ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	106/735	182/18367	7.08176690573681e-101	4.72353852612645e-98	RPLP0/RPL35/RPS10/RPL8/RPSA/RPL14/RPL7A/RPL23A/RPS5/RPS3/RPS3A/RPS2/RPL3/RPS16/RPL15/RPS6/RPS12/RPL18A/RPS19/RPL27A/RPL6/RPL10A/RPS8/RPL26/RPL29/RPS13/RPS23/RPL13A/RPL32/RPS15/RPL22/RPS4X/RPL24/RPS25/RPL13/RPLP1/RPL11/RPL21/RPS14/RPS18/RPS7/RPL18/RPS27A/RPS15A/RPL9/RPL19/RPL12/RPS24/RPL41/RPL27/RPL28/RPL37/RPL31/RPL5/UBA52/RPS20/RPL10/RPL7/RPLP2/RPS26/RPL35A/RPL30/RPL36A/RPL36/RPS17/RPL34/MRPL51/RPL37A/RPS28/RPL23/RPL4/MRPL11/MRPL27/RPS29/RPS4Y1/RPS9/RPS11/RPL36AL/MRPS15/RPL17/MRPL17/MRPS7/MRPL57/MRPS21/MRPS6/MRPL14/MRPS34/MRPL12/MRPL37/MRPL20/MRPL22/MRPL16/MRPL52/MRPS25/MRPS16/MRPL4/MRPL13/MRPS18C/MRPL18/MRPS33/MRPS12/MRPL46/MRPL21/MRPS14/RPL26L1/RPL22L1	106
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	31/735	72/18367	1.18718534908321e-24	3.95926313919252e-22	UQCRH/COX5A/UQCR10/COX8A/NDUFS5/NDUFA4/CYB5A/NDUFA6/NDUFS6/COX4I1/NDUFB2/COX5B/COX7B/COX6B1/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/UQCRFS1/NDUFB7/NDUFA2/NDUFA10/CYC1/NDUFV1/NDUFB8/NDUFS3	31
GO:0009055	electron transfer activity	38/735	126/18367	2.64939342921319e-23	5.89048472428399e-21	UQCRH/COX5A/UQCR10/COX8A/NDUFS5/NDUFA4/CYB5A/ETFB/NDUFA6/AKR7A2/NDUFS6/COX4I1/NDUFB2/COX5B/COX7B/COX6B1/COX7A2/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/AKR1B1/ADH5/NDUFA12/NDUFB1/NDUFA13/UQCRFS1/NDUFB7/CYCS/ETFA/NDUFA2/NDUFA10/CYC1/NDUFV1/NDUFB8/NDUFS3	38
GO:0019843	rRNA binding	29/735	68/18367	5.34106015265196e-23	8.90621780454714e-21	RPLP0/NPM1/RPL8/RPL23A/RPS5/RPS3/RPS13/RPS4X/RPL11/RPS14/RPS18/RPL9/RPL19/RPL12/RPL37/RPL5/RPL23/MRPL11/RPS4Y1/RPS9/RPS11/MRPS7/MRPS6/MRPL20/MRPL16/MRPS18C/MRPL18/BRIX1/IMP3	29
GO:0008137	NADH dehydrogenase (ubiquinone) activity	20/735	42/18367	1.93095390140215e-17	2.57589250447046e-15	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	20
GO:0050136	NADH dehydrogenase (quinone) activity	20/735	43/18367	3.4761714993047e-17	3.86434398339372e-15	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	20
GO:0003954	NADH dehydrogenase activity	20/735	45/18367	1.06363989244848e-16	8.86809760328921e-15	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	20
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	20/735	45/18367	1.06363989244848e-16	8.86809760328921e-15	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	20
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	21/735	57/18367	1.83761293423274e-15	1.36187536348138e-13	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/DCXR/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	21
GO:0045296	cadherin binding	44/735	332/18367	2.75852108437305e-12	1.83993356327682e-10	RANBP1/RAN/LDHA/ENO1/RPL14/RPL7A/RPL23A/PFN1/RPS2/RPL15/RPL6/RPL29/RPL24/PRDX1/ALDOA/CCNB2/RPS26/TAGLN2/PDLIM1/RPL34/PARK7/PKM/ANXA2/KRT18/PRDX6/S100A11/CTNNAL1/PAICS/PSMB6/EEF1D/TMPO/HSP90AB1/YWHAE/PPP1CA/SERBP1/NUDC/DIAPH3/CCT8/OLA1/CNN3/ATIC/AHSA1/NOP56/RUVBL1	44
GO:0015399	primary active transmembrane transporter activity	31/735	181/18367	6.60266643982247e-12	4.0036168321469e-10	UQCRH/COX5A/UQCR10/COX8A/NDUFS5/NDUFA4/CYB5A/NDUFA6/NDUFS6/COX4I1/NDUFB2/COX5B/COX7B/COX6B1/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/UQCRFS1/NDUFB7/NDUFA2/NDUFA10/CYC1/NDUFV1/NDUFB8/NDUFS3	31
GO:0016651	oxidoreductase activity, acting on NAD(P)H	21/735	88/18367	2.65861838892656e-11	1.47774872117835e-09	NDUFS5/NDUFA4/NDUFA6/NDUFS6/NDUFB2/NDUFB4/NDUFB10/DCXR/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/NDUFB7/NDUFA2/NDUFA10/NDUFV1/NDUFB8/NDUFS3	21
GO:0051082	unfolded protein binding	24/735	122/18367	8.1369346055032e-11	4.17487337066972e-09	TUBB4B/PPIA/NPM1/HSPE1/PTGES3/NACA/CCT5/HSP90AB1/HSPD1/HSP90AA1/CCT2/NUDC/CCT8/CCT3/CCT7/PFDN2/MKKS/CCT6A/CCT4/PFDN4/VBP1/TCP1/PFDN1/TTC1	24
GO:0003697	single-stranded DNA binding	23/735	123/18367	5.81093010767415e-10	2.76849312987047e-08	HMGB2/HMGB1/RPA3/HNRNPA1/RAD51/RAD51AP1/YBX1/MCM7/NME1/NUCKS1/SSBP1/MCM5/HNRNPA2B1/RPA2/HSPD1/POLR2H/MCM4/MCM3/SUB1/SMC2/POLR2G/SMC4/RAD23A	23
GO:0043021	ribonucleoprotein complex binding	24/735	149/18367	5.6589754165667e-09	2.51635773523333e-07	SNRPD1/SNRPG/NPM1/RPSA/RPLP1/SNRPD2/SNRPB/NME1/SNRPC/UNG/PPP1CA/SRP9/C1QBP/SERBP1/EIF5A/CSNK2B/EIF3K/EZH2/OLA1/EIF6/PPIH/RBM3/CBX5/NAA10	24
GO:0004298	threonine-type endopeptidase activity	8/735	14/18367	1.53579362050005e-08	6.40233965545957e-07	PSMB2/PSMB1/PSMB6/PSMB3/PSMB5/PSMB7/PSMA4/PSMB4	8
GO:0055106	ubiquitin-protein transferase regulator activity	9/735	22/18367	7.80309077513921e-08	3.06156561589286e-06	RPS15/RPL11/RPS7/RPL37/RPL5/RPS20/CDC20/RPL23/UBE2L3	9
GO:0044389	ubiquitin-like protein ligase binding	34/735	316/18367	1.69016310064926e-07	6.26299326740588e-06	TUBA1B/TUBB/UBE2C/UBE2T/SLC25A5/TPI1/RPL11/RPS27A/RPL5/UBA52/PA2G4/ACTG1/CCNB1/CACYBP/RPL23/PRDX6/AURKA/UBB/NEDD8/RBX1/HSP90AB1/RPA2/SUMO2/UBE2L3/YWHAE/UBE2N/HSPD1/PSMA3/HSP90AA1/CCT2/BAG2/SUMO1/NAE1/TCP1	34
GO:0031386	protein tag	7/735	13/18367	2.22035969584947e-07	7.79463114279788e-06	RPS27A/UBA52/UBB/NEDD8/SUMO2/UBL5/SUMO1	7
GO:0044183	protein folding chaperone	11/735	40/18367	3.12628759820499e-07	1.04261691400137e-05	CCT5/HSP90AB1/CCT2/CCT8/CCT3/CCT7/PFDN2/CCT6A/CCT4/TCP1/PFDN1	11
GO:0031625	ubiquitin protein ligase binding	32/735	297/18367	3.77233939789054e-07	1.1981668468538e-05	TUBA1B/TUBB/UBE2T/SLC25A5/TPI1/RPL11/RPS27A/RPL5/UBA52/PA2G4/ACTG1/CACYBP/RPL23/PRDX6/AURKA/UBB/NEDD8/RBX1/HSP90AB1/RPA2/SUMO2/UBE2L3/YWHAE/UBE2N/HSPD1/PSMA3/HSP90AA1/CCT2/BAG2/SUMO1/NAE1/TCP1	32
GO:0048027	mRNA 5'-UTR binding	9/735	27/18367	6.13950442349425e-07	1.8613861138503e-05	RPS3A/RPL26/RPS13/RPS14/RPS7/RPL41/RPL5/CCT5/NCL	9
GO:0045182	translation regulator activity	20/735	140/18367	7.73752109297462e-07	2.22752906854099e-05	TYMS/RPL22/RPS14/EEF1A1/EEF1B2/RPL10/DHFR/RPS9/EIF3F/EIF2S2/EEF1D/EIF5A/EIF3K/EIF3H/EIF6/EIF3I/EIF3M/EIF1AX/EIF3L/MCTS1	20
GO:0140678	molecular function inhibitor activity	19/735	128/18367	8.01509709819845e-07	2.22752906854099e-05	CALM2/RPS15/RPL11/RPS7/ANXA5/RPL37/RPL5/RPS20/PHPT1/CALM1/DYNLL1/ANXA2/RPL23/ANXA3/CAV1/MDFI/ID1/ENSA/ID3	19
GO:0140097	catalytic activity, acting on DNA	26/735	229/18367	1.74310467122837e-06	4.65060326283729e-05	PCNA/TOP2A/RPS3/RAD51/RFC2/FEN1/PTGES3/MCM7/RFC4/NME1/RFC3/HELLS/RAD51C/MCM5/UNG/XRCC6/MCM4/MCM3/APEX1/POLD3/DNMT1/RUVBL1/POLE4/POLE3/SMC3/RFC1	26
GO:0017116	single-stranded DNA helicase activity	8/735	23/18367	1.8188242284745e-06	4.66598369381728e-05	RAD51/RFC2/MCM7/RFC4/RFC3/MCM5/MCM4/MCM3	8
GO:0070003	threonine-type peptidase activity	8/735	24/18367	2.63281976626106e-06	6.50403994109676e-05	PSMB2/PSMB1/PSMB6/PSMB3/PSMB5/PSMB7/PSMA4/PSMB4	8
GO:0004129	cytochrome-c oxidase activity	7/735	19/18367	5.28016954536953e-06	0.000125781181670053	COX5A/COX8A/CYB5A/COX4I1/COX5B/COX7B/COX6B1	7
GO:0008135	translation factor activity, RNA binding	14/735	84/18367	5.63614115850753e-06	0.000129631246645673	EEF1A1/EEF1B2/EIF3F/EIF2S2/EEF1D/EIF5A/EIF3K/EIF3H/EIF6/EIF3I/EIF3M/EIF1AX/EIF3L/MCTS1	14
GO:0090079	translation regulator activity, nucleic acid binding	16/735	108/18367	6.02344292754052e-06	0.000133921214422318	TYMS/EEF1A1/EEF1B2/DHFR/EIF3F/EIF2S2/EEF1D/EIF5A/EIF3K/EIF3H/EIF6/EIF3I/EIF3M/EIF1AX/EIF3L/MCTS1	16
GO:0016675	oxidoreductase activity, acting on a heme group of donors	7/735	20/18367	7.84333444647601e-06	0.000168758195993532	COX5A/COX8A/CYB5A/COX4I1/COX5B/COX7B/COX6B1	7
GO:0070182	DNA polymerase binding	7/735	22/18367	1.60872753944148e-05	0.000335319146502334	PCNA/HMGB1/RAD51/CDT1/PTGES3/HSP90AB1/HSP90AA1	7
GO:0022804	active transmembrane transporter activity	35/735	406/18367	1.79801601880703e-05	0.000353810283709004	SLC25A5/UQCRH/SLC25A6/SLC25A3/COX5A/UQCR10/COX8A/NDUFS5/NDUFA4/CYB5A/NDUFA6/NDUFS6/COX4I1/NDUFB2/COX5B/COX7B/COX6B1/NDUFB4/NDUFB10/NDUFV2/NDUFS8/NDUFB6/NDUFB3/NDUFA12/NDUFB1/NDUFA13/UQCRFS1/NDUFB7/NDUFA2/NDUFA10/CYC1/NDUFV1/NDUFB8/SLC25A1/NDUFS3	35
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	9/735	39/18367	1.80353068157513e-05	0.000353810283709004	POLR2L/POLR2H/POLR3K/POLR2I/POLR2J/POLR2E/POLR2G/POLR2K/POLR2F	9
GO:0017070	U6 snRNA binding	6/735	16/18367	2.28348654402417e-05	0.00043516729281832	LSM3/LSM4/LSM2/LSM7/EIF5A/LSM8	6
GO:0003743	translation initiation factor activity	10/735	51/18367	2.85756881334804e-05	0.000529443999584206	EIF3F/EIF2S2/EIF3K/EIF3H/EIF6/EIF3I/EIF3M/EIF1AX/EIF3L/MCTS1	10
GO:0008094	ATP-dependent activity, acting on DNA	15/735	111/18367	3.58021076981548e-05	0.000645405563099169	TOP2A/RAD51/RFC2/MCM7/RFC4/RFC3/HELLS/RAD51C/MCM5/XRCC6/MCM4/MCM3/RUVBL1/SMC3/RFC1	15
GO:0017069	snRNA binding	10/735	53/18367	4.05693452472197e-05	0.000693445807676178	LSM3/LSM4/SNRPD3/LSM2/LSM7/SNU13/SNRPA1/EIF5A/SNRPA/LSM8	10
GO:0034062	5'-3' RNA polymerase activity	9/735	43/18367	4.15859554828293e-05	0.000693445807676178	POLR2L/POLR2H/POLR3K/POLR2I/POLR2J/POLR2E/POLR2G/POLR2K/POLR2F	9
GO:0097747	RNA polymerase activity	9/735	43/18367	4.15859554828293e-05	0.000693445807676178	POLR2L/POLR2H/POLR3K/POLR2I/POLR2J/POLR2E/POLR2G/POLR2K/POLR2F	9
GO:0098641	cadherin binding involved in cell-cell adhesion	6/735	18/18367	4.94196789577963e-05	0.000803973801581711	PDLIM1/ANXA2/KRT18/S100A11/PPP1CA/CNN3	6
GO:0016853	isomerase activity	18/735	158/18367	6.37408389151868e-05	0.00101226522753404	PPIA/TOP2A/TPI1/MIF/PTGES3/PGAM1/ECH1/ECI1/FKBP3/HSPD1/ISYNA1/DDT/PPIF/PPIL1/PPIH/PPIC/PIN1/PIN4	18
GO:0000217	DNA secondary structure binding	8/735	36/18367	7.07570298224028e-05	0.00109755671840797	HMGB2/HMGB1/HMGA1/RAD51AP1/CLSPN/RAD51C/HNRNPD/HMGB3	8
GO:0003684	damaged DNA binding	11/735	68/18367	7.47414116413807e-05	0.00113301185374548	HMGB2/PCNA/HMGB1/RPA3/RPS3/FEN1/RPA2/UNG/XRCC6/APEX1/RAD23A	11
GO:0004857	enzyme inhibitor activity	11/735	70/18367	9.81114857692399e-05	0.00145423024462407	RPS15/RPL11/RPS7/ANXA5/RPL37/RPL5/RPS20/DYNLL1/ANXA2/RPL23/ANXA3	11
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	8/735	38/18367	0.00010654054591226	0.00154483791572778	PPIA/FKBP3/PPIF/PPIL1/PPIH/PPIC/PIN1/PIN4	8
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	9/735	50/18367	0.000143863440181221	0.00204163648086967	CKS1B/CCNA2/CCNB2/CKS2/CCNB1/CCNE1/CDKN2A/CCND1/CDK4	9
GO:0016209	antioxidant activity	12/735	86/18367	0.000155762922464681	0.00216445561008213	GSTO1/PRDX2/GSTP1/PRDX1/TXN/SOD1/PARK7/PRDX6/PRDX5/GPX4/PRDX3/TXNDC17	12
GO:0016859	cis-trans isomerase activity	8/735	41/18367	0.000187230046179148	0.00254862124084677	PPIA/FKBP3/PPIF/PPIL1/PPIH/PPIC/PIN1/PIN4	8
