ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0030198 extracellular matrix organization 68/803 301/18722 2.19203211717296e-30 6.77614976069345e-27 LUM/COL3A1/EGFL6/COL1A1/COL1A2/COL15A1/PDGFRA/PDPN/COL5A1/AEBP1/MMP2/FBLN2/MFAP4/NID1/MMP23B/CRISPLD2/ADAMTS5/TNXB/FMOD/FBLN5/FAP/ANTXR1/DDR2/ELN/COL11A1/LOXL1/CREB3L1/COL16A1/ADAMTS2/EFEMP2/DPT/EMILIN1/SMOC2/COL8A2/PHLDB1/ADAMTS15/TGFBI/GAS6/NID2/COL5A2/CTSK/FSCN1/ADAMTS1/COL4A1/SLC2A10/COL14A1/COL4A2/LAMC1/FKBP10/MYO1E/CCDC80/LAMB2/EXT1/LRP1/DPP4/COLGALT1/SERPINH1/CRTAP/SULF2/ENG/TNFRSF1A/ITGB1/LAMB1/BMP1/ABL1/LTBP3/FBLN1/P3H4 68 GO:0043062 extracellular structure organization 68/803 302/18722 2.71807050168209e-30 6.77614976069345e-27 LUM/COL3A1/EGFL6/COL1A1/COL1A2/COL15A1/PDGFRA/PDPN/COL5A1/AEBP1/MMP2/FBLN2/MFAP4/NID1/MMP23B/CRISPLD2/ADAMTS5/TNXB/FMOD/FBLN5/FAP/ANTXR1/DDR2/ELN/COL11A1/LOXL1/CREB3L1/COL16A1/ADAMTS2/EFEMP2/DPT/EMILIN1/SMOC2/COL8A2/PHLDB1/ADAMTS15/TGFBI/GAS6/NID2/COL5A2/CTSK/FSCN1/ADAMTS1/COL4A1/SLC2A10/COL14A1/COL4A2/LAMC1/FKBP10/MYO1E/CCDC80/LAMB2/EXT1/LRP1/DPP4/COLGALT1/SERPINH1/CRTAP/SULF2/ENG/TNFRSF1A/ITGB1/LAMB1/BMP1/ABL1/LTBP3/FBLN1/P3H4 68 GO:0045229 external encapsulating structure organization 68/803 304/18722 4.16716106774416e-30 6.92582169459079e-27 LUM/COL3A1/EGFL6/COL1A1/COL1A2/COL15A1/PDGFRA/PDPN/COL5A1/AEBP1/MMP2/FBLN2/MFAP4/NID1/MMP23B/CRISPLD2/ADAMTS5/TNXB/FMOD/FBLN5/FAP/ANTXR1/DDR2/ELN/COL11A1/LOXL1/CREB3L1/COL16A1/ADAMTS2/EFEMP2/DPT/EMILIN1/SMOC2/COL8A2/PHLDB1/ADAMTS15/TGFBI/GAS6/NID2/COL5A2/CTSK/FSCN1/ADAMTS1/COL4A1/SLC2A10/COL14A1/COL4A2/LAMC1/FKBP10/MYO1E/CCDC80/LAMB2/EXT1/LRP1/DPP4/COLGALT1/SERPINH1/CRTAP/SULF2/ENG/TNFRSF1A/ITGB1/LAMB1/BMP1/ABL1/LTBP3/FBLN1/P3H4 68 GO:0031589 cell-substrate adhesion 61/803 363/18722 2.88942350121193e-20 3.60166639426067e-17 COL3A1/EGFL6/COL1A1/APOD/PDPN/FBLN2/NID1/VCAM1/TNXB/FBLN5/ITGBL1/ANTXR1/THY1/LAMC3/VTN/CSF1/COL16A1/EFEMP2/EMILIN1/EPHA3/GAS6/NID2/CD36/ITGA1/THBS1/ANGPT1/PEAK1/MYADM/LAMC1/PLAU/FLNA/LGALS1/CASK/PTEN/RRAS/CCDC80/LAMB2/CD63/PKD1/MDK/LRP1/AXL/PTPRK/PIK3R1/RIN2/ROCK2/SGCE/ITGB1/SORBS3/LAMB1/DLC1/PTPRA/ABL1/FBLN1/JAG1/VCL/EPB41L5/FER/MAP4K4/MACF1/ACTN4 61 GO:0060485 mesenchyme development 52/803 291/18722 1.23452547574697e-18 1.23106880441488e-15 HGF/COL1A1/BMP5/TCF21/PDPN/WNT2/PITX2/HAND2/KITLG/PDGFRB/TBX2/EPHA3/PHLDB1/SNAI2/GATA4/VASN/BMP4/EDNRB/ACTA2/FGFR1/LDLRAD4/BAMBI/SPRY1/FLNA/RDH10/TGFBR3/SEMA3B/PTK7/BNC2/PTEN/EXT1/BASP1/ROBO1/MDK/NRP2/PKD2/S100A4/ROCK2/LRP6/TWIST1/TGFBR2/YAP1/ENG/ZFP36L1/SPRED1/DDX17/BMPR2/SEMA6D/JAG1/RTN4/DAB2/EPB41L5 52 GO:0030199 collagen fibril organization 24/803 61/18722 1.41501471415252e-17 1.17587722746074e-14 LUM/COL3A1/COL1A1/COL1A2/COL5A1/AEBP1/TNXB/FMOD/DDR2/COL11A1/LOXL1/ADAMTS2/EFEMP2/DPT/EMILIN1/COL5A2/COL14A1/FKBP10/EXT1/COLGALT1/SERPINH1/CRTAP/BMP1/P3H4 24 GO:0001503 ossification 57/803 408/18722 2.91233441760996e-15 2.07441420088618e-12 HGF/COL1A1/COL1A2/ENPP1/COL6A1/BMP5/CTHRC1/CDH11/MMP2/MGP/STC1/IGFBP5/DDR2/HAND2/ECM1/COL11A1/CREB3L1/CSF1/RSPO2/SNAI2/BMP4/VCAN/SPARC/MRC2/COL5A2/GPC3/BAMBI/CTSK/OSR2/THRA/IL6ST/TWSG1/IGF2/ACVR2A/IFITM1/PDLIM7/GPNMB/EXT1/SMAD5/MDK/CLEC11A/TWIST1/YAP1/TPM4/RRBP1/BMPR2/BMP1/LTBP3/JAG1/SBDS/SKI/SP3/SLC8A1/SORT1/CLTC/NBR1/CRIM1 57 GO:0042060 wound healing 57/803 422/18722 1.30192762394556e-14 8.11426391624068e-12 DCN/COL3A1/COL1A1/PDGFRA/PDPN/F3/COL5A1/MYL9/FAP/WFDC1/PROS1/VTN/PDGFRB/SMOC2/PRKG1/GATA4/GAS6/CD36/SPARC/SERPINE2/THBS1/PPL/APOE/MYLK/TIMP1/GJA1/PRKCA/PLPP3/IL6ST/PLAU/FLNA/CLDN1/CD9/SERPING1/CASK/FKBP10/PTK7/PTEN/DST/EXT1/TFPI/AXL/TGFBR2/YAP1/ITGB1/RAP2B/NOTCH2/SDC1/CD151/PLAUR/CNN2/PLEC/TPM1/FBLN1/VCL/MACF1/HSPB1 57 GO:0007160 cell-matrix adhesion 40/803 233/18722 5.08614901282166e-14 2.8177265531032e-11 COL3A1/APOD/NID1/VCAM1/TNXB/FBLN5/ITGBL1/THY1/VTN/CSF1/COL16A1/EFEMP2/EMILIN1/EPHA3/NID2/CD36/ITGA1/THBS1/PEAK1/PLAU/CASK/PTEN/RRAS/CD63/PKD1/LRP1/PTPRK/PIK3R1/RIN2/ROCK2/SGCE/ITGB1/DLC1/PTPRA/ABL1/JAG1/VCL/EPB41L5/MAP4K4/MACF1 40 GO:0071559 response to transforming growth factor beta 42/803 256/18722 5.92264592354216e-14 2.95303125747812e-11 COL3A1/COL1A1/COL1A2/WNT2/FMOD/LTBP4/PDE3A/DKK3/EMILIN1/SOX5/VASN/LTBP2/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/COL4A2/SPRY1/TWSG1/CLDN1/TGFBR3/HTRA1/SMAD5/NR3C1/PTPRK/ROCK2/TGFBR2/ZFP36L2/ENG/ZFP36L1/SPRED1/FBN1/LTBP3/SKIL/DAB2/EPB41L5/SKI/STAT3/ZMIZ1/ZFHX3/USP9X 42 GO:0048762 mesenchymal cell differentiation 40/803 236/18722 7.87569632937023e-14 3.56983835438545e-11 HGF/COL1A1/BMP5/TCF21/PDPN/WNT2/PITX2/HAND2/KITLG/EPHA3/PHLDB1/SNAI2/VASN/BMP4/EDNRB/FGFR1/LDLRAD4/BAMBI/SPRY1/FLNA/RDH10/TGFBR3/SEMA3B/PTEN/EXT1/MDK/NRP2/S100A4/ROCK2/LRP6/TWIST1/TGFBR2/ENG/SPRED1/DDX17/SEMA6D/JAG1/RTN4/DAB2/EPB41L5 40 GO:0010810 regulation of cell-substrate adhesion 38/803 221/18722 2.08625745627946e-13 8.66839973084118e-11 EGFL6/COL1A1/APOD/PDPN/FBLN2/NID1/THY1/CSF1/COL16A1/EFEMP2/EMILIN1/EPHA3/CD36/THBS1/PEAK1/MYADM/PLAU/FLNA/LGALS1/CASK/PTEN/RRAS/CCDC80/MDK/LRP1/PIK3R1/RIN2/ROCK2/DLC1/PTPRA/ABL1/FBLN1/JAG1/VCL/EPB41L5/MAP4K4/MACF1/ACTN4 38 GO:0071560 cellular response to transforming growth factor beta stimulus 40/803 250/18722 5.48807728845911e-13 2.10488872001978e-10 COL3A1/COL1A1/COL1A2/WNT2/FMOD/LTBP4/PDE3A/DKK3/EMILIN1/SOX5/VASN/LTBP2/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/COL4A2/SPRY1/TWSG1/CLDN1/TGFBR3/HTRA1/SMAD5/NR3C1/PTPRK/TGFBR2/ZFP36L2/ENG/ZFP36L1/SPRED1/FBN1/LTBP3/SKIL/DAB2/EPB41L5/SKI/STAT3/ZMIZ1/USP9X 40 GO:0001667 ameboidal-type cell migration 58/803 475/18722 6.18816657277762e-13 2.20387132370494e-10 DCN/FGF7/ENPP2/STC1/PITX2/SLIT2/FAP/DDR2/HAND2/ADGRA2/KITLG/SMOC2/MCC/AKAP12/BMP4/SPARC/GPC3/THBS1/EDNRB/KANK2/APOE/FGFR1/ANGPT1/TIMP1/GJA1/PRKCA/ZEB2/PLPP3/EFNB2/SERPINF1/SEMA3B/PTEN/RRAS/ROBO1/NRP2/FSTL1/DPP4/RIN2/ROCK2/TWIST1/TGFBR2/ITGB1/SPRED1/PTPRG/KLF4/BMPR2/ABL1/SEMA6D/PLEC/RTN4/ARID5B/EPB41L5/FER/MAP4K4/SLC8A1/MACF1/HSPB1/AMOTL2 58 GO:0090287 regulation of cellular response to growth factor stimulus 44/803 304/18722 1.35093390924991e-12 4.49050431434669e-10 DCN/SLIT2/LTBP4/ADGRA2/VTN/FST/CREB3L1/DKK3/EMILIN1/SMOC2/HOXA13/GATA4/VASN/BMP4/GPC3/THBS1/FGFR1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TWSG1/CASK/TGFBR3/HTRA1/ROBO1/CD63/FSTL1/SULF2/ENG/SPRED1/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/DSTYK/SKIL/DAB2/NPTN/SKI/MYO1C/CRIM1 44 GO:0051271 negative regulation of cellular component movement 49/803 367/18722 1.53311119708793e-12 4.77755776792525e-10 DCN/IGFBP3/COL3A1/APOD/BMP5/STC1/SLIT2/IGFBP5/THY1/EMILIN1/PRKG1/PODN/MCC/DPYSL3/THBS1/APOE/LDLRAD4/TIMP1/GJA1/BIN1/CD9/IFITM1/TGFBR3/SERPINF1/PTEN/RRAS/ROBO1/LRP1/DPP4/PTPRK/PLCB1/RAP2A/ENG/BST2/SPRED1/RAP2B/PTPRG/DLC1/KLF4/CNN2/SEMA6D/TPM1/FBLN1/JAG1/VCL/FOXO3/STAT3/WASL/CERS2 49 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 48/803 355/18722 1.63525889956805e-12 4.7961181607331e-10 COL3A1/COL1A2/BMP5/FMOD/LTBP4/FST/DKK3/EMILIN1/HOXA13/GDF6/GATA4/VASN/BMP4/LTBP2/GPC3/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TWSG1/VIM/SPTBN1/ACVR2A/TGFBR3/HTRA1/EXT1/SMAD5/LRP1/FSTL1/PTPRK/TGFBR2/ENG/SPRED1/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/LTBP3/SKIL/DAB2/SKI/STAT3/ZMIZ1/CRIM1/USP9X 48 GO:0002064 epithelial cell development 36/803 220/18722 4.09235919498667e-12 1.13358349701131e-09 BMP5/COL15A1/STC1/HOXA13/BMP4/ACTA2/HEG1/IL6ST/MYADM/FLNA/CLDN1/PALLD/VIM/MYO1E/LAMB2/ROCK2/PLCB1/YAP1/TNFRSF1A/ABI2/NOTCH2/SDC1/SIDT2/PLEC/FOSL2/JAG1/ATRX/VCL/FRS2/FNDC3A/EPB41L5/MSN/ZDHHC21/TJP1/GSTM3/CLOCK 36 GO:0001837 epithelial to mesenchymal transition 30/803 157/18722 4.53213019675478e-12 1.18932637689575e-09 HGF/COL1A1/BMP5/PDPN/WNT2/EPHA3/PHLDB1/SNAI2/VASN/BMP4/FGFR1/LDLRAD4/BAMBI/SPRY1/FLNA/TGFBR3/PTEN/MDK/S100A4/ROCK2/LRP6/TWIST1/TGFBR2/ENG/SPRED1/DDX17/JAG1/RTN4/DAB2/EPB41L5 30 GO:0061448 connective tissue development 38/803 252/18722 1.33682945919663e-11 3.3327158417772e-09 LUM/COL1A1/BMP5/COL5A1/MGP/STC1/CYTL1/HAND2/ECM1/COL11A1/CSF1/PDGFRB/SOX5/RSPO2/GDF6/SNAI2/PITX1/TGFBI/BMP4/MAF/ACTA2/CTSK/TIMP1/OSR2/THRA/SLC39A13/NFIB/EXT1/SMAD5/PKD1/MDK/SERPINH1/TGFBR2/SULF2/BMPR2/BMP1/LTBP3/ARID5B 38 GO:0030336 negative regulation of cell migration 45/803 344/18722 2.57041453013035e-11 6.10289849868091e-09 DCN/IGFBP3/COL3A1/APOD/BMP5/STC1/SLIT2/IGFBP5/THY1/EMILIN1/PRKG1/PODN/MCC/DPYSL3/THBS1/APOE/LDLRAD4/TIMP1/GJA1/IFITM1/SERPINF1/PTEN/RRAS/ROBO1/LRP1/DPP4/PTPRK/PLCB1/RAP2A/ENG/BST2/SPRED1/RAP2B/PTPRG/DLC1/KLF4/CNN2/SEMA6D/TPM1/JAG1/VCL/FOXO3/STAT3/WASL/CERS2 45 GO:0051216 cartilage development 32/803 190/18722 2.95145610565966e-11 6.68907279219048e-09 LUM/COL1A1/BMP5/MGP/STC1/CYTL1/HAND2/ECM1/COL11A1/SOX5/RSPO2/GDF6/SNAI2/PITX1/TGFBI/BMP4/MAF/CTSK/TIMP1/OSR2/THRA/NFIB/EXT1/SMAD5/PKD1/MDK/SERPINH1/TGFBR2/SULF2/BMPR2/BMP1/LTBP3 32 GO:2000146 negative regulation of cell motility 46/803 359/18722 3.15432433703984e-11 6.83802658455681e-09 DCN/IGFBP3/COL3A1/APOD/BMP5/STC1/SLIT2/IGFBP5/THY1/EMILIN1/PRKG1/PODN/MCC/DPYSL3/THBS1/APOE/LDLRAD4/TIMP1/GJA1/IFITM1/SERPINF1/PTEN/RRAS/ROBO1/LRP1/DPP4/PTPRK/PLCB1/RAP2A/ENG/BST2/SPRED1/RAP2B/PTPRG/DLC1/KLF4/CNN2/SEMA6D/TPM1/FBLN1/JAG1/VCL/FOXO3/STAT3/WASL/CERS2 46 GO:0050673 epithelial cell proliferation 51/803 437/18722 8.50830727842756e-11 1.76760083709332e-08 HGF/BMP5/FGF7/F3/WNT2/IGFBP5/FAP/WFDC1/ECM1/FST/COL8A2/MCC/SNAI2/BMP4/SPARC/GPC3/THBS1/EDNRB/APOE/FGFR1/GJA1/OSR2/PRKCA/LAMC1/CLDN1/IGF2/ACVR2A/CASK/TGFBR3/SERPINF1/HTRA1/NFIB/PTEN/ROBO1/MDK/NRP2/B2M/PTPRK/TWIST1/YAP1/SULF2/NUPR1/ZFP36L1/NOTCH2/LAMB1/SIDT2/BMPR2/RTN4/PURA/FRS2/STAT3 51 GO:0003007 heart morphogenesis 36/803 246/18722 1.10552927340297e-10 2.20486758287489e-08 BMP5/WNT2/COL5A1/PITX2/SLIT2/HAND2/ELN/COL11A1/SLIT3/TBX2/GATA6/SNAI2/GATA4/BMP4/HEG1/ADAMTS1/SPRY1/FLNA/TGFBR3/EXT1/ROBO1/NRP2/PKD2/TWIST1/TGFBR2/YAP1/ENG/NOTCH2/DLC1/BMPR2/TPM1/JAG1/RTN4/ZMIZ1/MIB1/SOS1 36 GO:0001952 regulation of cell-matrix adhesion 25/803 128/18722 1.68645812609603e-10 3.03493826757851e-08 APOD/THY1/CSF1/COL16A1/EFEMP2/EPHA3/CD36/THBS1/PEAK1/PLAU/CASK/PTEN/RRAS/LRP1/PIK3R1/RIN2/ROCK2/DLC1/PTPRA/ABL1/JAG1/VCL/EPB41L5/MAP4K4/MACF1 25 GO:0060541 respiratory system development 32/803 203/18722 1.74019871145024e-10 3.03493826757851e-08 TCF21/PDGFRA/FGF7/PDPN/WNT2/CRISPLD2/IGFBP5/MSC/PDGFRB/ADAMTS2/GATA6/RSPO2/BMP4/SPARC/GPC3/HEG1/THRA/SPRY1/RDH10/PTK7/NFIB/EXT1/BASP1/PKD1/EPAS1/EIF4EBP1/TGFBR2/YAP1/BMPR2/LTBP3/SKI/SP3 32 GO:0040013 negative regulation of locomotion 47/803 391/18722 1.75348111750505e-10 3.03493826757851e-08 DCN/IGFBP3/COL3A1/APOD/BMP5/STC1/SLIT2/IGFBP5/THY1/EMILIN1/PRKG1/PODN/MCC/DPYSL3/THBS1/APOE/LDLRAD4/TIMP1/GJA1/IFITM1/SERPINF1/SEMA3B/PTEN/RRAS/ROBO1/LRP1/DPP4/PTPRK/PLCB1/RAP2A/ENG/BST2/SPRED1/RAP2B/PTPRG/DLC1/KLF4/CNN2/SEMA6D/TPM1/FBLN1/JAG1/VCL/FOXO3/STAT3/WASL/CERS2 47 GO:0001655 urogenital system development 43/803 338/18722 1.76520677416319e-10 3.03493826757851e-08 DCN/TCF21/PDGFRA/NID1/SLIT2/PDGFRB/HOXA13/GDF6/BICC1/BMP4/PROM1/GPC3/ACTA2/KANK2/ANGPT1/NFIA/OSR2/ADAMTS1/COL4A1/SPRY1/MYO1E/RDH10/GLIS2/SERPINF1/PTK7/PTEN/LAMB2/EXT1/BASP1/SMAD5/PKD1/PKD2/SEC61A1/YAP1/SULF2/NOTCH2/FBN1/SDC1/AP2B1/JAG1/ARID5B/FRS2/CEP290 43 GO:0060840 artery development 22/803 100/18722 1.89400454187333e-10 3.14783554859347e-08 HAND2/LOXL1/PDGFRB/EFEMP2/TBX2/HOXA13/BMP4/APOE/MYLK/SLC2A10/PRICKLE1/FKBP10/ROBO1/MDK/LRP1/PKD2/ENG/BMPR2/AP2B1/JAG1/ZMIZ1/HECTD1 22 GO:0072001 renal system development 40/803 302/18722 2.28017807131127e-10 3.66740898824451e-08 DCN/TCF21/PDGFRA/NID1/SLIT2/PDGFRB/GDF6/BICC1/BMP4/PROM1/GPC3/ACTA2/KANK2/ANGPT1/NFIA/OSR2/ADAMTS1/COL4A1/SPRY1/MYO1E/RDH10/GLIS2/SERPINF1/PTK7/LAMB2/EXT1/BASP1/SMAD5/PKD1/PKD2/SEC61A1/YAP1/SULF2/NOTCH2/FBN1/SDC1/AP2B1/JAG1/ARID5B/CEP290 40 GO:0048608 reproductive structure development 49/803 424/18722 2.83111501615574e-10 4.41123108454766e-08 DCN/BMP5/TCF21/PDGFRA/WNT2/STC1/HSD17B2/SLIT2/RSPO3/FST/SLIT3/PLAC1/KITLG/PDGFRB/GATA6/HOXA13/GATA4/BMP4/SERPINE2/GJA1/ADAMTS1/FLNA/IGF2/ACVR2A/RDH10/SERPINF1/HTRA1/PTEN/BASP1/PKD1/AXL/EPAS1/PKD2/SOCS3/NUPR1/ZFP36L1/NOTCH2/SDC1/BMPR2/ASH1L/ATRX/ARID5B/FRS2/FNDC3A/FOXO3/SP3/HECTD1/BPTF/NCOA1 49 GO:0061458 reproductive system development 49/803 427/18722 3.61389946918374e-10 5.46027356162124e-08 DCN/BMP5/TCF21/PDGFRA/WNT2/STC1/HSD17B2/SLIT2/RSPO3/FST/SLIT3/PLAC1/KITLG/PDGFRB/GATA6/HOXA13/GATA4/BMP4/SERPINE2/GJA1/ADAMTS1/FLNA/IGF2/ACVR2A/RDH10/SERPINF1/HTRA1/PTEN/BASP1/PKD1/AXL/EPAS1/PKD2/SOCS3/NUPR1/ZFP36L1/NOTCH2/SDC1/BMPR2/ASH1L/ATRX/ARID5B/FRS2/FNDC3A/FOXO3/SP3/HECTD1/BPTF/NCOA1 49 GO:0030324 lung development 29/803 177/18722 4.90653625971049e-10 7.19529111497545e-08 TCF21/PDGFRA/FGF7/PDPN/WNT2/CRISPLD2/IGFBP5/PDGFRB/ADAMTS2/GATA6/RSPO2/BMP4/SPARC/GPC3/HEG1/THRA/SPRY1/RDH10/PTK7/NFIB/EXT1/PKD1/EPAS1/EIF4EBP1/TGFBR2/YAP1/BMPR2/LTBP3/SP3 29 GO:1903034 regulation of response to wounding 28/803 167/18722 5.66282889247286e-10 8.06710424510563e-08 PDGFRA/F3/FAP/WFDC1/PROS1/VTN/SMOC2/PRKG1/CD36/SERPINE2/THBS1/APOE/MYLK/GJA1/PLPP3/PLAU/FLNA/CLDN1/CD9/SERPING1/CASK/PTEN/MDK/LRP1/TFPI/ITGB1/KLF4/CERS2 28 GO:1905314 semi-lunar valve development 14/803 41/18722 7.63345788332293e-10 1.05366304267701e-07 SLIT2/ELN/SLIT3/EMILIN1/SNAI2/GATA4/BMP4/ROBO1/ROCK2/TWIST1/TNFRSF1A/NOTCH2/BMPR2/JAG1 14 GO:1903053 regulation of extracellular matrix organization 15/803 48/18722 7.81899971501189e-10 1.05366304267701e-07 PDPN/AEBP1/FAP/ANTXR1/DDR2/EFEMP2/EMILIN1/PHLDB1/FSCN1/SLC2A10/LRP1/DPP4/COLGALT1/TNFRSF1A/ABL1 15 GO:0030323 respiratory tube development 29/803 181/18722 8.43345717523251e-10 1.0873407438681e-07 TCF21/PDGFRA/FGF7/PDPN/WNT2/CRISPLD2/IGFBP5/PDGFRB/ADAMTS2/GATA6/RSPO2/BMP4/SPARC/GPC3/HEG1/THRA/SPRY1/RDH10/PTK7/NFIB/EXT1/PKD1/EPAS1/EIF4EBP1/TGFBR2/YAP1/BMPR2/LTBP3/SP3 29 GO:0032970 regulation of actin filament-based process 46/803 396/18722 8.50507200378176e-10 1.0873407438681e-07 PDGFRA/PDPN/STC1/SLIT2/SYNPO2/ELN/PDGFRB/EPHA3/PLEKHH2/GATA4/LMOD1/LPAR1/FSCN1/BIN1/CDC42EP5/MYADM/FLNA/SPTBN1/RND3/CFL2/CAMK2D/MDK/LRP1/PIK3R1/ROCK2/BST2/ABI2/EPS8/SORBS3/RHOQ/NOTCH2/DLC1/NCKAP1/CNN2/ABL1/ARHGAP28/TAOK1/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/TJP1/CDC42EP3/AKAP13 46 GO:0003205 cardiac chamber development 27/803 161/18722 1.14312970103229e-09 1.42491117233675e-07 BMP5/WNT2/SLIT2/HAND2/COL11A1/SLIT3/TBX2/GATA6/HOXA13/GATA4/BMP4/HEG1/ADAMTS1/TGFBR3/PTK7/ROBO1/NRP2/TGFBR2/ENG/NOTCH2/BMPR2/AP2B1/TPM1/JAG1/FRS2/HECTD1/SOS1 27 GO:0001822 kidney development 38/803 293/18722 1.18343923826349e-09 1.43917757121506e-07 DCN/TCF21/PDGFRA/NID1/SLIT2/PDGFRB/GDF6/BICC1/BMP4/PROM1/GPC3/ACTA2/KANK2/ANGPT1/OSR2/ADAMTS1/SPRY1/MYO1E/RDH10/GLIS2/SERPINF1/PTK7/LAMB2/EXT1/BASP1/SMAD5/PKD1/PKD2/SEC61A1/YAP1/SULF2/NOTCH2/FBN1/SDC1/AP2B1/JAG1/ARID5B/CEP290 38 GO:0150115 cell-substrate junction organization 21/803 101/18722 1.47387838736402e-09 1.74252431763367e-07 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/LAMC1/PTEN/DST/LRP1/PTPRK/PIK3R1/ROCK2/DLC1/PTPRA/ABL1/PLEC/VCL/EPB41L5/MAP4K4/MACF1 21 GO:0060537 muscle tissue development 46/803 403/18722 1.50277869350678e-09 1.74252431763367e-07 DCN/BMP5/TCF21/PDGFRA/WNT2/SORBS2/IGFBP5/ELN/COL11A1/MSC/PDGFRB/EFEMP2/TBX2/GATA6/PITX1/GATA4/BMP4/HEG1/MYLK/GJA1/EFNB2/IGF2/NEBL/TGFBR3/CFL2/PTEN/SGCB/SMAD5/PDLIM5/PKD2/TWIST1/TGFBR2/YAP1/NUPR1/ENG/ITGB1/NOTCH2/DDX17/PRKAR1A/PLEC/TPM1/FRS2/SKI/PRKAA1/SLC8A1/AKAP13 46 GO:0007179 transforming growth factor beta receptor signaling pathway 30/803 198/18722 1.71188314604001e-09 1.93313254558705e-07 COL3A1/COL1A2/FMOD/LTBP4/DKK3/EMILIN1/VASN/LTBP2/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TWSG1/TGFBR3/HTRA1/SMAD5/PTPRK/TGFBR2/ENG/SPRED1/FBN1/LTBP3/SKIL/DAB2/SKI/STAT3/ZMIZ1/USP9X 30 GO:0060560 developmental growth involved in morphogenesis 33/803 234/18722 1.74470446352621e-09 1.93313254558705e-07 NDN/SLIT2/CSF1/SLIT3/FLRT3/TBX2/MAP1B/BMP4/APOE/SPRY1/RDH10/SEMA3B/ALCAM/PTK7/LAMB2/NRCAM/EXT1/LRP1/NRP2/TGFBR2/YAP1/NIN/ITGB1/BMPR2/ABL1/SEMA6D/RTN4/VCL/EPB41L5/DPYSL2/MACF1/GOLGA4/USP9X 33 GO:0003176 aortic valve development 13/803 37/18722 2.06911496750956e-09 2.24274070173971e-07 SLIT2/ELN/SLIT3/EMILIN1/SNAI2/GATA4/BMP4/ROBO1/ROCK2/TWIST1/TNFRSF1A/BMPR2/JAG1 13 GO:0003279 cardiac septum development 21/803 103/18722 2.14961737897881e-09 2.27959977893815e-07 BMP5/SLIT2/SLIT3/TBX2/GATA6/HOXA13/GATA4/BMP4/HEG1/TGFBR3/PTK7/ROBO1/NRP2/TGFBR2/ENG/NOTCH2/BMPR2/AP2B1/JAG1/FRS2/HECTD1 21 GO:0048732 gland development 48/803 436/18722 2.19456055734118e-09 2.27959977893815e-07 HGF/TCF21/PDGFRA/FGF7/WNT2/PITX2/IGFBP5/HAND2/CSF1/DKK3/TBX2/GATA6/HOXA13/PITX1/BMP4/SERPINE2/PRLR/THRA/TWSG1/CLDN1/IGF2/TGFBR3/SERPINF1/NFIB/PTEN/EXT1/ROBO1/ARHGAP5/PKD1/MDK/NCOR2/PKD2/TSPO/SOCS2/TGFBR2/SULF2/NOTCH2/ABL1/ASH1L/RTN4/IGF2R/ARID5B/FRS2/MSN/SP3/ZDHHC21/RB1CC1/NCOA1 48 GO:0032963 collagen metabolic process 21/803 104/18722 2.58641770465152e-09 2.63181197456989e-07 COL1A1/COL1A2/COL5A1/MMP2/MFAP4/MMP23B/TNXB/FAP/CREB3L1/PDGFRB/ADAMTS2/EMILIN1/BMP4/MRC2/CTSK/VIM/SERPINH1/TRAM2/ENG/ITGB1/P3H4 21 GO:0007044 cell-substrate junction assembly 20/803 95/18722 2.87545731031155e-09 2.86740602984267e-07 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/LAMC1/PTEN/DST/LRP1/PTPRK/ROCK2/DLC1/PTPRA/ABL1/PLEC/VCL/EPB41L5/MAP4K4/MACF1 20 GO:0001654 eye development 43/803 371/18722 3.25933352956563e-09 3.18647783890475e-07 PDGFRA/WNT2/COL5A1/PITX2/THY1/LAMC3/PDGFRB/COL8A2/TBX2/BMP4/PROM1/MFAP2/COL5A2/CRYAB/MAF/OSR2/COL4A1/SPRY1/TWSG1/VIM/MEIS2/RDH10/SERPINF1/LAMB2/TWIST1/TGFBR2/ABI2/SPRED1/NOTCH2/KLF4/FBN1/BMPR2/TUG1/JAG1/SKIL/FRS2/SKI/STAT3/SP3/HIPK1/CEP290/PKNOX1/SOS1 43 GO:0001649 osteoblast differentiation 32/803 229/18722 3.87228226195031e-09 3.71292295347774e-07 HGF/COL1A1/COL6A1/CTHRC1/IGFBP5/DDR2/HAND2/CREB3L1/RSPO2/SNAI2/BMP4/VCAN/MRC2/BAMBI/IL6ST/TWSG1/IGF2/ACVR2A/IFITM1/PDLIM7/GPNMB/SMAD5/TWIST1/YAP1/TPM4/RRBP1/BMPR2/JAG1/SKI/CLTC/NBR1/CRIM1 32 GO:0010975 regulation of neuron projection development 48/803 445/18722 4.28663529657619e-09 4.03267237523187e-07 HGF/BMP5/NR2F1/PMP22/SLIT2/THY1/PTPRD/MAP1B/EPHA3/DPYSL3/CHN1/LPAR1/APOE/SDC2/EFNB2/FLNA/VIM/LGALS1/SERPINF1/SEMA3B/PTK7/PTEN/TMEM106B/ROBO1/PDLIM5/MDK/LRP1/B2M/RAP2A/NIN/ABI2/SCARB2/PTPRG/KLF4/BMPR2/SEMA6D/SKIL/RTN4/SETX/PLXNB2/NPTN/MAP4K4/CCDC88A/VLDLR/CERS2/MACF1/KIDINS220/GOLGA4 48 GO:0150063 visual system development 43/803 375/18722 4.51450806030294e-09 4.16839577567972e-07 PDGFRA/WNT2/COL5A1/PITX2/THY1/LAMC3/PDGFRB/COL8A2/TBX2/BMP4/PROM1/MFAP2/COL5A2/CRYAB/MAF/OSR2/COL4A1/SPRY1/TWSG1/VIM/MEIS2/RDH10/SERPINF1/LAMB2/TWIST1/TGFBR2/ABI2/SPRED1/NOTCH2/KLF4/FBN1/BMPR2/TUG1/JAG1/SKIL/FRS2/SKI/STAT3/SP3/HIPK1/CEP290/PKNOX1/SOS1 43 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 34/803 256/18722 4.80334843877718e-09 4.35445369377146e-07 BMP5/LTBP4/FST/DKK3/EMILIN1/HOXA13/GDF6/GATA4/VASN/BMP4/GPC3/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TWSG1/ACVR2A/TGFBR3/HTRA1/LRP1/FSTL1/ENG/SPRED1/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/SKIL/DAB2/SKI/CRIM1 34 GO:0150116 regulation of cell-substrate junction organization 17/803 71/18722 5.58590685997095e-09 4.97345207210985e-07 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/PTEN/LRP1/PIK3R1/ROCK2/DLC1/PTPRA/ABL1/VCL/EPB41L5/MAP4K4/MACF1 17 GO:0090130 tissue migration 42/803 365/18722 6.16598858649532e-09 5.39361738460801e-07 DCN/FGF7/ENPP2/STC1/SLIT2/FAP/ADGRA2/SMOC2/MCC/BMP4/SPARC/THBS1/ACTA2/KANK2/APOE/FGFR1/ANGPT1/PRKCA/ZEB2/PLPP3/EFNB2/SERPINF1/PTEN/RRAS/ROBO1/NRP2/FSTL1/DPP4/RIN2/ROCK2/TGFBR2/ITGB1/SPRED1/PTPRG/KLF4/BMPR2/ABL1/RTN4/EPB41L5/MAP4K4/MACF1/HSPB1 42 GO:0030509 BMP signaling pathway 25/803 152/18722 7.09394520246828e-09 5.88862714898724e-07 BMP5/FST/HOXA13/GDF6/GATA4/BMP4/GPC3/BAMBI/TWSG1/ACVR2A/TGFBR3/HTRA1/EXT1/SMAD5/FSTL1/ENG/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/SKIL/SKI/CRIM1/USP9X 25 GO:0001701 in utero embryonic development 42/803 367/18722 7.24802609673573e-09 5.88862714898724e-07 BMP5/PDGFRA/WNT2/HSD17B2/HAND2/RSPO3/GATA6/HS3ST6/HEG1/ANGPT1/IGF2/FKBP10/MYO1E/RDH10/PKD1/EPAS1/PKD2/SH3PXD2A/TWIST1/SOCS3/TGFBR2/YAP1/ZFP36L1/ITGB1/CMTM3/NOTCH2/KLF4/CAPN2/N4BP2L2/SKIL/RTN4/SBDS/EPB41L5/ZMIZ1/SP3/SLC35E2B/MIB1/HECTD1/RTF1/KIDINS220/BPTF/NCOA1 42 GO:0048880 sensory system development 43/803 381/18722 7.28379866958913e-09 5.88862714898724e-07 PDGFRA/WNT2/COL5A1/PITX2/THY1/LAMC3/PDGFRB/COL8A2/TBX2/BMP4/PROM1/MFAP2/COL5A2/CRYAB/MAF/OSR2/COL4A1/SPRY1/TWSG1/VIM/MEIS2/RDH10/SERPINF1/LAMB2/TWIST1/TGFBR2/ABI2/SPRED1/NOTCH2/KLF4/FBN1/BMPR2/TUG1/JAG1/SKIL/FRS2/SKI/STAT3/SP3/HIPK1/CEP290/PKNOX1/SOS1 43 GO:0050678 regulation of epithelial cell proliferation 43/803 381/18722 7.28379866958913e-09 5.88862714898724e-07 BMP5/FGF7/F3/WNT2/WFDC1/ECM1/MCC/SNAI2/BMP4/SPARC/GPC3/THBS1/EDNRB/APOE/FGFR1/GJA1/OSR2/PRKCA/LAMC1/CLDN1/IGF2/CASK/TGFBR3/SERPINF1/HTRA1/NFIB/PTEN/ROBO1/MDK/NRP2/B2M/PTPRK/TWIST1/YAP1/SULF2/NUPR1/ZFP36L1/NOTCH2/LAMB1/BMPR2/RTN4/FRS2/STAT3 43 GO:0061564 axon development 49/803 467/18722 7.32240038582449e-09 5.88862714898724e-07 APOD/CDH11/NDN/LAMA2/SLIT2/THY1/SLIT3/NFASC/FLRT3/MAP1B/EPHA3/CHN1/APOE/NEXN/EFNB2/FLNA/PALLD/SEMA3B/ALCAM/NFIB/PTEN/LAMB2/NRCAM/EXT1/ENAH/ROBO1/LRP1/NRP2/S100A6/TSPO/NOTCH3/NIN/ITGB1/NOTCH2/KLF4/BMPR2/ABL1/SEMA6D/SKIL/RTN4/VCL/PLXNB2/NPTN/DPYSL2/CERS2/SOS1/MACF1/GOLGA4/USP9X 49 GO:0003206 cardiac chamber morphogenesis 22/803 121/18722 8.49414595224779e-09 6.72250979649325e-07 BMP5/WNT2/SLIT2/HAND2/COL11A1/SLIT3/TBX2/GATA6/GATA4/BMP4/HEG1/ADAMTS1/TGFBR3/ROBO1/NRP2/TGFBR2/ENG/NOTCH2/BMPR2/TPM1/JAG1/SOS1 22 GO:0071772 response to BMP 26/803 165/18722 8.99542834273042e-09 6.9001854949006e-07 BMP5/FST/GATA6/HOXA13/GDF6/GATA4/BMP4/GPC3/BAMBI/TWSG1/ACVR2A/TGFBR3/HTRA1/EXT1/SMAD5/FSTL1/ENG/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/SKIL/SKI/CRIM1/USP9X 26 GO:0071773 cellular response to BMP stimulus 26/803 165/18722 8.99542834273042e-09 6.9001854949006e-07 BMP5/FST/GATA6/HOXA13/GDF6/GATA4/BMP4/GPC3/BAMBI/TWSG1/ACVR2A/TGFBR3/HTRA1/EXT1/SMAD5/FSTL1/ENG/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/SKIL/SKI/CRIM1/USP9X 26 GO:0010631 epithelial cell migration 41/803 357/18722 9.89979622332479e-09 7.36722148798468e-07 DCN/FGF7/ENPP2/STC1/SLIT2/FAP/ADGRA2/SMOC2/MCC/BMP4/SPARC/THBS1/KANK2/APOE/FGFR1/ANGPT1/PRKCA/ZEB2/PLPP3/EFNB2/SERPINF1/PTEN/RRAS/ROBO1/NRP2/FSTL1/DPP4/RIN2/ROCK2/TGFBR2/ITGB1/SPRED1/PTPRG/KLF4/BMPR2/ABL1/RTN4/EPB41L5/MAP4K4/MACF1/HSPB1 41 GO:0032956 regulation of actin cytoskeleton organization 41/803 357/18722 9.89979622332479e-09 7.36722148798468e-07 PDGFRA/SLIT2/SYNPO2/ELN/PDGFRB/EPHA3/PLEKHH2/LMOD1/LPAR1/FSCN1/BIN1/CDC42EP5/MYADM/FLNA/SPTBN1/RND3/CFL2/MDK/LRP1/PIK3R1/ROCK2/BST2/ABI2/EPS8/SORBS3/RHOQ/NOTCH2/DLC1/NCKAP1/ABL1/ARHGAP28/TAOK1/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/TJP1/CDC42EP3/AKAP13 41 GO:0003170 heart valve development 16/803 65/18722 1.02157163888869e-08 7.49052381102795e-07 SLIT2/ELN/SLIT3/EMILIN1/SNAI2/GATA4/BMP4/ROBO1/ROCK2/TWIST1/TGFBR2/TNFRSF1A/NOTCH2/BMPR2/JAG1/HECTD1 16 GO:0061041 regulation of wound healing 23/803 134/18722 1.22919943202694e-08 8.88230198273382e-07 PDGFRA/F3/FAP/WFDC1/PROS1/VTN/SMOC2/PRKG1/CD36/SERPINE2/THBS1/APOE/MYLK/GJA1/PLPP3/PLAU/CLDN1/CD9/SERPING1/CASK/PTEN/TFPI/ITGB1 23 GO:0090132 epithelium migration 41/803 360/18722 1.26001084677783e-08 8.97039516690685e-07 DCN/FGF7/ENPP2/STC1/SLIT2/FAP/ADGRA2/SMOC2/MCC/BMP4/SPARC/THBS1/KANK2/APOE/FGFR1/ANGPT1/PRKCA/ZEB2/PLPP3/EFNB2/SERPINF1/PTEN/RRAS/ROBO1/NRP2/FSTL1/DPP4/RIN2/ROCK2/TGFBR2/ITGB1/SPRED1/PTPRG/KLF4/BMPR2/ABL1/RTN4/EPB41L5/MAP4K4/MACF1/HSPB1 41 GO:0051893 regulation of focal adhesion assembly 16/803 66/18722 1.29536392301904e-08 8.97039516690685e-07 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/PTEN/LRP1/ROCK2/DLC1/PTPRA/ABL1/VCL/EPB41L5/MAP4K4/MACF1 16 GO:0090109 regulation of cell-substrate junction assembly 16/803 66/18722 1.29536392301904e-08 8.97039516690685e-07 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/PTEN/LRP1/ROCK2/DLC1/PTPRA/ABL1/VCL/EPB41L5/MAP4K4/MACF1 16 GO:0048863 stem cell differentiation 29/803 206/18722 1.75338339383082e-08 1.19758487693705e-06 PDGFRA/PITX2/HAND2/KITLG/SOX5/TBX2/GATA6/SNAI2/GATA4/BMP4/EDNRB/PRICKLE1/RDH10/MLLT3/SEMA3B/EXT1/NRP2/A2M/LRP6/TWIST1/YAP1/ZFP36L2/ABL1/SEMA6D/LTBP3/ZNF281/N4BP2L2/JAG1/STAT3 29 GO:0007492 endoderm development 17/803 77/18722 2.07748548161623e-08 1.39977602855926e-06 COL6A1/COL5A1/MMP2/VTN/COL11A1/GATA6/GATA4/BMP4/COL5A2/COL4A2/LAMC1/EXT1/ZFP36L1/LAMB1/EPB41L5/RTF1/BPTF 17 GO:0007369 gastrulation 27/803 185/18722 2.51032738405254e-08 1.66886564491813e-06 COL6A1/COL5A1/MMP2/VTN/COL11A1/GATA6/PHLDB1/BMP4/COL5A2/GPC3/GJA1/MYADM/COL4A2/TWSG1/ACVR2A/EXT1/UGDH/TGFBR2/ITGB1/LAMB1/KLF4/BMPR2/PRKAR1A/WNK1/FRS2/EPB41L5/RTF1 27 GO:0007015 actin filament organization 46/803 441/18722 2.54869812051492e-08 1.67208010906413e-06 SLIT2/SORBS2/SYNPO2/ELN/DPYSL3/PLEKHH2/MYO1B/LMOD1/LPAR1/TPM2/FSCN1/BIN1/CDC42EP5/PLS3/MARCKS/MYADM/GAS7/CALD1/FLNA/SPTBN1/NEBL/MYO1E/RND3/CFL2/ENAH/PIK3R1/ROCK2/ABI2/EPS8/SORBS3/DLC1/TPM4/NCKAP1/ABL1/ARHGAP28/PLEC/TPM1/HSP90B1/TTC17/WASL/FER/MYO1C/CCDC88A/GSN/TJP1/CDC42EP3 46 GO:0014706 striated muscle tissue development 42/803 384/18722 2.71088407789408e-08 1.73288051440768e-06 DCN/BMP5/TCF21/PDGFRA/WNT2/SORBS2/ELN/COL11A1/MSC/PDGFRB/TBX2/GATA6/PITX1/GATA4/BMP4/HEG1/GJA1/EFNB2/IGF2/NEBL/TGFBR3/CFL2/PTEN/SGCB/SMAD5/PDLIM5/TWIST1/TGFBR2/YAP1/NUPR1/ENG/ITGB1/NOTCH2/DDX17/PRKAR1A/PLEC/TPM1/FRS2/SKI/PRKAA1/SLC8A1/AKAP13 42 GO:0042692 muscle cell differentiation 42/803 384/18722 2.71088407789408e-08 1.73288051440768e-06 PDGFRA/ADAMTS5/SORBS2/IGFBP5/PDGFRB/EFEMP2/EHD2/TBX2/GATA6/PRDM6/ADAMTS15/GATA4/LMOD1/BMP4/EDNRB/BIN1/ADAM12/EFNB2/IGF2/CD9/NEBL/CD81/CFL2/PIEZO1/SGCB/PDLIM5/ENG/ITGB1/SDC1/BMPR2/PRKAR1A/CAPN2/PLEC/TPM1/SYNE1/PLD3/FRS2/SKI/SLC8A1/SORT1/AKAP13/ACTN4 42 GO:0048738 cardiac muscle tissue development 31/803 236/18722 2.97110734445095e-08 1.87518243283955e-06 BMP5/PDGFRA/WNT2/SORBS2/COL11A1/MSC/PDGFRB/TBX2/GATA6/GATA4/BMP4/HEG1/GJA1/EFNB2/NEBL/TGFBR3/PTEN/SGCB/SMAD5/PDLIM5/TGFBR2/YAP1/ENG/ITGB1/NOTCH2/PRKAR1A/PLEC/TPM1/FRS2/SLC8A1/AKAP13 31 GO:0085029 extracellular matrix assembly 13/803 45/18722 3.08391185977801e-08 1.92204806660665e-06 COL1A2/MFAP4/TNXB/FBLN5/ANTXR1/EFEMP2/EMILIN1/PHLDB1/GAS6/FKBP10/LAMB2/LAMB1/LTBP3 13 GO:0048675 axon extension 21/803 120/18722 3.71261916365078e-08 2.28532335184726e-06 NDN/SLIT2/SLIT3/MAP1B/APOE/SEMA3B/ALCAM/LAMB2/NRCAM/LRP1/NRP2/ITGB1/BMPR2/ABL1/SEMA6D/RTN4/VCL/DPYSL2/MACF1/GOLGA4/USP9X 21 GO:0032835 glomerulus development 15/803 62/18722 3.79688040790546e-08 2.30868850168495e-06 TCF21/PDGFRA/NID1/PDGFRB/BMP4/PROM1/ACTA2/ANGPT1/MYO1E/LAMB2/EXT1/BASP1/SULF2/NOTCH2/JAG1 15 GO:0007409 axonogenesis 44/803 418/18722 3.93963874816328e-08 2.36663118052315e-06 CDH11/NDN/LAMA2/SLIT2/THY1/SLIT3/NFASC/FLRT3/MAP1B/EPHA3/CHN1/APOE/NEXN/EFNB2/PALLD/SEMA3B/ALCAM/NFIB/PTEN/LAMB2/NRCAM/EXT1/ENAH/ROBO1/LRP1/NRP2/S100A6/NOTCH3/NIN/ITGB1/NOTCH2/BMPR2/ABL1/SEMA6D/SKIL/RTN4/VCL/PLXNB2/NPTN/DPYSL2/SOS1/MACF1/GOLGA4/USP9X 44 GO:0034329 cell junction assembly 44/803 420/18722 4.53101382452422e-08 2.68948034869974e-06 APOD/CDH11/THY1/COL16A1/FLRT3/PTPRD/MAP1B/EPHA3/SNAI2/THBS1/AMIGO2/HEG1/FSCN1/GJA1/PRKCA/PEAK1/LAMC1/EFNB2/CLDN1/CD9/PTEN/DST/NRCAM/PDLIM5/LRP1/MTDH/PTPRK/ROCK2/MPDZ/DLC1/PTPRA/ABL1/PLEC/VCL/PLXNB2/NPTN/EPB41L5/CLSTN1/MYO1C/MAP4K4/HIPK1/TJP1/MACF1/FARP1 44 GO:0003180 aortic valve morphogenesis 11/803 32/18722 4.7648097369662e-08 2.79498133511923e-06 SLIT2/ELN/SLIT3/EMILIN1/SNAI2/GATA4/BMP4/ROBO1/ROCK2/TWIST1/JAG1 11 GO:0043010 camera-type eye development 37/803 322/18722 5.1445287967703e-08 2.98263030008101e-06 PDGFRA/WNT2/PITX2/THY1/LAMC3/PDGFRB/COL8A2/TBX2/BMP4/PROM1/CRYAB/MAF/OSR2/COL4A1/SPRY1/TWSG1/VIM/RDH10/SERPINF1/LAMB2/TWIST1/TGFBR2/ABI2/SPRED1/NOTCH2/KLF4/FBN1/BMPR2/JAG1/SKIL/FRS2/SKI/SP3/HIPK1/CEP290/PKNOX1/SOS1 37 GO:0035051 cardiocyte differentiation 24/803 156/18722 5.3537063704246e-08 3.05396825992346e-06 PDGFRA/PITX2/VCAM1/SORBS2/HAND2/PDGFRB/TBX2/GATA6/GATA4/BMP4/PRICKLE1/SPRY1/EFNB2/NEBL/TGFBR3/SGCB/PDLIM5/TWIST1/ITGB1/PLEC/JAG1/FRS2/SLC8A1/AKAP13 24 GO:0003179 heart valve morphogenesis 14/803 55/18722 5.39007635124879e-08 3.05396825992346e-06 SLIT2/ELN/SLIT3/EMILIN1/SNAI2/GATA4/BMP4/ROBO1/ROCK2/TWIST1/TGFBR2/NOTCH2/BMPR2/JAG1 14 GO:0048844 artery morphogenesis 16/803 74/18722 7.38664259853575e-08 4.13817977486509e-06 HAND2/PDGFRB/EFEMP2/TBX2/HOXA13/BMP4/APOE/MYLK/FKBP10/MDK/LRP1/PKD2/ENG/BMPR2/JAG1/ZMIZ1 16 GO:0045765 regulation of angiogenesis 38/803 342/18722 8.27430017529992e-08 4.57960393345121e-06 DCN/HGF/ENPP2/F3/ECM1/ADGRA2/CREB3L1/EMILIN1/SMOC2/ISM1/GATA6/GATA4/SPARC/THBS1/ADAM12/PRKCA/ADAMTS1/COL4A2/SERPINF1/RRAS/GPNMB/HSPG2/PDE3B/MDK/MTDH/ROCK2/TWIST1/TGFBR2/ENG/ITGB1/SPRED1/KLF4/ABL1/STAT3/HIPK1/TJP1/HSPB1/JAK1 38 GO:1903035 negative regulation of response to wounding 18/803 94/18722 8.35828234945969e-08 4.57960393345121e-06 PDGFRA/FAP/WFDC1/PROS1/VTN/PRKG1/SERPINE2/THBS1/APOE/GJA1/PLAU/CD9/SERPING1/CASK/PTEN/MDK/TFPI/CERS2 18 GO:0016055 Wnt signaling pathway 45/803 444/18722 8.46732848351081e-08 4.58892389334619e-06 COL1A1/CTHRC1/WNT2/IGFBP2/ADGRA2/RSPO3/DKK3/RSPO2/MCC/BICC1/SNAI2/GPC3/APOE/BAMBI/ZEB2/PLPP3/PRICKLE1/MLLT3/PTK7/RBMS3/PTEN/EXT1/PKD1/MDK/LRP1/APCDD1/PKD2/LRP6/YAP1/SULF2/KLF4/SDC1/ABL1/WNK1/TBL1XR1/DAB2/AMFR/FOXO3/SKI/PRKAA1/RTF1/MACF1/DAAM1/AMOTL2/USP47 45 GO:0198738 cell-cell signaling by wnt 45/803 446/18722 9.65450636224588e-08 5.17606115292021e-06 COL1A1/CTHRC1/WNT2/IGFBP2/ADGRA2/RSPO3/DKK3/RSPO2/MCC/BICC1/SNAI2/GPC3/APOE/BAMBI/ZEB2/PLPP3/PRICKLE1/MLLT3/PTK7/RBMS3/PTEN/EXT1/PKD1/MDK/LRP1/APCDD1/PKD2/LRP6/YAP1/SULF2/KLF4/SDC1/ABL1/WNK1/TBL1XR1/DAB2/AMFR/FOXO3/SKI/PRKAA1/RTF1/MACF1/DAAM1/AMOTL2/USP47 45 GO:0035904 aorta development 14/803 58/18722 1.11412701281844e-07 5.90961413394974e-06 LOXL1/PDGFRB/EFEMP2/TBX2/MYLK/PRICKLE1/FKBP10/ROBO1/LRP1/PKD2/ENG/AP2B1/JAG1/HECTD1 14 GO:0030510 regulation of BMP signaling pathway 18/803 96/18722 1.1708917651124e-07 6.14533299036889e-06 FST/HOXA13/GATA4/BMP4/GPC3/BAMBI/TWSG1/HTRA1/FSTL1/ENG/NOTCH2/FBN1/PCSK6/BMPR2/ABL1/SKIL/SKI/CRIM1 18 GO:1901342 regulation of vasculature development 38/803 348/18722 1.30277821512203e-07 6.76630435479006e-06 DCN/HGF/ENPP2/F3/ECM1/ADGRA2/CREB3L1/EMILIN1/SMOC2/ISM1/GATA6/GATA4/SPARC/THBS1/ADAM12/PRKCA/ADAMTS1/COL4A2/SERPINF1/RRAS/GPNMB/HSPG2/PDE3B/MDK/MTDH/ROCK2/TWIST1/TGFBR2/ENG/ITGB1/SPRED1/KLF4/ABL1/STAT3/HIPK1/TJP1/HSPB1/JAK1 38 GO:0048041 focal adhesion assembly 17/803 87/18722 1.40106536960778e-07 7.20176487924166e-06 APOD/THY1/COL16A1/EPHA3/THBS1/PEAK1/PTEN/LRP1/PTPRK/ROCK2/DLC1/PTPRA/ABL1/VCL/EPB41L5/MAP4K4/MACF1 17 GO:0060411 cardiac septum morphogenesis 15/803 68/18722 1.42374849373526e-07 7.24368366302448e-06 BMP5/SLIT2/SLIT3/TBX2/GATA6/GATA4/BMP4/TGFBR3/ROBO1/NRP2/TGFBR2/ENG/NOTCH2/BMPR2/JAG1 15 GO:0061045 negative regulation of wound healing 16/803 78/18722 1.60870908809174e-07 8.10204395275297e-06 PDGFRA/FAP/WFDC1/PROS1/VTN/PRKG1/SERPINE2/THBS1/APOE/GJA1/PLAU/CD9/SERPING1/CASK/PTEN/TFPI 16 GO:0035265 organ growth 25/803 178/18722 1.75888960838962e-07 8.76982358743065e-06 FGF7/WNT2/STC1/SORBS2/DDR2/ECM1/PDGFRB/TBX2/GATA6/RSPO2/MAEL/GATA4/HEG1/GJA1/IGF2/TGFBR3/BNC2/PTEN/EXT1/BASP1/PDLIM5/TGFBR2/YAP1/PRKAR1A/AKAP13 25 GO:0031346 positive regulation of cell projection organization 38/803 353/18722 1.88344645757752e-07 9.20038152049314e-06 HGF/BMP5/ENPP2/SLIT2/PTPRD/MAP1B/EPHA3/DPYSL3/PALM/APOE/FSCN1/CDC42EP5/FLNA/SERPINF1/PTK7/TMEM106B/ROBO1/MDK/LRP1/PIK3R1/NIN/ABI2/EPS8/RHOQ/SCARB2/BMPR2/NCKAP1/SKIL/SETX/PLXNB2/NPTN/WASL/CCDC88A/VLDLR/MACF1/KIDINS220/CDC42EP3/GOLGA4 38 GO:1902903 regulation of supramolecular fiber organization 40/803 382/18722 1.88455364502027e-07 9.20038152049314e-06 AEBP1/SLIT2/SYNPO2/ELN/EFEMP2/EMILIN1/MAP1B/PLEKHH2/LMOD1/CRYAB/LPAR1/APOE/BIN1/CDC42EP5/MYADM/FLNA/SPTBN1/CFL2/COLGALT1/CLU/PIK3R1/ROCK2/NIN/ABI2/EPS8/SORBS3/DLC1/NCKAP1/ABL1/ARHGAP28/TAOK1/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/TJP1/CDC42EP3/AKAP13 40 GO:0010717 regulation of epithelial to mesenchymal transition 18/803 99/18722 1.90742513267849e-07 9.20038152049314e-06 COL1A1/BMP5/PDPN/EPHA3/PHLDB1/VASN/BMP4/LDLRAD4/BAMBI/SPRY1/PTEN/MDK/TWIST1/TGFBR2/ENG/SPRED1/JAG1/DAB2 18 GO:0051146 striated muscle cell differentiation 33/803 283/18722 1.91905270383331e-07 9.20038152049314e-06 PDGFRA/ADAMTS5/SORBS2/IGFBP5/PDGFRB/EHD2/GATA6/ADAMTS15/GATA4/LMOD1/BMP4/ADAM12/EFNB2/IGF2/CD9/NEBL/CD81/CFL2/PIEZO1/SGCB/PDLIM5/ITGB1/SDC1/PRKAR1A/CAPN2/PLEC/TPM1/PLD3/FRS2/SKI/SLC8A1/SORT1/AKAP13 33 GO:1901888 regulation of cell junction assembly 27/803 204/18722 1.97062349426951e-07 9.3576464213598e-06 APOD/THY1/COL16A1/FLRT3/PTPRD/EPHA3/SNAI2/THBS1/AMIGO2/GJA1/PEAK1/CLDN1/PTEN/PDLIM5/LRP1/ROCK2/DLC1/PTPRA/ABL1/VCL/EPB41L5/CLSTN1/MYO1C/MAP4K4/TJP1/MACF1/FARP1 27 GO:0045667 regulation of osteoblast differentiation 21/803 132/18722 2.02078308000557e-07 9.50530607255449e-06 HGF/CTHRC1/IGFBP5/DDR2/HAND2/SNAI2/BMP4/BAMBI/IL6ST/TWSG1/ACVR2A/IFITM1/PDLIM7/SMAD5/TWIST1/YAP1/BMPR2/JAG1/SKI/NBR1/CRIM1 21 GO:0001890 placenta development 22/803 144/18722 2.16549908683567e-07 1.00908209784698e-05 DCN/BMP5/WNT2/STC1/HSD17B2/RSPO3/PLAC1/GJA1/IGF2/HTRA1/PKD1/EPAS1/PKD2/SOCS3/ZFP36L1/NOTCH2/BMPR2/ASH1L/SP3/HECTD1/BPTF/NCOA1 22 GO:0048588 developmental cell growth 29/803 234/18722 2.92089931476573e-07 1.34848185031685e-05 NDN/SLIT2/SORBS2/SLIT3/FLRT3/MAP1B/GATA4/APOE/SEMA3B/ALCAM/LAMB2/NRCAM/EXT1/PDLIM5/LRP1/NRP2/TGFBR2/NIN/ITGB1/BMPR2/ABL1/SEMA6D/RTN4/VCL/DPYSL2/MACF1/AKAP13/GOLGA4/USP9X 29 GO:0007162 negative regulation of cell adhesion 34/803 303/18722 3.14403609945847e-07 1.41988541577258e-05 COL1A1/APOD/PRKG1/SNAI2/TGFBI/BMP4/SERPINE2/THBS1/ANGPT1/MYADM/TWSG1/LGALS1/CD9/CASK/PTEN/GPNMB/PDE3B/MDK/LRP1/PIK3R1/PRNP/PAG1/DLC1/KLF4/PRKAR1A/ABL1/WNK1/FBLN1/JAG1/PLXNB2/EPB41L5/MAP4K4/NDFIP1/ACTN4 34 GO:0060070 canonical Wnt signaling pathway 34/803 303/18722 3.14403609945847e-07 1.41988541577258e-05 COL1A1/CTHRC1/WNT2/IGFBP2/ADGRA2/RSPO3/DKK3/RSPO2/MCC/BICC1/SNAI2/GPC3/APOE/BAMBI/ZEB2/PLPP3/PRICKLE1/MLLT3/PTK7/RBMS3/PTEN/EXT1/MDK/LRP6/YAP1/SULF2/KLF4/SDC1/WNK1/TBL1XR1/DAB2/AMFR/FOXO3/USP47 34 GO:0031032 actomyosin structure organization 26/803 196/18722 3.16099641297144e-07 1.41988541577258e-05 PDGFRA/ELN/PDGFRB/LMOD1/LPAR1/FRMD3/EPB41L2/NEBL/CFL2/CNN3/CDC42BPA/PIK3R1/ROCK2/ITGB1/SORBS3/DLC1/PRKAR1A/CNN2/ABL1/ARHGAP28/PLEC/TPM1/EPB41L5/CCDC88A/TJP1/AKAP13 26 GO:0060973 cell migration involved in heart development 8/803 18/18722 3.3006270980021e-07 1.469368456307e-05 PITX2/HAND2/PDGFRB/FLRT3/SNAI2/BMP4/TWIST1/ENG 8 GO:0016049 cell growth 46/803 482/18722 3.52618424548535e-07 1.55588979185752e-05 MEG3/ENPP1/NDN/FBLN5/SLIT2/SORBS2/IGFBP5/LTBP4/WFDC1/FHL1/SLIT3/FLRT3/MAP1B/GATA4/SERPINE2/CRYAB/APOE/GJA1/SEMA3B/ALCAM/LAMB2/NRCAM/EXT1/CAMK2D/PDLIM5/LRP1/NRP2/SOCS2/CISH/TGFBR2/NIN/BST2/ITGB1/BMPR2/ABL1/SEMA6D/RTN4/VCL/EPB41L5/DPYSL2/CLSTN1/MACF1/AKAP13/GOLGA4/USP47/USP9X 46 GO:0045785 positive regulation of cell adhesion 43/803 437/18722 3.72387106312235e-07 1.62870360708141e-05 EGFL6/PDPN/FBLN2/IGFBP2/NID1/VCAM1/THY1/CSF1/COL16A1/EFEMP2/EMILIN1/CD36/ANGPT1/PRKCA/PLPP3/IL6ST/MYADM/MYO10/FLNA/IGF2/LGALS1/HLA-A/CD81/PIEZO1/RRAS/CCDC80/MDK/DPP4/B2M/NFAT5/RIN2/TGFBR2/MAP3K8/PLAUR/ABL1/TPM1/EPB41L5/ZMIZ1/MAP4K4/TJP1/ATM/ZFHX3/JAK1 43 GO:0031099 regeneration 26/803 198/18722 3.8646069145235e-07 1.67555913702732e-05 HGF/APOD/THY1/NNMT/MAP1B/GATA4/GAS6/FLNA/CLDN1/CD9/CD81/TGFBR3/PTEN/LAMB2/MDK/LRP1/AXL/TSPO/TGFBR2/YAP1/SULF2/KLF4/LPIN1/IGF2R/MAP4K4/CERS2 26 GO:0010632 regulation of epithelial cell migration 33/803 292/18722 3.97435052168125e-07 1.70828549147437e-05 DCN/FGF7/ENPP2/STC1/SLIT2/ADGRA2/SMOC2/MCC/BMP4/SPARC/THBS1/APOE/FGFR1/ANGPT1/PRKCA/PLPP3/SERPINF1/PTEN/RRAS/NRP2/RIN2/ROCK2/TGFBR2/SPRED1/PTPRG/KLF4/BMPR2/ABL1/RTN4/EPB41L5/MAP4K4/MACF1/HSPB1 33 GO:0001885 endothelial cell development 14/803 64/18722 4.13835606385463e-07 1.76357635336574e-05 COL15A1/STC1/HOXA13/HEG1/MYADM/CLDN1/ROCK2/PLCB1/TNFRSF1A/VCL/MSN/ZDHHC21/TJP1/GSTM3 14 GO:0048771 tissue remodeling 24/803 175/18722 4.82742160111546e-07 2.03979017823404e-05 CTHRC1/MMP2/IGFBP5/DDR2/HAND2/RSPO3/CTSK/TIMP1/GJA1/PRKCA/FLNA/PDK4/GPNMB/EXT1/MDK/AXL/EPAS1/ROCK2/NOTCH2/BMPR2/LTBP3/GPR137B/JAG1/P3H4 24 GO:0048592 eye morphogenesis 22/803 151/18722 5.03178299312963e-07 2.10827479023061e-05 WNT2/COL5A1/PITX2/THY1/COL8A2/TBX2/BMP4/PROM1/MFAP2/COL5A2/TWIST1/ABI2/NOTCH2/FBN1/TUG1/JAG1/FRS2/SKI/STAT3/SP3/HIPK1/CEP290 22 GO:0007411 axon guidance 28/803 227/18722 5.14285422580186e-07 2.13685593082067e-05 LAMA2/SLIT2/SLIT3/NFASC/FLRT3/EPHA3/CHN1/NEXN/EFNB2/PALLD/SEMA3B/ALCAM/NFIB/LAMB2/NRCAM/EXT1/ENAH/ROBO1/LRP1/NRP2/NOTCH3/NOTCH2/BMPR2/SEMA6D/PLXNB2/NPTN/DPYSL2/SOS1 28 GO:0002062 chondrocyte differentiation 18/803 106/18722 5.5234885847195e-07 2.27604248623235e-05 CYTL1/ECM1/COL11A1/SOX5/GDF6/SNAI2/TGFBI/BMP4/MAF/OSR2/NFIB/EXT1/MDK/SERPINH1/TGFBR2/SULF2/BMPR2/LTBP3 18 GO:0097485 neuron projection guidance 28/803 228/18722 5.62893775661543e-07 2.30048226676103e-05 LAMA2/SLIT2/SLIT3/NFASC/FLRT3/EPHA3/CHN1/NEXN/EFNB2/PALLD/SEMA3B/ALCAM/NFIB/LAMB2/NRCAM/EXT1/ENAH/ROBO1/LRP1/NRP2/NOTCH3/NOTCH2/BMPR2/SEMA6D/PLXNB2/NPTN/DPYSL2/SOS1 28 GO:0030193 regulation of blood coagulation 14/803 66/18722 6.1817547184738e-07 2.50587227856182e-05 PDGFRA/F3/FAP/PROS1/VTN/PRKG1/CD36/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 14 GO:0009612 response to mechanical stimulus 27/803 216/18722 6.28230751318096e-07 2.51647699636554e-05 DCN/COL3A1/COL1A1/IGFBP2/COL11A1/MAP1B/GATA4/SERPINE2/THBS1/PPL/GJA1/MEIS2/PIEZO1/PKD1/MDK/PKD2/TGFBR2/TXNIP/ENG/TNFRSF1A/CNN2/TMEM120A/PLEC/SLC38A2/SLC8A1/GSN/LTBR 27 GO:0045446 endothelial cell differentiation 19/803 118/18722 6.30885729132957e-07 2.51647699636554e-05 COL15A1/PDPN/STC1/HOXA13/BMP4/HEG1/MYADM/CLDN1/FSTL1/ROCK2/PLCB1/TNFRSF1A/BMPR2/JAG1/VCL/MSN/ZDHHC21/TJP1/GSTM3 19 GO:0007596 blood coagulation 27/803 217/18722 6.88899195895266e-07 2.72607253232841e-05 COL3A1/PDGFRA/PDPN/F3/MYL9/FAP/PROS1/VTN/PRKG1/GAS6/CD36/SERPINE2/THBS1/APOE/PRKCA/IL6ST/PLAU/FLNA/CD9/SERPING1/TFPI/AXL/RAP2B/PLAUR/FBLN1/VCL/HSPB1 27 GO:0030195 negative regulation of blood coagulation 12/803 49/18722 7.6180890764813e-07 2.99084977443589e-05 PDGFRA/FAP/PROS1/VTN/PRKG1/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 12 GO:0032102 negative regulation of response to external stimulus 41/803 420/18722 8.55216277519123e-07 3.33133465602371e-05 HGF/PDGFRA/SLIT2/FAP/WFDC1/PROS1/VTN/SPX/PRKG1/SERPINE2/THBS1/APOE/GJA1/PLAU/HLA-B/CD9/SERPING1/CASK/HLA-A/MFHAS1/SERPINF1/HTRA1/SEMA3B/PTEN/ROBO1/MDK/TFPI/DPP4/A2M/SOCS3/TNFRSF1A/KLF4/SEMA6D/HLA-F/ASH1L/METRNL/CERS2/IFI16/SERPINB9/NDFIP1/TSPAN6 41 GO:0061318 renal filtration cell differentiation 8/803 20/18722 8.80107296067039e-07 3.37554998322328e-05 BMP4/PROM1/MYO1E/LAMB2/EXT1/BASP1/NOTCH2/JAG1 8 GO:0072112 glomerular visceral epithelial cell differentiation 8/803 20/18722 8.80107296067039e-07 3.37554998322328e-05 BMP4/PROM1/MYO1E/LAMB2/EXT1/BASP1/NOTCH2/JAG1 8 GO:1900046 regulation of hemostasis 14/803 68/18722 9.08738889536989e-07 3.45875733071101e-05 PDGFRA/F3/FAP/PROS1/VTN/PRKG1/CD36/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 14 GO:0070482 response to oxygen levels 36/803 347/18722 9.60937116577903e-07 3.61232369764937e-05 COL1A1/PDPN/MMP2/STC1/VCAM1/PDGFRB/GATA6/VASN/HIF3A/THBS1/CRYAB/KCNMA1/SOD3/PLAU/PLOD2/ATP1B1/TGFBR3/PTEN/DPP4/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/TGFBR2/NDRG1/MALAT1/ZFP36L1/CAPN2/HSP90B1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 36 GO:1900047 negative regulation of hemostasis 12/803 50/18722 9.63576116701495e-07 3.61232369764937e-05 PDGFRA/FAP/PROS1/VTN/PRKG1/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 12 GO:0061138 morphogenesis of a branching epithelium 24/803 182/18722 9.95505134700897e-07 3.70417059822289e-05 HGF/TCF21/FGF7/WNT2/SLIT2/RSPO3/CSF1/RSPO2/HOXA13/BMP4/GPC3/COL4A1/SPRY1/RDH10/EXT1/PKD1/MDK/PKD2/SOCS3/TGFBR2/YAP1/ENG/ABL1/FRS2 24 GO:0007599 hemostasis 27/803 222/18722 1.08183327820989e-06 3.96619170967243e-05 COL3A1/PDGFRA/PDPN/F3/MYL9/FAP/PROS1/VTN/PRKG1/GAS6/CD36/SERPINE2/THBS1/APOE/PRKCA/IL6ST/PLAU/FLNA/CD9/SERPING1/TFPI/AXL/RAP2B/PLAUR/FBLN1/VCL/HSPB1 27 GO:0050817 coagulation 27/803 222/18722 1.08183327820989e-06 3.96619170967243e-05 COL3A1/PDGFRA/PDPN/F3/MYL9/FAP/PROS1/VTN/PRKG1/GAS6/CD36/SERPINE2/THBS1/APOE/PRKCA/IL6ST/PLAU/FLNA/CD9/SERPING1/TFPI/AXL/RAP2B/PLAUR/FBLN1/VCL/HSPB1 27 GO:0048251 elastic fiber assembly 6/803 10/18722 1.10686752077004e-06 3.99759781317375e-05 MFAP4/TNXB/FBLN5/EFEMP2/EMILIN1/LTBP3 6 GO:0001763 morphogenesis of a branching structure 25/803 196/18722 1.11496195412783e-06 3.99759781317375e-05 HGF/TCF21/FGF7/WNT2/SLIT2/RSPO3/CSF1/RSPO2/HOXA13/BMP4/GPC3/COL4A1/SPRY1/RDH10/EXT1/PKD1/MDK/PKD2/SOCS3/TGFBR2/YAP1/ENG/ABL1/RTN4/FRS2 25 GO:0050878 regulation of body fluid levels 38/803 379/18722 1.12247030454137e-06 3.99759781317375e-05 COL3A1/PDGFRA/PDPN/F3/MYL9/FAP/PROS1/VTN/PRKG1/GAS6/CD36/SERPINE2/THBS1/EDNRB/APOE/HEG1/PRLR/GJA1/PRKCA/IL6ST/PLAU/FLNA/CLDN1/CD9/SERPING1/EXT1/NCOR2/TFPI/AXL/SOCS2/RAP2B/PLAUR/PLEC/WNK1/FBLN1/VCL/HSPB1/NCOA1 38 GO:0051346 negative regulation of hydrolase activity 38/803 379/18722 1.12247030454137e-06 3.99759781317375e-05 HGF/COL6A3/WFDC1/PROS1/ECM1/VTN/GAS6/SERPINE2/GPC3/THBS1/CRYAB/TIMP1/BIN1/SPRY1/SERPING1/SERPINF1/CNN3/TIMP3/LRP1/TFPI/A2M/SERPINH1/ROCK2/PRNP/PXK/BST2/KLF4/PLAUR/ABL1/TIMP2/PLA2R1/WNK1/IFI16/SORT1/TERF1/SERPINB9/CRIM1/USP47 38 GO:0003231 cardiac ventricle development 19/803 123/18722 1.21169408503047e-06 4.28475653046944e-05 SLIT2/HAND2/COL11A1/SLIT3/HOXA13/GATA4/BMP4/HEG1/TGFBR3/PTK7/ROBO1/TGFBR2/ENG/BMPR2/AP2B1/TPM1/JAG1/FRS2/HECTD1 19 GO:0001666 response to hypoxia 33/803 307/18722 1.23815410737513e-06 4.32803176024761e-05 MMP2/STC1/VCAM1/GATA6/VASN/HIF3A/THBS1/CRYAB/KCNMA1/SOD3/PLAU/PLOD2/ATP1B1/TGFBR3/PTEN/DPP4/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/TGFBR2/NDRG1/MALAT1/ZFP36L1/CAPN2/HSP90B1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 33 GO:0034109 homotypic cell-cell adhesion 16/803 90/18722 1.24129270299921e-06 4.32803176024761e-05 PDGFRA/PDPN/MYL9/PRKG1/SERPINE2/PRKCA/PLPP3/IL6ST/FLNA/LGALS1/CD9/RAP2B/PLAUR/VCL/HSPB1/JAK1 16 GO:0072311 glomerular epithelial cell differentiation 8/803 21/18722 1.36832266492745e-06 4.73781722731131e-05 BMP4/PROM1/MYO1E/LAMB2/EXT1/BASP1/NOTCH2/JAG1 8 GO:0003158 endothelium development 20/803 136/18722 1.41865673238886e-06 4.87822239151092e-05 COL15A1/PDPN/STC1/HOXA13/BMP4/HEG1/GJA1/MYADM/CLDN1/FSTL1/ROCK2/PLCB1/TNFRSF1A/BMPR2/JAG1/VCL/MSN/ZDHHC21/TJP1/GSTM3 20 GO:0003281 ventricular septum development 14/803 71/18722 1.57530217002479e-06 5.34316776853306e-05 SLIT2/SLIT3/HOXA13/GATA4/BMP4/HEG1/TGFBR3/PTK7/ROBO1/TGFBR2/BMPR2/AP2B1/FRS2/HECTD1 14 GO:0050818 regulation of coagulation 14/803 71/18722 1.57530217002479e-06 5.34316776853306e-05 PDGFRA/F3/FAP/PROS1/VTN/PRKG1/CD36/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 14 GO:0072659 protein localization to plasma membrane 31/803 284/18722 1.87258793656622e-06 6.29476722789894e-05 NFASC/EHD2/EPHA3/GAS6/PALM/SLC9A3R2/MYADM/FLNA/RAMP1/SPTBN1/ATP1B1/TSPAN5/CD81/LRP1/PIK3R1/ROCK2/LRP6/PRNP/RAP2A/TNFRSF1A/ITGB1/RHOQ/PID1/PREPL/DAB2/TMEM59/CCDC88A/CLTC/HECTD1/MACF1/GOLGA4 31 GO:0050819 negative regulation of coagulation 12/803 53/18722 1.88110773557349e-06 6.29476722789894e-05 PDGFRA/FAP/PROS1/VTN/PRKG1/SERPINE2/THBS1/APOE/PLAU/CD9/SERPING1/TFPI 12 GO:0003197 endocardial cushion development 11/803 45/18722 2.24909573597611e-06 7.47599422638458e-05 BMP5/TBX2/SNAI2/GATA4/BMP4/ROBO1/TWIST1/TGFBR2/ENG/BMPR2/JAG1 11 GO:0003012 muscle system process 42/803 452/18722 2.27450057422162e-06 7.51037077024436e-05 STC1/MYL9/SORBS2/IGFBP5/HAND2/SPX/DES/FXYD1/TBX2/PRKG1/GATA6/GATA4/LMOD1/CRYAB/EDNRB/ACTA2/TPM2/MYLK/KCNMA1/GJA1/BIN1/PRKCA/IL6ST/CALD1/FLNA/ATP1B1/CAMK2D/SMAD5/PDLIM5/LMCD1/ROCK2/APBB2/SULF2/TNFRSF1A/KLF4/TPM4/TPM1/FOXO3/SLC8A1/ZDHHC21/GSN/AKAP13 42 GO:0003151 outflow tract morphogenesis 14/803 74/18722 2.64846967975486e-06 8.68767751530114e-05 PITX2/HAND2/ELN/TBX2/GATA6/BMP4/TGFBR3/ROBO1/NRP2/TWIST1/TGFBR2/ENG/BMPR2/JAG1 14 GO:1990778 protein localization to cell periphery 34/803 333/18722 2.74010561739373e-06 8.92952065903605e-05 NFASC/EHD2/EPHA3/GAS6/PALM/SLC9A3R2/EPB41L2/MYADM/FLNA/RAMP1/SPTBN1/ATP1B1/TSPAN5/CD81/LRP1/GNAI1/PIK3R1/ROCK2/LRP6/PRNP/RAP2A/TNFRSF1A/ITGB1/RHOQ/PID1/PREPL/DAB2/TMEM59/CLSTN1/CCDC88A/CLTC/HECTD1/MACF1/GOLGA4 34 GO:0072006 nephron development 20/803 142/18722 2.81859980189177e-06 9.1256744235275e-05 TCF21/PDGFRA/NID1/PDGFRB/BMP4/PROM1/GPC3/ACTA2/ANGPT1/MYO1E/LAMB2/EXT1/BASP1/PKD1/PKD2/SEC61A1/YAP1/SULF2/NOTCH2/JAG1 20 GO:0001656 metanephros development 15/803 85/18722 2.92643735314764e-06 9.41368815664138e-05 TCF21/PDGFRA/PDGFRB/GDF6/BMP4/GPC3/OSR2/SPRY1/RDH10/LAMB2/BASP1/PKD1/PKD2/YAP1/FBN1 15 GO:0010466 negative regulation of peptidase activity 29/803 262/18722 3.02726411945265e-06 9.67560185871214e-05 HGF/COL6A3/WFDC1/PROS1/ECM1/VTN/GAS6/SERPINE2/GPC3/THBS1/CRYAB/TIMP1/BIN1/SERPING1/SERPINF1/TIMP3/LRP1/TFPI/A2M/SERPINH1/PRNP/BST2/KLF4/PLAUR/TIMP2/IFI16/SERPINB9/CRIM1/USP47 29 GO:0060389 pathway-restricted SMAD protein phosphorylation 13/803 65/18722 3.13622633273187e-06 9.93986198379038e-05 BMP5/EMILIN1/GDF6/BMP4/LDLRAD4/TWSG1/ACVR2A/TGFBR3/LRP1/TGFBR2/ENG/BMPR2/DAB2 13 GO:0045766 positive regulation of angiogenesis 23/803 181/18722 3.1697514148068e-06 9.93986198379038e-05 HGF/F3/ECM1/SMOC2/GATA6/GATA4/THBS1/ADAM12/PRKCA/RRAS/MDK/MTDH/TWIST1/TGFBR2/ENG/ITGB1/KLF4/ABL1/STAT3/HIPK1/TJP1/HSPB1/JAK1 23 GO:1904018 positive regulation of vasculature development 23/803 181/18722 3.1697514148068e-06 9.93986198379038e-05 HGF/F3/ECM1/SMOC2/GATA6/GATA4/THBS1/ADAM12/PRKCA/RRAS/MDK/MTDH/TWIST1/TGFBR2/ENG/ITGB1/KLF4/ABL1/STAT3/HIPK1/TJP1/HSPB1/JAK1 23 GO:0048568 embryonic organ development 40/803 427/18722 3.24457973508017e-06 0.000101109215994436 BMP5/TCF21/RARRES2/CTHRC1/PDGFRA/WNT2/PITX2/HAND2/RSPO3/COL11A1/KITLG/TBX2/GATA4/BMP4/MFAP2/OSR2/TSHZ1/IGF2/RDH10/PTK7/PKD1/EPAS1/PKD2/TWIST1/SOCS3/TGFBR2/YAP1/ENG/ZFP36L1/NOTCH2/FBN1/KMT2A/FRS2/SP3/HIPK1/CEP290/MIB1/HECTD1/BPTF/NCOA1 40 GO:0000302 response to reactive oxygen species 26/803 222/18722 3.46203089278678e-06 0.000107215441189036 HGF/COL1A1/APOD/PDGFRA/MMP2/FBLN5/PDGFRB/CD36/CRYAB/APOE/SOD3/AXL/PKD2/PTPRK/SESN3/TXNIP/KLF4/SDC1/ABL1/CAPN2/TPM1/SETX/FOXO3/PRKAA1/FER/SLC8A1 26 GO:0036293 response to decreased oxygen levels 33/803 322/18722 3.53291364991185e-06 0.000108735231225065 MMP2/STC1/VCAM1/GATA6/VASN/HIF3A/THBS1/CRYAB/KCNMA1/SOD3/PLAU/PLOD2/ATP1B1/TGFBR3/PTEN/DPP4/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/TGFBR2/NDRG1/MALAT1/ZFP36L1/CAPN2/HSP90B1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 33 GO:1902905 positive regulation of supramolecular fiber organization 25/803 209/18722 3.63366449459927e-06 0.000111150007178356 SYNPO2/EFEMP2/MAP1B/LMOD1/LPAR1/APOE/BIN1/CDC42EP5/FLNA/CFL2/COLGALT1/CLU/ROCK2/NIN/ABI2/SORBS3/NCKAP1/ABL1/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/CDC42EP3 25 GO:0051017 actin filament bundle assembly 21/803 157/18722 3.71613362136793e-06 0.000112342907433805 SYNPO2/ELN/DPYSL3/MYO1B/LPAR1/FSCN1/PLS3/MARCKS/CALD1/FLNA/PIK3R1/ROCK2/EPS8/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/HSP90B1/CCDC88A/TJP1 21 GO:0043542 endothelial cell migration 30/803 279/18722 3.71772557693098e-06 0.000112342907433805 DCN/STC1/SLIT2/FAP/ADGRA2/SMOC2/BMP4/SPARC/THBS1/APOE/FGFR1/ANGPT1/PRKCA/PLPP3/EFNB2/SERPINF1/PTEN/RRAS/ROBO1/NRP2/FSTL1/DPP4/RIN2/ROCK2/ITGB1/SPRED1/KLF4/BMPR2/ABL1/HSPB1 30 GO:0052547 regulation of peptidase activity 42/803 461/18722 3.74938039709277e-06 0.000112616931686172 HGF/F3/COL6A3/WFDC1/ANTXR1/PCOLCE/PROS1/ECM1/VTN/GAS6/SERPINE2/GPC3/THBS1/CRYAB/TIMP1/BIN1/UACA/SERPING1/PCOLCE2/SERPINF1/TIMP3/ROBO1/LRP1/TFPI/A2M/SERPINH1/ROCK2/EGLN3/PRNP/BST2/DLC1/KLF4/PLAUR/TIMP2/FBLN1/DAPK1/STAT3/IFI16/GSN/SERPINB9/CRIM1/USP47 42 GO:0001704 formation of primary germ layer 18/803 121/18722 3.99610431337325e-06 0.000119308838960952 COL6A1/COL5A1/MMP2/VTN/COL11A1/GATA6/BMP4/COL5A2/GJA1/COL4A2/TWSG1/ITGB1/LAMB1/KLF4/BMPR2/PRKAR1A/EPB41L5/RTF1 18 GO:0048545 response to steroid hormone 34/803 339/18722 4.06469491023454e-06 0.000120634338228747 COL1A1/TCF21/IGFBP2/STC1/SLIT2/FIBIN/SLIT3/BMP4/SPARC/PLPP1/THBS1/KANK2/CLDN1/SERPINF1/PIAS2/MDK/NCOR2/TFPI/NR3C1/TSPO/TGFBR2/YAP1/ZFP36L2/TXNIP/ENG/ZFP36L1/SDC1/DDX17/DAB2/FOXO3/ZMIZ1/STRN3/CLOCK/NCOA1 34 GO:0061005 cell differentiation involved in kidney development 12/803 57/18722 4.25952048154944e-06 0.000125668456337311 TCF21/BMP4/PROM1/ACTA2/MYO1E/GLIS2/LAMB2/EXT1/BASP1/YAP1/NOTCH2/JAG1 12 GO:0060562 epithelial tube morphogenesis 33/803 325/18722 4.31480146224214e-06 0.000126550588769055 BMP5/TCF21/CTHRC1/WNT2/SLIT2/HAND2/CSF1/TBX2/RSPO2/GATA4/BMP4/GPC3/COL4A1/PRICKLE1/SPRY1/RDH10/PTK7/EXT1/PKD1/MDK/PKD2/TWIST1/TGFBR2/YAP1/ENG/NOTCH2/DLC1/ABL1/PLXNB2/SKI/CEP290/MIB1/HECTD1 33 GO:0003148 outflow tract septum morphogenesis 8/803 24/18722 4.40952095024658e-06 0.000127824834057729 TBX2/GATA6/BMP4/ROBO1/NRP2/TGFBR2/ENG/BMPR2 8 GO:0072010 glomerular epithelium development 8/803 24/18722 4.40952095024658e-06 0.000127824834057729 BMP4/PROM1/MYO1E/LAMB2/EXT1/BASP1/NOTCH2/JAG1 8 GO:1990138 neuron projection extension 22/803 172/18722 4.63324572038793e-06 0.000133533891108984 NDN/SLIT2/SLIT3/FLRT3/MAP1B/APOE/SEMA3B/ALCAM/LAMB2/NRCAM/LRP1/NRP2/ITGB1/BMPR2/ABL1/SEMA6D/RTN4/VCL/DPYSL2/MACF1/GOLGA4/USP9X 22 GO:0007517 muscle organ development 33/803 327/18722 4.92146525104357e-06 0.000140323342762496 DCN/TCF21/WNT2/LAMA2/COL6A3/FHL1/ELN/COL11A1/MSC/EFEMP2/PITX1/BMP4/CRYAB/HEG1/TAGLN/MYLK/IGF2/TGFBR3/CFL2/SGCB/BASP1/TWIST1/SGCE/NUPR1/ENG/DDX17/PLEC/TPM1/ARID5B/SKI/PRKAA1/TCF12/ZFHX3 33 GO:0090288 negative regulation of cellular response to growth factor stimulus 17/803 111/18722 4.92510729711931e-06 0.000140323342762496 DCN/SLIT2/ADGRA2/CREB3L1/EMILIN1/THBS1/BAMBI/SPRY1/TWSG1/CASK/HTRA1/SULF2/FBN1/ABL1/SKIL/SKI/CRIM1 17 GO:0010811 positive regulation of cell-substrate adhesion 18/803 123/18722 5.06736845167564e-06 0.000143556244886675 EGFL6/FBLN2/NID1/THY1/CSF1/COL16A1/EFEMP2/EMILIN1/CD36/MYADM/FLNA/RRAS/CCDC80/MDK/RIN2/ABL1/EPB41L5/MAP4K4 18 GO:2000736 regulation of stem cell differentiation 12/803 58/18722 5.16320946450933e-06 0.000145444985254483 PDGFRA/SOX5/GATA6/GATA4/PRICKLE1/YAP1/ZFP36L2/ABL1/LTBP3/N4BP2L2/JAG1/STAT3 12 GO:0045807 positive regulation of endocytosis 16/803 100/18722 5.21600088238494e-06 0.000146106631458266 VTN/CD36/GPC3/APOE/ANGPT1/CD63/LRP1/AXL/B2M/CLU/CD151/AP2B1/DAB2/WASL/MIB1/ITSN1 16 GO:0030111 regulation of Wnt signaling pathway 33/803 328/18722 5.25337835695872e-06 0.000146331533451375 COL1A1/CTHRC1/IGFBP2/ADGRA2/RSPO3/DKK3/RSPO2/MCC/BICC1/SNAI2/GPC3/APOE/BAMBI/ZEB2/PLPP3/PRICKLE1/MLLT3/PTK7/RBMS3/MDK/LRP1/APCDD1/YAP1/SULF2/ABL1/WNK1/TBL1XR1/DAB2/AMFR/FOXO3/SKI/MACF1/USP47 33 GO:0010812 negative regulation of cell-substrate adhesion 13/803 68/18722 5.32013843120059e-06 0.000147367834544256 COL1A1/APOD/THBS1/LGALS1/CASK/PTEN/LRP1/PIK3R1/DLC1/FBLN1/JAG1/MAP4K4/ACTN4 13 GO:0060317 cardiac epithelial to mesenchymal transition 9/803 32/18722 5.40974656979945e-06 0.000149022079541547 WNT2/SNAI2/SPRY1/TGFBR3/TWIST1/TGFBR2/ENG/JAG1/RTN4 9 GO:0061572 actin filament bundle organization 21/803 161/18722 5.56153744875474e-06 0.000152361679777424 SYNPO2/ELN/DPYSL3/MYO1B/LPAR1/FSCN1/PLS3/MARCKS/CALD1/FLNA/PIK3R1/ROCK2/EPS8/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/HSP90B1/CCDC88A/TJP1 21 GO:0007266 Rho protein signal transduction 19/803 137/18722 6.25610809143649e-06 0.000169526929042948 COL3A1/COL1A2/PDPN/PDGFRB/LPAR1/KANK2/APOE/HEG1/CDC42EP5/ROBO1/ARHGAP5/ROCK2/ITGB1/EPS8/DLC1/ABL1/ARHGEF12/CDC42EP3/AKAP13 19 GO:0010977 negative regulation of neuron projection development 19/803 137/18722 6.25610809143649e-06 0.000169526929042948 NR2F1/PMP22/THY1/DPYSL3/LPAR1/APOE/EFNB2/FLNA/VIM/LGALS1/SEMA3B/PTEN/LRP1/B2M/PTPRG/SEMA6D/RTN4/MAP4K4/CERS2 19 GO:0044344 cellular response to fibroblast growth factor stimulus 17/803 113/18722 6.30820827928334e-06 0.000170014737732469 COL1A1/FGF7/CREB3L1/FLRT3/SMOC2/THBS1/FGFR1/SPRY1/EXT1/ZFP36L2/SULF2/ZFP36L1/DSTYK/SETX/FRS2/NPTN/GCLM 17 GO:2000027 regulation of animal organ morphogenesis 18/803 125/18722 6.39053283516871e-06 0.000171307509226619 HGF/CTHRC1/FGF7/WNT2/RSPO3/CSF1/RSPO2/BMP4/GPC3/PRICKLE1/SPRY1/MLLT3/PTK7/ROBO1/ABL1/DAB2/FRS2/DAAM1 18 GO:0010634 positive regulation of epithelial cell migration 22/803 176/18722 6.75714353666555e-06 0.000180166404672805 FGF7/ENPP2/ADGRA2/SMOC2/BMP4/SPARC/THBS1/FGFR1/ANGPT1/PRKCA/PLPP3/RRAS/NRP2/RIN2/ROCK2/TGFBR2/BMPR2/ABL1/RTN4/EPB41L5/MAP4K4/HSPB1 22 GO:0060425 lung morphogenesis 11/803 50/18722 6.80370734093628e-06 0.00018044300426547 TCF21/FGF7/WNT2/RSPO2/BMP4/SPRY1/RDH10/NFIB/EXT1/TGFBR2/YAP1 11 GO:0034110 regulation of homotypic cell-cell adhesion 9/803 33/18722 7.15683779404225e-06 0.000188804197042829 PDPN/PRKG1/SERPINE2/PRKCA/IL6ST/LGALS1/CD9/PLAUR/JAK1 9 GO:0031102 neuron projection regeneration 12/803 60/18722 7.48816336022008e-06 0.000196505171126617 HGF/APOD/THY1/MAP1B/FLNA/PTEN/LAMB2/LRP1/TSPO/KLF4/MAP4K4/CERS2 12 GO:0032964 collagen biosynthetic process 11/803 51/18722 8.34162107431044e-06 0.000217755616107392 COL1A1/COL5A1/CREB3L1/PDGFRB/EMILIN1/BMP4/VIM/SERPINH1/TRAM2/ENG/P3H4 11 GO:0033002 muscle cell proliferation 27/803 248/18722 8.94890639522021e-06 0.000231504573129069 IGFBP3/APOD/WNT2/MMP2/IGFBP5/ELN/PDGFRB/EFEMP2/TBX2/PRKG1/GATA6/VIPR2/BMP4/THBS1/APOE/ANGPT1/GJA1/ADAMTS1/TGFBR3/PTEN/TGFBR2/YAP1/KLF4/BMPR2/PRKAR1A/TPM1/STAT3 27 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 18/803 128/18722 8.96116779260134e-06 0.000231504573129069 LTBP4/DKK3/EMILIN1/VASN/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TGFBR3/HTRA1/ENG/SPRED1/FBN1/SKIL/DAB2/SKI 18 GO:0110053 regulation of actin filament organization 29/803 277/18722 9.04468739019423e-06 0.000232457790347982 SLIT2/SYNPO2/ELN/PLEKHH2/LMOD1/LPAR1/BIN1/CDC42EP5/MYADM/FLNA/SPTBN1/CFL2/PIK3R1/ROCK2/ABI2/EPS8/SORBS3/DLC1/NCKAP1/ABL1/ARHGAP28/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/TJP1/CDC42EP3 29 GO:0007265 Ras protein signal transduction 33/803 337/18722 9.31172957595324e-06 0.000237461549917834 COL3A1/COL1A2/PDPN/CSF1/KITLG/PDGFRB/LPAR1/KANK2/APOE/HEG1/CDC42EP5/SPRY1/RRAS/ROBO1/ARHGAP5/FBXO8/ROCK2/RAP2A/ITGB1/ABI2/EPS8/RAP2B/NOTCH2/DLC1/NCKAP1/ABL1/TIMP2/PSD3/MAP4K4/ARHGEF12/SOS1/CDC42EP3/AKAP13 33 GO:0003018 vascular process in circulatory system 28/803 263/18722 9.3822553818318e-06 0.000237461549917834 SLIT2/SLC22A3/PDE3A/PRKG1/CD36/AKAP12/ITGA1/EDNRB/ACTA2/APOE/ANGPT1/KCNMA1/GJA1/SOD3/SLC2A10/ECE1/SLC16A7/EXT1/LRP1/ROCK2/BMPR2/SLC5A3/PLEC/SLC38A2/SLC8A1/ZDHHC21/TJP1/GCLM 28 GO:0043588 skin development 28/803 263/18722 9.3822553818318e-06 0.000237461549917834 COL3A1/COL1A1/COL1A2/FGF7/COL5A1/IGFBP5/FST/ADAMTS2/GATA6/LDB2/COL5A2/PPL/SLC2A10/CLDN1/PALLD/EXT1/PKD1/APCDD1/ROCK2/YAP1/TXNIP/ZFP36L1/PLEC/FOSL2/ASH1L/JAG1/ZDHHC21/SOS1 28 GO:0033627 cell adhesion mediated by integrin 13/803 72/18722 1.02659959537664e-05 0.000257670031293339 ITGBL1/VTN/COL16A1/SNAI2/PLPP3/PLAU/PIEZO1/EXT1/PDE3B/DPP4/ITGB1/FBN1/WNK1 13 GO:0022407 regulation of cell-cell adhesion 40/803 448/18722 1.02840626208132e-05 0.000257670031293339 PDPN/IGFBP2/VCAM1/THY1/PRKG1/BMP4/SERPINE2/PRKCA/PLPP3/IL6ST/MYADM/MYO10/TWSG1/IGF2/LGALS1/CD9/HLA-A/CD81/PIEZO1/GPNMB/MDK/DPP4/B2M/NFAT5/PRNP/PAG1/TGFBR2/KLF4/MAP3K8/PLAUR/PRKAR1A/ABL1/WNK1/JAG1/EPB41L5/ZMIZ1/ZDHHC21/TJP1/NDFIP1/JAK1 40 GO:0010171 body morphogenesis 10/803 43/18722 1.05361959684898e-05 0.00026266736549445 COL1A1/PDGFRA/MMP2/CRISPLD2/PHLDB1/GPC3/RRAS/ZNF281/ARID5B/SKI 10 GO:0061437 renal system vasculature development 8/803 27/18722 1.18699656552959e-05 0.000292935135974838 TCF21/PDGFRA/PDGFRB/BMP4/ACTA2/ANGPT1/PKD2/NOTCH2 8 GO:0061440 kidney vasculature development 8/803 27/18722 1.18699656552959e-05 0.000292935135974838 TCF21/PDGFRA/PDGFRB/BMP4/ACTA2/ANGPT1/PKD2/NOTCH2 8 GO:0031214 biomineral tissue development 21/803 169/18722 1.19265608910734e-05 0.000292935135974838 COL1A1/COL1A2/ENPP1/MGP/DDR2/ECM1/RSPO2/GAS6/BMP4/GPC3/OSR2/ACVR2A/FAM20C/GPNMB/ROCK2/TWIST1/BMPR2/LTBP3/SBDS/SLC8A1/NBR1 21 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 18/803 131/18722 1.24238742131986e-05 0.000303654102093176 LTBP4/DKK3/EMILIN1/VASN/THBS1/LDLRAD4/BAMBI/ZEB2/SLC2A10/SPRY1/TGFBR3/HTRA1/ENG/SPRED1/FBN1/SKIL/DAB2/SKI 18 GO:0032526 response to retinoic acid 16/803 107/18722 1.27040764318508e-05 0.00030898792726443 COL1A1/WNT2/IGFBP2/HSD17B2/PDGFRB/GATA6/EPHA3/GJA1/SERPINF1/PTK7/YAP1/KLF4/IGF2R/SETX/ATM/NCOA1 16 GO:0030282 bone mineralization 17/803 119/18722 1.27836604843426e-05 0.000309414229004526 COL1A2/ENPP1/MGP/DDR2/ECM1/RSPO2/BMP4/GPC3/OSR2/ACVR2A/GPNMB/TWIST1/BMPR2/LTBP3/SBDS/SLC8A1/NBR1 17 GO:0060828 regulation of canonical Wnt signaling pathway 27/803 253/18722 1.29038377845202e-05 0.000310814179679313 COL1A1/CTHRC1/IGFBP2/ADGRA2/RSPO3/DKK3/RSPO2/MCC/BICC1/SNAI2/GPC3/APOE/BAMBI/ZEB2/PRICKLE1/MLLT3/PTK7/RBMS3/MDK/YAP1/SULF2/WNK1/TBL1XR1/DAB2/AMFR/FOXO3/USP47 27 GO:0055001 muscle cell development 22/803 184/18722 1.3836798774511e-05 0.000331684032162075 PDGFRA/SORBS2/PDGFRB/EFEMP2/GATA4/LMOD1/BMP4/BIN1/NEBL/CFL2/SGCB/PDLIM5/ENG/ITGB1/SDC1/PRKAR1A/PLEC/TPM1/SKI/SLC8A1/AKAP13/ACTN4 22 GO:1901653 cellular response to peptide 34/803 359/18722 1.39326312510244e-05 0.00033238325080195 ENPP1/RARRES2/VCAM1/MAP1B/CD36/GJA1/IGF2/VIM/IRS1/PTEN/PDK4/PDE3B/LRP1/ZNF106/PIK3R1/SOCS2/SESN3/ROCK2/PRNP/SOCS3/ZFP36L1/RHOQ/KLF4/FBN1/PTPRA/LPIN1/PID1/FOXO3/STAT3/PRKAA1/FER/MYO1C/EIF4EBP2/NUCKS1 34 GO:0060021 roof of mouth development 14/803 85/18722 1.42562478024506e-05 0.000335436382105625 TCF21/PDGFRA/HAND2/MSC/TBX2/OSR2/TSHZ1/TGFBR3/BNC2/TWIST1/TGFBR2/ARID5B/SKI/SOS1 14 GO:0071774 response to fibroblast growth factor 17/803 120/18722 1.43091286705011e-05 0.000335436382105625 COL1A1/FGF7/CREB3L1/FLRT3/SMOC2/THBS1/FGFR1/SPRY1/EXT1/ZFP36L2/SULF2/ZFP36L1/DSTYK/SETX/FRS2/NPTN/GCLM 17 GO:0110148 biomineralization 21/803 171/18722 1.43101586015641e-05 0.000335436382105625 COL1A1/COL1A2/ENPP1/MGP/DDR2/ECM1/RSPO2/GAS6/BMP4/GPC3/OSR2/ACVR2A/FAM20C/GPNMB/ROCK2/TWIST1/BMPR2/LTBP3/SBDS/SLC8A1/NBR1 21 GO:0034446 substrate adhesion-dependent cell spreading 16/803 108/18722 1.43297130743077e-05 0.000335436382105625 PDPN/ANTXR1/LAMC3/PEAK1/MYADM/LAMC1/FLNA/LAMB2/MDK/AXL/PIK3R1/LAMB1/ABL1/FBLN1/FER/ACTN4 16 GO:0090596 sensory organ morphogenesis 27/803 256/18722 1.5982193539844e-05 0.000372370172848888 CTHRC1/WNT2/COL5A1/PITX2/THY1/COL11A1/COL8A2/TBX2/BMP4/PROM1/MFAP2/COL5A2/OSR2/TSHZ1/PTK7/TWIST1/ABI2/NOTCH2/FBN1/TUG1/JAG1/FRS2/SKI/STAT3/SP3/HIPK1/CEP290 27 GO:0035987 endodermal cell differentiation 10/803 45/18722 1.62199073083112e-05 0.000376150966694138 COL6A1/COL5A1/MMP2/VTN/COL11A1/GATA6/COL5A2/COL4A2/LAMB1/RTF1 10 GO:0031345 negative regulation of cell projection organization 22/803 186/18722 1.64288370392755e-05 0.000379232321656609 NR2F1/PMP22/SLIT2/THY1/DPYSL3/LPAR1/APOE/EFNB2/FLNA/VIM/LGALS1/SEMA3B/PTEN/LRP1/B2M/PRNP/YAP1/PTPRG/SEMA6D/RTN4/MAP4K4/CERS2 22 GO:0051056 regulation of small GTPase mediated signal transduction 30/803 302/18722 1.78301215921964e-05 0.000406208995361811 COL3A1/SLIT2/CSF1/KITLG/PDGFRB/PREX2/CHN1/LPAR1/KANK2/APOE/HEG1/SPRY1/ROBO1/ARHGAP5/PLEKHG1/FBXO8/ITGB1/EPS8/NOTCH2/DLC1/ABL1/ARHGAP28/TIMP2/PSD3/ARHGAP21/MAP4K4/ARHGEF12/SOS1/AKAP13/ITSN1 30 GO:0003177 pulmonary valve development 7/803 21/18722 1.78419113486235e-05 0.000406208995361811 SLIT2/BMP4/ROBO1/TNFRSF1A/NOTCH2/BMPR2/JAG1 7 GO:0035455 response to interferon-alpha 7/803 21/18722 1.78419113486235e-05 0.000406208995361811 GAS6/IFITM2/IFITM3/IFITM1/AXL/BST2/IFNAR1 7 GO:0006898 receptor-mediated endocytosis 26/803 244/18722 1.90720838709408e-05 0.000432242773547776 VTN/CD36/APOE/ANGPT1/RAMP1/CD9/CD81/PDLIM7/CD63/HSPG2/LRP1/B2M/CLU/LRP6/TGFBR2/ITGB1/SCARB2/AP2B1/PLA2R1/IGF2R/DAB2/WASL/VLDLR/CLTC/CANX/ITSN1 26 GO:0048009 insulin-like growth factor receptor signaling pathway 9/803 37/18722 1.97867840750407e-05 0.000446411336643227 IGFBP3/BMP5/IGFBP2/IGFBP5/IRS1/PIK3R1/PLCB1/IGF2R/CRIM1 9 GO:0060976 coronary vasculature development 10/803 46/18722 1.99359156215612e-05 0.000447749888689658 HAND2/PDGFRB/GATA6/BMP4/GPC3/PRICKLE1/TGFBR3/PTK7/SPRED1/AP2B1 10 GO:0072073 kidney epithelium development 18/803 136/18722 2.09134553913276e-05 0.000467598603502956 TCF21/SLIT2/BMP4/PROM1/GPC3/KANK2/SPRY1/MYO1E/LAMB2/EXT1/BASP1/SMAD5/PKD1/PKD2/YAP1/NOTCH2/SDC1/JAG1 18 GO:0032535 regulation of cellular component size 35/803 382/18722 2.1201607455271e-05 0.000471925065946345 SLIT2/ELN/MAP1B/PLEKHH2/LMOD1/APOE/KCNMA1/BIN1/CDC42EP5/MYADM/SPTBN1/CFL2/SEMA3B/PTEN/NRCAM/LRP1/ABI2/EPS8/BMPR2/NCKAP1/ABL1/SEMA6D/ARHGAP28/RTN4/WASL/FER/DPYSL2/MYO1C/MSN/GSN/RB1CC1/MACF1/CDC42EP3/GOLGA4/TMEM123 35 GO:0048008 platelet-derived growth factor receptor signaling pathway 11/803 56/18722 2.14467064615137e-05 0.000475259015187143 APOD/PDGFRA/F3/PDGFRB/MYO1E/PTEN/LRP1/TXNIP/ABL1/ARID5B/FER 11 GO:0045861 negative regulation of proteolysis 33/803 351/18722 2.15571975444401e-05 0.00047559374759548 HGF/COL6A3/WFDC1/PROS1/ECM1/VTN/GAS6/SERPINE2/GPC3/THBS1/CRYAB/CAMK2N1/TMEM98/TIMP1/BIN1/GAS1/SERPING1/SERPINF1/TIMP3/LRP1/TFPI/A2M/SERPINH1/PRNP/BST2/KLF4/PLAUR/TIMP2/TMEM59/IFI16/SERPINB9/CRIM1/USP47 33 GO:0035850 epithelial cell differentiation involved in kidney development 10/803 47/18722 2.43596525850711e-05 0.000532857874536114 BMP4/PROM1/ACTA2/MYO1E/LAMB2/EXT1/BASP1/YAP1/NOTCH2/JAG1 10 GO:0070527 platelet aggregation 12/803 67/18722 2.43665454059835e-05 0.000532857874536114 PDGFRA/PDPN/MYL9/PRKG1/SERPINE2/PRKCA/IL6ST/FLNA/CD9/RAP2B/VCL/HSPB1 12 GO:0042326 negative regulation of phosphorylation 35/803 385/18722 2.49898981950619e-05 0.000544103198255803 IGFBP3/HGF/ENPP1/SLIT2/THY1/EMILIN1/BMP4/APOE/CAMK2N1/HEG1/LDLRAD4/ANGPT1/PLPP3/MYADM/SPRY1/PTEN/LRP1/LRP6/PRNP/TWIST1/SOCS3/NUPR1/ENG/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/PID1/HIPK3/WNK1/FBLN1/STAT3/SLC8A1/HSPB1 35 GO:0002683 negative regulation of immune system process 38/803 434/18722 2.63016848355678e-05 0.000570174785174527 COL3A1/APOD/BMP5/SLIT2/THY1/KITLG/EMILIN1/BMP4/TMEM176A/THBS1/ANGPT1/TMEM176B/TWSG1/HLA-B/SERPING1/HLA-A/HTRA1/GPNMB/MDK/AXL/DPP4/A2M/PIK3R1/PRNP/PLCB1/PAG1/BST2/FBN1/PRKAR1A/GPR137B/HLA-F/WASL/FER/IFI16/SERPINB9/ATM/NDFIP1/TSPAN6 38 GO:0007568 aging 32/803 339/18722 2.64307476545876e-05 0.000570492241583436 DCN/APOD/IGFBP2/VCAM1/IGFBP5/PDGFRB/TBX2/CRYAB/EDNRB/TIMP1/COL4A2/CLDN1/SERPING1/SERPINF1/PTEN/LRP1/B2M/TSPO/PRNP/TWIST1/TGFBR2/ABL1/TIMP2/PLA2R1/LITAF/AMFR/FOXO3/STAT3/ZMIZ1/GCLM/ATM/CANX 32 GO:0030177 positive regulation of Wnt signaling pathway 18/803 140/18722 3.10924473471057e-05 0.000668219579623574 COL1A1/ADGRA2/RSPO3/RSPO2/GPC3/BAMBI/ZEB2/MLLT3/PTK7/YAP1/SULF2/ABL1/WNK1/TBL1XR1/DAB2/SKI/MACF1/USP47 18 GO:0001933 negative regulation of protein phosphorylation 32/803 342/18722 3.14380603641711e-05 0.000670341215068377 IGFBP3/HGF/ENPP1/SLIT2/THY1/EMILIN1/BMP4/APOE/CAMK2N1/HEG1/LDLRAD4/ANGPT1/PLPP3/MYADM/SPRY1/PTEN/LRP1/LRP6/PRNP/TWIST1/SOCS3/ENG/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/PID1/HIPK3/FBLN1/SLC8A1/HSPB1 32 GO:0014033 neural crest cell differentiation 14/803 91/18722 3.15945017130101e-05 0.000670341215068377 PITX2/HAND2/KITLG/SNAI2/BMP4/EDNRB/RDH10/SEMA3B/EXT1/NRP2/LRP6/TWIST1/SEMA6D/JAG1 14 GO:0055006 cardiac cell development 14/803 91/18722 3.15945017130101e-05 0.000670341215068377 PDGFRA/SORBS2/PDGFRB/GATA4/BMP4/SPRY1/NEBL/TGFBR3/SGCB/PDLIM5/PLEC/JAG1/SLC8A1/AKAP13 14 GO:1901654 response to ketone 22/803 194/18722 3.17524963916369e-05 0.000670838758511448 SLIT2/PTGFR/FIBIN/SLIT3/GAS6/ADCY3/THBS1/PTGER2/CLDN1/TGFBR3/SERPINF1/GNAI1/NR3C1/TSPO/ROCK2/YAP1/TXNIP/KLF4/FOXO3/PRKAA1/MSN/NCOA1 22 GO:0045669 positive regulation of osteoblast differentiation 12/803 69/18722 3.31104603809996e-05 0.000693545431144203 HGF/CTHRC1/DDR2/BMP4/IL6ST/ACVR2A/IFITM1/PDLIM7/SMAD5/YAP1/BMPR2/JAG1 12 GO:0001570 vasculogenesis 13/803 80/18722 3.326383906222e-05 0.000693545431144203 PDGFRB/HOXA13/HEG1/MYO1E/TGFBR3/RRAS/RIN2/TGFBR2/YAP1/ENG/ZFP36L1/SPRED1/ZMIZ1 13 GO:0071229 cellular response to acid chemical 13/803 80/18722 3.326383906222e-05 0.000693545431144203 COL1A1/COL1A2/COL6A1/PDGFRA/MMP2/COL16A1/COL5A2/COL4A1/PKD2/SESN3/CAPN2/PLEC/GCLM 13 GO:0010951 negative regulation of endopeptidase activity 26/803 252/18722 3.33836549287222e-05 0.000693545431144203 HGF/COL6A3/WFDC1/PROS1/VTN/GAS6/SERPINE2/THBS1/CRYAB/TIMP1/BIN1/SERPING1/SERPINF1/TIMP3/TFPI/A2M/SERPINH1/PRNP/BST2/KLF4/PLAUR/TIMP2/IFI16/SERPINB9/CRIM1/USP47 26 GO:0008286 insulin receptor signaling pathway 16/803 116/18722 3.55528532068666e-05 0.000735545751408452 ENPP1/RARRES2/IGF2/IRS1/PDK4/ZNF106/PIK3R1/SESN3/SOCS3/RHOQ/PTPRA/PID1/PRKAA1/FER/EIF4EBP2/NUCKS1 16 GO:0038084 vascular endothelial growth factor signaling pathway 10/803 49/18722 3.57731148865225e-05 0.000737044424893394 DCN/PDGFRA/ADGRA2/PDGFRB/SMOC2/ROBO1/CD63/NRP2/MYO1C/HSPB1 10 GO:0071711 basement membrane organization 8/803 31/18722 3.62145908915896e-05 0.000743069753849654 NID1/PHLDB1/NID2/COL4A1/LAMB2/EXT1/ITGB1/LAMB1 8 GO:0060419 heart growth 15/803 104/18722 3.64286974183977e-05 0.000744399530033323 WNT2/SORBS2/TBX2/GATA6/GATA4/HEG1/GJA1/TGFBR3/PTEN/BASP1/PDLIM5/TGFBR2/YAP1/PRKAR1A/AKAP13 15 GO:0070371 ERK1 and ERK2 cascade 31/803 330/18722 3.85720856356135e-05 0.000784981301955792 PDGFRA/PLA2G2A/HAND2/PDGFRB/EMILIN1/GATA4/GAS6/CD36/AKAP12/BMP4/APOE/CAMK2N1/ANGPT1/PRKCA/SPRY1/MFHAS1/PTEN/RRAS/GPNMB/TIMP3/LRP1/ZFP36L2/ZFP36L1/SPRED1/NOTCH2/KLF4/ABL1/DSTYK/FBLN1/FRS2/NPTN 31 GO:0042476 odontogenesis 17/803 130/18722 4.11554638973542e-05 0.000834150987773203 COL1A1/COL1A2/PDGFRA/PITX2/ADAMTS5/HAND2/FST/CSF1/RSPO2/BMP4/OSR2/ACVR2A/HTRA1/FAM20C/TWIST1/LAMB1/SDC1 17 GO:0001892 embryonic placenta development 13/803 82/18722 4.35158118944493e-05 0.000874878379458566 BMP5/WNT2/RSPO3/IGF2/PKD1/EPAS1/PKD2/SOCS3/ZFP36L1/SP3/HECTD1/BPTF/NCOA1 13 GO:0008543 fibroblast growth factor receptor signaling pathway 13/803 82/18722 4.35158118944493e-05 0.000874878379458566 FGF7/CREB3L1/FLRT3/SMOC2/THBS1/FGFR1/SPRY1/EXT1/SULF2/DSTYK/SETX/FRS2/NPTN 13 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 17/803 131/18722 4.54399992011316e-05 0.000909894923762418 FST/EMILIN1/VASN/LDLRAD4/BAMBI/SLC2A10/SPRY1/TWSG1/TGFBR3/HTRA1/LRP1/SPRED1/FBN1/ABL1/SKIL/SKI/CRIM1 17 GO:0001953 negative regulation of cell-matrix adhesion 9/803 41/18722 4.77740000973617e-05 0.00094900862344799 APOD/THBS1/CASK/PTEN/LRP1/PIK3R1/DLC1/JAG1/MAP4K4 9 GO:1905521 regulation of macrophage migration 9/803 41/18722 4.77740000973617e-05 0.00094900862344799 RARRES2/CSF1/EMILIN1/THBS1/CMKLR1/CD9/CD81/MDK/MTUS1 9 GO:0043434 response to peptide hormone 36/803 414/18722 4.91675318872643e-05 0.000972814738055157 COL1A1/ENPP1/RARRES2/IGFBP5/MAP1B/SPARC/EDNRB/TIMP1/GJA1/IGF2/TGFBR3/IRS1/PTEN/PDK4/PDE3B/GNAI1/ZNF106/PIK3R1/SOCS2/SESN3/ROCK2/LRP6/SOCS3/ZFP36L1/RHOQ/FBN1/PTPRA/LPIN1/PID1/STAT3/PRKAA1/FER/MYO1C/EIF4EBP2/SORT1/NUCKS1 36 GO:0010715 regulation of extracellular matrix disassembly 6/803 17/18722 5.03536783622052e-05 0.000992345613889151 PDPN/FAP/DDR2/FSCN1/LRP1/DPP4 6 GO:0007229 integrin-mediated signaling pathway 15/803 107/18722 5.11066476238994e-05 0.000999047241352944 COL3A1/ITGBL1/THY1/COL16A1/ITGA1/TIMP1/ADAMTS1/PLPP3/SLC2A10/FLNA/DST/CD63/ITGB1/PTPRA/ABL1 15 GO:0031532 actin cytoskeleton reorganization 15/803 107/18722 5.11066476238994e-05 0.000999047241352944 PDGFRA/FGF7/ANTXR1/FLNA/PTK7/MDK/CDC42BPA/RAP2A/EPS8/NOTCH2/ABL1/PLEC/FER/GSN/TJP1 15 GO:1903036 positive regulation of response to wounding 12/803 72/18722 5.12948443213706e-05 0.000999047241352944 F3/VTN/SMOC2/CD36/THBS1/MYLK/PLPP3/FLNA/CLDN1/MDK/LRP1/ITGB1 12 GO:0032836 glomerular basement membrane development 5/803 11/18722 5.33642813642679e-05 0.00103530858709043 NID1/MYO1E/LAMB2/EXT1/SULF2 5 GO:0002088 lens development in camera-type eye 13/803 84/18722 5.64156282430791e-05 0.00108605529891889 WNT2/BMP4/CRYAB/MAF/SPRY1/VIM/TGFBR2/ABI2/SPRED1/SKIL/FRS2/SKI/HIPK1 13 GO:0045445 myoblast differentiation 13/803 84/18722 5.64156282430791e-05 0.00108605529891889 IGFBP3/TBX2/PITX1/BMP4/PRICKLE1/LGALS1/EPAS1/PLCB1/ZFP36L1/SDC1/DDX17/PLEC/JAG1 13 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 11/803 62/18722 5.79161514458857e-05 0.00110921428205061 BMP5/EMILIN1/GDF6/BMP4/LDLRAD4/TWSG1/ACVR2A/LRP1/ENG/BMPR2/DAB2 11 GO:0055017 cardiac muscle tissue growth 14/803 96/18722 5.8063563500844e-05 0.00110921428205061 WNT2/SORBS2/TBX2/GATA6/GATA4/HEG1/GJA1/TGFBR3/PTEN/PDLIM5/TGFBR2/YAP1/PRKAR1A/AKAP13 14 GO:0035924 cellular response to vascular endothelial growth factor stimulus 12/803 73/18722 5.9023768363004e-05 0.00111980637290715 DCN/PDGFRA/VCAM1/ADGRA2/PDGFRB/SMOC2/GAS1/ROBO1/CD63/NRP2/MYO1C/HSPB1 12 GO:0070570 regulation of neuron projection regeneration 8/803 33/18722 5.90672033843923e-05 0.00111980637290715 HGF/THY1/FLNA/PTEN/LRP1/KLF4/MAP4K4/CERS2 8 GO:1904019 epithelial cell apoptotic process 16/803 121/18722 5.99702094945145e-05 0.00113261918386231 CD248/GAS6/THBS1/ANGPT1/MDK/TGFBR2/YAP1/NUPR1/ZFP36L1/BMPR2/ABL1/PLA2R1/FOXO3/HIPK1/SORT1/GSN 16 GO:0010718 positive regulation of epithelial to mesenchymal transition 10/803 52/18722 6.13056009357178e-05 0.00115347066515279 COL1A1/PDPN/BMP4/BAMBI/MDK/TWIST1/TGFBR2/ENG/JAG1/DAB2 10 GO:0072012 glomerulus vasculature development 7/803 25/18722 6.34669881675644e-05 0.00118519252061227 TCF21/PDGFRA/PDGFRB/BMP4/ACTA2/ANGPT1/NOTCH2 7 GO:1903055 positive regulation of extracellular matrix organization 7/803 25/18722 6.34669881675644e-05 0.00118519252061227 PDPN/DDR2/EFEMP2/EMILIN1/PHLDB1/FSCN1/COLGALT1 7 GO:0032092 positive regulation of protein binding 13/803 85/18722 6.4027738600415e-05 0.00119120262933459 CTHRC1/SPON1/VTN/BMP4/APOE/BAMBI/RAMP1/PKD1/LRP1/B2M/ABL1/AMFR/EPB41L5 13 GO:0070167 regulation of biomineral tissue development 14/803 97/18722 6.52245315707398e-05 0.00120895730264576 ENPP1/MGP/DDR2/ECM1/GAS6/BMP4/OSR2/ACVR2A/ROCK2/TWIST1/BMPR2/LTBP3/SLC8A1/NBR1 14 GO:0022617 extracellular matrix disassembly 11/803 63/18722 6.74834618352035e-05 0.00124619459522342 PDPN/MMP2/ADAMTS5/FAP/DDR2/ADAMTS15/CTSK/FSCN1/LAMC1/LRP1/DPP4 11 GO:0070372 regulation of ERK1 and ERK2 cascade 29/803 309/18722 6.90279434785375e-05 0.00127001227374165 PDGFRA/PLA2G2A/HAND2/PDGFRB/EMILIN1/GATA4/GAS6/CD36/AKAP12/BMP4/APOE/CAMK2N1/ANGPT1/PRKCA/SPRY1/MFHAS1/PTEN/RRAS/GPNMB/TIMP3/LRP1/SPRED1/NOTCH2/KLF4/ABL1/DSTYK/FBLN1/FRS2/NPTN 29 GO:0060348 bone development 22/803 205/18722 7.34471869252554e-05 0.00134635174268134 COL1A1/STC1/PITX2/BMP4/GJA1/OSR2/PLS3/RAB23/EXT1/SMAD5/SERPINH1/TWIST1/TGFBR2/SULF2/ENG/NOTCH2/FBN1/BMPR2/LTBP3/SBDS/SKI/AKAP13 22 GO:0035909 aorta morphogenesis 8/803 34/18722 7.43601825020751e-05 0.0013580947617412 PDGFRB/EFEMP2/TBX2/MYLK/FKBP10/LRP1/ENG/JAG1 8 GO:0048705 skeletal system morphogenesis 23/803 220/18722 7.61750912881102e-05 0.00138616425241795 COL1A1/PDGFRA/MMP2/MGP/STC1/COL11A1/SOX5/BMP4/FGFR1/OSR2/THRA/RDH10/RAB23/EXT1/PKD1/SERPINH1/TWIST1/TGFBR2/BMPR2/BMP1/LTBP3/ARID5B/SKI 23 GO:0055002 striated muscle cell development 11/803 64/18722 7.83732094988166e-05 0.00142097753658582 