ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0023026	MHC class II protein complex binding	17/1094	27/18367	6.34216561105638e-15	6.01871516489251e-12	HLA-DRA/HLA-DRB1/HLA-DPA1/CD74/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/B2M/CD81/HLA-DMB/HLA-DQA2/CD4/HLA-DOA/HLA-DRB5/ATP1B1/PKM	17
GO:0023023	MHC protein complex binding	19/1094	36/18367	1.48689700408331e-14	7.05532628437530e-12	HLA-DRA/HLA-DRB1/HLA-DPA1/CD74/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/B2M/CD81/HLA-DMB/HLA-DQA2/CD4/LILRB1/HLA-DOA/LILRB2/HLA-DRB5/ATP1B1/PKM	19
GO:0003779	actin binding	66/1094	440/18367	3.30915012322833e-12	1.04679448898123e-09	TMSB4X/MARCKS/CAPG/AIF1/S100A4/CXCR4/FXYD5/YWHAH/LSP1/CCDC88A/COTL1/LCP1/MSN/PHACTR1/GBP1/ACTR2/ACTR3/FLNA/TPM3/WIPF1/GMFG/TMSB10/CORO1C/TWF2/CORO1A/PARVG/ARPC3/FMNL1/WAS/STK38L/FKBP15/PPP1R18/MYO5A/ABI3/VASH1/PDLIM7/MYO9B/MYO1F/FGD4/LASP1/FMNL3/RCSD1/FHL3/MYO1G/KLHL5/LRRK2/VASP/TLN1/CAP1/ARPC4/ARPC1B/CAPZA2/CAPZA1/CYFIP1/SHTN1/IQGAP1/GSN/FLII/ARPC5/HCLS1/CFL1/DBNL/FMNL2/PLEC/CAPZB/PFN1	66
GO:0140375	immune receptor activity	31/1094	144/18367	3.13007198801429e-10	7.20301004874927e-08	HLA-DRA/HLA-DRB1/HLA-DPA1/CD74/HLA-DQB1/HLA-DQA1/FCER1G/CXCR4/FPR3/CTSH/CD44/HLA-DQA2/C5AR1/C3AR1/IFNGR2/IFNGR1/CD4/IL13RA1/FPR1/FCGR1B/LILRB1/HLA-DOA/IL10RA/CCR1/LILRB3/LILRB2/CCRL2/IL6R/LILRA2/IFNAR1/MR1	31
GO:0051020	GTPase binding	47/1094	291/18367	3.79505271272354e-10	7.20301004874927e-08	SORL1/LCP1/NCF2/ARHGDIB/DOCK4/FLNA/CORO1C/YBX1/CIB1/RAP1A/FMNL1/WAS/GGA2/DMXL2/MYO5A/RRAGD/MYO9B/FGD4/FMNL3/RIN3/LRRK2/DENND1B/ARHGEF2/GGA1/RAB29/TMEM127/CYFIP1/RAC1/ATP6AP1/ABCA1/IQGAP1/PAK2/ROCK1/GNB1/PAK1/DENND5A/BRK1/PICALM/AKAP13/RCC2/GDI2/RANBP2/ARHGDIA/RAB8A/FMNL2/KPNB1/PFN1	47
GO:0031267	small GTPase binding	43/1094	259/18367	8.87280976710922e-10	1.40338274483111e-07	SORL1/NCF2/ARHGDIB/DOCK4/FLNA/CORO1C/CIB1/RAP1A/FMNL1/WAS/GGA2/DMXL2/MYO5A/MYO9B/FGD4/FMNL3/RIN3/LRRK2/DENND1B/ARHGEF2/GGA1/RAB29/TMEM127/CYFIP1/RAC1/ATP6AP1/ABCA1/IQGAP1/PAK2/ROCK1/PAK1/DENND5A/BRK1/PICALM/AKAP13/RCC2/GDI2/RANBP2/ARHGDIA/RAB8A/FMNL2/KPNB1/PFN1	43
GO:0051015	actin filament binding	37/1094	217/18367	6.30881413491029e-09	8.52483256775261e-07	MARCKS/CAPG/AIF1/COTL1/LCP1/ACTR2/ACTR3/FLNA/TPM3/CORO1C/TWF2/CORO1A/ARPC3/FMNL1/MYO5A/ABI3/MYO1F/LASP1/FMNL3/RCSD1/MYO1G/TLN1/ARPC4/ARPC1B/CAPZA2/CAPZA1/CYFIP1/SHTN1/IQGAP1/GSN/FLII/ARPC5/HCLS1/CFL1/DBNL/FMNL2/CAPZB	37
GO:0042605	peptide antigen binding	14/1094	36/18367	7.18637097386943e-09	8.52483256775261e-07	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-A/HLA-B/HLA-C/HLA-E/HLA-F/TAPBP/TAP1/HLA-DRB5	14
GO:0033218	amide binding	54/1094	400/18367	1.45174966172839e-08	1.53078936553361e-06	APOE/HLA-DRA/HLA-DRB1/HLA-DPA1/CD74/HLA-DPB1/HLA-DQB1/HLA-DQA1/MSR1/HLA-A/PSAP/HLA-B/HLA-C/TREM2/C1QA/CST3/HLA-E/ITGB2/SORL1/CD14/TPP1/CD36/HLA-F/SOAT1/NUP214/MARCO/TLR2/PLTP/MGST1/TAPBP/TLR4/ANPEP/PRNP/TLR1/TAP1/CRIP1/LILRB2/ITGAM/HLA-DRB5/NQO2/CD300LF/FKBP5/ERAP2/MGST2/KPNA3/LRP1/NFKBIA/ACBD5/PFDN5/PICALM/SCP2/PIK3R1/KPNB1/PPIF	54
GO:0042277	peptide binding	46/1094	321/18367	2.7880834205928e-08	2.64589116614257e-06	APOE/HLA-DRA/HLA-DRB1/HLA-DPA1/CD74/HLA-DPB1/HLA-DQB1/HLA-DQA1/MSR1/HLA-A/HLA-B/HLA-C/TREM2/C1QA/CST3/HLA-E/ITGB2/SORL1/CD14/TPP1/CD36/HLA-F/NUP214/MARCO/TLR2/MGST1/TAPBP/TLR4/ANPEP/PRNP/TLR1/TAP1/CRIP1/LILRB2/ITGAM/HLA-DRB5/ERAP2/MGST2/KPNA3/LRP1/NFKBIA/PFDN5/PICALM/PIK3R1/KPNB1/PPIF	46
GO:0003924	GTPase activity	47/1094	337/18367	4.61744182919862e-08	3.98359299628135e-06	RGS1/RGS10/MX1/ARHGDIB/ARL5A/RAB32/RAP2B/GBP1/GNAI2/TUBA1A/RHOA/GBP4/RGS19/RHOQ/RAP1A/MX2/RHOG/GBP2/RRAGD/GBP5/GNA15/RGS18/LRRK2/RRAS/RIT1/RAP2A/GNA13/RAB29/RAB8B/RALA/RAC1/ATL3/ARL8B/GNB1/EIF2S3/RHOB/RAB5C/GNAQ/ARF6/CDC42/ARL4C/RGS2/RAB10/ARF3/RAB8A/RAB7A/RAB13	47
GO:0019003	GDP binding	19/1094	75/18367	5.36554675812695e-08	4.24325322788539e-06	RAP2B/GBP1/RHOA/RAP1A/RRAGD/RRAS/RIT1/RAP2A/RAB29/RAB8B/RALA/ARL8B/RHOB/RAB5C/ARF6/DYNC1LI1/RAB10/RAB8A/RAB7A	19
GO:0032395	MHC class II receptor activity	7/1094	10/18367	2.67258186089815e-07	1.95098475845565e-05	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQB1/HLA-DQA1/HLA-DQA2/HLA-DOA	7
GO:0005525	GTP binding	48/1094	377/18367	5.40206621243206e-07	3.6618291682843e-05	SAMHD1/IFI44L/MX1/ARL5A/RAB32/RAP2B/GBP1/GNAI2/TUBA1A/GIMAP4/RHOA/GBP4/RHOQ/RAP1A/MX2/RHOG/GBP2/CIITA/RRAGD/GBP5/GIMAP1/GIMAP2/EHD4/GNA15/LRRK2/RRAS/RIT1/RAP2A/GNA13/RAB29/RAB8B/RALA/RAC1/ATL3/DAPK1/ARL8B/EIF2S3/RHOB/RAB5C/GNAQ/ARF6/CDC42/ARL4C/RAB10/ARF3/RAB8A/RAB7A/RAB13	48
GO:0017124	SH3 domain binding	24/1094	130/18367	6.45708755180839e-07	4.08518405777744e-05	GPX1/CYBA/SH3BGRL/GRB2/DOCK4/LYN/PLSCR1/WIPF1/SIRPA/WAS/ABI3/NCF1/PTPN6/SH3BP2/INPP5D/VASP/ADAM9/ABI1/QKI/SH3KBP1/ADAM17/HCLS1/ADAM10/ZNF106	24
GO:0019001	guanyl nucleotide binding	49/1094	398/18367	1.11544055721991e-06	6.22678287530409e-05	SAMHD1/IFI44L/MX1/ARL5A/RAB32/RAP2B/GBP1/GNAI2/TUBA1A/GIMAP4/RHOA/GBP4/RHOQ/RAP1A/MX2/RHOG/GBP2/CIITA/RRAGD/GBP5/GIMAP1/GIMAP2/EHD4/GNA15/LRRK2/RRAS/RIT1/RAP2A/GNA13/RAB29/RAB8B/RALA/RAC1/ATL3/DAPK1/ARL8B/EIF2S3/RHOB/RAB5C/GNAQ/ARF6/DYNC1LI1/CDC42/ARL4C/RAB10/ARF3/RAB8A/RAB7A/RAB13	49
GO:0032561	guanyl ribonucleotide binding	49/1094	398/18367	1.11544055721991e-06	6.22678287530409e-05	SAMHD1/IFI44L/MX1/ARL5A/RAB32/RAP2B/GBP1/GNAI2/TUBA1A/GIMAP4/RHOA/GBP4/RHOQ/RAP1A/MX2/RHOG/GBP2/CIITA/RRAGD/GBP5/GIMAP1/GIMAP2/EHD4/GNA15/LRRK2/RRAS/RIT1/RAP2A/GNA13/RAB29/RAB8B/RALA/RAC1/ATL3/DAPK1/ARL8B/EIF2S3/RHOB/RAB5C/GNAQ/ARF6/DYNC1LI1/CDC42/ARL4C/RAB10/ARF3/RAB8A/RAB7A/RAB13	49
GO:0038187	pattern recognition receptor activity	10/1094	26/18367	1.1914300915694e-06	6.28148420499647e-05	LY96/CD14/CLEC7A/CD36/TLR7/MARCO/TLR2/TLR4/PTAFR/TLR8	10
GO:0035325	Toll-like receptor binding	7/1094	12/18367	1.5863858781454e-06	7.92357999136836e-05	LY96/CD36/SYK/TLR2/TLR1/UNC93B1/MYD88	7
GO:0001540	amyloid-beta binding	18/1094	84/18367	1.73517264488303e-06	8.04766500795891e-05	APOE/CD74/MSR1/TREM2/C1QA/CST3/ITGB2/SORL1/CD36/MARCO/TLR2/TLR4/PRNP/LILRB2/ITGAM/LRP1/PFDN5/PICALM	18
GO:0030695	GTPase regulator activity	56/1094	488/18367	1.86563361617593e-06	8.04766500795891e-05	RGS1/RGS10/ADAP2/CCDC88A/ARHGDIB/JUN/DOCK4/NCKAP1L/ALDH1A1/DOCK10/GPSM3/SIRPA/DOCK2/RASGEF1B/RAP1A/WAS/PREX1/RCBTB2/ARHGAP30/MYO9B/FGD4/CYTH1/RIN2/TAGAP/RIN3/CYTH4/ABR/TBC1D2/ARHGAP15/RGS18/LRRK2/ARHGAP4/ITSN2/DENND1B/ARHGEF2/ARHGAP18/GNA13/ARAP1/ACAP2/GIT2/LAMTOR4/NUCB1/IQGAP1/SMAP1/ARHGAP24/DENND5A/GNAQ/LAMTOR2/AKAP13/TBC1D9B/FNIP1/RGS2/RCC2/GDI2/RANBP2/ARHGDIA	56
GO:0060589	nucleoside-triphosphatase regulator activity	56/1094	488/18367	1.86563361617593e-06	8.04766500795891e-05	RGS1/RGS10/ADAP2/CCDC88A/ARHGDIB/JUN/DOCK4/NCKAP1L/ALDH1A1/DOCK10/GPSM3/SIRPA/DOCK2/RASGEF1B/RAP1A/WAS/PREX1/RCBTB2/ARHGAP30/MYO9B/FGD4/CYTH1/RIN2/TAGAP/RIN3/CYTH4/ABR/TBC1D2/ARHGAP15/RGS18/LRRK2/ARHGAP4/ITSN2/DENND1B/ARHGEF2/ARHGAP18/GNA13/ARAP1/ACAP2/GIT2/LAMTOR4/NUCB1/IQGAP1/SMAP1/ARHGAP24/DENND5A/GNAQ/LAMTOR2/AKAP13/TBC1D9B/FNIP1/RGS2/RCC2/GDI2/RANBP2/ARHGDIA	56
GO:0005126	cytokine receptor binding	37/1094	271/18367	2.05816618816469e-06	8.49217266334039e-05	CCL3/CCL3L3/CXCL16/TNFSF13B/PYCARD/STAT1/CCDC88A/IL18/GRB2/CKLF/IL13RA1/SDCBP/CCL4/SYK/JAK1/VEGFA/TNFSF12/TGFB1/ENG/TGFBR2/BID/TLR5/CCRL2/JAK2/CD300LF/IL6R/SH2B3/SPRED1/TNFSF10/ITGA5/MYD88/IL1B/STAT3/VEGFB/TGFBR1/ADAM17/PIK3R1	37
GO:0003925	G protein activity	12/1094	40/18367	2.21201849162629e-06	8.74668978563897e-05	RAP2B/RHOA/RAP1A/RIT1/RAP2A/RALA/RAC1/ARL8B/RAB5C/CDC42/RAB10/RAB7A	12
GO:0008238	exopeptidase activity	20/1094	103/18367	2.41535613033986e-06	9.16869187077012e-05	CTSZ/CTSH/LTA4H/LAP3/TPP1/CTSC/CPM/CTSA/SCPEP1/ANPEP/VASH1/PEPD/QPCT/DPEP2/ERAP2/DPP7/RNPEPL1/PRCP/CPVL/CNDP2	20
GO:0005096	GTPase activator activity	53/1094	462/18367	3.54242306132992e-06	0.000129298441738542	RGS1/RGS10/ADAP2/CCDC88A/ARHGDIB/JUN/DOCK4/NCKAP1L/ALDH1A1/DOCK10/DOCK2/RASGEF1B/RAP1A/PREX1/RCBTB2/ARHGAP30/MYO9B/FGD4/CYTH1/RIN2/TAGAP/RIN3/CYTH4/ABR/TBC1D2/ARHGAP15/RGS18/LRRK2/ARHGAP4/ITSN2/DENND1B/ARHGEF2/ARHGAP18/GNA13/ARAP1/ACAP2/GIT2/LAMTOR4/NUCB1/IQGAP1/SMAP1/ARHGAP24/DENND5A/GNAQ/LAMTOR2/AKAP13/TBC1D9B/FNIP1/RGS2/RCC2/GDI2/RANBP2/ARHGDIA	53
GO:0044389	ubiquitin-like protein ligase binding	40/1094	316/18367	5.42106665703219e-06	0.000190540453982354	LAPTM5/TXNIP/CXCR4/ISG15/STAT1/JUN/HIF1A/ARRB2/LYN/RB1/UBE2L6/TMBIM6/HSPA1A/TNFRSF1B/TNFRSF14/JAK1/PARP9/STAT2/BID/DTX3L/PTK2B/GABARAP/CDKN1A/RALA/NFKBIA/SUMO3/CEBPB/PRKAR1A/HM13/RTN4/UBE2W/PRKACB/UBE2D1/APC/SKI/LTBR/PIAS1/CAMLG/SUMO2/PCBP2	40
GO:0008047	enzyme activator activity	20/1094	110/18367	6.91411521812541e-06	0.000234339119357179	APOE/APOC1/PSAP/CCL3/NUPR1/ALOX5AP/NCF2/CTSA/GMFG/NCF4/NCF1/BTK/DTX3L/LTC4S/MGST2/STX4/CALM3/KRTCAP2/DBNL/GM2A	20
GO:0019955	cytokine binding	23/1094	139/18367	7.60465547186824e-06	0.000248855794579412	CD74/CXCR4/ZFP36/CSF1R/A2M/CD36/GBP1/IFNGR1/CD4/IL13RA1/TNFRSF1B/TNFRSF14/IL10RA/CCR1/PLP2/ENG/TGFBR2/CCRL2/IL6R/ITGA4/IFNAR1/TGFBR1/TNFRSF1A	23
GO:0019864	IgG binding	6/1094	11/18367	1.57024261255888e-05	0.000480696851393023	FCGR3A/FCER1G/FCGRT/FCGR1A/FCGR2A/FCGR1B	6
GO:0042608	T cell receptor binding	6/1094	11/18367	1.57024261255888e-05	0.000480696851393023	HLA-DRA/HLA-DRB1/HLA-A/HLA-E/DOCK2/MR1	6
GO:0003953	NAD+ nucleosidase activity	9/1094	28/18367	2.24840626857909e-05	0.000666792984025485	TLR7/TLR2/TLR4/TLR1/PIK3AP1/TLR5/TLR8/MYD88/BST1	9
GO:0019865	immunoglobulin binding	8/1094	23/18367	3.38581372830295e-05	0.00097367794792712	FCGR3A/FCER1G/FCGRT/FCGR1A/LGALS3/FCGR2A/FCGR1B/LILRA2	8
GO:0038024	cargo receptor activity	15/1094	77/18367	4.13282240576895e-05	0.00115354366561022	MSR1/ITGB2/SORL1/CXCL16/OLR1/CD163/CD36/ASGR1/MARCO/STAB1/ITGAM/APOBR/SCARB2/LRP1/ABCA1	15
GO:0030228	lipoprotein particle receptor activity	7/1094	18/18367	4.64228867751949e-05	0.00125872341570457	SORL1/CXCL16/OLR1/CD36/STAB1/APOBR/LRP1	7
GO:0071813	lipoprotein particle binding	9/1094	31/18367	5.58083803200369e-05	0.00142363504871847	APOE/MSR1/TREM2/SORL1/CD36/LPL/PLTP/STAB1/ABCA1	9
GO:0071814	protein-lipid complex binding	9/1094	31/18367	5.58083803200369e-05	0.00142363504871847	APOE/MSR1/TREM2/SORL1/CD36/LPL/PLTP/STAB1/ABCA1	9
GO:0019207	kinase regulator activity	30/1094	233/18367	5.70054076409923e-05	0.00142363504871847	TREM2/LILRB4/NCKAP1L/TAOK3/GMFG/CIB1/MOB1A/KLF4/DAZAP2/SPRED1/PRKAG2/STK4/CDKN1A/ABI1/SOCS3/RGCC/PRKAR1A/CALM3/IQGAP1/PAK2/CAB39/APC/DNAJC3/TAOK1/CCNL1/CCNI/WNK1/PIK3R1/YWHAG/SOCS6	30
GO:0005543	phospholipid binding	49/1094	466/18367	7.95174173574334e-05	0.00190046089330841	APOE/APOC1/PSAP/CAPG/TREM2/SNX10/ADAP2/PPT1/CCDC88A/TPP1/PLA2G7/SDCBP/TWF2/CD300A/PLTP/AXL/PHLDA1/GGA2/PREX1/OSBPL1A/PTAFR/NCF4/NCF1/BTK/CD300LF/SGK3/MYO1G/PLEKHB2/SCARB2/DENND1B/OSBPL8/TLN1/ARAP1/GGA1/DAPP1/ABCG1/ABCA1/IQGAP1/SNX29/GSN/NUP62/FLII/PLA2G15/FCHO2/PICALM/CHMP3/APPL1/ZFYVE16/PFN1	49
GO:0140677	molecular function activator activity	22/1094	150/18367	8.01037257453492e-05	0.00190046089330841	APOE/APOC1/PSAP/CCL3/NUPR1/ALOX5AP/NCF2/CTSA/GMFG/NCF4/NCF1/BTK/DTX3L/ATP1B1/LTC4S/MGST2/STX4/CALM3/KRTCAP2/DBNL/GM2A/ATP1B3	22
GO:0035259	glucocorticoid receptor binding	6/1094	14/18367	8.73824886072717e-05	0.00200087951971878	YWHAH/NR4A2/NCOR2/STAT3/CEBPB/NR4A1	6
GO:0042287	MHC protein binding	10/1094	40/18367	8.85531505038869e-05	0.00200087951971878	CD74/CD81/HLA-E/CLEC7A/PILRA/CD4/LILRB1/TAPBP/TAP1/LILRB2	10
GO:0043548	phosphatidylinositol 3-kinase binding	9/1094	34/18367	0.000123514276449448	0.00270176307888969	HCST/AXL/CORO1A/PIK3AP1/JAK2/CALM3/GSN/PIK3R1/ATP1A1	9
GO:0005178	integrin binding	21/1094	144/18367	0.000125266149073916	0.00270176307888969	SPP1/GPNMB/CD9/CD81/ITGB2/ISG15/TGFBI/LCP1/TIMP2/LYN/SYK/FERMT3/ITGAX/ITGAM/ITGA4/TLN1/ADAM9/IL1B/ADAM17/ADAM10/TSPAN4	21
GO:0005041	low-density lipoprotein particle receptor activity	6/1094	15/18367	0.000138305961366321	0.00280963823257672	SORL1/CXCL16/OLR1/CD36/STAB1/LRP1	6
GO:0015485	cholesterol binding	11/1094	50/18367	0.000138661827050868	0.00280963823257672	NPC2/CD81/TSPO/SOAT1/OSBPL1A/NR1H3/SCARB2/OSBPL8/ABCG1/ABCA1/SCP2	11
GO:0001618	virus receptor activity	14/1094	76/18367	0.000139149627956908	0.00280963823257672	CD81/CXCR4/CD86/CD4/PLSCR1/CLEC5A/AXL/HSPA1A/TNFRSF14/ANPEP/SELPLG/ITGA5/SCARB2/LAMP1	14
GO:0070008	serine-type exopeptidase activity	5/1094	10/18367	0.000145486565760986	0.00287639064389948	TPP1/CTSA/SCPEP1/PRCP/CPVL	5
GO:0140272	exogenous protein binding	14/1094	77/18367	0.00016088771771229	0.0031159682471217	CD81/CXCR4/CD86/CD4/PLSCR1/CLEC5A/AXL/HSPA1A/TNFRSF14/ANPEP/SELPLG/ITGA5/SCARB2/LAMP1	14
GO:0004180	carboxypeptidase activity	10/1094	43/18367	0.000170177954392477	0.00322997757436922	CTSZ/LAP3/CPM/CTSA/SCPEP1/VASH1/PEPD/PRCP/CPVL/CNDP2	10
GO:0032934	sterol binding	12/1094	60/18367	0.00018366368068525	0.003417584960202	NPC2/CD81/TSPO/SOAT1/GPR183/OSBPL1A/NR1H3/SCARB2/OSBPL8/ABCG1/ABCA1/SCP2	12
GO:0043394	proteoglycan binding	9/1094	36/18367	0.000199066738331575	0.00356899907579354	APOE/GPNMB/CTSB/CTSS/PTPRC/LPL/SDCBP/HPSE/LRP1	9
GO:0031625	ubiquitin protein ligase binding	34/1094	297/18367	0.000199322393063285	0.00356899907579354	LAPTM5/TXNIP/CXCR4/ISG15/JUN/HIF1A/ARRB2/LYN/RB1/UBE2L6/TMBIM6/HSPA1A/TNFRSF1B/TNFRSF14/JAK1/BID/PTK2B/GABARAP/CDKN1A/RALA/NFKBIA/PRKAR1A/HM13/RTN4/UBE2W/PRKACB/UBE2D1/APC/SKI/LTBR/PIAS1/CAMLG/SUMO2/PCBP2	34
GO:0019887	protein kinase regulator activity	26/1094	204/18367	0.000204559414831363	0.00359494230879561	LILRB4/NCKAP1L/TAOK3/GMFG/CIB1/MOB1A/DAZAP2/SPRED1/PRKAG2/STK4/CDKN1A/ABI1/SOCS3/RGCC/PRKAR1A/CALM3/IQGAP1/PAK2/CAB39/APC/DNAJC3/TAOK1/CCNL1/CCNI/WNK1/YWHAG	26
GO:0001784	phosphotyrosine residue binding	10/1094	44/18367	0.000208599116135023	0.00359928293112977	GRB2/SAMSN1/SYK/HCK/PTPN6/SH3BP2/FGR/SOCS3/PIK3R1/PFN1	10
GO:0004715	non-membrane spanning protein tyrosine kinase activity	10/1094	45/18367	0.000254042494746306	0.0043051129913258	LYN/SYK/JAK1/HCK/CSK/BTK/JAK2/FGR/PTK2B/EIF2AK2	10
GO:0030169	low-density lipoprotein particle binding	6/1094	17/18367	0.000308484763181839	0.0050474489699925	MSR1/TREM2/SORL1/CD36/PLTP/STAB1	6
GO:0032393	MHC class I receptor activity	6/1094	17/18367	0.000308484763181839	0.0050474489699925	CTSH/LILRB1/LILRB3/LILRB2/LILRA2/MR1	6
GO:0001965	G-protein alpha-subunit binding	7/1094	24/18367	0.000368341878158722	0.00592468546394283	RGS1/RGS10/CCDC88A/RGS19/IGF2R/NUCB1/RGS2	7
GO:0045296	cadherin binding	36/1094	332/18367	0.000379105977094715	0.00599619287104807	CAPG/FXYD5/STAT1/FLNA/TWF2/HSPA1A/EFHD2/LASP1/EHD4/TBC1D2/VASP/TLN1/ARHGAP18/ABI1/PTPRJ/CAPZA1/SHTN1/LDHA/NUMB/IQGAP1/RTN4/PAK2/EIF2S3/CLIC1/PKM/LRRFIP1/PICALM/RAB10/DBNL/KTN1/FMNL2/KIF5B/PLEC/CAPZB/PFN1/S100A11	36
GO:0003725	double-stranded RNA binding	13/1094	74/18367	0.000387882425347392	0.00603443314187991	VIM/MTDH/MSN/TLR7/MBNL1/OAS1/OAS2/OAS3/TLR8/IFIH1/EIF2AK2/ADAR/LRRFIP1	13
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	33/1094	299/18367	0.000476880122812508	0.00729934252498501	IFI27/MTDH/FBP1/YWHAH/FOS/MEF2A/STAT1/SPI1/ID2/ACTB/JUN/HIF1A/RB1/NR4A2/KLF4/PARP9/LMO2/MDFIC/DTX3L/NCOR2/NOTCH2/JMJD1C/STAT3/NFKBIA/CEBPB/DDX5/CEBPA/BHLHE40/HCLS1/NR4A1/SPEN/CHD4/BHLHE41	33
GO:0001530	lipopolysaccharide binding	8/1094	33/18367	0.000562931650833025	0.00847971645461176	TREM2/LY96/CD14/TLR2/TLR4/P2RX7/PTAFR/NINJ1	8
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	10/1094	50/18367	0.000624049561417047	0.00925348490288715	TLR7/TLR2/TLR4/TLR1/PIK3AP1/TLR5/TLR8/MYD88/MBD4/BST1	10
GO:0019902	phosphatase binding	24/1094	196/18367	0.000635433706208562	0.00927733211064501	STAT1/LGALS3/CTSC/GRB2/LILRB4/PHACTR1/SYK/SIRPA/LILRB1/EIF4EBP1/JAK1/PPP1R18/LILRB2/CSK/C20orf27/SPRED1/CD33/STAT6/STAT3/IQGAP1/PPP1R15A/WNK1/BOD1L1/PIK3R1	24
GO:0035091	phosphatidylinositol binding	30/1094	271/18367	0.00080301789224896	0.0113791866168788	CAPG/SNX10/ADAP2/CCDC88A/SDCBP/TWF2/PHLDA1/GGA2/NCF4/NCF1/BTK/SGK3/MYO1G/PLEKHB2/DENND1B/OSBPL8/TLN1/ARAP1/GGA1/DAPP1/IQGAP1/SNX29/GSN/FLII/FCHO2/PICALM/CHMP3/APPL1/ZFYVE16/PFN1	30
GO:0004860	protein kinase inhibitor activity	12/1094	70/18367	0.000806898759216533	0.0113791866168788	LILRB4/TAOK3/GMFG/CIB1/SPRED1/PRKAG2/CDKN1A/SOCS3/PRKAR1A/DNAJC3/WNK1/YWHAG	12