GO:0008022	protein C-terminus binding	19/735	189/18367	0.000215535857809962	0.00287524834318489	PCNA/TOP2A/MAD2L1/RAD51/CDC20/DYNLT1/BANF1/PRDX3/XRCC6/ITGB3BP/NCL/YWHAQ/PHB/SAE1/PHB2/YEATS4/HRAS/ID1/STIP1	19
GO:0030515	snoRNA binding	7/735	32/18367	0.000223916403674981	0.00292847531865123	NHP2/SNU13/NUDT1/NUDT5/NOP10/NOP56/IMP3	7
GO:0016779	nucleotidyltransferase activity	15/735	132/18367	0.000261309544591181	0.00335179742773688	POLR2L/PTGES3/POLR2H/POLR3K/POLR2I/POLR2J/POLR2E/UGP2/NUDT5/POLR2G/POLD3/POLR2K/POLR2F/POLE4/POLE3	15
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	9/735	55/18367	0.000305493655414256	0.00384460883323225	PRDX2/GSTP1/PRDX1/PARK7/PRDX6/PRDX5/GPX4/PRDX3/TXNDC17	9
GO:0051087	chaperone binding	13/735	107/18367	0.00034376046032536	0.0041991922125331	BIRC5/HSPE1/DNAJC9/PTGES3/SOD1/HSPD1/BAG2/TBCA/TIMM10/PFDN4/AHSA1/BAX/STIP1	13
GO:0051536	iron-sulfur cluster binding	10/735	68/18367	0.000352555867918821	0.0041991922125331	RPS3/NDUFV2/NDUFS8/NFU1/UQCRFS1/CISD1/GLRX3/NUBP2/NDUFV1/ISCU	10
GO:0051540	metal cluster binding	10/735	68/18367	0.000352555867918821	0.0041991922125331	RPS3/NDUFV2/NDUFS8/NFU1/UQCRFS1/CISD1/GLRX3/NUBP2/NDUFV1/ISCU	10
GO:0042162	telomeric DNA binding	7/735	36/18367	0.00048323637796486	0.00555721834659589	HNRNPA1/HNRNPA2B1/RPA2/HNRNPD/XRCC6/NCL/APEX1	7
GO:0097718	disordered domain specific binding	7/735	36/18367	0.00048323637796486	0.00555721834659589	GAPDH/CALM2/RRM1/CALM1/HSP90AB1/HSP90AA1/PPIL1	7
GO:0008301	DNA binding, bending	5/735	18/18367	0.000561484499743015	0.00618111743458866	HMGB2/HMGB1/TOP2A/HMGB3/TFAM	5
GO:0003678	DNA helicase activity	10/735	72/18367	0.000563298478631003	0.00618111743458866	RAD51/RFC2/MCM7/RFC4/RFC3/MCM5/XRCC6/MCM4/MCM3/RUVBL1	10
GO:0019887	protein kinase regulator activity	19/735	204/18367	0.00056528960046463	0.00618111743458866	HMGB1/CKS1B/CALM2/NPM1/RPLP1/CCNA2/CCNB2/CALM1/CKS2/CCNB1/TPX2/CCNE1/HSP90AB1/CD24/CSNK2B/PKIB/CDKN2A/CCND1/CDK4	19
GO:0047429	nucleoside-triphosphate diphosphatase activity	4/735	11/18367	0.000670058982484125	0.00709411652883986	DUT/DCTPP1/NUDT1/NUDT15	4
GO:1990226	histone methyltransferase binding	4/735	11/18367	0.000670058982484125	0.00709411652883986	HSP90AB1/CBX3/CBX1/NOP56	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	7/735	39/18367	0.000802384948054241	0.00836235563050279	UBE2C/UBE2T/UBE2S/UBE2L3/UBE2N/UBE2I/UFC1	7
GO:0004601	peroxidase activity	8/735	51/18367	0.000877508053743112	0.0090045826437947	PRDX2/GSTP1/PRDX1/PRDX6/PRDX5/GPX4/PRDX3/TXNDC17	8
GO:0016829	lyase activity	18/735	196/18367	0.000920005186424266	0.00929762817189372	HMGB1/GGCT/ENO1/TPI1/RPS3/ALDOA/PARK7/ECHS1/PAICS/ECI1/XRCC6/TSEN34/GLO1/DDT/FH/PCBD1/PTS/UMPS	18
GO:0016018	cyclosporin A binding	5/735	20/18367	0.000950671704241554	0.00946414965267338	PPIA/PPIF/PPIL1/PPIH/PPIC	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	14/735	136/18367	0.0011158331184683	0.0109450101473288	LDHA/LDHB/AKR7A2/IDH2/MDH1/IMPDH2/MDH2/DCXR/AKR1B1/ADH5/HADH/GRHPR/VKORC1/HSD17B10	14
GO:0019207	kinase regulator activity	20/735	233/18367	0.00114272565364882	0.0110463479852719	HMGB1/CKS1B/CALM2/GSTP1/NPM1/RPLP1/CCNA2/CCNB2/CALM1/CKS2/CCNB1/TPX2/CCNE1/HSP90AB1/CD24/CSNK2B/PKIB/CDKN2A/CCND1/CDK4	20
GO:0016835	carbon-oxygen lyase activity	10/735	79/18367	0.00117809746535911	0.0112255858484932	ENO1/TPI1/RPS3/PARK7/ECHS1/ECI1/XRCC6/FH/PCBD1/PTS	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	13/735	124/18367	0.00140133803844122	0.0131646826991591	LDHA/LDHB/AKR7A2/IDH2/MDH1/IMPDH2/MDH2/DCXR/AKR1B1/ADH5/HADH/GRHPR/HSD17B10	13
GO:0051287	NAD binding	8/735	56/18367	0.00164281925827264	0.0152188950731646	GAPDH/LDHA/IDH2/MDH1/HADH/PARP1/GRHPR/NDUFV1	8
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4/735	14/18367	0.00184642686144529	0.0166427934673515	MIF/ECH1/ECI1/DDT	4
GO:0043023	ribosomal large subunit binding	4/735	14/18367	0.00184642686144529	0.0166427934673515	NPM1/OLA1/EIF6/RBM3	4
GO:0015078	proton transmembrane transporter activity	13/735	130/18367	0.00214874453645937	0.019109501410912	SLC25A5/UQCRH/SLC25A3/COX5A/UQCR10/COX8A/CYB5A/COX4I1/COX5B/COX7B/COX6B1/UQCRFS1/CYC1	13
GO:1990825	sequence-specific mRNA binding	4/735	15/18367	0.00243876846742214	0.0214034022075075	TYMS/DHFR/SRSF3/SSB	4
GO:0035173	histone kinase activity	4/735	16/18367	0.00314970265980704	0.0272837879752116	CDK1/AURKB/AURKA/VRK1	4
GO:0000400	four-way junction DNA binding	4/735	17/18367	0.00398984370228701	0.0336864018914612	HMGB2/HMGB1/RAD51C/HMGB3	4
GO:0070628	proteasome binding	4/735	17/18367	0.00398984370228701	0.0336864018914612	PSMG1/PSMD14/RAD23A/ID1	4
GO:0003713	transcription coactivator activity	20/735	262/18367	0.00448069711402865	0.0372323035855298	HMGB2/HMGB1/NPM1/PAGE4/HMGA1/VGLL1/PDLIM1/NUCKS1/PARK7/EDF1/UBE2L3/ENY2/SUB1/ACTL6A/APEX1/PMF1/TAF9/PCBD1/RUVBL1/BUD31	20
GO:0003712	transcription coregulator activity	32/735	489/18367	0.00454872592617293	0.0372323035855298	HMGB2/HMGB1/GMNN/NPM1/PAGE4/HMGA1/VGLL1/PA2G4/PDLIM1/NUCKS1/PARK7/EDF1/UBE2L3/PSIP1/HSBP1/SAP18/C1QBP/ENY2/EZH2/SUB1/ACTL6A/APEX1/PHB/CCND1/PMF1/UXT/TAF9/RALY/PCBD1/PIR/RUVBL1/BUD31	32
GO:0047485	protein N-terminus binding	11/735	110/18367	0.00457728469867083	0.0372323035855298	CALM2/NPM1/ZWINT/CALM1/BANF1/RPA2/EIF5A/YWHAQ/PARP1/PHB2/ID1	11
GO:0043022	ribosome binding	8/735	66/18367	0.00468550356488415	0.0376533840696112	RPSA/C1QBP/SERBP1/EIF5A/EIF3K/OLA1/EIF6/NAA10	8
GO:0070122	isopeptidase activity	4/735	18/18367	0.00496937490301387	0.0394592030989316	EIF3F/PSMD14/PSMD7/EIF3H	4
GO:0003746	translation elongation factor activity	4/735	19/18367	0.00609798446393201	0.0454580726141498	EEF1A1/EEF1B2/EEF1D/EIF5A	4
GO:0019205	nucleobase-containing compound kinase activity	6/735	42/18367	0.00617477785387326	0.0454580726141498	TK1/DTYMK/NME1/NME4/AK2/ADK	6
GO:0001094	TFIID-class transcription factor complex binding	3/735	10/18367	0.00620192594885702	0.0454580726141498	EDF1/FBL/RUVBL1	3
GO:0004523	RNA-DNA hybrid ribonuclease activity	3/735	10/18367	0.00620192594885702	0.0454580726141498	FEN1/RNASEH2A/APEX1	3
GO:0008097	5S rRNA binding	3/735	10/18367	0.00620192594885702	0.0454580726141498	RPL11/RPL5/MRPL18	3
GO:0050786	RAGE receptor binding	3/735	10/18367	0.00620192594885702	0.0454580726141498	HMGB2/HMGB1/S100A13	3
GO:0098505	G-rich strand telomeric DNA binding	3/735	10/18367	0.00620192594885702	0.0454580726141498	HNRNPA1/HNRNPA2B1/RPA2	3
GO:0005200	structural constituent of cytoskeleton	10/735	103/18367	0.00822020084980618	0.0587270514133156	TUBA1B/TUBB/TUBA1C/TUBB4B/ACTG1/KRT19/TUBB6/TUBG1/ARPC5/YEATS4	10
GO:0019855	calcium channel inhibitor activity	3/735	11/18367	0.00827637606124687	0.0587270514133156	CALM2/PHPT1/CALM1	3
GO:0097371	MDM2/MDM4 family protein binding	3/735	11/18367	0.00827637606124687	0.0587270514133156	RPS15/RPL37/RPS20	3
GO:0140104	molecular carrier activity	8/735	73/18367	0.00859995737423098	0.0603807533538112	RAN/PARK7/KPNA2/COX17/NDUFAB1/NUTF2/TIMM10/CSE1L	8
GO:0098631	cell adhesion mediator activity	7/735	59/18367	0.00894262404312721	0.0621326066329776	RPSA/PDLIM1/ANXA2/KRT18/S100A11/PPP1CA/CNN3	7
GO:0008200	ion channel inhibitor activity	5/735	33/18367	0.00948032028271331	0.0645242206996916	CALM2/PHPT1/CALM1/CAV1/ENSA	5
GO:0031369	translation initiation factor binding	5/735	33/18367	0.00948032028271331	0.0645242206996916	RPS24/EIF3F/EIF2S2/EIF3M/POLR2G	5
GO:0070034	telomerase RNA binding	4/735	22/18367	0.0104666998461915	0.0703439403778727	SNRPB/SNRPD3/NHP2/NOP10	4
GO:0043047	single-stranded telomeric DNA binding	3/735	12/18367	0.0107107069284676	0.0703439403778727	HNRNPA1/HNRNPA2B1/RPA2	3
GO:0016248	channel inhibitor activity	5/735	34/18367	0.0107572442556867	0.0703439403778727	CALM2/PHPT1/CALM1/CAV1/ENSA	5
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	5/735	34/18367	0.0107572442556867	0.0703439403778727	FEN1/RNASEH2A/POP7/RPP30/APEX1	5
GO:0017134	fibroblast growth factor binding	4/735	23/18367	0.0122769612204525	0.0795022634372994	RPS2/RPS19/S100A13/FIBP	4
GO:0046982	protein heterodimerization activity	22/735	328/18367	0.0129232462843683	0.0819525086089074	CENPW/RAN/TOP2A/YWHAH/TRMT112/LSM5/AURKA/YWHAE/PAFAH1B3/CAV1/GTF2A2/LSM6/PHB/SAE1/PHB2/TAF9/KRT10/NAE1/BAX/POLE4/POLE3/SMC3	22
GO:0098632	cell-cell adhesion mediator activity	6/735	49/18367	0.0130156841906992	0.0819525086089074	PDLIM1/ANXA2/KRT18/S100A11/PPP1CA/CNN3	6
GO:0042826	histone deacetylase binding	11/735	127/18367	0.0130346126632754	0.0819525086089074	GMNN/TOP2A/CDC20/KPNA2/HSP90AB1/HNRNPD/YWHAE/HSP90AA1/PHB/CCND1/PARP1	11
GO:0004859	phospholipase inhibitor activity	3/735	13/18367	0.013515406217361	0.0819525086089074	ANXA5/ANXA2/ANXA3	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/735	13/18367	0.013515406217361	0.0819525086089074	TXN/PRDX3/TXNDC17	3
GO:0019104	DNA N-glycosylase activity	3/735	13/18367	0.013515406217361	0.0819525086089074	PCNA/UNG/APEX1	3
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	3/735	13/18367	0.013515406217361	0.0819525086089074	CKS1B/CKS2/CCNB1	3
GO:0061631	ubiquitin conjugating enzyme activity	5/735	36/18367	0.0136531790279759	0.0820420757807199	UBE2C/UBE2T/UBE2S/UBE2L3/UBE2N	5
GO:0051537	2 iron, 2 sulfur cluster binding	4/735	24/18367	0.0142758030010123	0.0850175053721	NDUFV2/UQCRFS1/CISD1/ISCU	4
GO:0016860	intramolecular oxidoreductase activity	6/735	51/18367	0.0156795349410396	0.0925508832360477	TPI1/MIF/PTGES3/ECH1/ECI1/DDT	6
GO:0044548	S100 protein binding	3/735	14/18367	0.0166978551326108	0.0976970997671176	CACYBP/ANXA2/S100A11	3
GO:0097110	scaffold protein binding	7/735	67/18367	0.017360871589467	0.100693055218908	DYNLL1/PARK7/KRT8/KRT18/YWHAE/HSP90AA1/XRCC6	7
GO:0044325	transmembrane transporter binding	11/735	133/18367	0.0178759179824678	0.10278652839919	CALM2/S100A10/PHPT1/CALM1/YWHAH/VDAC1/HSP90AB1/YWHAE/CAV1/YWHAQ/BAG2	11
GO:0042393	histone binding	17/735	244/18367	0.0192327538473681	0.10964313518115	CKS1B/NASP/NPM1/DEK/ASF1B/CKS2/DNAJC9/VRK1/HAT1/ANP32B/NAP1L1/SET/RBBP7/PIH1D1/CBX5/YEATS4/ANP32E	17
GO:0030295	protein kinase activator activity	9/735	101/18367	0.0198690900236165	0.11169563698241	HMGB1/CKS1B/CALM2/RPLP1/CALM1/CKS2/CCNB1/TPX2/CD24	9
GO:0004549	tRNA-specific ribonuclease activity	3/735	15/18367	0.0202626267989079	0.11169563698241	POP7/TSEN34/RPP30	3
GO:0010851	cyclase regulator activity	3/735	15/18367	0.0202626267989079	0.11169563698241	CALM2/CALM1/GNAS	3
