ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0007059 chromosome segregation 91/896 346/18722 2.06927730868107e-42 9.87872987164342e-39 CENPF/TOP2A/MKI67/NUSAP1/PRC1/CCNB1/SMC4/UBE2C/PTTG1/BIRC5/RAD21/KIF23/SMC2/CENPE/ECT2/SMC3/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/SPC25/NCAPG/SMC1A/BRCA1/CENPW/NCAPD2/FEN1/BUB3/CENPK/CENPN/AURKB/CDCA8/NDC80/KIF4A/RACGAP1/TTK/RAD51C/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/CDCA2/FANCD2/KIF2C/CDT1/TACC3/STAG1/NCAPH/SPDL1/PDS5B/RMI2/BUB1/KIF14/CENPH/KIF18A/HJURP/KIFC1/CDK5RAP2/ESCO2/NCAPG2/NEK2/MIS18A/NDC1/KNTC1/SKA3/SMC6/TPR/SKA2/KNSTRN/TUBG1/SLF2/MCMBP/SRPK1/PDS5A/CTCF/SFPQ/HNRNPU/DYNC1H1/SMC5/RAN/CCNE1/PUM1/ANAPC5/USP9X/ATRX/SLC25A5 91 GO:0000819 sister chromatid segregation 69/896 202/18722 2.0667147642482e-40 4.93324814226045e-37 CENPF/TOP2A/NUSAP1/PRC1/CCNB1/SMC4/UBE2C/PTTG1/RAD21/KIF23/SMC2/CENPE/SMC3/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/SMC1A/NCAPD2/FEN1/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF4A/RACGAP1/TTK/RAD51C/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/KIF2C/CDT1/TACC3/STAG1/NCAPH/SPDL1/PDS5B/RMI2/BUB1/KIF14/KIF18A/KIFC1/CDK5RAP2/ESCO2/NCAPG2/NEK2/KNTC1/TPR/KNSTRN/TUBG1/SLF2/MCMBP/PDS5A/CTCF/SFPQ/HNRNPU/SMC5/RAN/ANAPC5/ATRX 69 GO:0140014 mitotic nuclear division 80/896 287/18722 2.38509750208089e-39 3.7954851583114e-36 CENPF/MKI67/NUSAP1/PRC1/CCNB1/SMC4/TPX2/UBE2C/PTTG1/UBE2S/RAD21/ANLN/KIF23/SMC2/KIF20B/CENPE/SMC3/AURKA/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/BMP7/SMC1A/NCAPD2/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF11/KIF4A/RACGAP1/TTK/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/CHEK1/CDCA2/KIF2C/CDT1/PHIP/TACC3/STAG1/NCAPH/SPDL1/LRP5/PDS5B/BUB1/KIF14/EPS8/MYBL2/PKMYT1/KIF18A/KIFC1/CDK5RAP2/NCAPG2/NEK2/KNTC1/KIF15/TPR/KNSTRN/TUBG1/MZT1/SLF2/RANBP1/PDS5A/ANKLE2/HNRNPU/SMC5/RAN/ANAPC5/ATRX 80 GO:0000280 nuclear division 95/896 439/18722 1.41279197506234e-36 1.52319788322529e-33 CENPF/TOP2A/MKI67/ASPM/NUSAP1/PRC1/CCNB1/SMC4/TPX2/UBE2C/PTTG1/UBE2S/RAD21/BRCA2/ANLN/CKS2/KIF23/SMC2/KIF20B/CENPE/SMC3/AURKA/DLGAP5/CCNB2/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/BMP7/SMC1A/RAD51AP1/NCAPD2/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF11/KIF4A/RACGAP1/TTK/RAD51C/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/CHEK1/CDCA2/FANCD2/KIF2C/CDT1/RAD51/PHIP/TACC3/STAG1/NCAPH/SPDL1/MND1/LRP5/PDS5B/BUB1/KIF14/EPS8/MYBL2/PKMYT1/KIF18A/KIFC1/CDK5RAP2/NCAPG2/NEK2/NDC1/KNTC1/KIF15/FIGNL1/TPR/KNSTRN/TUBG1/MZT1/SLF2/RANBP1/PDS5A/ANKLE2/HNRNPU/SMC5/RAD50/CALR/RAN/CCNE1/ANAPC5/ATRX 95 GO:0000070 mitotic sister chromatid segregation 60/896 168/18722 1.59530570090625e-36 1.52319788322529e-33 CENPF/NUSAP1/PRC1/CCNB1/SMC4/UBE2C/PTTG1/RAD21/KIF23/SMC2/CENPE/SMC3/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/SMC1A/NCAPD2/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF4A/RACGAP1/TTK/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/KIF2C/CDT1/TACC3/NCAPH/SPDL1/PDS5B/BUB1/KIF14/KIF18A/KIFC1/CDK5RAP2/NCAPG2/NEK2/KNTC1/TPR/KNSTRN/TUBG1/SLF2/PDS5A/HNRNPU/SMC5/RAN/ANAPC5/ATRX 60 GO:0098813 nuclear chromosome segregation 74/896 281/18722 1.27767642104767e-34 1.0166045390136e-31 CENPF/TOP2A/NUSAP1/PRC1/CCNB1/SMC4/UBE2C/PTTG1/RAD21/KIF23/SMC2/CENPE/ECT2/SMC3/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/SMC1A/NCAPD2/FEN1/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF4A/RACGAP1/TTK/RAD51C/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/FANCD2/KIF2C/CDT1/TACC3/STAG1/NCAPH/SPDL1/PDS5B/RMI2/BUB1/KIF14/KIF18A/KIFC1/CDK5RAP2/ESCO2/NCAPG2/NEK2/NDC1/KNTC1/TPR/KNSTRN/TUBG1/SLF2/MCMBP/PDS5A/CTCF/SFPQ/HNRNPU/DYNC1H1/SMC5/RAN/CCNE1/ANAPC5/ATRX 74 GO:0048285 organelle fission 95/896 488/18722 1.22688099905579e-32 8.36732841356051e-30 CENPF/TOP2A/MKI67/ASPM/NUSAP1/PRC1/CCNB1/SMC4/TPX2/UBE2C/PTTG1/UBE2S/RAD21/BRCA2/ANLN/CKS2/KIF23/SMC2/KIF20B/CENPE/SMC3/AURKA/DLGAP5/CCNB2/MAD2L1/NUF2/KPNB1/CDC20/NCAPG/BMP7/SMC1A/RAD51AP1/NCAPD2/BUB3/CENPK/AURKB/CDCA8/NDC80/KIF11/KIF4A/RACGAP1/TTK/RAD51C/ZWINT/NCAPD3/FBXO5/CDC6/PLK1/BUB1B/KIF22/CDCA5/CHEK1/CDCA2/FANCD2/KIF2C/CDT1/RAD51/PHIP/TACC3/STAG1/NCAPH/SPDL1/MND1/LRP5/PDS5B/BUB1/KIF14/EPS8/MYBL2/PKMYT1/KIF18A/KIFC1/CDK5RAP2/NCAPG2/NEK2/NDC1/KNTC1/KIF15/FIGNL1/TPR/KNSTRN/TUBG1/MZT1/SLF2/RANBP1/PDS5A/ANKLE2/HNRNPU/SMC5/RAD50/CALR/RAN/CCNE1/ANAPC5/ATRX 95 GO:0006260 DNA replication 68/896 260/18722 1.12260706055761e-31 6.69915763387751e-29 CDK1/PCNA/RRM1/NASP/DUT/BRCA2/CCNA2/NUCKS1/ORC6/EGFR/SMC3/MCM3/ATAD5/GMNN/RFC3/MCM7/RPA3/SUPT16H/MCM6/FEN1/LIG1/DBF4/MCM4/DTL/MMS22L/FBXO5/CDC6/RRM2/TOPBP1/CHEK1/SSRP1/CDT1/RFC1/RAD51/MCM10/RNASEH2A/POLQ/POLD3/RMI2/BLM/MCM2/TIMELESS/CHAF1A/RFC4/GINS2/ZGRF1/ESCO2/POLA1/NFIB/PRIM1/WDHD1/RPA1/REV1/RFC2/NAP1L1/MCM5/MCMBP/PDS5A/SET/DHX9/CDK2/RBBP4/CCNE1/PURA/RBBP7/ATRX/CACYBP/HMGA1 68 GO:0044772 mitotic cell cycle phase transition 83/896 424/18722 9.43684996824619e-29 5.00572463871192e-26 CENPF/CCNB1/UBE2C/CDK1/NASP/GTSE1/UBE2S/RAD21/ANLN/CCNA2/CKS2/PRKDC/CENPE/EGFR/AURKA/DLGAP5/CDKN3/CCNB2/APP/MAD2L1/EZH2/CLSPN/BRCA1/ITGB1/BUB3/WEE1/DBF4/AURKB/NDC80/TTK/RAD51C/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CDCA5/CHEK1/CDT1/TACC3/SPDL1/ADAMTS1/BUB1/KIF14/EPS8/MELK/BLM/PKMYT1/FOXM1/RBL1/CDK5RAP2/PKD2/MASTL/CCNF/KNTC1/SOX4/DLG1/TPR/CCND1/TFDP1/PBX1/CALM2/PPAT/CDKN2A/SKP2/NAE1/CTDSPL/RDX/BRD7/CDK6/CDK2/SMC5/KHDRBS1/BCAT1/CUL1/CCNE1/EIF4G1/ANAPC5/BRD4/USP47/DDB1 83 GO:1902850 microtubule cytoskeleton organization involved in mitosis 45/896 147/18722 1.93521588432342e-24 9.23872063175998e-22 NUSAP1/STMN1/PRC1/CCNB1/TPX2/KIF23/CENPE/SMC3/AURKA/DLGAP5/MAD2L1/NUF2/KPNB1/CDC20/SPC25/SMC1A/ITGB1/AURKB/NDC80/KIF11/KIF4A/RACGAP1/TTK/GJA1/PLK1/TACC3/STAG1/GPSM2/SPDL1/CKAP5/CENPA/MYBL2/CENPH/KIFC1/CDK5RAP2/NEK2/KIF15/TPR/TUBG1/MZT1/SETD2/HNRNPU/DYNC1H1/RAN/CLTC 45 GO:0007346 regulation of mitotic cell cycle 79/896 457/18722 9.85072361230032e-24 4.27521404773834e-21 CENPF/MKI67/NUSAP1/CCNB1/UBE2C/CDK1/GTSE1/RAD21/BRCA2/ANLN/CKS2/PRKDC/KIF20B/CENPE/EGFR/CKS1B/AURKA/DLGAP5/APP/MAD2L1/EZH2/CLSPN/BMP7/RPA3/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/RAD51C/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CDCA5/CHEK1/CDCA2/FANCD2/CDT1/PHIP/SPDL1/LRP5/ADAMTS1/BUB1/KIF14/MSH2/BLM/PKMYT1/MEIS2/RBL1/MDC1/CDK5RAP2/PKD2/NEK2/KNTC1/SOX4/DLG1/TPR/CCND1/TFDP1/PBX1/NAE1/CTDSPL/RDX/PKN2/BRD7/USP22/CDK2/HNRNPU/IQGAP1/EIF4G1/ANAPC5/BRD4/USP47/DDB1 79 GO:0033044 regulation of chromosome organization 49/896 187/18722 3.67851215103643e-23 1.46343475075399e-20 CENPF/TOP2A/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/PARP1/FEN1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDCA5/CDT1/TACC3/SPDL1/RMI2/BUB1/MCM2/CDK5RAP2/NEK2/KNTC1/TPR/SLF2/DNMT1/CTCF/HNRNPA2B1/SFPQ/HNRNPD/HNRNPU/SMC5/DCP2/TRIM28/RAD50/ANAPC5/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 49 GO:0071103 DNA conformation change 60/896 290/18722 2.56842609229095e-22 9.43205089584384e-20 TOP2A/HMGB2/NUSAP1/CCNB1/SMC4/HELLS/HMGB1/CDK1/NASP/SMC2/MCM3/HP1BP3/RFC3/MCM7/NCAPG/MCM6/CENPW/DNAJC9/NCAPD2/MCM4/NCAPD3/PLK1/CDCA5/RAD51/NCAPH/POLQ/HAT1/ASF1B/BLM/MCM2/CHAF1A/ITGB3BP/RFC4/HJURP/NCAPG2/MIS18A/MCM8/RPA1/RFC2/NAP1L1/MCM5/SRPK1/CTCF/HNRNPA2B1/G3BP1/SET/DHX9/ASCC3/SMC5/CHD4/RBBP4/RAD50/SMARCA5/PURA/ANP32B/ATRX/NAP1L4/XRCC5/HMGA1/XRCC6 60 GO:0045787 positive regulation of cell cycle 62/896 313/18722 5.56742661383721e-22 1.89849247531849e-19 NUSAP1/CCNB1/UBE2C/CDK1/RAD21/BRCA2/CKS2/KIF23/KIF20B/EGFR/CKS1B/ECT2/AURKA/DLGAP5/ATAD5/APP/MAD2L1/EZH2/RAD51AP1/FEN1/DBF4/AURKB/NDC80/RACGAP1/RAD51C/DTL/FBXO5/CDC6/CDCA5/CHEK1/CDT1/PHIP/GPSM2/LRP5/ADAMTS1/KIF14/CEP295/CENPJ/MEIS2/PKD2/SVIL/CIT/TPR/CCND1/TFDP1/SLC6A4/PBX1/SLF2/RANBP1/ROCK2/RDX/PKN2/SFPQ/USP22/HNRNPU/DYNC1H1/SMC5/CALR/EIF4G1/ANAPC5/BRD4/ATRX 62 GO:0007051 spindle organization 47/896 184/18722 9.33172676122008e-22 2.96997757053764e-19 ASPM/STMN1/PRC1/TUBB/CCNB1/TPX2/KIF23/CENPE/SMC3/AURKA/DLGAP5/CCNB2/NUF2/KPNB1/CDC20/SPC25/SMC1A/AURKB/NDC80/KIF11/KIF4A/RACGAP1/TTK/FBXO5/PLK1/TACC3/STAG1/GPSM2/CKAP5/CENPJ/MYBL2/CENPH/KIFC1/HAUS8/NEK2/KIF15/DLG1/TPR/KNSTRN/TUBG1/MZT1/HAUS1/HNRNPU/DYNC1H1/RAN/ATRX/CLTC 47 GO:0090068 positive regulation of cell cycle process 53/896 236/18722 1.44281655997157e-21 4.30500391081516e-19 NUSAP1/CCNB1/UBE2C/CDK1/RAD21/KIF23/KIF20B/EGFR/ECT2/AURKA/DLGAP5/ATAD5/APP/MAD2L1/EZH2/RAD51AP1/FEN1/DBF4/AURKB/NDC80/RACGAP1/RAD51C/DTL/FBXO5/CDC6/CDCA5/CDT1/PHIP/GPSM2/LRP5/ADAMTS1/KIF14/CEP295/CENPJ/SVIL/CIT/TPR/CCND1/TFDP1/PBX1/SLF2/RANBP1/ROCK2/RDX/PKN2/SFPQ/HNRNPU/DYNC1H1/SMC5/EIF4G1/ANAPC5/BRD4/ATRX 53 GO:0051983 regulation of chromosome segregation 33/896 91/18722 7.20292395247367e-21 2.0227505264182e-18 CENPF/MKI67/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDCA2/KIF2C/CDT1/TACC3/SPDL1/RMI2/BUB1/CDK5RAP2/KNTC1/SMC6/TPR/HNRNPU/SMC5/PUM1/ANAPC5 33 GO:0007052 mitotic spindle organization 37/896 120/18722 1.9280408132335e-20 5.1135926902093e-18 STMN1/PRC1/CCNB1/TPX2/KIF23/CENPE/SMC3/AURKA/DLGAP5/NUF2/KPNB1/CDC20/SPC25/SMC1A/AURKB/NDC80/KIF11/KIF4A/RACGAP1/TTK/PLK1/TACC3/STAG1/GPSM2/CKAP5/MYBL2/CENPH/KIFC1/NEK2/KIF15/TPR/TUBG1/MZT1/HNRNPU/DYNC1H1/RAN/CLTC 37 GO:1901990 regulation of mitotic cell cycle phase transition 58/896 299/18722 3.60096518546224e-20 9.04789883968248e-18 CENPF/CCNB1/UBE2C/CDK1/GTSE1/RAD21/ANLN/PRKDC/CENPE/EGFR/AURKA/DLGAP5/APP/MAD2L1/EZH2/CLSPN/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/RAD51C/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CDCA5/CHEK1/CDT1/SPDL1/ADAMTS1/BUB1/KIF14/BLM/RBL1/CDK5RAP2/PKD2/KNTC1/SOX4/DLG1/TPR/CCND1/TFDP1/PBX1/NAE1/CTDSPL/RDX/BRD7/CDK2/EIF4G1/ANAPC5/BRD4/USP47/DDB1 58 GO:0006302 double-strand break repair 52/896 251/18722 1.60529215258576e-19 3.83183236822221e-17 HMGB2/HMGB1/DEK/RAD21/BRCA2/PRKDC/NUCKS1/FUS/MCM3/MCM7/PARP1/RPA3/BRCA1/RIF1/MCM6/RAD51AP1/FEN1/RAD51C/MCM4/MMS22L/CDCA5/CHEK1/FANCD2/RAD51/POLQ/RMI2/MSH2/BLM/XRCC2/MCM2/TIMELESS/GINS2/FOXM1/FANCB/ESCO2/PARPBP/PARP2/POLA1/SMC6/FIGNL1/MCM8/RPA1/RNF168/SLF2/MCM5/SFPQ/SETD2/SMC5/RAD50/XRCC5/XRCC6/PSMD14 52 GO:1901987 regulation of cell cycle phase transition 65/896 390/18722 7.6800047264652e-19 1.74592107448309e-16 CENPF/CCNB1/UBE2C/CDK1/GTSE1/RAD21/ANLN/PRKDC/CENPE/EGFR/AURKA/DLGAP5/ATAD5/APP/MAD2L1/EZH2/CLSPN/BRCA1/BUB3/WEE1/DBF4/AURKB/NDC80/TTK/RAD51C/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CDCA5/CHEK1/FANCD2/CDT1/SPDL1/ADAMTS1/BUB1/KIF14/MSH2/BLM/TIMELESS/WDR76/RBL1/MDC1/CDK5RAP2/PKD2/KNTC1/SOX4/DLG1/TPR/CCND1/TFDP1/PBX1/NAE1/CTDSPL/RDX/BRD7/CDK2/EIF4G1/ANAPC5/BRD4/USP47/DDB1 65 GO:0006261 DNA-dependent DNA replication 39/896 151/18722 1.87834289932937e-18 4.07600409154472e-16 PCNA/BRCA2/NUCKS1/ORC6/MCM3/GMNN/RFC3/MCM7/MCM6/FEN1/LIG1/DBF4/MCM4/MMS22L/FBXO5/CDC6/TOPBP1/CDT1/RFC1/RAD51/MCM10/POLQ/POLD3/BLM/MCM2/TIMELESS/RFC4/ZGRF1/POLA1/PRIM1/WDHD1/RPA1/RFC2/MCM5/MCMBP/CCNE1/PURA/ATRX/HMGA1 39 GO:0033045 regulation of sister chromatid segregation 27/896 72/18722 9.36100531688277e-18 1.94301910359993e-15 CENPF/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/RMI2/BUB1/CDK5RAP2/KNTC1/TPR/HNRNPU/ANAPC5 27 GO:0000724 double-strand break repair via homologous recombination 36/896 138/18722 2.74838299724694e-17 5.46699184535704e-15 RAD21/BRCA2/NUCKS1/FUS/MCM3/MCM7/PARP1/RPA3/BRCA1/RIF1/MCM6/RAD51AP1/FEN1/RAD51C/MCM4/MMS22L/CHEK1/RAD51/POLQ/RMI2/BLM/XRCC2/MCM2/TIMELESS/GINS2/FANCB/PARPBP/SMC6/FIGNL1/MCM8/RPA1/MCM5/SFPQ/SETD2/SMC5/PSMD14 36 GO:0000725 recombinational repair 36/896 140/18722 4.55515181066525e-17 8.69851789764636e-15 RAD21/BRCA2/NUCKS1/FUS/MCM3/MCM7/PARP1/RPA3/BRCA1/RIF1/MCM6/RAD51AP1/FEN1/RAD51C/MCM4/MMS22L/CHEK1/RAD51/POLQ/RMI2/BLM/XRCC2/MCM2/TIMELESS/GINS2/FANCB/PARPBP/SMC6/FIGNL1/MCM8/RPA1/MCM5/SFPQ/SETD2/SMC5/PSMD14 36 GO:0010965 regulation of mitotic sister chromatid separation 25/896 65/18722 7.54002711665672e-17 1.38446497903535e-14 CENPF/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 25 GO:0034502 protein localization to chromosome 29/896 92/18722 1.33449648669114e-16 2.35958749165314e-14 CDK1/RAD21/BRCA2/EZH2/BUB3/AURKB/NDC80/TTK/PLK1/BUB1B/CDCA5/CDT1/SPDL1/MSH2/CENPA/ESCO2/KNTC1/MCM8/RPA1/SLF2/CTCF/SETD2/SMC5/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 29 GO:1901991 negative regulation of mitotic cell cycle phase transition 40/896 179/18722 1.66283239874703e-16 2.83512923986369e-14 CENPF/CCNB1/CDK1/GTSE1/RAD21/PRKDC/MAD2L1/EZH2/CLSPN/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/CDT1/SPDL1/BUB1/BLM/RBL1/CDK5RAP2/PKD2/KNTC1/SOX4/DLG1/TPR/CCND1/NAE1/CTDSPL/BRD7/CDK2/USP47 40 GO:0051306 mitotic sister chromatid separation 25/896 67/18722 1.76681596421571e-16 2.90854462522958e-14 CENPF/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 25 GO:0140694 non-membrane-bounded organelle assembly 59/896 367/18722 1.8704070760278e-16 2.97644112698557e-14 CENPF/ASPM/PRC1/TUBB/TPX2/ANLN/KIF23/PRKDC/CENPE/SMC3/AURKA/DLGAP5/CCNB2/KPNB1/CDC20/SMC1A/BRCA1/CENPW/ITGB1/CENPK/CENPN/CEP152/AURKB/KIF11/KIF4A/RACGAP1/FBXO5/PLK1/STAG1/GPSM2/CEP295/CENPJ/CENPA/MYBL2/CENPH/KIFC1/CDK5RAP2/HAUS8/NEK2/SASS6/KNTC1/KIF15/CCP110/CEP135/TPR/MZT1/CDS1/HAUS1/G3BP1/CDK2/HNRNPU/DYNC1H1/CNOT1/SQLE/LSM4/ASAP1/PRRC2C/CSRP2/XRCC5 59 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 24/896 62/18722 2.63955727502554e-16 4.06491820353934e-14 CENPF/CCNB1/UBE2C/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 24 GO:0007088 regulation of mitotic nuclear division 31/896 110/18722 4.18622530564923e-16 6.24532487786545e-14 CENPF/MKI67/NUSAP1/CCNB1/RAD21/KIF20B/AURKA/DLGAP5/MAD2L1/BMP7/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CHEK1/CDCA2/CDT1/PHIP/SPDL1/LRP5/BUB1/PKMYT1/CDK5RAP2/NEK2/KNTC1/TPR/ANAPC5 31 GO:0032392 DNA geometric change 28/896 90/18722 6.57045072934827e-16 9.50525205512384e-14 TOP2A/HMGB2/HMGB1/MCM3/RFC3/MCM7/MCM6/MCM4/RAD51/POLQ/BLM/MCM2/RFC4/MCM8/RPA1/RFC2/MCM5/HNRNPA2B1/G3BP1/DHX9/ASCC3/CHD4/RAD50/PURA/ATRX/XRCC5/HMGA1/XRCC6 28 GO:0010948 negative regulation of cell cycle process 51/896 294/18722 9.123043560656e-16 1.28098264584035e-13 CENPF/CCNB1/CDK1/PTTG1/GTSE1/RAD21/PRKDC/MAD2L1/EZH2/CLSPN/BMP7/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/TIMELESS/WDR76/RBL1/MDC1/CDK5RAP2/PKD2/NEK2/CCNF/KNTC1/CCP110/SOX4/DLG1/TPR/CCND1/NAE1/CTDSPL/BRD7/CDK2/USP47/ATRX 51 GO:0044784 metaphase/anaphase transition of cell cycle 24/896 65/18722 9.42864095929813e-16 1.28606662684827e-13 CENPF/CCNB1/UBE2C/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 24 GO:0006310 DNA recombination 52/896 305/18722 9.98960374168367e-16 1.32473245174438e-13 TOP2A/HMGB2/HMGB1/KPNA2/RAD21/BRCA2/PRKDC/NUCKS1/FUS/MCM3/MCM7/PARP1/RPA3/BRCA1/RIF1/MCM6/RAD51AP1/FEN1/RAD51C/MCM4/MMS22L/CHEK1/MSH6/FANCD2/RAD51/POLQ/MND1/RMI2/MSH2/BLM/XRCC2/MCM2/TIMELESS/GINS2/FANCB/PARPBP/SMC6/FIGNL1/MCM8/RPA1/RNF168/MCM5/UNG/SFPQ/SETD2/SMC5/RAD50/HSPD1/NONO/XRCC5/XRCC6/PSMD14 52 GO:0045930 negative regulation of mitotic cell cycle 45/896 235/18722 1.05543835935214e-15 1.3618007371749e-13 CENPF/CCNB1/CDK1/GTSE1/RAD21/PRKDC/EGFR/MAD2L1/EZH2/CLSPN/BMP7/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/RBL1/MDC1/CDK5RAP2/PKD2/KNTC1/SOX4/DLG1/TPR/CCND1/NAE1/CTDSPL/BRD7/CDK2/USP47 45 GO:0007093 mitotic cell cycle checkpoint signaling 33/896 129/18722 1.0988860218595e-15 1.38054786009402e-13 CENPF/CCNB1/CDK1/GTSE1/PRKDC/MAD2L1/CLSPN/BRCA1/BUB3/AURKB/NDC80/TTK/DTL/ZWINT/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/MDC1/CDK5RAP2/KNTC1/SOX4/TPR/CCND1/NAE1/CDK2 33 GO:1905818 regulation of chromosome separation 25/896 72/18722 1.28186206420545e-15 1.5691306396197e-13 CENPF/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 25 GO:0030071 regulation of mitotic metaphase/anaphase transition 23/896 60/18722 1.42908162583642e-15 1.70560892043577e-13 CENPF/CCNB1/UBE2C/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 23 GO:0051783 regulation of nuclear division 34/896 139/18722 1.75149877004548e-15 2.03942808004808e-13 CENPF/MKI67/NUSAP1/CCNB1/RAD21/KIF20B/AURKA/DLGAP5/MAD2L1/CDC20/BMP7/RAD51AP1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CHEK1/CDCA2/CDT1/PHIP/SPDL1/LRP5/BUB1/PKMYT1/CDK5RAP2/NEK2/KNTC1/TPR/CALR/ANAPC5 34 GO:0044839 cell cycle G2/M phase transition 35/896 148/18722 2.0621019301926e-15 2.34392252731892e-13 CENPF/CCNB1/CDK1/RAD21/CCNA2/AURKA/ATAD5/CCNB2/APP/CLSPN/BRCA1/WEE1/AURKB/RAD51C/DTL/FBXO5/CDC6/PLK1/TOPBP1/CHEK1/KIF14/MELK/BLM/PKMYT1/FOXM1/MASTL/CCND1/PBX1/CALM2/SKP2/NAE1/CDK2/KHDRBS1/BRD4/USP47 35 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 23/896 63/18722 5.00791698333781e-15 5.55995248336156e-13 CENPF/CCNB1/UBE2C/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 23 GO:0033047 regulation of mitotic sister chromatid segregation 20/896 46/18722 5.55486211409122e-15 6.02702539378897e-13 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/HNRNPU 20 GO:0045786 negative regulation of cell cycle 58/896 385/18722 6.71767332878258e-15 7.12670499369068e-13 CENPF/CCNB1/CDK1/PTTG1/GTSE1/RAD21/PRKDC/EGFR/MAD2L1/GMNN/EZH2/CLSPN/BMP7/BRCA1/BUB3/WEE1/IPO7/AURKB/NDC80/TTK/NR2F2/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/IPO5/TIMELESS/WDR76/RBL1/MDC1/CDK5RAP2/PKD2/NEK2/CCNF/KNTC1/CCP110/SOX4/DLG1/TPR/CCND1/CDKN2A/NAE1/CTDSPL/BRD7/CDK6/CDK2/USP47/ATRX 58 GO:0000086 G2/M transition of mitotic cell cycle 33/896 137/18722 7.38702348718069e-15 7.66644567995666e-13 CENPF/CCNB1/CDK1/RAD21/CCNA2/AURKA/APP/CLSPN/BRCA1/WEE1/AURKB/RAD51C/DTL/FBXO5/CDC6/PLK1/TOPBP1/CHEK1/KIF14/MELK/BLM/PKMYT1/FOXM1/MASTL/CCND1/PBX1/CALM2/SKP2/NAE1/CDK2/KHDRBS1/BRD4/USP47 33 GO:0008380 RNA splicing 62/896 434/18722 9.55395402315572e-15 9.70437798011605e-13 FUS/HNRNPR/PSIP1/PNN/ESRP1/TTF2/TCERG1/ZNF326/SUGP2/SRSF2/ZC3H13/SRPK1/SRSF10/RBMX/MBNL3/HNRNPA2B1/SFPQ/HNRNPA3/SF1/SRSF4/LUC7L3/DHX9/SLC38A2/HNRNPU/SNRPD1/KHDRBS1/DHX15/SRSF7/PAXBP1/SRRM2/LSM8/LSM5/SYNCRIP/KHSRP/LSM4/FMR1/PRPF8/SCAF11/AHNAK/HTATSF1/NONO/PPIG/RNPS1/HNRNPH1/THRAP3/RBM17/TRA2B/RBM25/DDX17/HSPA8/LSM2/HNRNPH3/CTNNBL1/PRPF40A/SNRPG/SF3B2/SON/HNRNPF/SRSF11/NCL/HNRNPM/SRSF5 62 GO:1901988 negative regulation of cell cycle phase transition 45/896 249/18722 9.84589021836111e-15 9.79255831301165e-13 CENPF/CCNB1/CDK1/GTSE1/RAD21/PRKDC/MAD2L1/EZH2/CLSPN/BRCA1/BUB3/WEE1/AURKB/NDC80/TTK/DTL/ZWINT/FBXO5/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/TIMELESS/WDR76/RBL1/MDC1/CDK5RAP2/PKD2/KNTC1/SOX4/DLG1/TPR/CCND1/NAE1/CTDSPL/BRD7/CDK2/USP47 45 GO:0045839 negative regulation of mitotic nuclear division 20/896 48/18722 1.51327561764333e-14 1.47436281604679e-12 CENPF/CCNB1/RAD21/MAD2L1/BMP7/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CHEK1/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 20 GO:2001251 negative regulation of chromosome organization 26/896 86/18722 1.55544181970591e-14 1.48513584945521e-12 CENPF/TOP2A/CCNB1/PTTG1/RAD21/MAD2L1/PARP1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/MCM2/CDK5RAP2/KNTC1/TPR/HNRNPU/DCP2/RAD50/ATRX 26 GO:0033046 negative regulation of sister chromatid segregation 19/896 43/18722 1.85538732295332e-14 1.6712488829772e-12 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 19 GO:0033048 negative regulation of mitotic sister chromatid segregation 19/896 43/18722 1.85538732295332e-14 1.6712488829772e-12 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 19 GO:2000816 negative regulation of mitotic sister chromatid separation 19/896 43/18722 1.85538732295332e-14 1.6712488829772e-12 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 19 GO:0051985 negative regulation of chromosome segregation 19/896 45/18722 5.16032762312018e-14 4.47916437686831e-12 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 19 GO:1905819 negative regulation of chromosome separation 19/896 45/18722 5.16032762312018e-14 4.47916437686831e-12 CENPF/CCNB1/PTTG1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 19 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 18/896 40/18722 6.14317406674659e-14 5.23705589190147e-12 CENPF/CCNB1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 18 GO:0032508 DNA duplex unwinding 25/896 84/18722 7.47067112886648e-14 6.2570147314401e-12 TOP2A/MCM3/RFC3/MCM7/MCM6/MCM4/RAD51/POLQ/BLM/MCM2/RFC4/MCM8/RPA1/RFC2/MCM5/G3BP1/DHX9/ASCC3/CHD4/RAD50/PURA/ATRX/XRCC5/HMGA1/XRCC6 25 GO:0000723 telomere maintenance 31/896 131/18722 8.1695193531737e-14 6.72435955035366e-12 PCNA/BRCA2/PRKDC/PARP1/RPA3/RIF1/HSP90AA1/FEN1/AURKB/RAD51C/RFC1/RAD51/BLM/NEK2/SMC6/RPA1/HNRNPA2B1/HNRNPD/HNRNPU/SMC5/DCP2/RAD50/CCNE1/ATRX/CCT5/XRCC5/CCT6A/XRCC6/CCT2/CCT4/HSP90AB1 31 GO:0051225 spindle assembly 29/896 117/18722 1.44711408926071e-13 1.17044122553124e-11 ASPM/PRC1/TUBB/TPX2/KIF23/SMC3/AURKA/CCNB2/KPNB1/CDC20/SMC1A/AURKB/KIF11/KIF4A/RACGAP1/FBXO5/PLK1/STAG1/GPSM2/MYBL2/KIFC1/HAUS8/NEK2/KIF15/TPR/MZT1/HAUS1/HNRNPU/DYNC1H1 29 GO:0000075 cell cycle checkpoint signaling 35/896 169/18722 1.47101955450093e-13 1.17044122553124e-11 CENPF/CCNB1/CDK1/GTSE1/PRKDC/MAD2L1/CLSPN/BRCA1/BUB3/AURKB/NDC80/TTK/DTL/ZWINT/CDC6/PLK1/BUB1B/TOPBP1/CHEK1/FANCD2/CDT1/SPDL1/BUB1/MSH2/BLM/TIMELESS/WDR76/MDC1/CDK5RAP2/KNTC1/SOX4/TPR/CCND1/NAE1/CDK2 35 GO:0051383 kinetochore organization 14/896 23/18722 1.63571751343371e-13 1.28015006707091e-11 CENPF/SMC4/SMC2/CENPE/DLGAP5/NUF2/CENPW/CENPK/CENPN/NDC80/CDT1/CENPA/CENPH/KNTC1 14 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 18/896 42/18722 1.75005536010115e-13 1.34754262727788e-11 CENPF/CCNB1/RAD21/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 18 GO:0051052 regulation of DNA metabolic process 53/896 359/18722 2.3282646219705e-13 1.76430719131542e-11 HMGB1/PCNA/DEK/KPNA2/PRKDC/NUCKS1/FUS/EGFR/RFC3/PARP1/BRCA1/RIF1/HSP90AA1/USP1/RAD51AP1/AURKB/GJA1/CHEK1/MSH6/CDT1/RAD51/POLQ/RMI2/MSH2/BLM/TIMELESS/RFC4/FOXM1/FANCB/PARPBP/NEK2/MIS18A/FIGNL1/RNF168/TFDP1/RFC2/SLF2/HNRNPA2B1/HNRNPD/DHX9/SETD2/HNRNPU/DCP2/TRIM28/RAD50/USP9X/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 53 GO:0071824 protein-DNA complex subunit organization 42/896 241/18722 2.78559342962989e-13 2.05506954887223e-11 CENPF/HMGB2/HELLS/HMGB1/NASP/CENPE/DLGAP5/HP1BP3/GMNN/SUPT16H/CENPW/DNAJC9/ANP32E/CENPK/CENPN/RAD51C/CDT1/RAD51/HAT1/ASF1B/CENPA/MCM2/CHAF1A/ITGB3BP/CENPH/HJURP/MIS18A/KNTC1/NAP1L1/SMARCC1/BDP1/CTCF/SET/SETD2/SMARCA4/RBBP4/BPTF/SMARCA5/ANP32B/ATRX/NAP1L4/HMGA1 42 GO:0051304 chromosome separation 26/896 96/18722 2.79806285456001e-13 2.05506954887223e-11 CENPF/TOP2A/CCNB1/UBE2C/PTTG1/RAD21/CENPE/DLGAP5/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/CDC6/PLK1/BUB1B/CDT1/TACC3/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR/ANAPC5 26 GO:0007062 sister chromatid cohesion 21/896 62/18722 4.30308145417993e-13 3.11256225185682e-11 RAD21/SMC3/CDC20/SMC1A/FEN1/RAD51C/PLK1/BUB1B/KIF22/CDCA5/STAG1/PDS5B/BUB1/ESCO2/SLF2/MCMBP/PDS5A/CTCF/SFPQ/SMC5/ATRX 21 GO:0051784 negative regulation of nuclear division 20/896 56/18722 4.93456979771701e-13 3.51606510661209e-11 CENPF/CCNB1/RAD21/MAD2L1/BMP7/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/CHEK1/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 20 GO:0010639 negative regulation of organelle organization 51/896 347/18722 7.93947524914468e-13 5.5739786528554e-11 CENPF/TOP2A/STMN1/CCNB1/TPX2/PTTG1/RAD21/CKAP2/MET/MAD2L1/BMP7/PARP1/BRCA1/BUB3/AURKB/NDC80/TTK/ZWINT/FBXO5/PLK1/BUB1B/SPTBN1/CHEK1/KANK1/CDT1/SPDL1/KANK4/BUB1/EPS8/MCM2/CDK5RAP2/SVIL/CCNF/KNTC1/CCP110/TPR/YAP1/PPP1R9A/RDX/HNRNPU/CAMSAP2/ADD3/DCP2/RAD50/HUWE1/TACSTD2/LIMA1/ATRX/PPFIA1/TRIOBP/SLC25A5 51 GO:0006323 DNA packaging 37/896 199/18722 9.72674860602954e-13 6.72978229640363e-11 TOP2A/HMGB2/NUSAP1/CCNB1/SMC4/HELLS/HMGB1/CDK1/NASP/SMC2/HP1BP3/NCAPG/CENPW/DNAJC9/NCAPD2/NCAPD3/PLK1/CDCA5/NCAPH/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/NCAPG2/MIS18A/NAP1L1/SRPK1/CTCF/SET/SMC5/RBBP4/SMARCA5/ANP32B/ATRX/NAP1L4 37 GO:0006325 chromatin organization 56/896 409/18722 1.16066204675238e-12 7.91571515885122e-11 MKI67/HMGB2/HELLS/HMGB1/NASP/DEK/HMGN2/NUCKS1/ATAD2/HP1BP3/EZH2/SMARCA2/SUPT16H/CENPW/BAZ1B/DNAJC9/ANP32E/SSRP1/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/RBL1/MIS18A/TPR/NAP1L1/SRPK1/MTF2/DNMT1/SMARCC1/SMARCA1/RERE/CTCF/SET/DNMT3A/SETD2/SMARCA4/HNRNPU/CHD4/RBBP4/PBRM1/BPTF/TRIM28/SMARCA5/GATAD1/CBX3/HDAC2/RBBP7/ANP32B/BRD4/ATRX/NAP1L4/HMGN1/HMGA1 56 GO:0007098 centrosome cycle 29/896 130/18722 2.55643145218818e-12 1.71893010602061e-10 CDK1/BRCA2/AURKA/BRCA1/CEP152/NDC80/KIF11/XPO1/PLK1/CHEK1/CKAP5/CEP295/CENPJ/XRCC2/CDK5RAP2/PKD2/HAUS8/NEK2/CCNF/SASS6/CCP110/CEP135/SLC16A1/RANBP1/ROCK2/HAUS1/PCM1/CDK2/PARD6B 29 GO:0000375 RNA splicing, via transesterification reactions 48/896 324/18722 2.82677493259118e-12 1.87430882335976e-10 HNRNPR/PSIP1/PNN/SRSF2/SRPK1/SRSF10/RBMX/MBNL3/HNRNPA2B1/SFPQ/HNRNPA3/SF1/SRSF4/LUC7L3/DHX9/HNRNPU/SNRPD1/KHDRBS1/SRSF7/PAXBP1/SRRM2/LSM8/LSM5/SYNCRIP/KHSRP/LSM4/FMR1/PRPF8/SCAF11/HTATSF1/RNPS1/HNRNPH1/THRAP3/RBM17/TRA2B/RBM25/DDX17/HSPA8/LSM2/HNRNPH3/PRPF40A/SNRPG/SF3B2/SON/HNRNPF/NCL/HNRNPM/SRSF5 48 GO:0007094 mitotic spindle assembly checkpoint signaling 16/896 38/18722 5.47717874849713e-12 3.48640684604337e-10 CENPF/CCNB1/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 16 GO:0071173 spindle assembly checkpoint signaling 16/896 38/18722 5.47717874849713e-12 3.48640684604337e-10 CENPF/CCNB1/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 16 GO:0071174 mitotic spindle checkpoint signaling 16/896 38/18722 5.47717874849713e-12 3.48640684604337e-10 CENPF/CCNB1/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 16 GO:0031023 microtubule organizing center organization 30/896 143/18722 5.7354817823369e-12 3.60278816169426e-10 CDK1/BRCA2/AURKA/BRCA1/CEP152/NDC80/KIF11/XPO1/PLK1/CHEK1/CKAP5/CEP295/CENPJ/XRCC2/CDK5RAP2/PKD2/HAUS8/NEK2/CCNF/SASS6/MPDZ/CCP110/CEP135/SLC16A1/RANBP1/ROCK2/HAUS1/PCM1/CDK2/PARD6B 30 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 47/896 320/18722 6.53927481549482e-12 4.00237153450927e-10 HNRNPR/PSIP1/PNN/SRSF2/SRPK1/SRSF10/RBMX/MBNL3/HNRNPA2B1/SFPQ/HNRNPA3/SF1/SRSF4/LUC7L3/DHX9/HNRNPU/SNRPD1/KHDRBS1/SRSF7/PAXBP1/SRRM2/LSM8/LSM5/SYNCRIP/LSM4/FMR1/PRPF8/SCAF11/HTATSF1/RNPS1/HNRNPH1/THRAP3/RBM17/TRA2B/RBM25/DDX17/HSPA8/LSM2/HNRNPH3/PRPF40A/SNRPG/SF3B2/SON/HNRNPF/NCL/HNRNPM/SRSF5 47 GO:0000398 mRNA splicing, via spliceosome 47/896 320/18722 6.53927481549482e-12 4.00237153450927e-10 HNRNPR/PSIP1/PNN/SRSF2/SRPK1/SRSF10/RBMX/MBNL3/HNRNPA2B1/SFPQ/HNRNPA3/SF1/SRSF4/LUC7L3/DHX9/HNRNPU/SNRPD1/KHDRBS1/SRSF7/PAXBP1/SRRM2/LSM8/LSM5/SYNCRIP/LSM4/FMR1/PRPF8/SCAF11/HTATSF1/RNPS1/HNRNPH1/THRAP3/RBM17/TRA2B/RBM25/DDX17/HSPA8/LSM2/HNRNPH3/PRPF40A/SNRPG/SF3B2/SON/HNRNPF/NCL/HNRNPM/SRSF5 47 GO:0031577 spindle checkpoint signaling 16/896 39/18722 8.87725398143386e-12 5.36455829207155e-10 CENPF/CCNB1/MAD2L1/BUB3/AURKB/NDC80/TTK/ZWINT/PLK1/BUB1B/CDT1/SPDL1/BUB1/CDK5RAP2/KNTC1/TPR 16 GO:1902749 regulation of cell cycle G2/M phase transition 25/896 102/18722 9.08716463848397e-12 5.42276549801531e-10 CENPF/CCNB1/CDK1/RAD21/AURKA/ATAD5/APP/CLSPN/BRCA1/AURKB/RAD51C/DTL/FBXO5/CDC6/PLK1/TOPBP1/CHEK1/KIF14/BLM/CCND1/PBX1/NAE1/CDK2/BRD4/USP47 25 GO:0010389 regulation of G2/M transition of mitotic cell cycle 24/896 94/18722 9.21885154940825e-12 5.4334317650463e-10 CENPF/CCNB1/CDK1/RAD21/AURKA/APP/CLSPN/BRCA1/AURKB/RAD51C/DTL/FBXO5/CDC6/PLK1/TOPBP1/CHEK1/KIF14/BLM/CCND1/PBX1/NAE1/CDK2/BRD4/USP47 24 GO:0090307 mitotic spindle assembly 20/896 65/18722 1.18176826477888e-11 6.88019719031021e-10 PRC1/TPX2/KIF23/SMC3/KPNB1/CDC20/SMC1A/AURKB/KIF11/KIF4A/RACGAP1/PLK1/STAG1/MYBL2/KIFC1/NEK2/KIF15/TPR/MZT1/HNRNPU 20 GO:0051321 meiotic cell cycle 41/896 261/18722 1.71089928327179e-11 9.8407628654693e-10 TOP2A/ASPM/SMC4/PTTG1/RAD21/BRCA2/CKS2/SMC2/SMC3/AURKA/CCNB2/NUF2/CDC20/SMC1A/RAD51AP1/NCAPD2/BUB3/TTK/RAD51C/NCAPD3/FBXO5/PLK1/BUB1B/MSH6/FANCD2/RAD51/MND1/BUB1/XRCC2/PKMYT1/KIF18A/NEK2/NDC1/FIGNL1/RPA1/TUBG1/CDK2/RAD50/CALR/CCNE1/ATRX 41 GO:0032200 telomere organization 31/896 159/18722 1.90466372099705e-11 1.08248388143333e-09 PCNA/BRCA2/PRKDC/PARP1/RPA3/RIF1/HSP90AA1/FEN1/AURKB/RAD51C/RFC1/RAD51/BLM/NEK2/SMC6/RPA1/HNRNPA2B1/HNRNPD/HNRNPU/SMC5/DCP2/RAD50/CCNE1/ATRX/CCT5/XRCC5/CCT6A/XRCC6/CCT2/CCT4/HSP90AB1 31 GO:0034508 centromere complex assembly 14/896 30/18722 2.12562273355708e-11 1.19384975647076e-09 CENPF/HELLS/NASP/CENPE/DLGAP5/CENPW/CENPK/CENPN/CENPA/ITGB3BP/CENPH/HJURP/MIS18A/KNTC1 14 GO:0044786 cell cycle DNA replication 16/896 41/18722 2.2169145333345e-11 1.23064534676034e-09 PCNA/BRCA2/MCM3/GMNN/MCM6/FEN1/LIG1/DBF4/MCM4/FBXO5/CDT1/RAD51/BLM/MCM2/POLA1/ATRX 16 GO:0051054 positive regulation of DNA metabolic process 35/896 201/18722 2.78497057415768e-11 1.51084653648054e-09 HMGB1/PCNA/PRKDC/FUS/EGFR/RFC3/PARP1/BRCA1/RIF1/HSP90AA1/RAD51AP1/AURKB/RAD51/MSH2/TIMELESS/RFC4/FOXM1/FANCB/NEK2/RNF168/RFC2/SLF2/HNRNPA2B1/HNRNPD/DHX9/TRIM28/RAD50/USP9X/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 35 GO:0065004 protein-DNA complex assembly 35/896 201/18722 2.78497057415768e-11 1.51084653648054e-09 CENPF/HMGB2/HELLS/HMGB1/NASP/CENPE/DLGAP5/HP1BP3/GMNN/CENPW/DNAJC9/CENPK/CENPN/RAD51C/CDT1/RAD51/HAT1/ASF1B/CENPA/MCM2/CHAF1A/ITGB3BP/CENPH/HJURP/MIS18A/KNTC1/NAP1L1/BDP1/SET/SMARCA4/RBBP4/SMARCA5/ANP32B/ATRX/NAP1L4 35 GO:0000910 cytokinesis 32/896 173/18722 3.86162664290515e-11 2.07139388687968e-09 NUSAP1/STMN1/PRC1/MYH10/BRCA2/ANLN/CKAP2/KIF23/KIF20B/ECT2/AURKA/AURKB/CEP55/KIF4A/RACGAP1/CDC6/PLK1/SPTBN1/ANK3/KIF14/CENPA/KIF20A/SVIL/CIT/CCP110/CALM2/ROCK2/PKN2/SETD2/RASA1/PRPF40A/SON 32 GO:0033260 nuclear DNA replication 15/896 37/18722 4.9121396742414e-11 2.60561720053649e-09 PCNA/BRCA2/MCM3/GMNN/MCM6/FEN1/LIG1/DBF4/MCM4/CDT1/RAD51/BLM/MCM2/POLA1/ATRX 15 GO:0000281 mitotic cytokinesis 20/896 71/18722 7.15320473820517e-11 3.7526812549661e-09 NUSAP1/STMN1/MYH10/ANLN/CKAP2/KIF23/KIF20B/ECT2/CEP55/KIF4A/RACGAP1/PLK1/SPTBN1/ANK3/CENPA/KIF20A/CIT/ROCK2/RASA1/SON 20 GO:0071897 DNA biosynthetic process 32/896 180/18722 1.13165303045122e-10 5.8722951819284e-09 CENPF/TYMS/PCNA/RFC3/HSP90AA1/TK1/LIG1/AURKB/DTL/GJA1/RFC1/POLQ/POLD3/RFC4/NEK2/POLA1/RPA1/TFDP1/REV1/RFC2/HNRNPA2B1/HNRNPD/HNRNPU/USP10/DCP2/RAD50/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 32 GO:0006270 DNA replication initiation 14/896 34/18722 1.70036921245029e-10 8.72856195724484e-09 ORC6/MCM3/MCM7/MCM6/MCM4/CDC6/TOPBP1/CDT1/MCM10/MCM2/POLA1/MCM5/CCNE1/PURA 14 GO:0043484 regulation of RNA splicing 28/896 148/18722 3.73155215643258e-10 1.89515212710735e-08 FUS/ESRP1/ZNF326/SRSF2/SRPK1/SRSF10/RBMX/MBNL3/SF1/SRSF4/SLC38A2/HNRNPU/KHDRBS1/SRSF7/FMR1/AHNAK/RNPS1/HNRNPH1/THRAP3/TRA2B/RBM25/DDX17/HSPA8/HNRNPH3/SON/HNRNPF/NCL/SRSF5 28 GO:1903311 regulation of mRNA metabolic process 41/896 288/18722 3.89114868810871e-10 1.95029965579007e-08 CCNB1/FUS/HNRNPR/BARD1/MYEF2/EXOSC8/SRSF2/ROCK2/SRPK1/AGO2/SRSF10/RBMX/MBNL3/CARHSP1/AHCYL1/SF1/HNRNPD/SRSF4/DHX9/HNRNPU/TAF15/KHDRBS1/TNRC6A/SRSF7/DCP2/CNOT1/LARP1/SYNCRIP/PUM1/KHSRP/FMR1/SERBP1/RNPS1/THRAP3/TRA2B/RBM25/DDX17/HSPA8/SON/NCL/HNRNPM 41 GO:0071459 protein localization to chromosome, centromeric region 12/896 25/18722 3.92184262580325e-10 1.95029965579007e-08 CDK1/BUB3/AURKB/NDC80/TTK/BUB1B/CDT1/SPDL1/CENPA/KNTC1/CTCF/SMC5 12 GO:1903046 meiotic cell cycle process 33/896 202/18722 5.77404378352503e-10 2.84178196108747e-08 TOP2A/ASPM/SMC4/PTTG1/RAD21/BRCA2/CKS2/SMC2/AURKA/CCNB2/NUF2/CDC20/RAD51AP1/NCAPD2/TTK/RAD51C/NCAPD3/FBXO5/PLK1/BUB1B/MSH6/FANCD2/RAD51/MND1/BUB1/KIF18A/NDC1/FIGNL1/TUBG1/RAD50/CALR/CCNE1/ATRX 33 GO:0007080 mitotic metaphase plate congression 16/896 50/18722 7.05517428078009e-10 3.43687775678001e-08 CCNB1/CENPE/NUF2/KPNB1/AURKB/CDCA8/NDC80/KIF22/CDCA5/KIF2C/CDT1/SPDL1/KIF14/KIF18A/KIFC1/HNRNPU 16 GO:0051310 metaphase plate congression 18/896 65/18722 8.68568904445199e-10 4.18843227254685e-08 CENPF/CCNB1/CENPE/NUF2/KPNB1/AURKB/CDCA8/NDC80/KIF22/CDCA5/KIF2C/CDT1/SPDL1/KIF14/KIF18A/KIFC1/HNRNPU/DYNC1H1 18 GO:0006275 regulation of DNA replication 23/896 107/18722 1.02309878509073e-09 4.88427360002313e-08 CDK1/PCNA/BRCA2/CCNA2/NUCKS1/EGFR/SMC3/ATAD5/GMNN/RFC3/DBF4/FBXO5/CDC6/CDT1/BLM/TIMELESS/RFC4/ESCO2/RFC2/PDS5A/DHX9/ATRX/CACYBP 23 GO:2001252 positive regulation of chromosome organization 20/896 82/18722 1.19524907093087e-09 5.64962283626135e-08 RAD21/FEN1/AURKB/CDT1/NEK2/TPR/SLF2/DNMT1/HNRNPA2B1/SFPQ/HNRNPD/SMC5/TRIM28/RAD50/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 20 GO:0022616 DNA strand elongation 11/896 22/18722 1.23318197896623e-09 5.77177526233801e-08 PCNA/NUCKS1/MCM3/RFC3/MCM7/LIG1/MCM4/POLD3/RFC4/POLA1/RAD50 11 GO:0006338 chromatin remodeling 37/896 255/18722 1.64183848122929e-09 7.60984165960061e-08 HMGB2/HELLS/NASP/HP1BP3/SMARCA2/SUPT16H/CENPW/BAZ1B/DNAJC9/ANP32E/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/MIS18A/NAP1L1/SMARCC1/SMARCA1/RERE/CTCF/SET/SETD2/SMARCA4/CHD4/RBBP4/PBRM1/BPTF/SMARCA5/GATAD1/CBX3/HDAC2/ANP32B/ATRX/NAP1L4/HMGA1 37 GO:0006282 regulation of DNA repair 25/896 130/18722 2.28260973573184e-09 1.04780566138306e-07 HMGB1/PCNA/DEK/PRKDC/FUS/EGFR/PARP1/BRCA1/RIF1/USP1/RAD51AP1/CHEK1/RAD51/POLQ/RMI2/TIMELESS/FOXM1/FANCB/PARPBP/FIGNL1/RNF168/SLF2/DHX9/SETD2/TRIM28 25 GO:0045931 positive regulation of mitotic cell cycle 24/896 121/18722 2.49066475083059e-09 1.13242224004431e-07 CCNB1/UBE2C/CDK1/BRCA2/EGFR/DLGAP5/APP/RAD51C/DTL/FBXO5/CDC6/CDCA5/CDT1/ADAMTS1/MEIS2/CCND1/TFDP1/PBX1/RDX/PKN2/USP22/EIF4G1/ANAPC5/BRD4 24 GO:0008608 attachment of spindle microtubules to kinetochore 13/896 35/18722 3.50872094446032e-09 1.58024847064656e-07 CCNB1/CENPE/ECT2/NUF2/BUB3/AURKB/NDC80/RACGAP1/KIF2C/CDT1/NEK2/KNSTRN/HNRNPU 13 GO:0006268 DNA unwinding involved in DNA replication 9/896 15/18722 4.88484741689453e-09 2.15928347854208e-07 MCM7/MCM6/MCM4/RAD51/BLM/MCM2/RPA1/PURA/HMGA1 9 GO:0006271 DNA strand elongation involved in DNA replication 9/896 15/18722 4.88484741689453e-09 2.15928347854208e-07 PCNA/MCM3/RFC3/MCM7/LIG1/MCM4/POLD3/RFC4/POLA1 9 GO:0051303 establishment of chromosome localization 19/896 80/18722 5.00523915298936e-09 2.19220290975882e-07 CENPF/CCNB1/CENPE/DLGAP5/NUF2/KPNB1/AURKB/CDCA8/NDC80/KIF22/CDCA5/KIF2C/CDT1/SPDL1/KIF14/KIF18A/KIFC1/HNRNPU/DYNC1H1 19 GO:1904029 regulation of cyclin-dependent protein kinase activity 21/896 98/18722 5.7665149728944e-09 2.50266749823617e-07 CCNB1/CCNA2/CKS2/EGFR/CKS1B/CDKN3/CCNB2/IPO7/NR2F2/CDC6/PLK1/HERC5/BLM/IPO5/PKMYT1/PKD2/CCNF/CCND1/CDKN2A/CCNE1/HSP90AB1 21 GO:0009314 response to radiation 52/896 456/18722 5.87243508243003e-09 2.52567613365054e-07 PCNA/RRM1/BRCA2/PRKDC/NUCKS1/EGFR/ECT2/APP/MME/PBK/PARP1/SMC1A/BRCA1/USP1/RAD51AP1/ITGB1/FEN1/AURKB/DTL/TOPBP1/CHEK1/MSH6/FANCD2/RAD51/SCARA3/LRP5/POLD3/MSH2/BLM/XRCC2/MEIS2/FIGNL1/RNF168/CCND1/NF1/REV1/CDS1/YAP1/NEDD4/DNMT3A/NET1/UBE4B/IKBIP/HSPA5/TMEM109/FMR1/USP47/HMGN1/XRCC5/ADIRF/XRCC6/DDB1 52 GO:0050000 chromosome localization 19/896 82/18722 7.77351293035444e-09 3.31345988656358e-07 CENPF/CCNB1/CENPE/DLGAP5/NUF2/KPNB1/AURKB/CDCA8/NDC80/KIF22/CDCA5/KIF2C/CDT1/SPDL1/KIF14/KIF18A/KIFC1/HNRNPU/DYNC1H1 19 GO:0061640 cytoskeleton-dependent cytokinesis 21/896 100/18722 8.45936485571728e-09 3.57389449745082e-07 NUSAP1/STMN1/MYH10/ANLN/CKAP2/KIF23/KIF20B/ECT2/AURKB/CEP55/KIF4A/RACGAP1/PLK1/SPTBN1/ANK3/CENPA/KIF20A/CIT/ROCK2/RASA1/SON 21 GO:0000082 G1/S transition of mitotic cell cycle 32/896 214/18722 9.88208684480193e-09 4.13834057869161e-07 NASP/GTSE1/PRKDC/EGFR/CDKN3/EZH2/ITGB1/WEE1/DBF4/CDC6/ADAMTS1/KIF14/RBL1/PKD2/SOX4/DLG1/CCND1/TFDP1/PPAT/CDKN2A/SKP2/CTDSPL/RDX/BRD7/CDK6/CDK2/KHDRBS1/BCAT1/CUL1/CCNE1/EIF4G1/BRD4 32 GO:1901992 positive regulation of mitotic cell cycle phase transition 20/896 93/18722 1.24255600117956e-08 5.13513529708239e-07 CCNB1/UBE2C/CDK1/EGFR/DLGAP5/APP/RAD51C/DTL/FBXO5/CDC6/CDCA5/CDT1/ADAMTS1/CCND1/TFDP1/PBX1/RDX/EIF4G1/ANAPC5/BRD4 20 GO:0051642 centrosome localization 12/896 32/18722 1.24774967419681e-08 5.13513529708239e-07 ASPM/SYNE2/AURKA/DLGAP5/MAD2L1/GPSM2/PARD3/DLG1/DYNC1LI2/AKAP9/RANBP2/KIF5B 12 GO:1903829 positive regulation of cellular protein localization 37/896 276/18722 1.45792378204952e-08 5.94882746624309e-07 CDK1/CDH1/EGFR/ECT2/TCAF1/PARP1/ITGB1/NDC80/PLK1/SPTBN1/CDT1/GPSM2/ANK3/IPO5/DLG1/TPR/FZD5/SLC5A3/ROCK2/YAP1/SAE1/RDX/MYO1C/IQGAP1/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/CD2AP/LRP1/CCT5/CCT6A/CCT2/CCT4/RTN4/HSP90AB1 37 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 20/896 94/18722 1.50834705582927e-08 6.10241427502454e-07 CCNB1/CCNA2/CKS2/EGFR/CKS1B/CDKN3/CCNB2/IPO7/NR2F2/CDC6/PLK1/HERC5/BLM/IPO5/PKMYT1/PKD2/CCNF/CCND1/CDKN2A/CCNE1 20 GO:0061842 microtubule organizing center localization 12/896 33/18722 1.8756417013842e-08 7.52463317849427e-07 ASPM/SYNE2/AURKA/DLGAP5/MAD2L1/GPSM2/PARD3/DLG1/DYNC1LI2/AKAP9/RANBP2/KIF5B 12 GO:0007076 mitotic chromosome condensation 9/896 17/18722 2.17504057639437e-08 8.65303642642225e-07 NUSAP1/SMC4/SMC2/NCAPG/NCAPD2/NCAPD3/PLK1/CDCA5/NCAPH 9 GO:1901989 positive regulation of cell cycle phase transition 22/896 115/18722 2.29432646451446e-08 9.05216077817522e-07 CCNB1/UBE2C/CDK1/EGFR/DLGAP5/ATAD5/APP/EZH2/RAD51C/DTL/FBXO5/CDC6/CDCA5/CDT1/ADAMTS1/CCND1/TFDP1/PBX1/RDX/EIF4G1/ANAPC5/BRD4 22 GO:0034728 nucleosome organization 27/896 167/18722 2.64026815063027e-08 1.03316722550073e-06 HMGB2/NASP/HP1BP3/SUPT16H/CENPW/DNAJC9/ANP32E/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/MIS18A/NAP1L1/SMARCC1/CTCF/SET/SETD2/SMARCA4/RBBP4/BPTF/SMARCA5/ANP32B/ATRX/NAP1L4/HMGA1 27 GO:0006403 RNA localization 30/896 201/18722 2.97612301114298e-08 1.15512286627614e-06 SLBP/XPO1/CKAP5/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/DHX9/SETD2/HNRNPU/KHDRBS1/NCBP3/SRSF7/DCP2/RAN/RANBP2/KHSRP/FMR1/PABPN1/CCT5/CCT6A/CCT2/CCT4 30 GO:0030261 chromosome condensation 14/896 48/18722 3.14706826184466e-08 1.21162128081019e-06 TOP2A/NUSAP1/CCNB1/SMC4/CDK1/SMC2/NCAPG/NCAPD2/NCAPD3/PLK1/CDCA5/NCAPH/NCAPG2/SMC5 14 GO:0010212 response to ionizing radiation 25/896 148/18722 3.53245049984709e-08 1.3491134949016e-06 RRM1/BRCA2/PRKDC/NUCKS1/ECT2/PARP1/BRCA1/RAD51AP1/TOPBP1/FANCD2/RAD51/MSH2/BLM/XRCC2/FIGNL1/RNF168/CCND1/YAP1/DNMT3A/NET1/IKBIP/HSPA5/TMEM109/XRCC5/XRCC6 25 GO:0051382 kinetochore assembly 9/896 18/18722 4.16511857939812e-08 1.57811715063862e-06 CENPF/CENPE/DLGAP5/CENPW/CENPK/CENPN/CENPA/CENPH/KNTC1 9 GO:0044843 cell cycle G1/S phase transition 33/896 241/18722 5.23871520006566e-08 1.96926191851287e-06 NASP/GTSE1/CCNA2/PRKDC/EGFR/CDKN3/EZH2/ITGB1/WEE1/DBF4/CDC6/ADAMTS1/KIF14/RBL1/PKD2/SOX4/DLG1/CCND1/TFDP1/PPAT/CDKN2A/SKP2/CTDSPL/RDX/BRD7/CDK6/CDK2/KHDRBS1/BCAT1/CUL1/CCNE1/EIF4G1/BRD4 33 GO:0007163 establishment or maintenance of cell polarity 31/896 218/18722 5.52045607444158e-08 2.05895760151438e-06 KIF20B/MAD2L1/HSP90AA1/ITGB1/WEE1/NDC80/GJA1/PLK1/AMOT/DST/KANK1/KIF2C/GPSM2/FAT1/SPDL1/PARD3/CKAP5/CENPA/CDK5RAP2/DLG1/FRMD4A/ROCK2/FERMT1/DLG5/AMOTL1/PDLIM1/MPP7/SPINT2/PARD6B/RHOBTB3/HSP90AB1 31 GO:0032465 regulation of cytokinesis 19/896 92/18722 5.73496285277701e-08 2.12238082629128e-06 PRC1/BRCA2/KIF23/KIF20B/ECT2/AURKA/AURKB/RACGAP1/CDC6/PLK1/KIF14/KIF20A/SVIL/CIT/CCP110/CALM2/PKN2/SETD2/PRPF40A 19 GO:1902969 mitotic DNA replication 8/896 14/18722 6.19574941395556e-08 2.27526982324799e-06 BRCA2/MCM3/MCM6/LIG1/MCM4/RAD51/MCM2/POLA1 8 GO:0140013 meiotic nuclear division 28/896 185/18722 6.31710191675197e-08 2.30212553821175e-06 TOP2A/ASPM/SMC4/PTTG1/RAD21/BRCA2/CKS2/SMC2/AURKA/CCNB2/NUF2/CDC20/RAD51AP1/TTK/RAD51C/FBXO5/PLK1/BUB1B/FANCD2/RAD51/MND1/BUB1/KIF18A/NDC1/FIGNL1/RAD50/CALR/CCNE1 28 GO:1904951 positive regulation of establishment of protein localization 39/896 319/18722 7.6157704033413e-08 2.7543702958751e-06 CDK1/MYH10/CDH1/KIF20B/EGFR/ECT2/TCAF1/WLS/GJA1/ANK3/CEP295/CENPJ/IPO5/EXPH5/SOX4/CEP135/TPR/FZD5/CTDSPL2/FRMD4A/PCM1/SAE1/MYO1C/TMEM30B/ICE1/TM7SF3/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/ANP32B/CD2AP/LRP1/CCT5/CCT6A/CCT2/CCT4/HSP90AB1 39 GO:0044774 mitotic DNA integrity checkpoint signaling 18/896 85/18722 8.51288793694079e-08 3.05567872262822e-06 CDK1/GTSE1/PRKDC/CLSPN/BRCA1/DTL/CDC6/PLK1/TOPBP1/CHEK1/FANCD2/MSH2/BLM/MDC1/SOX4/CCND1/NAE1/CDK2 18 GO:0006333 chromatin assembly or disassembly 27/896 177/18722 9.17813286079199e-08 3.26988106547918e-06 HMGB2/HELLS/HMGB1/NASP/HP1BP3/SUPT16H/CENPW/BAZ1B/DNAJC9/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/MIS18A/NAP1L1/SMARCC1/CTCF/SET/SMARCA4/RBBP4/SMARCA5/ANP32B/ATRX/NAP1L4/HMGA1 27 GO:0050684 regulation of mRNA processing 23/896 137/18722 1.3892042949974e-07 4.91263800319821e-06 CCNB1/BARD1/SRSF2/SRPK1/SRSF10/RBMX/MBNL3/AHCYL1/SF1/SRSF4/DHX9/HNRNPU/KHDRBS1/SRSF7/FMR1/RNPS1/THRAP3/TRA2B/RBM25/DDX17/HSPA8/SON/NCL 23 GO:2001020 regulation of response to DNA damage stimulus 30/896 219/18722 2.08347850914328e-07 7.3136223548897e-06 HMGB1/PCNA/DEK/PRKDC/FUS/EGFR/PARP1/BRCA1/RIF1/USP1/RAD51AP1/FBXO5/CHEK1/RAD51/POLQ/RMI2/TIMELESS/FOXM1/WDR76/FANCB/PARPBP/FIGNL1/RNF168/SLF2/DHX9/SETD2/TRIM28/FMR1/USP47/BCLAF1 30 GO:0007063 regulation of sister chromatid cohesion 9/896 21/18722 2.21052888162569e-07 7.6985127591353e-06 RAD21/FEN1/CDCA5/BUB1/SLF2/CTCF/SFPQ/SMC5/ATRX 9 GO:0010833 telomere maintenance via telomere lengthening 17/896 81/18722 2.2253765411828e-07 7.6985127591353e-06 PARP1/HSP90AA1/AURKB/RFC1/RAD51/NEK2/RPA1/HNRNPA2B1/HNRNPU/DCP2/RAD50/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 17 GO:0010569 regulation of double-strand break repair via homologous recombination 13/896 48/18722 2.56935136768566e-07 8.82452045275635e-06 FUS/PARP1/RIF1/RAD51AP1/CHEK1/RAD51/POLQ/RMI2/TIMELESS/FANCB/PARPBP/FIGNL1/SETD2 13 GO:0045739 positive regulation of DNA repair 16/896 73/18722 2.6823528399359e-07 9.08195209776878e-06 HMGB1/PCNA/PRKDC/FUS/EGFR/PARP1/BRCA1/RIF1/RAD51AP1/TIMELESS/FOXM1/FANCB/RNF168/SLF2/DHX9/TRIM28 16 GO:0051298 centrosome duplication 16/896 73/18722 2.6823528399359e-07 9.08195209776878e-06 BRCA2/BRCA1/CEP152/NDC80/XPO1/CKAP5/CEP295/CENPJ/CDK5RAP2/PKD2/CCNF/SASS6/CCP110/CEP135/ROCK2/CDK2 16 GO:0048024 regulation of mRNA splicing, via spliceosome 19/896 101/18722 2.71959506438122e-07 9.143201998138e-06 SRSF2/SRPK1/SRSF10/RBMX/MBNL3/SF1/SRSF4/HNRNPU/KHDRBS1/SRSF7/FMR1/RNPS1/THRAP3/TRA2B/RBM25/DDX17/HSPA8/SON/NCL 19 GO:0015931 nucleobase-containing compound transport 30/896 222/18722 2.8137264242497e-07 9.39351744711054e-06 SLC29A1/SLBP/XPO1/GJA1/SLC35B4/CKAP5/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/SLC25A36/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/SLC35D1/DHX9/SETD2/KHDRBS1/NCBP3/SRSF7/RAN/RANBP2/KHSRP/FMR1/PABPN1/SLC25A5 30 GO:0048511 rhythmic process 36/896 298/18722 3.23101021430597e-07 1.07116963632616e-05 TOP2A/TYMS/CDK1/PCNA/PRKDC/EGFR/EZH2/HNRNPR/DTL/ADAMTS1/TIMELESS/ID4/ADRB1/SLC6A4/ZFHX3/ROCK2/LGR4/SFPQ/HNRNPD/DHX9/HNRNPU/PSPC1/ID1/HSPA5/GFPT1/HUWE1/PLEKHA1/CBX3/HDAC2/USP9X/NONO/MAGED1/THRAP3/SERPINF1/CLDN4/DDB1 36 GO:0045216 cell-cell junction organization 28/896 200/18722 3.34629489109934e-07 1.10173874552471e-05 CDH1/DSP/ECT2/DSG2/PERP/GJA5/GJA1/MARVELD3/SVEP1/PARD3/CNTNAP2/MPDZ/DLG1/FZD5/ROCK2/MARVELD2/RDX/PKN2/DLG5/MYO1C/VCL/CTNND1/MPP7/PARD6B/EPB41L3/LSR/CLDN4/CLDN7 28 GO:0007064 mitotic sister chromatid cohesion 10/896 28/18722 3.57941755035376e-07 1.16276873596995e-05 RAD21/SMC3/CDC20/SMC1A/CDCA5/PDS5B/SLF2/PDS5A/SMC5/ATRX 10 GO:0000727 double-strand break repair via break-induced replication 7/896 12/18722 3.60276583696004e-07 1.16276873596995e-05 MCM3/MCM7/MCM6/MCM4/MCM2/GINS2/MCM5 7 GO:0031570 DNA integrity checkpoint signaling 21/896 123/18722 3.6047292191779e-07 1.16276873596995e-05 CDK1/GTSE1/PRKDC/CLSPN/BRCA1/DTL/CDC6/PLK1/TOPBP1/CHEK1/FANCD2/CDT1/MSH2/BLM/TIMELESS/WDR76/MDC1/SOX4/CCND1/NAE1/CDK2 21 GO:0040001 establishment of mitotic spindle localization 11/896 35/18722 4.11085010034031e-07 1.31110232469504e-05 NUSAP1/MAD2L1/KPNB1/ITGB1/NDC80/GJA1/PLK1/GPSM2/SPDL1/CENPA/CDK5RAP2 11 GO:0032388 positive regulation of intracellular transport 28/896 202/18722 4.11950877051226e-07 1.31110232469504e-05 CDK1/CDH1/KIF20B/ECT2/TCAF1/PGAP1/ANK3/IPO5/TPR/FZD5/CTDSPL2/PCM1/SAE1/RDX/MYO1C/NEDD4/TMEM30B/DHX9/ICE1/DYNC1H1/KHDRBS1/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/ANP32B/HSP90AB1 28 GO:2000779 regulation of double-strand break repair 17/896 85/18722 4.62074383478289e-07 1.46088947465255e-05 DEK/PRKDC/FUS/PARP1/RIF1/RAD51AP1/CHEK1/RAD51/POLQ/RMI2/TIMELESS/FOXM1/FANCB/PARPBP/FIGNL1/SLF2/SETD2 17 GO:2000278 regulation of DNA biosynthetic process 19/896 106/18722 5.94966602971254e-07 1.86866484380577e-05 PCNA/RFC3/HSP90AA1/AURKB/GJA1/RFC4/NEK2/TFDP1/RFC2/HNRNPA2B1/HNRNPD/HNRNPU/DCP2/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 19 GO:0009411 response to UV 23/896 149/18722 6.55762730324969e-07 2.04615115985059e-05 PCNA/BRCA2/EGFR/MME/PBK/PARP1/USP1/FEN1/AURKB/DTL/CHEK1/MSH6/SCARA3/POLD3/MSH2/CCND1/REV1/NEDD4/UBE4B/FMR1/USP47/HMGN1/DDB1 23 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 7/896 13/18722 7.48259968757932e-07 2.31277599415074e-05 CCNB1/ECT2/AURKB/RACGAP1/NEK2/KNSTRN/HNRNPU 7 GO:1902751 positive regulation of cell cycle G2/M phase transition 10/896 30/18722 7.50901296802189e-07 2.31277599415074e-05 CCNB1/CDK1/ATAD5/APP/RAD51C/DTL/FBXO5/CCND1/PBX1/BRD4 10 GO:0050657 nucleic acid transport 24/896 163/18722 9.10191925545517e-07 2.76767914175433e-05 SLBP/XPO1/CKAP5/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/DHX9/SETD2/KHDRBS1/NCBP3/SRSF7/RAN/RANBP2/KHSRP/FMR1/PABPN1 24 GO:0050658 RNA transport 24/896 163/18722 9.10191925545517e-07 2.76767914175433e-05 SLBP/XPO1/CKAP5/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/DHX9/SETD2/KHDRBS1/NCBP3/SRSF7/RAN/RANBP2/KHSRP/FMR1/PABPN1 24 GO:0007623 circadian rhythm 28/896 210/18722 9.17340830112281e-07 2.77176273604812e-05 TOP2A/TYMS/CDK1/PRKDC/EGFR/EZH2/HNRNPR/TIMELESS/ID4/ADRB1/SLC6A4/ZFHX3/ROCK2/LGR4/SFPQ/HNRNPD/HNRNPU/PSPC1/ID1/GFPT1/HUWE1/HDAC2/USP9X/NONO/MAGED1/THRAP3/CLDN4/DDB1 28 GO:0051028 mRNA transport 21/896 130/18722 9.3038711031406e-07 2.79350192744611e-05 SLBP/XPO1/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/DHX9/SETD2/NCBP3/SRSF7/RANBP2/KHSRP/FMR1/PABPN1 21 GO:0090329 regulation of DNA-dependent DNA replication 12/896 46/18722 1.15650756260583e-06 3.45072943992514e-05 PCNA/BRCA2/GMNN/RFC3/DBF4/FBXO5/CDT1/BLM/TIMELESS/RFC4/RFC2/ATRX 12 GO:0044773 mitotic DNA damage checkpoint signaling 16/896 81/18722 1.19347332922149e-06 3.53890787186547e-05 CDK1/GTSE1/PRKDC/CLSPN/BRCA1/DTL/PLK1/TOPBP1/CHEK1/FANCD2/MSH2/BLM/MDC1/SOX4/CCND1/CDK2 16 GO:0030010 establishment of cell polarity 22/896 143/18722 1.21050358603107e-06 3.56724945661255e-05 KIF20B/MAD2L1/HSP90AA1/ITGB1/WEE1/NDC80/GJA1/PLK1/AMOT/KANK1/GPSM2/FAT1/SPDL1/PARD3/CENPA/CDK5RAP2/FRMD4A/ROCK2/FERMT1/AMOTL1/MPP7/HSP90AB1 22 GO:0034501 protein localization to kinetochore 8/896 19/18722 1.25827300121314e-06 3.66280201694606e-05 CDK1/BUB3/AURKB/NDC80/TTK/CDT1/SPDL1/KNTC1 8 GO:1903083 protein localization to condensed chromosome 8/896 19/18722 1.25827300121314e-06 3.66280201694606e-05 CDK1/BUB3/AURKB/NDC80/TTK/CDT1/SPDL1/KNTC1 8 GO:0051236 establishment of RNA localization 24/896 166/18722 1.27251259003512e-06 3.68180309383494e-05 SLBP/XPO1/CKAP5/RANBP17/NDC1/NUP155/NUP107/NUP210/TPR/IGF2BP3/HNRNPA2B1/HNRNPA3/LRPPRC/MYO1C/DHX9/SETD2/KHDRBS1/NCBP3/SRSF7/RAN/RANBP2/KHSRP/FMR1/PABPN1 24 GO:0034504 protein localization to nucleus 34/896 290/18722 1.36342053458106e-06 3.9210660434277e-05 CDK1/KPNA2/CDH1/ECT2/KPNB1/BMP7/PARP1/IPO7/BARD1/XPO1/PLK1/CSE1L/IPO5/RANBP17/NUP155/NUP107/TPR/FERMT1/IPO9/YAP1/TNPO1/TAF3/HNRNPU/TRIM28/CALR/RAN/RANBP2/CD2AP/MAGED1/CCT5/CCT6A/CCT2/CCT4/HSP90AB1 34 GO:0051984 positive regulation of chromosome segregation 7/896 14/18722 1.43456244337631e-06 4.10095874531647e-05 CCNB1/AURKB/CDC6/CDT1/SMC6/HNRNPU/SMC5 7 GO:0006401 RNA catabolic process 33/896 278/18722 1.47474421190171e-06 4.19073146882069e-05 FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/LIN28B/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/PNRC2/HNRNPM 33 GO:0061458 reproductive system development 44/896 427/18722 1.48385626744046e-06 4.19167445015429e-05 HMGB2/ASPM/LRP2/RRM1/NASP/BRCA2/MME/ADGRG1/BMP7/NR2F2/DHCR24/GJA1/CTSV/ITGB8/ADAMTS1/MSH2/KIF18A/PKD2/CCNF/NUP107/DLG1/CCND1/FZD5/SMARCC1/LGR4/PLEKHA5/SF1/SETD2/SPINT1/BPTF/HSPA5/SPINT2/PRDX4/TRIM28/PLEKHA1/ST14/ASH1L/ATRX/RBPJ/ZFX/SERPINF1/RHOBTB3/BSG/HSP90AB1 44 GO:0032886 regulation of microtubule-based process 30/896 240/18722 1.50493483591915e-06 4.22621112157531e-05 STMN1/TPX2/CKAP2/MET/AURKA/BRCA1/XPO1/KLHL42/PLK1/TACC3/GPSM2/CKAP5/CEP295/CENPJ/KIF18A/CDK5RAP2/CCNF/SKA3/MPDZ/KIF15/TPR/SKA2/ROCK2/HNRNPU/DYNC1H1/CAMSAP2/CLIP1/MACF1/AKAP9/CLTC 30 GO:0007043 cell-cell junction assembly 22/896 146/18722 1.73078296170539e-06 4.83202213987224e-05 ECT2/GJA5/GJA1/MARVELD3/PARD3/CNTNAP2/MPDZ/DLG1/FZD5/ROCK2/MARVELD2/PKN2/DLG5/MYO1C/VCL/CTNND1/MPP7/PARD6B/EPB41L3/LSR/CLDN4/CLDN7 22 GO:0051653 spindle localization 13/896 56/18722 1.7638711121871e-06 4.89576784277976e-05 ASPM/NUSAP1/MAD2L1/KPNB1/ITGB1/NDC80/GJA1/PLK1/GPSM2/SPDL1/CENPA/CDK5RAP2/DYNC1H1 13 GO:0010165 response to X-ray 10/896 33/18722 2.02929891350329e-06 5.57563998840338e-05 BRCA2/NUCKS1/RAD51/MSH2/BLM/XRCC2/CCND1/IKBIP/XRCC5/XRCC6 10 GO:1990830 cellular response to leukemia inhibitory factor 17/896 94/18722 2.03217712187304e-06 5.57563998840338e-05 HELLS/NRP2/RIF1/EPS8/MYBL2/GCLM/KLF5/MTF2/HNRNPU/SRSF7/SMARCA5/PCOLCE2/TLE4/CACYBP/XRCC5/NCL/SLC25A5 17 GO:0031055 chromatin remodeling at centromere 6/896 10/18722 2.10290483502945e-06 5.73672438996034e-05 HELLS/NASP/CENPW/ITGB3BP/HJURP/MIS18A 6 GO:2001022 positive regulation of response to DNA damage stimulus 18/896 105/18722 2.29339139995257e-06 6.22082417237133e-05 HMGB1/PCNA/PRKDC/FUS/EGFR/PARP1/BRCA1/RIF1/RAD51AP1/TIMELESS/FOXM1/FANCB/RNF168/SLF2/DHX9/TRIM28/FMR1/BCLAF1 18 GO:1990823 response to leukemia inhibitory factor 17/896 95/18722 2.36627691316044e-06 6.38226326747341e-05 HELLS/NRP2/RIF1/EPS8/MYBL2/GCLM/KLF5/MTF2/HNRNPU/SRSF7/SMARCA5/PCOLCE2/TLE4/CACYBP/XRCC5/NCL/SLC25A5 17 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 7/896 15/18722 2.57851912723582e-06 6.91564624349651e-05 CENPE/NUF2/AURKB/NDC80/KIF2C/CDT1/HNRNPU 7 GO:0046822 regulation of nucleocytoplasmic transport 18/896 106/18722 2.64079647206237e-06 7.04310746236076e-05 CDK1/CDH1/ECT2/BARD1/XPO1/PTPN14/IPO5/TPR/CTDSPL2/FERMT1/NEDD4/DHX9/SETD2/KHDRBS1/TRIM28/RAN/ANP32B/HSP90AB1 18 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 9/896 27/18722 2.7179455662245e-06 7.20859562953097e-05 CCNB1/CDK1/APP/RAD51C/DTL/FBXO5/CCND1/PBX1/BRD4 9 GO:0034724 DNA replication-independent nucleosome organization 10/896 34/18722 2.75210122685917e-06 7.25885704808048e-05 NASP/SUPT16H/CENPW/HAT1/ASF1B/ITGB3BP/HJURP/MIS18A/RBBP4/ATRX 10 GO:0048608 reproductive structure development 43/896 424/18722 2.95178400573443e-06 7.74275650734955e-05 HMGB2/ASPM/LRP2/RRM1/NASP/BRCA2/MME/ADGRG1/BMP7/NR2F2/DHCR24/GJA1/CTSV/ITGB8/ADAMTS1/MSH2/KIF18A/PKD2/CCNF/NUP107/DLG1/CCND1/FZD5/SMARCC1/LGR4/SF1/SETD2/SPINT1/BPTF/HSPA5/SPINT2/PRDX4/TRIM28/PLEKHA1/ST14/ASH1L/ATRX/RBPJ/ZFX/SERPINF1/RHOBTB3/BSG/HSP90AB1 43 GO:0000018 regulation of DNA recombination 18/896 107/18722 3.03504519366641e-06 7.91765341779422e-05 KPNA2/FUS/PARP1/RIF1/RAD51AP1/CHEK1/MSH6/RAD51/POLQ/RMI2/MSH2/BLM/TIMELESS/FANCB/PARPBP/FIGNL1/SETD2/RAD50 18 GO:0031497 chromatin assembly 22/896 151/18722 3.06688623058015e-06 7.93767619080247e-05 HMGB2/HELLS/HMGB1/NASP/HP1BP3/CENPW/DNAJC9/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/MIS18A/NAP1L1/CTCF/SET/RBBP4/SMARCA5/ANP32B/ATRX/NAP1L4 22 GO:0000380 alternative mRNA splicing, via spliceosome 15/896 77/18722 3.07597422559375e-06 7.93767619080247e-05 SRSF2/RBMX/MBNL3/SFPQ/DHX9/HNRNPU/KHDRBS1/FMR1/RNPS1/THRAP3/RBM17/TRA2B/RBM25/DDX17/HNRNPM 15 GO:0006913 nucleocytoplasmic transport 34/896 301/18722 3.15444267690187e-06 8.05310659867888e-05 CDK1/KPNA2/CDH1/ECT2/KPNB1/IPO7/BARD1/XPO1/CSE1L/PTPN14/IPO5/RANBP17/NDC1/NUP155/NUP107/TPR/CTDSPL2/FERMT1/IPO9/HNRNPA2B1/AHCYL1/NEDD4/TNPO1/DHX9/SETD2/KHDRBS1/TRIM28/CALR/RAN/RANBP2/ANP32B/PABPN1/HSPA9/HSP90AB1 34 GO:0051169 nuclear transport 34/896 301/18722 3.15444267690187e-06 8.05310659867888e-05 CDK1/KPNA2/CDH1/ECT2/KPNB1/IPO7/BARD1/XPO1/CSE1L/PTPN14/IPO5/RANBP17/NDC1/NUP155/NUP107/TPR/CTDSPL2/FERMT1/IPO9/HNRNPA2B1/AHCYL1/NEDD4/TNPO1/DHX9/SETD2/KHDRBS1/TRIM28/CALR/RAN/RANBP2/ANP32B/PABPN1/HSPA9/HSP90AB1 34 GO:1900182 positive regulation of protein localization to nucleus 16/896 87/18722 3.21531626603717e-06 8.1648509862029e-05 CDK1/CDH1/ECT2/PARP1/PLK1/IPO5/TPR/YAP1/TRIM28/RAN/CD2AP/CCT5/CCT6A/CCT2/CCT4/HSP90AB1 16 GO:0043297 apical junction assembly 15/896 78/18722 3.64190282105409e-06 9.1991767554033e-05 ECT2/GJA1/MARVELD3/PARD3/DLG1/FZD5/ROCK2/MARVELD2/PKN2/DLG5/MYO1C/VCL/MPP7/CLDN4/CLDN7 15 GO:0006298 mismatch repair 10/896 35/18722 3.68850771358923e-06 9.26786096035526e-05 HMGB1/PCNA/RPA3/LIG1/MSH6/RNASEH2A/POLD3/MSH2/RPA1/SETD2 10 GO:0051293 establishment of spindle localization 12/896 51/18722 3.78329264870218e-06 9.45625084026399e-05 NUSAP1/MAD2L1/KPNB1/ITGB1/NDC80/GJA1/PLK1/GPSM2/SPDL1/CENPA/CDK5RAP2/DYNC1H1 12 GO:0007004 telomere maintenance via telomerase 14/896 69/18722 3.95126808847069e-06 9.77375847376117e-05 HSP90AA1/AURKB/RFC1/NEK2/RPA1/HNRNPU/DCP2/RAD50/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 14 GO:0070192 chromosome organization involved in meiotic cell cycle 14/896 69/18722 3.95126808847069e-06 9.77375847376117e-05 SMC4/RAD21/SMC2/NCAPD2/RAD51C/NCAPD3/BUB1B/FANCD2/RAD51/BUB1/NDC1/RAD50/CCNE1/ATRX 14 GO:0006284 base-excision repair 11/896 43/18722 3.98711154839083e-06 9.81158274846281e-05 HMGB1/PCNA/RPA3/FEN1/LIG1/POLQ/PARP2/RPA1/UNG/HUWE1/USP47 11 GO:0051302 regulation of cell division 24/896 177/18722 4.03345027957451e-06 9.83546079215677e-05 ASPM/PRC1/BRCA2/KIF23/KIF20B/ORC6/ECT2/AURKA/AURKB/RACGAP1/CDC6/PLK1/KIF14/BLM/RBL1/KIF20A/SVIL/CIT/CCP110/CALM2/PKN2/SETD2/NCOA3/PRPF40A 24 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 13/896 60/18722 4.0380190935541e-06 9.83546079215677e-05 CDK1/RAD21/CLSPN/BRCA1/AURKB/DTL/CDC6/PLK1/TOPBP1/CHEK1/BLM/NAE1/USP47 13 GO:0034975 protein folding in endoplasmic reticulum 6/896 11/18722 4.43846149072337e-06 0.000107559467800575 HSP90B1/PDIA3/P4HB/HSPA5/CANX/CALR 6 GO:0120193 tight junction organization 15/896 80/18722 5.05996365878711e-06 0.0001220013459952 ECT2/GJA1/MARVELD3/SVEP1/PARD3/MPDZ/DLG1/FZD5/ROCK2/MARVELD2/MYO1C/MPP7/LSR/CLDN4/CLDN7 15 GO:0033157 regulation of intracellular protein transport 28/896 229/18722 5.13042192541859e-06 0.000123078564180645 CDK1/CDH1/KIF20B/ECT2/TCAF1/LMAN1/BARD1/XPO1/PTPN14/ANK3/IPO5/TPR/FZD5/CTDSPL2/FERMT1/PCM1/SAE1/MYO1C/TMEM30B/ICE1/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/UBE2G2/ANP32B/HSP90AB1 28 GO:0034329 cell junction assembly 42/896 420/18722 5.46543046553431e-06 0.000130459825212304 ITGA6/CDH1/ECT2/APP/LAMC1/NRP1/ITGB4/GJA5/GJA1/MARVELD3/DST/TPBG/CLSTN1/PARD3/CNTNAP2/MPDZ/DLG1/FZD5/ACTN1/NRCAM/ROCK2/MARVELD2/PPP1R9A/PKN2/DLG5/MYO1C/VCL/PLXNB1/RYK/ZDHHC12/CTNND1/IQGAP1/MACF1/MPP7/SLK/PARD6B/EIF4G1/EPB41L3/LRP1/LSR/CLDN4/CLDN7 42 GO:0046824 positive regulation of nucleocytoplasmic transport 13/896 62/18722 5.94211539533872e-06 0.000140433954937362 CDK1/CDH1/ECT2/IPO5/TPR/CTDSPL2/NEDD4/DHX9/KHDRBS1/TRIM28/RAN/ANP32B/HSP90AB1 13 GO:1902750 negative regulation of cell cycle G2/M phase transition 13/896 62/18722 5.94211539533872e-06 0.000140433954937362 CDK1/RAD21/CLSPN/BRCA1/AURKB/DTL/CDC6/PLK1/TOPBP1/CHEK1/BLM/NAE1/USP47 13 GO:0048732 gland development 43/896 436/18722 6.01824689279134e-06 0.000141532564858059 TYMS/PCNA/BRCA2/CDH1/PRKDC/MET/EGFR/AURKA/CCNB2/DAG1/WLS/EZH2/BMP7/SLC29A1/NRP1/LAMA5/LRP5/PKD2/NFIB/CCND1/IGSF3/PBX1/NF1/PPAT/ARHGAP5/COBL/SMARCC1/HNRNPD/PRLR/ASXL1/TFCP2L1/SEC63/TGFBR3/LY6E/ASH1L/PRKCSH/RBPJ/LSR/SERPINF1/TGM2/LMO4/RTN4/SRSF5 43 GO:0043488 regulation of mRNA stability 22/896 158/18722 6.5214093704021e-06 0.000152613766344606 FUS/HNRNPR/MYEF2/EXOSC8/ROCK2/AGO2/CARHSP1/HNRNPD/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/CNOT1/LARP1/SYNCRIP/PUM1/KHSRP/FMR1/SERBP1/THRAP3/HNRNPM 22 GO:0043487 regulation of RNA stability 23/896 170/18722 6.61170220927568e-06 0.000153972030961376 FUS/HNRNPR/MYEF2/EXOSC8/LIN28B/ROCK2/AGO2/CARHSP1/HNRNPD/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/CNOT1/LARP1/SYNCRIP/PUM1/KHSRP/FMR1/SERBP1/THRAP3/HNRNPM 23 GO:0000132 establishment of mitotic spindle orientation 9/896 30/18722 7.28766792533723e-06 0.000168889935318252 MAD2L1/ITGB1/NDC80/GJA1/PLK1/GPSM2/SPDL1/CENPA/CDK5RAP2 9 GO:0070507 regulation of microtubule cytoskeleton organization 21/896 148/18722 7.8009114312892e-06 0.000179910875231762 STMN1/TPX2/CKAP2/MET/PLK1/TACC3/GPSM2/CKAP5/KIF18A/CDK5RAP2/SKA3/MPDZ/KIF15/TPR/SKA2/HNRNPU/DYNC1H1/CAMSAP2/CLIP1/AKAP9/CLTC 21 GO:0090316 positive regulation of intracellular protein transport 22/896 160/18722 8.01501260165508e-06 0.000183959952693756 CDK1/CDH1/KIF20B/ECT2/TCAF1/ANK3/IPO5/TPR/FZD5/CTDSPL2/PCM1/SAE1/MYO1C/TMEM30B/ICE1/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/ANP32B/HSP90AB1 22 GO:0072001 renal system development 33/896 302/18722 8.90442082425385e-06 0.000203395717775062 CENPF/LRP2/FBN1/LGR5/MME/ENPEP/BMP7/NRP1/LAMA5/ADAMTS6/ADAMTS1/FRAS1/PKD2/NUP107/FREM2/SOX4/DLG1/PBX1/NF1/PPAT/YAP1/LGR4/IRX2/AHI1/DLG5/ASXL1/IQGAP1/C1GALT1/TACSTD2/HSPB11/MAGED1/CD24/SERPINF1 33 GO:0120192 tight junction assembly 14/896 74/18722 9.32935553211672e-06 0.000212087349096787 ECT2/GJA1/MARVELD3/PARD3/MPDZ/DLG1/FZD5/ROCK2/MARVELD2/MYO1C/MPP7/LSR/CLDN4/CLDN7 14 GO:0071478 cellular response to radiation 24/896 186/18722 9.57143757299589e-06 0.000216559445371954 PCNA/NUCKS1/ECT2/MME/PBK/PARP1/RAD51AP1/AURKB/CHEK1/RAD51/POLD3/BLM/FIGNL1/YAP1/NEDD4/NET1/HSPA5/TMEM109/FMR1/USP47/XRCC5/ADIRF/XRCC6/DDB1 24 GO:0006457 protein folding 26/896 212/18722 1.04535481911096e-05 0.000235402071058289 HSP90B1/PDIA6/HSP90AA1/LMAN1/PDIA4/PPIC/NKTR/CCDC47/PDIA3/P4HB/HSPA5/PRDX4/CANX/CALR/RANBP2/HSPD1/HSPA9/PPIG/DNAJB11/CCT5/HSPA8/CCT6A/CCT2/CCT4/ERP29/HSP90AB1 26 GO:0016572 histone phosphorylation 10/896 39/18722 1.073049220196e-05 0.000240504083437356 CCNB1/CDK1/CCNA2/AURKA/BAZ1B/AURKB/CHEK1/VRK1/CDK2/FMR1 10 GO:0006278 RNA-dependent DNA biosynthetic process 14/896 75/18722 1.09716037884374e-05 0.000244759049000001 HSP90AA1/AURKB/RFC1/NEK2/RPA1/HNRNPU/DCP2/RAD50/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 14 GO:0006334 nucleosome assembly 19/896 129/18722 1.21348187065366e-05 0.000269449416302352 HMGB2/NASP/HP1BP3/CENPW/DNAJC9/HAT1/ASF1B/MCM2/CHAF1A/ITGB3BP/HJURP/MIS18A/NAP1L1/SET/RBBP4/SMARCA5/ANP32B/ATRX/NAP1L4 19 GO:2000573 positive regulation of DNA biosynthetic process 13/896 66/18722 1.22500726429645e-05 0.000269617147434922 PCNA/RFC3/HSP90AA1/AURKB/RFC4/NEK2/RFC2/CCT5/XRCC5/CCT6A/CCT2/CCT4/HSP90AB1 13 GO:0001822 kidney development 32/896 293/18722 1.22553248834055e-05 0.000269617147434922 CENPF/LRP2/FBN1/MME/ENPEP/BMP7/NRP1/LAMA5/ADAMTS6/ADAMTS1/FRAS1/PKD2/NUP107/FREM2/SOX4/DLG1/PBX1/NF1/PPAT/YAP1/LGR4/IRX2/AHI1/DLG5/ASXL1/IQGAP1/C1GALT1/TACSTD2/HSPB11/MAGED1/CD24/SERPINF1 32 GO:0031589 cell-substrate adhesion 37/896 363/18722 1.28050002602643e-05 0.000280417757993127 ITGA6/LAMB1/DAG1/LAMC1/ITGAV/ITGB1/NRP1/LAMA5/BCAM/ITGB4/KANK1/KIF14/EMP2/GCNT2/UTRN/NF1/ACTN1/ROCK2/FERMT1/CDKN2A/ITGB5/FBLN1/CDK6/VCL/CCDC80/ID1/IQGAP1/P4HB/MACF1/SLK/TRPM7/CALR/TACSTD2/LRP1/PPFIA1/TRIOBP/RASA1 37 GO:0006611 protein export from nucleus 12/896 57/18722 1.29363549736876e-05 0.000282000724403583 BARD1/XPO1/CSE1L/PTPN14/RANBP17/TPR/CTDSPL2/AHCYL1/CALR/RAN/ANP32B/HSPA9 12 GO:0061013 regulation of mRNA catabolic process 22/896 166/18722 1.45380944882552e-05 0.000315476650395139 FUS/HNRNPR/MYEF2/EXOSC8/ROCK2/AGO2/CARHSP1/HNRNPD/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/CNOT1/LARP1/SYNCRIP/PUM1/KHSRP/FMR1/SERBP1/THRAP3/HNRNPM 22 GO:0032386 regulation of intracellular transport 35/896 337/18722 1.46199403492398e-05 0.000315817172974077 CDK1/CDH1/KIF20B/ECT2/TCAF1/LMAN1/BARD1/XPO1/PGAP1/PTPN14/ANK3/IPO5/TPR/FZD5/CTDSPL2/FERMT1/PCM1/SAE1/RDX/MYO1C/NEDD4/TMEM30B/DHX9/SETD2/ICE1/DYNC1H1/KHDRBS1/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/UBE2G2/ANP32B/HSP90AB1 35 GO:0001655 urogenital system development 35/896 338/18722 1.55794706604569e-05 0.000335028796995592 CENPF/HELLS/LRP2/FBN1/LGR5/MME/ENPEP/BMP7/NRP1/LAMA5/ADAMTS6/ADAMTS1/FRAS1/PKD2/NUP107/FREM2/SOX4/DLG1/PBX1/NF1/PPAT/YAP1/SMARCC1/LGR4/IRX2/AHI1/DLG5/ASXL1/IQGAP1/C1GALT1/TACSTD2/HSPB11/MAGED1/CD24/SERPINF1 35 GO:0007568 aging 35/896 339/18722 1.6596351969484e-05 0.000355295893732361 TYMS/CDK1/BRCA2/PRKDC/ATP2B1/APP/MME/DAG1/RPN2/AURKB/FBXO5/CTSV/CHEK1/MSH6/COL4A2/PAWR/MSH2/FOXM1/RBL1/SMC6/GCLM/CDKN2A/PPP1R9A/CDK6/DNMT3A/CDK2/TFCP2L1/SEC63/SMC5/CANX/CALR/LRP1/SERPINF1/CACYBP/HMGA1 35 GO:0006336 DNA replication-independent nucleosome assembly 9/896 33/18722 1.72586703163307e-05 0.000367825411116798 NASP/CENPW/HAT1/ASF1B/ITGB3BP/HJURP/MIS18A/RBBP4/ATRX 9 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 40/896 412/18722 1.82066168391556e-05 0.000386303950178351 UBE2C/UBE2S/AURKA/HSP90B1/PBK/CDC20/XPO1/KLHL42/PLK1/KIF14/CCNF/PSMD1/STT3B/SKP2/SMARCC1/NEDD4/CDK2/CCDC47/NHLRC3/TBL1X/ASCC3/FBXO22/UBE4B/HSPA5/RNF217/CANX/HUWE1/CALR/CUL1/UBE2G2/ANAPC5/UBXN4/CD2AP/USP14/UFL1/PSMD7/PSMD14/DDB1/RAD23B/HSP90AB1 40 GO:0006402 mRNA catabolic process 27/896 232/18722 1.86483702616732e-05 0.000393926193049681 FUS/HNRNPR/MYEF2/EXOSC8/ROCK2/AGO2/CARHSP1/HNRNPD/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/PNRC2/HNRNPM 27 GO:0016032 viral process 40/896 415/18722 2.15238826704968e-05 0.000452665268145161 TOP2A/CDK1/DEK/KPNA2/NUCKS1/EGFR/HACD3/DAG1/ITGAV/DPP4/ITGB1/NRP1/FUT8/ROCK2/CD46/SRPK1/ILF3/PKN2/ITGB5/EIF3A/NEDD4/DHX9/SMARCA4/P4HB/SLC1A5/TRIM28/CANX/EEA1/RAN/SIVA1/LARP1/LY6E/FMR1/ANO6/HTATSF1/HSPA8/DDB1/CTSL/BSG/HSP90AB1 40 GO:0032467 positive regulation of cytokinesis 10/896 42/18722 2.17968719080463e-05 0.000456395905653565 KIF23/KIF20B/ECT2/AURKB/RACGAP1/CDC6/KIF14/SVIL/CIT/PKN2 10 GO:0032204 regulation of telomere maintenance 14/896 80/18722 2.36332250285464e-05 0.00049268566063878 PARP1/AURKB/NEK2/HNRNPA2B1/HNRNPD/HNRNPU/DCP2/RAD50/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 14 GO:0051222 positive regulation of protein transport 32/896 303/18722 2.41260227430109e-05 0.000500772315544061 CDK1/MYH10/CDH1/KIF20B/EGFR/ECT2/TCAF1/WLS/GJA1/ANK3/IPO5/EXPH5/SOX4/TPR/FZD5/CTDSPL2/FRMD4A/PCM1/SAE1/MYO1C/TMEM30B/ICE1/TM7SF3/TRIM28/NPEPPS/HUWE1/RAN/KIF5B/ANP32B/CD2AP/LRP1/HSP90AB1 32 GO:0019058 viral life cycle 33/896 317/18722 2.42807771471313e-05 0.00050180272770738 TOP2A/CDK1/DEK/KPNA2/NUCKS1/EGFR/HACD3/DAG1/ITGAV/DPP4/ITGB1/NRP1/ROCK2/CD46/SRPK1/ILF3/PKN2/ITGB5/NEDD4/P4HB/SLC1A5/TRIM28/EEA1/SIVA1/LARP1/LY6E/FMR1/HTATSF1/HSPA8/DDB1/CTSL/BSG/HSP90AB1 33 GO:0000212 meiotic spindle organization 6/896 14/18722 2.54807890070208e-05 0.000524333132411712 ASPM/AURKA/CCNB2/FBXO5/TUBG1/ATRX 6 GO:0051656 establishment of organelle localization 38/896 390/18722 2.70685531181907e-05 0.000554614903803616 CENPF/NUSAP1/CCNB1/SYNE2/CENPE/DLGAP5/MAD2L1/NUF2/KPNB1/ITGB1/AURKB/CDCA8/NDC80/XPO1/GJA1/ARHGAP21/PLK1/KIF22/CDCA5/KIF2C/CDT1/GPSM2/SPDL1/PARD3/KIF14/CENPA/KIF18A/KIFC1/CDK5RAP2/DLG1/PCM1/LRPPRC/MYO1C/HNRNPU/DYNC1H1/RAN/KIF5B/TRIP11 38 GO:0032206 positive regulation of telomere maintenance 11/896 52/18722 2.82226207346245e-05 0.000575789706782467 AURKB/NEK2/HNRNPA2B1/HNRNPD/RAD50/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 11 GO:0060236 regulation of mitotic spindle organization 9/896 35/18722 2.89861408529466e-05 0.000588850367795604 TPX2/PLK1/TACC3/GPSM2/KIF15/TPR/HNRNPU/DYNC1H1/CLTC 9 GO:1903312 negative regulation of mRNA metabolic process 15/896 92/18722 2.92496514231464e-05 0.000591685745313987 FUS/BARD1/SRSF10/RBMX/HNRNPD/SRSF4/DHX9/HNRNPU/TAF15/SRSF7/LARP1/SYNCRIP/FMR1/RNPS1/THRAP3 15 GO:0000077 DNA damage checkpoint signaling 17/896 115/18722 3.28055946565616e-05 0.000660818180972258 CDK1/GTSE1/PRKDC/CLSPN/BRCA1/DTL/PLK1/TOPBP1/CHEK1/FANCD2/MSH2/BLM/WDR76/MDC1/SOX4/CCND1/CDK2 17 GO:0000722 telomere maintenance via recombination 6/896 15/18722 4.07489689268773e-05 0.000817376376709715 BRCA2/RAD51C/RAD51/SMC6/SMC5/RAD50 6 GO:0051960 regulation of nervous system development 41/896 443/18722 4.35622801315019e-05 0.000870151988902888 HMGB2/ASPM/LRP2/EGFR/MME/DAG1/EZH2/BMP7/NRP1/SEMA6D/TPBG/CLSTN1/PARD3/PRTG/KIF14/XRCC2/SEMA6A/DLG1/YWHAH/NF1/NAP1L1/YAP1/DICER1/PCM1/DLG5/PLXNB1/RYK/GOLGA4/ID1/SPINT1/MACF1/HDAC2/LRP1/ETV5/UFL1/SERPINF1/XRCC5/IDH2/TGM2/RHEB/RTN4 41 GO:0051294 establishment of spindle orientation 9/896 37/18722 4.68554272563528e-05 0.000932032540507617 MAD2L1/ITGB1/NDC80/GJA1/PLK1/GPSM2/SPDL1/CENPA/CDK5RAP2 9 GO:2000045 regulation of G1/S transition of mitotic cell cycle 19/896 142/18722 4.78870389893718e-05 0.00094860051508407 GTSE1/PRKDC/EGFR/EZH2/WEE1/CDC6/ADAMTS1/KIF14/RBL1/PKD2/SOX4/DLG1/CCND1/TFDP1/CTDSPL/RDX/BRD7/CDK2/EIF4G1 19 GO:0044818 mitotic G2/M transition checkpoint 10/896 46/18722 5.07520718685863e-05 0.00100119996322575 CDK1/CLSPN/BRCA1/DTL/CDC6/PLK1/TOPBP1/CHEK1/BLM/NAE1 10 GO:0016570 histone modification 42/896 463/18722 5.59432684061059e-05 0.00109906651592901 CCNB1/CDK1/BRCA2/CCNA2/AURKA/EZH2/BRCA1/RIF1/SUZ12/BAZ1B/AURKB/CHEK1/VRK1/HAT1/NCAPG2/PARP2/RNF168/MTF2/DNMT1/CTCF/YEATS4/SFPQ/BRD7/BRD8/SET/USP22/ASXL1/CDK2/SETD2/TBL1X/ZNF451/PAXBP1/HUWE1/FMR1/HDAC2/ASH1L/BRD4/ATRX/UFL1/NCOA3/DDB1/EID1 42 GO:0071214 cellular response to abiotic stimulus 33/896 331/18722 5.75119838140912e-05 0.00112066208460601 PCNA/NUCKS1/EGFR/ECT2/MME/DAG1/PBK/PARP1/RAD51AP1/AURKB/GJA1/CHEK1/RAD51/ATP1A1/POLD3/BLM/CASP8AP2/PKD2/FIGNL1/YAP1/NEDD4/SLC38A2/NET1/HSPA5/TMEM109/TMEM150C/FMR1/SLC2A1/USP47/XRCC5/ADIRF/XRCC6/DDB1 33 GO:0104004 cellular response to environmental stimulus 33/896 331/18722 5.75119838140912e-05 0.00112066208460601 PCNA/NUCKS1/EGFR/ECT2/MME/DAG1/PBK/PARP1/RAD51AP1/AURKB/GJA1/CHEK1/RAD51/ATP1A1/POLD3/BLM/CASP8AP2/PKD2/FIGNL1/YAP1/NEDD4/SLC38A2/NET1/HSPA5/TMEM109/TMEM150C/FMR1/SLC2A1/USP47/XRCC5/ADIRF/XRCC6/DDB1 33 GO:0001890 placenta development 19/896 144/18722 5.8147289308535e-05 0.00112843560633718 MME/BMP7/NR2F2/GJA1/CTSV/ITGB8/PKD2/CCNF/FZD5/SETD2/SPINT1/BPTF/SPINT2/TRIM28/ST14/ASH1L/RBPJ/BSG/HSP90AB1 19 GO:0010332 response to gamma radiation 11/896 56/18722 5.84089930588656e-05 0.00112892523426326 BRCA2/PRKDC/PARP1/FANCD2/RAD51/XRCC2/YAP1/HSPA5/TMEM109/XRCC5/XRCC6 11 GO:0090231 regulation of spindle checkpoint 6/896 16/18722 6.25616455959387e-05 0.00119467718430005 CCNB1/MAD2L1/NDC80/CDT1/CDK5RAP2/TPR 6 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 6/896 16/18722 6.25616455959387e-05 0.00119467718430005 CCNB1/MAD2L1/NDC80/CDT1/CDK5RAP2/TPR 6 GO:1903504 regulation of mitotic spindle checkpoint 6/896 16/18722 6.25616455959387e-05 0.00119467718430005 CCNB1/MAD2L1/NDC80/CDT1/CDK5RAP2/TPR 6 GO:0034655 nucleobase-containing compound catabolic process 38/896 407/18722 6.81715562423675e-05 0.00129661756773332 DUT/FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/LIN28B/NUDT15/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/UNG/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/HINT1/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/NUDT4/PNRC2/HNRNPM 38 GO:0031109 microtubule polymerization or depolymerization 17/896 122/18722 7.057252237981e-05 0.00133695722952862 STMN1/TPX2/CKAP2/MET/FBXO5/KIF2C/CKAP5/CENPJ/KIF18A/CDK5RAP2/SKA3/SKA2/TUBG1/MZT1/CAMSAP2/CLIP1/AKAP9 17 GO:0050767 regulation of neurogenesis 35/896 364/18722 7.26531559598081e-05 0.0013709334646329 HMGB2/ASPM/LRP2/EGFR/MME/DAG1/EZH2/BMP7/NRP1/SEMA6D/PRTG/XRCC2/SEMA6A/YWHAH/NF1/NAP1L1/YAP1/DICER1/PCM1/PLXNB1/RYK/GOLGA4/ID1/SPINT1/MACF1/HDAC2/LRP1/ETV5/UFL1/SERPINF1/XRCC5/IDH2/TGM2/RHEB/RTN4 35 GO:0090224 regulation of spindle organization 9/896 39/18722 7.3234229782212e-05 0.00137645753141843 TPX2/PLK1/TACC3/GPSM2/KIF15/TPR/HNRNPU/DYNC1H1/CLTC 9 GO:0042770 signal transduction in response to DNA damage 21/896 172/18722 7.69283947930677e-05 0.00144022022251806 CDK1/GTSE1/BRCA2/PRKDC/CLSPN/BRCA1/DTL/PLK1/TOPBP1/CHEK1/FANCD2/MSH2/BLM/FOXM1/WDR76/MDC1/SOX4/CCND1/CDK2/USP10/ATRX 21 GO:0061982 meiosis I cell cycle process 18/896 135/18722 7.86520400240748e-05 0.00146135694965813 TOP2A/PTTG1/RAD21/BRCA2/CKS2/AURKA/CCNB2/RAD51AP1/RAD51C/FBXO5/PLK1/MSH6/FANCD2/RAD51/MND1/NDC1/RAD50/CCNE1 18 GO:0071168 protein localization to chromatin 8/896 31/18722 7.86696137541137e-05 0.00146135694965813 RAD21/EZH2/PLK1/CDCA5/MSH2/ESCO2/MCM8/SETD2 8 GO:1900180 regulation of protein localization to nucleus 18/896 136/18722 8.6675521688194e-05 0.00160383310286604 CDK1/CDH1/ECT2/PARP1/PLK1/IPO5/TPR/FERMT1/YAP1/TRIM28/RAN/CD2AP/MAGED1/CCT5/CCT6A/CCT2/CCT4/HSP90AB1 18 GO:0045740 positive regulation of DNA replication 9/896 40/18722 9.05189592599391e-05 0.00166206735194981 CDK1/PCNA/EGFR/ATAD5/DBF4/CDT1/DHX9/ATRX/CACYBP 9 GO:2000781 positive regulation of double-strand break repair 9/896 40/18722 9.05189592599391e-05 0.00166206735194981 PRKDC/FUS/PARP1/RIF1/RAD51AP1/TIMELESS/FOXM1/FANCB/SLF2 9 GO:0051258 protein polymerization 30/896 296/18722 9.14772857714415e-05 0.001673228207942 STMN1/TPX2/UBE2C/DIAPH3/UBE2S/MET/IQGAP2/HSP90AA1/FBXO5/SPTBN1/KANK1/KANK4/CKAP5/CENPJ/EPS8/CDK5RAP2/SVIL/DLG1/TUBG1/MZT1/COBL/PPP1R9A/RDX/MYO1C/CAMSAP2/CLIP1/ADD3/AKAP9/TRIOBP/RASA1 30 GO:0000076 DNA replication checkpoint signaling 6/896 17/18722 9.27796328269482e-05 0.00169057239357195 CLSPN/CDC6/TOPBP1/CDT1/TIMELESS/NAE1 6 GO:0051494 negative regulation of cytoskeleton organization 20/896 162/18722 9.67759410303996e-05 0.00175668571284839 STMN1/TPX2/CKAP2/MET/BRCA1/SPTBN1/KANK1/KANK4/EPS8/CDK5RAP2/SVIL/CCNF/PPP1R9A/RDX/CAMSAP2/ADD3/TACSTD2/LIMA1/PPFIA1/TRIOBP 20 GO:0010498 proteasomal protein catabolic process 43/896 490/18722 9.7834167592479e-05 0.00176916786396399 UBE2C/UBE2S/AURKA/HSP90B1/PBK/CDC20/XPO1/KLHL42/PLK1/KIF14/CCNF/PSMD1/NUDT15/STT3B/SKP2/SMARCC1/TMTC3/NEDD4/CDK2/CCDC47/NHLRC3/TBL1X/ASCC3/FBXO22/UBE4B/HSPA5/RNF217/CANX/HUWE1/CALR/CUL1/FMR1/UBE2G2/ANAPC5/UBXN4/CD2AP/USP14/UFL1/PSMD7/PSMD14/DDB1/RAD23B/HSP90AB1 43 GO:0070830 bicellular tight junction assembly 12/896 70/18722 0.000109863427439017 0.00197920000978818 ECT2/GJA1/MARVELD3/PARD3/DLG1/FZD5/ROCK2/MARVELD2/MYO1C/MPP7/CLDN4/CLDN7 12 GO:0007099 centriole replication 9/896 41/18722 0.000111099047115639 0.00199393552981225 BRCA1/CEP152/CEP295/CENPJ/CDK5RAP2/SASS6/CCP110/CEP135/CDK2 9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 11/896 60/18722 0.000112889534505666 0.00201848178925112 SRSF2/RBMX/MBNL3/HNRNPU/KHDRBS1/FMR1/RNPS1/THRAP3/TRA2B/RBM25/DDX17 11 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 8/896 33/18722 0.000127169455335168 0.00226532455138095 CCNB1/CKS2/EGFR/CKS1B/CDC6/PKD2/CCND1/HSP90AB1 8 GO:0045132 meiotic chromosome segregation 14/896 93/18722 0.000130609909046337 0.00231796173155097 TOP2A/SMC4/PTTG1/RAD21/SMC2/NUF2/TTK/RAD51C/PLK1/BUB1B/FANCD2/BUB1/NDC1/CCNE1 14 GO:1904356 regulation of telomere maintenance via telomere lengthening 11/896 61/18722 0.000131847600692214 0.00233126091001715 PARP1/AURKB/NEK2/HNRNPA2B1/HNRNPU/DCP2/CCT5/XRCC5/CCT6A/CCT2/CCT4 11 GO:0007127 meiosis I 17/896 129/18722 0.000142385293041928 0.00250829294827366 TOP2A/PTTG1/RAD21/BRCA2/CKS2/AURKA/CCNB2/RAD51AP1/RAD51C/FBXO5/PLK1/FANCD2/RAD51/MND1/NDC1/RAD50/CCNE1 17 GO:0051168 nuclear export 19/896 154/18722 0.000144544977078905 0.00253697691387754 BARD1/XPO1/CSE1L/PTPN14/RANBP17/NUP155/NUP107/TPR/CTDSPL2/HNRNPA2B1/AHCYL1/DHX9/SETD2/KHDRBS1/CALR/RAN/ANP32B/PABPN1/HSPA9 19 GO:0071479 cellular response to ionizing radiation 12/896 72/18722 0.00014532590074872 0.0025413401105289 NUCKS1/ECT2/RAD51AP1/RAD51/BLM/FIGNL1/YAP1/NET1/HSPA5/TMEM109/XRCC5/XRCC6 12 GO:0051255 spindle midzone assembly 5/896 12/18722 0.000148340128924403 0.00257518463812763 PRC1/KIF23/AURKB/KIF4A/RACGAP1 5 GO:0072711 cellular response to hydroxyurea 5/896 12/18722 0.000148340128924403 0.00257518463812763 RAD51/BLM/TIMELESS/FMR1/ATRX 5 GO:0006606 protein import into nucleus 19/896 155/18722 0.00015750907994841 0.00271745077146462 CDK1/KPNA2/CDH1/ECT2/KPNB1/IPO7/CSE1L/IPO5/RANBP17/NUP155/NUP107/TPR/FERMT1/IPO9/TNPO1/TRIM28/RAN/RANBP2/HSP90AB1 19 GO:1903313 positive regulation of mRNA metabolic process 16/896 118/18722 0.000158194316930543 0.00271745077146462 CCNB1/HNRNPR/EXOSC8/ROCK2/AGO2/RBMX/HNRNPD/TNRC6A/DCP2/CNOT1/PUM1/KHSRP/THRAP3/TRA2B/HSPA8/NCL 16 GO:0010810 regulation of cell-substrate adhesion 24/896 221/18722 0.000158423741706247 0.00271745077146462 ITGA6/DAG1/NRP1/KANK1/EMP2/GCNT2/UTRN/NF1/ROCK2/FERMT1/CDKN2A/FBLN1/CDK6/VCL/CCDC80/IQGAP1/P4HB/MACF1/SLK/CALR/TACSTD2/LRP1/TRIOBP/RASA1 24 GO:0007095 mitotic G2 DNA damage checkpoint signaling 8/896 34/18722 0.000159381276918746 0.00271745077146462 CDK1/CLSPN/BRCA1/DTL/PLK1/TOPBP1/CHEK1/BLM 8 GO:0086004 regulation of cardiac muscle cell contraction 8/896 34/18722 0.000159381276918746 0.00271745077146462 DSP/DSG2/GJA5/ATP1A1/DLG1/ATP2A2/DSC2/AKAP9 8 GO:0060669 embryonic placenta morphogenesis 7/896 26/18722 0.000165931368391257 0.00281906175338028 BMP7/FZD5/SETD2/SPINT1/SPINT2/TRIM28/ST14 7 GO:0001763 morphogenesis of a branching structure 22/896 196/18722 0.000182634992413437 0.00309184203468705 MET/DAG1/BMP7/NRP1/LAMA5/LRP5/PKD2/DLG1/FZD5/PBX1/YAP1/LGR4/RERE/DLG5/SETD2/SPINT1/SPINT2/ST14/TACSTD2/MAGED1/TGM2/RTN4 22 GO:0042752 regulation of circadian rhythm 16/896 121/18722 0.00021263542611346 0.00358700185252882 TOP2A/CDK1/PRKDC/EZH2/TIMELESS/ADRB1/ZFHX3/ROCK2/SFPQ/HNRNPD/PSPC1/USP9X/NONO/MAGED1/THRAP3/DDB1 16 GO:0098901 regulation of cardiac muscle cell action potential 7/896 27/18722 0.000214818818013607 0.00361107407463718 DSP/DSG2/GJA5/DLG1/ATP2A2/DSC2/AKAP9 7 GO:0051170 import into nucleus 19/896 159/18722 0.000220148093114106 0.00368767367202365 CDK1/KPNA2/CDH1/ECT2/KPNB1/IPO7/CSE1L/IPO5/RANBP17/NUP155/NUP107/TPR/FERMT1/IPO9/TNPO1/TRIM28/RAN/RANBP2/HSP90AB1 19 GO:0071241 cellular response to inorganic substance 24/896 226/18722 0.00022269454725953 0.00371728590425523 CCNB1/CCNA2/CDH1/FUS/EGFR/ECT2/APP/PARP1/RAD51/ANK3/BLM/TIMELESS/PKD2/MT2A/MTR/HNRNPD/CDK2/IQGAP1/HSPA5/CALR/FMR1/ATRX/SERPINF1/CACYBP 24 GO:0072710 response to hydroxyurea 5/896 13/18722 0.000231568169916601 0.00382528181031783 RAD51/BLM/TIMELESS/FMR1/ATRX 5 GO:1900115 extracellular regulation of signal transduction 5/896 13/18722 0.000231568169916601 0.00382528181031783 FBN2/FBN1/LTBP1/CD46/LRPAP1 5 GO:1900116 extracellular negative regulation of signal transduction 5/896 13/18722 0.000231568169916601 0.00382528181031783 FBN2/FBN1/LTBP1/CD46/LRPAP1 5 GO:0035272 exocrine system development 9/896 45/18722 0.000236688226176324 0.00388298828785488 DAG1/WLS/BMP7/NRP1/LAMA5/NFIB/IGSF3/TFCP2L1/TGM2 9 GO:0098534 centriole assembly 9/896 45/18722 0.000236688226176324 0.00388298828785488 BRCA1/CEP152/CEP295/CENPJ/CDK5RAP2/SASS6/CCP110/CEP135/CDK2 9 GO:0010232 vascular transport 13/896 88/18722 0.000272381349390373 0.00445324849996452 LRP2/SLC29A1/SLC38A1/GJA1/SLC16A1/SLC5A3/SLC16A12/SLC38A2/SLC44A1/SLC1A5/LRP1/SLC2A1/SLC13A3 13 GO:0031122 cytoplasmic microtubule organization 10/896 56/18722 0.000287497100024153 0.00468433841472801 KPNB1/DST/CENPJ/DLG1/TUBG1/PCM1/DYNC1H1/CAMSAP2/CLIP1/SLK 10 GO:0072594 establishment of protein localization to organelle 37/896 422/18722 0.000298171970827505 0.00482911415215825 CDK1/KPNA2/BRCA2/CDH1/ECT2/KPNB1/HSP90AA1/LMAN1/IPO7/CSE1L/IPO5/RANBP17/NUP155/NUP107/TPR/FZD5/FERMT1/IPO9/VPS13A/SAE1/NEDD4/TNPO1/TRAM2/SEC63/HSPA5/TRIM28/NPEPPS/HUWE1/RAN/RANBP2/HSPD1/CCT5/HSPA8/CCT6A/CCT2/CCT4/HSP90AB1 37 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 8/896 37/18722 0.000298405671321048 0.00482911415215825 AURKB/NEK2/HNRNPA2B1/CCT5/XRCC5/CCT6A/CCT2/CCT4 8 GO:0051972 regulation of telomerase activity 9/896 47/18722 0.000334065005389199 0.00538792680989202 HSP90AA1/AURKB/NEK2/HNRNPA2B1/HNRNPD/XRCC5/CCT2/CCT4/HSP90AB1 9 GO:0031145 anaphase-promoting complex-dependent catabolic process 6/896 21/18722 0.000345069751070029 0.00547127631924475 UBE2C/UBE2S/CDC20/PLK1/CDK2/ANAPC5 6 GO:0045056 transcytosis 6/896 21/18722 0.000345069751070029 0.00547127631924475 LRP2/IGF1R/MAL2/LRP1/LRPAP1/CLTC 6 GO:0006999 nuclear pore organization 5/896 14/18722 0.000346061159310811 0.00547127631924475 NDC1/NUP107/TPR/TMEM170A/RTN4 5 GO:0007100 mitotic centrosome separation 5/896 14/18722 0.000346061159310811 0.00547127631924475 AURKA/KIF11/CHEK1/NEK2/RANBP1 5 GO:0007143 female meiotic nuclear division 7/896 29/18722 0.00034725528377276 0.00547127631924475 TOP2A/AURKA/CCNB2/TTK/RAD51C/FBXO5/PLK1 7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 7/896 29/18722 0.00034725528377276 0.00547127631924475 CCNB1/CKS2/EGFR/CKS1B/CDC6/PKD2/CCND1 7 GO:0070198 protein localization to chromosome, telomeric region 7/896 29/18722 0.00034725528377276 0.00547127631924475 BRCA2/ATRX/CCT5/XRCC5/CCT6A/CCT2/CCT4 7 GO:0051261 protein depolymerization 15/896 114/18722 0.000350099681569345 0.00549794697306596 STMN1/TPX2/CKAP2/SPTBN1/KIF2C/CKAP5/EPS8/KIF18A/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP/HSPA8 15 GO:0017038 protein import 22/896 206/18722 0.000369880443897629 0.00578953848907306 CDK1/KPNA2/CDH1/ECT2/KPNB1/HSP90AA1/IPO7/CSE1L/IPO5/RANBP17/NUP155/NUP107/TPR/FERMT1/IPO9/TNPO1/TRIM28/RAN/RANBP2/HSPD1/HSPA8/HSP90AB1 22 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 9/896 48/18722 0.000393926326289605 0.00614576562649208 PCNA/BRCA2/NUCKS1/MMS22L/RAD51/BLM/TIMELESS/ZGRF1/ATRX 9 GO:0046700 heterocycle catabolic process 38/896 445/18722 0.000417204464609843 0.00648773327051268 DUT/FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/LIN28B/NUDT15/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/UNG/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/HINT1/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/NUDT4/PNRC2/HNRNPM 38 GO:0006979 response to oxidative stress 38/896 446/18722 0.000435701225361255 0.00672818017109935 CDK1/PCNA/MET/EGFR/ECT2/APP/EZH2/BMP7/PARP1/DHFR/PSIP1/DHCR24/GPX8/PAWR/SCARA3/MELK/PKD2/MYEF2/FUT8/NUDT15/ATP2A2/GCLM/SFPQ/CYB5B/PDLIM1/NET1/PON2/P4HB/OXR1/PRDX4/PLEKHA1/HSPD1/STK24/HDAC2/ETV5/NONO/TRA2B/HNRNPM 38 GO:0036297 interstrand cross-link repair 8/896 39/18722 0.000436894816305153 0.00672818017109935 NUCKS1/RAD51AP1/MSH6/FANCD2/RAD51/FANCB/MCM8/RNF168 8 GO:1903115 regulation of actin filament-based movement 8/896 39/18722 0.000436894816305153 0.00672818017109935 DSP/DSG2/GJA5/ATP1A1/DLG1/ATP2A2/DSC2/AKAP9 8 GO:1902806 regulation of cell cycle G1/S phase transition 19/896 168/18722 0.000445660314934206 0.00684110078294501 GTSE1/PRKDC/EGFR/EZH2/WEE1/CDC6/ADAMTS1/KIF14/RBL1/PKD2/SOX4/DLG1/CCND1/TFDP1/CTDSPL/RDX/BRD7/CDK2/EIF4G1 19 GO:0060968 regulation of gene silencing 12/896 81/18722 0.000451153187476066 0.00690322216990621 EGFR/TPR/LIN28B/AGO2/DNMT1/KCNQ1OT1/DHX9/CDK2/TRIM28/PUM1/EIF4G1/FMR1 12 GO:0043486 histone exchange 6/896 22/18722 0.000455389926814669 0.00694578757384418 NASP/CENPW/ANP32E/ITGB3BP/HJURP/MIS18A 6 GO:0045185 maintenance of protein location 13/896 93/18722 0.000472678203198968 0.00716370076848213 FBN2/FBN1/BARD1/GJA1/ANK3/PKD2/LTBP1/VPS13A/GPAA1/TAF3/HNRNPU/HSPA5/GOPC 13 GO:0060993 kidney morphogenesis 13/896 93/18722 0.000472678203198968 0.00716370076848213 BMP7/LAMA5/FRAS1/PKD2/SOX4/DLG1/PBX1/LGR4/IRX2/AHI1/ASXL1/TACSTD2/MAGED1 13 GO:0032984 protein-containing complex disassembly 23/896 224/18722 0.000482969495843713 0.0072965075099933 STMN1/TPX2/CKAP2/SUPT16H/SPTBN1/IGF1R/KIF2C/CKAP5/EPS8/KIF18A/SVIL/ATP2A2/SMARCC1/RDX/SET/SMARCA4/CAMSAP2/ADD3/KIF5B/LIMA1/TRIOBP/HSPA8/HMGA1 23 GO:0009263 deoxyribonucleotide biosynthetic process 5/896 15/18722 0.000498717254502779 0.00739402538197598 TYMS/RRM1/DUT/DTYMK/RRM2 5 GO:0051299 centrosome separation 5/896 15/18722 0.000498717254502779 0.00739402538197598 AURKA/KIF11/CHEK1/NEK2/RANBP1 5 GO:0098760 response to interleukin-7 5/896 15/18722 0.000498717254502779 0.00739402538197598 HMGB1/PDIA3/P4HB/HSPD1/RAD23B 5 GO:0098761 cellular response to interleukin-7 5/896 15/18722 0.000498717254502779 0.00739402538197598 HMGB1/PDIA3/P4HB/HSPD1/RAD23B 5 GO:1905168 positive regulation of double-strand break repair via homologous recombination 5/896 15/18722 0.000498717254502779 0.00739402538197598 FUS/PARP1/RAD51AP1/TIMELESS/FANCB 5 GO:2000104 negative regulation of DNA-dependent DNA replication 5/896 15/18722 0.000498717254502779 0.00739402538197598 BRCA2/GMNN/FBXO5/BLM/TIMELESS 5 GO:0031297 replication fork processing 8/896 40/18722 0.000523488780566455 0.00773726141927015 PCNA/BRCA2/NUCKS1/MMS22L/RAD51/BLM/ZGRF1/ATRX 8 GO:0044270 cellular nitrogen compound catabolic process 38/896 451/18722 0.000539579298843008 0.00795046781690284 DUT/FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/LIN28B/NUDT15/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/UNG/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/TNRC6A/DCP2/HINT1/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/NUDT4/PNRC2/HNRNPM 38 GO:0019439 aromatic compound catabolic process 39/896 467/18722 0.000545189063652819 0.0080084079688571 DUT/FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/LIN28B/NUDT15/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/UNG/HNRNPD/LRPPRC/DHX9/HNRNPU/PON2/TAF15/TNRC6A/DCP2/HINT1/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/NUDT4/PNRC2/HNRNPM 39 GO:0071900 regulation of protein serine/threonine kinase activity 32/896 359/18722 0.000561400283343343 0.0082212421861384 CCNB1/CCNA2/CKS2/EGFR/CKS1B/CDKN3/CCNB2/EZH2/BMP7/IPO7/DBF4/NR2F2/CDC6/PLK1/HERC5/LRP5/BLM/IPO5/PKMYT1/PKD2/CCNF/CCND1/FZD5/CALM2/NF1/CDKN2A/IQGAP1/CCNE1/MAGED1/CD24/ERP29/HSP90AB1 32 GO:0046785 microtubule polymerization 12/896 83/18722 0.000566126543914767 0.00826510128638868 STMN1/TPX2/MET/FBXO5/CKAP5/CENPJ/CDK5RAP2/TUBG1/MZT1/CAMSAP2/CLIP1/AKAP9 12 GO:0007569 cell aging 16/896 132/18722 0.000574163796292951 0.00835688403506874 CDK1/BRCA2/PRKDC/MME/FBXO5/CHEK1/PAWR/FOXM1/RBL1/SMC6/CDKN2A/CDK6/CDK2/SMC5/CALR/HMGA1 16 GO:0061351 neural precursor cell proliferation 17/896 145/18722 0.000577834172321016 0.00838474267070069 ASPM/LRP2/RRM1/ADGRG1/RACGAP1/SHCBP1/KIF14/MELK/SLC6A4/NF1/NAP1L1/FZD6/RERE/PCM1/RYK/SPINT1/SPINT2 17 GO:0018279 protein N-linked glycosylation via asparagine 6/896 23/18722 0.000591362406400278 0.00852919676179736 RPN2/FUT8/STT3B/TUSC3/RPN1/DDOST 6 GO:1904666 regulation of ubiquitin