO2/DICER1	5
GO:0036002	pre-mRNA binding	6/897	59/18367	0.0671923294405052	0.336738437138254	SLBP/SRSF2/SF1/HNRNPU/PRPF8/TRA2B	6
GO:0005516	calmodulin binding	15/897	201/18367	0.0681304827180689	0.338703339770419	ASPM/MYH10/EGFR/ATP2B1/IQGAP2/SPTBN1/CDK5RAP2/MYO1C/CAMSAP2/IQGAP1/ADD3/EEA1/CAMK2G/CALD1/PHKB	15
GO:0030332	cyclin binding	4/897	32/18367	0.0687563873121036	0.338703339770419	CDK1/CDK6/CDK2/XRCC6	4
GO:0030515	snoRNA binding	4/897	32/18367	0.0687563873121036	0.338703339770419	PRKDC/NOP56/XRCC5/NUDT4	4
GO:0016018	cyclosporin A binding	3/897	20/18367	0.0712801138140913	0.34719021728549	PPIC/NKTR/PPIG	3
GO:0016500	protein-hormone receptor activity	3/897	20/18367	0.0712801138140913	0.34719021728549	LGR5/IGF1R/LGR4	3
GO:0000287	magnesium ion binding	16/897	221/18367	0.075568179519904	0.364440852519468	TOP2A/DUT/FEN1/WEE1/PLK1/MSH6/MSH2/PRIM1/FIGNL1/ENOSF1/SRPK1/PGP/RAN/UBA2/IDH2/RHEB	16
GO:0019829	ATPase-coupled cation transmembrane transporter activity	5/897	47/18367	0.0779440410937799	0.364440852519468	ATP2B1/ATP1A1/ATP13A3/ATP2A2/ATP1B3	5
GO:0019209	kinase activator activity	9/897	107/18367	0.0780740193498046	0.364440852519468	CCNB1/TPX2/HMGB1/CKS2/CKS1B/DBF4/CALM2/IQGAP1/CD24	9
GO:0051087	chaperone binding	9/897	107/18367	0.0780740193498046	0.364440852519468	LRP2/BIRC5/DNAJC9/ATP1A1/HSPA5/CALR/HSPD1/HSPA8/ERP29	9
GO:0043130	ubiquitin binding	8/897	92/18367	0.0803425590385756	0.364440852519468	TOP2A/CKS2/CKS1B/N4BP2/BUB3/RNF168/NEDD4/RAD23B	8
GO:0008376	acetylgalactosaminyltransferase activity	4/897	34/18367	0.082257338059213	0.364440852519468	GALNT11/EXTL2/GALNT18/CHPF	4
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	4/897	34/18367	0.082257338059213	0.364440852519468	FEN1/RNASEH2A/AGO2/DICER1	4
GO:0008234	cysteine-type peptidase activity	14/897	190/18367	0.08243599238726	0.364440852519468	GGH/USP1/CTSV/USP48/GPAA1/USP22/PDIA3/USP10/USP27X/USP9X/USP14/USP47/PSMD14/CTSL	14
GO:0004300	enoyl-CoA hydratase activity	2/897	10/18367	0.0826467170083702	0.364440852519468	ECHDC2/HADHA	2
GO:0004523	RNA-DNA hybrid ribonuclease activity	2/897	10/18367	0.0826467170083702	0.364440852519468	FEN1/RNASEH2A	2
GO:0008172	S-methyltransferase activity	2/897	10/18367	0.0826467170083702	0.364440852519468	MTR/DNMT3A	2
GO:0008190	eukaryotic initiation factor 4E binding	2/897	10/18367	0.0826467170083702	0.364440852519468	LARP1/EIF4G1	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/897	10/18367	0.0826467170083702	0.364440852519468	SLC35B4/SLC35D1	2
GO:0034511	U3 snoRNA binding	2/897	10/18367	0.0826467170083702	0.364440852519468	PRKDC/XRCC5	2
GO:0048256	flap endonuclease activity	2/897	10/18367	0.0826467170083702	0.364440852519468	FEN1/ZGRF1	2
GO:0050786	RAGE receptor binding	2/897	10/18367	0.0826467170083702	0.364440852519468	HMGB2/HMGB1	2
GO:0051880	G-quadruplex DNA binding	2/897	10/18367	0.0826467170083702	0.364440852519468	BLM/RAD50	2
GO:0098505	G-rich strand telomeric DNA binding	2/897	10/18367	0.0826467170083702	0.364440852519468	RPA1/HNRNPA2B1	2
GO:0046982	protein heterodimerization activity	22/897	328/18367	0.0828083597996945	0.364440852519468	TOP2A/SMC3/AURKA/TENM3/SMC1A/CENPW/ITGB1/BARD1/ATP1A1/TCOF1/CENPA/ADRB1/YWHAH/DGKD/NAE1/SAE1/TAF3/P4HB/RAN/LSM5/UBA2/FMR1	22
GO:0016853	isomerase activity	12/897	158/18367	0.0863368720643984	0.378050848888048	TOP2A/PDIA6/PDIA4/PPIC/ENOSF1/NKTR/DEGS1/PDIA3/P4HB/HSPD1/PPIG/ISYNA1	12
GO:0008242	omega peptidase activity	10/897	126/18367	0.088883875215423	0.379378540304828	GGH/USP1/USP48/USP22/USP10/USP27X/USP9X/USP14/USP47/PSMD14	10
GO:0008047	enzyme activator activity	9/897	110/18367	0.089207373574741	0.379378540304828	SUZ12/DBF4/RFC1/NCAPG2/CALM2/SAE1/CYB5B/XRCC5/DDOST	9
GO:0030674	protein-macromolecule adaptor activity	20/897	296/18367	0.0895195583381308	0.379378540304828	SYNE2/COL14A1/CBX5/POLD3/ANK3/TCOF1/EPS8/GAS2L3/NDC1/FRMD4A/DLG5/ICE1/IQGAP1/KHDRBS1/MPP7/RAD50/EPB41L3/ATP1B3/HSPA8/DDB1	20
GO:0016763	pentosyltransferase activity	5/897	49/18367	0.089654401605193	0.379378540304828	PARP1/GXYLT1/PARP2/PPAT/MTAP	5
GO:0005537	mannose binding	3/897	22/18367	0.0897031150663088	0.379378540304828	LMAN1/MANBA/BSG	3
GO:0008093	cytoskeletal anchor activity	3/897	22/18367	0.0897031150663088	0.379378540304828	ANK3/GAS2L3/EPB41L3	3
GO:0072349	modified amino acid transmembrane transporter activity	3/897	22/18367	0.0897031150663088	0.379378540304828	GJA1/SLC16A12/SLC13A3	3
GO:0016835	carbon-oxygen lyase activity	7/897	79/18367	0.0907642111166497	0.380157348010315	HACD3/POLQ/ENOSF1/ECHDC2/HADHA/XRCC5/XRCC6	7
GO:0046332	SMAD binding	7/897	79/18367	0.0907642111166497	0.380157348010315	PARP1/IPO7/COL5A2/TRIM33/TGFBR3/PURA/USP9X	7
GO:0060090	molecular adaptor activity	24/897	369/18367	0.0943480997099857	0.393268281002681	SYNE2/COL14A1/CBX5/POLD3/ANK3/TCOF1/EPS8/GAS2L3/NDC1/DLG1/FRMD4A/DLG5/ICE1/IQGAP1/KHDRBS1/MPP7/AKAP9/CNOT1/RAD50/EIF4G1/EPB41L3/ATP1B3/HSPA8/DDB1	24
GO:0034061	DNA polymerase activity	4/897	36/18367	0.0969546024203296	0.394555384476833	POLQ/POLD3/POLA1/REV1	4
GO:0061631	ubiquitin conjugating enzyme activity	4/897	36/18367	0.0969546024203296	0.394555384476833	UBE2C/UBE2S/UBE2T/UBE2G2	4
GO:0002162	dystroglycan binding	2/897	11/18367	0.0978424540513484	0.394555384476833	DAG1/VCL	2
GO:0035673	oligopeptide transmembrane transporter activity	2/897	11/18367	0.0978424540513484	0.394555384476833	GJA1/SLC13A3	2
GO:0046975	histone methyltransferase activity (H3-K36 specific)	2/897	11/18367	0.0978424540513484	0.394555384476833	SETD2/ASH1L	2
GO:0061665	SUMO ligase activity	2/897	11/18367	0.0978424540513484	0.394555384476833	ZNF451/RANBP2	2
GO:0099186	structural constituent of postsynapse	2/897	11/18367	0.0978424540513484	0.394555384476833	DLG1/ACTN1	2
GO:0008143	poly(A) binding	3/897	23/18367	0.0995835039772247	0.39604999058832	HNRNPU/KHDRBS1/HNRNPDL	3
GO:0030215	semaphorin receptor binding	3/897	23/18367	0.0995835039772247	0.39604999058832	SEMA6D/SEMA6A/PLXNB1	3
GO:0050750	low-density lipoprotein particle receptor binding	3/897	23/18367	0.0995835039772247	0.39604999058832	HSP90B1/LRPAP1/CLTC	3
GO:0004843	thiol-dependent deubiquitinase	9/897	113/18367	0.101231001109626	0.400763826310713	USP1/USP48/USP22/USP10/USP27X/USP9X/USP14/USP47/PSMD14	9
GO:0015035	protein-disulfide reductase activity	4/897	37/18367	0.104732013337769	0.410871744632785	PDIA6/PDIA4/PDIA3/P4HB	4
GO:0043531	ADP binding	4/897	37/18367	0.104732013337769	0.410871744632785	MYH10/MSH6/ATP1A1/MSH2	4
GO:0101005	deubiquitinase activity	9/897	114/18367	0.105435227070159	0.411767305719944	USP1/USP48/USP22/USP10/USP27X/USP9X/USP14/USP47/PSMD14	9
GO:0004867	serine-type endopeptidase inhibitor activity	8/897	98/18367	0.106119473043957	0.41258109026507	APLP2/ITIH5/APP/CRIM1/SPINT1/SPINT2/SERPINH1/SERPINF1	8
GO:0097110	scaffold protein binding	6/897	67/18367	0.108231431460161	0.418913620874818	DSP/HSP90AA1/TCOF1/CIT/DYNLL2/XRCC6	6
GO:0019789	SUMO transferase activity	3/897	24/18367	0.109877499391311	0.42152120341711	ZNF451/TRIM28/RANBP2	3
GO:0050431	transforming growth factor beta binding	3/897	24/18367	0.109877499391311	0.42152120341711	ITGAV/LTBP1/TGFBR3	3
GO:0015175	neutral amino acid transmembrane transporter activity	4/897	38/18367	0.112783334579374	0.423240232185181	SLC38A1/SFXN1/SLC38A2/SLC1A5	4
GO:0005024	transforming growth factor beta-activated receptor activity	2/897	12/18367	0.113742761360031	0.423240232185181	LTBP1/TGFBR3	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/897	12/18367	0.113742761360031	0.423240232185181	SLC35B4/SLC35D1	2
GO:0042975	peroxisome proliferator activated receptor binding	2/897	12/18367	0.113742761360031	0.423240232185181	ASXL1/HMGA1	2
GO:0045295	gamma-catenin binding	2/897	12/18367	0.113742761360031	0.423240232185181	CDH1/DSC3	2
GO:0061578	Lys63-specific deubiquitinase activity	2/897	12/18367	0.113742761360031	0.423240232185181	USP27X/PSMD14	2
GO:0070410	co-SMAD binding	2/897	12/18367	0.113742761360031	0.423240232185181	TRIM33/USP9X	2
GO:0017069	snRNA binding	5/897	53/18367	0.115609322113423	0.428347360138197	HNRNPU/LSM8/LSM4/PRPF8/LSM2	5
GO:0005518	collagen binding	6/897	69/18367	0.120132560271953	0.441851787799623	COL14A1/ADGRG1/ITGB1/SERPINH1/PCOLCE2/CTSL	6
GO:0004402	histone acetyltransferase activity	4/897	39/18367	0.121098881078533	0.441851787799623	BRCA2/HAT1/USP22/NCOA3	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/897	39/18367	0.121098881078533	0.441851787799623	UBE2C/UBE2S/UBE2T/UBE2G2	4
GO:0008013	beta-catenin binding	7/897	85/18367	0.121292647631269	0.441851787799623	CDH1/GJA1/KANK1/DLG5/VCL/TBL1X/CD2AP	7
GO:0001098	basal transcription machinery binding	6/897	70/18367	0.126316347364771	0.456317804855234	ZNF326/AGO2/DHX9/HNRNPU/BRD4/NCOA3	6
GO:0001099	basal RNA polymerase II transcription machinery binding	6/897	70/18367	0.126316347364771	0.456317804855234	ZNF326/AGO2/DHX9/HNRNPU/BRD4/NCOA3	6
GO:0004177	aminopeptidase activity	4/897	40/18367	0.129668465829401	0.460899892307215	ENPEP/DPP4/CTSV/NPEPPS	4
GO:0005542	folic acid binding	2/897	13/18367	0.130242760801924	0.460899892307215	TYMS/DHFR	2
GO:0016840	carbon-nitrogen lyase activity	2/897	13/18367	0.130242760801924	0.460899892307215	GGCT/APMAP	2
GO:0019104	DNA N-glycosylase activity	2/897	13/18367	0.130242760801924	0.460899892307215	PCNA/UNG	2
GO:0051011	microtubule minus-end binding	2/897	13/18367	0.130242760801924	0.460899892307215	CAMSAP2/MACF1	2
GO:0019787	ubiquitin-like protein transferase activity	28/897	458/18367	0.131208695954659	0.462430647937762	UBE2C/UBE2S/UBE2T/BRCA1/LMO7/BARD1/RNF43/DTL/KLHL42/HERC5/G2E3/ZNRF3/RNF168/NEDD4/NHLRC3/TRIM33/TRIM24/FBXO22/UBE4B/ZNF451/TRIM28/RNF217/HUWE1/CUL1/RANBP2/UBE2G2/UFL1/TRIM44	28
GO:0008509	anion transmembrane transporter activity	20/897	314/18367	0.136751282731376	0.476442181618857	SLC29A1/SLC38A1/GJA1/SLC35B4/SLC6A4/SFXN1/GABRE/SLC16A1/SLC26A2/SLC16A12/SLC35D1/SLC38A2/SLC1A5/ANKH/SLC25A1/ANO6/SLC2A1/SLC13A3/CLDN4/SLC25A5	20
GO:0016859	cis-trans isomerase activity	4/897	41/18367	0.138481464553578	0.476442181618857	PPIC/NKTR/DEGS1/PPIG	4
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/897	41/18367	0.138481464553578	0.476442181618857	COL14A1/COL4A2/COL5A2/COL21A1	4
GO:0030331	estrogen receptor binding	4/897	41/18367	0.138481464553578	0.476442181618857	PCNA/FUS/PARP1/CNOT1	4
GO:0048487	beta-tubulin binding	4/897	41/18367	0.138481464553578	0.476442181618857	SMC3/RACGAP1/LRPPRC/CCT5	4