PDGFRA/PDGFRB/LMOD1/NEBL/CFL2/ITGB1/SDC1/PRKAR1A/PLEC/TPM1/AKAP13 11 GO:0110149 regulation of biomineralization 14/803 99/18722 8.18866862582411e-05 0.00147804286537235 ENPP1/MGP/DDR2/ECM1/GAS6/BMP4/OSR2/ACVR2A/ROCK2/TWIST1/BMPR2/LTBP3/SLC8A1/NBR1 14 GO:0045936 negative regulation of phosphate metabolic process 37/803 441/18722 8.21134925206859e-05 0.00147804286537235 IGFBP3/HGF/ENPP1/SLIT2/THY1/EMILIN1/BMP4/APOE/CAMK2N1/HEG1/LDLRAD4/ANGPT1/PLPP3/MYADM/SPRY1/MFHAS1/PTEN/LRP1/ROCK2/LRP6/PRNP/TWIST1/SOCS3/NUPR1/ENG/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/PID1/HIPK3/WNK1/FBLN1/STAT3/SLC8A1/HSPB1 37 GO:0050679 positive regulation of epithelial cell proliferation 22/803 207/18722 8.48822159186126e-05 0.00151656763627155 BMP5/FGF7/F3/WNT2/ECM1/BMP4/FGFR1/OSR2/PRKCA/LAMC1/CLDN1/IGF2/HTRA1/MDK/NRP2/TWIST1/YAP1/NOTCH2/LAMB1/BMPR2/RTN4/STAT3 22 GO:0048754 branching morphogenesis of an epithelial tube 18/803 151/18722 8.51662531399989e-05 0.00151656763627155 TCF21/WNT2/SLIT2/CSF1/RSPO2/BMP4/GPC3/COL4A1/SPRY1/RDH10/EXT1/PKD1/MDK/PKD2/TGFBR2/YAP1/ENG/ABL1 18 GO:0071456 cellular response to hypoxia 18/803 151/18722 8.51662531399989e-05 0.00151656763627155 STC1/GATA6/VASN/PTEN/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/NDRG1/MALAT1/ZFP36L1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 18 GO:0001706 endoderm formation 10/803 54/18722 8.58242375155788e-05 0.00152117392833503 COL6A1/COL5A1/MMP2/VTN/COL11A1/GATA6/COL5A2/COL4A2/LAMB1/RTF1 10 GO:0010563 negative regulation of phosphorus metabolic process 37/803 442/18722 8.60351078601039e-05 0.00152117392833503 IGFBP3/HGF/ENPP1/SLIT2/THY1/EMILIN1/BMP4/APOE/CAMK2N1/HEG1/LDLRAD4/ANGPT1/PLPP3/MYADM/SPRY1/MFHAS1/PTEN/LRP1/ROCK2/LRP6/PRNP/TWIST1/SOCS3/NUPR1/ENG/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/PID1/HIPK3/WNK1/FBLN1/STAT3/SLC8A1/HSPB1 37 GO:0061307 cardiac neural crest cell differentiation involved in heart development 5/803 12/18722 8.82513852812988e-05 0.00154393476144756 PITX2/HAND2/BMP4/TWIST1/JAG1 5 GO:0061308 cardiac neural crest cell development involved in heart development 5/803 12/18722 8.82513852812988e-05 0.00154393476144756 PITX2/HAND2/BMP4/TWIST1/JAG1 5 GO:0072015 glomerular visceral epithelial cell development 5/803 12/18722 8.82513852812988e-05 0.00154393476144756 BMP4/MYO1E/LAMB2/NOTCH2/JAG1 5 GO:0010837 regulation of keratinocyte proliferation 8/803 35/18722 9.27987672980069e-05 0.00160657865884674 FGF7/SNAI2/CASK/MDK/PTPRK/YAP1/ZFP36L1/NOTCH2 8 GO:0035633 maintenance of blood-brain barrier 8/803 35/18722 9.27987672980069e-05 0.00160657865884674 LAMA2/ANGPT1/GJA1/LAMC1/CLDN1/ITGB1/VCL/TJP1 8 GO:0050654 chondroitin sulfate proteoglycan metabolic process 8/803 35/18722 9.27987672980069e-05 0.00160657865884674 DCN/CYTL1/CSGALNACT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2 8 GO:1905517 macrophage migration 10/803 55/18722 0.000100913832846898 0.00174102550371845 RARRES2/CSF1/EMILIN1/THBS1/EDNRB/CMKLR1/CD9/CD81/MDK/MTUS1 10 GO:0002685 regulation of leukocyte migration 22/803 210/18722 0.000105011780875476 0.00180547841187973 APOD/BMP5/RARRES2/SLIT2/THY1/ECM1/CSF1/KITLG/EMILIN1/GAS6/THBS1/IL1R1/CMKLR1/CD9/CD81/MDK/DPP4/PLCB1/WNK1/WASL/MSN/MTUS1 22 GO:0043410 positive regulation of MAPK cascade 39/803 480/18722 0.000105637219376101 0.00180999029487711 HGF/PDGFRA/PLA2G2A/HAND2/KITLG/PDGFRB/GDF6/GATA4/GAS6/CD36/AKAP12/BMP4/THBS1/LPAR1/APOE/FGFR1/ANGPT1/PRKCA/IGF2/MFHAS1/CD81/PTEN/GPNMB/ROBO1/LRP1/ROCK2/PLCB1/SORBS3/NOTCH2/ABL1/TAOK1/TIMP2/DSTYK/FRS2/NPTN/PJA2/RB1CC1/AKAP13/LTBR 39 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 15/803 114/18722 0.000106985762511117 0.00182681853383709 BMP5/GDF6/GATA4/BMP4/GPC3/THBS1/ZEB2/SLC2A10/TWSG1/ACVR2A/TGFBR3/ENG/NOTCH2/BMPR2/DAB2 15 GO:0030500 regulation of bone mineralization 12/803 78/18722 0.000114610926390842 0.00195034156650082 ENPP1/MGP/DDR2/ECM1/BMP4/OSR2/ACVR2A/TWIST1/BMPR2/LTBP3/SLC8A1/NBR1 12 GO:0043616 keratinocyte proliferation 9/803 46/18722 0.000123988449035304 0.00209561493861026 FGF7/FST/SNAI2/CASK/MDK/PTPRK/YAP1/ZFP36L1/NOTCH2 9 GO:0061028 establishment of endothelial barrier 9/803 46/18722 0.000123988449035304 0.00209561493861026 MYADM/CLDN1/ROCK2/PLCB1/TNFRSF1A/VCL/MSN/ZDHHC21/TJP1 9 GO:0006029 proteoglycan metabolic process 12/803 79/18722 0.000129947828197706 0.00218891848443838 DCN/CYTL1/COL11A1/CSGALNACT1/DSEL/CSGALNACT2/SLC2A10/EXT1/UGDH/SULF2/BMPR2/CHPF2 12 GO:0050900 leukocyte migration 32/803 369/18722 0.000133483316766945 0.00224090174208751 APOD/BMP5/RARRES2/VCAM1/SLIT2/THY1/ECM1/CSF1/KITLG/EMILIN1/GAS6/ITGA1/THBS1/EDNRB/IL1R1/CMKLR1/CD9/CD81/EXT1/MDK/DPP4/PLCB1/ITGB1/EPS8/PLEC/WNK1/SBDS/WASL/FER/MSN/MTUS1/SOS1 32 GO:0002011 morphogenesis of an epithelial sheet 10/803 57/18722 0.00013789836093161 0.002276612321733 BMP5/PDPN/COL5A1/FLRT3/FLNA/PTEN/NOTCH2/CD151/JAG1/SOS1 10 GO:0034112 positive regulation of homotypic cell-cell adhesion 5/803 13/18722 0.000138350086940453 0.002276612321733 PDPN/IL6ST/LGALS1/PLAUR/JAK1 5 GO:0042308 negative regulation of protein import into nucleus 5/803 13/18722 0.000138350086940453 0.002276612321733 APOD/CD36/ANGPT1/RAB23/PKIG 5 GO:0072310 glomerular epithelial cell development 5/803 13/18722 0.000138350086940453 0.002276612321733 BMP4/MYO1E/LAMB2/NOTCH2/JAG1 5 GO:1903054 negative regulation of extracellular matrix organization 5/803 13/18722 0.000138350086940453 0.002276612321733 FAP/ANTXR1/EMILIN1/DPP4/TNFRSF1A 5 GO:1904590 negative regulation of protein import 5/803 13/18722 0.000138350086940453 0.002276612321733 APOD/CD36/ANGPT1/RAB23/PKIG 5 GO:0060325 face morphogenesis 7/803 28/18722 0.000139703088341656 0.00229131446865623 COL1A1/PDGFRA/MMP2/CRISPLD2/RRAS/ARID5B/SKI 7 GO:0060428 lung epithelium development 8/803 37/18722 0.000141095334440309 0.00230656176235862 FGF7/WNT2/GATA6/BMP4/THRA/NFIB/PKD1/YAP1 8 GO:1903828 negative regulation of cellular protein localization 15/803 117/18722 0.000143906713381379 0.00234483291803776 APOD/CD36/TMEM98/ANGPT1/MFHAS1/RAB23/ROCK2/RHOQ/PKIG/PID1/DAB2/TMEM59/CLTC/HECTD1/TERF1 15 GO:0007422 peripheral nervous system development 12/803 80/18722 0.00014700970863338 0.00237983898456503 LAMA2/PMP22/HAND2/NFASC/EDNRB/CLDN1/LAMB2/NDRG1/SLC5A3/PLEC/SKI/GSTM3 12 GO:0009791 post-embryonic development 12/803 80/18722 0.00014700970863338 0.00237983898456503 NDN/BMP4/MFAP2/HEG1/MYO1E/KLF4/FBN1/ABL1/ASH1L/IGF2R/ATRX/ARID5B 12 GO:0010712 regulation of collagen metabolic process 9/803 47/18722 0.000147584742931413 0.00238141594904862 MFAP4/FAP/CREB3L1/PDGFRB/EMILIN1/BMP4/VIM/ENG/ITGB1 9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 20/803 186/18722 0.000149713873329889 0.0024079786207188 ECM1/CD36/LPAR1/GJA1/CXXC5/FLNA/LGALS1/MTDH/S100A4/TIFA/BST2/TNFRSF1A/GOLT1B/ABL1/LITAF/MIER1/AKAP13/LTBR/NDFIP1/TSPAN6 20 GO:0022612 gland morphogenesis 15/803 118/18722 0.000158457075266107 0.00254040828706369 HGF/FGF7/IGFBP5/CSF1/TBX2/HOXA13/BMP4/TWSG1/NFIB/MDK/TGFBR2/SULF2/NOTCH2/FRS2/MSN 15 GO:0001954 positive regulation of cell-matrix adhesion 10/803 58/18722 0.000160308513840631 0.00256185336541469 THY1/CSF1/COL16A1/EFEMP2/CD36/RRAS/RIN2/ABL1/EPB41L5/MAP4K4 10 GO:0051099 positive regulation of binding 19/803 173/18722 0.000164680846054288 0.00262331852532485 CTHRC1/SPON1/HAND2/VTN/BMP4/APOE/BAMBI/RAMP1/ZNF618/PKD1/LRP1/B2M/TWIST1/KLF4/PLAUR/ABL1/AMFR/EPB41L5/SKI 19 GO:0014032 neural crest cell development 12/803 81/18722 0.000165952232226339 0.00262385929565732 PITX2/HAND2/KITLG/SNAI2/BMP4/EDNRB/RDH10/SEMA3B/NRP2/TWIST1/SEMA6D/JAG1 12 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 12/803 81/18722 0.000165952232226339 0.00262385929565732 EMILIN1/VASN/LDLRAD4/BAMBI/SLC2A10/SPRY1/TGFBR3/HTRA1/SPRED1/FBN1/SKIL/SKI 12 GO:0022604 regulation of cell morphogenesis 28/803 309/18722 0.000166293529367772 0.00262385929565732 PDPN/ENPP2/PTPRD/PALM/SPARC/LPAR1/FBLIM1/BAMBI/CDC42EP5/MYADM/MYO10/FLNA/RND3/MDK/FMNL2/EPS8/RHOQ/DLC1/ABL1/PDZD8/TPM1/FBLN1/ZMYM4/PLXNB2/MSN/MACF1/CDC42EP3/ACTN4 28 GO:0010594 regulation of endothelial cell migration 23/803 232/18722 0.000169744999165832 0.0026698692928733 DCN/STC1/SLIT2/ADGRA2/SMOC2/BMP4/SPARC/THBS1/APOE/FGFR1/ANGPT1/PRKCA/PLPP3/SERPINF1/RRAS/NRP2/RIN2/ROCK2/SPRED1/KLF4/BMPR2/ABL1/HSPB1 23 GO:0003209 cardiac atrium morphogenesis 7/803 29/18722 0.000177388388073848 0.0027725971878878 WNT2/GATA4/HEG1/ENG/NOTCH2/BMPR2/SOS1 7 GO:0060441 epithelial tube branching involved in lung morphogenesis 7/803 29/18722 0.000177388388073848 0.0027725971878878 WNT2/RSPO2/BMP4/SPRY1/RDH10/EXT1/YAP1 7 GO:0032869 cellular response to insulin stimulus 21/803 203/18722 0.000178410623602974 0.00277986052901384 ENPP1/RARRES2/IGF2/IRS1/PTEN/PDK4/PDE3B/ZNF106/PIK3R1/SESN3/SOCS3/ZFP36L1/RHOQ/PTPRA/LPIN1/PID1/PRKAA1/FER/MYO1C/EIF4EBP2/NUCKS1 21 GO:0046578 regulation of Ras protein signal transduction 20/803 189/18722 0.000186010661136618 0.0028832621664611 COL3A1/CSF1/KITLG/PDGFRB/LPAR1/KANK2/APOE/HEG1/SPRY1/ROBO1/FBXO8/ITGB1/EPS8/NOTCH2/DLC1/ABL1/TIMP2/PSD3/MAP4K4/AKAP13 20 GO:0010595 positive regulation of endothelial cell migration 16/803 133/18722 0.000186203453189024 0.0028832621664611 ADGRA2/SMOC2/BMP4/SPARC/THBS1/FGFR1/ANGPT1/PRKCA/PLPP3/RRAS/NRP2/RIN2/ROCK2/BMPR2/ABL1/HSPB1 16 GO:0060395 SMAD protein signal transduction 12/803 82/18722 0.000186941332854664 0.00288572596165125 BMP5/GDF6/BMP4/SLC2A10/VIM/SPTBN1/SMAD5/LRP1/BMPR2/DAB2/SKI/ZMIZ1 12 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 24/803 249/18722 0.000190142371463014 0.0029188024318469 ECM1/CD36/LPAR1/ANGPT1/GJA1/CXXC5/FLNA/LGALS1/MTDH/S100A4/TIFA/BST2/TNFRSF1A/GOLT1B/ABL1/ASH1L/LITAF/ZMYND11/MIER1/AKAP13/LTBR/NDFIP1/HSPB1/TSPAN6 24 GO:0001502 cartilage condensation 6/803 21/18722 0.000190549333989446 0.0029188024318469 MGP/COL11A1/SOX5/THRA/PKD1/BMP1 6 GO:1905475 regulation of protein localization to membrane 19/803 175/18722 0.000191424197739777 0.0029188024318469 EPHA3/GPC3/SPTBN1/CD81/LRP1/PIK3R1/PRNP/ITGB1/RHOQ/SLC5A3/AP2B1/PID1/DAB2/STOM/TMEM59/MYO1C/GSN/CLTC/HECTD1 19 GO:0048593 camera-type eye morphogenesis 15/803 120/18722 0.000191425670921367 0.0029188024318469 WNT2/PITX2/THY1/COL8A2/TBX2/BMP4/PROM1/TWIST1/ABI2/NOTCH2/JAG1/FRS2/SKI/SP3/HIPK1 15 GO:0036294 cellular response to decreased oxygen levels 18/803 161/18722 0.000193863131500354 0.00294695601725842 STC1/GATA6/VASN/PTEN/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/NDRG1/MALAT1/ZFP36L1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 18 GO:0043254 regulation of protein-containing complex assembly 35/803 427/18722 0.000198855139907834 0.00301365266741782 SLIT2/ELN/STXBP6/MAP1B/LMOD1/CD36/CRYAB/APOE/LDLRAD4/FBLIM1/FSCN1/BIN1/CDC42EP5/THRA/MYADM/SPTBN1/PIEZO1/CLU/EIF4EBP1/NIN/ABI2/EPS8/NCKAP1/ABL1/ARHGAP28/ASAP1/SAR1A/WASL/FER/MYO1C/MSN/GSN/TERF1/ATM/CDC42EP3 35 GO:0071230 cellular response to amino acid stimulus 11/803 71/18722 0.000205489752359469 0.00310451682906157 COL1A1/COL1A2/COL6A1/PDGFRA/MMP2/COL16A1/COL5A2/COL4A1/SESN3/CAPN2/GCLM 11 GO:0008038 neuron recognition 9/803 49/18722 0.000206096083116602 0.00310451682906157 NDN/EPHA3/NEXN/PALLD/NRCAM/EXT1/ROBO1/RTN4/NPTN 9 GO:0018212 peptidyl-tyrosine modification 32/803 378/18722 0.000207102983905947 0.00311028758359955 HGF/PDGFRA/FGF7/ENPP2/THY1/DDR2/VTN/TPST1/KITLG/PDGFRB/EPHA3/GAS6/CD36/FGFR1/ANGPT1/PRLR/PEAK1/IL6ST/IGF2/CD81/AXL/PRNP/SOCS3/TNFRSF1A/ABI2/RAP2B/ABL1/HIPK3/DSTYK/FER/HIPK1/JAK1 32 GO:0048678 response to axon injury 12/803 83/18722 0.000210153586892191 0.00314662397671011 APOD/FLRT3/MAP1B/DPYSL3/FLNA/LGALS1/PTEN/LAMB2/LRP1/TSPO/KLF4/CERS2 12 GO:0006979 response to oxidative stress 36/803 446/18722 0.000218608562072863 0.00326342003142304 HGF/COL1A1/APOD/PDGFRA/MMP2/FBLN5/PDGFRB/GATA4/CD36/CRYAB/APOE/SOD3/AXL/EPAS1/GPX7/PKD2/PTPRK/SESN3/PRNP/STX2/TXNIP/KLF4/SDC1/ABL1/GPX8/CAPN2/TPM1/PLA2R1/DAPK1/SETX/FOXO3/PRKAA1/FER/SLC8A1/GCLM/HSPB1 36 GO:0030204 chondroitin sulfate metabolic process 7/803 30/18722 0.000222881261411472 0.0033172715504406 DCN/CSGALNACT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2 7 GO:0006936 muscle contraction 30/803 347/18722 0.000225530253529102 0.00334670786933365 STC1/MYL9/SPX/DES/FXYD1/TBX2/PRKG1/GATA4/LMOD1/CRYAB/EDNRB/ACTA2/TPM2/MYLK/KCNMA1/GJA1/BIN1/CALD1/FLNA/ATP1B1/CAMK2D/SMAD5/ROCK2/APBB2/SULF2/TPM4/TPM1/SLC8A1/ZDHHC21/GSN 30 GO:1904035 regulation of epithelial cell apoptotic process 13/803 96/18722 0.000226899248652594 0.00335703161359595 CD248/GAS6/THBS1/ANGPT1/MDK/YAP1/NUPR1/ZFP36L1/ABL1/PLA2R1/FOXO3/SORT1/GSN 13 GO:0050680 negative regulation of epithelial cell proliferation 18/803 164/18722 0.00024430244968285 0.00360382252697837 WFDC1/MCC/SNAI2/BMP4/SPARC/GPC3/THBS1/APOE/GJA1/CASK/TGFBR3/SERPINF1/NFIB/PTEN/ROBO1/B2M/PTPRK/NUPR1 18 GO:0052548 regulation of endopeptidase activity 35/803 432/18722 0.000248037610557891 0.00364812839599304 HGF/F3/COL6A3/WFDC1/PROS1/VTN/GAS6/SERPINE2/THBS1/CRYAB/TIMP1/BIN1/UACA/SERPING1/SERPINF1/TIMP3/ROBO1/TFPI/A2M/SERPINH1/ROCK2/EGLN3/PRNP/BST2/DLC1/KLF4/PLAUR/TIMP2/DAPK1/STAT3/IFI16/GSN/SERPINB9/CRIM1/USP47 35 GO:0050920 regulation of chemotaxis 22/803 223/18722 0.000249858620733743 0.00366410318523071 RARRES2/PDGFRA/F3/SLIT2/ADGRA2/CSF1/PDGFRB/SMOC2/GAS6/THBS1/FGFR1/CMKLR1/EFNB2/SEMA3B/ROBO1/MDK/DPP4/BMPR2/SEMA6D/WNK1/MTUS1/HSPB1 22 GO:0010543 regulation of platelet activation 8/803 40/18722 0.000250836363492358 0.00366765427675336 PDGFRA/PDPN/PRKG1/SERPINE2/APOE/PRKCA/IL6ST/CD9 8 GO:0030168 platelet activation 15/803 123/18722 0.000251965075264174 0.00367338557095664 COL3A1/PDGFRA/PDPN/MYL9/PRKG1/SERPINE2/APOE/PRKCA/IL6ST/FLNA/CD9/AXL/RAP2B/VCL/HSPB1 15 GO:0042063 gliogenesis 27/803 301/18722 0.000254334211063585 0.00369711479989223 NDN/LAMA2/LAMC3/CSF1/MXRA8/SERPINE2/TMEM98/BIN1/IL6ST/VIM/CD9/NFIB/PTEN/LAMB2/MDK/LRP1/CLU/TSPO/NDRG1/LAMB1/ABL1/PLEC/RTN4/SKI/STAT3/ZMIZ1/CERS2 27 GO:0055123 digestive system development 16/803 137/18722 0.000262590706657734 0.00380603855638215 TCF21/RARRES2/PDGFRA/CLMP/TBX2/GATA6/GATA4/BMP4/EDNRB/IL6ST/IGF2/EXT1/PKD1/TGFBR2/YAP1/EPB41L5 16 GO:0048660 regulation of smooth muscle cell proliferation 19/803 180/18722 0.000275570131697931 0.00398258746853879 IGFBP3/APOD/MMP2/IGFBP5/ELN/PDGFRB/EFEMP2/PRKG1/VIPR2/BMP4/THBS1/APOE/GJA1/ADAMTS1/PTEN/TGFBR2/KLF4/BMPR2/TPM1 19 GO:0002063 chondrocyte development 7/803 31/18722 0.000277325706979772 0.00399637565029232 ECM1/COL11A1/EXT1/SERPINH1/TGFBR2/SULF2/BMPR2 7 GO:0014031 mesenchymal cell development 12/803 86/18722 0.000295062318317168 0.00421541753332206 PITX2/HAND2/KITLG/SNAI2/BMP4/EDNRB/RDH10/SEMA3B/NRP2/TWIST1/SEMA6D/JAG1 12 GO:0035023 regulation of Rho protein signal transduction 12/803 86/18722 0.000295062318317168 0.00421541753332206 COL3A1/PDGFRB/LPAR1/KANK2/APOE/HEG1/ROBO1/ITGB1/EPS8/DLC1/ABL1/AKAP13 12 GO:0048864 stem cell development 12/803 86/18722 0.000295062318317168 0.00421541753332206 PITX2/HAND2/KITLG/SNAI2/BMP4/EDNRB/RDH10/SEMA3B/NRP2/TWIST1/SEMA6D/JAG1 12 GO:0010763 positive regulation of fibroblast migration 5/803 15/18722 0.000300480619087519 0.00426269363451253 DDR2/AKAP12/THBS1/ITGB1/SLC8A1 5 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 5/803 15/18722 0.000300480619087519 0.00426269363451253 RSPO3/GPC3/MLLT3/ABL1/DAB2 5 GO:0055007 cardiac muscle cell differentiation 15/803 125/18722 0.000300936253379144 0.00426269363451253 PDGFRA/SORBS2/PDGFRB/GATA6/GATA4/BMP4/EFNB2/NEBL/SGCB/PDLIM5/ITGB1/PLEC/FRS2/SLC8A1/AKAP13 15 GO:0062197 cellular response to chemical stress 29/803 337/18722 0.000308042352379061 0.00435098914720113 HGF/PDGFRA/MMP2/FBLN5/GATA4/CD36/MYLK/SOD3/AXL/EPAS1/GPX7/PKD2/PTPRK/TSPO/STX2/ZFP36L1/KLF4/ABL1/GPX8/PLEC/TPM1/PLA2R1/DAPK1/SETX/FOXO3/PRKAA1/FER/ATM/HSPB1 29 GO:0030239 myofibril assembly 10/803 63/18722 0.000323715241980675 0.00455944688281255 PDGFRA/PDGFRB/LMOD1/NEBL/CFL2/ITGB1/PRKAR1A/PLEC/TPM1/AKAP13 10 GO:0031103 axon regeneration 9/803 52/18722 0.000329037069966174 0.00458734874351781 APOD/MAP1B/FLNA/PTEN/LAMB2/LRP1/TSPO/KLF4/CERS2 9 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 9/803 52/18722 0.000329037069966174 0.00458734874351781 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/DAAM1 9 GO:2000737 negative regulation of stem cell differentiation 6/803 23/18722 0.00032937642402314 0.00458734874351781 PRICKLE1/YAP1/ZFP36L2/N4BP2L2/JAG1/STAT3 6 GO:2000810 regulation of bicellular tight junction assembly 6/803 23/18722 0.00032937642402314 0.00458734874351781 SNAI2/GJA1/CLDN1/ROCK2/MYO1C/TJP1 6 GO:0071375 cellular response to peptide hormone stimulus 26/803 290/18722 0.000331053691999055 0.00459786548275011 ENPP1/RARRES2/MAP1B/IGF2/IRS1/PTEN/PDK4/PDE3B/ZNF106/PIK3R1/SOCS2/SESN3/ROCK2/SOCS3/ZFP36L1/RHOQ/FBN1/PTPRA/LPIN1/PID1/STAT3/PRKAA1/FER/MYO1C/EIF4EBP2/NUCKS1 26 GO:0048662 negative regulation of smooth muscle cell proliferation 11/803 75/18722 0.000336501003039911 0.00466053889210277 IGFBP3/APOD/IGFBP5/EFEMP2/PRKG1/VIPR2/APOE/PTEN/KLF4/BMPR2/TPM1 11 GO:0060323 head morphogenesis 7/803 32/18722 0.000341961700681097 0.00472304997117991 COL1A1/PDGFRA/MMP2/CRISPLD2/RRAS/ARID5B/SKI 7 GO:0030048 actin filament-based movement 15/803 127/18722 0.000357886427920972 0.00491576234053434 PDPN/STC1/GATA4/MYO1B/GJA1/BIN1/FLNA/MYO1E/CAMK2D/TPM1/EPB41L5/WASL/MYO1C/GSN/ACTN4 15 GO:0048565 digestive tract development 15/803 127/18722 0.000357886427920972 0.00491576234053434 TCF21/RARRES2/PDGFRA/CLMP/TBX2/GATA6/GATA4/BMP4/EDNRB/IL6ST/EXT1/PKD1/TGFBR2/YAP1/EPB41L5 15 GO:0048659 smooth muscle cell proliferation 19/803 184/18722 0.000364546186897718 0.00498229210116203 IGFBP3/APOD/MMP2/IGFBP5/ELN/PDGFRB/EFEMP2/PRKG1/VIPR2/BMP4/THBS1/APOE/GJA1/ADAMTS1/PTEN/TGFBR2/KLF4/BMPR2/TPM1 19 GO:0032355 response to estradiol 16/803 141/18722 0.000364728563362243 0.00498229210116203 COL1A1/IGFBP2/WFDC1/PTGFR/PDGFRB/MAP1B/CRYAB/GJA1/PTEN/NCOR2/TFPI/SOCS2/TXNIP/STAT3/STRN3/NCOA1 16 GO:0007548 sex differentiation 25/803 276/18722 0.000366688577329506 0.0049953804550954 TCF21/PDGFRA/SLIT2/FST/SLIT3/KITLG/PDGFRB/GATA6/HOXA13/GATA4/ADAMTS1/FLNA/ACVR2A/RDH10/BASP1/SMAD5/PKD1/AXL/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/FOXO3/NCOA1 25 GO:0014855 striated muscle cell proliferation 11/803 76/18722 0.000378463892514752 0.00514174650702604 WNT2/TBX2/GATA6/ANGPT1/GJA1/TGFBR3/PTEN/TGFBR2/YAP1/PRKAR1A/STAT3 11 GO:0008347 glial cell migration 9/803 53/18722 0.000381471346714844 0.00516852210521796 NDN/CSF1/CD9/LRP1/TSPO/LAMB1/RTN4/ZMIZ1/CERS2 9 GO:0018108 peptidyl-tyrosine phosphorylation 31/803 375/18722 0.000390182647108663 0.00527222406093169 HGF/PDGFRA/FGF7/ENPP2/THY1/DDR2/VTN/KITLG/PDGFRB/EPHA3/GAS6/CD36/FGFR1/ANGPT1/PRLR/PEAK1/IL6ST/IGF2/CD81/AXL/PRNP/SOCS3/TNFRSF1A/ABI2/RAP2B/ABL1/HIPK3/DSTYK/FER/HIPK1/JAK1 31 GO:0014910 regulation of smooth muscle cell migration 12/803 89/18722 0.000407433229430721 0.00546700775957628 IGFBP3/SLIT2/IGFBP5/VTN/PDGFRB/PRKG1/ADAMTS1/PLAU/MDK/LRP1/SEMA6D/TPM1 12 GO:0030278 regulation of ossification 14/803 115/18722 0.000407887462206654 0.00546700775957628 ENPP1/MGP/DDR2/ECM1/CSF1/BMP4/OSR2/ACVR2A/MDK/TWIST1/BMPR2/LTBP3/SLC8A1/NBR1 14 GO:0071675 regulation of mononuclear cell migration 14/803 115/18722 0.000407887462206654 0.00546700775957628 APOD/BMP5/RARRES2/SLIT2/ECM1/CSF1/GAS6/THBS1/CMKLR1/MDK/PLCB1/WNK1/WASL/MSN 14 GO:0014897 striated muscle hypertrophy 13/803 102/18722 0.000415430254344855 0.00553227785593016 SORBS2/IGFBP5/HAND2/GATA6/GATA4/PRKCA/IL6ST/CAMK2D/PDLIM5/LMCD1/ROCK2/TNFRSF1A/AKAP13 13 GO:0048048 embryonic eye morphogenesis 7/803 33/18722 0.000418125603799439 0.00553227785593016 TBX2/MFAP2/TWIST1/FBN1/FRS2/SP3/HIPK1 7 GO:1900181 negative regulation of protein localization to nucleus 7/803 33/18722 0.000418125603799439 0.00553227785593016 APOD/CD36/TMEM98/ANGPT1/MFHAS1/RAB23/PKIG 7 GO:0048645 animal organ formation 10/803 65/18722 0.000419770265826704 0.00553227785593016 WNT2/HAND2/GATA6/BMP4/SPRY1/RDH10/EXT1/ROBO1/TGFBR2/FRS2 10 GO:0033631 cell-cell adhesion mediated by integrin 5/803 16/18722 0.000421696241871376 0.00553227785593016 PLPP3/PIEZO1/DPP4/ITGB1/WNK1 5 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 5/803 16/18722 0.000421696241871376 0.00553227785593016 RSPO3/GPC3/MLLT3/ABL1/DAB2 5 GO:0061383 trabecula morphogenesis 8/803 43/18722 0.000422200157523087 0.00553227785593016 COL1A1/BMP5/MMP2/HEG1/ADAMTS1/TGFBR3/ENG/SOS1 8 GO:0098743 cell aggregation 6/803 24/18722 0.000423353943238872 0.00553227785593016 MGP/COL11A1/SOX5/THRA/PKD1/BMP1 6 GO:1903077 negative regulation of protein localization to plasma membrane 6/803 24/18722 0.000423353943238872 0.00553227785593016 RHOQ/PID1/DAB2/TMEM59/CLTC/HECTD1 6 GO:0034101 erythrocyte homeostasis 15/803 129/18722 0.000423852816078083 0.00553227785593016 BMP4/THRA/ACVR2A/MFHAS1/TGFBR3/SMAD5/AXL/EPAS1/B2M/ZFP36L1/FOXO3/STAT3/SP3/KMT2E/PKNOX1 15 GO:0008154 actin polymerization or depolymerization 21/803 217/18722 0.000443173200769226 0.00576935138129338 SLIT2/ELN/PLEKHH2/LMOD1/BIN1/CDC42EP5/MYADM/GAS7/SPTBN1/CFL2/ENAH/ABI2/EPS8/NCKAP1/ARHGAP28/TTC17/WASL/FER/MYO1C/GSN/CDC42EP3 21 GO:0007249 I-kappaB kinase/NF-kappaB signaling 25/803 281/18722 0.000479234223114976 0.00622255686575851 ECM1/CD36/LPAR1/ANGPT1/GJA1/CXXC5/FLNA/LGALS1/MTDH/S100A4/ROCK2/TIFA/BST2/TNFRSF1A/GOLT1B/ABL1/ASH1L/LITAF/ZMYND11/MIER1/AKAP13/LTBR/NDFIP1/HSPB1/TSPAN6 25 GO:0048638 regulation of developmental growth 28/803 330/18722 0.000486397846401486 0.00629916795365665 WNT2/CSF1/TBX2/GATA6/MAP1B/MAEL/BMP4/APOE/GJA1/IGF2/TGFBR3/SEMA3B/PTEN/NRCAM/BASP1/LRP1/SOCS2/PLCB1/TGFBR2/YAP1/BMPR2/ABL1/SEMA6D/RTN4/STAT3/DPYSL2/MACF1/GOLGA4 28 GO:0060249 anatomical structure homeostasis 27/803 314/18722 0.000495597398523744 0.0064016803861124 LAMA2/CYTL1/CSF1/LDB2/HOXA13/PROM1/ANGPT1/CTSK/GJA1/PRKCA/LAMC1/CLDN1/CFL2/PDK4/EXT1/EPAS1/B2M/APBB2/YAP1/ITGB1/LTBP3/GPR137B/TAOK1/VCL/PRKAA1/TJP1/HSPB1 27 GO:0097191 extrinsic apoptotic signaling pathway 21/803 219/18722 0.000500619764627182 0.00644984533961532 HGF/BMP5/SRPX/KITLG/SNAI2/BMP4/THBS1/FGFR1/PTEN/TIMP3/PIK3R1/YAP1/TNFRSF1A/SKIL/ZMYND11/FOXO3/HIPK1/SORT1/GCLM/RB1CC1/LTBR 21 GO:0014896 muscle hypertrophy 13/803 104/18722 0.000502370216549299 0.00645571623637837 SORBS2/IGFBP5/HAND2/GATA6/GATA4/PRKCA/IL6ST/CAMK2D/PDLIM5/LMCD1/ROCK2/TNFRSF1A/AKAP13 13 GO:0001755 neural crest cell migration 9/803 55/18722 0.000507061255975788 0.00648029120788154 PITX2/HAND2/KITLG/BMP4/EDNRB/SEMA3B/NRP2/TWIST1/SEMA6D 9 GO:1990000 amyloid fibril formation 7/803 34/18722 0.000507249972283941 0.00648029120788154 CD36/CRYAB/APOE/B2M/CLU/GSN/USP9X 7 GO:0071214 cellular response to abiotic stimulus 28/803 331/18722 0.000510276968200851 0.00648029120788154 COL1A1/CCND2/MMP2/MFAP4/PALM/CRYAB/MYLK/TIMP1/GJA1/PIEZO1/PTEN/PKD2/PTPRK/PIK3R1/TSPO/YAP1/ENG/ZFP36L1/TNFRSF1A/CNN2/PLEC/SLC38A2/IFI16/ATM/NUCKS1/LTBR/CLOCK/USP47 28 GO:0104004 cellular response to environmental stimulus 28/803 331/18722 0.000510276968200851 0.00648029120788154 COL1A1/CCND2/MMP2/MFAP4/PALM/CRYAB/MYLK/TIMP1/GJA1/PIEZO1/PTEN/PKD2/PTPRK/PIK3R1/TSPO/YAP1/ENG/ZFP36L1/TNFRSF1A/CNN2/PLEC/SLC38A2/IFI16/ATM/NUCKS1/LTBR/CLOCK/USP47 28 GO:0030099 myeloid cell differentiation 31/803 381/18722 0.000510781075952155 0.00648029120788154 CSF1/KITLG/BMP4/GPC3/PRKCA/THRA/ACVR2A/MEIS2/MFHAS1/CD81/TGFBR3/SMAD5/EPAS1/B2M/SH3PXD2A/PIK3R1/TGFBR2/ZFP36L1/NOTCH2/FBN1/GPR137B/JAG1/FOXO3/GLO1/STAT3/SP3/IFI16/KMT2E/PKNOX1/LTBR/NDFIP1 31 GO:0090330 regulation of platelet aggregation 6/803 25/18722 0.000537002455366654 0.00677846643660288 PDPN/PRKG1/SERPINE2/PRKCA/IL6ST/CD9 6 GO:1905048 regulation of metallopeptidase activity 6/803 25/18722 0.000537002455366654 0.00677846643660288 ANTXR1/TIMP1/TIMP3/LRP1/TIMP2/STAT3 6 GO:0001894 tissue homeostasis 24/803 268/18722 0.000561351856842172 0.0070679301975128 LAMA2/CYTL1/CSF1/LDB2/HOXA13/PROM1/ANGPT1/CTSK/GJA1/PRKCA/LAMC1/CLDN1/PDK4/EXT1/EPAS1/B2M/APBB2/YAP1/ITGB1/LTBP3/GPR137B/VCL/TJP1/HSPB1 24 GO:0008406 gonad development 21/803 221/18722 0.000564436410767206 0.00708886635789746 TCF21/PDGFRA/SLIT2/FST/SLIT3/KITLG/PDGFRB/GATA6/GATA4/ADAMTS1/FLNA/ACVR2A/RDH10/BASP1/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/FOXO3/NCOA1 21 GO:0003184 pulmonary valve morphogenesis 5/803 17/18722 0.000576422310000196 0.00716718612883037 SLIT2/BMP4/ROBO1/NOTCH2/JAG1 5 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 5/803 17/18722 0.000576422310000196 0.00716718612883037 HLA-B/HLA-A/HLA-C/B2M/HLA-F 5 GO:1901550 regulation of endothelial cell development 5/803 17/18722 0.000576422310000196 0.00716718612883037 ROCK2/PLCB1/TNFRSF1A/VCL/ZDHHC21 5 GO:1903140 regulation of establishment of endothelial barrier 5/803 17/18722 0.000576422310000196 0.00716718612883037 ROCK2/PLCB1/TNFRSF1A/VCL/ZDHHC21 5 GO:0030166 proteoglycan biosynthetic process 9/803 56/18722 0.000581526099546868 0.00719476211498929 CYTL1/CSGALNACT1/DSEL/CSGALNACT2/SLC2A10/EXT1/UGDH/BMPR2/CHPF2 9 GO:0090175 regulation of establishment of planar polarity 9/803 56/18722 0.000581526099546868 0.00719476211498929 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/DAAM1 9 GO:0048562 embryonic organ morphogenesis 25/803 285/18722 0.000590020680798291 0.00728178988727792 TCF21/CTHRC1/PDGFRA/HAND2/COL11A1/TBX2/GATA4/BMP4/MFAP2/OSR2/TSHZ1/RDH10/PTK7/PKD2/TWIST1/TGFBR2/YAP1/ENG/NOTCH2/FBN1/FRS2/SP3/HIPK1/CEP290/MIB1 25 GO:0120193 tight junction organization 11/803 80/18722 0.000592876532901006 0.00729896887171461 SNAI2/GJA1/CLDN1/EXT1/SVEP1/MTDH/ROCK2/MPDZ/PLEC/MYO1C/TJP1 11 GO:0090263 positive regulation of canonical Wnt signaling pathway 13/803 106/18722 0.000604237243804073 0.00742050960001751 COL1A1/ADGRA2/RSPO3/RSPO2/GPC3/BAMBI/ZEB2/PTK7/YAP1/SULF2/WNK1/TBL1XR1/USP47 13 GO:0042698 ovulation cycle 10/803 68/18722 0.000607392682742979 0.00744093345492996 PDGFRA/SLIT2/SLIT3/ADAMTS1/SERPINF1/MDK/NCOR2/AXL/FOXO3/NCOA1 10 GO:0060349 bone morphogenesis 12/803 93/18722 0.000611712576939824 0.00747548752113226 COL1A1/STC1/BMP4/OSR2/RAB23/EXT1/SERPINH1/TWIST1/TGFBR2/BMPR2/LTBP3/SKI 12 GO:0071453 cellular response to oxygen levels 18/803 177/18722 0.000618120360868742 0.00753532547504046 STC1/GATA6/VASN/PTEN/EPAS1/EIF4EBP1/ROCK2/EGLN3/TWIST1/NDRG1/MALAT1/ZFP36L1/NPEPPS/FOXO3/PRKAA1/BNIP3L/SLC8A1/BACH1 18 GO:0030218 erythrocyte differentiation 14/803 120/18722 0.000630003490969852 0.00766145708774556 BMP4/THRA/ACVR2A/MFHAS1/TGFBR3/SMAD5/EPAS1/B2M/ZFP36L1/FOXO3/STAT3/SP3/KMT2E/PKNOX1 14 GO:0010976 positive regulation of neuron projection development 17/803 163/18722 0.000650278898299862 0.00788878488302461 HGF/BMP5/EPHA3/DPYSL3/APOE/FLNA/SERPINF1/PTK7/TMEM106B/MDK/LRP1/SCARB2/SETX/PLXNB2/NPTN/VLDLR/KIDINS220 17 GO:0010927 cellular component assembly involved in morphogenesis 13/803 107/18722 0.000661379376097534 0.00800397468257841 PDGFRA/PMP22/PDGFRB/PHLDB1/LMOD1/CD9/NEBL/CFL2/ITGB1/PRKAR1A/PLEC/TPM1/AKAP13 13 GO:0003416 endochondral bone growth 6/803 26/18722 0.000673007453968522 0.00808581967587241 STC1/DDR2/ECM1/BNC2/EXT1/TGFBR2 6 GO:0060669 embryonic placenta morphogenesis 6/803 26/18722 0.000673007453968522 0.00808581967587241 BMP5/RSPO3/IGF2/SOCS3/ZFP36L1/NCOA1 6 GO:1904376 negative regulation of protein localization to cell periphery 6/803 26/18722 0.000673007453968522 0.00808581967587241 RHOQ/PID1/DAB2/TMEM59/CLTC/HECTD1 6 GO:0050919 negative chemotaxis 8/803 46/18722 0.000678308429920477 0.00812991786438341 SLIT2/SLIT3/FLRT3/SEMA3B/ROBO1/NRP2/DPP4/SEMA6D 8 GO:0048872 homeostasis of number of cells 24/803 272/18722 0.000692943580532076 0.00828541173269289 PLA2G2A/CSF1/KITLG/BMP4/THRA/ACVR2A/MFHAS1/GLIS2/TGFBR3/EXT1/SMAD5/FSTL1/AXL/EPAS1/B2M/ZFP36L1/ABL1/SKIL/FOXO3/STAT3/SP3/KMT2E/PKNOX1/SOS1 24 GO:0003203 endocardial cushion morphogenesis 7/803 36/18722 0.00073058602194123 0.00867309977475946 BMP5/TBX2/SNAI2/ROBO1/TWIST1/TGFBR2/ENG 7 GO:0003230 cardiac atrium development 7/803 36/18722 0.00073058602194123 0.00867309977475946 WNT2/GATA4/HEG1/ENG/NOTCH2/BMPR2/SOS1 7 GO:0070306 lens fiber cell differentiation 7/803 36/18722 0.00073058602194123 0.00867309977475946 MAF/SPRY1/VIM/ABI2/SPRED1/SKIL/FRS2 7 GO:0030516 regulation of axon extension 12/803 95/18722 0.000742433285799218 0.00879280846317079 MAP1B/APOE/SEMA3B/NRCAM/LRP1/BMPR2/ABL1/SEMA6D/RTN4/DPYSL2/MACF1/GOLGA4 12 GO:0051495 positive regulation of cytoskeleton organization 21/803 226/18722 0.000755728900418839 0.00892906231632306 SYNPO2/MAP1B/LMOD1/LPAR1/BIN1/CDC42EP5/FLNA/CFL2/ROCK2/NIN/ABI2/SORBS3/NCKAP1/ABL1/TPM1/WASL/FER/MYO1C/CCDC88A/GSN/CDC42EP3 21 GO:0051895 negative regulation of focal adhesion assembly 5/803 18/18722 0.000770124343326158 0.00903491759017465 APOD/THBS1/PTEN/LRP1/DLC1 5 GO:0060008 Sertoli cell differentiation 5/803 18/18722 0.000770124343326158 0.00903491759017465 TCF21/FLNA/SDC1/ATRX/FNDC3A 5 GO:0150118 negative regulation of cell-substrate junction organization 5/803 18/18722 0.000770124343326158 0.00903491759017465 APOD/THBS1/PTEN/LRP1/DLC1 5 GO:0030100 regulation of endocytosis 20/803 211/18722 0.000779895646278143 0.00909159332299316 VTN/EPHA3/CD36/GPC3/APOE/ANGPT1/BIN1/CD63/LRP1/AXL/B2M/CLU/STON1/CD151/ABL1/AP2B1/DAB2/WASL/MIB1/ITSN1 20 GO:0043491 protein kinase B signaling 20/803 211/18722 0.000779895646278143 0.00909159332299316 F3/IGFBP5/GATA4/GAS6/THBS1/FGFR1/ANGPT1/IGF2/MFHAS1/PTEN/RRAS/AXL/MTDH/SESN3/ENG/ZFP36L1/ITGB1/KLF4/RTN4/SETX 20 GO:0044409 entry into host 16/803 151/18722 0.000780425580072417 0.00909159332299316 GAS6/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ITGB1/SCARB2/TPCN1/FUCA2/GSN 16 GO:0010761 fibroblast migration 8/803 47/18722 0.000787174827251568 0.0091275667178519 DDR2/AKAP12/THBS1/ITGB1/PLEC/ARID5B/FER/SLC8A1 8 GO:0097028 dendritic cell differentiation 8/803 47/18722 0.000787174827251568 0.0091275667178519 GAS6/TMEM176A/TMEM176B/HLA-B/AXL/TGFBR2/NOTCH2/LTBR 8 GO:0072009 nephron epithelium development 13/803 109/18722 0.000789397851180735 0.00913210599997017 TCF21/BMP4/PROM1/GPC3/MYO1E/LAMB2/EXT1/BASP1/PKD1/PKD2/YAP1/NOTCH2/JAG1 13 GO:0051960 regulation of nervous system development 34/803 443/18722 0.000794874155836361 0.0091704712821429 HGF/WNT2/SLIT2/THY1/FLRT3/PTPRD/MAP1B/SERPINE2/AMIGO2/TMEM98/BIN1/IL6ST/SERPINF1/SEMA3B/PTEN/ROBO1/MDK/LRP1/B2M/TSPO/YAP1/NIN/BMPR2/LPIN1/SEMA6D/SKIL/RTN4/PLXNB2/NPTN/SKI/CLSTN1/CERS2/MACF1/GOLGA4 34 GO:0045664 regulation of neuron differentiation 19/803 196/18722 0.000796878520730536 0.0091704712821429 MAP1B/TCF4/BMP4/EDNRB/FGFR1/BIN1/PTEN/NRCAM/B2M/SOCS2/TUG1/TIMP2/JAG1/FOXO3/DPYSL2/TCF12/MIB1/ZFHX3/NCOA1 19 GO:1902904 negative regulation of supramolecular fiber organization 17/803 166/18722 0.000799885358109902 0.0091704712821429 SLIT2/EMILIN1/MAP1B/PLEKHH2/LMOD1/CRYAB/APOE/MYADM/SPTBN1/CLU/PIK3R1/EPS8/DLC1/ARHGAP28/TAOK1/GSN/TJP1 17 GO:0045137 development of primary sexual characteristics 21/803 227/18722 0.000800071200908977 0.0091704712821429 TCF21/PDGFRA/SLIT2/FST/SLIT3/KITLG/PDGFRB/GATA6/GATA4/ADAMTS1/FLNA/ACVR2A/RDH10/BASP1/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/FOXO3/NCOA1 21 GO:0090090 negative regulation of canonical Wnt signaling pathway 15/803 137/18722 0.000802110345860462 0.00917275730380795 CTHRC1/IGFBP2/DKK3/MCC/BICC1/SNAI2/GPC3/APOE/PRICKLE1/MLLT3/RBMS3/MDK/DAB2/AMFR/FOXO3 15 GO:1901655 cellular response to ketone 12/803 96/18722 0.000816081005391593 0.00931116680293475 PTGFR/GAS6/ADCY3/PTGER2/SERPINF1/GNAI1/NR3C1/ROCK2/KLF4/FOXO3/PRKAA1/MSN 12 GO:0003272 endocardial cushion formation 6/803 27/18722 0.000834216345657461 0.00941041334716764 BMP5/TBX2/SNAI2/ROBO1/TGFBR2/ENG 6 GO:0010758 regulation of macrophage chemotaxis 6/803 27/18722 0.000834216345657461 0.00941041334716764 RARRES2/CSF1/THBS1/CMKLR1/MDK/MTUS1 6 GO:0018126 protein hydroxylation 6/803 27/18722 0.000834216345657461 0.00941041334716764 P4HA2/PLOD2/FKBP10/EGLN3/CRTAP/P3H4 6 GO:0035116 embryonic hindlimb morphogenesis 6/803 27/18722 0.000834216345657461 0.00941041334716764 RSPO2/PITX1/BMP4/GPC3/OSR2/TWIST1 6 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 6/803 27/18722 0.000834216345657461 0.00941041334716764 DCN/ADGRA2/SMOC2/ROBO1/CD63/MYO1C 6 GO:1903829 positive regulation of cellular protein localization 24/803 276/18722 0.000850609543305667 0.00957367761381953 EPHA3/EPB41L2/FLNA/SPTBN1/CD81/GLIS2/LRP1/GNAI1/PIK3R1/ROCK2/PRNP/YAP1/ITGB1/SLC5A3/AP2B1/GPR137B/NPEPPS/RTN4/NPTN/STOM/PRKAA1/MYO1C/MSN/CCDC88A 24 GO:0033555 multicellular organismal response to stress 10/803 71/18722 0.000859465762282446 0.00957636144079103 THBS1/EDNRB/APOE/GJA1/PTEN/EXT1/MDK/DPP4/TSPO/CAPN2 10 GO:0090303 positive regulation of wound healing 9/803 59/18722 0.000860246537354661 0.00957636144079103 F3/VTN/SMOC2/CD36/THBS1/MYLK/PLPP3/CLDN1/ITGB1 9 GO:0035107 appendage morphogenesis 15/803 138/18722 0.000865115726667766 0.00957636144079103 HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/EXT1/TWIST1/NOTCH2/ATRX/SKI 15 GO:0035108 limb morphogenesis 15/803 138/18722 0.000865115726667766 0.00957636144079103 HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/EXT1/TWIST1/NOTCH2/ATRX/SKI 15 GO:0003161 cardiac conduction system development 7/803 37/18722 0.000868133849024778 0.00957636144079103 MSC/GATA6/GATA4/BMP4/GJA1/SMAD5/NOTCH2 7 GO:0030513 positive regulation of BMP signaling pathway 7/803 37/18722 0.000868133849024778 0.00957636144079103 GATA4/BMP4/GPC3/TWSG1/ENG/NOTCH2/BMPR2 7 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 7/803 37/18722 0.000868133849024778 0.00957636144079103 CREB3L1/SMOC2/THBS1/SPRY1/SULF2/DSTYK/NPTN 7 GO:0048846 axon extension involved in axon guidance 7/803 37/18722 0.000868133849024778 0.00957636144079103 SLIT2/SLIT3/SEMA3B/ALCAM/NRP2/BMPR2/SEMA6D 7 GO:1902284 neuron projection extension involved in neuron projection guidance 7/803 37/18722 0.000868133849024778 0.00957636144079103 SLIT2/SLIT3/SEMA3B/ALCAM/NRP2/BMPR2/SEMA6D 7 GO:0014909 smooth muscle cell migration 12/803 97/18722 0.000895727217566399 0.00985893136155864 IGFBP3/SLIT2/IGFBP5/VTN/PDGFRB/PRKG1/ADAMTS1/PLAU/MDK/LRP1/SEMA6D/TPM1 12 GO:0048146 positive regulation of fibroblast proliferation 8/803 48/18722 0.000909647338176808 0.00999009169195939 PDGFRA/WNT2/DDR2/PDGFRB/GAS6/S100A6/FOSL2/ZMIZ1 8 GO:1904375 regulation of protein localization to cell periphery 14/803 125/18722 0.000947119622988765 0.0103787658026857 EPHA3/EPB41L2/SPTBN1/LRP1/GNAI1/PIK3R1/PRNP/ITGB1/RHOQ/PID1/DAB2/TMEM59/CLTC/HECTD1 14 GO:0051057 positive regulation of small GTPase mediated signal transduction 10/803 72/18722 0.000960460983374152 0.0105018825945253 COL3A1/CSF1/KITLG/PDGFRB/LPAR1/ROBO1/NOTCH2/MAP4K4/SOS1/AKAP13 10 GO:0008360 regulation of cell shape 16/803 154/18722 0.000965350595090705 0.0105092534216643 PDPN/PALM/LPAR1/FBLIM1/BAMBI/CDC42EP5/MYO10/RND3/FMNL2/EPS8/RHOQ/DLC1/TPM1/PLXNB2/MSN/CDC42EP3 16 GO:0050770 regulation of axonogenesis 16/803 154/18722 0.000965350595090705 0.0105092534216643 SLIT2/THY1/MAP1B/CHN1/SEMA3B/PTEN/ROBO1/LRP1/NIN/BMPR2/SEMA6D/SKIL/RTN4/PLXNB2/MACF1/GOLGA4 16 GO:0030900 forebrain development 30/803 379/18722 0.000972457765405187 0.010559681446998 COL3A1/PITX2/SLIT2/PRKG1/PITX1/BMP4/FLNA/TWSG1/NFIB/PTEN/EXT1/ROBO1/MDK/LRP1/NRP2/AXL/B2M/PLCB1/NIN/LAMB1/DLC1/BTBD3/SLC38A2/RTN4/ATRX/FRS2/SKI/ZMIZ1/SLC8A1/NCOA1 30 GO:0060038 cardiac muscle cell proliferation 9/803 60/18722 0.000974218504937645 0.010559681446998 WNT2/TBX2/GATA6/GJA1/TGFBR3/PTEN/TGFBR2/YAP1/PRKAR1A 9 GO:0055013 cardiac muscle cell development 11/803 85/18722 0.000994736199627194 0.0107586869660329 PDGFRA/SORBS2/PDGFRB/GATA4/BMP4/NEBL/SGCB/PDLIM5/PLEC/SLC8A1/AKAP13 11 GO:0002483 antigen processing and presentation of endogenous peptide antigen 5/803 19/18722 0.00100854437172812 0.0107678848767375 HLA-B/HLA-A/HLA-C/B2M/HLA-F 5 GO:0010544 negative regulation of platelet activation 5/803 19/18722 0.00100854437172812 0.0107678848767375 PDGFRA/PRKG1/SERPINE2/APOE/CD9 5 GO:0010759 positive regulation of macrophage chemotaxis 5/803 19/18722 0.00100854437172812 0.0107678848767375 RARRES2/CSF1/THBS1/CMKLR1/MDK 5 GO:0030050 vesicle transport along actin filament 5/803 19/18722 0.00100854437172812 0.0107678848767375 MYO1B/MYO1E/WASL/MYO1C/ACTN4 5 GO:0060039 pericardium development 5/803 19/18722 0.00100854437172812 0.0107678848767375 BMP5/HAND2/FLRT3/HEG1/SOS1 5 GO:0072074 kidney mesenchyme development 5/803 19/18722 0.00100854437172812 0.0107678848767375 TCF21/PDGFRB/BMP4/BASP1/PKD2 5 GO:0045216 cell-cell junction organization 19/803 200/18722 0.00101601543514145 0.0108244721359301 CDH11/SNAI2/HEG1/FSCN1/GJA1/PRKCA/FLNA/CLDN1/CD9/EXT1/SVEP1/MTDH/ROCK2/MPDZ/PLEC/VCL/MYO1C/HIPK1/TJP1 19 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 6/803 28/18722 0.00102362905219814 0.0108539188929973 HLA-B/HLA-A/HLA-C/B2M/HLA-F/LNPEP 6 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 7/803 38/18722 0.00102531002779818 0.0108539188929973 TCF21/KANK2/PIAS2/NCOR2/DAB2/STRN3/CLOCK 7 GO:0048246 macrophage chemotaxis 7/803 38/18722 0.00102531002779818 0.0108539188929973 RARRES2/CSF1/THBS1/EDNRB/CMKLR1/MDK/MTUS1 7 GO:0034614 cellular response to reactive oxygen species 16/803 155/18722 0.00103471787580557 0.0109297267637037 HGF/PDGFRA/MMP2/FBLN5/CD36/SOD3/AXL/PKD2/PTPRK/KLF4/ABL1/TPM1/SETX/FOXO3/PRKAA1/FER 16 GO:0051896 regulation of protein kinase B signaling 18/803 185/18722 0.00103685534681746 0.0109297267637037 F3/IGFBP5/GATA4/GAS6/THBS1/FGFR1/ANGPT1/IGF2/MFHAS1/PTEN/RRAS/AXL/MTDH/SESN3/ENG/ITGB1/KLF4/RTN4 18 GO:0030178 negative regulation of Wnt signaling pathway 17/803 170/18722 0.00104434927517087 0.0109663260512387 CTHRC1/IGFBP2/DKK3/MCC/BICC1/SNAI2/GPC3/APOE/PRICKLE1/MLLT3/RBMS3/MDK/LRP1/APCDD1/DAB2/AMFR/FOXO3 17 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 8/803 49/18722 0.00104692563184709 0.0109663260512387 BMP5/GDF6/BMP4/TWSG1/ACVR2A/ENG/BMPR2/DAB2 8 GO:0072091 regulation of stem cell proliferation 8/803 49/18722 0.00104692563184709 0.0109663260512387 KITLG/GJA1/YAP1/ZFP36L1/AGO3/LTBP3/N4BP2L2/FBLN1 8 GO:0050767 regulation of neurogenesis 29/803 364/18722 0.00106080991854537 0.0110884659410214 WNT2/SLIT2/THY1/PTPRD/MAP1B/SERPINE2/TMEM98/BIN1/IL6ST/SERPINF1/SEMA3B/PTEN/ROBO1/MDK/LRP1/B2M/TSPO/YAP1/NIN/BMPR2/SEMA6D/SKIL/RTN4/PLXNB2/NPTN/SKI/CERS2/MACF1/GOLGA4 29 GO:0061035 regulation of cartilage development 10/803 73/18722 0.00107097629018592 0.0111616223282883 SOX5/GDF6/SNAI2/BMP4/MAF/CTSK/MDK/BMPR2/BMP1/LTBP3 10 GO:0003300 cardiac muscle hypertrophy 12/803 99/18722 0.00107452441186891 0.0111616223282883 SORBS2/HAND2/GATA6/GATA4/PRKCA/IL6ST/CAMK2D/PDLIM5/LMCD1/ROCK2/TNFRSF1A/AKAP13 12 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 12/803 99/18722 0.00107452441186891 0.0111616223282883 MAEL/SNAI2/CLU/PIK3R1/NUPR1/TNFRSF1A/ABL1/SKIL/HIPK1/IFI16/ATM/USP47 12 GO:0035296 regulation of tube diameter 15/803 141/18722 0.00107983661786057 0.011170260117537 PRKG1/ITGA1/EDNRB/ACTA2/APOE/KCNMA1/GJA1/SOD3/ECE1/EXT1/ROCK2/BMPR2/SLC8A1/ZDHHC21/GCLM 15 GO:0097746 blood vessel diameter maintenance 15/803 141/18722 0.00107983661786057 0.011170260117537 PRKG1/ITGA1/EDNRB/ACTA2/APOE/KCNMA1/GJA1/SOD3/ECE1/EXT1/ROCK2/BMPR2/SLC8A1/ZDHHC21/GCLM 15 GO:0070374 positive regulation of ERK1 and ERK2 cascade 20/803 217/18722 0.00110400271426143 0.0113965994478416 PDGFRA/PLA2G2A/HAND2/PDGFRB/GATA4/GAS6/CD36/AKAP12/BMP4/APOE/ANGPT1/PRKCA/MFHAS1/PTEN/GPNMB/LRP1/NOTCH2/ABL1/DSTYK/NPTN 20 GO:0001764 neuron migration 16/803 156/18722 0.00110826206285098 0.0114169310854855 COL3A1/NDN/PRKG1/MAP1B/GAS6/FGFR1/FLNA/NRCAM/MDK/NRP2/AXL/TWIST1/PLXNB2/STAT3/ZMIZ1/USP9X 16 GO:0035150 regulation of tube size 15/803 142/18722 0.00116071627530649 0.0119326419560375 PRKG1/ITGA1/EDNRB/ACTA2/APOE/KCNMA1/GJA1/SOD3/ECE1/EXT1/ROCK2/BMPR2/SLC8A1/ZDHHC21/GCLM 15 GO:0008064 regulation of actin polymerization or depolymerization 18/803 187/18722 0.00117310598784033 0.0120351984678434 SLIT2/ELN/PLEKHH2/LMOD1/BIN1/CDC42EP5/MYADM/SPTBN1/CFL2/ABI2/EPS8/NCKAP1/ARHGAP28/WASL/FER/MYO1C/GSN/CDC42EP3 18 GO:0002262 myeloid cell homeostasis 16/803 157/18722 0.00118618096433983 0.0120853879154902 KITLG/BMP4/THRA/ACVR2A/MFHAS1/TGFBR3/SMAD5/AXL/EPAS1/B2M/ZFP36L1/FOXO3/STAT3/SP3/KMT2E/PKNOX1 16 GO:0007219 Notch signaling pathway 17/803 172/18722 0.00118869268779945 0.0120853879154902 DLK1/SORBS2/TBX2/SNAI2/CFD/IL6ST/TSPAN5/ROBO1/NOTCH3/TGFBR2/YAP1/NOTCH2/MAML2/JAG1/STAT3/ZMIZ1/MIB1 17 GO:0048736 appendage development 17/803 172/18722 0.00118869268779945 0.0120853879154902 PITX2/HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/EXT1/TWIST1/NOTCH2/BMPR2/ATRX/SKI 17 GO:0060173 limb development 17/803 172/18722 0.00118869268779945 0.0120853879154902 PITX2/HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/EXT1/TWIST1/NOTCH2/BMPR2/ATRX/SKI 17 GO:0007389 pattern specification process 33/803 436/18722 0.00119011742208297 0.0120853879154902 WNT2/STC1/PITX2/HAND2/FST/TBX2/BICC1/GATA4/BMP4/GPC3/SPRY1/TSHZ1/ACVR2A/MEIS2/MLLT3/EXT1/BASP1/ROBO1/SMAD5/NRP2/PKD2/LRP6/TGFBR2/ENG/NOTCH2/PCSK6/BMPR2/FRS2/EPB41L5/SKI/HIPK1/MIB1/BPTF 33 GO:0021987 cerebral cortex development 13/803 114/18722 0.00120316352333348 0.0121768129904234 COL3A1/SLIT2/FLNA/ROBO1/MDK/LRP1/PLCB1/LAMB1/BTBD3/SLC38A2/RTN4/ZMIZ1/NCOA1 13 GO:0010463 mesenchymal cell proliferation 7/803 39/18722 0.00120400497478515 0.0121768129904234 FGF7/WNT2/HAND2/BMP4/GPC3/NFIB/TGFBR2 7 GO:0019221 cytokine-mediated signaling pathway 35/803 472/18722 0.0012240022485376 0.012353998403256 F3/SLIT2/ECM1/CSF1/SLIT3/ACKR1/GAS6/OSMR/IL1R1/ANGPT1/PRLR/CMKLR1/IL6ST/IFITM2/IFITM3/IFITM1/PLP2/EXT1/ROBO1/AXL/AGPAT2/PLCB1/YAP1/TNFRSF1A/IFNGR2/LIFR/WNK1/FOXO3/STAT3/FER/IFNAR1/HIPK1/SOS1/ACTN4/JAK1 35 GO:0010955 negative regulation of protein processing 6/803 29/18722 0.00124438748631752 0.0124326519659695 SERPINE2/THBS1/TMEM98/GAS1/PRNP/TMEM59 6 GO:0098868 bone growth 6/803 29/18722 0.00124438748631752 0.0124326519659695 STC1/DDR2/ECM1/BNC2/EXT1/TGFBR2 6 GO:1902430 negative regulation of amyloid-beta formation 6/803 29/18722 0.00124438748631752 0.0124326519659695 SPON1/APOE/BIN1/CLU/PRNP/RTN4 6 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 6/803 29/18722 0.00124438748631752 0.0124326519659695 DCN/ADGRA2/SMOC2/ROBO1/CD63/MYO1C 6 GO:1903318 negative regulation of protein maturation 6/803 29/18722 0.00124438748631752 0.0124326519659695 SERPINE2/THBS1/TMEM98/GAS1/PRNP/TMEM59 6 GO:0030832 regulation of actin filament length 18/803 188/18722 0.00124675611371536 0.0124326519659695 SLIT2/ELN/PLEKHH2/LMOD1/BIN1/CDC42EP5/MYADM/SPTBN1/CFL2/ABI2/EPS8/NCKAP1/ARHGAP28/WASL/FER/MYO1C/GSN/CDC42EP3 18 GO:0032908 regulation of transforming growth factor beta1 production 4/803 12/18722 0.00126140120761269 0.0125036708174093 LUM/GATA6/THBS1/LAPTM4B 4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 4/803 12/18722 0.00126140120761269 0.0125036708174093 COL1A1/DDR2/COL4A1/COL4A2 4 GO:0060009 Sertoli cell development 4/803 12/18722 0.00126140120761269 0.0125036708174093 FLNA/SDC1/ATRX/FNDC3A 4 GO:0071383 cellular response to steroid hormone stimulus 19/803 204/18722 0.00128478077859881 0.0127101527025668 TCF21/STC1/BMP4/PLPP1/KANK2/SERPINF1/PIAS2/NCOR2/TFPI/NR3C1/YAP1/ZFP36L2/ZFP36L1/DDX17/DAB2/FOXO3/ZMIZ1/STRN3/CLOCK 19 GO:0006024 glycosaminoglycan biosynthetic process 10/803 75/18722 0.00132323744697099 0.0130646770506878 PDGFRB/HS3ST6/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2/CLTC 10 GO:0046718 viral entry into host cell 15/803 144/18722 0.00133784227689967 0.0131827699458928 GAS6/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ITGB1/SCARB2/TPCN1/GSN 15 GO:0007584 response to nutrient 17/803 174/18722 0.00134960633785828 0.0132724599616595 COL1A1/IGFBP2/STC1/VCAM1/MAP1B/SNAI2/GATA4/GAS6/SPARC/KANK2/C2/PTEN/TSPO/TGFBR2/SLC8A1/GCLM/NCOA1 17 GO:0045668 negative regulation of osteoblast differentiation 8/803 51/18722 0.00137097489443391 0.0134146726497214 IGFBP5/HAND2/BAMBI/TWSG1/TWIST1/SKI/NBR1/CRIM1 8 GO:0060043 regulation of cardiac muscle cell proliferation 8/803 51/18722 0.00137097489443391 0.0134146726497214 WNT2/TBX2/GATA6/GJA1/TGFBR3/PTEN/TGFBR2/YAP1 8 GO:0097305 response to alcohol 22/803 253/18722 0.00137213859834695 0.0134146726497214 VCAM1/SLIT2/PTGFR/SLIT3/ADCY3/SPARC/CES1/PTGER2/CLDN1/TGFBR3/PTEN/GNAI1/TSPO/EIF4EBP1/LRP6/TGFBR2/EPS8/H6PD/KLF4/FOXO3/STAT3/PRKAA1 22 GO:0001841 neural tube formation 12/803 102/18722 0.00139753452328627 0.0136141254140948 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/MIB1/HECTD1 12 GO:0030041 actin filament polymerization 18/803 190/18722 0.00140589617342034 0.0136141254140948 SLIT2/ELN/LMOD1/BIN1/CDC42EP5/MYADM/GAS7/SPTBN1/ABI2/EPS8/NCKAP1/ARHGAP28/TTC17/WASL/FER/MYO1C/GSN/CDC42EP3 18 GO:0030866 cortical actin cytoskeleton organization 7/803 40/18722 0.00140619225596847 0.0136141254140948 EHD2/EPB41L2/ROCK2/FMNL2/RHOQ/NCKAP1/PLEC 7 GO:0060412 ventricular septum morphogenesis 7/803 40/18722 0.00140619225596847 0.0136141254140948 SLIT2/SLIT3/BMP4/TGFBR3/ROBO1/TGFBR2/BMPR2 7 GO:0072210 metanephric nephron development 7/803 40/18722 0.00140619225596847 0.0136141254140948 TCF21/PDGFRA/PDGFRB/BMP4/LAMB2/PKD1/PKD2 7 GO:0030326 embryonic limb morphogenesis 13/803 116/18722 0.00141288496466455 0.0136260047075772 HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/TWIST1/NOTCH2/SKI 13 GO:0035113 embryonic appendage morphogenesis 13/803 116/18722 0.00141288496466455 0.0136260047075772 HAND2/TBX2/RSPO2/HOXA13/PITX1/BMP4/GPC3/OSR2/ECE1/RDH10/TWIST1/NOTCH2/SKI 13 GO:0007159 leukocyte cell-cell adhesion 29/803 371/18722 0.00142000281182946 0.0136682123934009 IGFBP2/VCAM1/THY1/BMP4/IL6ST/TWSG1/IGF2/CERCAM/LGALS1/HLA-A/CD81/GPNMB/EXT1/MDK/DPP4/B2M/NFAT5/PRNP/PAG1/TGFBR2/ITGB1/KLF4/MAP3K8/PRKAR1A/WNK1/ZMIZ1/MSN/ZDHHC21/NDFIP1 29 GO:0031100 animal organ regeneration 10/803 76/18722 0.00146638495522193 0.0140874670264673 HGF/NNMT/GAS6/CLDN1/TGFBR3/AXL/TGFBR2/SULF2/LPIN1/IGF2R 10 GO:0051491 positive regulation of filopodium assembly 6/803 30/18722 0.00149976404254403 0.0143528282459204 DPYSL3/PALM/FSCN1/PIK3R1/RHOQ/WASL 6 GO:0061384 heart trabecula morphogenesis 6/803 30/18722 0.00149976404254403 0.0143528282459204 BMP5/HEG1/ADAMTS1/TGFBR3/ENG/SOS1 6 GO:0034599 cellular response to oxidative stress 24/803 288/18722 0.00152397555220294 0.0145565940675936 HGF/PDGFRA/MMP2/FBLN5/GATA4/CD36/SOD3/AXL/EPAS1/GPX7/PKD2/PTPRK/STX2/KLF4/ABL1/GPX8/TPM1/PLA2R1/DAPK1/SETX/FOXO3/PRKAA1/FER/HSPB1 24 GO:0007043 cell-cell junction assembly 15/803 146/18722 0.00153712394709961 0.0146541108991179 CDH11/SNAI2/HEG1/FSCN1/GJA1/PRKCA/CLDN1/CD9/MTDH/ROCK2/MPDZ/VCL/MYO1C/HIPK1/TJP1 15 GO:0046579 positive regulation of Ras protein signal transduction 9/803 64/18722 0.0015586860788843 0.0147913399664214 COL3A1/CSF1/KITLG/PDGFRB/LPAR1/ROBO1/NOTCH2/MAP4K4/AKAP13 9 GO:0030514 negative regulation of BMP signaling pathway 8/803 52/18722 0.00156041813524622 0.0147913399664214 BAMBI/TWSG1/HTRA1/FBN1/ABL1/SKIL/SKI/CRIM1 8 GO:0072132 mesenchyme morphogenesis 8/803 52/18722 0.00156041813524622 0.0147913399664214 BMP5/TBX2/SNAI2/ACTA2/ROBO1/TWIST1/TGFBR2/ENG 8 GO:0046849 bone remodeling 11/803 90/18722 0.00159893484945939 0.0150990324988722 CTHRC1/CTSK/GJA1/PRKCA/PDK4/EXT1/MDK/NOTCH2/LTBP3/GPR137B/P3H4 11 GO:0097581 lamellipodium organization 11/803 90/18722 0.00159893484945939 0.0150990324988722 PDPN/ENPP2/SLIT2/FSCN1/PIK3R1/ITGB1/ABI2/NCKAP1/VCL/FER/CCDC88A 11 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 23/803 273/18722 0.00164055812873906 0.015395116188537 CDH11/CADM3/VCAM1/PCDH10/FLRT3/SCARF2/PCDH18/PTPRD/AMIGO2/MYADM/NEXN/CLDN1/PALLD/ALCAM/ROBO1/PKD1/TGFBR2/ITGB1/KLF4/WNK1/PLXNB2/NPTN/CLSTN1 23 GO:0046823 negative regulation of nucleocytoplasmic transport 5/803 21/18722 0.00164362907786223 0.015395116188537 APOD/CD36/ANGPT1/RAB23/PKIG 5 GO:0048745 smooth muscle tissue development 5/803 21/18722 0.00164362907786223 0.015395116188537 EFEMP2/BMP4/MYLK/PKD2/ENG 5 GO:0099515 actin filament-based transport 5/803 21/18722 0.00164362907786223 0.015395116188537 MYO1B/MYO1E/WASL/MYO1C/ACTN4 5 GO:0016331 morphogenesis of embryonic epithelium 15/803 147/18722 0.00164572742248099 0.015395116188537 BMP5/CTHRC1/WNT2/BMP4/PRICKLE1/RDH10/PTK7/TWIST1/DLC1/ABL1/PLXNB2/EPB41L5/SKI/MIB1/HECTD1 15 GO:1903076 regulation of protein localization to plasma membrane 12/803 104/18722 0.0016544764462447 0.0154479767059477 EPHA3/SPTBN1/LRP1/PIK3R1/PRNP/ITGB1/RHOQ/PID1/DAB2/TMEM59/CLTC/HECTD1 12 GO:0010001 glial cell differentiation 20/803 225/18722 0.00171048635197413 0.0159410933662486 LAMA2/LAMC3/MXRA8/SERPINE2/TMEM98/BIN1/IL6ST/VIM/CD9/NFIB/PTEN/LAMB2/MDK/LRP1/CLU/NDRG1/ABL1/PLEC/SKI/STAT3 20 GO:0002065 columnar/cuboidal epithelial cell differentiation 11/803 91/18722 0.00174991894313856 0.016195623071156 BMP5/GATA6/GATA4/BMP4/IL6ST/FAM20C/EXT1/YAP1/SIDT2/ABL1/CLOCK 11 GO:0001886 endothelial cell morphogenesis 4/803 13/18722 0.00176053503902257 0.016195623071156 COL15A1/STC1/HOXA13/HEG1 4 GO:0032905 transforming growth factor beta1 production 4/803 13/18722 0.00176053503902257 0.016195623071156 LUM/GATA6/THBS1/LAPTM4B 4 GO:0036302 atrioventricular canal development 4/803 13/18722 0.00176053503902257 0.016195623071156 TBX2/GATA6/GATA4/ENG 4 GO:0044794 positive regulation by host of viral process 4/803 13/18722 0.00176053503902257 0.016195623071156 APOE/IGF2R/STOM/NUCKS1 4 GO:0071801 regulation of podosome assembly 4/803 13/18722 0.00176053503902257 0.016195623071156 FSCN1/ASAP1/MSN/GSN 4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/803 13/18722 0.00176053503902257 0.016195623071156 THBS1/PTEN/TIMP3/SKIL 4 GO:0035050 embryonic heart tube development 10/803 78/18722 0.0017904154517879 0.0164083180790213 PITX2/HAND2/TBX2/GATA4/PKD2/TGFBR2/YAP1/ENG/NOTCH2/MIB1 10 GO:0060390 regulation of SMAD protein signal transduction 6/803 31/18722 0.00179314924307945 0.0164083180790213 BMP4/SLC2A10/SPTBN1/LRP1/BMPR2/DAB2 6 GO:0032231 regulation of actin filament bundle assembly 12/803 105/18722 0.00179681942862929 0.0164083180790213 SYNPO2/LPAR1/FLNA/PIK3R1/ROCK2/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/CCDC88A/TJP1 12 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 12/803 105/18722 0.00179681942862929 0.0164083180790213 DPYSL3/PALM/FSCN1/CDC42EP5/PIK3R1/ABI2/EPS8/RHOQ/NCKAP1/WASL/CCDC88A/CDC42EP3 12 GO:0042552 myelination 14/803 134/18722 0.00185611812144065 0.0169188390374828 HGF/PMP22/NFASC/TMEM98/CD9/PTEN/CLU/NDRG1/SBF2/LPIN1/PLEC/SKI/MARVELD1/SERINC5 14 GO:0007520 myoblast fusion 7/803 42/18722 0.00188932962956995 0.0171276318782469 ADAMTS5/EHD2/ADAMTS15/ADAM12/CD9/CD81/CAPN2 7 GO:0014912 negative regulation of smooth muscle cell migration 7/803 42/18722 0.00188932962956995 0.0171276318782469 IGFBP3/SLIT2/IGFBP5/PRKG1/LRP1/SEMA6D/TPM1 7 GO:0030574 collagen catabolic process 7/803 42/18722 0.00188932962956995 0.0171276318782469 MMP2/MMP23B/FAP/ADAMTS2/MRC2/CTSK/ITGB1 7 GO:0051897 positive regulation of protein kinase B signaling 13/803 120/18722 0.00192390404603114 0.0174094112041946 F3/IGFBP5/GAS6/THBS1/FGFR1/ANGPT1/IGF2/MFHAS1/AXL/MTDH/ENG/ITGB1/RTN4 13 GO:0046626 regulation of insulin receptor signaling pathway 9/803 66/18722 0.00194157291767121 0.0175057550949524 ENPP1/IGF2/IRS1/PIK3R1/SESN3/SOCS3/PID1/PRKAA1/NUCKS1 9 GO:0071300 cellular response to retinoic acid 9/803 66/18722 0.00194157291767121 0.0175057550949524 COL1A1/WNT2/EPHA3/SERPINF1/PTK7/YAP1/KLF4/SETX/ATM 9 GO:0001824 blastocyst development 12/803 106/18722 0.00194906396286229 0.0175415756657606 HS3ST6/YAP1/CMTM3/KLF4/CAPN2/N4BP2L2/SKIL/RTN4/SBDS/SP3/SLC35E2B/RTF1 12 GO:0006023 aminoglycan biosynthetic process 10/803 79/18722 0.00197285684413917 0.0176918421310753 PDGFRB/HS3ST6/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2/CLTC 10 GO:0050772 positive regulation of axonogenesis 10/803 79/18722 0.00197285684413917 0.0176918421310753 SLIT2/MAP1B/ROBO1/LRP1/NIN/BMPR2/SKIL/PLXNB2/MACF1/GOLGA4 10 GO:0001101 response to acid chemical 14/803 135/18722 0.0019913067510496 0.0178072408364204 COL1A1/COL1A2/COL6A1/PDGFRA/MMP2/COL16A1/COL5A2/COL4A1/CD9/PKD2/SESN3/CAPN2/PLEC/GCLM 14 GO:0046661 male sex differentiation 16/803 165/18722 0.00199286810804705 0.0178072408364204 TCF21/PDGFRA/KITLG/PDGFRB/GATA6/HOXA13/GATA4/FLNA/ACVR2A/SMAD5/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/NCOA1 16 GO:1902743 regulation of lamellipodium organization 8/803 54/18722 0.00200121005053826 0.0178497912557849 PDPN/ENPP2/SLIT2/FSCN1/PIK3R1/ABI2/NCKAP1/FER 8 GO:0060713 labyrinthine layer morphogenesis 5/803 22/18722 0.00205276867490413 0.0182443932496827 BMP5/RSPO3/SOCS3/ZFP36L1/NCOA1 5 GO:0071404 cellular response to low-density lipoprotein particle stimulus 5/803 22/18722 0.00205276867490413 0.0182443932496827 CD36/CES1/CD9/CD81/ITGB1 5 GO:0008361 regulation of cell size 17/803 181/18722 0.00206542654939983 0.0183242291375579 MAP1B/APOE/KCNMA1/SEMA3B/PTEN/NRCAM/LRP1/BMPR2/ABL1/SEMA6D/RTN4/DPYSL2/MSN/RB1CC1/MACF1/GOLGA4/TMEM123 17 GO:0048706 embryonic skeletal system development 13/803 121/18722 0.00207303697325908 0.0183590805482589 COL1A1/PDGFRA/COL11A1/BMP4/OSR2/SLC2A10/ACVR2A/RDH10/EXT1/TWIST1/TGFBR2/SULF2/SP3 13 GO:0019934 cGMP-mediated signaling 6/803 32/18722 0.00212803867594061 0.018671700583817 PDE3A/PRKG1/CD36/THBS1/EDNRB/APOE 6 GO:0035456 response to interferon-beta 6/803 32/18722 0.00212803867594061 0.018671700583817 IFITM2/IFITM3/IFITM1/BST2/CAPN2/IFI16 6 GO:0061036 positive regulation of cartilage development 6/803 32/18722 0.00212803867594061 0.018671700583817 SOX5/GDF6/BMP4/MDK/BMPR2/BMP1 6 GO:1901889 negative regulation of cell junction assembly 6/803 32/18722 0.00212803867594061 0.018671700583817 APOD/THBS1/PTEN/LRP1/ROCK2/DLC1 6 GO:1905476 negative regulation of protein localization to membrane 6/803 32/18722 0.00212803867594061 0.018671700583817 RHOQ/PID1/DAB2/TMEM59/CLTC/HECTD1 6 GO:0007272 ensheathment of neurons 14/803 136/18722 0.00213455060825826 0.018671700583817 HGF/PMP22/NFASC/TMEM98/CD9/PTEN/CLU/NDRG1/SBF2/LPIN1/PLEC/SKI/MARVELD1/SERINC5 14 GO:0008366 axon ensheathment 14/803 136/18722 0.00213455060825826 0.018671700583817 HGF/PMP22/NFASC/TMEM98/CD9/PTEN/CLU/NDRG1/SBF2/LPIN1/PLEC/SKI/MARVELD1/SERINC5 14 GO:2001236 regulation of extrinsic apoptotic signaling pathway 15/803 151/18722 0.0021464113895779 0.0187425695068922 HGF/BMP5/SRPX/SNAI2/BMP4/THBS1/FGFR1/PTEN/TIMP3/YAP1/SKIL/ZMYND11/GCLM/RB1CC1/LTBR 15 GO:0048145 regulation of fibroblast proliferation 10/803 80/18722 0.00216999688860175 0.0189153924590356 PDGFRA/WNT2/DDR2/PDGFRB/GAS6/S100A6/NUPR1/FOSL2/SKI/ZMIZ1 10 GO:0031960 response to corticosteroid 16/803 167/18722 0.00225407883424416 0.0195584152740331 COL1A1/IGFBP2/STC1/SLIT2/FIBIN/SLIT3/SPARC/CLDN1/SERPINF1/MDK/NR3C1/ZFP36L2/ENG/ZFP36L1/SDC1/FOXO3 16 GO:0000768 syncytium formation by plasma membrane fusion 8/803 55/18722 0.00225553324961272 0.0195584152740331 ADAMTS5/EHD2/ADAMTS15/ADAM12/CD9/CD81/SH3PXD2A/CAPN2 8 GO:0140253 cell-cell fusion 8/803 55/18722 0.00225553324961272 0.0195584152740331 ADAMTS5/EHD2/ADAMTS15/ADAM12/CD9/CD81/SH3PXD2A/CAPN2 8 GO:0014020 primary neural tube formation 11/803 94/18722 0.0022739887100305 0.0196842147712016 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/HECTD1 11 GO:0019216 regulation of lipid metabolic process 26/803 331/18722 0.00228502705706245 0.0197454851066089 APOD/BMP5/RARRES2/PDGFRA/PDGFRB/DKK3/SNAI2/PLPP1/APOE/CES1/THRA/RDH10/CD81/IRS1/PDK4/PDE3B/TSPO/LPGAT1/TWIST1/H6PD/LPIN1/CAPN2/PRKAA1/CERS2/NPC2/MBTPS1 26 GO:0021915 neural tube development 15/803 152/18722 0.00228962576657986 0.0197509932044415 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/PKD1/PKD2/TWIST1/ZFP36L1/DLC1/ABL1/PLXNB2/SKI/MIB1/HECTD1 15 GO:0032868 response to insulin 22/803 264/18722 0.00234586047945248 0.0202011405018136 ENPP1/RARRES2/IGF2/IRS1/PTEN/PDK4/PDE3B/ZNF106/PIK3R1/SESN3/SOCS3/ZFP36L1/RHOQ/PTPRA/LPIN1/PID1/PRKAA1/FER/MYO1C/EIF4EBP2/SORT1/NUCKS1 22 GO:0051764 actin crosslink formation 4/803 14/18722 0.00238169774128973 0.0203425170412074 DPYSL3/MARCKS/FLNA/EPS8 4 GO:0072176 nephric duct development 4/803 14/18722 0.00238169774128973 0.0203425170412074 BMP4/GPC3/PKD1/PKD2 4 GO:0072498 embryonic skeletal joint development 4/803 14/18722 0.00238169774128973 0.0203425170412074 BMP4/OSR2/SLC2A10/EXT1 4 GO:1905049 negative regulation of metallopeptidase activity 4/803 14/18722 0.00238169774128973 0.0203425170412074 TIMP1/TIMP3/LRP1/TIMP2 4 GO:0048144 fibroblast proliferation 10/803 81/18722 0.00238267748737768 0.0203425170412074 PDGFRA/WNT2/DDR2/PDGFRB/GAS6/S100A6/NUPR1/FOSL2/SKI/ZMIZ1 10 GO:0010720 positive regulation of cell development 24/803 298/18722 0.00239416549965723 0.0204056567201555 WNT2/SLIT2/PDE3A/PTPRD/MAP1B/BMP4/SERPINE2/BIN1/IL6ST/MYADM/FLNA/SERPINF1/ROBO1/MDK/LRP1/TSPO/NIN/BMPR2/ABL1/SKIL/PLXNB2/NPTN/MACF1/GOLGA4 24 GO:0030522 intracellular receptor signaling pathway 22/803 265/18722 0.00245795066565927 0.020913552933408 TCF21/NR2F1/SNAI2/PLPP1/KANK2/THRA/PIAS2/NCOR2/NR3C1/TIFA/TWIST1/YAP1/DDX17/DAB2/STAT3/ZMIZ1/PUM2/STRN3/ACTN4/CLOCK/TSPAN6/NCOA1 22 GO:1990823 response to leukemia inhibitory factor 11/803 95/18722 0.00247454953939412 0.0210189165305266 MSC/PCOLCE2/EXT1/NRP2/SOCS3/EPS8/KLF4/EIF4A2/ARID5B/RNMT/GCLM 11 GO:0030521 androgen receptor signaling pathway 7/803 44/18722 0.00249201251089736 0.0210876636124322 TCF21/PLPP1/PIAS2/NCOR2/DDX17/DAB2/ZMIZ1 7 GO:0060324 face development 7/803 44/18722 0.00249201251089736 0.0210876636124322 COL1A1/PDGFRA/MMP2/CRISPLD2/RRAS/ARID5B/SKI 7 GO:0003382 epithelial cell morphogenesis 6/803 33/18722 0.00250801935863864 0.0210876636124322 COL15A1/STC1/HOXA13/HEG1/PALLD/EPB41L5 6 GO:0110110 positive regulation of animal organ morphogenesis 6/803 33/18722 0.00250801935863864 0.0210876636124322 WNT2/CSF1/BMP4/SPRY1/ROBO1/FRS2 6 GO:0150117 positive regulation of cell-substrate junction organization 6/803 33/18722 0.00250801935863864 0.0210876636124322 THY1/COL16A1/PIK3R1/ABL1/EPB41L5/MAP4K4 6 GO:1902992 negative regulation of amyloid precursor protein catabolic process 6/803 33/18722 0.00250801935863864 0.0210876636124322 SPON1/APOE/BIN1/CLU/PRNP/RTN4 6 GO:0045926 negative regulation of growth 21/803 249/18722 0.00252593718419401 0.0211423833844928 MEG3/ENPP1/SLIT2/IGFBP5/WFDC1/FHL1/SLIT3/BMP4/SERPINE2/GPC3/CRYAB/GJA1/SEMA3B/PTEN/SOCS2/TGFBR2/BST2/NOTCH2/BMPR2/SEMA6D/RTN4 21 GO:0001759 organ induction 5/803 23/18722 0.00253148874459331 0.0211423833844928 WNT2/BMP4/SPRY1/ROBO1/FRS2 5 GO:0030325 adrenal gland development 5/803 23/18722 0.00253148874459331 0.0211423833844928 PDGFRA/DKK3/MDK/TSPO/ARID5B 5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 5/803 23/18722 0.00253148874459331 0.0211423833844928 CYTL1/CSGALNACT1/CSGALNACT2/UGDH/CHPF2 5 GO:0007346 regulation of mitotic cell cycle 33/803 457/18722 0.00254438754686342 0.0212145757669917 CCND2/FHL1/PDGFRB/SMOC2/HOXA13/BMP4/KANK2/PRKCA/ADAMTS1/GAS1/TTC28/IGF2/CCDC8/HSPA2/MEIS2/PTEN/GPNMB/PKD1/PKD2/EIF4EBP1/DYNLT3/PLCB1/ZFP36L2/ZFP36L1/CDC25B/KLF4/ABL1/TAOK1/TIMP2/KMT2E/NEK7/ATM/USP47 33 GO:0003143 embryonic heart tube morphogenesis 9/803 69/18722 0.00265291564579148 0.0220457290165272 HAND2/TBX2/GATA4/PKD2/TGFBR2/YAP1/ENG/NOTCH2/MIB1 9 GO:0050810 regulation of steroid biosynthetic process 9/803 69/18722 0.00265291564579148 0.0220457290165272 BMP5/DKK3/SNAI2/APOE/CES1/TSPO/H6PD/PRKAA1/MBTPS1 9 GO:0006939 smooth muscle contraction 12/803 110/18722 0.00266745455476703 0.022056266020014 SPX/TBX2/PRKG1/EDNRB/ACTA2/MYLK/KCNMA1/ROCK2/APBB2/SULF2/SLC8A1/ZDHHC21 12 GO:0014812 muscle cell migration 12/803 110/18722 0.00266745455476703 0.022056266020014 IGFBP3/SLIT2/IGFBP5/VTN/PDGFRB/PRKG1/ADAMTS1/PLAU/MDK/LRP1/SEMA6D/TPM1 12 GO:0061387 regulation of extent of cell growth 12/803 110/18722 0.00266745455476703 0.022056266020014 MAP1B/APOE/SEMA3B/NRCAM/LRP1/BMPR2/ABL1/SEMA6D/RTN4/DPYSL2/MACF1/GOLGA4 12 GO:0001823 mesonephros development 11/803 96/18722 0.00268917487908856 0.0221990495813503 TCF21/SLIT2/BMP4/GPC3/OSR2/SPRY1/BASP1/SMAD5/PKD1/PKD2/SDC1 11 GO:0003015 heart process 21/803 251/18722 0.00277850124702552 0.022898524326726 STC1/SPX/DES/FXYD1/TBX2/GATA4/GJA1/BIN1/THRA/FLNA/ATP1B1/EXT1/CAMK2D/SMAD5/EPAS1/CELF2/YAP1/TPM1/SLC8A1/GSN/AKAP13 21 GO:0006949 syncytium formation 8/803 57/18722 0.00283981250508679 0.0233651900171002 ADAMTS5/EHD2/ADAMTS15/ADAM12/CD9/CD81/SH3PXD2A/CAPN2 8 GO:0030833 regulation of actin filament polymerization 16/803 171/18722 0.00286248005641057 0.0235128921931847 SLIT2/ELN/LMOD1/BIN1/CDC42EP5/MYADM/SPTBN1/ABI2/EPS8/NCKAP1/ARHGAP28/WASL/FER/MYO1C/GSN/CDC42EP3 16 GO:0090257 regulation of muscle system process 21/803 252/18722 0.0029125435314067 0.0238847731045951 STC1/MYL9/IGFBP5/HAND2/SPX/PRKG1/GATA4/KCNMA1/BIN1/PRKCA/IL6ST/ATP1B1/CAMK2D/LMCD1/ROCK2/TNFRSF1A/KLF4/TPM1/FOXO3/SLC8A1/ZDHHC21 21 GO:0045123 cellular extravasation 9/803 70/18722 0.00293111290195756 0.023886890211082 VCAM1/THY1/ITGA1/IL1R1/EXT1/MDK/PLCB1/ITGB1/FER 9 GO:0031128 developmental induction 6/803 34/18722 0.00293675565571465 0.023886890211082 WNT2/BMP4/SPRY1/ROBO1/FRS2/HIPK1 6 GO:0035137 hindlimb morphogenesis 6/803 34/18722 0.00293675565571465 0.023886890211082 RSPO2/PITX1/BMP4/GPC3/OSR2/TWIST1 6 GO:0055094 response to lipoprotein particle 6/803 34/18722 0.00293675565571465 0.023886890211082 CD36/APOE/CES1/CD9/CD81/ITGB1 6 GO:0090075 relaxation of muscle 6/803 34/18722 0.00293675565571465 0.023886890211082 PRKG1/KCNMA1/ATP1B1/CAMK2D/SLC8A1/GSN 6 GO:0008584 male gonad development 14/803 141/18722 0.00298455767616553 0.0241967554038395 TCF21/PDGFRA/KITLG/PDGFRB/GATA6/GATA4/FLNA/ACVR2A/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/NCOA1 14 GO:0050921 positive regulation of chemotaxis 14/803 141/18722 0.00298455767616553 0.0241967554038395 RARRES2/F3/SLIT2/CSF1/PDGFRB/SMOC2/GAS6/THBS1/FGFR1/CMKLR1/MDK/BMPR2/WNK1/HSPB1 14 GO:1903131 mononuclear cell differentiation 31/803 426/18722 0.00301299457554499 0.0243876476520573 VCAM1/CSF1/GAS6/BMP4/TMEM176A/TMEM98/TMEM176B/HLA-B/LGALS1/MDK/AXL/B2M/PTPRK/PIK3R1/TGFBR2/ZFP36L2/ZFP36L1/ITGB1/NOTCH2/ABL1/STAT3/KLF6/ZMIZ1/SP3/IFI16/HECTD1/PKNOX1/SOS1/ATM/LTBR/NDFIP1 31 GO:0044706 multi-multicellular organism process 19/803 220/18722 0.00304508490011832 0.0246074445899351 MMP2/IGFBP2/STC1/IGFBP5/PTGFR/COL16A1/SERPINE2/PRLR/TIMP1/GJA1/ACVR2A/TGFBR2/BMPR2/CAPN2/ASH1L/SLC38A2/FBLN1/SP3/LNPEP 19 GO:0009743 response to carbohydrate 21/803 253/18722 0.00305197673655436 0.0246232297871521 COL6A2/MAP1B/GATA4/GAS6/SPARC/THBS1/CAMK2N1/GJA1/LGALS1/SERPINF1/PTEN/LRP1/TGFBR2/TXNIP/ZFP36L1/SIDT2/FOXO3/PRKAA1/MAP4K4/SLC8A1/GCLM 21 GO:0003181 atrioventricular valve morphogenesis 5/803 24/18722 0.0030862610607392 0.0248195123368478 SLIT3/GATA4/TWIST1/TGFBR2/BMPR2 5 GO:0071676 negative regulation of mononuclear cell migration 5/803 24/18722 0.0030862610607392 0.0248195123368478 APOD/BMP5/SLIT2/PLCB1/WASL 5 GO:0031334 positive regulation of protein-containing complex assembly 20/803 237/18722 0.00313666969234634 0.0249977328788814 MAP1B/LMOD1/CD36/FSCN1/BIN1/CDC42EP5/PIEZO1/CLU/NIN/ABI2/NCKAP1/ASAP1/WASL/FER/MYO1C/MSN/GSN/TERF1/ATM/CDC42EP3 20 GO:0048569 post-embryonic animal organ development 4/803 15/18722 0.00313850396754508 0.0249977328788814 MFAP2/MYO1E/KLF4/FBN1 4 GO:0051127 positive regulation of actin nucleation 4/803 15/18722 0.00313850396754508 0.0249977328788814 ABI2/NCKAP1/WASL/GSN 4 GO:0060766 negative regulation of androgen receptor signaling pathway 4/803 15/18722 0.00313850396754508 0.0249977328788814 TCF21/PIAS2/NCOR2/DAB2 4 GO:0072075 metanephric mesenchyme development 4/803 15/18722 0.00313850396754508 0.0249977328788814 TCF21/PDGFRB/BASP1/PKD2 4 GO:0072224 metanephric glomerulus development 4/803 15/18722 0.00313850396754508 0.0249977328788814 TCF21/PDGFRA/PDGFRB/LAMB2 4 GO:0018208 peptidyl-proline modification 8/803 58/18722 0.00317300637918527 0.0251994048925573 P4HA2/FKBP7/FKBP10/PPIC/EGLN3/CRTAP/FKBP9/FKBP14 8 GO:0035270 endocrine system development 13/803 127/18722 0.00318072007776124 0.0251994048925573 BMP5/PDGFRA/PITX2/DKK3/GATA6/PITX1/BMP4/THRA/MDK/TSPO/SIDT2/ARID5B/CLOCK 13 GO:0007009 plasma membrane organization 14/803 142/18722 0.0031840403293845 0.0251994048925573 COL5A1/EHD2/PLSCR4/BIN1/CD9/SPTBN1/PTEN/CLU/NDRG1/STX2/PLEC/ASAP1/WASL/GSN 14 GO:0046546 development of primary male sexual characteristics 14/803 142/18722 0.0031840403293845 0.0251994048925573 TCF21/PDGFRA/KITLG/PDGFRB/GATA6/GATA4/FLNA/ACVR2A/NUPR1/SDC1/ATRX/ARID5B/FNDC3A/NCOA1 14 GO:0003208 cardiac ventricle morphogenesis 9/803 71/18722 0.00323183587384589 0.0254220392597964 HAND2/COL11A1/GATA4/HEG1/TGFBR3/TGFBR2/ENG/TPM1/JAG1 9 GO:0043550 regulation of lipid kinase activity 9/803 71/18722 0.00323183587384589 0.0254220392597964 PDGFRA/PDGFRB/CD81/IRS1/PIK3R1/SOCS2/CISH/SOCS3/KLF4 9 GO:0001974 blood vessel remodeling 7/803 46/18722 0.00323256576227655 0.0254220392597964 RSPO3/FLNA/EXT1/AXL/EPAS1/BMPR2/JAG1 7 GO:0061462 protein localization to lysosome 7/803 46/18722 0.00323256576227655 0.0254220392597964 CD81/CLU/ROCK2/SCARB2/GPR137B/RTN4/SORT1 7 GO:0051962 positive regulation of nervous system development 22/803 272/18722 0.00337654978734302 0.0265125625821926 WNT2/SLIT2/FLRT3/PTPRD/MAP1B/SERPINE2/AMIGO2/BIN1/IL6ST/SERPINF1/ROBO1/MDK/LRP1/TSPO/NIN/BMPR2/SKIL/PLXNB2/NPTN/CLSTN1/MACF1/GOLGA4 22 GO:0031076 embryonic camera-type eye development 6/803 35/18722 0.00341797487271829 0.026711634350115 TBX2/RDH10/TWIST1/FRS2/SP3/HIPK1 6 GO:0034405 response to fluid shear stress 6/803 35/18722 0.00341797487271829 0.026711634350115 PDGFRB/GJA1/PKD1/PKD2/KLF4/PLEC 6 GO:1905207 regulation of cardiocyte differentiation 6/803 35/18722 0.00341797487271829 0.026711634350115 GATA6/GATA4/BMP4/PRICKLE1/EFNB2/FRS2 6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 8/803 59/18722 0.00353579223672732 0.0275766742663544 PDGFRA/PDGFRB/IRS1/PIK3R1/SOCS2/CISH/SOCS3/KLF4 8 GO:0001736 establishment of planar polarity 9/803 72/18722 0.00355631800105613 0.0275766742663544 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/DAAM1 9 GO:0007164 establishment of tissue polarity 9/803 72/18722 0.00355631800105613 0.0275766742663544 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/DAAM1 9 GO:0030032 lamellipodium assembly 9/803 72/18722 0.00355631800105613 0.0275766742663544 SLIT2/FSCN1/PIK3R1/ITGB1/ABI2/NCKAP1/VCL/FER/CCDC88A 9 GO:0035567 non-canonical Wnt signaling pathway 9/803 72/18722 0.00355631800105613 0.0275766742663544 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/DAAM1 9 GO:0052126 movement in host environment 16/803 175/18722 0.00360093747705995 0.027879307858107 GAS6/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ITGB1/SCARB2/TPCN1/FUCA2/GSN 16 GO:0014065 phosphatidylinositol 3-kinase signaling 14/803 144/18722 0.00361576598655438 0.0279507119518762 DCN/HGF/PDGFRA/PDGFRB/PREX2/SERPINE2/FGFR1/ANGPT1/IRS1/PTEN/PIK3R1/TWIST1/ZFP36L1/KLF4 14 GO:0007498 mesoderm development 13/803 129/18722 0.00364232829400876 0.0279927894955015 BMP4/GJA1/TWSG1/ACVR2A/EXT1/MEST/YAP1/ZFP36L1/ITGB1/KLF4/BMPR2/PRKAR1A/EPB41L5 13 GO:0014911 positive regulation of smooth muscle cell migration 7/803 47/18722 0.00366050917590593 0.0279927894955015 IGFBP5/VTN/PDGFRB/ADAMTS1/MDK/LRP1/SEMA6D 7 GO:0042311 vasodilation 7/803 47/18722 0.00366050917590593 0.0279927894955015 PRKG1/ITGA1/EDNRB/APOE/KCNMA1/GJA1/EXT1 7 GO:0043114 regulation of vascular permeability 7/803 47/18722 0.00366050917590593 0.0279927894955015 SLIT2/PDE3A/AKAP12/APOE/ANGPT1/PLEC/TJP1 7 GO:0045601 regulation of endothelial cell differentiation 7/803 47/18722 0.00366050917590593 0.0279927894955015 BMP4/ROCK2/PLCB1/TNFRSF1A/JAG1/VCL/ZDHHC21 7 GO:0045747 positive regulation of Notch signaling pathway 7/803 47/18722 0.00366050917590593 0.0279927894955015 IL6ST/TSPAN5/ROBO1/YAP1/JAG1/STAT3/ZMIZ1 7 GO:0051489 regulation of filopodium assembly 7/803 47/18722 0.00366050917590593 0.0279927894955015 DPYSL3/PALM/FSCN1/MYO10/PIK3R1/RHOQ/WASL 7 GO:0110020 regulation of actomyosin structure organization 11/803 100/18722 0.00370267421165963 0.02817260773967 LPAR1/PIK3R1/ROCK2/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/CCDC88A/TJP1/AKAP13 11 GO:0001558 regulation of cell growth 30/803 414/18722 0.00370431311303835 0.02817260773967 MEG3/ENPP1/FBLN5/SLIT2/IGFBP5/LTBP4/WFDC1/FHL1/SLIT3/MAP1B/SERPINE2/CRYAB/APOE/GJA1/SEMA3B/NRCAM/CAMK2D/LRP1/SOCS2/CISH/BST2/BMPR2/ABL1/SEMA6D/RTN4/DPYSL2/CLSTN1/MACF1/GOLGA4/USP47 30 GO:0009798 axis specification 10/803 86/18722 0.00371030425752537 0.02817260773967 STC1/PITX2/BMP4/GPC3/BASP1/NOTCH2/PCSK6/FRS2/EPB41L5/SKI 10 GO:1903510 mucopolysaccharide metabolic process 10/803 86/18722 0.00371030425752537 0.02817260773967 DCN/HGF/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2/CLTC 10 GO:0042730 fibrinolysis 5/803 25/18722 0.00372357571208234 0.02817260773967 FAP/PROS1/THBS1/PLAU/SERPING1 5 GO:0048596 embryonic camera-type eye morphogenesis 5/803 25/18722 0.00372357571208234 0.02817260773967 TBX2/TWIST1/FRS2/SP3/HIPK1 5 GO:1903901 negative regulation of viral life cycle 5/803 25/18722 0.00372357571208234 0.02817260773967 IFITM2/IFITM3/IFITM1/BST2/GSN 5 GO:0002573 myeloid leukocyte differentiation 18/803 208/18722 0.00378151703516442 0.0285676423292876 CSF1/KITLG/BMP4/GPC3/PRKCA/CD81/SH3PXD2A/PIK3R1/TGFBR2/ZFP36L1/NOTCH2/FBN1/GPR137B/GLO1/SP3/IFI16/LTBR/NDFIP1 18 GO:0031348 negative regulation of defense response 21/803 258/18722 0.0038359652487224 0.0289351327233432 HGF/WFDC1/APOE/HLA-B/SERPING1/HLA-A/MFHAS1/SERPINF1/HTRA1/MDK/A2M/SOCS3/TNFRSF1A/KLF4/HLA-F/ASH1L/METRNL/IFI16/SERPINB9/NDFIP1/TSPAN6 21 GO:0034284 response to monosaccharide 19/803 225/18722 0.0038974474899544 0.0293102159651774 COL6A2/GATA4/GAS6/SPARC/THBS1/CAMK2N1/GJA1/LGALS1/SERPINF1/PTEN/LRP1/TGFBR2/TXNIP/SIDT2/FOXO3/PRKAA1/MAP4K4/SLC8A1/GCLM 19 GO:0050769 positive regulation of neurogenesis 19/803 225/18722 0.0038974474899544 0.0293102159651774 WNT2/SLIT2/PTPRD/MAP1B/SERPINE2/BIN1/IL6ST/SERPINF1/ROBO1/MDK/LRP1/TSPO/NIN/BMPR2/SKIL/PLXNB2/NPTN/MACF1/GOLGA4 19 GO:0051051 negative regulation of transport 33/803 470/18722 0.00392328630429074 0.0294600986644483 ENPP1/APOD/STC1/SPX/STXBP6/MAP1B/EPHA3/CD36/SERPINE2/THBS1/CRYAB/APOE/ANGPT1/GJA1/BIN1/IRS1/PTEN/RAB23/CAMK2D/PKD2/PXK/TWIST1/SESTD1/BST2/TNFRSF1A/CNN2/PKIG/HLA-F/PID1/PLA2R1/WNK1/MAP4K4/NDFIP1 33 GO:0042306 regulation of protein import into nucleus 8/803 60/18722 0.0039298805031565 0.0294652393815614 APOD/CD36/BMP4/ANGPT1/FLNA/RAB23/PIK3R1/PKIG 8 GO:0010092 specification of animal organ identity 6/803 36/18722 0.00395545264287371 0.0295237827505513 WNT2/BMP4/SPRY1/EXT1/ROBO1/FRS2 6 GO:0010762 regulation of fibroblast migration 6/803 36/18722 0.00395545264287371 0.0295237827505513 DDR2/AKAP12/THBS1/ITGB1/FER/SLC8A1 6 GO:0071402 cellular response to lipoprotein particle stimulus 6/803 36/18722 0.00395545264287371 0.0295237827505513 CD36/APOE/CES1/CD9/CD81/ITGB1 6 GO:0003084 positive regulation of systemic arterial blood pressure 4/803 16/18722 0.00404410654276965 0.0300505442954538 RARRES2/SPX/CAMK2N1/WNK1 4 GO:0070571 negative regulation of neuron projection regeneration 4/803 16/18722 0.00404410654276965 0.0300505442954538 THY1/PTEN/MAP4K4/CERS2 4 GO:2001044 regulation of integrin-mediated signaling pathway 4/803 16/18722 0.00404410654276965 0.0300505442954538 TIMP1/SLC2A10/FLNA/CD63 4 GO:0042542 response to hydrogen peroxide 14/803 146/18722 0.00409405443972879 0.0303312859383176 