ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003779	actin binding	62/922	440/18367	1.52452704165339e-13	1.33243663440506e-10	S100A4/AIF1/LCP1/TMSB4X/COTL1/CORO1A/GMFG/LSP1/LRRK2/MSN/FLNA/FXYD5/MYO1F/GBP1/ACTR2/MARCKS/WAS/TMSB10/TPM3/FMNL1/IQGAP1/RCSD1/VASP/WIPF1/CAP1/PARVG/MYO1G/ARPC1B/ARPC3/CCDC88A/CAPG/CXCR4/PPP1R18/PHACTR1/GAS7/PSTPIP1/FGD4/CNN2/MSRB1/HCLS1/ACTR3/FKBP15/ARPC4/CFL1/CAPZA1/TLN1/SHTN1/CAPZA2/TWF2/DIAPH1/PFN1/DBNL/ARPC5/FLII/SSH2/CORO1C/HNRNPU/EEF2/MYO9B/MYH9/PLEC/BLOC1S6	62
GO:0140375	immune receptor activity	30/922	144/18367	2.25207963932516e-11	9.84158802385096e-09	FCER1G/HLA-DRA/CD74/CD44/FPR1/HLA-DPA1/C5AR1/HLA-DRB1/LILRB3/LILRB2/HLA-DQB1/IFNGR2/IL17RA/LILRB1/CX3CR1/CCR1/IL10RA/CTSH/CD4/CCR2/CXCR4/LILRA5/LILRA2/IL6R/FCGR1B/HLA-DQA1/IL13RA1/CSF2RB/IFNGR1/IFNAR1	30
GO:0035325	Toll-like receptor binding	9/922	12/18367	3.73992110464813e-10	1.08956368182082e-07	S100A9/S100A8/CD36/LY96/TLR2/SYK/MYD88/TLR1/UNC93B1	9
GO:0051020	GTPase binding	41/922	291/18367	2.16296976544883e-09	4.72608893750569e-07	LCP1/NCF2/ARHGDIB/LRRK2/FLNA/DMXL2/WAS/FMNL1/IQGAP1/SORL1/RIN3/FGD2/DOCK11/FGD4/RASSF5/AKAP13/PKN1/RAP1A/C9orf72/PICALM/PAK1/PAK2/DIAPH1/GDI2/ROCK1/PFN1/GNB2/RAB11FIP1/MAP3K11/BICD2/GNB1/YBX1/BRK1/MYCBP2/CORO1C/MYO9B/LAMTOR1/RABGAP1L/CDC42SE1/ARHGDIA/CIB1	41
GO:0051015	actin filament binding	34/922	217/18367	3.32124961854317e-09	5.80554433321347e-07	AIF1/LCP1/COTL1/CORO1A/FLNA/MYO1F/ACTR2/MARCKS/TPM3/FMNL1/IQGAP1/RCSD1/MYO1G/ARPC1B/ARPC3/CAPG/GAS7/PSTPIP1/HCLS1/ACTR3/ARPC4/CFL1/CAPZA1/TLN1/SHTN1/CAPZA2/TWF2/DBNL/ARPC5/FLII/CORO1C/EEF2/MYH9/BLOC1S6	34
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	41/922	299/18367	4.85782743776377e-09	7.07623530100923e-07	FOS/NFKBIA/SPI1/KLF4/ACTB/STAT1/MTDH/NR4A1/CEBPB/NR4A2/LMO2/PRKCB/NOTCH2/PARP9/JUN/FBP1/HCLS1/JMJD1C/MEF2A/JUND/PKN1/DTX3L/DDX5/STAT3/RB1/RXRA/HIF1A/COMMD6/CTBP2/ZBTB7A/ARID1A/SPEN/PTPN2/SP1/TAF10/ETS2/CREBBP/EP300/SP3/CREB1/TRIP12	41
GO:0023023	MHC protein complex binding	13/922	36/18367	9.30105769000355e-09	1.01614055263289e-06	HLA-DRA/CD74/HLA-DPA1/B2M/HLA-DPB1/HLA-DRB1/LILRB2/HLA-DQB1/HLA-DMA/HLA-DMB/LILRB1/CD4/HLA-DQA1	13
GO:0042605	peptide antigen binding	13/922	36/18367	9.30105769000355e-09	1.01614055263289e-06	HLA-B/HLA-C/HLA-A/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DQB1/HLA-F/HLA-DQA1/TAP1/TAPBP	13
GO:0038187	pattern recognition receptor activity	11/922	26/18367	1.85436861500108e-08	1.80079796612327e-06	FCN1/CD14/CLEC7A/CD36/CLEC4E/LY96/TLR2/TLR8/TLR4/PTAFR/CARD8	11
GO:0031267	small GTPase binding	36/922	259/18367	2.95010259993674e-08	2.37372345561549e-06	NCF2/ARHGDIB/LRRK2/FLNA/DMXL2/WAS/FMNL1/IQGAP1/SORL1/RIN3/FGD2/DOCK11/FGD4/RASSF5/AKAP13/PKN1/RAP1A/C9orf72/PICALM/PAK1/PAK2/DIAPH1/GDI2/ROCK1/PFN1/RAB11FIP1/MAP3K11/BICD2/BRK1/MYCBP2/CORO1C/MYO9B/RABGAP1L/CDC42SE1/ARHGDIA/CIB1	36
GO:0023026	MHC class II protein complex binding	11/922	27/18367	2.98752379997373e-08	2.37372345561549e-06	HLA-DRA/CD74/HLA-DPA1/B2M/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DMA/HLA-DMB/CD4/HLA-DQA1	11
GO:0140297	DNA-binding transcription factor binding	45/922	394/18367	2.33109259166907e-07	1.69781243759897e-05	FOS/NFKBIA/SPI1/KLF4/ACTB/STAT1/MTDH/NR4A1/MEF2C/CEBPB/NR4A2/LMO2/PRKCB/NOTCH2/NLRP3/PARP9/HHEX/JUN/FBP1/HCLS1/JMJD1C/MEF2A/JUND/PKN1/DTX3L/DDX5/STAT3/RB1/RXRA/HIF1A/COMMD6/CTBP2/ZBTB7A/ARID1A/SPEN/PTPN2/SP1/TAF10/ETS2/CREBBP/EP300/USF2/SP3/CREB1/TRIP12	45
GO:0005126	cytokine receptor binding	34/922	271/18367	8.31894910517554e-07	5.59289347532571e-05	IL1B/CCL3L3/PYCARD/TNFSF13B/CCL3/TNFSF10/STAT1/CXCL8/USP15/JAK2/CX3CR1/IL1RN/TGFB1/SYK/CCR2/CCDC88A/BID/TNF/MYD88/IL6R/CD300LF/CCL4/SH2B3/JAK1/FKBP1A/IL13RA1/CKLF/ITGA5/GRB2/STAT3/CFLAR/SDCBP/TGFBR2/ADAM17	34
GO:0003924	GTPase activity	39/922	337/18367	1.06335561364139e-06	6.63837718801838e-05	RGS2/ARHGDIB/LRRK2/RHOB/TUBA1A/GNAI2/GBP1/RAC2/GBP2/GIMAP7/MX1/RAB32/RGS18/GBP4/MX2/GBP5/RGS19/RHOA/RAB27A/GCH1/RHOG/RGS10/RALB/RAB8B/RAP1A/RHOQ/CDC42/GNAQ/RRAS/EIF2S3/GNB2/RAP1B/GNB1/EEF2/RAB10/GNAI3/RAP2B/DDX3X/GNA13	39
GO:0030695	GTPase regulator activity	50/922	488/18367	1.37321254497248e-06	7.50117352691218e-05	RGS2/ARHGDIB/LRRK2/SMAP2/GPSM3/WAS/ACAP2/IQGAP1/RGS18/NCKAP1L/DOCK2/CCDC88A/TAGAP/ARHGAP26/ARHGAP30/RIN3/FGD2/DOCK11/ALDH1A1/FGD4/RCBTB2/RASGRP2/CYTH4/ARHGAP4/PREX1/JUN/LAMTOR4/AKAP13/RGS10/ARAP1/CYTH1/ADAP2/RAP1A/C9orf72/DOCK8/ITSN2/GNAQ/SIRPA/GDI2/RASGEF1B/ARHGEF3/GIT2/BNIP2/MYCBP2/MYO9B/LAMTOR1/RABGAP1L/CDC42SE1/ARHGDIA/GNA13	50
GO:0060589	nucleoside-triphosphatase regulator activity	50/922	488/18367	1.37321254497248e-06	7.50117352691218e-05	RGS2/ARHGDIB/LRRK2/SMAP2/GPSM3/WAS/ACAP2/IQGAP1/RGS18/NCKAP1L/DOCK2/CCDC88A/TAGAP/ARHGAP26/ARHGAP30/RIN3/FGD2/DOCK11/ALDH1A1/FGD4/RCBTB2/RASGRP2/CYTH4/ARHGAP4/PREX1/JUN/LAMTOR4/AKAP13/RGS10/ARAP1/CYTH1/ADAP2/RAP1A/C9orf72/DOCK8/ITSN2/GNAQ/SIRPA/GDI2/RASGEF1B/ARHGEF3/GIT2/BNIP2/MYCBP2/MYO9B/LAMTOR1/RABGAP1L/CDC42SE1/ARHGDIA/GNA13	50
GO:0019955	cytokine binding	22/922	139/18367	1.62428880440438e-06	8.3507553826437e-05	ZFP36/CD74/TNFRSF1B/CD36/GBP1/PLP2/ITGA4/CX3CR1/CCR1/IL1RN/IL10RA/CD4/CCR2/CSF1R/CXCR4/TNFRSF14/IL6R/IL13RA1/IFNGR1/TNFRSF1A/TGFBR2/IFNAR1	22
GO:0017124	SH3 domain binding	21/922	130/18367	1.98739680555545e-06	9.64991560030815e-05	CYBA/NCF1/LYN/SH3BGRL/WAS/PTPN6/GPX1/VASP/WIPF1/PLSCR1/SH3BP2/INPP5D/HCLS1/SH3KBP1/GRB2/SIRPA/ZNF106/ADAM10/ABI1/QKI/ADAM17	21
GO:0044389	ubiquitin-like protein ligase binding	36/922	316/18367	3.94001654634329e-06	0.000175886394660244	TXNIP/LAPTM5/NFKBIA/TNFRSF1B/LYN/ISG15/STAT1/ARRB2/CEBPB/UBE2L6/STAT2/BID/CXCR4/TNFRSF14/PARP9/JUN/PTK2B/UBE2D1/JAK1/HSPA1A/RALB/TRIB1/DTX3L/GABARAP/CDKN1A/SPOPL/PRKACA/PRKAR1A/RB1/HIF1A/TANK/PIAS1/PCBP2/LTBR/TMBIM6/SPOP	36
GO:0019887	protein kinase regulator activity	27/922	204/18367	4.02486028970811e-06	0.000175886394660244	GMFG/SOCS3/RAC2/DAZAP2/CCNL1/IQGAP1/MOB1A/NCKAP1L/CALM2/MOB3A/TRIB1/STK4/CHP1/PRKAG2/TAOK3/CCNI/PAK2/CDKN1A/PRKAR1A/CCNY/YWHAB/CAB39/ABI1/TAOK1/DDX3X/WNK1/CIB1	27
GO:0019864	IgG binding	6/922	11/18367	5.85257592902181e-06	0.000232506880089321	FCER1G/FCGRT/FCGR2A/FCGR3A/FCGR1A/FCGR1B	6
GO:0042608	T cell receptor binding	6/922	11/18367	5.85257592902181e-06	0.000232506880089321	HLA-A/HLA-DRA/HLA-DRB1/HLA-E/DOCK2/FYN	6
GO:0005096	GTPase activator activity	46/922	462/18367	7.72836674714197e-06	0.000293677936391395	RGS2/ARHGDIB/LRRK2/SMAP2/ACAP2/IQGAP1/RGS18/NCKAP1L/DOCK2/CCDC88A/TAGAP/ARHGAP26/ARHGAP30/RIN3/FGD2/DOCK11/ALDH1A1/FGD4/RCBTB2/RASGRP2/CYTH4/ARHGAP4/PREX1/JUN/LAMTOR4/AKAP13/RGS10/ARAP1/CYTH1/ADAP2/RAP1A/C9orf72/DOCK8/ITSN2/GNAQ/GDI2/RASGEF1B/ARHGEF3/GIT2/BNIP2/MYCBP2/MYO9B/LAMTOR1/RABGAP1L/ARHGDIA/GNA13	46
GO:0004715	non-membrane spanning protein tyrosine kinase activity	11/922	45/18367	1.01263978737751e-05	0.000368769655903309	LYN/FGR/HCK/JAK2/SYK/CSK/FYN/BTK/PTK2B/JAK1/CLK1	11
GO:0042277	peptide binding	35/922	321/18367	1.40062548125182e-05	0.000489658668245635	ITGB2/CD14/HLA-B/CST3/HLA-C/HLA-A/HLA-DRA/CD74/NFKBIA/CRIP1/HLA-DPA1/HLA-DPB1/CD36/HLA-DRB1/NUP214/HLA-E/LILRB2/HLA-DQB1/TPP1/HLA-F/TLR2/SORL1/ITGAM/PFDN5/TLR4/MGST1/HLA-DQA1/TAP1/TLR1/TAPBP/PICALM/RXRA/LNPEP/PPP3CA/PRNP	35
GO:0005525	GTP binding	39/922	377/18367	1.58096051055039e-05	0.000531445956238863	SAMHD1/GIMAP4/LRRK2/RHOB/TUBA1A/GNAI2/GBP1/RAC2/GBP2/IFI44L/GIMAP7/MX1/RAB32/GBP4/MX2/GBP5/RHOA/GIMAP1/RAB27A/GIMAP8/GCH1/GIMAP2/RHOG/NUDT16/RALB/RAB8B/NIN/RAP1A/RHOQ/CDC42/GNAQ/RRAS/EIF2S3/RAP1B/EEF2/RAB10/GNAI3/RAP2B/GNA13	39
GO:0019207	kinase regulator activity	28/922	233/18367	1.71543484608636e-05	0.000555292613140549	GMFG/KLF4/SOCS3/RAC2/DAZAP2/CCNL1/IQGAP1/MOB1A/NCKAP1L/CALM2/MOB3A/TRIB1/STK4/CHP1/PRKAG2/TAOK3/CCNI/PAK2/CDKN1A/PRKAR1A/CCNY/YWHAB/CAB39/ABI1/TAOK1/DDX3X/WNK1/CIB1	28
GO:0019001	guanyl nucleotide binding	40/922	398/18367	2.41623335712293e-05	0.000728202742801876	SAMHD1/GIMAP4/LRRK2/RHOB/TUBA1A/GNAI2/GBP1/RAC2/GBP2/IFI44L/GIMAP7/MX1/RAB32/GBP4/MX2/GBP5/RHOA/GIMAP1/RAB27A/GIMAP8/GCH1/GIMAP2/RHOG/NUDT16/RALB/RAB8B/NIN/RAP1A/RHOQ/CDC42/GNAQ/RRAS/EIF2S3/RAP1B/EEF2/RAB10/GNAI3/RAP2B/GNA13/DYNC1LI1	40
GO:0032561	guanyl ribonucleotide binding	40/922	398/18367	2.41623335712293e-05	0.000728202742801876	SAMHD1/GIMAP4/LRRK2/RHOB/TUBA1A/GNAI2/GBP1/RAC2/GBP2/IFI44L/GIMAP7/MX1/RAB32/GBP4/MX2/GBP5/RHOA/GIMAP1/RAB27A/GIMAP8/GCH1/GIMAP2/RHOG/NUDT16/RALB/RAB8B/NIN/RAP1A/RHOQ/CDC42/GNAQ/RRAS/EIF2S3/RAP1B/EEF2/RAB10/GNAI3/RAP2B/GNA13/DYNC1LI1	40
GO:0033218	amide binding	40/922	400/18367	2.70992306121768e-05	0.000789490918501416	ITGB2/CD14/HLA-B/CST3/HLA-C/HLA-A/HLA-DRA/CD74/NFKBIA/CRIP1/HLA-DPA1/HLA-DPB1/CD36/HLA-DRB1/NUP214/HLA-E/LILRB2/PSAP/HLA-DQB1/TPP1/HLA-F/TLR2/SORL1/ITGAM/PFDN5/FKBP5/TLR4/MGST1/CD300LF/HLA-DQA1/TAP1/TLR1/TAPBP/FKBP1A/PICALM/RXRA/LNPEP/NQO2/PPP3CA/PRNP	40
GO:0045296	cadherin binding	35/922	332/18367	2.86803722227946e-05	0.000808601462023306	FLNA/FXYD5/EFHD2/STAT1/LRRFIP1/IQGAP1/VASP/NUMB/CAPG/CNN2/HSPA1A/AHNAK/CAPZA1/TLN1/SHTN1/PICALM/PAK2/TWF2/CLIC1/EIF2S3/YWHAB/STK38/CAST/PFN1/DBNL/TMPO/TAGLN2/EEF2/TES/MYH9/RAB10/ABI1/SNX2/DDX3X/PLEC	35
GO:0030295	protein kinase activator activity	16/922	101/18367	4.12576139535951e-05	0.00112684858110757	DAZAP2/IQGAP1/MOB1A/NCKAP1L/CALM2/MOB3A/STK4/PRKAG2/PAK2/CDKN1A/CCNY/CAB39/ABI1/TAOK1/DDX3X/WNK1	16
GO:0001784	phosphotyrosine residue binding	10/922	44/18367	5.04984265891045e-05	0.00133744317693568	FGR/HCK/SOCS3/PTPN6/SYK/SH3BP2/SAMSN1/GRB2/PFN1/MAPK1	10
GO:0032395	MHC class II receptor activity	5/922	10/18367	6.43140479779388e-05	0.00156140216479774	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DQB1/HLA-DQA1	5
GO:0050786	RAGE receptor binding	5/922	10/18367	6.43140479779388e-05	0.00156140216479774	S100A9/S100A4/S100A8/S100A12/FPR1	5
GO:0070008	serine-type exopeptidase activity	5/922	10/18367	6.43140479779388e-05	0.00156140216479774	TPP1/CPVL/SCPEP1/PRCP/CTSA	5
GO:0003725	double-stranded RNA binding	13/922	74/18367	7.1649675253146e-05	0.00169248151814188	VIM/MSN/MTDH/MBNL1/LRRFIP1/TLR8/OAS1/OAS2/IFIH1/ADAR/HNRNPU/DICER1/DDX21	13
GO:0019003	GDP binding	13/922	75/18367	8.27469772172092e-05	0.00189213927163465	RHOB/GBP1/RHOA/RAB27A/RALB/RAB8B/RAP1A/RRAS/RAP1B/RAB10/GNAI3/RAP2B/DYNC1LI1	13
GO:0019209	kinase activator activity	16/922	107/18367	8.44318439287771e-05	0.00189213927163465	DAZAP2/IQGAP1/MOB1A/NCKAP1L/CALM2/MOB3A/STK4/PRKAG2/PAK2/CDKN1A/CCNY/CAB39/ABI1/TAOK1/DDX3X/WNK1	16
GO:0045309	protein phosphorylated amino acid binding	11/922	56/18367	8.96080948144037e-05	0.00195793687169472	FGR/HCK/SOCS3/PTPN6/SYK/SH3BP2/SAMSN1/GRB2/YWHAB/PFN1/MAPK1	11
GO:0004896	cytokine receptor activity	15/922	97/18367	9.44534219548455e-05	0.00197057890924251	CD74/CD44/IFNGR2/IL17RA/CX3CR1/CCR1/IL10RA/CD4/CCR2/CXCR4/IL6R/IL13RA1/CSF2RB/IFNGR1/IFNAR1	15
GO:0019865	immunoglobulin binding	7/922	23/18367	9.47824587317993e-05	0.00197057890924251	FCER1G/FCGRT/FCGR2A/FCGR3A/FCGR1A/LILRA2/FCGR1B	7
GO:0031625	ubiquitin protein ligase binding	31/922	297/18367	9.69506786011761e-05	0.00197057890924251	TXNIP/LAPTM5/NFKBIA/TNFRSF1B/LYN/ISG15/ARRB2/UBE2L6/BID/CXCR4/TNFRSF14/JUN/PTK2B/UBE2D1/JAK1/HSPA1A/RALB/TRIB1/GABARAP/CDKN1A/SPOPL/PRKACA/PRKAR1A/RB1/HIF1A/TANK/PIAS1/PCBP2/LTBR/TMBIM6/SPOP	31
GO:0005178	integrin binding	19/922	144/18367	0.000108999254246273	0.00211700773802761	IL1B/LCP1/ITGB2/JAML/LYN/ISG15/ITGA4/ICAM3/FERMT3/TGFBI/SYK/ITGAM/ITGAX/TIMP2/TLN1/ADAM10/MYH9/PTPN2/ADAM17	19
GO:0016922	nuclear receptor binding	19/922	144/18367	0.000108999254246273	0.00211700773802761	STAT1/NR4A1/CEBPB/NR4A2/PRKCB/JMJD1C/JUND/PKN1/DDX5/STAT3/RXRA/HIF1A/CTBP2/ZBTB7A/ARID1A/TAF10/ETS2/EP300/TRIP12	19
GO:0032393	MHC class I receptor activity	6/922	17/18367	0.000120837459285614	0.00229591172642666	LILRB3/LILRB2/LILRB1/CTSH/LILRA5/LILRA2	6
GO:0042287	MHC protein binding	9/922	40/18367	0.000130246849606719	0.00237157805325568	CD74/CLEC7A/HLA-E/LILRB2/PILRA/LILRB1/CD4/TAP1/TAPBP	9
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	9/922	40/18367	0.000130246849606719	0.00237157805325568	PYCARD/CASP1/NAIP/CTSH/BIRC3/APAF1/RPS6KA3/CARD8/BIRC2	9
GO:0019902	phosphatase binding	23/922	196/18367	0.000135487819640731	0.00241666029318365	STAT1/LILRB2/LILRB1/IQGAP1/SYK/CSK/C20orf27/STAT6/PPP1R18/CD33/PHACTR1/EIF4EBP1/JAK1/PPP1R15A/GRB2/STAT3/SIRPA/MAPK1/BOD1L1/IRS2/SHOC2/MVP/WNK1	23
GO:0035035	histone acetyltransferase binding	7/922	25/18367	0.000170177648356591	0.00291637773850315	EGR1/STAT1/CEBPB/MEF2A/ZBTB7A/SP1/CREB1	7
GO:0051019	mitogen-activated protein kinase binding	7/922	25/18367	0.000170177648356591	0.00291637773850315	DUSP1/ARRB2/IQGAP1/PTAFR/GCH1/MAPKAPK3/NBR1	7
GO:0031435	mitogen-activated protein kinase kinase kinase binding	6/922	18/18367	0.000173584158144275	0.00291754911957878	DAZAP2/CDC42/STK38/MAPK1/MAP3K11/TGFBR2	6
GO:0032396	inhibitory MHC class I receptor activity	5/922	12/18367	0.000185764132990892	0.00298601020758248	LILRB3/LILRB2/LILRB1/LILRA5/LILRA2	5
GO:0097677	STAT family protein binding	5/922	12/18367	0.000185764132990892	0.00298601020758248	SPI1/PARP9/DTX3L/PTPN2/EP300	5
GO:0019903	protein phosphatase binding	19/922	150/18367	0.000187906820843291	0.00298601020758248	STAT1/LILRB2/LILRB1/IQGAP1/CSK/C20orf27/STAT6/CD33/PHACTR1/EIF4EBP1/JAK1/PPP1R15A/GRB2/STAT3/SIRPA/BOD1L1/IRS2/SHOC2/MVP	19
GO:0070851	growth factor receptor binding	18/922	141/18367	0.000249009391232045	0.00388632514172871	IL1B/PYCARD/LYN/JAK2/IL1RN/PLSCR1/HBEGF/CCDC88A/MYD88/IL6R/CD300LF/FYN/ITGA5/GRB2/SDCBP/PTEN/ADAM17/SNX2	18
GO:0004674	protein serine/threonine kinase activity	36/922	386/18367	0.000270124869329648	0.0041419146630546	CCL3/LRRK2/IRAK3/STK17B/PRKCB/MAP3K1/SYK/MAP3K3/PTK2B/AKAP13/MAPKAPK3/STK10/PKN1/STK4/PRKAG2/PAK1/TAOK3/SGK1/RPS6KA3/PAK2/PRKACA/MAP3K2/ROCK1/STK38/HIPK3/MAPK1/BMP2K/MAP3K11/ATM/MAP3K8/TGFBR2/CLK1/TAOK1/HIPK1/WNK1/SMG1	36
GO:0042288	MHC class I protein binding	6/922	20/18367	0.000332440226427473	0.0050095303085795	HLA-E/LILRB2/PILRA/LILRB1/TAP1/TAPBP	6
GO:0003953	NAD+ nucleosidase activity	7/922	28/18367	0.000367390647329265	0.00544236314857249	TLR2/PIK3AP1/BST1/TLR8/MYD88/TLR4/TLR1	7
GO:0051219	phosphoprotein binding	13/922	88/18367	0.00043014732719852	0.00618456055467056	LYN/FGR/HCK/SOCS3/PTPN6/SYK/SH3BP2/SAMSN1/GRB2/YWHAB/RB1/PFN1/MAPK1	13
GO:0035259	glucocorticoid receptor binding	5/922	14/18367	0.000431645530703552	0.00618456055467056	NR4A1/CEBPB/NR4A2/STAT3/ETS2	5