GO:0061733	peptide-lysine-N-acetyltransferase activity	4/897	41/18367	0.138481464553578	0.476442181618857	BRCA2/HAT1/USP22/NCOA3	4
GO:0015215	nucleotide transmembrane transporter activity	3/897	27/18367	0.142988113909477	0.486159587292223	SLC29A1/SLC25A36/SLC25A5	3
GO:0023026	MHC class II protein complex binding	3/897	27/18367	0.142988113909477	0.486159587292223	HSP90AA1/HSPA8/HSP90AB1	3
GO:0045499	chemorepellent activity	3/897	27/18367	0.142988113909477	0.486159587292223	DPP4/SEMA6D/SEMA6A	3
GO:0004536	deoxyribonuclease activity	5/897	57/18367	0.144705334348757	0.48633385208737	FEN1/RAD51C/ZGRF1/DICER1/RAD50	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	5/897	57/18367	0.144705334348757	0.48633385208737	PDIA6/PDIA4/TMX1/PDIA3/P4HB	5
GO:0015370	solute:sodium symporter activity	6/897	73/18367	0.145762467421809	0.48633385208737	SLC38A1/SLC20A1/SLC6A4/SLC5A3/SLC38A2/SLC13A3	6
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	19/897	299/18367	0.146218420398476	0.48633385208737	PCNA/FUS/PARP1/TCERG1/YWHAH/CDKN2A/BRD8/ASXL1/DHX9/SMARCA4/TRIM24/CHD4/CNOT1/CALR/HDAC2/RBPJ/THRAP3/NCOA3/HMGA1	19
GO:0015926	glucosidase activity	2/897	14/18367	0.147246117805519	0.48633385208737	AGL/GANAB	2
GO:0019992	diacylglycerol binding	2/897	14/18367	0.147246117805519	0.48633385208737	CHPT1/DGKD	2
GO:0045182	translation regulator activity	10/897	140/18367	0.147293707119844	0.48633385208737	TYMS/DHFR/IGF2BP3/AGO2/EIF3A/LARP1/EIF4G1/FMR1/PURA/EIF1AX	10
GO:0019205	nucleobase-containing compound kinase activity	4/897	42/18367	0.147526877853493	0.48633385208737	N4BP2/TK1/DTYMK/DLG1	4
GO:1901681	sulfur compound binding	17/897	265/18367	0.153287084943741	0.503408722144786	APLP2/FBN1/NRP2/APP/DHTKD1/ADGRG1/BMP7/NRP1/FSTL1/ADAMTS1/CCDC80/TGFBR3/HADHA/LRP1/PCOLCE2/LRPAP1/DBI	17
GO:0016407	acetyltransferase activity	7/897	91/18367	0.15640153399229	0.508628110746543	BRCA2/HAT1/ACAT2/ESCO2/USP22/HADHA/NCOA3	7
GO:0005539	glycosaminoglycan binding	15/897	230/18367	0.156636338603607	0.508628110746543	HMMR/APLP2/FBN1/NRP2/APP/ADGRG1/BMP7/NRP1/FSTL1/ADAMTS1/EXTL2/CCDC80/TGFBR3/PCOLCE2/LRPAP1	15
GO:0061134	peptidase regulator activity	15/897	230/18367	0.156636338603607	0.508628110746543	PTTG1/BIRC5/APLP2/ITIH5/APP/CASP8AP2/CRIM1/FBLN1/SPINT1/SPINT2/SERPINH1/USP14/PCOLCE2/SERPINF1/PSMD14	15
GO:0090079	translation regulator activity, nucleic acid binding	8/897	108/18367	0.157908416109471	0.508689852410044	TYMS/DHFR/AGO2/EIF3A/LARP1/EIF4G1/PURA/EIF1AX	8
GO:0019783	ubiquitin-like protein-specific protease activity	9/897	125/18367	0.157919883034731	0.508689852410044	USP1/USP48/USP22/USP10/USP27X/USP9X/USP14/USP47/PSMD14	9
GO:0042277	peptide binding	20/897	321/18367	0.158415524971986	0.508689852410044	KPNA2/MME/KPNB1/ENPEP/DHCR24/CTSV/PPIC/IGF1R/CLSTN1/IPO5/FZD5/NKTR/PRLR/TNPO1/NPEPPS/CALR/LRP1/PPIG/LRPAP1/HSP90AB1	20
GO:0030695	GTPase regulator activity	29/897	488/18367	0.15980497213633	0.509378348684552	DEPDC1/ECT2/HACD3/IQGAP2/ARHGAP11A/IPO7/NRP1/RACGAP1/ARHGAP21/ARHGAP11B/CHML/GPSM2/IPO5/RAB3IP/SYDE2/ARFGEF3/ADRB1/NF1/RANBP1/ARHGAP5/DOCK9/PLXNB1/NET1/IQGAP1/ARHGAP23/ARHGAP10/RANBP2/ASAP1/RASA1	29
GO:0060589	nucleoside-triphosphatase regulator activity	29/897	488/18367	0.15980497213633	0.509378348684552	DEPDC1/ECT2/HACD3/IQGAP2/ARHGAP11A/IPO7/NRP1/RACGAP1/ARHGAP21/ARHGAP11B/CHML/GPSM2/IPO5/RAB3IP/SYDE2/ARFGEF3/ADRB1/NF1/RANBP1/ARHGAP5/DOCK9/PLXNB1/NET1/IQGAP1/ARHGAP23/ARHGAP10/RANBP2/ASAP1/RASA1	29
GO:0016829	lyase activity	13/897	196/18367	0.163292057206986	0.514219812380501	HMGB1/HACD3/GGCT/GLDC/POLQ/ENOSF1/PAICS/UXS1/ECHDC2/HADHA/APMAP/XRCC5/XRCC6	13
GO:0019902	phosphatase binding	13/897	196/18367	0.163292057206986	0.514219812380501	MET/EGFR/HSP90B1/PARD3/NEK2/MASTL/DLG1/PPP1R9A/SH2D4A/CARHSP1/ANKLE2/IQGAP1/ANAPC5	13
GO:0001846	opsonin binding	2/897	15/18367	0.164664458516796	0.514219812380501	ITGAV/CALR	2
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/897	15/18367	0.164664458516796	0.514219812380501	ALDH7A1/ADH5	2
GO:1904680	peptide transmembrane transporter activity	2/897	15/18367	0.164664458516796	0.514219812380501	GJA1/SLC13A3	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	4/897	44/18367	0.166269429210715	0.514219812380501	AURKA/PBK/AURKB/TTK	4
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	3/897	29/18367	0.166661784635433	0.514219812380501	CDK1/CDK6/CDK2	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	3/897	29/18367	0.166661784635433	0.514219812380501	LBR/DHCR24/TECR	3
GO:0097472	cyclin-dependent protein kinase activity	3/897	29/18367	0.166661784635433	0.514219812380501	CDK1/CDK6/CDK2	3
GO:0038024	cargo receptor activity	6/897	77/18367	0.173641680854365	0.525433175732085	LRP2/COLEC12/SCARA3/PRSS12/VLDLR/LRP1	6
GO:0140678	molecular function inhibitor activity	9/897	128/18367	0.174101607445607	0.525433175732085	FBXO5/NCAPG2/ID4/CALM2/NEDD4/TAF3/ID1/PURA/RASA1	9
GO:0046943	carboxylic acid transmembrane transporter activity	11/897	163/18367	0.174216029255485	0.525433175732085	SLC27A2/SLC38A1/SFXN1/SLC16A1/SLC26A2/SLC16A12/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC13A3	11
GO:0033218	amide binding	24/897	400/18367	0.174693145819698	0.525433175732085	TYMS/KPNA2/MME/KPNB1/ENPEP/DHFR/DHCR24/CTSV/PPIC/IGF1R/CLSTN1/IPO5/FZD5/NKTR/PRLR/TNPO1/NPEPPS/CALR/HADHA/LRP1/PPIG/LRPAP1/DBI/HSP90AB1	24
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	7/897	94/18367	0.175521674521614	0.525433175732085	AGL/GANAB/MANBA/GUSB/HEXB/GLB1/FUCA2	7
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/897	45/18367	0.175943214454223	0.525433175732085	BAZ1B/WEE1/MELK/YES1	4
GO:0015179	L-amino acid transmembrane transporter activity	5/897	61/18367	0.176584571194138	0.525433175732085	SLC38A1/SFXN1/SLC38A2/SLC1A5/SLC7A6	5
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/897	30/18367	0.178901528870595	0.525433175732085	SLC26A2/SLC1A5/SLC13A3	3
GO:0005343	organic acid:sodium symporter activity	3/897	30/18367	0.178901528870595	0.525433175732085	SLC38A1/SLC38A2/SLC13A3	3
GO:0005342	organic acid transmembrane transporter activity	11/897	164/18367	0.179107288403958	0.525433175732085	SLC27A2/SLC38A1/SFXN1/SLC16A1/SLC26A2/SLC16A12/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC13A3	11
GO:0004519	endonuclease activity	9/897	129/18367	0.179659120005047	0.525433175732085	N4BP2/FEN1/RAD51C/RNASEH2A/ZGRF1/AGO2/DICER1/G3BP1/RAD50	9
GO:0031072	heat shock protein binding	9/897	129/18367	0.179659120005047	0.525433175732085	KPNB1/DNAJC9/TPR/TFAM/HSPA5/HDAC2/HSPA9/HSPA8/HSP90AB1	9
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/897	16/18367	0.182416823408717	0.525433175732085	ALDH7A1/ADH5	2
GO:0005283	amino acid:sodium symporter activity	2/897	16/18367	0.182416823408717	0.525433175732085	SLC38A1/SLC38A2	2
GO:0005521	lamin binding	2/897	16/18367	0.182416823408717	0.525433175732085	TMPO/LBR	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/897	16/18367	0.182416823408717	0.525433175732085	SLC1A5/SLC13A3	2
GO:0070402	NADPH binding	2/897	16/18367	0.182416823408717	0.525433175732085	DHFR/LBR	2
GO:0070403	NAD+ binding	2/897	16/18367	0.182416823408717	0.525433175732085	UXS1/HADHA	2
GO:1990380	Lys48-specific deubiquitinase activity	2/897	16/18367	0.182416823408717	0.525433175732085	USP27X/USP9X	2
GO:1990404	protein ADP-ribosylase activity	2/897	16/18367	0.182416823408717	0.525433175732085	PARP1/PARP2	2
GO:0016874	ligase activity	11/897	165/18367	0.184062628749082	0.528418209024682	SLC27A2/LIG1/GMPS/GCLM/PAICS/NAE1/SAE1/IARS2/UBA2/RIMKLB/ACSS1	11
GO:0071813	lipoprotein particle binding	3/897	31/18367	0.191376181526073	0.544010325846246	COLEC12/VLDLR/HSPD1	3
GO:0071814	protein-lipid complex binding	3/897	31/18367	0.191376181526073	0.544010325846246	COLEC12/VLDLR/HSPD1	3
GO:0140318	protein transporter activity	3/897	31/18367	0.191376181526073	0.544010325846246	LRP2/IGF1R/SEC63	3
GO:0005044	scavenger receptor activity	4/897	47/18367	0.195836187733154	0.554869198577269	COLEC12/SCARA3/PRSS12/LRP1	4
GO:0015291	secondary active transmembrane transporter activity	15/897	240/18367	0.197038777089299	0.55518235635952	SLC38A1/SLC20A1/SLC6A4/SLC16A1/SLC5A3/SLC26A2/SLC16A12/SLC35D1/SLC38A2/SLC1A5/ANKH/SLC25A1/SLC7A6/SLC13A3/SLC25A5	15
GO:0019903	protein phosphatase binding	10/897	150/18367	0.198520769603717	0.55518235635952	MET/EGFR/HSP90B1/PARD3/NEK2/MASTL/PPP1R9A/ANKLE2/IQGAP1/ANAPC5	10
GO:0140677	molecular function activator activity	10/897	150/18367	0.198520769603717	0.55518235635952	SUZ12/DBF4/RFC1/NCAPG2/CALM2/SAE1/CYB5B/ATP1B3/XRCC5/DDOST	10
GO:0005324	long-chain fatty acid transporter activity	2/897	17/18367	0.200429155179389	0.55518235635952	SLC27A2/SLC2A1	2
GO:0015278	calcium-release channel activity	2/897	17/18367	0.200429155179389	0.55518235635952	MCOLN3/PKD2	2
GO:0043024	ribosomal small subunit binding	2/897	17/18367	0.200429155179389	0.55518235635952	UNG/LARP1	2
GO:0046965	retinoid X receptor binding	2/897	17/18367	0.200429155179389	0.55518235635952	FUS/HMGA1	2
GO:0001222	transcription corepressor binding	3/897	32/18367	0.204060987824069	0.56165357601101	EZH2/SUZ12/MTF2	3
GO:0015605	organophosphate ester transmembrane transporter activity	3/897	32/18367	0.204060987824069	0.56165357601101	SLC29A1/SLC25A36/SLC25A5	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	4/897	48/18367	0.206031237551952	0.56528190809349	GMPS/GCLM/PAICS/RIMKLB	4
GO:0034212	peptide N-acetyltransferase activity	4/897	49/18367	0.216375845191664	0.581458653328573	BRCA2/HAT1/USP22/NCOA3	4
GO:0008200	ion channel inhibitor activity	3/897	33/18367	0.216931713417356	0.581458653328573	CALM2/NEDD4/RASA1	3
GO:0019956	chemokine binding	3/897	33/18367	0.216931713417356	0.581458653328573	HMGB1/ITGAV/ITGB1	3
GO:0031369	translation initiation factor binding	3/897	33/18367	0.216931713417356	0.581458653328573	LARP1/EIF4G1/FMR1	3
GO:0000295	adenine nucleotide transmembrane transporter activity	2/897	18/18367	0.218633818898633	0.581458653328573	SLC29A1/SLC25A5	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/897	18/18367	0.218633818898633	0.581458653328573	SLC29A1/SLC25A5	2
GO:0008409	5'-3' exonuclease activity	2/897	18/18367	0.218633818898633	0.581458653328573	FEN1/DCP2	2
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/897	18/18367	0.218633818898633	0.581458653328573	GCLM/AKR7A2	2
GO:0098918	structural constituent of synapse	2/897	18/18367	0.218633818898633	0.581458653328573	DLG1/ACTN1	2