protein ligase activity 6/896 23/18722 0.000591362406400278 0.00852919676179736 UBE2C/UBE2S/MAD2L1/CDC20/FBXO5/PLK1 6 GO:0048675 axon extension 15/896 120/18722 0.000609256406757112 0.00876081351162185 NRP2/HSP90AA1/ITGB1/NRP1/SEMA6D/SEMA6A/NRCAM/VCL/RYK/GOLGA4/MACF1/LRP1/USP9X/RTN4/HSP90AB1 15 GO:0042307 positive regulation of protein import into nucleus 8/896 41/18722 0.000623462049281805 0.0088974067115257 CDK1/CDH1/ECT2/IPO5/TPR/TRIM28/RAN/HSP90AB1 8 GO:0071634 regulation of transforming growth factor beta production 8/896 41/18722 0.000623462049281805 0.0088974067115257 ITGAV/ITGB8/LTBP1/CD46/FERMT1/CD2AP/CD24/HSP90AB1 8 GO:0006997 nucleus organization 16/896 133/18722 0.000624346721483266 0.0088974067115257 HMGB2/CDK1/PLK1/CHEK1/VRK1/NDC1/NUP155/NUP107/TPR/TMEM170A/SRPK1/ANKLE2/SF1/SMARCA5/SERBP1/RTN4 16 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 12/896 84/18722 0.0006322634401184 0.00898340971168227 GTSE1/PRKDC/EZH2/WEE1/RBL1/PKD2/SOX4/DLG1/CCND1/CTDSPL/BRD7/CDK2 12 GO:0008156 negative regulation of DNA replication 7/896 32/18722 0.000660699641549254 0.00935958483310427 BRCA2/GMNN/FBXO5/CDC6/BLM/TIMELESS/PDS5A 7 GO:0098727 maintenance of cell number 16/896 134/18722 0.000678231191682955 0.00957951393223204 ASPM/SMC3/EZH2/BMP7/SMC1A/RIF1/LRP5/SOX4/ZC3H13/YAP1/MTF2/PCM1/SMC5/CNOT1/RBPJ/NCOA3 16 GO:0006266 DNA ligation 5/896 16/18722 0.000696969804005888 0.00978627601271797 TOP2A/HMGB1/LIG1/RAD51/XRCC6 5 GO:0070200 establishment of protein localization to telomere 5/896 16/18722 0.000696969804005888 0.00978627601271797 BRCA2/CCT5/CCT6A/CCT2/CCT4 5 GO:0018196 peptidyl-asparagine modification 6/896 24/18722 0.000756835543542558 0.0105956976095958 RPN2/FUT8/STT3B/TUSC3/RPN1/DDOST 6 GO:1904589 regulation of protein import 10/896 63/18722 0.000762979104108324 0.0106504743947753 CDK1/CDH1/ECT2/IPO5/TPR/FERMT1/TRIM28/RAN/HSPA8/HSP90AB1 10 GO:1901976 regulation of cell cycle checkpoint 7/896 33/18722 0.000804342383991506 0.0111951327731063 CCNB1/MAD2L1/NDC80/CDT1/WDR76/CDK5RAP2/TPR 7 GO:0007160 cell-matrix adhesion 23/896 233/18722 0.000834831899903908 0.0115654722974407 DAG1/ITGAV/ITGB1/NRP1/BCAM/ITGB4/EMP2/UTRN/NF1/ACTN1/ROCK2/FERMT1/CDKN2A/ITGB5/CDK6/VCL/IQGAP1/MACF1/SLK/TRPM7/LRP1/PPFIA1/RASA1 23 GO:0007566 embryo implantation 9/896 53/18722 0.000840640738837853 0.0115654722974407 ITGB4/GJA1/EMP2/AGO2/FBLN1/PRLR/TRIM28/CALR/BSG 9 GO:0032210 regulation of telomere maintenance via telomerase 9/896 53/18722 0.000840640738837853 0.0115654722974407 AURKB/NEK2/HNRNPU/DCP2/CCT5/XRCC5/CCT6A/CCT2/CCT4 9 GO:0032784 regulation of DNA-templated transcription, elongation 9/896 53/18722 0.000840640738837853 0.0115654722974407 EZH2/SUPT16H/TCERG1/RNF168/ZNF326/HNRNPU/BRD4/HTATSF1/HMGN1 9 GO:0033314 mitotic DNA replication checkpoint signaling 4/896 10/18722 0.00086777008970125 0.0117423519968282 CLSPN/CDC6/TOPBP1/NAE1 4 GO:0036363 transforming growth factor beta activation 4/896 10/18722 0.00086777008970125 0.0117423519968282 ITGAV/ITGB8/LTBP1/HSP90AB1 4 GO:1904668 positive regulation of ubiquitin protein ligase activity 4/896 10/18722 0.00086777008970125 0.0117423519968282 UBE2C/UBE2S/CDC20/PLK1 4 GO:1904851 positive regulation of establishment of protein localization to telomere 4/896 10/18722 0.00086777008970125 0.0117423519968282 CCT5/CCT6A/CCT2/CCT4 4 GO:0071604 transforming growth factor beta production 8/896 43/18722 0.000869527674398028 0.0117423519968282 ITGAV/ITGB8/LTBP1/CD46/FERMT1/CD2AP/CD24/HSP90AB1 8 GO:1904591 positive regulation of protein import 8/896 43/18722 0.000869527674398028 0.0117423519968282 CDK1/CDH1/ECT2/IPO5/TPR/TRIM28/RAN/HSP90AB1 8 GO:0150104 transport across blood-brain barrier 12/896 87/18722 0.000870714831771511 0.0117423519968282 LRP2/SLC29A1/SLC38A1/SLC16A1/SLC5A3/SLC16A12/SLC38A2/SLC44A1/SLC1A5/LRP1/SLC2A1/SLC13A3 12 GO:0043588 skin development 25/896 263/18722 0.000879357351156309 0.0118254985758316 STMN1/ITGA6/DSP/MET/EGFR/LGR5/LAMA5/ITGB4/DHCR24/FRAS1/EXPH5/FZD6/ROCK2/FERMT1/YAP1/LGR4/PALLD/COL5A2/ST14/HDAC2/ASH1L/RBPJ/LSR/NCOA3/CLDN4 25 GO:1901361 organic cyclic compound catabolic process 40/896 495/18722 0.000882716427278247 0.0118373264714223 DUT/FUS/HNRNPR/FEN1/RNASEH2A/MYEF2/EXOSC8/YWHAH/LIN28B/NUDT15/ROCK2/AGO2/DICER1/KCNQ1OT1/CARHSP1/UNG/HNRNPD/LRPPRC/DHX9/HNRNPU/STS/TAF15/TNRC6A/DCP2/HINT1/CNOT1/LARP1/LSM5/SYNCRIP/PUM1/KHSRP/LSM4/FMR1/SERBP1/RNPS1/THRAP3/LSM2/NUDT4/PNRC2/HNRNPM 40 GO:0048863 stem cell differentiation 21/896 206/18722 0.000915002593178667 0.01223591703035 PRKDC/NRP2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A/MSI2/YAP1/MTF2/SETD2/HNRNPU/PUM1/TACSTD2/HSPA9/RBPJ/UFL1/XRCC5/PSMD11/OCIAD1 21 GO:0051053 negative regulation of DNA metabolic process 15/896 125/18722 0.000935967697767909 0.0124775812715735 PARP1/RIF1/GJA1/MSH6/POLQ/RMI2/MSH2/BLM/FANCB/PARPBP/HNRNPU/DCP2/TRIM28/RAD50/XRCC5 15 GO:0031100 animal organ regeneration 11/896 76/18722 0.000940915219473497 0.0124775812715735 TYMS/CDK1/PCNA/CCNA2/EGFR/AURKA/EZH2/CCND1/PPAT/TGFBR3/SRSF5 11 GO:0086001 cardiac muscle cell action potential 11/896 76/18722 0.000940915219473497 0.0124775812715735 DSP/DSG2/GJA5/GJA1/ATP1A1/ANK3/NUP155/DLG1/ATP2A2/DSC2/AKAP9 11 GO:0006312 mitotic recombination 6/896 25/18722 0.00095590523022313 0.0126063303013404 BRCA2/RAD51C/RAD51/SMC6/SMC5/RAD50 6 GO:0090169 regulation of spindle assembly 6/896 25/18722 0.00095590523022313 0.0126063303013404 PLK1/GPSM2/KIF15/TPR/HNRNPU/DYNC1H1 6 GO:0007431 salivary gland development 7/896 34/18722 0.000971554522862226 0.0127074008003952 DAG1/BMP7/NRP1/LAMA5/NFIB/TFCP2L1/TGM2 7 GO:0032212 positive regulation of telomere maintenance via telomerase 7/896 34/18722 0.000971554522862226 0.0127074008003952 AURKB/NEK2/CCT5/XRCC5/CCT6A/CCT2/CCT4 7 GO:0051973 positive regulation of telomerase activity 7/896 34/18722 0.000971554522862226 0.0127074008003952 HSP90AA1/AURKB/NEK2/XRCC5/CCT2/CCT4/HSP90AB1 7 GO:0048524 positive regulation of viral process 10/896 65/18722 0.00098054092343625 0.0127898971816521 TOP2A/KPNA2/HACD3/SRPK1/PKN2/DHX9/P4HB/LARP1/FMR1/DDB1 10 GO:1902904 negative regulation of supramolecular fiber organization 18/896 166/18722 0.0010224502271158 0.0133002108562693 STMN1/TPX2/CKAP2/MET/SPTBN1/KANK1/KANK4/EPS8/SVIL/PPP1R9A/RDX/CAMSAP2/ADD3/TACSTD2/LIMA1/PPFIA1/TRIOBP/HSPA8 18 GO:0002200 somatic diversification of immune receptors 11/896 77/18722 0.00105119404332665 0.0136369575077212 HMGB2/HMGB1/PRKDC/RIF1/MSH6/POLQ/MSH2/RNF168/UNG/HSPD1/CTNNBL1 11 GO:0007292 female gamete generation 16/896 140/18722 0.00109212373778839 0.0141295358379452 TOP2A/ASPM/CCNB1/BRCA2/AURKA/CCNB2/LGR5/TTK/RAD51C/FBXO5/PLK1/ADAMTS1/MCM8/HEXB/USP9X/ZFX 16 GO:0006303 double-strand break repair via nonhomologous end joining 10/896 66/18722 0.0011069906149263 0.014283170799076 HMGB2/HMGB1/DEK/PRKDC/RIF1/POLQ/POLA1/XRCC5/XRCC6/PSMD14 10 GO:0000731 DNA synthesis involved in DNA repair 7/896 35/18722 0.00116493893538025 0.0149500496707133 PCNA/RFC3/DTL/POLD3/POLA1/REV1/USP10 7 GO:0097421 liver regeneration 7/896 35/18722 0.00116493893538025 0.0149500496707133 TYMS/PCNA/EGFR/AURKA/EZH2/CCND1/SRSF5 7 GO:0061138 morphogenesis of a branching epithelium 19/896 182/18722 0.00118651965932723 0.0151637970554757 MET/DAG1/BMP7/NRP1/LAMA5/LRP5/PKD2/DLG1/FZD5/PBX1/YAP1/LGR4/DLG5/SPINT1/SPINT2/ST14/TACSTD2/MAGED1/TGM2 19 GO:0045910 negative regulation of DNA recombination 8/896 45/18722 0.00118794723476077 0.0151637970554757 RIF1/MSH6/POLQ/RMI2/MSH2/BLM/FANCB/PARPBP 8 GO:0001952 regulation of cell-matrix adhesion 15/896 128/18722 0.00119535903730567 0.0152177174509261 DAG1/NRP1/EMP2/UTRN/NF1/ROCK2/FERMT1/CDKN2A/CDK6/VCL/IQGAP1/MACF1/SLK/LRP1/RASA1 15 GO:0018205 peptidyl-lysine modification 32/896 376/18722 0.00121733909828626 0.0154563214234538 BRCA2/EZH2/BRCA1/RIF1/SUZ12/CHEK1/HAT1/PLOD2/SOX4/MTF2/DNMT1/SAE1/CTCF/YEATS4/BRD7/BRD8/SET/USP22/SETD2/SMC5/ZNF451/HINT1/TRIM28/RANBP2/UBA2/HDAC2/ASH1L/BRD4/ATRX/NCOA3/TGM2/EID1 32 GO:1902117 positive regulation of organelle assembly 10/896 67/18722 0.00124645256985294 0.0157839908978194 GPSM2/CEP295/CENPJ/CCP110/CEP135/G3BP1/DYNC1H1/CNOT1/ATMIN/ASAP1 10 GO:0006337 nucleosome disassembly 5/896 18/18722 0.00126224037822884 0.0158577251728012 SUPT16H/SMARCC1/SET/SMARCA4/HMGA1 5 GO:1900006 positive regulation of dendrite development 5/896 18/18722 0.00126224037822884 0.0158577251728012 EZH2/BMP7/COBL/VLDLR/IQGAP1 5 GO:1904872 regulation of telomerase RNA localization to Cajal body 5/896 18/18722 0.00126224037822884 0.0158577251728012 DCP2/CCT5/CCT6A/CCT2/CCT4 5 GO:0072006 nephron development 16/896 142/18722 0.00127066869992221 0.0159217122662169 ENPEP/BMP7/LAMA5/PKD2/NUP107/DLG1/PBX1/YAP1/LGR4/IRX2/AHI1/ASXL1/IQGAP1/TACSTD2/MAGED1/CD24 16 GO:0006354 DNA-templated transcription, elongation 12/896 91/18722 0.00130112823375585 0.0160622359821495 EZH2/SUPT16H/CDCA4/CHEK1/TCERG1/RNF168/ZNF326/SETD2/HNRNPU/BRD4/HTATSF1/HMGN1 12 GO:0035404 histone-serine phosphorylation 4/896 11/18722 0.00131216422979436 0.0160622359821495 CCNB1/AURKA/AURKB/VRK1 4 GO:0035581 sequestering of extracellular ligand from receptor 4/896 11/18722 0.00131216422979436 0.0160622359821495 FBN2/FBN1/LTBP1/CD46 4 GO:0051657 maintenance of organelle location 4/896 11/18722 0.00131216422979436 0.0160622359821495 ASPM/ARHGAP21/GPSM2/AKAP9 4 GO:0070203 regulation of establishment of protein localization to telomere 4/896 11/18722 0.00131216422979436 0.0160622359821495 CCT5/CCT6A/CCT2/CCT4 4 GO:0071679 commissural neuron axon guidance 4/896 11/18722 0.00131216422979436 0.0160622359821495 DAG1/NRP1/NFIB/RYK 4 GO:0098935 dendritic transport 4/896 11/18722 0.00131216422979436 0.0160622359821495 SFPQ/HNRNPU/KIF5B/PURA 4 GO:1904869 regulation of protein localization to Cajal body 4/896 11/18722 0.00131216422979436 0.0160622359821495 CCT5/CCT6A/CCT2/CCT4 4 GO:1904871 positive regulation of protein localization to Cajal body 4/896 11/18722 0.00131216422979436 0.0160622359821495 CCT5/CCT6A/CCT2/CCT4 4 GO:0071559 response to transforming growth factor beta 24/896 256/18722 0.00133491290719082 0.0162989110458542 FBN2/FBN1/PARP1/COL4A2/ITGB8/LTBP1/FUT8/GCNT2/ZFHX3/ROCK2/FERMT1/ITGB5/GLG1/PEG10/TRIM33/ID1/ZNF451/HSPA5/TGFBR3/NREP/YES1/HDAC2/USP9X/HSP90AB1 24 GO:0031099 regeneration 20/896 198/18722 0.00134042237378993 0.016324429623656 TYMS/CCNB1/CDK1/PCNA/CCNA2/EGFR/AURKA/DAG1/EZH2/DHFR/CCND1/MTR/PPAT/KLF5/YAP1/TGFBR3/NREP/STK24/LRP1/SRSF5 20 GO:0051017 actin filament bundle assembly 17/896 157/18722 0.00141504913117113 0.0171274262903418 STMN1/MET/HSP90B1/NRP1/PAWR/EPS8/ACTN1/ROCK2/PPP1R9A/RDX/ITGB5/ID1/PDLIM1/CALD1/TACSTD2/LIMA1/PPFIA1 17 GO:0043254 regulation of protein-containing complex assembly 35/896 427/18722 0.00141625857590929 0.0171274262903418 STMN1/HMGB1/MET/PARP1/IQGAP2/HSP90AA1/SPTBN1/KANK1/CDT1/KANK4/CKAP5/KIF14/EPS8/HJURP/CDK5RAP2/SVIL/DLG1/SLF2/FERMT1/PPP1R9A/RDX/MYO1C/ICE1/CAMSAP2/CLIP1/ADD3/MPP7/HSPA5/AKAP9/EIF4G1/ASAP1/TRIOBP/HSPA8/RASA1/LMO4 35 GO:0022411 cellular component disassembly 36/896 443/18722 0.00141712052465124 0.0171274262903418 TOP2A/STMN1/TPX2/CDK1/CKAP2/LAMC1/SUPT16H/DPP4/PLK1/CTSV/SPTBN1/IGF1R/VRK1/KIF2C/CKAP5/EPS8/KIF18A/SVIL/FZD5/ATP2A2/SMARCC1/DICER1/RDX/SET/SMARCA4/CAMSAP2/ADD3/HUWE1/KIF5B/LRP1/LIMA1/UFL1/TRIOBP/HSPA8/HMGA1/SLC25A5 36 GO:0032970 regulation of actin filament-based process 33/896 396/18722 0.00146013462584296 0.0176027341004401 STMN1/DSP/MET/ECT2/DSG2/IQGAP2/NRP1/GJA5/SPTBN1/KANK1/ATP1A1/KANK4/EPS8/SVIL/DLG1/ATP2A2/DSC2/ROCK2/PPP1R9A/RDX/MYO1C/ID1/IQGAP1/ADD3/AKAP9/TACSTD2/CD2AP/LRP1/LIMA1/PPFIA1/TRIOBP/RHOBTB3/RASA1 33 GO:0010586 miRNA metabolic process 6/896 27/18722 0.00147234840898957 0.0177052677695622 LIN28B/AGO2/DICER1/KCNQ1OT1/KHSRP/DDX17 6 GO:0040029 regulation of gene expression, epigenetic 13/896 105/18722 0.00150269622144838 0.0180248034200868 HELLS/EZH2/BRCA1/CDCA4/CHEK1/TPR/DNMT1/CTCF/DNMT3A/HNRNPU/TRIM28/SMARCA5/CREBZF 13 GO:0019079 viral genome replication 15/896 131/18722 0.001512743989055 0.0180545995093714 TOP2A/DEK/NUCKS1/HACD3/ROCK2/SRPK1/ILF3/PKN2/TRIM28/EEA1/LARP1/FMR1/HTATSF1/HSPA8/DDB1 15 GO:0019827 stem cell population maintenance 15/896 131/18722 0.001512743989055 0.0180545995093714 ASPM/SMC3/BMP7/SMC1A/RIF1/LRP5/SOX4/ZC3H13/YAP1/MTF2/PCM1/SMC5/CNOT1/RBPJ/NCOA3 15 GO:1902807 negative regulation of cell cycle G1/S phase transition 12/896 93/18722 0.00157477405433052 0.0187480581929524 GTSE1/PRKDC/EZH2/WEE1/RBL1/PKD2/SOX4/DLG1/CCND1/CTDSPL/BRD7/CDK2 12 GO:0009416 response to light stimulus 28/896 320/18722 0.00159356452792808 0.0189245697918623 PCNA/BRCA2/EGFR/APP/MME/PBK/PARP1/USP1/ITGB1/FEN1/AURKB/DTL/CHEK1/MSH6/SCARA3/POLD3/MSH2/MEIS2/CCND1/NF1/REV1/CDS1/NEDD4/UBE4B/FMR1/USP47/HMGN1/DDB1 28 GO:0033120 positive regulation of RNA splicing 7/896 37/18722 0.00164128971890092 0.0192614630135132 RBMX/SLC38A2/THRAP3/TRA2B/HSPA8/NCL/SRSF5 7 GO:0090670 RNA localization to Cajal body 5/896 19/18722 0.00164614095297725 0.0192614630135132 DCP2/CCT5/CCT6A/CCT2/CCT4 5 GO:0090671 telomerase RNA localization to Cajal body 5/896 19/18722 0.00164614095297725 0.0192614630135132 DCP2/CCT5/CCT6A/CCT2/CCT4 5 GO:0090672 telomerase RNA localization 5/896 19/18722 0.00164614095297725 0.0192614630135132 DCP2/CCT5/CCT6A/CCT2/CCT4 5 GO:0090685 RNA localization to nucleus 5/896 19/18722 0.00164614095297725 0.0192614630135132 DCP2/CCT5/CCT6A/CCT2/CCT4 5 GO:2000042 negative regulation of double-strand break repair via homologous recombination 5/896 19/18722 0.00164614095297725 0.0192614630135132 RIF1/POLQ/RMI2/FANCB/PARPBP 5 GO:0061326 renal tubule development 12/896 94/18722 0.00172840306086239 0.0201745628668877 LGR5/LAMA5/PKD2/DLG1/PBX1/YAP1/LGR4/IRX2/AHI1/TACSTD2/MAGED1/CD24 12 GO:0001892 embryonic placenta development 11/896 82/18722 0.00177443426701659 0.0206613394896029 BMP7/NR2F2/PKD2/FZD5/SETD2/SPINT1/BPTF/SPINT2/TRIM28/ST14/RBPJ 11 GO:0007229 integrin-mediated signaling pathway 13/896 107/18722 0.00178640283025553 0.0207500902959609 ITGA6/ITGAV/ITGB1/NRP1/LAMA5/ITGB4/DST/ITGB8/ADAMTS1/FUT8/EMP2/FERMT1/ITGB5 13 GO:0006304 DNA modification 14/896 120/18722 0.00179298498491352 0.0207759959174202 HELLS/EZH2/PARP1/BRCA1/PARP2/MIS18A/DNMT1/CTCF/UNG/DNMT3A/ASCC3/TRIM28/USP9X/ATRX 14 GO:0001889 liver development 16/896 147/18722 0.00182757935274227 0.0211255782808514 TYMS/PCNA/MET/EGFR/AURKA/EZH2/PKD2/CCND1/NF1/COBL/HNRNPD/SEC63/TGFBR3/PRKCSH/LSR/SRSF5 16 GO:0061572 actin filament bundle organization 17/896 161/18722 0.00185990305605093 0.0213773150428077 STMN1/MET/HSP90B1/NRP1/PAWR/EPS8/ACTN1/ROCK2/PPP1R9A/RDX/ITGB5/ID1/PDLIM1/CALD1/TACSTD2/LIMA1/PPFIA1 17 GO:0052126 movement in host environment 18/896 175/18722 0.00186428094206848 0.0213773150428077 CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/NRP1/CD46/ITGB5/P4HB/SLC1A5/TRIM28/SIVA1/LY6E/FUCA2/DDB1/CTSL/BSG 18 GO:0009886 post-embryonic animal morphogenesis 4/896 12/18722 0.00189407628022935 0.0213773150428077 EFEMP1/FBN1/ATRX/HMGN1 4 GO:0046831 regulation of RNA export from nucleus 4/896 12/18722 0.00189407628022935 0.0213773150428077 TPR/DHX9/SETD2/KHDRBS1 4 GO:0070202 regulation of establishment of protein localization to chromosome 4/896 12/18722 0.00189407628022935 0.0213773150428077 CCT5/CCT6A/CCT2/CCT4 4 GO:0098911 regulation of ventricular cardiac muscle cell action potential 4/896 12/18722 0.00189407628022935 0.0213773150428077 DSP/DSG2/DLG1/DSC2 4 GO:1903405 protein localization to nuclear body 4/896 12/18722 0.00189407628022935 0.0213773150428077 CCT5/CCT6A/CCT2/CCT4 4 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 4/896 12/18722 0.00189407628022935 0.0213773150428077 CCT5/CCT6A/CCT2/CCT4 4 GO:1904867 protein localization to Cajal body 4/896 12/18722 0.00189407628022935 0.0213773150428077 CCT5/CCT6A/CCT2/CCT4 4 GO:0007044 cell-substrate junction assembly 12/896 95/18722 0.00189413579034513 0.0213773150428077 ITGA6/LAMC1/NRP1/ITGB4/DST/ACTN1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 12 GO:0033674 positive regulation of kinase activity 37/896 467/18722 0.0019107975725414 0.0215144990832846 CCNB1/TPX2/HMGB1/CKS2/MET/CENPE/EGFR/CKS1B/ECT2/DAG1/EZH2/CLSPN/HSP90AA1/DBF4/CDC6/IGF1R/KIF14/PKD2/EMP2/DLG1/CCND1/FZD5/CALM2/VLDLR/PPP1R9A/PRLR/RYK/IQGAP1/RAD50/RANBP2/MAGED1/CD24/XRCC5/XRCC6/LMO4/ERP29/HSP90AB1 37 GO:0060562 epithelial tube morphogenesis 28/896 325/18722 0.00200023470466211 0.0224685187766045 LRP2/KIF20B/MET/LGR5/DAG1/BMP7/NRP1/LAMA5/LRP5/PKD2/SOX4/DLG1/PBX1/FZD6/YAP1/COBL/LGR4/IRX2/AHI1/DLG5/SETD2/SPINT1/SPINT2/ST14/TACSTD2/MAGED1/RBPJ/LMO4 28 GO:0035825 homologous recombination 9/896 60/18722 0.00208133652046908 0.0230830572577427 TOP2A/RAD21/NUCKS1/RAD51AP1/RAD51C/FANCD2/RAD51/MND1/RAD50 9 GO:0042306 regulation of protein import into nucleus 9/896 60/18722 0.00208133652046908 0.0230830572577427 CDK1/CDH1/ECT2/IPO5/TPR/FERMT1/TRIM28/RAN/HSP90AB1 9 GO:0002064 epithelial cell development 21/896 220/18722 0.00208350299258515 0.0230830572577427 TYMS/ADAMTSL4/MET/FAT1/EXPH5/KLF5/ROCK2/YAP1/MARVELD2/PALLD/RDX/CDK6/ASXL1/VCL/TFCP2L1/IQGAP1/SPINT2/ST14/ATRX/TRIOBP/RHEB 21 GO:0031503 protein-containing complex localization 21/896 220/18722 0.00208350299258515 0.0230830572577427 BIRC5/DAG1/XPO1/CLSTN1/NDC1/NUP155/NUP107/DLG1/TPR/MZT1/PCM1/HNRNPA2B1/SFPQ/SETD2/HNRNPU/AKAP9/RAN/KIF5B/PURA/HSPB11/PABPN1 21 GO:0051235 maintenance of location 28/896 326/18722 0.00209146370589778 0.0230830572577427 ASPM/FBN2/FBN1/HSP90B1/ITGAV/MCOLN3/BARD1/GJA1/ARHGAP21/GPSM2/ANK3/PKD2/LTBP1/CALM2/CDS1/VPS13A/GPAA1/ASXL1/TAF3/MEST/HNRNPU/HSPA5/AKAP9/CALR/GOPC/SQLE/HEXB/HILPDA 28 GO:0046605 regulation of centrosome cycle 8/896 49/18722 0.00210018396856977 0.0230830572577427 AURKA/BRCA1/XPO1/CEP295/CENPJ/CDK5RAP2/CCNF/ROCK2 8 GO:0060964 regulation of gene silencing by miRNA 8/896 49/18722 0.00210018396856977 0.0230830572577427 EGFR/LIN28B/AGO2/KCNQ1OT1/DHX9/PUM1/EIF4G1/FMR1 8 GO:0031498 chromatin disassembly 5/896 20/18722 0.00210924920196033 0.0230830572577427 SUPT16H/SMARCC1/SET/SMARCA4/HMGA1 5 GO:0032986 protein-DNA complex disassembly 5/896 20/18722 0.00210924920196033 0.0230830572577427 SUPT16H/SMARCC1/SET/SMARCA4/HMGA1 5 GO:0046931 pore complex assembly 5/896 20/18722 0.00210924920196033 0.0230830572577427 NDC1/NUP107/TMEM170A/ANO6/RTN4 5 GO:0048025 negative regulation of mRNA splicing, via spliceosome 5/896 20/18722 0.00210924920196033 0.0230830572577427 SRSF10/RBMX/SRSF4/SRSF7/RNPS1 5 GO:0072009 nephron epithelium development 13/896 109/18722 0.00211296523285161 0.0230830572577427 LAMA5/PKD2/DLG1/PBX1/YAP1/LGR4/IRX2/AHI1/ASXL1/IQGAP1/TACSTD2/MAGED1/CD24 13 GO:1901880 negative regulation of protein depolymerization 10/896 72/18722 0.0021745789831113 0.0236279976572566 TPX2/CKAP2/SPTBN1/EPS8/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP 10 GO:0010458 exit from mitosis 6/896 29/18722 0.00217769563661351 0.0236279976572566 UBE2C/UBE2S/ANLN/CDCA5/EPS8/KNTC1 6 GO:0050686 negative regulation of mRNA processing 6/896 29/18722 0.00217769563661351 0.0236279976572566 BARD1/SRSF10/RBMX/SRSF4/SRSF7/RNPS1 6 GO:0043624 cellular protein complex disassembly 15/896 136/18722 0.00219739479957056 0.0237785442273446 STMN1/TPX2/CKAP2/SPTBN1/KIF2C/CKAP5/EPS8/KIF18A/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP/HSPA8 15 GO:0008406 gonad development 21/896 221/18722 0.00220153258242277 0.0237785442273446 HMGB2/ASPM/LRP2/RRM1/NASP/BRCA2/ADGRG1/NR2F2/CTSV/ADAMTS1/MSH2/KIF18A/NUP107/CCND1/SF1/HSPA5/PRDX4/PLEKHA1/ATRX/ZFX/RHOBTB3 21 GO:0061008 hepaticobiliary system development 16/896 150/18722 0.00225063070314128 0.0242539751169221 TYMS/PCNA/MET/EGFR/AURKA/EZH2/PKD2/CCND1/NF1/COBL/HNRNPD/SEC63/TGFBR3/PRKCSH/LSR/SRSF5 16 GO:0032506 cytokinetic process 7/896 39/18722 0.00225673175026907 0.0242649490445598 ANLN/KIF20B/ECT2/AURKB/CEP55/RACGAP1/KIF20A 7 GO:0010720 positive regulation of cell development 26/896 298/18722 0.00239009712186659 0.0256411767635755 ASPM/LRP2/PRKDC/EGFR/AURKA/MME/DAG1/NRP1/XRCC2/NAP1L1/DICER1/PLXNB1/GOLGA4/SPINT1/P4HB/MACF1/CALR/HDAC2/LRP1/ETV5/UFL1/SERPINF1/TRIOBP/XRCC5/TGM2/RHEB 26 GO:0045814 negative regulation of gene expression, epigenetic 8/896 50/18722 0.00239731698156123 0.0256609669730343 HELLS/EZH2/TPR/DNMT1/DNMT3A/TRIM28/SMARCA5/CREBZF 8 GO:0044409 entry into host 16/896 151/18722 0.00240859992937041 0.025695709560826 CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/NRP1/CD46/ITGB5/P4HB/SLC1A5/SIVA1/LY6E/FUCA2/CTSL/BSG 16 GO:0086003 cardiac muscle cell contraction 10/896 73/18722 0.00241406110569963 0.025695709560826 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/DLG1/ATP2A2/DSC2/AKAP9 10 GO:0046661 male sex differentiation 17/896 165/18722 0.00241671001106219 0.025695709560826 HMGB2/ASPM/LRP2/RRM1/NASP/ADGRG1/DHCR24/CTSV/MSH2/KIF18A/CCND1/LGR4/SF1/PRDX4/PLEKHA1/ATRX/RHOBTB3 17 GO:0031056 regulation of histone modification 16/896 152/18722 0.00257568114342497 0.0273251150638018 CCNB1/BRCA1/RIF1/CHEK1/NCAPG2/MTF2/DNMT1/CTCF/BRD7/SET/ZNF451/PAXBP1/FMR1/BRD4/ATRX/EID1 16 GO:0045070 positive regulation of viral genome replication 6/896 30/18722 0.00261351826542676 0.0274657919124738 TOP2A/HACD3/SRPK1/PKN2/LARP1/DDB1 6 GO:0046825 regulation of protein export from nucleus 6/896 30/18722 0.00261351826542676 0.0274657919124738 BARD1/XPO1/PTPN14/TPR/CTDSPL2/ANP32B 6 GO:0060674 placenta blood vessel development 6/896 30/18722 0.00261351826542676 0.0274657919124738 NR2F2/ITGB8/PKD2/FZD5/SPINT1/RBPJ 6 GO:2000637 positive regulation of gene silencing by miRNA 6/896 30/18722 0.00261351826542676 0.0274657919124738 EGFR/AGO2/DHX9/PUM1/EIF4G1/FMR1 6 GO:0030866 cortical actin cytoskeleton organization 7/896 40/18722 0.00262438934990297 0.0274657919124738 ANLN/ECT2/RACGAP1/DLG1/ROCK2/CALR/EPB41L3 7 GO:0042769 DNA damage response, detection of DNA damage 4/896 13/18722 0.00263296877370168 0.0274657919124738 PARP1/USP1/SOX4/MRPS26 4 GO:0060670 branching involved in labyrinthine layer morphogenesis 4/896 13/18722 0.00263296877370168 0.0274657919124738 FZD5/SPINT1/SPINT2/ST14 4 GO:0018210 peptidyl-threonine modification 14/896 125/18722 0.00263496704983514 0.0274657919124738 CDK1/PRKDC/GALNT11/APP/BMP7/TTK/PLK1/CHEK1/VRK1/PARD3/CIT/CALM2/ROCK2/EIF4G1 14 GO:0060445 branching involved in salivary gland morphogenesis 5/896 21/18722 0.00266055528036355 0.0276119367575121 DAG1/BMP7/NRP1/LAMA5/TGM2 5 GO:0150105 protein localization to cell-cell junction 5/896 21/18722 0.00266055528036355 0.0276119367575121 DSP/DLG5/VCL/MPP7/LSR 5 GO:0050769 positive regulation of neurogenesis 21/896 225/18722 0.00273182162778265 0.0282900573775149 ASPM/LRP2/EGFR/MME/DAG1/NRP1/XRCC2/NAP1L1/DICER1/PLXNB1/GOLGA4/SPINT1/MACF1/HDAC2/LRP1/ETV5/UFL1/SERPINF1/XRCC5/TGM2/RHEB 21 GO:0031032 actomyosin structure organization 19/896 196/18722 0.00279227339927152 0.0288534917924723 STMN1/MYH10/ANLN/MET/ECT2/ITGB1/NRP1/RACGAP1/FRMD6/CIT/ROCK2/PPP1R9A/ITGB5/PDLIM1/TRPM7/EPB41L3/TACSTD2/CSRP2/PPFIA1 19 GO:0051056 regulation of small GTPase mediated signal transduction 26/896 302/18722 0.00286642226871561 0.0295557233495644 STMN1/MET/ECT2/ADGRG1/ITGAV/ARHGAP11A/ITGB1/NRP1/RACGAP1/ARHGAP21/ARHGAP11B/AMOT/KANK1/KIF14/EPS8/SYDE2/FOXM1/ARFGEF3/ARHGAP5/RDX/NET1/ARHGAP23/ARHGAP10/CD2AP/RASA1/TGM2 26 GO:1902373 negative regulation of mRNA catabolic process 9/896 63/18722 0.00293367324327977 0.0301190452976723 FUS/HNRNPD/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/FMR1/THRAP3 9 GO:2000756 regulation of peptidyl-lysine acetylation 9/896 63/18722 0.00293367324327977 0.0301190452976723 BRCA1/CHEK1/SOX4/CTCF/BRD7/SET/ZNF451/HDAC2/EID1 9 GO:0061333 renal tubule morphogenesis 10/896 75/18722 0.00295637634979527 0.0302221428135388 LGR5/LAMA5/PKD2/DLG1/PBX1/LGR4/IRX2/AHI1/TACSTD2/MAGED1 10 GO:1902369 negative regulation of RNA catabolic process 10/896 75/18722 0.00295637634979527 0.0302221428135388 FUS/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/FMR1/THRAP3 10 GO:0051962 positive regulation of nervous system development 24/896 272/18722 0.002979252996799 0.0303909269374325 ASPM/LRP2/EGFR/MME/DAG1/NRP1/TPBG/CLSTN1/XRCC2/NAP1L1/DICER1/DLG5/PLXNB1/GOLGA4/SPINT1/MACF1/HDAC2/LRP1/ETV5/UFL1/SERPINF1/XRCC5/TGM2/RHEB 24 GO:0045137 development of primary sexual characteristics 21/896 227/18722 0.00303490227803553 0.0308268584581736 HMGB2/ASPM/LRP2/RRM1/NASP/BRCA2/ADGRG1/NR2F2/CTSV/ADAMTS1/MSH2/KIF18A/NUP107/CCND1/SF1/HSPA5/PRDX4/PLEKHA1/ATRX/ZFX/RHOBTB3 21 GO:0071826 ribonucleoprotein complex subunit organization 21/896 227/18722 0.00303490227803553 0.0308268584581736 PRKDC/HSP90AA1/PSIP1/SRPK1/AGO2/SRSF10/DICER1/EIF3A/SF1/LUC7L3/DHX9/SNRPD1/KIF5B/LSM4/PRPF8/SCAF11/LSM2/XRCC5/SNRPG/SRSF5/HSP90AB1 21 GO:0030048 actin filament-based movement 14/896 127/18722 0.00305214704081037 0.0309361995176831 SYNE2/MYH10/DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/EMP2/DLG1/ATP2A2/DSC2/MYO1C/AKAP9 14 GO:0002218 activation of innate immune response 8/896 52/18722 0.00308967287111478 0.0310080963977002 HMGB1/PRKDC/HSP90AA1/SFPQ/PSPC1/NONO/XRCC5/XRCC6 8 GO:0060147 regulation of posttranscriptional gene silencing 8/896 52/18722 0.00308967287111478 0.0310080963977002 EGFR/LIN28B/AGO2/KCNQ1OT1/DHX9/PUM1/EIF4G1/FMR1 8 GO:0006301 postreplication repair 6/896 31/18722 0.00311160393447021 0.0310080963977002 PCNA/BRCA1/DTL/MSH2/REV1/USP10 6 GO:0060148 positive regulation of posttranscriptional gene silencing 6/896 31/18722 0.00311160393447021 0.0310080963977002 EGFR/AGO2/DHX9/PUM1/EIF4G1/FMR1 6 GO:0071480 cellular response to gamma radiation 6/896 31/18722 0.00311160393447021 0.0310080963977002 RAD51/YAP1/HSPA5/TMEM109/XRCC5/XRCC6 6 GO:0001701 in utero embryonic development 30/896 367/18722 0.00311832919920365 0.0310080963977002 CCNB1/NASP/BRCA2/CCNB2/BMP7/ITGB1/NR2F2/RRM2/AMOT/CHEK1/ASF1B/MSH2/XRCC2/PKD2/NCAPG2/NEK2/FUT8/FZD5/YAP1/SETD2/SPINT1/BPTF/SPINT2/TRIM28/CNOT1/ST14/SLC39A1/LY6E/RBPJ/RTN4 30 GO:0008584 male gonad development 15/896 141/18722 0.00312156277809521 0.0310080963977002 HMGB2/ASPM/LRP2/RRM1/NASP/ADGRG1/CTSV/MSH2/KIF18A/CCND1/SF1/PRDX4/PLEKHA1/ATRX/RHOBTB3 15 GO:0034249 negative regulation of cellular amide metabolic process 24/896 273/18722 0.00312293909859698 0.0310080963977002 TYMS/HNRNPR/DHFR/EXOSC8/TPR/ROCK2/IGF2BP3/AGO2/ILF3/HNRNPD/TNRC6A/DCP2/CNOT1/CALR/LARP1/SYNCRIP/PUM1/KHSRP/EIF4G1/FMR1/PURA/ORMDL1/RTN4/NCL 24 GO:0007179 transforming growth factor beta receptor signaling pathway 19/896 198/18722 0.00312728123240775 0.0310080963977002 FBN2/FBN1/PARP1/ITGB8/LTBP1/FUT8/GCNT2/FERMT1/ITGB5/GLG1/PEG10/TRIM33/ID1/ZNF451/HSPA5/TGFBR3/NREP/USP9X/HSP90AB1 19 GO:0031110 regulation of microtubule polymerization or depolymerization 11/896 88/18722 0.00313068757094501 0.0310080963977002 STMN1/TPX2/CKAP2/MET/CKAP5/CDK5RAP2/SKA3/SKA2/CAMSAP2/CLIP1/AKAP9 11 GO:0050779 RNA destabilization 11/896 88/18722 0.00313068757094501 0.0310080963977002 HNRNPR/EXOSC8/LIN28B/ROCK2/AGO2/HNRNPD/TNRC6A/DCP2/CNOT1/PUM1/KHSRP 11 GO:0021987 cerebral cortex development 13/896 114/18722 0.00314865188762972 0.0311214577878764 ASPM/LAMB1/ADGRG1/ARHGAP11B/TACC3/KIF14/CNTNAP2/NF1/SLC38A2/LRP1/SLC2A1/TRA2B/RTN4 13 GO:0150115 cell-substrate junction organization 12/896 101/18722 0.00318374572080047 0.0314033100642591 ITGA6/LAMC1/NRP1/ITGB4/DST/ACTN1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 12 GO:0006305 DNA alkylation 10/896 76/18722 0.00326174924832889 0.0319745193255074 HELLS/EZH2/PARP1/BRCA1/MIS18A/DNMT1/CTCF/DNMT3A/TRIM28/ATRX 10 GO:0006306 DNA methylation 10/896 76/18722 0.00326174924832889 0.0319745193255074 HELLS/EZH2/PARP1/BRCA1/MIS18A/DNMT1/CTCF/DNMT3A/TRIM28/ATRX 10 GO:0072028 nephron morphogenesis 10/896 76/18722 0.00326174924832889 0.0319745193255074 BMP7/LAMA5/PKD2/DLG1/PBX1/LGR4/IRX2/AHI1/TACSTD2/MAGED1 10 GO:0048026 positive regulation of mRNA splicing, via spliceosome 5/896 22/18722 0.00330913332552498 0.0323063445727122 RBMX/THRAP3/TRA2B/HSPA8/NCL 5 GO:0060713 labyrinthine layer morphogenesis 5/896 22/18722 0.00330913332552498 0.0323063445727122 BMP7/FZD5/SPINT1/SPINT2/ST14 5 GO:0046546 development of primary male sexual characteristics 15/896 142/18722 0.00334017231488729 0.0325428216964733 HMGB2/ASPM/LRP2/RRM1/NASP/ADGRG1/CTSV/MSH2/KIF18A/CCND1/SF1/PRDX4/PLEKHA1/ATRX/RHOBTB3 15 GO:0044403 biological process involved in symbiotic interaction 25/896 290/18722 0.00335681021384821 0.0326383135660109 CDK1/NUCKS1/EGFR/DAG1/ITGAV/DPP4/ITGB1/NRP1/CD46/ITGB5/SMARCA4/P4HB/SLC1A5/TRIM28/SIVA1/HSPD1/LY6E/FMR1/ANO6/FUCA2/HSPA8/DDB1/CTSL/BSG/HSP90AB1 25 GO:0061564 axon development 36/896 467/18722 0.00343215102202938 0.0333030263804233 STMN1/NRP2/APP/DAG1/BMP7/HSP90AA1/DHFR/ITGB1/NRP1/SEMA6D/LAMA5/PARD3/ANK3/NFIB/SEMA6A/MTR/NRCAM/COBL/PTPRM/PALLD/VCL/PLXNB1/RYK/GOLGA4/CAMSAP2/MACF1/NREP/AFG3L2/PARD6B/STK24/KIF5B/LRP1/USP9X/RTN4/BSG/HSP90AB1 36 GO:0060966 regulation of gene silencing by RNA 8/896 53/18722 0.0034895008057418 0.0337908252466762 EGFR/LIN28B/AGO2/KCNQ1OT1/DHX9/PUM1/EIF4G1/FMR1 8 GO:0045860 positive regulation of protein kinase activity 31/896 386/18722 0.003500541553049 0.0338291201908015 CCNB1/TPX2/HMGB1/CKS2/CENPE/EGFR/CKS1B/ECT2/DAG1/EZH2/CLSPN/HSP90AA1/DBF4/CDC6/KIF14/PKD2/EMP2/DLG1/CCND1/FZD5/CALM2/VLDLR/PPP1R9A/PRLR/IQGAP1/MAGED1/CD24/XRCC5/XRCC6/ERP29/HSP90AB1 31 GO:0017148 negative regulation of translation 22/896 245/18722 0.00352419518921161 0.0339889047137297 TYMS/HNRNPR/DHFR/EXOSC8/TPR/ROCK2/IGF2BP3/AGO2/ILF3/HNRNPD/TNRC6A/DCP2/CNOT1/CALR/LARP1/SYNCRIP/PUM1/KHSRP/EIF4G1/FMR1/PURA/NCL 22 GO:1904814 regulation of protein localization to chromosome, telomeric region 4/896 14/18722 0.00354773181945803 0.0340782126883152 CCT5/CCT6A/CCT2/CCT4 4 GO:1990173 protein localization to nucleoplasm 4/896 14/18722 0.00354773181945803 0.0340782126883152 CCT5/CCT6A/CCT2/CCT4 4 GO:0007548 sex differentiation 24/896 276/18722 0.0035895454756621 0.0343621121813414 HMGB2/ASPM/LRP2/RRM1/NASP/BRCA2/ADGRG1/NR2F2/DHCR24/CTSV/ADAMTS1/MSH2/KIF18A/NUP107/CCND1/PBX1/LGR4/SF1/HSPA5/PRDX4/PLEKHA1/ATRX/ZFX/RHOBTB3 24 GO:1901983 regulation of protein acetylation 10/896 77/18722 0.00359168286101578 0.0343621121813414 BRCA1/CHEK1/CEP295/SOX4/CTCF/BRD7/SET/ZNF451/HDAC2/EID1 10 GO:1902115 regulation of organelle assembly 18/896 186/18722 0.00362192526788141 0.0345821424577317 BRCA1/PLK1/GPSM2/CEP295/CENPJ/CDK5RAP2/KIF15/CCP110/CEP135/TPR/YAP1/RDX/G3BP1/HNRNPU/DYNC1H1/CNOT1/ATMIN/ASAP1 18 GO:0006487 protein N-linked glycosylation 9/896 65/18722 0.00364026120994104 0.034640455355319 RPN2/FUT8/ALG10B/STT3B/TUSC3/GFPT1/RPN1/TMEM165/DDOST 9 GO:0048545 response to steroid hormone 28/896 339/18722 0.00364254473991834 0.034640455355319 HMGB2/TYMS/HMGB1/PCNA/EGFR/ATP2B1/AGL/BMP7/PARP1/BRCA1/CTSV/ATP1A1/CCND1/YWHAH/YAP1/SKP2/NEDD4/SMARCA4/HNRNPU/CNOT1/CALR/HSPD1/RBBP7/GLB1/UFL1/SERPINF1/DDX17/CLDN4 28 GO:0018107 peptidyl-threonine phosphorylation 13/896 116/18722 0.00366439557966784 0.0346935565011104 CDK1/PRKDC/APP/BMP7/TTK/PLK1/CHEK1/VRK1/PARD3/CIT/CALM2/ROCK2/EIF4G1 13 GO:0007435 salivary gland morphogenesis 6/896 32/18722 0.00367719723283658 0.0346935565011104 DAG1/BMP7/NRP1/LAMA5/NFIB/TGM2 6 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 6/896 32/18722 0.00367719723283658 0.0346935565011104 EZH2/SUPT16H/TCERG1/RNF168/HNRNPU/BRD4 6 GO:0050685 positive regulation of mRNA processing 6/896 32/18722 0.00367719723283658 0.0346935565011104 CCNB1/RBMX/THRAP3/TRA2B/HSPA8/NCL 6 GO:1990138 neuron projection extension 17/896 172/18722 0.00372417131932038 0.03506744354721 AURKA/NRP2/HSP90AA1/ITGB1/NRP1/SEMA6D/SEMA6A/NRCAM/VCL/RYK/GOLGA4/IQGAP1/MACF1/LRP1/USP9X/RTN4/HSP90AB1 17 GO:0034644 cellular response to UV 11/896 90/18722 0.00373371715236913 0.0350881214279729 PCNA/MME/PBK/PARP1/AURKB/CHEK1/POLD3/NEDD4/FMR1/USP47/DDB1 11 GO:0014013 regulation of gliogenesis 12/896 103/18722 0.00374501467792159 0.0351251474899757 LRP2/EGFR/DAG1/EZH2/NF1/DICER1/SPINT1/HDAC2/ETV5/UFL1/IDH2/RHEB 12 GO:0046718 viral entry into host cell 15/896 144/18722 0.00381514160109498 0.0357127176541714 CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/NRP1/CD46/ITGB5/P4HB/SLC1A5/SIVA1/LY6E/CTSL/BSG 15 GO:0032271 regulation of protein polymerization 21/896 232/18722 0.00391811724623875 0.0366048761908881 STMN1/MET/IQGAP2/HSP90AA1/SPTBN1/KANK1/KANK4/CKAP5/EPS8/CDK5RAP2/SVIL/DLG1/PPP1R9A/RDX/MYO1C/CAMSAP2/CLIP1/ADD3/AKAP9/TRIOBP/RASA1 21 GO:0086002 cardiac muscle cell action potential involved in contraction 8/896 54/18722 0.00392826006812859 0.0366279561821209 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/DLG1/DSC2 8 GO:0051099 positive regulation of binding 17/896 173/18722 0.00395140100944057 0.0367719072496477 HMGB2/STMN1/HMGB1/MET/APP/GMNN/PARP1/NRP1/CDT1/CALM2/DHX9/TRIM28/RAN/EIF4G1/FMR1/LRP1/HSP90AB1 17 GO:0045840 positive regulation of mitotic nuclear division 7/896 43/18722 0.00400665096873402 0.0372135247562961 NUSAP1/AURKA/DLGAP5/CDT1/PHIP/LRP5/ANAPC5 7 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 9/896 66/18722 0.00404025130389074 0.0373078524657145 HMGB2/HMGB1/PRKDC/RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 9 GO:0014015 positive regulation of gliogenesis 9/896 66/18722 0.00404025130389074 0.0373078524657145 LRP2/EGFR/DAG1/DICER1/SPINT1/HDAC2/ETV5/UFL1/RHEB 9 GO:0016444 somatic cell DNA recombination 9/896 66/18722 0.00404025130389074 0.0373078524657145 HMGB2/HMGB1/PRKDC/RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 9 GO:0042026 protein refolding 5/896 23/18722 0.00406406969194851 0.0374211519582098 HSP90AA1/HSPA5/HSPD1/HSPA9/HSPA8 5 GO:0072080 nephron tubule development 11/896 91/18722 0.00406819812867844 0.0374211519582098 LAMA5/PKD2/DLG1/PBX1/YAP1/LGR4/IRX2/AHI1/TACSTD2/MAGED1/CD24 11 GO:0051701 biological process involved in interaction with host 19/896 203/18722 0.00411393602540426 0.0377690972793845 CDK1/EGFR/DAG1/ITGAV/DPP4/ITGB1/NRP1/CD46/ITGB5/P4HB/SLC1A5/TRIM28/SIVA1/LY6E/ANO6/FUCA2/DDB1/CTSL/BSG 19 GO:0042176 regulation of protein catabolic process 31/896 391/18722 0.00422858005785936 0.038747104023456 LRP2/CDH1/EGFR/AURKA/MAD2L1/PBK/CDC20/HSP90AA1/BARD1/DTL/XPO1/GJA1/PLK1/PSMD1/NUDT15/SMARCC1/TMTC3/RDX/NEDD4/CDK2/FBXO22/RNF217/HUWE1/FMR1/LRP1/USP14/UFL1/PSMD14/DDB1/RAD23B/HSP90AB1 31 GO:1902275 regulation of chromatin organization 6/896 33/18722 0.00431560942146882 0.0394688110691421 MKI67/SSRP1/TPR/DNMT1/HNRNPU/TRIM28 6 GO:0060560 developmental growth involved in morphogenesis 21/896 234/18722 0.00432681321928124 0.0394956143572632 AURKA/NRP2/APP/HSP90AA1/ITGB1/NRP1/SEMA6D/SEMA6A/NRCAM/YAP1/COBL/VCL/RYK/GOLGA4/IQGAP1/MACF1/TRIM28/LRP1/USP9X/RTN4/HSP90AB1 21 GO:0007015 actin filament organization 34/896 441/18722 0.00437116778361503 0.0398243416011033 STMN1/DIAPH3/MET/HSP90B1/IQGAP2/NRP1/SPTBN1/KANK1/PAWR/FAT1/KANK4/EPS8/GAS2L3/SVIL/EMP2/DLG1/ACTN1/ROCK2/COBL/PPP1R9A/RDX/ITGB5/MYO1C/ID1/PDLIM1/ADD3/CALD1/TACSTD2/CD2AP/LIMA1/PPFIA1/TRIOBP/RHOBTB3/RASA1 34 GO:0098900 regulation of action potential 8/896 55/18722 0.00440838710655001 0.0400869334222281 DSP/DSG2/GJA5/DLG1/ATP2A2/DSC2/AKAP9/FMR1 8 GO:0016445 somatic diversification of immunoglobulins 9/896 67/18722 0.0044737717971035 0.0406041569569812 PRKDC/RIF1/MSH6/POLQ/MSH2/RNF168/UNG/HSPD1/CTNNBL1 9 GO:0071560 cellular response to transforming growth factor beta stimulus 22/896 250/18722 0.00448404274712142 0.0406201519445117 FBN2/FBN1/PARP1/COL4A2/ITGB8/LTBP1/FUT8/GCNT2/FERMT1/ITGB5/GLG1/PEG10/TRIM33/ID1/ZNF451/HSPA5/TGFBR3/NREP/YES1/HDAC2/USP9X/HSP90AB1 22 GO:0009262 deoxyribonucleotide metabolic process 7/896 44/18722 0.00457191353971438 0.0412221974034105 TYMS/RRM1/DUT/DTYMK/RRM2/NUDT15/UNG 7 GO:0022618 ribonucleoprotein complex assembly 20/896 220/18722 0.00457640649849341 0.0412221974034105 PRKDC/HSP90AA1/PSIP1/SRPK1/AGO2/SRSF10/DICER1/EIF3A/SF1/LUC7L3/DHX9/SNRPD1/LSM4/PRPF8/SCAF11/LSM2/XRCC5/SNRPG/SRSF5/HSP90AB1 20 GO:0044706 multi-multicellular organism process 20/896 220/18722 0.00457640649849341 0.0412221974034105 NR2F2/SLC38A1/ITGB4/GJA1/CTSV/EMP2/SLC6A4/PPAT/AGO2/FBLN1/PRLR/SLC38A2/STS/TRIM28/CALR/HEXB/ASH1L/SLC2A1/CLDN4/BSG 20 GO:0016446 somatic hypermutation of immunoglobulin genes 4/896 15/18722 0.00465646438853267 0.0415513289548691 MSH6/POLQ/MSH2/UNG 4 GO:0032239 regulation of nucleobase-containing compound transport 4/896 15/18722 0.00465646438853267 0.0415513289548691 TPR/DHX9/SETD2/KHDRBS1 4 GO:0048569 post-embryonic animal organ development 4/896 15/18722 0.00465646438853267 0.0415513289548691 EFEMP1/FBN1/FZD5/HMGN1 4 GO:0086069 bundle of His cell to Purkinje myocyte communication 4/896 15/18722 0.00465646438853267 0.0415513289548691 DSP/DSG2/GJA5/DSC2 4 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 4/896 15/18722 0.00465646438853267 0.0415513289548691 CCT5/CCT6A/CCT2/CCT4 4 GO:0009791 post-embryonic development 10/896 80/18722 0.004742535710033 0.0422404206710775 EFEMP1/FBN1/FZD5/AGO2/CCDC47/PLEKHA1/ASH1L/ATRX/ZFX/HMGN1 10 GO:0031647 regulation of protein stability 25/896 298/18722 0.00476458435020981 0.0423577759551241 PRKDC/AURKA/HSP90AA1/PLK1/MCM8/SOX4/TBL1X/CTNND1/TRIM24/USP27X/CALR/HSPD1/ATP1B3/USP9X/USP47/TRIM44/CCT5/HSPA8/CCT6A/CCT2/CMTM6/CCT4/DDOST/RTN4/HSP90AB1 25 GO:0090398 cellular senescence 11/896 93/18722 0.0048086212438021 0.042669810070467 PRKDC/FBXO5/PAWR/RBL1/SMC6/CDKN2A/CDK6/CDK2/SMC5/CALR/HMGA1 11 GO:0016055 Wnt signaling pathway 34/896 444/18722 0.00484790277702453 0.0429385674536458 ASPM/EGFR/LGR5/APP/WLS/RNF43/TPBG/KANK1/LRP5/PKD2/SOX4/ZNRF3/CCND1/FZD5/FZD6/FERMT1/YAP1/LGR4/HMGXB4/BRD7/G3BP1/AMOTL1/RYK/SMARCA4/TBL1X/CTNND1/MACF1/CCNE1/LRP1/USP47/RBPJ/CD24/TLE4/DDB1 34 GO:0048255 mRNA stabilization 8/896 56/18722 0.00493236192830008 0.0435936415134665 FUS/HNRNPD/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/THRAP3 8 GO:0032922 circadian regulation of gene expression 9/896 68/18722 0.00494266691975257 0.0435936415134665 ID4/ZFHX3/LGR4/HNRNPU/ID1/GFPT1/HUWE1/HDAC2/MAGED1 9 GO:0030900 forebrain development 30/896 379/18722 0.00495121088847783 0.0435936415134665 ASPM/LRP2/RRM1/CDH1/LAMB1/NRP2/APP/EZH2/ADGRG1/NRP1/NR2F2/ARHGAP11B/PGAP1/TACC3/KIF14/CNTNAP2/NFIB/NF1/PCM1/CDK6/SLC38A2/SETD2/RYK/KIF5B/LRP1/SLC2A1/ATRX/RBPJ/TRA2B/RTN4 30 GO:0001508 action potential 14/896 134/18722 0.00495838863464858 0.0435936415134665 DSP/DSG2/GJA5/GJA1/ATP1A1/ANK3/NUP155/DLG1/YWHAH/ATP2A2/DSC2/USP53/AKAP9/FMR1 14 GO:0198738 cell-cell signaling by wnt 34/896 446/18722 0.00518954875692181 0.0454253597959131 ASPM/EGFR/LGR5/APP/WLS/RNF43/TPBG/KANK1/LRP5/PKD2/SOX4/ZNRF3/CCND1/FZD5/FZD6/FERMT1/YAP1/LGR4/HMGXB4/BRD7/G3BP1/AMOTL1/RYK/SMARCA4/TBL1X/CTNND1/MACF1/CCNE1/LRP1/USP47/RBPJ/CD24/TLE4/DDB1 34 GO:0010824 regulation of centrosome duplication 7/896 45/18722 0.00519527575378479 0.0454253597959131 BRCA1/XPO1/CEP295/CENPJ/CDK5RAP2/CCNF/ROCK2 7 GO:0030835 negative regulation of actin filament depolymerization 7/896 45/18722 0.00519527575378479 0.0454253597959131 SPTBN1/EPS8/SVIL/RDX/ADD3/LIMA1/TRIOBP 7 GO:1902414 protein localization to cell junction 11/896 94/18722 0.00521684293069773 0.0455305450660895 DSP/DAG1/MARVELD3/CLSTN1/DLG1/DLG5/VCL/ZDHHC12/MPP7/KIF5B/LSR 11 GO:0007565 female pregnancy 18/896 193/18722 0.00533161856713224 0.0464473486122068 NR2F2/SLC38A1/ITGB4/GJA1/CTSV/EMP2/PPAT/AGO2/FBLN1/PRLR/SLC38A2/STS/TRIM28/CALR/ASH1L/SLC2A1/CLDN4/BSG 18 GO:0030198 extracellular matrix organization 25/896 301/18722 0.005406219997034 0.0470114649651008 COL14A1/LAMB1/ADAMTSL4/APP/DAG1/LAMC1/DPP4/ITGB1/CTSV/ADAMTS6/COL4A2/ADAMTS19/ADAMTS1/NF1/FERMT1/COL5A2/FBLN1/ST7/CCDC80/VWA1/SPINT1/SPINT2/PRDX4/LRP1/SERPINH1 25 GO:0006368 transcription elongation from RNA polymerase II promoter 9/896 69/18722 0.00544881256840632 0.0472956930937669 EZH2/SUPT16H/CDCA4/CHEK1/TCERG1/RNF168/SETD2/HNRNPU/BRD4 9 GO:0034446 substrate adhesion-dependent cell spreading 12/896 108/18722 0.00550106268970882 0.0475903987330927 LAMB1/LAMC1/ITGAV/NRP1/LAMA5/KANK1/KIF14/FBLN1/P4HB/CALR/TACSTD2/TRIOBP 12 GO:0051785 positive regulation of nuclear division 8/896 57/18722 0.00550270215765964 0.0475903987330927 NUSAP1/AURKA/DLGAP5/RAD51AP1/CDT1/PHIP/LRP5/ANAPC5 8 GO:0007018 microtubule-based movement 30/896 382/18722 0.00552987761403431 0.0476527720747288 KIF23/KIF20B/CENPE/DLGAP5/APP/KPNB1/KIF11/KIF4A/ARHGAP21/DST/KIF22/KIF2C/KIF14/KIF18A/KIFC1/KIF20A/KIF15/VPS13A/PCM1/SFPQ/LRPPRC/HNRNPU/DYNC1H1/DYNC1LI2/KIF5B/PURA/ASH1L/HSPB11/KTN1/HSPA8 30 GO:1902903 regulation of supramolecular fiber organization 30/896 382/18722 0.00552987761403431 0.0476527720747288 STMN1/TPX2/CKAP2/MET/APP/IQGAP2/NRP1/SPTBN1/KANK1/KANK4/CKAP5/EPS8/CDK5RAP2/SVIL/DLG1/ROCK2/PPP1R9A/RDX/MYO1C/CAMSAP2/ID1/CLIP1/ADD3/AKAP9/TACSTD2/LIMA1/PPFIA1/TRIOBP/HSPA8/RASA1 30 GO:0043062 extracellular structure organization 25/896 302/18722 0.00563544361872336 0.0484749690734871 COL14A1/LAMB1/ADAMTSL4/APP/DAG1/LAMC1/DPP4/ITGB1/CTSV/ADAMTS6/COL4A2/ADAMTS19/ADAMTS1/NF1/FERMT1/COL5A2/FBLN1/ST7/CCDC80/VWA1/SPINT1/SPINT2/PRDX4/LRP1/SERPINH1 25 GO:0072073 kidney epithelium development 14/896 136/18722 0.00565124405186107 0.0484957172014828 BMP7/LAMA5/PKD2/DLG1/PBX1/YAP1/LGR4/IRX2/AHI1/ASXL1/IQGAP1/TACSTD2/MAGED1/CD24 14 GO:0043242 negative regulation of protein-containing complex disassembly 10/896 82/18722 0.00565817228345747 0.0484957172014828 TPX2/CKAP2/SPTBN1/EPS8/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP 10 GO:0007020 microtubule nucleation 6/896 35/18722 0.00583231406478197 0.0498094228001236 TPX2/CKAP5/CENPJ/TUBG1/MZT1/AKAP9 6 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 6/896 35/18722 0.00583231406478197 0.0498094228001236 PARP1/BRCA1/YAP1/SKP2/CNOT1/UFL1 6 GO:0007019 microtubule depolymerization 7/896 46/18722 0.00588030384657791 0.0498761256987861 STMN1/TPX2/CKAP2/KIF2C/CKAP5/KIF18A/CAMSAP2 7 GO:0070828 heterochromatin organization 7/896 46/18722 0.00588030384657791 0.0498761256987861 HELLS/HP1BP3/TPR/DNMT1/DNMT3A/TRIM28/SMARCA5 7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 7/896 46/18722 0.00588030384657791 0.0498761256987861 EGFR/CDC6/ADAMTS1/CCND1/TFDP1/RDX/EIF4G1 7 GO:0010721 negative regulation of cell development 17/896 180/18722 0.00588191427909857 0.0498761256987861 FBN1/BMP7/NRP1/SEMA6D/KANK1/PRTG/SEMA6A/YWHAH/NF1/DICER1/PCM1/FBLN1/RYK/ID1/TACSTD2/IDH2/RTN4 17 GO:0030705 cytoskeleton-dependent intracellular transport 18/896 195/18722 0.00592613101956907 0.0498790851509881 TUBB/TUBA1B/SYNE2/TUBA1C/APP/KIF4A/ARHGAP21/DST/PCM1/SFPQ/LRPPRC/MYO1C/HNRNPU/DYNC1H1/KIF5B/PURA/HSPB11/HSPA8 18 GO:0033119 negative regulation of RNA splicing 5/896 25/18722 0.00592901677725025 0.0498790851509881 SRSF10/RBMX/SRSF4/SRSF7/RNPS1 5 GO:0070199 establishment of protein localization to chromosome 5/896 25/18722 0.00592901677725025 0.0498790851509881 BRCA2/CCT5/CCT6A/CCT2/CCT4 5 GO:0002566 somatic diversification of immune receptors via somatic mutation 4/896 16/18722 0.00597629591670825 0.0498790851509881 MSH6/POLQ/MSH2/UNG 4 GO:0010649 regulation of cell communication by electrical coupling 4/896 16/18722 0.00597629591670825 0.0498790851509881 GJA5/GJA1/ANK3/CALM2 4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 4/896 16/18722 0.00597629591670825 0.0498790851509881 EZH2/TCERG1/RNF168/HNRNPU 4 GO:0048385 regulation of retinoic acid receptor signaling pathway 4/896 16/18722 0.00597629591670825 0.0498790851509881 EZH2/ASXL1/CNOT1/CALR 4 GO:0071732 cellular response to nitric oxide 4/896 16/18722 0.00597629591670825 0.0498790851509881 CCNA2/MTR/HNRNPD/CDK2 4 GO:0072148 epithelial cell fate commitment 4/896 16/18722 0.00597629591670825 0.0498790851509881 NRP1/NR2F2/ESRP1/RBPJ 4 GO:0034599 cellular response to oxidative stress 24/896 288/18722 0.00608277973305914 0.050564398272685 CDK1/PCNA/MET/EGFR/ECT2/EZH2/BMP7/PARP1/DHFR/GPX8/PAWR/MELK/PKD2/FUT8/ATP2A2/SFPQ/NET1/P4HB/OXR1/PLEKHA1/STK24/HDAC2/ETV5/NONO 24 GO:0045229 external encapsulating structure organization 25/896 304/18722 0.00611814362462118 0.050564398272685 COL14A1/LAMB1/ADAMTSL4/APP/DAG1/LAMC1/DPP4/ITGB1/CTSV/ADAMTS6/COL4A2/ADAMTS19/ADAMTS1/NF1/FERMT1/COL5A2/FBLN1/ST7/CCDC80/VWA1/SPINT1/SPINT2/PRDX4/LRP1/SERPINH1 25 GO:0007131 reciprocal meiotic recombination 8/896 58/18722 0.00612195689183324 0.050564398272685 TOP2A/RAD21/RAD51AP1/RAD51C/FANCD2/RAD51/MND1/RAD50 8 GO:0086065 cell communication involved in cardiac conduction 8/896 58/18722 0.00612195689183324 0.050564398272685 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/CALM2/DSC2 8 GO:0140527 reciprocal homologous recombination 8/896 58/18722 0.00612195689183324 0.050564398272685 TOP2A/RAD21/RAD51AP1/RAD51C/FANCD2/RAD51/MND1/RAD50 8 GO:1902808 positive regulation of cell cycle G1/S phase transition 8/896 58/18722 0.00612195689183324 0.050564398272685 EGFR/EZH2/CDC6/ADAMTS1/CCND1/TFDP1/RDX/EIF4G1 8 GO:0007265 Ras protein signal transduction 27/896 337/18722 0.00634949978268547 0.0522629516595524 STMN1/CCNA2/MET/HACD3/KPNB1/ADGRG1/ITGB1/NRP1/DHCR24/KANK1/GPSM2/KIF14/EPS8/FOXM1/ARFGEF3/NF1/ROCK2/ARHGAP5/CDKN2A/DNMT1/RDX/G3BP1/CDK2/NET1/CTNNAL1/TRIM28/RASA1 27 GO:0062197 cellular response to chemical stress 27/896 337/18722 0.00634949978268547 0.0522629516595524 CDK1/PCNA/MET/EGFR/ECT2/EZH2/BMP7/PARP1/DHFR/GPX8/PAWR/MELK/PKD2/FUT8/ATP2A2/SFPQ/NET1/P4HB/OXR1/PLEKHA1/STK24/HDAC2/SLC2A1/ETV5/NONO/XRCC5/XRCC6 27 GO:0072078 nephron tubule morphogenesis 9/896 71/18722 0.00658049655694254 0.0540710680943953 LAMA5/PKD2/DLG1/PBX1/LGR4/IRX2/AHI1/TACSTD2/MAGED1 9 GO:0070252 actin-mediated cell contraction 11/896 97/18722 0.00660765483591096 0.0542009350285892 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/EMP2/DLG1/ATP2A2/DSC2/AKAP9 11 GO:0045911 positive regulation of DNA recombination 7/896 47/18722 0.00663058677062418 0.0542957482726584 FUS/PARP1/RIF1/RAD51AP1/MSH2/TIMELESS/FANCB 7 GO:0061157 mRNA destabilization 10/896 84/18722 0.00670624662245362 0.0548212694787561 HNRNPR/EXOSC8/ROCK2/AGO2/HNRNPD/TNRC6A/DCP2/CNOT1/PUM1/KHSRP 10 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 28/896 355/18722 0.0067925691171192 0.0554320084873967 FBN2/LRP2/FBN1/BMP7/PARP1/TTK/SPTBN1/ITGB8/FSTL1/LTBP1/FUT8/CRIM1/GCNT2/CTDSPL2/FERMT1/ITGB5/GLG1/PEG10/TRIM33/ID1/ZNF451/HSPA5/TGFBR3/NREP/LRP1/USP9X/RBPJ/HSP90AB1 28 GO:0051016 barbed-end actin filament capping 5/896 26/18722 0.00705666425069729 0.0574889336737694 EPS8/SVIL/RDX/ADD3/TRIOBP 5 GO:0061337 cardiac conduction 11/896 98/18722 0.00713066592680633 0.0579928435001251 DSP/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/NUP155/CALM2/ATP2A2/DSC2/AKAP9 11 GO:0018394 peptidyl-lysine acetylation 16/896 169/18722 0.00723331720097546 0.0586279394184327 BRCA2/BRCA1/CHEK1/HAT1/SOX4/CTCF/YEATS4/BRD7/BRD8/SET/USP22/SMC5/ZNF451/HDAC2/NCOA3/EID1 16 GO:0021543 pallium development 16/896 169/18722 0.00723331720097546 0.0586279394184327 ASPM/LAMB1/EZH2/ADGRG1/ARHGAP11B/TACC3/KIF14/CNTNAP2/NF1/CDK6/SLC38A2/KIF5B/LRP1/SLC2A1/TRA2B/RTN4 16 GO:0030433 ubiquitin-dependent ERAD pathway 10/896 85/18722 0.0072837292123143 0.0589364801009974 HSP90B1/STT3B/CCDC47/UBE4B/HSPA5/CANX/CALR/UBE2G2/UBXN4/USP14 10 GO:0061647 histone H3-K9 modification 7/896 48/18722 0.007449724143652 0.0600601426338519 BRCA1/RIF1/CHEK1/DNMT1/ZNF451/ASH1L/ATRX 7 GO:0006289 nucleotide-excision repair 8/896 60/18722 0.00751752559564446 0.0600601426338519 HMGB1/BRCA2/RPA3/POLD3/RPA1/HMGN1/DDB1/RAD23B 8 GO:0007096 regulation of exit from mitosis 4/896 17/18722 0.00752324367302963 0.0600601426338519 UBE2C/ANLN/CDCA5/KNTC1 4 GO:0009200 deoxyribonucleoside triphosphate metabolic process 4/896 17/18722 0.00752324367302963 0.0600601426338519 TYMS/DUT/DTYMK/NUDT15 4 GO:0048532 anatomical structure arrangement 4/896 17/18722 0.00752324367302963 0.0600601426338519 NRP2/NRP1/KIF14/HSPA5 4 GO:0060977 coronary vasculature morphogenesis 4/896 17/18722 0.00752324367302963 0.0600601426338519 LRP2/NRP1/SETD2/TGFBR3 4 GO:0061450 trophoblast cell migration 4/896 17/18722 0.00752324367302963 0.0600601426338519 ITGB4/GJA1/AGO2/CALR 4 GO:0097067 cellular response to thyroid hormone stimulus 4/896 17/18722 0.00752324367302963 0.0600601426338519 GCLM/RDX/BRD8/CTSL 4 GO:0032355 response to estradiol 14/896 141/18722 0.00772698659117206 0.0615044662052367 PCNA/CCNA2/EGFR/EZH2/BMP7/NR2F2/GJA1/KIF18A/CCND1/SLC6A4/HNRNPD/DNMT3A/CALR/NCOA3 14 GO:0001667 ameboidal-type cell migration 35/896 475/18722 0.00772992872290365 0.0615044662052367 HMGB1/ANLN/MET/NRP2/BMP7/DPP4/ITGB1/NRP1/SEMA6D/LAMA5/NR2F2/ITGB4/GJA1/MARVELD3/AMOT/TPBG/KANK1/LRP5/FSTL1/EMP2/SEMA6A/NF1/ROCK2/FERMT1/AGO2/PTPRM/PKN2/AMOTL1/ID1/PDLIM1/MACF1/CALR/TACSTD2/SERPINF1/RTN4 35 GO:0072088 nephron epithelium morphogenesis 9/896 73/18722 0.00788433007550946 0.0625245710639238 LAMA5/PKD2/DLG1/PBX1/LGR4/IRX2/AHI1/TACSTD2/MAGED1 9 GO:0072089 stem cell proliferation 9/896 73/18722 0.00788433007550946 0.0625245710639238 HMGB2/RNF43/GJA1/ZNRF3/FERMT1/YAP1/FBLN1/HNRNPU/CCNE1 9 GO:0006473 protein acetylation 18/896 201/18722 0.00804085627085384 0.063660112499264 BRCA2/BRCA1/CHEK1/HAT1/CEP295/ESCO2/SOX4/CTCF/YEATS4/BRD7/BRD8/SET/USP22/SMC5/ZNF451/HDAC2/NCOA3/EID1 18 GO:0044728 DNA methylation or demethylation 11/896 100/18722 0.00827320714127909 0.0652711788682864 HELLS/EZH2/PARP1/BRCA1/MIS18A/DNMT1/CTCF/DNMT3A/TRIM28/USP9X/ATRX 11 GO:0030865 cortical cytoskeleton organization 8/896 61/18722 0.00829903761479888 0.0652711788682864 ANLN/ECT2/RACGAP1/DLG1/ROCK2/CALR/EPB41L3/RHOBTB3 8 GO:0034113 heterotypic cell-cell adhesion 8/896 61/18722 0.00829903761479888 0.0652711788682864 DSP/DSG2/PERP/BMP7/ITGAV/ITGB1/GCNT2/DSC2 8 GO:0090342 regulation of cell aging 8/896 61/18722 0.00829903761479888 0.0652711788682864 PRKDC/FBXO5/PAWR/FOXM1/RBL1/CDKN2A/CDK6/HMGA1 8 GO:0008038 neuron recognition 7/896 49/18722 0.00834131417283238 0.0652810391165603 APP/NRP1/CNTNAP2/NRCAM/PALLD/RTN4/BSG 7 GO:0070849 response to epidermal growth factor 7/896 49/18722 0.00834131417283238 0.0652810391165603 EGFR/MCM7/TPR/KNSTRN/ID1/IQGAP1/NCL 7 GO:0072091 regulation of stem cell proliferation 7/896 49/18722 0.00834131417283238 0.0652810391165603 HMGB2/GJA1/FERMT1/YAP1/FBLN1/HNRNPU/CCNE1 7 GO:0061136 regulation of proteasomal protein catabolic process 17/896 187/18722 0.00851709799498718 0.0665476691130422 AURKA/PBK/CDC20/XPO1/PLK1/NUDT15/SMARCC1/TMTC3/CDK2/FBXO22/RNF217/FMR1/USP14/UFL1/PSMD14/RAD23B/HSP90AB1 17 GO:0061014 positive regulation of mRNA catabolic process 10/896 87/18722 0.0085532951201599 0.0666124484561882 HNRNPR/EXOSC8/ROCK2/AGO2/HNRNPD/TNRC6A/DCP2/CNOT1/PUM1/KHSRP 10 GO:1901879 regulation of protein depolymerization 10/896 87/18722 0.0085532951201599 0.0666124484561882 TPX2/CKAP2/SPTBN1/EPS8/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP 10 GO:0097242 amyloid-beta clearance 6/896 38/18722 0.00878727766846783 0.0683232306014095 LRP2/MME/IGF1R/LRP1/LRPAP1/CLTC 6 GO:0048588 developmental cell growth 20/896 234/18722 0.00891213363809186 0.0691813430703261 AURKA/NRP2/APP/HSP90AA1/ITGB1/NRP1/SEMA6D/PARP2/SEMA6A/NRCAM/COBL/VCL/RYK/GOLGA4/IQGAP1/MACF1/LRP1/USP9X/RTN4/HSP90AB1 20 GO:0051098 regulation of binding 28/896 363/18722 0.0090662638193665 0.0702635446000903 HMGB2/STMN1/HMGB1/NUCKS1/MET/AURKA/APP/GMNN/PARP1/NRP1/AURKB/PLK1/CDT1/HJURP/NEK2/CALM2/ATP2A2/DHX9/ID1/TGFBR3/TRIM28/RAN/EIF4G1/FMR1/HDAC2/LRP1/LRPAP1/HSP90AB1 28 GO:0032785 negative regulation of DNA-templated transcription, elongation 4/896 18/18722 0.00931210175725844 0.0715877194672331 EZH2/TCERG1/RNF168/HNRNPU 4 GO:0051782 negative regulation of cell division 4/896 18/18722 0.00931210175725844 0.0715877194672331 ASPM/ORC6/AURKB/BLM 4 GO:0061484 hematopoietic stem cell homeostasis 4/896 18/18722 0.00931210175725844 0.0715877194672331 ADGRG1/FSTL1/SOX4/OCIAD1 4 GO:1901673 regulation of mitotic spindle assembly 4/896 18/18722 0.00931210175725844 0.0715877194672331 PLK1/KIF15/TPR/HNRNPU 4 GO:1902170 cellular response to reactive nitrogen species 4/896 18/18722 0.00931210175725844 0.0715877194672331 CCNA2/MTR/HNRNPD/CDK2 4 GO:0008088 axo-dendritic transport 9/896 75/18722 0.00937609274095213 0.0719637729024203 APP/KIF4A/DST/SFPQ/HNRNPU/DYNC1H1/KIF5B/PURA/HSPA8 9 GO:0001841 neural tube formation 11/896 102/18722 0.00955284161377491 0.0732026739392639 LRP2/KIF20B/BMP7/SOX4/FZD6/COBL/SETD2/SPINT1/SPINT2/ST14/LMO4 11 GO:0016049 cell growth 35/896 482/18722 0.00957528133902257 0.073257040244381 EGFR/AURKA/NRP2/APP/SMARCA2/HSP90AA1/ITGB1/NRP1/SEMA6D/CHPT1/GJA1/TMEM97/CLSTN1/KIF14/DCBLD2/PARP2/SEMA6A/NRCAM/CDKN2A/COBL/VCL/RYK/SMARCA4/GOLGA4/NET1/IQGAP1/MACF1/EIF4G1/EPB41L3/RBBP7/LRP1/USP9X/USP47/RTN4/HSP90AB1 35 GO:0000209 protein polyubiquitination 20/896 236/18722 0.00973959026273878 0.0743150572817085 UBE2C/UBE2S/UBE2T/BRCA1/BARD1/DTL/KLHL42/RNF168/SKP2/NEDD4/NHLRC3/FBXO22/UBE4B/NPEPPS/RNF217/HUWE1/CUL1/UBE2G2/ANAPC5/TRIM44 20 GO:0090344 negative regulation of cell aging 5/896 28/18722 0.009744705877325 0.0743150572817085 PRKDC/FBXO5/FOXM1/RBL1/CDK6 5 GO:0031507 heterochromatin assembly 6/896 39/18722 0.00997464965359487 0.0757926532318666 HELLS/TPR/DNMT1/DNMT3A/TRIM28/SMARCA5 6 GO:0051781 positive regulation of cell division 10/896 89/18722 0.00998608690465943 0.0757926532318666 KIF23/KIF20B/ECT2/AURKB/RACGAP1/CDC6/KIF14/SVIL/CIT/PKN2 10 GO:1900407 regulation of cellular response to oxidative stress 10/896 89/18722 0.00998608690465943 0.0757926532318666 MET/BMP7/PARP1/DHFR/PAWR/FUT8/SFPQ/P4HB/OXR1/NONO 10 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/896 131/18722 0.0100842854509025 0.0762913957712177 FBN2/LRP2/FBN1/LTBP1/CRIM1/CTDSPL2/GLG1/PEG10/TRIM33/ZNF451/HSPA5/TGFBR3/LRP1 13 GO:0002934 desmosome organization 3/896 10/18722 0.0101796437172739 0.0762913957712177 DSP/DSG2/PERP 3 GO:0009113 purine nucleobase biosynthetic process 3/896 10/18722 0.0101796437172739 0.0762913957712177 GMPS/PPAT/PAICS 3 GO:0030953 astral microtubule organization 3/896 10/18722 0.0101796437172739 0.0762913957712177 KPNB1/CENPJ/DLG1 3 GO:0035520 monoubiquitinated protein deubiquitination 3/896 10/18722 0.0101796437172739 0.0762913957712177 USP1/ASXL1/USP47 3 GO:0051660 establishment of centrosome localization 3/896 10/18722 0.0101796437172739 0.0762913957712177 MAD2L1/PARD3/DLG1 3 GO:1901978 positive regulation of cell cycle checkpoint 3/896 10/18722 0.0101796437172739 0.0762913957712177 MAD2L1/NDC80/TPR 3 GO:1902946 protein localization to early endosome 3/896 10/18722 0.0101796437172739 0.0762913957712177 NRP1/ROCK2/RDX 3 GO:0003279 cardiac septum development 11/896 103/18722 0.0102472557039313 0.076567556229939 LRP2/NRP2/BMP7/NRP1/GJA5/ADAMTS6/SOX4/TGFBR3/TRIP11/RBPJ/LMO4 11 GO:0042063 gliogenesis 24/896 301/18722 0.0102485690052222 0.076567556229939 LRP2/CDK1/LAMB1/EGFR/APP/DAG1/EZH2/ADGRG1/ITGB4/PARD3/NFIB/SOX4/NF1/DICER1/CDK6/SPINT1/HEXB/HDAC2/LRP1/ETV5/UFL1/IDH2/RHEB/RTN4 24 GO:0050821 protein stabilization 17/896 191/18722 0.0104027721523974 0.0775981785242897 HSP90AA1/MCM8/SOX4/TBL1X/CTNND1/USP27X/CALR/HSPD1/ATP1B3/USP9X/TRIM44/CCT5/CCT6A/CCT2/CCT4/RTN4/HSP90AB1 17 GO:0007409 axonogenesis 31/896 418/18722 0.0107314900575255 0.0799253253270309 STMN1/NRP2/APP/DAG1/BMP7/HSP90AA1/ITGB1/NRP1/SEMA6D/LAMA5/PARD3/ANK3/NFIB/SEMA6A/NRCAM/COBL/PTPRM/PALLD/VCL/PLXNB1/RYK/GOLGA4/MACF1/AFG3L2/PARD6B/KIF5B/LRP1/USP9X/RTN4/BSG/HSP90AB1 31 GO:0030837 negative regulation of actin filament polymerization 8/896 64/18722 0.0110097876378813 0.0817429645151559 SPTBN1/KANK1/KANK4/EPS8/SVIL/RDX/ADD3/TRIOBP 8 GO:0032507 maintenance of protein location in cell 8/896 64/18722 0.0110097876378813 0.0817429645151559 BARD1/GJA1/ANK3/VPS13A/GPAA1/TAF3/HNRNPU/HSPA5 8 GO:0055117 regulation of cardiac muscle contraction 9/896 77/18722 0.0110717115289217 0.0820750789426588 DSP/DSG2/GJA5/ATP1A1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 9 GO:1903362 regulation of cellular protein catabolic process 21/896 255/18722 0.0111680343007033 0.0826607686070662 LRP2/AURKA/PBK/CDC20/HSP90AA1/XPO1/PLK1/NUDT15/SMARCC1/TMTC3/RDX/CDK2/FBXO22/RNF217/FMR1/LRP1/USP14/UFL1/PSMD14/RAD23B/HSP90AB1 21 GO:0014037 Schwann cell differentiation 6/896 40/18722 0.0112717544130699 0.0830422153827095 CDK1/DAG1/ITGB4/PARD3/NF1/DICER1 6 GO:0035329 hippo signaling 6/896 40/18722 0.0112717544130699 0.0830422153827095 AMOT/TEAD1/CIT/YAP1/DLG5/AMOTL1 6 GO:0071526 semaphorin-plexin signaling pathway 6/896 40/18722 0.0112717544130699 0.0830422153827095 MET/NRP2/NRP1/SEMA6D/SEMA6A/PLXNB1 6 GO:0022011 myelination in peripheral nervous system 5/896 29/18722 0.0113211663441399 0.0831496125029598 DAG1/ITGB4/PARD3/NF1/DICER1 5 GO:0032292 peripheral nervous system axon ensheathment 5/896 29/18722 0.0113211663441399 0.0831496125029598 DAG1/ITGB4/PARD3/NF1/DICER1 5 GO:0045947 negative regulation of translational initiation 4/896 19/18722 0.0113563579717334 0.0832799584593783 TPR/AGO2/LARP1/FMR1 4 GO:0035148 tube formation 14/896 148/18722 0.0116012535475884 0.0849453749021272 LRP2/KIF20B/BMP7/NFIB/SOX4/FZD6/COBL/IRX2/SETD2/SPINT1/SPINT2/ST14/TGM2/LMO4 14 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 21/896 256/18722 0.011637602048802 0.0850810293736306 FBN2/LRP2/FBN1/BMP7/PARP1/TTK/FSTL1/LTBP1/CRIM1/CTDSPL2/FERMT1/GLG1/PEG10/TRIM33/ZNF451/HSPA5/TGFBR3/NREP/LRP1/RBPJ/HSP90AB1 21 GO:1901654 response to ketone 17/896 194/18722 0.0120233723040272 0.0877596072380526 TYMS/PCNA/NASP/EGFR/ATP2B1/PARP1/CCND1/ROCK2/YAP1/HNRNPD/MTAP/TGFBR3/CALR/LARP1/GLB1/SERPINF1/CLDN4 17 GO:0043489 RNA stabilization 8/896 65/18722 0.0120441071365396 0.0877596072380526 FUS/HNRNPD/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/THRAP3 8 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 13/896 134/18722 0.012059133294546 0.0877596072380526 AURKA/PBK/CDC20/XPO1/PLK1/SMARCC1/CDK2/FBXO22/RNF217/USP14/UFL1/RAD23B/HSP90AB1 13 GO:0090263 positive regulation of canonical Wnt signaling pathway 11/896 106/18722 0.0125643392765496 0.0912970406487789 ASPM/EGFR/LGR5/WLS/KANK1/SOX4/YAP1/LGR4/TBL1X/USP47/RBPJ 11 GO:0031062 positive regulation of histone methylation 6/896 41/18722 0.0126835388889186 0.0917442646298448 BRCA1/RIF1/MTF2/DNMT1/PAXBP1/BRD4 6 GO:0051693 actin filament capping 6/896 41/18722 0.0126835388889186 0.0917442646298448 SPTBN1/EPS8/SVIL/RDX/ADD3/TRIOBP 6 GO:0055023 positive regulation of cardiac muscle tissue growth 6/896 41/18722 0.0126835388889186 0.0917442646298448 CCNB1/CDK1/PARP2/YAP1/TGFBR3/RBPJ 6 GO:2000772 regulation of cellular senescence 7/896 53/18722 0.0127034453158644 0.0917492404507359 PRKDC/FBXO5/PAWR/RBL1/CDKN2A/CDK6/HMGA1 7 GO:0000245 spliceosomal complex assembly 9/896 79/18722 0.0129871307122994 0.0935151765015346 PSIP1/SRPK1/SRSF10/SF1/LUC7L3/SNRPD1/SCAF11/SNRPG/SRSF5 9 GO:0032272 negative regulation of protein polymerization 9/896 79/18722 0.0129871307122994 0.0935151765015346 STMN1/SPTBN1/KANK1/KANK4/EPS8/SVIL/RDX/ADD3/TRIOBP 9 GO:0031571 mitotic G1 DNA damage checkpoint signaling 5/896 30/18722 0.0130626959598825 0.0939176363139747 GTSE1/PRKDC/SOX4/CCND1/CDK2 5 GO:0016358 dendrite development 20/896 243/18722 0.0131336139543503 0.0942855233354409 APP/CDC20/EZH2/BMP7/ITGB1/NRP1/TPBG/YWHAH/COBL/VLDLR/PPP1R9A/RERE/DLG5/NEDD4/CAMSAP2/ID1/IQGAP1/FMR1/ASAP1/HDAC2 20 GO:0001838 embryonic epithelial tube formation 12/896 121/18722 0.0131865111106614 0.0945231291926388 LRP2/KIF20B/BMP7/SOX4/FZD6/COBL/IRX2/SETD2/SPINT1/SPINT2/ST14/LMO4 12 GO:0003093 regulation of glomerular filtration 3/896 11/18722 0.0135049485250788 0.0956567125500385 GJA5/GJA1/EMP2 3 GO:0007144 female meiosis I 3/896 11/18722 0.0135049485250788 0.0956567125500385 AURKA/CCNB2/FBXO5 3 GO:0032329 serine transport 3/896 11/18722 0.0135049485250788 0.0956567125500385 SFXN1/SLC38A2/SLC1A5 3 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 3/896 11/18722 0.0135049485250788 0.0956567125500385 PARP1/YAP1/SKP2 3 GO:0033327 Leydig cell differentiation 3/896 11/18722 0.0135049485250788 0.0956567125500385 CCND1/SF1/PLEKHA1 3 GO:0070601 centromeric sister chromatid cohesion 3/896 11/18722 0.0135049485250788 0.0956567125500385 BUB1B/BUB1/CTCF 3 GO:1903961 positive regulation of anion transmembrane transport 3/896 11/18722 0.0135049485250788 0.0956567125500385 TCAF1/ITGB1/ARL6IP1 3 GO:2000615 regulation of histone H3-K9 acetylation 3/896 11/18722 0.0135049485250788 0.0956567125500385 BRCA1/CHEK1/ZNF451 3 GO:0003158 endothelium development 13/896 136/18722 0.0135332543850353 0.0957151947172716 MET/NRP1/NR2F2/GJA5/GJA1/FSTL1/APOLD1/ROCK2/MARVELD2/RDX/VCL/ID1/RBPJ 13 GO:0048592 eye morphogenesis 14/896 151/18722 0.0136648084075522 0.0957321414160874 FBN2/EFEMP1/FBN1/TENM3/BMP7/FAT1/LRP5/FZD5/NF1/PTPRM/COL5A2/AHI1/TUG1/HMGN1 14 GO:0048754 branching morphogenesis of an epithelial tube 14/896 151/18722 0.0136648084075522 0.0957321414160874 MET/DAG1/BMP7/NRP1/LAMA5/LRP5/PKD2/DLG1/PBX1/YAP1/LGR4/DLG5/TACSTD2/MAGED1 14 GO:0006346 DNA methylation-dependent heterochromatin assembly 4/896 20/18722 0.0136681351641767 0.0957321414160874 HELLS/DNMT1/DNMT3A/TRIM28 4 GO:0006607 NLS-bearing protein import into nucleus 4/896 20/18722 0.0136681351641767 0.0957321414160874 KPNA2/KPNB1/IPO5/RANBP2 4 GO:0071731 response to nitric oxide 4/896 20/18722 0.0136681351641767 0.0957321414160874 CCNA2/MTR/HNRNPD/CDK2 4 GO:2000757 negative regulation of peptidyl-lysine acetylation 4/896 20/18722 0.0136681351641767 0.0957321414160874 BRCA1/SET/ZNF451/HDAC2 4 GO:0090150 establishment of protein localization to membrane 21/896 260/18722 0.0136760202022982 0.0957321414160874 EGFR/TCAF1/HSP90AA1/SPTBN1/CLSTN1/PARD3/ANK3/ICMT/RAB3IP/ARL6IP1/MYO1C/CCDC47/TRAM2/EMC1/ZDHHC12/GOLGA4/SEC63/MACF1/HSPA5/GOPC/CD24 21 GO:0030520 intracellular estrogen receptor signaling pathway 7/896 54/18722 0.0140103877995697 0.09750086203374 PARP1/BRCA1/YAP1/SKP2/CNOT1/UFL1/DDX17 7 GO:0030834 regulation of actin filament depolymerization 7/896 54/18722 0.0140103877995697 0.09750086203374 SPTBN1/EPS8/SVIL/RDX/ADD3/LIMA1/TRIOBP 7 GO:0035065 regulation of histone acetylation 7/896 54/18722 0.0140103877995697 0.09750086203374 BRCA1/CHEK1/CTCF/BRD7/SET/ZNF451/EID1 7 GO:0072698 protein localization to microtubule cytoskeleton 7/896 54/18722 0.0140103877995697 0.09750086203374 KIF20B/AURKA/TTK/CCDC14/PCM1/GOLGB1/HNRNPU 7 GO:0001649 osteoblast differentiation 19/896 229/18722 0.0142136828390885 0.0984926962649577 FBN2/RRBP1/BMP7/FBXO5/LRP5/FIGNL1/CRIM1/NF1/YAP1/LGR4/RBMX/SUCO/CDK6/DHX9/CCDC47/HNRNPU/SYNCRIP/UFL1/CLTC 19 GO:0009124 nucleoside monophosphate biosynthetic process 6/896 42/18722 0.014214802623912 0.0984926962649577 TYMS/DUT/TK1/GMPS/PPAT/PAICS 6 GO:0072595 maintenance of protein localization in organelle 6/896 42/18722 0.014214802623912 0.0984926962649577 BARD1/GJA1/GPAA1/TAF3/HNRNPU/HSPA5 6 GO:0098656 anion transmembrane transport 20/896 245/18722 0.0142583708753002 0.0986513950125841 LRP2/TCAF1/ITGB1/SLC20A1/GJA1/SLC35B4/SFXN1/GABRE/SLC16A1/SLC26A2/SLC16A12/ARL6IP1/SLC35D1/SLC1A5/ANKH/SLC25A1/GOPC/ANO6/SLC13A3/SLC25A5 20 GO:0014020 primary neural tube formation 10/896 94/18722 0.0143650918116417 0.0992459454540915 LRP2/KIF20B/BMP7/FZD6/COBL/SETD2/SPINT1/SPINT2/ST14/LMO4 10 GO:0051402 neuron apoptotic process 20/896 246/18722 0.0148485611552733 0.102437906004732 APP/PARP1/NRP1/KIF14/MSH2/XRCC2/MYBL2/CIT/NF1/GCLM/NAE1/SET/USP53/HSPA5/OXR1/HSPD1/LRP1/NONO/RASA1/HSP90AB1 20 GO:0010811 positive regulation of cell-substrate adhesion 12/896 123/18722 0.0148728737205847 0.102457574519583 ITGA6/DAG1/NRP1/EMP2/UTRN/FERMT1/CDK6/CCDC80/IQGAP1/P4HB/CALR/TRIOBP 12 GO:0044819 mitotic G1/S transition checkpoint signaling 5/896 31/18722 0.014976367503231 0.102578448293293 GTSE1/PRKDC/SOX4/CCND1/CDK2 5 GO:0060045 positive regulation of cardiac muscle cell proliferation 5/896 31/18722 0.014976367503231 0.102578448293293 CCNB1/CDK1/YAP1/TGFBR3/RBPJ 5 GO:0071711 basement membrane organization 5/896 31/18722 0.014976367503231 0.102578448293293 LAMB1/DAG1/ITGB1/FERMT1/SPINT2 5 GO:1900027 regulation of ruffle assembly 5/896 31/18722 0.014976367503231 0.102578448293293 KANK1/EPS8/COBL/RDX/TACSTD2 5 GO:0071260 cellular response to mechanical stimulus 9/896 81/18722 0.0151381795350717 0.103538207880276 EGFR/DAG1/GJA1/CHEK1/ATP1A1/CASP8AP2/SLC38A2/TMEM150C/SLC2A1 9 GO:0003018 vascular process in circulatory system 21/896 263/18722 0.0153830613665802 0.104950904785019 LRP2/EGFR/ATP2B1/SLC29A1/SLC38A1/GJA5/GJA1/ADRB1/SLC6A4/SLC16A1/SLC5A3/GCLM/ROCK2/SLC16A12/SLC38A2/SLC44A1/SLC1A5/YES1/LRP1/SLC2A1/SLC13A3 21 GO:0031113 regulation of microtubule polymerization 7/896 55/18722 0.0154106795673017 0.104950904785019 STMN1/MET/CKAP5/CDK5RAP2/CAMSAP2/CLIP1/AKAP9 7 GO:0042220 response to cocaine 7/896 55/18722 0.0154106795673017 0.104950904785019 CCNA2/DNMT3A/HSPA5/HSPD1/HDAC2/TGM2/HSP90AB1 7 GO:0061383 trabecula morphogenesis 6/896 43/18722 0.0158701785679949 0.107926257099156 FBN2/BMP7/ADAMTS1/PLXNB1/TGFBR3/RBPJ 6 GO:0043434 response to peptide hormone 30/896 414/18722 0.0160255059820958 0.108827547024929 CCNA2/GGH/PRKDC/NUCKS1/FBN1/ATP2B1/DAG1/BMP7/PARP1/CDC6/GJA1/KANK1/IGF1R/PHIP/LRP5/SOGA1/PPAT/ROCK2/SMARCC1/SNX5/AHCYL1/SRSF4/MYO1C/IQGAP1/TGFBR3/HADHA/SLC2A1/CACYBP/BSG/SRSF5 30 GO:0019985 translesion synthesis 4/896 21/18722 0.016258153960368 0.109782782187832 PCNA/DTL/REV1/USP10 4 GO:0046599 regulation of centriole replication 4/896 21/18722 0.016258153960368 0.109782782187832 BRCA1/CEP295/CENPJ/CDK5RAP2 4 GO:0048485 sympathetic nervous system development 4/896 21/18722 0.016258153960368 0.109782782187832 NRP2/NRP1/SOX4/NF1 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/896 21/18722 0.016258153960368 0.109782782187832 SLC6A4/NF1/SPINT1/SPINT2 4 GO:1904375 regulation of protein localization to cell periphery 12/896 125/18722 0.0167179885403528 0.112550057382673 EGFR/DAG1/ITGB1/PLK1/SPTBN1/GPSM2/DLG1/GOPC/KIF5B/LRP1/PPFIA1/CLTC 12 GO:0030177 positive regulation of Wnt signaling pathway 13/896 140/18722 0.0168927058505237 0.112550057382673 ASPM/EGFR/LGR5/WLS/KANK1/SOX4/YAP1/LGR4/SMARCA4/TBL1X/MACF1/USP47/RBPJ 13 GO:0031333 negative regulation of protein-containing complex assembly 13/896 140/18722 0.0168927058505237 0.112550057382673 STMN1/HMGB1/SPTBN1/KANK1/KANK4/KIF14/EPS8/SVIL/RDX/ADD3/HSPA5/TRIOBP/LMO4 13 GO:0050768 negative regulation of neurogenesis 13/896 140/18722 0.0168927058505237 0.112550057382673 BMP7/NRP1/SEMA6D/PRTG/SEMA6A/YWHAH/NF1/DICER1/PCM1/RYK/ID1/IDH2/RTN4 13 GO:0031060 regulation of histone methylation 8/896 69/18722 0.0169031891003955 0.112550057382673 BRCA1/RIF1/MTF2/DNMT1/CTCF/PAXBP1/BRD4/ATRX 8 GO:0001658 branching involved in ureteric bud morphogenesis 7/896 56/18722 0.0169075820871591 0.112550057382673 LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 7 GO:0031529 ruffle organization 7/896 56/18722 0.0169075820871591 0.112550057382673 KANK1/EPS8/COBL/RDX/PLEKHA1/TACSTD2/LIMA1 7 GO:0006335 DNA replication-dependent nucleosome assembly 5/896 32/18722 0.017068806442193 0.112550057382673 NASP/HAT1/ASF1B/CHAF1A/RBBP4 5 GO:0010644 cell communication by electrical coupling 5/896 32/18722 0.017068806442193 0.112550057382673 GJA5/GJA1/ATP1A1/ANK3/CALM2 5 GO:0014044 Schwann cell development 5/896 32/18722 0.017068806442193 0.112550057382673 DAG1/ITGB4/PARD3/NF1/DICER1 5 GO:0034723 DNA replication-dependent nucleosome organization 5/896 32/18722 0.017068806442193 0.112550057382673 NASP/HAT1/ASF1B/CHAF1A/RBBP4 5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 5/896 32/18722 0.017068806442193 0.112550057382673 IPO7/NR2F2/PLK1/IPO5/CDKN2A 5 GO:0051497 negative regulation of stress fiber assembly 5/896 32/18722 0.017068806442193 0.112550057382673 STMN1/MET/PPP1R9A/TACSTD2/PPFIA1 5 GO:0072337 modified amino acid transport 5/896 32/18722 0.017068806442193 0.112550057382673 LRP2/GJA1/SLC16A12/SLC38A2/SLC13A3 5 GO:0009265 2'-deoxyribonucleotide biosynthetic process 3/896 12/18722 0.0173752392733619 0.112550057382673 TYMS/DUT/DTYMK 3 GO:0010826 negative regulation of centrosome duplication 3/896 12/18722 0.0173752392733619 0.112550057382673 BRCA1/CDK5RAP2/CCNF 3 GO:0031453 positive regulation of heterochromatin assembly 3/896 12/18722 0.0173752392733619 0.112550057382673 TPR/DNMT1/TRIM28 3 GO:0034086 maintenance of sister chromatid cohesion 3/896 12/18722 0.0173752392733619 0.112550057382673 SLF2/SMC5/ATRX 3 GO:0034088 maintenance of mitotic sister chromatid cohesion 3/896 12/18722 0.0173752392733619 0.112550057382673 SLF2/SMC5/ATRX 3 GO:0043696 dedifferentiation 3/896 12/18722 0.0173752392733619 0.112550057382673 HNRNPD/CDK6/NCOA3 3 GO:0043697 cell dedifferentiation 3/896 12/18722 0.0173752392733619 0.112550057382673 HNRNPD/CDK6/NCOA3 3 GO:0046385 deoxyribose phosphate biosynthetic process 3/896 12/18722 0.0173752392733619 0.112550057382673 TYMS/DUT/DTYMK 3 GO:0046606 negative regulation of centrosome cycle 3/896 12/18722 0.0173752392733619 0.112550057382673 BRCA1/CDK5RAP2/CCNF 3 GO:0051095 regulation of helicase activity 3/896 12/18722 0.0173752392733619 0.112550057382673 MSH6/MSH2/MCM2 3 GO:0070493 thrombin-activated receptor signaling pathway 3/896 12/18722 0.0173752392733619 0.112550057382673 STMN1/MET/IQGAP2 3 GO:0071635 negative regulation of transforming growth factor beta production 3/896 12/18722 0.0173752392733619 0.112550057382673 CD2AP/CD24/HSP90AB1 3 GO:0072520 seminiferous tubule development 3/896 12/18722 0.0173752392733619 0.112550057382673 ADGRG1/KIF18A/ATRX 3 GO:0120263 positive regulation of heterochromatin organization 3/896 12/18722 0.0173752392733619 0.112550057382673 TPR/DNMT1/TRIM28 3 GO:1905214 regulation of RNA binding 3/896 12/18722 0.0173752392733619 0.112550057382673 NUCKS1/EIF4G1/FMR1 3 GO:2000105 positive regulation of DNA-dependent DNA replication 3/896 12/18722 0.0173752392733619 0.112550057382673 DBF4/CDT1/ATRX 3 GO:0060711 labyrinthine layer development 6/896 44/18722 0.0176541151514076 0.114201552483496 BMP7/FZD5/SPINT1/SPINT2/ST14/RBPJ 6 GO:1990778 protein localization to cell periphery 25/896 333/18722 0.01785189985881 0.115324722497915 CDH1/EGFR/DAG1/ITGB1/LAMA5/PLK1/SPTBN1/TPBG/GPSM2/CLSTN1/ANK3/EMP2/DLG1/ROCK2/RDX/GOLGA4/MACF1/GOPC/KIF5B/EPB41L3/ATP1B3/LRP1/PPFIA1/CLTC/BSG 25 GO:0048736 appendage development 15/896 172/18722 0.0183046244021919 0.117930198240303 FBN2/ITGA6/BMP7/NR2F2/ITGB4/LRP5/FRAS1/FREM2/SOX4/ZNRF3/PBX1/FZD6/SLC39A1/HDAC2/ATRX 15 GO:0060173 limb development 15/896 172/18722 0.0183046244021919 0.117930198240303 FBN2/ITGA6/BMP7/NR2F2/ITGB4/LRP5/FRAS1/FREM2/SOX4/ZNRF3/PBX1/FZD6/SLC39A1/HDAC2/ATRX 15 GO:0016447 somatic recombination of immunoglobulin gene segments 7/896 57/18722 0.018504265277289 0.118895507986242 PRKDC/RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 7 GO:1900024 regulation of substrate adhesion-dependent cell spreading 7/896 57/18722 0.018504265277289 0.118895507986242 NRP1/KANK1/FBLN1/P4HB/CALR/TACSTD2/TRIOBP 7 GO:0001837 epithelial to mesenchymal transition 14/896 157/18722 0.0186311137552022 0.119549646595881 HNRNPAB/DAG1/EZH2/BMP7/TCOF1/GCNT2/ROCK2/DLG5/TGFBR3/TRIM28/HDAC2/RBPJ/DDX17/RTN4 14 GO:1902882 regulation of response to oxidative stress 10/896 98/18722 0.0187920396526493 0.120420399062749 MET/BMP7/PARP1/DHFR/PAWR/FUT8/SFPQ/P4HB/OXR1/NONO 10 GO:0006405 RNA export from nucleus 9/896 84/18722 0.0188405425749038 0.120569370311784 NUP155/NUP107/TPR/HNRNPA2B1/DHX9/SETD2/KHDRBS1/RAN/PABPN1 9 GO:0071383 cellular response to steroid hormone stimulus 17/896 204/18722 0.0188996850995707 0.120624460782554 EGFR/ATP2B1/BMP7/PARP1/BRCA1/ATP1A1/YWHAH/YAP1/SKP2/NEDD4/SMARCA4/HNRNPU/CNOT1/CALR/UFL1/SERPINF1/DDX17 17 GO:1901888 regulation of cell junction assembly 17/896 204/18722 0.0188996850995707 0.120624460782554 APP/NRP1/GJA1/TPBG/CLSTN1/CNTNAP2/FZD5/ROCK2/PPP1R9A/DLG5/MYO1C/VCL/IQGAP1/MACF1/SLK/EIF4G1/LRP1 17 GO:0048762 mesenchymal cell differentiation 19/896 236/18722 0.0189361138276764 0.120695604023134 HNRNPAB/NRP2/DAG1/EZH2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A/GCNT2/ROCK2/DLG5/TGFBR3/TRIM28/HDAC2/RBPJ/DDX17/RTN4 19 GO:0032727 positive regulation of interferon-alpha production 4/896 22/18722 0.0191357141014442 0.121319919150458 HMGB1/DHX9/SETD2/HSPD1 4 GO:0034629 cellular protein-containing complex localization 4/896 22/18722 0.0191357141014442 0.121319919150458 NDC1/DLG1/MZT1/AKAP9 4 GO:0035024 negative regulation of Rho protein signal transduction 4/896 22/18722 0.0191357141014442 0.121319919150458 STMN1/MET/ITGB1/KANK1 4 GO:2000773 negative regulation of cellular senescence 4/896 22/18722 0.0191357141014442 0.121319919150458 PRKDC/FBXO5/RBL1/CDK6 4 GO:0003382 epithelial cell morphogenesis 5/896 33/18722 0.0193461630530366 0.121684561811853 MET/FAT1/PALLD/SPINT2/ST14 5 GO:0010259 multicellular organism aging 5/896 33/18722 0.0193461630530366 0.121684561811853 CTSV/MSH6/MSH2/TFCP2L1/SEC63 5 GO:0031116 positive regulation of microtubule polymerization 5/896 33/18722 0.0193461630530366 0.121684561811853 MET/CKAP5/CDK5RAP2/CLIP1/AKAP9 5 GO:0048048 embryonic eye morphogenesis 5/896 33/18722 0.0193461630530366 0.121684561811853 FBN2/EFEMP1/FBN1/BMP7/FZD5 5 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 5/896 33/18722 0.0193461630530366 0.121684561811853 IPO7/NR2F2/PLK1/IPO5/CDKN2A 5 GO:2000036 regulation of stem cell population maintenance 5/896 33/18722 0.0193461630530366 0.121684561811853 BMP7/ZC3H13/YAP1/CNOT1/NCOA3 5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 6/896 45/18722 0.0195708596741188 0.122329826824096 PARP1/MELK/SFPQ/P4HB/STK24/NONO 6 GO:0035987 endodermal cell differentiation 6/896 45/18722 0.0195708596741188 0.122329826824096 LAMB1/ITGAV/COL4A2/COL5A2/ITGB5/SETD2 6 GO:0060421 positive regulation of heart growth 6/896 45/18722 0.0195708596741188 0.122329826824096 CCNB1/CDK1/PARP2/YAP1/TGFBR3/RBPJ 6 GO:0071364 cellular response to epidermal growth factor stimulus 6/896 45/18722 0.0195708596741188 0.122329826824096 EGFR/MCM7/KNSTRN/ID1/IQGAP1/NCL 6 GO:0018393 internal peptidyl-lysine acetylation 14/896 158/18722 0.0195768721603706 0.122329826824096 BRCA2/BRCA1/CHEK1/HAT1/CTCF/YEATS4/BRD7/BRD8/SET/USP22/SMC5/ZNF451/NCOA3/EID1 14 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 12/896 128/18722 0.0198020981491613 0.123575446489014 FBN2/FBN1/LTBP1/FERMT1/GLG1/PEG10/TRIM33/ZNF451/HSPA5/TGFBR3/NREP/HSP90AB1 12 GO:0001954 positive regulation of cell-matrix adhesion 7/896 58/18722 0.020203797800783 0.125459432313563 DAG1/NRP1/EMP2/UTRN/FERMT1/CDK6/IQGAP1 7 GO:0032481 positive regulation of type I interferon production 7/896 58/18722 0.020203797800783 0.125459432313563 HMGB2/HMGB1/HSP90AA1/G3BP1/DHX9/SETD2/HSPD1 7 GO:0044380 protein localization to cytoskeleton 7/896 58/18722 0.020203797800783 0.125459432313563 KIF20B/AURKA/TTK/CCDC14/PCM1/GOLGB1/HNRNPU 7 GO:0001656 metanephros development 9/896 85/18722 0.0202091125783683 0.125459432313563 FBN1/BMP7/FRAS1/PKD2/NF1/YAP1/LGR4/IRX2/DLG5 9 GO:0009896 positive regulation of catabolic process 34/896 492/18722 0.0206501963104529 0.128031217124808 LRP2/HMGB1/AURKA/APP/CDC20/HNRNPR/HSP90AA1/BARD1/DTL/GJA1/PLK1/EXOSC8/LIN28B/ROCK2/AGO2/TMTC3/RDX/KCNQ1OT1/HNRNPD/NEDD4/FBXO22/TNRC6A/DCP2/CNOT1/RNF217/HUWE1/LARP1/PUM1/KHSRP/FMR1/LRP1/UFL1/DDB1/SLC25A5 34 GO:0097193 intrinsic apoptotic signaling pathway 22/896 288/18722 0.0211288880406756 0.130829197803094 HELLS/BRCA2/PRKDC/PERP/PARP1/BRCA1/MSH6/MSH2/MELK/RTKN2/FIGNL1/SFPQ/P4HB/HINT1/TMEM109/CUL1/STK24/USP47/NONO/BCLAF1/CD24/ERP29 22 GO:0033627 cell adhesion mediated by integrin 8/896 72/18722 0.0213741834781977 0.131656714086048 FBN1/ITGAV/DPP4/ITGB1/ITGB4/ITGB8/FERMT1/ITGB5 8 GO:0006475 internal protein amino acid acetylation 14/896 160/18722 0.0215766574428088 0.131656714086048 BRCA2/BRCA1/CHEK1/HAT1/CTCF/YEATS4/BRD7/BRD8/SET/USP22/SMC5/ZNF451/NCOA3/EID1 14 GO:0035637 multicellular organismal signaling 14/896 160/18722 0.0215766574428088 0.131656714086048 DSP/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/ANK3/CNTNAP2/NUP155/CALM2/ATP2A2/DSC2/AKAP9/FMR1 14 GO:0050919 negative chemotaxis 6/896 46/18722 0.02162444304825 0.131656714086048 NRP2/ITGAV/DPP4/SEMA6D/SEMA6A/RYK 6 GO:0048864 stem cell development 9/896 86/18722 0.0216479693649499 0.131656714086048 NRP2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A/MSI2/SETD2 9 GO:0010038 response to metal ion 27/896 373/18722 0.0217600283576821 0.131656714086048 CCNB1/CDK1/PCNA/CDH1/GGH/FUS/EGFR/ECT2/APP/PARP1/DTYMK/ANK3/PKD2/MT2A/CCND1/CALM2/AHCYL1/HNRNPD/NEDD4/DNMT3A/IQGAP1/HSPA5/CALR/SERPINF1/CACYBP/CYB5A/BSG 27 GO:0001833 inner cell mass cell proliferation 3/896 13/18722 0.0217979204232599 0.131656714086048 BRCA2/CHEK1/NCAPG2 3 GO:0010960 magnesium ion homeostasis 3/896 13/18722 0.0217979204232599 0.131656714086048 EGFR/ANK3/TRPM7 3 GO:0016246 RNA interference 3/896 13/18722 0.0217979204232599 0.131656714086048 AGO2/DICER1/DHX9 3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 3/896 13/18722 0.0217979204232599 0.131656714086048 SUPT16H/TCERG1/BRD4 3 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 3/896 13/18722 0.0217979204232599 0.131656714086048 PARP1/YAP1/SKP2 3 GO:0033262 regulation of nuclear cell cycle DNA replication 3/896 13/18722 0.0217979204232599 0.131656714086048 DBF4/CDT1/ATRX 3 GO:0043970 histone H3-K9 acetylation 3/896 13/18722 0.0217979204232599 0.131656714086048 BRCA1/CHEK1/ZNF451 3 GO:0048012 hepatocyte growth factor receptor signaling pathway 3/896 13/18722 0.0217979204232599 0.131656714086048 STMN1/MET/NRP1 3 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/896 13/18722 0.0217979204232599 0.131656714086048 AGO2/TNRC6A/CNOT1 3 GO:0098814 spontaneous synaptic transmission 3/896 13/18722 0.0217979204232599 0.131656714086048 APP/ITGB1/PPP1R9A 3 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 3/896 13/18722 0.0217979204232599 0.131656714086048 NRP2/NRP1/PLXNB1 3 GO:1905269 positive regulation of chromatin organization 3/896 13/18722 0.0217979204232599 0.131656714086048 TPR/DNMT1/TRIM28 3 GO:0009112 nucleobase metabolic process 5/896 34/18722 0.0218140889907968 0.131656714086048 TYMS/RRM1/GMPS/PPAT/PAICS 5 GO:2000780 negative regulation of double-strand break repair 5/896 34/18722 0.0218140889907968 0.131656714086048 RIF1/POLQ/RMI2/FANCB/PARPBP 5 GO:0034976 response to endoplasmic reticulum stress 20/896 256/18722 0.0218661184259304 0.131804102734081 HSP90B1/PDIA4/CCND1/ATP2A2/STT3B/TMTC3/CCDC47/TMX1/PDIA3/P4HB/UBE4B/HSPA5/CANX/CALR/EIF4G1/UBE2G2/UBXN4/USP14/UFL1/ERP29 20 GO:0051961 negative regulation of nervous system development 13/896 145/18722 0.0219386405396505 0.132074489200872 BMP7/NRP1/SEMA6D/PRTG/SEMA6A/YWHAH/NF1/DICER1/PCM1/RYK/ID1/IDH2/RTN4 13 GO:0030042 actin filament depolymerization 7/896 59/18722 0.0220091378374393 0.132332020196392 SPTBN1/EPS8/SVIL/RDX/ADD3/LIMA1/TRIOBP 7 GO:0006541 glutamine metabolic process 4/896 23/18722 0.0223086918718644 0.133460770672031 ARHGAP11B/GMPS/PPAT/GFPT1 4 GO:0051131 chaperone-mediated protein complex assembly 4/896 23/18722 0.0223086918718644 0.133460770672031 HSP90AA1/HSPD1/CCT2/HSP90AB1 4 GO:0071514 genetic imprinting 4/896 23/18722 0.0223086918718644 0.133460770672031 BRCA1/CTCF/DNMT3A/TRIM28 4 GO:2000810 regulation of bicellular tight junction assembly 4/896 23/18722 0.0223086918718644 0.133460770672031 GJA1/FZD5/ROCK2/MYO1C 4 GO:0032956 regulation of actin cytoskeleton organization 26/896 357/18722 0.0224479252270636 0.134125650856072 STMN1/MET/ECT2/IQGAP2/NRP1/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/ROCK2/PPP1R9A/RDX/MYO1C/ID1/IQGAP1/ADD3/TACSTD2/CD2AP/LRP1/LIMA1/PPFIA1/TRIOBP/RHOBTB3/RASA1 26 GO:0003205 cardiac chamber development 14/896 161/18722 0.0226322399609849 0.135057891967178 LRP2/DSP/NRP2/BMP7/NRP1/GJA5/ADAMTS6/ADAMTS1/SOX4/TGFBR3/LY6E/TRIP11/RBPJ/LMO4 14 GO:2000177 regulation of neural precursor cell proliferation 9/896 87/18722 0.0231588933162719 0.138028160664022 ASPM/LRP2/ADGRG1/SHCBP1/SLC6A4/NF1/NAP1L1/SPINT1/SPINT2 9 GO:0030518 intracellular steroid hormone receptor signaling pathway 11/896 116/18722 0.0232116532366741 0.138170115401349 PARP1/BRCA1/YWHAH/YAP1/SKP2/NEDD4/SMARCA4/CNOT1/CALR/UFL1/DDX17 11 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 12/896 131/18722 0.0232912785182975 0.138471436670426 FBN2/FBN1/LTBP1/FERMT1/GLG1/PEG10/TRIM33/ZNF451/HSPA5/TGFBR3/NREP/HSP90AB1 12 GO:0010799 regulation of peptidyl-threonine phosphorylation 6/896 47/18722 0.0238186659181464 0.141430735190586 APP/BMP7/PLK1/PARD3/CALM2/EIF4G1 6 GO:0006486 protein glycosylation 18/896 226/18722 0.024135534743577 0.142956628865802 GALNT11/RPN2/GXYLT1/FUT8/ALG10B/EXTL2/GCNT2/STT3B/TUSC3/GALNT18/TMTC3/DPY19L1/GFPT1/C1GALT1/TRIP11/RPN1/TMEM165/DDOST 18 GO:0043413 macromolecule glycosylation 18/896 226/18722 0.024135534743577 0.142956628865802 GALNT11/RPN2/GXYLT1/FUT8/ALG10B/EXTL2/GCNT2/STT3B/TUSC3/GALNT18/TMTC3/DPY19L1/GFPT1/C1GALT1/TRIP11/RPN1/TMEM165/DDOST 18 GO:0016331 morphogenesis of embryonic epithelium 13/896 147/18722 0.0242435883980096 0.143418700138907 LRP2/KIF20B/BMP7/LAMA5/SOX4/FZD6/COBL/IRX2/SETD2/SPINT1/SPINT2/ST14/LMO4 13 GO:0001893 maternal placenta development 5/896 35/18722 0.0244777181451327 0.143912101508452 NR2F2/GJA1/CTSV/ASH1L/BSG 5 GO:0015695 organic cation transport 5/896 35/18722 0.0244777181451327 0.143912101508452 SLC29A1/ATP13A3/SLC44A2/SLC38A2/SLC44A1 5 GO:0032232 negative regulation of actin filament bundle assembly 5/896 35/18722 0.0244777181451327 0.143912101508452 STMN1/MET/PPP1R9A/TACSTD2/PPFIA1 5 GO:0035633 maintenance of blood-brain barrier 5/896 35/18722 0.0244777181451327 0.143912101508452 LAMC1/ITGB1/GJA1/VCL/LSR 5 GO:0039694 viral RNA genome replication 5/896 35/18722 0.0244777181451327 0.143912101508452 TOP2A/ROCK2/TRIM28/EEA1/FMR1 5 GO:0072175 epithelial tube formation 12/896 132/18722 0.024549178718633 0.144154709966487 LRP2/KIF20B/BMP7/SOX4/FZD6/COBL/IRX2/SETD2/SPINT1/SPINT2/ST14/LMO4 12 GO:0001843 neural tube closure 9/896 88/18722 0.0247436215302026 0.144860697939102 LRP2/KIF20B/FZD6/COBL/SETD2/SPINT1/SPINT2/ST14/LMO4 9 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 8/896 74/18722 0.0247834120797285 0.144860697939102 PARP1/BRCA1/YAP1/SKP2/SMARCA4/CNOT1/CALR/UFL1 8 GO:0048844 artery morphogenesis 8/896 74/18722 0.0247834120797285 0.144860697939102 LRP2/NRP1/GJA5/PKD2/SOX4/NF1/LRP1/RBPJ 8 GO:0043543 protein acylation 19/896 243/18722 0.0247907813607554 0.144860697939102 BRCA2/BRCA1/CHEK1/HAT1/CEP295/ESCO2/SOX4/CTCF/YEATS4/BRD7/BRD8/SET/USP22/ZDHHC12/SMC5/ZNF451/HDAC2/NCOA3/EID1 19 GO:0072331 signal transduction by p53 class mediator 14/896 163/18722 0.0248586285986601 0.145079575709051 GTSE1/BRCA2/AURKA/PERP/AURKB/CHEK1/MSH2/FOXM1/SOX4/TRIM24/USP10/HINT1/TMEM109/ATRX 