ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0016050 vesicle organization 44/770 300/18722 2.01216024409678e-13 1.00265944963343e-09 SQSTM1/ANXA1/RAB11A/VAV3/SDC1/BCL2/ARL8B/DYSF/HOOK3/WASL/EEA1/CLCN3/SYT7/ABCG1/TBC1D20/CLN3/RAB1A/SAR1A/CHMP2B/UVRAG/ARF1/TMED9/VPS4B/PI4K2A/SAR1B/ZFYVE16/SYNJ1/TSG101/STX5/HOOK2/VPS37A/RAB7A/OSBP/SNAP23/CHMP4B/INSIG1/PAFAH1B1/GOSR1/PDCD6/USP8/TFG/SEC31A/CHMP2A/AP2M1 44 GO:0048193 Golgi vesicle transport 43/770 296/18722 5.30605273574131e-13 1.32200303910995e-09 GOLGA4/PLPP3/SPIRE2/CREB3L2/KRT18/GOLGA2/VCP/EHD3/AP2A1/ARF4/RER1/TBC1D20/KDELR2/CLN3/RAB1A/SAR1A/NAPA/SCYL1/LMAN2/UVRAG/ARF1/TRIP11/TMED9/SAR1B/GOLGA5/STX5/KDELR1/ERGIC3/SNAP23/GABARAPL2/INSIG1/CUX1/TMED1/EXOC6B/GOSR1/PDCD6/COPB2/TFG/RP2/COPB1/TMED4/COMMD1/SEC31A 43 GO:0016236 macroautophagy 41/770 291/18722 5.10020777442144e-12 8.471445113314e-09 SQSTM1/HSPB8/NUPR1/HMOX1/MAP1LC3B/GABARAPL1/ATG9B/ATP6V1G1/ARL8B/ATP6V1E1/MAP1LC3A/ATG2A/ERN1/VCP/ATP6V1D/ATP6V0A1/ATP6V0D1/SLC25A5/CLN3/RAB1A/ATP6V0B/CHMP2B/VPS26A/UVRAG/FEZ2/LGALS8/VPS4B/TSG101/ATP6V0E1/RAB5A/ATP6V1C1/SNX6/VPS37A/RAB7A/TBK1/UBQLN1/GABARAPL2/CHMP4B/UBA5/RHEB/CHMP2A 41 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 25/770 130/18722 9.89295571796898e-11 1.23241495856599e-07 CREB3L2/GOLGA2/VCP/ARF4/TBC1D20/KDELR2/RAB1A/SAR1A/LMAN2/ARF1/TRIP11/TMED9/SAR1B/STX5/KDELR1/ERGIC3/INSIG1/TMED1/GOSR1/PDCD6/COPB2/TFG/COPB1/TMED4/SEC31A 25 GO:0010498 proteasomal protein catabolic process 53/770 490/18722 1.31166837119365e-10 1.30720869873159e-07 DAB2/NUPR1/SIAH1/PMAIP1/UBE2B/NEDD4L/RYBP/SIAH2/GNA12/DDIT3/UBE2A/UBR1/HERPUD1/HECTD1/VCP/PSMD7/OPHN1/DNAJB9/HSPA5/PSMC4/CEBPA/PSMC1/EDEM1/PSMB1/SKP1/MDM2/ERLEC1/DDB1/CDK2/DDA1/UBE2H/CTNNB1/PSMD6/PSMB4/CSNK1A1/PSMD1/HSPA1B/APPBP2/CALR/PSMD8/CSNK1E/UBQLN1/GABARAPL2/PSMC3/UBXN1/PSMA1/PSMC6/PSMD4/COMMD1/PSMD14/PSMB5/PSMB6/NFE2L2 53 GO:0006986 response to unfolded protein 25/770 137/18722 3.19685682684851e-10 2.65498959469769e-07 HSPB8/HSPB1/ATF3/DDIT3/DNAJB4/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/CREBRF/EDEM1/TMEM33/ERLEC1/HSPA1B/DNAJB1/MANF/HSP90AA1/DNAJA1/HSPA8/NFE2L2/HSPE1/HSPD1 25 GO:0042176 regulation of protein catabolic process 44/770 391/18722 1.48427562185250e-09 1.05659220338443e-06 DAB2/NUPR1/EGFR/MYLIP/NEDD4L/EZR/PTTG1IP/RYBP/GNA12/HERPUD1/HECTD1/VCP/OPHN1/PSMC4/FURIN/CEBPA/PSMC1/SNX9/MDM2/EGLN2/DDB1/CDK2/DDA1/PSMD3/LDLR/CSNK1A1/PSMD1/HSPA1B/LRP1/STX5/RAB7A/CSNK1E/UBQLN1/GABARAPL2/PSMC3/GPC3/AZIN1/HSP90AA1/UBXN1/USP8/PSMC6/COMMD1/PSMD14/NFE2L2 44 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 45/770 412/18722 2.48600400525927e-09 1.54846974477587e-06 DAB2/SIAH1/UBE2B/NEDD4L/RYBP/SIAH2/GNA12/DDIT3/UBE2A/UBR1/HERPUD1/HECTD1/VCP/PSMD7/DNAJB9/HSPA5/PSMC4/CEBPA/PSMC1/EDEM1/SKP1/MDM2/ERLEC1/DDB1/CDK2/DDA1/UBE2H/CTNNB1/PSMD6/CSNK1A1/PSMD1/HSPA1B/APPBP2/CALR/PSMD8/CSNK1E/UBQLN1/PSMC3/UBXN1/PSMC6/PSMD4/COMMD1/PSMD14/PSMB5/NFE2L2 45 GO:0045732 positive regulation of protein catabolic process 31/770 231/18722 6.77114143579939e-09 3.74895530828759e-06 DAB2/NUPR1/MYLIP/NEDD4L/EZR/PTTG1IP/HERPUD1/HECTD1/VCP/PSMC4/FURIN/CEBPA/PSMC1/SNX9/MDM2/EGLN2/DDB1/DDA1/LDLR/CSNK1A1/HSPA1B/LRP1/STX5/RAB7A/CSNK1E/UBQLN1/PSMC3/GPC3/HSP90AA1/PSMC6/NFE2L2 31 GO:0035966 response to topologically incorrect protein 25/770 159/18722 7.89978678656708e-09 3.93646375574638e-06 HSPB8/HSPB1/ATF3/DDIT3/DNAJB4/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/CREBRF/EDEM1/TMEM33/ERLEC1/HSPA1B/DNAJB1/MANF/HSP90AA1/DNAJA1/HSPA8/NFE2L2/HSPE1/HSPD1 25 GO:1903362 regulation of cellular protein catabolic process 32/770 255/18722 2.01022665636083e-08 9.10632675331454e-06 DAB2/NUPR1/MYLIP/EZR/PTTG1IP/RYBP/GNA12/HERPUD1/HECTD1/VCP/OPHN1/PSMC4/FURIN/CEBPA/PSMC1/MDM2/CDK2/DDA1/LDLR/CSNK1A1/HSPA1B/LRP1/CSNK1E/UBQLN1/GABARAPL2/PSMC3/HSP90AA1/UBXN1/PSMC6/COMMD1/PSMD14/NFE2L2 32 GO:0016241 regulation of macroautophagy 22/770 141/18722 7.15027039594047e-08 2.96914978191428e-05 HSPB8/NUPR1/HMOX1/ATP6V1G1/ATP6V1E1/ERN1/ATP6V1D/ATP6V0A1/ATP6V0D1/SLC25A5/CLN3/ATP6V0B/VPS26A/UVRAG/FEZ2/ATP6V0E1/ATP6V1C1/SNX6/TBK1/UBQLN1/CHMP4B/RHEB 22 GO:0019058 viral life cycle 35/770 317/18722 1.14841191328286e-07 4.40195120299114e-05 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/BCL2/ARL8B/KPNA6/VCP/EEA1/FURIN/P4HB/TBC1D20/RAB1A/CD46/CHMP2B/UVRAG/DDB1/DDX3X/BSG/VPS4B/LDLR/PPIB/HSPA1B/TSG101/RAB5A/VPS37A/RAB7A/NRP1/CHMP4B/STOM/STAU1/HSPA8/CHMP2A 35 GO:0006900 vesicle budding from membrane 14/770 61/18722 1.31409574514648e-07 4.67724221290349e-05 WASL/TBC1D20/RAB1A/SAR1A/ARF1/TMED9/SAR1B/RAB7A/CHMP4B/INSIG1/PDCD6/TFG/SEC31A/AP2M1 14 GO:0007032 endosome organization 16/770 82/18722 1.89012666434055e-07 5.64836925151109e-05 SQSTM1/RAB11A/HOOK3/EEA1/CLCN3/CHMP2B/VPS4B/PI4K2A/SYNJ1/TSG101/HOOK2/VPS37A/RAB7A/CHMP4B/USP8/CHMP2A 16 GO:0051650 establishment of vesicle localization 23/770 161/18722 1.9056771843113e-07 5.64836925151109e-05 PRKCZ/RAB11A/WASL/LIMK2/CLN3/RAB1A/SAR1A/ARF1/TRIP11/CTNNB1/TMED9/SAR1B/SYNJ1/TBC1D23/MYO6/CCDC186/SNAP23/EXOC6B/PAFAH1B1/GOSR1/PDCD6/TFG/ACTN4 23 GO:0009896 positive regulation of catabolic process 46/770 492/18722 1.92699733645773e-07 5.64836925151109e-05 HSPB8/DAB2/NUPR1/HMOX1/PIK3C2A/MYLIP/NEDD4L/EZR/PTTG1IP/APP/ABHD5/SH3BP4/HERPUD1/HECTD1/VCP/DHX36/PSMC4/SLC25A5/FURIN/CEBPA/PSMC1/SNX9/MDM2/UVRAG/EGLN2/DDB1/DDA1/IRS2/GIGYF2/LDLR/CSNK1A1/HSPA1B/LRP1/STX5/PNPLA2/RAB7A/TBK1/CSNK1E/UBQLN1/AGO2/PSMC3/GPC3/HSP90AA1/TMEM59/PSMC6/NFE2L2 46 GO:0061136 regulation of proteasomal protein catabolic process 25/770 187/18722 2.09462277846706e-07 5.79861405838964e-05 DAB2/NUPR1/RYBP/GNA12/HERPUD1/HECTD1/VCP/OPHN1/PSMC4/CEBPA/PSMC1/MDM2/CDK2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/GABARAPL2/PSMC3/UBXN1/PSMC6/COMMD1/PSMD14/NFE2L2 25 GO:1903364 positive regulation of cellular protein catabolic process 22/770 155/18722 3.92803575935769e-07 0.00010301790625726 DAB2/NUPR1/EZR/PTTG1IP/HERPUD1/HECTD1/VCP/PSMC4/CEBPA/PSMC1/MDM2/DDA1/LDLR/CSNK1A1/HSPA1B/LRP1/CSNK1E/UBQLN1/PSMC3/HSP90AA1/PSMC6/NFE2L2 22 GO:0007030 Golgi organization 22/770 157/18722 4.92129981330143e-07 0.000122614184848405 GOLGB1/FHDC1/RAB2A/GOLGA2/EHD3/AKAP9/PDE4DIP/TBC1D20/RAB1A/SURF4/PLEKHM2/LMAN2/TRIP11/TMED9/PI4K2A/GOLGA5/CSNK1A1/STX5/GORASP2/CAMSAP2/TMED1/TMED4 22 GO:0051656 establishment of organelle localization 38/770 390/18722 8.21053377539762e-07 0.000194824237156221 PRKCZ/HMOX1/UBE2B/RAB11A/EZR/SPIRE2/HOOK3/WASL/GATA2/LIMK2/CLN3/RAB1A/SAR1A/SYNE2/PDPK1/CHMP2B/ARF1/NUMA1/TRIP11/CTNNB1/TMED9/VPS4B/SAR1B/SYNJ1/TBC1D23/MYO6/CCDC186/SNAP23/ARMCX3/CHMP4B/EXOC6B/PAFAH1B1/GOSR1/PDCD6/EML4/TFG/ACTN4/CHMP2A 38 GO:0048608 reproductive structure development 40/770 424/18722 9.67905948486359e-07 0.000210849432998984 CGA/CYP19A1/TBX3/ANXA1/ARID5B/NUPR1/PHLDA2/CEBPB/GATA3/BASP1/SPINT1/SDC1/HES1/BCL2/EPAS1/LGR4/GLI3/GCM1/MME/HECTD1/GATA2/KRT8/HSPA5/CEBPA/TBC1D20/EIF2S2/PPARD/ADGRG1/SPINT2/KDM5B/CTNNB1/BSG/RDH10/EIF2B2/SERPINF1/DNAJB6/MAP3K4/RHOBTB3/ADM/SOD1 40 GO:0016197 endosomal transport 27/770 230/18722 9.73216327308173e-07 0.000210849432998984 SQSTM1/RAB11A/RAB9A/TINAGL1/SPAG9/ARL8B/SNX27/ERC1/VCP/EHD3/EEA1/LEPROT/GRIP1/SNX9/CHMP2B/VPS26A/TOM1/VPS4B/ZFYVE16/TBC1D23/STX5/SNX6/RAB7A/CHMP4B/GOSR1/RHOBTB3/CHMP2A 27 GO:0051648 vesicle localization 23/770 177/18722 1.05803332688325e-06 0.000219674169494135 PRKCZ/RAB11A/WASL/LIMK2/CLN3/RAB1A/SAR1A/ARF1/TRIP11/CTNNB1/TMED9/SAR1B/SYNJ1/TBC1D23/MYO6/CCDC186/SNAP23/EXOC6B/PAFAH1B1/GOSR1/PDCD6/TFG/ACTN4 23 GO:0061458 reproductive system development 40/770 427/18722 1.15706714183429e-06 0.00023062662271041 CGA/CYP19A1/TBX3/ANXA1/ARID5B/NUPR1/PHLDA2/CEBPB/GATA3/BASP1/SPINT1/SDC1/HES1/BCL2/EPAS1/LGR4/GLI3/GCM1/MME/HECTD1/GATA2/KRT8/HSPA5/CEBPA/TBC1D20/EIF2S2/PPARD/ADGRG1/SPINT2/KDM5B/CTNNB1/BSG/RDH10/EIF2B2/SERPINF1/DNAJB6/MAP3K4/RHOBTB3/ADM/SOD1 40 GO:0016032 viral process 39/770 415/18722 1.45451035494598e-06 0.000278762503795992 ST3GAL4/TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/HEXIM1/BCL2/ARL8B/KPNA6/VCP/EEA1/FURIN/P4HB/TBC1D20/RAB1A/GTF2B/CD46/CHMP2B/UVRAG/DDB1/DDX3X/BSG/VPS4B/LDLR/PPIB/HSPA1B/TSG101/RAB5A/VPS37A/RAB7A/NRP1/PSMC3/CHMP4B/STOM/STAU1/HSPA8/CHMP2A 39 GO:0016482 cytosolic transport 22/770 168/18722 1.58444191582354e-06 0.000292417558020322 DAB2/RAB9A/EZR/SPAG9/ARL8B/ERC1/EHD3/HOOK3/AP2A1/EEA1/SYT7/CLN3/VPS26A/RAB21/TBC1D23/STX5/RAB5A/HOOK2/SNX6/RAB7A/GOSR1/RHOBTB3 22 GO:0034620 cellular response to unfolded protein 16/770 96/18722 1.75282396624948e-06 0.00031194006513647 HSPB8/ATF3/DDIT3/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/TMEM33/ERLEC1/HSPA1B/HSPA8/NFE2L2/HSPD1 16 GO:0007034 vacuolar transport 21/770 157/18722 1.92640733204755e-06 0.000331009921916998 ARL8B/SNX27/VCP/EHD3/HOOK3/LEPROT/ATP6V0D1/CLN3/CHMP2B/ARF1/VPS4B/ZFYVE16/LRP1/TSG101/HOOK2/VPS37A/RAB7A/CHMP4B/TMEM106B/HSPA8/CHMP2A 21 GO:0072659 protein localization to plasma membrane 30/770 284/18722 2.30846636029209e-06 0.000383436262444517 SQSTM1/DAB2/PRKCZ/EGFR/RAB11A/EZR/GOLGA4/EPB41L3/KRT18/HECTD1/EHD3/JUP/RER1/GRIP1/CLN3/TTC7B/PPFIA1/PDPK1/ZDHHC3/CRB3/BSG/LRP1/MAP7/TMBIM1/RAB7A/GORASP2/SORBS1/TMEM59/TMEM150A/AP2M1 30 GO:0034976 response to endoplasmic reticulum stress 28/770 256/18722 2.53555440194969e-06 0.000407569922094042 NUPR1/PMAIP1/CEBPB/NRBF2/ATF3/BCL2/DDIT3/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/P4HB/EDEM1/TMEM33/ERLEC1/DDX3X/PDIA3/CALR/GORASP2/UBQLN1/MANF/UBXN1/UBA5/PSMC6/NFE2L2 28 GO:0031331 positive regulation of cellular catabolic process 39/770 427/18722 2.91759656161502e-06 0.000454324489578989 HSPB8/DAB2/NUPR1/HMOX1/PIK3C2A/EZR/PTTG1IP/APP/ABHD5/SH3BP4/HERPUD1/HECTD1/VCP/DHX36/PSMC4/SLC25A5/FURIN/CEBPA/PSMC1/SNX9/MDM2/UVRAG/DDA1/IRS2/GIGYF2/LDLR/CSNK1A1/HSPA1B/LRP1/PNPLA2/TBK1/CSNK1E/UBQLN1/AGO2/PSMC3/HSP90AA1/TMEM59/PSMC6/NFE2L2 39 GO:0045807 positive regulation of endocytosis 16/770 100/18722 3.05604719406144e-06 0.000461463126303277 DAB2/NEDD4L/SERPINE1/CD63/WASL/AP2A1/GATA2/MIB1/CLN3/RAB21/ARF1/SYNJ1/LRP1/TSG101/GPC3/AP2M1 16 GO:1904375 regulation of protein localization to cell periphery 18/770 125/18722 3.57840460474944e-06 0.000524446768984308 SQSTM1/DAB2/PRKCZ/EGFR/RAB11A/EZR/GNAI1/HECTD1/RER1/CLN3/PPFIA1/PDPK1/NUMA1/LRP1/TMBIM1/SORBS1/TMEM59/AP2M1 18 GO:1901800 positive regulation of proteasomal protein catabolic process 17/770 114/18722 4.08991328274471e-06 0.000582286796797625 DAB2/NUPR1/HERPUD1/HECTD1/VCP/PSMC4/CEBPA/PSMC1/MDM2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/PSMC3/PSMC6/NFE2L2 17 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 25/770 221/18722 4.76023560416518e-06 0.00065889594487653 DAB2/NUPR1/RYBP/GNA12/HERPUD1/HECTD1/VCP/OPHN1/PSMC4/CEBPA/PSMC1/MDM2/CDK2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/GABARAPL2/PSMC3/UBXN1/PSMC6/COMMD1/PSMD14/NFE2L2 25 GO:0007033 vacuole organization 22/770 180/18722 5.01978531655407e-06 0.000676042979253755 NUPR1/MAP1LC3B/GABARAPL1/ATG9B/ARL8B/MAP1LC3A/ATG2A/HOOK3/SYT7/CLN3/RAB1A/CLN8/CHMP2B/ARF1/FEZ2/RAB5A/HOOK2/RAB7A/UBQLN1/GABARAPL2/CHMP4B/TMEM106B 22 GO:0010506 regulation of autophagy 31/770 317/18722 7.7790806718809e-06 0.0010200831312627 HSPB8/HSPB1/NUPR1/HMOX1/PIK3C2A/EIF4G2/BCL2/DDIT3/ATP6V1G1/ATP6V1E1/SH3BP4/RRAGC/ERN1/GOLGA2/ATP6V1D/ATP6V0A1/ATP6V0D1/SLC25A5/CLN3/ATP6V0B/VPS26A/UVRAG/FEZ2/ATP6V0E1/ATP6V1C1/SNX6/TBK1/UBQLN1/CHMP4B/TMEM59/RHEB 31 GO:1990778 protein localization to cell periphery 32/770 333/18722 8.00666984840805e-06 0.00102300604755429 SQSTM1/DAB2/PRKCZ/EGFR/RAB11A/EZR/GOLGA4/EPB41L3/GNAI1/KRT18/HECTD1/EHD3/JUP/RER1/GRIP1/CLN3/TTC7B/PPFIA1/PDPK1/ZDHHC3/NUMA1/CRB3/BSG/LRP1/MAP7/TMBIM1/RAB7A/GORASP2/SORBS1/TMEM59/TMEM150A/AP2M1 32 GO:0007173 epidermal growth factor receptor signaling pathway 16/770 108/18722 8.50911781468518e-06 0.00106002335176441 PIK3C2A/EGFR/BRAF/IFI6/ARF4/GRB7/MVP/PDPK1/DUSP3/RPS6KA5/TSG101/SNX6/RAB7A/GAREM1/ERRFI1/EFEMP1 16 GO:0032535 regulation of cellular component size 35/770 382/18722 8.73413811468816e-06 0.00106151732257295 SEMA6A/EIF4G2/RAB11A/RASA1/SCIN/VAV3/EZR/GOLGA4/KCNN4/SEMA7A/SPIRE2/FMN1/WASL/CLCN3/DIP2B/CLN3/JMY/CDC42EP4/SNX9/CLN8/RAB21/ARF1/SLC12A4/RICTOR/AKT1S1/LRP1/RAB5A/KANK1/MAP3K13/NRP1/PAFAH1B1/ARHGAP18/CDKL5/AP2M1/IQGAP2 35 GO:0001701 in utero embryonic development 34/770 367/18722 9.25550351092814e-06 0.00109809938083226 TBX3/MAFF/UBE2B/PHLDA2/CEBPB/GATA3/HOPX/SPINT1/HES1/EPAS1/UBE2A/GLI3/GCM1/MBD3/SBDS/ELF3/MAFG/HECTD1/GATA2/KRT8/MIB1/PSMC4/FURIN/CEBPA/EIF2S2/SPINT2/CTNNB1/SUPT6H/RDH10/DNAJB6/RBBP6/CMIP/ZFAND5/ADM 34 GO:0044403 biological process involved in symbiotic interaction 29/770 290/18722 9.90711244065298e-06 0.00114807305329707 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/ARL8B/SERPINB9/P4HB/TBC1D20/CD46/CHMP2B/UVRAG/DDB1/BSG/VPS4B/LDLR/PPIB/HSPA1B/TSG101/RAB7A/NRP1/PSMC3/CHMP4B/STOM/ALYREF/HSPA8/CHMP2A/HSPD1 29 GO:0009408 response to heat 16/770 110/18722 1.08111393447363e-05 0.00119401148306252 HMOX1/DNAJB4/VCP/DHX36/SLC52A3/DNAJA2/RBBP7/HSPA1B/EIF2B2/DNAJB1/DNAJB6/HSP90AA1/PDCD6/DNAJA1/SOD1/HSPD1 16 GO:0052126 movement in host environment 21/770 175/18722 1.09059150797636e-05 0.00119401148306252 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/ARL8B/P4HB/CD46/CHMP2B/UVRAG/DDB1/BSG/VPS4B/LDLR/HSPA1B/TSG101/RAB7A/NRP1/CHMP4B/CHMP2A 21 GO:0051701 biological process involved in interaction with host 23/770 203/18722 1.10223817420984e-05 0.00119401148306252 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/ARL8B/SERPINB9/P4HB/CD46/CHMP2B/UVRAG/DDB1/BSG/VPS4B/LDLR/HSPA1B/TSG101/RAB7A/NRP1/CHMP4B/ALYREF/CHMP2A 23 GO:0006903 vesicle targeting 10/770 45/18722 1.12661236035217e-05 0.00119444880673082 SAR1A/TRIP11/TMED9/SAR1B/TBC1D23/SNAP23/EXOC6B/GOSR1/PDCD6/TFG 10 GO:0045862 positive regulation of proteolysis 34/770 372/18722 1.23306141010242e-05 0.00128007187636258 DAB2/NUPR1/PMAIP1/FBLN1/APP/HERPUD1/HECTD1/VCP/PSMC4/PCOLCE2/FURIN/CEBPA/PSMC1/SNX9/MDM2/ADRM1/DDA1/DDX3X/PRELID1/AKIRIN2/TANK/CSNK1A1/HSPA1B/CLPX/CSNK1E/UBQLN1/PSMC3/PDCD6/PSMC6/PSMD14/CLDN4/NFE2L2/HSPE1/HSPD1 34 GO:0009266 response to temperature stimulus 21/770 178/18722 1.41872160724089e-05 0.00144275301405742 HMOX1/DNAJB4/NFKBIA/VCP/DHX36/SLC52A3/NR2F6/ACADVL/DNAJA2/RBBP7/HSPA1B/SLC9A1/EIF2B2/DNAJB1/DNAJB6/HSP90AA1/PDCD6/DNAJA1/ADM/SOD1/HSPD1 21 GO:0090114 COPII-coated vesicle budding 8/770 29/18722 1.56992607983349e-05 0.00156458833116206 TBC1D20/RAB1A/SAR1A/SAR1B/INSIG1/PDCD6/TFG/SEC31A 8 GO:0061077 chaperone-mediated protein folding 12/770 67/18722 1.60851332416714e-05 0.00157161213614213 HSPB1/DNAJB4/HSPA5/FKBP2/BAG1/PPIB/HSPA1B/DNAJB1/DNAJB6/HSPA8/ST13/HSPE1 12 GO:0070997 neuron death 33/770 361/18722 1.64457603808547e-05 0.00157594661495767 NUPR1/HMOX1/SIAH1/KMO/CEBPB/GATA3/RASA1/TFAP2A/APP/BCL2/DDIT3/CPEB4/CD200/GHR/HSPA5/PSMC1/ERBB3/CLN3/TNFRSF21/PDPK1/EGLN2/UBE2M/CTNNB1/AKT1S1/LRP1/SNX6/SLC9A1/TBK1/NRP1/CHMP4B/SERPINF1/SOD1/HSPD1 33 GO:0007041 lysosomal transport 16/770 114/18722 1.71392628091443e-05 0.00161141408637672 ARL8B/SNX27/VCP/EHD3/HOOK3/CLN3/CHMP2B/ARF1/VPS4B/ZFYVE16/LRP1/TSG101/HOOK2/RAB7A/TMEM106B/HSPA8 16 GO:0043434 response to peptide hormone 36/770 414/18722 2.04840999795876e-05 0.00187558727213278 GDF15/ANXA1/PRKCZ/CYP11A1/SLC2A1/HSD11B2/PIK3C2A/GNAI1/HDAC5/GHR/SOCS1/GGH/JUND/BTG1/RAP1B/LEPROT/FOXO4/PDPK1/MDM2/SRSF5/SYAP1/IRS2/BSG/CDO1/KANK1/SLC9A1/EIF2B2/STXBP3/INSIG1/SORBS1/SLC2A8/ERRFI1/TGFBR3/ADM/NFE2L2/CCND3 36 GO:0030100 regulation of endocytosis 23/770 211/18722 2.07018462707812e-05 0.00187558727213278 DAB2/NEDD4L/SERPINE1/CD63/AAK1/LRPAP1/WASL/AP2A1/GATA2/OPHN1/MIB1/CLN3/RAB21/RAB5B/ARF1/ZFYVE16/RAB4B/SYNJ1/LRP1/TSG101/RAB5A/GPC3/AP2M1 23 GO:0035967 cellular response to topologically incorrect protein 16/770 116/18722 2.13955527179802e-05 0.00190382212845884 HSPB8/ATF3/DDIT3/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/TMEM33/ERLEC1/HSPA1B/HSPA8/NFE2L2/HSPD1 16 GO:0006457 protein folding 23/770 212/18722 2.23397010089295e-05 0.00191893786646924 HSPB1/DNAJB4/HSPA5/P4HB/FKBP2/BAG1/DNAJA2/SIL1/PPIB/PDIA3/HSPA1B/CALR/CLPX/DNAJB1/DNAJB6/HSP90AA1/DNAJA1/RP2/TBCA/HSPA8/ST13/HSPE1/HSPD1 23 GO:1903076 regulation of protein localization to plasma membrane 15/770 104/18722 2.2442899189494e-05 0.00191893786646924 SQSTM1/DAB2/EGFR/RAB11A/EZR/HECTD1/RER1/CLN3/PPFIA1/PDPK1/LRP1/TMBIM1/SORBS1/TMEM59/AP2M1 15 GO:0060070 canonical Wnt signaling pathway 29/770 303/18722 2.27207172630314e-05 0.00191893786646924 DAB2/UBE2B/EGFR/GATA3/ZNF703/SIAH2/SDC1/DDIT3/LGR4/GLI3/PLPP3/VCP/BCL9L/JUP/UBR5/DVL3/LATS2/TNKS2/DDX3X/CTNNB1/DLX5/GSKIP/CSNK1A1/RAB5A/KANK1/CSNK1E/GPC3/USP8/USP47 29 GO:0001890 placenta development 18/770 144/18722 2.62836737888935e-05 0.00217694609227167 PHLDA2/CEBPB/SPINT1/HES1/EPAS1/GCM1/MME/HECTD1/GATA2/KRT8/CEBPA/PPARD/SPINT2/BSG/DNAJB6/MAP3K4/ADM/SOD1 18 GO:0042026 protein refolding 7/770 23/18722 2.66493501161091e-05 0.00217694609227167 HSPA5/DNAJA2/HSPA1B/HSP90AA1/HSPA8/ST13/HSPD1 7 GO:0001892 embryonic placenta development 13/770 82/18722 2.81937459115105e-05 0.00223543914062984 PHLDA2/CEBPB/SPINT1/HES1/EPAS1/GCM1/HECTD1/GATA2/KRT8/CEBPA/SPINT2/DNAJB6/ADM 13 GO:0090263 positive regulation of canonical Wnt signaling pathway 15/770 106/18722 2.82626261006783e-05 0.00223543914062984 UBE2B/EGFR/LGR4/VCP/JUP/UBR5/TNKS2/DDX3X/DLX5/GSKIP/KANK1/CSNK1E/GPC3/USP8/USP47 15 GO:0051402 neuron apoptotic process 25/770 246/18722 3.0508009435155e-05 0.00235180923466503 NUPR1/HMOX1/SIAH1/CEBPB/GATA3/RASA1/TFAP2A/APP/BCL2/DDIT3/CPEB4/HSPA5/ERBB3/CLN3/TNFRSF21/PDPK1/EGLN2/UBE2M/CTNNB1/AKT1S1/LRP1/SNX6/NRP1/SOD1/HSPD1 25 GO:2001233 regulation of apoptotic signaling pathway 32/770 356/18722 3.06778246544705e-05 0.00235180923466503 HSPB1/NUPR1/HMOX1/SIAH1/PMAIP1/PTTG1IP/ATF3/SERPINE1/SIAH2/BCL2/DDIT3/IFI6/HERPUD1/SLC25A5/DEDD2/P4HB/MDM2/LMNA/DDX3X/CTNNB1/PRELID1/PDIA3/HSPA1B/TMBIM1/UBQLN1/NRP1/MIF/DNAJA1/GHITM/USP47/SOD1/NFE2L2 32 GO:0022604 regulation of cell morphogenesis 29/770 309/18722 3.26647345060578e-05 0.00243403682447773 ANXA1/RHOBTB1/RASA1/NEDD4L/EZR/FBLN1/SPAG9/EPB41L3/FGD6/MYO10/BCL9L/DHX36/GRIP1/DVL3/P4HB/CDC42EP4/RAB21/CALR/KANK1/MAP3K13/NRP1/CUX1/PAFAH1B1/ARHGAP18/CDKL5/RHOBTB3/ACTN4/CLDN4/FERMT2 29 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 17/770 133/18722 3.27273664940815e-05 0.00243403682447773 DAB2/NUPR1/HERPUD1/HECTD1/VCP/PSMC4/CEBPA/PSMC1/MDM2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/PSMC3/PSMC6/NFE2L2 17 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 17/770 134/18722 3.60750875308391e-05 0.00262809201484119 DAB2/RYBP/GNA12/HERPUD1/HECTD1/VCP/CEBPA/MDM2/CDK2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/UBXN1/COMMD1/NFE2L2 17 GO:0038127 ERBB signaling pathway 16/770 121/18722 3.63914005667354e-05 0.00262809201484119 PIK3C2A/EGFR/BRAF/IFI6/ARF4/GRB7/MVP/PDPK1/DUSP3/RPS6KA5/TSG101/SNX6/RAB7A/GAREM1/ERRFI1/EFEMP1 16 GO:0052547 regulation of peptidase activity 38/770 461/18722 3.96274056844679e-05 0.00282090517893863 PMAIP1/SERPINB2/FBLN1/SPINT1/APP/SERPINE1/SIAH2/CRIM1/IFI6/HERPUD1/VCP/PCOLCE2/FURIN/ITIH5/SERPINB9/MDM2/SPINT2/ADRM1/DDX3X/FNIP1/APLP2/PRELID1/AKIRIN2/TANK/LRP1/CLPX/GPC3/SERPINF1/DNAJB6/PDCD6/UBXN1/PSMD14/USP47/CLDN4/TNFAIP8/HSPE1/HSPD1/CAST 38 GO:0045773 positive regulation of axon extension 9/770 42/18722 4.22358418726513e-05 0.00296424225424537 EIF4G2/RAB11A/GOLGA4/SEMA7A/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 9 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 10/770 52/18722 4.30673204303582e-05 0.0029806174681177 PLPP3/ARF4/RER1/KDELR2/SCYL1/LMAN2/UVRAG/KDELR1/ERGIC3/COPB2 10 GO:0048638 regulation of developmental growth 30/770 330/18722 4.36828283521061e-05 0.00298180183121294 CGA/GDF15/SEMA6A/EIF4G2/BASP1/RAB11A/NEDD4L/EZR/GOLGA4/HOPX/APP/SPAG9/BCL2/DUSP9/SEMA7A/GHR/SERP1/DIP2B/LATS2/PPARD/TNKS2/RAB21/PPIB/LRP1/MAP3K13/NRP1/PAFAH1B1/TGFBR3/CDKL5/SOD1 30 GO:0030968 endoplasmic reticulum unfolded protein response 12/770 74/18722 4.52314625376676e-05 0.00304578888952969 ATF3/DDIT3/ERN1/CREB3L2/HERPUD1/VCP/SERP1/DNAJB9/HSPA5/TMEM33/ERLEC1/NFE2L2 12 GO:0007565 female pregnancy 21/770 193/18722 4.80243415157684e-05 0.00318819390737278 PGF/SLC2A1/HSD11B2/SLC38A1/FBLN1/AKR1B1/BCL2/UBE2A/SLC19A1/KPNA6/TEAD3/STS/PPARD/ITGB4/BSG/CALR/PRLR/AGO2/ADM/CLDN4/SOD1 21 GO:0090169 regulation of spindle assembly 7/770 25/18722 4.86258753683186e-05 0.00318819390737278 CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CHMP4B/CHMP2A 7 GO:0006458 'de novo' protein folding 9/770 43/18722 5.14850087404452e-05 0.00333181556563167 DNAJB4/HSPA5/BAG1/HSPA1B/DNAJB1/HSPA8/ST13/HSPE1/HSPD1 9 GO:0019076 viral release from host cell 8/770 34/18722 5.53390673480845e-05 0.00340437743945068 ARL8B/CHMP2B/DDB1/VPS4B/TSG101/RAB7A/CHMP4B/CHMP2A 8 GO:0035890 exit from host 8/770 34/18722 5.53390673480845e-05 0.00340437743945068 ARL8B/CHMP2B/DDB1/VPS4B/TSG101/RAB7A/CHMP4B/CHMP2A 8 GO:0035891 exit from host cell 8/770 34/18722 5.53390673480845e-05 0.00340437743945068 ARL8B/CHMP2B/DDB1/VPS4B/TSG101/RAB7A/CHMP4B/CHMP2A 8 GO:0051085 chaperone cofactor-dependent protein refolding 8/770 34/18722 5.53390673480845e-05 0.00340437743945068 DNAJB4/HSPA5/BAG1/HSPA1B/DNAJB1/HSPA8/ST13/HSPE1 8 GO:0050769 positive regulation of neurogenesis 23/770 225/18722 5.71984421166106e-05 0.00345878890886773 EGFR/EIF4G2/RAB11A/GOLGA4/SPINT1/HES1/TGM2/GLI3/MME/SEMA7A/DHX36/ID2/RAB21/CTNNB1/SYNJ1/LRP1/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/RHEB 23 GO:1901673 regulation of mitotic spindle assembly 6/770 18/18722 5.76117759253504e-05 0.00345878890886773 CCSAP/CHMP2B/VPS4B/HSPA1B/CHMP4B/CHMP2A 6 GO:0048524 positive regulation of viral process 11/770 65/18722 6.23409489454592e-05 0.00369815414994313 KPNA6/P4HB/TBC1D20/CHMP2B/DDB1/DDX3X/TSG101/RAB7A/STOM/STAU1/CHMP2A 11 GO:0033522 histone H2A ubiquitination 7/770 26/18722 6.41914681833935e-05 0.00376313042303353 UBE2B/OTUB2/RYBP/UBE2A/UBR5/SKP1/DDB1 7 GO:0019068 virion assembly 8/770 35/18722 6.91704757507141e-05 0.00396179862834262 TBC1D20/RAB1A/CHMP2B/VPS4B/TSG101/VPS37A/CHMP4B/CHMP2A 8 GO:0060236 regulation of mitotic spindle organization 8/770 35/18722 6.91704757507141e-05 0.00396179862834262 GNAI1/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CHMP4B/CHMP2A 8 GO:1905037 autophagosome organization 14/770 103/18722 8.13066063458867e-05 0.00460398658433583 NUPR1/MAP1LC3B/GABARAPL1/ATG9B/MAP1LC3A/ATG2A/CLN3/RAB1A/FEZ2/RAB5A/RAB7A/UBQLN1/GABARAPL2/CHMP4B 14 GO:0031122 cytoplasmic microtubule organization 10/770 56/18722 8.35648928606971e-05 0.00467869506881858 CLIP1/RAB11A/EZR/HOOK3/LIMK2/NUMA1/HOOK2/SLK/CAMSAP2/PAFAH1B1 10 GO:0048639 positive regulation of developmental growth 19/770 174/18722 0.000103382178883852 0.00572392663753594 EIF4G2/BASP1/RAB11A/NEDD4L/EZR/GOLGA4/HOPX/BCL2/SEMA7A/GHR/SERP1/PPARD/PPIB/LRP1/MAP3K13/NRP1/PAFAH1B1/TGFBR3/CDKL5 19 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 7/770 28/18722 0.000107537439098886 0.00578636330382746 EGFR/MVP/DUSP3/TSG101/SNX6/RAB7A/ERRFI1 7 GO:0034605 cellular response to heat 11/770 69/18722 0.000109409203992437 0.00578636330382746 HMOX1/VCP/DHX36/SLC52A3/RBBP7/HSPA1B/DNAJB1/DNAJB6/HSP90AA1/PDCD6/HSPD1 11 GO:1904377 positive regulation of protein localization to cell periphery 11/770 69/18722 0.000109409203992437 0.00578636330382746 SQSTM1/EGFR/RAB11A/EZR/GNAI1/RER1/CLN3/PDPK1/NUMA1/LRP1/SORBS1 11 GO:0010720 positive regulation of cell development 27/770 298/18722 0.000109677744542387 0.00578636330382746 EGFR/EIF4G2/RAB11A/GOLGA4/SPINT1/HES1/BCL2/TGM2/GLI3/MME/SEMA7A/DHX36/ID2/P4HB/RAB21/CTNNB1/SYNJ1/LRP1/CALR/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/RHEB/FERMT2 27 GO:1905475 regulation of protein localization to membrane 19/770 175/18722 0.000111608046894509 0.00578636330382746 SQSTM1/DAB2/PRKCZ/TCAF1/EGFR/RAB11A/EZR/HECTD1/RER1/CLN3/PPFIA1/PDPK1/LRP1/TMBIM1/GPC3/SORBS1/STOM/TMEM59/AP2M1 19 GO:1990182 exosomal secretion 6/770 20/18722 0.000112093126411466 0.00578636330382746 RAB11A/SDC1/VPS4B/TSG101/RAB7A/CHMP2A 6 GO:0001778 plasma membrane repair 5/770 13/18722 0.000113467603216967 0.00578636330382746 ANXA6/ARL8B/DYSF/SYT7/MYOF 5 GO:0044706 multi-multicellular organism process 22/770 220/18722 0.000113799639529418 0.00578636330382746 PGF/MAFF/SLC2A1/HSD11B2/SLC38A1/FBLN1/AKR1B1/BCL2/UBE2A/SLC19A1/KPNA6/TEAD3/STS/PPARD/ITGB4/BSG/CALR/PRLR/AGO2/ADM/CLDN4/SOD1 22 GO:0007052 mitotic spindle organization 15/770 120/18722 0.000121093182946532 0.00609502354164212 TACC2/RAB11A/GNAI1/SBDS/GOLGA2/VCP/CCSAP/DCTN6/CHMP2B/NUMA1/VPS4B/HSPA1B/TACC1/CHMP4B/CHMP2A 15 GO:0031334 positive regulation of protein-containing complex assembly 23/770 237/18722 0.000126340303558992 0.0062393572469632 TFRC/CLIP1/SCIN/SPIRE2/VCP/AKAP9/FMN1/RAP1B/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/DDX3X/FNIP1/RICTOR/HSPA1B/HSP90AA1/MPP7/PSMC6/FERMT2/IQGAP2 23 GO:1905897 regulation of response to endoplasmic reticulum stress 12/770 82/18722 0.000126464997379748 0.0062393572469632 NUPR1/PMAIP1/DDIT3/ERN1/HERPUD1/DNAJB9/HSPA5/TMEM33/UBQLN1/MANF/UBXN1/NFE2L2 12 GO:0045861 negative regulation of proteolysis 30/770 351/18722 0.000133608932828946 0.00652718933614353 SERPINB2/SPINT1/APP/SERPINE1/RYBP/SIAH2/CRIM1/IFI6/HERPUD1/OPHN1/FURIN/ITIH5/SERPINB9/CLN3/CLN8/MDM2/SPINT2/DDX3X/FNIP1/APLP2/LRP1/GABARAPL2/GPC3/SERPINF1/DNAJB6/UBXN1/TMEM59/USP47/TNFAIP8/CAST 30 GO:1901214 regulation of neuron death 28/770 319/18722 0.00014169461052089 0.00685499266238441 NUPR1/HMOX1/KMO/CEBPB/GATA3/RASA1/TFAP2A/BCL2/DDIT3/CPEB4/CD200/GHR/PSMC1/ERBB3/CLN3/PDPK1/EGLN2/UBE2M/CTNNB1/AKT1S1/LRP1/SNX6/TBK1/NRP1/CHMP4B/SERPINF1/SOD1/HSPD1 28 GO:2001234 negative regulation of apoptotic signaling pathway 22/770 224/18722 0.000147923357662749 0.00705521483001842 HSPB1/HMOX1/PTTG1IP/SERPINE1/SIAH2/BCL2/IFI6/HERPUD1/SLC25A5/MDM2/LMNA/DDX3X/CTNNB1/PRELID1/HSPA1B/TMBIM1/NRP1/MIF/DNAJA1/GHITM/USP47/NFE2L2 22 GO:0039702 viral budding via host ESCRT complex 6/770 21/18722 0.000151496686095118 0.00705521483001842 CHMP2B/VPS4B/TSG101/VPS37A/CHMP4B/CHMP2A 6 GO:0048199 vesicle targeting, to, from or within Golgi 6/770 21/18722 0.000151496686095118 0.00705521483001842 SAR1A/TMED9/SAR1B/GOSR1/PDCD6/TFG 6 GO:0097734 extracellular exosome biogenesis 6/770 21/18722 0.000151496686095118 0.00705521483001842 RAB11A/SDC1/VPS4B/TSG101/RAB7A/CHMP2A 6 GO:0042060 wound healing 34/770 422/18722 0.000154483085372978 0.00708196392447241 ANXA1/HSPB1/ST3GAL4/HMOX1/SERPINB2/EGFR/VAV3/FBLN1/SERPINE1/SDC1/DSP/GNA12/AK3/ANXA6/ARL8B/GLI3/PLPP3/GNAS/DYSF/GATA2/ARHGAP24/F5/SYT7/PHLDB2/ERBB3/PPARD/C1QTNF1/CD59/KANK1/STXBP3/CLDN4/NFE2L2/MYOF/FERMT2 34 GO:0051084 'de novo' posttranslational protein folding 8/770 39/18722 0.00015633474446959 0.00708196392447241 DNAJB4/HSPA5/BAG1/HSPA1B/DNAJB1/HSPA8/ST13/HSPE1 8 GO:0090224 regulation of spindle organization 8/770 39/18722 0.00015633474446959 0.00708196392447241 GNAI1/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CHMP4B/CHMP2A 8 GO:0035437 maintenance of protein localization in endoplasmic reticulum 5/770 14/18722 0.000170540909316901 0.00753496871459349 HSPA5/RER1/KDELR2/KDELR1/INSIG1 5 GO:1901857 positive regulation of cellular respiration 5/770 14/18722 0.000170540909316901 0.00753496871459349 NUPR1/VCP/OPN3/IL10RB/PRELID1 5 GO:0036258 multivesicular body assembly 7/770 30/18722 0.000172098964082567 0.00753496871459349 RAB11A/CHMP2B/VPS4B/TSG101/VPS37A/CHMP4B/CHMP2A 7 GO:1903320 regulation of protein modification by small protein conjugation or removal 23/770 242/18722 0.000172383390219478 0.00753496871459349 SQSTM1/ARRDC3/OTUB2/PTTG1IP/SIAH2/EPAS1/HERPUD1/VCP/HSPA5/UBR5/SKP1/DDX3X/CTNNB1/TANK/HSPA1B/UBQLN1/HSP90AA1/PDCD6/UBXN1/DNAJA1/COMMD1/HMG20B/UBE2I 23 GO:0008361 regulation of cell size 19/770 181/18722 0.000174203847808725 0.00754832846635543 SEMA6A/EIF4G2/RAB11A/VAV3/GOLGA4/KCNN4/SEMA7A/CLCN3/DIP2B/CLN3/CLN8/RAB21/SLC12A4/AKT1S1/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 19 GO:0001656 metanephros development 12/770 85/18722 0.000179471723270648 0.00770954825049687 GATA3/BASP1/AKR1B1/HES1/BCL2/LGR4/GLI3/FMN1/DLG5/CTNNB1/RDH10/GPC3 12 GO:0043523 regulation of neuron apoptotic process 21/770 212/18722 0.000184279820729148 0.00784843031361833 NUPR1/HMOX1/CEBPB/GATA3/RASA1/TFAP2A/BCL2/DDIT3/CPEB4/ERBB3/CLN3/PDPK1/EGLN2/UBE2M/CTNNB1/AKT1S1/LRP1/SNX6/NRP1/SOD1/HSPD1 21 GO:0045022 early endosome to late endosome transport 8/770 40/18722 0.000188448118246109 0.00795794045102003 DAB2/EZR/HOOK3/EEA1/RAB21/RAB5A/HOOK2/RAB7A 8 GO:0006898 receptor-mediated endocytosis 23/770 244/18722 0.000194609239680083 0.00814905749013323 DAB2/TFRC/CTSL/EZR/SERPINE1/CD63/AAK1/CLTA/LRPAP1/WASL/AP2A1/OPHN1/CLN3/SNX9/RAB21/ARF1/LDLR/SYNJ1/LRP1/RAB5A/CLTB/ADM/AP2M1 23 GO:0001822 kidney development 26/770 293/18722 0.000203617820163183 0.00845522998227615 ARID5B/GATA3/BASP1/ARG2/TFAP2A/OVOL1/C1GALT1/AKR1B1/SDC1/HES1/BCL2/LGR4/DACT2/GLI3/MME/MTSS1/FMN1/DLG5/CTNNB1/RDH10/ENPEP/NRP1/GPC3/SERPINF1/PBX1/ADAMTS6 26 GO:0000045 autophagosome assembly 13/770 99/18722 0.000205909696982329 0.00847973570299954 NUPR1/MAP1LC3B/GABARAPL1/ATG9B/MAP1LC3A/ATG2A/RAB1A/FEZ2/RAB5A/RAB7A/UBQLN1/GABARAPL2/CHMP4B 13 GO:0030177 positive regulation of Wnt signaling pathway 16/770 140/18722 0.000210668146172689 0.00860458501949599 DAB2/UBE2B/EGFR/LGR4/VCP/JUP/UBR5/TNKS2/DDX3X/DLX5/GSKIP/KANK1/CSNK1E/GPC3/USP8/USP47 16 GO:0036257 multivesicular body organization 7/770 31/18722 0.00021447110159235 0.00866996251509702 RAB11A/CHMP2B/VPS4B/TSG101/VPS37A/CHMP4B/CHMP2A 7 GO:0007051 spindle organization 19/770 184/18722 0.000215748615667676 0.00866996251509702 TACC2/RAB11A/EZR/GNAI1/SBDS/NEK7/GOLGA2/VCP/CCSAP/LIMK2/DCTN6/CHMP2B/UVRAG/NUMA1/VPS4B/HSPA1B/TACC1/CHMP4B/CHMP2A 19 GO:0010466 negative regulation of peptidase activity 24/770 262/18722 0.000219950134286936 0.00876809215321441 SERPINB2/SPINT1/APP/SERPINE1/SIAH2/CRIM1/IFI6/HERPUD1/FURIN/ITIH5/SERPINB9/MDM2/SPINT2/DDX3X/FNIP1/APLP2/LRP1/GPC3/SERPINF1/DNAJB6/UBXN1/USP47/TNFAIP8/CAST 24 GO:0090110 COPII-coated vesicle cargo loading 5/770 15/18722 0.000247176191757118 0.00969825955532063 TBC1D20/RAB1A/SAR1A/INSIG1/SEC31A 5 GO:1903543 positive regulation of exosomal secretion 5/770 15/18722 0.000247176191757118 0.00969825955532063 SDC1/VPS4B/TSG101/RAB7A/CHMP2A 5 GO:0140112 extracellular vesicle biogenesis 6/770 23/18722 0.000262672216946294 0.0102257473206514 RAB11A/SDC1/VPS4B/TSG101/RAB7A/CHMP2A 6 GO:1901185 negative regulation of ERBB signaling pathway 7/770 32/18722 0.000264867716261524 0.0102312855048928 EGFR/MVP/DUSP3/TSG101/SNX6/RAB7A/ERRFI1 7 GO:0051452 intracellular pH reduction 8/770 42/18722 0.000268973948290488 0.0102961773924812 BCL2/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/ATP6V0E1/RAB7A/TMEM106B 8 GO:0007163 establishment or maintenance of cell polarity 21/770 218/18722 0.000270680160227783 0.0102961773924812 RHOBTB1/PRKCZ/GATA3/HES1/SNX27/RAP1B/ARF4/OPHN1/DLG5/LMNA/SPINT2/CAP2/NUMA1/RICTOR/MAP7/KANK1/SLC9A1/HSP90AA1/PAFAH1B1/MPP7/RHOBTB3 21 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 12/770 90/18722 0.000309841069563222 0.0116965003760116 DAB2/HERPUD1/HECTD1/VCP/CEBPA/MDM2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/NFE2L2 12 GO:0098927 vesicle-mediated transport between endosomal compartments 8/770 43/18722 0.000318685705901926 0.0119399313722503 DAB2/EZR/HOOK3/EEA1/RAB21/RAB5A/HOOK2/RAB7A 8 GO:0006891 intra-Golgi vesicle-mediated transport 7/770 33/18722 0.00032436214676236 0.0120619147560958 NAPA/GOLGA5/GABARAPL2/CUX1/GOSR1/COPB2/COPB1 7 GO:0072001 renal system development 26/770 302/18722 0.000326903240588458 0.0120663618359429 ARID5B/GATA3/BASP1/ARG2/TFAP2A/OVOL1/C1GALT1/AKR1B1/SDC1/HES1/BCL2/LGR4/DACT2/GLI3/MME/MTSS1/FMN1/DLG5/CTNNB1/RDH10/ENPEP/NRP1/GPC3/SERPINF1/PBX1/ADAMTS6 26 GO:1903077 negative regulation of protein localization to plasma membrane 6/770 24/18722 0.000338132047536154 0.0123890587711225 DAB2/HECTD1/PPFIA1/TMBIM1/TMEM59/AP2M1 6 GO:0001657 ureteric bud development 12/770 91/18722 0.000343802056791099 0.0125048587517522 GATA3/BASP1/ARG2/SDC1/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 12 GO:0015711 organic anion transport 29/770 354/18722 0.000350197565375992 0.012645177306294 SLC26A2/ANXA1/SLC22A11/SLC2A1/KMO/SLC52A1/SLC19A2/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC6A8/SLC19A1/CYB5R1/SLC7A5/SLC5A6/SLC52A3/SLC25A5/CLN3/PNPLA8/GLTP/CLN8/SLC7A6/SLC4A2/SLC16A3/SLC2A8/SLC35B4/SLC13A3 29 GO:0001655 urogenital system development 28/770 338/18722 0.000367766884394931 0.0131080888936935 ANXA1/ARID5B/GATA3/BASP1/ARG2/TFAP2A/OVOL1/C1GALT1/AKR1B1/SDC1/HES1/BCL2/LGR4/DACT2/GLI3/MME/MTSS1/FMN1/GATA2/DLG5/CTNNB1/RDH10/ENPEP/NRP1/GPC3/SERPINF1/PBX1/ADAMTS6 28 GO:1902850 microtubule cytoskeleton organization involved in mitosis 16/770 147/18722 0.000368278636387134 0.0131080888936935 TACC2/RAB11A/GNAI1/SBDS/GOLGA2/VCP/CCSAP/DCTN6/CHMP2B/NUMA1/VPS4B/HSPA1B/TACC1/CHMP4B/PAFAH1B1/CHMP2A 16 GO:0008333 endosome to lysosome transport 9/770 55/18722 0.000373664597262943 0.013205465873484 ARL8B/SNX27/VCP/HOOK3/CHMP2B/VPS4B/TSG101/HOOK2/RAB7A 9 GO:0072163 mesonephric epithelium development 12/770 92/18722 0.000380860997501388 0.0132467030072019 GATA3/BASP1/ARG2/SDC1/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 12 GO:0072164 mesonephric tubule development 12/770 92/18722 0.000380860997501388 0.0132467030072019 GATA3/BASP1/ARG2/SDC1/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 12 GO:0051962 positive regulation of nervous system development 24/770 272/18722 0.000382806589010049 0.0132467030072019 EGFR/EIF4G2/RAB11A/GOLGA4/SPINT1/HES1/TGM2/GLI3/MME/SEMA7A/DHX36/ID2/DLG5/RAB21/CTNNB1/SYNJ1/LRP1/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/RHEB 24 GO:0016055 Wnt signaling pathway 34/770 444/18722 0.000395830865560815 0.0136029324351003 DAB2/UBE2B/EGFR/GATA3/APP/ZNF703/SIAH2/SDC1/DDIT3/LGR4/GLI3/PLPP3/HBP1/VCP/BCL9L/JUP/UBR5/DVL3/LATS2/TNKS2/DDB1/DDX3X/CTNNB1/DLX5/GSKIP/CSNK1A1/LRP1/RAB5A/KANK1/CSNK1E/GPC3/USP8/USP47/FERMT2 34 GO:0061025 membrane fusion 17/770 163/18722 0.000405103813267183 0.0136282429346431 ANXA1/CTSL/VAV3/ARL8B/DYSF/EEA1/SYT7/CLN3/NAPA/CHMP2B/UVRAG/STX5/RAB7A/SNAP23/GOSR1/SPESP1/MYOF 17 GO:0006906 vesicle fusion 13/770 106/18722 0.000407112167204261 0.0136282429346431 ANXA1/VAV3/ARL8B/DYSF/EEA1/SYT7/CLN3/CHMP2B/UVRAG/STX5/RAB7A/SNAP23/GOSR1 13 GO:0043254 regulation of protein-containing complex assembly 33/770 427/18722 0.000407507163809315 0.0136282429346431 PRKCZ/TFRC/CLIP1/RASA1/SCIN/SPIRE2/VCP/AKAP9/FMN1/RAP1B/WASL/HSPA5/JMY/CDC42EP4/SAR1A/NAPA/SNX9/ARF1/NUMA1/DDX3X/FNIP1/RICTOR/SAR1B/HSPA1B/KANK1/CAMSAP2/HSP90AA1/ARHGAP18/MPP7/PSMC6/HSPA8/FERMT2/IQGAP2 33 GO:0048568 embryonic organ development 33/770 427/18722 0.000407507163809315 0.0136282429346431 TBX3/PHLDA2/CEBPB/GATA3/TFAP2A/SPINT1/HES1/EPAS1/GLI3/GCM1/MBD3/HECTD1/TEAD3/GATA2/KRT8/ID2/MIB1/CEBPA/SPINT2/CTNNB1/DLX5/TBC1D23/EIF4A3/MYO6/PPP1R13L/RDH10/INSIG1/DNAJB6/PBX1/RBBP6/ADM/EFEMP1/SOD1 33 GO:0198738 cell-cell signaling by wnt 34/770 446/18722 0.000429211989923444 0.0142568541756352 DAB2/UBE2B/EGFR/GATA3/APP/ZNF703/SIAH2/SDC1/DDIT3/LGR4/GLI3/PLPP3/HBP1/VCP/BCL9L/JUP/UBR5/DVL3/LATS2/TNKS2/DDB1/DDX3X/CTNNB1/DLX5/GSKIP/CSNK1A1/LRP1/RAB5A/KANK1/CSNK1E/GPC3/USP8/USP47/FERMT2 34 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 17/770 164/18722 0.000435064886431877 0.0142568541756352 DAB2/RYBP/GNA12/HERPUD1/HECTD1/VCP/CEBPA/MDM2/CDK2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/UBXN1/COMMD1/NFE2L2 17 GO:2001242 regulation of intrinsic apoptotic signaling pathway 17/770 164/18722 0.000435064886431877 0.0142568541756352 HSPB1/NUPR1/SIAH1/PMAIP1/PTTG1IP/BCL2/DDIT3/HERPUD1/P4HB/MDM2/DDX3X/UBQLN1/MIF/DNAJA1/USP47/SOD1/NFE2L2 17 GO:0061912 selective autophagy 10/770 68/18722 0.000437766554478827 0.0142568541756352 SQSTM1/HSPB8/MAP1LC3B/ATG2A/SLC25A5/LGALS8/RAB7A/TBK1/UBQLN1/UBA5 10 GO:0051180 vitamin transport 8/770 45/18722 0.000440609179820956 0.0142568541756352 SLC2A1/SLC52A1/SLC19A2/SLC19A3/SLC19A1/SLC5A6/SLC52A3/SLC2A8 8 GO:0030705 cytoskeleton-dependent intracellular transport 19/770 195/18722 0.00045136862432172 0.0144711894182251 PRKCZ/HSPB1/APP/ARL8B/MYO10/HOOK3/WASL/CLN3/RAB1A/SYNE2/RAB21/HOOK2/MYO6/CCDC186/ARMCX3/PAFAH1B1/ACTN4/HSPA8/SOD1 19 GO:0045931 positive regulation of mitotic cell cycle 14/770 121/18722 0.00045304145078128 0.0144711894182251 ANXA1/EGFR/RAB11A/APP/HES1/MDM2/DUSP3/DDX3X/PPP1R10/VPS4B/BRD4/PBX1/PAFAH1B1/CCND3 14 GO:0045927 positive regulation of growth 23/770 259/18722 0.000458901142364413 0.0145649961299482 EGFR/EIF4G2/BASP1/RAB11A/NEDD4L/EZR/GOLGA4/HOPX/BCL2/SEMA7A/GHR/SERP1/PPARD/DDX3X/PPIB/LRP1/SLC9A1/MAP3K13/NRP1/PAFAH1B1/TGFBR3/CDKL5/USP47 23 GO:0030641 regulation of cellular pH 11/770 81/18722 0.000465284339663567 0.0146284551394789 BCL2/MAFG/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/SLC4A2/ATP6V0E1/RAB7A/SLC9A1/TMEM106B 11 GO:1905898 positive regulation of response to endoplasmic reticulum stress 7/770 35/18722 0.00047534346988101 0.0146284551394789 PMAIP1/DDIT3/ERN1/HERPUD1/TMEM33/UBQLN1/NFE2L2 7 GO:0006901 vesicle coating 5/770 17/18722 0.000475578914829538 0.0146284551394789 SAR1A/TMED9/SAR1B/PDCD6/TFG 5 GO:1903358 regulation of Golgi organization 5/770 17/18722 0.000475578914829538 0.0146284551394789 EHD3/AKAP9/PDE4DIP/STX5/CAMSAP2 5 GO:1903541 regulation of exosomal secretion 5/770 17/18722 0.000475578914829538 0.0146284551394789 SDC1/VPS4B/TSG101/RAB7A/CHMP2A 5 GO:0030953 astral microtubule organization 4/770 10/18722 0.000488754466557548 0.0149414939070936 RAB11A/EZR/LIMK2/NUMA1 4 GO:0007044 cell-substrate junction assembly 12/770 95/18722 0.000512902535752642 0.0154414731365374 BCL2/FMN1/PHLDB2/PDPK1/ITGB4/DUSP3/LRP1/SLK/SLC9A1/NRP1/SORBS1/FERMT2 12 GO:0030516 regulation of axon extension 12/770 95/18722 0.000512902535752642 0.0154414731365374 SEMA6A/EIF4G2/RAB11A/GOLGA4/SEMA7A/DIP2B/RAB21/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 12 GO:0045851 pH reduction 8/770 46/18722 0.00051440588815276 0.0154414731365374 BCL2/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/ATP6V0E1/RAB7A/TMEM106B 8 GO:0046755 viral budding 6/770 26/18722 0.000539164123600358 0.0159919930232178 CHMP2B/VPS4B/TSG101/VPS37A/CHMP4B/CHMP2A 6 GO:1904376 negative regulation of protein localization to cell periphery 6/770 26/18722 0.000539164123600358 0.0159919930232178 DAB2/HECTD1/PPFIA1/TMBIM1/TMEM59/AP2M1 6 GO:0032273 positive regulation of protein polymerization 15/770 138/18722 0.000563602962421054 0.0164551591415721 CLIP1/SCIN/SPIRE2/AKAP9/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/RICTOR/HSPA1B/HSP90AA1/IQGAP2 15 GO:0001823 mesonephros development 12/770 96/18722 0.00056468637632126 0.0164551591415721 GATA3/BASP1/ARG2/SDC1/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 12 GO:0010769 regulation of cell morphogenesis involved in differentiation 12/770 96/18722 0.00056468637632126 0.0164551591415721 FBLN1/DHX36/P4HB/RAB21/CALR/KANK1/NRP1/CUX1/PAFAH1B1/CDKL5/ACTN4/FERMT2 12 GO:0090174 organelle membrane fusion 13/770 110/18722 0.000583752656976809 0.0169118574983456 ANXA1/VAV3/ARL8B/DYSF/EEA1/SYT7/CLN3/CHMP2B/UVRAG/STX5/RAB7A/SNAP23/GOSR1 13 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 8/770 47/18722 0.000597896745362307 0.0172214998967652 HMOX1/CEBPB/ATF3/DDIT3/EPAS1/HSPA5/DNAJB1/NFE2L2 8 GO:0007160 cell-matrix adhesion 21/770 233/18722 0.000657433541308016 0.0188275364157347 PRKCZ/RASA1/LYPD3/SERPINE1/CD63/BCL2/FMN1/JUP/PHLDB2/PPFIA1/PDPK1/ITGB4/DUSP3/CTNNB1/LRP1/SLK/SLC9A1/UTRN/NRP1/SORBS1/FERMT2 21 GO:0071985 multivesicular body sorting pathway 7/770 37/18722 0.000677620699919554 0.0192947654154236 VCP/LEPROT/CHMP2B/UVRAG/VPS4B/CHMP4B/CHMP2A 7 GO:0060560 developmental growth involved in morphogenesis 21/770 234/18722 0.00069506789366779 0.0196791097394693 PRKCZ/SEMA6A/EIF4G2/RAB11A/NEDD4L/GOLGA4/APP/SPAG9/SEMA7A/FMN1/DIP2B/RAB21/KDM5B/CTNNB1/LRP1/RDH10/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5 21 GO:0031346 positive regulation of cell projection organization 28/770 353/18722 0.000729663919010827 0.020541894397915 EPS8L1/EIF4G2/RAB11A/GOLGA4/SEMA7A/CREB3L2/DHX36/WASL/AP2A1/HSPA5/GRIP1/DVL3/TENM3/CDC42EP4/RAPGEF1/AKIRIN1/RAB21/ATF1/LRP1/MIEN1/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/TMEM106B/NFE2L2 28 GO:0034975 protein folding in endoplasmic reticulum 4/770 11/18722 0.000743108192233892 0.0205717117883416 HSPA5/P4HB/PDIA3/CALR 4 GO:1902188 positive regulation of viral release from host cell 4/770 11/18722 0.000743108192233892 0.0205717117883416 CHMP2B/DDB1/TSG101/CHMP2A 4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 4/770 11/18722 0.000743108192233892 0.0205717117883416 CEBPB/ATF3/DDIT3/HSPA5 4 GO:1990138 neuron projection extension 17/770 172/18722 0.00075150086741529 0.0206891095156375 PRKCZ/SEMA6A/EIF4G2/RAB11A/NEDD4L/GOLGA4/SPAG9/SEMA7A/DIP2B/RAB21/CTNNB1/LRP1/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5 17 GO:1902600 proton transmembrane transport 16/770 157/18722 0.000763704901637749 0.020909568817917 ATP6V1G1/ATP6V1E1/ATP6V1D/ATP6V0A1/CLCN3/ATP6V0D1/SLC25A5/ATP6V0B/ATP6V0E1/ATP6V1C1/SLC9A1/COX4I1/COX17/COX7B/COX6A1/ACTN4 16 GO:0022411 cellular component disassembly 33/770 443/18722 0.000772113984715447 0.0210242840756124 SQSTM1/MAP1LC3B/GABARAPL1/SCIN/ATG9B/ETF1/MAP1LC3A/ATG2A/GOLGA2/VCP/CCSAP/SLC25A5/FURIN/DEDD2/ATXN7/CLN3/NAPA/CHMP2B/UVRAG/DUSP3/VPS4B/SYNJ1/LRP1/TSG101/STX5/UBQLN1/CAMSAP2/GABARAPL2/PAFAH1B1/UBA5/HSPA8/TAOK1/CHMP2A 33 GO:2000117 negative regulation of cysteine-type endopeptidase activity 11/770 86/18722 0.000779838499355501 0.0211192132733069 SIAH2/IFI6/HERPUD1/SERPINB9/MDM2/DDX3X/FNIP1/DNAJB6/USP47/TNFAIP8/CAST 11 GO:0001952 regulation of cell-matrix adhesion 14/770 128/18722 0.000799493371754071 0.0213791107452218 PRKCZ/RASA1/SERPINE1/BCL2/FMN1/JUP/PHLDB2/DUSP3/LRP1/SLK/SLC9A1/UTRN/NRP1/FERMT2 14 GO:0060828 regulation of canonical Wnt signaling pathway 22/770 253/18722 0.000800319483379371 0.0213791107452218 DAB2/UBE2B/EGFR/ZNF703/SIAH2/DDIT3/LGR4/GLI3/VCP/JUP/UBR5/LATS2/TNKS2/DDX3X/DLX5/GSKIP/CSNK1A1/KANK1/CSNK1E/GPC3/USP8/USP47 22 GO:0006694 steroid biosynthetic process 17/770 173/18722 0.000802306584257771 0.0213791107452218 CGA/CYP19A1/HSD17B1/CYP11A1/HSD11B2/FDX1/AKR1B1/CYB5R1/ABCG1/IDI1/PRLR/ACBD3/OSBP/INSIG1/PBX1/ADM/SOD1 17 GO:0048041 focal adhesion assembly 11/770 87/18722 0.000860218645541957 0.0227400211967798 BCL2/FMN1/PHLDB2/PDPK1/DUSP3/LRP1/SLK/SLC9A1/NRP1/SORBS1/FERMT2 11 GO:0007040 lysosome organization 10/770 74/18722 0.00086706883953204 0.0227400211967798 ARL8B/HOOK3/SYT7/CLN3/CLN8/CHMP2B/ARF1/HOOK2/RAB7A/TMEM106B 10 GO:0080171 lytic vacuole organization 10/770 74/18722 0.00086706883953204 0.0227400211967798 ARL8B/HOOK3/SYT7/CLN3/CLN8/CHMP2B/ARF1/HOOK2/RAB7A/TMEM106B 10 GO:0150115 cell-substrate junction organization 12/770 101/18722 0.000894196629236028 0.0233287005417965 BCL2/FMN1/PHLDB2/PDPK1/ITGB4/DUSP3/LRP1/SLK/SLC9A1/NRP1/SORBS1/FERMT2 12 GO:1904036 negative regulation of epithelial cell apoptotic process 8/770 50/18722 0.000915914877873433 0.0235875338632212 NUPR1/HMOX1/GATA3/SERPINE1/GATA2/PDPK1/NFE2L2/CAST 8 GO:0046847 filopodium assembly 9/770 62/18722 0.000923052198139301 0.0235875338632212 EZR/FGD6/MYO10/WASL/CLN3/ITGB4/MIEN1/RAB5A/NRP1 9 GO:0060675 ureteric bud morphogenesis 9/770 62/18722 0.000923052198139301 0.0235875338632212 GATA3/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 9 GO:1903078 positive regulation of protein localization to plasma membrane 9/770 62/18722 0.000923052198139301 0.0235875338632212 SQSTM1/EGFR/RAB11A/EZR/RER1/CLN3/PDPK1/LRP1/SORBS1 9 GO:0032506 cytokinetic process 7/770 39/18722 0.000942670474832261 0.0239659539596385 SPIRE2/SNX9/CHMP2B/ARF1/VPS4B/CHMP4B/CHMP2A 7 GO:0051453 regulation of intracellular pH 10/770 75/18722 0.00096431503623975 0.0242685950787004 BCL2/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/SLC4A2/ATP6V0E1/RAB7A/SLC9A1/TMEM106B 10 GO:0061333 renal tubule morphogenesis 10/770 75/18722 0.00096431503623975 0.0242685950787004 GATA3/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/GPC3/PBX1 10 GO:1901215 negative regulation of neuron death 19/770 208/18722 0.000992410680795201 0.0248501629266457 HMOX1/CEBPB/RASA1/BCL2/CPEB4/CD200/GHR/PSMC1/ERBB3/CLN3/PDPK1/CTNNB1/LRP1/SNX6/NRP1/CHMP4B/SERPINF1/SOD1/HSPD1 19 GO:1903902 positive regulation of viral life cycle 6/770 29/18722 0.00100143927228454 0.0249508594689694 KPNA6/P4HB/CHMP2B/DDB1/TSG101/CHMP2A 6 GO:0072171 mesonephric tubule morphogenesis 9/770 63/18722 0.00103831729120293 0.0257409704580309 GATA3/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 9 GO:1903828 negative regulation of cellular protein localization 13/770 117/18722 0.00104831080540476 0.0258600630858015 DAB2/NEDD4L/HECTD1/LEPROT/LATS2/PPFIA1/ERLEC1/TMBIM1/INSIG1/TMEM59/DNAJA1/COMMD1/AP2M1 13 GO:0030004 cellular monovalent inorganic cation homeostasis 12/770 103/18722 0.00106467197011799 0.0261342878182164 NEDD4L/BCL2/MAFG/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/SLC4A2/ATP6V0E1/RAB7A/SLC9A1/TMEM106B 12 GO:0071243 cellular response to arsenic-containing substance 5/770 20/18722 0.00107539426785413 0.0262160950301192 HMOX1/ATF3/VCP/DHX36/DDX3X 5 GO:0090385 phagosome-lysosome fusion 4/770 12/18722 0.00107852688765291 0.0262160950301192 ARL8B/SYT7/CLN3/RAB7A 4 GO:0097352 autophagosome maturation 7/770 40/18722 0.00110265703532023 0.0265436715314044 MAP1LC3B/MAP1LC3A/VCP/CLN3/UVRAG/TSG101/UBQLN1 7 GO:1901998 toxin transport 7/770 40/18722 0.00110265703532023 0.0265436715314044 CD274/ATP6V0A1/HSPA5/ABCG1/NRP1/COPB2/DNAJA1 7 GO:0031589 cell-substrate adhesion 28/770 363/18722 0.00111766810426894 0.0267756738633275 PRKCZ/RASA1/LYPD3/FBLN1/SERPINE1/CD63/BCL2/FMN1/JUP/PHLDB2/P4HB/RAB1A/PPFIA1/PPARD/PDPK1/ITGB4/DUSP3/CTNNB1/LRP1/CALR/SLK/KANK1/SLC9A1/UTRN/NRP1/SORBS1/ACTN4/FERMT2 28 GO:0006413 translational initiation 13/770 118/18722 0.0011348097960815 0.0270562546118379 HSPB1/EIF4G2/EIF1/EIF2AK1/EIF5/PAIP2/EIF2S2/DDX3X/EIF2B2/EIF4H/AGO2/EIF4A1/EIF3J 13 GO:0002028 regulation of sodium ion transport 11/770 90/18722 0.00114351842665127 0.0271340586666823 FXYD3/NEDD4L/KLHL24/PRSS8/MLLT6/ARF1/SLC9A1/UTRN/STOM/COMMD1/ACTN4 11 GO:0050767 regulation of neurogenesis 28/770 364/18722 0.00116488177381941 0.0273847266240336 SEMA6A/EGFR/EIF4G2/RAB11A/GOLGA4/SPINT1/HES1/TGM2/GLI3/MME/SEMA7A/DHX36/HOOK3/ID2/DIP2B/BHLHE40/RAB21/CTNNB1/LDLR/SYNJ1/LRP1/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/RHEB 28 GO:0070507 regulation of microtubule cytoskeleton organization 15/770 148/18722 0.00116574984007523 0.0273847266240336 CLIP1/GNAI1/AKAP9/CCSAP/ATXN7/PHLDB2/CHMP2B/NUMA1/VPS4B/HSPA1B/CAMSAP2/CHMP4B/PAFAH1B1/TAOK1/CHMP2A 15 GO:0048732 gland development 32/770 436/18722 0.00117577132479209 0.0273847266240336 CGA/TBX3/ANXA1/ARID5B/HMOX1/EGFR/CEBPB/GATA3/ZNF703/HES1/BCL2/TGM2/GLI3/ELF3/KRT18/GATA2/ID2/CEBPA/IRF6/SRSF5/IRS2/KDM5B/CTNNB1/PRLR/CDO1/NRP1/ACO2/LSR/SERPINF1/PBX1/TGFBR3/SOD1 32 GO:1902903 regulation of supramolecular fiber organization 29/770 382/18722 0.00117606492023745 0.0273847266240336 CLIP1/RASA1/SCIN/APP/MTSS1/SPIRE2/AKAP9/FMN1/WASL/ATXN7/PHLDB2/JMY/PPFIA1/CDC42EP4/SNX9/ARF1/NUMA1/LDLR/RICTOR/HSPA1B/KANK1/SLC9A1/NRP1/CAMSAP2/ARHGAP18/HSPA8/TAOK1/FERMT2/IQGAP2 29 GO:0048260 positive regulation of receptor-mediated endocytosis 8/770 52/18722 0.00119443550668405 0.0276831261851471 DAB2/SERPINE1/CD63/WASL/AP2A1/RAB21/SYNJ1/AP2M1 8 GO:0098656 anion transmembrane transport 21/770 245/18722 0.00124862995710908 0.0286517797581082 SLC26A2/SLC13A4/TCAF1/SLC43A2/SLC3A2/SLC38A9/SLC6A8/GABRE/SLC19A1/SLC7A5/SLC5A6/CLCN3/SLC25A5/CLN8/SLC4A2/SLC12A4/SLC16A3/SLC9A1/SLC20A1/SLC35B4/SLC13A3 21 GO:0006885 regulation of pH 11/770 91/18722 0.00125347942750704 0.0286517797581082 BCL2/MAFG/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/SLC4A2/ATP6V0E1/RAB7A/SLC9A1/TMEM106B 11 GO:0042147 retrograde transport, endosome to Golgi 11/770 91/18722 0.00125347942750704 0.0286517797581082 RAB9A/SPAG9/ERC1/EHD3/VPS26A/TBC1D23/STX5/SNX6/RAB7A/GOSR1/RHOBTB3 11 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 10/770 78/18722 0.0013109427159217 0.0298284363170678 SIAH2/IFI6/HERPUD1/SERPINB9/MDM2/DDX3X/FNIP1/DNAJB6/USP47/TNFAIP8 10 GO:0048675 axon extension 13/770 120/18722 0.00132573540440785 0.0300279069098378 SEMA6A/EIF4G2/RAB11A/GOLGA4/SEMA7A/DIP2B/RAB21/LRP1/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5 13 GO:0007566 embryo implantation 8/770 53/18722 0.00135696129669781 0.0304582799164197 FBLN1/PPARD/ITGB4/BSG/CALR/PRLR/AGO2/SOD1 8 GO:0043620 regulation of DNA-templated transcription in response to stress 8/770 53/18722 0.00135696129669781 0.0304582799164197 HMOX1/CEBPB/ATF3/DDIT3/EPAS1/HSPA5/DNAJB1/NFE2L2 8 GO:0032868 response to insulin 22/770 264/18722 0.00139326361947634 0.0311328816854287 PRKCZ/SLC2A1/HSD11B2/PIK3C2A/HDAC5/GHR/SOCS1/GGH/FOXO4/PDPK1/SRSF5/SYAP1/IRS2/KANK1/SLC9A1/STXBP3/INSIG1/SORBS1/SLC2A8/ERRFI1/ADM/CCND3 22 GO:0006446 regulation of translational initiation 10/770 79/18722 0.00144679416441548 0.0319641877011569 HSPB1/EIF4G2/EIF1/EIF2AK1/EIF5/PAIP2/DDX3X/EIF2B2/EIF4H/AGO2 10 GO:0032509 endosome transport via multivesicular body sorting pathway 6/770 31/18722 0.00144740712879328 0.0319641877011569 VCP/LEPROT/CHMP2B/VPS4B/CHMP4B/CHMP2A 6 GO:1903532 positive regulation of secretion by cell 23/770 282/18722 0.00145878102402799 0.0319641877011569 CYP19A1/KMO/EGFR/RAB9A/EZR/KCNN4/SDC1/SERP1/GATA2/SYT7/ABCG1/PPARD/ARF1/IRS2/C1QTNF1/VPS4B/DYNLL1/LRP1/TSG101/RAB5A/RAB7A/OSBP/CHMP2A 23 GO:0060999 positive regulation of dendritic spine development 7/770 42/18722 0.00148603244394143 0.0319641877011569 EIF4G2/C21orf91/DHX36/DLG5/ARF1/PAFAH1B1/CDKL5 7 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 12/770 107/18722 0.00148706315712127 0.0319641877011569 DAB2/HERPUD1/HECTD1/VCP/CEBPA/MDM2/DDA1/CSNK1A1/HSPA1B/CSNK1E/UBQLN1/NFE2L2 12 GO:0006995 cellular response to nitrogen starvation 4/770 13/18722 0.00150744212517999 0.0319641877011569 MAP1LC3B/GABARAPL1/MAP1LC3A/GABARAPL2 4 GO:0021819 layer formation in cerebral cortex 4/770 13/18722 0.00150744212517999 0.0319641877011569 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0043562 cellular response to nitrogen levels 4/770 13/18722 0.00150744212517999 0.0319641877011569 MAP1LC3B/GABARAPL1/MAP1LC3A/GABARAPL2 4 GO:0044794 positive regulation by host of viral process 4/770 13/18722 0.00150744212517999 0.0319641877011569 TBC1D20/PPIB/STOM/HSPA8 4 GO:0048207 vesicle targeting, rough ER to cis-Golgi 4/770 13/18722 0.00150744212517999 0.0319641877011569 SAR1A/SAR1B/PDCD6/TFG 4 GO:0048208 COPII vesicle coating 4/770 13/18722 0.00150744212517999 0.0319641877011569 SAR1A/SAR1B/PDCD6/TFG 4 GO:0060670 branching involved in labyrinthine layer morphogenesis 4/770 13/18722 0.00150744212517999 0.0319641877011569 SPINT1/GCM1/SPINT2/ADM 4 GO:0016125 sterol metabolic process 15/770 152/18722 0.00152576460818956 0.0322156145873244 CYP19A1/CYP11A1/FDX1/APP/CYB5R1/CEBPA/ABCG1/HDLBP/PPARD/CLN8/ACADVL/IDI1/LDLR/INSIG1/SOD1 15 GO:0008202 steroid metabolic process 25/770 319/18722 0.00161971400916529 0.0340549996104246 CGA/CYP19A1/HSD17B1/CYP11A1/HSD11B2/FDX1/APP/AKR1B1/CYB5R1/STS/CEBPA/ABCG1/HDLBP/PPARD/CLN8/ACADVL/IDI1/LDLR/PRLR/ACBD3/OSBP/INSIG1/PBX1/ADM/SOD1 25 GO:0062197 cellular response to chemical stress 26/770 337/18722 0.0016477555195441 0.0344990157726397 ANXA1/HSPB1/HMOX1/SLC2A1/EGFR/AKR1B1/BCL2/DDIT3/EPAS1/MAP1LC3A/OSER1/ERN1/P4HB/CLN3/PNPLA8/MDM2/DDX3X/CTNNB1/GSKIP/HSPA1B/UBQLN1/ERRFI1/DNAJA1/STAU1/SOD1/NFE2L2 26 GO:0040013 negative regulation of locomotion 29/770 391/18722 0.00167373054582077 0.0348962314218615 HMOX1/TCAF1/SEMA6A/GATA3/ARRDC3/FBLN1/SERPINE1/GNA12/BCL2/SEMA7A/CD200/HDAC5/WASL/JUP/PHLDB2/PPARD/DLG5/ADGRG1/SPINT2/DUSP3/DDT/LRP1/CALR/KANK1/NRP1/MIF/SERPINF1/RAP2C/NFE2L2 29 GO:0060713 labyrinthine layer morphogenesis 5/770 22/18722 0.00170617438799468 0.0352774563293671 SPINT1/GCM1/SPINT2/DNAJB6/ADM 5 GO:0140467 integrated stress response signaling 5/770 22/18722 0.00170617438799468 0.0352774563293671 DDIT3/EIF2AK1/HSPA5/TMEM33/NFE2L2 5 GO:1905476 negative regulation of protein localization to membrane 6/770 32/18722 0.00172030083937753 0.0353985813475319 DAB2/HECTD1/PPFIA1/TMBIM1/TMEM59/AP2M1 6 GO:0051222 positive regulation of protein transport 24/770 303/18722 0.00172624027040944 0.0353985813475319 PRKCZ/TCAF1/EGFR/EZR/KCNN4/GLI3/SERP1/JUP/LEPROT/UBR5/ABCG1/CLN3/EDEM1/SAR1A/PPARD/MDM2/ARF1/IRS2/SAR1B/DYNLL1/LRP1/TSG101/OSBP/STOM 24 GO:0010951 negative regulation of endopeptidase activity 21/770 252/18722 0.00176982051839507 0.0361435067342731 SERPINB2/SPINT1/APP/SERPINE1/SIAH2/CRIM1/IFI6/HERPUD1/FURIN/ITIH5/SERPINB9/MDM2/SPINT2/DDX3X/FNIP1/APLP2/SERPINF1/DNAJB6/USP47/TNFAIP8/CAST 21 GO:1902305 regulation of sodium ion transmembrane transport 9/770 68/18722 0.00180197912401782 0.0366500488774725 FXYD3/NEDD4L/KLHL24/ARF1/SLC9A1/UTRN/STOM/COMMD1/ACTN4 9 GO:0097191 extrinsic apoptotic signaling pathway 19/770 219/18722 0.00181456661801832 0.0366647196964714 HMOX1/PMAIP1/ATF3/SERPINE1/SIAH2/BCL2/IFI6/KRT18/KRT8/DEDD2/ERBB3/PDPK1/LMNA/ZDHHC3/DDX3X/PDIA3/HSPA1B/TMBIM1/NRP1 19 GO:0010876 lipid localization 32/770 448/18722 0.00181741636865913 0.0366647196964714 CYP19A1/ANXA1/ATP10D/SLC2A1/GULP1/KCNN4/ARL8B/ABHD5/GRAMD1C/NFKBIA/STARD10/PITPNA/MEST/FURIN/SYT7/ABCG1/CLN3/PLIN2/PNPLA8/HDLBP/PPARD/GLTP/CLN8/IRS2/KDM5B/C1QTNF1/PRELID1/VPS4B/LDLR/LRP1/PNPLA2/OSBP 32 GO:0048762 mesenchymal cell differentiation 20/770 236/18722 0.00184592846049991 0.0370897641881898 TBX3/DAB2/PDCD4/SEMA6A/GATA3/ZNF703/HES1/BCL2/ANXA6/SEMA7A/BCL9L/PHLDB2/ZNF750/DLG5/CTNNB1/RDH10/NRP1/PDCD6/TGFBR3/FERMT2 20 GO:0014812 muscle cell migration 12/770 110/18722 0.00188735618455557 0.0373202216969857 ANXA1/SERPINE1/GNA12/BCL2/P2RY6/PPARD/FOXO4/MDM2/AKIRIN1/LRP1/NRP1/NFE2L2 12 GO:0048259 regulation of receptor-mediated endocytosis 12/770 110/18722 0.00188735618455557 0.0373202216969857 DAB2/SERPINE1/CD63/AAK1/LRPAP1/WASL/AP2A1/OPHN1/RAB21/ARF1/SYNJ1/AP2M1 12 GO:0061387 regulation of extent of cell growth 12/770 110/18722 0.00188735618455557 0.0373202216969857 SEMA6A/EIF4G2/RAB11A/GOLGA4/SEMA7A/DIP2B/RAB21/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 12 GO:1904659 glucose transmembrane transport 12/770 110/18722 0.00188735618455557 0.0373202216969857 SLC2A1/SLC2A12/BRAF/OPN3/PPARD/IRS2/RAB4B/STXBP3/GPC3/SORBS1/SLC2A8/NFE2L2 12 GO:0097193 intrinsic apoptotic signaling pathway 23/770 288/18722 0.00191783451059 0.0377730014477075 HSPB1/NUPR1/HMOX1/SIAH1/PMAIP1/CEBPB/PTTG1IP/BCL2/DDIT3/IFI6/ERN1/HERPUD1/P4HB/JMY/MDM2/DDX3X/GSKIP/UBQLN1/MIF/DNAJA1/USP47/SOD1/NFE2L2 23 GO:1901653 cellular response to peptide 27/770 359/18722 0.00195390594073654 0.0383319421365755 GDF15/PRKCZ/CYP11A1/PIK3C2A/APP/AKR1B1/HDAC5/GHR/SOCS1/RAP1B/LEPROT/FOXO4/PDPK1/MDM2/SRSF5/SYAP1/IRS2/LRP1/SNX6/KANK1/SLC9A1/INSIG1/SORBS1/SLC2A8/ERRFI1/NFE2L2/CCND3 27 GO:0009914 hormone transport 24/770 306/18722 0.00196697554296017 0.0384370161983158 CGA/CYP19A1/TBX3/ANXA1/EGFR/GATA3/PIM3/SLC7A5/SERP1/SYT7/ABCG1/RAB1A/PPARD/IRS2/KDM5B/C1QTNF1/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SNAP23/RAB11FIP1/ADM 24 GO:0008544 epidermis development 25/770 324/18722 0.00200146812390663 0.0389582643024481 ANXA1/MAFF/SVEP1/EGFR/OVOL1/NCOA3/DSP/HES1/BCL2/LGR4/GRHL1/MAFG/STS/OPN3/ZNF750/PPARD/IRF6/LAMC2/NUMA1/CTNNB1/TSG101/MYO6/PAFAH1B1/ERRFI1/SOD1 25 GO:0010810 regulation of cell-substrate adhesion 19/770 221/18722 0.00201350088032249 0.0390399801036847 PRKCZ/RASA1/FBLN1/SERPINE1/BCL2/FMN1/JUP/PHLDB2/P4HB/DUSP3/LRP1/CALR/SLK/KANK1/SLC9A1/UTRN/NRP1/ACTN4/FERMT2 19 GO:0045920 negative regulation of exocytosis 6/770 33/18722 0.00203050943773647 0.039065747213285 ANXA1/HMOX1/RAP1B/VPS4B/RAB7A/STXBP3 6 GO:0046685 response to arsenic-containing substance 6/770 33/18722 0.00203050943773647 0.039065747213285 HMOX1/ATF3/VCP/DHX36/DDX3X/SERPINF1 6 GO:0048284 organelle fusion 14/770 141/18722 0.00203857192198063 0.0390700149508825 ANXA1/TFRC/VAV3/ARL8B/DYSF/EEA1/SYT7/CLN3/CHMP2B/UVRAG/STX5/RAB7A/SNAP23/GOSR1 14 GO:0031929 TOR signaling 13/770 126/18722 0.00206515022739361 0.039427753191963 GATA3/SLC38A9/GNA12/SH3BP4/RRAGC/UBR1/SIK3/SYAP1/FNIP1/RICTOR/AKT1S1/PDCD6/RHEB 13 GO:0071375 cellular response to peptide hormone stimulus 23/770 290/18722 0.00209595695645094 0.0396223191086929 GDF15/PRKCZ/CYP11A1/PIK3C2A/HDAC5/GHR/SOCS1/RAP1B/LEPROT/FOXO4/PDPK1/MDM2/SRSF5/SYAP1/IRS2/KANK1/SLC9A1/INSIG1/SORBS1/SLC2A8/ERRFI1/NFE2L2/CCND3 23 GO:0010888 negative regulation of lipid storage 5/770 23/18722 0.0021071472132859 0.0396223191086929 ABHD5/NFKBIA/ABCG1/PPARD/PNPLA2 5 GO:0045662 negative regulation of myoblast differentiation 5/770 23/18722 0.0021071472132859 0.0396223191086929 TBX3/MBNL3/DDIT3/PPARD/SRA1 5 GO:1902410 mitotic cytokinetic process 5/770 23/18722 0.0021071472132859 0.0396223191086929 CHMP2B/ARF1/VPS4B/CHMP4B/CHMP2A 5 GO:0006869 lipid transport 29/770 398/18722 0.00217759739984674 0.04065335182372 CYP19A1/ANXA1/ATP10D/SLC2A1/GULP1/KCNN4/ARL8B/GRAMD1C/NFKBIA/STARD10/PITPNA/FURIN/SYT7/ABCG1/CLN3/PLIN2/PNPLA8/HDLBP/PPARD/GLTP/CLN8/IRS2/KDM5B/C1QTNF1/PRELID1/VPS4B/LDLR/LRP1/OSBP 29 GO:0007009 plasma membrane organization 14/770 142/18722 0.00217829519103617 0.04065335182372 ANXA6/ARL8B/EPB41L3/MTSS1/DYSF/SERP1/WASL/SYT7/CLN3/SNX9/PLEKHM2/SOD1/SPESP1/MYOF 14 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/770 45/18722 0.0022470326680426 0.0416244006871981 HSPB1/BCL2/P4HB/GSKIP/UBQLN1/SOD1/NFE2L2 7 GO:0071364 cellular response to epidermal growth factor stimulus 7/770 45/18722 0.0022470326680426 0.0416244006871981 EGFR/PDPK1/DUSP3/SYAP1/SNX6/GAREM1/ERRFI1 7 GO:0051047 positive regulation of secretion 24/770 310/18722 0.0023320813705629 0.0430398572944997 CYP19A1/KMO/EGFR/SCIN/RAB9A/EZR/KCNN4/SDC1/SERP1/GATA2/SYT7/ABCG1/PPARD/ARF1/IRS2/C1QTNF1/VPS4B/DYNLL1/LRP1/TSG101/RAB5A/RAB7A/OSBP/CHMP2A 24 GO:0032984 protein-containing complex disassembly 19/770 224/18722 0.00234621190505548 0.0431408631841012 MAP1LC3B/SCIN/ETF1/MAP1LC3A/VCP/CCSAP/ATXN7/CLN3/NAPA/CHMP2B/UVRAG/VPS4B/SYNJ1/TSG101/UBQLN1/CAMSAP2/HSPA8/TAOK1/CHMP2A 19 GO:0030111 regulation of Wnt signaling pathway 25/770 328/18722 0.00235991769184067 0.0432333450678016 DAB2/UBE2B/EGFR/APP/ZNF703/SIAH2/DDIT3/LGR4/GLI3/PLPP3/VCP/JUP/UBR5/LATS2/TNKS2/DDX3X/DLX5/GSKIP/CSNK1A1/LRP1/KANK1/CSNK1E/GPC3/USP8/USP47 25 GO:1990000 amyloid fibril formation 6/770 34/18722 0.00238116670202535 0.0434628339787265 SIAH1/APP/SIAH2/FURIN/MDM2/LDLR 6 GO:0072078 nephron tubule morphogenesis 9/770 71/18722 0.00244186802512876 0.0444081327343672 GATA3/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 9 GO:0030433 ubiquitin-dependent ERAD pathway 10/770 85/18722 0.00252165757415877 0.0454597591576938 HERPUD1/VCP/DNAJB9/HSPA5/EDEM1/ERLEC1/CALR/UBQLN1/PSMC6/NFE2L2 10 GO:0008645 hexose transmembrane transport 12/770 114/18722 0.00255447195298222 0.0454597591576938 SLC2A1/SLC2A12/BRAF/OPN3/PPARD/IRS2/RAB4B/STXBP3/GPC3/SORBS1/SLC2A8/NFE2L2 12 GO:1903008 organelle disassembly 12/770 114/18722 0.00255447195298222 0.0454597591576938 SQSTM1/MAP1LC3B/GABARAPL1/ATG9B/MAP1LC3A/ATG2A/GOLGA2/VCP/SLC25A5/STX5/GABARAPL2/UBA5 12 GO:1902905 positive regulation of supramolecular fiber organization 18/770 209/18722 0.00255903357170437 0.0454597591576938 CLIP1/SCIN/APP/MTSS1/SPIRE2/AKAP9/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/RICTOR/HSPA1B/NRP1/FERMT2/IQGAP2 18 GO:0007035 vacuolar acidification 5/770 24/18722 0.00257267752006214 0.0454597591576938 ATP6V0A1/ATP6V0D1/CLN3/ATP6V0E1/TMEM106B 5 GO:0016486 peptide hormone processing 5/770 24/18722 0.00257267752006214 0.0454597591576938 BACE2/CTSL/MME/FURIN/ENPEP 5 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 5/770 24/18722 0.00257267752006214 0.0454597591576938 CEBPB/ATF3/DDIT3/HSPA5/NFE2L2 5 GO:0070841 inclusion body assembly 5/770 24/18722 0.00257267752006214 0.0454597591576938 VCP/HSPA1B/DNAJB1/DNAJB6/PSMC6 5 GO:0051495 positive regulation of cytoskeleton organization 19/770 226/18722 0.00259275975609957 0.0456527274369051 CLIP1/SCIN/MTSS1/SPIRE2/AKAP9/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/VPS4B/RICTOR/HSPA1B/NRP1/KATNBL1/FERMT2/IQGAP2 19 GO:0046879 hormone secretion 23/770 295/18722 0.00260385390423328 0.0456866338196987 CGA/CYP19A1/TBX3/ANXA1/EGFR/GATA3/PIM3/SERP1/SYT7/ABCG1/RAB1A/PPARD/IRS2/KDM5B/C1QTNF1/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SNAP23/RAB11FIP1/ADM 23 GO:0071453 cellular response to oxygen levels 16/770 177/18722 0.00267646977587698 0.0464667248645329 HMOX1/PMAIP1/BCL2/EPAS1/ATP6V1G1/CPEB4/ATP6V0D1/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/NFE2L2 16 GO:0070227 lymphocyte apoptotic process 9/770 72/18722 0.00269118711190202 0.0464667248645329 LGALS16/ARG2/GLI3/CD274/TNFRSF21/IRS2/FNIP1/PRELID1/KDELR1 9 GO:1903036 positive regulation of response to wounding 9/770 72/18722 0.00269118711190202 0.0464667248645329 ANXA1/ST3GAL4/SERPINE1/PLPP3/LRP1/KANK1/CLDN4/NFE2L2/FERMT2 9 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 4/770 15/18722 0.0026949394914409 0.0464667248645329 TBC1D20/SAR1A/ARF1/SAR1B 4 GO:1905146 lysosomal protein catabolic process 4/770 15/18722 0.0026949394914409 0.0464667248645329 CLN3/LDLR/LRP1/TMEM106B 4 GO:0006767 water-soluble vitamin metabolic process 8/770 59/18722 0.00273576723102251 0.0468464883580247 SLC2A1/SLC52A1/SLC19A2/SLC19A3/SLC19A1/SLC52A3/MTHFS/PDXK 8 GO:0090303 positive regulation of wound healing 8/770 59/18722 0.00273576723102251 0.0468464883580247 ANXA1/ST3GAL4/SERPINE1/PLPP3/KANK1/CLDN4/NFE2L2/FERMT2 8 GO:0045921 positive regulation of exocytosis 10/770 86/18722 0.00275084429452762 0.0469433463001066 RAB9A/SDC1/GATA2/SYT7/ARF1/VPS4B/TSG101/RAB5A/RAB7A/CHMP2A 10 GO:0018105 peptidyl-serine phosphorylation 24/770 315/18722 0.00286808645375942 0.0487770470958471 PRKCZ/TFRC/SGK1/EGFR/TOP1/APP/MAST4/TLK1/BCL2/BRAF/ERN1/AKAP9/LATS2/PDPK1/CDK2/FNIP1/RICTOR/CSNK1A1/RPS6KA5/TBK1/MAP3K13/CSNK1E/MIF/HSP90AA1 24 GO:0016574 histone ubiquitination 7/770 47/18722 0.00290103799975766 0.0490029571281098 UBE2B/OTUB2/RYBP/UBE2A/UBR5/SKP1/DDB1 7 GO:0072583 clathrin-dependent endocytosis 7/770 47/18722 0.00290103799975766 0.0490029571281098 DAB2/AAK1/CLTA/WASL/AP2A1/CLTB/AP2M1 7 GO:0046683 response to organophosphorus 13/770 131/18722 0.00291486411484395 0.0490701617711736 FDX1/EZR/APP/SDC1/AKAP9/RAP1B/P2RY6/HSPA5/RAPGEF1/BSG/CDO1/SOD1/HSPD1 13 GO:0015749 monosaccharide transmembrane transport 12/770 116/18722 0.00295366160216848 0.049499351785749 SLC2A1/SLC2A12/BRAF/OPN3/PPARD/IRS2/RAB4B/STXBP3/GPC3/SORBS1/SLC2A8/NFE2L2 12 GO:0072088 nephron epithelium morphogenesis 9/770 73/18722 0.00296022613529063 0.049499351785749 GATA3/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 9 GO:0006887 exocytosis 26/770 352/18722 0.00299552488882728 0.0498453800653707 ANXA1/HMOX1/PIK3C2A/RAB11A/SCIN/RAB9A/SDC1/ARL8B/RAP1B/GATA2/SYT7/NAPA/PDPK1/RAB21/ARF1/VPS4B/PI4K2A/SYNJ1/TSG101/RAB5A/RAB7A/STXBP3/SNAP23/EXOC6B/RAB11FIP1/CHMP2A 26 GO:1902652 secondary alcohol metabolic process 14/770 147/18722 0.00300092595215958 0.0498453800653707 CYP11A1/FDX1/APP/CEBPA/ABCG1/HDLBP/PPARD/CLN8/ACADVL/IDI1/LDLR/ACO2/INSIG1/SOD1 14 GO:0016049 cell growth 33/770 482/18722 0.00304581520549476 0.0504229141826591 PRKCZ/SGK1/SEMA6A/EGFR/EIF4G2/RAB11A/NEDD4L/GOLGA4/APP/SPAG9/BCL2/EPB41L3/SH3BP4/SEMA7A/BTG1/SERTAD3/DIP2B/PPARD/RAB21/EGLN2/DDX3X/CTNNB1/RBBP7/HSPA1B/LRP1/TSG101/SLC9A1/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5/USP47 33 GO:0001763 morphogenesis of a branching structure 17/770 196/18722 0.00308837415104579 0.0507254399318307 TBX3/SPINT1/BCL2/TGM2/LGR4/GLI3/GCM1/DLG5/SPINT2/KDM5B/CTNNB1/RDH10/MAP3K13/NRP1/GPC3/PBX1/ADM 17 GO:0048143 astrocyte activation 5/770 25/18722 0.00310845813775933 0.0507254399318307 EGFR/BACE2/APP/LDLR/LRP1 5 GO:0060706 cell differentiation involved in embryonic placenta development 5/770 25/18722 0.00310845813775933 0.0507254399318307 GCM1/HECTD1/KRT8/SPINT2/DNAJB6 5 GO:0140448 signaling receptor ligand precursor processing 5/770 25/18722 0.00310845813775933 0.0507254399318307 BACE2/CTSL/MME/FURIN/ENPEP 5 GO:0035264 multicellular organism growth 13/770 132/18722 0.00311498788262897 0.0507254399318307 GDF15/ARID5B/EZR/APP/BCL2/GHR/STK40/TNKS2/GIGYF2/PPIB/PPP1R13L/RBBP6/SOD1 13 GO:0014074 response to purine-containing compound 14/770 148/18722 0.00319266076984005 0.0518209401176318 FDX1/EZR/APP/SDC1/AKAP9/RAP1B/P2RY6/HSPA5/RAPGEF1/XRN1/BSG/CDO1/SOD1/HSPD1 14 GO:0070972 protein localization to endoplasmic reticulum 9/770 74/18722 0.00325004791470337 0.0524841552033387 HERPUD1/HSPA5/RER1/KDELR2/EDEM1/KDELR1/GABARAPL2/CHMP4B/INSIG1 9 GO:0042594 response to starvation 17/770 197/18722 0.00325458638527627 0.0524841552033387 PMAIP1/SLC2A1/MAP1LC3B/GABARAPL1/ATF3/BCL2/DDIT3/EIF2AK1/CPEB4/MAP1LC3A/RRAGC/HSPA5/FNIP1/GABARAPL2/ADM/HSPA8/NFE2L2 17 GO:0032527 protein exit from endoplasmic reticulum 7/770 48/18722 0.00327819157410853 0.0526942858509123 HERPUD1/VCP/EDEM1/SAR1A/ERLEC1/SAR1B/INSIG1 7 GO:1904951 positive regulation of establishment of protein localization 24/770 319/18722 0.00336872808978451 0.0539754728983801 PRKCZ/TCAF1/EGFR/EZR/KCNN4/GLI3/SERP1/JUP/LEPROT/UBR5/ABCG1/CLN3/EDEM1/SAR1A/PPARD/MDM2/ARF1/IRS2/SAR1B/DYNLL1/LRP1/TSG101/OSBP/STOM 24 GO:0040014 regulation of multicellular organism growth 8/770 61/18722 0.003381474820581 0.0540060545863946 GDF15/EZR/APP/BCL2/GHR/TNKS2/PPIB/SOD1 8 GO:0034219 carbohydrate transmembrane transport 12/770 118/18722 0.00340197516945393 0.0541598794549167 SLC2A1/SLC2A12/BRAF/OPN3/PPARD/IRS2/RAB4B/STXBP3/GPC3/SORBS1/SLC2A8/NFE2L2 12 GO:0032271 regulation of protein polymerization 19/770 232/18722 0.00346624359263228 0.0548358788303263 CLIP1/RASA1/SCIN/SPIRE2/AKAP9/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/RICTOR/HSPA1B/KANK1/CAMSAP2/HSP90AA1/ARHGAP18/IQGAP2 19 GO:0001845 phagolysosome assembly 4/770 16/18722 0.0034774508750518 0.0548358788303263 ARL8B/SYT7/CLN3/RAB7A 4 GO:0070230 positive regulation of lymphocyte apoptotic process 4/770 16/18722 0.0034774508750518 0.0548358788303263 LGALS16/CD274/FNIP1/PRELID1 4 GO:0061138 morphogenesis of a branching epithelium 16/770 182/18722 0.00353037223532871 0.0554674963627629 TBX3/SPINT1/BCL2/TGM2/LGR4/GLI3/GCM1/DLG5/SPINT2/KDM5B/CTNNB1/RDH10/NRP1/GPC3/PBX1/ADM 16 GO:0014910 regulation of smooth muscle cell migration 10/770 89/18722 0.00353976797980305 0.0554674963627629 SERPINE1/GNA12/BCL2/P2RY6/PPARD/FOXO4/MDM2/LRP1/NRP1/NFE2L2 10 GO:0030307 positive regulation of cell growth 15/770 166/18722 0.00359438749649207 0.0561468115831348 EGFR/EIF4G2/RAB11A/NEDD4L/GOLGA4/BCL2/SEMA7A/DDX3X/LRP1/SLC9A1/MAP3K13/NRP1/PAFAH1B1/CDKL5/USP47 15 GO:0007162 negative regulation of cell adhesion 23/770 303/18722 0.00363166762984321 0.056487560365123 ANXA1/SEMA6A/CEBPB/RASA1/ARG2/FBLN1/ZNF703/SERPINE1/DACT2/GLI3/SOCS1/CD274/PHLDB2/ERBB3/TNFRSF21/DLG5/CD164/SPINT2/DUSP3/C1QTNF1/LRP1/KANK1/ACTN4 23 GO:0048545 response to steroid hormone 25/770 339/18722 0.00363887354549558 0.056487560365123 ANXA1/DAB2/ESRRG/HSD11B2/EGFR/PGRMC2/SDC1/BCL2/FBXO32/GHR/UBR5/PPARD/MDM2/EGLN2/RBBP7/CALR/CDO1/SERPINF1/ERRFI1/USP8/DNAJA1/UBA5/ADM/CLDN4/HSPD1 25 GO:0032006 regulation of TOR signaling 11/770 104/18722 0.00365579283936013 0.0565739618587935 SLC38A9/GNA12/SH3BP4/RRAGC/UBR1/SIK3/FNIP1/RICTOR/AKT1S1/PDCD6/RHEB 11 GO:0070849 response to epidermal growth factor 7/770 49/18722 0.00369161268949883 0.0566903080344139 EGFR/PDPK1/DUSP3/SYAP1/SNX6/GAREM1/ERRFI1 7 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 6/770 37/18722 0.00370812697165833 0.0566903080344139 NEK7/DHX36/PKIB/TNKS2/CTNNB1/MAP3K4 6 GO:0033598 mammary gland epithelial cell proliferation 5/770 26/18722 0.00372019480779718 0.0566903080344139 CEBPB/GATA3/ZNF703/ID2/KDM5B 5 GO:0060669 embryonic placenta morphogenesis 5/770 26/18722 0.00372019480779718 0.0566903080344139 SPINT1/GCM1/SPINT2/DNAJB6/ADM 5 GO:2000108 positive regulation of leukocyte apoptotic process 5/770 26/18722 0.00372019480779718 0.0566903080344139 ANXA1/LGALS16/CD274/FNIP1/PRELID1 5 GO:0052548 regulation of endopeptidase activity 30/770 432/18722 0.00375125577649674 0.0569893522386685 PMAIP1/SERPINB2/SPINT1/APP/SERPINE1/SIAH2/CRIM1/IFI6/HERPUD1/VCP/FURIN/ITIH5/SERPINB9/MDM2/SPINT2/ADRM1/DDX3X/FNIP1/APLP2/PRELID1/AKIRIN2/SERPINF1/DNAJB6/PDCD6/PSMD14/USP47/TNFAIP8/HSPE1/HSPD1/CAST 30 GO:0055067 monovalent inorganic cation homeostasis 14/770 151/18722 0.00382881794330131 0.0577653040279526 NEDD4L/BCL2/MAFG/ATP6V0A1/CLCN3/ATP6V0D1/CLN3/SLC4A2/MLLT6/SLC12A4/ATP6V0E1/RAB7A/SLC9A1/TMEM106B 14 GO:2001236 regulation of extrinsic apoptotic signaling pathway 14/770 151/18722 0.00382881794330131 0.0577653040279526 HMOX1/PMAIP1/ATF3/SERPINE1/SIAH2/BCL2/IFI6/DEDD2/LMNA/DDX3X/PDIA3/HSPA1B/TMBIM1/NRP1 14 GO:0001558 regulation of cell growth 29/770 414/18722 0.00383710929826456 0.0577653040279526 SGK1/SEMA6A/EGFR/EIF4G2/RAB11A/NEDD4L/GOLGA4/SPAG9/BCL2/EPB41L3/SH3BP4/SEMA7A/BTG1/SERTAD3/DIP2B/PPARD/RAB21/EGLN2/DDX3X/RBBP7/HSPA1B/LRP1/TSG101/SLC9A1/MAP3K13/NRP1/PAFAH1B1/CDKL5/USP47 29 GO:0072028 nephron morphogenesis 9/770 76/18722 0.00389640720652698 0.0584813165967588 GATA3/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 9 GO:0072073 kidney epithelium development 13/770 136/18722 0.00403043059095766 0.0603112181223485 GATA3/BASP1/ARG2/SDC1/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/GPC3/PBX1 13 GO:0008643 carbohydrate transport 14/770 152/18722 0.00406246103526916 0.0606085129902581 SLC2A1/SLC2A12/EZR/BRAF/OPN3/PPARD/IRS2/RAB4B/STXBP3/GPC3/SORBS1/SLC2A8/SLC35B4/NFE2L2 14 GO:0051346 negative regulation of hydrolase activity 27/770 379/18722 0.00412500850134272 0.0613579622751964 ANXA1/PRKCZ/SERPINB2/SPINT1/APP/SERPINE1/SIAH2/CRIM1/IFI6/SH3BP4/HERPUD1/FURIN/ITIH5/SERPINB9/MDM2/SPINT2/DDX3X/FNIP1/APLP2/LRP1/GPC3/SERPINF1/DNAJB6/UBXN1/USP47/TNFAIP8/CAST 27 GO:0072080 nephron tubule development 10/770 91/18722 0.00415853617968035 0.0616725767361524 GATA3/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/GPC3/PBX1 10 GO:0009913 epidermal cell differentiation 17/770 202/18722 0.00420066259149537 0.0620394504574058 ANXA1/MAFF/OVOL1/NCOA3/DSP/HES1/GRHL1/MAFG/OPN3/IRF6/NUMA1/CTNNB1/TSG101/MYO6/PAFAH1B1/ERRFI1/SOD1 17 GO:0006766 vitamin metabolic process 11/770 106/18722 0.00423307508639735 0.0620394504574058 CYP11A1/SLC2A1/SLC52A1/SLC19A2/SLC19A3/SLC19A1/SLC52A3/MTHFS/PPARD/PDXK/RDH10 11 GO:0071887 leukocyte apoptotic process 11/770 106/18722 0.00423307508639735 0.0620394504574058 ANXA1/LGALS16/CTSL/ARG2/GLI3/CD274/TNFRSF21/IRS2/FNIP1/PRELID1/KDELR1 11 GO:1905477 positive regulation of protein localization to membrane 11/770 106/18722 0.00423307508639735 0.0620394504574058 SQSTM1/TCAF1/EGFR/RAB11A/EZR/RER1/CLN3/PDPK1/LRP1/SORBS1/STOM 11 GO:0097242 amyloid-beta clearance 6/770 38/18722 0.0042531132865081 0.0621503328641345 RAB11A/MME/LRPAP1/LDLR/LRP1/RAB5A 6 GO:0008203 cholesterol metabolic process 13/770 137/18722 0.00429030508397534 0.0625104977586232 CYP11A1/FDX1/APP/CEBPA/ABCG1/HDLBP/PPARD/CLN8/ACADVL/IDI1/LDLR/INSIG1/SOD1 13 GO:0031667 response to nutrient levels 32/770 474/18722 0.00430397686096874 0.0625268708402543 GDF15/NUCB2/HMOX1/PMAIP1/SLC2A1/HSD11B2/EGFR/MAP1LC3B/GABARAPL1/ATF3/BCL2/DDIT3/EIF2AK1/CPEB4/MBD3/MAP1LC3A/RRAGC/GHR/KRT18/HSPA5/PPARD/FOXO4/MDM2/FNIP1/LDLR/GABARAPL2/COX4I1/BNIP2/ADM/HSPA8/SOD1/NFE2L2 32 GO:0060644 mammary gland epithelial cell differentiation 4/770 17/18722 0.00440110378588942 0.0626728445676896 CEBPB/ZNF703/ID2/IRF6 4 GO:0061952 midbody abscission 4/770 17/18722 0.00440110378588942 0.0626728445676896 CHMP2B/VPS4B/CHMP4B/CHMP2A 4 GO:0090083 regulation of inclusion body assembly 4/770 17/18722 0.00440110378588942 0.0626728445676896 HSPA1B/DNAJB1/DNAJB6/PSMC6 4 GO:1904355 positive regulation of telomere capping 4/770 17/18722 0.00440110378588942 0.0626728445676896 NEK7/PKIB/TNKS2/MAP3K4 4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 5/770 27/18722 0.00441357430071658 0.0626728445676896 RAB11A/APP/VPS4B/BRD4/PBX1 5 GO:0035459 vesicle cargo loading 5/770 27/18722 0.00441357430071658 0.0626728445676896 TBC1D20/RAB1A/SAR1A/INSIG1/SEC31A 5 GO:0070861 regulation of protein exit from endoplasmic reticulum 5/770 27/18722 0.00441357430071658 0.0626728445676896 EDEM1/SAR1A/ERLEC1/SAR1B/INSIG1 5 GO:0032869 cellular response to insulin stimulus 17/770 203/18722 0.00441464347647181 0.0626728445676896 PRKCZ/PIK3C2A/HDAC5/GHR/SOCS1/FOXO4/PDPK1/SRSF5/SYAP1/IRS2/KANK1/SLC9A1/INSIG1/SORBS1/SLC2A8/ERRFI1/CCND3 17 GO:0001667 ameboidal-type cell migration 32/770 475/18722 0.00443978349301982 0.0628506850730619 ANXA1/ARID5B/HSPB1/S100P/HMOX1/SEMA6A/PIK3C2A/GATA3/RAB11A/EPHB4/GNA12/ANXA6/PLPP3/SEMA7A/HDAC5/GATA2/JUP/CLN3/PPARD/PDPK1/ITGB4/LGALS8/CALR/KANK1/NRP1/AGO2/GPC3/SERPINF1/PAFAH1B1/PDCD6/ZFAND5/NFE2L2 32 GO:0036503 ERAD pathway 11/770 107/18722 0.00454772228662689 0.0641963177174555 HERPUD1/VCP/DNAJB9/HSPA5/EDEM1/ERLEC1/CALR/UBQLN1/UBXN1/PSMC6/NFE2L2 11 GO:0045995 regulation of embryonic development 8/770 64/18722 0.00456441620559782 0.0642499603177795 PHLDA2/HES1/DHX36/CCSAP/PHLDB2/CTNNB1/PAFAH1B1/NFE2L2 8 GO:0007346 regulation of mitotic cell cycle 31/770 457/18722 0.00457960621294886 0.0642821908707723 ANXA1/BTG3/CDKN1C/EGFR/NABP1/RAB11A/OVOL1/APP/PIM3/HES1/BCL2/NEK7/BTG1/ID2/FOXO4/MDM2/DUSP3/DDB1/CDK2/DDX3X/PPP1R10/CTNNB1/GIGYF2/VPS4B/BRD4/SRA1/PBX1/PAFAH1B1/USP47/TAOK1/CCND3 31 GO:0060485 mesenchyme development 22/770 291/18722 0.00459972475586728 0.064383226006985 TBX3/DAB2/PDCD4/SEMA6A/GATA3/BASP1/ZNF703/HES1/BCL2/ANXA6/SEMA7A/BCL9L/PHLDB2/ZNF750/DLG5/MDM2/CTNNB1/RDH10/NRP1/PDCD6/TGFBR3/FERMT2 22 GO:0045104 intermediate filament cytoskeleton organization 7/770 51/18722 0.00463596294090266 0.0645279422751899 DSP/KRT18/KLHL24/CLN8/CSNK1A1/DNAJB6/SOD1 7 GO:0045661 regulation of myoblast differentiation 7/770 51/18722 0.00463596294090266 0.0645279422751899 TBX3/MBNL3/DDIT3/BTG1/PPARD/AKIRIN1/SRA1 7 GO:0051591 response to cAMP 10/770 93/18722 0.00485966548221673 0.0670795376672742 FDX1/EZR/APP/SDC1/AKAP9/RAP1B/HSPA5/RAPGEF1/BSG/CDO1 10 GO:0060993 kidney morphogenesis 10/770 93/18722 0.00485966548221673 0.0670795376672742 GATA3/BASP1/HES1/BCL2/LGR4/GLI3/FMN1/CTNNB1/GPC3/PBX1 10 GO:1901992 positive regulation of mitotic cell cycle phase transition 10/770 93/18722 0.00485966548221673 0.0670795376672742 ANXA1/EGFR/RAB11A/APP/MDM2/DDX3X/VPS4B/BRD4/PBX1/CCND3 10 GO:0045682 regulation of epidermis development 8/770 65/18722 0.00502204677957452 0.0687499869733278 MAFF/NCOA3/HES1/GRHL1/MAFG/PPARD/NUMA1/ERRFI1 8 GO:0090307 mitotic spindle assembly 8/770 65/18722 0.00502204677957452 0.0687499869733278 RAB11A/GOLGA2/CCSAP/CHMP2B/VPS4B/HSPA1B/CHMP4B/CHMP2A 8 GO:0007015 actin filament organization 30/770 441/18722 0.00502637872410186 0.0687499869733278 RHOBTB1/RASA1/SCIN/EZR/BCL2/FHDC1/MTSS1/SPIRE2/FMN1/WASL/PHLDB2/TPM4/JMY/PPFIA1/CDC42EP4/SNX9/NEBL/DIAPH2/ARF1/RICTOR/KANK1/MYO6/SLC9A1/NRP1/SORBS1/ARHGAP18/RHOBTB3/GAS2L3/FERMT2/IQGAP2 30 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 9/770 79/18722 0.00504966791736664 0.0687499869733278 DHX36/P4HB/RAB21/CALR/NRP1/CUX1/PAFAH1B1/CDKL5/FERMT2 9 GO:0050772 positive regulation of axonogenesis 9/770 79/18722 0.00504966791736664 0.0687499869733278 EIF4G2/RAB11A/GOLGA4/SEMA7A/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 9 GO:0042326 negative regulation of phosphorylation 27/770 385/18722 0.00508051601051839 0.0689815021264663 PRKCZ/HSPB1/NUPR1/CDKN1C/PDCD4/UBE2B/MLLT1/HEXIM1/FBLN1/SPAG9/PLPP3/SOCS1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/IRS2/GSKIP/DYNLL1/AKT1S1/LRP1/TSG101/SNX6/ERRFI1/DNAJA1 27 GO:0009267 cellular response to starvation 14/770 156/18722 0.00511560350971211 0.0690264580571808 PMAIP1/SLC2A1/MAP1LC3B/GABARAPL1/ATF3/BCL2/CPEB4/MAP1LC3A/RRAGC/HSPA5/FNIP1/GABARAPL2/HSPA8/NFE2L2 14 GO:0007548 sex differentiation 21/770 276/18722 0.00516169950713878 0.0690264580571808 CGA/CYP19A1/TBX3/ARID5B/NUPR1/CEBPB/GATA3/BASP1/SDC1/BCL2/LGR4/HSPA5/TBC1D20/EIF2S2/ADGRG1/CTNNB1/RDH10/EIF2B2/PBX1/RHOBTB3/SOD1 21 GO:1903829 positive regulation of cellular protein localization 21/770 276/18722 0.00516169950713878 0.0690264580571808 SQSTM1/TFRC/TCAF1/EGFR/RAB11A/EZR/GLI3/GNAI1/JUP/LEPROT/RER1/UBR5/LIMK2/CLN3/PDPK1/NUMA1/LRP1/TSG101/SORBS1/STOM/FERMT2 21 GO:0032206 positive regulation of telomere maintenance 7/770 52/18722 0.00517131165289223 0.0690264580571808 NEK7/DHX36/PKIB/TNKS2/PPP1R10/CTNNB1/MAP3K4 7 GO:0045010 actin nucleation 7/770 52/18722 0.00517131165289223 0.0690264580571808 SCIN/SPIRE2/FMN1/WASL/JMY/ARF1/IQGAP2 7 GO:0045103 intermediate filament-based process 7/770 52/18722 0.00517131165289223 0.0690264580571808 DSP/KRT18/KLHL24/CLN8/CSNK1A1/DNAJB6/SOD1 7 GO:0051271 negative regulation of cellular component movement 26/770 367/18722 0.00518079376146611 0.0690264580571808 HMOX1/TCAF1/GATA3/FBLN1/SERPINE1/GNA12/BCL2/CD200/HDAC5/WASL/JUP/PHLDB2/PPARD/DLG5/ADGRG1/SPINT2/DUSP3/DDT/LRP1/CALR/KANK1/MIF/SERPINF1/RAP2C/TGFBR3/NFE2L2 26 GO:0072009 nephron epithelium development 11/770 109/18722 0.00523260050814754 0.0693041883659958 GATA3/BASP1/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/GPC3/PBX1 11 GO:0010389 regulation of G2/M transition of mitotic cell cycle 10/770 94/18722 0.00524336323780462 0.0693041883659958 NABP1/RAB11A/APP/FOXO4/CDK2/VPS4B/BRD4/PBX1/USP47/TAOK1 10 GO:0061326 renal tubule development 10/770 94/18722 0.00524336323780462 0.0693041883659958 GATA3/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/GPC3/PBX1 10 GO:0051960 regulation of nervous system development 30/770 443/18722 0.0053544574412421 0.0705853476976439 SEMA6A/EGFR/EIF4G2/RAB11A/GOLGA4/SPINT1/HES1/TGM2/GLI3/MME/SEMA7A/DHX36/HOOK3/ID2/DIP2B/BHLHE40/TNFRSF21/DLG5/RAB21/CTNNB1/LDLR/SYNJ1/LRP1/MAP3K13/NRP1/SERPINF1/CUX1/PAFAH1B1/CDKL5/RHEB 30 GO:0036499 PERK-mediated unfolded protein response 4/770 18/18722 0.00547675186565331 0.0719268921216321 DDIT3/HSPA5/TMEM33/NFE2L2 4 GO:0009791 post-embryonic development 9/770 80/18722 0.00548772781376883 0.0719268921216321 ARID5B/GATA3/BCL2/SERP1/KDM5B/GIGYF2/PPP1R13L/AGO2/EFEMP1 9 GO:0051893 regulation of focal adhesion assembly 8/770 66/18722 0.00551396202899126 0.0719268921216321 FMN1/PHLDB2/DUSP3/LRP1/SLK/SLC9A1/NRP1/FERMT2 8 GO:0090109 regulation of cell-substrate junction assembly 8/770 66/18722 0.00551396202899126 0.0719268921216321 FMN1/PHLDB2/DUSP3/LRP1/SLK/SLC9A1/NRP1/FERMT2 8 GO:0010001 glial cell differentiation 18/770 225/18722 0.00556264463410132 0.0723724757486342 EGFR/BACE2/SPINT1/APP/HES1/GLI3/GCM1/ID2/ERBB3/GPR157/TNFRSF21/ITGB4/CTNNB1/LDLR/LRP1/EIF2B2/RHEB/SOD1 18 GO:0051258 protein polymerization 22/770 296/18722 0.00560676782998038 0.0727565731687298 CLIP1/RASA1/SCIN/SPIRE2/GOLGA2/AKAP9/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/NUMA1/RICTOR/HSPA1B/KANK1/CAMSAP2/CHMP4B/HSP90AA1/ARHGAP18/CHMP2A/IQGAP2 22 GO:0071320 cellular response to cAMP 7/770 53/18722 0.00575175627231311 0.0744441597530811 FDX1/EZR/APP/AKAP9/RAP1B/HSPA5/RAPGEF1 7 GO:0050729 positive regulation of inflammatory response 13/770 142/18722 0.00579969659975616 0.0748701765714636 NUPR1/PDCD4/EGFR/CEBPB/APP/SERPINE1/TGM2/NFKBIA/CEBPA/NEAT1/DDT/LDLR/HSPD1 13 GO:0031647 regulation of protein stability 22/770 298/18722 0.0060575426583078 0.0773081746522443 SIAH1/UBE2B/MYLIP/NEDD4L/BCL2/AAK1/PLPP3/DVL3/BAG1/MDM2/LMNA/RAB21/PPIB/HSPA1B/CALR/SERF2/HSP90AA1/USP8/USP47/HSPA8/DDOST/HSPD1 22 GO:0032366 intracellular sterol transport 5/770 29/18722 0.0060677328609184 0.0773081746522443 ARL8B/SYT7/ABCG1/LDLR/OSBP 5 GO:0032367 intracellular cholesterol transport 5/770 29/18722 0.0060677328609184 0.0773081746522443 ARL8B/SYT7/ABCG1/LDLR/OSBP 5 GO:0071549 cellular response to dexamethasone stimulus 5/770 29/18722 0.0060677328609184 0.0773081746522443 EGFR/FBXO32/SERPINF1/ERRFI1/USP8 5 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 5/770 29/18722 0.0060677328609184 0.0773081746522443 HSPB1/P4HB/UBQLN1/SOD1/NFE2L2 5 GO:1901655 cellular response to ketone 10/770 96/18722 0.00608163846351189 0.0773081746522443 EGFR/FDX1/AKR1B1/GNAI1/FBXO32/P2RY6/XRN1/SERPINF1/ERRFI1/USP8 10 GO:0031396 regulation of protein ubiquitination 17/770 210/18722 0.00617605713156654 0.0783086327903207 SQSTM1/ARRDC3/OTUB2/PTTG1IP/SIAH2/HERPUD1/HSPA5/UBR5/SKP1/DDX3X/HSPA1B/UBQLN1/HSP90AA1/PDCD6/UBXN1/DNAJA1/COMMD1 17 GO:0006814 sodium ion transport 19/770 245/18722 0.00621361552689085 0.0785848887576068 SLC13A4/SGK1/FXYD3/SLC3A2/SLC38A1/NEDD4L/SLC6A8/SLC5A6/KLHL24/PRSS8/MLLT6/ARF1/SLC9A1/UTRN/SLC20A1/STOM/COMMD1/ACTN4/SLC13A3 19 GO:0043588 skin development 20/770 263/18722 0.00628531956106447 0.0792904996779348 ANXA1/EGFR/ARRDC3/OVOL1/NCOA3/DSP/BCL2/LGR4/DACT2/GRHL1/JUP/OPN3/IRF6/ITGB4/NUMA1/CTNNB1/TSG101/LSR/ERRFI1/CLDN4 20 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 9/770 82/18722 0.00645147083254836 0.0809765218100466 HMOX1/PMAIP1/ATF3/SERPINE1/BCL2/DEDD2/ZDHHC3/DDX3X/TMBIM1 9 GO:0050000 chromosome localization 9/770 82/18722 0.00645147083254836 0.0809765218100466 UBE2B/RAB11A/CHMP2B/LMNA/NUMA1/VPS4B/CHMP4B/EML4/CHMP2A 9 GO:0046718 viral entry into host cell 13/770 144/18722 0.00651083853344968 0.0814483454216444 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/P4HB/CD46/UVRAG/BSG/LDLR/HSPA1B/NRP1 13 GO:0014909 smooth muscle cell migration 10/770 97/18722 0.00653809716408946 0.0814483454216444 SERPINE1/GNA12/BCL2/P2RY6/PPARD/FOXO4/MDM2/LRP1/NRP1/NFE2L2 10 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 10/770 97/18722 0.00653809716408946 0.0814483454216444 HMOX1/SERPINE1/SIAH2/BCL2/IFI6/LMNA/DDX3X/HSPA1B/TMBIM1/NRP1 10 GO:1904888 cranial skeletal system development 8/770 68/18722 0.00660706879070307 0.081598948706522 TFAP2A/GLI3/MSX2/IRF6/CTNNB1/EIF4A3/RDH10/INSIG1 8 GO:0002934 desmosome organization 3/770 10/18722 0.00669405683273188 0.081598948706522 DSP/GRHL1/JUP 3 GO:1904896 ESCRT complex disassembly 3/770 10/18722 0.00669405683273188 0.081598948706522 CHMP2B/VPS4B/CHMP2A 3 GO:1904903 ESCRT III complex disassembly 3/770 10/18722 0.00669405683273188 0.081598948706522 CHMP2B/VPS4B/CHMP2A 3 GO:0007039 protein catabolic process in the vacuole 4/770 19/18722 0.00671466730116258 0.081598948706522 CLN3/LDLR/LRP1/TMEM106B 4 GO:0032616 interleukin-13 production 4/770 19/18722 0.00671466730116258 0.081598948706522 PRKCZ/GATA3/ARG2/TNFRSF21 4 GO:0032656 regulation of interleukin-13 production 4/770 19/18722 0.00671466730116258 0.081598948706522 PRKCZ/GATA3/ARG2/TNFRSF21 4 GO:0035461 vitamin transmembrane transport 4/770 19/18722 0.00671466730116258 0.081598948706522 SLC19A2/SLC19A3/SLC19A1/SLC5A6 4 GO:0036498 IRE1-mediated unfolded protein response 4/770 19/18722 0.00671466730116258 0.081598948706522 ERN1/DNAJB9/HSPA5/TMEM33 4 GO:0044827 modulation by host of viral genome replication 4/770 19/18722 0.00671466730116258 0.081598948706522 TBC1D20/PPIB/STOM/HSPA8 4 GO:0036294 cellular response to decreased oxygen levels 14/770 161/18722 0.0067303166603212 0.081598948706522 HMOX1/PMAIP1/BCL2/EPAS1/CPEB4/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/NFE2L2 14 GO:0006469 negative regulation of protein kinase activity 17/770 212/18722 0.00677250686458311 