HGF/COL1A1/PDGFRB/CRYAB/AXL/TXNIP/KLF4/SDC1/ABL1/CAPN2/SETX/FOXO3/PRKAA1/SLC8A1 14 GO:0048813 dendrite morphogenesis 14/803 146/18722 0.00409405443972879 0.0303312859383176 PREX2/PTPRD/SDC2/PTEN/TMEM106B/PDLIM5/RAP2A/ITGB1/ABI2/BTBD3/WASL/VLDLR/KIDINS220/FARP1 14 GO:0002686 negative regulation of leukocyte migration 7/803 48/18722 0.00413016851405481 0.030455102817369 APOD/BMP5/SLIT2/EMILIN1/DPP4/PLCB1/WASL 7 GO:1902003 regulation of amyloid-beta formation 7/803 48/18722 0.00413016851405481 0.030455102817369 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:0021782 glial cell development 12/803 116/18722 0.0041351994800158 0.030455102817369 LAMC3/MXRA8/VIM/CD9/PTEN/LAMB2/MDK/LRP1/CLU/NDRG1/PLEC/SKI 12 GO:0030518 intracellular steroid hormone receptor signaling pathway 12/803 116/18722 0.0041351994800158 0.030455102817369 TCF21/PLPP1/KANK2/PIAS2/NCOR2/NR3C1/YAP1/DDX17/DAB2/ZMIZ1/STRN3/CLOCK 12 GO:0016358 dendrite development 20/803 243/18722 0.00415974218097835 0.0305906703751593 BMP5/PREX2/PRKG1/PTPRD/MAP1B/APOE/SDC2/PTEN/TMEM106B/PDLIM5/RAP2A/ITGB1/ABI2/BTBD3/ASAP1/WASL/VLDLR/KIDINS220/ITSN1/FARP1 20 GO:0050866 negative regulation of cell activation 18/803 210/18722 0.0041814174185792 0.0307047823991692 PDGFRA/EMILIN1/PRKG1/BMP4/SERPINE2/APOE/TWSG1/CD9/GPNMB/MDK/AXL/PRNP/PAG1/PRKAR1A/HLA-F/FER/ATM/NDFIP1 18 GO:0030865 cortical cytoskeleton organization 8/803 61/18722 0.00435701272763184 0.0319471550881946 EHD2/EPB41L2/RND3/ROCK2/FMNL2/RHOQ/NCKAP1/PLEC 8 GO:0001843 neural tube closure 10/803 88/18722 0.00438218034907286 0.0320845098685422 CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/HECTD1 10 GO:0014902 myotube differentiation 12/803 117/18722 0.00443309437162362 0.0322488500265829 ADAMTS5/EHD2/ADAMTS15/ADAM12/CD9/CD81/PIEZO1/CAPN2/PLEC/PLD3/SKI/SORT1 12 GO:0072175 epithelial tube formation 13/803 132/18722 0.00443518527657933 0.0322488500265829 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/CEP290/MIB1/HECTD1 13 GO:0010875 positive regulation of cholesterol efflux 5/803 26/18722 0.00444990148782372 0.0322488500265829 ABCA8/APOE/CES1/LRP1/PLTP 5 GO:0019883 antigen processing and presentation of endogenous antigen 5/803 26/18722 0.00444990148782372 0.0322488500265829 HLA-B/HLA-A/HLA-C/B2M/HLA-F 5 GO:0070102 interleukin-6-mediated signaling pathway 5/803 26/18722 0.00444990148782372 0.0322488500265829 IL6ST/YAP1/STAT3/FER/JAK1 5 GO:1905523 positive regulation of macrophage migration 5/803 26/18722 0.00444990148782372 0.0322488500265829 RARRES2/CSF1/THBS1/CMKLR1/MDK 5 GO:2000050 regulation of non-canonical Wnt signaling pathway 5/803 26/18722 0.00444990148782372 0.0322488500265829 RSPO3/GPC3/MLLT3/ABL1/DAB2 5 GO:0009749 response to glucose 18/803 212/18722 0.00461556435467729 0.0333541411741322 COL6A2/GATA4/GAS6/THBS1/CAMK2N1/GJA1/LGALS1/SERPINF1/PTEN/LRP1/TGFBR2/TXNIP/SIDT2/FOXO3/PRKAA1/MAP4K4/SLC8A1/GCLM 18 GO:0035148 tube formation 14/803 148/18722 0.00462248526901831 0.0333541411741322 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/NFIB/TWIST1/DLC1/ABL1/PLXNB2/SKI/CEP290/MIB1/HECTD1 14 GO:0051384 response to glucocorticoid 14/803 148/18722 0.00462248526901831 0.0333541411741322 IGFBP2/STC1/SLIT2/FIBIN/SLIT3/SPARC/CLDN1/SERPINF1/MDK/NR3C1/ZFP36L2/ZFP36L1/SDC1/FOXO3 14 GO:1903706 regulation of hemopoiesis 27/803 367/18722 0.00467881978278365 0.0337118431169932 CSF1/KITLG/GAS6/BMP4/TMEM176A/TMEM176B/PRKCA/HLA-B/ACVR2A/MEIS2/MDK/AXL/B2M/PIK3R1/TGFBR2/ZFP36L2/ZFP36L1/NOTCH2/FBN1/ABL1/GPR137B/JAG1/FOXO3/STAT3/ZMIZ1/SOS1/NDFIP1 27 GO:0022408 negative regulation of cell-cell adhesion 17/803 196/18722 0.0046991362680966 0.0337606533612819 PRKG1/BMP4/SERPINE2/MYADM/TWSG1/CD9/GPNMB/MDK/PRNP/PAG1/KLF4/PRKAR1A/ABL1/WNK1/JAG1/EPB41L5/NDFIP1 17 GO:0071674 mononuclear cell migration 17/803 196/18722 0.0046991362680966 0.0337606533612819 APOD/BMP5/RARRES2/SLIT2/ECM1/CSF1/GAS6/THBS1/CMKLR1/EXT1/MDK/PLCB1/EPS8/PLEC/WNK1/WASL/MSN 17 GO:0045444 fat cell differentiation 19/803 229/18722 0.00471399302738854 0.03381866076915 ENPP1/RARRES2/PDGFRA/RUNX1T1/GDF6/CMKLR1/STEAP4/ZADH2/PLCB1/YAP1/ZFP36L2/ZFP36L1/KLF4/TMEM120A/METRNL/JAG1/ARID5B/AAMDC/SORT1 19 GO:0030203 glycosaminoglycan metabolic process 12/803 118/18722 0.00474792344125642 0.0339951665139752 DCN/HGF/PDGFRB/HS3ST6/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2/CLTC 12 GO:0060606 tube closure 10/803 89/18722 0.00475223246294438 0.0339951665139752 CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/HECTD1 10 GO:0016525 negative regulation of angiogenesis 14/803 149/18722 0.00490665917511204 0.0350495739929923 DCN/CREB3L1/EMILIN1/ISM1/SPARC/THBS1/ADAMTS1/COL4A2/SERPINF1/HSPG2/PDE3B/ROCK2/SPRED1/KLF4 14 GO:0009799 specification of symmetry 13/803 134/18722 0.0050369867887461 0.0359290645617855 PITX2/HAND2/TBX2/BICC1/GATA4/BMP4/ACVR2A/PKD2/TGFBR2/ENG/NOTCH2/PCSK6/MIB1 13 GO:0038065 collagen-activated signaling pathway 4/803 17/18722 0.0051110863066987 0.0361473423052479 COL1A1/DDR2/COL4A1/COL4A2 4 GO:0043117 positive regulation of vascular permeability 4/803 17/18722 0.0051110863066987 0.0361473423052479 PDE3A/APOE/ANGPT1/TJP1 4 GO:0055119 relaxation of cardiac muscle 4/803 17/18722 0.0051110863066987 0.0361473423052479 ATP1B1/CAMK2D/SLC8A1/GSN 4 GO:0060977 coronary vasculature morphogenesis 4/803 17/18722 0.0051110863066987 0.0361473423052479 HAND2/PDGFRB/TGFBR3/SPRED1 4 GO:0061298 retina vasculature development in camera-type eye 4/803 17/18722 0.0051110863066987 0.0361473423052479 PDGFRA/PDGFRB/COL4A1/BMPR2 4 GO:0070593 dendrite self-avoidance 4/803 17/18722 0.0051110863066987 0.0361473423052479 NEXN/PALLD/EXT1/NPTN 4 GO:0010665 regulation of cardiac muscle cell apoptotic process 7/803 50/18722 0.00520465725144189 0.0364645113593146 HAND2/GATA4/PTEN/CAMK2D/MDK/NUPR1/CAPN2 7 GO:0060688 regulation of morphogenesis of a branching structure 7/803 50/18722 0.00520465725144189 0.0364645113593146 HGF/FGF7/WNT2/BMP4/MDK/ABL1/RTN4 7 GO:0021537 telencephalon development 20/803 248/18722 0.00521099055833336 0.0364645113593146 COL3A1/SLIT2/BMP4/FLNA/NFIB/PTEN/EXT1/ROBO1/MDK/LRP1/PLCB1/NIN/LAMB1/BTBD3/SLC38A2/RTN4/SKI/ZMIZ1/SLC8A1/NCOA1 20 GO:0009595 detection of biotic stimulus 6/803 38/18722 0.00521443975114145 0.0364645113593146 SRPX/FAP/HLA-B/HLA-A/TSPO/YAP1 6 GO:0010719 negative regulation of epithelial to mesenchymal transition 6/803 38/18722 0.00521443975114145 0.0364645113593146 BMP5/VASN/LDLRAD4/SPRY1/PTEN/SPRED1 6 GO:0032373 positive regulation of sterol transport 6/803 38/18722 0.00521443975114145 0.0364645113593146 ABCA8/APOE/CES1/LRP1/PLTP/ABCA5 6 GO:0032376 positive regulation of cholesterol transport 6/803 38/18722 0.00521443975114145 0.0364645113593146 ABCA8/APOE/CES1/LRP1/PLTP/ABCA5 6 GO:0035136 forelimb morphogenesis 6/803 38/18722 0.00521443975114145 0.0364645113593146 RSPO2/HOXA13/OSR2/RDH10/TWIST1/ATRX 6 GO:0003171 atrioventricular valve development 5/803 27/18722 0.00527164811104333 0.0366589086215649 SLIT3/GATA4/TWIST1/TGFBR2/BMPR2 5 GO:0003401 axis elongation 5/803 27/18722 0.00527164811104333 0.0366589086215649 BMP4/SPRY1/RDH10/PTK7/YAP1 5 GO:0007263 nitric oxide mediated signal transduction 5/803 27/18722 0.00527164811104333 0.0366589086215649 GUCY1A2/CD36/THBS1/APOE/DDAH2 5 GO:0032967 positive regulation of collagen biosynthetic process 5/803 27/18722 0.00527164811104333 0.0366589086215649 CREB3L1/PDGFRB/BMP4/VIM/ENG 5 GO:0001947 heart looping 8/803 63/18722 0.00531751118030447 0.0368237649236085 HAND2/TBX2/GATA4/PKD2/TGFBR2/ENG/NOTCH2/MIB1 8 GO:0032233 positive regulation of actin filament bundle assembly 8/803 63/18722 0.00531751118030447 0.0368237649236085 SYNPO2/LPAR1/FLNA/ROCK2/SORBS3/ABL1/TPM1/CCDC88A 8 GO:1904589 regulation of protein import 8/803 63/18722 0.00531751118030447 0.0368237649236085 APOD/CD36/BMP4/ANGPT1/FLNA/RAB23/PIK3R1/PKIG 8 GO:0032271 regulation of protein polymerization 19/803 232/18722 0.00541482753742648 0.0374456728177648 SLIT2/ELN/MAP1B/LMOD1/BIN1/CDC42EP5/MYADM/SPTBN1/NIN/ABI2/EPS8/NCKAP1/ABL1/ARHGAP28/WASL/FER/MYO1C/GSN/CDC42EP3 19 GO:0042098 T cell proliferation 17/803 199/18722 0.00546541460668855 0.0377431540567162 IGFBP2/VCAM1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/CD151/PRKAR1A/ABL1/MSN/SOS1/NDFIP1 17 GO:1903037 regulation of leukocyte cell-cell adhesion 25/803 336/18722 0.00551104598400843 0.0379962393292046 IGFBP2/VCAM1/THY1/BMP4/IL6ST/TWSG1/IGF2/LGALS1/HLA-A/CD81/GPNMB/MDK/DPP4/B2M/NFAT5/PRNP/PAG1/TGFBR2/KLF4/MAP3K8/PRKAR1A/WNK1/ZMIZ1/ZDHHC21/NDFIP1 25 GO:2000181 negative regulation of blood vessel morphogenesis 14/803 151/18722 0.00551730390580508 0.0379962393292046 DCN/CREB3L1/EMILIN1/ISM1/SPARC/THBS1/ADAMTS1/COL4A2/SERPINF1/HSPG2/PDE3B/ROCK2/SPRED1/KLF4 14 GO:0050808 synapse organization 30/803 426/18722 0.00555031813195207 0.0381708775253973 NFASC/FLRT3/PDZRN3/PTPRD/MAP1B/PALM/SPARC/AMIGO2/APOE/NFIA/COL4A1/EFNB2/FLNA/PTEN/LAMB2/NRCAM/PDLIM5/NRP2/PRNP/APBB2/NDRG1/ABI2/PPFIBP1/ABL1/PLXNB2/NPTN/WASL/CLSTN1/ITSN1/FARP1 30 GO:0051492 regulation of stress fiber assembly 10/803 91/18722 0.0055657126549376 0.0382240265806045 LPAR1/PIK3R1/ROCK2/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/CCDC88A/TJP1 10 GO:0048644 muscle organ morphogenesis 9/803 77/18722 0.00558004238149767 0.0382697267044668 WNT2/COL11A1/EFEMP2/HEG1/MYLK/TGFBR3/ENG/TPM1/ARID5B 9 GO:0022409 positive regulation of cell-cell adhesion 22/803 284/18722 0.0056161106755159 0.0384641865770911 PDPN/IGFBP2/VCAM1/THY1/PLPP3/IL6ST/MYO10/IGF2/LGALS1/HLA-A/CD81/PIEZO1/MDK/DPP4/B2M/NFAT5/TGFBR2/MAP3K8/PLAUR/ZMIZ1/TJP1/JAK1 22 GO:0043401 steroid hormone mediated signaling pathway 13/803 136/18722 0.00570258895380685 0.0390028923507283 TCF21/BMP4/PLPP1/KANK2/PIAS2/NCOR2/NR3C1/YAP1/DDX17/DAB2/ZMIZ1/STRN3/CLOCK 13 GO:0030038 contractile actin filament bundle assembly 11/803 106/18722 0.00577227548873356 0.039264073106174 ELN/LPAR1/PIK3R1/ROCK2/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/CCDC88A/TJP1 11 GO:0043149 stress fiber assembly 11/803 106/18722 0.00577227548873356 0.039264073106174 ELN/LPAR1/PIK3R1/ROCK2/SORBS3/DLC1/ABL1/ARHGAP28/TPM1/CCDC88A/TJP1 11 GO:0046620 regulation of organ growth 11/803 106/18722 0.00577227548873356 0.039264073106174 WNT2/TBX2/GATA6/MAEL/GJA1/IGF2/TGFBR3/PTEN/BASP1/TGFBR2/YAP1 11 GO:1905477 positive regulation of protein localization to membrane 11/803 106/18722 0.00577227548873356 0.039264073106174 EPHA3/SPTBN1/CD81/LRP1/PIK3R1/PRNP/ITGB1/SLC5A3/AP2B1/STOM/MYO1C 11 GO:0001838 embryonic epithelial tube formation 12/803 121/18722 0.00580076513746515 0.0392837431656387 BMP5/CTHRC1/BMP4/PRICKLE1/PTK7/TWIST1/DLC1/ABL1/PLXNB2/SKI/MIB1/HECTD1 12 GO:0043500 muscle adaptation 12/803 121/18722 0.00580076513746515 0.0392837431656387 IGFBP5/HAND2/GATA6/PRKCA/IL6ST/CAMK2D/LMCD1/ROCK2/TNFRSF1A/KLF4/FOXO3/GSN 12 GO:0045931 positive regulation of mitotic cell cycle 12/803 121/18722 0.00580076513746515 0.0392837431656387 CCND2/SMOC2/PRKCA/ADAMTS1/HSPA2/MEIS2/EIF4EBP1/DYNLT3/PLCB1/CDC25B/ABL1/KMT2E 12 GO:0009948 anterior/posterior axis specification 7/803 51/18722 0.00581456126278407 0.0392837431656387 BMP4/GPC3/BASP1/PCSK6/FRS2/EPB41L5/SKI 7 GO:0071622 regulation of granulocyte chemotaxis 7/803 51/18722 0.00581456126278407 0.0392837431656387 RARRES2/SLIT2/CSF1/THBS1/CMKLR1/MDK/DPP4 7 GO:1901343 negative regulation of vasculature development 14/803 152/18722 0.00584474951413225 0.0394342639749167 DCN/CREB3L1/EMILIN1/ISM1/SPARC/THBS1/ADAMTS1/COL4A2/SERPINF1/HSPG2/PDE3B/ROCK2/SPRED1/KLF4 14 GO:1900076 regulation of cellular response to insulin stimulus 8/803 64/18722 0.00585448619479307 0.039446578604376 ENPP1/IGF2/IRS1/SOCS3/PID1/PRKAA1/MYO1C/NUCKS1 8 GO:0007618 mating 6/803 39/18722 0.00594360971047896 0.0399930337603888 SERPINE2/EDNRB/THRA/ACVR2A/PTEN/NCOA1 6 GO:0072163 mesonephric epithelium development 10/803 92/18722 0.00601124683695965 0.0403392688143753 TCF21/SLIT2/BMP4/GPC3/SPRY1/BASP1/SMAD5/PKD1/PKD2/SDC1 10 GO:0072164 mesonephric tubule development 10/803 92/18722 0.00601124683695965 0.0403392688143753 TCF21/SLIT2/BMP4/GPC3/SPRY1/BASP1/SMAD5/PKD1/PKD2/SDC1 10 GO:0009952 anterior/posterior pattern specification 17/803 201/18722 0.00603064678001775 0.0404150602757641 WNT2/GATA4/BMP4/GPC3/TSHZ1/ACVR2A/MLLT3/BASP1/LRP6/PCSK6/BMPR2/FRS2/EPB41L5/SKI/HIPK1/MIB1/BPTF 17 GO:0030879 mammary gland development 13/803 137/18722 0.00606075766523981 0.0405623325085714 WNT2/IGFBP5/CSF1/TBX2/BMP4/PRLR/ROBO1/ARHGAP5/NCOR2/SOCS2/TGFBR2/RTN4/NCOA1 13 GO:0070373 negative regulation of ERK1 and ERK2 cascade 9/803 78/18722 0.00607434154624243 0.0405987492621512 EMILIN1/CAMK2N1/SPRY1/PTEN/TIMP3/SPRED1/KLF4/ABL1/FBLN1 9 GO:0001945 lymph vessel development 5/803 28/18722 0.0061951305151401 0.0411852276646514 PDPN/HEG1/SVEP1/PKD1/BMPR2 5 GO:0003156 regulation of animal organ formation 5/803 28/18722 0.0061951305151401 0.0411852276646514 WNT2/BMP4/SPRY1/ROBO1/FRS2 5 GO:0010714 positive regulation of collagen metabolic process 5/803 28/18722 0.0061951305151401 0.0411852276646514 CREB3L1/PDGFRB/BMP4/VIM/ENG 5 GO:0051894 positive regulation of focal adhesion assembly 5/803 28/18722 0.0061951305151401 0.0411852276646514 THY1/COL16A1/ABL1/EPB41L5/MAP4K4 5 GO:0030206 chondroitin sulfate biosynthetic process 4/803 18/18722 0.00635136115337658 0.0418124054816992 CSGALNACT1/CSGALNACT2/UGDH/CHPF2 4 GO:0043116 negative regulation of vascular permeability 4/803 18/18722 0.00635136115337658 0.0418124054816992 SLIT2/PDE3A/AKAP12/ANGPT1 4 GO:0043217 myelin maintenance 4/803 18/18722 0.00635136115337658 0.0418124054816992 PTEN/CLU/NDRG1/PLEC 4 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 4/803 18/18722 0.00635136115337658 0.0418124054816992 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0060602 branch elongation of an epithelium 4/803 18/18722 0.00635136115337658 0.0418124054816992 BMP4/SPRY1/RDH10/YAP1 4 GO:0071800 podosome assembly 4/803 18/18722 0.00635136115337658 0.0418124054816992 FSCN1/ASAP1/MSN/GSN 4 GO:0001819 positive regulation of cytokine production 32/803 467/18722 0.00635655903632731 0.0418124054816992 LUM/HGF/F3/SPON2/GATA6/GATA4/CD36/AKAP12/THBS1/IL1R1/HEG1/IL6ST/SPTBN1/HLA-A/CD81/MDK/LRP1/B2M/CLU/PIK3R1/ROCK2/AGPAT2/PLCB1/TWIST1/SULF2/ABL1/HLA-F/PLA2R1/STAT3/IFI16/HSPB1/BTN3A2 32 GO:0033674 positive regulation of kinase activity 32/803 467/18722 0.00635655903632731 0.0418124054816992 CCND2/PDGFRA/DDR2/CSF1/KITLG/PDGFRB/EPHA3/GAS6/THBS1/FGFR1/ANGPT1/PRLR/IGF2/CD81/IRS1/ROBO1/PKD1/AXL/CLU/PKD2/PRNP/TGFBR2/CDC25B/BMPR2/ABL1/TAOK1/DSTYK/WNK1/CCDC88A/VLDLR/COPS8/AKAP13 32 GO:0070613 regulation of protein processing 8/803 65/18722 0.00643171567893685 0.0420958051141908 SPON1/SERPINE2/THBS1/TMEM98/GAS1/PRNP/TMEM59/GSN 8 GO:0072577 endothelial cell apoptotic process 8/803 65/18722 0.00643171567893685 0.0420958051141908 CD248/GAS6/THBS1/ANGPT1/BMPR2/ABL1/FOXO3/HIPK1 8 GO:1905330 regulation of morphogenesis of an epithelium 8/803 65/18722 0.00643171567893685 0.0420958051141908 HGF/FGF7/WNT2/TBX2/BMP4/GJA1/MDK/ABL1 8 GO:0009746 response to hexose 18/803 219/18722 0.00643637794802684 0.0420958051141908 COL6A2/GATA4/GAS6/THBS1/CAMK2N1/GJA1/LGALS1/SERPINF1/PTEN/LRP1/TGFBR2/TXNIP/SIDT2/FOXO3/PRKAA1/MAP4K4/SLC8A1/GCLM 18 GO:0008217 regulation of blood pressure 16/803 186/18722 0.006470700813097 0.0420958051141908 COL1A2/RARRES2/SPX/GAS6/EDNRB/ACTA2/CAMK2N1/GJA1/ECE1/ANPEP/EXT1/BMPR2/TPM1/WNK1/NAV2/LNPEP 16 GO:0120032 regulation of plasma membrane bounded cell projection assembly 16/803 186/18722 0.006470700813097 0.0420958051141908 SLIT2/DPYSL3/PALM/FSCN1/CDC42EP5/MYO10/PIK3R1/YAP1/ABI2/EPS8/RHOQ/NCKAP1/WASL/FER/CCDC88A/CDC42EP3 16 GO:0010662 regulation of striated muscle cell apoptotic process 7/803 52/18722 0.00647631686040107 0.0420958051141908 HAND2/GATA4/PTEN/CAMK2D/MDK/NUPR1/CAPN2 7 GO:0043277 apoptotic cell clearance 7/803 52/18722 0.00647631686040107 0.0420958051141908 GAS6/CD36/THBS1/MFGE8/C2/LRP1/AXL 7 GO:0048260 positive regulation of receptor-mediated endocytosis 7/803 52/18722 0.00647631686040107 0.0420958051141908 VTN/ANGPT1/CD63/B2M/CLU/DAB2/WASL 7 GO:0097306 cellular response to alcohol 10/803 93/18722 0.00648407106452036 0.0420958051141908 PTGFR/ADCY3/CES1/PTGER2/PTEN/GNAI1/LRP6/KLF4/FOXO3/PRKAA1 10 GO:0060420 regulation of heart growth 9/803 79/18722 0.00660167529365569 0.0428035799924152 WNT2/TBX2/GATA6/GJA1/TGFBR3/PTEN/BASP1/TGFBR2/YAP1 9 GO:0042110 T cell activation 33/803 487/18722 0.00664224376871013 0.0429114781009788 IGFBP2/VCAM1/THY1/BMP4/TMEM98/IL6ST/TWSG1/IGF2/LGALS1/HLA-A/CD81/GPNMB/MDK/DPP4/B2M/PTPRK/PRNP/PAG1/TGFBR2/ZFP36L2/ZFP36L1/MAP3K8/CD151/PRKAR1A/ABL1/STAT3/ZMIZ1/MSN/SP3/GSN/PKNOX1/SOS1/NDFIP1 33 GO:0051701 biological process involved in interaction with host 17/803 203/18722 0.00664244231813705 0.0429114781009788 GAS6/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ITGB1/SCARB2/TPCN1/FUCA2/GSN/SERPINB9 17 GO:0071900 regulation of protein serine/threonine kinase activity 26/803 359/18722 0.00664413579902841 0.0429114781009788 CCND2/TNXB/THY1/KITLG/PDGFRB/BMP4/THBS1/APOE/FGFR1/HEG1/SPRY1/IGF2/CCNG2/PTEN/ROBO1/PKD1/PKD2/LRP6/BMPR2/PRKAR1A/ABL1/PKIG/TAOK1/HIPK3/SLC8A1/AKAP13 26 GO:0071526 semaphorin-plexin signaling pathway 6/803 40/18722 0.00674433043774553 0.0435022400551089 HAND2/FLNA/SEMA3B/NRP2/SEMA6D/PLXNB2 6 GO:0008544 epidermis development 24/803 324/18722 0.00680574733046855 0.043841674663716 FGF7/PITX2/IGFBP5/FST/GATA6/LDB2/BMP4/PPL/EMP1/PALLD/EXT1/SVEP1/APCDD1/ROCK2/AGPAT2/YAP1/TXNIP/ZFP36L1/KLF4/PLEC/FOSL2/JAG1/ZDHHC21/SOS1 24 GO:0001738 morphogenesis of a polarized epithelium 10/803 94/18722 0.0069852713448168 0.0448244053092105 CTHRC1/RSPO3/GPC3/PRICKLE1/MLLT3/PTK7/ABL1/DAB2/MSN/DAAM1 10 GO:0061326 renal tubule development 10/803 94/18722 0.0069852713448168 0.0448244053092105 TCF21/BMP4/PROM1/GPC3/COL4A1/PKD1/PKD2/YAP1/NOTCH2/JAG1 10 GO:1990830 cellular response to leukemia inhibitory factor 10/803 94/18722 0.0069852713448168 0.0448244053092105 MSC/PCOLCE2/NRP2/SOCS3/EPS8/KLF4/EIF4A2/ARID5B/RNMT/GCLM 10 GO:0007368 determination of left/right symmetry 12/803 124/18722 0.00703074823702311 0.0450582399868859 PITX2/HAND2/TBX2/BICC1/GATA4/ACVR2A/PKD2/TGFBR2/ENG/NOTCH2/PCSK6/MIB1 12 GO:0044403 biological process involved in symbiotic interaction 22/803 290/18722 0.00712959467358421 0.0456330668067919 GAS6/APOE/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/APOL1/ITGB1/SCARB2/TPCN1/IGF2R/STOM/FUCA2/GSN/SERPINB9/NUCKS1 22 GO:0060491 regulation of cell projection assembly 16/803 188/18722 0.00715072868004285 0.0457096579470432 SLIT2/DPYSL3/PALM/FSCN1/CDC42EP5/MYO10/PIK3R1/YAP1/ABI2/EPS8/RHOQ/NCKAP1/WASL/FER/CCDC88A/CDC42EP3 16 GO:0007566 embryo implantation 7/803 53/18722 0.00719249419289673 0.04591776702405 MMP2/STC1/PRLR/TIMP1/GJA1/TGFBR2/FBLN1 7 GO:0003309 type B pancreatic cell differentiation 5/803 29/18722 0.00722653531281148 0.0460172478539949 BMP5/GATA6/BMP4/SIDT2/CLOCK 5 GO:0048679 regulation of axon regeneration 5/803 29/18722 0.00722653531281148 0.0460172478539949 FLNA/PTEN/LRP1/KLF4/CERS2 5 GO:1903522 regulation of blood circulation 20/803 256/18722 0.00734135402556571 0.0466887642493248 STC1/SPX/DES/FXYD1/TBX2/GATA4/GJA1/BIN1/PTGER2/THRA/ECE1/FLNA/ATP1B1/CAMK2D/EPAS1/CELF2/BMPR2/TPM1/SLC8A1/ZDHHC21 20 GO:0051403 stress-activated MAPK cascade 19/803 239/18722 0.00738621652007363 0.0468815553083004 HGF/HAND2/GDF6/BMP4/CRYAB/CDC42EP5/MFHAS1/PLCB1/RAP2A/ZFP36L1/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/NBR1/PJA2/RB1CC1/LTBR 19 GO:0045666 positive regulation of neuron differentiation 10/803 95/18722 0.00751594449839593 0.0468815553083004 MAP1B/TCF4/BMP4/FGFR1/PTEN/NRCAM/SOCS2/TIMP2/TCF12/NCOA1 10 GO:0031642 negative regulation of myelination 3/803 10/18722 0.00752211075945454 0.0468815553083004 TMEM98/PTEN/LPIN1 3 GO:0031943 regulation of glucocorticoid metabolic process 3/803 10/18722 0.00752211075945454 0.0468815553083004 BMP5/DKK3/H6PD 3 GO:0034651 cortisol biosynthetic process 3/803 10/18722 0.00752211075945454 0.0468815553083004 BMP5/DKK3/H6PD 3 GO:0042487 regulation of odontogenesis of dentin-containing tooth 3/803 10/18722 0.00752211075945454 0.0468815553083004 CSF1/RSPO2/BMP4 3 GO:0044557 relaxation of smooth muscle 3/803 10/18722 0.00752211075945454 0.0468815553083004 PRKG1/KCNMA1/SLC8A1 3 GO:0060439 trachea morphogenesis 3/803 10/18722 0.00752211075945454 0.0468815553083004 RSPO2/BMP4/TGFBR2 3 GO:0070099 regulation of chemokine-mediated signaling pathway 3/803 10/18722 0.00752211075945454 0.0468815553083004 SLIT2/SLIT3/ROBO1 3 GO:0071803 positive regulation of podosome assembly 3/803 10/18722 0.00752211075945454 0.0468815553083004 FSCN1/ASAP1/MSN 3 GO:0072070 loop of Henle development 3/803 10/18722 0.00752211075945454 0.0468815553083004 PKD1/PKD2/JAG1 3 GO:0097084 vascular associated smooth muscle cell development 3/803 10/18722 0.00752211075945454 0.0468815553083004 EFEMP2/SGCB/ENG 3 GO:1902645 tertiary alcohol biosynthetic process 3/803 10/18722 0.00752211075945454 0.0468815553083004 BMP5/DKK3/H6PD 3 GO:1904350 regulation of protein catabolic process in the vacuole 3/803 10/18722 0.00752211075945454 0.0468815553083004 LAPTM4B/CD81/LRP1 3 GO:2000288 positive regulation of myoblast proliferation 3/803 10/18722 0.00752211075945454 0.0468815553083004 GATA6/MEIS2/MALAT1 3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 3/803 10/18722 0.00752211075945454 0.0468815553083004 ABI2/NCKAP1/WASL 3 GO:0048286 lung alveolus development 6/803 41/18722 0.00762040000552886 0.0474310441288239 TCF21/IGFBP5/GATA6/BMP4/BMPR2/LTBP3 6 GO:0051098 regulation of binding 26/803 363/18722 0.00762930152252644 0.0474310441288239 CTHRC1/SPON1/HAND2/VTN/BMP4/APOE/ANGPT1/BAMBI/RAMP1/ZNF618/TGFBR3/PKD1/LRP1/B2M/TWIST1/RSF1/KLF4/PLAUR/ABL1/ARHGAP28/DAB2/AMFR/EPB41L5/SKI/IFI16/NUCKS1 26 GO:0061371 determination of heart left/right asymmetry 8/803 67/18722 0.00771433243788985 0.0476896628580756 HAND2/TBX2/GATA4/PKD2/TGFBR2/ENG/NOTCH2/MIB1 8 GO:1903317 regulation of protein maturation 8/803 67/18722 0.00771433243788985 0.0476896628580756 SPON1/SERPINE2/THBS1/TMEM98/GAS1/PRNP/TMEM59/GSN 8 GO:0048708 astrocyte differentiation 9/803 81/18722 0.00776103232720342 0.0476896628580756 LAMC3/SERPINE2/BIN1/IL6ST/VIM/LAMB2/LRP1/ABL1/STAT3 9 GO:0071260 cellular response to mechanical stimulus 9/803 81/18722 0.00776103232720342 0.0476896628580756 COL1A1/GJA1/PIEZO1/ENG/TNFRSF1A/CNN2/PLEC/SLC38A2/LTBR 9 GO:0002716 negative regulation of natural killer cell mediated immunity 4/803 19/18722 0.00777611229514951 0.0476896628580756 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0007039 protein catabolic process in the vacuole 4/803 19/18722 0.00777611229514951 0.0476896628580756 LAPTM4B/CD81/TMEM106B/LRP1 4 GO:0010002 cardioblast differentiation 4/803 19/18722 0.00777611229514951 0.0476896628580756 TBX2/GATA6/GATA4/PRICKLE1 4 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 4/803 19/18722 0.00777611229514951 0.0476896628580756 SERPINE2/PTEN/TWIST1/KLF4 4 GO:0060216 definitive hemopoiesis 4/803 19/18722 0.00777611229514951 0.0476896628580756 TGFBR3/ZFP36L2/SP3/HIPK1 4 GO:0061323 cell proliferation involved in heart morphogenesis 4/803 19/18722 0.00777611229514951 0.0476896628580756 PITX2/HAND2/BMP4/BMPR2 4 GO:2000738 positive regulation of stem cell differentiation 4/803 19/18722 0.00777611229514951 0.0476896628580756 SOX5/GATA6/GATA4/LTBP3 4 GO:0060326 cell chemotaxis 23/803 310/18722 0.00780860228540141 0.0478300872174587 CXCL14/HGF/RARRES2/PDGFRA/VCAM1/SLIT2/CSF1/PDGFRB/SMOC2/GAS6/ITGA1/THBS1/EDNRB/LPAR1/FGFR1/CMKLR1/MDK/DPP4/PLEC/WNK1/SBDS/MTUS1/HSPB1 23 GO:0009755 hormone-mediated signaling pathway 16/803 190/18722 0.00788703561811447 0.0482512387630905 TCF21/BMP4/PLPP1/KANK2/PRLR/THRA/PIAS2/NCOR2/NR3C1/YAP1/DDX17/DAB2/ZMIZ1/STRN3/CLOCK/NCOA1 16 GO:0010659 cardiac muscle cell apoptotic process 7/803 54/18722 0.00796566417154587 0.0485535471385424 HAND2/GATA4/PTEN/CAMK2D/MDK/NUPR1/CAPN2 7 GO:0032330 regulation of chondrocyte differentiation 7/803 54/18722 0.00796566417154587 0.0485535471385424 SOX5/GDF6/SNAI2/BMP4/MAF/MDK/LTBP3 7 GO:0060350 endochondral bone morphogenesis 7/803 54/18722 0.00796566417154587 0.0485535471385424 COL1A1/STC1/BMP4/EXT1/SERPINH1/TGFBR2/BMPR2 7 GO:0060047 heart contraction 19/803 241/18722 0.00804552472687177 0.0489804472383182 STC1/SPX/DES/FXYD1/TBX2/GATA4/GJA1/BIN1/THRA/FLNA/ATP1B1/EXT1/CAMK2D/SMAD5/EPAS1/CELF2/TPM1/SLC8A1/GSN 19 GO:0048639 positive regulation of developmental growth 15/803 174/18722 0.00806054297692548 0.0490120332718908 WNT2/CSF1/TBX2/GATA6/MAP1B/IGF2/TGFBR3/BASP1/LRP1/PLCB1/TGFBR2/YAP1/BMPR2/MACF1/GOLGA4 15 GO:0003073 regulation of systemic arterial blood pressure 10/803 96/18722 0.00807719677971074 0.0490534752054053 RARRES2/SPX/GAS6/CAMK2N1/GJA1/ECE1/BMPR2/TPM1/WNK1/NAV2 10 GO:0001938 positive regulation of endothelial cell proliferation 11/803 111/18722 0.00811382894296212 0.0492159989167994 F3/WNT2/ECM1/BMP4/FGFR1/PRKCA/IGF2/MDK/NRP2/BMPR2/STAT3 11 GO:0060351 cartilage development involved in endochondral bone morphogenesis 5/803 30/18722 0.00837188956686498 0.0505354011869113 COL1A1/STC1/EXT1/SERPINH1/TGFBR2 5 GO:0060674 placenta blood vessel development 5/803 30/18722 0.00837188956686498 0.0505354011869113 WNT2/PKD1/PKD2/SOCS3/NOTCH2 5 GO:0061311 cell surface receptor signaling pathway involved in heart development 5/803 30/18722 0.00837188956686498 0.0505354011869113 HAND2/SNAI2/BMP4/NOTCH2/JAG1 5 GO:0070168 negative regulation of biomineral tissue development 5/803 30/18722 0.00837188956686498 0.0505354011869113 ENPP1/ECM1/GAS6/ROCK2/LTBP3 5 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 9/803 82/18722 0.00839587354804845 0.0506188942086693 HGF/BMP5/THBS1/PTEN/TIMP3/PIK3R1/TNFRSF1A/SKIL/SORT1 9 GO:0016485 protein processing 18/803 225/18722 0.00842691122793921 0.0507446610899818 F3/C1R/SPON1/CPXM1/ADAMTS2/SERPINE2/THBS1/TMEM98/GAS1/ECE1/PLAU/PRNP/PCSK6/CAPN2/FAM111A/TMEM59/IFI16/GSN 18 GO:0010591 regulation of lamellipodium assembly 6/803 42/18722 0.00857557840152201 0.0513916272956595 SLIT2/FSCN1/PIK3R1/ABI2/NCKAP1/FER 6 GO:0032965 regulation of collagen biosynthetic process 6/803 42/18722 0.00857557840152201 0.0513916272956595 CREB3L1/PDGFRB/EMILIN1/BMP4/VIM/ENG 6 GO:0045214 sarcomere organization 6/803 42/18722 0.00857557840152201 0.0513916272956595 CFL2/ITGB1/PRKAR1A/PLEC/TPM1/AKAP13 6 GO:1904037 positive regulation of epithelial cell apoptotic process 6/803 42/18722 0.00857557840152201 0.0513916272956595 CD248/THBS1/PLA2R1/FOXO3/SORT1/GSN 6 GO:0010633 negative regulation of epithelial cell migration 11/803 112/18722 0.00865989145488788 0.0518337293926287 DCN/STC1/SLIT2/MCC/THBS1/APOE/SERPINF1/PTEN/SPRED1/PTPRG/KLF4 11 GO:0070252 actin-mediated cell contraction 10/803 97/18722 0.00867014246158289 0.0518337293926287 PDPN/STC1/GATA4/GJA1/BIN1/FLNA/CAMK2D/TPM1/EPB41L5/GSN 10 GO:0032872 regulation of stress-activated MAPK cascade 16/803 192/18722 0.00868281864474654 0.0518473458236003 HGF/HAND2/GDF6/BMP4/MFHAS1/PLCB1/RAP2A/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/NBR1/PJA2/RB1CC1/LTBR 16 GO:0038066 p38MAPK cascade 7/803 55/18722 0.00879839159766114 0.0524119241409062 HGF/HAND2/GDF6/BMP4/MFHAS1/ZFP36L1/PJA2 7 GO:1902991 regulation of amyloid precursor protein catabolic process 7/803 55/18722 0.00879839159766114 0.0524119241409062 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:0007565 female pregnancy 16/803 193/18722 0.00910403085043259 0.0541678971602111 MMP2/IGFBP2/STC1/IGFBP5/COL16A1/PRLR/TIMP1/GJA1/TGFBR2/BMPR2/CAPN2/ASH1L/SLC38A2/FBLN1/SP3/LNPEP 16 GO:1904377 positive regulation of protein localization to cell periphery 8/803 69/18722 0.00918022812285575 0.0544896340972667 EPHA3/EPB41L2/SPTBN1/LRP1/GNAI1/PIK3R1/PRNP/ITGB1 8 GO:1902105 regulation of leukocyte differentiation 21/803 279/18722 0.00918036605961312 0.0544896340972667 CSF1/KITLG/GAS6/BMP4/TMEM176A/TMEM176B/PRKCA/HLA-B/MDK/AXL/PIK3R1/TGFBR2/ZFP36L2/ZFP36L1/NOTCH2/FBN1/ABL1/GPR137B/ZMIZ1/SOS1/NDFIP1 21 GO:0046777 protein autophosphorylation 18/803 227/18722 0.00919089094981976 0.0544896340972667 ENPP1/PDGFRA/THY1/DDR2/PDGFRB/FGFR1/PEAK1/GPNMB/CAMK2D/RAP2A/ENG/RAP2B/ABL1/TAOK1/WNK1/DAPK1/FER/ATM 18 GO:0043502 regulation of muscle adaptation 10/803 98/18722 0.00929590238697464 0.0550467568900897 IGFBP5/HAND2/PRKCA/IL6ST/CAMK2D/LMCD1/ROCK2/TNFRSF1A/KLF4/FOXO3 10 GO:0043691 reverse cholesterol transport 4/803 20/18722 0.00939572594136852 0.0555718737172757 APOE/CES1/CLU/ABCA5 4 GO:0022411 cellular component disassembly 30/803 443/18722 0.00943459036274935 0.055706223238732 PDPN/MMP2/ADAMTS5/FAP/DDR2/MAP1B/PLEKHH2/ADAMTS15/SNAI2/LMOD1/CTSK/FSCN1/PRKCA/LAMC1/SPTBN1/HSPA2/CFL2/LRP1/DPP4/PIK3R1/TSPO/EPS8/LPIN1/TAOK1/SETX/KLC1/MAP4K4/BNIP3L/GSN/RB1CC1 30 GO:0010959 regulation of metal ion transport 28/803 406/18722 0.00944078592794395 0.055706223238732 STC1/FHL1/THY1/PDGFRB/FXYD1/SERPINE2/MYLK/GJA1/BIN1/FLNA/HSPA2/ATP1B1/CASK/PTEN/CD63/CAMK2D/B2M/PKD2/TSPO/PRNP/AHNAK/SESTD1/ITGB1/ABL1/WNK1/STOM/SLC8A1/ACTN4 28 GO:0006022 aminoglycan metabolic process 12/803 129/18722 0.00952735068242505 0.0561209423685036 DCN/HGF/PDGFRB/HS3ST6/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/EXT1/UGDH/CHPF2/CLTC 12 GO:0009410 response to xenobiotic stimulus 31/803 462/18722 0.009533581665889 0.0561209423685036 COL1A1/APOD/IGFBP2/WFDC1/NNMT/PDE3A/GATA6/MAP1B/GATA4/GAS6/LGALS1/PTEN/MDK/B2M/TSPO/AGPAT2/PRNP/TGFBR2/RAP2A/TXNIP/ENG/TIMP2/FOXO3/STAT3/PRKAA1/SLC8A1/GSTM3/GCLM/TERF1/USP47/NCOA1 31 GO:0001709 cell fate determination 6/803 43/18722 0.00961357411992718 0.0564632681985935 TBX2/GATA6/BMP4/NOTCH2/KLF4/JAG1 6 GO:0035115 embryonic forelimb morphogenesis 5/803 31/18722 0.00963703193682373 0.0564632681985935 RSPO2/HOXA13/OSR2/RDH10/TWIST1 5 GO:0060045 positive regulation of cardiac muscle cell proliferation 5/803 31/18722 0.00963703193682373 0.0564632681985935 WNT2/TBX2/GATA6/TGFBR3/YAP1 5 GO:0110150 negative regulation of biomineralization 5/803 31/18722 0.00963703193682373 0.0564632681985935 ENPP1/ECM1/GAS6/ROCK2/LTBP3 5 GO:0010658 striated muscle cell apoptotic process 7/803 56/18722 0.00969322833428552 0.0565268262862545 HAND2/GATA4/PTEN/CAMK2D/MDK/NUPR1/CAPN2 7 GO:0045599 negative regulation of fat cell differentiation 7/803 56/18722 0.00969322833428552 0.0565268262862545 ENPP1/RUNX1T1/ZADH2/YAP1/ZFP36L2/JAG1/SORT1 7 GO:0046622 positive regulation of organ growth 7/803 56/18722 0.00969322833428552 0.0565268262862545 WNT2/TBX2/GATA6/IGF2/TGFBR3/BASP1/YAP1 7 GO:1904645 response to amyloid-beta 7/803 56/18722 0.00969322833428552 0.0565268262862545 MMP2/VCAM1/CD36/GJA1/LRP1/PRNP/FOXO3 7 GO:0048015 phosphatidylinositol-mediated signaling 15/803 178/18722 0.00983706675122306 0.0570118396780418 DCN/HGF/PDGFRA/PDGFRB/PREX2/SERPINE2/FGFR1/ANGPT1/IRS1/PTEN/PIK3R1/PLCB1/TWIST1/ZFP36L1/KLF4 15 GO:0030838 positive regulation of actin filament polymerization 10/803 99/18722 0.00995560249153143 0.0570118396780418 LMOD1/BIN1/CDC42EP5/ABI2/NCKAP1/WASL/FER/MYO1C/GSN/CDC42EP3 10 GO:0060415 muscle tissue morphogenesis 8/803 70/18722 0.00998656557071356 0.0570118396780418 WNT2/COL11A1/EFEMP2/HEG1/MYLK/TGFBR3/ENG/TPM1 8 GO:0070302 regulation of stress-activated protein kinase signaling cascade 16/803 195/18722 0.00999516391087372 0.0570118396780418 HGF/HAND2/GDF6/BMP4/MFHAS1/PLCB1/RAP2A/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/NBR1/PJA2/RB1CC1/LTBR 16 GO:0033157 regulation of intracellular protein transport 18/803 229/18722 0.0100093961254585 0.0570118396780418 APOD/GAS6/CD36/BMP4/ANGPT1/FLNA/CD81/RAB23/PIK3R1/PRNP/PKIG/NPEPPS/SAR1A/STOM/PRKAA1/MYO1C/BNIP3L/CEP290 18 GO:0001867 complement activation, lectin pathway 3/803 11/18722 0.0100165205691866 0.0570118396780418 MFAP4/SERPING1/A2M 3 GO:0002357 defense response to tumor cell 3/803 11/18722 0.0100165205691866 0.0570118396780418 RBMS3/KLF4/DAPK1 3 GO:0030210 heparin biosynthetic process 3/803 11/18722 0.0100165205691866 0.0570118396780418 CSGALNACT1/ANGPT1/EXT1 3 GO:0032329 serine transport 3/803 11/18722 0.0100165205691866 0.0570118396780418 SERINC3/SLC38A2/SERINC5 3 GO:0033632 regulation of cell-cell adhesion mediated by integrin 3/803 11/18722 0.0100165205691866 0.0570118396780418 PIEZO1/DPP4/WNK1 3 GO:0034115 negative regulation of heterotypic cell-cell adhesion 3/803 11/18722 0.0100165205691866 0.0570118396780418 MYADM/KLF4/WNK1 3 GO:0034350 regulation of glial cell apoptotic process 3/803 11/18722 0.0100165205691866 0.0570118396780418 GAS6/AKAP12/PRKCA 3 GO:0034650 cortisol metabolic process 3/803 11/18722 0.0100165205691866 0.0570118396780418 BMP5/DKK3/H6PD 3 GO:0035457 cellular response to interferon-alpha 3/803 11/18722 0.0100165205691866 0.0570118396780418 GAS6/AXL/IFNAR1 3 GO:0061029 eyelid development in camera-type eye 3/803 11/18722 0.0100165205691866 0.0570118396780418 OSR2/TWIST1/SOS1 3 GO:0061314 Notch signaling involved in heart development 3/803 11/18722 0.0100165205691866 0.0570118396780418 SNAI2/NOTCH2/JAG1 3 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 3/803 11/18722 0.0100165205691866 0.0570118396780418 MYADM/KLF4/WNK1 3 GO:0072017 distal tubule development 3/803 11/18722 0.0100165205691866 0.0570118396780418 PKD1/PKD2/JAG1 3 GO:0072497 mesenchymal stem cell differentiation 3/803 11/18722 0.0100165205691866 0.0570118396780418 PDGFRA/SOX5/LTBP3 3 GO:0090030 regulation of steroid hormone biosynthetic process 3/803 11/18722 0.0100165205691866 0.0570118396780418 BMP5/DKK3/H6PD 3 GO:1901862 negative regulation of muscle tissue development 3/803 11/18722 0.0100165205691866 0.0570118396780418 IGFBP5/BMP4/TWIST1 3 GO:0019058 viral life cycle 23/803 317/18722 0.0100621709782862 0.0572063677283181 GAS6/APOE/NFIA/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ROCK2/BST2/ITGB1/SCARB2/TPCN1/STOM/FAM111A/IFI16/GSN/NUCKS1 23 GO:0015918 sterol transport 12/803 130/18722 0.0101003665990691 0.0573581182949411 ABCA8/CD36/APOE/CES1/LRP1/PLTP/CLU/TSPO/LRP6/OSBPL1A/NPC2/ABCA5 12 GO:0031098 stress-activated protein kinase signaling cascade 19/803 247/18722 0.0103134095051991 0.0585013194458736 HGF/HAND2/GDF6/BMP4/CRYAB/CDC42EP5/MFHAS1/PLCB1/RAP2A/ZFP36L1/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/NBR1/PJA2/RB1CC1/LTBR 19 GO:0001936 regulation of endothelial cell proliferation 15/803 179/18722 0.0103261834240785 0.0585072165368812 F3/WNT2/ECM1/BMP4/SPARC/THBS1/APOE/FGFR1/GJA1/PRKCA/IGF2/MDK/NRP2/BMPR2/STAT3 15 GO:0070661 leukocyte proliferation 23/803 318/18722 0.0104232286290697 0.0589900317191161 IGFBP2/VCAM1/CSF1/KITLG/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/CLU/PRNP/TGFBR2/BST2/CD151/PRKAR1A/ABL1/PURA/MSN/SOS1/ATM/NDFIP1 23 GO:0043393 regulation of protein binding 16/803 196/18722 0.010465921923565 0.0591644974046431 CTHRC1/SPON1/VTN/BMP4/APOE/ANGPT1/BAMBI/RAMP1/TGFBR3/PKD1/LRP1/B2M/ABL1/DAB2/AMFR/EPB41L5 16 GO:0098773 skin epidermis development 9/803 85/18722 0.0105380901177062 0.059505002635202 FGF7/IGFBP5/FST/GATA6/LDB2/EXT1/APCDD1/ZDHHC21/SOS1 9 GO:0034205 amyloid-beta formation 7/803 57/18722 0.0106527065503733 0.0599485269302048 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:0061756 leukocyte adhesion to vascular endothelial cell 7/803 57/18722 0.0106527065503733 0.0599485269302048 VCAM1/EXT1/MDK/NFAT5/ITGB1/KLF4/ZDHHC21 7 GO:1900024 regulation of substrate adhesion-dependent cell spreading 7/803 57/18722 0.0106527065503733 0.0599485269302048 PDPN/MYADM/FLNA/MDK/ABL1/FBLN1/ACTN4 7 GO:0001889 liver development 13/803 147/18722 0.0107169364133134 0.0602247735021637 HGF/GATA6/CLDN1/TGFBR3/PKD1/MDK/PKD2/SULF2/NOTCH2/IGF2R/ARID5B/SP3/RB1CC1 13 GO:0002066 columnar/cuboidal epithelial cell development 6/803 44/18722 0.0107380312160898 0.0602247735021637 BMP5/BMP4/IL6ST/YAP1/SIDT2/CLOCK 6 GO:0060711 labyrinthine layer development 6/803 44/18722 0.0107380312160898 0.0602247735021637 BMP5/WNT2/RSPO3/SOCS3/ZFP36L1/NCOA1 6 GO:0032386 regulation of intracellular transport 24/803 337/18722 0.0107770123267425 0.0603754870349865 APOD/EHD2/MAP1B/GAS6/CD36/BMP4/CRYAB/ANGPT1/GAS1/FLNA/CD81/RAB23/PIK3R1/PRNP/PKIG/NPEPPS/DAB2/SAR1A/STOM/PRKAA1/MYO1C/MSN/BNIP3L/CEP290 24 GO:0003338 metanephros morphogenesis 5/803 32/18722 0.0110275862443947 0.0614341285078791 PDGFRB/BMP4/BASP1/PKD1/PKD2 5 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 5/803 32/18722 0.0110275862443947 0.0614341285078791 THBS1/ZEB2/SLC2A10/TGFBR3/DAB2 5 GO:0035883 enteroendocrine cell differentiation 5/803 32/18722 0.0110275862443947 0.0614341285078791 BMP5/GATA6/BMP4/SIDT2/CLOCK 5 GO:1900745 positive regulation of p38MAPK cascade 5/803 32/18722 0.0110275862443947 0.0614341285078791 HAND2/GDF6/BMP4/MFHAS1/PJA2 5 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 5/803 32/18722 0.0110275862443947 0.0614341285078791 THBS1/ZEB2/SLC2A10/TGFBR3/DAB2 5 GO:0043200 response to amino acid 11/803 116/18722 0.0111334726533178 0.06188237520094 COL1A1/COL1A2/COL6A1/PDGFRA/MMP2/COL16A1/COL5A2/COL4A1/SESN3/CAPN2/GCLM 11 GO:0007350 blastoderm segmentation 4/803 21/18722 0.0112197487327817 0.06188237520094 BASP1/NRP2/PCSK6/FRS2 4 GO:0034035 purine ribonucleoside bisphosphate metabolic process 4/803 21/18722 0.0112197487327817 0.06188237520094 ENPP1/TPST1/PAPSS2/PAPSS1 4 GO:0046597 negative regulation of viral entry into host cell 4/803 21/18722 0.0112197487327817 0.06188237520094 IFITM2/IFITM3/IFITM1/GSN 4 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 4/803 21/18722 0.0112197487327817 0.06188237520094 ENPP1/TPST1/PAPSS2/PAPSS1 4 GO:0072243 metanephric nephron epithelium development 4/803 21/18722 0.0112197487327817 0.06188237520094 LAMB2/PKD1/PKD2/YAP1 4 GO:0150105 protein localization to cell-cell junction 4/803 21/18722 0.0112197487327817 0.06188237520094 FLNA/VCL/TJP1/JAK1 4 GO:1902307 positive regulation of sodium ion transmembrane transport 4/803 21/18722 0.0112197487327817 0.06188237520094 FXYD1/ATP1B1/WNK1/ACTN4 4 GO:1905209 positive regulation of cardiocyte differentiation 4/803 21/18722 0.0112197487327817 0.06188237520094 GATA6/GATA4/BMP4/EFNB2 4 GO:0035264 multicellular organism growth 12/803 132/18722 0.0113261710311549 0.0623175402978246 CSF1/HEG1/IGF2/EXT1/SOCS2/ZFP36L1/NOTCH2/PLEC/ATRX/ARID5B/STAT3/SOS1 12 GO:0034103 regulation of tissue remodeling 9/803 86/18722 0.0113361430104546 0.0623175402978246 DDR2/HAND2/PRKCA/PDK4/GPNMB/MDK/ROCK2/LTBP3/GPR137B 9 GO:2000117 negative regulation of cysteine-type endopeptidase activity 9/803 86/18722 0.0113361430104546 0.0623175402978246 HGF/GAS6/THBS1/CRYAB/KLF4/PLAUR/IFI16/SERPINB9/USP47 9 GO:0032387 negative regulation of intracellular transport 7/803 58/18722 0.0116793320640658 0.0641334247482735 APOD/MAP1B/CD36/CRYAB/ANGPT1/RAB23/PKIG 7 GO:0001707 mesoderm formation 8/803 72/18722 0.0117553079021875 0.0642675057020911 BMP4/GJA1/TWSG1/ITGB1/KLF4/BMPR2/PRKAR1A/EPB41L5 8 GO:0014743 regulation of muscle hypertrophy 8/803 72/18722 0.0117553079021875 0.0642675057020911 IGFBP5/HAND2/PRKCA/IL6ST/CAMK2D/LMCD1/ROCK2/TNFRSF1A 8 GO:0030330 DNA damage response, signal transduction by p53 class mediator 8/803 72/18722 0.0117553079021875 0.0642675057020911 SNAI2/TWIST1/NDRG1/SPRED1/PLA2R1/ATRX/FOXO3/ATM 8 GO:0055021 regulation of cardiac muscle tissue growth 8/803 72/18722 0.0117553079021875 0.0642675057020911 WNT2/TBX2/GATA6/GJA1/TGFBR3/PTEN/TGFBR2/YAP1 8 GO:0030301 cholesterol transport 11/803 117/18722 0.0118287949278332 0.0645984353890212 ABCA8/CD36/APOE/CES1/LRP1/PLTP/CLU/TSPO/LRP6/NPC2/ABCA5 11 GO:0048017 inositol lipid-mediated signaling 15/803 182/18722 0.0119091845049526 0.0649662953410216 DCN/HGF/PDGFRA/PDGFRB/PREX2/SERPINE2/FGFR1/ANGPT1/IRS1/PTEN/PIK3R1/PLCB1/TWIST1/ZFP36L1/KLF4 15 GO:0060421 positive regulation of heart growth 6/803 45/18722 0.0119525168756279 0.0649893665669364 WNT2/TBX2/GATA6/TGFBR3/BASP1/YAP1 6 GO:0071354 cellular response to interleukin-6 6/803 45/18722 0.0119525168756279 0.0649893665669364 IL6ST/YAP1/PID1/STAT3/FER/JAK1 6 GO:1904646 cellular response to amyloid-beta 6/803 45/18722 0.0119525168756279 0.0649893665669364 VCAM1/CD36/GJA1/LRP1/PRNP/FOXO3 6 GO:0009855 determination of bilateral symmetry 12/803 133/18722 0.0119804959216134 0.0650705366722923 PITX2/HAND2/TBX2/BICC1/GATA4/ACVR2A/PKD2/TGFBR2/ENG/NOTCH2/PCSK6/MIB1 12 GO:0060538 skeletal muscle organ development 14/803 166/18722 0.0122849765485068 0.0666516790760119 DCN/TCF21/ELN/MSC/PITX1/IGF2/CFL2/BASP1/TWIST1/NUPR1/DDX17/PLEC/SKI/PRKAA1 14 GO:0016032 viral process 28/803 415/18722 0.0124178605521959 0.0672994051230966 GAS6/APOE/NFIA/EFNB2/IFITM2/CLDN1/IFITM3/LGALS1/ANPEP/CD81/IFITM1/AXL/DPP4/ROCK2/BST2/ITGB1/SCARB2/HCFC2/RSF1/TPCN1/GALNT1/IGF2R/STOM/FAM111A/IFI16/GSN/NUCKS1/CANX 28 GO:0035025 positive regulation of Rho protein signal transduction 5/803 33/18722 0.0125489374739939 0.0677574465867791 COL3A1/PDGFRB/LPAR1/ROBO1/AKAP13 5 GO:0048730 epidermis morphogenesis 5/803 33/18722 0.0125489374739939 0.0677574465867791 FGF7/IGFBP5/FST/EXT1/KLF4 5 GO:0061008 hepaticobiliary system development 13/803 150/18722 0.0125520675082002 0.0677574465867791 HGF/GATA6/CLDN1/TGFBR3/PKD1/MDK/PKD2/SULF2/NOTCH2/IGF2R/ARID5B/SP3/RB1CC1 13 GO:0007613 memory 11/803 118/18722 0.0125567349872009 0.0677574465867791 CCND2/APOE/SERPINF1/PTEN/MDK/PRNP/PLCB1/EIF4EBP2/VLDLR/PJA2/ATXN1 11 GO:0051145 smooth muscle cell differentiation 8/803 73/18722 0.0127213988219463 0.0684977262702208 EFEMP2/TBX2/GATA6/PRDM6/BMP4/EDNRB/SGCB/ENG 8 GO:0072089 stem cell proliferation 8/803 73/18722 0.0127213988219463 0.0684977262702208 KITLG/GJA1/YAP1/ZFP36L1/AGO3/LTBP3/N4BP2L2/FBLN1 8 GO:0009886 post-embryonic animal morphogenesis 3/803 12/18722 0.0129348936897113 0.0688296477448246 MFAP2/FBN1/ATRX 3 GO:0030202 heparin metabolic process 3/803 12/18722 0.0129348936897113 0.0688296477448246 CSGALNACT1/ANGPT1/EXT1 3 GO:0033629 negative regulation of cell adhesion mediated by integrin 3/803 12/18722 0.0129348936897113 0.0688296477448246 SNAI2/PDE3B/WNK1 3 GO:0035739 CD4-positive, alpha-beta T cell proliferation 3/803 12/18722 0.0129348936897113 0.0688296477448246 TWSG1/CD81/TGFBR2 3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 3/803 12/18722 0.0129348936897113 0.0688296477448246 EMILIN1/LDLRAD4/LRP1 3 GO:0060442 branching involved in prostate gland morphogenesis 3/803 12/18722 0.0129348936897113 0.0688296477448246 HOXA13/BMP4/FRS2 3 GO:0070572 positive regulation of neuron projection regeneration 3/803 12/18722 0.0129348936897113 0.0688296477448246 HGF/FLNA/LRP1 3 GO:0070586 cell-cell adhesion involved in gastrulation 3/803 12/18722 0.0129348936897113 0.0688296477448246 MYADM/KLF4/WNK1 3 GO:0072537 fibroblast activation 3/803 12/18722 0.0129348936897113 0.0688296477448246 PDGFRB/AKAP12/GCLM 3 GO:0090331 negative regulation of platelet aggregation 3/803 12/18722 0.0129348936897113 0.0688296477448246 PRKG1/SERPINE2/CD9 3 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 3/803 12/18722 0.0129348936897113 0.0688296477448246 TWSG1/CD81/TGFBR2 3 GO:0010232 vascular transport 9/803 88/18722 0.0130667535101334 0.0694571780400054 SLC22A3/CD36/APOE/GJA1/SLC2A10/SLC16A7/LRP1/SLC5A3/SLC38A2 9 GO:0032496 response to lipopolysaccharide 24/803 343/18722 0.0131552915318735 0.0698533371436864 DCN/VCAM1/PTGFR/LOXL1/SPON2/CD36/AKAP12/SPARC/EDNRB/PLSCR4/GJA1/PRKCA/CLDN1/VIM/TFPI/AXL/MTDH/TSPO/ABL1/CAPN2/SGMS1/LITAF/FER/IFNAR1 24 GO:0002089 lens morphogenesis in camera-type eye 4/803 22/18722 0.0132568554123101 0.0699649741582606 BMP4/ABI2/SKI/HIPK1 4 GO:0007413 axonal fasciculation 4/803 22/18722 0.0132568554123101 0.0699649741582606 NDN/EPHA3/NRCAM/RTN4 4 GO:0060343 trabecula formation 4/803 22/18722 0.0132568554123101 0.0699649741582606 COL1A1/MMP2/ADAMTS1/TGFBR3 4 GO:0106030 neuron projection fasciculation 4/803 22/18722 0.0132568554123101 0.0699649741582606 NDN/EPHA3/NRCAM/RTN4 4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 6/803 46/18722 0.0132605095426306 0.0699649741582606 CADM3/VCAM1/SCARF2/PTPRD/AMIGO2/ALCAM 6 GO:0032924 activin receptor signaling pathway 6/803 46/18722 0.0132605095426306 0.0699649741582606 FST/GDF6/ACVR2A/TGFBR2/BMPR2/SKI 6 GO:0031667 response to nutrient levels 31/803 474/18722 0.0133777123608527 0.0705087461217882 COL1A1/RARRES2/IGFBP2/STC1/VCAM1/SLC22A3/SPX/MAP1B/SNAI2/GATA4/GAS6/SPARC/KANK2/APOE/C2/PTEN/PDK4/TSPO/EIF4EBP1/SESN3/TGFBR2/BMPR2/PLEC/SLC38A2/SLC39A4/FOXO3/PRKAA1/SLC8A1/IFI16/GCLM/NCOA1 31 GO:0002040 sprouting angiogenesis 15/803 185/18722 0.0136759142685628 0.0720043384826335 SLIT2/ADGRA2/RSPO3/CREB3L1/BMP4/THBS1/ANGPT1/EFNB2/ROBO1/ITGB1/SPRED1/KLF4/ABL1/TJP1/JAK1 15 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 8/803 74/18722 0.0137444018195401 0.0720605546500808 TCF21/KANK2/PIAS2/NCOR2/YAP1/DAB2/STRN3/CLOCK 8 GO:0046323 glucose import 8/803 74/18722 0.0137444018195401 0.0720605546500808 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/PID1/SORT1 8 GO:0048332 mesoderm morphogenesis 8/803 74/18722 0.0137444018195401 0.0720605546500808 BMP4/GJA1/TWSG1/ITGB1/KLF4/BMPR2/PRKAR1A/EPB41L5 8 GO:0120192 tight junction assembly 8/803 74/18722 0.0137444018195401 0.0720605546500808 SNAI2/GJA1/CLDN1/MTDH/ROCK2/MPDZ/MYO1C/TJP1 8 GO:1901890 positive regulation of cell junction assembly 10/803 104/18722 0.0138027788029303 0.0722906041086242 THY1/COL16A1/FLRT3/PTPRD/AMIGO2/CLDN1/ABL1/EPB41L5/CLSTN1/MAP4K4 10 GO:0002237 response to molecule of bacterial origin 25/803 363/18722 0.0138644374804195 0.0725373402700645 DCN/VCAM1/PTGFR/LOXL1/SPON2/CD36/AKAP12/SPARC/EDNRB/PLSCR4/GJA1/PRKCA/CLDN1/VIM/TFPI/AXL/B2M/MTDH/TSPO/ABL1/CAPN2/SGMS1/LITAF/FER/IFNAR1 25 GO:0071901 negative regulation of protein serine/threonine kinase activity 11/803 120/18722 0.0141141684187712 0.0737114663846658 BMP4/APOE/HEG1/SPRY1/PTEN/LRP6/PRKAR1A/ABL1/PKIG/HIPK3/SLC8A1 11 GO:1900180 regulation of protein localization to nucleus 12/803 136/18722 0.0141184216601195 0.0737114663846658 APOD/CD36/BMP4/TMEM98/ANGPT1/FLNA/MFHAS1/GLIS2/RAB23/PIK3R1/YAP1/PKIG 12 GO:0021543 pallium development 14/803 169/18722 0.0141987069342184 0.0737835042329161 COL3A1/SLIT2/FLNA/PTEN/ROBO1/MDK/LRP1/PLCB1/LAMB1/BTBD3/SLC38A2/RTN4/ZMIZ1/NCOA1 14 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 5/803 34/18722 0.0142062102012835 0.0737835042329161 SNAI2/TWIST1/SPRED1/PLA2R1/ATM 5 GO:0044319 wound healing, spreading of cells 5/803 34/18722 0.0142062102012835 0.0737835042329161 PDPN/COL5A1/FLNA/PTEN/CD151 5 GO:0050931 pigment cell differentiation 5/803 34/18722 0.0142062102012835 0.0737835042329161 ENPP1/KITLG/EDNRB/ZEB2/CD63 5 GO:0090505 epiboly involved in wound healing 5/803 34/18722 0.0142062102012835 0.0737835042329161 PDPN/COL5A1/FLNA/PTEN/CD151 5 GO:0072583 clathrin-dependent endocytosis 6/803 47/18722 0.0146653876450781 0.0760100029088976 AP2B1/DAB2/WASL/CLTC/CANX/ITSN1 6 GO:1900744 regulation of p38MAPK cascade 6/803 47/18722 0.0146653876450781 0.0760100029088976 HGF/HAND2/GDF6/BMP4/MFHAS1/PJA2 6 GO:0042475 odontogenesis of dentin-containing tooth 9/803 90/18722 0.0149861085127546 0.0775916272529537 PDGFRA/HAND2/FST/CSF1/RSPO2/BMP4/ACVR2A/HTRA1/FAM20C 9 GO:0050863 regulation of T cell activation 23/803 329/18722 0.0151277330242217 0.0782436481937444 IGFBP2/VCAM1/THY1/BMP4/IL6ST/TWSG1/IGF2/LGALS1/HLA-A/CD81/GPNMB/MDK/DPP4/B2M/PRNP/PAG1/TGFBR2/MAP3K8/PRKAR1A/ABL1/ZMIZ1/SOS1/NDFIP1 23 GO:0003323 type B pancreatic cell development 4/803 23/18722 0.0155148273423557 0.0797494114731812 BMP5/BMP4/SIDT2/CLOCK 4 GO:0035988 chondrocyte proliferation 4/803 23/18722 0.0155148273423557 0.0797494114731812 STC1/DDR2/EXT1/BMPR2 4 GO:0036303 lymph vessel morphogenesis 4/803 23/18722 0.0155148273423557 0.0797494114731812 PDPN/SVEP1/PKD1/BMPR2 4 GO:0051882 mitochondrial depolarization 4/803 23/18722 0.0155148273423557 0.0797494114731812 DCN/TSPO/ABL1/GCLM 4 GO:0060487 lung epithelial cell differentiation 4/803 23/18722 0.0155148273423557 0.0797494114731812 GATA6/THRA/NFIB/YAP1 4 GO:0060575 intestinal epithelial cell differentiation 4/803 23/18722 0.0155148273423557 0.0797494114731812 GATA6/GATA4/IL6ST/YAP1 4 GO:0042129 regulation of T cell proliferation 14/803 171/18722 0.0155968863642301 0.0800062504239208 IGFBP2/VCAM1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/PRKAR1A/SOS1/NDFIP1 14 GO:0046890 regulation of lipid biosynthetic process 14/803 171/18722 0.0155968863642301 0.0800062504239208 BMP5/DKK3/SNAI2/APOE/CES1/RDH10/PDK4/TSPO/LPGAT1/H6PD/LPIN1/CAPN2/PRKAA1/MBTPS1 14 GO:0032273 positive regulation of protein polymerization 12/803 138/18722 0.0156972272353913 0.0803556211454425 MAP1B/LMOD1/BIN1/CDC42EP5/NIN/ABI2/NCKAP1/WASL/FER/MYO1C/GSN/CDC42EP3 12 GO:0055076 transition metal ion homeostasis 12/803 138/18722 0.0156972272353913 0.0803556211454425 CYBRD1/BDH2/SLC39A13/STEAP4/SLC39A6/EPAS1/B2M/SLC40A1/PRNP/FRRS1/SLC39A4/NDFIP1 12 GO:0019932 second-messenger-mediated signaling 22/803 312/18722 0.0157640172945544 0.0806023910948095 VCAM1/PTGFR/GUCY1A2/PDE3A/PRKG1/CD36/THBS1/EDNRB/APOE/CMKLR1/ATP1B1/CAMK2D/PDE3B/GNAI1/LMCD1/NFAT5/PRNP/MCTP2/PRKAA1/DDAH2/EIF4EBP2/SLC8A1 22 GO:0045165 cell fate commitment 19/803 258/18722 0.0157777644822571 0.0806023910948095 PDPN/WNT2/SOX5/TBX2/GATA6/HOXA13/PITX1/GATA4/BMP4/GAS1/EXT1/SMAD5/EPAS1/ITGB1/NOTCH2/KLF4/JAG1/STAT3/RTF1 19 GO:0045860 positive regulation of protein kinase activity 26/803 386/18722 0.015884166231307 0.0808461449760596 CCND2/DDR2/CSF1/KITLG/PDGFRB/GAS6/THBS1/FGFR1/ANGPT1/PRLR/IGF2/ROBO1/PKD1/CLU/PKD2/PRNP/TGFBR2/CDC25B/BMPR2/ABL1/TAOK1/WNK1/CCDC88A/VLDLR/COPS8/AKAP13 26 GO:0006809 nitric oxide biosynthetic process 8/803 76/18722 0.0159683188977102 0.0808461449760596 CD36/CLU/PKD2/TSPO/ROCK2/KLF4/CYB5R3/DDAH2 8 GO:2000379 positive regulation of reactive oxygen species metabolic process 8/803 76/18722 0.0159683188977102 0.0808461449760596 PDGFRB/CD36/THBS1/TSPO/TGFBR2/SLC5A3/PID1/FOXO3 8 GO:0001569 branching involved in blood vessel morphogenesis 5/803 35/18722 0.016004249422711 0.0808461449760596 COL4A1/MDK/TGFBR2/ENG/ABL1 5 GO:0021955 central nervous system neuron axonogenesis 5/803 35/18722 0.016004249422711 0.0808461449760596 CDH11/SLIT2/NFIB/PTEN/NIN 5 GO:0046627 negative regulation of insulin receptor signaling pathway 5/803 35/18722 0.016004249422711 0.0808461449760596 ENPP1/IRS1/SOCS3/PID1/PRKAA1 5 GO:0090504 epiboly 5/803 35/18722 0.016004249422711 0.0808461449760596 PDPN/COL5A1/FLNA/PTEN/CD151 5 GO:0098801 regulation of renal system process 5/803 35/18722 0.016004249422711 0.0808461449760596 STC1/SPX/GAS6/EDNRB/GJA1 5 GO:0001657 ureteric bud development 9/803 91/18722 0.0160200543995882 0.0808461449760596 TCF21/SLIT2/BMP4/GPC3/SPRY1/BASP1/SMAD5/PKD2/SDC1 9 GO:0019935 cyclic-nucleotide-mediated signaling 9/803 91/18722 0.0160200543995882 0.0808461449760596 PDE3A/PRKG1/CD36/THBS1/EDNRB/APOE/PDE3B/GNAI1/EIF4EBP2 9 GO:0060191 regulation of lipase activity 9/803 91/18722 0.0160200543995882 0.0808461449760596 PDGFRA/PDGFRB/LPAR1/FGFR1/LRP1/PCSK6/ABL1/PLA2R1/SORT1 9 GO:0072080 nephron tubule development 9/803 91/18722 0.0160200543995882 0.0808461449760596 TCF21/BMP4/PROM1/GPC3/PKD1/PKD2/YAP1/NOTCH2/JAG1 9 GO:0006665 sphingolipid metabolic process 13/803 155/18722 0.0161379893150699 0.0809650903355941 ENPP2/ELOVL2/ABCA8/PLPP1/PLPP3/SERINC1/SERINC3/SGMS1/PRKAA1/SERINC5/CERS2/CERS6/FADS3 13 GO:0007519 skeletal muscle tissue development 13/803 155/18722 0.0161379893150699 0.0809650903355941 DCN/TCF21/ELN/MSC/PITX1/IGF2/CFL2/TWIST1/NUPR1/DDX17/PLEC/SKI/PRKAA1 13 GO:0003002 regionalization 23/803 331/18722 0.016140572045298 0.0809650903355941 WNT2/PITX2/GATA4/BMP4/GPC3/SPRY1/TSHZ1/ACVR2A/MLLT3/EXT1/BASP1/ROBO1/NRP2/LRP6/NOTCH2/PCSK6/BMPR2/FRS2/EPB41L5/SKI/HIPK1/MIB1/BPTF 23 GO:0033628 regulation of cell adhesion mediated by integrin 6/803 48/18722 0.01617041894951 0.0809650903355941 SNAI2/PLAU/PIEZO1/PDE3B/DPP4/WNK1 6 GO:0090311 regulation of protein deacetylation 6/803 48/18722 0.01617041894951 0.0809650903355941 NDN/NNMT/CAMK2D/SPRED1/SKI/PRKAA1 6 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 6/803 48/18722 0.01617041894951 0.0809650903355941 SRPX/THBS1/PTEN/TIMP3/SKIL/LTBR 6 GO:0008016 regulation of heart contraction 16/803 206/18722 0.0161991684945805 0.0809650903355941 STC1/SPX/DES/FXYD1/TBX2/GATA4/GJA1/BIN1/THRA/FLNA/ATP1B1/CAMK2D/EPAS1/CELF2/TPM1/SLC8A1 16 GO:0003334 keratinocyte development 3/803 13/18722 0.016287201284918 0.0809650903355941 PALLD/PLEC/FOSL2 3 GO:0034309 primary alcohol biosynthetic process 3/803 13/18722 0.016287201284918 0.0809650903355941 BMP5/DKK3/H6PD 3 GO:0048266 behavioral response to pain 3/803 13/18722 0.016287201284918 0.0809650903355941 THBS1/TSPO/CAPN2 3 GO:0048711 positive regulation of astrocyte differentiation 3/803 13/18722 0.016287201284918 0.0809650903355941 SERPINE2/BIN1/IL6ST 3 GO:0061744 motor behavior 3/803 13/18722 0.016287201284918 0.0809650903355941 EXT1/DPP4/PRKAA1 3 GO:1900272 negative regulation of long-term synaptic potentiation 3/803 13/18722 0.016287201284918 0.0809650903355941 APOE/PRNP/ABL1 3 GO:1905907 negative regulation of amyloid fibril formation 3/803 13/18722 0.016287201284918 0.0809650903355941 CRYAB/APOE/CLU 3 GO:2001198 regulation of dendritic cell differentiation 3/803 13/18722 0.016287201284918 0.0809650903355941 TMEM176A/TMEM176B/HLA-B 3 GO:0007588 excretion 7/803 62/18722 0.0165061396508155 0.0818087597405231 STC1/SPX/EDNRB/KCNMA1/CLCN5/MDK/NFAT5 7 GO:0045428 regulation of nitric oxide biosynthetic process 7/803 62/18722 0.0165061396508155 0.0818087597405231 CD36/CLU/PKD2/TSPO/ROCK2/KLF4/DDAH2 7 GO:0046847 filopodium assembly 7/803 62/18722 0.0165061396508155 0.0818087597405231 DPYSL3/PALM/FSCN1/MYO10/PIK3R1/RHOQ/WASL 7 GO:0045598 regulation of fat cell differentiation 12/803 139/18722 0.0165350010396654 0.0818704222281745 ENPP1/RARRES2/RUNX1T1/CMKLR1/ZADH2/YAP1/ZFP36L2/ZFP36L1/METRNL/JAG1/AAMDC/SORT1 12 GO:0051258 protein polymerization 21/803 296/18722 0.0169626532587312 0.083904552726224 SLIT2/ELN/MAP1B/LMOD1/BIN1/CDC42EP5/MYADM/GAS7/SPTBN1/NIN/ABI2/EPS8/NCKAP1/ABL1/ARHGAP28/TTC17/WASL/FER/MYO1C/GSN/CDC42EP3 21 GO:0052372 modulation by symbiont of entry into host 6/803 49/18722 0.0177787505711501 0.0875616540731842 IFITM2/IFITM3/LGALS1/IFITM1/FUCA2/GSN 6 GO:0060964 regulation of gene silencing by miRNA 6/803 49/18722 0.0177787505711501 0.0875616540731842 MAEL/BMP4/KCNQ1OT1/NCOR2/STAT3/PUM2 6 GO:0070741 response to interleukin-6 6/803 49/18722 0.0177787505711501 0.0875616540731842 IL6ST/YAP1/PID1/STAT3/FER/JAK1 6 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/803 49/18722 0.0177787505711501 0.0875616540731842 HGF/BMP5/THBS1/PTEN/TIMP3/SKIL 6 GO:0030224 monocyte differentiation 5/803 36/18722 0.0179476037420396 0.0875616540731842 CSF1/BMP4/ZFP36L1/SP3/IFI16 5 GO:0038179 neurotrophin signaling pathway 5/803 36/18722 0.0179476037420396 0.0875616540731842 NDN/SPRY1/SORT1/SOS1/KIDINS220 5 GO:0001779 natural killer cell differentiation 4/803 24/18722 0.0180005405986791 0.0875616540731842 GAS6/AXL/SP3/HECTD1 4 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 4/803 24/18722 0.0180005405986791 0.0875616540731842 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0002726 positive regulation of T cell cytokine production 4/803 24/18722 0.0180005405986791 0.0875616540731842 IL1R1/HLA-A/CD81/B2M 4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 4/803 24/18722 0.0180005405986791 0.0875616540731842 CREB3L1/THBS1/SPRY1/SULF2 4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 4/803 24/18722 0.0180005405986791 0.0875616540731842 IGFBP3/BMP5/IGFBP2/IGFBP5 4 GO:0048011 neurotrophin TRK receptor signaling pathway 4/803 24/18722 0.0180005405986791 0.0875616540731842 NDN/SPRY1/SORT1/SOS1 4 GO:0051043 regulation of membrane protein ectodomain proteolysis 4/803 24/18722 0.0180005405986791 0.0875616540731842 APOE/TIMP1/TIMP3/TIMP2 4 GO:0060479 lung cell differentiation 4/803 24/18722 0.0180005405986791 0.0875616540731842 GATA6/THRA/NFIB/YAP1 4 GO:0060571 morphogenesis of an epithelial fold 4/803 24/18722 0.0180005405986791 0.0875616540731842 BMP5/WNT2/BMP4/RDH10 4 GO:0061162 establishment of monopolar cell polarity 4/803 24/18722 0.0180005405986791 0.0875616540731842 MAP1B/FSCN1/PTK7/MSN 4 GO:2001026 regulation of endothelial cell chemotaxis 4/803 24/18722 0.0180005405986791 0.0875616540731842 SMOC2/THBS1/FGFR1/HSPB1 4 GO:0048511 rhythmic process 21/803 298/18722 0.0181440591876259 0.0881737613153046 PTGDS/PDGFRA/SLIT2/SLIT3/ADAMTS1/SERPINF1/PTEN/MDK/NCOR2/AXL/ROCK2/TWIST1/KMT2A/SETX/FOXO3/PRKAA1/ZFHX3/CLOCK/USP9X/HEBP1/NCOA1 21 GO:0033273 response to vitamin 9/803 93/18722 0.0182433406131877 0.0884837512620175 COL1A1/STC1/MAP1B/SNAI2/GATA4/GAS6/SPARC/KANK2/TSPO 9 GO:0045185 maintenance of protein location 9/803 93/18722 0.0182433406131877 0.0884837512620175 GJA1/FLNA/PKD1/PKD2/TSPO/FBN1/SYNE1/CCDC88A/GSN 9 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 8/803 78/18722 0.0184411470641961 0.0892694750117296 HGF/GAS6/THBS1/CRYAB/KLF4/PLAUR/SERPINB9/USP47 8 GO:0043297 apical junction assembly 8/803 78/18722 0.0184411470641961 0.0892694750117296 SNAI2/GJA1/CLDN1/MTDH/ROCK2/VCL/MYO1C/TJP1 8 GO:0070663 regulation of leukocyte proliferation 18/803 245/18722 0.0188448670915671 0.0911353126271129 IGFBP2/VCAM1/CSF1/KITLG/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/BST2/PRKAR1A/SOS1/ATM/NDFIP1 18 GO:2000045 regulation of G1/S transition of mitotic cell cycle 12/803 142/18722 0.0192509990622733 0.0930091873299365 CCND2/FHL1/KANK2/ADAMTS1/PTEN/GPNMB/PKD1/PKD2/PLCB1/KLF4/KMT2E/ATM 12 GO:0030098 lymphocyte differentiation 25/803 374/18722 0.0193503001217381 0.0933943179466803 VCAM1/GAS6/BMP4/TMEM98/LGALS1/MDK/AXL/B2M/PTPRK/PIK3R1/TGFBR2/ZFP36L2/ZFP36L1/ITGB1/NOTCH2/ABL1/STAT3/KLF6/ZMIZ1/SP3/HECTD1/PKNOX1/SOS1/ATM/NDFIP1 25 GO:0080164 regulation of nitric oxide metabolic process 7/803 64/18722 0.019384571264083 0.0933943179466803 CD36/CLU/PKD2/TSPO/ROCK2/KLF4/DDAH2 7 GO:0001935 endothelial cell proliferation 15/803 193/18722 0.0193869071549968 0.0933943179466803 F3/WNT2/ECM1/BMP4/SPARC/THBS1/APOE/FGFR1/GJA1/PRKCA/IGF2/MDK/NRP2/BMPR2/STAT3 15 GO:0030316 osteoclast differentiation 9/803 94/18722 0.0194353714768976 0.0935374152353392 CSF1/GPC3/CD81/SH3PXD2A/PIK3R1/NOTCH2/FBN1/GPR137B/GLO1 9 GO:1902930 regulation of alcohol biosynthetic process 6/803 50/18722 0.0194933996602012 0.0936359255354174 BMP5/DKK3/APOE/H6PD/PRKAA1/MBTPS1 6 GO:1904036 negative regulation of epithelial cell apoptotic process 6/803 50/18722 0.0194933996602012 0.0936359255354174 GAS6/ANGPT1/MDK/YAP1/NUPR1/ABL1 6 GO:2001233 regulation of apoptotic signaling pathway 24/803 356/18722 0.0197494083683178 0.0947142130462999 HGF/BMP5/SRPX/CREB3L1/SNAI2/GATA4/BMP4/THBS1/FGFR1/PTEN/TIMP3/CLU/YAP1/NUPR1/SERINC3/PLAUR/SGMS1/SKIL/ZMYND11/GCLM/RB1CC1/LTBR/HSPB1/USP47 24 GO:0002698 negative regulation of immune effector process 10/803 110/18722 0.0197748687888484 0.0947142130462999 ANGPT1/HLA-B/SERPING1/HLA-A/A2M/BST2/HLA-F/FER/SERPINB9/NDFIP1 10 GO:0003014 renal system process 10/803 110/18722 0.0197748687888484 0.0947142130462999 STC1/SPX/GAS6/BMP4/EDNRB/KCNMA1/GJA1/MYO1E/SULF2/GSN 10 GO:0002369 T cell cytokine production 5/803 37/18722 0.0200405108555025 0.0947180152815171 IL1R1/HLA-A/CD81/B2M/HLA-F 5 GO:0002724 regulation of T cell cytokine production 5/803 37/18722 0.0200405108555025 0.0947180152815171 IL1R1/HLA-A/CD81/B2M/HLA-F 5 GO:0032570 response to progesterone 5/803 37/18722 0.0200405108555025 0.0947180152815171 THBS1/TSPO/YAP1/TXNIP/NCOA1 5 GO:1900077 negative regulation of cellular response to insulin stimulus 5/803 37/18722 0.0200405108555025 0.0947180152815171 ENPP1/IRS1/SOCS3/PID1/PRKAA1 5 GO:1902745 positive regulation of lamellipodium organization 5/803 37/18722 0.0200405108555025 0.0947180152815171 ENPP2/FSCN1/PIK3R1/ABI2/NCKAP1 5 GO:0010838 positive regulation of keratinocyte proliferation 3/803 14/18722 0.0200796113422711 0.0947180152815171 FGF7/MDK/NOTCH2 3 GO:0010839 negative regulation of keratinocyte proliferation 3/803 14/18722 0.0200796113422711 0.0947180152815171 SNAI2/CASK/PTPRK 3 GO:0034111 negative regulation of homotypic cell-cell adhesion 3/803 14/18722 0.0200796113422711 0.0947180152815171 PRKG1/SERPINE2/CD9 3 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 3/803 14/18722 0.0200796113422711 0.0947180152815171 PDGFRB/LRP1/ABL1 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/803 14/18722 0.0200796113422711 0.0947180152815171 SPRED1/PLA2R1/ATM 3 GO:0051547 regulation of keratinocyte migration 3/803 14/18722 0.0200796113422711 0.0947180152815171 FGF7/PTEN/MAP4K4 3 GO:0060841 venous blood vessel development 3/803 14/18722 0.0200796113422711 0.0947180152815171 HEG1/ENG/BMPR2 3 GO:0070278 extracellular matrix constituent secretion 3/803 14/18722 0.0200796113422711 0.0947180152815171 CREB3L1/ENG/TNFRSF1A 3 GO:0070307 lens fiber cell development 3/803 14/18722 0.0200796113422711 0.0947180152815171 VIM/ABI2/FRS2 3 GO:0070986 left/right axis specification 3/803 14/18722 0.0200796113422711 0.0947180152815171 PITX2/NOTCH2/EPB41L5 3 GO:0071481 cellular response to X-ray 3/803 14/18722 0.0200796113422711 0.0947180152815171 CCND2/ATM/NUCKS1 3 GO:0071496 cellular response to external stimulus 22/803 320/18722 0.0204336823418535 0.0962971078983758 COL1A1/VCAM1/SNAI2/GAS6/KANK2/GJA1/PIEZO1/PDK4/AXL/SESN3/ENG/TNFRSF1A/BMPR2/CNN2/PLEC/SLC38A2/SLC39A4/FOXO3/PRKAA1/IFI16/LTBR/NCOA1 22 GO:0006469 negative regulation of protein kinase activity 16/803 212/18722 0.0206527254763221 0.0963710195284105 THY1/BMP4/APOE/CAMK2N1/HEG1/SPRY1/PTEN/LRP6/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/HIPK3/SLC8A1/HSPB1 16 GO:0008585 female gonad development 9/803 95/18722 0.0206827533699966 0.0963710195284105 PDGFRA/SLIT2/FST/SLIT3/KITLG/ADAMTS1/NUPR1/ARID5B/FOXO3 9 GO:1901379 regulation of potassium ion transmembrane transport 9/803 95/18722 0.0206827533699966 0.0963710195284105 FHL1/BIN1/FLNA/ATP1B1/PTEN/CD63/PRNP/ITGB1/WNK1 9 GO:0003094 glomerular filtration 4/803 25/18722 0.0207199624818404 0.0963710195284105 GAS6/GJA1/MYO1E/SULF2 4 GO:0030318 melanocyte differentiation 4/803 25/18722 0.0207199624818404 0.0963710195284105 ENPP1/KITLG/EDNRB/ZEB2 4 GO:0051291 protein heterooligomerization 4/803 25/18722 0.0207199624818404 0.0963710195284105 COL1A2/PKD1/PKD2/TMEM120A 4 GO:0051450 myoblast proliferation 4/803 25/18722 0.0207199624818404 0.0963710195284105 HGF/GATA6/MEIS2/MALAT1 4 GO:0060074 synapse maturation 4/803 25/18722 0.0207199624818404 0.0963710195284105 PALM/NFIA/PTEN/CLSTN1 4 GO:0061339 establishment or maintenance of monopolar cell polarity 4/803 25/18722 0.0207199624818404 0.0963710195284105 MAP1B/FSCN1/PTK7/MSN 4 GO:0072202 cell differentiation involved in metanephros development 4/803 25/18722 0.0207199624818404 0.0963710195284105 TCF21/BMP4/LAMB2/YAP1 4 GO:0072207 metanephric epithelium development 4/803 25/18722 0.0207199624818404 0.0963710195284105 LAMB2/PKD1/PKD2/YAP1 4 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 4/803 25/18722 0.0207199624818404 0.0963710195284105 GJA1/ATP1B1/CAMK2D/SLC8A1 4 GO:1900078 positive regulation of cellular response to insulin stimulus 4/803 25/18722 0.0207199624818404 0.0963710195284105 IGF2/IRS1/MYO1C/NUCKS1 4 GO:1905564 positive regulation of vascular endothelial cell proliferation 4/803 25/18722 0.0207199624818404 0.0963710195284105 FGFR1/IGF2/MDK/STAT3 4 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 10/803 111/18722 0.0209294271894313 0.0972495017072884 DCN/HGF/PDGFRA/PDGFRB/SERPINE2/FGFR1/ANGPT1/PTEN/TWIST1/KLF4 10 GO:0002720 positive regulation of cytokine production involved in immune response 7/803 65/18722 0.0209478469381524 0.0972495017072884 SPON2/CD36/IL1R1/HLA-A/CD81/B2M/HLA-F 7 GO:0010874 regulation of cholesterol efflux 6/803 51/18722 0.0213172447798569 0.0986887488137106 ABCA8/APOE/CES1/LRP1/PLTP/ABCA5 6 GO:0045104 intermediate filament cytoskeleton organization 6/803 51/18722 0.0213172447798569 0.0986887488137106 DES/PPL/VIM/DST/PLEC/MACF1 6 GO:0050982 detection of mechanical stimulus 6/803 51/18722 0.0213172447798569 0.0986887488137106 COL11A1/SERPINE2/PIEZO1/PKD1/PKD2/TMEM120A 6 GO:0043583 ear development 16/803 213/18722 0.0214775795928968 0.0993387865029533 CTHRC1/CYTL1/COL11A1/PDGFRB/HOXA13/BMP4/SPARC/MAF/OSR2/ECE1/TSHZ1/RDH10/PTK7/TWIST1/JAG1/CEP290 16 GO:0002718 regulation of cytokine production involved in immune response 9/803 96/18722 0.0219867764655434 0.101505618015925 SPON2/CD36/IL1R1/ANGPT1/HLA-A/CD81/B2M/BST2/HLA-F 9 GO:0035282 segmentation 9/803 96/18722 0.0219867764655434 0.101505618015925 BMP4/MLLT3/BASP1/NRP2/LRP6/PCSK6/FRS2/EPB41L5/MIB1 9 GO:0010613 positive regulation of cardiac muscle hypertrophy 5/803 38/18722 0.0222868852652543 0.102511448277267 HAND2/PRKCA/IL6ST/CAMK2D/ROCK2 5 GO:0042596 fear response 5/803 38/18722 0.0222868852652543 0.102511448277267 APOE/GJA1/EXT1/MDK/DPP4 5 GO:0097242 amyloid-beta clearance 5/803 38/18722 0.0222868852652543 0.102511448277267 CD36/APOE/LRP1/CLU/CLTC 5 GO:1901031 regulation of response to reactive oxygen species 5/803 38/18722 0.0222868852652543 0.102511448277267 HGF/FBLN5/CD36/SESN3/FOXO3 5 GO:0000082 G1/S transition of mitotic cell cycle 16/803 214/18722 0.0223271929590641 0.102602197321561 CCND2/FHL1/KANK2/ADAMTS1/PTEN/CDK18/GPNMB/PKD1/PKD2/EIF4EBP1/PLCB1/ITGB1/KLF4/BACH1/KMT2E/ATM 16 GO:0051494 negative regulation of cytoskeleton organization 13/803 162/18722 0.0224034471036335 0.102857815155356 SLIT2/MAP1B/PLEKHH2/LMOD1/MYADM/SPTBN1/PIK3R1/EPS8/DLC1/ARHGAP28/TAOK1/GSN/TJP1 13 GO:0051348 negative regulation of transferase activity 19/803 268/18722 0.0225067116902347 0.103236857854195 THY1/BMP4/APOE/CAMK2N1/HEG1/SPRY1/PTEN/LRP6/SPRED1/PRKAR1A/ABL1/PKIG/EIF4A2/PLEC/HIPK3/WNK1/SLC8A1/TERF1/HSPB1 19 GO:0050918 positive chemotaxis 7/803 66/18722 0.0225966199646312 0.103553995536444 HGF/FGF7/F3/BMP4/ANGPT1/GPNMB/LRP1 7 GO:0001942 hair follicle development 8/803 81/18722 0.0226466615067905 0.103592893828309 FGF7/IGFBP5/FST/LDB2/EXT1/APCDD1/ZDHHC21/SOS1 8 GO:0046209 nitric oxide metabolic process 8/803 81/18722 0.0226466615067905 0.103592893828309 CD36/CLU/PKD2/TSPO/ROCK2/KLF4/CYB5R3/DDAH2 8 GO:0010721 negative regulation of cell development 14/803 180/18722 0.0232309453221282 0.10588086546292 THY1/EDNRB/TMEM98/SEMA3B/PTEN/B2M/TSPO/FBN1/SEMA6D/FBLN1/RTN4/SKI/CERS2/ACTN4 14 GO:0043409 negative regulation of MAPK cascade 14/803 180/18722 0.0232309453221282 0.10588086546292 EMILIN1/BMP4/APOE/CAMK2N1/SPRY1/PTEN/TIMP3/SPRED1/KLF4/ABL1/ASH1L/HIPK3/FBLN1/ZMYND11 14 GO:0045103 intermediate filament-based process 6/803 52/18722 0.0232530179867424 0.10588086546292 DES/PPL/VIM/DST/PLEC/MACF1 6 GO:0051496 positive regulation of stress fiber assembly 6/803 52/18722 0.0232530179867424 0.10588086546292 LPAR1/ROCK2/SORBS3/ABL1/TPM1/CCDC88A 6 GO:0060147 regulation of posttranscriptional gene silencing 6/803 52/18722 0.0232530179867424 0.10588086546292 MAEL/BMP4/KCNQ1OT1/NCOR2/STAT3/PUM2 6 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 9/803 97/18722 0.0233487049432211 0.106219564641333 HGF/BMP5/SNAI2/BMP4/THBS1/YAP1/ZMYND11/GCLM/RB1CC1 9 GO:0031623 receptor internalization 10/803 113/18722 0.0233845899268916 0.106285838993146 CD36/ANGPT1/RAMP1/CD9/CD81/CD63/LRP1/ITGB1/AP2B1/CLTC 10 GO:0014829 vascular associated smooth muscle contraction 4/803 26/18722 0.0236781553898434 0.106937756135651 EDNRB/ACTA2/SLC8A1/ZDHHC21 4 GO:0021952 central nervous system projection neuron axonogenesis 4/803 26/18722 0.0236781553898434 0.106937756135651 CDH11/SLIT2/NFIB/NIN 4 GO:0034114 regulation of heterotypic cell-cell adhesion 4/803 26/18722 0.0236781553898434 0.106937756135651 THY1/MYADM/KLF4/WNK1 4 GO:0060037 pharyngeal system development 4/803 26/18722 0.0236781553898434 0.106937756135651 BMP5/BMP4/ECE1/BMPR2 4 GO:0072273 metanephric nephron morphogenesis 4/803 26/18722 0.0236781553898434 0.106937756135651 PDGFRB/BMP4/PKD1/PKD2 4 GO:0097205 renal filtration 4/803 26/18722 0.0236781553898434 0.106937756135651 GAS6/GJA1/MYO1E/SULF2 4 GO:1904861 excitatory synapse assembly 4/803 26/18722 0.0236781553898434 0.106937756135651 PTPRD/PTEN/PLXNB2/NPTN 4 GO:2001057 reactive nitrogen species metabolic process 8/803 82/18722 0.0241872872320599 0.108035417451431 CD36/CLU/PKD2/TSPO/ROCK2/KLF4/CYB5R3/DDAH2 8 GO:0032640 tumor necrosis factor production 14/803 181/18722 0.0242259671374417 0.108035417451431 SPON2/GAS6/CD36/AKAP12/THBS1/ANGPT1/GPNMB/AXL/CLU/PIK3R1/TSPO/TWIST1/STAT3/HSPB1 14 GO:0032680 regulation of tumor necrosis factor production 14/803 181/18722 0.0242259671374417 0.108035417451431 SPON2/GAS6/CD36/AKAP12/THBS1/ANGPT1/GPNMB/AXL/CLU/PIK3R1/TSPO/TWIST1/STAT3/HSPB1 14 GO:0006704 glucocorticoid biosynthetic process 3/803 15/18722 0.0243148881859526 0.108035417451431 BMP5/DKK3/H6PD 3 GO:0019511 peptidyl-proline hydroxylation 3/803 15/18722 0.0243148881859526 0.108035417451431 P4HA2/EGLN3/CRTAP 3 GO:0032486 Rap protein signal transduction 3/803 15/18722 0.0243148881859526 0.108035417451431 RAP2A/RAP2B/TIMP2 3 GO:0036376 sodium ion export across plasma membrane 3/803 15/18722 0.0243148881859526 0.108035417451431 FXYD1/ATP1B1/SLC8A1 3 GO:0060253 negative regulation of glial cell proliferation 3/803 15/18722 0.0243148881859526 0.108035417451431 TSPO/SKI/CERS2 3 GO:0060413 atrial septum morphogenesis 3/803 15/18722 0.0243148881859526 0.108035417451431 GATA4/NOTCH2/BMPR2 3 GO:0070831 basement membrane assembly 3/803 15/18722 0.0243148881859526 0.108035417451431 PHLDB1/LAMB2/LAMB1 3 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/803 15/18722 0.0243148881859526 0.108035417451431 TNRC6C/ZFP36L2/ZFP36L1 3 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 3/803 15/18722 0.0243148881859526 0.108035417451431 BIN1/CAMK2D/SESTD1 3 GO:1903729 regulation of plasma membrane organization 3/803 15/18722 0.0243148881859526 0.108035417451431 ASAP1/WASL/GSN 3 GO:1905146 lysosomal protein catabolic process 3/803 15/18722 0.0243148881859526 0.108035417451431 LAPTM4B/TMEM106B/LRP1 3 GO:2001028 positive regulation of endothelial cell chemotaxis 3/803 15/18722 0.0243148881859526 0.108035417451431 SMOC2/FGFR1/HSPB1 3 GO:0009880 embryonic pattern specification 7/803 67/18722 0.0243328868427511 0.108035417451431 MEIS2/BASP1/SMAD5/NRP2/PCSK6/FRS2/EPB41L5 7 GO:0010517 regulation of phospholipase activity 7/803 67/18722 0.0243328868427511 0.108035417451431 PDGFRA/PDGFRB/LPAR1/FGFR1/LRP1/ABL1/PLA2R1 7 GO:0050435 amyloid-beta metabolic process 7/803 67/18722 0.0243328868427511 0.108035417451431 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:0072665 protein localization to vacuole 7/803 67/18722 0.0243328868427511 0.108035417451431 CD81/CLU/ROCK2/SCARB2/GPR137B/RTN4/SORT1 7 GO:0002244 hematopoietic progenitor cell differentiation 10/803 114/18722 0.0246872444003151 0.108750774196828 PDGFRA/FST/KITLG/BMP4/MLLT3/EXT1/ABL1/N4BP2L2/SBDS/SOS1 10 GO:0046660 female sex differentiation 10/803 114/18722 0.0246872444003151 0.108750774196828 PDGFRA/SLIT2/FST/SLIT3/KITLG/ADAMTS1/AXL/NUPR1/ARID5B/FOXO3 10 GO:0002347 response to tumor cell 5/803 39/18722 0.0246903081409565 0.108750774196828 HLA-A/RBMS3/TXNIP/KLF4/DAPK1 5 GO:0014742 positive regulation of muscle hypertrophy 5/803 39/18722 0.0246903081409565 0.108750774196828 HAND2/PRKCA/IL6ST/CAMK2D/ROCK2 5 GO:0071548 response to dexamethasone 5/803 39/18722 0.0246903081409565 0.108750774196828 FIBIN/CLDN1/SERPINF1/NR3C1/FOXO3 