GO:0098847	sequence-specific single stranded DNA binding	3/735	15/18367	0.0202626267989079	0.11169563698241	HNRNPA1/HNRNPA2B1/RPA2	3
GO:0023026	MHC class II protein complex binding	4/735	27/18367	0.0214597084165008	0.117324799293492	PKM/HSP90AB1/YWHAE/HSP90AA1	4
GO:0004386	helicase activity	12/735	156/18367	0.0230188488774745	0.124089195250675	RAD51/RFC2/MCM7/RFC4/RFC3/HELLS/MCM5/XRCC6/MCM4/MCM3/DDX39A/RUVBL1	12
GO:0048487	beta-tubulin binding	5/735	41/18367	0.0230690557887311	0.124089195250675	CCT5/PDCD5/TBCA/UXT/SMC3	5
GO:0003688	DNA replication origin binding	3/735	16/18367	0.0242117631387005	0.129193968108106	CDC6/MCM5/HSPD1	3
GO:0015036	disulfide oxidoreductase activity	5/735	42/18367	0.0253520663204686	0.134204985998036	GSTO1/TXN/TXNDC17/TXN2/GLRX3	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	6/735	57/18367	0.0258772250751377	0.135906371063912	GSTO1/TXN/PRDX3/TXNDC17/TXN2/GLRX3	6
GO:0019209	kinase activator activity	9/735	107/18367	0.0277034314941727	0.144360850051665	HMGB1/CKS1B/CALM2/RPLP1/CALM1/CKS2/CCNB1/TPX2/CD24	9
GO:0008308	voltage-gated anion channel activity	3/735	17/18367	0.0285450315893605	0.146457969770027	VDAC1/VDAC3/VDAC2	3
GO:0043024	ribosomal small subunit binding	3/735	17/18367	0.0285450315893605	0.146457969770027	NPM1/NME1/UNG	3
GO:0022829	wide pore channel activity	4/735	30/18367	0.0305134751581366	0.155362503286085	VDAC1/VDAC3/VDAC2/TOMM40	4
GO:0000287	magnesium ion binding	15/735	221/18367	0.0326815302008934	0.161930866219431	DUT/RAN/TOP2A/ENO1/FEN1/NME1/PKM/PPA1/COMT/DCTPP1/IDH2/PGP/NUDT8/NUDT5/RHEB	15
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	5/735	45/18367	0.0330487166318518	0.161930866219431	FEN1/RNASEH2A/POP7/RPP30/APEX1	5
GO:0000295	adenine nucleotide transmembrane transporter activity	3/735	18/18367	0.0332601629266299	0.161930866219431	SLC25A5/SLC25A6/SLC29A1	3
GO:0004550	nucleoside diphosphate kinase activity	3/735	18/18367	0.0332601629266299	0.161930866219431	DTYMK/NME1/NME4	3
GO:0005346	purine ribonucleotide transmembrane transporter activity	3/735	18/18367	0.0332601629266299	0.161930866219431	SLC25A5/SLC25A6/SLC29A1	3
GO:0055102	lipase inhibitor activity	3/735	18/18367	0.0332601629266299	0.161930866219431	ANXA5/ANXA2/ANXA3	3
GO:0140142	nucleocytoplasmic carrier activity	4/735	31/18367	0.0339604127814236	0.164141995110214	RAN/KPNA2/NUTF2/CSE1L	4
GO:0031072	heat shock protein binding	10/735	129/18367	0.0343942995784865	0.165043149775903	RPS3/DNAJC9/PTGES3/HSP90AB1/DNAJC8/BAG2/AHSA1/TFAM/BAX/STIP1	10
GO:0140296	general transcription initiation factor binding	5/735	46/18367	0.0359035058674257	0.17105456009695	EDF1/GTF2A2/PSMC5/FBL/RUVBL1	5
GO:0035615	clathrin adaptor activity	3/735	19/18367	0.0383530713883857	0.181429068198959	AP2S1/AP1S1/AP1M2	3
GO:0016836	hydro-lyase activity	6/735	64/18367	0.0424242586308833	0.199274510611262	ENO1/PARK7/ECHS1/ECI1/FH/PCBD1	6
GO:0001091	RNA polymerase II general transcription initiation factor binding	3/735	20/18367	0.0438180582238912	0.202962811356496	EDF1/FBL/RUVBL1	3
GO:0140312	cargo adaptor activity	3/735	20/18367	0.0438180582238912	0.202962811356496	AP2S1/AP1S1/AP1M2	3
GO:0016763	pentosyltransferase activity	5/735	49/18367	0.0453562594747437	0.206261827068516	PNP/QPRT/PARP1/APRT/UMPS	5
GO:0043539	protein serine/threonine kinase activator activity	5/735	49/18367	0.0453562594747437	0.206261827068516	CKS1B/CALM2/CALM1/CKS2/CCNB1	5
GO:0051020	GTPase binding	18/735	291/18367	0.0454580038666744	0.206261827068516	RANBP1/BIRC5/ENO1/PFN1/YBX1/SOD1/LSM2/ANXA2/CLTA/HSP90AA1/DIAPH3/CAV1/NUTF2/STOML2/ECT2/NXT1/BNIP3/CSE1L	18
GO:0015216	purine nucleotide transmembrane transporter activity	3/735	21/18367	0.0496479997285531	0.220768105459633	SLC25A5/SLC25A6/SLC29A1	3
GO:0140416	transcription regulator inhibitor activity	3/735	21/18367	0.0496479997285531	0.220768105459633	MDFI/ID1/ID3	3
GO:1990381	ubiquitin-specific protease binding	3/735	21/18367	0.0496479997285531	0.220768105459633	PARK7/SUMO1/RAD23A	3
GO:0023023	MHC protein complex binding	4/735	36/18367	0.05445756626194	0.238968399320487	PKM/HSP90AB1/YWHAE/HSP90AA1	4
GO:0034061	DNA polymerase activity	4/735	36/18367	0.05445756626194	0.238968399320487	PTGES3/POLD3/POLE4/POLE3	4
GO:0004602	glutathione peroxidase activity	3/735	22/18367	0.0558345207626102	0.241828736030266	GSTP1/PRDX6/GPX4	3
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	3/735	22/18367	0.0558345207626102	0.241828736030266	BIRC5/PRDX5/PRDX3	3
GO:0004521	endoribonuclease activity	6/735	69/18367	0.0575643307601991	0.243953116367184	FEN1/RNASEH2A/POP7/TSEN34/RPP30/APEX1	6
GO:0004300	enoyl-CoA hydratase activity	2/735	10/18367	0.0581537413828819	0.243953116367184	ECHS1/ECI1	2
GO:0008641	ubiquitin-like modifier activating enzyme activity	2/735	10/18367	0.0581537413828819	0.243953116367184	SAE1/NAE1	2
GO:0033204	ribonuclease P RNA binding	2/735	10/18367	0.0581537413828819	0.243953116367184	POP7/RPP30	2
GO:0097027	ubiquitin-protein transferase activator activity	2/735	10/18367	0.0581537413828819	0.243953116367184	CDC20/UBE2L3	2
GO:0015035	protein-disulfide reductase activity	4/735	37/18367	0.0592063175265987	0.245283315467337	TXN/TXNDC17/TXN2/GLRX3	4
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4/735	37/18367	0.0592063175265987	0.245283315467337	GAPDH/AKR1B1/ADH5/ALDH7A1	4
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	3/735	23/18367	0.0623681546939339	0.255930521234301	ADI1/ETHE1/PIR	3
GO:0048306	calcium-dependent protein binding	7/735	88/18367	0.0625437405715007	0.255930521234301	CALM2/S100A10/CALM1/ANXA2/S100A11/ANXA3/S100A13	7
GO:0004520	endodeoxyribonuclease activity	4/735	38/18367	0.0641679861504375	0.260975894892328	RPS3/FEN1/RAD51C/APEX1	4
GO:0051117	ATPase binding	7/735	89/18367	0.0656601603722934	0.265426224050422	SNU13/CAV1/PIH1D1/FBL/TAF9/RUVBL1/NSFL1C	7
GO:0030276	clathrin binding	6/735	72/18367	0.0680182832533517	0.267340143953659	AP2S1/CLTA/CLTB/NSG1/AP1S1/AP1M2	6
GO:0000774	adenyl-nucleotide exchange factor activity	2/735	11/18367	0.0692376003432452	0.267340143953659	PFN1/BAG2	2
GO:0005049	nuclear export signal receptor activity	2/735	11/18367	0.0692376003432452	0.267340143953659	RAN/CSE1L	2
GO:0005347	ATP transmembrane transporter activity	2/735	11/18367	0.0692376003432452	0.267340143953659	SLC25A5/SLC25A6	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/735	11/18367	0.0692376003432452	0.267340143953659	TXN/TXNDC17	2
GO:1901612	cardiolipin binding	2/735	11/18367	0.0692376003432452	0.267340143953659	STOML2/NME4	2
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3/735	24/18367	0.0692384906500656	0.267340143953659	ADI1/ETHE1/PIR	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4/735	39/18367	0.0693400973073209	0.267340143953659	DTYMK/NME1/NME4/AK2	4
GO:0008047	enzyme activator activity	8/735	110/18367	0.0739938043211232	0.283642916564306	CALM2/CALM1/PARK7/GNAS/PDCD5/SAE1/CYB5B/RFC1	8
GO:0003725	double-stranded RNA binding	6/735	74/18367	0.0755599986801787	0.285940604039655	TUBA1B/HMGB1/TUBB4B/HSP90AB1/HSPD1/ILF2	6
GO:0043130	ubiquitin binding	7/735	92/18367	0.0755627194723533	0.285940604039655	CKS1B/TOP2A/CKS2/UBE2N/BUB3/RAD23A/NSFL1C	7
GO:0003887	DNA-directed DNA polymerase activity	3/735	25/18367	0.0764343089125745	0.285940604039655	POLD3/POLE4/POLE3	3
GO:0008327	methyl-CpG binding	3/735	25/18367	0.0764343089125745	0.285940604039655	ERH/PRMT1/DNMT1	3
GO:0032182	ubiquitin-like protein binding	8/735	111/18367	0.0771001421396379	0.285940604039655	CKS1B/TOP2A/CKS2/UBE2N/SERBP1/BUB3/RAD23A/NSFL1C	8
GO:0004536	deoxyribonuclease activity	5/735	57/18367	0.0771653804005066	0.285940604039655	RPS3/FEN1/NME1/RAD51C/APEX1	5
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/735	12/18367	0.0809429790262007	0.29183225411068	RPS3/APEX1	2
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	2/735	12/18367	0.0809429790262007	0.29183225411068	AKR7A2/AKR1B1	2
GO:0004526	ribonuclease P activity	2/735	12/18367	0.0809429790262007	0.29183225411068	POP7/RPP30	2
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/735	12/18367	0.0809429790262007	0.29183225411068	CDK1/CDK4	2
GO:0046790	virion binding	2/735	12/18367	0.0809429790262007	0.29183225411068	PPIA/ANXA2	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	5/735	58/18367	0.0818109796226037	0.293375932302563	GSTO1/GSTP1/FDPS/SMS/SRM	5
GO:0033218	amide binding	22/735	400/18367	0.0828671244104521	0.295574181720703	TYMS/PPIA/DBI/DHFR/VDAC1/KPNA2/CLTA/HSP90AB1/FKBP3/SRP14/VDAC2/ACBD6/PPIF/PPIL1/PPIH/PFDN2/PHB2/PPIC/CLTB/PFDN4/VBP1/PFDN1	22
GO:0097602	cullin family protein binding	3/735	26/18367	0.0839437052376387	0.297821549965452	ANAPC11/RBX1/SKP1	3
GO:0051539	4 iron, 4 sulfur cluster binding	4/735	42/18367	0.0860879707357874	0.303813103072858	NDUFS8/NFU1/NUBP2/NDUFV1	4
GO:0015215	nucleotide transmembrane transporter activity	3/735	27/18367	0.0917542048402809	0.313970164941335	SLC25A5/SLC25A6/SLC29A1	3
GO:0005246	calcium channel regulator activity	4/735	43/18367	0.092068801195972	0.313970164941335	CALM2/PHPT1/CALM1/YWHAE	4
GO:0030544	Hsp70 protein binding	4/735	43/18367	0.092068801195972	0.313970164941335	RPS3/DNAJC8/BAX/STIP1	4
GO:0005542	folic acid binding	2/735	13/18367	0.093202537718717	0.313970164941335	TYMS/DHFR	2
GO:0008179	adenylate cyclase binding	2/735	13/18367	0.093202537718717	0.313970164941335	CALM2/CALM1	2
GO:0031432	titin binding	2/735	13/18367	0.093202537718717	0.313970164941335	CALM2/CALM1	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/735	13/18367	0.093202537718717	0.313970164941335	ANAPC11/RBX1	2
GO:0060590	ATPase regulator activity	2/735	13/18367	0.093202537718717	0.313970164941335	PFN1/BAG2	2
GO:0072542	protein phosphatase activator activity	2/735	13/18367	0.093202537718717	0.313970164941335	CALM2/CALM1	2
GO:0005507	copper ion binding	5/735	61/18367	0.0966119404828301	0.323819921115818	SOD1/PARK7/COX17/S100A13/COA6	5
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	4/735	44/18367	0.0982417059415234	0.326006059019881	GAPDH/AKR1B1/ADH5/ALDH7A1	4
GO:0051879	Hsp90 protein binding	4/735	44/18367	0.0982417059415234	0.326006059019881	RPS3/PTGES3/AHSA1/STIP1	4
GO:0048156	tau protein binding	4/735	45/18367	0.104601997581491	0.345393724687399	HSP90AB1/HSP90AA1/BAG2/PIN1	4
GO:0099106	ion channel regulator activity	9/735	139/18367	0.105839547908304	0.34642580002879	CALM2/PHPT1/CALM1/YWHAH/YWHAE/CAV1/VAMP8/SUMO1/ENSA	9
GO:0017110	nucleoside-diphosphatase activity	2/735	14/18367	0.105953318149735	0.34642580002879	NUDT15/NUDT5	2