0.0819111691898486 HSPB1/CDKN1C/PDCD4/MLLT1/HEXIM1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/GSKIP/AKT1S1/TSG101/SNX6/ERRFI1/DNAJA1 17 GO:0042063 gliogenesis 22/770 301/18722 0.00678933272137084 0.0819158473379925 ANXA1/EGFR/BACE2/SPINT1/APP/HES1/GLI3/GCM1/ID2/ERBB3/GPR157/TNFRSF21/ADGRG1/ITGB4/CTNNB1/LDLR/SYNJ1/LRP1/EIF2B2/PAFAH1B1/RHEB/SOD1 22 GO:0018209 peptidyl-serine modification 24/770 338/18722 0.00686277533156813 0.0826019552589468 PRKCZ/TFRC/SGK1/EGFR/TOP1/APP/MAST4/TLK1/BCL2/BRAF/ERN1/AKAP9/LATS2/PDPK1/CDK2/FNIP1/RICTOR/CSNK1A1/RPS6KA5/TBK1/MAP3K13/CSNK1E/MIF/HSP90AA1 24 GO:0043524 negative regulation of neuron apoptotic process 13/770 145/18722 0.00689149418543439 0.0827477482554688 HMOX1/CEBPB/RASA1/BCL2/CPEB4/ERBB3/CLN3/PDPK1/LRP1/SNX6/NRP1/SOD1/HSPD1 13 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 10/770 98/18722 0.00702070824677669 0.0837182599011941 HSPB1/PTTG1IP/BCL2/HERPUD1/MDM2/DDX3X/MIF/DNAJA1/USP47/NFE2L2 10 GO:0072595 maintenance of protein localization in organelle 6/770 42/18722 0.00703585281428923 0.0837182599011941 HSPA5/RER1/KDELR2/SKP1/KDELR1/INSIG1 6 GO:0044788 modulation by host of viral process 5/770 30/18722 0.00703952456323506 0.0837182599011941 TBC1D20/PPIB/PSMC3/STOM/HSPA8 5 GO:1902751 positive regulation of cell cycle G2/M phase transition 5/770 30/18722 0.00703952456323506 0.0837182599011941 RAB11A/APP/VPS4B/BRD4/PBX1 5 GO:0007568 aging 24/770 339/18722 0.00710840594384031 0.0843361590908482 TBX3/PDCD4/KMO/ARG2/APP/SERPINE1/BCL2/MME/MBD3/JUND/SERP1/ID2/FOXO4/CLN8/LMNA/CDK2/LRP1/CALR/MIF/SERPINF1/RPN2/ADM/SOD1/NFE2L2 24 GO:0015807 L-amino acid transport 8/770 69/18722 0.00721150234473417 0.0853560954484807 SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5/CLN8/SLC7A6 8 GO:0002244 hematopoietic progenitor cell differentiation 11/770 114/18722 0.00730364014720308 0.0861874370419697 GATA3/RBM47/PRRC2C/HES1/BCL2/SBDS/ZFAT/DHX36/FNIP1/CHD2/NFE2L2 11 GO:0015849 organic acid transport 22/770 303/18722 0.00731633270494745 0.0861874370419697 SLC26A2/ANXA1/SLC2A1/KMO/SLC19A2/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC19A1/SLC7A5/SLC5A6/CLN3/PLIN2/PNPLA8/PPARD/CLN8/SLC7A6/IRS2/SLC16A3/SLC13A3 22 GO:0043467 regulation of generation of precursor metabolites and energy 12/770 130/18722 0.00737356031275406 0.0866567241472959 NUPR1/PHLDA2/APP/VCP/OPN3/IL10RB/IRS2/PRELID1/SORBS1/GHITM/COX17/PPP1CB 12 GO:2000146 negative regulation of cell motility 25/770 359/18722 0.00745763747750452 0.0874386060009529 HMOX1/TCAF1/GATA3/FBLN1/SERPINE1/GNA12/BCL2/CD200/HDAC5/WASL/JUP/PHLDB2/PPARD/DLG5/ADGRG1/SPINT2/DUSP3/DDT/LRP1/CALR/KANK1/MIF/SERPINF1/RAP2C/NFE2L2 25 GO:0010952 positive regulation of peptidase activity 16/770 197/18722 0.0075185706890159 0.0875820365136218 PMAIP1/FBLN1/APP/VCP/PCOLCE2/ADRM1/DDX3X/PRELID1/AKIRIN2/TANK/CLPX/PDCD6/PSMD14/CLDN4/HSPE1/HSPD1 16 GO:0030838 positive regulation of actin filament polymerization 10/770 99/18722 0.00753043697022535 0.0875820365136218 SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/IQGAP2 10 GO:0006970 response to osmotic stress 9/770 84/18722 0.00754017532898731 0.0875820365136218 SLC2A1/KMO/EGFR/AKR1B1/CLN3/PDPK1/DDX3X/MAP7/ERRFI1 9 GO:0045445 myoblast differentiation 9/770 84/18722 0.00754017532898731 0.0875820365136218 TBX3/MBNL3/SDC1/DDIT3/EPAS1/BTG1/PPARD/AKIRIN1/SRA1 9 GO:0001889 liver development 13/770 147/18722 0.00770564753526985 0.0892959108563946 ANXA1/ARID5B/HMOX1/EGFR/CEBPB/HES1/GLI3/KRT18/CEBPA/SRSF5/ACO2/LSR/TGFBR3 13 GO:1901989 positive regulation of cell cycle phase transition 11/770 115/18722 0.0077854670982276 0.0900115604419214 ANXA1/EGFR/RAB11A/APP/MDM2/DDX3X/PPP1R10/VPS4B/BRD4/PBX1/CCND3 11 GO:0019079 viral genome replication 12/770 131/18722 0.00782317673607274 0.0902381705459502 BCL2/KPNA6/VCP/EEA1/TBC1D20/DDB1/DDX3X/PPIB/RAB5A/STOM/STAU1/HSPA8 12 GO:0001933 negative regulation of protein phosphorylation 24/770 342/18722 0.00788902323838853 0.0907875353276907 PRKCZ/HSPB1/CDKN1C/PDCD4/UBE2B/MLLT1/HEXIM1/FBLN1/SPAG9/PLPP3/SOCS1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/GSKIP/AKT1S1/LRP1/TSG101/SNX6/ERRFI1/DNAJA1 24 GO:1904292 regulation of ERAD pathway 4/770 20/18722 0.0081244855594897 0.0932477547022817 HERPUD1/UBQLN1/UBXN1/NFE2L2 4 GO:0051384 response to glucocorticoid 13/770 148/18722 0.00814023144601496 0.0932477547022817 ANXA1/HSD11B2/EGFR/SDC1/BCL2/FBXO32/GHR/CDO1/SERPINF1/ERRFI1/USP8/ADM/HSPD1 13 GO:0048588 developmental cell growth 18/770 234/18722 0.00824372235125626 0.0942166708172246 PRKCZ/SEMA6A/EIF4G2/RAB11A/NEDD4L/GOLGA4/APP/SPAG9/SEMA7A/DIP2B/RAB21/CTNNB1/LRP1/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5 18 GO:0007569 cell aging 12/770 132/18722 0.00829399562141711 0.0945743253581727 TBX3/PDCD4/ARG2/SERPINE1/BCL2/MME/ID2/LMNA/CDK2/CALR/MIF/SOD1 12 GO:0000281 mitotic cytokinesis 8/770 71/18722 0.00854429622382705 0.0966117088956478 RASA1/SNX9/CHMP2B/ARF1/VPS4B/CHMP4B/USP8/CHMP2A 8 GO:0150116 regulation of cell-substrate junction organization 8/770 71/18722 0.00854429622382705 0.0966117088956478 FMN1/PHLDB2/DUSP3/LRP1/SLK/SLC9A1/NRP1/FERMT2 8 GO:0010883 regulation of lipid storage 7/770 57/18722 0.00856961174631273 0.0966117088956478 ABHD5/NFKBIA/MEST/ABCG1/PLIN2/PPARD/PNPLA2 7 GO:0061005 cell differentiation involved in kidney development 7/770 57/18722 0.00856961174631273 0.0966117088956478 GATA3/BASP1/HES1/LGR4/GLI3/MTSS1/CTNNB1 7 GO:1900024 regulation of substrate adhesion-dependent cell spreading 7/770 57/18722 0.00856961174631273 0.0966117088956478 FBLN1/P4HB/CALR/KANK1/NRP1/ACTN4/FERMT2 7 GO:1905039 carboxylic acid transmembrane transport 13/770 149/18722 0.00859388632870452 0.0966666717289721 SLC2A1/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SLC19A1/SLC7A5/SLC5A6/CLN8/SLC7A6/IRS2/SLC16A3/SLC13A3 13 GO:0043112 receptor metabolic process 14/770 166/18722 0.00872810102217084 0.0975363521948542 TFRC/MYLIP/EZR/CD63/LRPAP1/EHD3/OPHN1/FURIN/UVRAG/ARF1/LRP1/RAB5A/ADM/AP2M1 14 GO:0010595 positive regulation of endothelial cell migration 12/770 133/18722 0.00878667354386577 0.0975363521948542 ANXA1/HSPB1/HMOX1/PIK3C2A/GATA3/PLPP3/GATA2/PDPK1/CALR/NRP1/PDCD6/NFE2L2 12 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 6/770 44/18722 0.0088358020856115 0.0975363521948542 AKR1B1/HES1/GHR/SOCS1/IL10RB/PRLR 6 GO:0060711 labyrinthine layer development 6/770 44/18722 0.0088358020856115 0.0975363521948542 SPINT1/HES1/GCM1/SPINT2/DNAJB6/ADM 6 GO:0042445 hormone metabolic process 17/770 218/18722 0.0088460815796866 0.0975363521948542 CGA/CYP19A1/HSD17B1/CYP11A1/FDX1/GATA3/BACE2/CTSL/AKR1B1/RDH13/MME/GHR/FURIN/PNPLA2/RDH10/ENPEP/ADM 17 GO:0001731 formation of translation preinitiation complex 3/770 11/18722 0.00892566257291862 0.0975363521948542 EIF5/EIF2S2/EIF4H 3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 3/770 11/18722 0.00892566257291862 0.0975363521948542 HMOX1/EPAS1/NFE2L2 3 GO:0051657 maintenance of organelle location 3/770 11/18722 0.00892566257291862 0.0975363521948542 AKAP9/UVRAG/PAFAH1B1 3 GO:0072697 protein localization to cell cortex 3/770 11/18722 0.00892566257291862 0.0975363521948542 EZR/GNAI1/NUMA1 3 GO:0090084 negative regulation of inclusion body assembly 3/770 11/18722 0.00892566257291862 0.0975363521948542 HSPA1B/DNAJB1/DNAJB6 3 GO:0097494 regulation of vesicle size 3/770 11/18722 0.00892566257291862 0.0975363521948542 RAB11A/RAB5A/AP2M1 3 GO:0099022 vesicle tethering 3/770 11/18722 0.00892566257291862 0.0975363521948542 TRIP11/TBC1D23/EXOC6B 3 GO:1905522 negative regulation of macrophage migration 3/770 11/18722 0.00892566257291862 0.0975363521948542 CD200/DDT/MIF 3 GO:0061008 hepaticobiliary system development 13/770 150/18722 0.00906716772773304 0.0986499929853575 ANXA1/ARID5B/HMOX1/EGFR/CEBPB/HES1/GLI3/KRT18/CEBPA/SRSF5/ACO2/LSR/TGFBR3 13 GO:1903825 organic acid transmembrane transport 13/770 150/18722 0.00906716772773304 0.0986499929853575 SLC2A1/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SLC19A1/SLC7A5/SLC5A6/CLN8/SLC7A6/IRS2/SLC16A3/SLC13A3 13 GO:1902749 regulation of cell cycle G2/M phase transition 10/770 102/18722 0.0092320928900132 0.100054269871855 NABP1/RAB11A/APP/FOXO4/CDK2/VPS4B/BRD4/PBX1/USP47/TAOK1 10 GO:0034764 positive regulation of transmembrane transport 17/770 219/18722 0.009236396576571 0.100054269871855 TCAF1/KCNN4/BRAF/EHD3/AKAP9/P2RY6/OPN3/PDPK1/ARF1/IRS2/SLC9A1/GPC3/AZIN1/SORBS1/COX17/ACTN4/NFE2L2 17 GO:0003338 metanephros morphogenesis 5/770 32/18722 0.0092991226737937 0.100081054608022 BASP1/HES1/LGR4/FMN1/CTNNB1 5 GO:0010039 response to iron ion 5/770 32/18722 0.0092991226737937 0.100081054608022 HMOX1/TFAP2A/BCL2/MAP1LC3A/MDM2 5 GO:0072337 modified amino acid transport 5/770 32/18722 0.0092991226737937 0.100081054608022 SLC19A2/SLC6A8/SLC19A1/SLC5A6/SLC13A3 5 GO:0033673 negative regulation of kinase activity 18/770 237/18722 0.00933934751236127 0.10014461312207 HSPB1/CDKN1C/PDCD4/MLLT1/HEXIM1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/IRS2/GSKIP/AKT1S1/TSG101/SNX6/ERRFI1/DNAJA1 18 GO:0070482 response to oxygen levels 24/770 347/18722 0.009345222777797 0.10014461312207 PGF/HMOX1/PMAIP1/SLC2A1/HSD11B2/BCL2/EPAS1/ATP6V1G1/CPEB4/ATP6V0D1/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/SLC2A8/BNIP2/TGFBR3/ADM/NFE2L2/HSPD1 24 GO:0045604 regulation of epidermal cell differentiation 7/770 58/18722 0.00940937785536138 0.100259365889249 MAFF/NCOA3/HES1/GRHL1/MAFG/NUMA1/ERRFI1 7 GO:2000649 regulation of sodium ion transmembrane transporter activity 7/770 58/18722 0.00940937785536138 0.100259365889249 FXYD3/NEDD4L/KLHL24/SLC9A1/UTRN/STOM/ACTN4 7 GO:0150104 transport across blood-brain barrier 9/770 87/18722 0.00942919216140301 0.100259365889249 TFRC/SLC2A1/SLC38A1/SLC19A1/SLC7A5/SLC5A6/LRP1/SLC13A3/SLC44A1 9 GO:0017157 regulation of exocytosis 16/770 202/18722 0.00945653260444451 0.100259365889249 ANXA1/HMOX1/RAB9A/SDC1/RAP1B/GATA2/SYT7/PDPK1/RAB21/ARF1/VPS4B/TSG101/RAB5A/RAB7A/STXBP3/CHMP2A 16 GO:0032388 positive regulation of intracellular transport 16/770 202/18722 0.00945653260444451 0.100259365889249 DAB2/TCAF1/EZR/GLI3/JUP/LEPROT/UBR5/TBC1D20/EDEM1/SAR1A/MDM2/RAB21/ARF1/NUMA1/SAR1B/STOM 16 GO:0044409 entry into host 13/770 151/18722 0.0095606354610491 0.100933573098321 TFRC/EGFR/SLC52A1/SLC3A2/CD55/CTSL/P4HB/CD46/UVRAG/BSG/LDLR/HSPA1B/NRP1 13 GO:0071456 cellular response to hypoxia 13/770 151/18722 0.0095606354610491 0.100933573098321 HMOX1/PMAIP1/BCL2/EPAS1/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/NFE2L2 13 GO:0045056 transcytosis 4/770 21/18722 0.00971516162945109 0.101703047057888 RAB11A/LRPAP1/LRP1/RAB5A 4 GO:0099515 actin filament-based transport 4/770 21/18722 0.00971516162945109 0.101703047057888 WASL/SYNE2/MYO6/ACTN4 4 GO:0150105 protein localization to cell-cell junction 4/770 21/18722 0.00971516162945109 0.101703047057888 DSP/DLG5/LSR/MPP7 4 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 4/770 21/18722 0.00971516162945109 0.101703047057888 PTTG1IP/BCL2/MDM2/MIF 4 GO:0048538 thymus development 6/770 45/18722 0.00984945891908364 0.102892775249044 GATA3/HES1/BCL2/CTNNB1/PBX1/SOD1 6 GO:0060541 respiratory system development 16/770 203/18722 0.00988792418758656 0.10307850675051 EGFR/BASP1/MAN1A2/HOPX/HES1/EPAS1/GLI3/MME/STK40/CEBPA/DLG5/CTNNB1/DLX5/RDH10/GPC3/ERRFI1 16 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 8/770 73/18722 0.0100532528600518 0.104017317562753 EGFR/IFI6/MVP/DUSP3/TSG101/SNX6/RAB7A/ERRFI1 8 GO:0099518 vesicle cytoskeletal trafficking 8/770 73/18722 0.0100532528600518 0.104017317562753 PRKCZ/WASL/CLN3/RAB1A/MYO6/CCDC186/PAFAH1B1/ACTN4 8 GO:0008406 gonad development 17/770 221/18722 0.0100582341252904 0.104017317562753 CGA/CYP19A1/ARID5B/NUPR1/CEBPB/GATA3/BASP1/SDC1/BCL2/HSPA5/TBC1D20/EIF2S2/ADGRG1/RDH10/EIF2B2/RHOBTB3/SOD1 17 GO:1902115 regulation of organelle assembly 15/770 186/18722 0.0100614784397445 0.104017317562753 NUPR1/EZR/SDC1/CCSAP/LIMK2/CHMP2B/NUMA1/FEZ2/VPS4B/HSPA1B/TSG101/RAB5A/CHMP4B/CDKL5/CHMP2A 15 GO:0010232 vascular transport 9/770 88/18722 0.0101321165932297 0.104350216915958 TFRC/SLC2A1/SLC38A1/SLC19A1/SLC7A5/SLC5A6/LRP1/SLC13A3/SLC44A1 9 GO:0010975 regulation of neuron projection development 29/770 445/18722 0.0101355619079517 0.104350216915958 SEMA6A/EIF4G2/GATA3/RAB11A/MYLIP/NEDD4L/GOLGA4/SEMA7A/CREB3L2/DHX36/AP2A1/HSPA5/DIP2B/TENM3/MDM2/RAPGEF1/RAB21/ATF1/LRP1/KANK1/MAP3K13/NRP1/CAMSAP2/SERPINF1/CUX1/PAFAH1B1/CDKL5/TMEM106B/NFE2L2 29 GO:0032633 interleukin-4 production 5/770 33/18722 0.0105970893230896 0.108626138737453 PRKCZ/CEBPB/GATA3/DDIT3/SLC7A5 5 GO:0032673 regulation of interleukin-4 production 5/770 33/18722 0.0105970893230896 0.108626138737453 PRKCZ/CEBPB/GATA3/DDIT3/SLC7A5 5 GO:0001503 ossification 27/770 408/18722 0.0106162812693437 0.108626138737453 SLC26A2/EGFR/CEBPB/TFAP2A/CRIM1/BCL2/LGR4/GLI3/SMOC1/PHOSPHO1/SBDS/SEMA7A/MSX2/JUND/DHX36/RRBP1/CEBPA/TPM4/TUFT1/CTNNB1/DLX5/GPC3/SUCO/PBX1/ALYREF/HSPE1/FERMT2 27 GO:0046323 glucose import 8/770 74/18722 0.0108778837625183 0.11105448510168 SLC2A1/OPN3/IRS2/RAB4B/STXBP3/GPC3/SORBS1/NFE2L2 8 GO:0001819 positive regulation of cytokine production 30/770 467/18722 0.0108981824633196 0.11105448510168 ANXA1/PRKCZ/HSPB1/HMOX1/CEBPB/GATA3/CD55/APP/SERPINE1/PNP/DDIT3/KPNA6/SLC7A5/SEMA7A/CD200/CD274/DHX36/FURIN/RAB1A/CD46/DDX3X/DDT/AKIRIN2/HSPA1B/LRP1/TBK1/MIF/HSP90AA1/SOD1/HSPD1 30 GO:0010828 positive regulation of glucose transmembrane transport 6/770 46/18722 0.0109431752126658 0.11128539200962 BRAF/OPN3/IRS2/GPC3/SORBS1/NFE2L2 6 GO:0030879 mammary gland development 12/770 137/18722 0.0109892688541935 0.111526530958139 TBX3/CEBPB/GATA3/ZNF703/GLI3/ELF3/ID2/IRF6/IRS2/KDM5B/PRLR/CDO1 12 GO:0030856 regulation of epithelial cell differentiation 13/770 154/18722 0.0111678103293287 0.113108127786677 TBX3/MAFF/CEBPB/GATA3/NCOA3/SERPINE1/HES1/GRHL1/MAFG/BTG1/NUMA1/CTNNB1/ERRFI1 13 GO:1904019 epithelial cell apoptotic process 11/770 121/18722 0.0112160035326932 0.113365812582982 NUPR1/HMOX1/PDCD4/GATA3/SERPINE1/KRT18/GATA2/KRT8/PDPK1/NFE2L2/CAST 11 GO:0061951 establishment of protein localization to plasma membrane 7/770 60/18722 0.011266935501222 0.113650080167185 RAB11A/GOLGA4/KRT18/GRIP1/CLN3/RAB7A/GORASP2 7 GO:0002320 lymphoid progenitor cell differentiation 4/770 22/18722 0.011494936571997 0.113657448565375 GATA3/HES1/BCL2/FNIP1 4 GO:0032727 positive regulation of interferon-alpha production 4/770 22/18722 0.011494936571997 0.113657448565375 DHX36/DDX3X/TBK1/HSPD1 4 GO:2000114 regulation of establishment of cell polarity 4/770 22/18722 0.011494936571997 0.113657448565375 GATA3/RAP1B/RICTOR/KANK1 4 GO:0034333 adherens junction assembly 3/770 12/18722 0.0115413744680072 0.113657448565375 ZNF703/DLG5/CTNNB1 3 GO:0035739 CD4-positive, alpha-beta T cell proliferation 3/770 12/18722 0.0115413744680072 0.113657448565375 CD55/ARG2/CD274 3 GO:0038203 TORC2 signaling 3/770 12/18722 0.0115413744680072 0.113657448565375 SIK3/SYAP1/RICTOR 3 GO:0043248 proteasome assembly 3/770 12/18722 0.0115413744680072 0.113657448565375 PSMD11/ADRM1/POMP 3 GO:0045916 negative regulation of complement activation 3/770 12/18722 0.0115413744680072 0.113657448565375 CD55/CD46/CD59 3 GO:0060019 radial glial cell differentiation 3/770 12/18722 0.0115413744680072 0.113657448565375 HES1/GLI3/GPR157 3 GO:0090085 regulation of protein deubiquitination 3/770 12/18722 0.0115413744680072 0.113657448565375 VCP/TANK/UBXN1 3 GO:2000009 negative regulation of protein localization to cell surface 3/770 12/18722 0.0115413744680072 0.113657448565375 NEDD4L/LEPROT/COMMD1 3 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 3/770 12/18722 0.0115413744680072 0.113657448565375 CD55/ARG2/CD274 3 GO:0055076 transition metal ion homeostasis 12/770 138/18722 0.0116012443445746 0.114021697374783 SLC40A1/TFRC/HMOX1/APP/EPAS1/ATP6V1G1/EIF2AK1/SLC39A7/ATP6V0D1/ARF1/COMMD1/SOD1 12 GO:0008088 axo-dendritic transport 8/770 75/18722 0.0117514533148468 0.115270653283231 HSPB1/APP/ARL8B/RAB21/ARMCX3/PAFAH1B1/HSPA8/SOD1 8 GO:0016358 dendrite development 18/770 243/18722 0.0118794079984854 0.116296837046076 EIF4G2/NEDD4L/APP/C21orf91/DHX36/WASL/ARF4/GRIP1/DLG5/LAMC2/RAB21/ARF1/NRP1/CAMSAP2/CUX1/PAFAH1B1/CDKL5/TMEM106B 18 GO:0002183 cytoplasmic translational initiation 5/770 34/18722 0.0120136277060317 0.116466744862172 EIF5/EIF2S2/EIF4H/EIF4A1/EIF3J 5 GO:0009649 entrainment of circadian clock 5/770 34/18722 0.0120136277060317 0.116466744862172 ID2/BHLHE40/NR2F6/PHLPP1/PPP1CB 5 GO:0032212 positive regulation of telomere maintenance via telomerase 5/770 34/18722 0.0120136277060317 0.116466744862172 NEK7/PKIB/TNKS2/CTNNB1/MAP3K4 5 GO:0051973 positive regulation of telomerase activity 5/770 34/18722 0.0120136277060317 0.116466744862172 NEK7/PKIB/CTNNB1/MAP3K4/HSP90AA1 5 GO:2000352 negative regulation of endothelial cell apoptotic process 5/770 34/18722 0.0120136277060317 0.116466744862172 GATA3/SERPINE1/GATA2/PDPK1/NFE2L2 5 GO:0014911 positive regulation of smooth muscle cell migration 6/770 47/18722 0.0121200733413841 0.116591361892118 BCL2/P2RY6/FOXO4/MDM2/LRP1/NRP1 6 GO:0032008 positive regulation of TOR signaling 6/770 47/18722 0.0121200733413841 0.116591361892118 SLC38A9/RRAGC/SIK3/FNIP1/RICTOR/RHEB 6 GO:0046677 response to antibiotic 6/770 47/18722 0.0121200733413841 0.116591361892118 HSPA5/MDM2/KDM5B/SLC9A1/HSP90AA1/SOD1 6 GO:0051489 regulation of filopodium assembly 6/770 47/18722 0.0121200733413841 0.116591361892118 MYO10/WASL/CLN3/MIEN1/RAB5A/NRP1 6 GO:0060998 regulation of dendritic spine development 7/770 61/18722 0.0122891248487125 0.117762902156028 EIF4G2/C21orf91/DHX36/DLG5/ARF1/PAFAH1B1/CDKL5 7 GO:1904356 regulation of telomere maintenance via telomere lengthening 7/770 61/18722 0.0122891248487125 0.117762902156028 NEK7/DHX36/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4 7 GO:0071241 cellular response to inorganic substance 17/770 226/18722 0.012368540811989 0.118296427766106 HSD17B1/HMOX1/EGFR/TFAP2A/APP/BRAF/MAP1LC3A/JUND/HSPA5/CEBPA/SYT7/CDK2/CALR/EIF4A3/SERPINF1/SOD1/NFE2L2 17 GO:0060191 regulation of lipase activity 9/770 91/18722 0.012478184463083 0.119116462029775 ANXA1/PRKCZ/EGFR/ABHD5/ARF4/P2RY6/FURIN/PDPK1/LRP1 9 GO:0031100 animal organ regeneration 8/770 76/18722 0.0126755763864138 0.12053892582729 PGF/HMOX1/EGFR/CEBPB/GLI3/SRSF5/TGFBR3/ADM 8 GO:0043536 positive regulation of blood vessel endothelial cell migration 8/770 76/18722 0.0126755763864138 0.12053892582729 ANXA1/HSPB1/HMOX1/PIK3C2A/GATA2/PDPK1/NRP1/NFE2L2 8 GO:0045137 development of primary sexual characteristics 17/770 227/18722 0.0128771056773471 0.122222128743277 CGA/CYP19A1/ARID5B/NUPR1/CEBPB/GATA3/BASP1/SDC1/BCL2/HSPA5/TBC1D20/EIF2S2/ADGRG1/RDH10/EIF2B2/RHOBTB3/SOD1 17 GO:0001837 epithelial to mesenchymal transition 13/770 157/18722 0.0129771384638847 0.122704138454531 TBX3/DAB2/PDCD4/GATA3/ZNF703/BCL9L/PHLDB2/ZNF750/DLG5/CTNNB1/PDCD6/TGFBR3/FERMT2 13 GO:0002262 myeloid cell homeostasis 13/770 157/18722 0.0129771384638847 0.122704138454531 ANXA1/HMOX1/GATA3/ALAS1/EPAS1/BPGM/GATA2/ID2/SLC25A5/HSPA1B/TGFBR3/UBA5/SOD1 13 GO:0032970 regulation of actin filament-based process 26/770 396/18722 0.0131749463544703 0.124338556220314 RHOBTB1/RASA1/SCIN/DSP/MTSS1/SPIRE2/AKAP9/FMN1/WASL/JUP/PHLDB2/JMY/PPFIA1/CDC42EP4/SNX9/ARF1/RICTOR/LRP1/KANK1/SLC9A1/NRP1/ARHGAP18/RHOBTB3/TAOK1/FERMT2/IQGAP2 26 GO:0007623 circadian rhythm 16/770 210/18722 0.0133613454135396 0.125354289760245 EGFR/TOP1/SIAH2/LGR4/JUND/ID2/NFIL3/OPN3/BHLHE40/GPR157/NR2F6/DDB1/CSNK1E/PHLPP1/CLDN4/PPP1CB 16 GO:0015804 neutral amino acid transport 6/770 48/18722 0.0133831993081377 0.125354289760245 SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5 6 GO:0042149 cellular response to glucose starvation 6/770 48/18722 0.0133831993081377 0.125354289760245 PMAIP1/SLC2A1/BCL2/CPEB4/HSPA5/NFE2L2 6 GO:0120009 intermembrane lipid transfer 6/770 48/18722 0.0133831993081377 0.125354289760245 GRAMD1C/PITPNA/ABCG1/GLTP/PRELID1/OSBP 6 GO:1900273 positive regulation of long-term synaptic potentiation 4/770 23/18722 0.013471313279094 0.125531956723545 SQSTM1/APP/MME/STAU1 4 GO:0033138 positive regulation of peptidyl-serine phosphorylation 10/770 108/18722 0.0135005309589586 0.125531956723545 TFRC/EGFR/APP/BCL2/BRAF/AKAP9/FNIP1/TBK1/MIF/HSP90AA1 10 GO:0010765 positive regulation of sodium ion transport 5/770 35/18722 0.0135533198308784 0.125531956723545 PRSS8/MLLT6/ARF1/SLC9A1/ACTN4 5 GO:0070536 protein K63-linked deubiquitination 5/770 35/18722 0.0135533198308784 0.125531956723545 OTUB2/VCP/USP8/USP16/PSMD14 5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 5/770 35/18722 0.0135533198308784 0.125531956723545 ANXA1/HMOX1/PIK3C2A/GATA2/NRP1 5 GO:0097421 liver regeneration 5/770 35/18722 0.0135533198308784 0.125531956723545 HMOX1/EGFR/CEBPB/GLI3/SRSF5 5 GO:0032418 lysosome localization 8/770 77/18722 0.0136518539210949 0.126209996454204 HMOX1/SPAG9/ARL8B/GATA2/PDPK1/PLEKHM2/SNAP23/TMEM106B 8 GO:0001649 osteoblast differentiation 17/770 229/18722 0.013943441300397 0.128666977777552 CEBPB/CRIM1/LGR4/GLI3/SMOC1/SEMA7A/MSX2/JUND/RRBP1/CEBPA/TPM4/CTNNB1/DLX5/SUCO/ALYREF/HSPE1/FERMT2 17 GO:0050673 epithelial cell proliferation 28/770 437/18722 0.014018712590662 0.129122448871106 PGF/NUPR1/CDKN1C/HMOX1/EGFR/CEBPB/GATA3/ZNF703/HES1/LGR4/MTSS1/ERN1/GATA2/ID2/PPARD/IRF6/PDPK1/KDM5B/CTNNB1/DLX5/RICTOR/NRP1/GPC3/SERPINF1/PDCD6/ERRFI1/TGFBR3/MYDGF 28 GO:0050878 regulation of body fluid levels 25/770 379/18722 0.0140934869676581 0.129571670774613 HSPB1/ST3GAL4/HSD11B2/SERPINB2/EGFR/VAV3/FBLN1/AKR1B1/KCNN4/SERPINE1/GNA12/AK3/GRHL1/GNAS/F5/MLLT6/C1QTNF1/PRLR/CDO1/CD59/STXBP3/LSR/ADM/CLDN4/NFE2L2 25 GO:0036293 response to decreased oxygen levels 22/770 322/18722 0.0141850095794353 0.130172933212387 PGF/HMOX1/PMAIP1/SLC2A1/HSD11B2/BCL2/EPAS1/CPEB4/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/SLC2A8/BNIP2/TGFBR3/ADM/NFE2L2/HSPD1 22 GO:0060349 bone morphogenesis 9/770 93/18722 0.0142524453624356 0.130551351545986 TFAP2A/ANXA6/GLI3/PHOSPHO1/GHR/MSX2/TRIP11/DLX5/INSIG1 9 GO:0072006 nephron development 12/770 142/18722 0.014314767484666 0.13064935933941 GATA3/BASP1/HES1/BCL2/LGR4/GLI3/MTSS1/FMN1/CTNNB1/ENPEP/GPC3/PBX1 12 GO:0032352 positive regulation of hormone metabolic process 3/770 13/18722 0.0145515541708554 0.13064935933941 GATA3/RDH10/ADM 3 GO:0032429 regulation of phospholipase A2 activity 3/770 13/18722 0.0145515541708554 0.13064935933941 ANXA1/EGFR/LRP1 3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 3/770 13/18722 0.0145515541708554 0.13064935933941 CTNNB1/SUPT6H/BRD4 3 GO:0070234 positive regulation of T cell apoptotic process 3/770 13/18722 0.0145515541708554 0.13064935933941 LGALS16/CD274/PRELID1 3 GO:0071696 ectodermal placode development 3/770 13/18722 0.0145515541708554 0.13064935933941 TBX3/CTNNB1/NRP1 3 GO:0090161 Golgi ribbon formation 3/770 13/18722 0.0145515541708554 0.13064935933941 FHDC1/GOLGA2/TRIP11 3 GO:1900044 regulation of protein K63-linked ubiquitination 3/770 13/18722 0.0145515541708554 0.13064935933941 OTUB2/UBR5/DDX3X 3 GO:1900115 extracellular regulation of signal transduction 3/770 13/18722 0.0145515541708554 0.13064935933941 GREM2/LRPAP1/CD46 3 GO:1900116 extracellular negative regulation of signal transduction 3/770 13/18722 0.0145515541708554 0.13064935933941 GREM2/LRPAP1/CD46 3 GO:1903651 positive regulation of cytoplasmic transport 3/770 13/18722 0.0145515541708554 0.13064935933941 DAB2/EZR/RAB21 3 GO:0009409 response to cold 6/770 49/18722 0.0147355137200409 0.131354319976679 NFKBIA/ACADVL/SLC9A1/HSP90AA1/ADM/HSPD1 6 GO:0034332 adherens junction organization 6/770 49/18722 0.0147355137200409 0.131354319976679 ZNF703/DSP/MTSS1/DLG5/CTNNB1/FERMT2 6 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/770 49/18722 0.0147355137200409 0.131354319976679 HMOX1/PMAIP1/ATF3/SERPINE1/DDX3X/TMBIM1 6 GO:1904894 positive regulation of receptor signaling pathway via STAT 6/770 49/18722 0.0147355137200409 0.131354319976679 AKR1B1/HES1/GHR/SOCS1/IL10RB/PRLR 6 GO:0030324 lung development 14/770 177/18722 0.014762611745956 0.131360882732319 EGFR/MAN1A2/HOPX/HES1/EPAS1/GLI3/MME/STK40/CEBPA/DLG5/CTNNB1/RDH10/GPC3/ERRFI1 14 GO:0030010 establishment of cell polarity 12/770 143/18722 0.0150629523997969 0.133556391117772 PRKCZ/GATA3/HES1/SNX27/RAP1B/OPHN1/NUMA1/RICTOR/KANK1/HSP90AA1/PAFAH1B1/MPP7 12 GO:0062013 positive regulation of small molecule metabolic process 12/770 143/18722 0.0150629523997969 0.133556391117772 ANXA1/PMAIP1/APP/VCP/P2RY6/ABCG1/PPARD/DDB1/IRS2/RDH10/SORBS1/ADM 12 GO:1902414 protein localization to cell junction 9/770 94/18722 0.0152063481756318 0.134474892399698 PRKCZ/HSPB1/RAB11A/DSP/GRIP1/DLG5/LSR/MPP7/FERMT2 9 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 5/770 36/18722 0.0152205176226028 0.134474892399698 ABCG1/PPARD/DYNLL1/LRP1/OSBP 5 GO:0060562 epithelial tube morphogenesis 22/770 325/18722 0.0156301015769762 0.137546974368919 TBX3/GATA3/SPINT1/HES1/BCL2/LGR4/GLI3/MTSS1/HECTD1/FMN1/MIB1/DVL3/DLG5/SPINT2/BRD2/KDM5B/CTNNB1/RDH10/NRP1/GPC3/PBX1/ADM 22 GO:0021801 cerebral cortex radial glia-guided migration 4/770 24/18722 0.0156510404309004 0.137546974368919 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0022030 telencephalon glial cell migration 4/770 24/18722 0.0156510404309004 0.137546974368919 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0032507 maintenance of protein location in cell 7/770 64/18722 0.0157550731508892 0.137838421165606 SCIN/HSPA5/RER1/KDELR2/SKP1/KDELR1/INSIG1 7 GO:1903018 regulation of glycoprotein metabolic process 7/770 64/18722 0.0157550731508892 0.137838421165606 BACE2/BCL2/GOLGA2/RAB1A/CTNNB1/AGO2/TMEM59 7 GO:1901184 regulation of ERBB signaling pathway 8/770 79/18722 0.0157671884536214 0.137838421165606 EGFR/IFI6/MVP/DUSP3/TSG101/SNX6/RAB7A/ERRFI1 8 GO:0006644 phospholipid metabolic process 25/770 383/18722 0.0158648115821753 0.138448959919404 PIK3C2A/MTMR10/SERINC5/PLPP3/ABHD5/SAMD8/ABHD3/SOCS1/ISYNA1/CLN3/TTC7B/SH3YL1/PNPLA8/PPARD/CLN8/ARF1/IDI1/LDLR/PI4K2A/SYNJ1/PRDX6/PAFAH1B1/PTDSS1/SLC44A1/TMEM150A 25 GO:0051235 maintenance of location 22/770 326/18722 0.0161368238900032 0.140460554448559 SCIN/DDIT3/ANXA6/ABHD5/NFKBIA/AKAP9/P2RY6/HSPA5/MEST/RER1/ABCG1/KDELR2/PLIN2/PPARD/SKP1/PDPK1/UVRAG/CALR/PNPLA2/KDELR1/INSIG1/PAFAH1B1 22 GO:0007080 mitotic metaphase plate congression 6/770 50/18722 0.0161798832537574 0.140460554448559 RAB11A/CHMP2B/VPS4B/CHMP4B/EML4/CHMP2A 6 GO:0070231 T cell apoptotic process 6/770 50/18722 0.0161798832537574 0.140460554448559 LGALS16/ARG2/GLI3/CD274/PRELID1/KDELR1 6 GO:0042692 muscle cell differentiation 25/770 384/18722 0.0163341793480503 0.141373863513186 ERVFRD-1/GDF15/TBX3/ERVW-1/PDCD4/HOPX/SPAG9/SDC1/HES1/BCL2/HDAC5/DYSF/KRT8/ID2/FOXO4/NEBL/MDM2/LMNA/CTNNB1/SUPT6H/CALR/SLC9A1/ADM/ACTN4/MYOF 25 GO:0071248 cellular response to metal ion 15/770 197/18722 0.0163418313031497 0.141373863513186 HSD17B1/HMOX1/EGFR/TFAP2A/APP/BRAF/MAP1LC3A/JUND/HSPA5/CEBPA/SYT7/CALR/SERPINF1/SOD1/NFE2L2 15 GO:0031669 cellular response to nutrient levels 16/770 215/18722 0.0163777698320628 0.141439215031488 HMOX1/PMAIP1/SLC2A1/MAP1LC3B/GABARAPL1/ATF3/BCL2/CPEB4/MAP1LC3A/RRAGC/HSPA5/MDM2/FNIP1/GABARAPL2/HSPA8/NFE2L2 16 GO:0006909 phagocytosis 21/770 308/18722 0.0166442912675237 0.143492220391125 ANXA1/RHOBTB1/VAV3/GULP1/TGM2/ARL8B/EIF2AK1/DYSF/GATA2/P2RY6/CLCN3/SYT7/CLN3/LMAN2/LDLR/LRP1/CALR/RAB5A/COLEC12/RAB7A/SOD1 21 GO:0015698 inorganic anion transport 14/770 180/18722 0.0168649208656622 0.145024603738371 SLC26A2/SLC13A4/SLC22A11/FXYD3/CLIC3/CEBPB/GABRE/SLC5A6/P2RY6/CLCN3/SLC4A2/SLC12A4/SLC20A1/CLDN4 14 GO:0032204 regulation of telomere maintenance 8/770 80/18722 0.0169093507469383 0.145024603738371 NEK7/DHX36/PKIB/TNKS2/XRN1/PPP1R10/CTNNB1/MAP3K4 8 GO:0051303 establishment of chromosome localization 8/770 80/18722 0.0169093507469383 0.145024603738371 UBE2B/RAB11A/CHMP2B/NUMA1/VPS4B/CHMP4B/EML4/CHMP2A 8 GO:0050775 positive regulation of dendrite morphogenesis 5/770 37/18722 0.0170193286618129 0.145483449589304 DHX36/RAB21/CUX1/PAFAH1B1/CDKL5 5 GO:0051310 metaphase plate congression 7/770 65/18722 0.0170504384025996 0.145483449589304 RAB11A/CHMP2B/NUMA1/VPS4B/CHMP4B/EML4/CHMP2A 7 GO:1902475 L-alpha-amino acid transmembrane transport 7/770 65/18722 0.0170504384025996 0.145483449589304 SLC43A2/SLC3A2/SLC38A1/SLC38A9/SLC7A5/CLN8/SLC7A6 7 GO:1904035 regulation of epithelial cell apoptotic process 9/770 96/18722 0.0172537800626678 0.146495931168205 NUPR1/HMOX1/PDCD4/GATA3/SERPINE1/GATA2/PDPK1/NFE2L2/CAST 9 GO:0034101 erythrocyte homeostasis 11/770 129/18722 0.0174551753582445 0.146495931168205 HMOX1/GATA3/ALAS1/EPAS1/BPGM/GATA2/ID2/SLC25A5/HSPA1B/TGFBR3/UBA5 11 GO:0030323 respiratory tube development 14/770 181/18722 0.0176141548729406 0.146495931168205 EGFR/MAN1A2/HOPX/HES1/EPAS1/GLI3/MME/STK40/CEBPA/DLG5/CTNNB1/RDH10/GPC3/ERRFI1 14 GO:0045766 positive regulation of angiogenesis 14/770 181/18722 0.0176141548729406 0.146495931168205 PGF/HSPB1/HMOX1/SERPINE1/BTG1/GATA2/JUP/PDPK1/NRP1/AGO2/PDCD6/ADM/MYDGF/NFE2L2 14 GO:1904018 positive regulation of vasculature development 14/770 181/18722 0.0176141548729406 0.146495931168205 PGF/HSPB1/HMOX1/SERPINE1/BTG1/GATA2/JUP/PDPK1/NRP1/AGO2/PDCD6/ADM/MYDGF/NFE2L2 14 GO:0006979 response to oxidative stress 28/770 446/18722 0.0178936963442918 0.146495931168205 ANXA1/HSPB1/HMOX1/EGFR/GPX3/APP/SDC1/BCL2/EPAS1/NDUFA6/MAP1LC3A/OSER1/ERN1/BTG1/P4HB/PNPLA8/CLN8/MDM2/CTNNB1/GSKIP/HSPA1B/UBQLN1/PRDX6/STAU1/PSMB5/SOD1/NFE2L2/HSPD1 28 GO:0006596 polyamine biosynthetic process 3/770 14/18722 0.0179631955052181 0.146495931168205 SAT1/SMS/AZIN1 3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 3/770 14/18722 0.0179631955052181 0.146495931168205 TSG101/SNX6/ERRFI1 3 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 3/770 14/18722 0.0179631955052181 0.146495931168205 FBLN1/KANK1/ACTN4 3 GO:0031468 nuclear membrane reassembly 3/770 14/18722 0.0179631955052181 0.146495931168205 CHMP4B/CHMP2A/UBE2I 3 GO:0042415 norepinephrine metabolic process 3/770 14/18722 0.0179631955052181 0.146495931168205 GATA3/AKR1B1/EPAS1 3 GO:0070141 response to UV-A 3/770 14/18722 0.0179631955052181 0.146495931168205 EGFR/MME/OPN3 3 GO:0071236 cellular response to antibiotic 3/770 14/18722 0.0179631955052181 0.146495931168205 HSPA5/MDM2/SLC9A1 3 GO:0072160 nephron tubule epithelial cell differentiation 3/770 14/18722 0.0179631955052181 0.146495931168205 GATA3/MTSS1/CTNNB1 3 GO:0099638 endosome to plasma membrane protein transport 3/770 14/18722 0.0179631955052181 0.146495931168205 RAB11A/GRIP1/RAB7A 3 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 3/770 14/18722 0.0179631955052181 0.146495931168205 FBLN1/KANK1/ACTN4 3 GO:1903894 regulation of IRE1-mediated unfolded protein response 3/770 14/18722 0.0179631955052181 0.146495931168205 DNAJB9/HSPA5/TMEM33 3 GO:1904294 positive regulation of ERAD pathway 3/770 14/18722 0.0179631955052181 0.146495931168205 HERPUD1/UBQLN1/NFE2L2 3 GO:0032469 endoplasmic reticulum calcium ion homeostasis 4/770 25/18722 0.018040103724832 0.146495931168205 APP/BCL2/TGM2/HERPUD1 4 GO:0032753 positive regulation of interleukin-4 production 4/770 25/18722 0.018040103724832 0.146495931168205 PRKCZ/CEBPB/GATA3/SLC7A5 4 GO:0032878 regulation of establishment or maintenance of cell polarity 4/770 25/18722 0.018040103724832 0.146495931168205 GATA3/RAP1B/RICTOR/KANK1 4 GO:0045324 late endosome to vacuole transport 4/770 25/18722 0.018040103724832 0.146495931168205 LEPROT/CHMP2B/CHMP4B/CHMP2A 4 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 4/770 25/18722 0.018040103724832 0.146495931168205 MED13/DHX36/SUB1/PSMC6 4 GO:0090382 phagosome maturation 4/770 25/18722 0.018040103724832 0.146495931168205 ARL8B/SYT7/CLN3/RAB7A 4 GO:0031623 receptor internalization 10/770 113/18722 0.0180659547142059 0.146495931168205 TFRC/EZR/CD63/LRPAP1/OPHN1/ARF1/LRP1/RAB5A/ADM/AP2M1 10 GO:0044106 cellular amine metabolic process 10/770 113/18722 0.0180659547142059 0.146495931168205 KMO/GATA3/AKR1B1/SAT1/EPAS1/CLN3/SMS/MAOA/AZIN1/SLC44A1 10 GO:0050792 regulation of viral process 13/770 164/18722 0.0180725310860692 0.146495931168205 HEXIM1/BCL2/KPNA6/P4HB/TBC1D20/CHMP2B/DDB1/DDX3X/TSG101/RAB7A/STOM/STAU1/CHMP2A 13 GO:0000422 autophagy of mitochondrion 8/770 81/18722 0.0181098722856942 0.146495931168205 SQSTM1/MAP1LC3B/GABARAPL1/ATG9B/MAP1LC3A/ATG2A/SLC25A5/GABARAPL2 8 GO:0010833 telomere maintenance via telomere lengthening 8/770 81/18722 0.0181098722856942 0.146495931168205 NEK7/DHX36/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4/HSP90AA1 8 GO:0048708 astrocyte differentiation 8/770 81/18722 0.0181098722856942 0.146495931168205 EGFR/BACE2/APP/HES1/GCM1/ID2/LDLR/LRP1 8 GO:0061726 mitochondrion disassembly 8/770 81/18722 0.0181098722856942 0.146495931168205 SQSTM1/MAP1LC3B/GABARAPL1/ATG9B/MAP1LC3A/ATG2A/SLC25A5/GABARAPL2 8 GO:2001021 negative regulation of response to DNA damage stimulus 8/770 81/18722 0.0181098722856942 0.146495931168205 OTUB2/PTTG1IP/BCL2/UBR5/MDM2/PPP1R10/MIF/USP47 8 GO:0046942 carboxylic acid transport 19/770 273/18722 0.0181704416607699 0.14674766741591 SLC26A2/ANXA1/KMO/SLC19A2/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC6A8/SLC19A1/SLC7A5/SLC5A6/CLN3/PNPLA8/CLN8/SLC7A6/SLC16A3/SLC13A3 19 GO:0042476 odontogenesis 11/770 130/18722 0.0183870893540461 0.14825706513141 CSF3R/TFAP2A/SERPINE1/SDC1/GLI3/SP6/SLC4A2/TUFT1/CTNNB1/BSG/ADM 11 GO:0035136 forelimb morphogenesis 5/770 38/18722 0.0189536037186772 0.152578040921112 TBX3/TFAP2A/FMN1/CTNNB1/RDH10 5 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 18/770 256/18722 0.0192494883987691 0.154710001114624 GDF15/DAB2/CDKN1C/GREM2/PEG10/ZNF703/HES1/CRIM1/DACT2/BCL9L/HSPA5/LATS2/PDPK1/NUMA1/LRP1/SNX6/GPC3/TGFBR3 18 GO:0021545 cranial nerve development 6/770 52/18722 0.0193557371039236 0.155179913137648 TFAP2A/HES1/GLI3/ERBB3/CTNNB1/NRP1 6 GO:2001252 positive regulation of chromosome organization 8/770 82/18722 0.0193702400103586 0.155179913137648 NEK7/DHX36/PKIB/TNKS2/NUMA1/PPP1R10/CTNNB1/MAP3K4 8 GO:0006513 protein monoubiquitination 7/770 67/18722 0.0198632039100205 0.15811237233807 UBE2B/NEDD4L/RYBP/SKP1/DDB1/TSG101/PDCD6 7 GO:0010517 regulation of phospholipase activity 7/770 67/18722 0.0198632039100205 0.15811237233807 ANXA1/PRKCZ/EGFR/ARF4/P2RY6/PDPK1/LRP1 7 GO:0061180 mammary gland epithelium development 7/770 67/18722 0.0198632039100205 0.15811237233807 TBX3/CEBPB/GATA3/ZNF703/ID2/IRF6/KDM5B 7 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 7/770 67/18722 0.0198632039100205 0.15811237233807 ANXA1/PRKCZ/GATA3/CD55/ARG2/SOCS1/CD274 7 GO:0045834 positive regulation of lipid metabolic process 12/770 149/18722 0.0201905293684901 0.160461575507474 CGA/ANXA1/VAV3/ABHD5/ABCG1/PPARD/IRS2/LDLR/PNPLA2/RDH10/SORBS1/ADM 12 GO:0006066 alcohol metabolic process 23/770 353/18722 0.020478005666568 0.162374465168494 CYP11A1/FDX1/APP/AKR1B1/RDH13/PLPP3/ACSS1/P2RY6/ISYNA1/CEBPA/ABCG1/HDLBP/PPARD/CLN8/ACADVL/IDI1/LDLR/SYNJ1/PNPLA2/RDH10/ACO2/INSIG1/SOD1 23 GO:0072273 metanephric nephron morphogenesis 4/770 26/18722 0.0206437235279293 0.162374465168494 HES1/LGR4/FMN1/CTNNB1 4 GO:1902186 regulation of viral release from host cell 4/770 26/18722 0.0206437235279293 0.162374465168494 CHMP2B/DDB1/TSG101/CHMP2A 4 GO:1904353 regulation of telomere capping 4/770 26/18722 0.0206437235279293 0.162374465168494 NEK7/PKIB/TNKS2/MAP3K4 4 GO:0031960 response to corticosteroid 13/770 167/18722 0.0206681670408345 0.162374465168494 ANXA1/HSD11B2/EGFR/SDC1/BCL2/FBXO32/GHR/CDO1/SERPINF1/ERRFI1/USP8/ADM/HSPD1 13 GO:0062012 regulation of small molecule metabolic process 22/770 334/18722 0.0206717668378968 0.162374465168494 ANXA1/NUPR1/PMAIP1/PHLDA2/APP/VCP/P2RY6/ABCG1/CLN3/PPARD/DDB1/IRS2/ACADVL/C1QTNF1/LDLR/RDH10/INSIG1/SORBS1/SLC35B4/ADM/SOD1/PPP1CB 22 GO:0060996 dendritic spine development 9/770 99/18722 0.020691820157689 0.162374465168494 EIF4G2/C21orf91/DHX36/WASL/ARF4/DLG5/ARF1/PAFAH1B1/CDKL5 9 GO:0050886 endocrine process 8/770 83/18722 0.0206919095689331 0.162374465168494 CGA/TBX3/HSD11B2/GATA3/MME/C1QTNF1/ENPEP/RAB11FIP1 8 GO:0110053 regulation of actin filament organization 19/770 277/18722 0.0208016656042371 0.162816190841294 RASA1/SCIN/MTSS1/SPIRE2/FMN1/WASL/PHLDB2/JMY/PPFIA1/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/SLC9A1/NRP1/ARHGAP18/FERMT2/IQGAP2 19 GO:0010038 response to metal ion 24/770 373/18722 0.0208135487790296 0.162816190841294 HSD17B1/HMOX1/EGFR/TFAP2A/NEDD4L/APP/SDC1/BCL2/BRAF/MAP1LC3A/GGH/JUND/HSPA5/CEBPA/SYT7/MDM2/ATF1/BSG/CALR/SERPINF1/PDCD6/SEC31A/SOD1/NFE2L2 24 GO:0046326 positive regulation of glucose import 5/770 39/18722 0.0210269260332562 0.163944158809162 OPN3/IRS2/GPC3/SORBS1/NFE2L2 5 GO:0071548 response to dexamethasone 5/770 39/18722 0.0210269260332562 0.163944158809162 EGFR/FBXO32/SERPINF1/ERRFI1/USP8 5 GO:0032210 regulation of telomere maintenance via telomerase 6/770 53/18722 0.021092415507959 0.163944158809162 NEK7/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4 6 GO:1990090 cellular response to nerve growth factor stimulus 6/770 53/18722 0.021092415507959 0.163944158809162 APP/HSPA5/PDPK1/RAPGEF1/EIF4A3/USP8 6 GO:0010812 negative regulation of cell-substrate adhesion 7/770 68/18722 0.0213843997433847 0.163944158809162 RASA1/FBLN1/SERPINE1/PHLDB2/LRP1/KANK1/ACTN4 7 GO:0071383 cellular response to steroid hormone stimulus 15/770 204/18722 0.0216827799029719 0.163944158809162 ANXA1/DAB2/ESRRG/EGFR/PGRMC2/FBXO32/UBR5/PPARD/EGLN2/CALR/SERPINF1/ERRFI1/USP8/DNAJA1/UBA5 15 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 23/770 355/18722 0.0217056998454679 0.163944158809162 GDF15/DAB2/CDKN1C/PDCD4/GREM2/PEG10/ZNF703/HES1/CRIM1/DACT2/BCL9L/HSPA5/FURIN/LATS2/PDPK1/NUMA1/DLX5/LRP1/SNX6/GPC3/TGFBR3/SUB1/FERMT2 23 GO:0120032 regulation of plasma membrane bounded cell projection assembly 14/770 186/18722 0.0217461671974509 0.163944158809162 EPS8L1/MYO10/WASL/ARHGAP24/LIMK2/CLN3/SH3YL1/CDC42EP4/AKIRIN1/MIEN1/RAB5A/KANK1/NRP1/CDKL5 14 GO:0010889 regulation of sequestering of triglyceride 3/770 15/18722 0.0217802595086624 0.163944158809162 ABHD5/PLIN2/PNPLA2 3 GO:0032486 Rap protein signal transduction 3/770 15/18722 0.0217802595086624 0.163944158809162 RAP1B/RAPGEF1/RAP2C 3 GO:0033599 regulation of mammary gland epithelial cell proliferation 3/770 15/18722 0.0217802595086624 0.163944158809162 GATA3/ZNF703/KDM5B 3 GO:0042976 activation of Janus kinase activity 3/770 15/18722 0.0217802595086624 0.163944158809162 GHR/SOCS1/PRLR 3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 3/770 15/18722 0.0217802595086624 0.163944158809162 PTTG1IP/MDM2/MIF 3 GO:0043584 nose development 3/770 15/18722 0.0217802595086624 0.163944158809162 GLI3/DLX5/RDH10 3 GO:0045064 T-helper 2 cell differentiation 3/770 15/18722 0.0217802595086624 0.163944158809162 ANXA1/PRKCZ/GATA3 3 GO:0045176 apical protein localization 3/770 15/18722 0.0217802595086624 0.163944158809162 ARF4/NAPA/DLG5 3 GO:0051127 positive regulation of actin nucleation 3/770 15/18722 0.0217802595086624 0.163944158809162 SCIN/FMN1/WASL 3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 3/770 15/18722 0.0217802595086624 0.163944158809162 EDEM1/SAR1A/SAR1B 3 GO:0071474 cellular hyperosmotic response 3/770 15/18722 0.0217802595086624 0.163944158809162 SLC2A1/AKR1B1/ERRFI1 3 GO:0072044 collecting duct development 3/770 15/18722 0.0217802595086624 0.163944158809162 AKR1B1/DACT2/DLG5 3 GO:0098760 response to interleukin-7 3/770 15/18722 0.0217802595086624 0.163944158809162 P4HB/PDIA3/HSPD1 3 GO:0098761 cellular response to interleukin-7 3/770 15/18722 0.0217802595086624 0.163944158809162 P4HB/PDIA3/HSPD1 3 GO:0150011 regulation of neuron projection arborization 3/770 15/18722 0.0217802595086624 0.163944158809162 GRIP1/DVL3/MAP3K13 3 GO:1902902 negative regulation of autophagosome assembly 3/770 15/18722 0.0217802595086624 0.163944158809162 NUPR1/FEZ2/CHMP4B 3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 3/770 15/18722 0.0217802595086624 0.163944158809162 DAB2/CSNK1E/GPC3 3 GO:0061640 cytoskeleton-dependent cytokinesis 9/770 100/18722 0.0219403044781237 0.164899754471328 RASA1/SPIRE2/SNX9/CHMP2B/ARF1/VPS4B/CHMP4B/USP8/CHMP2A 9 GO:0090150 establishment of protein localization to membrane 18/770 260/18722 0.0221110549791792 0.165932811688629 TCAF1/EGFR/RAB11A/GOLGA4/BRAF/KRT18/HSPA5/GRIP1/CLN3/ZDHHC3/ZDHHC20/SIL1/VPS37A/RAB7A/GORASP2/CHMP4B/HSP90AA1/STOM 18 GO:0051225 spindle assembly 10/770 117/18722 0.0224658970685976 0.168247212861001 RAB11A/NEK7/GOLGA2/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CHMP4B/CHMP2A 10 GO:0061041 regulation of wound healing 11/770 134/18722 0.0224869845003867 0.168247212861001 ANXA1/ST3GAL4/SERPINB2/SERPINE1/PLPP3/PHLDB2/C1QTNF1/KANK1/CLDN4/NFE2L2/FERMT2 11 GO:0060348 bone development 15/770 205/18722 0.0225421487507544 0.168407087293867 HSD17B1/TFAP2A/TGM2/ANXA6/GLI3/PHOSPHO1/GNAS/SBDS/GHR/MSX2/TRIP11/DLX5/PPIB/INSIG1/PAFAH1B1 15 GO:0070228 regulation of lymphocyte apoptotic process 6/770 54/18722 0.0229315238132662 0.169967489756504 LGALS16/ARG2/CD274/IRS2/FNIP1/PRELID1 6 GO:0072348 sulfur compound transport 6/770 54/18722 0.0229315238132662 0.169967489756504 SLC26A2/SLC13A4/SLC19A2/SLC19A3/SLC5A6/SLC13A3 6 GO:0007004 telomere maintenance via telomerase 7/770 69/18722 0.0229845655787163 0.169967489756504 NEK7/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4/HSP90AA1 7 GO:0031060 regulation of histone methylation 7/770 69/18722 0.0229845655787163 0.169967489756504 GATA3/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/BRD4 7 GO:0045665 negative regulation of neuron differentiation 7/770 69/18722 0.0229845655787163 0.169967489756504 APP/SPAG9/HES1/GLI3/MIB1/CALR/PBX1 7 GO:0045669 positive regulation of osteoblast differentiation 7/770 69/18722 0.0229845655787163 0.169967489756504 CEBPB/GLI3/JUND/CEBPA/CTNNB1/SUCO/FERMT2 7 GO:0032956 regulation of actin cytoskeleton organization 23/770 357/18722 0.0229897828809721 0.169967489756504 RHOBTB1/RASA1/SCIN/MTSS1/SPIRE2/FMN1/WASL/PHLDB2/JMY/PPFIA1/CDC42EP4/SNX9/ARF1/RICTOR/LRP1/KANK1/SLC9A1/NRP1/ARHGAP18/RHOBTB3/TAOK1/FERMT2/IQGAP2 23 GO:0031056 regulation of histone modification 12/770 152/18722 0.0231947518582966 0.171228812607247 UBE2B/GATA3/OTUB2/GATA2/UBR5/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/RPS6KA5/BRD4 12 GO:0006576 cellular biogenic amine metabolic process 9/770 101/18722 0.0232418960065684 0.171323029291021 KMO/GATA3/AKR1B1/SAT1/EPAS1/SMS/MAOA/AZIN1/SLC44A1 9 GO:0048863 stem cell differentiation 15/770 206/18722 0.0234269003154646 0.171591278907003 SEMA6A/HES1/ANXA6/SEMA7A/KRT18/DHX36/FOXO4/PSMD11/CTNNB1/RDH10/NRP1/CHD2/PDCD6/MSI2/NFE2L2 15 GO:0010758 regulation of macrophage chemotaxis 4/770 27/18722 0.0234663581761402 0.171591278907003 MTUS1/AKIRIN1/DDT/MIF 4 GO:0032781 positive regulation of ATPase activity 4/770 27/18722 0.0234663581761402 0.171591278907003 NAPA/DNAJB1/GABARAPL2/TOR1AIP2 4 GO:0032786 positive regulation of DNA-templated transcription, elongation 4/770 27/18722 0.0234663581761402 0.171591278907003 CTNNB1/SUPT6H/BRD4/ALYREF 4 GO:0042402 cellular biogenic amine catabolic process 4/770 27/18722 0.0234663581761402 0.171591278907003 KMO/SAT1/MAOA/SLC44A1 4 GO:0055072 iron ion homeostasis 8/770 85/18722 0.0235248043780074 0.171591278907003 SLC40A1/TFRC/HMOX1/EPAS1/ATP6V1G1/EIF2AK1/ATP6V0D1/SOD1 8 GO:0060021 roof of mouth development 8/770 85/18722 0.0235248043780074 0.171591278907003 TBX3/ARID5B/TFAP2A/GLI3/IRF6/DLX5/INSIG1/TGFBR3 8 GO:0006575 cellular modified amino acid metabolic process 14/770 188/18722 0.0235882051076253 0.171591278907003 CGA/GSTA3/CLIC3/GATA3/GSTA4/SERINC5/SLC6A8/SLC19A1/GGH/MTHFS/CKMT1B/PTDSS1/SOD1/NFE2L2 14 GO:0060491 regulation of cell projection assembly 14/770 188/18722 0.0235882051076253 0.171591278907003 EPS8L1/MYO10/WASL/ARHGAP24/LIMK2/CLN3/SH3YL1/CDC42EP4/AKIRIN1/MIEN1/RAB5A/KANK1/NRP1/CDKL5 14 GO:0009308 amine metabolic process 10/770 118/18722 0.0236775260795486 0.17198995984605 KMO/GATA3/AKR1B1/SAT1/EPAS1/CLN3/SMS/MAOA/AZIN1/SLC44A1 10 GO:0007249 I-kappaB kinase/NF-kappaB signaling 19/770 281/18722 0.02371679119408 0.17202441123741 SQSTM1/HSPB1/TFRC/HMOX1/TGM2/NFKBIA/ERC1/DHX36/PDPK1/CANT1/ZFAND6/CTNNB1/TANK/TBK1/BRD4/SLC20A1/TFG/TMED4/UBE2I 19 GO:0050670 regulation of lymphocyte proliferation 16/770 225/18722 0.023960682471981 0.17354081505506 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/MIF 16 GO:0030833 regulation of actin filament polymerization 13/770 171/18722 0.0245505817487956 0.177555223300796 RASA1/SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/ARHGAP18/IQGAP2 13 GO:0098876 vesicle-mediated transport to the plasma membrane 11/770 136/18722 0.0247710324653621 0.178889934456376 RAB11A/GOLGA4/KRT18/SNX27/EHD3/GRIP1/CLN3/VPS26A/RAB7A/EXOC6B/COMMD1 11 GO:0003229 ventricular cardiac muscle tissue development 6/770 55/18722 0.0248753492564604 0.179383307300929 TBX3/HOPX/DSP/ID2/PPP1R13L/TGFBR3 6 GO:0014031 mesenchymal cell development 8/770 86/18722 0.0250387608430346 0.180040613680868 SEMA6A/HES1/BCL2/ANXA6/SEMA7A/RDH10/NRP1/PDCD6 8 GO:0048864 stem cell development 8/770 86/18722 0.0250387608430346 0.180040613680868 SEMA6A/HES1/ANXA6/SEMA7A/RDH10/NRP1/PDCD6/MSI2 8 GO:0034329 cell junction assembly 26/770 420/18722 0.0255478276236869 0.182783687453699 APP/ZNF703/BCL2/EPB41L3/CLDN7/FMN1/RAP1B/OPHN1/JUP/PHLDB2/DLG5/PDPK1/RAPGEF1/ITGB4/DUSP3/CRB3/CTNNB1/LRP1/SLK/SLC9A1/NRP1/LSR/SORBS1/MPP7/CLDN4/FERMT2 26 GO:0048736 appendage development 13/770 172/18722 0.0256001599920502 0.182783687453699 TBX3/TFAP2A/GLI3/SMOC1/FMN1/IRF6/ITGB4/CTNNB1/DLX5/RDH10/GPC3/PBX1/FERMT2 13 GO:0060173 limb development 13/770 172/18722 0.0256001599920502 0.182783687453699 TBX3/TFAP2A/GLI3/SMOC1/FMN1/IRF6/ITGB4/CTNNB1/DLX5/RDH10/GPC3/PBX1/FERMT2 13 GO:0071470 cellular response to osmotic stress 5/770 41/18722 0.0256036551962035 0.182783687453699 SLC2A1/AKR1B1/CLN3/DDX3X/ERRFI1 5 GO:1905521 regulation of macrophage migration 5/770 41/18722 0.0256036551962035 0.182783687453699 CD200/MTUS1/AKIRIN1/DDT/MIF 5 GO:0032944 regulation of mononuclear cell proliferation 16/770 227/18722 0.025751327395002 0.183311883818247 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/MIF 16 GO:0050671 positive regulation of lymphocyte proliferation 11/770 137/18722 0.0259742023044325 0.183311883818247 ANXA1/TFRC/CD55/VAV3/PNP/HES1/BCL2/CD274/CD46/IRS2/MIF 11 GO:0050714 positive regulation of protein secretion 11/770 137/18722 0.0259742023044325 0.183311883818247 EGFR/EZR/KCNN4/SERP1/ABCG1/PPARD/ARF1/IRS2/DYNLL1/LRP1/OSBP 11 GO:0001732 formation of cytoplasmic translation initiation complex 3/770 16/18722 0.0260039845779572 0.183311883818247 EIF5/EIF2S2/EIF3J 3 GO:0002921 negative regulation of humoral immune response 3/770 16/18722 0.0260039845779572 0.183311883818247 CD55/CD46/CD59 3 GO:0019377 glycolipid catabolic process 3/770 16/18722 0.0260039845779572 0.183311883818247 NEU1/FUCA1/GLA 3 GO:0021783 preganglionic parasympathetic fiber development 3/770 16/18722 0.0260039845779572 0.183311883818247 TFAP2A/HES1/NRP1 3 GO:0071391 cellular response to estrogen stimulus 3/770 16/18722 0.0260039845779572 0.183311883818247 SERPINB9/MDM2/SRA1 3 GO:0003279 cardiac septum development 9/770 103/18722 0.026008730054084 0.183311883818247 TBX3/GATA3/HES1/HECTD1/MDM2/TRIP11/NRP1/TGFBR3/ADAMTS6 9 GO:0045936 negative regulation of phosphate metabolic process 27/770 441/18722 0.0262301563205092 0.184167708095759 PRKCZ/HSPB1/NUPR1/CDKN1C/PDCD4/UBE2B/MLLT1/HEXIM1/FBLN1/SPAG9/PLPP3/SOCS1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/IRS2/GSKIP/DYNLL1/AKT1S1/LRP1/TSG101/SNX6/ERRFI1/DNAJA1 27 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/770 209/18722 0.0262376720548545 0.184167708095759 PMAIP1/SIAH2/IFI6/HERPUD1/VCP/SERPINB9/MDM2/DDX3X/FNIP1/DNAJB6/PDCD6/USP47/TNFAIP8/HSPE1/HSPD1 15 GO:0030218 erythrocyte differentiation 10/770 120/18722 0.0262410340654201 0.184167708095759 GATA3/ALAS1/EPAS1/BPGM/GATA2/ID2/SLC25A5/HSPA1B/TGFBR3/UBA5 10 GO:0003281 ventricular septum development 7/770 71/18722 0.0264286897438981 0.184766240486653 TBX3/GATA3/HES1/HECTD1/MDM2/TRIP11/TGFBR3 7 GO:0071230 cellular response to amino acid stimulus 7/770 71/18722 0.0264286897438981 0.184766240486653 CEBPB/SLC38A9/CPEB4/SH3BP4/RRAGC/UBR1/SOCS1 7 GO:0006972 hyperosmotic response 4/770 28/18722 0.0265117122111092 0.184766240486653 SLC2A1/AKR1B1/PDPK1/ERRFI1 4 GO:0032607 interferon-alpha production 4/770 28/18722 0.0265117122111092 0.184766240486653 DHX36/DDX3X/TBK1/HSPD1 4 GO:0032647 regulation of interferon-alpha production 4/770 28/18722 0.0265117122111092 0.184766240486653 DHX36/DDX3X/TBK1/HSPD1 4 GO:0010469 regulation of signaling receptor activity 13/770 173/18722 0.0266824123698613 0.185696174356172 CGA/PHLDA2/GREM2/NCOA3/APP/SERPINE1/LRPAP1/AKAP9/KLHL24/TSG101/SNX6/NRP1/ERRFI1 13 GO:0090287 regulation of cellular response to growth factor stimulus 20/770 304/18722 0.0267557651892757 0.185834462986966 DAB2/CDKN1C/SEMA6A/GREM2/GATA3/PEG10/ZNF703/CD63/HES1/CRIM1/BCL9L/HSPA5/LATS2/PDPK1/NUMA1/CTNNB1/SNX6/GPC3/PDCD6/TGFBR3 20 GO:0009410 response to xenobiotic stimulus 28/770 462/18722 0.0268368240531613 0.185834462986966 ANXA1/PGF/GSTA3/TFRC/HMOX1/UBE2B/HSD11B2/EGFR/GATA3/VAV3/CYP2J2/GSTA4/GNA12/PNP/BCL2/GGH/RAP1B/HSPA5/DVL3/PLIN2/MDM2/CALR/MYO6/RPN2/USP47/SOD1/NFE2L2/HSPD1 28 GO:0010563 negative regulation of phosphorus metabolic process 27/770 442/18722 0.0268906548898784 0.185834462986966 PRKCZ/HSPB1/NUPR1/CDKN1C/PDCD4/UBE2B/MLLT1/HEXIM1/FBLN1/SPAG9/PLPP3/SOCS1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/IRS2/GSKIP/DYNLL1/AKT1S1/LRP1/TSG101/SNX6/ERRFI1/DNAJA1 27 GO:0001658 branching involved in ureteric bud morphogenesis 6/770 56/18722 0.0269260450083463 0.185834462986966 BCL2/LGR4/GLI3/CTNNB1/GPC3/PBX1 6 GO:0071385 cellular response to glucocorticoid stimulus 6/770 56/18722 0.0269260450083463 0.185834462986966 ANXA1/EGFR/FBXO32/SERPINF1/ERRFI1/USP8 6 GO:1990089 response to nerve growth factor 6/770 56/18722 0.0269260450083463 0.185834462986966 APP/HSPA5/PDPK1/RAPGEF1/EIF4A3/USP8 6 GO:0051098 regulation of binding 23/770 363/18722 0.0271961760540908 0.187338116165583 DAB2/HMOX1/PHLDA2/GREM2/GATA3/HOPX/APP/HES1/DDIT3/NFKBIA/HDAC5/LRPAP1/GOLGA2/MSX2/EDF1/GTF2B/CTNNB1/CSNK1A1/LRP1/EIF4A3/CSNK1E/NRP1/TGFBR3 23 GO:0032946 positive regulation of mononuclear cell proliferation 11/770 138/18722 0.0272191041749713 0.187338116165583 ANXA1/TFRC/CD55/VAV3/PNP/HES1/BCL2/CD274/CD46/IRS2/MIF 11 GO:0006892 post-Golgi vesicle-mediated transport 9/770 104/18722 0.0274760724232054 0.188186249828522 GOLGA4/KRT18/EHD3/AP2A1/CLN3/SNAP23/EXOC6B/RP2/COMMD1 9 GO:0046634 regulation of alpha-beta T cell activation 9/770 104/18722 0.0274760724232054 0.188186249828522 ANXA1/PRKCZ/GATA3/CD55/ARG2/PNP/GLI3/SOCS1/CD274 9 GO:0016570 histone modification 28/770 463/18722 0.0274933955198001 0.188186249828522 UBE2B/GATA3/OTUB2/SIN3B/NCOA3/HOPX/RYBP/UBE2A/MBD3/HDAC5/GATA2/UBR5/ATXN7/KMT2C/TET2/GTF2B/SKP1/MLLT6/LMNA/DDB1/CDK2/KDM5B/CTNNB1/SUPT6H/IWS1/RPS6KA5/BRD4/USP16 28 GO:0023061 signal release 28/770 463/18722 0.0274933955198001 0.188186249828522 CGA/CYP19A1/TBX3/ANXA1/KMO/EGFR/GATA3/PIM3/SERP1/RAP1B/SYT7/ABCG1/RAB1A/NAPA/PPARD/IRS2/KDM5B/C1QTNF1/DYNLL1/SYNJ1/LRP1/RAB5A/OSBP/CCDC186/STXBP3/SNAP23/RAB11FIP1/ADM 28 GO:0030336 negative regulation of cell migration 22/770 344/18722 0.0276655405670099 0.189104785521825 HMOX1/TCAF1/SERPINE1/GNA12/BCL2/CD200/HDAC5/WASL/JUP/PHLDB2/PPARD/DLG5/ADGRG1/DUSP3/DDT/LRP1/CALR/KANK1/MIF/SERPINF1/RAP2C/NFE2L2 22 GO:0014912 negative regulation of smooth muscle cell migration 5/770 42/18722 0.028112817680246 0.191636348154125 SERPINE1/GNA12/PPARD/LRP1/NFE2L2 5 GO:0030890 positive regulation of B cell proliferation 5/770 42/18722 0.028112817680246 0.191636348154125 TFRC/VAV3/BCL2/IRS2/MIF 5 GO:0045598 regulation of fat cell differentiation 11/770 139/18722 0.0285064480705287 0.194054140348968 CEBPB/GATA3/HES1/DDIT3/GATA2/ID2/CEBPA/PPARD/SYAP1/INSIG1/FERMT2 11 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 17/770 249/18722 0.0287932819036211 0.195488435358631 SQSTM1/HSPB1/TFRC/HMOX1/TGM2/DHX36/PDPK1/CANT1/ZFAND6/CTNNB1/TANK/TBK1/BRD4/SLC20A1/TFG/TMED4/UBE2I 17 GO:0051348 negative regulation of transferase activity 18/770 268/18722 0.0287956073757245 0.195488435358631 HSPB1/CDKN1C/PDCD4/MLLT1/HEXIM1/PKIB/CEBPA/LATS2/MVP/PDPK1/DUSP3/IRS2/GSKIP/AKT1S1/TSG101/SNX6/ERRFI1/DNAJA1 18 GO:0001666 response to hypoxia 20/770 307/18722 0.0292713076544761 0.198447518424836 PGF/HMOX1/PMAIP1/SLC2A1/HSD11B2/BCL2/EPAS1/P4HB/PPARD/MDM2/LMNA/EGLN2/MALAT1/SLC9A1/UBQLN1/SLC2A8/TGFBR3/ADM/NFE2L2/HSPD1 20 GO:0034599 cellular response to oxidative stress 19/770 288/18722 0.0295546945596945 0.198671268814293 ANXA1/HSPB1/HMOX1/EGFR/BCL2/EPAS1/MAP1LC3A/OSER1/ERN1/P4HB/PNPLA8/MDM2/CTNNB1/GSKIP/HSPA1B/UBQLN1/STAU1/SOD1/NFE2L2 19 GO:0046651 lymphocyte proliferation 19/770 288/18722 0.0295546945596945 0.198671268814293 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/TBK1/MIF/HSPD1/CCND3 19 GO:0050727 regulation of inflammatory response 24/770 386/18722 0.0296625902947259 0.198671268814293 ANXA1/NUPR1/PDCD4/EGFR/CEBPB/GATA3/APP/SERPINE1/TGM2/SEMA7A/CD200/NFKBIA/FURIN/CEBPA/PPARD/NEAT1/DDT/LDLR/RICTOR/PSMB4/BRD4/SERPINF1/SOD1/HSPD1 24 GO:0009310 amine catabolic process 4/770 29/18722 0.0297827489071397 0.198671268814293 KMO/SAT1/MAOA/SLC44A1 4 GO:0010955 negative regulation of protein processing 4/770 29/18722 0.0297827489071397 0.198671268814293 SERPINE1/MDM2/TMEM59/CAST 4 GO:0021522 spinal cord motor neuron differentiation 4/770 29/18722 0.0297827489071397 0.198671268814293 GLI3/CLN8/SCYL1/GIGYF2 4 GO:0030970 retrograde protein transport, ER to cytosol 4/770 29/18722 0.0297827489071397 0.198671268814293 HERPUD1/VCP/EDEM1/ERLEC1 4 GO:0040018 positive regulation of multicellular organism growth 4/770 29/18722 0.0297827489071397 0.198671268814293 EZR/BCL2/GHR/PPIB 4 GO:0043153 entrainment of circadian clock by photoperiod 4/770 29/18722 0.0297827489071397 0.198671268814293 ID2/BHLHE40/NR2F6/PPP1CB 4 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 4/770 29/18722 0.0297827489071397 0.198671268814293 PTTG1IP/BCL2/MDM2/MIF 4 GO:1903318 negative regulation of protein maturation 4/770 29/18722 0.0297827489071397 0.198671268814293 SERPINE1/MDM2/TMEM59/CAST 4 GO:1903513 endoplasmic reticulum to cytosol transport 4/770 29/18722 0.0297827489071397 0.198671268814293 HERPUD1/VCP/EDEM1/ERLEC1 4 GO:0010634 positive regulation of epithelial cell migration 13/770 176/18722 0.0301304884035365 0.200706041432651 ANXA1/HSPB1/HMOX1/PIK3C2A/GATA3/RAB11A/PLPP3/GATA2/PDPK1/CALR/NRP1/PDCD6/NFE2L2 13 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 7/770 73/18722 0.0302086155076235 0.200706041432651 PIM3/ABCG1/PPARD/DYNLL1/LRP1/OSBP/CCDC186 7 GO:0035924 cellular response to vascular endothelial growth factor stimulus 7/770 73/18722 0.0302086155076235 0.200706041432651 ANXA1/PGF/HSPB1/SEMA6A/CD63/ERN1/NRP1 7 GO:0051651 maintenance of location in cell 15/770 213/18722 0.0303660385207075 0.2014833155109 SCIN/DDIT3/ANXA6/AKAP9/P2RY6/HSPA5/RER1/KDELR2/SKP1/PDPK1/UVRAG/CALR/KDELR1/INSIG1/PAFAH1B1 15 GO:0009100 glycoprotein metabolic process 24/770 387/18722 0.0304463206513313 0.201747361443595 ST3GAL4/BACE2/B3GNT5/CTSL/MAN1A2/C1GALT1/BCL2/GOLGA2/SERP1/TUSC3/RAB1A/EDEM1/TET2/PPARD/GLCE/CHPF/CANT1/TRIP11/MAN1C1/CTNNB1/AGO2/RPN2/TMEM59/DDOST 24 GO:0035518 histone H2A monoubiquitination 3/770 17/18722 0.0306331733191145 0.201762512516459 RYBP/SKP1/DDB1 3 GO:0048532 anatomical structure arrangement 3/770 17/18722 0.0306331733191145 0.201762512516459 TFAP2A/HSPA5/NRP1 3 GO:0061450 trophoblast cell migration 3/770 17/18722 0.0306331733191145 0.201762512516459 ITGB4/CALR/AGO2 3 GO:0010171 body morphogenesis 5/770 43/18722 0.0307725284993997 0.201762512516459 ARID5B/GREM2/PHLDB2/DLX5/GPC3 5 GO:0014002 astrocyte development 5/770 43/18722 0.0307725284993997 0.201762512516459 EGFR/BACE2/APP/LDLR/LRP1 5 GO:0032365 intracellular lipid transport 5/770 43/18722 0.0307725284993997 0.201762512516459 ARL8B/SYT7/ABCG1/LDLR/OSBP 5 GO:0046636 negative regulation of alpha-beta T cell activation 5/770 43/18722 0.0307725284993997 0.201762512516459 ANXA1/ARG2/GLI3/SOCS1/CD274 5 GO:0120178 steroid hormone biosynthetic process 5/770 43/18722 0.0307725284993997 0.201762512516459 CYP19A1/HSD17B1/CYP11A1/AKR1B1/ADM 5 GO:0070372 regulation of ERK1 and ERK2 cascade 20/770 309/18722 0.0310446461184402 0.203279200536383 PRKCZ/SEMA6A/EGFR/EZR/FBLN1/ATF3/APP/DUSP9/BRAF/SEMA7A/RAP1B/P2RY6/DUSP3/DDT/LRP1/GAREM1/NRP1/MIF/ERRFI1/FERMT2 20 GO:0001954 positive regulation of cell-matrix adhesion 6/770 58/18722 0.0313559616463558 0.204511461889779 PRKCZ/FMN1/JUP/UTRN/NRP1/FERMT2 6 GO:0010559 regulation of glycoprotein biosynthetic process 6/770 58/18722 0.0313559616463558 0.204511461889779 BACE2/BCL2/GOLGA2/CTNNB1/AGO2/TMEM59 6 GO:0043506 regulation of JUN kinase activity 6/770 58/18722 0.0313559616463558 0.204511461889779 PDCD4/ERN1/DVL3/MAP3K13/MAP3K4/DNAJA1 6 GO:0034109 homotypic cell-cell adhesion 8/770 90/18722 0.0317745565524322 0.206970738955254 HSPB1/ZNF703/DSP/PLPP3/GNAS/JUP/C1QTNF1/STXBP3 8 GO:0006091 generation of precursor metabolites and energy 29/770 490/18722 0.0321903755526111 0.209405537047861 CYP19A1/NUPR1/PHLDA2/FDX1/APP/AKR1B1/NDUFA6/COQ10B/BPGM/ACSS1/STK40/VCP/COX6C/OPN3/CEBPA/IL10RB/PPARD/IRS2/ACADVL/PRELID1/ACO2/COX4I1/SORBS1/GHITM/COX17/COX7B/COX6A1/NDUFB9/PPP1CB 29 GO:0032943 mononuclear cell proliferation 19/770 291/18722 0.0323625617237528 0.210251166974524 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/TBK1/MIF/HSPD1/CCND3 19 GO:0048872 homeostasis of number of cells 18/770 272/18722 0.032657005837574 0.211887838657072 ANXA1/HMOX1/PMAIP1/GATA3/ALAS1/BCL2/EPAS1/LGR4/BPGM/GATA2/ID2/SLC25A5/ADGRG1/GIGYF2/HSPA1B/TGFBR3/UBA5/SOD1 18 GO:0008654 phospholipid biosynthetic process 17/770 253/18722 0.032817764012955 0.21265398969643 PIK3C2A/SERINC5/ABHD5/SAMD8/ABHD3/SOCS1/ISYNA1/CLN3/TTC7B/SH3YL1/PPARD/IDI1/PI4K2A/SYNJ1/PTDSS1/SLC44A1/TMEM150A 17 GO:0006884 cell volume homeostasis 4/770 30/18722 0.0332817064985096 0.214267110441955 KCNN4/CLCN3/CLN3/SLC12A4 4 GO:0007176 regulation of epidermal growth factor-activated receptor activity 4/770 30/18722 0.0332817064985096 0.214267110441955 APP/TSG101/SNX6/ERRFI1 4 GO:0051125 regulation of actin nucleation 4/770 30/18722 0.0332817064985096 0.214267110441955 SCIN/FMN1/WASL/ARF1 4 GO:0140058 neuron projection arborization 4/770 30/18722 0.0332817064985096 0.214267110441955 GRIP1/DVL3/MAP3K13/NRP1 4 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 4/770 30/18722 0.0332817064985096 0.214267110441955 ERN1/DNAJB9/HSPA5/TMEM33 4 GO:0021517 ventral spinal cord development 5/770 44/18722 0.0335849293216802 0.215262908970175 GLI3/GATA2/CLN8/SCYL1/GIGYF2 5 GO:0032007 negative regulation of TOR signaling 5/770 44/18722 0.0335849293216802 0.215262908970175 SH3BP4/UBR1/FNIP1/AKT1S1/PDCD6 5 GO:0032881 regulation of polysaccharide metabolic process 5/770 44/18722 0.0335849293216802 0.215262908970175 PHLDA2/AP2A1/IRS2/SORBS1/PPP1CB 5 GO:0001836 release of cytochrome c from mitochondria 6/770 59/18722 0.0337387782271135 0.215262908970175 PMAIP1/BCL2/IFI6/LMNA/PRELID1/GHITM 6 GO:0046324 regulation of glucose import 6/770 59/18722 0.0337387782271135 0.215262908970175 OPN3/IRS2/STXBP3/GPC3/SORBS1/NFE2L2 6 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 6/770 59/18722 0.0337387782271135 0.215262908970175 PRKCZ/SOCS1/MVP/TSG101/SNX6/ERRFI1 6 GO:2000351 regulation of endothelial cell apoptotic process 6/770 59/18722 0.0337387782271135 0.215262908970175 PDCD4/GATA3/SERPINE1/GATA2/PDPK1/NFE2L2 6 GO:2000116 regulation of cysteine-type endopeptidase activity 16/770 235/18722 0.0339265943297671 0.216184423970882 PMAIP1/SIAH2/IFI6/HERPUD1/VCP/SERPINB9/MDM2/DDX3X/FNIP1/DNAJB6/PDCD6/USP47/TNFAIP8/HSPE1/HSPD1/CAST 16 GO:0006278 RNA-dependent DNA biosynthetic process 7/770 75/18722 0.034336149141204 0.218236009146198 NEK7/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4/HSP90AA1 7 GO:0043627 response to estrogen 7/770 75/18722 0.034336149141204 0.218236009146198 HMOX1/GATA3/GLI3/SERPINB9/MDM2/SRA1/HSPD1 7 GO:0031099 regeneration 14/770 198/18722 0.0345819345566728 0.219518190950192 ANXA1/PGF/HMOX1/EGFR/CEBPB/HOPX/BCL2/GLI3/PPARD/AKIRIN1/SRSF5/LRP1/TGFBR3/ADM 14 GO:0045787 positive regulation of cell cycle 20/770 313/18722 0.03483113524163 0.220818761970792 TBX3/ANXA1/NUPR1/UBE2B/EGFR/RAB11A/OVOL1/APP/HES1/MDM2/DUSP3/NUMA1/DDX3X/PPP1R10/VPS4B/CALR/BRD4/PBX1/PAFAH1B1/CCND3 20 GO:0033135 regulation of peptidyl-serine phosphorylation 11/770 144/18722 0.0356036308914108 0.222423019110973 TFRC/EGFR/APP/BCL2/BRAF/AKAP9/FNIP1/RICTOR/TBK1/MIF/HSP90AA1 11 GO:0006595 polyamine metabolic process 3/770 18/18722 0.0356644576098068 0.222423019110973 SAT1/SMS/AZIN1 3 GO:0030730 sequestering of triglyceride 3/770 18/18722 0.0356644576098068 0.222423019110973 ABHD5/PLIN2/PNPLA2 3 GO:0032634 interleukin-5 production 3/770 18/18722 0.0356644576098068 0.222423019110973 PRKCZ/GATA3/TNFRSF21 3 GO:0032674 regulation of interleukin-5 production 3/770 18/18722 0.0356644576098068 0.222423019110973 PRKCZ/GATA3/TNFRSF21 3 GO:0036507 protein demannosylation 3/770 18/18722 0.0356644576098068 0.222423019110973 MAN1A2/EDEM1/MAN1C1 3 GO:0036508 protein alpha-1,2-demannosylation 3/770 18/18722 0.0356644576098068 0.222423019110973 MAN1A2/EDEM1/MAN1C1 3 GO:0048268 clathrin coat assembly 3/770 18/18722 0.0356644576098068 0.222423019110973 PIK3C2A/CLTA/CLTB 3 GO:0048486 parasympathetic nervous system development 3/770 18/18722 0.0356644576098068 0.222423019110973 TFAP2A/HES1/NRP1 3 GO:0055070 copper ion homeostasis 3/770 18/18722 0.0356644576098068 0.222423019110973 APP/ARF1/COMMD1 3 GO:0097094 craniofacial suture morphogenesis 3/770 18/18722 0.0356644576098068 0.222423019110973 GLI3/MSX2/INSIG1 3 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 3/770 18/18722 0.0356644576098068 0.222423019110973 TBX3/HES1/CTNNB1 3 GO:2000641 regulation of early endosome to late endosome transport 3/770 18/18722 0.0356644576098068 0.222423019110973 DAB2/EZR/RAB21 3 GO:0045685 regulation of glial cell differentiation 7/770 76/18722 0.0365335985511103 0.226706679135187 SPINT1/HES1/ID2/TNFRSF21/CTNNB1/LDLR/RHEB 7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 7/770 76/18722 0.0365335985511103 0.226706679135187 NUPR1/PMAIP1/PTTG1IP/BCL2/JMY/MDM2/MIF 7 GO:0044088 regulation of vacuole organization 5/770 45/18722 0.0365518631220047 0.226706679135187 NUPR1/FEZ2/RAB5A/CHMP4B/TMEM106B 5 GO:1901985 positive regulation of protein acetylation 5/770 45/18722 0.0365518631220047 0.226706679135187 GATA3/DIP2B/DDX3X/RPS6KA5/TAOK1 5 GO:1905952 regulation of lipid localization 13/770 181/18722 0.0365788019315051 0.226706679135187 CYP19A1/ABHD5/NFKBIA/FURIN/ABCG1/PLIN2/PPARD/IRS2/KDM5B/C1QTNF1/PRELID1/LRP1/PNPLA2 13 GO:0002828 regulation of type 2 immune response 4/770 31/18722 0.0370101175705605 0.227070671306467 ANXA1/PRKCZ/GATA3/ARG2 4 GO:0006301 postreplication repair 4/770 31/18722 0.0370101175705605 0.227070671306467 UBE2B/UBE2A/VCP/USP43 4 GO:0035115 embryonic forelimb morphogenesis 4/770 31/18722 0.0370101175705605 0.227070671306467 TBX3/TFAP2A/CTNNB1/RDH10 4 GO:0061099 negative regulation of protein tyrosine kinase activity 4/770 31/18722 0.0370101175705605 0.227070671306467 MVP/TSG101/SNX6/ERRFI1 4 GO:1900027 regulation of ruffle assembly 4/770 31/18722 0.0370101175705605 0.227070671306467 EPS8L1/ARHGAP24/SH3YL1/KANK1 4 GO:1901797 negative regulation of signal transduction by p53 class mediator 4/770 31/18722 0.0370101175705605 0.227070671306467 PTTG1IP/BCL2/MDM2/MIF 4 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/770 31/18722 0.0370101175705605 0.227070671306467 HMOX1/SERPINE1/DDX3X/TMBIM1 4 GO:2000144 positive regulation of DNA-templated transcription, initiation 4/770 31/18722 0.0370101175705605 0.227070671306467 MED13/DHX36/SUB1/PSMC6 4 GO:0010976 positive regulation of neuron projection development 12/770 163/18722 0.0370476531752273 0.227070671306467 CREB3L2/DHX36/AP2A1/HSPA5/TENM3/RAPGEF1/ATF1/LRP1/SERPINF1/PAFAH1B1/TMEM106B/NFE2L2 12 GO:0045216 cell-cell junction organization 14/770 200/18722 0.0371626193193201 0.227495493941243 SVEP1/ZNF703/DSP/GRHL1/EPB41L3/CLDN7/MTSS1/JUP/DLG5/CTNNB1/LSR/MPP7/CLDN4/FERMT2 14 GO:0045185 maintenance of protein location 8/770 93/18722 0.0375729906472549 0.229443887739303 SCIN/NFKBIA/HSPA5/RER1/KDELR2/SKP1/KDELR1/INSIG1 8 GO:0097306 cellular response to alcohol 8/770 93/18722 0.0375729906472549 0.229443887739303 FDX1/GNAI1/GRAMD1C/P2RY6/JUP/MDM2/XRN1/CTNNB1 8 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 10/770 128/18722 0.0384866130770209 0.234735364703544 DAB2/CDKN1C/PEG10/ZNF703/BCL9L/HSPA5/LATS2/PDPK1/SNX6/TGFBR3 10 GO:0048705 skeletal system morphogenesis 15/770 220/18722 0.0387089291953596 0.234926666309163 ARID5B/TFAP2A/ANXA6/GLI3/PHOSPHO1/GHR/MSX2/FMN1/TRIP11/CTNNB1/DLX5/EIF4A3/RDH10/INSIG1/ZFAND5 15 GO:0042542 response to hydrogen peroxide 11/770 146/18722 0.0387627546919064 0.234926666309163 ANXA1/HMOX1/SDC1/BCL2/MAP1LC3A/OSER1/ERN1/MDM2/SOD1/NFE2L2/HSPD1 11 GO:0010827 regulation of glucose transmembrane transport 7/770 77/18722 0.0388217730141117 0.234926666309163 BRAF/OPN3/IRS2/STXBP3/GPC3/SORBS1/NFE2L2 7 GO:1901983 regulation of protein acetylation 7/770 77/18722 0.0388217730141117 0.234926666309163 GATA3/GATA2/DIP2B/DDX3X/IWS1/RPS6KA5/TAOK1 7 GO:0030865 cortical cytoskeleton organization 6/770 61/18722 0.038847997800271 0.234926666309163 RHOBTB1/EZR/EPB41L3/CALR/PAFAH1B1/RHOBTB3 6 GO:0043030 regulation of macrophage activation 6/770 61/18722 0.038847997800271 0.234926666309163 CD200/JUND/CEBPA/LDLR/MIF/HSPD1 6 GO:0071384 cellular response to corticosteroid stimulus 6/770 61/18722 0.038847997800271 0.234926666309163 ANXA1/EGFR/FBXO32/SERPINF1/ERRFI1/USP8 6 GO:0009101 glycoprotein biosynthetic process 20/770 317/18722 0.0389498508054452 0.235257098864889 ST3GAL4/BACE2/B3GNT5/MAN1A2/C1GALT1/BCL2/GOLGA2/SERP1/TUSC3/TET2/GLCE/CHPF/CANT1/TRIP11/MAN1C1/CTNNB1/AGO2/RPN2/TMEM59/DDOST 20 GO:0032386 regulation of intracellular transport 21/770 337/18722 0.0391820597079353 0.236373127753803 DAB2/TCAF1/EZR/GLI3/JUP/LEPROT/UBR5/TBC1D20/EDEM1/SAR1A/MDM2/ERLEC1/RAB21/ARF1/NUMA1/SUPT6H/SAR1B/IWS1/INSIG1/STOM/REEP5 21 GO:0006984 ER-nucleus signaling pathway 5/770 46/18722 0.0396748738426558 0.237935381086977 DDIT3/HSPA5/TMEM33/INSIG1/NFE2L2 5 GO:0031057 negative regulation of histone modification 5/770 46/18722 0.0396748738426558 0.237935381086977 UBE2B/OTUB2/UBR5/MLLT6/SUPT6H 5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 5/770 46/18722 0.0396748738426558 0.237935381086977 ANXA1/EGFR/MDM2/DDX3X/CCND3 5 GO:1900271 regulation of long-term synaptic potentiation 5/770 46/18722 0.0396748738426558 0.237935381086977 SQSTM1/APP/MME/PAIP2/STAU1 5 GO:0048511 rhythmic process 19/770 298/18722 0.0396797715599595 0.237935381086977 EGFR/TOP1/SIAH2/LGR4/JUND/ID2/HSPA5/NFIL3/OPN3/BHLHE40/GPR157/NR2F6/DDB1/KDM5B/CSNK1E/PHLPP1/SERPINF1/CLDN4/PPP1CB 19 GO:0007409 axonogenesis 25/770 418/18722 0.0399216254353251 0.238932708872333 SIAH1/SEMA6A/EIF4G2/GATA3/RAB11A/GOLGA4/APP/EPHB4/BCL2/GLI3/SEMA7A/OPHN1/DIP2B/LAMC2/RAB21/FEZ2/DLX5/BSG/LRP1/RPS6KA5/MAP3K13/NRP1/HSP90AA1/PAFAH1B1/CDKL5 25 GO:0015980 energy derivation by oxidation of organic compounds 20/770 318/18722 0.0400331440382441 0.238932708872333 NUPR1/PHLDA2/NDUFA6/COQ10B/STK40/VCP/COX6C/OPN3/IL10RB/IRS2/ACADVL/PRELID1/ACO2/COX4I1/SORBS1/GHITM/COX7B/COX6A1/NDUFB9/PPP1CB 20 GO:0046661 male sex differentiation 12/770 165/18722 0.0400858407821133 0.238932708872333 TBX3/ARID5B/NUPR1/GATA3/SDC1/BCL2/LGR4/TBC1D20/EIF2S2/ADGRG1/CTNNB1/RHOBTB3 12 GO:0071772 response to BMP 12/770 165/18722 0.0400858407821133 0.238932708872333 GDF15/PDCD4/GREM2/GATA3/SPINT1/HES1/CRIM1/SPINT2/NUMA1/DLX5/GPC3/TGFBR3 12 GO:0071773 cellular response to BMP stimulus 12/770 165/18722 0.0400858407821133 0.238932708872333 GDF15/PDCD4/GREM2/GATA3/SPINT1/HES1/CRIM1/SPINT2/NUMA1/DLX5/GPC3/TGFBR3 12 GO:0043542 endothelial cell migration 18/770 279/18722 0.0403172034659784 0.240024641422903 ANXA1/HSPB1/S100P/HMOX1/PIK3C2A/GATA3/EPHB4/PLPP3/HDAC5/GATA2/JUP/PDPK1/LGALS8/CALR/NRP1/SERPINF1/PDCD6/NFE2L2 18 GO:0016331 morphogenesis of embryonic epithelium 11/770 147/18722 0.0404133619586012 0.240310003150012 GATA3/TFAP2A/SPINT1/HECTD1/MIB1/DVL3/SPINT2/BRD2/CTNNB1/RDH10/ADM 11 GO:1901990 regulation of mitotic cell cycle phase transition 19/770 299/18722 0.0408162275902407 0.240333501440625 ANXA1/EGFR/NABP1/RAB11A/APP/BCL2/ID2/FOXO4/MDM2/DDB1/CDK2/DDX3X/GIGYF2/VPS4B/BRD4/PBX1/USP47/TAOK1/CCND3 19 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 4/770 32/18722 0.0409688311272415 0.240333501440625 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0021799 cerebral cortex radially oriented cell migration 4/770 32/18722 0.0409688311272415 0.240333501440625 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 4/770 32/18722 0.0409688311272415 0.240333501440625 HEXIM1/CTNNB1/SUPT6H/BRD4 4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 4/770 32/18722 0.0409688311272415 0.240333501440625 CDKN1C/HEXIM1/CEBPA/LATS2 4 GO:0051642 centrosome localization 4/770 32/18722 0.0409688311272415 0.240333501440625 EZR/AKAP9/SYNE2/PAFAH1B1 4 GO:1901532 regulation of hematopoietic progenitor cell differentiation 4/770 32/18722 0.0409688311272415 0.240333501440625 HES1/DHX36/FNIP1/NFE2L2 4 GO:0015802 basic amino acid transport 3/770 19/18722 0.0410925432926776 0.240333501440625 SLC38A9/CLN3/SLC7A6 3 GO:0016082 synaptic vesicle priming 3/770 19/18722 0.0410925432926776 0.240333501440625 NAPA/SYNJ1/SNAP23 3 GO:0030050 vesicle transport along actin filament 3/770 19/18722 0.0410925432926776 0.240333501440625 WASL/MYO6/ACTN4 3 GO:0035313 wound healing, spreading of epidermal cells 3/770 19/18722 0.0410925432926776 0.240333501440625 ARHGAP24/PHLDB2/FERMT2 3 GO:0045947 negative regulation of translational initiation 3/770 19/18722 0.0410925432926776 0.240333501440625 EIF2AK1/PAIP2/AGO2 3 GO:0061323 cell proliferation involved in heart morphogenesis 3/770 19/18722 0.0410925432926776 0.240333501440625 TBX3/HES1/CTNNB1 3 GO:2000369 regulation of clathrin-dependent endocytosis 3/770 19/18722 0.0410925432926776 0.240333501440625 DAB2/AAK1/WASL 3 GO:0032024 positive regulation of insulin secretion 7/770 78/18722 0.0412017634601773 0.240407947683915 SERP1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 7 GO:0070373 negative regulation of ERK1 and ERK2 cascade 7/770 78/18722 0.0412017634601773 0.240407947683915 SEMA6A/EZR/FBLN1/ATF3/DUSP9/DUSP3/ERRFI1 7 GO:0051052 regulation of DNA metabolic process 22/770 359/18722 0.0413510353705217 0.240715197723493 TFRC/UBE2B/EGFR/GATA3/OTUB2/MBD3/SPIRE2/NEK7/DHX36/PKIB/UBR5/ZNF91/TNKS2/XRN1/PPP1R10/CTNNB1/SUPT6H/MAP3K4/HSP90AA1/PPP4R2/SUB1/ALYREF 22 GO:0071900 regulation of protein serine/threonine kinase activity 22/770 359/18722 0.0413510353705217 0.240715197723493 CDKN1C/PDCD4/EGFR/HEXIM1/GHR/ERN1/PKIB/CEBPA/DVL3/LATS2/UVRAG/SYAP1/DDX3X/SERTAD1/RICTOR/TSG101/MAP3K13/MAP3K4/DNAJA1/TAOK1/FERMT2/CCND3 22 GO:0051090 regulation of DNA-binding transcription factor activity 26/770 440/18722 0.0415025954064513 0.241315557655014 PRKCZ/ARID5B/TFRC/NUPR1/HMOX1/SGK1/TAX1BP1/APP/HES1/DDIT3/PLPP3/CD200/NFKBIA/HDAC5/ERC1/ID2/JUP/BHLHE40/JMY/CTNNB1/ANXA4/HSPA1B/RPS6KA5/MAP3K13/COMMD1/COMMD7 26 GO:0032835 glomerulus development 6/770 62/18722 0.0415770898862144 0.241466945108399 BASP1/HES1/BCL2/LGR4/MTSS1/ENPEP 6 GO:0008585 female gonad development 8/770 95/18722 0.041809674460911 0.241690960369744 CYP19A1/ARID5B/NUPR1/CEBPB/BCL2/HSPA5/EIF2B2/SOD1 8 GO:0036473 cell death in response to oxidative stress 8/770 95/18722 0.041809674460911 0.241690960369744 HSPB1/BCL2/P4HB/CTNNB1/GSKIP/UBQLN1/SOD1/NFE2L2 8 GO:0050764 regulation of phagocytosis 8/770 95/18722 0.041809674460911 0.241690960369744 TGM2/DYSF/GATA2/SYT7/LMAN2/LRP1/CALR/SOD1 8 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8/770 95/18722 0.041809674460911 0.241690960369744 SQSTM1/OTUB2/UBR5/CTNNB1/HSPA1B/UBXN1/DNAJA1/HMG20B 8 GO:0015918 sterol transport 10/770 130/18722 0.0420762000703506 0.242949831924168 ARL8B/GRAMD1C/NFKBIA/FURIN/SYT7/ABCG1/VPS4B/LDLR/LRP1/OSBP 10 GO:0006998 nuclear envelope organization 5/770 47/18722 0.0429552072356644 0.246596541077553 LMNA/CHMP4B/PAFAH1B1/CHMP2A/UBE2I 5 GO:0035315 hair cell differentiation 5/770 47/18722 0.0429552072356644 0.246596541077553 HES1/CTNNB1/MYO6/PAFAH1B1/SOD1 5 GO:0048483 autonomic nervous system development 5/770 47/18722 0.0429552072356644 0.246596541077553 GATA3/TFAP2A/HES1/CTNNB1/NRP1 5 GO:0050885 neuromuscular process controlling balance 5/770 47/18722 0.0429552072356644 0.246596541077553 APP/CLN3/CLN8/GIGYF2/PAFAH1B1 5 GO:0051972 regulation of telomerase activity 5/770 47/18722 0.0429552072356644 0.246596541077553 NEK7/PKIB/CTNNB1/MAP3K4/HSP90AA1 5 GO:0042886 amide transport 19/770 301/18722 0.0431598809147737 0.247486405751804 ANXA1/EGFR/SLC19A2/PIM3/SLC19A1/SERP1/SLC5A6/SYT7/ABCG1/RAB1A/PPARD/GLTP/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SLC13A3 19 GO:0055088 lipid homeostasis 12/770 167/18722 0.0432944387669034 0.247687931544753 MYLIP/ABHD5/CEBPA/ABCG1/PNPLA8/CLN8/IRS2/DDX3X/LDLR/PNPLA2/ORMDL1/INSIG1 12 GO:1903034 regulation of response to wounding 12/770 167/18722 0.0432944387669034 0.247687931544753 ANXA1/ST3GAL4/SERPINB2/SERPINE1/PLPP3/PHLDB2/C1QTNF1/LRP1/KANK1/CLDN4/NFE2L2/FERMT2 12 GO:0050678 regulation of epithelial cell proliferation 23/770 381/18722 0.0433632220927083 0.247796944596291 PGF/NUPR1/CDKN1C/HMOX1/EGFR/GATA3/ZNF703/HES1/MTSS1/GATA2/PPARD/PDPK1/KDM5B/CTNNB1/DLX5/RICTOR/NRP1/GPC3/SERPINF1/PDCD6/ERRFI1/TGFBR3/MYDGF 23 GO:0072594 establishment of protein localization to organelle 25/770 422/18722 0.043836025719459 0.250025712047154 RAB11A/PTTG1IP/DDIT3/GLI3/KPNA6/NFKBIA/HERPUD1/JUP/HSPA5/LEPROT/UBR5/EDEM1/LMNA/ZFAND6/PPP1R10/ZFYVE16/TSG101/VPS37A/RAB7A/CHMP4B/HSP90AA1/TNPO1/DNAJA1/HSPA8/HSPD1 25 GO:0009411 response to UV 11/770 149/18722 0.0438594525229587 0.250025712047154 UBE2B/EGFR/BCL2/UBE2A/MME/DHX36/OPN3/MDM2/DDB1/MAP3K4/USP47 11 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 10/770 131/18722 0.0439539481744546 0.250025712047154 GREM2/PEG10/CRIM1/DACT2/BCL9L/HSPA5/PDPK1/LRP1/SNX6/TGFBR3 10 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 10/770 131/18722 0.0439539481744546 0.250025712047154 DAB2/CDKN1C/PEG10/ZNF703/BCL9L/HSPA5/LATS2/PDPK1/SNX6/TGFBR3 10 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 6/770 63/18722 0.0444240367113425 0.252411601975621 PMAIP1/CEBPB/BCL2/DDIT3/ERN1/HERPUD1 6 GO:0009648 photoperiodism 4/770 33/18722 0.0451580368933314 0.254550336922478 ID2/BHLHE40/NR2F6/PPP1CB 4 GO:0031116 positive regulation of microtubule polymerization 4/770 33/18722 0.0451580368933314 0.254550336922478 CLIP1/AKAP9/NUMA1/HSPA1B 4 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 4/770 33/18722 0.0451580368933314 0.254550336922478 MED13/DHX36/SUB1/PSMC6 4 GO:0061842 microtubule organizing center localization 4/770 33/18722 0.0451580368933314 0.254550336922478 EZR/AKAP9/SYNE2/PAFAH1B1 4 GO:0071763 nuclear membrane organization 4/770 33/18722 0.0451580368933314 0.254550336922478 CHMP4B/PAFAH1B1/CHMP2A/UBE2I 4 GO:0150117 positive regulation of cell-substrate junction organization 4/770 33/18722 0.0451580368933314 0.254550336922478 FMN1/DUSP3/NRP1/FERMT2 4 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/770 33/18722 0.0451580368933314 0.254550336922478 CDKN1C/HEXIM1/CEBPA/LATS2 4 GO:0021987 cerebral cortex development 9/770 114/18722 0.0454515313967921 0.255586498449736 TACC2/SLC2A1/GNG12/GLI3/ADGRG1/CTNNB1/LRP1/TACC1/PAFAH1B1 9 GO:0046660 female sex differentiation 9/770 114/18722 0.0454515313967921 0.255586498449736 CYP19A1/TBX3/ARID5B/NUPR1/CEBPB/BCL2/HSPA5/EIF2B2/SOD1 9 GO:0002695 negative regulation of leukocyte activation 13/770 187/18722 0.0455470219994713 0.255586498449736 ANXA1/HMOX1/CEBPB/ARG2/GLI3/CD200/SOCS1/CD274/ID2/TNFRSF21/DLG5/DUSP3/LDLR 13 GO:0008064 regulation of actin polymerization or depolymerization 13/770 187/18722 0.0455470219994713 0.255586498449736 RASA1/SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/ARHGAP18/IQGAP2 13 GO:0070665 positive regulation of leukocyte proliferation 11/770 150/18722 0.045655987900495 0.255909772450131 ANXA1/TFRC/CD55/VAV3/PNP/HES1/BCL2/CD274/CD46/IRS2/MIF 11 GO:0071229 cellular response to acid chemical 7/770 80/18722 0.0462410971761483 0.258898187897468 CEBPB/SLC38A9/CPEB4/SH3BP4/RRAGC/UBR1/SOCS1 7 GO:0002686 negative regulation of leukocyte migration 5/770 48/18722 0.0463938128086326 0.259461693855686 HMOX1/CD200/WASL/DDT/MIF 5 GO:0070663 regulation of leukocyte proliferation 16/770 245/18722 0.0466312613188786 0.260016353459363 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/MIF 16 GO:0006700 C21-steroid hormone biosynthetic process 3/770 20/18722 0.0469104358338285 0.260016353459363 CYP11A1/AKR1B1/ADM 3 GO:0007097 nuclear migration 3/770 20/18722 0.0469104358338285 0.260016353459363 HOOK3/SYNE2/PAFAH1B1 3 GO:0010893 positive regulation of steroid biosynthetic process 3/770 20/18722 0.0469104358338285 0.260016353459363 CGA/ABCG1/ADM 3 GO:0043586 tongue development 3/770 20/18722 0.0469104358338285 0.260016353459363 EGFR/GLI3/CTNNB1 3 GO:0060231 mesenchymal to epithelial transition 3/770 20/18722 0.0469104358338285 0.260016353459363 GATA3/BASP1/CTNNB1 3 GO:0090201 negative regulation of release of cytochrome c from mitochondria 3/770 20/18722 0.0469104358338285 0.260016353459363 LMNA/PRELID1/GHITM 3 GO:0097320 plasma membrane tubulation 3/770 20/18722 0.0469104358338285 0.260016353459363 WASL/SNX9/PLEKHM2 3 GO:0030308 negative regulation of cell growth 13/770 188/18722 0.0471782483971513 0.260356484405246 SEMA6A/SPAG9/BCL2/SH3BP4/SEMA7A/BTG1/SERTAD3/DIP2B/PPARD/DDX3X/RBBP7/HSPA1B/NRP1 13 GO:0030832 regulation of actin filament length 13/770 188/18722 0.0471782483971513 0.260356484405246 RASA1/SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/ARHGAP18/IQGAP2 13 GO:0017156 calcium-ion regulated exocytosis 6/770 64/18722 0.0473897915624239 0.260356484405246 SCIN/ARL8B/RAP1B/SYT7/ARF1/STXBP3 6 GO:0030104 water homeostasis 6/770 64/18722 0.0473897915624239 0.260356484405246 NEDD4L/AKR1B1/GRHL1/CLN3/LSR/CLDN4 6 GO:0030888 regulation of B cell proliferation 6/770 64/18722 0.0473897915624239 0.260356484405246 TFRC/VAV3/BCL2/TNFRSF21/IRS2/MIF 6 GO:0046854 phosphatidylinositol phosphate biosynthetic process 6/770 64/18722 0.0473897915624239 0.260356484405246 PIK3C2A/SOCS1/TTC7B/PI4K2A/SYNJ1/TMEM150A 6 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 6/770 64/18722 0.0473897915624239 0.260356484405246 PIM3/ABCG1/PPARD/DYNLL1/LRP1/OSBP 6 GO:0098930 axonal transport 6/770 64/18722 0.0473897915624239 0.260356484405246 HSPB1/ARL8B/RAB21/ARMCX3/PAFAH1B1/SOD1 6 GO:0048754 branching morphogenesis of an epithelial tube 11/770 151/18722 0.0475021821337527 0.260634772851226 TBX3/BCL2/LGR4/GLI3/DLG5/KDM5B/CTNNB1/RDH10/NRP1/GPC3/PBX1 11 GO:0034968 histone lysine methylation 9/770 115/18722 0.0475973596818414 0.260634772851226 GATA3/KMT2C/TET2/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/BRD4 9 GO:0046916 cellular transition metal ion homeostasis 9/770 115/18722 0.0475973596818414 0.260634772851226 SLC40A1/TFRC/HMOX1/APP/ATP6V1G1/SLC39A7/ATP6V0D1/ARF1/SOD1 9 GO:0046887 positive regulation of hormone secretion 10/770 133/18722 0.0478782950970985 0.261847869250799 CYP19A1/EGFR/SERP1/ABCG1/PPARD/IRS2/C1QTNF1/DYNLL1/LRP1/OSBP 10 GO:0061564 axon development 27/770 467/18722 0.0479239929272986 0.261847869250799 SIAH1/SEMA6A/EIF4G2/GATA3/RAB11A/GOLGA4/APP/EPHB4/BCL2/GLI3/SEMA7A/OPHN1/DIP2B/TNFRSF21/LAMC2/RAB21/FEZ2/DLX5/BSG/LRP1/RPS6KA5/MAP3K13/NRP1/CAMSAP2/HSP90AA1/PAFAH1B1/CDKL5 27 GO:0031668 cellular response to extracellular stimulus 16/770 246/18722 0.0480647123823865 0.262329092882182 HMOX1/PMAIP1/SLC2A1/MAP1LC3B/GABARAPL1/ATF3/BCL2/CPEB4/MAP1LC3A/RRAGC/HSPA5/MDM2/FNIP1/GABARAPL2/HSPA8/NFE2L2 16 GO:0007411 axon guidance 15/770 227/18722 0.0485829222962056 0.264577816177041 SIAH1/SEMA6A/GATA3/APP/EPHB4/GLI3/SEMA7A/OPHN1/LAMC2/FEZ2/DLX5/BSG/LRP1/RPS6KA5/NRP1 15 GO:0046777 protein autophosphorylation 15/770 227/18722 0.0485829222962056 0.264577816177041 EGFR/PIM3/EPHB4/AAK1/EIF2AK1/ERN1/MVP/PDPK1/DDX3X/SLK/MAP3K13/RAP2C/ERRFI1/CDKL5/TAOK1 15 GO:0014032 neural crest cell development 7/770 81/18722 0.0489021589901102 0.265446032949585 SEMA6A/HES1/ANXA6/SEMA7A/RDH10/NRP1/PDCD6 7 GO:0051817 modulation of process of other organism involved in symbiotic interaction 7/770 81/18722 0.0489021589901102 0.265446032949585 RAB9A/SERPINB9/TBC1D20/PPIB/PSMC3/STOM/HSPA8 7 GO:2000106 regulation of leukocyte apoptotic process 7/770 81/18722 0.0489021589901102 0.265446032949585 ANXA1/LGALS16/ARG2/CD274/IRS2/FNIP1/PRELID1 7 GO:0016242 negative regulation of macroautophagy 4/770 34/18722 0.049577291451638 0.267856861381002 NUPR1/HMOX1/FEZ2/CHMP4B 4 GO:0035137 hindlimb morphogenesis 4/770 34/18722 0.049577291451638 0.267856861381002 TBX3/FMN1/CTNNB1/GPC3 4 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 4/770 34/18722 0.049577291451638 0.267856861381002 PMAIP1/PTTG1IP/MDM2/MIF 4 GO:0070232 regulation of T cell apoptotic process 4/770 34/18722 0.049577291451638 0.267856861381002 LGALS16/ARG2/CD274/PRELID1 4 GO:0008286 insulin receptor signaling pathway 9/770 116/18722 0.0498093007868744 0.267856861381002 PRKCZ/PIK3C2A/SOCS1/FOXO4/IRS2/KANK1/SORBS1/SLC2A8/CCND3 9 GO:0010823 negative regulation of mitochondrion organization 5/770 49/18722 0.0499913467959726 0.267856861381002 TFRC/SLC25A5/LMNA/PRELID1/GHITM 5 GO:0021515 cell differentiation in spinal cord 5/770 49/18722 0.0499913467959726 0.267856861381002 GLI3/GATA2/CLN8/SCYL1/GIGYF2 5 GO:0030225 macrophage differentiation 5/770 49/18722 0.0499913467959726 0.267856861381002 APP/EIF2AK1/GATA2/ID2/CEBPA 5 GO:0038084 vascular endothelial growth factor signaling pathway 5/770 49/18722 0.0499913467959726 0.267856861381002 PGF/HSPB1/SEMA6A/CD63/NRP1 5 GO:0043457 regulation of cellular respiration 5/770 49/18722 0.0499913467959726 0.267856861381002 NUPR1/VCP/OPN3/IL10RB/PRELID1 5 GO:0048168 regulation of neuronal synaptic plasticity 5/770 49/18722 0.0499913467959726 0.267856861381002 RAB11A/APP/CLN3/SYAP1/RAB5A 5 GO:0060986 endocrine hormone secretion 5/770 49/18722 0.0499913467959726 0.267856861381002 CGA/TBX3/GATA3/C1QTNF1/RAB11FIP1 5 GO:0097485 neuron projection guidance 15/770 228/18722 0.0501251453315421 0.268285283766997 SIAH1/SEMA6A/GATA3/APP/EPHB4/GLI3/SEMA7A/OPHN1/LAMC2/FEZ2/DLX5/BSG/LRP1/RPS6KA5/NRP1 15 GO:0042129 regulation of T cell proliferation 12/770 171/18722 0.0502375553511913 0.268310544817778 ANXA1/TFRC/CEBPB/CD55/ARG2/PNP/HES1/CD274/TNFRSF21/DLG5/CD46/CTNNB1 12 GO:0046890 regulation of lipid biosynthetic process 12/770 171/18722 0.0502375553511913 0.268310544817778 CGA/ANXA1/SAMD8/ABCG1/ACADVL/LDLR/RDH10/ORMDL1/INSIG1/SORBS1/ADM/SOD1 12 GO:0002720 positive regulation of cytokine production involved in immune response 6/770 