5 GO:1901861 regulation of muscle tissue development 5/803 39/18722 0.0246903081409565 0.108750774196828 IGFBP5/BMP4/IGF2/TWIST1/PRKAA1 5 GO:1902742 apoptotic process involved in development 5/803 39/18722 0.0246903081409565 0.108750774196828 SLIT2/HAND2/SLIT3/CRYAB/TNFRSF1A 5 GO:1903115 regulation of actin filament-based movement 5/803 39/18722 0.0246903081409565 0.108750774196828 PDPN/STC1/GATA4/BIN1/CAMK2D 5 GO:2000249 regulation of actin cytoskeleton reorganization 5/803 39/18722 0.0246903081409565 0.108750774196828 PDGFRA/MDK/NOTCH2/ABL1/TJP1 5 GO:0002367 cytokine production involved in immune response 9/803 98/18722 0.0247697748646394 0.109004499095403 SPON2/CD36/IL1R1/ANGPT1/HLA-A/CD81/B2M/BST2/HLA-F 9 GO:0060966 regulation of gene silencing by RNA 6/803 53/18722 0.0253032976199993 0.111156160293671 MAEL/BMP4/KCNQ1OT1/NCOR2/STAT3/PUM2 6 GO:1990090 cellular response to nerve growth factor stimulus 6/803 53/18722 0.0253032976199993 0.111156160293671 PTEN/ACAP2/FOXO3/SORT1/KIDINS220/BPTF 6 GO:0019079 viral genome replication 11/803 131/18722 0.0254047586626623 0.111405564372941 GAS6/NFIA/IFITM2/IFITM3/IFITM1/ROCK2/BST2/STOM/FAM111A/IFI16/NUCKS1 11 GO:0046683 response to organophosphorus 11/803 131/18722 0.0254047586626623 0.111405564372941 COL1A1/STC1/IGFBP5/PDE3A/SPARC/PTEN/PKD2/ZFP36L1/SDC1/HSP90B1/SLC8A1 11 GO:0014074 response to purine-containing compound 12/803 148/18722 0.0256626693481524 0.112240411727972 COL1A1/STC1/IGFBP5/PDE3A/SPARC/PTEN/PKD2/ZFP36L1/SDC1/HSP90B1/PRKAA1/SLC8A1 12 GO:0044272 sulfur compound biosynthetic process 12/803 148/18722 0.0256626693481524 0.112240411727972 ELOVL2/PAPSS2/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/PDK4/EXT1/UGDH/CHPF2/GCLM/PAPSS1 12 GO:0070507 regulation of microtubule cytoskeleton organization 12/803 148/18722 0.0256626693481524 0.112240411727972 MAP1B/EPHA3/PHLDB1/PKD1/GNAI1/MPDZ/NIN/ABL1/MAP9/TAOK1/PRKAA1/CLTC 12 GO:0042987 amyloid precursor protein catabolic process 7/803 68/18722 0.0261585612690816 0.114208919866586 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:1904888 cranial skeletal system development 7/803 68/18722 0.0261585612690816 0.114208919866586 PDGFRA/BMP4/RDH10/RAB23/EXT1/TWIST1/TGFBR2 7 GO:0032943 mononuclear cell proliferation 20/803 291/18722 0.0262553310626749 0.114531129202535 IGFBP2/VCAM1/CSF1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/CD151/PRKAR1A/ABL1/PURA/MSN/SOS1/ATM/NDFIP1 20 GO:0010639 negative regulation of organelle organization 23/803 347/18722 0.0262972900217581 0.114613888154271 HGF/SLIT2/MAP1B/PLEKHH2/LMOD1/BMP4/MYADM/SPTBN1/CLU/PIK3R1/TSPO/YAP1/NUPR1/EPS8/DLC1/PRKAR1A/ARHGAP28/TAOK1/ATRX/GSN/TJP1/TERF1/ATM 23 GO:0007611 learning or memory 18/803 255/18722 0.0268540300805601 0.116938160682684 CCND2/ADCY3/APOE/THRA/MEIS2/SERPINF1/PTEN/MDK/B2M/PRNP/PLCB1/ITGB1/NPTN/AMFR/EIF4EBP2/VLDLR/PJA2/ATXN1 18 GO:0010894 negative regulation of steroid biosynthetic process 4/803 27/18722 0.0268792870905043 0.116946008231461 BMP5/DKK3/SNAI2/APOE 4 GO:0033673 negative regulation of kinase activity 17/803 237/18722 0.0269834124514041 0.11729668219939 THY1/BMP4/APOE/CAMK2N1/HEG1/SPRY1/PTEN/LRP6/SPRED1/PRKAR1A/ABL1/PKIG/PLEC/HIPK3/WNK1/SLC8A1/HSPB1 17 GO:0014037 Schwann cell differentiation 5/803 40/18722 0.0272540192414152 0.118061285784271 LAMA2/LAMB2/NDRG1/PLEC/SKI 5 GO:0030501 positive regulation of bone mineralization 5/803 40/18722 0.0272540192414152 0.118061285784271 BMP4/OSR2/ACVR2A/BMPR2/SLC8A1 5 GO:0045429 positive regulation of nitric oxide biosynthetic process 5/803 40/18722 0.0272540192414152 0.118061285784271 CD36/CLU/PKD2/KLF4/DDAH2 5 GO:0045777 positive regulation of blood pressure 5/803 40/18722 0.0272540192414152 0.118061285784271 RARRES2/SPX/CAMK2N1/TPM1/WNK1 5 GO:0030834 regulation of actin filament depolymerization 6/803 54/18722 0.0274705018010559 0.118448105283487 PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/GSN 6 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 6/803 54/18722 0.0274705018010559 0.118448105283487 BMP4/NFIB/NR3C1/KLF4/FOXO3/STAT3 6 GO:0006970 response to osmotic stress 8/803 84/18722 0.0274858519480535 0.118448105283487 MYLK/KCNMA1/CLDN1/PKD2/TSPO/NFAT5/ZFP36L1/TSC22D4 8 GO:0010660 regulation of muscle cell apoptotic process 8/803 84/18722 0.0274858519480535 0.118448105283487 HAND2/GATA4/PTEN/CAMK2D/MDK/LRP6/NUPR1/CAPN2 8 GO:0022404 molting cycle process 8/803 84/18722 0.0274858519480535 0.118448105283487 FGF7/IGFBP5/FST/LDB2/EXT1/APCDD1/ZDHHC21/SOS1 8 GO:0022405 hair cycle process 8/803 84/18722 0.0274858519480535 0.118448105283487 FGF7/IGFBP5/FST/LDB2/EXT1/APCDD1/ZDHHC21/SOS1 8 GO:0019218 regulation of steroid metabolic process 9/803 100/18722 0.0277941303240809 0.119569916993846 BMP5/DKK3/SNAI2/APOE/CES1/TSPO/H6PD/PRKAA1/MBTPS1 9 GO:0046545 development of primary female sexual characteristics 9/803 100/18722 0.0277941303240809 0.119569916993846 PDGFRA/SLIT2/FST/SLIT3/KITLG/ADAMTS1/NUPR1/ARID5B/FOXO3 9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 13/803 167/18722 0.027877545706608 0.119825381804437 CDH11/CADM3/PCDH10/PCDH18/AMIGO2/NEXN/PALLD/ROBO1/PKD1/ITGB1/PLXNB2/NPTN/CLSTN1 13 GO:0046328 regulation of JNK cascade 11/803 133/18722 0.0280104128703056 0.120292780853871 MFHAS1/PLCB1/RAP2A/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/PJA2/RB1CC1/LTBR 11 GO:0010611 regulation of cardiac muscle hypertrophy 7/803 69/18722 0.0280754698501071 0.12036482602978 HAND2/PRKCA/IL6ST/CAMK2D/LMCD1/ROCK2/TNFRSF1A 7 GO:0033344 cholesterol efflux 7/803 69/18722 0.0280754698501071 0.12036482602978 ABCA8/APOE/CES1/LRP1/PLTP/NPC2/ABCA5 7 GO:0051604 protein maturation 20/803 294/18722 0.02884778714673 0.12261060705003 F3/C1R/SPON1/CPXM1/ADAMTS2/SERPINE2/THBS1/TMEM98/GAS1/ECE1/PLAU/TSPAN5/SERPINH1/PRNP/PCSK6/CAPN2/FAM111A/TMEM59/IFI16/GSN 20 GO:0002693 positive regulation of cellular extravasation 3/803 16/18722 0.028992760872841 0.12261060705003 THY1/IL1R1/MDK 3 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 3/803 16/18722 0.028992760872841 0.12261060705003 SNAI2/TGFBR2/ENG 3 GO:0009299 mRNA transcription 3/803 16/18722 0.028992760872841 0.12261060705003 FLNA/HIPK3/STAT3 3 GO:0009415 response to water 3/803 16/18722 0.028992760872841 0.12261060705003 CD9/PKD2/PLEC 3 GO:0010649 regulation of cell communication by electrical coupling 3/803 16/18722 0.028992760872841 0.12261060705003 GJA1/CAMK2D/SLC8A1 3 GO:0034375 high-density lipoprotein particle remodeling 3/803 16/18722 0.028992760872841 0.12261060705003 APOE/PLTP/ABCA5 3 GO:0042481 regulation of odontogenesis 3/803 16/18722 0.028992760872841 0.12261060705003 CSF1/RSPO2/BMP4 3 GO:0044849 estrous cycle 3/803 16/18722 0.028992760872841 0.12261060705003 MDK/NCOR2/NCOA1 3 GO:0060572 morphogenesis of an epithelial bud 3/803 16/18722 0.028992760872841 0.12261060705003 WNT2/BMP4/RDH10 3 GO:0061684 chaperone-mediated autophagy 3/803 16/18722 0.028992760872841 0.12261060705003 SYNPO2/CLU/CTSA 3 GO:0072109 glomerular mesangium development 3/803 16/18722 0.028992760872841 0.12261060705003 PDGFRB/BMP4/ACTA2 3 GO:1901201 regulation of extracellular matrix assembly 3/803 16/18722 0.028992760872841 0.12261060705003 ANTXR1/EMILIN1/PHLDB1 3 GO:1902931 negative regulation of alcohol biosynthetic process 3/803 16/18722 0.028992760872841 0.12261060705003 BMP5/DKK3/APOE 3 GO:1905906 regulation of amyloid fibril formation 3/803 16/18722 0.028992760872841 0.12261060705003 CRYAB/APOE/CLU 3 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 3/803 16/18722 0.028992760872841 0.12261060705003 ATP1B1/WNK1/ACTN4 3 GO:0032103 positive regulation of response to external stimulus 27/803 427/18722 0.0291052187043646 0.122981881745731 RARRES2/F3/PLA2G2A/SLIT2/CSF1/PDGFRB/SMOC2/GAS6/THBS1/OSMR/FGFR1/PRKCA/CMKLR1/IL6ST/FLNA/CD81/MDK/LRP1/NUPR1/TNFRSF1A/BMPR2/HLA-F/WNK1/IFI16/PUM2/HSPB1/CLOCK 27 GO:0045787 positive regulation of cell cycle 21/803 313/18722 0.0291687115868778 0.123145805226226 CCND2/PDGFRB/SMOC2/HOXA13/PRKCA/ADAMTS1/IGF2/HSPA2/MEIS2/PKD1/PKD2/EIF4EBP1/ROCK2/DYNLT3/LRP6/PLCB1/NUPR1/CDC25B/ABL1/ATRX/KMT2E 21 GO:0055072 iron ion homeostasis 8/803 85/18722 0.0292466583719857 0.123370421863554 CYBRD1/BDH2/STEAP4/EPAS1/B2M/SLC40A1/FRRS1/NDFIP1 8 GO:0006476 protein deacetylation 9/803 101/18722 0.0293997290446304 0.123911284037639 NDN/NNMT/FLNA/CAMK2D/SPRED1/TBL1XR1/SKI/PRKAA1/MIER1 9 GO:0071706 tumor necrosis factor superfamily cytokine production 14/803 186/18722 0.0296823766675972 0.124841138001306 SPON2/GAS6/CD36/AKAP12/THBS1/ANGPT1/GPNMB/AXL/CLU/PIK3R1/TSPO/TWIST1/STAT3/HSPB1 14 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 14/803 186/18722 0.0296823766675972 0.124841138001306 SPON2/GAS6/CD36/AKAP12/THBS1/ANGPT1/GPNMB/AXL/CLU/PIK3R1/TSPO/TWIST1/STAT3/HSPB1 14 GO:0042593 glucose homeostasis 18/803 258/18722 0.0296954652365721 0.124841138001306 IGFBP5/GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/IRS1/PDK4/LRP1/PIK3R1/SESN3/SIDT2/FOXO3/STAT3/PRKAA1/MAP4K4/GCLM/NUCKS1 18 GO:0002067 glandular epithelial cell differentiation 6/803 55/18722 0.029756882642288 0.124888734725966 BMP5/GATA6/BMP4/EXT1/SIDT2/CLOCK 6 GO:0061614 pri-miRNA transcription by RNA polymerase II 6/803 55/18722 0.029756882642288 0.124888734725966 BMP4/NFIB/NR3C1/KLF4/FOXO3/STAT3 6 GO:0055023 positive regulation of cardiac muscle tissue growth 5/803 41/18722 0.029980910801955 0.125617496855922 WNT2/TBX2/GATA6/TGFBR3/YAP1 5 GO:1904407 positive regulation of nitric oxide metabolic process 5/803 41/18722 0.029980910801955 0.125617496855922 CD36/CLU/PKD2/KLF4/DDAH2 5 GO:0070830 bicellular tight junction assembly 7/803 70/18722 0.030085348103373 0.125949240674574 SNAI2/GJA1/CLDN1/MTDH/ROCK2/MYO1C/TJP1 7 GO:0010464 regulation of mesenchymal cell proliferation 4/803 28/18722 0.0303266465197316 0.126640418381392 WNT2/BMP4/NFIB/TGFBR2 4 GO:0031342 negative regulation of cell killing 4/803 28/18722 0.0303266465197316 0.126640418381392 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0060765 regulation of androgen receptor signaling pathway 4/803 28/18722 0.0303266465197316 0.126640418381392 TCF21/PIAS2/NCOR2/DAB2 4 GO:0033500 carbohydrate homeostasis 18/803 259/18722 0.0306907672011982 0.128053694782572 IGFBP5/GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/IRS1/PDK4/LRP1/PIK3R1/SESN3/SIDT2/FOXO3/STAT3/PRKAA1/MAP4K4/GCLM/NUCKS1 18 GO:0030308 negative regulation of cell growth 14/803 188/18722 0.0320993070960648 0.133304423628492 MEG3/ENPP1/SLIT2/WFDC1/FHL1/SLIT3/SERPINE2/CRYAB/GJA1/SEMA3B/BST2/BMPR2/SEMA6D/RTN4 14 GO:0002711 positive regulation of T cell mediated immunity 6/803 56/18722 0.0321645211592482 0.133304423628492 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F 6 GO:0042733 embryonic digit morphogenesis 6/803 56/18722 0.0321645211592482 0.133304423628492 HAND2/TBX2/BMP4/OSR2/ECE1/TWIST1 6 GO:0045071 negative regulation of viral genome replication 6/803 56/18722 0.0321645211592482 0.133304423628492 IFITM2/IFITM3/IFITM1/BST2/FAM111A/IFI16 6 GO:0051058 negative regulation of small GTPase mediated signal transduction 6/803 56/18722 0.0321645211592482 0.133304423628492 SLIT2/HEG1/SPRY1/ITGB1/DLC1/TIMP2 6 GO:0055078 sodium ion homeostasis 6/803 56/18722 0.0321645211592482 0.133304423628492 C7/SPX/EDNRB/ATP1B1/EXT1/SLC8A1 6 GO:0071385 cellular response to glucocorticoid stimulus 6/803 56/18722 0.0321645211592482 0.133304423628492 STC1/SERPINF1/NR3C1/ZFP36L2/ZFP36L1/FOXO3 6 GO:1990089 response to nerve growth factor 6/803 56/18722 0.0321645211592482 0.133304423628492 PTEN/ACAP2/FOXO3/SORT1/KIDINS220/BPTF 6 GO:0045824 negative regulation of innate immune response 7/803 71/18722 0.0321898367526484 0.133304423628492 HLA-B/SERPING1/HLA-A/A2M/HLA-F/IFI16/SERPINB9 7 GO:0032760 positive regulation of tumor necrosis factor production 9/803 103/18722 0.0328032840078199 0.135014322171714 SPON2/CD36/AKAP12/THBS1/CLU/PIK3R1/TWIST1/STAT3/HSPB1 9 GO:0045639 positive regulation of myeloid cell differentiation 9/803 103/18722 0.0328032840078199 0.135014322171714 CSF1/KITLG/PRKCA/ACVR2A/ZFP36L1/NOTCH2/JAG1/FOXO3/STAT3 9 GO:0000413 protein peptidyl-prolyl isomerization 5/803 42/18722 0.0328735232885 0.135014322171714 FKBP7/FKBP10/PPIC/FKBP9/FKBP14 5 GO:0021795 cerebral cortex cell migration 5/803 42/18722 0.0328735232885 0.135014322171714 SLIT2/ROBO1/LAMB1/RTN4/ZMIZ1 5 GO:0045047 protein targeting to ER 5/803 42/18722 0.0328735232885 0.135014322171714 MAN1A1/TRAM1/SEC61A1/TRAM2/SEC62 5 GO:0045773 positive regulation of axon extension 5/803 42/18722 0.0328735232885 0.135014322171714 MAP1B/LRP1/BMPR2/MACF1/GOLGA4 5 GO:0046596 regulation of viral entry into host cell 5/803 42/18722 0.0328735232885 0.135014322171714 IFITM2/IFITM3/LGALS1/IFITM1/GSN 5 GO:0090317 negative regulation of intracellular protein transport 5/803 42/18722 0.0328735232885 0.135014322171714 APOD/CD36/ANGPT1/RAB23/PKIG 5 GO:1900274 regulation of phospholipase C activity 5/803 42/18722 0.0328735232885 0.135014322171714 PDGFRA/PDGFRB/LPAR1/FGFR1/ABL1 5 GO:2001222 regulation of neuron migration 5/803 42/18722 0.0328735232885 0.135014322171714 COL3A1/FLNA/MDK/PLXNB2/STAT3 5 GO:0150104 transport across blood-brain barrier 8/803 87/18722 0.032998072360046 0.135302951305254 SLC22A3/CD36/APOE/SLC2A10/SLC16A7/LRP1/SLC5A3/SLC38A2 8 GO:1901879 regulation of protein depolymerization 8/803 87/18722 0.032998072360046 0.135302951305254 MAP1B/PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/TAOK1/GSN 8 GO:0008037 cell recognition 16/803 225/18722 0.0334283489730069 0.136954599818745 NDN/SPON2/EPHA3/CD36/VCAN/MFGE8/NEXN/PALLD/CD9/CD81/NRCAM/EXT1/ROBO1/RTN4/NPTN/MSN 16 GO:0030856 regulation of epithelial cell differentiation 12/803 154/18722 0.0335102160769608 0.137177288472682 BMP4/PROM1/SPRY1/ROCK2/PLCB1/YAP1/ZFP36L1/TNFRSF1A/SPRED1/JAG1/VCL/ZDHHC21 12 GO:0060048 cardiac muscle contraction 11/803 137/18722 0.0337883460694383 0.137823151662893 STC1/GATA4/GJA1/BIN1/FLNA/ATP1B1/CAMK2D/SMAD5/TPM1/SLC8A1/GSN 11 GO:0001916 positive regulation of T cell mediated cytotoxicity 4/803 29/18722 0.0340226643128389 0.137823151662893 HLA-B/HLA-A/B2M/HLA-F 4 GO:0002068 glandular epithelial cell development 4/803 29/18722 0.0340226643128389 0.137823151662893 BMP5/BMP4/SIDT2/CLOCK 4 GO:0010592 positive regulation of lamellipodium assembly 4/803 29/18722 0.0340226643128389 0.137823151662893 FSCN1/PIK3R1/ABI2/NCKAP1 4 GO:0021772 olfactory bulb development 4/803 29/18722 0.0340226643128389 0.137823151662893 SLIT2/EXT1/ROBO1/SKI 4 GO:0031069 hair follicle morphogenesis 4/803 29/18722 0.0340226643128389 0.137823151662893 FGF7/IGFBP5/FST/EXT1 4 GO:0048265 response to pain 4/803 29/18722 0.0340226643128389 0.137823151662893 THBS1/EDNRB/TSPO/CAPN2 4 GO:0007351 tripartite regional subdivision 3/803 17/18722 0.0341102625655857 0.137823151662893 BASP1/PCSK6/FRS2 3 GO:0008595 anterior/posterior axis specification, embryo 3/803 17/18722 0.0341102625655857 0.137823151662893 BASP1/PCSK6/FRS2 3 GO:0010566 regulation of ketone biosynthetic process 3/803 17/18722 0.0341102625655857 0.137823151662893 BMP5/DKK3/H6PD 3 GO:0034349 glial cell apoptotic process 3/803 17/18722 0.0341102625655857 0.137823151662893 GAS6/AKAP12/PRKCA 3 GO:0044539 long-chain fatty acid import into cell 3/803 17/18722 0.0341102625655857 0.137823151662893 SPX/CD36/THBS1 3 GO:0055003 cardiac myofibril assembly 3/803 17/18722 0.0341102625655857 0.137823151662893 PDGFRA/PDGFRB/NEBL 3 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 3/803 17/18722 0.0341102625655857 0.137823151662893 BIN1/CAMK2D/SESTD1 3 GO:0140354 lipid import into cell 3/803 17/18722 0.0341102625655857 0.137823151662893 SPX/CD36/THBS1 3 GO:2000811 negative regulation of anoikis 3/803 17/18722 0.0341102625655857 0.137823151662893 SNAI2/PDK4/ITGB1 3 GO:0001678 cellular glucose homeostasis 13/803 172/18722 0.0342707698181191 0.138359561387159 GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/LRP1/PIK3R1/SIDT2/FOXO3/PRKAA1/MAP4K4/GCLM/NUCKS1 13 GO:0000271 polysaccharide biosynthetic process 7/803 72/18722 0.0343904783211595 0.138394612517596 ENPP1/CSGALNACT1/CSGALNACT2/IGF2/IRS1/EXT1/CLTC 7 GO:0042246 tissue regeneration 7/803 72/18722 0.0343904783211595 0.138394612517596 APOD/GATA4/CD9/CD81/MDK/TGFBR2/YAP1 7 GO:0071479 cellular response to ionizing radiation 7/803 72/18722 0.0343904783211595 0.138394612517596 CCND2/CRYAB/YAP1/IFI16/ATM/NUCKS1/CLOCK 7 GO:1901880 negative regulation of protein depolymerization 7/803 72/18722 0.0343904783211595 0.138394612517596 MAP1B/PLEKHH2/LMOD1/SPTBN1/EPS8/TAOK1/GSN 7 GO:1904062 regulation of cation transmembrane transport 23/803 357/18722 0.0347711594161817 0.139713160814521 FHL1/THY1/FXYD1/BIN1/FLNA/HSPA2/ATP1B1/PTEN/CD63/CAMK2D/PKD2/PRNP/AHNAK/TWIST1/SESTD1/ITGB1/IFNGR2/ABL1/WNK1/DAPK1/STOM/SLC8A1/ACTN4 23 GO:1901214 regulation of neuron death 21/803 319/18722 0.0347741742019294 0.139713160814521 CSF1/ITGA1/APOE/ANGPT1/EFNB2/SERPINF1/GPNMB/MDK/LRP1/AXL/CLU/EGLN3/PRNP/NUPR1/ABL1/AP2B1/HLA-F/CAPN2/FOXO3/STAT3/GCLM 21 GO:0006694 steroid biosynthetic process 13/803 173/18722 0.0356660365823612 0.143181045410349 BMP5/HSD17B2/DKK3/SNAI2/APOE/PRLR/CES1/TSPO/H6PD/CYB5R3/OSBPL1A/PRKAA1/MBTPS1 13 GO:0032944 regulation of mononuclear cell proliferation 16/803 227/18722 0.0358174004749899 0.143557523125643 IGFBP2/VCAM1/CSF1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/PRKAR1A/SOS1/ATM/NDFIP1 16 GO:0098657 import into cell 16/803 227/18722 0.0358174004749899 0.143557523125643 SLC22A3/SPX/CD36/THBS1/CYBRD1/SLC2A10/STEAP4/ATP1B1/SLC9A9/SLC39A6/PRNP/ITGB1/SLC5A3/WNK1/SLC39A4/SLC8A1 16 GO:0031952 regulation of protein autophosphorylation 5/803 43/18722 0.0359340429159438 0.14367853887642 ENPP1/GPNMB/RAP2A/ENG/RAP2B 5 GO:0060443 mammary gland morphogenesis 5/803 43/18722 0.0359340429159438 0.14367853887642 IGFBP5/CSF1/TBX2/BMP4/TGFBR2 5 GO:0071604 transforming growth factor beta production 5/803 43/18722 0.0359340429159438 0.14367853887642 LUM/GATA6/THBS1/LAPTM4B/LTBP3 5 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/803 209/18722 0.0360174117175479 0.143896486236934 HGF/F3/GAS6/THBS1/CRYAB/UACA/ROBO1/EGLN3/DLC1/KLF4/PLAUR/DAPK1/GSN/SERPINB9/USP47 15 GO:0086003 cardiac muscle cell contraction 7/803 73/18722 0.0366887140256216 0.146461111394515 STC1/GATA4/GJA1/BIN1/FLNA/CAMK2D/GSN 7 GO:0002688 regulation of leukocyte chemotaxis 10/803 122/18722 0.0370372080203745 0.147605506279266 RARRES2/SLIT2/CSF1/GAS6/THBS1/CMKLR1/MDK/DPP4/WNK1/MTUS1 10 GO:0051928 positive regulation of calcium ion transport 10/803 122/18722 0.0370372080203745 0.147605506279266 STC1/THY1/PDGFRB/MYLK/HSPA2/ATP1B1/CASK/PKD2/TSPO/ABL1 10 GO:0010657 muscle cell apoptotic process 8/803 89/18722 0.0370641985282071 0.147605506279266 HAND2/GATA4/PTEN/CAMK2D/MDK/LRP6/NUPR1/CAPN2 8 GO:0001659 temperature homeostasis 13/803 174/18722 0.0371014449791401 0.14763591753072 ADAMTS5/LAMA4/CD36/MFAP2/EDNRB/PRLR/GJA1/CMKLR1/THRA/EPAS1/LPIN1/STAT3/LNPEP 13 GO:0006869 lipid transport 25/803 398/18722 0.0371424330127067 0.14768115709837 APOD/PLA2G2A/SPX/ABCA8/CD36/THBS1/PLSCR4/APOE/CES1/LRP1/APOL1/PLTP/CLU/TSPO/LRP6/APOL6/SCARB2/PDZD8/PLA2R1/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/ESYT2 25 GO:0045637 regulation of myeloid cell differentiation 15/803 210/18722 0.0373206311183656 0.148271447614479 CSF1/KITLG/PRKCA/ACVR2A/MEIS2/B2M/PIK3R1/ZFP36L1/NOTCH2/FBN1/GPR137B/JAG1/FOXO3/STAT3/NDFIP1 15 GO:2000649 regulation of sodium ion transmembrane transporter activity 6/803 58/18722 0.0373510141256941 0.148274009897063 FXYD1/ATP1B1/CAMK2D/WNK1/STOM/ACTN4 6 GO:0034368 protein-lipid complex remodeling 4/803 30/18722 0.037968937350681 0.149654641605135 PLA2G2A/APOE/PLTP/ABCA5 4 GO:0034369 plasma lipoprotein particle remodeling 4/803 30/18722 0.037968937350681 0.149654641605135 PLA2G2A/APOE/PLTP/ABCA5 4 GO:0034694 response to prostaglandin 4/803 30/18722 0.037968937350681 0.149654641605135 PTGFR/PTGER2/TGFBR3/PRKAA1 4 GO:0044788 modulation by host of viral process 4/803 30/18722 0.037968937350681 0.149654641605135 APOE/IGF2R/STOM/NUCKS1 4 GO:0045939 negative regulation of steroid metabolic process 4/803 30/18722 0.037968937350681 0.149654641605135 BMP5/DKK3/SNAI2/APOE 4 GO:0051125 regulation of actin nucleation 4/803 30/18722 0.037968937350681 0.149654641605135 ABI2/NCKAP1/WASL/GSN 4 GO:0060218 hematopoietic stem cell differentiation 4/803 30/18722 0.037968937350681 0.149654641605135 MLLT3/EXT1/ABL1/N4BP2L2 4 GO:1903579 negative regulation of ATP metabolic process 4/803 30/18722 0.037968937350681 0.149654641605135 TSPO/NUPR1/PID1/STAT3 4 GO:2000648 positive regulation of stem cell proliferation 4/803 30/18722 0.037968937350681 0.149654641605135 KITLG/GJA1/LTBP3/N4BP2L2 4 GO:0046822 regulation of nucleocytoplasmic transport 9/803 106/18722 0.0384048904182443 0.15113400443991 APOD/GAS6/CD36/BMP4/ANGPT1/FLNA/RAB23/PIK3R1/PKIG 9 GO:2000278 regulation of DNA biosynthetic process 9/803 106/18722 0.0384048904182443 0.15113400443991 HGF/PDGFRB/SMOC2/GJA1/KLF4/BMPR2/TERF1/NEK7/ATM 9 GO:0031333 negative regulation of protein-containing complex assembly 11/803 140/18722 0.038641133398386 0.151943762716366 SLIT2/LMOD1/CRYAB/LDLRAD4/THRA/MYADM/SPTBN1/CLU/EIF4EBP1/EPS8/GSN 11 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 14/803 193/18722 0.0387624523808261 0.152300699425374 HGF/FGF7/ENPP2/VTN/KITLG/GAS6/CD36/ANGPT1/IL6ST/IGF2/CD81/PRNP/TNFRSF1A/ABL1 14 GO:0070972 protein localization to endoplasmic reticulum 7/803 74/18722 0.0390858809725256 0.153450553172451 MAN1A1/GJA1/TRAM1/SEC61A1/TRAM2/SEC62/RTN4 7 GO:0048066 developmental pigmentation 5/803 44/18722 0.0391643008261814 0.153607021546864 ENPP1/KITLG/EDNRB/ZEB2/CD63 5 GO:0002028 regulation of sodium ion transport 8/803 90/18722 0.0392181585297147 0.153607021546864 FXYD1/SERPINE2/ATP1B1/CAMK2D/WNK1/STOM/SLC8A1/ACTN4 8 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 8/803 90/18722 0.0392181585297147 0.153607021546864 MMP2/IGFBP5/EFEMP2/PRKG1/GJA1/ADAMTS1/PTEN/TPM1 8 GO:0002544 chronic inflammatory response 3/803 18/18722 0.0396620428480276 0.153655746418233 VCAM1/THBS1/GJA1 3 GO:0003128 heart field specification 3/803 18/18722 0.0396620428480276 0.153655746418233 BMP4/EXT1/ROBO1 3 GO:0010663 positive regulation of striated muscle cell apoptotic process 3/803 18/18722 0.0396620428480276 0.153655746418233 PTEN/CAMK2D/CAPN2 3 GO:0010666 positive regulation of cardiac muscle cell apoptotic process 3/803 18/18722 0.0396620428480276 0.153655746418233 PTEN/CAMK2D/CAPN2 3 GO:0060192 negative regulation of lipase activity 3/803 18/18722 0.0396620428480276 0.153655746418233 ABL1/PLA2R1/SORT1 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/803 18/18722 0.0396620428480276 0.153655746418233 BMP4/BMPR2/DAB2 3 GO:0060438 trachea development 3/803 18/18722 0.0396620428480276 0.153655746418233 RSPO2/BMP4/TGFBR2 3 GO:0061484 hematopoietic stem cell homeostasis 3/803 18/18722 0.0396620428480276 0.153655746418233 GLIS2/EXT1/FSTL1 3 GO:0072234 metanephric nephron tubule development 3/803 18/18722 0.0396620428480276 0.153655746418233 PKD1/PKD2/YAP1 3 GO:0080182 histone H3-K4 trimethylation 3/803 18/18722 0.0396620428480276 0.153655746418233 KMT2A/KMT2E/RTF1 3 GO:0097094 craniofacial suture morphogenesis 3/803 18/18722 0.0396620428480276 0.153655746418233 BMP4/RAB23/TWIST1 3 GO:1900006 positive regulation of dendrite development 3/803 18/18722 0.0396620428480276 0.153655746418233 BMP5/TMEM106B/VLDLR 3 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/803 18/18722 0.0396620428480276 0.153655746418233 TNRC6C/ZFP36L2/ZFP36L1 3 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 3/803 18/18722 0.0396620428480276 0.153655746418233 HAND2/BMP4/BMPR2 3 GO:0051090 regulation of DNA-binding transcription factor activity 27/803 440/18722 0.0399968419241012 0.154759343396903 ENPP1/WNT2/NDN/CYTL1/DDR2/HAND2/GAS6/CD36/CMKLR1/PLPP3/FLNA/GLIS2/PTEN/PKD1/MTDH/CLU/PKD2/LRP6/PRNP/TWIST1/NUPR1/KLF4/PURA/ARID5B/STAT3/FER/CLOCK 27 GO:0043534 blood vessel endothelial cell migration 13/803 176/18722 0.0400947497324749 0.154759343396903 SLIT2/THBS1/APOE/FGFR1/ANGPT1/PRKCA/EFNB2/ROBO1/ITGB1/SPRED1/KLF4/ABL1/HSPB1 13 GO:0021885 forebrain cell migration 6/803 59/18722 0.0401331389916156 0.154759343396903 SLIT2/ROBO1/AXL/LAMB1/RTN4/ZMIZ1 6 GO:0030042 actin filament depolymerization 6/803 59/18722 0.0401331389916156 0.154759343396903 PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/GSN 6 GO:0046324 regulation of glucose import 6/803 59/18722 0.0401331389916156 0.154759343396903 ENPP1/GPC3/IRS1/PIK3R1/RHOQ/PID1 6 GO:2000351 regulation of endothelial cell apoptotic process 6/803 59/18722 0.0401331389916156 0.154759343396903 CD248/GAS6/THBS1/ANGPT1/ABL1/FOXO3 6 GO:0030183 B cell differentiation 11/803 141/18722 0.0403613648306585 0.155100451814827 VCAM1/LGALS1/PIK3R1/ZFP36L2/ZFP36L1/ITGB1/NOTCH2/ABL1/KLF6/SP3/ATM 11 GO:0034341 response to interferon-gamma 11/803 141/18722 0.0403613648306585 0.155100451814827 IFITM2/CLDN1/VIM/IFITM3/IFITM1/SEC61A1/BST2/IFNGR2/DAPK1/MYO1C/JAK1 11 GO:0005976 polysaccharide metabolic process 9/803 107/18722 0.0404082404547653 0.155100451814827 ENPP1/CSGALNACT1/CSGALNACT2/IL6ST/IGF2/IRS1/EXT1/CLTC/RB1CC1 9 GO:0042303 molting cycle 9/803 107/18722 0.0404082404547653 0.155100451814827 FGF7/IGFBP5/FST/LDB2/EXT1/APCDD1/ZDHHC21/SOS1/CLOCK 9 GO:0042633 hair cycle 9/803 107/18722 0.0404082404547653 0.155100451814827 FGF7/IGFBP5/FST/LDB2/EXT1/APCDD1/ZDHHC21/SOS1/CLOCK 9 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 9/803 107/18722 0.0404082404547653 0.155100451814827 SPON2/CD36/AKAP12/THBS1/CLU/PIK3R1/TWIST1/STAT3/HSPB1 9 GO:1990874 vascular associated smooth muscle cell proliferation 8/803 91/18722 0.0414541203735823 0.15887323791231 MMP2/IGFBP5/EFEMP2/PRKG1/GJA1/ADAMTS1/PTEN/TPM1 8 GO:0006644 phospholipid metabolic process 24/803 383/18722 0.0414548901973355 0.15887323791231 ENPP2/PLA2G2A/ABCA8/PDGFRB/GATA6/PLPP1/PLPP3/PTEN/SERINC1/PIK3R1/SOCS2/CISH/LPGAT1/AGPAT2/PLCB1/LPCAT2/SOCS3/SERINC3/LPIN1/CAPN2/SGMS1/SERINC5/ATM/IPMK 24 GO:0006613 cotranslational protein targeting to membrane 4/803 31/18722 0.0421662566712524 0.160857655518642 TRAM1/SEC61A1/TRAM2/SEC62 4 GO:0021988 olfactory lobe development 4/803 31/18722 0.0421662566712524 0.160857655518642 SLIT2/EXT1/ROBO1/SKI 4 GO:0030201 heparan sulfate proteoglycan metabolic process 4/803 31/18722 0.0421662566712524 0.160857655518642 CSGALNACT1/EXT1/UGDH/SULF2 4 GO:0043171 peptide catabolic process 4/803 31/18722 0.0421662566712524 0.160857655518642 ECE1/ANPEP/NPEPPS/LNPEP 4 GO:0051569 regulation of histone H3-K4 methylation 4/803 31/18722 0.0421662566712524 0.160857655518642 NNMT/KMT2A/KMT2E/RTF1 4 GO:0060795 cell fate commitment involved in formation of primary germ layer 4/803 31/18722 0.0421662566712524 0.160857655518642 GATA6/BMP4/KLF4/RTF1 4 GO:0046651 lymphocyte proliferation 19/803 288/18722 0.04228333214553 0.161060634320115 IGFBP2/VCAM1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/CD151/PRKAR1A/ABL1/PURA/MSN/SOS1/ATM/NDFIP1 19 GO:0051235 maintenance of location 21/803 326/18722 0.0422840694594926 0.161060634320115 ENPP1/THY1/CD36/APOE/GJA1/CES1/FLNA/CAMK2D/PKD1/PKD2/MEST/TSPO/FBN1/ABL1/HSP90B1/SYNE1/TPCN1/ARHGAP21/CCDC88A/SLC8A1/GSN 21 GO:0002832 negative regulation of response to biotic stimulus 9/803 108/18722 0.0424811218375372 0.161148783801461 HLA-B/SERPING1/HLA-A/HTRA1/A2M/HLA-F/IFI16/SERPINB9/TSPAN6 9 GO:0003254 regulation of membrane depolarization 5/803 45/18722 0.0425657738200007 0.161148783801461 DCN/FHL1/CAMK2D/TSPO/GCLM 5 GO:0022602 ovulation cycle process 5/803 45/18722 0.0425657738200007 0.161148783801461 PDGFRA/SLIT2/SLIT3/ADAMTS1/FOXO3 5 GO:0030835 negative regulation of actin filament depolymerization 5/803 45/18722 0.0425657738200007 0.161148783801461 PLEKHH2/LMOD1/SPTBN1/EPS8/GSN 5 GO:0030850 prostate gland development 5/803 45/18722 0.0425657738200007 0.161148783801461 HOXA13/BMP4/SERPINF1/PTEN/FRS2 5 GO:0031670 cellular response to nutrient 5/803 45/18722 0.0425657738200007 0.161148783801461 COL1A1/SNAI2/GAS6/KANK2/NCOA1 5 GO:0035272 exocrine system development 5/803 45/18722 0.0425657738200007 0.161148783801461 HGF/FGF7/TWSG1/IGF2/NFIB 5 GO:0048546 digestive tract morphogenesis 5/803 45/18722 0.0425657738200007 0.161148783801461 TCF21/PDGFRA/GATA4/BMP4/EPB41L5 5 GO:0018210 peptidyl-threonine modification 10/803 125/18722 0.0426101242272639 0.161194293928025 PRKCA/CAMK2D/CDC42BPA/ROCK2/TGFBR2/SPRED1/HIPK3/WNK1/GALNT1/HIPK1 10 GO:0055008 cardiac muscle tissue morphogenesis 6/803 60/18722 0.0430430569401994 0.162708629191686 WNT2/COL11A1/HEG1/TGFBR3/ENG/TPM1 6 GO:0030010 establishment of cell polarity 11/803 143/18722 0.043959621839132 0.166047480674176 MAP1B/FSCN1/GJA1/SPRY1/PTK7/PKD1/ROCK2/ITGB1/MSN/GSN/AMOTL2 11 GO:0043266 regulation of potassium ion transport 9/803 109/18722 0.0446243390901578 0.16843070000267 FHL1/BIN1/FLNA/ATP1B1/PTEN/CD63/PRNP/ITGB1/WNK1 9 GO:0010952 positive regulation of peptidase activity 14/803 197/18722 0.0447620519341378 0.16882268603904 F3/ANTXR1/PCOLCE/UACA/PCOLCE2/ROBO1/ROCK2/EGLN3/DLC1/FBLN1/DAPK1/STAT3/IFI16/GSN 14 GO:0009226 nucleotide-sugar biosynthetic process 3/803 19/18722 0.0456406548266922 0.170972430477751 PGM3/UGDH/UAP1 3 GO:0010744 positive regulation of macrophage derived foam cell differentiation 3/803 19/18722 0.0456406548266922 0.170972430477751 PLA2G2A/CSF1/CD36 3 GO:0032011 ARF protein signal transduction 3/803 19/18722 0.0456406548266922 0.170972430477751 FBXO8/PSD3/MAP4K4 3 GO:0032012 regulation of ARF protein signal transduction 3/803 19/18722 0.0456406548266922 0.170972430477751 FBXO8/PSD3/MAP4K4 3 GO:0044320 cellular response to leptin stimulus 3/803 19/18722 0.0456406548266922 0.170972430477751 PTEN/PID1/STAT3 3 GO:0051546 keratinocyte migration 3/803 19/18722 0.0456406548266922 0.170972430477751 FGF7/PTEN/MAP4K4 3 GO:0051571 positive regulation of histone H3-K4 methylation 3/803 19/18722 0.0456406548266922 0.170972430477751 KMT2A/KMT2E/RTF1 3 GO:1900221 regulation of amyloid-beta clearance 3/803 19/18722 0.0456406548266922 0.170972430477751 APOE/LRP1/CLU 3 GO:1903975 regulation of glial cell migration 3/803 19/18722 0.0456406548266922 0.170972430477751 CSF1/LRP1/CERS2 3 GO:0106106 cold-induced thermogenesis 11/803 144/18722 0.0458388423278093 0.171299333603838 ADAMTS5/LAMA4/CD36/MFAP2/PRLR/GJA1/CMKLR1/THRA/EPAS1/LPIN1/LNPEP 11 GO:0120161 regulation of cold-induced thermogenesis 11/803 144/18722 0.0458388423278093 0.171299333603838 ADAMTS5/LAMA4/CD36/MFAP2/PRLR/GJA1/CMKLR1/THRA/EPAS1/LPIN1/LNPEP 11 GO:0032409 regulation of transporter activity 20/803 310/18722 0.046032519784137 0.171299333603838 FHL1/FXYD1/GJA1/HSPA2/ATP1B1/PTEN/CAMK2D/PKD2/PRNP/AHNAK/TWIST1/ITGB1/IFNGR2/SLC5A3/KMT2A/WNK1/DAPK1/STOM/NDFIP1/ACTN4 20 GO:0034113 heterotypic cell-cell adhesion 6/803 61/18722 0.0460819410596908 0.171299333603838 VCAM1/THY1/MYADM/ITGB1/KLF4/WNK1 6 GO:0050994 regulation of lipid catabolic process 6/803 61/18722 0.0460819410596908 0.171299333603838 RARRES2/THRA/IRS1/PDE3B/TWIST1/PRKAA1 6 GO:0071384 cellular response to corticosteroid stimulus 6/803 61/18722 0.0460819410596908 0.171299333603838 STC1/SERPINF1/NR3C1/ZFP36L2/ZFP36L1/FOXO3 6 GO:0031018 endocrine pancreas development 5/803 46/18722 0.0461395865367531 0.171299333603838 BMP5/GATA6/BMP4/SIDT2/CLOCK 5 GO:0043462 regulation of ATPase activity 5/803 46/18722 0.0461395865367531 0.171299333603838 TPM2/ATP1B1/CNN3/PXK/TPM1 5 GO:0048701 embryonic cranial skeleton morphogenesis 5/803 46/18722 0.0461395865367531 0.171299333603838 PDGFRA/BMP4/RDH10/TWIST1/TGFBR2 5 GO:0055010 ventricular cardiac muscle tissue morphogenesis 5/803 46/18722 0.0461395865367531 0.171299333603838 COL11A1/HEG1/TGFBR3/ENG/TPM1 5 GO:0072599 establishment of protein localization to endoplasmic reticulum 5/803 46/18722 0.0461395865367531 0.171299333603838 MAN1A1/TRAM1/SEC61A1/TRAM2/SEC62 5 GO:0051591 response to cAMP 8/803 93/18722 0.0461758474811765 0.171299333603838 COL1A1/STC1/IGFBP5/SPARC/PKD2/ZFP36L1/SDC1/SLC8A1 8 GO:0060759 regulation of response to cytokine stimulus 12/803 162/18722 0.0464512179185376 0.171299333603838 SLIT2/ECM1/CSF1/SLIT3/GAS6/IL1R1/ANGPT1/ROBO1/AXL/AGPAT2/KLF4/HIPK1 12 GO:0007435 salivary gland morphogenesis 4/803 32/18722 0.0466146381608036 0.171299333603838 HGF/FGF7/TWSG1/NFIB 4 GO:0010644 cell communication by electrical coupling 4/803 32/18722 0.0466146381608036 0.171299333603838 GJA1/ATP1B1/CAMK2D/SLC8A1 4 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 4/803 32/18722 0.0466146381608036 0.171299333603838 HAND2/GATA4/MDK/NUPR1 4 GO:0010743 regulation of macrophage derived foam cell differentiation 4/803 32/18722 0.0466146381608036 0.171299333603838 PLA2G2A/CSF1/CD36/ABCA5 4 GO:0014044 Schwann cell development 4/803 32/18722 0.0466146381608036 0.171299333603838 LAMB2/NDRG1/PLEC/SKI 4 GO:0034367 protein-containing complex remodeling 4/803 32/18722 0.0466146381608036 0.171299333603838 PLA2G2A/APOE/PLTP/ABCA5 4 GO:0035767 endothelial cell chemotaxis 4/803 32/18722 0.0466146381608036 0.171299333603838 SMOC2/THBS1/FGFR1/HSPB1 4 GO:0045879 negative regulation of smoothened signaling pathway 4/803 32/18722 0.0466146381608036 0.171299333603838 ENPP1/SERPINE2/GPC3/GLIS2 4 GO:0051497 negative regulation of stress fiber assembly 4/803 32/18722 0.0466146381608036 0.171299333603838 PIK3R1/DLC1/ARHGAP28/TJP1 4 GO:0060914 heart formation 4/803 32/18722 0.0466146381608036 0.171299333603838 HAND2/BMP4/EXT1/ROBO1 4 GO:0061037 negative regulation of cartilage development 4/803 32/18722 0.0466146381608036 0.171299333603838 SNAI2/BMP4/CTSK/LTBP3 4 GO:1901532 regulation of hematopoietic progenitor cell differentiation 4/803 32/18722 0.0466146381608036 0.171299333603838 KITLG/ABL1/N4BP2L2/SOS1 4 GO:2000116 regulation of cysteine-type endopeptidase activity 16/803 235/18722 0.0466211784397128 0.171299333603838 HGF/F3/GAS6/THBS1/CRYAB/UACA/ROBO1/EGLN3/DLC1/KLF4/PLAUR/DAPK1/IFI16/GSN/SERPINB9/USP47 16 GO:0031331 positive regulation of cellular catabolic process 26/803 427/18722 0.0466887792962518 0.171421394382262 DCN/APOE/PRICKLE1/KCNQ1OT1/TNRC6C/CD81/IRS1/PTEN/LRP1/MTDH/CLU/SESN3/ROCK2/TWIST1/ZFP36L2/NUPR1/ZFP36L1/TPCN1/DAPK1/DAB2/FOXO3/TMEM59/PRKAA1/MSN/BNIP3L/HECTD1 26 GO:1904659 glucose transmembrane transport 9/803 110/18722 0.046838648324928 0.171845107099405 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/SLC5A3/PID1/SORT1 9 GO:0031016 pancreas development 7/803 77/18722 0.0468827282637778 0.171880355237644 BMP5/GATA6/BMP4/IGF2/MEIS2/SIDT2/CLOCK 7 GO:0034249 negative regulation of cellular amide metabolic process 18/803 273/18722 0.0473530868626644 0.173477216089085 IGFBP5/SPON1/APOE/BIN1/TNRC6C/CLU/EIF4EBP1/ROCK2/PRNP/ZFP36L2/ZFP36L1/AGO3/RTN4/PURA/DAPK1/STAT3/PRKAA1/EIF4EBP2 18 GO:0010876 lipid localization 27/803 448/18722 0.0480622754332981 0.175946039141281 ENPP1/APOD/PLA2G2A/SPX/ABCA8/CD36/THBS1/PLSCR4/APOE/CES1/LRP1/APOL1/PLTP/CLU/MEST/TSPO/LRP6/APOL6/SCARB2/PDZD8/PLA2R1/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/ESYT2 27 GO:0071322 cellular response to carbohydrate stimulus 12/803 163/18722 0.0482808515661027 0.176616526712097 GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/LRP1/ZFP36L1/SIDT2/FOXO3/PRKAA1/MAP4K4/GCLM 12 GO:0051924 regulation of calcium ion transport 17/803 255/18722 0.048549207653921 0.177467998066313 STC1/THY1/PDGFRB/MYLK/GJA1/BIN1/HSPA2/ATP1B1/CASK/CAMK2D/PKD2/TSPO/PRNP/AHNAK/SESTD1/ABL1/SLC8A1 17 GO:0002042 cell migration involved in sprouting angiogenesis 8/803 94/18722 0.0486633336211094 0.17775485819403 SLIT2/THBS1/EFNB2/ROBO1/ITGB1/SPRED1/KLF4/ABL1 8 GO:0032615 interleukin-12 production 6/803 62/18722 0.0492507769249273 0.179374999085236 CD36/THBS1/CMKLR1/HLA-B/MDK/PLCB1 6 GO:0032655 regulation of interleukin-12 production 6/803 62/18722 0.0492507769249273 0.179374999085236 CD36/THBS1/CMKLR1/HLA-B/MDK/PLCB1 6 GO:0048002 antigen processing and presentation of peptide antigen 6/803 62/18722 0.0492507769249273 0.179374999085236 HLA-B/HLA-A/HLA-C/B2M/HLA-F/LNPEP 6 GO:1903078 positive regulation of protein localization to plasma membrane 6/803 62/18722 0.0492507769249273 0.179374999085236 EPHA3/SPTBN1/LRP1/PIK3R1/PRNP/ITGB1 6 GO:0032371 regulation of sterol transport 7/803 78/18722 0.0496868278186662 0.180699141870073 ABCA8/APOE/CES1/LRP1/PLTP/TSPO/ABCA5 7 GO:0032374 regulation of cholesterol transport 7/803 78/18722 0.0496868278186662 0.180699141870073 ABCA8/APOE/CES1/LRP1/PLTP/TSPO/ABCA5 7 GO:0001754 eye photoreceptor cell differentiation 5/803 47/18722 0.0498865149762382 0.180766107319421 THY1/PROM1/TUG1/STAT3/CEP290 5 GO:0045646 regulation of erythrocyte differentiation 5/803 47/18722 0.0498865149762382 0.180766107319421 ACVR2A/B2M/ZFP36L1/FOXO3/STAT3 5 GO:0048483 autonomic nervous system development 5/803 47/18722 0.0498865149762382 0.180766107319421 VCAM1/HAND2/EDNRB/NRP2/NAV2 5 GO:0050798 activated T cell proliferation 5/803 47/18722 0.0498865149762382 0.180766107319421 IGFBP2/IGF2/PRNP/PRKAR1A/ABL1 5 GO:0090279 regulation of calcium ion import 5/803 47/18722 0.0498865149762382 0.180766107319421 STC1/PDGFRB/CASK/PKD2/PRNP 5 GO:0043270 positive regulation of ion transport 18/803 275/18722 0.050175905922208 0.181682692032047 STC1/FHL1/THY1/PDGFRB/FXYD1/MYLK/FLNA/HSPA2/ATP1B1/CASK/PKD2/TSPO/ITGB1/IFNGR2/ABL1/PLA2R1/WNK1/ACTN4 18 GO:0034764 positive regulation of transmembrane transport 15/803 219/18722 0.0506101622541197 0.183122111029783 THY1/FXYD1/GPC3/FLNA/HSPA2/ATP1B1/IRS1/PKD2/PIK3R1/ITGB1/RHOQ/IFNGR2/ABL1/WNK1/ACTN4 15 GO:0008593 regulation of Notch signaling pathway 8/803 95/18722 0.0512362605407519 0.185253078358368 DLK1/IL6ST/TSPAN5/ROBO1/YAP1/JAG1/STAT3/ZMIZ1 8 GO:0048333 mesodermal cell differentiation 4/803 33/18722 0.0513133554969152 0.185263135776697 BMP4/GJA1/ITGB1/KLF4 4 GO:0071295 cellular response to vitamin 4/803 33/18722 0.0513133554969152 0.185263135776697 COL1A1/SNAI2/GAS6/KANK2 4 GO:0002526 acute inflammatory response 9/803 112/18722 0.0514833181984152 0.18560797146587 F3/VCAM1/EDNRB/OSMR/IL6ST/EXT1/NUPR1/ASH1L/STAT3 9 GO:0035601 protein deacylation 9/803 112/18722 0.0514833181984152 0.18560797146587 NDN/NNMT/FLNA/CAMK2D/SPRED1/TBL1XR1/SKI/PRKAA1/MIER1 9 GO:0060041 retina development in camera-type eye 11/803 147/18722 0.0518034970426996 0.186123083411544 PDGFRA/THY1/LAMC3/PDGFRB/PROM1/COL4A1/SERPINF1/LAMB2/BMPR2/SKI/HIPK1 11 GO:0003215 cardiac right ventricle morphogenesis 3/803 20/18722 0.0520368187476317 0.186123083411544 HAND2/GATA4/JAG1 3 GO:0006700 C21-steroid hormone biosynthetic process 3/803 20/18722 0.0520368187476317 0.186123083411544 BMP5/DKK3/TSPO 3 GO:0006883 cellular sodium ion homeostasis 3/803 20/18722 0.0520368187476317 0.186123083411544 C7/ATP1B1/SLC8A1 3 GO:0007620 copulation 3/803 20/18722 0.0520368187476317 0.186123083411544 SERPINE2/EDNRB/ACVR2A 3 GO:0031645 negative regulation of nervous system process 3/803 20/18722 0.0520368187476317 0.186123083411544 TMEM98/PTEN/LPIN1 3 GO:0043011 myeloid dendritic cell differentiation 3/803 20/18722 0.0520368187476317 0.186123083411544 TGFBR2/NOTCH2/LTBR 3 GO:0051900 regulation of mitochondrial depolarization 3/803 20/18722 0.0520368187476317 0.186123083411544 DCN/TSPO/GCLM 3 GO:0060044 negative regulation of cardiac muscle cell proliferation 3/803 20/18722 0.0520368187476317 0.186123083411544 GJA1/PTEN/TGFBR2 3 GO:0071379 cellular response to prostaglandin stimulus 3/803 20/18722 0.0520368187476317 0.186123083411544 PTGFR/PTGER2/PRKAA1 3 GO:0097320 plasma membrane tubulation 3/803 20/18722 0.0520368187476317 0.186123083411544 EHD2/ASAP1/WASL 3 GO:0097529 myeloid leukocyte migration 15/803 220/18722 0.0522668477479077 0.186811830015102 RARRES2/SLIT2/CSF1/EMILIN1/ITGA1/THBS1/EDNRB/IL1R1/CMKLR1/CD9/CD81/MDK/DPP4/PLCB1/MTUS1 15 GO:0010038 response to metal ion 23/803 373/18722 0.0523538418911117 0.186988721825991 IGFBP2/VCAM1/FIBIN/SPARC/THBS1/KCNMA1/CYBRD1/SOD3/SLC39A13/CLDN1/SERPINF1/PTEN/CAMK2D/B2M/PKD2/TSPO/PRNP/NDRG1/TXNIP/SEC31A/SDC1/WNK1/PRKAA1 23 GO:0002704 negative regulation of leukocyte mediated immunity 6/803 63/18722 0.0525503620528535 0.187556267140678 HLA-B/HLA-A/BST2/HLA-F/SERPINB9/NDFIP1 6 GO:0009896 positive regulation of catabolic process 29/803 492/18722 0.0526522343356299 0.187785436621925 DCN/GPC3/APOE/GJA1/PRICKLE1/KCNQ1OT1/TNRC6C/CD81/IRS1/PTEN/LRP1/MTDH/CLU/SESN3/ROCK2/TWIST1/ZFP36L2/NUPR1/ZFP36L1/TPCN1/DAPK1/DAB2/FOXO3/TMEM59/PRKAA1/MSN/BNIP3L/HECTD1/NDFIP1 29 GO:0032388 positive regulation of intracellular transport 14/803 202/18722 0.0531419093062144 0.189396397284335 EHD2/GAS6/FLNA/CD81/PIK3R1/PRNP/NPEPPS/DAB2/SAR1A/STOM/PRKAA1/MYO1C/MSN/CEP290 14 GO:0010769 regulation of cell morphogenesis involved in differentiation 8/803 96/18722 0.0538953045475891 0.191807272287137 PDPN/PTPRD/MYADM/FLNA/MDK/ABL1/FBLN1/ACTN4 8 GO:0044264 cellular polysaccharide metabolic process 8/803 96/18722 0.0538953045475891 0.191807272287137 ENPP1/CSGALNACT1/CSGALNACT2/IL6ST/IGF2/IRS1/EXT1/RB1CC1 8 GO:0043112 receptor metabolic process 12/803 166/18722 0.0540642160651232 0.192271170685238 CD36/APOE/ANGPT1/ECE1/RAMP1/CD9/CD81/CD63/LRP1/ITGB1/AP2B1/CLTC 12 GO:0019827 stem cell population maintenance 10/803 131/18722 0.0554099200357394 0.196776254485895 LDB2/YAP1/ZFP36L2/NOTCH2/KLF4/JAG1/FOXO3/SKI/STAT3/RTF1 10 GO:1904950 negative regulation of establishment of protein localization 10/803 131/18722 0.0554099200357394 0.196776254485895 APOD/CD36/APOE/ANGPT1/IRS1/RAB23/PKIG/MAP4K4/TERF1/NDFIP1 10 GO:0010506 regulation of autophagy 20/803 317/18722 0.0555047590558314 0.196972760606673 DCN/HGF/GATA4/MTDH/TSPO/SESN3/NUPR1/ABL1/GPR137B/TPCN1/DAPK1/FOXO3/STAT3/TMEM59/PRKAA1/BNIP3L/IFI16/ATM/CTSA/HSPB1 20 GO:0043433 negative regulation of DNA-binding transcription factor activity 13/803 185/18722 0.0556786960337246 0.197449486788159 NDN/HAND2/GAS6/CMKLR1/FLNA/GLIS2/PKD1/PKD2/PRNP/TWIST1/NUPR1/KLF4/PURA 13 GO:0030837 negative regulation of actin filament polymerization 6/803 64/18722 0.0559813059275538 0.198099922891968 SLIT2/LMOD1/MYADM/SPTBN1/EPS8/GSN 6 GO:0046854 phosphatidylinositol phosphate biosynthetic process 6/803 64/18722 0.0559813059275538 0.198099922891968 PIK3R1/SOCS2/CISH/SOCS3/ATM/IPMK 6 GO:0070542 response to fatty acid 6/803 64/18722 0.0559813059275538 0.198099922891968 CD36/CLDN1/IRS1/PDK4/PID1/FOXO3 6 GO:0045834 positive regulation of lipid metabolic process 11/803 149/18722 0.0560574054003699 0.198105381850392 PDGFRA/PDGFRB/APOE/CES1/RDH10/CD81/IRS1/LPGAT1/TWIST1/CAPN2/PRKAA1 11 GO:0007254 JNK cascade 12/803 167/18722 0.0560915711896535 0.198105381850392 CDC42EP5/MFHAS1/PLCB1/RAP2A/TAOK1/HIPK3/MAGI3/ZMYND11/MAP4K4/PJA2/RB1CC1/LTBR 12 GO:0044843 cell cycle G1/S phase transition 16/803 241/18722 0.0561094075847556 0.198105381850392 CCND2/FHL1/KANK2/ADAMTS1/PTEN/CDK18/GPNMB/PKD1/PKD2/EIF4EBP1/PLCB1/ITGB1/KLF4/BACH1/KMT2E/ATM 16 GO:0001662 behavioral fear response 4/803 34/18722 0.0562609748696661 0.198105381850392 APOE/GJA1/MDK/DPP4 4 GO:0007431 salivary gland development 4/803 34/18722 0.0562609748696661 0.198105381850392 HGF/FGF7/TWSG1/NFIB 4 GO:0007616 long-term memory 4/803 34/18722 0.0562609748696661 0.198105381850392 CCND2/APOE/PRNP/PJA2 4 GO:0086004 regulation of cardiac muscle cell contraction 4/803 34/18722 0.0562609748696661 0.198105381850392 STC1/GATA4/BIN1/CAMK2D 4 GO:0008645 hexose transmembrane transport 9/803 114/18722 0.0564201698725549 0.198525735345489 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/SLC5A3/PID1/SORT1 9 GO:0010596 negative regulation of endothelial cell migration 8/803 97/18722 0.0566410663097796 0.198881941282085 DCN/STC1/SLIT2/THBS1/APOE/SERPINF1/SPRED1/KLF4 8 GO:0120162 positive regulation of cold-induced thermogenesis 8/803 97/18722 0.0566410663097796 0.198881941282085 CD36/MFAP2/PRLR/GJA1/CMKLR1/THRA/EPAS1/LPIN1 8 GO:1901216 positive regulation of neuron death 8/803 97/18722 0.0566410663097796 0.198881941282085 ITGA1/EFNB2/CLU/PRNP/NUPR1/ABL1/CAPN2/FOXO3 8 GO:0002274 myeloid leukocyte activation 15/803 223/18722 0.0574615148416266 0.201620769176883 PTGDS/PLA2G2A/CSF1/THBS1/MFHAS1/CLU/TGFBR2/NDRG1/NOTCH2/IFNGR2/GPR137B/FER/KMT2E/PJA2/LTBR 15 GO:0071478 cellular response to radiation 13/803 186/18722 0.0576321766797342 0.202077378990967 CCND2/MMP2/MFAP4/CRYAB/TIMP1/PTPRK/PIK3R1/YAP1/IFI16/ATM/NUCKS1/CLOCK/USP47 13 GO:0034332 adherens junction organization 5/803 49/18722 0.0579011095183325 0.20230899233245 CDH11/PLEC/VCL/HIPK1/TJP1 5 GO:0045778 positive regulation of ossification 5/803 49/18722 0.0579011095183325 0.20230899233245 BMP4/OSR2/ACVR2A/BMPR2/SLC8A1 5 GO:0046580 negative regulation of Ras protein signal transduction 5/803 49/18722 0.0579011095183325 0.20230899233245 HEG1/SPRY1/ITGB1/DLC1/TIMP2 5 GO:0070169 positive regulation of biomineral tissue development 5/803 49/18722 0.0579011095183325 0.20230899233245 BMP4/OSR2/ACVR2A/BMPR2/SLC8A1 5 GO:1904752 regulation of vascular associated smooth muscle cell migration 5/803 49/18722 0.0579011095183325 0.20230899233245 IGFBP5/PRKG1/ADAMTS1/LRP1/TPM1 5 GO:1902806 regulation of cell cycle G1/S phase transition 12/803 168/18722 0.0581693605007692 0.203027379555731 CCND2/FHL1/KANK2/ADAMTS1/PTEN/GPNMB/PKD1/PKD2/PLCB1/KLF4/KMT2E/ATM 12 GO:0001959 regulation of cytokine-mediated signaling pathway 11/803 150/18722 0.0582689455975825 0.203027379555731 SLIT2/ECM1/CSF1/SLIT3/GAS6/IL1R1/ANGPT1/ROBO1/AXL/AGPAT2/HIPK1 11 GO:0021954 central nervous system neuron development 7/803 81/18722 0.0587255611861209 0.203027379555731 CDH11/SLIT2/NFIB/PTEN/NRP2/NIN/ZMIZ1 7 GO:0007617 mating behavior 3/803 21/18722 0.0588396637501066 0.203027379555731 THRA/PTEN/NCOA1 3 GO:0010766 negative regulation of sodium ion transport 3/803 21/18722 0.0588396637501066 0.203027379555731 SERPINE2/CAMK2D/WNK1 3 GO:0030502 negative regulation of bone mineralization 3/803 21/18722 0.0588396637501066 0.203027379555731 ENPP1/ECM1/LTBP3 3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 3/803 21/18722 0.0588396637501066 0.203027379555731 ABI2/NCKAP1/WASL 3 GO:0044342 type B pancreatic cell proliferation 3/803 21/18722 0.0588396637501066 0.203027379555731 IGFBP5/NUPR1/SIDT2 3 GO:0045056 transcytosis 3/803 21/18722 0.0588396637501066 0.203027379555731 LRP1/FCGRT/CLTC 3 GO:0046641 positive regulation of alpha-beta T cell proliferation 3/803 21/18722 0.0588396637501066 0.203027379555731 HLA-A/CD81/TGFBR2 3 GO:0046885 regulation of hormone biosynthetic process 3/803 21/18722 0.0588396637501066 0.203027379555731 BMP5/DKK3/H6PD 3 GO:0060972 left/right pattern formation 3/803 21/18722 0.0588396637501066 0.203027379555731 PITX2/NOTCH2/EPB41L5 3 GO:0071498 cellular response to fluid shear stress 3/803 21/18722 0.0588396637501066 0.203027379555731 PKD2/KLF4/PLEC 3 GO:0072111 cell proliferation involved in kidney development 3/803 21/18722 0.0588396637501066 0.203027379555731 PDGFRB/BMP4/GPC3 3 GO:0072170 metanephric tubule development 3/803 21/18722 0.0588396637501066 0.203027379555731 PKD1/PKD2/YAP1 3 GO:0150146 cell junction disassembly 3/803 21/18722 0.0588396637501066 0.203027379555731 SNAI2/PIK3R1/MAP4K4 3 GO:1902644 tertiary alcohol metabolic process 3/803 21/18722 0.0588396637501066 0.203027379555731 BMP5/DKK3/H6PD 3 GO:2000291 regulation of myoblast proliferation 3/803 21/18722 0.0588396637501066 0.203027379555731 GATA6/MEIS2/MALAT1 3 GO:0046916 cellular transition metal ion homeostasis 9/803 115/18722 0.0589995093579366 0.203438142225914 CYBRD1/SLC39A13/STEAP4/SLC39A6/SLC40A1/PRNP/FRRS1/SLC39A4/NDFIP1 9 GO:2001234 negative regulation of apoptotic signaling pathway 15/803 224/18722 0.0592689022969575 0.204225809849779 HGF/BMP5/CREB3L1/SNAI2/GATA4/BMP4/THBS1/CLU/YAP1/PLAUR/ZMYND11/GCLM/RB1CC1/HSPB1/USP47 15 GO:0015909 long-chain fatty acid transport 6/803 65/18722 0.0595440305705438 0.204749335465332 PLA2G2A/SPX/CD36/THBS1/APOE/PLA2R1 6 GO:0033692 cellular polysaccharide biosynthetic process 6/803 65/18722 0.0595440305705438 0.204749335465332 ENPP1/CSGALNACT1/CSGALNACT2/IGF2/IRS1/EXT1 6 GO:0045453 bone resorption 6/803 65/18722 0.0595440305705438 0.204749335465332 CTSK/PRKCA/PDK4/EXT1/LTBP3/GPR137B 6 GO:0010565 regulation of cellular ketone metabolic process 10/803 133/18722 0.0601834795543461 0.206805533465175 BMP5/DKK3/CES1/RDH10/IRS1/PDK4/NCOR2/LPGAT1/TWIST1/H6PD 10 GO:0006937 regulation of muscle contraction 12/803 169/18722 0.0602979401253333 0.207056149769223 STC1/MYL9/SPX/PRKG1/GATA4/KCNMA1/BIN1/ATP1B1/CAMK2D/TPM1/SLC8A1/ZDHHC21 12 GO:0071333 cellular response to glucose stimulus 11/803 151/18722 0.0605374056857208 0.207735378354442 GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/LRP1/SIDT2/FOXO3/PRKAA1/MAP4K4/GCLM 11 GO:0050670 regulation of lymphocyte proliferation 15/803 225/18722 0.0611146561058113 0.209015402324052 IGFBP2/VCAM1/BMP4/IL6ST/TWSG1/IGF2/HLA-A/CD81/GPNMB/PRNP/TGFBR2/PRKAR1A/SOS1/ATM/NDFIP1 15 GO:0001893 maternal placenta development 4/803 35/18722 0.0614553910563699 0.209015402324052 STC1/GJA1/BMPR2/ASH1L 4 GO:0002209 behavioral defense response 4/803 35/18722 0.0614553910563699 0.209015402324052 APOE/GJA1/MDK/DPP4 4 GO:0003298 physiological muscle hypertrophy 4/803 35/18722 0.0614553910563699 0.209015402324052 SORBS2/GATA4/PDLIM5/AKAP13 4 GO:0003301 physiological cardiac muscle hypertrophy 4/803 35/18722 0.0614553910563699 0.209015402324052 SORBS2/GATA4/PDLIM5/AKAP13 4 GO:0010664 negative regulation of striated muscle cell apoptotic process 4/803 35/18722 0.0614553910563699 0.209015402324052 HAND2/GATA4/MDK/NUPR1 4 GO:0010765 positive regulation of sodium ion transport 4/803 35/18722 0.0614553910563699 0.209015402324052 FXYD1/ATP1B1/WNK1/ACTN4 4 GO:0032232 negative regulation of actin filament bundle assembly 4/803 35/18722 0.0614553910563699 0.209015402324052 PIK3R1/DLC1/ARHGAP28/TJP1 4 GO:0032350 regulation of hormone metabolic process 4/803 35/18722 0.0614553910563699 0.209015402324052 BMP5/DKK3/RDH10/H6PD 4 GO:0046640 regulation of alpha-beta T cell proliferation 4/803 35/18722 0.0614553910563699 0.209015402324052 TWSG1/HLA-A/CD81/TGFBR2 4 GO:0060236 regulation of mitotic spindle organization 4/803 35/18722 0.0614553910563699 0.209015402324052 PKD1/GNAI1/MAP9/CLTC 4 GO:0061049 cell growth involved in cardiac muscle cell development 4/803 35/18722 0.0614553910563699 0.209015402324052 SORBS2/GATA4/PDLIM5/AKAP13 4 GO:0090181 regulation of cholesterol metabolic process 4/803 35/18722 0.0614553910563699 0.209015402324052 APOE/CES1/PRKAA1/MBTPS1 4 GO:0015749 monosaccharide transmembrane transport 9/803 116/18722 0.0616534015666809 0.209260626420334 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/SLC5A3/PID1/SORT1 9 GO:0018107 peptidyl-threonine phosphorylation 9/803 116/18722 0.0616534015666809 0.209260626420334 PRKCA/CAMK2D/CDC42BPA/ROCK2/TGFBR2/SPRED1/HIPK3/WNK1/HIPK1 9 GO:0098732 macromolecule deacylation 9/803 116/18722 0.0616534015666809 0.209260626420334 NDN/NNMT/FLNA/CAMK2D/SPRED1/TBL1XR1/SKI/PRKAA1/MIER1 9 GO:0043242 negative regulation of protein-containing complex disassembly 7/803 82/18722 0.0619491334218333 0.210121346422626 MAP1B/PLEKHH2/LMOD1/SPTBN1/EPS8/TAOK1/GSN 7 GO:0001961 positive regulation of cytokine-mediated signaling pathway 5/803 50/18722 0.0621686328359026 0.210151053098177 CSF1/GAS6/IL1R1/AXL/AGPAT2 5 GO:0060337 type I interferon signaling pathway 5/803 50/18722 0.0621686328359026 0.210151053098177 IFITM2/IFITM3/IFITM1/IFNAR1/JAK1 5 GO:0071825 protein-lipid complex subunit organization 5/803 50/18722 0.0621686328359026 0.210151053098177 PLA2G2A/APOE/BIN1/PLTP/ABCA5 5 GO:0110151 positive regulation of biomineralization 5/803 50/18722 0.0621686328359026 0.210151053098177 BMP4/OSR2/ACVR2A/BMPR2/SLC8A1 5 GO:1904738 vascular associated smooth muscle cell migration 5/803 50/18722 0.0621686328359026 0.210151053098177 IGFBP5/PRKG1/ADAMTS1/LRP1/TPM1 5 GO:0007259 receptor signaling pathway via JAK-STAT 12/803 170/18722 0.0624776427113097 0.211052524768692 PTPRD/PRLR/IL6ST/PKD1/PKD2/SOCS2/SOCS3/TNFRSF1A/STAT3/FER/IFNAR1/JAK1 12 GO:0098727 maintenance of cell number 10/803 134/18722 0.062667396919234 0.211550197047597 LDB2/YAP1/ZFP36L2/NOTCH2/KLF4/JAG1/FOXO3/SKI/STAT3/RTF1 10 GO:0016125 sterol metabolic process 11/803 152/18722 0.0628631449084921 0.212067415773844 APOE/CES1/APOL1/CYB5R3/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/EBPL/MBTPS1 11 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 17/803 264/18722 0.0629988756065398 0.212381604985941 HGF/FGF7/ENPP2/THY1/VTN/KITLG/GAS6/CD36/ANGPT1/IL6ST/IGF2/CD81/PRNP/SOCS3/TNFRSF1A/RAP2B/ABL1 17 GO:0050922 negative regulation of chemotaxis 6/803 66/18722 0.0632387716311351 0.212902441156543 SLIT2/THBS1/SEMA3B/ROBO1/DPP4/SEMA6D 6 GO:2000573 positive regulation of DNA biosynthetic process 6/803 66/18722 0.0632387716311351 0.212902441156543 HGF/PDGFRB/SMOC2/KLF4/NEK7/ATM 6 GO:0031668 cellular response to extracellular stimulus 16/803 246/18722 0.0649742134114059 0.214781623676292 COL1A1/VCAM1/SNAI2/GAS6/KANK2/PDK4/AXL/SESN3/BMPR2/PLEC/SLC38A2/SLC39A4/FOXO3/PRKAA1/IFI16/NCOA1 16 GO:0002687 positive regulation of leukocyte migration 10/803 135/18722 0.0652165578721483 0.214781623676292 RARRES2/THY1/CSF1/KITLG/GAS6/THBS1/IL1R1/CMKLR1/MDK/WNK1 10 GO:0071331 cellular response to hexose stimulus 11/803 153/18722 0.0652464918064759 0.214781623676292 GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/LRP1/SIDT2/FOXO3/PRKAA1/MAP4K4/GCLM 11 GO:0050672 negative regulation of lymphocyte proliferation 7/803 83/18722 0.0652786714017521 0.214781623676292 BMP4/TWSG1/GPNMB/PRNP/PRKAR1A/ATM/NDFIP1 7 GO:0051899 membrane depolarization 7/803 83/18722 0.0652786714017521 0.214781623676292 DCN/FHL1/CAMK2D/TSPO/ABL1/SLC8A1/GCLM 7 GO:0002934 desmosome organization 2/803 10/18722 0.0657935169513489 0.214781623676292 SNAI2/PRKCA 2 GO:0003129 heart induction 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP4/ROBO1 2 GO:0003183 mitral valve morphogenesis 2/803 10/18722 0.0657935169513489 0.214781623676292 TWIST1/BMPR2 2 GO:0007028 cytoplasm organization 2/803 10/18722 0.0657935169513489 0.214781623676292 ZMIZ1/SOS1 2 GO:0010172 embryonic body morphogenesis 2/803 10/18722 0.0657935169513489 0.214781623676292 PHLDB1/ZNF281 2 GO:0015911 long-chain fatty acid import across plasma membrane 2/803 10/18722 0.0657935169513489 0.214781623676292 CD36/THBS1 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/803 10/18722 0.0657935169513489 0.214781623676292 P4HA2/EGLN3 2 GO:0019062 virion attachment to host cell 2/803 10/18722 0.0657935169513489 0.214781623676292 GAS6/CD81 2 GO:0021932 hindbrain radial glia guided cell migration 2/803 10/18722 0.0657935169513489 0.214781623676292 FLNA/ITGB1 2 GO:0032342 aldosterone biosynthetic process 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP5/DKK3 2 GO:0035376 sterol import 2/803 10/18722 0.0657935169513489 0.214781623676292 CD36/LRP1 2 GO:0036363 transforming growth factor beta activation 2/803 10/18722 0.0657935169513489 0.214781623676292 GATA6/LTBP3 2 GO:0043084 penile erection 2/803 10/18722 0.0657935169513489 0.214781623676292 EDNRB/ACVR2A 2 GO:0045843 negative regulation of striated muscle tissue development 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP4/TWIST1 2 GO:0050861 positive regulation of B cell receptor signaling pathway 2/803 10/18722 0.0657935169513489 0.214781623676292 CD81/CMTM3 2 GO:0051409 response to nitrosative stress 2/803 10/18722 0.0657935169513489 0.214781623676292 GCLM/ATM 2 GO:0060272 embryonic skeletal joint morphogenesis 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP4/OSR2 2 GO:0061140 lung secretory cell differentiation 2/803 10/18722 0.0657935169513489 0.214781623676292 GATA6/NFIB 2 GO:0070508 cholesterol import 2/803 10/18722 0.0657935169513489 0.214781623676292 CD36/LRP1 2 GO:0070561 vitamin D receptor signaling pathway 2/803 10/18722 0.0657935169513489 0.214781623676292 SNAI2/KANK2 2 GO:0072178 nephric duct morphogenesis 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP4/GPC3 2 GO:0072203 cell proliferation involved in metanephros development 2/803 10/18722 0.0657935169513489 0.214781623676292 PDGFRB/GPC3 2 GO:0090647 modulation of age-related behavioral decline 2/803 10/18722 0.0657935169513489 0.214781623676292 B2M/PRNP 2 GO:0097105 presynaptic membrane assembly 2/803 10/18722 0.0657935169513489 0.214781623676292 PTPRD/PTEN 2 GO:0098917 retrograde trans-synaptic signaling 2/803 10/18722 0.0657935169513489 0.214781623676292 PLCB1/FARP1 2 GO:1901203 positive regulation of extracellular matrix assembly 2/803 10/18722 0.0657935169513489 0.214781623676292 EMILIN1/PHLDB1 2 GO:1902946 protein localization to early endosome 2/803 10/18722 0.0657935169513489 0.214781623676292 ROCK2/MSN 2 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 2/803 10/18722 0.0657935169513489 0.214781623676292 BIN1/ROCK2 2 GO:1903867 extraembryonic membrane development 2/803 10/18722 0.0657935169513489 0.214781623676292 BMP5/HTRA1 2 GO:2000121 regulation of removal of superoxide radicals 2/803 10/18722 0.0657935169513489 0.214781623676292 FBLN5/CD36 2 GO:2001223 negative regulation of neuron migration 2/803 10/18722 0.0657935169513489 0.214781623676292 COL3A1/STAT3 2 GO:0008211 glucocorticoid metabolic process 3/803 22/18722 0.066036949277127 0.214781623676292 BMP5/DKK3/H6PD 3 GO:0032816 positive regulation of natural killer cell activation 3/803 22/18722 0.066036949277127 0.214781623676292 GAS6/AXL/HLA-F 3 GO:0035024 negative regulation of Rho protein signal transduction 3/803 22/18722 0.066036949277127 0.214781623676292 HEG1/ITGB1/DLC1 3 GO:0035089 establishment of apical/basal cell polarity 3/803 22/18722 0.066036949277127 0.214781623676292 FSCN1/PTK7/MSN 3 GO:0035584 calcium-mediated signaling using intracellular calcium source 3/803 22/18722 0.066036949277127 0.214781623676292 VCAM1/PTGFR/PRNP 3 GO:0045540 regulation of cholesterol biosynthetic process 3/803 22/18722 0.066036949277127 0.214781623676292 APOE/PRKAA1/MBTPS1 3 GO:0046628 positive regulation of insulin receptor signaling pathway 3/803 22/18722 0.066036949277127 0.214781623676292 IGF2/IRS1/NUCKS1 3 GO:0051220 cytoplasmic sequestering of protein 3/803 22/18722 0.066036949277127 0.214781623676292 FLNA/PKD1/PKD2 3 GO:0055093 response to hyperoxia 3/803 22/18722 0.066036949277127 0.214781623676292 COL1A1/PDPN/PDGFRB 3 GO:0060965 negative regulation of gene silencing by miRNA 3/803 22/18722 0.066036949277127 0.214781623676292 KCNQ1OT1/NCOR2/STAT3 3 GO:0072574 hepatocyte proliferation 3/803 22/18722 0.066036949277127 0.214781623676292 MDK/SULF2/NOTCH2 3 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 3/803 22/18722 0.066036949277127 0.214781623676292 MDK/SULF2/NOTCH2 3 GO:0090280 positive regulation of calcium ion import 3/803 22/18722 0.066036949277127 0.214781623676292 STC1/PDGFRB/CASK 3 GO:0106118 regulation of sterol biosynthetic process 3/803 22/18722 0.066036949277127 0.214781623676292 APOE/PRKAA1/MBTPS1 3 GO:1900543 negative regulation of purine nucleotide metabolic process 3/803 22/18722 0.066036949277127 0.214781623676292 NUPR1/PID1/STAT3 3 GO:2000725 regulation of cardiac muscle cell differentiation 3/803 22/18722 0.066036949277127 0.214781623676292 BMP4/EFNB2/FRS2 3 GO:0071222 cellular response to lipopolysaccharide 14/803 209/18722 0.0665959931717164 0.215937893042185 SPON2/CD36/EDNRB/PLSCR4/PRKCA/VIM/TFPI/AXL/MTDH/TSPO/ABL1/CAPN2/SGMS1/LITAF 14 GO:0010656 negative regulation of muscle cell apoptotic process 5/803 51/18722 0.0666090011028642 0.215937893042185 HAND2/GATA4/MDK/LRP6/NUPR1 5 GO:0014009 glial cell proliferation 5/803 51/18722 0.0666090011028642 0.215937893042185 CSF1/CLU/TSPO/SKI/CERS2 5 GO:0045661 regulation of myoblast differentiation 5/803 51/18722 0.0666090011028642 0.215937893042185 IGFBP3/BMP4/PRICKLE1/PLCB1/ZFP36L1 5 GO:0046850 regulation of bone remodeling 5/803 51/18722 0.0666090011028642 0.215937893042185 PRKCA/PDK4/MDK/LTBP3/GPR137B 5 GO:0002691 regulation of cellular extravasation 4/803 36/18722 0.0668938644706612 0.216298838035484 THY1/IL1R1/MDK/PLCB1 4 GO:0009225 nucleotide-sugar metabolic process 4/803 36/18722 0.0668938644706612 0.216298838035484 CSGALNACT1/PGM3/UGDH/UAP1 4 GO:0097009 energy homeostasis 4/803 36/18722 0.0668938644706612 0.216298838035484 CD36/METRNL/STAT3/PRKAA1 4 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 4/803 36/18722 0.0668938644706612 0.216298838035484 SNAI2/CLU/SKIL/USP47 4 GO:0042130 negative regulation of T cell proliferation 6/803 67/18722 0.0670655799709761 0.216713533204982 BMP4/TWSG1/GPNMB/PRNP/PRKAR1A/NDFIP1 6 GO:0034219 carbohydrate transmembrane transport 9/803 118/18722 0.0671863468171728 0.216963164009342 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/SLC5A3/PID1/SORT1 9 GO:0071326 cellular response to monosaccharide stimulus 11/803 154/18722 0.0676877437856693 0.218440835285014 GATA4/GAS6/CAMK2N1/LGALS1/SERPINF1/LRP1/SIDT2/FOXO3/PRKAA1/MAP4K4/GCLM 11 GO:0032370 positive regulation of lipid transport 7/803 84/18722 0.0687143822611792 0.221181349228044 ABCA8/APOE/CES1/LRP1/PLTP/PLA2R1/ABCA5 7 GO:0032945 negative regulation of mononuclear cell proliferation 7/803 84/18722 0.0687143822611792 0.221181349228044 BMP4/TWSG1/GPNMB/PRNP/PRKAR1A/ATM/NDFIP1 7 GO:0042310 vasoconstriction 7/803 84/18722 0.0687143822611792 0.221181349228044 EDNRB/ACTA2/GJA1/ECE1/BMPR2/SLC8A1/ZDHHC21 7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7/803 84/18722 0.0687143822611792 0.221181349228044 FHL1/KANK2/PTEN/GPNMB/PKD2/KLF4/ATM 7 GO:0006650 glycerophospholipid metabolic process 19/803 306/18722 0.0688392877265106 0.221440444260892 ENPP2/PLA2G2A/PDGFRB/PTEN/SERINC1/PIK3R1/SOCS2/CISH/LPGAT1/AGPAT2/PLCB1/LPCAT2/SOCS3/SERINC3/LPIN1/CAPN2/SERINC5/ATM/IPMK 19 GO:0071356 cellular response to tumor necrosis factor 15/803 229/18722 0.0688861720894544 0.22144839074018 COL1A1/VCAM1/GAS6/AKAP12/THBS1/CLDN1/EXT1/ZFP36L2/ZFP36L1/TNFRSF1A/PID1/SGMS1/FOXO3/HIPK1/ACTN4 15 GO:0045786 negative regulation of cell cycle 23/803 385/18722 0.0691886182682641 0.222277352245854 FHL1/BMP4/KANK2/CAMK2N1/GAS1/PTEN/GPNMB/PKD2/PTPRK/APBB2/ZFP36L2/NUPR1/ZFP36L1/KLF4/PRKAR1A/ABL1/TAOK1/TIMP2/ATRX/TERF1/ATM/CLOCK/USP47 23 GO:0006606 protein import into nucleus 11/803 155/18722 0.070187166724346 0.225340124460778 APOD/CD36/BMP4/ANGPT1/PRICKLE1/FLNA/RAB23/PIK3R1/TXNIP/PKIG/STAT3 11 GO:0006986 response to unfolded protein 10/803 137/18722 0.0705118209514115 0.226091279269285 CREB3L1/THBS1/HSPA2/TRAM1/SERPINH1/PIK3R1/AMFR/CREBRF/MBTPS1/HSPB1 10 GO:0008203 cholesterol metabolic process 10/803 137/18722 0.0705118209514115 0.226091279269285 APOE/CES1/APOL1/CYB5R3/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/MBTPS1 10 GO:0050807 regulation of synapse organization 14/803 211/18722 0.0708211729565232 0.226937254730864 FLRT3/PTPRD/SPARC/AMIGO2/APOE/PTEN/PDLIM5/NRP2/PRNP/ABI2/ABL1/CLSTN1/ITSN1/FARP1 14 GO:0034394 protein localization to cell surface 6/803 68/18722 0.0710243237163209 0.227296070635158 FGF7/FBLN5/ANGPT1/FLNA/PTPRK/VCL 6 GO:1902305 regulation of sodium ion transmembrane transport 6/803 68/18722 0.0710243237163209 0.227296070635158 FXYD1/ATP1B1/CAMK2D/WNK1/STOM/ACTN4 6 GO:0035196 production of miRNAs involved in gene silencing by miRNA 5/803 52/18722 0.0712213397322388 0.227488532930777 BMP4/NCOR2/AGO3/STAT3/PUM2 5 GO:0045010 actin nucleation 5/803 52/18722 0.0712213397322388 0.227488532930777 LMOD1/ABI2/NCKAP1/WASL/GSN 5 GO:0071357 cellular response to type I interferon 5/803 52/18722 0.0712213397322388 0.227488532930777 IFITM2/IFITM3/IFITM1/IFNAR1/JAK1 5 GO:0016202 regulation of striated muscle tissue development 4/803 37/18722 0.0725730588482563 0.231065945988126 BMP4/IGF2/TWIST1/PRKAA1 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/803 37/18722 0.0725730588482563 0.231065945988126 ENPP1/IGF2/IRS1/CLTC 4 GO:0060416 response to growth hormone 4/803 37/18722 0.0725730588482563 0.231065945988126 IGFBP5/PIK3R1/SOCS2/STAT3 4 GO:0090218 positive regulation of lipid kinase activity 4/803 37/18722 0.0725730588482563 0.231065945988126 PDGFRA/PDGFRB/CD81/IRS1 4 GO:1905332 positive regulation of morphogenesis of an epithelium 4/803 37/18722 0.0725730588482563 0.231065945988126 BMP4/GJA1/MDK/ABL1 4 GO:0002761 regulation of myeloid leukocyte differentiation 9/803 120/18722 0.0730214558073507 0.232013732042207 CSF1/KITLG/PRKCA/PIK3R1/ZFP36L1/NOTCH2/FBN1/GPR137B/NDFIP1 9 GO:0003283 atrial septum development 3/803 23/18722 0.0736152675673429 0.232013732042207 GATA4/NOTCH2/BMPR2 3 GO:0006622 protein targeting to lysosome 3/803 23/18722 0.0736152675673429 0.232013732042207 CLU/SCARB2/SORT1 3 GO:0006929 substrate-dependent cell migration 3/803 23/18722 0.0736152675673429 0.232013732042207 SLIT2/ROBO1/EPB41L5 3 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 3/803 23/18722 0.0736152675673429 0.232013732042207 APOD/F3/LRP1 3 GO:0019430 removal of superoxide radicals 3/803 23/18722 0.0736152675673429 0.232013732042207 FBLN5/CD36/SOD3 3 GO:0030194 positive regulation of blood coagulation 3/803 23/18722 0.0736152675673429 0.232013732042207 F3/CD36/THBS1 3 GO:0034695 response to prostaglandin E 3/803 23/18722 0.0736152675673429 0.232013732042207 PTGER2/TGFBR3/PRKAA1 3 GO:0035162 embryonic hemopoiesis 3/803 23/18722 0.0736152675673429 0.232013732042207 KITLG/TGFBR2/KMT2A 3 GO:0045932 negative regulation of muscle contraction 3/803 23/18722 0.0736152675673429 0.232013732042207 PRKG1/KCNMA1/BIN1 3 GO:0045980 negative regulation of nucleotide metabolic process 3/803 23/18722 0.0736152675673429 0.232013732042207 NUPR1/PID1/STAT3 3 GO:0060384 innervation 3/803 23/18722 0.0736152675673429 0.232013732042207 VCAM1/SERPINE2/SULF2 3 GO:0060396 growth hormone receptor signaling pathway 3/803 23/18722 0.0736152675673429 0.232013732042207 PIK3R1/SOCS2/STAT3 3 GO:0071636 positive regulation of transforming growth factor beta production 3/803 23/18722 0.0736152675673429 0.232013732042207 LUM/GATA6/THBS1 3 GO:0072576 liver morphogenesis 3/803 23/18722 0.0736152675673429 0.232013732042207 MDK/SULF2/NOTCH2 3 GO:1900048 positive regulation of hemostasis 3/803 23/18722 0.0736152675673429 0.232013732042207 F3/CD36/THBS1 3 GO:0014013 regulation of gliogenesis 8/803 103/18722 0.0749606313456363 0.235955623667514 SERPINE2/TMEM98/BIN1/IL6ST/MDK/TSPO/SKI/CERS2 8 GO:0030148 sphingolipid biosynthetic process 8/803 103/18722 0.0749606313456363 0.235955623667514 ELOVL2/ABCA8/PLPP1/PLPP3/SGMS1/PRKAA1/CERS2/CERS6 8 GO:0051651 maintenance of location in cell 14/803 213/18722 0.0752190666107137 0.236619701711984 THY1/APOE/GJA1/CAMK2D/PKD2/TSPO/ABL1/HSP90B1/SYNE1/TPCN1/ARHGAP21/CCDC88A/SLC8A1/GSN 14 GO:0051250 negative regulation of lymphocyte activation 11/803 157/18722 0.07536142926567 0.236619701711984 BMP4/TWSG1/GPNMB/MDK/AXL/PRNP/PAG1/PRKAR1A/HLA-F/ATM/NDFIP1 11 GO:1990845 adaptive thermogenesis 11/803 157/18722 0.07536142926567 0.236619701711984 ADAMTS5/LAMA4/CD36/MFAP2/PRLR/GJA1/CMKLR1/THRA/EPAS1/LPIN1/LNPEP 11 GO:2000377 regulation of reactive oxygen species metabolic process 11/803 157/18722 0.07536142926567 0.236619701711984 FBLN5/PDGFRB/CD36/THBS1/CRYAB/TSPO/TGFBR2/SLC5A3/PID1/FOXO3/STAT3 11 GO:0002707 negative regulation of lymphocyte mediated immunity 5/803 53/18722 0.0760044691189305 0.237036068588221 HLA-B/HLA-A/HLA-F/SERPINB9/NDFIP1 5 GO:0043113 receptor clustering 5/803 53/18722 0.0760044691189305 0.237036068588221 THY1/APOE/FLNA/CD81/GSN 5 GO:0071320 cellular response to cAMP 5/803 53/18722 0.0760044691189305 0.237036068588221 STC1/IGFBP5/PKD2/ZFP36L1/SLC8A1 5 GO:0043244 regulation of protein-containing complex disassembly 9/803 121/18722 0.076052842555073 0.237036068588221 MAP1B/PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/TAOK1/SETX/GSN 9 GO:0050728 negative regulation of inflammatory response 12/803 176/18722 0.0766450139034458 0.237036068588221 HGF/WFDC1/APOE/MFHAS1/SERPINF1/MDK/SOCS3/TNFRSF1A/KLF4/ASH1L/METRNL/NDFIP1 12 GO:0030705 cytoskeleton-dependent intracellular transport 13/803 195/18722 0.0773043590120919 0.237036068588221 MAP1B/MYO1B/MYO10/MYO1E/DST/PURA/ARHGAP21/ARMCX3/WASL/MYO1C/CCDC88A/HSPB1/ACTN4 13 GO:0001967 suckling behavior 2/803 11/18722 0.0781884050362737 0.237036068588221 HAND2/GLS 2 GO:0002327 immature B cell differentiation 2/803 11/18722 0.0781884050362737 0.237036068588221 ABL1/ATM 2 GO:0003093 regulation of glomerular filtration 2/803 11/18722 0.0781884050362737 0.237036068588221 GAS6/GJA1 2 GO:0003174 mitral valve development 2/803 11/18722 0.0781884050362737 0.237036068588221 TWIST1/BMPR2 2 GO:0006527 arginine catabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 DDAH2/OAT 2 GO:0006705 mineralocorticoid biosynthetic process 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP5/DKK3 2 GO:0006971 hypotonic response 2/803 11/18722 0.0781884050362737 0.237036068588221 MYLK/TSPO 2 GO:0014010 Schwann cell proliferation 2/803 11/18722 0.0781884050362737 0.237036068588221 SKI/CERS2 2 GO:0021889 olfactory bulb interneuron differentiation 2/803 11/18722 0.0781884050362737 0.237036068588221 SLIT2/ROBO1 2 GO:0030656 regulation of vitamin metabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 SNAI2/RDH10 2 GO:0032000 positive regulation of fatty acid beta-oxidation 2/803 11/18722 0.0781884050362737 0.237036068588221 IRS1/TWIST1 2 GO:0032341 aldosterone metabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP5/DKK3 2 GO:0032351 negative regulation of hormone metabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP5/DKK3 2 GO:0033690 positive regulation of osteoblast proliferation 2/803 11/18722 0.0781884050362737 0.237036068588221 CTHRC1/ABL1 2 GO:0034975 protein folding in endoplasmic reticulum 2/803 11/18722 0.0781884050362737 0.237036068588221 HSP90B1/CANX 2 GO:0042789 mRNA transcription by RNA polymerase II 2/803 11/18722 0.0781884050362737 0.237036068588221 FLNA/STAT3 2 GO:0043589 skin morphogenesis 2/803 11/18722 0.0781884050362737 0.237036068588221 COL1A1/COL1A2 2 GO:0045657 positive regulation of monocyte differentiation 2/803 11/18722 0.0781884050362737 0.237036068588221 CSF1/ZFP36L1 2 GO:0045793 positive regulation of cell size 2/803 11/18722 0.0781884050362737 0.237036068588221 RB1CC1/TMEM123 2 GO:0046349 amino sugar biosynthetic process 2/803 11/18722 0.0781884050362737 0.237036068588221 PGM3/UAP1 2 GO:0046710 GDP metabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 CASK/MAGI3 2 GO:0048635 negative regulation of muscle organ development 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP4/TWIST1 2 GO:0048680 positive regulation of axon regeneration 2/803 11/18722 0.0781884050362737 0.237036068588221 FLNA/LRP1 2 GO:0051081 nuclear membrane disassembly 2/803 11/18722 0.0781884050362737 0.237036068588221 PRKCA/LPIN1 2 GO:0060379 cardiac muscle cell myoblast differentiation 2/803 11/18722 0.0781884050362737 0.237036068588221 TBX2/PRICKLE1 2 GO:0060433 bronchus development 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP4/TGFBR2 2 GO:0060900 embryonic camera-type eye formation 2/803 11/18722 0.0781884050362737 0.237036068588221 TWIST1/FRS2 2 GO:0071492 cellular response to UV-A 2/803 11/18722 0.0781884050362737 0.237036068588221 MMP2/TIMP1 2 GO:0072110 glomerular mesangial cell proliferation 2/803 11/18722 0.0781884050362737 0.237036068588221 PDGFRB/BMP4 2 GO:0072205 metanephric