GO:0046625	sphingolipid binding	3/735	29/18367	0.108226379090368	0.350422305112989	VDAC1/VDAC2/PHB2	3
GO:0051059	NF-kappaB binding	3/735	29/18367	0.108226379090368	0.350422305112989	NPM1/CDKN2A/APEX1	3
GO:0022853	active ion transmembrane transporter activity	15/735	267/18367	0.117887049958931	0.374830407815077	SLC25A5/UQCRH/SLC25A6/SLC25A3/COX5A/UQCR10/COX8A/CYB5A/COX4I1/COX5B/COX7B/COX6B1/UQCRFS1/CYC1/SLC25A1	15
GO:0001846	opsonin binding	2/735	15/18367	0.119136501434477	0.374830407815077	C1QBP/PHB	2
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/735	15/18367	0.119136501434477	0.374830407815077	ADH5/ALDH7A1	2
GO:0032794	GTPase activating protein binding	2/735	15/18367	0.119136501434477	0.374830407815077	TUBB/PIN1	2
GO:0050998	nitric-oxide synthase binding	2/735	15/18367	0.119136501434477	0.374830407815077	CALM1/CAV1	2
GO:1901611	phosphatidylglycerol binding	2/735	15/18367	0.119136501434477	0.374830407815077	STOML2/NME4	2
GO:0016247	channel regulator activity	9/735	145/18367	0.127856786472009	0.400377824304366	CALM2/PHPT1/CALM1/YWHAH/YWHAE/CAV1/VAMP8/SUMO1/ENSA	9
GO:0019212	phosphatase inhibitor activity	4/735	49/18367	0.131814085602692	0.400493293885493	PPP1R14B/SET/ENSA/ANP32E	4
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/735	16/18367	0.132697178333874	0.400493293885493	TYMS/DHFR	2
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/735	16/18367	0.132697178333874	0.400493293885493	ADH5/ALDH7A1	2
GO:0005092	GDP-dissociation inhibitor activity	2/735	16/18367	0.132697178333874	0.400493293885493	RANBP1/ITGB1BP1	2
GO:0005159	insulin-like growth factor receptor binding	2/735	16/18367	0.132697178333874	0.400493293885493	YWHAH/GNAS	2
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/735	16/18367	0.132697178333874	0.400493293885493	FEN1/APEX1	2
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	2/735	16/18367	0.132697178333874	0.400493293885493	RAD51C/TSEN34	2
GO:0070402	NADPH binding	2/735	16/18367	0.132697178333874	0.400493293885493	DHFR/GRHPR	2
GO:0015605	organophosphate ester transmembrane transporter activity	3/735	32/18367	0.134859110190426	0.40305042093467	SLC25A5/SLC25A6/SLC29A1	3
GO:0030332	cyclin binding	3/735	32/18367	0.134859110190426	0.40305042093467	CDK1/XRCC6/CDK4	3
GO:0003727	single-stranded RNA binding	6/735	87/18367	0.135357262802648	0.40305042093467	HMGB1/HNRNPA1/SNRPC/HNRNPF/SSB/POLR2G	6
GO:0015932	nucleobase-containing compound transmembrane transporter activity	4/735	50/18367	0.139032140488655	0.410329370380234	SLC25A5/SLC25A6/HNRNPA3/SLC29A1	4
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4/735	50/18367	0.139032140488655	0.410329370380234	PCNA/UNG/DNPH1/APEX1	4
GO:0008276	protein methyltransferase activity	6/735	88/18367	0.140685081502488	0.413378631551363	TRMT112/EZH2/LCMT1/FBL/PRMT1/NTMT1	6
GO:0001530	lipopolysaccharide binding	3/735	33/18367	0.144194373022443	0.421831784236708	HMGB1/HSPD1/PSMB4	3
GO:0004519	endonuclease activity	8/735	129/18367	0.145915171405973	0.423253746893966	RPS3/FEN1/RNASEH2A/RAD51C/POP7/TSEN34/RPP30/APEX1	8
GO:0030275	LRR domain binding	2/735	17/18367	0.146584131233143	0.423253746893966	POLR2J/PMF1	2
GO:0070064	proline-rich region binding	2/735	17/18367	0.146584131233143	0.423253746893966	PFN1/CCND1	2
GO:0140677	molecular function activator activity	9/735	150/18367	0.147915036432432	0.425255729743242	CALM2/CALM1/PARK7/GNAS/PDCD5/SAE1/AHSA1/CYB5B/RFC1	9
GO:0016831	carboxy-lyase activity	3/735	34/18367	0.153735146519563	0.435033674134791	PAICS/DDT/UMPS	3
GO:0035198	miRNA binding	3/735	34/18367	0.153735146519563	0.435033674134791	HNRNPA1/YBX1/HNRNPA2B1	3
GO:0045505	dynein intermediate chain binding	3/735	34/18367	0.153735146519563	0.435033674134791	DYNLL1/DYNLT1/DYNLRB1	3
GO:0016830	carbon-carbon lyase activity	4/735	52/18367	0.153924958164634	0.435033674134791	ALDOA/PAICS/DDT/UMPS	4
GO:0031491	nucleosome binding	5/735	71/18367	0.154627776356686	0.435176062573459	HMGN2/VRK1/HMGN1/ACTL6A/SUPT16H	5
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/735	18/18367	0.160749627271457	0.448619252678082	AKR7A2/AKR1B1	2
GO:1904047	S-adenosyl-L-methionine binding	2/735	18/18367	0.160749627271457	0.448619252678082	METTL5/PRMT1	2
GO:0140297	DNA-binding transcription factor binding	20/735	394/18367	0.164997219829432	0.458554773442631	PCNA/HMGB1/GMNN/PTMA/NPM1/RPS3/CHCHD2/HMGA1/YWHAH/PARK7/CDKN2A/GTF2A2/PSMC5/APEX1/PARP1/PHB2/MKKS/TAF9/CBX5/BUD31	20
GO:0106306	protein serine phosphatase activity	5/735	73/18367	0.167661695614316	0.462108888325407	CDKN3/PPP1CA/DUSP9/PPM1G/PPP4C	5
GO:0106307	protein threonine phosphatase activity	5/735	73/18367	0.167661695614316	0.462108888325407	CDKN3/PPP1CA/DUSP9/PPM1G/PPP4C	5
GO:0015459	potassium channel regulator activity	4/735	54/18367	0.169385269894223	0.464938168804306	YWHAE/CAV1/SUMO1/ENSA	4
GO:0010314	phosphatidylinositol-5-phosphate binding	2/735	19/18367	0.17514922208123	0.478789062000738	PHLDA3/SNX3	2
GO:0005080	protein kinase C binding	4/735	55/18367	0.177312322452258	0.482723751329209	TOP2A/HINT1/C1QBP/GLRX3	4
GO:0042056	chemoattractant activity	3/735	37/18367	0.183451380197319	0.496304429824168	HMGB2/HMGB1/MIF	3
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/735	56/18367	0.185362007301889	0.496304429824168	PTTG1/BIRC5/PRDX5/PRDX3	4
GO:0042054	histone methyltransferase activity	4/735	56/18367	0.185362007301889	0.496304429824168	EZH2/FBL/PRMT1/NTMT1	4
GO:0019211	phosphatase activator activity	2/735	20/18367	0.189741573620934	0.496304429824168	CALM2/CALM1	2
GO:0031681	G-protein beta-subunit binding	2/735	20/18367	0.189741573620934	0.496304429824168	CCT5/GNG5	2
GO:0031690	adrenergic receptor binding	2/735	20/18367	0.189741573620934	0.496304429824168	GNAS/C1QBP	2
GO:0042288	MHC class I protein binding	2/735	20/18367	0.189741573620934	0.496304429824168	TUBB/TUBB4B	2
GO:0050145	nucleoside monophosphate kinase activity	2/735	20/18367	0.189741573620934	0.496304429824168	DTYMK/AK2	2
GO:0061608	nuclear import signal receptor activity	2/735	20/18367	0.189741573620934	0.496304429824168	KPNA2/NUTF2	2
GO:0097001	ceramide binding	2/735	20/18367	0.189741573620934	0.496304429824168	VDAC1/VDAC2	2
GO:0016741	transferase activity, transferring one-carbon groups	12/735	225/18367	0.192142217679362	0.500620543719276	TYMS/GCSH/TRMT112/COMT/EZH2/LCMT1/ATIC/METTL5/FBL/PRMT1/NTMT1/DNMT1	12
GO:0001221	transcription coregulator binding	5/735	78/18367	0.201992231542807	0.52423664762277	RPL23/CBX3/UBE2I/EZH2/TFAM	5
GO:0005504	fatty acid binding	3/735	39/18367	0.204036968932982	0.524591050621565	GSTP1/NDUFAB1/ADH5	3
GO:0001848	complement binding	2/735	21/18367	0.204488265609606	0.524591050621565	C1QBP/PHB	2
GO:0051428	peptide hormone receptor binding	2/735	21/18367	0.204488265609606	0.524591050621565	GNAS/PSMC5	2
GO:0031492	nucleosomal DNA binding	3/735	40/18367	0.214522149574292	0.545928649040677	HMGN2/HMGN1/ACTL6A	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/735	40/18367	0.214522149574292	0.545928649040677	BIRC5/PRDX5/PRDX3	3
GO:0003714	transcription corepressor activity	10/735	187/18367	0.217180441356792	0.545928649040677	GMNN/PA2G4/HSBP1/SAP18/C1QBP/EZH2/APEX1/PHB/CCND1/UXT	10
GO:0000062	fatty-acyl-CoA binding	2/735	22/18367	0.219353640094305	0.545928649040677	DBI/ACBD6	2
GO:0005540	hyaluronic acid binding	2/735	22/18367	0.219353640094305	0.545928649040677	HMMR/C1QBP	2
GO:0008106	alcohol dehydrogenase (NADP+) activity	2/735	22/18367	0.219353640094305	0.545928649040677	AKR7A2/AKR1B1	2
GO:0008649	rRNA methyltransferase activity	2/735	22/18367	0.219353640094305	0.545928649040677	METTL5/FBL	2
GO:0140102	catalytic activity, acting on a rRNA	2/735	22/18367	0.219353640094305	0.545928649040677	METTL5/FBL	2
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/735	41/18367	0.225118350944364	0.556125703999595	SAE1/NAE1/SUCLG1	3
GO:0030331	estrogen receptor binding	3/735	41/18367	0.225118350944364	0.556125703999595	PCNA/PARP1/PHB2	3
GO:0031490	chromatin DNA binding	6/735	103/18367	0.230826017767827	0.567824072379256	HMGN2/HMGN1/EZH2/ACTL6A/APEX1/POLE3	6
GO:0004529	exodeoxyribonuclease activity	2/735	23/18367	0.234304638703864	0.567824072379256	FEN1/APEX1	2
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/735	23/18367	0.234304638703864	0.567824072379256	FEN1/APEX1	2
GO:0017025	TBP-class protein binding	2/735	23/18367	0.234304638703864	0.567824072379256	GTF2A2/RUVBL1	2
GO:1901567	fatty acid derivative binding	2/735	23/18367	0.234304638703864	0.567824072379256	DBI/ACBD6	2
GO:0001046	core promoter sequence-specific DNA binding	3/735	42/18367	0.235812995575793	0.567824072379256	NPM1/EZH2/PIH1D1	3
GO:0008307	structural constituent of muscle	3/735	42/18367	0.235812995575793	0.567824072379256	CSRP2/KRT19/MYL6	3
GO:0008168	methyltransferase activity	11/735	214/18367	0.239412643435108	0.574418104932435	TYMS/GCSH/TRMT112/COMT/EZH2/LCMT1/METTL5/FBL/PRMT1/NTMT1/DNMT1	11
GO:0015631	tubulin binding	18/735	375/18367	0.246391374483742	0.587597897501489	STMN1/NUSAP1/GAPDH/BIRC5/PRC1/RPS3/ALDOA/TPX2/CACYBP/NME1/SKA2/CCT5/PDCD5/CNN3/TBCA/UXT/VBP1/SMC3	18
GO:0008171	O-methyltransferase activity	2/735	24/18367	0.249310652163301	0.587597897501489	COMT/LCMT1	2
GO:0019789	SUMO transferase activity	2/735	24/18367	0.249310652163301	0.587597897501489	SUMO2/UBE2I	2
GO:0043274	phospholipase binding	2/735	24/18367	0.249310652163301	0.587597897501489	LMNB1/SRSF3	2
GO:0120014	phospholipid transfer activity	2/735	24/18367	0.249310652163301	0.587597897501489	PRELID1/TRIAP1	2
GO:0005525	GTP binding	18/735	377/18367	0.25336099566705	0.595041493344798	TUBA1B/TUBB/TUBA1C/TUBB4B/RAN/EEF1A1/NME1/GNAS/HSP90AB1/ARL2/TUBB6/TUBG1/OLA1/RHOC/RAB25/RHEB/HRAS/GPN3	18
GO:0004712	protein serine/threonine/tyrosine kinase activity	3/735	44/18367	0.257448842169847	0.60047127867086	PBK/AURKB/AURKA	3
GO:0019208	phosphatase regulator activity	6/735	107/18367	0.257473441828884	0.60047127867086	CALM2/CALM1/PPP1R14B/SET/ENSA/ANP32E	6
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/735	25/18367	0.264343377663364	0.612211919796749	HNRNPD/EXOSC8	2
GO:0120227	acyl-CoA binding	2/735	25/18367	0.264343377663364	0.612211919796749	DBI/ACBD6	2
GO:0003924	GTPase activity	16/735	337/18367	0.276528293974607	0.635987194631832	TUBA1B/TUBB/TUBA1C/TUBB4B/RAN/EEF1A1/GNAS/ARL2/TUBB6/TUBG1/GNG5/RHOC/RAB25/RHEB/HRAS/GPN3	16
GO:0004864	protein phosphatase inhibitor activity	3/735	46/18367	0.279335434124862	0.635987194631832	PPP1R14B/SET/ENSA	3