GO:0005085	guanyl-nucleotide exchange factor activity	26/1094	223/18367	0.000815368482558228	0.0113791866168788	CCDC88A/DOCK4/DOCK10/DOCK2/RASGEF1B/RAP1A/PREX1/RCBTB2/FGD4/CYTH1/RIN2/TAGAP/RIN3/CYTH4/ABR/ITSN2/DENND1B/ARHGEF2/GNA13/LAMTOR4/NUCB1/DENND5A/LAMTOR2/AKAP13/FNIP1/RCC2	26
GO:0042288	MHC class I protein binding	6/1094	20/18367	0.000828073888064617	0.0113890162285989	HLA-E/PILRA/LILRB1/TAPBP/TAP1/LILRB2	6
GO:0015248	sterol transporter activity	8/1094	36/18367	0.0010466650862778	0.0141897880982519	APOE/NPC2/TSPO/PLTP/OSBPL1A/OSBPL8/ABCG1/ABCA1	8
GO:0140297	DNA-binding transcription factor binding	39/1094	394/18367	0.00130649534887398	0.0174628744518508	IFI27/MTDH/FBP1/YWHAH/FOS/MEF2A/STAT1/SPI1/ID2/ACTB/JUN/HIF1A/MEF2C/RB1/USF2/NR4A2/KLF4/PARP9/CIITA/LMO2/CXXC5/MDFIC/DTX3L/NCOR2/NOTCH2/JMJD1C/STAT3/NFKBIA/CEBPB/DDX5/CEBPA/BHLHE40/SKI/HCLS1/NR4A1/SPEN/PTMA/CHD4/BHLHE41	39
GO:0019210	kinase inhibitor activity	12/1094	74/18367	0.00133751355171268	0.0175402045477056	LILRB4/TAOK3/GMFG/CIB1/SPRED1/PRKAG2/CDKN1A/SOCS3/PRKAR1A/DNAJC3/WNK1/YWHAG	12
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	5/1094	15/18367	0.00134924650366966	0.0175402045477056	CYBA/CYBB/NCF2/NCF1/CYB5R4	5
GO:0004602	glutathione peroxidase activity	6/1094	22/18367	0.00143878454401685	0.0182054204302933	GPX1/ALOX5AP/MGST1/LTC4S/GPX4/MGST2	6
GO:0120020	cholesterol transfer activity	6/1094	22/18367	0.00143878454401685	0.0182054204302933	APOE/NPC2/TSPO/PLTP/ABCG1/ABCA1	6
GO:0019903	protein phosphatase binding	19/1094	150/18367	0.00150101772398202	0.0185321466048402	STAT1/LGALS3/GRB2/LILRB4/PHACTR1/SIRPA/LILRB1/EIF4EBP1/JAK1/LILRB2/CSK/C20orf27/CD33/STAT6/STAT3/IQGAP1/PPP1R15A/BOD1L1/PIK3R1	19
GO:1901981	phosphatidylinositol phosphate binding	21/1094	173/18367	0.00150366205329051	0.0185321466048402	CAPG/ADAP2/SDCBP/TWF2/PHLDA1/NCF4/BTK/MYO1G/PLEKHB2/DENND1B/OSBPL8/ARAP1/DAPP1/IQGAP1/GSN/FLII/FCHO2/PICALM/CHMP3/ZFYVE16/PFN1	21
GO:0045309	protein phosphorylated amino acid binding	10/1094	56/18367	0.00156506791415049	0.0190416596221643	GRB2/SAMSN1/SYK/HCK/PTPN6/SH3BP2/FGR/SOCS3/PIK3R1/PFN1	10
GO:0019829	ATPase-coupled cation transmembrane transporter activity	9/1094	47/18367	0.0015982407940352	0.0191991204245494	ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP1B1/ATP2C1/ATP6V0E1/ATP1B3/ATP1A1	9
GO:0030674	protein-macromolecule adaptor activity	31/1094	296/18367	0.00163823880250703	0.0194336077947396	ADAP2/GNB4/GRB2/AP1S2/LPL/SDCBP/TRIM22/CIB1/KLF4/PAG1/STX10/DOK2/APH1B/SH2B3/ATP1B1/LRRK2/STX6/ARPC4/ABI1/STAT3/STX4/STX12/IQGAP1/GNB1/SERINC1/NUP62/AKAP13/HERPUD1/STX7/ATP1B3/PIK3R1	31
GO:0019209	kinase activator activity	15/1094	107/18367	0.00166627210377878	0.0195221262529144	TREM2/NCKAP1L/MOB1A/DAZAP2/PRKAG2/STK4/CDKN1A/ABI1/RGCC/CALM3/IQGAP1/PAK2/CAB39/TAOK1/WNK1	15
GO:0070851	growth factor receptor binding	18/1094	141/18367	0.00180628437895911	0.0207655753666819	PYCARD/CCDC88A/GRB2/LYN/PLSCR1/SDCBP/HBEGF/VEGFA/TLR5/JAK2/CD300LF/IL6R/ITGA5/MYD88/PTPRJ/IL1B/VEGFB/ADAM17	18
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	8/1094	39/18367	0.00181616728707544	0.0207655753666819	ADAP2/BTK/MYO1G/PLEKHB2/ARAP1/DAPP1/IQGAP1/ZFYVE16	8
GO:0120015	sterol transfer activity	6/1094	23/18367	0.00184954933906542	0.0208955038425367	APOE/NPC2/TSPO/PLTP/ABCG1/ABCA1	6
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/1094	10/18367	0.00196692957133207	0.0219601901552251	CYBA/CYBB/NCF2/NCF1	4
GO:0042626	ATPase-coupled transmembrane transporter activity	15/1094	109/18367	0.0020089620022727	0.0221686620948465	ATP6V1F/ATP6V1B2/ATP6V0D1/TAPBP/TAP1/ATP6V1A/ABCC3/ATP1B1/ATP2C1/ABCG1/ABCA1/ATP6V0E1/CLCN7/ATP1B3/ATP1A1	15
GO:0051219	phosphoprotein binding	13/1094	88/18367	0.00206160800064749	0.0224881148576375	GRB2/LYN/RB1/SAMSN1/SYK/HCK/PTPN6/SH3BP2/FGR/SOCS3/IGF2R/PIK3R1/PFN1	13
GO:0004177	aminopeptidase activity	8/1094	40/18367	0.0021536086399298	0.02258752773884	CTSH/LTA4H/LAP3/ANPEP/PEPD/ERAP2/DPP7/RNPEPL1	8
GO:0042169	SH2 domain binding	8/1094	40/18367	0.0021536086399298	0.02258752773884	CCDC88A/SYK/LAT2/LILRB1/PAG1/PTPN6/JAK2/NUP62	8
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	8/1094	40/18367	0.0021536086399298	0.02258752773884	CTSH/PYCARD/NAIP/CASP1/RPS6KA1/RPS27L/RPS6KA3/XIAP	8
GO:0016763	pentosyltransferase activity	9/1094	49/18367	0.00216592731742301	0.02258752773884	TYMP/UPP1/PARP9/NAMPT/PARP12/PARP4/LACC1/PARP14/HPRT1	9
GO:0043178	alcohol binding	13/1094	89/18367	0.00228559052483369	0.0233442615269489	NPC2/CD81/TSPO/ADAP2/SOAT1/OSBPL1A/NR1H3/SCARB2/OSBPL8/RBP7/ABCG1/ABCA1/SCP2	13
GO:0016798	hydrolase activity, acting on glycosyl bonds	18/1094	144/18367	0.00228768843204031	0.0233442615269489	LYZ/TLR7/TLR2/TLR4/TLR1/PIK3AP1/HPSE/TLR5/GALC/TLR8/MYD88/MBD4/MAN1A1/BST1/HEXA/GAA/ACER3/GM2A	18
GO:0005496	steroid binding	14/1094	100/18367	0.0023746497541974	0.0239738576248227	NPC2/CD81/TSPO/SOAT1/GPR183/OSBPL1A/NR1H3/SCARB2/OSBPL8/ABCG1/ABCA1/NR3C1/SCP2/ATP1A1	14
GO:0034185	apolipoprotein binding	5/1094	17/18367	0.00251639818469787	0.0243679783395743	TREM2/LPL/LRP1/ABCA1/CANX	5
GO:0042625	ATPase-coupled ion transmembrane transporter activity	5/1094	17/18367	0.00251639818469787	0.0243679783395743	ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V0E1	5
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	5/1094	17/18367	0.00251639818469787	0.0243679783395743	ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V0E1	5
GO:0046961	proton-transporting ATPase activity, rotational mechanism	5/1094	17/18367	0.00251639818469787	0.0243679783395743	ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V0E1	5
GO:0030295	protein kinase activator activity	14/1094	101/18367	0.00260929748815416	0.0250123567298818	NCKAP1L/MOB1A/DAZAP2/PRKAG2/STK4/CDKN1A/ABI1/RGCC/CALM3/IQGAP1/PAK2/CAB39/TAOK1/WNK1	14
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	42/1094	450/18367	0.00266112104483998	0.0252540387155315	MAFB/FOS/MEF2A/LITAF/SPI1/KLF6/TFEC/JUN/JUNB/HIF1A/MEF2C/PLSCR1/NR4A2/ATF5/REL/KLF4/ELK3/MAF/RUNX1/PBX3/NFIC/MITF/NR1H3/FLI1/STAT6/ELF1/STAT3/ETV6/CEBPB/FOSB/CREBRF/IRF1/ZNF267/BACH1/CEBPA/NR4A1/KLF10/IRF2/NR3C1/ATF3/EGR1/CEBPD	42
GO:0061134	peptidase regulator activity	25/1094	230/18367	0.00269486861652437	0.025321092248333	C3/CSTB/TIMP1/CST3/CTSH/BST2/PYCARD/SERPINA1/CTSC/A2M/TIMP2/NAIP/CASP1/PRNP/CARD16/RPS6KA1/APH1B/CSTA/SERPINB8/SERPING1/RPS27L/RPS6KA3/ROCK1/XIAP/PSME2	25
GO:0019956	chemokine binding	7/1094	33/18367	0.00284338686049929	0.0264546483393512	CXCR4/ZFP36/A2M/CCR1/PLP2/CCRL2/ITGA4	7
GO:0051019	mitogen-activated protein kinase binding	6/1094	25/18367	0.00292995920368561	0.0268604147552993	DUSP1/ARRB2/PTAFR/MAPKAPK3/PTPRJ/IQGAP1	6
GO:0035591	signaling adaptor activity	12/1094	81/18367	0.00294360709647115	0.0268604147552993	GNB4/PAG1/DOK2/SH2B3/LRRK2/ABI1/STAT3/IQGAP1/GNB1/NUP62/AKAP13/PIK3R1	12
GO:0003823	antigen binding	20/1094	171/18367	0.00298612488181135	0.0269888810746569	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-A/HLA-B/HLA-C/HLA-E/HLA-F/SIRPA/CD48/TAPBP/TAP1/TGFB1/HLA-DRB5/ITGA4/LILRA2/TSPAN4	20
GO:0030246	carbohydrate binding	28/1094	271/18367	0.00324925357275694	0.0290900154768522	HLA-DRA/HLA-DRB1/LGALS1/FBP1/OLR1/CLEC2B/LGALS3/CLEC7A/LGALS9/CD302/GPCPD1/ASGR1/CLEC5A/CD72/CLEC12A/FUOM/CD69/ENG/SIGLEC1/LGALS2/SIGLEC7/CLEC4A/CD33/P4HA1/SLC2A3/IGF2R/CANX/GAA	28
GO:0001216	DNA-binding transcription activator activity	42/1094	456/18367	0.00338023823687133	0.0295980279888367	MAFB/FOS/MEF2A/LITAF/SPI1/KLF6/TFEC/JUN/JUNB/HIF1A/MEF2C/PLSCR1/NR4A2/ATF5/REL/KLF4/ELK3/MAF/RUNX1/PBX3/NFIC/MITF/NR1H3/FLI1/STAT6/ELF1/STAT3/ETV6/CEBPB/FOSB/CREBRF/IRF1/ZNF267/BACH1/CEBPA/NR4A1/KLF10/IRF2/NR3C1/ATF3/EGR1/CEBPD	42
GO:0008235	metalloexopeptidase activity	11/1094	72/18367	0.00339281332470276	0.0295980279888367	LTA4H/LAP3/CPM/ANPEP/VASH1/PEPD/QPCT/DPEP2/ERAP2/RNPEPL1/CNDP2	11
GO:0030291	protein serine/threonine kinase inhibitor activity	7/1094	34/18367	0.00339956275108872	0.0295980279888367	CIB1/SPRED1/PRKAG2/CDKN1A/PRKAR1A/WNK1/YWHAG	7
GO:0004875	complement receptor activity	4/1094	12/18367	0.00421217198677512	0.035374789517253	FPR3/C5AR1/C3AR1/FPR1	4
GO:0030955	potassium ion binding	4/1094	12/18367	0.00421217198677512	0.035374789517253	PDXK/ACAT1/PKM/ATP1A1	4
GO:0032396	inhibitory MHC class I receptor activity	4/1094	12/18367	0.00421217198677512	0.035374789517253	LILRB1/LILRB3/LILRB2/LILRA2	4
GO:0097677	STAT family protein binding	4/1094	12/18367	0.00421217198677512	0.035374789517253	SPI1/PARP9/DTX3L/CEBPA	4
GO:0070006	metalloaminopeptidase activity	6/1094	27/18367	0.00442322735886924	0.0368214277505869	LTA4H/LAP3/ANPEP/PEPD/ERAP2/RNPEPL1	6
GO:0060090	molecular adaptor activity	35/1094	369/18367	0.00448170581021709	0.0369838157730088	ADAP2/GNB4/GRB2/AP1S2/LPL/SDCBP/TRIM22/CIB1/KLF4/SCIMP/PAG1/STX10/DOK2/APH1B/SH2B3/ATP1B1/LRRK2/STX6/ITSN2/ARPC4/ABI1/STAT3/LAMTOR4/STX4/STX12/IQGAP1/GNB1/SERINC1/NUP62/LAMTOR2/AKAP13/HERPUD1/STX7/ATP1B3/PIK3R1	35
GO:0004674	protein serine/threonine kinase activity	36/1094	386/18367	0.00521335782676335	0.0426506601517105	CCL3/SGK1/MAP3K2/BMP2K/TAOK3/SYK/STK38L/ENG/TGFBR2/IRAK1/CAMK1D/FAM20C/RPS6KA1/PLK3/SGK3/IRAK3/LRRK2/MAPKAPK3/PRKAG2/STK4/PTK2B/MAP3K8/PRKX/EIF2AK2/DAPK1/ATM/RPS6KA3/TGFBR1/PAK2/PRKACB/ROCK1/PAK1/UHMK1/AKAP13/TAOK1/WNK1	36
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5/1094	20/18367	0.00543234264623605	0.0436889251803221	ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V0E1	5
GO:0016505	peptidase activator activity involved in apoptotic process	5/1094	20/18367	0.00543234264623605	0.0436889251803221	CTSH/PYCARD/CTSC/CASP1/RPS27L	5
GO:0044325	transmembrane transporter binding	16/1094	133/18367	0.00567744148294523	0.0452764030866809	TSPO/YWHAH/PYCARD/SLC8A1/ID2/LYN/FLNA/CIB1/PRNP/KCNAB2/KCNE3/LRRK2/GRINA/CALM3/HERPUD1/S100A10	16
GO:0008035	high-density lipoprotein particle binding	4/1094	13/18367	0.00580020685870207	0.0458699692409022	TREM2/CD36/PLTP/ABCA1	4
GO:0005044	scavenger receptor activity	8/1094	47/18367	0.00609649102848569	0.0478146279837431	MSR1/CXCL16/CD163/CD36/MARCO/STAB1/SCARB2/LRP1	8
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	6/1094	29/18367	0.00641292902344842	0.0498841774037094	PLEK/ADAP2/NCF1/PLEKHA2/MYO1G/DAPP1	6
GO:0002020	protease binding	16/1094	135/18367	0.00655026947816322	0.0505382580063162	PSAP/CSTB/TIMP1/CST3/PYCARD/SERPINA1/A2M/TIMP2/MBP/PRNP/CARD16/CSTA/TNFAIP3/LRP1/CHMP3/FLOT1	16
GO:0046332	SMAD binding	11/1094	79/18367	0.00695688592347332	0.053242618882066	FOS/MEF2A/SKIL/JUN/FLNA/ZMIZ1/TGFBR2/RGCC/DDX5/TGFBR1/SKI	11
GO:0005172	vascular endothelial growth factor receptor binding	4/1094	14/18367	0.0077420497396888	0.0587776416237173	CCDC88A/VEGFA/ITGA5/VEGFB	4
GO:0005200	structural constituent of cytoskeleton	13/1094	103/18367	0.00810663941746826	0.0610571492633125	HLA-DRB1/VIM/ACTB/MSN/ACTR2/TUBA1A/ACTR3/ARPC3/TLN1/ARPC4/ARPC1B/ARPC5/PLEC	13
GO:0001786	phosphatidylserine binding	9/1094	60/18367	0.00869638565063076	0.0649832282082566	TREM2/CD300A/AXL/CD300LF/SCARB2/OSBPL8/TLN1/FCHO2/APPL1	9
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	11/1094	82/18367	0.00917519780385085	0.068025489967613	CAPG/ADAP2/SDCBP/TWF2/MYO1G/GSN/FLII/FCHO2/PICALM/CHMP3/PFN1	11
GO:0031072	heat shock protein binding	15/1094	129/18367	0.00984462220869456	0.0724228408996212	ITGB2/ZFP36/HIF1A/GBP1/HSPA1A/AHR/ITGAM/IRAK1/FKBP5/SPN/NUP62/BAX/NR3C1/ARHGDIA/KPNB1	15
GO:0005161	platelet-derived growth factor receptor binding	4/1094	15/18367	0.0100667054618776	0.0734869498717063	LYN/VEGFA/ITGA5/PTPRJ	4
GO:0019199	transmembrane receptor protein kinase activity	16/1094	143/18367	0.0111798558494298	0.0809899481000677	CSF1R/LYN/SYK/AXL/JAK1/HCK/ENG/TGFBR2/CSK/BTK/JAK2/FGR/PTK2B/EIF2AK2/IGF2R/TGFBR1	16
GO:0061135	endopeptidase regulator activity	20/1094	194/18367	0.0119060938522632	0.0855975989833165	C3/CSTB/TIMP1/CST3/BST2/SERPINA1/A2M/TIMP2/NAIP/PRNP/CARD16/RPS6KA1/APH1B/CSTA/SERPINB8/SERPING1/RPS6KA3/ROCK1/XIAP/PSME2	20
GO:0004896	cytokine receptor activity	12/1094	97/18367	0.0124768884407412	0.0874005028417648	CD74/CXCR4/CD44/IFNGR2/IFNGR1/CD4/IL13RA1/IL10RA/CCR1/CCRL2/IL6R/IFNAR1	12
GO:0005092	GDP-dissociation inhibitor activity	4/1094	16/18367	0.0127999366544194	0.0874005028417648	CCDC88A/ARHGDIB/GDI2/ARHGDIA	4
GO:0016004	phospholipase activator activity	4/1094	16/18367	0.0127999366544194	0.0874005028417648	CCL3/BTK/STX4/GM2A	4
GO:0050135	NAD(P)+ nucleosidase activity	4/1094	16/18367	0.0127999366544194	0.0874005028417648	TLR2/TLR4/TLR1/BST1	4
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	4/1094	16/18367	0.0127999366544194	0.0874005028417648	TLR2/TLR4/TLR1/BST1	4
GO:1990404	protein ADP-ribosylase activity	4/1094	16/18367	0.0127999366544194	0.0874005028417648	PARP9/PARP12/PARP4/PARP14	4
GO:0016504	peptidase activator activity	7/1094	43/18367	0.0128015488883091	0.0874005028417648	CTSH/PYCARD/CTSC/CASP1/APH1B/RPS27L/PSME2	7
GO:0016209	antioxidant activity	11/1094	86/18367	0.0129376846178156	0.0876990193021928	APOE/GPX1/SOD2/ALOX5AP/MGST1/PTGS1/GLRX/LTC4S/GPX4/MGST2/GSTO1	11
GO:0046982	protein heterodimerization activity	30/1094	328/18367	0.0130728558823153	0.0879868101582783	CYBA/YWHAH/MEF2A/CYBB/HIF1A/MEF2C/BCL2A1/USF2/SDCBP/NR4A2/AHR/TLR4/RRAGD/IRAK1/ATP1B1/IRAK3/MCL1/ABCG1/DRAP1/CEBPB/MAX/BHLHE40/HEXA/NR4A1/BAX/ATF3/MICU1/PIK3R1/ATP1A1/BHLHE41	30
GO:0051879	Hsp90 protein binding	7/1094	44/18367	0.0144626661065272	0.0966554234865797	HIF1A/GBP1/AHR/NUP62/NR3C1/ARHGDIA/KPNB1	7
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	8/1094	55/18367	0.0155542130741403	0.103060769511583	GPX1/ALOX5AP/MGST1/PTGS1/LTC4S/GPX4/MGST2/SESN3	8
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	4/1094	17/18367	0.0159641023374107	0.103060769511583	CTSH/PYCARD/CASP1/RPS27L	4
GO:0017081	chloride channel regulator activity	4/1094	17/18367	0.0159641023374107	0.103060769511583	SGK1/SGK3/STX7/WNK1	4
GO:0031420	alkali metal ion binding	4/1094	17/18367	0.0159641023374107	0.103060769511583	PDXK/ACAT1/PKM/ATP1A1	4
GO:0043395	heparan sulfate proteoglycan binding	4/1094	17/18367	0.0159641023374107	0.103060769511583	APOE/PTPRC/LPL/LRP1	4
GO:0004364	glutathione transferase activity	5/1094	26/18367	0.0171511411932085	0.109001048590417	ALOX5AP/MGST1/LTC4S/MGST2/GSTO1	5
GO:0004869	cysteine-type endopeptidase inhibitor activity	8/1094	56/18367	0.0172288274905822	0.109001048590417	CSTB/CST3/NAIP/CARD16/RPS6KA1/CSTA/RPS6KA3/XIAP	8
GO:0050840	extracellular matrix binding	8/1094	56/18367	0.0172288274905822	0.109001048590417	SPP1/LGALS1/CTSS/TGFBI/LGALS3/VEGFA/PLEKHA2/ADAM9	8
GO:0004690	cyclic nucleotide-dependent protein kinase activity	3/1094	10/18367	0.0184398149332259	0.110755597288806	PRKX/PRKACB/AKAP13	3
GO:0005031	tumor necrosis factor-activated receptor activity	3/1094	10/18367	0.0184398149332259	0.110755597288806	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0005384	manganese ion transmembrane transporter activity	3/1094	10/18367	0.0184398149332259	0.110755597288806	SLC11A1/TRPM2/ATP2C1	3
GO:0005522	profilin binding	3/1094	10/18367	0.0184398149332259	0.110755597288806	WIPF1/RHOQ/VASP	3
GO:0008239	dipeptidyl-peptidase activity	3/1094	10/18367	0.0184398149332259	0.110755597288806	CTSC/DPP7/PRCP	3
GO:0016176	superoxide-generating NADPH oxidase activator activity	3/1094	10/18367	0.0184398149332259	0.110755597288806	NCF2/NCF4/NCF1	3
GO:0034713	type I transforming growth factor beta receptor binding	3/1094	10/18367	0.0184398149332259	0.110755597288806	TGFB1/ENG/TGFBR2	3
GO:0071723	lipopeptide binding	3/1094	10/18367	0.0184398149332259	0.110755597288806	CD14/TLR2/TLR1	3
GO:0060229	lipase activator activity	4/1094	18/18367	0.01957807467958	0.116852785351707	CCL3/BTK/STX4/GM2A	4
GO:0140678	molecular function inhibitor activity	14/1094	128/18367	0.0202470803278207	0.120090495194386	APOC1/GCHFR/TXNIP/ID2/TMBIM6/OAZ1/PARP9/DTX3L/LRRK2/FNIP2/SLC30A1/FNIP1/WNK1/RNH1	14
GO:0042056	chemoattractant activity	6/1094	37/18367	0.0209720821878837	0.122101263780991	GPNMB/CCL3/LGALS3/HGF/VEGFA/VEGFB	6