65/18722 0.0504751495108806 0.268599734992567 PRKCZ/GATA3/CD55/SLC7A5/SEMA7A/DHX36 6 GO:0070936 protein K48-linked ubiquitination 6/770 65/18722 0.0504751495108806 0.268599734992567 UBE2B/NEDD4L/UBE2A/UBR5/SKP1/UBE2H 6 GO:0072577 endothelial cell apoptotic process 6/770 65/18722 0.0504751495108806 0.268599734992567 PDCD4/GATA3/SERPINE1/GATA2/PDPK1/NFE2L2 6 GO:0009755 hormone-mediated signaling pathway 13/770 190/18722 0.0505612184272583 0.268599734992567 DAB2/ESRRG/PGRMC2/LGR4/GHR/UBR5/LATS2/PPARD/EGLN2/CALR/PRLR/DNAJA1/UBA5 13 GO:0030041 actin filament polymerization 13/770 190/18722 0.0505612184272583 0.268599734992567 RASA1/SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/ARHGAP18/IQGAP2 13 GO:0002444 myeloid leukocyte mediated immunity 8/770 99/18722 0.0512043181884683 0.271437359077806 HMOX1/DHX36/GATA2/SERPINB9/PDPK1/PI4K2A/STXBP3/SNAP23 8 GO:0010717 regulation of epithelial to mesenchymal transition 8/770 99/18722 0.0512043181884683 0.271437359077806 DAB2/GATA3/ZNF703/BCL9L/PHLDB2/ZNF750/CTNNB1/FERMT2 8 GO:0046889 positive regulation of lipid biosynthetic process 7/770 82/18722 0.0516584714282203 0.273553839667186 CGA/ANXA1/ABCG1/LDLR/RDH10/SORBS1/ADM 7 GO:0001101 response to acid chemical 10/770 135/18722 0.0520313502212541 0.275011844864723 CEBPB/SLC38A9/AKR1B1/CPEB4/SH3BP4/RRAGC/UBR1/SOCS1/KRT8/CDO1 10 GO:0030301 cholesterol transport 9/770 117/18722 0.0520879177633975 0.275011844864723 ARL8B/NFKBIA/FURIN/SYT7/ABCG1/VPS4B/LDLR/LRP1/OSBP 9 GO:0002685 regulation of leukocyte migration 14/770 210/18722 0.0521545641977048 0.275011844864723 ANXA1/PGF/ST3GAL4/HMOX1/APP/SERPINE1/MPP1/CD200/WASL/MTUS1/AKIRIN1/DDT/CALR/MIF 14 GO:0050866 negative regulation of cell activation 14/770 210/18722 0.0521545641977048 0.275011844864723 ANXA1/HMOX1/CEBPB/ARG2/GLI3/CD200/SOCS1/CD274/ID2/TNFRSF21/DLG5/DUSP3/C1QTNF1/LDLR 14 GO:0045926 negative regulation of growth 16/770 249/18722 0.0525508195665271 0.276685270566809 CGA/GDF15/SEMA6A/SPAG9/BCL2/SH3BP4/SEMA7A/BTG1/SERTAD3/DIP2B/PPARD/DDX3X/RBBP7/HSPA1B/NRP1/GPC3 16 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 3/770 21/18722 0.0531096482012247 0.276685270566809 COX6C/COX4I1/COX6A1 3 GO:0007350 blastoderm segmentation 3/770 21/18722 0.0531096482012247 0.276685270566809 TBX3/BASP1/NRP1 3 GO:0030449 regulation of complement activation 3/770 21/18722 0.0531096482012247 0.276685270566809 CD55/CD46/CD59 3 GO:0032482 Rab protein signal transduction 3/770 21/18722 0.0531096482012247 0.276685270566809 RAB9A/RAB21/RAB4B 3 GO:0044766 multi-organism transport 3/770 21/18722 0.0531096482012247 0.276685270566809 CTSL/KPNA6/RAB7A 3 GO:0048485 sympathetic nervous system development 3/770 21/18722 0.0531096482012247 0.276685270566809 GATA3/CTNNB1/NRP1 3 GO:1902307 positive regulation of sodium ion transmembrane transport 3/770 21/18722 0.0531096482012247 0.276685270566809 ARF1/SLC9A1/ACTN4 3 GO:1902579 multi-organism localization 3/770 21/18722 0.0531096482012247 0.276685270566809 CTSL/KPNA6/RAB7A 3 GO:2000178 negative regulation of neural precursor cell proliferation 3/770 21/18722 0.0531096482012247 0.276685270566809 SPINT1/GATA2/SPINT2 3 GO:0045055 regulated exocytosis 15/770 230/18722 0.0533113124394748 0.276685270566809 HMOX1/SCIN/ARL8B/RAP1B/GATA2/SYT7/NAPA/PDPK1/ARF1/PI4K2A/SYNJ1/RAB5A/STXBP3/SNAP23/RAB11FIP1 15 GO:0008360 regulation of cell shape 11/770 154/18722 0.0533433153052387 0.276685270566809 ANXA1/RHOBTB1/RASA1/EZR/EPB41L3/FGD6/MYO10/CDC42EP4/ARHGAP18/RHOBTB3/FERMT2 11 GO:0050770 regulation of axonogenesis 11/770 154/18722 0.0533433153052387 0.276685270566809 SEMA6A/EIF4G2/RAB11A/GOLGA4/SEMA7A/DIP2B/LRP1/MAP3K13/NRP1/PAFAH1B1/CDKL5 11 GO:0050863 regulation of T cell activation 20/770 329/18722 0.0534394872730623 0.276685270566809 ANXA1/PRKCZ/TFRC/CEBPB/GATA3/CD55/ARG2/PNP/HES1/GLI3/SOCS1/CD274/TNFRSF21/DLG5/CD46/DUSP3/CTNNB1/PRELID1/SOD1/HSPD1 20 GO:0014015 positive regulation of gliogenesis 6/770 66/18722 0.0536807471732082 0.276685270566809 EGFR/SPINT1/HES1/ID2/SYNJ1/RHEB 6 GO:0042446 hormone biosynthetic process 6/770 66/18722 0.0536807471732082 0.276685270566809 CYP19A1/HSD17B1/CYP11A1/FDX1/AKR1B1/ADM 6 GO:0050922 negative regulation of chemotaxis 6/770 66/18722 0.0536807471732082 0.276685270566809 SEMA6A/SEMA7A/DUSP3/DDT/NRP1/MIF 6 GO:1905953 negative regulation of lipid localization 6/770 66/18722 0.0536807471732082 0.276685270566809 ABHD5/NFKBIA/ABCG1/PPARD/IRS2/PNPLA2 6 GO:2000573 positive regulation of DNA biosynthetic process 6/770 66/18722 0.0536807471732082 0.276685270566809 NEK7/PKIB/TNKS2/CTNNB1/MAP3K4/HSP90AA1 6 GO:0002448 mast cell mediated immunity 5/770 50/18722 0.053748176078441 0.276685270566809 HMOX1/GATA2/SERPINB9/PDPK1/SNAP23 5 GO:0046638 positive regulation of alpha-beta T cell differentiation 5/770 50/18722 0.053748176078441 0.276685270566809 ANXA1/PRKCZ/PNP/GLI3/SOCS1 5 GO:2000677 regulation of transcription regulatory region DNA binding 5/770 50/18722 0.053748176078441 0.276685270566809 GATA3/DDIT3/MSX2/GTF2B/CTNNB1 5 GO:0046545 development of primary female sexual characteristics 8/770 100/18722 0.053749015032846 0.276685270566809 CYP19A1/ARID5B/NUPR1/CEBPB/BCL2/HSPA5/EIF2B2/SOD1 8 GO:0043624 cellular protein complex disassembly 10/770 136/18722 0.0541948675034677 0.277703900300165 SCIN/ETF1/CCSAP/ATXN7/NAPA/VPS4B/SYNJ1/CAMSAP2/HSPA8/TAOK1 10 GO:0010664 negative regulation of striated muscle cell apoptotic process 4/770 35/18722 0.0542255458543167 0.277703900300165 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0034331 cell junction maintenance 4/770 35/18722 0.0542255458543167 0.277703900300165 MTSS1/ERC1/OPHN1/FERMT2 4 GO:0045454 cell redox homeostasis 4/770 35/18722 0.0542255458543167 0.277703900300165 DDIT3/EGLN2/PRDX6/NFE2L2 4 GO:0090181 regulation of cholesterol metabolic process 4/770 35/18722 0.0542255458543167 0.277703900300165 ABCG1/ACADVL/LDLR/SOD1 4 GO:0051101 regulation of DNA binding 9/770 118/18722 0.0544337299207796 0.27848385646329 HMOX1/GATA3/HES1/DDIT3/NFKBIA/MSX2/EDF1/GTF2B/CTNNB1 9 GO:0070371 ERK1 and ERK2 cascade 20/770 330/18722 0.0547988415457995 0.280064233254071 PRKCZ/SEMA6A/EGFR/EZR/FBLN1/ATF3/APP/DUSP9/BRAF/SEMA7A/RAP1B/P2RY6/DUSP3/DDT/LRP1/GAREM1/NRP1/MIF/ERRFI1/FERMT2 20 GO:0034504 protein localization to nucleus 18/770 290/18722 0.054865682543221 0.280118541099252 TFRC/PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/LIMK2/LATS2/SKP1/MDM2/LMNA/PPP1R10/CALR/DNAJB6/TNPO1/TOR1AIP2/FERMT2 18 GO:0010970 transport along microtubule 11/770 155/18722 0.0553926254805888 0.282519398945521 PRKCZ/HSPB1/APP/ARL8B/CLN3/RAB1A/RAB21/ARMCX3/PAFAH1B1/HSPA8/SOD1 11 GO:0019216 regulation of lipid metabolic process 20/770 331/18722 0.0561824240670473 0.28625462078333 CGA/ANXA1/VAV3/ABHD5/SAMD8/ID2/EDF1/ABCG1/PPARD/ARF1/IRS2/ACADVL/LDLR/PNPLA2/RDH10/ORMDL1/INSIG1/SORBS1/ADM/SOD1 20 GO:0000086 G2/M transition of mitotic cell cycle 10/770 137/18722 0.0564169671254391 0.286863007332717 NABP1/RAB11A/APP/FOXO4/CDK2/VPS4B/BRD4/PBX1/USP47/TAOK1 10 GO:0050684 regulation of mRNA processing 10/770 137/18722 0.0564169671254391 0.286863007332717 PAPOLA/MBNL3/SAP18/DHX36/RBM8A/RBM42/SUPT6H/IWS1/PRDX6/HSPA8 10 GO:0010594 regulation of endothelial cell migration 15/770 232/18722 0.0566349107439943 0.287677635308179 ANXA1/HSPB1/HMOX1/PIK3C2A/GATA3/PLPP3/HDAC5/GATA2/JUP/PDPK1/CALR/NRP1/SERPINF1/PDCD6/NFE2L2 15 GO:0006879 cellular iron ion homeostasis 6/770 67/18722 0.0570070629040136 0.288685156962093 SLC40A1/TFRC/HMOX1/ATP6V1G1/ATP6V0D1/SOD1 6 GO:0046635 positive regulation of alpha-beta T cell activation 6/770 67/18722 0.0570070629040136 0.288685156962093 ANXA1/PRKCZ/CD55/PNP/GLI3/SOCS1 6 GO:0048814 regulation of dendrite morphogenesis 6/770 67/18722 0.0570070629040136 0.288685156962093 NEDD4L/DHX36/RAB21/CUX1/PAFAH1B1/CDKL5 6 GO:0002683 negative regulation of immune system process 25/770 434/18722 0.0572664007858937 0.289704035650872 ANXA1/HMOX1/CEBPB/CD55/ARG2/EZR/GLI3/CD200/SOCS1/CD274/WASL/GATA2/ID2/FURIN/SERPINB9/TNFRSF21/DLG5/CD46/DUSP3/CTNNB1/DDT/LDLR/PSMB4/CD59/MIF 25 GO:0043583 ear development 14/770 213/18722 0.0573649011762299 0.289908014767904 GATA3/TFAP2A/HES1/BCL2/GLI3/GATA2/CEBPA/TRIP11/DLX5/MYO6/RDH10/INSIG1/PAFAH1B1/SOD1 14 GO:0046631 alpha-beta T cell activation 11/770 156/18722 0.0574937161878349 0.289951180994072 ANXA1/PRKCZ/GATA3/CD55/CTSL/ARG2/PNP/BCL2/GLI3/SOCS1/CD274 11 GO:0009948 anterior/posterior axis specification 5/770 51/18722 0.0576643829751406 0.289951180994072 TBX3/BASP1/DDIT3/CTNNB1/GPC3 5 GO:0010656 negative regulation of muscle cell apoptotic process 5/770 51/18722 0.0576643829751406 0.289951180994072 NUPR1/HMOX1/PDPK1/PPP1R10/NFE2L2 5 GO:0032873 negative regulation of stress-activated MAPK cascade 5/770 51/18722 0.0576643829751406 0.289951180994072 PDCD4/EZR/DUSP3/PAFAH1B1/DNAJA1 5 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 5/770 51/18722 0.0576643829751406 0.289951180994072 PDCD4/EZR/DUSP3/PAFAH1B1/DNAJA1 5 GO:1901654 response to ketone 13/770 194/18722 0.0578188633228348 0.290434874937183 EGFR/FDX1/AKR1B1/GNAI1/FBXO32/P2RY6/XRN1/CALR/SERPINF1/ERRFI1/TGFBR3/USP8/CLDN4 13 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 10/770 138/18722 0.0586980501684443 0.292027714845222 ARRDC3/PTTG1IP/VCP/HSPA5/SKP1/DDX3X/TANK/UBQLN1/PDCD6/COMMD1 10 GO:0035710 CD4-positive, alpha-beta T cell activation 8/770 102/18722 0.0590775897133082 0.292027714845222 ANXA1/PRKCZ/GATA3/CD55/CTSL/ARG2/SOCS1/CD274 8 GO:0042092 type 2 immune response 4/770 36/18722 0.059101174383281 0.292027714845222 ANXA1/PRKCZ/GATA3/ARG2 4 GO:0070873 regulation of glycogen metabolic process 4/770 36/18722 0.059101174383281 0.292027714845222 PHLDA2/IRS2/SORBS1/PPP1CB 4 GO:0044242 cellular lipid catabolic process 14/770 214/18722 0.0591776277746762 0.292027714845222 ABHD5/ABHD3/NEU1/PNPLA8/PPARD/IRS2/FUCA1/ACADVL/GLA/LDLR/AIG1/LRP1/PNPLA2/PRDX6 14 GO:0030098 lymphocyte differentiation 22/770 374/18722 0.0594533625681062 0.292027714845222 ANXA1/PRKCZ/GATA3/CTSL/PNP/BCL2/GLI3/HDAC5/SOCS1/HECTD1/ID2/DNAJB9/NFIL3/SLC25A5/TPD52/CD46/CTNNB1/FNIP1/PRELID1/KDELR1/PBX1/SOD1 22 GO:1990845 adaptive thermogenesis 11/770 157/18722 0.0596469389248358 0.292027714845222 GADD45G/ESRRG/CEBPB/ARRDC3/DDIT3/EPAS1/LGR4/GNAS/SLC25A5/PRLR/RHEB 11 GO:0016137 glycoside metabolic process 3/770 22/18722 0.0596803921426817 0.292027714845222 AKR1B1/FUCA1/GLA 3 GO:0034629 cellular protein-containing complex localization 3/770 22/18722 0.0596803921426817 0.292027714845222 EZR/AKAP9/WASL 3 GO:0035809 regulation of urine volume 3/770 22/18722 0.0596803921426817 0.292027714845222 AKR1B1/MLLT6/ADM 3 GO:0048169 regulation of long-term neuronal synaptic plasticity 3/770 22/18722 0.0596803921426817 0.292027714845222 RAB11A/APP/RAB5A 3 GO:0060563 neuroepithelial cell differentiation 3/770 22/18722 0.0596803921426817 0.292027714845222 CEBPB/SERPINE1/HES1 3 GO:0099563 modification of synaptic structure 3/770 22/18722 0.0596803921426817 0.292027714845222 CLN3/CHMP2B/STAU1 3 GO:1900120 regulation of receptor binding 3/770 22/18722 0.0596803921426817 0.292027714845222 PHLDA2/GREM2/NRP1 3 GO:0032922 circadian regulation of gene expression 6/770 68/18722 0.0604544174034293 0.292027714845222 TOP1/LGR4/ID2/BHLHE40/CSNK1E/PPP1CB 6 GO:0046637 regulation of alpha-beta T cell differentiation 6/770 68/18722 0.0604544174034293 0.292027714845222 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1 6 GO:0010507 negative regulation of autophagy 7/770 85/18722 0.0605046295925712 0.292027714845222 NUPR1/HMOX1/EIF4G2/BCL2/GOLGA2/FEZ2/CHMP4B 7 GO:0045785 positive regulation of cell adhesion 25/770 437/18722 0.0610384347118725 0.292027714845222 ANXA1/PRKCZ/ST3GAL4/TFRC/GATA3/CD55/VAV3/PNP/HES1/TGM2/GLI3/PLPP3/SOCS1/CD274/MYO10/FMN1/JUP/P4HB/ADGRG1/CD46/CALR/UTRN/NRP1/FERMT2/HSPD1 25 GO:0016579 protein deubiquitination 10/770 139/18722 0.0610384844396004 0.292027714845222 OTUB2/VCP/ATXN7/USP43/TANK/UBXN1/USP8/USP16/PSMD14/USP47 10 GO:0000050 urea cycle 2/770 10/18722 0.0610662008566568 0.292027714845222 ARG2/CEBPA 2 GO:0002002 regulation of angiotensin levels in blood 2/770 10/18722 0.0610662008566568 0.292027714845222 MME/ENPEP 2 GO:0002003 angiotensin maturation 2/770 10/18722 0.0610662008566568 0.292027714845222 MME/ENPEP 2 GO:0010172 embryonic body morphogenesis 2/770 10/18722 0.0610662008566568 0.292027714845222 GREM2/PHLDB2 2 GO:0014041 regulation of neuron maturation 2/770 10/18722 0.0610662008566568 0.292027714845222 BCL2/MAP3K13 2 GO:0015911 long-chain fatty acid import across plasma membrane 2/770 10/18722 0.0610662008566568 0.292027714845222 SLC2A1/IRS2 2 GO:0016139 glycoside catabolic process 2/770 10/18722 0.0610662008566568 0.292027714845222 FUCA1/GLA 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/770 10/18722 0.0610662008566568 0.292027714845222 P4HB/EGLN2 2 GO:0032025 response to cobalt ion 2/770 10/18722 0.0610662008566568 0.292027714845222 ATF1/SERPINF1 2 GO:0032275 luteinizing hormone secretion 2/770 10/18722 0.0610662008566568 0.292027714845222 CGA/TBX3 2 GO:0035376 sterol import 2/770 10/18722 0.0610662008566568 0.292027714845222 LDLR/LRP1 2 GO:0035520 monoubiquitinated protein deubiquitination 2/770 10/18722 0.0610662008566568 0.292027714845222 USP16/USP47 2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 2/770 10/18722 0.0610662008566568 0.292027714845222 GDF15/GATA3 2 GO:0048262 determination of dorsal/ventral asymmetry 2/770 10/18722 0.0610662008566568 0.292027714845222 DDIT3/CTNNB1 2 GO:0051409 response to nitrosative stress 2/770 10/18722 0.0610662008566568 0.292027714845222 DDIT3/DNAJA1 2 GO:0051660 establishment of centrosome localization 2/770 10/18722 0.0610662008566568 0.292027714845222 EZR/PAFAH1B1 2 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 2/770 10/18722 0.0610662008566568 0.292027714845222 CTNNB1/SERPINF1 2 GO:0061085 regulation of histone H3-K27 methylation 2/770 10/18722 0.0610662008566568 0.292027714845222 GATA3/SUPT6H 2 GO:0070508 cholesterol import 2/770 10/18722 0.0610662008566568 0.292027714845222 LDLR/LRP1 2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 2/770 10/18722 0.0610662008566568 0.292027714845222 ERLEC1/INSIG1 2 GO:0072178 nephric duct morphogenesis 2/770 10/18722 0.0610662008566568 0.292027714845222 GATA3/GPC3 2 GO:0097084 vascular associated smooth muscle cell development 2/770 10/18722 0.0610662008566568 0.292027714845222 HES1/ADM 2 GO:0097278 complement-dependent cytotoxicity 2/770 10/18722 0.0610662008566568 0.292027714845222 CD55/CD59 2 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 2/770 10/18722 0.0610662008566568 0.292027714845222 RAB11A/GRIP1 2 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/770 10/18722 0.0610662008566568 0.292027714845222 PMAIP1/DDIT3 2 GO:1902946 protein localization to early endosome 2/770 10/18722 0.0610662008566568 0.292027714845222 EZR/NRP1 2 GO:1903867 extraembryonic membrane development 2/770 10/18722 0.0610662008566568 0.292027714845222 DNAJB6/MAP3K4 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/770 10/18722 0.0610662008566568 0.292027714845222 LDLR/LRP1 2 GO:1905456 regulation of lymphoid progenitor cell differentiation 2/770 10/18722 0.0610662008566568 0.292027714845222 HES1/FNIP1 2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 2/770 10/18722 0.0610662008566568 0.292027714845222 PDPK1/EIF4A3 2 GO:2000288 positive regulation of myoblast proliferation 2/770 10/18722 0.0610662008566568 0.292027714845222 PPARD/MALAT1 2 GO:0045664 regulation of neuron differentiation 13/770 196/18722 0.0616985141498611 0.293676081584929 APP/SPAG9/HES1/BCL2/GLI3/GATA2/ID2/MIB1/CALR/MAP3K13/CSNK1E/PBX1/HMG20B 13 GO:0010718 positive regulation of epithelial to mesenchymal transition 5/770 52/18722 0.0617397708337807 0.293676081584929 DAB2/ZNF703/BCL9L/CTNNB1/FERMT2 5 GO:0014013 regulation of gliogenesis 8/770 103/18722 0.0618623357898744 0.293676081584929 EGFR/SPINT1/HES1/ID2/CTNNB1/LDLR/SYNJ1/RHEB 8 GO:0050773 regulation of dendrite development 8/770 103/18722 0.0618623357898744 0.293676081584929 NEDD4L/DHX36/RAB21/CAMSAP2/CUX1/PAFAH1B1/CDKL5/TMEM106B 8 GO:0090277 positive regulation of peptide hormone secretion 8/770 103/18722 0.0618623357898744 0.293676081584929 EGFR/SERP1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 8 GO:0001838 embryonic epithelial tube formation 9/770 121/18722 0.0618788600439739 0.293676081584929 GATA3/SPINT1/HECTD1/MIB1/DVL3/SPINT2/BRD2/CTNNB1/ADM 9 GO:0042752 regulation of circadian rhythm 9/770 121/18722 0.0618788600439739 0.293676081584929 SIAH2/ID2/OPN3/BHLHE40/NR2F6/DDB1/CSNK1E/PHLPP1/PPP1CB 9 GO:0045930 negative regulation of mitotic cell cycle 15/770 235/18722 0.0618823772153674 0.293676081584929 BTG3/CDKN1C/EGFR/NABP1/OVOL1/BCL2/BTG1/FOXO4/MDM2/CDK2/PPP1R10/CTNNB1/GIGYF2/USP47/TAOK1 15 GO:0006368 transcription elongation from RNA polymerase II promoter 6/770 69/18722 0.0640229747200687 0.300393039218456 HEXIM1/ADRM1/CTNNB1/SUPT6H/SERTAD1/BRD4 6 GO:0060193 positive regulation of lipase activity 6/770 69/18722 0.0640229747200687 0.300393039218456 PRKCZ/EGFR/ABHD5/ARF4/P2RY6/PDPK1 6 GO:1901224 positive regulation of NIK/NF-kappaB signaling 6/770 69/18722 0.0640229747200687 0.300393039218456 PDCD4/EGFR/APP/DDX3X/CALR/ACTN4 6 GO:0006109 regulation of carbohydrate metabolic process 12/770 178/18722 0.0641411462459827 0.300393039218456 NUPR1/PMAIP1/PHLDA2/APP/AP2A1/P2RY6/DDB1/IRS2/C1QTNF1/SORBS1/SLC35B4/PPP1CB 12 GO:0035725 sodium ion transmembrane transport 12/770 178/18722 0.0641411462459827 0.300393039218456 FXYD3/SLC3A2/NEDD4L/SLC6A8/KLHL24/ARF1/SLC9A1/UTRN/SLC20A1/STOM/COMMD1/ACTN4 12 GO:0050890 cognition 18/770 296/18722 0.0641881384564662 0.300393039218456 PRKCZ/ST3GAL4/SGK1/EGFR/CEBPB/APP/MME/PAIP2/TUSC3/ARF4/CLN3/CLN8/CHMP2B/LDLR/SYNJ1/EIF4A3/SERPINF1/PAFAH1B1 18 GO:0003161 cardiac conduction system development 4/770 37/18722 0.0642020041677013 0.300393039218456 TBX3/HOPX/MSX2/ID2 4 GO:0006623 protein targeting to vacuole 4/770 37/18722 0.0642020041677013 0.300393039218456 ZFYVE16/VPS37A/RAB7A/HSPA8 4 GO:0031112 positive regulation of microtubule polymerization or depolymerization 4/770 37/18722 0.0642020041677013 0.300393039218456 CLIP1/AKAP9/NUMA1/HSPA1B 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/770 37/18722 0.0642020041677013 0.300393039218456 AP2A1/IRS2/SORBS1/PPP1CB 4 GO:0033120 positive regulation of RNA splicing 4/770 37/18722 0.0642020041677013 0.300393039218456 ERN1/SRSF5/PRDX6/HSPA8 4 GO:0033363 secretory granule organization 4/770 37/18722 0.0642020041677013 0.300393039218456 ABCG1/TBC1D20/OSBP/PAFAH1B1 4 GO:0042401 cellular biogenic amine biosynthetic process 4/770 37/18722 0.0642020041677013 0.300393039218456 GATA3/SAT1/SMS/AZIN1 4 GO:0043403 skeletal muscle tissue regeneration 4/770 37/18722 0.0642020041677013 0.300393039218456 ANXA1/HOPX/PPARD/AKIRIN1 4 GO:0045616 regulation of keratinocyte differentiation 4/770 37/18722 0.0642020041677013 0.300393039218456 NCOA3/GRHL1/NUMA1/ERRFI1 4 GO:0010631 epithelial cell migration 21/770 357/18722 0.0643793807850451 0.300929098767811 ANXA1/HSPB1/S100P/HMOX1/PIK3C2A/GATA3/RAB11A/EPHB4/PLPP3/HDAC5/GATA2/JUP/PPARD/PDPK1/LGALS8/CALR/KANK1/NRP1/SERPINF1/PDCD6/NFE2L2 21 GO:0031109 microtubule polymerization or depolymerization 9/770 122/18722 0.0644977478394586 0.300929098767811 CLIP1/GOLGA2/AKAP9/CCSAP/ATXN7/NUMA1/HSPA1B/CAMSAP2/TAOK1 9 GO:0050868 negative regulation of T cell activation 9/770 122/18722 0.0644977478394586 0.300929098767811 ANXA1/CEBPB/ARG2/GLI3/SOCS1/CD274/TNFRSF21/DLG5/DUSP3 9 GO:0048661 positive regulation of smooth muscle cell proliferation 8/770 104/18722 0.0647278577370969 0.301720219928862 HMOX1/EGFR/AKR1B1/TGM2/ERN1/P2RY6/ID2/MDM2 8 GO:0007596 blood coagulation 14/770 217/18722 0.0648472016381481 0.301994024077469 HSPB1/ST3GAL4/SERPINB2/VAV3/FBLN1/SERPINE1/GNA12/AK3/GNAS/F5/C1QTNF1/CD59/STXBP3/NFE2L2 14 GO:0007179 transforming growth factor beta receptor signaling pathway 13/770 198/18722 0.0657482900565189 0.305079384231224 GDF15/DAB2/CDKN1C/PEG10/ZNF703/BCL9L/HSPA5/FURIN/LATS2/PDPK1/SNX6/TGFBR3/FERMT2 13 GO:0048167 regulation of synaptic plasticity 13/770 198/18722 0.0657482900565189 0.305079384231224 SQSTM1/PRKCZ/RAB11A/APP/MME/ERC1/PAIP2/SYT7/CLN3/ARF1/SYAP1/RAB5A/STAU1 13 GO:0008347 glial cell migration 5/770 53/18722 0.0659738703468871 0.305079384231224 GLI3/ADGRG1/CTNNB1/LRP1/PAFAH1B1 5 GO:0032784 regulation of DNA-templated transcription, elongation 5/770 53/18722 0.0659738703468871 0.305079384231224 HEXIM1/CTNNB1/SUPT6H/BRD4/ALYREF 5 GO:0006622 protein targeting to lysosome 3/770 23/18722 0.0666117539722198 0.305079384231224 ZFYVE16/RAB7A/HSPA8 3 GO:0018279 protein N-linked glycosylation via asparagine 3/770 23/18722 0.0666117539722198 0.305079384231224 TUSC3/RPN2/DDOST 3 GO:0021895 cerebral cortex neuron differentiation 3/770 23/18722 0.0666117539722198 0.305079384231224 C21orf91/OPHN1/PAFAH1B1 3 GO:0030194 positive regulation of blood coagulation 3/770 23/18722 0.0666117539722198 0.305079384231224 ST3GAL4/SERPINE1/NFE2L2 3 GO:0030539 male genitalia development 3/770 23/18722 0.0666117539722198 0.305079384231224 TBX3/LGR4/CTNNB1 3 GO:0035162 embryonic hemopoiesis 3/770 23/18722 0.0666117539722198 0.305079384231224 GATA3/GATA2/PBX1 3 GO:0035994 response to muscle stretch 3/770 23/18722 0.0666117539722198 0.305079384231224 NFKBIA/CTNNB1/SLC9A1 3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 3/770 23/18722 0.0666117539722198 0.305079384231224 VPS4B/TSG101/VPS37A 3 GO:0051131 chaperone-mediated protein complex assembly 3/770 23/18722 0.0666117539722198 0.305079384231224 HOPX/HSP90AA1/HSPD1 3 GO:0060396 growth hormone receptor signaling pathway 3/770 23/18722 0.0666117539722198 0.305079384231224 GDF15/GHR/LEPROT 3 GO:0071636 positive regulation of transforming growth factor beta production 3/770 23/18722 0.0666117539722198 0.305079384231224 CD200/FURIN/CD46 3 GO:0090208 positive regulation of triglyceride metabolic process 3/770 23/18722 0.0666117539722198 0.305079384231224 ABHD5/LDLR/PNPLA2 3 GO:1900048 positive regulation of hemostasis 3/770 23/18722 0.0666117539722198 0.305079384231224 ST3GAL4/SERPINE1/NFE2L2 3 GO:1903306 negative regulation of regulated secretory pathway 3/770 23/18722 0.0666117539722198 0.305079384231224 HMOX1/RAP1B/STXBP3 3 GO:0016101 diterpenoid metabolic process 7/770 87/18722 0.0668870985230759 0.305498086104938 EGFR/AKR1B1/RDH13/PPARD/LRP1/PNPLA2/RDH10 7 GO:0019915 lipid storage 7/770 87/18722 0.0668870985230759 0.305498086104938 ABHD5/NFKBIA/MEST/ABCG1/PLIN2/PPARD/PNPLA2 7 GO:2000177 regulation of neural precursor cell proliferation 7/770 87/18722 0.0668870985230759 0.305498086104938 SPINT1/GLI3/GATA2/ID2/ADGRG1/SPINT2/CTNNB1 7 GO:0070661 leukocyte proliferation 19/770 318/18722 0.0671166664619595 0.306265887344271 ANXA1/TFRC/CEBPB/CD55/VAV3/ARG2/PNP/HES1/BCL2/CD274/TNFRSF21/DLG5/CD46/IRS2/CTNNB1/TBK1/MIF/HSPD1/CCND3 19 GO:0003231 cardiac ventricle development 9/770 123/18722 0.0671857488792648 0.306300628239137 TBX3/GATA3/DSP/HES1/HECTD1/MDM2/TRIP11/PPP1R13L/TGFBR3 9 GO:0031349 positive regulation of defense response 17/770 278/18722 0.0677439425536697 0.308563131393909 NUPR1/PDCD4/EGFR/CEBPB/HEXIM1/APP/SERPINE1/TGM2/NFKBIA/CEBPA/NEAT1/DDT/AKIRIN2/LDLR/TBK1/HSP90AA1/HSPD1 17 GO:0042098 T cell proliferation 13/770 199/18722 0.0678375657814012 0.308707388391527 ANXA1/TFRC/CEBPB/CD55/ARG2/PNP/HES1/CD274/TNFRSF21/DLG5/CD46/CTNNB1/CCND3 13 GO:0048660 regulation of smooth muscle cell proliferation 12/770 180/18722 0.0685360803376311 0.31160154044016 HMOX1/PDCD4/EGFR/AKR1B1/GNA12/TGM2/ERN1/P2RY6/ID2/PPARD/MDM2/CTNNB1 12 GO:0003205 cardiac chamber development 11/770 161/18722 0.0687872857495304 0.312458564165825 TBX3/GATA3/DSP/HES1/HECTD1/MDM2/TRIP11/PPP1R13L/NRP1/TGFBR3/ADAMTS6 11 GO:0090132 epithelium migration 21/770 360/18722 0.0689513546213515 0.312918579306188 ANXA1/HSPB1/S100P/HMOX1/PIK3C2A/GATA3/RAB11A/EPHB4/PLPP3/HDAC5/GATA2/JUP/PPARD/PDPK1/LGALS8/CALR/KANK1/NRP1/SERPINF1/PDCD6/NFE2L2 21 GO:0009309 amine biosynthetic process 4/770 38/18722 0.0695253453969983 0.313729756671832 GATA3/SAT1/SMS/AZIN1 4 GO:0042491 inner ear auditory receptor cell differentiation 4/770 38/18722 0.0695253453969983 0.313729756671832 HES1/MYO6/PAFAH1B1/SOD1 4 GO:0046329 negative regulation of JNK cascade 4/770 38/18722 0.0695253453969983 0.313729756671832 PDCD4/DUSP3/PAFAH1B1/DNAJA1 4 GO:0048246 macrophage chemotaxis 4/770 38/18722 0.0695253453969983 0.313729756671832 MTUS1/AKIRIN1/DDT/MIF 4 GO:0048713 regulation of oligodendrocyte differentiation 4/770 38/18722 0.0695253453969983 0.313729756671832 HES1/TNFRSF21/CTNNB1/RHEB 4 GO:0071392 cellular response to estradiol stimulus 4/770 38/18722 0.0695253453969983 0.313729756671832 EGFR/NCOA3/ZNF703/LCOR 4 GO:0030099 myeloid cell differentiation 22/770 381/18722 0.0695708170022825 0.313729756671832 TFRC/CSF3R/CEBPB/GATA3/ALAS1/SCIN/APP/EPAS1/EIF2AK1/NFKBIA/BPGM/GATA2/ID2/SLC25A5/CEBPA/TET2/CTNNB1/HSPA1B/GPC3/PAFAH1B1/TGFBR3/UBA5 22 GO:0031110 regulation of microtubule polymerization or depolymerization 7/770 88/18722 0.0702245331033635 0.315631939780512 CLIP1/AKAP9/ATXN7/NUMA1/HSPA1B/CAMSAP2/TAOK1 7 GO:0060350 endochondral bone morphogenesis 5/770 54/18722 0.0703659465237871 0.315631939780512 ANXA6/PHOSPHO1/GHR/TRIP11/DLX5 5 GO:0071496 cellular response to external stimulus 19/770 320/18722 0.0704344890183018 0.315631939780512 HMOX1/PMAIP1/SLC2A1/EGFR/MAP1LC3B/GABARAPL1/ATF3/BCL2/CPEB4/MAP1LC3A/RRAGC/TMEM150C/HSPA5/MDM2/FNIP1/SLC9A1/GABARAPL2/HSPA8/NFE2L2 19 GO:0002793 positive regulation of peptide secretion 8/770 106/18722 0.0707022446763338 0.315631939780512 EGFR/SERP1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 8 GO:0042116 macrophage activation 8/770 106/18722 0.0707022446763338 0.315631939780512 APP/CD200/DYSF/JUND/CEBPA/LDLR/MIF/HSPD1 8 GO:0006479 protein methylation 12/770 181/18722 0.0708052362007879 0.315631939780512 GATA3/ETF1/BTG1/KMT2C/TET2/MLLT6/LMNA/CTNNB1/PCMTD1/SUPT6H/IWS1/BRD4 12 GO:0008213 protein alkylation 12/770 181/18722 0.0708052362007879 0.315631939780512 GATA3/ETF1/BTG1/KMT2C/TET2/MLLT6/LMNA/CTNNB1/PCMTD1/SUPT6H/IWS1/BRD4 12 GO:0002064 epithelial cell development 14/770 220/18722 0.0708685088203488 0.315631939780512 EZR/AKR1B1/SDC1/DACT2/RAP1B/YIPF6/TBC1D20/PDPK1/RAPGEF1/SPINT2/RAP2C/PAFAH1B1/RHEB/SOD1 14 GO:0006865 amino acid transport 10/770 143/18722 0.070999900385913 0.315631939780512 KMO/SLC43A2/SLC3A2/SLC38A1/SLC38A9/SERINC5/SLC7A5/CLN3/CLN8/SLC7A6 10 GO:0031023 microtubule organizing center organization 10/770 143/18722 0.070999900385913 0.315631939780512 GOLGA2/CHMP2B/UVRAG/CDK2/CTNNB1/VPS4B/CEP152/CHMP4B/PAFAH1B1/CHMP2A 10 GO:0021953 central nervous system neuron differentiation 11/770 162/18722 0.0712055416645392 0.315631939780512 HES1/GLI3/C21orf91/GATA2/OPHN1/CLN8/SCYL1/GIGYF2/NRP1/HSP90AA1/PAFAH1B1 11 GO:0032886 regulation of microtubule-based process 15/770 240/18722 0.0713416143013706 0.315631939780512 CLIP1/GNAI1/AKAP9/CCSAP/ATXN7/PHLDB2/CHMP2B/NUMA1/VPS4B/HSPA1B/CAMSAP2/CHMP4B/PAFAH1B1/TAOK1/CHMP2A 15 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 2/770 11/18722 0.072652987141932 0.315631939780512 CD55/CD46 2 GO:0003263 cardioblast proliferation 2/770 11/18722 0.072652987141932 0.315631939780512 HES1/CTNNB1 2 GO:0003264 regulation of cardioblast proliferation 2/770 11/18722 0.072652987141932 0.315631939780512 HES1/CTNNB1 2 GO:0007042 lysosomal lumen acidification 2/770 11/18722 0.072652987141932 0.315631939780512 CLN3/TMEM106B 2 GO:0010887 negative regulation of cholesterol storage 2/770 11/18722 0.072652987141932 0.315631939780512 ABCG1/PPARD 2 GO:0033234 negative regulation of protein sumoylation 2/770 11/18722 0.072652987141932 0.315631939780512 CTNNB1/HMG20B 2 GO:0033625 positive regulation of integrin activation 2/770 11/18722 0.072652987141932 0.315631939780512 RAP1B/FERMT2 2 GO:0035581 sequestering of extracellular ligand from receptor 2/770 11/18722 0.072652987141932 0.315631939780512 GREM2/CD46 2 GO:0043589 skin morphogenesis 2/770 11/18722 0.072652987141932 0.315631939780512 ITGB4/ERRFI1 2 GO:0045628 regulation of T-helper 2 cell differentiation 2/770 11/18722 0.072652987141932 0.315631939780512 ANXA1/PRKCZ 2 GO:0045654 positive regulation of megakaryocyte differentiation 2/770 11/18722 0.072652987141932 0.315631939780512 SCIN/GATA2 2 GO:0046501 protoporphyrinogen IX metabolic process 2/770 11/18722 0.072652987141932 0.315631939780512 ALAS1/EIF2AK1 2 GO:0048715 negative regulation of oligodendrocyte differentiation 2/770 11/18722 0.072652987141932 0.315631939780512 HES1/CTNNB1 2 GO:0060767 epithelial cell proliferation involved in prostate gland development 2/770 11/18722 0.072652987141932 0.315631939780512 CTNNB1/SERPINF1 2 GO:0061635 regulation of protein complex stability 2/770 11/18722 0.072652987141932 0.315631939780512 SQSTM1/HSPA8 2 GO:0070417 cellular response to cold 2/770 11/18722 0.072652987141932 0.315631939780512 NFKBIA/SLC9A1 2 GO:0071492 cellular response to UV-A 2/770 11/18722 0.072652987141932 0.315631939780512 MME/OPN3 2 GO:0071609 chemokine (C-C motif) ligand 5 production 2/770 11/18722 0.072652987141932 0.315631939780512 ARG2/DDX3X 2 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 2/770 11/18722 0.072652987141932 0.315631939780512 ARG2/DDX3X 2 GO:0072173 metanephric tubule morphogenesis 2/770 11/18722 0.072652987141932 0.315631939780512 HES1/LGR4 2 GO:0072205 metanephric collecting duct development 2/770 11/18722 0.072652987141932 0.315631939780512 AKR1B1/DLG5 2 GO:0072497 mesenchymal stem cell differentiation 2/770 11/18722 0.072652987141932 0.315631939780512 KRT18/CTNNB1 2 GO:0090160 Golgi to lysosome transport 2/770 11/18722 0.072652987141932 0.315631939780512 EHD3/CLN3 2 GO:0098792 xenophagy 2/770 11/18722 0.072652987141932 0.315631939780512 LGALS8/TBK1 2 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 2/770 11/18722 0.072652987141932 0.315631939780512 HES1/NFE2L2 2 GO:1902915 negative regulation of protein polyubiquitination 2/770 11/18722 0.072652987141932 0.315631939780512 OTUB2/UBR5 2 GO:1903897 regulation of PERK-mediated unfolded protein response 2/770 11/18722 0.072652987141932 0.315631939780512 HSPA5/TMEM33 2 GO:1904321 response to forskolin 2/770 11/18722 0.072652987141932 0.315631939780512 FDX1/GNAI1 2 GO:1904322 cellular response to forskolin 2/770 11/18722 0.072652987141932 0.315631939780512 FDX1/GNAI1 2 GO:2000644 regulation of receptor catabolic process 2/770 11/18722 0.072652987141932 0.315631939780512 MYLIP/FURIN 2 GO:0106106 cold-induced thermogenesis 10/770 144/18722 0.0736414130347563 0.316870153169584 GADD45G/ESRRG/CEBPB/ARRDC3/DDIT3/EPAS1/LGR4/GNAS/PRLR/RHEB 10 GO:0120161 regulation of cold-induced thermogenesis 10/770 144/18722 0.0736414130347563 0.316870153169584 GADD45G/ESRRG/CEBPB/ARRDC3/DDIT3/EPAS1/LGR4/GNAS/PRLR/RHEB 10 GO:1900407 regulation of cellular response to oxidative stress 7/770 89/18722 0.0736595141489084 0.316870153169584 HSPB1/P4HB/PNPLA8/CTNNB1/UBQLN1/SOD1/NFE2L2 7 GO:0071322 cellular response to carbohydrate stimulus 11/770 163/18722 0.0736774941210025 0.316870153169584 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/COLEC12/OSBP/CCDC186/SERPINF1 11 GO:0008637 apoptotic mitochondrial changes 8/770 107/18722 0.0738114521675005 0.316870153169584 PMAIP1/BCL2/IFI6/SLC25A5/LMNA/PRELID1/GHITM/HSPD1 8 GO:0001779 natural killer cell differentiation 3/770 24/18722 0.073891855906694 0.316870153169584 HECTD1/NFIL3/PBX1 3 GO:0001783 B cell apoptotic process 3/770 24/18722 0.073891855906694 0.316870153169584 TNFRSF21/IRS2/FNIP1 3 GO:0002726 positive regulation of T cell cytokine production 3/770 24/18722 0.073891855906694 0.316870153169584 PRKCZ/GATA3/CD55 3 GO:0006582 melanin metabolic process 3/770 24/18722 0.073891855906694 0.316870153169584 BCL2/OPN3/DDT 3 GO:0010226 response to lithium ion 3/770 24/18722 0.073891855906694 0.316870153169584 CEBPA/CALR/NFE2L2 3 GO:0018196 peptidyl-asparagine modification 3/770 24/18722 0.073891855906694 0.316870153169584 TUSC3/RPN2/DDOST 3 GO:0050820 positive regulation of coagulation 3/770 24/18722 0.073891855906694 0.316870153169584 ST3GAL4/SERPINE1/NFE2L2 3 GO:0051647 nucleus localization 3/770 24/18722 0.073891855906694 0.316870153169584 HOOK3/SYNE2/PAFAH1B1 3 GO:0071378 cellular response to growth hormone stimulus 3/770 24/18722 0.073891855906694 0.316870153169584 GDF15/GHR/LEPROT 3 GO:2000679 positive regulation of transcription regulatory region DNA binding 3/770 24/18722 0.073891855906694 0.316870153169584 GATA3/GTF2B/CTNNB1 3 GO:0000768 syncytium formation by plasma membrane fusion 5/770 55/18722 0.0749150062505199 0.318135150426297 ERVFRD-1/GDF15/ERVW-1/GCM1/MYOF 5 GO:0010676 positive regulation of cellular carbohydrate metabolic process 5/770 55/18722 0.0749150062505199 0.318135150426297 PMAIP1/P2RY6/DDB1/IRS2/SORBS1 5 GO:0031113 regulation of microtubule polymerization 5/770 55/18722 0.0749150062505199 0.318135150426297 CLIP1/AKAP9/NUMA1/HSPA1B/CAMSAP2 5 GO:0043331 response to dsRNA 5/770 55/18722 0.0749150062505199 0.318135150426297 PMAIP1/SLC3A2/NFKBIA/DHX36/COLEC12 5 GO:0140253 cell-cell fusion 5/770 55/18722 0.0749150062505199 0.318135150426297 ERVFRD-1/GDF15/ERVW-1/GCM1/MYOF 5 GO:1905517 macrophage migration 5/770 55/18722 0.0749150062505199 0.318135150426297 CD200/MTUS1/AKIRIN1/DDT/MIF 5 GO:0010463 mesenchymal cell proliferation 4/770 39/18722 0.0750680218957116 0.318135150426297 LMNA/IRS2/CTNNB1/GPC3 4 GO:0016233 telomere capping 4/770 39/18722 0.0750680218957116 0.318135150426297 NEK7/PKIB/TNKS2/MAP3K4 4 GO:0017158 regulation of calcium ion-dependent exocytosis 4/770 39/18722 0.0750680218957116 0.318135150426297 RAP1B/SYT7/ARF1/STXBP3 4 GO:0034314 Arp2/3 complex-mediated actin nucleation 4/770 39/18722 0.0750680218957116 0.318135150426297 WASL/JMY/ARF1/IQGAP2 4 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 4/770 39/18722 0.0750680218957116 0.318135150426297 ANXA1/PRKCZ/CD55/SOCS1 4 GO:2000785 regulation of autophagosome assembly 4/770 39/18722 0.0750680218957116 0.318135150426297 NUPR1/FEZ2/RAB5A/CHMP4B 4 GO:0007599 hemostasis 14/770 222/18722 0.0750806616298064 0.318135150426297 HSPB1/ST3GAL4/SERPINB2/VAV3/FBLN1/SERPINE1/GNA12/AK3/GNAS/F5/C1QTNF1/CD59/STXBP3/NFE2L2 14 GO:0050817 coagulation 14/770 222/18722 0.0750806616298064 0.318135150426297 HSPB1/ST3GAL4/SERPINB2/VAV3/FBLN1/SERPINE1/GNA12/AK3/GNAS/F5/C1QTNF1/CD59/STXBP3/NFE2L2 14 GO:0045786 negative regulation of cell cycle 22/770 385/18722 0.0758546474889954 0.321141638434719 BTG3/NUPR1/CDKN1C/PDCD4/EGFR/GATA3/NABP1/HEXIM1/OVOL1/BCL2/BTG1/CEBPA/LATS2/FOXO4/MDM2/CDK2/PPP1R10/CTNNB1/GIGYF2/USP47/TAOK1/CHMP2A 22 GO:0061351 neural precursor cell proliferation 10/770 145/18722 0.0763437618991245 0.322938001310133 SPINT1/GLI3/TEAD3/HOOK3/GATA2/ID2/ADGRG1/SPINT2/CTNNB1/PAFAH1B1 10 GO:0034446 substrate adhesion-dependent cell spreading 8/770 108/18722 0.0770021203938549 0.325101188747281 FBLN1/P4HB/RAB1A/CALR/KANK1/NRP1/ACTN4/FERMT2 8 GO:0090130 tissue migration 21/770 365/18722 0.0770567424009708 0.325101188747281 ANXA1/HSPB1/S100P/HMOX1/PIK3C2A/GATA3/RAB11A/EPHB4/PLPP3/HDAC5/GATA2/JUP/PPARD/PDPK1/LGALS8/CALR/KANK1/NRP1/SERPINF1/PDCD6/NFE2L2 21 GO:0030901 midbrain development 7/770 90/18722 0.0771919804522257 0.325101188747281 BASP1/HES1/HSPA5/DLG5/CTNNB1/DYNLL1/CSNK1E 7 GO:0042475 odontogenesis of dentin-containing tooth 7/770 90/18722 0.0771919804522257 0.325101188747281 CSF3R/SERPINE1/GLI3/SLC4A2/CTNNB1/BSG/ADM 7 GO:0061097 regulation of protein tyrosine kinase activity 7/770 90/18722 0.0771919804522257 0.325101188747281 APP/ERBB3/MVP/TSG101/SNX6/RAP2C/ERRFI1 7 GO:0002274 myeloid leukocyte activation 14/770 223/18722 0.0772465999351355 0.325101188747281 HMOX1/APP/CD200/DYSF/JUND/GATA2/CEBPA/PDPK1/LDLR/PI4K2A/STXBP3/SNAP23/MIF/HSPD1 14 GO:0048659 smooth muscle cell proliferation 12/770 184/18722 0.0779017071061099 0.327581608868984 HMOX1/PDCD4/EGFR/AKR1B1/GNA12/TGM2/ERN1/P2RY6/ID2/PPARD/MDM2/CTNNB1 12 GO:0030048 actin filament-based movement 9/770 127/18722 0.0786330643893286 0.329822020077461 NEDD4L/DSP/AKAP9/WASL/JUP/SYNE2/MYO6/SLC9A1/ACTN4 9 GO:0035270 endocrine system development 9/770 127/18722 0.0786330643893286 0.329822020077461 CGA/ANXA1/ARID5B/GATA3/HES1/GATA2/PDPK1/PBX1/RHEB 9 GO:0048565 digestive tract development 9/770 127/18722 0.0786330643893286 0.329822020077461 EGFR/HES1/BCL2/LGR4/GLI3/YIPF6/ID2/SLC4A2/CTNNB1 9 GO:1901888 regulation of cell junction assembly 13/770 204/18722 0.0789356017798518 0.33007112741529 APP/FMN1/RAP1B/PHLDB2/DLG5/RAPGEF1/DUSP3/CRB3/LRP1/SLK/SLC9A1/NRP1/FERMT2 13 GO:0010675 regulation of cellular carbohydrate metabolic process 10/770 146/18722 0.0791070712525965 0.33007112741529 NUPR1/PMAIP1/PHLDA2/P2RY6/DDB1/IRS2/C1QTNF1/SORBS1/SLC35B4/PPP1CB 10 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 16/770 264/18722 0.0793552102629197 0.33007112741529 PRKCZ/EGFR/APP/HES1/GHR/SOCS1/ERBB3/MVP/RICTOR/TSG101/SNX6/OSBP/NRP1/MIF/RAP2C/ERRFI1 16 GO:0032456 endocytic recycling 6/770 73/18722 0.0795071173869952 0.33007112741529 RAB11A/SNX27/EHD3/GRIP1/VPS26A/RAB7A 6 GO:0043299 leukocyte degranulation 6/770 73/18722 0.0795071173869952 0.33007112741529 HMOX1/GATA2/PDPK1/PI4K2A/STXBP3/SNAP23 6 GO:0051145 smooth muscle cell differentiation 6/770 73/18722 0.0795071173869952 0.33007112741529 TBX3/PDCD4/HES1/FOXO4/CTNNB1/ADM 6 GO:0051298 centrosome duplication 6/770 73/18722 0.0795071173869952 0.33007112741529 CHMP2B/CDK2/VPS4B/CEP152/CHMP4B/CHMP2A 6 GO:0051865 protein autoubiquitination 6/770 73/18722 0.0795071173869952 0.33007112741529 UBE2B/UBE2A/HECTD1/KLHL24/RNF11/MDM2 6 GO:0002090 regulation of receptor internalization 5/770 56/18722 0.0796198063723016 0.33007112741529 CD63/LRPAP1/OPHN1/ARF1/AP2M1 5 GO:0010518 positive regulation of phospholipase activity 5/770 56/18722 0.0796198063723016 0.33007112741529 PRKCZ/EGFR/ARF4/P2RY6/PDPK1 5 GO:0043388 positive regulation of DNA binding 5/770 56/18722 0.0796198063723016 0.33007112741529 GATA3/HES1/EDF1/GTF2B/CTNNB1 5 GO:0045599 negative regulation of fat cell differentiation 5/770 56/18722 0.0796198063723016 0.33007112741529 GATA3/DDIT3/GATA2/INSIG1/FERMT2 5 GO:0048008 platelet-derived growth factor receptor signaling pathway 5/770 56/18722 0.0796198063723016 0.33007112741529 ARID5B/PIK3C2A/LRP1/NRP1/ZFAND5 5 GO:0070534 protein K63-linked ubiquitination 5/770 56/18722 0.0796198063723016 0.33007112741529 UBE2B/OTUB2/HECTD1/UBR5/DDX3X 5 GO:0006821 chloride transport 8/770 109/18722 0.0802742552774795 0.332507576099485 SLC26A2/FXYD3/CLIC3/GABRE/P2RY6/CLCN3/SLC12A4/CLDN4 8 GO:0043433 negative regulation of DNA-binding transcription factor activity 12/770 185/18722 0.0803640307107738 0.332582956589779 NUPR1/HMOX1/TAX1BP1/HES1/DDIT3/CD200/NFKBIA/ID2/BHLHE40/ANXA4/COMMD1/COMMD7 12 GO:0002275 myeloid cell activation involved in immune response 7/770 91/18722 0.0808217748367317 0.332582956589779 HMOX1/DYSF/GATA2/PDPK1/PI4K2A/STXBP3/SNAP23 7 GO:0006354 DNA-templated transcription, elongation 7/770 91/18722 0.0808217748367317 0.332582956589779 HEXIM1/ADRM1/CTNNB1/SUPT6H/SERTAD1/BRD4/ALYREF 7 GO:0014033 neural crest cell differentiation 7/770 91/18722 0.0808217748367317 0.332582956589779 SEMA6A/HES1/ANXA6/SEMA7A/RDH10/NRP1/PDCD6 7 GO:0045582 positive regulation of T cell differentiation 7/770 91/18722 0.0808217748367317 0.332582956589779 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/CD46 7 GO:0098661 inorganic anion transmembrane transport 7/770 91/18722 0.0808217748367317 0.332582956589779 SLC26A2/SLC13A4/GABRE/SLC5A6/CLCN3/SLC12A4/SLC20A1 7 GO:0072210 metanephric nephron development 4/770 40/18722 0.0808264018523425 0.332582956589779 HES1/LGR4/FMN1/CTNNB1 4 GO:2000142 regulation of DNA-templated transcription, initiation 4/770 40/18722 0.0808264018523425 0.332582956589779 MED13/DHX36/SUB1/PSMC6 4 GO:0033233 regulation of protein sumoylation 3/770 25/18722 0.0815080039314934 0.334558800321772 CTNNB1/HMG20B/UBE2I 3 GO:0045109 intermediate filament organization 3/770 25/18722 0.0815080039314934 0.334558800321772 DSP/KLHL24/DNAJB6 3 GO:0061436 establishment of skin barrier 3/770 25/18722 0.0815080039314934 0.334558800321772 GRHL1/LSR/CLDN4 3 GO:0006650 glycerophospholipid metabolic process 18/770 306/18722 0.0820305321778213 0.336426454191015 PIK3C2A/MTMR10/SERINC5/ABHD5/ABHD3/SOCS1/CLN3/TTC7B/SH3YL1/PNPLA8/LDLR/PI4K2A/SYNJ1/PRDX6/PAFAH1B1/PTDSS1/SLC44A1/TMEM150A 18 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 12/770 186/18722 0.0828749658156971 0.338617828758271 TFRC/HMOX1/TGM2/DHX36/CANT1/CTNNB1/TBK1/BRD4/SLC20A1/TFG/TMED4/UBE2I 12 GO:0043087 regulation of GTPase activity 20/770 348/18722 0.0835548146619606 0.338617828758271 RASA1/VAV3/TGM2/RASAL2/EIF5/SH3BP4/FGD6/TBC1D9/ARHGAP24/DVL3/TBC1D20/SNX9/RAPGEF1/RICTOR/RABGAP1/PAFAH1B1/CDKL5/SOD1/FERMT2/IQGAP2 20 GO:0003014 renal system process 8/770 110/18722 0.0836277968666002 0.338617828758271 SGK1/HSD11B2/AKR1B1/BCL2/CLN3/MLLT6/ADM/CLDN4 8 GO:0018958 phenol-containing compound metabolic process 8/770 110/18722 0.0836277968666002 0.338617828758271 CGA/GATA3/AKR1B1/BCL2/EPAS1/OPN3/MAOA/DDT 8 GO:0051881 regulation of mitochondrial membrane potential 6/770 74/18722 0.0836787826684292 0.338617828758271 PMAIP1/BCL2/IFI6/VCP/PRELID1/SOD1 6 GO:1903201 regulation of oxidative stress-induced cell death 6/770 74/18722 0.0836787826684292 0.338617828758271 HSPB1/P4HB/CTNNB1/UBQLN1/SOD1/NFE2L2 6 GO:0007254 JNK cascade 11/770 167/18722 0.0841051976509459 0.338617828758271 GADD45G/PDCD4/EGFR/APP/DUSP9/DUSP3/MAP3K13/PHLPP1/PAFAH1B1/DNAJA1/TAOK1 11 GO:0006949 syncytium formation 5/770 57/18722 0.0844788622357811 0.338617828758271 ERVFRD-1/GDF15/ERVW-1/GCM1/MYOF 5 GO:0035148 tube formation 10/770 148/18722 0.0848168895400087 0.338617828758271 GATA3/SPINT1/TGM2/HECTD1/MIB1/DVL3/SPINT2/BRD2/CTNNB1/ADM 10 GO:0044839 cell cycle G2/M phase transition 10/770 148/18722 0.0848168895400087 0.338617828758271 NABP1/RAB11A/APP/FOXO4/CDK2/VPS4B/BRD4/PBX1/USP47/TAOK1 10 GO:0002328 pro-B cell differentiation 2/770 12/18722 0.084875309676717 0.338617828758271 HES1/FNIP1 2 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/770 12/18722 0.084875309676717 0.338617828758271 HSPA5/CHMP4B 2 GO:0006703 estrogen biosynthetic process 2/770 12/18722 0.084875309676717 0.338617828758271 CYP19A1/HSD17B1 2 GO:0019627 urea metabolic process 2/770 12/18722 0.084875309676717 0.338617828758271 ARG2/CEBPA 2 GO:0021559 trigeminal nerve development 2/770 12/18722 0.084875309676717 0.338617828758271 TFAP2A/NRP1 2 GO:0021781 glial cell fate commitment 2/770 12/18722 0.084875309676717 0.338617828758271 GCM1/CTNNB1 2 GO:0031953 negative regulation of protein autophosphorylation 2/770 12/18722 0.084875309676717 0.338617828758271 MVP/ERRFI1 2 GO:0032736 positive regulation of interleukin-13 production 2/770 12/18722 0.084875309676717 0.338617828758271 PRKCZ/GATA3 2 GO:0033127 regulation of histone phosphorylation 2/770 12/18722 0.084875309676717 0.338617828758271 UBE2B/RPS6KA5 2 GO:0033182 regulation of histone ubiquitination 2/770 12/18722 0.084875309676717 0.338617828758271 OTUB2/UBR5 2 GO:0045117 azole transmembrane transport 2/770 12/18722 0.084875309676717 0.338617828758271 SLC19A2/SLC19A3 2 GO:0046831 regulation of RNA export from nucleus 2/770 12/18722 0.084875309676717 0.338617828758271 SUPT6H/IWS1 2 GO:0060788 ectodermal placode formation 2/770 12/18722 0.084875309676717 0.338617828758271 TBX3/CTNNB1 2 GO:0070170 regulation of tooth mineralization 2/770 12/18722 0.084875309676717 0.338617828758271 TFAP2A/SLC4A2 2 GO:0071287 cellular response to manganese ion 2/770 12/18722 0.084875309676717 0.338617828758271 APP/HSPA5 2 GO:0071697 ectodermal placode morphogenesis 2/770 12/18722 0.084875309676717 0.338617828758271 TBX3/CTNNB1 2 GO:0071941 nitrogen cycle metabolic process 2/770 12/18722 0.084875309676717 0.338617828758271 ARG2/CEBPA 2 GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/770 12/18722 0.084875309676717 0.338617828758271 GATA3/CTNNB1 2 GO:0072520 seminiferous tubule development 2/770 12/18722 0.084875309676717 0.338617828758271 TBC1D20/ADGRG1 2 GO:0072584 caveolin-mediated endocytosis 2/770 12/18722 0.084875309676717 0.338617828758271 NEDD4L/CLN3 2 GO:0098911 regulation of ventricular cardiac muscle cell action potential 2/770 12/18722 0.084875309676717 0.338617828758271 DSP/JUP 2 GO:1903332 regulation of protein folding 2/770 12/18722 0.084875309676717 0.338617828758271 HSPA5/ST13 2 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 2/770 12/18722 0.084875309676717 0.338617828758271 CTNNB1/CSNK1E 2 GO:2000303 regulation of ceramide biosynthetic process 2/770 12/18722 0.084875309676717 0.338617828758271 SAMD8/ORMDL1 2 GO:0050679 positive regulation of epithelial cell proliferation 13/770 207/18722 0.086121040315233 0.343312915112645 PGF/HMOX1/EGFR/ZNF703/GATA2/PDPK1/KDM5B/CTNNB1/DLX5/RICTOR/NRP1/PDCD6/MYDGF 13 GO:0001953 negative regulation of cell-matrix adhesion 4/770 41/18722 0.0867964285178711 0.343461529293685 RASA1/SERPINE1/PHLDB2/LRP1 4 GO:0007099 centriole replication 4/770 41/18722 0.0867964285178711 0.343461529293685 CDK2/VPS4B/CEP152/CHMP2A 4 GO:0010907 positive regulation of glucose metabolic process 4/770 41/18722 0.0867964285178711 0.343461529293685 PMAIP1/DDB1/IRS2/SORBS1 4 GO:0032733 positive regulation of interleukin-10 production 4/770 41/18722 0.0867964285178711 0.343461529293685 PRKCZ/CD274/CD46/HSPD1 4 GO:0048286 lung alveolus development 4/770 41/18722 0.0867964285178711 0.343461529293685 MAN1A2/HOPX/STK40/ERRFI1 4 GO:0060612 adipose tissue development 4/770 41/18722 0.0867964285178711 0.343461529293685 ARID5B/PGRMC2/ARRDC3/PPARD 4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 4/770 41/18722 0.0867964285178711 0.343461529293685 P4HB/CALR/NRP1/FERMT2 4 GO:1902116 negative regulation of organelle assembly 4/770 41/18722 0.0867964285178711 0.343461529293685 NUPR1/LIMK2/FEZ2/CHMP4B 4 GO:2000008 regulation of protein localization to cell surface 4/770 41/18722 0.0867964285178711 0.343461529293685 NEDD4L/LEPROT/CTNNB1/COMMD1 4 GO:0099173 postsynapse organization 11/770 168/18722 0.0868475871784152 0.343461529293685 DHX36/WASL/ARF4/OPHN1/RER1/CHMP2B/ARF1/NRP1/PAFAH1B1/CDKL5/HSPA8 11 GO:0001938 positive regulation of endothelial cell proliferation 8/770 111/18722 0.0870626196400055 0.344038884747143 PGF/HMOX1/GATA2/PDPK1/RICTOR/NRP1/PDCD6/MYDGF 8 GO:0050708 regulation of protein secretion 16/770 268/18722 0.0877831032684094 0.346611096344282 ANXA1/EGFR/EZR/KCNN4/PIM3/CD200/SERP1/SYT7/ABCG1/PPARD/ARF1/IRS2/DYNLL1/LRP1/OSBP/RAB11FIP1 16 GO:0007098 centrosome cycle 9/770 130/18722 0.0879514862089831 0.346797271896612 GOLGA2/CHMP2B/UVRAG/CDK2/CTNNB1/VPS4B/CEP152/CHMP4B/CHMP2A 9 GO:0045913 positive regulation of carbohydrate metabolic process 6/770 75/18722 0.0879694464534052 0.346797271896612 PMAIP1/APP/P2RY6/DDB1/IRS2/SORBS1 6 GO:0048839 inner ear development 12/770 188/18722 0.0880429836023318 0.346812796277011 GATA3/TFAP2A/HES1/GLI3/GATA2/CEBPA/TRIP11/DLX5/MYO6/INSIG1/PAFAH1B1/SOD1 12 GO:0032088 negative regulation of NF-kappaB transcription factor activity 7/770 93/18722 0.0883722448279819 0.347560296746514 TAX1BP1/DDIT3/CD200/NFKBIA/ANXA4/COMMD1/COMMD7 7 GO:1901796 regulation of signal transduction by p53 class mediator 7/770 93/18722 0.0883722448279819 0.347560296746514 SGK1/PMAIP1/HEXIM1/PTTG1IP/BCL2/MDM2/MIF 7 GO:0006517 protein deglycosylation 3/770 26/18722 0.089446823114567 0.348928752263163 MAN1A2/EDEM1/MAN1C1 3 GO:0006760 folic acid-containing compound metabolic process 3/770 26/18722 0.089446823114567 0.348928752263163 SLC19A1/GGH/MTHFS 3 GO:0010875 positive regulation of cholesterol efflux 3/770 26/18722 0.089446823114567 0.348928752263163 NFKBIA/ABCG1/LRP1 3 GO:0034063 stress granule assembly 3/770 26/18722 0.089446823114567 0.348928752263163 PRRC2C/GRB7/DDX3X 3 GO:0046639 negative regulation of alpha-beta T cell differentiation 3/770 26/18722 0.089446823114567 0.348928752263163 ANXA1/GLI3/SOCS1 3 GO:0048843 negative regulation of axon extension involved in axon guidance 3/770 26/18722 0.089446823114567 0.348928752263163 SEMA6A/SEMA7A/NRP1 3 GO:2000050 regulation of non-canonical Wnt signaling pathway 3/770 26/18722 0.089446823114567 0.348928752263163 DAB2/CSNK1E/GPC3 3 GO:0032481 positive regulation of type I interferon production 5/770 58/18722 0.08949045663101 0.348928752263163 DHX36/DDX3X/TBK1/HSP90AA1/HSPD1 5 GO:0043525 positive regulation of neuron apoptotic process 5/770 58/18722 0.08949045663101 0.348928752263163 NUPR1/TFAP2A/DDIT3/UBE2M/CTNNB1 5 GO:1902808 positive regulation of cell cycle G1/S phase transition 5/770 58/18722 0.08949045663101 0.348928752263163 ANXA1/EGFR/MDM2/DDX3X/CCND3 5 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 5/770 58/18722 0.08949045663101 0.348928752263163 NUPR1/SIAH1/PMAIP1/DDIT3/SOD1 5 GO:0046632 alpha-beta T cell differentiation 8/770 112/18722 0.0905785329112923 0.352895097339304 ANXA1/PRKCZ/GATA3/CTSL/PNP/BCL2/GLI3/SOCS1 8 GO:0046883 regulation of hormone secretion 15/770 249/18722 0.0906747622709168 0.352994015934358 CYP19A1/ANXA1/EGFR/PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/KDM5B/C1QTNF1/DYNLL1/LRP1/OSBP/RAB11FIP1 15 GO:0045444 fat cell differentiation 14/770 229/18722 0.0910875945978824 0.354197723019286 ARID5B/CEBPB/GATA3/ARL4A/HES1/DDIT3/SOCS1/GATA2/ID2/CEBPA/PPARD/SYAP1/INSIG1/FERMT2 14 GO:0000723 telomere maintenance 9/770 131/18722 0.0911972062279237 0.354197723019286 NEK7/DHX36/PKIB/TNKS2/XRN1/PPP1R10/CTNNB1/MAP3K4/HSP90AA1 9 GO:0018022 peptidyl-lysine methylation 9/770 131/18722 0.0911972062279237 0.354197723019286 GATA3/KMT2C/TET2/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/BRD4 9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 7/770 94/18722 0.0922921351030937 0.357336215399158 CDKN1C/EGFR/HEXIM1/CEBPA/LATS2/SERTAD1/CCND3 7 GO:0002042 cell migration involved in sprouting angiogenesis 7/770 94/18722 0.0922921351030937 0.357336215399158 ANXA1/HMOX1/PIK3C2A/EPHB4/HDAC5/GATA2/NRP1 7 GO:0051702 biological process involved in interaction with symbiont 7/770 94/18722 0.0922921351030937 0.357336215399158 TBC1D20/DDB1/PPIB/PSMC3/STOM/HSPA8/HSPD1 7 GO:1990830 cellular response to leukemia inhibitory factor 7/770 94/18722 0.0922921351030937 0.357336215399158 ARID5B/TFRC/NFYB/PCOLCE2/SLC25A5/KDM5B/RNMT 7 GO:0007520 myoblast fusion 4/770 42/18722 0.0929736507113053 0.358304486847977 ERVFRD-1/GDF15/ERVW-1/MYOF 4 GO:0021795 cerebral cortex cell migration 4/770 42/18722 0.0929736507113053 0.358304486847977 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0043507 positive regulation of JUN kinase activity 4/770 42/18722 0.0929736507113053 0.358304486847977 ERN1/DVL3/MAP3K13/MAP3K4 4 GO:0045047 protein targeting to ER 4/770 42/18722 0.0929736507113053 0.358304486847977 HERPUD1/HSPA5/EDEM1/CHMP4B 4 GO:0045687 positive regulation of glial cell differentiation 4/770 42/18722 0.0929736507113053 0.358304486847977 SPINT1/HES1/ID2/RHEB 4 GO:0046688 response to copper ion 4/770 42/18722 0.0929736507113053 0.358304486847977 APP/MAP1LC3A/SOD1/NFE2L2 4 GO:0030595 leukocyte chemotaxis 14/770 230/18722 0.0935360573303721 0.35991519202876 ANXA1/PGF/CSF3R/VAV3/SERPINE1/MPP1/SBDS/MTUS1/AKIRIN1/BSG/DDT/PPIB/CALR/MIF 14 GO:0045333 cellular respiration 14/770 230/18722 0.0935360573303721 0.35991519202876 NUPR1/NDUFA6/COQ10B/VCP/COX6C/OPN3/IL10RB/PRELID1/ACO2/COX4I1/GHITM/COX7B/COX6A1/NDUFB9 14 GO:0043410 positive regulation of MAPK cascade 26/770 480/18722 0.0936101863006556 0.359922498716178 GDF15/GADD45G/PRKCZ/EGFR/APP/SPAG9/BRAF/SEMA7A/GHR/ERN1/RAP1B/P2RY6/DVL3/CTNNB1/C1QTNF1/DDT/LRP1/MAP3K13/GAREM1/NRP1/MIF/MAP3K4/TAOK1/MYDGF/SOD1/FERMT2 26 GO:0043535 regulation of blood vessel endothelial cell migration 10/770 151/18722 0.0938398656359966 0.360249653670394 ANXA1/HSPB1/HMOX1/PIK3C2A/HDAC5/GATA2/JUP/PDPK1/NRP1/NFE2L2 10 GO:0071333 cellular response to glucose stimulus 10/770 151/18722 0.0938398656359966 0.360249653670394 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/SERPINF1 10 GO:0045667 regulation of osteoblast differentiation 9/770 132/18722 0.0945125291067886 0.362273794260867 CEBPB/CRIM1/GLI3/SMOC1/JUND/CEBPA/CTNNB1/SUCO/FERMT2 9 GO:0072175 epithelial tube formation 9/770 132/18722 0.0945125291067886 0.362273794260867 GATA3/SPINT1/HECTD1/MIB1/DVL3/SPINT2/BRD2/CTNNB1/ADM 9 GO:0048469 cell maturation 11/770 171/18722 0.0954004329507395 0.363503804669754 GLDN/GATA3/APP/AKR1B1/HES1/BCL2/EPAS1/GATA2/CEBPA/CTNNB1/MAP3K13 11 GO:1990823 response to leukemia inhibitory factor 7/770 95/18722 0.0963077853814491 0.363503804669754 ARID5B/TFRC/NFYB/PCOLCE2/SLC25A5/KDM5B/RNMT 7 GO:0042180 cellular ketone metabolic process 13/770 211/18722 0.0963210076571804 0.363503804669754 ANXA1/HSD17B1/CYP11A1/KMO/AKR1B1/COQ10B/CLN3/PPARD/IRS2/ACADVL/RDH10/INSIG1/ADM 13 GO:0006367 transcription initiation from RNA polymerase II promoter 6/770 77/18722 0.0969041314786292 0.363503804669754 MED13/DHX36/GTF2B/TAF13/SUB1/PSMC6 6 GO:0021675 nerve development 6/770 77/18722 0.0969041314786292 0.363503804669754 TFAP2A/HES1/GLI3/ERBB3/CTNNB1/NRP1 6 GO:0006983 ER overload response 2/770 13/18722 0.097661447041419 0.363503804669754 DDIT3/HSPA5 2 GO:0010745 negative regulation of macrophage derived foam cell differentiation 2/770 13/18722 0.097661447041419 0.363503804669754 NFKBIA/ABCG1 2 GO:0010917 negative regulation of mitochondrial membrane potential 2/770 13/18722 0.097661447041419 0.363503804669754 PMAIP1/PRELID1 2 GO:0010960 magnesium ion homeostasis 2/770 13/18722 0.097661447041419 0.363503804669754 EGFR/CNNM2 2 GO:0014745 negative regulation of muscle adaptation 2/770 13/18722 0.097661447041419 0.363503804669754 LMNA/ERRFI1 2 GO:0014842 regulation of skeletal muscle satellite cell proliferation 2/770 13/18722 0.097661447041419 0.363503804669754 PPARD/AKIRIN1 2 GO:0015801 aromatic amino acid transport 2/770 13/18722 0.097661447041419 0.363503804669754 SLC3A2/SLC7A5 2 GO:0015809 arginine transport 2/770 13/18722 0.097661447041419 0.363503804669754 SLC38A9/CLN3 2 GO:0021514 ventral spinal cord interneuron differentiation 2/770 13/18722 0.097661447041419 0.363503804669754 GLI3/GATA2 2 GO:0035745 T-helper 2 cell cytokine production 2/770 13/18722 0.097661447041419 0.363503804669754 PRKCZ/GATA3 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/770 13/18722 0.097661447041419 0.363503804669754 ATF3/ZDHHC3 2 GO:0042541 hemoglobin biosynthetic process 2/770 13/18722 0.097661447041419 0.363503804669754 ALAS1/EIF2AK1 2 GO:0046415 urate metabolic process 2/770 13/18722 0.097661447041419 0.363503804669754 SLC22A11/PNP 2 GO:0046642 negative regulation of alpha-beta T cell proliferation 2/770 13/18722 0.097661447041419 0.363503804669754 ARG2/CD274 2 GO:0048711 positive regulation of astrocyte differentiation 2/770 13/18722 0.097661447041419 0.363503804669754 HES1/ID2 2 GO:0051451 myoblast migration 2/770 13/18722 0.097661447041419 0.363503804669754 ANXA1/AKIRIN1 2 GO:0061469 regulation of type B pancreatic cell proliferation 2/770 13/18722 0.097661447041419 0.363503804669754 NUPR1/ERRFI1 2 GO:0090153 regulation of sphingolipid biosynthetic process 2/770 13/18722 0.097661447041419 0.363503804669754 SAMD8/ORMDL1 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/770 13/18722 0.097661447041419 0.363503804669754 ERN1/TMEM33 2 GO:1901096 regulation of autophagosome maturation 2/770 13/18722 0.097661447041419 0.363503804669754 CLN3/UVRAG 2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/770 13/18722 0.097661447041419 0.363503804669754 PMAIP1/ATF3 2 GO:1905038 regulation of membrane lipid metabolic process 2/770 13/18722 0.097661447041419 0.363503804669754 SAMD8/ORMDL1 2 GO:1905244 regulation of modification of synaptic structure 2/770 13/18722 0.097661447041419 0.363503804669754 CLN3/CHMP2B 2 GO:1990403 embryonic brain development 2/770 13/18722 0.097661447041419 0.363503804669754 CTNNB1/TBC1D23 2 GO:2000551 regulation of T-helper 2 cell cytokine production 2/770 13/18722 0.097661447041419 0.363503804669754 PRKCZ/GATA3 2 GO:0007026 negative regulation of microtubule depolymerization 3/770 27/18722 0.0976943812318703 0.363503804669754 ATXN7/CAMSAP2/TAOK1 3 GO:0010561 negative regulation of glycoprotein biosynthetic process 3/770 27/18722 0.0976943812318703 0.363503804669754 BACE2/AGO2/TMEM59 3 GO:0033561 regulation of water loss via skin 3/770 27/18722 0.0976943812318703 0.363503804669754 GRHL1/LSR/CLDN4 3 GO:0035116 embryonic hindlimb morphogenesis 3/770 27/18722 0.0976943812318703 0.363503804669754 TBX3/CTNNB1/GPC3 3 GO:0035235 ionotropic glutamate receptor signaling pathway 3/770 27/18722 0.0976943812318703 0.363503804669754 APP/CPEB4/CLN3 3 GO:0036037 CD8-positive, alpha-beta T cell activation 3/770 27/18722 0.0976943812318703 0.363503804669754 BCL2/SOCS1/CD274 3 GO:0048873 homeostasis of number of cells within a tissue 3/770 27/18722 0.0976943812318703 0.363503804669754 BCL2/GATA2/GIGYF2 3 GO:0098901 regulation of cardiac muscle cell action potential 3/770 27/18722 0.0976943812318703 0.363503804669754 DSP/AKAP9/JUP 3 GO:1902914 regulation of protein polyubiquitination 3/770 27/18722 0.0976943812318703 0.363503804669754 OTUB2/UBR5/DDX3X 3 GO:0051261 protein depolymerization 8/770 114/18722 0.0978525454757965 0.363503804669754 SCIN/CCSAP/ATXN7/VPS4B/SYNJ1/CAMSAP2/HSPA8/TAOK1 8 GO:0006997 nucleus organization 9/770 133/18722 0.0978972718978144 0.363503804669754 ATXN7/CHMP2B/LMNA/NUMA1/VPS4B/CHMP4B/PAFAH1B1/CHMP2A/UBE2I 9 GO:0046328 regulation of JNK cascade 9/770 133/18722 0.0978972718978144 0.363503804669754 GADD45G/PDCD4/EGFR/APP/DUSP3/PHLPP1/PAFAH1B1/DNAJA1/TAOK1 9 GO:0001678 cellular glucose homeostasis 11/770 172/18722 0.098359847872626 0.364949457892253 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SERPINF1 11 GO:0001709 cell fate determination 4/770 43/18722 0.0993532529894495 0.367540653041148 GATA3/HES1/GATA2/CTNNB1 4 GO:0030517 negative regulation of axon extension 4/770 43/18722 0.0993532529894495 0.367540653041148 SEMA6A/SEMA7A/DIP2B/NRP1 4 GO:0031952 regulation of protein autophosphorylation 4/770 43/18722 0.0993532529894495 0.367540653041148 MVP/DDX3X/RAP2C/ERRFI1 4 GO:0060443 mammary gland morphogenesis 4/770 43/18722 0.0993532529894495 0.367540653041148 TBX3/GLI3/ELF3/KDM5B 4 GO:0006893 Golgi to plasma membrane transport 5/770 60/18722 0.0999632853880618 0.369249111259238 GOLGA4/KRT18/CLN3/EXOC6B/COMMD1 5 GO:0051851 modulation by host of symbiont process 5/770 60/18722 0.0999632853880618 0.369249111259238 TBC1D20/PPIB/PSMC3/STOM/HSPA8 5 GO:0071331 cellular response to hexose stimulus 10/770 153/18722 0.10016003738632 0.369701826885949 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/SERPINF1 10 GO:0002718 regulation of cytokine production involved in immune response 7/770 96/18722 0.100418575248756 0.369834264940542 PRKCZ/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36 7 GO:0015914 phospholipid transport 7/770 96/18722 0.100418575248756 0.369834264940542 ATP10D/KCNN4/PITPNA/ABCG1/GLTP/PRELID1/LDLR 7 GO:0042472 inner ear morphogenesis 7/770 96/18722 0.100418575248756 0.369834264940542 GATA3/TFAP2A/GATA2/DLX5/MYO6/INSIG1/SOD1 7 GO:1904062 regulation of cation transmembrane transport 20/770 357/18722 0.101109191522569 0.372102733646205 FXYD3/SLC43A2/NEDD4L/APP/KCNN4/CD63/EHD3/AKAP9/P2RY6/KLHL24/PDPK1/ARF1/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COX17/COMMD1/ACTN4 20 GO:0000910 cytokinesis 11/770 173/18722 0.101373379385903 0.372799667512882 RAB11A/RASA1/SPIRE2/SNX9/CHMP2B/UVRAG/ARF1/VPS4B/CHMP4B/USP8/CHMP2A 11 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 6/770 78/18722 0.101545995480167 0.37315906746141 ANXA1/HMOX1/PIK3C2A/HDAC5/GATA2/NRP1 6 GO:0030900 forebrain development 21/770 379/18722 0.103068201571097 0.37843625584827 TBX3/TACC2/SLC2A1/GNG12/APP/HES1/GLI3/C21orf91/SEMA7A/HOOK3/GATA2/OPHN1/ID2/ADGRG1/CTNNB1/DLX5/LRP1/NRP1/DNAJB1/TACC1/PAFAH1B1 21 GO:0007265 Ras protein signal transduction 19/770 337/18722 0.103133942492866 0.37843625584827 SQSTM1/EPS8L1/RASA1/RAB9A/GNA12/RAP1B/ARHGAP24/OPHN1/CDC42EP4/ADGRG1/RAPGEF1/RAB21/CDK2/RAB4B/KANK1/NRP1/LRRC59/RAP2C/USP8 19 GO:0071326 cellular response to monosaccharide stimulus 10/770 154/18722 0.103411198641951 0.379174395020486 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/SERPINF1 10 GO:0001659 temperature homeostasis 11/770 174/18722 0.104440915489901 0.382668442563364 GADD45G/ESRRG/CEBPB/ARRDC3/DDIT3/EPAS1/LGR4/GNAS/ACADVL/PRLR/RHEB 11 GO:0006721 terpenoid metabolic process 7/770 97/18722 0.104623796016842 0.382775606132101 EGFR/AKR1B1/RDH13/PPARD/LRP1/PNPLA2/RDH10 7 GO:0043255 regulation of carbohydrate biosynthetic process 7/770 97/18722 0.104623796016842 0.382775606132101 AP2A1/P2RY6/DDB1/IRS2/SORBS1/SLC35B4/PPP1CB 7 GO:0007611 learning or memory 15/770 255/18722 0.105240003621874 0.383050282522477 PRKCZ/SGK1/EGFR/CEBPB/APP/MME/PAIP2/ARF4/CLN3/CLN8/LDLR/SYNJ1/EIF4A3/SERPINF1/PAFAH1B1 15 GO:0019748 secondary metabolic process 5/770 61/18722 0.105420007494114 0.383050282522477 AKR1B1/BCL2/OPN3/DDT/NFE2L2 5 GO:0006720 isoprenoid metabolic process 8/770 116/18722 0.105447027119143 0.383050282522477 EGFR/AKR1B1/RDH13/PPARD/IDI1/LRP1/PNPLA2/RDH10 8 GO:0021782 glial cell development 8/770 116/18722 0.105447027119143 0.383050282522477 EGFR/BACE2/APP/ITGB4/LDLR/LRP1/EIF2B2/SOD1 8 GO:0030326 embryonic limb morphogenesis 8/770 116/18722 0.105447027119143 0.383050282522477 TBX3/TFAP2A/GLI3/CTNNB1/DLX5/RDH10/GPC3/PBX1 8 GO:0035113 embryonic appendage morphogenesis 8/770 116/18722 0.105447027119143 0.383050282522477 TBX3/TFAP2A/GLI3/CTNNB1/DLX5/RDH10/GPC3/PBX1 8 GO:0043200 response to amino acid 8/770 116/18722 0.105447027119143 0.383050282522477 CEBPB/SLC38A9/CPEB4/SH3BP4/RRAGC/UBR1/SOCS1/CDO1 8 GO:0089718 amino acid import across plasma membrane 4/770 44/18722 0.105930085356226 0.383050282522477 SLC43A2/SLC3A2/SLC7A5/CLN8 4 GO:0097178 ruffle assembly 4/770 44/18722 0.105930085356226 0.383050282522477 EPS8L1/ARHGAP24/SH3YL1/KANK1 4 GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/770 44/18722 0.105930085356226 0.383050282522477 HERPUD1/DNAJB9/HSPA5/UBXN1 4 GO:0000423 mitophagy 3/770 28/18722 0.106236301514361 0.383050282522477 SQSTM1/MAP1LC3B/SLC25A5 3 GO:0010464 regulation of mesenchymal cell proliferation 3/770 28/18722 0.106236301514361 0.383050282522477 LMNA/IRS2/CTNNB1 3 GO:0032801 receptor catabolic process 3/770 28/18722 0.106236301514361 0.383050282522477 MYLIP/FURIN/UVRAG 3 GO:0045686 negative regulation of glial cell differentiation 3/770 28/18722 0.106236301514361 0.383050282522477 HES1/CTNNB1/LDLR 3 GO:0050996 positive regulation of lipid catabolic process 3/770 28/18722 0.106236301514361 0.383050282522477 ABHD5/IRS2/PNPLA2 3 GO:0051894 positive regulation of focal adhesion assembly 3/770 28/18722 0.106236301514361 0.383050282522477 FMN1/NRP1/FERMT2 3 GO:0061082 myeloid leukocyte cytokine production 3/770 28/18722 0.106236301514361 0.383050282522477 HMOX1/SEMA7A/DHX36 3 GO:0071280 cellular response to copper ion 3/770 28/18722 0.106236301514361 0.383050282522477 APP/MAP1LC3A/NFE2L2 3 GO:1903020 positive regulation of glycoprotein metabolic process 3/770 28/18722 0.106236301514361 0.383050282522477 GOLGA2/RAB1A/CTNNB1 3 GO:1903649 regulation of cytoplasmic transport 3/770 28/18722 0.106236301514361 0.383050282522477 DAB2/EZR/RAB21 3 GO:0002699 positive regulation of immune effector process 14/770 235/18722 0.106387148289082 0.38331681845589 ANXA1/PRKCZ/TFRC/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36/GATA2/DNAJB9/PDPK1/CD46/HSPD1 14 GO:0048771 tissue remodeling 11/770 175/18722 0.10756231624483 0.387270969543344 TFRC/EGFR/TGM2/EPAS1/LGR4/ELF3/SYT7/MDM2/CTNNB1/TMBIM1/SUCO 11 GO:0030073 insulin secretion 12/770 195/18722 0.107667355906348 0.387369266773524 ANXA1/PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3 12 GO:0007272 ensheathment of neurons 9/770 136/18722 0.108465489808275 0.388492958318077 SERINC5/EPB41L3/TNFRSF21/PPARD/ITGB4/CTNNB1/EIF2B2/CMTM8/SOD1 9 GO:0008366 axon ensheathment 9/770 136/18722 0.108465489808275 0.388492958318077 SERINC5/EPB41L3/TNFRSF21/PPARD/ITGB4/CTNNB1/EIF2B2/CMTM8/SOD1 9 GO:0043401 steroid hormone mediated signaling pathway 9/770 136/18722 0.108465489808275 0.388492958318077 DAB2/ESRRG/PGRMC2/UBR5/PPARD/EGLN2/CALR/DNAJA1/UBA5 9 GO:0002367 cytokine production involved in immune response 7/770 98/18722 0.108922652496449 0.388492958318077 PRKCZ/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36 7 GO:0003333 amino acid transmembrane transport 7/770 98/18722 0.108922652496449 0.388492958318077 SLC43A2/SLC3A2/SLC38A1/SLC38A9/SLC7A5/CLN8/SLC7A6 7 GO:1902882 regulation of response to oxidative stress 7/770 98/18722 0.108922652496449 0.388492958318077 HSPB1/P4HB/PNPLA8/CTNNB1/UBQLN1/SOD1/NFE2L2 7 GO:1904029 regulation of cyclin-dependent protein kinase activity 7/770 98/18722 0.108922652496449 0.388492958318077 CDKN1C/EGFR/HEXIM1/CEBPA/LATS2/SERTAD1/CCND3 7 GO:0000209 protein polyubiquitination 14/770 236/18722 0.109078983199787 0.388492958318077 UBE2B/OTUB2/NEDD4L/BCL2/UBE2A/HECTD1/UBR5/SKP1/TNKS2/MDM2/DDA1/DDX3X/UBE2H/CTNNB1 14 GO:0030072 peptide hormone secretion 14/770 236/18722 0.109078983199787 0.388492958318077 ANXA1/EGFR/PIM3/SERP1/SYT7/ABCG1/RAB1A/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3 14 GO:0002702 positive regulation of production of molecular mediator of immune response 8/770 117/18722 0.109363292025986 0.388492958318077 PRKCZ/TFRC/GATA3/CD55/SLC7A5/SEMA7A/DHX36/DNAJB9 8 GO:0035051 cardiocyte differentiation 10/770 156/18722 0.110094681102517 0.388492958318077 TBX3/PDCD4/EGFR/HES1/DHX36/NEBL/LMNA/CALR/SLC9A1/TGFBR3 10 GO:0022408 negative regulation of cell-cell adhesion 12/770 196/18722 0.110665323846988 0.388492958318077 ANXA1/CEBPB/ARG2/ZNF703/GLI3/SOCS1/CD274/TNFRSF21/DLG5/SPINT2/DUSP3/C1QTNF1 12 GO:0043393 regulation of protein binding 12/770 196/18722 0.110665323846988 0.388492958318077 DAB2/PHLDA2/GREM2/HOPX/APP/HDAC5/LRPAP1/GOLGA2/LRP1/CSNK1E/NRP1/TGFBR3 12 GO:0043534 blood vessel endothelial cell migration 11/770 176/18722 0.110737413878857 0.388492958318077 ANXA1/HSPB1/HMOX1/PIK3C2A/EPHB4/HDAC5/GATA2/JUP/PDPK1/NRP1/NFE2L2 11 GO:0002829 negative regulation of type 2 immune response 2/770 14/18722 0.110944488964119 0.388492958318077 ANXA1/ARG2 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/770 14/18722 0.110944488964119 0.388492958318077 ANXA6/TRIP11 2 GO:0006465 signal peptide processing 2/770 14/18722 0.110944488964119 0.388492958318077 FURIN/SEC11C 2 GO:0010896 regulation of triglyceride catabolic process 2/770 14/18722 0.110944488964119 0.388492958318077 ABHD5/PNPLA2 2 GO:0032966 negative regulation of collagen biosynthetic process 2/770 14/18722 0.110944488964119 0.388492958318077 PPARD/ERRFI1 2 GO:0034111 negative regulation of homotypic cell-cell adhesion 2/770 14/18722 0.110944488964119 0.388492958318077 ZNF703/C1QTNF1 2 GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 2/770 14/18722 0.110944488964119 0.388492958318077 GPR87/P2RY6 2 GO:0036295 cellular response to increased oxygen levels 2/770 14/18722 0.110944488964119 0.388492958318077 ATP6V1G1/ATP6V0D1 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/770 14/18722 0.110944488964119 0.388492958318077 BCL2/SOCS1 2 GO:0045837 negative regulation of membrane potential 2/770 14/18722 0.110944488964119 0.388492958318077 PMAIP1/PRELID1 2 GO:0046479 glycosphingolipid catabolic process 2/770 14/18722 0.110944488964119 0.388492958318077 NEU1/GLA 2 GO:0046655 folic acid metabolic process 2/770 14/18722 0.110944488964119 0.388492958318077 SLC19A1/MTHFS 2 GO:0048172 regulation of short-term neuronal synaptic plasticity 2/770 14/18722 0.110944488964119 0.388492958318077 CLN3/SYAP1 2 GO:0051645 Golgi localization 2/770 14/18722 0.110944488964119 0.388492958318077 HOOK3/UVRAG 2 GO:0061709 reticulophagy 2/770 14/18722 0.110944488964119 0.388492958318077 ATG2A/UBA5 2 GO:0071285 cellular response to lithium ion 2/770 14/18722 0.110944488964119 0.388492958318077 CEBPA/CALR 2 GO:0072176 nephric duct development 2/770 14/18722 0.110944488964119 0.388492958318077 GATA3/GPC3 2 GO:0072531 pyrimidine-containing compound transmembrane transport 2/770 14/18722 0.110944488964119 0.388492958318077 SLC19A2/SLC19A3 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/770 14/18722 0.110944488964119 0.388492958318077 BCL2/MIF 2 GO:1904152 regulation of retrograde protein transport, ER to cytosol 2/770 14/18722 0.110944488964119 0.388492958318077 EDEM1/ERLEC1 2 GO:0032613 interleukin-10 production 5/770 62/18722 0.111020263424632 0.388492958318077 PRKCZ/CD274/TNFRSF21/CD46/HSPD1 5 GO:0032653 regulation of interleukin-10 production 5/770 62/18722 0.111020263424632 0.388492958318077 PRKCZ/CD274/TNFRSF21/CD46/HSPD1 5 GO:0060113 inner ear receptor cell differentiation 5/770 62/18722 0.111020263424632 0.388492958318077 HES1/TRIP11/MYO6/PAFAH1B1/SOD1 5 GO:0060135 maternal process involved in female pregnancy 5/770 62/18722 0.111020263424632 0.388492958318077 AKR1B1/UBE2A/KPNA6/PPARD/BSG 5 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 5/770 62/18722 0.111020263424632 0.388492958318077 PRKCZ/RAB11A/OPHN1/GRIP1/AP2M1 5 GO:1901264 carbohydrate derivative transport 6/770 80/18722 0.111172398662899 0.388752324587526 SLC19A1/SLC25A5/ABCG1/CLN3/GLTP/SLC35B4 6 GO:0022898 regulation of transmembrane transporter activity 16/770 278/18722 0.111275637065725 0.388840462481421 TCAF1/FXYD3/NEDD4L/APP/BCL2/EHD3/AKAP9/P2RY6/KLHL24/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COX17/ACTN4 16 GO:1901617 organic hydroxy compound biosynthetic process 14/770 237/18722 0.111811238946389 0.390438264660025 HSD17B1/GATA3/AKR1B1/CYB5R1/P2RY6/ISYNA1/OPN3/ABCG1/IDI1/DDT/PDXK/OSBP/INSIG1/SOD1 14 GO:0009416 response to light stimulus 18/770 320/18722 0.11203204163594 0.390439993166002 UBE2B/EGFR/APP/RDH13/BCL2/UBE2A/MME/JUND/DHX36/ID2/OPN3/BHLHE40/NR2F6/MDM2/DDB1/MAP3K4/USP47/PPP1CB 18 GO:0016042 lipid catabolic process 18/770 320/18722 0.11203204163594 0.390439993166002 CYP19A1/ABHD5/ABHD3/STS/NEU1/PNPLA8/PPARD/IRS2/FUCA1/ACADVL/GLA/LDLR/AIG1/LRP1/PNPLA2/RAB7A/PRDX6/PAFAH1B1 18 GO:0010977 negative regulation of neuron projection development 9/770 137/18722 0.112125151559412 0.390439993166002 SEMA6A/MYLIP/SEMA7A/DIP2B/MDM2/LRP1/KANK1/NRP1/PAFAH1B1 9 GO:0055123 digestive system development 9/770 137/18722 0.112125151559412 0.390439993166002 EGFR/HES1/BCL2/LGR4/GLI3/YIPF6/ID2/SLC4A2/CTNNB1 9 GO:1903131 mononuclear cell differentiation 23/770 426/18722 0.112249264668097 0.390526831882113 ANXA1/PRKCZ/CEBPB/GATA3/CTSL/PNP/BCL2/GLI3/HDAC5/SOCS1/HECTD1/ID2/DNAJB9/NFIL3/SLC25A5/TPD52/CD46/CTNNB1/FNIP1/PRELID1/KDELR1/PBX1/SOD1 23 GO:0010824 regulation of centrosome duplication 4/770 45/18722 0.112698692403468 0.390526831882113 CHMP2B/VPS4B/CHMP4B/CHMP2A 4 GO:0030850 prostate gland development 4/770 45/18722 0.112698692403468 0.390526831882113 ANXA1/GLI3/CTNNB1/SERPINF1 4 GO:0042551 neuron maturation 4/770 45/18722 0.112698692403468 0.390526831882113 GLDN/APP/BCL2/MAP3K13 4 GO:0048546 digestive tract morphogenesis 4/770 45/18722 0.112698692403468 0.390526831882113 BCL2/GLI3/ID2/CTNNB1 4 GO:0060119 inner ear receptor cell development 4/770 45/18722 0.112698692403468 0.390526831882113 HES1/TRIP11/PAFAH1B1/SOD1 4 GO:0098534 centriole assembly 4/770 45/18722 0.112698692403468 0.390526831882113 CDK2/VPS4B/CEP152/CHMP2A 4 GO:0008154 actin polymerization or depolymerization 13/770 217/18722 0.112949164671867 0.390851171916608 RASA1/SCIN/SPIRE2/FMN1/WASL/JMY/CDC42EP4/SNX9/ARF1/RICTOR/KANK1/ARHGAP18/IQGAP2 13 GO:0070374 positive regulation of ERK1 and ERK2 cascade 13/770 217/18722 0.112949164671867 0.390851171916608 PRKCZ/EGFR/APP/BRAF/SEMA7A/RAP1B/P2RY6/DDT/LRP1/GAREM1/NRP1/MIF/FERMT2 13 GO:0042100 B cell proliferation 7/770 99/18722 0.113314264889448 0.390948549403122 TFRC/VAV3/BCL2/TNFRSF21/IRS2/MIF/HSPD1 7 GO:0022612 gland morphogenesis 8/770 118/18722 0.113358169270001 0.390948549403122 TBX3/CEBPB/BCL2/TGM2/GLI3/ELF3/KDM5B/NRP1 8 GO:0045446 endothelial cell differentiation 8/770 118/18722 0.113358169270001 0.390948549403122 EZR/BTG1/RAP1B/EDF1/RAPGEF1/CTNNB1/NRP1/RAP2C 8 GO:0022407 regulation of cell-cell adhesion 24/770 448/18722 0.113419045795753 0.390948549403122 ANXA1/PRKCZ/ST3GAL4/TFRC/CEBPB/GATA3/CD55/ARG2/ZNF703/PNP/HES1/GLI3/PLPP3/SOCS1/CD274/MYO10/TENM3/TNFRSF21/DLG5/CD46/SPINT2/DUSP3/C1QTNF1/HSPD1 24 GO:0051017 actin filament bundle assembly 10/770 157/18722 0.113526500298278 0.390948549403122 EZR/FHDC1/MTSS1/SPIRE2/PHLDB2/PPFIA1/SLC9A1/NRP1/SORBS1/FERMT2 10 GO:0051250 negative regulation of lymphocyte activation 10/770 157/18722 0.113526500298278 0.390948549403122 ANXA1/CEBPB/ARG2/GLI3/SOCS1/CD274/ID2/TNFRSF21/DLG5/DUSP3 10 GO:0070646 protein modification by small protein removal 10/770 157/18722 0.113526500298278 0.390948549403122 OTUB2/VCP/ATXN7/USP43/TANK/UBXN1/USP8/USP16/PSMD14/USP47 10 GO:0002263 cell activation involved in immune response 16/770 279/18722 0.113815688590449 0.391673740501525 ANXA1/PRKCZ/TFRC/HMOX1/GATA3/APP/DYSF/GATA2/PDPK1/CD46/SUPT6H/PI4K2A/LRP1/STXBP3/SNAP23/HSPD1 16 GO:0032103 positive regulation of response to external stimulus 23/770 427/18722 0.114294500906789 0.393050033139083 PGF/HSPB1/NUPR1/PDCD4/EGFR/CEBPB/HEXIM1/APP/SERPINE1/TGM2/NFKBIA/CEBPA/NEAT1/AKIRIN1/DDT/AKIRIN2/LDLR/LRP1/CALR/TBK1/NRP1/HSP90AA1/HSPD1 23 GO:0005979 regulation of glycogen biosynthetic process 3/770 29/18722 0.115057865276733 0.393232745318218 IRS2/SORBS1/PPP1CB 3 GO:0010390 histone monoubiquitination 3/770 29/18722 0.115057865276733 0.393232745318218 RYBP/SKP1/DDB1 3 GO:0010962 regulation of glucan biosynthetic process 3/770 29/18722 0.115057865276733 0.393232745318218 IRS2/SORBS1/PPP1CB 3 GO:0015701 bicarbonate transport 3/770 29/18722 0.115057865276733 0.393232745318218 SLC26A2/CYB5R1/SLC4A2 3 GO:0021602 cranial nerve morphogenesis 3/770 29/18722 0.115057865276733 0.393232745318218 TFAP2A/GLI3/NRP1 3 GO:0033028 myeloid cell apoptotic process 3/770 29/18722 0.115057865276733 0.393232745318218 ANXA1/CTSL/BCL2 3 GO:0060441 epithelial tube branching involved in lung morphogenesis 3/770 29/18722 0.115057865276733 0.393232745318218 DLG5/CTNNB1/RDH10 3 GO:0070979 protein K11-linked ubiquitination 3/770 29/18722 0.115057865276733 0.393232745318218 UBE2B/UBE2A/UBE2H 3 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/770 29/18722 0.115057865276733 0.393232745318218 BCL2/MIF/USP47 3 GO:0035107 appendage morphogenesis 9/770 138/18722 0.115852623749479 0.395406591879216 TBX3/TFAP2A/GLI3/FMN1/CTNNB1/DLX5/RDH10/GPC3/PBX1 9 GO:0035108 limb morphogenesis 9/770 138/18722 0.115852623749479 0.395406591879216 TBX3/TFAP2A/GLI3/FMN1/CTNNB1/DLX5/RDH10/GPC3/PBX1 9 GO:0001523 retinoid metabolic process 6/770 81/18722 0.116154017836722 0.395622331428834 AKR1B1/RDH13/PPARD/LRP1/PNPLA2/RDH10 6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 6/770 81/18722 0.116154017836722 0.395622331428834 PEG10/BCL9L/HSPA5/PDPK1/SNX6/TGFBR3 6 GO:0044773 mitotic DNA damage checkpoint signaling 6/770 81/18722 0.116154017836722 0.395622331428834 FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 6 GO:0016239 positive regulation of macroautophagy 5/770 63/18722 0.11676131745164 0.397147880451551 HSPB8/HMOX1/SLC25A5/UVRAG/TBK1 5 GO:2000756 regulation of peptidyl-lysine acetylation 5/770 63/18722 0.11676131745164 0.397147880451551 GATA3/GATA2/DIP2B/IWS1/RPS6KA5 5 GO:0010906 regulation of glucose metabolic process 8/770 119/18722 0.117431031046773 0.398881273146604 PMAIP1/PHLDA2/DDB1/IRS2/C1QTNF1/SORBS1/SLC35B4/PPP1CB 8 GO:0031398 positive regulation of protein ubiquitination 8/770 119/18722 0.117431031046773 0.398881273146604 ARRDC3/PTTG1IP/HSPA5/SKP1/DDX3X/UBQLN1/PDCD6/COMMD1 8 GO:0019218 regulation of steroid metabolic process 7/770 100/18722 0.117797670792633 0.399581888059693 CGA/ABCG1/ACADVL/LDLR/INSIG1/ADM/SOD1 7 GO:0060840 artery development 7/770 100/18722 0.117797670792633 0.399581888059693 HES1/GLI3/HECTD1/LDLR/LRP1/NRP1/ADAMTS6 7 GO:0051091 positive regulation of DNA-binding transcription factor activity 15/770 260/18722 0.118405469032435 0.40137037563852 PRKCZ/ARID5B/TFRC/APP/DDIT3/PLPP3/CD200/HDAC5/ERC1/JUP/JMY/CTNNB1/HSPA1B/RPS6KA5/MAP3K13 15 GO:0030216 keratinocyte differentiation 9/770 139/18722 0.119647448778625 0.402316195776399 ANXA1/NCOA3/DSP/GRHL1/OPN3/IRF6/NUMA1/TSG101/ERRFI1 9 GO:0001974 blood vessel remodeling 4/770 46/18722 0.119653341790211 0.402316195776399 TGM2/EPAS1/MDM2/TMBIM1 4 GO:0007019 microtubule depolymerization 4/770 46/18722 0.119653341790211 0.402316195776399 CCSAP/ATXN7/CAMSAP2/TAOK1 4 GO:0031018 endocrine pancreas development 4/770 46/18722 0.119653341790211 0.402316195776399 ANXA1/HES1/PDPK1/RHEB 4 GO:0031648 protein destabilization 4/770 46/18722 0.119653341790211 0.402316195776399 SIAH1/MYLIP/MDM2/SERF2 4 GO:0042398 cellular modified amino acid biosynthetic process 4/770 46/18722 0.119653341790211 0.402316195776399 MTHFS/CKMT1B/PTDSS1/NFE2L2 4 GO:0043462 regulation of ATPase activity 4/770 46/18722 0.119653341790211 0.402316195776399 NAPA/DNAJB1/GABARAPL2/TOR1AIP2 4 GO:0048701 embryonic cranial skeleton morphogenesis 4/770 46/18722 0.119653341790211 0.402316195776399 TFAP2A/GLI3/EIF4A3/RDH10 4 GO:0060976 coronary vasculature development 4/770 46/18722 0.119653341790211 0.402316195776399 NRP1/GPC3/TGFBR3/ADAMTS6 4 GO:0061028 establishment of endothelial barrier 4/770 46/18722 0.119653341790211 0.402316195776399 EZR/RAP1B/RAPGEF1/RAP2C 4 GO:0061462 protein localization to lysosome 4/770 46/18722 0.119653341790211 0.402316195776399 SH3BP4/ZFYVE16/RAB7A/HSPA8 4 GO:0072599 establishment of protein localization to endoplasmic reticulum 4/770 46/18722 0.119653341790211 0.402316195776399 HERPUD1/HSPA5/EDEM1/CHMP4B 4 GO:0032411 positive regulation of transporter activity 8/770 120/18722 0.121581190827148 0.405742036947182 SGK1/TCAF1/EHD3/AKAP9/P2RY6/SLC9A1/COX17/ACTN4 8 GO:0051897 positive regulation of protein kinase B signaling 8/770 120/18722 0.121581190827148 0.405742036947182 GDF15/EGFR/GATA3/C1QTNF1/RICTOR/HSP90AA1/MYDGF/FERMT2 8 GO:0097529 myeloid leukocyte migration 13/770 220/18722 0.12185705756891 0.405742036947182 ANXA1/PGF/CSF3R/VAV3/SERPINE1/MPP1/CD200/MTUS1/AKIRIN1/BSG/DDT/PPIB/MIF 13 GO:0042102 positive regulation of T cell proliferation 7/770 101/18722 0.122371827305347 0.405742036947182 ANXA1/TFRC/CD55/PNP/HES1/CD274/CD46 7 GO:0006749 glutathione metabolic process 5/770 64/18722 0.122640260323607 0.405742036947182 GSTA3/CLIC3/GSTA4/SOD1/NFE2L2 5 GO:0016126 sterol biosynthetic process 5/770 64/18722 0.122640260323607 0.405742036947182 CYB5R1/ABCG1/IDI1/INSIG1/SOD1 5 GO:0030858 positive regulation of epithelial cell differentiation 5/770 64/18722 0.122640260323607 0.405742036947182 NCOA3/SERPINE1/BTG1/NUMA1/CTNNB1 5 GO:0071902 positive regulation of protein serine/threonine kinase activity 12/770 200/18722 0.12313846344474 0.405742036947182 EGFR/GHR/ERN1/DVL3/SYAP1/DDX3X/RICTOR/MAP3K13/MAP3K4/TAOK1/FERMT2/CCND3 12 GO:0099003 vesicle-mediated transport in synapse 12/770 200/18722 0.12313846344474 0.405742036947182 RAB11A/RAP1B/OPHN1/CLCN3/GRIP1/SYT7/NAPA/CTNNB1/SYNJ1/RAB5A/SNAP23/AP2M1 12 GO:0140694 non-membrane-bounded organelle assembly 20/770 367/18722 0.123166685711373 0.405742036947182 RAB11A/PRRC2C/EZR/SBDS/NEK7/GOLGA2/DDX28/KRT8/CCSAP/GRB7/NEBL/CHMP2B/CDK2/NUMA1/DDX3X/VPS4B/HSPA1B/CEP152/CHMP4B/CHMP2A 20 GO:0015748 organophosphate ester transport 9/770 140/18722 0.123509125137198 0.405742036947182 ATP10D/KCNN4/SLC19A1/PITPNA/SLC25A5/ABCG1/GLTP/PRELID1/LDLR 9 GO:0010721 negative regulation of cell development 11/770 180/18722 0.123970451898441 0.405742036947182 SEMA6A/FBLN1/HES1/SEMA7A/HOOK3/DIP2B/CTNNB1/LDLR/KANK1/NRP1/ACTN4 11 GO:0043409 negative regulation of MAPK cascade 11/770 180/18722 0.123970451898441 0.405742036947182 PDCD4/SEMA6A/EZR/DUSP5/FBLN1/ATF3/DUSP9/DUSP3/PAFAH1B1/ERRFI1/DNAJA1 11 GO:0031571 mitotic G1 DNA damage checkpoint signaling 3/770 30/18722 0.12414410514098 0.405742036947182 MDM2/CDK2/GIGYF2 3 GO:0043032 positive regulation of macrophage activation 3/770 30/18722 0.12414410514098 0.405742036947182 JUND/CEBPA/HSPD1 3 GO:0043304 regulation of mast cell degranulation 3/770 30/18722 0.12414410514098 0.405742036947182 HMOX1/GATA2/PDPK1 3 GO:0045070 positive regulation of viral genome replication 3/770 30/18722 0.12414410514098 0.405742036947182 DDB1/DDX3X/STAU1 3 GO:0045940 positive regulation of steroid metabolic process 3/770 30/18722 0.12414410514098 0.405742036947182 CGA/ABCG1/ADM 3 GO:0051491 positive regulation of filopodium assembly 3/770 30/18722 0.12414410514098 0.405742036947182 WASL/MIEN1/NRP1 3 GO:0060351 cartilage development involved in endochondral bone morphogenesis 3/770 30/18722 0.12414410514098 0.405742036947182 ANXA6/GHR/TRIP11 3 GO:1903019 negative regulation of glycoprotein metabolic process 3/770 30/18722 0.12414410514098 0.405742036947182 BACE2/AGO2/TMEM59 3 GO:0090316 positive regulation of intracellular protein transport 10/770 160/18722 0.124178528425328 0.405742036947182 TCAF1/GLI3/JUP/LEPROT/UBR5/EDEM1/SAR1A/MDM2/SAR1B/STOM 10 GO:0002836 positive regulation of response to tumor cell 2/770 15/18722 0.124662062726497 0.405742036947182 CD274/HSPD1 2 GO:0002839 positive regulation of immune response to tumor cell 2/770 15/18722 0.124662062726497 0.405742036947182 CD274/HSPD1 2 GO:0006704 glucocorticoid biosynthetic process 2/770 15/18722 0.124662062726497 0.405742036947182 CYP11A1/HSD11B2 2 GO:0006878 cellular copper ion homeostasis 2/770 15/18722 0.124662062726497 0.405742036947182 APP/ARF1 2 GO:0010452 histone H3-K36 methylation 2/770 15/18722 0.124662062726497 0.405742036947182 IWS1/BRD4 2 GO:0010713 negative regulation of collagen metabolic process 2/770 15/18722 0.124662062726497 0.405742036947182 PPARD/ERRFI1 2 GO:0014841 skeletal muscle satellite cell proliferation 2/770 15/18722 0.124662062726497 0.405742036947182 PPARD/AKIRIN1 2 GO:0014857 regulation of skeletal muscle cell proliferation 2/770 15/18722 0.124662062726497 0.405742036947182 PPARD/AKIRIN1 2 GO:0019511 peptidyl-proline hydroxylation 2/770 15/18722 0.124662062726497 0.405742036947182 P4HB/EGLN2 2 GO:0030252 growth hormone secretion 2/770 15/18722 0.124662062726497 0.405742036947182 SERP1/RAB1A 2 GO:0032239 regulation of nucleobase-containing compound transport 2/770 15/18722 0.124662062726497 0.405742036947182 SUPT6H/IWS1 2 GO:0034638 phosphatidylcholine catabolic process 2/770 15/18722 0.124662062726497 0.405742036947182 PNPLA8/LDLR 2 GO:0042249 establishment of planar polarity of embryonic epithelium 2/770 15/18722 0.124662062726497 0.405742036947182 DVL3/PAFAH1B1 2 GO:0043508 negative regulation of JUN kinase activity 2/770 15/18722 0.124662062726497 0.405742036947182 PDCD4/DNAJA1 2 GO:0045217 cell-cell junction maintenance 2/770 15/18722 0.124662062726497 0.405742036947182 MTSS1/FERMT2 2 GO:0045725 positive regulation of glycogen biosynthetic process 2/770 15/18722 0.124662062726497 0.405742036947182 IRS2/SORBS1 2 GO:0046321 positive regulation of fatty acid oxidation 2/770 15/18722 0.124662062726497 0.405742036947182 PPARD/IRS2 2 GO:0048308 organelle inheritance 