ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	45/781	332/18367	5.58652418802539e-12	4.95524695477852e-09	ANXA1/COBLL1/S100P/EPS8L1/EGFR/EIF4G2/SLC3A2/BZW2/EZR/PPFIBP1/EIF5/KRT18/ERC1/GOLGA2/JUP/HSPA5/MB21D2/PHLDB2/RAB1A/HDLBP/SNX9/CD46/CHMP2B/SCYL1/DDX3X/CTNNB1/UBAP2/GIGYF2/BSG/PDXDC1/STX5/SLK/PPP1R13L/EIF4H/DNAJB1/LRRC59/CHMP4B/PRDX6/ARHGAP18/MPP7/SH3GLB2/USP8/HSPA8/PSMB6/CAST	45
GO:0051082	unfolded protein binding	19/781	122/18367	9.35600933767231e-07	0.000414939014125767	DNAJB4/ERN1/HSPA5/ERLEC1/DNAJA2/SIL1/PPIB/HSPA1B/CALR/CLPX/DNAJB1/DNAJB6/HSP90AA1/DNAJA1/RP2/HSPA8/ST13/HSPE1/HSPD1	19
GO:0051087	chaperone binding	17/781	107/18367	2.61657488527953e-06	0.000773633974414314	HES1/DNAJB4/DNAJB9/HSPA5/BAG1/FNIP1/DNAJA2/CALR/DNAJB1/DNAJB6/DNAJA1/TBCA/HSPA8/ST13/SOD1/HSPE1/HSPD1	17
GO:0019003	GDP binding	13/781	75/18367	1.48421106306442e-05	0.00329123803234535	RAB9A/ARL8B/GNAI1/RRAGC/RAB2A/RAP1B/RAB21/RAB5B/ARF1/RAB5A/RAB7A/RAP2C/RHEB	13
GO:0030674	protein-macromolecule adaptor activity	29/781	296/18367	2.6954129493715e-05	0.00354508579752773	DAB2/CDYL/SPAG9/EPB41L3/HERPUD1/AP2A1/JUP/GRIP1/DEDD2/NAPA/DLG5/SYNE2/SKP1/DDB1/APPBP2/STX5/SLC9A1/SNAP23/CUX1/PPP4R2/SORBS1/GOSR1/MPP7/PDCD6/PSMC6/GAS2L3/HSPA8/ST13/AP2M1	29
GO:0031625	ubiquitin protein ligase binding	29/781	297/18367	2.86921865472922e-05	0.00354508579752773	SQSTM1/UBE2B/EGFR/MAP1LC3B/GABARAPL1/BCL2/UBE2A/MAP1LC3A/NFKBIA/VCP/HSPA5/SLC25A5/ERBB3/BAG1/UBC/SNX9/MDM2/TANK/PSMD1/HSPA1B/TSG101/CALR/GABARAPL2/HSP90AA1/PRDX6/UBXN1/DNAJA1/HSPA8/HSPD1	29
GO:0090482	vitamin transmembrane transporter activity	8/781	31/18367	3.40326945409863e-05	0.00354508579752773	SLC2A1/SLC52A1/SLC19A2/SLC19A3/SLC19A1/SLC5A6/SLC52A3/SLC2A8	8
GO:0044389	ubiquitin-like protein ligase binding	30/781	316/18367	3.57638712715514e-05	0.00354508579752773	SQSTM1/UBE2B/EGFR/CEBPB/MAP1LC3B/GABARAPL1/BCL2/UBE2A/MAP1LC3A/NFKBIA/VCP/HSPA5/SLC25A5/ERBB3/BAG1/UBC/SNX9/MDM2/TANK/PSMD1/HSPA1B/TSG101/CALR/GABARAPL2/HSP90AA1/PRDX6/UBXN1/DNAJA1/HSPA8/HSPD1	30
GO:0003925	G protein activity	9/781	40/18367	3.61958094432967e-05	0.00354508579752773	RAB11A/ARL8B/RAP1B/RAB1A/RAB5B/RAB4B/RAB5A/RAB7A/RAP2C	9
GO:0042625	ATPase-coupled ion transmembrane transporter activity	6/781	17/18367	4.796057448741e-05	0.00354508579752773	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ATP6V0E1/ATP6V1C1	6
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	6/781	17/18367	4.796057448741e-05	0.00354508579752773	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ATP6V0E1/ATP6V1C1	6
GO:0046961	proton-transporting ATPase activity, rotational mechanism	6/781	17/18367	4.796057448741e-05	0.00354508579752773	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ATP6V0E1/ATP6V1C1	6
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	6/781	20/18367	0.000134625212983189	0.00918558183969912	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ATP6V0E1/ATP6V1C1	6
GO:0005525	GTP binding	32/781	377/18367	0.000168536986936589	0.0101590310252848	RHOBTB1/RAB11A/ARL4A/RAB9A/GNA12/AK3/TGM2/ANXA6/ARL8B/EIF5/GNAI1/GNAS/RRAGC/RAB2A/EHD3/RAP1B/ARF4/RAB1A/SAR1A/RAB21/RAB5B/ARF1/SAR1B/RAB4B/GNL1/RAB5A/RAB7A/EIF2B2/RAP2C/RHOBTB3/RP2/RHEB	32
GO:0008509	anion transmembrane transporter activity	28/781	314/18367	0.000188122430076927	0.0101590310252848	SLC26A2/SLC13A4/SLC22A11/SLC2A1/FXYD3/CLIC3/SLC52A1/SLC19A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC6A8/GABRE/SLC19A1/SLC7A5/SLC5A6/SLC52A3/CLCN3/SLC25A5/SLC4A2/SLC12A4/SLC16A3/SLC9A1/SLC2A8/SLC35B4/SLC13A3/CLDN4	28
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	27/781	299/18367	0.000198513411245091	0.0101590310252848	TBX3/TACC2/HSPB1/CEBPB/GABARAPL1/NCOA3/HES1/NFKBIA/HDAC5/MED13/JUND/TEAD3/ID2/GRIP1/CEBPA/BHLHE40/PPARD/GTF2B/CTNNB1/ANXA4/LCOR/CALR/TACC1/DNAJA1/COMMD7/ACTN4/NFE2L2	27
GO:0019001	guanyl nucleotide binding	33/781	398/18367	0.000207213834516093	0.0101590310252848	RHOBTB1/RAB11A/ARL4A/RAB9A/GNA12/AK3/TGM2/ANXA6/SLC19A1/ARL8B/EIF5/GNAI1/GNAS/RRAGC/RAB2A/EHD3/RAP1B/ARF4/RAB1A/SAR1A/RAB21/RAB5B/ARF1/SAR1B/RAB4B/GNL1/RAB5A/RAB7A/EIF2B2/RAP2C/RHOBTB3/RP2/RHEB	33
GO:0032561	guanyl ribonucleotide binding	33/781	398/18367	0.000207213834516093	0.0101590310252848	RHOBTB1/RAB11A/ARL4A/RAB9A/GNA12/AK3/TGM2/ANXA6/SLC19A1/ARL8B/EIF5/GNAI1/GNAS/RRAGC/RAB2A/EHD3/RAP1B/ARF4/RAB1A/SAR1A/RAB21/RAB5B/ARF1/SAR1B/RAB4B/GNL1/RAB5A/RAB7A/EIF2B2/RAP2C/RHOBTB3/RP2/RHEB	33
GO:0008135	translation factor activity, RNA binding	12/781	84/18367	0.000217611713055705	0.0101590310252848	EIF4G2/EIF1/ETF1/CPEB4/EIF5/EIF2S2/ABCF1/EIF2B2/EIF4H/AGO2/EIF4A1/EIF3J	12
GO:0060090	molecular adaptor activity	31/781	369/18367	0.000253894497452724	0.0106869121309233	DAB2/CDYL/SPAG9/EPB41L3/HERPUD1/AKAP9/AP2A1/JUP/PDE4DIP/GRIP1/DEDD2/NAPA/DLG5/SYNE2/SKP1/DDB1/APPBP2/STX5/SLC9A1/SNAP23/CUX1/PPP4R2/SORBS1/GOSR1/MPP7/PDCD6/PSMC6/GAS2L3/HSPA8/ST13/AP2M1	31
GO:0004674	protein serine/threonine kinase activity	32/781	386/18367	0.000257831211001536	0.0106869121309233	SQSTM1/PRKCZ/SGK1/EGFR/TOP1/MAST4/PIM3/TLK1/AAK1/BRAF/EIF2AK1/ERN1/NEK7/SIK3/LIMK2/LATS2/PDPK1/BRD2/CDK2/CSNK1A1/RPS6KA5/SLK/TBK1/BRD4/MAP3K13/CSNK1E/NRK/MAP3K4/TGFBR3/CDKL5/TAOK1/CCND3	32
GO:0003743	translation initiation factor activity	9/781	51/18367	0.000265064336956384	0.0106869121309233	EIF4G2/EIF1/EIF5/EIF2S2/EIF2B2/EIF4H/AGO2/EIF4A1/EIF3J	9
GO:0008514	organic anion transmembrane transporter activity	19/781	185/18367	0.000350341778988465	0.0135110068679464	SLC26A2/SLC22A11/SLC2A1/SLC52A1/SLC19A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC6A8/SLC19A1/SLC7A5/SLC5A6/SLC52A3/SLC25A5/SLC16A3/SLC2A8/SLC35B4/SLC13A3	19
GO:0016504	peptidase activator activity	8/781	43/18367	0.000398366323436012	0.0147229553703226	FBLN1/APP/VCP/PCOLCE2/ADRM1/TANK/CLPX/PSMD14	8
GO:0022853	active ion transmembrane transporter activity	24/781	267/18367	0.000469847904137156	0.0166702036387863	SLC26A2/SLC13A4/SLC22A11/SLC3A2/SLC38A1/SLC6A8/ATP6V1G1/SLC19A1/ATP6V1E1/SLC5A6/ATP6V1D/CLCN3/ATP6V0D1/SLC25A5/SLC4A2/SLC12A4/ATP6V0E1/ATP6V1C1/SLC9A1/COX4I1/SLC20A1/COX7B/COX6A1/SLC13A3	24
GO:0090079	translation regulator activity, nucleic acid binding	13/781	108/18367	0.000666831981181787	0.0226039249510576	EIF4G2/EIF1/ETF1/CPEB4/EIF5/PAIP2/EIF2S2/ABCF1/EIF2B2/EIF4H/AGO2/EIF4A1/EIF3J	13
GO:0097718	disordered domain specific binding	7/781	36/18367	0.000693937507247134	0.0226039249510576	EZR/NCOA3/MDM2/NUMA1/CTNNB1/HSP90AA1/AP2M1	7
GO:0015631	tubulin binding	30/781	375/18367	0.000713539908263374	0.0226039249510576	CLIP1/MAP1LC3B/GABARAPL1/RAB11A/EZR/ARL8B/MAP1LC3A/SBDS/FHDC1/GOLGA2/FMN1/HOOK3/CCSAP/DIP2B/MTUS1/CAPN6/NUMA1/DDX3X/HOOK2/RABGAP1/CAMSAP2/GABARAPL2/BEX4/KIF21A/PAFAH1B1/EML4/TBCA/GAS2L3/TAOK1/KATNBL1	30
GO:0140297	DNA-binding transcription factor binding	31/781	394/18367	0.000771990153497527	0.0227923714656496	TBX3/TACC2/HSPB1/CEBPB/GABARAPL1/NFYB/NCOA3/HES1/BCL2/DDIT3/NFKBIA/HDAC5/MED13/JUND/TEAD3/ID2/GRIP1/CEBPA/BHLHE40/PPARD/FOXO4/GTF2B/CTNNB1/ANXA4/LCOR/CALR/TACC1/DNAJA1/COMMD7/ACTN4/NFE2L2	31
GO:0001671	ATPase activator activity	6/781	27/18367	0.000797148357229575	0.0227923714656496	DNAJB4/DNAJA2/DNAJB1/DNAJB6/TOR1AIP2/DNAJA1	6
GO:0005543	phospholipid binding	35/781	466/18367	0.000841813685921196	0.0227923714656496	ANXA1/PIK3C2A/PHLDA2/SCIN/ANXA6/MME/MAP1LC3A/PXDC1/MTSS1/ATG2A/DYSF/SNX27/MYO10/OPHN1/EEA1/PITPNA/SYT7/ABCG1/GRB7/SH3YL1/GLTP/SNX9/NUMA1/TOM1/ZFYVE16/ANXA4/SNX6/SLC9A1/OSBP/COMMD1/HSPA8/CHMP2A/MYOF/FERMT2/IQGAP2	35
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	4/781	11/18367	0.000842429197370288	0.0227923714656496	GLDN/DSP/CD200/JUP	4
GO:0061134	peptidase regulator activity	21/781	230/18367	0.000847968724201168	0.0227923714656496	SERPINB2/FBLN1/SPINT1/APP/SERPINE1/CRIM1/VCP/PCOLCE2/FURIN/ITIH5/SERPINB9/SPINT2/ADRM1/APLP2/TANK/CLPX/GPC3/SERPINF1/PSMD14/TNFAIP8/CAST	21
GO:0030276	clathrin binding	10/781	72/18367	0.000898857945993825	0.0233006101550715	DAB2/PIK3C2A/CLTA/AP2A1/SYT7/TOM1/LDLR/LRP1/CLTB/AP2M1	10
GO:0045182	translation regulator activity	15/781	140/18367	0.000919415282330895	0.0233006101550715	EIF4G2/EIF1/ETF1/EIF2AK1/CPEB4/EIF5/PAIP2/EIF2S2/EIF4A3/ABCF1/EIF2B2/EIF4H/AGO2/EIF4A1/EIF3J	15
GO:0003712	transcription coregulator activity	36/781	489/18367	0.00102111181002274	0.0251590604302824	ARID5B/NUPR1/BASP1/SIN3B/TFAP2A/NCOA3/CDYL/RYBP/SIAH2/TCF25/ARID3A/SAP18/MED13/BCL9L/BTG1/JUP/EDF1/KMT2C/VGLL1/JMY/AKIRIN1/TRIP11/KDM5B/CTNNB1/AKIRIN2/LCOR/TSG101/PPP1R13L/BRD4/DNAJB1/TACC1/SRA1/RAP2C/SUB1/USP16/ACTN4	36
GO:0022804	active transmembrane transporter activity	31/781	406/18367	0.00125414368494659	0.0290969075941618	SLC26A2/SLC13A4/SLC22A11/SLC3A2/SLC38A1/SLC6A8/ATP6V1G1/SLC19A1/NDUFA6/ATP6V1E1/SLC7A5/SLC5A6/SLC25A16/ATP6V1D/CLCN3/ATP6V0D1/SLC25A5/ABCG1/SLC7A6/SLC4A2/SLC12A4/ATP6V0E1/SLC16A3/ATP6V1C1/SLC9A1/COX4I1/SLC20A1/COX7B/COX6A1/SLC13A3/NDUFB9	31
GO:0003924	GTPase activity	27/781	337/18367	0.00126131620798218	0.0290969075941618	RHOBTB1/RAB11A/ARL4A/RASA1/RAB9A/GNA12/ARL8B/GNAI1/GNAS/RRAGC/RAB2A/RAP1B/ARF4/RAB1A/SAR1A/RAB21/RAB5B/ARF1/DDX3X/SAR1B/RAB4B/GNL1/RAB5A/RAB7A/RAP2C/RHOBTB3/RHEB	27
GO:0015078	proton transmembrane transporter activity	14/781	130/18367	0.00127934542973203	0.0290969075941618	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0A1/CLCN3/ATP6V0D1/SLC25A5/ATP6V0B/ATP6V0E1/ATP6V1C1/SLC9A1/COX4I1/COX7B/COX6A1	14
GO:0044183	protein folding chaperone	7/781	40/18367	0.00133739434628416	0.0296567196288512	HSPB1/HSPA5/HSPA1B/CALR/DNAJB1/DNAJB6/HSPA8	7
GO:0051020	GTPase binding	24/781	291/18367	0.00155930066512222	0.0337341387795954	RASA1/GOLGA4/CLTA/SH3BP4/RRAGC/FGD6/ERC1/DVL3/TBC1D20/CDC42EP4/DIAPH2/TRIP11/YIPF2/GOLGA5/RABGAP1/CCDC186/HSP90AA1/TNPO1/RAB11FIP1/ERRFI1/CDKL5/RHOBTB3/SOD1/IQGAP2	24
GO:0043130	ubiquitin binding	11/781	92/18367	0.00178579621194393	0.0377143152379586	SQSTM1/HSPB1/OTUB2/UBE2A/UBR5/MDM2/ADRM1/TOM1/TSG101/UBXN1/USP16	11
GO:0072349	modified amino acid transmembrane transporter activity	5/781	22/18367	0.00197596291682181	0.0407599792376965	SLC19A2/SLC6A8/SLC19A1/SLC5A6/SLC13A3	5
GO:0004298	threonine-type endopeptidase activity	4/781	14/18367	0.00230737113765288	0.0465145045249569	PSMB1/PSMB4/PSMB5/PSMB6	4
GO:0008017	microtubule binding	22/781	271/18367	0.002908626999253	0.0558638308345342	CLIP1/MAP1LC3B/RAB11A/EZR/MAP1LC3A/SBDS/FHDC1/GOLGA2/FMN1/HOOK3/CCSAP/MTUS1/CAPN6/NUMA1/HOOK2/CAMSAP2/GABARAPL2/KIF21A/PAFAH1B1/EML4/GAS2L3/KATNBL1	22
GO:0035091	phosphatidylinositol binding	22/781	271/18367	0.002908626999253	0.0558638308345342	PIK3C2A/PHLDA2/SCIN/PXDC1/ATG2A/SNX27/MYO10/EEA1/PITPNA/SYT7/GRB7/SH3YL1/SNX9/NUMA1/TOM1/ZFYVE16/SNX6/SLC9A1/OSBP/COMMD1/FERMT2/IQGAP2	22
GO:0004867	serine-type endopeptidase inhibitor activity	11/781	98/18367	0.00296009024715119	0.0558638308345342	SERPINB2/SPINT1/APP/SERPINE1/CRIM1/FURIN/ITIH5/SERPINB9/SPINT2/APLP2/SERPINF1	11
GO:0005545	1-phosphatidylinositol binding	4/781	15/18367	0.00304146794996949	0.0562037931588112	SCIN/EEA1/SNX9/ZFYVE16	4
GO:0008013	beta-catenin binding	10/781	85/18367	0.0032018721645475	0.0579604206112986	DACT2/GLI3/BCL9L/GRIP1/DVL3/FOXO4/DLG5/SKP1/CTNNB1/KANK1	10
GO:0098632	cell-cell adhesion mediator activity	7/781	49/18367	0.00442963860996602	0.0777900660981083	ANXA1/GLDN/DSP/CD200/KRT18/JUP/BSG	7
GO:0051117	ATPase binding	10/781	89/18367	0.00447270955017308	0.0777900660981083	EGFR/EZR/ATP6V1G1/ATP6V1E1/ATP6V0A1/DNAJB1/GABARAPL2/TOR1AIP2/UBXN1/TMEM106B	10
GO:0070064	proline-rich region binding	4/781	17/18367	0.00495600682014779	0.083681507833068	GHR/GIGYF2/GAREM1/RABAC1	4
GO:0015175	neutral amino acid transmembrane transporter activity	6/781	38/18367	0.00500013519182932	0.083681507833068	SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5	6
GO:0070325	lipoprotein particle receptor binding	5/781	28/18367	0.00597434849607179	0.0981342058521421	LRPAP1/AP2A1/LRP1/DNAJA1/AP2M1	5
GO:0106310	protein serine kinase activity	26/781	360/18367	0.00616768784622299	0.0994679839927236	PRKCZ/SGK1/MAST4/PIM3/TLK1/AAK1/BRAF/EIF2AK1/ERN1/NEK7/STK40/SIK3/LIMK2/LATS2/PDPK1/CDK2/CSNK1A1/RPS6KA5/SLK/TBK1/MAP3K13/CSNK1E/NRK/MAP3K4/CDKL5/TAOK1	26
GO:0033218	amide binding	28/781	400/18367	0.00696795382941729	0.107887246924544	SLC40A1/MAP1LC3B/SLC19A1/MME/CLTA/KPNA6/SLC7A5/NFKBIA/GHR/LRPAP1/FURIN/FKBP2/KDELR2/MTHFS/GLTP/CLN8/ACADVL/LDLR/PPIB/LRP1/CALR/PRLR/ACBD3/KDELR1/ENPEP/TNPO1/CLTB/AP2M1	28
GO:0051787	misfolded protein binding	5/781	29/18367	0.00697111794952974	0.107887246924544	DNAJB9/HSPA5/EDEM1/HSPA1B/HSPA8	5
GO:0015291	secondary active transmembrane transporter activity	19/781	240/18367	0.00705463395898935	0.107887246924544	SLC26A2/SLC13A4/SLC22A11/SLC3A2/SLC38A1/SLC6A8/SLC19A1/SLC7A5/SLC5A6/SLC25A16/CLCN3/SLC25A5/SLC7A6/SLC4A2/SLC12A4/SLC16A3/SLC9A1/SLC20A1/SLC13A3	19
GO:0048487	beta-tubulin binding	6/781	41/18367	0.007314050046901	0.107993300608363	GABARAPL1/ARL8B/GABARAPL2/EML4/TBCA/TAOK1	6
GO:0015924	mannosyl-oligosaccharide mannosidase activity	3/781	10/18367	0.00734357006808779	0.107993300608363	MAN1A2/EDEM1/MAN1C1	3
GO:0031267	small GTPase binding	20/781	259/18367	0.00758006918668164	0.107993300608363	GOLGA4/SH3BP4/FGD6/ERC1/DVL3/TBC1D20/CDC42EP4/DIAPH2/TRIP11/YIPF2/GOLGA5/RABGAP1/CCDC186/TNPO1/RAB11FIP1/ERRFI1/CDKL5/RHOBTB3/SOD1/IQGAP2	20
GO:0032182	ubiquitin-like protein binding	11/781	111/18367	0.00762501265637493	0.107993300608363	SQSTM1/HSPB1/OTUB2/UBE2A/UBR5/MDM2/ADRM1/TOM1/TSG101/UBXN1/USP16	11
GO:0003779	actin binding	30/781	440/18367	0.00767032462043612	0.107993300608363	COBLL1/RAI14/PDLIM2/EPS8L1/EGFR/SCIN/EZR/ANXA6/EPB41L3/FHDC1/MTSS1/SPIRE2/MYO10/FMN1/WASL/OPHN1/P4HB/TPM4/JMY/SYNE2/NEBL/DIAPH2/CAP2/MYO6/UTRN/SORBS1/ACTN4/GAS2L3/FERMT2/IQGAP2	30
GO:0003713	transcription coactivator activity	20/781	262/18367	0.00855814489656525	0.118610539425834	ARID5B/NUPR1/NCOA3/MED13/BCL9L/JUP/EDF1/KMT2C/VGLL1/JMY/TRIP11/CTNNB1/TSG101/BRD4/TACC1/SRA1/RAP2C/SUB1/USP16/ACTN4	20