GO:0061980	regulatory RNA binding	3/735	46/18367	0.279335434124862	0.635987194631832	HNRNPA1/YBX1/HNRNPA2B1	3
GO:0004364	glutathione transferase activity	2/735	26/18367	0.279376683698841	0.635987194631832	GSTO1/GSTP1	2
GO:0030371	translation repressor activity	2/735	26/18367	0.279376683698841	0.635987194631832	TYMS/DHFR	2
GO:0019888	protein phosphatase regulator activity	5/735	89/18367	0.284248407021822	0.643637841260761	CALM2/CALM1/PPP1R14B/SET/ENSA	5
GO:0003730	mRNA 3'-UTR binding	10/735	201/18367	0.28561123373721	0.643637841260761	RPS7/RPL41/RPL5/CARHSP1/CCT5/HNRNPA2B1/HNRNPD/EXOSC8/SERBP1/HNRNPR	10
GO:0140098	catalytic activity, acting on RNA	18/735	386/18367	0.285632385327114	0.643637841260761	POLR2L/FEN1/RNASEH2A/POLR2H/POP7/POLR3K/TSEN34/POLR2I/POLR2J/RPP30/APEX1/DDX39A/POLR2E/METTL5/POLR2G/FBL/POLR2K/POLR2F	18
GO:0022884	macromolecule transmembrane transporter activity	2/735	27/18367	0.294386482007526	0.661130584171783	HNRNPA3/TOMM40	2
GO:0016407	acetyltransferase activity	5/735	91/18367	0.299887846307278	0.671225481499847	ACAT2/HAT1/PAFAH1B3/TAF9/NAA10	5
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/735	28/18367	0.309350606259197	0.690089813962825	PHLDA3/SNX3	2
GO:0034212	peptide N-acetyltransferase activity	3/735	49/18367	0.312442950904692	0.690377773104642	HAT1/TAF9/NAA10	3
GO:0004540	ribonuclease activity	6/735	116/18367	0.319975302663751	0.690377773104642	FEN1/RNASEH2A/POP7/TSEN34/RPP30/APEX1	6
GO:0015485	cholesterol binding	3/735	50/18367	0.32351172603763	0.690377773104642	VDAC1/CAV1/VDAC2	3
GO:0004033	aldo-keto reductase (NADP) activity	2/735	29/18367	0.324248697160592	0.690377773104642	AKR7A2/AKR1B1	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2/735	29/18367	0.324248697160592	0.690377773104642	CDK1/CDK4	2
GO:0015301	anion:anion antiporter activity	2/735	29/18367	0.324248697160592	0.690377773104642	SLC25A5/SLC25A6	2
GO:0097472	cyclin-dependent protein kinase activity	2/735	29/18367	0.324248697160592	0.690377773104642	CDK1/CDK4	2
GO:0000049	tRNA binding	4/735	72/18367	0.325534045717674	0.690377773104642	EEF1A1/RPL35A/SSB/HSD17B10	4
GO:0019001	guanyl nucleotide binding	18/735	398/18367	0.330616390165414	0.690377773104642	TUBA1B/TUBB/TUBA1C/TUBB4B/RAN/EEF1A1/NME1/GNAS/HSP90AB1/ARL2/TUBB6/TUBG1/OLA1/RHOC/RAB25/RHEB/HRAS/GPN3	18
GO:0032561	guanyl ribonucleotide binding	18/735	398/18367	0.330616390165414	0.690377773104642	TUBA1B/TUBB/TUBA1C/TUBB4B/RAN/EEF1A1/NME1/GNAS/HSP90AB1/ARL2/TUBB6/TUBG1/OLA1/RHOC/RAB25/RHEB/HRAS/GPN3	18
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/735	10/18367	0.335355919768971	0.690377773104642	ACP1	1
GO:0005522	profilin binding	1/735	10/18367	0.335355919768971	0.690377773104642	ACTG1	1
GO:0005528	FK506 binding	1/735	10/18367	0.335355919768971	0.690377773104642	FKBP3	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/735	10/18367	0.335355919768971	0.690377773104642	DUSP9	1
GO:0016783	sulfurtransferase activity	1/735	10/18367	0.335355919768971	0.690377773104642	TSTD1	1
GO:0016803	ether hydrolase activity	1/735	10/18367	0.335355919768971	0.690377773104642	AKR7A2	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/735	10/18367	0.335355919768971	0.690377773104642	PGAM1	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/735	10/18367	0.335355919768971	0.690377773104642	GMPS	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/735	10/18367	0.335355919768971	0.690377773104642	ADH5	1
GO:0019869	chloride channel inhibitor activity	1/735	10/18367	0.335355919768971	0.690377773104642	VAMP8	1
GO:0030957	Tat protein binding	1/735	10/18367	0.335355919768971	0.690377773104642	NPM1	1
GO:0032356	oxidized DNA binding	1/735	10/18367	0.335355919768971	0.690377773104642	RPS3	1
GO:0034511	U3 snoRNA binding	1/735	10/18367	0.335355919768971	0.690377773104642	SNU13	1
GO:0043139	5'-3' DNA helicase activity	1/735	10/18367	0.335355919768971	0.690377773104642	RUVBL1	1
GO:0048256	flap endonuclease activity	1/735	10/18367	0.335355919768971	0.690377773104642	FEN1	1
GO:0031267	small GTPase binding	12/735	259/18367	0.343216785559855	0.693771524113793	RANBP1/BIRC5/PFN1/SOD1/LSM2/ANXA2/DIAPH3/CAV1/NUTF2/ECT2/NXT1/CSE1L	12
GO:0019003	GDP binding	4/735	75/18367	0.353017356582039	0.693771524113793	RAN/ARL2/RHEB/HRAS	4
GO:0031210	phosphatidylcholine binding	2/735	31/18367	0.353773729935948	0.693771524113793	VDAC1/VDAC2	2
GO:0140318	protein transporter activity	2/735	31/18367	0.353773729935948	0.693771524113793	TIMM8B/TOMM40	2
GO:0016922	nuclear receptor binding	7/735	144/18367	0.354626036140551	0.693771524113793	PCNA/HMGA1/YWHAH/PARK7/PARP1/PHB2/BUD31	7
GO:0004722	protein serine/threonine phosphatase activity	5/735	98/18367	0.355464670950654	0.693771524113793	CDKN3/PPP1CA/DUSP9/PPM1G/PPP4C	5
GO:0050661	NADP binding	3/735	53/18367	0.356684748447665	0.693771524113793	GAPDH/DHFR/GRHPR	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/735	53/18367	0.356684748447665	0.693771524113793	SLC25A5/SLC25A6/SLC29A1	3
GO:0004596	peptide alpha-N-acetyltransferase activity	1/735	11/18367	0.361967751711544	0.693771524113793	NAA10	1
GO:0005536	glucose binding	1/735	11/18367	0.361967751711544	0.693771524113793	UGP2	1
GO:0008199	ferric iron binding	1/735	11/18367	0.361967751711544	0.693771524113793	RRM2	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/735	11/18367	0.361967751711544	0.693771524113793	PKIB	1
GO:0010485	H4 histone acetyltransferase activity	1/735	11/18367	0.361967751711544	0.693771524113793	HAT1	1
GO:0016273	arginine N-methyltransferase activity	1/735	11/18367	0.361967751711544	0.693771524113793	PRMT1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/735	11/18367	0.361967751711544	0.693771524113793	PRMT1	1
GO:0016801	hydrolase activity, acting on ether bonds	1/735	11/18367	0.361967751711544	0.693771524113793	AKR7A2	1
GO:0016832	aldehyde-lyase activity	1/735	11/18367	0.361967751711544	0.693771524113793	ALDOA	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/735	11/18367	0.361967751711544	0.693771524113793	HSD17B10	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/735	11/18367	0.361967751711544	0.693771524113793	PIN1	1
GO:0032404	mismatch repair complex binding	1/735	11/18367	0.361967751711544	0.693771524113793	PCNA	1
GO:0043522	leucine zipper domain binding	1/735	11/18367	0.361967751711544	0.693771524113793	PMF1	1
GO:0051400	BH domain binding	1/735	11/18367	0.361967751711544	0.693771524113793	BAX	1
GO:0070513	death domain binding	1/735	11/18367	0.361967751711544	0.693771524113793	BAX	1
GO:0099186	structural constituent of postsynapse	1/735	11/18367	0.361967751711544	0.693771524113793	ACTG1	1
GO:0005544	calcium-dependent phospholipid binding	3/735	54/18367	0.367702364833161	0.702004232262747	ANXA5/ANXA2/ANXA3	3
GO:0001223	transcription coactivator binding	2/735	32/18367	0.368368037918983	0.702004232262747	RPL23/TFAM	2
GO:0051427	hormone receptor binding	2/735	33/18367	0.382830855009082	0.71396357301369	GNAS/PSMC5	2
GO:0140323	solute:anion antiporter activity	2/735	33/18367	0.382830855009082	0.71396357301369	SLC25A5/SLC25A6	2
GO:0003964	RNA-directed DNA polymerase activity	1/735	12/18367	0.387515458319303	0.71396357301369	PTGES3	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/735	12/18367	0.387515458319303	0.71396357301369	CDKN2A	1
GO:0005527	macrolide binding	1/735	12/18367	0.387515458319303	0.71396357301369	FKBP3	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/735	12/18367	0.387515458319303	0.71396357301369	APEX1	1
GO:0008429	phosphatidylethanolamine binding	1/735	12/18367	0.387515458319303	0.71396357301369	PEBP1	1
GO:0030955	potassium ion binding	1/735	12/18367	0.387515458319303	0.71396357301369	PKM	1
GO:0033130	acetylcholine receptor binding	1/735	12/18367	0.387515458319303	0.71396357301369	LY6E	1
GO:0035256	G protein-coupled glutamate receptor binding	1/735	12/18367	0.387515458319303	0.71396357301369	CALM1	1
GO:0042975	peroxisome proliferator activated receptor binding	1/735	12/18367	0.387515458319303	0.71396357301369	HMGA1	1
GO:0061578	Lys63-specific deubiquitinase activity	1/735	12/18367	0.387515458319303	0.71396357301369	PSMD14	1
GO:0030374	nuclear receptor coactivator activity	3/735	56/18367	0.389629296217366	0.71396357301369	HMGA1/ENY2/BUD31	3
GO:0045309	protein phosphorylated amino acid binding	3/735	56/18367	0.389629296217366	0.71396357301369	PFN1/YWHAE/PIN1	3
GO:0004721	phosphoprotein phosphatase activity	8/735	174/18367	0.395586586442098	0.722893844265423	CDKN3/PHPT1/PPP1CA/PGP/DUSP9/PPM1G/ACP1/PPP4C	8
GO:0030291	protein serine/threonine kinase inhibitor activity	2/735	34/18367	0.397149336789677	0.723766687537472	PKIB/CDKN2A	2
GO:0042277	peptide binding	14/735	321/18367	0.409424158419156	0.730935382630383	PPIA/KPNA2/CLTA/HSP90AB1/SRP14/PPIF/PPIL1/PPIH/PFDN2/PPIC/CLTB/PFDN4/VBP1/PFDN1	14
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/735	13/18367	0.412041535036018	0.730935382630383	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/735	13/18367	0.412041535036018	0.730935382630383	HSPD1	1
GO:0016840	carbon-nitrogen lyase activity	1/735	13/18367	0.412041535036018	0.730935382630383	GGCT	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/735	13/18367	0.412041535036018	0.730935382630383	DUSP9	1
GO:0032036	myosin heavy chain binding	1/735	13/18367	0.412041535036018	0.730935382630383	MYL12B	1
GO:0042301	phosphate ion binding	1/735	13/18367	0.412041535036018	0.730935382630383	PNP	1
GO:0052650	NADP-retinol dehydrogenase activity	1/735	13/18367	0.412041535036018	0.730935382630383	AKR1B1	1
GO:0061133	endopeptidase activator activity	1/735	13/18367	0.412041535036018	0.730935382630383	PSMD14	1
GO:0140299	small molecule sensor activity	1/735	13/18367	0.412041535036018	0.730935382630383	PARK7	1
GO:0036002	pre-mRNA binding	3/735	59/18367	0.422140729533148	0.74686436763557	HNRNPA1/SLBP/SNRPC	3
GO:0042805	actinin binding	2/735	36/18367	0.425308016701799	0.750477373386508	CSRP2/PDLIM1	2
GO:0032934	sterol binding	3/735	60/18367	0.432850449026338	0.754639958233859	VDAC1/CAV1/VDAC2	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	7/735	156/18367	0.433540356168927	0.754639958233859	COMT/EZH2/LCMT1/METTL5/FBL/PRMT1/DNMT1	7
GO:0001540	amyloid-beta binding	4/735	84/18367	0.434973689645035	0.754639958233859	PFDN2/PFDN4/VBP1/PFDN1	4
GO:0030983	mismatched DNA binding	1/735	14/18367	0.435586782488809	0.754639958233859	PCNA	1
GO:0032977	membrane insertase activity	1/735	14/18367	0.435586782488809	0.754639958233859	TIMM10	1