GO:0140597	protein carrier activity	2/897	18/18367	0.218633818898633	0.581458653328573	EMC1/HSPA8	2
GO:0043022	ribosome binding	5/897	66/18367	0.219706652883482	0.582524978746114	RPN2/CCDC47/HSPA5/FMR1/SERBP1	5
GO:0004842	ubiquitin-protein transferase activity	25/897	433/18367	0.220392354188024	0.582561497198223	UBE2C/UBE2S/UBE2T/BRCA1/LMO7/BARD1/RNF43/DTL/KLHL42/HERC5/G2E3/ZNRF3/RNF168/NEDD4/NHLRC3/TRIM33/TRIM24/FBXO22/UBE4B/TRIM28/RNF217/HUWE1/CUL1/UBE2G2/TRIM44	25
GO:0005048	signal sequence binding	4/897	50/18367	0.226857913931342	0.597829213916333	KPNA2/KPNB1/IPO5/TNPO1	4
GO:0016248	channel inhibitor activity	3/897	34/18367	0.229964717484274	0.60418003048141	CALM2/NEDD4/RASA1	3
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/897	19/18367	0.236969152479891	0.610953773068853	GALNT11/GALNT18	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/897	19/18367	0.236969152479891	0.610953773068853	LTBP1/TGFBR3	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/897	19/18367	0.236969152479891	0.610953773068853	SLC29A1/SLC6A4	2
GO:0010314	phosphatidylinositol-5-phosphate binding	2/897	19/18367	0.236969152479891	0.610953773068853	SNX5/PLEKHA5	2
GO:0003743	translation initiation factor activity	4/897	51/18367	0.237465404805425	0.610953773068853	AGO2/EIF3A/EIF4G1/EIF1AX	4
GO:0016860	intramolecular oxidoreductase activity	4/897	51/18367	0.237465404805425	0.610953773068853	PDIA6/PDIA4/PDIA3/P4HB	4
GO:0008080	N-acetyltransferase activity	5/897	68/18367	0.237791296841142	0.610953773068853	BRCA2/HAT1/ESCO2/USP22/NCOA3	5
GO:0008238	exopeptidase activity	7/897	103/18367	0.238180363664674	0.610953773068853	GGH/MME/ENPEP/DPP4/CTSV/CPD/NPEPPS	7
GO:0061135	endopeptidase regulator activity	12/897	194/18367	0.24026748769305	0.614489415427359	PTTG1/BIRC5/APLP2/ITIH5/APP/CRIM1/SPINT1/SPINT2/SERPINH1/USP14/SERPINF1/PSMD14	12
GO:0042562	hormone binding	6/897	86/18367	0.243182152967978	0.620114490068344	LRP2/EGFR/IGF1R/ATP1A1/PRLR/CALR	6
GO:0031593	polyubiquitin modification-dependent protein binding	4/897	52/18367	0.248186370523532	0.631019305700593	AGL/RNF168/PRPF8/RAD23B	4
GO:0005096	GTPase activator activity	26/897	462/18367	0.254455447728856	0.636246070665338	DEPDC1/ECT2/HACD3/IQGAP2/ARHGAP11A/NRP1/RACGAP1/ARHGAP21/ARHGAP11B/CHML/RAB3IP/SYDE2/ARFGEF3/ADRB1/NF1/RANBP1/ARHGAP5/DOCK9/PLXNB1/NET1/IQGAP1/ARHGAP23/ARHGAP10/RANBP2/ASAP1/RASA1	26
GO:0004551	nucleotide diphosphatase activity	2/897	20/18367	0.25537904566498	0.636246070665338	NUDT15/NUDT4	2
GO:0016408	C-acyltransferase activity	2/897	20/18367	0.25537904566498	0.636246070665338	ACAT2/HADHA	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/897	20/18367	0.25537904566498	0.636246070665338	CHPT1/CDS1	2
GO:0031690	adrenergic receptor binding	2/897	20/18367	0.25537904566498	0.636246070665338	ADRB1/NEDD4	2
GO:0042288	MHC class I protein binding	2/897	20/18367	0.25537904566498	0.636246070665338	TUBB/TUBB4B	2
GO:0050145	nucleoside monophosphate kinase activity	2/897	20/18367	0.25537904566498	0.636246070665338	DTYMK/DLG1	2
GO:0023023	MHC protein complex binding	3/897	36/18367	0.256426324486972	0.637024708682535	HSP90AA1/HSPA8/HSP90AB1	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	4/897	53/18367	0.259008986720275	0.639546109121107	SLC29A1/SLC35B4/SLC35D1/SLC25A5	4
GO:0008276	protein methyltransferase activity	6/897	88/18367	0.259654244994959	0.639546109121107	EZH2/SUZ12/ICMT/DNMT3A/SETD2/ASH1L	6
GO:0051219	phosphoprotein binding	6/897	88/18367	0.259654244994959	0.639546109121107	PKD2/NEDD4/YES1/PRKCSH/THRAP3/RASA1	6
GO:0004866	endopeptidase inhibitor activity	11/897	180/18367	0.265214536937926	0.650568778047339	PTTG1/BIRC5/APLP2/ITIH5/APP/CRIM1/SPINT1/SPINT2/SERPINH1/USP14/SERPINF1	11
GO:0048029	monosaccharide binding	5/897	71/18367	0.265630158510678	0.650568778047339	COLEC12/LMAN1/PLOD2/MANBA/BSG	5
GO:0005109	frizzled binding	3/897	37/18367	0.269811116647196	0.655432328247118	RNF43/ZNRF3/RYK	3
GO:0046915	transition metal ion transmembrane transporter activity	3/897	37/18367	0.269811116647196	0.655432328247118	SLC39A10/SLC39A1/TMEM165	3
GO:0015459	potassium channel regulator activity	4/897	54/18367	0.269921580613978	0.655432328247118	DLG1/SLC5A3/AKAP9/RASA1	4
GO:0015293	symporter activity	9/897	144/18367	0.271395854487561	0.655432328247118	SLC38A1/SLC20A1/SLC6A4/SLC16A1/SLC5A3/SLC16A12/SLC38A2/SLC1A5/SLC13A3	9
GO:0016798	hydrolase activity, acting on glycosyl bonds	9/897	144/18367	0.271395854487561	0.655432328247118	PCNA/AGL/GANAB/UNG/MANBA/GUSB/HEXB/GLB1/FUCA2	9
GO:0005243	gap junction channel activity	2/897	21/18367	0.273812545813645	0.655788611106161	GJA5/GJA1	2
GO:0005385	zinc ion transmembrane transporter activity	2/897	21/18367	0.273812545813645	0.655788611106161	SLC39A10/SLC39A1	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/897	21/18367	0.273812545813645	0.655788611106161	SLC29A1/SLC25A5	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/897	38/18367	0.283270640824437	0.674713312073591	PPIC/NKTR/PPIG	3
GO:0044390	ubiquitin-like protein conjugating enzyme binding	3/897	38/18367	0.283270640824437	0.674713312073591	TCERG1/RNF217/UBA2	3
GO:0042054	histone methyltransferase activity	4/897	56/18367	0.291970922787705	0.679243337442958	EZH2/SUZ12/SETD2/ASH1L	4
GO:0051287	NAD binding	4/897	56/18367	0.291970922787705	0.679243337442958	PARP1/UXS1/HADHA/IDH2	4
GO:0000062	fatty-acyl-CoA binding	2/897	22/18367	0.292223488888378	0.679243337442958	HADHA/DBI	2
GO:0005355	glucose transmembrane transporter activity	2/897	22/18367	0.292223488888378	0.679243337442958	SLC5A3/SLC2A1	2
GO:0005416	amino acid:cation symporter activity	2/897	22/18367	0.292223488888378	0.679243337442958	SLC38A1/SLC38A2	2
GO:0015149	hexose transmembrane transporter activity	2/897	22/18367	0.292223488888378	0.679243337442958	SLC5A3/SLC2A1	2
GO:0016881	acid-amino acid ligase activity	2/897	22/18367	0.292223488888378	0.679243337442958	GCLM/PAICS	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/897	22/18367	0.292223488888378	0.679243337442958	CDC20/FBXO5	2
GO:0070034	telomerase RNA binding	2/897	22/18367	0.292223488888378	0.679243337442958	HNRNPU/DCP2	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	3/897	39/18367	0.296784954136596	0.688001484589382	POLR2J3/PRIM1/POLR2L	3
GO:0072341	modified amino acid binding	6/897	93/18367	0.301984558813581	0.698188299977	TYMS/HMGB1/MME/DHFR/ASAP1/HSPA8	6
GO:0030414	peptidase inhibitor activity	11/897	187/18367	0.306602855712713	0.699470892069888	PTTG1/BIRC5/APLP2/ITIH5/APP/CRIM1/SPINT1/SPINT2/SERPINH1/USP14/SERPINF1	11
GO:0042169	SH2 domain binding	3/897	40/18367	0.310334939675017	0.699470892069888	DAG1/ARHGAP5/KHDRBS1	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/897	23/18367	0.310570154118012	0.699470892069888	PARP1/PARP2	2
GO:0005158	insulin receptor binding	2/897	23/18367	0.310570154118012	0.699470892069888	IGF1R/PHIP	2
GO:0008483	transaminase activity	2/897	23/18367	0.310570154118012	0.699470892069888	BCAT1/GFPT1	2
GO:0070412	R-SMAD binding	2/897	23/18367	0.310570154118012	0.699470892069888	PARP1/TRIM33	2
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	2/897	23/18367	0.310570154118012	0.699470892069888	RNF168/PRPF8	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/897	23/18367	0.310570154118012	0.699470892069888	FUT8/C1GALT1	2
GO:1901567	fatty acid derivative binding	2/897	23/18367	0.310570154118012	0.699470892069888	HADHA/DBI	2
GO:0016410	N-acyltransferase activity	6/897	94/18367	0.310607028197125	0.699470892069888	BRCA2/HAT1/ESCO2/USP22/NCOA3/TGM2	6
GO:0016779	nucleotidyltransferase activity	8/897	132/18367	0.317044651033571	0.712118426026181	POLR2J3/POLQ/POLD3/POLA1/PRIM1/REV1/CDS1/POLR2L	8
GO:0015081	sodium ion transmembrane transporter activity	9/897	152/18367	0.325138741735853	0.727251412678924	SLC38A1/SLC20A1/ATP1A1/PKD2/SLC6A4/SLC5A3/SLC38A2/ATP1B3/SLC13A3	9
GO:0022853	active ion transmembrane transporter activity	15/897	267/18367	0.325629163036951	0.727251412678924	ATP2B1/SLC38A1/SLC20A1/ATP1A1/ATP13A3/SLC6A4/ATP2A2/SLC5A3/SLC26A2/SLC38A2/SLC25A1/ATP1B3/SLC13A3/CYB5A/SLC25A5	15
GO:0000030	mannosyltransferase activity	2/897	24/18367	0.328814940911348	0.727251412678924	TMTC3/DPY19L1	2
GO:0015145	monosaccharide transmembrane transporter activity	2/897	24/18367	0.328814940911348	0.727251412678924	SLC5A3/SLC2A1	2
GO:0016769	transferase activity, transferring nitrogenous groups	2/897	24/18367	0.328814940911348	0.727251412678924	BCAT1/GFPT1	2
GO:0043495	protein-membrane adaptor activity	2/897	24/18367	0.328814940911348	0.727251412678924	SYNE2/EPB41L3	2
GO:0001786	phosphatidylserine binding	4/897	60/18367	0.336658194321272	0.738854030388779	HMGB1/MME/ASAP1/HSPA8	4
GO:0001046	core promoter sequence-specific DNA binding	3/897	42/18367	0.337469660938819	0.738854030388779	EZH2/AGO2/SMARCA4	3
GO:0008307	structural constituent of muscle	3/897	42/18367	0.337469660938819	0.738854030388779	DAG1/ASPH/CSRP2	3
GO:0019894	kinesin binding	3/897	42/18367	0.337469660938819	0.738854030388779	PRC1/CLSTN1/KTN1	3
GO:0004721	phosphoprotein phosphatase activity	10/897	174/18367	0.344700812891877	0.748216830366139	CDKN3/PTPN14/DLG1/CTDSPL2/PTPRM/CTDSPL/PPM1G/PGP/PPP4R1/CAMK2G	10
GO:0005227	calcium activated cation channel activity	2/897	25/18367	0.346924066674957	0.748216830366139	TMEM63A/ANO6	2
GO:0034237	protein kinase A regulatory subunit binding	2/897	25/18367	0.346924066674957	0.748216830366139	AKAP1/AKAP9	2
GO:0035035	histone acetyltransferase binding	2/897	25/18367	0.346924066674957	0.748216830366139	PCNA/EID1	2
GO:0051019	mitogen-activated protein kinase binding	2/897	25/18367	0.346924066674957	0.748216830366139	TPR/IQGAP1	2
GO:0120227	acyl-CoA binding	2/897	25/18367	0.346924066674957	0.748216830366139	HADHA/DBI	2
GO:0018024	histone-lysine N-methyltransferase activity	3/897	43/18367	0.351020381206052	0.749592784496667	EZH2/SETD2/ASH1L	3
GO:0030547	signaling receptor inhibitor activity	3/897	43/18367	0.351020381206052	0.749592784496667	NCAPG2/LY6E/LRPAP1	3
GO:0034062	5'-3' RNA polymerase activity	3/897	43/18367	0.351020381206052	0.749592784496667	POLR2J3/PRIM1/POLR2L	3
GO:0097747	RNA polymerase activity	3/897	43/18367	0.351020381206052	0.749592784496667	POLR2J3/PRIM1/POLR2L	3
GO:0035591	signaling adaptor activity	5/897	81/18367	0.362235886793656	0.771048291109643	EPS8/DLG5/IQGAP1/KHDRBS1/MPP7	5