14 GO:0050773 regulation of dendrite development 10/896 103/18722 0.025641053683346 0.149463236000359 CDC20/EZH2/BMP7/YWHAH/COBL/VLDLR/NEDD4/CAMSAP2/ID1/IQGAP1 10 GO:0110053 regulation of actin filament organization 21/896 277/18722 0.0256749749341841 0.149478451629018 STMN1/MET/IQGAP2/NRP1/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/ROCK2/PPP1R9A/RDX/MYO1C/ID1/ADD3/TACSTD2/LIMA1/PPFIA1/TRIOBP/RASA1 21 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 4/896 24/18722 0.0257835513526683 0.149563395088261 TYMS/DUT/DTYMK/UNG 4 GO:0051570 regulation of histone H3-K9 methylation 4/896 24/18722 0.0257835513526683 0.149563395088261 BRCA1/RIF1/DNMT1/ATRX 4 GO:1901984 negative regulation of protein acetylation 4/896 24/18722 0.0257835513526683 0.149563395088261 BRCA1/SET/ZNF451/HDAC2 4 GO:0045446 endothelial cell differentiation 11/896 118/18722 0.0259563963430531 0.150383296288514 MET/NRP1/NR2F2/FSTL1/APOLD1/ROCK2/MARVELD2/RDX/VCL/ID1/RBPJ 11 GO:0048146 positive regulation of fibroblast proliferation 6/896 48/18722 0.0261570861716456 0.151333486801383 CCNB1/CCNA2/PRKDC/CDC6/CDK6/DHX9 6 GO:0030111 regulation of Wnt signaling pathway 24/896 328/18722 0.0261837997691543 0.151333486801383 ASPM/EGFR/LGR5/APP/WLS/RNF43/TPBG/KANK1/SOX4/ZNRF3/FZD6/FERMT1/YAP1/LGR4/HMGXB4/G3BP1/SMARCA4/TBL1X/CTNND1/MACF1/LRP1/USP47/RBPJ/TLE4 24 GO:0060606 tube closure 9/896 89/18722 0.0264038441755762 0.152242549392607 LRP2/KIF20B/FZD6/COBL/SETD2/SPINT1/SPINT2/ST14/LMO4 9 GO:0045664 regulation of neuron differentiation 16/896 196/18722 0.0264048661284204 0.152242549392607 ASPM/ECT2/APP/BMP7/ESRP1/CDK5RAP2/YWHAH/SLC6A4/PBX1/ZFHX3/NRCAM/NREP/CALR/TUG1/EIF4G1/ETV5 16 GO:0006287 base-excision repair, gap-filling 3/896 14/18722 0.0267752445879332 0.152718061723767 PCNA/FEN1/LIG1 3 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 3/896 14/18722 0.0267752445879332 0.152718061723767 KANK1/FBLN1/TACSTD2 3 GO:0031054 pre-miRNA processing 3/896 14/18722 0.0267752445879332 0.152718061723767 LIN28B/AGO2/DICER1 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/896 14/18722 0.0267752445879332 0.152718061723767 GJA1/GPAA1/HSPA5 3 GO:0042921 glucocorticoid receptor signaling pathway 3/896 14/18722 0.0267752445879332 0.152718061723767 YWHAH/NEDD4/CALR 3 GO:0060576 intestinal epithelial cell development 3/896 14/18722 0.0267752445879332 0.152718061723767 TYMS/KLF5/YAP1 3 GO:0070141 response to UV-A 3/896 14/18722 0.0267752445879332 0.152718061723767 EGFR/MME/CCND1 3 GO:0071481 cellular response to X-ray 3/896 14/18722 0.0267752445879332 0.152718061723767 NUCKS1/XRCC5/XRCC6 3 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 3/896 14/18722 0.0267752445879332 0.152718061723767 KANK1/FBLN1/TACSTD2 3 GO:0042552 myelination 12/896 134/18722 0.0272132659130951 0.15503118313737 DAG1/ITGB4/PARD3/KIF14/DLG1/MAL2/NF1/DICER1/DEGS1/AFG3L2/HEXB/EPB41L3 12 GO:0045738 negative regulation of DNA repair 5/896 36/18722 0.0273416515938983 0.155361916820121 RIF1/POLQ/RMI2/FANCB/PARPBP 5 GO:0060251 regulation of glial cell proliferation 5/896 36/18722 0.0273416515938983 0.155361916820121 EGFR/DICER1/ETV5/UFL1/IDH2 5 GO:0051651 maintenance of location in cell 17/896 213/18722 0.0273689509940766 0.155361916820121 ASPM/HSP90B1/MCOLN3/BARD1/GJA1/ARHGAP21/GPSM2/ANK3/PKD2/CALM2/VPS13A/GPAA1/TAF3/HNRNPU/HSPA5/AKAP9/CALR 17 GO:0060675 ureteric bud morphogenesis 7/896 62/18722 0.0280877480902896 0.159252861500051 LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 7 GO:0002028 regulation of sodium ion transport 9/896 90/18722 0.0281412009591185 0.159366658812374 ATP1A1/ANK3/DLG1/YWHAH/UTRN/AHCYL1/NEDD4/KIF5B/ATP1B3 9 GO:0009123 nucleoside monophosphate metabolic process 8/896 76/18722 0.0285555237110041 0.160872611125082 TYMS/DUT/TK1/DTYMK/GMPS/DLG1/PPAT/PAICS 8 GO:0071426 ribonucleoprotein complex export from nucleus 8/896 76/18722 0.0285555237110041 0.160872611125082 XPO1/NUP155/NUP107/TPR/HNRNPA2B1/SETD2/RAN/PABPN1 8 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 6/896 49/18722 0.0286430078458986 0.160872611125082 RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 6 GO:0002208 somatic diversification of immunoglobulins involved in immune response 6/896 49/18722 0.0286430078458986 0.160872611125082 RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 6 GO:0009994 oocyte differentiation 6/896 49/18722 0.0286430078458986 0.160872611125082 CCNB1/BRCA2/AURKA/LGR5/FBXO5/ZFX 6 GO:0045190 isotype switching 6/896 49/18722 0.0286430078458986 0.160872611125082 RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 6 GO:0051445 regulation of meiotic cell cycle 6/896 49/18722 0.0286430078458986 0.160872611125082 ASPM/CDC20/RAD51AP1/TTK/FBXO5/CALR 6 GO:0032469 endoplasmic reticulum calcium ion homeostasis 4/896 25/18722 0.0295653674622718 0.165081946508638 APP/ATP2A2/CCDC47/TGM2 4 GO:0060706 cell differentiation involved in embryonic placenta development 4/896 25/18722 0.0295653674622718 0.165081946508638 NR2F2/FZD5/SPINT2/ST14 4 GO:0061436 establishment of skin barrier 4/896 25/18722 0.0295653674622718 0.165081946508638 STMN1/MET/LSR/CLDN4 4 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 4/896 25/18722 0.0295653674622718 0.165081946508638 GJA5/GJA1/ATP1A1/CALM2 4 GO:1903959 regulation of anion transmembrane transport 4/896 25/18722 0.0295653674622718 0.165081946508638 TCAF1/ITGB1/ARL6IP1/GOPC 4 GO:0007272 ensheathment of neurons 12/896 136/18722 0.0300815500359108 0.167376829686991 DAG1/ITGB4/PARD3/KIF14/DLG1/MAL2/NF1/DICER1/DEGS1/AFG3L2/HEXB/EPB41L3 12 GO:0008366 axon ensheathment 12/896 136/18722 0.0300815500359108 0.167376829686991 DAG1/ITGB4/PARD3/KIF14/DLG1/MAL2/NF1/DICER1/DEGS1/AFG3L2/HEXB/EPB41L3 12 GO:0043401 steroid hormone mediated signaling pathway 12/896 136/18722 0.0300815500359108 0.167376829686991 BMP7/PARP1/BRCA1/YWHAH/YAP1/SKP2/NEDD4/SMARCA4/CNOT1/CALR/UFL1/DDX17 12 GO:0072171 mesonephric tubule morphogenesis 7/896 63/18722 0.0303433961998201 0.167817801072882 LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 7 GO:2000242 negative regulation of reproductive process 7/896 63/18722 0.0303433961998201 0.167817801072882 BMP7/TTK/FBXO5/GJA1/PRDX4/CALR/SERPINF1 7 GO:0031112 positive regulation of microtubule polymerization or depolymerization 5/896 37/18722 0.030409946450255 0.167817801072882 MET/CKAP5/CDK5RAP2/CLIP1/AKAP9 5 GO:0048846 axon extension involved in axon guidance 5/896 37/18722 0.030409946450255 0.167817801072882 NRP2/NRP1/SEMA6D/SEMA6A/RYK 5 GO:0051567 histone H3-K9 methylation 5/896 37/18722 0.030409946450255 0.167817801072882 BRCA1/RIF1/DNMT1/ASH1L/ATRX 5 GO:1902284 neuron projection extension involved in neuron projection guidance 5/896 37/18722 0.030409946450255 0.167817801072882 NRP2/NRP1/SEMA6D/SEMA6A/RYK 5 GO:0001704 formation of primary germ layer 11/896 121/18722 0.0305028210156658 0.167817801072882 LAMB1/WLS/BMP7/ITGAV/ITGB1/ITGB4/GJA1/COL4A2/COL5A2/ITGB5/SETD2 11 GO:0043244 regulation of protein-containing complex disassembly 11/896 121/18722 0.0305028210156658 0.167817801072882 TPX2/CKAP2/SPTBN1/IGF1R/EPS8/SVIL/RDX/CAMSAP2/ADD3/LIMA1/TRIOBP 11 GO:0001824 blastocyst development 10/896 106/18722 0.0305210044350626 0.167817801072882 NASP/BRCA2/RRM2/CHEK1/ASF1B/NCAPG2/NEK2/YAP1/CNOT1/RTN4 10 GO:1905477 positive regulation of protein localization to membrane 10/896 106/18722 0.0305210044350626 0.167817801072882 EGFR/TCAF1/ITGB1/SPTBN1/ANK3/DLG1/SLC5A3/MYO1C/KIF5B/LRP1 10 GO:0007492 endoderm development 8/896 77/18722 0.0305826323697962 0.167817801072882 LAMB1/LAMC1/ITGAV/COL4A2/COL5A2/ITGB5/SETD2/BPTF 8 GO:0071166 ribonucleoprotein complex localization 8/896 77/18722 0.0305826323697962 0.167817801072882 XPO1/NUP155/NUP107/TPR/HNRNPA2B1/SETD2/RAN/PABPN1 8 GO:0050673 epithelial cell proliferation 30/896 437/18722 0.030634721940496 0.167910634378792 HMGB2/HMGB1/BRCA2/LAMB1/PRKDC/EGFR/NRP2/LGR5/LAMC1/SUZ12/NRP1/NR2F2/GJA1/MARVELD3/NFIB/DLG1/CCND1/NF1/FERMT1/YAP1/LGR4/PTPRM/CDK6/ID1/TGFBR3/PURA/MAGED1/SERPINF1/HMGN1/RTN4 30 GO:0016573 histone acetylation 13/896 152/18722 0.030783382299565 0.168531957681334 BRCA2/BRCA1/CHEK1/HAT1/CTCF/YEATS4/BRD7/BRD8/SET/USP22/ZNF451/NCOA3/EID1 13 GO:0071902 positive regulation of protein serine/threonine kinase activity 16/896 200/18722 0.0310577701659024 0.169839398364282 CCNB1/CKS2/EGFR/CKS1B/EZH2/DBF4/CDC6/PKD2/CCND1/FZD5/CALM2/IQGAP1/MAGED1/CD24/ERP29/HSP90AB1 16 GO:0000387 spliceosomal snRNP assembly 6/896 50/18722 0.0312794714218065 0.170660796077376 SRSF10/SNRPD1/LSM4/PRPF8/LSM2/SNRPG 6 GO:0043268 positive regulation of potassium ion transport 6/896 50/18722 0.0312794714218065 0.170660796077376 ALG10B/DLG1/AKAP9/KIF5B/ATP1B3/ANO6 6 GO:0009101 glycoprotein biosynthetic process 23/896 317/18722 0.0315607631769525 0.171791284106571 GALNT11/RPN2/GXYLT1/HS6ST2/PAWR/FUT8/ALG10B/EXTL2/GCNT2/AGO2/STT3B/TUSC3/GALNT18/TMTC3/CHST14/DPY19L1/CHPF/GFPT1/C1GALT1/TRIP11/RPN1/TMEM165/DDOST 23 GO:0006986 response to unfolded protein 12/896 137/18722 0.0315946266119752 0.171791284106571 HSP90AA1/CCND1/STT3B/TM7SF3/HSPA5/HSPD1/UBXN4/SERPINH1/HSPA9/UFL1/HSPA8/HSP90AB1 12 GO:0007266 Rho protein signal transduction 12/896 137/18722 0.0315946266119752 0.171791284106571 STMN1/MET/HACD3/ADGRG1/ITGB1/NRP1/KANK1/EPS8/ROCK2/ARHGAP5/NET1/CTNNAL1 12 GO:0031058 positive regulation of histone modification 9/896 92/18722 0.0318536031146449 0.173002390522542 CCNB1/BRCA1/RIF1/MTF2/DNMT1/BRD7/PAXBP1/FMR1/BRD4 9 GO:0036503 ERAD pathway 10/896 107/18722 0.0322841018773494 0.173285148124469 HSP90B1/STT3B/CCDC47/UBE4B/HSPA5/CANX/CALR/UBE2G2/UBXN4/USP14 10 GO:0010452 histone H3-K36 methylation 3/896 15/18722 0.0323049396377833 0.173285148124469 SETD2/ASH1L/BRD4 3 GO:0031958 corticosteroid receptor signaling pathway 3/896 15/18722 0.0323049396377833 0.173285148124469 YWHAH/NEDD4/CALR 3 GO:0033599 regulation of mammary gland epithelial cell proliferation 3/896 15/18722 0.0323049396377833 0.173285148124469 BRCA2/CCND1/RTN4 3 GO:0045176 apical protein localization 3/896 15/18722 0.0323049396377833 0.173285148124469 RDX/DLG5/GOPC 3 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 3/896 15/18722 0.0323049396377833 0.173285148124469 DLGAP5/CDT1/ANAPC5 3 GO:0051290 protein heterotetramerization 3/896 15/18722 0.0323049396377833 0.173285148124469 RRM1/RRM2/PKD2 3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/896 15/18722 0.0323049396377833 0.173285148124469 AGO2/TNRC6A/CNOT1 3 GO:0071474 cellular hyperosmotic response 3/896 15/18722 0.0323049396377833 0.173285148124469 SLC2A1/XRCC5/XRCC6 3 GO:1901970 positive regulation of mitotic sister chromatid separation 3/896 15/18722 0.0323049396377833 0.173285148124469 DLGAP5/CDT1/ANAPC5 3 GO:1905146 lysosomal protein catabolic process 3/896 15/18722 0.0323049396377833 0.173285148124469 LRP2/VPS13A/LRP1 3 GO:0072659 protein localization to plasma membrane 21/896 284/18722 0.0324739592245029 0.17399627535104 CDH1/EGFR/ITGB1/LAMA5/SPTBN1/TPBG/ANK3/EMP2/DLG1/ROCK2/RDX/GOLGA4/MACF1/GOPC/KIF5B/EPB41L3/ATP1B3/LRP1/PPFIA1/CLTC/BSG 21 GO:0009100 glycoprotein metabolic process 27/896 387/18722 0.0326436397998129 0.174709345744738 GALNT11/RPN2/GANAB/GXYLT1/HS6ST2/PAWR/FUT8/ALG10B/EXTL2/GCNT2/AGO2/STT3B/TUSC3/GALNT18/TMTC3/CHST14/DPY19L1/MANBA/CHPF/GFPT1/C1GALT1/TRIP11/PRKCSH/RPN1/TMEM165/DDOST/CTSL 27 GO:0001556 oocyte maturation 4/896 26/18722 0.0336578589552853 0.179084055054577 CCNB1/BRCA2/AURKA/FBXO5 4 GO:0046697 decidualization 4/896 26/18722 0.0336578589552853 0.179084055054577 GJA1/CTSV/ASH1L/BSG 4 GO:0048843 negative regulation of axon extension involved in axon guidance 4/896 26/18722 0.0336578589552853 0.179084055054577 NRP1/SEMA6D/SEMA6A/RYK 4 GO:0097066 response to thyroid hormone 4/896 26/18722 0.0336578589552853 0.179084055054577 GCLM/RDX/BRD8/CTSL 4 GO:1904353 regulation of telomere capping 4/896 26/18722 0.0336578589552853 0.179084055054577 AURKB/NEK2/HNRNPD/RAD50 4 GO:0071392 cellular response to estradiol stimulus 5/896 38/18722 0.0336861083868895 0.179084055054577 CCNA2/EGFR/KIF18A/HNRNPD/NCOA3 5 GO:0071482 cellular response to light stimulus 11/896 123/18722 0.033832810357646 0.179663889485431 PCNA/MME/PBK/PARP1/AURKB/CHEK1/POLD3/NEDD4/FMR1/USP47/DDB1 11 GO:0014009 glial cell proliferation 6/896 51/18722 0.0340692454927145 0.180517844597357 EGFR/SOX4/DICER1/ETV5/UFL1/IDH2 6 GO:0060043 regulation of cardiac muscle cell proliferation 6/896 51/18722 0.0340692454927145 0.180517844597357 CCNB1/CDK1/GJA1/YAP1/TGFBR3/RBPJ 6 GO:0016579 protein deubiquitination 12/896 139/18722 0.0347831885477161 0.18409638816718 CDK1/USP1/USP48/USP22/ASXL1/USP53/USP10/USP27X/USP9X/USP14/USP47/PSMD14 12 GO:0010970 transport along microtubule 13/896 155/18722 0.0352733909667557 0.18627784123373 APP/KIF4A/ARHGAP21/DST/PCM1/SFPQ/LRPPRC/HNRNPU/DYNC1H1/KIF5B/PURA/HSPB11/HSPA8 13 GO:0034614 cellular response to reactive oxygen species 13/896 155/18722 0.0352733909667557 0.18627784123373 CDK1/PCNA/MET/EGFR/ECT2/EZH2/BMP7/DHFR/PAWR/PKD2/NET1/PLEKHA1/HDAC2 13 GO:0097305 response to alcohol 19/896 253/18722 0.0354169954943009 0.186829543082644 TYMS/CDK1/CDH1/GGH/ATP2B1/DAG1/PARP1/BRCA1/RAD51/EPS8/BLM/CCND1/HNRNPD/DNMT3A/TGFBR3/LARP1/HDAC2/GLB1/PSMD14 19 GO:0001503 ossification 28/896 408/18722 0.0359246452886576 0.189298296476878 FBN2/EGFR/ATP2B1/RRBP1/BMP7/FBXO5/LRP5/FIGNL1/CRIM1/PBX1/NF1/SLC26A2/YAP1/LGR4/RBMX/COL5A2/SUCO/CDK6/DHX9/CCDC47/PLXNB1/HNRNPU/ANKH/SYNCRIP/ANO6/RBPJ/UFL1/CLTC 28 GO:0031103 axon regeneration 6/896 52/18722 0.0370148197854394 0.194520694354484 DAG1/DHFR/MTR/NREP/STK24/LRP1 6 GO:0035196 production of miRNAs involved in gene silencing by miRNA 6/896 52/18722 0.0370148197854394 0.194520694354484 EGFR/LIN28B/AGO2/DICER1/HNRNPA2B1/PUM1 6 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 17/896 221/18722 0.0370379788789749 0.194520694354484 AURKA/PBK/CDC20/XPO1/PLK1/NUDT15/SMARCC1/TMTC3/CDK2/FBXO22/RNF217/FMR1/USP14/UFL1/PSMD14/RAD23B/HSP90AB1 17 GO:0016233 telomere capping 5/896 39/18722 0.037173087612374 0.194990120480581 PRKDC/AURKB/NEK2/HNRNPD/RAD50 5 GO:0001570 vasculogenesis 8/896 80/18722 0.0372498931458504 0.194990120480581 ITGAV/AMOT/ITGB8/EMP2/YAP1/SETD2/TGFBR3/RASA1 8 GO:0048145 regulation of fibroblast proliferation 8/896 80/18722 0.0372498931458504 0.194990120480581 CCNB1/CCNA2/PRKDC/CDC6/PAWR/NF1/CDK6/DHX9 8 GO:0051893 regulation of focal adhesion assembly 7/896 66/18722 0.0378306334930419 0.197301643409056 NRP1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 7 GO:0090109 regulation of cell-substrate junction assembly 7/896 66/18722 0.0378306334930419 0.197301643409056 NRP1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 7 GO:0006942 regulation of striated muscle contraction 9/896 95/18722 0.0380384355652934 0.197301643409056 DSP/DSG2/GJA5/ATP1A1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 9 GO:0030516 regulation of axon extension 9/896 95/18722 0.0380384355652934 0.197301643409056 NRP1/SEMA6D/SEMA6A/NRCAM/RYK/GOLGA4/MACF1/LRP1/RTN4 9 GO:0036473 cell death in response to oxidative stress 9/896 95/18722 0.0380384355652934 0.197301643409056 MET/PARP1/PAWR/MELK/SFPQ/P4HB/OXR1/STK24/NONO 9 GO:0018126 protein hydroxylation 4/896 27/18722 0.0380634297402055 0.197301643409056 ASPH/PLOD2/P4HB/PRDX4 4 GO:0032786 positive regulation of DNA-templated transcription, elongation 4/896 27/18722 0.0380634297402055 0.197301643409056 SUPT16H/TCERG1/BRD4/HMGN1 4 GO:0033561 regulation of water loss via skin 4/896 27/18722 0.0380634297402055 0.197301643409056 STMN1/MET/LSR/CLDN4 4 GO:0034698 response to gonadotropin 4/896 27/18722 0.0380634297402055 0.197301643409056 CCNA2/CTSV/GCLM/TGFBR3 4 GO:0016571 histone methylation 12/896 141/18722 0.0381940791692083 0.19755478881764 EZH2/BRCA1/RIF1/SUZ12/MTF2/DNMT1/CTCF/SETD2/PAXBP1/ASH1L/BRD4/ATRX 12 GO:0001977 renal system process involved in regulation of blood volume 3/896 16/18722 0.0383807804964929 0.19755478881764 GJA5/GJA1/EMP2 3 GO:0006349 regulation of gene expression by genetic imprinting 3/896 16/18722 0.0383807804964929 0.19755478881764 BRCA1/CTCF/DNMT3A 3 GO:0035067 negative regulation of histone acetylation 3/896 16/18722 0.0383807804964929 0.19755478881764 BRCA1/SET/ZNF451 3 GO:1901163 regulation of trophoblast cell migration 3/896 16/18722 0.0383807804964929 0.19755478881764 GJA1/AGO2/CALR 3 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 3/896 16/18722 0.0383807804964929 0.19755478881764 DLGAP5/CDT1/ANAPC5 3 GO:0000302 response to reactive oxygen species 17/896 222/18722 0.0384019363265123 0.19755478881764 CDK1/PCNA/MET/EGFR/ECT2/EZH2/BMP7/DHFR/PAWR/PKD2/NUDT15/NET1/PLEKHA1/HSPD1/STK24/HDAC2/TRA2B 17 GO:0070646 protein modification by small protein removal 13/896 157/18722 0.0385156038933129 0.197926257251535 CDK1/USP1/USP48/USP22/ASXL1/USP53/USP10/HINT1/USP27X/USP9X/USP14/USP47/PSMD14 13 GO:0008544 epidermis development 23/896 324/18722 0.0389666375904172 0.200028739630808 DSP/EGFR/LGR5/EZH2/LAMA5/MCOLN3/SVEP1/ESRP1/EXPH5/TFDP1/ATP2A2/FZD6/ROCK2/FERMT1/YAP1/LGR4/PALLD/STS/ST14/HDAC2/RBPJ/NCOA3/TRIOBP 23 GO:0001666 response to hypoxia 22/896 307/18722 0.0391842083038517 0.20092954934757 CCNB1/CCNA2/HP1BP3/HSP90B1/BMP7/SLC29A1/DPP4/PLOD2/APOLD1/SLC6A4/NF1/ROCK2/DNMT3A/PDLIM1/P4HB/TGFBR3/NPEPPS/HSPD1/HILPDA/SLC2A1/RBPJ/CD24 22 GO:0001942 hair follicle development 8/896 81/18722 0.0396730946374425 0.202334530398515 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 8/896 81/18722 0.0396730946374425 0.202334530398515 FBN2/FBN1/LTBP1/GLG1/PEG10/ZNF451/HSPA5/TGFBR3 8 GO:0048144 fibroblast proliferation 8/896 81/18722 0.0396730946374425 0.202334530398515 CCNB1/CCNA2/PRKDC/CDC6/PAWR/NF1/CDK6/DHX9 8 GO:1903533 regulation of protein targeting 8/896 81/18722 0.0396730946374425 0.202334530398515 TCAF1/LMAN1/ANK3/FZD5/SAE1/MYO1C/NPEPPS/HUWE1 8 GO:0009755 hormone-mediated signaling pathway 15/896 190/18722 0.0397124958071655 0.202334530398515 LGR5/BMP7/PARP1/BRCA1/YWHAH/YAP1/SKP2/LGR4/NEDD4/PRLR/SMARCA4/CNOT1/CALR/UFL1/DDX17 15 GO:0030041 actin filament polymerization 15/896 190/18722 0.0397124958071655 0.202334530398515 DIAPH3/IQGAP2/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/COBL/PPP1R9A/RDX/MYO1C/ADD3/TRIOBP/RASA1 15 GO:0008347 glial cell migration 6/896 53/18722 0.0401183995049596 0.203967240933628 LAMB1/ADGRG1/HEXB/LRP1/IDH2/RTN4 6 GO:0051438 regulation of ubiquitin-protein transferase activity 6/896 53/18722 0.0401183995049596 0.203967240933628 UBE2C/UBE2S/MAD2L1/CDC20/FBXO5/PLK1 6 GO:0070085 glycosylation 18/896 240/18722 0.0402443257426215 0.204301793548483 GALNT11/RPN2/GXYLT1/FUT8/ALG10B/EXTL2/GCNT2/STT3B/TUSC3/GALNT18/TMTC3/DPY19L1/GFPT1/C1GALT1/TRIP11/RPN1/TMEM165/DDOST 18 GO:0035282 segmentation 9/896 96/18722 0.0402697921510521 0.204301793548483 PRKDC/NRP2/NRP1/XRCC2/FZD5/COBL/MTF2/IRX2/RBPJ 9 GO:0060485 mesenchyme development 21/896 291/18722 0.0405385608431651 0.205403719678203 HNRNPAB/NRP2/DAG1/EZH2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/PKD2/SEMA6A/GCNT2/ROCK2/YAP1/DLG5/TGFBR3/TRIM28/HDAC2/RBPJ/DDX17/RTN4 21 GO:0009880 embryonic pattern specification 7/896 67/18722 0.0405730430784553 0.205403719678203 NRP2/BMP7/NRP1/PGAP1/MEIS2/FZD5/COBL 7 GO:0009394 2'-deoxyribonucleotide metabolic process 5/896 40/18722 0.0408732780694174 0.20626747304799 TYMS/DUT/DTYMK/NUDT15/UNG 5 GO:0043001 Golgi to plasma membrane protein transport 5/896 40/18722 0.0408732780694174 0.20626747304799 SPTBN1/ANK3/GOLGA4/MACF1/GOPC 5 GO:1901998 toxin transport 5/896 40/18722 0.0408732780694174 0.20626747304799 NRP1/HSPA5/CCT5/CCT2/CCT4 5 GO:0022604 regulation of cell morphogenesis 22/896 309/18722 0.0415986196797216 0.20970624113093 MYH10/PRKDC/DAG1/NRP1/KANK1/PHIP/EPS8/DLG1/RDX/FBLN1/PLXNB1/P4HB/MACF1/CALR/HEXB/EPB41L3/TACSTD2/TRIOBP/RHOBTB3/CLDN4/RASA1/PRPF40A 22 GO:1905475 regulation of protein localization to membrane 14/896 175/18722 0.0417499211198329 0.210246965639328 EGFR/DAG1/TCAF1/ITGB1/SPTBN1/ANK3/DLG1/SLC5A3/MYO1C/GOPC/KIF5B/LRP1/PPFIA1/CLTC 14 GO:0006417 regulation of translation 31/896 468/18722 0.0427085878449307 0.214320124029353 TYMS/PRKDC/APP/HNRNPR/DHFR/TCOF1/SOX4/EXOSC8/TPR/ROCK2/IGF2BP3/AGO2/ILF3/HNRNPD/LRPPRC/DHX9/ASCC3/KHDRBS1/TNRC6A/DCP2/CNOT1/PA2G4/CALR/LARP1/SYNCRIP/PUM1/KHSRP/EIF4G1/FMR1/PURA/NCL 31 GO:0019098 reproductive behavior 4/896 28/18722 0.0427832170506856 0.214320124029353 APP/HEXB/HDAC2/ZFX 4 GO:0032607 interferon-alpha production 4/896 28/18722 0.0427832170506856 0.214320124029353 HMGB1/DHX9/SETD2/HSPD1 4 GO:0032647 regulation of interferon-alpha production 4/896 28/18722 0.0427832170506856 0.214320124029353 HMGB1/DHX9/SETD2/HSPD1 4 GO:1990776 response to angiotensin 4/896 28/18722 0.0427832170506856 0.214320124029353 CDC6/ROCK2/AHCYL1/IQGAP1 4 GO:1903320 regulation of protein modification by small protein conjugation or removal 18/896 242/18722 0.0430636975144872 0.215499048149017 UBE2C/UBE2S/MAD2L1/CDC20/BRCA1/FANCI/HSP90AA1/FBXO5/PLK1/SOX4/SKP2/SAE1/HSPA5/HUWE1/UBA2/UFL1/TRIM44/HSP90AB1 18 GO:0001706 endoderm formation 6/896 54/18722 0.0433819009681333 0.215582596199522 LAMB1/ITGAV/COL4A2/COL5A2/ITGB5/SETD2 6 GO:0031050 dsRNA processing 6/896 54/18722 0.0433819009681333 0.215582596199522 EGFR/LIN28B/AGO2/DICER1/HNRNPA2B1/PUM1 6 GO:0070839 metal ion export 6/896 54/18722 0.0433819009681333 0.215582596199522 ATP2B1/ATP1A1/DLG1/CALM2/ATP1B3/ANO6 6 GO:0070918 production of small RNA involved in gene silencing by RNA 6/896 54/18722 0.0433819009681333 0.215582596199522 EGFR/LIN28B/AGO2/DICER1/HNRNPA2B1/PUM1 6 GO:0010812 negative regulation of cell-substrate adhesion 7/896 68/18722 0.0434416542823504 0.215582596199522 KANK1/GCNT2/CDKN2A/FBLN1/TACSTD2/LRP1/RASA1 7 GO:0060411 cardiac septum morphogenesis 7/896 68/18722 0.0434416542823504 0.215582596199522 LRP2/NRP2/BMP7/NRP1/SOX4/TGFBR3/RBPJ 7 GO:1901016 regulation of potassium ion transmembrane transporter activity 7/896 68/18722 0.0434416542823504 0.215582596199522 ITGB1/ANK3/ALG10B/DLG1/NEDD4/AKAP9/ATP1B3 7 GO:1902305 regulation of sodium ion transmembrane transport 7/896 68/18722 0.0434416542823504 0.215582596199522 ANK3/DLG1/YWHAH/UTRN/NEDD4/KIF5B/ATP1B3 7 GO:0050678 regulation of epithelial cell proliferation 26/896 381/18722 0.0444636919876705 0.220085408447395 HMGB2/HMGB1/BRCA2/LAMB1/PRKDC/EGFR/NRP2/LAMC1/SUZ12/NRP1/NR2F2/GJA1/MARVELD3/NFIB/DLG1/CCND1/NF1/YAP1/PTPRM/CDK6/ID1/TGFBR3/MAGED1/SERPINF1/HMGN1/RTN4 26 GO:0007379 segment specification 3/896 17/18722 0.0449931098158065 0.220085408447395 COBL/MTF2/IRX2 3 GO:0008340 determination of adult lifespan 3/896 17/18722 0.0449931098158065 0.220085408447395 MSH6/MSH2/TFCP2L1 3 GO:0010224 response to UV-B 3/896 17/18722 0.0449931098158065 0.220085408447395 MME/MSH2/HMGN1 3 GO:0016264 gap junction assembly 3/896 17/18722 0.0449931098158065 0.220085408447395 GJA5/GJA1/CNTNAP2 3 GO:0031445 regulation of heterochromatin assembly 3/896 17/18722 0.0449931098158065 0.220085408447395 TPR/DNMT1/TRIM28 3 GO:0031573 mitotic intra-S DNA damage checkpoint signaling 3/896 17/18722 0.0449931098158065 0.220085408447395 FANCD2/MSH2/MDC1 3 GO:0033151 V(D)J recombination 3/896 17/18722 0.0449931098158065 0.220085408447395 HMGB2/HMGB1/PRKDC 3 GO:0046827 positive regulation of protein export from nucleus 3/896 17/18722 0.0449931098158065 0.220085408447395 TPR/CTDSPL2/ANP32B 3 GO:0090136 epithelial cell-cell adhesion 3/896 17/18722 0.0449931098158065 0.220085408447395 DSP/ITGB5/VCL 3 GO:0090399 replicative senescence 3/896 17/18722 0.0449931098158065 0.220085408447395 MME/CHEK1/CDKN2A 3 GO:0120261 regulation of heterochromatin organization 3/896 17/18722 0.0449931098158065 0.220085408447395 TPR/DNMT1/TRIM28 3 GO:1904355 positive regulation of telomere capping 3/896 17/18722 0.0449931098158065 0.220085408447395 AURKB/NEK2/HNRNPD 3 GO:0070301 cellular response to hydrogen peroxide 9/896 98/18722 0.0449944194898738 0.220085408447395 CDK1/PCNA/MET/ECT2/EZH2/PAWR/NET1/PLEKHA1/HDAC2 9 GO:0031396 regulation of protein ubiquitination 16/896 210/18722 0.0452933690580717 0.221320925161959 UBE2C/UBE2S/MAD2L1/CDC20/BRCA1/FANCI/HSP90AA1/FBXO5/PLK1/SOX4/SKP2/HSPA5/HUWE1/UFL1/TRIM44/HSP90AB1 16 GO:0032535 regulation of cellular component size 26/896 382/18722 0.0456395540720406 0.22274812484959 HP1BP3/IQGAP2/NRP1/SEMA6D/SPTBN1/KANK1/KANK4/EPS8/SVIL/SEMA6A/DLG1/NRCAM/PPP1R9A/RDX/MYO1C/RYK/GOLGA4/MACF1/ADD3/ANO6/LRP1/LIMA1/TRIOBP/RASA1/RTN4/HSP90AB1 26 GO:0043524 negative regulation of neuron apoptotic process 12/896 145/18722 0.0457087500142675 0.22274812484959 NRP1/KIF14/MSH2/XRCC2/GCLM/SET/OXR1/HSPD1/LRP1/NONO/RASA1/HSP90AB1 12 GO:0007411 axon guidance 17/896 227/18722 0.0457720801167674 0.22274812484959 NRP2/APP/DAG1/BMP7/NRP1/SEMA6D/LAMA5/NFIB/SEMA6A/NRCAM/PTPRM/PALLD/PLXNB1/RYK/KIF5B/LRP1/BSG 17 GO:0046777 protein autophosphorylation 17/896 227/18722 0.0457720801167674 0.22274812484959 EGFR/AURKA/AURKB/TTK/IGF1R/VRK1/MELK/NEK2/CALM2/IQGAP1/TRIM24/SLK/TRPM7/TRIM28/RAD50/YES1/STK24 17 GO:0015807 L-amino acid transport 7/896 69/18722 0.0464379326093453 0.224842485067966 ITGB1/SLC38A1/SFXN1/ARL6IP1/SLC38A2/SLC1A5/SLC7A6 7 GO:0034605 cellular response to heat 7/896 69/18722 0.0464379326093453 0.224842485067966 HSP90AA1/TPR/ATP2A2/HSPD1/HDAC2/RBBP7/HSP90AB1 7 GO:0045665 negative regulation of neuron differentiation 7/896 69/18722 0.0464379326093453 0.224842485067966 ASPM/APP/BMP7/CDK5RAP2/SLC6A4/PBX1/CALR 7 GO:1901224 positive regulation of NIK/NF-kappaB signaling 7/896 69/18722 0.0464379326093453 0.224842485067966 HMGB1/EGFR/APP/RTKN2/NFAT5/CALR/TRIM44 7 GO:1904377 positive regulation of protein localization to cell periphery 7/896 69/18722 0.0464379326093453 0.224842485067966 EGFR/ITGB1/SPTBN1/GPSM2/DLG1/KIF5B/LRP1 7 GO:0002244 hematopoietic progenitor cell differentiation 10/896 114/18722 0.0466566331768966 0.225672509408819 TOP2A/PRKDC/DHTKD1/ESCO2/SOX4/ZFAT/HSPA9/PRRC2C/UFL1/XRCC5 10 GO:0001755 neural crest cell migration 6/896 55/18722 0.0468069484866026 0.225941731117331 NRP2/BMP7/NRP1/SEMA6D/LAMA5/SEMA6A 6 GO:0003229 ventricular cardiac muscle tissue development 6/896 55/18722 0.0468069484866026 0.225941731117331 LRP2/DSP/DSG2/TGFBR3/LY6E/RBPJ 6 GO:0097485 neuron projection guidance 17/896 228/18722 0.0473592006942836 0.228376590014656 NRP2/APP/DAG1/BMP7/NRP1/SEMA6D/LAMA5/NFIB/SEMA6A/NRCAM/PTPRM/PALLD/PLXNB1/RYK/KIF5B/LRP1/BSG 17 GO:0006970 response to osmotic stress 8/896 84/18722 0.0475651008232958 0.228676527019551 EGFR/MARVELD3/PKD2/NFAT5/SLC2A1/XRCC5/XRCC6/HSP90AB1 8 GO:0022404 molting cycle process 8/896 84/18722 0.0475651008232958 0.228676527019551 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0022405 hair cycle process 8/896 84/18722 0.0475651008232958 0.228676527019551 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0006656 phosphatidylcholine biosynthetic process 4/896 29/18722 0.0478171451637328 0.22873652405978 CHPT1/SLC44A2/CDS1/SLC44A1 4 GO:0021591 ventricular system development 4/896 29/18722 0.0478171451637328 0.22873652405978 CENPF/SEMA6D/CDK6/ANP32B 4 GO:0070979 protein K11-linked ubiquitination 4/896 29/18722 0.0478171451637328 0.22873652405978 UBE2C/UBE2S/UBE2T/ANAPC5 4 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/896 29/18722 0.0478171451637328 0.22873652405978 PARP1/SFPQ/P4HB/NONO 4 GO:1903902 positive regulation of viral life cycle 4/896 29/18722 0.0478171451637328 0.22873652405978 KPNA2/P4HB/FMR1/DDB1 4 GO:0043523 regulation of neuron apoptotic process 16/896 212/18722 0.0486194667738757 0.232341676054537 PARP1/NRP1/KIF14/MSH2/XRCC2/MYBL2/NF1/GCLM/NAE1/SET/OXR1/HSPD1/LRP1/NONO/RASA1/HSP90AB1 16 GO:0051271 negative regulation of cellular component movement 25/896 367/18722 0.0488488609802774 0.232820816142519 HMGB1/CDH1/DAG1/TCAF1/ADGRG1/DPP4/SEMA6D/NR2F2/GJA1/MARVELD3/KANK1/NF1/ACTN1/PTPRM/DLG5/FBLN1/VCL/SPINT2/TGFBR3/CALR/STK24/TACSTD2/LRP1/SERPINF1/IDH2 25 GO:0019692 deoxyribose phosphate metabolic process 5/896 42/18722 0.0489201030004202 0.232820816142519 TYMS/DUT/DTYMK/NUDT15/UNG 5 GO:0035019 somatic stem cell population maintenance 5/896 42/18722 0.0489201030004202 0.232820816142519 BMP7/LRP5/SOX4/YAP1/RBPJ 5 GO:0045687 positive regulation of glial cell differentiation 5/896 42/18722 0.0489201030004202 0.232820816142519 DAG1/DICER1/SPINT1/HDAC2/RHEB 5 GO:0034968 histone lysine methylation 10/896 115/18722 0.0490123418984565 0.232820816142519 EZH2/BRCA1/RIF1/SUZ12/MTF2/DNMT1/SETD2/ASH1L/BRD4/ATRX 10 GO:0043279 response to alkaloid 10/896 115/18722 0.0490123418984565 0.232820816142519 CCNA2/RAD51/BLM/DNMT3A/DHX15/HSPA5/HSPD1/HDAC2/TGM2/HSP90AB1 10 GO:0060537 muscle tissue development 27/896 403/18722 0.0496576865168912 0.235459130611694 CENPF/CCNB1/LRP2/CDK1/DSP/DSG2/BMP7/ITGB1/NR2F2/GJA5/GJA1/PKD2/SVIL/PARP2/DLG1/NF1/KLF5/YAP1/HNRNPU/FBXO22/TGFBR3/CALR/LY6E/CSRP2/RBPJ/CACYBP/DDX17 27 GO:0006612 protein targeting to membrane 11/896 131/18722 0.0497157108622933 0.235459130611694 TCAF1/PARD3/ANK3/ICMT/RAB3IP/ARL6IP1/MYO1C/TRAM2/ZDHHC12/SEC63/HSPA5 11 GO:0045089 positive regulation of innate immune response 11/896 131/18722 0.0497157108622933 0.235459130611694 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/SFPQ/DHX9/PSPC1/NONO/XRCC5/XRCC6 11 GO:0060840 artery development 9/896 100/18722 0.0500753834148795 0.236927532628974 LRP2/NRP1/GJA5/ADAMTS6/PKD2/SOX4/NF1/LRP1/RBPJ 9 GO:0046622 positive regulation of organ growth 6/896 56/18722 0.0503948724545357 0.237556131786672 CCNB1/CDK1/PARP2/YAP1/TGFBR3/RBPJ 6 GO:0051058 negative regulation of small GTPase mediated signal transduction 6/896 56/18722 0.0503948724545357 0.237556131786672 STMN1/MET/ITGB1/KANK1/CD2AP/RASA1 6 GO:0045069 regulation of viral genome replication 8/896 85/18722 0.0504072814201714 0.237556131786672 TOP2A/HACD3/SRPK1/ILF3/PKN2/TRIM28/LARP1/DDB1 8 GO:0098773 skin epidermis development 8/896 85/18722 0.0504072814201714 0.237556131786672 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0021782 glial cell development 10/896 116/18722 0.0514463691307001 0.241840557717705 EGFR/APP/DAG1/ITGB4/PARD3/SOX4/NF1/DICER1/CDK6/LRP1 10 GO:0050680 negative regulation of epithelial cell proliferation 13/896 164/18722 0.0515190295766455 0.241840557717705 BRCA2/SUZ12/NR2F2/GJA1/MARVELD3/NFIB/DLG1/NF1/PTPRM/CDK6/TGFBR3/MAGED1/SERPINF1 13 GO:0050792 regulation of viral process 13/896 164/18722 0.0515190295766455 0.241840557717705 TOP2A/KPNA2/HACD3/SRPK1/ILF3/PKN2/DHX9/P4HB/TRIM28/LARP1/LY6E/FMR1/DDB1 13 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 13/896 164/18722 0.0515190295766455 0.241840557717705 AURKA/PBK/CDC20/XPO1/PLK1/SMARCC1/CDK2/FBXO22/RNF217/USP14/UFL1/RAD23B/HSP90AB1 13 GO:0071248 cellular response to metal ion 15/896 197/18722 0.0516011948717066 0.24198831465376 CCNB1/CDH1/FUS/EGFR/ECT2/APP/PARP1/ANK3/PKD2/MT2A/IQGAP1/HSPA5/CALR/SERPINF1/CACYBP 15 GO:0051384 response to glucocorticoid 12/896 148/18722 0.051974054924666 0.242558803854739 TYMS/HMGB1/PCNA/EGFR/ATP2B1/AGL/CTSV/CCND1/HNRNPU/HSPD1/GLB1/SERPINF1 12 GO:1903900 regulation of viral life cycle 12/896 148/18722 0.051974054924666 0.242558803854739 TOP2A/KPNA2/HACD3/SRPK1/ILF3/PKN2/P4HB/TRIM28/LARP1/LY6E/FMR1/DDB1 12 GO:0031643 positive regulation of myelination 3/896 18/18722 0.0521293114275161 0.242558803854739 DAG1/PARD3/DICER1 3 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 3/896 18/18722 0.0521293114275161 0.242558803854739 TCOF1/SMARCA4/NCL 3 GO:0046112 nucleobase biosynthetic process 3/896 18/18722 0.0521293114275161 0.242558803854739 GMPS/PPAT/PAICS 3 GO:0071786 endoplasmic reticulum tubular network organization 3/896 18/18722 0.0521293114275161 0.242558803854739 TMEM170A/ARL6IP1/RTN4 3 GO:0072234 metanephric nephron tubule development 3/896 18/18722 0.0521293114275161 0.242558803854739 PKD2/YAP1/LGR4 3 GO:1905820 positive regulation of chromosome separation 3/896 18/18722 0.0521293114275161 0.242558803854739 DLGAP5/CDT1/ANAPC5 3 GO:0045732 positive regulation of protein catabolic process 17/896 231/18722 0.0523540362186107 0.243210426494557 LRP2/AURKA/CDC20/HSP90AA1/BARD1/DTL/GJA1/PLK1/TMTC3/RDX/NEDD4/FBXO22/RNF217/HUWE1/FMR1/LRP1/DDB1 17 GO:0021537 telencephalon development 18/896 248/18722 0.0523712439121082 0.243210426494557 ASPM/LAMB1/EZH2/ADGRG1/ARHGAP11B/TACC3/KIF14/CNTNAP2/NFIB/NF1/CDK6/SLC38A2/RYK/KIF5B/LRP1/SLC2A1/TRA2B/RTN4 18 GO:0003281 ventricular septum development 7/896 71/18722 0.0528184736869385 0.244811061535383 LRP2/GJA5/SOX4/TGFBR3/TRIP11/RBPJ/LMO4 7 GO:0150116 regulation of cell-substrate junction organization 7/896 71/18722 0.0528184736869385 0.244811061535383 NRP1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 7 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 4/896 30/18722 0.0531639835027867 0.245231574423038 APP/BMP7/PLK1/CALM2 4 GO:0060218 hematopoietic stem cell differentiation 4/896 30/18722 0.0531639835027867 0.245231574423038 PRKDC/HSPA9/UFL1/XRCC5 4 GO:0061384 heart trabecula morphogenesis 4/896 30/18722 0.0531639835027867 0.245231574423038 BMP7/ADAMTS1/TGFBR3/RBPJ 4 GO:0140058 neuron projection arborization 4/896 30/18722 0.0531639835027867 0.245231574423038 LRP2/NRP1/TPBG/MACF1 4 GO:0006458 'de novo' protein folding 5/896 43/18722 0.0532687772678446 0.245231574423038 HSPA5/HSPD1/HSPA9/HSPA8/CCT2 5 GO:0014002 astrocyte development 5/896 43/18722 0.0532687772678446 0.245231574423038 EGFR/APP/NF1/CDK6/LRP1 5 GO:0030517 negative regulation of axon extension 5/896 43/18722 0.0532687772678446 0.245231574423038 NRP1/SEMA6D/SEMA6A/RYK/RTN4 5 GO:0035023 regulation of Rho protein signal transduction 8/896 86/18722 0.0533569544514763 0.245400867583187 STMN1/MET/ADGRG1/ITGB1/NRP1/KANK1/EPS8/NET1 8 GO:1903828 negative regulation of cellular protein localization 10/896 117/18722 0.0539594724590514 0.247933129470174 LMAN1/BARD1/CDT1/ROCK2/FERMT1/GOPC/UBE2G2/MAGED1/PPFIA1/CLTC 10 GO:0001654 eye development 25/896 371/18722 0.0541602349629636 0.248256428807087 FBN2/HMGB1/RRM1/EFEMP1/FBN1/ATP2B1/TENM3/BMP7/NRP1/FAT1/LRP5/MEIS2/FREM2/DLG1/FZD5/PBX1/NF1/PTPRM/COL5A2/AHI1/SMARCA4/TUG1/HDAC2/SERPINF1/HMGN1 25 GO:0051592 response to calcium ion 12/896 149/18722 0.0541858397186814 0.248256428807087 FUS/EGFR/ECT2/PKD2/CCND1/CALM2/AHCYL1/HNRNPD/NEDD4/IQGAP1/HSPA5/CACYBP 12 GO:1905039 carboxylic acid transmembrane transport 12/896 149/18722 0.0541858397186814 0.248256428807087 LRP2/ITGB1/SLC38A1/SFXN1/SLC16A1/ARL6IP1/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC2A1/SLC13A3 12 GO:0055021 regulation of cardiac muscle tissue growth 7/896 72/18722 0.0562047818632644 0.257013054229142 CCNB1/CDK1/GJA1/PARP2/YAP1/TGFBR3/RBPJ 7 GO:1903036 positive regulation of response to wounding 7/896 72/18722 0.0562047818632644 0.257013054229142 HMGB1/ITGB1/KANK1/FERMT1/ANO6/LRP1/CLDN4 7 GO:0009410 response to xenobiotic stimulus 30/896 462/18722 0.0562865211703827 0.257140528294169 CENPF/TYMS/CCNB1/CDK1/PCNA/CDH1/GGH/EGFR/RPN2/MCM7/XPO1/RAD51/ATP1A1/SLC6A4/NUDT15/GCLM/PPAT/PTPRM/CYB5B/DNMT3A/VKORC1/HSPA5/CALR/HSPD1/HDAC2/HADHA/USP47/XRCC5/ADIRF/HSP90AB1 30 GO:0048041 focal adhesion assembly 8/896 87/18722 0.0564149859588387 0.257441542584871 NRP1/ACTN1/ROCK2/VCL/IQGAP1/MACF1/SLK/LRP1 8 GO:1903825 organic acid transmembrane transport 12/896 150/18722 0.0564602629003687 0.257441542584871 LRP2/ITGB1/SLC38A1/SFXN1/SLC16A1/ARL6IP1/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC2A1/SLC13A3 12 GO:0051101 regulation of DNA binding 10/896 118/18722 0.0565523498771993 0.257615380070372 HMGB2/HMGB1/PARP1/CDT1/HJURP/NEK2/CALM2/ID1/TRIM28/HDAC2 10 GO:0040013 negative regulation of locomotion 26/896 391/18722 0.0572663598748237 0.260619258381705 HMGB1/CDH1/DAG1/TCAF1/ADGRG1/DPP4/NRP1/SEMA6D/NR2F2/GJA1/MARVELD3/KANK1/SEMA6A/NF1/PTPRM/DLG5/FBLN1/VCL/RYK/SPINT2/CALR/STK24/TACSTD2/LRP1/SERPINF1/IDH2 26 GO:0031331 positive regulation of cellular catabolic process 28/896 427/18722 0.0575754870315864 0.261257029861834 LRP2/HMGB1/AURKA/APP/CDC20/HNRNPR/HSP90AA1/PLK1/EXOSC8/LIN28B/ROCK2/AGO2/TMTC3/RDX/KCNQ1OT1/HNRNPD/FBXO22/TNRC6A/DCP2/CNOT1/RNF217/LARP1/PUM1/KHSRP/FMR1/LRP1/UFL1/SLC25A5 28 GO:0060070 canonical Wnt signaling pathway 21/896 303/18722 0.0576285322211061 0.261257029861834 ASPM/EGFR/LGR5/WLS/TPBG/KANK1/LRP5/SOX4/ZNRF3/FZD5/FZD6/FERMT1/YAP1/LGR4/G3BP1/RYK/TBL1X/CTNND1/USP47/RBPJ/TLE4 21 GO:0008154 actin polymerization or depolymerization 16/896 217/18722 0.0576778096820422 0.261257029861834 DIAPH3/IQGAP2/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/COBL/PPP1R9A/RDX/MYO1C/ADD3/LIMA1/TRIOBP/RASA1 16 GO:0002066 columnar/cuboidal epithelial cell development 5/896 44/18722 0.0578347595904647 0.261257029861834 TYMS/KLF5/YAP1/CDK6/RHEB 5 GO:0097178 ruffle assembly 5/896 44/18722 0.0578347595904647 0.261257029861834 KANK1/EPS8/COBL/RDX/TACSTD2 5 GO:1903214 regulation of protein targeting to mitochondrion 5/896 44/18722 0.0578347595904647 0.261257029861834 LMAN1/FZD5/SAE1/NPEPPS/HUWE1 5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 13/896 167/18722 0.0579169522172675 0.261257029861834 CDH1/DSC3/DSG2/TENM3/CADM1/ITGB1/FAT1/CLSTN1/DSC2/PTPRM/PALLD/PCDH11X/BSG 13 GO:0031960 response to corticosteroid 13/896 167/18722 0.0579169522172675 0.261257029861834 TYMS/HMGB1/PCNA/EGFR/ATP2B1/AGL/PARP1/CTSV/CCND1/HNRNPU/HSPD1/GLB1/SERPINF1 13 GO:0018208 peptidyl-proline modification 6/896 58/18722 0.0580631982998337 0.261257029861834 PPIC/NKTR/P4HB/PRDX4/RANBP2/PPIG 6 GO:0035904 aorta development 6/896 58/18722 0.0580631982998337 0.261257029861834 LRP2/ADAMTS6/PKD2/SOX4/LRP1/RBPJ 6 GO:0043666 regulation of phosphoprotein phosphatase activity 6/896 58/18722 0.0580631982998337 0.261257029861834 HSP90B1/SLC39A10/MASTL/CALM2/ROCK2/HSP90AB1 6 GO:2000736 regulation of stem cell differentiation 6/896 58/18722 0.0580631982998337 0.261257029861834 PRKDC/YAP1/HNRNPU/TACSTD2/HSPA9/OCIAD1 6 GO:0048384 retinoic acid receptor signaling pathway 4/896 31/18722 0.0588214080953135 0.26392237053292 EZH2/ASXL1/CNOT1/CALR 4 GO:0051443 positive regulation of ubiquitin-protein transferase activity 4/896 31/18722 0.0588214080953135 0.26392237053292 UBE2C/UBE2S/CDC20/PLK1 4 GO:0090162 establishment of epithelial cell polarity 4/896 31/18722 0.0588214080953135 0.26392237053292 FAT1/PARD3/FRMD4A/FERMT1 4 GO:0010631 epithelial cell migration 24/896 357/18722 0.0595208317103392 0.264960281074345 HMGB1/ANLN/MET/NRP2/DPP4/ITGB1/NRP1/NR2F2/MARVELD3/AMOT/KANK1/FSTL1/EMP2/NF1/ROCK2/FERMT1/PTPRM/PKN2/ID1/MACF1/CALR/TACSTD2/SERPINF1/RTN4 24 GO:0006144 purine nucleobase metabolic process 3/896 19/18722 0.0597742402004754 0.264960281074345 GMPS/PPAT/PAICS 3 GO:0006491 N-glycan processing 3/896 19/18722 0.0597742402004754 0.264960281074345 GANAB/FUT8/PRKCSH 3 GO:0007039 protein catabolic process in the vacuole 3/896 19/18722 0.0597742402004754 0.264960281074345 LRP2/VPS13A/LRP1 3 GO:0008356 asymmetric cell division 3/896 19/18722 0.0597742402004754 0.264960281074345 ASPM/PARD3/ETV5 3 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 3/896 19/18722 0.0597742402004754 0.264960281074345 GMPS/PPAT/PAICS 3 GO:0030011 maintenance of cell polarity 3/896 19/18722 0.0597742402004754 0.264960281074345 DST/DLG5/PDLIM1 3 GO:0044827 modulation by host of viral genome replication 3/896 19/18722 0.0597742402004754 0.264960281074345 NUCKS1/FMR1/HSPA8 3 GO:0046794 transport of virus 3/896 19/18722 0.0597742402004754 0.264960281074345 KPNA2/FMR1/CTSL 3 GO:0070734 histone H3-K27 methylation 3/896 19/18722 0.0597742402004754 0.264960281074345 EZH2/SUZ12/MTF2 3 GO:0086014 atrial cardiac muscle cell action potential 3/896 19/18722 0.0597742402004754 0.264960281074345 GJA5/GJA1/NUP155 3 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 3/896 19/18722 0.0597742402004754 0.264960281074345 GJA5/GJA1/NUP155 3 GO:0086066 atrial cardiac muscle cell to AV node cell communication 3/896 19/18722 0.0597742402004754 0.264960281074345 GJA5/GJA1/NUP155 3 GO:0150063 visual system development 25/896 375/18722 0.059873786576631 0.265155340553652 FBN2/HMGB1/RRM1/EFEMP1/FBN1/ATP2B1/TENM3/BMP7/NRP1/FAT1/LRP5/MEIS2/FREM2/DLG1/FZD5/PBX1/NF1/PTPRM/COL5A2/AHI1/SMARCA4/TUG1/HDAC2/SERPINF1/HMGN1 25 GO:0036293 response to decreased oxygen levels 22/896 322/18722 0.0600063067020971 0.265495929745886 CCNB1/CCNA2/HP1BP3/HSP90B1/BMP7/SLC29A1/DPP4/PLOD2/APOLD1/SLC6A4/NF1/ROCK2/DNMT3A/PDLIM1/P4HB/TGFBR3/NPEPPS/HSPD1/HILPDA/SLC2A1/RBPJ/CD24 22 GO:0002833 positive regulation of response to biotic stimulus 13/896 168/18722 0.0601634578659703 0.265698749169419 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/SFPQ/DHX9/PSPC1/HSPD1/PUM1/NONO/XRCC5/XRCC6 13 GO:2000241 regulation of reproductive process 13/896 168/18722 0.0601634578659703 0.265698749169419 ASPM/AURKA/CDC20/BMP7/RAD51AP1/TTK/FBXO5/GJA1/AGO2/PRDX4/CALR/HDAC2/SERPINF1 13 GO:0007369 gastrulation 14/896 185/18722 0.0610211442605731 0.269237470147852 LAMB1/DAG1/WLS/BMP7/ITGAV/ITGB1/ITGB4/GJA1/AMOT/COL4A2/LRP5/COL5A2/ITGB5/SETD2 14 GO:0060828 regulation of canonical Wnt signaling pathway 18/896 253/18722 0.0611428222443707 0.269524405586595 ASPM/EGFR/LGR5/WLS/TPBG/KANK1/SOX4/ZNRF3/FZD6/FERMT1/YAP1/LGR4/G3BP1/TBL1X/CTNND1/USP47/RBPJ/TLE4 18 GO:0021915 neural tube development 12/896 152/18722 0.0611990899991348 0.269524405586595 LRP2/KIF20B/BMP7/PKD2/SOX4/FZD6/COBL/SETD2/SPINT1/SPINT2/ST14/LMO4 12 GO:1903076 regulation of protein localization to plasma membrane 9/896 104/18722 0.0613347983445338 0.269873112715949 EGFR/ITGB1/SPTBN1/DLG1/GOPC/KIF5B/LRP1/PPFIA1/CLTC 9 GO:0048738 cardiac muscle tissue development 17/896 236/18722 0.0614788371360925 0.270257797870815 CCNB1/LRP2/CDK1/DSP/DSG2/BMP7/ITGB1/GJA5/GJA1/PARP2/YAP1/HNRNPU/TGFBR3/CALR/LY6E/RBPJ/CACYBP 17 GO:0051897 positive regulation of protein kinase B signaling 10/896 120/18722 0.0619799138000963 0.272182777706515 LRP2/MET/EGFR/HSP90AA1/ITGB1/TPBG/IGF1R/GCNT2/RTN4/HSP90AB1 10 GO:0006406 mRNA export from nucleus 6/896 59/18722 0.0621447900502935 0.272182777706515 NUP155/NUP107/TPR/HNRNPA2B1/SETD2/PABPN1 6 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 6/896 59/18722 0.0621447900502935 0.272182777706515 NUP155/NUP107/TPR/HNRNPA2B1/SETD2/PABPN1 6 GO:0090303 positive regulation of wound healing 6/896 59/18722 0.0621447900502935 0.272182777706515 HMGB1/ITGB1/KANK1/FERMT1/ANO6/CLDN4 6 GO:1901653 cellular response to peptide 24/896 359/18722 0.0625980501205645 0.273001940237405 CCNA2/PRKDC/NUCKS1/FBN1/ATP2B1/APP/PARP1/CDC6/GJA1/KANK1/IGF1R/PHIP/TIMELESS/SOGA1/PPAT/KLF5/ROCK2/SMARCC1/SNX5/AHCYL1/MYO1C/ID1/LRP1/SRSF5 24 GO:0035307 positive regulation of protein dephosphorylation 5/896 45/18722 0.062617747080008 0.273001940237405 SLC39A10/CDCA2/CALM2/ANKLE2/HSP90AB1 5 GO:0048538 thymus development 5/896 45/18722 0.062617747080008 0.273001940237405 PRKDC/CCNB2/PBX1/ASXL1/LMO4 5 GO:0048599 oocyte development 5/896 45/18722 0.062617747080008 0.273001940237405 CCNB1/BRCA2/AURKA/FBXO5/ZFX 5 GO:1904646 cellular response to amyloid-beta 5/896 45/18722 0.062617747080008 0.273001940237405 APP/PARP1/GJA1/IGF1R/LRP1 5 GO:0120032 regulation of plasma membrane bounded cell projection assembly 14/896 186/18722 0.0632306910606526 0.275422736426602 ANLN/NRP1/KANK1/EPS8/CCP110/CEP135/KLF5/YAP1/COBL/PPP1R9A/RDX/ATMIN/FMR1/TACSTD2 14 GO:0003151 outflow tract morphogenesis 7/896 74/18722 0.063373233415726 0.275540816326663 LRP2/NRP2/BMP7/NRP1/GJA5/TGFBR3/RBPJ 7 GO:1903201 regulation of oxidative stress-induced cell death 7/896 74/18722 0.063373233415726 0.275540816326663 MET/PARP1/PAWR/SFPQ/P4HB/OXR1/NONO 7 GO:0090132 epithelium migration 24/896 360/18722 0.0641778155081743 0.27878516036035 HMGB1/ANLN/MET/NRP2/DPP4/ITGB1/NRP1/NR2F2/MARVELD3/AMOT/KANK1/FSTL1/EMP2/NF1/ROCK2/FERMT1/PTPRM/PKN2/ID1/MACF1/CALR/TACSTD2/SERPINF1/RTN4 24 GO:0048872 homeostasis of number of cells 19/896 272/18722 0.0642625792355689 0.278899593882369 HMGB2/HMGB1/PRKDC/CCNB2/EZH2/ADGRG1/FSTL1/NCAPG2/SOX4/LGR4/CDK6/ASXL1/TGFBR3/HSPA9/UFL1/ZFX/OCIAD1/RPS17/SLC25A5 19 GO:0032231 regulation of actin filament bundle assembly 9/896 105/18722 0.0643824063686988 0.279165856497882 STMN1/MET/NRP1/ROCK2/PPP1R9A/RDX/ID1/TACSTD2/PPFIA1 9 GO:0050714 positive regulation of protein secretion 11/896 137/18722 0.0644998968190367 0.279168184418931 MYH10/EGFR/WLS/GJA1/EXPH5/SOX4/FRMD4A/TM7SF3/KIF5B/CD2AP/LRP1 11 GO:0060048 cardiac muscle contraction 11/896 137/18722 0.0644998968190367 0.279168184418931 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/DLG1/CALM2/ATP2A2/DSC2/AKAP9 11 GO:0033687 osteoblast proliferation 4/896 32/18722 0.0647860654743308 0.279521313598092 ITGAV/LRP5/FIGNL1/PLXNB1 4 GO:0048841 regulation of axon extension involved in axon guidance 4/896 32/18722 0.0647860654743308 0.279521313598092 NRP1/SEMA6D/SEMA6A/RYK 4 GO:1903955 positive regulation of protein targeting to mitochondrion 4/896 32/18722 0.0647860654743308 0.279521313598092 FZD5/SAE1/NPEPPS/HUWE1 4 GO:0003206 cardiac chamber morphogenesis 10/896 121/18722 0.0648156879248195 0.279521313598092 LRP2/DSP/NRP2/BMP7/NRP1/ADAMTS1/SOX4/TGFBR3/LY6E/RBPJ 10 GO:0008064 regulation of actin polymerization or depolymerization 14/896 187/18722 0.0654932356521489 0.282188363721443 IQGAP2/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/PPP1R9A/RDX/MYO1C/ADD3/LIMA1/TRIOBP/RASA1 14 GO:0070997 neuron death 24/896 361/18722 0.0657852564311205 0.283190995673732 APP/PARP1/NRP1/DHCR24/KIF14/MSH2/XRCC2/MYBL2/PARP2/CIT/NF1/GCLM/NAE1/SET/USP53/HSPA5/OXR1/HSPD1/EIF4G1/LRP1/NONO/SERPINF1/RASA1/HSP90AB1 24 GO:0008360 regulation of cell shape 12/896 154/18722 0.0661943007868962 0.284149898461499 MYH10/DAG1/PHIP/EPS8/DLG1/RDX/PLXNB1/HEXB/EPB41L3/RHOBTB3/RASA1/PRPF40A 12 GO:0030901 midbrain development 8/896 90/18722 0.0662460906970358 0.284149898461499 WLS/CCDC14/YWHAH/CALM2/FZD6/DLG5/RYK/HSPA5 8 GO:0035304 regulation of protein dephosphorylation 8/896 90/18722 0.0662460906970358 0.284149898461499 HSP90B1/SLC39A10/CDCA2/MASTL/CALM2/ROCK2/ANKLE2/HSP90AB1 8 GO:0048477 oogenesis 8/896 90/18722 0.0662460906970358 0.284149898461499 ASPM/CCNB1/BRCA2/AURKA/LGR5/FBXO5/HEXB/ZFX 8 GO:0031102 neuron projection regeneration 6/896 60/18722 0.066391641793666 0.284263406208934 DAG1/DHFR/MTR/NREP/STK24/LRP1 6 GO:0060038 cardiac muscle cell proliferation 6/896 60/18722 0.066391641793666 0.284263406208934 CCNB1/CDK1/GJA1/YAP1/TGFBR3/RBPJ 6 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 11/896 138/18722 0.0672142423179321 0.286907309865698 UBE2C/UBE2S/CDC20/BRCA1/FANCI/PLK1/SKP2/SAE1/HSPA5/HUWE1/UBA2 11 GO:0030833 regulation of actin filament polymerization 13/896 171/18722 0.0672505662256282 0.286907309865698 IQGAP2/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/PPP1R9A/RDX/MYO1C/ADD3/TRIOBP/RASA1 13 GO:0030038 contractile actin filament bundle assembly 9/896 106/18722 0.0675241859295516 0.286907309865698 STMN1/MET/NRP1/ROCK2/PPP1R9A/ITGB5/PDLIM1/TACSTD2/PPFIA1 9 GO:0043149 stress fiber assembly 9/896 106/18722 0.0675241859295516 0.286907309865698 STMN1/MET/NRP1/ROCK2/PPP1R9A/ITGB5/PDLIM1/TACSTD2/PPFIA1 9 GO:0031057 negative regulation of histone modification 5/896 46/18722 0.0676169304985151 0.286907309865698 BRCA1/MTF2/DNMT1/SET/ZNF451 5 GO:0055010 ventricular cardiac muscle tissue morphogenesis 5/896 46/18722 0.0676169304985151 0.286907309865698 LRP2/DSP/TGFBR3/LY6E/RBPJ 5 GO:0060976 coronary vasculature development 5/896 46/18722 0.0676169304985151 0.286907309865698 LRP2/NRP1/ADAMTS6/SETD2/TGFBR3 5 GO:0030832 regulation of actin filament length 14/896 188/18722 0.0678091123684513 0.286907309865698 IQGAP2/SPTBN1/KANK1/KANK4/EPS8/SVIL/DLG1/PPP1R9A/RDX/MYO1C/ADD3/LIMA1/TRIOBP/RASA1 14 GO:0060491 regulation of cell projection assembly 14/896 188/18722 0.0678091123684513 0.286907309865698 ANLN/NRP1/KANK1/EPS8/CCP110/CEP135/KLF5/YAP1/COBL/PPP1R9A/RDX/ATMIN/FMR1/TACSTD2 14 GO:0001832 blastocyst growth 3/896 20/18722 0.0679106116774693 0.286907309865698 BRCA2/CHEK1/NCAPG2 3 GO:0007097 nuclear migration 3/896 20/18722 0.0679106116774693 0.286907309865698 SYNE2/PCM1/DYNC1H1 3 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 3/896 20/18722 0.0679106116774693 0.286907309865698 PARD3/CALM2/EIF4G1 3 GO:0060252 positive regulation of glial cell proliferation 3/896 20/18722 0.0679106116774693 0.286907309865698 EGFR/ETV5/UFL1 3 GO:0061318 renal filtration cell differentiation 3/896 20/18722 0.0679106116774693 0.286907309865698 ASXL1/IQGAP1/CD24 3 GO:0072112 glomerular visceral epithelial cell differentiation 3/896 20/18722 0.0679106116774693 0.286907309865698 ASXL1/IQGAP1/CD24 3 GO:0048880 sensory system development 25/896 381/18722 0.0692242964531515 0.292198754436203 FBN2/HMGB1/RRM1/EFEMP1/FBN1/ATP2B1/TENM3/BMP7/NRP1/FAT1/LRP5/MEIS2/FREM2/DLG1/FZD5/PBX1/NF1/PTPRM/COL5A2/AHI1/SMARCA4/TUG1/HDAC2/SERPINF1/HMGN1 25 GO:0001657 ureteric bud development 8/896 91/18722 0.0697438076111134 0.294131570261003 BMP7/LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 8 GO:0032259 methylation 24/896 364/18722 0.0707753146318538 0.297109850974863 TYMS/HELLS/EZH2/PARP1/BRCA1/RIF1/SUZ12/ICMT/MIS18A/MTR/ZC3H13/MTF2/DNMT1/CTCF/TARBP1/DNMT3A/SETD2/PAXBP1/MTAP/TRIM28/ASH1L/METTL7A/BRD4/ATRX 24 GO:0036336 dendritic cell migration 4/896 33/18722 0.0710536382220954 0.297109850974863 HMGB1/EPS8/CALR/ANO6 4 GO:0040020 regulation of meiotic nuclear division 4/896 33/18722 0.0710536382220954 0.297109850974863 CDC20/RAD51AP1/FBXO5/CALR 4 GO:0042558 pteridine-containing compound metabolic process 4/896 33/18722 0.0710536382220954 0.297109850974863 TYMS/GGH/DHFR/MTR 4 GO:0071353 cellular response to interleukin-4 4/896 33/18722 0.0710536382220954 0.297109850974863 TUBA1B/MCM2/HSPA5/HSP90AB1 4 GO:0071539 protein localization to centrosome 4/896 33/18722 0.0710536382220954 0.297109850974863 AURKA/CCDC14/PCM1/GOLGB1 4 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 4/896 33/18722 0.0710536382220954 0.297109850974863 KANK1/CCP110/YAP1/TACSTD2 4 GO:0014855 striated muscle cell proliferation 7/896 76/18722 0.0710723606647032 0.297109850974863 CCNB1/CDK1/GJA1/YAP1/PAXBP1/TGFBR3/RBPJ 7 GO:0045685 regulation of glial cell differentiation 7/896 76/18722 0.0710723606647032 0.297109850974863 CDK1/DAG1/NF1/DICER1/SPINT1/HDAC2/RHEB 7 GO:0140115 export across plasma membrane 7/896 76/18722 0.0710723606647032 0.297109850974863 ATP2B1/GJA1/ATP1A1/DLG1/CALM2/ATP1B3/ANO6 7 GO:0070482 response to oxygen levels 23/896 347/18722 0.0723138551473392 0.302035297002097 CCNB1/CCNA2/HP1BP3/HSP90B1/BMP7/SLC29A1/DPP4/PLOD2/APOLD1/SLC6A4/NF1/ROCK2/DNMT3A/PDLIM1/P4HB/TGFBR3/NPEPPS/HSPD1/HDAC2/HILPDA/SLC2A1/RBPJ/CD24 23 GO:0090130 tissue migration 24/896 365/18722 0.0724951093817561 0.302527667996944 HMGB1/ANLN/MET/NRP2/DPP4/ITGB1/NRP1/NR2F2/MARVELD3/AMOT/KANK1/FSTL1/EMP2/NF1/ROCK2/FERMT1/PTPRM/PKN2/ID1/MACF1/CALR/TACSTD2/SERPINF1/RTN4 24 GO:0006998 nuclear envelope organization 5/896 47/18722 0.0728310096152256 0.303134472452561 PLK1/VRK1/NUP155/TMEM170A/ANKLE2 5 GO:0014911 positive regulation of smooth muscle cell migration 5/896 47/18722 0.0728310096152256 0.303134472452561 NRP1/SEMA6D/ADAMTS1/IQGAP1/LRP1 5 GO:0031641 regulation of myelination 5/896 47/18722 0.0728310096152256 0.303134472452561 DAG1/PARD3/KIF14/DLG1/DICER1 5 GO:0072163 mesonephric epithelium development 8/896 92/18722 0.073352398515539 0.304773151012344 BMP7/LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 8 GO:0072164 mesonephric tubule development 8/896 92/18722 0.073352398515539 0.304773151012344 BMP7/LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 8 GO:0022412 cellular process involved in reproduction in multicellular organism 25/896 384/18722 0.0742602906734513 0.308277067543527 TOP2A/HMGB2/ASPM/CCNB1/BRCA2/AURKA/CCNB2/LGR5/SMARCA2/ITGB1/TTK/RAD51C/FBXO5/PLK1/MSH2/KIF18A/FIGNL1/SRPK1/CEP57/DNMT3A/PRDX4/HEXB/ETV5/SPESP1/ZFX 25 GO:0007584 response to nutrient 13/896 174/18722 0.0748664730970489 0.310481163873789 TYMS/EGFR/ATP2B1/AGL/BMP7/HAT1/CCND1/SLC6A4/SRSF2/SLC16A1/GCLM/DNMT3A/TRIM24 13 GO:1901215 negative regulation of neuron death 15/896 208/18722 0.0749213030545883 0.310481163873789 NRP1/KIF14/MSH2/XRCC2/PARP2/GCLM/SET/OXR1/HSPD1/EIF4G1/LRP1/NONO/SERPINF1/RASA1/HSP90AB1 15 GO:0032835 glomerulus development 6/896 62/18722 0.0753803253080869 0.310632142011178 ENPEP/BMP7/LGR4/ASXL1/IQGAP1/CD24 6 GO:0060135 maternal process involved in female pregnancy 6/896 62/18722 0.0753803253080869 0.310632142011178 NR2F2/GJA1/CTSV/PPAT/ASH1L/BSG 6 GO:1903078 positive regulation of protein localization to plasma membrane 6/896 62/18722 0.0753803253080869 0.310632142011178 EGFR/ITGB1/SPTBN1/DLG1/KIF5B/LRP1 6 GO:0022898 regulation of transmembrane transporter activity 19/896 278/18722 0.0760175290394342 0.310632142011178 APP/TCAF1/ITGB1/GJA1/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/AHCYL1/NEDD4/AKAP9/GOPC/KIF5B/FMR1/ATP1B3/AHNAK 19 GO:0007350 blastoderm segmentation 3/896 21/18722 0.0765193546303194 0.310632142011178 NRP2/NRP1/FZD5 3 GO:0007617 mating behavior 3/896 21/18722 0.0765193546303194 0.310632142011178 APP/HEXB/HDAC2 3 GO:0008090 retrograde axonal transport 3/896 21/18722 0.0765193546303194 0.310632142011178 DST/DYNC1H1/KIF5B 3 GO:0009067 aspartate family amino acid biosynthetic process 3/896 21/18722 0.0765193546303194 0.310632142011178 PLOD2/MTR/MTAP 3 GO:0009127 purine nucleoside monophosphate biosynthetic process 3/896 21/18722 0.0765193546303194 0.310632142011178 GMPS/PPAT/PAICS 3 GO:0032288 myelin assembly 3/896 21/18722 0.0765193546303194 0.310632142011178 ITGB4/DICER1/EPB41L3 3 GO:0032516 positive regulation of phosphoprotein phosphatase activity 3/896 21/18722 0.0765193546303194 0.310632142011178 SLC39A10/CALM2/HSP90AB1 3 GO:0033962 P-body assembly 3/896 21/18722 0.0765193546303194 0.310632142011178 DYNC1H1/CNOT1/LSM4 3 GO:0038083 peptidyl-tyrosine autophosphorylation 3/896 21/18722 0.0765193546303194 0.310632142011178 EGFR/IGF1R/IQGAP1 3 GO:0044766 multi-organism transport 3/896 21/18722 0.0765193546303194 0.310632142011178 KPNA2/FMR1/CTSL 3 GO:0046823 negative regulation of nucleocytoplasmic transport 3/896 21/18722 0.0765193546303194 0.310632142011178 BARD1/TPR/FERMT1 3 GO:0048714 positive regulation of oligodendrocyte differentiation 3/896 21/18722 0.0765193546303194 0.310632142011178 DAG1/HDAC2/RHEB 3 GO:0048745 smooth muscle tissue development 3/896 21/18722 0.0765193546303194 0.310632142011178 PKD2/DLG1/NF1 3 GO:0072170 metanephric tubule development 3/896 21/18722 0.0765193546303194 0.310632142011178 PKD2/YAP1/LGR4 3 GO:0072243 metanephric nephron epithelium development 3/896 21/18722 0.0765193546303194 0.310632142011178 PKD2/YAP1/LGR4 3 GO:0072311 glomerular epithelial cell differentiation 3/896 21/18722 0.0765193546303194 0.310632142011178 ASXL1/IQGAP1/CD24 3 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 3/896 21/18722 0.0765193546303194 0.310632142011178 LGR4/TACSTD2/MAGED1 3 GO:1902307 positive regulation of sodium ion transmembrane transport 3/896 21/18722 0.0765193546303194 0.310632142011178 ANK3/KIF5B/ATP1B3 3 GO:1902579 multi-organism localization 3/896 21/18722 0.0765193546303194 0.310632142011178 KPNA2/FMR1/CTSL 3 GO:2000774 positive regulation of cellular senescence 3/896 21/18722 0.0765193546303194 0.310632142011178 PAWR/CDKN2A/HMGA1 3 GO:0033273 response to vitamin 8/896 93/18722 0.0770719987959352 0.312344416173 TYMS/EGFR/ATP2B1/BMP7/CCND1/SRSF2/DNMT3A/TRIM24 8 GO:0097306 cellular response to alcohol 8/896 93/18722 0.0770719987959352 0.312344416173 CDH1/ATP2B1/DAG1/BRCA1/RAD51/BLM/DNMT3A/LARP1 8 GO:0006605 protein targeting 21/896 314/18722 0.0772613521761554 0.31284622161914 TCAF1/HSP90AA1/LMAN1/PARD3/ANK3/ICMT/RAB3IP/FZD5/ARL6IP1/VPS13A/SAE1/MYO1C/NEDD4/TRAM2/ZDHHC12/SEC63/HSPA5/NPEPPS/HUWE1/HSPD1/HSPA8 21 GO:0043266 regulation of potassium ion transport 9/896 109/18722 0.0775179457307202 0.313619214337676 ITGB1/ANK3/ALG10B/DLG1/NEDD4/AKAP9/KIF5B/ATP1B3/ANO6 9 GO:0006111 regulation of gluconeogenesis 5/896 48/18722 0.0782582100156419 0.316346058098793 SLC35B4/SOGA1/PGP/RANBP2/DDB1 5 GO:0002002 regulation of angiotensin levels in blood 2/896 10/18722 0.0797804307012157 0.316508378088027 MME/ENPEP 2 GO:0002003 angiotensin maturation 2/896 10/18722 0.0797804307012157 0.316508378088027 MME/ENPEP 2 GO:0007028 cytoplasm organization 2/896 10/18722 0.0797804307012157 0.316508378088027 TFCP2L1/KIF5B 2 GO:0010992 ubiquitin recycling 2/896 10/18722 0.0797804307012157 0.316508378088027 UBE2C/UBE2S 2 GO:0016139 glycoside catabolic process 2/896 10/18722 0.0797804307012157 0.316508378088027 GUSB/FUCA2 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/896 10/18722 0.0797804307012157 0.316508378088027 P4HB/PRDX4 2 GO:0021562 vestibulocochlear nerve development 2/896 10/18722 0.0797804307012157 0.316508378088027 NRP2/NRP1 2 GO:0021932 hindbrain radial glia guided cell migration 2/896 10/18722 0.0797804307012157 0.316508378088027 ITGB1/RERE 2 GO:0031125 rRNA 3'-end processing 2/896 10/18722 0.0797804307012157 0.316508378088027 EXOSC8/RPS21 2 GO:0032070 regulation of deoxyribonuclease activity 2/896 10/18722 0.0797804307012157 0.316508378088027 HMGB1/PCNA 2 GO:0048755 branching morphogenesis of a nerve 2/896 10/18722 0.0797804307012157 0.316508378088027 RERE/RTN4 2 GO:0051409 response to nitrosative stress 2/896 10/18722 0.0797804307012157 0.316508378088027 GCLM/ADH5 2 GO:0061299 retina vasculature morphogenesis in camera-type eye 2/896 10/18722 0.0797804307012157 0.316508378088027 NRP1/LRP5 2 GO:0072070 loop of Henle development 2/896 10/18722 0.0797804307012157 0.316508378088027 PKD2/IRX2 2 GO:0140059 dendrite arborization 2/896 10/18722 0.0797804307012157 0.316508378088027 NRP1/TPBG 2 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 2/896 10/18722 0.0797804307012157 0.316508378088027 SMARCA4/NCL 2 GO:1902855 regulation of non-motile cilium assembly 2/896 10/18722 0.0797804307012157 0.316508378088027 CEP135/ATMIN 2 GO:1903867 extraembryonic membrane development 2/896 10/18722 0.0797804307012157 0.316508378088027 BMP7/FZD5 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/896 10/18722 0.0797804307012157 0.316508378088027 LRP2/LRP1 2 GO:2000121 regulation of removal of superoxide radicals 2/896 10/18722 0.0797804307012157 0.316508378088027 BMP7/DHFR 2 GO:2000288 positive regulation of myoblast proliferation 2/896 10/18722 0.0797804307012157 0.316508378088027 MEIS2/PAXBP1 2 GO:2000425 regulation of apoptotic cell clearance 2/896 10/18722 0.0797804307012157 0.316508378088027 HMGB1/TGM2 2 GO:0035966 response to topologically incorrect protein 12/896 159/18722 0.0798232273183881 0.316508378088027 HSP90AA1/CCND1/STT3B/TM7SF3/HSPA5/HSPD1/UBXN4/SERPINH1/HSPA9/UFL1/HSPA8/HSP90AB1 12 GO:0045143 homologous chromosome segregation 6/896 63/18722 0.0801210546879045 0.317425655668096 PTTG1/RAD21/PLK1/FANCD2/NDC1/CCNE1 6 GO:0006814 sodium ion transport 17/896 245/18722 0.0805320651060358 0.318789451754739 SLC38A1/SLC20A1/ATP1A1/ANK3/PKD2/DLG1/YWHAH/SLC6A4/UTRN/SLC5A3/AHCYL1/NEDD4/SLC38A2/KIF5B/ATP1B3/ANO6/SLC13A3 17 GO:0061387 regulation of extent of cell growth 9/896 110/18722 0.0810393625750834 0.320531828445276 NRP1/SEMA6D/SEMA6A/NRCAM/RYK/GOLGA4/MACF1/LRP1/RTN4 9 GO:0060420 regulation of heart growth 7/896 79/18722 0.0836173357928845 0.330190388946216 CCNB1/CDK1/GJA1/PARP2/YAP1/TGFBR3/RBPJ 7 GO:0006376 mRNA splice site selection 5/896 49/18722 0.0838963011712945 0.330190388946216 PSIP1/SRSF10/SF1/LUC7L3/SRSF5 5 GO:0034332 adherens junction organization 5/896 49/18722 0.0838963011712945 0.330190388946216 CDH1/DSP/RDX/DLG5/VCL 5 GO:0046580 negative regulation of Ras protein signal transduction 5/896 49/18722 0.0838963011712945 0.330190388946216 STMN1/MET/ITGB1/KANK1/RASA1 5 GO:0051932 synaptic transmission, GABAergic 5/896 49/18722 0.0838963011712945 0.330190388946216 EZH2/TPBG/GABRE/ZDHHC12/KIF5B 5 GO:0070169 positive regulation of biomineral tissue development 5/896 49/18722 0.0838963011712945 0.330190388946216 FBN2/ATP2B1/BMP7/FBXO5/ANO6 5 GO:0071695 anatomical structure maturation 16/896 229/18722 0.0839707841158691 0.330211304257956 TYMS/CCNB1/BRCA2/AURKA/APP/DAG1/FBXO5/KIF14/CNTNAP2/FZD5/NRCAM/FERMT1/RERE/PLXNB1/TFCP2L1/RBPJ 16 GO:0010765 positive regulation of sodium ion transport 4/896 35/18722 0.084475839621684 0.330563654388458 ANK3/AHCYL1/KIF5B/ATP1B3 4 GO:0032205 negative regulation of telomere maintenance 4/896 35/18722 0.084475839621684 0.330563654388458 PARP1/HNRNPU/DCP2/RAD50 4 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 4/896 35/18722 0.084475839621684 0.330563654388458 PBK/SMARCC1/USP14/HSP90AB1 4 GO:0086005 ventricular cardiac muscle cell action potential 4/896 35/18722 0.084475839621684 0.330563654388458 DSP/DSG2/DLG1/DSC2 4 GO:0098801 regulation of renal system process 4/896 35/18722 0.084475839621684 0.330563654388458 GJA5/GJA1/EMP2/SNX5 4 GO:1905508 protein localization to microtubule organizing center 4/896 35/18722 0.084475839621684 0.330563654388458 AURKA/CCDC14/PCM1/GOLGB1 4 GO:0032479 regulation of type I interferon production 8/896 95/18722 0.0848441552983198 0.331190512996058 HMGB2/HMGB1/HSP90AA1/POLA1/G3BP1/DHX9/SETD2/HSPD1 8 GO:0032606 type I interferon production 8/896 95/18722 0.0848441552983198 0.331190512996058 HMGB2/HMGB1/HSP90AA1/POLA1/G3BP1/DHX9/SETD2/HSPD1 8 GO:1901379 regulation of potassium ion transmembrane transport 8/896 95/18722 0.0848441552983198 0.331190512996058 ITGB1/ANK3/ALG10B/DLG1/NEDD4/AKAP9/ATP1B3/ANO6 8 GO:0010975 regulation of neuron projection development 28/896 445/18722 0.0855053684004309 0.331353271044193 ITGA6/TENM3/CDC20/EZH2/BMP7/NRP1/SEMA6D/KANK1/SEMA6A/YWHAH/COBL/VLDLR/PPP1R9A/NEDD4/PLXNB1/RYK/GOLGA4/CAMSAP2/ID1/IQGAP1/MACF1/HSPA5/CAMK2G/STK24/HDAC2/LRP1/SERPINF1/RTN4 28 GO:0007413 axonal fasciculation 3/896 22/18722 0.0855799294506682 0.331353271044193 NRP1/NRCAM/RTN4 3 GO:0016137 glycoside metabolic process 3/896 22/18722 0.0855799294506682 0.331353271044193 GUSB/FUCA2/AKR7A2 3 GO:0031061 negative regulation of histone methylation 3/896 22/18722 0.0855799294506682 0.331353271044193 BRCA1/MTF2/DNMT1 3 GO:0032069 regulation of nuclease activity 3/896 22/18722 0.0855799294506682 0.331353271044193 HMGB2/HMGB1/PCNA 3 GO:0036120 cellular response to platelet-derived growth factor stimulus 3/896 22/18722 0.0855799294506682 0.331353271044193 CCNA2/RDX/YES1 3 GO:0045048 protein insertion into ER membrane 3/896 22/18722 0.0855799294506682 0.331353271044193 CCDC47/TRAM2/EMC1 3 GO:0060343 trabecula formation 3/896 22/18722 0.0855799294506682 0.331353271044193 FBN2/ADAMTS1/TGFBR3 3 GO:0106030 neuron projection fasciculation 3/896 22/18722 0.0855799294506682 0.331353271044193 NRP1/NRCAM/RTN4 3 GO:2000114 regulation of establishment of cell polarity 3/896 22/18722 0.0855799294506682 0.331353271044193 KIF20B/KANK1/ROCK2 3 GO:0007422 peripheral nervous system development 7/896 80/18722 0.088063528923422 0.340417236502362 CDK1/DAG1/ITGB4/PARD3/SLC5A3/NF1/DICER1 7 GO:0071229 cellular response to acid chemical 7/896 80/18722 0.088063528923422 0.340417236502362 IPO5/PKD2/GCLM/DNMT1/COL5A2/HNRNPD/DNMT3A 7 GO:0000956 nuclear-transcribed mRNA catabolic process 9/896 112/18722 0.088367753804395 0.341316874322154 EXOSC8/AGO2/TNRC6A/DCP2/CNOT1/LSM4/RNPS1/THRAP3/PNRC2 9 GO:0001823 mesonephros development 8/896 96/18722 0.0888963701298896 0.342803934571965 BMP7/LAMA5/PKD2/DLG1/PBX1/LGR4/TACSTD2/MAGED1 8 GO:0010769 regulation of cell morphogenesis involved in differentiation 8/896 96/18722 0.0888963701298896 0.342803934571965 PRKDC/NRP1/KANK1/FBLN1/P4HB/CALR/TACSTD2/TRIOBP 8 GO:0060688 regulation of morphogenesis of a branching structure 5/896 50/18722 0.0897426155879043 0.345230658192309 BMP7/LGR4/TACSTD2/MAGED1/RTN4 5 GO:0110151 positive regulation of biomineralization 5/896 50/18722 0.0897426155879043 0.345230658192309 FBN2/ATP2B1/BMP7/FBXO5/ANO6 5 GO:1903747 regulation of establishment of protein localization to mitochondrion 5/896 50/18722 0.0897426155879043 0.345230658192309 LMAN1/FZD5/SAE1/NPEPPS/HUWE1 5 GO:0070936 protein K48-linked ubiquitination 6/896 65/18722 0.0900904835701325 0.346289829761524 UBE2C/UBE2T/SKP2/CUL1/UBE2G2/TRIM44 6 GO:0032412 regulation of ion transmembrane transporter activity 18/896 267/18722 0.0909197901967656 0.34919636234864 APP/TCAF1/ITGB1/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/AHCYL1/NEDD4/AKAP9/GOPC/KIF5B/FMR1/ATP1B3/AHNAK 18 GO:0042542 response to hydrogen peroxide 11/896 146/18722 0.0915676163374208 0.349397318266106 CDK1/PCNA/MET/ECT2/EZH2/PAWR/NET1/PLEKHA1/HSPD1/STK24/HDAC2 11 GO:0009225 nucleotide-sugar metabolic process 4/896 36/18722 0.0916176131251572 0.349397318266106 FUT8/EXTL2/UXS1/GFPT1 4 GO:0070670 response to interleukin-4 4/896 36/18722 0.0916176131251572 0.349397318266106 TUBA1B/MCM2/HSPA5/HSP90AB1 4 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/896 36/18722 0.0916176131251572 0.349397318266106 FZD5/SAE1/NPEPPS/HUWE1 4 GO:0014032 neural crest cell development 7/896 81/18722 0.0926410024369605 0.349397318266106 NRP2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A 7 GO:2001021 negative regulation of response to DNA damage stimulus 7/896 81/18722 0.0926410024369605 0.349397318266106 RIF1/FBXO5/POLQ/RMI2/FANCB/PARPBP/USP47 7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 8/896 97/18722 0.0930589131991459 0.349397318266106 HMGB2/ITGA6/ITGAV/BRCA1/NRP1/PHIP/GCLM/YAP1 8 GO:0090287 regulation of cellular response to growth factor stimulus 20/896 304/18722 0.0940396814570374 0.349397318266106 FBN2/LRP2/FBN1/FSTL1/LTBP1/CRIM1/SEMA6A/CTDSPL2/FERMT1/MYO1C/GLG1/NEDD4/PEG10/TRIM33/ZNF451/HSPA5/TGFBR3/NREP/RBPJ/HSP90AB1 20 GO:0003139 secondary heart field specification 2/896 11/18722 0.0945083156292462 0.349397318266106 LRP2/RBPJ 2 GO:0003174 mitral valve development 2/896 11/18722 0.0945083156292462 0.349397318266106 GJA5/SOX4 2 GO:0006020 inositol metabolic process 2/896 11/18722 0.0945083156292462 0.349397318266106 SLC5A3/ISYNA1 2 GO:0006188 IMP biosynthetic process 2/896 11/18722 0.0945083156292462 0.349397318266106 PPAT/PAICS 2 GO:0009120 deoxyribonucleoside metabolic process 2/896 11/18722 0.0945083156292462 0.349397318266106 TK1/DTYMK 2 GO:0009313 oligosaccharide catabolic process 2/896 11/18722 0.0945083156292462 0.349397318266106 MANBA/HEXB 2 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 2/896 11/18722 0.0945083156292462 0.349397318266106 ATP1A1/ATP1B3 2 GO:0019048 modulation by virus of host process 2/896 11/18722 0.0945083156292462 0.349397318266106 DAG1/ANO6 2 GO:0021561 facial nerve development 2/896 11/18722 0.0945083156292462 0.349397318266106 NRP2/NRP1 2 GO:0021604 cranial nerve structural organization 2/896 11/18722 0.0945083156292462 0.349397318266106 NRP2/NRP1 2 GO:0021610 facial nerve morphogenesis 2/896 11/18722 0.0945083156292462 0.349397318266106 NRP2/NRP1 2 GO:0033197 response to vitamin E 2/896 11/18722 0.0945083156292462 0.349397318266106 CCND1/SRSF2 2 GO:0033690 positive regulation of osteoblast proliferation 2/896 11/18722 0.0945083156292462 0.349397318266106 ITGAV/LRP5 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/896 11/18722 0.0945083156292462 0.349397318266106 HMGB1/RTN4 2 GO:0043589 skin morphogenesis 2/896 11/18722 0.0945083156292462 0.349397318266106 ITGA6/ITGB4 2 GO:0044771 meiotic cell cycle phase transition 2/896 11/18722 0.0945083156292462 0.349397318266106 CCNB2/TTK 2 GO:0045161 neuronal ion channel clustering 2/896 11/18722 0.0945083156292462 0.349397318266106 CNTNAP2/NRCAM 2 GO:0046929 negative regulation of neurotransmitter secretion 2/896 11/18722 0.0945083156292462 0.349397318266106 PPP1R9A/FMR1 2 GO:0048096 chromatin-mediated maintenance of transcription 2/896 11/18722 0.0945083156292462 0.349397318266106 CDCA4/CHEK1 2 GO:0051081 nuclear membrane disassembly 2/896 11/18722 0.0945083156292462 0.349397318266106 PLK1/VRK1 2 GO:0051573 negative regulation of histone H3-K9 methylation 2/896 11/18722 0.0945083156292462 0.349397318266106 BRCA1/DNMT1 2 GO:0051574 positive regulation of histone H3-K9 methylation 2/896 11/18722 0.0945083156292462 0.349397318266106 BRCA1/RIF1 2 GO:0055015 ventricular cardiac muscle cell development 2/896 11/18722 0.0945083156292462 0.349397318266106 CCNB1/CDK1 2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 2/896 11/18722 0.0945083156292462 0.349397318266106 PKD2/CALM2 2 GO:0060837 blood vessel endothelial cell differentiation 2/896 11/18722 0.0945083156292462 0.349397318266106 NRP1/RBPJ 2 GO:0061314 Notch signaling involved in heart development 2/896 11/18722 0.0945083156292462 0.349397318266106 GALNT11/RBPJ 2 GO:0071888 macrophage apoptotic process 2/896 11/18722 0.0945083156292462 0.349397318266106 CDKN2A/CTSL 2 GO:0072697 protein localization to cell cortex 2/896 11/18722 0.0945083156292462 0.349397318266106 PLK1/GPSM2 2 GO:0075733 intracellular transport of virus 2/896 11/18722 0.0945083156292462 0.349397318266106 KPNA2/FMR1 2 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 2/896 11/18722 0.0945083156292462 0.349397318266106 DNMT1/TRIM28 2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 2/896 11/18722 0.0945083156292462 0.349397318266106 SLC35B4/SLC35D1 2 GO:0140042 lipid droplet formation 2/896 11/18722 0.0945083156292462 0.349397318266106 CDS1/SQLE 2 GO:1902065 response to L-glutamate 2/896 11/18722 0.0945083156292462 0.349397318266106 PCNA/UFL1 2 GO:1904181 positive regulation of membrane depolarization 2/896 11/18722 0.0945083156292462 0.349397318266106 PARP1/ANK3 2 GO:1905668 positive regulation of protein localization to endosome 2/896 11/18722 0.0945083156292462 0.349397318266106 ROCK2/RDX 2 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 2/896 11/18722 0.0945083156292462 0.349397318266106 HMGB1/LRP1 2 GO:0006479 protein methylation 13/896 181/18722 0.0947300010154416 0.349397318266106 EZH2/BRCA1/RIF1/SUZ12/ICMT/MTF2/DNMT1/CTCF/SETD2/PAXBP1/ASH1L/BRD4/ATRX 13 GO:0008213 protein alkylation 13/896 181/18722 0.0947300010154416 0.349397318266106 EZH2/BRCA1/RIF1/SUZ12/ICMT/MTF2/DNMT1/CTCF/SETD2/PAXBP1/ASH1L/BRD4/ATRX 13 GO:0009162 deoxyribonucleoside monophosphate metabolic process 3/896 23/18722 0.0950706150874888 0.349397318266106 TYMS/DUT/TK1 3 GO:0021871 forebrain regionalization 3/896 23/18722 0.0950706150874888 0.349397318266106 ADGRG1/PGAP1/TRA2B 3 GO:0030325 adrenal gland development 3/896 23/18722 0.0950706150874888 0.349397318266106 PBX1/NF1/LY6E 3 GO:0036119 response to platelet-derived growth factor 3/896 23/18722 0.0950706150874888 0.349397318266106 CCNA2/RDX/YES1 3 GO:0045724 positive regulation of cilium assembly 3/896 23/18722 0.0950706150874888 0.349397318266106 CCP110/CEP135/ATMIN 3 GO:0051457 maintenance of protein location in nucleus 3/896 23/18722 0.0950706150874888 0.349397318266106 BARD1/TAF3/HNRNPU 3 GO:0060487 lung epithelial cell differentiation 3/896 23/18722 0.0950706150874888 0.349397318266106 NFIB/YAP1/RBPJ 3 GO:0060575 intestinal epithelial cell differentiation 3/896 23/18722 0.0950706150874888 0.349397318266106 TYMS/KLF5/YAP1 3 GO:1902410 mitotic cytokinetic process 3/896 23/18722 0.0950706150874888 0.349397318266106 KIF20B/CEP55/KIF20A 3 GO:2000737 negative regulation of stem cell differentiation 3/896 23/18722 0.0950706150874888 0.349397318266106 YAP1/HNRNPU/HSPA9 3 GO:0045600 positive regulation of fat cell differentiation 6/896 66/18722 0.0953164685778416 0.350031400762012 BMP7/LRP5/CDS1/KLF5/HNRNPU/ADIRF 6 GO:2000146 negative regulation of cell motility 23/896 359/18722 0.0958274107307352 0.351637247370123 HMGB1/CDH1/DAG1/TCAF1/ADGRG1/DPP4/SEMA6D/NR2F2/GJA1/MARVELD3/KANK1/NF1/PTPRM/DLG5/FBLN1/VCL/SPINT2/CALR/STK24/TACSTD2/LRP1/SERPINF1/IDH2 23 GO:0018022 peptidyl-lysine methylation 10/896 131/18722 0.097722174958619 0.358039649464656 EZH2/BRCA1/RIF1/SUZ12/MTF2/DNMT1/SETD2/ASH1L/BRD4/ATRX 10 GO:0046683 response to organophosphorus 10/896 131/18722 0.097722174958619 0.358039649464656 TYMS/HSP90B1/APP/RFC3/PKD2/SLC6A4/HSPA5/AKAP9/HSPD1/BSG 10 GO:0071772 response to BMP 12/896 165/18722 0.0983603782415766 0.359825628908266 LRP2/FBN1/BMP7/FSTL1/CRIM1/CTDSPL2/TRIM33/SPINT1/SPINT2/TGFBR3/USP9X/RBPJ 12 GO:0071773 cellular response to BMP stimulus 12/896 165/18722 0.0983603782415766 0.359825628908266 LRP2/FBN1/BMP7/FSTL1/CRIM1/CTDSPL2/TRIM33/SPINT1/SPINT2/TGFBR3/USP9X/RBPJ 12 GO:0006862 nucleotide transport 4/896 37/18722 0.0990367242372665 0.362022451384924 SLC29A1/GJA1/SLC25A36/SLC25A5 4 GO:0006513 protein monoubiquitination 6/896 67/18722 0.100701067807289 0.367543499779816 UBE2T/DTL/RNF168/HUWE1/CUL1/DDB1 6 GO:0043967 histone H4 acetylation 6/896 67/18722 0.100701067807289 0.367543499779816 BRCA2/BRCA1/HAT1/YEATS4/BRD8/USP22 6 GO:0030514 negative regulation of BMP signaling pathway 5/896 52/18722 0.102047180462704 0.372172069922802 LRP2/FBN1/CRIM1/CTDSPL2/TRIM33 5 GO:0048678 response to axon injury 7/896 83/18722 0.102186227708395 0.372394695480823 CDK1/DAG1/DHFR/MTR/NREP/STK24/LRP1 7 GO:0003148 outflow tract septum morphogenesis 3/896 24/18722 0.104968767049606 0.378776185861541 LRP2/NRP2/NRP1 3 GO:0016486 peptide hormone processing 3/896 24/18722 0.104968767049606 0.378776185861541 MME/ENPEP/CTSL 3 GO:0021801 cerebral cortex radial glia-guided migration 3/896 24/18722 0.104968767049606 0.378776185861541 LAMB1/ADGRG1/RTN4 3 GO:0022030 telencephalon glial cell migration 3/896 24/18722 0.104968767049606 0.378776185861541 LAMB1/ADGRG1/RTN4 3 GO:0030859 polarized epithelial cell differentiation 3/896 24/18722 0.104968767049606 0.378776185861541 FAT1/AHI1/DLG5 3 GO:0036010 protein localization to endosome 3/896 24/18722 0.104968767049606 0.378776185861541 NRP1/ROCK2/RDX 3 GO:0044321 response to leptin 3/896 24/18722 0.104968767049606 0.378776185861541 LRP2/CCNA2/CCND1 3 GO:0051647 nucleus localization 3/896 24/18722 0.104968767049606 0.378776185861541 SYNE2/PCM1/DYNC1H1 3 GO:0060479 lung cell differentiation 3/896 24/18722 0.104968767049606 0.378776185861541 NFIB/YAP1/RBPJ 3 GO:0060561 apoptotic process involved in morphogenesis 3/896 24/18722 0.104968767049606 0.378776185861541 BMP7/LRP5/FZD5 3 GO:0072010 glomerular epithelium development 3/896 24/18722 0.104968767049606 0.378776185861541 ASXL1/IQGAP1/CD24 3 GO:0090343 positive regulation of cell aging 3/896 24/18722 0.104968767049606 0.378776185861541 PAWR/CDKN2A/HMGA1 3 GO:1903077 negative regulation of protein localization to plasma membrane 3/896 24/18722 0.104968767049606 0.378776185861541 GOPC/PPFIA1/CLTC 3 GO:0031334 positive regulation of protein-containing complex assembly 16/896 237/18722 0.105220729090691 0.379398610784712 MET/IQGAP2/HSP90AA1/CDT1/CKAP5/CDK5RAP2/DLG1/SLF2/FERMT1/MYO1C/ICE1/CLIP1/MPP7/AKAP9/EIF4G1/ASAP1 16 GO:0045785 positive regulation of cell adhesion 27/896 437/18722 0.105508642432847 0.380149629414649 HMGB1/ITGA6/DAG1/ADGRG1/BMP7/ITGAV/DPP4/NRP1/ANK3/EMP2/SOX4/GCNT2/UTRN/ZFHX3/CD46/FERMT1/NFAT5/CDK6/CCDC80/IQGAP1/P4HB/CALR/YES1/HSPD1/CD24/TRIOBP/TGM2 27 GO:0110020 regulation of actomyosin structure organization 8/896 100/18722 0.106203204096951 0.381928273163043 STMN1/MET/ECT2/NRP1/ROCK2/PPP1R9A/TACSTD2/PPFIA1 8 GO:0042698 ovulation cycle 6/896 68/18722 0.106242301374219 0.381928273163043 PCNA/EGFR/ADAMTS1/HSPA5/PLEKHA1/SERPINF1 6 GO:0046686 response to cadmium ion 6/896 68/18722 0.106242301374219 0.381928273163043 CDK1/PCNA/EGFR/DTYMK/MT2A/CYB5A 6 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 4/896 38/18722 0.10672503198437 0.382224533153324 BRCA1/SMARCA4/CNOT1/CALR 4 GO:0042491 inner ear auditory receptor cell differentiation 4/896 38/18722 0.10672503198437 0.382224533153324 MCOLN3/ESRP1/RBPJ/TRIOBP 4 GO:0042596 fear response 4/896 38/18722 0.10672503198437 0.382224533153324 DPP4/GJA1/ADRB1/EIF4G1 4 GO:0048713 regulation of oligodendrocyte differentiation 4/896 38/18722 0.10672503198437 0.382224533153324 DAG1/NF1/HDAC2/RHEB 4 GO:1901031 regulation of response to reactive oxygen species 4/896 38/18722 0.10672503198437 0.382224533153324 MET/BMP7/DHFR/PAWR 4 GO:0006835 dicarboxylic acid transport 7/896 84/18722 0.10715178469795 0.383465232494761 LRP2/ITGB1/GJA1/SLC26A2/ARL6IP1/SLC1A5/SLC13A3 7 GO:0051896 regulation of protein kinase B signaling 13/896 185/18722 0.107406613154202 0.383647193069167 LRP2/MET/EGFR/DAG1/HSP90AA1/ITGB1/TPBG/IGF1R/DLG1/GCNT2/PLEKHA1/RTN4/HSP90AB1 13 GO:0016925 protein sumoylation 5/896 53/18722 0.108498095145802 0.383647193069167 SAE1/ZNF451/TRIM28/RANBP2/UBA2 5 GO:0043620 regulation of DNA-templated transcription in response to stress 5/896 53/18722 0.108498095145802 0.383647193069167 CHEK1/NEDD4/HSPA5/BCLAF1/RBPJ 5 GO:1990090 cellular response to nerve growth factor stimulus 5/896 53/18722 0.108498095145802 0.383647193069167 APP/ID1/BPTF/DYNC1LI2/HSPA5 5 GO:0032409 regulation of transporter activity 20/896 310/18722 0.108539351885787 0.383647193069167 APP/TCAF1/ITGB1/GJA1/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/SLC5A3/AHCYL1/NEDD4/AKAP9/GOPC/KIF5B/FMR1/ATP1B3/AHNAK 20 GO:0090596 sensory organ morphogenesis 17/896 256/18722 0.108590159621897 0.383647193069167 FBN2/EFEMP1/FBN1/TENM3/BMP7/FAT1/LRP5/FZD5/NF1/FZD6/PTPRM/COL5A2/AHI1/TUG1/HDAC2/TRIOBP/HMGN1 17 GO:0030902 hindbrain development 11/896 151/18722 0.10918590591123 0.383647193069167 WLS/EZH2/BMP7/ITGB1/KIF14/NFIB/SLC6A4/RERE/AHI1/HNRNPD/HSPA5 11 GO:0071456 cellular response to hypoxia 11/896 151/18722 0.10918590591123 0.383647193069167 CCNB1/CCNA2/HP1BP3/BMP7/SLC29A1/ROCK2/DNMT3A/P4HB/NPEPPS/HILPDA/RBPJ 11 GO:0002328 pro-B cell differentiation 2/896 12/18722 0.109934930900423 0.383647193069167 PRKDC/SOX4 2 GO:0002424 T cell mediated immune response to tumor cell 2/896 12/18722 0.109934930900423 0.383647193069167 HMGB1/HSPD1 2 GO:0002903 negative regulation of B cell apoptotic process 2/896 12/18722 0.109934930900423 0.383647193069167 SLC39A10/AURKB 2 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/896 12/18722 0.109934930900423 0.383647193069167 SEC63/HSPA5 2 GO:0009086 methionine biosynthetic process 2/896 12/18722 0.109934930900423 0.383647193069167 MTR/MTAP 2 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 2/896 12/18722 0.109934930900423 0.383647193069167 TYMS/DUT 2 GO:0010587 miRNA catabolic process 2/896 12/18722 0.109934930900423 0.383647193069167 LIN28B/KCNQ1OT1 2 GO:0015780 nucleotide-sugar transmembrane transport 2/896 12/18722 0.109934930900423 0.383647193069167 SLC35B4/SLC35D1 2 GO:0021978 telencephalon regionalization 2/896 12/18722 0.109934930900423 0.383647193069167 ADGRG1/TRA2B 2 GO:0030397 membrane disassembly 2/896 12/18722 0.109934930900423 0.383647193069167 PLK1/VRK1 2 GO:0033127 regulation of histone phosphorylation 2/896 12/18722 0.109934930900423 0.383647193069167 CCNB1/FMR1 2 GO:0033235 positive regulation of protein sumoylation 2/896 12/18722 0.109934930900423 0.383647193069167 SAE1/UBA2 2 GO:0034333 adherens junction assembly 2/896 12/18722 0.109934930900423 0.383647193069167 DLG5/VCL 2 GO:0051639 actin filament network formation 2/896 12/18722 0.109934930900423 0.383647193069167 ACTN1/COBL 2 GO:0061430 bone trabecula morphogenesis 2/896 12/18722 0.109934930900423 0.383647193069167 FBN2/PLXNB1 2 GO:0070213 protein auto-ADP-ribosylation 2/896 12/18722 0.109934930900423 0.383647193069167 PARP1/PARP2 2 GO:0071287 cellular response to manganese ion 2/896 12/18722 0.109934930900423 0.383647193069167 APP/HSPA5 2 GO:0071472 cellular response to salt stress 2/896 12/18722 0.109934930900423 0.383647193069167 XRCC5/XRCC6 2 GO:0072015 glomerular visceral epithelial cell development 2/896 12/18722 0.109934930900423 0.383647193069167 ASXL1/IQGAP1 2 GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/896 12/18722 0.109934930900423 0.383647193069167 YAP1/CD24 2 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/896 12/18722 0.109934930900423 0.383647193069167 MET/PAWR 2 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 2/896 12/18722 0.109934930900423 0.383647193069167 NRP1/PLXNB1 2 GO:1904667 negative regulation of ubiquitin protein ligase activity 2/896 12/18722 0.109934930900423 0.383647193069167 MAD2L1/FBXO5 2 GO:1905666 regulation of protein localization to endosome 2/896 12/18722 0.109934930900423 0.383647193069167 ROCK2/RDX 2 GO:1990034 calcium ion export across plasma membrane 2/896 12/18722 0.109934930900423 0.383647193069167 ATP2B1/CALM2 2 GO:2000628 regulation of miRNA metabolic process 2/896 12/18722 0.109934930900423 0.383647193069167 LIN28B/KCNQ1OT1 2 GO:0031345 negative regulation of cell projection organization 13/896 186/18722 0.110726191114989 0.386126250097119 NRP1/SEMA6D/KANK1/CCP110/SEMA6A/YWHAH/YAP1/RYK/ID1/TACSTD2/HDAC2/LRP1/RTN4 13 GO:0045669 positive regulation of osteoblast differentiation 6/896 69/18722 0.111937955542302 0.390067007123321 FBN2/BMP7/FBXO5/LRP5/YAP1/SUCO 6 GO:0006413 translational initiation 9/896 118/18722 0.112622093753372 0.391878918060204 TPR/AGO2/EIF3A/KHDRBS1/LARP1/EIF4G1/FMR1/EIF1AX/RPS17 9 GO:0030203 glycosaminoglycan metabolic process 9/896 118/18722 0.112622093753372 0.391878918060204 ITIH5/HS6ST2/GCNT2/CHST14/CHPF/GUSB/HEXB/GLB1/CLTC 9 GO:0048638 regulation of developmental growth 21/896 330/18722 0.113103891114405 0.393268737203329 CCNB1/CDK1/PRKDC/APP/NRP1/SEMA6D/GJA1/PARP2/ADRB1/SEMA6A/SLC6A4/NRCAM/YAP1/RYK/GOLGA4/MACF1/TGFBR3/AFG3L2/LRP1/RBPJ/RTN4 21 GO:0051604 protein maturation 19/896 294/18722 0.11406848513894 0.394697637751918 MME/PERP/ENPEP/PARP1/ASPH/DHCR24/PRSS12/SOX4/LMF2/BCL2L12/GLG1/PRDX4/CPD/AFG3L2/CALR/HSPD1/SERPINH1/DNAJB11/CTSL 19 GO:0007618 mating 4/896 39/18722 0.114673825626884 0.394697637751918 APP/SLC6A4/HEXB/HDAC2 4 GO:0032728 positive regulation of interferon-beta production 4/896 39/18722 0.114673825626884 0.394697637751918 HMGB2/HMGB1/HSP90AA1/DHX9 4 GO:0051084 'de novo' posttranslational protein folding 4/896 39/18722 0.114673825626884 0.394697637751918 HSPA5/HSPA9/HSPA8/CCT2 4 GO:0086091 regulation of heart rate by cardiac conduction 4/896 39/18722 0.114673825626884 0.394697637751918 DSP/DSG2/DSC2/AKAP9 4 GO:1902742 apoptotic process involved in development 4/896 39/18722 0.114673825626884 0.394697637751918 BMP7/CHEK1/LRP5/FZD5 4 GO:0000244 spliceosomal tri-snRNP complex assembly 3/896 25/18722 0.115251048811515 0.394697637751918 SRSF10/PRPF8/LSM2 3 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 3/896 25/18722 0.115251048811515 0.394697637751918 GJA5/GJA1/EMP2 3 GO:0003094 glomerular filtration 3/896 25/18722 0.115251048811515 0.394697637751918 GJA5/GJA1/EMP2 3 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 3/896 