GO:0035259	glucocorticoid receptor binding	1/735	14/18367	0.435586782488809	0.754639958233859	YWHAH	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/735	14/18367	0.435586782488809	0.754639958233859	HSD17B10	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/735	38/18367	0.452764658420349	0.773703745450947	GTF2A2/TAF9	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/735	38/18367	0.452764658420349	0.773703745450947	RPS3/PARK7	2
GO:0016846	carbon-sulfur lyase activity	1/735	15/18367	0.45819037399269	0.773703745450947	GLO1	1
GO:0019215	intermediate filament binding	1/735	15/18367	0.45819037399269	0.773703745450947	NME1	1
GO:0030280	structural constituent of skin epidermis	1/735	15/18367	0.45819037399269	0.773703745450947	KRT10	1
GO:0030548	acetylcholine receptor regulator activity	1/735	15/18367	0.45819037399269	0.773703745450947	LY6E	1
GO:0043138	3'-5' DNA helicase activity	1/735	15/18367	0.45819037399269	0.773703745450947	MCM5	1
GO:0051371	muscle alpha-actinin binding	1/735	15/18367	0.45819037399269	0.773703745450947	PDLIM1	1
GO:0070742	C2H2 zinc finger domain binding	1/735	15/18367	0.45819037399269	0.773703745450947	TAF9	1
GO:0099602	neurotransmitter receptor regulator activity	1/735	15/18367	0.45819037399269	0.773703745450947	LY6E	1
GO:0004518	nuclease activity	9/735	210/18367	0.465038843962337	0.781310725446961	RPS3/FEN1/RNASEH2A/NME1/RAD51C/POP7/TSEN34/RPP30/APEX1	9
GO:0004402	histone acetyltransferase activity	2/735	39/18367	0.466209398392639	0.781310725446961	HAT1/TAF9	2
GO:0050997	quaternary ammonium group binding	2/735	39/18367	0.466209398392639	0.781310725446961	VDAC1/VDAC2	2
GO:0051219	phosphoprotein binding	4/735	88/18367	0.4705468333712	0.786603353029048	PFN1/YWHAE/PIH1D1/PIN1	4
GO:0042287	MHC protein binding	2/735	40/18367	0.479456095698868	0.788390583464909	TUBB/TUBB4B	2
GO:0005521	lamin binding	1/735	16/18367	0.479889920369945	0.788390583464909	TMPO	1
GO:0010181	FMN binding	1/735	16/18367	0.479889920369945	0.788390583464909	NDUFV1	1
GO:0016208	AMP binding	1/735	16/18367	0.479889920369945	0.788390583464909	APRT	1
GO:0032183	SUMO binding	1/735	16/18367	0.479889920369945	0.788390583464909	SERBP1	1
GO:0070403	NAD+ binding	1/735	16/18367	0.479889920369945	0.788390583464909	HADH	1
GO:1990404	protein ADP-ribosylase activity	1/735	16/18367	0.479889920369945	0.788390583464909	PARP1	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/735	41/18367	0.49249905696833	0.802839572046619	HAT1/TAF9	2
GO:0002039	p53 binding	3/735	66/18367	0.495380484906291	0.802839572046619	HSPD1/TRIAP1/TAF9	3
GO:0004659	prenyltransferase activity	1/735	17/18367	0.500721532190995	0.802839572046619	FDPS	1
GO:0017081	chloride channel regulator activity	1/735	17/18367	0.500721532190995	0.802839572046619	VAMP8	1
GO:0031420	alkali metal ion binding	1/735	17/18367	0.500721532190995	0.802839572046619	PKM	1
GO:0031489	myosin V binding	1/735	17/18367	0.500721532190995	0.802839572046619	RAB25	1
GO:0034185	apolipoprotein binding	1/735	17/18367	0.500721532190995	0.802839572046619	HSPD1	1
GO:0046965	retinoid X receptor binding	1/735	17/18367	0.500721532190995	0.802839572046619	HMGA1	1
GO:0050780	dopamine receptor binding	1/735	17/18367	0.500721532190995	0.802839572046619	GNAS	1
GO:0052745	inositol phosphate phosphatase activity	1/735	17/18367	0.500721532190995	0.802839572046619	IMPA2	1
GO:0072341	modified amino acid binding	4/735	93/18367	0.513782171606685	0.809604101754424	TYMS/HMGB1/DHFR/ANXA2	4
GO:0008080	N-acetyltransferase activity	3/735	68/18367	0.515454490143672	0.809604101754424	HAT1/TAF9/NAA10	3
GO:0061135	endopeptidase regulator activity	8/735	194/18367	0.516350915047056	0.809604101754424	PTTG1/GAPDH/BIRC5/PEBP1/ANXA2/PRDX5/PRDX3/PSMD14	8
GO:0016504	peptidase activator activity	2/735	43/18367	0.517954801495697	0.809604101754424	CAV1/PSMD14	2
GO:0016790	thiolester hydrolase activity	2/735	43/18367	0.517954801495697	0.809604101754424	PNKD/ESD	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/735	43/18367	0.517954801495697	0.809604101754424	PHLDA3/SNX3	2
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/735	18/18367	0.520719879539203	0.809604101754424	HSD17B10	1
GO:0004708	MAP kinase kinase activity	1/735	18/18367	0.520719879539203	0.809604101754424	PBK	1
GO:0008409	5'-3' exonuclease activity	1/735	18/18367	0.520719879539203	0.809604101754424	FEN1	1
GO:0033549	MAP kinase phosphatase activity	1/735	18/18367	0.520719879539203	0.809604101754424	DUSP9	1
GO:0048038	quinone binding	1/735	18/18367	0.520719879539203	0.809604101754424	VKORC1	1
GO:0098918	structural constituent of synapse	1/735	18/18367	0.520719879539203	0.809604101754424	ACTG1	1
GO:0140597	protein carrier activity	1/735	18/18367	0.520719879539203	0.809604101754424	TIMM10	1
GO:0001098	basal transcription machinery binding	3/735	70/18367	0.535092995534139	0.82597585401021	EDF1/FBL/RUVBL1	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/735	70/18367	0.535092995534139	0.82597585401021	EDF1/FBL/RUVBL1	3
GO:0004860	protein kinase inhibitor activity	3/735	70/18367	0.535092995534139	0.82597585401021	NPM1/PKIB/CDKN2A	3
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	12/735	299/18367	0.537574648096747	0.82597585401021	PCNA/NPM1/HMGA1/YWHAH/PARK7/CDKN2A/GTF2A2/APEX1/PARP1/PHB2/MKKS/BUD31	12
GO:0005326	neurotransmitter transmembrane transporter activity	1/735	19/18367	0.539918249397979	0.82597585401021	SLC29A1	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/735	19/18367	0.539918249397979	0.82597585401021	DHFR	1
GO:0030627	pre-mRNA 5'-splice site binding	1/735	19/18367	0.539918249397979	0.82597585401021	SNRPC	1
GO:0140223	general transcription initiation factor activity	2/735	45/18367	0.542545585468658	0.827659316971327	GTF2A2/TAF9	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/735	71/18367	0.544741289580828	0.827659316971327	HINT1/HINT2/NIT2	3
GO:0048029	monosaccharide binding	3/735	71/18367	0.544741289580828	0.827659316971327	ALDOA/TALDO1/UGP2	3
GO:0008170	N-methyltransferase activity	4/735	97/18367	0.547162190237379	0.829448138382572	EZH2/METTL5/FBL/PRMT1	4
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/735	20/18367	0.558348600754666	0.836895543153623	EZH2	1
GO:0004551	nucleotide diphosphatase activity	1/735	20/18367	0.558348600754666	0.836895543153623	NUDT15	1
GO:0016408	C-acyltransferase activity	1/735	20/18367	0.558348600754666	0.836895543153623	ACAT2	1
GO:0030296	protein tyrosine kinase activator activity	1/735	20/18367	0.558348600754666	0.836895543153623	CD24	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/735	20/18367	0.558348600754666	0.836895543153623	GNAS	1
GO:0033293	monocarboxylic acid binding	3/735	73/18367	0.563682866741174	0.842996574251934	GSTP1/NDUFAB1/ADH5	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/735	47/18367	0.566250344413879	0.843055758312628	CDKN3/DUSP9	2
GO:0035254	glutamate receptor binding	2/735	47/18367	0.566250344413879	0.843055758312628	CALM1/GNAS	2
GO:0019210	kinase inhibitor activity	3/735	74/18367	0.572971624113433	0.848832824954447	NPM1/PKIB/CDKN2A	3
GO:0061134	peptidase regulator activity	9/735	230/18367	0.575039625575757	0.848832824954447	PTTG1/GAPDH/BIRC5/PEBP1/ANXA2/PRDX5/PRDX3/CAV1/PSMD14	9
GO:0070577	lysine-acetylated histone binding	1/735	21/18367	0.576041617511918	0.848832824954447	YEATS4	1
GO:0140033	acetylation-dependent protein binding	1/735	21/18367	0.576041617511918	0.848832824954447	YEATS4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/735	48/18367	0.577766270658649	0.848832824954447	PAICS/GMPS	2
GO:0120013	lipid transfer activity	2/735	48/18367	0.577766270658649	0.848832824954447	PRELID1/TRIAP1	2
GO:0004866	endopeptidase inhibitor activity	7/735	180/18367	0.584498827914047	0.856836743337735	PTTG1/GAPDH/BIRC5/PEBP1/ANXA2/PRDX5/PRDX3	7
GO:0004725	protein tyrosine phosphatase activity	4/735	102/18367	0.587140398616572	0.858821591836082	CDKN3/PGP/DUSP9/ACP1	4
GO:0001618	virus receptor activity	3/735	76/18367	0.591175437013707	0.861762197056436	CDK1/RPSA/SIVA1	3
GO:0008320	protein transmembrane transporter activity	1/735	22/18367	0.59302675929371	0.861762197056436	TOMM40	1
GO:0016881	acid-amino acid ligase activity	1/735	22/18367	0.59302675929371	0.861762197056436	PAICS	1
GO:0140272	exogenous protein binding	3/735	77/18367	0.600087270731756	0.868287861121734	CDK1/RPSA/SIVA1	3
GO:0005048	signal sequence binding	2/735	50/18367	0.600120995467945	0.868287861121734	KPNA2/SRP14	2
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/735	23/18367	0.609332310229612	0.877807021432291	PARP1	1
GO:0070412	R-SMAD binding	1/735	23/18367	0.609332310229612	0.877807021432291	PARP1	1
GO:0031593	polyubiquitin modification-dependent protein binding	2/735	52/18367	0.621572080185501	0.888838547989497	PSMD4/RAD23A	2
GO:0030414	peptidase inhibitor activity	7/735	187/18367	0.624751846010463	0.888838547989497	PTTG1/GAPDH/BIRC5/PEBP1/ANXA2/PRDX5/PRDX3	7
GO:1902936	phosphatidylinositol bisphosphate binding	4/735	107/18367	0.624984205471223	0.888838547989497	PFN1/ANXA2/PHLDA3/SNX3	4
GO:0015295	solute:proton symporter activity	1/735	24/18367	0.624985425797712	0.888838547989497	SLC25A3	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/735	24/18367	0.624985425797712	0.888838547989497	GAPDH	1
GO:0070840	dynein complex binding	1/735	24/18367	0.624985425797712	0.888838547989497	SMC3	1
GO:0008266	poly(U) RNA binding	1/735	25/18367	0.64001217780331	0.904423988548321	SSB	1
GO:0035035	histone acetyltransferase binding	1/735	25/18367	0.64001217780331	0.904423988548321	PCNA	1
GO:0051019	mitogen-activated protein kinase binding	1/735	25/18367	0.64001217780331	0.904423988548321	PRMT1	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/735	82/18367	0.64269864194255	0.906300199102919	PFN1/ANXA2/PHLDA3	3
GO:0008198	ferrous iron binding	1/735	26/18367	0.654437597567489	0.915115047332317	ISCU	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/735	26/18367	0.654437597567489	0.915115047332317	ZDHHC12	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/735	26/18367	0.654437597567489	0.915115047332317	ZDHHC12	1
GO:0042974	retinoic acid receptor binding	1/735	26/18367	0.654437597567489	0.915115047332317	HMGA1	1
GO:0050840	extracellular matrix binding	2/735	56/18367	0.661784417624459	0.917133946670234	RPSA/ANXA2	2
GO:0001671	ATPase activator activity	1/735	27/18367	0.668285717396718	0.917133946670234	AHSA1	1
GO:0008139	nuclear localization sequence binding	1/735	27/18367	0.668285717396718	0.917133946670234	KPNA2	1
