ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0005201	extracellular matrix structural constituent	57/822	172/18367	2.68272739702613e-34	2.24276010391385e-31	DCN/LUM/COL3A1/COL1A1/COL1A2/COL6A1/COL6A2/COL15A1/CTHRC1/MATN2/COL5A1/AEBP1/SRPX/HAPLN1/LAMA2/COL6A3/FBLN2/MGP/MFAP4/NID1/SBSPON/TNXB/FMOD/FBLN5/LTBP4/SPON1/PCOLCE/LAMA4/ECM1/ELN/VTN/ABI3BP/COL11A1/COL16A1/EFEMP2/DPT/EMILIN1/COL8A2/PODN/TGFBI/NID2/LTBP2/VCAN/SPARC/MFAP2/COL5A2/THBS1/MFGE8/COL4A1/COL14A1/COL4A2/LAMC1/LAMB2/HSPG2/LAMB1/FBN1/FBLN1	57
GO:0019838	growth factor binding	35/822	141/18367	5.18589235856872e-17	2.16770300588173e-14	IGFBP3/COL3A1/COL1A1/COL1A2/COL6A1/PDGFRA/COL5A1/IGFBP2/IGFBP5/LTBP4/PDGFRB/VASN/CD36/LTBP2/THBS1/OSMR/FGFR1/IL1R1/COL4A1/IL6ST/TWSG1/ACVR2A/TGFBR3/HTRA1/NRP2/A2M/TGFBR2/ENG/PCSK6/BMPR2/LTBP3/LIFR/IGF2R/SORT1/CRIM1	35
GO:0005518	collagen binding	24/822	69/18367	1.02034111220881e-15	2.84335056602187e-13	DCN/LUM/COL6A1/COL6A2/AEBP1/NID1/TNXB/ANTXR1/PCOLCE/DDR2/PODN/TGFBI/NID2/SPARC/MRC2/ITGA1/THBS1/CTSK/COL14A1/PCOLCE2/SERPINH1/CRTAP/ITGB1/P3H4	24
GO:0005178	integrin binding	33/822	144/18367	5.11157966847479e-15	8.94269900014498e-13	COL3A1/EGFL6/COL5A1/VCAM1/ADAMTS5/TNXB/FBLN5/LTBP4/FAP/ITGBL1/THY1/VTN/COL16A1/EMILIN1/TGFBI/THBS1/MFGE8/PRKCA/PLPP3/IGF2/TSPAN4/CD9/CD81/DST/LAMB2/GPNMB/ITGB1/LAMB1/FBN1/CD151/TIMP2/FBLN1/ACTN4	33
GO:0005539	glycosaminoglycan binding	42/822	230/18367	5.34850418668958e-15	8.94269900014498e-13	DCN/FGF7/COL5A1/HAPLN1/CRISPLD2/ADAMTS5/TNXB/SLIT2/LTBP4/PCOLCE/VTN/RSPO3/COL11A1/SLIT3/EFEMP2/SMOC2/RSPO2/DPYSL3/ADAMTS15/BMP4/LTBP2/VCAN/SERPINE2/THBS1/APOE/FGFR1/ADAMTS1/SOD3/PCOLCE2/TGFBR3/CCDC80/GPNMB/MDK/NRP2/FSTL1/PRNP/TGFBR2/SULF2/ENG/FBN1/PCSK6/NAV2	42
GO:0008201	heparin binding	33/822	166/18367	3.84083578950009e-13	5.35156453337013e-11	FGF7/COL5A1/CRISPLD2/ADAMTS5/TNXB/SLIT2/PCOLCE/VTN/RSPO3/COL11A1/SLIT3/EFEMP2/SMOC2/RSPO2/ADAMTS15/BMP4/LTBP2/SERPINE2/THBS1/APOE/FGFR1/ADAMTS1/SOD3/PCOLCE2/TGFBR3/CCDC80/GPNMB/MDK/NRP2/FSTL1/FBN1/PCSK6/NAV2	33
GO:0003779	actin binding	55/822	440/18367	5.12956410921106e-12	6.1261651361435e-10	ANTXR1/SYNPO2/MAP1B/PLEKHH2/MYO1B/LMOD1/TAGLN/TPM2/EPB41L2/MYLK/KCNMA1/PHACTR2/FSCN1/BIN1/PLS3/MARCKS/GAS7/NEXN/MYO10/CALD1/FLNA/PALLD/SPTBN1/NEBL/MYO1E/CFL2/PDLIM7/TNS1/DST/ENAH/CNN3/PDLIM5/S100A4/LSP1/FMNL2/PXK/ITGB1/EPS8/TPM4/CNN2/ABL1/SNTB2/PLEC/TPM1/LASP1/SYNE1/VCL/WASL/MYO1C/MSN/CCDC88A/GSN/MACF1/ACTN4/DAAM1	55
GO:1901681	sulfur compound binding	39/822	265/18367	5.43966841506483e-11	5.68445349374274e-09	ENPP1/FGF7/COL5A1/CRISPLD2/ADAMTS5/TNXB/SLIT2/PCOLCE/VTN/RSPO3/FST/COL11A1/SLIT3/EFEMP2/SMOC2/RSPO2/DPYSL3/ADAMTS15/BMP4/LTBP2/SERPINE2/THBS1/APOE/FGFR1/ADAMTS1/SOD3/PCOLCE2/TGFBR3/CCDC80/GPNMB/MDK/LRP1/NRP2/FSTL1/FBN1/PCSK6/NAV2/GSTM3/PANK3	39
GO:0030020	extracellular matrix structural constituent conferring tensile strength	15/822	41/18367	1.08862720323568e-10	1.01121371322781e-08	COL3A1/COL1A1/COL1A2/COL6A1/COL6A2/COL15A1/COL5A1/COL6A3/COL11A1/COL16A1/COL8A2/COL5A2/COL4A1/COL14A1/COL4A2	15
GO:0050840	extracellular matrix binding	16/822	56/18367	1.7384880208466e-09	1.45337598542776e-07	DCN/FBLN2/NID1/ADAMTS5/SLIT2/ECM1/ELN/COL11A1/SMOC2/CD248/ADAMTS15/TGFBI/SPARC/THBS1/LGALS1/ITGB1	16
GO:0048407	platelet-derived growth factor binding	8/822	11/18367	2.27831192895658e-09	1.731517066007e-07	COL3A1/COL1A1/COL1A2/COL6A1/PDGFRA/COL5A1/PDGFRB/COL4A1	8
GO:0019955	cytokine binding	23/822	139/18367	5.45165230292457e-08	3.79798443770411e-06	PDPN/LTBP4/ACKR1/VASN/CD36/THBS1/OSMR/IL1R1/PRLR/IL6ST/TWSG1/TGFBR3/PLP2/NRP2/A2M/TGFBR2/ENG/TNFRSF1A/ITGB1/BMPR2/LTBP3/LIFR/IFNAR1	23
GO:0097493	structural molecule activity conferring elasticity	7/822	11/18367	9.8847238985842e-08	6.35663783016645e-06	FBLN2/FBLN5/ELN/EMILIN1/LAMC1/AHNAK/FBN1	7
GO:0046332	SMAD binding	16/822	79/18367	3.42954857582526e-07	2.04793043527851e-05	COL1A2/CREB3L1/GATA4/COL5A2/LDLRAD4/FLNA/TGFBR3/SMAD5/TGFBR2/SKIL/PURA/DAB2/SKI/TCF12/ZMIZ1/USP9X	16
GO:0050431	transforming growth factor beta binding	9/822	24/18367	4.91439790955503e-07	2.73895776825867e-05	LTBP4/VASN/CD36/THBS1/TWSG1/TGFBR3/TGFBR2/ENG/LTBP3	9
GO:0002020	protease binding	21/822	135/18367	5.96211347327718e-07	3.11520428978733e-05	COL3A1/COL1A1/COL1A2/F3/FAP/ECM1/IL1R1/TIMP1/BIN1/PTEN/TIMP3/LRP1/DPP4/A2M/SH3PXD2A/PRNP/ITGB1/TIMP2/AMFR/CLTC/SERPINB9	21
GO:0051015	actin filament binding	26/822	217/18367	4.86412674439455e-06	0.000239200585783167	ANTXR1/MYO1B/TAGLN/TPM2/FSCN1/BIN1/PLS3/MARCKS/GAS7/NEXN/MYO10/FLNA/SPTBN1/NEBL/MYO1E/CFL2/FMNL2/TPM4/ABL1/TPM1/LASP1/SYNE1/MYO1C/GSN/MACF1/ACTN4	26
GO:0019199	transmembrane receptor protein kinase activity	19/822	143/18367	2.11900445754889e-05	0.000959543246483058	PDGFRA/LTBP4/DDR2/PDGFRB/EPHA3/FGFR1/ACVR2A/TGFBR3/NRP2/AXL/TGFBR2/ENG/BMPR2/ABL1/DSTYK/IGF2R/FER/CRIM1/JAK1	19
GO:0043394	proteoglycan binding	9/822	36/18367	2.18078010564331e-05	0.000959543246483058	COL5A1/NID1/SLIT2/FST/THBS1/APOE/CTSK/GPNMB/LRP1	9
GO:0030021	extracellular matrix structural constituent conferring compression resistance	7/822	22/18367	3.31208345950727e-05	0.00138445088607404	DCN/LUM/HAPLN1/FMOD/PODN/VCAN/HSPG2	7
GO:0045296	cadherin binding	31/822	332/18367	9.43608287999092e-05	0.00375645966079639	CDH11/STXBP6/VASN/MYO1B/PROM1/PPL/SLC9A3R2/FSCN1/CALD1/FLNA/SPTBN1/CNN3/PDLIM5/FMNL2/AHNAK/NOTCH3/NDRG1/ITGB1/PPFIBP1/BMPR2/CNN2/ARGLU1/PLEC/ASAP1/LASP1/RTN4/TAGLN2/VCL/TJP1/MACF1/ESYT2	31
GO:0005516	calmodulin binding	22/822	201/18367	0.000101331277796742	0.00385058855627618	AEBP1/MYO1B/ADCY3/AKAP12/MYLK/MARCKS/MYO10/CALD1/SPTBN1/CASK/MYO1E/CNN3/CAMK2D/PLCB1/UBR4/CNN2/SNTB2/DAPK1/MYO1C/SLC8A1/TJP1/STRN3	22
GO:0005024	transforming growth factor beta-activated receptor activity	5/822	12/18367	0.000107981227078863	0.00392488286251868	LTBP4/TGFBR3/TGFBR2/ENG/BMPR2	5
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	6/822	19/18367	0.000129627941098369	0.00451537328159319	LTBP4/ACVR2A/TGFBR3/TGFBR2/ENG/BMPR2	6
GO:0030674	protein-macromolecule adaptor activity	28/822	296/18367	0.000162767164524152	0.00544293398168764	COL1A2/SORBS2/SYNPO2/COL11A1/FLRT3/COL8A2/GAS6/SLC9A3R2/FSCN1/COL14A1/ATP1B1/IRS1/SERINC1/PIK3R1/SOCS2/PAG1/STX2/ABI2/STON1/EPS8/KLF4/AP2B1/SYNE1/DAB2/FRS2/AMFR/STAT3/AKAP13	28
GO:0001968	fibronectin binding	7/822	28/18367	0.000181789229573354	0.00584522292012786	IGFBP3/IGFBP5/THBS1/CTSK/CCDC80/ITGB1/FBLN1	7
GO:0033218	amide binding	34/822	400/18367	0.000270591709898735	0.00820486931286268	VIPR2/CD36/CRYAB/EDNRB/APOE/PRLR/CMKLR1/ECE1/RAMP1/FKBP7/HLA-B/ANPEP/LAPTM4B/HLA-A/FKBP10/HLA-C/HSPG2/LRP1/PPIC/PLTP/SLC40A1/CLU/PIK3R1/SEC61A1/PRNP/APBB2/AP2B1/HLA-F/NPEPPS/CLSTN1/PGRMC1/GSTM3/PANK3/LNPEP	34
GO:0042277	peptide binding	29/822	321/18367	0.000274804235359037	0.00820486931286268	VIPR2/CD36/CRYAB/EDNRB/APOE/PRLR/CMKLR1/ECE1/RAMP1/HLA-B/ANPEP/HLA-A/HLA-C/HSPG2/LRP1/PPIC/SLC40A1/CLU/PIK3R1/SEC61A1/PRNP/APBB2/AP2B1/HLA-F/NPEPPS/CLSTN1/PGRMC1/GSTM3/LNPEP	29
GO:0048185	activin binding	5/822	15/18367	0.000365920352399544	0.0101969804868673	FST/ACVR2A/TGFBR3/TGFBR2/ENG	5
GO:0051371	muscle alpha-actinin binding	5/822	15/18367	0.000365920352399544	0.0101969804868673	SYNPO2/PALLD/PDLIM7/PDLIM5/PKD2	5
GO:0004713	protein tyrosine kinase activity	16/822	136/18367	0.00038637645747813	0.0104197005952167	PDGFRA/DDR2/PDGFRB/EPHA3/FGFR1/PEAK1/NRP2/AXL/ABL1/HIPK3/DSTYK/IGF2R/FER/HIPK1/CRIM1/JAK1	16
GO:0008307	structural constituent of muscle	8/822	42/18367	0.000474007652051852	0.0123834499098546	MYL9/SORBS2/TPM2/NEXN/NEBL/TPM4/PLEC/TPM1	8
GO:0060090	molecular adaptor activity	31/822	369/18367	0.000603147933971691	0.0148967097158688	COL1A2/SORBS2/SYNPO2/COL11A1/FLRT3/COL8A2/GAS6/SLC9A3R2/FSCN1/COL14A1/ATP1B1/IRS1/SERINC1/PIK3R1/SOCS2/PAG1/STX2/ABI2/STON1/EPS8/KLF4/AP2B1/SYNE1/DAB2/MAGI3/FRS2/AMFR/STAT3/RB1CC1/AKAP13/ITSN1	31
GO:0038024	cargo receptor activity	11/822	77/18367	0.000605847045860694	0.0148967097158688	ENPP1/ENPP2/VTN/SCARF2/CD36/LRP1/LRP6/SCARB2/LGALS3BP/DAB2/VLDLR	11
GO:0061134	peptidase regulator activity	22/822	230/18367	0.000678771035770038	0.0162129310258215	COL6A3/WFDC1/PCOLCE/PROS1/GAS6/SERPINE2/GPC3/TIMP1/BIN1/SERPING1/PCOLCE2/SERPINF1/TIMP3/TFPI/A2M/SERPINH1/PRNP/BST2/TIMP2/FBLN1/SERPINB9/CRIM1	22
GO:0030414	peptidase inhibitor activity	19/822	187/18367	0.000745646623867238	0.0173155715986947	COL6A3/WFDC1/PROS1/GAS6/SERPINE2/GPC3/TIMP1/BIN1/SERPING1/SERPINF1/TIMP3/TFPI/A2M/SERPINH1/PRNP/BST2/TIMP2/SERPINB9/CRIM1	19
GO:0005044	scavenger receptor activity	8/822	47/18367	0.00103690916581872	0.0234285422330933	ENPP1/ENPP2/VTN/SCARF2/CD36/LRP1/SCARB2/LGALS3BP	8
GO:0098631	cell adhesion mediator activity	9/822	59/18367	0.00115996095416224	0.0253861827061443	EMILIN1/STXBP6/ITGA1/NEXN/PALLD/CNN3/PDLIM5/ITGB1/NPTN	9
GO:0015026	coreceptor activity	8/822	48/18367	0.0011962770738042	0.0253861827061443	RAMP1/ACVR2A/TGFBR3/PTK7/LRP1/LRP6/ENG/ITGB1	8
GO:0004866	endopeptidase inhibitor activity	18/822	180/18367	0.00121969344522704	0.0253861827061443	COL6A3/WFDC1/PROS1/GAS6/SERPINE2/TIMP1/BIN1/SERPING1/SERPINF1/TIMP3/TFPI/A2M/SERPINH1/PRNP/BST2/TIMP2/SERPINB9/CRIM1	18
GO:0043236	laminin binding	6/822	28/18367	0.00127538238475845	0.0253861827061443	NID1/SLIT2/ECM1/THBS1/LGALS1/ITGB1	6
GO:0070325	lipoprotein particle receptor binding	6/822	28/18367	0.00127538238475845	0.0253861827061443	APOE/HSPG2/LRP1/CLU/HSP90B1/CLTC	6
GO:0042562	hormone binding	11/822	86/18367	0.00154183320066723	0.0291293031624038	VIPR2/EDNRB/PRLR/CMKLR1/THRA/ECE1/RAMP1/SLC40A1/NR3C1/PIK3R1/TSPO	11
GO:0005520	insulin-like growth factor binding	6/822	29/18367	0.00154797369562564	0.0291293031624038	IGFBP3/IGFBP2/IGFBP5/HTRA1/IGF2R/CRIM1	6
GO:0035014	phosphatidylinositol 3-kinase regulator activity	5/822	20/18367	0.00156796488314375	0.0291293031624038	PIK3R1/SOCS2/CISH/SOCS3/KLF4	5
GO:0017046	peptide hormone binding	8/822	52/18367	0.00203876637263285	0.0370523627721971	VIPR2/EDNRB/PRLR/CMKLR1/ECE1/RAMP1/SLC40A1/PIK3R1	8
GO:0031005	filamin binding	4/822	14/18367	0.00278128238544827	0.0488683121966553	SYNPO2/DPYSL3/FBLIM1/NEBL	4
GO:0061135	endopeptidase regulator activity	18/822	194/18367	0.00280583610698499	0.0488683121966553	COL6A3/WFDC1/PROS1/GAS6/SERPINE2/TIMP1/BIN1/SERPING1/SERPINF1/TIMP3/TFPI/A2M/SERPINH1/PRNP/BST2/TIMP2/SERPINB9/CRIM1	18
GO:0005158	insulin receptor binding	5/822	23/18367	0.00304464703344615	0.0509064983992196	ENPP1/IGF2/IRS1/PIK3R1/CCDC88A	5
GO:0050750	low-density lipoprotein particle receptor binding	5/822	23/18367	0.00304464703344615	0.0509064983992196	APOE/HSPG2/CLU/HSP90B1/CLTC	5
GO:0048156	tau protein binding	7/822	45/18367	0.0036001734228746	0.0573400092535416	APOE/BIN1/HSPA2/CLU/ROCK2/TAOK1/PRKAA1	7
GO:0005041	low-density lipoprotein particle receptor activity	4/822	15/18367	0.00365959585201144	0.0573400092535416	CD36/LRP1/LRP6/VLDLR	4
GO:0005161	platelet-derived growth factor receptor binding	4/822	15/18367	0.00365959585201144	0.0573400092535416	PDGFRA/PDGFRB/IL1R1/PTEN	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	13/822	124/18367	0.00370378050202302	0.0573400092535416	PDGFRA/DDR2/PDGFRB/EPHA3/FGFR1/NRP2/AXL/ABL1/DSTYK/IGF2R/FER/CRIM1/JAK1	13
GO:0001540	amyloid-beta binding	10/822	84/18367	0.00421792258255566	0.064112423254846	CD36/CRYAB/APOE/HSPG2/LRP1/CLU/PRNP/APBB2/CLSTN1/PGRMC1	10
GO:0005159	insulin-like growth factor receptor binding	4/822	16/18367	0.00470855157364387	0.0656058185927712	IGF2/IRS1/PIK3R1/SOCS2	4
GO:0005521	lamin binding	4/822	16/18367	0.00470855157364387	0.0656058185927712	PRNP/PLCB1/SYNE1/BNIP3L	4
GO:0005523	tropomyosin binding	4/822	16/18367	0.00470855157364387	0.0656058185927712	LMOD1/CALD1/NEBL/S100A6	4
GO:0008191	metalloendopeptidase inhibitor activity	4/822	16/18367	0.00470855157364387	0.0656058185927712	TIMP1/TIMP3/BST2/TIMP2	4
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	4/822	16/18367	0.00470855157364387	0.0656058185927712	PIK3R1/SOCS2/CISH/SOCS3	4
GO:0042805	actinin binding	6/822	36/18367	0.00486650458284594	0.0666950464140853	SYNPO2/PROM1/PALLD/PDLIM7/PDLIM5/PKD2	6
GO:0070888	E-box binding	7/822	48/18367	0.00520367767250888	0.0701657182938294	TCF21/HAND2/SNAI2/TCF4/TWIST1/TCF12/CLOCK	7
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	4/822	17/18367	0.00594202638188363	0.0764236008500725	PTPRD/PTPRK/PTPRG/PTPRA	4
GO:0019198	transmembrane receptor protein phosphatase activity	4/822	17/18367	0.00594202638188363	0.0764236008500725	PTPRD/PTPRK/PTPRG/PTPRA	4
GO:0070064	proline-rich region binding	4/822	17/18367	0.00594202638188363	0.0764236008500725	YAP1/ABI2/ABL1/ITSN1	4
GO:0051393	alpha-actinin binding	5/822	27/18367	0.00630153193668406	0.0791987898816047	SYNPO2/PALLD/PDLIM7/PDLIM5/PKD2	5
GO:0043178	alcohol binding	10/822	89/18367	0.00636677641486504	0.0791987898816047	APOD/RBP1/CRABP1/PROM1/CD81/TSPO/SCARB2/OSBPL1A/RBP7/NPC2	10
GO:0005543	phospholipid binding	33/822	466/18367	0.0064610429395395	0.0791987898816047	F3/PLA2G2A/THY1/STXBP6/MAP1B/MYO1B/GAS6/THBS1/LPAR1/MFGE8/APOE/BIN1/MYO10/SPTBN1/LAPTM4B/MYO1E/AXL/PLTP/SH3PXD2A/PLCB1/PXK/SESTD1/SCARB2/SBF2/ASAP1/TPCN1/JAG1/OSBPL1A/SNX29/CCDC88A/GSN/STAM2/ESYT2	33
GO:0015485	cholesterol binding	7/822	50/18367	0.00653674222707024	0.0791987898816047	APOD/PROM1/CD81/TSPO/SCARB2/OSBPL1A/NPC2	7