GO:0008375	acetylglucosaminyltransferase activity	3/897	44/18367	0.364538743547174	0.771048291109643	EXTL2/GCNT2/HEXB	3
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3/897	44/18367	0.364538743547174	0.771048291109643	DHTKD1/ALDH7A1/ADH5	3
GO:0099604	ligand-gated calcium channel activity	2/897	26/18367	0.364867284267418	0.771048291109643	MCOLN3/PKD2	2
GO:0019955	cytokine binding	8/897	139/18367	0.368814868919716	0.771048291109643	HMGB1/NRP2/ITGAV/ITGB1/NRP1/LTBP1/PRLR/TGFBR3	8
GO:0099106	ion channel regulator activity	8/897	139/18367	0.368814868919716	0.771048291109643	TSPAN13/DLG1/YWHAH/CALM2/SLC5A3/NEDD4/AKAP9/RASA1	8
GO:0048156	tau protein binding	3/897	45/18367	0.378009852768099	0.771048291109643	HSP90AA1/ROCK2/HSP90AB1	3
GO:0016836	hydro-lyase activity	4/897	64/18367	0.381582101911886	0.771048291109643	HACD3/ENOSF1/ECHDC2/HADHA	4
GO:0016405	CoA-ligase activity	2/897	27/18367	0.382617617896053	0.771048291109643	SLC27A2/ACSS1	2
GO:0022884	macromolecule transmembrane transporter activity	2/897	27/18367	0.382617617896053	0.771048291109643	HNRNPA3/SEC63	2
GO:0030507	spectrin binding	2/897	27/18367	0.382617617896053	0.771048291109643	ANK3/CAMSAP2	2
GO:0035255	ionotropic glutamate receptor binding	2/897	27/18367	0.382617617896053	0.771048291109643	FUS/CANX	2
GO:0043425	bHLH transcription factor binding	2/897	27/18367	0.382617617896053	0.771048291109643	NCAPG2/KLF5	2
GO:0051119	sugar transmembrane transporter activity	2/897	27/18367	0.382617617896053	0.771048291109643	SLC5A3/SLC2A1	2
GO:0051959	dynein light intermediate chain binding	2/897	27/18367	0.382617617896053	0.771048291109643	DYNLL2/DYNC1H1	2
GO:0070006	metalloaminopeptidase activity	2/897	27/18367	0.382617617896053	0.771048291109643	ENPEP/NPEPPS	2
GO:0015171	amino acid transmembrane transporter activity	5/897	84/18367	0.391642488984369	0.771048291109643	SLC38A1/SFXN1/SLC38A2/SLC1A5/SLC7A6	5
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/897	10/18367	0.393972771581974	0.771048291109643	RAD50	1
GO:0005384	manganese ion transmembrane transporter activity	1/897	10/18367	0.393972771581974	0.771048291109643	TMEM165	1
GO:0008239	dipeptidyl-peptidase activity	1/897	10/18367	0.393972771581974	0.771048291109643	DPP4	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/897	10/18367	0.393972771581974	0.771048291109643	DEGS1	1
GO:0016803	ether hydrolase activity	1/897	10/18367	0.393972771581974	0.771048291109643	AKR7A2	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/897	10/18367	0.393972771581974	0.771048291109643	GMPS	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/897	10/18367	0.393972771581974	0.771048291109643	ADH5	1
GO:0019531	oxalate transmembrane transporter activity	1/897	10/18367	0.393972771581974	0.771048291109643	SLC26A2	1
GO:0030957	Tat protein binding	1/897	10/18367	0.393972771581974	0.771048291109643	SMARCA4	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/897	10/18367	0.393972771581974	0.771048291109643	HDAC2	1
GO:0031419	cobalamin binding	1/897	10/18367	0.393972771581974	0.771048291109643	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/897	10/18367	0.393972771581974	0.771048291109643	SLC27A2	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/897	10/18367	0.393972771581974	0.771048291109643	HDAC2	1
GO:0045294	alpha-catenin binding	1/897	10/18367	0.393972771581974	0.771048291109643	VCL	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/897	10/18367	0.393972771581974	0.771048291109643	ASH1L	1
GO:0070008	serine-type exopeptidase activity	1/897	10/18367	0.393972771581974	0.771048291109643	CPD	1
GO:0070016	armadillo repeat domain binding	1/897	10/18367	0.393972771581974	0.771048291109643	CNOT1	1
GO:0070567	cytidylyltransferase activity	1/897	10/18367	0.393972771581974	0.771048291109643	CDS1	1
GO:0097027	ubiquitin-protein transferase activator activity	1/897	10/18367	0.393972771581974	0.771048291109643	CDC20	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/897	10/18367	0.393972771581974	0.771048291109643	ADRB1	1
GO:0015294	solute:cation symporter activity	6/897	104/18367	0.398248223871565	0.776132031005934	SLC38A1/SLC20A1/SLC6A4/SLC5A3/SLC38A2/SLC13A3	6
GO:0003785	actin monomer binding	2/897	28/18367	0.400151116331779	0.776132031005934	COBL/LIMA1	2
GO:0050681	androgen receptor binding	2/897	28/18367	0.400151116331779	0.776132031005934	SMARCA4/CALR	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/897	28/18367	0.400151116331779	0.776132031005934	SNX5/PLEKHA5	2
GO:1990782	protein tyrosine kinase binding	6/897	105/18367	0.407050618981352	0.777377206534088	PCNA/HSP90AA1/ITGB1/PTPN14/EIF3A/KHDRBS1	6
GO:0016247	channel regulator activity	8/897	145/18367	0.413716424284217	0.777377206534088	TSPAN13/DLG1/YWHAH/CALM2/SLC5A3/NEDD4/AKAP9/RASA1	8
GO:0015301	anion:anion antiporter activity	2/897	29/18367	0.417446622383361	0.777377206534088	SLC26A2/SLC25A5	2
GO:0051059	NF-kappaB binding	2/897	29/18367	0.417446622383361	0.777377206534088	CDKN2A/HDAC2	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/897	29/18367	0.417446622383361	0.777377206534088	SNX5/PLEKHA5	2
GO:0004143	diacylglycerol kinase activity	1/897	11/18367	0.423585803335037	0.777377206534088	DGKD	1
GO:0005078	MAP-kinase scaffold activity	1/897	11/18367	0.423585803335037	0.777377206534088	IQGAP1	1
GO:0005247	voltage-gated chloride channel activity	1/897	11/18367	0.423585803335037	0.777377206534088	ANO6	1
GO:0005347	ATP transmembrane transporter activity	1/897	11/18367	0.423585803335037	0.777377206534088	SLC25A5	1
GO:0005436	sodium:phosphate symporter activity	1/897	11/18367	0.423585803335037	0.777377206534088	SLC20A1	1
GO:0008199	ferric iron binding	1/897	11/18367	0.423585803335037	0.777377206534088	RRM2	1
GO:0008503	benzodiazepine receptor activity	1/897	11/18367	0.423585803335037	0.777377206534088	GABRE	1
GO:0015378	sodium:chloride symporter activity	1/897	11/18367	0.423585803335037	0.777377206534088	SLC6A4	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/897	11/18367	0.423585803335037	0.777377206534088	P4HB	1
GO:0016801	hydrolase activity, acting on ether bonds	1/897	11/18367	0.423585803335037	0.777377206534088	AKR7A2	1
GO:0017128	phospholipid scramblase activity	1/897	11/18367	0.423585803335037	0.777377206534088	ANO6	1
GO:0019855	calcium channel inhibitor activity	1/897	11/18367	0.423585803335037	0.777377206534088	CALM2	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/897	11/18367	0.423585803335037	0.777377206534088	DLG1	1
GO:0035252	UDP-xylosyltransferase activity	1/897	11/18367	0.423585803335037	0.777377206534088	GXYLT1	1
GO:0042285	xylosyltransferase activity	1/897	11/18367	0.423585803335037	0.777377206534088	GXYLT1	1
GO:0043522	leucine zipper domain binding	1/897	11/18367	0.423585803335037	0.777377206534088	PAWR	1
GO:0043560	insulin receptor substrate binding	1/897	11/18367	0.423585803335037	0.777377206534088	IGF1R	1
GO:0047676	arachidonate-CoA ligase activity	1/897	11/18367	0.423585803335037	0.777377206534088	SLC27A2	1
GO:0097157	pre-mRNA intronic binding	1/897	11/18367	0.423585803335037	0.777377206534088	PRPF8	1
GO:1901612	cardiolipin binding	1/897	11/18367	0.423585803335037	0.777377206534088	MME	1
GO:0019208	phosphatase regulator activity	6/897	107/18367	0.424618794823429	0.777377206534088	ANP32E/CALM2/PHACTR2/ANKLE2/SET/PPP4R1	6
GO:0022804	active transmembrane transporter activity	21/897	406/18367	0.425002071392339	0.777377206534088	ATP2B1/SLC38A1/SLC20A1/ATP1A1/ATP13A3/SLC6A4/SLC16A1/ATP2A2/SLC5A3/SLC26A2/SLC16A12/SLC35D1/SLC38A2/SLC1A5/ANKH/SLC25A1/SLC7A6/ATP1B3/SLC13A3/CYB5A/SLC25A5	21
GO:0019212	phosphatase inhibitor activity	3/897	49/18367	0.431152730173112	0.786967193810712	ANP32E/PHACTR2/SET	3
GO:0005217	intracellular ligand-gated ion channel activity	2/897	30/18367	0.434485557634273	0.788068725772558	MCOLN3/PKD2	2
GO:0022829	wide pore channel activity	2/897	30/18367	0.434485557634273	0.788068725772558	GJA5/GJA1	2
GO:0004521	endoribonuclease activity	4/897	69/18367	0.437177671644724	0.788068725772558	FEN1/RNASEH2A/AGO2/DICER1	4
GO:0019888	protein phosphatase regulator activity	5/897	89/18367	0.44033998186275	0.788068725772558	CALM2/PHACTR2/ANKLE2/SET/PPP4R1	5
GO:0051117	ATPase binding	5/897	89/18367	0.44033998186275	0.788068725772558	EGFR/PKD2/RDX/UBE4B/ATP1B3	5
GO:0042626	ATPase-coupled transmembrane transporter activity	6/897	109/18367	0.44211098085148	0.788068725772558	ATP2B1/ATP1A1/ATP13A3/ATP2A2/SLC26A2/ATP1B3	6
GO:0004518	nuclease activity	11/897	210/18367	0.449875616172417	0.788068725772558	N4BP2/FEN1/RAD51C/RNASEH2A/ZGRF1/AGO2/DICER1/G3BP1/DCP2/CNOT1/RAD50	11
GO:0017124	SH3 domain binding	7/897	130/18367	0.451101358680761	0.788068725772558	LRP2/PTTG1/GJA1/CIT/FUT8/KHDRBS1/CD2AP	7
GO:0000146	microfilament motor activity	2/897	31/18367	0.451251721503804	0.788068725772558	MYH10/MYO1C	2
GO:0016878	acid-thiol ligase activity	2/897	31/18367	0.451251721503804	0.788068725772558	SLC27A2/ACSS1	2
GO:0003995	acyl-CoA dehydrogenase activity	1/897	12/18367	0.451753352605492	0.788068725772558	TECR	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/897	12/18367	0.451753352605492	0.788068725772558	AKR7A2	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/897	12/18367	0.451753352605492	0.788068725772558	CDKN2A	1
GO:0008429	phosphatidylethanolamine binding	1/897	12/18367	0.451753352605492	0.788068725772558	NF1	1
GO:0015166	polyol transmembrane transporter activity	1/897	12/18367	0.451753352605492	0.788068725772558	SLC5A3	1
GO:0030955	potassium ion binding	1/897	12/18367	0.451753352605492	0.788068725772558	ATP1A1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/897	12/18367	0.451753352605492	0.788068725772558	P4HB	1
GO:0033130	acetylcholine receptor binding	1/897	12/18367	0.451753352605492	0.788068725772558	LY6E	1
GO:0034452	dynactin binding	1/897	12/18367	0.451753352605492	0.788068725772558	SNX5	1
GO:0043176	amine binding	1/897	12/18367	0.451753352605492	0.788068725772558	SLC6A4	1
GO:0043422	protein kinase B binding	1/897	12/18367	0.451753352605492	0.788068725772558	SRSF5	1
GO:0051378	serotonin binding	1/897	12/18367	0.451753352605492	0.788068725772558	SLC6A4	1
GO:0051018	protein kinase A binding	3/897	51/18367	0.457113288578181	0.793306495156346	AKAP1/RDX/AKAP9	3
GO:0001223	transcription coactivator binding	2/897	32/18367	0.467731103749119	0.793306495156346	CIT/TFAM	2
GO:0050699	WW domain binding	2/897	32/18367	0.467731103749119	0.793306495156346	KIF20B/PRRG4	2