2/770 15/18722 0.124662062726497 0.405742036947182 GOLGA2/STX5 2 GO:0048313 Golgi inheritance 2/770 15/18722 0.124662062726497 0.405742036947182 GOLGA2/STX5 2 GO:0060049 regulation of protein glycosylation 2/770 15/18722 0.124662062726497 0.405742036947182 GOLGA2/TMEM59 2 GO:0086069 bundle of His cell to Purkinje myocyte communication 2/770 15/18722 0.124662062726497 0.405742036947182 DSP/JUP 2 GO:0099170 postsynaptic modulation of chemical synaptic transmission 2/770 15/18722 0.124662062726497 0.405742036947182 EIF4A3/USP8 2 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/770 15/18722 0.124662062726497 0.405742036947182 DNAJB9/HSPA5 2 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/770 15/18722 0.124662062726497 0.405742036947182 DHX36/AGO2 2 GO:1903729 regulation of plasma membrane organization 2/770 15/18722 0.124662062726497 0.405742036947182 WASL/PLEKHM2 2 GO:1990822 basic amino acid transmembrane transport 2/770 15/18722 0.124662062726497 0.405742036947182 SLC38A9/SLC7A6 2 GO:2000402 negative regulation of lymphocyte migration 2/770 15/18722 0.124662062726497 0.405742036947182 CD200/WASL 2 GO:0003206 cardiac chamber morphogenesis 8/770 121/18722 0.125807904510913 0.409204169828903 TBX3/GATA3/DSP/HES1/MDM2/PPP1R13L/NRP1/TGFBR3 8 GO:0002790 peptide secretion 14/770 242/18722 0.126075442254676 0.409425602529177 ANXA1/EGFR/PIM3/SERP1/SYT7/ABCG1/RAB1A/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3 14 GO:0010639 negative regulation of organelle organization 19/770 347/18722 0.126200596208455 0.409425602529177 TFRC/NUPR1/SCIN/SLC25A5/LIMK2/ATXN7/PHLDB2/PPFIA1/TNKS2/LMNA/XRN1/FEZ2/PRELID1/RAB7A/KANK1/CAMSAP2/CHMP4B/GHITM/TAOK1 19 GO:0051054 positive regulation of DNA metabolic process 12/770 201/18722 0.126376084668043 0.409425602529177 TFRC/UBE2B/EGFR/SPIRE2/NEK7/DHX36/PKIB/TNKS2/PPP1R10/CTNNB1/MAP3K4/HSP90AA1 12 GO:0031397 negative regulation of protein ubiquitination 6/770 83/18722 0.126445910467552 0.409425602529177 SQSTM1/OTUB2/UBR5/HSPA1B/UBXN1/DNAJA1 6 GO:0046785 microtubule polymerization 6/770 83/18722 0.126445910467552 0.409425602529177 CLIP1/GOLGA2/AKAP9/NUMA1/HSPA1B/CAMSAP2 6 GO:0003018 vascular process in circulatory system 15/770 263/18722 0.126750050982194 0.409425602529177 TFRC/SLC2A1/PIK3C2A/EGFR/SLC38A1/SLC19A1/SLC7A5/SLC5A6/PPARD/LRP1/ADM/SLC13A3/SLC44A1/SOD1/FERMT2 15 GO:0010761 fibroblast migration 4/770 47/18722 0.126788051981332 0.409425602529177 ARID5B/GNA12/CLN3/ZFAND5 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/770 47/18722 0.126788051981332 0.409425602529177 GATA3/BASP1/MTSS1/CTNNB1 4 GO:0047496 vesicle transport along microtubule 4/770 47/18722 0.126788051981332 0.409425602529177 PRKCZ/CLN3/RAB1A/PAFAH1B1 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/770 47/18722 0.126788051981332 0.409425602529177 ARRDC3/DDIT3/LGR4/RHEB 4 GO:1900744 regulation of p38MAPK cascade 4/770 47/18722 0.126788051981332 0.409425602529177 GADD45G/EZR/PHLPP1/MAP3K4 4 GO:1901987 regulation of cell cycle phase transition 21/770 390/18722 0.12699765620593 0.409425602529177 ANXA1/EGFR/NABP1/RAB11A/OVOL1/APP/BCL2/ID2/FOXO4/MDM2/DDB1/CDK2/DDX3X/PPP1R10/GIGYF2/VPS4B/BRD4/PBX1/USP47/TAOK1/CCND3 21 GO:0001841 neural tube formation 7/770 102/18722 0.127035613233182 0.409425602529177 SPINT1/HECTD1/MIB1/DVL3/SPINT2/BRD2/ADM 7 GO:0006672 ceramide metabolic process 7/770 102/18722 0.127035613233182 0.409425602529177 SPTSSA/PLPP3/SAMD8/NEU1/CLN8/GLA/ORMDL1 7 GO:0006119 oxidative phosphorylation 9/770 141/18722 0.127437108071995 0.409425602529177 NUPR1/NDUFA6/VCP/COX6C/COX4I1/GHITM/COX7B/COX6A1/NDUFB9 9 GO:0008584 male gonad development 9/770 141/18722 0.127437108071995 0.409425602529177 ARID5B/NUPR1/GATA3/SDC1/BCL2/TBC1D20/EIF2S2/ADGRG1/RHOBTB3 9 GO:0016571 histone methylation 9/770 141/18722 0.127437108071995 0.409425602529177 GATA3/KMT2C/TET2/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/BRD4 9 GO:0032355 response to estradiol 9/770 141/18722 0.127437108071995 0.409425602529177 CYP19A1/ANXA1/EGFR/NCOA3/ZNF703/MBD3/CTNNB1/LCOR/CALR 9 GO:1903038 negative regulation of leukocyte cell-cell adhesion 9/770 141/18722 0.127437108071995 0.409425602529177 ANXA1/CEBPB/ARG2/GLI3/SOCS1/CD274/TNFRSF21/DLG5/DUSP3 9 GO:0061572 actin filament bundle organization 10/770 161/18722 0.127846822642268 0.410384864691245 EZR/FHDC1/MTSS1/SPIRE2/PHLDB2/PPFIA1/SLC9A1/NRP1/SORBS1/FERMT2 10 GO:0050900 leukocyte migration 20/770 369/18722 0.127900400334237 0.410384864691245 ANXA1/PGF/ST3GAL4/HMOX1/CSF3R/GATA3/VAV3/APP/SERPINE1/MPP1/SBDS/CD200/WASL/MTUS1/AKIRIN1/BSG/DDT/PPIB/CALR/MIF 20 GO:0015909 long-chain fatty acid transport 5/770 65/18722 0.128654019558001 0.412007056206632 ANXA1/SLC2A1/PLIN2/PNPLA8/IRS2 5 GO:0046503 glycerolipid catabolic process 5/770 65/18722 0.128654019558001 0.412007056206632 ABHD5/PNPLA8/LDLR/PNPLA2/PRDX6 5 GO:0070613 regulation of protein processing 5/770 65/18722 0.128654019558001 0.412007056206632 SERPINE1/CLN3/MDM2/TMEM59/CAST 5 GO:0043543 protein acylation 14/770 243/18722 0.12904797549677 0.41300325105999 NUPR1/GATA3/NCOA3/CDYL/MBD3/GATA2/DIP2B/GTF2B/ZDHHC3/DDX3X/ZDHHC20/IWS1/RPS6KA5/TAOK1 14 GO:0015833 peptide transport 15/770 264/18722 0.129605161868898 0.414520232087752 ANXA1/EGFR/PIM3/SERP1/SYT7/ABCG1/RAB1A/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SLC13A3 15 GO:0048562 embryonic organ morphogenesis 16/770 285/18722 0.12977944743659 0.414811408965061 TBX3/GATA3/TFAP2A/HES1/GLI3/GATA2/ID2/MIB1/CTNNB1/DLX5/EIF4A3/MYO6/RDH10/INSIG1/EFEMP1/SOD1 16 GO:0009314 response to radiation 24/770 456/18722 0.130090775094543 0.415336311281731 ANXA1/UBE2B/EGFR/GATA3/NABP1/APP/RDH13/BCL2/UBE2A/MME/JUND/DHX36/ID2/HSPA5/OPN3/BHLHE40/NR2F6/MDM2/DDB1/TANK/MAP3K4/SWI5/USP47/PPP1CB 24 GO:0002688 regulation of leukocyte chemotaxis 8/770 122/18722 0.130110371645752 0.415336311281731 PGF/SERPINE1/MPP1/MTUS1/AKIRIN1/DDT/CALR/MIF 8 GO:0050920 regulation of chemotaxis 13/770 223/18722 0.131155792030339 0.418405449223545 PGF/HSPB1/SEMA6A/SERPINE1/MPP1/SEMA7A/MTUS1/AKIRIN1/DUSP3/DDT/CALR/NRP1/MIF 13 GO:0046546 development of primary male sexual characteristics 9/770 142/18722 0.131430810298188 0.418546057212867 ARID5B/NUPR1/GATA3/SDC1/BCL2/TBC1D20/EIF2S2/ADGRG1/RHOBTB3 9 GO:2000045 regulation of G1/S transition of mitotic cell cycle 9/770 142/18722 0.131430810298188 0.418546057212867 ANXA1/EGFR/BCL2/ID2/MDM2/CDK2/DDX3X/GIGYF2/CCND3 9 GO:0034250 positive regulation of cellular amide metabolic process 10/770 162/18722 0.131573222706592 0.418546057212867 EIF4G2/SERP1/DHX36/ABCG1/LARP4B/DDX3X/EIF4A3/AGO2/USP16/NFE2L2 10 GO:0006835 dicarboxylic acid transport 6/770 84/18722 0.131752578024906 0.418546057212867 SLC26A2/KMO/SLC19A2/SLC19A1/CLN8/SLC13A3 6 GO:0010660 regulation of muscle cell apoptotic process 6/770 84/18722 0.131752578024906 0.418546057212867 NUPR1/HMOX1/PDCD4/PDPK1/PPP1R10/NFE2L2 6 GO:0032370 positive regulation of lipid transport 6/770 84/18722 0.131752578024906 0.418546057212867 CYP19A1/NFKBIA/ABCG1/C1QTNF1/PRELID1/LRP1 6 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 7/770 103/18722 0.13178783138009 0.418546057212867 AKR1B1/HES1/GHR/SOCS1/LEPROT/IL10RB/PRLR 7 GO:0007159 leukocyte cell-cell adhesion 20/770 371/18722 0.132740761646883 0.420968537655524 ANXA1/PRKCZ/ST3GAL4/TFRC/CEBPB/GATA3/CD55/ARG2/EZR/PNP/HES1/GLI3/SOCS1/CD274/OLR1/TNFRSF21/DLG5/CD46/DUSP3/HSPD1 20 GO:0006643 membrane lipid metabolic process 12/770 203/18722 0.13299285057835 0.420968537655524 ST3GAL4/B3GNT5/SPTSSA/SERINC5/PLPP3/SAMD8/NEU1/GLTP/CLN8/FUCA1/GLA/ORMDL1 12 GO:0001516 prostaglandin biosynthetic process 3/770 31/18722 0.133479889523525 0.420968537655524 ANXA1/PNPLA8/MIF 3 GO:0021988 olfactory lobe development 3/770 31/18722 0.133479889523525 0.420968537655524 SEMA7A/ID2/DLX5 3 GO:0031114 regulation of microtubule depolymerization 3/770 31/18722 0.133479889523525 0.420968537655524 ATXN7/CAMSAP2/TAOK1 3 GO:0033006 regulation of mast cell activation involved in immune response 3/770 31/18722 0.133479889523525 0.420968537655524 HMOX1/GATA2/PDPK1 3 GO:0044819 mitotic G1/S transition checkpoint signaling 3/770 31/18722 0.133479889523525 0.420968537655524 MDM2/CDK2/GIGYF2 3 GO:0046457 prostanoid biosynthetic process 3/770 31/18722 0.133479889523525 0.420968537655524 ANXA1/PNPLA8/MIF 3 GO:0048384 retinoic acid receptor signaling pathway 3/770 31/18722 0.133479889523525 0.420968537655524 ESRRG/CALR/ACTN4 3 GO:0048710 regulation of astrocyte differentiation 3/770 31/18722 0.133479889523525 0.420968537655524 HES1/ID2/LDLR 3 GO:0090183 regulation of kidney development 3/770 31/18722 0.133479889523525 0.420968537655524 GATA3/BASP1/LGR4 3 GO:0043303 mast cell degranulation 4/770 48/18722 0.13409661917885 0.422112099411378 HMOX1/GATA2/PDPK1/SNAP23 4 GO:0090199 regulation of release of cytochrome c from mitochondria 4/770 48/18722 0.13409661917885 0.422112099411378 PMAIP1/LMNA/PRELID1/GHITM 4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 4/770 48/18722 0.13409661917885 0.422112099411378 PMAIP1/ATF3/DEDD2/PDIA3 4 GO:0010811 positive regulation of cell-substrate adhesion 8/770 123/18722 0.134487736707769 0.422988198665977 PRKCZ/FMN1/JUP/P4HB/CALR/UTRN/NRP1/FERMT2 8 GO:0030193 regulation of blood coagulation 5/770 66/18722 0.134799369753476 0.422988198665977 ST3GAL4/SERPINB2/SERPINE1/C1QTNF1/NFE2L2 5 GO:0045600 positive regulation of fat cell differentiation 5/770 66/18722 0.134799369753476 0.422988198665977 CEBPB/ID2/CEBPA/PPARD/SYAP1 5 GO:0046626 regulation of insulin receptor signaling pathway 5/770 66/18722 0.134799369753476 0.422988198665977 PRKCZ/SOCS1/KANK1/SORBS1/CCND3 5 GO:0050766 positive regulation of phagocytosis 5/770 66/18722 0.134799369753476 0.422988198665977 GATA2/LMAN2/LRP1/CALR/SOD1 5 GO:0072331 signal transduction by p53 class mediator 10/770 163/18722 0.13535725725467 0.424471499622416 NUPR1/SGK1/PMAIP1/HEXIM1/PTTG1IP/BCL2/JMY/MDM2/MYO6/MIF 10 GO:0045621 positive regulation of lymphocyte differentiation 7/770 104/18722 0.136627210921337 0.424967127348944 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/CD46 7 GO:0044774 mitotic DNA integrity checkpoint signaling 6/770 85/18722 0.137163814614703 0.424967127348944 FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 6 GO:0097006 regulation of plasma lipoprotein particle levels 6/770 85/18722 0.137163814614703 0.424967127348944 HMOX1/MYLIP/LRPAP1/ABCG1/ARF1/LDLR 6 GO:0016485 protein processing 13/770 225/18722 0.137569369501207 0.424967127348944 CPM/BACE2/CTSL/SERPINE1/GLI3/MME/FURIN/CLN3/MDM2/SEC11C/ENPEP/TMEM59/CAST 13 GO:0055001 muscle cell development 11/770 184/18722 0.138042095753352 0.424967127348944 TBX3/SDC1/HES1/BCL2/DYSF/KRT8/NEBL/LMNA/ADM/ACTN4/MYOF 11 GO:0032412 regulation of ion transmembrane transporter activity 15/770 267/18722 0.138389222936771 0.424967127348944 TCAF1/FXYD3/NEDD4L/APP/EHD3/AKAP9/P2RY6/KLHL24/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COX17/ACTN4 15 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/770 16/18722 0.138756073890574 0.424967127348944 MME/ENPEP 2 GO:0002713 negative regulation of B cell mediated immunity 2/770 16/18722 0.138756073890574 0.424967127348944 CD55/CD46 2 GO:0002830 positive regulation of type 2 immune response 2/770 16/18722 0.138756073890574 0.424967127348944 PRKCZ/GATA3 2 GO:0002890 negative regulation of immunoglobulin mediated immune response 2/770 16/18722 0.138756073890574 0.424967127348944 CD55/CD46 2 GO:0009415 response to water 2/770 16/18722 0.138756073890574 0.424967127348944 AKR1B1/KRT8 2 GO:0010225 response to UV-C 2/770 16/18722 0.138756073890574 0.424967127348944 MDM2/MAP3K4 2 GO:0032274 gonadotropin secretion 2/770 16/18722 0.138756073890574 0.424967127348944 CGA/TBX3 2 GO:0035751 regulation of lysosomal lumen pH 2/770 16/18722 0.138756073890574 0.424967127348944 CLN3/TMEM106B 2 GO:0042574 retinal metabolic process 2/770 16/18722 0.138756073890574 0.424967127348944 RDH13/RDH10 2 GO:0044804 autophagy of nucleus 2/770 16/18722 0.138756073890574 0.424967127348944 ATG9B/ATG2A 2 GO:0048557 embryonic digestive tract morphogenesis 2/770 16/18722 0.138756073890574 0.424967127348944 GLI3/ID2 2 GO:0050884 neuromuscular process controlling posture 2/770 16/18722 0.138756073890574 0.424967127348944 TMEM150C/CLN8 2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 2/770 16/18722 0.138756073890574 0.424967127348944 FURIN/SNX9 2 GO:0060572 morphogenesis of an epithelial bud 2/770 16/18722 0.138756073890574 0.424967127348944 CTNNB1/RDH10 2 GO:0061548 ganglion development 2/770 16/18722 0.138756073890574 0.424967127348944 CTNNB1/NRP1 2 GO:0061684 chaperone-mediated autophagy 2/770 16/18722 0.138756073890574 0.424967127348944 HSP90AA1/HSPA8 2 GO:0070365 hepatocyte differentiation 2/770 16/18722 0.138756073890574 0.424967127348944 ANXA1/KRT18 2 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 2/770 16/18722 0.138756073890574 0.424967127348944 NFKBIA/HSPA1B 2 GO:0072283 metanephric renal vesicle morphogenesis 2/770 16/18722 0.138756073890574 0.424967127348944 FMN1/CTNNB1 2 GO:0097284 hepatocyte apoptotic process 2/770 16/18722 0.138756073890574 0.424967127348944 KRT18/KRT8 2 GO:0098884 postsynaptic neurotransmitter receptor internalization 2/770 16/18722 0.138756073890574 0.424967127348944 OPHN1/AP2M1 2 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/770 16/18722 0.138756073890574 0.424967127348944 RAB11A/GRIP1 2 GO:0099010 modification of postsynaptic structure 2/770 16/18722 0.138756073890574 0.424967127348944 CHMP2B/STAU1 2 GO:0140239 postsynaptic endocytosis 2/770 16/18722 0.138756073890574 0.424967127348944 OPHN1/AP2M1 2 GO:1901163 regulation of trophoblast cell migration 2/770 16/18722 0.138756073890574 0.424967127348944 CALR/AGO2 2 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/770 16/18722 0.138756073890574 0.424967127348944 BCL2/MIF 2 GO:1902306 negative regulation of sodium ion transmembrane transport 2/770 16/18722 0.138756073890574 0.424967127348944 NEDD4L/COMMD1 2 GO:1904948 midbrain dopaminergic neuron differentiation 2/770 16/18722 0.138756073890574 0.424967127348944 CTNNB1/CSNK1E 2 GO:1905906 regulation of amyloid fibril formation 2/770 16/18722 0.138756073890574 0.424967127348944 APP/LDLR 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/770 16/18722 0.138756073890574 0.424967127348944 DAB2/GPC3 2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 2/770 16/18722 0.138756073890574 0.424967127348944 SLC9A1/ACTN4 2 GO:2000765 regulation of cytoplasmic translation 2/770 16/18722 0.138756073890574 0.424967127348944 CPEB4/DHX36 2 GO:0010508 positive regulation of autophagy 8/770 124/18722 0.13893909043979 0.425266270062329 HSPB8/HMOX1/PIK3C2A/SH3BP4/SLC25A5/UVRAG/TBK1/TMEM59 8 GO:0002700 regulation of production of molecular mediator of immune response 10/770 164/18722 0.139198422650029 0.425798489911047 PRKCZ/TFRC/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36/DNAJB9/SUPT6H 10 GO:0071214 cellular response to abiotic stimulus 18/770 331/18722 0.139758620897409 0.426987865071607 SLC2A1/EGFR/GATA3/AKR1B1/MME/DHX36/TMEM150C/HSPA5/OPN3/CLN3/MDM2/DDB1/DDX3X/TANK/SLC9A1/ERRFI1/SWI5/USP47 18 GO:0104004 cellular response to environmental stimulus 18/770 331/18722 0.139758620897409 0.426987865071607 SLC2A1/EGFR/GATA3/AKR1B1/MME/DHX36/TMEM150C/HSPA5/OPN3/CLN3/MDM2/DDB1/DDX3X/TANK/SLC9A1/ERRFI1/SWI5/USP47 18 GO:0032409 regulation of transporter activity 17/770 310/18722 0.140542009816024 0.427031768774617 SGK1/TCAF1/FXYD3/NEDD4L/APP/BCL2/EHD3/AKAP9/P2RY6/KLHL24/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COX17/ACTN4 17 GO:0006486 protein glycosylation 13/770 226/18722 0.140839753541155 0.427031768774617 ST3GAL4/B3GNT5/MAN1A2/C1GALT1/GOLGA2/SERP1/TUSC3/TET2/TRIP11/MAN1C1/RPN2/TMEM59/DDOST 13 GO:0043413 macromolecule glycosylation 13/770 226/18722 0.140839753541155 0.427031768774617 ST3GAL4/B3GNT5/MAN1A2/C1GALT1/GOLGA2/SERP1/TUSC3/TET2/TRIP11/MAN1C1/RPN2/TMEM59/DDOST 13 GO:0035914 skeletal muscle cell differentiation 5/770 67/18722 0.141072942886497 0.427031768774617 NUPR1/MAFF/ATF3/AKIRIN1/HMG20B 5 GO:0042130 negative regulation of T cell proliferation 5/770 67/18722 0.141072942886497 0.427031768774617 CEBPB/ARG2/CD274/TNFRSF21/DLG5 5 GO:0042490 mechanoreceptor differentiation 5/770 67/18722 0.141072942886497 0.427031768774617 HES1/TRIP11/MYO6/PAFAH1B1/SOD1 5 GO:0072665 protein localization to vacuole 5/770 67/18722 0.141072942886497 0.427031768774617 SH3BP4/ZFYVE16/VPS37A/RAB7A/HSPA8 5 GO:1903317 regulation of protein maturation 5/770 67/18722 0.141072942886497 0.427031768774617 SERPINE1/CLN3/MDM2/TMEM59/CAST 5 GO:0031098 stress-activated protein kinase signaling cascade 14/770 247/18722 0.141331440484709 0.427031768774617 GADD45G/PDCD4/EGFR/EZR/APP/AKR1B1/DUSP9/DUSP3/MAP3K13/PHLPP1/MAP3K4/PAFAH1B1/DNAJA1/TAOK1 14 GO:0001894 tissue homeostasis 15/770 268/18722 0.141389585762958 0.427031768774617 HSPB1/TFRC/SLC2A1/EGFR/AKR1B1/BCL2/EPAS1/GATA2/CLCN3/CLN8/CTNNB1/GIGYF2/CHMP4B/LSR/SOD1 15 GO:0002279 mast cell activation involved in immune response 4/770 49/18722 0.141572643390662 0.427031768774617 HMOX1/GATA2/PDPK1/SNAP23 4 GO:0006692 prostanoid metabolic process 4/770 49/18722 0.141572643390662 0.427031768774617 ANXA1/AKR1B1/PNPLA8/MIF 4 GO:0006693 prostaglandin metabolic process 4/770 49/18722 0.141572643390662 0.427031768774617 ANXA1/AKR1B1/PNPLA8/MIF 4 GO:0008038 neuron recognition 4/770 49/18722 0.141572643390662 0.427031768774617 APP/TNFRSF21/BSG/NRP1 4 GO:0043330 response to exogenous dsRNA 4/770 49/18722 0.141572643390662 0.427031768774617 SLC3A2/NFKBIA/DHX36/COLEC12 4 GO:0046605 regulation of centrosome cycle 4/770 49/18722 0.141572643390662 0.427031768774617 CHMP2B/VPS4B/CHMP4B/CHMP2A 4 GO:0051932 synaptic transmission, GABAergic 4/770 49/18722 0.141572643390662 0.427031768774617 GABRE/CLCN3/CLN3/ZDHHC3 4 GO:0072091 regulation of stem cell proliferation 4/770 49/18722 0.141572643390662 0.427031768774617 TBX3/OVOL1/FBLN1/FERMT2 4 GO:0072666 establishment of protein localization to vacuole 4/770 49/18722 0.141572643390662 0.427031768774617 ZFYVE16/VPS37A/RAB7A/HSPA8 4 GO:1901799 negative regulation of proteasomal protein catabolic process 4/770 49/18722 0.141572643390662 0.427031768774617 RYBP/OPHN1/GABARAPL2/UBXN1 4 GO:1904752 regulation of vascular associated smooth muscle cell migration 4/770 49/18722 0.141572643390662 0.427031768774617 GNA12/MDM2/LRP1/NFE2L2 4 GO:0051896 regulation of protein kinase B signaling 11/770 185/18722 0.141688410210067 0.427092956908786 GDF15/EGFR/GATA3/DDIT3/C1QTNF1/RICTOR/PHLPP1/HSP90AA1/PDCD6/MYDGF/FERMT2 11 GO:0015908 fatty acid transport 6/770 86/18722 0.142677562591445 0.427092956908786 ANXA1/SLC2A1/PLIN2/PNPLA8/PPARD/IRS2 6 GO:0018108 peptidyl-tyrosine phosphorylation 20/770 375/18722 0.142739162655837 0.427092956908786 PRKCZ/EGFR/APP/EPHB4/HES1/GHR/SOCS1/ERBB3/MVP/SCYL1/RICTOR/TSG101/PRLR/SNX6/OSBP/NRP1/MIF/RAP2C/ERRFI1/EFEMP1 20 GO:0009954 proximal/distal pattern formation 3/770 32/18722 0.143049999012796 0.427092956908786 GLI3/CTNNB1/PBX1 3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 3/770 32/18722 0.143049999012796 0.427092956908786 DAB2/CDKN1C/TGFBR3 3 GO:0035883 enteroendocrine cell differentiation 3/770 32/18722 0.143049999012796 0.427092956908786 HES1/PDPK1/RHEB 3 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 3/770 32/18722 0.143049999012796 0.427092956908786 ANXA1/PRKCZ/SOCS1 3 GO:0045684 positive regulation of epidermis development 3/770 32/18722 0.143049999012796 0.427092956908786 NCOA3/PPARD/NUMA1 3 GO:0045761 regulation of adenylate cyclase activity 3/770 32/18722 0.143049999012796 0.427092956908786 GPR87/AKAP9/CAP2 3 GO:0045879 negative regulation of smoothened signaling pathway 3/770 32/18722 0.143049999012796 0.427092956908786 GLI3/VCP/GPC3 3 GO:0046475 glycerophospholipid catabolic process 3/770 32/18722 0.143049999012796 0.427092956908786 PNPLA8/LDLR/PRDX6 3 GO:0048841 regulation of axon extension involved in axon guidance 3/770 32/18722 0.143049999012796 0.427092956908786 SEMA6A/SEMA7A/NRP1 3 GO:0050685 positive regulation of mRNA processing 3/770 32/18722 0.143049999012796 0.427092956908786 DHX36/PRDX6/HSPA8 3 GO:0060317 cardiac epithelial to mesenchymal transition 3/770 32/18722 0.143049999012796 0.427092956908786 TBX3/PDCD4/TGFBR3 3 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/770 32/18722 0.143049999012796 0.427092956908786 PMAIP1/DDIT3/HERPUD1 3 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 3/770 32/18722 0.143049999012796 0.427092956908786 DAB2/CDKN1C/TGFBR3 3 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3/770 32/18722 0.143049999012796 0.427092956908786 ANXA1/ARG2/CD274 3 GO:0017038 protein import 12/770 206/18722 0.143267398893543 0.427485897417081 PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/LMNA/PPP1R10/HSP90AA1/TNPO1/HSPA8/HSPD1 12 GO:0033002 muscle cell proliferation 14/770 248/18722 0.144499586714435 0.43090451262599 HMOX1/PDCD4/EGFR/AKR1B1/GNA12/TGM2/ERN1/P2RY6/ID2/PPARD/MDM2/AKIRIN1/CTNNB1/TGFBR3 14 GO:0031345 negative regulation of cell projection organization 11/770 186/18722 0.145385255286284 0.433286320030834 SEMA6A/MYLIP/SEMA7A/ARHGAP24/DIP2B/LIMK2/MDM2/LRP1/KANK1/NRP1/PAFAH1B1 11 GO:0001824 blastocyst development 7/770 106/18722 0.146562017488339 0.434972324683975 HOPX/UBE2A/SBDS/ELF3/PSMC4/FURIN/SUPT6H 7 GO:0002062 chondrocyte differentiation 7/770 106/18722 0.146562017488339 0.434972324683975 SCIN/ANXA6/GLI3/CREB3L2/TRIP11/CTNNB1/EFEMP1 7 GO:0030038 contractile actin filament bundle assembly 7/770 106/18722 0.146562017488339 0.434972324683975 FHDC1/PHLDB2/PPFIA1/SLC9A1/NRP1/SORBS1/FERMT2 7 GO:0035821 modulation of process of other organism 7/770 106/18722 0.146562017488339 0.434972324683975 RAB9A/SERPINB9/TBC1D20/PPIB/PSMC3/STOM/HSPA8 7 GO:0043149 stress fiber assembly 7/770 106/18722 0.146562017488339 0.434972324683975 FHDC1/PHLDB2/PPFIA1/SLC9A1/NRP1/SORBS1/FERMT2 7 GO:0046620 regulation of organ growth 7/770 106/18722 0.146562017488339 0.434972324683975 CGA/BASP1/DUSP9/SERP1/LATS2/TGFBR3/SOD1 7 GO:2000278 regulation of DNA biosynthetic process 7/770 106/18722 0.146562017488339 0.434972324683975 NEK7/PKIB/TNKS2/XRN1/CTNNB1/MAP3K4/HSP90AA1 7 GO:0034394 protein localization to cell surface 5/770 68/18722 0.147471238559756 0.436890119942489 RAB11A/NEDD4L/LEPROT/CTNNB1/COMMD1 5 GO:0060411 cardiac septum morphogenesis 5/770 68/18722 0.147471238559756 0.436890119942489 TBX3/HES1/MDM2/NRP1/TGFBR3 5 GO:1900046 regulation of hemostasis 5/770 68/18722 0.147471238559756 0.436890119942489 ST3GAL4/SERPINB2/SERPINE1/C1QTNF1/NFE2L2 5 GO:0007043 cell-cell junction assembly 9/770 146/18722 0.148049621282355 0.43759330687006 ZNF703/EPB41L3/CLDN7/JUP/DLG5/CTNNB1/LSR/MPP7/CLDN4 9 GO:0045580 regulation of T cell differentiation 9/770 146/18722 0.148049621282355 0.43759330687006 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/CD46/PRELID1/SOD1 9 GO:0048813 dendrite morphogenesis 9/770 146/18722 0.148049621282355 0.43759330687006 NEDD4L/DHX36/WASL/RAB21/NRP1/CUX1/PAFAH1B1/CDKL5/TMEM106B 9 GO:2001235 positive regulation of apoptotic signaling pathway 8/770 126/18722 0.148059866623103 0.43759330687006 NUPR1/SIAH1/PMAIP1/ATF3/DDIT3/DEDD2/PDIA3/SOD1 8 GO:1900182 positive regulation of protein localization to nucleus 6/770 87/18722 0.148291671040954 0.438018611023754 TFRC/GLI3/JUP/UBR5/LIMK2/FERMT2 6 GO:0008089 anterograde axonal transport 4/770 50/18722 0.149209553591724 0.438649678789122 HSPB1/ARL8B/RAB21/SOD1 4 GO:0010665 regulation of cardiac muscle cell apoptotic process 4/770 50/18722 0.149209553591724 0.438649678789122 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0018023 peptidyl-lysine trimethylation 4/770 50/18722 0.149209553591724 0.438649678789122 TET2/LMNA/IWS1/BRD4 4 GO:0042572 retinol metabolic process 4/770 50/18722 0.149209553591724 0.438649678789122 AKR1B1/RDH13/PNPLA2/RDH10 4 GO:0045058 T cell selection 4/770 50/18722 0.149209553591724 0.438649678789122 GATA3/CTSL/BCL2/GLI3 4 GO:0060425 lung morphogenesis 4/770 50/18722 0.149209553591724 0.438649678789122 STK40/DLG5/CTNNB1/RDH10 4 GO:0090102 cochlea development 4/770 50/18722 0.149209553591724 0.438649678789122 GATA3/HES1/GATA2/PAFAH1B1 4 GO:1904738 vascular associated smooth muscle cell migration 4/770 50/18722 0.149209553591724 0.438649678789122 GNA12/MDM2/LRP1/NFE2L2 4 GO:0010632 regulation of epithelial cell migration 16/770 292/18722 0.149948069468489 0.439411843026142 ANXA1/HSPB1/HMOX1/PIK3C2A/GATA3/RAB11A/PLPP3/HDAC5/GATA2/JUP/PDPK1/CALR/NRP1/SERPINF1/PDCD6/NFE2L2 16 GO:0018212 peptidyl-tyrosine modification 20/770 378/18722 0.150513128619939 0.439411843026142 PRKCZ/EGFR/APP/EPHB4/HES1/GHR/SOCS1/ERBB3/MVP/SCYL1/RICTOR/TSG101/PRLR/SNX6/OSBP/NRP1/MIF/RAP2C/ERRFI1/EFEMP1 20 GO:0042110 T cell activation 25/770 487/18722 0.150746486818779 0.439411843026142 ANXA1/PRKCZ/TFRC/CEBPB/GATA3/CD55/CTSL/ARG2/PNP/HES1/BCL2/GLI3/SOCS1/CD274/TNFRSF21/DLG5/CD46/DUSP3/CTNNB1/PRELID1/KDELR1/DDOST/SOD1/HSPD1/CCND3 25 GO:0071695 anatomical structure maturation 13/770 229/18722 0.150901889593823 0.439411843026142 GLDN/GATA3/APP/AKR1B1/HES1/BCL2/DDIT3/EPAS1/PHOSPHO1/GATA2/CEBPA/CTNNB1/MAP3K13 13 GO:0034767 positive regulation of ion transmembrane transport 10/770 167/18722 0.151059194601202 0.439411843026142 TCAF1/KCNN4/EHD3/AKAP9/P2RY6/PDPK1/ARF1/SLC9A1/COX17/ACTN4 10 GO:0007229 integrin-mediated signaling pathway 7/770 107/18722 0.151654557060798 0.439411843026142 VAV3/CD63/PLPP3/SEMA7A/ITGB4/NRP1/FERMT2 7 GO:0010927 cellular component assembly involved in morphogenesis 7/770 107/18722 0.151654557060798 0.439411843026142 EPB41L3/KRT8/PHLDB2/TBC1D20/NEBL/ITGB4/PAFAH1B1 7 GO:0031532 actin cytoskeleton reorganization 7/770 107/18722 0.151654557060798 0.439411843026142 ANXA1/THSD7A/EZR/RICTOR/NRP1/NRK/IQGAP2 7 GO:0006605 protein targeting 17/770 314/18722 0.151940731536607 0.439411843026142 TCAF1/HERPUD1/HSPA5/LEPROT/EDEM1/ZDHHC3/ZFAND6/ZDHHC20/SIL1/ZFYVE16/VPS37A/RAB7A/CHMP4B/HSP90AA1/STOM/HSPA8/HSPD1 17 GO:0060249 anatomical structure homeostasis 17/770 314/18722 0.151940731536607 0.439411843026142 HSPB1/TFRC/SLC2A1/EGFR/AKR1B1/BCL2/EPAS1/GATA2/CLCN3/CLN8/CHMP2B/CTNNB1/GIGYF2/CHMP4B/LSR/TAOK1/SOD1 17 GO:1903531 negative regulation of secretion by cell 9/770 147/18722 0.15236167726195 0.439411843026142 ANXA1/HMOX1/PIM3/CD200/RAP1B/VPS4B/RAB7A/STXBP3/RAB11FIP1 9 GO:0042558 pteridine-containing compound metabolic process 3/770 33/18722 0.152839195224743 0.439411843026142 SLC19A1/GGH/MTHFS 3 GO:0046320 regulation of fatty acid oxidation 3/770 33/18722 0.152839195224743 0.439411843026142 PPARD/IRS2/ACADVL 3 GO:0060122 inner ear receptor cell stereocilium organization 3/770 33/18722 0.152839195224743 0.439411843026142 HES1/TRIP11/SOD1 3 GO:0071353 cellular response to interleukin-4 3/770 33/18722 0.152839195224743 0.439411843026142 GATA3/HSPA5/NFIL3 3 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 3/770 33/18722 0.152839195224743 0.439411843026142 ARHGAP24/LIMK2/KANK1 3 GO:1901099 negative regulation of signal transduction in absence of ligand 3/770 33/18722 0.152839195224743 0.439411843026142 BCL2/IFI6/HSPA1B 3 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 3/770 33/18722 0.152839195224743 0.439411843026142 BCL2/IFI6/HSPA1B 3 GO:0001675 acrosome assembly 2/770 17/18722 0.153172460633436 0.439411843026142 TBC1D20/PAFAH1B1 2 GO:0007351 tripartite regional subdivision 2/770 17/18722 0.153172460633436 0.439411843026142 TBX3/BASP1 2 GO:0008595 anterior/posterior axis specification, embryo 2/770 17/18722 0.153172460633436 0.439411843026142 TBX3/BASP1 2 GO:0010224 response to UV-B 2/770 17/18722 0.153172460633436 0.439411843026142 BCL2/MME 2 GO:0010612 regulation of cardiac muscle adaptation 2/770 17/18722 0.153172460633436 0.439411843026142 LMNA/ERRFI1 2 GO:0014856 skeletal muscle cell proliferation 2/770 17/18722 0.153172460633436 0.439411843026142 PPARD/AKIRIN1 2 GO:0020027 hemoglobin metabolic process 2/770 17/18722 0.153172460633436 0.439411843026142 ALAS1/EIF2AK1 2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 2/770 17/18722 0.153172460633436 0.439411843026142 LEPROT/CHMP4B 2 GO:0033623 regulation of integrin activation 2/770 17/18722 0.153172460633436 0.439411843026142 RAP1B/FERMT2 2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 2/770 17/18722 0.153172460633436 0.439411843026142 PIK3C2A/SYNJ1 2 GO:0044539 long-chain fatty acid import into cell 2/770 17/18722 0.153172460633436 0.439411843026142 SLC2A1/IRS2 2 GO:0045591 positive regulation of regulatory T cell differentiation 2/770 17/18722 0.153172460633436 0.439411843026142 SOCS1/CD46 2 GO:0060977 coronary vasculature morphogenesis 2/770 17/18722 0.153172460633436 0.439411843026142 NRP1/TGFBR3 2 GO:0070293 renal absorption 2/770 17/18722 0.153172460633436 0.439411843026142 SGK1/CLDN4 2 GO:0070875 positive regulation of glycogen metabolic process 2/770 17/18722 0.153172460633436 0.439411843026142 IRS2/SORBS1 2 GO:0090136 epithelial cell-cell adhesion 2/770 17/18722 0.153172460633436 0.439411843026142 DSP/JUP 2 GO:0090399 replicative senescence 2/770 17/18722 0.153172460633436 0.439411843026142 SERPINE1/MME 2 GO:0140354 lipid import into cell 2/770 17/18722 0.153172460633436 0.439411843026142 SLC2A1/IRS2 2 GO:1900034 regulation of cellular response to heat 2/770 17/18722 0.153172460633436 0.439411843026142 DNAJB1/DNAJB6 2 GO:1902358 sulfate transmembrane transport 2/770 17/18722 0.153172460633436 0.439411843026142 SLC26A2/SLC13A4 2 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 2/770 17/18722 0.153172460633436 0.439411843026142 LMNA/ERRFI1 2 GO:1903540 establishment of protein localization to postsynaptic membrane 2/770 17/18722 0.153172460633436 0.439411843026142 RAB11A/GRIP1 2 GO:1903830 magnesium ion transmembrane transport 2/770 17/18722 0.153172460633436 0.439411843026142 CNNM2/TUSC3 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/770 17/18722 0.153172460633436 0.439411843026142 GATA3/CTNNB1 2 GO:1903037 regulation of leukocyte cell-cell adhesion 18/770 336/18722 0.153547520958755 0.440234348065291 ANXA1/PRKCZ/ST3GAL4/TFRC/CEBPB/GATA3/CD55/ARG2/PNP/HES1/GLI3/SOCS1/CD274/TNFRSF21/DLG5/CD46/DUSP3/HSPD1 18 GO:0050810 regulation of steroid biosynthetic process 5/770 69/18722 0.153990634172232 0.441035308574559 CGA/ABCG1/INSIG1/ADM/SOD1 5 GO:0001843 neural tube closure 6/770 88/18722 0.154003900646143 0.441035308574559 SPINT1/HECTD1/DVL3/SPINT2/BRD2/ADM 6 GO:0043484 regulation of RNA splicing 9/770 148/18722 0.156735080783515 0.448329025196186 MBNL3/SAP18/ERN1/HNRNPH2/RBM8A/RBM42/SRSF5/PRDX6/HSPA8 9 GO:1903900 regulation of viral life cycle 9/770 148/18722 0.156735080783515 0.448329025196186 BCL2/KPNA6/P4HB/CHMP2B/DDB1/DDX3X/TSG101/STAU1/CHMP2A 9 GO:0021872 forebrain generation of neurons 4/770 51/18722 0.157000631942072 0.448329025196186 HES1/GLI3/GATA2/NRP1 4 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 4/770 51/18722 0.157000631942072 0.448329025196186 ANXA1/PRKCZ/GATA3/SOCS1 4 GO:0046850 regulation of bone remodeling 4/770 51/18722 0.157000631942072 0.448329025196186 TFRC/EGFR/SYT7/SUCO 4 GO:0044772 mitotic cell cycle phase transition 22/770 424/18722 0.157131471520504 0.448445660129823 ANXA1/EGFR/NABP1/RAB11A/APP/BCL2/ID2/LATS2/FOXO4/MDM2/DDB1/CDK2/DDX3X/GIGYF2/VPS4B/BRD4/CHMP4B/PBX1/USP47/TAOK1/CHMP2A/CCND3 22 GO:0045017 glycerolipid biosynthetic process 14/770 252/18722 0.157553870631735 0.44925076509928 PIK3C2A/ABHD5/ABHD3/SOCS1/CLN3/TTC7B/SH3YL1/LDLR/PI4K2A/SYNJ1/PNPLA2/PTDSS1/SLC44A1/TMEM150A 14 GO:0009306 protein secretion 19/770 359/18722 0.157593886693466 0.44925076509928 ANXA1/EGFR/EZR/KCNN4/PIM3/CD200/SERP1/SYT7/ABCG1/PPARD/ARF1/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/PAFAH1B1/RAB11FIP1 19 GO:0006417 regulation of translation 24/770 468/18722 0.157708031048265 0.44931910732619 HSPB1/SECISBP2L/EIF4G2/EIF1/APP/ETF1/EIF2AK1/CPEB4/EIF5/PAIP2/SERP1/DHX36/GRB7/LARP4B/RBM8A/XRN1/DDX3X/GIGYF2/CALR/EIF4A3/EIF2B2/EIF4H/AGO2/USP16 24 GO:0010657 muscle cell apoptotic process 6/770 89/18722 0.159811928585703 0.454793169698776 NUPR1/HMOX1/PDCD4/PDPK1/PPP1R10/NFE2L2 6 GO:0060606 tube closure 6/770 89/18722 0.159811928585703 0.454793169698776 SPINT1/HECTD1/DVL3/SPINT2/BRD2/ADM 6 GO:0035592 establishment of protein localization to extracellular region 19/770 360/18722 0.160388173185005 0.45617252681557 ANXA1/EGFR/EZR/KCNN4/PIM3/CD200/SERP1/SYT7/ABCG1/PPARD/ARF1/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/PAFAH1B1/RAB11FIP1 19 GO:0099111 microtubule-based transport 11/770 190/18722 0.160668385220206 0.456708821193547 PRKCZ/HSPB1/APP/ARL8B/CLN3/RAB1A/RAB21/ARMCX3/PAFAH1B1/HSPA8/SOD1 11 GO:0009743 response to carbohydrate 14/770 253/18722 0.160911449372206 0.456878491294417 PIM3/ERN1/KRT18/RAP1B/ABCG1/PPARD/IRS2/DYNLL1/LRP1/COLEC12/OSBP/CCDC186/EIF2B2/SERPINF1 14 GO:0097305 response to alcohol 14/770 253/18722 0.160911449372206 0.456878491294417 FDX1/GATA3/GNAI1/GRAMD1C/GGH/P2RY6/JUP/MDM2/XRN1/CTNNB1/CDO1/TGFBR3/PSMD14/SOD1 14 GO:0032368 regulation of lipid transport 9/770 149/18722 0.161168970193283 0.457349076579232 CYP19A1/NFKBIA/FURIN/ABCG1/IRS2/KDM5B/C1QTNF1/PRELID1/LRP1 9 GO:0046474 glycerophospholipid biosynthetic process 12/770 211/18722 0.161299945447508 0.457460232307872 PIK3C2A/ABHD5/ABHD3/SOCS1/CLN3/TTC7B/SH3YL1/PI4K2A/SYNJ1/PTDSS1/SLC44A1/TMEM150A 12 GO:0032414 positive regulation of ion transmembrane transporter activity 7/770 109/18722 0.162082210190062 0.458932841983941 TCAF1/EHD3/AKAP9/P2RY6/SLC9A1/COX17/ACTN4 7 GO:0007616 long-term memory 3/770 34/18722 0.162832282686656 0.458932841983941 PRKCZ/SGK1/LDLR 3 GO:0014072 response to isoquinoline alkaloid 3/770 34/18722 0.162832282686656 0.458932841983941 MAP1LC3A/GHR/MDM2 3 GO:0034383 low-density lipoprotein particle clearance 3/770 34/18722 0.162832282686656 0.458932841983941 HMOX1/MYLIP/LDLR 3 GO:0043278 response to morphine 3/770 34/18722 0.162832282686656 0.458932841983941 MAP1LC3A/GHR/MDM2 3 GO:0044319 wound healing, spreading of cells 3/770 34/18722 0.162832282686656 0.458932841983941 ARHGAP24/PHLDB2/FERMT2 3 GO:0050931 pigment cell differentiation 3/770 34/18722 0.162832282686656 0.458932841983941 CD63/BCL2/GLI3 3 GO:0070050 neuron cellular homeostasis 3/770 34/18722 0.162832282686656 0.458932841983941 CLCN3/CHMP2B/TAOK1 3 GO:0086004 regulation of cardiac muscle cell contraction 3/770 34/18722 0.162832282686656 0.458932841983941 DSP/AKAP9/JUP 3 GO:0090505 epiboly involved in wound healing 3/770 34/18722 0.162832282686656 0.458932841983941 ARHGAP24/PHLDB2/FERMT2 3 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/770 34/18722 0.162832282686656 0.458932841983941 GATA3/DIP2B/RPS6KA5 3 GO:0050821 protein stabilization 11/770 191/18722 0.164610505186605 0.463559628619606 UBE2B/AAK1/PLPP3/DVL3/BAG1/RAB21/PPIB/HSPA1B/CALR/HSP90AA1/HSPD1 11 GO:0010662 regulation of striated muscle cell apoptotic process 4/770 52/18722 0.164939037034429 0.463559628619606 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0043090 amino acid import 4/770 52/18722 0.164939037034429 0.463559628619606 SLC43A2/SLC3A2/SLC7A5/CLN8 4 GO:0043277 apoptotic cell clearance 4/770 52/18722 0.164939037034429 0.463559628619606 ANXA1/RHOBTB1/TGM2/LRP1 4 GO:0043392 negative regulation of DNA binding 4/770 52/18722 0.164939037034429 0.463559628619606 HMOX1/DDIT3/NFKBIA/MSX2 4 GO:0034644 cellular response to UV 6/770 90/18722 0.16571335345238 0.463664727671703 MME/DHX36/OPN3/MDM2/DDB1/USP47 6 GO:0046849 bone remodeling 6/770 90/18722 0.16571335345238 0.463664727671703 TFRC/EGFR/LGR4/SYT7/CTNNB1/SUCO 6 GO:0099175 regulation of postsynapse organization 6/770 90/18722 0.16571335345238 0.463664727671703 DHX36/ARF4/CHMP2B/PAFAH1B1/CDKL5/HSPA8 6 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 6/770 90/18722 0.16571335345238 0.463664727671703 HMOX1/PDCD4/GNA12/ERN1/P2RY6/MDM2 6 GO:0010959 regulation of metal ion transport 21/770 406/18722 0.167229686256098 0.463664727671703 FXYD3/NEDD4L/KCNN4/CD63/BCL2/EHD3/AKAP9/P2RY6/KLHL24/PRSS8/PDPK1/MLLT6/ARF1/CTNNB1/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COMMD1/ACTN4 21 GO:0008344 adult locomotory behavior 5/770 71/18722 0.16737768404449 0.463664727671703 APP/CLCN3/CLN8/GIGYF2/PAFAH1B1 5 GO:0050818 regulation of coagulation 5/770 71/18722 0.16737768404449 0.463664727671703 ST3GAL4/SERPINB2/SERPINE1/C1QTNF1/NFE2L2 5 GO:1905954 positive regulation of lipid localization 7/770 110/18722 0.167414063522725 0.463664727671703 CYP19A1/NFKBIA/ABCG1/PLIN2/C1QTNF1/PRELID1/LRP1 7 GO:0051048 negative regulation of secretion 10/770 171/18722 0.167637414813789 0.463664727671703 ANXA1/HMOX1/PIM3/CD200/RAP1B/ERBB3/VPS4B/RAB7A/STXBP3/RAB11FIP1 10 GO:0002643 regulation of tolerance induction 2/770 18/18722 0.167860961011389 0.463664727671703 CD274/PHLPP1 2 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 2/770 18/18722 0.167860961011389 0.463664727671703 CD55/CD46 2 GO:0008272 sulfate transport 2/770 18/18722 0.167860961011389 0.463664727671703 SLC26A2/SLC13A4 2 GO:0010985 negative regulation of lipoprotein particle clearance 2/770 18/18722 0.167860961011389 0.463664727671703 MYLIP/LRPAP1 2 GO:0015693 magnesium ion transport 2/770 18/18722 0.167860961011389 0.463664727671703 CNNM2/TUSC3 2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 2/770 18/18722 0.167860961011389 0.463664727671703 PRKCZ/GATA3 2 GO:0043116 negative regulation of vascular permeability 2/770 18/18722 0.167860961011389 0.463664727671703 ADM/FERMT2 2 GO:0043217 myelin maintenance 2/770 18/18722 0.167860961011389 0.463664727671703 EPB41L3/SOD1 2 GO:0044872 lipoprotein localization 2/770 18/18722 0.167860961011389 0.463664727671703 ZDHHC3/LRP1 2 GO:0045116 protein neddylation 2/770 18/18722 0.167860961011389 0.463664727671703 EPAS1/UBE2M 2 GO:0045956 positive regulation of calcium ion-dependent exocytosis 2/770 18/18722 0.167860961011389 0.463664727671703 SYT7/ARF1 2 GO:0048643 positive regulation of skeletal muscle tissue development 2/770 18/18722 0.167860961011389 0.463664727671703 BCL2/CTNNB1 2 GO:0051895 negative regulation of focal adhesion assembly 2/770 18/18722 0.167860961011389 0.463664727671703 PHLDB2/LRP1 2 GO:0072079 nephron tubule formation 2/770 18/18722 0.167860961011389 0.463664727671703 GATA3/CTNNB1 2 GO:0072234 metanephric nephron tubule development 2/770 18/18722 0.167860961011389 0.463664727671703 HES1/LGR4 2 GO:0098877 neurotransmitter receptor transport to plasma membrane 2/770 18/18722 0.167860961011389 0.463664727671703 RAB11A/GRIP1 2 GO:0099558 maintenance of synapse structure 2/770 18/18722 0.167860961011389 0.463664727671703 ERC1/OPHN1 2 GO:0150079 negative regulation of neuroinflammatory response 2/770 18/18722 0.167860961011389 0.463664727671703 CD200/LDLR 2 GO:0150118 negative regulation of cell-substrate junction organization 2/770 18/18722 0.167860961011389 0.463664727671703 PHLDB2/LRP1 2 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/770 18/18722 0.167860961011389 0.463664727671703 DHX36/AGO2 2 GO:1902001 fatty acid transmembrane transport 2/770 18/18722 0.167860961011389 0.463664727671703 SLC2A1/IRS2 2 GO:1902683 regulation of receptor localization to synapse 2/770 18/18722 0.167860961011389 0.463664727671703 PRKCZ/ZDHHC3 2 GO:0032872 regulation of stress-activated MAPK cascade 11/770 192/18722 0.168600038330911 0.465448194461458 GADD45G/PDCD4/EGFR/EZR/APP/DUSP3/PHLPP1/MAP3K4/PAFAH1B1/DNAJA1/TAOK1 11 GO:0001505 regulation of neurotransmitter levels 12/770 213/18722 0.168821250493648 0.465800825697591 KMO/SLC38A1/RAP1B/SYT7/CLN3/NAPA/CLN8/MAOA/SYNJ1/RAB5A/STXBP3/SNAP23 12 GO:0045765 regulation of angiogenesis 18/770 342/18722 0.171040603964288 0.471634479055973 PGF/HSPB1/HMOX1/SEMA6A/SERPINE1/BTG1/GATA2/JUP/FOXO4/PDPK1/CTNNB1/NRP1/AGO2/SERPINF1/PDCD6/ADM/MYDGF/NFE2L2 18 GO:0090596 sensory organ morphogenesis 14/770 256/18722 0.171204765405585 0.471634479055973 GATA3/TFAP2A/RDH13/BCL2/GLI3/GATA2/TENM3/TBC1D20/CTNNB1/DLX5/MYO6/INSIG1/EFEMP1/SOD1 14 GO:0002065 columnar/cuboidal epithelial cell differentiation 6/770 91/18722 0.17170570017819 0.471634479055973 CEBPB/SERPINE1/HES1/YIPF6/PDPK1/RHEB 6 GO:1990874 vascular associated smooth muscle cell proliferation 6/770 91/18722 0.17170570017819 0.471634479055973 HMOX1/PDCD4/GNA12/ERN1/P2RY6/MDM2 6 GO:0042770 signal transduction in response to DNA damage 10/770 172/18722 0.171913807834849 0.471634479055973 PMAIP1/PTTG1IP/FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/MYO6/MIF/TAOK1 10 GO:0006612 protein targeting to membrane 8/770 131/18722 0.17208325300086 0.471634479055973 TCAF1/HSPA5/ZDHHC3/ZDHHC20/SIL1/VPS37A/CHMP4B/STOM 8 GO:0007020 microtubule nucleation 3/770 35/18722 0.173014164264688 0.471634479055973 GOLGA2/AKAP9/HSPA1B 3 GO:0015695 organic cation transport 3/770 35/18722 0.173014164264688 0.471634479055973 SLC19A2/SLC19A3/SLC44A1 3 GO:0018149 peptide cross-linking 3/770 35/18722 0.173014164264688 0.471634479055973 ANXA1/DSP/TGM2 3 GO:0031076 embryonic camera-type eye development 3/770 35/18722 0.173014164264688 0.471634479055973 TFAP2A/PPP1R13L/RDH10 3 GO:0032350 regulation of hormone metabolic process 3/770 35/18722 0.173014164264688 0.471634479055973 GATA3/RDH10/ADM 3 GO:0046627 negative regulation of insulin receptor signaling pathway 3/770 35/18722 0.173014164264688 0.471634479055973 PRKCZ/SOCS1/KANK1 3 GO:0046640 regulation of alpha-beta T cell proliferation 3/770 35/18722 0.173014164264688 0.471634479055973 CD55/ARG2/CD274 3 GO:0071108 protein K48-linked deubiquitination 3/770 35/18722 0.173014164264688 0.471634479055973 OTUB2/UBXN1/USP8 3 GO:0086005 ventricular cardiac muscle cell action potential 3/770 35/18722 0.173014164264688 0.471634479055973 NEDD4L/DSP/JUP 3 GO:0090504 epiboly 3/770 35/18722 0.173014164264688 0.471634479055973 ARHGAP24/PHLDB2/FERMT2 3 GO:1905508 protein localization to microtubule organizing center 3/770 35/18722 0.173014164264688 0.471634479055973 GOLGB1/HOOK3/NUMA1 3 GO:0001541 ovarian follicle development 4/770 53/18722 0.17301782615178 0.471634479055973 CEBPB/BCL2/EIF2B2/SOD1 4 GO:0016925 protein sumoylation 4/770 53/18722 0.17301782615178 0.471634479055973 MDM2/CTNNB1/HMG20B/UBE2I 4 GO:0031279 regulation of cyclase activity 4/770 53/18722 0.17301782615178 0.471634479055973 GNAS/GPR87/AKAP9/CAP2 4 GO:0033059 cellular pigmentation 4/770 53/18722 0.17301782615178 0.471634479055973 RAB11A/CD63/BCL2/RAB1A 4 GO:0034381 plasma lipoprotein particle clearance 4/770 53/18722 0.17301782615178 0.471634479055973 HMOX1/MYLIP/LRPAP1/LDLR 4 GO:0005977 glycogen metabolic process 5/770 72/18722 0.174237571978729 0.473922391468345 PHLDA2/STK40/IRS2/SORBS1/PPP1CB 5 GO:0030330 DNA damage response, signal transduction by p53 class mediator 5/770 72/18722 0.174237571978729 0.473922391468345 PMAIP1/PTTG1IP/MDM2/MYO6/MIF 5 GO:0043903 regulation of biological process involved in symbiotic interaction 5/770 72/18722 0.174237571978729 0.473922391468345 P4HB/CHMP2B/DDB1/TSG101/CHMP2A 5 GO:0071479 cellular response to ionizing radiation 5/770 72/18722 0.174237571978729 0.473922391468345 GATA3/HSPA5/MDM2/TANK/SWI5 5 GO:0005996 monosaccharide metabolic process 14/770 257/18722 0.174708245133106 0.474741168791514 PMAIP1/SLC2A1/PHLDA2/ATF3/AKR1B1/SERP1/PPARD/DDB1/IRS2/FUCA1/C1QTNF1/SORBS1/SLC35B4/PPP1CB 14 GO:0021915 neural tube development 9/770 152/18722 0.174824411947106 0.474741168791514 SPINT1/HES1/GLI3/HECTD1/MIB1/DVL3/SPINT2/BRD2/ADM 9 GO:0030509 BMP signaling pathway 9/770 152/18722 0.174824411947106 0.474741168791514 GDF15/PDCD4/GREM2/HES1/CRIM1/NUMA1/DLX5/GPC3/TGFBR3 9 GO:0090068 positive regulation of cell cycle process 13/770 236/18722 0.175800885091039 0.477132794340222 ANXA1/UBE2B/EGFR/RAB11A/APP/MDM2/NUMA1/DDX3X/PPP1R10/VPS4B/BRD4/PBX1/CCND3 13 GO:0035249 synaptic transmission, glutamatergic 6/770 92/18722 0.17778642495451 0.482258985056245 KMO/EGFR/OPHN1/CLCN3/CLN3/NAPA 6 GO:0048640 negative regulation of developmental growth 7/770 112/18722 0.178305253842247 0.483140337083151 CGA/GDF15/SEMA6A/SPAG9/SEMA7A/DIP2B/NRP1 7 GO:1901222 regulation of NIK/NF-kappaB signaling 7/770 112/18722 0.178305253842247 0.483140337083151 PDCD4/EGFR/APP/NFKBIA/DDX3X/CALR/ACTN4 7 GO:0120254 olefinic compound metabolic process 9/770 153/18722 0.179490935357155 0.48588870280889 HSD17B1/CYP11A1/CYP2J2/AKR1B1/RDH13/PNPLA8/PNPLA2/RDH10/ADM 9 GO:0019318 hexose metabolic process 13/770 237/18722 0.179514569911934 0.48588870280889 PMAIP1/PHLDA2/ATF3/AKR1B1/SERP1/PPARD/DDB1/IRS2/FUCA1/C1QTNF1/SORBS1/SLC35B4/PPP1CB 13 GO:0021700 developmental maturation 15/770 280/18722 0.180122449768353 0.48628641029655 GLDN/GATA3/APP/AKR1B1/CD63/HES1/BCL2/DDIT3/EPAS1/PHOSPHO1/GATA2/CLCN3/CEBPA/CTNNB1/MAP3K13 15 GO:0050870 positive regulation of T cell activation 12/770 216/18722 0.180421638432503 0.48628641029655 ANXA1/PRKCZ/TFRC/GATA3/CD55/PNP/HES1/GLI3/SOCS1/CD274/CD46/HSPD1 12 GO:0045619 regulation of lymphocyte differentiation 10/770 174/18722 0.180619522335201 0.48628641029655 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/ID2/CD46/PRELID1/SOD1 10 GO:0070302 regulation of stress-activated protein kinase signaling cascade 11/770 195/18722 0.180847002857922 0.48628641029655 GADD45G/PDCD4/EGFR/EZR/APP/DUSP3/PHLPP1/MAP3K4/PAFAH1B1/DNAJA1/TAOK1 11 GO:0006073 cellular glucan metabolic process 5/770 73/18722 0.181203046581063 0.48628641029655 PHLDA2/STK40/IRS2/SORBS1/PPP1CB 5 GO:0044042 glucan metabolic process 5/770 73/18722 0.181203046581063 0.48628641029655 PHLDA2/STK40/IRS2/SORBS1/PPP1CB 5 GO:0086003 cardiac muscle cell contraction 5/770 73/18722 0.181203046581063 0.48628641029655 NEDD4L/DSP/AKAP9/JUP/SLC9A1 5 GO:0006584 catecholamine metabolic process 4/770 54/18722 0.181229976522019 0.48628641029655 GATA3/AKR1B1/EPAS1/MAOA 4 GO:0009712 catechol-containing compound metabolic process 4/770 54/18722 0.181229976522019 0.48628641029655 GATA3/AKR1B1/EPAS1/MAOA 4 GO:0010659 cardiac muscle cell apoptotic process 4/770 54/18722 0.181229976522019 0.48628641029655 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0032330 regulation of chondrocyte differentiation 4/770 54/18722 0.181229976522019 0.48628641029655 SCIN/GLI3/CTNNB1/EFEMP1 4 GO:0035065 regulation of histone acetylation 4/770 54/18722 0.181229976522019 0.48628641029655 GATA3/GATA2/IWS1/RPS6KA5 4 GO:0010565 regulation of cellular ketone metabolic process 8/770 133/18722 0.182156010644571 0.48628641029655 ANXA1/CLN3/PPARD/IRS2/ACADVL/RDH10/INSIG1/ADM 8 GO:0002902 regulation of B cell apoptotic process 2/770 19/18722 0.182774892507708 0.48628641029655 IRS2/FNIP1 2 GO:0006491 N-glycan processing 2/770 19/18722 0.182774892507708 0.48628641029655 MAN1A2/MAN1C1 2 GO:0008356 asymmetric cell division 2/770 19/18722 0.182774892507708 0.48628641029655 GOLGA2/TEAD3 2 GO:0010885 regulation of cholesterol storage 2/770 19/18722 0.182774892507708 0.48628641029655 ABCG1/PPARD 2 GO:0030011 maintenance of cell polarity 2/770 19/18722 0.182774892507708 0.48628641029655 DLG5/SLC9A1 2 GO:0043031 negative regulation of macrophage activation 2/770 19/18722 0.182774892507708 0.48628641029655 CD200/LDLR 2 GO:0045019 negative regulation of nitric oxide biosynthetic process 2/770 19/18722 0.182774892507708 0.48628641029655 GLA/DYNLL1 2 GO:0045603 positive regulation of endothelial cell differentiation 2/770 19/18722 0.182774892507708 0.48628641029655 BTG1/CTNNB1 2 GO:0045618 positive regulation of keratinocyte differentiation 2/770 19/18722 0.182774892507708 0.48628641029655 NCOA3/NUMA1 2 GO:0045780 positive regulation of bone resorption 2/770 19/18722 0.182774892507708 0.48628641029655 TFRC/EGFR 2 GO:0046794 transport of virus 2/770 19/18722 0.182774892507708 0.48628641029655 CTSL/KPNA6 2 GO:0060065 uterus development 2/770 19/18722 0.182774892507708 0.48628641029655 GATA3/KDM5B 2 GO:0060216 definitive hemopoiesis 2/770 19/18722 0.182774892507708 0.48628641029655 GATA2/TGFBR3 2 GO:0070734 histone H3-K27 methylation 2/770 19/18722 0.182774892507708 0.48628641029655 GATA3/SUPT6H 2 GO:0072077 renal vesicle morphogenesis 2/770 19/18722 0.182774892507708 0.48628641029655 FMN1/CTNNB1 2 GO:1900221 regulation of amyloid-beta clearance 2/770 19/18722 0.182774892507708 0.48628641029655 LRPAP1/LRP1 2 GO:1904406 negative regulation of nitric oxide metabolic process 2/770 19/18722 0.182774892507708 0.48628641029655 GLA/DYNLL1 2 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 2/770 19/18722 0.182774892507708 0.48628641029655 SOCS1/CD274 2 GO:0008207 C21-steroid hormone metabolic process 3/770 36/18722 0.183369890617543 0.48628641029655 CYP11A1/AKR1B1/ADM 3 GO:0046466 membrane lipid catabolic process 3/770 36/18722 0.183369890617543 0.48628641029655 NEU1/FUCA1/GLA 3 GO:0070670 response to interleukin-4 3/770 36/18722 0.183369890617543 0.48628641029655 GATA3/HSPA5/NFIL3 3 GO:0090322 regulation of superoxide metabolic process 3/770 36/18722 0.183369890617543 0.48628641029655 EGFR/SOD1/NFE2L2 3 GO:1901658 glycosyl compound catabolic process 3/770 36/18722 0.183369890617543 0.48628641029655 PNP/FUCA1/GLA 3 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/770 36/18722 0.183369890617543 0.48628641029655 BCL2/MIF/USP47 3 GO:1903539 protein localization to postsynaptic membrane 3/770 36/18722 0.183369890617543 0.48628641029655 PRKCZ/RAB11A/GRIP1 3 GO:0071692 protein localization to extracellular region 19/770 368/18722 0.183691307322958 0.486879672548031 ANXA1/EGFR/EZR/KCNN4/PIM3/CD200/SERP1/SYT7/ABCG1/PPARD/ARF1/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/PAFAH1B1/RAB11FIP1 19 GO:0006006 glucose metabolic process 11/770 196/18722 0.18501996755587 0.489952367712859 PMAIP1/PHLDA2/ATF3/SERP1/PPARD/DDB1/IRS2/C1QTNF1/SORBS1/SLC35B4/PPP1CB 11 GO:0022900 electron transport chain 10/770 175/18722 0.185047231795224 0.489952367712859 CYP19A1/FDX1/AKR1B1/NDUFA6/COX6C/COX4I1/GHITM/COX7B/COX6A1/NDUFB9 10 GO:0051403 stress-activated MAPK cascade 13/770 239/18722 0.187055074296152 0.494480336985531 GADD45G/PDCD4/EGFR/EZR/APP/DUSP9/DUSP3/MAP3K13/PHLPP1/MAP3K4/PAFAH1B1/DNAJA1/TAOK1 13 GO:0072593 reactive oxygen species metabolic process 13/770 239/18722 0.187055074296152 0.494480336985531 PMAIP1/EGFR/GPX3/ARG2/TFAP2A/BCL2/IFI6/ARF4/CLCN3/PRDX6/SOD1/NFE2L2/HSPD1 13 GO:1903039 positive regulation of leukocyte cell-cell adhesion 13/770 239/18722 0.187055074296152 0.494480336985531 ANXA1/PRKCZ/ST3GAL4/TFRC/GATA3/CD55/PNP/HES1/GLI3/SOCS1/CD274/CD46/HSPD1 13 GO:0042552 myelination 8/770 134/18722 0.187286474507013 0.494829534712857 SERINC5/EPB41L3/TNFRSF21/ITGB4/CTNNB1/EIF2B2/CMTM8/SOD1 8 GO:0003151 outflow tract morphogenesis 5/770 74/18722 0.188270022226906 0.497164557899666 TBX3/HES1/CTNNB1/NRP1/TGFBR3 5 GO:0006606 protein import into nucleus 9/770 155/18722 0.188989925321563 0.497954330479724 PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/LMNA/PPP1R10/TNPO1 9 GO:0006665 sphingolipid metabolic process 9/770 155/18722 0.188989925321563 0.497954330479724 SPTSSA/SERINC5/PLPP3/SAMD8/NEU1/GLTP/CLN8/GLA/ORMDL1 9 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7/770 114/18722 0.189487728509215 0.497954330479724 GDF15/DAB2/CDKN1C/HES1/NUMA1/GPC3/TGFBR3 7 GO:1904892 regulation of receptor signaling pathway via STAT 7/770 114/18722 0.189487728509215 0.497954330479724 AKR1B1/HES1/GHR/SOCS1/LEPROT/IL10RB/PRLR 7 GO:1901342 regulation of vasculature development 18/770 348/18722 0.189527505840256 0.497954330479724 PGF/HSPB1/HMOX1/SEMA6A/SERPINE1/BTG1/GATA2/JUP/FOXO4/PDPK1/CTNNB1/NRP1/AGO2/SERPINF1/PDCD6/ADM/MYDGF/NFE2L2 18 GO:0001755 neural crest cell migration 4/770 55/18722 0.189568405562921 0.497954330479724 SEMA6A/ANXA6/SEMA7A/NRP1 4 GO:0038066 p38MAPK cascade 4/770 55/18722 0.189568405562921 0.497954330479724 GADD45G/EZR/PHLPP1/MAP3K4 4 GO:0042220 response to cocaine 4/770 55/18722 0.189568405562921 0.497954330479724 TGM2/HSPA5/MDM2/HSPD1 4 GO:0045620 negative regulation of lymphocyte differentiation 4/770 55/18722 0.189568405562921 0.497954330479724 ANXA1/GLI3/SOCS1/ID2 4 GO:0098900 regulation of action potential 4/770 55/18722 0.189568405562921 0.497954330479724 DSP/AKAP9/JUP/SLC9A1 4 GO:0046486 glycerolipid metabolic process 20/770 392/18722 0.189804651777027 0.498312212752857 PIK3C2A/MTMR10/SERINC5/ABHD5/ABHD3/SOCS1/CLN3/TTC7B/SH3YL1/PNPLA8/LDLR/PI4K2A/SYNJ1/PNPLA2/INSIG1/PRDX6/PAFAH1B1/PTDSS1/SLC44A1/TMEM150A 20 GO:0001738 morphogenesis of a polarized epithelium 6/770 94/18722 0.190202519115142 0.498831133026712 DAB2/OPHN1/DVL3/DLG5/GPC3/PAFAH1B1 6 GO:0014020 primary neural tube formation 6/770 94/18722 0.190202519115142 0.498831133026712 SPINT1/HECTD1/DVL3/SPINT2/BRD2/ADM 6 GO:0044262 cellular carbohydrate metabolic process 15/770 283/18722 0.190559090336431 0.499240771370366 NUPR1/PMAIP1/PHLDA2/AKR1B1/BRAF/STK40/P2RY6/ISYNA1/DDB1/IRS2/C1QTNF1/SYNJ1/SORBS1/SLC35B4/PPP1CB 15 GO:0051146 striated muscle cell differentiation 15/770 283/18722 0.190559090336431 0.499240771370366 ERVFRD-1/GDF15/TBX3/ERVW-1/HOPX/SPAG9/SDC1/BCL2/HDAC5/KRT8/NEBL/LMNA/CALR/SLC9A1/MYOF 15 GO:0070085 glycosylation 13/770 240/18722 0.190880936170351 0.499821179683058 ST3GAL4/B3GNT5/MAN1A2/C1GALT1/GOLGA2/SERP1/TUSC3/TET2/TRIP11/MAN1C1/RPN2/TMEM59/DDOST 13 GO:0009746 response to hexose 12/770 219/18722 0.192391318591109 0.500387174821631 PIM3/ERN1/KRT18/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/EIF2B2/SERPINF1 12 GO:2001020 regulation of response to DNA damage stimulus 12/770 219/18722 0.192391318591109 0.500387174821631 PMAIP1/EGFR/OTUB2/PTTG1IP/BCL2/SPIRE2/UBR5/MDM2/PPP1R10/MIF/PPP4R2/USP47 12 GO:0031330 negative regulation of cellular catabolic process 14/770 262/18722 0.192751421375481 0.500387174821631 NUPR1/HMOX1/EIF4G2/RYBP/BCL2/GOLGA2/DHX36/OPHN1/FURIN/LARP4B/FEZ2/GABARAPL2/CHMP4B/UBXN1 14 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3/770 37/18722 0.193884704127823 0.500387174821631 ETF1/RBM8A/EIF4A3 3 GO:0001990 regulation of systemic arterial blood pressure by hormone 3/770 37/18722 0.193884704127823 0.500387174821631 HSD11B2/MME/ENPEP 3 GO:0002369 T cell cytokine production 3/770 37/18722 0.193884704127823 0.500387174821631 PRKCZ/GATA3/CD55 3 GO:0002724 regulation of T cell cytokine production 3/770 37/18722 0.193884704127823 0.500387174821631 PRKCZ/GATA3/CD55 3 GO:0030513 positive regulation of BMP signaling pathway 3/770 37/18722 0.193884704127823 0.500387174821631 HES1/NUMA1/GPC3 3 GO:0048009 insulin-like growth factor receptor signaling pathway 3/770 37/18722 0.193884704127823 0.500387174821631 CRIM1/GHR/GIGYF2 3 GO:0048846 axon extension involved in axon guidance 3/770 37/18722 0.193884704127823 0.500387174821631 SEMA6A/SEMA7A/NRP1 3 GO:0060416 response to growth hormone 3/770 37/18722 0.193884704127823 0.500387174821631 GDF15/GHR/LEPROT 3 GO:0062237 protein localization to postsynapse 3/770 37/18722 0.193884704127823 0.500387174821631 PRKCZ/RAB11A/GRIP1 3 GO:0071542 dopaminergic neuron differentiation 3/770 37/18722 0.193884704127823 0.500387174821631 CTNNB1/CSNK1E/MANF 3 GO:1900077 negative regulation of cellular response to insulin stimulus 3/770 37/18722 0.193884704127823 0.500387174821631 PRKCZ/SOCS1/KANK1 3 GO:1902284 neuron projection extension involved in neuron projection guidance 3/770 37/18722 0.193884704127823 0.500387174821631 SEMA6A/SEMA7A/NRP1 3 GO:1905332 positive regulation of morphogenesis of an epithelium 3/770 37/18722 0.193884704127823 0.500387174821631 GATA3/LGR4/CTNNB1 3 GO:0098739 import across plasma membrane 10/770 177/18722 0.194048140858103 0.500387174821631 SLC2A1/SLC43A2/SLC3A2/SLC19A1/SLC7A5/SLC5A6/CLN8/IRS2/SLC12A4/SLC9A1 10 GO:0022409 positive regulation of cell-cell adhesion 15/770 284/18722 0.194101430023735 0.500387174821631 ANXA1/PRKCZ/ST3GAL4/TFRC/GATA3/CD55/PNP/HES1/GLI3/PLPP3/SOCS1/CD274/MYO10/CD46/HSPD1 15 GO:0060047 heart contraction 13/770 241/18722 0.194743209091383 0.500387174821631 CYP2J2/NEDD4L/HOPX/DSP/EPAS1/EHD3/AKAP9/JUP/MDM2/SLC9A1/PPP1R13L/ADM/SOD1 13 GO:0042471 ear morphogenesis 7/770 115/18722 0.195183510932854 0.500387174821631 GATA3/TFAP2A/GATA2/DLX5/MYO6/INSIG1/SOD1 7 GO:0033077 T cell differentiation in thymus 5/770 75/18722 0.19543434906787 0.500387174821631 GATA3/BCL2/GLI3/CTNNB1/SOD1 5 GO:0036465 synaptic vesicle recycling 5/770 75/18722 0.19543434906787 0.500387174821631 OPHN1/SYT7/SYNJ1/RAB5A/AP2M1 5 GO:1903363 negative regulation of cellular protein catabolic process 5/770 75/18722 0.19543434906787 0.500387174821631 RYBP/OPHN1/FURIN/GABARAPL2/UBXN1 5 GO:0031503 protein-containing complex localization 12/770 220/18722 0.196460602880851 0.500387174821631 PRKCZ/RAB11A/EZR/AKAP9/WASL/OPHN1/GRIP1/ZDHHC3/SUPT6H/IWS1/ALYREF/AP2M1 12 GO:0042773 ATP synthesis coupled electron transport 6/770 95/18722 0.196532501164605 0.500387174821631 NDUFA6/COX6C/COX4I1/GHITM/COX6A1/NDUFB9 6 GO:0042775 mitochondrial ATP synthesis coupled electron transport 6/770 95/18722 0.196532501164605 0.500387174821631 NDUFA6/COX6C/COX4I1/GHITM/COX6A1/NDUFB9 6 GO:0048709 oligodendrocyte differentiation 6/770 95/18722 0.196532501164605 0.500387174821631 HES1/GLI3/TNFRSF21/CTNNB1/EIF2B2/RHEB 6 GO:1901379 regulation of potassium ion transmembrane transport 6/770 95/18722 0.196532501164605 0.500387174821631 NEDD4L/KCNN4/CD63/AKAP9/KLHL24/KCNG1 6 GO:0003158 endothelium development 8/770 136/18722 0.197728578137186 0.500387174821631 EZR/BTG1/RAP1B/EDF1/RAPGEF1/CTNNB1/NRP1/RAP2C 8 GO:0045727 positive regulation of translation 8/770 136/18722 0.197728578137186 0.500387174821631 EIF4G2/SERP1/DHX36/LARP4B/DDX3X/EIF4A3/AGO2/USP16 8 GO:1900180 regulation of protein localization to nucleus 8/770 136/18722 0.197728578137186 0.500387174821631 TFRC/GLI3/JUP/UBR5/LIMK2/LATS2/LMNA/FERMT2 8 GO:1903305 regulation of regulated secretory pathway 8/770 136/18722 0.197728578137186 0.500387174821631 HMOX1/RAP1B/GATA2/SYT7/PDPK1/ARF1/RAB5A/STXBP3 8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 2/770 20/18722 0.197870943249251 0.500387174821631 ID2/BRD4 2 GO:0002834 regulation of response to tumor cell 2/770 20/18722 0.197870943249251 0.500387174821631 CD274/HSPD1 2 GO:0002837 regulation of immune response to tumor cell 2/770 20/18722 0.197870943249251 0.500387174821631 CD274/HSPD1 2 GO:0003215 cardiac right ventricle morphogenesis 2/770 20/18722 0.197870943249251 0.500387174821631 GATA3/PPP1R13L 2 GO:0006448 regulation of translational elongation 2/770 20/18722 0.197870943249251 0.500387174821631 EIF4A3/USP16 2 GO:0006525 arginine metabolic process 2/770 20/18722 0.197870943249251 0.500387174821631 ARG2/CLN3 2 GO:0006590 thyroid hormone generation 2/770 20/18722 0.197870943249251 0.500387174821631 CGA/GATA3 2 GO:0006883 cellular sodium ion homeostasis 2/770 20/18722 0.197870943249251 0.500387174821631 NEDD4L/SLC9A1 2 GO:0006896 Golgi to vacuole transport 2/770 20/18722 0.197870943249251 0.500387174821631 EHD3/CLN3 2 GO:0007194 negative regulation of adenylate cyclase activity 2/770 20/18722 0.197870943249251 0.500387174821631 GPR87/AKAP9 2 GO:0010042 response to manganese ion 2/770 20/18722 0.197870943249251 0.500387174821631 APP/HSPA5 2 GO:0032793 positive regulation of CREB transcription factor activity 2/770 20/18722 0.197870943249251 0.500387174821631 CD200/RPS6KA5 2 GO:0032930 positive regulation of superoxide anion generation 2/770 20/18722 0.197870943249251 0.500387174821631 EGFR/SOD1 2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 2/770 20/18722 0.197870943249251 0.500387174821631 BACE2/AGO2 2 GO:0043555 regulation of translation in response to stress 2/770 20/18722 0.197870943249251 0.500387174821631 EIF2AK1/DDX3X 2 GO:0043651 linoleic acid metabolic process 2/770 20/18722 0.197870943249251 0.500387174821631 CYP2J2/PNPLA8 2 GO:0045844 positive regulation of striated muscle tissue development 2/770 20/18722 0.197870943249251 0.500387174821631 BCL2/CTNNB1 2 GO:0048025 negative regulation of mRNA splicing, via spliceosome 2/770 20/18722 0.197870943249251 0.500387174821631 SAP18/RBM42 2 GO:0048636 positive regulation of muscle organ development 2/770 20/18722 0.197870943249251 0.500387174821631 BCL2/CTNNB1 2 GO:0051004 regulation of lipoprotein lipase activity 2/770 20/18722 0.197870943249251 0.500387174821631 ABHD5/FURIN 2 GO:0051900 regulation of mitochondrial depolarization 2/770 20/18722 0.197870943249251 0.500387174821631 BCL2/IFI6 2 GO:0061003 positive regulation of dendritic spine morphogenesis 2/770 20/18722 0.197870943249251 0.500387174821631 DHX36/PAFAH1B1 2 GO:0072087 renal vesicle development 2/770 20/18722 0.197870943249251 0.500387174821631 FMN1/CTNNB1 2 GO:0097150 neuronal stem cell population maintenance 2/770 20/18722 0.197870943249251 0.500387174821631 HES1/HOOK3 2 GO:1901679 nucleotide transmembrane transport 2/770 20/18722 0.197870943249251 0.500387174821631 SLC19A1/SLC25A5 2 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/770 20/18722 0.197870943249251 0.500387174821631 HSPB1/NFE2L2 2 GO:2000678 negative regulation of transcription regulatory region DNA binding 2/770 20/18722 0.197870943249251 0.500387174821631 DDIT3/MSX2 2 GO:0050804 modulation of chemical synaptic transmission 22/770 439/18722 0.197891636813361 0.500387174821631 SQSTM1/PRKCZ/KMO/EGFR/RAB11A/APP/MME/GNAI1/ERC1/AKAP9/PAIP2/RAP1B/OPHN1/SYT7/CLN3/ZDHHC3/ARF1/SYAP1/EIF4A3/RAB5A/USP8/STAU1 22 GO:0002711 positive regulation of T cell mediated immunity 4/770 56/18722 0.198025990116046 0.500387174821631 PRKCZ/GATA3/CD55/HSPD1 4 GO:0002886 regulation of myeloid leukocyte mediated immunity 4/770 56/18722 0.198025990116046 0.500387174821631 HMOX1/DHX36/GATA2/PDPK1 4 GO:0010332 response to gamma radiation 4/770 56/18722 0.198025990116046 0.500387174821631 GATA3/BCL2/HSPA5/MDM2 4 GO:0010658 striated muscle cell apoptotic process 4/770 56/18722 0.198025990116046 0.500387174821631 NUPR1/PDPK1/PPP1R10/NFE2L2 4 GO:0022029 telencephalon cell migration 4/770 56/18722 0.198025990116046 0.500387174821631 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0030166 proteoglycan biosynthetic process 4/770 56/18722 0.198025990116046 0.500387174821631 GLCE/CHPF/CANT1/CTNNB1 4 GO:0031529 ruffle organization 4/770 56/18722 0.198025990116046 0.500387174821631 EPS8L1/ARHGAP24/SH3YL1/KANK1 4 GO:0046456 icosanoid biosynthetic process 4/770 56/18722 0.198025990116046 0.500387174821631 ANXA1/PNPLA8/MGST3/MIF 4 GO:0051653 spindle localization 4/770 56/18722 0.198025990116046 0.500387174821631 SPIRE2/WASL/NUMA1/PAFAH1B1 4 GO:2000377 regulation of reactive oxygen species metabolic process 9/770 157/18722 0.198702974199451 0.50184334538057 EGFR/ARG2/TFAP2A/BCL2/ARF4/CLCN3/SOD1/NFE2L2/HSPD1 9 GO:0099177 regulation of trans-synaptic signaling 22/770 440/18722 0.200782150898297 0.506837617997069 SQSTM1/PRKCZ/KMO/EGFR/RAB11A/APP/MME/GNAI1/ERC1/AKAP9/PAIP2/RAP1B/OPHN1/SYT7/CLN3/ZDHHC3/ARF1/SYAP1/EIF4A3/RAB5A/USP8/STAU1 22 GO:0007006 mitochondrial membrane organization 7/770 116/18722 0.20094640438878 0.506995409149009 PMAIP1/BCL2/SLC25A5/CLN8/SLC9A1/HSP90AA1/GHITM 7 GO:0140029 exocytic process 5/770 76/18722 0.202691822001068 0.511140358821519 NAPA/SYNJ1/STXBP3/SNAP23/EXOC6B 5 GO:0034754 cellular hormone metabolic process 8/770 137/18722 0.203037317769916 0.511752632497467 CYP19A1/HSD17B1/CYP11A1/AKR1B1/RDH13/PNPLA2/RDH10/ADM 8 GO:0010950 positive regulation of endopeptidase activity 10/770 179/18722 0.203237145788241 0.511997319243077 PMAIP1/VCP/ADRM1/DDX3X/PRELID1/AKIRIN2/PDCD6/PSMD14/HSPE1/HSPD1 10 GO:0000578 embryonic axis specification 3/770 38/18722 0.204544077733323 0.51321406814962 TBX3/BASP1/CTNNB1 3 GO:0001825 blastocyst formation 3/770 38/18722 0.204544077733323 0.51321406814962 HOPX/FURIN/SUPT6H 3 GO:0032373 positive regulation of sterol transport 3/770 38/18722 0.204544077733323 0.51321406814962 NFKBIA/ABCG1/LRP1 3 GO:0032376 positive regulation of cholesterol transport 3/770 38/18722 0.204544077733323 0.51321406814962 NFKBIA/ABCG1/LRP1 3 GO:0035886 vascular associated smooth muscle cell differentiation 3/770 38/18722 0.204544077733323 0.51321406814962 PDCD4/HES1/ADM 3 GO:0046633 alpha-beta T cell proliferation 3/770 38/18722 0.204544077733323 0.51321406814962 CD55/ARG2/CD274 3 GO:0072524 pyridine-containing compound metabolic process 3/770 38/18722 0.204544077733323 0.51321406814962 KMO/PNP/PDXK 3 GO:1903580 positive regulation of ATP metabolic process 3/770 38/18722 0.204544077733323 0.51321406814962 NUPR1/APP/VCP 3 GO:0000302 response to reactive oxygen species 12/770 222/18722 0.204714599844093 0.513383417726781 ANXA1/HMOX1/EGFR/SDC1/BCL2/MAP1LC3A/OSER1/ERN1/MDM2/SOD1/NFE2L2/HSPD1 12 GO:0006473 protein acetylation 11/770 201/18722 0.206533376282327 0.516800099611341 NUPR1/GATA3/NCOA3/MBD3/GATA2/DIP2B/GTF2B/DDX3X/IWS1/RPS6KA5/TAOK1 11 GO:0006695 cholesterol biosynthetic process 4/770 57/18722 0.206595584673047 0.516800099611341 ABCG1/IDI1/INSIG1/SOD1 4 GO:0050891 multicellular organismal water homeostasis 4/770 57/18722 0.206595584673047 0.516800099611341 AKR1B1/GRHL1/LSR/CLDN4 4 GO:0097120 receptor localization to synapse 4/770 57/18722 0.206595584673047 0.516800099611341 PRKCZ/RAB11A/GRIP1/ZDHHC3 4 GO:1902653 secondary alcohol biosynthetic process 4/770 57/18722 0.206595584673047 0.516800099611341 ABCG1/IDI1/INSIG1/SOD1 4 GO:0032102 negative regulation of response to external stimulus 21/770 420/18722 0.207416441297183 0.518593139480112 NUCB2/SEMA6A/SERPINB2/GATA3/ARG2/SERPINE1/SEMA7A/CD200/FURIN/SERPINB9/PHLDB2/PPARD/DUSP3/C1QTNF1/DDT/LDLR/PSMB4/NRP1/MIF/SERPINF1/SOD1 21 GO:0018205 peptidyl-lysine modification 19/770 376/18722 0.208608133301451 0.520821009344886 GATA3/NCOA3/TGM2/MBD3/GATA2/DIP2B/KMT2C/TET2/GTF2B/MDM2/MLLT6/LMNA/CTNNB1/SUPT6H/IWS1/RPS6KA5/BRD4/HMG20B/UBE2I 19 GO:0032200 telomere organization 9/770 159/18722 0.208621058529479 0.520821009344886 NEK7/DHX36/PKIB/TNKS2/XRN1/PPP1R10/CTNNB1/MAP3K4/HSP90AA1 9 GO:0051170 import into nucleus 9/770 159/18722 0.208621058529479 0.520821009344886 PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/LMNA/PPP1R10/TNPO1 9 GO:0060326 cell chemotaxis 16/770 310/18722 0.208990874225063 0.521482987613165 ANXA1/PGF/HSPB1/CSF3R/VAV3/SERPINE1/MPP1/SBDS/MTUS1/AKIRIN1/BSG/DDT/PPIB/CALR/NRP1/MIF 16 GO:0120162 positive regulation of cold-induced thermogenesis 6/770 97/18722 0.209422489646023 0.52203715152883 GADD45G/ESRRG/CEBPB/EPAS1/GNAS/PRLR 6 GO:1901216 positive regulation of neuron death 6/770 97/18722 0.209422489646023 0.52203715152883 NUPR1/KMO/TFAP2A/DDIT3/UBE2M/CTNNB1 6 GO:0031016 pancreas development 5/770 77/18722 0.210038189398459 0.523048624573974 ANXA1/HES1/PDPK1/CTNNB1/RHEB 5 GO:0055117 regulation of cardiac muscle contraction 5/770 77/18722 0.210038189398459 0.523048624573974 DSP/EHD3/AKAP9/JUP/SLC9A1 5 GO:0016051 carbohydrate biosynthetic process 11/770 202/18722 0.210960582855022 0.523630186869561 ST3GAL4/ATF3/AKR1B1/AP2A1/P2RY6/ISYNA1/DDB1/IRS2/SORBS1/SLC35B4/PPP1CB 11 GO:0099504 synaptic vesicle cycle 10/770 181/18722 0.212606871341267 0.523630186869561 RAP1B/OPHN1/CLCN3/SYT7/NAPA/CTNNB1/SYNJ1/RAB5A/SNAP23/AP2M1 10 GO:0030203 glycosaminoglycan metabolic process 7/770 118/18722 0.212665535580683 0.523630186869561 ST3GAL4/AP2A1/ITIH5/GLCE/CHPF/FUCA1/IDS 7 GO:0002689 negative regulation of leukocyte chemotaxis 2/770 21/18722 0.213108974306937 0.523630186869561 DDT/MIF 2 GO:0006925 inflammatory cell apoptotic process 2/770 21/18722 0.213108974306937 0.523630186869561 ANXA1/CTSL 2 GO:0008090 retrograde axonal transport 2/770 21/18722 0.213108974306937 0.523630186869561 PAFAH1B1/SOD1 2 GO:0010766 negative regulation of sodium ion transport 2/770 21/18722 0.213108974306937 0.523630186869561 NEDD4L/COMMD1 2 GO:0010878 cholesterol storage 2/770 21/18722 0.213108974306937 0.523630186869561 ABCG1/PPARD 2 GO:0016075 rRNA catabolic process 2/770 21/18722 0.213108974306937 0.523630186869561 DEDD2/XRN1 2 GO:0019985 translesion synthesis 2/770 21/18722 0.213108974306937 0.523630186869561 VCP/USP43 2 GO:0021533 cell differentiation in hindbrain 2/770 21/18722 0.213108974306937 0.523630186869561 GATA2/OPHN1 2 GO:0032288 myelin assembly 2/770 21/18722 0.213108974306937 0.523630186869561 EPB41L3/ITGB4 2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 2/770 21/18722 0.213108974306937 0.523630186869561 WASL/ARF1 2 GO:0044342 type B pancreatic cell proliferation 2/770 21/18722 0.213108974306937 0.523630186869561 NUPR1/ERRFI1 2 GO:0045717 negative regulation of fatty acid biosynthetic process 2/770 21/18722 0.213108974306937 0.523630186869561 ACADVL/INSIG1 2 GO:0046514 ceramide catabolic process 2/770 21/18722 0.213108974306937 0.523630186869561 NEU1/GLA 2 GO:0060117 auditory receptor cell development 2/770 21/18722 0.213108974306937 0.523630186869561 PAFAH1B1/SOD1 2 GO:0060445 branching involved in salivary gland morphogenesis 2/770 21/18722 0.213108974306937 0.523630186869561 TGM2/NRP1 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/770 21/18722 0.213108974306937 0.523630186869561 SEMA7A/DHX36 2 GO:0071498 cellular response to fluid shear stress 2/770 21/18722 0.213108974306937 0.523630186869561 MTSS1/NFE2L2 2 GO:0072111 cell proliferation involved in kidney development 2/770 21/18722 0.213108974306937 0.523630186869561 GATA3/GPC3 2 GO:0072170 metanephric tubule development 2/770 21/18722 0.213108974306937 0.523630186869561 HES1/LGR4 2 GO:0072243 metanephric nephron epithelium development 2/770 21/18722 0.213108974306937 0.523630186869561 HES1/LGR4 2 GO:1901863 positive regulation of muscle tissue development 2/770 21/18722 0.213108974306937 0.523630186869561 BCL2/CTNNB1 2 GO:1902644 tertiary alcohol metabolic process 2/770 21/18722 0.213108974306937 0.523630186869561 CYP11A1/AKR1B1 2 GO:1903429 regulation of cell maturation 2/770 21/18722 0.213108974306937 0.523630186869561 BCL2/MAP3K13 2 GO:2000291 regulation of myoblast proliferation 2/770 21/18722 0.213108974306937 0.523630186869561 PPARD/MALAT1 2 GO:0002931 response to ischemia 4/770 58/18722 0.215270038602086 0.525726639652971 SQSTM1/BCL2/CPEB4/HSPD1 4 GO:0007405 neuroblast proliferation 4/770 58/18722 0.215270038602086 0.525726639652971 GLI3/TEAD3/CTNNB1/PAFAH1B1 4 GO:0018208 peptidyl-proline modification 4/770 58/18722 0.215270038602086 0.525726639652971 P4HB/FKBP2/EGLN2/PPIB 4 GO:0035904 aorta development 4/770 58/18722 0.215270038602086 0.525726639652971 HES1/HECTD1/LRP1/ADAMTS6 4 GO:0042743 hydrogen peroxide metabolic process 4/770 58/18722 0.215270038602086 0.525726639652971 EGFR/GPX3/PRDX6/SOD1 4 GO:0097035 regulation of membrane lipid distribution 4/770 58/18722 0.215270038602086 0.525726639652971 ATP10D/KCNN4/ABCG1/PRELID1 4 GO:0016572 histone phosphorylation 3/770 39/18722 0.215333749053123 0.525726639652971 UBE2B/CDK2/RPS6KA5 3 GO:0032728 positive regulation of interferon-beta production 3/770 39/18722 0.215333749053123 0.525726639652971 DDX3X/TBK1/HSP90AA1 3 GO:0045923 positive regulation of fatty acid metabolic process 3/770 39/18722 0.215333749053123 0.525726639652971 ANXA1/PPARD/IRS2 3 GO:0086091 regulation of heart rate by cardiac conduction 3/770 39/18722 0.215333749053123 0.525726639652971 DSP/AKAP9/JUP 3 GO:0090207 regulation of triglyceride metabolic process 3/770 39/18722 0.215333749053123 0.525726639652971 ABHD5/LDLR/PNPLA2 3 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 3/770 39/18722 0.215333749053123 0.525726639652971 EHD3/P2RY6/SLC9A1 3 GO:1903115 regulation of actin filament-based movement 3/770 39/18722 0.215333749053123 0.525726639652971 DSP/AKAP9/JUP 3 GO:0070301 cellular response to hydrogen peroxide 6/770 98/18722 0.21597682685143 0.527038456513553 ANXA1/MAP1LC3A/OSER1/ERN1/MDM2/NFE2L2 6 GO:0034284 response to monosaccharide 12/770 225/18722 0.217374506159417 0.529642635472277 PIM3/ERN1/KRT18/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/EIF2B2/SERPINF1 12 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 5/770 78/18722 0.217469161584644 0.529642635472277 PMAIP1/VCP/PDCD6/HSPE1/HSPD1 5 GO:0009064 glutamine family amino acid metabolic process 5/770 78/18722 0.217469161584644 0.529642635472277 ARG2/RIMKLB/CLN3/MTHFS/ASNSD1 5 GO:0034637 cellular carbohydrate biosynthetic process 5/770 78/18722 0.217469161584644 0.529642635472277 AKR1B1/ISYNA1/IRS2/SORBS1/PPP1CB 5 GO:0050768 negative regulation of neurogenesis 8/770 140/18722 0.21929623654717 0.533831532347116 SEMA6A/HES1/SEMA7A/HOOK3/DIP2B/CTNNB1/LDLR/NRP1 8 GO:0002703 regulation of leukocyte mediated immunity 12/770 226/18722 0.221666174530534 0.539337181487134 PRKCZ/TFRC/HMOX1/GATA3/CD55/DHX36/GATA2/SERPINB9/PDPK1/CD46/SUPT6H/HSPD1 12 GO:0033209 tumor necrosis factor-mediated signaling pathway 6/770 99/18722 0.222600217945751 0.541081407816428 NFKBIA/KRT18/KRT8/HSPA1B/COMMD7/ACTN4 6 GO:0060291 long-term synaptic potentiation 6/770 99/18722 0.222600217945751 0.541081407816428 SQSTM1/PRKCZ/APP/MME/PAIP2/STAU1 6 GO:0021537 telencephalon development 13/770 248/18722 0.222753822610744 0.541190784041607 TACC2/SLC2A1/GNG12/HES1/GLI3/SEMA7A/ID2/ADGRG1/CTNNB1/DLX5/LRP1/TACC1/PAFAH1B1 13 GO:0051100 negative regulation of binding 9/770 162/18722 0.223861897098606 0.542600324815976 DAB2/HMOX1/DDIT3/NFKBIA/LRPAP1/GOLGA2/MSX2/EIF4A3/CSNK1E 9 GO:0021885 forebrain cell migration 4/770 59/18722 0.224042212385816 0.542600324815976 GLI3/ADGRG1/CTNNB1/PAFAH1B1 4 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4/770 59/18722 0.224042212385816 0.542600324815976 PGF/HSPB1/NRP1/PDCD6 4 GO:0051055 negative regulation of lipid biosynthetic process 4/770 59/18722 0.224042212385816 0.542600324815976 ACADVL/ORMDL1/INSIG1/SOD1 4 GO:0051568 histone H3-K4 methylation 4/770 59/18722 0.224042212385816 0.542600324815976 GATA3/KMT2C/TET2/CTNNB1 4 GO:0071901 negative regulation of protein serine/threonine kinase activity 7/770 120/18722 0.224628802813241 0.542600324815976 CDKN1C/PDCD4/HEXIM1/PKIB/CEBPA/LATS2/DNAJA1 7 GO:0001895 retina homeostasis 5/770 79/18722 0.224980419053107 0.542600324815976 HSPB1/SLC2A1/CLCN3/CLN8/SOD1 5 GO:0006029 proteoglycan metabolic process 5/770 79/18722 0.224980419053107 0.542600324815976 PPARD/GLCE/CHPF/CANT1/CTNNB1 5 GO:0050808 synapse organization 21/770 426/18722 0.225942100988114 0.542600324815976 APP/PPFIBP1/ERC1/VCP/DHX36/WASL/ARF4/OPHN1/RER1/CLN3/PPFIA1/DLG5/CHMP2B/ARF1/CTNNB1/NRP1/PAFAH1B1/CDKL5/STAU1/HSPA8/CAST 21 GO:0098657 import into cell 12/770 227/18722 0.225992537657726 0.542600324815976 SLC2A1/SLC43A2/SLC3A2/SLC38A1/SLC19A1/SLC7A5/SLC5A6/CLN8/IRS2/SLC12A4/TSG101/SLC9A1 12 GO:0014037 Schwann cell differentiation 3/770 40/18722 0.226239750177511 0.542600324815976 ERBB3/ITGB4/SOD1 3 GO:0030866 cortical actin cytoskeleton organization 3/770 40/18722 0.226239750177511 0.542600324815976 EZR/EPB41L3/CALR 3 GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/770 40/18722 0.226239750177511 0.542600324815976 ATXN7/CAMSAP2/TAOK1 3 GO:0032094 response to food 3/770 40/18722 0.226239750177511 0.542600324815976 NUCB2/HSD11B2/GHR 3 GO:0035329 hippo signaling 3/770 40/18722 0.226239750177511 0.542600324815976 TEAD3/LATS2/DLG5 3 GO:0043001 Golgi to plasma membrane protein transport 3/770 40/18722 0.226239750177511 0.542600324815976 GOLGA4/KRT18/CLN3 3 GO:0060412 ventricular septum morphogenesis 3/770 40/18722 0.226239750177511 0.542600324815976 TBX3/HES1/TGFBR3 3 GO:0071276 cellular response to cadmium ion 3/770 40/18722 0.226239750177511 0.542600324815976 HMOX1/EGFR/SOD1 3 GO:0071526 semaphorin-plexin signaling pathway 3/770 40/18722 0.226239750177511 0.542600324815976 SEMA6A/SEMA7A/NRP1 3 GO:0150077 regulation of neuroinflammatory response 3/770 40/18722 0.226239750177511 0.542600324815976 NUPR1/CD200/LDLR 3 GO:0002053 positive regulation of mesenchymal cell proliferation 2/770 22/18722 0.228451832523363 0.542600324815976 IRS2/CTNNB1 2 GO:0002089 lens morphogenesis in camera-type eye 2/770 22/18722 0.228451832523363 0.542600324815976 TBC1D20/CTNNB1 2 GO:0006359 regulation of transcription by RNA polymerase III 2/770 22/18722 0.228451832523363 0.542600324815976 DHX36/CEBPA 2 GO:0006379 mRNA cleavage 2/770 22/18722 0.228451832523363 0.542600324815976 ERN1/AGO2 2 GO:0007413 axonal fasciculation 2/770 22/18722 0.228451832523363 0.542600324815976 TNFRSF21/NRP1 2 GO:0008211 glucocorticoid metabolic process 2/770 22/18722 0.228451832523363 0.542600324815976 CYP11A1/HSD11B2 2 GO:0031061 negative regulation of histone methylation 2/770 22/18722 0.228451832523363 0.542600324815976 MLLT6/SUPT6H 2 GO:0032402 melanosome transport 2/770 22/18722 0.228451832523363 0.542600324815976 RAB11A/RAB1A 2 GO:0032693 negative regulation of interleukin-10 production 2/770 22/18722 0.228451832523363 0.542600324815976 CD274/TNFRSF21 2 GO:0032700 negative regulation of interleukin-17 production 2/770 22/18722 0.228451832523363 0.542600324815976 ARG2/DDIT3 2 GO:0032891 negative regulation of organic acid transport 2/770 22/18722 0.228451832523363 0.542600324815976 SLC43A2/IRS2 2 GO:0033617 mitochondrial cytochrome c oxidase assembly 2/770 22/18722 0.228451832523363 0.542600324815976 COX17/COX20 2 GO:0036120 cellular response to platelet-derived growth factor stimulus 2/770 22/18722 0.228451832523363 0.542600324815976 SYAP1/ERRFI1 2 GO:0045061 thymic T cell selection 2/770 22/18722 0.228451832523363 0.542600324815976 GATA3/GLI3 2 GO:0045540 regulation of cholesterol biosynthetic process 2/770 22/18722 0.228451832523363 0.542600324815976 ABCG1/SOD1 2 GO:0045624 positive regulation of T-helper cell differentiation 2/770 22/18722 0.228451832523363 0.542600324815976 ANXA1/PRKCZ 2 GO:0045663 positive regulation of myoblast differentiation 2/770 22/18722 0.228451832523363 0.542600324815976 BTG1/AKIRIN1 2 GO:0046628 positive regulation of insulin receptor signaling pathway 2/770 22/18722 0.228451832523363 0.542600324815976 PRKCZ/SORBS1 2 GO:0048026 positive regulation of mRNA splicing, via spliceosome 2/770 22/18722 0.228451832523363 0.542600324815976 PRDX6/HSPA8 2 GO:0050860 negative regulation of T cell receptor signaling pathway 2/770 22/18722 0.228451832523363 0.542600324815976 EZR/DUSP3 2 GO:0051151 negative regulation of smooth muscle cell differentiation 2/770 22/18722 0.228451832523363 0.542600324815976 PDCD4/FOXO4 2 GO:0060444 branching involved in mammary gland duct morphogenesis 2/770 22/18722 0.228451832523363 0.542600324815976 TBX3/KDM5B 2 GO:0061042 vascular wound healing 2/770 22/18722 0.228451832523363 0.542600324815976 SERPINE1/GATA2 2 GO:0106030 neuron projection fasciculation 2/770 22/18722 0.228451832523363 0.542600324815976 TNFRSF21/NRP1 2 GO:0106118 regulation of sterol biosynthetic process 2/770 22/18722 0.228451832523363 0.542600324815976 ABCG1/SOD1 2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 2/770 22/18722 0.228451832523363 0.542600324815976 DLX5/NFE2L2 2 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 2/770 22/18722 0.228451832523363 0.542600324815976 HMOX1/GATA2 2 GO:0006664 glycolipid metabolic process 6/770 100/18722 0.22928974223212 0.544331007881208 ST3GAL4/B3GNT5/NEU1/GLTP/FUCA1/GLA 6 GO:0042177 negative regulation of protein catabolic process 7/770 121/18722 0.230696752708998 0.546889590270664 EGFR/RYBP/OPHN1/FURIN/GABARAPL2/AZIN1/UBXN1 7 GO:0043244 regulation of protein-containing complex disassembly 7/770 121/18722 0.230696752708998 0.546889590270664 SCIN/ETF1/ATXN7/CLN3/UVRAG/CAMSAP2/TAOK1 7 GO:0048706 embryonic skeletal system development 7/770 121/18722 0.230696752708998 0.546889590270664 TFAP2A/GLI3/KIAA1217/CTNNB1/EIF4A3/RDH10/PBX1 7 GO:0071560 cellular response to transforming growth factor beta stimulus 13/770 250/18722 0.231053116854783 0.547473933089579 GDF15/DAB2/CDKN1C/PEG10/ZNF703/BCL9L/HSPA5/FURIN/LATS2/PDPK1/SNX6/TGFBR3/FERMT2 13 GO:0051604 protein maturation 15/770 294/18722 0.231167828332786 0.54748540331857 CPM/BACE2/CTSL/SERPINE1/GLI3/MME/FURIN/CLN3/MDM2/SEC11C/CALR/ENPEP/TMEM59/HSPD1/CAST 15 GO:0002040 sprouting angiogenesis 10/770 185/18722 0.231857380180914 0.548857636789309 ANXA1/PGF/HMOX1/SEMA6A/PIK3C2A/EPHB4/HDAC5/GATA2/PDPK1/NRP1 10 GO:0120193 tight junction organization 5/770 80/18722 0.232567620412454 0.550277517813513 SVEP1/CLDN7/LSR/MPP7/CLDN4 5 GO:0002712 regulation of B cell mediated immunity 4/770 60/18722 0.232904992885655 0.550291882194983 TFRC/CD55/CD46/SUPT6H 4 GO:0002889 regulation of immunoglobulin mediated immune response 4/770 60/18722 0.232904992885655 0.550291882194983 TFRC/CD55/CD46/SUPT6H 4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 4/770 60/18722 0.232904992885655 0.550291882194983 NABP1/FOXO4/USP47/TAOK1 4 GO:0002697 regulation of immune effector process 17/770 339/18722 0.233694206347409 0.551894895843194 ANXA1/PRKCZ/TFRC/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36/GATA2/DNAJB9/SERPINB9/PDPK1/CD46/SUPT6H/CD59/HSPD1 17 GO:0050806 positive regulation of synaptic transmission 9/770 164/18722 0.234250519804738 0.552946632016585 SQSTM1/PRKCZ/KMO/EGFR/APP/MME/PAIP2/ZDHHC3/STAU1 9 GO:0033157 regulation of intracellular protein transport 12/770 229/18722 0.234746486511639 0.553592873775436 TCAF1/GLI3/JUP/LEPROT/UBR5/EDEM1/SAR1A/MDM2/ERLEC1/SAR1B/INSIG1/STOM 12 GO:0071356 cellular response to tumor necrosis factor 12/770 229/18722 0.234746486511639 0.553592873775436 GATA3/NFKBIA/KRT18/KRT8/CEBPA/TNFRSF21/ZFAND6/TANK/HSPA1B/COMMD7/ACTN4/NFE2L2 12 GO:0003015 heart process 13/770 251/18722 0.235249141025639 0.554515832417577 CYP2J2/NEDD4L/HOPX/DSP/EPAS1/EHD3/AKAP9/JUP/MDM2/SLC9A1/PPP1R13L/ADM/SOD1 13 GO:0048024 regulation of mRNA splicing, via spliceosome 6/770 101/18722 0.236042452648548 0.55585989676168 MBNL3/SAP18/RBM8A/RBM42/PRDX6/HSPA8 6 GO:1903509 liposaccharide metabolic process 6/770 101/18722 0.236042452648548 0.55585989676168 ST3GAL4/B3GNT5/NEU1/GLTP/FUCA1/GLA 6 GO:0071478 cellular response to radiation 10/770 186/18722 0.236770569095381 0.557120143243743 GATA3/MME/DHX36/HSPA5/OPN3/MDM2/DDB1/TANK/SWI5/USP47 10 GO:0009167 purine ribonucleoside monophosphate metabolic process 3/770 41/18722 0.23724843346643 0.557120143243743 AK3/PNP/MPP1 3 GO:0031062 positive regulation of histone methylation 3/770 41/18722 0.23724843346643 0.557120143243743 LMNA/CTNNB1/BRD4 3 GO:0042307 positive regulation of protein import into nucleus 3/770 41/18722 0.23724843346643 0.557120143243743 GLI3/JUP/UBR5 3 GO:0050856 regulation of T cell receptor signaling pathway 3/770 41/18722 0.23724843346643 0.557120143243743 EZR/KCNN4/DUSP3 3 GO:0071634 regulation of transforming growth factor beta production 3/770 41/18722 0.23724843346643 0.557120143243743 CD200/FURIN/CD46 3 GO:0002573 myeloid leukocyte differentiation 11/770 208/18722 0.238328512424962 0.559129462059126 TFRC/CEBPB/GATA3/APP/EIF2AK1/GATA2/ID2/CEBPA/CTNNB1/GPC3/PAFAH1B1 11 GO:0006836 neurotransmitter transport 11/770 208/18722 0.238328512424962 0.559129462059126 KMO/SLC38A1/SLC6A8/RAP1B/SYT7/NAPA/CLN8/SYNJ1/RAB5A/STXBP3/SNAP23 11 GO:0050796 regulation of insulin secretion 9/770 165/18722 0.239509423822068 0.561635510073112 PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 9 GO:0001942 hair follicle development 5/770 81/18722 0.240226410055594 0.562583406825021 EGFR/BCL2/LGR4/NUMA1/CTNNB1 5 GO:0010324 membrane invagination 8/770 144/18722 0.241692407459068 0.562583406825021 RHOBTB1/GULP1/SPIRE2/GATA2/CLCN3/SNX9/ARF1/CHMP2A 8 GO:0045860 positive regulation of protein kinase activity 19/770 386/18722 0.241832014970501 0.562583406825021 