GO:0030228	lipoprotein particle receptor activity	4/822	18/18367	0.00737304921468633	0.0880552734782539	CD36/LRP1/LRP6/VLDLR	4
GO:0042169	SH2 domain binding	6/822	40/18367	0.00824629489368196	0.0969054683781978	IRS1/ARHGAP5/PAG1/DLC1/ABL1/CCDC88A	6
GO:0004690	cyclic nucleotide-dependent protein kinase activity	3/822	10/18367	0.0084618411382876	0.0969054683781978	PRKG1/PRKAA1/AKAP13	3
GO:0017002	activin-activated receptor activity	3/822	10/18367	0.0084618411382876	0.0969054683781978	ACVR2A/TGFBR2/BMPR2	3
GO:0019207	kinase regulator activity	19/822	233/18367	0.00874281827122155	0.0987702172262326	CCND2/GAS6/CAMK2N1/IGF2/CCNG2/PIK3R1/SOCS2/CISH/LRP6/SOCS3/SPRED1/KLF4/BMPR2/PRKAR1A/PKIG/TAOK1/WNK1/KIDINS220/HSPB1	19
GO:0035591	signaling adaptor activity	9/822	81/18367	0.0100974115067344	0.112552480261733	IRS1/PIK3R1/SOCS2/PAG1/ABI2/EPS8/FRS2/STAT3/AKAP13	9
GO:0019211	phosphatase activator activity	4/822	20/18367	0.0108751618651122	0.116338461720339	IGFBP3/BMPR2/PPP2R5E/FRS2	4
GO:0030506	ankyrin binding	4/822	20/18367	0.0108751618651122	0.116338461720339	SPTBN1/NRCAM/PLEC/SLC8A1	4
GO:0005080	protein kinase C binding	7/822	55/18367	0.0109638702215735	0.116338461720339	MARCKS/FLNA/IRS1/PDLIM5/ABL1/CCDC88A/HSPB1	7
GO:0008022	protein C-terminus binding	16/822	189/18367	0.0109937063108932	0.116338461720339	FBLN5/ECM1/TCF4/SLC9A3R2/ATP1B1/DST/HSPG2/MPDZ/YAP1/SDC1/ABL1/FBLN1/DAB2/PRKAA1/MYO1C/ATXN1	16
GO:0022889	serine transmembrane transporter activity	3/822	11/18367	0.0112521699968178	0.116736009955468	SERINC3/SLC38A2/SERINC5	3
GO:0071813	lipoprotein particle binding	5/822	31/18367	0.0114501827946751	0.116736009955468	CD36/THBS1/APOE/PLTP/VLDLR	5
GO:0071814	protein-lipid complex binding	5/822	31/18367	0.0114501827946751	0.116736009955468	CD36/THBS1/APOE/PLTP/VLDLR	5
GO:0004252	serine-type endopeptidase activity	15/822	174/18367	0.0115963951037445	0.116802244659403	F3/MMP2/FAP/C1R/C1S/CFD/CTSK/PLAU/C2/HTRA1/DPP4/PCSK6/BMP1/PREPL/MBTPS1	15
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	31/822	450/18367	0.0117756792141229	0.117196045511985	PLAGL1/TCF21/NDN/HAND2/CREB3L1/HOXA13/PITX1/GATA4/TCF4/MAF/NFIA/OSR2/MEIS2/GLIS2/NFIB/CEBPD/EPAS1/NR3C1/NFAT5/MLXIP/KLF4/NFIC/FOSL2/LITAF/FOXO3/STAT3/TCF12/KLF6/BACH1/CREBRF/CLOCK	31
GO:0008236	serine-type peptidase activity	16/822	191/18367	0.0120742533720297	0.118753833164904	F3/MMP2/FAP/C1R/C1S/CFD/CTSK/PLAU/C2/HTRA1/DPP4/PCSK6/BMP1/PREPL/MBTPS1/CTSA	16
GO:0004867	serine-type endopeptidase inhibitor activity	10/822	98/18367	0.0122745177979197	0.119319731151871	COL6A3/WFDC1/SERPINE2/SERPING1/SERPINF1/TFPI/A2M/SERPINH1/SERPINB9/CRIM1	10
GO:0001216	DNA-binding transcription activator activity	31/822	456/18367	0.0139963751775205	0.13449390400468	PLAGL1/TCF21/NDN/HAND2/CREB3L1/HOXA13/PITX1/GATA4/TCF4/MAF/NFIA/OSR2/MEIS2/GLIS2/NFIB/CEBPD/EPAS1/NR3C1/NFAT5/MLXIP/KLF4/NFIC/FOSL2/LITAF/FOXO3/STAT3/TCF12/KLF6/BACH1/CREBRF/CLOCK	31
GO:0017171	serine hydrolase activity	16/822	195/18367	0.0144842989055247	0.136300013250151	F3/MMP2/FAP/C1R/C1S/CFD/CTSK/PLAU/C2/HTRA1/DPP4/PCSK6/BMP1/PREPL/MBTPS1/CTSA	16
GO:0008429	phosphatidylethanolamine binding	3/822	12/18367	0.0145104081091667	0.136300013250151	MFGE8/PLTP/ESYT2	3
GO:0019956	chemokine binding	5/822	33/18367	0.0148652653708563	0.13734218437179	PDPN/ACKR1/PLP2/A2M/ITGB1	5
GO:0004674	protein serine/threonine kinase activity	27/822	386/18367	0.0149499267677427	0.13734218437179	LTBP4/PRKG1/MYLK/PRKCA/ACVR2A/CASK/TGFBR3/CDK18/FAM20C/CAMK2D/CDC42BPA/ROCK2/TGFBR2/ENG/MAP3K8/BMPR2/MAP4K5/TAOK1/HIPK3/WNK1/DAPK1/PRKAA1/MAP4K4/HIPK1/NEK7/ATM/AKAP13	27
GO:0120020	cholesterol transfer activity	4/822	22/18367	0.0152996206532198	0.139026987674911	APOE/PLTP/TSPO/NPC2	4
GO:0044325	transmembrane transporter binding	12/822	133/18367	0.0162567873156122	0.146136281675826	FHL1/FXYD1/FLNA/CAMK2D/PKD1/PKD2/TSPO/PRNP/SLC5A3/NPTN/SLC8A1/ACTN4	12
GO:0030291	protein serine/threonine kinase inhibitor activity	5/822	34/18367	0.0168033273689702	0.146408397900758	SPRED1/PRKAR1A/PKIG/WNK1/HSPB1	5
GO:0043548	phosphatidylinositol 3-kinase binding	5/822	34/18367	0.0168033273689702	0.146408397900758	PDGFRB/IRS1/AXL/PIK3R1/GSN	5
GO:0051219	phosphoprotein binding	9/822	88/18367	0.0168124476058286	0.146408397900758	LRP11/IRS1/PKD2/PIK3R1/SOCS3/SH3BP2/ABL1/IGF2R/RTF1	9
GO:0032934	sterol binding	7/822	60/18367	0.0172413976016838	0.147909523141528	APOD/PROM1/CD81/TSPO/SCARB2/OSBPL1A/NPC2	7
GO:0019210	kinase inhibitor activity	8/822	74/18367	0.017338676157739	0.147909523141528	CAMK2N1/LRP6/SOCS3/SPRED1/PRKAR1A/PKIG/WNK1/HSPB1	8
GO:0120015	sterol transfer activity	4/822	23/18367	0.017879615099488	0.150983416395676	APOE/PLTP/TSPO/NPC2	4
GO:0008195	phosphatidate phosphatase activity	3/822	13/18367	0.0182458347637993	0.151024929332042	PLPP1/PLPP3/LPIN1	3
GO:0031994	insulin-like growth factor I binding	3/822	13/18367	0.0182458347637993	0.151024929332042	IGFBP3/IGFBP2/IGFBP5	3
GO:0001618	virus receptor activity	8/822	76/18367	0.0200814681101982	0.164589287648291	EFNB2/CLDN1/ANPEP/CD81/AXL/DPP4/ITGB1/SCARB2	8
GO:0015248	sterol transporter activity	5/822	36/18367	0.0211656887272397	0.171679507251481	APOE/PLTP/TSPO/OSBPL1A/NPC2	5
GO:0098632	cell-cell adhesion mediator activity	6/822	49/18367	0.0214408723524178	0.171679507251481	STXBP6/NEXN/PALLD/CNN3/PDLIM5/NPTN	6
GO:0140272	exogenous protein binding	8/822	77/18367	0.0215626175375665	0.171679507251481	EFNB2/CLDN1/ANPEP/CD81/AXL/DPP4/ITGB1/SCARB2	8
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	3/822	14/18367	0.022463439957895	0.177164488724531	IRS1/PIK3R1/FRS2	3
GO:0005109	frizzled binding	5/822	37/18367	0.0235989294729788	0.1809520269584	CTHRC1/WNT2/RSPO3/BAMBI/LRP6	5
GO:0005104	fibroblast growth factor receptor binding	4/822	25/18367	0.0238094772313684	0.1809520269584	FGF7/FLRT3/FRS2/NPTN	4
GO:0005160	transforming growth factor beta receptor binding	4/822	25/18367	0.0238094772313684	0.1809520269584	BAMBI/TGFBR3/TGFBR2/ENG	4
GO:0008266	poly(U) RNA binding	4/822	25/18367	0.0238094772313684	0.1809520269584	PABPC4L/RBMS3/RBMS1/ATXN1	4
GO:0070851	growth factor receptor binding	12/822	141/18367	0.0245305065330178	0.184752283437864	PDGFRA/FGF7/ECM1/PDGFRB/FLRT3/IL1R1/IL6ST/PTEN/FRS2/NPTN/FER/CCDC88A	12
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	5/822	38/18367	0.0262055088042039	0.192173731230828	FKBP7/FKBP10/PPIC/FKBP9/FKBP14	5
GO:0005501	retinoid binding	5/822	38/18367	0.0262055088042039	0.192173731230828	PTGDS/RBP1/CRABP1/IGF2R/RBP7	5
GO:0019840	isoprenoid binding	5/822	38/18367	0.0262055088042039	0.192173731230828	PTGDS/RBP1/CRABP1/IGF2R/RBP7	5
GO:0004896	cytokine receptor activity	9/822	97/18367	0.0296217161848796	0.215336997657038	F3/OSMR/IL1R1/PRLR/CMKLR1/IL6ST/IFNGR2/LIFR/IFNAR1	9
GO:0008083	growth factor activity	13/822	162/18367	0.0302459332218978	0.217979311840574	HGF/BMP5/FGF7/CSF1/KITLG/GDF6/BMP4/TIMP1/IGF2/MDK/CLEC11A/BMP1/JAG1	13
GO:0004175	endopeptidase activity	28/822	430/18367	0.0307497893182755	0.21820404490631	F3/MMP2/MMP23B/ADAMTS5/FAP/C1R/C1S/ADAMTS2/ADAMTS15/CFD/CTSK/ADAM12/ADAMTS1/ECE1/PLAU/C2/HTRA1/DPP4/CTSO/PCSK6/BMP1/CAPN2/PREPL/TMEM59/USP11/MBTPS1/USP47/USP9X	28
GO:0045499	chemorepellent activity	4/822	27/18367	0.0307991355250533	0.21820404490631	FLRT3/SEMA3B/DPP4/SEMA6D	4
GO:0019841	retinol binding	3/822	16/18367	0.0323465200791479	0.227241099043426	RBP1/CRABP1/RBP7	3
GO:0008187	poly-pyrimidine tract binding	4/822	28/18367	0.0346999625886248	0.24050956148666	PABPC4L/RBMS3/RBMS1/ATXN1	4
GO:0016859	cis-trans isomerase activity	5/822	41/18367	0.0350978172017062	0.24050956148666	FKBP7/FKBP10/PPIC/FKBP9/FKBP14	5
GO:0005496	steroid binding	9/822	100/18367	0.035098285288723	0.24050956148666	APOD/PROM1/CD81/NR3C1/TSPO/SCARB2/OSBPL1A/PGRMC1/NPC2	9
GO:0005126	cytokine receptor binding	19/822	271/18367	0.0360849754517056	0.242598456281803	CXCL14/ECM1/CSF1/KITLG/OSMR/BAMBI/PRLR/IL6ST/TGFBR3/PIK3R1/SOCS2/TGFBR2/ENG/SPRED1/LIFR/FRS2/STAT3/CCDC88A/JAK1	19
GO:0030246	carbohydrate binding	19/822	271/18367	0.0360849754517056	0.242598456281803	ENPP1/ENPP2/VTN/CD248/VCAN/MRC2/P4HA2/PLOD2/LGALS1/PKD1/CLEC11A/EGLN3/ENG/H6PD/PLA2R1/GALNT1/IGF2R/UAP1/CANX	19
GO:0008013	beta-catenin binding	8/822	85/18367	0.0362736926258676	0.242598456281803	TCF4/SLC9A3R2/GJA1/PTPRK/KLF4/TBL1XR1/VCL/FOXO3	8
GO:0004860	protein kinase inhibitor activity	7/822	70/18367	0.0366369070567872	0.243082970630747	CAMK2N1/SOCS3/SPRED1/PRKAR1A/PKIG/WNK1/HSPB1	7
GO:0016722	oxidoreductase activity, acting on metal ions	3/822	17/18367	0.0380046258714189	0.244398978680817	CYBRD1/STEAP4/FRRS1	3
GO:0030169	low-density lipoprotein particle binding	3/822	17/18367	0.0380046258714189	0.244398978680817	CD36/THBS1/PLTP	3
GO:0034185	apolipoprotein binding	3/822	17/18367	0.0380046258714189	0.244398978680817	LRP1/VLDLR/CANX	3
GO:0043395	heparan sulfate proteoglycan binding	3/822	17/18367	0.0380046258714189	0.244398978680817	FST/APOE/LRP1	3
GO:0045309	protein phosphorylated amino acid binding	6/822	56/18367	0.0383856340841153	0.244964809880308	IRS1/PIK3R1/SOCS3/SH3BP2/ABL1/RTF1	6
GO:0070717	poly-purine tract binding	4/822	29/18367	0.0388740155848915	0.246202098704313	PABPC4L/RBMS3/RBMS1/ATXN1	4
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21/822	310/18367	0.0393210957491797	0.247161173280558	PLAGL1/TCF21/AEBP1/NR2F1/CREB3L1/MSC/TBX2/SNAI2/ZEB2/SMAD5/NR3C1/ZBTB4/ZNF281/SKIL/FOXO3/SKI/SP3/IFI16/BACH1/ZNF148/ZFHX3	21
GO:0005200	structural constituent of cytoskeleton	9/822	103/18367	0.0412332970037328	0.257246539515826	SORBS2/DES/PPL/VIM/SPTBN1/SORBS3/PLEC/TPM1/MSN	9
GO:0001217	DNA-binding transcription repressor activity	21/822	313/18367	0.0428509747466652	0.265358628801571	PLAGL1/TCF21/AEBP1/NR2F1/CREB3L1/MSC/TBX2/SNAI2/ZEB2/SMAD5/NR3C1/ZBTB4/ZNF281/SKIL/FOXO3/SKI/SP3/IFI16/BACH1/ZNF148/ZFHX3	21
GO:0098641	cadherin binding involved in cell-cell adhesion	3/822	18/18367	0.0441309412027654	0.271275491511117	STXBP6/CNN3/PDLIM5	3
GO:0001784	phosphotyrosine residue binding	5/822	44/18367	0.0456496668237261	0.278562930398796	IRS1/PIK3R1/SOCS3/SH3BP2/ABL1	5
GO:0003725	double-stranded RNA binding	7/822	74/18367	0.0473129982402662	0.286620771948279	VIM/MTDH/AGO3/SIDT2/MSN/CLTC/ZFR	7
GO:0000146	microfilament motor activity	4/822	31/18367	0.0480437681630361	0.288953886217973	MYO1B/MYO10/MYO1E/MYO1C	4
GO:1902936	phosphatidylinositol bisphosphate binding	9/822	107/18367	0.0504837170655128	0.29854333165178	STXBP6/MYO1B/LAPTM4B/SH3PXD2A/PLCB1/SESTD1/ASAP1/TPCN1/GSN	9
GO:0016918	retinal binding	3/822	19/18367	0.0507154197153992	0.29854333165178	RBP1/CRABP1/RBP7	3
GO:0035615	clathrin adaptor activity	3/822	19/18367	0.0507154197153992	0.29854333165178	STON1/AP2B1/DAB2	3
GO:0001786	phosphatidylserine binding	6/822	60/18367	0.0510666225193834	0.29854333165178	GAS6/THBS1/MFGE8/AXL/SCARB2/ASAP1	6
GO:0050699	WW domain binding	4/822	32/18367	0.0530382086741536	0.307916267024947	TCEAL3/ENAH/LITAF/NDFIP1	4
GO:0031418	L-ascorbic acid binding	3/822	20/18367	0.057746053453685	0.330655484159457	P4HA2/PLOD2/EGLN3	3
GO:0140312	cargo adaptor activity	3/822	20/18367	0.057746053453685	0.330655484159457	STON1/AP2B1/DAB2	3
GO:0004222	metalloendopeptidase activity	9/822	111/18367	0.0610036911715708	0.346932556594784	MMP2/MMP23B/ADAMTS5/ADAMTS2/ADAMTS15/ADAM12/ADAMTS1/ECE1/BMP1	9
GO:0035091	phosphatidylinositol binding	18/822	271/18367	0.0621243000260966	0.350918343390654	THY1/STXBP6/MYO1B/MYO10/LAPTM4B/MYO1E/SH3PXD2A/PLCB1/PXK/SESTD1/SBF2/ASAP1/TPCN1/SNX29/CCDC88A/GSN/STAM2/ESYT2	18
GO:0008376	acetylgalactosaminyltransferase activity	4/822	34/18367	0.063836790881797	0.358171524679076	CSGALNACT1/CSGALNACT2/GALNT1/CHPF2	4
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	3/822	21/18367	0.0652091535769069	0.358650344672988	LPGAT1/AGPAT2/LPCAT2	3
GO:0005385	zinc ion transmembrane transporter activity	3/822	21/18367	0.0652091535769069	0.358650344672988	SLC39A13/SLC39A6/SLC39A4	3
GO:1990381	ubiquitin-specific protease binding	3/822	21/18367	0.0652091535769069	0.358650344672988	PTEN/AMFR/CLTC	3
GO:0017124	SH3 domain binding	10/822	130/18367	0.0667278691930347	0.364604566309653	DPYSL3/PLSCR4/GJA1/ADAM12/ENAH/ZNF106/ABI2/SH3BP2/ABL1/SOS1	10
GO:0015298	solute:cation antiporter activity	4/822	35/18367	0.0696348396211734	0.366022351917854	CLCN5/SLC9A9/SLC8A1/TMCO3	4
GO:0004955	prostaglandin receptor activity	2/822	10/18367	0.0709277763285794	0.366022351917854	PTGFR/PTGER2	2
GO:0005522	profilin binding	2/822	10/18367	0.0709277763285794	0.366022351917854	ENAH/RHOQ	2
GO:0005528	FK506 binding	2/822	10/18367	0.0709277763285794	0.366022351917854	FKBP7/FKBP10	2
GO:0008172	S-methyltransferase activity	2/822	10/18367	0.0709277763285794	0.366022351917854	INMT/KMT2A	2
GO:0008190	eukaryotic initiation factor 4E binding	2/822	10/18367	0.0709277763285794	0.366022351917854	EIF4EBP1/EIF4EBP2	2
GO:0008239	dipeptidyl-peptidase activity	2/822	10/18367	0.0709277763285794	0.366022351917854	FAP/DPP4	2
GO:0034713	type I transforming growth factor beta receptor binding	2/822	10/18367	0.0709277763285794	0.366022351917854	TGFBR2/ENG	2
GO:0035374	chondroitin sulfate binding	2/822	10/18367	0.0709277763285794	0.366022351917854	DPYSL3/MDK	2