GO:0031072	heat shock protein binding	12/781	129/18367	0.00892843165381761	0.121838751952865	ERN1/DNAJB9/HSPA5/BAG1/LMAN2/DNAJA2/HSPA1B/DNAJB1/DNAJB6/DNAJA1/HSPA8/ST13	12
GO:0030544	Hsp70 protein binding	6/781	43/18367	0.00923281347545504	0.124083417465585	ERN1/DNAJB9/DNAJA2/DNAJB1/DNAJA1/ST13	6
GO:0043021	ribonucleoprotein complex binding	13/781	149/18367	0.011142883734413	0.147518475707826	SECISBP2L/EIF1/ETF1/CPEB4/SBDS/HSPA5/NEAT1/MDM2/DDX3X/RICTOR/EIF4A3/EIF4H/RPN2	13
GO:0019903	protein phosphatase binding	13/781	150/18367	0.011742238972379	0.150947332876814	EGFR/KCNN4/BCL2/GHR/VCP/JUP/MVP/IRS2/CTNNB1/SLC9A1/TBK1/STAU1/SOD1	13
GO:0140677	molecular function activator activity	13/781	150/18367	0.011742238972379	0.150947332876814	NUPR1/GNAS/DNAJB4/PPP1R12B/PDPK1/ARF1/DNAJA2/DNAJB1/DNAJB6/AZIN1/TOR1AIP2/DNAJA1/DDOST	13
GO:0098631	cell adhesion mediator activity	7/781	59/18367	0.0122242573979225	0.154898804456532	ANXA1/GLDN/DSP/CD200/KRT18/JUP/BSG	7
GO:0048306	calcium-dependent protein binding	9/781	88/18367	0.0124017803172179	0.154934917484117	ANXA1/S100P/ANXA6/CLN3/ANXA4/TSG101/SLC9A1/PDCD6/SEC31A	9
GO:0034452	dynactin binding	3/781	12/18367	0.0126348964120766	0.155654904409888	HOOK3/SNX6/PAFAH1B1	3
GO:0003725	double-stranded RNA binding	8/781	74/18367	0.013099696528348	0.15917028521431	TFRC/SLC3A2/DHX36/EIF4H/AGO2/EIF4A1/STAU1/HSPD1	8
GO:0015297	antiporter activity	9/781	89/18367	0.0132938007785104	0.159345963385658	SLC26A2/SLC3A2/SLC19A1/SLC25A16/CLCN3/SLC25A5/SLC7A6/SLC4A2/SLC9A1	9
GO:0019829	ATPase-coupled cation transmembrane transporter activity	6/781	47/18367	0.0141018670336179	0.166778080784255	ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ATP6V0E1/ATP6V1C1	6
GO:0015179	L-amino acid transmembrane transporter activity	7/781	61/18367	0.0145402990507592	0.169700595500308	SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5/SLC7A6	7
GO:0050750	low-density lipoprotein particle receptor binding	4/781	23/18367	0.0150705315072767	0.170987552285942	LRPAP1/AP2A1/DNAJA1/AP2M1	4
GO:0008022	protein C-terminus binding	15/781	189/18367	0.0152185256413857	0.170987552285942	DAB2/SIAH1/PRRC2C/EZR/FBLN1/SDC1/AP2A1/GRIP1/TAF13/NUMA1/CTNNB1/VPS4B/SYNJ1/AGO2/RABAC1	15
GO:0001618	virus receptor activity	8/781	76/18367	0.0152288800795822	0.170987552285942	TFRC/EGFR/SLC52A1/CD55/CD46/BSG/LDLR/HSPA1B	8
GO:0120013	lipid transfer activity	6/781	48/18367	0.0155538148878285	0.172452922568799	GRAMD1C/PITPNA/ABCG1/GLTP/PRELID1/OSBP	6
GO:0052650	NADP-retinol dehydrogenase activity	3/781	13/18367	0.0159138407264258	0.174266379312835	AKR1B1/RDH13/RDH10	3
GO:0140272	exogenous protein binding	8/781	77/18367	0.0163826836944807	0.177212688256151	TFRC/EGFR/SLC52A1/CD55/CD46/BSG/LDLR/HSPA1B	8
GO:0016853	isomerase activity	13/781	158/18367	0.0174783220750026	0.181401574906407	TOP1/CYP2J2/BPGM/ISYNA1/P4HB/FKBP2/GLCE/IDI1/DDT/PPIB/PDIA3/MIF/HSPD1	13
GO:0043495	protein-membrane adaptor activity	4/781	24/18367	0.0174901129103781	0.181401574906407	EPB41L3/JUP/SYNE2/PDCD6	4
GO:0070003	threonine-type peptidase activity	4/781	24/18367	0.0174901129103781	0.181401574906407	PSMB1/PSMB4/PSMB5/PSMB6	4
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	29/781	450/18367	0.0175879768229436	0.181401574906407	TBX3/MAFF/ESRRG/ZNF292/CEBPB/GATA3/NFYB/TFAP2A/ATF3/DDIT3/EPAS1/GRHL1/GCM1/ELF3/MAFG/CREB3L2/ZFAT/JUND/GATA2/CEBPA/ZNF91/CREBRF/ZNF750/FOXO4/IRF6/ATF1/DLX5/PBX1/NFE2L2	29
GO:0000149	SNARE binding	10/781	110/18367	0.0187387900638334	0.187173176484321	RAB11A/GOLGA2/SYT7/NAPA/UVRAG/TMED9/STX5/STXBP3/SNAP23/GABARAPL2	10
GO:0005048	signal sequence binding	6/781	50/18367	0.0187614900204281	0.187173176484321	KPNA6/NFKBIA/KDELR2/KDELR1/TNPO1/AP2M1	6
GO:0061135	endopeptidase regulator activity	15/781	194/18367	0.0188553199988736	0.187173176484321	SERPINB2/SPINT1/APP/SERPINE1/CRIM1/FURIN/ITIH5/SERPINB9/SPINT2/ADRM1/APLP2/SERPINF1/PSMD14/TNFAIP8/CAST	15
GO:0042826	histone deacetylase binding	11/781	127/18367	0.0195805171612487	0.187173176484321	CEBPB/HES1/GLI3/GCM1/HDAC5/DHX36/MAGEA10/HSPA1B/LCOR/BEX4/HSP90AA1	11
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	3/781	14/18367	0.0196246960688184	0.187173176484321	IDI1/DDT/MIF	3
GO:0035259	glucocorticoid receptor binding	3/781	14/18367	0.0196246960688184	0.187173176484321	CEBPB/GRIP1/TACC1	3
GO:0140666	annealing activity	3/781	14/18367	0.0196246960688184	0.187173176484321	ANXA1/DDX3X/EIF4H	3
GO:0016922	nuclear receptor binding	12/781	144/18367	0.0200005849332206	0.1880273322102	TACC2/CEBPB/NCOA3/MED13/JUND/GRIP1/GTF2B/CTNNB1/LCOR/CALR/TACC1/ACTN4	12
GO:0034237	protein kinase A regulatory subunit binding	4/781	25/18367	0.0201382148364927	0.1880273322102	EZR/AKAP9/GSKIP/ACBD3	4
GO:0001216	DNA-binding transcription activator activity	29/781	456/18367	0.0206077545709885	0.18865200378739	TBX3/MAFF/ESRRG/ZNF292/CEBPB/GATA3/NFYB/TFAP2A/ATF3/DDIT3/EPAS1/GRHL1/GCM1/ELF3/MAFG/CREB3L2/ZFAT/JUND/GATA2/CEBPA/ZNF91/CREBRF/ZNF750/FOXO4/IRF6/ATF1/DLX5/PBX1/NFE2L2	29
GO:0140678	molecular function inhibitor activity	11/781	128/18367	0.0206304897039197	0.18865200378739	ANXA1/RASA1/NEDD4L/BCL2/DDIT3/ID2/PPP1R12B/FNIP1/DYNLL1/ANXA4/COMMD1	11
GO:0046943	carboxylic acid transmembrane transporter activity	13/781	163/18367	0.0220099445118608	0.198630210879207	SLC26A2/SLC19A2/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC19A1/SLC7A5/SLC5A6/SLC7A6/SLC16A3/SLC13A3	13
GO:0031593	polyubiquitin modification-dependent protein binding	6/781	52/18367	0.0223934848792793	0.198630210879207	SQSTM1/VCP/ZFAND6/UBQLN1/UBXN1/PSMD4	6
GO:1901682	sulfur compound transmembrane transporter activity	6/781	52/18367	0.0223934848792793	0.198630210879207	SLC26A2/SLC13A4/SLC19A2/SLC19A3/SLC5A6/SLC13A3	6
GO:0005342	organic acid transmembrane transporter activity	13/781	164/18367	0.0230124820508823	0.201805474600104	SLC26A2/SLC19A2/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC19A1/SLC7A5/SLC5A6/SLC7A6/SLC16A3/SLC13A3	13
GO:0004559	alpha-mannosidase activity	3/781	15/18367	0.0237705030985306	0.201805474600104	MAN1A2/EDEM1/MAN1C1	3
GO:0005041	low-density lipoprotein particle receptor activity	3/781	15/18367	0.0237705030985306	0.201805474600104	OLR1/LDLR/LRP1	3
GO:0071933	Arp2/3 complex binding	3/781	15/18367	0.0237705030985306	0.201805474600104	JMY/SNX9/IQGAP2	3
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	5/781	39/18367	0.0238890358884002	0.201805474600104	MYO10/ZFYVE16/COMMD1/FERMT2/IQGAP2	5
GO:0004709	MAP kinase kinase kinase activity	4/781	27/18367	0.0261395498275282	0.215482009632292	EGFR/BRAF/MAP3K13/MAP3K4	4
GO:0017080	sodium channel regulator activity	5/781	40/18367	0.0263772999550212	0.215482009632292	SGK1/FXYD3/NEDD4L/PRSS8/COMMD1	5
GO:0043014	alpha-tubulin binding	5/781	40/18367	0.0263772999550212	0.215482009632292	ARL8B/DIP2B/BEX4/EML4/TAOK1	5
GO:0005496	steroid binding	9/781	100/18367	0.0264797509018262	0.215482009632292	HSD17B1/ESRRG/HSD11B2/PGRMC2/ANXA6/GRAMD1C/ABCG1/OSBP/INSIG1	9
GO:0000287	magnesium ion binding	16/781	221/18367	0.027064462925724	0.218237987410156	S100P/ATP10D/PAPOLA/MAST4/GNAI1/RRAGC/ERN1/DHX36/SIK3/ARF1/PI4K2A/PDXK/RPS6KA5/PDCD6/RP2/RHEB	16
GO:0005159	insulin-like growth factor receptor binding	3/781	16/18367	0.0283513334884376	0.22453243575218	INSL4/GNAS/SOCS1	3
GO:0015923	mannosidase activity	3/781	16/18367	0.0283513334884376	0.22453243575218	MAN1A2/EDEM1/MAN1C1	3
GO:0030414	peptidase inhibitor activity	14/781	187/18367	0.0289821658845083	0.226978301301434	SERPINB2/SPINT1/APP/SERPINE1/CRIM1/FURIN/ITIH5/SERPINB9/SPINT2/APLP2/GPC3/SERPINF1/TNFAIP8/CAST	14
GO:0002020	protease binding	11/781	135/18367	0.0291719575517063	0.226978301301434	SERPINE1/BCL2/VCP/FURIN/SERPINB9/DVL3/UBC/ADRM1/LDLR/LCOR/LRP1	11
GO:1990756	ubiquitin ligase-substrate adaptor activity	4/781	28/18367	0.0295004167161043	0.227537996758126	HERPUD1/SKP1/APPBP2/PDCD6	4
GO:0030374	nuclear receptor coactivator activity	6/781	56/18367	0.0310127420128516	0.237140535908615	NCOA3/MED13/TSG101/TACC1/SRA1/ACTN4	6
GO:0003727	single-stranded RNA binding	8/781	87/18367	0.0315776500243404	0.239396372406752	ANXA1/RBMS1/DDX3X/EIF4A3/EIF4H/AGO2/SRA1/MSI2	8
GO:0015301	anion:anion antiporter activity	4/781	29/18367	0.0331051045187563	0.246620133049843	SLC26A2/SLC19A1/SLC25A5/SLC4A2	4
GO:0051059	NF-kappaB binding	4/781	29/18367	0.0331051045187563	0.246620133049843	NFKBIA/PPARD/ANXA4/COMMD7	4
GO:0043024	ribosomal small subunit binding	3/781	17/18367	0.0333646177744996	0.246620133049843	EIF1/DDX3X/EIF4H	3
GO:0046966	thyroid hormone receptor binding	4/781	30/18367	0.0369553602981986	0.270904170119852	NCOA3/MED13/GTF2B/TACC1	4
GO:0019905	syntaxin binding	7/781	74/18367	0.0375713787559065	0.273162401282697	RAB11A/GOLGA2/SYT7/NAPA/TMED9/STXBP3/SNAP23	7
GO:0030228	lipoprotein particle receptor activity	3/781	18/18367	0.0388054473297026	0.277584127269727	OLR1/LDLR/LRP1	3
GO:0033549	MAP kinase phosphatase activity	3/781	18/18367	0.0388054473297026	0.277584127269727	DUSP5/DUSP9/DUSP3	3
GO:0019902	phosphatase binding	14/781	196/18367	0.0406745691803881	0.288626742904034	EGFR/KCNN4/BCL2/GHR/VCP/JUP/SH3YL1/MVP/IRS2/CTNNB1/SLC9A1/TBK1/STAU1/SOD1	14
GO:0005178	integrin binding	11/781	144/18367	0.0435343298069672	0.306467861418888	EGFR/FBLN1/PLPP3/SEMA7A/P4HB/ITGB4/LGALS8/CALR/UTRN/ACTN4/FERMT2	11
GO:0004866	endopeptidase inhibitor activity	13/781	180/18367	0.0440025181947763	0.307127890769868	SERPINB2/SPINT1/APP/SERPINE1/CRIM1/FURIN/ITIH5/SERPINB9/SPINT2/APLP2/SERPINF1/TNFAIP8/CAST	13
GO:0004129	cytochrome-c oxidase activity	3/781	19/18367	0.044666852208921	0.307127890769868	COX4I1/COX7B/COX6A1	3
GO:0035615	clathrin adaptor activity	3/781	19/18367	0.044666852208921	0.307127890769868	DAB2/AP2A1/AP2M1	3
GO:0015399	primary active transmembrane transporter activity	13/781	181/18367	0.045651101924544	0.311480980054388	SLC26A2/ATP6V1G1/NDUFA6/ATP6V1E1/ATP6V1D/ATP6V0D1/ABCG1/ATP6V0E1/ATP6V1C1/COX4I1/COX7B/COX6A1/NDUFB9	13
GO:0001221	transcription coregulator binding	7/781	78/18367	0.0478186710571693	0.32377985670007	EPAS1/MAFK/PPARD/CTNNB1/LCOR/UBE2I/NFE2L2	7
GO:0140323	solute:anion antiporter activity	4/781	33/18367	0.0499854113822209	0.331941325652249	SLC26A2/SLC19A1/SLC25A5/SLC4A2	4
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/781	20/18367	0.0509400565037616	0.331941325652249	COX4I1/COX7B/COX6A1	3
GO:0031683	G-protein beta/gamma-subunit complex binding	3/781	20/18367	0.0509400565037616	0.331941325652249	GNA12/GNAI1/GNAS	3
GO:0097001	ceramide binding	3/781	20/18367	0.0509400565037616	0.331941325652249	MAP1LC3B/GLTP/CLN8	3
GO:0140312	cargo adaptor activity	3/781	20/18367	0.0509400565037616	0.331941325652249	DAB2/AP2A1/AP2M1	3
GO:0008201	heparin binding	12/781	166/18367	0.051269404300291	0.331941325652249	PGF/GREM2/APP/SMOC1/LRPAP1/PCOLCE2/ADGRG1/LAMC2/APLP2/NRP1/PAFAH1B1/TGFBR3	12
GO:0016248	channel inhibitor activity	4/781	34/18367	0.0548201613336306	0.349823619445542	RASA1/NEDD4L/BCL2/COMMD1	4
GO:0030291	protein serine/threonine kinase inhibitor activity	4/781	34/18367	0.0548201613336306	0.349823619445542	HSPB1/CDKN1C/HEXIM1/PKIB	4
GO:0003714	transcription corepressor activity	13/781	187/18367	0.0564489665878259	0.357644524024297	BASP1/SIN3B/TFAP2A/CDYL/RYBP/SIAH2/TCF25/SAP18/KDM5B/LCOR/TSG101/PPP1R13L/DNAJB1	13
GO:0042277	peptide binding	20/781	321/18367	0.0573064780939389	0.359889085950859	SLC40A1/MME/CLTA/KPNA6/SLC7A5/NFKBIA/GHR/LRPAP1/FURIN/KDELR2/LDLR/PPIB/LRP1/CALR/PRLR/KDELR1/ENPEP/TNPO1/CLTB/AP2M1	20
GO:0051010	microtubule plus-end binding	3/781	21/18367	0.0576147127452334	0.359889085950859	CLIP1/NUMA1/PAFAH1B1	3
GO:0042887	amide transmembrane transporter activity	4/781	35/18367	0.0598980511691578	0.361900039038549	SLC19A2/SLC19A1/SLC5A6/SLC13A3	4
GO:0030159	signaling receptor complex adaptor activity	5/781	50/18367	0.0603424723645581	0.361900039038549	SPAG9/GRIP1/DEDD2/DLG5/SORBS1	5
GO:0043022	ribosome binding	6/781	66/18367	0.0611534151335987	0.361900039038549	ETF1/CPEB4/SBDS/HSPA5/RICTOR/RPN2	6
GO:0016860	intramolecular oxidoreductase activity	5/781	51/18367	0.0646706683816721	0.361900039038549	P4HB/IDI1/DDT/PDIA3/MIF	5
GO:0051018	protein kinase A binding	5/781	51/18367	0.0646706683816721	0.361900039038549	EZR/DACT2/AKAP9/GSKIP/ACBD3	5
GO:0004602	glutathione peroxidase activity	3/781	22/18367	0.0646791167967511	0.361900039038549	GPX3/MGST3/PRDX6	3
GO:0005355	glucose transmembrane transporter activity	3/781	22/18367	0.0646791167967511	0.361900039038549	SLC2A1/SLC2A12/SLC2A8	3
GO:0008093	cytoskeletal anchor activity	3/781	22/18367	0.0646791167967511	0.361900039038549	EPB41L3/JUP/GAS2L3	3
GO:0008106	alcohol dehydrogenase (NADP+) activity	3/781	22/18367	0.0646791167967511	0.361900039038549	AKR1B1/RDH13/RDH10	3
GO:0015149	hexose transmembrane transporter activity	3/781	22/18367	0.0646791167967511	0.361900039038549	SLC2A1/SLC2A12/SLC2A8	3
GO:0008330	protein tyrosine/threonine phosphatase activity	2/781	10/18367	0.0647929168093078	0.361900039038549	DUSP5/DUSP9	2
GO:0015173	aromatic amino acid transmembrane transporter activity	2/781	10/18367	0.0647929168093078	0.361900039038549	SLC3A2/SLC7A5	2
GO:0030957	Tat protein binding	2/781	10/18367	0.0647929168093078	0.361900039038549	GABARAPL1/DNAJA1	2
GO:0034713	type I transforming growth factor beta receptor binding	2/781	10/18367	0.0647929168093078	0.361900039038549	SNX6/FERMT2	2
GO:0045294	alpha-catenin binding	2/781	10/18367	0.0647929168093078	0.361900039038549	JUP/CTNNB1	2
GO:0051880	G-quadruplex DNA binding	2/781	10/18367	0.0647929168093078	0.361900039038549	DHX36/XRN1	2
GO:0097110	scaffold protein binding	6/781	67/18367	0.0648727240215663	0.361900039038549	DSP/BRAF/KRT18/KRT8/DYNLL1/HSP90AA1	6
GO:1901981	phosphatidylinositol phosphate binding	12/781	173/18367	0.0658845415095607	0.364980006011228	PHLDA2/SCIN/ATG2A/SNX27/MYO10/SYT7/ZFYVE16/SLC9A1/OSBP/COMMD1/FERMT2/IQGAP2	12