GO:0001221	transcription coregulator binding	12/922	78/18367	0.000485412091201335	0.00684274464048333	KLF4/STAT1/LMO2/AHR/HIF1A/CTBP2/ZBTB7A/SP1/CREBBP/EP300/FAM89B/CREB1	12
GO:0061134	peptidase regulator activity	24/922	230/18367	0.000573446669653278	0.00795543475042801	SERPINA1/CST3/PYCARD/CARD16/CSTA/TIMP1/CASP1/BST2/NAIP/CTSH/BIRC3/APAF1/PSME2/SERPINB1/TIMP2/PSME1/RPS6KA3/CSTB/ROCK1/CAST/CARD8/TANK/PRNP/BIRC2	24
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	5/922	15/18367	0.000620823226917878	0.00847811719259727	CYBB/CYBA/NCF1/NCF2/CYB5R4	5
GO:0004860	protein kinase inhibitor activity	11/922	70/18367	0.000686637953336244	0.00912185929906729	GMFG/SOCS3/TRIB1/CHP1/PRKAG2/TAOK3/CDKN1A/PRKAR1A/YWHAB/WNK1/CIB1	11
GO:0035591	signaling adaptor activity	12/922	81/18367	0.000688836056908971	0.00912185929906729	LRRK2/DOK2/IQGAP1/PAG1/SH2B3/AKAP13/STAT3/GNB4/GNB2/GNB1/ABI1/NUP62	12
GO:0003925	G protein activity	8/922	40/18367	0.000717220523685869	0.0092183932014919	RHOA/RAB27A/RALB/RAP1A/CDC42/RAP1B/RAB10/RAP2B	8
GO:0042169	SH2 domain binding	8/922	40/18367	0.000717220523685869	0.0092183932014919	PTPN6/LILRB1/JAK2/SYK/LAT2/CCDC88A/PAG1/NUP62	8
GO:0001216	DNA-binding transcription activator activity	39/922	456/18367	0.000851024312260366	0.0106841742097767	FOS/JUNB/KLF6/IRF1/FOSB/SPI1/EGR1/KLF4/CEBPD/MAFB/NR4A1/MEF2C/CEBPB/NR4A2/BACH1/TFEC/PLSCR1/STAT6/FLI1/HHEX/JUN/ELK3/REL/MEF2A/JUND/ELF1/LITAF/STAT3/FOSL2/KLF10/HIF1A/IRF2/CREBRF/ATF3/SP1/NR3C1/EP300/NFKB1/CREB1	39
GO:0005521	lamin binding	5/922	16/18367	0.000865902767430933	0.0106841742097767	BNIP3L/SUN2/TMPO/LBR/PRNP	5
GO:0005085	guanyl-nucleotide exchange factor activity	23/922	223/18367	0.00086793634884914	0.0106841742097767	DOCK2/CCDC88A/TAGAP/RIN3/FGD2/DOCK11/FGD4/RCBTB2/RASGRP2/CYTH4/PREX1/LAMTOR4/AKAP13/CYTH1/RAP1A/C9orf72/DOCK8/ITSN2/RASGEF1B/ARHGEF3/MYCBP2/LAMTOR1/GNA13	23
GO:0001540	amyloid-beta binding	12/922	84/18367	0.000959195280265564	0.0116435649298903	ITGB2/CST3/CD74/CD36/LILRB2/TLR2/SORL1/ITGAM/PFDN5/TLR4/PICALM/PRNP	12
GO:0003823	antigen binding	19/922	171/18367	0.000982102532724237	0.0116530971240897	FCN1/HLA-B/HLA-C/HLA-A/HLA-DRA/CD48/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DQB1/ITGA4/HLA-F/TGFB1/LILRA2/HLA-DQA1/TAP1/TAPBP/SIRPA	19
GO:0060090	molecular adaptor activity	33/922	369/18367	0.000986698667258587	0.0116530971240897	AP1S2/LRRK2/KLF4/SCIMP/DOK2/IQGAP1/TRIM22/STX11/STX10/PAG1/SH2B3/LAMTOR4/AKAP13/ARPC4/ADAP2/GRB2/ITSN2/STAT3/GNB4/SDCBP/GNB2/SUN2/BICD2/GNB1/LAMTOR1/MYH9/ABI1/NUP62/HERPUD1/RB1CC1/STX7/STX12/CIB1	33
GO:0030674	protein-macromolecule adaptor activity	28/922	296/18367	0.000999979730328062	0.0116530971240897	AP1S2/LRRK2/KLF4/DOK2/IQGAP1/TRIM22/STX11/STX10/PAG1/SH2B3/AKAP13/ARPC4/ADAP2/GRB2/STAT3/GNB4/SDCBP/GNB2/SUN2/BICD2/GNB1/MYH9/ABI1/NUP62/HERPUD1/STX7/STX12/CIB1	28
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/922	10/18367	0.00103851270665801	0.0119428961265671	CYBB/CYBA/NCF1/NCF2	4
GO:0019956	chemokine binding	7/922	33/18367	0.00106481023046409	0.012086287550982	ZFP36/PLP2/ITGA4/CX3CR1/CCR1/CCR2/CXCR4	7
GO:0019210	kinase inhibitor activity	11/922	74/18367	0.00110551910972711	0.0123874833577114	GMFG/SOCS3/TRIB1/CHP1/PRKAG2/TAOK3/CDKN1A/PRKAR1A/YWHAB/WNK1/CIB1	11
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	5/922	17/18367	0.00117634664582481	0.0129345237664177	PYCARD/CASP1/CTSH/APAF1/CARD8	5
GO:0016504	peptidase activator activity	8/922	43/18367	0.00118393810218926	0.0129345237664177	PYCARD/CASP1/CTSH/APAF1/PSME2/PSME1/CARD8/TANK	8
GO:0008047	enzyme activator activity	14/922	110/18367	0.00120773853099523	0.0129522486586935	NCF1/GMFG/NCF2/CCL3/PSAP/NCF4/FYN/BTK/CALM2/DTX3L/ALOX5AP/CFLAR/DBNL/CTSA	14
GO:0002020	protease binding	16/922	135/18367	0.00121519953090717	0.0129522486586935	SERPINA1/CST3/PYCARD/CARD16/CSTA/TIMP1/SELL/TNFAIP3/PSAP/TNF/MBP/TIMP2/CFLAR/CSTB/PTEN/PRNP	16
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	38/922	450/18367	0.00124333866554407	0.0130925059480183	FOS/JUNB/KLF6/IRF1/FOSB/SPI1/EGR1/KLF4/CEBPD/MAFB/NR4A1/MEF2C/CEBPB/NR4A2/BACH1/TFEC/PLSCR1/STAT6/FLI1/HHEX/JUN/ELK3/REL/MEF2A/JUND/ELF1/LITAF/STAT3/FOSL2/KLF10/HIF1A/IRF2/CREBRF/ATF3/SP1/NR3C1/NFKB1/CREB1	38
GO:0004869	cysteine-type endopeptidase inhibitor activity	9/922	56/18367	0.00175936900909477	0.018305815642248	CST3/CARD16/CSTA/NAIP/BIRC3/RPS6KA3/CSTB/CAST/BIRC2	9
GO:0004709	MAP kinase kinase kinase activity	6/922	27/18367	0.00187918484327492	0.0193174420531155	LRRK2/MAP3K1/MAP3K3/MAP3K2/MAP3K11/MAP3K8	6
GO:0005200	structural constituent of cytoskeleton	13/922	103/18367	0.00192290327073346	0.0193174420531155	VIM/MSN/HLA-DRB1/ACTB/TUBA1A/ACTR2/ARPC1B/ARPC3/ACTR3/ARPC4/TLN1/ARPC5/PLEC	13
GO:0008238	exopeptidase activity	13/922	103/18367	0.00192290327073346	0.0193174420531155	LAP3/LTA4H/TPP1/CTSH/CPVL/CTSZ/SCPEP1/NUDT16/AGTPBP1/RNPEPL1/PRCP/LNPEP/CTSA	13
GO:0051861	glycolipid binding	6/922	28/18367	0.0022914923512601	0.0227586853977424	LYN/SELL/PSAP/CLEC4E/PPT1/TPP1	6
GO:0016505	peptidase activator activity involved in apoptotic process	5/922	20/18367	0.00260000614926094	0.0255326446567872	PYCARD/CASP1/CTSH/APAF1/CARD8	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	6/922	29/18367	0.00276836094901097	0.0267254672861149	DPYD/BLVRB/TBXAS1/BLVRA/DECR1/LBR	6
GO:0044325	transmembrane transporter binding	15/922	133/18367	0.00278262874489297	0.0267254672861149	TSPO/PYCARD/LRRK2/LYN/FLNA/SLC8A1/KCNE3/FYN/FKBP1A/CALM2/DIAPH1/PRNP/GRINA/HERPUD1/CIB1	15
GO:0043539	protein serine/threonine kinase activator activity	8/922	49/18367	0.00282452509474945	0.0268329884001198	DAZAP2/IQGAP1/CALM2/STK4/CCNY/CAB39/TAOK1/DDX3X	8
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	7/922	39/18367	0.00295131289237225	0.0277359942788532	IQGAP1/MYO1G/DAPP1/NRGN/BTK/ARAP1/ADAP2	7
GO:0042379	chemokine receptor binding	10/922	72/18367	0.00307141037201197	0.0285575815440262	CCL3L3/CCL3/STAT1/CXCL8/CX3CR1/CCR2/CCL4/JAK1/CKLF/STAT3	10
GO:0008157	protein phosphatase 1 binding	6/922	31/18367	0.00393989949876909	0.0362470753886756	LILRB2/LILRB1/C20orf27/PHACTR1/PPP1R15A/SHOC2	6
GO:0061135	endopeptidase regulator activity	19/922	194/18367	0.00418033813653183	0.0380584951180086	SERPINA1/CST3/CARD16/CSTA/TIMP1/BST2/NAIP/BIRC3/PSME2/SERPINB1/TIMP2/PSME1/RPS6KA3/CSTB/ROCK1/CAST/CARD8/PRNP/BIRC2	19
GO:0071889	14-3-3 protein binding	6/922	32/18367	0.00464685073772465	0.0418695623172303	ZFP36/ARRB2/HLA-F/ZFP36L1/IRS2/PPP1R12A	6
GO:0004725	protein tyrosine phosphatase activity	12/922	102/18367	0.00504642991284171	0.0450059157533026	DUSP1/PTPRC/DUSP6/PTPN6/PTPRE/PTP4A2/PTPN18/PTEN/SSH2/DUSP23/DUSP22/PTPN2	12
GO:0004180	carboxypeptidase activity	7/922	43/18367	0.00519784612708619	0.0458880557078114	LAP3/CPVL/CTSZ/SCPEP1/AGTPBP1/PRCP/CTSA	7
GO:0031072	heat shock protein binding	14/922	129/18367	0.00534869048041741	0.0467475547988481	ITGB2/ZFP36/GBP1/ITGAM/FKBP5/APAF1/SPN/HSPA1A/AHR/HIF1A/NR3C1/ARHGDIA/NUP62/CREB1	14
GO:0001530	lipopolysaccharide binding	6/922	33/18367	0.00544285973933809	0.0470995981404108	CD14/LY96/TLR2/TLR4/PTAFR/NINJ1	6
GO:0046332	SMAD binding	10/922	79/18367	0.00602886821049677	0.0512138264217515	FOS/FLNA/USP15/JUN/FKBP1A/MEF2A/SKIL/DDX5/ZBTB7A/TGFBR2	10
GO:0019957	C-C chemokine binding	5/922	24/18367	0.00603549670645355	0.0512138264217515	ZFP36/CX3CR1/CCR1/CCR2/CXCR4	5
GO:1901981	phosphatidylinositol phosphate binding	17/922	173/18367	0.00631023719377774	0.0527241861052613	IQGAP1/MYO1G/DAPP1/CAPG/NRGN/FGD2/NCF4/BTK/OSBPL8/ARAP1/ADAP2/PICALM/TWF2/SDCBP/PFN1/FLII/SNX18	17
GO:0043548	phosphatidylinositol 3-kinase binding	6/922	34/18367	0.00633414135131858	0.0527241861052613	CORO1A/HCST/JAK2/PIK3AP1/FYN/IRS2	6
GO:0008022	protein C-terminus binding	18/922	189/18367	0.00694333420712313	0.0567036507809294	CORO1A/NCF2/PABPC1/TNFAIP3/JAK2/CSK/PTK2B/SCLT1/YWHAB/SDCBP/NIPBL/PIAS1/DBNL/DYNLT1/FOXN3/SP1/EP300/CIB1	18
GO:0005092	GDP-dissociation inhibitor activity	4/922	16/18367	0.00707173676787335	0.0567036507809294	ARHGDIB/CCDC88A/GDI2/ARHGDIA	4
GO:0050135	NAD(P)+ nucleosidase activity	4/922	16/18367	0.00707173676787335	0.0567036507809294	TLR2/BST1/TLR4/TLR1	4
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	4/922	16/18367	0.00707173676787335	0.0567036507809294	TLR2/BST1/TLR4/TLR1	4
GO:0106310	protein serine kinase activity	29/922	360/18367	0.00842897132209509	0.066592489641569	LRRK2/STK17B/PRKCB/MAP3K1/MAP3K3/MAPKAPK3/STK10/PKN1/STK4/PAK1/TAOK3/SGK1/RPS6KA3/PAK2/PRKACA/MAP3K2/ROCK1/STK38/HIPK3/MAPK1/BMP2K/MAP3K11/ATM/MAP3K8/CLK1/TAOK1/HIPK1/WNK1/SMG1	29
GO:0004713	protein tyrosine kinase activity	14/922	136/18367	0.00845742695518573	0.066592489641569	LYN/FGR/HCK/JAK2/SYK/CSF1R/CSK/FYN/BTK/PTK2B/JAK1/HIPK3/CLK1/HIPK1	14
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	7/922	47/18367	0.00853359134994934	0.066592489641569	DUSP1/DUSP6/PTP4A2/PTEN/SSH2/DUSP23/DUSP22	7
GO:0004697	protein kinase C activity	4/922	17/18367	0.00888570295927292	0.0669491757448666	CCL3/PRKCB/PKN1/SMG1	4
GO:0042625	ATPase-coupled ion transmembrane transporter activity	4/922	17/18367	0.00888570295927292	0.0669491757448666	ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	4
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4/922	17/18367	0.00888570295927292	0.0669491757448666	ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	4
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4/922	17/18367	0.00888570295927292	0.0669491757448666	ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	4
GO:0048020	CCR chemokine receptor binding	7/922	48/18367	0.00956884748485402	0.0714098906513672	CCL3L3/CCL3/STAT1/CCR2/CCL4/JAK1/STAT3	7
GO:0043531	ADP binding	6/922	37/18367	0.00964115228473836	0.0714098906513672	TAP1/APAF1/PRKAG2/PGK1/MYO9B/MYH9	6
GO:0030246	carbohydrate binding	23/922	271/18367	0.00993230677565409	0.0729482027052241	VCAN/FCN1/LGALS2/SLC2A3/HLA-DRA/LGALS1/CLEC12A/CLEC7A/SELL/CD302/HLA-DRB1/CLEC4E/ASGR1/GPCPD1/LGALS9/CD93/CLEC4A/CLEC2B/CD33/FBP1/G6PD/PYGL/TALDO1	23
GO:0106306	protein serine phosphatase activity	9/922	73/18367	0.010594290984192	0.0765240522329242	DUSP1/DUSP6/CPPED1/PTEN/SSH2/DUSP23/PPP3CA/DUSP22/CTDSP1	9
GO:0106307	protein threonine phosphatase activity	9/922	73/18367	0.010594290984192	0.0765240522329242	DUSP1/DUSP6/CPPED1/PTEN/SSH2/DUSP23/PPP3CA/DUSP22/CTDSP1	9
GO:0032813	tumor necrosis factor receptor superfamily binding	7/922	49/18367	0.0106929012165381	0.0766032431414289	TNFSF13B/TNFSF10/STAT1/BID/TNF/MYD88/CFLAR	7
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	3/922	10/18367	0.0116022001984795	0.0775184375031103	PTPN18/DUSP22/PTPN2	3
GO:0005031	tumor necrosis factor-activated receptor activity	3/922	10/18367	0.0116022001984795	0.0775184375031103	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0005522	profilin binding	3/922	10/18367	0.0116022001984795	0.0775184375031103	VASP/WIPF1/RHOQ	3
GO:0008190	eukaryotic initiation factor 4E binding	3/922	10/18367	0.0116022001984795	0.0775184375031103	HHEX/EIF4EBP1/DDX3X	3
GO:0016176	superoxide-generating NADPH oxidase activator activity	3/922	10/18367	0.0116022001984795	0.0775184375031103	NCF1/NCF2/NCF4	3
GO:0034713	type I transforming growth factor beta receptor binding	3/922	10/18367	0.0116022001984795	0.0775184375031103	TGFB1/FKBP1A/TGFBR2	3
GO:0043208	glycosphingolipid binding	3/922	10/18367	0.0116022001984795	0.0775184375031103	LYN/SELL/PSAP	3
GO:0071723	lipopeptide binding	3/922	10/18367	0.0116022001984795	0.0775184375031103	CD14/TLR2/TLR1	3
GO:0003785	actin monomer binding	5/922	28/18367	0.0118283442750912	0.0775184375031103	TMSB4X/CORO1A/TMSB10/TWF2/PFN1	5
GO:0050681	androgen receptor binding	5/922	28/18367	0.0118283442750912	0.0775184375031103	PRKCB/PKN1/DDX5/ZBTB7A/EP300	5
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	7/922	50/18367	0.011909817666151	0.0775184375031103	TLR2/PIK3AP1/BST1/TLR8/MYD88/TLR4/TLR1	7
GO:0030159	signaling receptor complex adaptor activity	7/922	50/18367	0.011909817666151	0.0775184375031103	LRRK2/DOK2/SH2B3/GNB4/GNB2/GNB1/NUP62	7
GO:1990841	promoter-specific chromatin binding	8/922	62/18367	0.0119736716967047	0.0775184375031103	EGR1/KLF4/STAT1/USP3/DDX5/NIPBL/HNRNPU/TAF10	8
GO:0032452	histone demethylase activity	5/922	29/18367	0.0137158408013579	0.0862420493553008	KDM1B/JMJD1C/KDM6B/KDM7A/KDM5A	5
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	5/922	29/18367	0.0137158408013579	0.0862420493553008	NCF1/PLEK/MYO1G/DAPP1/ADAP2	5
GO:0051059	NF-kappaB binding	5/922	29/18367	0.0137158408013579	0.0862420493553008	NFKBIA/MTDH/NOTCH2/COMMD6/EP300	5
GO:0140457	protein demethylase activity	5/922	29/18367	0.0137158408013579	0.0862420493553008	KDM1B/JMJD1C/KDM6B/KDM7A/KDM5A	5
GO:0001664	G protein-coupled receptor binding	24/922	295/18367	0.0139253989079343	0.0869342760395329	FCN1/CCL3L3/FPR1/CCL3/FLNA/GNAI2/STAT1/ARRB2/CXCL8/JAK2/CX3CR1/CCR2/FYN/CCL4/JAK1/HSPA1A/ARAP1/CKLF/STAT3/GNAQ/SDCBP/GNAI3/PRNP/GNA13	24
GO:0004721	phosphoprotein phosphatase activity	16/922	174/18367	0.0143835612228032	0.0891576773668791	DUSP1/PTPRC/DUSP6/LRRK2/PTPN6/PTPRE/PTP4A2/PTPN18/CPPED1/PTEN/SSH2/DUSP23/PPP3CA/DUSP22/PTPN2/CTDSP1	16
GO:0005536	glucose binding	3/922	11/18367	0.0153652657010612	0.0939107847743184	SLC2A3/G6PD/PYGL	3
GO:0140036	ubiquitin-dependent protein binding	3/922	11/18367	0.0153652657010612	0.0939107847743184	LAPTM5/USP15/ANKRD13D	3
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	4/922	20/18367	0.0160544158833934	0.0967693757385227	ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	4
GO:0031683	G-protein beta/gamma-subunit complex binding	4/922	20/18367	0.0160544158833934	0.0967693757385227	GNAI2/GNAQ/GNAI3/GNA13	4
GO:0001046	core promoter sequence-specific DNA binding	6/922	42/18367	0.0176165237354445	0.105457820169715	FOS/STAT1/CEBPB/KLF10/DRAP1/NR3C1	6
GO:0035091	phosphatidylinositol binding	22/922	271/18367	0.0183910317214268	0.109345317853925	NCF1/SNX10/IQGAP1/MYO1G/DAPP1/CCDC88A/CAPG/NRGN/FGD2/NCF4/BTK/OSBPL8/ARAP1/ADAP2/TLN1/PICALM/TWF2/SDCBP/PFN1/FLII/SNX2/SNX18	22
GO:0140677	molecular function activator activity	14/922	150/18367	0.0188240241826843	0.111163494159906	NCF1/GMFG/NCF2/CCL3/PSAP/NCF4/FYN/BTK/CALM2/DTX3L/ALOX5AP/CFLAR/DBNL/CTSA	14
GO:0001848	complement binding	4/922	21/18367	0.0190617600205171	0.111811934616993	ITGB2/C5AR1/CD93/ITGAM	4