GO:0050321	tau-protein kinase activity	3/822	22/18367	0.0730896061438049	0.3748644830443	ROCK2/TAOK1/PRKAA1	3
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	7/822	82/18367	0.0741097478649208	0.377778958628499	STXBP6/MYO1B/SH3PXD2A/PLCB1/SESTD1/ASAP1/GSN	7
GO:0019887	protein kinase regulator activity	14/822	204/18367	0.0747407103996697	0.378686266024993	CCND2/GAS6/CAMK2N1/IGF2/CCNG2/SOCS3/SPRED1/BMPR2/PRKAR1A/PKIG/TAOK1/WNK1/KIDINS220/HSPB1	14
GO:0003712	transcription coregulator activity	29/822	489/18367	0.0755215809718328	0.378920671806689	RUNX1T1/LDB2/JAZF1/PIAS2/BASP1/KAT6B/NCOR2/MTDH/LMCD1/YAP1/NUPR1/HCFC2/RSF1/MED13L/DDX17/LPIN1/ABL1/N4BP2L2/MAML2/TBL1XR1/PHF10/ARID5B/ZMYND11/ZMIZ1/MIER1/NUCKS1/ACTN4/MED13/NCOA1	29
GO:0042605	peptide antigen binding	4/822	36/18367	0.0756934834829151	0.378920671806689	HLA-B/HLA-A/HLA-C/HLA-F	4
GO:0008143	poly(A) binding	3/822	23/18367	0.0813711048004525	0.39176381141747	PABPC4L/RBMS3/RBMS1	3
GO:0015299	solute:proton antiporter activity	3/822	23/18367	0.0813711048004525	0.39176381141747	CLCN5/SLC9A9/TMCO3	3
GO:0017134	fibroblast growth factor binding	3/822	23/18367	0.0813711048004525	0.39176381141747	THBS1/FGFR1/TGFBR3	3
GO:0042171	lysophosphatidic acid acyltransferase activity	3/822	23/18367	0.0813711048004525	0.39176381141747	LPGAT1/AGPAT2/LPCAT2	3
GO:0071617	lysophospholipid acyltransferase activity	3/822	23/18367	0.0813711048004525	0.39176381141747	LPGAT1/AGPAT2/LPCAT2	3
GO:0030165	PDZ domain binding	7/822	84/18367	0.08196459418123	0.39176381141747	SDC2/GJA1/ACVR2A/TGFBR3/PTEN/KIDINS220/CRIM1	7
GO:0042056	chemoattractant activity	4/822	37/18367	0.082007974878059	0.39176381141747	HGF/FGF7/BMP4/GPNMB	4
GO:0046915	transition metal ion transmembrane transporter activity	4/822	37/18367	0.082007974878059	0.39176381141747	SLC39A13/SLC39A6/SLC40A1/SLC39A4	4
GO:0002162	dystroglycan binding	2/822	11/18367	0.084189022180082	0.395404621025554	PLEC/VCL	2
GO:0004954	prostanoid receptor activity	2/822	11/18367	0.084189022180082	0.395404621025554	PTGFR/PTGER2	2
GO:0008603	cAMP-dependent protein kinase regulator activity	2/822	11/18367	0.084189022180082	0.395404621025554	PRKAR1A/PKIG	2
GO:0008237	metallopeptidase activity	13/822	190/18367	0.085185647917884	0.397850288599727	MMP2/MMP23B/ADAMTS5/CPXM1/ADAMTS2/ADAMTS15/ADAM12/ADAMTS1/ECE1/ANPEP/BMP1/NPEPPS/LNPEP	13
GO:0008238	exopeptidase activity	8/822	103/18367	0.0905087220651575	0.420362731369287	FAP/CPXM1/SCRN1/ANPEP/DPP4/NPEPPS/LNPEP/CTSA	8
GO:0005165	neurotrophin receptor binding	2/822	12/18367	0.0981247449942651	0.433613945411137	PIK3R1/FRS2	2
GO:0005527	macrolide binding	2/822	12/18367	0.0981247449942651	0.433613945411137	FKBP7/FKBP10	2
GO:0017154	semaphorin receptor activity	2/822	12/18367	0.0981247449942651	0.433613945411137	NRP2/PLXNB2	2
GO:0031543	peptidyl-proline dioxygenase activity	2/822	12/18367	0.0981247449942651	0.433613945411137	P4HA2/EGLN3	2
GO:0035004	phosphatidylinositol 3-kinase activity	2/822	12/18367	0.0981247449942651	0.433613945411137	ATM/IPMK	2
GO:0035256	G protein-coupled glutamate receptor binding	2/822	12/18367	0.0981247449942651	0.433613945411137	SLC9A3R2/PRNP	2
GO:0043422	protein kinase B binding	2/822	12/18367	0.0981247449942651	0.433613945411137	PDE3B/CCDC88A	2
GO:0070410	co-SMAD binding	2/822	12/18367	0.0981247449942651	0.433613945411137	GATA4/USP9X	2
GO:1990782	protein tyrosine kinase binding	8/822	105/18367	0.0984509101300157	0.433613945411137	GAS6/ANGPT1/IRS1/PTEN/PIK3R1/ITGB1/BMPR2/FRS2	8
GO:0030247	polysaccharide binding	3/822	25/18367	0.0990673009252718	0.433613945411137	ENPP1/ENPP2/VTN	3
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/822	25/18367	0.0990673009252718	0.433613945411137	RBMS3/ZFP36L2/ZFP36L1	3
GO:0008017	microtubule binding	17/822	271/18367	0.101762858297367	0.440808819478585	MAP1B/CRYAB/DST/CNN3/PRNP/NDRG1/NIN/CEP44/MAP9/SBDS/EML4/DPYSL2/MAP4K4/CCDC88A/MTUS1/TERF1/MACF1	17
GO:0019902	phosphatase binding	13/822	196/18367	0.102120461097555	0.440808819478585	ITGA1/SLC9A3R2/MFHAS1/PIK3R1/EIF4EBP1/SPRED1/SBF2/HSP90B1/WNK1/STAT3/FER/STRN3/JAK1	13
GO:0004177	aminopeptidase activity	4/822	40/18367	0.102430409408721	0.440808819478585	ANPEP/DPP4/NPEPPS/LNPEP	4
GO:0030276	clathrin binding	6/822	72/18367	0.102820238993211	0.440808819478585	BIN1/LRP1/STON1/AP2B1/DAB2/CLTC	6
GO:0019208	phosphatase regulator activity	8/822	107/18367	0.106773542014147	0.453110056466125	IGFBP3/PHACTR2/ZEB2/PPP1R14A/SBF2/BMPR2/PPP2R5E/FRS2	8
GO:0051087	chaperone binding	8/822	107/18367	0.106773542014147	0.453110056466125	PDPN/BIN1/HLA-B/HSPA2/CLU/PRNP/SCARB2/AMFR	8
GO:0030371	translation repressor activity	3/822	26/18367	0.108445227882564	0.455578947285543	EIF4EBP1/PURA/EIF4EBP2	3
GO:0042974	retinoic acid receptor binding	3/822	26/18367	0.108445227882564	0.455578947285543	NCOR2/ACTN4/NCOA1	3
GO:0008035	high-density lipoprotein particle binding	2/822	13/18367	0.112648183217986	0.457154762962312	CD36/PLTP	2
GO:0032036	myosin heavy chain binding	2/822	13/18367	0.112648183217986	0.457154762962312	MYL9/AXL	2
GO:0034236	protein kinase A catalytic subunit binding	2/822	13/18367	0.112648183217986	0.457154762962312	PRKAR1A/PJA2	2
GO:0039706	co-receptor binding	2/822	13/18367	0.112648183217986	0.457154762962312	DKK3/BMP4	2
GO:0051011	microtubule minus-end binding	2/822	13/18367	0.112648183217986	0.457154762962312	NIN/MACF1	2
GO:0070700	BMP receptor binding	2/822	13/18367	0.112648183217986	0.457154762962312	BMP5/BMP4	2
GO:0072542	protein phosphatase activator activity	2/822	13/18367	0.112648183217986	0.457154762962312	IGFBP3/PPP2R5E	2
GO:0140297	DNA-binding transcription factor binding	23/822	394/18367	0.117642849444391	0.4703534626723	TCF21/PITX2/RUNX1T1/HAND2/GATA6/PITX1/GATA4/CXXC5/NCOR2/MTDH/TWIST1/YAP1/NOTCH2/KLF4/PURA/SKI/STAT3/TCF12/SP3/HSPB1/ACTN4/MED13/NCOA1	23
GO:0023026	MHC class II protein complex binding	3/822	27/18367	0.118150989427252	0.4703534626723	ATP1B1/CD81/B2M	3
GO:0043425	bHLH transcription factor binding	3/822	27/18367	0.118150989427252	0.4703534626723	TCF21/TWIST1/TCF12	3
GO:0070006	metalloaminopeptidase activity	3/822	27/18367	0.118150989427252	0.4703534626723	ANPEP/NPEPPS/LNPEP	3
GO:0031267	small GTPase binding	16/822	259/18367	0.120890039901507	0.478976650984168	CDC42EP5/FLNA/ROCK2/FMNL2/NDRG1/ABI2/EPS8/NCKAP1/EVI5/MYO1C/AKAP13/STRN3/GOLGA4/FARP1/DAAM1/CHML	16
GO:0072341	modified amino acid binding	7/822	93/18367	0.122931553508485	0.484767824212707	GAS6/THBS1/MFGE8/AXL/SCARB2/ASAP1/GSTM3	7
GO:0035259	glucocorticoid receptor binding	2/822	14/18367	0.127678973761335	0.498353647319228	NCOR2/STAT3	2
GO:0044548	S100 protein binding	2/822	14/18367	0.127678973761335	0.498353647319228	S100A6/AHNAK	2
GO:0046875	ephrin receptor binding	3/822	28/18367	0.128165112647888	0.498353647319228	CHN1/EFNB2/ABL1	3
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/822	45/18367	0.140989581447122	0.543942465916531	PEAK1/ABL1/FER/JAK1	4
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/822	15/18367	0.143142754188561	0.543942465916531	PDE3A/PDE3B	2
GO:0004953	icosanoid receptor activity	2/822	15/18367	0.143142754188561	0.543942465916531	PTGFR/PTGER2	2
GO:0042813	Wnt-activated receptor activity	2/822	15/18367	0.143142754188561	0.543942465916531	PKD1/LRP6	2
GO:0043138	3'-5' DNA helicase activity	2/822	15/18367	0.143142754188561	0.543942465916531	RECQL/NAV2	2
GO:0017147	Wnt-protein binding	3/822	30/18367	0.149039700020604	0.56124860007759	CTHRC1/APCDD1/LRP6	3
GO:0070566	adenylyltransferase activity	3/822	30/18367	0.149039700020604	0.56124860007759	PAPSS2/ABL1/PAPSS1	3
GO:0005319	lipid transporter activity	10/822	154/18367	0.153059175686836	0.571126235528248	APOD/ABCA8/CD36/PLSCR4/APOE/PLTP/TSPO/OSBPL1A/NPC2/ABCA5	10
GO:0035254	glutamate receptor binding	4/822	47/18367	0.157813389989787	0.571126235528248	SLC9A3R2/PTEN/PRNP/CANX	4
GO:0005092	GDP-dissociation inhibitor activity	2/822	16/18367	0.158970787632762	0.571126235528248	CCDC88A/CHML	2
GO:0005402	carbohydrate:cation symporter activity	2/822	16/18367	0.158970787632762	0.571126235528248	SLC2A10/SLC5A3	2
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/822	16/18367	0.158970787632762	0.571126235528248	VCAM1/LOXL1	2
GO:0035173	histone kinase activity	2/822	16/18367	0.158970787632762	0.571126235528248	PRKCA/PRKAA1	2
GO:0035497	cAMP response element binding	2/822	16/18367	0.158970787632762	0.571126235528248	CREB3L1/TCF12	2
GO:0036122	BMP binding	2/822	16/18367	0.158970787632762	0.571126235528248	ENG/BMPR2	2
GO:0042577	lipid phosphatase activity	2/822	16/18367	0.158970787632762	0.571126235528248	PLPP1/PLPP3	2
GO:0051020	GTPase binding	17/822	291/18367	0.159485787705352	0.571126235528248	CDC42EP5/FLNA/SPTBN1/ROCK2/FMNL2/NDRG1/ABI2/EPS8/NCKAP1/EVI5/MYO1C/AKAP13/STRN3/GOLGA4/FARP1/DAAM1/CHML	17
GO:0016411	acylglycerol O-acyltransferase activity	3/822	31/18367	0.159860692719629	0.571126235528248	LPGAT1/AGPAT2/LPCAT2	3
GO:0031210	phosphatidylcholine binding	3/822	31/18367	0.159860692719629	0.571126235528248	PLTP/SCARB2/ESYT2	3
GO:0120013	lipid transfer activity	4/822	48/18367	0.166491044254019	0.592283034027064	APOE/PLTP/TSPO/NPC2	4
GO:0030546	signaling receptor activator activity	27/822	495/18367	0.168097136489424	0.595462737733721	CXCL14/HGF/BMP5/FGF7/WNT2/STC1/CSF1/SPX/KITLG/FLRT3/GDF6/GAS6/BMP4/TIMP1/IGF2/SEMA3B/GPNMB/MDK/DPP4/CLEC11A/CMTM3/FBN1/BMPR2/BMP1/SEMA6D/METRNL/JAG1	27
GO:0051721	protein phosphatase 2A binding	3/822	32/18367	0.170911294517437	0.597831975801579	MFHAS1/EIF4EBP1/STRN3	3
GO:0071889	14-3-3 protein binding	3/822	32/18367	0.170911294517437	0.597831975801579	SYNPO2/ZFP36L1/HLA-F	3
GO:0140658	ATP-dependent chromatin remodeler activity	3/822	32/18367	0.170911294517437	0.597831975801579	CHD9/ATRX/SHPRH	3
GO:0004725	protein tyrosine phosphatase activity	7/822	102/18367	0.172453439899155	0.600712815648722	PTPRD/PTEN/PTPRK/CDC25B/PTPRG/PTPRA/PTP4A2	7
GO:0015278	calcium-release channel activity	2/822	17/18367	0.175099609200942	0.602400301613116	PKD2/TPCN1	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/822	17/18367	0.175099609200942	0.602400301613116	KMT2A/ASH1L	2
GO:0046965	retinoid X receptor binding	2/822	17/18367	0.175099609200942	0.602400301613116	NCOR2/NCOA1	2
GO:0051018	protein kinase A binding	4/822	51/18367	0.193478607438742	0.65707259784778	AKAP12/PRKAR1A/PJA2/AKAP13	4
GO:0015020	glucuronosyltransferase activity	3/822	34/18367	0.193623881893993	0.65707259784778	CSGALNACT1/EXT1/CHPF2	3
GO:0035198	miRNA binding	3/822	34/18367	0.193623881893993	0.65707259784778	KCNQ1OT1/AGO3/PUM2	3
GO:0003727	single-stranded RNA binding	6/822	87/18367	0.194135085727753	0.65707259784778	PABPC4L/RBMS3/RBMS1/AGO3/ATXN1/ZFR	6
GO:0140375	immune receptor activity	9/822	144/18367	0.196906112023493	0.663764151821129	F3/OSMR/IL1R1/PRLR/CMKLR1/IL6ST/IFNGR2/LIFR/IFNAR1	9
GO:0048306	calcium-dependent protein binding	6/822	88/18367	0.201092360896037	0.672654991263065	A2M/S100A6/S100A4/STX2/SEC31A/VLDLR	6
GO:0048018	receptor ligand activity	26/822	487/18367	0.202193426888141	0.672654991263065	CXCL14/HGF/BMP5/FGF7/WNT2/STC1/CSF1/SPX/KITLG/FLRT3/GDF6/GAS6/BMP4/TIMP1/IGF2/SEMA3B/GPNMB/MDK/DPP4/CLEC11A/CMTM3/FBN1/BMP1/SEMA6D/METRNL/JAG1	26
GO:0004879	nuclear receptor activity	4/822	52/18367	0.202762030859201	0.672654991263065	NR2F1/THRA/NR3C1/STAT3	4
GO:0098531	ligand-activated transcription factor activity	4/822	52/18367	0.202762030859201	0.672654991263065	NR2F1/THRA/NR3C1/STAT3	4
GO:0010314	phosphatidylinositol-5-phosphate binding	2/822	19/18367	0.208030136581339	0.68505742472344	SH3PXD2A/SESTD1	2
GO:0008081	phosphoric diester hydrolase activity	6/822	89/18367	0.208139456793964	0.68505742472344	ENPP1/ENPP2/PDE3A/PDE3B/PLCB1/PLD3	6
GO:0048029	monosaccharide binding	5/822	71/18367	0.211692003008529	0.694017703980903	P4HA2/PLOD2/EGLN3/ENG/IGF2R	5
GO:0000217	DNA secondary structure binding	3/822	36/18367	0.217025524709265	0.703229994794364	HAND2/ABL1/KMT2A	3
GO:0023023	MHC protein complex binding	3/822	36/18367	0.217025524709265	0.703229994794364	ATP1B1/CD81/B2M	3
GO:0097718	disordered domain specific binding	3/822	36/18367	0.217025524709265	0.703229994794364	GJA1/HSPA2/CLTC	3
GO:0003678	DNA helicase activity	5/822	72/18367	0.219816761517135	0.706289156697039	CHD9/ATRX/SETX/RECQL/NAV2	5
GO:0001972	retinoic acid binding	2/822	20/18367	0.224728368039967	0.706289156697039	CRABP1/IGF2R	2
GO:0004551	nucleotide diphosphatase activity	2/822	20/18367	0.224728368039967	0.706289156697039	ENPP1/ENPP2	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/822	20/18367	0.224728368039967	0.706289156697039	VCAM1/LOXL1	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/822	20/18367	0.224728368039967	0.706289156697039	SGMS1/GNPTG	2
GO:0050145	nucleoside monophosphate kinase activity	2/822	20/18367	0.224728368039967	0.706289156697039	CASK/MAGI3	2
GO:0070300	phosphatidic acid binding	2/822	20/18367	0.224728368039967	0.706289156697039	PLTP/SESTD1	2
GO:0097001	ceramide binding	2/822	20/18367	0.224728368039967	0.706289156697039	LAPTM4B/PLTP	2
GO:0008094	ATP-dependent activity, acting on DNA	7/822	111/18367	0.229132194293453	0.717260275352279	CHD9/ATRX/SETX/SHPRH/RECQL/NAV2/BPTF	7