GO:0015171	amino acid transmembrane transporter activity	7/781	84/18367	0.0662477801215419	0.364980006011228	SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5/SLC7A6	7
GO:0043531	ADP binding	4/781	37/18367	0.0707726997437055	0.387502374522635	ERN1/VCP/ABCG1/MYO6	4
GO:0005158	insulin receptor binding	3/781	23/18367	0.0721204045901722	0.38770181134232	PDPK1/IRS2/SORBS1	3
GO:0008143	poly(A) binding	3/781	23/18367	0.0721204045901722	0.38770181134232	RBMS1/DDX3X/EIF4A3	3
GO:0120015	sterol transfer activity	3/781	23/18367	0.0721204045901722	0.38770181134232	GRAMD1C/ABCG1/OSBP	3
GO:0016887	ATP hydrolysis activity	17/781	272/18367	0.0734563366283958	0.392504642104741	ATP10D/VCP/DDX28/DHX36/HSPA5/DDX3X/VPS4B/HSPA1B/EIF4A3/CLPX/KIF21A/CHD2/HSP90AA1/RHOBTB3/EIF4A1/HSPA8/HSPD1	17
GO:0004860	protein kinase inhibitor activity	6/781	70/18367	0.0768080456188016	0.392583271673324	HSPB1/CDKN1C/HEXIM1/SOCS1/PKIB/GSKIP	6
GO:0000774	adenyl-nucleotide exchange factor activity	2/781	11/18367	0.0770176765681303	0.392583271673324	BAG1/SIL1	2
GO:0019107	myristoyltransferase activity	2/781	11/18367	0.0770176765681303	0.392583271673324	ZDHHC3/ZDHHC20	2
GO:0043522	leucine zipper domain binding	2/781	11/18367	0.0770176765681303	0.392583271673324	DDIT3/ERC1	2
GO:1901474	azole transmembrane transporter activity	2/781	11/18367	0.0770176765681303	0.392583271673324	SLC19A2/SLC19A3	2
GO:1990226	histone methyltransferase binding	2/781	11/18367	0.0770176765681303	0.392583271673324	CTNNB1/LCOR	2
GO:0005544	calcium-dependent phospholipid binding	5/781	54/18367	0.0786671492967987	0.392583271673324	ANXA1/ANXA6/DYSF/SYT7/ANXA4	5
GO:0015459	potassium channel regulator activity	5/781	54/18367	0.0786671492967987	0.392583271673324	PRKCZ/SGK1/RASA1/NEDD4L/AKAP9	5
GO:0140030	modification-dependent protein binding	11/781	160/18367	0.0797515067707174	0.392583271673324	SQSTM1/CDYL/VCP/BRD2/ZFAND6/BRD4/UBQLN1/MORC4/UBXN1/PSMD4/HSPD1	11
GO:0003707	steroid hormone receptor activity	3/781	24/18367	0.0799247319729999	0.392583271673324	ESRRG/PGRMC2/PPARD	3
GO:0015145	monosaccharide transmembrane transporter activity	3/781	24/18367	0.0799247319729999	0.392583271673324	SLC2A1/SLC2A12/SLC2A8	3
GO:0043274	phospholipase binding	3/781	24/18367	0.0799247319729999	0.392583271673324	PRKCZ/PDPK1/PAFAH1B1	3
GO:0070840	dynein complex binding	3/781	24/18367	0.0799247319729999	0.392583271673324	DCTN6/NUMA1/PAFAH1B1	3
GO:0120014	phospholipid transfer activity	3/781	24/18367	0.0799247319729999	0.392583271673324	PITPNA/GLTP/PRELID1	3
GO:0051015	actin filament binding	14/781	217/18367	0.0801100024496861	0.392583271673324	EGFR/SCIN/EZR/ANXA6/MYO10/TPM4/SYNE2/NEBL/MYO6/UTRN/ACTN4/GAS2L3/FERMT2/IQGAP2	14
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/781	39/18367	0.0825826057893386	0.402476765577711	UBE2B/UBE2A/UBE2H/UBE2I	4
GO:0005080	protein kinase C binding	5/781	55/18367	0.0836655884789897	0.405526650168655	SQSTM1/HSPB1/DSP/DACT2/HDAC5	5
GO:0005160	transforming growth factor beta receptor binding	3/781	25/18367	0.0880774388552509	0.42191077100323	SNX6/TGFBR3/FERMT2	3
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	2/781	12/18367	0.089894232599341	0.42191077100323	CDKN1C/HEXIM1	2
GO:0031543	peptidyl-proline dioxygenase activity	2/781	12/18367	0.089894232599341	0.42191077100323	P4HB/EGLN2	2
GO:0042975	peroxisome proliferator activated receptor binding	2/781	12/18367	0.089894232599341	0.42191077100323	MDM2/TACC1	2
GO:0015370	solute:sodium symporter activity	6/781	73/18367	0.0898998147909927	0.42191077100323	SLC13A4/SLC38A1/SLC6A8/SLC5A6/SLC20A1/SLC13A3	6
GO:0070063	RNA polymerase binding	6/781	73/18367	0.0898998147909927	0.42191077100323	NCOA3/GTF2B/PPIB/BRD4/AGO2/STOM	6
GO:0042626	ATPase-coupled transmembrane transporter activity	8/781	109/18367	0.0929217083058955	0.433797659301733	SLC26A2/ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0D1/ABCG1/ATP6V0E1/ATP6V1C1	8
GO:0019210	kinase inhibitor activity	6/781	74/18367	0.0945170297352651	0.438935106676336	HSPB1/CDKN1C/HEXIM1/SOCS1/PKIB/GSKIP	6
GO:0008198	ferrous iron binding	3/781	26/18367	0.096563198769528	0.446101860982142	TET2/EGLN2/CDO1	3
GO:0072341	modified amino acid binding	7/781	93/18367	0.100904926571353	0.453688249441823	SCIN/ANXA6/SLC19A1/MME/SYT7/MTHFS/HSPA8	7
GO:1901681	sulfur compound binding	16/781	265/18367	0.101280224583282	0.453688249441823	PGF/GREM2/APP/ANXA6/SMOC1/LRPAP1/PCOLCE2/ADGRG1/LAMC2/ACADVL/APLP2/LRP1/ACBD3/NRP1/PAFAH1B1/TGFBR3	16
GO:0004859	phospholipase inhibitor activity	2/781	13/18367	0.103345212939871	0.453688249441823	ANXA1/ANXA4	2
GO:0005542	folic acid binding	2/781	13/18367	0.103345212939871	0.453688249441823	SLC19A1/MTHFS	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/781	13/18367	0.103345212939871	0.453688249441823	SLC26A2/SLC13A4	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/781	13/18367	0.103345212939871	0.453688249441823	DUSP5/DUSP9	2
GO:0042301	phosphate ion binding	2/781	13/18367	0.103345212939871	0.453688249441823	GNG12/PNP	2
GO:0051011	microtubule minus-end binding	2/781	13/18367	0.103345212939871	0.453688249441823	NUMA1/CAMSAP2	2
GO:0060590	ATPase regulator activity	2/781	13/18367	0.103345212939871	0.453688249441823	BAG1/SIL1	2
GO:0061133	endopeptidase activator activity	2/781	13/18367	0.103345212939871	0.453688249441823	ADRM1/PSMD14	2
GO:0008139	nuclear localization sequence binding	3/781	27/18367	0.105366154887278	0.453688249441823	KPNA6/NFKBIA/TNPO1	3
GO:0035255	ionotropic glutamate receptor binding	3/781	27/18367	0.105366154887278	0.453688249441823	SQSTM1/GNAS/OPHN1	3
GO:0051119	sugar transmembrane transporter activity	3/781	27/18367	0.105366154887278	0.453688249441823	SLC2A1/SLC2A12/SLC2A8	3
GO:0051959	dynein light intermediate chain binding	3/781	27/18367	0.105366154887278	0.453688249441823	HOOK3/DYNLL1/HOOK2	3
GO:0038024	cargo receptor activity	6/781	77/18367	0.10911192971063	0.467547254363908	DAB2/TFRC/OLR1/LDLR/LRP1/COLEC12	6
GO:0001786	phosphatidylserine binding	5/781	60/18367	0.111065951443034	0.47136602358838	SCIN/ANXA6/MME/SYT7/HSPA8	5
GO:0032934	sterol binding	5/781	60/18367	0.111065951443034	0.47136602358838	ANXA6/GRAMD1C/ABCG1/OSBP/INSIG1	5
GO:0015103	inorganic anion transmembrane transporter activity	10/781	152/18367	0.113905925358408	0.478938342245072	SLC26A2/SLC13A4/SLC22A11/FXYD3/CLIC3/GABRE/CLCN3/SLC4A2/SLC12A4/CLDN4	10
GO:0015101	organic cation transmembrane transporter activity	3/781	28/18367	0.114470043467819	0.478938342245072	SLC19A2/SLC19A3/SLC44A1	3
GO:0051861	glycolipid binding	3/781	28/18367	0.114470043467819	0.478938342245072	CLN3/GLTP/MANF	3
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	2/781	14/18367	0.11729863241838	0.486186387640668	GPR87/P2RY6	2
GO:0071837	HMG box domain binding	2/781	14/18367	0.11729863241838	0.486186387640668	GATA3/DLX5	2
GO:0004033	aldo-keto reductase (NADP) activity	3/781	29/18367	0.123858305654249	0.501654416051685	AKR1B1/RDH13/RDH10	3
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	3/781	29/18367	0.123858305654249	0.501654416051685	CDK2/CDKL5/CCND3	3
GO:0046625	sphingolipid binding	3/781	29/18367	0.123858305654249	0.501654416051685	MAP1LC3B/GLTP/CLN8	3
GO:0070717	poly-purine tract binding	3/781	29/18367	0.123858305654249	0.501654416051685	RBMS1/DDX3X/EIF4A3	3
GO:0097472	cyclin-dependent protein kinase activity	3/781	29/18367	0.123858305654249	0.501654416051685	CDK2/CDKL5/CCND3	3
GO:0035591	signaling adaptor activity	6/781	81/18367	0.130246799082573	0.523797665343136	SPAG9/GRIP1/DEDD2/DLG5/SORBS1/MPP7	6
GO:0005452	inorganic anion exchanger activity	2/781	15/18367	0.131687575390664	0.523797665343136	SLC22A11/SLC4A2	2
GO:0070742	C2H2 zinc finger domain binding	2/781	15/18367	0.131687575390664	0.523797665343136	GATA2/SRRM2	2
GO:1901611	phosphatidylglycerol binding	2/781	15/18367	0.131687575390664	0.523797665343136	MME/PITPNA	2
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/781	30/18367	0.133514188471588	0.528692344528119	SLC26A2/SLC19A1/SLC13A3	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4/781	47/18367	0.13837595812097	0.54550877712578	DUSP5/DUSP9/PTP4A1/DUSP3	4
GO:0071813	lipoprotein particle binding	3/781	31/18367	0.143420835827227	0.560415336470264	LDLR/COLEC12/HSPD1	3
GO:0071814	protein-lipid complex binding	3/781	31/18367	0.143420835827227	0.560415336470264	LDLR/COLEC12/HSPD1	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/781	16/18367	0.146449895662411	0.564304352978606	CPEB4/PAIP2	2
GO:0005092	GDP-dissociation inhibitor activity	2/781	16/18367	0.146449895662411	0.564304352978606	EIF5/SH3BP4	2
GO:0016004	phospholipase activator activity	2/781	16/18367	0.146449895662411	0.564304352978606	PDPK1/ARF1	2
GO:0019838	growth factor binding	9/781	141/18367	0.146960885612241	0.564304352978606	EGFR/CRIM1/GHR/FURIN/ERBB3/LIFR/ITGB4/NRP1/TGFBR3	9
GO:0015294	solute:cation symporter activity	7/781	104/18367	0.154219719033656	0.581584491899353	SLC13A4/SLC38A1/SLC6A8/SLC5A6/SLC12A4/SLC20A1/SLC13A3	7
GO:0019887	protein kinase regulator activity	12/781	204/18367	0.160840958686303	0.581584491899353	HSPB1/CDKN1C/HEXIM1/SOCS1/PKIB/ERBB3/DDX3X/GSKIP/RICTOR/CCNC/TAOK1/CCND3	12
GO:0008484	sulfuric ester hydrolase activity	2/781	17/18367	0.161527932714132	0.581584491899353	STS/IDS	2
GO:0008525	phosphatidylcholine transporter activity	2/781	17/18367	0.161527932714132	0.581584491899353	PITPNA/ABCG1	2
GO:0015095	magnesium ion transmembrane transporter activity	2/781	17/18367	0.161527932714132	0.581584491899353	CNNM2/TUSC3	2
GO:0015116	sulfate transmembrane transporter activity	2/781	17/18367	0.161527932714132	0.581584491899353	SLC26A2/SLC13A4	2
GO:0015174	basic amino acid transmembrane transporter activity	2/781	17/18367	0.161527932714132	0.581584491899353	SLC38A9/SLC7A6	2
GO:0030169	low-density lipoprotein particle binding	2/781	17/18367	0.161527932714132	0.581584491899353	LDLR/COLEC12	2
GO:0030275	LRR domain binding	2/781	17/18367	0.161527932714132	0.581584491899353	DDIT3/ERC1	2
GO:0034185	apolipoprotein binding	2/781	17/18367	0.161527932714132	0.581584491899353	LRP1/HSPD1	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/781	17/18367	0.161527932714132	0.581584491899353	B3GNT5/C1GALT1	2
GO:0050780	dopamine receptor binding	2/781	17/18367	0.161527932714132	0.581584491899353	GNA12/GNAS	2
GO:0070628	proteasome binding	2/781	17/18367	0.161527932714132	0.581584491899353	ADRM1/PSMD14	2
GO:0000993	RNA polymerase II complex binding	4/781	50/18367	0.162375376412791	0.581584491899353	NCOA3/GTF2B/BRD4/AGO2	4
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/781	50/18367	0.162375376412791	0.581584491899353	CDKN1C/HEXIM1/CCNC/CCND3	4
GO:0004623	phospholipase A2 activity	3/781	33/18367	0.163918966149761	0.581584491899353	ABHD3/PNPLA8/PRDX6	3
GO:0005154	epidermal growth factor receptor binding	3/781	33/18367	0.163918966149761	0.581584491899353	VAV3/ARF4/EFEMP1	3
GO:0008200	ion channel inhibitor activity	3/781	33/18367	0.163918966149761	0.581584491899353	RASA1/NEDD4L/COMMD1	3
GO:0031369	translation initiation factor binding	3/781	33/18367	0.163918966149761	0.581584491899353	EIF5/EIF2S2/DDX3X	3
GO:0016247	channel regulator activity	9/781	145/18367	0.165136612194506	0.583570418392538	PRKCZ/SGK1/FXYD3/RASA1/NEDD4L/BCL2/AKAP9/PRSS8/COMMD1	9
GO:0008242	omega peptidase activity	8/781	126/18367	0.168335911889707	0.587573527657057	OTUB2/GGH/USP43/TANK/USP8/USP16/PSMD14/USP47	8
GO:0009055	electron transfer activity	8/781	126/18367	0.168335911889707	0.587573527657057	CYP19A1/FDX1/AKR1B1/NDUFA6/COX4I1/COX7B/COX6A1/NDUFB9	8
GO:0005518	collagen binding	5/781	69/18367	0.169559869388582	0.587573527657057	CTSL/PCOLCE2/ADGRG1/C1QTNF1/PPIB	5
GO:0016831	carboxy-lyase activity	3/781	34/18367	0.174476915002935	0.587573527657057	DDT/PDXDC1/AZIN1	3
GO:0045505	dynein intermediate chain binding	3/781	34/18367	0.174476915002935	0.587573527657057	HOOK3/DYNLL1/PAFAH1B1	3
GO:0001098	basal transcription machinery binding	5/781	70/18367	0.176694625063181	0.587573527657057	NCOA3/EDF1/GTF2B/BRD4/AGO2	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/781	70/18367	0.176694625063181	0.587573527657057	NCOA3/EDF1/GTF2B/BRD4/AGO2	5
GO:0000295	adenine nucleotide transmembrane transporter activity	2/781	18/18367	0.176868243387186	0.587573527657057	SLC19A1/SLC25A5	2
GO:0004438	phosphatidylinositol-3-phosphatase activity	2/781	18/18367	0.176868243387186	0.587573527657057	MTMR10/SYNJ1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/781	18/18367	0.176868243387186	0.587573527657057	SLC19A1/SLC25A5	2
GO:0046624	sphingolipid transporter activity	2/781	18/18367	0.176868243387186	0.587573527657057	ATP10D/GLTP	2
GO:0050811	GABA receptor binding	2/781	18/18367	0.176868243387186	0.587573527657057	GABARAPL1/GABARAPL2	2
GO:0055102	lipase inhibitor activity	2/781	18/18367	0.176868243387186	0.587573527657057	ANXA1/ANXA4	2
GO:0060229	lipase activator activity	2/781	18/18367	0.176868243387186	0.587573527657057	PDPK1/ARF1	2
GO:0070122	isopeptidase activity	2/781	18/18367	0.176868243387186	0.587573527657057	PSMD7/PSMD14	2
GO:0098641	cadherin binding involved in cell-cell adhesion	2/781	18/18367	0.176868243387186	0.587573527657057	ANXA1/KRT18	2
GO:0005539	glycosaminoglycan binding	13/781	230/18367	0.182361630631996	0.603562561084256	PGF/GREM2/APP/ANXA6/SMOC1/LRPAP1/PCOLCE2/ADGRG1/LAMC2/APLP2/NRP1/PAFAH1B1/TGFBR3	13
GO:0048029	monosaccharide binding	5/781	71/18367	0.183940856679412	0.606526170537691	LMAN2/EGLN2/BSG/COLEC12/SLC2A8	5
GO:0015298	solute:cation antiporter activity	3/781	35/18367	0.185218683487352	0.608477675012152	SLC3A2/CLCN3/SLC9A1	3
GO:0008047	enzyme activator activity	7/781	110/18367	0.187823135244102	0.614756903917043	NUPR1/GNAS/PPP1R12B/PDPK1/ARF1/AZIN1/DDOST	7
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5/781	72/18367	0.19129401146087	0.615805659529755	NDUFA6/COX4I1/COX7B/COX6A1/NDUFB9	5