collecting duct development 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP4/PKD1 2 GO:0072697 protein localization to cell cortex 2/803 11/18722 0.0781884050362737 0.237036068588221 EPB41L2/GNAI1 2 GO:0090205 positive regulation of cholesterol metabolic process 2/803 11/18722 0.0781884050362737 0.237036068588221 CES1/PRKAA1 2 GO:0097048 dendritic cell apoptotic process 2/803 11/18722 0.0781884050362737 0.237036068588221 GAS6/AXL 2 GO:0097090 presynaptic membrane organization 2/803 11/18722 0.0781884050362737 0.237036068588221 PTPRD/PTEN 2 GO:1902033 regulation of hematopoietic stem cell proliferation 2/803 11/18722 0.0781884050362737 0.237036068588221 KITLG/N4BP2L2 2 GO:1904181 positive regulation of membrane depolarization 2/803 11/18722 0.0781884050362737 0.237036068588221 DCN/TSPO 2 GO:1904321 response to forskolin 2/803 11/18722 0.0781884050362737 0.237036068588221 ADCY3/GNAI1 2 GO:1904322 cellular response to forskolin 2/803 11/18722 0.0781884050362737 0.237036068588221 ADCY3/GNAI1 2 GO:1905050 positive regulation of metallopeptidase activity 2/803 11/18722 0.0781884050362737 0.237036068588221 ANTXR1/STAT3 2 GO:1905668 positive regulation of protein localization to endosome 2/803 11/18722 0.0781884050362737 0.237036068588221 ROCK2/MSN 2 GO:2000392 regulation of lamellipodium morphogenesis 2/803 11/18722 0.0781884050362737 0.237036068588221 PDPN/ENPP2 2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 2/803 11/18722 0.0781884050362737 0.237036068588221 PRKAR1A/PKIG 2 GO:2000668 regulation of dendritic cell apoptotic process 2/803 11/18722 0.0781884050362737 0.237036068588221 GAS6/AXL 2 GO:2000826 regulation of heart morphogenesis 2/803 11/18722 0.0781884050362737 0.237036068588221 BMP4/ROBO1 2 GO:0006892 post-Golgi vesicle-mediated transport 8/803 104/18722 0.0783237396353279 0.237036068588221 STXBP6/MYO1B/SPTBN1/MON2/PREPL/SORT1/MACF1/GOLGA4 8 GO:0048661 positive regulation of smooth muscle cell proliferation 8/803 104/18722 0.0783237396353279 0.237036068588221 MMP2/IGFBP5/PDGFRB/BMP4/THBS1/GJA1/ADAMTS1/TGFBR2 8 GO:0000578 embryonic axis specification 4/803 38/18722 0.078489079269786 0.237036068588221 BASP1/PCSK6/FRS2/EPB41L5 4 GO:0001825 blastocyst formation 4/803 38/18722 0.078489079269786 0.237036068588221 YAP1/SKIL/RTN4/SP3 4 GO:0002478 antigen processing and presentation of exogenous peptide antigen 4/803 38/18722 0.078489079269786 0.237036068588221 HLA-A/B2M/HLA-F/LNPEP 4 GO:0010742 macrophage derived foam cell differentiation 4/803 38/18722 0.078489079269786 0.237036068588221 PLA2G2A/CSF1/CD36/ABCA5 4 GO:0030279 negative regulation of ossification 4/803 38/18722 0.078489079269786 0.237036068588221 ENPP1/ECM1/MDK/LTBP3 4 GO:0035886 vascular associated smooth muscle cell differentiation 4/803 38/18722 0.078489079269786 0.237036068588221 EFEMP2/GATA6/SGCB/ENG 4 GO:0046633 alpha-beta T cell proliferation 4/803 38/18722 0.078489079269786 0.237036068588221 TWSG1/HLA-A/CD81/TGFBR2 4 GO:0071398 cellular response to fatty acid 4/803 38/18722 0.078489079269786 0.237036068588221 CLDN1/IRS1/PDK4/PID1 4 GO:0090077 foam cell differentiation 4/803 38/18722 0.078489079269786 0.237036068588221 PLA2G2A/CSF1/CD36/ABCA5 4 GO:1901186 positive regulation of ERBB signaling pathway 4/803 38/18722 0.078489079269786 0.237036068588221 PLAUR/RTN4/CCDC88A/SOS1 4 GO:1903580 positive regulation of ATP metabolic process 4/803 38/18722 0.078489079269786 0.237036068588221 NUPR1/PID1/STAT3/PRKAA1 4 GO:0008654 phospholipid biosynthetic process 16/803 253/18722 0.0789052938500642 0.238141121128237 ABCA8/PTEN/SERINC1/PIK3R1/SOCS2/CISH/LPGAT1/AGPAT2/LPCAT2/SOCS3/LPIN1/CAPN2/SGMS1/SERINC5/ATM/IPMK 16 GO:0050768 negative regulation of neurogenesis 10/803 140/18722 0.0789505160900472 0.238141121128237 THY1/TMEM98/SEMA3B/PTEN/B2M/TSPO/SEMA6D/RTN4/SKI/CERS2 10 GO:0098739 import across plasma membrane 12/803 177/18722 0.079189840782481 0.238718588960974 CD36/THBS1/SLC2A10/ATP1B1/SLC9A9/SLC39A6/PRNP/ITGB1/SLC5A3/WNK1/SLC39A4/SLC8A1 12 GO:0007029 endoplasmic reticulum organization 7/803 87/18722 0.0796588923057898 0.239987454402821 TRAM1/SEC61A1/TRAM2/SEC31A/RTN4/ATL3/ESYT2 7 GO:0045862 positive regulation of proteolysis 22/803 372/18722 0.0806143984042108 0.241771283956273 F3/ANTXR1/SPON1/PCOLCE/APOE/UACA/PRICKLE1/PCOLCE2/PTEN/ROBO1/CLU/ROCK2/EGLN3/NUPR1/DLC1/FBLN1/DAPK1/DAB2/STAT3/IFI16/GSN/HECTD1 22 GO:0035966 response to topologically incorrect protein 11/803 159/18722 0.0807707633948734 0.241771283956273 CREB3L1/THBS1/HSPA2/TRAM1/CLU/SERPINH1/PIK3R1/AMFR/CREBRF/MBTPS1/HSPB1 11 GO:0051170 import into nucleus 11/803 159/18722 0.0807707633948734 0.241771283956273 APOD/CD36/BMP4/ANGPT1/PRICKLE1/FLNA/RAB23/PIK3R1/TXNIP/PKIG/STAT3 11 GO:1903169 regulation of calcium ion transmembrane transport 11/803 159/18722 0.0807707633948734 0.241771283956273 THY1/BIN1/HSPA2/ATP1B1/CAMK2D/PKD2/PRNP/AHNAK/SESTD1/ABL1/SLC8A1 11 GO:0006968 cellular defense response 5/803 54/18722 0.0809569147636115 0.241771283956273 RAB23/LSP1/ITGB1/LGALS3BP/ZNF148 5 GO:0031050 dsRNA processing 5/803 54/18722 0.0809569147636115 0.241771283956273 BMP4/NCOR2/AGO3/STAT3/PUM2 5 GO:0070918 production of small RNA involved in gene silencing by RNA 5/803 54/18722 0.0809569147636115 0.241771283956273 BMP4/NCOR2/AGO3/STAT3/PUM2 5 GO:0001702 gastrulation with mouth forming second 3/803 24/18722 0.0815602285628663 0.241771283956273 ACVR2A/UGDH/FRS2 3 GO:0021801 cerebral cortex radial glia-guided migration 3/803 24/18722 0.0815602285628663 0.241771283956273 LAMB1/RTN4/ZMIZ1 3 GO:0022030 telencephalon glial cell migration 3/803 24/18722 0.0815602285628663 0.241771283956273 LAMB1/RTN4/ZMIZ1 3 GO:0031639 plasminogen activation 3/803 24/18722 0.0815602285628663 0.241771283956273 SERPINE2/THBS1/PLAU 3 GO:0033032 regulation of myeloid cell apoptotic process 3/803 24/18722 0.0815602285628663 0.241771283956273 KITLG/THRA/PTEN 3 GO:0035458 cellular response to interferon-beta 3/803 24/18722 0.0815602285628663 0.241771283956273 IFITM2/CAPN2/IFI16 3 GO:0044062 regulation of excretion 3/803 24/18722 0.0815602285628663 0.241771283956273 STC1/SPX/EDNRB 3 GO:0044321 response to leptin 3/803 24/18722 0.0815602285628663 0.241771283956273 PTEN/PID1/STAT3 3 GO:0048641 regulation of skeletal muscle tissue development 3/803 24/18722 0.0815602285628663 0.241771283956273 IGF2/TWIST1/PRKAA1 3 GO:0050820 positive regulation of coagulation 3/803 24/18722 0.0815602285628663 0.241771283956273 F3/CD36/THBS1 3 GO:0060149 negative regulation of posttranscriptional gene silencing 3/803 24/18722 0.0815602285628663 0.241771283956273 KCNQ1OT1/NCOR2/STAT3 3 GO:0060561 apoptotic process involved in morphogenesis 3/803 24/18722 0.0815602285628663 0.241771283956273 HAND2/CRYAB/TNFRSF1A 3 GO:0060967 negative regulation of gene silencing by RNA 3/803 24/18722 0.0815602285628663 0.241771283956273 KCNQ1OT1/NCOR2/STAT3 3 GO:0071378 cellular response to growth hormone stimulus 3/803 24/18722 0.0815602285628663 0.241771283956273 PIK3R1/SOCS2/STAT3 3 GO:0071577 zinc ion transmembrane transport 3/803 24/18722 0.0815602285628663 0.241771283956273 SLC39A13/SLC39A6/SLC39A4 3 GO:0120255 olefinic compound biosynthetic process 3/803 24/18722 0.0815602285628663 0.241771283956273 BMP5/DKK3/H6PD 3 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 3/803 24/18722 0.0815602285628663 0.241771283956273 CD36/SLC5A3/FOXO3 3 GO:2000209 regulation of anoikis 3/803 24/18722 0.0815602285628663 0.241771283956273 SNAI2/PDK4/ITGB1 3 GO:2000353 positive regulation of endothelial cell apoptotic process 3/803 24/18722 0.0815602285628663 0.241771283956273 CD248/THBS1/FOXO3 3 GO:2000679 positive regulation of transcription regulatory region DNA binding 3/803 24/18722 0.0815602285628663 0.241771283956273 HAND2/TWIST1/KLF4 3 GO:0045930 negative regulation of mitotic cell cycle 15/803 235/18722 0.0817311563023227 0.242121747887163 FHL1/BMP4/KANK2/GAS1/PTEN/GPNMB/PKD2/ZFP36L2/ZFP36L1/KLF4/ABL1/TAOK1/TIMP2/ATM/USP47 15 GO:0000041 transition metal ion transport 8/803 105/18722 0.0817755763020423 0.242121747887163 CYBRD1/SLC39A13/STEAP4/SLC39A6/B2M/SLC40A1/SLC39A4/CLTC 8 GO:1903038 negative regulation of leukocyte cell-cell adhesion 10/803 141/18722 0.0818962528274052 0.242335143381271 BMP4/TWSG1/GPNMB/MDK/PRNP/PAG1/KLF4/PRKAR1A/WNK1/NDFIP1 10 GO:0050870 positive regulation of T cell activation 14/803 216/18722 0.0821426843678196 0.242920180461417 IGFBP2/VCAM1/THY1/IL6ST/IGF2/LGALS1/HLA-A/CD81/MDK/DPP4/B2M/TGFBR2/MAP3K8/ZMIZ1 14 GO:0043271 negative regulation of ion transport 11/803 160/18722 0.0835639031804999 0.24683034434714 STC1/SERPINE2/BIN1/PTEN/CAMK2D/PKD2/PXK/TWIST1/SESTD1/PLA2R1/WNK1 11 GO:0090316 positive regulation of intracellular protein transport 11/803 160/18722 0.0835639031804999 0.24683034434714 GAS6/FLNA/CD81/PIK3R1/PRNP/NPEPPS/SAR1A/STOM/PRKAA1/MYO1C/CEP290 11 GO:0050795 regulation of behavior 6/803 71/18722 0.0836881628433658 0.247051024237432 PTGDS/APOE/GJA1/MDK/STAT3/ZFHX3 6 GO:0062012 regulation of small molecule metabolic process 20/803 334/18722 0.0840191879825203 0.247881462296359 ENPP1/BMP5/NNMT/DKK3/SNAI2/APOE/CES1/IGF2/RDH10/IRS1/PDK4/NCOR2/LPGAT1/TWIST1/NUPR1/H6PD/PID1/STAT3/PRKAA1/MBTPS1 20 GO:0007416 synapse assembly 12/803 179/18722 0.0844382884871625 0.248822303146289 FLRT3/PTPRD/MAP1B/AMIGO2/EFNB2/PTEN/NRCAM/PDLIM5/PLXNB2/NPTN/CLSTN1/FARP1 12 GO:0001914 regulation of T cell mediated cytotoxicity 4/803 39/18722 0.0846375102559378 0.248822303146289 HLA-B/HLA-A/B2M/HLA-F 4 GO:0002701 negative regulation of production of molecular mediator of immune response 4/803 39/18722 0.0846375102559378 0.248822303146289 ANGPT1/BST2/HLA-F/NDFIP1 4 GO:0016572 histone phosphorylation 4/803 39/18722 0.0846375102559378 0.248822303146289 PRKCA/TWIST1/PRKAA1/ATM 4 GO:0046326 positive regulation of glucose import 4/803 39/18722 0.0846375102559378 0.248822303146289 GPC3/IRS1/PIK3R1/RHOQ 4 GO:0090224 regulation of spindle organization 4/803 39/18722 0.0846375102559378 0.248822303146289 PKD1/GNAI1/MAP9/CLTC 4 GO:0019882 antigen processing and presentation 8/803 106/18722 0.0853160404558216 0.250669285629185 THBS1/HLA-B/HLA-A/HLA-C/EXT1/B2M/HLA-F/LNPEP 8 GO:0010508 positive regulation of autophagy 9/803 124/18722 0.0856034772968974 0.251365687751667 DCN/MTDH/SESN3/TPCN1/DAPK1/FOXO3/TMEM59/PRKAA1/BNIP3L 9 GO:0003229 ventricular cardiac muscle tissue development 5/803 55/18722 0.0860769179757438 0.25245853707474 COL11A1/HEG1/TGFBR3/ENG/TPM1 5 GO:0044091 membrane biogenesis 5/803 55/18722 0.0860769179757438 0.25245853707474 PTPRD/SPTBN1/PTEN/SERINC1/STX2 5 GO:0042445 hormone metabolic process 14/803 218/18722 0.0869777890215375 0.25480097300904 BMP5/PDGFRA/SLC16A10/RBP1/HSD17B2/CRABP1/DKK3/CTSK/ECE1/RDH10/TSPO/H6PD/PCSK6/ALDH9A1 14 GO:0050803 regulation of synapse structure or activity 14/803 218/18722 0.0869777890215375 0.25480097300904 FLRT3/PTPRD/SPARC/AMIGO2/APOE/PTEN/PDLIM5/NRP2/PRNP/ABI2/ABL1/CLSTN1/ITSN1/FARP1 14 GO:0050890 cognition 18/803 296/18722 0.0872043572156531 0.255314694701847 CCND2/ADCY3/APOE/THRA/MEIS2/SERPINF1/PTEN/MDK/B2M/PRNP/PLCB1/ITGB1/NPTN/AMFR/EIF4EBP2/VLDLR/PJA2/ATXN1 18 GO:0062013 positive regulation of small molecule metabolic process 10/803 143/18722 0.0879874118254319 0.256725840307931 NNMT/CES1/IGF2/RDH10/IRS1/LPGAT1/TWIST1/PID1/STAT3/PRKAA1 10 GO:0043903 regulation of biological process involved in symbiotic interaction 6/803 72/18722 0.0881697705272027 0.256725840307931 IFITM2/IFITM3/LGALS1/IFITM1/FUCA2/GSN 6 GO:0051259 protein complex oligomerization 15/803 238/18722 0.0886970783575753 0.256725840307931 COL1A2/KCTD12/STEAP4/CLDN1/PKD1/GLS/UGDH/B2M/PKD2/PRNP/TIFA/KCTD2/ALDH9A1/TMEM120A/ATL3 15 GO:0006658 phosphatidylserine metabolic process 3/803 25/18722 0.0898566284830061 0.256725840307931 SERINC1/SERINC3/SERINC5 3 GO:0010560 positive regulation of glycoprotein biosynthetic process 3/803 25/18722 0.0898566284830061 0.256725840307931 SLC2A10/RAMP1/PLCB1 3 GO:0015012 heparan sulfate proteoglycan biosynthetic process 3/803 25/18722 0.0898566284830061 0.256725840307931 CSGALNACT1/EXT1/UGDH 3 GO:0032104 regulation of response to extracellular stimulus 3/803 25/18722 0.0898566284830061 0.256725840307931 SPX/SNAI2/KANK2 3 GO:0032107 regulation of response to nutrient levels 3/803 25/18722 0.0898566284830061 0.256725840307931 SPX/SNAI2/KANK2 3 GO:0032331 negative regulation of chondrocyte differentiation 3/803 25/18722 0.0898566284830061 0.256725840307931 SNAI2/BMP4/LTBP3 3 GO:0032925 regulation of activin receptor signaling pathway 3/803 25/18722 0.0898566284830061 0.256725840307931 FST/ACVR2A/SKI 3 GO:0033622 integrin activation 3/803 25/18722 0.0898566284830061 0.256725840307931 COL16A1/FBLIM1/PIEZO1 3 GO:0045109 intermediate filament organization 3/803 25/18722 0.0898566284830061 0.256725840307931 DES/VIM/PLEC 3 GO:0060740 prostate gland epithelium morphogenesis 3/803 25/18722 0.0898566284830061 0.256725840307931 HOXA13/BMP4/FRS2 3 GO:0062009 secondary palate development 3/803 25/18722 0.0898566284830061 0.256725840307931 TSHZ1/TGFBR3/TGFBR2 3 GO:0071450 cellular response to oxygen radical 3/803 25/18722 0.0898566284830061 0.256725840307931 FBLN5/CD36/SOD3 3 GO:0071451 cellular response to superoxide 3/803 25/18722 0.0898566284830061 0.256725840307931 FBLN5/CD36/SOD3 3 GO:1901798 positive regulation of signal transduction by p53 class mediator 3/803 25/18722 0.0898566284830061 0.256725840307931 SPRED1/PLA2R1/ATM 3 GO:1902993 positive regulation of amyloid precursor protein catabolic process 3/803 25/18722 0.0898566284830061 0.256725840307931 SPON1/CLU/ROCK2 3 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 3/803 25/18722 0.0898566284830061 0.256725840307931 BMP4/NCOR2/STAT3 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/803 25/18722 0.0898566284830061 0.256725840307931 IGFBP5/ADAMTS1/LRP1 3 GO:0097696 receptor signaling pathway via STAT 12/803 181/18722 0.0898990383770799 0.256725840307931 PTPRD/PRLR/IL6ST/PKD1/PKD2/SOCS2/SOCS3/TNFRSF1A/STAT3/FER/IFNAR1/JAK1 12 GO:0022898 regulation of transmembrane transporter activity 17/803 278/18722 0.09087232187391 0.256725840307931 FHL1/FXYD1/GJA1/HSPA2/ATP1B1/PTEN/CAMK2D/PKD2/PRNP/AHNAK/TWIST1/ITGB1/IFNGR2/WNK1/DAPK1/STOM/ACTN4 17 GO:0010863 positive regulation of phospholipase C activity 4/803 40/18722 0.0910134537019959 0.256725840307931 PDGFRA/PDGFRB/LPAR1/FGFR1 4 GO:0043001 Golgi to plasma membrane protein transport 4/803 40/18722 0.0910134537019959 0.256725840307931 SPTBN1/PREPL/MACF1/GOLGA4 4 GO:1901998 toxin transport 4/803 40/18722 0.0910134537019959 0.256725840307931 ANTXR1/SLC22A3/ANTXR2/LRP6 4 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 4/803 40/18722 0.0910134537019959 0.256725840307931 MDK/NFAT5/KLF4/ZDHHC21 4 GO:2000142 regulation of DNA-templated transcription, initiation 4/803 40/18722 0.0910134537019959 0.256725840307931 THRA/TWIST1/SETX/MED13 4 GO:0072593 reactive oxygen species metabolic process 15/803 239/18722 0.0911002448893545 0.256725840307931 FBLN5/PDGFRB/CD36/THBS1/CRYAB/SOD3/PDK4/SH3PXD2A/TSPO/TGFBR2/SLC5A3/PID1/PLA2R1/FOXO3/STAT3 15 GO:1903039 positive regulation of leukocyte cell-cell adhesion 15/803 239/18722 0.0911002448893545 0.256725840307931 IGFBP2/VCAM1/THY1/IL6ST/IGF2/LGALS1/HLA-A/CD81/MDK/DPP4/B2M/NFAT5/TGFBR2/MAP3K8/ZMIZ1 15 GO:0002664 regulation of T cell tolerance induction 2/803 12/18722 0.0912391073055863 0.256725840307931 HLA-B/TGFBR2 2 GO:0003207 cardiac chamber formation 2/803 12/18722 0.0912391073055863 0.256725840307931 HAND2/TBX2 2 GO:0006563 L-serine metabolic process 2/803 12/18722 0.0912391073055863 0.256725840307931 SERINC3/SERINC5 2 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/803 12/18722 0.0912391073055863 0.256725840307931 SEC61A1/SEC62 2 GO:0007320 insemination 2/803 12/18722 0.0912391073055863 0.256725840307931 SERPINE2/ACVR2A 2 GO:0007614 short-term memory 2/803 12/18722 0.0912391073055863 0.256725840307931 SERPINF1/MDK 2 GO:0008212 mineralocorticoid metabolic process 2/803 12/18722 0.0912391073055863 0.256725840307931 BMP5/DKK3 2 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 2/803 12/18722 0.0912391073055863 0.256725840307931 APOD/LRP1 2 GO:0014831 gastro-intestinal system smooth muscle contraction 2/803 12/18722 0.0912391073055863 0.256725840307931 SPX/SULF2 2 GO:0014889 muscle atrophy 2/803 12/18722 0.0912391073055863 0.256725840307931 FOXO3/GSN 2 GO:0030397 membrane disassembly 2/803 12/18722 0.0912391073055863 0.256725840307931 PRKCA/LPIN1 2 GO:0031953 negative regulation of protein autophosphorylation 2/803 12/18722 0.0912391073055863 0.256725840307931 ENPP1/ENG 2 GO:0032780 negative regulation of ATPase activity 2/803 12/18722 0.0912391073055863 0.256725840307931 CNN3/PXK 2 GO:0032782 bile acid secretion 2/803 12/18722 0.0912391073055863 0.256725840307931 CES1/PRKAA1 2 GO:0032823 regulation of natural killer cell differentiation 2/803 12/18722 0.0912391073055863 0.256725840307931 GAS6/AXL 2 GO:0032926 negative regulation of activin receptor signaling pathway 2/803 12/18722 0.0912391073055863 0.256725840307931 FST/SKI 2 GO:0034333 adherens junction assembly 2/803 12/18722 0.0912391073055863 0.256725840307931 VCL/HIPK1 2 GO:0038180 nerve growth factor signaling pathway 2/803 12/18722 0.0912391073055863 0.256725840307931 SORT1/KIDINS220 2 GO:0044650 adhesion of symbiont to host cell 2/803 12/18722 0.0912391073055863 0.256725840307931 GAS6/CD81 2 GO:0045916 negative regulation of complement activation 2/803 12/18722 0.0912391073055863 0.256725840307931 SERPING1/A2M 2 GO:0051549 positive regulation of keratinocyte migration 2/803 12/18722 0.0912391073055863 0.256725840307931 FGF7/MAP4K4 2 GO:0060788 ectodermal placode formation 2/803 12/18722 0.0912391073055863 0.256725840307931 TBX2/FRS2 2 GO:0060907 positive regulation of macrophage cytokine production 2/803 12/18722 0.0912391073055863 0.256725840307931 SPON2/CD36 2 GO:0061430 bone trabecula morphogenesis 2/803 12/18722 0.0912391073055863 0.256725840307931 COL1A1/MMP2 2 GO:0061517 macrophage proliferation 2/803 12/18722 0.0912391073055863 0.256725840307931 CSF1/CLU 2 GO:0071257 cellular response to electrical stimulus 2/803 12/18722 0.0912391073055863 0.256725840307931 PALM/PTEN 2 GO:0071635 negative regulation of transforming growth factor beta production 2/803 12/18722 0.0912391073055863 0.256725840307931 GATA6/LAPTM4B 2 GO:0071697 ectodermal placode morphogenesis 2/803 12/18722 0.0912391073055863 0.256725840307931 TBX2/FRS2 2 GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/803 12/18722 0.0912391073055863 0.256725840307931 PROM1/YAP1 2 GO:0090177 establishment of planar polarity involved in neural tube closure 2/803 12/18722 0.0912391073055863 0.256725840307931 CTHRC1/PTK7 2 GO:0090557 establishment of endothelial intestinal barrier 2/803 12/18722 0.0912391073055863 0.256725840307931 CLDN1/TJP1 2 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/803 12/18722 0.0912391073055863 0.256725840307931 HGF/FOXO3 2 GO:1902950 regulation of dendritic spine maintenance 2/803 12/18722 0.0912391073055863 0.256725840307931 APOE/PRNP 2 GO:1903909 regulation of receptor clustering 2/803 12/18722 0.0912391073055863 0.256725840307931 CD81/GSN 2 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 2/803 12/18722 0.0912391073055863 0.256725840307931 WNT2/LRP6 2 GO:1905245 regulation of aspartic-type peptidase activity 2/803 12/18722 0.0912391073055863 0.256725840307931 BIN1/ROCK2 2 GO:1905666 regulation of protein localization to endosome 2/803 12/18722 0.0912391073055863 0.256725840307931 ROCK2/MSN 2 GO:2000727 positive regulation of cardiac muscle cell differentiation 2/803 12/18722 0.0912391073055863 0.256725840307931 BMP4/EFNB2 2 GO:2001204 regulation of osteoclast development 2/803 12/18722 0.0912391073055863 0.256725840307931 NOTCH2/FBN1 2 GO:2001214 positive regulation of vasculogenesis 2/803 12/18722 0.0912391073055863 0.256725840307931 RRAS/RIN2 2 GO:0022029 telencephalon cell migration 5/803 56/18722 0.0913624470754003 0.256783067146531 SLIT2/ROBO1/LAMB1/RTN4/ZMIZ1 5 GO:0043388 positive regulation of DNA binding 5/803 56/18722 0.0913624470754003 0.256783067146531 HAND2/TWIST1/KLF4/PLAUR/SKI 5 GO:0070664 negative regulation of leukocyte proliferation 7/803 90/18722 0.0915553960610481 0.257035588265983 BMP4/TWSG1/GPNMB/PRNP/PRKAR1A/ATM/NDFIP1 7 GO:0099175 regulation of postsynapse organization 7/803 90/18722 0.0915553960610481 0.257035588265983 PTPRD/APOE/PTEN/PDLIM5/NRP2/PRNP/ABI2 7 GO:0045927 positive regulation of growth 16/803 259/18722 0.0922953762153697 0.258828815124449 WNT2/CSF1/TBX2/GATA6/MAP1B/IGF2/TGFBR3/BASP1/LRP1/PLCB1/TGFBR2/YAP1/BMPR2/MACF1/GOLGA4/USP47 16 GO:0072331 signal transduction by p53 class mediator 11/803 163/18722 0.092297960948911 0.258828815124449 SNAI2/TWIST1/NDRG1/NUPR1/SPRED1/PLA2R1/ATRX/FOXO3/HIPK1/IFI16/ATM 11 GO:0032874 positive regulation of stress-activated MAPK cascade 9/803 126/18722 0.0923507856378414 0.258831375598807 HAND2/GDF6/BMP4/MFHAS1/PLCB1/TAOK1/PJA2/RB1CC1/LTBR 9 GO:1901990 regulation of mitotic cell cycle phase transition 18/803 299/18722 0.0936467732993534 0.262316186331784 CCND2/FHL1/KANK2/ADAMTS1/HSPA2/PTEN/GPNMB/PKD1/PKD2/PLCB1/ZFP36L2/ZFP36L1/CDC25B/KLF4/TAOK1/KMT2E/ATM/USP47 18 GO:0007204 positive regulation of cytosolic calcium ion concentration 19/803 319/18722 0.0939144693365258 0.262770787941592 PDGFRA/THY1/PTGFR/CD36/EDNRB/LPAR1/GJA1/CMKLR1/PTGER2/CAMK2D/PKD1/LRP1/PKD2/LRP6/PRNP/ABL1/TPCN1/NPTN/SLC8A1 19 GO:0008202 steroid metabolic process 19/803 319/18722 0.0939144693365258 0.262770787941592 BMP5/PDGFRA/HSD17B2/DKK3/SNAI2/APOE/PRLR/CES1/APOL1/TSPO/H6PD/CYB5R3/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/EBPL/MBTPS1 19 GO:0051961 negative regulation of nervous system development 10/803 145/18722 0.0943447249471273 0.263826583615466 THY1/TMEM98/SEMA3B/PTEN/B2M/TSPO/SEMA6D/RTN4/SKI/CERS2 10 GO:0071219 cellular response to molecule of bacterial origin 14/803 221/18722 0.0945611914895272 0.264283688770618 SPON2/CD36/EDNRB/PLSCR4/PRKCA/VIM/TFPI/AXL/MTDH/TSPO/ABL1/CAPN2/SGMS1/LITAF 14 GO:0009913 epidermal cell differentiation 13/803 202/18722 0.0952710197318771 0.26611837780568 PITX2/GATA6/BMP4/PPL/PALLD/ROCK2/YAP1/TXNIP/ZFP36L1/KLF4/PLEC/FOSL2/JAG1 13 GO:0050792 regulation of viral process 11/803 164/18722 0.0953275401029209 0.266127164027527 IFITM2/IFITM3/LGALS1/IFITM1/AXL/BST2/RSF1/STOM/FAM111A/IFI16/GSN 11 GO:0051224 negative regulation of protein transport 9/803 127/18722 0.0958381561137467 0.267402935860739 APOD/CD36/APOE/ANGPT1/IRS1/RAB23/PKIG/MAP4K4/NDFIP1 9 GO:0002456 T cell mediated immunity 8/803 109/18722 0.0964670281301284 0.26900704824207 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F/JAG1/BTN3A2 8 GO:0006695 cholesterol biosynthetic process 5/803 57/18722 0.0968112090174639 0.269364223304171 APOE/CES1/CYB5R3/PRKAA1/MBTPS1 5 GO:0033619 membrane protein proteolysis 5/803 57/18722 0.0968112090174639 0.269364223304171 APOE/TIMP1/TIMP3/TIMP2/MBTPS1 5 GO:0060760 positive regulation of response to cytokine stimulus 5/803 57/18722 0.0968112090174639 0.269364223304171 CSF1/GAS6/IL1R1/AXL/AGPAT2 5 GO:1902653 secondary alcohol biosynthetic process 5/803 57/18722 0.0968112090174639 0.269364223304171 APOE/CES1/CYB5R3/PRKAA1/MBTPS1 5 GO:0051881 regulation of mitochondrial membrane potential 6/803 74/18722 0.0975177320477651 0.270534335914097 DCN/TSPO/ABL1/PID1/BNIP3L/GCLM 6 GO:0048634 regulation of muscle organ development 4/803 41/18722 0.0976115664479465 0.270534335914097 BMP4/IGF2/TWIST1/PRKAA1 4 GO:0051693 actin filament capping 4/803 41/18722 0.0976115664479465 0.270534335914097 LMOD1/SPTBN1/EPS8/GSN 4 GO:0071470 cellular response to osmotic stress 4/803 41/18722 0.0976115664479465 0.270534335914097 MYLK/PKD2/TSPO/ZFP36L1 4 GO:0071634 regulation of transforming growth factor beta production 4/803 41/18722 0.0976115664479465 0.270534335914097 LUM/GATA6/THBS1/LAPTM4B 4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 4/803 41/18722 0.0976115664479465 0.270534335914097 MYADM/FLNA/MDK/ABL1 4 GO:1902622 regulation of neutrophil migration 4/803 41/18722 0.0976115664479465 0.270534335914097 SLIT2/IL1R1/MDK/DPP4 4 GO:0070997 neuron death 21/803 361/18722 0.0978942357279281 0.271167032966361 CSF1/ITGA1/APOE/ANGPT1/EFNB2/SERPINF1/GPNMB/MDK/LRP1/AXL/CLU/EGLN3/PRNP/NUPR1/ABL1/AP2B1/HLA-F/CAPN2/FOXO3/STAT3/GCLM 21 GO:0006643 membrane lipid metabolic process 13/803 203/18722 0.0980305794289362 0.271393930612258 ENPP2/ELOVL2/ABCA8/PLPP1/PLPP3/SERINC1/SERINC3/SGMS1/PRKAA1/SERINC5/CERS2/CERS6/FADS3 13 GO:0072594 establishment of protein localization to organelle 24/803 422/18722 0.0982168083553744 0.271756599737776 APOD/CD36/BMP4/ANGPT1/MAN1A1/PRICKLE1/FLNA/RAB23/TRAM1/CLU/PIK3R1/TSPO/SEC61A1/TRAM2/TXNIP/SCARB2/SEC62/PKIG/NPEPPS/STAT3/PRKAA1/BNIP3L/SORT1/TERF1 24 GO:0001556 oocyte maturation 3/803 26/18722 0.0984886032342882 0.271756599737776 PDE3A/CDC25B/FOXO3 3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 3/803 26/18722 0.0984886032342882 0.271756599737776 TRAM1/SEC61A1/TRAM2 3 GO:0046697 decidualization 3/803 26/18722 0.0984886032342882 0.271756599737776 STC1/GJA1/ASH1L 3 GO:0048668 collateral sprouting 3/803 26/18722 0.0984886032342882 0.271756599737776 LRP1/NIN/ABL1 3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 3/803 26/18722 0.0984886032342882 0.271756599737776 BMP4/NCOR2/STAT3 3 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 9/803 128/18722 0.0994010514406649 0.274122589869002 HAND2/GDF6/BMP4/MFHAS1/PLCB1/TAOK1/PJA2/RB1CC1/LTBR 9 GO:0048525 negative regulation of viral process 7/803 92/18722 0.100009351288786 0.275647664746205 IFITM2/IFITM3/IFITM1/BST2/FAM111A/IFI16/GSN 7 GO:1905954 positive regulation of lipid localization 8/803 110/18722 0.100359450075635 0.276459788992881 ABCA8/CD36/APOE/CES1/LRP1/PLTP/PLA2R1/ABCA5 8 GO:1902652 secondary alcohol metabolic process 10/803 147/18722 0.100967483186866 0.277981154704424 APOE/CES1/APOL1/CYB5R3/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/MBTPS1 10 GO:0044772 mitotic cell cycle phase transition 24/803 424/18722 0.102064866417516 0.280847364215085 CCND2/FHL1/KANK2/ADAMTS1/CCNG2/HSPA2/PTEN/CDK18/GPNMB/PKD1/PKD2/EIF4EBP1/PLCB1/ZFP36L2/ZFP36L1/ITGB1/EPS8/CDC25B/KLF4/TAOK1/BACH1/KMT2E/ATM/USP47 24 GO:0043627 response to estrogen 6/803 75/18722 0.102381603560011 0.280896269290209 IGFBP2/PDGFRB/GATA6/TGFBR2/GSTM3/SERPINB9 6 GO:0061333 renal tubule morphogenesis 6/803 75/18722 0.102381603560011 0.280896269290209 TCF21/BMP4/GPC3/COL4A1/PKD1/PKD2 6 GO:0002763 positive regulation of myeloid leukocyte differentiation 5/803 58/18722 0.102420661365744 0.280896269290209 CSF1/KITLG/PRKCA/ZFP36L1/NOTCH2 5 GO:0006826 iron ion transport 5/803 58/18722 0.102420661365744 0.280896269290209 CYBRD1/STEAP4/B2M/SLC40A1/CLTC 5 GO:0034340 response to type I interferon 5/803 58/18722 0.102420661365744 0.280896269290209 IFITM2/IFITM3/IFITM1/IFNAR1/JAK1 5 GO:0086065 cell communication involved in cardiac conduction 5/803 58/18722 0.102420661365744 0.280896269290209 GJA1/FLNA/ATP1B1/CAMK2D/SLC8A1 5 GO:0072503 cellular divalent inorganic cation homeostasis 27/803 486/18722 0.102810833796633 0.281811334420017 PDGFRA/STC1/THY1/PTGFR/CD36/EDNRB/LPAR1/APOE/GJA1/CMKLR1/PTGER2/SLC39A13/ATP1B1/CAMK2D/PKD1/LRP1/SLC39A6/PKD2/LRP6/PRNP/ABL1/PDZD8/HSP90B1/TPCN1/SLC39A4/NPTN/SLC8A1 27 GO:0060993 kidney morphogenesis 7/803 93/18722 0.104391148110335 0.28186819338987 TCF21/PDGFRB/BMP4/GPC3/BASP1/PKD1/PKD2 7 GO:1902807 negative regulation of cell cycle G1/S phase transition 7/803 93/18722 0.104391148110335 0.28186819338987 FHL1/KANK2/PTEN/GPNMB/PKD2/KLF4/ATM 7 GO:0033574 response to testosterone 4/803 42/18722 0.104426097306835 0.28186819338987 THBS1/TSPO/ROCK2/MSN 4 GO:0035019 somatic stem cell population maintenance 4/803 42/18722 0.104426097306835 0.28186819338987 LDB2/YAP1/ZFP36L2/SKI 4 GO:0045687 positive regulation of glial cell differentiation 4/803 42/18722 0.104426097306835 0.28186819338987 SERPINE2/BIN1/IL6ST/MDK 4 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/803 42/18722 0.104426097306835 0.28186819338987 NR3C1/KLF4/FOXO3/STAT3 4 GO:0034767 positive regulation of ion transmembrane transport 11/803 167/18722 0.104770082133789 0.28186819338987 THY1/FXYD1/FLNA/HSPA2/ATP1B1/PKD2/ITGB1/IFNGR2/ABL1/WNK1/ACTN4 11 GO:0003222 ventricular trabecula myocardium morphogenesis 2/803 13/18722 0.104866726582071 0.28186819338987 HEG1/ENG 2 GO:0010755 regulation of plasminogen activation 2/803 13/18722 0.104866726582071 0.28186819338987 SERPINE2/THBS1 2 GO:0014745 negative regulation of muscle adaptation 2/803 13/18722 0.104866726582071 0.28186819338987 IGFBP5/KLF4 2 GO:0014842 regulation of skeletal muscle satellite cell proliferation 2/803 13/18722 0.104866726582071 0.28186819338987 ANGPT1/STAT3 2 GO:0021554 optic nerve development 2/803 13/18722 0.104866726582071 0.28186819338987 EXT1/NAV2 2 GO:0021681 cerebellar granular layer development 2/803 13/18722 0.104866726582071 0.28186819338987 SERPINE2/MDK 2 GO:0031272 regulation of pseudopodium assembly 2/803 13/18722 0.104866726582071 0.28186819338987 CDC42EP5/CDC42EP3 2 GO:0031274 positive regulation of pseudopodium assembly 2/803 13/18722 0.104866726582071 0.28186819338987 CDC42EP5/CDC42EP3 2 GO:0032429 regulation of phospholipase A2 activity 2/803 13/18722 0.104866726582071 0.28186819338987 LRP1/PLA2R1 2 GO:0034135 regulation of toll-like receptor 2 signaling pathway 2/803 13/18722 0.104866726582071 0.28186819338987 MFHAS1/PJA2 2 GO:0036005 response to macrophage colony-stimulating factor 2/803 13/18722 0.104866726582071 0.28186819338987 CSF1/FER 2 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 2/803 13/18722 0.104866726582071 0.28186819338987 CSF1/FER 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/803 13/18722 0.104866726582071 0.28186819338987 PTEN/TIMP3 2 GO:0042362 fat-soluble vitamin biosynthetic process 2/803 13/18722 0.104866726582071 0.28186819338987 SNAI2/PLTP 2 GO:0048070 regulation of developmental pigmentation 2/803 13/18722 0.104866726582071 0.28186819338987 KITLG/ZEB2 2 GO:0051481 negative regulation of cytosolic calcium ion concentration 2/803 13/18722 0.104866726582071 0.28186819338987 LRP1/SLC8A1 2 GO:0060347 heart trabecula formation 2/803 13/18722 0.104866726582071 0.28186819338987 ADAMTS1/TGFBR3 2 GO:0060670 branching involved in labyrinthine layer morphogenesis 2/803 13/18722 0.104866726582071 0.28186819338987 RSPO3/SOCS3 2 GO:0060707 trophoblast giant cell differentiation 2/803 13/18722 0.104866726582071 0.28186819338987 SOCS3/HECTD1 2 GO:0061000 negative regulation of dendritic spine development 2/803 13/18722 0.104866726582071 0.28186819338987 PTEN/ASAP1 2 GO:0071696 ectodermal placode development 2/803 13/18722 0.104866726582071 0.28186819338987 TBX2/FRS2 2 GO:0072672 neutrophil extravasation 2/803 13/18722 0.104866726582071 0.28186819338987 IL1R1/MDK 2 GO:0090042 tubulin deacetylation 2/803 13/18722 0.104866726582071 0.28186819338987 FLNA/PRKAA1 2 GO:0120305 regulation of pigmentation 2/803 13/18722 0.104866726582071 0.28186819338987 KITLG/ZEB2 2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 2/803 13/18722 0.104866726582071 0.28186819338987 NRP2/PLXNB2 2 GO:1902947 regulation of tau-protein kinase activity 2/803 13/18722 0.104866726582071 0.28186819338987 HGF/CLU 2 GO:1903651 positive regulation of cytoplasmic transport 2/803 13/18722 0.104866726582071 0.28186819338987 DAB2/MSN 2 GO:1903977 positive regulation of glial cell migration 2/803 13/18722 0.104866726582071 0.28186819338987 CSF1/LRP1 2 GO:1905244 regulation of modification of synaptic structure 2/803 13/18722 0.104866726582071 0.28186819338987 ABL1/ITSN1 2 GO:0017038 protein import 13/803 206/18722 0.106598624940115 0.286314634961397 APOD/CD36/BMP4/APOE/ANGPT1/PRICKLE1/FLNA/RAB23/CLU/PIK3R1/TXNIP/PKIG/STAT3 13 GO:0006956 complement activation 9/803 130/18722 0.106752226082813 0.286314634961397 C7/MFAP4/C1R/C1S/CFD/C2/SERPING1/A2M/CLU 9 GO:0014823 response to activity 6/803 76/18722 0.107370156285473 0.286314634961397 RARRES2/COL4A2/PTEN/METRNL/PRKAA1/GCLM 6 GO:0043536 positive regulation of blood vessel endothelial cell migration 6/803 76/18722 0.107370156285473 0.286314634961397 THBS1/FGFR1/ANGPT1/PRKCA/ABL1/HSPB1 6 GO:0072028 nephron morphogenesis 6/803 76/18722 0.107370156285473 0.286314634961397 TCF21/PDGFRB/BMP4/GPC3/PKD1/PKD2 6 GO:0086001 cardiac muscle cell action potential 6/803 76/18722 0.107370156285473 0.286314634961397 GJA1/BIN1/FLNA/ATP1B1/CAMK2D/SLC8A1 6 GO:0001835 blastocyst hatching 3/803 27/18722 0.107439767752261 0.286314634961397 HS3ST6/CMTM3/SLC35E2B 3 GO:0001958 endochondral ossification 3/803 27/18722 0.107439767752261 0.286314634961397 COL1A1/BMP4/EXT1 3 GO:0002719 negative regulation of cytokine production involved in immune response 3/803 27/18722 0.107439767752261 0.286314634961397 ANGPT1/BST2/HLA-F 3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/803 27/18722 0.107439767752261 0.286314634961397 ATP1B1/CAMK2D/SLC8A1 3 GO:0031954 positive regulation of protein autophosphorylation 3/803 27/18722 0.107439767752261 0.286314634961397 GPNMB/RAP2A/RAP2B 3 GO:0034698 response to gonadotropin 3/803 27/18722 0.107439767752261 0.286314634961397 GATA6/TGFBR3/GCLM 3 GO:0035188 hatching 3/803 27/18722 0.107439767752261 0.286314634961397 HS3ST6/CMTM3/SLC35E2B 3 GO:0036075 replacement ossification 3/803 27/18722 0.107439767752261 0.286314634961397 COL1A1/BMP4/EXT1 3 GO:0060512 prostate gland morphogenesis 3/803 27/18722 0.107439767752261 0.286314634961397 HOXA13/BMP4/FRS2 3 GO:0071684 organism emergence from protective structure 3/803 27/18722 0.107439767752261 0.286314634961397 HS3ST6/CMTM3/SLC35E2B 3 GO:0002695 negative regulation of leukocyte activation 12/803 187/18722 0.107556185142519 0.286471762350749 BMP4/TWSG1/GPNMB/MDK/AXL/PRNP/PAG1/PRKAR1A/HLA-F/FER/ATM/NDFIP1 12 GO:0051592 response to calcium ion 10/803 149/18722 0.10785429831693 0.287112403314582 SPARC/THBS1/KCNMA1/CAMK2D/PKD2/TXNIP/SEC31A/SDC1/WNK1/PRKAA1 10 GO:0051055 negative regulation of lipid biosynthetic process 5/803 59/18722 0.108188024548534 0.287693594879461 BMP5/DKK3/SNAI2/APOE/PRKAA1 5 GO:0051568 histone H3-K4 methylation 5/803 59/18722 0.108188024548534 0.287693594879461 NNMT/KMT2A/ASH1L/KMT2E/RTF1 5 GO:0048640 negative regulation of developmental growth 8/803 112/18722 0.10840465344512 0.288115992578553 BMP4/GJA1/SEMA3B/PTEN/SOCS2/TGFBR2/SEMA6D/RTN4 8 GO:0002690 positive regulation of leukocyte chemotaxis 7/803 94/18722 0.108874995253147 0.288904058718568 RARRES2/CSF1/GAS6/THBS1/CMKLR1/MDK/WNK1 7 GO:0048704 embryonic skeletal system morphogenesis 7/803 94/18722 0.108874995253147 0.288904058718568 PDGFRA/COL11A1/BMP4/OSR2/RDH10/TWIST1/TGFBR2 7 GO:1902414 protein localization to cell junction 7/803 94/18722 0.108874995253147 0.288904058718568 HEG1/FLNA/VCL/CLSTN1/TJP1/HSPB1/JAK1 7 GO:0071216 cellular response to biotic stimulus 15/803 246/18722 0.109063110620983 0.289249292317139 SPON2/CD36/EDNRB/PLSCR4/PRKCA/VIM/TFPI/AXL/MTDH/TSPO/TXNIP/ABL1/CAPN2/SGMS1/LITAF 15 GO:0009100 glycoprotein metabolic process 22/803 387/18722 0.109919967223349 0.291366803070504 DCN/CYTL1/COL11A1/GXYLT2/CSGALNACT1/DSEL/MAN1A1/CSGALNACT2/SLC2A10/RAMP1/EXT1/PGM3/UGDH/PLCB1/SULF2/PCSK6/BMPR2/GALNT1/AMFR/TMEM59/CHPF2/DPY19L4 22 GO:0006612 protein targeting to membrane 9/803 131/18722 0.11053977325022 0.29285404326546 TRAM1/SEC61A1/TRAM2/PRNP/SEC62/STOM/MYO1C/ZDHHC21/ICMT 9 GO:0009615 response to virus 21/803 367/18722 0.110724293452212 0.293031489996142 SPON2/ACTA2/IFITM2/IFITM3/IFITM1/HTRA1/EXT1/CLU/SERINC3/BST2/IFNGR2/DDX17/ZMYND11/BNIP3L/IFNAR1/SERINC5/IFI16/PUM2/NPC2/HSPB1/TSPAN6 21 GO:0140694 non-membrane-bounded organelle assembly 21/803 367/18722 0.110724293452212 0.293031489996142 PDGFRA/PDGFRB/LMOD1/FSCN1/FLNA/NEBL/CFL2/ITGB1/CEP44/PRKAR1A/MAP9/PLEC/TPM1/ASAP1/SBDS/PRKAA1/MSN/PUM2/GSN/NEK7/AKAP13 21 GO:0070665 positive regulation of leukocyte proliferation 10/803 150/18722 0.111396109225455 0.294018150298132 IGFBP2/VCAM1/CSF1/KITLG/IL6ST/IGF2/HLA-A/CD81/TGFBR2/BST2 10 GO:0006509 membrane protein ectodomain proteolysis 4/803 43/18722 0.111450923398209 0.294018150298132 APOE/TIMP1/TIMP3/TIMP2 4 GO:0014002 astrocyte development 4/803 43/18722 0.111450923398209 0.294018150298132 LAMC3/VIM/LAMB2/LRP1 4 GO:0014014 negative regulation of gliogenesis 4/803 43/18722 0.111450923398209 0.294018150298132 TMEM98/TSPO/SKI/CERS2 4 GO:0120178 steroid hormone biosynthetic process 4/803 43/18722 0.111450923398209 0.294018150298132 BMP5/HSD17B2/DKK3/TSPO 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/803 43/18722 0.111450923398209 0.294018150298132 EFEMP2/PRKG1/PTEN/TPM1 4 GO:0010827 regulation of glucose transmembrane transport 6/803 77/18722 0.112481769921109 0.296267355957026 ENPP1/GPC3/IRS1/PIK3R1/RHOQ/PID1 6 GO:0021675 nerve development 6/803 77/18722 0.112481769921109 0.296267355957026 VCAM1/SERPINE2/EXT1/NRP2/SULF2/NAV2 6 GO:0055117 regulation of cardiac muscle contraction 6/803 77/18722 0.112481769921109 0.296267355957026 STC1/GATA4/BIN1/ATP1B1/CAMK2D/SLC8A1 6 GO:0042982 amyloid precursor protein metabolic process 7/803 95/18722 0.113459894605269 0.298528250396765 SPON1/APOE/BIN1/CLU/ROCK2/PRNP/RTN4 7 GO:0050764 regulation of phagocytosis 7/803 95/18722 0.113459894605269 0.298528250396765 GAS6/CD36/MFGE8/C2/PTEN/LRP1/CNN2 7 GO:0006081 cellular aldehyde metabolic process 5/803 60/18722 0.114110294331109 0.29913455706357 BMP5/DKK3/RDH10/ALDH9A1/GLO1 5 GO:0006893 Golgi to plasma membrane transport 5/803 60/18722 0.114110294331109 0.29913455706357 STXBP6/SPTBN1/PREPL/MACF1/GOLGA4 5 GO:0031638 zymogen activation 5/803 60/18722 0.114110294331109 0.29913455706357 C1R/SERPINE2/THBS1/PLAU/IFI16 5 GO:0033866 nucleoside bisphosphate biosynthetic process 5/803 60/18722 0.114110294331109 0.29913455706357 ELOVL2/PAPSS2/PDK4/PANK3/PAPSS1 5 GO:0034030 ribonucleoside bisphosphate biosynthetic process 5/803 60/18722 0.114110294331109 0.29913455706357 ELOVL2/PAPSS2/PDK4/PANK3/PAPSS1 5 GO:0034033 purine nucleoside bisphosphate biosynthetic process 5/803 60/18722 0.114110294331109 0.29913455706357 ELOVL2/PAPSS2/PDK4/PANK3/PAPSS1 5 GO:1903670 regulation of sprouting angiogenesis 5/803 60/18722 0.114110294331109 0.29913455706357 CREB3L1/THBS1/KLF4/TJP1/JAK1 5 GO:0097193 intrinsic apoptotic signaling pathway 17/803 288/18722 0.1149714692865 0.30084234199886 CREB3L1/MAEL/SNAI2/CLU/PIK3R1/NUPR1/SERINC3/TNFRSF1A/PLAUR/ABL1/SGMS1/SKIL/HIPK1/IFI16/ATM/HSPB1/USP47 17 GO:0030902 hindbrain development 10/803 151/18722 0.1150031094765 0.30084234199886 BMP5/SERPINE2/FLNA/NFIB/MDK/ITGB1/DLC1/ABL1/CEP290/NCOA1 10 GO:0055067 monovalent inorganic cation homeostasis 10/803 151/18722 0.1150031094765 0.30084234199886 C7/SPX/EDNRB/KCNMA1/ATP1B1/PDK4/SLC9A9/TMEM106B/EXT1/SLC8A1 10 GO:1904064 positive regulation of cation transmembrane transport 10/803 151/18722 0.1150031094765 0.30084234199886 THY1/FXYD1/FLNA/HSPA2/ATP1B1/PKD2/IFNGR2/ABL1/WNK1/ACTN4 10 GO:0000303 response to superoxide 3/803 28/18722 0.116693342300165 0.302407538992091 FBLN5/CD36/SOD3 3 GO:0006829 zinc ion transport 3/803 28/18722 0.116693342300165 0.302407538992091 SLC39A13/SLC39A6/SLC39A4 3 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 3/803 28/18722 0.116693342300165 0.302407538992091 PLPP1/LRP1/CISH 3 GO:0009065 glutamine family amino acid catabolic process 3/803 28/18722 0.116693342300165 0.302407538992091 GLS/DDAH2/OAT 3 GO:0010575 positive regulation of vascular endothelial growth factor production 3/803 28/18722 0.116693342300165 0.302407538992091 GATA4/IL6ST/SULF2 3 GO:0019098 reproductive behavior 3/803 28/18722 0.116693342300165 0.302407538992091 THRA/PTEN/NCOA1 3 GO:0034123 positive regulation of toll-like receptor signaling pathway 3/803 28/18722 0.116693342300165 0.302407538992091 MFHAS1/RTN4/PJA2 3 GO:0045671 negative regulation of osteoclast differentiation 3/803 28/18722 0.116693342300165 0.302407538992091 PIK3R1/FBN1/GPR137B 3 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 3/803 28/18722 0.116693342300165 0.302407538992091 PTPRD/SOCS2/SOCS3 3 GO:0090344 negative regulation of cell aging 3/803 28/18722 0.116693342300165 0.302407538992091 PTEN/TWIST1/ABL1 3 GO:1903020 positive regulation of glycoprotein metabolic process 3/803 28/18722 0.116693342300165 0.302407538992091 SLC2A10/RAMP1/PLCB1 3 GO:1903672 positive regulation of sprouting angiogenesis 3/803 28/18722 0.116693342300165 0.302407538992091 KLF4/TJP1/JAK1 3 GO:0051261 protein depolymerization 8/803 114/18722 0.116792936091403 0.302407538992091 MAP1B/PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/TAOK1/GSN 8 GO:0034637 cellular carbohydrate biosynthetic process 6/803 78/18722 0.11771468176298 0.302407538992091 ENPP1/CSGALNACT1/CSGALNACT2/IGF2/IRS1/EXT1 6 GO:0006775 fat-soluble vitamin metabolic process 4/803 44/18722 0.118679585655412 0.302407538992091 RBP1/CRABP1/SNAI2/PLTP 4 GO:0007528 neuromuscular junction development 4/803 44/18722 0.118679585655412 0.302407538992091 PDZRN3/COL4A1/LAMB2/PPFIBP1 4 GO:0031295 T cell costimulation 4/803 44/18722 0.118679585655412 0.302407538992091 LGALS1/CD81/DPP4/MAP3K8 4 GO:0032881 regulation of polysaccharide metabolic process 4/803 44/18722 0.118679585655412 0.302407538992091 ENPP1/IGF2/IRS1/CLTC 4 GO:0042269 regulation of natural killer cell mediated cytotoxicity 4/803 44/18722 0.118679585655412 0.302407538992091 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0045124 regulation of bone resorption 4/803 44/18722 0.118679585655412 0.302407538992091 PRKCA/PDK4/LTBP3/GPR137B 4 GO:0046006 regulation of activated T cell proliferation 4/803 44/18722 0.118679585655412 0.302407538992091 IGFBP2/IGF2/PRNP/PRKAR1A 4 GO:0048806 genitalia development 4/803 44/18722 0.118679585655412 0.302407538992091 PDGFRA/HOXA13/PKD1/AXL 4 GO:0050999 regulation of nitric-oxide synthase activity 4/803 44/18722 0.118679585655412 0.302407538992091 APOE/ACVR2A/DDAH2/ZDHHC21 4 GO:0051150 regulation of smooth muscle cell differentiation 4/803 44/18722 0.118679585655412 0.302407538992091 EFEMP2/PRDM6/BMP4/ENG 4 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 4/803 44/18722 0.118679585655412 0.302407538992091 MFHAS1/RTN4/PUM2/PJA2 4 GO:0001711 endodermal cell fate commitment 2/803 14/18722 0.118997912455372 0.302407538992091 GATA6/RTF1 2 GO:0001771 immunological synapse formation 2/803 14/18722 0.118997912455372 0.302407538992091 CD81/MSN 2 GO:0002475 antigen processing and presentation via MHC class Ib 2/803 14/18722 0.118997912455372 0.302407538992091 B2M/HLA-F 2 GO:0002517 T cell tolerance induction 2/803 14/18722 0.118997912455372 0.302407538992091 HLA-B/TGFBR2 2 GO:0003188 heart valve formation 2/803 14/18722 0.118997912455372 0.302407538992091 GATA4/TWIST1 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/803 14/18722 0.118997912455372 0.302407538992091 SERPINH1/TGFBR2 2 GO:0006047 UDP-N-acetylglucosamine metabolic process 2/803 14/18722 0.118997912455372 0.302407538992091 PGM3/UAP1 2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 2/803 14/18722 0.118997912455372 0.302407538992091 ANGPT1/PRLR 2 GO:0010421 hydrogen peroxide-mediated programmed cell death 2/803 14/18722 0.118997912455372 0.302407538992091 HGF/FOXO3 2 GO:0010457 centriole-centriole cohesion 2/803 14/18722 0.118997912455372 0.302407538992091 NIN/CEP44 2 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 2/803 14/18722 0.118997912455372 0.302407538992091 FBLN1/ACTN4 2 GO:0030007 cellular potassium ion homeostasis 2/803 14/18722 0.118997912455372 0.302407538992091 KCNMA1/ATP1B1 2 GO:0033212 iron import into cell 2/803 14/18722 0.118997912455372 0.302407538992091 CYBRD1/STEAP4 2 GO:0035641 locomotory exploration behavior 2/803 14/18722 0.118997912455372 0.302407538992091 APOE/DPP4 2 GO:0042415 norepinephrine metabolic process 2/803 14/18722 0.118997912455372 0.302407538992091 HAND2/EPAS1 2 GO:0042921 glucocorticoid receptor signaling pathway 2/803 14/18722 0.118997912455372 0.302407538992091 NR3C1/CLOCK 2 GO:0043951 negative regulation of cAMP-mediated signaling 2/803 14/18722 0.118997912455372 0.302407538992091 PDE3A/PDE3B 2 GO:0044764 multi-organism cellular process 2/803 14/18722 0.118997912455372 0.302407538992091 GAS6/TPCN1 2 GO:0045820 negative regulation of glycolytic process 2/803 14/18722 0.118997912455372 0.302407538992091 NUPR1/STAT3 2 GO:0046325 negative regulation of glucose import 2/803 14/18722 0.118997912455372 0.302407538992091 ENPP1/PID1 2 GO:0048681 negative regulation of axon regeneration 2/803 14/18722 0.118997912455372 0.302407538992091 PTEN/CERS2 2 GO:0051917 regulation of fibrinolysis 2/803 14/18722 0.118997912455372 0.302407538992091 FAP/THBS1 2 GO:0060576 intestinal epithelial cell development 2/803 14/18722 0.118997912455372 0.302407538992091 IL6ST/YAP1 2 GO:0070141 response to UV-A 2/803 14/18722 0.118997912455372 0.302407538992091 MMP2/TIMP1 2 GO:0072160 nephron tubule epithelial cell differentiation 2/803 14/18722 0.118997912455372 0.302407538992091 PROM1/YAP1 2 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 2/803 14/18722 0.118997912455372 0.302407538992091 FBLN1/ACTN4 2 GO:1901857 positive regulation of cellular respiration 2/803 14/18722 0.118997912455372 0.302407538992091 NUPR1/IFNAR1 2 GO:1902036 regulation of hematopoietic stem cell differentiation 2/803 14/18722 0.118997912455372 0.302407538992091 ABL1/N4BP2L2 2 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 2/803 14/18722 0.118997912455372 0.302407538992091 EFEMP2/ENG 2 GO:1905208 negative regulation of cardiocyte differentiation 2/803 14/18722 0.118997912455372 0.302407538992091 PRICKLE1/FRS2 2 GO:2001171 positive regulation of ATP biosynthetic process 2/803 14/18722 0.118997912455372 0.302407538992091 PID1/STAT3 2 GO:0030595 leukocyte chemotaxis 14/803 230/18722 0.119694996759545 0.304024072258325 RARRES2/SLIT2/CSF1/GAS6/ITGA1/THBS1/EDNRB/CMKLR1/MDK/DPP4/PLEC/WNK1/SBDS/MTUS1 14 GO:2000401 regulation of lymphocyte migration 5/803 61/18722 0.120184254444629 0.305030836441843 APOD/ECM1/WNK1/WASL/MSN 5 GO:0034504 protein localization to nucleus 17/803 290/18722 0.120213717129607 0.305030836441843 COL1A1/APOD/CD36/BMP4/TMEM98/ANGPT1/PRICKLE1/FLNA/MFHAS1/GLIS2/RAB23/PIK3R1/YAP1/TXNIP/PKIG/SYNE1/STAT3 17 GO:0042770 signal transduction in response to DNA damage 11/803 172/18722 0.121677277168582 0.308587438434663 SNAI2/TWIST1/NDRG1/SPRED1/ABL1/TAOK1/PLA2R1/ATRX/FOXO3/ATM/CLOCK 11 GO:0032147 activation of protein kinase activity 9/803 134/18722 0.122344731670833 0.310122436253572 GAS6/ANGPT1/PRLR/PRNP/TGFBR2/ABL1/WNK1/CCDC88A/COPS8 9 GO:0035335 peptidyl-tyrosine dephosphorylation 7/803 97/18722 0.122928369845875 0.311320153642388 PTPRD/PTEN/PTPRK/CDC25B/PTPRG/PTPRA/PTP4A2 7 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 6/803 79/18722 0.123066992143832 0.311320153642388 DCN/HGF/PDGFRA/PDGFRB/FGFR1/ANGPT1 6 GO:0032272 negative regulation of protein polymerization 6/803 79/18722 0.123066992143832 0.311320153642388 SLIT2/LMOD1/MYADM/SPTBN1/EPS8/GSN 6 GO:1901184 regulation of ERBB signaling pathway 6/803 79/18722 0.123066992143832 0.311320153642388 ITGA1/PLAUR/RTN4/FER/CCDC88A/SOS1 6 GO:0044088 regulation of vacuole organization 4/803 45/18722 0.126105323395452 0.317075104122429 LAPTM4B/TMEM106B/NUPR1/SCARB2 4 GO:0071364 cellular response to epidermal growth factor stimulus 4/803 45/18722 0.126105323395452 0.317075104122429 COL1A1/SNAI2/ZFP36L2/ZFP36L1 4 GO:0000305 response to oxygen radical 3/803 29/18722 0.126232266683318 0.317075104122429 FBLN5/CD36/SOD3 3 GO:0001773 myeloid dendritic cell activation 3/803 29/18722 0.126232266683318 0.317075104122429 TGFBR2/NOTCH2/LTBR 3 GO:0005979 regulation of glycogen biosynthetic process 3/803 29/18722 0.126232266683318 0.317075104122429 ENPP1/IGF2/IRS1 3 GO:0010962 regulation of glucan biosynthetic process 3/803 29/18722 0.126232266683318 0.317075104122429 ENPP1/IGF2/IRS1 3 GO:0022011 myelination in peripheral nervous system 3/803 29/18722 0.126232266683318 0.317075104122429 NDRG1/PLEC/SKI 3 GO:0032292 peripheral nervous system axon ensheathment 3/803 29/18722 0.126232266683318 0.317075104122429 NDRG1/PLEC/SKI 3 GO:0032366 intracellular sterol transport 3/803 29/18722 0.126232266683318 0.317075104122429 CES1/LRP6/NPC2 3 GO:0032367 intracellular cholesterol transport 3/803 29/18722 0.126232266683318 0.317075104122429 CES1/LRP6/NPC2 3 GO:0033028 myeloid cell apoptotic process 3/803 29/18722 0.126232266683318 0.317075104122429 KITLG/THRA/PTEN 3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 3/803 29/18722 0.126232266683318 0.317075104122429 CCND2/PKD1/PKD2 3 GO:0060969 negative regulation of gene silencing 3/803 29/18722 0.126232266683318 0.317075104122429 KCNQ1OT1/NCOR2/STAT3 3 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/803 29/18722 0.126232266683318 0.317075104122429 SNAI2/CLU/USP47 3 GO:0070301 cellular response to hydrogen peroxide 7/803 98/18722 0.127809469834497 0.320713647002919 HGF/AXL/KLF4/ABL1/SETX/FOXO3/PRKAA1 7 GO:1902882 regulation of response to oxidative stress 7/803 98/18722 0.127809469834497 0.320713647002919 HGF/FBLN5/GATA4/CD36/SESN3/FOXO3/HSPB1 7 GO:0045619 regulation of lymphocyte differentiation 11/803 174/18722 0.12884363861658 0.32314606747599 GAS6/BMP4/MDK/AXL/TGFBR2/ZFP36L2/ZFP36L1/ABL1/ZMIZ1/SOS1/NDFIP1 11 GO:0034612 response to tumor necrosis factor 15/803 253/18722 0.129014845096071 0.323412779109608 COL1A1/VCAM1/GAS6/AKAP12/THBS1/CLDN1/EXT1/ZFP36L2/ZFP36L1/TNFRSF1A/PID1/SGMS1/FOXO3/HIPK1/ACTN4 15 GO:0072676 lymphocyte migration 8/803 117/18722 0.130005483976927 0.325732333220582 APOD/ECM1/GAS6/EXT1/PLEC/WNK1/WASL/MSN 8 GO:1903364 positive regulation of cellular protein catabolic process 10/803 155/18722 0.130075174933429 0.325743255759958 APOE/PRICKLE1/CD81/PTEN/LRP1/CLU/NUPR1/DAB2/MSN/HECTD1 10 GO:0006605 protein targeting 18/803 314/18722 0.130308744561385 0.32616435762202 LTBP2/MAN1A1/TRAM1/CLU/TSPO/SEC61A1/TRAM2/PRNP/SCARB2/SEC62/NPEPPS/STOM/PRKAA1/MYO1C/BNIP3L/SORT1/ZDHHC21/ICMT 18 GO:0050777 negative regulation of immune response 12/803 194/18722 0.130550489233447 0.326350192746407 COL3A1/HLA-B/SERPING1/HLA-A/HTRA1/A2M/HLA-F/FER/IFI16/SERPINB9/NDFIP1/TSPAN6 12 GO:0098876 vesicle-mediated transport to the plasma membrane 9/803 136/18722 0.130577649069235 0.326350192746407 STXBP6/EHD2/ANKRD50/SPTBN1/PREPL/ACAP2/CLSTN1/MACF1/GOLGA4 9 GO:0010948 negative regulation of cell cycle process 17/803 294/18722 0.131117332623806 0.326350192746407 FHL1/BMP4/KANK2/PTEN/GPNMB/PKD2/APBB2/ZFP36L2/ZFP36L1/KLF4/PRKAR1A/TAOK1/ATRX/TERF1/ATM/CLOCK/USP47 17 GO:2000242 negative regulation of reproductive process 5/803 63/18722 0.132773396837358 0.326350192746407 BMP4/TIMP1/GJA1/SERPINF1/PRKAR1A 5 GO:0060996 dendritic spine development 7/803 99/18722 0.1327866758231 0.326350192746407 APOE/PTEN/PDLIM5/ABI2/ASAP1/WASL/ITSN1 7 GO:0006268 DNA unwinding involved in DNA replication 2/803 15/18722 0.133564531573744 0.326350192746407 PURA/RECQL 2 GO:0006684 sphingomyelin metabolic process 2/803 15/18722 0.133564531573744 0.326350192746407 ABCA8/SGMS1 2 GO:0014841 skeletal muscle satellite cell proliferation 2/803 15/18722 0.133564531573744 0.326350192746407 ANGPT1/STAT3 2 GO:0014857 regulation of skeletal muscle cell proliferation 2/803 15/18722 0.133564531573744 0.326350192746407 ANGPT1/STAT3 2 GO:0015697 quaternary ammonium group transport 2/803 15/18722 0.133564531573744 0.326350192746407 SLC22A3/SLC38A2 2 GO:0016114 terpenoid biosynthetic process 2/803 15/18722 0.133564531573744 0.326350192746407 RBP1/RDH10 2 GO:0021542 dentate gyrus development 2/803 15/18722 0.133564531573744 0.326350192746407 PTEN/MDK 2 GO:0030252 growth hormone secretion 2/803 15/18722 0.133564531573744 0.326350192746407 LTBP4/ITSN1 2 GO:0031269 pseudopodium assembly 2/803 15/18722 0.133564531573744 0.326350192746407 CDC42EP5/CDC42EP3 2 GO:0031958 corticosteroid receptor signaling pathway 2/803 15/18722 0.133564531573744 0.326350192746407 NR3C1/CLOCK 2 GO:0032354 response to follicle-stimulating hormone 2/803 15/18722 0.133564531573744 0.326350192746407 TGFBR3/GCLM 2 GO:0032488 Cdc42 protein signal transduction 2/803 15/18722 0.133564531573744 0.326350192746407 APOE/ABL1 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/803 15/18722 0.133564531573744 0.326350192746407 KANK2/STRN3 2 GO:0033599 regulation of mammary gland epithelial cell proliferation 2/803 15/18722 0.133564531573744 0.326350192746407 ROBO1/RTN4 2 GO:0042074 cell migration involved in gastrulation 2/803 15/18722 0.133564531573744 0.326350192746407 GPC3/EPB41L5 2 GO:0042249 establishment of planar polarity of embryonic epithelium 2/803 15/18722 0.133564531573744 0.326350192746407 CTHRC1/PTK7 2 GO:0042994 cytoplasmic sequestering of transcription factor 2/803 15/18722 0.133564531573744 0.326350192746407 PKD1/PKD2 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/803 15/18722 0.133564531573744 0.326350192746407 SNAI2/TWIST1 2 GO:0043584 nose development 2/803 15/18722 0.133564531573744 0.326350192746407 RDH10/SKI 2 GO:0044406 adhesion of symbiont to host 2/803 15/18722 0.133564531573744 0.326350192746407 GAS6/CD81 2 GO:0045475 locomotor rhythm 2/803 15/18722 0.133564531573744 0.326350192746407 PTEN/ZFHX3 2 GO:0045725 positive regulation of glycogen biosynthetic process 2/803 15/18722 0.133564531573744 0.326350192746407 IGF2/IRS1 2 GO:0045986 negative regulation of smooth muscle contraction 2/803 15/18722 0.133564531573744 0.326350192746407 PRKG1/KCNMA1 2 GO:0046007 negative regulation of activated T cell proliferation 2/803 15/18722 0.133564531573744 0.326350192746407 PRNP/PRKAR1A 2 GO:0046184 aldehyde biosynthetic process 2/803 15/18722 0.133564531573744 0.326350192746407 BMP5/DKK3 2 GO:0046321 positive regulation of fatty acid oxidation 2/803 15/18722 0.133564531573744 0.326350192746407 IRS1/TWIST1 2 GO:0051290 protein heterotetramerization 2/803 15/18722 0.133564531573744 0.326350192746407 PKD1/PKD2 2 GO:0051775 response to redox state 2/803 15/18722 0.133564531573744 0.326350192746407 VASN/CLOCK 2 GO:0060049 regulation of protein glycosylation 2/803 15/18722 0.133564531573744 0.326350192746407 RAMP1/TMEM59 2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 2/803 15/18722 0.133564531573744 0.326350192746407 GAS1/SAR1A 2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 2/803 15/18722 0.133564531573744 0.326350192746407 CD81/SAR1A 2 GO:0071380 cellular response to prostaglandin E stimulus 2/803 15/18722 0.133564531573744 0.326350192746407 PTGER2/PRKAA1 2 GO:0072044 collecting duct development 2/803 15/18722 0.133564531573744 0.326350192746407 BMP4/PKD1 2 GO:0090110 COPII-coated vesicle cargo loading 2/803 15/18722 0.133564531573744 0.326350192746407 SEC31A/SAR1A 2 GO:0090594 inflammatory response to wounding 2/803 15/18722 0.133564531573744 0.326350192746407 TIMP1/MDK 2 GO:0097468 programmed cell death in response to reactive oxygen species 2/803 15/18722 0.133564531573744 0.326350192746407 HGF/FOXO3 2 GO:1901741 positive regulation of myoblast fusion 2/803 15/18722 0.133564531573744 0.326350192746407 EHD2/CAPN2 2 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 2/803 15/18722 0.133564531573744 0.326350192746407 NCOR2/STAT3 2 GO:2000345 regulation of hepatocyte proliferation 2/803 15/18722 0.133564531573744 0.326350192746407 MDK/SULF2 2 GO:2000402 negative regulation of lymphocyte migration 2/803 15/18722 0.133564531573744 0.326350192746407 APOD/WASL 2 GO:0010828 positive regulation of glucose transmembrane transport 4/803 46/18722 0.133721107858185 0.326350192746407 GPC3/IRS1/PIK3R1/RHOQ 4 GO:0031294 lymphocyte costimulation 4/803 46/18722 0.133721107858185 0.326350192746407 LGALS1/CD81/DPP4/MAP3K8 4 GO:0071827 plasma lipoprotein particle organization 4/803 46/18722 0.133721107858185 0.326350192746407 PLA2G2A/APOE/PLTP/ABCA5 4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 4/803 46/18722 0.133721107858185 0.326350192746407 CCND2/ADAMTS1/PLCB1/KMT2E 4 GO:1900271 regulation of long-term synaptic potentiation 4/803 46/18722 0.133721107858185 0.326350192746407 APOE/PRNP/ABL1/NPTN 4 GO:2000107 negative regulation of leukocyte apoptotic process 4/803 46/18722 0.133721107858185 0.326350192746407 KITLG/GAS6/BMP4/AXL 4 GO:0008589 regulation of smoothened signaling pathway 6/803 81/18722 0.134121558734319 0.326847552223517 ENPP1/SERPINE2/GPC3/GAS1/GLIS2/TXNDC15 6 GO:0060968 regulation of gene silencing 6/803 81/18722 0.134121558734319 0.326847552223517 MAEL/BMP4/KCNQ1OT1/NCOR2/STAT3/PUM2 6 GO:1903533 regulation of protein targeting 6/803 81/18722 0.134121558734319 0.326847552223517 PRNP/NPEPPS/STOM/PRKAA1/MYO1C/BNIP3L 6 GO:0055074 calcium ion homeostasis 25/803 460/18722 0.134350829920834 0.327246330232182 PDGFRA/STC1/THY1/PTGFR/CD36/EDNRB/LPAR1/APOE/CAMK2N1/GJA1/CMKLR1/PTGER2/ATP1B1/CAMK2D/PKD1/LRP1/PKD2/LRP6/PRNP/ABL1/PDZD8/HSP90B1/TPCN1/NPTN/SLC8A1 25 GO:0034754 cellular hormone metabolic process 9/803 137/18722 0.13480102760877 0.328182579910804 BMP5/PDGFRA/RBP1/HSD17B2/CRABP1/DKK3/ECE1/RDH10/TSPO 9 GO:0031669 cellular response to nutrient levels 13/803 215/18722 0.134881767000005 0.32821888250953 COL1A1/SNAI2/GAS6/KANK2/PDK4/SESN3/BMPR2/SLC38A2/SLC39A4/FOXO3/PRKAA1/IFI16/NCOA1 13 GO:0001818 negative regulation of cytokine production 20/803 357/18722 0.135830632611019 0.329908543839155 HGF/APOD/GATA6/GAS6/THBS1/ANGPT1/CMKLR1/SLC2A10/TWSG1/LAPTM4B/GPNMB/AXL/TSPO/PRNP/TWIST1/BST2/KLF4/HLA-F/NPTN/NDFIP1 20 GO:0000132 establishment of mitotic spindle orientation 3/803 30/18722 0.136039303275833 0.329908543839155 GJA1/SPRY1/ITGB1 3 GO:0017145 stem cell division 3/803 30/18722 0.136039303275833 0.329908543839155 MLLT3/EXT1/ZFP36L2 3 GO:0036296 response to increased oxygen levels 3/803 30/18722 0.136039303275833 0.329908543839155 COL1A1/PDPN/PDGFRB 3 GO:0045940 positive regulation of steroid metabolic process 3/803 30/18722 0.136039303275833 0.329908543839155 APOE/CES1/PRKAA1 3 GO:0090314 positive regulation of protein targeting to membrane 3/803 30/18722 0.136039303275833 0.329908543839155 PRNP/STOM/MYO1C 3 GO:2000637 positive regulation of gene silencing by miRNA 3/803 30/18722 0.136039303275833 0.329908543839155 BMP4/STAT3/PUM2 3 GO:1902107 positive regulation of leukocyte differentiation 10/803 157/18722 0.137991047255181 0.334316502242145 CSF1/KITLG/GAS6/PRKCA/MDK/AXL/TGFBR2/ZFP36L1/NOTCH2/ZMIZ1 10 GO:1903708 positive regulation of hemopoiesis 10/803 157/18722 0.137991047255181 0.334316502242145 CSF1/KITLG/GAS6/PRKCA/MDK/AXL/TGFBR2/ZFP36L1/NOTCH2/ZMIZ1 10 GO:0007224 smoothened signaling pathway 9/803 138/18722 0.139094697581332 0.336298338471001 ENPP1/SERPINE2/GPC3/GAS1/GLIS2/EXT1/TGFBR2/HIPK1/TXNDC15 9 GO:0016126 sterol biosynthetic process 5/803 64/18722 0.139281201151748 0.336298338471001 APOE/CES1/CYB5R3/PRKAA1/MBTPS1 5 GO:0032507 maintenance of protein location in cell 5/803 64/18722 0.139281201151748 0.336298338471001 GJA1/TSPO/SYNE1/CCDC88A/GSN 5 GO:0045670 regulation of osteoclast differentiation 5/803 64/18722 0.139281201151748 0.336298338471001 CSF1/PIK3R1/NOTCH2/FBN1/GPR137B 5 GO:0045995 regulation of embryonic development 5/803 64/18722 0.139281201151748 0.336298338471001 WNT2/LAMA2/LAMA4/PHLDB1/PLCB1 5 GO:0046530 photoreceptor cell differentiation 5/803 64/18722 0.139281201151748 0.336298338471001 THY1/PROM1/TUG1/STAT3/CEP290 5 GO:0050771 negative regulation of axonogenesis 5/803 64/18722 0.139281201151748 0.336298338471001 THY1/SEMA3B/PTEN/SEMA6D/RTN4 5 GO:0043405 regulation of MAP kinase activity 11/803 177/18722 0.140016568790265 0.337910267177281 TNXB/KITLG/PDGFRB/BMP4/THBS1/APOE/FGFR1/SPRY1/ROBO1/HIPK3/AKAP13 11 GO:0007595 lactation 4/803 47/18722 0.141519674637901 0.340713229234464 PRLR/NCOR2/SOCS2/NCOA1 4 GO:0019884 antigen processing and presentation of exogenous antigen 4/803 47/18722 0.141519674637901 0.340713229234464 HLA-A/B2M/HLA-F/LNPEP 4 GO:0031641 regulation of myelination 4/803 47/18722 0.141519674637901 0.340713229234464 HGF/TMEM98/PTEN/LPIN1 4 GO:0101023 vascular endothelial cell proliferation 4/803 47/18722 0.141519674637901 0.340713229234464 FGFR1/IGF2/MDK/STAT3 4 GO:1905562 regulation of vascular endothelial cell proliferation 4/803 47/18722 0.141519674637901 0.340713229234464 FGFR1/IGF2/MDK/STAT3 4 GO:1901617 organic hydroxy compound biosynthetic process 14/803 237/18722 0.14168463392117 0.340945745526522 BMP5/HAND2/DKK3/SNAI2/APOE/ZEB2/CES1/PLTP/H6PD/CYB5R3/OSBPL1A/PRKAA1/MBTPS1/IPMK 14 GO:0042102 positive regulation of T cell proliferation 7/803 101/18722 0.143023477807922 0.344001476290545 IGFBP2/VCAM1/IL6ST/IGF2/HLA-A/CD81/TGFBR2 7 GO:0030216 keratinocyte differentiation 9/803 139/18722 0.143457857642941 0.344713676244675 PPL/PALLD/ROCK2/YAP1/TXNIP/ZFP36L1/PLEC/FOSL2/JAG1 9 GO:0051783 regulation of nuclear division 9/803 139/18722 0.143457857642941 0.344713676244675 PDE3A/PDGFRB/HOXA13/BMP4/IGF2/CCDC8/PLCB1/PRKAR1A/ATM 9 GO:0007163 establishment or maintenance of cell polarity 13/803 218/18722 0.145151619956147 0.348615595906239 MAP1B/FSCN1/GJA1/SPRY1/RND3/PTK7/DST/PKD1/ROCK2/ITGB1/MSN/GSN/AMOTL2 13 GO:0038034 signal transduction in absence of ligand 5/803 65/18722 0.145925965366849 0.348672138565694 SRPX/KITLG/SNAI2/FGFR1/FOXO3 5 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 5/803 65/18722 0.145925965366849 0.348672138565694 SRPX/KITLG/SNAI2/FGFR1/FOXO3 5 GO:0002828 regulation of type 2 immune response 3/803 31/18722 0.146097129697752 0.348672138565694 ECM1/CD81/NDFIP1 3 GO:0008045 motor neuron axon guidance 3/803 31/18722 0.146097129697752 0.348672138565694 SLIT2/CHN1/ALCAM 3 GO:0048566 embryonic digestive tract development 3/803 31/18722 0.146097129697752 0.348672138565694 TCF21/RARRES2/PDGFRA 3 GO:0048710 regulation of astrocyte differentiation 3/803 31/18722 0.146097129697752 0.348672138565694 SERPINE2/BIN1/IL6ST 3 GO:0055022 negative regulation of cardiac muscle tissue growth 3/803 31/18722 0.146097129697752 0.348672138565694 GJA1/PTEN/TGFBR2 3 GO:0060148 positive regulation of posttranscriptional gene silencing 3/803 31/18722 0.146097129697752 0.348672138565694 BMP4/STAT3/PUM2 3 GO:0061117 negative regulation of heart growth 3/803 31/18722 0.146097129697752 0.348672138565694 GJA1/PTEN/TGFBR2 3 GO:0070528 protein kinase C signaling 3/803 31/18722 0.146097129697752 0.348672138565694 FIBIN/AKAP12/MYADM 3 GO:0070723 response to cholesterol 3/803 31/18722 0.146097129697752 0.348672138565694 CES1/LRP6/TGFBR2 3 GO:0071480 cellular response to gamma radiation 3/803 31/18722 0.146097129697752 0.348672138565694 CRYAB/YAP1/ATM 3 GO:2000144 positive regulation of DNA-templated transcription, initiation 3/803 31/18722 0.146097129697752 0.348672138565694 TWIST1/SETX/MED13 3 GO:0046488 phosphatidylinositol metabolic process 10/803 159/18722 0.146154185640253 0.348672138565694 PDGFRB/PTEN/PIK3R1/SOCS2/CISH/LPGAT1/PLCB1/SOCS3/ATM/IPMK 10 GO:0006941 striated muscle contraction 11/803 179/18722 0.147742196543684 0.349592886125827 STC1/GATA4/GJA1/BIN1/FLNA/ATP1B1/CAMK2D/SMAD5/TPM1/SLC8A1/GSN 11 GO:1901991 negative regulation of mitotic cell cycle phase transition 11/803 179/18722 0.147742196543684 0.349592886125827 FHL1/KANK2/PTEN/GPNMB/PKD2/ZFP36L2/ZFP36L1/KLF4/TAOK1/ATM/USP47 11 GO:0007292 female gamete generation 9/803 140/18722 0.147889659734361 0.349592886125827 PDE3A/ADAMTS1/MDK/CDC25B/PRKAR1A/FOXO3/ZMIZ1/SOS1/USP9X 9 GO:0046165 alcohol biosynthetic process 9/803 140/18722 0.147889659734361 0.349592886125827 BMP5/DKK3/APOE/CES1/H6PD/CYB5R3/PRKAA1/MBTPS1/IPMK 9 GO:0045833 negative regulation of lipid metabolic process 7/803 102/18722 0.148279903331706 0.349592886125827 APOD/BMP5/DKK3/SNAI2/APOE/PDE3B/PRKAA1 7 GO:0062014 negative regulation of small molecule metabolic process 7/803 102/18722 0.148279903331706 0.349592886125827 BMP5/DKK3/SNAI2/APOE/NUPR1/PID1/STAT3 7 GO:1902106 negative regulation of leukocyte differentiation 7/803 102/18722 0.148279903331706 0.349592886125827 BMP4/TMEM176A/TMEM176B/MDK/PIK3R1/FBN1/GPR137B 7 GO:0001977 renal system process involved in regulation of blood volume 2/803 16/18722 0.148503355959587 0.349592886125827 GAS6/GJA1 2 GO:0002921 negative regulation of humoral immune response 2/803 16/18722 0.148503355959587 0.349592886125827 SERPING1/A2M 2 GO:0021535 cell migration in hindbrain 2/803 16/18722 0.148503355959587 0.349592886125827 FLNA/ITGB1 2 GO:0021783 preganglionic parasympathetic fiber development 2/803 16/18722 0.148503355959587 0.349592886125827 NRP2/NAV2 2 GO:0030033 microvillus assembly 2/803 16/18722 0.148503355959587 0.349592886125827 FSCN1/RAP2A 2 GO:0031268 pseudopodium organization 2/803 16/18722 0.148503355959587 0.349592886125827 CDC42EP5/CDC42EP3 2 GO:0034374 low-density lipoprotein particle remodeling 2/803 16/18722 0.148503355959587 0.349592886125827 PLA2G2A/APOE 2 GO:0045651 positive regulation of macrophage differentiation 2/803 16/18722 0.148503355959587 0.349592886125827 CSF1/PRKCA 2 GO:0046037 GMP metabolic process 2/803 16/18722 0.148503355959587 0.349592886125827 CASK/MAGI3 2 GO:0048557 embryonic digestive tract morphogenesis 2/803 16/18722 0.148503355959587 0.349592886125827 TCF21/PDGFRA 2 GO:0051014 actin filament severing 2/803 16/18722 0.148503355959587 0.349592886125827 CFL2/GSN 2 GO:0055089 fatty acid homeostasis 2/803 16/18722 0.148503355959587 0.349592886125827 APOE/PRKAA1 2 GO:0071361 cellular response to ethanol 2/803 16/18722 0.148503355959587 0.349592886125827 PTEN/PRKAA1 2 GO:0072148 epithelial cell fate commitment 2/803 16/18722 0.148503355959587 0.349592886125827 PDPN/HOXA13 2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 2/803 16/18722 0.148503355959587 0.349592886125827 DCN/ADGRA2 2 GO:1901163 regulation of trophoblast cell migration 2/803 16/18722 0.148503355959587 0.349592886125827 TIMP1/GJA1 2 GO:1904683 regulation of metalloendopeptidase activity 2/803 16/18722 0.148503355959587 0.349592886125827 TIMP3/STAT3 2 GO:1904948 midbrain dopaminergic neuron differentiation 2/803 16/18722 0.148503355959587 0.349592886125827 WNT2/LRP6 2 GO:2001212 regulation of vasculogenesis 2/803 16/18722 0.148503355959587 0.349592886125827 RRAS/RIN2 2 GO:2001224 positive regulation of neuron migration 2/803 16/18722 0.148503355959587 0.349592886125827 FLNA/MDK 2 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/803 16/18722 0.148503355959587 0.349592886125827 PLAUR/GSN 2 GO:0002673 regulation of acute inflammatory response 4/803 48/18722 0.149493554945127 0.350929785761018 EDNRB/OSMR/IL6ST/ASH1L 4 GO:0002715 regulation of natural killer cell mediated immunity 4/803 48/18722 0.149493554945127 0.350929785761018 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0042149 cellular response to glucose starvation 4/803 48/18722 0.149493554945127 0.350929785761018 SESN3/FOXO3/PRKAA1/IFI16 4 GO:0042908 xenobiotic transport 4/803 48/18722 0.149493554945127 0.350929785761018 SLC22A3/ABCA8/GJA1/CLDN1 4 GO:0045912 negative regulation of carbohydrate metabolic process 4/803 48/18722 0.149493554945127 0.350929785761018 ENPP1/NUPR1/STAT3/CLTC 4 GO:0120009 intermembrane lipid transfer 4/803 48/18722 0.149493554945127 0.350929785761018 APOE/PLTP/TSPO/NPC2 4 GO:0090150 establishment of protein localization to membrane 15/803 260/18722 0.150916053440969 0.354102325861964 SPTBN1/ATP1B1/TRAM1/SEC61A1/TRAM2/PRNP/SEC62/PREPL/STOM/CLSTN1/MYO1C/ZDHHC21/MACF1/GOLGA4/ICMT 15 GO:0006112 energy reserve metabolic process 6/803 84/18722 0.151544161641025 0.355074807303643 ENPP1/IL6ST/IGF2/IRS1/PID1/RB1CC1 6 GO:0032508 DNA duplex unwinding 6/803 84/18722 0.151544161641025 0.355074807303643 CHD9/PURA/ATRX/SETX/RECQL/NAV2 6 GO:0097061 dendritic spine organization 6/803 84/18722 0.151544161641025 0.355074807303643 APOE/PTEN/PDLIM5/PRNP/ABI2/WASL 6 GO:0032886 regulation of microtubule-based process 14/803 240/18722 0.151744940352448 0.355378239829642 MAP1B/EPHA3/PHLDB1/PKD1/GNAI1/ROCK2/MPDZ/NIN/ABL1/MAP9/TAOK1/PRKAA1/CLTC/MACF1 14 GO:0071902 positive regulation of protein serine/threonine kinase activity 12/803 200/18722 0.152253367241616 0.356401544162768 CCND2/KITLG/PDGFRB/THBS1/FGFR1/IGF2/ROBO1/PKD1/PKD2/BMPR2/TAOK1/AKAP13 12 GO:0014015 positive regulation of gliogenesis 5/803 66/18722 0.152703604197645 0.356618346852205 SERPINE2/BIN1/IL6ST/MDK/TSPO 5 GO:0042446 hormone biosynthetic process 5/803 66/18722 0.152703604197645 0.356618346852205 BMP5/HSD17B2/DKK3/TSPO/H6PD 5 GO:0045600 positive regulation of fat cell differentiation 5/803 66/18722 0.152703604197645 0.356618346852205 RARRES2/CMKLR1/ZFP36L1/METRNL/AAMDC 5 GO:0050766 positive regulation of phagocytosis 5/803 66/18722 0.152703604197645 0.356618346852205 GAS6/CD36/MFGE8/C2/LRP1 5 GO:0072678 T cell migration 5/803 66/18722 0.152703604197645 0.356618346852205 APOD/ECM1/PLEC/WNK1/MSN 5 GO:0050868 negative regulation of T cell activation 8/803 122/18722 0.153643248086187 0.358644772920286 BMP4/TWSG1/GPNMB/MDK/PRNP/PAG1/PRKAR1A/NDFIP1 8 GO:0006874 cellular calcium ion homeostasis 24/803 448/18722 0.155682435890427 0.363234733434568 PDGFRA/STC1/THY1/PTGFR/CD36/EDNRB/LPAR1/APOE/GJA1/CMKLR1/PTGER2/ATP1B1/CAMK2D/PKD1/LRP1/PKD2/LRP6/PRNP/ABL1/PDZD8/HSP90B1/TPCN1/NPTN/SLC8A1 24 GO:0019835 cytolysis 3/803 32/18722 0.156388421925712 0.363860322781896 C7/PLA2G2A/APOL1 3 GO:0021799 cerebral cortex radially oriented cell migration 3/803 32/18722 0.156388421925712 0.363860322781896 LAMB1/RTN4/ZMIZ1 3 GO:0033687 osteoblast proliferation 3/803 32/18722 0.156388421925712 0.363860322781896 CTHRC1/OSR2/ABL1 3 GO:0045761 regulation of adenylate cyclase activity 3/803 32/18722 0.156388421925712 0.363860322781896 PALM/EDNRB/TIMP2 3 GO:0048841 regulation of axon extension involved in axon guidance 3/803 32/18722 0.156388421925712 0.363860322781896 SEMA3B/BMPR2/SEMA6D 3 GO:0090022 regulation of neutrophil chemotaxis 3/803 32/18722 0.156388421925712 0.363860322781896 SLIT2/MDK/DPP4 3 GO:0002709 regulation of T cell mediated immunity 6/803 85/18722 0.157566020184749 0.365057425345824 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F 6 GO:0010507 negative regulation of autophagy 6/803 85/18722 0.157566020184749 0.365057425345824 HGF/GATA4/TSPO/NUPR1/STAT3/CTSA 6 GO:0045069 regulation of viral genome replication 6/803 85/18722 0.157566020184749 0.365057425345824 IFITM2/IFITM3/IFITM1/BST2/FAM111A/IFI16 6 GO:0097006 regulation of plasma lipoprotein particle levels 6/803 85/18722 0.157566020184749 0.365057425345824 PLA2G2A/CD36/APOE/PLTP/VLDLR/ABCA5 6 GO:0001913 T cell mediated cytotoxicity 4/803 49/18722 0.157635105649731 0.365057425345824 HLA-B/HLA-A/B2M/HLA-F 4 GO:0009409 response to cold 4/803 49/18722 0.157635105649731 0.365057425345824 THRA/HSPA2/METRNL/PRKAA1 4 GO:0030857 negative regulation of epithelial cell differentiation 4/803 49/18722 0.157635105649731 0.365057425345824 SPRY1/YAP1/SPRED1/JAG1 4 GO:0051445 regulation of meiotic cell cycle 4/803 49/18722 0.157635105649731 0.365057425345824 PDE3A/PLCB1/CDC25B/PRKAR1A 4 GO:0070849 response to epidermal growth factor 4/803 49/18722 0.157635105649731 0.365057425345824 COL1A1/SNAI2/ZFP36L2/ZFP36L1 4 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 4/803 49/18722 0.157635105649731 0.365057425345824 MMP2/IGFBP5/GJA1/ADAMTS1 4 GO:0044262 cellular carbohydrate metabolic process 16/803 