GO:0004866	endopeptidase inhibitor activity	16/922	180/18367	0.019253257829973	0.112182315622642	SERPINA1/CST3/CARD16/CSTA/TIMP1/BST2/NAIP/BIRC3/SERPINB1/TIMP2/RPS6KA3/CSTB/ROCK1/CAST/PRNP/BIRC2	16
GO:0005080	protein kinase C binding	7/922	55/18367	0.0195243907910427	0.11300872550577	PLEK/FLNA/MARCKS/PRKCB/CCDC88A/PKN1/TWF2	7
GO:0001223	transcription coactivator binding	5/922	32/18367	0.0205626904809991	0.118235470265745	AHR/HIF1A/CREBBP/EP300/CREB1	5
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	9/922	82/18367	0.0215212672613627	0.122938480957066	MYO1G/CAPG/ADAP2/PICALM/TWF2/SDCBP/PFN1/FLII/SNX18	9
GO:0051879	Hsp90 protein binding	6/922	44/18367	0.02179526580319	0.123695209818104	GBP1/AHR/HIF1A/NR3C1/ARHGDIA/NUP62	6
GO:0004714	transmembrane receptor protein tyrosine kinase activity	12/922	124/18367	0.0220217892552507	0.124174476187672	LYN/FGR/HCK/JAK2/SYK/CSF1R/CSK/FYN/BTK/PTK2B/JAK1/CLK1	12
GO:0004602	glutathione peroxidase activity	4/922	22/18367	0.0223947659014772	0.124668951578924	GPX1/MGST1/ALOX5AP/GSTK1	4
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/922	22/18367	0.0223947659014772	0.124668951578924	NAIP/BIRC3/RPS6KA3/BIRC2	4
GO:0005154	epidermal growth factor receptor binding	5/922	33/18367	0.0232626602562958	0.127871478389953	PLSCR1/HBEGF/CCDC88A/GRB2/SNX2	5
GO:0031369	translation initiation factor binding	5/922	33/18367	0.0232626602562958	0.127871478389953	HHEX/GCH1/EIF4EBP1/CELF1/DDX3X	5
GO:0004857	enzyme inhibitor activity	8/922	70/18367	0.0236122179572903	0.128981740591698	TXNIP/LRRK2/OAZ1/PARP9/DTX3L/PPP1R12A/TMBIM6/RNH1	8
GO:0048156	tau protein binding	6/922	45/18367	0.0241156171480009	0.130912734917987	ACTB/FYN/PICALM/ROCK1/TAOK1/EP300	6
GO:0005035	death receptor activity	3/922	13/18367	0.0247146467522516	0.130912734917987	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0034236	protein kinase A catalytic subunit binding	3/922	13/18367	0.0247146467522516	0.130912734917987	CSK/PRKAR1A/PJA2	3
GO:0061133	endopeptidase activator activity	3/922	13/18367	0.0247146467522516	0.130912734917987	PSME2/PSME1/CARD8	3
GO:0140035	ubiquitination-like modification-dependent protein binding	3/922	13/18367	0.0247146467522516	0.130912734917987	LAPTM5/USP15/ANKRD13D	3
GO:0004722	protein serine/threonine phosphatase activity	10/922	98/18367	0.0251750590737778	0.132548202593264	DUSP1/DUSP6/LRRK2/CPPED1/PTEN/SSH2/DUSP23/PPP3CA/DUSP22/CTDSP1	10
GO:0005158	insulin receptor binding	4/922	23/18367	0.026060914591712	0.134603045531607	CCDC88A/IRS2/PHIP/SNX2	4
GO:0009931	calcium-dependent protein serine/threonine kinase activity	4/922	23/18367	0.026060914591712	0.134603045531607	CCL3/PRKCB/MAPKAPK3/PKN1	4
GO:0016493	C-C chemokine receptor activity	4/922	23/18367	0.026060914591712	0.134603045531607	CX3CR1/CCR1/CCR2/CXCR4	4
GO:0030291	protein serine/threonine kinase inhibitor activity	5/922	34/18367	0.0261813704123263	0.134603045531607	PRKAG2/CDKN1A/PRKAR1A/WNK1/CIB1	5
GO:0030414	peptidase inhibitor activity	16/922	187/18367	0.0264234335581138	0.135053104852582	SERPINA1/CST3/CARD16/CSTA/TIMP1/BST2/NAIP/BIRC3/SERPINB1/TIMP2/RPS6KA3/CSTB/ROCK1/CAST/PRNP/BIRC2	16
GO:0019199	transmembrane receptor protein kinase activity	13/922	143/18367	0.0278699488987768	0.141618228706575	LYN/FGR/HCK/JAK2/SYK/CSF1R/CSK/FYN/BTK/PTK2B/JAK1/TGFBR2/CLK1	13
GO:0001965	G-protein alpha-subunit binding	4/922	24/18367	0.0300659981687636	0.148804875897362	RGS2/RGS19/CCDC88A/RGS10	4
GO:0010857	calcium-dependent protein kinase activity	4/922	24/18367	0.0300659981687636	0.148804875897362	CCL3/PRKCB/MAPKAPK3/PKN1	4
GO:0043274	phospholipase binding	4/922	24/18367	0.0300659981687636	0.148804875897362	WAS/SYK/FYN/BTK	4
GO:0004298	threonine-type endopeptidase activity	3/922	14/18367	0.0303057985237191	0.148804875897362	PSMB9/PSMB8/PSMB10	3
GO:0036041	long-chain fatty acid binding	3/922	14/18367	0.0303057985237191	0.148804875897362	S100A9/S100A8/ALOX5AP	3
GO:0044548	S100 protein binding	3/922	14/18367	0.0303057985237191	0.148804875897362	S100A6/IQGAP1/AHNAK	3
GO:0140030	modification-dependent protein binding	14/922	160/18367	0.0307376567629429	0.150082190004537	LAPTM5/LYN/TNFAIP3/USP15/PTPN6/ANKRD13D/KMT2E/CHD1/MSL3/KDM7A/PHIP/KMT2A/MORC3/KDM5A	14
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	5/922	36/18367	0.032694201057044	0.15874850957698	APOBEC3A/CDA/GCH1/MTHFD2/ADAR	5
GO:0005160	transforming growth factor beta receptor binding	4/922	25/18367	0.0344141625182702	0.165263615609715	USP15/TGFB1/FKBP1A/TGFBR2	4
GO:0030247	polysaccharide binding	4/922	25/18367	0.0344141625182702	0.165263615609715	HLA-DRA/CLEC7A/HLA-DRB1/GPCPD1	4
GO:0001618	virus receptor activity	8/922	76/18367	0.0363965727848538	0.171520989707833	CD4/CD86/PLSCR1/CXCR4/SELPLG/TNFRSF14/HSPA1A/ITGA5	8
GO:0001846	opsonin binding	3/922	15/18367	0.0365021785877082	0.171520989707833	ITGB2/CD93/ITGAM	3
GO:0005161	platelet-derived growth factor receptor binding	3/922	15/18367	0.0365021785877082	0.171520989707833	LYN/ITGA5/PTEN	3
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	3/922	15/18367	0.0365021785877082	0.171520989707833	PYCARD/CASP1/CFLAR	3
GO:0140272	exogenous protein binding	8/922	77/18367	0.0389053738562056	0.18084845516853	CD4/CD86/PLSCR1/CXCR4/SELPLG/TNFRSF14/HSPA1A/ITGA5	8
GO:0001637	G protein-coupled chemoattractant receptor activity	4/922	26/18367	0.0391079611291214	0.18084845516853	CX3CR1/CCR1/CCR2/CXCR4	4
GO:0004950	chemokine receptor activity	4/922	26/18367	0.0391079611291214	0.18084845516853	CX3CR1/CCR1/CCR2/CXCR4	4
GO:0051018	protein kinase A binding	6/922	51/18367	0.0415088017298541	0.190940487957329	LRRK2/CSK/AKAP13/PRKACA/PRKAR1A/PJA2	6
GO:0004698	calcium-dependent protein kinase C activity	3/922	16/18367	0.04329381900767	0.191105039458099	CCL3/PRKCB/PKN1	3
GO:0008191	metalloendopeptidase inhibitor activity	3/922	16/18367	0.04329381900767	0.191105039458099	TIMP1/BST2/TIMP2	3
GO:0016004	phospholipase activator activity	3/922	16/18367	0.04329381900767	0.191105039458099	CCL3/FYN/BTK	3
GO:0016208	AMP binding	3/922	16/18367	0.04329381900767	0.191105039458099	FBP1/PRKAG2/PYGL	3
GO:0035173	histone kinase activity	3/922	16/18367	0.04329381900767	0.191105039458099	JAK2/PRKCB/PKN1	3
GO:0035497	cAMP response element binding	3/922	16/18367	0.04329381900767	0.191105039458099	JUN/CREB5/CREB1	3
GO:0050700	CARD domain binding	3/922	16/18367	0.04329381900767	0.191105039458099	CARD16/CASP1/CARD8	3
GO:0070492	oligosaccharide binding	3/922	16/18367	0.04329381900767	0.191105039458099	LGALS1/SELL/LGALS9	3
GO:0043425	bHLH transcription factor binding	4/922	27/18367	0.0441484178467115	0.191268808619043	LMO2/SP1/CREBBP/USF2	4
GO:0070006	metalloaminopeptidase activity	4/922	27/18367	0.0441484178467115	0.191268808619043	LAP3/LTA4H/RNPEPL1/LNPEP	4
GO:0004402	histone acetyltransferase activity	5/922	39/18367	0.0442062921522274	0.191268808619043	MSL3/TAF10/CREBBP/EP300/EPC1	5
GO:0032451	demethylase activity	5/922	39/18367	0.0442062921522274	0.191268808619043	KDM1B/JMJD1C/KDM6B/KDM7A/KDM5A	5
GO:0004879	nuclear receptor activity	6/922	52/18367	0.0450136670666811	0.192852671648428	NR4A1/NR4A2/AHR/STAT3/RXRA/NR3C1	6
GO:0098531	ligand-activated transcription factor activity	6/922	52/18367	0.0450136670666811	0.192852671648428	NR4A1/NR4A2/AHR/STAT3/RXRA/NR3C1	6
GO:0005543	phospholipid binding	32/922	466/18367	0.0455330689896634	0.194126352668126	NCF1/SNX10/PSAP/IQGAP1/PPT1/TPP1/MYO1G/DAPP1/CCDC88A/CAPG/ARHGAP26/NRGN/CD300LF/FGD2/PTAFR/NCF4/CD300A/BTK/PREX1/OSBPL8/ARAP1/ADAP2/TLN1/PICALM/TWF2/SDCBP/BIN2/PFN1/FLII/SNX2/NUP62/SNX18	32
GO:0004177	aminopeptidase activity	5/922	40/18367	0.0485181762955621	0.205848961564667	LAP3/LTA4H/CTSH/RNPEPL1/LNPEP	5
GO:0046875	ephrin receptor binding	4/922	28/18367	0.0495350967753149	0.205967192576993	LYN/FYN/GRB2/SDCBP	4
GO:0000149	SNARE binding	10/922	110/18367	0.0497229041623859	0.205967192576993	STXBP2/LRRK2/TNFAIP2/STX11/STX10/PICALM/PTPN2/STX7/STX12/BLOC1S6	10
GO:0097110	scaffold protein binding	7/922	67/18367	0.0502376522826181	0.205967192576993	VIM/LYN/PSAP/SYK/TREM1/FYN/CD163	7
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/922	17/18367	0.0506669867323266	0.205967192576993	PTPRC/PTPN6/PTPRE	3
GO:0005149	interleukin-1 receptor binding	3/922	17/18367	0.0506669867323266	0.205967192576993	IL1B/IL1RN/MYD88	3
GO:0008484	sulfuric ester hydrolase activity	3/922	17/18367	0.0506669867323266	0.205967192576993	SULF2/GNS/IDS	3
GO:0017081	chloride channel regulator activity	3/922	17/18367	0.0506669867323266	0.205967192576993	SGK1/WNK1/STX7	3
GO:0019198	transmembrane receptor protein phosphatase activity	3/922	17/18367	0.0506669867323266	0.205967192576993	PTPRC/PTPN6/PTPRE	3
GO:0070064	proline-rich region binding	3/922	17/18367	0.0506669867323266	0.205967192576993	CSK/CYLD/PFN1	3
GO:0061733	peptide-lysine-N-acetyltransferase activity	5/922	41/18367	0.0530694396371683	0.214734677050394	MSL3/TAF10/CREBBP/EP300/EPC1	5
GO:0008080	N-acetyltransferase activity	7/922	68/18367	0.0536887936309759	0.21623965729711	SAT1/SAT2/MSL3/TAF10/CREBBP/EP300/EPC1	7
GO:0042826	histone deacetylase binding	11/922	127/18367	0.0546590252229836	0.219137559838934	SPI1/KLF4/MEF2C/CEBPB/HSPA1A/MEF2A/PKN1/YWHAB/HIF1A/NIPBL/SP1	11
GO:0046625	sphingolipid binding	4/922	29/18367	0.055266177731148	0.220559996972709	LYN/SELL/PSAP/CD300LF	4
GO:0008234	cysteine-type peptidase activity	15/922	190/18367	0.0557808294100187	0.221602022292529	CTSS/PYCARD/CASP1/TNFAIP3/USP15/CTSH/CTSZ/USP3/CTSB/CAPN2/CAPNS1/OTUD1/CFLAR/CYLD/TANK	15
GO:0030228	lipoprotein particle receptor activity	3/922	18/18367	0.0586047475764476	0.230723195413582	CD36/SORL1/APOBR	3
GO:0060229	lipase activator activity	3/922	18/18367	0.0586047475764476	0.230723195413582	CCL3/FYN/BTK	3
GO:0048029	monosaccharide binding	7/922	71/18367	0.0649135267380394	0.25377463897322	SLC2A3/LGALS9/CLEC4A/FBP1/G6PD/PYGL/TALDO1	7
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	22/922	310/18367	0.0650406397368436	0.25377463897322	ZEB2/SPI1/IFI16/CEBPB/LRRFIP1/BACH1/TFEC/MXD1/HHEX/BCL6/IRF8/JUN/ELK3/SKIL/ATF3/ZBTB7A/ZNF217/MAX/ETS2/NR3C1/NFKB1/SP3	22
GO:0042393	histone binding	18/922	244/18367	0.066530864956954	0.258053538082106	STAT1/USP15/JAK2/PRKCB/USP3/PARP9/KDM1B/PKN1/DTX3L/KMT2E/CHD1/MSL3/KDM7A/KMT2C/PHIP/KMT2A/MORC3/KDM5A	18
GO:0016209	antioxidant activity	8/922	86/18367	0.0667278027534965	0.258053538082106	S100A9/SOD2/PTGS2/GPX1/MGST1/GLRX/ALOX5AP/GSTK1	8
GO:0000146	microfilament motor activity	4/922	31/18367	0.0677478240336194	0.259699992128875	MYO1F/MYO1G/MYO9B/MYH9	4
GO:0005164	tumor necrosis factor receptor binding	4/922	31/18367	0.0677478240336194	0.259699992128875	TNFSF13B/TNFSF10/STAT1/TNF	4
GO:0004712	protein serine/threonine/tyrosine kinase activity	5/922	44/18367	0.0681592763713146	0.260136277504493	MAPKAPK3/SGK1/PRKACA/MAPK1/CLK1	5
GO:0001217	DNA-binding transcription repressor activity	22/922	313/18367	0.0705434908708005	0.268065265309042	ZEB2/SPI1/IFI16/CEBPB/LRRFIP1/BACH1/TFEC/MXD1/HHEX/BCL6/IRF8/JUN/ELK3/SKIL/ATF3/ZBTB7A/ZNF217/MAX/ETS2/NR3C1/NFKB1/SP3	22
GO:0033293	monocarboxylic acid binding	7/922	73/18367	0.0731281121977899	0.276683853077352	S100A9/S100A8/PSAP/ALOX5AP/RXRA/PYGL/ARHGDIA	7
GO:0042578	phosphoric ester hydrolase activity	25/922	366/18367	0.0738974872596849	0.277034039004665	DUSP1/PTPRC/SAMHD1/DUSP6/LRRK2/PTPN6/GPCPD1/PTPRE/CCR1/PTP4A2/PLCB2/INPP5D/FBP1/PTPN18/NUDT16/CPPED1/PTEN/GNB1/SSH2/HMOX1/DUSP23/PPP3CA/DUSP22/PTPN2/CTDSP1	25
GO:0031490	chromatin DNA binding	9/922	103/18367	0.0739847428176287	0.277034039004665	ACTB/BCL6/JMJD1C/STAT3/KDM6B/MBD2/HNRNPU/CREBBP/EP300	9
GO:0048306	calcium-dependent protein binding	8/922	88/18367	0.0742350444595331	0.277034039004665	S100A9/S100A4/S100A8/S100A12/S100A6/CALM2/CHP1/DDX5	8
GO:0001222	transcription corepressor binding	4/922	32/18367	0.0744885573982795	0.277034039004665	STAT1/CTBP2/ZBTB7A/FAM89B	4
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/922	20/18367	0.0760933091193132	0.2785566015742	FOS/STAT1/CEBPB	3
GO:0001091	RNA polymerase II general transcription initiation factor binding	3/922	20/18367	0.0760933091193132	0.2785566015742	AHR/DRAP1/HNRNPU	3
GO:0030506	ankyrin binding	3/922	20/18367	0.0760933091193132	0.2785566015742	PTPRC/SLC8A1/PLEC	3
GO:0004197	cysteine-type endopeptidase activity	10/922	119/18367	0.0761728006593064	0.2785566015742	CTSS/PYCARD/CASP1/USP15/CTSH/CTSZ/CTSB/CAPN2/CAPNS1/CFLAR	10
GO:0061980	regulatory RNA binding	5/922	46/18367	0.0794048833936354	0.288541688709144	NEAT1/YBX1/MBD2/DICER1/DDX21	5
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	6/922	60/18367	0.0795635548957707	0.288541688709144	DPYD/BLVRB/TBXAS1/BLVRA/DECR1/LBR	6
GO:1990782	protein tyrosine kinase binding	9/922	105/18367	0.0812847484311067	0.293565579044575	DOK2/DAZAP2/CD4/ITGAX/SH2B3/SIRPA/PTEN/DUSP22/PTPN2	9
GO:0005125	cytokine activity	17/922	235/18367	0.0838093789609448	0.29828734934181	IL1B/CCL3L3/TNFSF13B/NAMPT/CCL3/TIMP1/TNFSF10/CXCL8/SECTM1/IL1RN/GRN/TGFB1/TNF/CCL4/CMTM7/CMTM3/CKLF	17
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	3/922	21/18367	0.0855985673024458	0.29828734934181	LPGAT1/LPCAT2/MBOAT7	3
GO:0005123	death receptor binding	3/922	21/18367	0.0855985673024458	0.29828734934181	BID/MYD88/CFLAR	3
GO:0016407	acetyltransferase activity	8/922	91/18367	0.0864137619892792	0.29828734934181	SAT1/LPCAT2/SAT2/MSL3/TAF10/CREBBP/EP300/EPC1	8
GO:0004690	cyclic nucleotide-dependent protein kinase activity	2/922	10/18367	0.0866876278407548	0.29828734934181	AKAP13/PRKACA	2
GO:0005528	FK506 binding	2/922	10/18367	0.0866876278407548	0.29828734934181	FKBP5/FKBP1A	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/922	10/18367	0.0866876278407548	0.29828734934181	DUSP1/DUSP6	2
GO:0019869	chloride channel inhibitor activity	2/922	10/18367	0.0866876278407548	0.29828734934181	WNK1/STX7	2
GO:0045503	dynein light chain binding	2/922	10/18367	0.0866876278407548	0.29828734934181	GLUL/HOOK3	2
GO:0047844	deoxycytidine deaminase activity	2/922	10/18367	0.0866876278407548	0.29828734934181	APOBEC3A/CDA	2
GO:0051880	G-quadruplex DNA binding	2/922	10/18367	0.0866876278407548	0.29828734934181	CNBP/XRN1	2
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	2/922	10/18367	0.0866876278407548	0.29828734934181	CASP1/CFLAR	2