GO:0043531	ADP binding	6/1094	37/18367	0.0209720821878837	0.122101263780991	TAP1/MYO9B/PRKAG2/ABCG1/PGK1/ATP1A1	6
GO:0046915	transition metal ion transmembrane transporter activity	6/1094	37/18367	0.0209720821878837	0.122101263780991	SLC11A1/TRPM2/ATP2C1/SLC31A1/MCOLN1/SLC30A1	6
GO:0004866	endopeptidase inhibitor activity	18/1094	180/18367	0.0217344572720697	0.12576829238533	C3/CSTB/TIMP1/CST3/BST2/SERPINA1/A2M/TIMP2/NAIP/PRNP/CARD16/RPS6KA1/CSTA/SERPINB8/SERPING1/RPS6KA3/ROCK1/XIAP	18
GO:0072341	modified amino acid binding	11/1094	93/18367	0.0221888026986909	0.127193429665073	TREM2/CD300A/AXL/MGST1/CD300LF/SCARB2/OSBPL8/TLN1/MGST2/FCHO2/APPL1	11
GO:0004857	enzyme inhibitor activity	9/1094	70/18367	0.0226190261094141	0.127193429665073	APOC1/GCHFR/TXNIP/TMBIM6/OAZ1/PARP9/DTX3L/LRRK2/RNH1	9
GO:0015026	coreceptor activity	7/1094	48/18367	0.0226508847348759	0.127193429665073	CXCR4/LY96/CD86/CD4/ENG/ITGA4/LRP1	7
GO:0048020	CCR chemokine receptor binding	7/1094	48/18367	0.0226508847348759	0.127193429665073	CCL3/CCL3L3/STAT1/CCL4/JAK1/CCRL2/STAT3	7
GO:0120013	lipid transfer activity	7/1094	48/18367	0.0226508847348759	0.127193429665073	APOE/NPC2/TSPO/PLTP/OSBPL8/ABCG1/ABCA1	7
GO:0003785	actin monomer binding	5/1094	28/18367	0.0232379997280952	0.12821431245327	TMSB4X/TMSB10/TWF2/CORO1A/PFN1	5
GO:0043236	laminin binding	5/1094	28/18367	0.0232379997280952	0.12821431245327	LGALS1/CTSS/LGALS3/PLEKHA2/ADAM9	5
GO:0051861	glycolipid binding	5/1094	28/18367	0.0232379997280952	0.12821431245327	PSAP/TREM2/PPT1/TPP1/LYN	5
GO:0008199	ferric iron binding	3/1094	11/18367	0.0242500134676772	0.130757174891055	FTL/FTH1/ACP5	3
GO:0031996	thioesterase binding	3/1094	11/18367	0.0242500134676772	0.130757174891055	RAC1/ARF6/CDC42	3
GO:0043560	insulin receptor substrate binding	3/1094	11/18367	0.0242500134676772	0.130757174891055	GRB2/JAK2/PIK3R1	3
GO:0051400	BH domain binding	3/1094	11/18367	0.0242500134676772	0.130757174891055	BCL2A1/MCL1/BAX	3
GO:0042379	chemokine receptor binding	9/1094	72/18367	0.0266651090976057	0.14178390183907	CCL3/CCL3L3/CXCL16/STAT1/CKLF/CCL4/JAK1/CCRL2/STAT3	9
GO:0004033	aldo-keto reductase (NADP) activity	5/1094	29/18367	0.0267432227915633	0.14178390183907	KCNAB2/RDH11/AKR1A1/DHRS3/DHRS4	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	5/1094	29/18367	0.0267432227915633	0.14178390183907	DPYD/BLVRB/TBXAS1/SRD5A3/BLVRA	5
GO:0030159	signaling receptor complex adaptor activity	7/1094	50/18367	0.0277533188435446	0.146309045264146	GNB4/DOK2/SH2B3/LRRK2/GNB1/NUP62/PIK3R1	7
GO:0030506	ankyrin binding	4/1094	20/18367	0.0282134407622116	0.146309045264146	SLC8A1/PTPRC/ATP1A1/PLEC	4
GO:0031683	G-protein beta/gamma-subunit complex binding	4/1094	20/18367	0.0282134407622116	0.146309045264146	GNAI2/GNA15/GNA13/GNAQ	4
GO:0035014	phosphatidylinositol 3-kinase regulator activity	4/1094	20/18367	0.0282134407622116	0.146309045264146	KLF4/SOCS3/PIK3R1/SOCS6	4
GO:0001664	G protein-coupled receptor binding	26/1094	295/18367	0.0297887200346467	0.153638561483042	C3/CCL3/CCL3L3/CXCL16/STAT1/ARRB2/CKLF/GNAI2/FLNA/HOMER3/SDCBP/CCL4/MARCO/HSPA1A/FPR1/JAK1/PRNP/CCRL2/JAK2/GNA15/GNA13/ARAP1/RALA/STAT3/CALM3/GNAQ	26
GO:0030414	peptidase inhibitor activity	18/1094	187/18367	0.0304177795835811	0.153674868949133	C3/CSTB/TIMP1/CST3/BST2/SERPINA1/A2M/TIMP2/NAIP/PRNP/CARD16/RPS6KA1/CSTA/SERPINB8/SERPING1/RPS6KA3/ROCK1/XIAP	18
GO:0004601	peroxidase activity	7/1094	51/18367	0.0305750389694694	0.153674868949133	GPX1/ALOX5AP/MGST1/PTGS1/LTC4S/GPX4/MGST2	7
GO:0000149	SNARE binding	12/1094	110/18367	0.0306512544605231	0.153674868949133	TNFAIP2/STX10/LRRK2/STX6/STXBP2/DAPK1/ABCA1/STX4/STX12/TMED10/PICALM/STX7	12
GO:0005024	transforming growth factor beta-activated receptor activity	3/1094	12/18367	0.0309292939613113	0.153674868949133	ENG/TGFBR2/TGFBR1	3
GO:0008429	phosphatidylethanolamine binding	3/1094	12/18367	0.0309292939613113	0.153674868949133	TREM2/CD300A/PLTP	3
GO:0035256	G protein-coupled glutamate receptor binding	3/1094	12/18367	0.0309292939613113	0.153674868949133	HOMER3/PRNP/CALM3	3
GO:0043422	protein kinase B binding	3/1094	12/18367	0.0309292939613113	0.153674868949133	CCDC88A/ARRB2/APPL1	3
GO:0017022	myosin binding	9/1094	74/18367	0.0311964471897945	0.154194939495391	CXCR4/PYCARD/RHOA/AXL/CORO1A/RALA/GSN/RAB10/RAB8A	9
GO:0001848	complement binding	4/1094	21/18367	0.0332552448101553	0.160971860210344	ITGB2/C5AR1/ITGAM/VSIG4	4
GO:0015662	P-type ion transporter activity	4/1094	21/18367	0.0332552448101553	0.160971860210344	ATP1B1/ATP2C1/ATP1B3/ATP1A1	4
GO:0140358	P-type transmembrane transporter activity	4/1094	21/18367	0.0332552448101553	0.160971860210344	ATP1B1/ATP2C1/ATP1B3/ATP1A1	4
GO:0008022	protein C-terminus binding	18/1094	189/18367	0.0333175688479335	0.160971860210344	NCF2/SDCBP/CIB1/CORO1A/PABPC1/CIITA/ATXN1/CSK/JAK2/ATP1B1/PTK2B/ERCC1/MIF4GD/TNFAIP3/KPNA3/FOXN3/PIAS1/DBNL	18
GO:0004714	transmembrane receptor protein tyrosine kinase activity	13/1094	124/18367	0.03341565485926	0.160971860210344	CSF1R/LYN/SYK/AXL/JAK1/HCK/CSK/BTK/JAK2/FGR/PTK2B/EIF2AK2/IGF2R	13
GO:0000146	microfilament motor activity	5/1094	31/18367	0.0347187353477612	0.164740399225127	MYO5A/MYO9B/MYO1F/MYO1G/MYL6	5
GO:0008157	protein phosphatase 1 binding	5/1094	31/18367	0.0347187353477612	0.164740399225127	PHACTR1/LILRB1/LILRB2/C20orf27/PPP1R15A	5
GO:0031210	phosphatidylcholine binding	5/1094	31/18367	0.0347187353477612	0.164740399225127	APOC1/PLTP/SCARB2/ABCA1/CHMP3	5
GO:0001046	core promoter sequence-specific DNA binding	6/1094	42/18367	0.0368742562358053	0.173235985979105	FOS/STAT1/DRAP1/CEBPB/KLF10/NR3C1	6
GO:0015036	disulfide oxidoreductase activity	6/1094	42/18367	0.0368742562358053	0.173235985979105	STAB1/GLRX/SCO2/ERO1A/PGK1/GSTO1	6
GO:0005035	death receptor activity	3/1094	13/18367	0.038468020092094	0.174453514678332	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0008494	translation activator activity	3/1094	13/18367	0.038468020092094	0.174453514678332	PABPC1/MIF4GD/RPS27L	3
GO:0031386	protein tag	3/1094	13/18367	0.038468020092094	0.174453514678332	ISG15/SUMO3/SUMO2	3
GO:0034236	protein kinase A catalytic subunit binding	3/1094	13/18367	0.038468020092094	0.174453514678332	CSK/PRKAR1A/PJA2	3
GO:0052650	NADP-retinol dehydrogenase activity	3/1094	13/18367	0.038468020092094	0.174453514678332	RDH11/DHRS3/DHRS4	3
GO:0030145	manganese ion binding	8/1094	65/18367	0.0384727883795011	0.174453514678332	GLUL/SOD2/LAP3/MGAT1/PEPD/FAM20C/PPM1M/TDP2	8
GO:0051117	ATPase binding	10/1094	89/18367	0.0386521591066178	0.174453514678332	SNX10/TCIRG1/ATP1B1/ATP6V0A1/ATOX1/RALA/RAC1/ABCA1/ATP1B3/SDF2L1	10
GO:0008106	alcohol dehydrogenase (NADP+) activity	4/1094	22/18367	0.0387878731265839	0.174453514678332	RDH11/AKR1A1/DHRS3/DHRS4	4
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/1094	22/18367	0.0387878731265839	0.174453514678332	NAIP/RPS6KA1/RPS6KA3/XIAP	4
GO:0071889	14-3-3 protein binding	5/1094	32/18367	0.0392015508138955	0.175482413784844	ZFP36/HLA-F/ZFP36L1/ARRB2/DDIT4	5
GO:0005319	lipid transporter activity	15/1094	154/18367	0.0414790730244994	0.184805823005868	APOE/FABP5/NPC2/TSPO/CD36/SLCO2B1/PLSCR1/PLTP/OSBPL1A/ABCC3/OSBPL8/ABCG1/ABCA1/TMEM30A/GM2A	15
GO:0017171	serine hydrolase activity	18/1094	195/18367	0.0432396069499718	0.191749471941697	CTSS/CFD/CTSH/TPP1/CTSC/CTSA/SCPEP1/NCEH1/ST14/C2/PLAU/ADAM8/MMP2/DPP7/PRCP/CPVL/HTRA1/SEC11A	18
GO:0005080	protein kinase C binding	7/1094	55/18367	0.0437653806858086	0.192513514720119	MARCKS/PLEK/CCDC88A/FLNA/TWF2/ADAM9/YWHAG	7
GO:0016298	lipase activity	13/1094	129/18367	0.0438666231971632	0.192513514720119	LIPA/PLD3/HMOX1/PLA2G7/LPL/NCEH1/CCR1/ABHD2/PLBD2/ABHD12/DDHD1/PLA2G15/PLBD1	13
GO:0019239	deaminase activity	5/1094	33/18367	0.0440204770224086	0.192513514720119	GNPDA1/APOBEC3C/APOBEC3A/LACC1/ADAR	5
GO:0003950	NAD+ ADP-ribosyltransferase activity	4/1094	23/18367	0.0448134387767668	0.194191568032656	PARP9/PARP12/PARP4/PARP14	4
GO:0070412	R-SMAD binding	4/1094	23/18367	0.0448134387767668	0.194191568032656	FOS/JUN/RGCC/DDX5	4
GO:0004298	threonine-type endopeptidase activity	3/1094	14/18367	0.0468478301882045	0.200263922741469	PSMB9/PSMB8/PSMB10	3
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	3/1094	14/18367	0.0468478301882045	0.200263922741469	DOK2/SH2B3/PIK3R1	3
GO:0044548	S100 protein binding	3/1094	14/18367	0.0468478301882045	0.200263922741469	S100A6/IQGAP1/S100A11	3
GO:1990782	protein tyrosine kinase binding	11/1094	105/18367	0.0480188845166881	0.204349423346803	TREM2/DOCK4/CD4/ITGAX/SIRPA/DAZAP2/DOK2/SH2B3/DUSP3/PIK3R1/YWHAG	11
GO:0048156	tau protein binding	6/1094	45/18367	0.0493423693515254	0.209044234440168	APOE/LGMN/ACTB/ROCK1/PICALM/TAOK1	6
GO:0019957	C-C chemokine binding	4/1094	24/18367	0.0513310944782219	0.215511286725488	CXCR4/ZFP36/CCR1/CCRL2	4
GO:0050431	transforming growth factor beta binding	4/1094	24/18367	0.0513310944782219	0.215511286725488	CD36/ENG/TGFBR2/TGFBR1	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	7/1094	57/18367	0.0515501181103116	0.215511286725488	IFI30/STAB1/GLRX/SCO2/ERO1A/PGK1/GSTO1	7
GO:0051087	chaperone binding	11/1094	107/18367	0.053747051335045	0.222733413611169	HLA-B/GRN/CTSC/PRNP/SCARB2/FNIP2/DNAJC3/FNIP1/BAX/ATP1A1/SDF2L1	11
GO:1902936	phosphatidylinositol bisphosphate binding	11/1094	107/18367	0.053747051335045	0.222733413611169	CAPG/ADAP2/SDCBP/TWF2/MYO1G/GSN/FLII/FCHO2/PICALM/CHMP3/PFN1	11
GO:0001846	opsonin binding	3/1094	15/18367	0.0560431113697863	0.22535979953359	ITGB2/ITGAM/VSIG4	3
GO:0005545	1-phosphatidylinositol binding	3/1094	15/18367	0.0560431113697863	0.22535979953359	SNX10/PICALM/ZFYVE16	3
GO:0016805	dipeptidase activity	3/1094	15/18367	0.0560431113697863	0.22535979953359	PEPD/DPEP2/CNDP2	3
GO:0016846	carbon-sulfur lyase activity	3/1094	15/18367	0.0560431113697863	0.22535979953359	ALOX5AP/LTC4S/MGST2	3
GO:0048185	activin binding	3/1094	15/18367	0.0560431113697863	0.22535979953359	ENG/TGFBR2/TGFBR1	3
GO:0050998	nitric-oxide synthase binding	3/1094	15/18367	0.0560431113697863	0.22535979953359	CD74/ACTB/CALM3	3
GO:1904680	peptide transmembrane transporter activity	3/1094	15/18367	0.0560431113697863	0.22535979953359	SLC15A3/TAPBP/TAP1	3
GO:0005160	transforming growth factor beta receptor binding	4/1094	25/18367	0.0583372152291324	0.231640239549986	TGFB1/ENG/TGFBR2/TGFBR1	4
GO:0030247	polysaccharide binding	4/1094	25/18367	0.0583372152291324	0.231640239549986	HLA-DRA/HLA-DRB1/CLEC7A/GPCPD1	4
GO:0035035	histone acetyltransferase binding	4/1094	25/18367	0.0583372152291324	0.231640239549986	MEF2A/STAT1/CEBPB/EGR1	4
GO:0048029	monosaccharide binding	8/1094	71/18367	0.0596605941662708	0.235907932765796	FBP1/LGALS9/FUOM/ENG/CLEC4A/P4HA1/SLC2A3/IGF2R	8
GO:0005484	SNAP receptor activity	5/1094	36/18367	0.0605158126947582	0.237312009286469	STX10/STX6/STX4/STX12/STX7	5
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	5/1094	36/18367	0.0605158126947582	0.237312009286469	APOBEC3C/APOBEC3A/LACC1/MTHFD2/ADAR	5
GO:0004713	protein tyrosine kinase activity	13/1094	136/18367	0.062045095759328	0.242307801957211	CSF1R/LYN/SYK/AXL/JAK1/HCK/CSK/BTK/JAK2/FGR/PTK2B/EIF2AK2/IGF2R	13
GO:0008236	serine-type peptidase activity	17/1094	191/18367	0.0638647304050966	0.248349741219392	CTSS/CFD/CTSH/TPP1/CTSC/CTSA/SCPEP1/ST14/C2/PLAU/ADAM8/MMP2/DPP7/PRCP/CPVL/HTRA1/SEC11A	17
GO:0070888	E-box binding	6/1094	48/18367	0.0641155812420981	0.248349741219392	HIF1A/AHR/MITF/MAX/BHLHE40/BHLHE41	6
GO:0005159	insulin-like growth factor receptor binding	3/1094	16/18367	0.0660223055348709	0.25062067181037	YWHAH/PIK3R1/YWHAG	3
GO:0005521	lamin binding	3/1094	16/18367	0.0660223055348709	0.25062067181037	IFI27/PRNP/BNIP3L	3
GO:0008191	metalloendopeptidase inhibitor activity	3/1094	16/18367	0.0660223055348709	0.25062067181037	TIMP1/BST2/TIMP2	3
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	3/1094	16/18367	0.0660223055348709	0.25062067181037	SOCS3/PIK3R1/SOCS6	3
GO:0050700	CARD domain binding	3/1094	16/18367	0.0660223055348709	0.25062067181037	CASP1/CARD16/CARD19	3
GO:0015035	protein-disulfide reductase activity	5/1094	37/18367	0.0666945205864573	0.25216374516553	STAB1/GLRX/SCO2/ERO1A/PGK1	5
GO:0032813	tumor necrosis factor receptor superfamily binding	6/1094	49/18367	0.0695577249473827	0.259993672639415	TNFSF13B/STAT1/TNFSF12/BID/TNFSF10/MYD88	6
GO:0043539	protein serine/threonine kinase activator activity	6/1094	49/18367	0.0695577249473827	0.259993672639415	DAZAP2/STK4/CALM3/IQGAP1/CAB39/TAOK1	6
GO:0043621	protein self-association	7/1094	61/18367	0.0695873475768298	0.259993672639415	CTSC/ATXN1/RSAD2/ADAM8/MYD88/TNFAIP3/PLEC	7
GO:0019905	syntaxin binding	8/1094	74/18367	0.0725534703255125	0.270012718976123	STX10/LRRK2/STX6/STXBP2/DAPK1/ABCA1/TMED10/STX7	8
GO:0004683	calmodulin-dependent protein kinase activity	4/1094	27/18367	0.0737876346646151	0.270364730875366	CAMK1D/MAPKAPK3/PTK2B/DAPK1	4
GO:0008139	nuclear localization sequence binding	4/1094	27/18367	0.0737876346646151	0.270364730875366	NUP214/KPNA3/NFKBIA/KPNB1	4
GO:0022884	macromolecule transmembrane transporter activity	4/1094	27/18367	0.0737876346646151	0.270364730875366	SLC15A3/MCL1/ABCA1/TMED10	4
GO:0043425	bHLH transcription factor binding	4/1094	27/18367	0.0737876346646151	0.270364730875366	USF2/LMO2/BHLHE40/BHLHE41	4
GO:1990841	promoter-specific chromatin binding	7/1094	62/18367	0.0746166050586894	0.272350608464216	STAT1/KLF4/PRDM1/ERCC1/DDX5/USP3/EGR1	7
GO:0042826	histone deacetylase binding	12/1094	127/18367	0.0760263259129993	0.275889625497691	MEF2A/SPI1/HIF1A/MEF2C/HSPA1A/KLF4/PRDM1/NCOR2/RAC1/CEBPB/CHD4/BHLHE41	12
GO:0005149	interleukin-1 receptor binding	3/1094	17/18367	0.0767490633628981	0.275889625497691	TLR5/MYD88/IL1B	3
GO:0008525	phosphatidylcholine transporter activity	3/1094	17/18367	0.0767490633628981	0.275889625497691	PLTP/ABCG1/ABCA1	3
GO:0016290	palmitoyl-CoA hydrolase activity	3/1094	17/18367	0.0767490633628981	0.275889625497691	PPT1/ACAA2/ACOT9	3
GO:0005504	fatty acid binding	5/1094	39/18367	0.0800605549681088	0.285629573927576	APOC1/FABP5/ALOX5AP/SCP2/ARHGDIA	5
GO:0050997	quaternary ammonium group binding	5/1094	39/18367	0.0800605549681088	0.285629573927576	APOC1/PLTP/SCARB2/ABCA1/CHMP3	5
GO:0001968	fibronectin binding	4/1094	28/18367	0.0822125738207018	0.291147588163525	CTSS/VEGFA/PLEKHA2/ITGA4	4
GO:0004725	protein tyrosine phosphatase activity	10/1094	102/18367	0.0822208152031872	0.291147588163525	DUSP1/PTPRC/DUSP23/PTPN6/DUSP2/PTPN18/PTPRJ/MTMR6/PTP4A2/DUSP3	10
GO:0004879	nuclear receptor activity	6/1094	52/18367	0.0874290840079759	0.307297039716923	NR4A2/AHR/NR1H3/STAT3/NR4A1/NR3C1	6
GO:0098531	ligand-activated transcription factor activity	6/1094	52/18367	0.0874290840079759	0.307297039716923	NR4A2/AHR/NR1H3/STAT3/NR4A1/NR3C1	6
GO:0031435	mitogen-activated protein kinase kinase kinase binding	3/1094	18/18367	0.0881832610995617	0.307668804351044	DAZAP2/TGFBR2/CDC42	3
GO:0033549	MAP kinase phosphatase activity	3/1094	18/18367	0.0881832610995617	0.307668804351044	DUSP1/DUSP2/DUSP3	3
GO:0106310	protein serine kinase activity	28/1094	360/18367	0.0901517235042812	0.31338456265774	SGK1/MAP3K2/BMP2K/TAOK3/CIITA/STK38L/IRAK1/CAMK1D/FAM20C/RPS6KA1/PLK3/SGK3/LRRK2/MAPKAPK3/STK4/MAP3K8/PRKX/EIF2AK2/DAPK1/ATM/RPS6KA3/PAK2/PRKACB/ROCK1/PAK1/UHMK1/TAOK1/WNK1	28
GO:0004620	phospholipase activity	10/1094	104/18367	0.0908460662406749	0.31433526842222	PLD3/HMOX1/PLA2G7/LPL/CCR1/PLBD2/ABHD12/DDHD1/PLA2G15/PLBD1	10
GO:0046625	sphingolipid binding	4/1094	29/18367	0.0910876699853639	0.31433526842222	PSAP/LYN/PLTP/CD300LF	4
GO:0030971	receptor tyrosine kinase binding	8/1094	78/18367	0.0921760682286445	0.316666238535796	DOCK4/ITGAX/DAZAP2/DOK2/SH2B3/DUSP3/PIK3R1/YWHAG	8
GO:0003714	transcription corepressor activity	16/1094	187/18367	0.0924305037665073	0.316666238535796	RB1/CREG1/TRIM22/HSPA1A/PARP9/NCOR2/SAP30/TDP2/PARP14/BTG2/DRAP1/TLE3/PFDN5/IRF2BP2/SPEN/PIAS1	16
GO:0048487	beta-tubulin binding	5/1094	41/18367	0.0947428594291503	0.323420768339078	GABARAP/ARL8B/TAOK1/RGS2/APPL1	5
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	3/1094	19/18367	0.100281893592164	0.338576472090462	ENG/TGFBR2/TGFBR1	3