GO:0000339	RNA cap binding	2/781	19/18367	0.192421348231688	0.615805659529755	AGO2/EIF4A1	2
GO:0035613	RNA stem-loop binding	2/781	19/18367	0.192421348231688	0.615805659529755	DDX3X/EIF4A3	2
GO:0052742	phosphatidylinositol kinase activity	2/781	19/18367	0.192421348231688	0.615805659529755	PIK3C2A/PI4K2A	2
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	2/781	19/18367	0.192421348231688	0.615805659529755	MTMR10/SYNJ1	2
GO:0005506	iron ion binding	9/781	151/18367	0.19426377751961	0.615805659529755	CYP19A1/CYP11A1/FDX1/CYP2J2/TET2/EGLN2/CALR/CDO1/ACO2	9
GO:0030695	GTPase regulator activity	25/781	488/18367	0.194266860309779	0.615805659529755	NUCB2/EPS8L1/FAM13A/RASA1/VAV3/RASAL2/EIF5/SH3BP4/FGD6/TBC1D9/WASL/ARF4/ARHGAP24/OPHN1/TBC1D20/RAPGEF1/FNIP1/RABGAP1/EIF2B2/NRP1/ARHGAP18/BNIP2/ERRFI1/RP2/IQGAP2	25
GO:0060589	nucleoside-triphosphatase regulator activity	25/781	488/18367	0.194266860309779	0.615805659529755	NUCB2/EPS8L1/FAM13A/RASA1/VAV3/RASAL2/EIF5/SH3BP4/FGD6/TBC1D9/WASL/ARF4/ARHGAP24/OPHN1/TBC1D20/RAPGEF1/FNIP1/RABGAP1/EIF2B2/NRP1/ARHGAP18/BNIP2/ERRFI1/RP2/IQGAP2	25
GO:0005484	SNAP receptor activity	3/781	36/18367	0.196127964722914	0.615805659529755	STX5/SNAP23/GOSR1	3
GO:0015248	sterol transporter activity	3/781	36/18367	0.196127964722914	0.615805659529755	GRAMD1C/ABCG1/OSBP	3
GO:0061631	ubiquitin conjugating enzyme activity	3/781	36/18367	0.196127964722914	0.615805659529755	UBE2B/UBE2A/UBE2H	3
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4/781	54/18367	0.196474635453124	0.615805659529755	P4HB/TET2/EGLN2/KDM5B	4
GO:0106306	protein serine phosphatase activity	5/781	73/18367	0.198749467098361	0.618564130934196	DUSP5/DUSP9/DUSP3/PHLPP1/PPP1CB	5
GO:0106307	protein threonine phosphatase activity	5/781	73/18367	0.198749467098361	0.618564130934196	DUSP5/DUSP9/DUSP3/PHLPP1/PPP1CB	5
GO:0044325	transmembrane transporter binding	8/781	133/18367	0.205631738099689	0.625835604028714	TCAF1/NEDD4L/HERPUD1/AKAP9/ID2/CTNNB1/ACTN4/AP2M1	8
GO:0004843	thiol-dependent deubiquitinase	7/781	113/18367	0.205658081612463	0.625835604028714	OTUB2/USP43/TANK/USP8/USP16/PSMD14/USP47	7
GO:0005254	chloride channel activity	5/781	74/18367	0.2063025422696	0.625835604028714	FXYD3/CLIC3/GABRE/CLCN3/CLDN4	5
GO:0016409	palmitoyltransferase activity	3/781	37/18367	0.20718872339755	0.625835604028714	SPTSSA/ZDHHC3/ZDHHC20	3
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/781	20/18367	0.208141491757013	0.625835604028714	CEBPB/GTF2B	2
GO:0003756	protein disulfide isomerase activity	2/781	20/18367	0.208141491757013	0.625835604028714	P4HB/PDIA3	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/781	20/18367	0.208141491757013	0.625835604028714	SAMD8/PTDSS1	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/781	20/18367	0.208141491757013	0.625835604028714	P4HB/PDIA3	2
GO:0031690	adrenergic receptor binding	2/781	20/18367	0.208141491757013	0.625835604028714	ARRDC3/GNAS	2
GO:0061608	nuclear import signal receptor activity	2/781	20/18367	0.208141491757013	0.625835604028714	KPNA6/TNPO1	2
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	6/781	94/18367	0.210521379483881	0.630852917575009	MAN1A2/NEU1/EDEM1/FUCA1/MAN1C1/GLA	6
GO:0101005	deubiquitinase activity	7/781	114/18367	0.211741932590754	0.632374054572386	OTUB2/USP43/TANK/USP8/USP16/PSMD14/USP47	7
GO:0050840	extracellular matrix binding	4/781	56/18367	0.214283540119642	0.637817114382961	LYPD3/TINAGL1/SMOC1/ADGRG1	4
GO:0008395	steroid hydroxylase activity	3/781	38/18367	0.218385235191668	0.642964242300773	CYP19A1/CYP11A1/CYP2J2	3
GO:0005548	phospholipid transporter activity	4/781	57/18367	0.223350134335442	0.642964242300773	PITPNA/ABCG1/GLTP/PRELID1	4
GO:0043175	RNA polymerase core enzyme binding	4/781	57/18367	0.223350134335442	0.642964242300773	NCOA3/GTF2B/BRD4/AGO2	4
GO:0001614	purinergic nucleotide receptor activity	2/781	21/18367	0.223986415863516	0.642964242300773	GPR87/P2RY6	2
GO:0001848	complement binding	2/781	21/18367	0.223986415863516	0.642964242300773	CALR/CD59	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/781	21/18367	0.223986415863516	0.642964242300773	SLC19A1/SLC25A5	2
GO:0016502	nucleotide receptor activity	2/781	21/18367	0.223986415863516	0.642964242300773	GPR87/P2RY6	2
GO:0070577	lysine-acetylated histone binding	2/781	21/18367	0.223986415863516	0.642964242300773	BRD2/BRD4	2
GO:0140033	acetylation-dependent protein binding	2/781	21/18367	0.223986415863516	0.642964242300773	BRD2/BRD4	2
GO:0140416	transcription regulator inhibitor activity	2/781	21/18367	0.223986415863516	0.642964242300773	DDIT3/ID2	2
GO:1990381	ubiquitin-specific protease binding	2/781	21/18367	0.223986415863516	0.642964242300773	VCP/LCOR	2
GO:0003724	RNA helicase activity	5/781	77/18367	0.229499998951588	0.656666126032447	DDX28/DHX36/DDX3X/EIF4A3/EIF4A1	5
GO:0004896	cytokine receptor activity	6/781	97/18367	0.231122171515239	0.659181241588478	CSF3R/GHR/IL10RB/LIFR/PRLR/CSF2RA	6
GO:0046982	protein heterodimerization activity	17/781	328/18367	0.234002321499148	0.660115190421214	CEBPB/NFYB/ATF3/BCL2/DDIT3/EPAS1/RRAGC/MAFG/BHLHE40/TENM3/ABCG1/P4HB/TPM4/ERBB3/TAF13/ATF1/PAFAH1B1	17
GO:0000062	fatty-acyl-CoA binding	2/781	22/18367	0.239917145770193	0.660115190421214	ACADVL/ACBD3	2
GO:0005537	mannose binding	2/781	22/18367	0.239917145770193	0.660115190421214	LMAN2/BSG	2
GO:0015296	anion:cation symporter activity	2/781	22/18367	0.239917145770193	0.660115190421214	SLC13A4/SLC12A4	2
GO:0030742	GTP-dependent protein binding	2/781	22/18367	0.239917145770193	0.660115190421214	EEA1/RAB5B	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/781	22/18367	0.239917145770193	0.660115190421214	SERPINB9/TNFAIP8	2
GO:0050321	tau-protein kinase activity	2/781	22/18367	0.239917145770193	0.660115190421214	SIK3/TAOK1	2
GO:0070034	telomerase RNA binding	2/781	22/18367	0.239917145770193	0.660115190421214	DHX36/XRN1	2
GO:0120020	cholesterol transfer activity	2/781	22/18367	0.239917145770193	0.660115190421214	GRAMD1C/ABCG1	2
GO:0019955	cytokine binding	8/781	139/18367	0.239943544467507	0.660115190421214	CSF3R/GREM2/GHR/LIFR/PRLR/NRP1/CSF2RA/TGFBR3	8
GO:0099106	ion channel regulator activity	8/781	139/18367	0.239943544467507	0.660115190421214	PRKCZ/SGK1/FXYD3/RASA1/NEDD4L/AKAP9/PRSS8/COMMD1	8
GO:0015144	carbohydrate transmembrane transporter activity	3/781	40/18367	0.241124376207974	0.660115190421214	SLC2A1/SLC2A12/SLC2A8	3
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	3/781	40/18367	0.241124376207974	0.660115190421214	CYP19A1/HMOX1/CYP2J2	3
GO:0008186	ATP-dependent activity, acting on RNA	5/781	79/18367	0.245365494701308	0.66965905784634	DDX28/DHX36/DDX3X/EIF4A3/EIF4A1	5
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	16/781	310/18367	0.247595368607201	0.673672061210392	TBX3/NFE2L3/CEBPB/GATA3/TFAP2A/OVOL1/PEG3/ATF3/HES1/MAFK/MXD1/NFIL3/BHLHE40/ZNF750/PPARD/NR2F6	16
GO:0030331	estrogen receptor binding	3/781	41/18367	0.252637395944746	0.685288593892935	CTNNB1/LCOR/TACC1	3
GO:0015299	solute:proton antiporter activity	2/781	23/18367	0.255897787787338	0.68574422286214	CLCN3/SLC9A1	2
GO:0017025	TBP-class protein binding	2/781	23/18367	0.255897787787338	0.68574422286214	GTF2B/TAF13	2
GO:0030215	semaphorin receptor binding	2/781	23/18367	0.255897787787338	0.68574422286214	SEMA6A/SEMA7A	2
GO:1901567	fatty acid derivative binding	2/781	23/18367	0.255897787787338	0.68574422286214	ACADVL/ACBD3	2
GO:0001217	DNA-binding transcription repressor activity	16/781	313/18367	0.259541891018809	0.693414630523142	TBX3/NFE2L3/CEBPB/GATA3/TFAP2A/OVOL1/PEG3/ATF3/HES1/MAFK/MXD1/NFIL3/BHLHE40/ZNF750/PPARD/NR2F6	16
GO:0005507	copper ion binding	4/781	61/18367	0.26051423420446	0.693922299517586	F5/COX17/COMMD1/SOD1	4
GO:0001046	core promoter sequence-specific DNA binding	3/781	42/18367	0.264226995818228	0.699609985942591	CEBPB/GTF2B/AGO2	3
GO:0015036	disulfide oxidoreductase activity	3/781	42/18367	0.264226995818228	0.699609985942591	P4HB/PDIA3/TXNL1	3
GO:0003697	single-stranded DNA binding	7/781	123/18367	0.269169396573927	0.710389120059307	ANXA1/TOP1/NABP1/DHX36/RBMS1/SUB1/HSPD1	7
GO:0015293	symporter activity	8/781	144/18367	0.269899812243502	0.710389120059307	SLC13A4/SLC38A1/SLC6A8/SLC5A6/SLC12A4/SLC16A3/SLC20A1/SLC13A3	8
GO:0019789	SUMO transferase activity	2/781	24/18367	0.271895338315914	0.713524157059809	MDM2/UBE2I	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/781	124/18367	0.275803046794167	0.721643960195948	HSD17B1/HSD11B2/AKR1B1/RDH13/HIBADH/RDH10/LDHB	7
GO:0004620	phospholipase activity	6/781	104/18367	0.281372409124684	0.733631312174766	HMOX1/ABHD3/GDPD5/PNPLA8/PDIA3/PRDX6	6
GO:0019783	ubiquitin-like protein-specific protease activity	7/781	125/18367	0.282478242957857	0.733631312174766	OTUB2/USP43/TANK/USP8/USP16/PSMD14/USP47	7
GO:0030165	PDZ domain binding	5/781	84/18367	0.286149762267221	0.733631312174766	GNG12/CRIM1/ERC1/CLCN3/TGFBR3	5
GO:0008266	poly(U) RNA binding	2/781	25/18367	0.287879503486406	0.733631312174766	RBMS1/MSI2	2
GO:0008327	methyl-CpG binding	2/781	25/18367	0.287879503486406	0.733631312174766	ZBTB38/MBD3	2
GO:0035035	histone acetyltransferase binding	2/781	25/18367	0.287879503486406	0.733631312174766	CEBPB/GLI3	2
GO:0120227	acyl-CoA binding	2/781	25/18367	0.287879503486406	0.733631312174766	ACADVL/ACBD3	2
GO:0019207	kinase regulator activity	12/781	233/18367	0.289212000081673	0.733631312174766	HSPB1/CDKN1C/HEXIM1/SOCS1/PKIB/ERBB3/DDX3X/GSKIP/RICTOR/CCNC/TAOK1/CCND3	12
GO:0008234	cysteine-type peptidase activity	10/781	190/18367	0.290051312510203	0.733631312174766	OTUB2/CTSL/GGH/USP43/PDIA3/TANK/USP8/USP16/PSMD14/USP47	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	9/781	170/18367	0.298365843720912	0.733631312174766	CYP19A1/CYP11A1/HMOX1/KMO/CYP2J2/P4HB/TET2/EGLN2/KDM5B	9
GO:0042562	hormone binding	5/781	86/18367	0.302811220939079	0.733631312174766	SLC40A1/EGFR/GHR/CALR/PRLR	5
GO:0004364	glutathione transferase activity	2/781	26/18367	0.303822528879479	0.733631312174766	GSTA3/GSTA4	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2/781	26/18367	0.303822528879479	0.733631312174766	ZDHHC3/ZDHHC20	2
GO:0019707	protein-cysteine S-acyltransferase activity	2/781	26/18367	0.303822528879479	0.733631312174766	ZDHHC3/ZDHHC20	2
GO:0030371	translation repressor activity	2/781	26/18367	0.303822528879479	0.733631312174766	CPEB4/PAIP2	2
GO:0042974	retinoic acid receptor binding	2/781	26/18367	0.303822528879479	0.733631312174766	TACC1/ACTN4	2
GO:0097602	cullin family protein binding	2/781	26/18367	0.303822528879479	0.733631312174766	SKP1/DDB1	2
GO:0002039	p53 binding	4/781	66/18367	0.308416459046748	0.733631312174766	PTTG1IP/MDM2/BRD4/HSPD1	4
GO:0016298	lipase activity	7/781	129/18367	0.309544727219093	0.733631312174766	HMOX1/ABHD3/GDPD5/PNPLA8/PDIA3/PNPLA2/PRDX6	7
GO:0140296	general transcription initiation factor binding	3/781	46/18367	0.311083107393223	0.733631312174766	EDF1/GTF2B/TAF13	3
GO:0005253	anion channel activity	5/781	87/18367	0.311197650183071	0.733631312174766	FXYD3/CLIC3/GABRE/CLCN3/CLDN4	5
GO:0017124	SH3 domain binding	7/781	130/18367	0.316390343951912	0.733631312174766	FMN1/RAPGEF1/UVRAG/CRB3/SYNJ1/ERRFI1/USP8	7
GO:0015215	nucleotide transmembrane transporter activity	2/781	27/18367	0.319699038798856	0.733631312174766	SLC19A1/SLC25A5	2
GO:0015491	cation:cation antiporter activity	2/781	27/18367	0.319699038798856	0.733631312174766	SLC3A2/SLC9A1	2
GO:0016866	intramolecular transferase activity	2/781	27/18367	0.319699038798856	0.733631312174766	CYP2J2/BPGM	2
GO:0023026	MHC class II protein complex binding	2/781	27/18367	0.319699038798856	0.733631312174766	HSP90AA1/HSPA8	2
GO:0030507	spectrin binding	2/781	27/18367	0.319699038798856	0.733631312174766	MYO10/CAMSAP2	2
GO:0045499	chemorepellent activity	2/781	27/18367	0.319699038798856	0.733631312174766	SEMA6A/SEMA7A	2
GO:0048027	mRNA 5'-UTR binding	2/781	27/18367	0.319699038798856	0.733631312174766	DHX36/DDX3X	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/781	27/18367	0.319699038798856	0.733631312174766	ATP10D/ABCG1	2
GO:0015081	sodium ion transmembrane transporter activity	8/781	152/18367	0.31978534657976	0.733631312174766	SLC13A4/SLC3A2/SLC38A1/SLC6A8/SLC5A6/SLC9A1/SLC20A1/SLC13A3	8
GO:0005096	GTPase activator activity	22/781	462/18367	0.322583897396191	0.733631312174766	NUCB2/EPS8L1/FAM13A/RASA1/VAV3/RASAL2/FGD6/TBC1D9/ARF4/ARHGAP24/OPHN1/TBC1D20/RAPGEF1/FNIP1/RABGAP1/EIF2B2/NRP1/ARHGAP18/BNIP2/ERRFI1/RP2/IQGAP2	22
GO:0035254	glutamate receptor binding	3/781	47/18367	0.322858594843604	0.733631312174766	SQSTM1/GNAS/OPHN1	3
GO:0005319	lipid transporter activity	8/781	154/18367	0.332535917346229	0.733631312174766	ATP10D/SLC2A1/GRAMD1C/PITPNA/ABCG1/GLTP/PRELID1/OSBP	8
GO:0015026	coreceptor activity	3/781	48/18367	0.334635139288248	0.733631312174766	LRP1/NRP1/TGFBR3	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3/781	48/18367	0.334635139288248	0.733631312174766	RIMKLB/MTHFS/ASNSD1	3
GO:0070888	E-box binding	3/781	48/18367	0.334635139288248	0.733631312174766	GATA3/HES1/BHLHE40	3
GO:0001968	fibronectin binding	2/781	28/18367	0.33548588459355	0.733631312174766	CTSL/FBLN1	2
GO:0003785	actin monomer binding	2/781	28/18367	0.33548588459355	0.733631312174766	COBLL1/MTSS1	2
GO:0004629	phospholipase C activity	2/781	28/18367	0.33548588459355	0.733631312174766	GDPD5/PDIA3	2
GO:0008187	poly-pyrimidine tract binding	2/781	28/18367	0.33548588459355	0.733631312174766	RBMS1/MSI2	2
GO:0043236	laminin binding	2/781	28/18367	0.33548588459355	0.733631312174766	LYPD3/TINAGL1	2
GO:0042393	histone binding	12/781	244/18367	0.344450901717256	0.733631312174766	CTSL/CDYL/KMT2C/MLLT6/BRD2/KDM5B/SUPT6H/RBBP7/BRD4/CHD2/MORC4/USP16	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	11/781	222/18367	0.345259511976752	0.733631312174766	ALAS1/SPTSSA/NCOA3/SAT1/TGM2/ABHD5/GTF2B/ZDHHC3/ZDHHC20/PNPLA2/PRDX6	11
GO:0043539	protein serine/threonine kinase activator activity	3/781	49/18367	0.346401817236029	0.733631312174766	DDX3X/RICTOR/TAOK1	3