PRKCZ/EGFR/GHR/ERN1/SOCS1/DVL3/ERBB3/SNX9/PDPK1/SYAP1/DDX3X/RICTOR/PRLR/MAP3K13/MAP3K4/HSP90AA1/TAOK1/FERMT2/CCND3 19 GO:0034113 heterotypic cell-cell adhesion 4/770 61/18722 0.241851307649974 0.562583406825021 GLDN/DSP/CD200/JUP 4 GO:0043954 cellular component maintenance 4/770 61/18722 0.241851307649974 0.562583406825021 MTSS1/ERC1/OPHN1/FERMT2 4 GO:0050994 regulation of lipid catabolic process 4/770 61/18722 0.241851307649974 0.562583406825021 ABHD5/IRS2/LDLR/PNPLA2 4 GO:0032677 regulation of interleukin-8 production 6/770 102/18722 0.242855380112008 0.562583406825021 ANXA1/SERPINE1/DDIT3/RAB1A/ANXA4/HSPA1B 6 GO:0034308 primary alcohol metabolic process 6/770 102/18722 0.242855380112008 0.562583406825021 CYP11A1/AKR1B1/RDH13/ACSS1/PNPLA2/RDH10 6 GO:1902106 negative regulation of leukocyte differentiation 6/770 102/18722 0.242855380112008 0.562583406825021 ANXA1/GLI3/SOCS1/GATA2/ID2/CTNNB1 6 GO:0002366 leukocyte activation involved in immune response 14/770 275/18722 0.243435163538125 0.562583406825021 ANXA1/PRKCZ/TFRC/HMOX1/GATA3/DYSF/GATA2/PDPK1/CD46/SUPT6H/PI4K2A/STXBP3/SNAP23/HSPD1 14 GO:0043270 positive regulation of ion transport 14/770 275/18722 0.243435163538125 0.562583406825021 TCAF1/KMO/CEBPB/KCNN4/EHD3/AKAP9/P2RY6/PRSS8/PDPK1/MLLT6/ARF1/SLC9A1/COX17/ACTN4 14 GO:0002052 positive regulation of neuroblast proliferation 2/770 23/18722 0.243865173337758 0.562583406825021 GLI3/CTNNB1 2 GO:0002082 regulation of oxidative phosphorylation 2/770 23/18722 0.243865173337758 0.562583406825021 NUPR1/VCP 2 GO:0002363 alpha-beta T cell lineage commitment 2/770 23/18722 0.243865173337758 0.562583406825021 CTSL/BCL2 2 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 2/770 23/18722 0.243865173337758 0.562583406825021 MME/ENPEP 2 GO:0003323 type B pancreatic cell development 2/770 23/18722 0.243865173337758 0.562583406825021 PDPK1/RHEB 2 GO:0006929 substrate-dependent cell migration 2/770 23/18722 0.243865173337758 0.562583406825021 OPHN1/NRP1 2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 2/770 23/18722 0.243865173337758 0.562583406825021 CLDN7/CLDN4 2 GO:0016578 histone deubiquitination 2/770 23/18722 0.243865173337758 0.562583406825021 ATXN7/USP16 2 GO:0019430 removal of superoxide radicals 2/770 23/18722 0.243865173337758 0.562583406825021 SOD1/NFE2L2 2 GO:0021871 forebrain regionalization 2/770 23/18722 0.243865173337758 0.562583406825021 GLI3/ADGRG1 2 GO:0030325 adrenal gland development 2/770 23/18722 0.243865173337758 0.562583406825021 ARID5B/PBX1 2 GO:0031280 negative regulation of cyclase activity 2/770 23/18722 0.243865173337758 0.562583406825021 GPR87/AKAP9 2 GO:0032401 establishment of melanosome localization 2/770 23/18722 0.243865173337758 0.562583406825021 RAB11A/RAB1A 2 GO:0034695 response to prostaglandin E 2/770 23/18722 0.243865173337758 0.562583406825021 P2RY6/TGFBR3 2 GO:0036119 response to platelet-derived growth factor 2/770 23/18722 0.243865173337758 0.562583406825021 SYAP1/ERRFI1 2 GO:0036303 lymph vessel morphogenesis 2/770 23/18722 0.243865173337758 0.562583406825021 SVEP1/LGALS8 2 GO:0042438 melanin biosynthetic process 2/770 23/18722 0.243865173337758 0.562583406825021 OPN3/DDT 2 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 2/770 23/18722 0.243865173337758 0.562583406825021 CTSL/BCL2 2 GO:0051446 positive regulation of meiotic cell cycle 2/770 23/18722 0.243865173337758 0.562583406825021 UBE2B/OVOL1 2 GO:0051882 mitochondrial depolarization 2/770 23/18722 0.243865173337758 0.562583406825021 BCL2/IFI6 2 GO:0051904 pigment granule transport 2/770 23/18722 0.243865173337758 0.562583406825021 RAB11A/RAB1A 2 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 2/770 23/18722 0.243865173337758 0.562583406825021 GDF15/GCM1 2 GO:0099590 neurotransmitter receptor internalization 2/770 23/18722 0.243865173337758 0.562583406825021 OPHN1/AP2M1 2 GO:2000737 negative regulation of stem cell differentiation 2/770 23/18722 0.243865173337758 0.562583406825021 HES1/NFE2L2 2 GO:1902904 negative regulation of supramolecular fiber organization 9/770 166/18722 0.244809647104591 0.564500912319379 SCIN/ATXN7/PHLDB2/PPFIA1/LDLR/KANK1/CAMSAP2/HSPA8/TAOK1 9 GO:0009895 negative regulation of catabolic process 16/770 320/18722 0.245772407370837 0.566458790901424 NUPR1/HMOX1/EGFR/EIF4G2/RYBP/BCL2/GOLGA2/DHX36/OPHN1/FURIN/LARP4B/FEZ2/GABARAPL2/CHMP4B/AZIN1/UBXN1 16 GO:0007269 neurotransmitter secretion 8/770 145/18722 0.24740876771587 0.569440133731261 KMO/RAP1B/SYT7/NAPA/SYNJ1/RAB5A/STXBP3/SNAP23 8 GO:0051961 negative regulation of nervous system development 8/770 145/18722 0.24740876771587 0.569440133731261 SEMA6A/HES1/SEMA7A/HOOK3/DIP2B/CTNNB1/LDLR/NRP1 8 GO:0099643 signal release from synapse 8/770 145/18722 0.24740876771587 0.569440133731261 KMO/RAP1B/SYT7/NAPA/SYNJ1/RAB5A/STXBP3/SNAP23 8 GO:0021575 hindbrain morphogenesis 3/770 42/18722 0.248346493678363 0.57001869092551 HES1/OPHN1/HSPA5 3 GO:0021879 forebrain neuron differentiation 3/770 42/18722 0.248346493678363 0.57001869092551 HES1/GATA2/NRP1 3 GO:0032689 negative regulation of interferon-gamma production 3/770 42/18722 0.248346493678363 0.57001869092551 GATA3/DDIT3/CD274 3 GO:0032965 regulation of collagen biosynthetic process 3/770 42/18722 0.248346493678363 0.57001869092551 PPARD/SUCO/ERRFI1 3 GO:0033003 regulation of mast cell activation 3/770 42/18722 0.248346493678363 0.57001869092551 HMOX1/GATA2/PDPK1 3 GO:0048489 synaptic vesicle transport 3/770 42/18722 0.248346493678363 0.57001869092551 ARF1/CTNNB1/SYNJ1 3 GO:0002027 regulation of heart rate 6/770 103/18722 0.24972553776553 0.572656398842906 DSP/EPAS1/AKAP9/JUP/MDM2/ADM 6 GO:0032637 interleukin-8 production 6/770 103/18722 0.24972553776553 0.572656398842906 ANXA1/SERPINE1/DDIT3/RAB1A/ANXA4/HSPA1B 6 GO:0007588 excretion 4/770 62/18722 0.250874138286204 0.572917429459283 HMOX1/NEDD4L/CLN3/MLLT6 4 GO:0009311 oligosaccharide metabolic process 4/770 62/18722 0.250874138286204 0.572917429459283 ST3GAL4/BRAF/NEU1/GLA 4 GO:0019933 cAMP-mediated signaling 4/770 62/18722 0.250874138286204 0.572917429459283 UBE2B/GNAI1/CAP2/ADM 4 GO:0032623 interleukin-2 production 4/770 62/18722 0.250874138286204 0.572917429459283 ANXA1/GATA3/EZR/PNP 4 GO:0032663 regulation of interleukin-2 production 4/770 62/18722 0.250874138286204 0.572917429459283 ANXA1/GATA3/EZR/PNP 4 GO:0032757 positive regulation of interleukin-8 production 4/770 62/18722 0.250874138286204 0.572917429459283 SERPINE1/DDIT3/RAB1A/HSPA1B 4 GO:0045576 mast cell activation 4/770 62/18722 0.250874138286204 0.572917429459283 HMOX1/GATA2/PDPK1/SNAP23 4 GO:0046824 positive regulation of nucleocytoplasmic transport 4/770 62/18722 0.250874138286204 0.572917429459283 GLI3/JUP/UBR5/MDM2 4 GO:1902750 negative regulation of cell cycle G2/M phase transition 4/770 62/18722 0.250874138286204 0.572917429459283 NABP1/FOXO4/USP47/TAOK1 4 GO:0046034 ATP metabolic process 14/770 277/18722 0.251666019835214 0.574356077595428 NUPR1/APP/NDUFA6/BPGM/VCP/COX6C/HSPA1B/CLPX/COX4I1/GHITM/COX7B/COX6A1/HSPA8/NDUFB9 14 GO:0009060 aerobic respiration 10/770 189/18722 0.251734632443993 0.574356077595428 NUPR1/NDUFA6/VCP/COX6C/ACO2/COX4I1/GHITM/COX7B/COX6A1/NDUFB9 10 GO:0043491 protein kinase B signaling 11/770 211/18722 0.252491335375704 0.57581891266688 GDF15/EGFR/GATA3/DDIT3/C1QTNF1/RICTOR/PHLPP1/HSP90AA1/PDCD6/MYDGF/FERMT2 11 GO:0051053 negative regulation of DNA metabolic process 7/770 125/18722 0.25549383149354 0.580167374103071 GATA3/OTUB2/UBR5/ZNF91/TNKS2/XRN1/SUB1 7 GO:0071621 granulocyte chemotaxis 7/770 125/18722 0.25549383149354 0.580167374103071 ANXA1/CSF3R/VAV3/MPP1/AKIRIN1/BSG/PPIB 7 GO:2000027 regulation of animal organ morphogenesis 7/770 125/18722 0.25549383149354 0.580167374103071 DAB2/GATA3/LGR4/DVL3/SP6/CTNNB1/GPC3 7 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 9/770 168/18722 0.255528729302541 0.580167374103071 ANXA1/PRKCZ/TFRC/GATA3/CD55/CD274/CD46/SUPT6H/HSPD1 9 GO:1902806 regulation of cell cycle G1/S phase transition 9/770 168/18722 0.255528729302541 0.580167374103071 ANXA1/EGFR/BCL2/ID2/MDM2/CDK2/DDX3X/GIGYF2/CCND3 9 GO:2000241 regulation of reproductive process 9/770 168/18722 0.255528729302541 0.580167374103071 NUPR1/UBE2B/PHLDA2/OVOL1/GCM1/CTNNB1/CALR/AGO2/SERPINF1 9 GO:0043367 CD4-positive, alpha-beta T cell differentiation 5/770 83/18722 0.255741304717889 0.580167374103071 ANXA1/PRKCZ/GATA3/CTSL/SOCS1 5 GO:0050672 negative regulation of lymphocyte proliferation 5/770 83/18722 0.255741304717889 0.580167374103071 CEBPB/ARG2/CD274/TNFRSF21/DLG5 5 GO:0071559 response to transforming growth factor beta 13/770 256/18722 0.256667455826191 0.580167374103071 GDF15/DAB2/CDKN1C/PEG10/ZNF703/BCL9L/HSPA5/FURIN/LATS2/PDPK1/SNX6/TGFBR3/FERMT2 13 GO:0009749 response to glucose 11/770 212/18722 0.257277282226739 0.580167374103071 PIM3/ERN1/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/EIF2B2/SERPINF1 11 GO:0006817 phosphate ion transport 2/770 24/18722 0.259317293104218 0.580167374103071 CEBPB/SLC20A1 2 GO:0010155 regulation of proton transport 2/770 24/18722 0.259317293104218 0.580167374103071 COX17/ACTN4 2 GO:0010288 response to lead ion 2/770 24/18722 0.259317293104218 0.580167374103071 APP/MAP1LC3A 2 GO:0018230 peptidyl-L-cysteine S-palmitoylation 2/770 24/18722 0.259317293104218 0.580167374103071 ZDHHC3/ZDHHC20 2 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 2/770 24/18722 0.259317293104218 0.580167374103071 ZDHHC3/ZDHHC20 2 GO:0030859 polarized epithelial cell differentiation 2/770 24/18722 0.259317293104218 0.580167374103071 OPHN1/DLG5 2 GO:0032528 microvillus organization 2/770 24/18722 0.259317293104218 0.580167374103071 GLDN/EZR 2 GO:0032928 regulation of superoxide anion generation 2/770 24/18722 0.259317293104218 0.580167374103071 EGFR/SOD1 2 GO:0033032 regulation of myeloid cell apoptotic process 2/770 24/18722 0.259317293104218 0.580167374103071 ANXA1/BCL2 2 GO:0036010 protein localization to endosome 2/770 24/18722 0.259317293104218 0.580167374103071 EZR/NRP1 2 GO:0045649 regulation of macrophage differentiation 2/770 24/18722 0.259317293104218 0.580167374103071 GATA2/ID2 2 GO:0048641 regulation of skeletal muscle tissue development 2/770 24/18722 0.259317293104218 0.580167374103071 BCL2/CTNNB1 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/770 24/18722 0.259317293104218 0.580167374103071 FURIN/SNX9 2 GO:0051123 RNA polymerase II preinitiation complex assembly 2/770 24/18722 0.259317293104218 0.580167374103071 GTF2B/PSMC6 2 GO:0051905 establishment of pigment granule localization 2/770 24/18722 0.259317293104218 0.580167374103071 RAB11A/RAB1A 2 GO:0060571 morphogenesis of an epithelial fold 2/770 24/18722 0.259317293104218 0.580167374103071 CTNNB1/RDH10 2 GO:0071676 negative regulation of mononuclear cell migration 2/770 24/18722 0.259317293104218 0.580167374103071 CD200/WASL 2 GO:0072530 purine-containing compound transmembrane transport 2/770 24/18722 0.259317293104218 0.580167374103071 SLC19A1/SLC25A5 2 GO:0090343 positive regulation of cell aging 2/770 24/18722 0.259317293104218 0.580167374103071 ARG2/LMNA 2 GO:0120255 olefinic compound biosynthetic process 2/770 24/18722 0.259317293104218 0.580167374103071 HSD17B1/ADM 2 GO:0007059 chromosome segregation 17/770 346/18722 0.259437936296479 0.580167374103071 UBE2B/TOP1/RAB11A/TLK1/ARL8B/SLC25A5/CHMP2B/UVRAG/NUMA1/DDX3X/CTNNB1/VPS4B/BEX4/CHMP4B/EML4/CHMP2A/UBE2I 17 GO:0006509 membrane protein ectodomain proteolysis 3/770 43/18722 0.259520986730031 0.580167374103071 BACE2/FURIN/SNX9 3 GO:0014014 negative regulation of gliogenesis 3/770 43/18722 0.259520986730031 0.580167374103071 HES1/CTNNB1/LDLR 3 GO:0016266 O-glycan processing 3/770 43/18722 0.259520986730031 0.580167374103071 ST3GAL4/B3GNT5/C1GALT1 3 GO:0042181 ketone biosynthetic process 3/770 43/18722 0.259520986730031 0.580167374103071 HSD17B1/COQ10B/ADM 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/770 43/18722 0.259520986730031 0.580167374103071 NUPR1/BCL2/MIF 3 GO:0045494 photoreceptor cell maintenance 3/770 43/18722 0.259520986730031 0.580167374103071 SLC2A1/CLCN3/CLN8 3 GO:0071604 transforming growth factor beta production 3/770 43/18722 0.259520986730031 0.580167374103071 CD200/FURIN/CD46 3 GO:0098815 modulation of excitatory postsynaptic potential 3/770 43/18722 0.259520986730031 0.580167374103071 PRKCZ/APP/EIF4A3 3 GO:0140353 lipid export from cell 3/770 43/18722 0.259520986730031 0.580167374103071 CYP19A1/KDM5B/C1QTNF1 3 GO:1903793 positive regulation of anion transport 3/770 43/18722 0.259520986730031 0.580167374103071 TCAF1/KMO/CEBPB 3 GO:1904591 positive regulation of protein import 3/770 43/18722 0.259520986730031 0.580167374103071 GLI3/JUP/UBR5 3 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 3/770 43/18722 0.259520986730031 0.580167374103071 HMOX1/PDCD4/GNA12 3 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 3/770 43/18722 0.259520986730031 0.580167374103071 BCL2/IFI6/HSPA1B 3 GO:0002704 negative regulation of leukocyte mediated immunity 4/770 63/18722 0.259966532919056 0.580382273089451 HMOX1/CD55/SERPINB9/CD46 4 GO:0046902 regulation of mitochondrial membrane permeability 4/770 63/18722 0.259966532919056 0.580382273089451 PMAIP1/BCL2/SLC25A5/SLC9A1 4 GO:1904589 regulation of protein import 4/770 63/18722 0.259966532919056 0.580382273089451 GLI3/JUP/UBR5/HSPA8 4 GO:0021543 pallium development 9/770 169/18722 0.260944891916106 0.581983487751995 TACC2/SLC2A1/GNG12/GLI3/ADGRG1/CTNNB1/LRP1/TACC1/PAFAH1B1 9 GO:0031214 biomineral tissue development 9/770 169/18722 0.260944891916106 0.581983487751995 CEBPB/TFAP2A/LGR4/PHOSPHO1/SBDS/SLC4A2/TUFT1/GPC3/SLC20A1 9 GO:0030217 T cell differentiation 13/770 257/18722 0.261034135084429 0.581983487751995 ANXA1/PRKCZ/GATA3/CTSL/PNP/BCL2/GLI3/SOCS1/CD46/CTNNB1/PRELID1/KDELR1/SOD1 13 GO:0006936 muscle contraction 17/770 347/18722 0.2632015597385 0.585142996214786 TBX3/PIK3C2A/ARG2/NEDD4L/DSP/SLC6A8/ANXA6/EHD3/AKAP9/JUP/TPM4/PPP1R12B/SLC9A1/PPP1R13L/UTRN/SOD1/MYOF 17 GO:0006112 energy reserve metabolic process 5/770 84/18722 0.263588692483267 0.585142996214786 PHLDA2/STK40/IRS2/SORBS1/PPP1CB 5 GO:0022404 molting cycle process 5/770 84/18722 0.263588692483267 0.585142996214786 EGFR/BCL2/LGR4/NUMA1/CTNNB1 5 GO:0022405 hair cycle process 5/770 84/18722 0.263588692483267 0.585142996214786 EGFR/BCL2/LGR4/NUMA1/CTNNB1 5 GO:0032945 negative regulation of mononuclear cell proliferation 5/770 84/18722 0.263588692483267 0.585142996214786 CEBPB/ARG2/CD274/TNFRSF21/DLG5 5 GO:0042440 pigment metabolic process 5/770 84/18722 0.263588692483267 0.585142996214786 HMOX1/ALAS1/BCL2/OPN3/DDT 5 GO:0098586 cellular response to virus 5/770 84/18722 0.263588692483267 0.585142996214786 IFI6/ARF1/DDX3X/LGALS8/HSP90AA1 5 GO:0016079 synaptic vesicle exocytosis 6/770 105/18722 0.263625532109612 0.585142996214786 RAP1B/SYT7/NAPA/SYNJ1/RAB5A/SNAP23 6 GO:0032231 regulation of actin filament bundle assembly 6/770 105/18722 0.263625532109612 0.585142996214786 MTSS1/PHLDB2/PPFIA1/SLC9A1/NRP1/FERMT2 6 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 6/770 105/18722 0.263625532109612 0.585142996214786 EPS8L1/WASL/CDC42EP4/AKIRIN1/MIEN1/NRP1 6 GO:0002181 cytoplasmic translation 8/770 148/18722 0.264812589834745 0.58725462178306 ETF1/CPEB4/EIF5/DHX36/EIF2S2/EIF4H/EIF4A1/EIF3J 8 GO:0010212 response to ionizing radiation 8/770 148/18722 0.264812589834745 0.58725462178306 ANXA1/GATA3/NABP1/BCL2/HSPA5/MDM2/TANK/SWI5 8 GO:0042593 glucose homeostasis 13/770 258/18722 0.265426905780308 0.588093495555035 BACE2/PIM3/ERN1/CEBPA/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SERPINF1 13 GO:0045165 cell fate commitment 13/770 258/18722 0.265426905780308 0.588093495555035 TBX3/GATA3/CTSL/HES1/BCL2/EPAS1/GLI3/GCM1/TEAD3/GATA2/ID2/CTNNB1/NRP1 13 GO:0000082 G1/S transition of mitotic cell cycle 11/770 214/18722 0.266941135871966 0.591185635577782 ANXA1/EGFR/BCL2/ID2/LATS2/MDM2/CDK2/DDX3X/GIGYF2/BRD4/CCND3 11 GO:0001654 eye development 18/770 371/18722 0.268575532030262 0.593251130684891 GATA3/TFAP2A/RDH13/BCL2/GLI3/SMOC1/LIMK2/TENM3/TBC1D20/CLN8/KDM5B/CTNNB1/PPP1R13L/RDH10/NRP1/SERPINF1/PBX1/EFEMP1 18 GO:0001885 endothelial cell development 4/770 64/18722 0.269121617758752 0.593251130684891 EZR/RAP1B/RAPGEF1/RAP2C 4 GO:0048857 neural nucleus development 4/770 64/18722 0.269121617758752 0.593251130684891 BASP1/BCL2/HSPA5/DYNLL1 4 GO:0050771 negative regulation of axonogenesis 4/770 64/18722 0.269121617758752 0.593251130684891 SEMA6A/SEMA7A/DIP2B/NRP1 4 GO:1900076 regulation of cellular response to insulin stimulus 4/770 64/18722 0.269121617758752 0.593251130684891 PRKCZ/SOCS1/KANK1/SORBS1 4 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/770 64/18722 0.269121617758752 0.593251130684891 RYBP/OPHN1/GABARAPL2/UBXN1 4 GO:1903409 reactive oxygen species biosynthetic process 4/770 64/18722 0.269121617758752 0.593251130684891 ARG2/CLCN3/SOD1/HSPD1 4 GO:0033500 carbohydrate homeostasis 13/770 259/18722 0.269845074821994 0.593251130684891 BACE2/PIM3/ERN1/CEBPA/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP/CCDC186/STXBP3/SERPINF1 13 GO:0046822 regulation of nucleocytoplasmic transport 6/770 106/18722 0.270649342986888 0.593251130684891 GLI3/JUP/UBR5/MDM2/SUPT6H/IWS1 6 GO:1903707 negative regulation of hemopoiesis 6/770 106/18722 0.270649342986888 0.593251130684891 ANXA1/GLI3/SOCS1/GATA2/ID2/CTNNB1 6 GO:0051592 response to calcium ion 8/770 149/18722 0.270693078892417 0.593251130684891 EGFR/SDC1/BRAF/JUND/HSPA5/SYT7/PDCD6/SEC31A 8 GO:0002066 columnar/cuboidal epithelial cell development 3/770 44/18722 0.270759345367139 0.593251130684891 YIPF6/PDPK1/RHEB 3 GO:0005978 glycogen biosynthetic process 3/770 44/18722 0.270759345367139 0.593251130684891 IRS2/SORBS1/PPP1CB 3 GO:0007528 neuromuscular junction development 3/770 44/18722 0.270759345367139 0.593251130684891 APP/PPFIBP1/RER1 3 GO:0009126 purine nucleoside monophosphate metabolic process 3/770 44/18722 0.270759345367139 0.593251130684891 AK3/PNP/MPP1 3 GO:0009250 glucan biosynthetic process 3/770 44/18722 0.270759345367139 0.593251130684891 IRS2/SORBS1/PPP1CB 3 GO:0021762 substantia nigra development 3/770 44/18722 0.270759345367139 0.593251130684891 BASP1/HSPA5/DYNLL1 3 GO:0032620 interleukin-17 production 3/770 44/18722 0.270759345367139 0.593251130684891 ARG2/DDIT3/SLC7A5 3 GO:0032660 regulation of interleukin-17 production 3/770 44/18722 0.270759345367139 0.593251130684891 ARG2/DDIT3/SLC7A5 3 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 3/770 44/18722 0.270759345367139 0.593251130684891 ARF4/OPHN1/DLG5 3 GO:0048066 developmental pigmentation 3/770 44/18722 0.270759345367139 0.593251130684891 CD63/BCL2/GLI3 3 GO:0048806 genitalia development 3/770 44/18722 0.270759345367139 0.593251130684891 TBX3/LGR4/CTNNB1 3 GO:0060324 face development 3/770 44/18722 0.270759345367139 0.593251130684891 ARID5B/DLX5/ZFAND5 3 GO:0150076 neuroinflammatory response 3/770 44/18722 0.270759345367139 0.593251130684891 NUPR1/CD200/LDLR 3 GO:0072384 organelle transport along microtubule 5/770 85/18722 0.271490247350052 0.593251130684891 PRKCZ/CLN3/RAB1A/ARMCX3/PAFAH1B1 5 GO:0098773 skin epidermis development 5/770 85/18722 0.271490247350052 0.593251130684891 EGFR/BCL2/LGR4/NUMA1/CTNNB1 5 GO:0110148 biomineralization 9/770 171/18722 0.271883626290364 0.593251130684891 CEBPB/TFAP2A/LGR4/PHOSPHO1/SBDS/SLC4A2/TUFT1/GPC3/SLC20A1 9 GO:0007517 muscle organ development 16/770 327/18722 0.272940140444769 0.593251130684891 ARID5B/NUPR1/MAFF/BASP1/ATF3/DSP/BCL2/SERP1/FOXO4/CD164/AKIRIN1/CTNNB1/UTRN/CHD2/TGFBR3/HMG20B 16 GO:0006658 phosphatidylserine metabolic process 2/770 25/18722 0.274778970423586 0.593251130684891 SERINC5/PTDSS1 2 GO:0010447 response to acidic pH 2/770 25/18722 0.274778970423586 0.593251130684891 SLC9A1/SERPINF1 2 GO:0010560 positive regulation of glycoprotein biosynthetic process 2/770 25/18722 0.274778970423586 0.593251130684891 GOLGA2/CTNNB1 2 GO:0010842 retina layer formation 2/770 25/18722 0.274778970423586 0.593251130684891 TFAP2A/RDH13 2 GO:0015012 heparan sulfate proteoglycan biosynthetic process 2/770 25/18722 0.274778970423586 0.593251130684891 GLCE/CTNNB1 2 GO:0021846 cell proliferation in forebrain 2/770 25/18722 0.274778970423586 0.593251130684891 GLI3/HOOK3 2 GO:0030318 melanocyte differentiation 2/770 25/18722 0.274778970423586 0.593251130684891 BCL2/GLI3 2 GO:0032331 negative regulation of chondrocyte differentiation 2/770 25/18722 0.274778970423586 0.593251130684891 CTNNB1/EFEMP1 2 GO:0032400 melanosome localization 2/770 25/18722 0.274778970423586 0.593251130684891 RAB11A/RAB1A 2 GO:0033119 negative regulation of RNA splicing 2/770 25/18722 0.274778970423586 0.593251130684891 SAP18/RBM42 2 GO:0033622 integrin activation 2/770 25/18722 0.274778970423586 0.593251130684891 RAP1B/FERMT2 2 GO:0034389 lipid droplet organization 2/770 25/18722 0.274778970423586 0.593251130684891 TBC1D20/PNPLA2 2 GO:0035902 response to immobilization stress 2/770 25/18722 0.274778970423586 0.593251130684891 FOXO4/MDM2 2 GO:0036315 cellular response to sterol 2/770 25/18722 0.274778970423586 0.593251130684891 GRAMD1C/INSIG1 2 GO:0042730 fibrinolysis 2/770 25/18722 0.274778970423586 0.593251130684891 SERPINB2/SERPINE1 2 GO:0044550 secondary metabolite biosynthetic process 2/770 25/18722 0.274778970423586 0.593251130684891 OPN3/DDT 2 GO:0051450 myoblast proliferation 2/770 25/18722 0.274778970423586 0.593251130684891 PPARD/MALAT1 2 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 2/770 25/18722 0.274778970423586 0.593251130684891 NFKBIA/HSPA1B 2 GO:0071450 cellular response to oxygen radical 2/770 25/18722 0.274778970423586 0.593251130684891 SOD1/NFE2L2 2 GO:0071451 cellular response to superoxide 2/770 25/18722 0.274778970423586 0.593251130684891 SOD1/NFE2L2 2 GO:0072202 cell differentiation involved in metanephros development 2/770 25/18722 0.274778970423586 0.593251130684891 LGR4/CTNNB1 2 GO:0072207 metanephric epithelium development 2/770 25/18722 0.274778970423586 0.593251130684891 HES1/LGR4 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/770 25/18722 0.274778970423586 0.593251130684891 PRKCZ/SORBS1 2 GO:1901798 positive regulation of signal transduction by p53 class mediator 2/770 25/18722 0.274778970423586 0.593251130684891 PMAIP1/HEXIM1 2 GO:1902932 positive regulation of alcohol biosynthetic process 2/770 25/18722 0.274778970423586 0.593251130684891 P2RY6/ABCG1 2 GO:1903792 negative regulation of anion transport 2/770 25/18722 0.274778970423586 0.593251130684891 SLC43A2/GABRE 2 GO:1903959 regulation of anion transmembrane transport 2/770 25/18722 0.274778970423586 0.593251130684891 TCAF1/SLC43A2 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/770 25/18722 0.274778970423586 0.593251130684891 GNA12/NFE2L2 2 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 2/770 25/18722 0.274778970423586 0.593251130684891 MDM2/LRP1 2 GO:1905048 regulation of metallopeptidase activity 2/770 25/18722 0.274778970423586 0.593251130684891 LRP1/CLDN4 2 GO:0007219 Notch signaling pathway 9/770 172/18722 0.277403432217356 0.597815252021912 APP/HES1/AAK1/NFKBIA/GATA2/MIB1/CEBPA/CD46/ANXA4 9 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/770 107/18722 0.277718340170616 0.597815252021912 PRKCZ/TFRC/GATA3/CD55/CD274/HSPD1 6 GO:0005976 polysaccharide metabolic process 6/770 107/18722 0.277718340170616 0.597815252021912 PHLDA2/STK40/AP2A1/IRS2/SORBS1/PPP1CB 6 GO:0042303 molting cycle 6/770 107/18722 0.277718340170616 0.597815252021912 EGFR/BCL2/LGR4/NUMA1/CTNNB1/PPP1R13L 6 GO:0042633 hair cycle 6/770 107/18722 0.277718340170616 0.597815252021912 EGFR/BCL2/LGR4/NUMA1/CTNNB1/PPP1R13L 6 GO:0006487 protein N-linked glycosylation 4/770 65/18722 0.278332607804703 0.597815252021912 TUSC3/MAN1C1/RPN2/DDOST 4 GO:0035418 protein localization to synapse 4/770 65/18722 0.278332607804703 0.597815252021912 PRKCZ/HSPB1/RAB11A/GRIP1 4 GO:0038034 signal transduction in absence of ligand 4/770 65/18722 0.278332607804703 0.597815252021912 BCL2/IFI6/ERBB3/HSPA1B 4 GO:0046513 ceramide biosynthetic process 4/770 65/18722 0.278332607804703 0.597815252021912 SPTSSA/SAMD8/CLN8/ORMDL1 4 GO:0048645 animal organ formation 4/770 65/18722 0.278332607804703 0.597815252021912 HES1/GLI3/CTNNB1/RDH10 4 GO:0060389 pathway-restricted SMAD protein phosphorylation 4/770 65/18722 0.278332607804703 0.597815252021912 GDF15/DAB2/LRP1/TGFBR3 4 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 4/770 65/18722 0.278332607804703 0.597815252021912 BCL2/IFI6/ERBB3/HSPA1B 4 GO:0009798 axis specification 5/770 86/18722 0.279441647643794 0.598906550627537 TBX3/BASP1/DDIT3/CTNNB1/GPC3 5 GO:0022406 membrane docking 5/770 86/18722 0.279441647643794 0.598906550627537 EZR/CLN3/STX5/RAB7A/STXBP3 5 GO:0034103 regulation of tissue remodeling 5/770 86/18722 0.279441647643794 0.598906550627537 TFRC/EGFR/SYT7/TMBIM1/SUCO 5 GO:0035023 regulation of Rho protein signal transduction 5/770 86/18722 0.279441647643794 0.598906550627537 EPS8L1/OPHN1/ADGRG1/KANK1/NRP1 5 GO:1903510 mucopolysaccharide metabolic process 5/770 86/18722 0.279441647643794 0.598906550627537 ST3GAL4/AP2A1/ITIH5/GLCE/CHPF 5 GO:0006022 aminoglycan metabolic process 7/770 129/18722 0.28102579073679 0.601784063275215 ST3GAL4/AP2A1/ITIH5/GLCE/CHPF/FUCA1/IDS 7 GO:0007093 mitotic cell cycle checkpoint signaling 7/770 129/18722 0.28102579073679 0.601784063275215 NABP1/FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 7 GO:0015850 organic hydroxy compound transport 14/770 284/18722 0.281253745936562 0.602013494846173 CYP19A1/ARL8B/GRAMD1C/NFKBIA/FURIN/SYT7/ABCG1/KDM5B/C1QTNF1/VPS4B/LDLR/LRP1/SLC16A3/OSBP 14 GO:0002920 regulation of humoral immune response 3/770 45/18722 0.282049392007401 0.602681012166758 CD55/CD46/CD59 3 GO:0003254 regulation of membrane depolarization 3/770 45/18722 0.282049392007401 0.602681012166758 NEDD4L/BCL2/IFI6 3 GO:0046189 phenol-containing compound biosynthetic process 3/770 45/18722 0.282049392007401 0.602681012166758 GATA3/OPN3/DDT 3 GO:1904646 cellular response to amyloid-beta 3/770 45/18722 0.282049392007401 0.602681012166758 APP/LRP1/SNX6 3 GO:0048592 eye morphogenesis 8/770 151/18722 0.282562505264071 0.603026225396847 TFAP2A/RDH13/BCL2/GLI3/TENM3/TBC1D20/CTNNB1/EFEMP1 8 GO:1904064 positive regulation of cation transmembrane transport 8/770 151/18722 0.282562505264071 0.603026225396847 KCNN4/EHD3/AKAP9/P2RY6/PDPK1/ARF1/SLC9A1/ACTN4 8 GO:1901605 alpha-amino acid metabolic process 10/770 195/18722 0.28257399885644 0.603026225396847 KMO/ARG2/SERINC5/RIMKLB/CLN3/MTHFS/SMS/CDO1/ASNSD1/AZIN1 10 GO:0150063 visual system development 18/770 375/18722 0.283453719339862 0.604644641896632 GATA3/TFAP2A/RDH13/BCL2/GLI3/SMOC1/LIMK2/TENM3/TBC1D20/CLN8/KDM5B/CTNNB1/PPP1R13L/RDH10/NRP1/SERPINF1/PBX1/EFEMP1 18 GO:0007029 endoplasmic reticulum organization 5/770 87/18722 0.28743859743665 0.611860612618379 TMEM33/LMAN2/TOR1AIP2/SEC31A/REEP5 5 GO:0019646 aerobic electron transport chain 5/770 87/18722 0.28743859743665 0.611860612618379 NDUFA6/COX6C/COX4I1/COX6A1/NDUFB9 5 GO:0044070 regulation of anion transport 5/770 87/18722 0.28743859743665 0.611860612618379 TCAF1/KMO/CEBPB/SLC43A2/GABRE 5 GO:0050918 positive chemotaxis 4/770 66/18722 0.287592816711234 0.611860612618379 PGF/LRP1/NRP1/MIF 4 GO:1902476 chloride transmembrane transport 4/770 66/18722 0.287592816711234 0.611860612618379 SLC26A2/GABRE/CLCN3/SLC12A4 4 GO:2000272 negative regulation of signaling receptor activity 4/770 66/18722 0.287592816711234 0.611860612618379 LRPAP1/TSG101/SNX6/ERRFI1 4 GO:0031032 actomyosin structure organization 10/770 196/18722 0.287818839248943 0.611860612618379 EPB41L3/FHDC1/KRT8/PHLDB2/PPFIA1/NEBL/SLC9A1/NRP1/SORBS1/FERMT2 10 GO:0090276 regulation of peptide hormone secretion 10/770 196/18722 0.287818839248943 0.611860612618379 EGFR/PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 10 GO:0034765 regulation of ion transmembrane transport 23/770 491/18722 0.289462032546266 0.612270441909736 TCAF1/FXYD3/CLIC3/SLC43A2/NEDD4L/APP/KCNN4/CD63/EHD3/AKAP9/P2RY6/KLHL24/TMEM37/PDPK1/ARF1/SLC9A1/KCNG1/UBQLN1/UTRN/STOM/COX17/COMMD1/ACTN4 23 GO:0002026 regulation of the force of heart contraction 2/770 26/18722 0.29022331603267 0.612270441909736 SLC9A1/ADM 2 GO:0002092 positive regulation of receptor internalization 2/770 26/18722 0.29022331603267 0.612270441909736 CD63/AP2M1 2 GO:0002418 immune response to tumor cell 2/770 26/18722 0.29022331603267 0.612270441909736 CD274/HSPD1 2 GO:0006027 glycosaminoglycan catabolic process 2/770 26/18722 0.29022331603267 0.612270441909736 FUCA1/IDS 2 GO:0006706 steroid catabolic process 2/770 26/18722 0.29022331603267 0.612270441909736 CYP19A1/STS 2 GO:0008535 respiratory chain complex IV assembly 2/770 26/18722 0.29022331603267 0.612270441909736 COX17/COX20 2 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 2/770 26/18722 0.29022331603267 0.612270441909736 NFKBIA/HSPA1B 2 GO:0043094 cellular metabolic compound salvage 2/770 26/18722 0.29022331603267 0.612270441909736 PNP/PDXK 2 GO:0046697 decidualization 2/770 26/18722 0.29022331603267 0.612270441909736 PPARD/BSG 2 GO:0048668 collateral sprouting 2/770 26/18722 0.29022331603267 0.612270441909736 APP/LRP1 2 GO:0051350 negative regulation of lyase activity 2/770 26/18722 0.29022331603267 0.612270441909736 GPR87/AKAP9 2 GO:0051560 mitochondrial calcium ion homeostasis 2/770 26/18722 0.29022331603267 0.612270441909736 TGM2/ANXA6 2 GO:0051875 pigment granule localization 2/770 26/18722 0.29022331603267 0.612270441909736 RAB11A/RAB1A 2 GO:0060037 pharyngeal system development 2/770 26/18722 0.29022331603267 0.612270441909736 GATA3/HES1 2 GO:0097066 response to thyroid hormone 2/770 26/18722 0.29022331603267 0.612270441909736 CTSL/AKR1B1 2 GO:0097186 amelogenesis 2/770 26/18722 0.29022331603267 0.612270441909736 CSF3R/SLC4A2 2 GO:0099637 neurotransmitter receptor transport 2/770 26/18722 0.29022331603267 0.612270441909736 RAB11A/GRIP1 2 GO:0002456 T cell mediated immunity 6/770 109/18722 0.291979835950333 0.615454958773482 PRKCZ/GATA3/CD55/CD46/GNL1/HSPD1 6 GO:0043266 regulation of potassium ion transport 6/770 109/18722 0.291979835950333 0.615454958773482 NEDD4L/KCNN4/CD63/AKAP9/KLHL24/KCNG1 6 GO:0034198 cellular response to amino acid starvation 3/770 46/18722 0.293379348999298 0.617360344621411 ATF3/MAP1LC3A/RRAGC 3 GO:0043300 regulation of leukocyte degranulation 3/770 46/18722 0.293379348999298 0.617360344621411 HMOX1/GATA2/PDPK1 3 GO:0044818 mitotic G2/M transition checkpoint 3/770 46/18722 0.293379348999298 0.617360344621411 NABP1/FOXO4/TAOK1 3 GO:0046839 phospholipid dephosphorylation 3/770 46/18722 0.293379348999298 0.617360344621411 MTMR10/PLPP3/SYNJ1 3 GO:0006661 phosphatidylinositol biosynthetic process 7/770 131/18722 0.294022738724842 0.618192112686029 PIK3C2A/SOCS1/TTC7B/SH3YL1/PI4K2A/SYNJ1/TMEM150A 7 GO:1904950 negative regulation of establishment of protein localization 7/770 131/18722 0.294022738724842 0.618192112686029 ANXA1/PIM3/CD200/ERLEC1/INSIG1/RAB11FIP1/DNAJA1 7 GO:0009880 embryonic pattern specification 4/770 67/18722 0.296895665842964 0.62370619852255 TBX3/BASP1/CTNNB1/NRP1 4 GO:0070527 platelet aggregation 4/770 67/18722 0.296895665842964 0.62370619852255 HSPB1/GNAS/C1QTNF1/STXBP3 4 GO:0002698 negative regulation of immune effector process 6/770 110/18722 0.299166322821157 0.62821145664468 ANXA1/HMOX1/CD55/SERPINB9/CD46/CD59 6 GO:0060537 muscle tissue development 19/770 403/18722 0.302791730066212 0.635556525240073 TBX3/NUPR1/MAFF/HOPX/ATF3/DSP/BCL2/MSX2/ID2/NEBL/LMNA/AKIRIN1/CTNNB1/CALR/SLC9A1/PPP1R13L/TGFBR3/ZFAND5/HMG20B 19 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 3/770 47/18722 0.30473784652325 0.635879965912228 HSD11B2/MME/ENPEP 3 GO:0010712 regulation of collagen metabolic process 3/770 47/18722 0.30473784652325 0.635879965912228 PPARD/SUCO/ERRFI1 3 GO:0042311 vasodilation 3/770 47/18722 0.30473784652325 0.635879965912228 EGFR/PPARD/SOD1 3 GO:0045581 negative regulation of T cell differentiation 3/770 47/18722 0.30473784652325 0.635879965912228 ANXA1/GLI3/SOCS1 3 GO:0043405 regulation of MAP kinase activity 9/770 177/18722 0.305450794426364 0.635879965912228 PDCD4/EGFR/GHR/ERN1/DVL3/TSG101/MAP3K13/MAP3K4/DNAJA1 9 GO:0001958 endochondral ossification 2/770 27/18722 0.305625630816734 0.635879965912228 PHOSPHO1/DLX5 2 GO:0009651 response to salt stress 2/770 27/18722 0.305625630816734 0.635879965912228 KMO/AKR1B1 2 GO:0010894 negative regulation of steroid biosynthetic process 2/770 27/18722 0.305625630816734 0.635879965912228 INSIG1/SOD1 2 GO:0018126 protein hydroxylation 2/770 27/18722 0.305625630816734 0.635879965912228 P4HB/EGLN2 2 GO:0031954 positive regulation of protein autophosphorylation 2/770 27/18722 0.305625630816734 0.635879965912228 DDX3X/RAP2C 2 GO:0032703 negative regulation of interleukin-2 production 2/770 27/18722 0.305625630816734 0.635879965912228 GATA3/EZR 2 GO:0034505 tooth mineralization 2/770 27/18722 0.305625630816734 0.635879965912228 TFAP2A/SLC4A2 2 GO:0036075 replacement ossification 2/770 27/18722 0.305625630816734 0.635879965912228 PHOSPHO1/DLX5 2 GO:0042403 thyroid hormone metabolic process 2/770 27/18722 0.305625630816734 0.635879965912228 CGA/GATA3 2 GO:0045606 positive regulation of epidermal cell differentiation 2/770 27/18722 0.305625630816734 0.635879965912228 NCOA3/NUMA1 2 GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/770 27/18722 0.305625630816734 0.635879965912228 GDF15/GCM1 2 GO:0061437 renal system vasculature development 2/770 27/18722 0.305625630816734 0.635879965912228 HES1/NRP1 2 GO:0061440 kidney vasculature development 2/770 27/18722 0.305625630816734 0.635879965912228 HES1/NRP1 2 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 2/770 27/18722 0.305625630816734 0.635879965912228 SEMA6A/CD63 2 GO:1903859 regulation of dendrite extension 2/770 27/18722 0.305625630816734 0.635879965912228 NEDD4L/SPAG9 2 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 2/770 27/18722 0.305625630816734 0.635879965912228 TNKS2/XRN1 2 GO:0007585 respiratory gaseous exchange by respiratory system 4/770 68/18722 0.306234692548164 0.636166890142691 MAN1A2/BPGM/STK40/ZFAND5 4 GO:0051148 negative regulation of muscle cell differentiation 4/770 68/18722 0.306234692548164 0.636166890142691 PDCD4/HDAC5/ID2/FOXO4 4 GO:1901016 regulation of potassium ion transmembrane transporter activity 4/770 68/18722 0.306234692548164 0.636166890142691 NEDD4L/AKAP9/KLHL24/KCNG1 4 GO:0048880 sensory system development 18/770 381/18722 0.306274206191515 0.636166890142691 GATA3/TFAP2A/RDH13/BCL2/GLI3/SMOC1/LIMK2/TENM3/TBC1D20/CLN8/KDM5B/CTNNB1/PPP1R13L/RDH10/NRP1/SERPINF1/PBX1/EFEMP1 18 GO:0034614 cellular response to reactive oxygen species 8/770 155/18722 0.306686213238568 0.636492045217736 ANXA1/EGFR/MAP1LC3A/OSER1/ERN1/MDM2/SOD1/NFE2L2 8 GO:0051147 regulation of muscle cell differentiation 8/770 155/18722 0.306686213238568 0.636492045217736 PDCD4/HOPX/BCL2/HDAC5/ID2/FOXO4/MDM2/SUPT6H 8 GO:0002791 regulation of peptide secretion 10/770 200/18722 0.309055580721853 0.641142364170272 EGFR/PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 10 GO:0035265 organ growth 9/770 178/18722 0.311140030466485 0.64519799076758 CGA/BASP1/BCL2/DUSP9/ANXA6/SERP1/LATS2/TGFBR3/SOD1 9 GO:0032392 DNA geometric change 5/770 90/18722 0.311660287041007 0.645739380592656 ANXA1/HMGB3/DHX36/DDX3X/CHD2 5 GO:0070664 negative regulation of leukocyte proliferation 5/770 90/18722 0.311660287041007 0.645739380592656 CEBPB/ARG2/CD274/TNFRSF21/DLG5 5 GO:0001764 neuron migration 8/770 156/18722 0.312787076311129 0.647804655552101 SEMA6A/GATA3/GATA2/ADGRG1/CTNNB1/NRP1/PAFAH1B1/CDKL5 8 GO:0000956 nuclear-transcribed mRNA catabolic process 6/770 112/18722 0.313635831724089 0.648502658652 ETF1/DHX36/RBM8A/XRN1/EIF4A3/AGO2 6 GO:0002821 positive regulation of adaptive immune response 6/770 112/18722 0.313635831724089 0.648502658652 PRKCZ/TFRC/GATA3/CD55/CD274/HSPD1 6 GO:0043406 positive regulation of MAP kinase activity 6/770 112/18722 0.313635831724089 0.648502658652 EGFR/GHR/ERN1/DVL3/MAP3K13/MAP3K4 6 GO:0003012 muscle system process 21/770 452/18722 0.313691292875742 0.648502658652 TBX3/HMOX1/PIK3C2A/ARG2/NEDD4L/DSP/SLC6A8/ANXA6/FBXO32/EHD3/AKAP9/JUP/TPM4/PPP1R12B/LMNA/SLC9A1/PPP1R13L/UTRN/ERRFI1/SOD1/MYOF 21 GO:0003007 heart morphogenesis 12/770 246/18722 0.313774816377678 0.648502658652 TBX3/PDCD4/GATA3/EPHB4/DSP/HES1/MIB1/MDM2/CTNNB1/PPP1R13L/NRP1/TGFBR3 12 GO:0009952 anterior/posterior pattern specification 10/770 201/18722 0.314423235404551 0.649573375630545 TBX3/BASP1/HES1/DDIT3/GLI3/MIB1/BHLHE40/CTNNB1/GPC3/PBX1 10 GO:0050805 negative regulation of synaptic transmission 4/770 69/18722 0.31560355767899 0.651471635424362 GNAI1/RAP1B/ARF1/EIF4A3 4 GO:0051966 regulation of synaptic transmission, glutamatergic 4/770 69/18722 0.31560355767899 0.651471635424362 KMO/EGFR/OPHN1/CLN3 4 GO:0014706 striated muscle tissue development 18/770 384/18722 0.317886567412414 0.655912532263379 TBX3/NUPR1/MAFF/HOPX/ATF3/DSP/BCL2/MSX2/ID2/NEBL/LMNA/AKIRIN1/CTNNB1/CALR/SLC9A1/PPP1R13L/TGFBR3/HMG20B 18 GO:1902107 positive regulation of leukocyte differentiation 8/770 157/18722 0.318912397229876 0.656821347862611 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/ID2/CD46 8 GO:1903708 positive regulation of hemopoiesis 8/770 157/18722 0.318912397229876 0.656821347862611 ANXA1/PRKCZ/GATA3/PNP/GLI3/SOCS1/ID2/CD46 8 GO:0051492 regulation of stress fiber assembly 5/770 91/18722 0.319797181626055 0.656821347862611 PHLDB2/PPFIA1/SLC9A1/NRP1/FERMT2 5 GO:0055006 cardiac cell development 5/770 91/18722 0.319797181626055 0.656821347862611 TBX3/PDCD4/NEBL/LMNA/TGFBR3 5 GO:0090087 regulation of peptide transport 10/770 202/18722 0.319811915224838 0.656821347862611 EGFR/PIM3/SERP1/SYT7/ABCG1/PPARD/IRS2/DYNLL1/LRP1/OSBP 10 GO:0000303 response to superoxide 2/770 28/18722 0.320963271532301 0.656821347862611 SOD1/NFE2L2 2 GO:0001945 lymph vessel development 2/770 28/18722 0.320963271532301 0.656821347862611 SVEP1/LGALS8 2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 2/770 28/18722 0.320963271532301 0.656821347862611 SAR1B/CALR 2 GO:0002507 tolerance induction 2/770 28/18722 0.320963271532301 0.656821347862611 CD274/PHLPP1 2 GO:0006516 glycoprotein catabolic process 2/770 28/18722 0.320963271532301 0.656821347862611 CTSL/EDEM1 2 GO:0008299 isoprenoid biosynthetic process 2/770 28/18722 0.320963271532301 0.656821347862611 IDI1/RDH10 2 GO:0031440 regulation of mRNA 3'-end processing 2/770 28/18722 0.320963271532301 0.656821347862611 PAPOLA/DHX36 2 GO:0042983 amyloid precursor protein biosynthetic process 2/770 28/18722 0.320963271532301 0.656821347862611 BACE2/AGO2 2 GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/770 28/18722 0.320963271532301 0.656821347862611 BACE2/AGO2 2 GO:0045589 regulation of regulatory T cell differentiation 2/770 28/18722 0.320963271532301 0.656821347862611 SOCS1/CD46 2 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 2/770 28/18722 0.320963271532301 0.656821347862611 SOCS1/LEPROT 2 GO:0051503 adenine nucleotide transport 2/770 28/18722 0.320963271532301 0.656821347862611 SLC19A1/SLC25A5 2 GO:0060325 face morphogenesis 2/770 28/18722 0.320963271532301 0.656821347862611 ARID5B/DLX5 2 GO:0070076 histone lysine demethylation 2/770 28/18722 0.320963271532301 0.656821347862611 UBE2B/KDM5B 2 GO:0080111 DNA demethylation 2/770 28/18722 0.320963271532301 0.656821347862611 GATA3/TET2 2 GO:0016053 organic acid biosynthetic process 15/770 316/18722 0.321390469317121 0.657425578245983 ANXA1/KMO/SERINC5/ABHD3/ACSS1/CLN3/PNPLA8/MGST3/ACADVL/CDO1/OSBP/RDH10/ASNSD1/MIF/INSIG1 15 GO:0006790 sulfur compound metabolic process 16/770 339/18722 0.321717626387704 0.657824756787003 SLC26A2/GSTA3/ST3GAL4/FAR2/CLIC3/SLC19A2/GSTA4/SLC19A3/GHR/ACSS1/SMS/GLCE/CHPF/CDO1/SOD1/NFE2L2 16 GO:0071897 DNA biosynthetic process 9/770 180/18722 0.322586885791094 0.658777245771646 NEK7/VCP/PKIB/USP43/TNKS2/XRN1/CTNNB1/MAP3K4/HSP90AA1 9 GO:0002696 positive regulation of leukocyte activation 19/770 409/18722 0.32538600706649 0.658777245771646 ANXA1/PRKCZ/TFRC/GATA3/CD55/VAV3/PNP/HES1/BCL2/GLI3/SOCS1/CD274/JUND/GATA2/CEBPA/CD46/IRS2/MIF/HSPD1 19 GO:0099024 plasma membrane invagination 7/770 136/18722 0.327044744341542 0.658777245771646 RHOBTB1/GULP1/SPIRE2/GATA2/CLCN3/SNX9/ARF1 7 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3/770 49/18722 0.32749705562592 0.658777245771646 TFRC/SUPT6H/HSPD1 3 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3/770 49/18722 0.32749705562592 0.658777245771646 TFRC/SUPT6H/HSPD1 3 GO:0006778 porphyrin-containing compound metabolic process 3/770 49/18722 0.32749705562592 0.658777245771646 HMOX1/ALAS1/EIF2AK1 3 GO:0009395 phospholipid catabolic process 3/770 49/18722 0.32749705562592 0.658777245771646 PNPLA8/LDLR/PRDX6 3 GO:0030195 negative regulation of blood coagulation 3/770 49/18722 0.32749705562592 0.658777245771646 SERPINB2/SERPINE1/C1QTNF1 3 GO:0030857 negative regulation of epithelial cell differentiation 3/770 49/18722 0.32749705562592 0.658777245771646 TBX3/HES1/CTNNB1 3 GO:0035088 establishment or maintenance of apical/basal cell polarity 3/770 49/18722 0.32749705562592 0.658777245771646 ARF4/OPHN1/DLG5 3 GO:0042304 regulation of fatty acid biosynthetic process 3/770 49/18722 0.32749705562592 0.658777245771646 ANXA1/ACADVL/INSIG1 3 GO:0045190 isotype switching 3/770 49/18722 0.32749705562592 0.658777245771646 TFRC/SUPT6H/HSPD1 3 GO:0046580 negative regulation of Ras protein signal transduction 3/770 49/18722 0.32749705562592 0.658777245771646 RASA1/ARHGAP24/KANK1 3 GO:0051445 regulation of meiotic cell cycle 3/770 49/18722 0.32749705562592 0.658777245771646 UBE2B/OVOL1/CALR 3 GO:0060964 regulation of gene silencing by miRNA 3/770 49/18722 0.32749705562592 0.658777245771646 EGFR/NEAT1/AGO2 3 GO:0061245 establishment or maintenance of bipolar cell polarity 3/770 49/18722 0.32749705562592 0.658777245771646 ARF4/OPHN1/DLG5 3 GO:0070169 positive regulation of biomineral tissue development 3/770 49/18722 0.32749705562592 0.658777245771646 CEBPB/TFAP2A/SLC4A2 3 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 3/770 49/18722 0.32749705562592 0.658777245771646 ERN1/P2RY6/MDM2 3 GO:1990928 response to amino acid starvation 3/770 49/18722 0.32749705562592 0.658777245771646 ATF3/MAP1LC3A/RRAGC 3 GO:0031058 positive regulation of histone modification 5/770 92/18722 0.327958719365799 0.658777245771646 GATA3/LMNA/CTNNB1/RPS6KA5/BRD4 5 GO:0022904 respiratory electron transport chain 6/770 114/18722 0.328214324502761 0.658777245771646 NDUFA6/COX6C/COX4I1/GHITM/COX6A1/NDUFB9 6 GO:0046488 phosphatidylinositol metabolic process 8/770 159/18722 0.331229392965785 0.658777245771646 PIK3C2A/MTMR10/SOCS1/TTC7B/SH3YL1/PI4K2A/SYNJ1/TMEM150A 8 GO:0007266 Rho protein signal transduction 7/770 137/18722 0.333722067310783 0.658777245771646 EPS8L1/GNA12/OPHN1/CDC42EP4/ADGRG1/KANK1/NRP1 7 GO:0060048 cardiac muscle contraction 7/770 137/18722 0.333722067310783 0.658777245771646 NEDD4L/DSP/EHD3/AKAP9/JUP/SLC9A1/PPP1R13L 7 GO:0090090 negative regulation of canonical Wnt signaling pathway 7/770 137/18722 0.333722067310783 0.658777245771646 DAB2/SIAH2/DDIT3/GLI3/LATS2/CSNK1A1/GPC3 7 GO:0003208 cardiac ventricle morphogenesis 4/770 71/18722 0.334406104229222 0.658777245771646 GATA3/DSP/PPP1R13L/TGFBR3 4 GO:0032722 positive regulation of chemokine production 4/770 71/18722 0.334406104229222 0.658777245771646 HMOX1/APP/DDX3X/LRP1 4 GO:0061515 myeloid cell development 4/770 71/18722 0.334406104229222 0.658777245771646 ALAS1/APP/BPGM/PAFAH1B1 4 GO:0000077 DNA damage checkpoint signaling 6/770 115/18722 0.335537121580004 0.658777245771646 FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 6 GO:0043279 response to alkaloid 6/770 115/18722 0.335537121580004 0.658777245771646 TGM2/MAP1LC3A/GHR/HSPA5/MDM2/HSPD1 6 GO:0071675 regulation of mononuclear cell migration 6/770 115/18722 0.335537121580004 0.658777245771646 APP/SERPINE1/CD200/WASL/AKIRIN1/CALR 6 GO:0019217 regulation of fatty acid metabolic process 5/770 93/18722 0.336140867049329 0.658777245771646 ANXA1/PPARD/IRS2/ACADVL/INSIG1 5 GO:0090398 cellular senescence 5/770 93/18722 0.336140867049329 0.658777245771646 TBX3/ARG2/ID2/CDK2/CALR 5 GO:0106027 neuron projection organization 5/770 93/18722 0.336140867049329 0.658777245771646 APP/DHX36/WASL/ARF1/PAFAH1B1 5 GO:0000305 response to oxygen radical 2/770 29/18722 0.336215523847529 0.658777245771646 SOD1/NFE2L2 2 GO:0002068 glandular epithelial cell development 2/770 29/18722 0.336215523847529 0.658777245771646 PDPK1/RHEB 2 GO:0002360 T cell lineage commitment 2/770 29/18722 0.336215523847529 0.658777245771646 CTSL/BCL2 2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/770 29/18722 0.336215523847529 0.658777245771646 FURIN/PSMB4 2 GO:0003309 type B pancreatic cell differentiation 2/770 29/18722 0.336215523847529 0.658777245771646 PDPK1/RHEB 2 GO:0006656 phosphatidylcholine biosynthetic process 2/770 29/18722 0.336215523847529 0.658777245771646 ABHD3/SLC44A1 2 GO:0010458 exit from mitosis 2/770 29/18722 0.336215523847529 0.658777245771646 CHMP4B/CHMP2A 2 GO:0015868 purine ribonucleotide transport 2/770 29/18722 0.336215523847529 0.658777245771646 SLC19A1/SLC25A5 2 GO:0019082 viral protein processing 2/770 29/18722 0.336215523847529 0.658777245771646 ST3GAL4/FURIN 2 GO:0019433 triglyceride catabolic process 2/770 29/18722 0.336215523847529 0.658777245771646 ABHD5/PNPLA2 2 GO:0021772 olfactory bulb development 2/770 29/18722 0.336215523847529 0.658777245771646 ID2/DLX5 2 GO:0022011 myelination in peripheral nervous system 2/770 29/18722 0.336215523847529 0.658777245771646 ITGB4/SOD1 2 GO:0031069 hair follicle morphogenesis 2/770 29/18722 0.336215523847529 0.658777245771646 BCL2/CTNNB1 2 GO:0032292 peripheral nervous system axon ensheathment 2/770 29/18722 0.336215523847529 0.658777245771646 ITGB4/SOD1 2 GO:0035066 positive regulation of histone acetylation 2/770 29/18722 0.336215523847529 0.658777245771646 GATA3/RPS6KA5 2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2/770 29/18722 0.336215523847529 0.658777245771646 EGFR/CCND3 2 GO:0050686 negative regulation of mRNA processing 2/770 29/18722 0.336215523847529 0.658777245771646 SAP18/RBM42 2 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 2/770 29/18722 0.336215523847529 0.658777245771646 SEMA6A/CD63 2 GO:0001961 positive regulation of cytokine-mediated signaling pathway 3/770 50/18722 0.338877108947252 0.658777245771646 HSPA1B/TBK1/PAFAH1B1 3 GO:0019083 viral transcription 3/770 50/18722 0.338877108947252 0.658777245771646 HEXIM1/GTF2B/PSMC3 3 GO:0050873 brown fat cell differentiation 3/770 50/18722 0.338877108947252 0.658777245771646 CEBPB/ARL4A/CEBPA 3 GO:0060688 regulation of morphogenesis of a branching structure 3/770 50/18722 0.338877108947252 0.658777245771646 LGR4/CTNNB1/MAP3K13 3 GO:0071709 membrane assembly 3/770 50/18722 0.338877108947252 0.658777245771646 CHMP4B/CHMP2A/UBE2I 3 GO:0071825 protein-lipid complex subunit organization 3/770 50/18722 0.338877108947252 0.658777245771646 ABCG1/SNX9/ARF1 3 GO:0110151 positive regulation of biomineralization 3/770 50/18722 0.338877108947252 0.658777245771646 CEBPB/TFAP2A/SLC4A2 3 GO:1900047 negative regulation of hemostasis 3/770 50/18722 0.338877108947252 0.658777245771646 SERPINB2/SERPINE1/C1QTNF1 3 GO:1902930 regulation of alcohol biosynthetic process 3/770 50/18722 0.338877108947252 0.658777245771646 P2RY6/ABCG1/SOD1 3 GO:0002819 regulation of adaptive immune response 9/770 183/18722 0.339906750898724 0.658777245771646 ANXA1/PRKCZ/TFRC/GATA3/CD55/CD274/CD46/SUPT6H/HSPD1 9 GO:0008016 regulation of heart contraction 10/770 206/18722 0.341553171395494 0.658777245771646 CYP2J2/HOPX/DSP/EPAS1/EHD3/AKAP9/JUP/MDM2/SLC9A1/ADM 10 GO:1903706 regulation of hemopoiesis 17/770 367/18722 0.342130143973353 0.658777245771646 ANXA1/PRKCZ/CSF3R/CEBPB/GATA3/SCIN/PNP/GLI3/NFKBIA/SOCS1/GATA2/ID2/CD46/CTNNB1/PRELID1/HSPA1B/SOD1 17 GO:0030518 intracellular steroid hormone receptor signaling pathway 6/770 116/18722 0.342878433426798 0.658777245771646 DAB2/UBR5/EGLN2/CALR/DNAJA1/UBA5 6 GO:0000098 sulfur amino acid catabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 CDO1 1 GO:0000255 allantoin metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 PNP 1 GO:0001672 regulation of chromatin assembly or disassembly 1/770 10/18722 0.343006311350895 0.658777245771646 TLK1 1 GO:0002524 hypersensitivity 1/770 10/18722 0.343006311350895 0.658777245771646 GATA3 1 GO:0002887 negative regulation of myeloid leukocyte mediated immunity 1/770 10/18722 0.343006311350895 0.658777245771646 HMOX1 1 GO:0003163 sinoatrial node development 1/770 10/18722 0.343006311350895 0.658777245771646 TBX3 1 GO:0005984 disaccharide metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 BRAF 1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 1/770 10/18722 0.343006311350895 0.658777245771646 GNAS 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/770 10/18722 0.343006311350895 0.658777245771646 AK3 1 GO:0009169 purine ribonucleoside monophosphate catabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 PNP 1 GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 PNP 1 GO:0009396 folic acid-containing compound biosynthetic process 1/770 10/18722 0.343006311350895 0.658777245771646 MTHFS 1 GO:0009750 response to fructose 1/770 10/18722 0.343006311350895 0.658777245771646 KRT18 1 GO:0009950 dorsal/ventral axis specification 1/770 10/18722 0.343006311350895 0.658777245771646 CTNNB1 1 GO:0010944 negative regulation of transcription by competitive promoter binding 1/770 10/18722 0.343006311350895 0.658777245771646 TFAP2A 1 GO:0010968 regulation of microtubule nucleation 1/770 10/18722 0.343006311350895 0.658777245771646 HSPA1B 1 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 1/770 10/18722 0.343006311350895 0.658777245771646 EIF2AK1 1 GO:0015696 ammonium transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC12A4 1 GO:0015808 L-alanine transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC3A2 1 GO:0019532 oxalate transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC26A2 1 GO:0019614 catechol-containing compound catabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 MAOA 1 GO:0021548 pons development 1/770 10/18722 0.343006311350895 0.658777245771646 BCL2 1 GO:0021562 vestibulocochlear nerve development 1/770 10/18722 0.343006311350895 0.658777245771646 NRP1 1 GO:0021903 rostrocaudal neural tube patterning 1/770 10/18722 0.343006311350895 0.658777245771646 HES1 1 GO:0030638 polyketide metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 AKR1B1 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 AKR1B1 1 GO:0031340 positive regulation of vesicle fusion 1/770 10/18722 0.343006311350895 0.658777245771646 ANXA1 1 GO:0031642 negative regulation of myelination 1/770 10/18722 0.343006311350895 0.658777245771646 TNFRSF21 1 GO:0033572 transferrin transport 1/770 10/18722 0.343006311350895 0.658777245771646 TFRC 1 GO:0035646 endosome to melanosome transport 1/770 10/18722 0.343006311350895 0.658777245771646 CD63 1 GO:0035871 protein K11-linked deubiquitination 1/770 10/18722 0.343006311350895 0.658777245771646 OTUB2 1 GO:0035999 tetrahydrofolate interconversion 1/770 10/18722 0.343006311350895 0.658777245771646 MTHFS 1 GO:0036363 transforming growth factor beta activation 1/770 10/18722 0.343006311350895 0.658777245771646 FURIN 1 GO:0040015 negative regulation of multicellular organism growth 1/770 10/18722 0.343006311350895 0.658777245771646 GDF15 1 GO:0042424 catecholamine catabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 MAOA 1 GO:0042989 sequestering of actin monomers 1/770 10/18722 0.343006311350895 0.658777245771646 SCIN 1 GO:0042996 regulation of Golgi to plasma membrane protein transport 1/770 10/18722 0.343006311350895 0.658777245771646 CLN3 1 GO:0043101 purine-containing compound salvage 1/770 10/18722 0.343006311350895 0.658777245771646 PNP 1 GO:0043485 endosome to pigment granule transport 1/770 10/18722 0.343006311350895 0.658777245771646 CD63 1 GO:0044557 relaxation of smooth muscle 1/770 10/18722 0.343006311350895 0.658777245771646 SOD1 1 GO:0044598 doxorubicin metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 AKR1B1 1 GO:0044848 biological phase 1/770 10/18722 0.343006311350895 0.658777245771646 CTNNB1 1 GO:0045625 regulation of T-helper 1 cell differentiation 1/770 10/18722 0.343006311350895 0.658777245771646 ANXA1 1 GO:0045792 negative regulation of cell size 1/770 10/18722 0.343006311350895 0.658777245771646 AKT1S1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/770 10/18722 0.343006311350895 0.658777245771646 PSMC6 1 GO:0048194 Golgi vesicle budding 1/770 10/18722 0.343006311350895 0.658777245771646 TMED9 1 GO:0048280 vesicle fusion with Golgi apparatus 1/770 10/18722 0.343006311350895 0.658777245771646 STX5 1 GO:0048672 positive regulation of collateral sprouting 1/770 10/18722 0.343006311350895 0.658777245771646 LRP1 1 GO:0048703 embryonic viscerocranium morphogenesis 1/770 10/18722 0.343006311350895 0.658777245771646 RDH10 1 GO:0048755 branching morphogenesis of a nerve 1/770 10/18722 0.343006311350895 0.658777245771646 MAP3K13 1 GO:0048757 pigment granule maturation 1/770 10/18722 0.343006311350895 0.658777245771646 CD63 1 GO:0051006 positive regulation of lipoprotein lipase activity 1/770 10/18722 0.343006311350895 0.658777245771646 ABHD5 1 GO:0051918 negative regulation of fibrinolysis 1/770 10/18722 0.343006311350895 0.658777245771646 SERPINE1 1 GO:0060272 embryonic skeletal joint morphogenesis 1/770 10/18722 0.343006311350895 0.658777245771646 CTNNB1 1 GO:0060439 trachea morphogenesis 1/770 10/18722 0.343006311350895 0.658777245771646 CTNNB1 1 GO:0060923 cardiac muscle cell fate commitment 1/770 10/18722 0.343006311350895 0.658777245771646 TBX3 1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 1/770 10/18722 0.343006311350895 0.658777245771646 PIM3 1 GO:0061299 retina vasculature morphogenesis in camera-type eye 1/770 10/18722 0.343006311350895 0.658777245771646 NRP1 1 GO:0070091 glucagon secretion 1/770 10/18722 0.343006311350895 0.658777245771646 SYT7 1 GO:0070092 regulation of glucagon secretion 1/770 10/18722 0.343006311350895 0.658777245771646 SYT7 1 GO:0071233 cellular response to leucine 1/770 10/18722 0.343006311350895 0.658777245771646 UBR1 1 GO:0072203 cell proliferation involved in metanephros development 1/770 10/18722 0.343006311350895 0.658777245771646 GPC3 1 GO:0072378 blood coagulation, fibrin clot formation 1/770 10/18722 0.343006311350895 0.658777245771646 FBLN1 1 GO:0072488 ammonium transmembrane transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC12A4 1 GO:0090043 regulation of tubulin deacetylation 1/770 10/18722 0.343006311350895 0.658777245771646 BEX4 1 GO:0090179 planar cell polarity pathway involved in neural tube closure 1/770 10/18722 0.343006311350895 0.658777245771646 DVL3 1 GO:0090647 modulation of age-related behavioral decline 1/770 10/18722 0.343006311350895 0.658777245771646 APP 1 GO:0097250 mitochondrial respirasome assembly 1/770 10/18722 0.343006311350895 0.658777245771646 HIGD1A 1 GO:0099532 synaptic vesicle endosomal processing 1/770 10/18722 0.343006311350895 0.658777245771646 EEA1 1 GO:0140059 dendrite arborization 1/770 10/18722 0.343006311350895 0.658777245771646 NRP1 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/770 10/18722 0.343006311350895 0.658777245771646 LDLR 1 GO:1901203 positive regulation of extracellular matrix assembly 1/770 10/18722 0.343006311350895 0.658777245771646 PHLDB2 1 GO:1901524 regulation of mitophagy 1/770 10/18722 0.343006311350895 0.658777245771646 SLC25A5 1 GO:1901993 regulation of meiotic cell cycle phase transition 1/770 10/18722 0.343006311350895 0.658777245771646 OVOL1 1 GO:1902023 L-arginine transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC38A9 1 GO:1903826 arginine transmembrane transport 1/770 10/18722 0.343006311350895 0.658777245771646 SLC38A9 1 GO:1904338 regulation of dopaminergic neuron differentiation 1/770 10/18722 0.343006311350895 0.658777245771646 CSNK1E 1 GO:1904668 positive regulation of ubiquitin protein ligase activity 1/770 10/18722 0.343006311350895 0.658777245771646 SKP1 1 GO:1905383 protein localization to presynapse 1/770 10/18722 0.343006311350895 0.658777245771646 HSPB1 1 GO:1990535 neuron projection maintenance 1/770 10/18722 0.343006311350895 0.658777245771646 APP 1 GO:2000121 regulation of removal of superoxide radicals 1/770 10/18722 0.343006311350895 0.658777245771646 NFE2L2 1 GO:2000425 regulation of apoptotic cell clearance 1/770 10/18722 0.343006311350895 0.658777245771646 TGM2 1 GO:2000434 regulation of protein neddylation 1/770 10/18722 0.343006311350895 0.658777245771646 EPAS1 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/770 10/18722 0.343006311350895 0.658777245771646 CALR 1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 1/770 10/18722 0.343006311350895 0.658777245771646 WASL 1 GO:2000674 regulation of type B pancreatic cell apoptotic process 1/770 10/18722 0.343006311350895 0.658777245771646 CAST 1 GO:2001223 negative regulation of neuron migration 1/770 10/18722 0.343006311350895 0.658777245771646 ADGRG1 1 GO:2001225 regulation of chloride transport 1/770 10/18722 0.343006311350895 0.658777245771646 GABRE 1 GO:0061448 connective tissue development 12/770 252/18722 0.343168914618953 0.658777245771646 ARID5B/PGRMC2/ARRDC3/SCIN/ANXA6/GLI3/GHR/CREB3L2/PPARD/TRIP11/CTNNB1/EFEMP1 12 GO:0000271 polysaccharide biosynthetic process 4/770 72/18722 0.343827782596898 0.658777245771646 AP2A1/IRS2/SORBS1/PPP1CB 4 GO:0001736 establishment of planar polarity 4/770 72/18722 0.343827782596898 0.658777245771646 DAB2/DVL3/GPC3/PAFAH1B1 4 GO:0007164 establishment of tissue polarity 4/770 72/18722 0.343827782596898 0.658777245771646 DAB2/DVL3/GPC3/PAFAH1B1 4 GO:0035567 non-canonical Wnt signaling pathway 4/770 72/18722 0.343827782596898 0.658777245771646 DAB2/DVL3/CSNK1E/GPC3 4 GO:0042246 tissue regeneration 4/770 72/18722 0.343827782596898 0.658777245771646 ANXA1/HOPX/PPARD/AKIRIN1 4 GO:0050709 negative regulation of protein secretion 4/770 72/18722 0.343827782596898 0.658777245771646 ANXA1/PIM3/CD200/RAB11FIP1 4 GO:1901880 negative regulation of protein depolymerization 4/770 72/18722 0.343827782596898 0.658777245771646 SCIN/ATXN7/CAMSAP2/TAOK1 4 GO:0019080 viral gene expression 5/770 94/18722 0.344339650641138 0.658777245771646 ST3GAL4/HEXIM1/FURIN/GTF2B/PSMC3 5 GO:0030316 osteoclast differentiation 5/770 94/18722 0.344339650641138 0.658777245771646 TFRC/CEBPB/CTNNB1/GPC3/PAFAH1B1 5 GO:0048704 embryonic skeletal system morphogenesis 5/770 94/18722 0.344339650641138 0.658777245771646 TFAP2A/GLI3/CTNNB1/EIF4A3/RDH10 5 GO:0043010 camera-type eye development 15/770 322/18722 0.347494335839073 0.658777245771646 GATA3/TFAP2A/RDH13/GLI3/LIMK2/TENM3/TBC1D20/CLN8/KDM5B/CTNNB1/PPP1R13L/RDH10/NRP1/SERPINF1/EFEMP1 15 GO:0034612 response to tumor necrosis factor 12/770 253/18722 0.348120190909357 0.658777245771646 GATA3/NFKBIA/KRT18/KRT8/CEBPA/TNFRSF21/ZFAND6/TANK/HSPA1B/COMMD7/ACTN4/NFE2L2 12 GO:0014902 myotube differentiation 6/770 117/18722 0.350235407091487 0.658777245771646 ERVFRD-1/GDF15/ERVW-1/BCL2/HDAC5/MYOF 6 GO:0006636 unsaturated fatty acid biosynthetic process 3/770 51/18722 0.350244388760076 0.658777245771646 ANXA1/PNPLA8/MIF 3 GO:0010874 regulation of cholesterol efflux 3/770 51/18722 0.350244388760076 0.658777245771646 NFKBIA/ABCG1/LRP1 3 GO:0032964 collagen biosynthetic process 3/770 51/18722 0.350244388760076 0.658777245771646 PPARD/SUCO/ERRFI1 3 GO:0051293 establishment of spindle localization 3/770 51/18722 0.350244388760076 0.658777245771646 SPIRE2/NUMA1/PAFAH1B1 3 GO:0051339 regulation of lyase activity 3/770 51/18722 0.350244388760076 0.658777245771646 GPR87/AKAP9/CAP2 3 GO:1903307 positive regulation of regulated secretory pathway 3/770 51/18722 0.350244388760076 0.658777245771646 GATA2/SYT7/ARF1 3 GO:0000132 establishment of mitotic spindle orientation 2/770 30/18722 0.351363482326568 0.658777245771646 NUMA1/PAFAH1B1 2 GO:0003299 muscle hypertrophy in response to stress 2/770 30/18722 0.351363482326568 0.658777245771646 LMNA/ERRFI1 2 GO:0007202 activation of phospholipase C activity 2/770 30/18722 0.351363482326568 0.658777245771646 EGFR/P2RY6 2 GO:0008209 androgen metabolic process 2/770 30/18722 0.351363482326568 0.658777245771646 CYP19A1/ADM 2 GO:0014887 cardiac muscle adaptation 2/770 30/18722 0.351363482326568 0.658777245771646 LMNA/ERRFI1 2 GO:0014898 cardiac muscle hypertrophy in response to stress 2/770 30/18722 0.351363482326568 0.658777245771646 LMNA/ERRFI1 2 GO:0015865 purine nucleotide transport 2/770 30/18722 0.351363482326568 0.658777245771646 SLC19A1/SLC25A5 2 GO:0017145 stem cell division 2/770 30/18722 0.351363482326568 0.658777245771646 NCOA3/PAFAH1B1 2 GO:0034694 response to prostaglandin 2/770 30/18722 0.351363482326568 0.658777245771646 P2RY6/TGFBR3 2 GO:0036296 response to increased oxygen levels 2/770 30/18722 0.351363482326568 0.658777245771646 ATP6V1G1/ATP6V0D1 2 GO:0045939 negative regulation of steroid metabolic process 2/770 30/18722 0.351363482326568 0.658777245771646 INSIG1/SOD1 2 GO:0048799 animal organ maturation 2/770 30/18722 0.351363482326568 0.658777245771646 GATA3/PHOSPHO1 2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 2/770 30/18722 0.351363482326568 0.658777245771646 EZR/DUSP3 2 GO:0051968 positive regulation of synaptic transmission, glutamatergic 2/770 30/18722 0.351363482326568 0.658777245771646 KMO/EGFR 2 GO:0060218 hematopoietic stem cell differentiation 2/770 30/18722 0.351363482326568 0.658777245771646 CHD2/NFE2L2 2 GO:0060603 mammary gland duct morphogenesis 2/770 30/18722 0.351363482326568 0.658777245771646 TBX3/KDM5B 2 GO:0060674 placenta blood vessel development 2/770 30/18722 0.351363482326568 0.658777245771646 SPINT1/HES1 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/770 30/18722 0.351363482326568 0.658777245771646 ARG2/IRS2 2 GO:0090314 positive regulation of protein targeting to membrane 2/770 30/18722 0.351363482326568 0.658777245771646 TCAF1/STOM 2 GO:2000637 positive regulation of gene silencing by miRNA 2/770 30/18722 0.351363482326568 0.658777245771646 EGFR/AGO2 2 GO:2000648 positive regulation of stem cell proliferation 2/770 30/18722 0.351363482326568 0.658777245771646 TBX3/FERMT2 2 GO:0006942 regulation of striated muscle contraction 5/770 95/18722 0.35255115894539 0.658777245771646 DSP/EHD3/AKAP9/JUP/SLC9A1 5 GO:0008593 regulation of Notch signaling pathway 5/770 95/18722 0.35255115894539 0.658777245771646 HES1/AAK1/NFKBIA/GATA2/CD46 5 GO:0032479 regulation of type I interferon production 5/770 95/18722 0.35255115894539 0.658777245771646 DHX36/DDX3X/TBK1/HSP90AA1/HSPD1 5 GO:0032606 type I interferon production 5/770 95/18722 0.35255115894539 0.658777245771646 DHX36/DDX3X/TBK1/HSP90AA1/HSPD1 5 GO:0061035 regulation of cartilage development 4/770 73/18722 0.353255303525353 0.658777245771646 SCIN/GLI3/CTNNB1/EFEMP1 4 GO:0070988 demethylation 4/770 73/18722 0.353255303525353 0.658777245771646 UBE2B/GATA3/TET2/KDM5B 4 GO:0072089 stem cell proliferation 4/770 73/18722 0.353255303525353 0.658777245771646 TBX3/OVOL1/FBLN1/FERMT2 4 GO:1904427 positive regulation of calcium ion transmembrane transport 4/770 73/18722 0.353255303525353 0.658777245771646 EHD3/P2RY6/PDPK1/SLC9A1 4 GO:0046165 alcohol biosynthetic process 7/770 140/18722 0.353860142405579 0.658777245771646 AKR1B1/P2RY6/ISYNA1/ABCG1/IDI1/INSIG1/SOD1 7 GO:0006913 nucleocytoplasmic transport 14/770 301/18722 0.357048522391566 0.658777245771646 PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/MDM2/LMNA/PPP1R10/SUPT6H/IWS1/CALR/TNPO1/ALYREF 14 GO:0051169 nuclear transport 14/770 301/18722 0.357048522391566 0.658777245771646 PTTG1IP/GLI3/KPNA6/NFKBIA/JUP/UBR5/MDM2/LMNA/PPP1R10/SUPT6H/IWS1/CALR/TNPO1/ALYREF 14 GO:0007613 memory 6/770 118/18722 0.357605221636708 0.658777245771646 PRKCZ/SGK1/CEBPB/PAIP2/LDLR/SERPINF1 6 GO:0043547 positive regulation of GTPase activity 12/770 255/18722 0.358059710322813 0.658777245771646 RASA1/TGM2/EIF5/TBC1D9/ARHGAP24/DVL3/TBC1D20/SNX9/RAPGEF1/RABGAP1/CDKL5/FERMT2 12 GO:0030183 B cell differentiation 7/770 141/18722 0.360600961907294 0.658777245771646 BCL2/HDAC5/ID2/DNAJB9/SLC25A5/TPD52/FNIP1 7 GO:0030510 regulation of BMP signaling pathway 5/770 96/18722 0.360771547006914 0.658777245771646 GREM2/HES1/CRIM1/NUMA1/GPC3 5 GO:0044264 cellular polysaccharide metabolic process 5/770 96/18722 0.360771547006914 0.658777245771646 PHLDA2/STK40/IRS2/SORBS1/PPP1CB 5 GO:0002218 activation of innate immune response 3/770 52/18722 0.361589614375932 0.658777245771646 HEXIM1/TBK1/HSP90AA1 3 GO:0034204 lipid translocation 3/770 52/18722 0.361589614375932 0.658777245771646 ATP10D/KCNN4/ABCG1 3 GO:0035196 production of miRNAs involved in gene silencing by miRNA 3/770 52/18722 0.361589614375932 0.658777245771646 EGFR/DDX3X/AGO2 3 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 3/770 52/18722 0.361589614375932 0.658777245771646 DAB2/DVL3/GPC3 3 GO:0060147 regulation of posttranscriptional gene silencing 3/770 52/18722 0.361589614375932 0.658777245771646 EGFR/NEAT1/AGO2 3 GO:1903426 regulation of reactive oxygen species biosynthetic process 3/770 52/18722 0.361589614375932 0.658777245771646 ARG2/CLCN3/HSPD1 3 GO:2000378 negative regulation of reactive oxygen species metabolic process 3/770 52/18722 0.361589614375932 0.658777245771646 TFAP2A/BCL2/HSPD1 3 GO:0050680 negative regulation of epithelial cell proliferation 8/770 164/18722 0.362327607407885 0.658777245771646 NUPR1/CDKN1C/GATA3/MTSS1/PPARD/GPC3/SERPINF1/TGFBR3 8 GO:1902105 regulation of leukocyte differentiation 13/770 279/18722 0.362424917078466 0.658777245771646 ANXA1/PRKCZ/CEBPB/GATA3/PNP/GLI3/SOCS1/GATA2/ID2/CD46/CTNNB1/PRELID1/SOD1 13 GO:0046470 phosphatidylcholine metabolic process 4/770 74/18722 0.362683033885264 0.658777245771646 ABHD3/PNPLA8/LDLR/SLC44A1 4 GO:0048844 artery morphogenesis 4/770 74/18722 0.362683033885264 0.658777245771646 HES1/LDLR/LRP1/NRP1 4 GO:0120192 tight junction assembly 4/770 74/18722 0.362683033885264 0.658777245771646 CLDN7/LSR/MPP7/CLDN4 4 GO:0033044 regulation of chromosome organization 9/770 187/18722 0.363219496484592 0.658777245771646 NEK7/DHX36/PKIB/TNKS2/XRN1/NUMA1/PPP1R10/CTNNB1/MAP3K4 9 GO:0030282 bone mineralization 6/770 119/18722 0.36498509046092 0.658777245771646 TFAP2A/LGR4/PHOSPHO1/SBDS/TUFT1/GPC3 6 GO:0007190 activation of adenylate cyclase activity 2/770 31/18722 0.36638993700264 0.658777245771646 LGR4/CAP2 2 GO:0008045 motor neuron axon guidance 2/770 31/18722 0.36638993700264 0.658777245771646 LAMC2/NRP1 2 GO:0016577 histone demethylation 2/770 31/18722 0.36638993700264 0.658777245771646 UBE2B/KDM5B 2 GO:0030149 sphingolipid catabolic process 2/770 31/18722 0.36638993700264 0.658777245771646 NEU1/GLA 2 GO:0030201 heparan sulfate proteoglycan metabolic process 2/770 31/18722 0.36638993700264 0.658777245771646 GLCE/CTNNB1 2 GO:0030212 hyaluronan metabolic process 2/770 31/18722 0.36638993700264 0.658777245771646 AP2A1/ITIH5 2 GO:0032148 activation of protein kinase B activity 2/770 31/18722 0.36638993700264 0.658777245771646 PRKCZ/PDPK1 2 GO:0035510 DNA dealkylation 2/770 31/18722 0.36638993700264 0.658777245771646 GATA3/TET2 2 GO:0042133 neurotransmitter metabolic process 2/770 31/18722 0.36638993700264 0.658777245771646 CLN3/MAOA 2 GO:0045066 regulatory T cell differentiation 2/770 31/18722 0.36638993700264 0.658777245771646 SOCS1/CD46 2 GO:0048566 embryonic digestive tract development 2/770 31/18722 0.36638993700264 0.658777245771646 GLI3/ID2 2 GO:0050482 arachidonic acid secretion 2/770 31/18722 0.36638993700264 0.658777245771646 ANXA1/PNPLA8 2 GO:0051443 positive regulation of ubiquitin-protein transferase activity 2/770 31/18722 0.36638993700264 0.658777245771646 ARRDC3/SKP1 2 GO:0051569 regulation of histone H3-K4 methylation 2/770 31/18722 0.36638993700264 0.658777245771646 GATA3/CTNNB1 2 GO:0060055 angiogenesis involved in wound healing 2/770 31/18722 0.36638993700264 0.658777245771646 SERPINE1/GATA2 2 GO:0060148 positive regulation of posttranscriptional gene silencing 2/770 31/18722 0.36638993700264 0.658777245771646 EGFR/AGO2 2 GO:0060390 regulation of SMAD protein signal transduction 2/770 31/18722 0.36638993700264 0.658777245771646 DAB2/LRP1 2 GO:0065005 protein-lipid complex assembly 2/770 31/18722 0.36638993700264 0.658777245771646 SNX9/ARF1 2 GO:0070528 protein kinase C signaling 2/770 31/18722 0.36638993700264 0.658777245771646 PRKCZ/ADGRG1 2 GO:0071480 cellular response to gamma radiation 2/770 31/18722 0.36638993700264 0.658777245771646 HSPA5/MDM2 2 GO:0071711 basement membrane organization 2/770 31/18722 0.36638993700264 0.658777245771646 PHLDB2/SPINT2 2 GO:0090162 establishment of epithelial cell polarity 2/770 31/18722 0.36638993700264 0.658777245771646 HES1/OPHN1 2 GO:1903963 arachidonate transport 2/770 31/18722 0.36638993700264 0.658777245771646 ANXA1/PNPLA8 2 GO:0046467 membrane lipid biosynthetic process 7/770 142/18722 0.367352269788623 0.658777245771646 ST3GAL4/B3GNT5/SPTSSA/PLPP3/SAMD8/CLN8/ORMDL1 7 GO:0050867 positive regulation of cell activation 19/770 420/18722 0.367860010713605 0.658777245771646 ANXA1/PRKCZ/TFRC/GATA3/CD55/VAV3/PNP/HES1/BCL2/GLI3/SOCS1/CD274/JUND/GATA2/CEBPA/CD46/IRS2/MIF/HSPD1 19 GO:0033674 positive regulation of kinase activity 21/770 467/18722 0.368385865498198 0.658777245771646 PRKCZ/EGFR/VAV3/EPHB4/GHR/ERN1/SOCS1/DVL3/ERBB3/SNX9/PDPK1/SYAP1/DDX3X/RICTOR/PRLR/MAP3K13/MAP3K4/HSP90AA1/TAOK1/FERMT2/CCND3 21 GO:0070252 actin-mediated cell contraction 5/770 97/18722 0.368997039254788 0.658777245771646 NEDD4L/DSP/AKAP9/JUP/SLC9A1 5 GO:0050807 regulation of synapse organization 10/770 211/18722 0.369060627690831 0.658777245771646 APP/VCP/DHX36/ARF4/CLN3/DLG5/CHMP2B/PAFAH1B1/CDKL5/HSPA8 10 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/770 11/18722 0.370041643771791 0.658777245771646 ERN1 1 GO:0001967 suckling behavior 1/770 11/18722 0.370041643771791 0.658777245771646 APP 1 GO:0002327 immature B cell differentiation 1/770 11/18722 0.370041643771791 0.658777245771646 FNIP1 1 GO:0002645 positive regulation of tolerance induction 1/770 11/18722 0.370041643771791 0.658777245771646 CD274 1 GO:0002732 positive regulation of dendritic cell cytokine production 1/770 11/18722 0.370041643771791 0.658777245771646 DHX36 1 GO:0006020 inositol metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 ISYNA1 1 GO:0006054 N-acetylneuraminate metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 CMAS 1 GO:0006449 regulation of translational termination 1/770 11/18722 0.370041643771791 0.658777245771646 ETF1 1 GO:0006527 arginine catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 ARG2 1 GO:0006568 tryptophan metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 KMO 1 GO:0009120 deoxyribonucleoside metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0009128 purine nucleoside monophosphate catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0009155 purine deoxyribonucleotide catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0009313 oligosaccharide catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 NEU1 1 GO:0010269 response to selenium ion 1/770 11/18722 0.370041643771791 0.658777245771646 MIEN1 1 GO:0010739 positive regulation of protein kinase A signaling 1/770 11/18722 0.370041643771791 0.658777245771646 MIF 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/770 11/18722 0.370041643771791 0.658777245771646 VCP 1 GO:0014854 response to inactivity 1/770 11/18722 0.370041643771791 0.658777245771646 FBXO32 1 GO:0015886 heme transport 1/770 11/18722 0.370041643771791 0.658777245771646 PGRMC2 1 GO:0015937 coenzyme A biosynthetic process 1/770 11/18722 0.370041643771791 0.658777245771646 SLC25A16 1 GO:0021561 facial nerve development 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:0021604 cranial nerve structural organization 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:0021610 facial nerve morphogenesis 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:0021889 olfactory bulb interneuron differentiation 1/770 11/18722 0.370041643771791 0.658777245771646 DLX5 1 GO:0030210 heparin biosynthetic process 1/770 11/18722 0.370041643771791 0.658777245771646 GLCE 1 GO:0030432 peristalsis 1/770 11/18722 0.370041643771791 0.658777245771646 TBX3 1 GO:0030656 regulation of vitamin metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 RDH10 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/770 11/18722 0.370041643771791 0.658777245771646 DHX36 1 GO:0032000 positive regulation of fatty acid beta-oxidation 1/770 11/18722 0.370041643771791 0.658777245771646 IRS2 1 GO:0032329 serine transport 1/770 11/18722 0.370041643771791 0.658777245771646 SERINC5 1 GO:0032957 inositol trisphosphate metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 P2RY6 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/770 11/18722 0.370041643771791 0.658777245771646 BCL2 1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1/770 11/18722 0.370041643771791 0.658777245771646 ACADVL 1 GO:0034379 very-low-density lipoprotein particle assembly 1/770 11/18722 0.370041643771791 0.658777245771646 ARF1 1 GO:0034454 microtubule anchoring at centrosome 1/770 11/18722 0.370041643771791 0.658777245771646 HOOK3 1 GO:0034650 cortisol metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 CYP11A1 1 GO:0035404 histone-serine phosphorylation 1/770 11/18722 0.370041643771791 0.658777245771646 RPS6KA5 1 GO:0035457 cellular response to interferon-alpha 1/770 11/18722 0.370041643771791 0.658777245771646 GATA3 1 GO:0035865 cellular response to potassium ion 1/770 11/18722 0.370041643771791 0.658777245771646 SOD1 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/770 11/18722 0.370041643771791 0.658777245771646 DDX3X 1 GO:0042135 neurotransmitter catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 MAOA 1 GO:0042167 heme catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 HMOX1 1 GO:0042447 hormone catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 CYP19A1 1 GO:0042451 purine nucleoside biosynthetic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0042455 ribonucleoside biosynthetic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0042789 mRNA transcription by RNA polymerase II 1/770 11/18722 0.370041643771791 0.658777245771646 SUPT6H 1 GO:0043312 neutrophil degranulation 1/770 11/18722 0.370041643771791 0.658777245771646 STXBP3 1 GO:0044068 modulation by symbiont of host cellular process 1/770 11/18722 0.370041643771791 0.658777245771646 SERPINB9 1 GO:0044771 meiotic cell cycle phase transition 1/770 11/18722 0.370041643771791 0.658777245771646 OVOL1 1 GO:0045060 negative thymic T cell selection 1/770 11/18722 0.370041643771791 0.658777245771646 GLI3 1 GO:0045161 neuronal ion channel clustering 1/770 11/18722 0.370041643771791 0.658777245771646 GLDN 1 GO:0045945 positive regulation of transcription by RNA polymerase III 1/770 11/18722 0.370041643771791 0.658777245771646 CEBPA 1 GO:0046129 purine ribonucleoside biosynthetic process 1/770 11/18722 0.370041643771791 0.658777245771646 PNP 1 GO:0046149 pigment catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 HMOX1 1 GO:0046598 positive regulation of viral entry into host cell 1/770 11/18722 0.370041643771791 0.658777245771646 P4HB 1 GO:0046710 GDP metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 MPP1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/770 11/18722 0.370041643771791 0.658777245771646 RAP1B 1 GO:0048096 chromatin-mediated maintenance of transcription 1/770 11/18722 0.370041643771791 0.658777245771646 SERTAD1 1 GO:0048680 positive regulation of axon regeneration 1/770 11/18722 0.370041643771791 0.658777245771646 LRP1 1 GO:0051081 nuclear membrane disassembly 1/770 11/18722 0.370041643771791 0.658777245771646 PAFAH1B1 1 GO:0051561 positive regulation of mitochondrial calcium ion concentration 1/770 11/18722 0.370041643771791 0.658777245771646 TGM2 1 GO:0051574 positive regulation of histone H3-K9 methylation 1/770 11/18722 0.370041643771791 0.658777245771646 LMNA 1 GO:0051798 positive regulation of hair follicle development 1/770 11/18722 0.370041643771791 0.658777245771646 NUMA1 1 GO:0055015 ventricular cardiac muscle cell development 1/770 11/18722 0.370041643771791 0.658777245771646 LMNA 1 GO:0060312 regulation of blood vessel remodeling 1/770 11/18722 0.370041643771791 0.658777245771646 TMBIM1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/770 11/18722 0.370041643771791 0.658777245771646 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/770 11/18722 0.370041643771791 0.658777245771646 GLI3 1 GO:0060742 epithelial cell differentiation involved in prostate gland development 1/770 11/18722 0.370041643771791 0.658777245771646 CTNNB1 1 GO:0060837 blood vessel endothelial cell differentiation 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:0060900 embryonic camera-type eye formation 1/770 11/18722 0.370041643771791 0.658777245771646 TFAP2A 1 GO:0061029 eyelid development in camera-type eye 1/770 11/18722 0.370041643771791 0.658777245771646 TFAP2A 1 GO:0061303 cornea development in camera-type eye 1/770 11/18722 0.370041643771791 0.658777245771646 LIMK2 1 GO:0061365 positive regulation of triglyceride lipase activity 1/770 11/18722 0.370041643771791 0.658777245771646 ABHD5 1 GO:0070189 kynurenine metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 KMO 1 GO:0070327 thyroid hormone transport 1/770 11/18722 0.370041643771791 0.658777245771646 SLC7A5 1 GO:0070341 fat cell proliferation 1/770 11/18722 0.370041643771791 0.658777245771646 GATA2 1 GO:0070344 regulation of fat cell proliferation 1/770 11/18722 0.370041643771791 0.658777245771646 GATA2 1 GO:0070601 centromeric sister chromatid cohesion 1/770 11/18722 0.370041643771791 0.658777245771646 CTNNB1 1 GO:0071044 histone mRNA catabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 XRN1 1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 1/770 11/18722 0.370041643771791 0.658777245771646 RER1 1 GO:0071679 commissural neuron axon guidance 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:0071888 macrophage apoptotic process 1/770 11/18722 0.370041643771791 0.658777245771646 CTSL 1 GO:0075294 positive regulation by symbiont of entry into host 1/770 11/18722 0.370041643771791 0.658777245771646 P4HB 1 GO:0075733 intracellular transport of virus 1/770 11/18722 0.370041643771791 0.658777245771646 KPNA6 1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1/770 11/18722 0.370041643771791 0.658777245771646 DVL3 1 GO:0090205 positive regulation of cholesterol metabolic process 1/770 11/18722 0.370041643771791 0.658777245771646 ABCG1 1 GO:0090394 negative regulation of excitatory postsynaptic potential 1/770 11/18722 0.370041643771791 0.658777245771646 EIF4A3 1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/770 11/18722 0.370041643771791 0.658777245771646 SLC35B4 1 GO:0090649 response to oxygen-glucose deprivation 1/770 11/18722 0.370041643771791 0.658777245771646 BNIP2 1 GO:0097050 type B pancreatic cell apoptotic process 1/770 11/18722 0.370041643771791 0.658777245771646 CAST 1 GO:0097499 protein localization to non-motile cilium 1/770 11/18722 0.370041643771791 0.658777245771646 ZDHHC3 1 GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 1/770 11/18722 0.370041643771791 0.658777245771646 OPHN1 1 GO:0106049 regulation of cellular response to osmotic stress 1/770 11/18722 0.370041643771791 0.658777245771646 CLN3 1 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/770 11/18722 0.370041643771791 0.658777245771646 ARRDC3 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/770 11/18722 0.370041643771791 0.658777245771646 LMNA 1 GO:1900222 negative regulation of amyloid-beta clearance 1/770 11/18722 0.370041643771791 0.658777245771646 LRPAP1 1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 1/770 11/18722 0.370041643771791 0.658777245771646 DDX3X 1 GO:1902667 regulation of axon guidance 1/770 11/18722 0.370041643771791 0.658777245771646 NRP1 1 GO:1903238 positive regulation of leukocyte tethering or rolling 1/770 11/18722 0.370041643771791 0.658777245771646 ST3GAL4 1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1/770 11/18722 0.370041643771791 0.658777245771646 HSPA1B 1 GO:1903423 positive regulation of synaptic vesicle recycling 1/770 11/18722 0.370041643771791 0.658777245771646 AP2M1 1 GO:1903961 positive regulation of anion transmembrane transport 1/770 11/18722 0.370041643771791 0.658777245771646 TCAF1 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/770 11/18722 0.370041643771791 0.658777245771646 CD200 1 GO:1905050 positive regulation of metallopeptidase activity 1/770 11/18722 0.370041643771791 0.658777245771646 CLDN4 1 GO:1905668 positive regulation of protein localization to endosome 1/770 11/18722 0.370041643771791 0.658777245771646 EZR 1 GO:1990773 matrix metallopeptidase secretion 1/770 11/18722 0.370041643771791 0.658777245771646 CD200 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/770 11/18722 0.370041643771791 0.658777245771646 LRP1 1 GO:2000392 regulation of lamellipodium morphogenesis 1/770 11/18722 0.370041643771791 0.658777245771646 KANK1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/770 11/18722 0.370041643771791 0.658777245771646 PKIB 1 GO:2000615 regulation of histone H3-K9 acetylation 1/770 11/18722 0.370041643771791 0.658777245771646 GATA3 1 GO:0002292 T cell differentiation involved in immune response 4/770 75/18722 0.372105495001737 0.661742213273966 ANXA1/PRKCZ/GATA3/CD46 4 GO:0006024 glycosaminoglycan biosynthetic process 4/770 75/18722 0.372105495001737 0.661742213273966 ST3GAL4/AP2A1/GLCE/CHPF 4 GO:0048662 negative regulation of smooth muscle cell proliferation 4/770 75/18722 0.372105495001737 0.661742213273966 HMOX1/PDCD4/GNA12/PPARD 4 GO:0048593 camera-type eye morphogenesis 6/770 120/18722 0.372372263495009 0.661745100312866 TFAP2A/RDH13/GLI3/TENM3/TBC1D20/CTNNB1 6 GO:0002707 negative regulation of lymphocyte mediated immunity 3/770 53/18722 0.372903921669381 0.661745100312866 CD55/SERPINB9/CD46 3 GO:0050819 negative regulation of coagulation 3/770 53/18722 0.372903921669381 0.661745100312866 SERPINB2/SERPINE1/C1QTNF1 3 GO:0060966 regulation of gene silencing by RNA 3/770 53/18722 0.372903921669381 0.661745100312866 EGFR/NEAT1/AGO2 3 GO:0097479 synaptic vesicle localization 3/770 53/18722 0.372903921669381 0.661745100312866 ARF1/CTNNB1/SYNJ1 3 GO:1903202 negative regulation of oxidative stress-induced cell death 3/770 53/18722 0.372903921669381 0.661745100312866 HSPB1/CTNNB1/NFE2L2 3 GO:0038061 NIK/NF-kappaB signaling 7/770 143/18722 0.374111951078621 0.663416317517712 PDCD4/EGFR/APP/NFKBIA/DDX3X/CALR/ACTN4 7 GO:0070555 response to interleukin-1 7/770 143/18722 0.374111951078621 0.663416317517712 ANXA1/KMO/CEBPB/APP/GHR/TANK/RPS6KA5 7 GO:0060538 skeletal muscle organ development 8/770 166/18722 0.374853008760094 0.664420045830271 NUPR1/MAFF/BASP1/ATF3/BCL2/AKIRIN1/CTNNB1/HMG20B 