GO:0070566	adenylyltransferase activity	4/1094	30/18367	0.100398416272592	0.338576472090462	OAS1/OAS2/OAS3/PAPSS1	4
GO:0008374	O-acyltransferase activity	6/1094	54/18367	0.100609657670717	0.338576472090462	SOAT1/LPCAT2/AGPAT2/LPGAT1/CPT1A/PLA2G15	6
GO:0015459	potassium channel regulator activity	6/1094	54/18367	0.100609657670717	0.338576472090462	SGK1/FLNA/KCNAB2/KCNE3/SGK3/WNK1	6
GO:0019894	kinesin binding	5/1094	42/18367	0.102562940941764	0.34252667162769	ACTB/RAB29/SHTN1/NUP62/KTN1	5
GO:0008237	metallopeptidase activity	16/1094	190/18367	0.102615431568149	0.34252667162769	LTA4H/LAP3/CPM/ANPEP/VASH1/ADAM8/PEPD/QPCT/MMP2/DPEP2/ERAP2/RNPEPL1/ADAM9/ADAM17/ADAM10/CNDP2	16
GO:0097110	scaffold protein binding	7/1094	67/18367	0.102866281784923	0.34252667162769	VIM/PSAP/TREM2/CD163/LYN/SYK/TREM1	7
GO:0005125	cytokine activity	19/1094	235/18367	0.108961665848006	0.357760078288975	SPP1/TIMP1/CCL3/GRN/CCL3L3/CXCL16/TNFSF13B/IL18/CKLF/CCL4/CMTM3/VEGFA/TNFSF12/TGFB1/CMTM7/NAMPT/SECTM1/TNFSF10/IL1B	19
GO:0005164	tumor necrosis factor receptor binding	4/1094	31/18367	0.110128739372566	0.357760078288975	TNFSF13B/STAT1/TNFSF12/TNFSF10	4
GO:0016411	acylglycerol O-acyltransferase activity	4/1094	31/18367	0.110128739372566	0.357760078288975	LPCAT2/AGPAT2/LPGAT1/PLA2G15	4
GO:0140318	protein transporter activity	4/1094	31/18367	0.110128739372566	0.357760078288975	RHBDF2/MCL1/ABCA1/TMED10	4
GO:0000287	magnesium ion binding	18/1094	221/18367	0.110587324825431	0.357760078288975	GLUL/PLSCR1/NUDT3/STK38L/RPS6KA1/IRAK3/LRRK2/STK4/RAP2A/MAP3K8/TDP2/PDXK/HPRT1/MTHFD2/RPS6KA3/PRKACB/PKM/WNK1	18
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	12/1094	136/18367	0.111805759355751	0.357760078288975	ME2/HSD17B11/CYP27A1/KCNAB2/IMPDH1/RDH11/VKORC1/AKR1A1/DHRS3/LDHA/DHRS4/HSD17B4	12
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/1094	20/18367	0.112999855856273	0.357760078288975	FOS/STAT1/CEBPB	3
GO:0001091	RNA polymerase II general transcription initiation factor binding	3/1094	20/18367	0.112999855856273	0.357760078288975	AHR/ERCC1/DRAP1	3
GO:0016408	C-acyltransferase activity	3/1094	20/18367	0.112999855856273	0.357760078288975	ACAA2/ACAT1/SCP2	3
GO:0097001	ceramide binding	3/1094	20/18367	0.112999855856273	0.357760078288975	PSAP/PLTP/CD300LF	3
GO:0005518	collagen binding	7/1094	69/18367	0.115584397460387	0.357760078288975	CTSB/CTSS/CD44/TGFBI/CRTAP/ADAM9/PAK1	7
GO:0001094	TFIID-class transcription factor complex binding	2/1094	10/18367	0.116111806230774	0.357760078288975	AHR/ERCC1	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/1094	10/18367	0.116111806230774	0.357760078288975	DUSP1/DUSP2	2
GO:0015279	store-operated calcium channel activity	2/1094	10/18367	0.116111806230774	0.357760078288975	ORAI2/ORAI3	2
GO:0016595	glutamate binding	2/1094	10/18367	0.116111806230774	0.357760078288975	GLUL/SLC1A3	2
GO:0017002	activin-activated receptor activity	2/1094	10/18367	0.116111806230774	0.357760078288975	TGFBR2/TGFBR1	2
GO:0019869	chloride channel inhibitor activity	2/1094	10/18367	0.116111806230774	0.357760078288975	STX7/WNK1	2
GO:0030957	Tat protein binding	2/1094	10/18367	0.116111806230774	0.357760078288975	ACTB/MDFIC	2
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/1094	10/18367	0.116111806230774	0.357760078288975	PIK3AP1/PIK3R1	2
GO:0043208	glycosphingolipid binding	2/1094	10/18367	0.116111806230774	0.357760078288975	PSAP/LYN	2
GO:0047844	deoxycytidine deaminase activity	2/1094	10/18367	0.116111806230774	0.357760078288975	APOBEC3C/APOBEC3A	2
GO:0050786	RAGE receptor binding	2/1094	10/18367	0.116111806230774	0.357760078288975	S100A4/FPR1	2
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	2/1094	10/18367	0.116111806230774	0.357760078288975	LPL/PLA2G15	2
GO:0008375	acetylglucosaminyltransferase activity	5/1094	44/18367	0.119123259987403	0.365851047663576	MGAT4A/MGAT1/LFNG/HEXA/B3GNT2	5
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	11/1094	124/18367	0.120735579107815	0.369606659913925	ME2/HSD17B11/CYP27A1/KCNAB2/IMPDH1/RDH11/AKR1A1/DHRS3/LDHA/DHRS4/HSD17B4	11
GO:0005548	phospholipid transporter activity	6/1094	57/18367	0.122209695363527	0.372916401607676	PLSCR1/PLTP/OSBPL8/ABCG1/ABCA1/TMEM30A	6
GO:0015399	primary active transmembrane transporter activity	15/1094	181/18367	0.122607068265901	0.372929832642117	ATP6V1F/ATP6V1B2/ATP6V0D1/TAPBP/TAP1/ATP6V1A/ABCC3/ATP1B1/ATP2C1/ABCG1/ABCA1/ATP6V0E1/CLCN7/ATP1B3/ATP1A1	15
GO:0016829	lyase activity	16/1094	196/18367	0.124978787367401	0.378929294605955	RNASET2/SDS/ALOX5AP/ME2/TBXAS1/SDSL/RSAD2/RNASE1/LTC4S/MGST2/SGPL1/HACD4/BST1/ADCY7/NPL/HSD17B4	16
GO:0001614	purinergic nucleotide receptor activity	3/1094	21/18367	0.12629062436396	0.379271526966448	GPR34/P2RX7/PTAFR	3
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	3/1094	21/18367	0.12629062436396	0.379271526966448	LPCAT2/AGPAT2/LPGAT1	3
GO:0016502	nucleotide receptor activity	3/1094	21/18367	0.12629062436396	0.379271526966448	GPR34/P2RX7/PTAFR	3
GO:0008028	monocarboxylic acid transmembrane transporter activity	6/1094	58/18367	0.129878261759285	0.387592674243904	CD36/SLCO2B1/SLC16A3/ABCC3/MPC1/SLC6A6	6
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	6/1094	58/18367	0.129878261759285	0.387592674243904	ALOX5AP/MGST1/LTC4S/MGST2/MAT2A/GSTO1	6
GO:0005154	epidermal growth factor receptor binding	4/1094	33/18367	0.130777155964884	0.389051790002117	CCDC88A/GRB2/PLSCR1/HBEGF	4
GO:0019838	growth factor binding	12/1094	141/18367	0.135289274223784	0.392614350061076	DUSP1/A2M/CD36/SDCBP/IL10RA/ENG/TGFBR2/IL6R/RHBDF2/IGF2R/HTRA1/TGFBR1	12
GO:0000774	adenyl-nucleotide exchange factor activity	2/1094	11/18367	0.136525537955906	0.392614350061076	HSPH1/PFN1	2
GO:0005078	MAP-kinase scaffold activity	2/1094	11/18367	0.136525537955906	0.392614350061076	IQGAP1/AKAP13	2
GO:0008603	cAMP-dependent protein kinase regulator activity	2/1094	11/18367	0.136525537955906	0.392614350061076	PRKAG2/PRKAR1A	2
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	2/1094	11/18367	0.136525537955906	0.392614350061076	DSE/FUOM	2
GO:0043295	glutathione binding	2/1094	11/18367	0.136525537955906	0.392614350061076	MGST1/MGST2	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/1094	11/18367	0.136525537955906	0.392614350061076	GLRX/PGK1	2
GO:0047676	arachidonate-CoA ligase activity	2/1094	11/18367	0.136525537955906	0.392614350061076	ACSL1/ACSL4	2
GO:0052739	phosphatidylserine 1-acylhydrolase activity	2/1094	11/18367	0.136525537955906	0.392614350061076	LPL/PLA2G15	2
GO:0061665	SUMO ligase activity	2/1094	11/18367	0.136525537955906	0.392614350061076	PIAS1/RANBP2	2
GO:0070513	death domain binding	2/1094	11/18367	0.136525537955906	0.392614350061076	MCL1/BAX	2
GO:0000062	fatty-acyl-CoA binding	3/1094	22/18367	0.140106848243545	0.396899698457088	SOAT1/ACBD5/SCP2	3
GO:0008320	protein transmembrane transporter activity	3/1094	22/18367	0.140106848243545	0.396899698457088	MCL1/ABCA1/TMED10	3
GO:0017075	syntaxin-1 binding	3/1094	22/18367	0.140106848243545	0.396899698457088	LRRK2/STXBP2/DAPK1	3
GO:0030742	GTP-dependent protein binding	3/1094	22/18367	0.140106848243545	0.396899698457088	GCHFR/RAB32/CDC42	3
GO:0033691	sialic acid binding	3/1094	22/18367	0.140106848243545	0.396899698457088	ST8SIA4/SIGLEC7/CD33	3
GO:0033293	monocarboxylic acid binding	7/1094	73/18367	0.143329003988338	0.403617877700098	APOC1/FABP5/PSAP/ALOX5AP/IGF2R/SCP2/ARHGDIA	7
GO:0140104	molecular carrier activity	7/1094	73/18367	0.143329003988338	0.403617877700098	NUP214/SCO2/ATOX1/KPNA3/EMC3/OXA1L/KPNB1	7
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	5/1094	47/18367	0.146126392251734	0.40906768804394	DUSP1/DUSP23/DUSP2/PTP4A2/DUSP3	5
GO:0035254	glutamate receptor binding	5/1094	47/18367	0.146126392251734	0.40906768804394	HOMER3/PRNP/CALM3/CANX/FLOT1	5
GO:0015078	proton transmembrane transporter activity	11/1094	130/18367	0.152211161779143	0.422266328013603	ATP6V1F/ATP6V0B/SLC11A1/SLC15A3/ATP6V1B2/ATP6V0D1/TCIRG1/ATP6V1A/HVCN1/ATP6V0A1/ATP6V0E1	11
GO:0042887	amide transmembrane transporter activity	4/1094	35/18367	0.152880252542046	0.422266328013603	SLC15A3/TAPBP/TAP1/AQP9	4
GO:0016493	C-C chemokine receptor activity	3/1094	23/18367	0.154400859663562	0.422266328013603	CXCR4/CCR1/CCRL2	3
GO:0016849	phosphorus-oxygen lyase activity	3/1094	23/18367	0.154400859663562	0.422266328013603	RNASET2/BST1/ADCY7	3
GO:0042171	lysophosphatidic acid acyltransferase activity	3/1094	23/18367	0.154400859663562	0.422266328013603	LPCAT2/AGPAT2/LPGAT1	3
GO:0047617	acyl-CoA hydrolase activity	3/1094	23/18367	0.154400859663562	0.422266328013603	PPT1/ACAA2/ACOT9	3
GO:0071617	lysophospholipid acyltransferase activity	3/1094	23/18367	0.154400859663562	0.422266328013603	LPCAT2/AGPAT2/LPGAT1	3
GO:1901567	fatty acid derivative binding	3/1094	23/18367	0.154400859663562	0.422266328013603	SOAT1/ACBD5/SCP2	3
GO:0004126	cytidine deaminase activity	2/1094	12/18367	0.157644786754825	0.425013927927072	APOBEC3C/APOBEC3A	2
GO:0005165	neurotrophin receptor binding	2/1094	12/18367	0.157644786754825	0.425013927927072	GRB2/PIK3R1	2
GO:0017154	semaphorin receptor activity	2/1094	12/18367	0.157644786754825	0.425013927927072	PLXNC1/PLXND1	2
GO:0045295	gamma-catenin binding	2/1094	12/18367	0.157644786754825	0.425013927927072	PTPRJ/APC	2
GO:1900750	oligopeptide binding	2/1094	12/18367	0.157644786754825	0.425013927927072	MGST1/MGST2	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	23/1094	310/18367	0.163592336562619	0.439799227756163	ZEB2/IFI16/SPI1/SKIL/TFEC/JUN/IRF8/ELK3/PRDM1/TRPS1/JDP2/MITF/BCL6/ETV6/CEBPB/BACH1/MAX/BHLHE40/SKI/LRRFIP1/NR3C1/ATF3/BHLHE41	23
GO:0061631	ubiquitin conjugating enzyme activity	4/1094	36/18367	0.164425807522957	0.44079121847256	UBE2L6/UBE2W/UBE2D1/UBE2D3	4
GO:0008009	chemokine activity	5/1094	49/18367	0.165447170353106	0.441756171106871	CCL3/CCL3L3/CXCL16/CKLF/CCL4	5
GO:0031406	carboxylic acid binding	14/1094	176/18367	0.165716751226603	0.441756171106871	APOC1/FABP5/PSAP/GLUL/ALOX5AP/ST8SIA4/SIGLEC7/CD33/P4HA1/IGF2R/SESN3/SLC1A3/SCP2/ARHGDIA	14
GO:0019789	SUMO transferase activity	3/1094	24/18367	0.169125111832896	0.447074459970525	PIAS1/RANBP2/SUMO2	3
GO:0043274	phospholipase binding	3/1094	24/18367	0.169125111832896	0.447074459970525	SYK/WAS/BTK	3
GO:0070003	threonine-type peptidase activity	3/1094	24/18367	0.169125111832896	0.447074459970525	PSMB9/PSMB8/PSMB10	3
GO:0004197	cysteine-type endopeptidase activity	10/1094	119/18367	0.171677089650619	0.452559883551215	CTSD/CTSB/CTSZ/CTSS/CTSH/LGMN/PYCARD/CTSC/CASP1/CAPNS1	10
GO:0001217	DNA-binding transcription repressor activity	23/1094	313/18367	0.174914005300886	0.456215313687421	ZEB2/IFI16/SPI1/SKIL/TFEC/JUN/IRF8/ELK3/PRDM1/TRPS1/JDP2/MITF/BCL6/ETV6/CEBPB/BACH1/MAX/BHLHE40/SKI/LRRFIP1/NR3C1/ATF3/BHLHE41	23
GO:0140359	ABC-type transporter activity	5/1094	50/18367	0.175468153083482	0.456215313687421	TAPBP/TAP1/ABCC3/ABCG1/ABCA1	5
GO:0004000	adenosine deaminase activity	2/1094	13/18367	0.179313289784413	0.456215313687421	LACC1/ADAR	2
GO:0008179	adenylate cyclase binding	2/1094	13/18367	0.179313289784413	0.456215313687421	CAP1/CALM3	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/1094	13/18367	0.179313289784413	0.456215313687421	GLRX/PGK1	2
GO:0016840	carbon-nitrogen lyase activity	2/1094	13/18367	0.179313289784413	0.456215313687421	SDS/SDSL	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/1094	13/18367	0.179313289784413	0.456215313687421	DUSP1/DUSP2	2
GO:0031404	chloride ion binding	2/1094	13/18367	0.179313289784413	0.456215313687421	CTSC/NQO2	2
GO:0032036	myosin heavy chain binding	2/1094	13/18367	0.179313289784413	0.456215313687421	AXL/CORO1A	2
GO:0042301	phosphate ion binding	2/1094	13/18367	0.179313289784413	0.456215313687421	NCEH1/MTHFD2	2
GO:0060590	ATPase regulator activity	2/1094	13/18367	0.179313289784413	0.456215313687421	HSPH1/PFN1	2
GO:0061133	endopeptidase activator activity	2/1094	13/18367	0.179313289784413	0.456215313687421	APH1B/PSME2	2
GO:0072542	protein phosphatase activator activity	2/1094	13/18367	0.179313289784413	0.456215313687421	CALM3/PPP1R15A	2
GO:0008266	poly(U) RNA binding	3/1094	25/18367	0.184232552278864	0.463757804012312	PABPC1/ATXN1/PABPC4	3
GO:0016289	CoA hydrolase activity	3/1094	25/18367	0.184232552278864	0.463757804012312	PPT1/ACAA2/ACOT9	3
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/1094	25/18367	0.184232552278864	0.463757804012312	ZFP36L2/ZFP36/ZFP36L1	3
GO:0120227	acyl-CoA binding	3/1094	25/18367	0.184232552278864	0.463757804012312	SOAT1/ACBD5/SCP2	3
GO:0051018	protein kinase A binding	5/1094	51/18367	0.185712941749684	0.46624757068902	CSK/LRRK2/PRKAR1A/PJA2/AKAP13	5
GO:0015175	neutral amino acid transmembrane transporter activity	4/1094	38/18367	0.188396899195555	0.470496466675215	SLC38A6/SLC6A6/SFXN3/MFSD12	4
GO:0140303	intramembrane lipid transporter activity	4/1094	38/18367	0.188396899195555	0.470496466675215	PLSCR1/ABCG1/ABCA1/TMEM30A	4
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	8/1094	94/18367	0.196850403023227	0.490051108200534	LYZ/HPSE/GALC/MAN1A1/HEXA/GAA/ACER3/GM2A	8
GO:0001637	G protein-coupled chemoattractant receptor activity	3/1094	26/18367	0.199676938359598	0.490051108200534	CXCR4/CCR1/CCRL2	3
GO:0004950	chemokine receptor activity	3/1094	26/18367	0.199676938359598	0.490051108200534	CXCR4/CCR1/CCRL2	3
GO:0008198	ferrous iron binding	3/1094	26/18367	0.199676938359598	0.490051108200534	FTL/FTH1/ACP5	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/1094	39/18367	0.200778195678691	0.490051108200534	UBE2L6/UBE2W/UBE2D1/UBE2D3	4
GO:0008474	palmitoyl-(protein) hydrolase activity	2/1094	14/18367	0.201390866383781	0.490051108200534	PPT1/ABHD12	2
GO:0032977	membrane insertase activity	2/1094	14/18367	0.201390866383781	0.490051108200534	EMC3/OXA1L	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/1094	14/18367	0.201390866383781	0.490051108200534	HSD17B11/HSD17B4	2
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	2/1094	14/18367	0.201390866383781	0.490051108200534	GPR34/PTAFR	2
GO:0098599	palmitoyl hydrolase activity	2/1094	14/18367	0.201390866383781	0.490051108200534	PPT1/ABHD12	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	5/1094	53/18367	0.206822211943202	0.501980253539894	SLCO2B1/SLC16A3/AQP9/ABCC3/ABCG1	5
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	10/1094	125/18367	0.211240121121391	0.511395089143367	ASAH1/DDAH2/GLS/APOBEC3C/APOBEC3A/LACC1/MTHFD2/ADAR/NTAN1/ACER3	10
GO:0017080	sodium channel regulator activity	4/1094	40/18367	0.213393566759788	0.51398602755086	SGK1/FXYD5/YWHAH/SGK3	4
GO:0043014	alpha-tubulin binding	4/1094	40/18367	0.213393566759788	0.51398602755086	HSPH1/ARL8B/ARL4C/TAOK1	4
GO:0004709	MAP kinase kinase kinase activity	3/1094	27/18367	0.21541310132147	0.514929554544271	MAP3K2/LRRK2/MAP3K8	3
GO:0030507	spectrin binding	3/1094	27/18367	0.21541310132147	0.514929554544271	PTPRC/GBP1/GNB1	3
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	3/1094	27/18367	0.21541310132147	0.514929554544271	ABCG1/ABCA1/TMEM30A	3
GO:0005516	calmodulin binding	15/1094	201/18367	0.218714263892676	0.521507126718968	MARCKS/RGS1/SLC8A1/MBP/MYO5A/MYO9B/MYO1F/CAMK1D/MYO1G/MAPKAPK3/RIT1/DAPK1/DDX5/IQGAP1/RGS2	15
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/1094	15/18367	0.223752059462857	0.525595803045177	ALDH2/ALDH1A1	2
GO:0004467	long-chain fatty acid-CoA ligase activity	2/1094	15/18367	0.223752059462857	0.525595803045177	ACSL1/ACSL4	2
GO:0015929	hexosaminidase activity	2/1094	15/18367	0.223752059462857	0.525595803045177	HEXA/GM2A	2
GO:0032794	GTPase activating protein binding	2/1094	15/18367	0.223752059462857	0.525595803045177	FMNL1/FMNL3	2
GO:0047372	acylglycerol lipase activity	2/1094	15/18367	0.223752059462857	0.525595803045177	ABHD2/ABHD12	2
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	2/1094	15/18367	0.223752059462857	0.525595803045177	PYCARD/CASP1	2
GO:0030170	pyridoxal phosphate binding	5/1094	55/18367	0.228669232315506	0.535820003623247	SDS/SDSL/KYNU/PDXK/SGPL1	5
GO:0008187	poly-pyrimidine tract binding	3/1094	28/18367	0.231397164621563	0.538225267710448	PABPC1/ATXN1/PABPC4	3