GO:0004857	enzyme inhibitor activity	4/781	70/18367	0.34733078964773	0.733631312174766	ANXA1/PPP1R12B/DYNLL1/ANXA4	4
GO:0005520	insulin-like growth factor binding	2/781	29/18367	0.351162001552017	0.733631312174766	CRIM1/ITGB4	2
GO:0033612	receptor serine/threonine kinase binding	2/781	29/18367	0.351162001552017	0.733631312174766	GDF15/MDM2	2
GO:0005516	calmodulin binding	10/781	201/18367	0.351444113238332	0.733631312174766	EGFR/KCNN4/MYO10/EEA1/EDF1/SYT7/MYO6/SLC9A1/CAMSAP2/IQGAP2	10
GO:0001094	TFIID-class transcription factor complex binding	1/781	10/18367	0.352497935902517	0.733631312174766	EDF1	1
GO:0004465	lipoprotein lipase activity	1/781	10/18367	0.352497935902517	0.733631312174766	PNPLA2	1
GO:0005432	calcium:sodium antiporter activity	1/781	10/18367	0.352497935902517	0.733631312174766	SLC3A2	1
GO:0005528	FK506 binding	1/781	10/18367	0.352497935902517	0.733631312174766	FKBP2	1
GO:0008097	5S rRNA binding	1/781	10/18367	0.352497935902517	0.733631312174766	MDM2	1
GO:0008190	eukaryotic initiation factor 4E binding	1/781	10/18367	0.352497935902517	0.733631312174766	DDX3X	1
GO:0008519	ammonium transmembrane transporter activity	1/781	10/18367	0.352497935902517	0.733631312174766	SLC12A4	1
GO:0008526	phosphatidylinositol transfer activity	1/781	10/18367	0.352497935902517	0.733631312174766	PITPNA	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/781	10/18367	0.352497935902517	0.733631312174766	UBA5	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/781	10/18367	0.352497935902517	0.733631312174766	SLC35B4	1
GO:0015232	heme transmembrane transporter activity	1/781	10/18367	0.352497935902517	0.733631312174766	PGRMC2	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/781	10/18367	0.352497935902517	0.733631312174766	PIK3C2A	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/781	10/18367	0.352497935902517	0.733631312174766	CYB5R1	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/781	10/18367	0.352497935902517	0.733631312174766	BPGM	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/781	10/18367	0.352497935902517	0.733631312174766	ASNSD1	1
GO:0019531	oxalate transmembrane transporter activity	1/781	10/18367	0.352497935902517	0.733631312174766	SLC26A2	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/781	10/18367	0.352497935902517	0.733631312174766	HDAC5	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/781	10/18367	0.352497935902517	0.733631312174766	HDAC5	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/781	10/18367	0.352497935902517	0.733631312174766	SYNJ1	1
GO:0035374	chondroitin sulfate binding	1/781	10/18367	0.352497935902517	0.733631312174766	ANXA6	1
GO:0035612	AP-2 adaptor complex binding	1/781	10/18367	0.352497935902517	0.733631312174766	AAK1	1
GO:0045503	dynein light chain binding	1/781	10/18367	0.352497935902517	0.733631312174766	HOOK3	1
GO:0046030	inositol trisphosphate phosphatase activity	1/781	10/18367	0.352497935902517	0.733631312174766	SYNJ1	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	1/781	10/18367	0.352497935902517	0.733631312174766	ABHD3	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/781	10/18367	0.352497935902517	0.733631312174766	PIK3C2A	1
GO:0070567	cytidylyltransferase activity	1/781	10/18367	0.352497935902517	0.733631312174766	CMAS	1
GO:0120016	sphingolipid transfer activity	1/781	10/18367	0.352497935902517	0.733631312174766	GLTP	1
GO:0051213	dioxygenase activity	5/781	92/18367	0.353505135702735	0.733631312174766	P4HB/TET2/EGLN2/KDM5B/CDO1	5
GO:0004713	protein tyrosine kinase activity	7/781	136/18367	0.35793797975533	0.733631312174766	EGFR/EPHB4/CRIM1/ERBB3/SCYL1/NRP1/EFEMP1	7
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	7/781	136/18367	0.35793797975533	0.733631312174766	HSD17B1/HSD11B2/AKR1B1/RDH13/HIBADH/RDH10/LDHB	7
GO:0015485	cholesterol binding	3/781	50/18367	0.358148185799215	0.733631312174766	ANXA6/GRAMD1C/ABCG1	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3/781	50/18367	0.358148185799215	0.733631312174766	SLC19A1/SLC25A5/SLC35B4	3
GO:0005343	organic acid:sodium symporter activity	2/781	30/18367	0.366708273914905	0.733631312174766	SLC38A1/SLC13A3	2
GO:0016417	S-acyltransferase activity	2/781	30/18367	0.366708273914905	0.733631312174766	ZDHHC3/ZDHHC20	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/781	30/18367	0.366708273914905	0.733631312174766	HSD17B1/HSD11B2	2
GO:0003678	DNA helicase activity	4/781	72/18367	0.366837847867429	0.733631312174766	ANXA1/DHX36/DDX3X/CHD2	4
GO:0004601	peroxidase activity	3/781	51/18367	0.369864280492084	0.733631312174766	GPX3/MGST3/PRDX6	3
GO:0016410	N-acyltransferase activity	5/781	94/18367	0.370521580342295	0.733631312174766	ALAS1/NCOA3/SAT1/TGM2/GTF2B	5
GO:0016746	acyltransferase activity	12/781	250/18367	0.375386192971132	0.733631312174766	ALAS1/SPTSSA/NCOA3/SAT1/TGM2/ABHD5/KMT2C/GTF2B/ZDHHC3/ZDHHC20/PNPLA2/PRDX6	12
GO:0140104	molecular carrier activity	4/781	73/18367	0.376582101825057	0.733631312174766	KPNA6/TNPO1/COX17/HSPA8	4
GO:0005078	MAP-kinase scaffold activity	1/781	11/18367	0.380045961835956	0.733631312174766	SPAG9	1
GO:0005247	voltage-gated chloride channel activity	1/781	11/18367	0.380045961835956	0.733631312174766	CLCN3	1
GO:0005347	ATP transmembrane transporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SLC25A5	1
GO:0005436	sodium:phosphate symporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SLC20A1	1
GO:0005536	glucose binding	1/781	11/18367	0.380045961835956	0.733631312174766	SLC2A8	1
GO:0008503	benzodiazepine receptor activity	1/781	11/18367	0.380045961835956	0.733631312174766	GABRE	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/781	11/18367	0.380045961835956	0.733631312174766	PKIB	1
GO:0015368	calcium:cation antiporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SLC3A2	1
GO:0015386	potassium:proton antiporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SLC9A1	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/781	11/18367	0.380045961835956	0.733631312174766	P4HB	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/781	11/18367	0.380045961835956	0.733631312174766	ARG2	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/781	11/18367	0.380045961835956	0.733631312174766	GLCE	1
GO:0022889	serine transmembrane transporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SERINC5	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/781	11/18367	0.380045961835956	0.733631312174766	HSD17B1	1
GO:0035197	siRNA binding	1/781	11/18367	0.380045961835956	0.733631312174766	AGO2	1
GO:0035673	oligopeptide transmembrane transporter activity	1/781	11/18367	0.380045961835956	0.733631312174766	SLC13A3	1
GO:0042608	T cell receptor binding	1/781	11/18367	0.380045961835956	0.733631312174766	EPS8L1	1
GO:0043560	insulin receptor substrate binding	1/781	11/18367	0.380045961835956	0.733631312174766	PRKCZ	1
GO:0051400	BH domain binding	1/781	11/18367	0.380045961835956	0.733631312174766	BCL2	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/781	11/18367	0.380045961835956	0.733631312174766	SYNJ1	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	1/781	11/18367	0.380045961835956	0.733631312174766	ABHD3	1
GO:0070513	death domain binding	1/781	11/18367	0.380045961835956	0.733631312174766	BCL2	1
GO:0102545	phosphatidyl phospholipase B activity	1/781	11/18367	0.380045961835956	0.733631312174766	PNPLA8	1
GO:1901612	cardiolipin binding	1/781	11/18367	0.380045961835956	0.733631312174766	MME	1
GO:0004879	nuclear receptor activity	3/781	52/18367	0.381540611551914	0.733631312174766	ESRRG/PPARD/NR2F6	3
GO:0016830	carbon-carbon lyase activity	3/781	52/18367	0.381540611551914	0.733631312174766	DDT/PDXDC1/AZIN1	3
GO:0017046	peptide hormone binding	3/781	52/18367	0.381540611551914	0.733631312174766	SLC40A1/GHR/PRLR	3
GO:0098531	ligand-activated transcription factor activity	3/781	52/18367	0.381540611551914	0.733631312174766	ESRRG/PPARD/NR2F6	3
GO:0000146	microfilament motor activity	2/781	31/18367	0.382107407576124	0.733631312174766	MYO10/MYO6	2
GO:0016411	acylglycerol O-acyltransferase activity	2/781	31/18367	0.382107407576124	0.733631312174766	ABHD5/PNPLA2	2
GO:0031210	phosphatidylcholine binding	2/781	31/18367	0.382107407576124	0.733631312174766	PITPNA/CHMP2A	2
GO:0042910	xenobiotic transmembrane transporter activity	2/781	31/18367	0.382107407576124	0.733631312174766	SLC2A1/SLC19A1	2
GO:0140142	nucleocytoplasmic carrier activity	2/781	31/18367	0.382107407576124	0.733631312174766	KPNA6/TNPO1	2
GO:0070851	growth factor receptor binding	7/781	141/18367	0.392917521168708	0.733631312174766	PGF/GATA3/VAV3/APP/ERN1/ARF4/EFEMP1	7
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/781	53/18367	0.393168158945203	0.733631312174766	SLC19A1/SLC25A5/SLC35B4	3
GO:0001223	transcription coactivator binding	2/781	32/18367	0.397343810063746	0.733631312174766	EPAS1/PPARD	2
GO:0008378	galactosyltransferase activity	2/781	32/18367	0.397343810063746	0.733631312174766	B3GNT5/C1GALT1	2
GO:0015605	organophosphate ester transmembrane transporter activity	2/781	32/18367	0.397343810063746	0.733631312174766	SLC19A1/SLC25A5	2
GO:0031624	ubiquitin conjugating enzyme binding	2/781	32/18367	0.397343810063746	0.733631312174766	SIAH1/SIAH2	2
GO:0071889	14-3-3 protein binding	2/781	32/18367	0.397343810063746	0.733631312174766	PRKCZ/IRS2	2
GO:0004722	protein serine/threonine phosphatase activity	5/781	98/18367	0.404532273499189	0.733631312174766	DUSP5/DUSP9/DUSP3/PHLPP1/PPP1CB	5
GO:0008374	O-acyltransferase activity	3/781	54/18367	0.404738366209443	0.733631312174766	ABHD5/PNPLA2/PRDX6	3
GO:0000340	RNA 7-methylguanosine cap binding	1/781	12/18367	0.406423391766557	0.733631312174766	AGO2	1
GO:0003995	acyl-CoA dehydrogenase activity	1/781	12/18367	0.406423391766557	0.733631312174766	ACADVL	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/781	12/18367	0.406423391766557	0.733631312174766	AKR1B1	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/781	12/18367	0.406423391766557	0.733631312174766	TGFBR3	1
GO:0005095	GTPase inhibitor activity	1/781	12/18367	0.406423391766557	0.733631312174766	IQGAP2	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/781	12/18367	0.406423391766557	0.733631312174766	SLC35B4	1
GO:0005527	macrolide binding	1/781	12/18367	0.406423391766557	0.733631312174766	FKBP2	1
GO:0008174	mRNA methyltransferase activity	1/781	12/18367	0.406423391766557	0.733631312174766	RNMT	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/781	12/18367	0.406423391766557	0.733631312174766	BRD4	1
GO:0008429	phosphatidylethanolamine binding	1/781	12/18367	0.406423391766557	0.733631312174766	MAP1LC3A	1
GO:0015269	calcium-activated potassium channel activity	1/781	12/18367	0.406423391766557	0.733631312174766	KCNN4	1
GO:0017154	semaphorin receptor activity	1/781	12/18367	0.406423391766557	0.733631312174766	NRP1	1
GO:0017166	vinculin binding	1/781	12/18367	0.406423391766557	0.733631312174766	UTRN	1
GO:0022858	alanine transmembrane transporter activity	1/781	12/18367	0.406423391766557	0.733631312174766	SLC3A2	1
GO:0030955	potassium ion binding	1/781	12/18367	0.406423391766557	0.733631312174766	PDXK	1
GO:0033130	acetylcholine receptor binding	1/781	12/18367	0.406423391766557	0.733631312174766	RER1	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/781	12/18367	0.406423391766557	0.733631312174766	PIK3C2A	1
GO:0043422	protein kinase B binding	1/781	12/18367	0.406423391766557	0.733631312174766	SRSF5	1
GO:0046790	virion binding	1/781	12/18367	0.406423391766557	0.733631312174766	TSG101	1
GO:0061578	Lys63-specific deubiquitinase activity	1/781	12/18367	0.406423391766557	0.733631312174766	PSMD14	1
GO:0097677	STAT family protein binding	1/781	12/18367	0.406423391766557	0.733631312174766	CEBPA	1
GO:0019199	transmembrane receptor protein kinase activity	7/781	143/18367	0.406929656809453	0.733631312174766	EGFR/EPHB4/CRIM1/ERBB3/NRP1/TGFBR3/EFEMP1	7
GO:0001530	lipopolysaccharide binding	2/781	33/18367	0.412403477413035	0.741991652059558	PSMB4/HSPD1	2
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/781	55/18367	0.416243133269031	0.742054413207768	GPX3/MGST3/PRDX6	3
GO:0030170	pyridoxal phosphate binding	3/781	55/18367	0.416243133269031	0.742054413207768	ALAS1/PDXK/PDXDC1	3
GO:0016229	steroid dehydrogenase activity	2/781	34/18367	0.427273887563666	0.742054413207768	HSD17B1/HSD11B2	2
GO:0035198	miRNA binding	2/781	34/18367	0.427273887563666	0.742054413207768	NEAT1/AGO2	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/781	34/18367	0.427273887563666	0.742054413207768	MTMR10/SYNJ1	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/781	56/18367	0.427674808352958	0.742054413207768	SERPINB9/TNFAIP8/CAST	3
GO:0070279	vitamin B6 binding	3/781	56/18367	0.427674808352958	0.742054413207768	ALAS1/PDXK/PDXDC1	3
GO:0004652	polynucleotide adenylyltransferase activity	1/781	13/18367	0.431679906668781	0.742054413207768	PAPOLA	1
GO:0008035	high-density lipoprotein particle binding	1/781	13/18367	0.431679906668781	0.742054413207768	HSPD1	1
GO:0008179	adenylate cyclase binding	1/781	13/18367	0.431679906668781	0.742054413207768	CAP2	1
GO:0008195	phosphatidate phosphatase activity	1/781	13/18367	0.431679906668781	0.742054413207768	PLPP3	1
GO:0015385	sodium:proton antiporter activity	1/781	13/18367	0.431679906668781	0.742054413207768	SLC9A1	1
GO:0016840	carbon-nitrogen lyase activity	1/781	13/18367	0.431679906668781	0.742054413207768	APMAP	1
GO:0022851	GABA-gated chloride ion channel activity	1/781	13/18367	0.431679906668781	0.742054413207768	GABRE	1
GO:0031386	protein tag	1/781	13/18367	0.431679906668781	0.742054413207768	UBC	1
GO:0031994	insulin-like growth factor I binding	1/781	13/18367	0.431679906668781	0.742054413207768	ITGB4	1