25/18722 0.115251048811515 0.394697637751918 TYMS/DUT/DTYMK 3 GO:0016540 protein autoprocessing 3/896 25/18722 0.115251048811515 0.394697637751918 PARP1/AFG3L2/CTSL 3 GO:0021846 cell proliferation in forebrain 3/896 25/18722 0.115251048811515 0.394697637751918 RRM1/KIF14/PCM1 3 GO:0032878 regulation of establishment or maintenance of cell polarity 3/896 25/18722 0.115251048811515 0.394697637751918 KIF20B/KANK1/ROCK2 3 GO:0048143 astrocyte activation 3/896 25/18722 0.115251048811515 0.394697637751918 EGFR/APP/LRP1 3 GO:0051291 protein heterooligomerization 3/896 25/18722 0.115251048811515 0.394697637751918 RRM1/RRM2/PKD2 3 GO:0062009 secondary palate development 3/896 25/18722 0.115251048811515 0.394697637751918 ITGB8/DLG1/TGFBR3 3 GO:0072207 metanephric epithelium development 3/896 25/18722 0.115251048811515 0.394697637751918 PKD2/YAP1/LGR4 3 GO:0140448 signaling receptor ligand precursor processing 3/896 25/18722 0.115251048811515 0.394697637751918 MME/ENPEP/CTSL 3 GO:1900078 positive regulation of cellular response to insulin stimulus 3/896 25/18722 0.115251048811515 0.394697637751918 NUCKS1/SNX5/MYO1C 3 GO:1904385 cellular response to angiotensin 3/896 25/18722 0.115251048811515 0.394697637751918 CDC6/ROCK2/AHCYL1 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/896 25/18722 0.115251048811515 0.394697637751918 ADAMTS1/IQGAP1/LRP1 3 GO:0003002 regionalization 21/896 331/18722 0.115637805422962 0.395738267447472 LRP2/PRKDC/AURKA/NRP2/WLS/ADGRG1/NRP1/NR2F2/PGAP1/LRP5/XRCC2/FZD5/PBX1/COBL/MTF2/IRX2/AHI1/BPTF/HSPB11/RBPJ/TRA2B 21 GO:0071692 protein localization to extracellular region 23/896 368/18722 0.11639428584226 0.39804177694194 FBN2/MYH10/FBN1/EGFR/WLS/DPP4/PDIA4/GJA1/LRP5/EXPH5/LTBP1/SOX4/SLC16A1/FRMD4A/TM7SF3/CANX/CAMK2G/KIF5B/CD2AP/LRP1/FAM3B/IDH2/ERP29 23 GO:0031398 positive regulation of protein ubiquitination 9/896 119/18722 0.116990894632112 0.399795655671941 UBE2C/UBE2S/CDC20/BRCA1/FANCI/PLK1/SKP2/HSPA5/HUWE1 9 GO:0009798 axis specification 7/896 86/18722 0.117462100875781 0.400832072609706 AURKA/WLS/PGAP1/FZD5/COBL/AHI1/HSPB11 7 GO:0014031 mesenchymal cell development 7/896 86/18722 0.117462100875781 0.400832072609706 NRP2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A 7 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 6/896 70/18722 0.117785591850929 0.401648868211669 RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 6 GO:0016052 carbohydrate catabolic process 11/896 154/18722 0.120634452835289 0.41077666036781 HMGB1/APP/AGL/DHTKD1/LRP5/FUT8/ENOSF1/MANBA/GUSB/HEXB/GLB1 11 GO:0030856 regulation of epithelial cell differentiation 11/896 154/18722 0.120634452835289 0.41077666036781 EZH2/ESRP1/APOLD1/CCND1/ROCK2/YAP1/AHI1/VCL/ID1/CD24/NCOA3 11 GO:0046578 regulation of Ras protein signal transduction 13/896 189/18722 0.121043477553504 0.411871428227943 STMN1/MET/ADGRG1/ITGB1/NRP1/KANK1/KIF14/EPS8/FOXM1/ARFGEF3/RDX/NET1/RASA1 13 GO:0022613 ribonucleoprotein complex biogenesis 28/896 463/18722 0.121374809058843 0.411871428227943 PRKDC/HSP90AA1/PSIP1/NOP56/XPO1/EXOSC8/SRPK1/AGO2/SRSF10/DICER1/EIF3A/SF1/LUC7L3/DHX9/SNRPD1/PA2G4/RAN/LSM4/PRPF8/SCAF11/DDX17/LSM2/XRCC5/SNRPG/RPS21/SRSF5/RPS17/HSP90AB1 28 GO:0048593 camera-type eye morphogenesis 9/896 120/18722 0.121451244429302 0.411871428227943 TENM3/BMP7/FAT1/LRP5/FZD5/NF1/PTPRM/AHI1/HMGN1 9 GO:0050808 synapse organization 26/896 426/18722 0.122154461974103 0.411871428227943 TUBB/MYH10/CDH1/NRP2/APP/DAG1/CDC20/NRP1/TPBG/IGF1R/CLSTN1/ANK3/DLG1/FZD5/ACTN1/NRCAM/PPP1R9A/DLG5/NEDD4/PLXNB1/RYK/ZDHHC12/AFG3L2/EIF4G1/PPFIA1/HSPA8 26 GO:0007029 endoplasmic reticulum organization 7/896 87/18722 0.122803723431013 0.411871428227943 LMAN1/TMEM170A/ARL6IP1/CCDC47/TRAM2/EMC1/RTN4 7 GO:0019915 lipid storage 7/896 87/18722 0.122803723431013 0.411871428227943 ITGAV/CDS1/ASXL1/MEST/SQLE/HEXB/HILPDA 7 GO:0010001 glial cell differentiation 15/896 225/18722 0.122861696246124 0.411871428227943 CDK1/EGFR/APP/DAG1/ITGB4/PARD3/NFIB/SOX4/NF1/DICER1/CDK6/SPINT1/HDAC2/LRP1/RHEB 15 GO:0006730 one-carbon metabolic process 4/896 40/18722 0.122873886466602 0.411871428227943 TYMS/DHFR/SFXN1/AHCYL1 4 GO:0030501 positive regulation of bone mineralization 4/896 40/18722 0.122873886466602 0.411871428227943 FBN2/ATP2B1/BMP7/ANO6 4 GO:0031111 negative regulation of microtubule polymerization or depolymerization 4/896 40/18722 0.122873886466602 0.411871428227943 STMN1/TPX2/CKAP2/CAMSAP2 4 GO:0044275 cellular carbohydrate catabolic process 4/896 40/18722 0.122873886466602 0.411871428227943 HMGB1/AGL/ENOSF1/GUSB 4 GO:1901136 carbohydrate derivative catabolic process 12/896 172/18722 0.122999250256167 0.411871428227943 DUT/NUDT15/STT3B/UNG/MANBA/GUSB/HINT1/HEXB/GLB1/FUCA2/NUDT4/CTSL 12 GO:0003208 cardiac ventricle morphogenesis 6/896 71/18722 0.123782556604528 0.411871428227943 LRP2/DSP/SOX4/TGFBR3/LY6E/RBPJ 6 GO:0071230 cellular response to amino acid stimulus 6/896 71/18722 0.123782556604528 0.411871428227943 IPO5/GCLM/DNMT1/COL5A2/HNRNPD/DNMT3A 6 GO:0043414 macromolecule methylation 20/896 316/18722 0.124356745667788 0.411871428227943 HELLS/EZH2/PARP1/BRCA1/RIF1/SUZ12/ICMT/MIS18A/ZC3H13/MTF2/DNMT1/CTCF/TARBP1/DNMT3A/SETD2/PAXBP1/TRIM28/ASH1L/BRD4/ATRX 20 GO:1903364 positive regulation of cellular protein catabolic process 11/896 155/18722 0.124594864600823 0.411871428227943 LRP2/AURKA/CDC20/HSP90AA1/PLK1/TMTC3/RDX/FBXO22/RNF217/FMR1/LRP1 11 GO:0099111 microtubule-based transport 13/896 190/18722 0.124601320840384 0.411871428227943 APP/KIF4A/ARHGAP21/DST/PCM1/SFPQ/LRPPRC/HNRNPU/DYNC1H1/KIF5B/PURA/HSPB11/HSPA8 13 GO:0035107 appendage morphogenesis 10/896 138/18722 0.125672955423909 0.411871428227943 FBN2/BMP7/LRP5/FRAS1/FREM2/SOX4/PBX1/FZD6/HDAC2/ATRX 10 GO:0035108 limb morphogenesis 10/896 138/18722 0.125672955423909 0.411871428227943 FBN2/BMP7/LRP5/FRAS1/FREM2/SOX4/PBX1/FZD6/HDAC2/ATRX 10 GO:0021700 developmental maturation 18/896 280/18722 0.125734642075153 0.411871428227943 TYMS/CCNB1/BRCA2/AURKA/APP/DAG1/CDC20/FBXO5/CLSTN1/KIF14/CNTNAP2/FZD5/NRCAM/FERMT1/RERE/PLXNB1/TFCP2L1/RBPJ 18 GO:0002026 regulation of the force of heart contraction 3/896 26/18722 0.125893638792763 0.411871428227943 ATP1A1/ADRB1/ATP2A2 3 GO:0002407 dendritic cell chemotaxis 3/896 26/18722 0.125893638792763 0.411871428227943 HMGB1/CALR/ANO6 3 GO:0006760 folic acid-containing compound metabolic process 3/896 26/18722 0.125893638792763 0.411871428227943 TYMS/GGH/DHFR 3 GO:0021680 cerebellar Purkinje cell layer development 3/896 26/18722 0.125893638792763 0.411871428227943 KIF14/RERE/HSPA5 3 GO:0033598 mammary gland epithelial cell proliferation 3/896 26/18722 0.125893638792763 0.411871428227943 BRCA2/CCND1/RTN4 3 GO:0034063 stress granule assembly 3/896 26/18722 0.125893638792763 0.411871428227943 G3BP1/DYNC1H1/PRRC2C 3 GO:0048668 collateral sprouting 3/896 26/18722 0.125893638792763 0.411871428227943 APP/COBL/LRP1 3 GO:0097205 renal filtration 3/896 26/18722 0.125893638792763 0.411871428227943 GJA5/GJA1/EMP2 3 GO:1904376 negative regulation of protein localization to cell periphery 3/896 26/18722 0.125893638792763 0.411871428227943 GOPC/PPFIA1/CLTC 3 GO:0003334 keratinocyte development 2/896 13/18722 0.125959841896271 0.411871428227943 EXPH5/PALLD 2 GO:0006983 ER overload response 2/896 13/18722 0.125959841896271 0.411871428227943 CCDC47/HSPA5 2 GO:0009143 nucleoside triphosphate catabolic process 2/896 13/18722 0.125959841896271 0.411871428227943 DUT/NUDT15 2 GO:0009650 UV protection 2/896 13/18722 0.125959841896271 0.411871428227943 FEN1/SCARA3 2 GO:0010958 regulation of amino acid import across plasma membrane 2/896 13/18722 0.125959841896271 0.411871428227943 ITGB1/ARL6IP1 2 GO:0016078 tRNA catabolic process 2/896 13/18722 0.125959841896271 0.411871428227943 EXOSC8/DICER1 2 GO:0030497 fatty acid elongation 2/896 13/18722 0.125959841896271 0.411871428227943 HACD3/TECR 2 GO:0031053 primary miRNA processing 2/896 13/18722 0.125959841896271 0.411871428227943 LIN28B/HNRNPA2B1 2 GO:0032230 positive regulation of synaptic transmission, GABAergic 2/896 13/18722 0.125959841896271 0.411871428227943 ZDHHC12/KIF5B 2 GO:0032429 regulation of phospholipase A2 activity 2/896 13/18722 0.125959841896271 0.411871428227943 EGFR/LRP1 2 GO:0035331 negative regulation of hippo signaling 2/896 13/18722 0.125959841896271 0.411871428227943 CIT/DLG5 2 GO:0042538 hyperosmotic salinity response 2/896 13/18722 0.125959841896271 0.411871428227943 XRCC5/XRCC6 2 GO:0042659 regulation of cell fate specification 2/896 13/18722 0.125959841896271 0.411871428227943 ESRP1/LMO4 2 GO:0042761 very long-chain fatty acid biosynthetic process 2/896 13/18722 0.125959841896271 0.411871428227943 HACD3/TECR 2 GO:0043928 exonucleolytic catabolism of deadenylated mRNA 2/896 13/18722 0.125959841896271 0.411871428227943 EXOSC8/DCP2 2 GO:0044794 positive regulation by host of viral process 2/896 13/18722 0.125959841896271 0.411871428227943 NUCKS1/HSPA8 2 GO:0048820 hair follicle maturation 2/896 13/18722 0.125959841896271 0.411871428227943 FERMT1/RBPJ 2 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/896 13/18722 0.125959841896271 0.411871428227943 PKD2/CALM2 2 GO:0051481 negative regulation of cytosolic calcium ion concentration 2/896 13/18722 0.125959841896271 0.411871428227943 ATP2B1/LRP1 2 GO:0060347 heart trabecula formation 2/896 13/18722 0.125959841896271 0.411871428227943 ADAMTS1/TGFBR3 2 GO:0061000 negative regulation of dendritic spine development 2/896 13/18722 0.125959841896271 0.411871428227943 ASAP1/HDAC2 2 GO:0070914 UV-damage excision repair 2/896 13/18722 0.125959841896271 0.411871428227943 POLD3/DDB1 2 GO:0071696 ectodermal placode development 2/896 13/18722 0.125959841896271 0.411871428227943 NRP1/HDAC2 2 GO:0072310 glomerular epithelial cell development 2/896 13/18722 0.125959841896271 0.411871428227943 ASXL1/IQGAP1 2 GO:0090158 endoplasmic reticulum membrane organization 2/896 13/18722 0.125959841896271 0.411871428227943 ARL6IP1/RTN4 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/896 13/18722 0.125959841896271 0.411871428227943 APP/PPP1R9A 2 GO:1900452 regulation of long-term synaptic depression 2/896 13/18722 0.125959841896271 0.411871428227943 PPP1R9A/FMR1 2 GO:1902947 regulation of tau-protein kinase activity 2/896 13/18722 0.125959841896271 0.411871428227943 HSP90AA1/HSP90AB1 2 GO:1903789 regulation of amino acid transmembrane transport 2/896 13/18722 0.125959841896271 0.411871428227943 ITGB1/ARL6IP1 2 GO:0051495 positive regulation of cytoskeleton organization 15/896 226/18722 0.126137821063633 0.412171086760974 MET/IQGAP2/NRP1/GPSM2/CKAP5/CEP295/CENPJ/CDK5RAP2/DLG1/ROCK2/MYO1C/DYNC1H1/ID1/CLIP1/AKAP9 15 GO:1901657 glycosyl compound metabolic process 7/896 88/18722 0.128267318581694 0.418842803631333 TK1/DTYMK/PPAT/GUSB/MTAP/FUCA2/AKR7A2 7 GO:0035051 cardiocyte differentiation 11/896 156/18722 0.1286266154565 0.419208367560948 CCNB1/CDK1/EGFR/BMP7/ITGB1/PARP2/HNRNPU/TGFBR3/CALR/RBPJ/CACYBP 11 GO:0006470 protein dephosphorylation 18/896 281/18722 0.128700377929506 0.419208367560948 CDKN3/HSP90B1/SLC39A10/CDCA2/PTPN14/MASTL/DLG1/CALM2/CTDSPL2/ROCK2/PTPRM/CTDSPL/ANKLE2/PPM1G/PGP/PPP4R1/CAMK2G/HSP90AB1 18 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 5/896 56/18722 0.128993944689366 0.419208367560948 EXOSC8/AGO2/TNRC6A/DCP2/CNOT1 5 GO:0043388 positive regulation of DNA binding 5/896 56/18722 0.128993944689366 0.419208367560948 HMGB2/HMGB1/PARP1/CALM2/TRIM28 5 GO:0098781 ncRNA transcription 5/896 56/18722 0.128993944689366 0.419208367560948 TCOF1/ICE1/SMARCA4/NCL/POLR2L 5 GO:1904645 response to amyloid-beta 5/896 56/18722 0.128993944689366 0.419208367560948 APP/PARP1/GJA1/IGF1R/LRP1 5 GO:1990089 response to nerve growth factor 5/896 56/18722 0.128993944689366 0.419208367560948 APP/ID1/BPTF/DYNC1LI2/HSPA5 5 GO:0030330 DNA damage response, signal transduction by p53 class mediator 6/896 72/18722 0.129925990671916 0.421663276320685 GTSE1/BRCA2/FOXM1/SOX4/USP10/ATRX 6 GO:0043903 regulation of biological process involved in symbiotic interaction 6/896 72/18722 0.129925990671916 0.421663276320685 ITGAV/P4HB/TRIM28/LY6E/FUCA2/DDB1 6 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 8/896 105/18722 0.130250097905182 0.422427966983248 ANLN/NRP1/EPS8/CCP110/CEP135/COBL/ATMIN/FMR1 8 GO:0009167 purine ribonucleoside monophosphate metabolic process 4/896 41/18722 0.131315547747071 0.424729285192762 GMPS/DLG1/PPAT/PAICS 4 GO:0071470 cellular response to osmotic stress 4/896 41/18722 0.131315547747071 0.424729285192762 PKD2/SLC2A1/XRCC5/XRCC6 4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 4/896 41/18722 0.131315547747071 0.424729285192762 NRP1/P4HB/CALR/TRIOBP 4 GO:1902116 negative regulation of organelle assembly 4/896 41/18722 0.131315547747071 0.424729285192762 BRCA1/CDK5RAP2/CCP110/YAP1 4 GO:0032868 response to insulin 17/896 264/18722 0.132334809086505 0.427736207568702 GGH/PRKDC/NUCKS1/ATP2B1/PARP1/KANK1/IGF1R/PHIP/SOGA1/PPAT/SMARCC1/SNX5/SRSF4/MYO1C/HADHA/SLC2A1/SRSF5 17 GO:1990845 adaptive thermogenesis 11/896 157/18722 0.132729165689418 0.42823168837072 GJA1/IGF1R/ADRB1/LGR4/PRLR/HNRNPU/DYNC1H1/ID1/RBPJ/RHEB/SLC25A5 11 GO:0003007 heart morphogenesis 16/896 246/18722 0.132730868529946 0.42823168837072 LRP2/DSP/NRP2/BMP7/NRP1/GJA5/ADAMTS1/PKD2/SOX4/YAP1/AHI1/ASXL1/TGFBR3/LY6E/RBPJ/RTN4 16 GO:1901214 regulation of neuron death 20/896 319/18722 0.132757205443792 0.42823168837072 PARP1/NRP1/DHCR24/KIF14/MSH2/XRCC2/MYBL2/PARP2/NF1/GCLM/NAE1/SET/OXR1/HSPD1/EIF4G1/LRP1/NONO/SERPINF1/RASA1/HSP90AB1 20 GO:2001233 regulation of apoptotic signaling pathway 22/896 356/18722 0.132964502497158 0.428610759568828 HMGB2/HELLS/ITGA6/PARP1/ITGAV/BRCA1/NRP1/PHIP/RTKN2/FIGNL1/GCLM/YAP1/SFPQ/BCL2L12/PDIA3/P4HB/USP47/NONO/MAGED1/BCLAF1/ERP29/SLC25A5 22 GO:0018209 peptidyl-serine modification 21/896 338/18722 0.134342302488191 0.432759886692727 CCNB1/CDK1/PRKDC/EGFR/AURKA/APP/CLSPN/PARP1/HSP90AA1/AURKB/TTK/PLK1/VRK1/PARP2/MASTL/ROCK2/PKN2/CDK2/AKAP9/EIF4G1/HSP90AB1 21 GO:0046620 regulation of organ growth 8/896 106/18722 0.135370580515438 0.435492124879893 CCNB1/CDK1/GJA1/PARP2/SLC6A4/YAP1/TGFBR3/RBPJ 8 GO:0003231 cardiac ventricle development 9/896 123/18722 0.135372918584366 0.435492124879893 LRP2/DSP/GJA5/SOX4/TGFBR3/LY6E/TRIP11/RBPJ/LMO4 9 GO:0030522 intracellular receptor signaling pathway 17/896 265/18722 0.1354985493807 0.43560274393499 EZH2/PARP1/BRCA1/NR2F2/DCBLD2/YWHAH/YAP1/SKP2/NEDD4/ASXL1/SMARCA4/TRIM24/CNOT1/CALR/PUM1/UFL1/DDX17 17 GO:0051205 protein insertion into membrane 5/896 57/18722 0.136190794314013 0.436200873730816 EGFR/HSP90AA1/CCDC47/TRAM2/EMC1 5 GO:0061005 cell differentiation involved in kidney development 5/896 57/18722 0.136190794314013 0.436200873730816 YAP1/LGR4/ASXL1/IQGAP1/CD24 5 GO:0007026 negative regulation of microtubule depolymerization 3/896 27/18722 0.136872414924332 0.436200873730816 TPX2/CKAP2/CAMSAP2 3 GO:0009651 response to salt stress 3/896 27/18722 0.136872414924332 0.436200873730816 XRCC5/XRCC6/HSP90AB1 3 GO:0031954 positive regulation of protein autophosphorylation 3/896 27/18722 0.136872414924332 0.436200873730816 CALM2/IQGAP1/RAD50 3 GO:0032781 positive regulation of ATPase activity 3/896 27/18722 0.136872414924332 0.436200873730816 DNAJC9/ATP1B3/DNAJB11 3 GO:0033688 regulation of osteoblast proliferation 3/896 27/18722 0.136872414924332 0.436200873730816 ITGAV/LRP5/PLXNB1 3 GO:0034453 microtubule anchoring 3/896 27/18722 0.136872414924332 0.436200873730816 DAG1/PCM1/CEP57 3 GO:0061437 renal system vasculature development 3/896 27/18722 0.136872414924332 0.436200873730816 BMP7/NRP1/PKD2 3 GO:0061440 kidney vasculature development 3/896 27/18722 0.136872414924332 0.436200873730816 BMP7/NRP1/PKD2 3 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 3/896 27/18722 0.136872414924332 0.436200873730816 ALG10B/AKAP9/ATP1B3 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/896 27/18722 0.136872414924332 0.436200873730816 PARP1/OXR1/NONO 3 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 3/896 27/18722 0.136872414924332 0.436200873730816 PARP1/HNRNPU/DCP2 3 GO:0001558 regulation of cell growth 25/896 414/18722 0.138494719273976 0.441076577594371 EGFR/SMARCA2/NRP1/SEMA6D/CHPT1/GJA1/TMEM97/CLSTN1/KIF14/DCBLD2/PARP2/SEMA6A/NRCAM/CDKN2A/RYK/SMARCA4/GOLGA4/NET1/MACF1/EIF4G1/EPB41L3/RBBP7/LRP1/USP47/RTN4 25 GO:0033002 muscle cell proliferation 16/896 248/18722 0.13935572415739 0.44352281808492 CCNB1/CDK1/PRKDC/EGFR/GJA1/ADAMTS1/YAP1/SKP2/DNMT1/SF1/PAXBP1/TGFBR3/RBPJ/XRCC5/XRCC6/TGM2 16 GO:0000413 protein peptidyl-prolyl isomerization 4/896 42/18722 0.139988752457245 0.443913108803431 PPIC/NKTR/RANBP2/PPIG 4 GO:0033574 response to testosterone 4/896 42/18722 0.139988752457245 0.443913108803431 NASP/ROCK2/MTAP/CALR 4 GO:0045773 positive regulation of axon extension 4/896 42/18722 0.139988752457245 0.443913108803431 NRP1/GOLGA4/MACF1/LRP1 4 GO:0071312 cellular response to alkaloid 4/896 42/18722 0.139988752457245 0.443913108803431 CCNA2/RAD51/BLM/TGM2 4 GO:0090317 negative regulation of intracellular protein transport 4/896 42/18722 0.139988752457245 0.443913108803431 LMAN1/BARD1/FERMT1/UBE2G2 4 GO:0032526 response to retinoic acid 8/896 107/18722 0.1405915954921 0.443913108803431 SUZ12/GJA1/SLC6A4/YAP1/ASXL1/YES1/HDAC2/SERPINF1 8 GO:0042303 molting cycle 8/896 107/18722 0.1405915954921 0.443913108803431 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0042633 hair cycle 8/896 107/18722 0.1405915954921 0.443913108803431 EGFR/LGR5/LAMA5/FZD6/FERMT1/LGR4/HDAC2/RBPJ 8 GO:0000054 ribosomal subunit export from nucleus 2/896 14/18722 0.142490608114327 0.443913108803431 XPO1/RAN 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/896 14/18722 0.142490608114327 0.443913108803431 TRIP11/SERPINH1 2 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 2/896 14/18722 0.142490608114327 0.443913108803431 TYMS/DUT 2 GO:0010421 hydrogen peroxide-mediated programmed cell death 2/896 14/18722 0.142490608114327 0.443913108803431 MET/PAWR 2 GO:0010457 centriole-centriole cohesion 2/896 14/18722 0.142490608114327 0.443913108803431 NEK2/CEP135 2 GO:0030007 cellular potassium ion homeostasis 2/896 14/18722 0.142490608114327 0.443913108803431 ATP1A1/ATP1B3 2 GO:0033750 ribosome localization 2/896 14/18722 0.142490608114327 0.443913108803431 XPO1/RAN 2 GO:0035563 positive regulation of chromatin binding 2/896 14/18722 0.142490608114327 0.443913108803431 GMNN/CDT1 2 GO:0035672 oligopeptide transmembrane transport 2/896 14/18722 0.142490608114327 0.443913108803431 GJA1/SLC13A3 2 GO:0038166 angiotensin-activated signaling pathway 2/896 14/18722 0.142490608114327 0.443913108803431 ROCK2/AHCYL1 2 GO:0045472 response to ether 2/896 14/18722 0.142490608114327 0.443913108803431 HNRNPD/LARP1 2 GO:0048291 isotype switching to IgG isotypes 2/896 14/18722 0.142490608114327 0.443913108803431 MSH2/HSPD1 2 GO:0051589 negative regulation of neurotransmitter transport 2/896 14/18722 0.142490608114327 0.443913108803431 PPP1R9A/FMR1 2 GO:0051764 actin crosslink formation 2/896 14/18722 0.142490608114327 0.443913108803431 EPS8/GAS2L3 2 GO:0070986 left/right axis specification 2/896 14/18722 0.142490608114327 0.443913108803431 AHI1/HSPB11 2 GO:0071236 cellular response to antibiotic 2/896 14/18722 0.142490608114327 0.443913108803431 EZH2/HSPA5 2 GO:0071285 cellular response to lithium ion 2/896 14/18722 0.142490608114327 0.443913108803431 CDH1/CALR 2 GO:0072160 nephron tubule epithelial cell differentiation 2/896 14/18722 0.142490608114327 0.443913108803431 YAP1/CD24 2 GO:0072176 nephric duct development 2/896 14/18722 0.142490608114327 0.443913108803431 PKD2/AHI1 2 GO:0072531 pyrimidine-containing compound transmembrane transport 2/896 14/18722 0.142490608114327 0.443913108803431 SLC29A1/SLC25A36 2 GO:0090128 regulation of synapse maturation 2/896 14/18722 0.142490608114327 0.443913108803431 CDC20/CLSTN1 2 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 2/896 14/18722 0.142490608114327 0.443913108803431 DNMT1/TRIM28 2 GO:1902036 regulation of hematopoietic stem cell differentiation 2/896 14/18722 0.142490608114327 0.443913108803431 PRKDC/HSPA9 2 GO:1903894 regulation of IRE1-mediated unfolded protein response 2/896 14/18722 0.142490608114327 0.443913108803431 HSPA5/UFL1 2 GO:0048332 mesoderm morphogenesis 6/896 74/18722 0.142639863616352 0.443913108803431 WLS/BMP7/ITGB1/ITGB4/GJA1/SETD2 6 GO:0070972 protein localization to endoplasmic reticulum 6/896 74/18722 0.142639863616352 0.443913108803431 GJA1/GPAA1/TRAM2/SEC63/HSPA5/RTN4 6 GO:0032387 negative regulation of intracellular transport 5/896 58/18722 0.143561322239879 0.446199057534625 LMAN1/BARD1/TPR/FERMT1/UBE2G2 5 GO:2000649 regulation of sodium ion transmembrane transporter activity 5/896 58/18722 0.143561322239879 0.446199057534625 ANK3/YWHAH/UTRN/NEDD4/KIF5B 5 GO:0014033 neural crest cell differentiation 7/896 91/18722 0.145369968623883 0.451232919512626 NRP2/BMP7/NRP1/SEMA6D/LAMA5/TCOF1/SEMA6A 7 GO:0051492 regulation of stress fiber assembly 7/896 91/18722 0.145369968623883 0.451232919512626 STMN1/MET/NRP1/ROCK2/PPP1R9A/TACSTD2/PPFIA1 7 GO:0035725 sodium ion transmembrane transport 12/896 178/18722 0.146641455826091 0.454883892211669 SLC20A1/ATP1A1/ANK3/PKD2/DLG1/YWHAH/SLC6A4/UTRN/NEDD4/KIF5B/ATP1B3/ANO6 12 GO:0001945 lymph vessel development 3/896 28/18722 0.14816311866917 0.456931995172233 NR2F2/SVEP1/PTPN14 3 GO:0006516 glycoprotein catabolic process 3/896 28/18722 0.14816311866917 0.456931995172233 STT3B/MANBA/CTSL 3 GO:0006972 hyperosmotic response 3/896 28/18722 0.14816311866917 0.456931995172233 SLC2A1/XRCC5/XRCC6 3 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 3/896 28/18722 0.14816311866917 0.456931995172233 PARD3/DGKD/LRP1 3 GO:0031440 regulation of mRNA 3'-end processing 3/896 28/18722 0.14816311866917 0.456931995172233 CCNB1/BARD1/AHCYL1 3 GO:0032801 receptor catabolic process 3/896 28/18722 0.14816311866917 0.456931995172233 RNF43/ZNRF3/NEDD4 3 GO:0051503 adenine nucleotide transport 3/896 28/18722 0.14816311866917 0.456931995172233 SLC29A1/GJA1/SLC25A5 3 GO:0060325 face morphogenesis 3/896 28/18722 0.14816311866917 0.456931995172233 CRISPLD1/ANKRD11/PLEKHA1 3 GO:1903779 regulation of cardiac conduction 3/896 28/18722 0.14816311866917 0.456931995172233 ATP2B1/GJA5/ATP2A2 3 GO:0001504 neurotransmitter uptake 4/896 43/18722 0.148883108886927 0.45796904756842 SLC29A1/ITGB1/SLC38A1/SLC6A4 4 GO:0010171 body morphogenesis 4/896 43/18722 0.148883108886927 0.45796904756842 DAG1/CRISPLD1/ANKRD11/PLEKHA1 4 GO:0034661 ncRNA catabolic process 4/896 43/18722 0.148883108886927 0.45796904756842 EXOSC8/LIN28B/DICER1/KCNQ1OT1 4 GO:1901381 positive regulation of potassium ion transmembrane transport 4/896 43/18722 0.148883108886927 0.45796904756842 ALG10B/AKAP9/ATP1B3/ANO6 4 GO:0006094 gluconeogenesis 6/896 75/18722 0.149203648608344 0.458364361940949 SLC35B4/SOGA1/PGP/SLC25A1/RANBP2/DDB1 6 GO:0043627 response to estrogen 6/896 75/18722 0.149203648608344 0.458364361940949 BRCA1/DTYMK/CCND1/TRIM24/HSPD1/CD24 6 GO:0036294 cellular response to decreased oxygen levels 11/896 161/18722 0.149834876912699 0.460007525647089 CCNB1/CCNA2/HP1BP3/BMP7/SLC29A1/ROCK2/DNMT3A/P4HB/NPEPPS/HILPDA/RBPJ 11 GO:0007416 synapse assembly 12/896 179/18722 0.150801056810213 0.462676250136218 CDH1/APP/TPBG/CLSTN1/FZD5/NRCAM/PPP1R9A/DLG5/PLXNB1/RYK/ZDHHC12/EIF4G1 12 GO:0035306 positive regulation of dephosphorylation 5/896 59/18722 0.151099890035211 0.463295359684071 SLC39A10/CDCA2/CALM2/ANKLE2/HSP90AB1 5 GO:0032414 positive regulation of ion transmembrane transporter activity 8/896 109/18722 0.151328904879517 0.46369973805829 TCAF1/ANK3/PKD2/ALG10B/CALM2/AKAP9/KIF5B/ATP1B3 8 GO:0030336 negative regulation of cell migration 21/896 344/18722 0.151706344721107 0.464558107568035 HMGB1/CDH1/DAG1/TCAF1/ADGRG1/DPP4/SEMA6D/NR2F2/GJA1/MARVELD3/KANK1/NF1/PTPRM/DLG5/VCL/CALR/STK24/TACSTD2/LRP1/SERPINF1/IDH2 21 GO:0009612 response to mechanical stimulus 14/896 216/18722 0.154818260034301 0.471617762576397 CCNB1/EGFR/DAG1/GJA1/CHEK1/ATP1A1/CNTNAP2/CASP8AP2/MEIS2/PKD2/SLC38A2/USP53/TMEM150C/SLC2A1 14 GO:0043409 negative regulation of MAPK cascade 12/896 180/18722 0.155021728096249 0.471617762576397 DAG1/PBK/BMP7/MARVELD3/IGF1R/FOXM1/SEMA6A/DLG1/NF1/EIF3A/FBLN1/ASH1L 12 GO:0006809 nitric oxide biosynthetic process 6/896 76/18722 0.15590061614637 0.471617762576397 HSP90AA1/PKD2/ROCK2/CYB5B/KHSRP/HSP90AB1 6 GO:0009408 response to heat 8/896 110/18722 0.156841810158296 0.471617762576397 HSP90AA1/PSIP1/TPR/ATP2A2/HSPD1/HDAC2/RBBP7/HSP90AB1 8 GO:0071375 cellular response to peptide hormone stimulus 18/896 290/18722 0.157201811987109 0.471617762576397 CCNA2/PRKDC/NUCKS1/FBN1/ATP2B1/PARP1/CDC6/KANK1/IGF1R/PHIP/SOGA1/PPAT/ROCK2/SMARCC1/SNX5/AHCYL1/MYO1C/SRSF5 18 GO:0007528 neuromuscular junction development 4/896 44/18722 0.157987943816573 0.471617762576397 APP/ANK3/NEDD4/AFG3L2 4 GO:0008542 visual learning 4/896 44/18722 0.157987943816573 0.471617762576397 APP/ITGB1/MEIS2/NF1 4 GO:0009126 purine nucleoside monophosphate metabolic process 4/896 44/18722 0.157987943816573 0.471617762576397 GMPS/DLG1/PPAT/PAICS 4 GO:0021762 substantia nigra development 4/896 44/18722 0.157987943816573 0.471617762576397 CCDC14/YWHAH/CALM2/HSPA5 4 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 4/896 44/18722 0.157987943816573 0.471617762576397 FAT1/PARD3/DLG1/DLG5 4 GO:0010976 positive regulation of neuron projection development 11/896 163/18722 0.158794987042625 0.471617762576397 ITGA6/TENM3/EZH2/BMP7/COBL/VLDLR/PPP1R9A/IQGAP1/HSPA5/LRP1/SERPINF1 11 GO:0071322 cellular response to carbohydrate stimulus 11/896 163/18722 0.158794987042625 0.471617762576397 COLEC12/SLC29A1/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 11 GO:0006893 Golgi to plasma membrane transport 5/896 60/18722 0.158800639875352 0.471617762576397 SPTBN1/ANK3/GOLGA4/MACF1/GOPC 5 GO:0031638 zymogen activation 5/896 60/18722 0.158800639875352 0.471617762576397 PERP/ASPH/DHCR24/PRSS12/CTSL 5 GO:0055008 cardiac muscle tissue morphogenesis 5/896 60/18722 0.158800639875352 0.471617762576397 LRP2/DSP/TGFBR3/LY6E/RBPJ 5 GO:0061951 establishment of protein localization to plasma membrane 5/896 60/18722 0.158800639875352 0.471617762576397 SPTBN1/ANK3/GOLGA4/MACF1/GOPC 5 GO:0014706 striated muscle tissue development 23/896 384/18722 0.159183883902684 0.471617762576397 CENPF/CCNB1/LRP2/CDK1/DSP/DSG2/BMP7/ITGB1/NR2F2/GJA5/GJA1/SVIL/PARP2/KLF5/YAP1/HNRNPU/FBXO22/TGFBR3/CALR/LY6E/RBPJ/CACYBP/DDX17 23 GO:0008361 regulation of cell size 12/896 181/18722 0.159302797474767 0.471617762576397 NRP1/SEMA6D/SEMA6A/NRCAM/RDX/RYK/GOLGA4/MACF1/ANO6/LRP1/RTN4/HSP90AB1 12 GO:0001325 formation of extrachromosomal circular DNA 2/896 15/18722 0.159442249418411 0.471617762576397 BLM/XRCC5 2 GO:0002070 epithelial cell maturation 2/896 15/18722 0.159442249418411 0.471617762576397 TYMS/TFCP2L1 2 GO:0006878 cellular copper ion homeostasis 2/896 15/18722 0.159442249418411 0.471617762576397 APP/MT2A 2 GO:0009163 nucleoside biosynthetic process 2/896 15/18722 0.159442249418411 0.471617762576397 DTYMK/MTAP 2 GO:0014733 regulation of skeletal muscle adaptation 2/896 15/18722 0.159442249418411 0.471617762576397 ATP2A2/CAMK2G 2 GO:0019511 peptidyl-proline hydroxylation 2/896 15/18722 0.159442249418411 0.471617762576397 P4HB/PRDX4 2 GO:0032354 response to follicle-stimulating hormone 2/896 15/18722 0.159442249418411 0.471617762576397 GCLM/TGFBR3 2 GO:0032486 Rap protein signal transduction 2/896 15/18722 0.159442249418411 0.471617762576397 KIF14/RDX 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/896 15/18722 0.159442249418411 0.471617762576397 BRCA1/CNOT1 2 GO:0034404 nucleobase-containing small molecule biosynthetic process 2/896 15/18722 0.159442249418411 0.471617762576397 DTYMK/MTAP 2 GO:0035435 phosphate ion transmembrane transport 2/896 15/18722 0.159442249418411 0.471617762576397 SLC20A1/ANKH 2 GO:0036376 sodium ion export across plasma membrane 2/896 15/18722 0.159442249418411 0.471617762576397 ATP1A1/ATP1B3 2 GO:0042074 cell migration involved in gastrulation 2/896 15/18722 0.159442249418411 0.471617762576397 AMOT/LRP5 2 GO:0048308 organelle inheritance 2/896 15/18722 0.159442249418411 0.471617762576397 CDK1/VRK1 2 GO:0048313 Golgi inheritance 2/896 15/18722 0.159442249418411 0.471617762576397 CDK1/VRK1 2 GO:0050746 regulation of lipoprotein metabolic process 2/896 15/18722 0.159442249418411 0.471617762576397 ITGAV/DBI 2 GO:0051284 positive regulation of sequestering of calcium ion 2/896 15/18722 0.159442249418411 0.471617762576397 PKD2/CALM2 2 GO:0051938 L-glutamate import 2/896 15/18722 0.159442249418411 0.471617762576397 ITGB1/ARL6IP1 2 GO:0055012 ventricular cardiac muscle cell differentiation 2/896 15/18722 0.159442249418411 0.471617762576397 CCNB1/CDK1 2 GO:0060253 negative regulation of glial cell proliferation 2/896 15/18722 0.159442249418411 0.471617762576397 DICER1/IDH2 2 GO:0070831 basement membrane assembly 2/896 15/18722 0.159442249418411 0.471617762576397 LAMB1/DAG1 2 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 2/896 15/18722 0.159442249418411 0.471617762576397 XPO1/RAN 2 GO:0072075 metanephric mesenchyme development 2/896 15/18722 0.159442249418411 0.471617762576397 BMP7/PKD2 2 GO:0090656 t-circle formation 2/896 15/18722 0.159442249418411 0.471617762576397 BLM/XRCC5 2 GO:0090737 telomere maintenance via telomere trimming 2/896 15/18722 0.159442249418411 0.471617762576397 BLM/XRCC5 2 GO:0097468 programmed cell death in response to reactive oxygen species 2/896 15/18722 0.159442249418411 0.471617762576397 MET/PAWR 2 GO:0098712 L-glutamate import across plasma membrane 2/896 15/18722 0.159442249418411 0.471617762576397 ITGB1/ARL6IP1 2 GO:0110156 methylguanosine-cap decapping 2/896 15/18722 0.159442249418411 0.471617762576397 DCP2/PNRC2 2 GO:1900029 positive regulation of ruffle assembly 2/896 15/18722 0.159442249418411 0.471617762576397 EPS8/COBL 2 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/896 15/18722 0.159442249418411 0.471617762576397 HSPA5/UFL1 2 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/896 15/18722 0.159442249418411 0.471617762576397 AGO2/CNOT1 2 GO:1901660 calcium ion export 2/896 15/18722 0.159442249418411 0.471617762576397 ATP2B1/CALM2 2 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 2/896 15/18722 0.159442249418411 0.471617762576397 SMARCA4/NCL 2 GO:1902018 negative regulation of cilium assembly 2/896 15/18722 0.159442249418411 0.471617762576397 CCP110/YAP1 2 GO:1904424 regulation of GTP binding 2/896 15/18722 0.159442249418411 0.471617762576397 STMN1/MET 2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/896 29/18722 0.159741500227489 0.471617762576397 AGO2/TNRC6A/CNOT1 3 GO:0001773 myeloid dendritic cell activation 3/896 29/18722 0.159741500227489 0.471617762576397 HMGB1/ITGB8/RBPJ 3 GO:0015868 purine ribonucleotide transport 3/896 29/18722 0.159741500227489 0.471617762576397 SLC29A1/GJA1/SLC25A5 3 GO:0060441 epithelial tube branching involved in lung morphogenesis 3/896 29/18722 0.159741500227489 0.471617762576397 DAG1/YAP1/DLG5 3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 3/896 29/18722 0.159741500227489 0.471617762576397 DEK/PRKDC/RIF1 3 GO:0021675 nerve development 6/896 77/18722 0.162727034398667 0.479838704273771 NRP2/DAG1/NRP1/CTSV/DICER1/AFG3L2 6 GO:0031016 pancreas development 6/896 77/18722 0.162727034398667 0.479838704273771 MET/WLS/MEIS2/SOX4/CDK6/RHEB 6 GO:0052547 regulation of peptidase activity 27/896 461/18722 0.162830629848185 0.479847794379774 HMGB1/PTTG1/BIRC5/APLP2/ITIH5/APP/PERP/ASPH/DHCR24/CASP8AP2/CRIM1/ROCK2/ARL6IP1/BCL2L12/FBLN1/SPINT1/SPINT2/HSPD1/ANP32B/LRP1/SERPINH1/USP14/USP47/PCOLCE2/SERPINF1/CLDN4/PSMD14 27 GO:0001738 morphogenesis of a polarized epithelium 7/896 94/18722 0.163493060617759 0.481502696723739 LAMA5/FAT1/ZNRF3/FZD6/AHI1/DLG5/RYK 7 GO:0006022 aminoglycan metabolic process 9/896 129/18722 0.165552108647492 0.486965968381471 ITIH5/HS6ST2/GCNT2/CHST14/CHPF/GUSB/HEXB/GLB1/CLTC 9 GO:0034101 erythrocyte homeostasis 9/896 129/18722 0.165552108647492 0.486965968381471 HMGB2/PRKDC/NCAPG2/CDK6/TGFBR3/HSPA9/UFL1/RPS17/SLC25A5 9 GO:0060998 regulation of dendritic spine development 5/896 61/18722 0.166657516267168 0.489915629716417 PPP1R9A/DLG5/FMR1/ASAP1/HDAC2 5 GO:0003254 regulation of membrane depolarization 4/896 45/18722 0.167292353254287 0.490875042677299 PARP1/GJA5/ANK3/GCLM 4 GO:1901985 positive regulation of protein acetylation 4/896 45/18722 0.167292353254287 0.490875042677299 BRCA1/CEP295/SOX4/BRD7 4 GO:2000273 positive regulation of signaling receptor activity 4/896 45/18722 0.167292353254287 0.490875042677299 ITGB1/NRP1/HDAC2/NCOA3 4 GO:0048640 negative regulation of developmental growth 8/896 112/18722 0.16814699331061 0.492777008020167 NRP1/SEMA6D/GJA1/ADRB1/SEMA6A/SLC6A4/RYK/RTN4 8 GO:1901222 regulation of NIK/NF-kappaB signaling 8/896 112/18722 0.16814699331061 0.492777008020167 HMGB1/EGFR/APP/BMP7/RTKN2/NFAT5/CALR/TRIM44 8 GO:0009064 glutamine family amino acid metabolic process 6/896 78/18722 0.169679028765159 0.496558084058969 ARHGAP11B/GMPS/GCLM/PPAT/GFPT1/RIMKLB 6 GO:0019319 hexose biosynthetic process 6/896 78/18722 0.169679028765159 0.496558084058969 SLC35B4/SOGA1/PGP/SLC25A1/RANBP2/DDB1 6 GO:0008585 female gonad development 7/896 95/18722 0.169749223540896 0.496558084058969 BRCA2/NR2F2/ADAMTS1/NUP107/HSPA5/PLEKHA1/ZFX 7 GO:0006221 pyrimidine nucleotide biosynthetic process 3/896 30/18722 0.171583446530234 0.499779971772628 TYMS/DUT/DTYMK 3 GO:0009264 deoxyribonucleotide catabolic process 3/896 30/18722 0.171583446530234 0.499779971772628 DUT/NUDT15/UNG 3 GO:0015865 purine nucleotide transport 3/896 30/18722 0.171583446530234 0.499779971772628 SLC29A1/GJA1/SLC25A5 3 GO:0044030 regulation of DNA methylation 3/896 30/18722 0.171583446530234 0.499779971772628 PARP1/BRCA1/MIS18A 3 GO:0044788 modulation by host of viral process 3/896 30/18722 0.171583446530234 0.499779971772628 NUCKS1/FMR1/HSPA8 3 GO:0090314 positive regulation of protein targeting to membrane 3/896 30/18722 0.171583446530234 0.499779971772628 TCAF1/ANK3/MYO1C 3 GO:2000648 positive regulation of stem cell proliferation 3/896 30/18722 0.171583446530234 0.499779971772628 GJA1/HNRNPU/CCNE1 3 GO:0009913 epidermal cell differentiation 13/896 202/18722 0.171771769326981 0.500023430955491 DSP/EZH2/MCOLN3/ESRP1/EXPH5/ROCK2/YAP1/PALLD/ST14/HDAC2/RBPJ/NCOA3/TRIOBP 13 GO:0048568 embryonic organ development 25/896 427/18722 0.174214115975447 0.500576979032575 FBN2/EFEMP1/FBN1/BMP7/NR2F2/TEAD1/PKD2/DLG1/FZD5/PBX1/FZD6/YAP1/COBL/AHI1/SETD2/SPINT1/BPTF/SPINT2/TRIM28/ST14/SLC39A1/RBPJ/TRA2B/TRIOBP/RAD23B 25 GO:0031124 mRNA 3'-end processing 5/896 62/18722 0.17466428740393 0.500576979032575 CCNB1/APP/SLBP/BARD1/AHCYL1 5 GO:0045428 regulation of nitric oxide biosynthetic process 5/896 62/18722 0.17466428740393 0.500576979032575 HSP90AA1/PKD2/ROCK2/KHSRP/HSP90AB1 5 GO:0060113 inner ear receptor cell differentiation 5/896 62/18722 0.17466428740393 0.500576979032575 MCOLN3/ESRP1/TRIP11/RBPJ/TRIOBP 5 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 5/896 62/18722 0.17466428740393 0.500576979032575 DAG1/CLSTN1/EPS8/DLG1/CTNND1 5 GO:0032869 cellular response to insulin stimulus 13/896 203/18722 0.176060243081747 0.500576979032575 PRKDC/NUCKS1/ATP2B1/PARP1/KANK1/IGF1R/PHIP/SOGA1/PPAT/SMARCC1/SNX5/MYO1C/SRSF5 13 GO:0003073 regulation of systemic arterial blood pressure 7/896 96/18722 0.176108436730526 0.500576979032575 MME/ENPEP/NR2F2/GJA5/GJA1/EMP2/ADRB1 7 GO:0030510 regulation of BMP signaling pathway 7/896 96/18722 0.176108436730526 0.500576979032575 LRP2/FBN1/FSTL1/CRIM1/CTDSPL2/TRIM33/RBPJ 7 GO:0034620 cellular response to unfolded protein 7/896 96/18722 0.176108436730526 0.500576979032575 CCND1/TM7SF3/HSPA5/HSPD1/HSPA9/UFL1/HSPA8 7 GO:0055017 cardiac muscle tissue growth 7/896 96/18722 0.176108436730526 0.500576979032575 CCNB1/CDK1/GJA1/PARP2/YAP1/TGFBR3/RBPJ 7 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/896 16/18722 0.176736744978685 0.500576979032575 MME/ENPEP 2 GO:0005980 glycogen catabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 HMGB1/AGL 2 GO:0006004 fucose metabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 FUT8/FUCA2 2 GO:0006206 pyrimidine nucleobase metabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 TYMS/RRM1 2 GO:0006544 glycine metabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 DHFR/GLDC 2 GO:0006555 methionine metabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 MTR/MTAP 2 GO:0006857 oligopeptide transport 2/896 16/18722 0.176736744978685 0.500576979032575 GJA1/SLC13A3 2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2/896 16/18722 0.176736744978685 0.500576979032575 BRCA2/FOXM1 2 GO:0009048 dosage compensation by inactivation of X chromosome 2/896 16/18722 0.176736744978685 0.500576979032575 BRCA1/HNRNPU 2 GO:0010225 response to UV-C 2/896 16/18722 0.176736744978685 0.500576979032575 BRCA2/HMGN1 2 GO:0016584 nucleosome positioning 2/896 16/18722 0.176736744978685 0.500576979032575 CTCF/SMARCA5 2 GO:0017014 protein nitrosylation 2/896 16/18722 0.176736744978685 0.500576979032575 OXR1/ADH5 2 GO:0018119 peptidyl-cysteine S-nitrosylation 2/896 16/18722 0.176736744978685 0.500576979032575 OXR1/ADH5 2 GO:0019081 viral translation 2/896 16/18722 0.176736744978685 0.500576979032575 EIF3A/DHX9 2 GO:0021535 cell migration in hindbrain 2/896 16/18722 0.176736744978685 0.500576979032575 ITGB1/RERE 2 GO:0021783 preganglionic parasympathetic fiber development 2/896 16/18722 0.176736744978685 0.500576979032575 NRP2/NRP1 2 GO:0030575 nuclear body organization 2/896 16/18722 0.176736744978685 0.500576979032575 SF1/SERBP1 2 GO:0033631 cell-cell adhesion mediated by integrin 2/896 16/18722 0.176736744978685 0.500576979032575 DPP4/ITGB1 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/896 16/18722 0.176736744978685 0.500576979032575 BMP7/GCNT2 2 GO:0043923 positive regulation by host of viral transcription 2/896 16/18722 0.176736744978685 0.500576979032575 NUCKS1/SMARCA4 2 GO:0045721 negative regulation of gluconeogenesis 2/896 16/18722 0.176736744978685 0.500576979032575 SOGA1/PGP 2 GO:0046037 GMP metabolic process 2/896 16/18722 0.176736744978685 0.500576979032575 GMPS/DLG1 2 GO:0061548 ganglion development 2/896 16/18722 0.176736744978685 0.500576979032575 NRP2/NRP1 2 GO:0061684 chaperone-mediated autophagy 2/896 16/18722 0.176736744978685 0.500576979032575 HSP90AA1/HSPA8 2 GO:0090336 positive regulation of brown fat cell differentiation 2/896 16/18722 0.176736744978685 0.500576979032575 BMP7/HNRNPU 2 GO:0097202 activation of cysteine-type endopeptidase activity 2/896 16/18722 0.176736744978685 0.500576979032575 PERP/ASPH 2 GO:0099633 protein localization to postsynaptic specialization membrane 2/896 16/18722 0.176736744978685 0.500576979032575 DAG1/DLG1 2 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 2/896 16/18722 0.176736744978685 0.500576979032575 DAG1/DLG1 2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 2/896 16/18722 0.176736744978685 0.500576979032575 ANK3/KIF5B 2 GO:2000765 regulation of cytoplasmic translation 2/896 16/18722 0.176736744978685 0.500576979032575 DHX9/FMR1 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/896 16/18722 0.176736744978685 0.500576979032575 PRKDC/RIF1 2 GO:2001224 positive regulation of neuron migration 2/896 16/18722 0.176736744978685 0.500576979032575 KIF20B/SEMA6A 2 GO:0006446 regulation of translational initiation 6/896 79/18722 0.176752592571099 0.500576979032575 TPR/AGO2/KHDRBS1/LARP1/EIF4G1/FMR1 6 GO:0042398 cellular modified amino acid biosynthetic process 4/896 46/18722 0.176785250659598 0.500576979032575 DHFR/PLOD2/GCLM/ALDH7A1 4 GO:0061028 establishment of endothelial barrier 4/896 46/18722 0.176785250659598 0.500576979032575 ROCK2/MARVELD2/RDX/VCL 4 GO:0061462 protein localization to lysosome 4/896 46/18722 0.176785250659598 0.500576979032575 ROCK2/NEDD4/HSPA8/RTN4 4 GO:0034767 positive regulation of ion transmembrane transport 11/896 167/18722 0.177496067495261 0.502291776065427 TCAF1/ITGB1/ANK3/PKD2/ALG10B/CALM2/ARL6IP1/AKAP9/KIF5B/ATP1B3/ANO6 11 GO:0018105 peptidyl-serine phosphorylation 19/896 315/18722 0.178876243609255 0.505897622624752 CCNB1/CDK1/PRKDC/EGFR/AURKA/APP/CLSPN/HSP90AA1/AURKB/TTK/PLK1/VRK1/MASTL/ROCK2/PKN2/CDK2/AKAP9/EIF4G1/HSP90AB1 19 GO:0046660 female sex differentiation 8/896 114/18722 0.179811546850755 0.508241755278571 LRP2/BRCA2/NR2F2/ADAMTS1/NUP107/HSPA5/PLEKHA1/ZFX 8 GO:0031346 positive regulation of cell projection organization 21/896 353/18722 0.17998389995237 0.508427892528174 ITGA6/ANLN/TENM3/EZH2/BMP7/NRP1/EPS8/CCP110/CEP135/COBL/VLDLR/PPP1R9A/PLXNB1/GOLGA4/IQGAP1/MACF1/HSPA5/ATMIN/FMR1/LRP1/SERPINF1 21 GO:0008217 regulation of blood pressure 12/896 186/18722 0.181588096326212 0.51265616313503 ATP2B1/MME/ENPEP/NR2F2/GJA5/GJA1/ATP1A1/LRP5/EMP2/ADRB1/SNX5/ADH5 12 GO:0070167 regulation of biomineral tissue development 7/896 97/18722 0.1825678441163 0.515117545987716 FBN2/ATP2B1/BMP7/FBXO5/ROCK2/ANKH/ANO6 7 GO:0006613 cotranslational protein targeting to membrane 3/896 31/18722 0.183665093505404 0.515774797879293 ARL6IP1/TRAM2/SEC63 3 GO:0007190 activation of adenylate cyclase activity 3/896 31/18722 0.183665093505404 0.515774797879293 LGR5/ADRB1/LGR4 3 GO:0031114 regulation of microtubule depolymerization 3/896 31/18722 0.183665093505404 0.515774797879293 TPX2/CKAP2/CAMSAP2 3 GO:0035510 DNA dealkylation 3/896 31/18722 0.183665093505404 0.515774797879293 ASCC3/TRIM28/USP9X 3 GO:0036475 neuron death in response to oxidative stress 3/896 31/18722 0.183665093505404 0.515774797879293 PARP1/OXR1/NONO 3 GO:0046386 deoxyribose phosphate catabolic process 3/896 31/18722 0.183665093505404 0.515774797879293 DUT/NUDT15/UNG 3 GO:0060390 regulation of SMAD protein signal transduction 3/896 31/18722 0.183665093505404 0.515774797879293 PARP1/SPTBN1/LRP1 3 GO:0090183 regulation of kidney development 3/896 31/18722 0.183665093505404 0.515774797879293 LGR4/TACSTD2/MAGED1 3 GO:1901264 carbohydrate derivative transport 6/896 80/18722 0.183943597731722 0.516253224909605 SLC29A1/GJA1/SLC35B4/VLDLR/SLC35D1/SLC25A5 6 GO:0007595 lactation 4/896 47/18722 0.186455412617215 0.520244383304841 SLC29A1/CCND1/PPAT/PRLR 4 GO:0016574 histone ubiquitination 4/896 47/18722 0.186455412617215 0.520244383304841 RNF168/USP22/HUWE1/DDB1 4 GO:0035315 hair cell differentiation 4/896 47/18722 0.186455412617215 0.520244383304841 MCOLN3/ESRP1/RBPJ/TRIOBP 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/896 47/18722 0.186455412617215 0.520244383304841 YAP1/ASXL1/IQGAP1/CD24 4 GO:0042311 vasodilation 4/896 47/18722 0.186455412617215 0.520244383304841 EGFR/GJA5/GJA1/ADRB1 4 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 4/896 47/18722 0.186455412617215 0.520244383304841 CHEK1/NEDD4/HSPA5/RBPJ 4 GO:0045601 regulation of endothelial cell differentiation 4/896 47/18722 0.186455412617215 0.520244383304841 APOLD1/ROCK2/VCL/ID1 4 GO:0045646 regulation of erythrocyte differentiation 4/896 47/18722 0.186455412617215 0.520244383304841 HMGB2/PRKDC/CDK6/HSPA9 4 GO:0048483 autonomic nervous system development 4/896 47/18722 0.186455412617215 0.520244383304841 NRP2/NRP1/SOX4/NF1 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/896 47/18722 0.186455412617215 0.520244383304841 LGR4/ID1/RBPJ/RHEB 4 GO:2001234 negative regulation of apoptotic signaling pathway 14/896 224/18722 0.187292431636081 0.522274572798276 HMGB2/HELLS/ITGA6/ITGAV/BRCA1/NRP1/PHIP/RTKN2/FIGNL1/GCLM/YAP1/USP47/NONO/SLC25A5 14 GO:0071333 cellular response to glucose stimulus 10/896 151/18722 0.187654717378329 0.522674224483163 SLC29A1/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 10 GO:2001236 regulation of extrinsic apoptotic signaling pathway 10/896 151/18722 0.187654717378329 0.522674224483163 HMGB2/ITGA6/ITGAV/BRCA1/NRP1/PHIP/GCLM/YAP1/BCL2L12/PDIA3 10 GO:0003333 amino acid transmembrane transport 7/896 98/18722 0.18912450038371 0.526460854129347 ITGB1/SLC38A1/SFXN1/ARL6IP1/SLC38A2/SLC1A5/SLC7A6 7 GO:0008016 regulation of heart contraction 13/896 206/18722 0.189235362697448 0.526462483401874 DSP/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/NUP155/ADRB1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 13 GO:0009636 response to toxic substance 16/896 262/18722 0.190690224306154 0.526746414403134 TYMS/CCNB1/CDK1/CDH1/BMP7/DHFR/GPX8/RAD51/MT2A/SLC6A4/PPP1R9A/DNMT3A/PON2/DHX15/PRDX4/ADH5 16 GO:0010466 negative regulation of peptidase activity 16/896 262/18722 0.190690224306154 0.526746414403134 PTTG1/BIRC5/APLP2/ITIH5/APP/DHCR24/CRIM1/ARL6IP1/BCL2L12/SPINT1/SPINT2/LRP1/SERPINH1/USP14/USP47/SERPINF1 16 GO:0031330 negative regulation of cellular catabolic process 16/896 262/18722 0.190690224306154 0.526746414403134 FUS/MET/PBK/SMARCC1/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/EIF4G1/FMR1/USP14/THRAP3/HSP90AB1 16 GO:0048839 inner ear development 12/896 188/18722 0.190897551181842 0.526746414403134 CCNA2/LGR5/MCOLN3/ESRP1/MCM2/FREM2/FZD6/AHI1/TRIP11/ANP32B/RBPJ/TRIOBP 12 GO:0001885 endothelial cell development 5/896 64/18722 0.191101830152704 0.526746414403134 MET/ROCK2/MARVELD2/RDX/VCL 5 GO:0045995 regulation of embryonic development 5/896 64/18722 0.191101830152704 0.526746414403134 CDK1/DAG1/LAMA5/RACGAP1/AMOT 5 GO:0048857 neural nucleus development 5/896 64/18722 0.191101830152704 0.526746414403134 CCDC14/NFIB/YWHAH/CALM2/HSPA5 5 GO:0050771 negative regulation of axonogenesis 5/896 64/18722 0.191101830152704 0.526746414403134 NRP1/SEMA6D/SEMA6A/RYK/RTN4 5 GO:0080164 regulation of nitric oxide metabolic process 5/896 64/18722 0.191101830152704 0.526746414403134 HSP90AA1/PKD2/ROCK2/KHSRP/HSP90AB1 5 GO:1900076 regulation of cellular response to insulin stimulus 5/896 64/18722 0.191101830152704 0.526746414403134 NUCKS1/ATP2B1/KANK1/SNX5/MYO1C 5 GO:0046209 nitric oxide metabolic process 6/896 81/18722 0.191247805355302 0.526746414403134 HSP90AA1/PKD2/ROCK2/CYB5B/KHSRP/HSP90AB1 6 GO:0051817 modulation of process of other organism involved in symbiotic interaction 6/896 81/18722 0.191247805355302 0.526746414403134 NUCKS1/DAG1/SMARCA4/FMR1/ANO6/HSPA8 6 GO:0008037 cell recognition 14/896 225/18722 0.191567456733044 0.526746414403134 COLEC12/APP/CADM1/NRP1/CNTNAP2/DLG1/NRCAM/PALLD/SPESP1/CCT5/CCT2/CCT4/RTN4/BSG 14 GO:0030326 embryonic limb morphogenesis 8/896 116/18722 0.191818664159898 0.526746414403134 FBN2/BMP7/LRP5/FRAS1/FREM2/PBX1/FZD6/HDAC2 8 GO:0031123 RNA 3'-end processing 8/896 116/18722 0.191818664159898 0.526746414403134 CCNB1/APP/SLBP/BARD1/EXOSC8/LIN28B/AHCYL1/RPS21 8 GO:0035113 embryonic appendage morphogenesis 8/896 116/18722 0.191818664159898 0.526746414403134 FBN2/BMP7/LRP5/FRAS1/FREM2/PBX1/FZD6/HDAC2 8 GO:0043200 response to amino acid 8/896 116/18722 0.191818664159898 0.526746414403134 PCNA/IPO5/GCLM/DNMT1/COL5A2/HNRNPD/DNMT3A/UFL1 8 GO:0030509 BMP signaling pathway 10/896 152/18722 0.192917052530575 0.526746414403134 LRP2/FBN1/BMP7/FSTL1/CRIM1/CTDSPL2/TRIM33/TGFBR3/USP9X/RBPJ 10 GO:0000097 sulfur amino acid biosynthetic process 2/896 17/18722 0.194302563000402 0.526746414403134 MTR/MTAP 2 GO:0001829 trophectodermal cell differentiation 2/896 17/18722 0.194302563000402 0.526746414403134 YAP1/CNOT1 2 GO:0008334 histone mRNA metabolic process 2/896 17/18722 0.194302563000402 0.526746414403134 SLBP/DCP2 2 GO:0009251 glucan catabolic process 2/896 17/18722 0.194302563000402 0.526746414403134 HMGB1/AGL 2 GO:0010715 regulation of extracellular matrix disassembly 2/896 17/18722 0.194302563000402 0.526746414403134 DPP4/LRP1 2 GO:0015867 ATP transport 2/896 17/18722 0.194302563000402 0.526746414403134 GJA1/SLC25A5 2 GO:0021924 cell proliferation in external granule layer 2/896 17/18722 0.194302563000402 0.526746414403134 SLC6A4/RERE 2 GO:0021930 cerebellar granule cell precursor proliferation 2/896 17/18722 0.194302563000402 0.526746414403134 SLC6A4/RERE 2 GO:0030903 notochord development 2/896 17/18722 0.194302563000402 0.526746414403134 YAP1/COBL 2 GO:0033623 regulation of integrin activation 2/896 17/18722 0.194302563000402 0.526746414403134 KIF14/FERMT1 2 GO:0035518 histone H2A monoubiquitination 2/896 17/18722 0.194302563000402 0.526746414403134 RNF168/DDB1 2 GO:0035729 cellular response to hepatocyte growth factor stimulus 2/896 17/18722 0.194302563000402 0.526746414403134 NRP1/GCLM 2 GO:0042772 DNA damage response, signal transduction resulting in transcription 2/896 17/18722 0.194302563000402 0.526746414403134 BRCA2/FOXM1 2 GO:0043968 histone H2A acetylation 2/896 17/18722 0.194302563000402 0.526746414403134 YEATS4/BRD8 2 GO:0044539 long-chain fatty acid import into cell 2/896 17/18722 0.194302563000402 0.526746414403134 SLC27A2/SLC2A1 2 GO:0045815 positive regulation of gene expression, epigenetic 2/896 17/18722 0.194302563000402 0.526746414403134 CDCA4/CHEK1 2 GO:0055119 relaxation of cardiac muscle 2/896 17/18722 0.194302563000402 0.526746414403134 ATP1A1/ATP2A2 2 GO:0061158 3'-UTR-mediated mRNA destabilization 2/896 17/18722 0.194302563000402 0.526746414403134 HNRNPD/KHSRP 2 GO:0061298 retina vasculature development in camera-type eye 2/896 17/18722 0.194302563000402 0.526746414403134 NRP1/LRP5 2 GO:0061952 midbody abscission 2/896 17/18722 0.194302563000402 0.526746414403134 CEP55/KIF20A 2 GO:0070593 dendrite self-avoidance 2/896 17/18722 0.194302563000402 0.526746414403134 PALLD/BSG 2 GO:0071371 cellular response to gonadotropin stimulus 2/896 17/18722 0.194302563000402 0.526746414403134 CCNA2/GCLM 2 GO:0140354 lipid import into cell 2/896 17/18722 0.194302563000402 0.526746414403134 SLC27A2/SLC2A1 2 GO:1901550 regulation of endothelial cell development 2/896 17/18722 0.194302563000402 0.526746414403134 ROCK2/VCL 2 GO:1903140 regulation of establishment of endothelial barrier 2/896 17/18722 0.194302563000402 0.526746414403134 ROCK2/VCL 2 GO:1903358 regulation of Golgi organization 2/896 17/18722 0.194302563000402 0.526746414403134 CAMSAP2/AKAP9 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/896 17/18722 0.194302563000402 0.526746414403134 YAP1/CD24 2 GO:0042391 regulation of membrane potential 25/896 434/18722 0.195323094971971 0.52794125395136 DSP/DSG2/APP/PARP1/SLC29A1/GJA5/GJA1/ATP1A1/ANK3/NUP155/ADRB1/DLG1/YWHAH/GABRE/ATP2A2/GCLM/DSC2/PPP1R9A/SLC25A36/NEDD4/USP53/AKAP9/KIF5B/FMR1/ATP1B3 25 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 7/896 99/18722 0.195775377053158 0.52794125395136 BRCA2/PRKDC/BRCA1/MSH6/MSH2/TMEM109/USP47 7 GO:0110149 regulation of biomineralization 7/896 99/18722 0.195775377053158 0.52794125395136 FBN2/ATP2B1/BMP7/FBXO5/ROCK2/ANKH/ANO6 7 GO:0003338 metanephros morphogenesis 3/896 32/18722 0.195962923991377 0.52794125395136 FRAS1/PKD2/LGR4 3 GO:0021799 cerebral cortex radially oriented cell migration 3/896 32/18722 0.195962923991377 0.52794125395136 LAMB1/ADGRG1/RTN4 3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 3/896 32/18722 0.195962923991377 0.52794125395136 FERMT1/TGFBR3/HSP90AB1 3 GO:0035767 endothelial cell chemotaxis 3/896 32/18722 0.195962923991377 0.52794125395136 HMGB1/MET/NRP1 3 GO:0060317 cardiac epithelial to mesenchymal transition 3/896 32/18722 0.195962923991377 0.52794125395136 TGFBR3/RBPJ/RTN4 3 GO:0060323 head morphogenesis 3/896 32/18722 0.195962923991377 0.52794125395136 CRISPLD1/ANKRD11/PLEKHA1 3 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 3/896 32/18722 0.195962923991377 0.52794125395136 FERMT1/TGFBR3/HSP90AB1 3 GO:1905476 negative regulation of protein localization to membrane 3/896 32/18722 0.195962923991377 0.52794125395136 GOPC/PPFIA1/CLTC 3 GO:0015804 neutral amino acid transport 4/896 48/18722 0.19629152194463 0.52794125395136 SLC38A1/SFXN1/SLC38A2/SLC1A5 4 GO:0035036 sperm-egg recognition 4/896 48/18722 0.19629152194463 0.52794125395136 SPESP1/CCT5/CCT2/CCT4 4 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 4/896 48/18722 0.19629152194463 0.52794125395136 PBK/SMARCC1/USP14/HSP90AB1 4 GO:0071496 cellular response to external stimulus 19/896 320/18722 0.196656101960321 0.528624003805503 EGFR/ATP2B1/DAG1/GJA1/CTSV/CHEK1/ATP1A1/CASP8AP2/NUDT15/SKP2/SLC38A2/TRIM24/TNRC6A/HSPA5/STK24/TMEM150C/EIF4G1/SLC2A1/HSPA8 19 GO:0048469 cell maturation 11/896 171/18722 0.197185618964959 0.529749096757858 TYMS/CCNB1/BRCA2/AURKA/APP/FBXO5/KIF14/CNTNAP2/FZD5/NRCAM/TFCP2L1 11 GO:0071331 cellular response to hexose stimulus 10/896 153/18722 0.198243708613404 0.531916446011 SLC29A1/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 10 GO:0001101 response to acid chemical 9/896 135/18722 0.198601428662363 0.531916446011 PCNA/IPO5/PKD2/GCLM/DNMT1/COL5A2/HNRNPD/DNMT3A/UFL1 9 GO:0002312 B cell activation involved in immune response 6/896 82/18722 0.198660876254213 0.531916446011 RIF1/MSH6/MSH2/RNF168/UNG/HSPD1 6 GO:0046364 monosaccharide biosynthetic process 6/896 82/18722 0.198660876254213 0.531916446011 SLC35B4/SOGA1/PGP/SLC25A1/RANBP2/DDB1 6 GO:0072527 pyrimidine-containing compound metabolic process 6/896 82/18722 0.198660876254213 0.531916446011 TYMS/RRM1/DUT/TK1/DTYMK/UNG 6 GO:2001057 reactive nitrogen species metabolic process 6/896 82/18722 0.198660876254213 0.531916446011 HSP90AA1/PKD2/ROCK2/CYB5B/KHSRP/HSP90AB1 6 GO:0035418 protein localization to synapse 5/896 65/18722 0.199519442367919 0.533317927135747 DAG1/CLSTN1/DLG1/ZDHHC12/KIF5B 5 GO:1902475 L-alpha-amino acid transmembrane transport 5/896 65/18722 0.199519442367919 0.533317927135747 ITGB1/SLC38A1/ARL6IP1/SLC1A5/SLC7A6 5 GO:1905330 regulation of morphogenesis of an epithelium 5/896 65/18722 0.199519442367919 0.533317927135747 BMP7/GJA1/LGR4/TACSTD2/MAGED1 5 GO:0098657 import into cell 14/896 227/18722 0.200254200867654 0.534982403437147 LRP2/SLC27A2/SLC29A1/SLC39A10/ITGB1/SLC38A1/ATP1A1/DLG1/SLC6A4/SLC5A3/ARL6IP1/SLC1A5/ATP1B3/SLC2A1 14 GO:0007389 pattern specification process 25/896 436/18722 0.201583458068474 0.538232342739875 LRP2/PRKDC/AURKA/GALNT11/NRP2/WLS/ADGRG1/BMP7/NRP1/NR2F2/PGAP1/LRP5/XRCC2/MEIS2/PKD2/FZD5/PBX1/COBL/MTF2/IRX2/AHI1/BPTF/HSPB11/RBPJ/TRA2B 25 GO:0001678 cellular glucose homeostasis 11/896 172/18722 0.202254252851895 0.539721522143626 NUCKS1/SLC29A1/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 11 GO:0006626 protein targeting to mitochondrion 7/896 100/18722 0.202517368565991 0.539820166127327 HSP90AA1/LMAN1/FZD5/SAE1/NPEPPS/HUWE1/HSPD1 7 GO:0046545 development of primary female sexual characteristics 7/896 100/18722 0.202517368565991 0.539820166127327 BRCA2/NR2F2/ADAMTS1/NUP107/HSPA5/PLEKHA1/ZFX 7 GO:0071326 cellular response to monosaccharide stimulus 10/896 154/18722 0.203633240264662 0.542491679142576 SLC29A1/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 10 GO:0043010 camera-type eye development 19/896 322/18722 0.204001564910127 0.543169810865001 FBN2/RRM1/EFEMP1/FBN1/ATP2B1/TENM3/BMP7/NRP1/FAT1/LRP5/DLG1/FZD5/NF1/PTPRM/AHI1/SMARCA4/HDAC2/SERPINF1/HMGN1 19 GO:0045727 positive regulation of translation 9/896 136/18722 0.204364305220357 0.543832326154953 PRKDC/SOX4/AGO2/HNRNPD/DHX9/KHDRBS1/LARP1/EIF4G1/FMR1 9 GO:0009409 response to cold 4/896 49/18722 0.206282208235593 0.545288627971606 ATP2B1/HSP90AA1/ADRB1/HSPD1 4 GO:0014075 response to amine 4/896 49/18722 0.206282208235593 0.545288627971606 CDK1/GLDC/RANBP2/HDAC2 4 GO:0021695 cerebellar cortex development 4/896 49/18722 0.206282208235593 0.545288627971606 EZH2/KIF14/RERE/HSPA5 4 GO:0030857 negative regulation of epithelial cell differentiation 4/896 49/18722 0.206282208235593 0.545288627971606 EZH2/CCND1/YAP1/ID1 4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 4/896 49/18722 0.206282208235593 0.545288627971606 KIF14/CCNF/SKP2/CUL1 4 GO:0035088 establishment or maintenance of apical/basal cell polarity 4/896 49/18722 0.206282208235593 0.545288627971606 FAT1/PARD3/DLG1/DLG5 4 GO:0038084 vascular endothelial growth factor signaling pathway 4/896 49/18722 0.206282208235593 0.545288627971606 NRP2/NRP1/SEMA6A/MYO1C 4 GO:0045778 positive regulation of ossification 4/896 49/18722 0.206282208235593 0.545288627971606 FBN2/ATP2B1/BMP7/ANO6 4 GO:0052372 modulation by symbiont of entry into host 4/896 49/18722 0.206282208235593 0.545288627971606 ITGAV/P4HB/LY6E/FUCA2 4 GO:0061245 establishment or maintenance of bipolar cell polarity 4/896 49/18722 0.206282208235593 0.545288627971606 FAT1/PARD3/DLG1/DLG5 4 GO:0086009 membrane repolarization 4/896 49/18722 0.206282208235593 0.545288627971606 GJA5/ATP1A1/AKAP9/ATP1B3 4 GO:1901799 negative regulation of proteasomal protein catabolic process 4/896 49/18722 0.206282208235593 0.545288627971606 PBK/SMARCC1/USP14/HSP90AB1 4 GO:0050918 positive chemotaxis 5/896 66/18722 0.208060669727761 0.549077743106873 HMGB2/HMGB1/MET/NRP1/LRP1 5 GO:0050922 negative regulation of chemotaxis 5/896 66/18722 0.208060669727761 0.549077743106873 DPP4/NRP1/SEMA6D/SEMA6A/RYK 5 GO:0071300 cellular response to retinoic acid 5/896 66/18722 0.208060669727761 0.549077743106873 SLC6A4/YAP1/YES1/HDAC2/SERPINF1 5 GO:0009156 ribonucleoside monophosphate biosynthetic process 3/896 33/18722 0.208453852568305 0.549204576247842 GMPS/PPAT/PAICS 3 GO:0048333 mesodermal cell differentiation 3/896 33/18722 0.208453852568305 0.549204576247842 ITGB1/ITGB4/GJA1 3 GO:0071763 nuclear membrane organization 3/896 33/18722 0.208453852568305 0.549204576247842 PLK1/VRK1/ANKLE2 3 GO:0055123 digestive system development 9/896 137/18722 0.210195144250403 0.55171211334448 TYMS/CCNB1/EGFR/WLS/KLF5/YAP1/COBL/LGR4/AHI1 9 GO:0003128 heart field specification 2/896 18/18722 0.212074219447013 0.55171211334448 LRP2/RBPJ 2 GO:0007549 dosage compensation 2/896 18/18722 0.212074219447013 0.55171211334448 BRCA1/HNRNPU 2 GO:0008272 sulfate transport 2/896 18/18722 0.212074219447013 0.55171211334448 RACGAP1/SLC26A2 2 GO:0010985 negative regulation of lipoprotein particle clearance 2/896 18/18722 0.212074219447013 0.55171211334448 KHSRP/LRPAP1 2 GO:0021534 cell proliferation in hindbrain 2/896 18/18722 0.212074219447013 0.55171211334448 SLC6A4/RERE 2 GO:0033189 response to vitamin A 2/896 18/18722 0.212074219447013 0.55171211334448 TYMS/DNMT3A 2 GO:0034162 toll-like receptor 9 signaling pathway 2/896 18/18722 0.212074219447013 0.55171211334448 HMGB1/RTN4 2 GO:0035372 protein localization to microtubule 2/896 18/18722 0.212074219447013 0.55171211334448 KIF20B/HNRNPU 2 GO:0043217 myelin maintenance 2/896 18/18722 0.212074219447013 0.55171211334448 DEGS1/EPB41L3 2 GO:0044247 cellular polysaccharide catabolic process 2/896 18/18722 0.212074219447013 0.55171211334448 HMGB1/AGL 2 GO:0046040 IMP metabolic process 2/896 18/18722 0.212074219447013 0.55171211334448 PPAT/PAICS 2 GO:0048486 parasympathetic nervous system development 2/896 18/18722 0.212074219447013 0.55171211334448 NRP2/NRP1 2 GO:0051447 negative regulation of meiotic cell cycle 2/896 18/18722 0.212074219447013 0.55171211334448 TTK/FBXO5 2 GO:0055070 copper ion homeostasis 2/896 18/18722 0.212074219447013 0.55171211334448 APP/MT2A 2 GO:0060008 Sertoli cell differentiation 2/896 18/18722 0.212074219447013 0.55171211334448 CTSV/ATRX 2 GO:0060716 labyrinthine layer blood vessel development 2/896 18/18722 0.212074219447013 0.55171211334448 FZD5/RBPJ 2 GO:0071360 cellular response to exogenous dsRNA 2/896 18/18722 0.212074219447013 0.55171211334448 COLEC12/DHX9 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/896 18/18722 0.212074219447013 0.55171211334448 LGR4/MAGED1 2 GO:0110154 RNA decapping 2/896 18/18722 0.212074219447013 0.55171211334448 DCP2/PNRC2 2 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/896 18/18722 0.212074219447013 0.55171211334448 AGO2/CNOT1 2 GO:1902074 response to salt 2/896 18/18722 0.212074219447013 0.55171211334448 HNRNPD/HSPA5 2 GO:1903209 positive regulation of oxidative stress-induced cell death 2/896 18/18722 0.212074219447013 0.55171211334448 PAWR/SFPQ 2 GO:0043491 protein kinase B signaling 13/896 211/18722 0.212179187285393 0.55171211334448 LRP2/MET/EGFR/DAG1/HSP90AA1/ITGB1/TPBG/IGF1R/DLG1/GCNT2/PLEKHA1/RTN4/HSP90AB1 13 GO:0048639 positive regulation of developmental growth 11/896 174/18722 0.212558677969522 0.552398001429775 CCNB1/CDK1/PRKDC/NRP1/PARP2/YAP1/GOLGA4/MACF1/TGFBR3/LRP1/RBPJ 11 GO:0010921 regulation of phosphatase activity 6/896 84/18722 0.213795811846302 0.555310775709599 HSP90B1/SLC39A10/MASTL/CALM2/ROCK2/HSP90AB1 6 GO:0001764 neuron migration 10/896 156/18722 0.214594953632987 0.557083365222338 ASPM/KIF20B/NRP2/ADGRG1/NRP1/NR2F2/SEMA6A/NRCAM/PCM1/USP9X 10 GO:0050708 regulation of protein secretion 16/896 268/18722 0.215165508696584 0.558260944846462 MYH10/EGFR/WLS/DPP4/GJA1/LRP5/EXPH5/SOX4/SLC16A1/FRMD4A/TM7SF3/KIF5B/CD2AP/LRP1/IDH2/ERP29 16 GO:0032273 positive regulation of protein polymerization 9/896 138/18722 0.216092041145275 0.558826066612792 MET/IQGAP2/HSP90AA1/CKAP5/CDK5RAP2/DLG1/MYO1C/CLIP1/AKAP9 9 GO:0006220 pyrimidine nucleotide metabolic process 4/896 50/18722 0.216416085857131 0.558826066612792 TYMS/DUT/DTYMK/UNG 4 GO:0007140 male meiotic nuclear division 4/896 50/18722 0.216416085857131 0.558826066612792 BRCA2/RAD51C/KIF18A/FIGNL1 4 GO:0007632 visual behavior 4/896 50/18722 0.216416085857131 0.558826066612792 APP/ITGB1/MEIS2/NF1 4 GO:0060425 lung morphogenesis 4/896 50/18722 0.216416085857131 0.558826066612792 DAG1/NFIB/YAP1/DLG5 4 GO:0071709 membrane assembly 4/896 50/18722 0.216416085857131 0.558826066612792 SPTBN1/ANK3/EMP2/ANKLE2 4 GO:0042490 mechanoreceptor differentiation 5/896 67/18722 0.216718702140703 0.558826066612792 MCOLN3/ESRP1/TRIP11/RBPJ/TRIOBP 5 GO:0061077 chaperone-mediated protein folding 5/896 67/18722 0.216718702140703 0.558826066612792 PDIA4/HSPA5/HSPA9/HSPA8/CCT2 5 GO:0072665 protein localization to vacuole 5/896 67/18722 0.216718702140703 0.558826066612792 ROCK2/VPS13A/NEDD4/HSPA8/RTN4 5 GO:0030218 erythrocyte differentiation 8/896 120/18722 0.216787992326538 0.558826066612792 HMGB2/PRKDC/NCAPG2/CDK6/TGFBR3/HSPA9/UFL1/SLC25A5 8 GO:0032411 positive regulation of transporter activity 8/896 120/18722 0.216787992326538 0.558826066612792 TCAF1/ANK3/PKD2/ALG10B/CALM2/AKAP9/KIF5B/ATP1B3 8 GO:0071901 negative regulation of protein serine/threonine kinase activity 8/896 120/18722 0.216787992326538 0.558826066612792 BMP7/IPO7/NR2F2/PLK1/LRP5/IPO5/NF1/CDKN2A 8 GO:0042060 wound healing 24/896 422/18722 0.218758008505794 0.563599963630146 HMGB1/F5/DSP/EGFR/DAG1/LMAN1/ITGB1/GJA1/DST/KANK1/DCBLD2/NF1/DGKD/FZD6/FERMT1/YAP1/FBLN1/VCL/VKORC1/MACF1/HPS5/ANO6/MYOF/CLDN4 24 GO:0002262 myeloid cell homeostasis 10/896 157/18722 0.220164054853637 0.565401411331758 HMGB2/HMGB1/PRKDC/NCAPG2/CDK6/TGFBR3/HSPA9/UFL1/RPS17/SLC25A5 10 GO:0007030 Golgi organization 10/896 157/18722 0.220164054853637 0.565401411331758 CDK1/LMAN1/ARHGAP21/VRK1/GOLGB1/CAMSAP2/AKAP9/HUWE1/TRIP11/TMED4 10 GO:0000038 very long-chain fatty acid metabolic process 3/896 34/18722 0.221115298482696 0.565401411331758 SLC27A2/HACD3/TECR 3 GO:0000096 sulfur amino acid metabolic process 3/896 34/18722 0.221115298482696 0.565401411331758 MTR/GCLM/MTAP 3 GO:0001662 behavioral fear response 3/896 34/18722 0.221115298482696 0.565401411331758 DPP4/GJA1/EIF4G1 3 GO:0006356 regulation of transcription by RNA polymerase I 3/896 34/18722 0.221115298482696 0.565401411331758 SMARCA4/NCL/POLR2L 3 GO:0009303 rRNA transcription 3/896 34/18722 0.221115298482696 0.565401411331758 TCOF1/SMARCA4/NCL 3 GO:0010922 positive regulation of phosphatase activity 3/896 34/18722 0.221115298482696 0.565401411331758 SLC39A10/CALM2/HSP90AB1 3 GO:0019320 hexose catabolic process 3/896 34/18722 0.221115298482696 0.565401411331758 LRP5/FUT8/GLB1 3 GO:0035909 aorta morphogenesis 3/896 34/18722 0.221115298482696 0.565401411331758 SOX4/LRP1/RBPJ 3 GO:0048854 brain morphogenesis 3/896 34/18722 0.221115298482696 0.565401411331758 SLC6A4/NF1/FZD6 3 GO:0051085 chaperone cofactor-dependent protein refolding 3/896 34/18722 0.221115298482696 0.565401411331758 HSPA5/HSPA9/HSPA8 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/896 34/18722 0.221115298482696 0.565401411331758 GJA5/GJA1/NUP155 3 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/896 34/18722 0.221115298482696 0.565401411331758 BRCA1/SOX4/BRD7 3 GO:0060021 roof of mouth development 6/896 85/18722 0.221508589445744 0.565800966299616 ITGB8/FRAS1/DLG1/TGFBR3/PLEKHA1/ANP32B 6 GO:0071277 cellular response to calcium ion 6/896 85/18722 0.221508589445744 0.565800966299616 FUS/ECT2/PKD2/IQGAP1/HSPA5/CACYBP 6 GO:0002027 regulation of heart rate 7/896 103/18722 0.223257947833982 0.569964407999695 DSP/DSG2/ADRB1/CALM2/ATP2A2/DSC2/AKAP9 7 GO:0009988 cell-cell recognition 5/896 68/18722 0.225486670455503 0.574558429640367 DLG1/SPESP1/CCT5/CCT2/CCT4 5 GO:0009948 anterior/posterior axis specification 4/896 51/18722 0.22668178943143 0.574558429640367 AURKA/WLS/PGAP1/FZD5 4 GO:0032873 negative regulation of stress-activated MAPK cascade 4/896 51/18722 0.22668178943143 0.574558429640367 PBK/MARVELD3/FOXM1/DLG1 4 GO:0032964 collagen biosynthetic process 4/896 51/18722 0.22668178943143 0.574558429640367 SUCO/TRAM2/HDAC2/SERPINH1 4 GO:0065002 intracellular protein transmembrane transport 4/896 51/18722 0.22668178943143 0.574558429640367 TRAM2/SEC63/HSPA5/HSPD1 4 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 4/896 51/18722 0.22668178943143 0.574558429640367 PBK/MARVELD3/FOXM1/DLG1 4 GO:0010951 negative regulation of endopeptidase activity 15/896 252/18722 0.227796373657398 0.574558429640367 PTTG1/BIRC5/APLP2/ITIH5/APP/DHCR24/CRIM1/ARL6IP1/BCL2L12/SPINT1/SPINT2/SERPINH1/USP14/USP47/SERPINF1 15 GO:0090257 regulation of muscle system process 15/896 252/18722 0.227796373657398 0.574558429640367 DSP/ATP2B1/DSG2/DAG1/PARP1/GJA5/ATP1A1/PARP2/DLG1/CALM2/ATP2A2/DSC2/ROCK2/AKAP9/CAMK2G 15 GO:0030324 lung development 11/896 177/18722 0.228414146668945 0.574558429640367 HMGB1/EGFR/MME/DAG1/LAMA5/NFIB/YAP1/DLG5/ASXL1/HSPB11/RBPJ 11 GO:0071453 cellular response to oxygen levels 11/896 177/18722 0.228414146668945 0.574558429640367 CCNB1/CCNA2/HP1BP3/BMP7/SLC29A1/ROCK2/DNMT3A/P4HB/NPEPPS/HILPDA/RBPJ 11 GO:0032413 negative regulation of ion transmembrane transporter activity 6/896 86/18722 0.229312076088491 0.574558429640367 ANK3/PKD2/CALM2/NEDD4/GOPC/FMR1 6 GO:0043087 regulation of GTPase activity 20/896 348/18722 0.229867719422028 0.574558429640367 STMN1/ITGA6/MET/ECT2/EZH2/IQGAP2/ARHGAP11A/ITGB1/AMOT/SYDE2/ADRB1/NF1/DOCK9/RDX/PLXNB1/NET1/IQGAP1/ASAP1/RASA1/TGM2 20 GO:0000028 ribosomal small subunit assembly 2/896 19/18722 0.229991864064252 0.574558429640367 PRKDC/XRCC5 2 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 2/896 19/18722 0.229991864064252 0.574558429640367 EXOSC8/DCP2 2 GO:0002902 regulation of B cell apoptotic process 2/896 19/18722 0.229991864064252 0.574558429640367 SLC39A10/AURKB 2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/896 19/18722 0.229991864064252 0.574558429640367 GTSE1/SOX4 2 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 2/896 19/18722 0.229991864064252 0.574558429640367 TYMS/DTYMK 2 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 2/896 19/18722 0.229991864064252 0.574558429640367 DUT/UNG 2 GO:0009226 nucleotide-sugar biosynthetic process 2/896 19/18722 0.229991864064252 0.574558429640367 UXS1/GFPT1 2 GO:0030220 platelet formation 2/896 19/18722 0.229991864064252 0.574558429640367 PRKDC/ACTN1 2 GO:0031290 retinal ganglion cell axon guidance 2/896 19/18722 0.229991864064252 0.574558429640367 NRP1/PTPRM 2 GO:0032026 response to magnesium ion 2/896 19/18722 0.229991864064252 0.574558429640367 ANK3/CCND1 2 GO:0035728 response to hepatocyte growth factor 2/896 19/18722 0.229991864064252 0.574558429640367 NRP1/GCLM 2 GO:0036344 platelet morphogenesis 2/896 19/18722 0.229991864064252 0.574558429640367 PRKDC/ACTN1 2 GO:0036498 IRE1-mediated unfolded protein response 2/896 19/18722 0.229991864064252 0.574558429640367 HSPA5/UFL1 2 GO:0044003 modulation by symbiont of host process 2/896 19/18722 0.229991864064252 0.574558429640367 DAG1/ANO6 2 GO:0045019 negative regulation of nitric oxide biosynthetic process 2/896 19/18722 0.229991864064252 0.574558429640367 ROCK2/KHSRP 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/896 19/18722 0.229991864064252 0.574558429640367 TOP2A/TRIM28 2 GO:0046653 tetrahydrofolate metabolic process 2/896 19/18722 0.229991864064252 0.574558429640367 TYMS/DHFR 2 GO:0051444 negative regulation of ubiquitin-protein transferase activity 2/896 19/18722 0.229991864064252 0.574558429640367 MAD2L1/FBXO5 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/896 19/18722 0.229991864064252 0.574558429640367 BRCA1/DNMT1 2 GO:0051957 positive regulation of amino acid transport 2/896 19/18722 0.229991864064252 0.574558429640367 ITGB1/ARL6IP1 2 GO:0060039 pericardium development 2/896 19/18722 0.229991864064252 0.574558429640367 BMP7/SETD2 2 GO:0072074 kidney mesenchyme development 2/896 19/18722 0.229991864064252 0.574558429640367 BMP7/PKD2 2 GO:0097501 stress response to metal ion 2/896 19/18722 0.229991864064252 0.574558429640367 MT2A/HSPA5 2 GO:0097623 potassium ion export across plasma membrane 2/896 19/18722 0.229991864064252 0.574558429640367 DLG1/ANO6 2 GO:1900221 regulation of amyloid-beta clearance 2/896 19/18722 0.229991864064252 0.574558429640367 LRP1/LRPAP1 2 GO:1901659 glycosyl compound biosynthetic process 2/896 19/18722 0.229991864064252 0.574558429640367 DTYMK/MTAP 2 GO:1903204 negative regulation of oxidative stress-induced neuron death 2/896 19/18722 0.229991864064252 0.574558429640367 OXR1/NONO 2 GO:1903975 regulation of glial cell migration 2/896 19/18722 0.229991864064252 0.574558429640367 LRP1/IDH2 2 GO:1904406 negative regulation of nitric oxide metabolic process 2/896 19/18722 0.229991864064252 0.574558429640367 ROCK2/KHSRP 2 GO:0043393 regulation of protein binding 12/896 196/18722 0.23020541848795 0.574791144279012 AURKA/APP/NRP1/AURKB/PLK1/ATP2A2/ID1/TGFBR3/RAN/LRP1/LRPAP1/HSP90AB1 12 GO:0060419 heart growth 7/896 104/18722 0.230332013658598 0.574806603871482 CCNB1/CDK1/GJA1/PARP2/YAP1/TGFBR3/RBPJ 7 GO:0000460 maturation of 5.8S rRNA 3/896 35/18722 0.233925247750916 0.58164538164733 PRKDC/EXOSC8/RPS21 3 GO:0002209 behavioral defense response 3/896 35/18722 0.233925247750916 0.58164538164733 DPP4/GJA1/EIF4G1 3 GO:0021955 central nervous system neuron axonogenesis 3/896 35/18722 0.233925247750916 0.58164538164733 HSP90AA1/NFIB/HSP90AB1 3 GO:0033280 response to vitamin D 3/896 35/18722 0.233925247750916 0.58164538164733 ATP2B1/BMP7/TRIM24 3 GO:0045907 positive regulation of vasoconstriction 3/896 35/18722 0.233925247750916 0.58164538164733 EGFR/GJA5/GJA1 3 GO:0072528 pyrimidine-containing compound biosynthetic process 3/896 35/18722 0.233925247750916 0.58164538164733 TYMS/DUT/DTYMK 3 GO:0098810 neurotransmitter reuptake 3/896 35/18722 0.233925247750916 0.58164538164733 SLC29A1/ITGB1/SLC6A4 3 GO:0010952 positive regulation of peptidase activity 12/896 197/18722 0.235334332793175 0.584844406431347 HMGB1/APP/PERP/ASPH/CASP8AP2/ROCK2/FBLN1/HSPD1/ANP32B/PCOLCE2/CLDN4/PSMD14 12 GO:0007129 homologous chromosome pairing at meiosis 4/896 52/18722 0.237068006845491 0.587623398068729 RAD21/FANCD2/NDC1/CCNE1 4 GO:0010718 positive regulation of epithelial to mesenchymal transition 4/896 52/18722 0.237068006845491 0.587623398068729 EZH2/BMP7/GCNT2/HDAC2 4 GO:0035176 social behavior 4/896 52/18722 0.237068006845491 0.587623398068729 CNTNAP2/SLC6A4/VPS13A/PCM1 4 GO:0043090 amino acid import 4/896 52/18722 0.237068006845491 0.587623398068729 ITGB1/SFXN1/ARL6IP1/SLC1A5 4 GO:0043277 apoptotic cell clearance 4/896 52/18722 0.237068006845491 0.587623398068729 HMGB1/ITGAV/LRP1/TGM2 4 GO:0044070 regulation of anion transport 6/896 87/18722 0.237201583692749 0.587649382744776 TCAF1/ITGB1/GABRE/ARL6IP1/AHCYL1/GOPC 6 GO:0006941 striated muscle contraction 11/896 179/18722 0.239234850772883 0.592379241488456 DSP/DSG2/GJA5/GJA1/ATP1A1/NUP155/DLG1/CALM2/ATP2A2/DSC2/AKAP9 11 GO:0007009 plasma membrane organization 9/896 142/18722 0.24030070339011 0.594709983402998 SPTBN1/ANK3/ATP2A2/DEGS1/EPB41L3/ASAP1/ANO6/SPESP1/MYOF 9 GO:0045861 negative regulation of proteolysis 20/896 351/18722 0.241397472630166 0.597114784630266 PTTG1/BIRC5/APLP2/ITIH5/APP/PBK/DHCR24/CRIM1/ARL6IP1/SMARCC1/BCL2L12/GLG1/SPINT1/SPINT2/LRP1/SERPINH1/USP14/USP47/SERPINF1/HSP90AB1 20 GO:0060415 muscle tissue morphogenesis 5/896 70/18722 0.24332474626634 0.601570346284572 LRP2/DSP/TGFBR3/LY6E/RBPJ 5 GO:1901293 nucleoside phosphate biosynthetic process 15/896 256/18722 0.245931193335331 0.605294610899748 TYMS/RRM1/DUT/PARP1/TK1/DTYMK/RRM2/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/IDH2/TECR 15 GO:0038061 NIK/NF-kappaB signaling 9/896 143/18722 0.246497945322081 0.605294610899748 HMGB1/EGFR/APP/BMP7/RTKN2/NFAT5/DICER1/CALR/TRIM44 9 GO:0051385 response to mineralocorticoid 3/896 36/18722 0.246862305444167 0.605294610899748 ATP2B1/PARP1/CCND1 3 GO:0070897 transcription preinitiation complex assembly 3/896 36/18722 0.246862305444167 0.605294610899748 HMGB1/BDP1/SMARCA4 3 GO:0090313 regulation of protein targeting to membrane 3/896 36/18722 0.246862305444167 0.605294610899748 TCAF1/ANK3/MYO1C 3 GO:0090322 regulation of superoxide metabolic process 3/896 36/18722 0.246862305444167 0.605294610899748 EGFR/BMP7/DHFR 3 GO:1903539 protein localization to postsynaptic membrane 3/896 36/18722 0.246862305444167 0.605294610899748 DAG1/CLSTN1/DLG1 3 GO:0071320 cellular response to cAMP 4/896 53/18722 0.247563509841384 0.605294610899748 APP/PKD2/HSPA5/AKAP9 4 GO:0000272 polysaccharide catabolic process 2/896 20/18722 0.248000892107228 0.605294610899748 HMGB1/AGL 2 GO:0002834 regulation of response to tumor cell 2/896 20/18722 0.248000892107228 0.605294610899748 HMGB1/HSPD1 2 GO:0002837 regulation of immune response to tumor cell 2/896 20/18722 0.248000892107228 0.605294610899748 HMGB1/HSPD1 2 GO:0006883 cellular sodium ion homeostasis 2/896 20/18722 0.248000892107228 0.605294610899748 ATP1A1/ATP1B3 2 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 2/896 20/18722 0.248000892107228 0.605294610899748 TYMS/DUT 2 GO:0010042 response to manganese ion 2/896 20/18722 0.248000892107228 0.605294610899748 APP/HSPA5 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/896 20/18722 0.248000892107228 0.605294610899748 PKD2/CALM2 2 GO:0032211 negative regulation of telomere maintenance via telomerase 2/896 20/18722 0.248000892107228 0.605294610899748 HNRNPU/DCP2 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/896 20/18722 0.248000892107228 0.605294610899748 TOP2A/TRIM28 2 GO:0043011 myeloid dendritic cell differentiation 2/896 20/18722 0.248000892107228 0.605294610899748 ITGB8/RBPJ 2 GO:0043586 tongue development 2/896 20/18722 0.248000892107228 0.605294610899748 EGFR/HDAC2 2 GO:0051900 regulation of mitochondrial depolarization 2/896 20/18722 0.248000892107228 0.605294610899748 PARP1/GCLM 2 GO:0070932 histone H3 deacetylation 2/896 20/18722 0.248000892107228 0.605294610899748 SFPQ/HDAC2 2 GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/896 20/18722 0.248000892107228 0.605294610899748 HMGB1/LRP1 2 GO:0097150 neuronal stem cell population maintenance 2/896 20/18722 0.248000892107228 0.605294610899748 ASPM/PCM1 2 GO:1901679 nucleotide transmembrane transport 2/896 20/18722 0.248000892107228 0.605294610899748 SLC25A36/SLC25A5 2 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/896 20/18722 0.248000892107228 0.605294610899748 HMGB1/LRP1 2 GO:0034250 positive regulation of cellular amide metabolic process 10/896 162/18722 0.248827409289057 0.607001559502279 PRKDC/SOX4/ROCK2/AGO2/HNRNPD/DHX9/KHDRBS1/LARP1/EIF4G1/FMR1 10 GO:0055007 cardiac muscle cell differentiation 8/896 125/18722 0.249588353001718 0.60823624156723 CCNB1/CDK1/ITGB1/PARP2/HNRNPU/CALR/RBPJ/CACYBP 8 GO:2000027 regulation of animal organ morphogenesis 8/896 125/18722 0.249588353001718 0.60823624156723 BMP7/ZNRF3/FZD6/LGR4/AHI1/RYK/TACSTD2/MAGED1 8 GO:0030323 respiratory tube development 11/896 181/18722 0.250242926454413 0.609520270863963 HMGB1/EGFR/MME/DAG1/LAMA5/NFIB/YAP1/DLG5/ASXL1/HSPB11/RBPJ 11 GO:0097191 extrinsic apoptotic signaling pathway 13/896 219/18722 0.251205293854539 0.611552306405696 HMGB2/ITGA6/ITGAV/BRCA1/NRP1/PHIP/CASP8AP2/PARP2/GCLM/YAP1/BCL2L12/PDIA3/SIVA1 13 GO:0021761 limbic system development 7/896 107/18722 0.251988263395003 0.613145754050837 NRP2/EZH2/NRP1/KIF14/CNTNAP2/CDK6/KIF5B 7 GO:0033555 multicellular organismal response to stress 5/896 71/18722 0.252380972755872 0.613475949051187 DPP4/GJA1/ADRB1/VWA1/EIF4G1 5 GO:0050795 regulation of behavior 5/896 71/18722 0.252380972755872 0.613475949051187 GJA1/ADRB1/ZFHX3/AHI1/HDAC2 5 GO:0106106 cold-induced thermogenesis 9/896 144/18722 0.252749029046334 0.613745607663885 GJA1/IGF1R/ADRB1/LGR4/PRLR/DYNC1H1/ID1/RBPJ/RHEB 9 GO:0120161 regulation of cold-induced thermogenesis 9/896 144/18722 0.252749029046334 0.613745607663885 GJA1/IGF1R/ADRB1/LGR4/PRLR/DYNC1H1/ID1/RBPJ/RHEB 9 GO:0009952 anterior/posterior pattern specification 12/896 201/18722 0.256278967975511 0.622000911598926 PRKDC/AURKA/WLS/NR2F2/PGAP1/LRP5/XRCC2/FZD5/PBX1/COBL/BPTF/RBPJ 12 GO:0051703 biological process involved in intraspecies interaction between organisms 4/896 54/18722 0.258157182248233 0.625287868114188 CNTNAP2/SLC6A4/VPS13A/PCM1 4 GO:0072348 sulfur compound transport 4/896 54/18722 0.258157182248233 0.625287868114188 RACGAP1/GJA1/SLC26A2/SLC13A3 4 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 4/896 54/18722 0.258157182248233 0.625287868114188 TEAD1/NFIB/KLF5/SMARCA4 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/896 54/18722 0.258157182248233 0.625287868114188 ASPM/LRP2/ADGRG1/NAP1L1 4 GO:0031349 positive regulation of defense response 16/896 278/18722 0.25881497559797 0.625398184661418 HMGB2/HMGB1/PRKDC/EGFR/APP/CADM1/HSP90AA1/GJA1/SFPQ/DHX9/PSPC1/HSPD1/NONO/XRCC5/XRCC6/TGM2 16 GO:0045927 positive regulation of growth 15/896 259/18722 0.259890478625893 0.625398184661418 CCNB1/CDK1/PRKDC/EGFR/NRP1/PARP2/YAP1/TFCP2L1/GOLGA4/MACF1/TGFBR3/EIF4G1/LRP1/USP47/RBPJ 15 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3/896 37/18722 0.25990573908007 0.625398184661418 DCP2/RNPS1/PNRC2 3 GO:0003161 cardiac conduction system development 3/896 37/18722 0.25990573908007 0.625398184661418 DSG2/GJA5/GJA1 3 GO:0006623 protein targeting to vacuole 3/896 37/18722 0.25990573908007 0.625398184661418 VPS13A/NEDD4/HSPA8 3 GO:0031646 positive regulation of nervous system process 3/896 37/18722 0.25990573908007 0.625398184661418 DAG1/PARD3/DICER1 3 GO:0032570 response to progesterone 3/896 37/18722 0.25990573908007 0.625398184661418 TYMS/YAP1/CLDN4 3 GO:0043403 skeletal muscle tissue regeneration 3/896 37/18722 0.25990573908007 0.625398184661418 DAG1/EZH2/KLF5 3 GO:0043687 post-translational protein modification 3/896 37/18722 0.25990573908007 0.625398184661418 ICMT/ESCO2/STT3B 3 GO:0048009 insulin-like growth factor receptor signaling pathway 3/896 37/18722 0.25990573908007 0.625398184661418 IGF1R/PHIP/CRIM1 3 GO:0060428 lung epithelium development 3/896 37/18722 0.25990573908007 0.625398184661418 NFIB/YAP1/RBPJ 3 GO:0062237 protein localization to postsynapse 3/896 37/18722 0.25990573908007 0.625398184661418 DAG1/CLSTN1/DLG1 3 GO:1905332 positive regulation of morphogenesis of an epithelium 3/896 37/18722 0.25990573908007 0.625398184661418 GJA1/LGR4/MAGED1 3 GO:2001242 regulation of intrinsic apoptotic signaling pathway 10/896 164/18722 0.260642910953103 0.626856048811142 HELLS/PARP1/RTKN2/FIGNL1/SFPQ/P4HB/USP47/NONO/BCLAF1/ERP29 10 GO:0034109 homotypic cell-cell adhesion 6/896 90/18722 0.261338797378298 0.627383736639103 DSP/DSG2/ANK3/DSC2/RDX/VCL 6 GO:0042475 odontogenesis of dentin-containing tooth 6/896 90/18722 0.261338797378298 0.627383736639103 PERP/BMP7/LAMA5/ANKRD11/HDAC2/BSG 6 GO:0046849 bone remodeling 6/896 90/18722 0.261338797378298 0.627383736639103 EGFR/GJA1/LRP5/NF1/LGR4/SUCO 6 GO:0001707 mesoderm formation 5/896 72/18722 0.261519404254674 0.627383736639103 WLS/BMP7/ITGB1/ITGB4/GJA1 5 GO:0042246 tissue regeneration 5/896 72/18722 0.261519404254674 0.627383736639103 CCNB1/DAG1/EZH2/KLF5/YAP1 5 GO:0035270 endocrine system development 8/896 127/18722 0.263136198375838 0.630312198216883 CDH1/SOX4/PBX1/NF1/CDK6/LY6E/RBPJ/RHEB 8 GO:0048565 digestive tract development 8/896 127/18722 0.263136198375838 0.630312198216883 TYMS/CCNB1/EGFR/KLF5/YAP1/COBL/LGR4/AHI1 8 GO:0051224 negative regulation of protein transport 8/896 127/18722 0.263136198375838 0.630312198216883 LMAN1/BARD1/FRMD4A/FERMT1/GOPC/UBE2G2/IDH2/ERP29 8 GO:0043542 endothelial cell migration 16/896 279/18722 0.263355512124898 0.630521170954998 HMGB1/MET/NRP2/DPP4/ITGB1/NRP1/NR2F2/AMOT/FSTL1/EMP2/NF1/ROCK2/PTPRM/ID1/CALR/SERPINF1 16 GO:0048813 dendrite morphogenesis 9/896 146/18722 0.265404126360001 0.632220131495319 ITGB1/NRP1/TPBG/YWHAH/VLDLR/PPP1R9A/RERE/NEDD4/ID1 9 GO:0000002 mitochondrial genome maintenance 2/896 21/18722 0.266051580262693 0.632220131495319 PARP1/SLC25A36 2 GO:0003177 pulmonary valve development 2/896 21/18722 0.266051580262693 0.632220131495319 GJA5/RBPJ 2 GO:0006067 ethanol metabolic process 2/896 21/18722 0.266051580262693 0.632220131495319 ACSS1/ADH5 2 GO:0006244 pyrimidine nucleotide catabolic process 2/896 21/18722 0.266051580262693 0.632220131495319 DUT/UNG 2 GO:0006353 DNA-templated transcription, termination 2/896 21/18722 0.266051580262693 0.632220131495319 TTF2/DHX9 2 GO:0006925 inflammatory cell apoptotic process 2/896 21/18722 0.266051580262693 0.632220131495319 CDKN2A/CTSL 2 GO:0007289 spermatid nucleus differentiation 2/896 21/18722 0.266051580262693 0.632220131495319 HMGB2/SRPK1 2 GO:0035330 regulation of hippo signaling 2/896 21/18722 0.266051580262693 0.632220131495319 CIT/DLG5 2 GO:0060972 left/right pattern formation 2/896 21/18722 0.266051580262693 0.632220131495319 AHI1/HSPB11 2 GO:0090026 positive regulation of monocyte chemotaxis 2/896 21/18722 0.266051580262693 0.632220131495319 HMGB1/ANO6 2 GO:0099515 actin filament-based transport 2/896 21/18722 0.266051580262693 0.632220131495319 SYNE2/MYO1C 2 GO:1902473 regulation of protein localization to synapse 2/896 21/18722 0.266051580262693 0.632220131495319 DAG1/DLG1 2 GO:1903429 regulation of cell maturation 2/896 21/18722 0.266051580262693 0.632220131495319 AURKA/KIF14 2 GO:2000291 