GO:0003714	transcription corepressor activity	14/922	187/18367	0.0884624150589688	0.30268491549436	BTG2/TRIM22/PFDN5/PARP9/HSPA1A/PARP14/RB1/CTBP2/PIAS1/DRAP1/SPEN/HNRNPU/CREBBP/IRF2BP2	14
GO:0019208	phosphatase regulator activity	9/922	107/18367	0.0890046032975408	0.30268491549436	ZEB2/PHACTR1/PPP1R15A/CALM2/BMP2K/BOD1L1/PPP1R15B/SHOC2/PPP1R12A	9
GO:1902936	phosphatidylinositol bisphosphate binding	9/922	107/18367	0.0890046032975408	0.30268491549436	MYO1G/CAPG/ADAP2/PICALM/TWF2/SDCBP/PFN1/FLII/SNX18	9
GO:0099106	ion channel regulator activity	11/922	139/18367	0.0906562413510672	0.306127967491028	FLNA/FXYD5/PRKCB/KCNE3/CALM2/CHP1/SGK1/SCLT1/GNB2/WNK1/STX7	11
GO:0051213	dioxygenase activity	8/922	92/18367	0.0907175555837257	0.306127967491028	PTGS2/ALOX5/JMJD1C/ALOX5AP/KDM6B/TET2/KDM7A/KDM5A	8
GO:0038024	cargo receptor activity	7/922	77/18367	0.0913121718424235	0.306663552877633	ITGB2/CD36/ASGR1/SORL1/ITGAM/APOBR/CD163	7
GO:0015026	coreceptor activity	5/922	48/18367	0.0915780175069361	0.306663552877633	ITGA4/LY96/CD4/CD86/CXCR4	5
GO:0030742	GTP-dependent protein binding	3/922	22/18367	0.0955781148920724	0.316421486422997	RAB32/GCH1/CDC42	3
GO:0033691	sialic acid binding	3/922	22/18367	0.0955781148920724	0.316421486422997	FCN1/CD33/ST8SIA4	3
GO:0050321	tau-protein kinase activity	3/922	22/18367	0.0955781148920724	0.316421486422997	FYN/ROCK1/TAOK1	3
GO:0008009	chemokine activity	5/922	49/18367	0.0980040907252265	0.318381365549995	CCL3L3/CCL3/CXCL8/CCL4/CKLF	5
GO:0016763	pentosyltransferase activity	5/922	49/18367	0.0980040907252265	0.318381365549995	TYMP/NAMPT/UPP1/PARP9/PARP14	5
GO:0034212	peptide N-acetyltransferase activity	5/922	49/18367	0.0980040907252265	0.318381365549995	MSL3/TAF10/CREBBP/EP300/EPC1	5
GO:0016791	phosphatase activity	19/922	275/18367	0.0995258312429009	0.318381365549995	DUSP1/PTPRC/DUSP6/LRRK2/PTPN6/PTPRE/PTP4A2/INPP5D/FBP1/PTPN18/NUDT16/CPPED1/PTEN/SSH2/DUSP23/PPP3CA/DUSP22/PTPN2/CTDSP1	19
GO:0005078	MAP-kinase scaffold activity	2/922	11/18367	0.102537041649576	0.318381365549995	IQGAP1/AKAP13	2
GO:0008199	ferric iron binding	2/922	11/18367	0.102537041649576	0.318381365549995	FTL/FTH1	2
GO:0008603	cAMP-dependent protein kinase regulator activity	2/922	11/18367	0.102537041649576	0.318381365549995	PRKAG2/PRKAR1A	2
GO:0010485	H4 histone acetyltransferase activity	2/922	11/18367	0.102537041649576	0.318381365549995	MSL3/EP300	2
GO:0031434	mitogen-activated protein kinase kinase binding	2/922	11/18367	0.102537041649576	0.318381365549995	TRIB1/MAP3K11	2
GO:0035197	siRNA binding	2/922	11/18367	0.102537041649576	0.318381365549995	MBD2/DICER1	2
GO:0043560	insulin receptor substrate binding	2/922	11/18367	0.102537041649576	0.318381365549995	JAK2/GRB2	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/922	11/18367	0.102537041649576	0.318381365549995	GLRX/PGK1	2
GO:0047676	arachidonate-CoA ligase activity	2/922	11/18367	0.102537041649576	0.318381365549995	ACSL1/ACSL4	2
GO:0051400	BH domain binding	2/922	11/18367	0.102537041649576	0.318381365549995	MCL1/BCL2A1	2
GO:0097493	structural molecule activity conferring elasticity	2/922	11/18367	0.102537041649576	0.318381365549995	EMILIN2/AHNAK	2
GO:0046982	protein heterodimerization activity	22/922	328/18367	0.102803077974624	0.318381365549995	CYBB/CYBA/MCL1/BCL2A1/IRAK3/NR4A1/MEF2C/CEBPB/NR4A2/GCA/TLR4/AHR/MEF2A/SDCBP/HIF1A/ATF3/DRAP1/MICU1/POLE4/SNX2/MAX/USF2	22
GO:0005484	SNAP receptor activity	4/922	36/18367	0.104621188571535	0.318381365549995	STX11/STX10/STX7/STX12	4
GO:0043394	proteoglycan binding	4/922	36/18367	0.104621188571535	0.318381365549995	CTSS/PTPRC/CTSB/SDCBP	4
GO:0061631	ubiquitin conjugating enzyme activity	4/922	36/18367	0.104621188571535	0.318381365549995	UBE2L6/UBE2D1/UBE2D3/UBE2R2	4
GO:0097718	disordered domain specific binding	4/922	36/18367	0.104621188571535	0.318381365549995	FYN/HSPA1A/CALM2/RB1	4
GO:0008143	poly(A) binding	3/922	23/18367	0.106005694937127	0.318381365549995	PABPC1/HNRNPU/DDX3X	3
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	3/922	23/18367	0.106005694937127	0.318381365549995	PTGS2/ALOX5/ALOX5AP	3
GO:0016849	phosphorus-oxygen lyase activity	3/922	23/18367	0.106005694937127	0.318381365549995	RNASET2/BST1/ADCY7	3
GO:0017025	TBP-class protein binding	3/922	23/18367	0.106005694937127	0.318381365549995	HHEX/AHR/DRAP1	3
GO:0042171	lysophosphatidic acid acyltransferase activity	3/922	23/18367	0.106005694937127	0.318381365549995	LPGAT1/LPCAT2/MBOAT7	3
GO:0070412	R-SMAD binding	3/922	23/18367	0.106005694937127	0.318381365549995	FOS/JUN/DDX5	3
GO:0071617	lysophospholipid acyltransferase activity	3/922	23/18367	0.106005694937127	0.318381365549995	LPGAT1/LPCAT2/MBOAT7	3
GO:0030145	manganese ion binding	6/922	65/18367	0.107003405151781	0.320277315420058	SOD2/LAP3/GLUL/NUDT16/PRKACA/MGAT1	6
GO:0140678	molecular function inhibitor activity	10/922	128/18367	0.109997537359656	0.328115520997744	TXNIP/LRRK2/OAZ1/PARP9/CALM2/DTX3L/PPP1R12A/TMBIM6/RNH1/WNK1	10
GO:0004601	peroxidase activity	5/922	51/18367	0.111514378075898	0.331508729382092	PTGS2/GPX1/MGST1/ALOX5AP/GSTK1	5
GO:0002039	p53 binding	6/922	66/18367	0.113010726113874	0.333750174328874	HIF1A/ZNF385A/MDM4/EEF2/CREBBP/EP300	6
GO:0016247	channel regulator activity	11/922	145/18367	0.113032095653715	0.333750174328874	FLNA/FXYD5/PRKCB/KCNE3/CALM2/CHP1/SGK1/SCLT1/GNB2/WNK1/STX7	11
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3/922	24/18367	0.116854223046893	0.337958744345731	PTGS2/ALOX5/ALOX5AP	3
GO:0043495	protein-membrane adaptor activity	3/922	24/18367	0.116854223046893	0.337958744345731	SUN2/MYH9/CIB1	3
GO:0070003	threonine-type peptidase activity	3/922	24/18367	0.116854223046893	0.337958744345731	PSMB9/PSMB8/PSMB10	3
GO:0004126	cytidine deaminase activity	2/922	12/18367	0.119097589540601	0.337958744345731	APOBEC3A/CDA	2
GO:0004875	complement receptor activity	2/922	12/18367	0.119097589540601	0.337958744345731	FPR1/C5AR1	2
GO:0005095	GTPase inhibitor activity	2/922	12/18367	0.119097589540601	0.337958744345731	IQGAP1/CDC42SE1	2
GO:0005527	macrolide binding	2/922	12/18367	0.119097589540601	0.337958744345731	FKBP5/FKBP1A	2
GO:0017154	semaphorin receptor activity	2/922	12/18367	0.119097589540601	0.337958744345731	PLXNC1/PLXNB2	2
GO:0034452	dynactin binding	2/922	12/18367	0.119097589540601	0.337958744345731	BICD2/HOOK3	2
GO:0035256	G protein-coupled glutamate receptor binding	2/922	12/18367	0.119097589540601	0.337958744345731	FYN/PRNP	2
GO:0043422	protein kinase B binding	2/922	12/18367	0.119097589540601	0.337958744345731	ARRB2/CCDC88A	2
GO:0061578	Lys63-specific deubiquitinase activity	2/922	12/18367	0.119097589540601	0.337958744345731	TNFAIP3/CYLD	2
GO:0050661	NADP binding	5/922	53/18367	0.125869283308696	0.356018620102914	DPYD/G6PD/PGD/DECR1/LBR	5
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/922	25/18367	0.128096049482614	0.361148216928402	ZFP36/ZFP36L2/ZFP36L1	3
GO:0005504	fatty acid binding	4/922	39/18367	0.130293669689305	0.364989318296323	S100A9/S100A8/ALOX5AP/ARHGDIA	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/922	39/18367	0.130293669689305	0.364989318296323	UBE2L6/UBE2D1/UBE2D3/UBE2R2	4
GO:0005518	collagen binding	6/922	69/18367	0.132022417997856	0.368650457923727	CTSS/CD44/TGFBI/CTSB/PAK1/CRTAP	6
GO:0015459	potassium channel regulator activity	5/922	54/18367	0.133349667229972	0.370995641415285	FLNA/KCNE3/CHP1/SGK1/WNK1	5
GO:0005516	calmodulin binding	14/922	201/18367	0.135317084452315	0.370995641415285	RGS2/MYO1F/MARCKS/IQGAP1/MYO1G/SLC8A1/NRGN/MBP/CNN2/MAPKAPK3/DDX5/MYO9B/MYH9/PPP3CA	14
GO:0008179	adenylate cyclase binding	2/922	13/18367	0.136258124593028	0.370995641415285	CAP1/CALM2	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/922	13/18367	0.136258124593028	0.370995641415285	GLRX/PGK1	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/922	13/18367	0.136258124593028	0.370995641415285	DUSP1/DUSP6	2
GO:0031404	chloride ion binding	2/922	13/18367	0.136258124593028	0.370995641415285	NUDT16/NQO2	2
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	2/922	13/18367	0.136258124593028	0.370995641415285	JMJD1C/KDM7A	2
GO:0072542	protein phosphatase activator activity	2/922	13/18367	0.136258124593028	0.370995641415285	PPP1R15A/CALM2	2
GO:0004364	glutathione transferase activity	3/922	26/18367	0.139703191441765	0.378020400371835	MGST1/ALOX5AP/GSTK1	3
GO:0008198	ferrous iron binding	3/922	26/18367	0.139703191441765	0.378020400371835	FTL/FTH1/TET2	3
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/922	55/18367	0.141023945578145	0.38041644578796	PTGS2/GPX1/MGST1/ALOX5AP/GSTK1	5
GO:0003712	transcription coregulator activity	30/922	489/18367	0.149452200876055	0.401911457125144	BTG2/MTDH/LMO2/PRKCB/TRIM22/PFDN5/PARP9/HSPA1A/JMJD1C/PARP14/TRIM38/PKN1/BTG1/MED13L/RB1/NCOA4/CTBP2/PIAS1/DRAP1/ARID1A/SPEN/HNRNPU/KDM7A/KMT2C/NMI/CREBBP/EP300/IRF2BP2/KDM5A/BIRC2	30
GO:0030507	spectrin binding	3/922	27/18367	0.151647538141147	0.403973943118326	PTPRC/GBP1/GNB1	3
GO:0051959	dynein light intermediate chain binding	3/922	27/18367	0.151647538141147	0.403973943118326	CCDC88A/BICD2/HOOK3	3
GO:0008235	metalloexopeptidase activity	6/922	72/18367	0.152445559173546	0.403973943118326	LAP3/LTA4H/NUDT16/AGTPBP1/RNPEPL1/LNPEP	6
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/922	14/18367	0.15391684560458	0.403973943118326	DOK2/SH2B3	2
GO:0005172	vascular endothelial growth factor receptor binding	2/922	14/18367	0.15391684560458	0.403973943118326	CCDC88A/ITGA5	2
GO:0017110	nucleoside-diphosphatase activity	2/922	14/18367	0.15391684560458	0.403973943118326	ENTPD1/NUDT16	2
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	2/922	14/18367	0.15391684560458	0.403973943118326	P2RY13/PTAFR	2
GO:0071837	HMG box domain binding	2/922	14/18367	0.15391684560458	0.403973943118326	JUN/SP1	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	5/922	57/18367	0.156928181263852	0.410644402468882	IFI30/SCO2/MSRB1/GLRX/PGK1	5
GO:0035064	methylated histone binding	6/922	73/18367	0.159548614126599	0.415016335555499	KMT2E/CHD1/MSL3/KDM7A/MORC3/KDM5A	6
GO:0140034	methylation-dependent protein binding	6/922	73/18367	0.159548614126599	0.415016335555499	KMT2E/CHD1/MSL3/KDM7A/MORC3/KDM5A	6
GO:0017022	myosin binding	6/922	74/18367	0.16679214374344	0.431290927904634	PYCARD/CORO1A/CXCR4/RHOA/RAB27A/RAB10	6
GO:0019905	syntaxin binding	6/922	74/18367	0.16679214374344	0.431290927904634	STXBP2/LRRK2/STX10/PTPN2/STX7/BLOC1S6	6
GO:0005246	calcium channel regulator activity	4/922	43/18367	0.168056776860121	0.433173140701557	PRKCB/CALM2/SGK1/GNB2	4
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/922	15/18367	0.171980640530252	0.433173140701557	ALDH2/ALDH1A1	2
GO:0004467	long-chain fatty acid-CoA ligase activity	2/922	15/18367	0.171980640530252	0.433173140701557	ACSL1/ACSL4	2
GO:0005041	low-density lipoprotein particle receptor activity	2/922	15/18367	0.171980640530252	0.433173140701557	CD36/SORL1	2
GO:0005545	1-phosphatidylinositol binding	2/922	15/18367	0.171980640530252	0.433173140701557	SNX10/PICALM	2
GO:0032794	GTPase activating protein binding	2/922	15/18367	0.171980640530252	0.433173140701557	FMNL1/GNAI3	2
GO:0048185	activin binding	2/922	15/18367	0.171980640530252	0.433173140701557	FKBP1A/TGFBR2	2
GO:0050998	nitric-oxide synthase binding	2/922	15/18367	0.171980640530252	0.433173140701557	CD74/ACTB	2
GO:1904680	peptide transmembrane transporter activity	2/922	15/18367	0.171980640530252	0.433173140701557	TAP1/TAPBP	2
GO:0036002	pre-mRNA binding	5/922	59/18367	0.17352738989948	0.435813042448693	CELF2/DDX5/HNRNPU/CELF1/EP300	5
GO:0070717	poly-purine tract binding	3/922	29/18367	0.176435821878958	0.441847874848737	PABPC1/HNRNPU/DDX3X	3
GO:0015631	tubulin binding	23/922	375/18367	0.187520242594577	0.466046354851868	S100A9/S100A8/RGS2/LRRK2/LYN/MX1/MX2/CCDC88A/FYN/DPYSL2/AGTPBP1/GABARAP/CCDC69/NIN/CHP1/PAK1/SUN2/CEP350/TAOK1/DDX3X/PRNP/HOOK3/ZNF207	23
GO:0016798	hydrolase activity, acting on glycosyl bonds	10/922	144/18367	0.187657551735844	0.466046354851868	LYZ/TLR2/PIK3AP1/BST1/TLR8/MYD88/TLR4/TLR1/CTBS/NAGA	10
GO:0047485	protein N-terminus binding	8/922	110/18367	0.187842014855927	0.466046354851868	GLRX/HSPA1A/CALM2/ALOX5AP/SDCBP/NIPBL/ATM/BIRC2	8
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/922	16/18367	0.190364472176335	0.466046354851868	ALDH2/ALDH1A1	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	2/922	16/18367	0.190364472176335	0.466046354851868	CAPN2/CAPNS1	2
GO:0005523	tropomyosin binding	2/922	16/18367	0.190364472176335	0.466046354851868	PYCARD/S100A6	2
GO:0070402	NADPH binding	2/922	16/18367	0.190364472176335	0.466046354851868	DECR1/LBR	2
GO:1990404	protein ADP-ribosylase activity	2/922	16/18367	0.190364472176335	0.466046354851868	PARP9/PARP14	2
GO:0016410	N-acyltransferase activity	7/922	94/18367	0.192874859568031	0.470873260509663	SAT1/SAT2/MSL3/TAF10/CREBBP/EP300/EPC1	7
GO:0140296	general transcription initiation factor binding	4/922	46/18367	0.198594424396411	0.483486147416333	HHEX/AHR/DRAP1/HNRNPU	4
GO:0016411	acylglycerol O-acyltransferase activity	3/922	31/18367	0.202239757629274	0.489633097418243	LPGAT1/LPCAT2/MBOAT7	3
GO:0043015	gamma-tubulin binding	3/922	31/18367	0.202239757629274	0.489633097418243	LYN/PAK1/DDX3X	3
GO:0003951	NAD+ kinase activity	2/922	17/18367	0.20899080356887	0.495328897151512	NADK/DGKZ	2
GO:0030169	low-density lipoprotein particle binding	2/922	17/18367	0.20899080356887	0.495328897151512	CD36/SORL1	2
GO:0031489	myosin V binding	2/922	17/18367	0.20899080356887	0.495328897151512	RAB27A/RAB10	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/922	17/18367	0.20899080356887	0.495328897151512	KMT2C/KMT2A	2
GO:0043024	ribosomal small subunit binding	2/922	17/18367	0.20899080356887	0.495328897151512	EIF1/DDX3X	2
GO:0050780	dopamine receptor binding	2/922	17/18367	0.20899080356887	0.495328897151512	ARRB2/GNA13	2
GO:0052745	inositol phosphate phosphatase activity	2/922	17/18367	0.20899080356887	0.495328897151512	INPP5D/PTEN	2
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/922	47/18367	0.209126273511336	0.495328897151512	ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	4
GO:0051721	protein phosphatase 2A binding	3/922	32/18367	0.21545539903248	0.508940591228075	STAT1/EIF4EBP1/BOD1L1	3