GO:0046875	ephrin receptor binding	3/1094	28/18367	0.231397164621563	0.538225267710448	GRB2/LYN/SDCBP	3
GO:0070325	lipoprotein particle receptor binding	3/1094	28/18367	0.231397164621563	0.538225267710448	APOE/LRP1/PICALM	3
GO:0070279	vitamin B6 binding	5/1094	56/18367	0.239835642824247	0.55648905877802	SDS/SDSL/KYNU/PDXK/SGPL1	5
GO:0022853	active ion transmembrane transporter activity	19/1094	267/18367	0.242991251479844	0.558099284770847	ATP6V1F/SLC8A1/SLC11A1/SLCO2B1/SLC15A3/ATP6V1B2/ATP6V0D1/SLC4A7/ATP6V1A/ABCC3/SLC37A2/SLC6A6/ATP1B1/ATP2C1/ATP6V0E1/SLC1A3/CLCN7/ATP1B3/ATP1A1	19
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/1094	16/18367	0.24628488145257	0.558099284770847	ALDH2/ALDH1A1	2
GO:0005523	tropomyosin binding	2/1094	16/18367	0.24628488145257	0.558099284770847	PYCARD/S100A6	2
GO:0008970	phospholipase A1 activity	2/1094	16/18367	0.24628488145257	0.558099284770847	LPL/PLA2G15	2
GO:0016208	AMP binding	2/1094	16/18367	0.24628488145257	0.558099284770847	FBP1/PRKAG2	2
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	2/1094	16/18367	0.24628488145257	0.558099284770847	DNASE2/RNASE1	2
GO:0070492	oligosaccharide binding	2/1094	16/18367	0.24628488145257	0.558099284770847	LGALS1/LGALS9	2
GO:0004181	metallocarboxypeptidase activity	3/1094	29/18367	0.24758672169497	0.558099284770847	CPM/VASH1/PEPD	3
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3/1094	29/18367	0.24758672169497	0.558099284770847	IL4I1/BLVRB/MTHFD2	3
GO:0051059	NF-kappaB binding	3/1094	29/18367	0.24758672169497	0.558099284770847	MTDH/NOTCH2/NFKBIA	3
GO:0051787	misfolded protein binding	3/1094	29/18367	0.24758672169497	0.558099284770847	HSPA1A/DNAJC3/SDF2L1	3
GO:0070717	poly-purine tract binding	3/1094	29/18367	0.24758672169497	0.558099284770847	PABPC1/ATXN1/PABPC4	3
GO:0042562	hormone binding	7/1094	86/18367	0.251452798786114	0.565470867412375	TSPO/CTSH/ALDH1A1/ABHD2/NR3C1/PIK3R1/ATP1A1	7
GO:0016790	thiolester hydrolase activity	4/1094	43/18367	0.252421347885774	0.566306995611345	PPT1/ACAA2/ACOT9/ABHD12	4
GO:0030276	clathrin binding	6/1094	72/18367	0.257442789365481	0.576210394122267	AP1S2/LRRK2/LRP1/AP1B1/SMAP1/PICALM	6
GO:0003727	single-stranded RNA binding	7/1094	87/18367	0.260660008150719	0.582038465258901	TLR7/PABPC1/ATXN1/TLR8/IFIH1/PABPC4/CNBP	7
GO:0046943	carboxylic acid transmembrane transporter activity	12/1094	163/18367	0.265500367879816	0.584915892588417	SLC7A7/CD36/SLCO2B1/SLC16A3/SLC38A6/AQP9/ABCC3/MPC1/SLC6A6/SFXN3/MFSD12/SLC1A3	12
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/1094	17/18367	0.26888965719786	0.584915892588417	PTPRC/PTPN6	2
GO:0005324	long-chain fatty acid transporter activity	2/1094	17/18367	0.26888965719786	0.584915892588417	FABP5/CD36	2
GO:0008484	sulfuric ester hydrolase activity	2/1094	17/18367	0.26888965719786	0.584915892588417	IDS/GNS	2
GO:0015278	calcium-release channel activity	2/1094	17/18367	0.26888965719786	0.584915892588417	TRPM2/MCOLN1	2
GO:0016854	racemase and epimerase activity	2/1094	17/18367	0.26888965719786	0.584915892588417	DSE/FUOM	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/1094	17/18367	0.26888965719786	0.584915892588417	PTPRC/PTPN6	2
GO:0031489	myosin V binding	2/1094	17/18367	0.26888965719786	0.584915892588417	RAB10/RAB8A	2
GO:0046965	retinoid X receptor binding	2/1094	17/18367	0.26888965719786	0.584915892588417	NR4A2/NCOR2	2
GO:0050780	dopamine receptor binding	2/1094	17/18367	0.26888965719786	0.584915892588417	ARRB2/GNA13	2
GO:0070064	proline-rich region binding	2/1094	17/18367	0.26888965719786	0.584915892588417	CSK/PFN1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	7/1094	88/18367	0.269961181194654	0.584915892588417	CYBA/CYBB/NCF2/NCF1/NQO2/CYB5R4/DHRS4	7
GO:0048306	calcium-dependent protein binding	7/1094	88/18367	0.269961181194654	0.584915892588417	S100A4/A2M/S100A6/CALM3/DDX5/S100A11/S100A10	7
GO:0005342	organic acid transmembrane transporter activity	12/1094	164/18367	0.272265253780469	0.58856429575778	SLC7A7/CD36/SLCO2B1/SLC16A3/SLC38A6/AQP9/ABCC3/MPC1/SLC6A6/SFXN3/MFSD12/SLC1A3	12
GO:0043015	gamma-tubulin binding	3/1094	31/18367	0.280420860547346	0.603445343898937	LYN/BLOC1S2/PAK1	3
GO:0140142	nucleocytoplasmic carrier activity	3/1094	31/18367	0.280420860547346	0.603445343898937	NUP214/KPNA3/KPNB1	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	5/1094	60/18367	0.2858030548157	0.61363597063371	DPYD/BLVRB/TBXAS1/SRD5A3/BLVRA	5
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/1094	18/18367	0.291477956710147	0.617438796691807	HSD17B11/HSD17B4	2
GO:0042834	peptidoglycan binding	2/1094	18/18367	0.291477956710147	0.617438796691807	TREM2/TLR2	2
GO:0046624	sphingolipid transporter activity	2/1094	18/18367	0.291477956710147	0.617438796691807	PLTP/ABCA1	2
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/1094	18/18367	0.291477956710147	0.617438796691807	KCNAB2/AKR1A1	2
GO:0098641	cadherin binding involved in cell-cell adhesion	2/1094	18/18367	0.291477956710147	0.617438796691807	RAB10/S100A11	2
GO:0140597	protein carrier activity	2/1094	18/18367	0.291477956710147	0.617438796691807	EMC3/OXA1L	2
GO:0005539	glycosaminoglycan binding	16/1094	230/18367	0.296480959364532	0.623350024338363	APOE/GPNMB/TREM2/CD44/PTPRC/LPL/TLR2/HBEGF/PRNP/VEGFA/ENG/TGFBR2/STAB1/ADGRE2/GNS/VEGFB	16
GO:0015605	organophosphate ester transmembrane transporter activity	3/1094	32/18367	0.29698910182318	0.623350024338363	SLC25A24/SLC25A19/SLC37A2	3
GO:0050699	WW domain binding	3/1094	32/18367	0.29698910182318	0.623350024338363	LITAF/DAZAP2/TCEAL3	3
GO:0051721	protein phosphatase 2A binding	3/1094	32/18367	0.29698910182318	0.623350024338363	STAT1/EIF4EBP1/BOD1L1	3
GO:0005507	copper ion binding	5/1094	61/18367	0.297552751343813	0.623350024338363	HAMP/PRNP/SCO2/LACC1/ATOX1	5
GO:0019208	phosphatase regulator activity	8/1094	107/18367	0.305636200166986	0.638873907397511	ZEB2/LGALS3/BMP2K/PHACTR1/EIF2AK2/CALM3/PPP1R15A/BOD1L1	8
GO:0043130	ubiquitin binding	7/1094	92/18367	0.30796567199274	0.642328401584859	CXCR4/UBE2L6/GGA2/GGA1/TNFAIP3/TAB2/NUP62	7
GO:0008514	organic anion transmembrane transporter activity	13/1094	185/18367	0.309427191835833	0.64396141458817	CD36/SLCO2B1/SLC16A3/SLC25A24/SLC4A7/SLC38A6/SLC25A19/MPC1/SLC6A6/SFXN3/SLC2A3/MFSD12/SLC1A3	13
GO:0000339	RNA cap binding	2/1094	19/18367	0.313971611194615	0.649148276740065	CYFIP1/EIF4G3	2
GO:0004745	NAD-retinol dehydrogenase activity	2/1094	19/18367	0.313971611194615	0.649148276740065	RDH11/DHRS3	2
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	2/1094	19/18367	0.313971611194615	0.649148276740065	BLVRB/MTHFD2	2
GO:0099106	ion channel regulator activity	10/1094	139/18367	0.315275168093752	0.650426379393415	SGK1/FXYD5/YWHAH/FLNA/KCNAB2/KCNE3/SGK3/SLC30A1/STX7/WNK1	10
GO:0001221	transcription coregulator binding	6/1094	78/18367	0.320054143747689	0.658853324114006	STAT1/HIF1A/AHR/KLF4/LMO2/CHD4	6
GO:0045182	translation regulator activity	10/1094	140/18367	0.323155479204728	0.663797726764691	PABPC1/EIF4EBP1/CYFIP1/MIF4GD/RPS27L/EIF2AK2/EIF4G3/EIF2S3/EIF1/CNBP	10
GO:0016229	steroid dehydrogenase activity	3/1094	34/18367	0.330250938547596	0.676907431277903	HSD17B11/SRD5A3/HSD17B4	3
GO:0047485	protein N-terminus binding	8/1094	110/18367	0.332525809284247	0.679043434285886	ALOX5AP/SDCBP/HSPA1A/NCOR2/GLRX/ATM/CALM3/ARF6	8
GO:0009055	electron transfer activity	9/1094	126/18367	0.336280446042347	0.679043434285886	CYBA/ALDH2/CYBB/NCF2/ME2/NCF1/NQO2/AKR1A1/DHRS3	9
GO:0001972	retinoic acid binding	2/1094	20/18367	0.336301806232209	0.679043434285886	FABP5/IGF2R	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/1094	20/18367	0.336301806232209	0.679043434285886	CEPT1/GNPTG	2
GO:0019211	phosphatase activator activity	2/1094	20/18367	0.336301806232209	0.679043434285886	CALM3/PPP1R15A	2
GO:0030296	protein tyrosine kinase activator activity	2/1094	20/18367	0.336301806232209	0.679043434285886	ABI1/PAK2	2
GO:0061608	nuclear import signal receptor activity	2/1094	20/18367	0.336301806232209	0.679043434285886	KPNA3/KPNB1	2
GO:0042578	phosphoric ester hydrolase activity	24/1094	366/18367	0.342380684627193	0.687225927612329	ACP5/FBP1/SAMHD1/DUSP1/PLD3/HMOX1/PTPRC/GPCPD1/CCR1/DUSP23/PTPN6/PPM1M/INPP5D/LRRK2/DUSP2/PTPN18/TDP2/PTPRJ/MTMR6/PTP4A2/ACP2/DUSP3/GNB1/ATP1A1	24
GO:0004252	serine-type endopeptidase activity	12/1094	174/18367	0.342526726828906	0.687225927612329	CTSS/CFD/CTSH/TPP1/CTSC/ST14/C2/PLAU/ADAM8/MMP2/HTRA1/SEC11A	12
GO:0004721	phosphoprotein phosphatase activity	12/1094	174/18367	0.342526726828906	0.687225927612329	DUSP1/PTPRC/DUSP23/PTPN6/PPM1M/LRRK2/DUSP2/PTPN18/PTPRJ/MTMR6/PTP4A2/DUSP3	12
GO:0008234	cysteine-type peptidase activity	13/1094	190/18367	0.343573093778424	0.687871025307436	CTSD/CTSB/CTSZ/CTSS/CTSH/LGMN/PYCARD/CTSC/CASP1/OTUD1/CAPNS1/TNFAIP3/USP3	13
GO:0005048	signal sequence binding	4/1094	50/18367	0.347627597119096	0.694523346665309	NUP214/KPNA3/NFKBIA/KPNB1	4
GO:0016922	nuclear receptor binding	10/1094	144/18367	0.355045159182223	0.707852638789768	YWHAH/STAT1/HIF1A/NR4A2/NCOR2/JMJD1C/STAT3/CEBPB/DDX5/NR4A1	10
GO:0005123	death receptor binding	2/1094	21/18367	0.358408246428867	0.711567836529277	BID/MYD88	2
GO:0015125	bile acid transmembrane transporter activity	2/1094	21/18367	0.358408246428867	0.711567836529277	SLCO2B1/ABCC3	2
GO:0016247	channel regulator activity	10/1094	145/18367	0.363091252032504	0.718602836266555	SGK1/FXYD5/YWHAH/FLNA/KCNAB2/KCNE3/SGK3/SLC30A1/STX7/WNK1	10
GO:0097718	disordered domain specific binding	3/1094	36/18367	0.363466134254949	0.718602836266555	RB1/HSPA1A/CALM3	3
GO:0004722	protein serine/threonine phosphatase activity	7/1094	98/18367	0.366604496600158	0.723300763562474	DUSP1/DUSP23/PPM1M/LRRK2/DUSP2/MTMR6/DUSP3	7
GO:0016597	amino acid binding	4/1094	52/18367	0.375177475829847	0.737149947334419	GCHFR/GLUL/DDAH2/SLC1A3	4
GO:1901682	sulfur compound transmembrane transporter activity	4/1094	52/18367	0.375177475829847	0.737149947334419	SLC25A19/ABCC3/SLC6A6/MFSD12	4
GO:0052689	carboxylic ester hydrolase activity	10/1094	147/18367	0.379246214343335	0.737926847748019	LIPA/PLA2G7/LPL/NCEH1/ABHD2/AOAH/ACOT9/ABHD12/PLA2G15/PGLS	10
GO:0005537	mannose binding	2/1094	22/18367	0.380238386247398	0.737926847748019	CLEC4A/IGF2R	2
GO:0005540	hyaluronic acid binding	2/1094	22/18367	0.380238386247398	0.737926847748019	CD44/STAB1	2
GO:0009975	cyclase activity	2/1094	22/18367	0.380238386247398	0.737926847748019	BST1/ADCY7	2
GO:0015645	fatty acid ligase activity	2/1094	22/18367	0.380238386247398	0.737926847748019	ACSL1/ACSL4	2
GO:0050321	tau-protein kinase activity	2/1094	22/18367	0.380238386247398	0.737926847748019	ROCK1/TAOK1	2
GO:0015171	amino acid transmembrane transporter activity	6/1094	84/18367	0.384561534744143	0.744793666269779	SLC7A7/SLC38A6/SLC6A6/SFXN3/MFSD12/SLC1A3	6
GO:0015631	tubulin binding	24/1094	375/18367	0.387652246898251	0.749250473129207	CCDC88A/MX1/LYN/RMDN3/DPYSL2/ATF5/MX2/PRNP/LRRK2/ARHGEF2/GABARAP/BLOC1S2/HSPH1/ARL8B/APC/PAK1/SVBP/CEP350/ARL4C/TAOK1/RGS2/RCC2/APPL1/KIF5B	24
GO:1901505	carbohydrate derivative transmembrane transporter activity	4/1094	53/18367	0.388920762677736	0.750174397929211	SLC15A3/SLC25A24/ABCC3/SLC37A2	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/1094	38/18367	0.396404949827464	0.756463570009497	FKBP15/FKBP5/PPIF	3
GO:0004520	endodeoxyribonuclease activity	3/1094	38/18367	0.396404949827464	0.756463570009497	DNASE2/ERCC1/MBD4	3
GO:0005501	retinoid binding	3/1094	38/18367	0.396404949827464	0.756463570009497	FABP5/RBP7/IGF2R	3
GO:0019840	isoprenoid binding	3/1094	38/18367	0.396404949827464	0.756463570009497	FABP5/RBP7/IGF2R	3
GO:0005158	insulin receptor binding	2/1094	23/18367	0.401746722112525	0.756463570009497	CCDC88A/PIK3R1	2
GO:0008143	poly(A) binding	2/1094	23/18367	0.401746722112525	0.756463570009497	PABPC1/PABPC4	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/1094	23/18367	0.401746722112525	0.756463570009497	CCL3/MAPKAPK3	2
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	2/1094	23/18367	0.401746722112525	0.756463570009497	ALOX5AP/ALOX5	2
GO:0017025	TBP-class protein binding	2/1094	23/18367	0.401746722112525	0.756463570009497	AHR/DRAP1	2
GO:0050750	low-density lipoprotein particle receptor binding	2/1094	23/18367	0.401746722112525	0.756463570009497	APOE/PICALM	2
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	2/1094	23/18367	0.401746722112525	0.756463570009497	TNFAIP3/TAB2	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/1094	23/18367	0.401746722112525	0.756463570009497	MGAT4A/MGAT1	2
GO:0043177	organic acid binding	9/1094	135/18367	0.413307349945018	0.776690445738261	FABP5/GCHFR/GLUL/ALOX5AP/DDAH2/P4HA1/IGF2R/SLC1A3/SCP2	9
GO:0004175	endopeptidase activity	27/1094	430/18367	0.416489040075513	0.779019298646871	CTSD/CTSB/CTSZ/CTSS/CFD/CTSH/LGMN/PYCARD/PSMB9/TPP1/CTSC/PSMB8/CASP1/ST14/C2/PLAU/ADAM8/MMP2/ERAP2/ADAM9/CAPNS1/PSMB10/HTRA1/HM13/ADAM17/ADAM10/SEC11A	27
GO:0003707	steroid hormone receptor activity	2/1094	24/18367	0.422894141228856	0.779019298646871	ABHD2/NR3C1	2
GO:0004622	lysophospholipase activity	2/1094	24/18367	0.422894141228856	0.779019298646871	ABHD12/PLA2G15	2
GO:0010857	calcium-dependent protein kinase activity	2/1094	24/18367	0.422894141228856	0.779019298646871	CCL3/MAPKAPK3	2
GO:0015252	proton channel activity	2/1094	24/18367	0.422894141228856	0.779019298646871	ATP6V1A/HVCN1	2
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	2/1094	24/18367	0.422894141228856	0.779019298646871	ALOX5AP/ALOX5	2
GO:0043495	protein-membrane adaptor activity	2/1094	24/18367	0.422894141228856	0.779019298646871	LPL/CIB1	2
GO:0051537	2 iron, 2 sulfur cluster binding	2/1094	24/18367	0.422894141228856	0.779019298646871	CISD2/CISD3	2
GO:0070840	dynein complex binding	2/1094	24/18367	0.422894141228856	0.779019298646871	RAB29/APC	2
GO:0015144	carbohydrate transmembrane transporter activity	3/1094	40/18367	0.42886774252203	0.779019298646871	AQP9/SLC2A3/TMEM144	3
GO:0051287	NAD binding	4/1094	56/18367	0.42983641240375	0.779019298646871	ALDH2/ALDH1A1/ME2/LDHA	4
GO:0008081	phosphoric diester hydrolase activity	6/1094	89/18367	0.438410695094538	0.779019298646871	PLD3/HMOX1/GPCPD1/CCR1/TDP2/GNB1	6
GO:0019888	protein phosphatase regulator activity	6/1094	89/18367	0.438410695094538	0.779019298646871	LGALS3/PHACTR1/EIF2AK2/CALM3/PPP1R15A/BOD1L1	6
GO:0106306	protein serine phosphatase activity	5/1094	73/18367	0.440994651823105	0.779019298646871	DUSP1/DUSP23/PPM1M/DUSP2/DUSP3	5
GO:0106307	protein threonine phosphatase activity	5/1094	73/18367	0.440994651823105	0.779019298646871	DUSP1/DUSP23/PPM1M/DUSP2/DUSP3	5
GO:0016757	glycosyltransferase activity	17/1094	270/18367	0.442421575423768	0.779019298646871	TYMP/MGAT4A/UPP1/MGAT1/PARP9/ST8SIA4/COLGALT1/NAMPT/CSGALNACT2/LFNG/PARP12/PARP4/LACC1/PARP14/HPRT1/HEXA/B3GNT2	17
GO:0004536	deoxyribonuclease activity	4/1094	57/18367	0.443322494088555	0.779019298646871	DNASE2/PLD3/ERCC1/MBD4	4
GO:0005112	Notch binding	2/1094	25/18367	0.443647322876681	0.779019298646871	NCOR2/ADAM17	2
GO:0016859	cis-trans isomerase activity	3/1094	41/18367	0.444866195595742	0.779019298646871	FKBP15/FKBP5/PPIF	3
GO:0020037	heme binding	9/1094	139/18367	0.447664394758146	0.779019298646871	CYBA/HMOX1/CYBB/TBXAS1/CYP27A1/JAK2/CYB5R4/PTGS1/BACH1	9
GO:0003697	single-stranded DNA binding	8/1094	123/18367	0.451380721934793	0.779019298646871	SAMHD1/YBX1/TDP2/ERCC1/RECQL/FAM111A/CNBP/PCBP2	8
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/1094	10/18367	0.458961644545741	0.779019298646871	ERCC1	1
GO:0004300	enoyl-CoA hydratase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	HSD17B4	1
GO:0004465	lipoprotein lipase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	LPL	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	PTPN18	1
GO:0004955	prostaglandin receptor activity	1/1094	10/18367	0.458961644545741	0.779019298646871	PTGER4	1
GO:0005432	calcium:sodium antiporter activity	1/1094	10/18367	0.458961644545741	0.779019298646871	SLC8A1	1
GO:0005528	FK506 binding	1/1094	10/18367	0.458961644545741	0.779019298646871	FKBP5	1
GO:0008097	5S rRNA binding	1/1094	10/18367	0.458961644545741	0.779019298646871	GTF3A	1