regulation of myoblast proliferation 2/896 21/18722 0.266051580262693 0.632220131495319 MEIS2/PAXBP1 2 GO:0055001 muscle cell development 11/896 184/18722 0.267081105902644 0.634350845561801 CCNB1/CDK1/ITGB1/PARP2/ATP2A2/ACTN1/HNRNPU/FBXO22/AFG3L2/CSRP2/MYOF 11 GO:0006360 transcription by RNA polymerase I 4/896 55/18722 0.268838045923962 0.637572196344259 TCOF1/SMARCA4/NCL/POLR2L 4 GO:0044091 membrane biogenesis 4/896 55/18722 0.268838045923962 0.637572196344259 SPTBN1/ANK3/EMP2/ANKLE2 4 GO:0061614 pri-miRNA transcription by RNA polymerase II 4/896 55/18722 0.268838045923962 0.637572196344259 TEAD1/NFIB/KLF5/SMARCA4 4 GO:0002065 columnar/cuboidal epithelial cell differentiation 6/896 91/18722 0.269524832349197 0.638883589689706 TYMS/SOX4/KLF5/YAP1/CDK6/RHEB 6 GO:0035303 regulation of dephosphorylation 8/896 128/18722 0.269990995711743 0.639670974455514 HSP90B1/SLC39A10/CDCA2/MASTL/CALM2/ROCK2/ANKLE2/HSP90AB1 8 GO:0009166 nucleotide catabolic process 5/896 73/18722 0.270733122247957 0.641111074212175 DUT/NUDT15/UNG/HINT1/NUDT4 5 GO:1902652 secondary alcohol metabolic process 9/896 147/18722 0.271803785736777 0.643327354044311 APP/LBR/DHCR24/LRP5/VLDLR/FDPS/SQLE/LIMA1/IDH2 9 GO:0043112 receptor metabolic process 10/896 166/18722 0.272637514895128 0.644292681375594 ITGB1/RNF43/FUT8/ZNRF3/AHI1/NEDD4/FMR1/LRP1/LRPAP1/CLTC 10 GO:0001825 blastocyst formation 3/896 38/18722 0.273035513973987 0.644292681375594 YAP1/CNOT1/RTN4 3 GO:0010613 positive regulation of cardiac muscle hypertrophy 3/896 38/18722 0.273035513973987 0.644292681375594 PARP1/PARP2/ROCK2 3 GO:0099622 cardiac muscle cell membrane repolarization 3/896 38/18722 0.273035513973987 0.644292681375594 GJA5/ATP1A1/AKAP9 3 GO:1901186 positive regulation of ERBB signaling pathway 3/896 38/18722 0.273035513973987 0.644292681375594 DGKD/RBPJ/RTN4 3 GO:2000279 negative regulation of DNA biosynthetic process 3/896 38/18722 0.273035513973987 0.644292681375594 GJA1/HNRNPU/DCP2 3 GO:0009306 protein secretion 20/896 359/18722 0.273268760639268 0.644292681375594 MYH10/EGFR/WLS/DPP4/PDIA4/GJA1/LRP5/EXPH5/SOX4/SLC16A1/FRMD4A/TM7SF3/CANX/CAMK2G/KIF5B/CD2AP/LRP1/FAM3B/IDH2/ERP29 20 GO:0009895 negative regulation of catabolic process 18/896 320/18722 0.273291302845743 0.644292681375594 FUS/MET/EGFR/MAD2L1/PBK/SMARCC1/HNRNPD/LRPPRC/DHX9/HNRNPU/TAF15/LARP1/SYNCRIP/EIF4G1/FMR1/USP14/THRAP3/HSP90AB1 18 GO:0050878 regulation of body fluid levels 21/896 379/18722 0.27502229305119 0.648053517782024 STMN1/F5/MET/EGFR/LMAN1/SLC29A1/GJA5/GJA1/EMP2/CCND1/DGKD/PPAT/FZD6/FBLN1/PRLR/VCL/VKORC1/HPS5/ANO6/LSR/CLDN4 21 GO:0007498 mesoderm development 8/896 129/18722 0.276896046096156 0.652146879162827 WLS/BMP7/ITGB1/ITGB4/GJA1/YAP1/MEST/SETD2 8 GO:0035592 establishment of protein localization to extracellular region 20/896 360/18722 0.27735891399279 0.65291491883707 MYH10/EGFR/WLS/DPP4/PDIA4/GJA1/LRP5/EXPH5/SOX4/SLC16A1/FRMD4A/TM7SF3/CANX/CAMK2G/KIF5B/CD2AP/LRP1/FAM3B/IDH2/ERP29 20 GO:0014074 response to purine-containing compound 9/896 148/18722 0.278248583603985 0.654363910406614 HSP90B1/APP/PKD2/SLC6A4/HSPA5/AKAP9/HSPD1/HDAC2/BSG 9 GO:0044272 sulfur compound biosynthetic process 9/896 148/18722 0.278248583603985 0.654363910406614 MTR/GCLM/SLC26A2/CHST14/CHPF/MTAP/SLC25A1/ACSS1/TECR 9 GO:0030166 proteoglycan biosynthetic process 4/896 56/18722 0.279595284480469 0.655593265279843 HS6ST2/EXTL2/CHST14/CHPF 4 GO:0032608 interferon-beta production 4/896 56/18722 0.279595284480469 0.655593265279843 HMGB2/HMGB1/HSP90AA1/DHX9 4 GO:0032648 regulation of interferon-beta production 4/896 56/18722 0.279595284480469 0.655593265279843 HMGB2/HMGB1/HSP90AA1/DHX9 4 GO:0042733 embryonic digit morphogenesis 4/896 56/18722 0.279595284480469 0.655593265279843 LRP5/FREM2/FZD6/HDAC2 4 GO:0070534 protein K63-linked ubiquitination 4/896 56/18722 0.279595284480469 0.655593265279843 UBE2S/UBE2T/RNF168/NEDD4 4 GO:0071385 cellular response to glucocorticoid stimulus 4/896 56/18722 0.279595284480469 0.655593265279843 EGFR/ATP2B1/HNRNPU/SERPINF1 4 GO:0046470 phosphatidylcholine metabolic process 5/896 74/18722 0.280015242438653 0.65625565410021 CHPT1/SLC44A2/CDS1/SLC44A1/DBI 5 GO:0006898 receptor-mediated endocytosis 14/896 244/18722 0.280596096491284 0.657294290799505 LRP2/ITGAV/ITGB1/DGKD/VLDLR/AHI1/NEDD4/CANX/FMR1/CD2AP/LRP1/LRPAP1/CLTC/CTSL 14 GO:0090288 negative regulation of cellular response to growth factor stimulus 7/896 111/18722 0.281745553693797 0.659663204185477 LRP2/FBN1/CRIM1/SEMA6A/CTDSPL2/NEDD4/TRIM33 7 GO:0001933 negative regulation of protein phosphorylation 19/896 342/18722 0.283925214850904 0.660958776935553 CCNB1/PRKDC/PBK/BMP7/SUZ12/IPO7/NR2F2/PLK1/PARD3/LRP5/IPO5/NCAPG2/CALM2/NF1/CDKN2A/CTDSPL/FBLN1/EIF4G1/LRP1 19 GO:0002320 lymphoid progenitor cell differentiation 2/896 22/18722 0.284098745343895 0.660958776935553 PRKDC/SOX4 2 GO:0008211 glucocorticoid metabolic process 2/896 22/18722 0.284098745343895 0.660958776935553 ATP1A1/YWHAH 2 GO:0021854 hypothalamus development 2/896 22/18722 0.284098745343895 0.660958776935553 NRP2/NRP1 2 GO:0035268 protein mannosylation 2/896 22/18722 0.284098745343895 0.660958776935553 TMTC3/DPY19L1 2 GO:0035561 regulation of chromatin binding 2/896 22/18722 0.284098745343895 0.660958776935553 GMNN/CDT1 2 GO:0046628 positive regulation of insulin receptor signaling pathway 2/896 22/18722 0.284098745343895 0.660958776935553 NUCKS1/SNX5 2 GO:0051220 cytoplasmic sequestering of protein 2/896 22/18722 0.284098745343895 0.660958776935553 PKD2/GOPC 2 GO:0051412 response to corticosterone 2/896 22/18722 0.284098745343895 0.660958776935553 ATP2B1/CCND1 2 GO:0060965 negative regulation of gene silencing by miRNA 2/896 22/18722 0.284098745343895 0.660958776935553 LIN28B/KCNQ1OT1 2 GO:0071359 cellular response to dsRNA 2/896 22/18722 0.284098745343895 0.660958776935553 COLEC12/DHX9 2 GO:0097164 ammonium ion metabolic process 2/896 22/18722 0.284098745343895 0.660958776935553 SLC44A1/ALDH7A1 2 GO:1900120 regulation of receptor binding 2/896 22/18722 0.284098745343895 0.660958776935553 NRP1/ATP2A2 2 GO:0010463 mesenchymal cell proliferation 3/896 39/18722 0.286232321336246 0.664303890160057 BMP7/LRP5/NFIB 3 GO:0014742 positive regulation of muscle hypertrophy 3/896 39/18722 0.286232321336246 0.664303890160057 PARP1/PARP2/ROCK2 3 GO:0045823 positive regulation of heart contraction 3/896 39/18722 0.286232321336246 0.664303890160057 ATP1A1/ADRB1/ATP2A2 3 GO:0071548 response to dexamethasone 3/896 39/18722 0.286232321336246 0.664303890160057 PCNA/EGFR/SERPINF1 3 GO:2000249 regulation of actin cytoskeleton reorganization 3/896 39/18722 0.286232321336246 0.664303890160057 IQGAP2/NRP1/CD2AP 3 GO:0045936 negative regulation of phosphate metabolic process 24/896 441/18722 0.286567948390558 0.664759662593064 CCNB1/PRKDC/PBK/BMP7/PARP1/SUZ12/IPO7/NR2F2/PLK1/PARD3/LRP5/IPO5/NCAPG2/MASTL/CALM2/NF1/ROCK2/CDKN2A/CTDSPL/ANKLE2/FBLN1/HNRNPU/EIF4G1/LRP1 24 GO:0043406 positive regulation of MAP kinase activity 7/896 112/18722 0.289318791052676 0.670256924259226 EGFR/EZH2/FZD5/IQGAP1/MAGED1/CD24/ERP29 7 GO:0006024 glycosaminoglycan biosynthetic process 5/896 75/18722 0.289358927712247 0.670256924259226 HS6ST2/GCNT2/CHST14/CHPF/CLTC 5 GO:2001259 positive regulation of cation channel activity 5/896 75/18722 0.289358927712247 0.670256924259226 ANK3/PKD2/ALG10B/CALM2/KIF5B 5 GO:0030308 negative regulation of cell growth 11/896 188/18722 0.29007789404329 0.670433654009307 SMARCA2/NRP1/SEMA6D/GJA1/DCBLD2/SEMA6A/CDKN2A/RYK/SMARCA4/RBBP7/RTN4 11 GO:0010563 negative regulation of phosphorus metabolic process 24/896 442/18722 0.290335581272491 0.670433654009307 CCNB1/PRKDC/PBK/BMP7/PARP1/SUZ12/IPO7/NR2F2/PLK1/PARD3/LRP5/IPO5/NCAPG2/MASTL/CALM2/NF1/ROCK2/CDKN2A/CTDSPL/ANKLE2/FBLN1/HNRNPU/EIF4G1/LRP1 24 GO:0010883 regulation of lipid storage 4/896 57/18722 0.290418264870391 0.670433654009307 ITGAV/ASXL1/MEST/HILPDA 4 GO:0033619 membrane protein proteolysis 4/896 57/18722 0.290418264870391 0.670433654009307 DAG1/RBMX/SPPL2A/AFG3L2 4 GO:0050891 multicellular organismal water homeostasis 4/896 57/18722 0.290418264870391 0.670433654009307 STMN1/MET/LSR/CLDN4 4 GO:0097120 receptor localization to synapse 4/896 57/18722 0.290418264870391 0.670433654009307 DAG1/CLSTN1/DLG1/KIF5B 4 GO:1902017 regulation of cilium assembly 4/896 57/18722 0.290418264870391 0.670433654009307 CCP110/CEP135/YAP1/ATMIN 4 GO:1904950 negative regulation of establishment of protein localization 8/896 131/18722 0.290845820509931 0.670974385767216 LMAN1/BARD1/FRMD4A/FERMT1/GOPC/UBE2G2/IDH2/ERP29 8 GO:0006937 regulation of muscle contraction 10/896 169/18722 0.290933594163833 0.670974385767216 DSP/ATP2B1/DSG2/GJA5/ATP1A1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 10 GO:0019080 viral gene expression 6/896 94/18722 0.294436659417984 0.678397978794138 NUCKS1/FUT8/EIF3A/DHX9/SMARCA4/CANX 6 GO:0051702 biological process involved in interaction with symbiont 6/896 94/18722 0.294436659417984 0.678397978794138 NUCKS1/SMARCA4/HSPD1/FMR1/HSPA8/DDB1 6 GO:0031623 receptor internalization 7/896 113/18722 0.296938450798659 0.682875094773518 ITGB1/AHI1/NEDD4/FMR1/LRP1/LRPAP1/CLTC 7 GO:0030178 negative regulation of Wnt signaling pathway 10/896 170/18722 0.297106048420458 0.682875094773518 RNF43/TPBG/ZNRF3/FZD6/FERMT1/HMGXB4/G3BP1/CTNND1/LRP1/TLE4 10 GO:0045667 regulation of osteoblast differentiation 8/896 132/18722 0.297884974294459 0.682875094773518 FBN2/BMP7/FBXO5/LRP5/CRIM1/YAP1/SUCO/CDK6 8 GO:0008652 cellular amino acid biosynthetic process 5/896 76/18722 0.298757400357731 0.682875094773518 DHFR/PLOD2/MTR/BCAT1/MTAP 5 GO:0014823 response to activity 5/896 76/18722 0.298757400357731 0.682875094773518 CDK1/PRKDC/COL4A2/GCLM/HSPD1 5 GO:0021536 diencephalon development 5/896 76/18722 0.298757400357731 0.682875094773518 CDH1/NRP2/NRP1/CNTNAP2/RBPJ 5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 5/896 76/18722 0.298757400357731 0.682875094773518 BRCA2/PERP/MSH2/HINT1/TMEM109 5 GO:0042326 negative regulation of phosphorylation 21/896 385/18722 0.299272346276348 0.682875094773518 CCNB1/PRKDC/PBK/BMP7/SUZ12/IPO7/NR2F2/PLK1/PARD3/LRP5/IPO5/NCAPG2/CALM2/NF1/CDKN2A/CTDSPL/ANKLE2/FBLN1/HNRNPU/EIF4G1/LRP1 21 GO:0007339 binding of sperm to zona pellucida 3/896 40/18722 0.29947759983919 0.682875094773518 CCT5/CCT2/CCT4 3 GO:0009069 serine family amino acid metabolic process 3/896 40/18722 0.29947759983919 0.682875094773518 DHFR/GLDC/GCLM 3 GO:0045022 early endosome to late endosome transport 3/896 40/18722 0.29947759983919 0.682875094773518 EMP2/RDX/EEA1 3 GO:0045429 positive regulation of nitric oxide biosynthetic process 3/896 40/18722 0.29947759983919 0.682875094773518 HSP90AA1/PKD2/HSP90AB1 3 GO:0045777 positive regulation of blood pressure 3/896 40/18722 0.29947759983919 0.682875094773518 NR2F2/ADRB1/ADH5 3 GO:0046365 monosaccharide catabolic process 3/896 40/18722 0.29947759983919 0.682875094773518 LRP5/FUT8/GLB1 3 GO:0060412 ventricular septum morphogenesis 3/896 40/18722 0.29947759983919 0.682875094773518 SOX4/TGFBR3/RBPJ 3 GO:0072210 metanephric nephron development 3/896 40/18722 0.29947759983919 0.682875094773518 PKD2/LGR4/IRX2 3 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 3/896 40/18722 0.29947759983919 0.682875094773518 PKD2/CALM2/FMR1 3 GO:2000142 regulation of DNA-templated transcription, initiation 3/896 40/18722 0.29947759983919 0.682875094773518 HMGB1/ZNF451/BCLAF1 3 GO:1902905 positive regulation of supramolecular fiber organization 12/896 209/18722 0.299967335698062 0.682875094773518 MET/APP/IQGAP2/NRP1/CKAP5/CDK5RAP2/DLG1/ROCK2/MYO1C/ID1/CLIP1/AKAP9 12 GO:0009161 ribonucleoside monophosphate metabolic process 4/896 58/18722 0.301296556917095 0.682875094773518 GMPS/DLG1/PPAT/PAICS 4 GO:0045604 regulation of epidermal cell differentiation 4/896 58/18722 0.301296556917095 0.682875094773518 EZH2/ESRP1/ROCK2/NCOA3 4 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 2/896 23/18722 0.302101424415934 0.682875094773518 MME/ENPEP 2 GO:0003283 atrial septum development 2/896 23/18722 0.302101424415934 0.682875094773518 GJA5/SOX4 2 GO:0003323 type B pancreatic cell development 2/896 23/18722 0.302101424415934 0.682875094773518 CDK6/RHEB 2 GO:0006622 protein targeting to lysosome 2/896 23/18722 0.302101424415934 0.682875094773518 NEDD4/HSPA8 2 GO:0006929 substrate-dependent cell migration 2/896 23/18722 0.302101424415934 0.682875094773518 NRP1/CD2AP 2 GO:0010888 negative regulation of lipid storage 2/896 23/18722 0.302101424415934 0.682875094773518 ITGAV/ASXL1 2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 2/896 23/18722 0.302101424415934 0.682875094773518 CLDN4/CLDN7 2 GO:0016578 histone deubiquitination 2/896 23/18722 0.302101424415934 0.682875094773518 USP22/ASXL1 2 GO:0019430 removal of superoxide radicals 2/896 23/18722 0.302101424415934 0.682875094773518 BMP7/DHFR 2 GO:0021884 forebrain neuron development 2/896 23/18722 0.302101424415934 0.682875094773518 NRP2/NRP1 2 GO:0030539 male genitalia development 2/896 23/18722 0.302101424415934 0.682875094773518 DHCR24/LGR4 2 GO:0036303 lymph vessel morphogenesis 2/896 23/18722 0.302101424415934 0.682875094773518 SVEP1/PTPN14 2 GO:0045943 positive regulation of transcription by RNA polymerase I 2/896 23/18722 0.302101424415934 0.682875094773518 SMARCA4/NCL 2 GO:0051882 mitochondrial depolarization 2/896 23/18722 0.302101424415934 0.682875094773518 PARP1/GCLM 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/896 23/18722 0.302101424415934 0.682875094773518 GJA5/AKAP9 2 GO:0071305 cellular response to vitamin D 2/896 23/18722 0.302101424415934 0.682875094773518 ATP2B1/TRIM24 2 GO:0071636 positive regulation of transforming growth factor beta production 2/896 23/18722 0.302101424415934 0.682875094773518 CD46/FERMT1 2 GO:0090335 regulation of brown fat cell differentiation 2/896 23/18722 0.302101424415934 0.682875094773518 BMP7/HNRNPU 2 GO:1900273 positive regulation of long-term synaptic potentiation 2/896 23/18722 0.302101424415934 0.682875094773518 APP/MME 2 GO:0042982 amyloid precursor protein metabolic process 6/896 95/18722 0.302842553971495 0.683902721220396 DHCR24/PAWR/DLG1/ROCK2/AGO2/RTN4 6 GO:0050764 regulation of phagocytosis 6/896 95/18722 0.302842553971495 0.683902721220396 HMGB1/ITGAV/CALR/ANO6/LRP1/TGM2 6 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7/896 114/18722 0.304600958533568 0.686898902238666 BMP7/PARP1/TTK/FERMT1/TGFBR3/RBPJ/HSP90AB1 7 GO:1901800 positive regulation of proteasomal protein catabolic process 7/896 114/18722 0.304600958533568 0.686898902238666 AURKA/CDC20/PLK1/TMTC3/FBXO22/RNF217/FMR1 7 GO:1903008 organelle disassembly 7/896 114/18722 0.304600958533568 0.686898902238666 CDK1/VRK1/FZD5/HUWE1/KIF5B/UFL1/SLC25A5 7 GO:0045926 negative regulation of growth 14/896 249/18722 0.3060466158403 0.689833118046078 SMARCA2/NRP1/SEMA6D/GJA1/DCBLD2/ADRB1/SEMA6A/MT2A/SLC6A4/CDKN2A/RYK/SMARCA4/RBBP7/RTN4 14 GO:0048644 muscle organ morphogenesis 5/896 77/18722 0.308203953549332 0.694367944428745 LRP2/DSP/TGFBR3/LY6E/RBPJ 5 GO:0050807 regulation of synapse organization 12/896 211/18722 0.311203379515865 0.700794780098462 TUBB/NRP2/APP/DAG1/CDC20/TPBG/CLSTN1/PPP1R9A/DLG5/NEDD4/EIF4G1/HSPA8 12 GO:0032147 activation of protein kinase activity 8/896 134/18722 0.31207784254371 0.700979086386093 TPX2/HMGB1/ECT2/CLSPN/KIF14/EMP2/DLG1/PRLR 8 GO:0071806 protein transmembrane transport 4/896 59/18722 0.312219950872141 0.700979086386093 TRAM2/SEC63/HSPA5/HSPD1 4 GO:2001258 negative regulation of cation channel activity 4/896 59/18722 0.312219950872141 0.700979086386093 ANK3/PKD2/CALM2/FMR1 4 GO:0030278 regulation of ossification 7/896 115/18722 0.312302746045936 0.700979086386093 FBN2/ATP2B1/BMP7/PBX1/ANKH/ANO6/RBPJ 7 GO:0001953 negative regulation of cell-matrix adhesion 3/896 41/18722 0.312753551320146 0.700979086386093 CDKN2A/LRP1/RASA1 3 GO:0032733 positive regulation of interleukin-10 production 3/896 41/18722 0.312753551320146 0.700979086386093 HMGB1/CD46/HSPD1 3 GO:0050691 regulation of defense response to virus by host 3/896 41/18722 0.312753551320146 0.700979086386093 HSP90AA1/DHX9/TRIM44 3 GO:1903524 positive regulation of blood circulation 3/896 41/18722 0.312753551320146 0.700979086386093 ATP1A1/ADRB1/ATP2A2 3 GO:1904407 positive regulation of nitric oxide metabolic process 3/896 41/18722 0.312753551320146 0.700979086386093 HSP90AA1/PKD2/HSP90AB1 3 GO:1905314 semi-lunar valve development 3/896 41/18722 0.312753551320146 0.700979086386093 GJA5/ROCK2/RBPJ 3 GO:0003015 heart process 14/896 251/18722 0.316403564773395 0.708827131970056 DSP/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/NUP155/ADRB1/DLG1/CALM2/ATP2A2/DSC2/YAP1/AKAP9 14 GO:0009749 response to glucose 12/896 212/18722 0.316861094722325 0.709318561572696 SLC29A1/GJA1/CTSV/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 12 GO:0008306 associative learning 5/896 78/18722 0.317691962096194 0.709318561572696 APP/ITGB1/TPBG/MEIS2/NF1 5 GO:0030500 regulation of bone mineralization 5/896 78/18722 0.317691962096194 0.709318561572696 FBN2/ATP2B1/BMP7/ANKH/ANO6 5 GO:0032024 positive regulation of insulin secretion 5/896 78/18722 0.317691962096194 0.709318561572696 GJA1/SOX4/TM7SF3/KIF5B/LRP1 5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 5/896 78/18722 0.317691962096194 0.709318561572696 BIRC5/DHCR24/ARL6IP1/BCL2L12/USP47 5 GO:0007605 sensory perception of sound 9/896 154/18722 0.317740036464652 0.709318561572696 LRP2/BIRC5/PGAP1/MARVELD2/TBL1X/USP53/HEXB/ALDH7A1/TRIOBP 9 GO:0050770 regulation of axonogenesis 9/896 154/18722 0.317740036464652 0.709318561572696 NRP1/SEMA6D/SEMA6A/PLXNB1/RYK/GOLGA4/MACF1/LRP1/RTN4 9 GO:0043255 regulation of carbohydrate biosynthetic process 6/896 97/18722 0.319778768813504 0.709318561572696 SLC35B4/SOGA1/PGP/RANBP2/CLTC/DDB1 6 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/896 24/18722 0.3200225750856 0.709318561572696 EXOSC8/RPS21 2 GO:0001702 gastrulation with mouth forming second 2/896 24/18722 0.3200225750856 0.709318561572696 AMOT/LRP5 2 GO:0001783 B cell apoptotic process 2/896 24/18722 0.3200225750856 0.709318561572696 SLC39A10/AURKB 2 GO:0006213 pyrimidine nucleoside metabolic process 2/896 24/18722 0.3200225750856 0.709318561572696 TK1/DTYMK 2 GO:0006817 phosphate ion transport 2/896 24/18722 0.3200225750856 0.709318561572696 SLC20A1/ANKH 2 GO:0010226 response to lithium ion 2/896 24/18722 0.3200225750856 0.709318561572696 CDH1/CALR 2 GO:0010288 response to lead ion 2/896 24/18722 0.3200225750856 0.709318561572696 APP/DNMT3A 2 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 2/896 24/18722 0.3200225750856 0.709318561572696 HSPA5/RBPJ 2 GO:0060149 negative regulation of posttranscriptional gene silencing 2/896 24/18722 0.3200225750856 0.709318561572696 LIN28B/KCNQ1OT1 2 GO:0060967 negative regulation of gene silencing by RNA 2/896 24/18722 0.3200225750856 0.709318561572696 LIN28B/KCNQ1OT1 2 GO:0071294 cellular response to zinc ion 2/896 24/18722 0.3200225750856 0.709318561572696 PARP1/MT2A 2 GO:0071577 zinc ion transmembrane transport 2/896 24/18722 0.3200225750856 0.709318561572696 SLC39A10/SLC39A1 2 GO:0072530 purine-containing compound transmembrane transport 2/896 24/18722 0.3200225750856 0.709318561572696 SLC29A1/SLC25A5 2 GO:0008286 insulin receptor signaling pathway 7/896 116/18722 0.320040255891828 0.709318561572696 NUCKS1/KANK1/IGF1R/PHIP/SOGA1/SMARCC1/SNX5 7 GO:0035967 cellular response to topologically incorrect protein 7/896 116/18722 0.320040255891828 0.709318561572696 CCND1/TM7SF3/HSPA5/HSPD1/HSPA9/UFL1/HSPA8 7 GO:0043583 ear development 12/896 213/18722 0.322543448029953 0.714284273385884 CCNA2/LGR5/MCOLN3/ESRP1/MCM2/FREM2/FZD6/AHI1/TRIP11/ANP32B/RBPJ/TRIOBP 12 GO:0006081 cellular aldehyde metabolic process 4/896 60/18722 0.323178473086198 0.714284273385884 ALDH7A1/AKR7A2/IDH2/ADH5 4 GO:0033866 nucleoside bisphosphate biosynthetic process 4/896 60/18722 0.323178473086198 0.714284273385884 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0034030 ribonucleoside bisphosphate biosynthetic process 4/896 60/18722 0.323178473086198 0.714284273385884 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0034033 purine nucleoside bisphosphate biosynthetic process 4/896 60/18722 0.323178473086198 0.714284273385884 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0051851 modulation by host of symbiont process 4/896 60/18722 0.323178473086198 0.714284273385884 NUCKS1/SMARCA4/FMR1/HSPA8 4 GO:0021795 cerebral cortex cell migration 3/896 42/18722 0.326043151232677 0.717956643904429 LAMB1/ADGRG1/RTN4 3 GO:0045047 protein targeting to ER 3/896 42/18722 0.326043151232677 0.717956643904429 TRAM2/SEC63/HSPA5 3 GO:0045292 mRNA cis splicing, via spliceosome 3/896 42/18722 0.326043151232677 0.717956643904429 PSIP1/RBM17/PRPF40A 3 GO:0046688 response to copper ion 3/896 42/18722 0.326043151232677 0.717956643904429 CDK1/APP/MT2A 3 GO:0060999 positive regulation of dendritic spine development 3/896 42/18722 0.326043151232677 0.717956643904429 PPP1R9A/DLG5/FMR1 3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 3/896 42/18722 0.326043151232677 0.717956643904429 EXOSC8/DCP2/CNOT1 3 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 3/896 42/18722 0.326043151232677 0.717956643904429 TEAD1/KLF5/SMARCA4 3 GO:2001222 regulation of neuron migration 3/896 42/18722 0.326043151232677 0.717956643904429 KIF20B/ADGRG1/SEMA6A 3 GO:0009743 response to carbohydrate 14/896 253/18722 0.326849011732181 0.718878921605818 COLEC12/SLC29A1/GJA1/CTSV/IGF1R/CDT1/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 14 GO:0006023 aminoglycan biosynthetic process 5/896 79/18722 0.327214892469511 0.718878921605818 HS6ST2/GCNT2/CHST14/CHPF/CLTC 5 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 5/896 79/18722 0.327214892469511 0.718878921605818 PRKDC/NRP1/P4HB/CALR/TRIOBP 5 GO:0050772 positive regulation of axonogenesis 5/896 79/18722 0.327214892469511 0.718878921605818 NRP1/PLXNB1/GOLGA4/MACF1/LRP1 5 GO:1901184 regulation of ERBB signaling pathway 5/896 79/18722 0.327214892469511 0.718878921605818 EGFR/DGKD/SNX5/RBPJ/RTN4 5 GO:0045862 positive regulation of proteolysis 20/896 372/18722 0.327992529128127 0.720127565054932 HMGB1/AURKA/APP/CDC20/PERP/ASPH/PLK1/CASP8AP2/ROCK2/TMTC3/FBLN1/FBXO22/RNF217/HSPD1/FMR1/HDAC2/ANP32B/PCOLCE2/CLDN4/PSMD14 20 GO:0043502 regulation of muscle adaptation 6/896 98/18722 0.328299699363273 0.720127565054932 DAG1/PARP1/PARP2/ATP2A2/ROCK2/CAMK2G 6 GO:0046942 carboxylic acid transport 15/896 273/18722 0.328386616909214 0.720127565054932 LRP2/ITGB1/SLC38A1/GJA1/SFXN1/SLC16A1/SLC26A2/SLC16A12/ARL6IP1/SLC35D1/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC13A3 15 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 15/896 273/18722 0.328386616909214 0.720127565054932 CDH1/DSC3/DSG2/TENM3/CADM1/ITGB1/FAT1/CLSTN1/DSC2/PTPRM/PALLD/PCDH11X/CLDN4/CLDN7/BSG 15 GO:0052548 regulation of endopeptidase activity 23/896 432/18722 0.328820841797224 0.720572953580211 HMGB1/PTTG1/BIRC5/APLP2/ITIH5/APP/PERP/ASPH/DHCR24/CASP8AP2/CRIM1/ROCK2/ARL6IP1/BCL2L12/SPINT1/SPINT2/HSPD1/ANP32B/SERPINH1/USP14/USP47/SERPINF1/PSMD14 23 GO:0003012 muscle system process 24/896 452/18722 0.328891593182086 0.720572953580211 DSP/ATP2B1/DSG2/DAG1/EZH2/PARP1/ASPH/GJA5/GJA1/ATP1A1/PARP2/NUP155/DLG1/CALM2/UTRN/ATP2A2/DSC2/ROCK2/AKAP9/CAMK2G/CALD1/HDAC2/PABPN1/MYOF 24 GO:1901605 alpha-amino acid metabolic process 11/896 195/18722 0.33154508923303 0.726053328439672 DHFR/GLDC/ARHGAP11B/GMPS/PLOD2/MTR/GCLM/PPAT/MTAP/GFPT1/RIMKLB 11 GO:0009165 nucleotide biosynthetic process 14/896 254/18722 0.332102284013049 0.726940075139063 TYMS/RRM1/DUT/PARP1/DTYMK/RRM2/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/IDH2/TECR 14 GO:0008203 cholesterol metabolic process 8/896 137/18722 0.333611618114356 0.72878204527425 APP/LBR/DHCR24/LRP5/VLDLR/FDPS/SQLE/LIMA1 8 GO:0010977 negative regulation of neuron projection development 8/896 137/18722 0.333611618114356 0.72878204527425 NRP1/SEMA6D/KANK1/SEMA6A/RYK/HDAC2/LRP1/RTN4 8 GO:0030879 mammary gland development 8/896 137/18722 0.333611618114356 0.72878204527425 BRCA2/SLC29A1/LRP5/CCND1/PPAT/ARHGAP5/PRLR/RTN4 8 GO:0045471 response to ethanol 8/896 137/18722 0.333611618114356 0.72878204527425 TYMS/CDK1/GGH/EPS8/CCND1/DNMT3A/HDAC2/PSMD14 8 GO:0030199 collagen fibril organization 4/896 61/18722 0.334162399880515 0.72878204527425 COL14A1/NF1/COL5A2/SERPINH1 4 GO:0043966 histone H3 acetylation 4/896 61/18722 0.334162399880515 0.72878204527425 BRCA2/BRCA1/CHEK1/ZNF451 4 GO:0071384 cellular response to corticosteroid stimulus 4/896 61/18722 0.334162399880515 0.72878204527425 EGFR/ATP2B1/HNRNPU/SERPINF1 4 GO:0022612 gland morphogenesis 7/896 118/18722 0.335608293026357 0.72878204527425 DAG1/BMP7/NRP1/LAMA5/LRP5/NFIB/TGM2 7 GO:0015711 organic anion transport 19/896 354/18722 0.33637394230066 0.72878204527425 LRP2/SLC29A1/ITGB1/SLC38A1/GJA1/SLC35B4/SFXN1/SLC16A1/SLC26A2/SLC16A12/ARL6IP1/SLC35D1/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC2A1/SLC13A3/SLC25A5 19 GO:0003300 cardiac muscle hypertrophy 6/896 99/18722 0.336849655641345 0.72878204527425 EZH2/PARP1/PARP2/ATP2A2/ROCK2/HDAC2 6 GO:0021510 spinal cord development 6/896 99/18722 0.336849655641345 0.72878204527425 SUZ12/PKD2/SOX4/NF1/VLDLR/LMO4 6 GO:0043547 positive regulation of GTPase activity 14/896 255/18722 0.337374507216708 0.72878204527425 ITGA6/ECT2/EZH2/ARHGAP11A/ITGB1/SYDE2/ADRB1/NF1/DOCK9/PLXNB1/NET1/ASAP1/RASA1/TGM2 14 GO:0010560 positive regulation of glycoprotein biosynthetic process 2/896 25/18722 0.337828794761608 0.72878204527425 PAWR/ALG10B 2 GO:0010842 retina layer formation 2/896 25/18722 0.337828794761608 0.72878204527425 PTPRM/AHI1 2 GO:0010996 response to auditory stimulus 2/896 25/18722 0.337828794761608 0.72878204527425 CNTNAP2/USP53 2 GO:0015012 heparan sulfate proteoglycan biosynthetic process 2/896 25/18722 0.337828794761608 0.72878204527425 HS6ST2/EXTL2 2 GO:0031579 membrane raft organization 2/896 25/18722 0.337828794761608 0.72878204527425 EMP2/DLG1 2 GO:0033233 regulation of protein sumoylation 2/896 25/18722 0.337828794761608 0.72878204527425 SAE1/UBA2 2 GO:0033622 integrin activation 2/896 25/18722 0.337828794761608 0.72878204527425 KIF14/FERMT1 2 GO:0034389 lipid droplet organization 2/896 25/18722 0.337828794761608 0.72878204527425 CDS1/SQLE 2 GO:0045822 negative regulation of heart contraction 2/896 25/18722 0.337828794761608 0.72878204527425 ATP1A1/ATP2A2 2 GO:0046949 fatty-acyl-CoA biosynthetic process 2/896 25/18722 0.337828794761608 0.72878204527425 SLC25A1/TECR 2 GO:0048596 embryonic camera-type eye morphogenesis 2/896 25/18722 0.337828794761608 0.72878204527425 BMP7/FZD5 2 GO:0051307 meiotic chromosome separation 2/896 25/18722 0.337828794761608 0.72878204527425 TOP2A/TTK 2 GO:0051450 myoblast proliferation 2/896 25/18722 0.337828794761608 0.72878204527425 MEIS2/PAXBP1 2 GO:0060074 synapse maturation 2/896 25/18722 0.337828794761608 0.72878204527425 CDC20/CLSTN1 2 GO:0071450 cellular response to oxygen radical 2/896 25/18722 0.337828794761608 0.72878204527425 BMP7/DHFR 2 GO:0071451 cellular response to superoxide 2/896 25/18722 0.337828794761608 0.72878204527425 BMP7/DHFR 2 GO:0072202 cell differentiation involved in metanephros development 2/896 25/18722 0.337828794761608 0.72878204527425 YAP1/LGR4 2 GO:1903792 negative regulation of anion transport 2/896 25/18722 0.337828794761608 0.72878204527425 GABRE/GOPC 2 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/896 25/18722 0.337828794761608 0.72878204527425 EGFR/LIN28B 2 GO:1905048 regulation of metallopeptidase activity 2/896 25/18722 0.337828794761608 0.72878204527425 LRP1/CLDN4 2 GO:0043270 positive regulation of ion transport 15/896 275/18722 0.338531309637798 0.729055876303645 ATP2B1/TCAF1/ITGB1/ANK3/PKD2/ALG10B/DLG1/SLC6A4/CALM2/ARL6IP1/AHCYL1/AKAP9/KIF5B/ATP1B3/ANO6 15 GO:0006509 membrane protein ectodomain proteolysis 3/896 43/18722 0.339330154408609 0.729055876303645 DAG1/RBMX/SPPL2A 3 GO:0014014 negative regulation of gliogenesis 3/896 43/18722 0.339330154408609 0.729055876303645 NF1/DICER1/IDH2 3 GO:0016266 O-glycan processing 3/896 43/18722 0.339330154408609 0.729055876303645 GALNT11/GXYLT1/C1GALT1 3 GO:0031952 regulation of protein autophosphorylation 3/896 43/18722 0.339330154408609 0.729055876303645 CALM2/IQGAP1/RAD50 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/896 43/18722 0.339330154408609 0.729055876303645 BRCA2/MSH2/TMEM109 3 GO:0045776 negative regulation of blood pressure 3/896 43/18722 0.339330154408609 0.729055876303645 GJA5/ADRB1/SNX5 3 GO:0098927 vesicle-mediated transport between endosomal compartments 3/896 43/18722 0.339330154408609 0.729055876303645 EMP2/RDX/EEA1 3 GO:1903793 positive regulation of anion transport 3/896 43/18722 0.339330154408609 0.729055876303645 TCAF1/ITGB1/ARL6IP1 3 GO:0098739 import across plasma membrane 10/896 177/18722 0.341154039806968 0.732644798037996 LRP2/SLC39A10/ITGB1/ATP1A1/DLG1/SLC5A3/ARL6IP1/SLC1A5/ATP1B3/SLC2A1 10 GO:1903522 regulation of blood circulation 14/896 256/18722 0.342664616284226 0.735557948804359 DSP/EGFR/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/NUP155/ADRB1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 14 GO:0009116 nucleoside metabolic process 4/896 62/18722 0.345162269706487 0.740253672766743 TK1/DTYMK/PPAT/MTAP 4 GO:0046847 filopodium assembly 4/896 62/18722 0.345162269706487 0.740253672766743 NRP1/ITGB4/PPP1R9A/FMR1 4 GO:0021954 central nervous system neuron development 5/896 81/18722 0.346339898089972 0.742112510539285 NRP2/HSP90AA1/NRP1/NFIB/HSP90AB1 5 GO:0048708 astrocyte differentiation 5/896 81/18722 0.346339898089972 0.742112510539285 EGFR/APP/NF1/CDK6/LRP1 5 GO:0009266 response to temperature stimulus 10/896 178/18722 0.347544139092246 0.744358779733685 ATP2B1/HSP90AA1/PSIP1/ADRB1/TPR/ATP2A2/HSPD1/HDAC2/RBBP7/HSP90AB1 10 GO:0030216 keratinocyte differentiation 8/896 139/18722 0.348097976368161 0.744876619982789 DSP/EXPH5/ROCK2/YAP1/PALLD/ST14/RBPJ/NCOA3 8 GO:0045598 regulation of fat cell differentiation 8/896 139/18722 0.348097976368161 0.744876619982789 BMP7/LRP5/CDS1/KLF5/YAP1/ASXL1/HNRNPU/ADIRF 8 GO:0045088 regulation of innate immune response 12/896 218/18722 0.351276586810272 0.749937930066955 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/SFPQ/DHX9/PSPC1/NONO/XRCC5/XRCC6/HSP90AB1 12 GO:0050803 regulation of synapse structure or activity 12/896 218/18722 0.351276586810272 0.749937930066955 TUBB/NRP2/APP/DAG1/CDC20/TPBG/CLSTN1/PPP1R9A/DLG5/NEDD4/EIF4G1/HSPA8 12 GO:0072655 establishment of protein localization to mitochondrion 7/896 120/18722 0.351276989788268 0.749937930066955 HSP90AA1/LMAN1/FZD5/SAE1/NPEPPS/HUWE1/HSPD1 7 GO:0051259 protein complex oligomerization 13/896 238/18722 0.352450896283521 0.749937930066955 RRM1/FUS/ECT2/TK1/RRM2/POLQ/BLM/PKD2/KCTD3/RBMX/CEP57/SLC1A5/TRPM7 13 GO:0021517 ventral spinal cord development 3/896 44/18722 0.35259909664705 0.749937930066955 SOX4/VLDLR/LMO4 3 GO:0031295 T cell costimulation 3/896 44/18722 0.35259909664705 0.749937930066955 DPP4/YES1/CD24 3 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 3/896 44/18722 0.35259909664705 0.749937930066955 CENPJ/PRLR/OCIAD1 3 GO:0048806 genitalia development 3/896 44/18722 0.35259909664705 0.749937930066955 LRP2/DHCR24/LGR4 3 GO:0060324 face development 3/896 44/18722 0.35259909664705 0.749937930066955 CRISPLD1/ANKRD11/PLEKHA1 3 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 3/896 44/18722 0.35259909664705 0.749937930066955 HMGB1/PUM1/RTN4 3 GO:0089718 amino acid import across plasma membrane 3/896 44/18722 0.35259909664705 0.749937930066955 ITGB1/ARL6IP1/SLC1A5 3 GO:1903573 negative regulation of response to endoplasmic reticulum stress 3/896 44/18722 0.35259909664705 0.749937930066955 HSPA5/USP14/UFL1 3 GO:0007626 locomotory behavior 10/896 179/18722 0.353952972720611 0.749937930066955 APP/DPP4/MCOLN3/EPS8/ZFHX3/VPS13A/OXR1/ANKH/PUM1/HEXB 10 GO:0051963 regulation of synapse assembly 6/896 101/18722 0.354018378538697 0.749937930066955 APP/TPBG/CLSTN1/PPP1R9A/DLG5/EIF4G1 6 GO:0001573 ganglioside metabolic process 2/896 26/18722 0.355490057759011 0.749937930066955 ITGB8/HEXB 2 GO:0002092 positive regulation of receptor internalization 2/896 26/18722 0.355490057759011 0.749937930066955 AHI1/FMR1 2 GO:0002418 immune response to tumor cell 2/896 26/18722 0.355490057759011 0.749937930066955 HMGB1/HSPD1 2 GO:0006027 glycosaminoglycan catabolic process 2/896 26/18722 0.355490057759011 0.749937930066955 GUSB/GLB1 2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 2/896 26/18722 0.355490057759011 0.749937930066955 TRAM2/SEC63 2 GO:0006706 steroid catabolic process 2/896 26/18722 0.355490057759011 0.749937930066955 YWHAH/STS 2 GO:0018027 peptidyl-lysine dimethylation 2/896 26/18722 0.355490057759011 0.749937930066955 SETD2/ASH1L 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/896 26/18722 0.355490057759011 0.749937930066955 MASTL/ROCK2 2 GO:0033522 histone H2A ubiquitination 2/896 26/18722 0.355490057759011 0.749937930066955 RNF168/DDB1 2 GO:0034114 regulation of heterotypic cell-cell adhesion 2/896 26/18722 0.355490057759011 0.749937930066955 BMP7/GCNT2 2 GO:0043501 skeletal muscle adaptation 2/896 26/18722 0.355490057759011 0.749937930066955 ATP2A2/CAMK2G 2 GO:0051560 mitochondrial calcium ion homeostasis 2/896 26/18722 0.355490057759011 0.749937930066955 AFG3L2/TGM2 2 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/896 26/18722 0.355490057759011 0.749937930066955 PKD2/CALM2 2 GO:0070193 synaptonemal complex organization 2/896 26/18722 0.355490057759011 0.749937930066955 RAD21/PLK1 2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/896 26/18722 0.355490057759011 0.749937930066955 EGFR/LIN28B 2 GO:0072273 metanephric nephron morphogenesis 2/896 26/18722 0.355490057759011 0.749937930066955 PKD2/LGR4 2 GO:1902186 regulation of viral release from host cell 2/896 26/18722 0.355490057759011 0.749937930066955 TRIM28/DDB1 2 GO:1903523 negative regulation of blood circulation 2/896 26/18722 0.355490057759011 0.749937930066955 ATP1A1/ATP2A2 2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 5/896 82/18722 0.355929444962424 0.750375242026402 FEN1/RNASEH2A/AGO2/DICER1/RPS21 5 GO:0001756 somitogenesis 4/896 63/18722 0.356168893680734 0.750375242026402 PRKDC/XRCC2/COBL/RBPJ 4 GO:0022617 extracellular matrix disassembly 4/896 63/18722 0.356168893680734 0.750375242026402 LAMC1/DPP4/CTSV/LRP1 4 GO:0009746 response to hexose 12/896 219/18722 0.357077821184517 0.751958323041414 SLC29A1/GJA1/CTSV/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 12 GO:0051346 negative regulation of hydrolase activity 20/896 379/18722 0.358600857758191 0.754832669725575 PTTG1/BIRC5/APLP2/ITIH5/APP/DHCR24/AMOT/MASTL/CRIM1/ROCK2/ARL6IP1/RDX/BCL2L12/SPINT1/SPINT2/LRP1/SERPINH1/USP14/USP47/SERPINF1 20 GO:0038127 ERBB signaling pathway 7/896 121/18722 0.359140427073957 0.75516076410269 EFEMP1/EGFR/DGKD/SNX5/IQGAP1/RBPJ/RTN4 7 GO:0043500 muscle adaptation 7/896 121/18722 0.359140427073957 0.75516076410269 DAG1/EZH2/PARP1/PARP2/ATP2A2/ROCK2/CAMK2G 7 GO:0008202 steroid metabolic process 17/896 319/18722 0.359231272575871 0.75516076410269 LRP2/SLC27A2/APP/LBR/DHCR24/ATP1A1/LRP5/YWHAH/PBX1/VLDLR/SF1/PRLR/STS/FDPS/PLEKHA1/SQLE/LIMA1 17 GO:0048660 regulation of smooth muscle cell proliferation 10/896 180/18722 0.360378666510978 0.757239328311359 PRKDC/EGFR/GJA1/ADAMTS1/SKP2/DNMT1/SF1/XRCC5/XRCC6/TGM2 10 GO:0014897 striated muscle hypertrophy 6/896 102/18722 0.362628156889141 0.760700000429988 EZH2/PARP1/PARP2/ATP2A2/ROCK2/HDAC2 6 GO:1990542 mitochondrial transmembrane transport 6/896 102/18722 0.362628156889141 0.760700000429988 SFXN1/SLC25A36/SLC25A1/AFG3L2/HSPD1/SLC25A5 6 GO:0035296 regulation of tube diameter 8/896 141/18722 0.362663008164779 0.760700000429988 EGFR/ATP2B1/GJA5/GJA1/ADRB1/SLC6A4/GCLM/ROCK2 8 GO:0097746 blood vessel diameter maintenance 8/896 141/18722 0.362663008164779 0.760700000429988 EGFR/ATP2B1/GJA5/GJA1/ADRB1/SLC6A4/GCLM/ROCK2 8 GO:0048705 skeletal system morphogenesis 12/896 220/18722 0.362894034124083 0.760850293767401 FBN2/BMP7/LRP5/DLG1/ANKRD11/GLG1/SETD2/RYK/PLEKHA1/SLC39A1/TRIP11/SERPINH1 12 GO:0031397 negative regulation of protein ubiquitination 5/896 83/18722 0.365528872117983 0.764331591636741 MAD2L1/FBXO5/SOX4/UFL1/TRIM44 5 GO:0051899 membrane depolarization 5/896 83/18722 0.365528872117983 0.764331591636741 PARP1/GJA5/ANK3/YWHAH/GCLM 5 GO:1901292 nucleoside phosphate catabolic process 5/896 83/18722 0.365528872117983 0.764331591636741 DUT/NUDT15/UNG/HINT1/NUDT4 5 GO:0022602 ovulation cycle process 3/896 45/18722 0.365835292603677 0.764331591636741 ADAMTS1/HSPA5/PLEKHA1 3 GO:0030850 prostate gland development 3/896 45/18722 0.365835292603677 0.764331591636741 BMP7/SMARCC1/SERPINF1 3 GO:0035384 thioester biosynthetic process 3/896 45/18722 0.365835292603677 0.764331591636741 SLC25A1/ACSS1/TECR 3 GO:0042551 neuron maturation 3/896 45/18722 0.365835292603677 0.764331591636741 APP/CNTNAP2/NRCAM 3 GO:0071616 acyl-CoA biosynthetic process 3/896 45/18722 0.365835292603677 0.764331591636741 SLC25A1/ACSS1/TECR 3 GO:0016126 sterol biosynthetic process 4/896 64/18722 0.367173364582603 0.764453199627563 LBR/DHCR24/FDPS/SQLE 4 GO:0030104 water homeostasis 4/896 64/18722 0.367173364582603 0.764453199627563 STMN1/MET/LSR/CLDN4 4 GO:0098930 axonal transport 4/896 64/18722 0.367173364582603 0.764453199627563 KIF4A/DST/DYNC1H1/KIF5B 4 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/896 64/18722 0.367173364582603 0.764453199627563 PBK/SMARCC1/USP14/HSP90AB1 4 GO:0060047 heart contraction 13/896 241/18722 0.369157607553407 0.764453199627563 DSP/ATP2B1/DSG2/GJA5/GJA1/ATP1A1/NUP155/ADRB1/DLG1/CALM2/ATP2A2/DSC2/AKAP9 13 GO:0035150 regulation of tube size 8/896 142/18722 0.369968220390132 0.764453199627563 EGFR/ATP2B1/GJA5/GJA1/ADRB1/SLC6A4/GCLM/ROCK2 8 GO:0032760 positive regulation of tumor necrosis factor production 6/896 103/18722 0.371248994562655 0.764453199627563 HMGB1/APP/FZD5/DHX9/HSPD1/HDAC2 6 GO:0090277 positive regulation of peptide hormone secretion 6/896 103/18722 0.371248994562655 0.764453199627563 EGFR/GJA1/SOX4/TM7SF3/KIF5B/LRP1 6 GO:0000469 cleavage involved in rRNA processing 2/896 27/18722 0.372979469185785 0.764453199627563 EXOSC8/RPS21 2 GO:0003171 atrioventricular valve development 2/896 27/18722 0.372979469185785 0.764453199627563 GJA5/SOX4 2 GO:0003272 endocardial cushion formation 2/896 27/18722 0.372979469185785 0.764453199627563 BMP7/RBPJ 2 GO:0003401 axis elongation 2/896 27/18722 0.372979469185785 0.764453199627563 YAP1/TRIM28 2 GO:0008053 mitochondrial fusion 2/896 27/18722 0.372979469185785 0.764453199627563 AFG3L2/HUWE1 2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 2/896 27/18722 0.372979469185785 0.764453199627563 CALM2/ATP2A2 2 GO:0015813 L-glutamate transmembrane transport 2/896 27/18722 0.372979469185785 0.764453199627563 ITGB1/ARL6IP1 2 GO:0032967 positive regulation of collagen biosynthetic process 2/896 27/18722 0.372979469185785 0.764453199627563 SUCO/HDAC2 2 GO:0042104 positive regulation of activated T cell proliferation 2/896 27/18722 0.372979469185785 0.764453199627563 HMGB1/CD24 2 GO:0042402 cellular biogenic amine catabolic process 2/896 27/18722 0.372979469185785 0.764453199627563 SLC44A1/ALDH7A1 2 GO:0045830 positive regulation of isotype switching 2/896 27/18722 0.372979469185785 0.764453199627563 RIF1/MSH2 2 GO:0048520 positive regulation of behavior 2/896 27/18722 0.372979469185785 0.764453199627563 GJA1/HDAC2 2 GO:0070861 regulation of protein exit from endoplasmic reticulum 2/896 27/18722 0.372979469185785 0.764453199627563 TMEM30B/UBE2G2 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/896 27/18722 0.372979469185785 0.764453199627563 GJA5/AKAP9 2 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 2/896 27/18722 0.372979469185785 0.764453199627563 SEMA6A/MYO1C 2 GO:1902883 negative regulation of response to oxidative stress 2/896 27/18722 0.372979469185785 0.764453199627563 MET/OXR1 2 GO:1902914 regulation of protein polyubiquitination 2/896 27/18722 0.372979469185785 0.764453199627563 SKP2/TRIM44 2 GO:1903205 regulation of hydrogen peroxide-induced cell death 2/896 27/18722 0.372979469185785 0.764453199627563 MET/PAWR 2 GO:0051260 protein homooligomerization 10/896 182/18722 0.373273173233097 0.764453199627563 FUS/ECT2/TK1/POLQ/BLM/PKD2/KCTD3/RBMX/CEP57/SLC1A5 10 GO:0016051 carbohydrate biosynthetic process 11/896 202/18722 0.374101668652219 0.764453199627563 AGL/SLC35B4/FUT8/SOGA1/CHST14/PGP/SLC25A1/RANBP2/CLTC/DDB1/ISYNA1 11 GO:0042310 vasoconstriction 5/896 84/18722 0.375132230363028 0.764453199627563 EGFR/ATP2B1/GJA5/GJA1/SLC6A4 5 GO:0006865 amino acid transport 8/896 143/18722 0.377284977431201 0.764453199627563 ITGB1/SLC38A1/GJA1/SFXN1/ARL6IP1/SLC38A2/SLC1A5/SLC7A6 8 GO:0003170 heart valve development 4/896 65/18722 0.37816706439996 0.764453199627563 GJA5/SOX4/ROCK2/RBPJ 4 GO:0045682 regulation of epidermis development 4/896 65/18722 0.37816706439996 0.764453199627563 EZH2/ESRP1/ROCK2/NCOA3 4 GO:0060389 pathway-restricted SMAD protein phosphorylation 4/896 65/18722 0.37816706439996 0.764453199627563 BMP7/TTK/TGFBR3/LRP1 4 GO:0071677 positive regulation of mononuclear cell migration 4/896 65/18722 0.37816706439996 0.764453199627563 HMGB1/APP/CALR/ANO6 4 GO:0006195 purine nucleotide catabolic process 3/896 46/18722 0.379024830413728 0.764453199627563 NUDT15/HINT1/NUDT4 3 GO:0006383 transcription by RNA polymerase III 3/896 46/18722 0.379024830413728 0.764453199627563 BDP1/ICE1/POLR2L 3 GO:0006984 ER-nucleus signaling pathway 3/896 46/18722 0.379024830413728 0.764453199627563 ATP2A2/CCDC47/HSPA5 3 GO:0031018 endocrine pancreas development 3/896 46/18722 0.379024830413728 0.764453199627563 SOX4/CDK6/RHEB 3 GO:0031294 lymphocyte costimulation 3/896 46/18722 0.379024830413728 0.764453199627563 DPP4/YES1/CD24 3 GO:0043462 regulation of ATPase activity 3/896 46/18722 0.379024830413728 0.764453199627563 DNAJC9/ATP1B3/DNAJB11 3 GO:0072599 establishment of protein localization to endoplasmic reticulum 3/896 46/18722 0.379024830413728 0.764453199627563 TRAM2/SEC63/HSPA5 3 GO:1900271 regulation of long-term synaptic potentiation 3/896 46/18722 0.379024830413728 0.764453199627563 APP/MME/PPP1R9A 3 GO:0007162 negative regulation of cell adhesion 16/896 303/18722 0.379192995730494 0.764453199627563 HMGB1/CDH1/KANK1/PAWR/SEMA6A/DLG1/GCNT2/CDKN2A/RDX/DLG5/FBLN1/PLXNB1/SPINT2/TACSTD2/LRP1/RASA1 16 GO:0006892 post-Golgi vesicle-mediated transport 6/896 104/18722 0.379876564822087 0.764453199627563 SPTBN1/ANK3/VPS13A/GOLGA4/MACF1/GOPC 6 GO:0014896 muscle hypertrophy 6/896 104/18722 0.379876564822087 0.764453199627563 EZH2/PARP1/PARP2/ATP2A2/ROCK2/HDAC2 6 GO:0032963 collagen metabolic process 6/896 104/18722 0.379876564822087 0.764453199627563 ITGB1/SUCO/TRAM2/HDAC2/SERPINH1/CTSL 6 GO:0048661 positive regulation of smooth muscle cell proliferation 6/896 104/18722 0.379876564822087 0.764453199627563 EGFR/GJA1/ADAMTS1/SKP2/DNMT1/TGM2 6 GO:1901890 positive regulation of cell junction assembly 6/896 104/18722 0.379876564822087 0.764453199627563 NRP1/TPBG/CLSTN1/CNTNAP2/DLG5/IQGAP1 6 GO:0060541 respiratory system development 11/896 203/18722 0.380238188034253 0.764453199627563 HMGB1/EGFR/MME/DAG1/LAMA5/NFIB/YAP1/DLG5/ASXL1/HSPB11/RBPJ 11 GO:0032092 positive regulation of protein binding 5/896 85/18722 0.384733707920357 0.764453199627563 APP/NRP1/RAN/LRP1/HSP90AB1 5 GO:0048659 smooth muscle cell proliferation 10/896 184/18722 0.386212827651987 0.764453199627563 PRKDC/EGFR/GJA1/ADAMTS1/SKP2/DNMT1/SF1/XRCC5/XRCC6/TGM2 10 GO:2001257 regulation of cation channel activity 10/896 184/18722 0.386212827651987 0.764453199627563 APP/ITGB1/ANK3/PKD2/ALG10B/DLG1/CALM2/KIF5B/FMR1/AHNAK 10 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA 1/896 10/18722 0.387700187989826 0.764453199627563 DCP2 1 GO:0001553 luteinization 1/896 10/18722 0.387700187989826 0.764453199627563 PLEKHA1 1 GO:0001820 serotonin secretion 1/896 10/18722 0.387700187989826 0.764453199627563 SLC6A4 1 GO:0003056 regulation of vascular associated smooth muscle contraction 1/896 10/18722 0.387700187989826 0.764453199627563 ATP2B1 1 GO:0003183 mitral valve morphogenesis 1/896 10/18722 0.387700187989826 0.764453199627563 SOX4 1 GO:0006012 galactose metabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 GLB1 1 GO:0006283 transcription-coupled nucleotide-excision repair 1/896 10/18722 0.387700187989826 0.764453199627563 HMGN1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/896 10/18722 0.387700187989826 0.764453199627563 DTYMK 1 GO:0009396 folic acid-containing compound biosynthetic process 1/896 10/18722 0.387700187989826 0.764453199627563 DHFR 1 GO:0010172 embryonic body morphogenesis 1/896 10/18722 0.387700187989826 0.764453199627563 DAG1 1 GO:0010968 regulation of microtubule nucleation 1/896 10/18722 0.387700187989826 0.764453199627563 CKAP5 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/896 10/18722 0.387700187989826 0.764453199627563 SLC2A1 1 GO:0017085 response to insecticide 1/896 10/18722 0.387700187989826 0.764453199627563 CCNB1 1 GO:0019062 virion attachment to host cell 1/896 10/18722 0.387700187989826 0.764453199627563 HSP90AB1 1 GO:0019532 oxalate transport 1/896 10/18722 0.387700187989826 0.764453199627563 SLC26A2 1 GO:0030638 polyketide metabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 AKR7A2 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 AKR7A2 1 GO:0031340 positive regulation of vesicle fusion 1/896 10/18722 0.387700187989826 0.764453199627563 KIF5B 1 GO:0031915 positive regulation of synaptic plasticity 1/896 10/18722 0.387700187989826 0.764453199627563 CDC20 1 GO:0031943 regulation of glucocorticoid metabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 ATP1A1 1 GO:0032025 response to cobalt ion 1/896 10/18722 0.387700187989826 0.764453199627563 SERPINF1 1 GO:0032253 dense core granule localization 1/896 10/18722 0.387700187989826 0.764453199627563 KIF5B 1 GO:0033131 regulation of glucokinase activity 1/896 10/18722 0.387700187989826 0.764453199627563 RANBP2 1 GO:0033572 transferrin transport 1/896 10/18722 0.387700187989826 0.764453199627563 CLTC 1 GO:0034085 establishment of sister chromatid cohesion 1/896 10/18722 0.387700187989826 0.764453199627563 CDCA5 1 GO:0035376 sterol import 1/896 10/18722 0.387700187989826 0.764453199627563 LRP1 1 GO:0035907 dorsal aorta development 1/896 10/18722 0.387700187989826 0.764453199627563 RBPJ 1 GO:0035999 tetrahydrofolate interconversion 1/896 10/18722 0.387700187989826 0.764453199627563 TYMS 1 GO:0040015 negative regulation of multicellular organism growth 1/896 10/18722 0.387700187989826 0.764453199627563 ADRB1 1 GO:0042045 epithelial fluid transport 1/896 10/18722 0.387700187989826 0.764453199627563 AHCYL1 1 GO:0042996 regulation of Golgi to plasma membrane protein transport 1/896 10/18722 0.387700187989826 0.764453199627563 GOPC 1 GO:0043101 purine-containing compound salvage 1/896 10/18722 0.387700187989826 0.764453199627563 MTAP 1 GO:0044598 doxorubicin metabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 AKR7A2 1 GO:0044848 biological phase 1/896 10/18722 0.387700187989826 0.764453199627563 FERMT1 1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence 1/896 10/18722 0.387700187989826 0.764453199627563 EMC1 1 GO:0045792 negative regulation of cell size 1/896 10/18722 0.387700187989826 0.764453199627563 RDX 1 GO:0045835 negative regulation of meiotic nuclear division 1/896 10/18722 0.387700187989826 0.764453199627563 FBXO5 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/896 10/18722 0.387700187989826 0.764453199627563 HMGB1 1 GO:0048241 epinephrine transport 1/896 10/18722 0.387700187989826 0.764453199627563 LY6E 1 GO:0048672 positive regulation of collateral sprouting 1/896 10/18722 0.387700187989826 0.764453199627563 LRP1 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/896 10/18722 0.387700187989826 0.764453199627563 SLC39A10 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/896 10/18722 0.387700187989826 0.764453199627563 CALM2 1 GO:0051351 positive regulation of ligase activity 1/896 10/18722 0.387700187989826 0.764453199627563 GCLM 1 GO:0060068 vagina development 1/896 10/18722 0.387700187989826 0.764453199627563 LRP2 1 GO:0060272 embryonic skeletal joint morphogenesis 1/896 10/18722 0.387700187989826 0.764453199627563 BMP7 1 GO:0060513 prostatic bud formation 1/896 10/18722 0.387700187989826 0.764453199627563 BMP7 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/896 10/18722 0.387700187989826 0.764453199627563 SERPINF1 1 GO:0060923 cardiac muscle cell fate commitment 1/896 10/18722 0.387700187989826 0.764453199627563 RBPJ 1 GO:0061085 regulation of histone H3-K27 methylation 1/896 10/18722 0.387700187989826 0.764453199627563 MTF2 1 GO:0061140 lung secretory cell differentiation 1/896 10/18722 0.387700187989826 0.764453199627563 NFIB 1 GO:0070508 cholesterol import 1/896 10/18722 0.387700187989826 0.764453199627563 LRP1 1 GO:0070561 vitamin D receptor signaling pathway 1/896 10/18722 0.387700187989826 0.764453199627563 TRIM24 1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/896 10/18722 0.387700187989826 0.764453199627563 UBE2G2 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/896 10/18722 0.387700187989826 0.764453199627563 GCLM 1 GO:0071421 manganese ion transmembrane transport 1/896 10/18722 0.387700187989826 0.764453199627563 TMEM165 1 GO:0071803 positive regulation of podosome assembly 1/896 10/18722 0.387700187989826 0.764453199627563 ASAP1 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/896 10/18722 0.387700187989826 0.764453199627563 BMP7 1 GO:0072178 nephric duct morphogenesis 1/896 10/18722 0.387700187989826 0.764453199627563 AHI1 1 GO:0072203 cell proliferation involved in metanephros development 1/896 10/18722 0.387700187989826 0.764453199627563 BMP7 1 GO:0072378 blood coagulation, fibrin clot formation 1/896 10/18722 0.387700187989826 0.764453199627563 FBLN1 1 GO:0090647 modulation of age-related behavioral decline 1/896 10/18722 0.387700187989826 0.764453199627563 APP 1 GO:0097278 complement-dependent cytotoxicity 1/896 10/18722 0.387700187989826 0.764453199627563 HSP90AB1 1 GO:0098885 modification of postsynaptic actin cytoskeleton 1/896 10/18722 0.387700187989826 0.764453199627563 MYH10 1 GO:0098917 retrograde trans-synaptic signaling 1/896 10/18722 0.387700187989826 0.764453199627563 DAG1 1 GO:0099519 dense core granule cytoskeletal transport 1/896 10/18722 0.387700187989826 0.764453199627563 KIF5B 1 GO:0099532 synaptic vesicle endosomal processing 1/896 10/18722 0.387700187989826 0.764453199627563 EEA1 1 GO:1900246 positive regulation of RIG-I signaling pathway 1/896 10/18722 0.387700187989826 0.764453199627563 PUM1 1 GO:1901203 positive regulation of extracellular matrix assembly 1/896 10/18722 0.387700187989826 0.764453199627563 DAG1 1 GO:1901524 regulation of mitophagy 1/896 10/18722 0.387700187989826 0.764453199627563 SLC25A5 1 GO:1901950 dense core granule transport 1/896 10/18722 0.387700187989826 0.764453199627563 KIF5B 1 GO:1901993 regulation of meiotic cell cycle phase transition 1/896 10/18722 0.387700187989826 0.764453199627563 TTK 1 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1/896 10/18722 0.387700187989826 0.764453199627563 ROCK2 1 GO:1905383 protein localization to presynapse 1/896 10/18722 0.387700187989826 0.764453199627563 KIF5B 1 GO:1990535 neuron projection maintenance 1/896 10/18722 0.387700187989826 0.764453199627563 APP 1 GO:1990700 nucleolar chromatin organization 1/896 10/18722 0.387700187989826 0.764453199627563 SMARCA5 1 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 1/896 10/18722 0.387700187989826 0.764453199627563 OXR1 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/896 10/18722 0.387700187989826 0.764453199627563 CALR 1 GO:2001223 negative regulation of neuron migration 1/896 10/18722 0.387700187989826 0.764453199627563 ADGRG1 1 GO:2001225 regulation of chloride transport 1/896 10/18722 0.387700187989826 0.764453199627563 GABRE 1 GO:0010959 regulation of metal ion transport 21/896 406/18722 0.38856458017002 0.764453199627563 ATP2B1/ITGB1/TSPAN13/GJA1/ATP1A1/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/AHCYL1/NEDD4/AKAP9/CAMK2G/KIF5B/FMR1/ATP1B3/ANO6/AHNAK 21 GO:0019229 regulation of vasoconstriction 4/896 66/18722 0.389141670507843 0.764453199627563 EGFR/ATP2B1/GJA5/GJA1 4 GO:0000303 response to superoxide 2/896 28/18722 0.39027303461014 0.764453199627563 BMP7/DHFR 2 GO:0000423 mitophagy 2/896 28/18722 0.39027303461014 0.764453199627563 HUWE1/SLC25A5 2 GO:0006829 zinc ion transport 2/896 28/18722 0.39027303461014 0.764453199627563 SLC39A10/SLC39A1 2 GO:0007141 male meiosis I 2/896 28/18722 0.39027303461014 0.764453199627563 BRCA2/RAD51C 2 GO:0009065 glutamine family amino acid catabolic process 2/896 28/18722 0.39027303461014 0.764453199627563 ARHGAP11B/PPAT 2 GO:0010460 positive regulation of heart rate 2/896 28/18722 0.39027303461014 0.764453199627563 ADRB1/ATP2A2 2 GO:0010464 regulation of mesenchymal cell proliferation 2/896 28/18722 0.39027303461014 0.764453199627563 LRP5/NFIB 2 GO:0010714 positive regulation of collagen metabolic process 2/896 28/18722 0.39027303461014 0.764453199627563 SUCO/HDAC2 2 GO:0015740 C4-dicarboxylate transport 2/896 28/18722 0.39027303461014 0.764453199627563 SLC1A5/SLC13A3 2 GO:0030262 apoptotic nuclear changes 2/896 28/18722 0.39027303461014 0.764453199627563 TOP2A/DICER1 2 GO:0034123 positive regulation of toll-like receptor signaling pathway 2/896 28/18722 0.39027303461014 0.764453199627563 HMGB1/RTN4 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 2/896 28/18722 0.39027303461014 0.764453199627563 EGFR/SNX5 2 GO:0042983 amyloid precursor protein biosynthetic process 2/896 28/18722 0.39027303461014 0.764453199627563 PAWR/AGO2 2 GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/896 28/18722 0.39027303461014 0.764453199627563 PAWR/AGO2 2 GO:0051894 positive regulation of focal adhesion assembly 2/896 28/18722 0.39027303461014 0.764453199627563 NRP1/IQGAP1 2 GO:0071280 cellular response to copper ion 2/896 28/18722 0.39027303461014 0.764453199627563 APP/MT2A 2 GO:0080111 DNA demethylation 2/896 28/18722 0.39027303461014 0.764453199627563 TRIM28/USP9X 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/896 28/18722 0.39027303461014 0.764453199627563 GJA5/AKAP9 2 GO:1903020 positive regulation of glycoprotein metabolic process 2/896 28/18722 0.39027303461014 0.764453199627563 PAWR/ALG10B 2 GO:0070585 protein localization to mitochondrion 7/896 125/18722 0.390709114198059 0.764453199627563 HSP90AA1/LMAN1/FZD5/SAE1/NPEPPS/HUWE1/HSPD1 7 GO:0032103 positive regulation of response to external stimulus 22/896 427/18722 0.391630953680902 0.764453199627563 HMGB2/HMGB1/PRKDC/MET/EGFR/APP/CADM1/HSP90AA1/NRP1/TPBG/SFPQ/DHX9/PSPC1/CALR/HSPD1/PUM1/ANO6/LRP1/NONO/XRCC5/XRCC6/TGM2 22 GO:0016485 protein processing 12/896 225/18722 0.392151659338381 0.764453199627563 MME/PERP/ENPEP/PARP1/ASPH/DHCR24/PRSS12/BCL2L12/GLG1/CPD/AFG3L2/CTSL 12 GO:0034284 response to monosaccharide 12/896 225/18722 0.392151659338381 0.764453199627563 SLC29A1/GJA1/CTSV/IGF1R/LRP5/SOX4/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1 12 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 3/896 47/18722 0.392154563445309 0.764453199627563 MME/ENPEP/ADRB1 3 GO:0010712 regulation of collagen metabolic process 3/896 47/18722 0.392154563445309 0.764453199627563 ITGB1/SUCO/HDAC2 3 GO:0046677 response to antibiotic 3/896 47/18722 0.392154563445309 0.764453199627563 EZH2/HSP90AA1/HSPA5 3 GO:0050885 neuromuscular process controlling balance 3/896 47/18722 0.392154563445309 0.764453199627563 APP/IGDCC3/HEXB 3 GO:0051489 regulation of filopodium assembly 3/896 47/18722 0.392154563445309 0.764453199627563 NRP1/PPP1R9A/FMR1 3 GO:0072583 clathrin-dependent endocytosis 3/896 47/18722 0.392154563445309 0.764453199627563 DGKD/CANX/CLTC 3 GO:0097028 dendritic cell differentiation 3/896 47/18722 0.392154563445309 0.764453199627563 HMGB1/ITGB8/RBPJ 3 GO:1903170 negative regulation of calcium ion transmembrane transport 3/896 47/18722 0.392154563445309 0.764453199627563 PKD2/CALM2/FMR1 3 GO:0060348 bone development 11/896 205/18722 0.392538171076034 0.764882055640616 FBN1/GJA1/LRP5/GLG1/ASXL1/PLXNB1/VKORC1/BBX/TRIP11/SERPINH1/TGM2 11 GO:0043433 negative regulation of DNA-binding transcription factor activity 10/896 185/18722 0.392694997564967 0.764882055640616 EZH2/BMP7/PKD2/FZD6/CDKN2A/TAF3/ID1/PURA/HDAC2/UFL1 10 GO:0006493 protein O-linked glycosylation 5/896 86/18722 0.394327635811214 0.767123118729721 GALNT11/GXYLT1/GALNT18/TMTC3/C1GALT1 5 GO:1903510 mucopolysaccharide metabolic process 5/896 86/18722 0.394327635811214 0.767123118729721 ITIH5/CHST14/CHPF/GLB1/CLTC 5 GO:2000117 negative regulation of cysteine-type endopeptidase activity 5/896 86/18722 0.394327635811214 0.767123118729721 BIRC5/DHCR24/ARL6IP1/BCL2L12/USP47 5 GO:0009615 response to virus 19/896 367/18722 0.39552459828389 0.769138261591565 STMN1/HSP90AA1/HERC5/ITGB8/SKP2/AKAP1/ILF3/G3BP1/CDK6/DHX9/SETD2/NCBP3/CREBZF/PUM1/FMR1/TRIM44/CCT5/DDX17/HMGA1 19 GO:0006936 muscle contraction 18/896 347/18722 0.396808702596658 0.771321150731452 DSP/ATP2B1/DSG2/ASPH/GJA5/GJA1/ATP1A1/NUP155/DLG1/CALM2/UTRN/ATP2A2/DSC2/ROCK2/AKAP9/CALD1/PABPN1/MYOF 18 GO:0002793 positive regulation of peptide secretion 6/896 106/18722 0.397134975006134 0.771327246004591 EGFR/GJA1/SOX4/TM7SF3/KIF5B/LRP1 6 GO:0035821 modulation of process of other organism 6/896 106/18722 0.397134975006134 0.771327246004591 NUCKS1/DAG1/SMARCA4/FMR1/ANO6/HSPA8 6 GO:0061180 mammary gland epithelium development 4/896 67/18722 0.400089160562899 0.771946683725618 BRCA2/LRP5/CCND1/RTN4 4 GO:0051262 protein tetramerization 5/896 87/18722 0.403908492647705 0.771946683725618 RRM1/TK1/RRM2/PKD2/TRPM7 5 GO:0050679 positive regulation of epithelial cell proliferation 11/896 207/18722 0.404863695305549 0.771946683725618 HMGB2/HMGB1/LAMB1/EGFR/NRP2/LAMC1/NRP1/CCND1/YAP1/ID1/RTN4 11 GO:0032527 protein exit from endoplasmic reticulum 3/896 48/18722 0.405212099545354 0.771946683725618 HSP90B1/TMEM30B/UBE2G2 3 GO:0045912 negative regulation of carbohydrate metabolic process 3/896 48/18722 0.405212099545354 0.771946683725618 SOGA1/PGP/CLTC 3 GO:1903053 regulation of extracellular matrix organization 3/896 48/18722 0.405212099545354 0.771946683725618 DAG1/DPP4/LRP1 3 GO:0010927 cellular component assembly involved in morphogenesis 6/896 107/18722 0.405757551933528 0.771946683725618 DAG1/ITGB1/ITGB4/DICER1/EPB41L3/CSRP2 6 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 6/896 107/18722 0.405757551933528 0.771946683725618 HMGB1/APP/FZD5/DHX9/HSPD1/HDAC2 6 GO:1903034 regulation of response to wounding 9/896 167/18722 0.406287832059085 0.771946683725618 HMGB1/ITGB1/GJA1/KANK1/FERMT1/STK24/ANO6/LRP1/CLDN4 9 GO:0060041 retina development in camera-type eye 8/896 147/18722 0.406614732114471 0.771946683725618 RRM1/ATP2B1/NRP1/LRP5/PTPRM/AHI1/SMARCA4/SERPINF1 8 GO:0000305 response to oxygen radical 2/896 29/18722 0.407349444564411 0.771946683725618 BMP7/DHFR 2 GO:0002068 glandular epithelial cell development 2/896 29/18722 0.407349444564411 0.771946683725618 CDK6/RHEB 2 GO:0002360 T cell lineage commitment 2/896 29/18722 0.407349444564411 0.771946683725618 PRKDC/CTSL 2 GO:0003309 type B pancreatic cell differentiation 2/896 29/18722 0.407349444564411 0.771946683725618 CDK6/RHEB 2 GO:0009310 amine catabolic process 2/896 29/18722 0.407349444564411 0.771946683725618 SLC44A1/ALDH7A1 2 GO:0010390 histone monoubiquitination 2/896 29/18722 0.407349444564411 0.771946683725618 RNF168/DDB1 2 GO:0010955 negative regulation of protein processing 2/896 29/18722 0.407349444564411 0.771946683725618 BCL2L12/GLG1 2 GO:0019082 viral protein processing 2/896 29/18722 0.407349444564411 0.771946683725618 FUT8/CANX 2 GO:0021522 spinal cord motor neuron differentiation 2/896 29/18722 0.407349444564411 0.771946683725618 SOX4/LMO4 2 GO:0021602 cranial nerve morphogenesis 2/896 29/18722 0.407349444564411 0.771946683725618 NRP2/NRP1 2 GO:0030970 retrograde protein transport, ER to cytosol 2/896 29/18722 0.407349444564411 0.771946683725618 HSP90B1/UBE2G2 2 GO:0033028 myeloid cell apoptotic process 2/896 29/18722 0.407349444564411 0.771946683725618 CDKN2A/CTSL 2 GO:0035066 positive regulation of histone acetylation 2/896 29/18722 0.407349444564411 0.771946683725618 BRCA1/BRD7 2 GO:0048679 regulation of axon regeneration 2/896 29/18722 0.407349444564411 0.771946683725618 STK24/LRP1 2 GO:0060969 negative regulation of gene silencing 2/896 29/18722 0.407349444564411 0.771946683725618 LIN28B/KCNQ1OT1 2 GO:0071549 cellular response to dexamethasone stimulus 2/896 29/18722 0.407349444564411 0.771946683725618 EGFR/SERPINF1 2 GO:0090025 regulation of monocyte chemotaxis 2/896 29/18722 0.407349444564411 0.771946683725618 HMGB1/ANO6 2 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 2/896 29/18722 0.407349444564411 0.771946683725618 SEMA6A/MYO1C 2 GO:1903318 negative regulation of protein maturation 2/896 29/18722 0.407349444564411 0.771946683725618 BCL2L12/GLG1 2 GO:1903513 endoplasmic reticulum to cytosol transport 2/896 29/18722 0.407349444564411 0.771946683725618 HSP90B1/UBE2G2 2 GO:0034394 protein localization to cell surface 4/896 68/18722 0.411001816194612 0.771946683725618 EMP2/VCL/GOPC/HSP90AB1 4 GO:0042267 natural killer cell mediated cytotoxicity 4/896 68/18722 0.411001816194612 0.771946683725618 TUBB/TUBB4B/CADM1/KIF5B 4 GO:1901607 alpha-amino acid biosynthetic process 4/896 68/18722 0.411001816194612 0.771946683725618 DHFR/PLOD2/MTR/MTAP 4 GO:0016482 cytosolic transport 9/896 168/18722 0.41316468367978 0.771946683725618 EMP2/SRSF10/VPS13A/SNX5/RDX/EEA1/KIF5B/RHOBTB3/CLTC 9 GO:0033138 positive regulation of peptidyl-serine phosphorylation 6/896 108/18722 0.414370342501999 0.771946683725618 EGFR/APP/HSP90AA1/AKAP9/EIF4G1/HSP90AB1 6 GO:0001765 membrane raft assembly 1/896 11/18722 0.417019375225884 0.771946683725618 EMP2 1 GO:0001967 suckling behavior 1/896 11/18722 0.417019375225884 0.771946683725618 APP 1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 1/896 11/18722 0.417019375225884 0.771946683725618 CD46 1 GO:0003157 endocardium development 1/896 11/18722 0.417019375225884 0.771946683725618 RBPJ 1 GO:0006002 fructose 6-phosphate metabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 GFPT1 1 GO:0008611 ether lipid biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 CHPT1 1 GO:0009155 purine deoxyribonucleotide catabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 NUDT15 1 GO:0009235 cobalamin metabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 MTR 1 GO:0014010 Schwann cell proliferation 1/896 11/18722 0.417019375225884 0.771946683725618 DICER1 1 GO:0014854 response to inactivity 1/896 11/18722 0.417019375225884 0.771946683725618 DAG1 1 GO:0018026 peptidyl-lysine monomethylation 1/896 11/18722 0.417019375225884 0.771946683725618 SETD2 1 GO:0018342 protein prenylation 1/896 11/18722 0.417019375225884 0.771946683725618 CHML 1 GO:0030432 peristalsis 1/896 11/18722 0.417019375225884 0.771946683725618 DLG1 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/896 11/18722 0.417019375225884 0.771946683725618 CCNB1 1 GO:0032276 regulation of gonadotropin secretion 1/896 11/18722 0.417019375225884 0.771946683725618 GJA1 1 GO:0032351 negative regulation of hormone metabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 ATP1A1 1 GO:0033625 positive regulation of integrin activation 1/896 11/18722 0.417019375225884 0.771946683725618 FERMT1 1 GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/896 11/18722 0.417019375225884 0.771946683725618 DPP4 1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1/896 11/18722 0.417019375225884 0.771946683725618 EXOSC8 1 GO:0034454 microtubule anchoring at centrosome 1/896 11/18722 0.417019375225884 0.771946683725618 PCM1 1 GO:0034770 histone H4-K20 methylation 1/896 11/18722 0.417019375225884 0.771946683725618 BRCA1 1 GO:0035457 cellular response to interferon-alpha 1/896 11/18722 0.417019375225884 0.771946683725618 TPR 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/896 11/18722 0.417019375225884 0.771946683725618 EIF4G1 1 GO:0042451 purine nucleoside biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 MTAP 1 GO:0042455 ribonucleoside biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 MTAP 1 GO:0044068 modulation by symbiont of host cellular process 1/896 11/18722 0.417019375225884 0.771946683725618 ANO6 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/896 11/18722 0.417019375225884 0.771946683725618 HMGB2 1 GO:0045793 positive regulation of cell size 1/896 11/18722 0.417019375225884 0.771946683725618 HSP90AB1 1 GO:0045945 positive regulation of transcription by RNA polymerase III 1/896 11/18722 0.417019375225884 0.771946683725618 ICE1 1 GO:0046129 purine ribonucleoside biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 MTAP 1 GO:0046349 amino sugar biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 GFPT1 1 GO:0046504 glycerol ether biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 CHPT1 1 GO:0046598 positive regulation of viral entry into host cell 1/896 11/18722 0.417019375225884 0.771946683725618 P4HB 1 GO:0046643 regulation of gamma-delta T cell activation 1/896 11/18722 0.417019375225884 0.771946683725618 SOX4 1 GO:0046710 GDP metabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 DLG1 1 GO:0046940 nucleoside monophosphate phosphorylation 1/896 11/18722 0.417019375225884 0.771946683725618 DTYMK 1 GO:0048102 autophagic cell death 1/896 11/18722 0.417019375225884 0.771946683725618 CTSV 1 GO:0048680 positive regulation of axon regeneration 1/896 11/18722 0.417019375225884 0.771946683725618 LRP1 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/896 11/18722 0.417019375225884 0.771946683725618 NF1 1 GO:0048853 forebrain morphogenesis 1/896 11/18722 0.417019375225884 0.771946683725618 NF1 1 GO:0051561 positive regulation of mitochondrial calcium ion concentration 1/896 11/18722 0.417019375225884 0.771946683725618 TGM2 1 GO:0051610 serotonin uptake 1/896 11/18722 0.417019375225884 0.771946683725618 SLC6A4 1 GO:0060174 limb bud formation 1/896 11/18722 0.417019375225884 0.771946683725618 SOX4 1 GO:0060379 cardiac muscle cell myoblast differentiation 1/896 11/18722 0.417019375225884 0.771946683725618 RBPJ 1 GO:0060746 parental behavior 1/896 11/18722 0.417019375225884 0.771946683725618 ZFX 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/896 11/18722 0.417019375225884 0.771946683725618 SERPINF1 1 GO:0061029 eyelid development in camera-type eye 1/896 11/18722 0.417019375225884 0.771946683725618 HDAC2 1 GO:0061635 regulation of protein complex stability 1/896 11/18722 0.417019375225884 0.771946683725618 HSPA8 1 GO:0070314 G1 to G0 transition 1/896 11/18722 0.417019375225884 0.771946683725618 EZH2 1 GO:0070341 fat cell proliferation 1/896 11/18722 0.417019375225884 0.771946683725618 TFDP1 1 GO:0070344 regulation of fat cell proliferation 1/896 11/18722 0.417019375225884 0.771946683725618 TFDP1 1 GO:0070778 L-aspartate transmembrane transport 1/896 11/18722 0.417019375225884 0.771946683725618 SLC1A5 1 GO:0070933 histone H4 deacetylation 1/896 11/18722 0.417019375225884 0.771946683725618 HDAC2 1 GO:0071044 histone mRNA catabolic process 1/896 11/18722 0.417019375225884 0.771946683725618 DCP2 1 GO:0071492 cellular response to UV-A 1/896 11/18722 0.417019375225884 0.771946683725618 MME 1 GO:0072017 distal tubule development 1/896 11/18722 0.417019375225884 0.771946683725618 PKD2 1 GO:0072110 glomerular mesangial cell proliferation 1/896 11/18722 0.417019375225884 0.771946683725618 BMP7 1 GO:0072173 metanephric tubule morphogenesis 1/896 11/18722 0.417019375225884 0.771946683725618 LGR4 1 GO:0072205 metanephric collecting duct development 1/896 11/18722 0.417019375225884 0.771946683725618 DLG5 1 GO:0075294 positive regulation by symbiont of entry into host 1/896 11/18722 0.417019375225884 0.771946683725618 P4HB 1 GO:0075522 IRES-dependent viral translational initiation 1/896 11/18722 0.417019375225884 0.771946683725618 EIF3A 1 GO:0086016 AV node cell action potential 1/896 11/18722 0.417019375225884 0.771946683725618 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/896 11/18722 0.417019375225884 0.771946683725618 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/896 11/18722 0.417019375225884 0.771946683725618 GJA5 1 GO:0090030 regulation of steroid hormone biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 ATP1A1 1 GO:0090657 telomeric loop disassembly 1/896 11/18722 0.417019375225884 0.771946683725618 BLM 1 GO:0097354 prenylation 1/896 11/18722 0.417019375225884 0.771946683725618 CHML 1 GO:0097384 cellular lipid biosynthetic process 1/896 11/18722 0.417019375225884 0.771946683725618 CHPT1 1 GO:0099022 vesicle tethering 1/896 11/18722 0.417019375225884 0.771946683725618 TRIP11 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/896 11/18722 0.417019375225884 0.771946683725618 ATRX 1 GO:1900222 negative regulation of amyloid-beta clearance 1/896 11/18722 0.417019375225884 0.771946683725618 LRPAP1 1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 1/896 11/18722 0.417019375225884 0.771946683725618 HSPA9 1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1/896 11/18722 0.417019375225884 0.771946683725618 CALM2 1 GO:1902188 positive regulation of viral release from host cell 1/896 11/18722 0.417019375225884 0.771946683725618 DDB1 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/896 11/18722 0.417019375225884 0.771946683725618 BMP7 1 GO:1902667 regulation of axon guidance 1/896 11/18722 0.417019375225884 0.771946683725618 NRP1 1 GO:1902915 negative regulation of protein polyubiquitination 1/896 11/18722 0.417019375225884 0.771946683725618 TRIM44 1 GO:1903299 regulation of hexokinase activity 1/896 11/18722 0.417019375225884 0.771946683725618 RANBP2 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/896 11/18722 0.417019375225884 0.771946683725618 HSPA5 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/896 11/18722 0.417019375225884 0.771946683725618 IDH2 1 GO:1905050 positive regulation of metallopeptidase activity 1/896 11/18722 0.417019375225884 0.771946683725618 CLDN4 1 GO:1905150 regulation of voltage-gated sodium channel activity 1/896 11/18722 0.417019375225884 0.771946683725618 KIF5B 1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1/896 11/18722 0.417019375225884 0.771946683725618 HSPA5 1 GO:1990773 matrix metallopeptidase secretion 1/896 11/18722 0.417019375225884 0.771946683725618 IDH2 1 GO:2000392 regulation of lamellipodium morphogenesis 1/896 11/18722 0.417019375225884 0.771946683725618 KANK1 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/896 11/18722 0.417019375225884 0.771946683725618 BMP7 1 GO:0009066 aspartate family amino acid metabolic process 3/896 49/18722 0.418185788109034 0.772010422441039 PLOD2/MTR/MTAP 3 GO:0018198 peptidyl-cysteine modification 3/896 49/18722 0.418185788109034 0.772010422441039 ZDHHC12/OXR1/ADH5 3 GO:0072666 establishment of protein localization to vacuole 3/896 49/18722 0.418185788109034 0.772010422441039 VPS13A/NEDD4/HSPA8 3 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 3/896 49/18722 0.418185788109034 0.772010422441039 GJA1/ADAMTS1/DNMT1 3 GO:1904752 regulation of vascular associated smooth muscle cell migration 3/896 49/18722 0.418185788109034 0.772010422441039 ADAMTS1/IQGAP1/LRP1 3 GO:1904894 positive regulation of receptor signaling pathway via STAT 3/896 49/18722 0.418185788109034 0.772010422441039 CENPJ/PRLR/OCIAD1 3 GO:1990573 potassium ion import across plasma membrane 3/896 49/18722 0.418185788109034 0.772010422441039 ATP1A1/DLG1/ATP1B3 3 GO:0031214 biomineral tissue development 9/896 169/18722 0.420040182465052 0.775134066906903 FBN2/ATP2B1/BMP7/SLC20A1/FBXO5/ROCK2/LGR4/ANKH/ANO6 9 GO:0050688 regulation of defense response to virus 4/896 69/18722 0.421872225572244 0.776191051621369 HSP90AA1/HERC5/DHX9/TRIM44 4 GO:0032410 negative regulation of transporter activity 6/896 109/18722 0.422969431612212 0.776191051621369 ANK3/PKD2/CALM2/NEDD4/GOPC/FMR1 6 GO:0034766 negative regulation of ion transmembrane transport 6/896 109/18722 0.422969431612212 0.776191051621369 ANK3/PKD2/CALM2/NEDD4/GOPC/FMR1 6 GO:0014910 regulation of smooth muscle cell migration 5/896 89/18722 0.423009670356394 0.776191051621369 NRP1/SEMA6D/ADAMTS1/IQGAP1/LRP1 5 GO:0003299 muscle hypertrophy in response to stress 2/896 30/18722 0.424189872995423 0.776191051621369 EZH2/ATP2A2 2 GO:0006099 tricarboxylic acid cycle 2/896 30/18722 0.424189872995423 0.776191051621369 DHTKD1/IDH2 2 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 2/896 30/18722 0.424189872995423 0.776191051621369 TOP2A/DICER1 2 GO:0010453 regulation of cell fate commitment 2/896 30/18722 0.424189872995423 0.776191051621369 ESRP1/LMO4 2 GO:0014887 cardiac muscle adaptation 2/896 30/18722 0.424189872995423 0.776191051621369 EZH2/ATP2A2 2 GO:0014898 cardiac muscle hypertrophy in response to stress 2/896 30/18722 0.424189872995423 0.776191051621369 EZH2/ATP2A2 2 GO:0017145 stem cell division 2/896 30/18722 0.424189872995423 0.776191051621369 ETV5/NCOA3 2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 2/896 30/18722 0.424189872995423 0.776191051621369 CTSV/CTSL 2 GO:0034390 smooth muscle cell apoptotic process 2/896 30/18722 0.424189872995423 0.776191051621369 CDKN2A/DNMT1 2 GO:0034391 regulation of smooth muscle cell apoptotic process 2/896 30/18722 0.424189872995423 0.776191051621369 CDKN2A/DNMT1 2 GO:0045948 positive regulation of translational initiation 2/896 30/18722 0.424189872995423 0.776191051621369 KHDRBS1/LARP1 2 GO:0048147 negative regulation of fibroblast proliferation 2/896 30/18722 0.424189872995423 0.776191051621369 PAWR/NF1 2 GO:0051491 positive regulation of filopodium assembly 2/896 30/18722 0.424189872995423 0.776191051621369 NRP1/FMR1 2 GO:0060292 long-term synaptic depression 2/896 30/18722 0.424189872995423 0.776191051621369 PPP1R9A/FMR1 2 GO:0060351 cartilage development involved in endochondral bone morphogenesis 2/896 30/18722 0.424189872995423 0.776191051621369 TRIP11/SERPINH1 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/896 30/18722 0.424189872995423 0.776191051621369 GALNT11/RBPJ 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/896 30/18722 0.424189872995423 0.776191051621369 SLC39A10/AURKB 2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 2/896 30/18722 0.424189872995423 0.776191051621369 HSPA5/UFL1 2 GO:0009566 fertilization 10/896 190/18722 0.425157267751275 0.777663140323597 CDK1/NR2F2/CD46/HEXB/ASH1L/SPESP1/CCT5/ZFX/CCT2/CCT4 10 GO:0010632 regulation of epithelial cell migration 15/896 292/18722 0.426715567900986 0.780214523615207 HMGB1/MET/NRP2/NRP1/NR2F2/MARVELD3/EMP2/NF1/ROCK2/PTPRM/MACF1/CALR/TACSTD2/SERPINF1/RTN4 15 GO:0006352 DNA-templated transcription, initiation 7/896 130/18722 0.430184545666534 0.781215574169039 HMGB1/TFAM/BDP1/SMARCA4/ZNF451/SMARCA5/BCLAF1 7 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 7/896 130/18722 0.430184545666534 0.781215574169039 LMAN1/PGAP1/GOPC/TRIP11/ERGIC2/TMED4/CNIH4 7 GO:0042476 odontogenesis 7/896 130/18722 0.430184545666534 0.781215574169039 LAMB1/PERP/BMP7/LAMA5/ANKRD11/HDAC2/BSG 7 GO:0018023 peptidyl-lysine trimethylation 3/896 50/18722 0.431064705274049 0.781215574169039 SETD2/BRD4/ATRX 3 GO:0019083 viral transcription 3/896 50/18722 0.431064705274049 0.781215574169039 NUCKS1/DHX9/SMARCA4 3 GO:0050873 brown fat cell differentiation 3/896 50/18722 0.431064705274049 0.781215574169039 BMP7/ADRB1/HNRNPU 3 GO:1904738 vascular associated smooth muscle cell migration 3/896 50/18722 0.431064705274049 0.781215574169039 ADAMTS1/IQGAP1/LRP1 3 GO:0014812 muscle cell migration 6/896 110/18722 0.431550996056795 0.781215574169039 NRP1/SEMA6D/ADAMTS1/NET1/IQGAP1/LRP1 6 GO:0048259 regulation of receptor-mediated endocytosis 6/896 110/18722 0.431550996056795 0.781215574169039 ITGAV/DGKD/AHI1/FMR1/CD2AP/LRPAP1 6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 5/896 90/18722 0.432519721708047 0.781215574169039 AURKA/CDC20/PLK1/FBXO22/RNF217 5 GO:0003407 neural retina development 4/896 70/18722 0.432693284924116 0.781215574169039 ATP2B1/PTPRM/AHI1/SMARCA4 4 GO:0110148 biomineralization 9/896 171/18722 0.433778943061412 0.781215574169039 FBN2/ATP2B1/BMP7/SLC20A1/FBXO5/ROCK2/LGR4/ANKH/ANO6 9 GO:1904064 positive regulation of cation transmembrane transport 8/896 151/18722 0.43592214483107 0.781215574169039 ANK3/PKD2/ALG10B/CALM2/AKAP9/KIF5B/ATP1B3/ANO6 8 GO:0002230 positive regulation of defense response to virus by host 2/896 31/18722 0.440777788822321 0.781215574169039 HSP90AA1/TRIM44 2 GO:0018200 peptidyl-glutamic acid modification 2/896 31/18722 0.440777788822321 0.781215574169039 PARP1/VKORC1 2 GO:0030201 heparan sulfate proteoglycan metabolic process 2/896 31/18722 0.440777788822321 0.781215574169039 HS6ST2/EXTL2 2 GO:0030212 hyaluronan metabolic process 2/896 31/18722 0.440777788822321 0.781215574169039 ITIH5/CLTC 2 GO:0036474 cell death in response to hydrogen peroxide 2/896 31/18722 0.440777788822321 0.781215574169039 MET/PAWR 2 GO:0043171 peptide catabolic process 2/896 31/18722 0.440777788822321 0.781215574169039 ENPEP/NPEPPS 2 GO:0051569 regulation of histone H3-K4 methylation 2/896 31/18722 0.440777788822321 0.781215574169039 BRCA1/DNMT1 2 GO:0055075 potassium ion homeostasis 2/896 31/18722 0.440777788822321 0.781215574169039 ATP1A1/ATP1B3 2 GO:0070528 protein kinase C signaling 2/896 31/18722 0.440777788822321 0.781215574169039 ADGRG1/DGKD 2 GO:0097106 postsynaptic density organization 2/896 31/18722 0.440777788822321 0.781215574169039 DLG1/ZDHHC12 2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/896 31/18722 0.440777788822321 0.781215574169039 HMGB2/BRCA1 2 GO:1905144 response to acetylcholine 2/896 31/18722 0.440777788822321 0.781215574169039 ROCK2/LY6E 2 GO:1905145 cellular response to acetylcholine 2/896 31/18722 0.440777788822321 0.781215574169039 ROCK2/LY6E 2 GO:0055006 cardiac cell development 5/896 91/18722 0.441996168763793 0.781215574169039 CCNB1/CDK1/PARP2/HNRNPU/TGFBR3 5 GO:0098661 inorganic anion transmembrane transport 5/896 91/18722 0.441996168763793 0.781215574169039 SLC20A1/GABRE/SLC26A2/ANKH/ANO6 5 GO:0006839 mitochondrial transport 13/896 254/18722 0.442371160711982 0.781215574169039 HSP90AA1/LMAN1/ARHGAP11B/SFXN1/FZD5/SAE1/SLC25A36/SLC25A1/NPEPPS/AFG3L2/HUWE1/HSPD1/SLC25A5 13 GO:0016125 sterol metabolic process 8/896 152/18722 0.443227012262637 0.781215574169039 APP/LBR/DHCR24/LRP5/VLDLR/FDPS/SQLE/LIMA1 8 GO:0090501 RNA phosphodiester bond hydrolysis 8/896 152/18722 0.443227012262637 0.781215574169039 FEN1/RNASEH2A/EXOSC8/AGO2/DICER1/DCP2/CNOT1/RPS21 8 GO:0002228 natural killer cell mediated immunity 4/896 71/18722 0.443458199083415 0.781215574169039 TUBB/TUBB4B/CADM1/KIF5B 4 GO:0008344 adult locomotory behavior 4/896 71/18722 0.443458199083415 0.781215574169039 APP/EPS8/OXR1/PUM1 4 GO:0021872 forebrain generation of neurons 3/896 51/18722 0.443838637514212 0.781215574169039 ASPM/NRP2/NRP1 3 GO:0045104 intermediate filament cytoskeleton organization 3/896 51/18722 0.443838637514212 0.781215574169039 DSP/DST/MACF1 3 GO:0045668 negative regulation of osteoblast differentiation 3/896 51/18722 0.443838637514212 0.781215574169039 LRP5/CRIM1/CDK6 3 GO:0046850 regulation of bone remodeling 3/896 51/18722 0.443838637514212 0.781215574169039 EGFR/NF1/SUCO 3 GO:0048013 ephrin receptor signaling pathway 3/896 51/18722 0.443838637514212 0.781215574169039 YES1/RBPJ/RASA1 3 GO:0000012 single strand break repair 1/896 12/18722 0.444936142891835 0.781215574169039 PARP1 1 GO:0002024 diet induced thermogenesis 1/896 12/18722 0.444936142891835 0.781215574169039 ADRB1 1 GO:0002674 negative regulation of acute inflammatory response 1/896 12/18722 0.444936142891835 0.781215574169039 ASH1L 1 GO:0003207 cardiac chamber formation 1/896 12/18722 0.444936142891835 0.781215574169039 SOX4 1 GO:0003306 Wnt signaling pathway involved in heart development 1/896 12/18722 0.444936142891835 0.781215574169039 RBPJ 1 GO:0006285 base-excision repair, AP site formation 1/896 12/18722 0.444936142891835 0.781215574169039 UNG 1 GO:0006534 cysteine metabolic process 1/896 12/18722 0.444936142891835 0.781215574169039 GCLM 1 GO:0007320 insemination 1/896 12/18722 0.444936142891835 0.781215574169039 SLC6A4 1 GO:0007614 short-term memory 1/896 12/18722 0.444936142891835 0.781215574169039 SERPINF1 1 GO:0010623 programmed cell death involved in cell development 1/896 12/18722 0.444936142891835 0.781215574169039 PRKDC 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/896 12/18722 0.444936142891835 0.781215574169039 LRP1 1 GO:0021527 spinal cord association neuron differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 LMO4 1 GO:0021559 trigeminal nerve development 1/896 12/18722 0.444936142891835 0.781215574169039 NRP1 1 GO:0021670 lateral ventricle development 1/896 12/18722 0.444936142891835 0.781215574169039 CDK6 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/896 12/18722 0.444936142891835 0.781215574169039 SLC6A4 1 GO:0030238 male sex determination 1/896 12/18722 0.444936142891835 0.781215574169039 SF1 1 GO:0031223 auditory behavior 1/896 12/18722 0.444936142891835 0.781215574169039 CNTNAP2 1 GO:0032621 interleukin-18 production 1/896 12/18722 0.444936142891835 0.781215574169039 DHX9 1 GO:0032661 regulation of interleukin-18 production 1/896 12/18722 0.444936142891835 0.781215574169039 DHX9 1 GO:0032908 regulation of transforming growth factor beta1 production 1/896 12/18722 0.444936142891835 0.781215574169039 CD2AP 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/896 12/18722 0.444936142891835 0.781215574169039 HMGB1 1 GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/896 12/18722 0.444936142891835 0.781215574169039 DNMT1 1 GO:0035092 sperm chromatin condensation 1/896 12/18722 0.444936142891835 0.781215574169039 SRPK1 1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 1/896 12/18722 0.444936142891835 