GO:0051721	protein phosphatase 2A binding	2/897	32/18367	0.467731103749119	0.793306495156346	MASTL/ANKLE2	2
GO:1901682	sulfur compound transmembrane transporter activity	3/897	52/18367	0.46990473254071	0.793306495156346	GJA1/SLC26A2/SLC13A3	3
GO:0008168	methyltransferase activity	11/897	214/18367	0.474919662456529	0.793306495156346	TYMS/EZH2/SUZ12/ICMT/MTR/DNMT1/TARBP1/DNMT3A/SETD2/ASH1L/METTL7A	11
GO:0002161	aminoacyl-tRNA editing activity	1/897	13/18367	0.478545901922456	0.793306495156346	IARS2	1
GO:0004535	poly(A)-specific ribonuclease activity	1/897	13/18367	0.478545901922456	0.793306495156346	CNOT1	1
GO:0008035	high-density lipoprotein particle binding	1/897	13/18367	0.478545901922456	0.793306495156346	HSPD1	1
GO:0008179	adenylate cyclase binding	1/897	13/18367	0.478545901922456	0.793306495156346	CALM2	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/897	13/18367	0.478545901922456	0.793306495156346	SLC26A2	1
GO:0008417	fucosyltransferase activity	1/897	13/18367	0.478545901922456	0.793306495156346	FUT8	1
GO:0008494	translation activator activity	1/897	13/18367	0.478545901922456	0.793306495156346	LARP1	1
GO:0015271	outward rectifier potassium channel activity	1/897	13/18367	0.478545901922456	0.793306495156346	PKD2	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/897	13/18367	0.478545901922456	0.793306495156346	TARBP1	1
GO:0016594	glycine binding	1/897	13/18367	0.478545901922456	0.793306495156346	GLDC	1
GO:0022851	GABA-gated chloride ion channel activity	1/897	13/18367	0.478545901922456	0.793306495156346	GABRE	1
GO:0031432	titin binding	1/897	13/18367	0.478545901922456	0.793306495156346	CALM2	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/897	13/18367	0.478545901922456	0.793306495156346	UBE4B	1
GO:0042301	phosphate ion binding	1/897	13/18367	0.478545901922456	0.793306495156346	CHST14	1
GO:0045159	myosin II binding	1/897	13/18367	0.478545901922456	0.793306495156346	TRIOBP	1
GO:0045504	dynein heavy chain binding	1/897	13/18367	0.478545901922456	0.793306495156346	DYNC1LI2	1
GO:0061133	endopeptidase activator activity	1/897	13/18367	0.478545901922456	0.793306495156346	PSMD14	1
GO:0070700	BMP receptor binding	1/897	13/18367	0.478545901922456	0.793306495156346	BMP7	1
GO:0072542	protein phosphatase activator activity	1/897	13/18367	0.478545901922456	0.793306495156346	CALM2	1
GO:0140299	small molecule sensor activity	1/897	13/18367	0.478545901922456	0.793306495156346	TMEM63A	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/897	53/18367	0.482558477289936	0.796112812529862	SLC6A4/SLC16A1/SLC5A3	3
GO:0001530	lipopolysaccharide binding	2/897	33/18367	0.483911709576975	0.796112812529862	HMGB1/HSPD1	2
GO:0005154	epidermal growth factor receptor binding	2/897	33/18367	0.483911709576975	0.796112812529862	EFEMP1/YES1	2
GO:0140323	solute:anion antiporter activity	2/897	33/18367	0.483911709576975	0.796112812529862	SLC26A2/SLC25A5	2
GO:0002020	protease binding	7/897	135/18367	0.490717950227394	0.803298610491711	BRCA2/ADAMTSL4/ITGAV/DPP4/ITGB1/LRP1/CLTC	7
GO:0015085	calcium ion transmembrane transporter activity	7/897	135/18367	0.490717950227394	0.803298610491711	ATP2B1/ITGAV/MCOLN3/PKD2/ATP2A2/TRPM7/TMEM165	7
GO:0017022	myosin binding	4/897	74/18367	0.491255445923432	0.803298610491711	FUS/TRPM7/CALD1/TRIOBP	4
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/897	54/18367	0.495066530035581	0.803298610491711	ASPH/PLOD2/P4HB	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	7/897	136/18367	0.498544005896127	0.803298610491711	GCLM/VKORC1/HADHA/KDSR/AKR7A2/IDH2/ADH5	7
GO:0016831	carboxy-lyase activity	2/897	34/18367	0.499783396582768	0.803298610491711	PAICS/UXS1	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/897	34/18367	0.499783396582768	0.803298610491711	CIT/CDKN2A	2
GO:0043548	phosphatidylinositol 3-kinase binding	2/897	34/18367	0.499783396582768	0.803298610491711	IGF1R/ATP1A1	2
GO:0045505	dynein intermediate chain binding	2/897	34/18367	0.499783396582768	0.803298610491711	DYNLL2/DYNC1H1	2
GO:0004540	ribonuclease activity	6/897	116/18367	0.502301074748928	0.803298610491711	FEN1/RNASEH2A/AGO2/DICER1/DCP2/CNOT1	6
GO:0004065	arylsulfatase activity	1/897	14/18367	0.504030500700682	0.803298610491711	STS	1
GO:0005172	vascular endothelial growth factor receptor binding	1/897	14/18367	0.504030500700682	0.803298610491711	CD2AP	1
GO:0015373	anion:sodium symporter activity	1/897	14/18367	0.504030500700682	0.803298610491711	SLC6A4	1
GO:0015562	efflux transmembrane transporter activity	1/897	14/18367	0.504030500700682	0.803298610491711	GJA1	1
GO:0017110	nucleoside-diphosphatase activity	1/897	14/18367	0.504030500700682	0.803298610491711	NUDT15	1
GO:0032977	membrane insertase activity	1/897	14/18367	0.504030500700682	0.803298610491711	EMC1	1
GO:0035259	glucocorticoid receptor binding	1/897	14/18367	0.504030500700682	0.803298610491711	YWHAH	1
GO:0042887	amide transmembrane transporter activity	2/897	35/18367	0.515337722780831	0.812214134965285	GJA1/SLC13A3	2
GO:0045309	protein phosphorylated amino acid binding	3/897	56/18367	0.519616880316352	0.812214134965285	NEDD4/YES1/RASA1	3
GO:0003724	RNA helicase activity	4/897	77/18367	0.522647403095881	0.812214134965285	G3BP1/DHX9/DHX15/DDX17	4
GO:0004722	protein serine/threonine phosphatase activity	5/897	98/18367	0.525170167137516	0.812214134965285	CDKN3/CTDSPL2/CTDSPL/PPM1G/CAMK2G	5
GO:0004467	long-chain fatty acid-CoA ligase activity	1/897	15/18367	0.528270932285245	0.812214134965285	SLC27A2	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/897	15/18367	0.528270932285245	0.812214134965285	GABRE	1
GO:0005545	1-phosphatidylinositol binding	1/897	15/18367	0.528270932285245	0.812214134965285	EEA1	1
GO:0010851	cyclase regulator activity	1/897	15/18367	0.528270932285245	0.812214134965285	CALM2	1
GO:0015929	hexosaminidase activity	1/897	15/18367	0.528270932285245	0.812214134965285	HEXB	1
GO:0017136	NAD-dependent histone deacetylase activity	1/897	15/18367	0.528270932285245	0.812214134965285	HDAC2	1
GO:0030548	acetylcholine receptor regulator activity	1/897	15/18367	0.528270932285245	0.812214134965285	LY6E	1
GO:0034483	heparan sulfate sulfotransferase activity	1/897	15/18367	0.528270932285245	0.812214134965285	HS6ST2	1
GO:0042809	vitamin D receptor binding	1/897	15/18367	0.528270932285245	0.812214134965285	THRAP3	1
GO:0048185	activin binding	1/897	15/18367	0.528270932285245	0.812214134965285	TGFBR3	1
GO:0050998	nitric-oxide synthase binding	1/897	15/18367	0.528270932285245	0.812214134965285	SLC6A4	1
GO:0070742	C2H2 zinc finger domain binding	1/897	15/18367	0.528270932285245	0.812214134965285	SRRM2	1
GO:0071933	Arp2/3 complex binding	1/897	15/18367	0.528270932285245	0.812214134965285	IQGAP2	1
GO:0099602	neurotransmitter receptor regulator activity	1/897	15/18367	0.528270932285245	0.812214134965285	LY6E	1
GO:1901611	phosphatidylglycerol binding	1/897	15/18367	0.528270932285245	0.812214134965285	MME	1
GO:0043394	proteoglycan binding	2/897	36/18367	0.53056780503341	0.812214134965285	LRP1/CTSL	2
GO:0016741	transferase activity, transferring one-carbon groups	11/897	225/18367	0.54241028292045	0.812214134965285	TYMS/EZH2/SUZ12/ICMT/MTR/DNMT1/TARBP1/DNMT3A/SETD2/ASH1L/METTL7A	11
GO:0008186	ATP-dependent activity, acting on RNA	4/897	79/18367	0.543051568927192	0.812214134965285	G3BP1/DHX9/DHX15/DDX17	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/897	58/18367	0.543504672077577	0.812214134965285	SLC27A2/SLC16A1/SLC16A12	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/897	37/18367	0.545468187226908	0.812214134965285	ALDH7A1/ADH5	2
GO:0042056	chemoattractant activity	2/897	37/18367	0.545468187226908	0.812214134965285	HMGB2/HMGB1	2
GO:0071949	FAD binding	2/897	37/18367	0.545468187226908	0.812214134965285	DHCR24/SQLE	2
GO:0004698	calcium-dependent protein kinase C activity	1/897	16/18367	0.551327872877013	0.812214134965285	PKN2	1
GO:0005159	insulin-like growth factor receptor binding	1/897	16/18367	0.551327872877013	0.812214134965285	YWHAH	1
GO:0005402	carbohydrate:cation symporter activity	1/897	16/18367	0.551327872877013	0.812214134965285	SLC5A3	1
GO:0005523	tropomyosin binding	1/897	16/18367	0.551327872877013	0.812214134965285	CALD1	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/897	16/18367	0.551327872877013	0.812214134965285	SLC1A5	1
GO:0015923	mannosidase activity	1/897	16/18367	0.551327872877013	0.812214134965285	MANBA	1
GO:0016208	AMP binding	1/897	16/18367	0.551327872877013	0.812214134965285	ACSS1	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/897	16/18367	0.551327872877013	0.812214134965285	RAD51C	1
GO:0034979	NAD-dependent protein deacetylase activity	1/897	16/18367	0.551327872877013	0.812214134965285	HDAC2	1
GO:0140327	flippase activity	1/897	16/18367	0.551327872877013	0.812214134965285	TMEM30B	1
GO:0008194	UDP-glycosyltransferase activity	7/897	143/18367	0.552117665199297	0.812214134965285	GALNT11/GXYLT1/EXTL2/GCNT2/GALNT18/CHPF/HEXB	7
GO:0004527	exonuclease activity	4/897	80/18367	0.553083870520903	0.812214134965285	FEN1/DCP2/CNOT1/RAD50	4
GO:0016279	protein-lysine N-methyltransferase activity	3/897	59/18367	0.555186741568732	0.812214134965285	EZH2/SETD2/ASH1L	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3/897	59/18367	0.555186741568732	0.812214134965285	FEN1/DCP2/CNOT1	3
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	2/897	38/18367	0.560034717582601	0.812214134965285	DCP2/CNOT1	2
GO:0140303	intramembrane lipid transporter activity	2/897	38/18367	0.560034717582601	0.812214134965285	TMEM30B/ANO6	2
GO:0016278	lysine N-methyltransferase activity	3/897	60/18367	0.566688244055441	0.812214134965285	EZH2/SETD2/ASH1L	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/897	60/18367	0.566688244055441	0.812214134965285	LBR/DHCR24/TECR	3
GO:0030246	carbohydrate binding	13/897	271/18367	0.566803238511836	0.812214134965285	COLEC12/GALNT11/AGL/LMAN1/GANAB/PLOD2/GALNT18/MLEC/MANBA/GUSB/CANX/CALR/BSG	13
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6/897	124/18367	0.56802550249878	0.812214134965285	GCLM/HADHA/KDSR/AKR7A2/IDH2/ADH5	6
GO:0003951	NAD+ kinase activity	1/897	17/18367	0.573259042733115	0.812214134965285	DGKD	1
GO:0004659	prenyltransferase activity	1/897	17/18367	0.573259042733115	0.812214134965285	FDPS	1