8 GO:0046578 regulation of Ras protein signal transduction 9/770 189/18722 0.374944645569882 0.664420045830271 SQSTM1/EPS8L1/RASA1/ARHGAP24/OPHN1/ADGRG1/KANK1/NRP1/LRRC59 9 GO:0032642 regulation of chemokine production 5/770 98/18722 0.377223932394753 0.664652873622864 HMOX1/ARG2/APP/DDX3X/LRP1 5 GO:0043473 pigmentation 5/770 98/18722 0.377223932394753 0.664652873622864 RAB11A/CD63/BCL2/GLI3/RAB1A 5 GO:0061337 cardiac conduction 5/770 98/18722 0.377223932394753 0.664652873622864 DSP/EHD3/AKAP9/JUP/SLC9A1 5 GO:0048738 cardiac muscle tissue development 11/770 236/18722 0.379192159096005 0.664652873622864 TBX3/HOPX/DSP/MSX2/ID2/NEBL/LMNA/CALR/SLC9A1/PPP1R13L/TGFBR3 11 GO:0051051 negative regulation of transport 21/770 470/18722 0.37955031564213 0.664652873622864 ANXA1/HMOX1/SLC43A2/NEDD4L/PIM3/BCL2/GABRE/CD200/DYSF/LRPAP1/RAP1B/ERBB3/ERLEC1/IRS2/VPS4B/RAB7A/STXBP3/UBQLN1/INSIG1/RAB11FIP1/COMMD1 21 GO:0002224 toll-like receptor signaling pathway 6/770 121/18722 0.379764029275148 0.664652873622864 LGR4/NFKBIA/PDPK1/DDX3X/COLEC12/HSPD1 6 GO:0010821 regulation of mitochondrion organization 7/770 144/18722 0.380877913161372 0.664652873622864 SQSTM1/TFRC/PMAIP1/SLC25A5/LMNA/PRELID1/GHITM 7 GO:0006026 aminoglycan catabolic process 2/770 32/18722 0.381279266201963 0.664652873622864 FUCA1/IDS 2 GO:0007435 salivary gland morphogenesis 2/770 32/18722 0.381279266201963 0.664652873622864 TGM2/NRP1 2 GO:0010743 regulation of macrophage derived foam cell differentiation 2/770 32/18722 0.381279266201963 0.664652873622864 NFKBIA/ABCG1 2 GO:0014044 Schwann cell development 2/770 32/18722 0.381279266201963 0.664652873622864 ITGB4/SOD1 2 GO:0035767 endothelial cell chemotaxis 2/770 32/18722 0.381279266201963 0.664652873622864 HSPB1/NRP1 2 GO:0042744 hydrogen peroxide catabolic process 2/770 32/18722 0.381279266201963 0.664652873622864 GPX3/PRDX6 2 GO:0046856 phosphatidylinositol dephosphorylation 2/770 32/18722 0.381279266201963 0.664652873622864 MTMR10/SYNJ1 2 GO:0051497 negative regulation of stress fiber assembly 2/770 32/18722 0.381279266201963 0.664652873622864 PHLDB2/PPFIA1 2 GO:0060323 head morphogenesis 2/770 32/18722 0.381279266201963 0.664652873622864 ARID5B/DLX5 2 GO:0060914 heart formation 2/770 32/18722 0.381279266201963 0.664652873622864 HES1/CTNNB1 2 GO:0061037 negative regulation of cartilage development 2/770 32/18722 0.381279266201963 0.664652873622864 CTNNB1/EFEMP1 2 GO:0072525 pyridine-containing compound biosynthetic process 2/770 32/18722 0.381279266201963 0.664652873622864 KMO/PDXK 2 GO:1900745 positive regulation of p38MAPK cascade 2/770 32/18722 0.381279266201963 0.664652873622864 GADD45G/MAP3K4 2 GO:1901889 negative regulation of cell junction assembly 2/770 32/18722 0.381279266201963 0.664652873622864 PHLDB2/LRP1 2 GO:0006809 nitric oxide biosynthetic process 4/770 76/18722 0.381517365723996 0.664652873622864 ARG2/GLA/DYNLL1/HSP90AA1 4 GO:0086001 cardiac muscle cell action potential 4/770 76/18722 0.381517365723996 0.664652873622864 NEDD4L/DSP/AKAP9/JUP 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/770 76/18722 0.381517365723996 0.664652873622864 EGFR/CLCN3/SOD1/NFE2L2 4 GO:0007215 glutamate receptor signaling pathway 3/770 54/18722 0.384178859619225 0.664652873622864 APP/CPEB4/CLN3 3 GO:0031050 dsRNA processing 3/770 54/18722 0.384178859619225 0.664652873622864 EGFR/DDX3X/AGO2 3 GO:0070918 production of small RNA involved in gene silencing by RNA 3/770 54/18722 0.384178859619225 0.664652873622864 EGFR/DDX3X/AGO2 3 GO:0072698 protein localization to microtubule cytoskeleton 3/770 54/18722 0.384178859619225 0.664652873622864 GOLGB1/HOOK3/NUMA1 3 GO:0086002 cardiac muscle cell action potential involved in contraction 3/770 54/18722 0.384178859619225 0.664652873622864 NEDD4L/DSP/JUP 3 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 3/770 54/18722 0.384178859619225 0.664652873622864 GATA3/GATA2/PPARD 3 GO:2000179 positive regulation of neural precursor cell proliferation 3/770 54/18722 0.384178859619225 0.664652873622864 GLI3/ADGRG1/CTNNB1 3 GO:1901361 organic cyclic compound catabolic process 22/770 495/18722 0.38487105809212 0.664652873622864 CYP19A1/HMOX1/KMO/PNP/ETF1/ERN1/VCP/DHX36/STS/RNASEH2C/DEDD2/MTHFS/LARP4B/TET2/RBM8A/MAOA/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2/NFE2L2 22 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 5/770 99/18722 0.385448598056934 0.664652873622864 NUPR1/HMOX1/BCL2/MIF/USP47 5 GO:0021510 spinal cord development 5/770 99/18722 0.385448598056934 0.664652873622864 GLI3/GATA2/CLN8/SCYL1/GIGYF2 5 GO:0032602 chemokine production 5/770 99/18722 0.385448598056934 0.664652873622864 HMOX1/ARG2/APP/DDX3X/LRP1 5 GO:0072330 monocarboxylic acid biosynthetic process 10/770 214/18722 0.385685126082614 0.664652873622864 ANXA1/KMO/ABHD3/ACSS1/PNPLA8/ACADVL/OSBP/RDH10/MIF/INSIG1 10 GO:0002706 regulation of lymphocyte mediated immunity 8/770 168/18722 0.387407313465395 0.664652873622864 PRKCZ/TFRC/GATA3/CD55/SERPINB9/CD46/SUPT6H/HSPD1 8 GO:0048644 muscle organ morphogenesis 4/770 77/18722 0.390913484974711 0.664652873622864 ARID5B/DSP/SERP1/TGFBR3 4 GO:0009062 fatty acid catabolic process 5/770 100/18722 0.393667485205608 0.664652873622864 ABHD3/PPARD/IRS2/ACADVL/AIG1 5 GO:0110020 regulation of actomyosin structure organization 5/770 100/18722 0.393667485205608 0.664652873622864 PHLDB2/PPFIA1/SLC9A1/NRP1/FERMT2 5 GO:0006937 regulation of muscle contraction 8/770 169/18722 0.3936911604989 0.664652873622864 DSP/ANXA6/EHD3/AKAP9/JUP/PPP1R12B/SLC9A1/SOD1 8 GO:0018394 peptidyl-lysine acetylation 8/770 169/18722 0.3936911604989 0.664652873622864 GATA3/NCOA3/MBD3/GATA2/DIP2B/GTF2B/IWS1/RPS6KA5 8 GO:0006690 icosanoid metabolic process 6/770 123/18722 0.39455069782683 0.664652873622864 ANXA1/CYP2J2/AKR1B1/PNPLA8/MGST3/MIF 6 GO:0031570 DNA integrity checkpoint signaling 6/770 123/18722 0.39455069782683 0.664652873622864 FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 6 GO:0050852 T cell receptor signaling pathway 6/770 123/18722 0.39455069782683 0.664652873622864 GATA3/EZR/KCNN4/TNFRSF21/DUSP3/EIF2B2 6 GO:0071482 cellular response to light stimulus 6/770 123/18722 0.39455069782683 0.664652873622864 MME/DHX36/OPN3/MDM2/DDB1/USP47 6 GO:0002067 glandular epithelial cell differentiation 3/770 55/18722 0.395406385814781 0.664652873622864 HES1/PDPK1/RHEB 3 GO:0006414 translational elongation 3/770 55/18722 0.395406385814781 0.664652873622864 SECISBP2L/EIF4A3/USP16 3 GO:0044091 membrane biogenesis 3/770 55/18722 0.395406385814781 0.664652873622864 CHMP4B/CHMP2A/UBE2I 3 GO:0051898 negative regulation of protein kinase B signaling 3/770 55/18722 0.395406385814781 0.664652873622864 DDIT3/PHLPP1/PDCD6 3 GO:0061614 pri-miRNA transcription by RNA polymerase II 3/770 55/18722 0.395406385814781 0.664652873622864 GATA3/GATA2/PPARD 3 GO:0001821 histamine secretion 1/770 12/18722 0.395965855962252 0.664652873622864 SNAP23 1 GO:0002424 T cell mediated immune response to tumor cell 1/770 12/18722 0.395965855962252 0.664652873622864 HSPD1 1 GO:0002664 regulation of T cell tolerance induction 1/770 12/18722 0.395965855962252 0.664652873622864 PHLPP1 1 GO:0002903 negative regulation of B cell apoptotic process 1/770 12/18722 0.395965855962252 0.664652873622864 IRS2 1 GO:0003306 Wnt signaling pathway involved in heart development 1/770 12/18722 0.395965855962252 0.664652873622864 CTNNB1 1 GO:0006534 cysteine metabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 CDO1 1 GO:0006563 L-serine metabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 SERINC5 1 GO:0006787 porphyrin-containing compound catabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 HMOX1 1 GO:0007614 short-term memory 1/770 12/18722 0.395965855962252 0.664652873622864 SERPINF1 1 GO:0009886 post-embryonic animal morphogenesis 1/770 12/18722 0.395965855962252 0.664652873622864 EFEMP1 1 GO:0010454 negative regulation of cell fate commitment 1/770 12/18722 0.395965855962252 0.664652873622864 HES1 1 GO:0010623 programmed cell death involved in cell development 1/770 12/18722 0.395965855962252 0.664652873622864 BCL2 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/770 12/18722 0.395965855962252 0.664652873622864 LRP1 1 GO:0015780 nucleotide-sugar transmembrane transport 1/770 12/18722 0.395965855962252 0.664652873622864 SLC35B4 1 GO:0016188 synaptic vesicle maturation 1/770 12/18722 0.395965855962252 0.664652873622864 CLCN3 1 GO:0016554 cytidine to uridine editing 1/770 12/18722 0.395965855962252 0.664652873622864 RBM47 1 GO:0021978 telencephalon regionalization 1/770 12/18722 0.395965855962252 0.664652873622864 ADGRG1 1 GO:0030202 heparin metabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 GLCE 1 GO:0030238 male sex determination 1/770 12/18722 0.395965855962252 0.664652873622864 MAP3K4 1 GO:0030259 lipid glycosylation 1/770 12/18722 0.395965855962252 0.664652873622864 ST3GAL4 1 GO:0030397 membrane disassembly 1/770 12/18722 0.395965855962252 0.664652873622864 PAFAH1B1 1 GO:0032096 negative regulation of response to food 1/770 12/18722 0.395965855962252 0.664652873622864 NUCB2 1 GO:0032099 negative regulation of appetite 1/770 12/18722 0.395965855962252 0.664652873622864 NUCB2 1 GO:0032105 negative regulation of response to extracellular stimulus 1/770 12/18722 0.395965855962252 0.664652873622864 NUCB2 1 GO:0032108 negative regulation of response to nutrient levels 1/770 12/18722 0.395965855962252 0.664652873622864 NUCB2 1 GO:0032536 regulation of cell projection size 1/770 12/18722 0.395965855962252 0.664652873622864 EZR 1 GO:0032908 regulation of transforming growth factor beta1 production 1/770 12/18722 0.395965855962252 0.664652873622864 FURIN 1 GO:0032926 negative regulation of activin receptor signaling pathway 1/770 12/18722 0.395965855962252 0.664652873622864 DACT2 1 GO:0033004 negative regulation of mast cell activation 1/770 12/18722 0.395965855962252 0.664652873622864 HMOX1 1 GO:0033015 tetrapyrrole catabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 HMOX1 1 GO:0033629 negative regulation of cell adhesion mediated by integrin 1/770 12/18722 0.395965855962252 0.664652873622864 SERPINE1 1 GO:0034154 toll-like receptor 7 signaling pathway 1/770 12/18722 0.395965855962252 0.664652873622864 DDX3X 1 GO:0035112 genitalia morphogenesis 1/770 12/18722 0.395965855962252 0.664652873622864 CTNNB1 1 GO:0038180 nerve growth factor signaling pathway 1/770 12/18722 0.395965855962252 0.664652873622864 RAPGEF1 1 GO:0042117 monocyte activation 1/770 12/18722 0.395965855962252 0.664652873622864 DYSF 1 GO:0042762 regulation of sulfur metabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 NFE2L2 1 GO:0043129 surfactant homeostasis 1/770 12/18722 0.395965855962252 0.664652873622864 EPAS1 1 GO:0043301 negative regulation of leukocyte degranulation 1/770 12/18722 0.395965855962252 0.664652873622864 HMOX1 1 GO:0043380 regulation of memory T cell differentiation 1/770 12/18722 0.395965855962252 0.664652873622864 CD46 1 GO:0043383 negative T cell selection 1/770 12/18722 0.395965855962252 0.664652873622864 GLI3 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 PPP1CB 1 GO:0043476 pigment accumulation 1/770 12/18722 0.395965855962252 0.664652873622864 CD63 1 GO:0043482 cellular pigment accumulation 1/770 12/18722 0.395965855962252 0.664652873622864 CD63 1 GO:0043696 dedifferentiation 1/770 12/18722 0.395965855962252 0.664652873622864 NCOA3 1 GO:0043697 cell dedifferentiation 1/770 12/18722 0.395965855962252 0.664652873622864 NCOA3 1 GO:0045605 negative regulation of epidermal cell differentiation 1/770 12/18722 0.395965855962252 0.664652873622864 HES1 1 GO:0045683 negative regulation of epidermis development 1/770 12/18722 0.395965855962252 0.664652873622864 HES1 1 GO:0046051 UTP metabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 AK3 1 GO:0046322 negative regulation of fatty acid oxidation 1/770 12/18722 0.395965855962252 0.664652873622864 ACADVL 1 GO:0046541 saliva secretion 1/770 12/18722 0.395965855962252 0.664652873622864 KCNN4 1 GO:0048548 regulation of pinocytosis 1/770 12/18722 0.395965855962252 0.664652873622864 CLN3 1 GO:0048742 regulation of skeletal muscle fiber development 1/770 12/18722 0.395965855962252 0.664652873622864 BCL2 1 GO:0051001 negative regulation of nitric-oxide synthase activity 1/770 12/18722 0.395965855962252 0.664652873622864 GLA 1 GO:0051013 microtubule severing 1/770 12/18722 0.395965855962252 0.664652873622864 VPS4B 1 GO:0051639 actin filament network formation 1/770 12/18722 0.395965855962252 0.664652873622864 SPIRE2 1 GO:0060009 Sertoli cell development 1/770 12/18722 0.395965855962252 0.664652873622864 SDC1 1 GO:0060123 regulation of growth hormone secretion 1/770 12/18722 0.395965855962252 0.664652873622864 SERP1 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/770 12/18722 0.395965855962252 0.664652873622864 LRP1 1 GO:0060453 regulation of gastric acid secretion 1/770 12/18722 0.395965855962252 0.664652873622864 SGK1 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/770 12/18722 0.395965855962252 0.664652873622864 GLI3 1 GO:0060907 positive regulation of macrophage cytokine production 1/770 12/18722 0.395965855962252 0.664652873622864 SEMA7A 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/770 12/18722 0.395965855962252 0.664652873622864 HES1 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/770 12/18722 0.395965855962252 0.664652873622864 HES1 1 GO:0070213 protein auto-ADP-ribosylation 1/770 12/18722 0.395965855962252 0.664652873622864 TNKS2 1 GO:0070493 thrombin-activated receptor signaling pathway 1/770 12/18722 0.395965855962252 0.664652873622864 IQGAP2 1 GO:0070572 positive regulation of neuron projection regeneration 1/770 12/18722 0.395965855962252 0.664652873622864 LRP1 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/770 12/18722 0.395965855962252 0.664652873622864 BRD4 1 GO:0071257 cellular response to electrical stimulus 1/770 12/18722 0.395965855962252 0.664652873622864 SLC9A1 1 GO:0071468 cellular response to acidic pH 1/770 12/18722 0.395965855962252 0.664652873622864 SLC9A1 1 GO:0071472 cellular response to salt stress 1/770 12/18722 0.395965855962252 0.664652873622864 AKR1B1 1 GO:0071635 negative regulation of transforming growth factor beta production 1/770 12/18722 0.395965855962252 0.664652873622864 FURIN 1 GO:0071712 ER-associated misfolded protein catabolic process 1/770 12/18722 0.395965855962252 0.664652873622864 VCP 1 GO:0071872 cellular response to epinephrine stimulus 1/770 12/18722 0.395965855962252 0.664652873622864 SLC9A1 1 GO:0072376 protein activation cascade 1/770 12/18722 0.395965855962252 0.664652873622864 FBLN1 1 GO:0090177 establishment of planar polarity involved in neural tube closure 1/770 12/18722 0.395965855962252 0.664652873622864 DVL3 1 GO:0090331 negative regulation of platelet aggregation 1/770 12/18722 0.395965855962252 0.664652873622864 C1QTNF1 1 GO:0090557 establishment of endothelial intestinal barrier 1/770 12/18722 0.395965855962252 0.664652873622864 RAP2C 1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/770 12/18722 0.395965855962252 0.664652873622864 DNAJB1 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/770 12/18722 0.395965855962252 0.664652873622864 ARF1 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/770 12/18722 0.395965855962252 0.664652873622864 NRP1 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/770 12/18722 0.395965855962252 0.664652873622864 SLC25A5 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/770 12/18722 0.395965855962252 0.664652873622864 EGFR 1 GO:1905214 regulation of RNA binding 1/770 12/18722 0.395965855962252 0.664652873622864 EIF4A3 1 GO:1905666 regulation of protein localization to endosome 1/770 12/18722 0.395965855962252 0.664652873622864 EZR 1 GO:2000035 regulation of stem cell division 1/770 12/18722 0.395965855962252 0.664652873622864 NCOA3 1 GO:2000508 regulation of dendritic cell chemotaxis 1/770 12/18722 0.395965855962252 0.664652873622864 CALR 1 GO:2001214 positive regulation of vasculogenesis 1/770 12/18722 0.395965855962252 0.664652873622864 ADM 1 GO:0003382 epithelial cell morphogenesis 2/770 33/18722 0.396017335297267 0.664652873622864 DACT2/SPINT2 2 GO:0006482 protein demethylation 2/770 33/18722 0.396017335297267 0.664652873622864 UBE2B/KDM5B 2 GO:0008214 protein dealkylation 2/770 33/18722 0.396017335297267 0.664652873622864 UBE2B/KDM5B 2 GO:0010165 response to X-ray 2/770 33/18722 0.396017335297267 0.664652873622864 ANXA1/GATA3 2 GO:0010737 protein kinase A signaling 2/770 33/18722 0.396017335297267 0.664652873622864 EZR/MIF 2 GO:0010984 regulation of lipoprotein particle clearance 2/770 33/18722 0.396017335297267 0.664652873622864 MYLIP/LRPAP1 2 GO:0018345 protein palmitoylation 2/770 33/18722 0.396017335297267 0.664652873622864 ZDHHC3/ZDHHC20 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/770 33/18722 0.396017335297267 0.664652873622864 CLN3/ZDHHC3 2 GO:0033198 response to ATP 2/770 33/18722 0.396017335297267 0.664652873622864 SOD1/HSPD1 2 GO:0034110 regulation of homotypic cell-cell adhesion 2/770 33/18722 0.396017335297267 0.664652873622864 ZNF703/C1QTNF1 2 GO:0040020 regulation of meiotic nuclear division 2/770 33/18722 0.396017335297267 0.664652873622864 UBE2B/CALR 2 GO:0045648 positive regulation of erythrocyte differentiation 2/770 33/18722 0.396017335297267 0.664652873622864 GATA2/HSPA1B 2 GO:0048048 embryonic eye morphogenesis 2/770 33/18722 0.396017335297267 0.664652873622864 TFAP2A/EFEMP1 2 GO:0048730 epidermis morphogenesis 2/770 33/18722 0.396017335297267 0.664652873622864 BCL2/CTNNB1 2 GO:0071539 protein localization to centrosome 2/770 33/18722 0.396017335297267 0.664652873622864 GOLGB1/HOOK3 2 GO:0110110 positive regulation of animal organ morphogenesis 2/770 33/18722 0.396017335297267 0.664652873622864 GATA3/CTNNB1 2 GO:1902692 regulation of neuroblast proliferation 2/770 33/18722 0.396017335297267 0.664652873622864 GLI3/CTNNB1 2 GO:1903715 regulation of aerobic respiration 2/770 33/18722 0.396017335297267 0.664652873622864 NUPR1/VCP 2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/770 33/18722 0.396017335297267 0.664652873622864 EGFR/CCND3 2 GO:0001935 endothelial cell proliferation 9/770 193/18722 0.398477126694391 0.668556068120589 PGF/HMOX1/ERN1/GATA2/PDPK1/RICTOR/NRP1/PDCD6/MYDGF 9 GO:0007259 receptor signaling pathway via JAK-STAT 8/770 170/18722 0.399977292692373 0.669342066616885 AKR1B1/HES1/GHR/SOCS1/LEPROT/IL10RB/PRLR/OSBP 8 GO:0030178 negative regulation of Wnt signaling pathway 8/770 170/18722 0.399977292692373 0.669342066616885 DAB2/SIAH2/DDIT3/GLI3/LATS2/CSNK1A1/LRP1/GPC3 8 GO:0008306 associative learning 4/770 78/18722 0.400288853806606 0.669342066616885 APP/CLN3/CLN8/EIF4A3 4 GO:0019319 hexose biosynthetic process 4/770 78/18722 0.400288853806606 0.669342066616885 ATF3/AKR1B1/DDB1/SLC35B4 4 GO:0032371 regulation of sterol transport 4/770 78/18722 0.400288853806606 0.669342066616885 NFKBIA/FURIN/ABCG1/LRP1 4 GO:0032374 regulation of cholesterol transport 4/770 78/18722 0.400288853806606 0.669342066616885 NFKBIA/FURIN/ABCG1/LRP1 4 GO:0035050 embryonic heart tube development 4/770 78/18722 0.400288853806606 0.669342066616885 TBX3/HES1/MIB1/CTNNB1 4 GO:0043297 apical junction assembly 4/770 78/18722 0.400288853806606 0.669342066616885 CLDN7/DLG5/MPP7/CLDN4 4 GO:0061045 negative regulation of wound healing 4/770 78/18722 0.400288853806606 0.669342066616885 SERPINB2/SERPINE1/PHLDB2/C1QTNF1 4 GO:0090559 regulation of membrane permeability 4/770 78/18722 0.400288853806606 0.669342066616885 PMAIP1/BCL2/SLC25A5/SLC9A1 4 GO:0098869 cellular oxidant detoxification 5/770 101/18722 0.401877122317955 0.671772459077616 GPX3/MGST3/PRDX6/SOD1/NFE2L2 5 GO:0050777 negative regulation of immune response 9/770 194/18722 0.404369446001265 0.675569834427925 ANXA1/HMOX1/CD55/ARG2/FURIN/SERPINB9/CD46/PSMB4/CD59 9 GO:0044843 cell cycle G1/S phase transition 11/770 241/18722 0.405574167857314 0.675569834427925 ANXA1/EGFR/BCL2/ID2/LATS2/MDM2/CDK2/DDX3X/GIGYF2/BRD4/CCND3 11 GO:1903311 regulation of mRNA metabolic process 13/770 288/18722 0.405727543634994 0.675569834427925 PAPOLA/MBNL3/SAP18/DHX36/LARP4B/RBM8A/RBM42/GIGYF2/SUPT6H/IWS1/AGO2/PRDX6/HSPA8 13 GO:0006687 glycosphingolipid metabolic process 3/770 56/18722 0.406578861043012 0.675569834427925 NEU1/GLTP/GLA 3 GO:0032608 interferon-beta production 3/770 56/18722 0.406578861043012 0.675569834427925 DDX3X/TBK1/HSP90AA1 3 GO:0032648 regulation of interferon-beta production 3/770 56/18722 0.406578861043012 0.675569834427925 DDX3X/TBK1/HSP90AA1 3 GO:0042733 embryonic digit morphogenesis 3/770 56/18722 0.406578861043012 0.675569834427925 TBX3/GLI3/CTNNB1 3 GO:0043470 regulation of carbohydrate catabolic process 3/770 56/18722 0.406578861043012 0.675569834427925 NUPR1/APP/PPP1CB 3 GO:0046622 positive regulation of organ growth 3/770 56/18722 0.406578861043012 0.675569834427925 BASP1/SERP1/TGFBR3 3 GO:0051058 negative regulation of small GTPase mediated signal transduction 3/770 56/18722 0.406578861043012 0.675569834427925 RASA1/ARHGAP24/KANK1 3 GO:0055078 sodium ion homeostasis 3/770 56/18722 0.406578861043012 0.675569834427925 NEDD4L/MLLT6/SLC9A1 3 GO:0090175 regulation of establishment of planar polarity 3/770 56/18722 0.406578861043012 0.675569834427925 DAB2/DVL3/GPC3 3 GO:1904645 response to amyloid-beta 3/770 56/18722 0.406578861043012 0.675569834427925 APP/LRP1/SNX6 3 GO:0050803 regulation of synapse structure or activity 10/770 218/18722 0.407926387782999 0.675569834427925 APP/VCP/DHX36/ARF4/CLN3/DLG5/CHMP2B/PAFAH1B1/CDKL5/HSPA8 10 GO:0044272 sulfur compound biosynthetic process 7/770 148/18722 0.407963577720975 0.675569834427925 SLC26A2/ST3GAL4/ACSS1/GLCE/CHPF/CDO1/NFE2L2 7 GO:0050905 neuromuscular process 7/770 148/18722 0.407963577720975 0.675569834427925 APP/TMEM150C/CLN3/CLN8/GIGYF2/PAFAH1B1/UBA5 7 GO:0097530 granulocyte migration 7/770 148/18722 0.407963577720975 0.675569834427925 ANXA1/CSF3R/VAV3/MPP1/AKIRIN1/BSG/PPIB 7 GO:0030522 intracellular receptor signaling pathway 12/770 265/18722 0.408271635046921 0.675569834427925 DAB2/ESRRG/NFKBIA/UBR5/PPARD/NR2F6/EGLN2/HSPA1B/CALR/DNAJA1/UBA5/ACTN4 12 GO:0006023 aminoglycan biosynthetic process 4/770 79/18722 0.409638636993459 0.675569834427925 ST3GAL4/AP2A1/GLCE/CHPF 4 GO:0000096 sulfur amino acid metabolic process 2/770 34/18722 0.41059140108543 0.675569834427925 SMS/CDO1 2 GO:0007095 mitotic G2 DNA damage checkpoint signaling 2/770 34/18722 0.41059140108543 0.675569834427925 FOXO4/TAOK1 2 GO:0007431 salivary gland development 2/770 34/18722 0.41059140108543 0.675569834427925 TGM2/NRP1 2 GO:0010614 negative regulation of cardiac muscle hypertrophy 2/770 34/18722 0.41059140108543 0.675569834427925 LMNA/ERRFI1 2 GO:0030851 granulocyte differentiation 2/770 34/18722 0.41059140108543 0.675569834427925 GATA2/CEBPA 2 GO:0032743 positive regulation of interleukin-2 production 2/770 34/18722 0.41059140108543 0.675569834427925 ANXA1/PNP 2 GO:0035590 purinergic nucleotide receptor signaling pathway 2/770 34/18722 0.41059140108543 0.675569834427925 GPR87/P2RY6 2 GO:0035909 aorta morphogenesis 2/770 34/18722 0.41059140108543 0.675569834427925 HES1/LRP1 2 GO:0048536 spleen development 2/770 34/18722 0.41059140108543 0.675569834427925 BCL2/PBX1 2 GO:0050869 negative regulation of B cell activation 2/770 34/18722 0.41059140108543 0.675569834427925 ID2/TNFRSF21 2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 2/770 34/18722 0.41059140108543 0.675569834427925 TGM2/GPR157 2 GO:1904893 negative regulation of receptor signaling pathway via STAT 2/770 34/18722 0.41059140108543 0.675569834427925 SOCS1/LEPROT 2 GO:2000780 negative regulation of double-strand break repair 2/770 34/18722 0.41059140108543 0.675569834427925 OTUB2/UBR5 2 GO:1901136 carbohydrate derivative catabolic process 8/770 172/18722 0.412549984560868 0.675569834427925 CTSL/PNP/BPGM/NEU1/EDEM1/FUCA1/IDS/GLA 8 GO:0046394 carboxylic acid biosynthetic process 14/770 314/18722 0.417185769094288 0.675569834427925 ANXA1/KMO/SERINC5/ABHD3/ACSS1/CLN3/PNPLA8/MGST3/ACADVL/OSBP/RDH10/ASNSD1/MIF/INSIG1 14 GO:0002011 morphogenesis of an epithelial sheet 3/770 57/18722 0.417689043063565 0.675569834427925 ARHGAP24/PHLDB2/FERMT2 3 GO:0016447 somatic recombination of immunoglobulin gene segments 3/770 57/18722 0.417689043063565 0.675569834427925 TFRC/SUPT6H/HSPD1 3 GO:0030219 megakaryocyte differentiation 3/770 57/18722 0.417689043063565 0.675569834427925 SCIN/GATA2/UBA5 3 GO:0033619 membrane protein proteolysis 3/770 57/18722 0.417689043063565 0.675569834427925 BACE2/FURIN/SNX9 3 GO:0060760 positive regulation of response to cytokine stimulus 3/770 57/18722 0.417689043063565 0.675569834427925 HSPA1B/TBK1/PAFAH1B1 3 GO:0009135 purine nucleoside diphosphate metabolic process 5/770 103/18722 0.418255169419154 0.675569834427925 NUPR1/APP/AK3/MPP1/BPGM 5 GO:0009179 purine ribonucleoside diphosphate metabolic process 5/770 103/18722 0.418255169419154 0.675569834427925 NUPR1/APP/AK3/MPP1/BPGM 5 GO:0030148 sphingolipid biosynthetic process 5/770 103/18722 0.418255169419154 0.675569834427925 SPTSSA/PLPP3/SAMD8/CLN8/ORMDL1 5 GO:0030593 neutrophil chemotaxis 5/770 103/18722 0.418255169419154 0.675569834427925 CSF3R/VAV3/MPP1/BSG/PPIB 5 GO:0032760 positive regulation of tumor necrosis factor production 5/770 103/18722 0.418255169419154 0.675569834427925 HSPB1/APP/DDT/MIF/HSPD1 5 GO:0051099 positive regulation of binding 8/770 173/18722 0.418833377515108 0.675569834427925 GATA3/APP/HES1/EDF1/GTF2B/CTNNB1/LRP1/NRP1 8 GO:0001570 vasculogenesis 4/770 80/18722 0.418958164181933 0.675569834427925 RASA1/CTNNB1/TGFBR3/ADM 4 GO:0051251 positive regulation of lymphocyte activation 16/770 362/18722 0.420059271587008 0.675569834427925 ANXA1/PRKCZ/TFRC/GATA3/CD55/VAV3/PNP/HES1/BCL2/GLI3/SOCS1/CD274/CD46/IRS2/MIF/HSPD1 16 GO:0001833 inner cell mass cell proliferation 1/770 13/18722 0.420824556705655 0.675569834427925 SBDS 1 GO:0002551 mast cell chemotaxis 1/770 13/18722 0.420824556705655 0.675569834427925 PGF 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/770 13/18722 0.420824556705655 0.675569834427925 CTNNB1 1 GO:0006000 fructose metabolic process 1/770 13/18722 0.420824556705655 0.675569834427925 AKR1B1 1 GO:0006586 indolalkylamine metabolic process 1/770 13/18722 0.420824556705655 0.675569834427925 KMO 1 GO:0007494 midgut development 1/770 13/18722 0.420824556705655 0.675569834427925 EGFR 1 GO:0007567 parturition 1/770 13/18722 0.420824556705655 0.675569834427925 MAFF 1 GO:0008298 intracellular mRNA localization 1/770 13/18722 0.420824556705655 0.675569834427925 DHX36 1 GO:0010635 regulation of mitochondrial fusion 1/770 13/18722 0.420824556705655 0.675569834427925 TFRC 1 GO:0010755 regulation of plasminogen activation 1/770 13/18722 0.420824556705655 0.675569834427925 SERPINE1 1 GO:0010958 regulation of amino acid import across plasma membrane 1/770 13/18722 0.420824556705655 0.675569834427925 SLC43A2 1 GO:0014029 neural crest formation 1/770 13/18722 0.420824556705655 0.675569834427925 PDCD6 1 GO:0016246 RNA interference 1/770 13/18722 0.420824556705655 0.675569834427925 AGO2 1 GO:0016322 neuron remodeling 1/770 13/18722 0.420824556705655 0.675569834427925 APP 1 GO:0019336 phenol-containing compound catabolic process 1/770 13/18722 0.420824556705655 0.675569834427925 MAOA 1 GO:0021554 optic nerve development 1/770 13/18722 0.420824556705655 0.675569834427925 GLI3 1 GO:0021681 cerebellar granular layer development 1/770 13/18722 0.420824556705655 0.675569834427925 OPHN1 1 GO:0021984 adenohypophysis development 1/770 13/18722 0.420824556705655 0.675569834427925 HES1 1 GO:0031053 primary miRNA processing 1/770 13/18722 0.420824556705655 0.675569834427925 DDX3X 1 GO:0031272 regulation of pseudopodium assembly 1/770 13/18722 0.420824556705655 0.675569834427925 CDC42EP4 1 GO:0031274 positive regulation of pseudopodium assembly 1/770 13/18722 0.420824556705655 0.675569834427925 CDC42EP4 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/770 13/18722 0.420824556705655 0.675569834427925 ANXA1 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/770 13/18722 0.420824556705655 0.675569834427925 ZDHHC3 1 GO:0032530 regulation of microvillus organization 1/770 13/18722 0.420824556705655 0.675569834427925 EZR 1 GO:0032905 transforming growth factor beta1 production 1/770 13/18722 0.420824556705655 0.675569834427925 FURIN 1 GO:0033689 negative regulation of osteoblast proliferation 1/770 13/18722 0.420824556705655 0.675569834427925 BCL2 1 GO:0033700 phospholipid efflux 1/770 13/18722 0.420824556705655 0.675569834427925 ABCG1 1 GO:0034497 protein localization to phagophore assembly site 1/770 13/18722 0.420824556705655 0.675569834427925 ATG9B 1 GO:0035331 negative regulation of hippo signaling 1/770 13/18722 0.420824556705655 0.675569834427925 DLG5 1 GO:0036302 atrioventricular canal development 1/770 13/18722 0.420824556705655 0.675569834427925 TBX3 1 GO:0042538 hyperosmotic salinity response 1/770 13/18722 0.420824556705655 0.675569834427925 AKR1B1 1 GO:0042769 DNA damage response, detection of DNA damage 1/770 13/18722 0.420824556705655 0.675569834427925 DNAJA1 1 GO:0043201 response to leucine 1/770 13/18722 0.420824556705655 0.675569834427925 UBR1 1 GO:0043379 memory T cell differentiation 1/770 13/18722 0.420824556705655 0.675569834427925 CD46 1 GO:0043970 histone H3-K9 acetylation 1/770 13/18722 0.420824556705655 0.675569834427925 GATA3 1 GO:0046689 response to mercury ion 1/770 13/18722 0.420824556705655 0.675569834427925 BSG 1 GO:0048012 hepatocyte growth factor receptor signaling pathway 1/770 13/18722 0.420824556705655 0.675569834427925 NRP1 1 GO:0048070 regulation of developmental pigmentation 1/770 13/18722 0.420824556705655 0.675569834427925 BCL2 1 GO:0048266 behavioral response to pain 1/770 13/18722 0.420824556705655 0.675569834427925 VWA1 1 GO:0048820 hair follicle maturation 1/770 13/18722 0.420824556705655 0.675569834427925 CTNNB1 1 GO:0051481 negative regulation of cytosolic calcium ion concentration 1/770 13/18722 0.420824556705655 0.675569834427925 LRP1 1 GO:0051709 regulation of killing of cells of other organism 1/770 13/18722 0.420824556705655 0.675569834427925 SERPINB9 1 GO:0051956 negative regulation of amino acid transport 1/770 13/18722 0.420824556705655 0.675569834427925 SLC43A2 1 GO:0060100 positive regulation of phagocytosis, engulfment 1/770 13/18722 0.420824556705655 0.675569834427925 GATA2 1 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/770 13/18722 0.420824556705655 0.675569834427925 AGO2 1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/770 13/18722 0.420824556705655 0.675569834427925 TBK1 1 GO:0060347 heart trabecula formation 1/770 13/18722 0.420824556705655 0.675569834427925 TGFBR3 1 GO:0060707 trophoblast giant cell differentiation 1/770 13/18722 0.420824556705655 0.675569834427925 HECTD1 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/770 13/18722 0.420824556705655 0.675569834427925 NFE2L2 1 GO:0070254 mucus secretion 1/770 13/18722 0.420824556705655 0.675569834427925 EGFR 1 GO:0070316 regulation of G0 to G1 transition 1/770 13/18722 0.420824556705655 0.675569834427925 FOXO4 1 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 1/770 13/18722 0.420824556705655 0.675569834427925 HSPA1B 1 GO:0070914 UV-damage excision repair 1/770 13/18722 0.420824556705655 0.675569834427925 DDB1 1 GO:0071027 nuclear RNA surveillance 1/770 13/18722 0.420824556705655 0.675569834427925 XRN1 1 GO:0071028 nuclear mRNA surveillance 1/770 13/18722 0.420824556705655 0.675569834427925 XRN1 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/770 13/18722 0.420824556705655 0.675569834427925 HOOK3 1 GO:0090042 tubulin deacetylation 1/770 13/18722 0.420824556705655 0.675569834427925 BEX4 1 GO:0097154 GABAergic neuron differentiation 1/770 13/18722 0.420824556705655 0.675569834427925 GATA2 1 GO:0098814 spontaneous synaptic transmission 1/770 13/18722 0.420824556705655 0.675569834427925 APP 1 GO:0098840 protein transport along microtubule 1/770 13/18722 0.420824556705655 0.675569834427925 HSPB1 1 GO:0099118 microtubule-based protein transport 1/770 13/18722 0.420824556705655 0.675569834427925 HSPB1 1 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/770 13/18722 0.420824556705655 0.675569834427925 ARRDC3 1 GO:0110096 cellular response to aldehyde 1/770 13/18722 0.420824556705655 0.675569834427925 AKR1B1 1 GO:0120305 regulation of pigmentation 1/770 13/18722 0.420824556705655 0.675569834427925 BCL2 1 GO:1900272 negative regulation of long-term synaptic potentiation 1/770 13/18722 0.420824556705655 0.675569834427925 APP 1 GO:1901387 positive regulation of voltage-gated calcium channel activity 1/770 13/18722 0.420824556705655 0.675569834427925 EHD3 1 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 1/770 13/18722 0.420824556705655 0.675569834427925 NRP1 1 GO:1902947 regulation of tau-protein kinase activity 1/770 13/18722 0.420824556705655 0.675569834427925 HSP90AA1 1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1/770 13/18722 0.420824556705655 0.675569834427925 DDIT3 1 GO:1903789 regulation of amino acid transmembrane transport 1/770 13/18722 0.420824556705655 0.675569834427925 SLC43A2 1 GO:1903977 positive regulation of glial cell migration 1/770 13/18722 0.420824556705655 0.675569834427925 LRP1 1 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 1/770 13/18722 0.420824556705655 0.675569834427925 PDCD4 1 GO:1905155 positive regulation of membrane invagination 1/770 13/18722 0.420824556705655 0.675569834427925 GATA2 1 GO:1905907 negative regulation of amyloid fibril formation 1/770 13/18722 0.420824556705655 0.675569834427925 LDLR 1 GO:1905939 regulation of gonad development 1/770 13/18722 0.420824556705655 0.675569834427925 NUPR1 1 GO:2001198 regulation of dendritic cell differentiation 1/770 13/18722 0.420824556705655 0.675569834427925 CEBPB 1 GO:0051224 negative regulation of protein transport 6/770 127/18722 0.424064560283917 0.67875810164377 ANXA1/PIM3/CD200/ERLEC1/INSIG1/RAB11FIP1 6 GO:0000731 DNA synthesis involved in DNA repair 2/770 35/18722 0.424990021498808 0.67875810164377 VCP/USP43 2 GO:0001569 branching involved in blood vessel morphogenesis 2/770 35/18722 0.424990021498808 0.67875810164377 CTNNB1/NRP1 2 GO:0001893 maternal placenta development 2/770 35/18722 0.424990021498808 0.67875810164377 PPARD/BSG 2 GO:0006471 protein ADP-ribosylation 2/770 35/18722 0.424990021498808 0.67875810164377 ARF4/TNKS2 2 GO:0021955 central nervous system neuron axonogenesis 2/770 35/18722 0.424990021498808 0.67875810164377 HSP90AA1/PAFAH1B1 2 GO:0032205 negative regulation of telomere maintenance 2/770 35/18722 0.424990021498808 0.67875810164377 TNKS2/XRN1 2 GO:0032232 negative regulation of actin filament bundle assembly 2/770 35/18722 0.424990021498808 0.67875810164377 PHLDB2/PPFIA1 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/770 35/18722 0.424990021498808 0.67875810164377 RYBP/UBXN1 2 GO:0034405 response to fluid shear stress 2/770 35/18722 0.424990021498808 0.67875810164377 MTSS1/NFE2L2 2 GO:0039694 viral RNA genome replication 2/770 35/18722 0.424990021498808 0.67875810164377 EEA1/RAB5A 2 GO:0040001 establishment of mitotic spindle localization 2/770 35/18722 0.424990021498808 0.67875810164377 NUMA1/PAFAH1B1 2 GO:0045880 positive regulation of smoothened signaling pathway 2/770 35/18722 0.424990021498808 0.67875810164377 DLG5/GPC3 2 GO:0045922 negative regulation of fatty acid metabolic process 2/770 35/18722 0.424990021498808 0.67875810164377 ACADVL/INSIG1 2 GO:0048821 erythrocyte development 2/770 35/18722 0.424990021498808 0.67875810164377 ALAS1/BPGM 2 GO:1905207 regulation of cardiocyte differentiation 2/770 35/18722 0.424990021498808 0.67875810164377 EGFR/DHX36 2 GO:0032963 collagen metabolic process 5/770 104/18722 0.426417050444195 0.680512407337005 CTSL/FURIN/PPARD/SUCO/ERRFI1 5 GO:1901890 positive regulation of cell junction assembly 5/770 104/18722 0.426417050444195 0.680512407337005 FMN1/DLG5/CRB3/NRP1/FERMT2 5 GO:0043414 macromolecule methylation 14/770 316/18722 0.426498143309947 0.680512407337005 GATA3/ETF1/MBD3/BTG1/KMT2C/TET2/MLLT6/LMNA/CTNNB1/PCMTD1/SUPT6H/IWS1/BRD4/RNMT 14 GO:0017148 negative regulation of translation 11/770 245/18722 0.426727874528871 0.680661011132319 EIF2AK1/CPEB4/PAIP2/DHX36/GRB7/XRN1/DDX3X/GIGYF2/CALR/EIF4A3/AGO2 11 GO:0008589 regulation of smoothened signaling pathway 4/770 81/18722 0.428242930630055 0.681672618697632 GLI3/VCP/DLG5/GPC3 4 GO:0021954 central nervous system neuron development 4/770 81/18722 0.428242930630055 0.681672618697632 GATA2/NRP1/HSP90AA1/PAFAH1B1 4 GO:0046209 nitric oxide metabolic process 4/770 81/18722 0.428242930630055 0.681672618697632 ARG2/GLA/DYNLL1/HSP90AA1 4 GO:0060968 regulation of gene silencing 4/770 81/18722 0.428242930630055 0.681672618697632 EGFR/NEAT1/CDK2/AGO2 4 GO:0071260 cellular response to mechanical stimulus 4/770 81/18722 0.428242930630055 0.681672618697632 SLC2A1/EGFR/TMEM150C/SLC9A1 4 GO:2000243 positive regulation of reproductive process 4/770 81/18722 0.428242930630055 0.681672618697632 UBE2B/OVOL1/CTNNB1/AGO2 4 GO:0006826 iron ion transport 3/770 58/18722 0.428730079670555 0.681672618697632 SLC40A1/TFRC/PGRMC2 3 GO:0009161 ribonucleoside monophosphate metabolic process 3/770 58/18722 0.428730079670555 0.681672618697632 AK3/PNP/MPP1 3 GO:0044380 protein localization to cytoskeleton 3/770 58/18722 0.428730079670555 0.681672618697632 GOLGB1/HOOK3/NUMA1 3 GO:2000736 regulation of stem cell differentiation 3/770 58/18722 0.428730079670555 0.681672618697632 HES1/DHX36/NFE2L2 3 GO:0000041 transition metal ion transport 5/770 105/18722 0.434556626360924 0.682188478978583 SLC40A1/TFRC/PGRMC2/SLC39A7/COX17 5 GO:0016573 histone acetylation 7/770 152/18722 0.434989052395518 0.682188478978583 GATA3/NCOA3/MBD3/GATA2/GTF2B/IWS1/RPS6KA5 7 GO:0051092 positive regulation of NF-kappaB transcription factor activity 7/770 152/18722 0.434989052395518 0.682188478978583 PRKCZ/TFRC/APP/ERC1/HSPA1B/RPS6KA5/MAP3K13 7 GO:0043242 negative regulation of protein-containing complex disassembly 4/770 82/18722 0.437488597557433 0.682188478978583 SCIN/ATXN7/CAMSAP2/TAOK1 4 GO:0046364 monosaccharide biosynthetic process 4/770 82/18722 0.437488597557433 0.682188478978583 ATF3/AKR1B1/DDB1/SLC35B4 4 GO:0060395 SMAD protein signal transduction 4/770 82/18722 0.437488597557433 0.682188478978583 GDF15/DAB2/LRP1/SUB1 4 GO:0072527 pyrimidine-containing compound metabolic process 4/770 82/18722 0.437488597557433 0.682188478978583 SLC19A2/AK3/SLC19A3/TET2 4 GO:2001057 reactive nitrogen species metabolic process 4/770 82/18722 0.437488597557433 0.682188478978583 ARG2/GLA/DYNLL1/HSP90AA1 4 GO:0050728 negative regulation of inflammatory response 8/770 176/18722 0.437653169380186 0.682188478978583 GATA3/CD200/FURIN/PPARD/LDLR/PSMB4/SERPINF1/SOD1 8 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/770 129/18722 0.438752293074031 0.682188478978583 PMAIP1/VCP/DDX3X/PDCD6/HSPE1/HSPD1 6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2/770 36/18722 0.439202970374178 0.682188478978583 CTSL/ARL8B 2 GO:0003203 endocardial cushion morphogenesis 2/770 36/18722 0.439202970374178 0.682188478978583 TBX3/MDM2 2 GO:0010092 specification of animal organ identity 2/770 36/18722 0.439202970374178 0.682188478978583 GLI3/CTNNB1 2 GO:0010762 regulation of fibroblast migration 2/770 36/18722 0.439202970374178 0.682188478978583 GNA12/CLN3 2 GO:0014741 negative regulation of muscle hypertrophy 2/770 36/18722 0.439202970374178 0.682188478978583 LMNA/ERRFI1 2 GO:0017004 cytochrome complex assembly 2/770 36/18722 0.439202970374178 0.682188478978583 COX17/COX20 2 GO:0036314 response to sterol 2/770 36/18722 0.439202970374178 0.682188478978583 GRAMD1C/INSIG1 2 GO:0038179 neurotrophin signaling pathway 2/770 36/18722 0.439202970374178 0.682188478978583 RAPGEF1/AKT1S1 2 GO:0043949 regulation of cAMP-mediated signaling 2/770 36/18722 0.439202970374178 0.682188478978583 UBE2B/GNAI1 2 GO:0045191 regulation of isotype switching 2/770 36/18722 0.439202970374178 0.682188478978583 TFRC/SUPT6H 2 GO:0045652 regulation of megakaryocyte differentiation 2/770 36/18722 0.439202970374178 0.682188478978583 SCIN/GATA2 2 GO:0045738 negative regulation of DNA repair 2/770 36/18722 0.439202970374178 0.682188478978583 OTUB2/UBR5 2 GO:0045746 negative regulation of Notch signaling pathway 2/770 36/18722 0.439202970374178 0.682188478978583 NFKBIA/GATA2 2 GO:0051955 regulation of amino acid transport 2/770 36/18722 0.439202970374178 0.682188478978583 KMO/SLC43A2 2 GO:0060251 regulation of glial cell proliferation 2/770 36/18722 0.439202970374178 0.682188478978583 EGFR/HES1 2 GO:0070306 lens fiber cell differentiation 2/770 36/18722 0.439202970374178 0.682188478978583 TBC1D20/KDM5B 2 GO:0070897 transcription preinitiation complex assembly 2/770 36/18722 0.439202970374178 0.682188478978583 GTF2B/PSMC6 2 GO:0071402 cellular response to lipoprotein particle stimulus 2/770 36/18722 0.439202970374178 0.682188478978583 ABCG1/LDLR 2 GO:0090313 regulation of protein targeting to membrane 2/770 36/18722 0.439202970374178 0.682188478978583 TCAF1/STOM 2 GO:0006406 mRNA export from nucleus 3/770 59/18722 0.439695501132238 0.682188478978583 SUPT6H/IWS1/ALYREF 3 GO:0033013 tetrapyrrole metabolic process 3/770 59/18722 0.439695501132238 0.682188478978583 HMOX1/ALAS1/EIF2AK1 3 GO:0048278 vesicle docking 3/770 59/18722 0.439695501132238 0.682188478978583 CLN3/STX5/STXBP3 3 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 3/770 59/18722 0.439695501132238 0.682188478978583 SUPT6H/IWS1/ALYREF 3 GO:0009185 ribonucleoside diphosphate metabolic process 5/770 106/18722 0.442670848310133 0.682188478978583 NUPR1/APP/AK3/MPP1/BPGM 5 GO:0019882 antigen processing and presentation 5/770 106/18722 0.442670848310133 0.682188478978583 CTSL/ARL8B/RAB5B/SAR1B/CALR 5 GO:0071466 cellular response to xenobiotic stimulus 8/770 177/18722 0.443911269969716 0.682188478978583 GSTA3/TFRC/EGFR/CYP2J2/GSTA4/RAP1B/HSPA5/NFE2L2 8 GO:0000212 meiotic spindle organization 1/770 14/18722 0.444661484993465 0.682188478978583 GOLGA2 1 GO:0001711 endodermal cell fate commitment 1/770 14/18722 0.444661484993465 0.682188478978583 CTNNB1 1 GO:0001767 establishment of lymphocyte polarity 1/770 14/18722 0.444661484993465 0.682188478978583 SNX27 1 GO:0002091 negative regulation of receptor internalization 1/770 14/18722 0.444661484993465 0.682188478978583 LRPAP1 1 GO:0002517 T cell tolerance induction 1/770 14/18722 0.444661484993465 0.682188478978583 PHLPP1 1 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/770 14/18722 0.444661484993465 0.682188478978583 EZR 1 GO:0006521 regulation of cellular amino acid metabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 CLN3 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/770 14/18722 0.444661484993465 0.682188478978583 PRLR 1 GO:0009071 serine family amino acid catabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 CDO1 1 GO:0009158 ribonucleoside monophosphate catabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 PNP 1 GO:0009159 deoxyribonucleoside monophosphate catabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 PNP 1 GO:0010457 centriole-centriole cohesion 1/770 14/18722 0.444661484993465 0.682188478978583 CTNNB1 1 GO:0010867 positive regulation of triglyceride biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 LDLR 1 GO:0010872 regulation of cholesterol esterification 1/770 14/18722 0.444661484993465 0.682188478978583 ABCG1 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/770 14/18722 0.444661484993465 0.682188478978583 MYLIP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/770 14/18722 0.444661484993465 0.682188478978583 FBXO32 1 GO:0015074 DNA integration 1/770 14/18722 0.444661484993465 0.682188478978583 ZNF91 1 GO:0022038 corpus callosum development 1/770 14/18722 0.444661484993465 0.682188478978583 PAFAH1B1 1 GO:0030213 hyaluronan biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 AP2A1 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/770 14/18722 0.444661484993465 0.682188478978583 PDCD6 1 GO:0031054 pre-miRNA processing 1/770 14/18722 0.444661484993465 0.682188478978583 AGO2 1 GO:0031650 regulation of heat generation 1/770 14/18722 0.444661484993465 0.682188478978583 ARRDC3 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/770 14/18722 0.444661484993465 0.682188478978583 GATA2 1 GO:0034616 response to laminar fluid shear stress 1/770 14/18722 0.444661484993465 0.682188478978583 NFE2L2 1 GO:0035630 bone mineralization involved in bone maturation 1/770 14/18722 0.444661484993465 0.682188478978583 PHOSPHO1 1 GO:0035672 oligopeptide transmembrane transport 1/770 14/18722 0.444661484993465 0.682188478978583 SLC13A3 1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1/770 14/18722 0.444661484993465 0.682188478978583 LRP1 1 GO:0042921 glucocorticoid receptor signaling pathway 1/770 14/18722 0.444661484993465 0.682188478978583 CALR 1 GO:0043306 positive regulation of mast cell degranulation 1/770 14/18722 0.444661484993465 0.682188478978583 GATA2 1 GO:0043455 regulation of secondary metabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 OPN3 1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1/770 14/18722 0.444661484993465 0.682188478978583 PMAIP1 1 GO:0043558 regulation of translational initiation in response to stress 1/770 14/18722 0.444661484993465 0.682188478978583 EIF2AK1 1 GO:0043650 dicarboxylic acid biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 KMO 1 GO:0043922 negative regulation by host of viral transcription 1/770 14/18722 0.444661484993465 0.682188478978583 PSMC3 1 GO:0043951 negative regulation of cAMP-mediated signaling 1/770 14/18722 0.444661484993465 0.682188478978583 UBE2B 1 GO:0044154 histone H3-K14 acetylation 1/770 14/18722 0.444661484993465 0.682188478978583 GATA3 1 GO:0044764 multi-organism cellular process 1/770 14/18722 0.444661484993465 0.682188478978583 CTSL 1 GO:0045023 G0 to G1 transition 1/770 14/18722 0.444661484993465 0.682188478978583 FOXO4 1 GO:0045472 response to ether 1/770 14/18722 0.444661484993465 0.682188478978583 MDM2 1 GO:0045820 negative regulation of glycolytic process 1/770 14/18722 0.444661484993465 0.682188478978583 NUPR1 1 GO:0046325 negative regulation of glucose import 1/770 14/18722 0.444661484993465 0.682188478978583 STXBP3 1 GO:0047484 regulation of response to osmotic stress 1/770 14/18722 0.444661484993465 0.682188478978583 CLN3 1 GO:0048021 regulation of melanin biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 OPN3 1 GO:0048291 isotype switching to IgG isotypes 1/770 14/18722 0.444661484993465 0.682188478978583 HSPD1 1 GO:0048875 chemical homeostasis within a tissue 1/770 14/18722 0.444661484993465 0.682188478978583 EPAS1 1 GO:0050872 white fat cell differentiation 1/770 14/18722 0.444661484993465 0.682188478978583 CEBPA 1 GO:0050930 induction of positive chemotaxis 1/770 14/18722 0.444661484993465 0.682188478978583 PGF 1 GO:0051589 negative regulation of neurotransmitter transport 1/770 14/18722 0.444661484993465 0.682188478978583 RAP1B 1 GO:0051764 actin crosslink formation 1/770 14/18722 0.444661484993465 0.682188478978583 GAS2L3 1 GO:0051917 regulation of fibrinolysis 1/770 14/18722 0.444661484993465 0.682188478978583 SERPINE1 1 GO:0051984 positive regulation of chromosome segregation 1/770 14/18722 0.444661484993465 0.682188478978583 NUMA1 1 GO:0055057 neuroblast division 1/770 14/18722 0.444661484993465 0.682188478978583 TEAD3 1 GO:0060081 membrane hyperpolarization 1/770 14/18722 0.444661484993465 0.682188478978583 PRKCZ 1 GO:0060088 auditory receptor cell stereocilium organization 1/770 14/18722 0.444661484993465 0.682188478978583 SOD1 1 GO:0060576 intestinal epithelial cell development 1/770 14/18722 0.444661484993465 0.682188478978583 YIPF6 1 GO:0060732 positive regulation of inositol phosphate biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 P2RY6 1 GO:0060911 cardiac cell fate commitment 1/770 14/18722 0.444661484993465 0.682188478978583 TBX3 1 GO:0061043 regulation of vascular wound healing 1/770 14/18722 0.444661484993465 0.682188478978583 SERPINE1 1 GO:0070307 lens fiber cell development 1/770 14/18722 0.444661484993465 0.682188478978583 TBC1D20 1 GO:0071415 cellular response to purine-containing compound 1/770 14/18722 0.444661484993465 0.682188478978583 P2RY6 1 GO:0071481 cellular response to X-ray 1/770 14/18722 0.444661484993465 0.682188478978583 GATA3 1 GO:0072350 tricarboxylic acid metabolic process 1/770 14/18722 0.444661484993465 0.682188478978583 ACO2 1 GO:0072498 embryonic skeletal joint development 1/770 14/18722 0.444661484993465 0.682188478978583 CTNNB1 1 GO:0090239 regulation of histone H4 acetylation 1/770 14/18722 0.444661484993465 0.682188478978583 IWS1 1 GO:0090715 immunological memory formation process 1/770 14/18722 0.444661484993465 0.682188478978583 CD46 1 GO:0097091 synaptic vesicle clustering 1/770 14/18722 0.444661484993465 0.682188478978583 CTNNB1 1 GO:0097531 mast cell migration 1/770 14/18722 0.444661484993465 0.682188478978583 PGF 1 GO:0098787 mRNA cleavage involved in mRNA processing 1/770 14/18722 0.444661484993465 0.682188478978583 ERN1 1 GO:0099188 postsynaptic cytoskeleton organization 1/770 14/18722 0.444661484993465 0.682188478978583 ARF1 1 GO:1900376 regulation of secondary metabolite biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 OPN3 1 GO:1901678 iron coordination entity transport 1/770 14/18722 0.444661484993465 0.682188478978583 PGRMC2 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/770 14/18722 0.444661484993465 0.682188478978583 GATA3 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/770 14/18722 0.444661484993465 0.682188478978583 NFE2L2 1 GO:1902916 positive regulation of protein polyubiquitination 1/770 14/18722 0.444661484993465 0.682188478978583 DDX3X 1 GO:1905049 negative regulation of metallopeptidase activity 1/770 14/18722 0.444661484993465 0.682188478978583 LRP1 1 GO:1905208 negative regulation of cardiocyte differentiation 1/770 14/18722 0.444661484993465 0.682188478978583 EGFR 1 GO:2001140 positive regulation of phospholipid transport 1/770 14/18722 0.444661484993465 0.682188478978583 PRELID1 1 GO:2001171 positive regulation of ATP biosynthetic process 1/770 14/18722 0.444661484993465 0.682188478978583 VCP 1 GO:0006352 DNA-templated transcription, initiation 6/770 130/18722 0.446070619109421 0.683718823445784 MED13/DHX36/GTF2B/TAF13/SUB1/PSMC6 6 GO:0030534 adult behavior 6/770 130/18722 0.446070619109421 0.683718823445784 APP/MAFG/CLCN3/CLN8/GIGYF2/PAFAH1B1 6 GO:0051028 mRNA transport 6/770 130/18722 0.446070619109421 0.683718823445784 MVP/RBM8A/SUPT6H/IWS1/EIF4A3/ALYREF 6 GO:0048678 response to axon injury 4/770 83/18722 0.446690992131587 0.684248759235075 BCL2/ARF4/LRP1/SOD1 4 GO:0051899 membrane depolarization 4/770 83/18722 0.446690992131587 0.684248759235075 PRKCZ/NEDD4L/BCL2/IFI6 4 GO:0034249 negative regulation of cellular amide metabolic process 12/770 273/18722 0.448650864035802 0.687039722031469 EIF2AK1/CPEB4/PAIP2/DHX36/GRB7/XRN1/DDX3X/GIGYF2/CALR/EIF4A3/ORMDL1/AGO2 12 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 3/770 60/18722 0.450579212092584 0.688149789526547 MBNL3/SAP18/RBM8A 3 GO:0006081 cellular aldehyde metabolic process 3/770 60/18722 0.450579212092584 0.688149789526547 RDH13/PDXK/RDH10 3 GO:0031102 neuron projection regeneration 3/770 60/18722 0.450579212092584 0.688149789526547 BCL2/LRP1/ADM 3 GO:0031638 zymogen activation 3/770 60/18722 0.450579212092584 0.688149789526547 CTSL/SERPINE1/FURIN 3 GO:0033866 nucleoside bisphosphate biosynthetic process 3/770 60/18722 0.450579212092584 0.688149789526547 SLC26A2/ACSS1/SLC25A16 3 GO:0034030 ribonucleoside bisphosphate biosynthetic process 3/770 60/18722 0.450579212092584 0.688149789526547 SLC26A2/ACSS1/SLC25A16 3 GO:0034033 purine nucleoside bisphosphate biosynthetic process 3/770 60/18722 0.450579212092584 0.688149789526547 SLC26A2/ACSS1/SLC25A16 3 GO:0042306 regulation of protein import into nucleus 3/770 60/18722 0.450579212092584 0.688149789526547 GLI3/JUP/UBR5 3 GO:0000018 regulation of DNA recombination 5/770 107/18722 0.450756755571875 0.688149789526547 TFRC/UBE2B/SUPT6H/PPP4R2/ALYREF 5 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 5/770 107/18722 0.450756755571875 0.688149789526547 HSPB1/APP/DDT/MIF/HSPD1 5 GO:0003016 respiratory system process 2/770 37/18722 0.453221157016827 0.689798724928176 STK40/ZFAND5 2 GO:0006862 nucleotide transport 2/770 37/18722 0.453221157016827 0.689798724928176 SLC19A1/SLC25A5 2 GO:0016202 regulation of striated muscle tissue development 2/770 37/18722 0.453221157016827 0.689798724928176 BCL2/CTNNB1 2 GO:0021532 neural tube patterning 2/770 37/18722 0.453221157016827 0.689798724928176 HES1/GLI3 2 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 2/770 37/18722 0.453221157016827 0.689798724928176 GATA3/CTNNB1 2 GO:0043029 T cell homeostasis 2/770 37/18722 0.453221157016827 0.689798724928176 PMAIP1/BCL2 2 GO:0043368 positive T cell selection 2/770 37/18722 0.453221157016827 0.689798724928176 CTSL/BCL2 2 GO:0051294 establishment of spindle orientation 2/770 37/18722 0.453221157016827 0.689798724928176 NUMA1/PAFAH1B1 2 GO:0060306 regulation of membrane repolarization 2/770 37/18722 0.453221157016827 0.689798724928176 NEDD4L/AKAP9 2 GO:0097484 dendrite extension 2/770 37/18722 0.453221157016827 0.689798724928176 NEDD4L/SPAG9 2 GO:0019827 stem cell population maintenance 6/770 131/18722 0.45336891736788 0.689812920685236 TBX3/NCOA3/HES1/HOOK3/GATA2/CTNNB1 6 GO:0007519 skeletal muscle tissue development 7/770 155/18722 0.455145878596668 0.690469803481889 NUPR1/MAFF/ATF3/BCL2/AKIRIN1/CTNNB1/HMG20B 7 GO:0002088 lens development in camera-type eye 4/770 84/18722 0.455846107114003 0.690469803481889 GATA3/TBC1D20/KDM5B/CTNNB1 4 GO:0032508 DNA duplex unwinding 4/770 84/18722 0.455846107114003 0.690469803481889 ANXA1/DHX36/DDX3X/CHD2 4 GO:0097061 dendritic spine organization 4/770 84/18722 0.455846107114003 0.690469803481889 DHX36/WASL/ARF1/PAFAH1B1 4 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 4/770 84/18722 0.455846107114003 0.690469803481889 BCL2/MDM2/CDK2/GIGYF2 4 GO:0001936 regulation of endothelial cell proliferation 8/770 179/18722 0.456395903371718 0.690469803481889 PGF/HMOX1/GATA2/PDPK1/RICTOR/NRP1/PDCD6/MYDGF 8 GO:0006941 striated muscle contraction 8/770 179/18722 0.456395903371718 0.690469803481889 ARG2/NEDD4L/DSP/EHD3/AKAP9/JUP/SLC9A1/PPP1R13L 8 GO:0007626 locomotory behavior 8/770 179/18722 0.456395903371718 0.690469803481889 ARRDC3/APP/CLCN3/ID2/CLN8/GIGYF2/PAFAH1B1/SOD1 8 GO:1901991 negative regulation of mitotic cell cycle phase transition 8/770 179/18722 0.456395903371718 0.690469803481889 NABP1/BCL2/FOXO4/MDM2/CDK2/GIGYF2/USP47/TAOK1 8 GO:0042255 ribosome assembly 3/770 61/18722 0.461375483012029 0.690469803481889 SBDS/DDX28/DDX3X 3 GO:0060997 dendritic spine morphogenesis 3/770 61/18722 0.461375483012029 0.690469803481889 DHX36/WASL/PAFAH1B1 3 GO:0090342 regulation of cell aging 3/770 61/18722 0.461375483012029 0.690469803481889 ARG2/LMNA/MIF 3 GO:2000401 regulation of lymphocyte migration 3/770 61/18722 0.461375483012029 0.690469803481889 APP/CD200/WASL 3 GO:0090257 regulation of muscle system process 11/770 252/18722 0.463656494439459 0.690469803481889 DSP/ANXA6/FBXO32/EHD3/AKAP9/JUP/PPP1R12B/LMNA/SLC9A1/ERRFI1/SOD1 11 GO:0002709 regulation of T cell mediated immunity 4/770 85/18722 0.464950100188766 0.690469803481889 PRKCZ/GATA3/CD55/HSPD1 4 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 4/770 85/18722 0.464950100188766 0.690469803481889 HES1/GHR/SOCS1/OSBP 4 GO:0045069 regulation of viral genome replication 4/770 85/18722 0.464950100188766 0.690469803481889 BCL2/DDB1/DDX3X/STAU1 4 GO:0071277 cellular response to calcium ion 4/770 85/18722 0.464950100188766 0.690469803481889 BRAF/JUND/HSPA5/SYT7 4 GO:2000779 regulation of double-strand break repair 4/770 85/18722 0.464950100188766 0.690469803481889 OTUB2/SPIRE2/UBR5/PPP4R2 4 GO:0046700 heterocycle catabolic process 19/770 445/18722 0.466879174747085 0.690469803481889 HMOX1/KMO/PNP/ETF1/ERN1/VCP/DHX36/RNASEH2C/DEDD2/MTHFS/LARP4B/TET2/RBM8A/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2/NFE2L2 19 GO:0008210 estrogen metabolic process 2/770 38/18722 0.467036550310354 0.690469803481889 CYP19A1/HSD17B1 2 GO:0010719 negative regulation of epithelial to mesenchymal transition 2/770 38/18722 0.467036550310354 0.690469803481889 GATA3/ZNF750 2 GO:0010742 macrophage derived foam cell differentiation 2/770 38/18722 0.467036550310354 0.690469803481889 NFKBIA/ABCG1 2 GO:0032717 negative regulation of interleukin-8 production 2/770 38/18722 0.467036550310354 0.690469803481889 ANXA1/ANXA4 2 GO:0032941 secretion by tissue 2/770 38/18722 0.467036550310354 0.690469803481889 EGFR/KCNN4 2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2/770 38/18722 0.467036550310354 0.690469803481889 DAB2/CALR 2 GO:0090077 foam cell differentiation 2/770 38/18722 0.467036550310354 0.690469803481889 NFKBIA/ABCG1 2 GO:1903725 regulation of phospholipid metabolic process 2/770 38/18722 0.467036550310354 0.690469803481889 ARF1/LDLR 2 GO:0002070 epithelial cell maturation 1/770 15/18722 0.467518586583964 0.690469803481889 AKR1B1 1 GO:0002730 regulation of dendritic cell cytokine production 1/770 15/18722 0.467518586583964 0.690469803481889 DHX36 1 GO:0003356 regulation of cilium beat frequency 1/770 15/18722 0.467518586583964 0.690469803481889 CCSAP 1 GO:0006684 sphingomyelin metabolic process 1/770 15/18722 0.467518586583964 0.690469803481889 SAMD8 1 GO:0006825 copper ion transport 1/770 15/18722 0.467518586583964 0.690469803481889 COX17 1 GO:0009083 branched-chain amino acid catabolic process 1/770 15/18722 0.467518586583964 0.690469803481889 HIBADH 1 GO:0009163 nucleoside biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 PNP 1 GO:0010832 negative regulation of myotube differentiation 1/770 15/18722 0.467518586583964 0.690469803481889 HDAC5 1 GO:0014048 regulation of glutamate secretion 1/770 15/18722 0.467518586583964 0.690469803481889 KMO 1 GO:0016114 terpenoid biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 RDH10 1 GO:0018146 keratan sulfate biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 ST3GAL4 1 GO:0018298 protein-chromophore linkage 1/770 15/18722 0.467518586583964 0.690469803481889 OPN3 1 GO:0031269 pseudopodium assembly 1/770 15/18722 0.467518586583964 0.690469803481889 CDC42EP4 1 GO:0031958 corticosteroid receptor signaling pathway 1/770 15/18722 0.467518586583964 0.690469803481889 CALR 1 GO:0032328 alanine transport 1/770 15/18722 0.467518586583964 0.690469803481889 SLC3A2 1 GO:0032354 response to follicle-stimulating hormone 1/770 15/18722 0.467518586583964 0.690469803481889 TGFBR3 1 GO:0032488 Cdc42 protein signal transduction 1/770 15/18722 0.467518586583964 0.690469803481889 NRP1 1 GO:0032897 negative regulation of viral transcription 1/770 15/18722 0.467518586583964 0.690469803481889 HEXIM1 1 GO:0032933 SREBP signaling pathway 1/770 15/18722 0.467518586583964 0.690469803481889 INSIG1 1 GO:0034384 high-density lipoprotein particle clearance 1/770 15/18722 0.467518586583964 0.690469803481889 LDLR 1 GO:0034404 nucleobase-containing small molecule biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 PNP 1 GO:0035435 phosphate ion transmembrane transport 1/770 15/18722 0.467518586583964 0.690469803481889 SLC20A1 1 GO:0035493 SNARE complex assembly 1/770 15/18722 0.467518586583964 0.690469803481889 UVRAG 1 GO:0035627 ceramide transport 1/770 15/18722 0.467518586583964 0.690469803481889 GLTP 1 GO:0036124 histone H3-K9 trimethylation 1/770 15/18722 0.467518586583964 0.690469803481889 LMNA 1 GO:0036376 sodium ion export across plasma membrane 1/770 15/18722 0.467518586583964 0.690469803481889 SLC9A1 1 GO:0042074 cell migration involved in gastrulation 1/770 15/18722 0.467518586583964 0.690469803481889 GPC3 1 GO:0042159 lipoprotein catabolic process 1/770 15/18722 0.467518586583964 0.690469803481889 LDLR 1 GO:0042559 pteridine-containing compound biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 MTHFS 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/770 15/18722 0.467518586583964 0.690469803481889 NFKBIA 1 GO:0044793 negative regulation by host of viral process 1/770 15/18722 0.467518586583964 0.690469803481889 PSMC3 1 GO:0045475 locomotor rhythm 1/770 15/18722 0.467518586583964 0.690469803481889 ID2 1 GO:0045836 positive regulation of meiotic nuclear division 1/770 15/18722 0.467518586583964 0.690469803481889 UBE2B 1 GO:0045986 negative regulation of smooth muscle contraction 1/770 15/18722 0.467518586583964 0.690469803481889 SOD1 1 GO:0046007 negative regulation of activated T cell proliferation 1/770 15/18722 0.467518586583964 0.690469803481889 CD274 1 GO:0046184 aldehyde biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 PDXK 1 GO:0046459 short-chain fatty acid metabolic process 1/770 15/18722 0.467518586583964 0.690469803481889 ACSS1 1 GO:0048569 post-embryonic animal organ development 1/770 15/18722 0.467518586583964 0.690469803481889 EFEMP1 1 GO:0048712 negative regulation of astrocyte differentiation 1/770 15/18722 0.467518586583964 0.690469803481889 LDLR 1 GO:0051608 histamine transport 1/770 15/18722 0.467518586583964 0.690469803481889 SNAP23 1 GO:0051791 medium-chain fatty acid metabolic process 1/770 15/18722 0.467518586583964 0.690469803481889 ABHD3 1 GO:0051938 L-glutamate import 1/770 15/18722 0.467518586583964 0.690469803481889 CLN8 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/770 15/18722 0.467518586583964 0.690469803481889 LMNA 1 GO:0055091 phospholipid homeostasis 1/770 15/18722 0.467518586583964 0.690469803481889 ABCG1 1 GO:0060099 regulation of phagocytosis, engulfment 1/770 15/18722 0.467518586583964 0.690469803481889 GATA2 1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/770 15/18722 0.467518586583964 0.690469803481889 AGO2 1 GO:0060253 negative regulation of glial cell proliferation 1/770 15/18722 0.467518586583964 0.690469803481889 HES1 1 GO:0060766 negative regulation of androgen receptor signaling pathway 1/770 15/18722 0.467518586583964 0.690469803481889 DAB2 1 GO:0070207 protein homotrimerization 1/770 15/18722 0.467518586583964 0.690469803481889 MIF 1 GO:0070831 basement membrane assembly 1/770 15/18722 0.467518586583964 0.690469803481889 PHLDB2 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/770 15/18722 0.467518586583964 0.690469803481889 SLC9A1 1 GO:0071025 RNA surveillance 1/770 15/18722 0.467518586583964 0.690469803481889 XRN1 1 GO:0071380 cellular response to prostaglandin E stimulus 1/770 15/18722 0.467518586583964 0.690469803481889 P2RY6 1 GO:0071599 otic vesicle development 1/770 15/18722 0.467518586583964 0.690469803481889 GATA3 1 GO:0071871 response to epinephrine 1/770 15/18722 0.467518586583964 0.690469803481889 SLC9A1 1 GO:0072075 metanephric mesenchyme development 1/770 15/18722 0.467518586583964 0.690469803481889 BASP1 1 GO:0072224 metanephric glomerulus development 1/770 15/18722 0.467518586583964 0.690469803481889 LGR4 1 GO:0090594 inflammatory response to wounding 1/770 15/18722 0.467518586583964 0.690469803481889 HMOX1 1 GO:0098712 L-glutamate import across plasma membrane 1/770 15/18722 0.467518586583964 0.690469803481889 CLN8 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/770 15/18722 0.467518586583964 0.690469803481889 SLC9A1 1 GO:1900029 positive regulation of ruffle assembly 1/770 15/18722 0.467518586583964 0.690469803481889 EPS8L1 1 GO:1901741 positive regulation of myoblast fusion 1/770 15/18722 0.467518586583964 0.690469803481889 GDF15 1 GO:1902018 negative regulation of cilium assembly 1/770 15/18722 0.467518586583964 0.690469803481889 LIMK2 1 GO:1904380 endoplasmic reticulum mannose trimming 1/770 15/18722 0.467518586583964 0.690469803481889 EDEM1 1 GO:1904424 regulation of GTP binding 1/770 15/18722 0.467518586583964 0.690469803481889 CSNK1A1 1 GO:1905288 vascular associated smooth muscle cell apoptotic process 1/770 15/18722 0.467518586583964 0.690469803481889 PDCD4 1 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 1/770 15/18722 0.467518586583964 0.690469803481889 PDCD4 1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1/770 15/18722 0.467518586583964 0.690469803481889 NEDD4L 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/770 15/18722 0.467518586583964 0.690469803481889 HSPB1 1 GO:2001138 regulation of phospholipid transport 1/770 15/18722 0.467518586583964 0.690469803481889 PRELID1 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/770 15/18722 0.467518586583964 0.690469803481889 ANXA1 1 GO:0097696 receptor signaling pathway via STAT 8/770 181/18722 0.468828962405435 0.692199916938158 AKR1B1/HES1/GHR/SOCS1/LEPROT/IL10RB/PRLR/OSBP 8 GO:0031124 mRNA 3'-end processing 3/770 62/18722 0.472078941218427 0.695144611138128 PAPOLA/APP/DHX36 3 GO:0045428 regulation of nitric oxide biosynthetic process 3/770 62/18722 0.472078941218427 0.695144611138128 GLA/DYNLL1/HSP90AA1 3 GO:0046148 pigment biosynthetic process 3/770 62/18722 0.472078941218427 0.695144611138128 ALAS1/OPN3/DDT 3 GO:0046173 polyol biosynthetic process 3/770 62/18722 0.472078941218427 0.695144611138128 AKR1B1/P2RY6/ISYNA1 3 GO:0048002 antigen processing and presentation of peptide antigen 3/770 62/18722 0.472078941218427 0.695144611138128 CTSL/SAR1B/CALR 3 GO:0048488 synaptic vesicle endocytosis 3/770 62/18722 0.472078941218427 0.695144611138128 OPHN1/SYNJ1/AP2M1 3 GO:0048663 neuron fate commitment 3/770 62/18722 0.472078941218427 0.695144611138128 GLI3/GATA2/ID2 3 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 3/770 62/18722 0.472078941218427 0.695144611138128 GDF15/DAB2/LRP1 3 GO:0140238 presynaptic endocytosis 3/770 62/18722 0.472078941218427 0.695144611138128 OPHN1/SYNJ1/AP2M1 3 GO:0051056 regulation of small GTPase mediated signal transduction 13/770 302/18722 0.473385684374179 0.696862884855696 SQSTM1/EPS8L1/FAM13A/RASA1/VAV3/TGM2/ARHGAP24/OPHN1/ADGRG1/KANK1/NRP1/LRRC59/ARHGAP18 13 GO:0006401 RNA catabolic process 12/770 278/18722 0.47377888875367 0.697235736166431 ETF1/ERN1/DHX36/RNASEH2C/DEDD2/LARP4B/RBM8A/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2 12 GO:0006493 protein O-linked glycosylation 4/770 86/18722 0.473999292995838 0.697354141422574 ST3GAL4/B3GNT5/C1GALT1/TET2 4 GO:0001508 action potential 6/770 134/18722 0.475122081839961 0.698227226991088 NEDD4L/DSP/AKAP9/JUP/CLN3/SLC9A1 6 GO:0002705 positive regulation of leukocyte mediated immunity 6/770 134/18722 0.475122081839961 0.698227226991088 PRKCZ/TFRC/GATA3/CD55/DHX36/HSPD1 6 GO:0098727 maintenance of cell number 6/770 134/18722 0.475122081839961 0.698227226991088 TBX3/NCOA3/HES1/HOOK3/GATA2/CTNNB1 6 GO:0018393 internal peptidyl-lysine acetylation 7/770 158/18722 0.475153226314826 0.698227226991088 GATA3/NCOA3/MBD3/GATA2/GTF2B/IWS1/RPS6KA5 7 GO:0002347 response to tumor cell 2/770 39/18722 0.480642107135069 0.704262207237839 CD274/HSPD1 2 GO:0021587 cerebellum morphogenesis 2/770 39/18722 0.480642107135069 0.704262207237839 OPHN1/HSPA5 2 GO:0045622 regulation of T-helper cell differentiation 2/770 39/18722 0.480642107135069 0.704262207237839 ANXA1/PRKCZ 2 GO:0046461 neutral lipid catabolic process 2/770 39/18722 0.480642107135069 0.704262207237839 ABHD5/PNPLA2 2 GO:0046464 acylglycerol catabolic process 2/770 39/18722 0.480642107135069 0.704262207237839 ABHD5/PNPLA2 2 GO:1901861 regulation of muscle tissue development 2/770 39/18722 0.480642107135069 0.704262207237839 BCL2/CTNNB1 2 GO:2000249 regulation of actin cytoskeleton reorganization 2/770 39/18722 0.480642107135069 0.704262207237839 NRP1/IQGAP2 2 GO:0032233 positive regulation of actin filament bundle assembly 3/770 63/18722 0.482684561633395 0.704262207237839 MTSS1/NRP1/FERMT2 3 GO:0050854 regulation of antigen receptor-mediated signaling pathway 3/770 63/18722 0.482684561633395 0.704262207237839 EZR/KCNN4/DUSP3 3 GO:0099601 regulation of neurotransmitter receptor activity 3/770 63/18722 0.482684561633395 0.704262207237839 APP/AKAP9/KLHL24 3 GO:2000242 negative regulation of reproductive process 3/770 63/18722 0.482684561633395 0.704262207237839 OVOL1/CALR/SERPINF1 3 GO:0015718 monocarboxylic acid transport 5/770 111/18722 0.482761146351497 0.704262207237839 ANXA1/SLC6A8/SLC5A6/PNPLA8/SLC16A3 5 GO:0090288 negative regulation of cellular response to growth factor stimulus 5/770 111/18722 0.482761146351497 0.704262207237839 SEMA6A/GREM2/GATA3/CRIM1/PDCD6 5 GO:1901879 regulation of protein depolymerization 4/770 87/18722 0.482990169890257 0.704262207237839 SCIN/ATXN7/CAMSAP2/TAOK1 4 GO:1903522 regulation of blood circulation 11/770 256/18722 0.484608209390468 0.704262207237839 EGFR/CYP2J2/HOPX/DSP/EPAS1/EHD3/AKAP9/JUP/MDM2/SLC9A1/ADM 11 GO:0006402 mRNA catabolic process 10/770 232/18722 0.485476694289738 0.704262207237839 ETF1/ERN1/DHX36/LARP4B/RBM8A/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2 10 GO:0006475 internal protein amino acid acetylation 7/770 160/18722 0.488386174079743 0.704262207237839 GATA3/NCOA3/MBD3/GATA2/GTF2B/IWS1/RPS6KA5 7 GO:0035637 multicellular organismal signaling 7/770 160/18722 0.488386174079743 0.704262207237839 DSP/EHD3/AKAP9/JUP/SLC9A1/PAFAH1B1/SOD1 7 GO:0001977 renal system process involved in regulation of blood volume 1/770 16/18722 0.48943608743019 0.704262207237839 HSD11B2 1 GO:0002093 auditory receptor cell morphogenesis 1/770 16/18722 0.48943608743019 0.704262207237839 SOD1 1 GO:0002371 dendritic cell cytokine production 1/770 16/18722 0.48943608743019 0.704262207237839 DHX36 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/770 16/18722 0.48943608743019 0.704262207237839 HSD11B2 1 GO:0005980 glycogen catabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 PPP1CB 1 GO:0006004 fucose metabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 FUCA1 1 GO:0006555 methionine metabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 SMS 1 GO:0006750 glutathione biosynthetic process 1/770 16/18722 0.48943608743019 0.704262207237839 NFE2L2 1 GO:0006857 oligopeptide transport 1/770 16/18722 0.48943608743019 0.704262207237839 SLC13A3 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/770 16/18722 0.48943608743019 0.704262207237839 CDYL 1 GO:0009074 aromatic amino acid family catabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 KMO 1 GO:0009111 vitamin catabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 MTHFS 1 GO:0009299 mRNA transcription 1/770 16/18722 0.48943608743019 0.704262207237839 SUPT6H 1 GO:0009642 response to light intensity 1/770 16/18722 0.48943608743019 0.704262207237839 RDH13 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/770 16/18722 0.48943608743019 0.704262207237839 P2RY6 1 GO:0030033 microvillus assembly 1/770 16/18722 0.48943608743019 0.704262207237839 EZR 1 GO:0030540 female genitalia development 1/770 16/18722 0.48943608743019 0.704262207237839 TBX3 1 GO:0031268 pseudopodium organization 1/770 16/18722 0.48943608743019 0.704262207237839 CDC42EP4 1 GO:0033631 cell-cell adhesion mediated by integrin 1/770 16/18722 0.48943608743019 0.704262207237839 PLPP3 1 GO:0034138 toll-like receptor 3 signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 COLEC12 1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 1/770 16/18722 0.48943608743019 0.704262207237839 HEXIM1 1 GO:0034374 low-density lipoprotein particle remodeling 1/770 16/18722 0.48943608743019 0.704262207237839 ABCG1 1 GO:0034375 high-density lipoprotein particle remodeling 1/770 16/18722 0.48943608743019 0.704262207237839 ABCG1 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/770 16/18722 0.48943608743019 0.704262207237839 PDCD4 1 GO:0035864 response to potassium ion 1/770 16/18722 0.48943608743019 0.704262207237839 SOD1 1 GO:0035970 peptidyl-threonine dephosphorylation 1/770 16/18722 0.48943608743019 0.704262207237839 DUSP5 1 GO:0042481 regulation of odontogenesis 1/770 16/18722 0.48943608743019 0.704262207237839 SP6 1 GO:0045651 positive regulation of macrophage differentiation 1/770 16/18722 0.48943608743019 0.704262207237839 ID2 1 GO:0045722 positive regulation of gluconeogenesis 1/770 16/18722 0.48943608743019 0.704262207237839 DDB1 1 GO:0045838 positive regulation of membrane potential 1/770 16/18722 0.48943608743019 0.704262207237839 VCP 1 GO:0046037 GMP metabolic process 1/770 16/18722 0.48943608743019 0.704262207237839 MPP1 1 GO:0048385 regulation of retinoic acid receptor signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 CALR 1 GO:0050862 positive regulation of T cell receptor signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 KCNN4 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/770 16/18722 0.48943608743019 0.704262207237839 NR2F6 1 GO:0051014 actin filament severing 1/770 16/18722 0.48943608743019 0.704262207237839 SCIN 1 GO:0060330 regulation of response to interferon-gamma 1/770 16/18722 0.48943608743019 0.704262207237839 SOCS1 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 SOCS1 1 GO:0070242 thymocyte apoptotic process 1/770 16/18722 0.48943608743019 0.704262207237839 GLI3 1 GO:0071501 cellular response to sterol depletion 1/770 16/18722 0.48943608743019 0.704262207237839 INSIG1 1 GO:0071732 cellular response to nitric oxide 1/770 16/18722 0.48943608743019 0.704262207237839 CDK2 1 GO:0072148 epithelial cell fate commitment 1/770 16/18722 0.48943608743019 0.704262207237839 NRP1 1 GO:0090520 sphingolipid mediated signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 EZR 1 GO:0099633 protein localization to postsynaptic specialization membrane 1/770 16/18722 0.48943608743019 0.704262207237839 PRKCZ 1 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 1/770 16/18722 0.48943608743019 0.704262207237839 PRKCZ 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 SEMA6A 1 GO:1901201 regulation of extracellular matrix assembly 1/770 16/18722 0.48943608743019 0.704262207237839 PHLDB2 1 GO:1902931 negative regulation of alcohol biosynthetic process 1/770 16/18722 0.48943608743019 0.704262207237839 SOD1 1 GO:1903236 regulation of leukocyte tethering or rolling 1/770 16/18722 0.48943608743019 0.704262207237839 ST3GAL4 1 GO:1905153 regulation of membrane invagination 1/770 16/18722 0.48943608743019 0.704262207237839 GATA2 1 GO:2000001 regulation of DNA damage checkpoint 1/770 16/18722 0.48943608743019 0.704262207237839 PPP1R10 1 GO:2000846 regulation of corticosteroid hormone secretion 1/770 16/18722 0.48943608743019 0.704262207237839 C1QTNF1 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/770 16/18722 0.48943608743019 0.704262207237839 CD63 1 GO:2001212 regulation of vasculogenesis 1/770 16/18722 0.48943608743019 0.704262207237839 ADM 1 GO:2001224 positive regulation of neuron migration 1/770 16/18722 0.48943608743019 0.704262207237839 SEMA6A 1 GO:0032609 interferon-gamma production 5/770 112/18722 0.49066419843689 0.705621847275909 GATA3/DDIT3/SLC7A5/CD274/HSPD1 5 GO:0032649 regulation of interferon-gamma production 5/770 112/18722 0.49066419843689 0.705621847275909 GATA3/DDIT3/SLC7A5/CD274/HSPD1 5 GO:0007260 tyrosine phosphorylation of STAT protein 4/770 88/18722 0.491919376447742 0.706814951799048 HES1/GHR/SOCS1/OSBP 4 GO:0030101 natural killer cell activation 4/770 88/18722 0.491919376447742 0.706814951799048 SNX27/HECTD1/NFIL3/PBX1 4 GO:1901657 glycosyl compound metabolic process 4/770 88/18722 0.491919376447742 0.706814951799048 AKR1B1/PNP/FUCA1/GLA 4 GO:0055002 striated muscle cell development 3/770 64/18722 0.493187657233788 0.708012650378373 SDC1/KRT8/NEBL 3 GO:0080164 regulation of nitric oxide metabolic process 3/770 64/18722 0.493187657233788 0.708012650378373 GLA/DYNLL1/HSP90AA1 3 GO:0009069 serine family amino acid metabolic process 2/770 40/18722 0.494031704869678 0.708012650378373 SERINC5/CDO1 2 GO:0010863 positive regulation of phospholipase C activity 2/770 40/18722 0.494031704869678 0.708012650378373 EGFR/P2RY6 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/770 40/18722 0.494031704869678 0.708012650378373 LGR4/PDPK1 2 GO:0045740 positive regulation of DNA replication 2/770 40/18722 0.494031704869678 0.708012650378373 EGFR/ATF1 2 GO:0045777 positive regulation of blood pressure 2/770 40/18722 0.494031704869678 0.708012650378373 HSD11B2/ID2 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/770 40/18722 0.494031704869678 0.708012650378373 P2RY6/PDPK1 2 GO:1901661 quinone metabolic process 2/770 40/18722 0.494031704869678 0.708012650378373 AKR1B1/COQ10B 2 GO:0002708 positive regulation of lymphocyte mediated immunity 5/770 113/18722 0.498523053701856 0.714243926565942 PRKCZ/TFRC/GATA3/CD55/HSPD1 5 GO:0008217 regulation of blood pressure 8/770 186/18722 0.499614614593315 0.715190929192327 HMOX1/SGK1/HSD11B2/MME/ID2/ENPEP/ADM/SOD1 8 GO:0071706 tumor necrosis factor superfamily cytokine production 8/770 186/18722 0.499614614593315 0.715190929192327 HSPB1/ARG2/APP/CD274/DDT/MIF/ERRFI1/HSPD1 8 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 8/770 186/18722 0.499614614593315 0.715190929192327 HSPB1/ARG2/APP/CD274/DDT/MIF/ERRFI1/HSPD1 8 GO:0051494 negative regulation of cytoskeleton organization 7/770 162/18722 0.501520193839359 0.71751343496055 SCIN/ATXN7/PHLDB2/PPFIA1/KANK1/CAMSAP2/TAOK1 7 GO:0003170 heart valve development 3/770 65/18722 0.503583869302937 0.71751343496055 GATA3/HECTD1/MDM2 3 GO:0033692 cellular polysaccharide biosynthetic process 3/770 65/18722 0.503583869302937 0.71751343496055 IRS2/SORBS1/PPP1CB 3 GO:0045453 bone resorption 3/770 65/18722 0.503583869302937 0.71751343496055 TFRC/EGFR/CTNNB1 3 GO:0061512 protein localization to cilium 3/770 65/18722 0.503583869302937 0.71751343496055 ATP6V1D/ARF4/ZDHHC3 3 GO:0071677 positive regulation of mononuclear cell migration 3/770 65/18722 0.503583869302937 0.71751343496055 APP/SERPINE1/CALR 3 GO:1905330 regulation of morphogenesis of an epithelium 3/770 65/18722 0.503583869302937 0.71751343496055 GATA3/LGR4/CTNNB1 3 GO:0001818 negative regulation of cytokine production 15/770 357/18722 0.503688546319019 0.71751343496055 ANXA1/HMOX1/PDCD4/GATA3/ARG2/EZR/DDIT3/LGR4/CD200/CD274/FURIN/TNFRSF21/ANXA4/RPS6KA5/ERRFI1 15 GO:0019751 polyol metabolic process 5/770 114/18722 0.506335380729337 0.71751343496055 AKR1B1/PLPP3/P2RY6/ISYNA1/SYNJ1 5 GO:0048634 regulation of muscle organ development 2/770 41/18722 0.507200077762152 0.71751343496055 BCL2/CTNNB1 2 GO:0050892 intestinal absorption 2/770 41/18722 0.507200077762152 0.71751343496055 EZR/LDLR 2 GO:0046395 carboxylic acid catabolic process 10/770 236/18722 0.507278075296132 0.71751343496055 KMO/ARG2/ABHD3/MTHFS/PPARD/IRS2/ACADVL/HIBADH/AIG1/CDO1 10 GO:0006633 fatty acid biosynthetic process 7/770 163/18722 0.508046358869421 0.71751343496055 ANXA1/ABHD3/ACSS1/PNPLA8/ACADVL/MIF/INSIG1 7 GO:0046031 ADP metabolic process 4/770 90/18722 0.50958015637339 0.71751343496055 NUPR1/APP/AK3/BPGM 4 GO:0042113 B cell activation 14/770 334/18722 0.50977014556795 0.71751343496055 TFRC/VAV3/BCL2/HDAC5/ID2/DNAJB9/SLC25A5/TNFRSF21/TPD52/IRS2/FNIP1/SUPT6H/MIF/HSPD1 14 GO:0000097 sulfur amino acid biosynthetic process 1/770 17/18722 0.510452564104987 0.71751343496055 CDO1 1 GO:0001780 neutrophil homeostasis 1/770 17/18722 0.510452564104987 0.71751343496055 ANXA1 1 GO:0001829 trophectodermal cell differentiation 1/770 17/18722 0.510452564104987 0.71751343496055 HOPX 1 GO:0002031 G protein-coupled receptor internalization 1/770 17/18722 0.510452564104987 0.71751343496055 ADM 1 GO:0006677 glycosylceramide metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 GLA 1 GO:0006744 ubiquinone biosynthetic process 1/770 17/18722 0.510452564104987 0.71751343496055 COQ10B 1 GO:0006895 Golgi to endosome transport 1/770 17/18722 0.510452564104987 0.71751343496055 AP2A1 1 GO:0008334 histone mRNA metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 XRN1 1 GO:0009084 glutamine family amino acid biosynthetic process 1/770 17/18722 0.510452564104987 0.71751343496055 CLN3 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 PNP 1 GO:0009251 glucan catabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 PPP1CB 1 GO:0010470 regulation of gastrulation 1/770 17/18722 0.510452564104987 0.71751343496055 PHLDB2 1 GO:0010566 regulation of ketone biosynthetic process 1/770 17/18722 0.510452564104987 0.71751343496055 ADM 1 GO:0010715 regulation of extracellular matrix disassembly 1/770 17/18722 0.510452564104987 0.71751343496055 LRP1 1 GO:0010934 macrophage cytokine production 1/770 17/18722 0.510452564104987 0.71751343496055 SEMA7A 1 GO:0010935 regulation of macrophage cytokine production 1/770 17/18722 0.510452564104987 0.71751343496055 SEMA7A 1 GO:0015867 ATP transport 1/770 17/18722 0.510452564104987 0.71751343496055 SLC25A5 1 GO:0021513 spinal cord dorsal/ventral patterning 1/770 17/18722 0.510452564104987 0.71751343496055 GLI3 1 GO:0030322 stabilization of membrane potential 1/770 17/18722 0.510452564104987 0.71751343496055 KCNN4 1 GO:0032048 cardiolipin metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 PNPLA8 1 GO:0034349 glial cell apoptotic process 1/770 17/18722 0.510452564104987 0.71751343496055 TNFRSF21 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/770 17/18722 0.510452564104987 0.71751343496055 NRP1 1 GO:0036035 osteoclast development 1/770 17/18722 0.510452564104987 0.71751343496055 PAFAH1B1 1 GO:0042339 keratan sulfate metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 ST3GAL4 1 GO:0042448 progesterone metabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 ADM 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/770 17/18722 0.510452564104987 0.71751343496055 SOCS1 1 GO:0042953 lipoprotein transport 1/770 17/18722 0.510452564104987 0.71751343496055 LRP1 1 GO:0043649 dicarboxylic acid catabolic process 1/770 17/18722 0.510452564104987 0.71751343496055 MTHFS 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/770 17/18722 0.510452564104987 0.71751343496055 OPHN1 1 GO:0045815 positive regulation of gene expression, epigenetic 1/770 17/18722 0.510452564104987 0.71751343496055 SERTAD1 1 GO:0046827 positive regulation of protein export from nucleus 1/770 17/18722 0.510452564104987 0.71751343496055 MDM2 1 GO:0046855 inositol phosphate dephosphorylation 1/770 17/18722 0.510452564104987 0.71751343496055 SYNJ1 1 GO:0048521 negative regulation of behavior 1/770 17/18722 0.510452564104987 0.71751343496055 ARRDC3 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/770 17/18722 0.510452564104987 0.71751343496055 SYT7 1 GO:0051797 regulation of hair follicle development 1/770 17/18722 0.510452564104987 0.71751343496055 NUMA1 1 GO:0055003 cardiac myofibril assembly 1/770 17/18722 0.510452564104987 0.71751343496055 NEBL 1 GO:0055064 chloride ion homeostasis 1/770 17/18722 0.510452564104987 0.71751343496055 SLC12A4 1 GO:0055083 monovalent inorganic anion homeostasis 1/770 17/18722 0.510452564104987 0.71751343496055 SLC12A4 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/770 17/18722 0.510452564104987 0.71751343496055 DHX36 1 GO:0061298 