283/18722 0.159357524947535 0.368874939363235 ENPP1/NNMT/CSGALNACT1/CSGALNACT2/IL6ST/IGF2/IRS1/PTEN/PDK4/EXT1/NUPR1/SCARB2/SLC5A3/STAT3/GNPTG/RB1CC1 16 GO:0006879 cellular iron ion homeostasis 5/803 67/18722 0.159609896473989 0.369116393237156 CYBRD1/STEAP4/SLC40A1/FRRS1/NDFIP1 5 GO:1902117 positive regulation of organelle assembly 5/803 67/18722 0.159609896473989 0.369116393237156 FSCN1/SDC1/ASAP1/MSN/CCDC88A 5 GO:0051260 protein homooligomerization 11/803 182/18722 0.15973565202516 0.369235957810593 KCTD12/STEAP4/GLS/B2M/PKD2/PRNP/TIFA/KCTD2/ALDH9A1/TMEM120A/ATL3 11 GO:0019722 calcium-mediated signaling 12/803 202/18722 0.159881696836215 0.36940228935374 VCAM1/PTGFR/EDNRB/CMKLR1/ATP1B1/CAMK2D/LMCD1/NFAT5/PRNP/MCTP2/PRKAA1/SLC8A1 12 GO:0034763 negative regulation of transmembrane transport 9/803 143/18722 0.161587760776176 0.372484608258591 ENPP1/THBS1/BIN1/PTEN/CAMK2D/PKD2/TWIST1/SESTD1/PID1 9 GO:0015850 organic hydroxy compound transport 16/803 284/18722 0.162608192443126 0.372484608258591 SLC22A3/ABCA8/CD36/APOE/CES1/SLC16A7/LRP1/PLTP/CLU/TSPO/LRP6/SLC5A3/OSBPL1A/PRKAA1/NPC2/ABCA5 16 GO:0015908 fatty acid transport 6/803 86/18722 0.163690628689136 0.372484608258591 PLA2G2A/SPX/CD36/THBS1/APOE/PLA2R1 6 GO:0022406 membrane docking 6/803 86/18722 0.163690628689136 0.372484608258591 VCAM1/STX2/PDZD8/MSN/CEP290/ESYT2 6 GO:0060761 negative regulation of response to cytokine stimulus 6/803 86/18722 0.163690628689136 0.372484608258591 SLIT2/ECM1/SLIT3/GAS6/ROBO1/KLF4 6 GO:0001710 mesodermal cell fate commitment 2/803 17/18722 0.16375576841212 0.372484608258591 BMP4/KLF4 2 GO:0001829 trophectodermal cell differentiation 2/803 17/18722 0.16375576841212 0.372484608258591 YAP1/SP3 2 GO:0006390 mitochondrial transcription 2/803 17/18722 0.16375576841212 0.372484608258591 FOXO3/PRKAA1 2 GO:0006895 Golgi to endosome transport 2/803 17/18722 0.16375576841212 0.372484608258591 MON2/SORT1 2 GO:0009084 glutamine family amino acid biosynthetic process 2/803 17/18722 0.16375576841212 0.372484608258591 GLS/OAT 2 GO:0010934 macrophage cytokine production 2/803 17/18722 0.16375576841212 0.372484608258591 SPON2/CD36 2 GO:0010935 regulation of macrophage cytokine production 2/803 17/18722 0.16375576841212 0.372484608258591 SPON2/CD36 2 GO:0014856 skeletal muscle cell proliferation 2/803 17/18722 0.16375576841212 0.372484608258591 ANGPT1/STAT3 2 GO:0016045 detection of bacterium 2/803 17/18722 0.16375576841212 0.372484608258591 HLA-B/HLA-A 2 GO:0033623 regulation of integrin activation 2/803 17/18722 0.16375576841212 0.372484608258591 FBLIM1/PIEZO1 2 GO:0035729 cellular response to hepatocyte growth factor stimulus 2/803 17/18722 0.16375576841212 0.372484608258591 HGF/GCLM 2 GO:0036035 osteoclast development 2/803 17/18722 0.16375576841212 0.372484608258591 NOTCH2/FBN1 2 GO:0042953 lipoprotein transport 2/803 17/18722 0.16375576841212 0.372484608258591 CD36/LRP1 2 GO:0045198 establishment of epithelial cell apical/basal polarity 2/803 17/18722 0.16375576841212 0.372484608258591 PTK7/MSN 2 GO:0048339 paraxial mesoderm development 2/803 17/18722 0.16375576841212 0.372484608258591 YAP1/EPB41L5 2 GO:0060033 anatomical structure regression 2/803 17/18722 0.16375576841212 0.372484608258591 CD248/SMAD5 2 GO:0061158 3'-UTR-mediated mRNA destabilization 2/803 17/18722 0.16375576841212 0.372484608258591 ZFP36L2/ZFP36L1 2 GO:0061450 trophoblast cell migration 2/803 17/18722 0.16375576841212 0.372484608258591 TIMP1/GJA1 2 GO:0070206 protein trimerization 2/803 17/18722 0.16375576841212 0.372484608258591 COL1A2/STEAP4 2 GO:0070293 renal absorption 2/803 17/18722 0.16375576841212 0.372484608258591 GAS6/GSN 2 GO:0070875 positive regulation of glycogen metabolic process 2/803 17/18722 0.16375576841212 0.372484608258591 IGF2/IRS1 2 GO:0071371 cellular response to gonadotropin stimulus 2/803 17/18722 0.16375576841212 0.372484608258591 GATA6/GCLM 2 GO:0072673 lamellipodium morphogenesis 2/803 17/18722 0.16375576841212 0.372484608258591 PDPN/ENPP2 2 GO:0090036 regulation of protein kinase C signaling 2/803 17/18722 0.16375576841212 0.372484608258591 AKAP12/MYADM 2 GO:0090083 regulation of inclusion body assembly 2/803 17/18722 0.16375576841212 0.372484608258591 HSPA2/CLU 2 GO:0090399 replicative senescence 2/803 17/18722 0.16375576841212 0.372484608258591 PLA2R1/ATM 2 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 2/803 17/18722 0.16375576841212 0.372484608258591 BMP4/NFIB 2 GO:1904262 negative regulation of TORC1 signaling 2/803 17/18722 0.16375576841212 0.372484608258591 SESN3/ATM 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/803 17/18722 0.16375576841212 0.372484608258591 PROM1/YAP1 2 GO:0002448 mast cell mediated immunity 4/803 50/18722 0.165936538068324 0.376535339295475 PTGDS/SPON2/FER/SERPINB9 4 GO:0018023 peptidyl-lysine trimethylation 4/803 50/18722 0.165936538068324 0.376535339295475 KMT2A/ATRX/KMT2E/RTF1 4 GO:0043268 positive regulation of potassium ion transport 4/803 50/18722 0.165936538068324 0.376535339295475 FHL1/FLNA/ATP1B1/WNK1 4 GO:0071709 membrane assembly 4/803 50/18722 0.165936538068324 0.376535339295475 PTPRD/SPTBN1/PTEN/STX2 4 GO:0099054 presynapse assembly 4/803 50/18722 0.165936538068324 0.376535339295475 PTPRD/EFNB2/PTEN/FARP1 4 GO:1901607 alpha-amino acid biosynthetic process 5/803 68/18722 0.166640497486502 0.376535339295475 PLOD2/GLS/SERINC3/SERINC5/OAT 5 GO:0006536 glutamate metabolic process 3/803 33/18722 0.166895928568592 0.376535339295475 GLS/GCLM/OAT 3 GO:0010165 response to X-ray 3/803 33/18722 0.166895928568592 0.376535339295475 CCND2/ATM/NUCKS1 3 GO:0033198 response to ATP 3/803 33/18722 0.166895928568592 0.376535339295475 PTEN/HSP90B1/SLC8A1 3 GO:0036336 dendritic cell migration 3/803 33/18722 0.166895928568592 0.376535339295475 GAS6/EXT1/EPS8 3 GO:0040020 regulation of meiotic nuclear division 3/803 33/18722 0.166895928568592 0.376535339295475 PDE3A/PLCB1/PRKAR1A 3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 3/803 33/18722 0.166895928568592 0.376535339295475 PDGFRA/PDGFRB/IRS1 3 GO:0045648 positive regulation of erythrocyte differentiation 3/803 33/18722 0.166895928568592 0.376535339295475 ACVR2A/FOXO3/STAT3 3 GO:0046320 regulation of fatty acid oxidation 3/803 33/18722 0.166895928568592 0.376535339295475 IRS1/PDK4/TWIST1 3 GO:0046685 response to arsenic-containing substance 3/803 33/18722 0.166895928568592 0.376535339295475 SERPINF1/PTEN/SLC38A2 3 GO:0050901 leukocyte tethering or rolling 3/803 33/18722 0.166895928568592 0.376535339295475 VCAM1/EXT1/ITGB1 3 GO:0050974 detection of mechanical stimulus involved in sensory perception 3/803 33/18722 0.166895928568592 0.376535339295475 COL11A1/SERPINE2/TMEM120A 3 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 3/803 33/18722 0.166895928568592 0.376535339295475 CCND2/PKD1/PKD2 3 GO:0002700 regulation of production of molecular mediator of immune response 10/803 164/18722 0.16760816548592 0.377694508689467 SPON2/CD36/IL1R1/ANGPT1/HLA-A/CD81/B2M/BST2/HLA-F/NDFIP1 10 GO:2001242 regulation of intrinsic apoptotic signaling pathway 10/803 164/18722 0.16760816548592 0.377694508689467 CREB3L1/SNAI2/CLU/NUPR1/SERINC3/PLAUR/SGMS1/SKIL/HSPB1/USP47 10 GO:0051607 defense response to virus 15/803 265/18722 0.167712724075106 0.377694508689467 SPON2/IFITM2/IFITM3/IFITM1/HTRA1/SERINC3/BST2/IFNGR2/DDX17/ZMYND11/BNIP3L/SERINC5/IFI16/PUM2/TSPAN6 15 GO:0140546 defense response to symbiont 15/803 265/18722 0.167712724075106 0.377694508689467 SPON2/IFITM2/IFITM3/IFITM1/HTRA1/SERINC3/BST2/IFNGR2/DDX17/ZMYND11/BNIP3L/SERINC5/IFI16/PUM2/TSPAN6 15 GO:0051053 negative regulation of DNA metabolic process 8/803 125/18722 0.168745261844808 0.379676839150817 GJA1/TWIST1/BMPR2/KMT2A/RNF169/TERF1/ATM/NDFIP1 8 GO:0071621 granulocyte chemotaxis 8/803 125/18722 0.168745261844808 0.379676839150817 RARRES2/SLIT2/CSF1/ITGA1/THBS1/CMKLR1/MDK/DPP4 8 GO:0044070 regulation of anion transport 6/803 87/18722 0.169915201754569 0.381964470671002 STC1/CES1/PRNP/ITGB1/PLA2R1/PRKAA1 6 GO:1903578 regulation of ATP metabolic process 6/803 87/18722 0.169915201754569 0.381964470671002 TSPO/COX7A1/NUPR1/PID1/STAT3/PRKAA1 6 GO:0006766 vitamin metabolic process 7/803 106/18722 0.170185194795161 0.382226748310214 RBP1/NNMT/CRABP1/SNAI2/RDH10/PLTP/SLC19A3 7 GO:1903707 negative regulation of hemopoiesis 7/803 106/18722 0.170185194795161 0.382226748310214 BMP4/TMEM176A/TMEM176B/MDK/PIK3R1/FBN1/GPR137B 7 GO:0042176 regulation of protein catabolic process 21/803 391/18722 0.171926215261258 0.385963128902581 SERPINE2/GPC3/APOE/TIMP1/GJA1/PRICKLE1/FLNA/LAPTM4B/CD81/PTEN/TIMP3/PKD1/LRP1/CLU/NUPR1/TIMP2/DAB2/MSN/HECTD1/CTSA/NDFIP1 21 GO:0031060 regulation of histone methylation 5/803 69/18722 0.173790951137698 0.38992257111485 NNMT/KMT2A/ATRX/KMT2E/RTF1 5 GO:0031929 TOR signaling 8/803 126/18722 0.173924548367314 0.38992257111485 GAS6/EIF4EBP1/SESN3/GPR137B/PRKAA1/EIF4EBP2/CCDC88A/ATM 8 GO:2001235 positive regulation of apoptotic signaling pathway 8/803 126/18722 0.173924548367314 0.38992257111485 SRPX/THBS1/PTEN/TIMP3/NUPR1/SERINC3/SKIL/LTBR 8 GO:0048013 ephrin receptor signaling pathway 4/803 51/18722 0.17438994546964 0.390614675701539 MMP2/EPHA3/CHN1/EFNB2 4 GO:0065002 intracellular protein transmembrane transport 4/803 51/18722 0.17438994546964 0.390614675701539 TRAM1/SEC61A1/TRAM2/SEC62 4 GO:0032412 regulation of ion transmembrane transporter activity 15/803 267/18722 0.174690912669395 0.391113107575035 FHL1/FXYD1/HSPA2/ATP1B1/PTEN/CAMK2D/PKD2/PRNP/AHNAK/ITGB1/IFNGR2/WNK1/DAPK1/STOM/ACTN4 15 GO:0046486 glycerolipid metabolic process 21/803 392/18722 0.174808682645462 0.39120111834393 ENPP2/PLA2G2A/TNXB/PDGFRB/APOE/PTEN/SERINC1/PIK3R1/SOCS2/CISH/LPGAT1/AGPAT2/PLCB1/LPCAT2/SOCS3/SERINC3/LPIN1/CAPN2/SERINC5/ATM/IPMK 21 GO:0070098 chemokine-mediated signaling pathway 6/803 88/18722 0.176236870452786 0.394220294337188 SLIT2/SLIT3/ACKR1/CMKLR1/ROBO1/WNK1 6 GO:0010661 positive regulation of muscle cell apoptotic process 3/803 34/18722 0.177602536991069 0.39514928194547 PTEN/CAMK2D/CAPN2 3 GO:0042573 retinoic acid metabolic process 3/803 34/18722 0.177602536991069 0.39514928194547 RBP1/CRABP1/RDH10 3 GO:0043276 anoikis 3/803 34/18722 0.177602536991069 0.39514928194547 SNAI2/PDK4/ITGB1 3 GO:0048536 spleen development 3/803 34/18722 0.177602536991069 0.39514928194547 TCF21/PITX2/ABL1 3 GO:0048854 brain morphogenesis 3/803 34/18722 0.177602536991069 0.39514928194547 PTEN/FOXO3/SOS1 3 GO:0070884 regulation of calcineurin-NFAT signaling cascade 3/803 34/18722 0.177602536991069 0.39514928194547 LMCD1/NFAT5/PRNP 3 GO:1904893 negative regulation of receptor signaling pathway via STAT 3/803 34/18722 0.177602536991069 0.39514928194547 PTPRD/SOCS2/SOCS3 3 GO:2000352 negative regulation of endothelial cell apoptotic process 3/803 34/18722 0.177602536991069 0.39514928194547 GAS6/ANGPT1/ABL1 3 GO:0001946 lymphangiogenesis 2/803 18/18722 0.179267484107632 0.39514928194547 PDPN/BMPR2 2 GO:0002643 regulation of tolerance induction 2/803 18/18722 0.179267484107632 0.39514928194547 HLA-B/TGFBR2 2 GO:0003417 growth plate cartilage development 2/803 18/18722 0.179267484107632 0.39514928194547 STC1/TGFBR2 2 GO:0006957 complement activation, alternative pathway 2/803 18/18722 0.179267484107632 0.39514928194547 C7/CFD 2 GO:0019184 nonribosomal peptide biosynthetic process 2/803 18/18722 0.179267484107632 0.39514928194547 BDH2/GCLM 2 GO:0030728 ovulation 2/803 18/18722 0.179267484107632 0.39514928194547 ADAMTS1/FOXO3 2 GO:0031000 response to caffeine 2/803 18/18722 0.179267484107632 0.39514928194547 PRKAA1/SLC8A1 2 GO:0033189 response to vitamin A 2/803 18/18722 0.179267484107632 0.39514928194547 MAP1B/GATA4 2 GO:0034134 toll-like receptor 2 signaling pathway 2/803 18/18722 0.179267484107632 0.39514928194547 MFHAS1/PJA2 2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 2/803 18/18722 0.179267484107632 0.39514928194547 IL1R1/CD81 2 GO:0036507 protein demannosylation 2/803 18/18722 0.179267484107632 0.39514928194547 MAN1A1/AMFR 2 GO:0036508 protein alpha-1,2-demannosylation 2/803 18/18722 0.179267484107632 0.39514928194547 MAN1A1/AMFR 2 GO:0044872 lipoprotein localization 2/803 18/18722 0.179267484107632 0.39514928194547 CD36/LRP1 2 GO:0048268 clathrin coat assembly 2/803 18/18722 0.179267484107632 0.39514928194547 AP2B1/CLTC 2 GO:0048486 parasympathetic nervous system development 2/803 18/18722 0.179267484107632 0.39514928194547 NRP2/NAV2 2 GO:0048535 lymph node development 2/803 18/18722 0.179267484107632 0.39514928194547 PDPN/CD248 2 GO:0048643 positive regulation of skeletal muscle tissue development 2/803 18/18722 0.179267484107632 0.39514928194547 IGF2/PRKAA1 2 GO:0071071 regulation of phospholipid biosynthetic process 2/803 18/18722 0.179267484107632 0.39514928194547 LPIN1/CAPN2 2 GO:0071786 endoplasmic reticulum tubular network organization 2/803 18/18722 0.179267484107632 0.39514928194547 RTN4/ATL3 2 GO:0072189 ureter development 2/803 18/18722 0.179267484107632 0.39514928194547 BMP4/NFIA 2 GO:0097107 postsynaptic density assembly 2/803 18/18722 0.179267484107632 0.39514928194547 PTPRD/PTEN 2 GO:0097709 connective tissue replacement 2/803 18/18722 0.179267484107632 0.39514928194547 TIMP1/ROCK2 2 GO:1902001 fatty acid transmembrane transport 2/803 18/18722 0.179267484107632 0.39514928194547 CD36/THBS1 2 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 2/803 18/18722 0.179267484107632 0.39514928194547 DCN/ADGRA2 2 GO:2000641 regulation of early endosome to late endosome transport 2/803 18/18722 0.179267484107632 0.39514928194547 DAB2/MSN 2 GO:1902850 microtubule cytoskeleton organization involved in mitosis 9/803 147/18722 0.180753742597624 0.398249297654331 GJA1/SPRY1/FLNA/PKD1/GNAI1/ITGB1/MAP9/SBDS/CLTC 9 GO:0098659 inorganic cation import across plasma membrane 7/803 108/18722 0.181639038024942 0.39984646516219 ATP1B1/SLC9A9/SLC39A6/PRNP/WNK1/SLC39A4/SLC8A1 7 GO:0099587 inorganic ion import across plasma membrane 7/803 108/18722 0.181639038024942 0.39984646516219 ATP1B1/SLC9A9/SLC39A6/PRNP/WNK1/SLC39A4/SLC8A1 7 GO:0046330 positive regulation of JNK cascade 6/803 89/18722 0.182652688410999 0.401723116196402 MFHAS1/PLCB1/TAOK1/PJA2/RB1CC1/LTBR 6 GO:1900407 regulation of cellular response to oxidative stress 6/803 89/18722 0.182652688410999 0.401723116196402 HGF/FBLN5/GATA4/CD36/FOXO3/HSPB1 6 GO:0035176 social behavior 4/803 52/18722 0.18298732928109 0.402104373642802 PTEN/EXT1/EIF4EBP2/ATXN1 4 GO:1903426 regulation of reactive oxygen species biosynthetic process 4/803 52/18722 0.18298732928109 0.402104373642802 CD36/SLC5A3/FOXO3/STAT3 4 GO:1901215 negative regulation of neuron death 12/803 208/18722 0.183893014797837 0.403732829770517 CSF1/APOE/ANGPT1/SERPINF1/GPNMB/MDK/LRP1/AXL/AP2B1/HLA-F/STAT3/GCLM 12 GO:0006066 alcohol metabolic process 19/803 353/18722 0.183971317536826 0.403732829770517 BMP5/DKK3/PLPP1/APOE/CES1/PLPP3/RDH10/PTEN/APOL1/H6PD/SLC5A3/CYB5R3/OSBPL1A/PRKAA1/VLDLR/NPC2/ABCA5/MBTPS1/IPMK 19 GO:0051480 regulation of cytosolic calcium ion concentration 19/803 353/18722 0.183971317536826 0.403732829770517 PDGFRA/THY1/PTGFR/CD36/EDNRB/LPAR1/GJA1/CMKLR1/PTGER2/CAMK2D/PKD1/LRP1/PKD2/LRP6/PRNP/ABL1/TPCN1/NPTN/SLC8A1 19 GO:0048839 inner ear development 11/803 188/18722 0.185118843797837 0.406072395589976 CTHRC1/CYTL1/COL11A1/PDGFRB/HOXA13/BMP4/SPARC/MAF/PTK7/JAG1/CEP290 11 GO:0010212 response to ionizing radiation 9/803 148/18722 0.185698934772936 0.406482947376093 CCND2/VCAM1/CRYAB/YAP1/PRKAA1/IFI16/ATM/NUCKS1/CLOCK 9 GO:0097530 granulocyte migration 9/803 148/18722 0.185698934772936 0.406482947376093 RARRES2/SLIT2/CSF1/ITGA1/THBS1/IL1R1/CMKLR1/MDK/DPP4 9 GO:1903900 regulation of viral life cycle 9/803 148/18722 0.185698934772936 0.406482947376093 IFITM2/IFITM3/LGALS1/IFITM1/AXL/BST2/FAM111A/IFI16/GSN 9 GO:0016482 cytosolic transport 10/803 168/18722 0.185795153844789 0.406482947376093 CES1/FLNA/MON2/PREPL/TMEM87A/DAB2/EVI5/MSN/SORT1/CLTC 10 GO:0099173 postsynapse organization 10/803 168/18722 0.185795153844789 0.406482947376093 PTPRD/APOE/PTEN/PDLIM5/NRP2/PRNP/NDRG1/ABI2/WASL/FARP1 10 GO:2000241 regulation of reproductive process 10/803 168/18722 0.185795153844789 0.406482947376093 PDE3A/BMP4/EDNRB/TIMP1/GJA1/SERPINF1/PLCB1/NUPR1/CDC25B/PRKAR1A 10 GO:0072078 nephron tubule morphogenesis 5/803 71/18722 0.188433106341164 0.410759519652675 TCF21/BMP4/GPC3/PKD1/PKD2 5 GO:0015695 organic cation transport 3/803 35/18722 0.188491331922447 0.410759519652675 SLC22A3/SLC19A3/SLC38A2 3 GO:0018149 peptide cross-linking 3/803 35/18722 0.188491331922447 0.410759519652675 DCN/COL3A1/THBS1 3 GO:0032814 regulation of natural killer cell activation 3/803 35/18722 0.188491331922447 0.410759519652675 GAS6/AXL/HLA-F 3 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 3/803 35/18722 0.188491331922447 0.410759519652675 KANK2/YAP1/STRN3 3 GO:0033280 response to vitamin D 3/803 35/18722 0.188491331922447 0.410759519652675 STC1/SNAI2/KANK2 3 GO:0040001 establishment of mitotic spindle localization 3/803 35/18722 0.188491331922447 0.410759519652675 GJA1/SPRY1/ITGB1 3 GO:0042462 eye photoreceptor cell development 3/803 35/18722 0.188491331922447 0.410759519652675 THY1/TUG1/CEP290 3 GO:0106056 regulation of calcineurin-mediated signaling 3/803 35/18722 0.188491331922447 0.410759519652675 LMCD1/NFAT5/PRNP 3 GO:0032392 DNA geometric change 6/803 90/18722 0.189159637864567 0.411676104056191 CHD9/PURA/ATRX/SETX/RECQL/NAV2 6 GO:0034644 cellular response to UV 6/803 90/18722 0.189159637864567 0.411676104056191 MMP2/MFAP4/TIMP1/PTPRK/PIK3R1/USP47 6 GO:0035304 regulation of protein dephosphorylation 6/803 90/18722 0.189159637864567 0.411676104056191 PDGFRB/ITGA1/MFHAS1/ROCK2/DLC1/HSP90B1 6 GO:0032368 regulation of lipid transport 9/803 149/18722 0.190703232830823 0.414854414875429 ABCA8/THBS1/APOE/CES1/LRP1/PLTP/TSPO/PLA2R1/ABCA5 9 GO:0099172 presynapse organization 4/803 53/18722 0.191720623988206 0.416885752815174 PTPRD/EFNB2/PTEN/FARP1 4 GO:0048259 regulation of receptor-mediated endocytosis 7/803 110/18722 0.193405273834461 0.419599310201342 VTN/ANGPT1/CD63/B2M/CLU/DAB2/WASL 7 GO:0045732 positive regulation of protein catabolic process 13/803 231/18722 0.194224919830939 0.419599310201342 GPC3/APOE/GJA1/PRICKLE1/CD81/PTEN/LRP1/CLU/NUPR1/DAB2/MSN/HECTD1/NDFIP1 13 GO:0006670 sphingosine metabolic process 2/803 19/18722 0.194988287552449 0.419599310201342 PLPP1/PLPP3 2 GO:0010738 regulation of protein kinase A signaling 2/803 19/18722 0.194988287552449 0.419599310201342 AKAP12/PJA2 2 GO:0010829 negative regulation of glucose transmembrane transport 2/803 19/18722 0.194988287552449 0.419599310201342 ENPP1/PID1 2 GO:0010885 regulation of cholesterol storage 2/803 19/18722 0.194988287552449 0.419599310201342 CD36/CES1 2 GO:0031290 retinal ganglion cell axon guidance 2/803 19/18722 0.194988287552449 0.419599310201342 SLIT2/ALCAM 2 GO:0032695 negative regulation of interleukin-12 production 2/803 19/18722 0.194988287552449 0.419599310201342 THBS1/CMKLR1 2 GO:0033194 response to hydroperoxide 2/803 19/18722 0.194988287552449 0.419599310201342 CD36/DAPK1 2 GO:0035313 wound healing, spreading of epidermal cells 2/803 19/18722 0.194988287552449 0.419599310201342 COL5A1/PTEN 2 GO:0035728 response to hepatocyte growth factor 2/803 19/18722 0.194988287552449 0.419599310201342 HGF/GCLM 2 GO:0042474 middle ear morphogenesis 2/803 19/18722 0.194988287552449 0.419599310201342 OSR2/TSHZ1 2 GO:0044827 modulation by host of viral genome replication 2/803 19/18722 0.194988287552449 0.419599310201342 STOM/NUCKS1 2 GO:0045019 negative regulation of nitric oxide biosynthetic process 2/803 19/18722 0.194988287552449 0.419599310201342 TSPO/ROCK2 2 GO:0045780 positive regulation of bone resorption 2/803 19/18722 0.194988287552449 0.419599310201342 PRKCA/LTBP3 2 GO:0045947 negative regulation of translational initiation 2/803 19/18722 0.194988287552449 0.419599310201342 EIF4EBP1/EIF4EBP2 2 GO:0046782 regulation of viral transcription 2/803 19/18722 0.194988287552449 0.419599310201342 IFITM3/RSF1 2 GO:0046794 transport of virus 2/803 19/18722 0.194988287552449 0.419599310201342 BST2/TPCN1 2 GO:0086014 atrial cardiac muscle cell action potential 2/803 19/18722 0.194988287552449 0.419599310201342 GJA1/FLNA 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/803 19/18722 0.194988287552449 0.419599310201342 GJA1/FLNA 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/803 19/18722 0.194988287552449 0.419599310201342 GJA1/FLNA 2 GO:1901739 regulation of myoblast fusion 2/803 19/18722 0.194988287552449 0.419599310201342 EHD2/CAPN2 2 GO:1904406 negative regulation of nitric oxide metabolic process 2/803 19/18722 0.194988287552449 0.419599310201342 TSPO/ROCK2 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/803 19/18722 0.194988287552449 0.419599310201342 DAB2/WASL 2 GO:0043467 regulation of generation of precursor metabolites and energy 8/803 130/18722 0.19532842348713 0.420149922134093 ENPP1/IGF2/IRS1/COX7A1/NUPR1/STAT3/PRKAA1/IFNAR1 8 GO:0005977 glycogen metabolic process 5/803 72/18722 0.195915444834743 0.421230878803806 ENPP1/IL6ST/IGF2/IRS1/RB1CC1 5 GO:0015718 monocarboxylic acid transport 7/803 111/18722 0.199400129703199 0.42737740406643 PLA2G2A/SLC22A3/CD36/CES1/SLC16A7/PLA2R1/PRKAA1 7 GO:0008207 C21-steroid hormone metabolic process 3/803 36/18722 0.199545647145337 0.42737740406643 BMP5/DKK3/TSPO 3 GO:0036314 response to sterol 3/803 36/18722 0.199545647145337 0.42737740406643 CES1/LRP6/TGFBR2 3 GO:0042092 type 2 immune response 3/803 36/18722 0.199545647145337 0.42737740406643 ECM1/CD81/NDFIP1 3 GO:0043949 regulation of cAMP-mediated signaling 3/803 36/18722 0.199545647145337 0.42737740406643 PDE3A/PDE3B/GNAI1 3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 3/803 36/18722 0.199545647145337 0.42737740406643 PLAUR/CCDC88A/SOS1 3 GO:0060251 regulation of glial cell proliferation 3/803 36/18722 0.199545647145337 0.42737740406643 TSPO/SKI/CERS2 3 GO:0070873 regulation of glycogen metabolic process 3/803 36/18722 0.199545647145337 0.42737740406643 ENPP1/IGF2/IRS1 3 GO:0090313 regulation of protein targeting to membrane 3/803 36/18722 0.199545647145337 0.42737740406643 PRNP/STOM/MYO1C 3 GO:0051048 negative regulation of secretion 10/803 171/18722 0.199994716261621 0.42815528350384 SPX/STXBP6/APOE/GJA1/IRS1/TNFRSF1A/HLA-F/PLA2R1/WNK1/MAP4K4 10 GO:0030520 intracellular estrogen receptor signaling pathway 4/803 54/18722 0.200581720726173 0.42885954525759 KANK2/YAP1/DDX17/STRN3 4 GO:0051703 biological process involved in intraspecies interaction between organisms 4/803 54/18722 0.200581720726173 0.42885954525759 PTEN/EXT1/EIF4EBP2/ATXN1 4 GO:0070839 metal ion export 4/803 54/18722 0.200581720726173 0.42885954525759 FXYD1/ATP1B1/SLC40A1/SLC8A1 4 GO:0043535 regulation of blood vessel endothelial cell migration 9/803 151/18722 0.200884125724456 0.429263147771875 THBS1/APOE/FGFR1/ANGPT1/PRKCA/SPRED1/KLF4/ABL1/HSPB1 9 GO:0006816 calcium ion transport 22/803 422/18722 0.200942676875162 0.429263147771875 STC1/THY1/PDGFRB/GAS6/MYLK/GJA1/BIN1/RAMP1/HSPA2/ATP1B1/CASK/CAMK2D/PKD1/PKD2/TSPO/SEC61A1/PRNP/AHNAK/SESTD1/ABL1/TPCN1/SLC8A1 22 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 13/803 233/18722 0.202391436081854 0.432079885521303 PTGFR/VIPR2/PALM/ADCY3/AKAP12/LPAR1/PRKCA/PTGER2/ADGRD1/FLNA/RAMP1/GNAI1/AKAP13 13 GO:0070509 calcium ion import 6/803 92/18722 0.202434539225384 0.432079885521303 STC1/PDGFRB/CASK/PKD2/PRNP/SLC8A1 6 GO:0006073 cellular glucan metabolic process 5/803 73/18722 0.203498932367223 0.433238973861218 ENPP1/IL6ST/IGF2/IRS1/RB1CC1 5 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 5/803 73/18722 0.203498932367223 0.433238973861218 ITGA1/PLAUR/FER/CCDC88A/SOS1 5 GO:0044042 glucan metabolic process 5/803 73/18722 0.203498932367223 0.433238973861218 ENPP1/IL6ST/IGF2/IRS1/RB1CC1 5 GO:0072088 nephron epithelium morphogenesis 5/803 73/18722 0.203498932367223 0.433238973861218 TCF21/BMP4/GPC3/PKD1/PKD2 5 GO:0099518 vesicle cytoskeletal trafficking 5/803 73/18722 0.203498932367223 0.433238973861218 MYO1B/MYO1E/WASL/MYO1C/ACTN4 5 GO:1904427 positive regulation of calcium ion transmembrane transport 5/803 73/18722 0.203498932367223 0.433238973861218 THY1/HSPA2/ATP1B1/PKD2/ABL1 5 GO:0009101 glycoprotein biosynthetic process 17/803 317/18722 0.204170664404681 0.434483539360537 CYTL1/GXYLT2/CSGALNACT1/DSEL/MAN1A1/CSGALNACT2/SLC2A10/RAMP1/EXT1/PGM3/UGDH/PLCB1/BMPR2/GALNT1/TMEM59/CHPF2/DPY19L4 17 GO:0002821 positive regulation of adaptive immune response 7/803 112/18722 0.205466494787071 0.436681987642087 IL1R1/IL6ST/HLA-B/HLA-A/CD81/B2M/HLA-F 7 GO:0032609 interferon-gamma production 7/803 112/18722 0.205466494787071 0.436681987642087 GAS6/IL1R1/HLA-A/AXL/PRNP/ABL1/BTN3A2 7 GO:0032649 regulation of interferon-gamma production 7/803 112/18722 0.205466494787071 0.436681987642087 GAS6/IL1R1/HLA-A/AXL/PRNP/ABL1/BTN3A2 7 GO:0008643 carbohydrate transport 9/803 152/18722 0.206058130548339 0.437566370917385 ENPP1/GPC3/SLC2A10/IRS1/PIK3R1/RHOQ/SLC5A3/PID1/SORT1 9 GO:0031056 regulation of histone modification 9/803 152/18722 0.206058130548339 0.437566370917385 NNMT/IGF2/CAMK2D/TWIST1/KMT2A/ATRX/SKI/KMT2E/RTF1 9 GO:0007569 cell aging 8/803 132/18722 0.206420019563194 0.438148240758656 TBX2/PTEN/B2M/TWIST1/ABL1/PLA2R1/ZMIZ1/ATM 8 GO:0006790 sulfur compound metabolic process 18/803 339/18722 0.207293261179263 0.439814553293534 DCN/ENPP1/ELOVL2/TPST1/PAPSS2/CSGALNACT1/ANGPT1/DSEL/CSGALNACT2/PDK4/EXT1/UGDH/SLC19A3/GLO1/CHPF2/GSTM3/GCLM/PAPSS1 18 GO:0090398 cellular senescence 6/803 93/18722 0.209196152405732 0.441026306818111 TBX2/B2M/TWIST1/ABL1/PLA2R1/ATM 6 GO:0106027 neuron projection organization 6/803 93/18722 0.209196152405732 0.441026306818111 APOE/PTEN/PDLIM5/PRNP/ABI2/WASL 6 GO:1901992 positive regulation of mitotic cell cycle phase transition 6/803 93/18722 0.209196152405732 0.441026306818111 CCND2/ADAMTS1/HSPA2/PLCB1/CDC25B/KMT2E 6 GO:0098900 regulation of action potential 4/803 55/18722 0.209562489569344 0.441026306818111 CD36/BIN1/FLNA/CAMK2D 4 GO:0006623 protein targeting to vacuole 3/803 37/18722 0.210749110818608 0.441026306818111 CLU/SCARB2/SORT1 3 GO:0007340 acrosome reaction 3/803 37/18722 0.210749110818608 0.441026306818111 ADCY3/PLCB1/STX2 3 GO:0033120 positive regulation of RNA splicing 3/803 37/18722 0.210749110818608 0.441026306818111 PIK3R1/SLC38A2/SETX 3 GO:0043403 skeletal muscle tissue regeneration 3/803 37/18722 0.210749110818608 0.441026306818111 CD9/CD81/TGFBR2 3 GO:0043687 post-translational protein modification 3/803 37/18722 0.210749110818608 0.441026306818111 FAM20C/CRTAP/ICMT 3 GO:0046473 phosphatidic acid metabolic process 3/803 37/18722 0.210749110818608 0.441026306818111 PLA2G2A/AGPAT2/LPIN1 3 GO:0051294 establishment of spindle orientation 3/803 37/18722 0.210749110818608 0.441026306818111 GJA1/SPRY1/ITGB1 3 GO:0071542 dopaminergic neuron differentiation 3/803 37/18722 0.210749110818608 0.441026306818111 WNT2/RSPO2/LRP6 3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 2/803 20/18722 0.210871784086317 0.441026306818111 CDK18/BACH1 2 GO:0001832 blastocyst growth 2/803 20/18722 0.210871784086317 0.441026306818111 SBDS/RTF1 2 GO:0006525 arginine metabolic process 2/803 20/18722 0.210871784086317 0.441026306818111 DDAH2/OAT 2 GO:0006590 thyroid hormone generation 2/803 20/18722 0.210871784086317 0.441026306818111 SLC16A10/CTSK 2 GO:0007194 negative regulation of adenylate cyclase activity 2/803 20/18722 0.210871784086317 0.441026306818111 PALM/EDNRB 2 GO:0009110 vitamin biosynthetic process 2/803 20/18722 0.210871784086317 0.441026306818111 SNAI2/PLTP 2 GO:0010042 response to manganese ion 2/803 20/18722 0.210871784086317 0.441026306818111 FIBIN/TSPO 2 GO:0032332 positive regulation of chondrocyte differentiation 2/803 20/18722 0.210871784086317 0.441026306818111 SOX5/GDF6 2 GO:0032495 response to muramyl dipeptide 2/803 20/18722 0.210871784086317 0.441026306818111 VIM/JAG1 2 GO:0043586 tongue development 2/803 20/18722 0.210871784086317 0.441026306818111 HAND2/BNC2 2 GO:0045844 positive regulation of striated muscle tissue development 2/803 20/18722 0.210871784086317 0.441026306818111 IGF2/PRKAA1 2 GO:0048636 positive regulation of muscle organ development 2/803 20/18722 0.210871784086317 0.441026306818111 IGF2/PRKAA1 2 GO:0051004 regulation of lipoprotein lipase activity 2/803 20/18722 0.210871784086317 0.441026306818111 PCSK6/SORT1 2 GO:0060231 mesenchymal to epithelial transition 2/803 20/18722 0.210871784086317 0.441026306818111 BMP4/BASP1 2 GO:0071397 cellular response to cholesterol 2/803 20/18722 0.210871784086317 0.441026306818111 CES1/LRP6 2 GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/803 20/18722 0.210871784086317 0.441026306818111 LRP1/KLF4 2 GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/803 20/18722 0.210871784086317 0.441026306818111 HGF/CLU 2 GO:0097150 neuronal stem cell population maintenance 2/803 20/18722 0.210871784086317 0.441026306818111 JAG1/FOXO3 2 GO:0098543 detection of other organism 2/803 20/18722 0.210871784086317 0.441026306818111 HLA-B/HLA-A 2 GO:1902004 positive regulation of amyloid-beta formation 2/803 20/18722 0.210871784086317 0.441026306818111 CLU/ROCK2 2 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/803 20/18722 0.210871784086317 0.441026306818111 LRP1/KLF4 2 GO:2000479 regulation of cAMP-dependent protein kinase activity 2/803 20/18722 0.210871784086317 0.441026306818111 PRKAR1A/PKIG 2 GO:0007040 lysosome organization 5/803 74/18722 0.211178729491821 0.441298049139237 SRPX/LAPTM4B/TMEM106B/SCARB2/MBTPS1 5 GO:0080171 lytic vacuole organization 5/803 74/18722 0.211178729491821 0.441298049139237 SRPX/LAPTM4B/TMEM106B/SCARB2/MBTPS1 5 GO:0034765 regulation of ion transmembrane transport 25/803 491/18722 0.21476180780048 0.448597559150897 FHL1/THY1/FXYD1/KCNMA1/BIN1/FLNA/HSPA2/ATP1B1/PTEN/CD63/CAMK2D/PKD2/PRNP/AHNAK/TWIST1/SESTD1/ITGB1/IFNGR2/ABL1/WNK1/TPCN1/DAPK1/STOM/SLC8A1/ACTN4 25 GO:0030217 T cell differentiation 14/803 257/18722 0.215441538222076 0.449828940358153 BMP4/TMEM98/MDK/B2M/PTPRK/TGFBR2/ZFP36L2/ZFP36L1/ABL1/STAT3/ZMIZ1/SP3/PKNOX1/SOS1 14 GO:0010389 regulation of G2/M transition of mitotic cell cycle 6/803 94/18722 0.216036231302499 0.450881812170055 FHL1/HSPA2/CDC25B/TAOK1/ATM/USP47 6 GO:0007041 lysosomal transport 7/803 114/18722 0.217804544099325 0.45438219953106 BIN1/TMEM106B/LRP1/CLU/SCARB2/IGF2R/SORT1 7 GO:0001658 branching involved in ureteric bud morphogenesis 4/803 56/18722 0.218654800530417 0.455013704275734 TCF21/BMP4/GPC3/PKD2 4 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 4/803 56/18722 0.218654800530417 0.455013704275734 HLA-B/HLA-A/B2M/HLA-F 4 GO:0010332 response to gamma radiation 4/803 56/18722 0.218654800530417 0.455013704275734 CRYAB/YAP1/PRKAA1/ATM 4 GO:0010518 positive regulation of phospholipase activity 4/803 56/18722 0.218654800530417 0.455013704275734 PDGFRA/PDGFRB/LPAR1/FGFR1 4 GO:0043470 regulation of carbohydrate catabolic process 4/803 56/18722 0.218654800530417 0.455013704275734 NUPR1/SCARB2/STAT3/PRKAA1 4 GO:0051653 spindle localization 4/803 56/18722 0.218654800530417 0.455013704275734 GJA1/SPRY1/ITGB1/WASL 4 GO:0033077 T cell differentiation in thymus 5/803 75/18722 0.218949952772665 0.455437824165418 BMP4/B2M/ZFP36L2/ZFP36L1/SOS1 5 GO:0051147 regulation of muscle cell differentiation 9/803 155/18722 0.221898219161392 0.461378032001126 EFEMP2/PRDM6/BMP4/EFNB2/IGF2/PIEZO1/ENG/BMPR2/FRS2 9 GO:0006882 cellular zinc ion homeostasis 3/803 38/18722 0.222085684951364 0.46138301048646 SLC39A13/SLC39A6/SLC39A4 3 GO:2000279 negative regulation of DNA biosynthetic process 3/803 38/18722 0.222085684951364 0.46138301048646 GJA1/BMPR2/TERF1 3 GO:0050727 regulation of inflammatory response 20/803 386/18722 0.222369228407732 0.461779663823802 HGF/PLA2G2A/WFDC1/EDNRB/APOE/OSMR/IL1R1/IL6ST/MFHAS1/CD81/SERPINF1/MDK/SOCS3/NUPR1/TNFRSF1A/KLF4/ASH1L/METRNL/NDFIP1/CLOCK 20 GO:0006942 regulation of striated muscle contraction 6/803 95/18722 0.222951489956245 0.462796057003263 STC1/GATA4/BIN1/ATP1B1/CAMK2D/SLC8A1 6 GO:0021700 developmental maturation 15/803 280/18722 0.223415084757918 0.463565381857253 MMP2/PDE3A/MAP1B/PALM/EDNRB/NFIA/PTEN/NRCAM/EXT1/CD63/AXL/EPAS1/CDC25B/FOXO3/CLSTN1 15 GO:0042471 ear morphogenesis 7/803 115/18722 0.224071527700991 0.464558346430906 CTHRC1/COL11A1/OSR2/TSHZ1/PTK7/TWIST1/CEP290 7 GO:0008652 cellular amino acid biosynthetic process 5/803 76/18722 0.22680768491965 0.464558346430906 PLOD2/GLS/SERINC3/SERINC5/OAT 5 GO:0021536 diencephalon development 5/803 76/18722 0.22680768491965 0.464558346430906 PITX2/PITX1/BMP4/NRP2/NCOA1 5 GO:0032720 negative regulation of tumor necrosis factor production 5/803 76/18722 0.22680768491965 0.464558346430906 GAS6/GPNMB/AXL/TSPO/TWIST1 5 GO:0045685 regulation of glial cell differentiation 5/803 76/18722 0.22680768491965 0.464558346430906 SERPINE2/TMEM98/BIN1/IL6ST/MDK 5 GO:0140115 export across plasma membrane 5/803 76/18722 0.22680768491965 0.464558346430906 FXYD1/GJA1/ATP1B1/SLC40A1/SLC8A1 5 GO:0002689 negative regulation of leukocyte chemotaxis 2/803 21/18722 0.226875165174339 0.464558346430906 SLIT2/DPP4 2 GO:0009070 serine family amino acid biosynthetic process 2/803 21/18722 0.226875165174339 0.464558346430906 SERINC3/SERINC5 2 GO:0010878 cholesterol storage 2/803 21/18722 0.226875165174339 0.464558346430906 CD36/CES1 2 GO:0022010 central nervous system myelination 2/803 21/18722 0.226875165174339 0.464558346430906 PTEN/CLU 2 GO:0030449 regulation of complement activation 2/803 21/18722 0.226875165174339 0.464558346430906 SERPING1/A2M 2 GO:0031998 regulation of fatty acid beta-oxidation 2/803 21/18722 0.226875165174339 0.464558346430906 IRS1/TWIST1 2 GO:0032288 myelin assembly 2/803 21/18722 0.226875165174339 0.464558346430906 PMP22/CD9 2 GO:0032291 axon ensheathment in central nervous system 2/803 21/18722 0.226875165174339 0.464558346430906 PTEN/CLU 2 GO:0032516 positive regulation of phosphoprotein phosphatase activity 2/803 21/18722 0.226875165174339 0.464558346430906 PDGFRB/ITGA1 2 GO:0035813 regulation of renal sodium excretion 2/803 21/18722 0.226875165174339 0.464558346430906 SPX/EDNRB 2 GO:0043576 regulation of respiratory gaseous exchange 2/803 21/18722 0.226875165174339 0.464558346430906 GLS/SLC5A3 2 GO:0044766 multi-organism transport 2/803 21/18722 0.226875165174339 0.464558346430906 BST2/TPCN1 2 GO:0045655 regulation of monocyte differentiation 2/803 21/18722 0.226875165174339 0.464558346430906 CSF1/ZFP36L1 2 GO:0046519 sphingoid metabolic process 2/803 21/18722 0.226875165174339 0.464558346430906 PLPP1/PLPP3 2 GO:0048485 sympathetic nervous system development 2/803 21/18722 0.226875165174339 0.464558346430906 HAND2/NRP2 2 GO:0051152 positive regulation of smooth muscle cell differentiation 2/803 21/18722 0.226875165174339 0.464558346430906 EFEMP2/ENG 2 GO:0060445 branching involved in salivary gland morphogenesis 2/803 21/18722 0.226875165174339 0.464558346430906 HGF/FGF7 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/803 21/18722 0.226875165174339 0.464558346430906 SPON2/CD36 2 GO:0070584 mitochondrion morphogenesis 2/803 21/18722 0.226875165174339 0.464558346430906 PLEC/PID1 2 GO:0071605 monocyte chemotactic protein-1 production 2/803 21/18722 0.226875165174339 0.464558346430906 APOD/TWIST1 2 GO:0071637 regulation of monocyte chemotactic protein-1 production 2/803 21/18722 0.226875165174339 0.464558346430906 APOD/TWIST1 2 GO:0097062 dendritic spine maintenance 2/803 21/18722 0.226875165174339 0.464558346430906 APOE/PRNP 2 GO:0098698 postsynaptic specialization assembly 2/803 21/18722 0.226875165174339 0.464558346430906 PTPRD/PTEN 2 GO:0098719 sodium ion import across plasma membrane 2/803 21/18722 0.226875165174339 0.464558346430906 SLC9A9/SLC8A1 2 GO:1901863 positive regulation of muscle tissue development 2/803 21/18722 0.226875165174339 0.464558346430906 IGF2/PRKAA1 2 GO:1902579 multi-organism localization 2/803 21/18722 0.226875165174339 0.464558346430906 BST2/TPCN1 2 GO:0009267 cellular response to starvation 9/803 156/18722 0.22727962648071 0.465195491639089 GAS6/PDK4/SESN3/BMPR2/SLC38A2/SLC39A4/FOXO3/PRKAA1/IFI16 9 GO:0006470 protein dephosphorylation 15/803 281/18722 0.227388025530196 0.465226382968222 PDGFRB/PTPRD/ITGA1/MFHAS1/PTEN/PPM1K/PTPRK/ROCK2/CDC25B/PTPRG/DLC1/PTPRA/HSP90B1/PPP2R5E/PTP4A2 15 GO:0006260 DNA replication 14/803 260/18722 0.227756993232237 0.465599511813341 NFIA/NFIX/NFIB/RBMS1/REV3L/NFIC/LPIN1/PURA/ATRX/FAM111A/RECQL/CCDC88A/TERF1/NUCKS1 14 GO:0051289 protein homotetramerization 4/803 57/18722 0.227850543286111 0.465599511813341 GLS/B2M/PKD2/ALDH9A1 4 GO:0051785 positive regulation of nuclear division 4/803 57/18722 0.227850543286111 0.465599511813341 PDGFRB/HOXA13/IGF2/PLCB1 4 GO:0043624 cellular protein complex disassembly 8/803 136/18722 0.229314395655132 0.468398843398808 MAP1B/PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/TAOK1/GSN 8 GO:1990748 cellular detoxification 7/803 116/18722 0.230400626085524 0.470424865545628 FBLN5/CD36/APOE/SOD3/GPX7/GPX8/GSTM3 7 GO:0071805 potassium ion transmembrane transport 12/803 219/18722 0.231927548307401 0.473348651600779 FHL1/KCNMA1/BIN1/FLNA/ATP1B1/PTEN/SLC9A9/CD63/PKD2/PRNP/ITGB1/WNK1 12 GO:0034314 Arp2/3 complex-mediated actin nucleation 3/803 39/18722 0.233539699509317 0.475859804558011 ABI2/NCKAP1/WASL 3 GO:0045923 positive regulation of fatty acid metabolic process 3/803 39/18722 0.233539699509317 0.475859804558011 IRS1/LPGAT1/TWIST1 3 GO:0046621 negative regulation of organ growth 3/803 39/18722 0.233539699509317 0.475859804558011 GJA1/PTEN/TGFBR2 3 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 3/803 39/18722 0.233539699509317 0.475859804558011 HSPA2/ATP1B1/PKD2 3 GO:0006109 regulation of carbohydrate metabolic process 10/803 178/18722 0.234822475739612 0.478082835458434 ENPP1/NNMT/IGF2/IRS1/PDK4/NUPR1/SCARB2/STAT3/PRKAA1/CLTC 10 GO:0035725 sodium ion transmembrane transport 10/803 178/18722 0.234822475739612 0.478082835458434 FXYD1/ATP1B1/SLC9A9/CAMK2D/PKD2/WNK1/TPCN1/STOM/SLC8A1/ACTN4 10 GO:0000086 G2/M transition of mitotic cell cycle 8/803 137/18722 0.235175689797543 0.478411256356812 FHL1/HSPA2/PLCB1/CDC25B/TAOK1/BACH1/ATM/USP47 8 GO:0045471 response to ethanol 8/803 137/18722 0.235175689797543 0.478411256356812 VCAM1/SPARC/CLDN1/PTEN/EIF4EBP1/EPS8/STAT3/PRKAA1 8 GO:1901987 regulation of cell cycle phase transition 20/803 390/18722 0.235956576123218 0.479804032850884 CCND2/FHL1/KANK2/ADAMTS1/HSPA2/PTEN/GPNMB/PKD1/PKD2/PLCB1/APBB2/ZFP36L2/ZFP36L1/CDC25B/KLF4/TAOK1/KMT2E/ATM/CLOCK/USP47 20 GO:0009636 response to toxic substance 14/803 262/18722 0.236126462388537 0.479953747031897 FBLN5/INMT/PDGFRB/MAP1B/CD36/APOE/CES1/SOD3/CLDN1/GPX7/NUPR1/SDC1/GPX8/GSTM3 14 GO:0006813 potassium ion transport 13/803 241/18722 0.236523380799142 0.48006018888096 FHL1/FXYD1/KCNMA1/BIN1/FLNA/ATP1B1/PTEN/SLC9A9/CD63/PKD2/PRNP/ITGB1/WNK1 13 GO:0002702 positive regulation of production of molecular mediator of immune response 7/803 117/18722 0.236789407856071 0.48006018888096 SPON2/CD36/IL1R1/HLA-A/CD81/B2M/HLA-F 7 GO:1990868 response to chemokine 6/803 97/18722 0.236994225916239 0.48006018888096 SLIT2/SLIT3/ACKR1/CMKLR1/ROBO1/WNK1 6 GO:1990869 cellular response to chemokine 6/803 97/18722 0.236994225916239 0.48006018888096 SLIT2/SLIT3/ACKR1/CMKLR1/ROBO1/WNK1 6 GO:0002931 response to ischemia 4/803 58/18722 0.237141645650583 0.48006018888096 CSF1/GJA1/EIF4EBP1/ROCK2 4 GO:0010043 response to zinc ion 4/803 58/18722 0.237141645650583 0.48006018888096 VCAM1/SLC39A13/PTEN/TSPO 4 GO:0010559 regulation of glycoprotein biosynthetic process 4/803 58/18722 0.237141645650583 0.48006018888096 SLC2A10/RAMP1/PLCB1/TMEM59 4 GO:0043525 positive regulation of neuron apoptotic process 4/803 58/18722 0.237141645650583 0.48006018888096 ITGA1/PRNP/NUPR1/FOXO3 4 GO:0043666 regulation of phosphoprotein phosphatase activity 4/803 58/18722 0.237141645650583 0.48006018888096 PDGFRB/ITGA1/ROCK2/HSP90B1 4 GO:1902808 positive regulation of cell cycle G1/S phase transition 4/803 58/18722 0.237141645650583 0.48006018888096 CCND2/ADAMTS1/PLCB1/KMT2E 4 GO:0010950 positive regulation of endopeptidase activity 10/803 179/18722 0.239975154981974 0.485599075787388 F3/UACA/ROBO1/ROCK2/EGLN3/DLC1/DAPK1/STAT3/IFI16/GSN 10 GO:0032946 positive regulation of mononuclear cell proliferation 8/803 138/18722 0.241088366241617 0.487286205955593 IGFBP2/VCAM1/CSF1/IL6ST/IGF2/HLA-A/CD81/TGFBR2 8 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 5/803 78/18722 0.242762895723651 0.487286205955593 PALM/AKAP12/LPAR1/FLNA/GNAI1 5 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 5/803 78/18722 0.242762895723651 0.487286205955593 GAS6/GPNMB/AXL/TSPO/TWIST1 5 GO:0002053 positive regulation of mesenchymal cell proliferation 2/803 22/18722 0.24295898676406 0.487286205955593 WNT2/TGFBR2 2 GO:0002320 lymphoid progenitor cell differentiation 2/803 22/18722 0.24295898676406 0.487286205955593 BMP4/SOS1 2 GO:0007398 ectoderm development 2/803 22/18722 0.24295898676406 0.487286205955593 STX2/EPB41L5 2 GO:0009190 cyclic nucleotide biosynthetic process 2/803 22/18722 0.24295898676406 0.487286205955593 GUCY1A2/ADCY3 2 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/803 22/18722 0.24295898676406 0.487286205955593 CAMK2D/SLC8A1 2 GO:0014821 phasic smooth muscle contraction 2/803 22/18722 0.24295898676406 0.487286205955593 TBX2/EDNRB 2 GO:0021854 hypothalamus development 2/803 22/18722 0.24295898676406 0.487286205955593 NRP2/NCOA1 2 GO:0032098 regulation of appetite 2/803 22/18722 0.24295898676406 0.487286205955593 SLC22A3/SPX 2 GO:0032891 negative regulation of organic acid transport 2/803 22/18722 0.24295898676406 0.487286205955593 THBS1/PLA2R1 2 GO:0034629 cellular protein-containing complex localization 2/803 22/18722 0.24295898676406 0.487286205955593 WASL/TNFAIP2 2 GO:0035357 peroxisome proliferator activated receptor signaling pathway 2/803 22/18722 0.24295898676406 0.487286205955593 TWIST1/ACTN4 2 GO:0045048 protein insertion into ER membrane 2/803 22/18722 0.24295898676406 0.487286205955593 TRAM1/TRAM2 2 GO:0045663 positive regulation of myoblast differentiation 2/803 22/18722 0.24295898676406 0.487286205955593 IGFBP3/PLCB1 2 GO:0050860 negative regulation of T cell receptor signaling pathway 2/803 22/18722 0.24295898676406 0.487286205955593 THY1/PRNP 2 GO:0052652 cyclic purine nucleotide metabolic process 2/803 22/18722 0.24295898676406 0.487286205955593 GUCY1A2/ADCY3 2 GO:0060563 neuroepithelial cell differentiation 2/803 22/18722 0.24295898676406 0.487286205955593 FAM20C/ABL1 2 GO:0099563 modification of synaptic structure 2/803 22/18722 0.24295898676406 0.487286205955593 ABL1/ITSN1 2 GO:2000114 regulation of establishment of cell polarity 2/803 22/18722 0.24295898676406 0.487286205955593 ROCK2/GSN 2 GO:2000773 negative regulation of cellular senescence 2/803 22/18722 0.24295898676406 0.487286205955593 TWIST1/ABL1 2 GO:0051101 regulation of DNA binding 7/803 118/18722 0.243235415202999 0.487644463289968 HAND2/TWIST1/RSF1/KLF4/PLAUR/SKI/IFI16 7 GO:0032642 regulation of chemokine production 6/803 98/18722 0.244114970878092 0.488425860673421 APOD/ACKR1/SNAI2/LRP1/TWIST1/KLF4 6 GO:0043473 pigmentation 6/803 98/18722 0.244114970878092 0.488425860673421 ENPP1/KITLG/SNAI2/EDNRB/ZEB2/CD63 6 GO:0061337 cardiac conduction 6/803 98/18722 0.244114970878092 0.488425860673421 GJA1/BIN1/FLNA/ATP1B1/CAMK2D/SLC8A1 6 GO:1904029 regulation of cyclin-dependent protein kinase activity 6/803 98/18722 0.244114970878092 0.488425860673421 CCND2/CAMK2N1/CCNG2/PTEN/PKD1/PKD2 6 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 6/803 98/18722 0.244114970878092 0.488425860673421 CREB3L1/SNAI2/CLU/PLAUR/HSPB1/USP47 6 GO:0009069 serine family amino acid metabolic process 3/803 40/18722 0.245095881601802 0.488573398044026 SERINC3/SERINC5/GCLM 3 GO:0031297 replication fork processing 3/803 40/18722 0.245095881601802 0.488573398044026 ATRX/FAM111A/NUCKS1 3 GO:0035329 hippo signaling 3/803 40/18722 0.245095881601802 0.488573398044026 YAP1/PJA2/AMOTL2 3 GO:0045022 early endosome to late endosome transport 3/803 40/18722 0.245095881601802 0.488573398044026 FLNA/DAB2/MSN 3 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 3/803 40/18722 0.245095881601802 0.488573398044026 THY1/PKD2/ABL1 3 GO:0055069 zinc ion homeostasis 3/803 40/18722 0.245095881601802 0.488573398044026 SLC39A13/SLC39A6/SLC39A4 3 GO:0055081 anion homeostasis 3/803 40/18722 0.245095881601802 0.488573398044026 ENPP1/CYBRD1/GLS 3 GO:1901223 negative regulation of NIK/NF-kappaB signaling 3/803 40/18722 0.245095881601802 0.488573398044026 UACA/LITAF/TSPAN6 3 GO:0007033 vacuole organization 10/803 180/18722 0.245168600462526 0.488573398044026 SRPX/SYNPO2/LAPTM4B/TMEM106B/RAB23/EXT1/NUPR1/SCARB2/RB1CC1/MBTPS1 10 GO:0071897 DNA biosynthetic process 10/803 180/18722 0.245168600462526 0.488573398044026 HGF/PDGFRB/SMOC2/GJA1/REV3L/KLF4/BMPR2/TERF1/NEK7/ATM 10 GO:0032768 regulation of monooxygenase activity 4/803 59/18722 0.246520090821641 0.490482511108021 APOE/ACVR2A/DDAH2/ZDHHC21 4 GO:0043407 negative regulation of MAP kinase activity 4/803 59/18722 0.246520090821641 0.490482511108021 BMP4/APOE/SPRY1/HIPK3 4 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4/803 59/18722 0.246520090821641 0.490482511108021 VTN/EMILIN1/AXL/HSPB1 4 GO:0071806 protein transmembrane transport 4/803 59/18722 0.246520090821641 0.490482511108021 TRAM1/SEC61A1/TRAM2/SEC62 4 GO:1905952 regulation of lipid localization 10/803 181/18722 0.250401582984953 0.498006498908246 ABCA8/CD36/THBS1/APOE/CES1/LRP1/PLTP/TSPO/PLA2R1/ABCA5 10 GO:0006446 regulation of translational initiation 5/803 79/18722 0.250850456776342 0.498302939237785 EIF4EBP1/EIF4G3/EIF4A2/EIF4EBP2/HSPB1 5 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 5/803 79/18722 0.250850456776342 0.498302939237785 PTPRD/MYADM/FLNA/MDK/ABL1 5 GO:0051279 regulation of release of sequestered calcium ion into cytosol 5/803 79/18722 0.250850456776342 0.498302939237785 THY1/CAMK2D/PKD2/ABL1/SLC8A1 5 GO:0032602 chemokine production 6/803 99/18722 0.251297441526801 0.498594923777409 APOD/ACKR1/SNAI2/LRP1/TWIST1/KLF4 6 GO:0033209 tumor necrosis factor-mediated signaling pathway 6/803 99/18722 0.251297441526801 0.498594923777409 GAS6/EXT1/TNFRSF1A/FOXO3/HIPK1/ACTN4 6 GO:0060291 long-term synaptic potentiation 6/803 99/18722 0.251297441526801 0.498594923777409 SERPINE2/APOE/PTEN/PRNP/ABL1/NPTN 6 GO:0006814 sodium ion transport 13/803 245/18722 0.254392362437333 0.504534733139437 FXYD1/SERPINE2/ATP1B1/SLC9A9/CAMK2D/PKD2/SLC5A3/SLC38A2/WNK1/TPCN1/STOM/SLC8A1/ACTN4 13 GO:0050804 modulation of chemical synaptic transmission 22/803 439/18722 0.255473184602457 0.50647685822181 CDH11/LAMA2/PTPRD/MAP1B/AKAP12/SERPINE2/APOE/CASK/PTEN/GNAI1/PRNP/PLCB1/PXK/ITGB1/PTPRA/ABL1/PREPL/MCTP2/NPTN/STAT3/CLSTN1/EIF4EBP2 22 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 4/803 60/18722 0.255977933428108 0.506671685618319 FHL1/TAOK1/ATM/USP47 4 GO:0051851 modulation by host of symbiont process 4/803 60/18722 0.255977933428108 0.506671685618319 APOE/IGF2R/STOM/NUCKS1 4 GO:0051965 positive regulation of synapse assembly 4/803 60/18722 0.255977933428108 0.506671685618319 FLRT3/PTPRD/AMIGO2/CLSTN1 4 GO:0061951 establishment of protein localization to plasma membrane 4/803 60/18722 0.255977933428108 0.506671685618319 SPTBN1/PREPL/MACF1/GOLGA4 4 GO:0032411 positive regulation of transporter activity 7/803 120/18722 0.256289162951622 0.50697130673686 HSPA2/ATP1B1/PKD2/IFNGR2/KMT2A/WNK1/ACTN4 7 GO:0010907 positive regulation of glucose metabolic process 3/803 41/18722 0.25673938016658 0.50697130673686 NNMT/IGF2/IRS1 3 GO:0031062 positive regulation of histone methylation 3/803 41/18722 0.25673938016658 0.50697130673686 KMT2A/KMT2E/RTF1 3 GO:0032735 positive regulation of interleukin-12 production 3/803 41/18722 0.25673938016658 0.50697130673686 CD36/MDK/PLCB1 3 GO:0050856 regulation of T cell receptor signaling pathway 3/803 41/18722 0.25673938016658 0.50697130673686 THY1/CD81/PRNP 3 GO:1900371 regulation of purine nucleotide biosynthetic process 3/803 41/18722 0.25673938016658 0.50697130673686 PDK4/PID1/STAT3 3 GO:0099177 regulation of trans-synaptic signaling 22/803 440/18722 0.25885710081101 0.507785999474906 CDH11/LAMA2/PTPRD/MAP1B/AKAP12/SERPINE2/APOE/CASK/PTEN/GNAI1/PRNP/PLCB1/PXK/ITGB1/PTPRA/ABL1/PREPL/MCTP2/NPTN/STAT3/CLSTN1/EIF4EBP2 22 GO:0002082 regulation of oxidative phosphorylation 2/803 23/18722 0.259086960020891 0.507785999474906 COX7A1/NUPR1 2 GO:0021884 forebrain neuron development 2/803 23/18722 0.259086960020891 0.507785999474906 NRP2/ZMIZ1 2 GO:0030539 male genitalia development 2/803 23/18722 0.259086960020891 0.507785999474906 PDGFRA/HOXA13 2 GO:0031280 negative regulation of cyclase activity 2/803 23/18722 0.259086960020891 0.507785999474906 PALM/EDNRB 2 GO:0033081 regulation of T cell differentiation in thymus 2/803 23/18722 0.259086960020891 0.507785999474906 BMP4/SOS1 2 GO:0035640 exploration behavior 2/803 23/18722 0.259086960020891 0.507785999474906 APOE/DPP4 2 GO:0035812 renal sodium excretion 2/803 23/18722 0.259086960020891 0.507785999474906 SPX/EDNRB 2 GO:0035994 response to muscle stretch 2/803 23/18722 0.259086960020891 0.507785999474906 SLC8A1/GSN 2 GO:0036119 response to platelet-derived growth factor 2/803 23/18722 0.259086960020891 0.507785999474906 PDGFRB/FER 2 GO:0042026 protein refolding 2/803 23/18722 0.259086960020891 0.507785999474906 HSPA2/B2M 2 GO:0045662 negative regulation of myoblast differentiation 2/803 23/18722 0.259086960020891 0.507785999474906 BMP4/PRICKLE1 2 GO:0050765 negative regulation of phagocytosis 2/803 23/18722 0.259086960020891 0.507785999474906 PTEN/CNN2 2 GO:0051446 positive regulation of meiotic cell cycle 2/803 23/18722 0.259086960020891 0.507785999474906 PLCB1/CDC25B 2 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 2/803 23/18722 0.259086960020891 0.507785999474906 EHD2/CAPN2 2 GO:0071305 cellular response to vitamin D 2/803 23/18722 0.259086960020891 0.507785999474906 SNAI2/KANK2 2 GO:0071514 genetic imprinting 2/803 23/18722 0.259086960020891 0.507785999474906 NDN/IGF2 2 GO:0090103 cochlea morphogenesis 2/803 23/18722 0.259086960020891 0.507785999474906 CTHRC1/PTK7 2 GO:2001169 regulation of ATP biosynthetic process 2/803 23/18722 0.259086960020891 0.507785999474906 PID1/STAT3 2 GO:0002253 activation of immune response 19/803 375/18722 0.259397633476196 0.508195127902677 C7/MFAP4/C1R/THY1/C1S/CFD/CMKLR1/C2/SERPING1/HLA-A/CD81/A2M/CLU/PRNP/CMTM3/ABL1/WNK1/IFI16/BTN3A2 19 GO:0002455 humoral immune response mediated by circulating immunoglobulin 7/803 121/18722 0.262891884936766 0.514434434181599 C7/C1R/C1S/C2/SERPING1/CD81/CLU 7 GO:0038127 ERBB signaling pathway 7/803 121/18722 0.262891884936766 0.514434434181599 ITGA1/PLAUR/ABL1/RTN4/FER/CCDC88A/SOS1 7 GO:0042177 negative regulation of protein catabolic process 7/803 121/18722 0.262891884936766 0.514434434181599 SERPINE2/TIMP1/FLNA/LAPTM4B/TIMP3/TIMP2/CTSA 7 GO:0046467 membrane lipid biosynthetic process 8/803 142/18722 0.265214799126009 0.517926240080317 ELOVL2/ABCA8/PLPP1/PLPP3/SGMS1/PRKAA1/CERS2/CERS6 8 GO:0050729 positive regulation of inflammatory response 8/803 142/18722 0.265214799126009 0.517926240080317 PLA2G2A/OSMR/IL6ST/CD81/MDK/NUPR1/TNFRSF1A/CLOCK 8 GO:0040014 regulation of multicellular organism growth 4/803 61/18722 0.265507314409404 0.517926240080317 CSF1/IGF2/SOCS2/STAT3 4 GO:0043030 regulation of macrophage activation 4/803 61/18722 0.265507314409404 0.517926240080317 THBS1/MFHAS1/GPR137B/PJA2 4 GO:0043954 cellular component maintenance 4/803 61/18722 0.265507314409404 0.517926240080317 APOE/CLDN1/PRNP/TJP1 4 GO:0060997 dendritic spine morphogenesis 4/803 61/18722 0.265507314409404 0.517926240080317 PTEN/PDLIM5/ABI2/WASL 4 GO:0060998 regulation of dendritic spine development 4/803 61/18722 0.265507314409404 0.517926240080317 APOE/PTEN/ASAP1/ITSN1 4 GO:0090342 regulation of cell aging 4/803 61/18722 0.265507314409404 0.517926240080317 PTEN/B2M/TWIST1/ABL1 4 GO:0051963 regulation of synapse assembly 6/803 101/18722 0.265833891457082 0.518157850979285 FLRT3/PTPRD/AMIGO2/PDLIM5/CLSTN1/FARP1 6 GO:0098869 cellular oxidant detoxification 6/803 101/18722 0.265833891457082 0.518157850979285 FBLN5/CD36/APOE/SOD3/GPX7/GPX8 6 GO:0001523 retinoid metabolic process 5/803 81/18722 0.267220705969188 0.519208902905534 RARRES2/RBP1/CRABP1/RDH10/LRP1 5 GO:0001960 negative regulation of cytokine-mediated signaling pathway 5/803 81/18722 0.267220705969188 0.519208902905534 SLIT2/ECM1/SLIT3/GAS6/ROBO1 5 GO:0051149 positive regulation of muscle cell differentiation 5/803 81/18722 0.267220705969188 0.519208902905534 EFEMP2/BMP4/EFNB2/PIEZO1/ENG 5 GO:0051817 modulation of process of other organism involved in symbiotic interaction 5/803 81/18722 0.267220705969188 0.519208902905534 APOE/IGF2R/STOM/SERPINB9/NUCKS1 5 GO:2000106 regulation of leukocyte apoptotic process 5/803 81/18722 0.267220705969188 0.519208902905534 KITLG/GAS6/BMP4/PTEN/AXL 5 GO:2001021 negative regulation of response to DNA damage stimulus 5/803 81/18722 0.267220705969188 0.519208902905534 SNAI2/CLU/TWIST1/RNF169/USP47 5 GO:0006040 amino sugar metabolic process 3/803 42/18722 0.268455786540407 0.519208902905534 CSGALNACT1/PGM3/UAP1 3 GO:0010677 negative regulation of cellular carbohydrate metabolic process 3/803 42/18722 0.268455786540407 0.519208902905534 ENPP1/NUPR1/STAT3 3 GO:0014003 oligodendrocyte development 3/803 42/18722 0.268455786540407 0.519208902905534 CD9/PTEN/CLU 3 GO:0016601 Rac protein signal transduction 3/803 42/18722 0.268455786540407 0.519208902905534 ABI2/EPS8/NCKAP1 3 GO:0021575 hindbrain morphogenesis 3/803 42/18722 0.268455786540407 0.519208902905534 SERPINE2/DLC1/ABL1 3 GO:0021879 forebrain neuron differentiation 3/803 42/18722 0.268455786540407 0.519208902905534 NRP2/B2M/ZMIZ1 3 GO:0030808 regulation of nucleotide biosynthetic process 3/803 42/18722 0.268455786540407 0.519208902905534 PDK4/PID1/STAT3 3 GO:0032689 negative regulation of interferon-gamma production 3/803 42/18722 0.268455786540407 0.519208902905534 GAS6/AXL/PRNP 3 GO:0042168 heme metabolic process 3/803 42/18722 0.268455786540407 0.519208902905534 BDH2/TSPO/PGRMC1 3 GO:0051602 response to electrical stimulus 3/803 42/18722 0.268455786540407 0.519208902905534 PALM/AKAP12/PTEN 3 GO:0072595 maintenance of protein localization in organelle 3/803 42/18722 0.268455786540407 0.519208902905534 GJA1/TSPO/SYNE1 3 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 3/803 42/18722 0.268455786540407 0.519208902905534 THBS1/SPRED1/KLF4 3 GO:1903432 regulation of TORC1 signaling 3/803 42/18722 0.268455786540407 0.519208902905534 SESN3/GPR137B/ATM 3 GO:2000404 regulation of T cell migration 3/803 42/18722 0.268455786540407 0.519208902905534 APOD/ECM1/WNK1 3 GO:0051208 sequestering of calcium ion 7/803 122/18722 0.269541801962453 0.521107182855676 THY1/CAMK2D/PKD2/ABL1/HSP90B1/TPCN1/SLC8A1 7 GO:1901988 negative regulation of cell cycle phase transition 13/803 249/18722 0.272733747651878 0.526287619490506 FHL1/KANK2/PTEN/GPNMB/PKD2/APBB2/ZFP36L2/ZFP36L1/KLF4/TAOK1/ATM/CLOCK/USP47 13 GO:0006672 ceramide metabolic process 6/803 102/18722 0.273181015714918 0.526287619490506 PLPP1/PLPP3/SGMS1/PRKAA1/CERS2/CERS6 6 GO:0010522 regulation of calcium ion transport into cytosol 6/803 102/18722 0.273181015714918 0.526287619490506 THY1/CAMK2D/PKD2/PRNP/ABL1/SLC8A1 6 GO:1902749 regulation of cell cycle G2/M phase transition 6/803 102/18722 0.273181015714918 0.526287619490506 FHL1/HSPA2/CDC25B/TAOK1/ATM/USP47 6 GO:1904063 negative regulation of cation transmembrane transport 6/803 102/18722 0.273181015714918 0.526287619490506 BIN1/PTEN/CAMK2D/PKD2/TWIST1/SESTD1 6 GO:0046394 carboxylic acid biosynthetic process 16/803 314/18722 0.274667297582281 0.526287619490506 PTGDS/RBP1/ELOVL2/CES1/PLOD2/RDH10/PDK4/GLS/UGDH/LPGAT1/SERINC3/OSBPL1A/PRKAA1/SERINC5/OAT/FADS3 16 GO:0019933 cAMP-mediated signaling 4/803 62/18722 0.275100474760758 0.526287619490506 PDE3A/PDE3B/GNAI1/EIF4EBP2 4 GO:0032731 positive regulation of interleukin-1 beta production 4/803 62/18722 0.275100474760758 0.526287619490506 CD36/STAT3/IFI16/HSPB1 4 GO:0060135 maternal process involved in female pregnancy 4/803 62/18722 0.275100474760758 0.526287619490506 STC1/GJA1/BMPR2/ASH1L 4 GO:0060675 ureteric bud morphogenesis 4/803 62/18722 0.275100474760758 0.526287619490506 TCF21/BMP4/GPC3/PKD2 4 GO:0070265 necrotic cell death 4/803 62/18722 0.275100474760758 0.526287619490506 TSPO/NUPR1/IPMK/TMEM123 4 GO:1902750 negative regulation of cell cycle G2/M phase transition 4/803 62/18722 0.275100474760758 0.526287619490506 FHL1/TAOK1/ATM/USP47 4 GO:0010155 regulation of proton transport 2/803 24/18722 0.275225753789802 0.526287619490506 TWIST1/ACTN4 2 GO:0010288 response to lead ion 2/803 24/18722 0.275225753789802 0.526287619490506 SPARC/CLDN1 2 GO:0016486 peptide hormone processing 2/803 24/18722 0.275225753789802 0.526287619490506 ECE1/PCSK6 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/803 24/18722 0.275225753789802 0.526287619490506 PID1/STAT3 2 GO:0030859 polarized epithelial cell differentiation 2/803 24/18722 0.275225753789802 0.526287619490506 PTK7/MSN 2 GO:0032528 microvillus organization 2/803 24/18722 0.275225753789802 0.526287619490506 FSCN1/RAP2A 2 GO:0036010 protein localization to endosome 2/803 24/18722 0.275225753789802 0.526287619490506 ROCK2/MSN 2 GO:0038095 Fc-epsilon receptor signaling pathway 2/803 24/18722 0.275225753789802 0.526287619490506 FER/SOS1 2 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 2/803 24/18722 0.275225753789802 0.526287619490506 PUM2/TSPAN6 2 GO:0045649 regulation of macrophage differentiation 2/803 24/18722 0.275225753789802 0.526287619490506 CSF1/PRKCA 2 GO:0050687 negative regulation of defense response to virus 2/803 24/18722 0.275225753789802 0.526287619490506 HTRA1/TSPAN6 2 GO:0050855 regulation of B cell receptor signaling pathway 2/803 24/18722 0.275225753789802 0.526287619490506 CD81/CMTM3 2 GO:0051923 sulfation 2/803 24/18722 0.275225753789802 0.526287619490506 TPST1/EXT1 2 GO:0070841 inclusion body assembly 2/803 24/18722 0.275225753789802 0.526287619490506 HSPA2/CLU 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/803 24/18722 0.275225753789802 0.526287619490506 PID1/STAT3 2 GO:2000310 regulation of NMDA receptor activity 2/803 24/18722 0.275225753789802 0.526287619490506 IFNGR2/DAPK1 2 GO:0001910 regulation of leukocyte mediated cytotoxicity 5/803 82/18722 0.275493519227882 0.526287619490506 HLA-B/HLA-A/B2M/HLA-F/SERPINB9 5 GO:0046889 positive regulation of lipid biosynthetic process 5/803 82/18722 0.275493519227882 0.526287619490506 APOE/RDH10/LPGAT1/CAPN2/PRKAA1 5 GO:1905897 regulation of response to endoplasmic reticulum stress 5/803 82/18722 0.275493519227882 0.526287619490506 CREB3L1/CLU/PIK3R1/NUPR1/SERINC3 5 GO:0050852 T cell receptor signaling pathway 7/803 123/18722 0.276236372305654 0.527504615977018 THY1/HLA-A/CD81/PRNP/ABL1/WNK1/BTN3A2 7 GO:1902115 regulation of organelle assembly 10/803 186/18722 0.277115517647037 0.528980846473248 PTPRD/FSCN1/YAP1/NUPR1/SDC1/ASAP1/PRKAA1/MSN/CCDC88A/GSN 10 GO:0021983 pituitary gland development 3/803 43/18722 0.280231151276072 0.532481905587841 PITX2/PITX1/BMP4 3 GO:0030517 negative regulation of axon extension 3/803 43/18722 0.280231151276072 0.532481905587841 SEMA3B/SEMA6D/RTN4 3 GO:0032365 intracellular lipid transport 3/803 43/18722 0.280231151276072 0.532481905587841 CES1/LRP6/NPC2 3 GO:0033173 calcineurin-NFAT signaling cascade 3/803 43/18722 0.280231151276072 0.532481905587841 LMCD1/NFAT5/PRNP 3 GO:0042181 ketone biosynthetic process 3/803 43/18722 0.280231151276072 0.532481905587841 BMP5/DKK3/H6PD 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/803 43/18722 0.280231151276072 0.532481905587841 NUPR1/HIPK1/IFI16 3 GO:0045840 positive regulation of mitotic nuclear division 3/803 43/18722 0.280231151276072 0.532481905587841 PDGFRB/HOXA13/IGF2 3 GO:0045981 positive regulation of nucleotide metabolic process 3/803 43/18722 0.280231151276072 0.532481905587841 PID1/STAT3/PRKAA1 3 GO:0098927 vesicle-mediated transport between endosomal compartments 3/803 43/18722 0.280231151276072 0.532481905587841 FLNA/DAB2/MSN 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/803 43/18722 0.280231151276072 0.532481905587841 PID1/STAT3/PRKAA1 3 GO:1901381 positive regulation of potassium ion transmembrane transport 3/803 43/18722 0.280231151276072 0.532481905587841 FLNA/ATP1B1/WNK1 3 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 3/803 43/18722 0.280231151276072 0.532481905587841 SRPX/SNAI2/FGFR1 3 GO:0002027 regulation of heart rate 6/803 103/18722 0.280576165125283 0.532528648387765 SPX/BIN1/CAMK2D/EPAS1/TPM1/SLC8A1 6 GO:0030004 cellular monovalent inorganic cation homeostasis 6/803 103/18722 0.280576165125283 0.532528648387765 C7/KCNMA1/ATP1B1/SLC9A9/TMEM106B/SLC8A1 6 GO:0050773 regulation of dendrite development 6/803 103/18722 0.280576165125283 0.532528648387765 BMP5/PTPRD/SDC2/TMEM106B/RAP2A/VLDLR 6 GO:0097237 cellular response to toxic substance 7/803 124/18722 0.282973046690713 0.536689469004845 FBLN5/CD36/APOE/SOD3/GPX7/GPX8/GSTM3 7 GO:0016053 organic acid biosynthetic process 16/803 316/18722 0.282983677098624 0.536689469004845 PTGDS/RBP1/ELOVL2/CES1/PLOD2/RDH10/PDK4/GLS/UGDH/LPGAT1/SERINC3/OSBPL1A/PRKAA1/SERINC5/OAT/FADS3 16 GO:0031343 positive regulation of cell killing 4/803 63/18722 0.284749768179293 0.539423383032658 HLA-B/HLA-A/B2M/HLA-F 4 GO:0050854 regulation of antigen receptor-mediated signaling pathway 4/803 63/18722 0.284749768179293 0.539423383032658 THY1/CD81/PRNP/CMTM3 4 GO:0072171 mesonephric tubule morphogenesis 4/803 63/18722 0.284749768179293 0.539423383032658 TCF21/BMP4/GPC3/PKD2 4 GO:0006959 humoral immune response 16/803 317/18722 0.287173073122222 0.543807422175237 CXCL14/C7/RARRES2/MFAP4/C1R/SPON2/C1S/GATA6/CFD/C2/SERPING1/HLA-A/CD81/A2M/CLU/NOTCH2 16 GO:0006575 cellular modified amino acid metabolic process 10/803 188/18722 0.288033300141546 0.545229322135819 SLC16A10/CTSK/PLOD2/SERINC1/SERINC3/ALDH9A1/GLO1/SERINC5/GSTM3/GCLM 10 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 8/803 146/18722 0.290008997012926 0.54610722312302 PTGFR/ADCY3/LPAR1/PRKCA/PTGER2/ADGRD1/RAMP1/AKAP13 8 GO:0010675 regulation of cellular carbohydrate metabolic process 8/803 146/18722 0.290008997012926 0.54610722312302 ENPP1/NNMT/IGF2/IRS1/PDK4/NUPR1/SCARB2/STAT3 8 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 2/803 25/18722 0.291344808164306 0.54610722312302 GAS6/GJA1 2 GO:0010842 retina layer formation 2/803 25/18722 0.291344808164306 0.54610722312302 PROM1/HIPK1 2 GO:0010954 positive regulation of protein processing 2/803 25/18722 0.291344808164306 0.54610722312302 SPON1/GSN 2 GO:0016540 protein autoprocessing 2/803 25/18722 0.291344808164306 0.54610722312302 CAPN2/FAM111A 2 GO:0031579 membrane raft organization 2/803 25/18722 0.291344808164306 0.54610722312302 MYADM/GSN 2 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 2/803 25/18722 0.291344808164306 0.54610722312302 CD36/PRKCA 2 GO:0032878 regulation of establishment or maintenance of cell polarity 2/803 25/18722 0.291344808164306 0.54610722312302 ROCK2/GSN 2 GO:0035902 response to immobilization stress 2/803 25/18722 0.291344808164306 0.54610722312302 FOXO3/SLC8A1 2 GO:0036315 cellular response to sterol 2/803 25/18722 0.291344808164306 0.54610722312302 CES1/LRP6 2 GO:0044550 secondary metabolite biosynthetic process 2/803 25/18722 0.291344808164306 0.54610722312302 ZEB2/BDH2 2 GO:0045822 negative regulation of heart contraction 2/803 25/18722 0.291344808164306 0.54610722312302 SPX/BIN1 2 GO:0046039 GTP metabolic process 2/803 25/18722 0.291344808164306 0.54610722312302 RAB23/RHOQ 2 GO:0050995 negative regulation of lipid catabolic process 2/803 25/18722 0.291344808164306 0.54610722312302 PDE3B/PRKAA1 2 GO:0060706 cell differentiation involved in embryonic placenta development 2/803 25/18722 0.291344808164306 0.54610722312302 SOCS3/HECTD1 2 GO:0061436 establishment of skin barrier 2/803 25/18722 0.291344808164306 0.54610722312302 CLDN1/PLEC 2 GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/803 25/18722 0.291344808164306 0.54610722312302 FLNA/ATP1B1 2 GO:0090312 positive regulation of protein deacetylation 2/803 25/18722 0.291344808164306 0.54610722312302 NDN/NNMT 2 GO:0098581 detection of external biotic stimulus 2/803 25/18722 0.291344808164306 0.54610722312302 HLA-B/HLA-A 2 GO:0098703 calcium ion import across plasma membrane 2/803 25/18722 0.291344808164306 0.54610722312302 PRNP/SLC8A1 2 GO:0099560 synaptic membrane adhesion 2/803 25/18722 0.291344808164306 0.54610722312302 FLRT3/PTPRD 2 GO:0140448 signaling receptor ligand precursor processing 2/803 25/18722 0.291344808164306 0.54610722312302 ECE1/PCSK6 2 GO:1903959 regulation of anion transmembrane transport 2/803 25/18722 0.291344808164306 0.54610722312302 PRNP/ITGB1 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/803 25/18722 0.291344808164306 0.54610722312302 PRKG1/TPM1 2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 2/803 25/18722 0.291344808164306 0.54610722312302 MDK/NFAT5 2 GO:0005978 glycogen biosynthetic process 3/803 44/18722 0.292051997540998 0.546254018844386 ENPP1/IGF2/IRS1 3 GO:0008542 visual learning 3/803 44/18722 0.292051997540998 0.546254018844386 MEIS2/ITGB1/NPTN 3 GO:0009250 glucan biosynthetic process 3/803 44/18722 0.292051997540998 0.546254018844386 ENPP1/IGF2/IRS1 3 GO:0032007 negative regulation of TOR signaling 3/803 44/18722 0.292051997540998 0.546254018844386 SESN3/PRKAA1/ATM 3 GO:1903214 regulation of protein targeting to mitochondrion 3/803 44/18722 0.292051997540998 0.546254018844386 NPEPPS/PRKAA1/BNIP3L 3 GO:0010921 regulation of phosphatase activity 5/803 84/18722 0.292190025723622 0.546254018844386 PDGFRB/ITGA1/ROCK2/LPIN1/HSP90B1 5 GO:1900542 regulation of purine nucleotide metabolic process 5/803 84/18722 0.292190025723622 0.546254018844386 PDK4/NUPR1/PID1/STAT3/PRKAA1 5 GO:0006940 regulation of smooth muscle contraction 4/803 64/18722 0.294447672647797 0.549650354107792 SPX/PRKG1/KCNMA1/ZDHHC21 4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 4/803 64/18722 0.294447672647797 0.549650354107792 CAMK2N1/LRP1/SIDT2/MAP4K4 4 GO:1903018 regulation of glycoprotein metabolic process 4/803 64/18722 0.294447672647797 0.549650354107792 SLC2A10/RAMP1/PLCB1/TMEM59 4 GO:1903409 reactive oxygen species biosynthetic process 4/803 64/18722 0.294447672647797 0.549650354107792 CD36/SLC5A3/FOXO3/STAT3 4 GO:0062207 regulation of pattern recognition receptor signaling pathway 6/803 105/18722 0.295496838841103 0.551402409603944 CD36/MFHAS1/RTN4/PUM2/PJA2/TSPAN6 6 GO:0042180 cellular ketone metabolic process 11/803 211/18722 0.296734804845467 0.553298330949701 BMP5/DKK3/CES1/RDH10/IRS1/PDK4/NCOR2/LPGAT1/TWIST1/H6PD/GLO1 11 GO:0046474 glycerophospholipid biosynthetic process 11/803 211/18722 0.296734804845467 0.553298330949701 PTEN/PIK3R1/SOCS2/CISH/AGPAT2/LPCAT2/SOCS3/LPIN1/CAPN2/ATM/IPMK 11 GO:0031647 regulation of protein stability 15/803 298/18722 0.298999079696886 0.557311929483616 CRYAB/PLPP3/FLNA/ATP1B1/CD81/PTEN/CLU/PIK3R1/CRTAP/PRNP/RTN4/GSN/CTSA/USP47/USP9X 15 GO:0009152 purine ribonucleotide biosynthetic process 9/803 169/18722 0.301082643705714 0.560985822689345 GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/PID1/STAT3/PANK3/PAPSS1 9 GO:0006457 protein folding 11/803 212/18722 0.301985440325583 0.56224772422082 LTBP4/CRYAB/HSPA2/PPIC/B2M/CLU/CRTAP/HSP90B1/FKBP9/CANX/HSPB1 11 GO:0043523 regulation of neuron apoptotic process 11/803 212/18722 0.301985440325583 0.56224772422082 ITGA1/APOE/ANGPT1/MDK/LRP1/AXL/EGLN3/PRNP/NUPR1/FOXO3/GCLM 11 GO:0043484 regulation of RNA splicing 8/803 148/18722 0.302616962605864 0.562793053171518 SON/PIK3R1/CELF2/AHNAK/DDX17/SLC38A2/MBNL2/SETX 8 GO:0044839 cell cycle G2/M phase transition 8/803 148/18722 0.302616962605864 0.562793053171518 FHL1/HSPA2/PLCB1/CDC25B/TAOK1/BACH1/ATM/USP47 8 GO:2001056 positive regulation of cysteine-type endopeptidase activity 8/803 148/18722 0.302616962605864 0.562793053171518 F3/UACA/ROBO1/EGLN3/DLC1/DAPK1/IFI16/GSN 8 GO:0042116 macrophage activation 6/803 106/18722 0.303015537483859 0.563324187134423 THBS1/MFHAS1/CLU/IFNGR2/GPR137B/PJA2 6 GO:0002920 regulation of humoral immune response 3/803 45/18722 0.303905331408537 0.564137000150024 GATA6/SERPING1/A2M 3 GO:0006110 regulation of glycolytic process 3/803 45/18722 0.303905331408537 0.564137000150024 NUPR1/STAT3/PRKAA1 3 GO:0035307 positive regulation of protein dephosphorylation 3/803 45/18722 0.303905331408537 0.564137000150024 PDGFRB/ITGA1/DLC1 3 GO:0048599 oocyte development 3/803 45/18722 0.303905331408537 0.564137000150024 PDE3A/CDC25B/FOXO3 3 GO:0046513 ceramide biosynthetic process 4/803 65/18722 0.304186800994088 0.564239356308231 SGMS1/PRKAA1/CERS2/CERS6 4 GO:0048524 positive regulation of viral process 4/803 65/18722 0.304186800994088 0.564239356308231 LGALS1/AXL/RSF1/STOM 4 GO:0050821 protein stabilization 10/803 191/18722 0.304625952260639 0.56484380735275 CRYAB/PLPP3/FLNA/ATP1B1/PTEN/CLU/PIK3R1/CRTAP/RTN4/USP9X 10 GO:0002026 regulation of the force of heart contraction 2/803 26/18722 0.307416158575141 0.565183247291907 CAMK2D/SLC8A1 2 GO:0002092 positive regulation of receptor internalization 2/803 26/18722 0.307416158575141 0.565183247291907 ANGPT1/CD63 2 GO:0006517 protein deglycosylation 2/803 26/18722 0.307416158575141 0.565183247291907 MAN1A1/AMFR 2 GO:0018027 peptidyl-lysine dimethylation 2/803 26/18722 0.307416158575141 0.565183247291907 KMT2A/ASH1L 2 GO:0032682 negative regulation of chemokine production 2/803 26/18722 0.307416158575141 0.565183247291907 APOD/KLF4 2 GO:0033598 mammary gland epithelial cell proliferation 2/803 26/18722 0.307416158575141 0.565183247291907 ROBO1/RTN4 2 GO:0034063 stress granule assembly 2/803 26/18722 0.307416158575141 0.565183247291907 PRKAA1/PUM2 2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/803 26/18722 0.307416158575141 0.565183247291907 MAP1B/ARMCX3 2 GO:0042634 regulation of hair cycle 2/803 26/18722 0.307416158575141 0.565183247291907 FST/CLOCK 2 GO:0045672 positive regulation of osteoclast differentiation 2/803 26/18722 0.307416158575141 0.565183247291907 CSF1/NOTCH2 2 GO:0047497 mitochondrion transport along microtubule 2/803 26/18722 0.307416158575141 0.565183247291907 MAP1B/ARMCX3 2 GO:0048843 negative regulation of axon extension involved in axon guidance 2/803 26/18722 0.307416158575141 0.565183247291907 SEMA3B/SEMA6D 2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 2/803 26/18722 0.307416158575141 0.565183247291907 CD81/CMTM3 2 GO:0051016 barbed-end actin filament capping 2/803 26/18722 0.307416158575141 0.565183247291907 EPS8/GSN 2 GO:0051350 negative regulation of lyase activity 2/803 26/18722 0.307416158575141 0.565183247291907 PALM/EDNRB 2 GO:0060219 camera-type eye photoreceptor cell differentiation 2/803 26/18722 0.307416158575141 0.565183247291907 THY1/PROM1 2 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/803 26/18722 0.307416158575141 