GO:0016866	intramolecular transferase activity	1/735	27/18367	0.668285717396718	0.917133946670234	PGAM1	1
GO:0035255	ionotropic glutamate receptor binding	1/735	27/18367	0.668285717396718	0.917133946670234	GNAS	1
GO:0051393	alpha-actinin binding	1/735	27/18367	0.668285717396718	0.917133946670234	PDLIM1	1
GO:0051959	dynein light intermediate chain binding	1/735	27/18367	0.668285717396718	0.917133946670234	DYNLL1	1
GO:0070006	metalloaminopeptidase activity	1/735	27/18367	0.668285717396718	0.917133946670234	METAP2	1
GO:0005548	phospholipid transporter activity	2/735	57/18367	0.671284802835721	0.917133946670234	PRELID1/TRIAP1	2
GO:0003774	cytoskeletal motor activity	4/735	114/18367	0.674123338087172	0.917133946670234	MYL6/DYNLRB1/PIN1/SMC3	4
GO:0101005	deubiquitinase activity	4/735	114/18367	0.674123338087172	0.917133946670234	EIF3F/PSMD14/EIF3H/USP1	4
GO:0003785	actin monomer binding	1/735	28/18367	0.681579610401812	0.917133946670234	PFN1	1
GO:0008187	poly-pyrimidine tract binding	1/735	28/18367	0.681579610401812	0.917133946670234	SSB	1
GO:0015101	organic cation transmembrane transporter activity	1/735	28/18367	0.681579610401812	0.917133946670234	SLC29A1	1
GO:0017056	structural constituent of nuclear pore	1/735	28/18367	0.681579610401812	0.917133946670234	NUTF2	1
GO:0043236	laminin binding	1/735	28/18367	0.681579610401812	0.917133946670234	RPSA	1
GO:0050681	androgen receptor binding	1/735	28/18367	0.681579610401812	0.917133946670234	PARK7	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/735	28/18367	0.681579610401812	0.917133946670234	SKP1	1
GO:0005253	anion channel activity	3/735	87/18367	0.682006652996156	0.917133946670234	VDAC1/VDAC3/VDAC2	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/735	59/18367	0.689635333191164	0.924402660607081	FEN1/APEX1	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/735	29/18367	0.694341428731855	0.924402660607081	AKR1B1	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/735	29/18367	0.694341428731855	0.924402660607081	DHFR	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/735	29/18367	0.694341428731855	0.924402660607081	PHLDA3	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/735	29/18367	0.694341428731855	0.924402660607081	SNX3	1
GO:0043178	alcohol binding	3/735	89/18367	0.696800968280429	0.925829174986148	VDAC1/CAV1/VDAC2	3
GO:0001786	phosphatidylserine binding	2/735	60/18367	0.698489984369262	0.926228269531407	HMGB1/ANXA2	2
GO:0016417	S-acyltransferase activity	1/735	30/18367	0.706592440286118	0.930371832357851	ZDHHC12	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/735	30/18367	0.706592440286118	0.930371832357851	HSD17B10	1
GO:0031406	carboxylic acid binding	6/735	176/18367	0.711258790087306	0.930371832357851	TYMS/GSTP1/DHFR/NDUFAB1/ADH5/GRHPR	6
GO:1990841	promoter-specific chromatin binding	2/735	62/18367	0.715570532356559	0.930371832357851	EZH2/DNMT1	2
GO:0051213	dioxygenase activity	3/735	92/18367	0.718005457679004	0.930371832357851	ADI1/ETHE1/PIR	3
GO:0000146	microfilament motor activity	1/735	31/18367	0.718353063964458	0.930371832357851	MYL6	1
GO:0005164	tumor necrosis factor receptor binding	1/735	31/18367	0.718353063964458	0.930371832357851	SIVA1	1
GO:0008157	protein phosphatase 1 binding	1/735	31/18367	0.718353063964458	0.930371832357851	PPP1CA	1
GO:0016878	acid-thiol ligase activity	1/735	31/18367	0.718353063964458	0.930371832357851	SUCLG1	1
GO:0043015	gamma-tubulin binding	1/735	31/18367	0.718353063964458	0.930371832357851	NME1	1
GO:0071813	lipoprotein particle binding	1/735	31/18367	0.718353063964458	0.930371832357851	HSPD1	1
GO:0071814	protein-lipid complex binding	1/735	31/18367	0.718353063964458	0.930371832357851	HSPD1	1
GO:0019903	protein phosphatase binding	5/735	150/18367	0.721852525961193	0.932321487823843	SOD1/RPA2/PPP1CA/SNX3/ENSA	5
GO:0005506	iron ion binding	5/735	151/18367	0.727216638121777	0.932321487823843	RRM2/NFU1/ADI1/ETHE1/ISCU	5
GO:0001222	transcription corepressor binding	1/735	32/18367	0.729642903514312	0.932321487823843	EZH2	1
GO:0050699	WW domain binding	1/735	32/18367	0.729642903514312	0.932321487823843	TCEAL8	1
GO:0051721	protein phosphatase 2A binding	1/735	32/18367	0.729642903514312	0.932321487823843	ENSA	1
GO:0071889	14-3-3 protein binding	1/735	32/18367	0.729642903514312	0.932321487823843	YWHAQ	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/735	32/18367	0.729642903514312	0.932321487823843	HELLS	1
GO:0016410	N-acyltransferase activity	3/735	94/18367	0.731491279329964	0.932896144002076	HAT1/TAF9/NAA10	3
GO:1901681	sulfur compound binding	9/735	265/18367	0.738104696345325	0.933745164806763	PPIA/GSTP1/RPL29/RPL22/DBI/PDCD5/ACBD6/METTL5/PRMT1	9
GO:0008173	RNA methyltransferase activity	2/735	65/18367	0.739660860260045	0.933745164806763	METTL5/FBL	2
GO:0030145	manganese ion binding	2/735	65/18367	0.739660860260045	0.933745164806763	FEN1/NUDT8	2
GO:0004623	phospholipase A2 activity	1/735	33/18367	0.7404807800301	0.933745164806763	PRDX6	1
GO:0019956	chemokine binding	1/735	33/18367	0.7404807800301	0.933745164806763	HMGB1	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4/735	125/18367	0.741956427807472	0.933745164806763	HINT1/HINT2/ATIC/NIT2	4
GO:0019783	ubiquitin-like protein-specific protease activity	4/735	125/18367	0.741956427807472	0.933745164806763	EIF3F/PSMD14/EIF3H/USP1	4
GO:0016229	steroid dehydrogenase activity	1/735	34/18367	0.750884763158598	0.941428828997716	HSD17B10	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/735	34/18367	0.750884763158598	0.941428828997716	CALM1	1
GO:0008017	microtubule binding	9/735	271/18367	0.761260345719673	0.952646624005669	NUSAP1/GAPDH/BIRC5/PRC1/RPS3/TPX2/SKA2/CNN3/UXT	9
GO:0016887	ATP hydrolysis activity	9/735	272/18367	0.764975999699642	0.95519823923285	MCM7/MCM5/HSPD1/HSP90AA1/MCM4/OLA1/MCM3/DDX39A/RUVBL1	9
GO:0005496	steroid binding	3/735	100/18367	0.768906581543133	0.95519823923285	VDAC1/CAV1/VDAC2	3
GO:0003777	microtubule motor activity	2/735	69/18367	0.769050681359823	0.95519823923285	DYNLRB1/SMC3	2
GO:0005484	SNAP receptor activity	1/735	36/18367	0.770459749186317	0.95519823923285	VAMP8	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/735	36/18367	0.770459749186317	0.95519823923285	ATIC	1
GO:0140030	modification-dependent protein binding	5/735	160/18367	0.772144762741118	0.955511237009881	HSPD1/PSMD4/CBX5/YEATS4/RAD23A	5
GO:0016791	phosphatase activity	9/735	275/18367	0.775877136968002	0.957708078068518	CDKN3/PHPT1/PPP1CA/PGP/IMPA2/DUSP9/PPM1G/ACP1/PPP4C	9
GO:0016409	palmitoyltransferase activity	1/735	37/18367	0.779663397887864	0.957708078068518	ZDHHC12	1
GO:0043531	ADP binding	1/735	37/18367	0.779663397887864	0.957708078068518	RUVBL1	1
GO:0071855	neuropeptide receptor binding	1/735	37/18367	0.779663397887864	0.957708078068518	GNAS	1
GO:0019213	deacetylase activity	1/735	38/18367	0.788498498954553	0.966408740466933	ESD	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	7/735	222/18367	0.789644323170133	0.966408740466933	ACAT2/PRDX6/HAT1/PAFAH1B3/TAF9/NAA10/ZDHHC12	7
GO:0002020	protease binding	4/735	135/18367	0.793812688789649	0.968279636879346	PARK7/ANXA2/SUMO1/RAD23A	4
GO:0016874	ligase activity	5/735	165/18367	0.794547225991806	0.968279636879346	PAICS/GMPS/SAE1/NAE1/SUCLG1	5
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	1/735	39/18367	0.796979791074604	0.968279636879346	PHLDA3	1
GO:0019825	oxygen binding	1/735	39/18367	0.796979791074604	0.968279636879346	PARK7	1
GO:0019902	phosphatase binding	6/735	196/18367	0.801080436966857	0.969342942240085	CARHSP1/SOD1/RPA2/PPP1CA/SNX3/ENSA	6
GO:0017022	myosin binding	2/735	74/18367	0.80169055407886	0.969342942240085	MYL12B/RAB25	2
GO:0003925	G protein activity	1/735	40/18367	0.805121424289366	0.969342942240085	HRAS	1
GO:0004177	aminopeptidase activity	1/735	40/18367	0.805121424289366	0.969342942240085	METAP2	1
GO:0017080	sodium channel regulator activity	1/735	40/18367	0.805121424289366	0.969342942240085	YWHAH	1
GO:0020037	heme binding	4/735	139/18367	0.81206893536908	0.975945909713831	CYB5A/CYCS/CYC1/CYB5B	4
GO:0019894	kinesin binding	1/735	42/18367	0.820439510873232	0.982764963519478	PRC1	1
GO:0019838	growth factor binding	4/735	141/18367	0.820689782129459	0.982764963519478	RPS2/RPS19/S100A13/FIBP	4
GO:1901981	phosphatidylinositol phosphate binding	5/735	173/18367	0.826754393072677	0.985780176817923	PFN1/ANXA2/PHLDA2/PHLDA3/SNX3	5
GO:0018024	histone-lysine N-methyltransferase activity	1/735	43/18367	0.827641527763173	0.985780176817923	EZH2	1
GO:0030547	signaling receptor inhibitor activity	1/735	43/18367	0.827641527763173	0.985780176817923	LY6E	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	4/735	144/18367	0.833007437672203	0.98797658729907	PCNA/UNG/DNPH1/APEX1	4
GO:0001784	phosphotyrosine residue binding	1/735	44/18367	0.834555055218645	0.98797658729907	PFN1	1
GO:0004527	exonuclease activity	2/735	80/18367	0.835404134472463	0.98797658729907	FEN1/APEX1	2
GO:0004843	thiol-dependent deubiquitinase	3/735	113/18367	0.835410487611207	0.98797658729907	EIF3F/PSMD14/USP1	3
GO:0046906	tetrapyrrole binding	4/735	149/18367	0.851964998003936	0.999999993572007	CYB5A/CYCS/CYC1/CYB5B	4
GO:0008013	beta-catenin binding	2/735	85/18367	0.859446342216321	0.999999993572007	SKP1/PIN1	2
GO:0032813	tumor necrosis factor receptor superfamily binding	1/735	49/18367	0.86518352373294	0.999999993572007	SIVA1	1
GO:0008514	organic anion transmembrane transporter activity	5/735	185/18367	0.867267253994155	0.999999993572007	SLC25A5/SLC25A6/MPC2/SLC29A1/SLC25A1	5
GO:0051015	actin filament binding	6/735	217/18367	0.87041087412727	0.999999993572007	CFL1/DSTN/CTNNAL1/ARPC1A/ARPC5/ARPC5L	6
GO:0051018	protein kinase A binding	1/735	51/18367	0.875785635036606	0.999999993572007	RPS3	1
GO:0015297	antiporter activity	2/735	89/18367	0.876319693234737	0.999999993572007	SLC25A5/SLC25A6	2
GO:0016746	acyltransferase activity	7/735	250/18367	0.876932649761598	0.999999993572007	ACAT2/PRDX6/HAT1/PAFAH1B3/TAF9/NAA10/ZDHHC12	7
GO:0060090	molecular adaptor activity	11/735	369/18367	0.877296716949692	0.999999993572007	AP2S1/PSMG1/CAV1/VAMP8/SKP1/POLD3/PSMG2/CBX5/AP1S1/AP1M2/ISCU	11
GO:0140101	catalytic activity, acting on a tRNA	3/735	124/18367	0.878126995974612	0.999999993572007	POP7/TSEN34/RPP30	3
GO:0008242	omega peptidase activity	3/735	126/18367	0.884741806712195	0.999999993572007	EIF3F/PSMD14/USP1	3
GO:0008374	O-acyltransferase activity	1/735	54/18367	0.890148076318996	0.999999993572007	PRDX6	1