GO:0008190	eukaryotic initiation factor 4E binding	1/1094	10/18367	0.458961644545741	0.779019298646871	EIF4EBP1	1
GO:0008526	phosphatidylinositol transfer activity	1/1094	10/18367	0.458961644545741	0.779019298646871	PLTP	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	MAN1A1	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	ATM	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/1094	10/18367	0.458961644545741	0.779019298646871	CYB5R4	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/1094	10/18367	0.458961644545741	0.779019298646871	SCD	1
GO:0016803	ether hydrolase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	LTA4H	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/1094	10/18367	0.458961644545741	0.779019298646871	DHRS4	1
GO:0019203	carbohydrate phosphatase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	FBP1	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	ACSL4	1
GO:0035374	chondroitin sulfate binding	1/1094	10/18367	0.458961644545741	0.779019298646871	ADGRE2	1
GO:0035612	AP-2 adaptor complex binding	1/1094	10/18367	0.458961644545741	0.779019298646871	BMP2K	1
GO:0045294	alpha-catenin binding	1/1094	10/18367	0.458961644545741	0.779019298646871	NUMB	1
GO:0045503	dynein light chain binding	1/1094	10/18367	0.458961644545741	0.779019298646871	GLUL	1
GO:0046030	inositol trisphosphate phosphatase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	INPP5D	1
GO:0050308	sugar-phosphatase activity	1/1094	10/18367	0.458961644545741	0.779019298646871	FBP1	1
GO:0051880	G-quadruplex DNA binding	1/1094	10/18367	0.458961644545741	0.779019298646871	CNBP	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/1094	10/18367	0.458961644545741	0.779019298646871	CASP1	1
GO:0120016	sphingolipid transfer activity	1/1094	10/18367	0.458961644545741	0.779019298646871	PLTP	1
GO:0022804	active transmembrane transporter activity	25/1094	406/18367	0.461372720338955	0.779019298646871	ATP6V1F/SLC8A1/SLC11A1/SLCO2B1/SLC15A3/SLC16A3/ATP6V1B2/ATP6V0D1/TAPBP/SLC4A7/TAP1/ATP6V1A/ABCC3/SLC37A2/SLC6A6/ATP1B1/ATP2C1/MFSD12/ABCG1/ABCA1/ATP6V0E1/SLC1A3/CLCN7/ATP1B3/ATP1A1	25
GO:0004806	triglyceride lipase activity	2/1094	26/18367	0.463978188253104	0.779019298646871	LPL/ABHD2	2
GO:0042974	retinoic acid receptor binding	2/1094	26/18367	0.463978188253104	0.779019298646871	NR4A2/NCOR2	2
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	2/1094	26/18367	0.463978188253104	0.779019298646871	ABCC3/CLCN7	2
GO:0099604	ligand-gated calcium channel activity	2/1094	26/18367	0.463978188253104	0.779019298646871	TRPM2/MCOLN1	2
GO:0098631	cell adhesion mediator activity	4/1094	59/18367	0.469987991865377	0.779019298646871	SIRPA/NINJ1/RAB10/S100A11	4
GO:0051213	dioxygenase activity	6/1094	92/18367	0.470324847824742	0.779019298646871	ALOX5AP/ALOX5/PTGS1/P4HA1/JMJD1C/ALKBH7	6
GO:0016791	phosphatase activity	17/1094	275/18367	0.47306148297004	0.779019298646871	ACP5/FBP1/DUSP1/PTPRC/DUSP23/PTPN6/PPM1M/INPP5D/LRRK2/DUSP2/PTPN18/PTPRJ/MTMR6/PTP4A2/ACP2/DUSP3/ATP1A1	17
GO:0005246	calcium channel regulator activity	3/1094	43/18367	0.47630348928355	0.779019298646871	SGK1/SGK3/SLC30A1	3
GO:0030544	Hsp70 protein binding	3/1094	43/18367	0.47630348928355	0.779019298646871	SPN/NUP62/BAX	3
GO:0001671	ATPase activator activity	2/1094	27/18367	0.483863395207636	0.779019298646871	ATP1B1/ATP1B3	2
GO:0004190	aspartic-type endopeptidase activity	2/1094	27/18367	0.483863395207636	0.779019298646871	CTSD/HM13	2
GO:0015215	nucleotide transmembrane transporter activity	2/1094	27/18367	0.483863395207636	0.779019298646871	SLC25A24/SLC25A19	2
GO:0015491	cation:cation antiporter activity	2/1094	27/18367	0.483863395207636	0.779019298646871	SLC8A1/SLC11A1	2
GO:0016405	CoA-ligase activity	2/1094	27/18367	0.483863395207636	0.779019298646871	ACSL1/ACSL4	2
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/1094	27/18367	0.483863395207636	0.779019298646871	INPP5D/MTMR6	2
GO:0035255	ionotropic glutamate receptor binding	2/1094	27/18367	0.483863395207636	0.779019298646871	CANX/FLOT1	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/1094	11/18367	0.491205255204725	0.779019298646871	BCL6	1
GO:0002162	dystroglycan binding	1/1094	11/18367	0.491205255204725	0.779019298646871	PLEC	1
GO:0004016	adenylate cyclase activity	1/1094	11/18367	0.491205255204725	0.779019298646871	ADCY7	1
GO:0004954	prostanoid receptor activity	1/1094	11/18367	0.491205255204725	0.779019298646871	PTGER4	1
GO:0005049	nuclear export signal receptor activity	1/1094	11/18367	0.491205255204725	0.779019298646871	NUP214	1
GO:0005247	voltage-gated chloride channel activity	1/1094	11/18367	0.491205255204725	0.779019298646871	CLCN7	1
GO:0005347	ATP transmembrane transporter activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC25A24	1
GO:0005536	glucose binding	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC2A3	1
GO:0008503	benzodiazepine receptor activity	1/1094	11/18367	0.491205255204725	0.779019298646871	TSPO	1
GO:0015368	calcium:cation antiporter activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC8A1	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/1094	11/18367	0.491205255204725	0.779019298646871	ERO1A	1
GO:0016801	hydrolase activity, acting on ether bonds	1/1094	11/18367	0.491205255204725	0.779019298646871	LTA4H	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/1094	11/18367	0.491205255204725	0.779019298646871	DDAH2	1
GO:0016832	aldehyde-lyase activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SGPL1	1
GO:0017128	phospholipid scramblase activity	1/1094	11/18367	0.491205255204725	0.779019298646871	PLSCR1	1
GO:0019107	myristoyltransferase activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SCP2	1
GO:0019855	calcium channel inhibitor activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC30A1	1
GO:0022889	serine transmembrane transporter activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SFXN3	1
GO:0035197	siRNA binding	1/1094	11/18367	0.491205255204725	0.779019298646871	TLR7	1
GO:0035673	oligopeptide transmembrane transporter activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC15A3	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/1094	11/18367	0.491205255204725	0.779019298646871	MTMR6	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/1094	11/18367	0.491205255204725	0.779019298646871	SIRPA	1
GO:0097493	structural molecule activity conferring elasticity	1/1094	11/18367	0.491205255204725	0.779019298646871	EMILIN2	1
GO:0099186	structural constituent of postsynapse	1/1094	11/18367	0.491205255204725	0.779019298646871	ACTB	1
GO:0102545	phosphatidyl phospholipase B activity	1/1094	11/18367	0.491205255204725	0.779019298646871	PLA2G15	1
GO:0140036	ubiquitin-dependent protein binding	1/1094	11/18367	0.491205255204725	0.779019298646871	LAPTM5	1
GO:1901474	azole transmembrane transporter activity	1/1094	11/18367	0.491205255204725	0.779019298646871	SLC25A19	1
GO:1990459	transferrin receptor binding	1/1094	11/18367	0.491205255204725	0.779019298646871	CD81	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	3/1094	44/18367	0.491709757523156	0.779019298646871	SGK1/RPS6KA1/MAPKAPK3	3
GO:0032182	ubiquitin-like protein binding	7/1094	111/18367	0.494156193795681	0.781590379853503	CXCR4/UBE2L6/GGA2/GGA1/TNFAIP3/TAB2/NUP62	7
GO:0017056	structural constituent of nuclear pore	2/1094	28/18367	0.503283874483487	0.793382719077789	NUP214/NUP62	2
GO:0070001	aspartic-type peptidase activity	2/1094	28/18367	0.503283874483487	0.793382719077789	CTSD/HM13	2
GO:0008509	anion transmembrane transporter activity	19/1094	314/18367	0.505773321373157	0.794216281569503	CD36/SLCO2B1/SLC16A3/SLC25A24/SLC4A7/SLC38A6/SLC25A19/ABCC3/LRRC8C/MPC1/TTYH3/SLC37A2/SLC6A6/SFXN3/SLC2A3/MFSD12/SLC1A3/CLIC1/CLCN7	19
GO:0000340	RNA 7-methylguanosine cap binding	1/1094	12/18367	0.521528934154715	0.794216281569503	CYFIP1	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/1094	12/18367	0.521528934154715	0.794216281569503	AKR1A1	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/1094	12/18367	0.521528934154715	0.794216281569503	CDKN1A	1
GO:0005095	GTPase inhibitor activity	1/1094	12/18367	0.521528934154715	0.794216281569503	IQGAP1	1
GO:0005527	macrolide binding	1/1094	12/18367	0.521528934154715	0.794216281569503	FKBP5	1
GO:0015166	polyol transmembrane transporter activity	1/1094	12/18367	0.521528934154715	0.794216281569503	AQP9	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/1094	12/18367	0.521528934154715	0.794216281569503	SLC25A19	1
GO:0017166	vinculin binding	1/1094	12/18367	0.521528934154715	0.794216281569503	TLN1	1
GO:0022858	alanine transmembrane transporter activity	1/1094	12/18367	0.521528934154715	0.794216281569503	SLC6A6	1
GO:0031543	peptidyl-proline dioxygenase activity	1/1094	12/18367	0.521528934154715	0.794216281569503	P4HA1	1
GO:0033130	acetylcholine receptor binding	1/1094	12/18367	0.521528934154715	0.794216281569503	JAK2	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/1094	12/18367	0.521528934154715	0.794216281569503	ATM	1
GO:0046790	virion binding	1/1094	12/18367	0.521528934154715	0.794216281569503	SIGLEC1	1
GO:0061578	Lys63-specific deubiquitinase activity	1/1094	12/18367	0.521528934154715	0.794216281569503	TNFAIP3	1
GO:0089720	caspase binding	1/1094	12/18367	0.521528934154715	0.794216281569503	CARD16	1
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	1/1094	12/18367	0.521528934154715	0.794216281569503	KCNE3	1
GO:0004864	protein phosphatase inhibitor activity	3/1094	46/18367	0.521827647898225	0.794216281569503	LGALS3/PHACTR1/BOD1L1	3
GO:0061980	regulatory RNA binding	3/1094	46/18367	0.521827647898225	0.794216281569503	NEAT1/TLR7/YBX1	3
GO:0140296	general transcription initiation factor binding	3/1094	46/18367	0.521827647898225	0.794216281569503	AHR/ERCC1/DRAP1	3
GO:0005520	insulin-like growth factor binding	2/1094	29/18367	0.522224404319673	0.794216281569503	IGF2R/HTRA1	2
GO:0035250	UDP-galactosyltransferase activity	2/1094	29/18367	0.522224404319673	0.794216281569503	COLGALT1/B3GNT2	2
GO:0048018	receptor ligand activity	29/1094	487/18367	0.528508921619629	0.802487946587244	SPP1/GPNMB/TYMP/TIMP1/CCL3/GRN/CCL3L3/HAMP/CXCL16/TNFSF13B/LGALS3/IL18/CKLF/HGF/CCL4/RETN/GMFG/METRNL/CMTM3/HBEGF/VEGFA/TNFSF12/TGFB1/CMTM7/NAMPT/SECTM1/TNFSF10/IL1B/VEGFB	29
GO:0046906	tetrapyrrole binding	9/1094	149/18367	0.531814263185973	0.806216830293113	CYBA/HMOX1/CYBB/TBXAS1/CYP27A1/JAK2/CYB5R4/PTGS1/BACH1	9
GO:0003712	transcription coregulator activity	29/1094	489/18367	0.537672448312085	0.809293817656501	NUPR1/MTDH/RB1/CREG1/TRIM22/HSPA1A/ZMIZ1/PARP9/CIITA/LMO2/NCOR2/LPXN/SAP30/FHL3/TRIM14/TRIM38/TDP2/PARP14/BTG2/JMJD1C/DRAP1/BTG1/TLE3/PFDN5/IRF2BP2/UBE3A/SPEN/MAML2/PIAS1	29
GO:0005217	intracellular ligand-gated ion channel activity	2/1094	30/18367	0.540673220495863	0.809293817656501	TRPM2/MCOLN1	2
GO:0005343	organic acid:sodium symporter activity	2/1094	30/18367	0.540673220495863	0.809293817656501	SLC6A6/SLC1A3	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/1094	30/18367	0.540673220495863	0.809293817656501	HSD17B11/HSD17B4	2
GO:0004859	phospholipase inhibitor activity	1/1094	13/18367	0.550046904518907	0.809293817656501	APOC1	1
GO:0015250	water channel activity	1/1094	13/18367	0.550046904518907	0.809293817656501	AQP9	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/1094	13/18367	0.550046904518907	0.809293817656501	TRMT1	1
GO:0019104	DNA N-glycosylase activity	1/1094	13/18367	0.550046904518907	0.809293817656501	MBD4	1
GO:0031432	titin binding	1/1094	13/18367	0.550046904518907	0.809293817656501	CALM3	1
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	1/1094	13/18367	0.550046904518907	0.809293817656501	JMJD1C	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/1094	13/18367	0.550046904518907	0.809293817656501	INPP5D	1
GO:0039706	co-receptor binding	1/1094	13/18367	0.550046904518907	0.809293817656501	LRRK2	1
GO:0045159	myosin II binding	1/1094	13/18367	0.550046904518907	0.809293817656501	GSN	1
GO:0045504	dynein heavy chain binding	1/1094	13/18367	0.550046904518907	0.809293817656501	DYNC1LI1	1
GO:0061783	peptidoglycan muralytic activity	1/1094	13/18367	0.550046904518907	0.809293817656501	LYZ	1
GO:0070700	BMP receptor binding	1/1094	13/18367	0.550046904518907	0.809293817656501	PYCARD	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/1094	13/18367	0.550046904518907	0.809293817656501	HSD17B11	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/1094	13/18367	0.550046904518907	0.809293817656501	INPP5D	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/1094	13/18367	0.550046904518907	0.809293817656501	LAPTM5	1
GO:0016878	acid-thiol ligase activity	2/1094	31/18367	0.558621659113003	0.818104868052839	ACSL1/ACSL4	2
GO:0042910	xenobiotic transmembrane transporter activity	2/1094	31/18367	0.558621659113003	0.818104868052839	ABCC3/SLC6A6	2
GO:0090482	vitamin transmembrane transporter activity	2/1094	31/18367	0.558621659113003	0.818104868052839	SLC25A19/SLC2A3	2
GO:0030546	signaling receptor activator activity	29/1094	495/18367	0.56487638074582	0.820759225145888	SPP1/GPNMB/TYMP/TIMP1/CCL3/GRN/CCL3L3/HAMP/CXCL16/TNFSF13B/LGALS3/IL18/CKLF/HGF/CCL4/RETN/GMFG/METRNL/CMTM3/HBEGF/VEGFA/TNFSF12/TGFB1/CMTM7/NAMPT/SECTM1/TNFSF10/IL1B/VEGFB	29
GO:0019212	phosphatase inhibitor activity	3/1094	49/18367	0.565100795462012	0.820759225145888	LGALS3/PHACTR1/BOD1L1	3
GO:0098632	cell-cell adhesion mediator activity	3/1094	49/18367	0.565100795462012	0.820759225145888	SIRPA/RAB10/S100A11	3
GO:0001223	transcription coactivator binding	2/1094	32/18367	0.576063829598991	0.820759225145888	HIF1A/AHR	2
GO:0008378	galactosyltransferase activity	2/1094	32/18367	0.576063829598991	0.820759225145888	COLGALT1/B3GNT2	2
GO:0030332	cyclin binding	2/1094	32/18367	0.576063829598991	0.820759225145888	MDFIC/CDKN1A	2
GO:0140658	ATP-dependent chromatin remodeler activity	2/1094	32/18367	0.576063829598991	0.820759225145888	CHD9/CHD4	2
GO:0008013	beta-catenin binding	5/1094	85/18367	0.576558298001045	0.820759225145888	NR4A2/KLF4/PTPRJ/NUMB/APC	5
GO:0005313	L-glutamate transmembrane transporter activity	1/1094	14/18367	0.576866599760071	0.820759225145888	SLC1A3	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/1094	14/18367	0.576866599760071	0.820759225145888	B3GNT2	1
GO:0015926	glucosidase activity	1/1094	14/18367	0.576866599760071	0.820759225145888	GAA	1
GO:0017110	nucleoside-diphosphatase activity	1/1094	14/18367	0.576866599760071	0.820759225145888	ENTPD1	1
GO:0019992	diacylglycerol binding	1/1094	14/18367	0.576866599760071	0.820759225145888	PLTP	1
GO:0036041	long-chain fatty acid binding	1/1094	14/18367	0.576866599760071	0.820759225145888	ALOX5AP	1
GO:0070411	I-SMAD binding	1/1094	14/18367	0.576866599760071	0.820759225145888	TGFBR1	1
GO:0071837	HMG box domain binding	1/1094	14/18367	0.576866599760071	0.820759225145888	JUN	1
GO:0102991	myristoyl-CoA hydrolase activity	1/1094	14/18367	0.576866599760071	0.820759225145888	ACAA2	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/1094	14/18367	0.576866599760071	0.820759225145888	MTMR6	1
GO:0140666	annealing activity	1/1094	14/18367	0.576866599760071	0.820759225145888	RECQL	1
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/1094	50/18367	0.578982063441347	0.822535895517722	CDKN1A/CCNL1/CCNI	3
GO:0051536	iron-sulfur cluster binding	4/1094	68/18367	0.582898500902749	0.825627876651804	DPYD/RSAD2/CISD2/CISD3	4
GO:0051540	metal cluster binding	4/1094	68/18367	0.582898500902749	0.825627876651804	DPYD/RSAD2/CISD2/CISD3	4
GO:0003743	translation initiation factor activity	3/1094	51/18367	0.592580469419629	0.82809061523337	EIF4G3/EIF2S3/EIF1	3
GO:0016860	intramolecular oxidoreductase activity	3/1094	51/18367	0.592580469419629	0.82809061523337	TBXAS1/GNPDA1/ERO1A	3
GO:0004623	phospholipase A2 activity	2/1094	33/18367	0.592996315611248	0.82809061523337	PLA2G7/PLA2G15	2
GO:0008200	ion channel inhibitor activity	2/1094	33/18367	0.592996315611248	0.82809061523337	SLC30A1/WNK1	2
GO:0051427	hormone receptor binding	2/1094	33/18367	0.592996315611248	0.82809061523337	JAK1/JAK2	2