GO:0034236	protein kinase A catalytic subunit binding	1/781	13/18367	0.431679906668781	0.742054413207768	EZR	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/781	13/18367	0.431679906668781	0.742054413207768	UBR5	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/781	13/18367	0.431679906668781	0.742054413207768	SYNJ1	1
GO:0070700	BMP receptor binding	1/781	13/18367	0.431679906668781	0.742054413207768	GDF15	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/781	13/18367	0.431679906668781	0.742054413207768	HSD17B1	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/781	13/18367	0.431679906668781	0.742054413207768	SYNJ1	1
GO:0140299	small molecule sensor activity	1/781	13/18367	0.431679906668781	0.742054413207768	EGLN2	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	6/781	124/18367	0.432932857909251	0.742768752351075	EGFR/EPHB4/CRIM1/ERBB3/NRP1/EFEMP1	6
GO:0046332	SMAD binding	4/781	79/18367	0.434563373017991	0.744126856886019	DAB2/CTNNB1/TGFBR3/FERMT2	4
GO:0004497	monooxygenase activity	5/781	102/18367	0.438309791835237	0.747439963320203	CYP19A1/CYP11A1/HMOX1/KMO/CYP2J2	5
GO:0004725	protein tyrosine phosphatase activity	5/781	102/18367	0.438309791835237	0.747439963320203	PTPN21/DUSP5/DUSP9/PTP4A1/DUSP3	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/781	57/18367	0.439026179131709	0.747439963320203	P4HB/PDIA3/TXNL1	3
GO:0019842	vitamin binding	7/781	148/18367	0.44185742366407	0.749671628837188	ALAS1/SLC19A1/OPN3/MTHFS/EGLN2/PDXK/PDXDC1	7
GO:0008238	exopeptidase activity	5/781	103/18367	0.446691073204176	0.749671628837188	TFRC/CPM/MME/GGH/ENPEP	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3/781	58/18367	0.450290463181265	0.749671628837188	GSTA3/GSTA4/SMS	3
GO:0004065	arylsulfatase activity	1/781	14/18367	0.45586308161112	0.749671628837188	STS	1
GO:0005172	vascular endothelial growth factor receptor binding	1/781	14/18367	0.45586308161112	0.749671628837188	PGF	1
GO:0005451	monovalent cation:proton antiporter activity	1/781	14/18367	0.45586308161112	0.749671628837188	SLC9A1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/781	14/18367	0.45586308161112	0.749671628837188	B3GNT5	1
GO:0015373	anion:sodium symporter activity	1/781	14/18367	0.45586308161112	0.749671628837188	SLC13A4	1
GO:0017110	nucleoside-diphosphatase activity	1/781	14/18367	0.45586308161112	0.749671628837188	CANT1	1
GO:0031005	filamin binding	1/781	14/18367	0.45586308161112	0.749671628837188	NEBL	1
GO:0036041	long-chain fatty acid binding	1/781	14/18367	0.45586308161112	0.749671628837188	PPARD	1
GO:0044548	S100 protein binding	1/781	14/18367	0.45586308161112	0.749671628837188	EZR	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/781	14/18367	0.45586308161112	0.749671628837188	HSD17B1	1
GO:0070411	I-SMAD binding	1/781	14/18367	0.45586308161112	0.749671628837188	CTNNB1	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/781	14/18367	0.45586308161112	0.749671628837188	SYNJ1	1
GO:0023023	MHC protein complex binding	2/781	36/18367	0.456403660826575	0.749671628837188	HSP90AA1/HSPA8	2
GO:0043394	proteoglycan binding	2/781	36/18367	0.456403660826575	0.749671628837188	CTSL/LRP1	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	4/781	82/18367	0.463014921744333	0.749671628837188	SCIN/SYT7/SLC9A1/COMMD1	4
GO:0015035	protein-disulfide reductase activity	2/781	37/18367	0.470644514393948	0.749671628837188	P4HB/PDIA3	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/781	37/18367	0.470644514393948	0.749671628837188	FAR2/AKR1B1	2
GO:0042056	chemoattractant activity	2/781	37/18367	0.470644514393948	0.749671628837188	PGF/MIF	2
GO:0046915	transition metal ion transmembrane transporter activity	2/781	37/18367	0.470644514393948	0.749671628837188	SLC40A1/SLC39A7	2
GO:0071949	FAD binding	2/781	37/18367	0.470644514393948	0.749671628837188	KMO/CYB5R1	2
GO:0001846	opsonin binding	1/781	15/18367	0.47901847491258	0.749671628837188	CALR	1
GO:0005161	platelet-derived growth factor receptor binding	1/781	15/18367	0.47901847491258	0.749671628837188	ERN1	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/781	15/18367	0.47901847491258	0.749671628837188	GABRE	1
GO:0008020	G protein-coupled photoreceptor activity	1/781	15/18367	0.47901847491258	0.749671628837188	OPN3	1
GO:0010851	cyclase regulator activity	1/781	15/18367	0.47901847491258	0.749671628837188	GNAS	1
GO:0016846	carbon-sulfur lyase activity	1/781	15/18367	0.47901847491258	0.749671628837188	MGST3	1
GO:0017136	NAD-dependent histone deacetylase activity	1/781	15/18367	0.47901847491258	0.749671628837188	HDAC5	1
GO:0032794	GTPase activating protein binding	1/781	15/18367	0.47901847491258	0.749671628837188	GNAI1	1
GO:0042809	vitamin D receptor binding	1/781	15/18367	0.47901847491258	0.749671628837188	MED13	1
GO:0047372	acylglycerol lipase activity	1/781	15/18367	0.47901847491258	0.749671628837188	ABHD3	1
GO:0048185	activin binding	1/781	15/18367	0.47901847491258	0.749671628837188	TGFBR3	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/781	15/18367	0.47901847491258	0.749671628837188	KMO	1
GO:0051139	metal ion:proton antiporter activity	1/781	15/18367	0.47901847491258	0.749671628837188	SLC9A1	1
GO:0051371	muscle alpha-actinin binding	1/781	15/18367	0.47901847491258	0.749671628837188	PDLIM2	1
GO:1904680	peptide transmembrane transporter activity	1/781	15/18367	0.47901847491258	0.749671628837188	SLC13A3	1
GO:1990825	sequence-specific mRNA binding	1/781	15/18367	0.47901847491258	0.749671628837188	ETF1	1
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/781	38/18367	0.484658918794075	0.749671628837188	FKBP2/PPIB	2
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/781	38/18367	0.484658918794075	0.749671628837188	GTF2B/TAF13	2
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	2/781	38/18367	0.484658918794075	0.749671628837188	REXO2/XRN1	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/781	38/18367	0.484658918794075	0.749671628837188	SIAH1/SIAH2	2
GO:0140303	intramembrane lipid transporter activity	2/781	38/18367	0.484658918794075	0.749671628837188	ATP10D/ABCG1	2
GO:0050660	flavin adenine dinucleotide binding	4/781	85/18367	0.490947009553201	0.749671628837188	KMO/CYB5R1/MAOA/ACADVL	4
GO:1990841	promoter-specific chromatin binding	3/781	62/18367	0.494355551276917	0.749671628837188	ZNF750/FOXO4/GTF2B	3
GO:0004386	helicase activity	7/781	156/18367	0.496914211637077	0.749671628837188	ANXA1/DDX28/DHX36/DDX3X/EIF4A3/CHD2/EIF4A1	7
GO:0004402	histone acetyltransferase activity	2/781	39/18367	0.498440367324826	0.749671628837188	NCOA3/GTF2B	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/781	39/18367	0.498440367324826	0.749671628837188	AK3/MPP1	2
GO:0019825	oxygen binding	2/781	39/18367	0.498440367324826	0.749671628837188	CYP19A1/EGLN2	2
GO:0050997	quaternary ammonium group binding	2/781	39/18367	0.498440367324826	0.749671628837188	PITPNA/CHMP2A	2
GO:0016209	antioxidant activity	4/781	86/18367	0.500124365095352	0.749671628837188	GPX3/MGST3/PRDX6/SOD1	4
GO:0003688	DNA replication origin binding	1/781	16/18367	0.501189713529259	0.749671628837188	HSPD1	1
GO:0004698	calcium-dependent protein kinase C activity	1/781	16/18367	0.501189713529259	0.749671628837188	PRKCZ	1
GO:0005283	amino acid:sodium symporter activity	1/781	16/18367	0.501189713529259	0.749671628837188	SLC38A1	1
GO:0005523	tropomyosin binding	1/781	16/18367	0.501189713529259	0.749671628837188	NEBL	1
GO:0008970	phospholipase A1 activity	1/781	16/18367	0.501189713529259	0.749671628837188	ABHD3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/781	16/18367	0.501189713529259	0.749671628837188	SLC22A11	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/781	16/18367	0.501189713529259	0.749671628837188	SLC13A3	1
GO:0016208	AMP binding	1/781	16/18367	0.501189713529259	0.749671628837188	ACSS1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/781	16/18367	0.501189713529259	0.749671628837188	PIK3C2A	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/781	16/18367	0.501189713529259	0.749671628837188	MAOA	1
GO:0022821	potassium ion antiporter activity	1/781	16/18367	0.501189713529259	0.749671628837188	SLC9A1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/781	16/18367	0.501189713529259	0.749671628837188	HDAC5	1
GO:0035173	histone kinase activity	1/781	16/18367	0.501189713529259	0.749671628837188	CDK2	1
GO:0035497	cAMP response element binding	1/781	16/18367	0.501189713529259	0.749671628837188	CREB3L2	1
GO:0036122	BMP binding	1/781	16/18367	0.501189713529259	0.749671628837188	GREM2	1
GO:0042577	lipid phosphatase activity	1/781	16/18367	0.501189713529259	0.749671628837188	PLPP3	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/781	16/18367	0.501189713529259	0.749671628837188	SOCS1	1
GO:0070492	oligosaccharide binding	1/781	16/18367	0.501189713529259	0.749671628837188	LGALS16	1
GO:0140327	flippase activity	1/781	16/18367	0.501189713529259	0.749671628837188	ATP10D	1
GO:1990404	protein ADP-ribosylase activity	1/781	16/18367	0.501189713529259	0.749671628837188	TNKS2	1
GO:0047485	protein N-terminus binding	5/781	110/18367	0.504300108736313	0.752248824471413	NCOA3/MDM2/HSPA1B/STX5/SRRM2	5
GO:0004532	exoribonuclease activity	2/781	40/18367	0.511983314225712	0.752248824471413	REXO2/XRN1	2
GO:0042169	SH2 domain binding	2/781	40/18367	0.511983314225712	0.752248824471413	SQSTM1/GHR	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/781	40/18367	0.511983314225712	0.752248824471413	SERPINB9/TNFAIP8	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	4/781	88/18367	0.518258514151993	0.752248824471413	KMO/CYB5R1/NDUFA6/NDUFB9	4
GO:0000400	four-way junction DNA binding	1/781	17/18367	0.522418574830203	0.752248824471413	HMGB3	1
GO:0004697	protein kinase C activity	1/781	17/18367	0.522418574830203	0.752248824471413	PRKCZ	1
GO:0005005	transmembrane-ephrin receptor activity	1/781	17/18367	0.522418574830203	0.752248824471413	EPHB4	1
GO:0005324	long-chain fatty acid transporter activity	1/781	17/18367	0.522418574830203	0.752248824471413	SLC2A1	1
GO:0008308	voltage-gated anion channel activity	1/781	17/18367	0.522418574830203	0.752248824471413	CLCN3	1
GO:0008381	mechanosensitive ion channel activity	1/781	17/18367	0.522418574830203	0.752248824471413	TMEM150C	1
GO:0008392	arachidonic acid epoxygenase activity	1/781	17/18367	0.522418574830203	0.752248824471413	CYP2J2	1
GO:0009881	photoreceptor activity	1/781	17/18367	0.522418574830203	0.752248824471413	OPN3	1
GO:0015108	chloride transmembrane transporter activity	1/781	17/18367	0.522418574830203	0.752248824471413	SLC26A2	1
GO:0015377	cation:chloride symporter activity	1/781	17/18367	0.522418574830203	0.752248824471413	SLC12A4	1
GO:0016854	racemase and epimerase activity	1/781	17/18367	0.522418574830203	0.752248824471413	GLCE	1
GO:0017081	chloride channel regulator activity	1/781	17/18367	0.522418574830203	0.752248824471413	SGK1	1
GO:0031420	alkali metal ion binding	1/781	17/18367	0.522418574830203	0.752248824471413	PDXK	1
GO:0031489	myosin V binding	1/781	17/18367	0.522418574830203	0.752248824471413	RAB11A	1
GO:0042800	histone methyltransferase activity (H3-K4 specific)	1/781	17/18367	0.522418574830203	0.752248824471413	KMT2C	1
GO:0043395	heparan sulfate proteoglycan binding	1/781	17/18367	0.522418574830203	0.752248824471413	LRP1	1
GO:0046965	retinoid X receptor binding	1/781	17/18367	0.522418574830203	0.752248824471413	TACC1	1
GO:0052745	inositol phosphate phosphatase activity	1/781	17/18367	0.522418574830203	0.752248824471413	SYNJ1	1
GO:0016859	cis-trans isomerase activity	2/781	41/18367	0.525283104906787	0.752707777144298	FKBP2/PPIB	2
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/781	41/18367	0.525283104906787	0.752707777144298	ACSS1/UBA5	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/781	41/18367	0.525283104906787	0.752707777144298	NCOA3/GTF2B	2
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2/781	42/18367	0.538335910361216	0.760529024612453	NDUFA6/NDUFB9	2
GO:0008307	structural constituent of muscle	2/781	42/18367	0.538335910361216	0.760529024612453	TPM4/NEBL	2
GO:0019205	nucleobase-containing compound kinase activity	2/781	42/18367	0.538335910361216	0.760529024612453	AK3/MPP1	2
GO:0019894	kinesin binding	2/781	42/18367	0.538335910361216	0.760529024612453	SPAG9/PLEKHM2	2
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/781	18/18367	0.542745064915087	0.760529024612453	HSD17B1	1
GO:0004708	MAP kinase kinase activity	1/781	18/18367	0.542745064915087	0.760529024612453	BRAF	1
GO:0008301	DNA binding, bending	1/781	18/18367	0.542745064915087	0.760529024612453	HMGB3	1
GO:0008409	5'-3' exonuclease activity	1/781	18/18367	0.542745064915087	0.760529024612453	XRN1	1
GO:0016755	aminoacyltransferase activity	1/781	18/18367	0.542745064915087	0.760529024612453	TGM2	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/781	18/18367	0.542745064915087	0.760529024612453	AKR1B1	1
GO:0048038	quinone binding	1/781	18/18367	0.542745064915087	0.760529024612453	COQ10B	1
GO:0098918	structural constituent of synapse	1/781	18/18367	0.542745064915087	0.760529024612453	ERC1	1
GO:0099095	ligand-gated anion channel activity	1/781	18/18367	0.542745064915087	0.760529024612453	GABRE	1
GO:0140597	protein carrier activity	1/781	18/18367	0.542745064915087	0.760529024612453	HSPA8	1
GO:0020037	heme binding	6/781	139/18367	0.543626767591385	0.760563001346306	CYP19A1/CYP11A1/HMOX1/PGRMC2/CYP2J2/EIF2AK1	6
GO:0032266	phosphatidylinositol-3-phosphate binding	2/781	43/18367	0.551138665532603	0.76864779296764	ATG2A/SNX27	2
GO:0050136	NADH dehydrogenase (quinone) activity	2/781	43/18367	0.551138665532603	0.76864779296764	NDUFA6/NDUFB9	2
GO:0008080	N-acetyltransferase activity	3/781	68/18367	0.55693735638653	0.774300055038953	NCOA3/SAT1/GTF2B	3
GO:0019843	rRNA binding	3/781	68/18367	0.55693735638653	0.774300055038953	SBDS/DDX28/MDM2	3
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/781	19/18367	0.562207493619721	0.775181632759008	TGFBR3	1
GO:0004745	NAD-retinol dehydrogenase activity	1/781	19/18367	0.562207493619721	0.775181632759008	RDH10	1