GO:0008408	3'-5' exonuclease activity	1/735	54/18367	0.890148076318996	0.999999993572007	APEX1	1
GO:0005543	phospholipid binding	14/735	466/18367	0.895346004672209	0.999999993572007	HMGB1/PFN1/ANXA5/PEBP1/VDAC1/ANXA2/ANXA3/PHLDA2/STOML2/VDAC2/PHLDA3/SNX3/NME4/NSFL1C	14
GO:0005539	glycosaminoglycan binding	6/735	230/18367	0.902280356797945	0.999999993572007	PPIA/RPL29/RPL22/HMMR/PDCD5/C1QBP	6
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/735	58/18367	0.906751560009141	0.999999993572007	MPC2	1
GO:0004867	serine-type endopeptidase inhibitor activity	2/735	98/18367	0.90767079663657	0.999999993572007	PEBP1/ANXA2	2
GO:0030674	protein-macromolecule adaptor activity	8/735	296/18367	0.909846898213686	0.999999993572007	AP2S1/CAV1/VAMP8/SKP1/POLD3/CBX5/AP1S1/AP1M2	8
GO:0016279	protein-lysine N-methyltransferase activity	1/735	59/18367	0.91049494323014	0.999999993572007	EZH2	1
GO:0043177	organic acid binding	3/735	135/18367	0.910703123677137	0.999999993572007	TYMS/DHFR/ID3	3
GO:0016278	lysine N-methyltransferase activity	1/735	60/18367	0.914088247617613	0.999999993572007	EZH2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/735	60/18367	0.914088247617613	0.999999993572007	AKR1B1	1
GO:0043621	protein self-association	1/735	61/18367	0.917537482227383	0.999999993572007	MDH2	1
GO:0042578	phosphoric ester hydrolase activity	10/735	366/18367	0.924130805066385	0.999999993572007	CDKN3/PHPT1/PPP1CA/PGP/IMPA2/DUSP9/APEX1/PPM1G/ACP1/PPP4C	10
GO:1990782	protein tyrosine kinase binding	2/735	105/18367	0.92673769911018	0.999999993572007	PCNA/HSP90AA1	2
GO:0005178	integrin binding	3/735	144/18367	0.931244052435852	0.999999993572007	HMGB1/PPIA/ITGB1BP1	3
GO:0052689	carboxylic ester hydrolase activity	3/735	147/18367	0.937061609239518	0.999999993572007	PRDX6/PAFAH1B3/ESD	3
GO:0008509	anion transmembrane transporter activity	8/735	314/18367	0.937860934607688	0.999999993572007	SLC25A5/SLC25A6/VDAC1/MPC2/VDAC3/VDAC2/SLC29A1/SLC25A1	8
GO:0016782	transferase activity, transferring sulphur-containing groups	1/735	68/18367	0.938104811409121	0.999999993572007	TSTD1	1
GO:0003779	actin binding	12/735	440/18367	0.940699799783854	0.999999993572007	PFN1/ALDOA/YWHAH/PDLIM1/CFL1/DSTN/CTNNAL1/DIAPH3/ARPC1A/CNN3/ARPC5/ARPC5L	12
GO:0015103	inorganic anion transmembrane transporter activity	3/735	152/18367	0.945756584530674	0.999999993572007	VDAC1/VDAC3/VDAC2	3
GO:0008235	metalloexopeptidase activity	1/735	72/18367	0.947466635517712	0.999999993572007	METAP2	1
GO:0008234	cysteine-type peptidase activity	4/735	190/18367	0.948954251852914	0.999999993572007	EIF3F/PSMD14/EIF3H/USP1	4
GO:0008237	metallopeptidase activity	4/735	190/18367	0.948954251852914	0.999999993572007	EIF3F/PSMD14/EIF3H/METAP2	4
GO:0035064	methylated histone binding	1/735	73/18367	0.949577158769666	0.999999993572007	CBX5	1
GO:0070063	RNA polymerase binding	1/735	73/18367	0.949577158769666	0.999999993572007	ANP32B	1
GO:0140034	methylation-dependent protein binding	1/735	73/18367	0.949577158769666	0.999999993572007	CBX5	1
GO:0019905	syntaxin binding	1/735	74/18367	0.95160300266954	0.999999993572007	VAMP8	1
GO:0003724	RNA helicase activity	1/735	77/18367	0.95720571575939	0.999999993572007	DDX39A	1
GO:0030971	receptor tyrosine kinase binding	1/735	78/18367	0.958925442326741	0.999999993572007	PCNA	1
GO:0008186	ATP-dependent activity, acting on RNA	1/735	79/18367	0.960576150396611	0.999999993572007	DDX39A	1
GO:0046332	SMAD binding	1/735	79/18367	0.960576150396611	0.999999993572007	PARP1	1
GO:0008201	heparin binding	3/735	166/18367	0.964519317456548	0.999999993572007	RPL29/RPL22/PDCD5	3
GO:0030165	PDZ domain binding	1/735	84/18367	0.96788745079216	0.999999993572007	GNG5	1
GO:0050660	flavin adenine dinucleotide binding	1/735	85/18367	0.969178416370444	0.999999993572007	ETFA	1
GO:0008081	phosphoric diester hydrolase activity	1/735	89/18367	0.973844341157804	0.999999993572007	APEX1	1
GO:0019955	cytokine binding	2/735	139/18367	0.977082898075525	0.999999993572007	HMGB1/PARK7	2
GO:0004175	endopeptidase activity	10/735	430/18367	0.97964569568823	0.999999993572007	PSMB2/PSMB1/PSMB6/PSMB3/PSMB5/PSMB7/PSMA4/SEC11A/PSMB4/USP1	10
GO:0019842	vitamin binding	2/735	148/18367	0.983296317300826	0.999999993572007	TYMS/DHFR	2
GO:0004497	monooxygenase activity	1/735	102/18367	0.98466211580872	0.999999993572007	PCBD1	1
GO:0016757	glycosyltransferase activity	5/735	270/18367	0.98486141029173	0.999999993572007	PNP/QPRT/PARP1/APRT/UMPS	5
GO:0035091	phosphatidylinositol binding	5/735	271/18367	0.985278049038142	0.999999993572007	PFN1/ANXA2/PHLDA2/PHLDA3/SNX3	5
GO:0008238	exopeptidase activity	1/735	103/18367	0.985279326040343	0.999999993572007	METAP2	1
GO:0004620	phospholipase activity	1/735	104/18367	0.985871731611978	0.999999993572007	PRDX6	1
GO:0015294	solute:cation symporter activity	1/735	104/18367	0.985871731611978	0.999999993572007	SLC25A3	1
GO:0005319	lipid transporter activity	2/735	154/18367	0.986493792808019	0.999999993572007	PRELID1/TRIAP1	2
GO:0015291	secondary active transmembrane transporter activity	4/735	240/18367	0.98790749648748	0.999999993572007	SLC25A5/SLC25A6/SLC25A3/SLC25A1	4
GO:0005244	voltage-gated ion channel activity	3/735	201/18367	0.988258969252836	0.999999993572007	VDAC1/VDAC3/VDAC2	3
GO:0022832	voltage-gated channel activity	3/735	201/18367	0.988258969252836	0.999999993572007	VDAC1/VDAC3/VDAC2	3
GO:0000149	SNARE binding	1/735	110/18367	0.988958312580521	0.999999993572007	VAMP8	1
GO:0019787	ubiquitin-like protein transferase activity	10/735	458/18367	0.989180286787601	0.999999993572007	UBE2C/UBE2T/ANAPC11/UBE2S/RBX1/SUMO2/UBE2L3/UBE2N/UBE2I/UFC1	10
GO:0046943	carboxylic acid transmembrane transporter activity	2/735	163/18367	0.99020212068333	0.999999993572007	MPC2/SLC25A1	2
GO:0005342	organic acid transmembrane transporter activity	2/735	164/18367	0.990546902862301	0.999999993572007	MPC2/SLC25A1	2
GO:0004197	cysteine-type endopeptidase activity	1/735	119/18367	0.992372400897112	0.999999993572007	USP1	1
GO:0005262	calcium channel activity	1/735	119/18367	0.992372400897112	0.999999993572007	ANXA2	1
GO:0001664	G protein-coupled receptor binding	5/735	295/18367	0.992562433855608	0.999999993572007	CALM1/GNAS/C1QBP/PSMC5/PHB	5
GO:0004714	transmembrane receptor protein tyrosine kinase activity	1/735	124/18367	0.99378981917481	0.999999993572007	PBK	1
GO:0005085	guanyl-nucleotide exchange factor activity	3/735	223/18367	0.994294765747533	0.999999993572007	EEF1B2/EEF1D/ECT2	3
GO:0016298	lipase activity	1/735	129/18367	0.99494413290126	0.999999993572007	PRDX6	1
GO:0017124	SH3 domain binding	1/735	130/18367	0.995147886729398	0.999999993572007	PTTG1	1
GO:0004674	protein serine/threonine kinase activity	7/735	386/18367	0.995268723533905	0.999999993572007	CDK1/PBK/AURKB/AURKA/VRK1/CSNK2B/CDK4	7
GO:0015085	calcium ion transmembrane transporter activity	1/735	135/18367	0.996050043295368	0.999999993572007	ANXA2	1
GO:0004713	protein tyrosine kinase activity	1/735	136/18367	0.996209280799641	0.999999993572007	PBK	1
GO:0106310	protein serine kinase activity	6/735	360/18367	0.996555700722796	0.999999993572007	CDK1/PBK/AURKB/AURKA/VRK1/CDK4	6
GO:0019199	transmembrane receptor protein kinase activity	1/735	143/18367	0.997158167039397	0.999999993572007	PBK	1
GO:0015293	symporter activity	1/735	144/18367	0.997272782229588	0.999999993572007	SLC25A3	1
GO:0005516	calmodulin binding	2/735	201/18367	0.997536518869939	0.999999993572007	EDF1/CNN3	2
GO:0008083	growth factor activity	1/735	162/18367	0.998700634544091	0.999999993572007	NENF	1
GO:0004842	ubiquitin-protein transferase activity	7/735	433/18367	0.998718213625562	0.999999993572007	UBE2C/UBE2T/ANAPC11/UBE2S/RBX1/UBE2L3/UBE2N	7
GO:0005126	cytokine receptor binding	3/735	271/18367	0.998881251501065	0.999999993572007	MIF/SIVA1/DDT	3
GO:0030246	carbohydrate binding	3/735	271/18367	0.998881251501065	0.999999993572007	ALDOA/TALDO1/UGP2	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/735	170/18367	0.999065625494941	0.999999993572007	PCBD1	1
GO:0004252	serine-type endopeptidase activity	1/735	174/18367	0.999207696258161	0.999999993572007	SEC11A	1
GO:0005125	cytokine activity	2/735	235/18367	0.999303238677905	0.999999993572007	HMGB1/MIF	2
GO:0008236	serine-type peptidase activity	1/735	191/18367	0.999607094756852	0.999999993572007	SEC11A	1
GO:0061630	ubiquitin protein ligase activity	3/735	304/18367	0.999647417956987	0.999999993572007	UBE2C/ANAPC11/RBX1	3
GO:0017171	serine hydrolase activity	1/735	195/18367	0.99966690044374	0.999999993572007	SEC11A	1
GO:0061659	ubiquitin-like protein ligase activity	3/735	316/18367	0.99976965249224	0.999999993572007	UBE2C/ANAPC11/RBX1	3
GO:0022836	gated channel activity	3/735	340/18367	0.999902488821839	0.999999993572007	VDAC1/VDAC3/VDAC2	3
GO:0015267	channel activity	6/735	480/18367	0.999909334206913	0.999999993572007	VDAC1/ANXA2/VDAC3/VDAC2/TOMM40/BAX	6
GO:0022803	passive transmembrane transporter activity	6/735	481/18367	0.999912174334211	0.999999993572007	VDAC1/ANXA2/VDAC3/VDAC2/TOMM40/BAX	6
GO:0005216	ion channel activity	4/735	432/18367	0.999978474880397	0.999999993572007	VDAC1/ANXA2/VDAC3/VDAC2	4
GO:0030695	GTPase regulator activity	5/735	488/18367	0.999983930890624	0.999999993572007	RANBP1/EEF1B2/EEF1D/ECT2/ITGB1BP1	5
GO:0060589	nucleoside-triphosphatase regulator activity	5/735	488/18367	0.999983930890624	0.999999993572007	RANBP1/EEF1B2/EEF1D/ECT2/ITGB1BP1	5
GO:0005096	GTPase activator activity	4/735	462/18367	0.999992547641907	0.999999993572007	RANBP1/EEF1B2/EEF1D/ECT2	4
GO:0048018	receptor ligand activity	4/735	487/18367	0.999996952601623	0.999999993572007	HMGB2/HMGB1/MIF/NENF	4
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	1/735	310/18367	0.999997156313662	0.999999993572007	ENO1	1
GO:0001217	DNA-binding transcription repressor activity	1/735	313/18367	0.999997489640393	0.999999993572007	ENO1	1
GO:0030546	signaling receptor activator activity	4/735	495/18367	0.99999771519325	0.999999993572007	HMGB2/HMGB1/MIF/NENF	4
GO:0005261	cation channel activity	1/735	335/18367	0.999998994490557	0.999999993572007	ANXA2	1
GO:0046873	metal ion transmembrane transporter activity	1/735	430/18367	0.999999980907868	0.999999993572007	ANXA2	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	1/735	450/18367	0.999999991735046	0.999999993572007	TFDP1	1
GO:0001216	DNA-binding transcription activator activity	1/735	456/18367	0.999999993572007	0.999999993572007	TFDP1	1