GO:0004559	alpha-mannosidase activity	1/1094	15/18367	0.602089066924158	0.82809061523337	MAN1A1	1
GO:0004953	icosanoid receptor activity	1/1094	15/18367	0.602089066924158	0.82809061523337	PTGER4	1
GO:0005452	inorganic anion exchanger activity	1/1094	15/18367	0.602089066924158	0.82809061523337	SLC4A7	1
GO:0008559	ABC-type xenobiotic transporter activity	1/1094	15/18367	0.602089066924158	0.82809061523337	ABCC3	1
GO:0010851	cyclase regulator activity	1/1094	15/18367	0.602089066924158	0.82809061523337	CALM3	1
GO:0019215	intermediate filament binding	1/1094	15/18367	0.602089066924158	0.82809061523337	VIM	1
GO:0034483	heparan sulfate sulfotransferase activity	1/1094	15/18367	0.602089066924158	0.82809061523337	HS3ST1	1
GO:0042043	neurexin family protein binding	1/1094	15/18367	0.602089066924158	0.82809061523337	SDCBP	1
GO:0043138	3'-5' DNA helicase activity	1/1094	15/18367	0.602089066924158	0.82809061523337	RECQL	1
GO:0045125	bioactive lipid receptor activity	1/1094	15/18367	0.602089066924158	0.82809061523337	LPAR6	1
GO:0051139	metal ion:proton antiporter activity	1/1094	15/18367	0.602089066924158	0.82809061523337	SLC11A1	1
GO:0051371	muscle alpha-actinin binding	1/1094	15/18367	0.602089066924158	0.82809061523337	PDLIM7	1
GO:0071933	Arp2/3 complex binding	1/1094	15/18367	0.602089066924158	0.82809061523337	GMFG	1
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	1/1094	15/18367	0.602089066924158	0.82809061523337	KCNE3	1
GO:1901611	phosphatidylglycerol binding	1/1094	15/18367	0.602089066924158	0.82809061523337	PLTP	1
GO:0016853	isomerase activity	9/1094	158/18367	0.603328974995229	0.828595075644677	DSE/TBXAS1/FUOM/FKBP15/GNPDA1/FKBP5/ERO1A/HSD17B4/PPIF	9
GO:0016830	carbon-carbon lyase activity	3/1094	52/18367	0.605890856782269	0.830911016020771	ME2/SGPL1/NPL	3
GO:0016248	channel inhibitor activity	2/1094	34/18367	0.609417901677726	0.832140415384405	SLC30A1/WNK1	2
GO:0035198	miRNA binding	2/1094	34/18367	0.609417901677726	0.832140415384405	NEAT1/YBX1	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/1094	34/18367	0.609417901677726	0.832140415384405	INPP5D/MTMR6	2
GO:0061659	ubiquitin-like protein ligase activity	18/1094	316/18367	0.612471194159574	0.834119479370592	RNF130/TRIM22/RNF13/DTX3L/TRIM14/TRIM69/RNF149/RNF145/TRIM38/RNF166/RNF135/UBE2D1/CDC42/UBE3A/XIAP/PIAS1/RANBP2/UBE2D3	18
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4/1094	71/18367	0.617318389187371	0.834119479370592	ASAH1/GLS/NTAN1/ACER3	4
GO:1901681	sulfur compound binding	15/1094	265/18367	0.618638971088738	0.834119479370592	APOE/GPNMB/PTPRC/SOAT1/LPL/GAL3ST4/MGST1/HBEGF/VEGFA/ADGRE2/MGST2/LRP1/ACBD5/VEGFB/SCP2	15
GO:0015298	solute:cation antiporter activity	2/1094	35/18367	0.625329323575732	0.834119479370592	SLC8A1/SLC11A1	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/1094	16/18367	0.625809345955597	0.834119479370592	CAPNS1	1
GO:0004698	calcium-dependent protein kinase C activity	1/1094	16/18367	0.625809345955597	0.834119479370592	CCL3	1
GO:0005283	amino acid:sodium symporter activity	1/1094	16/18367	0.625809345955597	0.834119479370592	SLC1A3	1
GO:0005372	water transmembrane transporter activity	1/1094	16/18367	0.625809345955597	0.834119479370592	AQP9	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/1094	16/18367	0.625809345955597	0.834119479370592	SLC1A3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/1094	16/18367	0.625809345955597	0.834119479370592	SLCO2B1	1
GO:0015923	mannosidase activity	1/1094	16/18367	0.625809345955597	0.834119479370592	MAN1A1	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/1094	16/18367	0.625809345955597	0.834119479370592	IL4I1	1
GO:0019841	retinol binding	1/1094	16/18367	0.625809345955597	0.834119479370592	RBP7	1
GO:0035173	histone kinase activity	1/1094	16/18367	0.625809345955597	0.834119479370592	JAK2	1
GO:0035497	cAMP response element binding	1/1094	16/18367	0.625809345955597	0.834119479370592	JUN	1
GO:0036122	BMP binding	1/1094	16/18367	0.625809345955597	0.834119479370592	ENG	1
GO:0140327	flippase activity	1/1094	16/18367	0.625809345955597	0.834119479370592	TMEM30A	1
GO:0090079	translation regulator activity, nucleic acid binding	6/1094	108/18367	0.628254462520649	0.835211354931286	PABPC1/MIF4GD/RPS27L/EIF4G3/EIF2S3/EIF1	6
GO:0003678	DNA helicase activity	4/1094	72/18367	0.628388732793401	0.835211354931286	CHD9/RECQL/SETX/CHD4	4
GO:0019787	ubiquitin-like protein transferase activity	26/1094	458/18367	0.629725334521035	0.835817262182465	RNF130/RNF213/UBE2L6/TRIM22/RNF13/DTX3L/TRIM14/TRIM69/RNF149/RNF145/TRIM38/RNF166/TNFAIP3/RNF135/UBE2W/UBE2D1/PJA2/ATG3/TTC3/CDC42/UBE3A/XIAP/PIAS1/RANBP2/UBE2D3/SUMO2	26
GO:0016746	acyltransferase activity	14/1094	250/18367	0.633188442022637	0.838250933951884	GLUL/SOAT1/LPCAT2/CIITA/AGPAT2/ACAA2/QPCT/LPGAT1/SAT1/ACAT1/CPT1A/SAT2/PLA2G15/SCP2	14
GO:0008083	growth factor activity	9/1094	162/18367	0.633325521226028	0.838250933951884	TYMP/TIMP1/GRN/HGF/GMFG/HBEGF/VEGFA/TGFB1/VEGFB	9
GO:0016407	acetyltransferase activity	5/1094	91/18367	0.637438703078342	0.842519957132794	LPCAT2/ACAA2/SAT1/ACAT1/SAT2	5
GO:0004697	protein kinase C activity	1/1094	17/18367	0.648116826502955	0.843707638341981	CCL3	1
GO:0008308	voltage-gated anion channel activity	1/1094	17/18367	0.648116826502955	0.843707638341981	CLCN7	1
GO:0008381	mechanosensitive ion channel activity	1/1094	17/18367	0.648116826502955	0.843707638341981	TMC6	1
GO:0008574	plus-end-directed microtubule motor activity	1/1094	17/18367	0.648116826502955	0.843707638341981	KIF5B	1
GO:0015108	chloride transmembrane transporter activity	1/1094	17/18367	0.648116826502955	0.843707638341981	CLCN7	1
GO:0015174	basic amino acid transmembrane transporter activity	1/1094	17/18367	0.648116826502955	0.843707638341981	SLC7A7	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/1094	17/18367	0.648116826502955	0.843707638341981	FTH1	1
GO:0043024	ribosomal small subunit binding	1/1094	17/18367	0.648116826502955	0.843707638341981	EIF1	1
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	1/1094	17/18367	0.648116826502955	0.843707638341981	ATP6V1A	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/1094	17/18367	0.648116826502955	0.843707638341981	B3GNT2	1
GO:0052745	inositol phosphate phosphatase activity	1/1094	17/18367	0.648116826502955	0.843707638341981	INPP5D	1
GO:0016409	palmitoyltransferase activity	2/1094	37/18367	0.655633027964598	0.849994185161753	GLUL/CPT1A	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/1094	37/18367	0.655633027964598	0.849994185161753	ALDH2/ALDH1A1	2
GO:0071949	FAD binding	2/1094	37/18367	0.655633027964598	0.849994185161753	NQO2/ERO1A	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/1094	18/18367	0.669095583549591	0.852343927064045	SLC25A24	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/1094	18/18367	0.669095583549591	0.852343927064045	MTMR6	1
GO:0004708	MAP kinase kinase activity	1/1094	18/18367	0.669095583549591	0.852343927064045	MAPKAPK3	1
GO:0005229	intracellular calcium activated chloride channel activity	1/1094	18/18367	0.669095583549591	0.852343927064045	TTYH3	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/1094	18/18367	0.669095583549591	0.852343927064045	SLC25A24	1
GO:0008409	5'-3' exonuclease activity	1/1094	18/18367	0.669095583549591	0.852343927064045	PLD3	1
GO:0016755	aminoacyltransferase activity	1/1094	18/18367	0.669095583549591	0.852343927064045	QPCT	1
GO:0048038	quinone binding	1/1094	18/18367	0.669095583549591	0.852343927064045	VKORC1	1
GO:0050811	GABA receptor binding	1/1094	18/18367	0.669095583549591	0.852343927064045	GABARAP	1
GO:0055102	lipase inhibitor activity	1/1094	18/18367	0.669095583549591	0.852343927064045	APOC1	1
GO:0061778	intracellular chloride channel activity	1/1094	18/18367	0.669095583549591	0.852343927064045	TTYH3	1
GO:0098918	structural constituent of synapse	1/1094	18/18367	0.669095583549591	0.852343927064045	ACTB	1
GO:0043021	ribonucleoprotein complex binding	8/1094	149/18367	0.669121417979677	0.852343927064045	NEAT1/IFIH1/RNF135/DDX5/TMCO1/OXA1L/EIF1/UHMK1	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	12/1094	222/18367	0.67711270511634	0.861367234792771	GLUL/SOAT1/LPCAT2/AGPAT2/ACAA2/LPGAT1/SAT1/ACAT1/CPT1A/SAT2/PLA2G15/SCP2	12
GO:0003774	cytoskeletal motor activity	6/1094	114/18367	0.679904260443398	0.863760566480301	MYO5A/MYO9B/MYO1F/MYO1G/MYL6/KIF5B	6
GO:0005506	iron ion binding	8/1094	151/18367	0.683571584942305	0.867258601751667	FTL/FTH1/ACP5/ALOX5/TBXAS1/CYP27A1/SCD/P4HA1	8
GO:0004970	ionotropic glutamate receptor activity	1/1094	19/18367	0.688824693124867	0.86812036357968	PTK2B	1
GO:0016918	retinal binding	1/1094	19/18367	0.688824693124867	0.86812036357968	RBP7	1
GO:0035615	clathrin adaptor activity	1/1094	19/18367	0.688824693124867	0.86812036357968	AP1S2	1
GO:0052742	phosphatidylinositol kinase activity	1/1094	19/18367	0.688824693124867	0.86812036357968	ATM	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/1094	19/18367	0.688824693124867	0.86812036357968	MTMR6	1
GO:0015081	sodium ion transmembrane transporter activity	8/1094	152/18367	0.690647490985237	0.869263221412454	SLC8A1/SLC4A7/TRPM2/SLC6A6/ATP1B1/SLC1A3/ATP1B3/ATP1A1	8
GO:0031492	nucleosomal DNA binding	2/1094	40/18367	0.697369253036632	0.874562736925752	ACTB/CHD4	2
GO:0044183	protein folding chaperone	2/1094	40/18367	0.697369253036632	0.874562736925752	CD74/HSPA1A	2
GO:0001653	peptide receptor activity	8/1094	153/18367	0.6976227522158	0.874562736925752	CXCR4/FPR3/FPR1/CCR1/CCRL2/AGTRAP/OGFR/OGFRL1	8
GO:0015085	calcium ion transmembrane transporter activity	7/1094	135/18367	0.700110890231437	0.875231061647953	SLC8A1/TRPM2/ORAI2/ATP2C1/MCOLN1/ORAI3/TMCO1	7
GO:0003756	protein disulfide isomerase activity	1/1094	20/18367	0.707378529277112	0.875231061647953	ERO1A	1
GO:0004551	nucleotide diphosphatase activity	1/1094	20/18367	0.707378529277112	0.875231061647953	NUDT3	1
GO:0016018	cyclosporin A binding	1/1094	20/18367	0.707378529277112	0.875231061647953	PPIF	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/1094	20/18367	0.707378529277112	0.875231061647953	IL4I1	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	1/1094	20/18367	0.707378529277112	0.875231061647953	ERO1A	1
GO:0031418	L-ascorbic acid binding	1/1094	20/18367	0.707378529277112	0.875231061647953	P4HA1	1
GO:0031690	adrenergic receptor binding	1/1094	20/18367	0.707378529277112	0.875231061647953	ARRB2	1
GO:0070300	phosphatidic acid binding	1/1094	20/18367	0.707378529277112	0.875231061647953	PLTP	1
GO:0140312	cargo adaptor activity	1/1094	20/18367	0.707378529277112	0.875231061647953	AP1S2	1
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/1094	41/18367	0.710318127777191	0.877723832370513	ACSL1/ACSL4	2
GO:0015179	L-amino acid transmembrane transporter activity	3/1094	61/18367	0.712316453348896	0.879048523053449	SLC7A7/SLC38A6/SLC1A3	3
GO:0004386	helicase activity	8/1094	156/18367	0.717937569684937	0.881872902827089	CHD9/DDX60L/SLFN11/IFIH1/RECQL/SETX/DDX5/CHD4	8
GO:0008307	structural constituent of muscle	2/1094	42/18367	0.722799843916051	0.881872902827089	MYL6/PLEC	2
GO:0051539	4 iron, 4 sulfur cluster binding	2/1094	42/18367	0.722799843916051	0.881872902827089	DPYD/RSAD2	2
GO:0005385	zinc ion transmembrane transporter activity	1/1094	21/18367	0.724827043419525	0.881872902827089	SLC30A1	1
GO:0008373	sialyltransferase activity	1/1094	21/18367	0.724827043419525	0.881872902827089	ST8SIA4	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/1094	21/18367	0.724827043419525	0.881872902827089	SLC25A24	1
GO:0019200	carbohydrate kinase activity	1/1094	21/18367	0.724827043419525	0.881872902827089	NAGK	1
GO:0051010	microtubule plus-end binding	1/1094	21/18367	0.724827043419525	0.881872902827089	APC	1
GO:0051428	peptide hormone receptor binding	1/1094	21/18367	0.724827043419525	0.881872902827089	JAK2	1
GO:0140416	transcription regulator inhibitor activity	1/1094	21/18367	0.724827043419525	0.881872902827089	ID2	1
GO:1990381	ubiquitin-specific protease binding	1/1094	21/18367	0.724827043419525	0.881872902827089	CHMP3	1
GO:0061630	ubiquitin protein ligase activity	16/1094	304/18367	0.731089527776222	0.888353344250493	RNF130/TRIM22/RNF13/DTX3L/TRIM14/TRIM69/RNF149/RNF145/TRIM38/RNF166/RNF135/UBE2D1/CDC42/UBE3A/XIAP/UBE2D3	16
GO:0005355	glucose transmembrane transporter activity	1/1094	22/18367	0.741236027094388	0.893010409872602	SLC2A3	1
GO:0005416	amino acid:cation symporter activity	1/1094	22/18367	0.741236027094388	0.893010409872602	SLC1A3	1
GO:0008093	cytoskeletal anchor activity	1/1094	22/18367	0.741236027094388	0.893010409872602	SDCBP	1
GO:0015106	bicarbonate transmembrane transporter activity	1/1094	22/18367	0.741236027094388	0.893010409872602	SLC4A7	1
GO:0015149	hexose transmembrane transporter activity	1/1094	22/18367	0.741236027094388	0.893010409872602	SLC2A3	1
GO:0070034	telomerase RNA binding	1/1094	22/18367	0.741236027094388	0.893010409872602	NOP10	1
GO:0031490	chromatin DNA binding	5/1094	103/18367	0.741741345444624	0.893010409872602	ACTB/BCL6/JMJD1C/STAT3/CHD4	5
GO:0016836	hydro-lyase activity	3/1094	64/18367	0.742450172170162	0.893010409872602	TBXAS1/HACD4/HSD17B4	3
GO:0030165	PDZ domain binding	4/1094	84/18367	0.744680062684845	0.894361717671808	DOCK4/SDC2/PLEKHA2/ADAM17	4
GO:0008017	microtubule binding	14/1094	271/18367	0.746371965729218	0.894361717671808	CCDC88A/MX1/RMDN3/DPYSL2/MX2/PRNP/LRRK2/ARHGEF2/GABARAP/APC/SVBP/CEP350/RCC2/KIF5B	14
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/1094	44/18367	0.746400927709243	0.894361717671808	ALDH2/ALDH1A1	2
GO:0050660	flavin adenine dinucleotide binding	4/1094	85/18367	0.752982372051946	0.898720054847219	CYBB/DPYD/NQO2/ERO1A	4
GO:0008194	UDP-glycosyltransferase activity	7/1094	143/18367	0.754915760067256	0.898720054847219	MGAT4A/MGAT1/COLGALT1/CSGALNACT2/LFNG/HEXA/B3GNT2	7
GO:0004529	exodeoxyribonuclease activity	1/1094	23/18367	0.756667359139018	0.898720054847219	PLD3	1
GO:0005212	structural constituent of eye lens	1/1094	23/18367	0.756667359139018	0.898720054847219	VIM	1
GO:0015299	solute:proton antiporter activity	1/1094	23/18367	0.756667359139018	0.898720054847219	SLC11A1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1094	23/18367	0.756667359139018	0.898720054847219	PLD3	1
GO:0030552	cAMP binding	1/1094	23/18367	0.756667359139018	0.898720054847219	PRKAR1A	1
GO:0002039	p53 binding	3/1094	66/18367	0.761106482722367	0.902862565129408	HIF1A/PLK3/ZNF385A	3
GO:0005253	anion channel activity	4/1094	87/18367	0.76896080062299	0.909129313082587	LRRC8C/TTYH3/CLIC1/CLCN7	4
GO:0015145	monosaccharide transmembrane transporter activity	1/1094	24/18367	0.77117923817859	0.909129313082587	SLC2A3	1
GO:0015295	solute:proton symporter activity	1/1094	24/18367	0.77117923817859	0.909129313082587	SLC15A3	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/1094	24/18367	0.77117923817859	0.909129313082587	PYCARD	1
GO:0120014	phospholipid transfer activity	1/1094	24/18367	0.77117923817859	0.909129313082587	PLTP	1
GO:0015297	antiporter activity	4/1094	89/18367	0.784117960347372	0.920076821879209	SLC8A1/SLC11A1/SLC37A2/CLCN7	4
GO:0003887	DNA-directed DNA polymerase activity	1/1094	25/18367	0.78482640131617	0.920076821879209	POLD4	1
GO:0008327	methyl-CpG binding	1/1094	25/18367	0.78482640131617	0.920076821879209	CXXC5	1
GO:0034237	protein kinase A regulatory subunit binding	1/1094	25/18367	0.78482640131617	0.920076821879209	PJA2	1
GO:0019842	vitamin binding	7/1094	148/18367	0.785313198864235	0.920076821879209	SDS/SDSL/KYNU/P4HA1/RBP7/PDXK/SGPL1	7
GO:0004519	endonuclease activity	6/1094	129/18367	0.787437270504978	0.921427829481164	RNASET2/DNASE2/RNASE6/RNASE1/ERCC1/MBD4	6
GO:0001098	basal transcription machinery binding	3/1094	70/18367	0.795123019257773	0.924564906885644	AHR/ERCC1/DRAP1	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/1094	70/18367	0.795123019257773	0.924564906885644	AHR/ERCC1/DRAP1	3
GO:0004435	phosphatidylinositol phospholipase C activity	1/1094	26/18367	0.797660329838693	0.924564906885644	CCR1	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/1094	26/18367	0.797660329838693	0.924564906885644	GLUL	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/1094	26/18367	0.797660329838693	0.924564906885644	GLUL	1