retina vasculature development in camera-type eye 1/770 17/18722 0.510452564104987 0.71751343496055 NRP1 1 GO:0070206 protein trimerization 1/770 17/18722 0.510452564104987 0.71751343496055 MIF 1 GO:0070593 dendrite self-avoidance 1/770 17/18722 0.510452564104987 0.71751343496055 BSG 1 GO:0072673 lamellipodium morphogenesis 1/770 17/18722 0.510452564104987 0.71751343496055 KANK1 1 GO:0090713 immunological memory process 1/770 17/18722 0.510452564104987 0.71751343496055 CD46 1 GO:0097067 cellular response to thyroid hormone stimulus 1/770 17/18722 0.510452564104987 0.71751343496055 CTSL 1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 1/770 17/18722 0.510452564104987 0.71751343496055 AKAP9 1 GO:1901663 quinone biosynthetic process 1/770 17/18722 0.510452564104987 0.71751343496055 COQ10B 1 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 1/770 17/18722 0.510452564104987 0.71751343496055 PPARD 1 GO:2000811 negative regulation of anoikis 1/770 17/18722 0.510452564104987 0.71751343496055 BCL2 1 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 3/770 66/18722 0.51386915752159 0.721705189382774 TFRC/SUPT6H/HSPD1 3 GO:0016444 somatic cell DNA recombination 3/770 66/18722 0.51386915752159 0.721705189382774 TFRC/SUPT6H/HSPD1 3 GO:0042093 T-helper cell differentiation 3/770 66/18722 0.51386915752159 0.721705189382774 ANXA1/PRKCZ/GATA3 3 GO:0019935 cyclic-nucleotide-mediated signaling 4/770 91/18722 0.518305810384762 0.726374937235179 UBE2B/GNAI1/CAP2/ADM 4 GO:0140014 mitotic nuclear division 12/770 287/18722 0.518447257313448 0.726374937235179 RAB11A/GOLGA2/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CHMP4B/EML4/USP16/CHMP2A/UBE2I 12 GO:0008380 RNA splicing 18/770 434/18722 0.519819099892962 0.726374937235179 MBNL3/SAP18/RRAGC/ERN1/HNRNPH2/RBM8A/RBM42/SRSF5/CWC25/SUPT6H/IWS1/EIF4A3/MFAP1/PRDX6/PPP4R2/ALYREF/HSPA8/SRRM2 18 GO:0042391 regulation of membrane potential 18/770 434/18722 0.519819099892962 0.726374937235179 PRKCZ/PMAIP1/NEDD4L/APP/KCNN4/DSP/BCL2/GABRE/IFI6/VCP/EHD3/AKAP9/JUP/CLN3/PRELID1/EIF4A3/SLC9A1/SOD1 18 GO:0000413 protein peptidyl-prolyl isomerization 2/770 42/18722 0.520142756966341 0.726374937235179 FKBP2/PPIB 2 GO:0030574 collagen catabolic process 2/770 42/18722 0.520142756966341 0.726374937235179 CTSL/FURIN 2 GO:0033574 response to testosterone 2/770 42/18722 0.520142756966341 0.726374937235179 XRN1/CALR 2 GO:0035019 somatic stem cell population maintenance 2/770 42/18722 0.520142756966341 0.726374937235179 HES1/GATA2 2 GO:0042168 heme metabolic process 2/770 42/18722 0.520142756966341 0.726374937235179 HMOX1/ALAS1 2 GO:0051602 response to electrical stimulus 2/770 42/18722 0.520142756966341 0.726374937235179 AKAP9/SLC9A1 2 GO:0071312 cellular response to alkaloid 2/770 42/18722 0.520142756966341 0.726374937235179 TGM2/MDM2 2 GO:0090317 negative regulation of intracellular protein transport 2/770 42/18722 0.520142756966341 0.726374937235179 ERLEC1/INSIG1 2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 2/770 42/18722 0.520142756966341 0.726374937235179 REXO2/XRN1 2 GO:1900274 regulation of phospholipase C activity 2/770 42/18722 0.520142756966341 0.726374937235179 EGFR/P2RY6 2 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 2/770 42/18722 0.520142756966341 0.726374937235179 GATA3/GATA2 2 GO:1903432 regulation of TORC1 signaling 2/770 42/18722 0.520142756966341 0.726374937235179 RRAGC/SIK3 2 GO:2000404 regulation of T cell migration 2/770 42/18722 0.520142756966341 0.726374937235179 APP/CD200 2 GO:2001222 regulation of neuron migration 2/770 42/18722 0.520142756966341 0.726374937235179 SEMA6A/ADGRG1 2 GO:0033559 unsaturated fatty acid metabolic process 5/770 116/18722 0.521811573302884 0.726374937235179 ANXA1/CYP2J2/AKR1B1/PNPLA8/MIF 5 GO:1990748 cellular detoxification 5/770 116/18722 0.521811573302884 0.726374937235179 GPX3/MGST3/PRDX6/SOD1/NFE2L2 5 GO:0051216 cartilage development 8/770 190/18722 0.523853658637579 0.726374937235179 SCIN/ANXA6/GLI3/GHR/CREB3L2/TRIP11/CTNNB1/EFEMP1 8 GO:0016445 somatic diversification of immunoglobulins 3/770 67/18722 0.524039789944025 0.726374937235179 TFRC/SUPT6H/HSPD1 3 GO:0032890 regulation of organic acid transport 3/770 67/18722 0.524039789944025 0.726374937235179 KMO/SLC43A2/IRS2 3 GO:0050435 amyloid-beta metabolic process 3/770 67/18722 0.524039789944025 0.726374937235179 BACE2/MME/ABCG1 3 GO:1902117 positive regulation of organelle assembly 3/770 67/18722 0.524039789944025 0.726374937235179 SDC1/NUMA1/VPS4B 3 GO:0050921 positive regulation of chemotaxis 6/770 141/18722 0.524797364712223 0.726374937235179 PGF/HSPB1/SERPINE1/AKIRIN1/CALR/NRP1 6 GO:0001708 cell fate specification 4/770 92/18722 0.526957950885623 0.726374937235179 TBX3/GLI3/CTNNB1/NRP1 4 GO:0016054 organic acid catabolic process 10/770 240/18722 0.52881105200352 0.726374937235179 KMO/ARG2/ABHD3/MTHFS/PPARD/IRS2/ACADVL/HIBADH/AIG1/CDO1 10 GO:0001956 positive regulation of neurotransmitter secretion 1/770 18/18722 0.530605011345786 0.726374937235179 KMO 1 GO:0002076 osteoblast development 1/770 18/18722 0.530605011345786 0.726374937235179 JUND 1 GO:0002283 neutrophil activation involved in immune response 1/770 18/18722 0.530605011345786 0.726374937235179 STXBP3 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/770 18/18722 0.530605011345786 0.726374937235179 CALR 1 GO:0003417 growth plate cartilage development 1/770 18/18722 0.530605011345786 0.726374937235179 ANXA6 1 GO:0006085 acetyl-CoA biosynthetic process 1/770 18/18722 0.530605011345786 0.726374937235179 ACSS1 1 GO:0006415 translational termination 1/770 18/18722 0.530605011345786 0.726374937235179 ETF1 1 GO:0006625 protein targeting to peroxisome 1/770 18/18722 0.530605011345786 0.726374937235179 ZFAND6 1 GO:0006991 response to sterol depletion 1/770 18/18722 0.530605011345786 0.726374937235179 INSIG1 1 GO:0007549 dosage compensation 1/770 18/18722 0.530605011345786 0.726374937235179 CDYL 1 GO:0009125 nucleoside monophosphate catabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 PNP 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 AK3 1 GO:0009404 toxin metabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 NFE2L2 1 GO:0015936 coenzyme A metabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 SLC25A16 1 GO:0019184 nonribosomal peptide biosynthetic process 1/770 18/18722 0.530605011345786 0.726374937235179 NFE2L2 1 GO:0019896 axonal transport of mitochondrion 1/770 18/18722 0.530605011345786 0.726374937235179 ARMCX3 1 GO:0021511 spinal cord patterning 1/770 18/18722 0.530605011345786 0.726374937235179 GLI3 1 GO:0030206 chondroitin sulfate biosynthetic process 1/770 18/18722 0.530605011345786 0.726374937235179 CHPF 1 GO:0030299 intestinal cholesterol absorption 1/770 18/18722 0.530605011345786 0.726374937235179 LDLR 1 GO:0030889 negative regulation of B cell proliferation 1/770 18/18722 0.530605011345786 0.726374937235179 TNFRSF21 1 GO:0031649 heat generation 1/770 18/18722 0.530605011345786 0.726374937235179 ARRDC3 1 GO:0032095 regulation of response to food 1/770 18/18722 0.530605011345786 0.726374937235179 NUCB2 1 GO:0032769 negative regulation of monooxygenase activity 1/770 18/18722 0.530605011345786 0.726374937235179 GLA 1 GO:0032785 negative regulation of DNA-templated transcription, elongation 1/770 18/18722 0.530605011345786 0.726374937235179 HEXIM1 1 GO:0033189 response to vitamin A 1/770 18/18722 0.530605011345786 0.726374937235179 PPARD 1 GO:0034433 steroid esterification 1/770 18/18722 0.530605011345786 0.726374937235179 ABCG1 1 GO:0034434 sterol esterification 1/770 18/18722 0.530605011345786 0.726374937235179 ABCG1 1 GO:0034435 cholesterol esterification 1/770 18/18722 0.530605011345786 0.726374937235179 ABCG1 1 GO:0035930 corticosteroid hormone secretion 1/770 18/18722 0.530605011345786 0.726374937235179 C1QTNF1 1 GO:0042693 muscle cell fate commitment 1/770 18/18722 0.530605011345786 0.726374937235179 TBX3 1 GO:0044247 cellular polysaccharide catabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 PPP1CB 1 GO:0045623 negative regulation of T-helper cell differentiation 1/770 18/18722 0.530605011345786 0.726374937235179 ANXA1 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/770 18/18722 0.530605011345786 0.726374937235179 SERPINB9 1 GO:0046040 IMP metabolic process 1/770 18/18722 0.530605011345786 0.726374937235179 PNP 1 GO:0046838 phosphorylated carbohydrate dephosphorylation 1/770 18/18722 0.530605011345786 0.726374937235179 SYNJ1 1 GO:0050665 hydrogen peroxide biosynthetic process 1/770 18/18722 0.530605011345786 0.726374937235179 SOD1 1 GO:0051447 negative regulation of meiotic cell cycle 1/770 18/18722 0.530605011345786 0.726374937235179 OVOL1 1 GO:0060008 Sertoli cell differentiation 1/770 18/18722 0.530605011345786 0.726374937235179 SDC1 1 GO:0060192 negative regulation of lipase activity 1/770 18/18722 0.530605011345786 0.726374937235179 ANXA1 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/770 18/18722 0.530605011345786 0.726374937235179 DAB2 1 GO:0060438 trachea development 1/770 18/18722 0.530605011345786 0.726374937235179 CTNNB1 1 GO:0060602 branch elongation of an epithelium 1/770 18/18722 0.530605011345786 0.726374937235179 RDH10 1 GO:0060716 labyrinthine layer blood vessel development 1/770 18/18722 0.530605011345786 0.726374937235179 HES1 1 GO:0060749 mammary gland alveolus development 1/770 18/18722 0.530605011345786 0.726374937235179 ID2 1 GO:0061377 mammary gland lobule development 1/770 18/18722 0.530605011345786 0.726374937235179 ID2 1 GO:0061484 hematopoietic stem cell homeostasis 1/770 18/18722 0.530605011345786 0.726374937235179 ADGRG1 1 GO:0071318 cellular response to ATP 1/770 18/18722 0.530605011345786 0.726374937235179 SOD1 1 GO:0071360 cellular response to exogenous dsRNA 1/770 18/18722 0.530605011345786 0.726374937235179 COLEC12 1 GO:0071786 endoplasmic reticulum tubular network organization 1/770 18/18722 0.530605011345786 0.726374937235179 TMEM33 1 GO:0072189 ureter development 1/770 18/18722 0.530605011345786 0.726374937235179 GATA3 1 GO:0072662 protein localization to peroxisome 1/770 18/18722 0.530605011345786 0.726374937235179 ZFAND6 1 GO:0072663 establishment of protein localization to peroxisome 1/770 18/18722 0.530605011345786 0.726374937235179 ZFAND6 1 GO:0080182 histone H3-K4 trimethylation 1/770 18/18722 0.530605011345786 0.726374937235179 TET2 1 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 1/770 18/18722 0.530605011345786 0.726374937235179 LGR4 1 GO:0150078 positive regulation of neuroinflammatory response 1/770 18/18722 0.530605011345786 0.726374937235179 NUPR1 1 GO:1900006 positive regulation of dendrite development 1/770 18/18722 0.530605011345786 0.726374937235179 TMEM106B 1 GO:1900225 regulation of NLRP3 inflammasome complex assembly 1/770 18/18722 0.530605011345786 0.726374937235179 DDX3X 1 GO:1900242 regulation of synaptic vesicle endocytosis 1/770 18/18722 0.530605011345786 0.726374937235179 AP2M1 1 GO:1900424 regulation of defense response to bacterium 1/770 18/18722 0.530605011345786 0.726374937235179 ARG2 1 GO:1902074 response to salt 1/770 18/18722 0.530605011345786 0.726374937235179 HSPA5 1 GO:1902170 cellular response to reactive nitrogen species 1/770 18/18722 0.530605011345786 0.726374937235179 CDK2 1 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1/770 18/18722 0.530605011345786 0.726374937235179 SEMA6A 1 GO:1903209 positive regulation of oxidative stress-induced cell death 1/770 18/18722 0.530605011345786 0.726374937235179 SOD1 1 GO:1905820 positive regulation of chromosome separation 1/770 18/18722 0.530605011345786 0.726374937235179 NUMA1 1 GO:0001504 neurotransmitter uptake 2/770 43/18722 0.53285601405104 0.72745795014146 SLC38A1/CLN8 2 GO:0002861 regulation of inflammatory response to antigenic stimulus 2/770 43/18722 0.53285601405104 0.72745795014146 FURIN/PSMB4 2 GO:0009268 response to pH 2/770 43/18722 0.53285601405104 0.72745795014146 SLC9A1/SERPINF1 2 GO:0021983 pituitary gland development 2/770 43/18722 0.53285601405104 0.72745795014146 HES1/GATA2 2 GO:0034661 ncRNA catabolic process 2/770 43/18722 0.53285601405104 0.72745795014146 DEDD2/XRN1 2 GO:0035794 positive regulation of mitochondrial membrane permeability 2/770 43/18722 0.53285601405104 0.72745795014146 SLC25A5/SLC9A1 2 GO:0036230 granulocyte activation 2/770 43/18722 0.53285601405104 0.72745795014146 PI4K2A/STXBP3 2 GO:0045981 positive regulation of nucleotide metabolic process 2/770 43/18722 0.53285601405104 0.72745795014146 APP/VCP 2 GO:1900544 positive regulation of purine nucleotide metabolic process 2/770 43/18722 0.53285601405104 0.72745795014146 APP/VCP 2 GO:1901381 positive regulation of potassium ion transmembrane transport 2/770 43/18722 0.53285601405104 0.72745795014146 KCNN4/AKAP9 2 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 3/770 68/18722 0.534092332900757 0.727823196218428 ANXA1/PRKCZ/GATA3 3 GO:0042267 natural killer cell mediated cytotoxicity 3/770 68/18722 0.534092332900757 0.727823196218428 ARL8B/SERPINB9/PLEKHM2 3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 3/770 68/18722 0.534092332900757 0.727823196218428 HES1/GHR/OSBP 3 GO:0042698 ovulation cycle 3/770 68/18722 0.534092332900757 0.727823196218428 EGFR/HSPA5/SERPINF1 3 GO:0046686 response to cadmium ion 3/770 68/18722 0.534092332900757 0.727823196218428 HMOX1/EGFR/SOD1 3 GO:1901607 alpha-amino acid biosynthetic process 3/770 68/18722 0.534092332900757 0.727823196218428 SERINC5/CLN3/ASNSD1 3 GO:0006813 potassium ion transport 10/770 241/18722 0.534145982053139 0.727823196218428 FXYD3/NEDD4L/KCNN4/CD63/AKAP9/KLHL24/SLC12A4/VPS4B/SLC9A1/KCNG1 10 GO:0007589 body fluid secretion 4/770 93/18722 0.535533999597367 0.728917213874264 EGFR/KCNN4/PRLR/CDO1 4 GO:0033108 mitochondrial respiratory chain complex assembly 4/770 93/18722 0.535533999597367 0.728917213874264 NDUFA6/COX17/NDUFB9/COX20 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 4/770 93/18722 0.535533999597367 0.728917213874264 EHD3/P2RY6/SLC9A1/UBQLN1 4 GO:1902807 negative regulation of cell cycle G1/S phase transition 4/770 93/18722 0.535533999597367 0.728917213874264 BCL2/MDM2/CDK2/GIGYF2 4 GO:1903313 positive regulation of mRNA metabolic process 5/770 118/18722 0.53707591393166 0.7308162968655 DHX36/GIGYF2/AGO2/PRDX6/HSPA8 5 GO:0034763 negative regulation of transmembrane transport 6/770 143/18722 0.538647042093581 0.732754084289466 SLC43A2/NEDD4L/IRS2/STXBP3/UBQLN1/COMMD1 6 GO:0000070 mitotic sister chromatid segregation 7/770 168/18722 0.540212684185778 0.733680252414385 RAB11A/CHMP2B/NUMA1/VPS4B/CHMP4B/EML4/CHMP2A 7 GO:0002443 leukocyte mediated immunity 18/770 440/18722 0.543692074955928 0.733680252414385 PRKCZ/TFRC/HMOX1/GATA3/CD55/ARL8B/DHX36/GATA2/SERPINB9/PDPK1/PLEKHM2/CD46/SUPT6H/PI4K2A/GNL1/STXBP3/SNAP23/HSPD1 18 GO:0002287 alpha-beta T cell activation involved in immune response 3/770 69/18722 0.544023640865383 0.733680252414385 ANXA1/PRKCZ/GATA3 3 GO:0002293 alpha-beta T cell differentiation involved in immune response 3/770 69/18722 0.544023640865383 0.733680252414385 ANXA1/PRKCZ/GATA3 3 GO:0003143 embryonic heart tube morphogenesis 3/770 69/18722 0.544023640865383 0.733680252414385 TBX3/HES1/MIB1 3 GO:0010611 regulation of cardiac muscle hypertrophy 3/770 69/18722 0.544023640865383 0.733680252414385 LMNA/SLC9A1/ERRFI1 3 GO:0033344 cholesterol efflux 3/770 69/18722 0.544023640865383 0.733680252414385 NFKBIA/ABCG1/LRP1 3 GO:0002690 positive regulation of leukocyte chemotaxis 4/770 94/18722 0.544031526217644 0.733680252414385 PGF/SERPINE1/AKIRIN1/CALR 4 GO:0032091 negative regulation of protein binding 4/770 94/18722 0.544031526217644 0.733680252414385 DAB2/LRPAP1/GOLGA2/CSNK1E 4 GO:1903035 negative regulation of response to wounding 4/770 94/18722 0.544031526217644 0.733680252414385 SERPINB2/SERPINE1/PHLDB2/C1QTNF1 4 GO:0006378 mRNA polyadenylation 2/770 44/18722 0.545336807797892 0.733680252414385 PAPOLA/APP 2 GO:0006775 fat-soluble vitamin metabolic process 2/770 44/18722 0.545336807797892 0.733680252414385 CYP11A1/PPARD 2 GO:0030521 androgen receptor signaling pathway 2/770 44/18722 0.545336807797892 0.733680252414385 DAB2/DNAJA1 2 GO:0042554 superoxide anion generation 2/770 44/18722 0.545336807797892 0.733680252414385 EGFR/SOD1 2 GO:0045124 regulation of bone resorption 2/770 44/18722 0.545336807797892 0.733680252414385 TFRC/EGFR 2 GO:0050999 regulation of nitric-oxide synthase activity 2/770 44/18722 0.545336807797892 0.733680252414385 EGFR/GLA 2 GO:0051150 regulation of smooth muscle cell differentiation 2/770 44/18722 0.545336807797892 0.733680252414385 PDCD4/FOXO4 2 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 2/770 44/18722 0.545336807797892 0.733680252414385 DDX3X/HSPA1B 2 GO:0007612 learning 6/770 144/18722 0.54550656943846 0.733680252414385 APP/ARF4/CLN3/CLN8/SYNJ1/EIF4A3 6 GO:0014065 phosphatidylinositol 3-kinase signaling 6/770 144/18722 0.54550656943846 0.733680252414385 PIK3C2A/EGFR/GATA3/ERBB3/PPARD/MYDGF 6 GO:0031644 regulation of nervous system process 6/770 144/18722 0.54550656943846 0.733680252414385 PRKCZ/APP/AKAP9/TNFRSF21/EIF4A3/SLC9A1 6 GO:0000075 cell cycle checkpoint signaling 7/770 169/18722 0.546543861135211 0.733680252414385 NABP1/FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/TAOK1 7 GO:0001696 gastric acid secretion 1/770 19/18722 0.54992890683679 0.733680252414385 SGK1 1 GO:0002281 macrophage activation involved in immune response 1/770 19/18722 0.54992890683679 0.733680252414385 DYSF 1 GO:0002396 MHC protein complex assembly 1/770 19/18722 0.54992890683679 0.733680252414385 CALR 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/770 19/18722 0.54992890683679 0.733680252414385 SERPINB9 1 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 1/770 19/18722 0.54992890683679 0.733680252414385 DHX36 1 GO:0006670 sphingosine metabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 PLPP3 1 GO:0006743 ubiquinone metabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 COQ10B 1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1/770 19/18722 0.54992890683679 0.733680252414385 MDM2 1 GO:0007530 sex determination 1/770 19/18722 0.54992890683679 0.733680252414385 MAP3K4 1 GO:0009081 branched-chain amino acid metabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 HIBADH 1 GO:0010002 cardioblast differentiation 1/770 19/18722 0.54992890683679 0.733680252414385 DHX36 1 GO:0010544 negative regulation of platelet activation 1/770 19/18722 0.54992890683679 0.733680252414385 C1QTNF1 1 GO:0010738 regulation of protein kinase A signaling 1/770 19/18722 0.54992890683679 0.733680252414385 MIF 1 GO:0010759 positive regulation of macrophage chemotaxis 1/770 19/18722 0.54992890683679 0.733680252414385 AKIRIN1 1 GO:0010829 negative regulation of glucose transmembrane transport 1/770 19/18722 0.54992890683679 0.733680252414385 STXBP3 1 GO:0019373 epoxygenase P450 pathway 1/770 19/18722 0.54992890683679 0.733680252414385 CYP2J2 1 GO:0031290 retinal ganglion cell axon guidance 1/770 19/18722 0.54992890683679 0.733680252414385 NRP1 1 GO:0032026 response to magnesium ion 1/770 19/18722 0.54992890683679 0.733680252414385 MDM2 1 GO:0033194 response to hydroperoxide 1/770 19/18722 0.54992890683679 0.733680252414385 GPX3 1 GO:0035728 response to hepatocyte growth factor 1/770 19/18722 0.54992890683679 0.733680252414385 NRP1 1 GO:0038092 nodal signaling pathway 1/770 19/18722 0.54992890683679 0.733680252414385 DACT2 1 GO:0042474 middle ear morphogenesis 1/770 19/18722 0.54992890683679 0.733680252414385 INSIG1 1 GO:0043652 engulfment of apoptotic cell 1/770 19/18722 0.54992890683679 0.733680252414385 RHOBTB1 1 GO:0044003 modulation by symbiont of host process 1/770 19/18722 0.54992890683679 0.733680252414385 SERPINB9 1 GO:0044546 NLRP3 inflammasome complex assembly 1/770 19/18722 0.54992890683679 0.733680252414385 DDX3X 1 GO:0045821 positive regulation of glycolytic process 1/770 19/18722 0.54992890683679 0.733680252414385 APP 1 GO:0046033 AMP metabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 AK3 1 GO:0046653 tetrahydrofolate metabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 MTHFS 1 GO:0046716 muscle cell cellular homeostasis 1/770 19/18722 0.54992890683679 0.733680252414385 SOD1 1 GO:0046782 regulation of viral transcription 1/770 19/18722 0.54992890683679 0.733680252414385 HEXIM1 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/770 19/18722 0.54992890683679 0.733680252414385 NR2F6 1 GO:0051546 keratinocyte migration 1/770 19/18722 0.54992890683679 0.733680252414385 PPARD 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/770 19/18722 0.54992890683679 0.733680252414385 CTNNB1 1 GO:0051957 positive regulation of amino acid transport 1/770 19/18722 0.54992890683679 0.733680252414385 KMO 1 GO:0062099 negative regulation of programmed necrotic cell death 1/770 19/18722 0.54992890683679 0.733680252414385 NUPR1 1 GO:0070233 negative regulation of T cell apoptotic process 1/770 19/18722 0.54992890683679 0.733680252414385 ARG2 1 GO:0070989 oxidative demethylation 1/770 19/18722 0.54992890683679 0.733680252414385 TET2 1 GO:0071545 inositol phosphate catabolic process 1/770 19/18722 0.54992890683679 0.733680252414385 SYNJ1 1 GO:0072074 kidney mesenchyme development 1/770 19/18722 0.54992890683679 0.733680252414385 BASP1 1 GO:0097501 stress response to metal ion 1/770 19/18722 0.54992890683679 0.733680252414385 HSPA5 1 GO:0098780 response to mitochondrial depolarisation 1/770 19/18722 0.54992890683679 0.733680252414385 SQSTM1 1 GO:1901659 glycosyl compound biosynthetic process 1/770 19/18722 0.54992890683679 0.733680252414385 PNP 1 GO:1901739 regulation of myoblast fusion 1/770 19/18722 0.54992890683679 0.733680252414385 GDF15 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/770 19/18722 0.54992890683679 0.733680252414385 CTNNB1 1 GO:1903975 regulation of glial cell migration 1/770 19/18722 0.54992890683679 0.733680252414385 LRP1 1 GO:1903978 regulation of microglial cell activation 1/770 19/18722 0.54992890683679 0.733680252414385 LDLR 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/770 19/18722 0.54992890683679 0.733680252414385 NRP1 1 GO:2000269 regulation of fibroblast apoptotic process 1/770 19/18722 0.54992890683679 0.733680252414385 BTG1 1 GO:2000738 positive regulation of stem cell differentiation 1/770 19/18722 0.54992890683679 0.733680252414385 DHX36 1 GO:2000831 regulation of steroid hormone secretion 1/770 19/18722 0.54992890683679 0.733680252414385 C1QTNF1 1 GO:0072655 establishment of protein localization to mitochondrion 5/770 120/18722 0.552112952439008 0.736252904015706 DDIT3/LEPROT/HSP90AA1/DNAJA1/HSPD1 5 GO:0002532 production of molecular mediator involved in inflammatory response 4/770 95/18722 0.552448245658183 0.736252904015706 PDCD4/SERPINE1/KPNA6/SNAP23 4 GO:0042982 amyloid precursor protein metabolic process 4/770 95/18722 0.552448245658183 0.736252904015706 BACE2/ABCG1/CLN3/AGO2 4 GO:0045666 positive regulation of neuron differentiation 4/770 95/18722 0.552448245658183 0.736252904015706 SPAG9/GATA2/CSNK1E/HMG20B 4 GO:0019439 aromatic compound catabolic process 19/770 467/18722 0.552900743740191 0.736658932100902 HMOX1/KMO/PNP/ETF1/ERN1/VCP/DHX36/RNASEH2C/DEDD2/MTHFS/LARP4B/TET2/RBM8A/MAOA/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2 19 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 3/770 70/18722 0.553830846319602 0.737503769965413 TFRC/SUPT6H/HSPD1 3 GO:0070830 bicellular tight junction assembly 3/770 70/18722 0.553830846319602 0.737503769965413 CLDN7/MPP7/CLDN4 3 GO:0003197 endocardial cushion development 2/770 45/18722 0.557582734113728 0.740718412180408 TBX3/MDM2 2 GO:0006110 regulation of glycolytic process 2/770 45/18722 0.557582734113728 0.740718412180408 NUPR1/APP 2 GO:0031670 cellular response to nutrient 2/770 45/18722 0.557582734113728 0.740718412180408 HMOX1/MDM2 2 GO:0032309 icosanoid secretion 2/770 45/18722 0.557582734113728 0.740718412180408 ANXA1/PNPLA8 2 GO:0035272 exocrine system development 2/770 45/18722 0.557582734113728 0.740718412180408 TGM2/NRP1 2 GO:0043631 RNA polyadenylation 2/770 45/18722 0.557582734113728 0.740718412180408 PAPOLA/APP 2 GO:0048599 oocyte development 2/770 45/18722 0.557582734113728 0.740718412180408 BCL2/CTNNB1 2 GO:0060421 positive regulation of heart growth 2/770 45/18722 0.557582734113728 0.740718412180408 BASP1/TGFBR3 2 GO:2000273 positive regulation of signaling receptor activity 2/770 45/18722 0.557582734113728 0.740718412180408 NCOA3/NRP1 2 GO:0071674 mononuclear cell migration 8/770 196/18722 0.559389970084899 0.74292116762608 ANXA1/GATA3/APP/SERPINE1/CD200/WASL/AKIRIN1/CALR 8 GO:0043500 muscle adaptation 5/770 121/18722 0.559541785334002 0.742924784524203 HMOX1/FBXO32/LMNA/SLC9A1/ERRFI1 5 GO:0071216 cellular response to biotic stimulus 10/770 246/18722 0.560491188914112 0.743778754742081 PDCD4/KMO/CEBPB/CD55/SERPINE1/DDIT3/NFKBIA/CD274/HSPA5/PPARD 10 GO:0003073 regulation of systemic arterial blood pressure 4/770 96/18722 0.56078201516476 0.743778754742081 HSD11B2/MME/ENPEP/ADM 4 GO:0035282 segmentation 4/770 96/18722 0.56078201516476 0.743778754742081 TBX3/BASP1/MIB1/NRP1 4 GO:0042632 cholesterol homeostasis 4/770 96/18722 0.56078201516476 0.743778754742081 MYLIP/ABCG1/LDLR/INSIG1 4 GO:0002228 natural killer cell mediated immunity 3/770 71/18722 0.563511349647119 0.743783236587298 ARL8B/SERPINB9/PLEKHM2 3 GO:0043550 regulation of lipid kinase activity 3/770 71/18722 0.563511349647119 0.743783236587298 NRBF2/VAV3/SOCS1 3 GO:0002221 pattern recognition receptor signaling pathway 7/770 172/18722 0.565311372897902 0.743783236587298 LGR4/NFKBIA/PDPK1/DDX3X/HSPA1B/COLEC12/HSPD1 7 GO:0015931 nucleobase-containing compound transport 9/770 222/18722 0.565355617269102 0.743783236587298 SLC19A1/SLC25A5/MVP/RBM8A/SUPT6H/IWS1/EIF4A3/SLC35B4/ALYREF 9 GO:0051208 sequestering of calcium ion 5/770 122/18722 0.566908625865657 0.743783236587298 DDIT3/ANXA6/P2RY6/PDPK1/CALR 5 GO:0072329 monocarboxylic acid catabolic process 5/770 122/18722 0.566908625865657 0.743783236587298 ABHD3/PPARD/IRS2/ACADVL/AIG1 5 GO:1990266 neutrophil migration 5/770 122/18722 0.566908625865657 0.743783236587298 CSF3R/VAV3/MPP1/BSG/PPIB 5 GO:0000272 polysaccharide catabolic process 1/770 20/18722 0.568458273341398 0.743783236587298 PPP1CB 1 GO:0001832 blastocyst growth 1/770 20/18722 0.568458273341398 0.743783236587298 SBDS 1 GO:0003159 morphogenesis of an endothelium 1/770 20/18722 0.568458273341398 0.743783236587298 CTNNB1 1 GO:0006346 DNA methylation-dependent heterochromatin assembly 1/770 20/18722 0.568458273341398 0.743783236587298 MBD3 1 GO:0006607 NLS-bearing protein import into nucleus 1/770 20/18722 0.568458273341398 0.743783236587298 KPNA6 1 GO:0009110 vitamin biosynthetic process 1/770 20/18722 0.568458273341398 0.743783236587298 PDXK 1 GO:0009713 catechol-containing compound biosynthetic process 1/770 20/18722 0.568458273341398 0.743783236587298 GATA3 1 GO:0010523 negative regulation of calcium ion transport into cytosol 1/770 20/18722 0.568458273341398 0.743783236587298 BCL2 1 GO:0014047 glutamate secretion 1/770 20/18722 0.568458273341398 0.743783236587298 KMO 1 GO:0016553 base conversion or substitution editing 1/770 20/18722 0.568458273341398 0.743783236587298 RBM47 1 GO:0031645 negative regulation of nervous system process 1/770 20/18722 0.568458273341398 0.743783236587298 TNFRSF21 1 GO:0032211 negative regulation of telomere maintenance via telomerase 1/770 20/18722 0.568458273341398 0.743783236587298 XRN1 1 GO:0032332 positive regulation of chondrocyte differentiation 1/770 20/18722 0.568458273341398 0.743783236587298 GLI3 1 GO:0032495 response to muramyl dipeptide 1/770 20/18722 0.568458273341398 0.743783236587298 NFKBIA 1 GO:0033005 positive regulation of mast cell activation 1/770 20/18722 0.568458273341398 0.743783236587298 GATA2 1 GO:0042359 vitamin D metabolic process 1/770 20/18722 0.568458273341398 0.743783236587298 CYP11A1 1 GO:0042423 catecholamine biosynthetic process 1/770 20/18722 0.568458273341398 0.743783236587298 GATA3 1 GO:0043691 reverse cholesterol transport 1/770 20/18722 0.568458273341398 0.743783236587298 ABCG1 1 GO:0045063 T-helper 1 cell differentiation 1/770 20/18722 0.568458273341398 0.743783236587298 ANXA1 1 GO:0046485 ether lipid metabolic process 1/770 20/18722 0.568458273341398 0.743783236587298 PAFAH1B1 1 GO:0048670 regulation of collateral sprouting 1/770 20/18722 0.568458273341398 0.743783236587298 LRP1 1 GO:0060252 positive regulation of glial cell proliferation 1/770 20/18722 0.568458273341398 0.743783236587298 EGFR 1 GO:0061154 endothelial tube morphogenesis 1/770 20/18722 0.568458273341398 0.743783236587298 CTNNB1 1 GO:0061318 renal filtration cell differentiation 1/770 20/18722 0.568458273341398 0.743783236587298 BASP1 1 GO:0070166 enamel mineralization 1/770 20/18722 0.568458273341398 0.743783236587298 SLC4A2 1 GO:0070932 histone H3 deacetylation 1/770 20/18722 0.568458273341398 0.743783236587298 HDAC5 1 GO:0071379 cellular response to prostaglandin stimulus 1/770 20/18722 0.568458273341398 0.743783236587298 P2RY6 1 GO:0071397 cellular response to cholesterol 1/770 20/18722 0.568458273341398 0.743783236587298 GRAMD1C 1 GO:0071625 vocalization behavior 1/770 20/18722 0.568458273341398 0.743783236587298 GLI3 1 GO:0071731 response to nitric oxide 1/770 20/18722 0.568458273341398 0.743783236587298 CDK2 1 GO:0072112 glomerular visceral epithelial cell differentiation 1/770 20/18722 0.568458273341398 0.743783236587298 BASP1 1 GO:0072567 chemokine (C-X-C motif) ligand 2 production 1/770 20/18722 0.568458273341398 0.743783236587298 LRP1 1 GO:0097503 sialylation 1/770 20/18722 0.568458273341398 0.743783236587298 ST3GAL4 1 GO:0140632 inflammasome complex assembly 1/770 20/18722 0.568458273341398 0.743783236587298 DDX3X 1 GO:1902004 positive regulation of amyloid-beta formation 1/770 20/18722 0.568458273341398 0.743783236587298 ABCG1 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/770 20/18722 0.568458273341398 0.743783236587298 HERPUD1 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/770 20/18722 0.568458273341398 0.743783236587298 NFE2L2 1 GO:1904263 positive regulation of TORC1 signaling 1/770 20/18722 0.568458273341398 0.743783236587298 SIK3 1 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 1/770 20/18722 0.568458273341398 0.743783236587298 LRP1 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/770 20/18722 0.568458273341398 0.743783236587298 PKIB 1 GO:0035335 peptidyl-tyrosine dephosphorylation 4/770 97/18722 0.56903083133293 0.743783236587298 PTPN21/DUSP5/PTP4A1/DUSP3 4 GO:0055092 sterol homeostasis 4/770 97/18722 0.56903083133293 0.743783236587298 MYLIP/ABCG1/LDLR/INSIG1 4 GO:0070167 regulation of biomineral tissue development 4/770 97/18722 0.56903083133293 0.743783236587298 CEBPB/TFAP2A/PHOSPHO1/SLC4A2 4 GO:0006383 transcription by RNA polymerase III 2/770 46/18722 0.569591978891657 0.743783236587298 DHX36/CEBPA 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/770 46/18722 0.569591978891657 0.743783236587298 TENM3/CD164 2 GO:0010830 regulation of myotube differentiation 2/770 46/18722 0.569591978891657 0.743783236587298 BCL2/HDAC5 2 GO:0035094 response to nicotine 2/770 46/18722 0.569591978891657 0.743783236587298 HMOX1/BCL2 2 GO:0043616 keratinocyte proliferation 2/770 46/18722 0.569591978891657 0.743783236587298 PPARD/IRF6 2 GO:0050919 negative chemotaxis 2/770 46/18722 0.569591978891657 0.743783236587298 SEMA6A/SEMA7A 2 GO:0055010 ventricular cardiac muscle tissue morphogenesis 2/770 46/18722 0.569591978891657 0.743783236587298 DSP/TGFBR3 2 GO:0071827 plasma lipoprotein particle organization 2/770 46/18722 0.569591978891657 0.743783236587298 ABCG1/ARF1 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/770 46/18722 0.569591978891657 0.743783236587298 ARG2/IRS2 2 GO:0050864 regulation of B cell activation 8/770 198/18722 0.57098311140062 0.745404465315507 TFRC/VAV3/BCL2/ID2/TNFRSF21/IRS2/SUPT6H/MIF 8 GO:0019221 cytokine-mediated signaling pathway 19/770 472/18722 0.571880413449511 0.746380330073053 CSF3R/GREM2/NFKBIA/GHR/KRT18/SOCS1/KRT8/CEBPA/P4HB/IL10RB/LIFR/HSPA1B/RPS6KA5/PRLR/TBK1/CSF2RA/PAFAH1B1/COMMD7/ACTN4 19 GO:2001056 positive regulation of cysteine-type endopeptidase activity 6/770 148/18722 0.572476111058221 0.746962152763319 PMAIP1/VCP/DDX3X/PDCD6/HSPE1/HSPD1 6 GO:0014743 regulation of muscle hypertrophy 3/770 72/18722 0.573062809084085 0.747140758154368 LMNA/SLC9A1/ERRFI1 3 GO:0033627 cell adhesion mediated by integrin 3/770 72/18722 0.573062809084085 0.747140758154368 SERPINE1/PLPP3/ITGB4 3 GO:0051057 positive regulation of small GTPase mediated signal transduction 3/770 72/18722 0.573062809084085 0.747140758154368 TGM2/ADGRG1/LRRC59 3 GO:0030168 platelet activation 5/770 123/18722 0.574211927901199 0.74844311711527 HSPB1/VAV3/GNAS/C1QTNF1/STXBP3 5 GO:1901988 negative regulation of cell cycle phase transition 10/770 249/18722 0.576008304987967 0.750588227969414 NABP1/OVOL1/BCL2/FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/USP47/TAOK1 10 GO:0043502 regulation of muscle adaptation 4/770 98/18722 0.577192827032427 0.751714578979573 FBXO32/LMNA/SLC9A1/ERRFI1 4 GO:0001774 microglial cell activation 2/770 47/18722 0.581363273663586 0.751714578979573 APP/LDLR 2 GO:0007595 lactation 2/770 47/18722 0.581363273663586 0.751714578979573 PRLR/CDO1 2 GO:0031641 regulation of myelination 2/770 47/18722 0.581363273663586 0.751714578979573 TNFRSF21/CTNNB1 2 GO:0043114 regulation of vascular permeability 2/770 47/18722 0.581363273663586 0.751714578979573 ADM/FERMT2 2 GO:0045332 phospholipid translocation 2/770 47/18722 0.581363273663586 0.751714578979573 ATP10D/KCNN4 2 GO:0045601 regulation of endothelial cell differentiation 2/770 47/18722 0.581363273663586 0.751714578979573 BTG1/CTNNB1 2 GO:0045646 regulation of erythrocyte differentiation 2/770 47/18722 0.581363273663586 0.751714578979573 GATA2/HSPA1B 2 GO:0045747 positive regulation of Notch signaling pathway 2/770 47/18722 0.581363273663586 0.751714578979573 HES1/AAK1 2 GO:0045911 positive regulation of DNA recombination 2/770 47/18722 0.581363273663586 0.751714578979573 TFRC/UBE2B 2 GO:0048512 circadian behavior 2/770 47/18722 0.581363273663586 0.751714578979573 ID2/GPR157 2 GO:0061001 regulation of dendritic spine morphogenesis 2/770 47/18722 0.581363273663586 0.751714578979573 DHX36/PAFAH1B1 2 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 2/770 47/18722 0.581363273663586 0.751714578979573 HMOX1/GATA2 2 GO:0009132 nucleoside diphosphate metabolic process 5/770 124/18722 0.581450227911786 0.751714578979573 NUPR1/APP/AK3/MPP1/BPGM 5 GO:0097237 cellular response to toxic substance 5/770 124/18722 0.581450227911786 0.751714578979573 GPX3/MGST3/PRDX6/SOD1/NFE2L2 5 GO:0002637 regulation of immunoglobulin production 3/770 73/18722 0.582483130750888 0.751714578979573 TFRC/DNAJB9/SUPT6H 3 GO:0007631 feeding behavior 4/770 99/18722 0.585266268252448 0.751714578979573 GDF15/NPB/APP/GIGYF2 4 GO:0110149 regulation of biomineralization 4/770 99/18722 0.585266268252448 0.751714578979573 CEBPB/TFAP2A/PHOSPHO1/SLC4A2 4 GO:0030198 extracellular matrix organization 12/770 301/18722 0.585482925212636 0.751714578979573 FBLN1/SPINT1/APP/SMOC1/ELF3/FURIN/PHLDB2/VWA1/SPINT2/LRP1/DNAJB6/ADAMTS6 12 GO:0003091 renal water homeostasis 1/770 21/18722 0.586225738293121 0.751714578979573 AKR1B1 1 GO:0006067 ethanol metabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 ACSS1 1 GO:0007063 regulation of sister chromatid cohesion 1/770 21/18722 0.586225738293121 0.751714578979573 CTNNB1 1 GO:0007252 I-kappaB phosphorylation 1/770 21/18722 0.586225738293121 0.751714578979573 ERC1 1 GO:0007617 mating behavior 1/770 21/18722 0.586225738293121 0.751714578979573 APP 1 GO:0009067 aspartate family amino acid biosynthetic process 1/770 21/18722 0.586225738293121 0.751714578979573 ASNSD1 1 GO:0009070 serine family amino acid biosynthetic process 1/770 21/18722 0.586225738293121 0.751714578979573 SERINC5 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/770 21/18722 0.586225738293121 0.751714578979573 MYLIP 1 GO:0019370 leukotriene biosynthetic process 1/770 21/18722 0.586225738293121 0.751714578979573 MGST3 1 GO:0031145 anaphase-promoting complex-dependent catabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 CDK2 1 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 1/770 21/18722 0.586225738293121 0.751714578979573 SNAP23 1 GO:0031998 regulation of fatty acid beta-oxidation 1/770 21/18722 0.586225738293121 0.751714578979573 IRS2 1 GO:0033762 response to glucagon 1/770 21/18722 0.586225738293121 0.751714578979573 CDO1 1 GO:0034035 purine ribonucleoside bisphosphate metabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 SLC26A2 1 GO:0035020 regulation of Rac protein signal transduction 1/770 21/18722 0.586225738293121 0.751714578979573 ARHGAP24 1 GO:0035330 regulation of hippo signaling 1/770 21/18722 0.586225738293121 0.751714578979573 DLG5 1 GO:0035455 response to interferon-alpha 1/770 21/18722 0.586225738293121 0.751714578979573 GATA3 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/770 21/18722 0.586225738293121 0.751714578979573 EGFR 1 GO:0042454 ribonucleoside catabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 PNP 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/770 21/18722 0.586225738293121 0.751714578979573 CTSL 1 GO:0044241 lipid digestion 1/770 21/18722 0.586225738293121 0.751714578979573 LDLR 1 GO:0046128 purine ribonucleoside metabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 PNP 1 GO:0046519 sphingoid metabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 PLPP3 1 GO:0046599 regulation of centriole replication 1/770 21/18722 0.586225738293121 0.751714578979573 VPS4B 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/770 21/18722 0.586225738293121 0.751714578979573 CD55 1 GO:0046885 regulation of hormone biosynthetic process 1/770 21/18722 0.586225738293121 0.751714578979573 ADM 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/770 21/18722 0.586225738293121 0.751714578979573 RHEB 1 GO:0048745 smooth muscle tissue development 1/770 21/18722 0.586225738293121 0.751714578979573 ZFAND5 1 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 1/770 21/18722 0.586225738293121 0.751714578979573 SLC26A2 1 GO:0072311 glomerular epithelial cell differentiation 1/770 21/18722 0.586225738293121 0.751714578979573 BASP1 1 GO:0090026 positive regulation of monocyte chemotaxis 1/770 21/18722 0.586225738293121 0.751714578979573 SERPINE1 1 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 1/770 21/18722 0.586225738293121 0.751714578979573 LGR4 1 GO:0098719 sodium ion import across plasma membrane 1/770 21/18722 0.586225738293121 0.751714578979573 SLC9A1 1 GO:0098856 intestinal lipid absorption 1/770 21/18722 0.586225738293121 0.751714578979573 LDLR 1 GO:0099500 vesicle fusion to plasma membrane 1/770 21/18722 0.586225738293121 0.751714578979573 SNAP23 1 GO:0150146 cell junction disassembly 1/770 21/18722 0.586225738293121 0.751714578979573 DUSP3 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/770 21/18722 0.586225738293121 0.751714578979573 SLC25A5 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/770 21/18722 0.586225738293121 0.751714578979573 KCNG1 1 GO:1902473 regulation of protein localization to synapse 1/770 21/18722 0.586225738293121 0.751714578979573 PRKCZ 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/770 21/18722 0.586225738293121 0.751714578979573 HSPD1 1 GO:1905209 positive regulation of cardiocyte differentiation 1/770 21/18722 0.586225738293121 0.751714578979573 DHX36 1 GO:2000774 positive regulation of cellular senescence 1/770 21/18722 0.586225738293121 0.751714578979573 ARG2 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/770 21/18722 0.586225738293121 0.751714578979573 AKIRIN1 1 GO:0044270 cellular nitrogen compound catabolic process 18/770 451/18722 0.586448382343464 0.751806609008871 HMOX1/KMO/PNP/ETF1/ERN1/VCP/DHX36/RNASEH2C/DEDD2/MTHFS/LARP4B/TET2/RBM8A/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2 18 GO:0055007 cardiac muscle cell differentiation 5/770 125/18722 0.588622143757133 0.75420523073844 TBX3/NEBL/LMNA/CALR/SLC9A1 5 GO:0070585 protein localization to mitochondrion 5/770 125/18722 0.588622143757133 0.75420523073844 DDIT3/LEPROT/HSP90AA1/DNAJA1/HSPD1 5 GO:0043062 extracellular structure organization 12/770 302/18722 0.59012143173009 0.755931900851166 FBLN1/SPINT1/APP/SMOC1/ELF3/FURIN/PHLDB2/VWA1/SPINT2/LRP1/DNAJB6/ADAMTS6 12 GO:0002437 inflammatory response to antigenic stimulus 3/770 74/18722 0.591770458787463 0.756956197785722 GATA3/FURIN/PSMB4 3 GO:0006635 fatty acid beta-oxidation 3/770 74/18722 0.591770458787463 0.756956197785722 PPARD/IRS2/ACADVL 3 GO:0006801 superoxide metabolic process 3/770 74/18722 0.591770458787463 0.756956197785722 EGFR/SOD1/NFE2L2 3 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 3/770 74/18722 0.591770458787463 0.756956197785722 DAB2/CALR/UBA5 3 GO:0030902 hindbrain development 6/770 151/18722 0.592175401618938 0.756956197785722 HES1/BCL2/GATA2/OPHN1/HSPA5/CTNNB1 6 GO:0071826 ribonucleoprotein complex subunit organization 9/770 227/18722 0.592304729188532 0.756956197785722 EIF5/VCP/DDX28/EIF2S2/SRSF5/EIF4H/AGO2/HSP90AA1/EIF3J 9 GO:0006111 regulation of gluconeogenesis 2/770 48/18722 0.592895853894777 0.756956197785722 DDB1/SLC35B4 2 GO:0042908 xenobiotic transport 2/770 48/18722 0.592895853894777 0.756956197785722 SLC2A1/SLC7A5 2 GO:0045912 negative regulation of carbohydrate metabolic process 2/770 48/18722 0.592895853894777 0.756956197785722 NUPR1/AP2A1 2 GO:0061647 histone H3-K9 modification 2/770 48/18722 0.592895853894777 0.756956197785722 GATA3/LMNA 2 GO:1903053 regulation of extracellular matrix organization 2/770 48/18722 0.592895853894777 0.756956197785722 PHLDB2/LRP1 2 GO:1905710 positive regulation of membrane permeability 2/770 48/18722 0.592895853894777 0.756956197785722 SLC25A5/SLC9A1 2 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2/770 48/18722 0.592895853894777 0.756956197785722 RYBP/UBXN1 2 GO:0006641 triglyceride metabolic process 4/770 100/18722 0.593249550879399 0.75721375820493 ABHD5/LDLR/PNPLA2/INSIG1 4 GO:0000819 sister chromatid segregation 8/770 202/18722 0.593747005581025 0.757654629656914 RAB11A/CHMP2B/NUMA1/CTNNB1/VPS4B/CHMP4B/EML4/CHMP2A 8 GO:0045229 external encapsulating structure organization 12/770 304/18722 0.599329706435138 0.7623894349852 FBLN1/SPINT1/APP/SMOC1/ELF3/FURIN/PHLDB2/VWA1/SPINT2/LRP1/DNAJB6/ADAMTS6 12 GO:0006094 gluconeogenesis 3/770 75/18722 0.600923165611868 0.7623894349852 ATF3/DDB1/SLC35B4 3 GO:0034121 regulation of toll-like receptor signaling pathway 3/770 75/18722 0.600923165611868 0.7623894349852 LGR4/PDPK1/DDX3X 3 GO:0006476 protein deacetylation 4/770 101/18722 0.601141197418015 0.7623894349852 SIN3B/HOPX/HDAC5/BEX4 4 GO:0048015 phosphatidylinositol-mediated signaling 7/770 178/18722 0.601733441200048 0.7623894349852 PIK3C2A/EGFR/GATA3/EZR/ERBB3/PPARD/MYDGF 7 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 1/770 22/18722 0.603262590948824 0.7623894349852 ADM 1 GO:0006662 glycerol ether metabolic process 1/770 22/18722 0.603262590948824 0.7623894349852 PAFAH1B1 1 GO:0006907 pinocytosis 1/770 22/18722 0.603262590948824 0.7623894349852 CLN3 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/770 22/18722 0.603262590948824 0.7623894349852 SPESP1 1 GO:0007398 ectoderm development 1/770 22/18722 0.603262590948824 0.7623894349852 CTNNB1 1 GO:0010866 regulation of triglyceride biosynthetic process 1/770 22/18722 0.603262590948824 0.7623894349852 LDLR 1 GO:0014821 phasic smooth muscle contraction 1/770 22/18722 0.603262590948824 0.7623894349852 TBX3 1 GO:0019400 alditol metabolic process 1/770 22/18722 0.603262590948824 0.7623894349852 AKR1B1 1 GO:0021854 hypothalamus development 1/770 22/18722 0.603262590948824 0.7623894349852 NRP1 1 GO:0021904 dorsal/ventral neural tube patterning 1/770 22/18722 0.603262590948824 0.7623894349852 GLI3 1 GO:0022401 negative adaptation of signaling pathway 1/770 22/18722 0.603262590948824 0.7623894349852 ADM 1 GO:0032098 regulation of appetite 1/770 22/18722 0.603262590948824 0.7623894349852 NUCB2 1 GO:0034755 iron ion transmembrane transport 1/770 22/18722 0.603262590948824 0.7623894349852 SLC40A1 1 GO:0035024 negative regulation of Rho protein signal transduction 1/770 22/18722 0.603262590948824 0.7623894349852 KANK1 1 GO:0035089 establishment of apical/basal cell polarity 1/770 22/18722 0.603262590948824 0.7623894349852 OPHN1 1 GO:0035357 peroxisome proliferator activated receptor signaling pathway 1/770 22/18722 0.603262590948824 0.7623894349852 ACTN4 1 GO:0042430 indole-containing compound metabolic process 1/770 22/18722 0.603262590948824 0.7623894349852 KMO 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/770 22/18722 0.603262590948824 0.7623894349852 ANXA1 1 GO:0043574 peroxisomal transport 1/770 22/18722 0.603262590948824 0.7623894349852 ZFAND6 1 GO:0044346 fibroblast apoptotic process 1/770 22/18722 0.603262590948824 0.7623894349852 BTG1 1 GO:0051220 cytoplasmic sequestering of protein 1/770 22/18722 0.603262590948824 0.7623894349852 NFKBIA 1 GO:0060343 trabecula formation 1/770 22/18722 0.603262590948824 0.7623894349852 TGFBR3 1 GO:0060965 negative regulation of gene silencing by miRNA 1/770 22/18722 0.603262590948824 0.7623894349852 NEAT1 1 GO:0071359 cellular response to dsRNA 1/770 22/18722 0.603262590948824 0.7623894349852 COLEC12 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/770 22/18722 0.603262590948824 0.7623894349852 LDLR 1 GO:0071467 cellular response to pH 1/770 22/18722 0.603262590948824 0.7623894349852 SLC9A1 1 GO:0072574 hepatocyte proliferation 1/770 22/18722 0.603262590948824 0.7623894349852 CEBPB 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/770 22/18722 0.603262590948824 0.7623894349852 CEBPB 1 GO:0097164 ammonium ion metabolic process 1/770 22/18722 0.603262590948824 0.7623894349852 SLC44A1 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/770 22/18722 0.603262590948824 0.7623894349852 NUPR1 1 GO:1901032 negative regulation of response to reactive oxygen species 1/770 22/18722 0.603262590948824 0.7623894349852 NFE2L2 1 GO:0002762 negative regulation of myeloid leukocyte differentiation 2/770 49/18722 0.604189419778558 0.7623894349852 GATA2/CTNNB1 2 GO:0007622 rhythmic behavior 2/770 49/18722 0.604189419778558 0.7623894349852 ID2/GPR157 2 GO:0009066 aspartate family amino acid metabolic process 2/770 49/18722 0.604189419778558 0.7623894349852 SMS/ASNSD1 2 GO:0009994 oocyte differentiation 2/770 49/18722 0.604189419778558 0.7623894349852 BCL2/CTNNB1 2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 2/770 49/18722 0.604189419778558 0.7623894349852 GDF15/DAB2 2 GO:0018198 peptidyl-cysteine modification 2/770 49/18722 0.604189419778558 0.7623894349852 ZDHHC3/ZDHHC20 2 GO:0021695 cerebellar cortex development 2/770 49/18722 0.604189419778558 0.7623894349852 OPHN1/HSPA5 2 GO:0086009 membrane repolarization 2/770 49/18722 0.604189419778558 0.7623894349852 NEDD4L/AKAP9 2 GO:0045833 negative regulation of lipid metabolic process 4/770 102/18722 0.608939853666144 0.767701498933699 ACADVL/ORMDL1/INSIG1/SOD1 4 GO:0062014 negative regulation of small molecule metabolic process 4/770 102/18722 0.608939853666144 0.767701498933699 NUPR1/ACADVL/INSIG1/SOD1 4 GO:1904063 negative regulation of cation transmembrane transport 4/770 102/18722 0.608939853666144 0.767701498933699 SLC43A2/NEDD4L/UBQLN1/COMMD1 4 GO:0032612 interleukin-1 production 5/770 128/18722 0.609726958535083 0.767701498933699 ANXA1/HSPB1/ARG2/APP/ERRFI1 5 GO:0032652 regulation of interleukin-1 production 5/770 128/18722 0.609726958535083 0.767701498933699 ANXA1/HSPB1/ARG2/APP/ERRFI1 5 GO:0008652 cellular amino acid biosynthetic process 3/770 76/18722 0.609939842319589 0.767701498933699 SERINC5/CLN3/ASNSD1 3 GO:0009123 nucleoside monophosphate metabolic process 3/770 76/18722 0.609939842319589 0.767701498933699 AK3/PNP/MPP1 3 GO:0014855 striated muscle cell proliferation 3/770 76/18722 0.609939842319589 0.767701498933699 PPARD/AKIRIN1/TGFBR3 3 GO:0021536 diencephalon development 3/770 76/18722 0.609939842319589 0.767701498933699 HES1/GATA2/NRP1 3 GO:0071426 ribonucleoprotein complex export from nucleus 3/770 76/18722 0.609939842319589 0.767701498933699 SUPT6H/IWS1/ALYREF 3 GO:0007018 microtubule-based movement 15/770 382/18722 0.610278543252735 0.767933833593025 PRKCZ/HSPB1/UBE2B/APP/ARL8B/CCSAP/CLN3/RAB1A/RAB21/ARMCX3/KIF21A/PAFAH1B1/DNAJA1/HSPA8/SOD1 15 GO:0007605 sensory perception of sound 6/770 154/18722 0.611388330667681 0.769136089804861 TFAP2A/DDIT3/SLC52A3/MYO6/NDUFB9/SOD1 6 GO:0002639 positive regulation of immunoglobulin production 2/770 50/18722 0.615244099396529 0.76994040044561 TFRC/DNAJB9 2 GO:0038202 TORC1 signaling 2/770 50/18722 0.615244099396529 0.76994040044561 RRAGC/SIK3 2 GO:0043268 positive regulation of potassium ion transport 2/770 50/18722 0.615244099396529 0.76994040044561 KCNN4/AKAP9 2 GO:0046460 neutral lipid biosynthetic process 2/770 50/18722 0.615244099396529 0.76994040044561 LDLR/PNPLA2 2 GO:0046463 acylglycerol biosynthetic process 2/770 50/18722 0.615244099396529 0.76994040044561 LDLR/PNPLA2 2 GO:1903747 regulation of establishment of protein localization to mitochondrion 2/770 50/18722 0.615244099396529 0.76994040044561 LEPROT/DNAJA1 2 GO:0045639 positive regulation of myeloid cell differentiation 4/770 103/18722 0.616644285352891 0.76994040044561 SCIN/GATA2/ID2/HSPA1B 4 GO:0046434 organophosphate catabolic process 6/770 155/18722 0.617679973032957 0.76994040044561 PNP/VCP/PNPLA8/LDLR/SYNJ1/PRDX6 6 GO:0000380 alternative mRNA splicing, via spliceosome 3/770 77/18722 0.618819289238976 0.76994040044561 MBNL3/SAP18/RBM8A 3 GO:0002200 somatic diversification of immune receptors 3/770 77/18722 0.618819289238976 0.76994040044561 TFRC/SUPT6H/HSPD1 3 GO:0071166 ribonucleoprotein complex localization 3/770 77/18722 0.618819289238976 0.76994040044561 SUPT6H/IWS1/ALYREF 3 GO:0140056 organelle localization by membrane tethering 3/770 77/18722 0.618819289238976 0.76994040044561 CLN3/STX5/STXBP3 3 GO:0032640 tumor necrosis factor production 7/770 181/18722 0.619337322106849 0.76994040044561 HSPB1/ARG2/APP/DDT/MIF/ERRFI1/HSPD1 7 GO:0032680 regulation of tumor necrosis factor production 7/770 181/18722 0.619337322106849 0.76994040044561 HSPB1/ARG2/APP/DDT/MIF/ERRFI1/HSPD1 7 GO:0001759 organ induction 1/770 23/18722 0.619598837203872 0.76994040044561 CTNNB1 1 GO:0003283 atrial septum development 1/770 23/18722 0.619598837203872 0.76994040044561 MDM2 1 GO:0006541 glutamine metabolic process 1/770 23/18722 0.619598837203872 0.76994040044561 ASNSD1 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/770 23/18722 0.619598837203872 0.76994040044561 PNP 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/770 23/18722 0.619598837203872 0.76994040044561 LRP1 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/770 23/18722 0.619598837203872 0.76994040044561 IWS1 1 GO:0021544 subpallium development 1/770 23/18722 0.619598837203872 0.76994040044561 GLI3 1 GO:0021884 forebrain neuron development 1/770 23/18722 0.619598837203872 0.76994040044561 NRP1 1 GO:0023058 adaptation of signaling pathway 1/770 23/18722 0.619598837203872 0.76994040044561 ADM 1 GO:0031338 regulation of vesicle fusion 1/770 23/18722 0.619598837203872 0.76994040044561 ANXA1 1 GO:0032740 positive regulation of interleukin-17 production 1/770 23/18722 0.619598837203872 0.76994040044561 SLC7A5 1 GO:0033081 regulation of T cell differentiation in thymus 1/770 23/18722 0.619598837203872 0.76994040044561 SOD1 1 GO:0034105 positive regulation of tissue remodeling 1/770 23/18722 0.619598837203872 0.76994040044561 TMBIM1 1 GO:0035640 exploration behavior 1/770 23/18722 0.619598837203872 0.76994040044561 EIF4A3 1 GO:0035812 renal sodium excretion 1/770 23/18722 0.619598837203872 0.76994040044561 MLLT6 1 GO:0035929 steroid hormone secretion 1/770 23/18722 0.619598837203872 0.76994040044561 C1QTNF1 1 GO:0035988 chondrocyte proliferation 1/770 23/18722 0.619598837203872 0.76994040044561 GOLGB1 1 GO:0040019 positive regulation of embryonic development 1/770 23/18722 0.619598837203872 0.76994040044561 PAFAH1B1 1 GO:0043931 ossification involved in bone maturation 1/770 23/18722 0.619598837203872 0.76994040044561 PHOSPHO1 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/770 23/18722 0.619598837203872 0.76994040044561 ANXA1 1 GO:0045932 negative regulation of muscle contraction 1/770 23/18722 0.619598837203872 0.76994040044561 SOD1 1 GO:0045980 negative regulation of nucleotide metabolic process 1/770 23/18722 0.619598837203872 0.76994040044561 NUPR1 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/770 23/18722 0.619598837203872 0.76994040044561 CHPF 1 GO:0050765 negative regulation of phagocytosis 1/770 23/18722 0.619598837203872 0.76994040044561 DYSF 1 GO:0051457 maintenance of protein location in nucleus 1/770 23/18722 0.619598837203872 0.76994040044561 SKP1 1 GO:0051590 positive regulation of neurotransmitter transport 1/770 23/18722 0.619598837203872 0.76994040044561 KMO 1 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 1/770 23/18722 0.619598837203872 0.76994040044561 AKAP9 1 GO:0060353 regulation of cell adhesion molecule production 1/770 23/18722 0.619598837203872 0.76994040044561 COLEC12 1 GO:0060384 innervation 1/770 23/18722 0.619598837203872 0.76994040044561 NRP1 1 GO:0060547 negative regulation of necrotic cell death 1/770 23/18722 0.619598837203872 0.76994040044561 NUPR1 1 GO:0060575 intestinal epithelial cell differentiation 1/770 23/18722 0.619598837203872 0.76994040044561 YIPF6 1 GO:0071218 cellular response to misfolded protein 1/770 23/18722 0.619598837203872 0.76994040044561 VCP 1 GO:0072576 liver morphogenesis 1/770 23/18722 0.619598837203872 0.76994040044561 CEBPB 1 GO:1904666 regulation of ubiquitin protein ligase activity 1/770 23/18722 0.619598837203872 0.76994040044561 SKP1 1 GO:2001169 regulation of ATP biosynthetic process 1/770 23/18722 0.619598837203872 0.76994040044561 VCP 1 GO:0031348 negative regulation of defense response 10/770 258/18722 0.621054143237382 0.771556418786306 GATA3/ARG2/CD200/FURIN/SERPINB9/PPARD/LDLR/PSMB4/SERPINF1/SOD1 10 GO:0006282 regulation of DNA repair 5/770 130/18722 0.623443117437896 0.774331269739042 EGFR/OTUB2/SPIRE2/UBR5/PPP4R2 5 GO:0006520 cellular amino acid metabolic process 11/770 284/18722 0.623706839973821 0.774465782105545 KMO/ARG2/SERINC5/RIMKLB/CLN3/MTHFS/SMS/HIBADH/CDO1/ASNSD1/AZIN1 11 GO:0022600 digestive system process 4/770 104/18722 0.624253374749238 0.774951312001857 SGK1/EZR/KCNN4/LDLR 4 GO:0048017 inositol lipid-mediated signaling 7/770 182/18722 0.625109907444796 0.775821337184911 PIK3C2A/EGFR/GATA3/EZR/ERBB3/PPARD/MYDGF 7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 2/770 51/18722 0.626060414116384 0.77584159252473 NDUFA6/NDUFB9 2 GO:0014009 glial cell proliferation 2/770 51/18722 0.626060414116384 0.77584159252473 EGFR/HES1 2 GO:0048013 ephrin receptor signaling pathway 2/770 51/18722 0.626060414116384 0.77584159252473 RASA1/EPHB4 2 GO:0050982 detection of mechanical stimulus 2/770 51/18722 0.626060414116384 0.77584159252473 JUP/CTNNB1 2 GO:0065002 intracellular protein transmembrane transport 2/770 51/18722 0.626060414116384 0.77584159252473 HSPA5/HSPD1 2 GO:0071622 regulation of granulocyte chemotaxis 2/770 51/18722 0.626060414116384 0.77584159252473 MPP1/AKIRIN1 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 3/770 78/18722 0.627560506656271 0.777507211503779 ARG2/CD274/ERRFI1 3 GO:0040029 regulation of gene expression, epigenetic 4/770 105/18722 0.631766117259667 0.780452856394683 CDYL/MBD3/HDAC5/SERTAD1 4 GO:0062207 regulation of pattern recognition receptor signaling pathway 4/770 105/18722 0.631766117259667 0.780452856394683 LGR4/PDPK1/DDX3X/HSPA1B 4 GO:0071222 cellular response to lipopolysaccharide 8/770 209/18722 0.632098944863015 0.780452856394683 PDCD4/KMO/CEBPB/CD55/SERPINE1/NFKBIA/CD274/PPARD 8 GO:0001702 gastrulation with mouth forming second 1/770 24/18722 0.635263252164727 0.780452856394683 CTNNB1 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/770 24/18722 0.635263252164727 0.780452856394683 SERPINB9 1 GO:0002021 response to dietary excess 1/770 24/18722 0.635263252164727 0.780452856394683 GDF15 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/770 24/18722 0.635263252164727 0.780452856394683 GATA3 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/770 24/18722 0.635263252164727 0.780452856394683 HSPD1 1 GO:0003148 outflow tract septum morphogenesis 1/770 24/18722 0.635263252164727 0.780452856394683 NRP1 1 GO:0003181 atrioventricular valve morphogenesis 1/770 24/18722 0.635263252164727 0.780452856394683 MDM2 1 GO:0016048 detection of temperature stimulus 1/770 24/18722 0.635263252164727 0.780452856394683 NR2F6 1 GO:0021697 cerebellar cortex formation 1/770 24/18722 0.635263252164727 0.780452856394683 OPHN1 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/770 24/18722 0.635263252164727 0.780452856394683 VCP 1 GO:0030878 thyroid gland development 1/770 24/18722 0.635263252164727 0.780452856394683 CGA 1 GO:0031639 plasminogen activation 1/770 24/18722 0.635263252164727 0.780452856394683 SERPINE1 1 GO:0038095 Fc-epsilon receptor signaling pathway 1/770 24/18722 0.635263252164727 0.780452856394683 VAV3 1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1/770 24/18722 0.635263252164727 0.780452856394683 GATA3 1 GO:0043302 positive regulation of leukocyte degranulation 1/770 24/18722 0.635263252164727 0.780452856394683 GATA2 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/770 24/18722 0.635263252164727 0.780452856394683 AKT1S1 1 GO:0051570 regulation of histone H3-K9 methylation 1/770 24/18722 0.635263252164727 0.780452856394683 LMNA 1 GO:0060149 negative regulation of posttranscriptional gene silencing 1/770 24/18722 0.635263252164727 0.780452856394683 NEAT1 1 GO:0060479 lung cell differentiation 1/770 24/18722 0.635263252164727 0.780452856394683 CTNNB1 1 GO:0060967 negative regulation of gene silencing by RNA 1/770 24/18722 0.635263252164727 0.780452856394683 NEAT1 1 GO:0061162 establishment of monopolar cell polarity 1/770 24/18722 0.635263252164727 0.780452856394683 OPHN1 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/770 24/18722 0.635263252164727 0.780452856394683 LARP4B 1 GO:0071577 zinc ion transmembrane transport 1/770 24/18722 0.635263252164727 0.780452856394683 SLC39A7 1 GO:0072010 glomerular epithelium development 1/770 24/18722 0.635263252164727 0.780452856394683 BASP1 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/770 24/18722 0.635263252164727 0.780452856394683 VCP 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/770 24/18722 0.635263252164727 0.780452856394683 CLCN3 1 GO:1903861 positive regulation of dendrite extension 1/770 24/18722 0.635263252164727 0.780452856394683 NEDD4L 1 GO:2000209 regulation of anoikis 1/770 24/18722 0.635263252164727 0.780452856394683 BCL2 1 GO:2000310 regulation of NMDA receptor activity 1/770 24/18722 0.635263252164727 0.780452856394683 APP 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/770 24/18722 0.635263252164727 0.780452856394683 PDCD4 1 GO:2001026 regulation of endothelial cell chemotaxis 1/770 24/18722 0.635263252164727 0.780452856394683 HSPB1 1 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 3/770 79/18722 0.636162685721908 0.78079580687822 ERBB3/PPARD/MYDGF 3 GO:0060420 regulation of heart growth 3/770 79/18722 0.636162685721908 0.78079580687822 BASP1/DUSP9/TGFBR3 3 GO:2001257 regulation of cation channel activity 7/770 184/18722 0.636507803737174 0.78079580687822 APP/EHD3/P2RY6/KLHL24/KCNG1/UBQLN1/STOM 7 GO:0030514 negative regulation of BMP signaling pathway 2/770 52/18722 0.636639246106002 0.78079580687822 GREM2/CRIM1 2 GO:0031103 axon regeneration 2/770 52/18722 0.636639246106002 0.78079580687822 BCL2/LRP1 2 GO:0051496 positive regulation of stress fiber assembly 2/770 52/18722 0.636639246106002 0.78079580687822 NRP1/FERMT2 2 GO:0072132 mesenchyme morphogenesis 2/770 52/18722 0.636639246106002 0.78079580687822 TBX3/MDM2 2 GO:0045637 regulation of myeloid cell differentiation 8/770 210/18722 0.637412682093915 0.781552016455211 CSF3R/CEBPB/SCIN/NFKBIA/GATA2/ID2/CTNNB1/HSPA1B 8 GO:0032259 methylation 14/770 364/18722 0.639811919976854 0.784300811130298 GATA3/ETF1/MBD3/BTG1/KMT2C/TET2/MLLT6/LMNA/CTNNB1/PCMTD1/SUPT6H/IWS1/BRD4/RNMT 14 GO:0009636 response to toxic substance 10/770 262/18722 0.640271762251897 0.784671468593507 NUPR1/GPX3/SDC1/BCL2/MDM2/MGST3/KDM5B/PRDX6/SOD1/NFE2L2 10 GO:0007422 peripheral nervous system development 3/770 80/18722 0.644625199548141 0.788793168094775 ERBB3/ITGB4/SOD1 3 GO:0048145 regulation of fibroblast proliferation 3/770 80/18722 0.644625199548141 0.788793168094775 NUPR1/CTNNB1/MIF 3 GO:0006275 regulation of DNA replication 4/770 107/18722 0.646499088388452 0.788793168094775 EGFR/ZBTB38/ATF1/RBBP6 4 GO:0021761 limbic system development 4/770 107/18722 0.646499088388452 0.788793168094775 TBX3/GLI3/NRP1/PAFAH1B1 4 GO:0071868 cellular response to monoamine stimulus 4/770 107/18722 0.646499088388452 0.788793168094775 APP/TGM2/GNAS/SLC9A1 4 GO:0071870 cellular response to catecholamine stimulus 4/770 107/18722 0.646499088388452 0.788793168094775 APP/TGM2/GNAS/SLC9A1 4 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/770 53/18722 0.646981807848615 0.788793168094775 ARRDC3/ADM 2 GO:0051438 regulation of ubiquitin-protein transferase activity 2/770 53/18722 0.646981807848615 0.788793168094775 ARRDC3/SKP1 2 GO:0071715 icosanoid transport 2/770 53/18722 0.646981807848615 0.788793168094775 ANXA1/PNPLA8 2 GO:0030258 lipid modification 8/770 212/18722 0.647910528847806 0.788793168094775 ST3GAL4/MTMR10/PLPP3/ABCG1/PPARD/IRS2/ACADVL/SYNJ1 8 GO:0043271 negative regulation of ion transport 6/770 160/18722 0.648255891473925 0.788793168094775 SLC43A2/NEDD4L/BCL2/GABRE/UBQLN1/COMMD1 6 GO:0032147 activation of protein kinase activity 5/770 134/18722 0.649992602571275 0.788793168094775 PRKCZ/GHR/SOCS1/PDPK1/PRLR 5 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 1/770 25/18722 0.650283430570608 0.788793168094775 HSD11B2 1 GO:0007274 neuromuscular synaptic transmission 1/770 25/18722 0.650283430570608 0.788793168094775 ERC1 1 GO:0007288 sperm axoneme assembly 1/770 25/18722 0.650283430570608 0.788793168094775 UBE2B 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/770 25/18722 0.650283430570608 0.788793168094775 AK3 1 GO:0016540 protein autoprocessing 1/770 25/18722 0.650283430570608 0.788793168094775 CTSL 1 GO:0031579 membrane raft organization 1/770 25/18722 0.650283430570608 0.788793168094775 CLN3 1 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1/770 25/18722 0.650283430570608 0.788793168094775 CD55 1 GO:0032104 regulation of response to extracellular stimulus 1/770 25/18722 0.650283430570608 0.788793168094775 NUCB2 1 GO:0032107 regulation of response to nutrient levels 1/770 25/18722 0.650283430570608 0.788793168094775 NUCB2 1 GO:0032925 regulation of activin receptor signaling pathway 1/770 25/18722 0.650283430570608 0.788793168094775 DACT2 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/770 25/18722 0.650283430570608 0.788793168094775 FAR2 1 GO:0046039 GTP metabolic process 1/770 25/18722 0.650283430570608 0.788793168094775 AK3 1 GO:0046339 diacylglycerol metabolic process 1/770 25/18722 0.650283430570608 0.788793168094775 PNPLA2 1 GO:0048596 embryonic camera-type eye morphogenesis 1/770 25/18722 0.650283430570608 0.788793168094775 TFAP2A 1 GO:0050927 positive regulation of positive chemotaxis 1/770 25/18722 0.650283430570608 0.788793168094775 PGF 1 GO:0050951 sensory perception of temperature stimulus 1/770 25/18722 0.650283430570608 0.788793168094775 NR2F6 1 GO:0051204 protein insertion into mitochondrial membrane 1/770 25/18722 0.650283430570608 0.788793168094775 HSP90AA1 1 GO:0051788 response to misfolded protein 1/770 25/18722 0.650283430570608 0.788793168094775 VCP 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/770 25/18722 0.650283430570608 0.788793168094775 OPHN1 1 GO:0062009 secondary palate development 1/770 25/18722 0.650283430570608 0.788793168094775 TGFBR3 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/770 25/18722 0.650283430570608 0.788793168094775 NR2F6 1 GO:0072012 glomerulus vasculature development 1/770 25/18722 0.650283430570608 0.788793168094775 HES1 1 GO:0090330 regulation of platelet aggregation 1/770 25/18722 0.650283430570608 0.788793168094775 C1QTNF1 1 GO:0120316 sperm flagellum assembly 1/770 25/18722 0.650283430570608 0.788793168094775 UBE2B 1 GO:1902993 positive regulation of amyloid precursor protein catabolic process 1/770 25/18722 0.650283430570608 0.788793168094775 ABCG1 1 GO:1903055 positive regulation of extracellular matrix organization 1/770 25/18722 0.650283430570608 0.788793168094775 PHLDB2 1 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 1/770 25/18722 0.650283430570608 0.788793168094775 EGFR 1 GO:1904385 cellular response to angiotensin 1/770 25/18722 0.650283430570608 0.788793168094775 NFE2L2 1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 1/770 25/18722 0.650283430570608 0.788793168094775 ST3GAL4 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/770 25/18722 0.650283430570608 0.788793168094775 PDPK1 1 GO:0006096 glycolytic process 3/770 81/18722 0.652947594506529 0.791254344218393 NUPR1/APP/BPGM 3 GO:0048144 fibroblast proliferation 3/770 81/18722 0.652947594506529 0.791254344218393 NUPR1/CTNNB1/MIF 3 GO:0051149 positive regulation of muscle cell differentiation 3/770 81/18722 0.652947594506529 0.791254344218393 HOPX/BCL2/MDM2 3 GO:1903533 regulation of protein targeting 3/770 81/18722 0.652947594506529 0.791254344218393 TCAF1/LEPROT/STOM 3 GO:0002687 positive regulation of leukocyte migration 5/770 135/18722 0.656441588043694 0.79395672752628 PGF/APP/SERPINE1/AKIRIN1/CALR 5 GO:0042157 lipoprotein metabolic process 5/770 135/18722 0.656441588043694 0.79395672752628 OLR1/ZDHHC3/ZDHHC20/LDLR/LRP1 5 GO:0001706 endoderm formation 2/770 54/18722 0.657089613549745 0.79395672752628 DUSP5/CTNNB1 2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 2/770 54/18722 0.657089613549745 0.79395672752628 HMOX1/GATA2 2 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/770 54/18722 0.657089613549745 0.79395672752628 CD55/CD46 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/770 54/18722 0.657089613549745 0.79395672752628 P2RY6/PDPK1 2 GO:0014888 striated muscle adaptation 2/770 54/18722 0.657089613549745 0.79395672752628 LMNA/ERRFI1 2 GO:0030520 intracellular estrogen receptor signaling pathway 2/770 54/18722 0.657089613549745 0.79395672752628 EGLN2/UBA5 2 GO:0043647 inositol phosphate metabolic process 2/770 54/18722 0.657089613549745 0.79395672752628 P2RY6/SYNJ1 2 GO:0070839 metal ion export 2/770 54/18722 0.657089613549745 0.79395672752628 SLC40A1/SLC9A1 2 GO:1902743 regulation of lamellipodium organization 2/770 54/18722 0.657089613549745 0.79395672752628 AKIRIN1/KANK1 2 GO:2000300 regulation of synaptic vesicle exocytosis 2/770 54/18722 0.657089613549745 0.79395672752628 RAP1B/RAB5A 2 GO:0032496 response to lipopolysaccharide 13/770 343/18722 0.658174372628885 0.795074642135693 PDCD4/KMO/CEBPB/CD55/GNG12/SERPINE1/NFKBIA/CD274/JUND/PPARD/AKIRIN2/ADM/HSPD1 13 GO:0034766 negative regulation of ion transmembrane transport 4/770 109/18722 0.660837294676459 0.796184979943038 SLC43A2/NEDD4L/UBQLN1/COMMD1 4 GO:0002312 B cell activation involved in immune response 3/770 82/18722 0.661129581732444 0.796184979943038 TFRC/SUPT6H/HSPD1 3 GO:0006757 ATP generation from ADP 3/770 82/18722 0.661129581732444 0.796184979943038 NUPR1/APP/BPGM 3 GO:0016575 histone deacetylation 3/770 82/18722 0.661129581732444 0.796184979943038 SIN3B/HOPX/HDAC5 3 GO:0001573 ganglioside metabolic process 1/770 26/18722 0.664685835152125 0.796184979943038 NEU1 1 GO:0002407 dendritic cell chemotaxis 1/770 26/18722 0.664685835152125 0.796184979943038 CALR 1 GO:0003416 endochondral bone growth 1/770 26/18722 0.664685835152125 0.796184979943038 ANXA6 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/770 26/18722 0.664685835152125 0.796184979943038 GABRE 1 GO:0009164 nucleoside catabolic process 1/770 26/18722 0.664685835152125 0.796184979943038 PNP 1 GO:0009435 NAD biosynthetic process 1/770 26/18722 0.664685835152125 0.796184979943038 KMO 1 GO:0014829 vascular associated smooth muscle contraction 1/770 26/18722 0.664685835152125 0.796184979943038 PIK3C2A 1 GO:0021680 cerebellar Purkinje cell layer development 1/770 26/18722 0.664685835152125 0.796184979943038 HSPA5 1 GO:0021952 central nervous system projection neuron axonogenesis 1/770 26/18722 0.664685835152125 0.796184979943038 PAFAH1B1 1 GO:0032682 negative regulation of chemokine production 1/770 26/18722 0.664685835152125 0.796184979943038 ARG2 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/770 26/18722 0.664685835152125 0.796184979943038 ARMCX3 1 GO:0042278 purine nucleoside metabolic process 1/770 26/18722 0.664685835152125 0.796184979943038 PNP 1 GO:0042537 benzene-containing compound metabolic process 1/770 26/18722 0.664685835152125 0.796184979943038 KMO 1 GO:0042634 regulation of hair cycle 1/770 26/18722 0.664685835152125 0.796184979943038 NUMA1 1 GO:0045026 plasma membrane fusion 1/770 26/18722 0.664685835152125 0.796184979943038 SPESP1 1 GO:0047497 mitochondrion transport along microtubule 1/770 26/18722 0.664685835152125 0.796184979943038 ARMCX3 1 GO:0048499 synaptic vesicle membrane organization 1/770 26/18722 0.664685835152125 0.796184979943038 SNAP23 1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 1/770 26/18722 0.664685835152125 0.796184979943038 KCNN4 1 GO:0050926 regulation of positive chemotaxis 1/770 26/18722 0.664685835152125 0.796184979943038 PGF 1 GO:0051016 barbed-end actin filament capping 1/770 26/18722 0.664685835152125 0.796184979943038 SCIN 1 GO:0060295 regulation of cilium movement involved in cell motility 1/770 26/18722 0.664685835152125 0.796184979943038 CCSAP 1 GO:0060352 cell adhesion molecule production 1/770 26/18722 0.664685835152125 0.796184979943038 COLEC12 1 GO:0070102 interleukin-6-mediated signaling pathway 1/770 26/18722 0.664685835152125 0.796184979943038 CEBPA 1 GO:0070193 synaptonemal complex organization 1/770 26/18722 0.664685835152125 0.796184979943038 UBE2B 1 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 1/770 26/18722 0.664685835152125 0.796184979943038 EGFR 1 GO:0070977 bone maturation 1/770 26/18722 0.664685835152125 0.796184979943038 PHOSPHO1 1 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1/770 26/18722 0.664685835152125 0.796184979943038 ARRDC3 1 GO:1900017 positive regulation of cytokine production involved in inflammatory response 1/770 26/18722 0.664685835152125 0.796184979943038 KPNA6 1 GO:1902019 regulation of cilium-dependent cell motility 1/770 26/18722 0.664685835152125 0.796184979943038 CCSAP 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/770 26/18722 0.664685835152125 0.796184979943038 PDCD4 1 GO:1905523 positive regulation of macrophage migration 1/770 26/18722 0.664685835152125 0.796184979943038 AKIRIN1 1 GO:0050657 nucleic acid transport 6/770 163/18722 0.665871084238934 0.797221435070305 MVP/RBM8A/SUPT6H/IWS1/EIF4A3/ALYREF 6 GO:0050658 RNA transport 6/770 163/18722 0.665871084238934 0.797221435070305 MVP/RBM8A/SUPT6H/IWS1/EIF4A3/ALYREF 6 GO:0003179 heart valve morphogenesis 2/770 55/18722 0.666964452332197 0.798338665859077 GATA3/MDM2 2 GO:0009063 cellular amino acid catabolic process 4/770 110/18722 0.667856954135626 0.798831301598134 KMO/ARG2/HIBADH/CDO1 4 GO:0032611 interleukin-1 beta production 4/770 110/18722 0.667856954135626 0.798831301598134 HSPB1/ARG2/APP/ERRFI1 4 GO:0032651 regulation of interleukin-1 beta production 4/770 110/18722 0.667856954135626 0.798831301598134 HSPB1/ARG2/APP/ERRFI1 4 GO:0009612 response to mechanical stimulus 8/770 216/18722 0.668374143590511 0.799258065157551 SLC2A1/EGFR/NFKBIA/JUND/TMEM150C/JUP/CTNNB1/SLC9A1 8 GO:0010948 negative regulation of cell cycle process 11/770 294/18722 0.668560204388502 0.799288747233182 NABP1/OVOL1/BCL2/FOXO4/MDM2/CDK2/PPP1R10/GIGYF2/USP47/TAOK1/CHMP2A 11 GO:0045471 response to ethanol 5/770 137/18722 0.669109196048676 0.799612987419792 GATA3/GGH/CDO1/PSMD14/SOD1 5 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 12/770 320/18722 0.669312817685722 0.799612987419792 MBNL3/SAP18/RBM8A/RBM42/SRSF5/CWC25/EIF4A3/MFAP1/PRDX6/ALYREF/HSPA8/SRRM2 12 GO:0000398 mRNA splicing, via spliceosome 12/770 320/18722 0.669312817685722 0.799612987419792 MBNL3/SAP18/RBM8A/RBM42/SRSF5/CWC25/EIF4A3/MFAP1/PRDX6/ALYREF/HSPA8/SRRM2 12 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 4/770 111/18722 0.6747764235855 0.800981944023858 EGFR/ERBB3/PPARD/MYDGF 4 GO:0071867 response to monoamine 4/770 111/18722 0.6747764235855 0.800981944023858 APP/TGM2/GNAS/SLC9A1 4 GO:0071869 response to catecholamine 4/770 111/18722 0.6747764235855 0.800981944023858 APP/TGM2/GNAS/SLC9A1 4 GO:0007224 smoothened signaling pathway 5/770 138/18722 0.675326844838649 0.800981944023858 HES1/GLI3/VCP/DLG5/GPC3 5 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/770 56/18722 0.676608363120685 0.800981944023858 DHX36/AGO2 2 GO:0015800 acidic amino acid transport 2/770 56/18722 0.676608363120685 0.800981944023858 KMO/CLN8 2 GO:0006405 RNA export from nucleus 3/770 84/18722 0.677071951869456 0.800981944023858 SUPT6H/IWS1/ALYREF 3 GO:0009953 dorsal/ventral pattern formation 3/770 84/18722 0.677071951869456 0.800981944023858 DDIT3/GLI3/CTNNB1 3 GO:0042310 vasoconstriction 3/770 84/18722 0.677071951869456 0.800981944023858 PIK3C2A/EGFR/ADM 3 GO:0061157 mRNA destabilization 3/770 84/18722 0.677071951869456 0.800981944023858 DHX36/GIGYF2/AGO2 3 GO:1900542 regulation of purine nucleotide metabolic process 3/770 84/18722 0.677071951869456 0.800981944023858 NUPR1/APP/VCP 3 GO:0007286 spermatid development 6/770 165/18722 0.677301021674584 0.800981944023858 UBE2B/CDYL/TBC1D20/DYNLL1/AFF4/PAFAH1B1 6 GO:0000027 ribosomal large subunit assembly 1/770 27/18722 0.678495843011179 0.800981944023858 DDX28 1 GO:0001835 blastocyst hatching 1/770 27/18722 0.678495843011179 0.800981944023858 UBE2A 1 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1/770 27/18722 0.678495843011179 0.800981944023858 VAV3 1 GO:0002719 negative regulation of cytokine production involved in immune response 1/770 27/18722 0.678495843011179 0.800981944023858 HMOX1 1 GO:0002825 regulation of T-helper 1 type immune response 1/770 27/18722 0.678495843011179 0.800981944023858 ANXA1 1 GO:0003171 atrioventricular valve development 1/770 27/18722 0.678495843011179 0.800981944023858 MDM2 1 GO:0003272 endocardial cushion formation 1/770 27/18722 0.678495843011179 0.800981944023858 TBX3 1 GO:0003401 axis elongation 1/770 27/18722 0.678495843011179 0.800981944023858 RDH10 1 GO:0006783 heme biosynthetic process 1/770 27/18722 0.678495843011179 0.800981944023858 ALAS1 1 GO:0007263 nitric oxide mediated signal transduction 1/770 27/18722 0.678495843011179 0.800981944023858 EGFR 1 GO:0007628 adult walking behavior 1/770 27/18722 0.678495843011179 0.800981944023858 CLN8 1 GO:0008053 mitochondrial fusion 1/770 27/18722 0.678495843011179 0.800981944023858 TFRC 1 GO:0010528 regulation of transposition 1/770 27/18722 0.678495843011179 0.800981944023858 ZNF91 1 GO:0010529 negative regulation of transposition 1/770 27/18722 0.678495843011179 0.800981944023858 ZNF91 1 GO:0010586 miRNA metabolic process 1/770 27/18722 0.678495843011179 0.800981944023858 AGO2 1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 1/770 27/18722 0.678495843011179 0.800981944023858 SLC9A1 1 GO:0015813 L-glutamate transmembrane transport 1/770 27/18722 0.678495843011179 0.800981944023858 CLN8 1 GO:0018904 ether metabolic process 1/770 27/18722 0.678495843011179 0.800981944023858 PAFAH1B1 1 GO:0032967 positive regulation of collagen biosynthetic process 1/770 27/18722 0.678495843011179 0.800981944023858 SUCO 1 GO:0033688 regulation of osteoblast proliferation 1/770 27/18722 0.678495843011179 0.800981944023858 BCL2 1 GO:0034377 plasma lipoprotein particle assembly 1/770 27/18722 0.678495843011179 0.800981944023858 ARF1 1 GO:0034453 microtubule anchoring 1/770 27/18722 0.678495843011179 0.800981944023858 HOOK3 1 GO:0034698 response to gonadotropin 1/770 27/18722 0.678495843011179 0.800981944023858 TGFBR3 1 GO:0035188 hatching 1/770 27/18722 0.678495843011179 0.800981944023858 UBE2A 1 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 1/770 27/18722 0.678495843011179 0.800981944023858 VAV3 1 GO:0045830 positive regulation of isotype switching 1/770 27/18722 0.678495843011179 0.800981944023858 TFRC 1 GO:0046174 polyol catabolic process 1/770 27/18722 0.678495843011179 0.800981944023858 SYNJ1 1 GO:0046337 phosphatidylethanolamine metabolic process 1/770 27/18722 0.678495843011179 0.800981944023858 PNPLA8 1 GO:0051953 negative regulation of amine transport 1/770 27/18722 0.678495843011179 0.800981944023858 SLC43A2 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/770 27/18722 0.678495843011179 0.800981944023858 SOCS1 1 GO:0071684 organism emergence from protective structure 1/770 27/18722 0.678495843011179 0.800981944023858 UBE2A 1 GO:0099625 ventricular cardiac muscle cell membrane repolarization 1/770 27/18722 0.678495843011179 0.800981944023858 AKAP9 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/770 27/18722 0.678495843011179 0.800981944023858 AKAP9 1 GO:1902883 negative regulation of response to oxidative stress 1/770 27/18722 0.678495843011179 0.800981944023858 NFE2L2 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/770 27/18722 0.678495843011179 0.800981944023858 CTNNB1 1 GO:1903205 regulation of hydrogen peroxide-induced cell death 1/770 27/18722 0.678495843011179 0.800981944023858 NFE2L2 1 GO:1903421 regulation of synaptic vesicle recycling 1/770 27/18722 0.678495843011179 0.800981944023858 AP2M1 1 GO:2000463 positive regulation of excitatory postsynaptic potential 1/770 27/18722 0.678495843011179 0.800981944023858 PRKCZ 1 GO:0002526 acute inflammatory response 4/770 112/18722 0.681595394887301 0.804259969861099 NUPR1/CEBPB/GATA3/EIF2AK1 4 GO:0035601 protein deacylation 4/770 112/18722 0.681595394887301 0.804259969861099 SIN3B/HOPX/HDAC5/BEX4 4 GO:0002253 activation of immune response 14/770 375/18722 0.682837823166901 0.805442265005451 GATA3/CD55/VAV3/HEXIM1/EZR/KCNN4/BCL2/TNFRSF21/CD46/DUSP3/CD59/TBK1/EIF2B2/HSP90AA1 14 GO:0051236 establishment of RNA localization 6/770 166/18722 0.682920644119613 0.805442265005451 MVP/RBM8A/SUPT6H/IWS1/EIF4A3/ALYREF 6 GO:0071805 potassium ion transmembrane transport 8/770 219/18722 0.683243075924785 0.805631861650072 NEDD4L/KCNN4/CD63/AKAP9/KLHL24/SLC12A4/SLC9A1/KCNG1 8 GO:0032092 positive regulation of protein binding 3/770 85/18722 0.68483250741875 0.806239541090736 APP/LRP1/NRP1 3 GO:0055013 cardiac muscle cell development 3/770 85/18722 0.68483250741875 0.806239541090736 TBX3/NEBL/LMNA 3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 7/770 193/18722 0.685255707036154 0.806239541090736 HES1/GHR/ERBB3/RICTOR/OSBP/NRP1/MIF 7 GO:0000375 RNA splicing, via transesterification reactions 12/770 324/18722 0.685682349260059 0.806239541090736 MBNL3/SAP18/RBM8A/RBM42/SRSF5/CWC25/EIF4A3/MFAP1/PRDX6/ALYREF/HSPA8/SRRM2 12 GO:0006611 protein export from nucleus 2/770 57/18722 0.686023611122762 0.806239541090736 MDM2/CALR 2 GO:0010257 NADH dehydrogenase complex assembly 2/770 57/18722 0.686023611122762 0.806239541090736 NDUFA6/NDUFB9 2 GO:0032981 mitochondrial respiratory chain complex I assembly 2/770 57/18722 0.686023611122762 0.806239541090736 NDUFA6/NDUFB9 2 GO:0050879 multicellular organismal movement 2/770 57/18722 0.686023611122762 0.806239541090736 CLN8/GIGYF2 2 GO:0050881 musculoskeletal movement 2/770 57/18722 0.686023611122762 0.806239541090736 CLN8/GIGYF2 2 GO:0051155 positive regulation of striated muscle cell differentiation 2/770 57/18722 0.686023611122762 0.806239541090736 HOPX/BCL2 2 GO:0051205 protein insertion into membrane 2/770 57/18722 0.686023611122762 0.806239541090736 EGFR/HSP90AA1 2 GO:0051289 protein homotetramerization 2/770 57/18722 0.686023611122762 0.806239541090736 GOLGA2/USP16 2 GO:0060042 retina morphogenesis in camera-type eye 2/770 57/18722 0.686023611122762 0.806239541090736 TFAP2A/RDH13 2 GO:1902017 regulation of cilium assembly 2/770 57/18722 0.686023611122762 0.806239541090736 LIMK2/CDKL5 2 GO:0031333 negative regulation of protein-containing complex assembly 5/770 140/18722 0.687527850529239 0.806865498146815 PRKCZ/SCIN/HSPA5/DDX3X/KANK1 5 GO:0022618 ribonucleoprotein complex assembly 8/770 220/18722 0.688106292069474 0.806865498146815 EIF5/DDX28/EIF2S2/SRSF5/EIF4H/AGO2/HSP90AA1/EIF3J 8 GO:0001578 microtubule bundle formation 4/770 113/18722 0.688313645939978 0.806865498146815 CLIP1/UBE2B/CAPN6/NUMA1 4 GO:0071347 cellular response to interleukin-1 4/770 113/18722 0.688313645939978 0.806865498146815 KMO/CEBPB/TANK/RPS6KA5 4 GO:0002285 lymphocyte activation involved in immune response 7/770 194/18722 0.690406143101559 0.806865498146815 ANXA1/PRKCZ/TFRC/GATA3/CD46/SUPT6H/HSPD1 7 GO:0003156 regulation of animal organ formation 1/770 28/18722 0.691737790102989 0.806865498146815 CTNNB1 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/770 28/18722 0.691737790102989 0.806865498146815 VCP 1 GO:0006829 zinc ion transport 1/770 28/18722 0.691737790102989 0.806865498146815 SLC39A7 1 GO:0007141 male meiosis I 1/770 28/18722 0.691737790102989 0.806865498146815 SLC2A8 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/770 28/18722 0.691737790102989 0.806865498146815 LRP1 1 GO:0009065 glutamine family amino acid catabolic process 1/770 28/18722 0.691737790102989 0.806865498146815 ARG2 1 GO:0009312 oligosaccharide biosynthetic process 1/770 28/18722 0.691737790102989 0.806865498146815 ST3GAL4 1 GO:0010460 positive regulation of heart rate 1/770 28/18722 0.691737790102989 0.806865498146815 ADM 1 GO:0010714 positive regulation of collagen metabolic process 1/770 28/18722 0.691737790102989 0.806865498146815 SUCO 1 GO:0010884 positive regulation of lipid storage 1/770 28/18722 0.691737790102989 0.806865498146815 PLIN2 1 GO:0015740 C4-dicarboxylate transport 1/770 28/18722 0.691737790102989 0.806865498146815 SLC13A3 1 GO:0019098 reproductive behavior 1/770 28/18722 0.691737790102989 0.806865498146815 APP 1 GO:0030262 apoptotic nuclear changes 1/770 28/18722 0.691737790102989 0.806865498146815 DEDD2 1 GO:0031342 negative regulation of cell killing 1/770 28/18722 0.691737790102989 0.806865498146815 SERPINB9 1 GO:0032958 inositol phosphate biosynthetic process 1/770 28/18722 0.691737790102989 0.806865498146815 P2RY6 1 GO:0034123 positive regulation of toll-like receptor signaling pathway 1/770 28/18722 0.691737790102989 0.806865498146815 DDX3X 1 GO:0038094 Fc-gamma receptor signaling pathway 1/770 