GO:0019903	protein phosphatase binding	9/822	150/18367	0.229935112194271	0.717260275352279	ITGA1/MFHAS1/PIK3R1/EIF4EBP1/HSP90B1/STAT3/FER/STRN3/JAK1	9
GO:0017022	myosin binding	5/822	74/18367	0.236341915982443	0.734504987960305	MYL9/CALD1/SPATA6/AXL/GSN	5
GO:0015631	tubulin binding	20/822	375/18367	0.240289504913559	0.736900023920298	NDN/MAP1B/CRYAB/GJA1/DST/CNN3/PRNP/NDRG1/NIN/CEP44/MAP9/TAOK1/SBDS/EML4/DPYSL2/MAP4K4/CCDC88A/MTUS1/TERF1/MACF1	20
GO:0015175	neutral amino acid transmembrane transporter activity	3/822	38/18367	0.240970197961916	0.736900023920298	SERINC3/SLC38A2/SERINC5	3
GO:0030374	nuclear receptor coactivator activity	4/822	56/18367	0.241086939681782	0.736900023920298	ZMIZ1/ACTN4/MED13/NCOA1	4
GO:0070577	lysine-acetylated histone binding	2/822	21/18367	0.241519864299236	0.736900023920298	MLLT3/KMT2A	2
GO:0140033	acetylation-dependent protein binding	2/822	21/18367	0.241519864299236	0.736900023920298	MLLT3/KMT2A	2
GO:1901981	phosphatidylinositol phosphate binding	10/822	173/18367	0.247730444356409	0.753100550843482	STXBP6/MYO1B/MYO10/LAPTM4B/SH3PXD2A/PLCB1/SESTD1/ASAP1/TPCN1/GSN	10
GO:0004402	histone acetyltransferase activity	3/822	39/18367	0.253102499442658	0.75786447767002	KAT6B/CLOCK/NCOA1	3
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	3/822	39/18367	0.253102499442658	0.75786447767002	MYO1B/MYO10/ASAP1	3
GO:0050997	quaternary ammonium group binding	3/822	39/18367	0.253102499442658	0.75786447767002	PLTP/SCARB2/ESYT2	3
GO:0004602	glutathione peroxidase activity	2/822	22/18367	0.258362890114779	0.75786447767002	GPX7/GPX8	2
GO:0005355	glucose transmembrane transporter activity	2/822	22/18367	0.258362890114779	0.75786447767002	SLC2A10/SLC5A3	2
GO:0005540	hyaluronic acid binding	2/822	22/18367	0.258362890114779	0.75786447767002	HAPLN1/VCAN	2
GO:0008093	cytoskeletal anchor activity	2/822	22/18367	0.258362890114779	0.75786447767002	SORBS2/ABI2	2
GO:0009975	cyclase activity	2/822	22/18367	0.258362890114779	0.75786447767002	GUCY1A2/ADCY3	2
GO:0015149	hexose transmembrane transporter activity	2/822	22/18367	0.258362890114779	0.75786447767002	SLC2A10/SLC5A3	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/822	22/18367	0.258362890114779	0.75786447767002	GAS6/SERPINB9	2
GO:0106310	protein serine kinase activity	19/822	360/18367	0.261638494395057	0.764789445154781	PRKCA/CASK/CDK18/FAM20C/CAMK2D/CDC42BPA/ROCK2/MAP3K8/MAP4K5/TAOK1/HIPK3/DSTYK/WNK1/DAPK1/PRKAA1/MAP4K4/HIPK1/NEK7/ATM	19
GO:0001221	transcription coregulator binding	5/822	78/18367	0.270336738137256	0.779943367861281	ZNF618/EPAS1/KLF4/FOXO3/USP11	5
GO:0030971	receptor tyrosine kinase binding	5/822	78/18367	0.270336738137256	0.779943367861281	GAS6/ANGPT1/IRS1/PIK3R1/FRS2	5
GO:0030695	GTPase regulator activity	25/822	488/18367	0.270595612030627	0.779943367861281	SLIT2/THY1/PREX2/CHN1/ARHGAP5/PLEKHG1/RIN2/FBXO8/PLCB1/DLC1/SBF2/ARHGAP28/ASAP1/PSD3/ACAP2/ARHGAP21/WASL/EVI5/CCDC88A/ARHGEF12/SOS1/AKAP13/ITSN1/FARP1/CHML	25
GO:0060589	nucleoside-triphosphatase regulator activity	25/822	488/18367	0.270595612030627	0.779943367861281	SLIT2/THY1/PREX2/CHN1/ARHGAP5/PLEKHG1/RIN2/FBXO8/PLCB1/DLC1/SBF2/ARHGAP28/ASAP1/PSD3/ACAP2/ARHGAP21/WASL/EVI5/CCDC88A/ARHGEF12/SOS1/AKAP13/ITSN1/FARP1/CHML	25
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/822	23/18367	0.275219250620907	0.779943367861281	PDE3A/PDE3B	2
GO:0005212	structural constituent of eye lens	2/822	23/18367	0.275219250620907	0.779943367861281	CRYAB/VIM	2
GO:0005248	voltage-gated sodium channel activity	2/822	23/18367	0.275219250620907	0.779943367861281	PKD2/TPCN1	2
GO:0016849	phosphorus-oxygen lyase activity	2/822	23/18367	0.275219250620907	0.779943367861281	GUCY1A2/ADCY3	2
GO:0030215	semaphorin receptor binding	2/822	23/18367	0.275219250620907	0.779943367861281	SEMA3B/SEMA6D	2
GO:0016853	isomerase activity	9/822	158/18367	0.276812053458007	0.781404188544213	PTGDS/DSEL/FKBP7/FKBP10/PGM3/PPIC/FKBP9/FKBP14/EBPL	9
GO:0061733	peptide-lysine-N-acetyltransferase activity	3/822	41/18367	0.277604119614392	0.781404188544213	KAT6B/CLOCK/NCOA1	3
GO:0003713	transcription coactivator activity	14/822	262/18367	0.285809508469186	0.801801171410199	MTDH/YAP1/NUPR1/HCFC2/DDX17/LPIN1/ABL1/MAML2/ARID5B/ZMIZ1/NUCKS1/ACTN4/MED13/NCOA1	14
GO:0001965	G-protein alpha-subunit binding	2/822	24/18367	0.292054058669898	0.805799316990213	IGF2R/CCDC88A	2
GO:0008171	O-methyltransferase activity	2/822	24/18367	0.292054058669898	0.805799316990213	TRMT44/ICMT	2
GO:0015145	monosaccharide transmembrane transporter activity	2/822	24/18367	0.292054058669898	0.805799316990213	SLC2A10/SLC5A3	2
GO:0043495	protein-membrane adaptor activity	2/822	24/18367	0.292054058669898	0.805799316990213	SLC9A3R2/SYNE1	2
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	2/822	24/18367	0.292054058669898	0.805799316990213	BMP5/BMP4	2
GO:0005085	guanyl-nucleotide exchange factor activity	12/822	223/18367	0.297516708713428	0.818170948961927	PREX2/PLEKHG1/RIN2/FBXO8/SBF2/PSD3/CCDC88A/ARHGEF12/SOS1/AKAP13/ITSN1/FARP1	12
GO:0016504	peptidase activator activity	3/822	43/18367	0.302317594909674	0.828647571621269	PCOLCE/PCOLCE2/FBLN1	3
GO:0004112	cyclic-nucleotide phosphodiesterase activity	2/822	25/18367	0.308835515865083	0.832859649236159	PDE3A/PDE3B	2
GO:0005112	Notch binding	2/822	25/18367	0.308835515865083	0.832859649236159	NCOR2/JAG1	2
GO:0005227	calcium activated cation channel activity	2/822	25/18367	0.308835515865083	0.832859649236159	KCNMA1/ANO10	2
GO:0008327	methyl-CpG binding	2/822	25/18367	0.308835515865083	0.832859649236159	CXXC5/ZBTB4	2
GO:0051019	mitogen-activated protein kinase binding	2/822	25/18367	0.308835515865083	0.832859649236159	ABL1/NBR1	2
GO:0003697	single-stranded DNA binding	7/822	123/18367	0.312588459074253	0.840269941434326	RBMS1/PURA/FAM111A/RECQL/TERF1/RTF1/NUCKS1	7
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/822	124/18367	0.319814291095392	0.841882429409691	HSD17B2/BDH2/RDH10/ZADH2/UGDH/H6PD/GCLM	7
GO:0097602	cullin family protein binding	2/822	26/18367	0.325534706530293	0.841882429409691	KCTD2/KLHL9	2
GO:0099604	ligand-gated calcium channel activity	2/822	26/18367	0.325534706530293	0.841882429409691	PKD2/TPCN1	2
GO:0003714	transcription corepressor activity	10/822	187/18367	0.327728025746057	0.841882429409691	RUNX1T1/JAZF1/BASP1/NCOR2/LMCD1/YAP1/N4BP2L2/TBL1XR1/ZMYND11/MIER1	10
GO:0005096	GTPase activator activity	23/822	462/18367	0.329028200927226	0.841882429409691	THY1/PREX2/CHN1/ARHGAP5/PLEKHG1/RIN2/FBXO8/PLCB1/DLC1/SBF2/ARHGAP28/ASAP1/PSD3/ACAP2/ARHGAP21/EVI5/CCDC88A/ARHGEF12/SOS1/AKAP13/ITSN1/FARP1/CHML	23
GO:0061980	regulatory RNA binding	3/822	46/18367	0.339531716680674	0.841882429409691	KCNQ1OT1/AGO3/PUM2	3
GO:0004683	calmodulin-dependent protein kinase activity	2/822	27/18367	0.342125403898536	0.841882429409691	CAMK2D/DAPK1	2
GO:0015491	cation:cation antiporter activity	2/822	27/18367	0.342125403898536	0.841882429409691	SLC9A9/SLC8A1	2
GO:0022884	macromolecule transmembrane transporter activity	2/822	27/18367	0.342125403898536	0.841882429409691	SEC61A1/SIDT2	2
GO:0030507	spectrin binding	2/822	27/18367	0.342125403898536	0.841882429409691	EPB41L2/MYO10	2
GO:0035255	ionotropic glutamate receptor binding	2/822	27/18367	0.342125403898536	0.841882429409691	PTEN/CANX	2
GO:0051119	sugar transmembrane transporter activity	2/822	27/18367	0.342125403898536	0.841882429409691	SLC2A10/SLC5A3	2
GO:0001664	G protein-coupled receptor binding	15/822	295/18367	0.343033673056526	0.841882429409691	CXCL14/CTHRC1/WNT2/RSPO3/PALM/EDNRB/SLC9A3R2/BAMBI/FLNA/GNAI1/LRP6/PRNP/STAT3/ARHGEF12/JAK1	15
GO:0019842	vitamin binding	8/822	148/18367	0.343827881113287	0.841882429409691	RBP1/CRABP1/P4HA2/PLOD2/EGLN3/RBP7/OAT/PANK3	8
GO:0031625	ubiquitin protein ligase binding	15/822	297/18367	0.352597748891177	0.841882429409691	LAPTM4B/MFHAS1/PIAS2/SMAD5/CLU/TXNIP/ABI2/PRKAR1A/RTN4/VCL/CCDC50/SHPRH/SKI/LTBR/JAK1	15
GO:0015101	organic cation transmembrane transporter activity	2/822	28/18367	0.358583887840893	0.841882429409691	SLC22A3/SLC19A3	2
GO:0051861	glycolipid binding	2/822	28/18367	0.358583887840893	0.841882429409691	THY1/HSPA2	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/822	28/18367	0.358583887840893	0.841882429409691	SESTD1/TPCN1	2
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	15/822	299/18367	0.362211645088039	0.841882429409691	TCF21/PITX2/GATA6/PITX1/GATA4/NCOR2/MTDH/NOTCH2/KLF4/STAT3/SP3/HSPB1/ACTN4/MED13/NCOA1	15
GO:0016782	transferase activity, transferring sulphur-containing groups	4/822	68/18367	0.362649631662061	0.841882429409691	TPST1/HS3ST6/DSEL/MOCS2	4
GO:0005031	tumor necrosis factor-activated receptor activity	1/822	10/18367	0.367440188138608	0.841882429409691	TNFRSF1A	1
GO:0005432	calcium:sodium antiporter activity	1/822	10/18367	0.367440188138608	0.841882429409691	SLC8A1	1
GO:0008526	phosphatidylinositol transfer activity	1/822	10/18367	0.367440188138608	0.841882429409691	PLTP	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/822	10/18367	0.367440188138608	0.841882429409691	SLC16A10	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/822	10/18367	0.367440188138608	0.841882429409691	MAN1A1	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/822	10/18367	0.367440188138608	0.841882429409691	SH3PXD2A	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/822	10/18367	0.367440188138608	0.841882429409691	ATM	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/822	10/18367	0.367440188138608	0.841882429409691	CYB5R3	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/822	10/18367	0.367440188138608	0.841882429409691	FADS3	1
GO:0016783	sulfurtransferase activity	1/822	10/18367	0.367440188138608	0.841882429409691	MOCS2	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/822	10/18367	0.367440188138608	0.841882429409691	PGM3	1
GO:0019869	chloride channel inhibitor activity	1/822	10/18367	0.367440188138608	0.841882429409691	WNK1	1
GO:0033204	ribonuclease P RNA binding	1/822	10/18367	0.367440188138608	0.841882429409691	RPP25	1
GO:0035612	AP-2 adaptor complex binding	1/822	10/18367	0.367440188138608	0.841882429409691	SIDT2	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/822	10/18367	0.367440188138608	0.841882429409691	PIK3R1	1
GO:0045294	alpha-catenin binding	1/822	10/18367	0.367440188138608	0.841882429409691	VCL	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/822	10/18367	0.367440188138608	0.841882429409691	ASH1L	1
GO:0050786	RAGE receptor binding	1/822	10/18367	0.367440188138608	0.841882429409691	S100A4	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/822	10/18367	0.367440188138608	0.841882429409691	IPMK	1
GO:0070008	serine-type exopeptidase activity	1/822	10/18367	0.367440188138608	0.841882429409691	CTSA	1
GO:0070016	armadillo repeat domain binding	1/822	10/18367	0.367440188138608	0.841882429409691	STRN3	1
GO:0098505	G-rich strand telomeric DNA binding	1/822	10/18367	0.367440188138608	0.841882429409691	TERF1	1
GO:0120016	sphingolipid transfer activity	1/822	10/18367	0.367440188138608	0.841882429409691	PLTP	1
GO:0015297	antiporter activity	5/822	89/18367	0.367724736602401	0.841882429409691	CLCN5/SLC9A9/SLC35E2B/SLC8A1/TMCO3	5
GO:0047485	protein N-terminus binding	6/822	110/18367	0.370113773649082	0.841882429409691	DCN/PDLIM5/NCOR2/TBL1XR1/ATM/NCOA1	6
GO:0015081	sodium ion transmembrane transporter activity	8/822	152/18367	0.371046115003456	0.841882429409691	SLC22A3/ATP1B1/SLC9A9/PKD2/SLC5A3/SLC38A2/TPCN1/SLC8A1	8
GO:0042578	phosphoric ester hydrolase activity	18/822	366/18367	0.374471443760067	0.841882429409691	ENPP1/ENPP2/PDE3A/PTPRD/PLPP1/PLPP3/PTEN/PPM1K/PDE3B/PTPRK/PLCB1/CDC25B/PTPRG/PTPRA/LPIN1/PLD3/PTP4A2/TNS3	18
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/822	29/18367	0.374888773492828	0.841882429409691	BDH2/ZADH2	2
GO:0033612	receptor serine/threonine kinase binding	2/822	29/18367	0.374888773492828	0.841882429409691	BMP5/BMP4	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/822	29/18367	0.374888773492828	0.841882429409691	SH3PXD2A/SESTD1	2
GO:0046625	sphingolipid binding	2/822	29/18367	0.374888773492828	0.841882429409691	LAPTM4B/PLTP	2
GO:0051059	NF-kappaB binding	2/822	29/18367	0.374888773492828	0.841882429409691	MTDH/NOTCH2	2
GO:0051787	misfolded protein binding	2/822	29/18367	0.374888773492828	0.841882429409691	HSPA2/CLU	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/822	29/18367	0.374888773492828	0.841882429409691	SH3PXD2A/SESTD1	2
GO:0034212	peptide N-acetyltransferase activity	3/822	49/18367	0.376606449425806	0.841882429409691	KAT6B/CLOCK/NCOA1	3
GO:0043539	protein serine/threonine kinase activator activity	3/822	49/18367	0.376606449425806	0.841882429409691	IGF2/BMPR2/TAOK1	3
GO:0030159	signaling receptor complex adaptor activity	3/822	50/18367	0.38887923473932	0.841882429409691	IRS1/PIK3R1/FRS2	3
GO:0005217	intracellular ligand-gated ion channel activity	2/822	30/18367	0.391020850169415	0.841882429409691	PKD2/TPCN1	2
GO:0004016	adenylate cyclase activity	1/822	11/18367	0.39576530473446	0.841882429409691	ADCY3	1
GO:0005078	MAP-kinase scaffold activity	1/822	11/18367	0.39576530473446	0.841882429409691	AKAP13	1