GO:0030371	translation repressor activity	1/1094	26/18367	0.797660329838693	0.924564906885644	EIF4EBP1	1
GO:0042923	neuropeptide binding	1/1094	26/18367	0.797660329838693	0.924564906885644	SORL1	1
GO:0004222	metalloendopeptidase activity	5/1094	111/18367	0.797912179915008	0.924564906885644	ADAM8/MMP2/ADAM9/ADAM17/ADAM10	5
GO:0015932	nucleobase-containing compound transmembrane transporter activity	2/1094	50/18367	0.807079135148484	0.929008782562865	SLC25A24/SLC25A19	2
GO:0015103	inorganic anion transmembrane transporter activity	7/1094	152/18367	0.80753284822046	0.929008782562865	SLC4A7/ABCC3/LRRC8C/TTYH3/SLC37A2/CLIC1/CLCN7	7
GO:0004518	nuclease activity	10/1094	210/18367	0.808923595184674	0.929008782562865	RNASET2/SAMHD1/DNASE2/PLD3/PLSCR1/RNASE6/RNASE1/TDP2/ERCC1/MBD4	10
GO:0004842	ubiquitin-protein transferase activity	22/1094	433/18367	0.809452214978617	0.929008782562865	RNF130/RNF213/UBE2L6/TRIM22/RNF13/DTX3L/TRIM14/TRIM69/RNF149/RNF145/TRIM38/RNF166/TNFAIP3/RNF135/UBE2W/UBE2D1/PJA2/TTC3/CDC42/UBE3A/XIAP/UBE2D3	22
GO:0008066	glutamate receptor activity	1/1094	27/18367	0.809729442709118	0.929008782562865	PTK2B	1
GO:0051119	sugar transmembrane transporter activity	1/1094	27/18367	0.809729442709118	0.929008782562865	SLC2A3	1
GO:0051393	alpha-actinin binding	1/1094	27/18367	0.809729442709118	0.929008782562865	PDLIM7	1
GO:0051959	dynein light intermediate chain binding	1/1094	27/18367	0.809729442709118	0.929008782562865	CCDC88A	1
GO:0000049	tRNA binding	3/1094	72/18367	0.810557715450002	0.929008782562865	SLFN11/TRMT1/EIF2S3	3
GO:0015370	solute:sodium symporter activity	3/1094	73/18367	0.817899382207409	0.935419250134803	SLC4A7/SLC6A6/SLC1A3	3
GO:0004629	phospholipase C activity	1/1094	28/18367	0.821079278569327	0.935419250134803	CCR1	1
GO:0015101	organic cation transmembrane transporter activity	1/1094	28/18367	0.821079278569327	0.935419250134803	SLC25A19	1
GO:0050681	androgen receptor binding	1/1094	28/18367	0.821079278569327	0.935419250134803	DDX5	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/1094	28/18367	0.821079278569327	0.935419250134803	HERPUD1	1
GO:0008146	sulfotransferase activity	2/1094	52/18367	0.824231915767133	0.936510533184427	GAL3ST4/HS3ST1	2
GO:0031593	polyubiquitin modification-dependent protein binding	2/1094	52/18367	0.824231915767133	0.936510533184427	TNFAIP3/TAB2	2
GO:0005254	chloride channel activity	3/1094	74/18367	0.824997687821055	0.936510533184427	TTYH3/CLIC1/CLCN7	3
GO:0016887	ATP hydrolysis activity	13/1094	272/18367	0.829865917991239	0.937450452401046	RNF213/CHD9/HSPA1A/DDX60L/SLFN11/IFIH1/ATP2C1/RECQL/DDX5/TOR3A/KIF5B/ATP1A1/CHD4	13
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/1094	29/18367	0.831752666935386	0.937450452401046	P2RX7	1
GO:0032452	histone demethylase activity	1/1094	29/18367	0.831752666935386	0.937450452401046	JMJD1C	1
GO:0033612	receptor serine/threonine kinase binding	1/1094	29/18367	0.831752666935386	0.937450452401046	PYCARD	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/1094	29/18367	0.831752666935386	0.937450452401046	OSBPL8	1
GO:0140457	protein demethylase activity	1/1094	29/18367	0.831752666935386	0.937450452401046	JMJD1C	1
GO:0016417	S-acyltransferase activity	1/1094	30/18367	0.841789889226404	0.946443411661801	GLUL	1
GO:0046966	thyroid hormone receptor binding	1/1094	30/18367	0.841789889226404	0.946443411661801	JMJD1C	1
GO:0004867	serine-type endopeptidase inhibitor activity	4/1094	98/18367	0.842723585726261	0.946443411661801	SERPINA1/A2M/SERPINB8/SERPING1	4
GO:0005262	calcium channel activity	5/1094	119/18367	0.844001620037304	0.946632614824063	TRPM2/ORAI2/MCOLN1/ORAI3/TMCO1	5
GO:0003724	RNA helicase activity	3/1094	77/18367	0.844887065074796	0.946632614824063	DDX60L/IFIH1/DDX5	3
GO:0140030	modification-dependent protein binding	7/1094	160/18367	0.846609047514472	0.947443379824569	LAPTM5/LYN/PTPN6/KMT2E/TNFAIP3/TAB2/MORC3	7
GO:0015291	secondary active transmembrane transporter activity	11/1094	240/18367	0.852712352664845	0.953149614462825	SLC8A1/SLC11A1/SLCO2B1/SLC15A3/SLC16A3/SLC4A7/SLC37A2/SLC6A6/MFSD12/SLC1A3/CLCN7	11
GO:0008186	ATP-dependent activity, acting on RNA	3/1094	79/18367	0.857030839173745	0.955725342392343	DDX60L/IFIH1/DDX5	3
GO:0016835	carbon-oxygen lyase activity	3/1094	79/18367	0.857030839173745	0.955725342392343	TBXAS1/HACD4/HSD17B4	3
GO:0001222	transcription corepressor binding	1/1094	32/18367	0.860105120573125	0.955784261620487	STAT1	1
GO:0008175	tRNA methyltransferase activity	1/1094	32/18367	0.860105120573125	0.955784261620487	TRMT1	1
GO:0030515	snoRNA binding	1/1094	32/18367	0.860105120573125	0.955784261620487	NOP10	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	2/1094	57/18367	0.861257948799902	0.955945957205973	NQO2/DHRS4	2
GO:0015293	symporter activity	6/1094	144/18367	0.865028063632302	0.959008916340017	SLC15A3/SLC16A3/SLC4A7/SLC6A6/MFSD12/SLC1A3	6
GO:0005251	delayed rectifier potassium channel activity	1/1094	33/18367	0.868452270728184	0.959442613412161	KCNE3	1
GO:0031369	translation initiation factor binding	1/1094	33/18367	0.868452270728184	0.959442613412161	EIF4EBP1	1
GO:0140323	solute:anion antiporter activity	1/1094	33/18367	0.868452270728184	0.959442613412161	SLC37A2	1
GO:0008201	heparin binding	7/1094	166/18367	0.871518623643963	0.961710667253629	APOE/GPNMB/PTPRC/LPL/HBEGF/VEGFA/VEGFB	7
GO:0015294	solute:cation symporter activity	4/1094	104/18367	0.873864748133583	0.96216517369158	SLC15A3/SLC4A7/SLC6A6/SLC1A3	4
GO:0036002	pre-mRNA binding	2/1094	59/18367	0.873958250497515	0.96216517369158	CELF2/DDX5	2
GO:0008376	acetylgalactosaminyltransferase activity	1/1094	34/18367	0.876301797063046	0.962512043301888	CSGALNACT2	1
GO:0016831	carboxy-lyase activity	1/1094	34/18367	0.876301797063046	0.962512043301888	ME2	1
GO:0008528	G protein-coupled peptide receptor activity	6/1094	147/18367	0.877338526713192	0.962536718902681	CXCR4/FPR3/FPR1/CCR1/CCRL2/AGTRAP	6
GO:0140097	catalytic activity, acting on DNA	10/1094	229/18367	0.881510470252627	0.965997039572452	DNASE2/PLD3/CHD9/POLD4/TDP2/ERCC1/MBD4/RECQL/SETX/CHD4	10
GO:0008135	translation factor activity, RNA binding	3/1094	84/18367	0.883810330474681	0.96740023485637	EIF4G3/EIF2S3/EIF1	3
GO:0000217	DNA secondary structure binding	1/1094	36/18367	0.890624777538232	0.971497602165266	MEF2C	1
GO:0034061	DNA polymerase activity	1/1094	36/18367	0.890624777538232	0.971497602165266	POLD4	1
GO:0042805	actinin binding	1/1094	36/18367	0.890624777538232	0.971497602165266	PDLIM7	1
GO:0005109	frizzled binding	1/1094	37/18367	0.897152326137499	0.976373345762026	SDCBP	1
GO:0030551	cyclic nucleotide binding	1/1094	37/18367	0.897152326137499	0.976373345762026	PRKAR1A	1
GO:0016779	nucleotidyltransferase activity	5/1094	132/18367	0.900178896459242	0.978544985956266	OAS1/OAS2/OAS3/POLD4/PAPSS1	5
GO:0008395	steroid hydroxylase activity	1/1094	38/18367	0.903290643388213	0.978607437083483	CYP27A1	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/1094	38/18367	0.903290643388213	0.978607437083483	DRAP1	1
GO:0008094	ATP-dependent activity, acting on DNA	4/1094	111/18367	0.903329941923215	0.978607437083483	CHD9/RECQL/SETX/CHD4	4
GO:0016758	hexosyltransferase activity	8/1094	197/18367	0.906374872223275	0.980786492291776	TYMP/MGAT4A/MGAT1/COLGALT1/CSGALNACT2/LFNG/HEXA/B3GNT2	8
GO:0019825	oxygen binding	1/1094	39/18367	0.909062918806037	0.98082891668215	SOD2	1
GO:0032451	demethylase activity	1/1094	39/18367	0.909062918806037	0.98082891668215	JMJD1C	1
GO:0043022	ribosome binding	2/1094	66/18367	0.910423257610563	0.98082891668215	TMCO1/OXA1L	2
GO:0099094	ligand-gated cation channel activity	4/1094	113/18367	0.91054823561325	0.98082891668215	P2RX7/TRPM2/PTK2B/MCOLN1	4
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/1094	40/18367	0.914490961518073	0.983959095783051	HMOX1	1
GO:0003713	transcription coactivator activity	11/1094	262/18367	0.916311548024591	0.984204532921244	NUPR1/MTDH/TRIM22/ZMIZ1/CIITA/LMO2/TRIM14/TRIM38/DRAP1/UBE3A/MAML2	11
GO:0003730	mRNA 3'-UTR binding	8/1094	201/18367	0.917053081890197	0.984204532921244	ZFP36L2/ZFP36/ZFP36L1/CELF2/PABPC1/PABPC4/DDX5/ZNF385A	8
GO:0008080	N-acetyltransferase activity	2/1094	68/18367	0.918867456447021	0.984204532921244	SAT1/SAT2	2
GO:0016782	transferase activity, transferring sulphur-containing groups	2/1094	68/18367	0.918867456447021	0.984204532921244	GAL3ST4/HS3ST1	2
GO:0004540	ribonuclease activity	4/1094	116/18367	0.920477528862168	0.984817559064484	RNASET2/SAMHD1/RNASE6/RNASE1	4
GO:0004521	endoribonuclease activity	2/1094	69/18367	0.922803212209035	0.986193973408079	RNASET2/RNASE1	2
GO:0019205	nucleobase-containing compound kinase activity	1/1094	42/18367	0.924395171104169	0.98678404654427	TK2	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/1094	43/18367	0.928908769074812	0.988267289071745	CYP27A1	1
GO:0030547	signaling receptor inhibitor activity	1/1094	43/18367	0.928908769074812	0.988267289071745	LILRB4	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/1094	43/18367	0.928908769074812	0.988267289071745	NCF4	1
GO:0031491	nucleosome binding	2/1094	71/18367	0.930140864779374	0.988458909862844	ACTB/CHD4	2
GO:0022839	ion gated channel activity	1/1094	44/18367	0.933153137478663	0.988458909862844	TTYH3	1
GO:0005230	extracellular ligand-gated ion channel activity	2/1094	73/18367	0.936815502075584	0.988458909862844	P2RX7/PTK2B	2
GO:0035064	methylated histone binding	2/1094	73/18367	0.936815502075584	0.988458909862844	KMT2E/MORC3	2
GO:0140034	methylation-dependent protein binding	2/1094	73/18367	0.936815502075584	0.988458909862844	KMT2E/MORC3	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/1094	45/18367	0.93714432165147	0.988458909862844	NQO2	1
GO:0140223	general transcription initiation factor activity	1/1094	45/18367	0.93714432165147	0.988458909862844	DRAP1	1
GO:0051082	unfolded protein binding	4/1094	122/18367	0.937421516202908	0.988458909862844	HSPA1A/TAPBP/CANX/PFDN5	4
GO:0005272	sodium channel activity	1/1094	46/18367	0.940897411495007	0.99102291177443	TRPM2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	6/1094	170/18367	0.943761961436387	0.992938028163117	HMOX1/TBXAS1/CYP27A1/SCD/PTGS1/P4HA1	6
GO:0004497	monooxygenase activity	3/1094	102/18367	0.946917346613034	0.994922811579057	HMOX1/TBXAS1/CYP27A1	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/1094	48/18367	0.947745228311346	0.994922811579057	GLUL	1
GO:0034987	immunoglobulin receptor binding	2/1094	79/18367	0.953392897705348	0.999745701571686	FLNA/FGR	2
GO:0015079	potassium ion transmembrane transporter activity	5/1094	155/18367	0.95760128621472	0.999891108224789	KCNAB2/KCNE3/ATP1B1/ATP1B3/ATP1A1	5
GO:0046873	metal ion transmembrane transporter activity	18/1094	430/18367	0.958670179328256	0.999891108224789	SLC8A1/SLC11A1/SLC4A7/KCNAB2/KCNE3/TRPM2/SLC6A6/ORAI2/ATP1B1/ATP2C1/SLC31A1/MCOLN1/SLC30A1/ORAI3/TMCO1/SLC1A3/ATP1B3/ATP1A1	18
GO:0005244	voltage-gated ion channel activity	7/1094	201/18367	0.958840458901671	0.999891108224789	CYBB/KCNAB2/HVCN1/KCNE3/PTK2B/CLIC1/CLCN7	7
GO:0022832	voltage-gated channel activity	7/1094	201/18367	0.958840458901671	0.999891108224789	CYBB/KCNAB2/HVCN1/KCNE3/PTK2B/CLIC1/CLCN7	7
GO:0017046	peptide hormone binding	1/1094	52/18367	0.959154257905027	0.999891108224789	PIK3R1	1
GO:0050661	NADP binding	1/1094	53/18367	0.961594074549958	0.999891108224789	DPYD	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/1094	54/18367	0.963888280209144	0.999891108224789	P4HA1	1
GO:0004843	thiol-dependent deubiquitinase	3/1094	113/18367	0.967873559580992	0.999891108224789	OTUD1/TNFAIP3/USP3	3
GO:0030374	nuclear receptor coactivator activity	1/1094	56/18367	0.968074072264844	0.999891108224789	ZMIZ1	1
GO:0101005	deubiquitinase activity	3/1094	114/18367	0.969330292552157	0.999891108224789	OTUD1/TNFAIP3/USP3	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/1094	59/18367	0.973461568257662	0.999891108224789	PLD3	1
GO:0005249	voltage-gated potassium channel activity	2/1094	90/18367	0.973597806445436	0.999891108224789	KCNAB2/KCNE3	2
GO:0015276	ligand-gated ion channel activity	4/1094	143/18367	0.974004214146517	0.999891108224789	P2RX7/TRPM2/PTK2B/MCOLN1	4
GO:0022834	ligand-gated channel activity	4/1094	143/18367	0.974004214146517	0.999891108224789	P2RX7/TRPM2/PTK2B/MCOLN1	4
GO:0022843	voltage-gated cation channel activity	4/1094	143/18367	0.974004214146517	0.999891108224789	KCNAB2/HVCN1/KCNE3/PTK2B	4
GO:0022824	transmitter-gated ion channel activity	1/1094	60/18367	0.97504738016099	0.999891108224789	PTK2B	1
GO:0022835	transmitter-gated channel activity	1/1094	60/18367	0.97504738016099	0.999891108224789	PTK2B	1
GO:0016410	N-acyltransferase activity	2/1094	94/18367	0.978589619139298	0.999891108224789	SAT1/SAT2	2
GO:0005179	hormone activity	3/1094	122/18367	0.978927954114233	0.999891108224789	HAMP/RETN/METRNL	3
GO:0015267	channel activity	19/1094	480/18367	0.98067648139784	0.999891108224789	CYBB/P2RX7/AQP9/ATP6V1A/KCNAB2/HVCN1/LRRC8C/KCNE3/TTYH3/TRPM2/ORAI2/TMC6/PTK2B/MCOLN1/ORAI3/TMCO1/CLIC1/CLCN7/BAX	19
GO:0022803	passive transmembrane transporter activity	19/1094	481/18367	0.981180576084027	0.999891108224789	CYBB/P2RX7/AQP9/ATP6V1A/KCNAB2/HVCN1/LRRC8C/KCNE3/TTYH3/TRPM2/ORAI2/TMC6/PTK2B/MCOLN1/ORAI3/TMCO1/CLIC1/CLCN7/BAX	19
GO:0008173	RNA methyltransferase activity	1/1094	65/18367	0.981664278405455	0.999891108224789	TRMT1	1
GO:0008170	N-methyltransferase activity	2/1094	97/18367	0.981720425223078	0.999891108224789	HNMT/TRMT1	2
GO:0019783	ubiquitin-like protein-specific protease activity	3/1094	125/18367	0.981727036867884	0.999891108224789	OTUD1/TNFAIP3/USP3	3
GO:0008242	omega peptidase activity	3/1094	126/18367	0.982578408229128	0.999891108224789	OTUD1/TNFAIP3/USP3	3
GO:0022836	gated channel activity	12/1094	340/18367	0.984399388645626	0.999891108224789	CYBB/P2RX7/KCNAB2/HVCN1/KCNE3/TTYH3/TRPM2/TMC6/PTK2B/MCOLN1/CLIC1/CLCN7	12
GO:0003684	damaged DNA binding	1/1094	68/18367	0.984759857809422	0.999891108224789	ERCC1	1
GO:0019843	rRNA binding	1/1094	68/18367	0.984759857809422	0.999891108224789	GTF3A	1
GO:0003777	microtubule motor activity	1/1094	69/18367	0.985670984950604	0.999891108224789	KIF5B	1
GO:0005216	ion channel activity	16/1094	432/18367	0.987077372926229	0.999891108224789	P2RX7/ATP6V1A/KCNAB2/HVCN1/LRRC8C/KCNE3/TTYH3/TRPM2/ORAI2/TMC6/PTK2B/MCOLN1/ORAI3/TMCO1/CLIC1/CLCN7	16
GO:0070063	RNA polymerase binding	1/1094	73/18367	0.988802771923412	0.999891108224789	ZFP36	1
GO:0016874	ligase activity	4/1094	165/18367	0.990196833504003	0.999891108224789	GLUL/ATP6V1A/ACSL1/ACSL4	4
GO:0005261	cation channel activity	11/1094	335/18367	0.991098014578392	0.999891108224789	P2RX7/ATP6V1A/KCNAB2/HVCN1/KCNE3/TRPM2/ORAI2/PTK2B/MCOLN1/ORAI3/TMCO1	11
GO:0030594	neurotransmitter receptor activity	2/1094	111/18367	0.991339170378215	0.999891108224789	TSPO/PTK2B	2
GO:0042393	histone binding	7/1094	244/18367	0.991652211660238	0.999891108224789	STAT1/PARP9/DTX3L/JAK2/KMT2E/USP3/MORC3	7
GO:0004527	exonuclease activity	1/1094	80/18367	0.992728613781821	0.999891108224789	PLD3	1
GO:0005201	extracellular matrix structural constituent	4/1094	172/18367	0.992882099779192	0.999891108224789	TGFBI/FGL2/CD4/EMILIN2	4
GO:0005267	potassium channel activity	2/1094	121/18367	0.99496113362988	0.999891108224789	KCNAB2/KCNE3	2
GO:0003735	structural constituent of ribosome	3/1094	182/18367	0.99894179126047	0.999891108224789	ISG15/RPS27L/MRPL41	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/1094	156/18367	0.999273228022699	0.999891108224789	HNMT/TRMT1	2
GO:0140101	catalytic activity, acting on a tRNA	1/1094	124/18367	0.999519835502226	0.999891108224789	TRMT1	1
GO:0008168	methyltransferase activity	3/1094	214/18367	0.999803682390207	0.999891108224789	HNMT/PRDM1/TRMT1	3
GO:0140098	catalytic activity, acting on RNA	9/1094	386/18367	0.999805515218322	0.999891108224789	RNASET2/SAMHD1/RNASE6/DDX60L/RNASE1/IFIH1/TDP2/TRMT1/DDX5	9
GO:0016741	transferase activity, transferring one-carbon groups	3/1094	225/18367	0.999891108224789	0.999891108224789	HNMT/PRDM1/TRMT1	3