28/18722 0.691737790102989 0.806865498146815 VAV3 1 GO:0045671 negative regulation of osteoclast differentiation 1/770 28/18722 0.691737790102989 0.806865498146815 CTNNB1 1 GO:0060765 regulation of androgen receptor signaling pathway 1/770 28/18722 0.691737790102989 0.806865498146815 DAB2 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/770 28/18722 0.691737790102989 0.806865498146815 PMAIP1 1 GO:0090344 negative regulation of cell aging 1/770 28/18722 0.691737790102989 0.806865498146815 MIF 1 GO:0090659 walking behavior 1/770 28/18722 0.691737790102989 0.806865498146815 CLN8 1 GO:0099623 regulation of cardiac muscle cell membrane repolarization 1/770 28/18722 0.691737790102989 0.806865498146815 AKAP9 1 GO:1903671 negative regulation of sprouting angiogenesis 1/770 28/18722 0.691737790102989 0.806865498146815 SEMA6A 1 GO:1903672 positive regulation of sprouting angiogenesis 1/770 28/18722 0.691737790102989 0.806865498146815 PDPK1 1 GO:1903779 regulation of cardiac conduction 1/770 28/18722 0.691737790102989 0.806865498146815 EHD3 1 GO:1990776 response to angiotensin 1/770 28/18722 0.691737790102989 0.806865498146815 NFE2L2 1 GO:0006140 regulation of nucleotide metabolic process 3/770 86/18722 0.692452985048494 0.807321765207451 NUPR1/APP/VCP 3 GO:0046928 regulation of neurotransmitter secretion 3/770 86/18722 0.692452985048494 0.807321765207451 KMO/RAP1B/RAB5A 3 GO:0071219 cellular response to molecule of bacterial origin 8/770 221/18722 0.692922459632503 0.807680144175149 PDCD4/KMO/CEBPB/CD55/SERPINE1/NFKBIA/CD274/PPARD 8 GO:0035296 regulation of tube diameter 5/770 141/18722 0.693510588978394 0.807987670067649 PIK3C2A/EGFR/PPARD/ADM/SOD1 5 GO:0097746 blood vessel diameter maintenance 5/770 141/18722 0.693510588978394 0.807987670067649 PIK3C2A/EGFR/PPARD/ADM/SOD1 5 GO:0002833 positive regulation of response to biotic stimulus 6/770 168/18722 0.693967470991772 0.80833097427583 HEXIM1/CD274/AKIRIN2/TBK1/HSP90AA1/HSPD1 6 GO:0002286 T cell activation involved in immune response 4/770 114/18722 0.694931037402183 0.80921390183801 ANXA1/PRKCZ/GATA3/CD46 4 GO:0032387 negative regulation of intracellular transport 2/770 58/18722 0.695212665817484 0.80921390183801 ERLEC1/INSIG1 2 GO:0086065 cell communication involved in cardiac conduction 2/770 58/18722 0.695212665817484 0.80921390183801 DSP/JUP 2 GO:0035150 regulation of tube size 5/770 142/18722 0.699414498362963 0.813676326901453 PIK3C2A/EGFR/PPARD/ADM/SOD1 5 GO:0001776 leukocyte homeostasis 3/770 87/18722 0.699933799875573 0.813676326901453 ANXA1/PMAIP1/BCL2 3 GO:0061014 positive regulation of mRNA catabolic process 3/770 87/18722 0.699933799875573 0.813676326901453 DHX36/GIGYF2/AGO2 3 GO:1901606 alpha-amino acid catabolic process 3/770 87/18722 0.699933799875573 0.813676326901453 KMO/ARG2/CDO1 3 GO:1903578 regulation of ATP metabolic process 3/770 87/18722 0.699933799875573 0.813676326901453 NUPR1/APP/VCP 3 GO:0030278 regulation of ossification 4/770 115/18722 0.701447509454031 0.813676326901453 TFAP2A/BCL2/PHOSPHO1/PBX1 4 GO:0090630 activation of GTPase activity 4/770 115/18722 0.701447509454031 0.813676326901453 EIF5/TBC1D9/ARHGAP24/RABGAP1 4 GO:0002820 negative regulation of adaptive immune response 2/770 59/18722 0.704178180367843 0.813676326901453 CD55/CD46 2 GO:0019369 arachidonic acid metabolic process 2/770 59/18722 0.704178180367843 0.813676326901453 CYP2J2/PNPLA8 2 GO:0032768 regulation of monooxygenase activity 2/770 59/18722 0.704178180367843 0.813676326901453 EGFR/GLA 2 GO:0043407 negative regulation of MAP kinase activity 2/770 59/18722 0.704178180367843 0.813676326901453 PDCD4/DNAJA1 2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/770 59/18722 0.704178180367843 0.813676326901453 VAV3/SOCS1 2 GO:0071806 protein transmembrane transport 2/770 59/18722 0.704178180367843 0.813676326901453 HSPA5/HSPD1 2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 1/770 29/18722 0.704435013897826 0.813676326901453 AGO2 1 GO:0006734 NADH metabolic process 1/770 29/18722 0.704435013897826 0.813676326901453 VCP 1 GO:0007143 female meiotic nuclear division 1/770 29/18722 0.704435013897826 0.813676326901453 SPIRE2 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/770 29/18722 0.704435013897826 0.813676326901453 AK3 1 GO:0010592 positive regulation of lamellipodium assembly 1/770 29/18722 0.704435013897826 0.813676326901453 AKIRIN1 1 GO:0019359 nicotinamide nucleotide biosynthetic process 1/770 29/18722 0.704435013897826 0.813676326901453 KMO 1 GO:0019363 pyridine nucleotide biosynthetic process 1/770 29/18722 0.704435013897826 0.813676326901453 KMO 1 GO:0034311 diol metabolic process 1/770 29/18722 0.704435013897826 0.813676326901453 PLPP3 1 GO:0048265 response to pain 1/770 29/18722 0.704435013897826 0.813676326901453 VWA1 1 GO:0048665 neuron fate specification 1/770 29/18722 0.704435013897826 0.813676326901453 GLI3 1 GO:0048679 regulation of axon regeneration 1/770 29/18722 0.704435013897826 0.813676326901453 LRP1 1 GO:0048753 pigment granule organization 1/770 29/18722 0.704435013897826 0.813676326901453 BCL2 1 GO:0051654 establishment of mitochondrion localization 1/770 29/18722 0.704435013897826 0.813676326901453 ARMCX3 1 GO:0060969 negative regulation of gene silencing 1/770 29/18722 0.704435013897826 0.813676326901453 NEAT1 1 GO:0062098 regulation of programmed necrotic cell death 1/770 29/18722 0.704435013897826 0.813676326901453 NUPR1 1 GO:0070198 protein localization to chromosome, telomeric region 1/770 29/18722 0.704435013897826 0.813676326901453 TNKS2 1 GO:0090025 regulation of monocyte chemotaxis 1/770 29/18722 0.704435013897826 0.813676326901453 SERPINE1 1 GO:0098868 bone growth 1/770 29/18722 0.704435013897826 0.813676326901453 ANXA6 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/770 29/18722 0.704435013897826 0.813676326901453 NEDD4L 1 GO:2000406 positive regulation of T cell migration 1/770 29/18722 0.704435013897826 0.813676326901453 APP 1 GO:0050779 RNA destabilization 3/770 88/18722 0.707275485408321 0.816767959163305 DHX36/GIGYF2/AGO2 3 GO:0018107 peptidyl-threonine phosphorylation 4/770 116/18722 0.707863078602286 0.816878582833532 APP/BCL2/PDPK1/TBK1 4 GO:0051283 negative regulation of sequestering of calcium ion 4/770 116/18722 0.707863078602286 0.816878582833532 DDIT3/ANXA6/P2RY6/PDPK1 4 GO:0098732 macromolecule deacylation 4/770 116/18722 0.707863078602286 0.816878582833532 SIN3B/HOPX/HDAC5/BEX4 4 GO:0006302 double-strand break repair 9/770 251/18722 0.709149760509905 0.81817394225998 OTUB2/NABP1/SPIRE2/VCP/UBR5/UVRAG/PPP4R2/SWI5/PSMD14 9 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 2/770 60/18722 0.712922972377335 0.820511742481878 NFKBIA/HSPA1B 2 GO:0006289 nucleotide-excision repair 2/770 60/18722 0.712922972377335 0.820511742481878 DDB1/COMMD1 2 GO:0031663 lipopolysaccharide-mediated signaling pathway 2/770 60/18722 0.712922972377335 0.820511742481878 CD55/NFKBIA 2 GO:0055008 cardiac muscle tissue morphogenesis 2/770 60/18722 0.712922972377335 0.820511742481878 DSP/TGFBR3 2 GO:1903670 regulation of sprouting angiogenesis 2/770 60/18722 0.712922972377335 0.820511742481878 SEMA6A/PDPK1 2 GO:0003002 regionalization 12/770 331/18722 0.713152553995664 0.820511742481878 TBX3/BASP1/HES1/DDIT3/GLI3/MIB1/BHLHE40/ADGRG1/CTNNB1/NRP1/GPC3/PBX1 12 GO:0072676 lymphocyte migration 4/770 117/18722 0.714177834532272 0.820511742481878 GATA3/APP/CD200/WASL 4 GO:0046330 positive regulation of JNK cascade 3/770 89/18722 0.714478686606178 0.820511742481878 GADD45G/APP/TAOK1 3 GO:0048515 spermatid differentiation 6/770 172/18722 0.715284309411936 0.820511742481878 UBE2B/CDYL/TBC1D20/DYNLL1/AFF4/PAFAH1B1 6 GO:0006099 tricarboxylic acid cycle 1/770 30/18722 0.716609894296836 0.820511742481878 ACO2 1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/770 30/18722 0.716609894296836 0.820511742481878 DEDD2 1 GO:0009072 aromatic amino acid family metabolic process 1/770 30/18722 0.716609894296836 0.820511742481878 KMO 1 GO:0009264 deoxyribonucleotide catabolic process 1/770 30/18722 0.716609894296836 0.820511742481878 PNP 1 GO:0010453 regulation of cell fate commitment 1/770 30/18722 0.716609894296836 0.820511742481878 HES1 1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 1/770 30/18722 0.716609894296836 0.820511742481878 APP 1 GO:0019674 NAD metabolic process 1/770 30/18722 0.716609894296836 0.820511742481878 KMO 1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 1/770 30/18722 0.716609894296836 0.820511742481878 CTSL 1 GO:0030204 chondroitin sulfate metabolic process 1/770 30/18722 0.716609894296836 0.820511742481878 CHPF 1 GO:0034368 protein-lipid complex remodeling 1/770 30/18722 0.716609894296836 0.820511742481878 ABCG1 1 GO:0034369 plasma lipoprotein particle remodeling 1/770 30/18722 0.716609894296836 0.820511742481878 ABCG1 1 GO:0034390 smooth muscle cell apoptotic process 1/770 30/18722 0.716609894296836 0.820511742481878 PDCD4 1 GO:0034391 regulation of smooth muscle cell apoptotic process 1/770 30/18722 0.716609894296836 0.820511742481878 PDCD4 1 GO:0044030 regulation of DNA methylation 1/770 30/18722 0.716609894296836 0.820511742481878 MBD3 1 GO:0045577 regulation of B cell differentiation 1/770 30/18722 0.716609894296836 0.820511742481878 ID2 1 GO:0045948 positive regulation of translational initiation 1/770 30/18722 0.716609894296836 0.820511742481878 DDX3X 1 GO:0046825 regulation of protein export from nucleus 1/770 30/18722 0.716609894296836 0.820511742481878 MDM2 1 GO:0048147 negative regulation of fibroblast proliferation 1/770 30/18722 0.716609894296836 0.820511742481878 NUPR1 1 GO:0060292 long-term synaptic depression 1/770 30/18722 0.716609894296836 0.820511742481878 ARF1 1 GO:0061311 cell surface receptor signaling pathway involved in heart development 1/770 30/18722 0.716609894296836 0.820511742481878 CTNNB1 1 GO:0061384 heart trabecula morphogenesis 1/770 30/18722 0.716609894296836 0.820511742481878 TGFBR3 1 GO:0070498 interleukin-1-mediated signaling pathway 1/770 30/18722 0.716609894296836 0.820511742481878 RPS6KA5 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/770 30/18722 0.716609894296836 0.820511742481878 HSP90AA1 1 GO:1903579 negative regulation of ATP metabolic process 1/770 30/18722 0.716609894296836 0.820511742481878 NUPR1 1 GO:0051282 regulation of sequestering of calcium ion 4/770 118/18722 0.720391937009487 0.824652658423678 DDIT3/ANXA6/P2RY6/PDPK1 4 GO:0045638 negative regulation of myeloid cell differentiation 3/770 90/18722 0.72154415316593 0.825402781273147 NFKBIA/GATA2/CTNNB1 3 GO:0048477 oogenesis 3/770 90/18722 0.72154415316593 0.825402781273147 BCL2/DIAPH2/CTNNB1 3 GO:0097581 lamellipodium organization 3/770 90/18722 0.72154415316593 0.825402781273147 VAV3/AKIRIN1/KANK1 3 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 5/770 146/18722 0.722239161006326 0.82600820272998 ARRDC3/LGR4/GNAS/ADGRG1/ADM 5 GO:0006403 RNA localization 7/770 201/18722 0.724920833282464 0.828736843614455 DHX36/MVP/RBM8A/SUPT6H/IWS1/EIF4A3/ALYREF 7 GO:0000280 nuclear division 16/770 439/18722 0.725499922859359 0.828736843614455 UBE2B/RAB11A/SPIRE2/GOLGA2/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CALR/CHMP4B/SLC2A8/EML4/USP16/CHMP2A/UBE2I 16 GO:0002440 production of molecular mediator of immune response 11/770 308/18722 0.725898034562734 0.828736843614455 PRKCZ/TFRC/HMOX1/GATA3/CD55/SLC7A5/SEMA7A/DHX36/DNAJB9/SUPT6H/HSPD1 11 GO:0060041 retina development in camera-type eye 5/770 147/18722 0.727747346815315 0.828736843614455 TFAP2A/RDH13/CLN8/NRP1/SERPINF1 5 GO:0001782 B cell homeostasis 1/770 31/18722 0.728283892873309 0.828736843614455 BCL2 1 GO:0002230 positive regulation of defense response to virus by host 1/770 31/18722 0.728283892873309 0.828736843614455 HSP90AA1 1 GO:0006613 cotranslational protein targeting to membrane 1/770 31/18722 0.728283892873309 0.828736843614455 SIL1 1 GO:0006779 porphyrin-containing compound biosynthetic process 1/770 31/18722 0.728283892873309 0.828736843614455 ALAS1 1 GO:0033014 tetrapyrrole biosynthetic process 1/770 31/18722 0.728283892873309 0.828736843614455 ALAS1 1 GO:0033238 regulation of cellular amine metabolic process 1/770 31/18722 0.728283892873309 0.828736843614455 CLN3 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/770 31/18722 0.728283892873309 0.828736843614455 PNP 1 GO:0036474 cell death in response to hydrogen peroxide 1/770 31/18722 0.728283892873309 0.828736843614455 NFE2L2 1 GO:0036475 neuron death in response to oxidative stress 1/770 31/18722 0.728283892873309 0.828736843614455 CTNNB1 1 GO:0043171 peptide catabolic process 1/770 31/18722 0.728283892873309 0.828736843614455 ENPEP 1 GO:0046386 deoxyribose phosphate catabolic process 1/770 31/18722 0.728283892873309 0.828736843614455 PNP 1 GO:0055075 potassium ion homeostasis 1/770 31/18722 0.728283892873309 0.828736843614455 SLC12A4 1 GO:0060045 positive regulation of cardiac muscle cell proliferation 1/770 31/18722 0.728283892873309 0.828736843614455 TGFBR3 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/770 31/18722 0.728283892873309 0.828736843614455 CTNNB1 1 GO:0070633 transepithelial transport 1/770 31/18722 0.728283892873309 0.828736843614455 P2RY6 1 GO:0070723 response to cholesterol 1/770 31/18722 0.728283892873309 0.828736843614455 GRAMD1C 1 GO:0071168 protein localization to chromatin 1/770 31/18722 0.728283892873309 0.828736843614455 VCP 1 GO:0097106 postsynaptic density organization 1/770 31/18722 0.728283892873309 0.828736843614455 OPHN1 1 GO:0051952 regulation of amine transport 3/770 91/18722 0.72847273303347 0.828762472307255 KMO/SLC43A2/SYT7 3 GO:0002260 lymphocyte homeostasis 2/770 62/18722 0.729762374738366 0.829850733300155 PMAIP1/BCL2 2 GO:0032731 positive regulation of interleukin-1 beta production 2/770 62/18722 0.729762374738366 0.829850733300155 HSPB1/APP 2 GO:0050954 sensory perception of mechanical stimulus 6/770 175/18722 0.730587154729758 0.830599085562031 TFAP2A/DDIT3/SLC52A3/MYO6/NDUFB9/SOD1 6 GO:0002761 regulation of myeloid leukocyte differentiation 4/770 120/18722 0.732519152847203 0.832605597316973 CEBPB/GATA2/ID2/CTNNB1 4 GO:0002237 response to molecule of bacterial origin 13/770 363/18722 0.734092866047636 0.834204048236117 PDCD4/KMO/CEBPB/CD55/GNG12/SERPINE1/NFKBIA/CD274/JUND/PPARD/AKIRIN2/ADM/HSPD1 13 GO:1903312 negative regulation of mRNA metabolic process 3/770 92/18722 0.735265366139577 0.835345946072392 SAP18/LARP4B/RBM42 3 GO:0001947 heart looping 2/770 63/18722 0.737863286643447 0.837077881304113 TBX3/MIB1 2 GO:0022617 extracellular matrix disassembly 2/770 63/18722 0.737863286643447 0.837077881304113 FURIN/LRP1 2 GO:0030239 myofibril assembly 2/770 63/18722 0.737863286643447 0.837077881304113 KRT8/NEBL 2 GO:0016525 negative regulation of angiogenesis 5/770 149/18722 0.73852646656437 0.837077881304113 SEMA6A/SERPINE1/FOXO4/CTNNB1/SERPINF1 5 GO:0003180 aortic valve morphogenesis 1/770 32/18722 0.739477590507868 0.837077881304113 GATA3 1 GO:0032196 transposition 1/770 32/18722 0.739477590507868 0.837077881304113 ZNF91 1 GO:0033687 osteoblast proliferation 1/770 32/18722 0.739477590507868 0.837077881304113 BCL2 1 GO:0034367 protein-containing complex remodeling 1/770 32/18722 0.739477590507868 0.837077881304113 ABCG1 1 GO:0042219 cellular modified amino acid catabolic process 1/770 32/18722 0.739477590507868 0.837077881304113 MTHFS 1 GO:0050850 positive regulation of calcium-mediated signaling 1/770 32/18722 0.739477590507868 0.837077881304113 SLC9A1 1 GO:0061036 positive regulation of cartilage development 1/770 32/18722 0.739477590507868 0.837077881304113 GLI3 1 GO:0071875 adrenergic receptor signaling pathway 1/770 32/18722 0.739477590507868 0.837077881304113 ARRDC3 1 GO:0090022 regulation of neutrophil chemotaxis 1/770 32/18722 0.739477590507868 0.837077881304113 MPP1 1 GO:0097345 mitochondrial outer membrane permeabilization 1/770 32/18722 0.739477590507868 0.837077881304113 SLC25A5 1 GO:1903955 positive regulation of protein targeting to mitochondrion 1/770 32/18722 0.739477590507868 0.837077881304113 LEPROT 1 GO:2000191 regulation of fatty acid transport 1/770 32/18722 0.739477590507868 0.837077881304113 IRS2 1 GO:0032755 positive regulation of interleukin-6 production 3/770 93/18722 0.74192307835765 0.839464736479603 APP/AKIRIN2/HSPD1 3 GO:0033273 response to vitamin 3/770 93/18722 0.74192307835765 0.839464736479603 EGFR/PPARD/MDM2 3 GO:0051928 positive regulation of calcium ion transport 4/770 122/18722 0.744247291480681 0.84190334925045 EHD3/P2RY6/PDPK1/SLC9A1 4 GO:0030837 negative regulation of actin filament polymerization 2/770 64/18722 0.745756048882468 0.842338899305269 SCIN/KANK1 2 GO:0045670 regulation of osteoclast differentiation 2/770 64/18722 0.745756048882468 0.842338899305269 CEBPB/CTNNB1 2 GO:0046579 positive regulation of Ras protein signal transduction 2/770 64/18722 0.745756048882468 0.842338899305269 ADGRG1/LRRC59 2 GO:0046888 negative regulation of hormone secretion 2/770 64/18722 0.745756048882468 0.842338899305269 PIM3/RAB11FIP1 2 GO:0006260 DNA replication 9/770 260/18722 0.746892793788803 0.842338899305269 EGFR/TOP1/ZBTB38/RBMS1/CDK2/ATF1/RBBP7/RBBP6/ALYREF 9 GO:0009615 response to virus 13/770 367/18722 0.747880988934901 0.842338899305269 HSPB1/PMAIP1/GATA3/SERINC5/BCL2/IFI6/DHX36/IL10RB/ARF1/DDX3X/LGALS8/TBK1/HSP90AA1 13 GO:2000181 negative regulation of blood vessel morphogenesis 5/770 151/18722 0.748990211795039 0.842338899305269 SEMA6A/SERPINE1/FOXO4/CTNNB1/SERPINF1 5 GO:0001881 receptor recycling 1/770 33/18722 0.750210723483199 0.842338899305269 EHD3 1 GO:0001975 response to amphetamine 1/770 33/18722 0.750210723483199 0.842338899305269 SOD1 1 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/770 33/18722 0.750210723483199 0.842338899305269 VAV3 1 GO:0006536 glutamate metabolic process 1/770 33/18722 0.750210723483199 0.842338899305269 MTHFS 1 GO:0006654 phosphatidic acid biosynthetic process 1/770 33/18722 0.750210723483199 0.842338899305269 ABHD5 1 GO:0010259 multicellular organism aging 1/770 33/18722 0.750210723483199 0.842338899305269 SERP1 1 GO:0019362 pyridine nucleotide metabolic process 1/770 33/18722 0.750210723483199 0.842338899305269 KMO 1 GO:0021696 cerebellar cortex morphogenesis 1/770 33/18722 0.750210723483199 0.842338899305269 OPHN1 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/770 33/18722 0.750210723483199 0.842338899305269 PDCD6 1 GO:0035025 positive regulation of Rho protein signal transduction 1/770 33/18722 0.750210723483199 0.842338899305269 ADGRG1 1 GO:0036336 dendritic cell migration 1/770 33/18722 0.750210723483199 0.842338899305269 CALR 1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1/770 33/18722 0.750210723483199 0.842338899305269 VAV3 1 GO:0046496 nicotinamide nucleotide metabolic process 1/770 33/18722 0.750210723483199 0.842338899305269 KMO 1 GO:0048333 mesodermal cell differentiation 1/770 33/18722 0.750210723483199 0.842338899305269 ITGB4 1 GO:0050901 leukocyte tethering or rolling 1/770 33/18722 0.750210723483199 0.842338899305269 ST3GAL4 1 GO:0070570 regulation of neuron projection regeneration 1/770 33/18722 0.750210723483199 0.842338899305269 LRP1 1 GO:0071295 cellular response to vitamin 1/770 33/18722 0.750210723483199 0.842338899305269 MDM2 1 GO:0099084 postsynaptic specialization organization 1/770 33/18722 0.750210723483199 0.842338899305269 OPHN1 1 GO:0099174 regulation of presynapse organization 1/770 33/18722 0.750210723483199 0.842338899305269 APP 1 GO:1900181 negative regulation of protein localization to nucleus 1/770 33/18722 0.750210723483199 0.842338899305269 LATS2 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/770 33/18722 0.750210723483199 0.842338899305269 NEDD4L 1 GO:1901976 regulation of cell cycle checkpoint 1/770 33/18722 0.750210723483199 0.842338899305269 PPP1R10 1 GO:1902275 regulation of chromatin organization 1/770 33/18722 0.750210723483199 0.842338899305269 TLK1 1 GO:1903146 regulation of autophagy of mitochondrion 1/770 33/18722 0.750210723483199 0.842338899305269 SLC25A5 1 GO:1905606 regulation of presynapse assembly 1/770 33/18722 0.750210723483199 0.842338899305269 APP 1 GO:2000036 regulation of stem cell population maintenance 1/770 33/18722 0.750210723483199 0.842338899305269 NCOA3 1 GO:0043489 RNA stabilization 2/770 65/18722 0.753444054583405 0.845757794308672 DHX36/LARP4B 2 GO:0006874 cellular calcium ion homeostasis 16/770 448/18722 0.753845755582949 0.845757794308672 CD55/APP/BCL2/TGM2/DDIT3/ANXA6/HERPUD1/GATA2/P2RY6/CLN3/GPR157/PDPK1/C1QTNF1/LRP1/CALR/ADM 16 GO:0050871 positive regulation of B cell activation 5/770 152/18722 0.754104330747227 0.845757794308672 TFRC/VAV3/BCL2/IRS2/MIF 5 GO:0098754 detoxification 5/770 152/18722 0.754104330747227 0.845757794308672 GPX3/MGST3/PRDX6/SOD1/NFE2L2 5 GO:1901343 negative regulation of vasculature development 5/770 152/18722 0.754104330747227 0.845757794308672 SEMA6A/SERPINE1/FOXO4/CTNNB1/SERPINF1 5 GO:0001662 behavioral fear response 1/770 34/18722 0.760502218101314 0.849967925293895 BCL2 1 GO:0002446 neutrophil mediated immunity 1/770 34/18722 0.760502218101314 0.849967925293895 STXBP3 1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 1/770 34/18722 0.760502218101314 0.849967925293895 CTSL 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/770 34/18722 0.760502218101314 0.849967925293895 PDCD4 1 GO:0031128 developmental induction 1/770 34/18722 0.760502218101314 0.849967925293895 CTNNB1 1 GO:0042573 retinoic acid metabolic process 1/770 34/18722 0.760502218101314 0.849967925293895 RDH10 1 GO:0043276 anoikis 1/770 34/18722 0.760502218101314 0.849967925293895 BCL2 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/770 34/18722 0.760502218101314 0.849967925293895 LRPAP1 1 GO:0048741 skeletal muscle fiber development 1/770 34/18722 0.760502218101314 0.849967925293895 BCL2 1 GO:0048854 brain morphogenesis 1/770 34/18722 0.760502218101314 0.849967925293895 PAFAH1B1 1 GO:0055094 response to lipoprotein particle 1/770 34/18722 0.760502218101314 0.849967925293895 LDLR 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/770 34/18722 0.760502218101314 0.849967925293895 SLC9A1 1 GO:0090075 relaxation of muscle 1/770 34/18722 0.760502218101314 0.849967925293895 SOD1 1 GO:0098751 bone cell development 1/770 34/18722 0.760502218101314 0.849967925293895 PAFAH1B1 1 GO:0006303 double-strand break repair via nonhomologous end joining 2/770 66/18722 0.760930770116587 0.849967925293895 UVRAG/PSMD14 2 GO:0019229 regulation of vasoconstriction 2/770 66/18722 0.760930770116587 0.849967925293895 EGFR/ADM 2 GO:0072678 T cell migration 2/770 66/18722 0.760930770116587 0.849967925293895 APP/CD200 2 GO:0043648 dicarboxylic acid metabolic process 3/770 96/18722 0.761098116792334 0.849967925293895 KMO/SLC19A1/MTHFS 3 GO:0018210 peptidyl-threonine modification 4/770 125/18722 0.761099113518234 0.849967925293895 APP/BCL2/PDPK1/TBK1 4 GO:0051260 protein homooligomerization 6/770 182/18722 0.764007332916204 0.852744100328126 GOLGA2/EHD3/KCNG1/MIF/USP16/CHMP2A 6 GO:0016052 carbohydrate catabolic process 5/770 154/18722 0.764098416208124 0.852744100328126 NUPR1/APP/BPGM/NEU1/PPP1CB 5 GO:0051168 nuclear export 5/770 154/18722 0.764098416208124 0.852744100328126 MDM2/SUPT6H/IWS1/CALR/ALYREF 5 GO:0007204 positive regulation of cytosolic calcium ion concentration 11/770 319/18722 0.766169766510006 0.854864296130622 CD55/BCL2/TGM2/DDIT3/GATA2/P2RY6/GPR157/PDPK1/C1QTNF1/LRP1/ADM 11 GO:0032874 positive regulation of stress-activated MAPK cascade 4/770 126/18722 0.766521170570993 0.855064918951256 GADD45G/APP/MAP3K4/TAOK1 4 GO:0010596 negative regulation of endothelial cell migration 3/770 97/18722 0.767227923775081 0.855661760109944 HDAC5/JUP/SERPINF1 3 GO:0061371 determination of heart left/right asymmetry 2/770 67/18722 0.768219723352666 0.85590966011431 TBX3/MIB1 2 GO:0002209 behavioral defense response 1/770 35/18722 0.77037022388374 0.85590966011431 BCL2 1 GO:0006084 acetyl-CoA metabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 ACSS1 1 GO:0006691 leukotriene metabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 MGST3 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/770 35/18722 0.77037022388374 0.85590966011431 EML4 1 GO:0009119 ribonucleoside metabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 PNP 1 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 1/770 35/18722 0.77037022388374 0.85590966011431 UBA5 1 GO:0035633 maintenance of blood-brain barrier 1/770 35/18722 0.77037022388374 0.85590966011431 LSR 1 GO:0042462 eye photoreceptor cell development 1/770 35/18722 0.77037022388374 0.85590966011431 RDH13 1 GO:0043243 positive regulation of protein-containing complex disassembly 1/770 35/18722 0.77037022388374 0.85590966011431 UVRAG 1 GO:0044273 sulfur compound catabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 CDO1 1 GO:0045907 positive regulation of vasoconstriction 1/770 35/18722 0.77037022388374 0.85590966011431 EGFR 1 GO:0046471 phosphatidylglycerol metabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 PNPLA8 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/770 35/18722 0.77037022388374 0.85590966011431 CHPF 1 GO:0098810 neurotransmitter reuptake 1/770 35/18722 0.77037022388374 0.85590966011431 CLN8 1 GO:0106056 regulation of calcineurin-mediated signaling 1/770 35/18722 0.77037022388374 0.85590966011431 SLC9A1 1 GO:2000403 positive regulation of lymphocyte migration 1/770 35/18722 0.77037022388374 0.85590966011431 APP 1 GO:0006911 phagocytosis, engulfment 4/770 127/18722 0.771846682016583 0.857358898013516 RHOBTB1/GULP1/GATA2/CLCN3 4 GO:0050851 antigen receptor-mediated signaling pathway 8/770 240/18722 0.775268575792415 0.860443678713713 GATA3/VAV3/EZR/KCNN4/BCL2/TNFRSF21/DUSP3/EIF2B2 8 GO:0009247 glycolipid biosynthetic process 2/770 68/18722 0.7753144927603 0.860443678713713 ST3GAL4/B3GNT5 2 GO:0042987 amyloid precursor protein catabolic process 2/770 68/18722 0.7753144927603 0.860443678713713 ABCG1/CLN3 2 GO:0051926 negative regulation of calcium ion transport 2/770 68/18722 0.7753144927603 0.860443678713713 BCL2/UBQLN1 2 GO:0006639 acylglycerol metabolic process 4/770 128/18722 0.777076350515986 0.860855910631571 ABHD5/LDLR/PNPLA2/INSIG1 4 GO:0033865 nucleoside bisphosphate metabolic process 4/770 128/18722 0.777076350515986 0.860855910631571 SLC26A2/FAR2/ACSS1/SLC25A16 4 GO:0033875 ribonucleoside bisphosphate metabolic process 4/770 128/18722 0.777076350515986 0.860855910631571 SLC26A2/FAR2/ACSS1/SLC25A16 4 GO:0034032 purine nucleoside bisphosphate metabolic process 4/770 128/18722 0.777076350515986 0.860855910631571 SLC26A2/FAR2/ACSS1/SLC25A16 4 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 4/770 128/18722 0.777076350515986 0.860855910631571 GADD45G/APP/MAP3K4/TAOK1 4 GO:0003300 cardiac muscle hypertrophy 3/770 99/18722 0.779102868463296 0.860855910631571 LMNA/SLC9A1/ERRFI1 3 GO:0006165 nucleoside diphosphate phosphorylation 3/770 99/18722 0.779102868463296 0.860855910631571 NUPR1/APP/BPGM 3 GO:0015837 amine transport 3/770 99/18722 0.779102868463296 0.860855910631571 KMO/SLC43A2/SYT7 3 GO:0031341 regulation of cell killing 3/770 99/18722 0.779102868463296 0.860855910631571 CD55/SERPINB9/CD59 3 GO:0051153 regulation of striated muscle cell differentiation 3/770 99/18722 0.779102868463296 0.860855910631571 HOPX/BCL2/HDAC5 3 GO:0002691 regulation of cellular extravasation 1/770 36/18722 0.779832145412585 0.860855910631571 ST3GAL4 1 GO:0003230 cardiac atrium development 1/770 36/18722 0.779832145412585 0.860855910631571 MDM2 1 GO:0003352 regulation of cilium movement 1/770 36/18722 0.779832145412585 0.860855910631571 CCSAP 1 GO:0006699 bile acid biosynthetic process 1/770 36/18722 0.779832145412585 0.860855910631571 OSBP 1 GO:0007031 peroxisome organization 1/770 36/18722 0.779832145412585 0.860855910631571 ZFAND6 1 GO:0014046 dopamine secretion 1/770 36/18722 0.779832145412585 0.860855910631571 SYT7 1 GO:0014059 regulation of dopamine secretion 1/770 36/18722 0.779832145412585 0.860855910631571 SYT7 1 GO:0042119 neutrophil activation 1/770 36/18722 0.779832145412585 0.860855910631571 STXBP3 1 GO:0042755 eating behavior 1/770 36/18722 0.779832145412585 0.860855910631571 GDF15 1 GO:0044060 regulation of endocrine process 1/770 36/18722 0.779832145412585 0.860855910631571 C1QTNF1 1 GO:0044743 protein transmembrane import into intracellular organelle 1/770 36/18722 0.779832145412585 0.860855910631571 HSPD1 1 GO:0051354 negative regulation of oxidoreductase activity 1/770 36/18722 0.779832145412585 0.860855910631571 GLA 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/770 36/18722 0.779832145412585 0.860855910631571 TBK1 1 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 1/770 36/18722 0.779832145412585 0.860855910631571 LEPROT 1 GO:0006638 neutral lipid metabolic process 4/770 129/18722 0.782210918587812 0.862916929072034 ABHD5/LDLR/PNPLA2/INSIG1 4 GO:0007498 mesoderm development 4/770 129/18722 0.782210918587812 0.862916929072034 TBX3/OVOL1/MEST/ITGB4 4 GO:0019226 transmission of nerve impulse 2/770 69/18722 0.782218697294476 0.862916929072034 PAFAH1B1/SOD1 2 GO:0006626 protein targeting to mitochondrion 3/770 100/18722 0.784850909213313 0.864965461686615 LEPROT/HSP90AA1/HSPD1 3 GO:0044728 DNA methylation or demethylation 3/770 100/18722 0.784850909213313 0.864965461686615 GATA3/MBD3/TET2 3 GO:0051588 regulation of neurotransmitter transport 3/770 100/18722 0.784850909213313 0.864965461686615 KMO/RAP1B/RAB5A 3 GO:0060079 excitatory postsynaptic potential 3/770 100/18722 0.784850909213313 0.864965461686615 PRKCZ/APP/EIF4A3 3 GO:0007601 visual perception 7/770 215/18722 0.785774801395437 0.864965461686615 EPAS1/PITPNA/ATXN7/CLN8/RDH10/RP2/EFEMP1 7 GO:0072503 cellular divalent inorganic cation homeostasis 17/770 486/18722 0.786972306397864 0.864965461686615 CD55/APP/BCL2/TGM2/DDIT3/ANXA6/HERPUD1/GATA2/P2RY6/SLC39A7/CLN3/GPR157/PDPK1/C1QTNF1/LRP1/CALR/ADM 17 GO:1903169 regulation of calcium ion transmembrane transport 5/770 159/18722 0.787734383149497 0.864965461686615 EHD3/P2RY6/PDPK1/SLC9A1/UBQLN1 5 GO:0055074 calcium ion homeostasis 16/770 460/18722 0.788546133129001 0.864965461686615 CD55/APP/BCL2/TGM2/DDIT3/ANXA6/HERPUD1/GATA2/P2RY6/CLN3/GPR157/PDPK1/C1QTNF1/LRP1/CALR/ADM 16 GO:0003176 aortic valve development 1/770 37/18722 0.788904672868023 0.864965461686615 GATA3 1 GO:0006904 vesicle docking involved in exocytosis 1/770 37/18722 0.788904672868023 0.864965461686615 STXBP3 1 GO:0007340 acrosome reaction 1/770 37/18722 0.788904672868023 0.864965461686615 SPESP1 1 GO:0014904 myotube cell development 1/770 37/18722 0.788904672868023 0.864965461686615 BCL2 1 GO:0032570 response to progesterone 1/770 37/18722 0.788904672868023 0.864965461686615 CLDN4 1 GO:0034260 negative regulation of GTPase activity 1/770 37/18722 0.788904672868023 0.864965461686615 SH3BP4 1 GO:0042178 xenobiotic catabolic process 1/770 37/18722 0.788904672868023 0.864965461686615 CYP2J2 1 GO:0043687 post-translational protein modification 1/770 37/18722 0.788904672868023 0.864965461686615 UBE2M 1 GO:0045730 respiratory burst 1/770 37/18722 0.788904672868023 0.864965461686615 CD55 1 GO:0046473 phosphatidic acid metabolic process 1/770 37/18722 0.788904672868023 0.864965461686615 ABHD5 1 GO:0051567 histone H3-K9 methylation 1/770 37/18722 0.788904672868023 0.864965461686615 LMNA 1 GO:0051954 positive regulation of amine transport 1/770 37/18722 0.788904672868023 0.864965461686615 KMO 1 GO:0060428 lung epithelium development 1/770 37/18722 0.788904672868023 0.864965461686615 ERRFI1 1 GO:0072529 pyrimidine-containing compound catabolic process 1/770 37/18722 0.788904672868023 0.864965461686615 TET2 1 GO:0090218 positive regulation of lipid kinase activity 1/770 37/18722 0.788904672868023 0.864965461686615 VAV3 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/770 37/18722 0.788904672868023 0.864965461686615 PDCD4 1 GO:1902745 positive regulation of lamellipodium organization 1/770 37/18722 0.788904672868023 0.864965461686615 AKIRIN1 1 GO:0002548 monocyte chemotaxis 2/770 70/18722 0.788935987029031 0.864965461686615 ANXA1/SERPINE1 2 GO:0003407 neural retina development 2/770 70/18722 0.788935987029031 0.864965461686615 TFAP2A/RDH13 2 GO:0060415 muscle tissue morphogenesis 2/770 70/18722 0.788935987029031 0.864965461686615 DSP/TGFBR3 2 GO:0051480 regulation of cytosolic calcium ion concentration 12/770 353/18722 0.789267201768136 0.865138246020814 CD55/BCL2/TGM2/DDIT3/GATA2/P2RY6/CLN3/GPR157/PDPK1/C1QTNF1/LRP1/ADM 12 GO:0034655 nucleobase-containing compound catabolic process 14/770 407/18722 0.789768290886831 0.865497117547631 PNP/ETF1/ERN1/VCP/DHX36/RNASEH2C/DEDD2/LARP4B/RBM8A/XRN1/GIGYF2/HSPA1B/EIF4A3/AGO2 14 GO:0046939 nucleotide phosphorylation 3/770 101/18722 0.790474675900924 0.866080762975881 NUPR1/APP/BPGM 3 GO:0045089 positive regulation of innate immune response 4/770 131/18722 0.792197908687844 0.867778012528364 HEXIM1/AKIRIN2/TBK1/HSP90AA1 4 GO:0033555 multicellular organismal response to stress 2/770 71/18722 0.795470034489377 0.870065628674534 BCL2/VWA1 2 GO:0006325 chromatin organization 14/770 409/18722 0.795503835939092 0.870065628674534 TOP1/GATA3/TLK1/MBD3/BCORL1/HDAC5/BRD2/KDM5B/SUPT6H/RBBP7/BRD4/CHD2/ARID4B/HMG20B 14 GO:0010522 regulation of calcium ion transport into cytosol 3/770 102/18722 0.79597573112016 0.870065628674534 BCL2/P2RY6/PDPK1 3 GO:0014897 striated muscle hypertrophy 3/770 102/18722 0.79597573112016 0.870065628674534 LMNA/SLC9A1/ERRFI1 3 GO:0002478 antigen processing and presentation of exogenous peptide antigen 1/770 38/18722 0.797603811315527 0.870065628674534 CTSL 1 GO:0006858 extracellular transport 1/770 38/18722 0.797603811315527 0.870065628674534 TSG101 1 GO:0006882 cellular zinc ion homeostasis 1/770 38/18722 0.797603811315527 0.870065628674534 SLC39A7 1 GO:0007007 inner mitochondrial membrane organization 1/770 38/18722 0.797603811315527 0.870065628674534 GHITM 1 GO:0010613 positive regulation of cardiac muscle hypertrophy 1/770 38/18722 0.797603811315527 0.870065628674534 SLC9A1 1 GO:0030279 negative regulation of ossification 1/770 38/18722 0.797603811315527 0.870065628674534 BCL2 1 GO:0035337 fatty-acyl-CoA metabolic process 1/770 38/18722 0.797603811315527 0.870065628674534 FAR2 1 GO:0042596 fear response 1/770 38/18722 0.797603811315527 0.870065628674534 BCL2 1 GO:0046676 negative regulation of insulin secretion 1/770 38/18722 0.797603811315527 0.870065628674534 PIM3 1 GO:0051930 regulation of sensory perception of pain 1/770 38/18722 0.797603811315527 0.870065628674534 SLC9A1 1 GO:0071398 cellular response to fatty acid 1/770 38/18722 0.797603811315527 0.870065628674534 LDLR 1 GO:0099622 cardiac muscle cell membrane repolarization 1/770 38/18722 0.797603811315527 0.870065628674534 AKAP9 1 GO:1901031 regulation of response to reactive oxygen species 1/770 38/18722 0.797603811315527 0.870065628674534 NFE2L2 1 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1/770 38/18722 0.797603811315527 0.870065628674534 SLC25A5 1 GO:2000279 negative regulation of DNA biosynthetic process 1/770 38/18722 0.797603811315527 0.870065628674534 XRN1 1 GO:0022412 cellular process involved in reproduction in multicellular organism 13/770 384/18722 0.801101231892509 0.872949883387836 UBE2B/CDYL/BCL2/SPIRE2/TBC1D20/EIF2S2/DIAPH2/CTNNB1/DYNLL1/AFF4/PAFAH1B1/SLC2A8/SPESP1 13 GO:0050953 sensory perception of light stimulus 7/770 219/18722 0.801177660885711 0.872949883387836 EPAS1/PITPNA/ATXN7/CLN8/RDH10/RP2/EFEMP1 7 GO:0019233 sensory perception of pain 3/770 103/18722 0.801355674493178 0.872949883387836 MME/NR2F6/SLC9A1 3 GO:0019395 fatty acid oxidation 3/770 103/18722 0.801355674493178 0.872949883387836 PPARD/IRS2/ACADVL 3 GO:0009855 determination of bilateral symmetry 4/770 133/18722 0.801814301403853 0.872949883387836 TBX3/DDIT3/MIB1/CTNNB1 4 GO:0002534 cytokine production involved in inflammatory response 2/770 72/18722 0.801824526643814 0.872949883387836 PDCD4/KPNA6 2 GO:0030032 lamellipodium assembly 2/770 72/18722 0.801824526643814 0.872949883387836 VAV3/AKIRIN1 2 GO:0032729 positive regulation of interferon-gamma production 2/770 72/18722 0.801824526643814 0.872949883387836 SLC7A5/HSPD1 2 GO:1900015 regulation of cytokine production involved in inflammatory response 2/770 72/18722 0.801824526643814 0.872949883387836 PDCD4/KPNA6 2 GO:0001941 postsynaptic membrane organization 1/770 39/18722 0.80594490879396 0.875107385118599 RER1 1 GO:0002701 negative regulation of production of molecular mediator of immune response 1/770 39/18722 0.80594490879396 0.875107385118599 HMOX1 1 GO:0007618 mating 1/770 39/18722 0.80594490879396 0.875107385118599 APP 1 GO:0014742 positive regulation of muscle hypertrophy 1/770 39/18722 0.80594490879396 0.875107385118599 SLC9A1 1 GO:0031507 heterochromatin assembly 1/770 39/18722 0.80594490879396 0.875107385118599 MBD3 1 GO:0036297 interstrand cross-link repair 1/770 39/18722 0.80594490879396 0.875107385118599 VCP 1 GO:0042417 dopamine metabolic process 1/770 39/18722 0.80594490879396 0.875107385118599 MAOA 1 GO:0043267 negative regulation of potassium ion transport 1/770 39/18722 0.80594490879396 0.875107385118599 NEDD4L 1 GO:0045823 positive regulation of heart contraction 1/770 39/18722 0.80594490879396 0.875107385118599 ADM 1 GO:0046621 negative regulation of organ growth 1/770 39/18722 0.80594490879396 0.875107385118599 CGA 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/770 39/18722 0.80594490879396 0.875107385118599 HDAC5 1 GO:0051931 regulation of sensory perception 1/770 39/18722 0.80594490879396 0.875107385118599 SLC9A1 1 GO:0009799 specification of symmetry 4/770 134/18722 0.80648573829101 0.875107385118599 TBX3/DDIT3/MIB1/CTNNB1 4 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 3/770 104/18722 0.806616138842008 0.875107385118599 TGM2/P2RY6/GPR157 3 GO:0014896 muscle hypertrophy 3/770 104/18722 0.806616138842008 0.875107385118599 LMNA/SLC9A1/ERRFI1 3 GO:0060419 heart growth 3/770 104/18722 0.806616138842008 0.875107385118599 BASP1/DUSP9/TGFBR3 3 GO:0009166 nucleotide catabolic process 2/770 73/18722 0.808003157514037 0.876039976913065 PNP/VCP 2 GO:0032732 positive regulation of interleukin-1 production 2/770 73/18722 0.808003157514037 0.876039976913065 HSPB1/APP 2 GO:0045739 positive regulation of DNA repair 2/770 73/18722 0.808003157514037 0.876039976913065 EGFR/SPIRE2 2 GO:0006310 DNA recombination 10/770 305/18722 0.809713978133331 0.877703883628103 TFRC/UBE2B/HMGB3/NABP1/SUPT6H/PPP4R2/SWI5/ALYREF/PSMD14/HSPD1 10 GO:0009581 detection of external stimulus 4/770 135/18722 0.81106723906192 0.877777525053996 JUP/OPN3/NR2F6/CTNNB1 4 GO:2001022 positive regulation of response to DNA damage stimulus 3/770 105/18722 0.811758786535606 0.877777525053996 PMAIP1/EGFR/SPIRE2 3 GO:0007281 germ cell development 9/770 278/18722 0.811891366717825 0.877777525053996 UBE2B/CDYL/BCL2/TBC1D20/DIAPH2/CTNNB1/DYNLL1/AFF4/PAFAH1B1 9 GO:0032635 interleukin-6 production 5/770 165/18722 0.813619104958777 0.877777525053996 CEBPB/APP/CD200/AKIRIN2/HSPD1 5 GO:0032675 regulation of interleukin-6 production 5/770 165/18722 0.813619104958777 0.877777525053996 CEBPB/APP/CD200/AKIRIN2/HSPD1 5 GO:0002714 positive regulation of B cell mediated immunity 1/770 40/18722 0.813942683253557 0.877777525053996 TFRC 1 GO:0002891 positive regulation of immunoglobulin mediated immune response 1/770 40/18722 0.813942683253557 0.877777525053996 TFRC 1 GO:0006730 one-carbon metabolic process 1/770 40/18722 0.813942683253557 0.877777525053996 MTHFS 1 GO:0009394 2'-deoxyribonucleotide metabolic process 1/770 40/18722 0.813942683253557 0.877777525053996 PNP 1 GO:0010543 regulation of platelet activation 1/770 40/18722 0.813942683253557 0.877777525053996 C1QTNF1 1 GO:0030501 positive regulation of bone mineralization 1/770 40/18722 0.813942683253557 0.877777525053996 TFAP2A 1 GO:0031297 replication fork processing 1/770 40/18722 0.813942683253557 0.877777525053996 ALYREF 1 GO:0032892 positive regulation of organic acid transport 1/770 40/18722 0.813942683253557 0.877777525053996 KMO 1 GO:0044275 cellular carbohydrate catabolic process 1/770 40/18722 0.813942683253557 0.877777525053996 PPP1CB 1 GO:0045429 positive regulation of nitric oxide biosynthetic process 1/770 40/18722 0.813942683253557 0.877777525053996 HSP90AA1 1 GO:0055069 zinc ion homeostasis 1/770 40/18722 0.813942683253557 0.877777525053996 SLC39A7 1 GO:0055081 anion homeostasis 1/770 40/18722 0.813942683253557 0.877777525053996 SLC12A4 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/770 40/18722 0.813942683253557 0.877777525053996 UBQLN1 1 GO:1901223 negative regulation of NIK/NF-kappaB signaling 1/770 40/18722 0.813942683253557 0.877777525053996 DDX3X 1 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 1/770 40/18722 0.813942683253557 0.877777525053996 SLC25A5 1 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 1/770 40/18722 0.813942683253557 0.877777525053996 ST3GAL4 1 GO:2000781 positive regulation of double-strand break repair 1/770 40/18722 0.813942683253557 0.877777525053996 SPIRE2 1 GO:0010822 positive regulation of mitochondrion organization 2/770 74/18722 0.814009621367553 0.877777525053996 PMAIP1/SLC25A5 2 GO:0048332 mesoderm morphogenesis 2/770 74/18722 0.814009621367553 0.877777525053996 TBX3/ITGB4 2 GO:0006090 pyruvate metabolic process 3/770 106/18722 0.816785306007436 0.880389612769858 NUPR1/APP/BPGM 3 GO:0099565 chemical synaptic transmission, postsynaptic 3/770 106/18722 0.816785306007436 0.880389612769858 PRKCZ/APP/EIF4A3 3 GO:0006631 fatty acid metabolic process 13/770 390/18722 0.817812447474607 0.881306104188142 ANXA1/CYP2J2/AKR1B1/ABHD5/ABHD3/ACSS1/PNPLA8/PPARD/IRS2/ACADVL/AIG1/MIF/INSIG1 13 GO:1902369 negative regulation of RNA catabolic process 2/770 75/18722 0.81984760645675 0.882439264278083 DHX36/LARP4B 2 GO:2001259 positive regulation of cation channel activity 2/770 75/18722 0.81984760645675 0.882439264278083 EHD3/P2RY6 2 GO:0007586 digestion 4/770 137/18722 0.819964291037778 0.882439264278083 SGK1/EZR/KCNN4/LDLR 4 GO:0060078 regulation of postsynaptic membrane potential 4/770 137/18722 0.819964291037778 0.882439264278083 PRKCZ/APP/GABRE/EIF4A3 4 GO:0098813 nuclear chromosome segregation 9/770 281/18722 0.821387062007703 0.882439264278083 UBE2B/RAB11A/CHMP2B/NUMA1/CTNNB1/VPS4B/CHMP4B/EML4/CHMP2A 9 GO:0032735 positive regulation of interleukin-12 production 1/770 41/18722 0.821611248390842 0.882439264278083 HSPD1 1 GO:0050691 regulation of defense response to virus by host 1/770 41/18722 0.821611248390842 0.882439264278083 HSP90AA1 1 GO:0051693 actin filament capping 1/770 41/18722 0.821611248390842 0.882439264278083 SCIN 1 GO:0055023 positive regulation of cardiac muscle tissue growth 1/770 41/18722 0.821611248390842 0.882439264278083 TGFBR3 1 GO:1900371 regulation of purine nucleotide biosynthetic process 1/770 41/18722 0.821611248390842 0.882439264278083 VCP 1 GO:1901385 regulation of voltage-gated calcium channel activity 1/770 41/18722 0.821611248390842 0.882439264278083 EHD3 1 GO:1902622 regulation of neutrophil migration 1/770 41/18722 0.821611248390842 0.882439264278083 MPP1 1 GO:1903524 positive regulation of blood circulation 1/770 41/18722 0.821611248390842 0.882439264278083 ADM 1 GO:1904407 positive regulation of nitric oxide metabolic process 1/770 41/18722 0.821611248390842 0.882439264278083 HSP90AA1 1 GO:1905314 semi-lunar valve development 1/770 41/18722 0.821611248390842 0.882439264278083 GATA3 1 GO:0051341 regulation of oxidoreductase activity 3/770 107/18722 0.821697408438752 0.882439264278083 EGFR/GLA/COX17 3 GO:0000724 double-strand break repair via homologous recombination 4/770 138/18722 0.824281826745214 0.884833335344981 NABP1/PPP4R2/SWI5/PSMD14 4 GO:0009582 detection of abiotic stimulus 4/770 138/18722 0.824281826745214 0.884833335344981 JUP/OPN3/NR2F6/CTNNB1 4 GO:0006839 mitochondrial transport 8/770 254/18722 0.824807185207635 0.885206591404188 PMAIP1/BCL2/SLC25A16/LEPROT/SLC25A5/SLC9A1/HSP90AA1/HSPD1 8 GO:0014823 response to activity 2/770 76/18722 0.825520789271268 0.885282533599378 PPARD/HSPD1 2 GO:0032720 negative regulation of tumor necrosis factor production 2/770 76/18722 0.825520789271268 0.885282533599378 ARG2/ERRFI1 2 GO:0140115 export across plasma membrane 2/770 76/18722 0.825520789271268 0.885282533599378 SLC40A1/SLC9A1 2 GO:0022037 metencephalon development 3/770 108/18722 0.826496824602765 0.885282533599378 BCL2/OPHN1/HSPA5 3 GO:0034440 lipid oxidation 3/770 108/18722 0.826496824602765 0.885282533599378 PPARD/IRS2/ACADVL 3 GO:0006040 amino sugar metabolic process 1/770 42/18722 0.828964138425586 0.885282533599378 CMAS 1 GO:0007212 dopamine receptor signaling pathway 1/770 42/18722 0.828964138425586 0.885282533599378 GNAS 1 GO:0009154 purine ribonucleotide catabolic process 1/770 42/18722 0.828964138425586 0.885282533599378 PNP 1 GO:0010591 regulation of lamellipodium assembly 1/770 42/18722 0.828964138425586 0.885282533599378 AKIRIN1 1 GO:0010677 negative regulation of cellular carbohydrate metabolic process 1/770 42/18722 0.828964138425586 0.885282533599378 NUPR1 1 GO:0010939 regulation of necrotic cell death 1/770 42/18722 0.828964138425586 0.885282533599378 NUPR1 1 GO:0014003 oligodendrocyte development 1/770 42/18722 0.828964138425586 0.885282533599378 EIF2B2 1 GO:0016601 Rac protein signal transduction 1/770 42/18722 0.828964138425586 0.885282533599378 ARHGAP24 1 GO:0019432 triglyceride biosynthetic process 1/770 42/18722 0.828964138425586 0.885282533599378 LDLR 1 GO:0019692 deoxyribose phosphate metabolic process 1/770 42/18722 0.828964138425586 0.885282533599378 PNP 1 GO:0030808 regulation of nucleotide biosynthetic process 1/770 42/18722 0.828964138425586 0.885282533599378 VCP 1 GO:0032691 negative regulation of interleukin-1 beta production 1/770 42/18722 0.828964138425586 0.885282533599378 ERRFI1 1 GO:0045214 sarcomere organization 1/770 42/18722 0.828964138425586 0.885282533599378 KRT8 1 GO:0046596 regulation of viral entry into host cell 1/770 42/18722 0.828964138425586 0.885282533599378 P4HB 1 GO:0055090 acylglycerol homeostasis 1/770 42/18722 0.828964138425586 0.885282533599378 PNPLA8 1 GO:0070328 triglyceride homeostasis 1/770 42/18722 0.828964138425586 0.885282533599378 PNPLA8 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/770 42/18722 0.828964138425586 0.885282533599378 HDAC5 1 GO:1904037 positive regulation of epithelial cell apoptotic process 1/770 42/18722 0.828964138425586 0.885282533599378 PDCD4 1 GO:0009152 purine ribonucleotide biosynthetic process 5/770 169/18722 0.829430119494819 0.885590376139422 SLC26A2/AK3/ACSS1/VCP/SLC25A16 5 GO:0007492 endoderm development 2/770 77/18722 0.831032829272129 0.887111522764143 DUSP5/CTNNB1 2 GO:0000725 recombinational repair 4/770 140/18722 0.832660025284066 0.88846785995514 NABP1/PPP4R2/SWI5/PSMD14 4 GO:0007292 female gamete generation 4/770 140/18722 0.832660025284066 0.88846785995514 BCL2/SPIRE2/DIAPH2/CTNNB1 4 GO:0072522 purine-containing compound biosynthetic process 6/770 200/18722 0.835664843857914 0.890157675181487 SLC26A2/AK3/PNP/ACSS1/VCP/SLC25A16 6 GO:0006939 smooth muscle contraction 3/770 110/18722 0.835764601333873 0.890157675181487 TBX3/PIK3C2A/SOD1 3 GO:0006284 base-excision repair 1/770 43/18722 0.836014331863076 0.890157675181487 USP47 1 GO:0033173 calcineurin-NFAT signaling cascade 1/770 43/18722 0.836014331863076 0.890157675181487 SLC9A1 1 GO:0034142 toll-like receptor 4 signaling pathway 1/770 43/18722 0.836014331863076 0.890157675181487 NFKBIA 1 GO:0042088 T-helper 1 type immune response 1/770 43/18722 0.836014331863076 0.890157675181487 ANXA1 1 GO:0046717 acid secretion 1/770 43/18722 0.836014331863076 0.890157675181487 SGK1 1 GO:0061383 trabecula morphogenesis 1/770 43/18722 0.836014331863076 0.890157675181487 TGFBR3 1 GO:0090278 negative regulation of peptide hormone secretion 1/770 43/18722 0.836014331863076 0.890157675181487 PIM3 1 GO:0030500 regulation of bone mineralization 2/770 78/18722 0.836387364077809 0.890157675181487 TFAP2A/PHOSPHO1 2 GO:0043537 negative regulation of blood vessel endothelial cell migration 2/770 78/18722 0.836387364077809 0.890157675181487 HDAC5/JUP 2 GO:1901616 organic hydroxy compound catabolic process 2/770 78/18722 0.836387364077809 0.890157675181487 MAOA/SYNJ1 2 GO:0006805 xenobiotic metabolic process 3/770 111/18722 0.840236495160216 0.89406330458752 GSTA3/CYP2J2/GSTA4 3 GO:0032272 negative regulation of protein polymerization 2/770 79/18722 0.841588005074066 0.894662166330031 SCIN/KANK1 2 GO:0051279 regulation of release of sequestered calcium ion into cytosol 2/770 79/18722 0.841588005074066 0.894662166330031 P2RY6/PDPK1 2 GO:1903046 meiotic cell cycle process 6/770 202/18722 0.84242263905486 0.894662166330031 UBE2B/OVOL1/SPIRE2/GOLGA2/CALR/SLC2A8 6 GO:0002792 negative regulation of peptide secretion 1/770 44/18722 0.842774274283196 0.894662166330031 PIM3 1 GO:0008542 visual learning 1/770 44/18722 0.842774274283196 0.894662166330031 APP 1 GO:0009262 deoxyribonucleotide metabolic process 1/770 44/18722 0.842774274283196 0.894662166330031 PNP 1 GO:0031295 T cell costimulation 1/770 44/18722 0.842774274283196 0.894662166330031 CD274 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/770 44/18722 0.842774274283196 0.894662166330031 SERPINB9 1 GO:0044058 regulation of digestive system process 1/770 44/18722 0.842774274283196 0.894662166330031 SGK1 1 GO:0046006 regulation of activated T cell proliferation 1/770 44/18722 0.842774274283196 0.894662166330031 CD274 1 GO:1903214 regulation of protein targeting to mitochondrion 1/770 44/18722 0.842774274283196 0.894662166330031 LEPROT 1 GO:0001676 long-chain fatty acid metabolic process 3/770 112/18722 0.844602763975067 0.89622137412431 CYP2J2/PNPLA8/AIG1 3 GO:0010633 negative regulation of epithelial cell migration 3/770 112/18722 0.844602763975067 0.89622137412431 HDAC5/JUP/SERPINF1 3 GO:0051321 meiotic cell cycle 8/770 261/18722 0.846187973973932 0.897712300258059 UBE2B/OVOL1/SPIRE2/GOLGA2/CDK2/NUMA1/CALR/SLC2A8 8 GO:0021766 hippocampus development 2/770 80/18722 0.846638333420885 0.89799889643173 GLI3/PAFAH1B1 2 GO:0007584 response to nutrient 5/770 174/18722 0.847642361811114 0.898671087423521 HMOX1/EGFR/PPARD/MDM2/COX4I1 5 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 7/770 233/18722 0.848467447782112 0.898671087423521 ARRDC3/GNA12/LGR4/GNAI1/GNAS/ADGRG1/ADM 7 GO:0044344 cellular response to fibroblast growth factor stimulus 3/770 113/18722 0.848865194466933 0.898671087423521 GATA3/KDM5B/CTNNB1 3 GO:0022602 ovulation cycle process 1/770 45/18722 0.849255900196139 0.898671087423521 HSPA5 1 GO:0030835 negative regulation of actin filament depolymerization 1/770 45/18722 0.849255900196139 0.898671087423521 SCIN 1 GO:0035384 thioester biosynthetic process 1/770 45/18722 0.849255900196139 0.898671087423521 ACSS1 1 GO:0035987 endodermal cell differentiation 1/770 45/18722 0.849255900196139 0.898671087423521 CTNNB1 1 GO:0071354 cellular response to interleukin-6 1/770 45/18722 0.849255900196139 0.898671087423521 CEBPA 1 GO:0071616 acyl-CoA biosynthetic process 1/770 45/18722 0.849255900196139 0.898671087423521 ACSS1 1 GO:0085029 extracellular matrix assembly 1/770 45/18722 0.849255900196139 0.898671087423521 PHLDB2 1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 1/770 45/18722 0.849255900196139 0.898671087423521 SLC25A5 1 GO:0044282 small molecule catabolic process 12/770 376/18722 0.852179559408014 0.901573406481982 KMO/ARG2/PNP/ABHD3/MTHFS/PPARD/IRS2/ACADVL/HIBADH/SYNJ1/AIG1/CDO1 12 GO:0006195 purine nucleotide catabolic process 1/770 46/18722 0.855470654002905 0.904095497114841 PNP 1 GO:0031294 lymphocyte costimulation 1/770 46/18722 0.855470654002905 0.904095497114841 CD274 1 GO:0032924 activin receptor signaling pathway 1/770 46/18722 0.855470654002905 0.904095497114841 DACT2 1 GO:0033047 regulation of mitotic sister chromatid segregation 1/770 46/18722 0.855470654002905 0.904095497114841 NUMA1 1 GO:0070828 heterochromatin organization 1/770 46/18722 0.855470654002905 0.904095497114841 MBD3 1 GO:0048285 organelle fission 16/770 488/18722 0.855827765649667 0.904207222721161 UBE2B/RAB11A/SPIRE2/GOLGA2/CCSAP/CHMP2B/NUMA1/VPS4B/HSPA1B/CALR/CHMP4B/SLC2A8/EML4/USP16/CHMP2A/UBE2I 16 GO:0008543 fibroblast growth factor receptor signaling pathway 2/770 82/18722 0.856302204298848 0.904207222721161 GATA3/CTNNB1 2 GO:0009205 purine ribonucleoside triphosphate metabolic process 2/770 82/18722 0.856302204298848 0.904207222721161 AK3/VCP 2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 2/770 82/18722 0.856302204298848 0.904207222721161 ERN1/AGO2 2 GO:0002449 lymphocyte mediated immunity 11/770 350/18722 0.856859861516623 0.904604383461299 PRKCZ/TFRC/GATA3/CD55/ARL8B/SERPINB9/PLEKHM2/CD46/SUPT6H/GNL1/HSPD1 11 GO:0051209 release of sequestered calcium ion into cytosol 3/770 115/18722 0.857085703901991 0.904645914992994 DDIT3/P2RY6/PDPK1 3 GO:0051607 defense response to virus 8/770 265/18722 0.857443840359605 0.904645914992994 PMAIP1/SERINC5/BCL2/IFI6/DHX36/IL10RB/TBK1/HSP90AA1 8 GO:0140546 defense response to symbiont 8/770 265/18722 0.857443840359605 0.904645914992994 PMAIP1/SERINC5/BCL2/IFI6/DHX36/IL10RB/TBK1/HSP90AA1 8 GO:0051302 regulation of cell division 5/770 177/18722 0.857777157471014 0.904806006705771 PGF/RAB11A/NCOA3/UVRAG/GAREM1 5 GO:0061053 somite development 2/770 83/18722 0.860922727149623 0.905591402703489 MIB1/RBBP6 2 GO:1901292 nucleoside phosphate catabolic process 2/770 83/18722 0.860922727149623 0.905591402703489 PNP/VCP 2 GO:0031123 RNA 3'-end processing 3/770 116/18722 0.861047366520567 0.905591402703489 PAPOLA/APP/DHX36 3 GO:0001754 eye photoreceptor cell differentiation 1/770 47/18722 0.861429510097238 0.905591402703489 RDH13 1 GO:0009261 ribonucleotide catabolic process 1/770 47/18722 0.861429510097238 0.905591402703489 PNP 1 GO:0010799 regulation of peptidyl-threonine phosphorylation 1/770 47/18722 0.861429510097238 0.905591402703489 APP 1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1/770 47/18722 0.861429510097238 0.905591402703489 HSPA1B 1 GO:0019884 antigen processing and presentation of exogenous antigen 1/770 47/18722 0.861429510097238 0.905591402703489 CTSL 1 GO:0032369 negative regulation of lipid transport 1/770 47/18722 0.861429510097238 0.905591402703489 IRS2 1 GO:0050798 activated T cell proliferation 1/770 47/18722 0.861429510097238 0.905591402703489 CD274 1 GO:0090279 regulation of calcium ion import 1/770 47/18722 0.861429510097238 0.905591402703489 CTNNB1 1 GO:0097028 dendritic cell differentiation 1/770 47/18722 0.861429510097238 0.905591402703489 CEBPB 1 GO:0097300 programmed necrotic cell death 1/770 47/18722 0.861429510097238 0.905591402703489 NUPR1 1 GO:0101023 vascular endothelial cell proliferation 1/770 47/18722 0.861429510097238 0.905591402703489 PDPK1 1 GO:1903170 negative regulation of calcium ion transmembrane transport 1/770 47/18722 0.861429510097238 0.905591402703489 UBQLN1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/770 47/18722 0.861429510097238 0.905591402703489 PDPK1 1 GO:0051259 protein complex oligomerization 7/770 238/18722 0.862993748241078 0.9070444732093 GOLGA2/EHD3/SLC9A1/KCNG1/MIF/USP16/CHMP2A 7 GO:0002715 regulation of natural killer cell mediated immunity 1/770 48/18722 0.867142992144099 0.909487166881508 SERPINB9 1 GO:0010569 regulation of double-strand break repair via homologous recombination 1/770 48/18722 0.867142992144099 0.909487166881508 PPP4R2 1 GO:0033628 regulation of cell adhesion mediated by integrin 1/770 48/18722 0.867142992144099 0.909487166881508 SERPINE1 1 GO:0035036 sperm-egg recognition 1/770 48/18722 0.867142992144099 0.909487166881508 SPESP1 1 GO:0044458 motile cilium assembly 1/770 48/18722 0.867142992144099 0.909487166881508 UBE2B 1 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 1/770 48/18722 0.867142992144099 0.909487166881508 ALYREF 1 GO:0048146 positive regulation of fibroblast proliferation 1/770 48/18722 0.867142992144099 0.909487166881508 MIF 1 GO:0090311 regulation of protein deacetylation 1/770 48/18722 0.867142992144099 0.909487166881508 BEX4 1 GO:0097720 calcineurin-mediated signaling 1/770 48/18722 0.867142992144099 0.909487166881508 SLC9A1 1 GO:1902003 regulation of amyloid-beta formation 1/770 48/18722 0.867142992144099 0.909487166881508 ABCG1 1 GO:0071346 cellular response to interferon-gamma 3/770 118/18722 0.868682452044339 0.910910071240939 SOCS1/CDC42EP4/STXBP3 3 GO:0002831 regulation of response to biotic stimulus 10/770 327/18722 0.869350911675996 0.911270926114125 CD55/ARG2/HEXIM1/SOCS1/CD274/SERPINB9/AKIRIN2/TBK1/HSP90AA1/HSPD1 10 GO:0001959 regulation of cytokine-mediated signaling pathway 4/770 150/18722 0.869693119736684 0.911270926114125 SOCS1/HSPA1B/TBK1/PAFAH1B1 4 GO:0009142 nucleoside triphosphate biosynthetic process 2/770 85/18722 0.869758082399915 0.911270926114125 AK3/VCP 2 GO:0097194 execution phase of apoptosis 2/770 85/18722 0.869758082399915 0.911270926114125 DEDD2/TAOK1 2 GO:0002764 immune response-regulating signaling pathway 15/770 468/18722 0.870973468683885 0.911778443611919 GATA3/VAV3/EZR/KCNN4/BCL2/LGR4/NFKBIA/TNFRSF21/PDPK1/DUSP3/DDX3X/HSPA1B/COLEC12/EIF2B2/HSPD1 15 GO:0006376 mRNA splice site selection 1/770 49/18722 0.872621191568381 0.911778443611919 SRSF5 1 GO:0006953 acute-phase response 1/770 49/18722 0.872621191568381 0.911778443611919 CEBPB 1 GO:0007602 phototransduction 1/770 49/18722 0.872621191568381 0.911778443611919 OPN3 1 GO:0008206 bile acid metabolic process 1/770 49/18722 0.872621191568381 0.911778443611919 OSBP 1 GO:0014075 response to amine 1/770 49/18722 0.872621191568381 0.911778443611919 SOD1 1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1/770 49/18722 0.872621191568381 0.911778443611919 SKP1 1 GO:0032692 negative regulation of interleukin-1 production 1/770 49/18722 0.872621191568381 0.911778443611919 ERRFI1 1 GO:0042461 photoreceptor cell development 1/770 49/18722 0.872621191568381 0.911778443611919 RDH13 1 GO:0045778 positive regulation of ossification 1/770 49/18722 0.872621191568381 0.911778443611919 TFAP2A 1 GO:0052372 modulation by symbiont of entry into host 1/770 49/18722 0.872621191568381 0.911778443611919 P4HB 1 GO:0070741 response to interleukin-6 1/770 49/18722 0.872621191568381 0.911778443611919 CEBPA 1 GO:1990573 potassium ion import across plasma membrane 1/770 49/18722 0.872621191568381 0.911778443611919 SLC12A4 1 GO:0009260 ribonucleotide biosynthetic process 5/770 182/18722 0.87341425150177 0.912415768392729 SLC26A2/AK3/ACSS1/VCP/SLC25A16 5 GO:0032413 negative regulation of ion transmembrane transporter activity 2/770 86/18722 0.873979632336854 0.912623744328278 NEDD4L/UBQLN1 2 GO:2001251 negative regulation of chromosome organization 2/770 86/18722 0.873979632336854 0.912623744328278 TNKS2/XRN1 2 GO:0006304 DNA modification 3/770 120/18722 0.875945087635001 0.914199597091119 GATA3/MBD3/TET2 3 GO:0071774 response to fibroblast growth factor 3/770 120/18722 0.875945087635001 0.914199597091119 GATA3/KDM5B/CTNNB1 3 GO:0090501 RNA phosphodiester bond hydrolysis 4/770 152/18722 0.876190342385808 0.914199597091119 ERN1/REXO2/XRN1/AGO2 4 GO:0006220 pyrimidine nucleotide metabolic process 1/770 50/18722 0.877873785286174 0.914199597091119 AK3 1 GO:0007140 male meiotic nuclear division 1/770 50/18722 0.877873785286174 0.914199597091119 SLC2A8 1 GO:0007632 visual behavior 1/770 50/18722 0.877873785286174 0.914199597091119 APP 1 GO:0015872 dopamine transport 1/770 50/18722 0.877873785286174 0.914199597091119 SYT7 1 GO:0038093 Fc receptor signaling pathway 1/770 50/18722 0.877873785286174 0.914199597091119 VAV3 1 GO:0045814 negative regulation of gene expression, epigenetic 1/770 50/18722 0.877873785286174 0.914199597091119 MBD3 1 GO:0051646 mitochondrion localization 1/770 50/18722 0.877873785286174 0.914199597091119 ARMCX3 1 GO:0060337 type I interferon signaling pathway 1/770 50/18722 0.877873785286174 0.914199597091119 TBK1 1 GO:0099054 presynapse assembly 1/770 50/18722 0.877873785286174 0.914199597091119 APP 1 GO:1901570 fatty acid derivative biosynthetic process 1/770 50/18722 0.877873785286174 0.914199597091119 FAR2 1 GO:0051262 protein tetramerization 2/770 87/18722 0.878074828394767 0.914217900102616 GOLGA2/USP16 2 GO:0001704 formation of primary germ layer 3/770 121/18722 0.879441159973141 0.915449195768991 DUSP5/ITGB4/CTNNB1 3 GO:0009144 purine nucleoside triphosphate metabolic process 2/770 88/18722 0.882046906138637 0.917526755506107 AK3/VCP 2 GO:0007369 gastrulation 5/770 185/18722 0.882078949461024 0.917526755506107 DUSP5/PHLDB2/ITGB4/CTNNB1/GPC3 5 GO:0140013 meiotic nuclear division 5/770 185/18722 0.882078949461024 0.917526755506107 UBE2B/SPIRE2/GOLGA2/CALR/SLC2A8 5 GO:0009584 detection of visible light 1/770 51/18722 0.882910052709569 0.917526755506107 OPN3 1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 1/770 51/18722 0.882910052709569 0.917526755506107 TANK 1 GO:0045668 negative regulation of osteoblast differentiation 1/770 51/18722 0.882910052709569 0.917526755506107 CRIM1 1 GO:0060043 regulation of cardiac muscle cell proliferation 1/770 51/18722 0.882910052709569 0.917526755506107 TGFBR3 1 GO:0060632 regulation of microtubule-based movement 1/770 51/18722 0.882910052709569 0.917526755506107 CCSAP 1 GO:0009199 ribonucleoside triphosphate metabolic process 2/770 89/18722 0.885899049116395 0.920249106055242 AK3/VCP 2 GO:0051781 positive regulation of cell division 2/770 89/18722 0.885899049116395 0.920249106055242 PGF/GAREM1 2 GO:0007129 homologous chromosome pairing at meiosis 1/770 52/18722 0.887738892054737 0.921391980651689 UBE2B 1 GO:0035176 social behavior 1/770 52/18722 0.887738892054737 0.921391980651689 CLN8 1 GO:0071357 cellular response to type I interferon 1/770 52/18722 0.887738892054737 0.921391980651689 TBK1 1 GO:0072523 purine-containing compound catabolic process 1/770 52/18722 0.887738892054737 0.921391980651689 PNP 1 GO:0045088 regulation of innate immune response 6/770 218/18722 0.888707345795988 0.922205061245607 HEXIM1/SOCS1/SERPINB9/AKIRIN2/TBK1/HSP90AA1 6 GO:0001909 leukocyte mediated cytotoxicity 3/770 124/18722 0.88940938617785 0.922741405647351 ARL8B/SERPINB9/PLEKHM2 3 GO:0001906 cell killing 5/770 188/18722 0.890232123865712 0.923402721320326 CD55/ARL8B/SERPINB9/PLEKHM2/CD59 5 GO:0060271 cilium assembly 10/770 337/18722 0.890991747302503 0.923998309429422 UBE2B/FHDC1/EHD3/ATP6V1D/ARF4/ATP6V0D1/LIMK2/DYNLL1/CDKL5/RP2 10 GO:0043113 receptor clustering 1/770 53/18722 0.892368835981778 0.924656666603702 RER1 1 GO:0045806 negative regulation of endocytosis 1/770 53/18722 0.892368835981778 0.924656666603702 LRPAP1 1 GO:0099172 presynapse organization 1/770 53/18722 0.892368835981778 0.924656666603702 APP 1 GO:2000772 regulation of cellular senescence 1/770 53/18722 0.892368835981778 0.924656666603702 ARG2 1 GO:0060294 cilium movement involved in cell motility 3/770 125/18722 0.892564556817021 0.924667190565326 UBE2B/CCSAP/DNAJA1 3 GO:0043488 regulation of mRNA stability 4/770 158/18722 0.89402612334087 0.925988811599991 DHX36/LARP4B/GIGYF2/AGO2 4 GO:0009150 purine ribonucleotide metabolic process 11/770 368/18722 0.89523308077949 0.927020446187687 SLC26A2/NUPR1/FAR2/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16 11 GO:0046390 ribose phosphate biosynthetic process 5/770 190/18722 0.895394221854573 0.927020446187687 SLC26A2/AK3/ACSS1/VCP/SLC25A16 5 GO:0006470 protein dephosphorylation 8/770 281/18722 0.895989869861782 0.927135808264818 PTPN21/DUSP5/BCL2/PTP4A1/DUSP3/PHLPP1/PPP4R2/PPP1CB 8 GO:0006497 protein lipidation 2/770 92/18722 0.896766900804566 0.927135808264818 ZDHHC3/ZDHHC20 2 GO:0032465 regulation of cytokinesis 2/770 92/18722 0.896766900804566 0.927135808264818 RAB11A/UVRAG 2 GO:0034502 protein localization to chromosome 2/770 92/18722 0.896766900804566 0.927135808264818 VCP/TNKS2 2 GO:1903351 cellular response to dopamine 2/770 92/18722 0.896766900804566 0.927135808264818 TGM2/GNAS 2 GO:0030834 regulation of actin filament depolymerization 1/770 54/18722 0.896808066593703 0.927135808264818 SCIN 1 GO:0051703 biological process involved in intraspecies interaction between organisms 1/770 54/18722 0.896808066593703 0.927135808264818 CLN8 1 GO:0006164 purine nucleotide biosynthetic process 5/770 191/18722 0.89789570028218 0.928067677765215 SLC26A2/AK3/ACSS1/VCP/SLC25A16 5 GO:0060402 calcium ion transport into cytosol 4/770 160/18722 0.899449532059134 0.929480924564634 BCL2/DDIT3/P2RY6/PDPK1 4 GO:1903350 response to dopamine 2/770 93/18722 0.900170061737466 0.930032638946256 TGM2/GNAS 2 GO:0046164 alcohol catabolic process 1/770 55/18722 0.901064429820769 0.930185219348848 SYNJ1 1 GO:0048016 inositol phosphate-mediated signaling 1/770 55/18722 0.901064429820769 0.930185219348848 SLC9A1 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/770 55/18722 0.901064429820769 0.930185219348848 ERBB3 1 GO:1902991 regulation of amyloid precursor protein catabolic process 1/770 55/18722 0.901064429820769 0.930185219348848 ABCG1 1 GO:0009165 nucleotide biosynthetic process 7/770 254/18722 0.901988948692621 0.930946754626207 SLC26A2/KMO/AK3/PNP/ACSS1/VCP/SLC25A16 7 GO:0006338 chromatin remodeling 7/770 255/18722 0.90407746139845 0.932715939989333 TOP1/GATA3/MBD3/HDAC5/BRD2/KDM5B/SUPT6H 7 GO:0051924 regulation of calcium ion transport 7/770 255/18722 0.90407746139845 0.932715939989333 BCL2/EHD3/P2RY6/PDPK1/CTNNB1/SLC9A1/UBQLN1 7 GO:0060759 regulation of response to cytokine stimulus 4/770 162/18722 0.904626901950948 0.933045050359933 SOCS1/HSPA1B/TBK1/PAFAH1B1 4 GO:0008037 cell recognition 6/770 225/18722 0.905010373039276 0.933045050359933 APP/TNFRSF21/BSG/COLEC12/NRP1/SPESP1 6 GO:0048255 mRNA stabilization 1/770 56/18722 0.905145449215315 0.933045050359933 LARP4B 1 GO:0050433 regulation of catecholamine secretion 1/770 56/18722 0.905145449215315 0.933045050359933 SYT7 1 GO:1901293 nucleoside phosphate biosynthetic process 7/770 256/18722 0.906127929449399 0.933864627186423 SLC26A2/KMO/AK3/PNP/ACSS1/VCP/SLC25A16 7 GO:0006956 complement activation 3/770 130/18722 0.90715968714005 0.934734640409196 CD55/CD46/CD59 3 GO:0006754 ATP biosynthetic process 1/770 57/18722 0.909058339181254 0.9359168810207 VCP 1 GO:0034205 amyloid-beta formation 1/770 57/18722 0.909058339181254 0.9359168810207 ABCG1 1 GO:0051785 positive regulation of nuclear division 1/770 57/18722 0.909058339181254 0.9359168810207 UBE2B 1 GO:0061756 leukocyte adhesion to vascular endothelial cell 1/770 57/18722 0.909058339181254 0.9359168810207 ST3GAL4 1 GO:0006637 acyl-CoA metabolic process 2/770 96/18722 0.909761899162964 0.936061024887271 FAR2/ACSS1 2 GO:0035383 thioester metabolic process 2/770 96/18722 0.909761899162964 0.936061024887271 FAR2/ACSS1 2 GO:0042158 lipoprotein biosynthetic process 2/770 96/18722 0.909761899162964 0.936061024887271 ZDHHC3/ZDHHC20 2 GO:0002763 positive regulation of myeloid leukocyte differentiation 1/770 58/18722 0.91281001766132 0.938035124356848 ID2 1 GO:0007131 reciprocal meiotic recombination 1/770 58/18722 0.91281001766132 0.938035124356848 UBE2B 1 GO:0010043 response to zinc ion 1/770 58/18722 0.91281001766132 0.938035124356848 GGH 1 GO:0034340 response to type I interferon 1/770 58/18722 0.91281001766132 0.938035124356848 TBK1 1 GO:0050432 catecholamine secretion 1/770 58/18722 0.91281001766132 0.938035124356848 SYT7 1 GO:0140527 reciprocal homologous recombination 1/770 58/18722 0.91281001766132 0.938035124356848 UBE2B 1 GO:0061013 regulation of mRNA catabolic process 4/770 166/18722 0.914278539060644 0.939350507245194 DHX36/LARP4B/GIGYF2/AGO2 4 GO:0002429 immune response-activating cell surface receptor signaling pathway 8/770 291/18722 0.91533115978989 0.940044346503096 GATA3/VAV3/EZR/KCNN4/BCL2/TNFRSF21/DUSP3/EIF2B2 8 GO:0002757 immune response-activating signal transduction 8/770 291/18722 0.91533115978989 0.940044346503096 GATA3/VAV3/EZR/KCNN4/BCL2/TNFRSF21/DUSP3/EIF2B2 8 GO:0030042 actin filament depolymerization 1/770 59/18722 0.916407118304311 0.940567800311098 SCIN 1 GO:0051353 positive regulation of oxidoreductase activity 1/770 59/18722 0.916407118304311 0.940567800311098 COX17 1 GO:2001258 negative regulation of cation channel activity 1/770 59/18722 0.916407118304311 0.940567800311098 UBQLN1 1 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3/770 134/18722 0.917516946022017 0.941512961702576 ARRDC3/ZDHHC3/ADM 3 GO:0021549 cerebellum development 2/770 99/18722 0.918485372223158 0.942312664152356 OPHN1/HSPA5 2 GO:0035825 homologous recombination 1/770 60/18722 0.919856002133582 0.943136308360419 UBE2B 1 GO:0051965 positive regulation of synapse assembly 1/770 60/18722 0.919856002133582 0.943136308360419 DLG5 1 GO:0060038 cardiac muscle cell proliferation 1/770 60/18722 0.919856002133582 0.943136308360419 TGFBR3 1 GO:0043487 regulation of RNA stability 4/770 170/18722 0.923049719842107 0.946069168223146 DHX36/LARP4B/GIGYF2/AGO2 4 GO:0043966 histone H3 acetylation 1/770 61/18722 0.923162768737222 0.946069168223146 GATA3 1 GO:0009259 ribonucleotide metabolic process 11/770 385/18722 0.923286045568766 0.946069168223146 SLC26A2/NUPR1/FAR2/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16 11 GO:0051963 regulation of synapse assembly 2/770 101/18722 0.923853776470441 0.946393027557553 APP/DLG5 2 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 10/770 356/18722 0.923981954458659 0.946393027557553 ANXA1/PRKCZ/TFRC/GATA3/CD55/CD274/CD46/SUPT6H/GNL1/HSPD1 10 GO:0007062 sister chromatid cohesion 1/770 62/18722 0.926333266999499 0.947517999620652 CTNNB1 1 GO:0009116 nucleoside metabolic process 1/770 62/18722 0.926333266999499 0.947517999620652 PNP 1 GO:0010573 vascular endothelial growth factor production 1/770 62/18722 0.926333266999499 0.947517999620652 ADGRG1 1 GO:0032615 interleukin-12 production 1/770 62/18722 0.926333266999499 0.947517999620652 HSPD1 1 GO:0032655 regulation of interleukin-12 production 1/770 62/18722 0.926333266999499 0.947517999620652 HSPD1 1 GO:0070265 necrotic cell death 1/770 62/18722 0.926333266999499 0.947517999620652 NUPR1 1 GO:1990542 mitochondrial transmembrane transport 2/770 102/18722 0.926411337377447 0.947517999620652 SLC25A5/HSPD1 2 GO:0001539 cilium or flagellum-dependent cell motility 3/770 138/18722 0.926810384091728 0.947537165352704 UBE2B/CCSAP/DNAJA1 3 GO:0060285 cilium-dependent cell motility 3/770 138/18722 0.926810384091728 0.947537165352704 UBE2B/CCSAP/DNAJA1 3 GO:0016311 dephosphorylation 12/770 417/18722 0.927081634230879 0.947620058127686 PTPN21/DUSP5/MTMR10/BCL2/PLPP3/PHOSPHO1/PTP4A1/DUSP3/SYNJ1/PHLPP1/PPP4R2/PPP1CB 12 GO:0001756 somitogenesis 1/770 63/18722 0.929373105392338 0.94937806153547 MIB1 1 GO:0045143 homologous chromosome segregation 1/770 63/18722 0.929373105392338 0.94937806153547 UBE2B 1 GO:1902373 negative regulation of mRNA catabolic process 1/770 63/18722 0.929373105392338 0.94937806153547 LARP4B 1 GO:0016064 immunoglobulin mediated immune response 5/770 207/18722 0.931391776111996 0.95124517736546 TFRC/CD55/CD46/SUPT6H/HSPD1 5 GO:0006940 regulation of smooth muscle contraction 1/770 64/18722 0.932287661844876 0.951575055094842 SOD1 1 GO:0046530 photoreceptor cell differentiation 1/770 64/18722 0.932287661844876 0.951575055094842 RDH13 1 GO:0070542 response to fatty acid 1/770 64/18722 0.932287661844876 0.951575055094842 LDLR 1 GO:0034341 response to interferon-gamma 3/770 141/18722 0.933139283066231 0.952249241761013 SOCS1/CDC42EP4/STXBP3 3 GO:0006816 calcium ion transport 12/770 422/18722 0.933506580373372 0.952429011056615 SLC3A2/KCNN4/BCL2/DDIT3/ANXA6/EHD3/P2RY6/TMEM37/PDPK1/CTNNB1/SLC9A1/UBQLN1 12 GO:0097553 calcium ion transmembrane import into cytosol 3/770 142/18722 0.935134316524896 0.953894431779644 DDIT3/P2RY6/PDPK1 3 GO:0019724 B cell mediated immunity 5/770 210/18722 0.936451180183818 0.955042208525576 TFRC/CD55/CD46/SUPT6H/HSPD1 5 GO:0032715 negative regulation of interleukin-6 production 1/770 66/18722 0.937761344332825 0.955648904550065 CD200 1 GO:0071300 cellular response to retinoic acid 1/770 66/18722 0.937761344332825 0.955648904550065 SERPINF1 1 GO:0006163 purine nucleotide metabolic process 11/770 396/18722 0.93781319350789 0.955648904550065 SLC26A2/NUPR1/FAR2/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16 11 GO:0019693 ribose phosphate metabolic process 11/770 396/18722 0.93781319350789 0.955648904550065 SLC26A2/NUPR1/FAR2/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16 11 GO:0032526 response to retinoic acid 2/770 107/18722 0.938027007257866 0.955671350882426 SYNJ1/SERPINF1 2 GO:0044782 cilium organization 10/770 368/18722 0.940090282653793 0.956453392772906 UBE2B/FHDC1/EHD3/ATP6V1D/ARF4/ATP6V0D1/LIMK2/DYNLL1/CDKL5/RP2 10 GO:0002832 negative regulation of response to biotic stimulus 2/770 108/18722 0.94013135032683 0.956453392772906 ARG2/SERPINB9 2 GO:0006958 complement activation, classical pathway 2/770 108/18722 0.94013135032683 0.956453392772906 CD55/CD46 2 GO:0098659 inorganic cation import across plasma membrane 2/770 108/18722 0.94013135032683 0.956453392772906 SLC12A4/SLC9A1 2 GO:0099587 inorganic ion import across plasma membrane 2/770 108/18722 0.94013135032683 0.956453392772906 SLC12A4/SLC9A1 2 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/770 67/18722 0.940330156771918 0.956453392772906 ANXA1 1 GO:0009583 detection of light stimulus 1/770 67/18722 0.940330156771918 0.956453392772906 OPN3 1 GO:0043967 histone H4 acetylation 1/770 67/18722 0.940330156771918 0.956453392772906 IWS1 1 GO:0032410 negative regulation of transporter activity 2/770 109/18722 0.942167725064437 0.958126892652263 NEDD4L/UBQLN1 2 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 1/770 68/18722 0.9427930771303 0.958176198927246 VCP 1 GO:0009988 cell-cell recognition 1/770 68/18722 0.9427930771303 0.958176198927246 SPESP1 1 GO:0031640 killing of cells of other organism 1/770 68/18722 0.9427930771303 0.958176198927246 SERPINB9 1 GO:0030317 flagellated sperm motility 2/770 110/18722 0.94413815328167 0.959151971009697 UBE2B/DNAJA1 2 GO:0097722 sperm motility 2/770 110/18722 0.94413815328167 0.959151971009697 UBE2B/DNAJA1 2 GO:0060401 cytosolic calcium ion transport 4/770 182/18722 0.944728388044236 0.959402057331257 BCL2/DDIT3/P2RY6/PDPK1 4 GO:0009145 purine nucleoside triphosphate biosynthetic process 1/770 69/18722 0.945154465069063 0.959402057331257 VCP 1 GO:0050688 regulation of defense response to virus 1/770 69/18722 0.945154465069063 0.959402057331257 HSP90AA1 1 GO:0070192 chromosome organization involved in meiotic cell cycle 1/770 69/18722 0.945154465069063 0.959402057331257 UBE2B 1 GO:0070588 calcium ion transmembrane transport 8/770 312/18722 0.946134295170044 0.960201057603326 DDIT3/ANXA6/EHD3/P2RY6/TMEM37/PDPK1/SLC9A1/UBQLN1 8 GO:0045123 cellular extravasation 1/770 70/18722 0.947418500982686 0.961308570636678 ST3GAL4 1 GO:0009141 nucleoside triphosphate metabolic process 2/770 112/18722 0.947889002846978 0.961590167179661 AK3/VCP 2 GO:0007389 pattern specification process 12/770 436/18722 0.948976930781017 0.962497872192512 TBX3/BASP1/HES1/DDIT3/GLI3/MIB1/BHLHE40/ADGRG1/CTNNB1/NRP1/GPC3/PBX1 12 GO:0045824 negative regulation of innate immune response 1/770 71/18722 0.949589193361162 0.962553272617372 SERPINB9 1 GO:0050795 regulation of behavior 1/770 71/18722 0.949589193361162 0.962553272617372 ARRDC3 1 GO:0002768 immune response-regulating cell surface receptor signaling pathway 8/770 315/18722 0.949611055225165 0.962553272617372 GATA3/VAV3/EZR/KCNN4/BCL2/TNFRSF21/DUSP3/EIF2B2 8 GO:0001707 mesoderm formation 1/770 72/18722 0.951670385850139 0.963660543119537 ITGB4 1 GO:0033045 regulation of sister chromatid segregation 1/770 72/18722 0.951670385850139 0.963660543119537 NUMA1 1 GO:0042273 ribosomal large subunit biogenesis 1/770 72/18722 0.951670385850139 0.963660543119537 DDX28 1 GO:0055021 regulation of cardiac muscle tissue growth 1/770 72/18722 0.951670385850139 0.963660543119537 TGFBR3 1 GO:1905818 regulation of chromosome separation 1/770 72/18722 0.951670385850139 0.963660543119537 NUMA1 1 GO:0050848 regulation of calcium-mediated signaling 1/770 73/18722 0.953665764021474 0.965155236485876 SLC9A1 1 GO:0051937 catecholamine transport 1/770 73/18722 0.953665764021474 0.965155236485876 SYT7 1 GO:0007338 single fertilization 3/770 153/18722 0.953727550563206 0.965155236485876 CD46/KDM5B/SPESP1 3 GO:0009201 ribonucleoside triphosphate biosynthetic process 1/770 74/18722 0.955578861866048 0.966636108136118 VCP 1 GO:1901568 fatty acid derivative metabolic process 1/770 74/18722 0.955578861866048 0.966636108136118 FAR2 1 GO:0071103 DNA conformation change 7/770 290/18722 0.95666761001914 0.967541039319134 ANXA1/HMGB3/TOP1/DHX36/BRD2/DDX3X/CHD2 7 GO:0072521 purine-containing compound metabolic process 11/770 416/18722 0.958208830012418 0.968903124990235 SLC26A2/NUPR1/FAR2/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16 11 GO:0006305 DNA alkylation 1/770 76/18722 0.95917163173688 0.969483213173403 MBD3 1 GO:0006306 DNA methylation 1/770 76/18722 0.95917163173688 0.969483213173403 MBD3 1 GO:0002455 humoral immune response mediated by circulating immunoglobulin 2/770 121/18722 0.961989123071494 0.972133806583909 CD55/CD46 2 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1/770 78/18722 0.962474166072892 0.972426757814522 GNAI1 1 GO:0000245 spliceosomal complex assembly 1/770 79/18722 0.9640239886498 0.973795162262711 SRSF5 1 GO:0007368 determination of left/right symmetry 2/770 124/18722 0.965815458505064 0.975407059126618 TBX3/MIB1 2 GO:0009117 nucleotide metabolic process 13/770 489/18722 0.96740871595365 0.976818162431011 SLC26A2/NUPR1/FAR2/KMO/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16/REXO2 13 GO:0001910 regulation of leukocyte mediated cytotoxicity 1/770 82/18722 0.968300313451565 0.977322354046819 SERPINB9 1 GO:0035082 axoneme assembly 1/770 82/18722 0.968300313451565 0.977322354046819 UBE2B 1 GO:0001510 RNA methylation 1/770 83/18722 0.969609796211345 0.978445851462359 RNMT 1 GO:0015844 monoamine transport 1/770 84/18722 0.970865252883766 0.979514386539746 SYT7 1 GO:0007127 meiosis I 2/770 129/18722 0.971383526833061 0.979838889516021 UBE2B/SLC2A8 2 GO:0006753 nucleoside phosphate metabolic process 13/770 497/18722 0.972203747247317 0.98046777424274 SLC26A2/NUPR1/FAR2/KMO/APP/AK3/PNP/MPP1/BPGM/ACSS1/VCP/SLC25A16/REXO2 13 GO:0050853 B cell receptor signaling pathway 2/770 131/18722 0.973356526971764 0.981431722764124 VAV3/BCL2 2 GO:0019932 second-messenger-mediated signaling 7/770 312/18722 0.974649326970711 0.982536434613606 UBE2B/EGFR/GNAI1/PDPK1/CAP2/SLC9A1/ADM 7 GO:0050829 defense response to Gram-negative bacterium 1/770 88/18722 0.975389990985889 0.983084208147793 SERPINE1 1 GO:0061982 meiosis I cell cycle process 2/770 135/18722 0.976915989373835 0.984280576056857 UBE2B/SLC2A8 2 GO:0003341 cilium movement 3/770 175/18722 0.976972050808191 0.984280576056857 UBE2B/CCSAP/DNAJA1 3 GO:0035278 miRNA mediated inhibition of translation 1/770 90/18722 0.977381905932374 0.984295480448872 AGO2 1 GO:0040033 negative regulation of translation, ncRNA-mediated 1/770 90/18722 0.977381905932374 0.984295480448872 AGO2 1 GO:0045974 regulation of translation, ncRNA-mediated 1/770 91/18722 0.9783166382441 0.984838749165727 AGO2 1 GO:0051983 regulation of chromosome segregation 1/770 91/18722 0.9783166382441 0.984838749165727 NUMA1 1 GO:0048525 negative regulation of viral process 1/770 92/18722 0.979212789204974 0.985342756181014 HEXIM1 1 GO:0070509 calcium ion import 1/770 92/18722 0.979212789204974 0.985342756181014 CTNNB1 1 GO:0002377 immunoglobulin production 4/770 216/18722 0.979414413175857 0.985346662801392 TFRC/DNAJB9/SUPT6H/HSPD1 4 GO:0051783 regulation of nuclear division 2/770 139/18722 0.980013426779432 0.985610196426407 UBE2B/CALR 2 GO:0045132 meiotic chromosome segregation 1/770 93/18722 0.980071949286142 0.985610196426407 UBE2B 1 GO:0051304 chromosome separation 1/770 96/18722 0.982442422756824 0.987595439297409 NUMA1 1 GO:0055017 cardiac muscle tissue growth 1/770 96/18722 0.982442422756824 0.987595439297409 TGFBR3 1 GO:0022613 ribonucleoprotein complex biogenesis 11/770 463/18722 0.984734806374106 0.989700189625286 EIF5/SBDS/DDX28/EIF2S2/SRSF5/DDX3X/EIF4A3/EIF4H/AGO2/HSP90AA1/EIF3J 11 GO:0006910 phagocytosis, recognition 1/770 100/18722 0.985170829154719 0.98993874605323 COLEC12 1 GO:0050830 defense response to Gram-positive bacterium 1/770 101/18722 0.985783999681562 0.990269996143706 TBK1 1 GO:0009566 fertilization 3/770 190/18722 0.985897943180599 0.990269996143706 CD46/KDM5B/SPESP1 3 GO:0007218 neuropeptide signaling pathway 1/770 106/18722 0.988490270632432 0.992600351138366 NPB 1 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 5/770 273/18722 0.988769017372064 0.992600351138366 CLDN7/TENM3/CD164/BSG/CLDN4 5 GO:0016072 rRNA metabolic process 4/770 236/18722 0.988815601655799 0.992600351138366 SBDS/DEDD2/XRN1/EIF4A3 4 GO:0065004 protein-DNA complex assembly 3/770 201/18722 0.990221317607807 0.993734613773596 GTF2B/BRD2/PSMC6 3 GO:0071824 protein-DNA complex subunit organization 4/770 241/18722 0.990425547365389 0.993734613773596 GTF2B/BRD2/SUPT6H/PSMC6 4 GO:0019722 calcium-mediated signaling 3/770 202/18722 0.990543814291281 0.993734613773596 EGFR/PDPK1/SLC9A1 3 GO:0006959 humoral immune response 6/770 317/18722 0.991056133806384 0.994048453050968 GATA3/CD55/BCL2/TNFRSF21/CD46/CD59 6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 2/770 167/18722 0.992829718710472 0.995226410849785 TENM3/BSG 2 GO:0009451 RNA modification 2/770 167/18722 0.992829718710472 0.995226410849785 RBM47/RNMT 2 GO:0034728 nucleosome organization 2/770 167/18722 0.992829718710472 0.995226410849785 BRD2/SUPT6H 2 GO:0090305 nucleic acid phosphodiester bond hydrolysis 4/770 261/18722 0.994911761540594 0.997058942382201 ERN1/REXO2/XRN1/AGO2 4 GO:0006333 chromatin assembly or disassembly 2/770 177/18722 0.995058021365982 0.997058942382201 TLK1/BRD2 2 GO:0007416 synapse assembly 2/770 179/18722 0.995414061694379 0.99721517278309 APP/DLG5 2 GO:0006334 nucleosome assembly 1/770 129/18722 0.995646243254797 0.99724728243993 BRD2 1 GO:0042742 defense response to bacterium 6/770 350/18722 0.996530279303618 0.997932150677236 CEBPB/ARG2/SERPINE1/RAB1A/COLEC12/TBK1 6 GO:0006261 DNA-dependent DNA replication 1/770 151/18722 0.998283988079383 0.999286683929201 ALYREF 1 GO:0031497 chromatin assembly 1/770 151/18722 0.998283988079383 0.999286683929201 BRD2 1 GO:0042254 ribosome biogenesis 4/770 299/18722 0.99852995636763 0.999332149544065 SBDS/DDX28/DDX3X/EIF4A3 4 GO:0006364 rRNA processing 2/770 225/18722 0.999199837086804 0.999801764699507 SBDS/EIF4A3 2 GO:0006323 DNA packaging 1/770 199/18722 0.999775810871537 0.999949753449648 BRD2 1 GO:0034470 ncRNA processing 4/770 395/18722 0.999946641268794 0.999949753449648 SBDS/DDX3X/EIF4A3/AGO2 4 GO:0034660 ncRNA metabolic process 6/770 485/18722 0.999949753449648 0.999949753449648 SBDS/DEDD2/XRN1/DDX3X/EIF4A3/AGO2 6