GO:0004890	GABA-A receptor activity	1/781	19/18367	0.562207493619721	0.775181632759008	GABRE	1
GO:0005003	ephrin receptor activity	1/781	19/18367	0.562207493619721	0.775181632759008	EPHB4	1
GO:0016918	retinal binding	1/781	19/18367	0.562207493619721	0.775181632759008	OPN3	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	2/781	44/18367	0.563689011420022	0.775181632759008	SGK1/BRAF	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/781	44/18367	0.563689011420022	0.775181632759008	FAR2/AKR1B1	2
GO:0004197	cysteine-type endopeptidase activity	5/781	119/18367	0.574576629974024	0.775914666584129	CTSL/PDIA3/USP8/USP16/USP47	5
GO:0003954	NADH dehydrogenase activity	2/781	45/18367	0.575985240714951	0.775914666584129	NDUFA6/NDUFB9	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	2/781	45/18367	0.575985240714951	0.775914666584129	NDUFA6/NDUFB9	2
GO:0048156	tau protein binding	2/781	45/18367	0.575985240714951	0.775914666584129	HSP90AA1/TAOK1	2
GO:0140223	general transcription initiation factor activity	2/781	45/18367	0.575985240714951	0.775914666584129	GTF2B/TAF13	2
GO:0016798	hydrolase activity, acting on glycosyl bonds	6/781	144/18367	0.578423220622834	0.775914666584129	MAN1A2/NEU1/EDEM1/FUCA1/MAN1C1/GLA	6
GO:0140375	immune receptor activity	6/781	144/18367	0.578423220622834	0.775914666584129	CSF3R/GHR/IL10RB/LIFR/PRLR/CSF2RA	6
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/781	20/18367	0.580842546349337	0.775914666584129	EDF1	1
GO:0016018	cyclosporin A binding	1/781	20/18367	0.580842546349337	0.775914666584129	PPIB	1
GO:0016408	C-acyltransferase activity	1/781	20/18367	0.580842546349337	0.775914666584129	SPTSSA	1
GO:0016500	protein-hormone receptor activity	1/781	20/18367	0.580842546349337	0.775914666584129	LGR4	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/781	20/18367	0.580842546349337	0.775914666584129	MAOA	1
GO:0030296	protein tyrosine kinase activator activity	1/781	20/18367	0.580842546349337	0.775914666584129	ERBB3	1
GO:0031418	L-ascorbic acid binding	1/781	20/18367	0.580842546349337	0.775914666584129	EGLN2	1
GO:0031681	G-protein beta-subunit binding	1/781	20/18367	0.580842546349337	0.775914666584129	GNG12	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/781	20/18367	0.580842546349337	0.775914666584129	SOCS1	1
GO:0042288	MHC class I protein binding	1/781	20/18367	0.580842546349337	0.775914666584129	VCP	1
GO:0050145	nucleoside monophosphate kinase activity	1/781	20/18367	0.580842546349337	0.775914666584129	MPP1	1
GO:0070300	phosphatidic acid binding	1/781	20/18367	0.580842546349337	0.775914666584129	COMMD1	1
GO:0031491	nucleosome binding	3/781	71/18367	0.586430601807027	0.78220141925238	MBD3/MLLT6/SUPT6H	3
GO:0061980	regulatory RNA binding	2/781	46/18367	0.588026246775029	0.783152073407584	NEAT1/AGO2	2
GO:0008235	metalloexopeptidase activity	3/781	72/18367	0.595978112847879	0.786716900739123	TFRC/CPM/ENPEP	3
GO:0052689	carboxylic ester hydrolase activity	6/781	147/18367	0.598647252247297	0.786716900739123	APMAP/ABHD5/ABHD3/PNPLA8/PNPLA2/PRDX6	6
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/781	21/18367	0.598685352873628	0.786716900739123	ABHD5	1
GO:0004407	histone deacetylase activity	1/781	21/18367	0.598685352873628	0.786716900739123	HDAC5	1
GO:0005123	death receptor binding	1/781	21/18367	0.598685352873628	0.786716900739123	TMBIM1	1
GO:0005385	zinc ion transmembrane transporter activity	1/781	21/18367	0.598685352873628	0.786716900739123	SLC39A7	1
GO:0008373	sialyltransferase activity	1/781	21/18367	0.598685352873628	0.786716900739123	ST3GAL4	1
GO:0008391	arachidonic acid monooxygenase activity	1/781	21/18367	0.598685352873628	0.786716900739123	CYP2J2	1
GO:0051428	peptide hormone receptor binding	1/781	21/18367	0.598685352873628	0.786716900739123	GNAS	1
GO:0005044	scavenger receptor activity	2/781	47/18367	0.599811475749759	0.787030738150941	LRP1/COLEC12	2
GO:0046906	tetrapyrrole binding	6/781	149/18367	0.611837073014526	0.79619182754948	CYP19A1/CYP11A1/HMOX1/PGRMC2/CYP2J2/EIF2AK1	6
GO:0004721	phosphoprotein phosphatase activity	7/781	174/18367	0.61304266989158	0.79619182754948	PTPN21/DUSP5/DUSP9/PTP4A1/DUSP3/PHLPP1/PPP1CB	7
GO:0005416	amino acid:cation symporter activity	1/781	22/18367	0.615769553211887	0.79619182754948	SLC38A1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/781	22/18367	0.615769553211887	0.79619182754948	SLC26A2	1
GO:0016917	GABA receptor activity	1/781	22/18367	0.615769553211887	0.79619182754948	GABRE	1
GO:0017075	syntaxin-1 binding	1/781	22/18367	0.615769553211887	0.79619182754948	STXBP3	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/781	22/18367	0.615769553211887	0.79619182754948	TUFT1	1
GO:0033558	protein deacetylase activity	1/781	22/18367	0.615769553211887	0.79619182754948	HDAC5	1
GO:0033691	sialic acid binding	1/781	22/18367	0.615769553211887	0.79619182754948	SIGLEC6	1
GO:0070182	DNA polymerase binding	1/781	22/18367	0.615769553211887	0.79619182754948	HSP90AA1	1
GO:0016763	pentosyltransferase activity	2/781	49/18367	0.622614884425287	0.802702619891322	PNP/TNKS2	2
GO:0034212	peptide N-acetyltransferase activity	2/781	49/18367	0.622614884425287	0.802702619891322	NCOA3/GTF2B	2
GO:0016791	phosphatase activity	11/781	275/18367	0.625303590702098	0.80329078648791	PTPN21/DUSP5/MTMR10/DUSP9/PLPP3/PHOSPHO1/PTP4A1/DUSP3/SYNJ1/PHLPP1/PPP1CB	11
GO:0030295	protein kinase activator activity	4/781	101/18367	0.6276029784499	0.80329078648791	ERBB3/DDX3X/RICTOR/TAOK1	4
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/781	23/18367	0.632127360731185	0.80329078648791	TNKS2	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/781	23/18367	0.632127360731185	0.80329078648791	PRKCZ	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/781	23/18367	0.632127360731185	0.80329078648791	CDO1	1
GO:0017134	fibroblast growth factor binding	1/781	23/18367	0.632127360731185	0.80329078648791	TGFBR3	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/781	23/18367	0.632127360731185	0.80329078648791	ABHD5	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/781	23/18367	0.632127360731185	0.80329078648791	SQSTM1	1
GO:0071617	lysophospholipid acyltransferase activity	1/781	23/18367	0.632127360731185	0.80329078648791	ABHD5	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/781	23/18367	0.632127360731185	0.80329078648791	C1GALT1	1
GO:0031490	chromatin DNA binding	4/781	103/18367	0.642950974712688	0.81271484473029	TOX4/GRHL1/MBD3/ACTN4	4
GO:0001965	G-protein alpha-subunit binding	1/781	24/18367	0.647789622575327	0.81271484473029	NUCB2	1
GO:0004622	lysophospholipase activity	1/781	24/18367	0.647789622575327	0.81271484473029	PNPLA8	1
GO:0008171	O-methyltransferase activity	1/781	24/18367	0.647789622575327	0.81271484473029	PCMTD1	1
GO:0010857	calcium-dependent protein kinase activity	1/781	24/18367	0.647789622575327	0.81271484473029	PRKCZ	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/781	24/18367	0.647789622575327	0.81271484473029	CDO1	1
GO:0050431	transforming growth factor beta binding	1/781	24/18367	0.647789622575327	0.81271484473029	TGFBR3	1
GO:0051537	2 iron, 2 sulfur cluster binding	1/781	24/18367	0.647789622575327	0.81271484473029	FDX1	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/781	24/18367	0.647789622575327	0.81271484473029	GDF15	1
GO:0046873	metal ion transmembrane transporter activity	17/781	430/18367	0.656261737509353	0.822181018602819	SLC40A1/SLC13A4/SLC3A2/SLC38A1/KCNN4/SLC6A8/ANXA6/CNNM2/SLC5A6/TUSC3/SLC39A7/TMEM37/SLC12A4/SLC9A1/KCNG1/SLC20A1/SLC13A3	17
GO:0005112	Notch binding	1/781	25/18367	0.662785877537365	0.825689709797251	AAK1	1
GO:0005227	calcium activated cation channel activity	1/781	25/18367	0.662785877537365	0.825689709797251	KCNN4	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	1/781	25/18367	0.662785877537365	0.825689709797251	DHX36	1
GO:0070330	aromatase activity	1/781	25/18367	0.662785877537365	0.825689709797251	CYP19A1	1
GO:0050661	NADP binding	2/781	53/18367	0.665179424461623	0.826350349436218	HSD17B1/HIBADH	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/781	53/18367	0.665179424461623	0.826350349436218	ABCG1/SLC16A3	2
GO:0019209	kinase activator activity	4/781	107/18367	0.672378255270904	0.832960212884485	ERBB3/DDX3X/RICTOR/TAOK1	4
GO:1902936	phosphatidylinositol bisphosphate binding	4/781	107/18367	0.672378255270904	0.832960212884485	SCIN/SYT7/SLC9A1/COMMD1	4
GO:0004435	phosphatidylinositol phospholipase C activity	1/781	26/18367	0.677144411483681	0.834204295813923	GDPD5	1
GO:0004806	triglyceride lipase activity	1/781	26/18367	0.677144411483681	0.834204295813923	PNPLA2	1
GO:0038187	pattern recognition receptor activity	1/781	26/18367	0.677144411483681	0.834204295813923	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/781	26/18367	0.677144411483681	0.834204295813923	SLC26A2	1
GO:0004190	aspartic-type endopeptidase activity	1/781	27/18367	0.690892310433097	0.844106720873494	BACE2	1
GO:0016405	CoA-ligase activity	1/781	27/18367	0.690892310433097	0.844106720873494	ACSS1	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/781	27/18367	0.690892310433097	0.844106720873494	SYNJ1	1
GO:0043425	bHLH transcription factor binding	1/781	27/18367	0.690892310433097	0.844106720873494	BHLHE40	1
GO:0051393	alpha-actinin binding	1/781	27/18367	0.690892310433097	0.844106720873494	PDLIM2	1
GO:0070006	metalloaminopeptidase activity	1/781	27/18367	0.690892310433097	0.844106720873494	ENPEP	1
GO:0051287	NAD binding	2/781	56/18367	0.694497594398797	0.84734438271215	HSD11B2/HIBADH	2
GO:0042578	phosphoric ester hydrolase activity	14/781	366/18367	0.695668276622553	0.84760681506072	HMOX1/PTPN21/DUSP5/MTMR10/DUSP9/PLPP3/PHOSPHO1/GDPD5/PTP4A1/DUSP3/PDIA3/SYNJ1/PHLPP1/PPP1CB	14
GO:0001540	amyloid-beta binding	3/781	84/18367	0.698991678383891	0.850487817183143	LRPAP1/LDLR/LRP1	3
GO:0008094	ATP-dependent activity, acting on DNA	4/781	111/18367	0.700088005402103	0.850654877796802	ANXA1/DHX36/DDX3X/CHD2	4
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	2/781	57/18367	0.703787464044873	0.85081367657089	NDUFA6/NDUFB9	2
GO:0050681	androgen receptor binding	1/781	28/18367	0.704055511390117	0.85081367657089	CALR	1
GO:0070001	aspartic-type peptidase activity	1/781	28/18367	0.704055511390117	0.85081367657089	BACE2	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/781	28/18367	0.704055511390117	0.85081367657089	COMMD1	1
GO:0016874	ligase activity	6/781	165/18367	0.708068669134078	0.854403764598279	RIMKLB/ACSS1/MTHFS/MDM2/ASNSD1/UBA5	6
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/781	58/18367	0.71284092836143	0.854403764598279	SLC5A6/SLC16A3	2
GO:0001664	G protein-coupled receptor binding	11/781	295/18367	0.714313096417622	0.854403764598279	NPB/ARRDC3/GNA12/GNAI1/GNAS/DVL3/ITGB4/HSPA1B/DNAJA1/ADM/HSPA8	11
GO:0004181	metallocarboxypeptidase activity	1/781	29/18367	0.716658851027192	0.854403764598279	CPM	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/781	29/18367	0.716658851027192	0.854403764598279	AKR1B1	1
GO:0032452	histone demethylase activity	1/781	29/18367	0.716658851027192	0.854403764598279	KDM5B	1
GO:0035250	UDP-galactosyltransferase activity	1/781	29/18367	0.716658851027192	0.854403764598279	B3GNT5	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/781	29/18367	0.716658851027192	0.854403764598279	COMMD1	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/781	29/18367	0.716658851027192	0.854403764598279	OSBP	1
GO:0140457	protein demethylase activity	1/781	29/18367	0.716658851027192	0.854403764598279	KDM5B	1
GO:0003774	cytoskeletal motor activity	4/781	114/18367	0.719736891834575	0.85576645423374	MYO10/APPBP2/MYO6/KIF21A	4
GO:0005126	cytokine receptor binding	10/781	271/18367	0.720696213430218	0.85576645423374	PGF/GATA3/LIFR/DDT/PRLR/TMBIM1/SNX6/MIF/TGFBR3/FERMT2	10
GO:0030246	carbohydrate binding	10/781	271/18367	0.720696213430218	0.85576645423374	LGALS16/SIGLEC6/OLR1/LMAN2/EGLN2/LGALS8/BSG/CALR/COLEC12/SLC2A8	10
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/781	59/18367	0.721661266273296	0.85576676896312	REXO2/XRN1	2
GO:0051219	phosphoprotein binding	3/781	88/18367	0.72855081314727	0.861840082154991	RASA1/TBK1/PAFAH1B1	3
GO:0070566	adenylyltransferase activity	1/781	30/18367	0.728726112306926	0.861840082154991	PAPOLA	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/781	60/18367	0.730251905462655	0.862494594068409	AKR1B1/ACADVL	2
GO:0004540	ribonuclease activity	4/781	116/18367	0.732298243550806	0.863199420330787	ERN1/REXO2/XRN1/AGO2	4
GO:0016829	lyase activity	7/781	196/18367	0.732794998319146	0.863199420330787	CDYL/APMAP/MGST3/DDT/PDXDC1/ACO2/AZIN1	7
GO:0008081	phosphoric diester hydrolase activity	3/781	89/18367	0.735574361948441	0.864178091454659	HMOX1/GDPD5/PDIA3	3
GO:0043178	alcohol binding	3/781	89/18367	0.735574361948441	0.864178091454659	ANXA6/GRAMD1C/ABCG1	3
GO:0005085	guanyl-nucleotide exchange factor activity	8/781	223/18367	0.736702549167115	0.864358678718559	NUCB2/EPS8L1/VAV3/FGD6/ARF4/RAPGEF1/FNIP1/EIF2B2	8
GO:0008157	protein phosphatase 1 binding	1/781	31/18367	0.740280069131286	0.865123084742359	STAU1	1
GO:0016878	acid-thiol ligase activity	1/781	31/18367	0.740280069131286	0.865123084742359	ACSS1	1
GO:0043015	gamma-tubulin binding	1/781	31/18367	0.740280069131286	0.865123084742359	DDX3X	1
GO:0004175	endopeptidase activity	16/781	430/18367	0.743420788918756	0.867650315488074	BACE2/CTSL/MME/FURIN/PSMB1/PRSS8/SEC11C/PDIA3/PSMB4/TMEM59/USP8/USP16/USP47/PSMB5/PSMB6/ADAMTS6	16
GO:0005201	extracellular matrix structural constituent	6/781	172/18367	0.744655902355316	0.867761488688503	FBLN1/TINAGL1/VWA1/LAMC2/TUFT1/EFEMP1	6
GO:0016407	acetyltransferase activity	3/781	91/18367	0.749189586528374	0.867761488688503	NCOA3/SAT1/GTF2B	3
GO:0001222	transcription corepressor binding	1/781	32/18367	0.751342529101207	0.867761488688503	LCOR	1
GO:0030332	cyclin binding	1/781	32/18367	0.751342529101207	0.867761488688503	CDK2	1