GO:0005247	voltage-gated chloride channel activity	1/822	11/18367	0.39576530473446	0.841882429409691	CLCN5	1
GO:0008503	benzodiazepine receptor activity	1/822	11/18367	0.39576530473446	0.841882429409691	TSPO	1
GO:0015368	calcium:cation antiporter activity	1/822	11/18367	0.39576530473446	0.841882429409691	SLC8A1	1
GO:0015378	sodium:chloride symporter activity	1/822	11/18367	0.39576530473446	0.841882429409691	SLC22A3	1
GO:0015386	potassium:proton antiporter activity	1/822	11/18367	0.39576530473446	0.841882429409691	SLC9A9	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/822	11/18367	0.39576530473446	0.841882429409691	SELENBP1	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/822	11/18367	0.39576530473446	0.841882429409691	DDAH2	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/822	11/18367	0.39576530473446	0.841882429409691	DSEL	1
GO:0017128	phospholipid scramblase activity	1/822	11/18367	0.39576530473446	0.841882429409691	PLSCR4	1
GO:0019864	IgG binding	1/822	11/18367	0.39576530473446	0.841882429409691	FCGRT	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/822	11/18367	0.39576530473446	0.841882429409691	HSD17B2	1
GO:0035252	UDP-xylosyltransferase activity	1/822	11/18367	0.39576530473446	0.841882429409691	GXYLT2	1
GO:0035673	oligopeptide transmembrane transporter activity	1/822	11/18367	0.39576530473446	0.841882429409691	GJA1	1
GO:0042285	xylosyltransferase activity	1/822	11/18367	0.39576530473446	0.841882429409691	GXYLT2	1
GO:0042608	T cell receptor binding	1/822	11/18367	0.39576530473446	0.841882429409691	HLA-A	1
GO:0043295	glutathione binding	1/822	11/18367	0.39576530473446	0.841882429409691	GSTM3	1
GO:0043560	insulin receptor substrate binding	1/822	11/18367	0.39576530473446	0.841882429409691	PIK3R1	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/822	11/18367	0.39576530473446	0.841882429409691	ASH1L	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/822	11/18367	0.39576530473446	0.841882429409691	ENPP1	1
GO:0061665	SUMO ligase activity	1/822	11/18367	0.39576530473446	0.841882429409691	PIAS2	1
GO:1901474	azole transmembrane transporter activity	1/822	11/18367	0.39576530473446	0.841882429409691	SLC19A3	1
GO:1990459	transferrin receptor binding	1/822	11/18367	0.39576530473446	0.841882429409691	CD81	1
GO:0004386	helicase activity	8/822	156/18367	0.398420899230709	0.845380385169727	CHD9/DDX17/EIF4A2/ATRX/SETX/SHPRH/RECQL/NAV2	8
GO:0008235	metalloexopeptidase activity	4/822	72/18367	0.403628175715427	0.845705554450694	CPXM1/ANPEP/NPEPPS/LNPEP	4
GO:0043015	gamma-tubulin binding	2/822	31/18367	0.406962929993538	0.845705554450694	NDN/NDRG1	2
GO:0090482	vitamin transmembrane transporter activity	2/822	31/18367	0.406962929993538	0.845705554450694	SLC2A10/SLC19A3	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	7/822	136/18367	0.407918254626543	0.845705554450694	HSD17B2/BDH2/RDH10/ZADH2/UGDH/H6PD/GCLM	7
GO:0016410	N-acyltransferase activity	5/822	94/18367	0.412494052832515	0.845705554450694	KAT6B/CERS2/CERS6/CLOCK/NCOA1	5
GO:0008146	sulfotransferase activity	3/822	52/18367	0.413234411277427	0.845705554450694	TPST1/HS3ST6/DSEL	3
GO:0035064	methylated histone binding	4/822	73/18367	0.413807474204184	0.845705554450694	ATRX/ZMYND11/KMT2E/BPTF	4
GO:0140034	methylation-dependent protein binding	4/822	73/18367	0.413807474204184	0.845705554450694	ATRX/ZMYND11/KMT2E/BPTF	4
GO:0048019	receptor antagonist activity	2/822	32/18367	0.422699705691945	0.845705554450694	FST/DKK3	2
GO:0003964	RNA-directed DNA polymerase activity	1/822	12/18367	0.422823537438114	0.845705554450694	TERF1	1
GO:0004526	ribonuclease P activity	1/822	12/18367	0.422823537438114	0.845705554450694	RPP25	1
GO:0004875	complement receptor activity	1/822	12/18367	0.422823537438114	0.845705554450694	CMKLR1	1
GO:0005095	GTPase inhibitor activity	1/822	12/18367	0.422823537438114	0.845705554450694	SLIT2	1
GO:0008174	mRNA methyltransferase activity	1/822	12/18367	0.422823537438114	0.845705554450694	RNMT	1
GO:0015166	polyol transmembrane transporter activity	1/822	12/18367	0.422823537438114	0.845705554450694	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/822	12/18367	0.422823537438114	0.845705554450694	KCNMA1	1
GO:0015280	ligand-gated sodium channel activity	1/822	12/18367	0.422823537438114	0.845705554450694	TPCN1	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/822	12/18367	0.422823537438114	0.845705554450694	SLC22A3	1
GO:0017166	vinculin binding	1/822	12/18367	0.422823537438114	0.845705554450694	SORBS3	1
GO:0035325	Toll-like receptor binding	1/822	12/18367	0.422823537438114	0.845705554450694	CD36	1
GO:0043047	single-stranded telomeric DNA binding	1/822	12/18367	0.422823537438114	0.845705554450694	TERF1	1
GO:0045295	gamma-catenin binding	1/822	12/18367	0.422823537438114	0.845705554450694	PTPRK	1
GO:1900750	oligopeptide binding	1/822	12/18367	0.422823537438114	0.845705554450694	GSTM3	1
GO:0005254	chloride channel activity	4/822	74/18367	0.423948363245426	0.845705554450694	FXYD1/CLCN5/APOL1/ANO10	4
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/822	53/18367	0.425298046880366	0.845705554450694	SLC22A3/SLC16A7/SLC5A3	3
GO:0019003	GDP binding	4/822	75/18367	0.43404511437988	0.845705554450694	RRAS/GNAI1/RAP2A/RAP2B	4
GO:0008374	O-acyltransferase activity	3/822	54/18367	0.437274125566865	0.845705554450694	LPGAT1/AGPAT2/LPCAT2	3
GO:0015459	potassium channel regulator activity	3/822	54/18367	0.437274125566865	0.845705554450694	FLNA/SLC5A3/WNK1	3
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/822	54/18367	0.437274125566865	0.845705554450694	P4HA2/PLOD2/EGLN3	3
GO:0001530	lipopolysaccharide binding	2/822	33/18367	0.438217617043305	0.845705554450694	SPON2/ZRANB2	2
GO:0005154	epidermal growth factor receptor binding	2/822	33/18367	0.438217617043305	0.845705554450694	FER/CCDC88A	2
GO:0008200	ion channel inhibitor activity	2/822	33/18367	0.438217617043305	0.845705554450694	CAMK2D/WNK1	2
GO:0031369	translation initiation factor binding	2/822	33/18367	0.438217617043305	0.845705554450694	EIF4EBP1/EIF4EBP2	2
GO:0051427	hormone receptor binding	2/822	33/18367	0.438217617043305	0.845705554450694	SOCS2/JAK1	2
GO:0008170	N-methyltransferase activity	5/822	97/18367	0.439149831012548	0.845705554450694	NNMT/INMT/KMT2A/ASH1L/RNMT	5
GO:0004197	cysteine-type endopeptidase activity	6/822	119/18367	0.442445468514656	0.845705554450694	CTSK/CTSO/CAPN2/USP11/USP47/USP9X	6
GO:0044389	ubiquitin-like protein ligase binding	15/822	316/18367	0.445064530730235	0.845705554450694	LAPTM4B/MFHAS1/PIAS2/SMAD5/CLU/TXNIP/ABI2/PRKAR1A/RTN4/VCL/CCDC50/SHPRH/SKI/LTBR/JAK1	15
GO:0004312	fatty acid synthase activity	1/822	13/18367	0.448671483623125	0.845705554450694	ELOVL2	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/822	13/18367	0.448671483623125	0.845705554450694	PPP1R14A	1
GO:0005035	death receptor activity	1/822	13/18367	0.448671483623125	0.845705554450694	TNFRSF1A	1
GO:0008179	adenylate cyclase binding	1/822	13/18367	0.448671483623125	0.845705554450694	AKAP12	1
GO:0015271	outward rectifier potassium channel activity	1/822	13/18367	0.448671483623125	0.845705554450694	PKD2	1
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	1/822	13/18367	0.448671483623125	0.845705554450694	SLC16A7	1
GO:0015385	sodium:proton antiporter activity	1/822	13/18367	0.448671483623125	0.845705554450694	SLC9A9	1
GO:0031432	titin binding	1/822	13/18367	0.448671483623125	0.845705554450694	CAMK2D	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/822	13/18367	0.448671483623125	0.845705554450694	AMFR	1
GO:0045159	myosin II binding	1/822	13/18367	0.448671483623125	0.845705554450694	GSN	1
GO:0052650	NADP-retinol dehydrogenase activity	1/822	13/18367	0.448671483623125	0.845705554450694	RDH10	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/822	13/18367	0.448671483623125	0.845705554450694	HSD17B2	1
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/822	55/18367	0.44915462461257	0.845705554450694	GPX7/SESN3/GPX8	3
GO:0016248	channel inhibitor activity	2/822	34/18367	0.453504725490137	0.850067153609316	CAMK2D/WNK1	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/822	34/18367	0.453504725490137	0.850067153609316	RPP25/AGO3	2
GO:0008194	UDP-glycosyltransferase activity	7/822	143/18367	0.459313744235047	0.851753777166067	GXYLT2/CSGALNACT1/CSGALNACT2/EXT1/COLGALT1/GALNT1/CHPF2	7
GO:0042054	histone methyltransferase activity	3/822	56/18367	0.460932040740727	0.851753777166067	PRDM6/KMT2A/ASH1L	3
GO:0051287	NAD binding	3/822	56/18367	0.460932040740727	0.851753777166067	BDH2/UGDH/CYB5R3	3
GO:0051082	unfolded protein binding	6/822	122/18367	0.466261794091984	0.851753777166067	CRYAB/HSPA2/CLU/SERPINH1/HSP90B1/CANX	6
GO:0004065	arylsulfatase activity	1/822	14/18367	0.473363215150955	0.851753777166067	SULF2	1
GO:0005172	vascular endothelial growth factor receptor binding	1/822	14/18367	0.473363215150955	0.851753777166067	CCDC88A	1
GO:0005451	monovalent cation:proton antiporter activity	1/822	14/18367	0.473363215150955	0.851753777166067	SLC9A9	1
GO:0015373	anion:sodium symporter activity	1/822	14/18367	0.473363215150955	0.851753777166067	SLC22A3	1
GO:0015562	efflux transmembrane transporter activity	1/822	14/18367	0.473363215150955	0.851753777166067	GJA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/822	14/18367	0.473363215150955	0.851753777166067	EBPL	1
GO:0019992	diacylglycerol binding	1/822	14/18367	0.473363215150955	0.851753777166067	PLTP	1
GO:0043023	ribosomal large subunit binding	1/822	14/18367	0.473363215150955	0.851753777166067	LTN1	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/822	14/18367	0.473363215150955	0.851753777166067	HSD17B2	1
GO:0070411	I-SMAD binding	1/822	14/18367	0.473363215150955	0.851753777166067	SMAD5	1
GO:0071837	HMG box domain binding	1/822	14/18367	0.473363215150955	0.851753777166067	TCF12	1
GO:0140666	annealing activity	1/822	14/18367	0.473363215150955	0.851753777166067	RECQL	1
GO:0030295	protein kinase activator activity	5/822	101/18367	0.474224499095008	0.851753777166067	GAS6/IGF2/BMPR2/TAOK1/WNK1	5
GO:0034061	DNA polymerase activity	2/822	36/18367	0.483346188908246	0.851753777166067	REV3L/TERF1	2
GO:0042162	telomeric DNA binding	2/822	36/18367	0.483346188908246	0.851753777166067	PURA/TERF1	2
GO:0031490	chromatin DNA binding	5/822	103/18367	0.491497068808552	0.851753777166067	THRA/FOXO3/STAT3/ACTN4/CLOCK	5
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/822	15/18367	0.496950390933983	0.851753777166067	ALDH9A1	1
GO:0004549	tRNA-specific ribonuclease activity	1/822	15/18367	0.496950390933983	0.851753777166067	RPP25	1
GO:0004559	alpha-mannosidase activity	1/822	15/18367	0.496950390933983	0.851753777166067	MAN1A1	1
GO:0008559	ABC-type xenobiotic transporter activity	1/822	15/18367	0.496950390933983	0.851753777166067	ABCA8	1
GO:0016805	dipeptidase activity	1/822	15/18367	0.496950390933983	0.851753777166067	SCRN1	1
GO:0016846	carbon-sulfur lyase activity	1/822	15/18367	0.496950390933983	0.851753777166067	GLO1	1
GO:0019215	intermediate filament binding	1/822	15/18367	0.496950390933983	0.851753777166067	VIM	1
GO:0030553	cGMP binding	1/822	15/18367	0.496950390933983	0.851753777166067	PRKG1	1
GO:0032794	GTPase activating protein binding	1/822	15/18367	0.496950390933983	0.851753777166067	GNAI1	1
GO:0034483	heparan sulfate sulfotransferase activity	1/822	15/18367	0.496950390933983	0.851753777166067	HS3ST6	1
GO:0042043	neurexin family protein binding	1/822	15/18367	0.496950390933983	0.851753777166067	CASK	1
GO:0042809	vitamin D receptor binding	1/822	15/18367	0.496950390933983	0.851753777166067	MED13	1
GO:0045125	bioactive lipid receptor activity	1/822	15/18367	0.496950390933983	0.851753777166067	LPAR1	1
GO:0051139	metal ion:proton antiporter activity	1/822	15/18367	0.496950390933983	0.851753777166067	SLC9A9	1
GO:0070742	C2H2 zinc finger domain binding	1/822	15/18367	0.496950390933983	0.851753777166067	EBF1	1
GO:0098847	sequence-specific single stranded DNA binding	1/822	15/18367	0.496950390933983	0.851753777166067	TERF1	1
GO:1901611	phosphatidylglycerol binding	1/822	15/18367	0.496950390933983	0.851753777166067	PLTP	1
GO:1904680	peptide transmembrane transporter activity	1/822	15/18367	0.496950390933983	0.851753777166067	GJA1	1
GO:0030551	cyclic nucleotide binding	2/822	37/18367	0.497883751821308	0.851753777166067	PRKG1/PRKAR1A	2
GO:0071949	FAD binding	2/822	37/18367	0.497883751821308	0.851753777166067	STEAP4/CYB5R3	2
GO:0015291	secondary active transmembrane transporter activity	11/822	240/18367	0.511496507288679	0.851753777166067	SLC16A10/SLC22A3/CLCN5/SLC2A10/SLC16A7/SLC9A9/SLC5A3/SLC38A2/SLC35E2B/SLC8A1/TMCO3	11
GO:0019213	deacetylase activity	2/822	38/18367	0.512156727035718	0.851753777166067	CES1/MIER1	2
GO:0005507	copper ion binding	3/822	61/18367	0.518044855760656	0.851753777166067	LOXL1/SOD3/PRNP	3
GO:0015179	L-amino acid transmembrane transporter activity	3/822	61/18367	0.518044855760656	0.851753777166067	SERINC3/SLC38A2/SERINC5	3
GO:0043621	protein self-association	3/822	61/18367	0.518044855760656	0.851753777166067	ACVR2A/PLEC/ATXN1	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/822	16/18367	0.519482364487397	0.851753777166067	PURA	1