GO:0000287	magnesium ion binding	14/922	221/18367	0.22165739043241	0.52217940495398	LRRK2/IRAK3/TKT/PLSCR1/GLUL/NUDT16/STK4/RPS6KA3/PRKACA/STK38/NUDT3/MTHFD2/MAP3K8/WNK1	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	14/922	222/18367	0.226500346086801	0.527733466203481	SAT1/LPGAT1/LPCAT2/GLUL/SPTLC2/ELOVL5/SAT2/ZDHHC20/MBOAT7/MSL3/TAF10/CREBBP/EP300/EPC1	14
GO:0004708	MAP kinase kinase activity	2/922	18/18367	0.227789060567922	0.527733466203481	MAPKAPK3/MAPK1	2
GO:0008409	5'-3' exonuclease activity	2/922	18/18367	0.227789060567922	0.527733466203481	XRN2/XRN1	2
GO:0033549	MAP kinase phosphatase activity	2/922	18/18367	0.227789060567922	0.527733466203481	DUSP1/DUSP6	2
GO:0042834	peptidoglycan binding	2/922	18/18367	0.227789060567922	0.527733466203481	TLR2/NLRP3	2
GO:0098918	structural constituent of synapse	2/922	18/18367	0.227789060567922	0.527733466203481	ACTB/CTBP2	2
GO:0019239	deaminase activity	3/922	33/18367	0.22884551909739	0.527733466203481	APOBEC3A/CDA/ADAR	3
GO:0051427	hormone receptor binding	3/922	33/18367	0.22884551909739	0.527733466203481	JAK2/FYN/JAK1	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/922	50/18367	0.241595439082864	0.555669509890586	CCNL1/CCNI/CDKN1A/CCNY	4
GO:0035198	miRNA binding	3/922	34/18367	0.242385029773313	0.556022351763453	NEAT1/YBX1/DDX21	3
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	2/922	19/18367	0.246695129442511	0.564428123384173	BLVRB/MTHFD2	2
GO:0042887	amide transmembrane transporter activity	3/922	35/18367	0.256049629339256	0.584301242930835	TAP1/AQP9/TAPBP	3
GO:0004386	helicase activity	10/922	156/18367	0.258275828894449	0.587846548056636	SETX/DDX60L/DDX5/CHD1/CHD9/IFIH1/DICER1/DDX21/DDX3X/HELZ	10
GO:0020037	heme binding	9/922	139/18367	0.263961222608281	0.596860862369969	CYBB/CYBA/PTGS2/CYP1B1/JAK2/BACH1/TBXAS1/CYB5R4/HMOX1	9
GO:0019211	phosphatase activator activity	2/922	20/18367	0.265650887256199	0.596860862369969	PPP1R15A/CALM2	2
GO:0030296	protein tyrosine kinase activator activity	2/922	20/18367	0.265650887256199	0.596860862369969	PAK2/ABI1	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/922	20/18367	0.265650887256199	0.596860862369969	KLF4/SOCS3	2
GO:0097001	ceramide binding	2/922	20/18367	0.265650887256199	0.596860862369969	PSAP/CD300LF	2
GO:0015248	sterol transporter activity	3/922	36/18367	0.269815851227231	0.603487419556815	TSPO/NPC2/OSBPL8	3
GO:0031406	carboxylic acid binding	11/922	176/18367	0.27038129985608	0.603487419556815	FCN1/S100A9/S100A8/PSAP/CD33/GLUL/ALOX5AP/ST8SIA4/RXRA/PYGL/ARHGDIA	11
GO:0045182	translation regulator activity	9/922	140/18367	0.270671703050654	0.603487419556815	PABPC1/RPS9/EIF1/EIF4EBP1/CNBP/EIF2S3/EIF3K/EEF2/CELF1	9
GO:0003727	single-stranded RNA binding	6/922	87/18367	0.271490501107003	0.603772768365193	PABPC1/TLR8/CNBP/IFIH1/HNRNPU/DDX3X	6
GO:0001098	basal transcription machinery binding	5/922	70/18367	0.274540212486647	0.607090898181065	AHR/DRAP1/HNRNPU/PCF11/WAC	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/922	70/18367	0.274540212486647	0.607090898181065	AHR/DRAP1/HNRNPU/PCF11/WAC	5
GO:0016746	acyltransferase activity	15/922	250/18367	0.275066356612931	0.607090898181065	SAT1/LPGAT1/LPCAT2/GLUL/SPTLC2/ELOVL5/SAT2/ZDHHC20/MBOAT7/MSL3/KMT2C/TAF10/CREBBP/EP300/EPC1	15
GO:0016651	oxidoreductase activity, acting on NAD(P)H	6/922	88/18367	0.280168660154153	0.614181947895465	CYBB/CYBA/NCF1/NCF2/CYB5R4/NQO2	6
GO:0015035	protein-disulfide reductase activity	3/922	37/18367	0.283661102759484	0.614181947895465	SCO2/GLRX/PGK1	3
GO:0016409	palmitoyltransferase activity	3/922	37/18367	0.283661102759484	0.614181947895465	GLUL/SPTLC2/ZDHHC20	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3/922	37/18367	0.283661102759484	0.614181947895465	ALDH2/ALDH1A1/FAR1	3
GO:0001614	purinergic nucleotide receptor activity	2/922	21/18367	0.284603763040805	0.614181947895465	P2RY13/PTAFR	2
GO:0016502	nucleotide receptor activity	2/922	21/18367	0.284603763040805	0.614181947895465	P2RY13/PTAFR	2
GO:0051428	peptide hormone receptor binding	2/922	21/18367	0.284603763040805	0.614181947895465	JAK2/FYN	2
GO:0070577	lysine-acetylated histone binding	2/922	21/18367	0.284603763040805	0.614181947895465	PHIP/KMT2A	2
GO:0140033	acetylation-dependent protein binding	2/922	21/18367	0.284603763040805	0.614181947895465	PHIP/KMT2A	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4/922	54/18367	0.28644232451765	0.616627072976418	KDM6B/TET2/KDM7A/KDM5A	4
GO:0008017	microtubule binding	16/922	271/18367	0.287527468549852	0.617442278900664	S100A9/S100A8/LRRK2/MX1/MX2/CCDC88A/DPYSL2/GABARAP/CCDC69/NIN/CHP1/SUN2/CEP350/PRNP/HOOK3/ZNF207	16
GO:0019888	protein phosphatase regulator activity	6/922	89/18367	0.288908520990664	0.618887370945688	PHACTR1/PPP1R15A/CALM2/BOD1L1/PPP1R15B/SHOC2	6
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	8/922	125/18367	0.291517347646411	0.622949050960791	APOBEC3A/CDA/VNN2/GCH1/NAAA/ASAH1/MTHFD2/ADAR	8
GO:0030276	clathrin binding	5/922	72/18367	0.294158089561879	0.627058951895323	AP1S2/LRRK2/PICALM/SCLT1/AFTPH	5
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/922	38/18367	0.297563694847144	0.632725734821211	FKBP5/FKBP1A/FKBP15	3
GO:0005540	hyaluronic acid binding	2/922	22/18367	0.303506327855678	0.632725734821211	VCAN/CD44	2
GO:0008093	cytoskeletal anchor activity	2/922	22/18367	0.303506327855678	0.632725734821211	SDCBP/BICD2	2
GO:0008320	protein transmembrane transporter activity	2/922	22/18367	0.303506327855678	0.632725734821211	MCL1/TOMM7	2
GO:0009975	cyclase activity	2/922	22/18367	0.303506327855678	0.632725734821211	BST1/ADCY7	2
GO:0015645	fatty acid ligase activity	2/922	22/18367	0.303506327855678	0.632725734821211	ACSL1/ACSL4	2
GO:0017075	syntaxin-1 binding	2/922	22/18367	0.303506327855678	0.632725734821211	STXBP2/LRRK2	2
GO:0070034	telomerase RNA binding	2/922	22/18367	0.303506327855678	0.632725734821211	HNRNPU/XRN1	2
GO:0120020	cholesterol transfer activity	2/922	22/18367	0.303506327855678	0.632725734821211	TSPO/NPC2	2
GO:0070063	RNA polymerase binding	5/922	73/18367	0.304055845108591	0.632725734821211	ZFP36/HNRNPU/PCF11/WAC/TAF10	5
GO:0051287	NAD binding	4/922	56/18367	0.309306303058154	0.642122823925953	ALDH2/ALDH1A1/CTBP2/ME2	4
GO:0043130	ubiquitin binding	6/922	92/18367	0.31544304291761	0.65331094670614	TNFAIP3/UBE2L6/CXCR4/NUP62/NBR1/BIRC2	6
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/922	23/18367	0.322315911943159	0.664396478863965	PARP9/PARP14	2
GO:0120015	sterol transfer activity	2/922	23/18367	0.322315911943159	0.664396478863965	TSPO/NPC2	2
GO:0017080	sodium channel regulator activity	3/922	40/18367	0.325458784798542	0.669296418621002	FXYD5/SGK1/SCLT1	3
GO:0015078	proton transmembrane transporter activity	8/922	130/18367	0.328896711526728	0.674778699235588	SLC11A1/TCIRG1/HVCN1/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V0B/ATP6V1F	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	4/922	58/18367	0.332337061924876	0.678447050652823	MGST1/ALOX5AP/GSTK1/MAT2A	4
GO:0043021	ribonucleoprotein complex binding	9/922	149/18367	0.333013483672839	0.678447050652823	NEAT1/EIF1/DDX5/IFIH1/EIF3K/HNRNPU/EEF2/OXA1L/DDX3X	9
GO:0046906	tetrapyrrole binding	9/922	149/18367	0.333013483672839	0.678447050652823	CYBB/CYBA/PTGS2/CYP1B1/JAK2/BACH1/TBXAS1/CYB5R4/HMOX1	9
GO:0003713	transcription coactivator activity	15/922	262/18367	0.337487824040808	0.685124073880223	MTDH/LMO2/PRKCB/TRIM22/TRIM38/PKN1/NCOA4/CTBP2/DRAP1/ARID1A/KMT2C/CREBBP/EP300/KDM5A/BIRC2	15
GO:0016859	cis-trans isomerase activity	3/922	41/18367	0.339412581816171	0.685124073880223	FKBP5/FKBP1A/FKBP15	3
GO:0048487	beta-tubulin binding	3/922	41/18367	0.339412581816171	0.685124073880223	RGS2/GABARAP/TAOK1	3
GO:0003707	steroid hormone receptor activity	2/922	24/18367	0.340994247297365	0.685124073880223	RXRA/NR3C1	2
GO:0015252	proton channel activity	2/922	24/18367	0.340994247297365	0.685124073880223	HVCN1/ATP6V1A	2
GO:0050431	transforming growth factor beta binding	2/922	24/18367	0.340994247297365	0.685124073880223	CD36/TGFBR2	2
GO:0098631	cell adhesion mediator activity	4/922	59/18367	0.343886856253996	0.688120496525486	SIRPA/RAB10/NINJ1/EMB	4
GO:0003724	RNA helicase activity	5/922	77/18367	0.344060248262743	0.688120496525486	DDX60L/DDX5/IFIH1/DDX21/DDX3X	5
GO:0015036	disulfide oxidoreductase activity	3/922	42/18367	0.353346328086874	0.70342613698027	SCO2/GLRX/PGK1	3
GO:0019894	kinesin binding	3/922	42/18367	0.353346328086874	0.70342613698027	ACTB/SHTN1/NUP62	3
GO:0030971	receptor tyrosine kinase binding	5/922	78/18367	0.354127574681143	0.70342613698027	DOK2/DAZAP2/ITGAX/SH2B3/PTPN2	5
GO:0001786	phosphatidylserine binding	4/922	60/18367	0.355445234792281	0.704442483465881	CD300LF/CD300A/OSBPL8/TLN1	4
GO:0003887	DNA-directed DNA polymerase activity	2/922	25/18367	0.359507134063865	0.709275925895752	POLK/POLE4	2
GO:0034237	protein kinase A regulatory subunit binding	2/922	25/18367	0.359507134063865	0.709275925895752	PRKACA/PJA2	2
GO:0008186	ATP-dependent activity, acting on RNA	5/922	79/18367	0.364207026052854	0.715708835042418	DDX60L/DDX5/IFIH1/DDX21/DDX3X	5
GO:0004540	ribonuclease activity	7/922	116/18367	0.364405528139446	0.715708835042418	SAMHD1/RNASET2/RNASE6/NUDT16/DICER1/XRN2/XRN1	7
GO:0030544	Hsp70 protein binding	3/922	43/18367	0.367243044428881	0.719664620696955	SPN/NUP62/CREB1	3
GO:0005539	glycosaminoglycan binding	13/922	230/18367	0.370488459259908	0.724400253675973	VCAN/PTPRC/CD44/SELL/TLR2/NLRP3/HBEGF/SULF2/ADGRE2/GNS/TGFBR2/PRNP/ZNF207	13
GO:0004435	phosphatidylinositol phospholipase C activity	2/922	26/18367	0.377824129282374	0.730571435824767	CCR1/PLCB2	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2/922	26/18367	0.377824129282374	0.730571435824767	GLUL/ZDHHC20	2
GO:0019707	protein-cysteine S-acyltransferase activity	2/922	26/18367	0.377824129282374	0.730571435824767	GLUL/ZDHHC20	2
GO:0030371	translation repressor activity	2/922	26/18367	0.377824129282374	0.730571435824767	EIF4EBP1/CELF1	2
GO:0042974	retinoic acid receptor binding	2/922	26/18367	0.377824129282374	0.730571435824767	NR4A2/CTBP2	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3/922	44/18367	0.381086692052286	0.733052463850654	ALDH2/ALDH1A1/FAR1	3
GO:0004683	calmodulin-dependent protein kinase activity	2/922	27/18367	0.395918256573672	0.733052463850654	PTK2B/MAPKAPK3	2
GO:0008139	nuclear localization sequence binding	2/922	27/18367	0.395918256573672	0.733052463850654	NFKBIA/NUP214	2
GO:0015491	cation:cation antiporter activity	2/922	27/18367	0.395918256573672	0.733052463850654	SLC11A1/SLC8A1	2
GO:0016405	CoA-ligase activity	2/922	27/18367	0.395918256573672	0.733052463850654	ACSL1/ACSL4	2
GO:0022884	macromolecule transmembrane transporter activity	2/922	27/18367	0.395918256573672	0.733052463850654	MCL1/TOMM7	2
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/922	27/18367	0.395918256573672	0.733052463850654	INPP5D/PTEN	2
GO:0001094	TFIID-class transcription factor complex binding	1/922	10/18367	0.402591742160542	0.733052463850654	AHR	1
GO:0005384	manganese ion transmembrane transporter activity	1/922	10/18367	0.402591742160542	0.733052463850654	SLC11A1	1
GO:0005432	calcium:sodium antiporter activity	1/922	10/18367	0.402591742160542	0.733052463850654	SLC8A1	1
GO:0008097	5S rRNA binding	1/922	10/18367	0.402591742160542	0.733052463850654	EEF2	1
GO:0008172	S-methyltransferase activity	1/922	10/18367	0.402591742160542	0.733052463850654	KMT2A	1
GO:0008239	dipeptidyl-peptidase activity	1/922	10/18367	0.402591742160542	0.733052463850654	PRCP	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/922	10/18367	0.402591742160542	0.733052463850654	ATM	1
GO:0016595	glutamate binding	1/922	10/18367	0.402591742160542	0.733052463850654	GLUL	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/922	10/18367	0.402591742160542	0.733052463850654	CYB5R4	1
GO:0016803	ether hydrolase activity	1/922	10/18367	0.402591742160542	0.733052463850654	LTA4H	1
GO:0017002	activin-activated receptor activity	1/922	10/18367	0.402591742160542	0.733052463850654	TGFBR2	1
GO:0019203	carbohydrate phosphatase activity	1/922	10/18367	0.402591742160542	0.733052463850654	FBP1	1
GO:0030957	Tat protein binding	1/922	10/18367	0.402591742160542	0.733052463850654	ACTB	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/922	10/18367	0.402591742160542	0.733052463850654	ACSL4	1
GO:0035374	chondroitin sulfate binding	1/922	10/18367	0.402591742160542	0.733052463850654	ADGRE2	1
GO:0035612	AP-2 adaptor complex binding	1/922	10/18367	0.402591742160542	0.733052463850654	BMP2K	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/922	10/18367	0.402591742160542	0.733052463850654	PIK3AP1	1
GO:0045294	alpha-catenin binding	1/922	10/18367	0.402591742160542	0.733052463850654	NUMB	1
GO:0046030	inositol trisphosphate phosphatase activity	1/922	10/18367	0.402591742160542	0.733052463850654	INPP5D	1
GO:0050308	sugar-phosphatase activity	1/922	10/18367	0.402591742160542	0.733052463850654	FBP1	1
GO:0051864	histone H3-methyl-lysine-36 demethylase activity	1/922	10/18367	0.402591742160542	0.733052463850654	KDM7A	1
GO:0001968	fibronectin binding	2/922	28/18367	0.413765735455874	0.737017472656865	CTSS/ITGA4	2
GO:0004629	phospholipase C activity	2/922	28/18367	0.413765735455874	0.737017472656865	CCR1/PLCB2	2
GO:0008187	poly-pyrimidine tract binding	2/922	28/18367	0.413765735455874	0.737017472656865	PABPC1/HNRNPU	2
GO:0017056	structural constituent of nuclear pore	2/922	28/18367	0.413765735455874	0.737017472656865	NUP214/NUP62	2
GO:0043236	laminin binding	2/922	28/18367	0.413765735455874	0.737017472656865	CTSS/LGALS1	2
GO:0035254	glutamate receptor binding	3/922	47/18367	0.422152690565507	0.737017472656865	FYN/PTEN/PRNP	3
GO:0003697	single-stranded DNA binding	7/922	123/18367	0.422456324189382	0.737017472656865	SAMHD1/FAM111A/CNBP/PCBP2/YBX1/NABP1/HNRNPU	7
GO:0008013	beta-catenin binding	5/922	85/18367	0.424563136146921	0.737017472656865	KLF4/NR4A2/NUMB/KDM6B/EP300	5
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	2/922	29/18367	0.431345729054164	0.737017472656865	BLVRB/MTHFD2	2
GO:0000774	adenyl-nucleotide exchange factor activity	1/922	11/18367	0.432597212211638	0.737017472656865	PFN1	1
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/922	11/18367	0.432597212211638	0.737017472656865	BCL6	1
GO:0002162	dystroglycan binding	1/922	11/18367	0.432597212211638	0.737017472656865	PLEC	1