GO:0004697	protein kinase C activity	1/897	17/18367	0.573259042733115	0.812214134965285	PKN2	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/897	17/18367	0.573259042733115	0.812214134965285	PTPRM	1
GO:0008308	voltage-gated anion channel activity	1/897	17/18367	0.573259042733115	0.812214134965285	ANO6	1
GO:0008484	sulfuric ester hydrolase activity	1/897	17/18367	0.573259042733115	0.812214134965285	STS	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	1/897	17/18367	0.573259042733115	0.812214134965285	CASP8AP2	1
GO:0015095	magnesium ion transmembrane transporter activity	1/897	17/18367	0.573259042733115	0.812214134965285	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/897	17/18367	0.573259042733115	0.812214134965285	SLC26A2	1
GO:0015116	sulfate transmembrane transporter activity	1/897	17/18367	0.573259042733115	0.812214134965285	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/897	17/18367	0.573259042733115	0.812214134965285	SLC7A6	1
GO:0015377	cation:chloride symporter activity	1/897	17/18367	0.573259042733115	0.812214134965285	SLC6A4	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/897	17/18367	0.573259042733115	0.812214134965285	PTPRM	1
GO:0030169	low-density lipoprotein particle binding	1/897	17/18367	0.573259042733115	0.812214134965285	COLEC12	1
GO:0030275	LRR domain binding	1/897	17/18367	0.573259042733115	0.812214134965285	PAWR	1
GO:0031420	alkali metal ion binding	1/897	17/18367	0.573259042733115	0.812214134965285	ATP1A1	1
GO:0031489	myosin V binding	1/897	17/18367	0.573259042733115	0.812214134965285	FUS	1
GO:0042800	histone methyltransferase activity (H3-K4 specific)	1/897	17/18367	0.573259042733115	0.812214134965285	ASH1L	1
GO:0043395	heparan sulfate proteoglycan binding	1/897	17/18367	0.573259042733115	0.812214134965285	LRP1	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/897	17/18367	0.573259042733115	0.812214134965285	C1GALT1	1
GO:0050780	dopamine receptor binding	1/897	17/18367	0.573259042733115	0.812214134965285	SNX5	1
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/897	39/18367	0.574264434525628	0.812214134965285	DTYMK/DLG1	2
GO:0050997	quaternary ammonium group binding	2/897	39/18367	0.574264434525628	0.812214134965285	DHTKD1/NF1	2
GO:0009055	electron transfer activity	6/897	126/18367	0.583793798210621	0.812462896632759	ASPH/GLDC/DEGS1/AKR7A2/CYB5A/ADH5	6
GO:0008237	metallopeptidase activity	9/897	190/18367	0.58544265038726	0.812462896632759	MME/ENPEP/ADAMTS6/ADAMTS19/ADAMTS1/CPD/NPEPPS/AFG3L2/PSMD14	9
GO:0004532	exoribonuclease activity	2/897	40/18367	0.588155460570397	0.812462896632759	DCP2/CNOT1	2
GO:0015144	carbohydrate transmembrane transporter activity	2/897	40/18367	0.588155460570397	0.812462896632759	SLC5A3/SLC2A1	2
GO:0017080	sodium channel regulator activity	2/897	40/18367	0.588155460570397	0.812462896632759	YWHAH/NEDD4	2
GO:0042287	MHC protein binding	2/897	40/18367	0.588155460570397	0.812462896632759	TUBB/TUBB4B	2
GO:0043014	alpha-tubulin binding	2/897	40/18367	0.588155460570397	0.812462896632759	RACGAP1/SETD2	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/897	40/18367	0.588155460570397	0.812462896632759	BIRC5/CASP8AP2	2
GO:0001540	amyloid-beta binding	4/897	84/18367	0.591999759069356	0.812462896632759	CLSTN1/FZD5/LRP1/LRPAP1	4
GO:0008135	translation factor activity, RNA binding	4/897	84/18367	0.591999759069356	0.812462896632759	AGO2/EIF3A/EIF4G1/EIF1AX	4
GO:0004550	nucleoside diphosphate kinase activity	1/897	18/18367	0.594119350017496	0.812462896632759	DTYMK	1
GO:0004708	MAP kinase kinase activity	1/897	18/18367	0.594119350017496	0.812462896632759	PBK	1
GO:0005229	intracellular calcium activated chloride channel activity	1/897	18/18367	0.594119350017496	0.812462896632759	ANO6	1
GO:0008569	minus-end-directed microtubule motor activity	1/897	18/18367	0.594119350017496	0.812462896632759	DYNC1H1	1
GO:0016755	aminoacyltransferase activity	1/897	18/18367	0.594119350017496	0.812462896632759	TGM2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/897	18/18367	0.594119350017496	0.812462896632759	MARVELD3	1
GO:0046527	glucosyltransferase activity	1/897	18/18367	0.594119350017496	0.812462896632759	ALG10B	1
GO:0048038	quinone binding	1/897	18/18367	0.594119350017496	0.812462896632759	VKORC1	1
GO:0061778	intracellular chloride channel activity	1/897	18/18367	0.594119350017496	0.812462896632759	ANO6	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/897	18/18367	0.594119350017496	0.812462896632759	PDLIM1	1
GO:0099095	ligand-gated anion channel activity	1/897	18/18367	0.594119350017496	0.812462896632759	GABRE	1
GO:1902936	phosphatidylinositol bisphosphate binding	5/897	107/18367	0.603893889183231	0.824529136884821	PARD3/SVIL/SNX5/PLEKHA5/ASAP1	5
GO:1901981	phosphatidylinositol phosphate binding	8/897	173/18367	0.613401390837775	0.833022765614721	IQGAP2/RACGAP1/PARD3/SVIL/SNX5/PLEKHA5/IQGAP1/ASAP1	8
GO:0004129	cytochrome-c oxidase activity	1/897	19/18367	0.613961027658474	0.833022765614721	CYB5A	1
GO:0004890	GABA-A receptor activity	1/897	19/18367	0.613961027658474	0.833022765614721	GABRE	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/897	19/18367	0.613961027658474	0.833022765614721	DHFR	1
GO:0051539	4 iron, 4 sulfur cluster binding	2/897	42/18367	0.614918765851697	0.833022765614721	POLA1/PPAT	2
GO:0030145	manganese ion binding	3/897	65/18367	0.621368973708828	0.84022492036805	FEN1/EXTL2/DCP2	3
GO:0005246	calcium channel regulator activity	2/897	43/18367	0.627791857785631	0.84022492036805	TSPAN13/CALM2	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/897	43/18367	0.627791857785631	0.84022492036805	PARD3/PLEKHA5	2
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/897	20/18367	0.632833763552868	0.84022492036805	EZH2	1
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/897	20/18367	0.632833763552868	0.84022492036805	HNRNPU	1
GO:0001972	retinoic acid binding	1/897	20/18367	0.632833763552868	0.84022492036805	NR2F2	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/897	20/18367	0.632833763552868	0.84022492036805	CASP8AP2	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/897	20/18367	0.632833763552868	0.84022492036805	GLDC	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/897	20/18367	0.632833763552868	0.84022492036805	CYB5A	1
GO:0019211	phosphatase activator activity	1/897	20/18367	0.632833763552868	0.84022492036805	CALM2	1
GO:0030296	protein tyrosine kinase activator activity	1/897	20/18367	0.632833763552868	0.84022492036805	CD24	1
GO:0031418	L-ascorbic acid binding	1/897	20/18367	0.632833763552868	0.84022492036805	PLOD2	1
GO:0031681	G-protein beta-subunit binding	1/897	20/18367	0.632833763552868	0.84022492036805	CCT5	1
GO:0004222	metalloendopeptidase activity	5/897	111/18367	0.636388337087784	0.843652428524631	MME/ADAMTS6/ADAMTS19/ADAMTS1/AFG3L2	5
GO:0015297	antiporter activity	4/897	89/18367	0.637712940965359	0.844117740178574	SLC26A2/SLC35D1/SLC7A6/SLC25A5	4
GO:0001784	phosphotyrosine residue binding	2/897	44/18367	0.640327720368415	0.844998681216766	YES1/RASA1	2
GO:0022839	ion gated channel activity	2/897	44/18367	0.640327720368415	0.844998681216766	TMEM63A/ANO6	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	7/897	156/18367	0.644211213149841	0.848831492098651	EZH2/ICMT/DNMT1/TARBP1/DNMT3A/SETD2/ASH1L	7
GO:0001848	complement binding	1/897	21/18367	0.650784824439829	0.85074023170043	CALR	1
GO:0004407	histone deacetylase activity	1/897	21/18367	0.650784824439829	0.85074023170043	HDAC2	1
GO:0005123	death receptor binding	1/897	21/18367	0.650784824439829	0.85074023170043	CASP8AP2	1
GO:1990381	ubiquitin-specific protease binding	1/897	21/18367	0.650784824439829	0.85074023170043	CLTC	1
GO:0051536	iron-sulfur cluster binding	3/897	68/18367	0.651834582320641	0.85074023170043	KIF4A/POLA1/PPAT	3
GO:0051540	metal cluster binding	3/897	68/18367	0.651834582320641	0.85074023170043	KIF4A/POLA1/PPAT	3
GO:0005245	voltage-gated calcium channel activity	2/897	45/18367	0.652528551419592	0.85074023170043	ITGAV/PKD2	2
GO:0004864	protein phosphatase inhibitor activity	2/897	46/18367	0.664397138020399	0.85152044653355	PHACTR2/SET	2
GO:0140296	general transcription initiation factor binding	2/897	46/18367	0.664397138020399	0.85152044653355	BDP1/HNRNPU	2
GO:0004602	glutathione peroxidase activity	1/897	22/18367	0.667859173751804	0.85152044653355	GPX8	1
GO:0005540	hyaluronic acid binding	1/897	22/18367	0.667859173751804	0.85152044653355	HMMR	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/897	22/18367	0.667859173751804	0.85152044653355	AKR7A2	1
GO:0008320	protein transmembrane transporter activity	1/897	22/18367	0.667859173751804	0.85152044653355	SEC63	1
GO:0015106	bicarbonate transmembrane transporter activity	1/897	22/18367	0.667859173751804	0.85152044653355	SLC26A2	1
GO:0015296	anion:cation symporter activity	1/897	22/18367	0.667859173751804	0.85152044653355	SLC6A4	1
GO:0015645	fatty acid ligase activity	1/897	22/18367	0.667859173751804	0.85152044653355	SLC27A2	1
GO:0016917	GABA receptor activity	1/897	22/18367	0.667859173751804	0.85152044653355	GABRE	1
GO:0017075	syntaxin-1 binding	1/897	22/18367	0.667859173751804	0.85152044653355	SLC6A4	1
GO:0030742	GTP-dependent protein binding	1/897	22/18367	0.667859173751804	0.85152044653355	EEA1	1
GO:0033558	protein deacetylase activity	1/897	22/18367	0.667859173751804	0.85152044653355	HDAC2	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/897	22/18367	0.667859173751804	0.85152044653355	BIRC5	1
GO:0050321	tau-protein kinase activity	1/897	22/18367	0.667859173751804	0.85152044653355	ROCK2	1
GO:0004860	protein kinase inhibitor activity	3/897	70/18367	0.671149162393474	0.854458625249842	NCAPG2/CIT/CDKN2A	3
GO:0035254	glutamate receptor binding	2/897	47/18367	0.675936793843237	0.858033968172894	FUS/CANX	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/897	47/18367	0.675936793843237	0.858033968172894	ADRB1/GABRE	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/897	71/18367	0.680506995441595	0.861078125455715	HINT1/HDAC2/TGM2	3
GO:0004529	exodeoxyribonuclease activity	1/897	23/18367	0.684099583735158	0.861078125455715	FEN1	1
GO:0005248	voltage-gated sodium channel activity	1/897	23/18367	0.684099583735158	0.861078125455715	PKD2	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/897	23/18367	0.684099583735158	0.861078125455715	PKN2	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/897	23/18367	0.684099583735158	0.861078125455715	FEN1	1