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/822	16/18367	0.519482364487397	0.851753777166067	ALDH9A1	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/822	16/18367	0.519482364487397	0.851753777166067	CAPN2	1
GO:0004698	calcium-dependent protein kinase C activity	1/822	16/18367	0.519482364487397	0.851753777166067	PRKCA	1
GO:0005283	amino acid:sodium symporter activity	1/822	16/18367	0.519482364487397	0.851753777166067	SLC38A2	1
GO:0015923	mannosidase activity	1/822	16/18367	0.519482364487397	0.851753777166067	MAN1A1	1
GO:0016208	AMP binding	1/822	16/18367	0.519482364487397	0.851753777166067	CYB5R3	1
GO:0022821	potassium ion antiporter activity	1/822	16/18367	0.519482364487397	0.851753777166067	SLC9A9	1
GO:0047498	calcium-dependent phospholipase A2 activity	1/822	16/18367	0.519482364487397	0.851753777166067	PLA2G2A	1
GO:0050135	NAD(P)+ nucleosidase activity	1/822	16/18367	0.519482364487397	0.851753777166067	IL1R1	1
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	1/822	16/18367	0.519482364487397	0.851753777166067	IL1R1	1
GO:0070492	oligosaccharide binding	1/822	16/18367	0.519482364487397	0.851753777166067	LGALS1	1
GO:1990380	Lys48-specific deubiquitinase activity	1/822	16/18367	0.519482364487397	0.851753777166067	USP9X	1
GO:0004721	phosphoprotein phosphatase activity	8/822	174/18367	0.520064075311819	0.851753777166067	PTPRD/PTEN/PPM1K/PTPRK/CDC25B/PTPRG/PTPRA/PTP4A2	8
GO:0015171	amino acid transmembrane transporter activity	4/822	84/18367	0.522099805558927	0.851753777166067	SLC16A10/SERINC3/SLC38A2/SERINC5	4
GO:0019209	kinase activator activity	5/822	107/18367	0.525384996465631	0.851753777166067	GAS6/IGF2/BMPR2/TAOK1/WNK1	5
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/822	39/18367	0.526159658256965	0.851753777166067	CASK/MAGI3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	10/822	222/18367	0.537367775996049	0.851753777166067	ELOVL2/KAT6B/LPGAT1/AGPAT2/LPCAT2/CERS2/CERS6/ZDHHC21/CLOCK/NCOA1	10
GO:0003925	G protein activity	2/822	40/18367	0.539888105776207	0.851753777166067	RAP2A/RAP2B	2
GO:0015144	carbohydrate transmembrane transporter activity	2/822	40/18367	0.539888105776207	0.851753777166067	SLC2A10/SLC5A3	2
GO:0017080	sodium channel regulator activity	2/822	40/18367	0.539888105776207	0.851753777166067	FXYD1/CAMK2D	2
GO:0043014	alpha-tubulin binding	2/822	40/18367	0.539888105776207	0.851753777166067	TAOK1/EML4	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/822	40/18367	0.539888105776207	0.851753777166067	GAS6/SERPINB9	2
GO:0044183	protein folding chaperone	2/822	40/18367	0.539888105776207	0.851753777166067	HSPA2/HSPB1	2
GO:0016209	antioxidant activity	4/822	86/18367	0.540790479532881	0.851753777166067	APOE/SOD3/GPX7/GPX8	4
GO:0000400	four-way junction DNA binding	1/822	17/18367	0.541006286692801	0.851753777166067	ABL1	1
GO:0003951	NAD+ kinase activity	1/822	17/18367	0.541006286692801	0.851753777166067	NADK2	1
GO:0004697	protein kinase C activity	1/822	17/18367	0.541006286692801	0.851753777166067	PRKCA	1
GO:0005005	transmembrane-ephrin receptor activity	1/822	17/18367	0.541006286692801	0.851753777166067	EPHA3	1
GO:0005324	long-chain fatty acid transporter activity	1/822	17/18367	0.541006286692801	0.851753777166067	CD36	1
GO:0008308	voltage-gated anion channel activity	1/822	17/18367	0.541006286692801	0.851753777166067	CLCN5	1
GO:0008381	mechanosensitive ion channel activity	1/822	17/18367	0.541006286692801	0.851753777166067	PIEZO1	1
GO:0008484	sulfuric ester hydrolase activity	1/822	17/18367	0.541006286692801	0.851753777166067	SULF2	1
GO:0008525	phosphatidylcholine transporter activity	1/822	17/18367	0.541006286692801	0.851753777166067	PLTP	1
GO:0015377	cation:chloride symporter activity	1/822	17/18367	0.541006286692801	0.851753777166067	SLC22A3	1
GO:0016854	racemase and epimerase activity	1/822	17/18367	0.541006286692801	0.851753777166067	DSEL	1
GO:0017081	chloride channel regulator activity	1/822	17/18367	0.541006286692801	0.851753777166067	WNK1	1
GO:0030275	LRR domain binding	1/822	17/18367	0.541006286692801	0.851753777166067	ROBO1	1
GO:0050780	dopamine receptor binding	1/822	17/18367	0.541006286692801	0.851753777166067	PALM	1
GO:0052745	inositol phosphate phosphatase activity	1/822	17/18367	0.541006286692801	0.851753777166067	PTEN	1
GO:0016779	nucleotidyltransferase activity	6/822	132/18367	0.543272888847192	0.853714539617016	PAPSS2/REV3L/ABL1/TERF1/UAP1/PAPSS1	6
GO:0005253	anion channel activity	4/822	87/18367	0.549994795449918	0.858263587811106	FXYD1/CLCN5/APOL1/ANO10	4
GO:0000149	SNARE binding	5/822	110/18367	0.550138302013881	0.858263587811106	STX2/ABL1/TPCN1/DAPK1/TNFAIP2	5
GO:0048487	beta-tubulin binding	2/822	41/18367	0.553338566605019	0.858263587811106	TAOK1/EML4	2
GO:0008276	protein methyltransferase activity	4/822	88/18367	0.55910124897398	0.858263587811106	PRDM6/KMT2A/ASH1L/ICMT	4
GO:0030145	manganese ion binding	3/822	65/18367	0.561290734720166	0.858263587811106	FAM20C/ABL1/GALNT1	3
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/822	18/18367	0.561567203986453	0.858263587811106	HSD17B2	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/822	18/18367	0.561567203986453	0.858263587811106	PTEN	1
GO:0005229	intracellular calcium activated chloride channel activity	1/822	18/18367	0.561567203986453	0.858263587811106	ANO10	1
GO:0008301	DNA binding, bending	1/822	18/18367	0.561567203986453	0.858263587811106	TERF1	1
GO:0008409	5'-3' exonuclease activity	1/822	18/18367	0.561567203986453	0.858263587811106	PLD3	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/822	18/18367	0.561567203986453	0.858263587811106	TGFBR2	1
GO:0046624	sphingolipid transporter activity	1/822	18/18367	0.561567203986453	0.858263587811106	PLTP	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/822	18/18367	0.561567203986453	0.858263587811106	GCLM	1
GO:0061778	intracellular chloride channel activity	1/822	18/18367	0.561567203986453	0.858263587811106	ANO10	1
GO:0140597	protein carrier activity	1/822	18/18367	0.561567203986453	0.858263587811106	CLU	1
GO:0043177	organic acid binding	6/822	135/18367	0.565427622639409	0.858318613630019	CRABP1/P4HA2/PLOD2/EGLN3/IGF2R/DDAH2	6
GO:0001046	core promoter sequence-specific DNA binding	2/822	42/18367	0.566508399708308	0.858318613630019	NR3C1/SNAPC3	2
GO:0019205	nucleobase-containing compound kinase activity	2/822	42/18367	0.566508399708308	0.858318613630019	CASK/MAGI3	2
GO:0019888	protein phosphatase regulator activity	4/822	89/18367	0.568107202497348	0.858318613630019	IGFBP3/PHACTR2/PPP1R14A/PPP2R5E	4
GO:0140097	catalytic activity, acting on DNA	10/822	229/18367	0.577207952142264	0.858318613630019	CHD9/REV3L/PLD3/ATRX/SETX/SHPRH/RECQL/NAV2/TERF1/BPTF	10
GO:0016791	phosphatase activity	12/822	275/18367	0.577494044135417	0.858318613630019	PTPRD/PLPP1/PLPP3/PTEN/PPM1K/PTPRK/CDC25B/PTPRG/PTPRA/LPIN1/PTP4A2/TNS3	12
GO:0140030	modification-dependent protein binding	7/822	160/18367	0.578546141611929	0.858318613630019	MLLT3/KMT2A/ATRX/ZMYND11/RNF169/KMT2E/BPTF	7
GO:0004180	carboxypeptidase activity	2/822	43/18367	0.579395756039949	0.858318613630019	CPXM1/CTSA	2
GO:0018024	histone-lysine N-methyltransferase activity	2/822	43/18367	0.579395756039949	0.858318613630019	KMT2A/ASH1L	2
GO:0030547	signaling receptor inhibitor activity	2/822	43/18367	0.579395756039949	0.858318613630019	FST/DKK3	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/822	43/18367	0.579395756039949	0.858318613630019	SH3PXD2A/SESTD1	2
GO:0000339	RNA cap binding	1/822	19/18367	0.581208152175626	0.858318613630019	EIF4G3	1
GO:0004129	cytochrome-c oxidase activity	1/822	19/18367	0.581208152175626	0.858318613630019	COX7A1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/822	19/18367	0.581208152175626	0.858318613630019	GALNT1	1
GO:0004745	NAD-retinol dehydrogenase activity	1/822	19/18367	0.581208152175626	0.858318613630019	RDH10	1
GO:0005003	ephrin receptor activity	1/822	19/18367	0.581208152175626	0.858318613630019	EPHA3	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/822	19/18367	0.581208152175626	0.858318613630019	SLC22A3	1
GO:0052742	phosphatidylinositol kinase activity	1/822	19/18367	0.581208152175626	0.858318613630019	ATM	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/822	19/18367	0.581208152175626	0.858318613630019	PTEN	1
GO:0003774	cytoskeletal motor activity	5/822	114/18367	0.582137145847154	0.858318613630019	MYO1B/MYO10/MYO1E/KLC1/MYO1C	5
GO:0016407	acetyltransferase activity	4/822	91/18367	0.58580802079698	0.862210396806822	KAT6B/LPCAT2/CLOCK/NCOA1	4
GO:0008514	organic anion transmembrane transporter activity	8/822	185/18367	0.590134269404738	0.863296257694996	SLC22A3/CD36/GJA1/SLC2A10/SLC16A7/SERINC3/SLC38A2/SERINC5	8
GO:0022839	ion gated channel activity	2/822	44/18367	0.591999513101789	0.863296257694996	KCNMA1/ANO10	2
GO:0008080	N-acetyltransferase activity	3/822	68/18367	0.592135271961024	0.863296257694996	KAT6B/CLOCK/NCOA1	3
GO:0020037	heme binding	6/822	139/18367	0.594138315575353	0.863296257694996	GUCY1A2/STEAP4/CYP20A1/PGRMC1/BACH1/HEBP1	6
GO:0099106	ion channel regulator activity	6/822	139/18367	0.594138315575353	0.863296257694996	FXYD1/PRKG1/FLNA/CAMK2D/SLC5A3/WNK1	6
GO:0043130	ubiquitin binding	4/822	92/18367	0.594498557399807	0.863296257694996	AMFR/NBR1/STAM2/HSPB1	4
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/822	20/18367	0.599970246077503	0.863296257694996	TCF4	1
GO:0016018	cyclosporin A binding	1/822	20/18367	0.599970246077503	0.863296257694996	PPIC	1
GO:0016500	protein-hormone receptor activity	1/822	20/18367	0.599970246077503	0.863296257694996	CMKLR1	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/822	20/18367	0.599970246077503	0.863296257694996	COX7A1	1
GO:0030296	protein tyrosine kinase activator activity	1/822	20/18367	0.599970246077503	0.863296257694996	GAS6	1
GO:0031681	G-protein beta-subunit binding	1/822	20/18367	0.599970246077503	0.863296257694996	GNG11	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/822	20/18367	0.599970246077503	0.863296257694996	GNAI1	1
GO:0005245	voltage-gated calcium channel activity	2/822	45/18367	0.604319213762097	0.866570948036214	PKD2/TPCN1	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/822	45/18367	0.604319213762097	0.866570948036214	RPP25/AGO3	2
GO:0005125	cytokine activity	10/822	235/18367	0.610127538441646	0.870630376870776	CXCL14/BMP5/WNT2/CSF1/KITLG/GDF6/BMP4/TIMP1/CMTM3/BMP1	10
GO:0004864	protein phosphatase inhibitor activity	2/822	46/18367	0.61635500908398	0.870630376870776	PHACTR2/PPP1R14A	2
GO:0005272	sodium channel activity	2/822	46/18367	0.61635500908398	0.870630376870776	PKD2/TPCN1	2
GO:0140296	general transcription initiation factor binding	2/822	46/18367	0.61635500908398	0.870630376870776	TCF4/THRA	2
GO:0004407	histone deacetylase activity	1/822	21/18367	0.617892765166416	0.870630376870776	MIER1	1
GO:0005243	gap junction channel activity	1/822	21/18367	0.617892765166416	0.870630376870776	GJA1	1
GO:0015662	P-type ion transporter activity	1/822	21/18367	0.617892765166416	0.870630376870776	ATP1B1	1
GO:0051010	microtubule plus-end binding	1/822	21/18367	0.617892765166416	0.870630376870776	DST	1
GO:0140358	P-type transmembrane transporter activity	1/822	21/18367	0.617892765166416	0.870630376870776	ATP1B1	1
GO:0140416	transcription regulator inhibitor activity	1/822	21/18367	0.617892765166416	0.870630376870776	PURA	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/822	47/18367	0.628107604928094	0.870630376870776	PTEN/PTP4A2	2
GO:0016922	nuclear receptor binding	6/822	144/18367	0.628565384047787	0.870630376870776	TCF21/NCOR2/STAT3/ACTN4/MED13/NCOA1	6
GO:0042379	chemokine receptor binding	3/822	72/18367	0.631015557707856	0.870630376870776	CXCL14/STAT3/JAK1	3
GO:0005416	amino acid:cation symporter activity	1/822	22/18367	0.63501323540697	0.870630376870776	SLC38A2	1
GO:0005537	mannose binding	1/822	22/18367	0.63501323540697	0.870630376870776	IGF2R	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/822	22/18367	0.63501323540697	0.870630376870776	RDH10	1
GO:0008320	protein transmembrane transporter activity	1/822	22/18367	0.63501323540697	0.870630376870776	SEC61A1	1
GO:0015296	anion:cation symporter activity	1/822	22/18367	0.63501323540697	0.870630376870776	SLC22A3	1
GO:0016881	acid-amino acid ligase activity	1/822	22/18367	0.63501323540697	0.870630376870776	GCLM	1
GO:0017075	syntaxin-1 binding	1/822	22/18367	0.63501323540697	0.870630376870776	DAPK1	1
GO:0033558	protein deacetylase activity	1/822	22/18367	0.63501323540697	0.870630376870776	MIER1	1
GO:0072349	modified amino acid transmembrane transporter activity	1/822	22/18367	0.63501323540697	0.870630376870776	GJA1	1
GO:0016247	channel regulator activity	6/822	145/18367	0.63524404763911	0.870630376870776	FXYD1/PRKG1/FLNA/CAMK2D/SLC5A3/WNK1	6
GO:0048020	CCR chemokine receptor binding	2/822	48/18367	0.639578212106971	0.870630376870776	STAT3/JAK1	2
GO:0015370	solute:sodium symporter activity	3/822	73/18367	0.640324475572298	0.870630376870776	SLC22A3/SLC5A3/SLC38A2	3
GO:0033293	monocarboxylic acid binding	3/822	73/18367	0.640324475572298	0.870630376870776	PTGDS/CRABP1/IGF2R	3
GO:0070063	RNA polymerase binding	3/822	73/18367	0.640324475572298	0.870630376870776	BIN1/STOM/RTF1	3