GO:0004016	adenylate cyclase activity	1/922	11/18367	0.432597212211638	0.737017472656865	ADCY7	1
GO:0004143	diacylglycerol kinase activity	1/922	11/18367	0.432597212211638	0.737017472656865	DGKZ	1
GO:0005049	nuclear export signal receptor activity	1/922	11/18367	0.432597212211638	0.737017472656865	NUP214	1
GO:0005347	ATP transmembrane transporter activity	1/922	11/18367	0.432597212211638	0.737017472656865	SLC25A24	1
GO:0008503	benzodiazepine receptor activity	1/922	11/18367	0.432597212211638	0.737017472656865	TSPO	1
GO:0015368	calcium:cation antiporter activity	1/922	11/18367	0.432597212211638	0.737017472656865	SLC8A1	1
GO:0016801	hydrolase activity, acting on ether bonds	1/922	11/18367	0.432597212211638	0.737017472656865	LTA4H	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/922	11/18367	0.432597212211638	0.737017472656865	DSE	1
GO:0017128	phospholipid scramblase activity	1/922	11/18367	0.432597212211638	0.737017472656865	PLSCR1	1
GO:0019107	myristoyltransferase activity	1/922	11/18367	0.432597212211638	0.737017472656865	ZDHHC20	1
GO:0019855	calcium channel inhibitor activity	1/922	11/18367	0.432597212211638	0.737017472656865	CALM2	1
GO:0031996	thioesterase binding	1/922	11/18367	0.432597212211638	0.737017472656865	CDC42	1
GO:0032052	bile acid binding	1/922	11/18367	0.432597212211638	0.737017472656865	PYGL	1
GO:0043295	glutathione binding	1/922	11/18367	0.432597212211638	0.737017472656865	MGST1	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/922	11/18367	0.432597212211638	0.737017472656865	NUDT16	1
GO:0061665	SUMO ligase activity	1/922	11/18367	0.432597212211638	0.737017472656865	PIAS1	1
GO:0070513	death domain binding	1/922	11/18367	0.432597212211638	0.737017472656865	MCL1	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/922	11/18367	0.432597212211638	0.737017472656865	SIRPA	1
GO:0097157	pre-mRNA intronic binding	1/922	11/18367	0.432597212211638	0.737017472656865	EP300	1
GO:0099186	structural constituent of postsynapse	1/922	11/18367	0.432597212211638	0.737017472656865	ACTB	1
GO:1990459	transferrin receptor binding	1/922	11/18367	0.432597212211638	0.737017472656865	SNX2	1
GO:0070888	E-box binding	3/922	48/18367	0.435642038029697	0.739322604345544	AHR/HIF1A/MAX	3
GO:0120013	lipid transfer activity	3/922	48/18367	0.435642038029697	0.739322604345544	TSPO/NPC2/OSBPL8	3
GO:0009055	electron transfer activity	7/922	126/18367	0.447228126041342	0.752242973934783	CYBB/CYBA/NCF1/NCF2/ALDH2/NQO2/ME2	7
GO:0016417	S-acyltransferase activity	2/922	30/18367	0.448640109042548	0.752242973934783	GLUL/ZDHHC20	2
GO:0046966	thyroid hormone receptor binding	2/922	30/18367	0.448640109042548	0.752242973934783	JMJD1C/TRIP12	2
GO:0070566	adenylyltransferase activity	2/922	30/18367	0.448640109042548	0.752242973934783	OAS1/OAS2	2
GO:0098632	cell-cell adhesion mediator activity	3/922	49/18367	0.449011743279998	0.752242973934783	SIRPA/RAB10/EMB	3
GO:0090079	translation regulator activity, nucleic acid binding	6/922	108/18367	0.459628324498306	0.752242973934783	PABPC1/EIF1/EIF2S3/EIF3K/EEF2/CELF1	6
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/922	12/18367	0.461097177909006	0.752242973934783	CDKN1A	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/922	12/18367	0.461097177909006	0.752242973934783	TGFBR2	1
GO:0005165	neurotrophin receptor binding	1/922	12/18367	0.461097177909006	0.752242973934783	GRB2	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/922	12/18367	0.461097177909006	0.752242973934783	MAPK1	1
GO:0008429	phosphatidylethanolamine binding	1/922	12/18367	0.461097177909006	0.752242973934783	CD300A	1
GO:0015166	polyol transmembrane transporter activity	1/922	12/18367	0.461097177909006	0.752242973934783	AQP9	1
GO:0017166	vinculin binding	1/922	12/18367	0.461097177909006	0.752242973934783	TLN1	1
GO:0033130	acetylcholine receptor binding	1/922	12/18367	0.461097177909006	0.752242973934783	JAK2	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/922	12/18367	0.461097177909006	0.752242973934783	ATM	1
GO:0089720	caspase binding	1/922	12/18367	0.461097177909006	0.752242973934783	CARD16	1
GO:1900750	oligopeptide binding	1/922	12/18367	0.461097177909006	0.752242973934783	MGST1	1
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	1/922	12/18367	0.461097177909006	0.752242973934783	KCNE3	1
GO:0000993	RNA polymerase II complex binding	3/922	50/18367	0.462251081845773	0.752242973934783	HNRNPU/PCF11/WAC	3
GO:0015485	cholesterol binding	3/922	50/18367	0.462251081845773	0.752242973934783	TSPO/NPC2/OSBPL8	3
GO:0008081	phosphoric diester hydrolase activity	5/922	89/18367	0.464234250362731	0.752242973934783	GPCPD1/CCR1/PLCB2/GNB1/HMOX1	5
GO:0043178	alcohol binding	5/922	89/18367	0.464234250362731	0.752242973934783	TSPO/RBP7/NPC2/OSBPL8/ADAP2	5
GO:0016878	acid-thiol ligase activity	2/922	31/18367	0.465633236726222	0.752242973934783	ACSL1/ACSL4	2
GO:0071813	lipoprotein particle binding	2/922	31/18367	0.465633236726222	0.752242973934783	CD36/SORL1	2
GO:0071814	protein-lipid complex binding	2/922	31/18367	0.465633236726222	0.752242973934783	CD36/SORL1	2
GO:0140318	protein transporter activity	2/922	31/18367	0.465633236726222	0.752242973934783	MCL1/TOMM7	2
GO:0042626	ATPase-coupled transmembrane transporter activity	6/922	109/18367	0.468516757241506	0.752483323707791	TAP1/TAPBP/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	6
GO:0003743	translation initiation factor activity	3/922	51/18367	0.475350138981183	0.752483323707791	EIF1/EIF2S3/EIF3K	3
GO:0030515	snoRNA binding	2/922	32/18367	0.482311759239137	0.752483323707791	NUDT16/DDX21	2
GO:0050699	WW domain binding	2/922	32/18367	0.482311759239137	0.752483323707791	DAZAP2/LITAF	2
GO:0140658	ATP-dependent chromatin remodeler activity	2/922	32/18367	0.482311759239137	0.752483323707791	CHD1/CHD9	2
GO:0032182	ubiquitin-like protein binding	6/922	111/18367	0.486169805611418	0.752483323707791	TNFAIP3/UBE2L6/CXCR4/NUP62/NBR1/BIRC2	6
GO:0004000	adenosine deaminase activity	1/922	13/18367	0.48816709901867	0.752483323707791	ADAR	1
GO:0004312	fatty acid synthase activity	1/922	13/18367	0.48816709901867	0.752483323707791	ELOVL5	1
GO:0008035	high-density lipoprotein particle binding	1/922	13/18367	0.48816709901867	0.752483323707791	CD36	1
GO:0008494	translation activator activity	1/922	13/18367	0.48816709901867	0.752483323707791	PABPC1	1
GO:0015250	water channel activity	1/922	13/18367	0.48816709901867	0.752483323707791	AQP9	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/922	13/18367	0.48816709901867	0.752483323707791	TRMT1	1
GO:0031386	protein tag	1/922	13/18367	0.48816709901867	0.752483323707791	ISG15	1
GO:0031432	titin binding	1/922	13/18367	0.48816709901867	0.752483323707791	CALM2	1
GO:0032036	myosin heavy chain binding	1/922	13/18367	0.48816709901867	0.752483323707791	CORO1A	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/922	13/18367	0.48816709901867	0.752483323707791	INPP5D	1
GO:0039706	co-receptor binding	1/922	13/18367	0.48816709901867	0.752483323707791	LRRK2	1
GO:0042301	phosphate ion binding	1/922	13/18367	0.48816709901867	0.752483323707791	MTHFD2	1
GO:0045504	dynein heavy chain binding	1/922	13/18367	0.48816709901867	0.752483323707791	DYNC1LI1	1
GO:0051011	microtubule minus-end binding	1/922	13/18367	0.48816709901867	0.752483323707791	NIN	1
GO:0060590	ATPase regulator activity	1/922	13/18367	0.48816709901867	0.752483323707791	PFN1	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/922	13/18367	0.48816709901867	0.752483323707791	CCNY	1
GO:0061783	peptidoglycan muralytic activity	1/922	13/18367	0.48816709901867	0.752483323707791	LYZ	1
GO:0070700	BMP receptor binding	1/922	13/18367	0.48816709901867	0.752483323707791	PYCARD	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/922	13/18367	0.48816709901867	0.752483323707791	HSD17B11	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/922	13/18367	0.48816709901867	0.752483323707791	INPP5D	1
GO:0005506	iron ion binding	8/922	151/18367	0.489547511758052	0.753282614923481	FTL/CYP1B1/FTH1/ALOX5/TBXAS1/FBXL5/TET2/KDM7A	8
GO:0003678	DNA helicase activity	4/922	72/18367	0.491412379024943	0.75482323245659	SETX/CHD1/CHD9/DDX3X	4
GO:0008200	ion channel inhibitor activity	2/922	33/18367	0.498664419893444	0.764618777169947	CALM2/WNK1	2
GO:0017069	snRNA binding	3/922	53/18367	0.501091643303702	0.765020348081942	HNRNPU/LSM10/DDX21	3
GO:0072341	modified amino acid binding	5/922	93/18367	0.503047116036896	0.765020348081942	MGST1/CD300LF/CD300A/OSBPL8/TLN1	5
GO:0004843	thiol-dependent deubiquitinase	6/922	113/18367	0.503633779463158	0.765020348081942	TNFAIP3/USP15/USP3/OTUD1/CYLD/TANK	6
GO:0001653	peptide receptor activity	8/922	153/18367	0.504534835668427	0.765020348081942	FPR1/AGTRAP/CX3CR1/CCR1/CCR2/CXCR4/OGFRL1/OGFR	8
GO:0101005	deubiquitinase activity	6/922	114/18367	0.512286349263021	0.765020348081942	TNFAIP3/USP15/USP3/OTUD1/CYLD/TANK	6
GO:0008374	O-acyltransferase activity	3/922	54/18367	0.513718073820528	0.765020348081942	LPGAT1/LPCAT2/MBOAT7	3
GO:0004065	arylsulfatase activity	1/922	14/18367	0.5138786569736	0.765020348081942	SULF2	1
GO:0004707	MAP kinase activity	1/922	14/18367	0.5138786569736	0.765020348081942	MAPK1	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/922	14/18367	0.5138786569736	0.765020348081942	PPT1	1
GO:0019992	diacylglycerol binding	1/922	14/18367	0.5138786569736	0.765020348081942	RASGRP2	1
GO:0032977	membrane insertase activity	1/922	14/18367	0.5138786569736	0.765020348081942	OXA1L	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/922	14/18367	0.5138786569736	0.765020348081942	HSD17B11	1
GO:0098599	palmitoyl hydrolase activity	1/922	14/18367	0.5138786569736	0.765020348081942	PPT1	1
GO:0140666	annealing activity	1/922	14/18367	0.5138786569736	0.765020348081942	DDX3X	1
GO:0016248	channel inhibitor activity	2/922	34/18367	0.514681881775952	0.765020348081942	CALM2/WNK1	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/922	34/18367	0.514681881775952	0.765020348081942	NUDT16/DICER1	2
GO:0045505	dynein intermediate chain binding	2/922	34/18367	0.514681881775952	0.765020348081942	DYNLT1/HOOK3	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/922	34/18367	0.514681881775952	0.765020348081942	INPP5D/PTEN	2
GO:0030170	pyridoxal phosphate binding	3/922	55/18367	0.526172134565651	0.779144315493027	KYNU/SPTLC2/PYGL	3
GO:0019787	ubiquitin-like protein transferase activity	23/922	458/18367	0.530126900732843	0.779144315493027	TNFAIP3/RNF213/RNF130/UBE2L6/TRIM22/RNF149/BIRC3/UBE2D1/FBXL5/TRIM38/RNF166/DTX3L/CDC42/ATG3/UBE2D3/UBE2R2/PIAS1/RNF141/RNF13/PJA2/MYCBP2/TRIP12/BIRC2	23
GO:0015298	solute:cation antiporter activity	2/922	35/18367	0.530356563741813	0.779144315493027	SLC11A1/SLC8A1	2
GO:0010851	cyclase regulator activity	1/922	15/18367	0.538299943862411	0.779144315493027	CALM2	1
GO:0015929	hexosaminidase activity	1/922	15/18367	0.538299943862411	0.779144315493027	NAGA	1
GO:0016846	carbon-sulfur lyase activity	1/922	15/18367	0.538299943862411	0.779144315493027	ALOX5AP	1
GO:0019215	intermediate filament binding	1/922	15/18367	0.538299943862411	0.779144315493027	VIM	1
GO:0042043	neurexin family protein binding	1/922	15/18367	0.538299943862411	0.779144315493027	SDCBP	1
GO:0042809	vitamin D receptor binding	1/922	15/18367	0.538299943862411	0.779144315493027	RXRA	1
GO:0045125	bioactive lipid receptor activity	1/922	15/18367	0.538299943862411	0.779144315493027	LPAR6	1
GO:0051139	metal ion:proton antiporter activity	1/922	15/18367	0.538299943862411	0.779144315493027	SLC11A1	1
GO:0070742	C2H2 zinc finger domain binding	1/922	15/18367	0.538299943862411	0.779144315493027	MBD2	1
GO:0071933	Arp2/3 complex binding	1/922	15/18367	0.538299943862411	0.779144315493027	GMFG	1
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	1/922	15/18367	0.538299943862411	0.779144315493027	KCNE3	1
GO:0050840	extracellular matrix binding	3/922	56/18367	0.538447558990604	0.779144315493027	CTSS/LGALS1/TGFBI	3
GO:0070279	vitamin B6 binding	3/922	56/18367	0.538447558990604	0.779144315493027	KYNU/SPTLC2/PYGL	3
GO:0000217	DNA secondary structure binding	2/922	36/18367	0.545682488007376	0.787007416697107	MEF2C/KMT2A	2
GO:0034061	DNA polymerase activity	2/922	36/18367	0.545682488007376	0.787007416697107	POLK/POLE4	2
GO:0043175	RNA polymerase core enzyme binding	3/922	57/18367	0.550538726786456	0.792703207926463	HNRNPU/PCF11/WAC	3
GO:0046915	transition metal ion transmembrane transporter activity	2/922	37/18367	0.56065513859297	0.79537632266773	SLC11A1/SLC31A2	2
GO:0071949	FAD binding	2/922	37/18367	0.56065513859297	0.79537632266773	KDM1B/NQO2	2
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/922	16/18367	0.561495641974816	0.79537632266773	CELF1	1
GO:0005372	water transmembrane transporter activity	1/922	16/18367	0.561495641974816	0.79537632266773	AQP9	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/922	16/18367	0.561495641974816	0.79537632266773	SLCO3A1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/922	16/18367	0.561495641974816	0.79537632266773	PIP4K2A	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/922	16/18367	0.561495641974816	0.79537632266773	DICER1	1
GO:0019841	retinol binding	1/922	16/18367	0.561495641974816	0.79537632266773	RBP7	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/922	16/18367	0.561495641974816	0.79537632266773	SOCS3	1
GO:1990380	Lys48-specific deubiquitinase activity	1/922	16/18367	0.561495641974816	0.79537632266773	USP15	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/922	58/18367	0.562440635778906	0.795425753512562	CD36/SLC16A3/MPC1	3
GO:0019838	growth factor binding	7/922	141/18367	0.566549958305889	0.79994291366615	DUSP1/CD36/IL1RN/IL10RA/IL6R/SDCBP/TGFBR2	7
GO:0005501	retinoid binding	2/922	38/18367	0.575271329912182	0.807041962027684	RBP7/RXRA	2
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/922	38/18367	0.575271329912182	0.807041962027684	DRAP1/TAF10	2
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	2/922	38/18367	0.575271329912182	0.807041962027684	XRN2/XRN1	2
GO:0019840	isoprenoid binding	2/922	38/18367	0.575271329912182	0.807041962027684	RBP7/RXRA	2
GO:0005324	long-chain fatty acid transporter activity	1/922	17/18367	0.583527194375188	0.808245273984016	CD36	1