0.781215574169039 COL4A2 1 GO:0042118 endothelial cell activation 1/896 12/18722 0.444936142891835 0.781215574169039 APOLD1 1 GO:0043248 proteasome assembly 1/896 12/18722 0.444936142891835 0.781215574169039 PSMD11 1 GO:0043380 regulation of memory T cell differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 CD46 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/896 12/18722 0.444936142891835 0.781215574169039 HMGB1 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/896 12/18722 0.444936142891835 0.781215574169039 PHIP 1 GO:0044650 adhesion of symbiont to host cell 1/896 12/18722 0.444936142891835 0.781215574169039 HSP90AB1 1 GO:0045602 negative regulation of endothelial cell differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 ID1 1 GO:0045605 negative regulation of epidermal cell differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 EZH2 1 GO:0045683 negative regulation of epidermis development 1/896 12/18722 0.444936142891835 0.781215574169039 EZH2 1 GO:0045916 negative regulation of complement activation 1/896 12/18722 0.444936142891835 0.781215574169039 CD46 1 GO:0046185 aldehyde catabolic process 1/896 12/18722 0.444936142891835 0.781215574169039 ADH5 1 GO:0048742 regulation of skeletal muscle fiber development 1/896 12/18722 0.444936142891835 0.781215574169039 FBXO22 1 GO:0051013 microtubule severing 1/896 12/18722 0.444936142891835 0.781215574169039 FIGNL1 1 GO:0051340 regulation of ligase activity 1/896 12/18722 0.444936142891835 0.781215574169039 GCLM 1 GO:0060009 Sertoli cell development 1/896 12/18722 0.444936142891835 0.781215574169039 ATRX 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/896 12/18722 0.444936142891835 0.781215574169039 LRP1 1 GO:0060442 branching involved in prostate gland morphogenesis 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:0060601 lateral sprouting from an epithelium 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:0060788 ectodermal placode formation 1/896 12/18722 0.444936142891835 0.781215574169039 HDAC2 1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/896 12/18722 0.444936142891835 0.781215574169039 PARP2 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:0070572 positive regulation of neuron projection regeneration 1/896 12/18722 0.444936142891835 0.781215574169039 LRP1 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/896 12/18722 0.444936142891835 0.781215574169039 BRD4 1 GO:0071107 response to parathyroid hormone 1/896 12/18722 0.444936142891835 0.781215574169039 GJA1 1 GO:0071697 ectodermal placode morphogenesis 1/896 12/18722 0.444936142891835 0.781215574169039 HDAC2 1 GO:0072376 protein activation cascade 1/896 12/18722 0.444936142891835 0.781215574169039 FBLN1 1 GO:0072537 fibroblast activation 1/896 12/18722 0.444936142891835 0.781215574169039 GCLM 1 GO:0086067 AV node cell to bundle of His cell communication 1/896 12/18722 0.444936142891835 0.781215574169039 GJA5 1 GO:0090677 reversible differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 DNMT1 1 GO:0097152 mesenchymal cell apoptotic process 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/896 12/18722 0.444936142891835 0.781215574169039 PPP1R9A 1 GO:1901503 ether biosynthetic process 1/896 12/18722 0.444936142891835 0.781215574169039 CHPT1 1 GO:1903332 regulation of protein folding 1/896 12/18722 0.444936142891835 0.781215574169039 HSPA5 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/896 12/18722 0.444936142891835 0.781215574169039 SLC25A5 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/896 12/18722 0.444936142891835 0.781215574169039 EGFR 1 GO:1904748 regulation of apoptotic process involved in development 1/896 12/18722 0.444936142891835 0.781215574169039 BMP7 1 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1/896 12/18722 0.444936142891835 0.781215574169039 RYK 1 GO:1905205 positive regulation of connective tissue replacement 1/896 12/18722 0.444936142891835 0.781215574169039 ROCK2 1 GO:1905245 regulation of aspartic-type peptidase activity 1/896 12/18722 0.444936142891835 0.781215574169039 ROCK2 1 GO:1905709 negative regulation of membrane permeability 1/896 12/18722 0.444936142891835 0.781215574169039 ARHGAP11B 1 GO:2000009 negative regulation of protein localization to cell surface 1/896 12/18722 0.444936142891835 0.781215574169039 GOPC 1 GO:2000035 regulation of stem cell division 1/896 12/18722 0.444936142891835 0.781215574169039 NCOA3 1 GO:2000303 regulation of ceramide biosynthetic process 1/896 12/18722 0.444936142891835 0.781215574169039 ORMDL1 1 GO:2000508 regulation of dendritic cell chemotaxis 1/896 12/18722 0.444936142891835 0.781215574169039 CALR 1 GO:2001204 regulation of osteoclast development 1/896 12/18722 0.444936142891835 0.781215574169039 FBN1 1 GO:0035264 multicellular organism growth 7/896 132/18722 0.445899707601738 0.782619560327462 APP/XRCC2/ADRB1/AFG3L2/PLEKHA1/ATRX/ZFX 7 GO:0006694 steroid biosynthetic process 9/896 173/18722 0.447488039887021 0.78483023601052 SLC27A2/LBR/DHCR24/ATP1A1/PBX1/SF1/PRLR/FDPS/SQLE 9 GO:0010469 regulation of signaling receptor activity 9/896 173/18722 0.447488039887021 0.78483023601052 APP/ITGB1/NRP1/NCAPG2/AKAP9/LY6E/HDAC2/LRPAP1/NCOA3 9 GO:0009141 nucleoside triphosphate metabolic process 6/896 112/18722 0.448646732482718 0.786284691950256 TYMS/DUT/PARP1/DTYMK/NUDT15/RAN 6 GO:0010633 negative regulation of epithelial cell migration 6/896 112/18722 0.448646732482718 0.786284691950256 HMGB1/NR2F2/MARVELD3/PTPRM/TACSTD2/SERPINF1 6 GO:0007338 single fertilization 8/896 153/18722 0.450518353216936 0.789275089268864 CDK1/CD46/HEXB/ASH1L/SPESP1/CCT5/CCT2/CCT4 8 GO:0001708 cell fate specification 5/896 92/18722 0.451434280833823 0.790589602604794 ITGB1/NRP1/ESRP1/RBPJ/LMO4 5 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 7/896 133/18722 0.453729510943654 0.791163647078361 AURKA/CDC20/PLK1/TMTC3/FBXO22/RNF217/FMR1 7 GO:0035567 non-canonical Wnt signaling pathway 4/896 72/18722 0.454160481132165 0.791163647078361 ZNRF3/FZD5/FZD6/RYK 4 GO:0051057 positive regulation of small GTPase mediated signal transduction 4/896 72/18722 0.454160481132165 0.791163647078361 ADGRG1/ITGAV/NET1/TGM2 4 GO:0001659 temperature homeostasis 9/896 174/18722 0.454326571538419 0.791163647078361 GJA1/IGF1R/ADRB1/LGR4/PRLR/DYNC1H1/ID1/RBPJ/RHEB 9 GO:0043392 negative regulation of DNA binding 3/896 52/18722 0.456498063881686 0.791163647078361 NEK2/ID1/HDAC2 3 GO:0045103 intermediate filament-based process 3/896 52/18722 0.456498063881686 0.791163647078361 DSP/DST/MACF1 3 GO:0048260 positive regulation of receptor-mediated endocytosis 3/896 52/18722 0.456498063881686 0.791163647078361 DGKD/AHI1/FMR1 3 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 3/896 52/18722 0.456498063881686 0.791163647078361 ZNRF3/FZD6/RYK 3 GO:0072523 purine-containing compound catabolic process 3/896 52/18722 0.456498063881686 0.791163647078361 NUDT15/HINT1/NUDT4 3 GO:0006026 aminoglycan catabolic process 2/896 32/18722 0.457098779811051 0.791163647078361 GUSB/GLB1 2 GO:0006506 GPI anchor biosynthetic process 2/896 32/18722 0.457098779811051 0.791163647078361 PGAP1/GPAA1 2 GO:0009954 proximal/distal pattern formation 2/896 32/18722 0.457098779811051 0.791163647078361 PBX1/IRX2 2 GO:0010039 response to iron ion 2/896 32/18722 0.457098779811051 0.791163647078361 CCNB1/CCND1 2 GO:0019228 neuronal action potential 2/896 32/18722 0.457098779811051 0.791163647078361 ANK3/FMR1 2 GO:0030431 sleep 2/896 32/18722 0.457098779811051 0.791163647078361 SLC29A1/ADRB1 2 GO:0035883 enteroendocrine cell differentiation 2/896 32/18722 0.457098779811051 0.791163647078361 CDK6/RHEB 2 GO:0045761 regulation of adenylate cyclase activity 2/896 32/18722 0.457098779811051 0.791163647078361 NF1/AKAP9 2 GO:0060914 heart formation 2/896 32/18722 0.457098779811051 0.791163647078361 LRP2/RBPJ 2 GO:1901185 negative regulation of ERBB signaling pathway 2/896 32/18722 0.457098779811051 0.791163647078361 EGFR/SNX5 2 GO:1901532 regulation of hematopoietic progenitor cell differentiation 2/896 32/18722 0.457098779811051 0.791163647078361 PRKDC/HSPA9 2 GO:1901889 negative regulation of cell junction assembly 2/896 32/18722 0.457098779811051 0.791163647078361 ROCK2/LRP1 2 GO:0030073 insulin secretion 10/896 195/18722 0.457545460649267 0.791163647078361 DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/FAM3B 10 GO:0005996 monosaccharide metabolic process 13/896 257/18722 0.459277583689448 0.791163647078361 HMGB1/SLC35B4/LRP5/FUT8/SOGA1/PGP/UXS1/SLC25A1/RANBP2/SLC2A1/GLB1/FUCA2/DDB1 13 GO:0007589 body fluid secretion 5/896 93/18722 0.460829492394443 0.791163647078361 EGFR/SLC29A1/CCND1/PPAT/PRLR 5 GO:0051591 response to cAMP 5/896 93/18722 0.460829492394443 0.791163647078361 APP/PKD2/HSPA5/AKAP9/BSG 5 GO:0022900 electron transport chain 9/896 175/18722 0.461151879077891 0.791163647078361 CCNB1/CDK1/ASPH/GLDC/DEGS1/CYB5B/AKR7A2/CYB5A/ADH5 9 GO:0048771 tissue remodeling 9/896 175/18722 0.461151879077891 0.791163647078361 EGFR/GJA1/LRP5/NF1/ROCK2/LGR4/SUCO/RBPJ/TGM2 9 GO:0050954 sensory perception of mechanical stimulus 9/896 175/18722 0.461151879077891 0.791163647078361 LRP2/BIRC5/PGAP1/MARVELD2/TBL1X/USP53/HEXB/ALDH7A1/TRIOBP 9 GO:0007281 germ cell development 14/896 278/18722 0.46142084223634 0.791163647078361 HMGB2/ASPM/CCNB1/BRCA2/AURKA/LGR5/SMARCA2/FBXO5/MSH2/SRPK1/CEP57/HEXB/ETV5/ZFX 14 GO:0061041 regulation of wound healing 7/896 134/18722 0.461537083217667 0.791163647078361 HMGB1/ITGB1/GJA1/KANK1/FERMT1/ANO6/CLDN4 7 GO:0032732 positive regulation of interleukin-1 production 4/896 73/18722 0.464793951212408 0.791163647078361 HMGB1/APP/FZD5/HDAC2 4 GO:0035924 cellular response to vascular endothelial growth factor stimulus 4/896 73/18722 0.464793951212408 0.791163647078361 NRP2/NRP1/SEMA6A/MYO1C 4 GO:0042274 ribosomal small subunit biogenesis 4/896 73/18722 0.464793951212408 0.791163647078361 PRKDC/XRCC5/RPS21/RPS17 4 GO:0042593 glucose homeostasis 13/896 258/18722 0.464901190689406 0.791163647078361 NUCKS1/SLC29A1/IGF1R/LRP5/SOX4/SLC16A1/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1/FAM3B 13 GO:0006665 sphingolipid metabolic process 8/896 155/18722 0.465051340069522 0.791163647078361 HACD3/ITGB8/DEGS1/HEXB/KDSR/GLB1/ORMDL1/TECR 8 GO:0031279 regulation of cyclase activity 3/896 53/18722 0.469034137124104 0.791163647078361 CALM2/NF1/AKAP9 3 GO:0034381 plasma lipoprotein particle clearance 3/896 53/18722 0.469034137124104 0.791163647078361 VLDLR/KHSRP/LRPAP1 3 GO:1903202 negative regulation of oxidative stress-induced cell death 3/896 53/18722 0.469034137124104 0.791163647078361 MET/OXR1/NONO 3 GO:0042157 lipoprotein metabolic process 7/896 135/18722 0.469319722598929 0.791163647078361 ITGAV/PGAP1/APOLD1/GPAA1/ZDHHC12/LRP1/DBI 7 GO:0032091 negative regulation of protein binding 5/896 94/18722 0.470177404359413 0.791163647078361 AURKA/AURKB/ATP2A2/ID1/LRPAP1 5 GO:0033500 carbohydrate homeostasis 13/896 259/18722 0.470517064546311 0.791163647078361 NUCKS1/SLC29A1/IGF1R/LRP5/SOX4/SLC16A1/GCLM/SMARCA4/KIF5B/LRP1/TRA2B/SERPINF1/FAM3B 13 GO:0001778 plasma membrane repair 1/896 13/18722 0.471517501308132 0.791163647078361 MYOF 1 GO:0001886 endothelial cell morphogenesis 1/896 13/18722 0.471517501308132 0.791163647078361 MET 1 GO:0002638 negative regulation of immunoglobulin production 1/896 13/18722 0.471517501308132 0.791163647078361 PRKDC 1 GO:0003222 ventricular trabecula myocardium morphogenesis 1/896 13/18722 0.471517501308132 0.791163647078361 RBPJ 1 GO:0005513 detection of calcium ion 1/896 13/18722 0.471517501308132 0.791163647078361 CALM2 1 GO:0006361 transcription initiation from RNA polymerase I promoter 1/896 13/18722 0.471517501308132 0.791163647078361 SMARCA4 1 GO:0007183 SMAD protein complex assembly 1/896 13/18722 0.471517501308132 0.791163647078361 PARP1 1 GO:0007494 midgut development 1/896 13/18722 0.471517501308132 0.791163647078361 EGFR 1 GO:0010635 regulation of mitochondrial fusion 1/896 13/18722 0.471517501308132 0.791163647078361 HUWE1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 ITGAV 1 GO:0014029 neural crest formation 1/896 13/18722 0.471517501308132 0.791163647078361 TCOF1 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/896 13/18722 0.471517501308132 0.791163647078361 PAXBP1 1 GO:0015791 polyol transport 1/896 13/18722 0.471517501308132 0.791163647078361 SLC5A3 1 GO:0016024 CDP-diacylglycerol biosynthetic process 1/896 13/18722 0.471517501308132 0.791163647078361 CDS1 1 GO:0016322 neuron remodeling 1/896 13/18722 0.471517501308132 0.791163647078361 APP 1 GO:0021514 ventral spinal cord interneuron differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 LMO4 1 GO:0021681 cerebellar granular layer development 1/896 13/18722 0.471517501308132 0.791163647078361 KIF14 1 GO:0021794 thalamus development 1/896 13/18722 0.471517501308132 0.791163647078361 CNTNAP2 1 GO:0021819 layer formation in cerebral cortex 1/896 13/18722 0.471517501308132 0.791163647078361 ADGRG1 1 GO:0032042 mitochondrial DNA metabolic process 1/896 13/18722 0.471517501308132 0.791163647078361 PARP1 1 GO:0032252 secretory granule localization 1/896 13/18722 0.471517501308132 0.791163647078361 KIF5B 1 GO:0032530 regulation of microvillus organization 1/896 13/18722 0.471517501308132 0.791163647078361 KLF5 1 GO:0032905 transforming growth factor beta1 production 1/896 13/18722 0.471517501308132 0.791163647078361 CD2AP 1 GO:0033689 negative regulation of osteoblast proliferation 1/896 13/18722 0.471517501308132 0.791163647078361 PLXNB1 1 GO:0034112 positive regulation of homotypic cell-cell adhesion 1/896 13/18722 0.471517501308132 0.791163647078361 ANK3 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/896 13/18722 0.471517501308132 0.791163647078361 HMGB1 1 GO:0034982 mitochondrial protein processing 1/896 13/18722 0.471517501308132 0.791163647078361 AFG3L2 1 GO:0035845 photoreceptor cell outer segment organization 1/896 13/18722 0.471517501308132 0.791163647078361 AHI1 1 GO:0036302 atrioventricular canal development 1/896 13/18722 0.471517501308132 0.791163647078361 RBPJ 1 GO:0042308 negative regulation of protein import into nucleus 1/896 13/18722 0.471517501308132 0.791163647078361 FERMT1 1 GO:0042492 gamma-delta T cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 SOX4 1 GO:0043247 telomere maintenance in response to DNA damage 1/896 13/18722 0.471517501308132 0.791163647078361 RIF1 1 GO:0043379 memory T cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 CD46 1 GO:0046689 response to mercury ion 1/896 13/18722 0.471517501308132 0.791163647078361 BSG 1 GO:0048266 behavioral response to pain 1/896 13/18722 0.471517501308132 0.791163647078361 VWA1 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/896 13/18722 0.471517501308132 0.791163647078361 MSH2 1 GO:0051451 myoblast migration 1/896 13/18722 0.471517501308132 0.791163647078361 NET1 1 GO:0060100 positive regulation of phagocytosis, engulfment 1/896 13/18722 0.471517501308132 0.791163647078361 ANO6 1 GO:0060707 trophoblast giant cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 NR2F2 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/896 13/18722 0.471517501308132 0.791163647078361 RBPJ 1 GO:0061744 motor behavior 1/896 13/18722 0.471517501308132 0.791163647078361 DPP4 1 GO:0070254 mucus secretion 1/896 13/18722 0.471517501308132 0.791163647078361 EGFR 1 GO:0070316 regulation of G0 to G1 transition 1/896 13/18722 0.471517501308132 0.791163647078361 CHEK1 1 GO:0070486 leukocyte aggregation 1/896 13/18722 0.471517501308132 0.791163647078361 BMP7 1 GO:0071027 nuclear RNA surveillance 1/896 13/18722 0.471517501308132 0.791163647078361 EXOSC8 1 GO:0071028 nuclear mRNA surveillance 1/896 13/18722 0.471517501308132 0.791163647078361 EXOSC8 1 GO:0071801 regulation of podosome assembly 1/896 13/18722 0.471517501308132 0.791163647078361 ASAP1 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/896 13/18722 0.471517501308132 0.791163647078361 PCM1 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/896 13/18722 0.471517501308132 0.791163647078361 ORMDL1 1 GO:0090161 Golgi ribbon formation 1/896 13/18722 0.471517501308132 0.791163647078361 TRIP11 1 GO:0098840 protein transport along microtubule 1/896 13/18722 0.471517501308132 0.791163647078361 KIF5B 1 GO:0099118 microtubule-based protein transport 1/896 13/18722 0.471517501308132 0.791163647078361 KIF5B 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/896 13/18722 0.471517501308132 0.791163647078361 IARS2 1 GO:0110096 cellular response to aldehyde 1/896 13/18722 0.471517501308132 0.791163647078361 ADH5 1 GO:1900121 negative regulation of receptor binding 1/896 13/18722 0.471517501308132 0.791163647078361 ATP2A2 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/896 13/18722 0.471517501308132 0.791163647078361 ANK3 1 GO:1903054 negative regulation of extracellular matrix organization 1/896 13/18722 0.471517501308132 0.791163647078361 DPP4 1 GO:1903651 positive regulation of cytoplasmic transport 1/896 13/18722 0.471517501308132 0.791163647078361 RDX 1 GO:1903977 positive regulation of glial cell migration 1/896 13/18722 0.471517501308132 0.791163647078361 LRP1 1 GO:1904590 negative regulation of protein import 1/896 13/18722 0.471517501308132 0.791163647078361 FERMT1 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/896 13/18722 0.471517501308132 0.791163647078361 HUWE1 1 GO:1905038 regulation of membrane lipid metabolic process 1/896 13/18722 0.471517501308132 0.791163647078361 ORMDL1 1 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 DNMT1 1 GO:1905155 positive regulation of membrane invagination 1/896 13/18722 0.471517501308132 0.791163647078361 ANO6 1 GO:1905203 regulation of connective tissue replacement 1/896 13/18722 0.471517501308132 0.791163647078361 ROCK2 1 GO:1990403 embryonic brain development 1/896 13/18722 0.471517501308132 0.791163647078361 TRA2B 1 GO:2001023 regulation of response to drug 1/896 13/18722 0.471517501308132 0.791163647078361 ADIRF 1 GO:2001198 regulation of dendritic cell differentiation 1/896 13/18722 0.471517501308132 0.791163647078361 HMGB1 1 GO:0001975 response to amphetamine 2/896 33/18722 0.47314038802026 0.791163647078361 RANBP2/HDAC2 2 GO:0006505 GPI anchor metabolic process 2/896 33/18722 0.47314038802026 0.791163647078361 PGAP1/GPAA1 2 GO:0010984 regulation of lipoprotein particle clearance 2/896 33/18722 0.47314038802026 0.791163647078361 KHSRP/LRPAP1 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/896 33/18722 0.47314038802026 0.791163647078361 ZDHHC12/KIF5B 2 GO:0033198 response to ATP 2/896 33/18722 0.47314038802026 0.791163647078361 HSP90B1/HSPD1 2 GO:0034110 regulation of homotypic cell-cell adhesion 2/896 33/18722 0.47314038802026 0.791163647078361 ANK3/RDX 2 GO:0035025 positive regulation of Rho protein signal transduction 2/896 33/18722 0.47314038802026 0.791163647078361 ADGRG1/NET1 2 GO:0045648 positive regulation of erythrocyte differentiation 2/896 33/18722 0.47314038802026 0.791163647078361 HMGB2/PRKDC 2 GO:0046685 response to arsenic-containing substance 2/896 33/18722 0.47314038802026 0.791163647078361 SLC38A2/SERPINF1 2 GO:0060122 inner ear receptor cell stereocilium organization 2/896 33/18722 0.47314038802026 0.791163647078361 TRIP11/TRIOBP 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/896 33/18722 0.47314038802026 0.791163647078361 HMGB1/ZNF451 2 GO:0070570 regulation of neuron projection regeneration 2/896 33/18722 0.47314038802026 0.791163647078361 STK24/LRP1 2 GO:0071295 cellular response to vitamin 2/896 33/18722 0.47314038802026 0.791163647078361 ATP2B1/TRIM24 2 GO:0099084 postsynaptic specialization organization 2/896 33/18722 0.47314038802026 0.791163647078361 DLG1/ZDHHC12 2 GO:0099174 regulation of presynapse organization 2/896 33/18722 0.47314038802026 0.791163647078361 APP/EIF4G1 2 GO:0150117 positive regulation of cell-substrate junction organization 2/896 33/18722 0.47314038802026 0.791163647078361 NRP1/IQGAP1 2 GO:1900181 negative regulation of protein localization to nucleus 2/896 33/18722 0.47314038802026 0.791163647078361 FERMT1/MAGED1 2 GO:1902692 regulation of neuroblast proliferation 2/896 33/18722 0.47314038802026 0.791163647078361 ASPM/NF1 2 GO:1903146 regulation of autophagy of mitochondrion 2/896 33/18722 0.47314038802026 0.791163647078361 FZD5/SLC25A5 2 GO:1905606 regulation of presynapse assembly 2/896 33/18722 0.47314038802026 0.791163647078361 APP/EIF4G1 2 GO:0043405 regulation of MAP kinase activity 9/896 177/18722 0.474755382812038 0.793586203622083 EGFR/EZH2/BMP7/FZD5/NF1/IQGAP1/MAGED1/CD24/ERP29 9 GO:0002437 inflammatory response to antigenic stimulus 4/896 74/18722 0.475352734570909 0.794028675591854 HMGB2/HMGB1/YES1/RBPJ 4 GO:0006635 fatty acid beta-oxidation 4/896 74/18722 0.475352734570909 0.794028675591854 SLC27A2/ACAT2/ECHDC2/HADHA 4 GO:0098876 vesicle-mediated transport to the plasma membrane 7/896 136/18722 0.477074795010918 0.796626467779686 SPTBN1/CLSTN1/ANK3/GOLGA4/MACF1/GOPC/CMTM6 7 GO:0007249 I-kappaB kinase/NF-kappaB signaling 14/896 281/18722 0.47762927267732 0.797273478238296 ECT2/HACD3/WLS/SLC20A1/GJA1/SLC44A2/ROCK2/USP10/PRDX4/ASH1L/BRD4/UFL1/TMED4/TGM2 14 GO:0034764 positive regulation of transmembrane transport 11/896 219/18722 0.478679389569583 0.798747083469132 TCAF1/ITGB1/ANK3/PKD2/ALG10B/CALM2/ARL6IP1/AKAP9/KIF5B/ATP1B3/ANO6 11 GO:0045666 positive regulation of neuron differentiation 5/896 95/18722 0.479473784936519 0.799513744075076 ECT2/BMP7/NRCAM/EIF4G1/ETV5 5 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5/896 95/18722 0.479473784936519 0.799513744075076 MAD2L1/FBXO5/SOX4/UFL1/TRIM44 5 GO:0014888 striated muscle adaptation 3/896 54/18722 0.481438663881508 0.802381836865482 EZH2/ATP2A2/CAMK2G 3 GO:0035265 organ growth 9/896 178/18722 0.481529946087056 0.802381836865482 CCNB1/CDK1/GJA1/PARP2/SLC6A4/YAP1/TGFBR3/LY6E/RBPJ 9 GO:0015849 organic acid transport 15/896 303/18722 0.484193577437461 0.806538778327438 LRP2/SLC27A2/ITGB1/SLC38A1/GJA1/SFXN1/SLC16A1/SLC26A2/ARL6IP1/SLC38A2/SLC1A5/SLC25A1/SLC7A6/SLC2A1/SLC13A3 15 GO:0090090 negative regulation of canonical Wnt signaling pathway 7/896 137/18722 0.484799735305348 0.80726680723674 TPBG/ZNRF3/FZD6/FERMT1/G3BP1/CTNND1/TLE4 7 GO:1903363 negative regulation of cellular protein catabolic process 4/896 75/18722 0.485831258900974 0.807302025299589 PBK/SMARCC1/USP14/HSP90AB1 4 GO:0006813 potassium ion transport 12/896 241/18722 0.486110010069251 0.807302025299589 ITGB1/GJA5/ATP1A1/ANK3/PKD2/ALG10B/DLG1/NEDD4/AKAP9/KIF5B/ATP1B3/ANO6 12 GO:0044262 cellular carbohydrate metabolic process 14/896 283/18722 0.488392210845549 0.807302025299589 HMGB1/AGL/SLC35B4/SOGA1/ENOSF1/SLC5A3/PGP/GUSB/RANBP2/PHKB/GLB1/IDH2/DDB1/ISYNA1 14 GO:0051146 striated muscle cell differentiation 14/896 283/18722 0.488392210845549 0.807302025299589 CCNB1/CDK1/EZH2/ITGB1/PARP2/MYEF2/KLF5/HNRNPU/FBXO22/CALR/CSRP2/RBPJ/CACYBP/MYOF 14 GO:1901655 cellular response to ketone 5/896 96/18722 0.488714570091224 0.807302025299589 EGFR/ATP2B1/ROCK2/LARP1/SERPINF1 5 GO:0002183 cytoplasmic translational initiation 2/896 34/18722 0.488891956116358 0.807302025299589 EIF3A/EIF4G1 2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 2/896 34/18722 0.488891956116358 0.807302025299589 CTSV/CTSL 2 GO:0019076 viral release from host cell 2/896 34/18722 0.488891956116358 0.807302025299589 TRIM28/DDB1 2 GO:0035308 negative regulation of protein dephosphorylation 2/896 34/18722 0.488891956116358 0.807302025299589 MASTL/ROCK2 2 GO:0035890 exit from host 2/896 34/18722 0.488891956116358 0.807302025299589 TRIM28/DDB1 2 GO:0035891 exit from host cell 2/896 34/18722 0.488891956116358 0.807302025299589 TRIM28/DDB1 2 GO:0043276 anoikis 2/896 34/18722 0.488891956116358 0.807302025299589 ITGB1/TFDP1 2 GO:0048261 negative regulation of receptor-mediated endocytosis 2/896 34/18722 0.488891956116358 0.807302025299589 ITGAV/LRPAP1 2 GO:0048536 spleen development 2/896 34/18722 0.488891956116358 0.807302025299589 PRKDC/PBX1 2 GO:0090075 relaxation of muscle 2/896 34/18722 0.488891956116358 0.807302025299589 ATP1A1/ATP2A2 2 GO:1990000 amyloid fibril formation 2/896 34/18722 0.488891956116358 0.807302025299589 APP/USP9X 2 GO:0003179 heart valve morphogenesis 3/896 55/18722 0.493704084148289 0.807302025299589 GJA5/SOX4/ROCK2 3 GO:0051898 negative regulation of protein kinase B signaling 3/896 55/18722 0.493704084148289 0.807302025299589 DAG1/DLG1/PLEKHA1 3 GO:0006520 cellular amino acid metabolic process 14/896 284/18722 0.493758100837281 0.807302025299589 DHFR/GLDC/ARHGAP11B/GMPS/PLOD2/ENOSF1/MTR/GCLM/PPAT/IARS2/BCAT1/MTAP/GFPT1/RIMKLB 14 GO:0001937 negative regulation of endothelial cell proliferation 4/896 76/18722 0.496224251042265 0.807302025299589 NR2F2/GJA1/NF1/PTPRM 4 GO:0001771 immunological synapse formation 1/896 14/18722 0.49682726232304 0.807302025299589 DLG1 1 GO:0002091 negative regulation of receptor internalization 1/896 14/18722 0.49682726232304 0.807302025299589 LRPAP1 1 GO:0003188 heart valve formation 1/896 14/18722 0.49682726232304 0.807302025299589 GJA5 1 GO:0003214 cardiac left ventricle morphogenesis 1/896 14/18722 0.49682726232304 0.807302025299589 RBPJ 1 GO:0006047 UDP-N-acetylglucosamine metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 GFPT1 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/896 14/18722 0.49682726232304 0.807302025299589 PRLR 1 GO:0007638 mechanosensory behavior 1/896 14/18722 0.49682726232304 0.807302025299589 CNTNAP2 1 GO:0009071 serine family amino acid catabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 GLDC 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/896 14/18722 0.49682726232304 0.807302025299589 KHSRP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/896 14/18722 0.49682726232304 0.807302025299589 DAG1 1 GO:0019321 pentose metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 UXS1 1 GO:0022038 corpus callosum development 1/896 14/18722 0.49682726232304 0.807302025299589 RYK 1 GO:0030213 hyaluronan biosynthetic process 1/896 14/18722 0.49682726232304 0.807302025299589 CLTC 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/896 14/18722 0.49682726232304 0.807302025299589 NEDD4 1 GO:0031115 negative regulation of microtubule polymerization 1/896 14/18722 0.49682726232304 0.807302025299589 STMN1 1 GO:0031468 nuclear membrane reassembly 1/896 14/18722 0.49682726232304 0.807302025299589 ANKLE2 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/896 14/18722 0.49682726232304 0.807302025299589 RDX 1 GO:0035641 locomotory exploration behavior 1/896 14/18722 0.49682726232304 0.807302025299589 DPP4 1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1/896 14/18722 0.49682726232304 0.807302025299589 LRP1 1 GO:0035815 positive regulation of renal sodium excretion 1/896 14/18722 0.49682726232304 0.807302025299589 SNX5 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/896 14/18722 0.49682726232304 0.807302025299589 DBI 1 GO:0036444 calcium import into the mitochondrion 1/896 14/18722 0.49682726232304 0.807302025299589 AFG3L2 1 GO:0042415 norepinephrine metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 LY6E 1 GO:0043922 negative regulation by host of viral transcription 1/896 14/18722 0.49682726232304 0.807302025299589 NUCKS1 1 GO:0044764 multi-organism cellular process 1/896 14/18722 0.49682726232304 0.807302025299589 CTSL 1 GO:0045023 G0 to G1 transition 1/896 14/18722 0.49682726232304 0.807302025299589 CHEK1 1 GO:0045989 positive regulation of striated muscle contraction 1/896 14/18722 0.49682726232304 0.807302025299589 ATP1A1 1 GO:0046341 CDP-diacylglycerol metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 CDS1 1 GO:0046479 glycosphingolipid catabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 HEXB 1 GO:0046655 folic acid metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 DHFR 1 GO:0048368 lateral mesoderm development 1/896 14/18722 0.49682726232304 0.807302025299589 YAP1 1 GO:0051645 Golgi localization 1/896 14/18722 0.49682726232304 0.807302025299589 ARHGAP21 1 GO:0055057 neuroblast division 1/896 14/18722 0.49682726232304 0.807302025299589 ASPM 1 GO:0060081 membrane hyperpolarization 1/896 14/18722 0.49682726232304 0.807302025299589 ATP1A1 1 GO:0060088 auditory receptor cell stereocilium organization 1/896 14/18722 0.49682726232304 0.807302025299589 TRIOBP 1 GO:0060911 cardiac cell fate commitment 1/896 14/18722 0.49682726232304 0.807302025299589 RBPJ 1 GO:0061709 reticulophagy 1/896 14/18722 0.49682726232304 0.807302025299589 UFL1 1 GO:0072350 tricarboxylic acid metabolic process 1/896 14/18722 0.49682726232304 0.807302025299589 IDH2 1 GO:0072498 embryonic skeletal joint development 1/896 14/18722 0.49682726232304 0.807302025299589 BMP7 1 GO:0090239 regulation of histone H4 acetylation 1/896 14/18722 0.49682726232304 0.807302025299589 BRCA1 1 GO:0090715 immunological memory formation process 1/896 14/18722 0.49682726232304 0.807302025299589 CD46 1 GO:0099188 postsynaptic cytoskeleton organization 1/896 14/18722 0.49682726232304 0.807302025299589 PPP1R9A 1 GO:1900037 regulation of cellular response to hypoxia 1/896 14/18722 0.49682726232304 0.807302025299589 ROCK2 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/896 14/18722 0.49682726232304 0.807302025299589 BMP7 1 GO:1902187 negative regulation of viral release from host cell 1/896 14/18722 0.49682726232304 0.807302025299589 TRIM28 1 GO:1902916 positive regulation of protein polyubiquitination 1/896 14/18722 0.49682726232304 0.807302025299589 SKP2 1 GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/896 14/18722 0.49682726232304 0.807302025299589 UBE2G2 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/896 14/18722 0.49682726232304 0.807302025299589 HUWE1 1 GO:1905049 negative regulation of metallopeptidase activity 1/896 14/18722 0.49682726232304 0.807302025299589 LRP1 1 GO:1905208 negative regulation of cardiocyte differentiation 1/896 14/18722 0.49682726232304 0.807302025299589 EGFR 1 GO:2001140 positive regulation of phospholipid transport 1/896 14/18722 0.49682726232304 0.807302025299589 DBI 1 GO:0006721 terpenoid metabolic process 5/896 97/18722 0.497895863638926 0.808213142812728 LRP2/EGFR/FDPS/LRP1/ADH5 5 GO:0014909 smooth muscle cell migration 5/896 97/18722 0.497895863638926 0.808213142812728 NRP1/SEMA6D/ADAMTS1/IQGAP1/LRP1 5 GO:0120162 positive regulation of cold-induced thermogenesis 5/896 97/18722 0.497895863638926 0.808213142812728 GJA1/IGF1R/ADRB1/PRLR/DYNC1H1 5 GO:0002831 regulation of response to biotic stimulus 16/896 327/18722 0.500308021225597 0.811576790122664 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/HERC5/SFPQ/DHX9/PSPC1/HSPD1/PUM1/NONO/TRIM44/XRCC5/XRCC6/HSP90AB1 16 GO:0007517 muscle organ development 16/896 327/18722 0.500308021225597 0.811576790122664 CENPF/LRP2/DSP/DAG1/LAMA5/NR2F2/SVIL/UTRN/ZFHX3/KLF5/FBXO22/PAXBP1/TGFBR3/LY6E/RBPJ/DDX17 16 GO:0050920 regulation of chemotaxis 11/896 223/18722 0.50295904319951 0.815600024536162 HMGB1/MET/DPP4/NRP1/SEMA6D/TPBG/SEMA6A/RYK/CALR/ANO6/USP14 11 GO:0031667 response to nutrient levels 23/896 474/18722 0.503554746115629 0.815630273075845 TYMS/EGFR/ATP2B1/AGL/BMP7/CTSV/HAT1/ADRB1/CCND1/SLC6A4/SRSF2/SLC16A1/GCLM/DNMT3A/SLC38A2/TRIM24/TNRC6A/HSPA5/LARP1/STK24/EIF4G1/SLC2A1/HSPA8 23 GO:0006471 protein ADP-ribosylation 2/896 35/18722 0.504344483896082 0.815630273075845 PARP1/PARP2 2 GO:0018149 peptide cross-linking 2/896 35/18722 0.504344483896082 0.815630273075845 DSP/TGM2 2 GO:0031076 embryonic camera-type eye development 2/896 35/18722 0.504344483896082 0.815630273075845 BMP7/FZD5 2 GO:0034405 response to fluid shear stress 2/896 35/18722 0.504344483896082 0.815630273075845 GJA1/PKD2 2 GO:0070536 protein K63-linked deubiquitination 2/896 35/18722 0.504344483896082 0.815630273075845 USP27X/PSMD14 2 GO:0071108 protein K48-linked deubiquitination 2/896 35/18722 0.504344483896082 0.815630273075845 USP27X/USP9X 2 GO:0097502 mannosylation 2/896 35/18722 0.504344483896082 0.815630273075845 TMTC3/DPY19L1 2 GO:0002090 regulation of receptor internalization 3/896 56/18722 0.505823450167223 0.815811199695379 AHI1/FMR1/LRPAP1 3 GO:0006687 glycosphingolipid metabolic process 3/896 56/18722 0.505823450167223 0.815811199695379 ITGB8/HEXB/GLB1 3 GO:0015800 acidic amino acid transport 3/896 56/18722 0.505823450167223 0.815811199695379 ITGB1/GJA1/ARL6IP1 3 GO:0022029 telencephalon cell migration 3/896 56/18722 0.505823450167223 0.815811199695379 LAMB1/ADGRG1/RTN4 3 GO:0045071 negative regulation of viral genome replication 3/896 56/18722 0.505823450167223 0.815811199695379 SRPK1/ILF3/TRIM28 3 GO:0048008 platelet-derived growth factor receptor signaling pathway 3/896 56/18722 0.505823450167223 0.815811199695379 NRP1/PLEKHA1/LRP1 3 GO:0055078 sodium ion homeostasis 3/896 56/18722 0.505823450167223 0.815811199695379 ATP1A1/SNX5/ATP1B3 3 GO:0090175 regulation of establishment of planar polarity 3/896 56/18722 0.505823450167223 0.815811199695379 ZNRF3/FZD6/RYK 3 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 5/896 98/18722 0.50701393698708 0.817455094622194 HELLS/RTKN2/FIGNL1/USP47/NONO 5 GO:0010906 regulation of glucose metabolic process 6/896 119/18722 0.507413930652289 0.817547791067846 HMGB1/SLC35B4/SOGA1/PGP/RANBP2/DDB1 6 GO:0030282 bone mineralization 6/896 119/18722 0.507413930652289 0.817547791067846 FBN2/ATP2B1/BMP7/LGR4/ANKH/ANO6 6 GO:0015748 organophosphate ester transport 7/896 140/18722 0.507769166810999 0.817844130349429 SLC29A1/GJA1/SLC25A36/TMEM30B/ANO6/DBI/SLC25A5 7 GO:0006643 membrane lipid metabolic process 10/896 203/18722 0.508701156635683 0.818059749911405 HACD3/PGAP1/ITGB8/GPAA1/DEGS1/HEXB/KDSR/GLB1/ORMDL1/TECR 10 GO:0031668 cellular response to extracellular stimulus 12/896 246/18722 0.515004033837965 0.818059749911405 ATP2B1/CTSV/NUDT15/SKP2/SLC38A2/TRIM24/TNRC6A/HSPA5/STK24/EIF4G1/SLC2A1/HSPA8 12 GO:0010717 regulation of epithelial to mesenchymal transition 5/896 99/18722 0.516065228548023 0.818059749911405 DAG1/EZH2/BMP7/GCNT2/HDAC2 5 GO:0021549 cerebellum development 5/896 99/18722 0.516065228548023 0.818059749911405 EZH2/KIF14/RERE/HNRNPD/HSPA5 5 GO:0060996 dendritic spine development 5/896 99/18722 0.516065228548023 0.818059749911405 PPP1R9A/DLG5/FMR1/ASAP1/HDAC2 5 GO:0070373 negative regulation of ERK1 and ERK2 cascade 4/896 78/18722 0.516734018015618 0.818059749911405 SEMA6A/DLG1/EIF3A/FBLN1 4 GO:0002011 morphogenesis of an epithelial sheet 3/896 57/18722 0.517790404905935 0.818059749911405 DAG1/BMP7/FERMT1 3 GO:0006695 cholesterol biosynthetic process 3/896 57/18722 0.517790404905935 0.818059749911405 LBR/DHCR24/FDPS 3 GO:0060042 retina morphogenesis in camera-type eye 3/896 57/18722 0.517790404905935 0.818059749911405 LRP5/PTPRM/AHI1 3 GO:1902653 secondary alcohol biosynthetic process 3/896 57/18722 0.517790404905935 0.818059749911405 LBR/DHCR24/FDPS 3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2/896 36/18722 0.519490494393253 0.818059749911405 CTSV/CTSL 2 GO:0003203 endocardial cushion morphogenesis 2/896 36/18722 0.519490494393253 0.818059749911405 BMP7/RBPJ 2 GO:0003230 cardiac atrium development 2/896 36/18722 0.519490494393253 0.818059749911405 GJA5/SOX4 2 GO:0010092 specification of animal organ identity 2/896 36/18722 0.519490494393253 0.818059749911405 LRP2/RBPJ 2 GO:0010923 negative regulation of phosphatase activity 2/896 36/18722 0.519490494393253 0.818059749911405 MASTL/ROCK2 2 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 2/896 36/18722 0.519490494393253 0.818059749911405 KIF5B/LRP1 2 GO:0045191 regulation of isotype switching 2/896 36/18722 0.519490494393253 0.818059749911405 RIF1/MSH2 2 GO:0051955 regulation of amino acid transport 2/896 36/18722 0.519490494393253 0.818059749911405 ITGB1/ARL6IP1 2 GO:0086010 membrane depolarization during action potential 2/896 36/18722 0.519490494393253 0.818059749911405 ANK3/YWHAH 2 GO:1901658 glycosyl compound catabolic process 2/896 36/18722 0.519490494393253 0.818059749911405 GUSB/FUCA2 2 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/896 15/18722 0.520926191816227 0.818059749911405 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/896 15/18722 0.520926191816227 0.818059749911405 RPS21 1 GO:0002836 positive regulation of response to tumor cell 1/896 15/18722 0.520926191816227 0.818059749911405 HSPD1 1 GO:0002839 positive regulation of immune response to tumor cell 1/896 15/18722 0.520926191816227 0.818059749911405 HSPD1 1 GO:0006704 glucocorticoid biosynthetic process 1/896 15/18722 0.520926191816227 0.818059749911405 ATP1A1 1 GO:0007000 nucleolus organization 1/896 15/18722 0.520926191816227 0.818059749911405 SMARCA5 1 GO:0010273 detoxification of copper ion 1/896 15/18722 0.520926191816227 0.818059749911405 MT2A 1 GO:0010763 positive regulation of fibroblast migration 1/896 15/18722 0.520926191816227 0.818059749911405 ITGB1 1 GO:0014841 skeletal muscle satellite cell proliferation 1/896 15/18722 0.520926191816227 0.818059749911405 PAXBP1 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/896 15/18722 0.520926191816227 0.818059749911405 PAXBP1 1 GO:0015697 quaternary ammonium group transport 1/896 15/18722 0.520926191816227 0.818059749911405 SLC38A2 1 GO:0016114 terpenoid biosynthetic process 1/896 15/18722 0.520926191816227 0.818059749911405 FDPS 1 GO:0018410 C-terminal protein amino acid modification 1/896 15/18722 0.520926191816227 0.818059749911405 ICMT 1 GO:0021542 dentate gyrus development 1/896 15/18722 0.520926191816227 0.818059749911405 CDK6 1 GO:0023035 CD40 signaling pathway 1/896 15/18722 0.520926191816227 0.818059749911405 ITGB1 1 GO:0032328 alanine transport 1/896 15/18722 0.520926191816227 0.818059749911405 SLC38A2 1 GO:0032488 Cdc42 protein signal transduction 1/896 15/18722 0.520926191816227 0.818059749911405 NRP1 1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 1/896 15/18722 0.520926191816227 0.818059749911405 ASXL1 1 GO:0036124 histone H3-K9 trimethylation 1/896 15/18722 0.520926191816227 0.818059749911405 ATRX 1 GO:0042559 pteridine-containing compound biosynthetic process 1/896 15/18722 0.520926191816227 0.818059749911405 DHFR 1 GO:0042754 negative regulation of circadian rhythm 1/896 15/18722 0.520926191816227 0.818059749911405 SFPQ 1 GO:0042976 activation of Janus kinase activity 1/896 15/18722 0.520926191816227 0.818059749911405 PRLR 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/896 15/18722 0.520926191816227 0.818059749911405 PKD2 1 GO:0044406 adhesion of symbiont to host 1/896 15/18722 0.520926191816227 0.818059749911405 HSP90AB1 1 GO:0044793 negative regulation by host of viral process 1/896 15/18722 0.520926191816227 0.818059749911405 NUCKS1 1 GO:0045346 regulation of MHC class II biosynthetic process 1/896 15/18722 0.520926191816227 0.818059749911405 HDAC2 1 GO:0045475 locomotor rhythm 1/896 15/18722 0.520926191816227 0.818059749911405 ZFHX3 1 GO:0045836 positive regulation of meiotic nuclear division 1/896 15/18722 0.520926191816227 0.818059749911405 RAD51AP1 1 GO:0046459 short-chain fatty acid metabolic process 1/896 15/18722 0.520926191816227 0.818059749911405 ACSS1 1 GO:0046500 S-adenosylmethionine metabolic process 1/896 15/18722 0.520926191816227 0.818059749911405 AHCYL1 1 GO:0046834 lipid phosphorylation 1/896 15/18722 0.520926191816227 0.818059749911405 DGKD 1 GO:0051775 response to redox state 1/896 15/18722 0.520926191816227 0.818059749911405 ADH5 1 GO:0060026 convergent extension 1/896 15/18722 0.520926191816227 0.818059749911405 TRIM28 1 GO:0060049 regulation of protein glycosylation 1/896 15/18722 0.520926191816227 0.818059749911405 ALG10B 1 GO:0060099 regulation of phagocytosis, engulfment 1/896 15/18722 0.520926191816227 0.818059749911405 ANO6 1 GO:0060413 atrial septum morphogenesis 1/896 15/18722 0.520926191816227 0.818059749911405 SOX4 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/896 15/18722 0.520926191816227 0.818059749911405 PGAP1 1 GO:0060766 negative regulation of androgen receptor signaling pathway 1/896 15/18722 0.520926191816227 0.818059749911405 SMARCA4 1 GO:0070207 protein homotrimerization 1/896 15/18722 0.520926191816227 0.818059749911405 SLC1A5 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/896 15/18722 0.520926191816227 0.818059749911405 TMEM30B 1 GO:0071025 RNA surveillance 1/896 15/18722 0.520926191816227 0.818059749911405 EXOSC8 1 GO:0071599 otic vesicle development 1/896 15/18722 0.520926191816227 0.818059749911405 AHI1 1 GO:0072044 collecting duct development 1/896 15/18722 0.520926191816227 0.818059749911405 DLG5 1 GO:0072224 metanephric glomerulus development 1/896 15/18722 0.520926191816227 0.818059749911405 LGR4 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/896 15/18722 0.520926191816227 0.818059749911405 CDH1 1 GO:0140374 antiviral innate immune response 1/896 15/18722 0.520926191816227 0.818059749911405 AKAP1 1 GO:0150011 regulation of neuron projection arborization 1/896 15/18722 0.520926191816227 0.818059749911405 MACF1 1 GO:1903729 regulation of plasma membrane organization 1/896 15/18722 0.520926191816227 0.818059749911405 ASAP1 1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 1/896 15/18722 0.520926191816227 0.818059749911405 LIN28B 1 GO:1905288 vascular associated smooth muscle cell apoptotic process 1/896 15/18722 0.520926191816227 0.818059749911405 DNMT1 1 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 1/896 15/18722 0.520926191816227 0.818059749911405 DNMT1 1 GO:1990169 stress response to copper ion 1/896 15/18722 0.520926191816227 0.818059749911405 MT2A 1 GO:1990822 basic amino acid transmembrane transport 1/896 15/18722 0.520926191816227 0.818059749911405 SLC7A6 1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1/896 15/18722 0.520926191816227 0.818059749911405 NEDD4 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/896 15/18722 0.520926191816227 0.818059749911405 MET 1 GO:2001138 regulation of phospholipid transport 1/896 15/18722 0.520926191816227 0.818059749911405 DBI 1 GO:0042177 negative regulation of protein catabolic process 6/896 121/18722 0.52379642458935 0.822026341548178 EGFR/MAD2L1/PBK/SMARCC1/USP14/HSP90AB1 6 GO:0048706 embryonic skeletal system development 6/896 121/18722 0.52379642458935 0.822026341548178 BMP7/DLG1/PBX1/KIAA1217/SETD2/SLC39A1 6 GO:0006066 alcohol metabolic process 17/896 353/18722 0.524946732161282 0.823176105330817 APP/DHFR/LBR/DHCR24/LRP5/SLC5A3/VLDLR/PGP/FDPS/SQLE/LIMA1/ACSS1/AKR7A2/IDH2/NUDT4/ADH5/ISYNA1 17 GO:0006664 glycolipid metabolic process 5/896 100/18722 0.52504634284297 0.823176105330817 PGAP1/ITGB8/GPAA1/HEXB/GLB1 5 GO:0045807 positive regulation of endocytosis 5/896 100/18722 0.52504634284297 0.823176105330817 DGKD/AHI1/FMR1/ANO6/LRP1 5 GO:0006029 proteoglycan metabolic process 4/896 79/18722 0.52684170471141 0.825719730233838 HS6ST2/EXTL2/CHST14/CHPF 4 GO:0050806 positive regulation of synaptic transmission 8/896 164/18722 0.529209218621602 0.828409695621634 EGFR/APP/MME/CLSTN1/PPP1R9A/ZDHHC12/KIF5B/FMR1 8 GO:0018108 peptidyl-tyrosine phosphorylation 18/896 375/18722 0.529428518728041 0.828409695621634 EFEMP1/MET/EGFR/APP/PBK/SUZ12/BAZ1B/WEE1/NRP1/TTK/IGF1R/MELK/NCAPG2/PRLR/IQGAP1/YES1/HDAC2/CD24 18 GO:0002931 response to ischemia 3/896 58/18722 0.529599160250781 0.828409695621634 GJA1/ROCK2/HSPD1 3 GO:0007405 neuroblast proliferation 3/896 58/18722 0.529599160250781 0.828409695621634 ASPM/RACGAP1/NF1 3 GO:0010043 response to zinc ion 3/896 58/18722 0.529599160250781 0.828409695621634 GGH/PARP1/MT2A 3 GO:0010559 regulation of glycoprotein biosynthetic process 3/896 58/18722 0.529599160250781 0.828409695621634 PAWR/ALG10B/AGO2 3 GO:1903509 liposaccharide metabolic process 5/896 101/18722 0.533954049317151 0.830793009278628 PGAP1/ITGB8/GPAA1/HEXB/GLB1 5 GO:0001990 regulation of systemic arterial blood pressure by hormone 2/896 37/18722 0.534323908982578 0.830793009278628 MME/ENPEP 2 GO:0003176 aortic valve development 2/896 37/18722 0.534323908982578 0.830793009278628 ROCK2/RBPJ 2 GO:0034260 negative regulation of GTPase activity 2/896 37/18722 0.534323908982578 0.830793009278628 AMOT/RDX 2 GO:0045616 regulation of keratinocyte differentiation 2/896 37/18722 0.534323908982578 0.830793009278628 ROCK2/NCOA3 2 GO:0051954 positive regulation of amine transport 2/896 37/18722 0.534323908982578 0.830793009278628 ITGB1/ARL6IP1 2 GO:0060306 regulation of membrane repolarization 2/896 37/18722 0.534323908982578 0.830793009278628 GJA5/AKAP9 2 GO:0072529 pyrimidine-containing compound catabolic process 2/896 37/18722 0.534323908982578 0.830793009278628 DUT/UNG 2 GO:0050796 regulation of insulin secretion 8/896 165/18722 0.536173336472071 0.830793009278628 DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/KIF5B/LRP1 8 GO:0021766 hippocampus development 4/896 80/18722 0.536845672742605 0.830793009278628 EZH2/KIF14/CDK6/KIF5B 4 GO:0014065 phosphatidylinositol 3-kinase signaling 7/896 144/18722 0.537830039298137 0.830793009278628 EGFR/CEP55/IGF1R/NF1/NEDD4/PLXNB1/PLEKHA1 7 GO:0031644 regulation of nervous system process 7/896 144/18722 0.537830039298137 0.830793009278628 APP/DAG1/PARD3/ROCK2/DICER1/AKAP9/FMR1 7 GO:0006767 water-soluble vitamin metabolic process 3/896 59/18722 0.541244475038923 0.830793009278628 DHFR/MTR/SLC2A1 3 GO:0021885 forebrain cell migration 3/896 59/18722 0.541244475038923 0.830793009278628 LAMB1/ADGRG1/RTN4 3 GO:0051055 negative regulation of lipid biosynthetic process 3/896 59/18722 0.541244475038923 0.830793009278628 BRCA1/ATP1A1/ORMDL1 3 GO:0051568 histone H3-K4 methylation 3/896 59/18722 0.541244475038923 0.830793009278628 BRCA1/DNMT1/ASH1L 3 GO:1904063 negative regulation of cation transmembrane transport 5/896 102/18722 0.542785280885605 0.830793009278628 ANK3/PKD2/CALM2/NEDD4/FMR1 5 GO:0030307 positive regulation of cell growth 8/896 166/18722 0.543097976025841 0.830793009278628 EGFR/NRP1/PARP2/GOLGA4/MACF1/EIF4G1/LRP1/USP47 8 GO:0018212 peptidyl-tyrosine modification 18/896 378/18722 0.543305664207691 0.830793009278628 EFEMP1/MET/EGFR/APP/PBK/SUZ12/BAZ1B/WEE1/NRP1/TTK/IGF1R/MELK/NCAPG2/PRLR/IQGAP1/YES1/HDAC2/CD24 18 GO:0001732 formation of cytoplasmic translation initiation complex 1/896 16/18722 0.54387215493873 0.830793009278628 EIF3A 1 GO:0002093 auditory receptor cell morphogenesis 1/896 16/18722 0.54387215493873 0.830793009278628 TRIOBP 1 GO:0002713 negative regulation of B cell mediated immunity 1/896 16/18722 0.54387215493873 0.830793009278628 CD46 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/896 16/18722 0.54387215493873 0.830793009278628 CD46 1 GO:0002921 negative regulation of humoral immune response 1/896 16/18722 0.54387215493873 0.830793009278628 CD46 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/896 16/18722 0.54387215493873 0.830793009278628 NR2F2 1 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 1/896 16/18722 0.54387215493873 0.830793009278628 RBPJ 1 GO:0006750 glutathione biosynthetic process 1/896 16/18722 0.54387215493873 0.830793009278628 GCLM 1 GO:0006828 manganese ion transport 1/896 16/18722 0.54387215493873 0.830793009278628 TMEM165 1 GO:0007635 chemosensory behavior 1/896 16/18722 0.54387215493873 0.830793009278628 TPBG 1 GO:0009415 response to water 1/896 16/18722 0.54387215493873 0.830793009278628 PKD2 1 GO:0019377 glycolipid catabolic process 1/896 16/18722 0.54387215493873 0.830793009278628 HEXB 1 GO:0030033 microvillus assembly 1/896 16/18722 0.54387215493873 0.830793009278628 KLF5 1 GO:0030540 female genitalia development 1/896 16/18722 0.54387215493873 0.830793009278628 LRP2 1 GO:0032274 gonadotropin secretion 1/896 16/18722 0.54387215493873 0.830793009278628 GJA1 1 GO:0034138 toll-like receptor 3 signaling pathway 1/896 16/18722 0.54387215493873 0.830793009278628 COLEC12 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/896 16/18722 0.54387215493873 0.830793009278628 CDKN2A 1 GO:0035751 regulation of lysosomal lumen pH 1/896 16/18722 0.54387215493873 0.830793009278628 TMEM165 1 GO:0035970 peptidyl-threonine dephosphorylation 1/896 16/18722 0.54387215493873 0.830793009278628 PPM1G 1 GO:0042407 cristae formation 1/896 16/18722 0.54387215493873 0.830793009278628 AFG3L2 1 GO:0042795 snRNA transcription by RNA polymerase II 1/896 16/18722 0.54387215493873 0.830793009278628 ICE1 1 GO:0044849 estrous cycle 1/896 16/18722 0.54387215493873 0.830793009278628 PCNA 1 GO:0045342 MHC class II biosynthetic process 1/896 16/18722 0.54387215493873 0.830793009278628 HDAC2 1 GO:0045722 positive regulation of gluconeogenesis 1/896 16/18722 0.54387215493873 0.830793009278628 DDB1 1 GO:0045838 positive regulation of membrane potential 1/896 16/18722 0.54387215493873 0.830793009278628 ANK3 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/896 16/18722 0.54387215493873 0.830793009278628 TRIM28 1 GO:0050884 neuromuscular process controlling posture 1/896 16/18722 0.54387215493873 0.830793009278628 TMEM150C 1 GO:0051014 actin filament severing 1/896 16/18722 0.54387215493873 0.830793009278628 SVIL 1 GO:0051969 regulation of transmission of nerve impulse 1/896 16/18722 0.54387215493873 0.830793009278628 FMR1 1 GO:0060004 reflex 1/896 16/18722 0.54387215493873 0.830793009278628 AFG3L2 1 GO:0060330 regulation of response to interferon-gamma 1/896 16/18722 0.54387215493873 0.830793009278628 HSP90AB1 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/896 16/18722 0.54387215493873 0.830793009278628 HSP90AB1 1 GO:0060572 morphogenesis of an epithelial bud 1/896 16/18722 0.54387215493873 0.830793009278628 BMP7 1 GO:0071361 cellular response to ethanol 1/896 16/18722 0.54387215493873 0.830793009278628 DNMT3A 1 GO:0071391 cellular response to estrogen stimulus 1/896 16/18722 0.54387215493873 0.830793009278628 TRIM24 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/896 16/18722 0.54387215493873 0.830793009278628 HMGB1 1 GO:0072109 glomerular mesangium development 1/896 16/18722 0.54387215493873 0.830793009278628 BMP7 1 GO:0080009 mRNA methylation 1/896 16/18722 0.54387215493873 0.830793009278628 ZC3H13 1 GO:0097284 hepatocyte apoptotic process 1/896 16/18722 0.54387215493873 0.830793009278628 DNMT3A 1 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 1/896 16/18722 0.54387215493873 0.830793009278628 CLSTN1 1 GO:0099010 modification of postsynaptic structure 1/896 16/18722 0.54387215493873 0.830793009278628 MYH10 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/896 16/18722 0.54387215493873 0.830793009278628 ATP2B1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/896 16/18722 0.54387215493873 0.830793009278628 SEMA6A 1 GO:1901201 regulation of extracellular matrix assembly 1/896 16/18722 0.54387215493873 0.830793009278628 DAG1 1 GO:1902306 negative regulation of sodium ion transmembrane transport 1/896 16/18722 0.54387215493873 0.830793009278628 NEDD4 1 GO:1902570 protein localization to nucleolus 1/896 16/18722 0.54387215493873 0.830793009278628 RAN 1 GO:1904862 inhibitory synapse assembly 1/896 16/18722 0.54387215493873 0.830793009278628 PLXNB1 1 GO:1904948 midbrain dopaminergic neuron differentiation 1/896 16/18722 0.54387215493873 0.830793009278628 RYK 1 GO:1905153 regulation of membrane invagination 1/896 16/18722 0.54387215493873 0.830793009278628 ANO6 1 GO:1905906 regulation of amyloid fibril formation 1/896 16/18722 0.54387215493873 0.830793009278628 APP 1 GO:2000001 regulation of DNA damage checkpoint 1/896 16/18722 0.54387215493873 0.830793009278628 WDR76 1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1/896 16/18722 0.54387215493873 0.830793009278628 ZNRF3 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/896 16/18722 0.54387215493873 0.830793009278628 EMP2 1 GO:2001212 regulation of vasculogenesis 1/896 16/18722 0.54387215493873 0.830793009278628 EMP2 1 GO:1904062 regulation of cation transmembrane transport 17/896 357/18722 0.544000617303098 0.830793009278628 APP/ITGB1/TSPAN13/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/NEDD4/AKAP9/KIF5B/FMR1/ATP1B3/ANO6/AHNAK 17 GO:2000243 positive regulation of reproductive process 4/896 81/18722 0.546742076620664 0.834712719471394 AURKA/RAD51AP1/AGO2/HDAC2 4 GO:0097237 cellular response to toxic substance 6/896 124/18722 0.547947451949554 0.835777298324683 BMP7/DHFR/GPX8/PPP1R9A/PRDX4/ADH5 6 GO:0000578 embryonic axis specification 2/896 38/18722 0.548839930927499 0.835777298324683 FZD5/COBL 2 GO:0002478 antigen processing and presentation of exogenous peptide antigen 2/896 38/18722 0.548839930927499 0.835777298324683 CTSV/CTSL 2 GO:0006882 cellular zinc ion homeostasis 2/896 38/18722 0.548839930927499 0.835777298324683 SLC39A10/MT2A 2 GO:0007007 inner mitochondrial membrane organization 2/896 38/18722 0.548839930927499 0.835777298324683 AFG3L2/HSPA9 2 GO:0035337 fatty-acyl-CoA metabolic process 2/896 38/18722 0.548839930927499 0.835777298324683 SLC25A1/TECR 2 GO:0071398 cellular response to fatty acid 2/896 38/18722 0.548839930927499 0.835777298324683 CCNB1/XRCC5 2 GO:0098926 postsynaptic signal transduction 2/896 38/18722 0.548839930927499 0.835777298324683 KPNA2/LY6E 2 GO:0019395 fatty acid oxidation 5/896 103/18722 0.551537132228612 0.83961679504445 SLC27A2/ACAT2/ECHDC2/HADHA/ADH5 5 GO:0002712 regulation of B cell mediated immunity 3/896 60/18722 0.552721633036434 0.840615825459043 RIF1/MSH2/CD46 3 GO:0002889 regulation of immunoglobulin mediated immune response 3/896 60/18722 0.552721633036434 0.840615825459043 RIF1/MSH2/CD46 3 GO:0051965 positive regulation of synapse assembly 3/896 60/18722 0.552721633036434 0.840615825459043 TPBG/CLSTN1/DLG5 3 GO:0010594 regulation of endothelial cell migration 11/896 232/18722 0.556366028061945 0.845078229259128 HMGB1/MET/NRP2/NRP1/NR2F2/EMP2/NF1/ROCK2/PTPRM/CALR/SERPINF1 11 GO:0016575 histone deacetylation 4/896 82/18722 0.556527339782625 0.845078229259128 NCAPG2/SFPQ/TBL1X/HDAC2 4 GO:0060395 SMAD protein signal transduction 4/896 82/18722 0.556527339782625 0.845078229259128 BMP7/PARP1/SPTBN1/LRP1 4 GO:1905897 regulation of response to endoplasmic reticulum stress 4/896 82/18722 0.556527339782625 0.845078229259128 HSPA5/USP14/UFL1/ERP29 4 GO:0099173 postsynapse organization 8/896 168/18722 0.556822346362142 0.845078229259128 NRP2/NRP1/IGF1R/DLG1/ACTN1/PPP1R9A/ZDHHC12/HSPA8 8 GO:0002347 response to tumor cell 2/896 39/18722 0.563034936851351 0.845078229259128 HMGB1/HSPD1 2 GO:0021587 cerebellum morphogenesis 2/896 39/18722 0.563034936851351 0.845078229259128 KIF14/HSPA5 2 GO:0046621 negative regulation of organ growth 2/896 39/18722 0.563034936851351 0.845078229259128 GJA1/SLC6A4 2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 2/896 39/18722 0.563034936851351 0.845078229259128 PKD2/CALM2 2 GO:0009152 purine ribonucleotide biosynthetic process 8/896 169/18722 0.563618975624109 0.845078229259128 PARP1/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/TECR 8 GO:0040014 regulation of multicellular organism growth 3/896 61/18722 0.564026420958292 0.845078229259128 APP/ADRB1/AFG3L2 3 GO:1905515 non-motile cilium assembly 3/896 61/18722 0.564026420958292 0.845078229259128 CEP135/PCM1/ATMIN 3 GO:0001780 neutrophil homeostasis 1/896 17/18722 0.565720254434876 0.845078229259128 HMGB1 1 GO:0003184 pulmonary valve morphogenesis 1/896 17/18722 0.565720254434876 0.845078229259128 GJA5 1 GO:0006390 mitochondrial transcription 1/896 17/18722 0.565720254434876 0.845078229259128 TFAM 1 GO:0006474 N-terminal protein amino acid acetylation 1/896 17/18722 0.565720254434876 0.845078229259128 SOX4 1 GO:0006577 amino-acid betaine metabolic process 1/896 17/18722 0.565720254434876 0.845078229259128 ALDH7A1 1 GO:0006895 Golgi to endosome transport 1/896 17/18722 0.565720254434876 0.845078229259128 VPS13A 1 GO:0007351 tripartite regional subdivision 1/896 17/18722 0.565720254434876 0.845078229259128 FZD5 1 GO:0008595 anterior/posterior axis specification, embryo 1/896 17/18722 0.565720254434876 0.845078229259128 FZD5 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/896 17/18722 0.565720254434876 0.845078229259128 NUDT15 1 GO:0010470 regulation of gastrulation 1/896 17/18722 0.565720254434876 0.845078229259128 DAG1 1 GO:0014856 skeletal muscle cell proliferation 1/896 17/18722 0.565720254434876 0.845078229259128 PAXBP1 1 GO:0021692 cerebellar Purkinje cell layer morphogenesis 1/896 17/18722 0.565720254434876 0.845078229259128 KIF14 1 GO:0021756 striatum development 1/896 17/18722 0.565720254434876 0.845078229259128 CNTNAP2 1 GO:0032048 cardiolipin metabolic process 1/896 17/18722 0.565720254434876 0.845078229259128 HADHA 1 GO:0035269 protein O-linked mannosylation 1/896 17/18722 0.565720254434876 0.845078229259128 TMTC3 1 GO:0036035 osteoclast development 1/896 17/18722 0.565720254434876 0.845078229259128 FBN1 1 GO:0036065 fucosylation 1/896 17/18722 0.565720254434876 0.845078229259128 FUT8 1 GO:0036166 phenotypic switching 1/896 17/18722 0.565720254434876 0.845078229259128 DNMT1 1 GO:0038065 collagen-activated signaling pathway 1/896 17/18722 0.565720254434876 0.845078229259128 COL4A2 1 GO:0042339 keratan sulfate metabolic process 1/896 17/18722 0.565720254434876 0.845078229259128 GLB1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/896 17/18722 0.565720254434876 0.845078229259128 SUZ12 1 GO:0042753 positive regulation of circadian rhythm 1/896 17/18722 0.565720254434876 0.845078229259128 THRAP3 1 GO:0042953 lipoprotein transport 1/896 17/18722 0.565720254434876 0.845078229259128 LRP1 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/896 17/18722 0.565720254434876 0.845078229259128 FAT1 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/896 17/18722 0.565720254434876 0.845078229259128 CD46 1 GO:0048339 paraxial mesoderm development 1/896 17/18722 0.565720254434876 0.845078229259128 YAP1 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/896 17/18722 0.565720254434876 0.845078229259128 ATP2A2 1 GO:0051580 regulation of neurotransmitter uptake 1/896 17/18722 0.565720254434876 0.845078229259128 ITGB1 1 GO:0051797 regulation of hair follicle development 1/896 17/18722 0.565720254434876 0.845078229259128 FERMT1 1 GO:0060033 anatomical structure regression 1/896 17/18722 0.565720254434876 0.845078229259128 LRP5 1 GO:0070206 protein trimerization 1/896 17/18722 0.565720254434876 0.845078229259128 SLC1A5 1 GO:0070293 renal absorption 1/896 17/18722 0.565720254434876 0.845078229259128 CLDN4 1 GO:0070875 positive regulation of glycogen metabolic process 1/896 17/18722 0.565720254434876 0.845078229259128 HMGB1 1 GO:0071816 tail-anchored membrane protein insertion into ER membrane 1/896 17/18722 0.565720254434876 0.845078229259128 EMC1 1 GO:0072673 lamellipodium morphogenesis 1/896 17/18722 0.565720254434876 0.845078229259128 KANK1 1 GO:0090036 regulation of protein kinase C signaling 1/896 17/18722 0.565720254434876 0.845078229259128 DGKD 1 GO:0090713 immunological memory process 1/896 17/18722 0.565720254434876 0.845078229259128 CD46 1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 1/896 17/18722 0.565720254434876 0.845078229259128 AKAP9 1 GO:1902358 sulfate transmembrane transport 1/896 17/18722 0.565720254434876 0.845078229259128 SLC26A2 1 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 1/896 17/18722 0.565720254434876 0.845078229259128 NFIB 1 GO:1903540 establishment of protein localization to postsynaptic membrane 1/896 17/18722 0.565720254434876 0.845078229259128 CLSTN1 1 GO:1903818 positive regulation of voltage-gated potassium channel activity 1/896 17/18722 0.565720254434876 0.845078229259128 ALG10B 1 GO:1903830 magnesium ion transmembrane transport 1/896 17/18722 0.565720254434876 0.845078229259128 TUSC3 1 GO:2000811 negative regulation of anoikis 1/896 17/18722 0.565720254434876 0.845078229259128 ITGB1 1 GO:0007611 learning or memory 12/896 255/18722 0.565745710245532 0.845078229259128 EGFR/APP/MME/ITGB1/FEN1/TPBG/CNTNAP2/MEIS2/SLC6A4/NF1/VLDLR/SERPINF1 12 GO:0061053 somite development 4/896 83/18722 0.566198148271974 0.845489508867815 PRKDC/XRCC2/COBL/RBPJ 4 GO:0042692 muscle cell differentiation 18/896 384/18722 0.570668959283898 0.851899190625806 CCNB1/CDK1/EZH2/ITGB1/PARP2/MYEF2/ATP2A2/ACTN1/KLF5/DNMT1/HNRNPU/FBXO22/AFG3L2/CALR/CSRP2/RBPJ/CACYBP/MYOF 18 GO:0034765 regulation of ion transmembrane transport 23/896 491/18722 0.573105918026273 0.854719359700814 APP/TCAF1/ITGB1/TSPAN13/GJA5/ANK3/PKD2/ALG10B/DLG1/YWHAH/CALM2/UTRN/ARL6IP1/AHCYL1/NEDD4/AKAP9/TMEM109/GOPC/KIF5B/FMR1/ATP1B3/ANO6/AHNAK 23 GO:2000116 regulation of cysteine-type endopeptidase activity 11/896 235/18722 0.573684559529389 0.854719359700814 HMGB1/BIRC5/PERP/ASPH/DHCR24/CASP8AP2/ARL6IP1/BCL2L12/HSPD1/ANP32B/USP47 11 GO:0016525 negative regulation of angiogenesis 7/896 149/18722 0.574312582989241 0.854719359700814 AMOT/COL4A2/ADAMTS1/SEMA6A/ROCK2/PTPRM/SERPINF1 7 GO:0009311 oligosaccharide metabolic process 3/896 62/18722 0.575155106615163 0.854719359700814 FUT8/MANBA/HEXB 3 GO:0032613 interleukin-10 production 3/896 62/18722 0.575155106615163 0.854719359700814 HMGB1/CD46/HSPD1 3 GO:0032653 regulation of interleukin-10 production 3/896 62/18722 0.575155106615163 0.854719359700814 HMGB1/CD46/HSPD1 3 GO:0032731 positive regulation of interleukin-1 beta production 3/896 62/18722 0.575155106615163 0.854719359700814 HMGB1/APP/FZD5 3 GO:0046148 pigment biosynthetic process 3/896 62/18722 0.575155106615163 0.854719359700814 GMPS/PPAT/PAICS 3 GO:0046173 polyol biosynthetic process 3/896 62/18722 0.575155106615163 0.854719359700814 DHFR/PGP/ISYNA1 3 GO:0048002 antigen processing and presentation of peptide antigen 3/896 62/18722 0.575155106615163 0.854719359700814 CTSV/CALR/CTSL 3 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 3/896 62/18722 0.575155106615163 0.854719359700814 BMP7/TTK/LRP1 3 GO:0006112 energy reserve metabolic process 4/896 84/18722 0.575751444167421 0.854719359700814 HMGB1/AGL/GFPT1/PHKB 4 GO:0045445 myoblast differentiation 4/896 84/18722 0.575751444167421 0.854719359700814 DTYMK/MBNL3/RBPJ/DDX17 4 GO:0002714 positive regulation of B cell mediated immunity 2/896 40/18722 0.576906375641465 0.854719359700814 RIF1/MSH2 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/896 40/18722 0.576906375641465 0.854719359700814 RIF1/MSH2 2 GO:0032892 positive regulation of organic acid transport 2/896 40/18722 0.576906375641465 0.854719359700814 ITGB1/ARL6IP1 2 GO:0042073 intraciliary transport 2/896 40/18722 0.576906375641465 0.854719359700814 PCM1/HSPB11 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/896 40/18722 0.576906375641465 0.854719359700814 PKD2/CALM2 2 GO:0055069 zinc ion homeostasis 2/896 40/18722 0.576906375641465 0.854719359700814 SLC39A10/MT2A 2 GO:0071276 cellular response to cadmium ion 2/896 40/18722 0.576906375641465 0.854719359700814 EGFR/MT2A 2 GO:1901661 quinone metabolic process 2/896 40/18722 0.576906375641465 0.854719359700814 VKORC1/AKR7A2 2 GO:0002062 chondrocyte differentiation 5/896 106/18722 0.577289736039092 0.854719359700814 EFEMP1/NFIB/GLG1/TRIP11/SERPINH1 5 GO:0006766 vitamin metabolic process 5/896 106/18722 0.577289736039092 0.854719359700814 LRP2/DHFR/MTR/VKORC1/SLC2A1 5 GO:0030072 peptide hormone secretion 11/896 236/18722 0.579394866037617 0.854719359700814 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/FAM3B 11 GO:0001935 endothelial cell proliferation 9/896 193/18722 0.579793857003644 0.854719359700814 HMGB2/HMGB1/NRP2/NRP1/NR2F2/GJA1/DLG1/NF1/PTPRM 9 GO:0031669 cellular response to nutrient levels 10/896 215/18722 0.582461583025391 0.854719359700814 ATP2B1/CTSV/SLC38A2/TRIM24/TNRC6A/HSPA5/STK24/EIF4G1/SLC2A1/HSPA8 10 GO:0019318 hexose metabolic process 11/896 237/18722 0.585072369114548 0.854719359700814 HMGB1/SLC35B4/LRP5/FUT8/SOGA1/PGP/SLC25A1/RANBP2/GLB1/FUCA2/DDB1 11 GO:0055013 cardiac muscle cell development 4/896 85/18722 0.585184418796906 0.854719359700814 CCNB1/CDK1/PARP2/HNRNPU 4 GO:0072384 organelle transport along microtubule 4/896 85/18722 0.585184418796906 0.854719359700814 ARHGAP21/LRPPRC/DYNC1H1/KIF5B 4 GO:0031532 actin cytoskeleton reorganization 5/896 107/18722 0.585698176436424 0.854719359700814 IQGAP2/NRP1/EPS8/NRK/CD2AP 5 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 5/896 107/18722 0.585698176436424 0.854719359700814 AURKA/CDC20/PLK1/FBXO22/RNF217 5 GO:0032233 positive regulation of actin filament bundle assembly 3/896 63/18722 0.586104417261885 0.854719359700814 NRP1/ROCK2/ID1 3 GO:0000712 resolution of meiotic recombination intermediates 1/896 18/18722 0.586522962375338 0.854719359700814 TOP2A 1 GO:0001946 lymphangiogenesis 1/896 18/18722 0.586522962375338 0.854719359700814 PTPN14 1 GO:0002076 osteoblast development 1/896 18/18722 0.586522962375338 0.854719359700814 LRP5 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/896 18/18722 0.586522962375338 0.854719359700814 CALR 1 GO:0002544 chronic inflammatory response 1/896 18/18722 0.586522962375338 0.854719359700814 GJA1 1 GO:0002643 regulation of tolerance induction 1/896 18/18722 0.586522962375338 0.854719359700814 HMGB1 1 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 1/896 18/18722 0.586522962375338 0.854719359700814 CD46 1 GO:0006085 acetyl-CoA biosynthetic process 1/896 18/18722 0.586522962375338 0.854719359700814 ACSS1 1 GO:0006103 2-oxoglutarate metabolic process 1/896 18/18722 0.586522962375338 0.854719359700814 IDH2 1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process 1/896 18/18722 0.586522962375338 0.854719359700814 ALG10B 1 GO:0015693 magnesium ion transport 1/896 18/18722 0.586522962375338 0.854719359700814 TUSC3 1 GO:0019184 nonribosomal peptide biosynthetic process 1/896 18/18722 0.586522962375338 0.854719359700814 GCLM 1 GO:0030206 chondroitin sulfate biosynthetic process 1/896 18/18722 0.586522962375338 0.854719359700814 CHPF 1 GO:0030299 intestinal cholesterol absorption 1/896 18/18722 0.586522962375338 0.854719359700814 LIMA1 1 GO:0030728 ovulation 1/896 18/18722 0.586522962375338 0.854719359700814 ADAMTS1 1 GO:0030889 negative regulation of B cell proliferation 1/896 18/18722 0.586522962375338 0.854719359700814 PAWR 1 GO:0031000 response to caffeine 1/896 18/18722 0.586522962375338 0.854719359700814 HDAC2 1 GO:0031649 heat generation 1/896 18/18722 0.586522962375338 0.854719359700814 ADRB1 1 GO:0034134 toll-like receptor 2 signaling pathway 1/896 18/18722 0.586522962375338 0.854719359700814 HMGB1 1 GO:0036499 PERK-mediated unfolded protein response 1/896 18/18722 0.586522962375338 0.854719359700814 HSPA5 1 GO:0042136 neurotransmitter biosynthetic process 1/896 18/18722 0.586522962375338 0.854719359700814 SLC6A4 1 GO:0042693 muscle cell fate commitment 1/896 18/18722 0.586522962375338 0.854719359700814 RBPJ 1 GO:0044872 lipoprotein localization 1/896 18/18722 0.586522962375338 0.854719359700814 LRP1 1 GO:0045116 protein neddylation 1/896 18/18722 0.586522962375338 0.854719359700814 NAE1 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/896 18/18722 0.586522962375338 0.854719359700814 ADRB1 1 GO:0048268 clathrin coat assembly 1/896 18/18722 0.586522962375338 0.854719359700814 CLTC 1 GO:0051895 negative regulation of focal adhesion assembly 1/896 18/18722 0.586522962375338 0.854719359700814 LRP1 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/896 18/18722 0.586522962375338 0.854719359700814 PARP1 1 GO:0060602 branch elongation of an epithelium 1/896 18/18722 0.586522962375338 0.854719359700814 YAP1 1 GO:0060749 mammary gland alveolus development 1/896 18/18722 0.586522962375338 0.854719359700814 CCND1 1 GO:0060973 cell migration involved in heart development 1/896 18/18722 0.586522962375338 0.854719359700814 BMP7 1 GO:0061377 mammary gland lobule development 1/896 18/18722 0.586522962375338 0.854719359700814 CCND1 1 GO:0061687 detoxification of inorganic compound 1/896 18/18722 0.586522962375338 0.854719359700814 MT2A 1 GO:0071318 cellular response to ATP 1/896 18/18722 0.586522962375338 0.854719359700814 HSP90B1 1 GO:0071800 podosome assembly 1/896 18/18722 0.586522962375338 0.854719359700814 ASAP1 1 GO:0072079 nephron tubule formation 1/896 18/18722 0.586522962375338 0.854719359700814 IRX2 1 GO:0097107 postsynaptic density assembly 1/896 18/18722 0.586522962375338 0.854719359700814 ZDHHC12 1 GO:0097709 connective tissue replacement 1/896 18/18722 0.586522962375338 0.854719359700814 ROCK2 1 GO:0098877 neurotransmitter receptor transport to plasma membrane 1/896 18/18722 0.586522962375338 0.854719359700814 CLSTN1 1 GO:0099558 maintenance of synapse structure 1/896 18/18722 0.586522962375338 0.854719359700814 DLG1 1 GO:0150118 negative regulation of cell-substrate junction organization 1/896 18/18722 0.586522962375338 0.854719359700814 LRP1 1 GO:1902001 fatty acid transmembrane transport 1/896 18/18722 0.586522962375338 0.854719359700814 SLC2A1 1 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1/896 18/18722 0.586522962375338 0.854719359700814 SEMA6A 1 GO:1902683 regulation of receptor localization to synapse 1/896 18/18722 0.586522962375338 0.854719359700814 DAG1 1 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 1/896 18/18722 0.586522962375338 0.854719359700814 RBPJ 1 GO:2000641 regulation of early endosome to late endosome transport 1/896 18/18722 0.586522962375338 0.854719359700814 RDX 1 GO:2000181 negative regulation of blood vessel morphogenesis 7/896 151/18722 0.58851909991727 0.857366549589578 AMOT/COL4A2/ADAMTS1/SEMA6A/ROCK2/PTPRM/SERPINF1 7 GO:0010907 positive regulation of glucose metabolic process 2/896 41/18722 0.590452674324609 0.858872963810386 HMGB1/DDB1 2 GO:0032735 positive regulation of interleukin-12 production 2/896 41/18722 0.590452674324609 0.858872963810386 HMGB1/HSPD1 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/896 41/18722 0.590452674324609 0.858872963810386 CALM2/ATP2A2 2 GO:1901385 regulation of voltage-gated calcium channel activity 2/896 41/18722 0.590452674324609 0.858872963810386 FMR1/AHNAK 2 GO:2000008 regulation of protein localization to cell surface 2/896 41/18722 0.590452674324609 0.858872963810386 GOPC/HSP90AB1 2 GO:0007173 epidermal growth factor receptor signaling pathway 5/896 108/18722 0.594015061578871 0.863265724194074 EFEMP1/EGFR/DGKD/SNX5/IQGAP1 5 GO:0022037 metencephalon development 5/896 108/18722 0.594015061578871 0.863265724194074 EZH2/KIF14/RERE/HNRNPD/HSPA5 5 GO:0034440 lipid oxidation 5/896 108/18722 0.594015061578871 0.863265724194074 SLC27A2/ACAT2/ECHDC2/HADHA/ADH5 5 GO:0034103 regulation of tissue remodeling 4/896 86/18722 0.594494505771817 0.863448013455039 EGFR/NF1/ROCK2/SUCO 4 GO:0030534 adult behavior 6/896 130/18722 0.594502224597133 0.863448013455039 APP/EPS8/CNTNAP2/OXR1/PUM1/HDAC2 6 GO:1901343 negative regulation of vasculature development 7/896 152/18722 0.595533200700598 0.864682329727693 AMOT/COL4A2/ADAMTS1/SEMA6A/ROCK2/PTPRM/SERPINF1 7 GO:0006753 nucleoside phosphate metabolic process 23/896 497/18722 0.596857785803308 0.865098802320759 TYMS/RRM1/DUT/APP/DHTKD1/PARP1/TK1/DTYMK/RRM2/GMPS/DLG1/NUDT15/SLC26A2/PPAT/PAICS/UNG/HINT1/SLC25A1/RAN/ACSS1/IDH2/NUDT4/TECR 23 GO:0030858 positive regulation of epithelial cell differentiation 3/896 64/18722 0.596871518213325 0.865098802320759 AHI1/CD24/NCOA3 3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 3/896 64/18722 0.596871518213325 0.865098802320759 LRP5/KIF5B/LRP1 3 GO:0070542 response to fatty acid 3/896 64/18722 0.596871518213325 0.865098802320759 CCNB1/GLDC/XRCC5 3 GO:1903018 regulation of glycoprotein metabolic process 3/896 64/18722 0.596871518213325 0.865098802320759 PAWR/ALG10B/AGO2 3 GO:0090305 nucleic acid phosphodiester bond hydrolysis 12/896 261/18722 0.598384130401543 0.865098802320759 N4BP2/FEN1/RNASEH2A/EXOSC8/AGO2/DICER1/G3BP1/DCP2/CNOT1/RAD50/PNRC2/RPS21 12 GO:0090276 regulation of peptide hormone secretion 9/896 196/18722 0.598447450358547 0.865098802320759 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/KIF5B/LRP1 9 GO:1901342 regulation of vasculature development 16/896 348/18722 0.601929896821303 0.865098802320759 HMGB1/BRCA1/ITGB1/NRP1/AMOT/COL4A2/ITGB8/ADAMTS1/EMP2/SEMA6A/NF1/ROCK2/AGO2/PTPRM/ID1/SERPINF1 16 GO:0002456 T cell mediated immunity 5/896 109/18722 0.602238409173422 0.865098802320759 HMGB1/EMP2/FZD5/CD46/HSPD1 5 GO:0006040 amino sugar metabolic process 2/896 42/18722 0.603673150479206 0.865098802320759 EXTL2/GFPT1 2 GO:0009154 purine ribonucleotide catabolic process 2/896 42/18722 0.603673150479206 0.865098802320759 HINT1/NUDT4 2 GO:0010677 negative regulation of cellular carbohydrate metabolic process 2/896 42/18722 0.603673150479206 0.865098802320759 SOGA1/PGP 2 GO:0014912 negative regulation of smooth muscle cell migration 2/896 42/18722 0.603673150479206 0.865098802320759 SEMA6D/LRP1 2 GO:0016601 Rac protein signal transduction 2/896 42/18722 0.603673150479206 0.865098802320759 HACD3/EPS8 2 GO:0021575 hindbrain morphogenesis 2/896 42/18722 0.603673150479206 0.865098802320759 KIF14/HSPA5 2 GO:0021879 forebrain neuron differentiation 2/896 42/18722 0.603673150479206 0.865098802320759 NRP2/NRP1 2 GO:0030574 collagen catabolic process 2/896 42/18722 0.603673150479206 0.865098802320759 ITGB1/CTSL 2 GO:0032965 regulation of collagen biosynthetic process 2/896 42/18722 0.603673150479206 0.865098802320759 SUCO/HDAC2 2 GO:0045214 sarcomere organization 2/896 42/18722 0.603673150479206 0.865098802320759 ITGB1/CSRP2 2 GO:0046596 regulation of viral entry into host cell 2/896 42/18722 0.603673150479206 0.865098802320759 P4HB/LY6E 2 GO:0051602 response to electrical stimulus 2/896 42/18722 0.603673150479206 0.865098802320759 HNRNPD/AKAP9 2 GO:0016101 diterpenoid metabolic process 4/896 87/18722 0.603679373874185 0.865098802320759 LRP2/EGFR/LRP1/ADH5 4 GO:0071805 potassium ion transmembrane transport 10/896 219/18722 0.60594423641573 0.865098802320759 ITGB1/ATP1A1/ANK3/PKD2/ALG10B/DLG1/NEDD4/AKAP9/ATP1B3/ANO6 10 GO:0000729 DNA double-strand break processing 1/896 19/18722 0.606330245614843 0.865098802320759 BLM 1 GO:0002281 macrophage activation involved in immune response 1/896 19/18722 0.606330245614843 0.865098802320759 HMGB1 1 GO:0002396 MHC protein complex assembly 1/896 19/18722 0.606330245614843 0.865098802320759 CALR 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/896 19/18722 0.606330245614843 0.865098802320759 ADRB1 1 GO:0006007 glucose catabolic process 1/896 19/18722 0.606330245614843 0.865098802320759 LRP5 1 GO:0006044 N-acetylglucosamine metabolic process 1/896 19/18722 0.606330245614843 0.865098802320759 EXTL2 1 GO:0006071 glycerol metabolic process 1/896 19/18722 0.606330245614843 0.865098802320759 PGP 1 GO:0006309 apoptotic DNA fragmentation 1/896 19/18722 0.606330245614843 0.865098802320759 DICER1 1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 1/896 19/18722 0.606330245614843 0.865098802320759 ALG10B 1 GO:0007530 sex determination 1/896 19/18722 0.606330245614843 0.865098802320759 SF1 1 GO:0009081 branched-chain amino acid metabolic process 1/896 19/18722 0.606330245614843 0.865098802320759 BCAT1 1 GO:0009301 snRNA transcription 1/896 19/18722 0.606330245614843 0.865098802320759 ICE1 1 GO:0010002 cardioblast differentiation 1/896 19/18722 0.606330245614843 0.865098802320759 RBPJ 1 GO:0015802 basic amino acid transport 1/896 19/18722 0.606330245614843 0.865098802320759 SLC7A6 1 GO:0030050 vesicle transport along actin filament 1/896 19/18722 0.606330245614843 0.865098802320759 MYO1C 1 GO:0032011 ARF protein signal transduction 1/896 19/18722 0.606330245614843 0.865098802320759 ARFGEF3 1 GO:0032012 regulation of ARF protein signal transduction 1/896 19/18722 0.606330245614843 0.865098802320759 ARFGEF3 1 GO:0033194 response to hydroperoxide 1/896 19/18722 0.606330245614843 0.865098802320759 OXR1 1 GO:0035313 wound healing, spreading of epidermal cells 1/896 19/18722 0.606330245614843 0.865098802320759 FERMT1 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/896 19/18722 0.606330245614843 0.865098802320759 TECR 1 GO:0035461 vitamin transmembrane transport 1/896 19/18722 0.606330245614843 0.865098802320759 LRP2 1 GO:0044320 cellular response to leptin stimulus 1/896 19/18722 0.606330245614843 0.865098802320759 CCNA2 1 GO:0045618 positive regulation of keratinocyte differentiation 1/896 19/18722 0.606330245614843 0.865098802320759 NCOA3 1 GO:0045780 positive regulation of bone resorption 1/896 19/18722 0.606330245614843 0.865098802320759 EGFR 1 GO:0045821 positive regulation of glycolytic process 1/896 19/18722 0.606330245614843 0.865098802320759 APP 1 GO:0046782 regulation of viral transcription 1/896 19/18722 0.606330245614843 0.865098802320759 DHX9 1 GO:0051546 keratinocyte migration 1/896 19/18722 0.606330245614843 0.865098802320759 FERMT1 1 GO:0060065 uterus development 1/896 19/18722 0.606330245614843 0.865098802320759 ASH1L 1 GO:0060216 definitive hemopoiesis 1/896 19/18722 0.606330245614843 0.865098802320759 TGFBR3 1 GO:0061323 cell proliferation involved in heart morphogenesis 1/896 19/18722 0.606330245614843 0.865098802320759 RBPJ 1 GO:0098780 response to mitochondrial depolarisation 1/896 19/18722 0.606330245614843 0.865098802320759 HUWE1 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/896 19/18722 0.606330245614843 0.865098802320759 NRP1 1 GO:2000269 regulation of fibroblast apoptotic process 1/896 19/18722 0.606330245614843 0.865098802320759 XRCC2 1 GO:2000369 regulation of clathrin-dependent endocytosis 1/896 19/18722 0.606330245614843 0.865098802320759 DGKD 1 GO:2000738 positive regulation of stem cell differentiation 1/896 19/18722 0.606330245614843 0.865098802320759 TACSTD2 1 GO:0048645 animal organ formation 3/896 65/18722 0.60745399178494 0.866443189955572 LRP2/BMP7/RBPJ 3 GO:0003014 renal system process 5/896 110/18722 0.610366381226594 0.870337247304588 GJA5/GJA1/EMP2/SNX5/CLDN4 5 GO:0048562 embryonic organ morphogenesis 13/896 285/18722 0.610649322898418 0.8704807009606 FBN2/EFEMP1/FBN1/BMP7/PKD2/DLG1/FZD5/FZD6/YAP1/AHI1/SETD2/SLC39A1/TRIOBP 13 GO:0002790 peptide secretion 11/896 242/18722 0.612937955082553 0.873482327631076 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/FAM3B 11 GO:0015833 peptide transport 12/896 264/18722 0.614279890682837 0.875133452139619 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/SLC13A3/FAM3B 12 GO:0071466 cellular response to xenobiotic stimulus 8/896 177/18722 0.616235423279624 0.877323797029384 PCNA/EGFR/MCM7/NUDT15/PPAT/CYB5B/VKORC1/HSPA5 8 GO:0009268 response to pH 2/896 43/18722 0.616567930775333 0.877323797029384 GJA1/SERPINF1 2 GO:0021983 pituitary gland development 2/896 43/18722 0.616567930775333 0.877323797029384 CDH1/RBPJ 2 GO:0010595 positive regulation of endothelial cell migration 6/896 133/18722 0.616802500833117 0.877323797029384 HMGB1/MET/NRP2/NRP1/ROCK2/CALR 6 GO:0046887 positive regulation of hormone secretion 6/896 133/18722 0.616802500833117 0.877323797029384 EGFR/GJA1/SOX4/TM7SF3/KIF5B/LRP1 6 GO:0046626 regulation of insulin receptor signaling pathway 3/896 66/18722 0.617849816607658 0.877323797029384 NUCKS1/KANK1/SNX5 3 GO:0050766 positive regulation of phagocytosis 3/896 66/18722 0.617849816607658 0.877323797029384 CALR/ANO6/LRP1 3 GO:1902476 chloride transmembrane transport 3/896 66/18722 0.617849816607658 0.877323797029384 GABRE/SLC26A2/ANO6 3 GO:2000272 negative regulation of signaling receptor activity 3/896 66/18722 0.617849816607658 0.877323797029384 NCAPG2/LY6E/LRPAP1 3 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 5/896 111/18722 0.618397280951955 0.877323797029384 EGFR/CEP55/IGF1R/NEDD4/PLXNB1 5 GO:0051607 defense response to virus 12/896 265/18722 0.619510961995748 0.877323797029384 HSP90AA1/HERC5/SKP2/AKAP1/ILF3/G3BP1/DHX9/SETD2/NCBP3/PUM1/TRIM44/DDX17 12 GO:0140546 defense response to symbiont 12/896 265/18722 0.619510961995748 0.877323797029384 HSP90AA1/HERC5/SKP2/AKAP1/ILF3/G3BP1/DHX9/SETD2/NCBP3/PUM1/TRIM44/DDX17 12 GO:0016311 dephosphorylation 19/896 417/18722 0.620886489379322 0.877323797029384 CDKN3/HSP90B1/SLC39A10/CDCA2/PTPN14/ATP1A1/MASTL/DLG1/CALM2/CTDSPL2/ROCK2/PTPRM/CTDSPL/ANKLE2/PPM1G/PGP/PPP4R1/CAMK2G/HSP90AB1 19 GO:0006109 regulation of carbohydrate metabolic process 8/896 178/18722 0.622574504559274 0.877323797029384 HMGB1/APP/SLC35B4/SOGA1/PGP/RANBP2/CLTC/DDB1 8 GO:0002791 regulation of peptide secretion 9/896 200/18722 0.622678348862732 0.877323797029384 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/KIF5B/LRP1 9 GO:0072522 purine-containing compound biosynthetic process 9/896 200/18722 0.622678348862732 0.877323797029384 PARP1/GMPS/SLC26A2/PPAT/PAICS/MTAP/SLC25A1/ACSS1/TECR 9 GO:0009267 cellular response to starvation 7/896 156/18722 0.622963282391301 0.877323797029384 CTSV/SLC38A2/TNRC6A/HSPA5/STK24/SLC2A1/HSPA8 7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/896 20/18722 0.625189685273139 0.877323797029384 BRD4 1 GO:0003159 morphogenesis of an endothelium 1/896 20/18722 0.625189685273139 0.877323797029384 RBPJ 1 GO:0003215 cardiac right ventricle morphogenesis 1/896 20/18722 0.625189685273139 0.877323797029384 SOX4 1 GO:0006837 serotonin transport 1/896 20/18722 0.625189685273139 0.877323797029384 SLC6A4 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/896 20/18722 0.625189685273139 0.877323797029384 AFG3L2 1 GO:0007194 negative regulation of adenylate cyclase activity 1/896 20/18722 0.625189685273139 0.877323797029384 AKAP9 1 GO:0007620 copulation 1/896 20/18722 0.625189685273139 0.877323797029384 SLC6A4 1 GO:0014047 glutamate secretion 1/896 20/18722 0.625189685273139 0.877323797029384 GJA1 1 GO:0017121 plasma membrane phospholipid scrambling 1/896 20/18722 0.625189685273139 0.877323797029384 ANO6 1 GO:0021516 dorsal spinal cord development 1/896 20/18722 0.625189685273139 0.877323797029384 LMO4 1 GO:0032930 positive regulation of superoxide anion generation 1/896 20/18722 0.625189685273139 0.877323797029384 EGFR 1 GO:0039535 regulation of RIG-I signaling pathway 1/896 20/18722 0.625189685273139 0.877323797029384 PUM1 1 GO:0042359 vitamin D metabolic process 1/896 20/18722 0.625189685273139 0.877323797029384 LRP2 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/896 20/18722 0.625189685273139 0.877323797029384 AGO2 1 GO:0043046 DNA methylation involved in gamete generation 1/896 20/18722 0.625189685273139 0.877323797029384 DNMT3A 1 GO:0043555 regulation of translation in response to stress 1/896 20/18722 0.625189685273139 