GO:0061659	ubiquitin-like protein ligase activity	14/897	316/18367	0.684293919768152	0.861078125455715	UBE2C/RNF43/HERC5/ZNRF3/NEDD4/NHLRC3/TRIM24/UBE4B/ZNF451/RNF217/HUWE1/RANBP2/UFL1/TRIM44	14
GO:0008235	metalloexopeptidase activity	3/897	72/18367	0.689665563212757	0.866579772906464	ENPEP/CPD/NPEPPS	3
GO:0032813	tumor necrosis factor receptor superfamily binding	2/897	49/18367	0.69804485739884	0.868921239852437	CASP8AP2/SIVA1	2
GO:0106306	protein serine phosphatase activity	3/897	73/18367	0.698625476632185	0.868921239852437	CDKN3/CTDSPL/PPM1G	3
GO:0106307	protein threonine phosphatase activity	3/897	73/18367	0.698625476632185	0.868921239852437	CDKN3/CTDSPL/PPM1G	3
GO:0001965	G-protein alpha-subunit binding	1/897	24/18367	0.699546742118802	0.868921239852437	GPSM2	1
GO:0008171	O-methyltransferase activity	1/897	24/18367	0.699546742118802	0.868921239852437	ICMT	1
GO:0010857	calcium-dependent protein kinase activity	1/897	24/18367	0.699546742118802	0.868921239852437	PKN2	1
GO:0043274	phospholipase binding	1/897	24/18367	0.699546742118802	0.868921239852437	LMNB1	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/897	24/18367	0.699546742118802	0.868921239852437	BMP7	1
GO:0004175	endopeptidase activity	19/897	430/18367	0.7066309223508	0.874900201220005	MME/USP1/DPP4/CTSV/ADAMTS6/ADAMTS19/ADAMTS1/PRSS12/USP48/GPAA1/SPPL2A/PDIA3/USP10/AFG3L2/ST14/USP9X/USP14/USP47/CTSL	19
GO:0005254	chloride channel activity	3/897	74/18367	0.707387590605794	0.874900201220005	GABRE/ANO6/CLDN4	3
GO:0019210	kinase inhibitor activity	3/897	74/18367	0.707387590605794	0.874900201220005	NCAPG2/CIT/CDKN2A	3
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/897	50/18367	0.708622025422673	0.875178484389541	PCNA/UNG	2
GO:0005112	Notch binding	1/897	25/18367	0.714239353595628	0.877118299670552	GALNT11	1
GO:0005160	transforming growth factor beta receptor binding	1/897	25/18367	0.714239353595628	0.877118299670552	TGFBR3	1
GO:0008327	methyl-CpG binding	1/897	25/18367	0.714239353595628	0.877118299670552	DNMT1	1
GO:0030247	polysaccharide binding	1/897	25/18367	0.714239353595628	0.877118299670552	AGL	1
GO:0004601	peroxidase activity	2/897	51/18367	0.71888768815102	0.881577971183782	GPX8/PRDX4	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/897	26/18367	0.728214236368757	0.883790705632866	ZDHHC12	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/897	26/18367	0.728214236368757	0.883790705632866	ZDHHC12	1
GO:0038187	pattern recognition receptor activity	1/897	26/18367	0.728214236368757	0.883790705632866	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/897	26/18367	0.728214236368757	0.883790705632866	SLC26A2	1
GO:0097602	cullin family protein binding	1/897	26/18367	0.728214236368757	0.883790705632866	DDB1	1
GO:0008146	sulfotransferase activity	2/897	52/18367	0.728847006375432	0.883790705632866	HS6ST2/CHST14	2
GO:0016830	carbon-carbon lyase activity	2/897	52/18367	0.728847006375432	0.883790705632866	PAICS/UXS1	2
GO:0017046	peptide hormone binding	2/897	52/18367	0.728847006375432	0.883790705632866	IGF1R/PRLR	2
GO:0019842	vitamin binding	6/897	148/18367	0.735179805641058	0.887964172569079	TYMS/DHTKD1/DHFR/GLDC/PLOD2/MTR	6
GO:0050661	NADP binding	2/897	53/18367	0.738505380065059	0.887964172569079	DHFR/LBR	2
GO:0004725	protein tyrosine phosphatase activity	4/897	102/18367	0.740134281866467	0.887964172569079	CDKN3/PTPN14/PTPRM/PGP	4
GO:0030971	receptor tyrosine kinase binding	3/897	78/18367	0.740482764202016	0.887964172569079	PCNA/PTPN14/EIF3A	3
GO:0001671	ATPase activator activity	1/897	27/18367	0.741506414002322	0.887964172569079	ATP1B3	1
GO:0004190	aspartic-type endopeptidase activity	1/897	27/18367	0.741506414002322	0.887964172569079	SPPL2A	1
GO:0004683	calmodulin-dependent protein kinase activity	1/897	27/18367	0.741506414002322	0.887964172569079	CAMK2G	1
GO:0004709	MAP kinase kinase kinase activity	1/897	27/18367	0.741506414002322	0.887964172569079	EGFR	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/897	27/18367	0.741506414002322	0.887964172569079	TMEM30B	1
GO:0008408	3'-5' exonuclease activity	2/897	54/18367	0.747868412758501	0.894347467395338	CNOT1/RAD50	2
GO:0004629	phospholipase C activity	1/897	28/18367	0.754149202804935	0.898141976417416	PDIA3	1
GO:0051861	glycolipid binding	1/897	28/18367	0.754149202804935	0.898141976417416	GPAA1	1
GO:0070001	aspartic-type peptidase activity	1/897	28/18367	0.754149202804935	0.898141976417416	SPPL2A	1
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	2/897	55/18367	0.756941878856443	0.900231288022683	GPX8/PRDX4	2
GO:0015103	inorganic anion transmembrane transporter activity	6/897	152/18367	0.757987449455396	0.900239888599765	SLC6A4/GABRE/SLC26A2/ANKH/ANO6/CLDN4	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	9/897	222/18367	0.761860030958249	0.901320371414911	BRCA2/HAT1/ACAT2/ESCO2/USP22/ZDHHC12/HADHA/NCOA3/TGM2	9
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/897	56/18367	0.765731693617187	0.901320371414911	PTTG1/BIRC5	2
GO:0004033	aldo-keto reductase (NADP) activity	1/897	29/18367	0.766174294962848	0.901320371414911	AKR7A2	1
GO:0004181	metallocarboxypeptidase activity	1/897	29/18367	0.766174294962848	0.901320371414911	CPD	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/897	29/18367	0.766174294962848	0.901320371414911	DHFR	1
GO:0033612	receptor serine/threonine kinase binding	1/897	29/18367	0.766174294962848	0.901320371414911	BMP7	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/897	29/18367	0.766174294962848	0.901320371414911	PLEKHA1	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/897	82/18367	0.770534079119687	0.905220930347925	PARD3/SVIL/ASAP1	3
GO:0005548	phospholipid transporter activity	2/897	57/18367	0.77424388566955	0.908348374662381	TMEM30B/ANO6	2
GO:0016417	S-acyltransferase activity	1/897	30/18367	0.777611837629351	0.911066842195469	ZDHHC12	1
GO:0046873	metal ion transmembrane transporter activity	18/897	430/18367	0.782492645311165	0.915155650041065	ATP2B1/ITGAV/SLC39A10/MCOLN3/SLC38A1/SLC20A1/ATP1A1/PKD2/SLC6A4/ATP2A2/SLC5A3/TUSC3/SLC38A2/TRPM7/SLC39A1/ATP1B3/SLC13A3/TMEM165	18
GO:0015399	primary active transmembrane transporter activity	7/897	181/18367	0.786363664920256	0.915155650041065	ATP2B1/ATP1A1/ATP13A3/ATP2A2/SLC26A2/ATP1B3/CYB5A	7
GO:0005164	tumor necrosis factor receptor binding	1/897	31/18367	0.788490508166869	0.915155650041065	SIVA1	1
GO:0008157	protein phosphatase 1 binding	1/897	31/18367	0.788490508166869	0.915155650041065	PPP1R9A	1
GO:0031210	phosphatidylcholine binding	1/897	31/18367	0.788490508166869	0.915155650041065	NF1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/897	31/18367	0.788490508166869	0.915155650041065	SLC2A1	1
GO:0090482	vitamin transmembrane transporter activity	1/897	31/18367	0.788490508166869	0.915155650041065	SLC2A1	1
GO:0016791	phosphatase activity	11/897	275/18367	0.792055636349651	0.918064487587096	CDKN3/PTPN14/ATP1A1/DLG1/CTDSPL2/PTPRM/CTDSPL/PPM1G/PGP/PPP4R1/CAMK2G	11
GO:0043177	organic acid binding	5/897	135/18367	0.794544596179804	0.91971984631227	TYMS/DHFR/NR2F2/GLDC/PLOD2	5
GO:0008175	tRNA methyltransferase activity	1/897	32/18367	0.798837585728732	0.919777140540254	TARBP1	1
GO:0008378	galactosyltransferase activity	1/897	32/18367	0.798837585728732	0.919777140540254	C1GALT1	1
GO:0031624	ubiquitin conjugating enzyme binding	1/897	32/18367	0.798837585728732	0.919777140540254	RNF217	1
GO:0048019	receptor antagonist activity	1/897	32/18367	0.798837585728732	0.919777140540254	LRPAP1	1
GO:0005253	anion channel activity	3/897	87/18367	0.804032041239796	0.92453021187653	GABRE/ANO6/CLDN4	3
GO:0043621	protein self-association	2/897	61/18367	0.805639619142675	0.925151721585032	GPSM2/SLC2A1	2
GO:0098960	postsynaptic neurotransmitter receptor activity	2/897	62/18367	0.812856452916813	0.932204424178408	ADRB1/GABRE	2
GO:0015020	glucuronosyltransferase activity	1/897	34/18367	0.81803949277592	0.936909168080215	CHPF	1
GO:0000175	3'-5'-exoribonuclease activity	1/897	35/18367	0.82694248601107	0.945856379118203	CNOT1	1
GO:0051213	dioxygenase activity	3/897	92/18367	0.83332051235861	0.951895763129006	ASPH/PLOD2/P4HB	3
GO:0042605	peptide antigen binding	1/897	36/18367	0.835410334039003	0.953027315278705	DHCR24	1
GO:0005262	calcium channel activity	4/897	119/18367	0.838898208604715	0.955748681813782	ITGAV/MCOLN3/PKD2/TRPM7	4
GO:0016409	palmitoyltransferase activity	1/897	37/18367	0.843464282561561	0.959689675827918	ZDHHC12	1
GO:0005501	retinoid binding	1/897	38/18367	0.851124541074506	0.961405604170312	NR2F2	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/897	38/18367	0.851124541074506	0.961405604170312	TAF3	1
GO:0019213	deacetylase activity	1/897	38/18367	0.851124541074506	0.961405604170312	HDAC2	1
GO:0019840	isoprenoid binding	1/897	38/18367	0.851124541074506	0.961405604170312	NR2F2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	2/897	68/18367	0.851327056086948	0.961405604170312	HS6ST2/CHST14	2
GO:0140098	catalytic activity, acting on RNA	15/897	386/18367	0.851625725493425	0.961405604170312	FEN1/POLR2J3/RNASEH2A/PRIM1/AGO2/DICER1/IARS2/G3BP1/TARBP1/DHX9/DHX15/DCP2/CNOT1/DDX17/POLR2L	15
GO:0035091	phosphatidylinositol binding	10/897	271/18367	0.857514812085322	0.964440029378873	IQGAP2/RACGAP1/PARD3/SVIL/GPAA1/SNX5/PLEKHA5/IQGAP1/EEA1/ASAP1	10
GO:0001664	G protein-coupled receptor binding	11/897	295/18367	0.858258877988133	0.964440029378873	WLS/ITGB4/RNF43/ADRB1/ZNRF3/ATP2A2/SNX5/NEDD4/RYK/HSPA8/CNIH4	11
GO:0005504	fatty acid binding	1/897	39/18367	0.858410333352108	0.964440029378873	ADH5	1
GO:0008170	N-methyltransferase activity	3/897	97/18367	0.858763209550738	0.964440029378873	EZH2/SETD2/ASH1L	3
GO:0031406	carboxylic acid binding	6/897	176/18367	0.86511699150483	0.970318799009945	TYMS/DHFR/NR2F2/GLDC/PLOD2/ADH5	6
GO:0016746	acyltransferase activity	9/897	250/18367	0.866326393990381	0.970419875438838	BRCA2/HAT1/ACAT2/ESCO2/USP22/ZDHHC12/HADHA/NCOA3/TGM2	9
GO:0004812	aminoacyl-tRNA ligase activity	1/897	41/18367	0.871930771518759	0.973916840789606	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/897	41/18367	0.871930771518759	0.973916840789606	IARS2	1
GO:0030276	clathrin binding	2/897	72/18367	0.872818206797606	0.973916840789606	LRP1/CLTC	2
GO:0033293	monocarboxylic acid binding	2/897	73/18367	0.877725044267054	0.978133179151075	NR2F2/ADH5	2
GO:0061630	ubiquitin protein ligase activity	11/897	304/18367	0.882055697631841	0.981521086777274	UBE2C/RNF43/HERC5/ZNRF3/NEDD4/NHLRC3/TRIM24/UBE4B/RNF217/HUWE1/TRIM44	11