GO:0005179	hormone activity	5/822	122/18367	0.64225087216991	0.870630376870776	STC1/SPX/IGF2/FBN1/METRNL	5
GO:0003823	antigen binding	7/822	171/18367	0.648475950845224	0.870630376870776	MFAP4/SPON2/HLA-B/TSPAN4/HLA-A/HLA-C/HLA-F	7
GO:0019905	syntaxin binding	3/822	74/18367	0.649467128205828	0.870630376870776	ABL1/TPCN1/DAPK1	3
GO:0019212	phosphatase inhibitor activity	2/822	49/18367	0.650768499880638	0.870630376870776	PHACTR2/PPP1R14A	2
GO:0004529	exodeoxyribonuclease activity	1/822	23/18367	0.651367507442701	0.870630376870776	PLD3	1
GO:0008483	transaminase activity	1/822	23/18367	0.651367507442701	0.870630376870776	OAT	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/822	23/18367	0.651367507442701	0.870630376870776	PRKCA	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/822	23/18367	0.651367507442701	0.870630376870776	PLD3	1
GO:0017025	TBP-class protein binding	1/822	23/18367	0.651367507442701	0.870630376870776	THRA	1
GO:0019865	immunoglobulin binding	1/822	23/18367	0.651367507442701	0.870630376870776	FCGRT	1
GO:0030552	cAMP binding	1/822	23/18367	0.651367507442701	0.870630376870776	PRKAR1A	1
GO:0070412	R-SMAD binding	1/822	23/18367	0.651367507442701	0.870630376870776	LDLRAD4	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/822	23/18367	0.651367507442701	0.870630376870776	RNF169	1
GO:0008509	anion transmembrane transporter activity	13/822	314/18367	0.653056149985669	0.870630376870776	SLC22A3/FXYD1/CD36/GJA1/CLCN5/SLC2A10/SLC16A7/SLC9A9/APOL1/ANO10/SERINC3/SLC38A2/SERINC5	13
GO:0022853	active ion transmembrane transporter activity	11/822	267/18367	0.653681088980434	0.870630376870776	SLC22A3/CLCN5/SLC2A10/SLC16A7/ATP1B1/SLC9A9/COX7A1/SLC5A3/SLC38A2/SLC8A1/TMCO3	11
GO:0042393	histone binding	10/822	244/18367	0.657011996966725	0.870630376870776	MLLT3/KAT6B/RSF1/KMT2A/TBL1XR1/PHF10/ATRX/ZMYND11/KMT2E/BPTF	10
GO:0046906	tetrapyrrole binding	6/822	149/18367	0.66123812611215	0.870630376870776	GUCY1A2/STEAP4/CYP20A1/PGRMC1/BACH1/HEBP1	6
GO:0005048	signal sequence binding	2/822	50/18367	0.661680552594859	0.870630376870776	SEC61A1/AP2B1	2
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	2/822	50/18367	0.661680552594859	0.870630376870776	CCND2/CCNG2	2
GO:0140359	ABC-type transporter activity	2/822	50/18367	0.661680552594859	0.870630376870776	ABCA8/ABCA5	2
GO:0000030	mannosyltransferase activity	1/822	24/18367	0.666989831302388	0.870630376870776	DPY19L4	1
GO:0003707	steroid hormone receptor activity	1/822	24/18367	0.666989831302388	0.870630376870776	NR3C1	1
GO:0004622	lysophospholipase activity	1/822	24/18367	0.666989831302388	0.870630376870776	ENPP2	1
GO:0010857	calcium-dependent protein kinase activity	1/822	24/18367	0.666989831302388	0.870630376870776	PRKCA	1
GO:0015295	solute:proton symporter activity	1/822	24/18367	0.666989831302388	0.870630376870776	SLC2A10	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/822	24/18367	0.666989831302388	0.870630376870776	OAT	1
GO:0019789	SUMO transferase activity	1/822	24/18367	0.666989831302388	0.870630376870776	PIAS2	1
GO:0019957	C-C chemokine binding	1/822	24/18367	0.666989831302388	0.870630376870776	ACKR1	1
GO:0043274	phospholipase binding	1/822	24/18367	0.666989831302388	0.870630376870776	PLA2R1	1
GO:0120014	phospholipid transfer activity	1/822	24/18367	0.666989831302388	0.870630376870776	PLTP	1
GO:0140677	molecular function activator activity	6/822	150/18367	0.66755271719398	0.870630376870776	APOE/ATP1B1/SH3PXD2A/NUPR1/BMPR2/CTSA	6
GO:0003743	translation initiation factor activity	2/822	51/18367	0.672316829274421	0.872759113778596	EIF4G3/EIF4A2	2
GO:0004601	peroxidase activity	2/822	51/18367	0.672316829274421	0.872759113778596	GPX7/GPX8	2
GO:0016860	intramolecular oxidoreductase activity	2/822	51/18367	0.672316829274421	0.872759113778596	PTGDS/EBPL	2
GO:0031406	carboxylic acid binding	7/822	176/18367	0.677891002501199	0.87863081874574	PTGDS/CRABP1/P4HA2/PLOD2/SESN3/EGLN3/IGF2R	7
GO:0003887	DNA-directed DNA polymerase activity	1/822	25/18367	0.681912927778942	0.879384569077404	REV3L	1
GO:0034237	protein kinase A regulatory subunit binding	1/822	25/18367	0.681912927778942	0.879384569077404	PJA2	1
GO:0120227	acyl-CoA binding	1/822	25/18367	0.681912927778942	0.879384569077404	PANK3	1
GO:1901682	sulfur compound transmembrane transporter activity	2/822	52/18367	0.6826801259943	0.879384569077404	GJA1/SLC19A3	2
GO:0016746	acyltransferase activity	10/822	250/18367	0.686425804269205	0.879786204552714	ELOVL2/KAT6B/LPGAT1/AGPAT2/LPCAT2/CERS2/CERS6/ZDHHC21/CLOCK/NCOA1	10
GO:0004620	phospholipase activity	4/822	104/18367	0.689891401734028	0.879786204552714	ENPP2/PLA2G2A/PLCB1/PLD3	4
GO:0015294	solute:cation symporter activity	4/822	104/18367	0.689891401734028	0.879786204552714	SLC22A3/SLC2A10/SLC5A3/SLC38A2	4
GO:0016298	lipase activity	5/822	129/18367	0.690194337700626	0.879786204552714	ENPP2/PLA2G2A/CES1/PLCB1/PLD3	5
GO:0001637	G protein-coupled chemoattractant receptor activity	1/822	26/18367	0.696168056628888	0.879786204552714	CMKLR1	1
GO:0004364	glutathione transferase activity	1/822	26/18367	0.696168056628888	0.879786204552714	GSTM3	1
GO:0004435	phosphatidylinositol phospholipase C activity	1/822	26/18367	0.696168056628888	0.879786204552714	PLCB1	1
GO:0004950	chemokine receptor activity	1/822	26/18367	0.696168056628888	0.879786204552714	CMKLR1	1
GO:0008198	ferrous iron binding	1/822	26/18367	0.696168056628888	0.879786204552714	EGLN3	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/822	26/18367	0.696168056628888	0.879786204552714	ZDHHC21	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/822	26/18367	0.696168056628888	0.879786204552714	ZDHHC21	1
GO:0038187	pattern recognition receptor activity	1/822	26/18367	0.696168056628888	0.879786204552714	CD36	1
GO:0015078	proton transmembrane transporter activity	5/822	130/18367	0.696672807911359	0.879786204552714	CLCN5/SLC2A10/SLC9A9/COX7A1/TMCO3	5
GO:0004527	exonuclease activity	3/822	80/18367	0.700820257707037	0.883688892071014	ENPP1/ENPP2/PLD3	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	6/822	156/18367	0.703851487939052	0.884322396914369	NNMT/INMT/KMT2A/ASH1L/RNMT/ICMT	6
GO:0019001	guanyl nucleotide binding	16/822	398/18367	0.70609157286629	0.884322396914369	GUCY1A2/EHD2/PRKG1/MFHAS1/RND3/RRAS/RAB23/ARHGAP5/GNAI1/RAP2A/NIN/RHOQ/RAP2B/DAPK1/SAR1A/ATL3	16
GO:0032561	guanyl ribonucleotide binding	16/822	398/18367	0.70609157286629	0.884322396914369	GUCY1A2/EHD2/PRKG1/MFHAS1/RND3/RRAS/RAB23/ARHGAP5/GNAI1/RAP2A/NIN/RHOQ/RAP2B/DAPK1/SAR1A/ATL3	16
GO:0001671	ATPase activator activity	1/822	27/18367	0.709785081733902	0.884322396914369	ATP1B1	1
GO:0004709	MAP kinase kinase kinase activity	1/822	27/18367	0.709785081733902	0.884322396914369	MAP3K8	1
GO:0016866	intramolecular transferase activity	1/822	27/18367	0.709785081733902	0.884322396914369	PGM3	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/822	27/18367	0.709785081733902	0.884322396914369	PTEN	1
GO:0051959	dynein light intermediate chain binding	1/822	27/18367	0.709785081733902	0.884322396914369	CCDC88A	1
GO:0005525	GTP binding	15/822	377/18367	0.716672929147829	0.891575251142239	GUCY1A2/EHD2/MFHAS1/RND3/RRAS/RAB23/ARHGAP5/GNAI1/RAP2A/NIN/RHOQ/RAP2B/DAPK1/SAR1A/ATL3	15
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/822	56/18367	0.721469338011937	0.892547352863515	GAS6/SERPINB9	2
GO:0003785	actin monomer binding	1/822	28/18367	0.722792533359569	0.892547352863515	ABL1	1
GO:0003953	NAD+ nucleosidase activity	1/822	28/18367	0.722792533359569	0.892547352863515	IL1R1	1
GO:0004629	phospholipase C activity	1/822	28/18367	0.722792533359569	0.892547352863515	PLCB1	1
GO:0050681	androgen receptor binding	1/822	28/18367	0.722792533359569	0.892547352863515	TCF21	1
GO:0015085	calcium ion transmembrane transporter activity	5/822	135/18367	0.727655894795171	0.894519699887161	PKD1/PKD2/SEC61A1/TPCN1/SLC8A1	5
GO:0005548	phospholipid transporter activity	2/822	57/18367	0.730519154796822	0.894519699887161	PLSCR4/PLTP	2
GO:0008047	enzyme activator activity	4/822	110/18367	0.73118432860209	0.894519699887161	APOE/SH3PXD2A/NUPR1/CTSA	4
GO:0022804	active transmembrane transporter activity	16/822	406/18367	0.734789578259251	0.894519699887161	SLC16A10/SLC22A3/ABCA8/CLCN5/CYBRD1/SLC2A10/SLC16A7/ATP1B1/SLC9A9/COX7A1/SLC5A3/SLC38A2/SLC35E2B/SLC8A1/TMCO3/ABCA5	16
GO:0004033	aldo-keto reductase (NADP) activity	1/822	29/18367	0.735217667640524	0.894519699887161	RDH10	1
GO:0004181	metallocarboxypeptidase activity	1/822	29/18367	0.735217667640524	0.894519699887161	CPXM1	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/822	29/18367	0.735217667640524	0.894519699887161	CDK18	1
GO:0035250	UDP-galactosyltransferase activity	1/822	29/18367	0.735217667640524	0.894519699887161	COLGALT1	1
GO:0097472	cyclin-dependent protein kinase activity	1/822	29/18367	0.735217667640524	0.894519699887161	CDK18	1
GO:0032182	ubiquitin-like protein binding	4/822	111/18367	0.737649162538882	0.894519699887161	AMFR/NBR1/STAM2/HSPB1	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/822	58/18367	0.739318048694921	0.894519699887161	CD36/SLC16A7	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	2/822	58/18367	0.739318048694921	0.894519699887161	DTWD1/GSTM3	2
GO:0046943	carboxylic acid transmembrane transporter activity	6/822	163/18367	0.742691745935968	0.894519699887161	SLC16A10/CD36/SLC16A7/SERINC3/SLC38A2/SERINC5	6
GO:0008168	methyltransferase activity	8/822	214/18367	0.746805853758177	0.894519699887161	NNMT/INMT/PRDM6/TRMT44/KMT2A/ASH1L/RNMT/ICMT	8
GO:0005184	neuropeptide hormone activity	1/822	30/18367	0.74708652341539	0.894519699887161	SPX	1
GO:0005343	organic acid:sodium symporter activity	1/822	30/18367	0.74708652341539	0.894519699887161	SLC38A2	1
GO:0016417	S-acyltransferase activity	1/822	30/18367	0.74708652341539	0.894519699887161	ZDHHC21	1
GO:0022829	wide pore channel activity	1/822	30/18367	0.74708652341539	0.894519699887161	GJA1	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/822	30/18367	0.74708652341539	0.894519699887161	HSD17B2	1
GO:0046966	thyroid hormone receptor binding	1/822	30/18367	0.74708652341539	0.894519699887161	MED13	1
GO:0016279	protein-lysine N-methyltransferase activity	2/822	59/18367	0.747870322011049	0.894519699887161	KMT2A/ASH1L	2
GO:0005342	organic acid transmembrane transporter activity	6/822	164/18367	0.747929749068332	0.894519699887161	SLC16A10/CD36/SLC16A7/SERINC3/SLC38A2/SERINC5	6
GO:0008234	cysteine-type peptidase activity	7/822	190/18367	0.751651180268967	0.897686266721223	CTSK/SCRN1/CTSO/CAPN2/USP11/USP47/USP9X	7
GO:0016278	lysine N-methyltransferase activity	2/822	60/18367	0.756180394854082	0.8980771166836	KMT2A/ASH1L	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/822	60/18367	0.756180394854082	0.8980771166836	BDH2/ZADH2	2
GO:0045182	translation regulator activity	5/822	140/18367	0.756291958576938	0.8980771166836	EIF4EBP1/EIF4G3/EIF4A2/PURA/EIF4EBP2	5
GO:0008157	protein phosphatase 1 binding	1/822	31/18367	0.758423976529451	0.8980771166836	FER	1
GO:0042910	xenobiotic transmembrane transporter activity	1/822	31/18367	0.758423976529451	0.8980771166836	ABCA8	1
GO:0140318	protein transporter activity	1/822	31/18367	0.758423976529451	0.8980771166836	SEC61A1	1
GO:0051117	ATPase binding	3/822	89/18367	0.766799757486459	0.903224957691075	ATP1B1/TMEM106B/PKD2	3
GO:0001222	transcription corepressor binding	1/822	32/18367	0.769253791717758	0.903224957691075	USP11	1
GO:0001223	transcription coactivator binding	1/822	32/18367	0.769253791717758	0.903224957691075	EPAS1	1
GO:0008175	tRNA methyltransferase activity	1/822	32/18367	0.769253791717758	0.903224957691075	TRMT44	1
GO:0008378	galactosyltransferase activity	1/822	32/18367	0.769253791717758	0.903224957691075	COLGALT1	1
GO:0031624	ubiquitin conjugating enzyme binding	1/822	32/18367	0.769253791717758	0.903224957691075	ZMYM2	1
GO:1990841	promoter-specific chromatin binding	2/822	62/18367	0.772092095286051	0.90528610330875	NDN/KLF4	2
GO:0015293	symporter activity	5/822	144/18367	0.777531463147772	0.910386979259857	SLC22A3/SLC2A10/SLC16A7/SLC5A3/SLC38A2	5
GO:0004623	phospholipase A2 activity	1/822	33/18367	0.779598672176335	0.911530755160022	PLA2G2A	1
GO:0016758	hexosyltransferase activity	7/822	197/18367	0.783678398571239	0.915021146935133	CSGALNACT1/CSGALNACT2/EXT1/COLGALT1/GALNT1/CHPF2/DPY19L4	7
GO:0005262	calcium channel activity	4/822	119/18367	0.785173936679292	0.915153963027919	PKD1/PKD2/SEC61A1/TPCN1	4
GO:0051213	dioxygenase activity	3/822	92/18367	0.785981513701012	0.915153963027919	P4HA2/PLOD2/EGLN3	3
GO:0016229	steroid dehydrogenase activity	1/822	34/18367	0.789480306924401	0.915402963368654	HSD17B2	1
GO:0045505	dynein intermediate chain binding	1/822	34/18367	0.789480306924401	0.915402963368654	DYNLT3	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/822	34/18367	0.789480306924401	0.915402963368654	PTEN	1
GO:0016741	transferase activity, transferring one-carbon groups	8/822	225/18367	0.793832487843862	0.918395619336424	NNMT/INMT/PRDM6/TRMT44/KMT2A/ASH1L/RNMT/ICMT	8
GO:0008173	RNA methyltransferase activity	2/822	65/18367	0.794258412416548	0.918395619336424	TRMT44/RNMT	2