0.565183247291907 CAMK2D/PKD2 2 GO:0070193 synaptonemal complex organization 2/803 26/18722 0.307416158575141 0.565183247291907 HSPA2/P3H4 2 GO:0071425 hematopoietic stem cell proliferation 2/803 26/18722 0.307416158575141 0.565183247291907 KITLG/N4BP2L2 2 GO:1902656 calcium ion import into cytosol 2/803 26/18722 0.307416158575141 0.565183247291907 PRNP/SLC8A1 2 GO:1903523 negative regulation of blood circulation 2/803 26/18722 0.307416158575141 0.565183247291907 SPX/BIN1 2 GO:1904353 regulation of telomere capping 2/803 26/18722 0.307416158575141 0.565183247291907 NEK7/ATM 2 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 2/803 26/18722 0.307416158575141 0.565183247291907 EFEMP2/ENG 2 GO:0006140 regulation of nucleotide metabolic process 5/803 86/18722 0.309055470352558 0.567987679755936 PDK4/NUPR1/PID1/STAT3/PRKAA1 5 GO:0033865 nucleoside bisphosphate metabolic process 7/803 128/18722 0.310289696652615 0.569416425288899 ENPP1/ELOVL2/TPST1/PAPSS2/PDK4/PANK3/PAPSS1 7 GO:0033875 ribonucleoside bisphosphate metabolic process 7/803 128/18722 0.310289696652615 0.569416425288899 ENPP1/ELOVL2/TPST1/PAPSS2/PDK4/PANK3/PAPSS1 7 GO:0034032 purine nucleoside bisphosphate metabolic process 7/803 128/18722 0.310289696652615 0.569416425288899 ENPP1/ELOVL2/TPST1/PAPSS2/PDK4/PANK3/PAPSS1 7 GO:0035303 regulation of dephosphorylation 7/803 128/18722 0.310289696652615 0.569416425288899 PDGFRB/ITGA1/MFHAS1/ROCK2/DLC1/LPIN1/HSP90B1 7 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/803 107/18722 0.3105686182247 0.569718591047959 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F 6 GO:0006913 nucleocytoplasmic transport 15/803 301/18722 0.312307347113605 0.572486923789866 APOD/GAS6/CD36/BMP4/ANGPT1/PRICKLE1/FLNA/RAB23/PKD1/PIK3R1/TXNIP/PKIG/STAT3/ATXN1/AKAP13 15 GO:0051169 nuclear transport 15/803 301/18722 0.312307347113605 0.572486923789866 APOD/GAS6/CD36/BMP4/ANGPT1/PRICKLE1/FLNA/RAB23/PKD1/PIK3R1/TXNIP/PKIG/STAT3/ATXN1/AKAP13 15 GO:0019229 regulation of vasoconstriction 4/803 66/18722 0.313959910464826 0.575304709142824 GJA1/ECE1/BMPR2/ZDHHC21 4 GO:0042398 cellular modified amino acid biosynthetic process 3/803 46/18722 0.315778649330655 0.578212392788338 PLOD2/ALDH9A1/GCLM 3 GO:0046839 phospholipid dephosphorylation 3/803 46/18722 0.315778649330655 0.578212392788338 PLPP1/PLPP3/PTEN 3 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7/803 129/18722 0.317198588558998 0.580371191531061 F3/UACA/ROBO1/EGLN3/DLC1/DAPK1/GSN 7 GO:0001776 leukocyte homeostasis 5/803 87/18722 0.317539633071948 0.580371191531061 KITLG/AXL/ABL1/SKIL/SOS1 5 GO:0016101 diterpenoid metabolic process 5/803 87/18722 0.317539633071948 0.580371191531061 RARRES2/RBP1/CRABP1/RDH10/LRP1 5 GO:0019915 lipid storage 5/803 87/18722 0.317539633071948 0.580371191531061 ENPP1/CD36/APOE/CES1/MEST 5 GO:0051262 protein tetramerization 5/803 87/18722 0.317539633071948 0.580371191531061 PKD1/GLS/B2M/PKD2/ALDH9A1 5 GO:0006958 complement activation, classical pathway 6/803 108/18722 0.318152711177626 0.580852954204191 C7/C1R/C1S/C2/SERPING1/CLU 6 GO:0007173 epidermal growth factor receptor signaling pathway 6/803 108/18722 0.318152711177626 0.580852954204191 ITGA1/PLAUR/ABL1/FER/CCDC88A/SOS1 6 GO:0034440 lipid oxidation 6/803 108/18722 0.318152711177626 0.580852954204191 APOD/BDH2/IRS1/PDK4/TWIST1/PRKAA1 6 GO:0006783 heme biosynthetic process 2/803 27/18722 0.323414269840972 0.58637947251894 TSPO/PGRMC1 2 GO:0007026 negative regulation of microtubule depolymerization 2/803 27/18722 0.323414269840972 0.58637947251894 MAP1B/TAOK1 2 GO:0009651 response to salt stress 2/803 27/18722 0.323414269840972 0.58637947251894 CLDN1/ZFP36L1 2 GO:0010561 negative regulation of glycoprotein biosynthetic process 2/803 27/18722 0.323414269840972 0.58637947251894 SLC2A10/TMEM59 2 GO:0010586 miRNA metabolic process 2/803 27/18722 0.323414269840972 0.58637947251894 KCNQ1OT1/DDX17 2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 2/803 27/18722 0.323414269840972 0.58637947251894 HSPA2/CDC25B 2 GO:0032781 positive regulation of ATPase activity 2/803 27/18722 0.323414269840972 0.58637947251894 ATP1B1/TPM1 2 GO:0033561 regulation of water loss via skin 2/803 27/18722 0.323414269840972 0.58637947251894 CLDN1/PLEC 2 GO:0033688 regulation of osteoblast proliferation 2/803 27/18722 0.323414269840972 0.58637947251894 CTHRC1/ABL1 2 GO:0034505 tooth mineralization 2/803 27/18722 0.323414269840972 0.58637947251894 COL1A1/FAM20C 2 GO:0035459 vesicle cargo loading 2/803 27/18722 0.323414269840972 0.58637947251894 SEC31A/SAR1A 2 GO:0042104 positive regulation of activated T cell proliferation 2/803 27/18722 0.323414269840972 0.58637947251894 IGFBP2/IGF2 2 GO:0042403 thyroid hormone metabolic process 2/803 27/18722 0.323414269840972 0.58637947251894 SLC16A10/CTSK 2 GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/803 27/18722 0.323414269840972 0.58637947251894 EHD2/CAPN2 2 GO:0060333 interferon-gamma-mediated signaling pathway 2/803 27/18722 0.323414269840972 0.58637947251894 IFNGR2/JAK1 2 GO:0070861 regulation of protein exit from endoplasmic reticulum 2/803 27/18722 0.323414269840972 0.58637947251894 CD81/SAR1A 2 GO:0098901 regulation of cardiac muscle cell action potential 2/803 27/18722 0.323414269840972 0.58637947251894 BIN1/CAMK2D 2 GO:1903205 regulation of hydrogen peroxide-induced cell death 2/803 27/18722 0.323414269840972 0.58637947251894 HGF/FOXO3 2 GO:1903319 positive regulation of protein maturation 2/803 27/18722 0.323414269840972 0.58637947251894 SPON1/GSN 2 GO:0061077 chaperone-mediated protein folding 4/803 67/18722 0.323759911353133 0.586579548694303 HSPA2/CLU/CRTAP/HSPB1 4 GO:0061180 mammary gland epithelium development 4/803 67/18722 0.323759911353133 0.586579548694303 WNT2/CSF1/ROBO1/RTN4 4 GO:0051091 positive regulation of DNA-binding transcription factor activity 13/803 260/18722 0.325190186513819 0.588956872487432 WNT2/CYTL1/DDR2/CD36/PLPP3/PTEN/MTDH/CLU/LRP6/ARID5B/STAT3/FER/CLOCK 13 GO:0006821 chloride transport 6/803 109/18722 0.325764470510756 0.589354735111259 FXYD1/CLCN5/APOL1/TSPO/PRNP/ANO10 6 GO:0032414 positive regulation of ion transmembrane transporter activity 6/803 109/18722 0.325764470510756 0.589354735111259 HSPA2/ATP1B1/PKD2/IFNGR2/WNK1/ACTN4 6 GO:0034766 negative regulation of ion transmembrane transport 6/803 109/18722 0.325764470510756 0.589354735111259 BIN1/PTEN/CAMK2D/PKD2/TWIST1/SESTD1 6 GO:0030101 natural killer cell activation 5/803 88/18722 0.32605184768756 0.589660686459984 GAS6/AXL/HLA-F/SP3/HECTD1 5 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 3/803 47/18722 0.327659943059707 0.591282112231523 CREB3L1/EPAS1/BACH1 3 GO:0048512 circadian behavior 3/803 47/18722 0.327659943059707 0.591282112231523 PTGDS/PTEN/ZFHX3 3 GO:0051972 regulation of telomerase activity 3/803 47/18722 0.327659943059707 0.591282112231523 KLF4/TERF1/NEK7 3 GO:0061001 regulation of dendritic spine morphogenesis 3/803 47/18722 0.327659943059707 0.591282112231523 PTEN/PDLIM5/ABI2 3 GO:0120163 negative regulation of cold-induced thermogenesis 3/803 47/18722 0.327659943059707 0.591282112231523 ADAMTS5/LAMA4/LNPEP 3 GO:1903170 negative regulation of calcium ion transmembrane transport 3/803 47/18722 0.327659943059707 0.591282112231523 BIN1/PKD2/SESTD1 3 GO:0006661 phosphatidylinositol biosynthetic process 7/803 131/18722 0.331094273655019 0.597263403923273 PTEN/PIK3R1/SOCS2/CISH/SOCS3/ATM/IPMK 7 GO:0007088 regulation of mitotic nuclear division 6/803 110/18722 0.333400578011312 0.600443774495636 PDGFRB/HOXA13/BMP4/IGF2/CCDC8/ATM 6 GO:0007585 respiratory gaseous exchange by respiratory system 4/803 68/18722 0.333579874719798 0.600443774495636 NDN/ELN/GLS/SLC5A3 4 GO:0042267 natural killer cell mediated cytotoxicity 4/803 68/18722 0.333579874719798 0.600443774495636 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0051148 negative regulation of muscle cell differentiation 4/803 68/18722 0.333579874719798 0.600443774495636 PRDM6/IGF2/BMPR2/FRS2 4 GO:0051926 negative regulation of calcium ion transport 4/803 68/18722 0.333579874719798 0.600443774495636 STC1/BIN1/PKD2/SESTD1 4 GO:1901016 regulation of potassium ion transmembrane transporter activity 4/803 68/18722 0.333579874719798 0.600443774495636 FHL1/ATP1B1/PTEN/ITGB1 4 GO:0002443 leukocyte mediated immunity 21/803 440/18722 0.338384057970585 0.606345156506934 PTGDS/C7/C1R/SPON2/C1S/IL1R1/C2/HLA-B/SERPING1/HLA-A/CD81/B2M/CLU/BST2/HLA-F/JAG1/FER/KMT2E/SERPINB9/NDFIP1/BTN3A2 21 GO:0042594 response to starvation 10/803 197/18722 0.338456352217077 0.606345156506934 GAS6/PDK4/EIF4EBP1/SESN3/BMPR2/SLC38A2/SLC39A4/FOXO3/PRKAA1/IFI16 10 GO:0002313 mature B cell differentiation involved in immune response 2/803 28/18722 0.339315879651802 0.606345156506934 LGALS1/NOTCH2 2 GO:0002507 tolerance induction 2/803 28/18722 0.339315879651802 0.606345156506934 HLA-B/TGFBR2 2 GO:0002675 positive regulation of acute inflammatory response 2/803 28/18722 0.339315879651802 0.606345156506934 OSMR/IL6ST 2 GO:0007064 mitotic sister chromatid cohesion 2/803 28/18722 0.339315879651802 0.606345156506934 PDS5B/ATRX 2 GO:0007271 synaptic transmission, cholinergic 2/803 28/18722 0.339315879651802 0.606345156506934 LAMA2/APOE 2 GO:0008299 isoprenoid biosynthetic process 2/803 28/18722 0.339315879651802 0.606345156506934 RBP1/RDH10 2 GO:0010818 T cell chemotaxis 2/803 28/18722 0.339315879651802 0.606345156506934 PLEC/WNK1 2 GO:0044331 cell-cell adhesion mediated by cadherin 2/803 28/18722 0.339315879651802 0.606345156506934 FER/TJP1 2 GO:0050996 positive regulation of lipid catabolic process 2/803 28/18722 0.339315879651802 0.606345156506934 IRS1/TWIST1 2 GO:0061082 myeloid leukocyte cytokine production 2/803 28/18722 0.339315879651802 0.606345156506934 SPON2/CD36 2 GO:0086011 membrane repolarization during action potential 2/803 28/18722 0.339315879651802 0.606345156506934 FLNA/ATP1B1 2 GO:1902624 positive regulation of neutrophil migration 2/803 28/18722 0.339315879651802 0.606345156506934 IL1R1/MDK 2 GO:1903649 regulation of cytoplasmic transport 2/803 28/18722 0.339315879651802 0.606345156506934 DAB2/MSN 2 GO:1903671 negative regulation of sprouting angiogenesis 2/803 28/18722 0.339315879651802 0.606345156506934 CREB3L1/THBS1 2 GO:0015804 neutral amino acid transport 3/803 48/18722 0.339537702267344 0.606345156506934 SERINC3/SLC38A2/SERINC5 3 GO:0032527 protein exit from endoplasmic reticulum 3/803 48/18722 0.339537702267344 0.606345156506934 CD81/HSP90B1/SAR1A 3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 3/803 48/18722 0.339537702267344 0.606345156506934 ATRX/FAM111A/NUCKS1 3 GO:0061647 histone H3-K9 modification 3/803 48/18722 0.339537702267344 0.606345156506934 KMT2A/ASH1L/ATRX 3 GO:0090199 regulation of release of cytochrome c from mitochondria 3/803 48/18722 0.339537702267344 0.606345156506934 HGF/CLU/PLAUR 3 GO:0097720 calcineurin-mediated signaling 3/803 48/18722 0.339537702267344 0.606345156506934 LMCD1/NFAT5/PRNP 3 GO:0030901 midbrain development 5/803 90/18722 0.343142092757603 0.606345156506934 WNT2/BASP1/LRP6/SOS1/ZNF148 5 GO:0045638 negative regulation of myeloid cell differentiation 5/803 90/18722 0.343142092757603 0.606345156506934 MEIS2/PIK3R1/ZFP36L1/FBN1/GPR137B 5 GO:0015807 L-amino acid transport 4/803 69/18722 0.343413039247927 0.606345156506934 SERINC3/ITGB1/SLC38A2/SERINC5 4 GO:0045665 negative regulation of neuron differentiation 4/803 69/18722 0.343413039247927 0.606345156506934 B2M/JAG1/FOXO3/MIB1 4 GO:0060193 positive regulation of lipase activity 4/803 69/18722 0.343413039247927 0.606345156506934 PDGFRA/PDGFRB/LPAR1/FGFR1 4 GO:0070192 chromosome organization involved in meiotic cell cycle 4/803 69/18722 0.343413039247927 0.606345156506934 MAEL/ATRX/P3H4/TERF1 4 GO:0043406 positive regulation of MAP kinase activity 6/803 112/18722 0.348732722997324 0.606345156506934 KITLG/PDGFRB/THBS1/FGFR1/ROBO1/AKAP13 6 GO:1901222 regulation of NIK/NF-kappaB signaling 6/803 112/18722 0.348732722997324 0.606345156506934 UACA/NFAT5/AGO3/LITAF/ACTN4/TSPAN6 6 GO:0002762 negative regulation of myeloid leukocyte differentiation 3/803 49/18722 0.351400915090233 0.606345156506934 PIK3R1/FBN1/GPR137B 3 GO:0006376 mRNA splice site selection 3/803 49/18722 0.351400915090233 0.606345156506934 CELF2/SETX/LUC7L3 3 GO:0006692 prostanoid metabolic process 3/803 49/18722 0.351400915090233 0.606345156506934 PTGDS/ZADH2/TNFRSF1A 3 GO:0006693 prostaglandin metabolic process 3/803 49/18722 0.351400915090233 0.606345156506934 PTGDS/ZADH2/TNFRSF1A 3 GO:0006778 porphyrin-containing compound metabolic process 3/803 49/18722 0.351400915090233 0.606345156506934 BDH2/TSPO/PGRMC1 3 GO:0007622 rhythmic behavior 3/803 49/18722 0.351400915090233 0.606345156506934 PTGDS/PTEN/ZFHX3 3 GO:0009994 oocyte differentiation 3/803 49/18722 0.351400915090233 0.606345156506934 PDE3A/CDC25B/FOXO3 3 GO:0010823 negative regulation of mitochondrion organization 3/803 49/18722 0.351400915090233 0.606345156506934 HGF/CLU/TSPO 3 GO:0030225 macrophage differentiation 3/803 49/18722 0.351400915090233 0.606345156506934 CSF1/BMP4/PRKCA 3 GO:0035088 establishment or maintenance of apical/basal cell polarity 3/803 49/18722 0.351400915090233 0.606345156506934 FSCN1/PTK7/MSN 3 GO:0042461 photoreceptor cell development 3/803 49/18722 0.351400915090233 0.606345156506934 THY1/TUG1/CEP290 3 GO:0043457 regulation of cellular respiration 3/803 49/18722 0.351400915090233 0.606345156506934 COX7A1/NUPR1/IFNAR1 3 GO:0061245 establishment or maintenance of bipolar cell polarity 3/803 49/18722 0.351400915090233 0.606345156506934 FSCN1/PTK7/MSN 3 GO:0072666 establishment of protein localization to vacuole 3/803 49/18722 0.351400915090233 0.606345156506934 CLU/SCARB2/SORT1 3 GO:1990928 response to amino acid starvation 3/803 49/18722 0.351400915090233 0.606345156506934 EIF4EBP1/SESN3/SLC38A2 3 GO:0001508 action potential 7/803 134/18722 0.352094909081339 0.606345156506934 CD36/GJA1/BIN1/FLNA/ATP1B1/CAMK2D/SLC8A1 7 GO:0000338 protein deneddylation 1/803 10/18722 0.354986965636032 0.606345156506934 COPS8 1 GO:0001553 luteinization 1/803 10/18722 0.354986965636032 0.606345156506934 PDGFRA 1 GO:0001865 NK T cell differentiation 1/803 10/18722 0.354986965636032 0.606345156506934 TGFBR2 1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1/803 10/18722 0.354986965636032 0.606345156506934 CD81 1 GO:0002524 hypersensitivity 1/803 10/18722 0.354986965636032 0.606345156506934 EXT1 1 GO:0003056 regulation of vascular associated smooth muscle contraction 1/803 10/18722 0.354986965636032 0.606345156506934 ZDHHC21 1 GO:0003163 sinoatrial node development 1/803 10/18722 0.354986965636032 0.606345156506934 BMP4 1 GO:0003330 regulation of extracellular matrix constituent secretion 1/803 10/18722 0.354986965636032 0.606345156506934 TNFRSF1A 1 GO:0006171 cAMP biosynthetic process 1/803 10/18722 0.354986965636032 0.606345156506934 ADCY3 1 GO:0006560 proline metabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 OAT 1 GO:0008300 isoprenoid catabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 CRABP1 1 GO:0010728 regulation of hydrogen peroxide biosynthetic process 1/803 10/18722 0.354986965636032 0.606345156506934 STAT3 1 GO:0014041 regulation of neuron maturation 1/803 10/18722 0.354986965636032 0.606345156506934 EDNRB 1 GO:0016139 glycoside catabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 FUCA2 1 GO:0017085 response to insecticide 1/803 10/18722 0.354986965636032 0.606345156506934 MAP1B 1 GO:0018242 protein O-linked glycosylation via serine 1/803 10/18722 0.354986965636032 0.606345156506934 GALNT1 1 GO:0021562 vestibulocochlear nerve development 1/803 10/18722 0.354986965636032 0.606345156506934 NRP2 1 GO:0031915 positive regulation of synaptic plasticity 1/803 10/18722 0.354986965636032 0.606345156506934 MAP1B 1 GO:0032025 response to cobalt ion 1/803 10/18722 0.354986965636032 0.606345156506934 SERPINF1 1 GO:0032525 somite rostral/caudal axis specification 1/803 10/18722 0.354986965636032 0.606345156506934 EPB41L5 1 GO:0033080 immature T cell proliferation in thymus 1/803 10/18722 0.354986965636032 0.606345156506934 BMP4 1 GO:0033572 transferrin transport 1/803 10/18722 0.354986965636032 0.606345156506934 CLTC 1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 1/803 10/18722 0.354986965636032 0.606345156506934 NNMT 1 GO:0034756 regulation of iron ion transport 1/803 10/18722 0.354986965636032 0.606345156506934 B2M 1 GO:0035520 monoubiquitinated protein deubiquitination 1/803 10/18722 0.354986965636032 0.606345156506934 USP47 1 GO:0035646 endosome to melanosome transport 1/803 10/18722 0.354986965636032 0.606345156506934 CD63 1 GO:0035768 endothelial cell chemotaxis to fibroblast growth factor 1/803 10/18722 0.354986965636032 0.606345156506934 FGFR1 1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 1/803 10/18722 0.354986965636032 0.606345156506934 SULF2 1 GO:0035907 dorsal aorta development 1/803 10/18722 0.354986965636032 0.606345156506934 ENG 1 GO:0036109 alpha-linolenic acid metabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 ELOVL2 1 GO:0040015 negative regulation of multicellular organism growth 1/803 10/18722 0.354986965636032 0.606345156506934 SOCS2 1 GO:0042045 epithelial fluid transport 1/803 10/18722 0.354986965636032 0.606345156506934 EDNRB 1 GO:0042368 vitamin D biosynthetic process 1/803 10/18722 0.354986965636032 0.606345156506934 SNAI2 1 GO:0042711 maternal behavior 1/803 10/18722 0.354986965636032 0.606345156506934 PTEN 1 GO:0042989 sequestering of actin monomers 1/803 10/18722 0.354986965636032 0.606345156506934 GSN 1 GO:0043485 endosome to pigment granule transport 1/803 10/18722 0.354986965636032 0.606345156506934 CD63 1 GO:0045792 negative regulation of cell size 1/803 10/18722 0.354986965636032 0.606345156506934 PTEN 1 GO:0045835 negative regulation of meiotic nuclear division 1/803 10/18722 0.354986965636032 0.606345156506934 PRKAR1A 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/803 10/18722 0.354986965636032 0.606345156506934 THRA 1 GO:0048241 epinephrine transport 1/803 10/18722 0.354986965636032 0.606345156506934 SLC22A3 1 GO:0048672 positive regulation of collateral sprouting 1/803 10/18722 0.354986965636032 0.606345156506934 LRP1 1 GO:0048703 embryonic viscerocranium morphogenesis 1/803 10/18722 0.354986965636032 0.606345156506934 RDH10 1 GO:0048755 branching morphogenesis of a nerve 1/803 10/18722 0.354986965636032 0.606345156506934 RTN4 1 GO:0048757 pigment granule maturation 1/803 10/18722 0.354986965636032 0.606345156506934 CD63 1 GO:0051351 positive regulation of ligase activity 1/803 10/18722 0.354986965636032 0.606345156506934 GCLM 1 GO:0051918 negative regulation of fibrinolysis 1/803 10/18722 0.354986965636032 0.606345156506934 THBS1 1 GO:0051974 negative regulation of telomerase activity 1/803 10/18722 0.354986965636032 0.606345156506934 TERF1 1 GO:0060068 vagina development 1/803 10/18722 0.354986965636032 0.606345156506934 AXL 1 GO:0060513 prostatic bud formation 1/803 10/18722 0.354986965636032 0.606345156506934 BMP4 1 GO:0060525 prostate glandular acinus development 1/803 10/18722 0.354986965636032 0.606345156506934 FRS2 1 GO:0060736 prostate gland growth 1/803 10/18722 0.354986965636032 0.606345156506934 PTEN 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/803 10/18722 0.354986965636032 0.606345156506934 SERPINF1 1 GO:0060947 cardiac vascular smooth muscle cell differentiation 1/803 10/18722 0.354986965636032 0.606345156506934 GATA6 1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 1/803 10/18722 0.354986965636032 0.606345156506934 MAP4K4 1 GO:0061299 retina vasculature morphogenesis in camera-type eye 1/803 10/18722 0.354986965636032 0.606345156506934 COL4A1 1 GO:0070391 response to lipoteichoic acid 1/803 10/18722 0.354986965636032 0.606345156506934 CD36 1 GO:0071073 positive regulation of phospholipid biosynthetic process 1/803 10/18722 0.354986965636032 0.606345156506934 CAPN2 1 GO:0071223 cellular response to lipoteichoic acid 1/803 10/18722 0.354986965636032 0.606345156506934 CD36 1 GO:0071233 cellular response to leucine 1/803 10/18722 0.354986965636032 0.606345156506934 SESN3 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/803 10/18722 0.354986965636032 0.606345156506934 GCLM 1 GO:0071600 otic vesicle morphogenesis 1/803 10/18722 0.354986965636032 0.606345156506934 CEP290 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/803 10/18722 0.354986965636032 0.606345156506934 BMP4 1 GO:0072378 blood coagulation, fibrin clot formation 1/803 10/18722 0.354986965636032 0.606345156506934 FBLN1 1 GO:0090043 regulation of tubulin deacetylation 1/803 10/18722 0.354986965636032 0.606345156506934 PRKAA1 1 GO:0090179 planar cell polarity pathway involved in neural tube closure 1/803 10/18722 0.354986965636032 0.606345156506934 PTK7 1 GO:0090209 negative regulation of triglyceride metabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 APOE 1 GO:0090527 actin filament reorganization 1/803 10/18722 0.354986965636032 0.606345156506934 GSN 1 GO:0097250 mitochondrial respirasome assembly 1/803 10/18722 0.354986965636032 0.606345156506934 COX7A1 1 GO:0098885 modification of postsynaptic actin cytoskeleton 1/803 10/18722 0.354986965636032 0.606345156506934 ITSN1 1 GO:0098903 regulation of membrane repolarization during action potential 1/803 10/18722 0.354986965636032 0.606345156506934 FLNA 1 GO:0099532 synaptic vesicle endosomal processing 1/803 10/18722 0.354986965636032 0.606345156506934 ITSN1 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/803 10/18722 0.354986965636032 0.606345156506934 CAPN2 1 GO:1900246 positive regulation of RIG-I signaling pathway 1/803 10/18722 0.354986965636032 0.606345156506934 PUM2 1 GO:1901725 regulation of histone deacetylase activity 1/803 10/18722 0.354986965636032 0.606345156506934 CAMK2D 1 GO:1901993 regulation of meiotic cell cycle phase transition 1/803 10/18722 0.354986965636032 0.606345156506934 CDC25B 1 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/803 10/18722 0.354986965636032 0.606345156506934 SERINC3 1 GO:1904526 regulation of microtubule binding 1/803 10/18722 0.354986965636032 0.606345156506934 ABL1 1 GO:1904668 positive regulation of ubiquitin protein ligase activity 1/803 10/18722 0.354986965636032 0.606345156506934 PTEN 1 GO:1905383 protein localization to presynapse 1/803 10/18722 0.354986965636032 0.606345156506934 HSPB1 1 GO:1905456 regulation of lymphoid progenitor cell differentiation 1/803 10/18722 0.354986965636032 0.606345156506934 SOS1 1 GO:1905651 regulation of artery morphogenesis 1/803 10/18722 0.354986965636032 0.606345156506934 MDK 1 GO:1990253 cellular response to leucine starvation 1/803 10/18722 0.354986965636032 0.606345156506934 SESN3 1 GO:1990535 neuron projection maintenance 1/803 10/18722 0.354986965636032 0.606345156506934 PRNP 1 GO:2000425 regulation of apoptotic cell clearance 1/803 10/18722 0.354986965636032 0.606345156506934 C2 1 GO:2000434 regulation of protein neddylation 1/803 10/18722 0.354986965636032 0.606345156506934 EPAS1 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/803 10/18722 0.354986965636032 0.606345156506934 GAS6 1 GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 1/803 10/18722 0.354986965636032 0.606345156506934 FGFR1 1 GO:2000659 regulation of interleukin-1-mediated signaling pathway 1/803 10/18722 0.354986965636032 0.606345156506934 IL1R1 1 GO:2000726 negative regulation of cardiac muscle cell differentiation 1/803 10/18722 0.354986965636032 0.606345156506934 FRS2 1 GO:2001225 regulation of chloride transport 1/803 10/18722 0.354986965636032 0.606345156506934 PRNP 1 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/803 10/18722 0.354986965636032 0.606345156506934 SRPX 1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/803 10/18722 0.354986965636032 0.606345156506934 GSN 1 GO:0007143 female meiotic nuclear division 2/803 29/18722 0.355099850982802 0.606345156506934 CDC25B/PRKAR1A 2 GO:0019082 viral protein processing 2/803 29/18722 0.355099850982802 0.606345156506934 GALNT1/CANX 2 GO:0019359 nicotinamide nucleotide biosynthetic process 2/803 29/18722 0.355099850982802 0.606345156506934 NNMT/NADK2 2 GO:0019363 pyridine nucleotide biosynthetic process 2/803 29/18722 0.355099850982802 0.606345156506934 NNMT/NADK2 2 GO:0034311 diol metabolic process 2/803 29/18722 0.355099850982802 0.606345156506934 PLPP1/PLPP3 2 GO:0040018 positive regulation of multicellular organism growth 2/803 29/18722 0.355099850982802 0.606345156506934 CSF1/IGF2 2 GO:0051654 establishment of mitochondrion localization 2/803 29/18722 0.355099850982802 0.606345156506934 MAP1B/ARMCX3 2 GO:0070198 protein localization to chromosome, telomeric region 2/803 29/18722 0.355099850982802 0.606345156506934 ATRX/TERF1 2 GO:0071549 cellular response to dexamethasone stimulus 2/803 29/18722 0.355099850982802 0.606345156506934 SERPINF1/NR3C1 2 GO:0090114 COPII-coated vesicle budding 2/803 29/18722 0.355099850982802 0.606345156506934 SEC31A/SAR1A 2 GO:1900117 regulation of execution phase of apoptosis 2/803 29/18722 0.355099850982802 0.606345156506934 FAP/DLC1 2 GO:1903902 positive regulation of viral life cycle 2/803 29/18722 0.355099850982802 0.606345156506934 LGALS1/AXL 2 GO:0002708 positive regulation of lymphocyte mediated immunity 6/803 113/18722 0.356422291935066 0.608394915298951 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F 6 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 17/803 356/18722 0.359588813068424 0.613589945913471 C7/C1R/C1S/IL1R1/TMEM98/C2/HLA-B/SERPING1/HLA-A/CD81/B2M/CLU/HLA-F/JAG1/STAT3/NDFIP1/BTN3A2 17 GO:0007034 vacuolar transport 8/803 157/18722 0.360598819496844 0.615102878553289 BIN1/TMEM106B/LRP1/CLU/SCARB2/IGF2R/SORT1/NDFIP1 8 GO:0070588 calcium ion transmembrane transport 15/803 312/18722 0.362309234583839 0.617704634085869 THY1/GAS6/BIN1/HSPA2/ATP1B1/CAMK2D/PKD1/PKD2/SEC61A1/PRNP/AHNAK/SESTD1/ABL1/TPCN1/SLC8A1 15 GO:0000281 mitotic cytokinesis 4/803 71/18722 0.363092800012934 0.617704634085869 SPTBN1/SON/ROCK2/MAP9 4 GO:0002228 natural killer cell mediated immunity 4/803 71/18722 0.363092800012934 0.617704634085869 HLA-B/HLA-A/HLA-F/SERPINB9 4 GO:0007632 visual behavior 3/803 50/18722 0.363239066815035 0.617704634085869 MEIS2/ITGB1/NPTN 3 GO:0019083 viral transcription 3/803 50/18722 0.363239066815035 0.617704634085869 IFITM3/RSF1/NUCKS1 3 GO:0038093 Fc receptor signaling pathway 3/803 50/18722 0.363239066815035 0.617704634085869 ABL1/FER/SOS1 3 GO:0038202 TORC1 signaling 3/803 50/18722 0.363239066815035 0.617704634085869 SESN3/GPR137B/ATM 3 GO:1903747 regulation of establishment of protein localization to mitochondrion 3/803 50/18722 0.363239066815035 0.617704634085869 NPEPPS/PRKAA1/BNIP3L 3 GO:2000677 regulation of transcription regulatory region DNA binding 3/803 50/18722 0.363239066815035 0.617704634085869 HAND2/TWIST1/KLF4 3 GO:1903046 meiotic cell cycle process 10/803 202/18722 0.367132669278303 0.622231772075991 PDE3A/MAEL/HSPA2/PLCB1/CDC25B/PRKAR1A/ATRX/P3H4/TERF1/ATM 10 GO:0007589 body fluid secretion 5/803 93/18722 0.368875137077256 0.622231772075991 PRLR/NCOR2/SOCS2/WNK1/NCOA1 5 GO:1901019 regulation of calcium ion transmembrane transporter activity 5/803 93/18722 0.368875137077256 0.622231772075991 HSPA2/ATP1B1/CAMK2D/PKD2/AHNAK 5 GO:1901796 regulation of signal transduction by p53 class mediator 5/803 93/18722 0.368875137077256 0.622231772075991 SNAI2/TWIST1/SPRED1/PLA2R1/ATM 5 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/803 30/18722 0.37074703296187 0.622231772075991 CAMK2D/SLC8A1 2 GO:0033137 negative regulation of peptidyl-serine phosphorylation 2/803 30/18722 0.37074703296187 0.622231772075991 HGF/PTEN 2 GO:0045577 regulation of B cell differentiation 2/803 30/18722 0.37074703296187 0.622231772075991 ZFP36L2/ZFP36L1 2 GO:0048147 negative regulation of fibroblast proliferation 2/803 30/18722 0.37074703296187 0.622231772075991 NUPR1/SKI 2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 2/803 30/18722 0.37074703296187 0.622231772075991 THY1/PRNP 2 GO:0070498 interleukin-1-mediated signaling pathway 2/803 30/18722 0.37074703296187 0.622231772075991 IL1R1/PLCB1 2 GO:0099068 postsynapse assembly 2/803 30/18722 0.37074703296187 0.622231772075991 PTPRD/PTEN 2 GO:1902751 positive regulation of cell cycle G2/M phase transition 2/803 30/18722 0.37074703296187 0.622231772075991 HSPA2/CDC25B 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/803 30/18722 0.37074703296187 0.622231772075991 SLC2A10/TMEM59 2 GO:0034968 histone lysine methylation 6/803 115/18722 0.371832548580524 0.622231772075991 NNMT/KMT2A/ASH1L/ATRX/KMT2E/RTF1 6 GO:0051209 release of sequestered calcium ion into cytosol 6/803 115/18722 0.371832548580524 0.622231772075991 THY1/CAMK2D/PKD2/ABL1/TPCN1/SLC8A1 6 GO:1901989 positive regulation of cell cycle phase transition 6/803 115/18722 0.371832548580524 0.622231772075991 CCND2/ADAMTS1/HSPA2/PLCB1/CDC25B/KMT2E 6 GO:0032729 positive regulation of interferon-gamma production 4/803 72/18722 0.372926762082239 0.622231772075991 IL1R1/HLA-A/ABL1/BTN3A2 4 GO:0050671 positive regulation of lymphocyte proliferation 7/803 137/18722 0.373224799989909 0.622231772075991 IGFBP2/VCAM1/IL6ST/IGF2/HLA-A/CD81/TGFBR2 7 GO:0006636 unsaturated fatty acid biosynthetic process 3/803 51/18722 0.375042136899122 0.622231772075991 PTGDS/ELOVL2/FADS3 3 GO:0021872 forebrain generation of neurons 3/803 51/18722 0.375042136899122 0.622231772075991 NRP2/B2M/ZMIZ1 3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 3/803 51/18722 0.375042136899122 0.622231772075991 ABL1/ASH1L/ZMYND11 3 GO:0051293 establishment of spindle localization 3/803 51/18722 0.375042136899122 0.622231772075991 GJA1/SPRY1/ITGB1 3 GO:0051339 regulation of lyase activity 3/803 51/18722 0.375042136899122 0.622231772075991 PALM/EDNRB/TIMP2 3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 5/803 94/18722 0.37746159245786 0.622231772075991 CCND2/CCNG2/PTEN/PKD1/PKD2 5 GO:0019080 viral gene expression 5/803 94/18722 0.37746159245786 0.622231772075991 IFITM3/RSF1/GALNT1/NUCKS1/CANX 5 GO:0051702 biological process involved in interaction with symbiont 5/803 94/18722 0.37746159245786 0.622231772075991 APOE/APOL1/IGF2R/STOM/NUCKS1 5 GO:0018209 peptidyl-serine modification 16/803 338/18722 0.378869232327143 0.622231772075991 DCN/HGF/GAS6/ANGPT1/PRKCA/PTEN/CAMK2D/PKD1/ROCK2/TGFBR2/HIPK3/WNK1/GALNT1/PRKAA1/HIPK1/ATM 16 GO:0006720 isoprenoid metabolic process 6/803 116/18722 0.379547017080252 0.622231772075991 RARRES2/RBP1/CRABP1/RDH10/LRP1/NPC2 6 GO:0051283 negative regulation of sequestering of calcium ion 6/803 116/18722 0.379547017080252 0.622231772075991 THY1/CAMK2D/PKD2/ABL1/TPCN1/SLC8A1 6 GO:0009260 ribonucleotide biosynthetic process 9/803 182/18722 0.379622538094827 0.622231772075991 GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/PID1/STAT3/PANK3/PAPSS1 9 GO:0035637 multicellular organismal signaling 8/803 160/18722 0.380213289938693 0.622231772075991 NFASC/GJA1/BIN1/FLNA/ATP1B1/CAMK2D/PLEC/SLC8A1 8 GO:0001660 fever generation 1/803 11/18722 0.382666821696008 0.622231772075991 EDNRB 1 GO:0002604 regulation of dendritic cell antigen processing and presentation 1/803 11/18722 0.382666821696008 0.622231772075991 THBS1 1 GO:0002645 positive regulation of tolerance induction 1/803 11/18722 0.382666821696008 0.622231772075991 TGFBR2 1 GO:0002725 negative regulation of T cell cytokine production 1/803 11/18722 0.382666821696008 0.622231772075991 HLA-F 1 GO:0002759 regulation of antimicrobial humoral response 1/803 11/18722 0.382666821696008 0.622231772075991 GATA6 1 GO:0003139 secondary heart field specification 1/803 11/18722 0.382666821696008 0.622231772075991 BMP4 1 GO:0003263 cardioblast proliferation 1/803 11/18722 0.382666821696008 0.622231772075991 HAND2 1 GO:0003264 regulation of cardioblast proliferation 1/803 11/18722 0.382666821696008 0.622231772075991 HAND2 1 GO:0006020 inositol metabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 SLC5A3 1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/803 11/18722 0.382666821696008 0.622231772075991 PDK4 1 GO:0006182 cGMP biosynthetic process 1/803 11/18722 0.382666821696008 0.622231772075991 GUCY1A2 1 GO:0006707 cholesterol catabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 APOE 1 GO:0007042 lysosomal lumen acidification 1/803 11/18722 0.382666821696008 0.622231772075991 TMEM106B 1 GO:0007144 female meiosis I 1/803 11/18722 0.382666821696008 0.622231772075991 CDC25B 1 GO:0008611 ether lipid biosynthetic process 1/803 11/18722 0.382666821696008 0.622231772075991 LPCAT2 1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/803 11/18722 0.382666821696008 0.622231772075991 ATP1B1 1 GO:0010739 positive regulation of protein kinase A signaling 1/803 11/18722 0.382666821696008 0.622231772075991 AKAP12 1 GO:0010887 negative regulation of cholesterol storage 1/803 11/18722 0.382666821696008 0.622231772075991 CES1 1 GO:0014820 tonic smooth muscle contraction 1/803 11/18722 0.382666821696008 0.622231772075991 MYLK 1 GO:0015937 coenzyme A biosynthetic process 1/803 11/18722 0.382666821696008 0.622231772075991 PANK3 1 GO:0016127 sterol catabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 APOE 1 GO:0018342 protein prenylation 1/803 11/18722 0.382666821696008 0.622231772075991 CHML 1 GO:0021561 facial nerve development 1/803 11/18722 0.382666821696008 0.622231772075991 NRP2 1 GO:0021604 cranial nerve structural organization 1/803 11/18722 0.382666821696008 0.622231772075991 NRP2 1 GO:0021610 facial nerve morphogenesis 1/803 11/18722 0.382666821696008 0.622231772075991 NRP2 1 GO:0021860 pyramidal neuron development 1/803 11/18722 0.382666821696008 0.622231772075991 ZMIZ1 1 GO:0030432 peristalsis 1/803 11/18722 0.382666821696008 0.622231772075991 TBX2 1 GO:0032276 regulation of gonadotropin secretion 1/803 11/18722 0.382666821696008 0.622231772075991 GJA1 1 GO:0032493 response to bacterial lipoprotein 1/803 11/18722 0.382666821696008 0.622231772075991 CD36 1 GO:0032957 inositol trisphosphate metabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 IPMK 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/803 11/18722 0.382666821696008 0.622231772075991 KITLG 1 GO:0033083 regulation of immature T cell proliferation 1/803 11/18722 0.382666821696008 0.622231772075991 BMP4 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 YAP1 1 GO:0033197 response to vitamin E 1/803 11/18722 0.382666821696008 0.622231772075991 COL1A1 1 GO:0033210 leptin-mediated signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 STAT3 1 GO:0033327 Leydig cell differentiation 1/803 11/18722 0.382666821696008 0.622231772075991 PDGFRA 1 GO:0033625 positive regulation of integrin activation 1/803 11/18722 0.382666821696008 0.622231772075991 PIEZO1 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 RTN4 1 GO:0034454 microtubule anchoring at centrosome 1/803 11/18722 0.382666821696008 0.622231772075991 NIN 1 GO:0035404 histone-serine phosphorylation 1/803 11/18722 0.382666821696008 0.622231772075991 PRKAA1 1 GO:0035581 sequestering of extracellular ligand from receptor 1/803 11/18722 0.382666821696008 0.622231772075991 FBN1 1 GO:0035766 cell chemotaxis to fibroblast growth factor 1/803 11/18722 0.382666821696008 0.622231772075991 FGFR1 1 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 TSPAN6 1 GO:0042447 hormone catabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 ECE1 1 GO:0042670 retinal cone cell differentiation 1/803 11/18722 0.382666821696008 0.622231772075991 THY1 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/803 11/18722 0.382666821696008 0.622231772075991 EPAS1 1 GO:0044068 modulation by symbiont of host cellular process 1/803 11/18722 0.382666821696008 0.622231772075991 SERPINB9 1 GO:0044771 meiotic cell cycle phase transition 1/803 11/18722 0.382666821696008 0.622231772075991 CDC25B 1 GO:0045161 neuronal ion channel clustering 1/803 11/18722 0.382666821696008 0.622231772075991 NRCAM 1 GO:0046504 glycerol ether biosynthetic process 1/803 11/18722 0.382666821696008 0.622231772075991 LPCAT2 1 GO:0046549 retinal cone cell development 1/803 11/18722 0.382666821696008 0.622231772075991 THY1 1 GO:0046598 positive regulation of viral entry into host cell 1/803 11/18722 0.382666821696008 0.622231772075991 LGALS1 1 GO:0048096 chromatin-mediated maintenance of transcription 1/803 11/18722 0.382666821696008 0.622231772075991 ZMIZ1 1 GO:0048103 somatic stem cell division 1/803 11/18722 0.382666821696008 0.622231772075991 ZFP36L2 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/803 11/18722 0.382666821696008 0.622231772075991 TMEM98 1 GO:0048853 forebrain morphogenesis 1/803 11/18722 0.382666821696008 0.622231772075991 PTEN 1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 SPRY1 1 GO:0051610 serotonin uptake 1/803 11/18722 0.382666821696008 0.622231772075991 SLC22A3 1 GO:0051657 maintenance of organelle location 1/803 11/18722 0.382666821696008 0.622231772075991 ARHGAP21 1 GO:0051798 positive regulation of hair follicle development 1/803 11/18722 0.382666821696008 0.622231772075991 FST 1 GO:0060159 regulation of dopamine receptor signaling pathway 1/803 11/18722 0.382666821696008 0.622231772075991 PALM 1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/803 11/18722 0.382666821696008 0.622231772075991 PKD2 1 GO:0060746 parental behavior 1/803 11/18722 0.382666821696008 0.622231772075991 PTEN 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/803 11/18722 0.382666821696008 0.622231772075991 SERPINF1 1 GO:0070203 regulation of establishment of protein localization to telomere 1/803 11/18722 0.382666821696008 0.622231772075991 TERF1 1 GO:0070243 regulation of thymocyte apoptotic process 1/803 11/18722 0.382666821696008 0.622231772075991 BMP4 1 GO:0070327 thyroid hormone transport 1/803 11/18722 0.382666821696008 0.622231772075991 SLC16A10 1 GO:0070341 fat cell proliferation 1/803 11/18722 0.382666821696008 0.622231772075991 PID1 1 GO:0070344 regulation of fat cell proliferation 1/803 11/18722 0.382666821696008 0.622231772075991 PID1 1 GO:0071044 histone mRNA catabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 ATM 1 GO:0071313 cellular response to caffeine 1/803 11/18722 0.382666821696008 0.622231772075991 SLC8A1 1 GO:0071679 commissural neuron axon guidance 1/803 11/18722 0.382666821696008 0.622231772075991 NFIB 1 GO:0072173 metanephric tubule morphogenesis 1/803 11/18722 0.382666821696008 0.622231772075991 PKD1 1 GO:0075294 positive regulation by symbiont of entry into host 1/803 11/18722 0.382666821696008 0.622231772075991 LGALS1 1 GO:0075733 intracellular transport of virus 1/803 11/18722 0.382666821696008 0.622231772075991 BST2 1 GO:0090084 negative regulation of inclusion body assembly 1/803 11/18722 0.382666821696008 0.622231772075991 HSPA2 1 GO:0090160 Golgi to lysosome transport 1/803 11/18722 0.382666821696008 0.622231772075991 SORT1 1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1/803 11/18722 0.382666821696008 0.622231772075991 PTK7 1 GO:0090394 negative regulation of excitatory postsynaptic potential 1/803 11/18722 0.382666821696008 0.622231772075991 PTEN 1 GO:0090657 telomeric loop disassembly 1/803 11/18722 0.382666821696008 0.622231772075991 TERF1 1 GO:0097354 prenylation 1/803 11/18722 0.382666821696008 0.622231772075991 CHML 1 GO:0097384 cellular lipid biosynthetic process 1/803 11/18722 0.382666821696008 0.622231772075991 LPCAT2 1 GO:0098935 dendritic transport 1/803 11/18722 0.382666821696008 0.622231772075991 PURA 1 GO:0099550 trans-synaptic signaling, modulating synaptic transmission 1/803 11/18722 0.382666821696008 0.622231772075991 NPTN 1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 1/803 11/18722 0.382666821696008 0.622231772075991 SLC8A1 1 GO:0099624 atrial cardiac muscle cell membrane repolarization 1/803 11/18722 0.382666821696008 0.622231772075991 FLNA 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/803 11/18722 0.382666821696008 0.622231772075991 ATRX 1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 1/803 11/18722 0.382666821696008 0.622231772075991 CD36 1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 1/803 11/18722 0.382666821696008 0.622231772075991 N4BP2L2 1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1/803 11/18722 0.382666821696008 0.622231772075991 CAMK2D 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/803 11/18722 0.382666821696008 0.622231772075991 TNFRSF1A 1 GO:1902667 regulation of axon guidance 1/803 11/18722 0.382666821696008 0.622231772075991 SLIT2 1 GO:1903961 positive regulation of anion transmembrane transport 1/803 11/18722 0.382666821696008 0.622231772075991 ITGB1 1 GO:1904847 regulation of cell chemotaxis to fibroblast growth factor 1/803 11/18722 0.382666821696008 0.622231772075991 FGFR1 1 GO:1905522 negative regulation of macrophage migration 1/803 11/18722 0.382666821696008 0.622231772075991 EMILIN1 1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1/803 11/18722 0.382666821696008 0.622231772075991 CREB3L1 1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/803 11/18722 0.382666821696008 0.622231772075991 TJP1 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/803 11/18722 0.382666821696008 0.622231772075991 LRP1 1 GO:2000615 regulation of histone H3-K9 acetylation 1/803 11/18722 0.382666821696008 0.622231772075991 KMT2A 1 GO:2000644 regulation of receptor catabolic process 1/803 11/18722 0.382666821696008 0.622231772075991 APOE 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/803 11/18722 0.382666821696008 0.622231772075991 HOXA13 1 GO:0032732 positive regulation of interleukin-1 production 4/803 73/18722 0.382748665254125 0.622231772075991 CD36/STAT3/IFI16/HSPB1 4 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 4/803 73/18722 0.382748665254125 0.622231772075991 CAMK2N1/LRP1/SIDT2/MAP4K4 4 GO:0050848 regulation of calcium-mediated signaling 4/803 73/18722 0.382748665254125 0.622231772075991 CMKLR1/LMCD1/NFAT5/PRNP 4 GO:0051251 positive regulation of lymphocyte activation 17/803 362/18722 0.385600581058169 0.623435832592163 IGFBP2/VCAM1/THY1/GAS6/IL6ST/IGF2/LGALS1/HLA-A/CD81/MDK/AXL/DPP4/B2M/TGFBR2/MAP3K8/HLA-F/ZMIZ1 17 GO:0048709 oligodendrocyte differentiation 5/803 95/18722 0.386045487041284 0.623435832592163 TMEM98/CD9/PTEN/MDK/CLU 5 GO:0001782 B cell homeostasis 2/803 31/18722 0.386240129738707 0.623435832592163 ABL1/SOS1 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/803 31/18722 0.386240129738707 0.623435832592163 TSPO/PGRMC1 2 GO:0030212 hyaluronan metabolic process 2/803 31/18722 0.386240129738707 0.623435832592163 HGF/CLTC 2 GO:0031063 regulation of histone deacetylation 2/803 31/18722 0.386240129738707 0.623435832592163 CAMK2D/SKI 2 GO:0031114 regulation of microtubule depolymerization 2/803 31/18722 0.386240129738707 0.623435832592163 MAP1B/TAOK1 2 GO:0032148 activation of protein kinase B activity 2/803 31/18722 0.386240129738707 0.623435832592163 GAS6/CCDC88A 2 GO:0032509 endosome transport via multivesicular body sorting pathway 2/803 31/18722 0.386240129738707 0.623435832592163 LAPTM4B/SORT1 2 GO:0033014 tetrapyrrole biosynthetic process 2/803 31/18722 0.386240129738707 0.623435832592163 TSPO/PGRMC1 2 GO:0036474 cell death in response to hydrogen peroxide 2/803 31/18722 0.386240129738707 0.623435832592163 HGF/FOXO3 2 GO:0050482 arachidonic acid secretion 2/803 31/18722 0.386240129738707 0.623435832592163 PLA2G2A/PLA2R1 2 GO:0055075 potassium ion homeostasis 2/803 31/18722 0.386240129738707 0.623435832592163 KCNMA1/ATP1B1 2 GO:0065005 protein-lipid complex assembly 2/803 31/18722 0.386240129738707 0.623435832592163 APOE/BIN1 2 GO:0090162 establishment of epithelial cell polarity 2/803 31/18722 0.386240129738707 0.623435832592163 PTK7/MSN 2 GO:0090183 regulation of kidney development 2/803 31/18722 0.386240129738707 0.623435832592163 BMP4/BASP1 2 GO:0097106 postsynaptic density organization 2/803 31/18722 0.386240129738707 0.623435832592163 PTPRD/PTEN 2 GO:1901797 negative regulation of signal transduction by p53 class mediator 2/803 31/18722 0.386240129738707 0.623435832592163 SNAI2/TWIST1 2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/803 31/18722 0.386240129738707 0.623435832592163 HGF/BMP5 2 GO:1903963 arachidonate transport 2/803 31/18722 0.386240129738707 0.623435832592163 PLA2G2A/PLA2R1 2 GO:1905144 response to acetylcholine 2/803 31/18722 0.386240129738707 0.623435832592163 ROCK2/PLCB1 2 GO:1905145 cellular response to acetylcholine 2/803 31/18722 0.386240129738707 0.623435832592163 ROCK2/PLCB1 2 GO:0021545 cranial nerve development 3/803 52/18722 0.38680059450839 0.623734723227307 EXT1/NRP2/NAV2 3 GO:0032206 positive regulation of telomere maintenance 3/803 52/18722 0.38680059450839 0.623734723227307 ATRX/NEK7/ATM 3 GO:0043392 negative regulation of DNA binding 3/803 52/18722 0.38680059450839 0.623734723227307 HAND2/RSF1/IFI16 3 GO:0006801 superoxide metabolic process 4/803 74/18722 0.392552661583399 0.632192367782567 FBLN5/CD36/SOD3/SH3PXD2A 4 GO:0030968 endoplasmic reticulum unfolded protein response 4/803 74/18722 0.392552661583399 0.632192367782567 CREB3L1/PIK3R1/AMFR/MBTPS1 4 GO:0046470 phosphatidylcholine metabolic process 4/803 74/18722 0.392552661583399 0.632192367782567 ENPP2/PLA2G2A/LPCAT2/CAPN2 4 GO:1903201 regulation of oxidative stress-induced cell death 4/803 74/18722 0.392552661583399 0.632192367782567 HGF/GATA4/FOXO3/HSPB1 4 GO:0021953 central nervous system neuron differentiation 8/803 162/18722 0.393324299763254 0.633230532327925 CDH11/SLIT2/NFIB/PTEN/NRP2/B2M/NIN/ZMIZ1 8 GO:0015914 phospholipid transport 5/803 96/18722 0.394622788199974 0.634870245277727 PLSCR4/APOE/PLTP/SCARB2/NPC2 5 GO:0034620 cellular response to unfolded protein 5/803 96/18722 0.394622788199974 0.634870245277727 CREB3L1/HSPA2/PIK3R1/AMFR/MBTPS1 5 GO:0009308 amine metabolic process 6/803 118/18722 0.394979442609609 0.634870245277727 VCAM1/HAND2/NNMT/SLC22A3/INMT/EPAS1 6 GO:0051282 regulation of sequestering of calcium ion 6/803 118/18722 0.394979442609609 0.634870245277727 THY1/CAMK2D/PKD2/ABL1/TPCN1/SLC8A1 6 GO:0071346 cellular response to interferon-gamma 6/803 118/18722 0.394979442609609 0.634870245277727 CLDN1/VIM/IFNGR2/DAPK1/MYO1C/JAK1 6 GO:0045017 glycerolipid biosynthetic process 12/803 252/18722 0.397159349541426 0.637323651321742 PTEN/PIK3R1/SOCS2/CISH/LPGAT1/AGPAT2/LPCAT2/SOCS3/LPIN1/CAPN2/ATM/IPMK 12 GO:0140013 meiotic nuclear division 9/803 185/18722 0.398047949604701 0.637323651321742 PDE3A/MAEL/HSPA2/PLCB1/CDC25B/PRKAR1A/P3H4/TERF1/ATM 9 GO:0031279 regulation of cyclase activity 3/803 53/18722 0.398505392739601 0.637323651321742 PALM/EDNRB/TIMP2 3 GO:0032210 regulation of telomere maintenance via telomerase 3/803 53/18722 0.398505392739601 0.637323651321742 TERF1/NEK7/ATM 3 GO:0034381 plasma lipoprotein particle clearance 3/803 53/18722 0.398505392739601 0.637323651321742 CD36/APOE/VLDLR 3 GO:0043620 regulation of DNA-templated transcription in response to stress 3/803 53/18722 0.398505392739601 0.637323651321742 CREB3L1/EPAS1/BACH1 3 GO:1903202 negative regulation of oxidative stress-induced cell death 3/803 53/18722 0.398505392739601 0.637323651321742 HGF/GATA4/HSPB1 3 GO:2000772 regulation of cellular senescence 3/803 53/18722 0.398505392739601 0.637323651321742 B2M/TWIST1/ABL1 3 GO:0016042 lipid catabolic process 15/803 320/18722 0.399484863223067 0.637323651321742 RARRES2/ENPP2/PLA2G2A/CRABP1/APOE/CES1/BDH2/THRA/IRS1/PDE3B/LRP1/PLCB1/TWIST1/LPIN1/PRKAA1 15 GO:0016571 histone methylation 7/803 141/18722 0.401487031593975 0.637323651321742 NNMT/PRDM6/KMT2A/ASH1L/ATRX/KMT2E/RTF1 7 GO:0010039 response to iron ion 2/803 32/18722 0.40156357692624 0.637323651321742 CYBRD1/B2M 2 GO:0042044 fluid transport 2/803 32/18722 0.40156357692624 0.637323651321742 EDNRB/EXT1 2 GO:0071875 adrenergic receptor signaling pathway 2/803 32/18722 0.40156357692624 0.637323651321742 ZDHHC21/AKAP13 2 GO:0072337 modified amino acid transport 2/803 32/18722 0.40156357692624 0.637323651321742 GJA1/SLC38A2 2 GO:0072525 pyridine-containing compound biosynthetic process 2/803 32/18722 0.40156357692624 0.637323651321742 NNMT/NADK2 2 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/803 32/18722 0.40156357692624 0.637323651321742 CREB3L1/SERINC3 2 GO:1903955 positive regulation of protein targeting to mitochondrion 2/803 32/18722 0.40156357692624 0.637323651321742 NPEPPS/PRKAA1 2 GO:2000191 regulation of fatty acid transport 2/803 32/18722 0.40156357692624 0.637323651321742 THBS1/PLA2R1 2 GO:0008088 axo-dendritic transport 4/803 75/18722 0.402333095882596 0.637323651321742 DST/PURA/ARMCX3/HSPB1 4 GO:0034121 regulation of toll-like receptor signaling pathway 4/803 75/18722 0.402333095882596 0.637323651321742 CD36/MFHAS1/RTN4/PJA2 4 GO:0045913 positive regulation of carbohydrate metabolic process 4/803 75/18722 0.402333095882596 0.637323651321742 NNMT/IGF2/IRS1/PRKAA1 4 GO:0006721 terpenoid metabolic process 5/803 97/18722 0.403189557889307 0.637323651321742 RARRES2/RBP1/CRABP1/RDH10/LRP1 5 GO:0043255 regulation of carbohydrate biosynthetic process 5/803 97/18722 0.403189557889307 0.637323651321742 ENPP1/NNMT/IGF2/IRS1/CLTC 5 GO:0050806 positive regulation of synaptic transmission 8/803 164/18722 0.40644563391663 0.637323651321742 LAMA2/SERPINE2/APOE/PTEN/PRNP/ABL1/NPTN/CLSTN1 8 GO:0097553 calcium ion transmembrane import into cytosol 7/803 142/18722 0.408552999203425 0.637323651321742 THY1/CAMK2D/PKD2/PRNP/ABL1/TPCN1/SLC8A1 7 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/803 12/18722 0.409160250276954 0.637323651321742 NAV2 1 GO:0002328 pro-B cell differentiation 1/803 12/18722 0.409160250276954 0.637323651321742 SOS1 1 GO:0002424 T cell mediated immune response to tumor cell 1/803 12/18722 0.409160250276954 0.637323651321742 HLA-A 1 GO:0002674 negative regulation of acute inflammatory response 1/803 12/18722 0.409160250276954 0.637323651321742 ASH1L 1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/803 12/18722 0.409160250276954 0.637323651321742 CD81 1 GO:0006534 cysteine metabolic process 1/803 12/18722 0.409160250276954 0.637323651321742 GCLM 1 GO:0006703 estrogen biosynthetic process 1/803 12/18722 0.409160250276954 0.637323651321742 HSD17B2 1 GO:0008228 opsonization 1/803 12/18722 0.409160250276954 0.637323651321742 SPON2 1 GO:0010459 negative regulation of heart rate 1/803 12/18722 0.409160250276954 0.637323651321742 SPX 1 GO:0010587 miRNA catabolic process 1/803 12/18722 0.409160250276954 0.637323651321742 KCNQ1OT1 1 GO:0010623 programmed cell death involved in cell development 1/803 12/18722 0.409160250276954 0.637323651321742 KITLG 1 GO:0021978 telencephalon regionalization 1/803 12/18722 0.409160250276954 0.637323651321742 BMP4 1 GO:0030157 pancreatic juice secretion 1/803 12/18722 0.409160250276954 0.637323651321742 WNK1 1 GO:0032096 negative regulation of response to food 1/803 12/18722 0.409160250276954 0.637323651321742 SPX 1 GO:0032099 negative regulation of appetite 1/803 12/18722 0.409160250276954 0.637323651321742 SPX 1 GO:0032105 negative regulation of response to extracellular stimulus 1/803 12/18722 0.409160250276954 0.637323651321742 SPX 1 GO:0032108 negative regulation of response to nutrient levels 1/803 12/18722 0.409160250276954 0.637323651321742 SPX 1 GO:0033004 negative regulation of mast cell activation 1/803 12/18722 0.409160250276954 0.637323651321742 FER 1 GO:0033079 immature T cell proliferation 1/803 12/18722 0.409160250276954 0.637323651321742 BMP4 1 GO:0033127 regulation of histone phosphorylation 1/803 12/18722 0.409160250276954 0.637323651321742 TWIST1 1 GO:0034086 maintenance of sister chromatid cohesion 1/803 12/18722 0.409160250276954 0.637323651321742 ATRX 1 GO:0034088 maintenance of mitotic sister chromatid cohesion 1/803 12/18722 0.409160250276954 0.637323651321742 ATRX 1 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1/803 12/18722 0.409160250276954 0.637323651321742 APOE 1 GO:0034372 very-low-density lipoprotein particle remodeling 1/803 12/18722 0.409160250276954 0.637323651321742 APOE 1 GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/803 12/18722 0.409160250276954 0.637323651321742 LRP6 1 GO:0038203 TORC2 signaling 1/803 12/18722 0.409160250276954 0.637323651321742 SESN3 1 GO:0042117 monocyte activation 1/803 12/18722 0.409160250276954 0.637323651321742 CSF1 1 GO:0042762 regulation of sulfur metabolic process 1/803 12/18722 0.409160250276954 0.637323651321742 PDK4 1 GO:0043129 surfactant homeostasis 1/803 12/18722 0.409160250276954 0.637323651321742 EPAS1 1 GO:0043301 negative regulation of leukocyte degranulation 1/803 12/18722 0.409160250276954 0.637323651321742 HLA-F 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/803 12/18722 0.409160250276954 0.637323651321742 SCARB2 1 GO:0043476 pigment accumulation 1/803 12/18722 0.409160250276954 0.637323651321742 CD63 1 GO:0043482 cellular pigment accumulation 1/803 12/18722 0.409160250276954 0.637323651321742 CD63 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/803 12/18722 0.409160250276954 0.637323651321742 IGFBP5 1 GO:0045117 azole transmembrane transport 1/803 12/18722 0.409160250276954 0.637323651321742 SLC19A3 1 GO:0045602 negative regulation of endothelial cell differentiation 1/803 12/18722 0.409160250276954 0.637323651321742 JAG1 1 GO:0048548 regulation of pinocytosis 1/803 12/18722 0.409160250276954 0.637323651321742 AXL 1 GO:0048934 peripheral nervous system neuron differentiation 1/803 12/18722 0.409160250276954 0.637323651321742 HAND2 1 GO:0048935 peripheral nervous system neuron development 1/803 12/18722 0.409160250276954 0.637323651321742 HAND2 1 GO:0051340 regulation of ligase activity 1/803 12/18722 0.409160250276954 0.637323651321742 GCLM 1 GO:0051639 actin filament network formation 1/803 12/18722 0.409160250276954 0.637323651321742 PLS3 1 GO:0060019 radial glial cell differentiation 1/803 12/18722 0.409160250276954 0.637323651321742 STAT3 1 GO:0060123 regulation of growth hormone secretion 1/803 12/18722 0.409160250276954 0.637323651321742 ITSN1 1 GO:0060134 prepulse inhibition 1/803 12/18722 0.409160250276954 0.637323651321742 PTEN 1 GO:0060601 lateral sprouting from an epithelium 1/803 12/18722 0.409160250276954 0.637323651321742 BMP4 1 GO:0070202 regulation of establishment of protein localization to chromosome 1/803 12/18722 0.409160250276954 0.637323651321742 TERF1 1 GO:0070857 regulation of bile acid biosynthetic process 1/803 12/18722 0.409160250276954 0.637323651321742 CES1 1 GO:0071107 response to parathyroid hormone 1/803 12/18722 0.409160250276954 0.637323651321742 GJA1 1 GO:0071472 cellular response to salt stress 1/803 12/18722 0.409160250276954 0.637323651321742 ZFP36L1 1 GO:0072376 protein activation cascade 1/803 12/18722 0.409160250276954 0.637323651321742 FBLN1 1 GO:0072520 seminiferous tubule development 1/803 12/18722 0.409160250276954 0.637323651321742 ATRX 1 GO:0072584 caveolin-mediated endocytosis 1/803 12/18722 0.409160250276954 0.637323651321742 ITSN1 1 GO:0072711 cellular response to hydroxyurea 1/803 12/18722 0.409160250276954 0.637323651321742 ATRX 1 GO:0097152 mesenchymal cell apoptotic process 1/803 12/18722 0.409160250276954 0.637323651321742 HOXA13 1 GO:0098911 regulation of ventricular cardiac muscle cell action potential 1/803 12/18722 0.409160250276954 0.637323651321742 BIN1 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/803 12/18722 0.409160250276954 0.637323651321742 FARP1 1 GO:0099151 regulation of postsynaptic density assembly 1/803 12/18722 0.409160250276954 0.637323651321742 PTPRD 1 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/803 12/18722 0.409160250276954 0.637323651321742 CD36 1 GO:0150065 regulation of deacetylase activity 1/803 12/18722 0.409160250276954 0.637323651321742 CAMK2D 1 GO:1901503 ether biosynthetic process 1/803 12/18722 0.409160250276954 0.637323651321742 LPCAT2 1 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 1/803 12/18722 0.409160250276954 0.637323651321742 HSPA2 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/803 12/18722 0.409160250276954 0.637323651321742 PLXNB2 1 GO:1902563 regulation of neutrophil activation 1/803 12/18722 0.409160250276954 0.637323651321742 PLA2G2A 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/803 12/18722 0.409160250276954 0.637323651321742 BMP4 1 GO:1904748 regulation of apoptotic process involved in development 1/803 12/18722 0.409160250276954 0.637323651321742 TNFRSF1A 1 GO:1905205 positive regulation of connective tissue replacement 1/803 12/18722 0.409160250276954 0.637323651321742 ROCK2 1 GO:1905214 regulation of RNA binding 1/803 12/18722 0.409160250276954 0.637323651321742 NUCKS1 1 GO:1905709 negative regulation of membrane permeability 1/803 12/18722 0.409160250276954 0.637323651321742 HEG1 1 GO:2000035 regulation of stem cell division 1/803 12/18722 0.409160250276954 0.637323651321742 MLLT3 1 GO:2000105 positive regulation of DNA-dependent DNA replication 1/803 12/18722 0.409160250276954 0.637323651321742 ATRX 1 GO:2000303 regulation of ceramide biosynthetic process 1/803 12/18722 0.409160250276954 0.637323651321742 PRKAA1 1 GO:2000344 positive regulation of acrosome reaction 1/803 12/18722 0.409160250276954 0.637323651321742 PLCB1 1 GO:2000508 regulation of dendritic cell chemotaxis 1/803 12/18722 0.409160250276954 0.637323651321742 GAS6 1 GO:2000628 regulation of miRNA metabolic process 1/803 12/18722 0.409160250276954 0.637323651321742 KCNQ1OT1 1 GO:0010524 positive regulation of calcium ion transport into cytosol 3/803 54/18722 0.410147961681567 0.638263962841539 THY1/PKD2/ABL1 3 GO:0014888 striated muscle adaptation 3/803 54/18722 0.410147961681567 0.638263962841539 IGFBP5/GATA6/GSN 3 GO:0086002 cardiac muscle cell action potential involved in contraction 3/803 54/18722 0.410147961681567 0.638263962841539 GJA1/BIN1/FLNA 3 GO:0007052 mitotic spindle organization 6/803 120/18722 0.410396859774257 0.638452025845381 FLNA/PKD1/GNAI1/MAP9/SBDS/CLTC 6 GO:0009150 purine ribonucleotide metabolic process 17/803 368/18722 0.411840133278167 0.640278390435449 ENPP1/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 17 GO:0001937 negative regulation of endothelial cell proliferation 4/803 76/18722 0.412084507602759 0.640278390435449 SPARC/THBS1/APOE/GJA1 4 GO:0006305 DNA alkylation 4/803 76/18722 0.412084507602759 0.640278390435449 MAEL/KMT2A/ATRX/KMT2E 4 GO:0006306 DNA methylation 4/803 76/18722 0.412084507602759 0.640278390435449 MAEL/KMT2A/ATRX/KMT2E 4 GO:1903362 regulation of cellular protein catabolic process 12/803 255/18722 0.412952684874841 0.640910659082924 APOE/PRICKLE1/LAPTM4B/CD81/PTEN/PKD1/LRP1/CLU/NUPR1/DAB2/MSN/HECTD1 12 GO:0032635 interleukin-6 production 8/803 165/18722 0.413005605221306 0.640910659082924 HGF/SPON2/GAS6/CD36/HLA-B/TWIST1/CAPN2/STAT3 8 GO:0032675 regulation of interleukin-6 production 8/803 165/18722 0.413005605221306 0.640910659082924 HGF/SPON2/GAS6/CD36/HLA-B/TWIST1/CAPN2/STAT3 8 GO:0050796 regulation of insulin secretion 8/803 165/18722 0.413005605221306 0.640910659082924 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/CLOCK 8 GO:0007623 circadian rhythm 10/803 210/18722 0.413491599714418 0.641465188604882 PTGDS/PTEN/ROCK2/KMT2A/SETX/PRKAA1/ZFHX3/CLOCK/USP9X/HEBP1 10 GO:0038061 NIK/NF-kappaB signaling 7/803 143/18722 0.415614626922683 0.642648709583664 UACA/NFAT5/AGO3/LITAF/COPS8/ACTN4/TSPAN6 7 GO:0002335 mature B cell differentiation 2/803 33/18722 0.416703425207378 0.642648709583664 LGALS1/NOTCH2 2 GO:0006654 phosphatidic acid biosynthetic process 2/803 33/18722 0.416703425207378 0.642648709583664 AGPAT2/LPIN1 2 GO:0010737 protein kinase A signaling 2/803 33/18722 0.416703425207378 0.642648709583664 AKAP12/PJA2 2 GO:0019362 pyridine nucleotide metabolic process 2/803 33/18722 0.416703425207378 0.642648709583664 NNMT/NADK2 2 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 2/803 33/18722 0.416703425207378 0.642648709583664 VTN/EMILIN1 2 GO:0031116 positive regulation of microtubule polymerization 2/803 33/18722 0.416703425207378 0.642648709583664 MAP1B/NIN 2 GO:0045920 negative regulation of exocytosis 2/803 33/18722 0.416703425207378 0.642648709583664 STXBP6/HLA-F 2 GO:0046496 nicotinamide nucleotide metabolic process 2/803 33/18722 0.416703425207378 0.642648709583664 NNMT/NADK2 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/803 33/18722 0.416703425207378 0.642648709583664 THRA/MED13 2 GO:0071763 nuclear membrane organization 2/803 33/18722 0.416703425207378 0.642648709583664 PRKCA/LPIN1 2 GO:0099084 postsynaptic specialization organization 2/803 33/18722 0.416703425207378 0.642648709583664 PTPRD/PTEN 2 GO:0099174 regulation of presynapse organization 2/803 33/18722 0.416703425207378 0.642648709583664 PTPRD/FARP1 2 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 2/803 33/18722 0.416703425207378 0.642648709583664 SLIT2/YAP1 2 GO:1901380 negative regulation of potassium ion transmembrane transport 2/803 33/18722 0.416703425207378 0.642648709583664 BIN1/PTEN 2 GO:1903146 regulation of autophagy of mitochondrion 2/803 33/18722 0.416703425207378 0.642648709583664 TSPO/BNIP3L 2 GO:1903715 regulation of aerobic respiration 2/803 33/18722 0.416703425207378 0.642648709583664 COX7A1/NUPR1 2 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 2/803 33/18722 0.416703425207378 0.642648709583664 CAMK2N1/PTEN 2 GO:1905606 regulation of presynapse assembly 2/803 33/18722 0.416703425207378 0.642648709583664 PTPRD/FARP1 2 GO:0042752 regulation of circadian rhythm 6/803 121/18722 0.418092771504909 0.644591532547832 PTGDS/ROCK2/PRKAA1/ZFHX3/CLOCK/USP9X 6 GO:0034976 response to endoplasmic reticulum stress 12/803 256/18722 0.418221742437271 0.644591532547832 SRPX/CREB3L1/THBS1/MAN1A1/CLU/PIK3R1/NUPR1/SERINC3/HSP90B1/AMFR/MBTPS1/CANX 12 GO:0002444 myeloid leukocyte mediated immunity 5/803 99/18722 0.420276237674152 0.645562266679416 PTGDS/SPON2/FER/KMT2E/SERPINB9 5 GO:0031341 regulation of cell killing 5/803 99/18722 0.420276237674152 0.645562266679416 HLA-B/HLA-A/B2M/HLA-F/SERPINB9 5 GO:0010676 positive regulation of cellular carbohydrate metabolic process 3/803 55/18722 0.421720200457272 0.645562266679416 NNMT/IGF2/IRS1 3 GO:0031113 regulation of microtubule polymerization 3/803 55/18722 0.421720200457272 0.645562266679416 MAP1B/NIN/ABL1 3 GO:0048016 inositol phosphate-mediated signaling 3/803 55/18722 0.421720200457272 0.645562266679416 LMCD1/NFAT5/PRNP 3 GO:0140056 organelle localization by membrane tethering 4/803 77/18722 0.421801632152372 0.645562266679416 STX2/PDZD8/CEP290/ESYT2 4 GO:1901983 regulation of protein acetylation 4/803 77/18722 0.421801632152372 0.645562266679416 TWIST1/KMT2A/TAOK1/PRKAA1 4 GO:0010821 regulation of mitochondrion organization 7/803 144/18722 0.422669723812002 0.645562266679416 DCN/HGF/CLU/TSPO/PLAUR/PID1/BNIP3L 7 GO:0031644 regulation of nervous system process 7/803 144/18722 0.422669723812002 0.645562266679416 HGF/SPX/EDNRB/TMEM98/PTEN/ROCK2/LPIN1 7 GO:0000280 nuclear division 20/803 439/18722 0.423215582283088 0.645562266679416 PDE3A/PDGFRB/HOXA13/MAEL/BMP4/FLNA/IGF2/CCDC8/HSPA2/PLCB1/EPS8/CDC25B/PRKAR1A/MAP9/PDS5B/ATRX/EML4/P3H4/TERF1/ATM 20 GO:0030258 lipid modification 10/803 212/18722 0.425108066526244 0.645562266679416 APOD/PLPP1/APOE/BDH2/PLPP3/IRS1/PTEN/PDK4/TWIST1/PRKAA1 10 GO:0015849 organic acid transport 14/803 303/18722 0.426430097138607 0.645562266679416 PLA2G2A/SLC16A10/SPX/CD36/THBS1/APOE/GJA1/SLC16A7/SERINC3/ITGB1/SLC38A2/PLA2R1/PRKAA1/SERINC5 14 GO:0051222 positive regulation of protein transport 14/803 303/18722 0.426430097138607 0.645562266679416 GAS6/CAMK2N1/GJA1/FLNA/CD81/LRP1/PIK3R1/PRNP/NPEPPS/SAR1A/STOM/PRKAA1/MYO1C/CEP290 14 GO:0016311 dephosphorylation 19/803 417/18722 0.426605881933197 0.645562266679416 PDGFRB/PTPRD/PLPP1/ITGA1/PLPP3/MFHAS1/PTEN/PPM1K/PTPRK/ROCK2/CDC25B/PTPRG/DLC1/PTPRA/LPIN1/HSP90B1/PPP2R5E/PTP4A2/TNS3 19 GO:0044728 DNA methylation or demethylation 5/803 100/18722 0.428788764745449 0.645562266679416 MAEL/KMT2A/ATRX/KMT2E/USP9X 5 GO:0061640 cytoskeleton-dependent cytokinesis 5/803 100/18722 0.428788764745449 0.645562266679416 SPTBN1/SON/ROCK2/MAP9/PLEC 5 GO:0046390 ribose phosphate biosynthetic process 9/803 190/18722 0.42878989522588 0.645562266679416 GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/PID1/STAT3/PANK3/PAPSS1 9 GO:0061351 neural precursor cell proliferation 7/803 145/18722 0.42971613585912 0.645562266679416 WNT2/SOX5/FLNA/MDK/PLXNB2/FRS2/FOXO3 7 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 4/803 78/18722 0.43147940168906 0.645562266679416 F3/ROBO1/EGLN3/DLC1 4 GO:0008306 associative learning 4/803 78/18722 0.43147940168906 0.645562266679416 ADCY3/MEIS2/ITGB1/NPTN 4 GO:0009064 glutamine family amino acid metabolic process 4/803 78/18722 0.43147940168906 0.645562266679416 GLS/DDAH2/GCLM/OAT 4 GO:0043537 negative regulation of blood vessel endothelial cell migration 4/803 78/18722 0.43147940168906 0.645562266679416 THBS1/APOE/SPRED1/KLF4 4 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 4/803 78/18722 0.43147940168906 0.645562266679416 THBS1/SPRED1/KLF4/ABL1 4 GO:0090559 regulation of membrane permeability 4/803 78/18722 0.43147940168906 0.645562266679416 HEG1/LAPTM4B/STAT3/BNIP3L 4 GO:0007095 mitotic G2 DNA damage checkpoint signaling 2/803 34/18722 0.431647230720897 0.645562266679416 TAOK1/ATM 2 GO:0010922 positive regulation of phosphatase activity 2/803 34/18722 0.431647230720897 0.645562266679416 PDGFRB/ITGA1 2 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/803 34/18722 0.431647230720897 0.645562266679416 CAMK2D/SLC8A1 2 GO:0032212 positive regulation of telomere maintenance via telomerase 2/803 34/18722 0.431647230720897 0.645562266679416 NEK7/ATM 2 GO:0032743 positive regulation of interleukin-2 production 2/803 34/18722 0.431647230720897 0.645562266679416 SPTBN1/ABL1 2 GO:0035308 negative regulation of protein dephosphorylation 2/803 34/18722 0.431647230720897 0.645562266679416 MFHAS1/ROCK2 2 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2/803 34/18722 0.431647230720897 0.645562266679416 PUM2/TSPAN6 2 GO:0048741 skeletal muscle fiber development 2/803 34/18722 0.431647230720897 0.645562266679416 PLEC/SKI 2 GO:0050869 negative regulation of B cell activation 2/803 34/18722 0.431647230720897 0.645562266679416 ATM/NDFIP1 2 GO:0051973 positive regulation of telomerase activity 2/803 34/18722 0.431647230720897 0.645562266679416 KLF4/NEK7 2 GO:0070050 neuron cellular homeostasis 2/803 34/18722 0.431647230720897 0.645562266679416 TAOK1/PRKAA1 2 GO:0086019 cell-cell signaling involved in cardiac conduction 2/803 34/18722 0.431647230720897 0.645562266679416 GJA1/FLNA 2 GO:0098751 bone cell development 2/803 34/18722 0.431647230720897 0.645562266679416 NOTCH2/FBN1 2 GO:2000780 negative regulation of double-strand break repair 2/803 34/18722 0.431647230720897 0.645562266679416 TWIST1/RNF169 2 GO:0030072 peptide hormone secretion 11/803 236/18722 0.432627804048932 0.645562266679416 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 11 GO:0090068 positive regulation of cell cycle process 11/803 236/18722 0.432627804048932 0.645562266679416 CCND2/PDGFRB/HOXA13/ADAMTS1/IGF2/HSPA2/ROCK2/PLCB1/CDC25B/ATRX/KMT2E 11 GO:0002706 regulation of lymphocyte mediated immunity 8/803 168/18722 0.432661361501772 0.645562266679416 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F/SERPINB9/NDFIP1 8 GO:0002449 lymphocyte mediated immunity 16/803 350/18722 0.433090667995977 0.645562266679416 C7/C1R/C1S/IL1R1/C2/HLA-B/SERPING1/HLA-A/CD81/B2M/CLU/HLA-F/JAG1/SERPINB9/NDFIP1/BTN3A2 16 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/803 56/18722 0.43321446837766 0.645562266679416 TNRC6C/ZFP36L2/ZFP36L1 3 GO:0051784 negative regulation of nuclear division 3/803 56/18722 0.43321446837766 0.645562266679416 BMP4/PRKAR1A/ATM 3 GO:0071482 cellular response to light stimulus 6/803 123/18722 0.433445163883705 0.645562266679416 MMP2/MFAP4/TIMP1/PTPRK/PIK3R1/USP47 6 GO:0001682 tRNA 5'-leader removal 1/803 13/18722 0.434518043918195 0.645562266679416 RPP25 1 GO:0001768 establishment of T cell polarity 1/803 13/18722 0.434518043918195 0.645562266679416 GSN 1 GO:0001833 inner cell mass cell proliferation 1/803 13/18722 0.434518043918195 0.645562266679416 SBDS 1 GO:0002087 regulation of respiratory gaseous exchange by nervous system process 1/803 13/18722 0.434518043918195 0.645562266679416 GLS 1 GO:0002430 complement receptor mediated signaling pathway 1/803 13/18722 0.434518043918195 0.645562266679416 CMKLR1 1 GO:0002638 negative regulation of immunoglobulin production 1/803 13/18722 0.434518043918195 0.645562266679416 NDFIP1 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/803 13/18722 0.434518043918195 0.645562266679416 BMP4 1 GO:0007183 SMAD protein complex assembly 1/803 13/18722 0.434518043918195 0.645562266679416 LDLRAD4 1 GO:0007494 midgut development 1/803 13/18722 0.434518043918195 0.645562266679416 EDNRB 1 GO:0007512 adult heart development 1/803 13/18722 0.434518043918195 0.645562266679416 HAND2 1 GO:0007567 parturition 1/803 13/18722 0.434518043918195 0.645562266679416 PTGFR 1 GO:0008298 intracellular mRNA localization 1/803 13/18722 0.434518043918195 0.645562266679416 ZFP36L1 1 GO:0009143 nucleoside triphosphate catabolic process 1/803 13/18722 0.434518043918195 0.645562266679416 ENPP1 1 GO:0009437 carnitine metabolic process 1/803 13/18722 0.434518043918195 0.645562266679416 ALDH9A1 1 GO:0009650 UV protection 1/803 13/18722 0.434518043918195 0.645562266679416 MFAP4 1 GO:0010635 regulation of mitochondrial fusion 1/803 13/18722 0.434518043918195 0.645562266679416 PID1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/803 13/18722 0.434518043918195 0.645562266679416 ABCA5 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/803 13/18722 0.434518043918195 0.645562266679416 BNIP3L 1 GO:0010958 regulation of amino acid import across plasma membrane 1/803 13/18722 0.434518043918195 0.645562266679416 ITGB1 1 GO:0014029 neural crest formation 1/803 13/18722 0.434518043918195 0.645562266679416 LRP6 1 GO:0015791 polyol transport 1/803 13/18722 0.434518043918195 0.645562266679416 SLC5A3 1 GO:0015801 aromatic amino acid transport 1/803 13/18722 0.434518043918195 0.645562266679416 SLC16A10 1 GO:0016024 CDP-diacylglycerol biosynthetic process 1/803 13/18722 0.434518043918195 0.645562266679416 AGPAT2 1 GO:0021859 pyramidal neuron differentiation 1/803 13/18722 0.434518043918195 0.645562266679416 ZMIZ1 1 GO:0021984 adenohypophysis development 1/803 13/18722 0.434518043918195 0.645562266679416 PITX2 1 GO:0030497 fatty acid elongation 1/803 13/18722 0.434518043918195 0.645562266679416 ELOVL2 1 GO:0030836 positive regulation of actin filament depolymerization 1/803 13/18722 0.434518043918195 0.645562266679416 CFL2 1 GO:0031053 primary miRNA processing 1/803 13/18722 0.434518043918195 0.645562266679416 STAT3 1 GO:0032352 positive regulation of hormone metabolic process 1/803 13/18722 0.434518043918195 0.645562266679416 RDH10 1 GO:0032530 regulation of microvillus organization 1/803 13/18722 0.434518043918195 0.645562266679416 FSCN1 1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1/803 