GO:0004180	carboxypeptidase activity	1/897	43/18367	0.884161440338005	0.981521086777274	CPD	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/897	43/18367	0.884161440338005	0.981521086777274	SQLE	1
GO:0019003	GDP binding	2/897	75/18367	0.887018384120717	0.983433425872969	RAN/RHEB	2
GO:0051879	Hsp90 protein binding	1/897	44/18367	0.889831991965205	0.984036144175807	KPNB1	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/897	44/18367	0.889831991965205	0.984036144175807	GABRE	1
GO:0140223	general transcription initiation factor activity	1/897	45/18367	0.895225251977606	0.988739227343419	TAF3	1
GO:0005272	sodium channel activity	1/897	46/18367	0.900354765621099	0.993139417040067	PKD2	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	1/897	47/18367	0.905233417181488	0.997252061875921	CDKN3	1
GO:0048020	CCR chemokine receptor binding	1/897	48/18367	0.909873462202678	0.99966426196818	CNIH4	1
GO:0070851	growth factor receptor binding	4/897	141/18367	0.918218473272362	0.99966426196818	EFEMP1/APP/YES1/CD2AP	4
GO:0030159	signaling receptor complex adaptor activity	1/897	50/18367	0.918483793497589	0.99966426196818	DLG5	1
GO:0140359	ABC-type transporter activity	1/897	50/18367	0.918483793497589	0.99966426196818	ATP13A3	1
GO:0008227	G protein-coupled amine receptor activity	1/897	51/18367	0.922475715604521	0.99966426196818	ADRB1	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	5/897	170/18367	0.922558335602626	0.99966426196818	ASPH/PLOD2/DEGS1/P4HB/SQLE	5
GO:0050660	flavin adenine dinucleotide binding	2/897	85/18367	0.924400352846894	0.99966426196818	DHCR24/SQLE	2
GO:0004879	nuclear receptor activity	1/897	52/18367	0.926272356961954	0.99966426196818	NR2F2	1
GO:0016597	amino acid binding	1/897	52/18367	0.926272356961954	0.99966426196818	GLDC	1
GO:0098531	ligand-activated transcription factor activity	1/897	52/18367	0.926272356961954	0.99966426196818	NR2F2	1
GO:0016209	antioxidant activity	2/897	86/18367	0.92741749505596	0.99966426196818	GPX8/PRDX4	2
GO:0052689	carboxylic ester hydrolase activity	4/897	147/18367	0.932682205062425	0.99966426196818	PGAP1/IARS2/PON2/APMAP	4
GO:0048306	calcium-dependent protein binding	2/897	88/18367	0.933113832709859	0.99966426196818	CALM2/VLDLR	2
GO:0030170	pyridoxal phosphate binding	1/897	55/18367	0.93658371802915	0.99966426196818	GLDC	1
GO:0070279	vitamin B6 binding	1/897	56/18367	0.939690118473004	0.99966426196818	GLDC	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/897	58/18367	0.945454339059599	0.99966426196818	FDPS	1
GO:0005319	lipid transporter activity	4/897	154/18367	0.94660423930307	0.99966426196818	SLC27A2/TMEM30B/ANO6/SLC2A1	4
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/897	125/18367	0.947266980853645	0.99966426196818	HINT1/HDAC2/TGM2	3
GO:0042578	phosphoric ester hydrolase activity	12/897	366/18367	0.947983703404544	0.99966426196818	CDKN3/PTPN14/ATP1A1/DLG1/CTDSPL2/PTPRM/CTDSPL/PPM1G/PGP/PDIA3/PPP4R1/CAMK2G	12
GO:0005543	phospholipid binding	16/897	466/18367	0.94919477002754	0.99966426196818	HMGB1/MME/IQGAP2/RACGAP1/SPTBN1/PARD3/SVIL/NF1/GPAA1/SNX5/PLEKHA5/IQGAP1/EEA1/ASAP1/HSPA8/MYOF	16
GO:0022824	transmitter-gated ion channel activity	1/897	60/18367	0.950668189549613	0.99966426196818	GABRE	1
GO:0022835	transmitter-gated channel activity	1/897	60/18367	0.950668189549613	0.99966426196818	GABRE	1
GO:0005507	copper ion binding	1/897	61/18367	0.953085332389729	0.99966426196818	F5	1
GO:0008236	serine-type peptidase activity	5/897	191/18367	0.959518170907419	0.99966426196818	DPP4/CTSV/PRSS12/CPD/ST14	5
GO:0005525	GTP binding	12/897	377/18367	0.959704149166818	0.99966426196818	TUBB/TUBA1B/TUBA1C/TUBB4B/RANBP17/TUBG1/ARHGAP5/RAN/RHOBTB3/TGM2/RHEB/HSP90AB1	12
GO:0008173	RNA methyltransferase activity	1/897	65/18367	0.961627262968712	0.99966426196818	TARBP1	1
GO:0005085	guanyl-nucleotide exchange factor activity	6/897	223/18367	0.964167353510136	0.99966426196818	ECT2/RAB3IP/ARFGEF3/ADRB1/DOCK9/NET1	6
GO:0017171	serine hydrolase activity	5/897	195/18367	0.964383565194758	0.99966426196818	DPP4/CTSV/PRSS12/CPD/ST14	5
GO:0003924	GTPase activity	10/897	337/18367	0.969801631334732	0.99966426196818	TUBB/TUBA1B/TUBA1C/TUBB4B/TUBG1/ARHGAP5/RAN/RHOBTB3/RASA1/RHEB	10
GO:0004857	enzyme inhibitor activity	1/897	70/18367	0.970153876683979	0.99966426196818	FBXO5	1
GO:0000049	tRNA binding	1/897	72/18367	0.973008599100686	0.99966426196818	IARS2	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	1/897	72/18367	0.973008599100686	0.99966426196818	CYB5A	1
GO:0042379	chemokine receptor binding	1/897	72/18367	0.973008599100686	0.99966426196818	CNIH4	1
GO:0004252	serine-type endopeptidase activity	4/897	174/18367	0.973125851145899	0.99966426196818	DPP4/CTSV/PRSS12/ST14	4
GO:0015276	ligand-gated ion channel activity	3/897	143/18367	0.97313386929409	0.99966426196818	MCOLN3/PKD2/GABRE	3
GO:0022834	ligand-gated channel activity	3/897	143/18367	0.97313386929409	0.99966426196818	MCOLN3/PKD2/GABRE	3
GO:0005230	extracellular ligand-gated ion channel activity	1/897	73/18367	0.974331981806709	0.99966426196818	GABRE	1
GO:0030594	neurotransmitter receptor activity	2/897	111/18367	0.974461705458465	0.99966426196818	ADRB1/GABRE	2
GO:0019905	syntaxin binding	1/897	74/18367	0.97559054813006	0.99966426196818	SLC6A4	1
GO:0019001	guanyl nucleotide binding	12/897	398/18367	0.975773618051597	0.99966426196818	TUBB/TUBA1B/TUBA1C/TUBB4B/RANBP17/TUBG1/ARHGAP5/RAN/RHOBTB3/TGM2/RHEB/HSP90AB1	12
GO:0032561	guanyl ribonucleotide binding	12/897	398/18367	0.975773618051597	0.99966426196818	TUBB/TUBA1B/TUBA1C/TUBB4B/RANBP17/TUBG1/ARHGAP5/RAN/RHOBTB3/TGM2/RHEB/HSP90AB1	12
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	14/897	450/18367	0.976005497764996	0.99966426196818	MYBL2/MEIS2/NFIB/SOX4/TFDP1/PBX1/KLF5/NFAT5/TFCP2L1/ZFAT/ATMIN/ETV5/RBPJ/TFDP2	14
GO:0099094	ligand-gated cation channel activity	2/897	113/18367	0.976553162484673	0.99966426196818	MCOLN3/PKD2	2
GO:0046906	tetrapyrrole binding	3/897	149/18367	0.978664828558473	0.99966426196818	MTR/CYB5B/CYB5A	3
GO:0001216	DNA-binding transcription activator activity	14/897	456/18367	0.979192156725151	0.99966426196818	MYBL2/MEIS2/NFIB/SOX4/TFDP1/PBX1/KLF5/NFAT5/TFCP2L1/ZFAT/ATMIN/ETV5/RBPJ/TFDP2	14
GO:0005506	iron ion binding	3/897	151/18367	0.980254098746479	0.99966426196818	RRM2/PLOD2/CALR	3
GO:0015079	potassium ion transmembrane transporter activity	3/897	155/18367	0.983100247372597	0.99966426196818	ATP1A1/PKD2/ATP1B3	3
GO:0140101	catalytic activity, acting on a tRNA	2/897	124/18367	0.985404767385672	0.99966426196818	IARS2/TARBP1	2
GO:0022836	gated channel activity	9/897	340/18367	0.986711929177933	0.99966426196818	ITGAV/MCOLN3/PKD2/GABRE/TMEM63A/TMC5/TMEM109/TMEM150C/ANO6	9
GO:0008081	phosphoric diester hydrolase activity	1/897	89/18367	0.988521202654429	0.99966426196818	PDIA3	1
GO:0015078	proton transmembrane transporter activity	2/897	130/18367	0.988760403454026	0.99966426196818	CYB5A/SLC25A5	2
GO:0005249	voltage-gated potassium channel activity	1/897	90/18367	0.989084529124447	0.99966426196818	PKD2	1
GO:0005244	voltage-gated ion channel activity	4/897	201/18367	0.989870187143526	0.99966426196818	ITGAV/PKD2/TMEM109/ANO6	4
GO:0022832	voltage-gated channel activity	4/897	201/18367	0.989870187143526	0.99966426196818	ITGAV/PKD2/TMEM109/ANO6	4
GO:0005126	cytokine receptor binding	6/897	271/18367	0.992306958534524	0.99966426196818	CASP8AP2/PRLR/TGFBR3/SIVA1/CD2AP/CNIH4	6
GO:0004896	cytokine receptor activity	1/897	97/18367	0.992325841989353	0.99966426196818	PRLR	1
GO:0020037	heme binding	2/897	139/18367	0.992428510386105	0.99966426196818	CYB5B/CYB5A	2
GO:0005496	steroid binding	1/897	100/18367	0.993401642049895	0.99966426196818	ATP1A1	1
GO:0022843	voltage-gated cation channel activity	2/897	143/18367	0.993654925062507	0.99966426196818	ITGAV/PKD2	2
GO:0004497	monooxygenase activity	1/897	102/18367	0.994033772313364	0.99966426196818	SQLE	1
GO:0015267	channel activity	13/897	480/18367	0.994268708883193	0.99966426196818	ITGAV/MCOLN3/GJA5/GJA1/PKD2/GABRE/TMEM63A/TMC5/TRPM7/TMEM109/TMEM150C/ANO6/CLDN4	13
GO:0022803	passive transmembrane transporter activity	13/897	481/18367	0.994422171245757	0.99966426196818	ITGAV/MCOLN3/GJA5/GJA1/PKD2/GABRE/TMEM63A/TMC5/TRPM7/TMEM109/TMEM150C/ANO6/CLDN4	13
GO:0004620	phospholipase activity	1/897	104/18367	0.994605404784849	0.99966426196818	PDIA3	1
GO:0008528	G protein-coupled peptide receptor activity	2/897	147/18367	0.994686150678174	0.99966426196818	LGR5/LGR4	2
GO:0001653	peptide receptor activity	2/897	153/18367	0.995932153870701	0.99966426196818	LGR5/LGR4	2
GO:0000149	SNARE binding	1/897	110/18367	0.996012446710813	0.99966426196818	SLC6A4	1
GO:0008083	growth factor activity	2/897	162/18367	0.997282062983409	0.99966426196818	EFEMP1/BMP7	2
GO:0005267	potassium channel activity	1/897	121/18367	0.997709331575717	0.99966426196818	PKD2	1
GO:0005179	hormone activity	1/897	122/18367	0.997821944179936	0.99966426196818	FBN1	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	6/897	310/18367	0.998010201941298	0.99966426196818	PEG3/NFE2L3/ZFHX3/HIC2/IRX2/CTCF	6
GO:0005216	ion channel activity	10/897	432/18367	0.998021326373879	0.99966426196818	ITGAV/MCOLN3/PKD2/GABRE/TMEM63A/TMC5/TRPM7/TMEM150C/ANO6/CLDN4	10
GO:0003823	antigen binding	2/897	171/18367	0.998188889089622	0.99966426196818	DHCR24/TSPAN4	2
GO:0001217	DNA-binding transcription repressor activity	6/897	313/18367	0.998212450170646	0.99966426196818	PEG3/NFE2L3/ZFHX3/HIC2/IRX2/CTCF	6
GO:0016298	lipase activity	1/897	129/18367	0.998469680989276	0.99966426196818	PDIA3	1
GO:0003735	structural constituent of ribosome	2/897	182/18367	0.998900920352143	0.99966426196818	RPS21/RPS17	2
GO:0005261	cation channel activity	6/897	335/18367	0.999195464887943	0.99966426196818	ITGAV/MCOLN3/PKD2/TMEM63A/TRPM7/ANO6	6
GO:0140375	immune receptor activity	1/897	144/18367	0.999282029713108	0.99966426196818	PRLR	1
GO:0030546	signaling receptor activator activity	11/897	495/18367	0.999308679790806	0.99966426196818	HMGB2/HMGB1/EFEMP1/FBN1/APP/BMP7/DPP4/SEMA6D/SEMA6A/LRPAP1/FAM3B	11
GO:0005125	cytokine activity	3/897	235/18367	0.999370888794972	0.99966426196818	HMGB1/BMP7/FAM3B	3
GO:0048018	receptor ligand activity	10/897	487/18367	0.99966426196818	0.99966426196818	HMGB2/HMGB1/EFEMP1/FBN1/BMP7/DPP4/SEMA6D/SEMA6A/LRPAP1/FAM3B	10