GO:0015174	basic amino acid transmembrane transporter activity	1/922	17/18367	0.583527194375188	0.808245273984016	SLC7A7	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/922	17/18367	0.583527194375188	0.808245273984016	PPT1	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/922	17/18367	0.583527194375188	0.808245273984016	FTH1	1
GO:0016854	racemase and epimerase activity	1/922	17/18367	0.583527194375188	0.808245273984016	DSE	1
GO:0043395	heparan sulfate proteoglycan binding	1/922	17/18367	0.583527194375188	0.808245273984016	PTPRC	1
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	1/922	17/18367	0.583527194375188	0.808245273984016	ATP6V1A	1
GO:0046965	retinoid X receptor binding	1/922	17/18367	0.583527194375188	0.808245273984016	NR4A2	1
GO:0032934	sterol binding	3/922	60/18367	0.58565959181908	0.809915321597905	TSPO/NPC2/OSBPL8	3
GO:0004842	ubiquitin-protein transferase activity	21/922	433/18367	0.596925634697336	0.811508284356563	TNFAIP3/RNF213/RNF130/UBE2L6/TRIM22/RNF149/BIRC3/UBE2D1/FBXL5/TRIM38/RNF166/DTX3L/CDC42/UBE2D3/UBE2R2/RNF141/RNF13/PJA2/MYCBP2/TRIP12/BIRC2	21
GO:0005507	copper ion binding	3/922	61/18367	0.596969474905017	0.811508284356563	S100A12/SCO2/PRNP	3
GO:0043621	protein self-association	3/922	61/18367	0.596969474905017	0.811508284356563	TNFAIP3/MYD88/PLEC	3
GO:0019783	ubiquitin-like protein-specific protease activity	6/922	125/18367	0.603079928575798	0.811508284356563	TNFAIP3/USP15/USP3/OTUD1/CYLD/TANK	6
GO:0004532	exoribonuclease activity	2/922	40/18367	0.603427521692097	0.811508284356563	XRN2/XRN1	2
GO:0015144	carbohydrate transmembrane transporter activity	2/922	40/18367	0.603427521692097	0.811508284356563	SLC2A3/AQP9	2
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/922	40/18367	0.603427521692097	0.811508284356563	CYP1B1/HMOX1	2
GO:0031492	nucleosomal DNA binding	2/922	40/18367	0.603427521692097	0.811508284356563	ACTB/MBD2	2
GO:0043014	alpha-tubulin binding	2/922	40/18367	0.603427521692097	0.811508284356563	FYN/TAOK1	2
GO:0044183	protein folding chaperone	2/922	40/18367	0.603427521692097	0.811508284356563	CD74/HSPA1A	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/922	18/18367	0.604452966952086	0.811508284356563	SLC25A24	1
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/922	18/18367	0.604452966952086	0.811508284356563	HSD17B11	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/922	18/18367	0.604452966952086	0.811508284356563	PTEN	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/922	18/18367	0.604452966952086	0.811508284356563	SLC25A24	1
GO:0008301	DNA binding, bending	1/922	18/18367	0.604452966952086	0.811508284356563	HHEX	1
GO:0045236	CXCR chemokine receptor binding	1/922	18/18367	0.604452966952086	0.811508284356563	CXCL8	1
GO:0050811	GABA receptor binding	1/922	18/18367	0.604452966952086	0.811508284356563	GABARAP	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/922	18/18367	0.604452966952086	0.811508284356563	RAB10	1
GO:0140597	protein carrier activity	1/922	18/18367	0.604452966952086	0.811508284356563	OXA1L	1
GO:0008242	omega peptidase activity	6/922	126/18367	0.61087251870252	0.818868989794483	TNFAIP3/USP15/USP3/OTUD1/CYLD/TANK	6
GO:0008135	translation factor activity, RNA binding	4/922	84/18367	0.613970954567646	0.821100356017325	EIF1/EIF2S3/EIF3K/EEF2	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/922	41/18367	0.616966749378042	0.821100356017325	ACSL1/ACSL4	2
GO:0050660	flavin adenine dinucleotide binding	4/922	85/18367	0.62332442708225	0.821100356017325	CYBB/DPYD/KDM1B/NQO2	4
GO:0003746	translation elongation factor activity	1/922	19/18367	0.624328402369284	0.821100356017325	EEF2	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/922	19/18367	0.624328402369284	0.821100356017325	TGFBR2	1
GO:0004970	ionotropic glutamate receptor activity	1/922	19/18367	0.624328402369284	0.821100356017325	PTK2B	1
GO:0016918	retinal binding	1/922	19/18367	0.624328402369284	0.821100356017325	RBP7	1
GO:0035613	RNA stem-loop binding	1/922	19/18367	0.624328402369284	0.821100356017325	DDX3X	1
GO:0035615	clathrin adaptor activity	1/922	19/18367	0.624328402369284	0.821100356017325	AP1S2	1
GO:0052742	phosphatidylinositol kinase activity	1/922	19/18367	0.624328402369284	0.821100356017325	ATM	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/922	19/18367	0.624328402369284	0.821100356017325	PTEN	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	8/922	170/18367	0.624772167986938	0.821100356017325	PTGS2/CYP1B1/TBXAS1/KDM6B/HMOX1/TET2/KDM7A/KDM5A	8
GO:0008236	serine-type peptidase activity	9/922	191/18367	0.624919331374732	0.821100356017325	CTSS/CFD/TPP1/CTSH/CPVL/SCPEP1/PRCP/CTSA/SEC11A	9
GO:0061659	ubiquitin-like protein ligase activity	15/922	316/18367	0.6256897449743	0.821100356017325	RNF130/TRIM22/RNF149/BIRC3/UBE2D1/TRIM38/RNF166/DTX3L/CDC42/UBE2D3/PIAS1/RNF13/MYCBP2/TRIP12/BIRC2	15
GO:0016836	hydro-lyase activity	3/922	64/18367	0.629668435891086	0.825082778064182	CYP1B1/HACD4/TBXAS1	3
GO:0042562	hormone binding	4/922	86/18367	0.632533247849047	0.827595896137825	TSPO/CTSH/ALDH1A1/NR3C1	4
GO:0018024	histone-lysine N-methyltransferase activity	2/922	43/18367	0.642972391223758	0.83160087184313	KMT2C/KMT2A	2
GO:0001972	retinoic acid binding	1/922	20/18367	0.643206166322604	0.83160087184313	RXRA	1
GO:0004551	nucleotide diphosphatase activity	1/922	20/18367	0.643206166322604	0.83160087184313	NUDT3	1
GO:0016018	cyclosporin A binding	1/922	20/18367	0.643206166322604	0.83160087184313	PPP3CA	1
GO:0016408	C-acyltransferase activity	1/922	20/18367	0.643206166322604	0.83160087184313	SPTLC2	1
GO:0031690	adrenergic receptor binding	1/922	20/18367	0.643206166322604	0.83160087184313	ARRB2	1
GO:0070300	phosphatidic acid binding	1/922	20/18367	0.643206166322604	0.83160087184313	NRGN	1
GO:0140312	cargo adaptor activity	1/922	20/18367	0.643206166322604	0.83160087184313	AP1S2	1
GO:0017171	serine hydrolase activity	9/922	195/18367	0.649434072151669	0.83841267217217	CTSS/CFD/TPP1/CTSH/CPVL/SCPEP1/PRCP/CTSA/SEC11A	9
GO:0043022	ribosome binding	3/922	66/18367	0.650424472078462	0.838452785540672	EIF3K/EEF2/OXA1L	3
GO:0008375	acetylglucosaminyltransferase activity	2/922	44/18367	0.655443138803351	0.843677913570146	LFNG/MGAT1	2
GO:0051117	ATPase binding	4/922	89/18367	0.659276540996362	0.84478525495522	SNX10/TCIRG1/RALB/PPP3CA	4
GO:0008373	sialyltransferase activity	1/922	21/18367	0.661136286486694	0.84478525495522	ST8SIA4	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/922	21/18367	0.661136286486694	0.84478525495522	SLC25A24	1
GO:0019200	carbohydrate kinase activity	1/922	21/18367	0.661136286486694	0.84478525495522	NAGK	1
GO:1990381	ubiquitin-specific protease binding	1/922	21/18367	0.661136286486694	0.84478525495522	PTEN	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/922	45/18367	0.667563184248354	0.850292330151562	NUDT16/DICER1	2
GO:0140223	general transcription initiation factor activity	2/922	45/18367	0.667563184248354	0.850292330151562	DRAP1/TAF10	2
GO:0061630	ubiquitin protein ligase activity	14/922	304/18367	0.668364794981835	0.850292330151562	RNF130/TRIM22/RNF149/BIRC3/UBE2D1/TRIM38/RNF166/DTX3L/CDC42/UBE2D3/RNF13/MYCBP2/TRIP12/BIRC2	14
GO:0003684	damaged DNA binding	3/922	68/18367	0.670337050649324	0.850325953944135	POLK/CREBBP/EP300	3
GO:0019843	rRNA binding	3/922	68/18367	0.670337050649324	0.850325953944135	RPS9/EEF2/DDX21	3
GO:0005355	glucose transmembrane transporter activity	1/922	22/18367	0.678166284516743	0.853878557976319	SLC2A3	1
GO:0005537	mannose binding	1/922	22/18367	0.678166284516743	0.853878557976319	CLEC4A	1
GO:0015149	hexose transmembrane transporter activity	1/922	22/18367	0.678166284516743	0.853878557976319	SLC2A3	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/922	22/18367	0.678166284516743	0.853878557976319	VCAN	1
GO:0055106	ubiquitin-protein transferase regulator activity	1/922	22/18367	0.678166284516743	0.853878557976319	TRIB1	1
GO:0004864	protein phosphatase inhibitor activity	2/922	46/18367	0.679336271728292	0.853878557976319	PHACTR1/BOD1L1	2
GO:0004521	endoribonuclease activity	3/922	69/18367	0.679976517564666	0.853878557976319	RNASET2/NUDT16/DICER1	3
GO:0003730	mRNA 3'-UTR binding	9/922	201/18367	0.684451296409275	0.858264609844628	ZFP36/ZFP36L2/PABPC1/CELF2/ZFP36L1/DDX5/ZNF385A/HNRNPU/CELF1	9
GO:0005044	scavenger receptor activity	2/922	47/18367	0.690766653113305	0.860786237544632	CD36/CD163	2
GO:0005212	structural constituent of eye lens	1/922	23/18367	0.694341301451906	0.860786237544632	VIM	1
GO:0015299	solute:proton antiporter activity	1/922	23/18367	0.694341301451906	0.860786237544632	SLC11A1	1
GO:0030552	cAMP binding	1/922	23/18367	0.694341301451906	0.860786237544632	PRKAR1A	1
GO:0047617	acyl-CoA hydrolase activity	1/922	23/18367	0.694341301451906	0.860786237544632	PPT1	1
GO:0050750	low-density lipoprotein particle receptor binding	1/922	23/18367	0.694341301451906	0.860786237544632	PICALM	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/922	23/18367	0.694341301451906	0.860786237544632	TNFAIP3	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/922	23/18367	0.694341301451906	0.860786237544632	MGAT1	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/922	71/18367	0.698623586134098	0.863644998983312	VNN2/NAAA/ASAH1	3
GO:0031491	nucleosome binding	3/922	71/18367	0.698623586134098	0.863644998983312	ACTB/MBD2/ARID1A	3
GO:0015145	monosaccharide transmembrane transporter activity	1/922	24/18367	0.709704216849929	0.872407152639716	SLC2A3	1
GO:0019789	SUMO transferase activity	1/922	24/18367	0.709704216849929	0.872407152639716	PIAS1	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/922	24/18367	0.709704216849929	0.872407152639716	PYCARD	1
GO:0070840	dynein complex binding	1/922	24/18367	0.709704216849929	0.872407152639716	BICD2	1
GO:0019212	phosphatase inhibitor activity	2/922	49/18367	0.712618486592888	0.874759209665989	PHACTR1/BOD1L1	2
GO:0140104	molecular carrier activity	3/922	73/18367	0.716433875124057	0.877995140025377	NUP214/SCO2/OXA1L	3
GO:0005048	signal sequence binding	2/922	50/18367	0.723050461790684	0.877995140025377	NFKBIA/NUP214	2
GO:0140359	ABC-type transporter activity	2/922	50/18367	0.723050461790684	0.877995140025377	TAP1/TAPBP	2
GO:0008170	N-methyltransferase activity	4/922	97/18367	0.723971822531642	0.877995140025377	TRMT1/HNMT/KMT2C/KMT2A	4
GO:0005112	Notch binding	1/922	25/18367	0.724295761966015	0.877995140025377	ADAM17	1
GO:0008266	poly(U) RNA binding	1/922	25/18367	0.724295761966015	0.877995140025377	PABPC1	1
GO:0008327	methyl-CpG binding	1/922	25/18367	0.724295761966015	0.877995140025377	MBD2	1
GO:0016289	CoA hydrolase activity	1/922	25/18367	0.724295761966015	0.877995140025377	PPT1	1
GO:0070330	aromatase activity	1/922	25/18367	0.724295761966015	0.877995140025377	CYP1B1	1
GO:0048018	receptor ligand activity	22/922	487/18367	0.726121516873409	0.878989204636232	IL1B/TYMP/CCL3L3/GMFG/TNFSF13B/NAMPT/CCL3/TIMP1/TNFSF10/CXCL8/RETN/SECTM1/IL1RN/GRN/TGFB1/HBEGF/TNF/CCL4/METRNL/CMTM7/CMTM3/CKLF	22
GO:0042923	neuropeptide binding	1/922	26/18367	0.738154627273361	0.8923197015725	SORL1	1
GO:0008237	metallopeptidase activity	8/922	190/18367	0.743295104234825	0.896779977323524	LAP3/LTA4H/NUDT16/AGTPBP1/RNPEPL1/ADAM10/LNPEP/ADAM17	8
GO:0005496	steroid binding	4/922	100/18367	0.745741781286389	0.896779977323524	TSPO/NPC2/OSBPL8/NR3C1	4
GO:0008066	glutamate receptor activity	1/922	27/18367	0.751317564607964	0.896779977323524	PTK2B	1
GO:0015215	nucleotide transmembrane transporter activity	1/922	27/18367	0.751317564607964	0.896779977323524	SLC25A24	1
GO:0035255	ionotropic glutamate receptor binding	1/922	27/18367	0.751317564607964	0.896779977323524	PTEN	1
GO:0048027	mRNA 5'-UTR binding	1/922	27/18367	0.751317564607964	0.896779977323524	DDX3X	1
GO:0051119	sugar transmembrane transporter activity	1/922	27/18367	0.751317564607964	0.896779977323524	SLC2A3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	5/922	124/18367	0.751898174953126	0.896779977323524	HSD17B11/G6PD/PGD/CTBP2/ME2	5
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/922	53/18367	0.75243995687453	0.896779977323524	AQP9/SLC16A3	2
GO:0030546	signaling receptor activator activity	22/922	495/18367	0.752840591662652	0.896779977323524	IL1B/TYMP/CCL3L3/GMFG/TNFSF13B/NAMPT/CCL3/TIMP1/TNFSF10/CXCL8/RETN/SECTM1/IL1RN/GRN/TGFB1/HBEGF/TNF/CCL4/METRNL/CMTM7/CMTM3/CKLF	22
GO:0008528	G protein-coupled peptide receptor activity	6/922	147/18367	0.753131010704195	0.896779977323524	FPR1/AGTRAP/CX3CR1/CCR1/CCR2/CXCR4	6
GO:0070325	lipoprotein particle receptor binding	1/922	28/18367	0.76381948420619	0.907035637494851	PICALM	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/922	28/18367	0.76381948420619	0.907035637494851	HERPUD1	1
GO:0016835	carbon-oxygen lyase activity	3/922	79/18367	0.764964556609667	0.907162852750135	CYP1B1/HACD4/TBXAS1	3
GO:0004620	phospholipase activity	4/922	104/18367	0.772696708505015	0.912457819625877	CCR1/PLCB2/PLBD1/HMOX1	4
GO:0016829	lyase activity	8/922	196/18367	0.773246775380113	0.912457819625877	CYP1B1/RNASET2/HACD4/BST1/TBXAS1/ALOX5AP/ADCY7/ME2	8
GO:0004181	metallocarboxypeptidase activity	1/922	29/18367	0.775693546890191	0.912457819625877	AGTPBP1	1
GO:0033612	receptor serine/threonine kinase binding	1/922	29/18367	0.775693546890191	0.912457819625877	PYCARD	1
GO:0051787	misfolded protein binding	1/922	29/18367	0.775693546890191	0.912457819625877	HSPA1A	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/922	29/18367	0.775693546890191	0.912457819625877	OSBPL8	1
GO:0030374	nuclear receptor coactivator activity	2/922	56/18367	0.779101225849129	0.914006001868642	PRKCB/PKN1	2
GO:0042054	histone methyltransferase activity	2/922	56/18367	0.779101225849129	0.914006001868642	KMT2C/KMT2A	2
GO:0016298	lipase activity	5/922	129/18367	0.781738356610298	0.915870407074264	CCR1/PLCB2/PLBD1/LIPA/HMOX1	5
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/922	30/18367	0.786971251643558	0.920051608530121	HSD17B11	1
GO:0005548	phospholipid transporter activity	2/922	57/18367	0.787412589451408	0.920051608530121	PLSCR1/OSBPL8	2
GO:0051087	chaperone binding	4/922	107/18367	0.791399246235713	0.92347522190923	HLA-B/GRN/PRNP/BIRC2	4
GO:0090482	vitamin transmembrane transporter activity	1/922	31/18367	0.797682518807469	0.928328257573539	SLC2A3	1
GO:0140142	nucleocytoplasmic carrier activity	1/922	31/18367	0.797682518807469	0.928328257573539	NUP214	1