0.877323797029384 EIF4G1 1 GO:0043984 histone H4-K16 acetylation 1/896 20/18722 0.625189685273139 0.877323797029384 BRCA1 1 GO:0045063 T-helper 1 cell differentiation 1/896 20/18722 0.625189685273139 0.877323797029384 HMGB1 1 GO:0046485 ether lipid metabolic process 1/896 20/18722 0.625189685273139 0.877323797029384 CHPT1 1 GO:0046629 gamma-delta T cell activation 1/896 20/18722 0.625189685273139 0.877323797029384 SOX4 1 GO:0048670 regulation of collateral sprouting 1/896 20/18722 0.625189685273139 0.877323797029384 LRP1 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/896 20/18722 0.625189685273139 0.877323797029384 GJA1 1 GO:0061154 endothelial tube morphogenesis 1/896 20/18722 0.625189685273139 0.877323797029384 RBPJ 1 GO:0071243 cellular response to arsenic-containing substance 1/896 20/18722 0.625189685273139 0.877323797029384 SLC38A2 1 GO:0071397 cellular response to cholesterol 1/896 20/18722 0.625189685273139 0.877323797029384 DAG1 1 GO:0071625 vocalization behavior 1/896 20/18722 0.625189685273139 0.877323797029384 CNTNAP2 1 GO:0097320 plasma membrane tubulation 1/896 20/18722 0.625189685273139 0.877323797029384 ASAP1 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/896 20/18722 0.625189685273139 0.877323797029384 FMR1 1 GO:1902004 positive regulation of amyloid-beta formation 1/896 20/18722 0.625189685273139 0.877323797029384 ROCK2 1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/896 20/18722 0.625189685273139 0.877323797029384 NONO 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/896 20/18722 0.625189685273139 0.877323797029384 MET 1 GO:1903817 negative regulation of voltage-gated potassium channel activity 1/896 20/18722 0.625189685273139 0.877323797029384 ANK3 1 GO:1904292 regulation of ERAD pathway 1/896 20/18722 0.625189685273139 0.877323797029384 USP14 1 GO:2000010 positive regulation of protein localization to cell surface 1/896 20/18722 0.625189685273139 0.877323797029384 HSP90AB1 1 GO:0042130 negative regulation of T cell proliferation 3/896 67/18722 0.628057347359756 0.879503430887243 PAWR/DLG1/DLG5 3 GO:0048814 regulation of dendrite morphogenesis 3/896 67/18722 0.628057347359756 0.879503430887243 YWHAH/NEDD4/ID1 3 GO:0050435 amyloid-beta metabolic process 3/896 67/18722 0.628057347359756 0.879503430887243 MME/ROCK2/RTN4 3 GO:1903317 regulation of protein maturation 3/896 67/18722 0.628057347359756 0.879503430887243 SOX4/BCL2L12/GLG1 3 GO:0001936 regulation of endothelial cell proliferation 8/896 179/18722 0.628857100274439 0.879503430887243 HMGB2/HMGB1/NRP2/NRP1/NR2F2/GJA1/NF1/PTPRM 8 GO:0010950 positive regulation of endopeptidase activity 8/896 179/18722 0.628857100274439 0.879503430887243 HMGB1/PERP/ASPH/CASP8AP2/ROCK2/HSPD1/ANP32B/PSMD14 8 GO:0006378 mRNA polyadenylation 2/896 44/18722 0.629137875257632 0.879503430887243 APP/AHCYL1 2 GO:0006775 fat-soluble vitamin metabolic process 2/896 44/18722 0.629137875257632 0.879503430887243 LRP2/VKORC1 2 GO:0030521 androgen receptor signaling pathway 2/896 44/18722 0.629137875257632 0.879503430887243 SMARCA4/DDX17 2 GO:0032881 regulation of polysaccharide metabolic process 2/896 44/18722 0.629137875257632 0.879503430887243 HMGB1/CLTC 2 GO:0045124 regulation of bone resorption 2/896 44/18722 0.629137875257632 0.879503430887243 EGFR/NF1 2 GO:0046006 regulation of activated T cell proliferation 2/896 44/18722 0.629137875257632 0.879503430887243 HMGB1/CD24 2 GO:0050999 regulation of nitric-oxide synthase activity 2/896 44/18722 0.629137875257632 0.879503430887243 EGFR/DHFR 2 GO:2000377 regulation of reactive oxygen species metabolic process 7/896 157/18722 0.629658079898356 0.879972972316965 EGFR/BMP7/BRCA1/DHFR/FOXM1/SLC5A3/HSPD1 7 GO:0045638 negative regulation of myeloid cell differentiation 4/896 90/18722 0.63046272792181 0.880839643868517 FBN1/MEIS2/CDK6/HSPA9 4 GO:0001578 microtubule bundle formation 5/896 113/18722 0.634161763027555 0.883054881553051 PRC1/PLK1/CDK5RAP2/KIF20A/CLIP1 5 GO:0002708 positive regulation of lymphocyte mediated immunity 5/896 113/18722 0.634161763027555 0.883054881553051 CADM1/RIF1/MSH2/FZD5/HSPD1 5 GO:0090087 regulation of peptide transport 9/896 202/18722 0.634502275442588 0.883054881553051 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/KIF5B/LRP1 9 GO:0051348 negative regulation of transferase activity 12/896 268/18722 0.634992606620884 0.883054881553051 MAD2L1/BMP7/IPO7/NR2F2/FBXO5/PLK1/LRP5/IPO5/NCAPG2/NF1/CDKN2A/HNRNPU 12 GO:0072503 cellular divalent inorganic cation homeostasis 22/896 486/18722 0.637539290906216 0.883054881553051 HMGB1/HSP90B1/ATP2B1/APP/ITGAV/SLC39A10/MCOLN3/GJA1/PKD2/ATP13A3/MT2A/CALM2/ATP2A2/CCDC47/TRPM7/AFG3L2/CALR/HEXB/LRP1/CD24/TMEM165/TGM2 22 GO:0007585 respiratory gaseous exchange by respiratory system 3/896 68/18722 0.638075294951993 0.883054881553051 FUT8/SLC5A3/ADH5 3 GO:0042987 amyloid precursor protein catabolic process 3/896 68/18722 0.638075294951993 0.883054881553051 DHCR24/ROCK2/RTN4 3 GO:0051926 negative regulation of calcium ion transport 3/896 68/18722 0.638075294951993 0.883054881553051 PKD2/CALM2/FMR1 3 GO:0061912 selective autophagy 3/896 68/18722 0.638075294951993 0.883054881553051 HUWE1/UFL1/SLC25A5 3 GO:1904888 cranial skeletal system development 3/896 68/18722 0.638075294951993 0.883054881553051 CEP55/SETD2/SLC39A1 3 GO:0003197 endocardial cushion development 2/896 45/18722 0.641384507008979 0.883054881553051 BMP7/RBPJ 2 GO:0031670 cellular response to nutrient 2/896 45/18722 0.641384507008979 0.883054881553051 ATP2B1/TRIM24 2 GO:0035305 negative regulation of dephosphorylation 2/896 45/18722 0.641384507008979 0.883054881553051 MASTL/ROCK2 2 GO:0043631 RNA polyadenylation 2/896 45/18722 0.641384507008979 0.883054881553051 APP/AHCYL1 2 GO:0051180 vitamin transport 2/896 45/18722 0.641384507008979 0.883054881553051 LRP2/SLC2A1 2 GO:0060119 inner ear receptor cell development 2/896 45/18722 0.641384507008979 0.883054881553051 TRIP11/TRIOBP 2 GO:0085029 extracellular matrix assembly 2/896 45/18722 0.641384507008979 0.883054881553051 LAMB1/DAG1 2 GO:0019751 polyol metabolic process 5/896 114/18722 0.641892628606852 0.883054881553051 DHFR/SLC5A3/PGP/NUDT4/ISYNA1 5 GO:0002689 negative regulation of leukocyte chemotaxis 1/896 21/18722 0.643146590523661 0.883054881553051 DPP4 1 GO:0006450 regulation of translational fidelity 1/896 21/18722 0.643146590523661 0.883054881553051 IARS2 1 GO:0007252 I-kappaB phosphorylation 1/896 21/18722 0.643146590523661 0.883054881553051 PRDX4 1 GO:0009070 serine family amino acid biosynthetic process 1/896 21/18722 0.643146590523661 0.883054881553051 DHFR 1 GO:0010766 negative regulation of sodium ion transport 1/896 21/18722 0.643146590523661 0.883054881553051 NEDD4 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/896 21/18722 0.643146590523661 0.883054881553051 KHSRP 1 GO:0016075 rRNA catabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 EXOSC8 1 GO:0023019 signal transduction involved in regulation of gene expression 1/896 21/18722 0.643146590523661 0.883054881553051 PARP1 1 GO:0030449 regulation of complement activation 1/896 21/18722 0.643146590523661 0.883054881553051 CD46 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/896 21/18722 0.643146590523661 0.883054881553051 FERMT1 1 GO:0033762 response to glucagon 1/896 21/18722 0.643146590523661 0.883054881553051 CCNA2 1 GO:0034035 purine ribonucleoside bisphosphate metabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 SLC26A2 1 GO:0034312 diol biosynthetic process 1/896 21/18722 0.643146590523661 0.883054881553051 DHFR 1 GO:0035455 response to interferon-alpha 1/896 21/18722 0.643146590523661 0.883054881553051 TPR 1 GO:0035813 regulation of renal sodium excretion 1/896 21/18722 0.643146590523661 0.883054881553051 SNX5 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/896 21/18722 0.643146590523661 0.883054881553051 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/896 21/18722 0.643146590523661 0.883054881553051 SLC5A3 1 GO:0044241 lipid digestion 1/896 21/18722 0.643146590523661 0.883054881553051 LIMA1 1 GO:0045655 regulation of monocyte differentiation 1/896 21/18722 0.643146590523661 0.883054881553051 CDK6 1 GO:0045717 negative regulation of fatty acid biosynthetic process 1/896 21/18722 0.643146590523661 0.883054881553051 BRCA1 1 GO:0046128 purine ribonucleoside metabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 MTAP 1 GO:0046514 ceramide catabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 HEXB 1 GO:0046519 sphingoid metabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 KDSR 1 GO:0046597 negative regulation of viral entry into host cell 1/896 21/18722 0.643146590523661 0.883054881553051 LY6E 1 GO:0046885 regulation of hormone biosynthetic process 1/896 21/18722 0.643146590523661 0.883054881553051 ATP1A1 1 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 SLC26A2 1 GO:0050802 circadian sleep/wake cycle, sleep 1/896 21/18722 0.643146590523661 0.883054881553051 ADRB1 1 GO:0060117 auditory receptor cell development 1/896 21/18722 0.643146590523661 0.883054881553051 TRIOBP 1 GO:0070269 pyroptosis 1/896 21/18722 0.643146590523661 0.883054881553051 DHX9 1 GO:0071498 cellular response to fluid shear stress 1/896 21/18722 0.643146590523661 0.883054881553051 PKD2 1 GO:0071605 monocyte chemotactic protein-1 production 1/896 21/18722 0.643146590523661 0.883054881553051 HMGB1 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/896 21/18722 0.643146590523661 0.883054881553051 HMGB1 1 GO:0072111 cell proliferation involved in kidney development 1/896 21/18722 0.643146590523661 0.883054881553051 BMP7 1 GO:0090141 positive regulation of mitochondrial fission 1/896 21/18722 0.643146590523661 0.883054881553051 AURKA 1 GO:0097062 dendritic spine maintenance 1/896 21/18722 0.643146590523661 0.883054881553051 IGF1R 1 GO:0098698 postsynaptic specialization assembly 1/896 21/18722 0.643146590523661 0.883054881553051 ZDHHC12 1 GO:0098856 intestinal lipid absorption 1/896 21/18722 0.643146590523661 0.883054881553051 LIMA1 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/896 21/18722 0.643146590523661 0.883054881553051 SLC25A5 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/896 21/18722 0.643146590523661 0.883054881553051 ANK3 1 GO:1902644 tertiary alcohol metabolic process 1/896 21/18722 0.643146590523661 0.883054881553051 AKR7A2 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/896 21/18722 0.643146590523661 0.883054881553051 HSPD1 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/896 21/18722 0.643146590523661 0.883054881553051 DDX17 1 GO:0009260 ribonucleotide biosynthetic process 8/896 182/18722 0.647356856400314 0.887797796830144 PARP1/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/TECR 8 GO:0006497 protein lipidation 4/896 92/18722 0.647659383271441 0.887797796830144 PGAP1/GPAA1/ZDHHC12/DBI 4 GO:0048525 negative regulation of viral process 4/896 92/18722 0.647659383271441 0.887797796830144 SRPK1/ILF3/TRIM28/LY6E 4 GO:0003143 embryonic heart tube morphogenesis 3/896 69/18722 0.647902707196528 0.887797796830144 PKD2/YAP1/AHI1 3 GO:0010611 regulation of cardiac muscle hypertrophy 3/896 69/18722 0.647902707196528 0.887797796830144 PARP1/PARP2/ROCK2 3 GO:0019226 transmission of nerve impulse 3/896 69/18722 0.647902707196528 0.887797796830144 ANK3/CNTNAP2/FMR1 3 GO:0050805 negative regulation of synaptic transmission 3/896 69/18722 0.647902707196528 0.887797796830144 SLC6A4/PPP1R9A/FMR1 3 GO:0009117 nucleotide metabolic process 22/896 489/18722 0.648911743962627 0.888925298616236 TYMS/RRM1/DUT/APP/DHTKD1/PARP1/DTYMK/RRM2/GMPS/DLG1/NUDT15/SLC26A2/PPAT/PAICS/UNG/HINT1/SLC25A1/RAN/ACSS1/IDH2/NUDT4/TECR 22 GO:0043271 negative regulation of ion transport 7/896 160/18722 0.649334740325694 0.88924958414081 ANK3/PKD2/GABRE/CALM2/NEDD4/GOPC/FMR1 7 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 11/896 249/18722 0.650350168831737 0.890384773731778 ECT2/WLS/SLC20A1/GJA1/SLC44A2/USP10/ASH1L/BRD4/UFL1/TMED4/TGM2 11 GO:0030099 myeloid cell differentiation 17/896 381/18722 0.652068766441792 0.892481734803072 HMGB2/HMGB1/PRKDC/FBN1/APP/PARP1/LBR/ITGB8/MEIS2/NCAPG2/ACTN1/CDK6/TGFBR3/HSPA9/RBPJ/UFL1/SLC25A5 17 GO:0001974 blood vessel remodeling 2/896 46/18722 0.653309946854217 0.892645016108195 RBPJ/TGM2 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/896 46/18722 0.653309946854217 0.892645016108195 TENM3/CADM1 2 GO:0031648 protein destabilization 2/896 46/18722 0.653309946854217 0.892645016108195 PRKDC/PLK1 2 GO:0043616 keratinocyte proliferation 2/896 46/18722 0.653309946854217 0.892645016108195 FERMT1/YAP1 2 GO:0048701 embryonic cranial skeleton morphogenesis 2/896 46/18722 0.653309946854217 0.892645016108195 SETD2/SLC39A1 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/896 46/18722 0.653309946854217 0.892645016108195 SLC39A10/AURKB 2 GO:0032755 positive regulation of interleukin-6 production 4/896 93/18722 0.65605623229962 0.892919367317514 HMGB1/APP/DHX9/HSPD1 4 GO:0060349 bone morphogenesis 4/896 93/18722 0.65605623229962 0.892919367317514 LRP5/GLG1/TRIP11/SERPINH1 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 4/896 93/18722 0.65605623229962 0.892919367317514 PKD2/CALM2/FMR1/AHNAK 4 GO:1901796 regulation of signal transduction by p53 class mediator 4/896 93/18722 0.65605623229962 0.892919367317514 AURKA/AURKB/CHEK1/TRIM24 4 GO:0006720 isoprenoid metabolic process 5/896 116/18722 0.657045781335732 0.892919367317514 LRP2/EGFR/FDPS/LRP1/ADH5 5 GO:0007006 mitochondrial membrane organization 5/896 116/18722 0.657045781335732 0.892919367317514 HSP90AA1/ARHGAP11B/AFG3L2/HSPA9/SLC25A5 5 GO:1990748 cellular detoxification 5/896 116/18722 0.657045781335732 0.892919367317514 BMP7/DHFR/GPX8/PRDX4/ADH5 5 GO:0002053 positive regulation of mesenchymal cell proliferation 1/896 22/18722 0.660244106960792 0.892919367317514 LRP5 1 GO:0006359 regulation of transcription by RNA polymerase III 1/896 22/18722 0.660244106960792 0.892919367317514 ICE1 1 GO:0006379 mRNA cleavage 1/896 22/18722 0.660244106960792 0.892919367317514 AGO2 1 GO:0006662 glycerol ether metabolic process 1/896 22/18722 0.660244106960792 0.892919367317514 CHPT1 1 GO:0006907 pinocytosis 1/896 22/18722 0.660244106960792 0.892919367317514 SNX5 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/896 22/18722 0.660244106960792 0.892919367317514 SPESP1 1 GO:0007398 ectoderm development 1/896 22/18722 0.660244106960792 0.892919367317514 ITGA6 1 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1/896 22/18722 0.660244106960792 0.892919367317514 CALM2 1 GO:0014821 phasic smooth muscle contraction 1/896 22/18722 0.660244106960792 0.892919367317514 DLG1 1 GO:0019400 alditol metabolic process 1/896 22/18722 0.660244106960792 0.892919367317514 PGP 1 GO:0031281 positive regulation of cyclase activity 1/896 22/18722 0.660244106960792 0.892919367317514 NF1 1 GO:0035089 establishment of apical/basal cell polarity 1/896 22/18722 0.660244106960792 0.892919367317514 FAT1 1 GO:0035357 peroxisome proliferator activated receptor signaling pathway 1/896 22/18722 0.660244106960792 0.892919367317514 ASXL1 1 GO:0042749 regulation of circadian sleep/wake cycle 1/896 22/18722 0.660244106960792 0.892919367317514 ADRB1 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/896 22/18722 0.660244106960792 0.892919367317514 HMGB1 1 GO:0044346 fibroblast apoptotic process 1/896 22/18722 0.660244106960792 0.892919367317514 XRCC2 1 GO:0048169 regulation of long-term neuronal synaptic plasticity 1/896 22/18722 0.660244106960792 0.892919367317514 APP 1 GO:0050860 negative regulation of T cell receptor signaling pathway 1/896 22/18722 0.660244106960792 0.892919367317514 PAWR 1 GO:0051151 negative regulation of smooth muscle cell differentiation 1/896 22/18722 0.660244106960792 0.892919367317514 DNMT1 1 GO:0055093 response to hyperoxia 1/896 22/18722 0.660244106960792 0.892919367317514 HDAC2 1 GO:0060444 branching involved in mammary gland duct morphogenesis 1/896 22/18722 0.660244106960792 0.892919367317514 LRP5 1 GO:0060563 neuroepithelial cell differentiation 1/896 22/18722 0.660244106960792 0.892919367317514 SOX4 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/896 22/18722 0.660244106960792 0.892919367317514 ITGB1 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/896 22/18722 0.660244106960792 0.892919367317514 ANK3 1 GO:0099563 modification of synaptic structure 1/896 22/18722 0.660244106960792 0.892919367317514 MYH10 1 GO:0140467 integrated stress response signaling 1/896 22/18722 0.660244106960792 0.892919367317514 HSPA5 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/896 22/18722 0.660244106960792 0.892919367317514 PARP1 1 GO:1901032 negative regulation of response to reactive oxygen species 1/896 22/18722 0.660244106960792 0.892919367317514 MET 1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 1/896 22/18722 0.660244106960792 0.892919367317514 RBPJ 1 GO:0045444 fat cell differentiation 10/896 229/18722 0.661665569470444 0.89458834003169 BMP7/LRP5/ADRB1/CCND1/CDS1/KLF5/YAP1/ASXL1/HNRNPU/ADIRF 10 GO:0021953 central nervous system neuron differentiation 7/896 162/18722 0.662103644975008 0.894673875208233 NRP2/HSP90AA1/NRP1/NFIB/SOX4/LMO4/HSP90AB1 7 GO:0051100 negative regulation of binding 7/896 162/18722 0.662103644975008 0.894673875208233 AURKA/AURKB/NEK2/ATP2A2/ID1/HDAC2/LRPAP1 7 GO:0048704 embryonic skeletal system morphogenesis 4/896 94/18722 0.664317513541407 0.896192279838633 BMP7/DLG1/SETD2/SLC39A1 4 GO:0050890 cognition 13/896 296/18722 0.664461945045696 0.896192279838633 EGFR/APP/MME/ITGB1/FEN1/TPBG/CNTNAP2/MEIS2/SLC6A4/NF1/VLDLR/TUSC3/SERPINF1 13 GO:0009261 ribonucleotide catabolic process 2/896 47/18722 0.664916852783502 0.896192279838633 HINT1/NUDT4 2 GO:0010761 fibroblast migration 2/896 47/18722 0.664916852783502 0.896192279838633 ITGB1/PDLIM1 2 GO:0019884 antigen processing and presentation of exogenous antigen 2/896 47/18722 0.664916852783502 0.896192279838633 CTSV/CTSL 2 GO:0045332 phospholipid translocation 2/896 47/18722 0.664916852783502 0.896192279838633 TMEM30B/ANO6 2 GO:0047496 vesicle transport along microtubule 2/896 47/18722 0.664916852783502 0.896192279838633 DYNC1H1/KIF5B 2 GO:0048512 circadian behavior 2/896 47/18722 0.664916852783502 0.896192279838633 ADRB1/ZFHX3 2 GO:0050798 activated T cell proliferation 2/896 47/18722 0.664916852783502 0.896192279838633 HMGB1/CD24 2 GO:0046165 alcohol biosynthetic process 6/896 140/18722 0.666032947456213 0.897443209471059 DHFR/LBR/DHCR24/PGP/FDPS/ISYNA1 6 GO:0032722 positive regulation of chemokine production 3/896 71/18722 0.666983688995201 0.898470691665658 HMGB1/APP/LRP1 3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 8/896 186/18722 0.671181298678916 0.89914318728927 ECT2/WLS/SLC20A1/GJA1/SLC44A2/BRD4/TMED4/TGM2 8 GO:0008593 regulation of Notch signaling pathway 4/896 95/18722 0.672442512600963 0.89914318728927 GALNT11/BMP7/CD46/YAP1 4 GO:0048709 oligodendrocyte differentiation 4/896 95/18722 0.672442512600963 0.89914318728927 DAG1/NF1/HDAC2/RHEB 4 GO:0030183 B cell differentiation 6/896 141/18722 0.672729996708596 0.89914318728927 PRKDC/EZH2/ITGB1/MSH2/RBPJ/SLC25A5 6 GO:0050921 positive regulation of chemotaxis 6/896 141/18722 0.672729996708596 0.89914318728927 HMGB1/MET/NRP1/TPBG/CALR/ANO6 6 GO:0045765 regulation of angiogenesis 15/896 342/18722 0.67293649337388 0.89914318728927 HMGB1/BRCA1/ITGB1/NRP1/AMOT/COL4A2/ITGB8/ADAMTS1/EMP2/SEMA6A/NF1/ROCK2/AGO2/PTPRM/SERPINF1 15 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/896 209/18722 0.674248684731189 0.89914318728927 HMGB1/BIRC5/DHCR24/CASP8AP2/ARL6IP1/BCL2L12/HSPD1/ANP32B/USP47 9 GO:0033628 regulation of cell adhesion mediated by integrin 2/896 48/18722 0.676208363793856 0.89914318728927 DPP4/FERMT1 2 GO:0042149 cellular response to glucose starvation 2/896 48/18722 0.676208363793856 0.89914318728927 HSPA5/SLC2A1 2 GO:0042908 xenobiotic transport 2/896 48/18722 0.676208363793856 0.89914318728927 GJA1/SLC2A1 2 GO:1902003 regulation of amyloid-beta formation 2/896 48/18722 0.676208363793856 0.89914318728927 ROCK2/RTN4 2 GO:0001736 establishment of planar polarity 3/896 72/18722 0.676236871945769 0.89914318728927 ZNRF3/FZD6/RYK 3 GO:0005977 glycogen metabolic process 3/896 72/18722 0.676236871945769 0.89914318728927 HMGB1/AGL/PHKB 3 GO:0007164 establishment of tissue polarity 3/896 72/18722 0.676236871945769 0.89914318728927 ZNRF3/FZD6/RYK 3 GO:0014743 regulation of muscle hypertrophy 3/896 72/18722 0.676236871945769 0.89914318728927 PARP1/PARP2/ROCK2 3 GO:0050709 negative regulation of protein secretion 3/896 72/18722 0.676236871945769 0.89914318728927 FRMD4A/IDH2/ERP29 3 GO:0002052 positive regulation of neuroblast proliferation 1/896 23/18722 0.676523319803741 0.89914318728927 ASPM 1 GO:0002363 alpha-beta T cell lineage commitment 1/896 23/18722 0.676523319803741 0.89914318728927 CTSL 1 GO:0007130 synaptonemal complex assembly 1/896 23/18722 0.676523319803741 0.89914318728927 RAD21 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/896 23/18722 0.676523319803741 0.89914318728927 LRP1 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/896 23/18722 0.676523319803741 0.89914318728927 PABPN1 1 GO:0021544 subpallium development 1/896 23/18722 0.676523319803741 0.89914318728927 CNTNAP2 1 GO:0030194 positive regulation of blood coagulation 1/896 23/18722 0.676523319803741 0.89914318728927 ANO6 1 GO:0031280 negative regulation of cyclase activity 1/896 23/18722 0.676523319803741 0.89914318728927 AKAP9 1 GO:0031338 regulation of vesicle fusion 1/896 23/18722 0.676523319803741 0.89914318728927 KIF5B 1 GO:0034105 positive regulation of tissue remodeling 1/896 23/18722 0.676523319803741 0.89914318728927 ROCK2 1 GO:0034695 response to prostaglandin E 1/896 23/18722 0.676523319803741 0.89914318728927 TGFBR3 1 GO:0035162 embryonic hemopoiesis 1/896 23/18722 0.676523319803741 0.89914318728927 PBX1 1 GO:0035640 exploration behavior 1/896 23/18722 0.676523319803741 0.89914318728927 DPP4 1 GO:0035812 renal sodium excretion 1/896 23/18722 0.676523319803741 0.89914318728927 SNX5 1 GO:0035988 chondrocyte proliferation 1/896 23/18722 0.676523319803741 0.89914318728927 GOLGB1 1 GO:0040019 positive regulation of embryonic development 1/896 23/18722 0.676523319803741 0.89914318728927 AMOT 1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1/896 23/18722 0.676523319803741 0.89914318728927 NEDD4 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/896 23/18722 0.676523319803741 0.89914318728927 CTSL 1 GO:0043931 ossification involved in bone maturation 1/896 23/18722 0.676523319803741 0.89914318728927 PLXNB1 1 GO:0045662 negative regulation of myoblast differentiation 1/896 23/18722 0.676523319803741 0.89914318728927 MBNL3 1 GO:0045980 negative regulation of nucleotide metabolic process 1/896 23/18722 0.676523319803741 0.89914318728927 PARP1 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/896 23/18722 0.676523319803741 0.89914318728927 CHPF 1 GO:0050765 negative regulation of phagocytosis 1/896 23/18722 0.676523319803741 0.89914318728927 HMGB1 1 GO:0051349 positive regulation of lyase activity 1/896 23/18722 0.676523319803741 0.89914318728927 NF1 1 GO:0051446 positive regulation of meiotic cell cycle 1/896 23/18722 0.676523319803741 0.89914318728927 RAD51AP1 1 GO:0051590 positive regulation of neurotransmitter transport 1/896 23/18722 0.676523319803741 0.89914318728927 ITGB1 1 GO:0060353 regulation of cell adhesion molecule production 1/896 23/18722 0.676523319803741 0.89914318728927 COLEC12 1 GO:0060384 innervation 1/896 23/18722 0.676523319803741 0.89914318728927 NRP1 1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 1/896 23/18722 0.676523319803741 0.89914318728927 PARP2 1 GO:1900048 positive regulation of hemostasis 1/896 23/18722 0.676523319803741 0.89914318728927 ANO6 1 GO:1903306 negative regulation of regulated secretory pathway 1/896 23/18722 0.676523319803741 0.89914318728927 FMR1 1 GO:2001169 regulation of ATP biosynthetic process 1/896 23/18722 0.676523319803741 0.89914318728927 PARP1 1 GO:0046467 membrane lipid biosynthetic process 6/896 142/18722 0.679340689820025 0.902636363262121 HACD3/PGAP1/GPAA1/DEGS1/KDSR/ORMDL1 6 GO:0042158 lipoprotein biosynthetic process 4/896 96/18722 0.68043068401443 0.903581664947118 PGAP1/GPAA1/ZDHHC12/DBI 4 GO:0042632 cholesterol homeostasis 4/896 96/18722 0.68043068401443 0.903581664947118 TMEM97/LRP5/LIMA1/CD24 4 GO:0002637 regulation of immunoglobulin production 3/896 73/18722 0.68529871140577 0.905491396525779 PRKDC/RIF1/MSH2 3 GO:0006073 cellular glucan metabolic process 3/896 73/18722 0.68529871140577 0.905491396525779 HMGB1/AGL/PHKB 3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 3/896 73/18722 0.68529871140577 0.905491396525779 LRP5/KIF5B/LRP1 3 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 3/896 73/18722 0.68529871140577 0.905491396525779 EGFR/DGKD/SNX5 3 GO:0044042 glucan metabolic process 3/896 73/18722 0.68529871140577 0.905491396525779 HMGB1/AGL/PHKB 3 GO:0099518 vesicle cytoskeletal trafficking 3/896 73/18722 0.68529871140577 0.905491396525779 MYO1C/DYNC1H1/KIF5B 3 GO:0034763 negative regulation of transmembrane transport 6/896 143/18722 0.685864433615665 0.905491396525779 ANK3/PKD2/CALM2/NEDD4/GOPC/FMR1 6 GO:0000959 mitochondrial RNA metabolic process 2/896 49/18722 0.687188047865551 0.905491396525779 TFAM/LRPPRC 2 GO:0002762 negative regulation of myeloid leukocyte differentiation 2/896 49/18722 0.687188047865551 0.905491396525779 FBN1/CDK6 2 GO:0007622 rhythmic behavior 2/896 49/18722 0.687188047865551 0.905491396525779 ADRB1/ZFHX3 2 GO:0010823 negative regulation of mitochondrion organization 2/896 49/18722 0.687188047865551 0.905491396525779 HUWE1/SLC25A5 2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 2/896 49/18722 0.687188047865551 0.905491396525779 BMP7/TTK 2 GO:0021515 cell differentiation in spinal cord 2/896 49/18722 0.687188047865551 0.905491396525779 SOX4/LMO4 2 GO:0030225 macrophage differentiation 2/896 49/18722 0.687188047865551 0.905491396525779 APP/PARP1 2 GO:0042461 photoreceptor cell development 2/896 49/18722 0.687188047865551 0.905491396525779 AHI1/TUG1 2 GO:0043330 response to exogenous dsRNA 2/896 49/18722 0.687188047865551 0.905491396525779 COLEC12/DHX9 2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/896 49/18722 0.687188047865551 0.905491396525779 HMGB2/BRCA1 2 GO:1990928 response to amino acid starvation 2/896 49/18722 0.687188047865551 0.905491396525779 SLC38A2/LARP1 2 GO:0042886 amide transport 13/896 301/18722 0.687507794920593 0.905491396525779 LRP2/EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/SLC13A3/FAM3B 13 GO:0010596 negative regulation of endothelial cell migration 4/896 97/18722 0.688281644030581 0.905491396525779 HMGB1/NR2F2/PTPRM/SERPINF1 4 GO:0035335 peptidyl-tyrosine dephosphorylation 4/896 97/18722 0.688281644030581 0.905491396525779 CDKN3/PTPN14/PTPRM/PGP 4 GO:0055092 sterol homeostasis 4/896 97/18722 0.688281644030581 0.905491396525779 TMEM97/LRP5/LIMA1/CD24 4 GO:0006469 negative regulation of protein kinase activity 9/896 212/18722 0.690465582261738 0.905491396525779 BMP7/IPO7/NR2F2/PLK1/LRP5/IPO5/NCAPG2/NF1/CDKN2A 9 GO:0000395 mRNA 5'-splice site recognition 1/896 24/18722 0.69202335218279 0.905491396525779 PSIP1 1 GO:0001779 natural killer cell differentiation 1/896 24/18722 0.69202335218279 0.905491396525779 PBX1 1 GO:0002021 response to dietary excess 1/896 24/18722 0.69202335218279 0.905491396525779 ADRB1 1 GO:0002726 positive regulation of T cell cytokine production 1/896 24/18722 0.69202335218279 0.905491396525779 FZD5 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/896 24/18722 0.69202335218279 0.905491396525779 HSPD1 1 GO:0003181 atrioventricular valve morphogenesis 1/896 24/18722 0.69202335218279 0.905491396525779 SOX4 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/896 24/18722 0.69202335218279 0.905491396525779 ZDHHC12 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/896 24/18722 0.69202335218279 0.905491396525779 ZDHHC12 1 GO:0022410 circadian sleep/wake cycle process 1/896 24/18722 0.69202335218279 0.905491396525779 ADRB1 1 GO:0031639 plasminogen activation 1/896 24/18722 0.69202335218279 0.905491396525779 DHCR24 1 GO:0032528 microvillus organization 1/896 24/18722 0.69202335218279 0.905491396525779 KLF5 1 GO:0032928 regulation of superoxide anion generation 1/896 24/18722 0.69202335218279 0.905491396525779 EGFR 1 GO:0033032 regulation of myeloid cell apoptotic process 1/896 24/18722 0.69202335218279 0.905491396525779 CDKN2A 1 GO:0035458 cellular response to interferon-beta 1/896 24/18722 0.69202335218279 0.905491396525779 UBE2G2 1 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/896 24/18722 0.69202335218279 0.905491396525779 PUM1 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/896 24/18722 0.69202335218279 0.905491396525779 PHIP 1 GO:0044062 regulation of excretion 1/896 24/18722 0.69202335218279 0.905491396525779 SNX5 1 GO:0050820 positive regulation of coagulation 1/896 24/18722 0.69202335218279 0.905491396525779 ANO6 1 GO:0050855 regulation of B cell receptor signaling pathway 1/896 24/18722 0.69202335218279 0.905491396525779 SLC39A10 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/896 24/18722 0.69202335218279 0.905491396525779 DHFR 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/896 24/18722 0.69202335218279 0.905491396525779 HMGB1 1 GO:0060571 morphogenesis of an epithelial fold 1/896 24/18722 0.69202335218279 0.905491396525779 BMP7 1 GO:0061162 establishment of monopolar cell polarity 1/896 24/18722 0.69202335218279 0.905491396525779 FAT1 1 GO:0070129 regulation of mitochondrial translation 1/896 24/18722 0.69202335218279 0.905491396525779 LRPPRC 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/896 24/18722 0.69202335218279 0.905491396525779 SLC5A3 1 GO:2000209 regulation of anoikis 1/896 24/18722 0.69202335218279 0.905491396525779 ITGB1 1 GO:2000310 regulation of NMDA receptor activity 1/896 24/18722 0.69202335218279 0.905491396525779 APP 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/896 24/18722 0.69202335218279 0.905491396525779 ANO6 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/896 24/18722 0.69202335218279 0.905491396525779 PARP1 1 GO:2001026 regulation of endothelial cell chemotaxis 1/896 24/18722 0.69202335218279 0.905491396525779 MET 1 GO:0007612 learning 6/896 144/18722 0.692300711629471 0.905491396525779 APP/ITGB1/TPBG/CNTNAP2/MEIS2/NF1 6 GO:0033135 regulation of peptidyl-serine phosphorylation 6/896 144/18722 0.692300711629471 0.905491396525779 EGFR/APP/HSP90AA1/AKAP9/EIF4G1/HSP90AB1 6 GO:0002224 toll-like receptor signaling pathway 5/896 121/18722 0.693088330545178 0.906273264865154 HMGB1/COLEC12/LGR4/HSPD1/RTN4 5 GO:0046390 ribose phosphate biosynthetic process 8/896 190/18722 0.694005219850056 0.906445841318381 PARP1/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/TECR 8 GO:0051216 cartilage development 8/896 190/18722 0.694005219850056 0.906445841318381 TYMS/EFEMP1/BMP7/ITGB8/NFIB/GLG1/TRIP11/SERPINH1 8 GO:0006801 superoxide metabolic process 3/896 74/18722 0.69416966817344 0.906445841318381 EGFR/BMP7/DHFR 3 GO:0030968 endoplasmic reticulum unfolded protein response 3/896 74/18722 0.69416966817344 0.906445841318381 CCND1/HSPA5/UFL1 3 GO:0051881 regulation of mitochondrial membrane potential 3/896 74/18722 0.69416966817344 0.906445841318381 PARP1/GCLM/SLC25A36 3 GO:0032642 regulation of chemokine production 4/896 98/18722 0.69599516347924 0.908581052898521 HMGB1/APP/SUZ12/LRP1 4 GO:0002639 positive regulation of immunoglobulin production 2/896 50/18722 0.697859853806863 0.909523052709245 RIF1/MSH2 2 GO:0008089 anterograde axonal transport 2/896 50/18722 0.697859853806863 0.909523052709245 KIF4A/KIF5B 2 GO:0043628 ncRNA 3'-end processing 2/896 50/18722 0.697859853806863 0.909523052709245 EXOSC8/RPS21 2 GO:0090102 cochlea development 2/896 50/18722 0.697859853806863 0.909523052709245 CCNA2/MCM2 2 GO:0099054 presynapse assembly 2/896 50/18722 0.697859853806863 0.909523052709245 APP/EIF4G1 2 GO:1901570 fatty acid derivative biosynthetic process 2/896 50/18722 0.697859853806863 0.909523052709245 SLC25A1/TECR 2 GO:0002706 regulation of lymphocyte mediated immunity 7/896 168/18722 0.698672356853188 0.910333469327816 HMGB1/CADM1/RIF1/MSH2/FZD5/CD46/HSPD1 7 GO:0006164 purine nucleotide biosynthetic process 8/896 191/18722 0.699551011993435 0.91122961289404 PARP1/GMPS/SLC26A2/PPAT/PAICS/SLC25A1/ACSS1/TECR 8 GO:0051208 sequestering of calcium ion 5/896 122/18722 0.699976480696276 0.911535111523192 HSP90B1/MCOLN3/PKD2/CALM2/CALR 5 GO:1903532 positive regulation of secretion by cell 12/896 282/18722 0.702666910960509 0.913667664238922 MYH10/EGFR/WLS/GJA1/EXPH5/SOX4/SLC6A4/FRMD4A/TM7SF3/KIF5B/CD2AP/LRP1 12 GO:0033673 negative regulation of kinase activity 10/896 237/18722 0.702821798985435 0.913667664238922 BMP7/IPO7/NR2F2/PLK1/LRP5/IPO5/NCAPG2/NF1/CDKN2A/HNRNPU 10 GO:0034121 regulation of toll-like receptor signaling pathway 3/896 75/18722 0.702850435226459 0.913667664238922 HMGB1/LGR4/RTN4 3 GO:0045913 positive regulation of carbohydrate metabolic process 3/896 75/18722 0.702850435226459 0.913667664238922 HMGB1/APP/DDB1 3 GO:0055074 calcium ion homeostasis 20/896 460/18722 0.703265739765213 0.913667664238922 HMGB1/HSP90B1/ATP2B1/APP/ITGAV/MCOLN3/GJA1/PKD2/ATP13A3/CALM2/ATP2A2/CCDC47/TRIM24/AFG3L2/CALR/HEXB/LRP1/CD24/TMEM165/TGM2 20 GO:0032602 chemokine production 4/896 99/18722 0.703571160739502 0.913667664238922 HMGB1/APP/SUZ12/LRP1 4 GO:0010675 regulation of cellular carbohydrate metabolic process 6/896 146/18722 0.704909175520193 0.913667664238922 HMGB1/SLC35B4/SOGA1/PGP/RANBP2/DDB1 6 GO:0032872 regulation of stress-activated MAPK cascade 8/896 192/18722 0.705031922494773 0.913667664238922 HMGB1/EGFR/APP/PBK/MARVELD3/IGF1R/FOXM1/DLG1 8 GO:0010447 response to acidic pH 1/896 25/18722 0.706781458742006 0.913667664238922 SERPINF1 1 GO:0032104 regulation of response to extracellular stimulus 1/896 25/18722 0.706781458742006 0.913667664238922 TRIM24 1 GO:0032107 regulation of response to nutrient levels 1/896 25/18722 0.706781458742006 0.913667664238922 TRIM24 1 GO:0032331 negative regulation of chondrocyte differentiation 1/896 25/18722 0.706781458742006 0.913667664238922 EFEMP1 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/896 25/18722 0.706781458742006 0.913667664238922 TECR 1 GO:0036315 cellular response to sterol 1/896 25/18722 0.706781458742006 0.913667664238922 DAG1 1 GO:0045109 intermediate filament organization 1/896 25/18722 0.706781458742006 0.913667664238922 DSP 1 GO:0046039 GTP metabolic process 1/896 25/18722 0.706781458742006 0.913667664238922 RAN 1 GO:0046339 diacylglycerol metabolic process 1/896 25/18722 0.706781458742006 0.913667664238922 DGKD 1 GO:0051204 protein insertion into mitochondrial membrane 1/896 25/18722 0.706781458742006 0.913667664238922 HSP90AA1 1 GO:0060740 prostate gland epithelium morphogenesis 1/896 25/18722 0.706781458742006 0.913667664238922 BMP7 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/896 25/18722 0.706781458742006 0.913667664238922 FAT1 1 GO:0072012 glomerulus vasculature development 1/896 25/18722 0.706781458742006 0.913667664238922 BMP7 1 GO:0086013 membrane repolarization during cardiac muscle cell action potential 1/896 25/18722 0.706781458742006 0.913667664238922 ATP1A1 1 GO:1902993 positive regulation of amyloid precursor protein catabolic process 1/896 25/18722 0.706781458742006 0.913667664238922 ROCK2 1 GO:1903055 positive regulation of extracellular matrix organization 1/896 25/18722 0.706781458742006 0.913667664238922 DAG1 1 GO:1903901 negative regulation of viral life cycle 1/896 25/18722 0.706781458742006 0.913667664238922 LY6E 1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 1/896 25/18722 0.706781458742006 0.913667664238922 NFAT5 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/896 25/18722 0.706781458742006 0.913667664238922 HMGB1 1 GO:0010656 negative regulation of muscle cell apoptotic process 2/896 51/18722 0.708228066716767 0.914794586175824 BMP7/DNMT1 2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 2/896 51/18722 0.708228066716767 0.914794586175824 USP10/ASH1L 2 GO:0051339 regulation of lyase activity 2/896 51/18722 0.708228066716767 0.914794586175824 NF1/AKAP9 2 GO:0009062 fatty acid catabolic process 4/896 100/18722 0.711009694818524 0.917734314558837 SLC27A2/ACAT2/ECHDC2/HADHA 4 GO:0051588 regulation of neurotransmitter transport 4/896 100/18722 0.711009694818524 0.917734314558837 ITGB1/ATP2A2/PPP1R9A/FMR1 4 GO:1903531 negative regulation of secretion by cell 6/896 147/18722 0.711080693245316 0.917734314558837 GJA1/FRMD4A/PPP1R9A/FMR1/IDH2/ERP29 6 GO:0002377 immunoglobulin production 9/896 216/18722 0.711294101024992 0.917761631971165 PRKDC/RIF1/MSH6/POLQ/MSH2/RNF168/UNG/HSPD1/CTNNBL1 9 GO:0001909 leukocyte mediated cytotoxicity 5/896 124/18722 0.713429646754878 0.918893802394139 TUBB/TUBB4B/CADM1/EMP2/KIF5B 5 GO:0002285 lymphocyte activation involved in immune response 8/896 194/18722 0.715797824787449 0.918893802394139 HMGB1/RIF1/MSH6/MSH2/RNF168/CD46/UNG/HSPD1 8 GO:0007596 blood coagulation 9/896 217/18722 0.716357141464165 0.918893802394139 F5/LMAN1/DGKD/FZD6/FBLN1/VCL/VKORC1/HPS5/ANO6 9 GO:0002181 cytoplasmic translation 6/896 148/18722 0.717163404663592 0.918893802394139 EIF3A/DHX9/EIF4G1/FMR1/RPS21/RPS17 6 GO:2001056 positive regulation of cysteine-type endopeptidase activity 6/896 148/18722 0.717163404663592 0.918893802394139 HMGB1/PERP/ASPH/CASP8AP2/HSPD1/ANP32B 6 GO:0021545 cranial nerve development 2/896 52/18722 0.718297266830171 0.918893802394139 NRP2/NRP1 2 GO:0034204 lipid translocation 2/896 52/18722 0.718297266830171 0.918893802394139 TMEM30B/ANO6 2 GO:0051496 positive regulation of stress fiber assembly 2/896 52/18722 0.718297266830171 0.918893802394139 NRP1/ROCK2 2 GO:0072132 mesenchyme morphogenesis 2/896 52/18722 0.718297266830171 0.918893802394139 BMP7/RBPJ 2 GO:1903426 regulation of reactive oxygen species biosynthetic process 2/896 52/18722 0.718297266830171 0.918893802394139 SLC5A3/HSPD1 2 GO:2000378 negative regulation of reactive oxygen species metabolic process 2/896 52/18722 0.718297266830171 0.918893802394139 BRCA1/HSPD1 2 GO:0006476 protein deacetylation 4/896 101/18722 0.71831095855054 0.918893802394139 NCAPG2/SFPQ/TBL1X/HDAC2 4 GO:0098869 cellular oxidant detoxification 4/896 101/18722 0.71831095855054 0.918893802394139 BMP7/DHFR/GPX8/PRDX4 4 GO:0140056 organelle localization by membrane tethering 3/896 77/18722 0.719645240726824 0.918893802394139 RAB3IP/ATP2A2/AHCYL1 3 GO:0001963 synaptic transmission, dopaminergic 1/896 26/18722 0.720833114781326 0.918893802394139 SLC6A4 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/896 26/18722 0.720833114781326 0.918893802394139 GABRE 1 GO:0010875 positive regulation of cholesterol efflux 1/896 26/18722 0.720833114781326 0.918893802394139 LRP1 1 GO:0014829 vascular associated smooth muscle contraction 1/896 26/18722 0.720833114781326 0.918893802394139 ATP2B1 1 GO:0016226 iron-sulfur cluster assembly 1/896 26/18722 0.720833114781326 0.918893802394139 HSPA9 1 GO:0021952 central nervous system projection neuron axonogenesis 1/896 26/18722 0.720833114781326 0.918893802394139 NFIB 1 GO:0031163 metallo-sulfur cluster assembly 1/896 26/18722 0.720833114781326 0.918893802394139 HSPA9 1 GO:0032682 negative regulation of chemokine production 1/896 26/18722 0.720833114781326 0.918893802394139 SUZ12 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/896 26/18722 0.720833114781326 0.918893802394139 LRPPRC 1 GO:0042278 purine nucleoside metabolic process 1/896 26/18722 0.720833114781326 0.918893802394139 MTAP 1 GO:0042634 regulation of hair cycle 1/896 26/18722 0.720833114781326 0.918893802394139 FERMT1 1 GO:0043094 cellular metabolic compound salvage 1/896 26/18722 0.720833114781326 0.918893802394139 MTAP 1 GO:0045026 plasma membrane fusion 1/896 26/18722 0.720833114781326 0.918893802394139 SPESP1 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/896 26/18722 0.720833114781326 0.918893802394139 CADM1 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/896 26/18722 0.720833114781326 0.918893802394139 HMGB1 1 GO:0046755 viral budding 1/896 26/18722 0.720833114781326 0.918893802394139 NEDD4 1 GO:0047497 mitochondrion transport along microtubule 1/896 26/18722 0.720833114781326 0.918893802394139 LRPPRC 1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 1/896 26/18722 0.720833114781326 0.918893802394139 SLC39A10 1 GO:0051350 negative regulation of lyase activity 1/896 26/18722 0.720833114781326 0.918893802394139 AKAP9 1 GO:0060037 pharyngeal system development 1/896 26/18722 0.720833114781326 0.918893802394139 BMP7 1 GO:0060352 cell adhesion molecule production 1/896 26/18722 0.720833114781326 0.918893802394139 COLEC12 1 GO:0070102 interleukin-6-mediated signaling pathway 1/896 26/18722 0.720833114781326 0.918893802394139 YAP1 1 GO:0070977 bone maturation 1/896 26/18722 0.720833114781326 0.918893802394139 PLXNB1 1 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1/896 26/18722 0.720833114781326 0.918893802394139 ADRB1 1 GO:0097186 amelogenesis 1/896 26/18722 0.720833114781326 0.918893802394139 PERP 1 GO:0099637 neurotransmitter receptor transport 1/896 26/18722 0.720833114781326 0.918893802394139 CLSTN1 1 GO:1901071 glucosamine-containing compound metabolic process 1/896 26/18722 0.720833114781326 0.918893802394139 EXTL2 1 GO:1904861 excitatory synapse assembly 1/896 26/18722 0.720833114781326 0.918893802394139 ZDHHC12 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/896 26/18722 0.720833114781326 0.918893802394139 DNMT1 1 GO:2000050 regulation of non-canonical Wnt signaling pathway 1/896 26/18722 0.720833114781326 0.918893802394139 ZNRF3 1 GO:2000108 positive regulation of leukocyte apoptotic process 1/896 26/18722 0.720833114781326 0.918893802394139 CDKN2A 1 GO:0070302 regulation of stress-activated protein kinase signaling cascade 8/896 195/18722 0.721082281622042 0.918966047107215 HMGB1/EGFR/APP/PBK/MARVELD3/IGF1R/FOXM1/DLG1 8 GO:0007219 Notch signaling pathway 7/896 172/18722 0.721563193592599 0.91933351646946 GALNT11/APP/PERP/BMP7/CD46/YAP1/RBPJ 7 GO:0006672 ceramide metabolic process 4/896 102/18722 0.725475271924618 0.923824739442019 ITGB8/DEGS1/HEXB/ORMDL1 4 GO:0062014 negative regulation of small molecule metabolic process 4/896 102/18722 0.725475271924618 0.923824739442019 PARP1/BRCA1/SOGA1/PGP 4 GO:0006006 glucose metabolic process 8/896 196/18722 0.726300785080063 0.924629319459258 HMGB1/SLC35B4/LRP5/SOGA1/PGP/SLC25A1/RANBP2/DDB1 8 GO:0051047 positive regulation of secretion 13/896 310/18722 0.726569218119722 0.9247244594251 MYH10/EGFR/WLS/GJA1/EXPH5/SOX4/SLC6A4/FRMD4A/SNX5/TM7SF3/KIF5B/CD2AP/LRP1 13 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 3/896 78/18722 0.727761689635273 0.92515760440194 CASP8AP2/HSPD1/ANP32B 3 GO:0034637 cellular carbohydrate biosynthetic process 3/896 78/18722 0.727761689635273 0.92515760440194 AGL/PGP/ISYNA1 3 GO:0035050 embryonic heart tube development 3/896 78/18722 0.727761689635273 0.92515760440194 PKD2/YAP1/AHI1 3 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/896 53/18722 0.728072291524526 0.92515760440194 STMN1/MET 2 GO:0045806 negative regulation of endocytosis 2/896 53/18722 0.728072291524526 0.92515760440194 ITGAV/LRPAP1 2 GO:0099172 presynapse organization 2/896 53/18722 0.728072291524526 0.92515760440194 APP/EIF4G1 2 GO:0042594 response to starvation 8/896 197/18722 0.731453165501956 0.927282690712153 CTSV/SLC38A2/TNRC6A/HSPA5/LARP1/STK24/SLC2A1/HSPA8 8 GO:0030148 sphingolipid biosynthetic process 4/896 103/18722 0.7325030755487 0.927282690712153 HACD3/DEGS1/KDSR/ORMDL1 4 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 4/896 103/18722 0.7325030755487 0.927282690712153 SUZ12/CENPJ/PRLR/OCIAD1 4 GO:0000737 DNA catabolic process, endonucleolytic 1/896 27/18722 0.734212101150385 0.927282690712153 DICER1 1 GO:0001835 blastocyst hatching 1/896 27/18722 0.734212101150385 0.927282690712153 ASF1B 1 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1/896 27/18722 0.734212101150385 0.927282690712153 YES1 1 GO:0007263 nitric oxide mediated signal transduction 1/896 27/18722 0.734212101150385 0.927282690712153 EGFR 1 GO:0007628 adult walking behavior 1/896 27/18722 0.734212101150385 0.927282690712153 OXR1 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/896 27/18722 0.734212101150385 0.927282690712153 AGO2 1 GO:0010894 negative regulation of steroid biosynthetic process 1/896 27/18722 0.734212101150385 0.927282690712153 ATP1A1 1 GO:0016556 mRNA modification 1/896 27/18722 0.734212101150385 0.927282690712153 ZC3H13 1 GO:0018904 ether metabolic process 1/896 27/18722 0.734212101150385 0.927282690712153 CHPT1 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/896 27/18722 0.734212101150385 0.927282690712153 HMGB1 1 GO:0035188 hatching 1/896 27/18722 0.734212101150385 0.927282690712153 ASF1B 1 GO:0035235 ionotropic glutamate receptor signaling pathway 1/896 27/18722 0.734212101150385 0.927282690712153 APP 1 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 1/896 27/18722 0.734212101150385 0.927282690712153 YES1 1 GO:0039529 RIG-I signaling pathway 1/896 27/18722 0.734212101150385 0.927282690712153 PUM1 1 GO:0042745 circadian sleep/wake cycle 1/896 27/18722 0.734212101150385 0.927282690712153 ADRB1 1 GO:0045606 positive regulation of epidermal cell differentiation 1/896 27/18722 0.734212101150385 0.927282690712153 NCOA3 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/896 27/18722 0.734212101150385 0.927282690712153 HSP90AB1 1 GO:0060512 prostate gland morphogenesis 1/896 27/18722 0.734212101150385 0.927282690712153 BMP7 1 GO:0071684 organism emergence from protective structure 1/896 27/18722 0.734212101150385 0.927282690712153 ASF1B 1 GO:1903319 positive regulation of protein maturation 1/896 27/18722 0.734212101150385 0.927282690712153 SOX4 1 GO:0070588 calcium ion transmembrane transport 13/896 312/18722 0.734812144753671 0.927795075126693 ATP2B1/ITGAV/TSPAN13/MCOLN3/PKD2/CALM2/ATP2A2/TRPM7/AFG3L2/FMR1/ANO6/AHNAK/TMEM165 13 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 3/896 79/18722 0.735692741671741 0.928661329651214 IGF1R/NEDD4/PLXNB1 3 GO:0007215 glutamate receptor signaling pathway 2/896 54/18722 0.737558200280027 0.929541406583117 APP/FMR1 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/896 54/18722 0.737558200280027 0.929541406583117 PKD2/CALM2 2 GO:0032330 regulation of chondrocyte differentiation 2/896 54/18722 0.737558200280027 0.929541406583117 EFEMP1/GLG1 2 GO:0060350 endochondral bone morphogenesis 2/896 54/18722 0.737558200280027 0.929541406583117 TRIP11/SERPINH1 2 GO:0070228 regulation of lymphocyte apoptotic process 2/896 54/18722 0.737558200280027 0.929541406583117 SLC39A10/AURKB 2 GO:2000300 regulation of synaptic vesicle exocytosis 2/896 54/18722 0.737558200280027 0.929541406583117 ATP2A2/FMR1 2 GO:0051051 negative regulation of transport 20/896 470/18722 0.737923458491305 0.929756292118631 HMGB1/ITGAV/LMAN1/BARD1/GJA1/ANK3/PKD2/TPR/GABRE/CALM2/FRMD4A/FERMT1/PPP1R9A/NEDD4/GOPC/FMR1/UBE2G2/LRPAP1/IDH2/ERP29 20 GO:0006874 cellular calcium ion homeostasis 19/896 448/18722 0.739003721094162 0.930871705673755 HMGB1/HSP90B1/ATP2B1/APP/ITGAV/MCOLN3/GJA1/PKD2/ATP13A3/CALM2/ATP2A2/CCDC47/AFG3L2/CALR/HEXB/LRP1/CD24/TMEM165/TGM2 19 GO:0045621 positive regulation of lymphocyte differentiation 4/896 104/18722 0.739394924256439 0.931118799366986 PRKDC/SOX4/CD46/XRCC6 4 GO:0098754 detoxification 6/896 152/18722 0.740603848879766 0.932145399073612 BMP7/DHFR/GPX8/MT2A/PRDX4/ADH5 6 GO:0007599 hemostasis 9/896 222/18722 0.740795903662607 0.932145399073612 F5/LMAN1/DGKD/FZD6/FBLN1/VCL/VKORC1/HPS5/ANO6 9 GO:0050817 coagulation 9/896 222/18722 0.740795903662607 0.932145399073612 F5/LMAN1/DGKD/FZD6/FBLN1/VCL/VKORC1/HPS5/ANO6 9 GO:0001894 tissue homeostasis 11/896 268/18722 0.741088005709921 0.932267230371321 EGFR/LAMC1/ITGB1/BARD1/GJA1/GCNT2/NF1/YAP1/VCL/SLC2A1/LSR 11 GO:0010634 positive regulation of epithelial cell migration 7/896 176/18722 0.743242246131996 0.932516237774538 HMGB1/MET/NRP2/NRP1/ROCK2/CALR/RTN4 7 GO:0043534 blood vessel endothelial cell migration 7/896 176/18722 0.743242246131996 0.932516237774538 HMGB1/ITGB1/NRP1/AMOT/EMP2/NF1/ID1 7 GO:0000041 transition metal ion transport 4/896 105/18722 0.746151480862531 0.932516237774538 SLC39A10/SLC39A1/TMEM165/CLTC 4 GO:0062207 regulation of pattern recognition receptor signaling pathway 4/896 105/18722 0.746151480862531 0.932516237774538 HMGB1/LGR4/PUM1/RTN4 4 GO:0002067 glandular epithelial cell differentiation 2/896 55/18722 0.746760242398206 0.932516237774538 CDK6/RHEB 2 GO:0010676 positive regulation of cellular carbohydrate metabolic process 2/896 55/18722 0.746760242398206 0.932516237774538 HMGB1/DDB1 2 GO:0043331 response to dsRNA 2/896 55/18722 0.746760242398206 0.932516237774538 COLEC12/DHX9 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/896 55/18722 0.746760242398206 0.932516237774538 ROCK2/RTN4 2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1/896 28/18722 0.74695058509632 0.932516237774538 CALR 1 GO:0002507 tolerance induction 1/896 28/18722 0.74695058509632 0.932516237774538 HMGB1 1 GO:0003156 regulation of animal organ formation 1/896 28/18722 0.74695058509632 0.932516237774538 BMP7 1 GO:0008299 isoprenoid biosynthetic process 1/896 28/18722 0.74695058509632 0.932516237774538 FDPS 1 GO:0009312 oligosaccharide biosynthetic process 1/896 28/18722 0.74695058509632 0.932516237774538 FUT8 1 GO:0010575 positive regulation of vascular endothelial growth factor production 1/896 28/18722 0.74695058509632 0.932516237774538 BRCA1 1 GO:0010884 positive regulation of lipid storage 1/896 28/18722 0.74695058509632 0.932516237774538 HILPDA 1 GO:0031342 negative regulation of cell killing 1/896 28/18722 0.74695058509632 0.932516237774538 HSP90AB1 1 GO:0038094 Fc-gamma receptor signaling pathway 1/896 28/18722 0.74695058509632 0.932516237774538 YES1 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/896 28/18722 0.74695058509632 0.932516237774538 CTNND1 1 GO:0045589 regulation of regulatory T cell differentiation 1/896 28/18722 0.74695058509632 0.932516237774538 CD46 1 GO:0045671 negative regulation of osteoclast differentiation 1/896 28/18722 0.74695058509632 0.932516237774538 FBN1 1 GO:0045686 negative regulation of glial cell differentiation 1/896 28/18722 0.74695058509632 0.932516237774538 NF1 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/896 28/18722 0.74695058509632 0.932516237774538 SUZ12 1 GO:0060765 regulation of androgen receptor signaling pathway 1/896 28/18722 0.74695058509632 0.932516237774538 SMARCA4 1 GO:0062125 regulation of mitochondrial gene expression 1/896 28/18722 0.74695058509632 0.932516237774538 LRPPRC 1 GO:0086011 membrane repolarization during action potential 1/896 28/18722 0.74695058509632 0.932516237774538 ATP1A1 1 GO:0090659 walking behavior 1/896 28/18722 0.74695058509632 0.932516237774538 OXR1 1 GO:1903649 regulation of cytoplasmic transport 1/896 28/18722 0.74695058509632 0.932516237774538 RDX 1 GO:1903671 negative regulation of sprouting angiogenesis 1/896 28/18722 0.74695058509632 0.932516237774538 SEMA6A 1 GO:1903672 positive regulation of sprouting angiogenesis 1/896 28/18722 0.74695058509632 0.932516237774538 HMGB1 1 GO:0000422 autophagy of mitochondrion 3/896 81/18722 0.751005335973536 0.936598608656651 FZD5/HUWE1/SLC25A5 3 GO:0001523 retinoid metabolic process 3/896 81/18722 0.751005335973536 0.936598608656651 LRP2/LRP1/ADH5 3 GO:0061726 mitochondrion disassembly 3/896 81/18722 0.751005335973536 0.936598608656651 FZD5/HUWE1/SLC25A5 3 GO:2000106 regulation of leukocyte apoptotic process 3/896 81/18722 0.751005335973536 0.936598608656651 SLC39A10/AURKB/CDKN2A 3 GO:0071887 leukocyte apoptotic process 4/896 106/18722 0.752773510071293 0.938313508376071 SLC39A10/AURKB/CDKN2A/CTSL 4 GO:1903707 negative regulation of hemopoiesis 4/896 106/18722 0.752773510071293 0.938313508376071 HMGB1/FBN1/CDK6/HSPA9 4 GO:0048015 phosphatidylinositol-mediated signaling 7/896 178/18722 0.753625634977734 0.939130457160977 EGFR/CEP55/IGF1R/NF1/NEDD4/PLXNB1/PLEKHA1 7 GO:0002711 positive regulation of T cell mediated immunity 2/896 56/18722 0.755683827295649 0.940019756099102 FZD5/HSPD1 2 GO:0043470 regulation of carbohydrate catabolic process 2/896 56/18722 0.755683827295649 0.940019756099102 HMGB1/APP 2 GO:0045599 negative regulation of fat cell differentiation 2/896 56/18722 0.755683827295649 0.940019756099102 YAP1/ASXL1 2 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 3/896 82/18722 0.758390576335215 0.940019756099102 HMGB2/BRCA1/CASP8AP2 3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 1/896 29/18722 0.759079197258174 0.940019756099102 YES1 1 GO:0003209 cardiac atrium morphogenesis 1/896 29/18722 0.759079197258174 0.940019756099102 SOX4 1 GO:0015701 bicarbonate transport 1/896 29/18722 0.759079197258174 0.940019756099102 SLC26A2 1 GO:0019359 nicotinamide nucleotide biosynthetic process 1/896 29/18722 0.759079197258174 0.940019756099102 IDH2 1 GO:0019363 pyridine nucleotide biosynthetic process 1/896 29/18722 0.759079197258174 0.940019756099102 IDH2 1 GO:0021772 olfactory bulb development 1/896 29/18722 0.759079197258174 0.940019756099102 KIF14 1 GO:0034067 protein localization to Golgi apparatus 1/896 29/18722 0.759079197258174 0.940019756099102 VPS13A 1 GO:0034311 diol metabolic process 1/896 29/18722 0.759079197258174 0.940019756099102 DHFR 1 GO:0048265 response to pain 1/896 29/18722 0.759079197258174 0.940019756099102 VWA1 1 GO:0048665 neuron fate specification 1/896 29/18722 0.759079197258174 0.940019756099102 ESRP1 1 GO:0051654 establishment of mitochondrion localization 1/896 29/18722 0.759079197258174 0.940019756099102 LRPPRC 1 GO:0095500 acetylcholine receptor signaling pathway 1/896 29/18722 0.759079197258174 0.940019756099102 LY6E 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/896 29/18722 0.759079197258174 0.940019756099102 ANK3 1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/896 29/18722 0.759079197258174 0.940019756099102 USP47 1 GO:1902430 negative regulation of amyloid-beta formation 1/896 29/18722 0.759079197258174 0.940019756099102 RTN4 1 GO:2000406 positive regulation of T cell migration 1/896 29/18722 0.759079197258174 0.940019756099102 APP 1 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/896 107/18722 0.759261872542551 0.940019756099102 RIF1/MSH2/FZD5/HSPD1 4 GO:0005976 polysaccharide metabolic process 4/896 107/18722 0.759261872542551 0.940019756099102 HMGB1/AGL/PHKB/CLTC 4 GO:0008637 apoptotic mitochondrial changes 4/896 107/18722 0.759261872542551 0.940019756099102 GGCT/GCLM/HSPD1/SLC25A5 4 GO:0071868 cellular response to monoamine stimulus 4/896 107/18722 0.759261872542551 0.940019756099102 APP/ID1/HDAC2/TGM2 4 GO:0071870 cellular response to catecholamine stimulus 4/896 107/18722 0.759261872542551 0.940019756099102 APP/ID1/HDAC2/TGM2 4 GO:0048193 Golgi vesicle transport 12/896 296/18722 0.762080287020275 0.94326452948789 LMAN1/SPTBN1/PGAP1/ANK3/VPS13A/GOLGA4/MACF1/GOPC/TRIP11/ERGIC2/TMED4/CNIH4 12 GO:0015698 inorganic anion transport 7/896 180/18722 0.763705436069311 0.944585267832329 RACGAP1/SLC20A1/GABRE/SLC26A2/ANKH/ANO6/CLDN4 7 GO:0006949 syncytium formation 2/896 57/18722 0.76433449720073 0.944585267832329 ERVH48-1/MYOF 2 GO:0034205 amyloid-beta formation 2/896 57/18722 0.76433449720073 0.944585267832329 ROCK2/RTN4 2 GO:0051289 protein homotetramerization 2/896 57/18722 0.76433449720073 0.944585267832329 TK1/PKD2 2 GO:0060760 positive regulation of response to cytokine stimulus 2/896 57/18722 0.76433449720073 0.944585267832329 DHX9/TRIM44 2 GO:0061756 leukocyte adhesion to vascular endothelial cell 2/896 57/18722 0.76433449720073 0.944585267832329 ITGB1/NFAT5 2 GO:0050672 negative regulation of lymphocyte proliferation 3/896 83/18722 0.765597792387587 0.945192147988026 PAWR/DLG1/DLG5 3 GO:0050886 endocrine process 3/896 83/18722 0.765597792387587 0.945192147988026 MME/ENPEP/GJA1 3 GO:0098659 inorganic cation import across plasma membrane 4/896 108/18722 0.765617519118077 0.945192147988026 SLC39A10/ATP1A1/DLG1/ATP1B3 4 GO:0099587 inorganic ion import across plasma membrane 4/896 108/18722 0.765617519118077 0.945192147988026 SLC39A10/ATP1A1/DLG1/ATP1B3 4 GO:0032640 tumor necrosis factor production 7/896 181/18722 0.768631838897651 0.945751619339026 HMGB1/APP/FZD5/DICER1/DHX9/HSPD1/HDAC2 7 GO:0032680 regulation of tumor necrosis factor production 7/896 181/18722 0.768631838897651 0.945751619339026 HMGB1/APP/FZD5/DICER1/DHX9/HSPD1/HDAC2 7 GO:0046328 regulation of JNK cascade 5/896 133/18722 0.768645348479034 0.945751619339026 HMGB1/EGFR/APP/MARVELD3/IGF1R 5 GO:0006884 cell volume homeostasis 1/896 30/18722 0.770627104991373 0.945751619339026 ANO6 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/896 30/18722 0.770627104991373 0.945751619339026 APP 1 GO:0007202 activation of phospholipase C activity 1/896 30/18722 0.770627104991373 0.945751619339026 EGFR 1 GO:0008209 androgen metabolic process 1/896 30/18722 0.770627104991373 0.945751619339026 PLEKHA1 1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/896 30/18722 0.770627104991373 0.945751619339026 CALM2 1 GO:0030204 chondroitin sulfate metabolic process 1/896 30/18722 0.770627104991373 0.945751619339026 CHPF 1 GO:0031365 N-terminal protein amino acid modification 1/896 30/18722 0.770627104991373 0.945751619339026 SOX4 1 GO:0034694 response to prostaglandin 1/896 30/18722 0.770627104991373 0.945751619339026 TGFBR3 1 GO:0036296 response to increased oxygen levels 1/896 30/18722 0.770627104991373 0.945751619339026 HDAC2 1 GO:0043032 positive regulation of macrophage activation 1/896 30/18722 0.770627104991373 0.945751619339026 HSPD1 1 GO:0045939 negative regulation of steroid metabolic process 1/896 30/18722 0.770627104991373 0.945751619339026 ATP1A1 1 GO:0048799 animal organ maturation 1/896 30/18722 0.770627104991373 0.945751619339026 PLXNB1 1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 1/896 30/18722 0.770627104991373 0.945751619339026 PAWR 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/896 30/18722 0.770627104991373 0.945751619339026 EGFR 1 GO:0060603 mammary gland duct morphogenesis 1/896 30/18722 0.770627104991373 0.945751619339026 LRP5 1 GO:0070168 negative regulation of biomineral tissue development 1/896 30/18722 0.770627104991373 0.945751619339026 ROCK2 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/896 30/18722 0.770627104991373 0.945751619339026 HSP90AA1 1 GO:0099068 postsynapse assembly 1/896 30/18722 0.770627104991373 0.945751619339026 ZDHHC12 1 GO:1903019 negative regulation of glycoprotein metabolic process 1/896 30/18722 0.770627104991373 0.945751619339026 AGO2 1 GO:1903579 negative regulation of ATP metabolic process 1/896 30/18722 0.770627104991373 0.945751619339026 PARP1 1 GO:0006821 chloride transport 4/896 109/18722 0.771841485211206 0.945885965278526 GABRE/SLC26A2/ANO6/CLDN4 4 GO:0010660 regulation of muscle cell apoptotic process 3/896 84/18722 0.772629138617964 0.945885965278526 BMP7/CDKN2A/DNMT1 3 GO:0032945 negative regulation of mononuclear cell proliferation 3/896 84/18722 0.772629138617964 0.945885965278526 PAWR/DLG1/DLG5 3 GO:0042440 pigment metabolic process 3/896 84/18722 0.772629138617964 0.945885965278526 GMPS/PPAT/PAICS 3 GO:0098586 cellular response to virus 3/896 84/18722 0.772629138617964 0.945885965278526 HSP90AA1/PUM1/FMR1 3 GO:0034340 response to type I interferon 2/896 58/18722 0.772717902091799 0.945885965278526 SETD2/HSP90AB1 2 GO:0042743 hydrogen peroxide metabolic process 2/896 58/18722 0.772717902091799 0.945885965278526 EGFR/PRDX4 2 GO:0043525 positive regulation of neuron apoptotic process 2/896 58/18722 0.772717902091799 0.945885965278526 MYBL2/NF1 2 GO:0097035 regulation of membrane lipid distribution 2/896 58/18722 0.772717902091799 0.945885965278526 TMEM30B/ANO6 2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 2/896 58/18722 0.772717902091799 0.945885965278526 SFPQ/BCLAF1 2 GO:0048017 inositol lipid-mediated signaling 7/896 182/18722 0.773482838197544 0.946579612805711 EGFR/CEP55/IGF1R/NF1/NEDD4/PLXNB1/PLEKHA1 7 GO:0002705 positive regulation of leukocyte mediated immunity 5/896 134/18722 0.774248634571871 0.947036357753432 CADM1/RIF1/MSH2/FZD5/HSPD1 5 GO:0044782 cilium organization 15/896 368/18722 0.7742528077737 0.947036357753432 GALNT11/LAMA5/CEP78/CENPJ/RAB3IP/PKD2/CCP110/CEP135/YAP1/PCM1/DYNLL2/AHI1/ATMIN/ASAP1/HSPB11 15 GO:0008654 phospholipid biosynthetic process 10/896 253/18722 0.775188127697691 0.947937531154912 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/SLC44A1/FDPS/HEXB/ISYNA1 10 GO:0009063 cellular amino acid catabolic process 4/896 110/18722 0.777934885361569 0.94948188814466 GLDC/ARHGAP11B/ENOSF1/PPAT 4 GO:0002709 regulation of T cell mediated immunity 3/896 85/18722 0.779486872269954 0.94948188814466 HMGB1/FZD5/HSPD1 3 GO:0009142 nucleoside triphosphate biosynthetic process 3/896 85/18722 0.779486872269954 0.94948188814466 TYMS/PARP1/DTYMK 3 GO:0097006 regulation of plasma lipoprotein particle levels 3/896 85/18722 0.779486872269954 0.94948188814466 VLDLR/KHSRP/LRPAP1 3 GO:0097194 execution phase of apoptosis 3/896 85/18722 0.779486872269954 0.94948188814466 TOP2A/DICER1/STK24 3 GO:0032768 regulation of monooxygenase activity 2/896 59/18722 0.780839776725234 0.94948188814466 EGFR/DHFR 2 GO:0043407 negative regulation of MAP kinase activity 2/896 59/18722 0.780839776725234 0.94948188814466 BMP7/NF1 2 GO:0048010 vascular endothelial growth factor receptor signaling pathway 2/896 59/18722 0.780839776725234 0.94948188814466 NRP1/NEDD4 2 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 2/896 59/18722 0.780839776725234 0.94948188814466 SUZ12/NCAPG2 2 GO:0002063 chondrocyte development 1/896 31/18722 0.781622082197008 0.94948188814466 SERPINH1 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/896 31/18722 0.781622082197008 0.94948188814466 CADM1 1 GO:0008045 motor neuron axon guidance 1/896 31/18722 0.781622082197008 0.94948188814466 NRP1 1 GO:0021988 olfactory lobe development 1/896 31/18722 0.781622082197008 0.94948188814466 KIF14 1 GO:0030149 sphingolipid catabolic process 1/896 31/18722 0.781622082197008 0.94948188814466 HEXB 1 GO:0031063 regulation of histone deacetylation 1/896 31/18722 0.781622082197008 0.94948188814466 NCAPG2 1 GO:0034472 snRNA 3'-end processing 1/896 31/18722 0.781622082197008 0.94948188814466 EXOSC8 1 GO:0042133 neurotransmitter metabolic process 1/896 31/18722 0.781622082197008 0.94948188814466 SLC6A4 1 GO:0045066 regulatory T cell differentiation 1/896 31/18722 0.781622082197008 0.94948188814466 CD46 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/896 31/18722 0.781622082197008 0.94948188814466 GJA1 1 GO:0060055 angiogenesis involved in wound healing 1/896 31/18722 0.781622082197008 0.94948188814466 DAG1 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/896 31/18722 0.781622082197008 0.94948188814466 NCAPG2 1 GO:0061117 negative regulation of heart growth 1/896 31/18722 0.781622082197008 0.94948188814466 GJA1 1 GO:0070633 transepithelial transport 1/896 31/18722 0.781622082197008 0.94948188814466 AHCYL1 1 GO:0070723 response to cholesterol 1/896 31/18722 0.781622082197008 0.94948188814466 DAG1 1 GO:0110150 negative regulation of biomineralization 1/896 31/18722 0.781622082197008 0.94948188814466 ROCK2 1 GO:2000144 positive regulation of DNA-templated transcription, initiation 1/896 31/18722 0.781622082197008 0.94948188814466 BCLAF1 1 GO:0006836 neurotransmitter transport 8/896 208/18722 0.783752298596062 0.951279457697884 SLC29A1/ITGB1/SLC38A1/SLC6A4/ATP2A2/PPP1R9A/SLC38A2/FMR1 8 GO:0001938 positive regulation of endothelial cell proliferation 4/896 111/18722 0.783898907956321 0.951279457697884 HMGB2/HMGB1/NRP2/NRP1 4 GO:0071867 response to monoamine 4/896 111/18722 0.783898907956321 0.951279457697884 APP/ID1/HDAC2/TGM2 4 GO:0071869 response to catecholamine 4/896 111/18722 0.783898907956321 0.951279457697884 APP/ID1/HDAC2/TGM2 4 GO:0022406 membrane docking 3/896 86/18722 0.7861733433482 0.95355476146959 RAB3IP/ATP2A2/AHCYL1 3 GO:0046928 regulation of neurotransmitter secretion 3/896 86/18722 0.7861733433482 0.95355476146959 ATP2A2/PPP1R9A/FMR1 3 GO:1903670 regulation of sprouting angiogenesis 2/896 60/18722 0.788705919611054 0.95520775005302 HMGB1/SEMA6A 2 GO:0002821 positive regulation of adaptive immune response 4/896 112/18722 0.789734810118703 0.95520775005302 RIF1/MSH2/FZD5/HSPD1 4 GO:0035601 protein deacylation 4/896 112/18722 0.789734810118703 0.95520775005302 NCAPG2/SFPQ/TBL1X/HDAC2 4 GO:0060078 regulation of postsynaptic membrane potential 5/896 137/18722 0.790434689821964 0.95520775005302 APP/SLC29A1/ADRB1/GABRE/PPP1R9A 5 GO:0002449 lymphocyte mediated immunity 14/896 350/18722 0.791068575861393 0.95520775005302 TUBB/HMGB1/TUBB4B/CADM1/RIF1/MSH6/MSH2/EMP2/RNF168/FZD5/CD46/UNG/HSPD1/KIF5B 14 GO:0003180 aortic valve morphogenesis 1/896 32/18722 0.792090575822361 0.95520775005302 ROCK2 1 GO:0006308 DNA catabolic process 1/896 32/18722 0.792090575822361 0.95520775005302 DICER1 1 GO:0010743 regulation of macrophage derived foam cell differentiation 1/896 32/18722 0.792090575822361 0.95520775005302 ITGAV 1 GO:0032196 transposition 1/896 32/18722 0.792090575822361 0.95520775005302 L1TD1 1 GO:0035456 response to interferon-beta 1/896 32/18722 0.792090575822361 0.95520775005302 UBE2G2 1 GO:0042044 fluid transport 1/896 32/18722 0.792090575822361 0.95520775005302 AHCYL1 1 GO:0042744 hydrogen peroxide catabolic process 1/896 32/18722 0.792090575822361 0.95520775005302 PRDX4 1 GO:0045684 positive regulation of epidermis development 1/896 32/18722 0.792090575822361 0.95520775005302 NCOA3 1 GO:0061037 negative regulation of cartilage development 1/896 32/18722 0.792090575822361 0.95520775005302 EFEMP1 1 GO:0071875 adrenergic receptor signaling pathway 1/896 32/18722 0.792090575822361 0.95520775005302 ADRB1 1 GO:0072525 pyridine-containing compound biosynthetic process 1/896 32/18722 0.792090575822361 0.95520775005302 IDH2 1 GO:0090022 regulation of neutrophil chemotaxis 1/896 32/18722 0.792090575822361 0.95520775005302 DPP4 1 GO:0090140 regulation of mitochondrial fission 1/896 32/18722 0.792090575822361 0.95520775005302 AURKA 1 GO:0097345 mitochondrial outer membrane permeabilization 1/896 32/18722 0.792090575822361 0.95520775005302 SLC25A5 1 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/896 32/18722 0.792090575822361 0.95520775005302 ERP29 1 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 1/896 32/18722 0.792090575822361 0.95520775005302 HMGB1 1 GO:0071706 tumor necrosis factor superfamily cytokine production 7/896 186/18722 0.792138140439863 0.95520775005302 HMGB1/APP/FZD5/DICER1/DHX9/HSPD1/HDAC2 7 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 7/896 186/18722 0.792138140439863 0.95520775005302 HMGB1/APP/FZD5/DICER1/DHX9/HSPD1/HDAC2 7 GO:1901606 alpha-amino acid catabolic process 3/896 87/18722 0.792690985115129 0.95563302094435 GLDC/ARHGAP11B/PPAT 3 GO:0042255 ribosome assembly 2/896 61/18722 0.796322173802674 0.959526011543151 PRKDC/XRCC5 2 GO:0043954 cellular component maintenance 2/896 61/18722 0.796322173802674 0.959526011543151 IGF1R/DLG1 2 GO:0030100 regulation of endocytosis 8/896 211/18722 0.796631825770254 0.959656910478727 ITGAV/DGKD/AHI1/FMR1/CD2AP/ANO6/LRP1/LRPAP1 8 GO:0061025 membrane fusion 6/896 163/18722 0.797775086346773 0.96079169077182 HUWE1/EEA1/KIF5B/SPESP1/MYOF/CTSL 6 GO:0009144 purine nucleoside triphosphate metabolic process 3/896 88/18722 0.79904230506646 0.961583071350748 PARP1/NUDT15/RAN 3 GO:0001906 cell killing 7/896 188/18722 0.801021230059453 0.961583071350748 TUBB/HMGN2/TUBB4B/CADM1/EMP2/KIF5B/HSP90AB1 7 GO:0007041 lysosomal transport 4/896 114/18722 0.801027595824519 0.961583071350748 HMGXB4/NEDD4/LRP1/HSPA8 4 GO:1904892 regulation of receptor signaling pathway via STAT 4/896 114/18722 0.801027595824519 0.961583071350748 SUZ12/CENPJ/PRLR/OCIAD1 4 GO:0070371 ERK1 and ERK2 cascade 13/896 330/18722 0.801640075581979 0.961583071350748 HMGB1/CDK1/EGFR/APP/ITGAV/NRP1/TPBG/SEMA6A/DLG1/GCNT2/EIF3A/FBLN1/LRP1 13 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/896 33/18722 0.802057769191177 0.961583071350748 YES1 1 GO:0006536 glutamate metabolic process 1/896 33/18722 0.802057769191177 0.961583071350748 GCLM 1 GO:0006654 phosphatidic acid biosynthetic process 1/896 33/18722 0.802057769191177 0.961583071350748 DGKD 1 GO:0010737 protein kinase A signaling 1/896 33/18722 0.802057769191177 0.961583071350748 RDX 1 GO:0018345 protein palmitoylation 1/896 33/18722 0.802057769191177 0.961583071350748 ZDHHC12 1 GO:0019362 pyridine nucleotide metabolic process 1/896 33/18722 0.802057769191177 0.961583071350748 IDH2 1 GO:0021696 cerebellar cortex morphogenesis 1/896 33/18722 0.802057769191177 0.961583071350748 KIF14 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/896 33/18722 0.802057769191177 0.961583071350748 NEDD4 1 GO:0045920 negative regulation of exocytosis 1/896 33/18722 0.802057769191177 0.961583071350748 FMR1 1 GO:0046496 nicotinamide nucleotide metabolic process 1/896 33/18722 0.802057769191177 0.961583071350748 IDH2 1 GO:0050901 leukocyte tethering or rolling 1/896 33/18722 0.802057769191177 0.961583071350748 ITGB1 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/896 33/18722 0.802057769191177 0.961583071350748 ANK3 1 GO:1902992 negative regulation of amyloid precursor protein catabolic process 1/896 33/18722 0.802057769191177 0.961583071350748 RTN4 1 GO:0007588 excretion 2/896 62/18722 0.803694409375591 0.962336872425149 NFAT5/SNX5 2 GO:0010573 vascular endothelial growth factor production 2/896 62/18722 0.803694409375591 0.962336872425149 ADGRG1/BRCA1 2 GO:0032615 interleukin-12 production 2/896 62/18722 0.803694409375591 0.962336872425149 HMGB1/HSPD1 2 GO:0032655 regulation of interleukin-12 production 2/896 62/18722 0.803694409375591 0.962336872425149 HMGB1/HSPD1 2 GO:0048663 neuron fate commitment 2/896 62/18722 0.803694409375591 0.962336872425149 ESRP1/RBPJ 2 GO:0022409 positive regulation of cell-cell adhesion 11/896 284/18722 0.804195971031731 0.962338116130093 HMGB1/BMP7/DPP4/ANK3/SOX4/GCNT2/CD46/NFAT5/YES1/HSPD1/CD24 11 GO:0010657 muscle cell apoptotic process 3/896 89/18722 0.805229876371838 0.962338116130093 BMP7/CDKN2A/DNMT1 3 GO:0071675 regulation of mononuclear cell migration 4/896 115/18722 0.806487293637777 0.962338116130093 HMGB1/APP/CALR/ANO6 4 GO:0022407 regulation of cell-cell adhesion 18/896 448/18722 0.809579921220963 0.962338116130093 HMGB1/CDH1/TENM3/BMP7/DPP4/PAWR/ANK3/SOX4/DLG1/GCNT2/CD46/NFAT5/RDX/DLG5/SPINT2/YES1/HSPD1/CD24 18 GO:0016241 regulation of macroautophagy 5/896 141/18722 0.810590028923485 0.962338116130093 SNX5/NEDD4/LARP1/RHEB/SLC25A5 5 GO:0048284 organelle fusion 5/896 141/18722 0.810590028923485 0.962338116130093 CDK1/AFG3L2/HUWE1/EEA1/KIF5B 5 GO:0001947 heart looping 2/896 63/18722 0.810828507477679 0.962338116130093 PKD2/AHI1 2 GO:0016239 positive regulation of macroautophagy 2/896 63/18722 0.810828507477679 0.962338116130093 LARP1/SLC25A5 2 GO:0030239 myofibril assembly 2/896 63/18722 0.810828507477679 0.962338116130093 ITGB1/CSRP2 2 GO:0046902 regulation of mitochondrial membrane permeability 2/896 63/18722 0.810828507477679 0.962338116130093 ARHGAP11B/SLC25A5 2 GO:0050854 regulation of antigen receptor-mediated signaling pathway 2/896 63/18722 0.810828507477679 0.962338116130093 SLC39A10/PAWR 2 GO:0099601 regulation of neurotransmitter receptor activity 2/896 63/18722 0.810828507477679 0.962338116130093 APP/AKAP9 2 GO:0035278 miRNA mediated inhibition of translation 3/896 90/18722 0.811256329766666 0.962338116130093 AGO2/TNRC6A/EIF4G1 3 GO:0040033 negative regulation of translation, ncRNA-mediated 3/896 90/18722 0.811256329766666 0.962338116130093 AGO2/TNRC6A/EIF4G1 3 GO:0061097 regulation of protein tyrosine kinase activity 3/896 90/18722 0.811256329766666 0.962338116130093 APP/NCAPG2/CD24 3 GO:0070664 negative regulation of leukocyte proliferation 3/896 90/18722 0.811256329766666 0.962338116130093 PAWR/DLG1/DLG5 3 GO:0097581 lamellipodium organization 3/896 90/18722 0.811256329766666 0.962338116130093 ITGB1/KANK1/VCL 3 GO:0099175 regulation of postsynapse organization 3/896 90/18722 0.811256329766666 0.962338116130093 NRP2/PPP1R9A/HSPA8 3 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 3/896 90/18722 0.811256329766666 0.962338116130093 GJA1/ADAMTS1/DNMT1 3 GO:0010661 positive regulation of muscle cell apoptotic process 1/896 34/18722 0.811547642314656 0.962338116130093 CDKN2A 1 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/896 34/18722 0.811547642314656 0.962338116130093 CALM2 1 GO:0030851 granulocyte differentiation 1/896 34/18722 0.811547642314656 0.962338116130093 LBR 1 GO:0031128 developmental induction 1/896 34/18722 0.811547642314656 0.962338116130093 FZD5 1 GO:0032743 positive regulation of interleukin-2 production 1/896 34/18722 0.811547642314656 0.962338116130093 SPTBN1 1 GO:0032770 positive regulation of monooxygenase activity 1/896 34/18722 0.811547642314656 0.962338116130093 DHFR 1 GO:0034383 low-density lipoprotein particle clearance 1/896 34/18722 0.811547642314656 0.962338116130093 KHSRP 1 GO:0035590 purinergic nucleotide receptor signaling pathway 1/896 34/18722 0.811547642314656 0.962338116130093 ANO6 1 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1/896 34/18722 0.811547642314656 0.962338116130093 PUM1 1 GO:0044319 wound healing, spreading of cells 1/896 34/18722 0.811547642314656 0.962338116130093 FERMT1 1 GO:0048741 skeletal muscle fiber development 1/896 34/18722 0.811547642314656 0.962338116130093 FBXO22 1 GO:0050869 negative regulation of B cell activation 1/896 34/18722 0.811547642314656 0.962338116130093 PAWR 1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 1/896 34/18722 0.811547642314656 0.962338116130093 TGM2 1 GO:0055094 response to lipoprotein particle 1/896 34/18722 0.811547642314656 0.962338116130093 ITGB1 1 GO:0070050 neuron cellular homeostasis 1/896 34/18722 0.811547642314656 0.962338116130093 ATP2B1 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/896 34/18722 0.811547642314656 0.962338116130093 NFAT5 1 GO:0090505 epiboly involved in wound healing 1/896 34/18722 0.811547642314656 0.962338116130093 FERMT1 1 GO:0098751 bone cell development 1/896 34/18722 0.811547642314656 0.962338116130093 FBN1 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/896 34/18722 0.811547642314656 0.962338116130093 SUZ12 1 GO:0060538 skeletal muscle organ development 6/896 166/18722 0.81155702881017 0.962338116130093 DAG1/NR2F2/SVIL/KLF5/FBXO22/DDX17 6 GO:0098732 macromolecule deacylation 4/896 116/18722 0.811824490505707 0.962416219934007 NCAPG2/SFPQ/TBL1X/HDAC2 4 GO:0051403 stress-activated MAPK cascade 9/896 239/18722 0.812900564745112 0.962758265423185 HMGB1/EGFR/HACD3/APP/PBK/MARVELD3/IGF1R/FOXM1/DLG1 9 GO:0042113 B cell activation 13/896 334/18722 0.814691890089768 0.962758265423185 PRKDC/EZH2/RIF1/SLC39A10/ITGB1/MSH6/PAWR/MSH2/RNF168/UNG/HSPD1/RBPJ/SLC25A5 13 GO:0050729 positive regulation of inflammatory response 5/896 142/18722 0.815380150788575 0.962758265423185 EGFR/APP/DHX9/HSPD1/TGM2 5 GO:0007254 JNK cascade 6/896 167/18722 0.815984174986348 0.962758265423185 HMGB1/EGFR/HACD3/APP/MARVELD3/IGF1R 6 GO:0055088 lipid homeostasis 6/896 167/18722 0.815984174986348 0.962758265423185 TMEM97/LRP5/LIMA1/CD24/ORMDL1/RTN4 6 GO:0014902 myotube differentiation 4/896 117/18722 0.817040716414824 0.962758265423185 MYEF2/KLF5/FBXO22/MYOF 4 GO:0042147 retrograde transport, endosome to Golgi 3/896 91/18722 0.817124345881035 0.962758265423185 SNX5/RHOBTB3/CLTC 3 GO:0045974 regulation of translation, ncRNA-mediated 3/896 91/18722 0.817124345881035 0.962758265423185 AGO2/TNRC6A/EIF4G1 3 GO:1990874 vascular associated smooth muscle cell proliferation 3/896 91/18722 0.817124345881035 0.962758265423185 GJA1/ADAMTS1/DNMT1 3 GO:0030888 regulation of B cell proliferation 2/896 64/18722 0.817730345841045 0.962758265423185 SLC39A10/PAWR 2 GO:0046530 photoreceptor cell differentiation 2/896 64/18722 0.817730345841045 0.962758265423185 AHI1/TUG1 2 GO:0046579 positive regulation of Ras protein signal transduction 2/896 64/18722 0.817730345841045 0.962758265423185 ADGRG1/NET1 2 GO:0055002 striated muscle cell development 2/896 64/18722 0.817730345841045 0.962758265423185 ITGB1/CSRP2 2 GO:1903409 reactive oxygen species biosynthetic process 2/896 64/18722 0.817730345841045 0.962758265423185 SLC5A3/HSPD1 2 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/896 168/18722 0.820329057139428 0.962758265423185 HMGB1/RIF1/MSH2/FZD5/CD46/HSPD1 6 GO:0001569 branching involved in blood vessel morphogenesis 1/896 35/18722 0.820583029326967 0.962758265423185 NRP1 1 GO:0003298 physiological muscle hypertrophy 1/896 35/18722 0.820583029326967 0.962758265423185 PARP2 1 GO:0003301 physiological cardiac muscle hypertrophy 1/896 35/18722 0.820583029326967 0.962758265423185 PARP2 1 GO:0006084 acetyl-CoA metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 ACSS1 1 GO:0006739 NADP metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 IDH2 1 GO:0009119 ribonucleoside metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 MTAP 1 GO:0010664 negative regulation of striated muscle cell apoptotic process 1/896 35/18722 0.820583029326967 0.962758265423185 BMP7 1 GO:0010837 regulation of keratinocyte proliferation 1/896 35/18722 0.820583029326967 0.962758265423185 YAP1 1 GO:0019068 virion assembly 1/896 35/18722 0.820583029326967 0.962758265423185 NEDD4 1 GO:0032350 regulation of hormone metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 ATP1A1 1 GO:0034331 cell junction maintenance 1/896 35/18722 0.820583029326967 0.962758265423185 DLG1 1 GO:0042462 eye photoreceptor cell development 1/896 35/18722 0.820583029326967 0.962758265423185 TUG1 1 GO:0043243 positive regulation of protein-containing complex disassembly 1/896 35/18722 0.820583029326967 0.962758265423185 IGF1R 1 GO:0044273 sulfur compound catabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 GLB1 1 GO:0045454 cell redox homeostasis 1/896 35/18722 0.820583029326967 0.962758265423185 PRDX4 1 GO:0045880 positive regulation of smoothened signaling pathway 1/896 35/18722 0.820583029326967 0.962758265423185 DLG5 1 GO:0045922 negative regulation of fatty acid metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 BRCA1 1 GO:0046471 phosphatidylglycerol metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 HADHA 1 GO:0046627 negative regulation of insulin receptor signaling pathway 1/896 35/18722 0.820583029326967 0.962758265423185 KANK1 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/896 35/18722 0.820583029326967 0.962758265423185 CHPF 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/896 35/18722 0.820583029326967 0.962758265423185 PARP2 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/896 35/18722 0.820583029326967 0.962758265423185 NRP1 1 GO:0090504 epiboly 1/896 35/18722 0.820583029326967 0.962758265423185 FERMT1 1 GO:0106056 regulation of calcineurin-mediated signaling 1/896 35/18722 0.820583029326967 0.962758265423185 NFAT5 1 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1/896 35/18722 0.820583029326967 0.962758265423185 CALM2 1 GO:1905207 regulation of cardiocyte differentiation 1/896 35/18722 0.820583029326967 0.962758265423185 EGFR 1 GO:2000403 positive regulation of lymphocyte migration 1/896 35/18722 0.820583029326967 0.962758265423185 APP 1 GO:0007613 memory 4/896 118/18722 0.822137542920997 0.964108236282201 FEN1/SLC6A4/VLDLR/SERPINF1 4 GO:0071346 cellular response to interferon-gamma 4/896 118/18722 0.822137542920997 0.964108236282201 MYO1C/SYNCRIP/KIF5B/HSP90AB1 4 GO:0070509 calcium ion import 3/896 92/18722 0.822836647991471 0.964454249327593 PKD2/ATP2A2/AFG3L2 3 GO:1903351 cellular response to dopamine 3/896 92/18722 0.822836647991471 0.964454249327593 ID1/HDAC2/TGM2 3 GO:0015909 long-chain fatty acid transport 2/896 65/18722 0.824405785652351 0.965345406108492 SLC27A2/SLC2A1 2 GO:0045453 bone resorption 2/896 65/18722 0.824405785652351 0.965345406108492 EGFR/NF1 2 GO:0046513 ceramide biosynthetic process 2/896 65/18722 0.824405785652351 0.965345406108492 DEGS1/ORMDL1 2 GO:0070613 regulation of protein processing 2/896 65/18722 0.824405785652351 0.965345406108492 BCL2L12/GLG1 2 GO:0060249 anatomical structure homeostasis 12/896 314/18722 0.825756688801433 0.965966911608565 EGFR/ATP2B1/LAMC1/ITGB1/BARD1/GJA1/GCNT2/NF1/YAP1/VCL/SLC2A1/LSR 12 GO:0032088 negative regulation of NF-kappaB transcription factor activity 3/896 93/18722 0.8283959951812 0.965966911608565 BMP7/CDKN2A/UFL1 3 GO:0106027 neuron projection organization 3/896 93/18722 0.8283959951812 0.965966911608565 APP/IGF1R/PPP1R9A 3 GO:1903350 response to dopamine 3/896 93/18722 0.8283959951812 0.965966911608565 ID1/HDAC2/TGM2 3 GO:0007259 receptor signaling pathway via JAK-STAT 6/896 170/18722 0.828774990085835 0.965966911608565 SUZ12/CENPJ/PKD2/PRLR/HDAC2/OCIAD1 6 GO:0006699 bile acid biosynthetic process 1/896 36/18722 0.829185673182216 0.965966911608565 SLC27A2 1 GO:0010762 regulation of fibroblast migration 1/896 36/18722 0.829185673182216 0.965966911608565 ITGB1 1 GO:0016180 snRNA processing 1/896 36/18722 0.829185673182216 0.965966911608565 EXOSC8 1 GO:0030224 monocyte differentiation 1/896 36/18722 0.829185673182216 0.965966911608565 CDK6 1 GO:0036314 response to sterol 1/896 36/18722 0.829185673182216 0.965966911608565 DAG1 1 GO:0044060 regulation of endocrine process 1/896 36/18722 0.829185673182216 0.965966911608565 GJA1 1 GO:0044743 protein transmembrane import into intracellular organelle 1/896 36/18722 0.829185673182216 0.965966911608565 HSPD1 1 GO:0045652 regulation of megakaryocyte differentiation 1/896 36/18722 0.829185673182216 0.965966911608565 HMGB2 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/896 36/18722 0.829185673182216 0.965966911608565 DGKD 1 GO:0045746 negative regulation of Notch signaling pathway 1/896 36/18722 