GO:0042887	amide transmembrane transporter activity	1/822	35/18367	0.798919416055921	0.921679561442226	GJA1	1
GO:0003730	mRNA 3'-UTR binding	7/822	201/18367	0.800545016528126	0.921679561442226	PABPC4L/RBMS3/RBMS1/CELF2/ZFP36L2/ZFP36L1/PUM2	7
GO:0043022	ribosome binding	2/822	66/18367	0.801212469591802	0.921679561442226	SEC61A1/SBDS	2
GO:0046982	protein heterodimerization activity	12/822	328/18367	0.801508422450357	0.921679561442226	TCF4/TPM2/ATP1B1/EXT1/EPAS1/PIK3R1/ITGB1/TPM4/ZHX1/TPM1/TCF12/SOS1	12
GO:0005484	SNAP receptor activity	1/822	36/18367	0.807935793974425	0.926546177330761	STX2	1
GO:0097110	scaffold protein binding	2/822	67/18367	0.80795713310302	0.926546177330761	IL6ST/VIM	2
GO:0015103	inorganic anion transmembrane transporter activity	5/822	152/18367	0.815698906959143	0.931288432722992	SLC22A3/FXYD1/CLCN5/APOL1/ANO10	5
GO:0016409	palmitoyltransferase activity	1/822	37/18367	0.816548350700901	0.931288432722992	ZDHHC21	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/822	37/18367	0.816548350700901	0.931288432722992	ALDH9A1	1
GO:0043531	ADP binding	1/822	37/18367	0.816548350700901	0.931288432722992	CYB5R3	1
GO:0004521	endoribonuclease activity	2/822	69/18367	0.82083741681437	0.934904741766775	RPP25/AGO3	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/822	38/18367	0.8247751513405	0.935531032898474	ZMYM2	1
GO:0140303	intramembrane lipid transporter activity	1/822	38/18367	0.8247751513405	0.935531032898474	PLSCR4	1
GO:0042826	histone deacetylase binding	4/822	127/18367	0.825579191336853	0.935531032898474	TCF21/NCOR2/KLF4/MIER1	4
GO:0001098	basal transcription machinery binding	2/822	70/18367	0.826982575732024	0.935531032898474	TCF4/RTF1	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/822	70/18367	0.826982575732024	0.935531032898474	TCF4/RTF1	2
GO:0140678	molecular function inhibitor activity	4/822	128/18367	0.830158444360075	0.93785467497976	CAMK2D/TXNIP/WNK1/PURA	4
GO:0005504	fatty acid binding	1/822	39/18367	0.832633453790067	0.938457773225672	PTGDS	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/822	71/18367	0.832937401595034	0.938457773225672	GLS/MIER1	2
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	2/822	72/18367	0.838706597134668	0.943686023155562	CYBRD1/COX7A1	2
GO:0042287	MHC protein binding	1/822	40/18367	0.840139744764782	0.94402799277333	CD81	1
GO:0106306	protein serine phosphatase activity	2/822	73/18367	0.844294825911073	0.946153451020988	PTEN/PPM1K	2
GO:0106307	protein threonine phosphatase activity	2/822	73/18367	0.844294825911073	0.946153451020988	PTEN/PPM1K	2
GO:0030331	estrogen receptor binding	1/822	41/18367	0.847309774218776	0.94826100568527	NCOA1	1
GO:0019894	kinesin binding	1/822	42/18367	0.854158588231226	0.953373270709353	CLSTN1	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/822	42/18367	0.854158588231226	0.953373270709353	REV3L	1
GO:0005246	calcium channel regulator activity	1/822	43/18367	0.860700560426257	0.959108136770384	PRKG1	1
GO:0003724	RNA helicase activity	2/822	77/18367	0.864929659252959	0.959108136770384	DDX17/EIF4A2	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/822	44/18367	0.866949421991942	0.959108136770384	DSTYK	1
GO:0008375	acetylglucosaminyltransferase activity	1/822	44/18367	0.866949421991942	0.959108136770384	EXT1	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/822	44/18367	0.866949421991942	0.959108136770384	ALDH9A1	1
GO:0051879	Hsp90 protein binding	1/822	44/18367	0.866949421991942	0.959108136770384	NR3C1	1
GO:0090079	translation regulator activity, nucleic acid binding	3/822	108/18367	0.86732745382585	0.959108136770384	EIF4G3/EIF4A2/PURA	3
GO:0000287	magnesium ion binding	7/822	221/18367	0.870149602803149	0.959766425583781	GNAI1/PGM3/CDC42BPA/RAP2A/MAP3K8/ABL1/WNK1	7
GO:0046873	metal ion transmembrane transporter activity	15/822	430/18367	0.871067899459244	0.959766425583781	SLC22A3/KCNMA1/SLC39A13/ATP1B1/SLC9A9/PKD1/SLC39A6/SLC40A1/PKD2/SEC61A1/SLC5A3/SLC38A2/TPCN1/SLC39A4/SLC8A1	15
GO:0042626	ATPase-coupled transmembrane transporter activity	3/822	109/18367	0.871366886385275	0.959766425583781	ABCA8/ATP1B1/ABCA5	3
GO:0140223	general transcription initiation factor activity	1/822	45/18367	0.872918290360802	0.960210119396882	SNAPC3	1
GO:0008186	ATP-dependent activity, acting on RNA	2/822	79/18367	0.874278753261982	0.960442887946146	DDX17/EIF4A2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	5/822	170/18367	0.882430381565837	0.968125720458058	P4HA2/PLOD2/EGLN3/CYP20A1/FADS3	5
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/822	47/18367	0.884065611647991	0.96864856007565	ATP1B1	1
GO:0004843	thiol-dependent deubiquitinase	3/822	113/18367	0.886456598928208	0.969280750964484	USP11/USP47/USP9X	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/822	48/18367	0.889267471212694	0.969280750964484	GCLM	1
GO:0101005	deubiquitinase activity	3/822	114/18367	0.889973336784616	0.969280750964484	USP11/USP47/USP9X	3
GO:0003924	GTPase activity	11/822	337/18367	0.893094704447926	0.969280750964484	GNG11/RND3/RRAS/RAB23/ARHGAP5/GNAI1/RAP2A/RHOQ/RAP2B/SAR1A/ATL3	11
GO:0008009	chemokine activity	1/822	49/18367	0.894236199782112	0.969280750964484	CXCL14	1
GO:0016763	pentosyltransferase activity	1/822	49/18367	0.894236199782112	0.969280750964484	GXYLT2	1
GO:0008135	translation factor activity, RNA binding	2/822	84/18367	0.895101132503574	0.969280750964484	EIF4G3/EIF4A2	2
GO:0050660	flavin adenine dinucleotide binding	2/822	85/18367	0.898860816025514	0.969280750964484	STEAP4/CYB5R3	2
GO:0000993	RNA polymerase II complex binding	1/822	50/18367	0.898982233398178	0.969280750964484	RTF1	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/822	50/18367	0.898982233398178	0.969280750964484	SIDT2	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/822	50/18367	0.898982233398178	0.969280750964484	IL1R1	1
GO:0008528	G protein-coupled peptide receptor activity	4/822	147/18367	0.899715146828277	0.969280750964484	VIPR2/EDNRB/CMKLR1/RAMP1	4
GO:0052689	carboxylic ester hydrolase activity	4/822	147/18367	0.899715146828277	0.969280750964484	ENPP2/PLA2G2A/CES1/H6PD	4
GO:0016597	amino acid binding	1/822	52/18367	0.90784564766666	0.971627632136993	DDAH2	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/822	52/18367	0.90784564766666	0.971627632136993	RNF169	1
GO:0005506	iron ion binding	4/822	151/18367	0.910669048137164	0.971627632136993	P4HA2/PLOD2/EGLN3/CYP20A1	4
GO:0050661	NADP binding	1/822	53/18367	0.911981649720605	0.971627632136993	H6PD	1
GO:0015399	primary active transmembrane transporter activity	5/822	181/18367	0.912085258694089	0.971627632136993	ABCA8/CYBRD1/ATP1B1/COX7A1/ABCA5	5
GO:0001653	peptide receptor activity	4/822	153/18367	0.915736659995178	0.971627632136993	VIPR2/EDNRB/CMKLR1/RAMP1	4
GO:0005249	voltage-gated potassium channel activity	2/822	90/18367	0.915844191180204	0.971627632136993	KCNMA1/PKD2	2
GO:0005544	calcium-dependent phospholipid binding	1/822	54/18367	0.915932238555904	0.971627632136993	ESYT2	1
GO:0030170	pyridoxal phosphate binding	1/822	55/18367	0.919705716408088	0.971627632136993	OAT	1
GO:0140101	catalytic activity, acting on a tRNA	3/822	124/18367	0.920115221704846	0.971627632136993	RPP25/TRMT44/DTWD1	3
GO:0016757	glycosyltransferase activity	8/822	270/18367	0.92045659775287	0.971627632136993	GXYLT2/CSGALNACT1/CSGALNACT2/EXT1/COLGALT1/GALNT1/CHPF2/DPY19L4	8
GO:0015079	potassium ion transmembrane transporter activity	4/822	155/18367	0.92054608273283	0.971627632136993	KCNMA1/ATP1B1/SLC9A9/PKD2	4
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/822	125/18367	0.92267262661096	0.971627632136993	GLS/DDAH2/MIER1	3
GO:0019783	ubiquitin-like protein-specific protease activity	3/822	125/18367	0.92267262661096	0.971627632136993	USP11/USP47/USP9X	3
GO:0070279	vitamin B6 binding	1/822	56/18367	0.923310014197109	0.971627632136993	OAT	1
GO:0016887	ATP hydrolysis activity	8/822	272/18367	0.924038832339281	0.971627632136993	HSPA2/MYO1E/CHD9/DDX17/EIF4A2/ATRX/RECQL/NAV2	8
GO:0008242	omega peptidase activity	3/822	126/18367	0.925154930117609	0.971627632136993	USP11/USP47/USP9X	3
GO:0009055	electron transfer activity	3/822	126/18367	0.925154930117609	0.971627632136993	STEAP4/P4HA2/COX7A1	3
GO:0004536	deoxyribonuclease activity	1/822	57/18367	0.926752708114972	0.971627632136993	PLD3	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/822	57/18367	0.926752708114972	0.971627632136993	SELENBP1	1
GO:0043175	RNA polymerase core enzyme binding	1/822	57/18367	0.926752708114972	0.971627632136993	RTF1	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	2/822	94/18367	0.92746273976713	0.971627632136993	MAN1A1/FUCA2	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/822	59/18367	0.933181909843255	0.975175095786202	PLD3	1
GO:0036002	pre-mRNA binding	1/822	59/18367	0.933181909843255	0.975175095786202	CELF2	1
GO:0004722	protein serine/threonine phosphatase activity	2/822	98/18367	0.93755495954133	0.978521780495072	PTEN/PPM1K	2
GO:0061659	ubiquitin-like protein ligase activity	9/822	316/18367	0.947543362398097	0.987713529881308	PDZRN3/PIAS2/LTN1/RNF145/UBR4/AMFR/SHPRH/HECTD1/RNF170	9
GO:0019787	ubiquitin-like protein transferase activity	14/822	458/18367	0.952085754353908	0.989115357348004	PDZRN3/PIAS2/LTN1/TTC3/LMO7/RNF145/UBR4/AMFR/SHPRH/KLHL9/MIB1/PJA2/HECTD1/RNF170	14
GO:0004842	ubiquitin-protein transferase activity	13/822	433/18367	0.95416429822752	0.989115357348004	PDZRN3/LTN1/TTC3/LMO7/RNF145/UBR4/AMFR/SHPRH/KLHL9/MIB1/PJA2/HECTD1/RNF170	13
GO:0019843	rRNA binding	1/822	68/18367	0.955812438712665	0.989115357348004	SBDS	1
GO:0051536	iron-sulfur cluster binding	1/822	68/18367	0.955812438712665	0.989115357348004	REV3L	1
GO:0051540	metal cluster binding	1/822	68/18367	0.955812438712665	0.989115357348004	REV3L	1
GO:0022843	voltage-gated cation channel activity	3/822	143/18367	0.957567564273554	0.989115357348004	KCNMA1/PKD2/TPCN1	3
GO:0016798	hydrolase activity, acting on glycosyl bonds	3/822	144/18367	0.958989450339512	0.989115357348004	IL1R1/MAN1A1/FUCA2	3
GO:0004857	enzyme inhibitor activity	1/822	70/18367	0.95969323202374	0.989115357348004	TXNIP	1
GO:0004518	nuclease activity	5/822	210/18367	0.961113007316647	0.989115357348004	ENPP1/ENPP2/RPP25/AGO3/PLD3	5
GO:0031491	nucleosome binding	1/822	71/18367	0.961504029601293	0.989115357348004	RNF169	1
GO:0099094	ligand-gated cation channel activity	2/822	113/18367	0.964742614575624	0.989115357348004	PKD2/TPCN1	2
GO:0140104	molecular carrier activity	1/822	73/18367	0.964885497917425	0.989115357348004	CLU	1
GO:0061630	ubiquitin protein ligase activity	8/822	304/18367	0.965004182899077	0.989115357348004	PDZRN3/LTN1/RNF145/UBR4/AMFR/SHPRH/HECTD1/RNF170	8
GO:0043021	ribonucleoprotein complex binding	3/822	149/18367	0.965452310521497	0.989115357348004	LTN1/SEC61A1/SBDS	3
GO:0004540	ribonuclease activity	2/822	116/18367	0.968603700104377	0.991129367548665	RPP25/AGO3	2
GO:0034987	immunoglobulin receptor binding	1/822	79/18367	0.97335145905257	0.994371257304099	FLNA	1
GO:0005267	potassium channel activity	2/822	121/18367	0.974150789153179	0.994371257304099	KCNMA1/PKD2	2
GO:0004519	endonuclease activity	2/822	129/18367	0.981111421274821	0.996655845406934	RPP25/AGO3	2
GO:0031072	heat shock protein binding	2/822	129/18367	0.981111421274821	0.996655845406934	HSPA2/NR3C1	2
GO:0005244	voltage-gated ion channel activity	4/822	201/18367	0.981157608576444	0.996655845406934	KCNMA1/CLCN5/PKD2/TPCN1	4
GO:0022832	voltage-gated channel activity	4/822	201/18367	0.981157608576444	0.996655845406934	KCNMA1/CLCN5/PKD2/TPCN1	4
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/822	88/18367	0.982385173361482	0.996691753556067	CYB5R3	1
GO:0005216	ion channel activity	11/822	432/18367	0.987064015347967	0.997470155835134	FXYD1/KCNMA1/CLCN5/PIEZO1/PKD1/APOL1/PKD2/SEC61A1/ANO10/TMEM120A/TPCN1	11
GO:0015276	ligand-gated ion channel activity	2/822	143/18367	0.989168115085764	0.997470155835134	PKD2/TPCN1	2
GO:0022834	ligand-gated channel activity	2/822	143/18367	0.989168115085764	0.997470155835134	PKD2/TPCN1	2
GO:0004497	monooxygenase activity	1/822	102/18367	0.990752655812392	0.997470155835134	CYP20A1	1
GO:0015267	channel activity	12/822	480/18367	0.991812826143052	0.997470155835134	FXYD1/KCNMA1/GJA1/CLCN5/PIEZO1/PKD1/APOL1/PKD2/SEC61A1/ANO10/TMEM120A/TPCN1	12
GO:0022803	passive transmembrane transporter activity	12/822	481/18367	0.992014203961606	0.997470155835134	FXYD1/KCNMA1/GJA1/CLCN5/PIEZO1/PKD1/APOL1/PKD2/SEC61A1/ANO10/TMEM120A/TPCN1	12
GO:0016829	lyase activity	3/822	196/18367	0.993594510039922	0.997470155835134	GUCY1A2/ADCY3/GLO1	3
GO:0005261	cation channel activity	7/822	335/18367	0.993639878818384	0.997470155835134	KCNMA1/PIEZO1/PKD1/PKD2/SEC61A1/ANO10/TPCN1	7
GO:0030594	neurotransmitter receptor activity	1/822	111/18367	0.993890717476874	0.997470155835134	TSPO	1
GO:0022836	gated channel activity	6/822	340/18367	0.998099917572076	0.999494270470409	KCNMA1/CLCN5/PIEZO1/PKD2/ANO10/TPCN1	6
GO:0140098	catalytic activity, acting on RNA	7/822	386/18367	0.998682007721406	0.999494270470409	RPP25/TRMT44/DTWD1/AGO3/DDX17/EIF4A2/RNMT	7
GO:0016874	ligase activity	1/822	165/18367	0.999494270470409	0.999494270470409	GCLM	1