GO:0048019	receptor antagonist activity	1/781	32/18367	0.751342529101207	0.867761488688503	LRPAP1	1
GO:0050699	WW domain binding	1/781	32/18367	0.751342529101207	0.867761488688503	PRRG4	1
GO:0051721	protein phosphatase 2A binding	1/781	32/18367	0.751342529101207	0.867761488688503	BCL2	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/781	32/18367	0.751342529101207	0.867761488688503	CHD2	1
GO:0005251	delayed rectifier potassium channel activity	1/781	33/18367	0.761934374466462	0.877094859200283	KCNG1	1
GO:0051427	hormone receptor binding	1/781	33/18367	0.761934374466462	0.877094859200283	GNAS	1
GO:0016836	hydro-lyase activity	2/781	64/18367	0.762390232743425	0.877094859200283	CDYL/ACO2	2
GO:0031406	carboxylic acid binding	6/781	176/18367	0.764025598782314	0.877837702227866	SLC19A1/UBR1/SIGLEC6/MTHFS/PPARD/EGLN2	6
GO:0030145	manganese ion binding	2/781	65/18367	0.769887773086534	0.881378453527187	ARG2/PAPOLA	2
GO:0008376	acetylgalactosaminyltransferase activity	1/781	34/18367	0.772075601342305	0.881378453527187	CHPF	1
GO:0015020	glucuronosyltransferase activity	1/781	34/18367	0.772075601342305	0.881378453527187	CHPF	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/781	34/18367	0.772075601342305	0.881378453527187	AGO2	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/781	34/18367	0.772075601342305	0.881378453527187	IRS2	1
GO:0000175	3'-5'-exoribonuclease activity	1/781	35/18367	0.781785357266139	0.891315696523221	REXO2	1
GO:0000217	DNA secondary structure binding	1/781	36/18367	0.791081977164412	0.896237870703337	HMGB3	1
GO:0042605	peptide antigen binding	1/781	36/18367	0.791081977164412	0.896237870703337	SLC7A5	1
GO:0042805	actinin binding	1/781	36/18367	0.791081977164412	0.896237870703337	PDLIM2	1
GO:0051536	iron-sulfur cluster binding	2/781	68/18367	0.791154738174423	0.896237870703337	FDX1/ACO2	2
GO:0051540	metal cluster binding	2/781	68/18367	0.791154738174423	0.896237870703337	FDX1/ACO2	2
GO:0003777	microtubule motor activity	2/781	69/18367	0.79784866652533	0.90048849845923	APPBP2/KIF21A	2
GO:0004521	endoribonuclease activity	2/781	69/18367	0.79784866652533	0.90048849845923	ERN1/AGO2	2
GO:0005109	frizzled binding	1/781	37/18367	0.799983017796925	0.90048849845923	DVL3	1
GO:0030551	cyclic nucleotide binding	1/781	37/18367	0.799983017796925	0.90048849845923	SLC19A1	1
GO:0071855	neuropeptide receptor binding	1/781	37/18367	0.799983017796925	0.90048849845923	GNAS	1
GO:0005501	retinoid binding	1/781	38/18367	0.808505290742948	0.906629826661182	OPN3	1
GO:0019213	deacetylase activity	1/781	38/18367	0.808505290742948	0.906629826661182	HDAC5	1
GO:0019840	isoprenoid binding	1/781	38/18367	0.808505290742948	0.906629826661182	OPN3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/781	71/18367	0.810668422093842	0.907907689895503	TGM2/HDAC5	2
GO:0005504	fatty acid binding	1/781	39/18367	0.816664893990794	0.912319598198783	PPARD	1
GO:0032451	demethylase activity	1/781	39/18367	0.816664893990794	0.912319598198783	KDM5B	1
GO:0035064	methylated histone binding	2/781	73/18367	0.822757969856057	0.912997894909413	CDYL/MORC4	2
GO:0140034	methylation-dependent protein binding	2/781	73/18367	0.822757969856057	0.912997894909413	CDYL/MORC4	2
GO:0008237	metallopeptidase activity	6/781	190/18367	0.823235067488044	0.912997894909413	TFRC/CPM/MME/ENPEP/PSMD14/ADAMTS6	6
GO:0019787	ubiquitin-like protein transferase activity	16/781	458/18367	0.823533973872607	0.912997894909413	SIAH1/UBE2B/MYLIP/NEDD4L/SIAH2/UBE2A/UBR1/HECTD1/MIB1/UBR5/RNF11/MDM2/UBE2M/UBE2H/RBBP6/UBE2I	16
GO:0004177	aminopeptidase activity	1/781	40/18367	0.824477242189898	0.912997894909413	ENPEP	1
GO:0031492	nucleosomal DNA binding	1/781	40/18367	0.824477242189898	0.912997894909413	MBD3	1
GO:0042287	MHC protein binding	1/781	40/18367	0.824477242189898	0.912997894909413	VCP	1
GO:0004842	ubiquitin-protein transferase activity	15/781	433/18367	0.826470755213427	0.914064289120087	SIAH1/UBE2B/MYLIP/NEDD4L/SIAH2/UBE2A/UBR1/HECTD1/MIB1/UBR5/RNF11/MDM2/UBE2M/UBE2H/RBBP6	15
GO:0017022	myosin binding	2/781	74/18367	0.828539102022855	0.914933316429489	RAB11A/VEZT	2
GO:1990782	protein tyrosine kinase binding	3/781	105/18367	0.829319488623798	0.914933316429489	SQSTM1/DUSP3/HSP90AA1	3
GO:0043177	organic acid binding	4/781	135/18367	0.831093027379455	0.915750950665313	SLC19A1/MTHFS/PPARD/EGLN2	4
GO:0061630	ubiquitin protein ligase activity	10/781	304/18367	0.837215499492975	0.921161123152943	SIAH1/MYLIP/NEDD4L/SIAH2/UBR1/HECTD1/UBR5/RNF11/MDM2/RBBP6	10
GO:0019208	phosphatase regulator activity	3/781	107/18367	0.838765260981924	0.921161123152943	PPP1R12B/PPP1R10/PPP4R2	3
GO:0051539	4 iron, 4 sulfur cluster binding	1/781	42/18367	0.839118587945409	0.921161123152943	ACO2	1
GO:0004180	carboxypeptidase activity	1/781	43/18367	0.845975252764762	0.922976690285786	CPM	1
GO:0005246	calcium channel regulator activity	1/781	43/18367	0.845975252764762	0.922976690285786	SGK1	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/781	43/18367	0.845975252764762	0.922976690285786	KMO	1
GO:0018024	histone-lysine N-methyltransferase activity	1/781	43/18367	0.845975252764762	0.922976690285786	KMT2C	1
GO:0030547	signaling receptor inhibitor activity	1/781	43/18367	0.845975252764762	0.922976690285786	LRPAP1	1
GO:0030971	receptor tyrosine kinase binding	2/781	78/18367	0.849999931430694	0.923324815054478	SQSTM1/DUSP3	2
GO:0001784	phosphotyrosine residue binding	1/781	44/18367	0.852540049075105	0.923324815054478	RASA1	1
GO:0008375	acetylglucosaminyltransferase activity	1/781	44/18367	0.852540049075105	0.923324815054478	B3GNT5	1
GO:0022839	ion gated channel activity	1/781	44/18367	0.852540049075105	0.923324815054478	KCNN4	1
GO:0051879	Hsp90 protein binding	1/781	44/18367	0.852540049075105	0.923324815054478	ERN1	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/781	44/18367	0.852540049075105	0.923324815054478	GABRE	1
GO:0016835	carbon-oxygen lyase activity	2/781	79/18367	0.854969013095922	0.924826237336686	CDYL/ACO2	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/781	45/18367	0.858825385628745	0.927775479679629	AGO2	1
GO:0004527	exonuclease activity	2/781	80/18367	0.859787423107841	0.927775479679629	REXO2/XRN1	2
GO:0004864	protein phosphatase inhibitor activity	1/781	46/18367	0.864843144269938	0.932097046132971	PPP1R10	1
GO:0061659	ubiquitin-like protein ligase activity	10/781	316/18367	0.868823704661462	0.93525075975087	SIAH1/MYLIP/NEDD4L/SIAH2/UBR1/HECTD1/UBR5/RNF11/MDM2/RBBP6	10
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/781	47/18367	0.870604702281246	0.936031964755716	GABRE	1
GO:0019212	phosphatase inhibitor activity	1/781	49/18367	0.881402330228299	0.945349294936519	PPP1R10	1
GO:0032813	tumor necrosis factor receptor superfamily binding	1/781	49/18367	0.881402330228299	0.945349294936519	TMBIM1	1
GO:0140359	ABC-type transporter activity	1/781	50/18367	0.886458820024767	0.94962436396373	ABCG1	1
GO:0008276	protein methyltransferase activity	2/781	88/18367	0.89335626698118	0.955858876733783	KMT2C/PCMTD1	2
GO:0005179	hormone activity	3/781	122/18367	0.896204268592884	0.95742997449685	CGA/INSL4/ADM	3
GO:0019888	protein phosphatase regulator activity	2/781	89/18367	0.896983437211818	0.95742997449685	PPP1R10/PPP4R2	2
GO:0015079	potassium ion transmembrane transporter activity	4/781	155/18367	0.900269680718567	0.95874008837411	KCNN4/SLC12A4/SLC9A1/KCNG1	4
GO:0017069	snRNA binding	1/781	53/18367	0.900372597086396	0.95874008837411	HEXIM1	1
GO:0008408	3'-5' exonuclease activity	1/781	54/18367	0.904621204800469	0.961575942196987	REXO2	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/781	125/18367	0.905203959114412	0.961575942196987	ARG2/TGM2/HDAC5	3
GO:0042054	histone methyltransferase activity	1/781	56/18367	0.912583239385074	0.967098367185855	KMT2C	1
GO:0045309	protein phosphorylated amino acid binding	1/781	56/18367	0.912583239385074	0.967098367185855	RASA1	1
GO:0008083	growth factor activity	4/781	162/18367	0.917783545352677	0.971448692992631	GDF15/PGF/MANF/EFEMP1	4
GO:0008170	N-methyltransferase activity	2/781	97/18367	0.922118200424399	0.974873472915902	KMT2C/RNMT	2
GO:0016279	protein-lysine N-methyltransferase activity	1/781	59/18367	0.923298987143527	0.974932920273301	KMT2C	1
GO:0016278	lysine N-methyltransferase activity	1/781	60/18367	0.926570971578796	0.974932920273301	KMT2C	1
GO:0022824	transmitter-gated ion channel activity	1/781	60/18367	0.926570971578796	0.974932920273301	GABRE	1
GO:0022835	transmitter-gated channel activity	1/781	60/18367	0.926570971578796	0.974932920273301	GABRE	1
GO:0043621	protein self-association	1/781	61/18367	0.92970354770798	0.976567957390475	SLC2A1	1
GO:0015085	calcium ion transmembrane transporter activity	3/781	135/18367	0.930326859069844	0.976567957390475	SLC3A2/ANXA6/TMEM37	3
GO:0098960	postsynaptic neurotransmitter receptor activity	1/781	62/18367	0.932702647961452	0.976974493524195	GABRE	1
GO:0003730	mRNA 3'-UTR binding	5/781	201/18367	0.932917019182631	0.976974493524195	SECISBP2L/CPEB4/DHX36/RBMS1/LARP4B	5
GO:0005200	structural constituent of cytoskeleton	2/781	103/18367	0.937050073465794	0.980145536750188	DSP/EPB41L3	2
GO:0008173	RNA methyltransferase activity	1/781	65/18367	0.940954699430671	0.983070457473505	RNMT	1
GO:0016757	glycosyltransferase activity	7/781	270/18367	0.944219150444845	0.985320454640679	ST3GAL4/B3GNT5/C1GALT1/PNP/TNKS2/CHPF/RPN2	7
GO:0003684	damaged DNA binding	1/781	68/18367	0.948196013678589	0.988307713434675	DDB1	1
GO:0004222	metalloendopeptidase activity	2/781	111/18367	0.952777125701234	0.991917031099759	MME/ADAMTS6	2
GO:0005230	extracellular ligand-gated ion channel activity	1/781	73/18367	0.958347754291183	0.995379927466369	GABRE	1
GO:0033293	monocarboxylic acid binding	1/781	73/18367	0.958347754291183	0.995379927466369	PPARD	1
GO:0030546	signaling receptor activator activity	14/781	495/18367	0.962605486097605	0.998478060747982	CGA/GDF15/INSL4/PGF/SEMA6A/GREM2/APP/SEMA7A/LRPAP1/MIF/MANF/CMTM8/ADM/EFEMP1	14
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	3/781	156/18367	0.964390777996603	0.998478060747982	KMT2C/PCMTD1/RNMT	3
GO:0005262	calcium channel activity	2/781	119/18367	0.964707664104871	0.998478060747982	ANXA6/TMEM37	2
GO:0005267	potassium channel activity	2/781	121/18367	0.967203417153964	0.999260971123265	KCNN4/KCNG1	2
GO:0140097	catalytic activity, acting on DNA	5/781	229/18367	0.968803380292437	0.999260971123265	ANXA1/TOP1/DHX36/DDX3X/CHD2	5
GO:0140098	catalytic activity, acting on RNA	10/781	386/18367	0.968843782599784	0.999260971123265	ERN1/DDX28/DHX36/REXO2/XRN1/DDX3X/EIF4A3/AGO2/RNMT/EIF4A1	10
GO:0016758	hexosyltransferase activity	4/781	197/18367	0.970396076110065	0.999567453694048	B3GNT5/C1GALT1/CHPF/RPN2	4
GO:0005244	voltage-gated ion channel activity	4/781	201/18367	0.973794044596743	0.999567453694048	CLIC3/CLCN3/TMEM37/KCNG1	4
GO:0022832	voltage-gated channel activity	4/781	201/18367	0.973794044596743	0.999567453694048	CLIC3/CLCN3/TMEM37/KCNG1	4
GO:0004519	endonuclease activity	2/781	129/18367	0.975590535024002	0.999567453694048	ERN1/AGO2	2
GO:0048018	receptor ligand activity	13/781	487/18367	0.975680861284062	0.999567453694048	CGA/GDF15/INSL4/PGF/SEMA6A/GREM2/SEMA7A/LRPAP1/MIF/MANF/CMTM8/ADM/EFEMP1	13
GO:0016779	nucleotidyltransferase activity	2/781	132/18367	0.978166663262592	0.999567453694048	PAPOLA/CMAS	2
GO:0022836	gated channel activity	8/781	340/18367	0.978537139744485	0.999567453694048	CLIC3/KCNN4/ANXA6/GABRE/TMEM150C/CLCN3/TMEM37/KCNG1	8
GO:0004518	nuclease activity	4/781	210/18367	0.980148720581997	0.999567453694048	ERN1/REXO2/XRN1/AGO2	4
GO:0005249	voltage-gated potassium channel activity	1/781	90/18367	0.980167558045966	0.999567453694048	KCNG1	1
GO:0004252	serine-type endopeptidase activity	3/781	174/18367	0.9804100165883	0.999567453694048	FURIN/PRSS8/SEC11C	3
GO:0008194	UDP-glycosyltransferase activity	2/781	143/18367	0.98554303432408	0.999707217598881	B3GNT5/CHPF	2
GO:0015276	ligand-gated ion channel activity	2/781	143/18367	0.98554303432408	0.999707217598881	ANXA6/GABRE	2
GO:0022834	ligand-gated channel activity	2/781	143/18367	0.98554303432408	0.999707217598881	ANXA6/GABRE	2
GO:0008236	serine-type peptidase activity	3/781	191/18367	0.989032408677013	0.999707217598881	FURIN/PRSS8/SEC11C	3
GO:0005216	ion channel activity	10/781	432/18367	0.989467868041054	0.999707217598881	FXYD3/CLIC3/KCNN4/ANXA6/GABRE/TMEM150C/CLCN3/TMEM37/KCNG1/CLDN4	10
GO:0017171	serine hydrolase activity	3/781	195/18367	0.990450471258334	0.999707217598881	FURIN/PRSS8/SEC11C	3
GO:0005125	cytokine activity	4/781	235/18367	0.991025392397604	0.999707217598881	GDF15/GREM2/MIF/CMTM8	4
GO:0030594	neurotransmitter receptor activity	1/781	111/18367	0.992077462620165	0.999707217598881	GABRE	1
GO:0015267	channel activity	11/781	480/18367	0.992941664557521	0.999707217598881	FXYD3/CLIC3/KCNN4/BCL2/ANXA6/GABRE/TMEM150C/CLCN3/TMEM37/KCNG1/CLDN4	11
GO:0022803	passive transmembrane transporter activity	11/781	481/18367	0.993112909418204	0.999707217598881	FXYD3/CLIC3/KCNN4/BCL2/ANXA6/GABRE/TMEM150C/CLCN3/TMEM37/KCNG1/CLDN4	11
GO:0008168	methyltransferase activity	3/781	214/18367	0.995097680323437	0.999707217598881	KMT2C/PCMTD1/RNMT	3
GO:0016741	transferase activity, transferring one-carbon groups	3/781	225/18367	0.996688594018855	0.999707217598881	KMT2C/PCMTD1/RNMT	3
GO:0022843	voltage-gated cation channel activity	1/781	143/18367	0.998046982356511	0.999707217598881	KCNG1	1
GO:0008528	G protein-coupled peptide receptor activity	1/781	147/18367	0.998360884111758	0.999707217598881	LGR4	1
GO:0001653	peptide receptor activity	1/781	153/18367	0.998739819153351	0.999707217598881	LGR4	1
GO:0003823	antigen binding	1/781	171/18367	0.999427636812823	0.999707217598881	SLC7A5	1
GO:0005261	cation channel activity	4/781	335/18367	0.999707217598881	0.999707217598881	KCNN4/ANXA6/TMEM37/KCNG1	4