GO:0016279	protein-lysine N-methyltransferase activity	2/922	59/18367	0.803212159209405	0.932280779746374	KMT2C/KMT2A	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/922	59/18367	0.803212159209405	0.932280779746374	XRN2/XRN1	2
GO:0008175	tRNA methyltransferase activity	1/922	32/18367	0.807855769116125	0.932715907803822	TRMT1	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/922	32/18367	0.807855769116125	0.932715907803822	SLC25A24	1
GO:0030332	cyclin binding	1/922	32/18367	0.807855769116125	0.932715907803822	CDKN1A	1
GO:0048019	receptor antagonist activity	1/922	32/18367	0.807855769116125	0.932715907803822	IL1RN	1
GO:0016278	lysine N-methyltransferase activity	2/922	60/18367	0.810713971878037	0.934781017706338	KMT2C/KMT2A	2
GO:0043177	organic acid binding	5/922	135/18367	0.813795976115143	0.936551788906162	S100A9/S100A8/GLUL/ALOX5AP/RXRA	5
GO:0008094	ATP-dependent activity, acting on DNA	4/922	111/18367	0.814392859918401	0.936551788906162	SETX/CHD1/CHD9/DDX3X	4
GO:0005251	delayed rectifier potassium channel activity	1/922	33/18367	0.817517998779334	0.937865888599373	KCNE3	1
GO:0004175	endopeptidase activity	18/922	430/18367	0.818219061814713	0.937865888599373	CTSS/PYCARD/CFD/PSMB9/CASP1/PSMB8/USP15/TPP1/CTSH/CTSZ/CTSB/CAPN2/CAPNS1/PSMB10/CFLAR/ADAM10/ADAM17/SEC11A	18
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	5/922	136/18367	0.818754774601054	0.937865888599373	HSD17B11/G6PD/PGD/CTBP2/ME2	5
GO:0008376	acetylgalactosaminyltransferase activity	1/922	34/18367	0.826694850809739	0.943252349357326	CSGALNACT2	1
GO:0016229	steroid dehydrogenase activity	1/922	34/18367	0.826694850809739	0.943252349357326	HSD17B11	1
GO:0016831	carboxy-lyase activity	1/922	34/18367	0.826694850809739	0.943252349357326	ME2	1
GO:0008083	growth factor activity	6/922	162/18367	0.828751669309658	0.944366308965634	TYMP/GMFG/TIMP1/GRN/TGFB1/HBEGF	6
GO:0003774	cytoskeletal motor activity	4/922	114/18367	0.830240445160789	0.944830923268918	MYO1F/MYO1G/MYO9B/MYH9	4
GO:0004518	nuclease activity	8/922	210/18367	0.833075613587627	0.94682455952612	SAMHD1/RNASET2/RNASE6/PLSCR1/NUDT16/DICER1/XRN2/XRN1	8
GO:0000175	3'-5'-exoribonuclease activity	1/922	35/18367	0.835410682782325	0.948245372404873	XRN2	1
GO:0042162	telomeric DNA binding	1/922	36/18367	0.843688631204467	0.955160445171896	SMG1	1
GO:0042805	actinin binding	1/922	36/18367	0.843688631204467	0.955160445171896	NFKB1	1
GO:0005109	frizzled binding	1/922	37/18367	0.851550672665897	0.960329403754831	SDCBP	1
GO:0030551	cyclic nucleotide binding	1/922	37/18367	0.851550672665897	0.960329403754831	PRKAR1A	1
GO:0042056	chemoattractant activity	1/922	37/18367	0.851550672665897	0.960329403754831	CCL3	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	3/922	94/18367	0.857125197502424	0.963775935823354	LYZ/CTBS/NAGA	3
GO:0004520	endodeoxyribonuclease activity	1/922	38/18367	0.859017681929511	0.963775935823354	DICER1	1
GO:0008395	steroid hydroxylase activity	1/922	38/18367	0.859017681929511	0.963775935823354	CYP1B1	1
GO:0140303	intramembrane lipid transporter activity	1/922	38/18367	0.859017681929511	0.963775935823354	PLSCR1	1
GO:0016776	phosphotransferase activity, phosphate group as acceptor	1/922	39/18367	0.866109487115882	0.968004720894221	PPIP5K2	1
GO:0019825	oxygen binding	1/922	39/18367	0.866109487115882	0.968004720894221	SOD2	1
GO:0050997	quaternary ammonium group binding	1/922	39/18367	0.866109487115882	0.968004720894221	TKT	1
GO:0019842	vitamin binding	5/922	148/18367	0.870310708914915	0.971457930512945	RBP7/TKT/KYNU/SPTLC2/PYGL	5
GO:0016757	glycosyltransferase activity	10/922	270/18367	0.875973369394731	0.97643888184668	TYMP/NAMPT/LFNG/UPP1/PARP9/PARP14/CSGALNACT2/ST8SIA4/MGAT1/PYGL	10
GO:0004812	aminoacyl-tRNA ligase activity	1/922	41/18367	0.879241876445466	0.97643888184668	CARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/922	41/18367	0.879241876445466	0.97643888184668	CARS2	1
GO:0030331	estrogen receptor binding	1/922	41/18367	0.879241876445466	0.97643888184668	TAF10	1
GO:0016887	ATP hydrolysis activity	10/922	272/18367	0.881335809523794	0.977522204979436	RNF213/HSPA1A/SMCHD1/DDX60L/DDX5/CHD1/CHD9/IFIH1/DDX21/DDX3X	10
GO:0000049	tRNA binding	2/922	72/18367	0.882650416432704	0.977739498050929	TRMT1/EIF2S3	2
GO:0008307	structural constituent of muscle	1/922	42/18367	0.885317342445536	0.978214105306445	PLEC	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/922	42/18367	0.885317342445536	0.978214105306445	DPYD	1
GO:0005319	lipid transporter activity	5/922	154/18367	0.891064080181812	0.979382655492126	TSPO/CD36/NPC2/PLSCR1/OSBPL8	5
GO:0016790	thiolester hydrolase activity	1/922	43/18367	0.891087460331768	0.979382655492126	PPT1	1
GO:0030547	signaling receptor inhibitor activity	1/922	43/18367	0.891087460331768	0.979382655492126	IL1RN	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/922	43/18367	0.891087460331768	0.979382655492126	NCF4	1
GO:0004497	monooxygenase activity	3/922	102/18367	0.891977796077496	0.979382655492126	CYP1B1/TBXAS1/HMOX1	3
GO:0004519	endonuclease activity	4/922	129/18367	0.893443398508969	0.979761016683612	RNASET2/RNASE6/NUDT16/DICER1	4
GO:0015399	primary active transmembrane transporter activity	6/922	181/18367	0.896645931056684	0.981544525645646	TAP1/TAPBP/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5/922	156/18367	0.897315876419761	0.981544525645646	METTL9/TRMT1/HNMT/KMT2C/KMT2A	5
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/922	45/18367	0.901772205754795	0.984357873553988	NQO2	1
GO:0016853	isomerase activity	5/922	158/18367	0.903254579184915	0.984357873553988	TBXAS1/FKBP5/FKBP1A/FKBP15/DSE	5
GO:0016779	nucleotidyltransferase activity	4/922	132/18367	0.903266607082721	0.984357873553988	OAS1/OAS2/POLK/POLE4	4
GO:0008514	organic anion transmembrane transporter activity	6/922	185/18367	0.90756431080829	0.987809723096445	SLC2A3/CD36/SLCO3A1/SLC16A3/MPC1/SLC25A24	6
GO:0034987	immunoglobulin receptor binding	2/922	79/18367	0.911969887650184	0.991370251002812	FLNA/FGR	2
GO:0004527	exonuclease activity	2/922	80/18367	0.915549632515125	0.992925817369135	XRN2/XRN1	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/922	48/18367	0.915868286949982	0.992925817369135	GLUL	1
GO:0046943	carboxylic acid transmembrane transporter activity	5/922	163/18367	0.91680907850903	0.992925817369135	CD36/SLC7A7/AQP9/SLC16A3/MPC1	5
GO:0005342	organic acid transmembrane transporter activity	5/922	164/18367	0.919310098790995	0.994402260325903	CD36/SLC7A7/AQP9/SLC16A3/MPC1	5
GO:0016874	ligase activity	5/922	165/18367	0.921744502598549	0.995527996106199	ACSL1/GLUL/ATP6V1A/CARS2/ACSL4	5
GO:0140098	catalytic activity, acting on RNA	14/922	386/18367	0.922628920876454	0.995527996106199	SAMHD1/RNASET2/RNASE6/NUDT16/DDX60L/TRMT1/DDX5/CARS2/IFIH1/DICER1/XRN2/DDX21/DDX3X/XRN1	14
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/922	50/18367	0.924124131178511	0.995911825709024	SLC25A24	1
GO:0016860	intramolecular oxidoreductase activity	1/922	51/18367	0.927943400221117	0.996563920677462	TBXAS1	1
GO:0030165	PDZ domain binding	2/922	84/18367	0.928544583954088	0.996563920677462	PTEN/ADAM17	2
GO:0008146	sulfotransferase activity	1/922	52/18367	0.931570621502845	0.996563920677462	SULT1A1	1
GO:0016597	amino acid binding	1/922	52/18367	0.931570621502845	0.996563920677462	GLUL	1
GO:0016830	carbon-carbon lyase activity	1/922	52/18367	0.931570621502845	0.996563920677462	ME2	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/922	52/18367	0.931570621502845	0.996563920677462	TNFAIP3	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/922	53/18367	0.935015441976466	0.99902627907999	SLC25A24	1
GO:0005201	extracellular matrix structural constituent	5/922	172/18367	0.937036585469048	0.999963340292977	VCAN/FGL2/TGFBI/CD4/EMILIN2	5
GO:0008408	3'-5' exonuclease activity	1/922	54/18367	0.93828702450883	0.999999561785581	XRN2	1
GO:0008276	protein methyltransferase activity	2/922	88/18367	0.939634001317569	0.999999561785581	KMT2C/KMT2A	2
GO:0004252	serine-type endopeptidase activity	5/922	174/18367	0.940884013547776	0.999999561785581	CTSS/CFD/TPP1/CTSH/SEC11A	5
GO:0015297	antiporter activity	2/922	89/18367	0.942139553229732	0.999999561785581	SLC11A1/SLC8A1	2
GO:0140097	catalytic activity, acting on DNA	7/922	229/18367	0.945163224961985	0.999999561785581	SETX/POLK/CHD1/CHD9/DICER1/POLE4/DDX3X	7
GO:0004536	deoxyribonuclease activity	1/922	57/18367	0.947147212987297	0.999999561785581	DICER1	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/922	57/18367	0.947147212987297	0.999999561785581	NQO2	1
GO:0051082	unfolded protein binding	3/922	122/18367	0.948135110381249	0.999999561785581	PFDN5/TAPBP/HSPA1A	3
GO:0022824	transmitter-gated ion channel activity	1/922	60/18367	0.954736515763094	0.999999561785581	PTK2B	1
GO:0022835	transmitter-gated channel activity	1/922	60/18367	0.954736515763094	0.999999561785581	PTK2B	1
GO:0015179	L-amino acid transmembrane transporter activity	1/922	61/18367	0.957016131891703	0.999999561785581	SLC7A7	1
GO:1901681	sulfur compound binding	8/922	265/18367	0.958825920344097	0.999999561785581	PTPRC/SELL/SULT1A1/TKT/HBEGF/MGST1/ADGRE2/ZNF207	8
GO:0004867	serine-type endopeptidase inhibitor activity	2/922	98/18367	0.960642254756723	0.999999561785581	SERPINA1/SERPINB1	2
GO:0008173	RNA methyltransferase activity	1/922	65/18367	0.965043900606456	0.999999561785581	TRMT1	1
GO:0008201	heparin binding	4/922	166/18367	0.969822055418352	0.999999561785581	PTPRC/SELL/HBEGF/ZNF207	4
GO:0016782	transferase activity, transferring sulphur-containing groups	1/922	68/18367	0.970065441858079	0.999999561785581	SULT1A1	1
GO:0051536	iron-sulfur cluster binding	1/922	68/18367	0.970065441858079	0.999999561785581	DPYD	1
GO:0051540	metal cluster binding	1/922	68/18367	0.970065441858079	0.999999561785581	DPYD	1
GO:0016758	hexosyltransferase activity	5/922	197/18367	0.972137423196736	0.999999561785581	TYMP/LFNG/CSGALNACT2/MGAT1/PYGL	5
GO:0005244	voltage-gated ion channel activity	5/922	201/18367	0.975668519009487	0.999999561785581	CYBB/KCNE3/HVCN1/PTK2B/CLIC1	5
GO:0022832	voltage-gated channel activity	5/922	201/18367	0.975668519009487	0.999999561785581	CYBB/KCNE3/HVCN1/PTK2B/CLIC1	5
GO:0005230	extracellular ligand-gated ion channel activity	1/922	73/18367	0.976884809486325	0.999999561785581	PTK2B	1
GO:0008194	UDP-glycosyltransferase activity	3/922	143/18367	0.976997727681928	0.999999561785581	LFNG/CSGALNACT2/MGAT1	3
GO:0022843	voltage-gated cation channel activity	3/922	143/18367	0.976997727681928	0.999999561785581	KCNE3/HVCN1/PTK2B	3
GO:0004222	metalloendopeptidase activity	2/922	111/18367	0.977681712149039	0.999999561785581	ADAM10/ADAM17	2
GO:0030594	neurotransmitter receptor activity	2/922	111/18367	0.977681712149039	0.999999561785581	TSPO/PTK2B	2
GO:0005254	chloride channel activity	1/922	74/18367	0.97804979284992	0.999999561785581	CLIC1	1
GO:0052689	carboxylic ester hydrolase activity	3/922	147/18367	0.980378336617637	0.999999561785581	AOAH/PGLS/LIPA	3
GO:0022853	active ion transmembrane transporter activity	7/922	267/18367	0.982424261386454	0.999999561785581	SLC11A1/SLC8A1/SLCO3A1/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	7
GO:0003735	structural constituent of ribosome	4/922	182/18367	0.983181038648627	0.999999561785581	ISG15/RPS9/RPL28/RSL24D1	4
GO:0008168	methyltransferase activity	5/922	214/18367	0.984470488297975	0.999999561785581	METTL9/TRMT1/HNMT/KMT2C/KMT2A	5
GO:0005179	hormone activity	2/922	122/18367	0.986304354529654	0.999999561785581	RETN/METRNL	2
GO:0015171	amino acid transmembrane transporter activity	1/922	84/18367	0.986914788172248	0.999999561785581	SLC7A7	1
GO:0140101	catalytic activity, acting on a tRNA	2/922	124/18367	0.987476974665336	0.999999561785581	TRMT1/CARS2	2
GO:0005253	anion channel activity	1/922	87/18367	0.988796368754291	0.999999561785581	CLIC1	1
GO:0016741	transferase activity, transferring one-carbon groups	5/922	225/18367	0.989480581543471	0.999999561785581	METTL9/TRMT1/HNMT/KMT2C/KMT2A	5
GO:0005249	voltage-gated potassium channel activity	1/922	90/18367	0.990407639372564	0.999999561785581	KCNE3	1
GO:0008509	anion transmembrane transporter activity	7/922	314/18367	0.996257739551953	0.999999561785581	SLC2A3/CD36/SLCO3A1/SLC16A3/CLIC1/MPC1/SLC25A24	7
GO:0022804	active transmembrane transporter activity	10/922	406/18367	0.996899836514112	0.999999561785581	SLC11A1/SLC8A1/SLCO3A1/TAP1/TAPBP/SLC16A3/ATP6V1B2/ATP6V0D1/ATP6V1A/ATP6V1F	10
GO:0099094	ligand-gated cation channel activity	1/922	113/18367	0.997085533340538	0.999999561785581	PTK2B	1
GO:0005267	potassium channel activity	1/922	121/18367	0.998074920288026	0.999999561785581	KCNE3	1
GO:0015291	secondary active transmembrane transporter activity	4/922	240/18367	0.998245829244105	0.999999561785581	SLC11A1/SLC8A1/SLCO3A1/SLC16A3	4
GO:0015085	calcium ion transmembrane transporter activity	1/922	135/18367	0.999068762522845	0.999999561785581	SLC8A1	1
GO:0015276	ligand-gated ion channel activity	1/922	143/18367	0.99938520977235	0.999999561785581	PTK2B	1
GO:0022834	ligand-gated channel activity	1/922	143/18367	0.99938520977235	0.999999561785581	PTK2B	1
GO:0015293	symporter activity	1/922	144/18367	0.999416313623859	0.999999561785581	SLC16A3	1
GO:0015081	sodium ion transmembrane transporter activity	1/922	152/18367	0.999614739368205	0.999999561785581	SLC8A1	1
GO:0015103	inorganic anion transmembrane transporter activity	1/922	152/18367	0.999614739368205	0.999999561785581	CLIC1	1
GO:0015079	potassium ion transmembrane transporter activity	1/922	155/18367	0.999670333880367	0.999999561785581	KCNE3	1
GO:0022836	gated channel activity	5/922	340/18367	0.999878523104301	0.999999561785581	CYBB/KCNE3/HVCN1/PTK2B/CLIC1	5
GO:0005261	cation channel activity	4/922	335/18367	0.999968618307184	0.999999561785581	KCNE3/HVCN1/PTK2B/ATP6V1A	4
GO:0015267	channel activity	7/922	480/18367	0.999992969692787	0.999999561785581	CYBB/KCNE3/HVCN1/AQP9/PTK2B/CLIC1/ATP6V1A	7
GO:0022803	passive transmembrane transporter activity	7/922	481/18367	0.999993249415924	0.999999561785581	CYBB/KCNE3/HVCN1/AQP9/PTK2B/CLIC1/ATP6V1A	7
GO:0005216	ion channel activity	5/922	432/18367	0.999997570278964	0.999999561785581	KCNE3/HVCN1/PTK2B/CLIC1/ATP6V1A	5
GO:0046873	metal ion transmembrane transporter activity	4/922	430/18367	0.999999561785581	0.999999561785581	SLC11A1/SLC8A1/KCNE3/SLC31A2	4