0.829185673182216 0.965966911608565 BMP7 1 GO:0046466 membrane lipid catabolic process 1/896 36/18722 0.829185673182216 0.965966911608565 HEXB 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/896 36/18722 0.829185673182216 0.965966911608565 HSP90AB1 1 GO:0070873 regulation of glycogen metabolic process 1/896 36/18722 0.829185673182216 0.965966911608565 HMGB1 1 GO:0071402 cellular response to lipoprotein particle stimulus 1/896 36/18722 0.829185673182216 0.965966911608565 ITGB1 1 GO:0097009 energy homeostasis 1/896 36/18722 0.829185673182216 0.965966911608565 EIF4G1 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/896 36/18722 0.829185673182216 0.965966911608565 USP47 1 GO:1905953 negative regulation of lipid localization 2/896 66/18722 0.830860659684997 0.9676820661957 ITGAV/ASXL1 2 GO:0042129 regulation of T cell proliferation 6/896 171/18722 0.83287758356596 0.968419173921171 HMGB1/PAWR/DLG1/CD46/DLG5/CD24 6 GO:0051048 negative regulation of secretion 6/896 171/18722 0.83287758356596 0.968419173921171 GJA1/FRMD4A/PPP1R9A/FMR1/IDH2/ERP29 6 GO:0022408 negative regulation of cell-cell adhesion 7/896 196/18722 0.833671988337659 0.968419173921171 HMGB1/CDH1/PAWR/DLG1/RDX/DLG5/SPINT2 7 GO:0002690 positive regulation of leukocyte chemotaxis 3/896 94/18722 0.833805175894599 0.968419173921171 HMGB1/CALR/ANO6 3 GO:0010506 regulation of autophagy 12/896 317/18722 0.835002044479041 0.968419173921171 HMGB1/MET/SOGA1/FZD5/SNX5/NEDD4/USP10/LARP1/EIF4G1/UFL1/RHEB/SLC25A5 12 GO:0002221 pattern recognition receptor signaling pathway 6/896 172/18722 0.836900995251744 0.968419173921171 HMGB1/COLEC12/LGR4/HSPD1/PUM1/RTN4 6 GO:0010517 regulation of phospholipase activity 2/896 67/18722 0.837100761602697 0.968419173921171 EGFR/LRP1 2 GO:0032890 regulation of organic acid transport 2/896 67/18722 0.837100761602697 0.968419173921171 ITGB1/ARL6IP1 2 GO:0035914 skeletal muscle cell differentiation 2/896 67/18722 0.837100761602697 0.968419173921171 KLF5/DDX17 2 GO:0061371 determination of heart left/right asymmetry 2/896 67/18722 0.837100761602697 0.968419173921171 PKD2/AHI1 2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/896 37/18722 0.837376277743317 0.968419173921171 RPS21 1 GO:0002369 T cell cytokine production 1/896 37/18722 0.837376277743317 0.968419173921171 FZD5 1 GO:0002724 regulation of T cell cytokine production 1/896 37/18722 0.837376277743317 0.968419173921171 FZD5 1 GO:0003016 respiratory system process 1/896 37/18722 0.837376277743317 0.968419173921171 ADH5 1 GO:0007340 acrosome reaction 1/896 37/18722 0.837376277743317 0.968419173921171 SPESP1 1 GO:0014904 myotube cell development 1/896 37/18722 0.837376277743317 0.968419173921171 FBXO22 1 GO:0016202 regulation of striated muscle tissue development 1/896 37/18722 0.837376277743317 0.968419173921171 CENPF 1 GO:0030513 positive regulation of BMP signaling pathway 1/896 37/18722 0.837376277743317 0.968419173921171 RBPJ 1 GO:0032885 regulation of polysaccharide biosynthetic process 1/896 37/18722 0.837376277743317 0.968419173921171 CLTC 1 GO:0042178 xenobiotic catabolic process 1/896 37/18722 0.837376277743317 0.968419173921171 NUDT15 1 GO:0043029 T cell homeostasis 1/896 37/18722 0.837376277743317 0.968419173921171 CCNB2 1 GO:0043368 positive T cell selection 1/896 37/18722 0.837376277743317 0.968419173921171 CTSL 1 GO:0045730 respiratory burst 1/896 37/18722 0.837376277743317 0.968419173921171 CD24 1 GO:0046473 phosphatidic acid metabolic process 1/896 37/18722 0.837376277743317 0.968419173921171 DGKD 1 GO:0060416 response to growth hormone 1/896 37/18722 0.837376277743317 0.968419173921171 CACYBP 1 GO:0071542 dopaminergic neuron differentiation 1/896 37/18722 0.837376277743317 0.968419173921171 RYK 1 GO:0071985 multivesicular body sorting pathway 1/896 37/18722 0.837376277743317 0.968419173921171 EXPH5 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/896 37/18722 0.837376277743317 0.968419173921171 EZH2 1 GO:1900077 negative regulation of cellular response to insulin stimulus 1/896 37/18722 0.837376277743317 0.968419173921171 KANK1 1 GO:0046879 hormone secretion 11/896 295/18722 0.840523757240984 0.971086242350296 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/FAM3B 11 GO:0031098 stress-activated protein kinase signaling cascade 9/896 247/18722 0.8411015020278 0.971086242350296 HMGB1/EGFR/HACD3/APP/PBK/MARVELD3/IGF1R/FOXM1/DLG1 9 GO:0002688 regulation of leukocyte chemotaxis 4/896 122/18722 0.841363523954127 0.971086242350296 HMGB1/DPP4/CALR/ANO6 4 GO:0050868 negative regulation of T cell activation 4/896 122/18722 0.841363523954127 0.971086242350296 HMGB1/PAWR/DLG1/DLG5 4 GO:0072329 monocarboxylic acid catabolic process 4/896 122/18722 0.841363523954127 0.971086242350296 SLC27A2/ACAT2/ECHDC2/HADHA 4 GO:0050905 neuromuscular process 5/896 148/18722 0.8421103643198 0.971086242350296 APP/IGDCC3/ATP2A2/HEXB/TMEM150C 5 GO:0009247 glycolipid biosynthetic process 2/896 68/18722 0.843131836349688 0.971086242350296 PGAP1/GPAA1 2 GO:0051148 negative regulation of muscle cell differentiation 2/896 68/18722 0.843131836349688 0.971086242350296 EZH2/DNMT1 2 GO:0006637 acyl-CoA metabolic process 3/896 96/18722 0.844184302447603 0.971086242350296 SLC25A1/ACSS1/TECR 3 GO:0015914 phospholipid transport 3/896 96/18722 0.844184302447603 0.971086242350296 TMEM30B/ANO6/DBI 3 GO:0035383 thioester metabolic process 3/896 96/18722 0.844184302447603 0.971086242350296 SLC25A1/ACSS1/TECR 3 GO:0043648 dicarboxylic acid metabolic process 3/896 96/18722 0.844184302447603 0.971086242350296 DHFR/GCLM/IDH2 3 GO:0044264 cellular polysaccharide metabolic process 3/896 96/18722 0.844184302447603 0.971086242350296 HMGB1/AGL/PHKB 3 GO:0008210 estrogen metabolic process 1/896 38/18722 0.845174557386988 0.971086242350296 PLEKHA1 1 GO:0009595 detection of biotic stimulus 1/896 38/18722 0.845174557386988 0.971086242350296 YAP1 1 GO:0010742 macrophage derived foam cell differentiation 1/896 38/18722 0.845174557386988 0.971086242350296 ITGAV 1 GO:0030279 negative regulation of ossification 1/896 38/18722 0.845174557386988 0.971086242350296 RBPJ 1 GO:0032373 positive regulation of sterol transport 1/896 38/18722 0.845174557386988 0.971086242350296 LRP1 1 GO:0032376 positive regulation of cholesterol transport 1/896 38/18722 0.845174557386988 0.971086242350296 LRP1 1 GO:0032941 secretion by tissue 1/896 38/18722 0.845174557386988 0.971086242350296 EGFR 1 GO:0035136 forelimb morphogenesis 1/896 38/18722 0.845174557386988 0.971086242350296 ATRX 1 GO:0035886 vascular associated smooth muscle cell differentiation 1/896 38/18722 0.845174557386988 0.971086242350296 DNMT1 1 GO:0046329 negative regulation of JNK cascade 1/896 38/18722 0.845174557386988 0.971086242350296 MARVELD3 1 GO:0072524 pyridine-containing compound metabolic process 1/896 38/18722 0.845174557386988 0.971086242350296 IDH2 1 GO:0090077 foam cell differentiation 1/896 38/18722 0.845174557386988 0.971086242350296 ITGAV 1 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1/896 38/18722 0.845174557386988 0.971086242350296 SLC25A5 1 GO:1903580 positive regulation of ATP metabolic process 1/896 38/18722 0.845174557386988 0.971086242350296 APP 1 GO:0009150 purine ribonucleotide metabolic process 14/896 368/18722 0.845469211356532 0.971191052698769 APP/DHTKD1/PARP1/GMPS/DLG1/SLC26A2/PPAT/PAICS/HINT1/SLC25A1/RAN/ACSS1/NUDT4/TECR 14 GO:0046883 regulation of hormone secretion 9/896 249/18722 0.84760583865488 0.973411179633966 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/KIF5B/LRP1 9 GO:0072521 purine-containing compound metabolic process 16/896 416/18722 0.84793903132197 0.973559628554854 APP/DHTKD1/PARP1/GMPS/DLG1/NUDT15/SLC26A2/PPAT/PAICS/HINT1/MTAP/SLC25A1/RAN/ACSS1/NUDT4/TECR 16 GO:0050810 regulation of steroid biosynthetic process 2/896 69/18722 0.84895957154829 0.974492657280649 ATP1A1/SF1 2 GO:1901216 positive regulation of neuron death 3/896 97/18722 0.849159919205593 0.974492657280649 PARP1/MYBL2/NF1 3 GO:0051090 regulation of DNA-binding transcription factor activity 17/896 440/18722 0.849394010167024 0.974527037860459 APP/EZH2/BMP7/LRP5/RTKN2/PKD2/TFDP1/FZD6/CDKN2A/DHX9/TAF3/SMARCA4/ID1/CREBZF/PURA/HDAC2/UFL1 17 GO:0009132 nucleoside diphosphate metabolic process 4/896 124/18722 0.850303395980301 0.975101708481854 APP/DHTKD1/DTYMK/DLG1 4 GO:0010508 positive regulation of autophagy 4/896 124/18722 0.850303395980301 0.975101708481854 HMGB1/LARP1/UFL1/SLC25A5 4 GO:0002701 negative regulation of production of molecular mediator of immune response 1/896 39/18722 0.852599284243189 0.97632741256344 PRKDC 1 GO:0017158 regulation of calcium ion-dependent exocytosis 1/896 39/18722 0.852599284243189 0.97632741256344 ATP2A2 1 GO:0034314 Arp2/3 complex-mediated actin nucleation 1/896 39/18722 0.852599284243189 0.97632741256344 IQGAP2 1 GO:0043267 negative regulation of potassium ion transport 1/896 39/18722 0.852599284243189 0.97632741256344 ANK3 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/896 39/18722 0.852599284243189 0.97632741256344 EZH2 1 GO:1901861 regulation of muscle tissue development 1/896 39/18722 0.852599284243189 0.97632741256344 CENPF 1 GO:0002548 monocyte chemotaxis 2/896 70/18722 0.854589589829567 0.978371870946368 HMGB1/ANO6 2 GO:0006163 purine nucleotide metabolic process 15/896 396/18722 0.85675162242949 0.979956213612562 APP/DHTKD1/PARP1/GMPS/DLG1/NUDT15/SLC26A2/PPAT/PAICS/HINT1/SLC25A1/RAN/ACSS1/NUDT4/TECR 15 GO:0061448 connective tissue development 9/896 252/18722 0.856966391180692 0.979956213612562 TYMS/EFEMP1/BMP7/ITGB8/LRP5/NFIB/GLG1/TRIP11/SERPINH1 9 GO:0001819 positive regulation of cytokine production 18/896 467/18722 0.857896789212864 0.979956213612562 HMGB2/HMGB1/APP/CADM1/BRCA1/HSP90AA1/SPTBN1/FZD5/ROCK2/CD46/FERMT1/G3BP1/DHX9/SETD2/HSPD1/HDAC2/HILPDA/LRP1 18 GO:0008643 carbohydrate transport 5/896 152/18722 0.858098480447493 0.979956213612562 SLC35B4/SLC5A3/SLC35D1/YES1/SLC2A1 5 GO:0006165 nucleoside diphosphate phosphorylation 3/896 99/18722 0.858697499097431 0.979956213612562 APP/DHTKD1/DTYMK 3 GO:0030838 positive regulation of actin filament polymerization 3/896 99/18722 0.858697499097431 0.979956213612562 IQGAP2/DLG1/MYO1C 3 GO:0042100 B cell proliferation 3/896 99/18722 0.858697499097431 0.979956213612562 SLC39A10/PAWR/HSPD1 3 GO:0051153 regulation of striated muscle cell differentiation 3/896 99/18722 0.858697499097431 0.979956213612562 EZH2/PARP2/FBXO22 3 GO:0060291 long-term synaptic potentiation 3/896 99/18722 0.858697499097431 0.979956213612562 APP/MME/PPP1R9A 3 GO:2001235 positive regulation of apoptotic signaling pathway 4/896 126/18722 0.858813094195664 0.979956213612562 SFPQ/PDIA3/MAGED1/BCLAF1 4 GO:0010863 positive regulation of phospholipase C activity 1/896 40/18722 0.859668333181695 0.979956213612562 EGFR 1 GO:0032094 response to food 1/896 40/18722 0.859668333181695 0.979956213612562 SLC16A1 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/896 40/18722 0.859668333181695 0.979956213612562 LGR4 1 GO:0070266 necroptotic process 1/896 40/18722 0.859668333181695 0.979956213612562 TRPM7 1 GO:0097352 autophagosome maturation 1/896 40/18722 0.859668333181695 0.979956213612562 ATP2A2 1 GO:1901223 negative regulation of NIK/NF-kappaB signaling 1/896 40/18722 0.859668333181695 0.979956213612562 BMP7 1 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 1/896 40/18722 0.859668333181695 0.979956213612562 SLC25A5 1 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 1/896 40/18722 0.859668333181695 0.979956213612562 NFAT5 1 GO:0061515 myeloid cell development 2/896 71/18722 0.860027442027665 0.980131536939621 FBN1/APP 2 GO:0060079 excitatory postsynaptic potential 3/896 100/18722 0.863265163147294 0.982915373803394 APP/SLC29A1/PPP1R9A 3 GO:0002253 activation of immune response 14/896 375/18722 0.863445219039853 0.982915373803394 HMGB1/PRKDC/HSP90AA1/SLC39A10/PAWR/CD46/SFPQ/PSPC1/KHDRBS1/YES1/PLEKHA1/NONO/XRCC5/XRCC6 14 GO:0002263 cell activation involved in immune response 10/896 279/18722 0.864379376932583 0.982915373803394 HMGB1/APP/RIF1/MSH6/MSH2/RNF168/CD46/UNG/HSPD1/LRP1 10 GO:0000271 polysaccharide biosynthetic process 2/896 72/18722 0.865278601172862 0.982915373803394 AGL/CLTC 2 GO:0030032 lamellipodium assembly 2/896 72/18722 0.865278601172862 0.982915373803394 ITGB1/VCL 2 GO:0032729 positive regulation of interferon-gamma production 2/896 72/18722 0.865278601172862 0.982915373803394 FZD5/HSPD1 2 GO:0070227 lymphocyte apoptotic process 2/896 72/18722 0.865278601172862 0.982915373803394 SLC39A10/AURKB 2 GO:0006418 tRNA aminoacylation for protein translation 1/896 41/18722 0.866398724653122 0.982915373803394 IARS2 1 GO:0030488 tRNA methylation 1/896 41/18722 0.866398724653122 0.982915373803394 TARBP1 1 GO:0048286 lung alveolus development 1/896 41/18722 0.866398724653122 0.982915373803394 ASXL1 1 GO:0048634 regulation of muscle organ development 1/896 41/18722 0.866398724653122 0.982915373803394 CENPF 1 GO:0050856 regulation of T cell receptor signaling pathway 1/896 41/18722 0.866398724653122 0.982915373803394 PAWR 1 GO:0050892 intestinal absorption 1/896 41/18722 0.866398724653122 0.982915373803394 LIMA1 1 GO:0060612 adipose tissue development 1/896 41/18722 0.866398724653122 0.982915373803394 LRP5 1 GO:1900371 regulation of purine nucleotide biosynthetic process 1/896 41/18722 0.866398724653122 0.982915373803394 PARP1 1 GO:1902622 regulation of neutrophil migration 1/896 41/18722 0.866398724653122 0.982915373803394 DPP4 1 GO:0032612 interleukin-1 production 4/896 128/18722 0.866906857435595 0.982915373803394 HMGB1/APP/FZD5/HDAC2 4 GO:0032652 regulation of interleukin-1 production 4/896 128/18722 0.866906857435595 0.982915373803394 HMGB1/APP/FZD5/HDAC2 4 GO:0033865 nucleoside bisphosphate metabolic process 4/896 128/18722 0.866906857435595 0.982915373803394 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0033875 ribonucleoside bisphosphate metabolic process 4/896 128/18722 0.866906857435595 0.982915373803394 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0034032 purine nucleoside bisphosphate metabolic process 4/896 128/18722 0.866906857435595 0.982915373803394 SLC26A2/SLC25A1/ACSS1/TECR 4 GO:0006576 cellular biogenic amine metabolic process 3/896 101/18722 0.867702536757398 0.982915373803394 SLC44A1/LY6E/ALDH7A1 3 GO:0042102 positive regulation of T cell proliferation 3/896 101/18722 0.867702536757398 0.982915373803394 HMGB1/CD46/CD24 3 GO:0046939 nucleotide phosphorylation 3/896 101/18722 0.867702536757398 0.982915373803394 APP/DHTKD1/DTYMK 3 GO:0007519 skeletal muscle tissue development 5/896 155/18722 0.869182379377383 0.982915373803394 NR2F2/SVIL/KLF5/FBXO22/DDX17 5 GO:0046434 organophosphate catabolic process 5/896 155/18722 0.869182379377383 0.982915373803394 DUT/NUDT15/UNG/HINT1/NUDT4 5 GO:0045766 positive regulation of angiogenesis 6/896 181/18722 0.869690690604758 0.982915373803394 HMGB1/BRCA1/ITGB1/NRP1/ITGB8/AGO2 6 GO:0097696 receptor signaling pathway via STAT 6/896 181/18722 0.869690690604758 0.982915373803394 SUZ12/CENPJ/PKD2/PRLR/HDAC2/OCIAD1 6 GO:1904018 positive regulation of vasculature development 6/896 181/18722 0.869690690604758 0.982915373803394 HMGB1/BRCA1/ITGB1/NRP1/ITGB8/AGO2 6 GO:0050848 regulation of calcium-mediated signaling 2/896 73/18722 0.870348457222639 0.982915373803394 CALM2/NFAT5 2 GO:0051865 protein autoubiquitination 2/896 73/18722 0.870348457222639 0.982915373803394 UBE2T/BRCA1 2 GO:0061035 regulation of cartilage development 2/896 73/18722 0.870348457222639 0.982915373803394 EFEMP1/GLG1 2 GO:0070988 demethylation 2/896 73/18722 0.870348457222639 0.982915373803394 TRIM28/USP9X 2 GO:1904427 positive regulation of calcium ion transmembrane transport 2/896 73/18722 0.870348457222639 0.982915373803394 PKD2/CALM2 2 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 4/896 129/18722 0.870802254291567 0.982915373803394 HMGB1/CASP8AP2/HSPD1/ANP32B 4 GO:0009914 hormone transport 11/896 306/18722 0.871425399825919 0.982915373803394 EGFR/DPP4/GJA1/LRP5/SOX4/SLC16A1/TM7SF3/CAMK2G/KIF5B/LRP1/FAM3B 11 GO:0016064 immunoglobulin mediated immune response 7/896 207/18722 0.871463205712713 0.982915373803394 RIF1/MSH6/MSH2/RNF168/CD46/UNG/HSPD1 7 GO:0034308 primary alcohol metabolic process 3/896 102/18722 0.872012453873543 0.982915373803394 ACSS1/AKR7A2/ADH5 3 GO:0045833 negative regulation of lipid metabolic process 3/896 102/18722 0.872012453873543 0.982915373803394 BRCA1/ATP1A1/ORMDL1 3 GO:1902106 negative regulation of leukocyte differentiation 3/896 102/18722 0.872012453873543 0.982915373803394 HMGB1/FBN1/CDK6 3 GO:0000266 mitochondrial fission 1/896 42/18722 0.872806665486632 0.982915373803394 AURKA 1 GO:0007520 myoblast fusion 1/896 42/18722 0.872806665486632 0.982915373803394 MYOF 1 GO:0030808 regulation of nucleotide biosynthetic process 1/896 42/18722 0.872806665486632 0.982915373803394 PARP1 1 GO:0030890 positive regulation of B cell proliferation 1/896 42/18722 0.872806665486632 0.982915373803394 SLC39A10 1 GO:0032689 negative regulation of interferon-gamma production 1/896 42/18722 0.872806665486632 0.982915373803394 HMGB1 1 GO:0043507 positive regulation of JUN kinase activity 1/896 42/18722 0.872806665486632 0.982915373803394 FZD5 1 GO:0048489 synaptic vesicle transport 1/896 42/18722 0.872806665486632 0.982915373803394 KIF5B 1 GO:1900274 regulation of phospholipase C activity 1/896 42/18722 0.872806665486632 0.982915373803394 EGFR 1 GO:1904037 positive regulation of epithelial cell apoptotic process 1/896 42/18722 0.872806665486632 0.982915373803394 ANO6 1 GO:2000404 regulation of T cell migration 1/896 42/18722 0.872806665486632 0.982915373803394 APP 1 GO:0060401 cytosolic calcium ion transport 6/896 182/18722 0.872970503755004 0.982915373803394 ATP2B1/MCOLN3/PKD2/CALM2/ATP2A2/AFG3L2 6 GO:0002573 myeloid leukocyte differentiation 7/896 208/18722 0.874517814418268 0.983302300882929 FBN1/APP/PARP1/LBR/ITGB8/CDK6/RBPJ 7 GO:0043467 regulation of generation of precursor metabolites and energy 4/896 130/18722 0.874599067287171 0.983302300882929 CCNB1/HMGB1/CDK1/APP 4 GO:0007040 lysosome organization 2/896 74/18722 0.875242312474006 0.983302300882929 HEXB/TMEM165 2 GO:0010822 positive regulation of mitochondrion organization 2/896 74/18722 0.875242312474006 0.983302300882929 AURKA/SLC25A5 2 GO:0080171 lytic vacuole organization 2/896 74/18722 0.875242312474006 0.983302300882929 HEXB/TMEM165 2 GO:1901568 fatty acid derivative metabolic process 2/896 74/18722 0.875242312474006 0.983302300882929 SLC25A1/TECR 2 GO:0007034 vacuolar transport 5/896 157/18722 0.876158469043382 0.983302300882929 VPS13A/HMGXB4/NEDD4/LRP1/HSPA8 5 GO:1902107 positive regulation of leukocyte differentiation 5/896 157/18722 0.876158469043382 0.983302300882929 HMGB1/PRKDC/SOX4/CD46/XRCC6 5 GO:1903708 positive regulation of hemopoiesis 5/896 157/18722 0.876158469043382 0.983302300882929 HMGB1/PRKDC/SOX4/CD46/XRCC6 5 GO:0002819 regulation of adaptive immune response 6/896 183/18722 0.876181074206596 0.983302300882929 HMGB1/RIF1/MSH2/FZD5/CD46/HSPD1 6 GO:0009135 purine nucleoside diphosphate metabolic process 3/896 103/18722 0.876197735223289 0.983302300882929 APP/DHTKD1/DLG1 3 GO:0009179 purine ribonucleoside diphosphate metabolic process 3/896 103/18722 0.876197735223289 0.983302300882929 APP/DHTKD1/DLG1 3 GO:0030004 cellular monovalent inorganic cation homeostasis 3/896 103/18722 0.876197735223289 0.983302300882929 ATP1A1/ATP1B3/TMEM165 3 GO:0045639 positive regulation of myeloid cell differentiation 3/896 103/18722 0.876197735223289 0.983302300882929 HMGB2/HMGB1/PRKDC 3 GO:0002861 regulation of inflammatory response to antigenic stimulus 1/896 43/18722 0.878907587741663 0.983635244380799 YES1 1 GO:0033173 calcineurin-NFAT signaling cascade 1/896 43/18722 0.878907587741663 0.983635244380799 NFAT5 1 GO:0034142 toll-like receptor 4 signaling pathway 1/896 43/18722 0.878907587741663 0.983635244380799 HMGB1 1 GO:0035794 positive regulation of mitochondrial membrane permeability 1/896 43/18722 0.878907587741663 0.983635244380799 SLC25A5 1 GO:0042088 T-helper 1 type immune response 1/896 43/18722 0.878907587741663 0.983635244380799 HMGB1 1 GO:0045494 photoreceptor cell maintenance 1/896 43/18722 0.878907587741663 0.983635244380799 SLC2A1 1 GO:0045981 positive regulation of nucleotide metabolic process 1/896 43/18722 0.878907587741663 0.983635244380799 APP 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/896 43/18722 0.878907587741663 0.983635244380799 HMGB1 1 GO:0060443 mammary gland morphogenesis 1/896 43/18722 0.878907587741663 0.983635244380799 LRP5 1 GO:0098815 modulation of excitatory postsynaptic potential 1/896 43/18722 0.878907587741663 0.983635244380799 APP 1 GO:1900544 positive regulation of purine nucleotide metabolic process 1/896 43/18722 0.878907587741663 0.983635244380799 APP 1 GO:0070372 regulation of ERK1 and ERK2 cascade 11/896 309/18722 0.878966894119918 0.983635244380799 HMGB1/EGFR/APP/NRP1/TPBG/SEMA6A/DLG1/GCNT2/EIF3A/FBLN1/LRP1 11 GO:0002292 T cell differentiation involved in immune response 2/896 75/18722 0.879965377604076 0.98429116979425 HMGB1/CD46 2 GO:0033077 T cell differentiation in thymus 2/896 75/18722 0.879965377604076 0.98429116979425 PRKDC/FZD5 2 GO:0019724 B cell mediated immunity 7/896 210/18722 0.880446893921215 0.984368494515195 RIF1/MSH6/MSH2/RNF168/CD46/UNG/HSPD1 7 GO:0045637 regulation of myeloid cell differentiation 7/896 210/18722 0.880446893921215 0.984368494515195 HMGB2/HMGB1/PRKDC/FBN1/MEIS2/CDK6/HSPA9 7 GO:0046395 carboxylic acid catabolic process 8/896 236/18722 0.882403749413912 0.986139404754235 SLC27A2/GLDC/ARHGAP11B/ACAT2/ENOSF1/PPAT/ECHDC2/HADHA 8 GO:1903169 regulation of calcium ion transmembrane transport 5/896 159/18722 0.882815945159396 0.986139404754235 TSPAN13/PKD2/CALM2/FMR1/AHNAK 5 GO:0046474 glycerophospholipid biosynthetic process 7/896 211/18722 0.883322901161689 0.986139404754235 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/SLC44A1 7 GO:0032543 mitochondrial translation 2/896 76/18722 0.884522768289382 0.986139404754235 IARS2/LRPPRC 2 GO:0043536 positive regulation of blood vessel endothelial cell migration 2/896 76/18722 0.884522768289382 0.986139404754235 HMGB1/NRP1 2 GO:2000379 positive regulation of reactive oxygen species metabolic process 2/896 76/18722 0.884522768289382 0.986139404754235 EGFR/SLC5A3 2 GO:0005978 glycogen biosynthetic process 1/896 44/18722 0.884716185706408 0.986139404754235 AGL 1 GO:0009250 glucan biosynthetic process 1/896 44/18722 0.884716185706408 0.986139404754235 AGL 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/896 44/18722 0.884716185706408 0.986139404754235 CADM1 1 GO:0042554 superoxide anion generation 1/896 44/18722 0.884716185706408 0.986139404754235 EGFR 1 GO:0043039 tRNA aminoacylation 1/896 44/18722 0.884716185706408 0.986139404754235 IARS2 1 GO:0051150 regulation of smooth muscle cell differentiation 1/896 44/18722 0.884716185706408 0.986139404754235 DNMT1 1 GO:0150076 neuroinflammatory response 1/896 44/18722 0.884716185706408 0.986139404754235 ITGB1 1 GO:1901617 organic hydroxy compound biosynthetic process 8/896 237/18722 0.885097685905055 0.986334349325567 SLC27A2/DHFR/LBR/DHCR24/PGP/FDPS/SQLE/ISYNA1 8 GO:0009259 ribonucleotide metabolic process 14/896 385/18722 0.88623972989589 0.987327640785905 APP/DHTKD1/PARP1/GMPS/DLG1/SLC26A2/PPAT/PAICS/HINT1/SLC25A1/RAN/ACSS1/NUDT4/TECR 14 GO:0060271 cilium assembly 12/896 337/18722 0.88733762370098 0.987327640785905 GALNT11/LAMA5/CENPJ/RAB3IP/CCP110/CEP135/YAP1/PCM1/DYNLL2/AHI1/ATMIN/ASAP1 12 GO:0046651 lymphocyte proliferation 10/896 288/18722 0.887711805840661 0.987327640785905 HELLS/HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/HSPD1/PURA/CD24 10 GO:0009185 ribonucleoside diphosphate metabolic process 3/896 106/18722 0.888033706896514 0.987327640785905 APP/DHTKD1/DLG1 3 GO:0019882 antigen processing and presentation 3/896 106/18722 0.888033706896514 0.987327640785905 CTSV/CALR/CTSL 3 GO:0042116 macrophage activation 3/896 106/18722 0.888033706896514 0.987327640785905 HMGB1/APP/HSPD1 3 GO:0099565 chemical synaptic transmission, postsynaptic 3/896 106/18722 0.888033706896514 0.987327640785905 APP/SLC29A1/PPP1R9A 3 GO:0001505 regulation of neurotransmitter levels 7/896 213/18722 0.888901730840964 0.987327640785905 SLC29A1/ITGB1/SLC38A1/SLC6A4/ATP2A2/PPP1R9A/FMR1 7 GO:0006367 transcription initiation from RNA polymerase II promoter 2/896 77/18722 0.888919502357717 0.987327640785905 HMGB1/ZNF451 2 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 9/896 264/18722 0.889900324424348 0.987327640785905 EGFR/APP/SUZ12/NRP1/NCAPG2/IQGAP1/YES1/HDAC2/CD24 9 GO:0002920 regulation of humoral immune response 1/896 45/18722 0.890246451131349 0.987327640785905 CD46 1 GO:0003009 skeletal muscle contraction 1/896 45/18722 0.890246451131349 0.987327640785905 ATP2A2 1 GO:0006110 regulation of glycolytic process 1/896 45/18722 0.890246451131349 0.987327640785905 APP 1 GO:0006903 vesicle targeting 1/896 45/18722 0.890246451131349 0.987327640785905 TRIP11 1 GO:0043038 amino acid activation 1/896 45/18722 0.890246451131349 0.987327640785905 IARS2 1 GO:0045933 positive regulation of muscle contraction 1/896 45/18722 0.890246451131349 0.987327640785905 ATP1A1 1 GO:0048546 digestive tract morphogenesis 1/896 45/18722 0.890246451131349 0.987327640785905 AHI1 1 GO:0071354 cellular response to interleukin-6 1/896 45/18722 0.890246451131349 0.987327640785905 YAP1 1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 1/896 45/18722 0.890246451131349 0.987327640785905 SLC25A5 1 GO:0072593 reactive oxygen species metabolic process 8/896 239/18722 0.890332110092861 0.987327640785905 EGFR/BMP7/BRCA1/DHFR/FOXM1/SLC5A3/PRDX4/HSPD1 8 GO:1903039 positive regulation of leukocyte cell-cell adhesion 8/896 239/18722 0.890332110092861 0.987327640785905 HMGB1/DPP4/SOX4/CD46/NFAT5/YES1/HSPD1/CD24 8 GO:0046394 carboxylic acid biosynthetic process 11/896 314/18722 0.89073867274515 0.987549099787586 SLC27A2/HACD3/BRCA1/DHFR/PLOD2/MTR/DEGS1/BCAT1/MTAP/ACSS1/TECR 11 GO:0006575 cellular modified amino acid metabolic process 6/896 188/18722 0.891229358389136 0.987863700243727 TYMS/GGH/DHFR/PLOD2/GCLM/ALDH7A1 6 GO:0006790 sulfur compound metabolic process 12/896 339/18722 0.891736587612449 0.988196487758086 MTR/GCLM/SLC26A2/CHST14/AHCYL1/CHPF/MTAP/SLC25A1/ACSS1/HSPA9/GLB1/TECR 12 GO:0002687 positive regulation of leukocyte migration 4/896 135/18722 0.892167574162599 0.988281480823257 HMGB1/APP/CALR/ANO6 4 GO:0060759 regulation of response to cytokine stimulus 5/896 162/18722 0.892227310923385 0.988281480823257 SPPL2A/DHX9/CD24/TRIM44/HSP90AB1 5 GO:0016054 organic acid catabolic process 8/896 240/18722 0.892873882943577 0.988768248010354 SLC27A2/GLDC/ARHGAP11B/ACAT2/ENOSF1/PPAT/ECHDC2/HADHA 8 GO:0090559 regulation of membrane permeability 2/896 78/18722 0.893160497429361 0.988856265011078 ARHGAP11B/SLC25A5 2 GO:0032943 mononuclear cell proliferation 10/896 291/18722 0.894717536524626 0.989852486264654 HELLS/HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/HSPD1/PURA/CD24 10 GO:0016053 organic acid biosynthetic process 11/896 316/18722 0.895177470121495 0.989852486264654 SLC27A2/HACD3/BRCA1/DHFR/PLOD2/MTR/DEGS1/BCAT1/MTAP/ACSS1/TECR 11 GO:0006633 fatty acid biosynthetic process 5/896 163/18722 0.895216305372011 0.989852486264654 HACD3/BRCA1/DEGS1/ACSS1/TECR 5 GO:0140053 mitochondrial gene expression 3/896 108/18722 0.895352015039147 0.989852486264654 TFAM/IARS2/LRPPRC 3 GO:0010830 regulation of myotube differentiation 1/896 46/18722 0.895511706781952 0.989852486264654 FBXO22 1 GO:0034198 cellular response to amino acid starvation 1/896 46/18722 0.895511706781952 0.989852486264654 SLC38A2 1 GO:0035094 response to nicotine 1/896 46/18722 0.895511706781952 0.989852486264654 HDAC2 1 GO:0050870 positive regulation of T cell activation 7/896 216/18722 0.89684877214433 0.991033799833285 HMGB1/DPP4/SOX4/CD46/YES1/HSPD1/CD24 7 GO:0051279 regulation of release of sequestered calcium ion into cytosol 2/896 79/18722 0.89725056900748 0.991033799833285 PKD2/CALM2 2 GO:0050671 positive regulation of lymphocyte proliferation 4/896 137/18722 0.898567930826059 0.991033799833285 HMGB1/SLC39A10/CD46/CD24 4 GO:0070374 positive regulation of ERK1 and ERK2 cascade 7/896 217/18722 0.899388619846089 0.991033799833285 HMGB1/EGFR/APP/NRP1/TPBG/GCNT2/LRP1 7 GO:0001754 eye photoreceptor cell differentiation 1/896 47/18722 0.900524638390614 0.991033799833285 TUG1 1 GO:0001774 microglial cell activation 1/896 47/18722 0.900524638390614 0.991033799833285 APP 1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1/896 47/18722 0.900524638390614 0.991033799833285 SPPL2A 1 GO:0016073 snRNA metabolic process 1/896 47/18722 0.900524638390614 0.991033799833285 EXOSC8 1 GO:0032008 positive regulation of TOR signaling 1/896 47/18722 0.900524638390614 0.991033799833285 RHEB 1 GO:0032369 negative regulation of lipid transport 1/896 47/18722 0.900524638390614 0.991033799833285 ITGAV 1 GO:0043114 regulation of vascular permeability 1/896 47/18722 0.900524638390614 0.991033799833285 YES1 1 GO:0045581 negative regulation of T cell differentiation 1/896 47/18722 0.900524638390614 0.991033799833285 HMGB1 1 GO:0045747 positive regulation of Notch signaling pathway 1/896 47/18722 0.900524638390614 0.991033799833285 YAP1 1 GO:0061001 regulation of dendritic spine morphogenesis 1/896 47/18722 0.900524638390614 0.991033799833285 PPP1R9A 1 GO:0090279 regulation of calcium ion import 1/896 47/18722 0.900524638390614 0.991033799833285 PKD2 1 GO:0097300 programmed necrotic cell death 1/896 47/18722 0.900524638390614 0.991033799833285 TRPM7 1 GO:0101023 vascular endothelial cell proliferation 1/896 47/18722 0.900524638390614 0.991033799833285 HMGB1 1 GO:1900744 regulation of p38MAPK cascade 1/896 47/18722 0.900524638390614 0.991033799833285 DLG1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/896 47/18722 0.900524638390614 0.991033799833285 HMGB1 1 GO:0032946 positive regulation of mononuclear cell proliferation 4/896 138/18722 0.901640865479804 0.991547570551946 HMGB1/SLC39A10/CD46/CD24 4 GO:0006939 smooth muscle contraction 3/896 110/18722 0.902237672073241 0.991547570551946 ATP2B1/DLG1/ROCK2 3 GO:0032611 interleukin-1 beta production 3/896 110/18722 0.902237672073241 0.991547570551946 HMGB1/APP/FZD5 3 GO:0032651 regulation of interleukin-1 beta production 3/896 110/18722 0.902237672073241 0.991547570551946 HMGB1/APP/FZD5 3 GO:1904659 glucose transmembrane transport 3/896 110/18722 0.902237672073241 0.991547570551946 SLC5A3/YES1/SLC2A1 3 GO:1905954 positive regulation of lipid localization 3/896 110/18722 0.902237672073241 0.991547570551946 HILPDA/LRP1/DBI 3 GO:0006091 generation of precursor metabolites and energy 18/896 490/18722 0.903147193806925 0.992318688891659 CCNB1/HMGB1/CDK1/APP/AGL/DHTKD1/ASPH/GLDC/MSH2/DEGS1/CYB5B/GFPT1/PHKB/ACSS1/AKR7A2/IDH2/CYB5A/ADH5 18 GO:0006096 glycolytic process 2/896 81/18722 0.904996684499352 0.992625041330223 APP/DHTKD1 2 GO:0002673 regulation of acute inflammatory response 1/896 48/18722 0.905297325084162 0.992625041330223 ASH1L 1 GO:0002686 negative regulation of leukocyte migration 1/896 48/18722 0.905297325084162 0.992625041330223 DPP4 1 GO:0002715 regulation of natural killer cell mediated immunity 1/896 48/18722 0.905297325084162 0.992625041330223 CADM1 1 GO:0044458 motile cilium assembly 1/896 48/18722 0.905297325084162 0.992625041330223 ATMIN 1 GO:0090311 regulation of protein deacetylation 1/896 48/18722 0.905297325084162 0.992625041330223 NCAPG2 1 GO:0097720 calcineurin-mediated signaling 1/896 48/18722 0.905297325084162 0.992625041330223 NFAT5 1 GO:1905710 positive regulation of membrane permeability 1/896 48/18722 0.905297325084162 0.992625041330223 SLC25A5 1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 1/896 48/18722 0.905297325084162 0.992625041330223 PDIA3 1 GO:0006805 xenobiotic metabolic process 3/896 111/18722 0.905524859965378 0.99264653994827 NUDT15/CYB5B/VKORC1 3 GO:0007159 leukocyte cell-cell adhesion 13/896 371/18722 0.906743994263381 0.993754781591686 HMGB1/BMP7/DPP4/ITGB1/PAWR/SOX4/DLG1/CD46/NFAT5/DLG5/YES1/HSPD1/CD24 13 GO:0071216 cellular response to biotic stimulus 8/896 246/18722 0.907109290849316 0.993926957657708 HMGB2/HMGB1/SMC1A/FZD5/CCDC47/HSPA5/PRPF8/PABPN1 8 GO:0019693 ribose phosphate metabolic process 14/896 396/18722 0.907673186660137 0.993954740308579 APP/DHTKD1/PARP1/GMPS/DLG1/SLC26A2/PPAT/PAICS/HINT1/SLC25A1/RAN/ACSS1/NUDT4/TECR 14 GO:0006757 ATP generation from ADP 2/896 82/18722 0.908661837203455 0.993954740308579 APP/DHTKD1 2 GO:0008543 fibroblast growth factor receptor signaling pathway 2/896 82/18722 0.908661837203455 0.993954740308579 SHCBP1/CEP57 2 GO:0009205 purine ribonucleoside triphosphate metabolic process 2/896 82/18722 0.908661837203455 0.993954740308579 PARP1/RAN 2 GO:0032609 interferon-gamma production 3/896 112/18722 0.908711742071249 0.993954740308579 HMGB1/FZD5/HSPD1 3 GO:0032649 regulation of interferon-gamma production 3/896 112/18722 0.908711742071249 0.993954740308579 HMGB1/FZD5/HSPD1 3 GO:0001913 T cell mediated cytotoxicity 1/896 49/18722 0.90984126835955 0.993954740308579 EMP2 1 GO:0007602 phototransduction 1/896 49/18722 0.90984126835955 0.993954740308579 CDS1 1 GO:0008206 bile acid metabolic process 1/896 49/18722 0.90984126835955 0.993954740308579 SLC27A2 1 GO:0042304 regulation of fatty acid biosynthetic process 1/896 49/18722 0.90984126835955 0.993954740308579 BRCA1 1 GO:0048168 regulation of neuronal synaptic plasticity 1/896 49/18722 0.90984126835955 0.993954740308579 APP 1 GO:0060986 endocrine hormone secretion 1/896 49/18722 0.90984126835955 0.993954740308579 GJA1 1 GO:0070741 response to interleukin-6 1/896 49/18722 0.90984126835955 0.993954740308579 YAP1 1 GO:0034341 response to interferon-gamma 4/896 141/18722 0.910371704232043 0.993976843156347 MYO1C/SYNCRIP/KIF5B/HSP90AB1 4 GO:1903038 negative regulation of leukocyte cell-cell adhesion 4/896 141/18722 0.910371704232043 0.993976843156347 HMGB1/PAWR/DLG1/DLG5 4 GO:0006816 calcium ion transport 15/896 422/18722 0.910486119631903 0.993976843156347 ATP2B1/ITGAV/TSPAN13/MCOLN3/GJA1/PKD2/CALM2/ATP2A2/TRPM7/AFG3L2/CAMK2G/FMR1/ANO6/AHNAK/TMEM165 15 GO:0042254 ribosome biogenesis 10/896 299/18722 0.911648584358643 0.994357544210018 PRKDC/NOP56/XPO1/EXOSC8/PA2G4/RAN/DDX17/XRCC5/RPS21/RPS17 10 GO:0044106 cellular amine metabolic process 3/896 113/18722 0.911800864688713 0.994357544210018 SLC44A1/LY6E/ALDH7A1 3 GO:0044344 cellular response to fibroblast growth factor stimulus 3/896 113/18722 0.911800864688713 0.994357544210018 SHCBP1/GCLM/CEP57 3 GO:0030098 lymphocyte differentiation 13/896 374/18722 0.912171779280132 0.994357544210018 HMGB1/PRKDC/EZH2/ITGB1/MSH2/SOX4/FZD5/PBX1/CD46/RBPJ/XRCC6/CTSL/SLC25A5 13 GO:0001510 RNA methylation 2/896 83/18722 0.912194282754464 0.994357544210018 ZC3H13/TARBP1 2 GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/896 83/18722 0.912194282754464 0.994357544210018 HMGB1/CTSL 2 GO:0010876 lipid localization 16/896 448/18722 0.913288335628611 0.994357544210018 SLC27A2/ITGAV/APOLD1/CDS1/VLDLR/TMEM30B/ASXL1/MEST/SQLE/HEXB/HILPDA/ANO6/LRP1/SLC2A1/LIMA1/DBI 16 GO:0001961 positive regulation of cytokine-mediated signaling pathway 1/896 50/18722 0.914167419676952 0.994357544210018 TRIM44 1 GO:0030490 maturation of SSU-rRNA 1/896 50/18722 0.914167419676952 0.994357544210018 RPS21 1 GO:0038093 Fc receptor signaling pathway 1/896 50/18722 0.914167419676952 0.994357544210018 YES1 1 GO:0038202 TORC1 signaling 1/896 50/18722 0.914167419676952 0.994357544210018 LARP1 1 GO:0045058 T cell selection 1/896 50/18722 0.914167419676952 0.994357544210018 CTSL 1 GO:0051646 mitochondrion localization 1/896 50/18722 0.914167419676952 0.994357544210018 LRPPRC 1 GO:0060337 type I interferon signaling pathway 1/896 50/18722 0.914167419676952 0.994357544210018 HSP90AB1 1 GO:1904036 negative regulation of epithelial cell apoptotic process 1/896 50/18722 0.914167419676952 0.994357544210018 YAP1 1 GO:2000677 regulation of transcription regulatory region DNA binding 1/896 50/18722 0.914167419676952 0.994357544210018 PARP1 1 GO:0008645 hexose transmembrane transport 3/896 114/18722 0.914794736820178 0.994554342455506 SLC5A3/YES1/SLC2A1 3 GO:0002088 lens development in camera-type eye 2/896 84/18722 0.915598310660233 0.994554342455506 FAT1/DLG1 2 GO:0015844 monoamine transport 2/896 84/18722 0.915598310660233 0.994554342455506 SLC6A4/LY6E 2 GO:0032370 positive regulation of lipid transport 2/896 84/18722 0.915598310660233 0.994554342455506 LRP1/DBI 2 GO:0097061 dendritic spine organization 2/896 84/18722 0.915598310660233 0.994554342455506 IGF1R/PPP1R9A 2 GO:1900542 regulation of purine nucleotide metabolic process 2/896 84/18722 0.915598310660233 0.994554342455506 APP/PARP1 2 GO:0048167 regulation of synaptic plasticity 6/896 198/18722 0.916697109148842 0.994556243270859 APP/MME/CDC20/YWHAH/PPP1R9A/FMR1 6 GO:1903131 mononuclear cell differentiation 15/896 426/18722 0.917053170501925 0.994556243270859 HMGB1/PRKDC/EZH2/ITGB1/ITGB8/MSH2/SOX4/FZD5/PBX1/CD46/CDK6/RBPJ/XRCC6/CTSL/SLC25A5 15 GO:0046916 cellular transition metal ion homeostasis 3/896 115/18722 0.917695829048278 0.994556243270859 APP/SLC39A10/MT2A 3 GO:0051209 release of sequestered calcium ion into cytosol 3/896 115/18722 0.917695829048278 0.994556243270859 MCOLN3/PKD2/CALM2 3 GO:0006364 rRNA processing 7/896 225/18722 0.917856444987059 0.994556243270859 PRKDC/NOP56/EXOSC8/PA2G4/DDX17/RPS21/RPS17 7 GO:0050670 regulation of lymphocyte proliferation 7/896 225/18722 0.917856444987059 0.994556243270859 HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/CD24 7 GO:0006636 unsaturated fatty acid biosynthetic process 1/896 51/18722 0.918286206736155 0.994556243270859 DEGS1 1 GO:0010874 regulation of cholesterol efflux 1/896 51/18722 0.918286206736155 0.994556243270859 LRP1 1 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 1/896 51/18722 0.918286206736155 0.994556243270859 HMGB1 1 GO:0045661 regulation of myoblast differentiation 1/896 51/18722 0.918286206736155 0.994556243270859 MBNL3 1 GO:0050982 detection of mechanical stimulus 1/896 51/18722 0.918286206736155 0.994556243270859 PKD2 1 GO:0071622 regulation of granulocyte chemotaxis 1/896 51/18722 0.918286206736155 0.994556243270859 DPP4 1 GO:0010821 regulation of mitochondrion organization 4/896 144/18722 0.918406675635204 0.994556243270859 AURKA/FZD5/HUWE1/SLC25A5 4 GO:0010507 negative regulation of autophagy 2/896 85/18722 0.918878104356384 0.994556243270859 MET/EIF4G1 2 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 2/896 85/18722 0.918878104356384 0.994556243270859 SUZ12/HDAC2 2 GO:0042098 T cell proliferation 6/896 199/18722 0.918933303114319 0.994556243270859 HMGB1/PAWR/DLG1/CD46/DLG5/CD24 6 GO:0002703 regulation of leukocyte mediated immunity 7/896 226/18722 0.919945396496009 0.995425957133261 HMGB1/CADM1/RIF1/MSH2/FZD5/CD46/HSPD1 7 GO:0015749 monosaccharide transmembrane transport 3/896 116/18722 0.920506572549408 0.995581870718367 SLC5A3/YES1/SLC2A1 3 GO:0051283 negative regulation of sequestering of calcium ion 3/896 116/18722 0.920506572549408 0.995581870718367 MCOLN3/PKD2/CALM2 3 GO:0032944 regulation of mononuclear cell proliferation 7/896 227/18722 0.921988176812954 0.99584231718487 HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/CD24 7 GO:0006140 regulation of nucleotide metabolic process 2/896 86/18722 0.922037741523246 0.99584231718487 APP/PARP1 2 GO:0015908 fatty acid transport 2/896 86/18722 0.922037741523246 0.99584231718487 SLC27A2/SLC2A1 2 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 1/896 52/18722 0.922207558499018 0.99584231718487 ERGIC2 1 GO:0010662 regulation of striated muscle cell apoptotic process 1/896 52/18722 0.922207558499018 0.99584231718487 BMP7 1 GO:0045010 actin nucleation 1/896 52/18722 0.922207558499018 0.99584231718487 IQGAP2 1 GO:0071357 cellular response to type I interferon 1/896 52/18722 0.922207558499018 0.99584231718487 HSP90AB1 1 GO:0002702 positive regulation of production of molecular mediator of immune response 3/896 117/18722 0.92322935823716 0.996492785196298 RIF1/MSH2/FZD5 3 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 4/896 146/18722 0.923399133268968 0.996492785196298 LGR5/ADGRG1/ADRB1/LGR4 4 GO:0045619 regulation of lymphocyte differentiation 5/896 174/18722 0.923629044906441 0.996492785196298 HMGB1/PRKDC/SOX4/CD46/XRCC6 5 GO:0006650 glycerophospholipid metabolic process 10/896 306/18722 0.924524099328544 0.996492785196298 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/PGP/SLC44A1/HADHA/DBI 10 GO:0001776 leukocyte homeostasis 2/896 87/18722 0.925081194615201 0.996492785196298 HMGB1/CCNB2 2 GO:1903578 regulation of ATP metabolic process 2/896 87/18722 0.925081194615201 0.996492785196298 APP/PARP1 2 GO:0019722 calcium-mediated signaling 6/896 202/18722 0.925330216808708 0.996492785196298 EGFR/CALM2/ATP2A2/NFAT5/PPP1R9A/NUDT4 6 GO:0051924 regulation of calcium ion transport 8/896 255/18722 0.925434685918386 0.996492785196298 ATP2B1/TSPAN13/GJA1/PKD2/CALM2/CAMK2G/FMR1/AHNAK 8 GO:0009308 amine metabolic process 3/896 118/18722 0.925866536028017 0.996492785196298 SLC44A1/LY6E/ALDH7A1 3 GO:0034219 carbohydrate transmembrane transport 3/896 118/18722 0.925866536028017 0.996492785196298 SLC5A3/YES1/SLC2A1 3 GO:0051282 regulation of sequestering of calcium ion 3/896 118/18722 0.925866536028017 0.996492785196298 MCOLN3/PKD2/CALM2 3 GO:0001541 ovarian follicle development 1/896 53/18722 0.925940929017758 0.996492785196298 ZFX 1 GO:0002707 negative regulation of lymphocyte mediated immunity 1/896 53/18722 0.925940929017758 0.996492785196298 CD46 1 GO:0043113 receptor clustering 1/896 53/18722 0.925940929017758 0.996492785196298 DLG1 1 GO:0097479 synaptic vesicle localization 1/896 53/18722 0.925940929017758 0.996492785196298 KIF5B 1 GO:0006644 phospholipid metabolic process 13/896 383/18722 0.926898820581391 0.997298843690683 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/PGP/SLC44A1/FDPS/HEXB/HADHA/DBI/ISYNA1 13 GO:0002440 production of molecular mediator of immune response 10/896 308/18722 0.927894787393511 0.997822268236452 PRKDC/RIF1/MSH6/POLQ/MSH2/RNF168/FZD5/UNG/HSPD1/CTNNBL1 10 GO:0006909 phagocytosis 10/896 308/18722 0.927894787393511 0.997822268236452 HMGB1/MET/COLEC12/ITGAV/ITGB1/CALR/YES1/ANO6/LRP1/TGM2 10 GO:0007260 tyrosine phosphorylation of STAT protein 2/896 88/18722 0.928012331581451 0.997822268236452 SUZ12/HDAC2 2 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/896 54/18722 0.929495320126017 0.998068074287361 CD46 1 GO:0006584 catecholamine metabolic process 1/896 54/18722 0.929495320126017 0.998068074287361 LY6E 1 GO:0006968 cellular defense response 1/896 54/18722 0.929495320126017 0.998068074287361 ITGB1 1 GO:0009712 catechol-containing compound metabolic process 1/896 54/18722 0.929495320126017 0.998068074287361 LY6E 1 GO:0043647 inositol phosphate metabolic process 1/896 54/18722 0.929495320126017 0.998068074287361 NUDT4 1 GO:1902743 regulation of lamellipodium organization 1/896 54/18722 0.929495320126017 0.998068074287361 KANK1 1 GO:0045165 cell fate commitment 8/896 258/18722 0.930806084396269 0.998153156703363 PRKDC/ITGB1/NRP1/NR2F2/ESRP1/RBPJ/LMO4/CTSL 8 GO:0009199 ribonucleoside triphosphate metabolic process 2/896 89/18722 0.930834916758684 0.998153156703363 PARP1/RAN 2 GO:0046330 positive regulation of JNK cascade 2/896 89/18722 0.930834916758684 0.998153156703363 HMGB1/APP 2 GO:0071774 response to fibroblast growth factor 3/896 120/18722 0.930893258991045 0.998153156703363 SHCBP1/GCLM/CEP57 3 GO:1903037 regulation of leukocyte cell-cell adhesion 11/896 336/18722 0.931896141618754 0.998153156703363 HMGB1/DPP4/PAWR/SOX4/DLG1/CD46/NFAT5/DLG5/YES1/HSPD1/CD24 11 GO:0001959 regulation of cytokine-mediated signaling pathway 4/896 150/18722 0.932568420028699 0.998153156703363 SPPL2A/CD24/TRIM44/HSP90AB1 4 GO:0070665 positive regulation of leukocyte proliferation 4/896 150/18722 0.932568420028699 0.998153156703363 HMGB1/SLC39A10/CD46/CD24 4 GO:0000768 syncytium formation by plasma membrane fusion 1/896 55/18722 0.932879303046903 0.998153156703363 MYOF 1 GO:0006414 translational elongation 1/896 55/18722 0.932879303046903 0.998153156703363 ASCC3 1 GO:0008333 endosome to lysosome transport 1/896 55/18722 0.932879303046903 0.998153156703363 HMGXB4 1 GO:0038066 p38MAPK cascade 1/896 55/18722 0.932879303046903 0.998153156703363 DLG1 1 GO:0045620 negative regulation of lymphocyte differentiation 1/896 55/18722 0.932879303046903 0.998153156703363 HMGB1 1 GO:0048016 inositol phosphate-mediated signaling 1/896 55/18722 0.932879303046903 0.998153156703363 NFAT5 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/896 55/18722 0.932879303046903 0.998153156703363 CD24 1 GO:0140253 cell-cell fusion 1/896 55/18722 0.932879303046903 0.998153156703363 MYOF 1 GO:0051251 positive regulation of lymphocyte activation 12/896 362/18722 0.932919854463847 0.998153156703363 HMGB1/PRKDC/RIF1/DPP4/SLC39A10/MSH2/SOX4/CD46/YES1/HSPD1/CD24/XRCC6 12 GO:1904019 epithelial cell apoptotic process 3/896 121/18722 0.933287293968997 0.998322550169839 YAP1/DNMT3A/ANO6 3 GO:0046031 ADP metabolic process 2/896 90/18722 0.933552611917593 0.99838265441187 APP/DHTKD1 2 GO:0055067 monovalent inorganic cation homeostasis 4/896 151/18722 0.934699981785624 0.998942936595801 ATP1A1/SNX5/ATP1B3/TMEM165 4 GO:0023061 signal release 16/896 463/18722 0.93478377610904 0.998942936595801 EGFR/WLS/DPP4/GJA1/LRP5/SOX4/SLC6A4/SLC16A1/ATP2A2/PPP1R9A/TM7SF3/CAMK2G/KIF5B/FMR1/LRP1/FAM3B 16 GO:0051928 positive regulation of calcium ion transport 3/896 122/18722 0.935604699935759 0.998942936595801 ATP2B1/PKD2/CALM2 3 GO:0050804 modulation of chemical synaptic transmission 15/896 439/18722 0.935686401096446 0.998942936595801 CDH1/EGFR/APP/MME/CDC20/ITGB1/CLSTN1/YWHAH/SLC6A4/ATP2A2/PPP1R9A/ZDHHC12/AKAP9/KIF5B/FMR1 15 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/896 56/18722 0.936101038969653 0.998942936595801 CADM1 1 GO:0010518 positive regulation of phospholipase activity 1/896 56/18722 0.936101038969653 0.998942936595801 EGFR 1 GO:0010658 striated muscle cell apoptotic process 1/896 56/18722 0.936101038969653 0.998942936595801 BMP7 1 GO:0045582 positive regulation of T cell differentiation 2/896 91/18722 0.936168977446504 0.998942936595801 SOX4/CD46 2 GO:0051952 regulation of amine transport 2/896 91/18722 0.936168977446504 0.998942936595801 ITGB1/ARL6IP1 2 GO:0060191 regulation of lipase activity 2/896 91/18722 0.936168977446504 0.998942936595801 EGFR/LRP1 2 GO:0099177 regulation of trans-synaptic signaling 15/896 440/18722 0.936959531239836 0.999563084276866 CDH1/EGFR/APP/MME/CDC20/ITGB1/CLSTN1/YWHAH/SLC6A4/ATP2A2/PPP1R9A/ZDHHC12/AKAP9/KIF5B/FMR1 15 GO:0030168 platelet activation 3/896 123/18722 0.937847614590472 0.999994666854411 DGKD/FZD6/VCL 3 GO:1905952 regulation of lipid localization 5/896 181/18722 0.937940988717788 0.999994666854411 ITGAV/ASXL1/HILPDA/LRP1/DBI 5 GO:0016072 rRNA metabolic process 7/896 236/18722 0.938421870870902 0.999994666854411 PRKDC/NOP56/EXOSC8/PA2G4/DDX17/RPS21/RPS17 7 GO:0006754 ATP biosynthetic process 1/896 57/18722 0.939168298644098 0.999994666854411 PARP1 1 GO:0030219 megakaryocyte differentiation 1/896 57/18722 0.939168298644098 0.999994666854411 HMGB2 1 GO:0050879 multicellular organismal movement 1/896 57/18722 0.939168298644098 0.999994666854411 ATP2A2 1 GO:0050881 musculoskeletal movement 1/896 57/18722 0.939168298644098 0.999994666854411 ATP2A2 1 GO:0051155 positive regulation of striated muscle cell differentiation 1/896 57/18722 0.939168298644098 0.999994666854411 PARP2 1 GO:0007368 determination of left/right symmetry 3/896 124/18722 0.940018132407253 0.999994666854411 GALNT11/PKD2/AHI1 3 GO:0006826 iron ion transport 1/896 58/18722 0.942088481039752 0.999994666854411 CLTC 1 GO:0010574 regulation of vascular endothelial growth factor production 1/896 58/18722 0.942088481039752 0.999994666854411 BRCA1 1 GO:0043506 regulation of JUN kinase activity 1/896 58/18722 0.942088481039752 0.999994666854411 FZD5 1 GO:0050432 catecholamine secretion 1/896 58/18722 0.942088481039752 0.999994666854411 LY6E 1 GO:0051147 regulation of muscle cell differentiation 4/896 155/18722 0.942628466954752 0.999994666854411 EZH2/PARP2/DNMT1/FBXO22 4 GO:0070661 leukocyte proliferation 10/896 318/18722 0.942874047685622 0.999994666854411 HELLS/HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/HSPD1/PURA/CD24 10 GO:0002042 cell migration involved in sprouting angiogenesis 2/896 94/18722 0.943444207548884 0.999994666854411 ITGB1/NRP1 2 GO:0030258 lipid modification 6/896 212/18722 0.943559582272826 0.999994666854411 SLC27A2/ACAT2/DGKD/ECHDC2/HADHA/ADH5 6 GO:0001836 release of cytochrome c from mitochondria 1/896 59/18722 0.94486863111414 0.999994666854411 GGCT 1 GO:0002820 negative regulation of adaptive immune response 1/896 59/18722 0.94486863111414 0.999994666854411 CD46 1 GO:0033013 tetrapyrrole metabolic process 1/896 59/18722 0.94486863111414 0.999994666854411 MTR 1 GO:0051353 positive regulation of oxidoreductase activity 1/896 59/18722 0.94486863111414 0.999994666854411 DHFR 1 GO:2000351 regulation of endothelial cell apoptotic process 1/896 59/18722 0.94486863111414 0.999994666854411 ANO6 1 GO:0042773 ATP synthesis coupled electron transport 2/896 95/18722 0.945688878638719 0.999994666854411 CCNB1/CDK1 2 GO:0042775 mitochondrial ATP synthesis coupled electron transport 2/896 95/18722 0.945688878638719 0.999994666854411 CCNB1/CDK1 2 GO:0051250 negative regulation of lymphocyte activation 4/896 157/18722 0.946254283744049 0.999994666854411 HMGB1/PAWR/DLG1/DLG5 4 GO:0044242 cellular lipid catabolic process 6/896 214/18722 0.946688225989528 0.999994666854411 SLC27A2/ACAT2/ECHDC2/HEXB/HADHA/LRP1 6 GO:0072330 monocarboxylic acid biosynthetic process 6/896 214/18722 0.946688225989528 0.999994666854411 SLC27A2/HACD3/BRCA1/DEGS1/ACSS1/TECR 6 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 1/896 60/18722 0.947515456732837 0.999994666854411 PUM1 1 GO:0042472 inner ear morphogenesis 2/896 96/18722 0.947848550472572 0.999994666854411 FZD6/TRIOBP 2 GO:1904035 regulation of epithelial cell apoptotic process 2/896 96/18722 0.947848550472572 0.999994666854411 YAP1/ANO6 2 GO:0019748 secondary metabolic process 1/896 61/18722 0.950035344781673 0.999994666854411 AKR7A2 1 GO:0043030 regulation of macrophage activation 1/896 61/18722 0.950035344781673 0.999994666854411 HSPD1 1 GO:0060997 dendritic spine morphogenesis 1/896 61/18722 0.950035344781673 0.999994666854411 PPP1R9A 1 GO:2000401 regulation of lymphocyte migration 1/896 61/18722 0.950035344781673 0.999994666854411 APP 1 GO:0044282 small molecule catabolic process 12/896 376/18722 0.950754429860187 0.999994666854411 SLC27A2/GLDC/ARHGAP11B/LRP5/ACAT2/FUT8/ENOSF1/PPAT/ECHDC2/HADHA/GLB1/ADH5 12 GO:0009060 aerobic respiration 5/896 189/18722 0.951313031451615 0.999994666854411 CCNB1/CDK1/DHTKD1/MSH2/IDH2 5 GO:0070663 regulation of leukocyte proliferation 7/896 245/18722 0.951721759641924 0.999994666854411 HMGB1/SLC39A10/PAWR/DLG1/CD46/DLG5/CD24 7 GO:0043473 pigmentation 2/896 98/18722 0.951924737219798 0.999994666854411 NF1/HPS5 2 GO:0002260 lymphocyte homeostasis 1/896 62/18722 0.952434376509641 0.999994666854411 CCNB2 1 GO:0032623 interleukin-2 production 1/896 62/18722 0.952434376509641 0.999994666854411 SPTBN1 1 GO:0032663 regulation of interleukin-2 production 1/896 62/18722 0.952434376509641 0.999994666854411 SPTBN1 1 GO:0032757 positive regulation of interleukin-8 production 1/896 62/18722 0.952434376509641 0.999994666854411 HMGB1 1 GO:0048488 synaptic vesicle endocytosis 1/896 62/18722 0.952434376509641 0.999994666854411 CANX 1 GO:0070265 necrotic cell death 1/896 62/18722 0.952434376509641 0.999994666854411 TRPM7 1 GO:0140238 presynaptic endocytosis 1/896 62/18722 0.952434376509641 0.999994666854411 CANX 1 GO:0051650 establishment of vesicle localization 4/896 161/18722 0.952884223124497 0.999994666854411 MYO1C/DYNC1H1/KIF5B/TRIP11 4 GO:0006661 phosphatidylinositol biosynthetic process 3/896 131/18722 0.953351504743626 0.999994666854411 PGAP1/CDS1/GPAA1 3 GO:0043410 positive regulation of MAPK cascade 16/896 480/18722 0.953512709448607 0.999994666854411 HMGB1/EGFR/APP/EZH2/NRP1/TPBG/IGF1R/GCNT2/FZD5/ROCK2/RYK/IQGAP1/LRP1/MAGED1/CD24/ERP29 16 GO:0015837 amine transport 2/896 99/18722 0.953846948315104 0.999994666854411 ITGB1/ARL6IP1 2 GO:0031341 regulation of cell killing 2/896 99/18722 0.953846948315104 0.999994666854411 CADM1/HSP90AB1 2 GO:0002704 negative regulation of leukocyte mediated immunity 1/896 63/18722 0.954718342139189 0.999994666854411 CD46 1 GO:0031343 positive regulation of cell killing 1/896 63/18722 0.954718342139189 0.999994666854411 CADM1 1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1/896 63/18722 0.954718342139189 0.999994666854411 ERP29 1 GO:0002366 leukocyte activation involved in immune response 8/896 275/18722 0.955311010135761 0.999994666854411 HMGB1/RIF1/MSH6/MSH2/RNF168/CD46/UNG/HSPD1 8 GO:0019218 regulation of steroid metabolic process 2/896 100/18722 0.955695556175672 0.999994666854411 ATP1A1/SF1 2 GO:0050863 regulation of T cell activation 10/896 329/18722 0.956146050982214 0.999994666854411 HMGB1/DPP4/PAWR/SOX4/DLG1/CD46/DLG5/YES1/HSPD1/CD24 10 GO:0009855 determination of bilateral symmetry 3/896 133/18722 0.956619155250073 0.999994666854411 GALNT11/PKD2/AHI1 3 GO:0006749 glutathione metabolic process 1/896 64/18722 0.956892754778842 0.999994666854411 GCLM 1 GO:0006940 regulation of smooth muscle contraction 1/896 64/18722 0.956892754778842 0.999994666854411 ATP2B1 1 GO:0017156 calcium-ion regulated exocytosis 1/896 64/18722 0.956892754778842 0.999994666854411 ATP2A2 1 GO:0045670 regulation of osteoclast differentiation 1/896 64/18722 0.956892754778842 0.999994666854411 FBN1 1 GO:0046888 negative regulation of hormone secretion 1/896 64/18722 0.956892754778842 0.999994666854411 GJA1 1 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 5/896 193/18722 0.956966300422686 0.999994666854411 NRP1/IQGAP1/YES1/HDAC2/CD24 5 GO:0002700 regulation of production of molecular mediator of immune response 4/896 164/18722 0.957353634592893 0.999994666854411 PRKDC/RIF1/MSH2/FZD5 4 GO:0046034 ATP metabolic process 8/896 277/18722 0.957612989514781 0.999994666854411 CCNB1/CDK1/APP/DHTKD1/PARP1/MSH2/FIGNL1/HSPA8 8 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3/896 134/18722 0.958171427317539 0.999994666854411 STMN1/MET/ROCK2 3 GO:0009799 specification of symmetry 3/896 134/18722 0.958171427317539 0.999994666854411 GALNT11/PKD2/AHI1 3 GO:0007286 spermatid development 4/896 165/18722 0.958754225809293 0.999994666854411 HMGB2/SMARCA2/SRPK1/CEP57 4 GO:0032635 interleukin-6 production 4/896 165/18722 0.958754225809293 0.999994666854411 HMGB1/APP/DHX9/HSPD1 4 GO:0032675 regulation of interleukin-6 production 4/896 165/18722 0.958754225809293 0.999994666854411 HMGB1/APP/DHX9/HSPD1 4 GO:0002720 positive regulation of cytokine production involved in immune response 1/896 65/18722 0.958962863671444 0.999994666854411 FZD5 1 GO:0033692 cellular polysaccharide biosynthetic process 1/896 65/18722 0.958962863671444 0.999994666854411 AGL 1 GO:0038034 signal transduction in absence of ligand 1/896 65/18722 0.958962863671444 0.999994666854411 ITGAV 1 GO:0072577 endothelial cell apoptotic process 1/896 65/18722 0.958962863671444 0.999994666854411 ANO6 1 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 1/896 65/18722 0.958962863671444 0.999994666854411 ITGAV 1 GO:0010522 regulation of calcium ion transport into cytosol 2/896 102/18722 0.959182407712758 0.999994666854411 PKD2/CALM2 2 GO:0035710 CD4-positive, alpha-beta T cell activation 2/896 102/18722 0.959182407712758 0.999994666854411 HMGB1/CTSL 2 GO:0045017 glycerolipid biosynthetic process 7/896 252/18722 0.960223167859865 0.999994666854411 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/SLC44A1 7 GO:0071674 mononuclear cell migration 5/896 196/18722 0.960805562757689 0.999994666854411 HMGB1/APP/EPS8/CALR/ANO6 5 GO:0030593 neutrophil chemotaxis 2/896 103/18722 0.960825668554133 0.999994666854411 DPP4/BSG 2 GO:0030193 regulation of blood coagulation 1/896 66/18722 0.960933666809696 0.999994666854411 ANO6 1 GO:0042093 T-helper cell differentiation 1/896 66/18722 0.960933666809696 0.999994666854411 HMGB1 1 GO:0042446 hormone biosynthetic process 1/896 66/18722 0.960933666809696 0.999994666854411 ATP1A1 1 GO:0072678 T cell migration 1/896 66/18722 0.960933666809696 0.999994666854411 APP 1 GO:0009583 detection of light stimulus 1/896 67/18722 0.962809922949196 0.999994666854411 CDS1 1 GO:0070527 platelet aggregation 1/896 67/18722 0.962809922949196 0.999994666854411 VCL 1 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 1/896 67/18722 0.962809922949196 0.999994666854411 HMGB1 1 GO:0002443 leukocyte mediated immunity 14/896 440/18722 0.962902609165209 0.999994666854411 TUBB/HMGB1/TUBB4B/CADM1/RIF1/MSH6/MSH2/EMP2/RNF168/FZD5/CD46/UNG/HSPD1/KIF5B 14 GO:0002237 response to molecule of bacterial origin 11/896 363/18722 0.963605450950613 0.999994666854411 HMGB2/HMGB1/GJA1/FZD5/ATP2A2/HSPD1/HDAC2/PRPF8/PABPN1/CD24/ADH5 11 GO:0060326 cell chemotaxis 9/896 310/18722 0.963783800542105 0.999994666854411 HMGB2/HMGB1/MET/DPP4/NRP1/TPBG/CALR/ANO6/BSG 9 GO:0009582 detection of abiotic stimulus 3/896 138/18722 0.963874349494416 0.999994666854411 TIMELESS/PKD2/CDS1 3 GO:0055076 transition metal ion homeostasis 3/896 138/18722 0.963874349494416 0.999994666854411 APP/SLC39A10/MT2A 3 GO:0016079 synaptic vesicle exocytosis 2/896 105/18722 0.963923806565166 0.999994666854411 ATP2A2/FMR1 2 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 1/896 68/18722 0.964596163047697 0.999994666854411 HMGB1 1 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 1/896 68/18722 0.964596163047697 0.999994666854411 PARP1 1 GO:0031640 killing of cells of other organism 1/896 68/18722 0.964596163047697 0.999994666854411 HMGN2 1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 1/896 68/18722 0.964596163047697 0.999994666854411 HDAC2 1 GO:0046637 regulation of alpha-beta T cell differentiation 1/896 68/18722 0.964596163047697 0.999994666854411 HMGB1 1 GO:1900046 regulation of hemostasis 1/896 68/18722 0.964596163047697 0.999994666854411 ANO6 1 GO:0006090 pyruvate metabolic process 2/896 106/18722 0.965383231558794 0.999994666854411 APP/DHTKD1 2 GO:0006906 vesicle fusion 2/896 106/18722 0.965383231558794 0.999994666854411 EEA1/KIF5B 2 GO:0002287 alpha-beta T cell activation involved in immune response 1/896 69/18722 0.966296701157982 0.999994666854411 HMGB1 1 GO:0002293 alpha-beta T cell differentiation involved in immune response 1/896 69/18722 0.966296701157982 0.999994666854411 HMGB1 1 GO:0009145 purine nucleoside triphosphate biosynthetic process 1/896 69/18722 0.966296701157982 0.999994666854411 PARP1 1 GO:0033344 cholesterol efflux 1/896 69/18722 0.966296701157982 0.999994666854411 LRP1 1 GO:0051966 regulation of synaptic transmission, glutamatergic 1/896 69/18722 0.966296701157982 0.999994666854411 EGFR 1 GO:0060193 positive regulation of lipase activity 1/896 69/18722 0.966296701157982 0.999994666854411 EGFR 1 GO:0046890 regulation of lipid biosynthetic process 4/896 171/18722 0.966301786384484 0.999994666854411 BRCA1/ATP1A1/SF1/ORMDL1 4 GO:0016197 endosomal transport 6/896 230/18722 0.966614003893398 0.999994666854411 SNX5/EEA1/RHOBTB3/CLTC/CMTM6/TINAGL1 6 GO:0051341 regulation of oxidoreductase activity 2/896 107/18722 0.966785802082936 0.999994666854411 EGFR/DHFR 2 GO:0048515 spermatid differentiation 4/896 172/18722 0.967427202068168 0.999994666854411 HMGB2/SMARCA2/SRPK1/CEP57 4 GO:0006119 oxidative phosphorylation 3/896 141/18722 0.967662323851079 0.999994666854411 CCNB1/CDK1/MSH2 3 GO:0045123 cellular extravasation 1/896 70/18722 0.967915644800423 0.999994666854411 ITGB1 1 GO:0034470 ncRNA processing 12/896 395/18722 0.968264656825815 0.999994666854411 PRKDC/NOP56/EXOSC8/LIN28B/AGO2/DICER1/HNRNPA2B1/TARBP1/PA2G4/DDX17/RPS21/RPS17 12 GO:0097553 calcium ion transmembrane import into cytosol 3/896 142/18722 0.96883938661205 0.999994666854411 MCOLN3/PKD2/CALM2 3 GO:0043550 regulation of lipid kinase activity 1/896 71/18722 0.969456904840034 0.999994666854411 RBL1 1 GO:0050818 regulation of coagulation 1/896 71/18722 0.969456904840034 0.999994666854411 ANO6 1 GO:0062013 positive regulation of small molecule metabolic process 3/896 143/18722 0.969975883876993 0.999994666854411 HMGB1/APP/DDB1 3 GO:0070555 response to interleukin-1 3/896 143/18722 0.969975883876993 0.999994666854411 APP/RBMX/USP10 3 GO:0015980 energy derivation by oxidation of organic compounds 9/896 318/18722 0.970617724281706 0.999994666854411 CCNB1/HMGB1/CDK1/AGL/DHTKD1/MSH2/GFPT1/PHKB/IDH2 9 GO:0002698 negative regulation of immune effector process 2/896 110/18722 0.97067295288806 0.999994666854411 PRKDC/CD46 2 GO:0030317 flagellated sperm motility 2/896 110/18722 0.97067295288806 0.999994666854411 VPS13A/ASH1L 2 GO:0090174 organelle membrane fusion 2/896 110/18722 0.97067295288806 0.999994666854411 EEA1/KIF5B 2 GO:0097722 sperm motility 2/896 110/18722 0.97067295288806 0.999994666854411 VPS13A/ASH1L 2 GO:0002534 cytokine production involved in inflammatory response 1/896 72/18722 0.970924204891684 0.999994666854411 EZH2 1 GO:1900015 regulation of cytokine production involved in inflammatory response 1/896 72/18722 0.970924204891684 0.999994666854411 EZH2 1 GO:0016236 macroautophagy 8/896 291/18722 0.970962397627154 0.999994666854411 ATP2A2/SNX5/NEDD4/HUWE1/LARP1/UFL1/RHEB/SLC25A5 8 GO:0002699 positive regulation of immune effector process 6/896 235/18722 0.971273976103004 0.999994666854411 CADM1/RIF1/MSH2/FZD5/CD46/HSPD1 6 GO:0007204 positive regulation of cytosolic calcium ion concentration 9/896 319/18722 0.971384365798347 0.999994666854411 HMGB1/ITGAV/MCOLN3/GJA1/PKD2/CALM2/LRP1/CD24/TGM2 9 GO:0050728 negative regulation of inflammatory response 4/896 176/18722 0.971587588341563 0.999994666854411 PBK/YES1/ASH1L/SERPINF1 4 GO:0015718 monocarboxylic acid transport 2/896 111/18722 0.971868330739852 0.999994666854411 SLC16A1/SLC16A12 2 GO:0007269 neurotransmitter secretion 3/896 145/18722 0.97213228860334 0.999994666854411 ATP2A2/PPP1R9A/FMR1 3 GO:0099643 signal release from synapse 3/896 145/18722 0.97213228860334 0.999994666854411 ATP2A2/PPP1R9A/FMR1 3 GO:0032456 endocytic recycling 1/896 73/18722 0.972321090275976 0.999994666854411 CMTM6 1 GO:0051145 smooth muscle cell differentiation 1/896 73/18722 0.972321090275976 0.999994666854411 DNMT1 1 GO:0051937 catecholamine transport 1/896 73/18722 0.972321090275976 0.999994666854411 LY6E 1 GO:0051648 vesicle localization 4/896 177/18722 0.972547115685661 0.999994666854411 MYO1C/DYNC1H1/KIF5B/TRIP11 4 GO:0002526 acute inflammatory response 2/896 112/18722 0.973016632352008 0.999994666854411 ASH1L/ANO6 2 GO:0046632 alpha-beta T cell differentiation 2/896 112/18722 0.973016632352008 0.999994666854411 HMGB1/CTSL 2 GO:0045580 regulation of T cell differentiation 3/896 146/18722 0.973154662491474 0.999994666854411 HMGB1/SOX4/CD46 3 GO:0009201 ribonucleoside triphosphate biosynthetic process 1/896 74/18722 0.973650936547236 0.999994666854411 PARP1 1 GO:0046323 glucose import 1/896 74/18722 0.973650936547236 0.999994666854411 SLC2A1 1 GO:0071347 cellular response to interleukin-1 2/896 113/18722 0.974119619156752 0.999994666854411 RBMX/USP10 2 GO:0006399 tRNA metabolic process 4/896 179/18722 0.974375830203983 0.999994666854411 EXOSC8/DICER1/IARS2/TARBP1 4 GO:0002685 regulation of leukocyte migration 5/896 210/18722 0.974895906985294 0.999994666854411 HMGB1/APP/DPP4/CALR/ANO6 5 GO:0036465 synaptic vesicle recycling 1/896 75/18722 0.974916957614036 0.999994666854411 CANX 1 GO:0048662 negative regulation of smooth muscle cell proliferation 1/896 75/18722 0.974916957614036 0.999994666854411 SF1 1 GO:0051453 regulation of intracellular pH 1/896 75/18722 0.974916957614036 0.999994666854411 TMEM165 1 GO:0002286 T cell activation involved in immune response 2/896 114/18722 0.97517899205562 0.999994666854411 HMGB1/CD46 2 GO:0022904 respiratory electron transport chain 2/896 114/18722 0.97517899205562 0.999994666854411 CCNB1/CDK1 2 GO:0034660 ncRNA metabolic process 15/896 485/18722 0.97582844265866 0.999994666854411 PRKDC/NOP56/EXOSC8/LIN28B/AGO2/DICER1/KCNQ1OT1/HNRNPA2B1/IARS2/TARBP1/PA2G4/KHSRP/DDX17/RPS21/RPS17 15 GO:0032368 regulation of lipid transport 3/896 149/18722 0.976012560734876 0.999994666854411 ITGAV/LRP1/DBI 3 GO:0051480 regulation of cytosolic calcium ion concentration 10/896 353/18722 0.97604928390488 0.999994666854411 HMGB1/ATP2B1/ITGAV/MCOLN3/GJA1/PKD2/CALM2/LRP1/CD24/TGM2 10 GO:0032720 negative regulation of tumor necrosis factor production 1/896 76/18722 0.976122213471698 0.999994666854411 DICER1 1 GO:0042471 ear morphogenesis 2/896 115/18722 0.976196393170794 0.999994666854411 FZD6/TRIOBP 2 GO:0090630 activation of GTPase activity 2/896 115/18722 0.976196393170794 0.999994666854411 ECT2/SYDE2 2 GO:0010827 regulation of glucose transmembrane transport 1/896 77/18722 0.977269617565303 0.999994666854411 YES1 1 GO:0032418 lysosome localization 1/896 77/18722 0.977269617565303 0.999994666854411 KIF5B 1 GO:0002696 positive regulation of leukocyte activation 12/896 409/18722 0.977357504090616 0.999994666854411 HMGB1/PRKDC/RIF1/DPP4/SLC39A10/MSH2/SOX4/CD46/YES1/HSPD1/CD24/XRCC6 12 GO:0043535 regulation of blood vessel endothelial cell migration 3/896 151/18722 0.977754564920228 0.999994666854411 HMGB1/NRP1/NF1 3 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 10/896 356/18722 0.977849999858025 0.999994666854411 HMGB1/RIF1/MSH6/MSH2/EMP2/RNF168/FZD5/CD46/UNG/HSPD1 10 GO:0030301 cholesterol transport 2/896 117/18722 0.978111564947321 0.999994666854411 LRP1/LIMA1 2 GO:0032371 regulation of sterol transport 1/896 78/18722 0.978361943800834 0.999994666854411 LRP1 1 GO:0032374 regulation of cholesterol transport 1/896 78/18722 0.978361943800834 0.999994666854411 LRP1 1 GO:0043537 negative regulation of blood vessel endothelial cell migration 1/896 78/18722 0.978361943800834 0.999994666854411 HMGB1 1 GO:0061045 negative regulation of wound healing 1/896 78/18722 0.978361943800834 0.999994666854411 GJA1 1 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 1/896 78/18722 0.978361943800834 0.999994666854411 NRP1 1 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 1/896 78/18722 0.978361943800834 0.999994666854411 DICER1 1 GO:0050871 positive regulation of B cell activation 3/896 152/18722 0.978579751610583 0.999994666854411 RIF1/SLC39A10/MSH2 3 GO:0051092 positive regulation of NF-kappaB transcription factor activity 3/896 152/18722 0.978579751610583 0.999994666854411 APP/RTKN2/DHX9 3 GO:0002040 sprouting angiogenesis 4/896 185/18722 0.979199558846846 0.999994666854411 HMGB1/ITGB1/NRP1/SEMA6A 4 GO:0001895 retina homeostasis 1/896 79/18722 0.979401833221262 0.999994666854411 SLC2A1 1 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 1/896 79/18722 0.979401833221262 0.999994666854411 HMGN2 1 GO:0050727 regulation of inflammatory response 11/896 386/18722 0.979425158682366 0.999994666854411 EGFR/APP/PBK/DHX9/YES1/HSPD1/ASH1L/BRD4/UFL1/SERPINF1/TGM2 11 GO:0002695 negative regulation of leukocyte activation 4/896 187/18722 0.980607522142278 0.999994666854411 HMGB1/PAWR/DLG1/DLG5 4 GO:0042445 hormone metabolic process 5/896 218/18722 0.980664662401735 0.999994666854411 MME/ENPEP/ATP1A1/PLEKHA1/CTSL 5 GO:0002761 regulation of myeloid leukocyte differentiation 2/896 120/18722 0.980707396194484 0.999994666854411 FBN1/CDK6 2 GO:0062012 regulation of small molecule metabolic process 9/896 334/18722 0.980899728684017 0.999994666854411 HMGB1/APP/PARP1/BRCA1/SLC35B4/SOGA1/PGP/RANBP2/DDB1 9 GO:0008589 regulation of smoothened signaling pathway 1/896 81/18722 0.981334239311856 0.999994666854411 DLG5 1 GO:0030641 regulation of cellular pH 1/896 81/18722 0.981334239311856 0.999994666854411 TMEM165 1 GO:0051149 positive regulation of muscle cell differentiation 1/896 81/18722 0.981334239311856 0.999994666854411 PARP2 1 GO:1902105 regulation of leukocyte differentiation 7/896 279/18722 0.981775364748991 0.999994666854411 HMGB1/PRKDC/FBN1/SOX4/CD46/CDK6/XRCC6 7 GO:0001910 regulation of leukocyte mediated cytotoxicity 1/896 82/18722 0.982231429461343 0.999994666854411 CADM1 1 GO:0007032 endosome organization 1/896 82/18722 0.982231429461343 0.999994666854411 EEA1 1 GO:1990266 neutrophil migration 2/896 122/18722 0.982269367248587 0.999994666854411 DPP4/BSG 2 GO:1902600 proton transmembrane transport 3/896 157/18722 0.982286433747828 0.999994666854411 ATP1A1/CYB5A/SLC25A5 3 GO:0071219 cellular response to molecule of bacterial origin 5/896 221/18722 0.982488188105286 0.999994666854411 HMGB2/HMGB1/FZD5/PRPF8/PABPN1 5 GO:0050867 positive regulation of cell activation 12/896 420/18722 0.98276794638518 0.999994666854411 HMGB1/PRKDC/RIF1/DPP4/SLC39A10/MSH2/SOX4/CD46/YES1/HSPD1/CD24/XRCC6 12 GO:0050852 T cell receptor signaling pathway 2/896 123/18722 0.983003611094176 0.999994666854411 PAWR/KHDRBS1 2 GO:1903706 regulation of hemopoiesis 10/896 367/18722 0.98344550295065 0.999994666854411 HMGB2/HMGB1/PRKDC/FBN1/MEIS2/SOX4/CD46/CDK6/HSPA9/XRCC6 10 GO:0046488 phosphatidylinositol metabolic process 3/896 159/18722 0.983590303063304 0.999994666854411 PGAP1/CDS1/GPAA1 3 GO:0002274 myeloid leukocyte activation 5/896 223/18722 0.983612813677987 0.999994666854411 HMGB1/APP/ITGB8/HSPD1/RBPJ 5 GO:0060402 calcium ion transport into cytosol 3/896 160/18722 0.984207293446876 0.999994666854411 MCOLN3/PKD2/CALM2 3 GO:0060294 cilium movement involved in cell motility 2/896 125/18722 0.984384551015814 0.999994666854411 VPS13A/ASH1L 2 GO:0071621 granulocyte chemotaxis 2/896 125/18722 0.984384551015814 0.999994666854411 DPP4/BSG 2 GO:0031929 TOR signaling 2/896 126/18722 0.985033493145627 0.999994666854411 LARP1/RHEB 2 GO:0032874 positive regulation of stress-activated MAPK cascade 2/896 126/18722 0.985033493145627 0.999994666854411 HMGB1/APP 2 GO:0032496 response to lipopolysaccharide 9/896 343/18722 0.98511265703511 0.999994666854411 HMGB2/HMGB1/GJA1/ATP2A2/HSPD1/HDAC2/PRPF8/PABPN1/ADH5 9 GO:0045921 positive regulation of exocytosis 1/896 86/18722 0.985409575960884 0.999994666854411 EXPH5 1 GO:0030217 T cell differentiation 6/896 257/18722 0.985481936407939 0.999994666854411 HMGB1/PRKDC/SOX4/FZD5/CD46/CTSL 6 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 2/896 128/18722 0.986253632912683 0.999994666854411 HMGB1/APP 2 GO:0030101 natural killer cell activation 1/896 88/18722 0.986778870344077 0.999994666854411 PBX1 1 GO:0050829 defense response to Gram-negative bacterium 1/896 88/18722 0.986778870344077 0.999994666854411 HMGB2 1 GO:0051091 positive regulation of DNA-binding transcription factor activity 6/896 260/18722 0.986804708139293 0.999994666854411 APP/LRP5/RTKN2/TFDP1/DHX9/SMARCA4 6 GO:0050864 regulation of B cell activation 4/896 198/18722 0.986874100030686 0.999994666854411 RIF1/SLC39A10/PAWR/MSH2 4 GO:0030595 leukocyte chemotaxis 5/896 230/18722 0.987036687681326 0.999994666854411 HMGB1/DPP4/CALR/ANO6/BSG 5 GO:0045333 cellular respiration 5/896 230/18722 0.987036687681326 0.999994666854411 CCNB1/CDK1/DHTKD1/MSH2/IDH2 5 GO:0016042 lipid catabolic process 8/896 320/18722 0.987274068325505 0.999994666854411 SLC27A2/ACAT2/YWHAH/STS/ECHDC2/HEXB/HADHA/LRP1 8 GO:0015918 sterol transport 2/896 130/18722 0.987376746667611 0.999994666854411 LRP1/LIMA1 2 GO:0042110 T cell activation 14/896 487/18722 0.987594098790495 0.999994666854411 HMGB1/PRKDC/DPP4/PAWR/SOX4/DLG1/FZD5/CD46/DLG5/YES1/HSPD1/CD24/DDOST/CTSL 14 GO:0099003 vesicle-mediated transport in synapse 4/896 200/18722 0.987783516929215 0.999994666854411 CLSTN1/ATP2A2/CANX/FMR1 4 GO:0050853 B cell receptor signaling pathway 2/896 131/18722 0.987904269798215 0.999994666854411 SLC39A10/PLEKHA1 2 GO:0006400 tRNA modification 1/896 90/18722 0.988019787933992 0.999994666854411 TARBP1 1 GO:0002275 myeloid cell activation involved in immune response 1/896 91/18722 0.98859590805052 0.999994666854411 HMGB1 1 GO:0006885 regulation of pH 1/896 91/18722 0.98859590805052 0.999994666854411 TMEM165 1 GO:0019935 cyclic-nucleotide-mediated signaling 1/896 91/18722 0.98859590805052 0.999994666854411 NUDT4 1 GO:0035249 synaptic transmission, glutamatergic 1/896 92/18722 0.989144352384519 0.999994666854411 EGFR 1 GO:0019217 regulation of fatty acid metabolic process 1/896 93/18722 0.989666449017019 0.999994666854411 BRCA1 1 GO:0033108 mitochondrial respiratory chain complex assembly 1/896 93/18722 0.989666449017019 0.999994666854411 TFAM 1 GO:0009581 detection of external stimulus 2/896 135/18722 0.989807628509297 0.999994666854411 PKD2/CDS1 2 GO:0001818 negative regulation of cytokine production 9/896 357/18722 0.989990372969117 0.999994666854411 HMGB1/ATP2B1/EZH2/SUZ12/LGR4/DICER1/CD2AP/CD24/HSP90AB1 9 GO:0030316 osteoclast differentiation 1/896 94/18722 0.990163462366138 0.999994666854411 FBN1 1 GO:1903035 negative regulation of response to wounding 1/896 94/18722 0.990163462366138 0.999994666854411 GJA1 1 GO:0099024 plasma membrane invagination 2/896 136/18722 0.990235787058788 0.999994666854411 AURKB/ANO6 2 GO:1903305 regulation of regulated secretory pathway 2/896 136/18722 0.990235787058788 0.999994666854411 ATP2A2/FMR1 2 GO:0002532 production of molecular mediator involved in inflammatory response 1/896 95/18722 0.990636596235579 0.999994666854411 EZH2 1 GO:0001539 cilium or flagellum-dependent cell motility 2/896 138/18722 0.991040076046491 0.999994666854411 VPS13A/ASH1L 2 GO:0007224 smoothened signaling pathway 2/896 138/18722 0.991040076046491 0.999994666854411 DLG5/HSPB11 2 GO:0060285 cilium-dependent cell motility 2/896 138/18722 0.991040076046491 0.999994666854411 VPS13A/ASH1L 2 GO:0002718 regulation of cytokine production involved in immune response 1/896 96/18722 0.991086996717295 0.999994666854411 FZD5 1 GO:0071222 cellular response to lipopolysaccharide 4/896 209/18722 0.991183038328629 0.999994666854411 HMGB2/HMGB1/PRPF8/PABPN1 4 GO:0006631 fatty acid metabolic process 10/896 390/18722 0.991191627923015 0.999994666854411 SLC27A2/HACD3/BRCA1/ACAT2/DEGS1/ECHDC2/HADHA/ACSS1/TECR/ADH5 10 GO:0050866 negative regulation of cell activation 4/896 210/18722 0.99149929330617 0.999994666854411 HMGB1/PAWR/DLG1/DLG5 4 GO:0046486 glycerolipid metabolic process 10/896 392/18722 0.991673094309036 0.999994666854411 CHPT1/PGAP1/SLC44A2/DGKD/CDS1/GPAA1/PGP/SLC44A1/HADHA/DBI 10 GO:0042180 cellular ketone metabolic process 4/896 211/18722 0.991804672104175 0.999994666854411 BRCA1/VKORC1/KDSR/AKR7A2 4 GO:0002367 cytokine production involved in immune response 1/896 98/18722 0.991923909777327 0.999994666854411 FZD5 1 GO:0000045 autophagosome assembly 1/896 99/18722 0.992312450200411 0.999994666854411 ATP2A2 1 GO:0007631 feeding behavior 1/896 99/18722 0.992312450200411 0.999994666854411 APP 1 GO:0033209 tumor necrosis factor-mediated signaling pathway 1/896 99/18722 0.992312450200411 0.999994666854411 SPPL2A 1 GO:0006910 phagocytosis, recognition 1/896 100/18722 0.992682317816823 0.999994666854411 COLEC12 1 GO:0007033 vacuole organization 3/896 180/18722 0.992751968358558 0.999994666854411 ATP2A2/HEXB/TMEM165 3 GO:0002697 regulation of immune effector process 8/896 339/18722 0.99278682475565 0.999994666854411 HMGB1/PRKDC/CADM1/RIF1/MSH2/FZD5/CD46/HSPD1 8 GO:0050900 leukocyte migration 9/896 369/18722 0.992938097235398 0.999994666854411 HMGB1/APP/DPP4/ITGB1/EPS8/CALR/YES1/ANO6/BSG 9 GO:0006869 lipid transport 10/896 398/18722 0.992973964941295 0.999994666854411 SLC27A2/ITGAV/APOLD1/VLDLR/TMEM30B/ANO6/LRP1/SLC2A1/LIMA1/DBI 10 GO:0099504 synaptic vesicle cycle 3/896 181/18722 0.993032791219239 0.999994666854411 ATP2A2/CANX/FMR1 3 GO:0050830 defense response to Gram-positive bacterium 1/896 101/18722 0.993034409065675 0.999994666854411 HMGB2 1 GO:0010324 membrane invagination 2/896 144/18722 0.993083823587062 0.999994666854411 AURKB/ANO6 2 GO:0032677 regulation of interleukin-8 production 1/896 102/18722 0.993369577395902 0.999994666854411 HMGB1 1 GO:0019932 second-messenger-mediated signaling 7/896 312/18722 0.99341061586148 0.999994666854411 EGFR/CALM2/ATP2A2/DGKD/NFAT5/PPP1R9A/NUDT4 7 GO:0019233 sensory perception of pain 1/896 103/18722 0.993688635325723 0.999994666854411 MME 1 GO:0032637 interleukin-8 production 1/896 103/18722 0.993688635325723 0.999994666854411 HMGB1 1 GO:1905037 autophagosome organization 1/896 103/18722 0.993688635325723 0.999994666854411 ATP2A2 1 GO:0015850 organic hydroxy compound transport 6/896 284/18722 0.993972932839204 0.999994666854411 SLC6A4/SLC16A1/SLC5A3/LY6E/LRP1/LIMA1 6 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1/896 104/18722 0.993992356403555 0.999994666854411 TGM2 1 GO:0022600 digestive system process 1/896 104/18722 0.993992356403555 0.999994666854411 LIMA1 1 GO:0032006 regulation of TOR signaling 1/896 104/18722 0.993992356403555 0.999994666854411 RHEB 1 GO:0046634 regulation of alpha-beta T cell activation 1/896 104/18722 0.993992356403555 0.999994666854411 HMGB1 1 GO:0097529 myeloid leukocyte migration 4/896 220/18722 0.994118551261302 0.999994666854411 HMGB1/DPP4/ANO6/BSG 4 GO:0097530 granulocyte migration 2/896 148/18722 0.994184895885 0.999994666854411 DPP4/BSG 2 GO:0002683 negative regulation of immune system process 11/896 434/18722 0.994310429969658 0.999994666854411 HMGB1/PRKDC/FBN1/DPP4/PAWR/DLG1/CD46/DLG5/CDK6/YES1/HSPA9 11 GO:0006958 complement activation, classical pathway 1/896 108/18722 0.995068081307959 0.999994666854411 CD46 1 GO:0002764 immune response-regulating signaling pathway 12/896 468/18722 0.995136826707663 0.999994666854411 HMGB1/COLEC12/SLC39A10/PAWR/LGR4/KHDRBS1/YES1/PLEKHA1/HSPD1/PUM1/CD24/RTN4 12 GO:0018958 phenol-containing compound metabolic process 1/896 110/18722 0.995531469734494 0.999994666854411 LY6E 1 GO:0071356 cellular response to tumor necrosis factor 4/896 229/18722 0.995797158956217 0.999994666854411 BRCA1/SPPL2A/DHX9/PRPF8 4 GO:0046631 alpha-beta T cell activation 2/896 156/18722 0.995896491347682 0.999994666854411 HMGB1/CTSL 2 GO:0001676 long-chain fatty acid metabolic process 1/896 112/18722 0.995951363565737 0.999994666854411 SLC27A2 1 GO:0032102 negative regulation of response to external stimulus 10/896 420/18722 0.99628822070502 0.999994666854411 PBK/DPP4/NRP1/SEMA6D/GJA1/SEMA6A/RYK/YES1/ASH1L/SERPINF1 10 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 4/896 233/18722 0.99638494347215 0.999994666854411 LGR5/ADGRG1/ADRB1/LGR4 4 GO:0033559 unsaturated fatty acid metabolic process 1/896 116/18722 0.996676598859247 0.999994666854411 DEGS1 1 GO:0072676 lymphocyte migration 1/896 117/18722 0.99683664225504 0.999994666854411 APP 1 GO:0017157 regulation of exocytosis 3/896 202/18722 0.996994987232207 0.999994666854411 EXPH5/ATP2A2/FMR1 3 GO:0050851 antigen receptor-mediated signaling pathway 4/896 240/18722 0.997227835681018 0.999994666854411 SLC39A10/PAWR/KHDRBS1/PLEKHA1 4 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/896 121/18722 0.99740343812396 0.999994666854411 CD46 1 GO:0009451 RNA modification 2/896 167/18722 0.997468362392476 0.999994666854411 ZC3H13/TARBP1 2 GO:0019730 antimicrobial humoral response 1/896 122/18722 0.997528513089872 0.999994666854411 HMGN2 1 GO:0002768 immune response-regulating cell surface receptor signaling pathway 6/896 315/18722 0.997906893322685 0.999994666854411 SLC39A10/PAWR/KHDRBS1/YES1/PLEKHA1/CD24 6 GO:0006911 phagocytosis, engulfment 1/896 127/18722 0.9980691933801 0.999994666854411 ANO6 1 GO:0008033 tRNA processing 1/896 127/18722 0.9980691933801 0.999994666854411 TARBP1 1 GO:0006639 acylglycerol metabolic process 1/896 128/18722 0.998162229289292 0.999994666854411 DGKD 1 GO:0003341 cilium movement 2/896 175/18722 0.998222510598515 0.999994666854411 VPS13A/ASH1L 2 GO:0006638 neutral lipid metabolic process 1/896 129/18722 0.998250787026024 0.999994666854411 DGKD 1 GO:0034612 response to tumor necrosis factor 4/896 253/18722 0.998316741434417 0.999994666854411 BRCA1/SPPL2A/DHX9/PRPF8 4 GO:0006956 complement activation 1/896 130/18722 0.998335081912524 0.999994666854411 CD46 1 GO:0002429 immune response-activating cell surface receptor signaling pathway 5/896 291/18722 0.998503088505245 0.999994666854411 SLC39A10/PAWR/KHDRBS1/YES1/PLEKHA1 5 GO:0002757 immune response-activating signal transduction 5/896 291/18722 0.998503088505245 0.999994666854411 SLC39A10/PAWR/KHDRBS1/YES1/PLEKHA1 5 GO:0010565 regulation of cellular ketone metabolic process 1/896 133/18722 0.998564390512996 0.999994666854411 BRCA1 1 GO:0031348 negative regulation of defense response 4/896 258/18722 0.998613295579532 0.999994666854411 PBK/YES1/ASH1L/SERPINF1 4 GO:0007586 digestion 1/896 137/18722 0.998821821697956 0.999994666854411 LIMA1 1 GO:0034754 cellular hormone metabolic process 1/896 137/18722 0.998821821697956 0.999994666854411 PLEKHA1 1 GO:0050777 negative regulation of immune response 2/896 194/18722 0.99923812477916 0.999994666854411 CD46/YES1 2 GO:0007601 visual perception 2/896 215/18722 0.999704366479648 0.999994666854411 EFEMP1/TACSTD2 2 GO:0016050 vesicle organization 4/896 300/18722 0.999737658236569 0.999994666854411 FBXO5/EEA1/KIF5B/CD2AP 4 GO:0050953 sensory perception of light stimulus 2/896 219/18722 0.999753413277331 0.999994666854411 EFEMP1/TACSTD2 2 GO:0045055 regulated exocytosis 2/896 230/18722 0.999850514397902 0.999994666854411 ATP2A2/FMR1 2 GO:0006887 exocytosis 5/896 352/18722 0.999852904968259 0.999994666854411 PRSS12/EXPH5/RAB3IP/ATP2A2/FMR1 5 GO:0019216 regulation of lipid metabolic process 4/896 331/18722 0.999925996629425 0.999994666854411 BRCA1/ATP1A1/SF1/ORMDL1 4 GO:0019221 cytokine-mediated signaling pathway 7/896 472/18722 0.999976264634218 0.999994666854411 YAP1/SPPL2A/PRLR/P4HB/CD24/TRIM44/HSP90AB1 7 GO:0006959 humoral immune response 3/896 317/18722 0.999977078872219 0.999994666854411 HMGN2/CD46/RBPJ 3 GO:0042742 defense response to bacterium 3/896 350/18722 0.999994666854411 0.999994666854411 HMGB2/COLEC12/RBPJ 3