13/18722 0.434518043918195 0.645562266679416 YAP1 1 GO:0033262 regulation of nuclear cell cycle DNA replication 1/803 13/18722 0.434518043918195 0.645562266679416 ATRX 1 GO:0033700 phospholipid efflux 1/803 13/18722 0.434518043918195 0.645562266679416 APOE 1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 1/803 13/18722 0.434518043918195 0.645562266679416 MFHAS1 1 GO:0035745 T-helper 2 cell cytokine production 1/803 13/18722 0.434518043918195 0.645562266679416 CD81 1 GO:0042538 hyperosmotic salinity response 1/803 13/18722 0.434518043918195 0.645562266679416 CLDN1 1 GO:0042541 hemoglobin biosynthetic process 1/803 13/18722 0.434518043918195 0.645562266679416 KLF4 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/803 13/18722 0.434518043918195 0.645562266679416 ELOVL2 1 GO:0043201 response to leucine 1/803 13/18722 0.434518043918195 0.645562266679416 SESN3 1 GO:0043970 histone H3-K9 acetylation 1/803 13/18722 0.434518043918195 0.645562266679416 KMT2A 1 GO:0046642 negative regulation of alpha-beta T cell proliferation 1/803 13/18722 0.434518043918195 0.645562266679416 TWSG1 1 GO:0048012 hepatocyte growth factor receptor signaling pathway 1/803 13/18722 0.434518043918195 0.645562266679416 HGF 1 GO:0048207 vesicle targeting, rough ER to cis-Golgi 1/803 13/18722 0.434518043918195 0.645562266679416 SAR1A 1 GO:0048208 COPII vesicle coating 1/803 13/18722 0.434518043918195 0.645562266679416 SAR1A 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/803 13/18722 0.434518043918195 0.645562266679416 NDFIP1 1 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 1/803 13/18722 0.434518043918195 0.645562266679416 PKD2 1 GO:0051709 regulation of killing of cells of other organism 1/803 13/18722 0.434518043918195 0.645562266679416 SERPINB9 1 GO:0055062 phosphate ion homeostasis 1/803 13/18722 0.434518043918195 0.645562266679416 ENPP1 1 GO:0060100 positive regulation of phagocytosis, engulfment 1/803 13/18722 0.434518043918195 0.645562266679416 CD36 1 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/803 13/18722 0.434518043918195 0.645562266679416 TNRC6C 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/803 13/18722 0.434518043918195 0.645562266679416 BACH1 1 GO:0061469 regulation of type B pancreatic cell proliferation 1/803 13/18722 0.434518043918195 0.645562266679416 NUPR1 1 GO:0070486 leukocyte aggregation 1/803 13/18722 0.434518043918195 0.645562266679416 MSN 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/803 13/18722 0.434518043918195 0.645562266679416 NIN 1 GO:0072506 trivalent inorganic anion homeostasis 1/803 13/18722 0.434518043918195 0.645562266679416 ENPP1 1 GO:0072578 neurotransmitter-gated ion channel clustering 1/803 13/18722 0.434518043918195 0.645562266679416 APOE 1 GO:0072710 response to hydroxyurea 1/803 13/18722 0.434518043918195 0.645562266679416 ATRX 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/803 13/18722 0.434518043918195 0.645562266679416 PRKAA1 1 GO:0090158 endoplasmic reticulum membrane organization 1/803 13/18722 0.434518043918195 0.645562266679416 RTN4 1 GO:0098814 spontaneous synaptic transmission 1/803 13/18722 0.434518043918195 0.645562266679416 ITGB1 1 GO:0098840 protein transport along microtubule 1/803 13/18722 0.434518043918195 0.645562266679416 HSPB1 1 GO:0099118 microtubule-based protein transport 1/803 13/18722 0.434518043918195 0.645562266679416 HSPB1 1 GO:0099150 regulation of postsynaptic specialization assembly 1/803 13/18722 0.434518043918195 0.645562266679416 PTPRD 1 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/803 13/18722 0.434518043918195 0.645562266679416 PRKCA 1 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 1/803 13/18722 0.434518043918195 0.645562266679416 PIK3R1 1 GO:1900115 extracellular regulation of signal transduction 1/803 13/18722 0.434518043918195 0.645562266679416 FBN1 1 GO:1900116 extracellular negative regulation of signal transduction 1/803 13/18722 0.434518043918195 0.645562266679416 FBN1 1 GO:1900121 negative regulation of receptor binding 1/803 13/18722 0.434518043918195 0.645562266679416 B2M 1 GO:1903789 regulation of amino acid transmembrane transport 1/803 13/18722 0.434518043918195 0.645562266679416 ITGB1 1 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/803 13/18722 0.434518043918195 0.645562266679416 KLF4 1 GO:1905038 regulation of membrane lipid metabolic process 1/803 13/18722 0.434518043918195 0.645562266679416 PRKAA1 1 GO:1905155 positive regulation of membrane invagination 1/803 13/18722 0.434518043918195 0.645562266679416 CD36 1 GO:1905203 regulation of connective tissue replacement 1/803 13/18722 0.434518043918195 0.645562266679416 ROCK2 1 GO:1905939 regulation of gonad development 1/803 13/18722 0.434518043918195 0.645562266679416 NUPR1 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/803 13/18722 0.434518043918195 0.645562266679416 CD81 1 GO:2001023 regulation of response to drug 1/803 13/18722 0.434518043918195 0.645562266679416 NCOA1 1 GO:0006164 purine nucleotide biosynthetic process 9/803 191/18722 0.434929870427458 0.645981630608075 GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/PID1/STAT3/PANK3/PAPSS1 9 GO:0072330 monocarboxylic acid biosynthetic process 10/803 214/18722 0.436715112144729 0.648440008681841 PTGDS/RBP1/ELOVL2/CES1/RDH10/PDK4/LPGAT1/OSBPL1A/PRKAA1/FADS3 10 GO:0050867 positive regulation of cell activation 19/803 420/18722 0.439053929875418 0.65171863481954 IGFBP2/VCAM1/THY1/PDGFRB/GAS6/THBS1/IL6ST/IGF2/LGALS1/HLA-A/CD81/MDK/AXL/DPP4/B2M/TGFBR2/MAP3K8/HLA-F/ZMIZ1 19 GO:0007601 visual perception 10/803 215/18722 0.442512059138092 0.656656287756704 LUM/COL1A1/LAMC3/COL11A1/TGFBI/RDH10/LAMB2/TIMP3/EPAS1/OAT 10 GO:1903531 negative regulation of secretion by cell 7/803 147/18722 0.443774481065842 0.658333699075955 STXBP6/APOE/GJA1/IRS1/TNFRSF1A/HLA-F/MAP4K4 7 GO:0010883 regulation of lipid storage 3/803 57/18722 0.44462357532719 0.658809256042012 CD36/CES1/MEST 3 GO:0050891 multicellular organismal water homeostasis 3/803 57/18722 0.44462357532719 0.658809256042012 CLDN1/EXT1/PLEC 3 GO:0051155 positive regulation of striated muscle cell differentiation 3/803 57/18722 0.44462357532719 0.658809256042012 BMP4/EFNB2/PIEZO1 3 GO:0060042 retina morphogenesis in camera-type eye 3/803 57/18722 0.44462357532719 0.658809256042012 THY1/PROM1/HIPK1 3 GO:0035710 CD4-positive, alpha-beta T cell activation 5/803 102/18722 0.445734501956759 0.659457891548131 TMEM98/TWSG1/CD81/TGFBR2/STAT3 5 GO:0006739 NADP metabolic process 2/803 35/18722 0.446383951860197 0.659457891548131 H6PD/NADK2 2 GO:0032205 negative regulation of telomere maintenance 2/803 35/18722 0.446383951860197 0.659457891548131 TERF1/ATM 2 GO:0034331 cell junction maintenance 2/803 35/18722 0.446383951860197 0.659457891548131 CLDN1/TJP1 2 GO:0043243 positive regulation of protein-containing complex disassembly 2/803 35/18722 0.446383951860197 0.659457891548131 CFL2/SETX 2 GO:0045880 positive regulation of smoothened signaling pathway 2/803 35/18722 0.446383951860197 0.659457891548131 GPC3/TXNDC15 2 GO:0097421 liver regeneration 2/803 35/18722 0.446383951860197 0.659457891548131 CLDN1/SULF2 2 GO:0098810 neurotransmitter reuptake 2/803 35/18722 0.446383951860197 0.659457891548131 SLC22A3/ITGB1 2 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 2/803 35/18722 0.446383951860197 0.659457891548131 CAMK2D/SLC8A1 2 GO:1905898 positive regulation of response to endoplasmic reticulum stress 2/803 35/18722 0.446383951860197 0.659457891548131 PIK3R1/SERINC3 2 GO:0018205 peptidyl-lysine modification 17/803 376/18722 0.446973945831197 0.660133914074155 NNMT/LOXL1/PLOD2/FKBP10/PIAS2/KAT6B/TWIST1/KMT2A/ASH1L/ATRX/PRKAA1/ZMIZ1/P3H4/KMT2E/RTF1/CLOCK/NCOA1 17 GO:0032204 regulation of telomere maintenance 4/803 80/18722 0.450697589427814 0.664204724965675 ATRX/TERF1/NEK7/ATM 4 GO:1901264 carbohydrate derivative transport 4/803 80/18722 0.450697589427814 0.664204724965675 GJA1/PLTP/VLDLR/NPC2 4 GO:0006909 phagocytosis 14/803 308/18722 0.450715700105087 0.664204724965675 SRPX/SPON2/GAS6/CD36/THBS1/MFGE8/C2/PTEN/LRP1/AXL/ITGB1/CNN2/ABL1/GSN 14 GO:0002285 lymphocyte activation involved in immune response 9/803 194/18722 0.453307201173946 0.664204724965675 TMEM98/LGALS1/CD81/MDK/NOTCH2/ABL1/HLA-F/STAT3/NDFIP1 9 GO:0009135 purine nucleoside diphosphate metabolic process 5/803 103/18722 0.454160947713467 0.664204724965675 CASK/NUPR1/MAGI3/STAT3/PRKAA1 5 GO:0009179 purine ribonucleoside diphosphate metabolic process 5/803 103/18722 0.454160947713467 0.664204724965675 CASK/NUPR1/MAGI3/STAT3/PRKAA1 5 GO:0019395 fatty acid oxidation 5/803 103/18722 0.454160947713467 0.664204724965675 BDH2/IRS1/PDK4/TWIST1/PRKAA1 5 GO:0007405 neuroblast proliferation 3/803 58/18722 0.455940771491369 0.664204724965675 SOX5/PLXNB2/FRS2 3 GO:0010574 regulation of vascular endothelial growth factor production 3/803 58/18722 0.455940771491369 0.664204724965675 GATA4/IL6ST/SULF2 3 GO:0045604 regulation of epidermal cell differentiation 3/803 58/18722 0.455940771491369 0.664204724965675 BMP4/ROCK2/ZFP36L1 3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 3/803 58/18722 0.455940771491369 0.664204724965675 NUPR1/SERINC3/SKIL 3 GO:0009411 response to UV 7/803 149/18722 0.457773212141976 0.664204724965675 MMP2/MFAP4/TIMP1/PTPRK/PIK3R1/PRKAA1/USP47 7 GO:0000212 meiotic spindle organization 1/803 14/18722 0.458788823261489 0.664204724965675 ATRX 1 GO:0001767 establishment of lymphocyte polarity 1/803 14/18722 0.458788823261489 0.664204724965675 GSN 1 GO:0001921 positive regulation of receptor recycling 1/803 14/18722 0.458788823261489 0.664204724965675 ECE1 1 GO:0002829 negative regulation of type 2 immune response 1/803 14/18722 0.458788823261489 0.664204724965675 NDFIP1 1 GO:0003214 cardiac left ventricle morphogenesis 1/803 14/18722 0.458788823261489 0.664204724965675 TGFBR2 1 GO:0006596 polyamine biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 NNMT 1 GO:0006999 nuclear pore organization 1/803 14/18722 0.458788823261489 0.664204724965675 RTN4 1 GO:0007100 mitotic centrosome separation 1/803 14/18722 0.458788823261489 0.664204724965675 MAP9 1 GO:0010872 regulation of cholesterol esterification 1/803 14/18722 0.458788823261489 0.664204724965675 APOE 1 GO:0018158 protein oxidation 1/803 14/18722 0.458788823261489 0.664204724965675 LOXL1 1 GO:0022038 corpus callosum development 1/803 14/18722 0.458788823261489 0.664204724965675 NIN 1 GO:0030049 muscle filament sliding 1/803 14/18722 0.458788823261489 0.664204724965675 TPM1 1 GO:0030213 hyaluronan biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 CLTC 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/803 14/18722 0.458788823261489 0.664204724965675 EMILIN1 1 GO:0031054 pre-miRNA processing 1/803 14/18722 0.458788823261489 0.664204724965675 AGO3 1 GO:0031650 regulation of heat generation 1/803 14/18722 0.458788823261489 0.664204724965675 EDNRB 1 GO:0032966 negative regulation of collagen biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 EMILIN1 1 GO:0034616 response to laminar fluid shear stress 1/803 14/18722 0.458788823261489 0.664204724965675 KLF4 1 GO:0035437 maintenance of protein localization in endoplasmic reticulum 1/803 14/18722 0.458788823261489 0.664204724965675 GJA1 1 GO:0035563 positive regulation of chromatin binding 1/803 14/18722 0.458788823261489 0.664204724965675 ZNF618 1 GO:0035672 oligopeptide transmembrane transport 1/803 14/18722 0.458788823261489 0.664204724965675 GJA1 1 GO:0035810 positive regulation of urine volume 1/803 14/18722 0.458788823261489 0.664204724965675 EDNRB 1 GO:0035815 positive regulation of renal sodium excretion 1/803 14/18722 0.458788823261489 0.664204724965675 EDNRB 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/803 14/18722 0.458788823261489 0.664204724965675 LPCAT2 1 GO:0038166 angiotensin-activated signaling pathway 1/803 14/18722 0.458788823261489 0.664204724965675 ROCK2 1 GO:0038183 bile acid signaling pathway 1/803 14/18722 0.458788823261489 0.664204724965675 PRKAA1 1 GO:0042363 fat-soluble vitamin catabolic process 1/803 14/18722 0.458788823261489 0.664204724965675 CRABP1 1 GO:0043455 regulation of secondary metabolic process 1/803 14/18722 0.458788823261489 0.664204724965675 ZEB2 1 GO:0043650 dicarboxylic acid biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 GLS 1 GO:0043922 negative regulation by host of viral transcription 1/803 14/18722 0.458788823261489 0.664204724965675 NUCKS1 1 GO:0044154 histone H3-K14 acetylation 1/803 14/18722 0.458788823261489 0.664204724965675 KMT2A 1 GO:0045837 negative regulation of membrane potential 1/803 14/18722 0.458788823261489 0.664204724965675 BNIP3L 1 GO:0046341 CDP-diacylglycerol metabolic process 1/803 14/18722 0.458788823261489 0.664204724965675 AGPAT2 1 GO:0048021 regulation of melanin biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 ZEB2 1 GO:0048291 isotype switching to IgG isotypes 1/803 14/18722 0.458788823261489 0.664204724965675 NDFIP1 1 GO:0048368 lateral mesoderm development 1/803 14/18722 0.458788823261489 0.664204724965675 YAP1 1 GO:0048875 chemical homeostasis within a tissue 1/803 14/18722 0.458788823261489 0.664204724965675 EPAS1 1 GO:0050872 white fat cell differentiation 1/803 14/18722 0.458788823261489 0.664204724965675 PDGFRA 1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 1/803 14/18722 0.458788823261489 0.664204724965675 TMEM120A 1 GO:0051645 Golgi localization 1/803 14/18722 0.458788823261489 0.664204724965675 ARHGAP21 1 GO:0055057 neuroblast division 1/803 14/18722 0.458788823261489 0.664204724965675 SOX5 1 GO:0061043 regulation of vascular wound healing 1/803 14/18722 0.458788823261489 0.664204724965675 SMOC2 1 GO:0061709 reticulophagy 1/803 14/18722 0.458788823261489 0.664204724965675 RB1CC1 1 GO:0071415 cellular response to purine-containing compound 1/803 14/18722 0.458788823261489 0.664204724965675 SLC8A1 1 GO:0072531 pyrimidine-containing compound transmembrane transport 1/803 14/18722 0.458788823261489 0.664204724965675 SLC19A3 1 GO:0072540 T-helper 17 cell lineage commitment 1/803 14/18722 0.458788823261489 0.664204724965675 STAT3 1 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 1/803 14/18722 0.458788823261489 0.664204724965675 AKAP13 1 GO:0090128 regulation of synapse maturation 1/803 14/18722 0.458788823261489 0.664204724965675 CLSTN1 1 GO:0097091 synaptic vesicle clustering 1/803 14/18722 0.458788823261489 0.664204724965675 PTEN 1 GO:0099188 postsynaptic cytoskeleton organization 1/803 14/18722 0.458788823261489 0.664204724965675 FARP1 1 GO:1900037 regulation of cellular response to hypoxia 1/803 14/18722 0.458788823261489 0.664204724965675 ROCK2 1 GO:1900376 regulation of secondary metabolite biosynthetic process 1/803 14/18722 0.458788823261489 0.664204724965675 ZEB2 1 GO:1901077 regulation of relaxation of muscle 1/803 14/18722 0.458788823261489 0.664204724965675 CAMK2D 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/803 14/18722 0.458788823261489 0.664204724965675 BMP4 1 GO:1904814 regulation of protein localization to chromosome, telomeric region 1/803 14/18722 0.458788823261489 0.664204724965675 TERF1 1 GO:2001140 positive regulation of phospholipid transport 1/803 14/18722 0.458788823261489 0.664204724965675 APOE 1 GO:0000422 autophagy of mitochondrion 4/803 81/18722 0.460228856100989 0.665142288497188 CTSK/TSPO/BNIP3L/RB1CC1 4 GO:0061726 mitochondrion disassembly 4/803 81/18722 0.460228856100989 0.665142288497188 CTSK/TSPO/BNIP3L/RB1CC1 4 GO:2000243 positive regulation of reproductive process 4/803 81/18722 0.460228856100989 0.665142288497188 PDE3A/EDNRB/PLCB1/CDC25B 4 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2/803 36/18722 0.460903852137542 0.665142288497188 THBS1/B2M 2 GO:0006699 bile acid biosynthetic process 2/803 36/18722 0.460903852137542 0.665142288497188 CES1/OSBPL1A 2 GO:0014741 negative regulation of muscle hypertrophy 2/803 36/18722 0.460903852137542 0.665142288497188 IGFBP5/TNFRSF1A 2 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 2/803 36/18722 0.460903852137542 0.665142288497188 CAMK2N1/LRP1 2 GO:0042119 neutrophil activation 2/803 36/18722 0.460903852137542 0.665142288497188 PLA2G2A/KMT2E 2 GO:0045738 negative regulation of DNA repair 2/803 36/18722 0.460903852137542 0.665142288497188 TWIST1/RNF169 2 GO:0090322 regulation of superoxide metabolic process 2/803 36/18722 0.460903852137542 0.665142288497188 FBLN5/CD36 2 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 2/803 36/18722 0.460903852137542 0.665142288497188 NPEPPS/PRKAA1 2 GO:0032006 regulation of TOR signaling 5/803 104/18722 0.462552111107719 0.667134748621084 GAS6/SESN3/GPR137B/PRKAA1/ATM 5 GO:0045621 positive regulation of lymphocyte differentiation 5/803 104/18722 0.462552111107719 0.667134748621084 GAS6/MDK/AXL/TGFBR2/ZMIZ1 5 GO:0090276 regulation of peptide hormone secretion 9/803 196/18722 0.465509477723915 0.670808730367537 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 9 GO:0050953 sensory perception of light stimulus 10/803 219/18722 0.46562836017904 0.670808730367537 LUM/COL1A1/LAMC3/COL11A1/TGFBI/RDH10/LAMB2/TIMP3/EPAS1/OAT 10 GO:2001020 regulation of response to DNA damage stimulus 10/803 219/18722 0.46562836017904 0.670808730367537 SNAI2/CLU/TWIST1/SPRED1/ABL1/PLA2R1/SKIL/RNF169/ATM/USP47 10 GO:0002790 peptide secretion 11/803 242/18722 0.465637588407952 0.670808730367537 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 11 GO:0001836 release of cytochrome c from mitochondria 3/803 59/18722 0.467159736527247 0.672418720070685 HGF/CLU/PLAUR 3 GO:0033013 tetrapyrrole metabolic process 3/803 59/18722 0.467159736527247 0.672418720070685 BDH2/TSPO/PGRMC1 3 GO:0035306 positive regulation of dephosphorylation 3/803 59/18722 0.467159736527247 0.672418720070685 PDGFRB/ITGA1/DLC1 3 GO:0002312 B cell activation involved in immune response 4/803 82/18722 0.469702463120123 0.675312944106057 LGALS1/NOTCH2/ABL1/NDFIP1 4 GO:0009205 purine ribonucleoside triphosphate metabolic process 4/803 82/18722 0.469702463120123 0.675312944106057 RAB23/RHOQ/PID1/STAT3 4 GO:0016575 histone deacetylation 4/803 82/18722 0.469702463120123 0.675312944106057 CAMK2D/TBL1XR1/SKI/MIER1 4 GO:0071248 cellular response to metal ion 9/803 197/18722 0.471591808200307 0.675312944106057 CLDN1/SERPINF1/CAMK2D/B2M/PKD2/TSPO/PRNP/WNK1/PRKAA1 9 GO:0006261 DNA-dependent DNA replication 7/803 151/18722 0.47169653726077 0.675312944106057 REV3L/PURA/ATRX/FAM111A/RECQL/TERF1/NUCKS1 7 GO:0051052 regulation of DNA metabolic process 16/803 359/18722 0.473824474537882 0.675312944106057 HGF/PDGFRB/SMOC2/GJA1/TWIST1/KLF4/BMPR2/KMT2A/ATRX/RNF169/TERF1/NEK7/ATM/NUCKS1/NDFIP1/USP9X 16 GO:0003016 respiratory system process 2/803 37/18722 0.475198408784338 0.675312944106057 NDN/GLS 2 GO:0014904 myotube cell development 2/803 37/18722 0.475198408784338 0.675312944106057 PLEC/SKI 2 GO:0031112 positive regulation of microtubule polymerization or depolymerization 2/803 37/18722 0.475198408784338 0.675312944106057 MAP1B/NIN 2 GO:0033260 nuclear DNA replication 2/803 37/18722 0.475198408784338 0.675312944106057 ATRX/TERF1 2 GO:0034260 negative regulation of GTPase activity 2/803 37/18722 0.475198408784338 0.675312944106057 SPRY1/WNK1 2 GO:0042401 cellular biogenic amine biosynthetic process 2/803 37/18722 0.475198408784338 0.675312944106057 HAND2/NNMT 2 GO:0045616 regulation of keratinocyte differentiation 2/803 37/18722 0.475198408784338 0.675312944106057 ROCK2/ZFP36L1 2 GO:0051567 histone H3-K9 methylation 2/803 37/18722 0.475198408784338 0.675312944106057 ASH1L/ATRX 2 GO:0071985 multivesicular body sorting pathway 2/803 37/18722 0.475198408784338 0.675312944106057 LAPTM4B/SORT1 2 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 2/803 37/18722 0.475198408784338 0.675312944106057 NEK7/ATM 2 GO:0050954 sensory perception of mechanical stimulus 8/803 175/18722 0.478166031772097 0.675312944106057 COL1A1/COL11A1/SNAI2/SERPINE2/SCARB2/TMEM120A/CCDC50/NAV2 8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 3/803 60/18722 0.478274568269307 0.675312944106057 CELF2/DDX17/MBNL2 3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 3/803 60/18722 0.478274568269307 0.675312944106057 TIFA/PUM2/TSPAN6 3 GO:0031663 lipopolysaccharide-mediated signaling pathway 3/803 60/18722 0.478274568269307 0.675312944106057 CD36/PRKCA/MTDH 3 GO:0098754 detoxification 7/803 152/18722 0.478625174386349 0.675312944106057 FBLN5/CD36/APOE/SOD3/GPX7/GPX8/GSTM3 7 GO:0007127 meiosis I 6/803 129/18722 0.478999690804908 0.675312944106057 MAEL/HSPA2/CDC25B/P3H4/TERF1/ATM 6 GO:0009185 ribonucleoside diphosphate metabolic process 5/803 106/18722 0.479216228049624 0.675312944106057 CASK/NUPR1/MAGI3/STAT3/PRKAA1 5 GO:0035821 modulation of process of other organism 5/803 106/18722 0.479216228049624 0.675312944106057 APOE/IGF2R/STOM/SERPINB9/NUCKS1 5 GO:0071887 leukocyte apoptotic process 5/803 106/18722 0.479216228049624 0.675312944106057 KITLG/GAS6/BMP4/PTEN/AXL 5 GO:0001325 formation of extrachromosomal circular DNA 1/803 15/18722 0.482019129810614 0.675312944106057 TERF1 1 GO:0002468 dendritic cell antigen processing and presentation 1/803 15/18722 0.482019129810614 0.675312944106057 THBS1 1 GO:0002730 regulation of dendritic cell cytokine production 1/803 15/18722 0.482019129810614 0.675312944106057 BST2 1 GO:0006098 pentose-phosphate shunt 1/803 15/18722 0.482019129810614 0.675312944106057 H6PD 1 GO:0006825 copper ion transport 1/803 15/18722 0.482019129810614 0.675312944106057 STEAP4 1 GO:0006878 cellular copper ion homeostasis 1/803 15/18722 0.482019129810614 0.675312944106057 PRNP 1 GO:0010452 histone H3-K36 methylation 1/803 15/18722 0.482019129810614 0.675312944106057 ASH1L 1 GO:0010713 negative regulation of collagen metabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 EMILIN1 1 GO:0010752 regulation of cGMP-mediated signaling 1/803 15/18722 0.482019129810614 0.675312944106057 THBS1 1 GO:0010820 positive regulation of T cell chemotaxis 1/803 15/18722 0.482019129810614 0.675312944106057 WNK1 1 GO:0010940 positive regulation of necrotic cell death 1/803 15/18722 0.482019129810614 0.675312944106057 TSPO 1 GO:0014733 regulation of skeletal muscle adaptation 1/803 15/18722 0.482019129810614 0.675312944106057 IGFBP5 1 GO:0014744 positive regulation of muscle adaptation 1/803 15/18722 0.482019129810614 0.675312944106057 FOXO3 1 GO:0018410 C-terminal protein amino acid modification 1/803 15/18722 0.482019129810614 0.675312944106057 ICMT 1 GO:0023035 CD40 signaling pathway 1/803 15/18722 0.482019129810614 0.675312944106057 ITGB1 1 GO:0032328 alanine transport 1/803 15/18722 0.482019129810614 0.675312944106057 SLC38A2 1 GO:0032897 negative regulation of viral transcription 1/803 15/18722 0.482019129810614 0.675312944106057 IFITM3 1 GO:0032933 SREBP signaling pathway 1/803 15/18722 0.482019129810614 0.675312944106057 AMFR 1 GO:0033275 actin-myosin filament sliding 1/803 15/18722 0.482019129810614 0.675312944106057 TPM1 1 GO:0034380 high-density lipoprotein particle assembly 1/803 15/18722 0.482019129810614 0.675312944106057 APOE 1 GO:0034384 high-density lipoprotein particle clearance 1/803 15/18722 0.482019129810614 0.675312944106057 APOE 1 GO:0034638 phosphatidylcholine catabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 ENPP2 1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 1/803 15/18722 0.482019129810614 0.675312944106057 TWIST1 1 GO:0035493 SNARE complex assembly 1/803 15/18722 0.482019129810614 0.675312944106057 STXBP6 1 GO:0035627 ceramide transport 1/803 15/18722 0.482019129810614 0.675312944106057 PLTP 1 GO:0036124 histone H3-K9 trimethylation 1/803 15/18722 0.482019129810614 0.675312944106057 ATRX 1 GO:0042159 lipoprotein catabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 APOE 1 GO:0042976 activation of Janus kinase activity 1/803 15/18722 0.482019129810614 0.675312944106057 PRLR 1 GO:0043508 negative regulation of JUN kinase activity 1/803 15/18722 0.482019129810614 0.675312944106057 HIPK3 1 GO:0044793 negative regulation by host of viral process 1/803 15/18722 0.482019129810614 0.675312944106057 NUCKS1 1 GO:0045217 cell-cell junction maintenance 1/803 15/18722 0.482019129810614 0.675312944106057 TJP1 1 GO:0045836 positive regulation of meiotic nuclear division 1/803 15/18722 0.482019129810614 0.675312944106057 PLCB1 1 GO:0048484 enteric nervous system development 1/803 15/18722 0.482019129810614 0.675312944106057 EDNRB 1 GO:0050746 regulation of lipoprotein metabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 APOD 1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound 1/803 15/18722 0.482019129810614 0.675312944106057 COL11A1 1 GO:0051284 positive regulation of sequestering of calcium ion 1/803 15/18722 0.482019129810614 0.675312944106057 PKD2 1 GO:0051299 centrosome separation 1/803 15/18722 0.482019129810614 0.675312944106057 MAP9 1 GO:0051608 histamine transport 1/803 15/18722 0.482019129810614 0.675312944106057 SLC22A3 1 GO:0051791 medium-chain fatty acid metabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 CES1 1 GO:0051938 L-glutamate import 1/803 15/18722 0.482019129810614 0.675312944106057 ITGB1 1 GO:0060026 convergent extension 1/803 15/18722 0.482019129810614 0.675312944106057 PTK7 1 GO:0060046 regulation of acrosome reaction 1/803 15/18722 0.482019129810614 0.675312944106057 PLCB1 1 GO:0060099 regulation of phagocytosis, engulfment 1/803 15/18722 0.482019129810614 0.675312944106057 CD36 1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/803 15/18722 0.482019129810614 0.675312944106057 TNRC6C 1 GO:0070207 protein homotrimerization 1/803 15/18722 0.482019129810614 0.675312944106057 STEAP4 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/803 15/18722 0.482019129810614 0.675312944106057 PRNP 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/803 15/18722 0.482019129810614 0.675312944106057 LMCD1 1 GO:0071599 otic vesicle development 1/803 15/18722 0.482019129810614 0.675312944106057 CEP290 1 GO:0080154 regulation of fertilization 1/803 15/18722 0.482019129810614 0.675312944106057 PLCB1 1 GO:0090656 t-circle formation 1/803 15/18722 0.482019129810614 0.675312944106057 TERF1 1 GO:0090737 telomere maintenance via telomere trimming 1/803 15/18722 0.482019129810614 0.675312944106057 TERF1 1 GO:0098712 L-glutamate import across plasma membrane 1/803 15/18722 0.482019129810614 0.675312944106057 ITGB1 1 GO:0098760 response to interleukin-7 1/803 15/18722 0.482019129810614 0.675312944106057 LSP1 1 GO:0098761 cellular response to interleukin-7 1/803 15/18722 0.482019129810614 0.675312944106057 LSP1 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/803 15/18722 0.482019129810614 0.675312944106057 PLCB1 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/803 15/18722 0.482019129810614 0.675312944106057 PRNP 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/803 15/18722 0.482019129810614 0.675312944106057 LMCD1 1 GO:0150011 regulation of neuron projection arborization 1/803 15/18722 0.482019129810614 0.675312944106057 MACF1 1 GO:1900029 positive regulation of ruffle assembly 1/803 15/18722 0.482019129810614 0.675312944106057 EPS8 1 GO:1902018 negative regulation of cilium assembly 1/803 15/18722 0.482019129810614 0.675312944106057 YAP1 1 GO:1902902 negative regulation of autophagosome assembly 1/803 15/18722 0.482019129810614 0.675312944106057 NUPR1 1 GO:1903543 positive regulation of exosomal secretion 1/803 15/18722 0.482019129810614 0.675312944106057 SDC1 1 GO:1903727 positive regulation of phospholipid metabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 CAPN2 1 GO:1904251 regulation of bile acid metabolic process 1/803 15/18722 0.482019129810614 0.675312944106057 CES1 1 GO:1904380 endoplasmic reticulum mannose trimming 1/803 15/18722 0.482019129810614 0.675312944106057 AMFR 1 GO:1904424 regulation of GTP binding 1/803 15/18722 0.482019129810614 0.675312944106057 ARHGAP28 1 GO:1904889 regulation of excitatory synapse assembly 1/803 15/18722 0.482019129810614 0.675312944106057 PTPRD 1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1/803 15/18722 0.482019129810614 0.675312944106057 CAMK2D 1 GO:2001138 regulation of phospholipid transport 1/803 15/18722 0.482019129810614 0.675312944106057 APOE 1 GO:0017148 negative regulation of translation 11/803 245/18722 0.482037458498487 0.675312944106057 IGFBP5/TNRC6C/EIF4EBP1/ROCK2/ZFP36L2/ZFP36L1/AGO3/PURA/DAPK1/STAT3/EIF4EBP2 11 GO:0018105 peptidyl-serine phosphorylation 14/803 315/18722 0.484560442503225 0.678656844472213 HGF/GAS6/ANGPT1/PRKCA/PTEN/CAMK2D/PKD1/ROCK2/TGFBR2/HIPK3/WNK1/PRKAA1/HIPK1/ATM 14 GO:0009259 ribonucleotide metabolic process 17/803 385/18722 0.486385765644645 0.681022024011289 ENPP1/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 17 GO:0051402 neuron apoptotic process 11/803 246/18722 0.487482045126361 0.681329199643875 ITGA1/APOE/ANGPT1/MDK/LRP1/AXL/EGLN3/PRNP/NUPR1/FOXO3/GCLM 11 GO:0008637 apoptotic mitochondrial changes 5/803 107/18722 0.487483267746924 0.681329199643875 HGF/CLU/PLAUR/BNIP3L/GCLM 5 GO:0051341 regulation of oxidoreductase activity 5/803 107/18722 0.487483267746924 0.681329199643875 APOE/ACVR2A/ABL1/DDAH2/ZDHHC21 5 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 5/803 107/18722 0.487483267746924 0.681329199643875 PRICKLE1/PTEN/CLU/DAB2/HECTD1 5 GO:0002697 regulation of immune effector process 15/803 339/18722 0.488323719184734 0.681329199643875 SPON2/CD36/IL1R1/ANGPT1/HLA-B/SERPING1/HLA-A/CD81/B2M/A2M/BST2/HLA-F/FER/SERPINB9/NDFIP1 15 GO:0042440 pigment metabolic process 4/803 84/18722 0.488460536927745 0.681329199643875 ZEB2/BDH2/TSPO/PGRMC1 4 GO:0061157 mRNA destabilization 4/803 84/18722 0.488460536927745 0.681329199643875 TNRC6C/ROCK2/ZFP36L2/ZFP36L1 4 GO:0008210 estrogen metabolic process 2/803 38/18722 0.489260226775059 0.681329199643875 PDGFRA/HSD17B2 2 GO:0009309 amine biosynthetic process 2/803 38/18722 0.489260226775059 0.681329199643875 HAND2/NNMT 2 GO:0046329 negative regulation of JNK cascade 2/803 38/18722 0.489260226775059 0.681329199643875 HIPK3/ZMYND11 2 GO:0046676 negative regulation of insulin secretion 2/803 38/18722 0.489260226775059 0.681329199643875 IRS1/MAP4K4 2 GO:0048713 regulation of oligodendrocyte differentiation 2/803 38/18722 0.489260226775059 0.681329199643875 TMEM98/MDK 2 GO:0051930 regulation of sensory perception of pain 2/803 38/18722 0.489260226775059 0.681329199643875 SPX/EDNRB 2 GO:0072524 pyridine-containing compound metabolic process 2/803 38/18722 0.489260226775059 0.681329199643875 NNMT/NADK2 2 GO:0098926 postsynaptic signal transduction 2/803 38/18722 0.489260226775059 0.681329199643875 PLCB1/STAT3 2 GO:0099622 cardiac muscle cell membrane repolarization 2/803 38/18722 0.489260226775059 0.681329199643875 FLNA/ATP1B1 2 GO:1903725 regulation of phospholipid metabolic process 2/803 38/18722 0.489260226775059 0.681329199643875 LPIN1/CAPN2 2 GO:0006900 vesicle budding from membrane 3/803 61/18722 0.489279771055164 0.681329199643875 SEC31A/SAR1A/WASL 3 GO:1904356 regulation of telomere maintenance via telomere lengthening 3/803 61/18722 0.489279771055164 0.681329199643875 TERF1/NEK7/ATM 3 GO:0002696 positive regulation of leukocyte activation 18/803 409/18722 0.48971476079325 0.681329199643875 IGFBP2/VCAM1/THY1/GAS6/THBS1/IL6ST/IGF2/LGALS1/HLA-A/CD81/MDK/AXL/DPP4/B2M/TGFBR2/MAP3K8/HLA-F/ZMIZ1 18 GO:0002791 regulation of peptide secretion 9/803 200/18722 0.489748064886412 0.681329199643875 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 9 GO:0072522 purine-containing compound biosynthetic process 9/803 200/18722 0.489748064886412 0.681329199643875 GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/PID1/STAT3/PANK3/PAPSS1 9 GO:0099003 vesicle-mediated transport in synapse 9/803 200/18722 0.489748064886412 0.681329199643875 CASK/PTEN/STX2/STON1/AP2B1/PREPL/CLSTN1/CANX/ITSN1 9 GO:0051302 regulation of cell division 8/803 177/18722 0.491017307933545 0.682904406515106 FGF7/IGF2/MLLT3/MDK/TXNIP/CDC25B/MAP9/KLHL9 8 GO:0009314 response to radiation 20/803 456/18722 0.491808125945922 0.683813529271156 COL3A1/CCND2/MMP2/MFAP4/VCAM1/CRYAB/TIMP1/MEIS2/EXT1/PTPRK/PIK3R1/YAP1/ITGB1/NPTN/PRKAA1/IFI16/ATM/NUCKS1/CLOCK/USP47 20 GO:0018022 peptidyl-lysine methylation 6/803 131/18722 0.493952325396529 0.685630767511263 NNMT/KMT2A/ASH1L/ATRX/KMT2E/RTF1 6 GO:0032984 protein-containing complex disassembly 10/803 224/18722 0.494277563451845 0.685630767511263 MAP1B/PLEKHH2/LMOD1/SPTBN1/CFL2/EPS8/TAOK1/SETX/KLC1/GSN 10 GO:0042391 regulation of membrane potential 19/803 434/18722 0.496961789829838 0.685630767511263 DCN/FHL1/FXYD1/CD36/KCNMA1/GJA1/BIN1/FLNA/ATP1B1/PIEZO1/PTEN/CAMK2D/TSPO/PXK/ABL1/PID1/BNIP3L/SLC8A1/GCLM 19 GO:0030433 ubiquitin-dependent ERAD pathway 4/803 85/18722 0.497737401661471 0.685630767511263 MAN1A1/HSP90B1/AMFR/CANX 4 GO:0071277 cellular response to calcium ion 4/803 85/18722 0.497737401661471 0.685630767511263 CAMK2D/PKD2/WNK1/PRKAA1 4 GO:0002260 lymphocyte homeostasis 3/803 62/18722 0.5001702437481 0.685630767511263 ABL1/SKIL/SOS1 3 GO:0010573 vascular endothelial growth factor production 3/803 62/18722 0.5001702437481 0.685630767511263 GATA4/IL6ST/SULF2 3 GO:0032623 interleukin-2 production 3/803 62/18722 0.5001702437481 0.685630767511263 SPTBN1/PRNP/ABL1 3 GO:0032663 regulation of interleukin-2 production 3/803 62/18722 0.5001702437481 0.685630767511263 SPTBN1/PRNP/ABL1 3 GO:0045576 mast cell activation 3/803 62/18722 0.5001702437481 0.685630767511263 PTGDS/NDRG1/FER 3 GO:0046148 pigment biosynthetic process 3/803 62/18722 0.5001702437481 0.685630767511263 ZEB2/TSPO/PGRMC1 3 GO:0046824 positive regulation of nucleocytoplasmic transport 3/803 62/18722 0.5001702437481 0.685630767511263 GAS6/FLNA/PIK3R1 3 GO:0048488 synaptic vesicle endocytosis 3/803 62/18722 0.5001702437481 0.685630767511263 STON1/CANX/ITSN1 3 GO:0060113 inner ear receptor cell differentiation 3/803 62/18722 0.5001702437481 0.685630767511263 CTHRC1/BMP4/JAG1 3 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 3/803 62/18722 0.5001702437481 0.685630767511263 EPS8/AP2B1/CLSTN1 3 GO:0140238 presynaptic endocytosis 3/803 62/18722 0.5001702437481 0.685630767511263 STON1/CANX/ITSN1 3 GO:0090087 regulation of peptide transport 9/803 202/18722 0.501764166339503 0.685630767511263 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 9 GO:0016233 telomere capping 2/803 39/18722 0.503082957978612 0.685630767511263 NEK7/ATM 2 GO:0021587 cerebellum morphogenesis 2/803 39/18722 0.503082957978612 0.685630767511263 SERPINE2/ABL1 2 GO:0043267 negative regulation of potassium ion transport 2/803 39/18722 0.503082957978612 0.685630767511263 BIN1/PTEN 2 GO:0051931 regulation of sensory perception 2/803 39/18722 0.503082957978612 0.685630767511263 SPX/EDNRB 2 GO:0086091 regulation of heart rate by cardiac conduction 2/803 39/18722 0.503082957978612 0.685630767511263 BIN1/CAMK2D 2 GO:0090207 regulation of triglyceride metabolic process 2/803 39/18722 0.503082957978612 0.685630767511263 APOE/LPIN1 2 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 2/803 39/18722 0.503082957978612 0.685630767511263 CD81/TGFBR2 2 GO:1904951 positive regulation of establishment of protein localization 14/803 319/18722 0.503739013761071 0.685630767511263 GAS6/CAMK2N1/GJA1/FLNA/CD81/LRP1/PIK3R1/PRNP/NPEPPS/SAR1A/STOM/PRKAA1/MYO1C/CEP290 14 GO:0007626 locomotory behavior 8/803 179/18722 0.503779895794586 0.685630767511263 CCND2/PREX2/APOE/PTEN/DPP4/EPS8/NAV2/ZFHX3 8 GO:0032410 negative regulation of transporter activity 5/803 109/18722 0.503873328791257 0.685630767511263 PTEN/CAMK2D/PKD2/TWIST1/NDFIP1 5 GO:0001845 phagolysosome assembly 1/803 16/18722 0.504253514734015 0.685630767511263 SRPX 1 GO:0002371 dendritic cell cytokine production 1/803 16/18722 0.504253514734015 0.685630767511263 BST2 1 GO:0002399 MHC class II protein complex assembly 1/803 16/18722 0.504253514734015 0.685630767511263 B2M 1 GO:0002503 peptide antigen assembly with MHC class II protein complex 1/803 16/18722 0.504253514734015 0.685630767511263 B2M 1 GO:0002713 negative regulation of B cell mediated immunity 1/803 16/18722 0.504253514734015 0.685630767511263 NDFIP1 1 GO:0002827 positive regulation of T-helper 1 type immune response 1/803 16/18722 0.504253514734015 0.685630767511263 IL1R1 1 GO:0002830 positive regulation of type 2 immune response 1/803 16/18722 0.504253514734015 0.685630767511263 CD81 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/803 16/18722 0.504253514734015 0.685630767511263 NDFIP1 1 GO:0005980 glycogen catabolic process 1/803 16/18722 0.504253514734015 0.685630767511263 RB1CC1 1 GO:0006004 fucose metabolic process 1/803 16/18722 0.504253514734015 0.685630767511263 FUCA2 1 GO:0006349 regulation of gene expression by genetic imprinting 1/803 16/18722 0.504253514734015 0.685630767511263 IGF2 1 GO:0006740 NADPH regeneration 1/803 16/18722 0.504253514734015 0.685630767511263 H6PD 1 GO:0006750 glutathione biosynthetic process 1/803 16/18722 0.504253514734015 0.685630767511263 GCLM 1 GO:0006857 oligopeptide transport 1/803 16/18722 0.504253514734015 0.685630767511263 GJA1 1 GO:0007635 chemosensory behavior 1/803 16/18722 0.504253514734015 0.685630767511263 ADCY3 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/803 16/18722 0.504253514734015 0.685630767511263 XIST 1 GO:0009111 vitamin catabolic process 1/803 16/18722 0.504253514734015 0.685630767511263 CRABP1 1 GO:0009642 response to light intensity 1/803 16/18722 0.504253514734015 0.685630767511263 EXT1 1 GO:0010819 regulation of T cell chemotaxis 1/803 16/18722 0.504253514734015 0.685630767511263 WNK1 1 GO:0016584 nucleosome positioning 1/803 16/18722 0.504253514734015 0.685630767511263 RSF1 1 GO:0030540 female genitalia development 1/803 16/18722 0.504253514734015 0.685630767511263 AXL 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 1/803 16/18722 0.504253514734015 0.685630767511263 VTN 1 GO:0032274 gonadotropin secretion 1/803 16/18722 0.504253514734015 0.685630767511263 GJA1 1 GO:0034116 positive regulation of heterotypic cell-cell adhesion 1/803 16/18722 0.504253514734015 0.685630767511263 THY1 1 GO:0035067 negative regulation of histone acetylation 1/803 16/18722 0.504253514734015 0.685630767511263 TWIST1 1 GO:0035751 regulation of lysosomal lumen pH 1/803 16/18722 0.504253514734015 0.685630767511263 TMEM106B 1 GO:0042574 retinal metabolic process 1/803 16/18722 0.504253514734015 0.685630767511263 RDH10 1 GO:0042795 snRNA transcription by RNA polymerase II 1/803 16/18722 0.504253514734015 0.685630767511263 SNAPC3 1 GO:0043923 positive regulation by host of viral transcription 1/803 16/18722 0.504253514734015 0.685630767511263 NUCKS1 1 GO:0044065 regulation of respiratory system process 1/803 16/18722 0.504253514734015 0.685630767511263 GLS 1 GO:0044804 autophagy of nucleus 1/803 16/18722 0.504253514734015 0.685630767511263 RB1CC1 1 GO:0045722 positive regulation of gluconeogenesis 1/803 16/18722 0.504253514734015 0.685630767511263 NNMT 1 GO:0045779 negative regulation of bone resorption 1/803 16/18722 0.504253514734015 0.685630767511263 GPR137B 1 GO:0050862 positive regulation of T cell receptor signaling pathway 1/803 16/18722 0.504253514734015 0.685630767511263 CD81 1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 1/803 16/18722 0.504253514734015 0.685630767511263 APOE 1 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 1/803 16/18722 0.504253514734015 0.685630767511263 AKAP12 1 GO:0061548 ganglion development 1/803 16/18722 0.504253514734015 0.685630767511263 NRP2 1 GO:0070200 establishment of protein localization to telomere 1/803 16/18722 0.504253514734015 0.685630767511263 TERF1 1 GO:0070242 thymocyte apoptotic process 1/803 16/18722 0.504253514734015 0.685630767511263 BMP4 1 GO:0071391 cellular response to estrogen stimulus 1/803 16/18722 0.504253514734015 0.685630767511263 SERPINB9 1 GO:0071501 cellular response to sterol depletion 1/803 16/18722 0.504253514734015 0.685630767511263 AMFR 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/803 16/18722 0.504253514734015 0.685630767511263 TWIST1 1 GO:0072283 metanephric renal vesicle morphogenesis 1/803 16/18722 0.504253514734015 0.685630767511263 BMP4 1 GO:0090336 positive regulation of brown fat cell differentiation 1/803 16/18722 0.504253514734015 0.685630767511263 METRNL 1 GO:0097202 activation of cysteine-type endopeptidase activity 1/803 16/18722 0.504253514734015 0.685630767511263 IFI16 1 GO:0097284 hepatocyte apoptotic process 1/803 16/18722 0.504253514734015 0.685630767511263 GSN 1 GO:0098884 postsynaptic neurotransmitter receptor internalization 1/803 16/18722 0.504253514734015 0.685630767511263 AP2B1 1 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 1/803 16/18722 0.504253514734015 0.685630767511263 CLSTN1 1 GO:0099010 modification of postsynaptic structure 1/803 16/18722 0.504253514734015 0.685630767511263 ITSN1 1 GO:0099116 tRNA 5'-end processing 1/803 16/18722 0.504253514734015 0.685630767511263 RPP25 1 GO:0140239 postsynaptic endocytosis 1/803 16/18722 0.504253514734015 0.685630767511263 AP2B1 1 GO:1902306 negative regulation of sodium ion transmembrane transport 1/803 16/18722 0.504253514734015 0.685630767511263 CAMK2D 1 GO:1905153 regulation of membrane invagination 1/803 16/18722 0.504253514734015 0.685630767511263 CD36 1 GO:1905874 regulation of postsynaptic density organization 1/803 16/18722 0.504253514734015 0.685630767511263 PTPRD 1 GO:0048193 Golgi vesicle transport 13/803 296/18722 0.505386207439266 0.686944132278821 STXBP6/MYO1B/COPZ2/GAS1/PLPP3/SPTBN1/SEC31A/MON2/PREPL/SAR1A/SORT1/MACF1/GOLGA4 13 GO:0002703 regulation of leukocyte mediated immunity 10/803 226/18722 0.50563276483419 0.686944132278821 IL1R1/HLA-B/HLA-A/CD81/B2M/BST2/HLA-F/FER/SERPINB9/NDFIP1 10 GO:0071241 cellular response to inorganic substance 10/803 226/18722 0.50563276483419 0.686944132278821 CLDN1/SERPINF1/CAMK2D/B2M/PKD2/TSPO/PRNP/WNK1/ATRX/PRKAA1 10 GO:0046631 alpha-beta T cell activation 7/803 156/18722 0.506077556956381 0.68736112748148 TMEM98/TWSG1/HLA-A/CD81/TGFBR2/ABL1/STAT3 7 GO:0046942 carboxylic acid transport 12/803 273/18722 0.507172260318742 0.688660373079861 PLA2G2A/SLC22A3/CD36/GJA1/CES1/SLC16A7/SERINC3/ITGB1/SLC38A2/PLA2R1/PRKAA1/SERINC5 12 GO:0009895 negative regulation of catabolic process 14/803 320/18722 0.508508811498104 0.690251203932167 HGF/GATA4/SERPINE2/TIMP1/FLNA/LAPTM4B/TIMP3/PDE3B/TSPO/NUPR1/TIMP2/STAT3/PRKAA1/CTSA 14 GO:0006997 nucleus organization 6/803 133/18722 0.508759160539654 0.690251203932167 BIN1/PRKCA/LPIN1/PLEC/SYNE1/RTN4 6 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 6/803 133/18722 0.508759160539654 0.690251203932167 PRICKLE1/PTEN/CLU/NUPR1/DAB2/HECTD1 6 GO:0001756 somitogenesis 3/803 63/18722 0.510941267526541 0.692458048352088 LRP6/EPB41L5/MIB1 3 GO:0016239 positive regulation of macroautophagy 3/803 63/18722 0.510941267526541 0.692458048352088 DCN/SESN3/BNIP3L 3 GO:0045143 homologous chromosome segregation 3/803 63/18722 0.510941267526541 0.692458048352088 MAEL/P3H4/TERF1 3 GO:2000756 regulation of peptidyl-lysine acetylation 3/803 63/18722 0.510941267526541 0.692458048352088 TWIST1/KMT2A/PRKAA1 3 GO:0018958 phenol-containing compound metabolic process 5/803 110/18722 0.511991078828397 0.693692260608258 SLC16A10/HAND2/CTSK/ZEB2/EPAS1 5 GO:1902600 proton transmembrane transport 7/803 157/18722 0.512866564704493 0.694689674440804 CLCN5/SLC2A10/SLC9A9/COX7A1/TWIST1/TMCO3/ACTN4 7 GO:0061014 positive regulation of mRNA catabolic process 4/803 87/18722 0.516069194225806 0.697933586732459 TNRC6C/ROCK2/ZFP36L2/ZFP36L1 4 GO:1900182 positive regulation of protein localization to nucleus 4/803 87/18722 0.516069194225806 0.697933586732459 FLNA/GLIS2/PIK3R1/YAP1 4 GO:0002705 positive regulation of leukocyte mediated immunity 6/803 134/18722 0.516102797326762 0.697933586732459 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F 6 GO:0006479 protein methylation 8/803 181/18722 0.516442630707697 0.697933586732459 NNMT/PRDM6/KMT2A/ASH1L/ATRX/KMT2E/RTF1/ICMT 8 GO:0008213 protein alkylation 8/803 181/18722 0.516442630707697 0.697933586732459 NNMT/PRDM6/KMT2A/ASH1L/ATRX/KMT2E/RTF1/ICMT 8 GO:0009187 cyclic nucleotide metabolic process 2/803 40/18722 0.516661225156339 0.697933586732459 GUCY1A2/ADCY3 2 GO:0031111 negative regulation of microtubule polymerization or depolymerization 2/803 40/18722 0.516661225156339 0.697933586732459 MAP1B/TAOK1 2 GO:0032094 response to food 2/803 40/18722 0.516661225156339 0.697933586732459 SPX/PLEC 2 GO:0032892 positive regulation of organic acid transport 2/803 40/18722 0.516661225156339 0.697933586732459 ITGB1/PLA2R1 2 GO:0044275 cellular carbohydrate catabolic process 2/803 40/18722 0.516661225156339 0.697933586732459 SCARB2/RB1CC1 2 GO:0043488 regulation of mRNA stability 7/803 158/18722 0.519622679858217 0.700994016763339 PRKCA/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/PUM2 7 GO:0006749 glutathione metabolic process 3/803 64/18722 0.521588493504184 0.700994016763339 GLO1/GSTM3/GCLM 3 GO:0030104 water homeostasis 3/803 64/18722 0.521588493504184 0.700994016763339 CLDN1/EXT1/PLEC 3 GO:0046888 negative regulation of hormone secretion 3/803 64/18722 0.521588493504184 0.700994016763339 GJA1/IRS1/MAP4K4 3 GO:0048247 lymphocyte chemotaxis 3/803 64/18722 0.521588493504184 0.700994016763339 GAS6/PLEC/WNK1 3 GO:0048857 neural nucleus development 3/803 64/18722 0.521588493504184 0.700994016763339 NFIB/BASP1/ZNF148 3 GO:0098930 axonal transport 3/803 64/18722 0.521588493504184 0.700994016763339 DST/ARMCX3/HSPB1 3 GO:0009581 detection of external stimulus 6/803 135/18722 0.523403992746098 0.700994016763339 COL11A1/SERPINE2/PIEZO1/PKD1/PKD2/TMEM120A 6 GO:0042157 lipoprotein metabolic process 6/803 135/18722 0.523403992746098 0.700994016763339 APOD/APOE/LRP1/APOL1/APOL6/ZDHHC21 6 GO:0061982 meiosis I cell cycle process 6/803 135/18722 0.523403992746098 0.700994016763339 MAEL/HSPA2/CDC25B/P3H4/TERF1/ATM 6 GO:0016050 vesicle organization 13/803 300/18722 0.525096152246351 0.700994016763339 SRPX/STXBP6/SERPINE2/ZEB2/LAPTM4B/STX2/SCARB2/SEC31A/SDC1/SAR1A/WASL/SORT1/STAM2 13 GO:0007260 tyrosine phosphorylation of STAT protein 4/803 88/18722 0.525117639299056 0.700994016763339 IL6ST/SOCS3/TNFRSF1A/FER 4 GO:0009144 purine nucleoside triphosphate metabolic process 4/803 88/18722 0.525117639299056 0.700994016763339 RAB23/RHOQ/PID1/STAT3 4 GO:0031110 regulation of microtubule polymerization or depolymerization 4/803 88/18722 0.525117639299056 0.700994016763339 MAP1B/NIN/ABL1/TAOK1 4 GO:0050779 RNA destabilization 4/803 88/18722 0.525117639299056 0.700994016763339 TNRC6C/ROCK2/ZFP36L2/ZFP36L1 4 GO:0001780 neutrophil homeostasis 1/803 17/18722 0.525534623879134 0.700994016763339 AXL 1 GO:0006577 amino-acid betaine metabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 ALDH9A1 1 GO:0006677 glycosylceramide metabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 PRKAA1 1 GO:0006901 vesicle coating 1/803 17/18722 0.525534623879134 0.700994016763339 SAR1A 1 GO:0007379 segment specification 1/803 17/18722 0.525534623879134 0.700994016763339 MLLT3 1 GO:0008334 histone mRNA metabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 ATM 1 GO:0009251 glucan catabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 RB1CC1 1 GO:0010224 response to UV-B 1/803 17/18722 0.525534623879134 0.700994016763339 MFAP4 1 GO:0010470 regulation of gastrulation 1/803 17/18722 0.525534623879134 0.700994016763339 PHLDB1 1 GO:0010831 positive regulation of myotube differentiation 1/803 17/18722 0.525534623879134 0.700994016763339 PIEZO1 1 GO:0015867 ATP transport 1/803 17/18722 0.525534623879134 0.700994016763339 GJA1 1 GO:0016264 gap junction assembly 1/803 17/18722 0.525534623879134 0.700994016763339 GJA1 1 GO:0020027 hemoglobin metabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 KLF4 1 GO:0030002 cellular anion homeostasis 1/803 17/18722 0.525534623879134 0.700994016763339 ENPP1 1 GO:0030903 notochord development 1/803 17/18722 0.525534623879134 0.700994016763339 YAP1 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/803 17/18722 0.525534623879134 0.700994016763339 ATM 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/803 17/18722 0.525534623879134 0.700994016763339 SOCS3 1 GO:0045815 positive regulation of gene expression, epigenetic 1/803 17/18722 0.525534623879134 0.700994016763339 ZMIZ1 1 GO:0046068 cGMP metabolic process 1/803 17/18722 0.525534623879134 0.700994016763339 GUCY1A2 1 GO:0046827 positive regulation of protein export from nucleus 1/803 17/18722 0.525534623879134 0.700994016763339 GAS6 1 GO:0046855 inositol phosphate dephosphorylation 1/803 17/18722 0.525534623879134 0.700994016763339 PTEN 1 GO:0048532 anatomical structure arrangement 1/803 17/18722 0.525534623879134 0.700994016763339 NRP2 1 GO:0051580 regulation of neurotransmitter uptake 1/803 17/18722 0.525534623879134 0.700994016763339 ITGB1 1 GO:0051797 regulation of hair follicle development 1/803 17/18722 0.525534623879134 0.700994016763339 FST 1 GO:0090136 epithelial cell-cell adhesion 1/803 17/18722 0.525534623879134 0.700994016763339 VCL 1 GO:0090494 dopamine uptake 1/803 17/18722 0.525534623879134 0.700994016763339 SLC22A3 1 GO:0090713 immunological memory process 1/803 17/18722 0.525534623879134 0.700994016763339 CD81 1 GO:0097067 cellular response to thyroid hormone stimulus 1/803 17/18722 0.525534623879134 0.700994016763339 GCLM 1 GO:1900034 regulation of cellular response to heat 1/803 17/18722 0.525534623879134 0.700994016763339 ATM 1 GO:1903540 establishment of protein localization to postsynaptic membrane 1/803 17/18722 0.525534623879134 0.700994016763339 CLSTN1 1 GO:1903541 regulation of exosomal secretion 1/803 17/18722 0.525534623879134 0.700994016763339 SDC1 1 GO:1904355 positive regulation of telomere capping 1/803 17/18722 0.525534623879134 0.700994016763339 NEK7 1 GO:0048285 organelle fission 21/803 488/18722 0.525828373033056 0.701198252993533 DCN/PDE3A/PDGFRB/HOXA13/MAEL/BMP4/FLNA/IGF2/CCDC8/HSPA2/PLCB1/EPS8/CDC25B/PRKAR1A/MAP9/PDS5B/ATRX/EML4/P3H4/TERF1/ATM 21 GO:0009141 nucleoside triphosphate metabolic process 5/803 112/18722 0.528059637698277 0.703876653827536 ENPP1/RAB23/RHOQ/PID1/STAT3 5 GO:0016197 endosomal transport 10/803 230/18722 0.528119246283356 0.703876653827536 EHD2/ANKRD50/LAPTM4B/PREPL/TMEM87A/ACAP2/EVI5/SORT1/CLTC/ITSN1 10 GO:0002819 regulation of adaptive immune response 8/803 183/18722 0.52899488048685 0.704675435998556 IL1R1/IL6ST/HLA-B/HLA-A/CD81/B2M/HLA-F/NDFIP1 8 GO:0009167 purine ribonucleoside monophosphate metabolic process 2/803 41/18722 0.52999055054043 0.704675435998556 CASK/MAGI3 2 GO:0032733 positive regulation of interleukin-10 production 2/803 41/18722 0.52999055054043 0.704675435998556 HGF/STAT3 2 GO:0042307 positive regulation of protein import into nucleus 2/803 41/18722 0.52999055054043 0.704675435998556 FLNA/PIK3R1 2 GO:0044786 cell cycle DNA replication 2/803 41/18722 0.52999055054043 0.704675435998556 ATRX/TERF1 2 GO:0060612 adipose tissue development 2/803 41/18722 0.52999055054043 0.704675435998556 CSF1/ARID5B 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/803 41/18722 0.52999055054043 0.704675435998556 CAMK2D/SLC8A1 2 GO:1902116 negative regulation of organelle assembly 2/803 41/18722 0.52999055054043 0.704675435998556 YAP1/NUPR1 2 GO:1903524 positive regulation of blood circulation 2/803 41/18722 0.52999055054043 0.704675435998556 PTGER2/TPM1 2 GO:0009165 nucleotide biosynthetic process 11/803 254/18722 0.530511109242624 0.7051795229762 NNMT/GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/NADK2/PID1/STAT3/PANK3/PAPSS1 11 GO:0016064 immunoglobulin mediated immune response 9/803 207/18722 0.531427385200329 0.70620920645225 C7/C1R/C1S/C2/SERPING1/CD81/B2M/CLU/NDFIP1 9 GO:0045682 regulation of epidermis development 3/803 65/18722 0.532107930238543 0.706925163914036 BMP4/ROCK2/ZFP36L1 3 GO:0060402 calcium ion transport into cytosol 7/803 160/18722 0.533030090145727 0.707961648765742 THY1/CAMK2D/PKD2/PRNP/ABL1/TPCN1/SLC8A1 7 GO:0006163 purine nucleotide metabolic process 17/803 396/18722 0.533870329081303 0.70860607823804 ENPP1/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 17 GO:0019693 ribose phosphate metabolic process 17/803 396/18722 0.533870329081303 0.70860607823804 ENPP1/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 17 GO:0009199 ribonucleoside triphosphate metabolic process 4/803 89/18722 0.534083762939942 0.70860607823804 RAB23/RHOQ/PID1/STAT3 4 GO:0051781 positive regulation of cell division 4/803 89/18722 0.534083762939942 0.70860607823804 FGF7/IGF2/MDK/CDC25B 4 GO:0007051 spindle organization 8/803 184/18722 0.535226398836677 0.70993318026062 FLNA/PKD1/GNAI1/MAP9/ATRX/SBDS/CLTC/NEK7 8 GO:0002263 cell activation involved in immune response 12/803 279/18722 0.537817563741635 0.712532395259376 PTGDS/TMEM98/LGALS1/CD81/MDK/LRP1/NOTCH2/ABL1/HLA-F/STAT3/FER/NDFIP1 12 GO:0006417 regulation of translation 20/803 468/18722 0.539473802494014 0.712532395259376 IGFBP5/THBS1/TNRC6C/VIM/LTN1/EIF4EBP1/ROCK2/ZFP36L2/ZFP36L1/EIF4G3/AGO3/EIF4A2/PURA/DAPK1/PLXNB2/FOXO3/STAT3/EIF4EBP2/PUM2/HSPB1 20 GO:1901293 nucleoside phosphate biosynthetic process 11/803 256/18722 0.541090386317319 0.712532395259376 NNMT/GUCY1A2/ELOVL2/ADCY3/PAPSS2/PDK4/NADK2/PID1/STAT3/PANK3/PAPSS1 11 GO:0002831 regulation of response to biotic stimulus 14/803 327/18722 0.541550435938825 0.712532395259376 GATA6/CD36/APOE/PRKCA/HLA-B/SERPING1/HLA-A/HTRA1/A2M/HLA-F/IFI16/PUM2/SERPINB9/TSPAN6 14 GO:1905953 negative regulation of lipid localization 3/803 66/18722 0.542495931180149 0.712532395259376 THBS1/CES1/PLA2R1 3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 4/803 90/18722 0.5429647708554 0.712532395259376 PRICKLE1/CLU/DAB2/HECTD1 4 GO:0048477 oogenesis 4/803 90/18722 0.5429647708554 0.712532395259376 PDE3A/MDK/CDC25B/FOXO3 4 GO:0061097 regulation of protein tyrosine kinase activity 4/803 90/18722 0.5429647708554 0.712532395259376 THY1/GAS6/PRNP/RAP2B 4 GO:0007212 dopamine receptor signaling pathway 2/803 42/18722 0.543067288740431 0.712532395259376 PALM/FLNA 2 GO:0010939 regulation of necrotic cell death 2/803 42/18722 0.543067288740431 0.712532395259376 TSPO/NUPR1 2 GO:0019432 triglyceride biosynthetic process 2/803 42/18722 0.543067288740431 0.712532395259376 LPGAT1/LPIN1 2 GO:0046688 response to copper ion 2/803 42/18722 0.543067288740431 0.712532395259376 SOD3/PRNP 2 GO:0060999 positive regulation of dendritic spine development 2/803 42/18722 0.543067288740431 0.712532395259376 APOE/ITSN1 2 GO:0019751 polyol metabolic process 5/803 114/18722 0.543890330984217 0.712532395259376 PLPP1/PLPP3/PTEN/SLC5A3/IPMK 5 GO:1901800 positive regulation of proteasomal protein catabolic process 5/803 114/18722 0.543890330984217 0.712532395259376 PRICKLE1/CLU/NUPR1/DAB2/HECTD1 5 GO:1903008 organelle disassembly 5/803 114/18722 0.543890330984217 0.712532395259376 CTSK/TSPO/KLC1/BNIP3L/RB1CC1 5 GO:0009582 detection of abiotic stimulus 6/803 138/18722 0.54503471253115 0.712532395259376 COL11A1/SERPINE2/PIEZO1/PKD1/PKD2/TMEM120A 6 GO:0002295 T-helper cell lineage commitment 1/803 18/18722 0.545903279159811 0.712532395259376 STAT3 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/803 18/18722 0.545903279159811 0.712532395259376 B2M 1 GO:0006085 acetyl-CoA biosynthetic process 1/803 18/18722 0.545903279159811 0.712532395259376 PDK4 1 GO:0006595 polyamine metabolic process 1/803 18/18722 0.545903279159811 0.712532395259376 NNMT 1 GO:0006991 response to sterol depletion 1/803 18/18722 0.545903279159811 0.712532395259376 AMFR 1 GO:0007250 activation of NF-kappaB-inducing kinase activity 1/803 18/18722 0.545903279159811 0.712532395259376 COPS8 1 GO:0007549 dosage compensation 1/803 18/18722 0.545903279159811 0.712532395259376 XIST 1 GO:0015936 coenzyme A metabolic process 1/803 18/18722 0.545903279159811 0.712532395259376 PANK3 1 GO:0019896 axonal transport of mitochondrion 1/803 18/18722 0.545903279159811 0.712532395259376 ARMCX3 1 GO:0030299 intestinal cholesterol absorption 1/803 18/18722 0.545903279159811 0.712532395259376 CD36 1 GO:0030730 sequestering of triglyceride 1/803 18/18722 0.545903279159811 0.712532395259376 ENPP1 1 GO:0030889 negative regulation of B cell proliferation 1/803 18/18722 0.545903279159811 0.712532395259376 ATM 1 GO:0031643 positive regulation of myelination 1/803 18/18722 0.545903279159811 0.712532395259376 HGF 1 GO:0031649 heat generation 1/803 18/18722 0.545903279159811 0.712532395259376 EDNRB 1 GO:0032095 regulation of response to food 1/803 18/18722 0.545903279159811 0.712532395259376 SPX 1 GO:0032305 positive regulation of icosanoid secretion 1/803 18/18722 0.545903279159811 0.712532395259376 PLA2R1 1 GO:0034162 toll-like receptor 9 signaling pathway 1/803 18/18722 0.545903279159811 0.712532395259376 RTN4 1 GO:0034433 steroid esterification 1/803 18/18722 0.545903279159811 0.712532395259376 APOE 1 GO:0034434 sterol esterification 1/803 18/18722 0.545903279159811 0.712532395259376 APOE 1 GO:0034435 cholesterol esterification 1/803 18/18722 0.545903279159811 0.712532395259376 APOE 1 GO:0034587 piRNA metabolic process 1/803 18/18722 0.545903279159811 0.712532395259376 MAEL 1 GO:0042136 neurotransmitter biosynthetic process 1/803 18/18722 0.545903279159811 0.712532395259376 ALDH9A1 1 GO:0042693 muscle cell fate commitment 1/803 18/18722 0.545903279159811 0.712532395259376 TBX2 1 GO:0044247 cellular polysaccharide catabolic process 1/803 18/18722 0.545903279159811 0.712532395259376 RB1CC1 1 GO:0045116 protein neddylation 1/803 18/18722 0.545903279159811 0.712532395259376 EPAS1 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/803 18/18722 0.545903279159811 0.712532395259376 PTGDS 1 GO:0046838 phosphorylated carbohydrate dephosphorylation 1/803 18/18722 0.545903279159811 0.712532395259376 PTEN 1 GO:0046851 negative regulation of bone remodeling 1/803 18/18722 0.545903279159811 0.712532395259376 GPR137B 1 GO:0050665 hydrogen peroxide biosynthetic process 1/803 18/18722 0.545903279159811 0.712532395259376 STAT3 1 GO:0051447 negative regulation of meiotic cell cycle 1/803 18/18722 0.545903279159811 0.712532395259376 PRKAR1A 1 GO:0051782 negative regulation of cell division 1/803 18/18722 0.545903279159811 0.712532395259376 TXNIP 1 GO:0055070 copper ion homeostasis 1/803 18/18722 0.545903279159811 0.712532395259376 PRNP 1 GO:0060457 negative regulation of digestive system process 1/803 18/18722 0.545903279159811 0.712532395259376 WNK1 1 GO:0060716 labyrinthine layer blood vessel development 1/803 18/18722 0.545903279159811 0.712532395259376 WNT2 1 GO:0060749 mammary gland alveolus development 1/803 18/18722 0.545903279159811 0.712532395259376 SOCS2 1 GO:0061377 mammary gland lobule development 1/803 18/18722 0.545903279159811 0.712532395259376 SOCS2 1 GO:0071318 cellular response to ATP 1/803 18/18722 0.545903279159811 0.712532395259376 HSP90B1 1 GO:0090493 catecholamine uptake 1/803 18/18722 0.545903279159811 0.712532395259376 SLC22A3 1 GO:0098877 neurotransmitter receptor transport to plasma membrane 1/803 18/18722 0.545903279159811 0.712532395259376 CLSTN1 1 GO:0150078 positive regulation of neuroinflammatory response 1/803 18/18722 0.545903279159811 0.712532395259376 NUPR1 1 GO:1900225 regulation of NLRP3 inflammasome complex assembly 1/803 18/18722 0.545903279159811 0.712532395259376 CD36 1 GO:1902683 regulation of receptor localization to synapse 1/803 18/18722 0.545903279159811 0.712532395259376 NPTN 1 GO:1903209 positive regulation of oxidative stress-induced cell death 1/803 18/18722 0.545903279159811 0.712532395259376 FOXO3 1 GO:2001135 regulation of endocytic recycling 1/803 18/18722 0.545903279159811 0.712532395259376 EHD2 1 GO:0051100 negative regulation of binding 7/803 162/18722 0.546287972942696 0.712847901882304 HAND2/B2M/RSF1/ARHGAP28/DAB2/EPB41L5/IFI16 7 GO:0019724 B cell mediated immunity 9/803 210/18722 0.548922868221631 0.716098749595252 C7/C1R/C1S/C2/SERPING1/CD81/B2M/CLU/NDFIP1 9 GO:0006885 regulation of pH 4/803 91/18722 0.551758041655156 0.719420919375682 EDNRB/PDK4/SLC9A9/TMEM106B 4 GO:0042147 retrograde transport, endosome to Golgi 4/803 91/18722 0.551758041655156 0.719420919375682 PREPL/TMEM87A/EVI5/CLTC 4 GO:0032890 regulation of organic acid transport 3/803 67/18722 0.55274918210954 0.719772113345042 THBS1/ITGB1/PLA2R1 3 GO:0042490 mechanoreceptor differentiation 3/803 67/18722 0.55274918210954 0.719772113345042 CTHRC1/BMP4/JAG1 3 GO:0046635 positive regulation of alpha-beta T cell activation 3/803 67/18722 0.55274918210954 0.719772113345042 HLA-A/CD81/TGFBR2 3 GO:0048814 regulation of dendrite morphogenesis 3/803 67/18722 0.55274918210954 0.719772113345042 PTPRD/SDC2/RAP2A 3 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 3/803 67/18722 0.55274918210954 0.719772113345042 TWSG1/CD81/TGFBR2 3 GO:0001504 neurotransmitter uptake 2/803 43/18722 0.555888563738692 0.72216268337705 SLC22A3/ITGB1 2 GO:0009268 response to pH 2/803 43/18722 0.555888563738692 0.72216268337705 GJA1/SERPINF1 2 GO:0016266 O-glycan processing 2/803 43/18722 0.555888563738692 0.72216268337705 GXYLT2/GALNT1 2 GO:0036230 granulocyte activation 2/803 43/18722 0.555888563738692 0.72216268337705 PLA2G2A/KMT2E 2 GO:0042088 T-helper 1 type immune response 2/803 43/18722 0.555888563738692 0.72216268337705 IL1R1/TMEM98 2 GO:0046717 acid secretion 2/803 43/18722 0.555888563738692 0.72216268337705 CES1/PRKAA1 2 GO:0090278 negative regulation of peptide hormone secretion 2/803 43/18722 0.555888563738692 0.72216268337705 IRS1/MAP4K4 2 GO:1903793 positive regulation of anion transport 2/803 43/18722 0.555888563738692 0.72216268337705 ITGB1/PLA2R1 2 GO:1904591 positive regulation of protein import 2/803 43/18722 0.555888563738692 0.72216268337705 FLNA/PIK3R1 2 GO:0015748 organophosphate ester transport 6/803 140/18722 0.559210769195184 0.72624287207882 PLSCR4/APOE/GJA1/PLTP/SCARB2/NPC2 6 GO:0033559 unsaturated fatty acid metabolic process 5/803 116/18722 0.559466279914711 0.72624287207882 PTGDS/ELOVL2/ZADH2/TNFRSF1A/FADS3 5 GO:0035967 cellular response to topologically incorrect protein 5/803 116/18722 0.559466279914711 0.72624287207882 CREB3L1/HSPA2/PIK3R1/AMFR/MBTPS1 5 GO:0009988 cell-cell recognition 3/803 68/18722 0.562864688604452 0.727128502080489 CD9/CD81/MSN 3 GO:0032922 circadian regulation of gene expression 3/803 68/18722 0.562864688604452 0.727128502080489 KMT2A/ZFHX3/CLOCK 3 GO:0046686 response to cadmium ion 3/803 68/18722 0.562864688604452 0.727128502080489 SPARC/B2M/PRNP 3 GO:0002396 MHC protein complex assembly 1/803 19/18722 0.565398556471331 0.727128502080489 B2M 1 GO:0002523 leukocyte migration involved in inflammatory response 1/803 19/18722 0.565398556471331 0.727128502080489 MDK 1 GO:0002902 regulation of B cell apoptotic process 1/803 19/18722 0.565398556471331 0.727128502080489 PTEN 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/803 19/18722 0.565398556471331 0.727128502080489 BMPR2 1 GO:0006491 N-glycan processing 1/803 19/18722 0.565398556471331 0.727128502080489 MAN1A1 1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1/803 19/18722 0.565398556471331 0.727128502080489 ATM 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/803 19/18722 0.565398556471331 0.727128502080489 PLCB1 1 GO:0007530 sex determination 1/803 19/18722 0.565398556471331 0.727128502080489 TCF21 1 GO:0008356 asymmetric cell division 1/803 19/18722 0.565398556471331 0.727128502080489 SOX5 1 GO:0009301 snRNA transcription 1/803 19/18722 0.565398556471331 0.727128502080489 SNAPC3 1 GO:0030011 maintenance of cell polarity 1/803 19/18722 0.565398556471331 0.727128502080489 DST 1 GO:0032026 response to magnesium ion 1/803 19/18722 0.565398556471331 0.727128502080489 THBS1 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/803 19/18722 0.565398556471331 0.727128502080489 ELOVL2 1 GO:0035461 vitamin transmembrane transport 1/803 19/18722 0.565398556471331 0.727128502080489 SLC19A3 1 GO:0043652 engulfment of apoptotic cell 1/803 19/18722 0.565398556471331 0.727128502080489 THBS1 1 GO:0044003 modulation by symbiont of host process 1/803 19/18722 0.565398556471331 0.727128502080489 SERPINB9 1 GO:0044546 NLRP3 inflammasome complex assembly 1/803 19/18722 0.565398556471331 0.727128502080489 CD36 1 GO:0045603 positive regulation of endothelial cell differentiation 1/803 19/18722 0.565398556471331 0.727128502080489 BMP4 1 GO:0045821 positive regulation of glycolytic process 1/803 19/18722 0.565398556471331 0.727128502080489 PRKAA1 1 GO:0046716 muscle cell cellular homeostasis 1/803 19/18722 0.565398556471331 0.727128502080489 CFL2 1 GO:0051444 negative regulation of ubiquitin-protein transferase activity 1/803 19/18722 0.565398556471331 0.727128502080489 ABL1 1 GO:0051957 positive regulation of amino acid transport 1/803 19/18722 0.565398556471331 0.727128502080489 ITGB1 1 GO:0060065 uterus development 1/803 19/18722 0.565398556471331 0.727128502080489 ASH1L 1 GO:0061760 antifungal innate immune response 1/803 19/18722 0.565398556471331 0.727128502080489 RARRES2 1 GO:0062099 negative regulation of programmed necrotic cell death 1/803 19/18722 0.565398556471331 0.727128502080489 NUPR1 1 GO:0070233 negative regulation of T cell apoptotic process 1/803 19/18722 0.565398556471331 0.727128502080489 BMP4 1 GO:0071545 inositol phosphate catabolic process 1/803 19/18722 0.565398556471331 0.727128502080489 PTEN 1 GO:0072077 renal vesicle morphogenesis 1/803 19/18722 0.565398556471331 0.727128502080489 BMP4 1 GO:0140131 positive regulation of lymphocyte chemotaxis 1/803 19/18722 0.565398556471331 0.727128502080489 WNK1 1 GO:1901881 positive regulation of protein depolymerization 1/803 19/18722 0.565398556471331 0.727128502080489 CFL2 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/803 19/18722 0.565398556471331 0.727128502080489 ABL1 1 GO:2000269 regulation of fibroblast apoptotic process 1/803 19/18722 0.565398556471331 0.727128502080489 GAS6 1 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 1/803 19/18722 0.565398556471331 0.727128502080489 HLA-A 1 GO:0002792 negative regulation of peptide secretion 2/803 44/18722 0.568452209748106 0.729926015401508 IRS1/MAP4K4 2 GO:0009126 purine nucleoside monophosphate metabolic process 2/803 44/18722 0.568452209748106 0.729926015401508 CASK/MAGI3 2 GO:0021762 substantia nigra development 2/803 44/18722 0.568452209748106 0.729926015401508 BASP1/ZNF148 2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 2/803 44/18722 0.568452209748106 0.729926015401508 PTK7/MSN 2 GO:0150076 neuroinflammatory response 2/803 44/18722 0.568452209748106 0.729926015401508 NUPR1/ITGB1 2 GO:1903573 negative regulation of response to endoplasmic reticulum stress 2/803 44/18722 0.568452209748106 0.729926015401508 CREB3L1/CLU 2 GO:0019217 regulation of fatty acid metabolic process 4/803 93/18722 0.569071729424287 0.730345339230243 IRS1/PDK4/LPGAT1/TWIST1 4 GO:0032755 positive regulation of interleukin-6 production 4/803 93/18722 0.569071729424287 0.730345339230243 SPON2/CD36/TWIST1/STAT3 4 GO:0009566 fertilization 8/803 190/18722 0.571916964956246 0.733808025546023 MAEL/ADCY3/MFGE8/CD9/PLCB1/STX2/ASH1L/FNDC3A 8 GO:0061013 regulation of mRNA catabolic process 7/803 166/18722 0.572311661643937 0.734125532533231 PRKCA/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/PUM2 7 GO:0006368 transcription elongation from RNA polymerase II promoter 3/803 69/18722 0.572839763575202 0.734236262515671 ZMYND11/ZMIZ1/RTF1 3 GO:0007004 telomere maintenance via telomerase 3/803 69/18722 0.572839763575202 0.734236262515671 TERF1/NEK7/ATM 3 GO:1901224 positive regulation of NIK/NF-kappaB signaling 3/803 69/18722 0.572839763575202 0.734236262515671 NFAT5/AGO3/ACTN4 3 GO:0042113 B cell activation 14/803 334/18722 0.573844982758814 0.735335667960794 VCAM1/LGALS1/CD81/PIK3R1/ZFP36L2/ZFP36L1/BST2/ITGB1/NOTCH2/ABL1/KLF6/SP3/ATM/NDFIP1 14 GO:0006413 translational initiation 5/803 118/18722 0.574772236277153 0.736334627460915 EIF4EBP1/EIF4G3/EIF4A2/EIF4EBP2/HSPB1 5 GO:0140014 mitotic nuclear division 12/803 287/18722 0.57763281894924 0.737991001358694 PDGFRB/HOXA13/BMP4/FLNA/IGF2/CCDC8/EPS8/MAP9/PDS5B/ATRX/EML4/ATM 12 GO:0055088 lipid homeostasis 7/803 167/18722 0.57870775597342 0.737991001358694 RBP1/APOE/CES1/RTN4/PRKAA1/NPC2/ABCA5 7 GO:0006865 amino acid transport 6/803 143/18722 0.580077167834428 0.737991001358694 SLC16A10/GJA1/SERINC3/ITGB1/SLC38A2/SERINC5 6 GO:0031023 microtubule organizing center organization 6/803 143/18722 0.580077167834428 0.737991001358694 PKD2/ROCK2/MPDZ/NIN/CEP44/MAP9 6 GO:0032309 icosanoid secretion 2/803 45/18722 0.580756715717389 0.737991001358694 PLA2G2A/PLA2R1 2 GO:0035305 negative regulation of dephosphorylation 2/803 45/18722 0.580756715717389 0.737991001358694 MFHAS1/ROCK2 2 GO:0035384 thioester biosynthetic process 2/803 45/18722 0.580756715717389 0.737991001358694 ELOVL2/PDK4 2 GO:0042551 neuron maturation 2/803 45/18722 0.580756715717389 0.737991001358694 EDNRB/NRCAM 2 GO:0046189 phenol-containing compound biosynthetic process 2/803 45/18722 0.580756715717389 0.737991001358694 HAND2/ZEB2 2 GO:0048538 thymus development 2/803 45/18722 0.580756715717389 0.737991001358694 HAND2/ABL1 2 GO:0051180 vitamin transport 2/803 45/18722 0.580756715717389 0.737991001358694 SLC2A10/SLC19A3 2 GO:0071616 acyl-CoA biosynthetic process 2/803 45/18722 0.580756715717389 0.737991001358694 ELOVL2/PDK4 2 GO:1901985 positive regulation of protein acetylation 2/803 45/18722 0.580756715717389 0.737991001358694 TAOK1/PRKAA1 2 GO:2000273 positive regulation of signaling receptor activity 2/803 45/18722 0.580756715717389 0.737991001358694 ITGB1/IFNGR2 2 GO:0010906 regulation of glucose metabolic process 5/803 119/18722 0.582319638090487 0.737991001358694 ENPP1/NNMT/IGF2/IRS1/PDK4 5 GO:0015833 peptide transport 11/803 264/18722 0.58250801929287 0.737991001358694 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 11 GO:0003407 neural retina development 3/803 70/18722 0.582672014902262 0.737991001358694 THY1/PROM1/HIPK1 3 GO:0022412 cellular process involved in reproduction in multicellular organism 16/803 384/18722 0.583664083155182 0.737991001358694 SLIT2/PDE3A/SLIT3/MAEL/BMP4/CD9/HSPA2/SMAD5/MDK/ITGB1/CDC25B/PRKAR1A/FNDC3A/FOXO3/ZMIZ1/SOS1 16 GO:0000272 polysaccharide catabolic process 1/803 20/18722 0.584057860281068 0.737991001358694 RB1CC1 1 GO:0002577 regulation of antigen processing and presentation 1/803 20/18722 0.584057860281068 0.737991001358694 THBS1 1 GO:0003159 morphogenesis of an endothelium 1/803 20/18722 0.584057860281068 0.737991001358694 BMP4 1 GO:0006837 serotonin transport 1/803 20/18722 0.584057860281068 0.737991001358694 SLC22A3 1 GO:0006896 Golgi to vacuole transport 1/803 20/18722 0.584057860281068 0.737991001358694 SORT1 1 GO:0009713 catechol-containing compound biosynthetic process 1/803 20/18722 0.584057860281068 0.737991001358694 HAND2 1 GO:0010523 negative regulation of calcium ion transport into cytosol 1/803 20/18722 0.584057860281068 0.737991001358694 PKD2 1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1/803 20/18722 0.584057860281068 0.737991001358694 SPRED1 1 GO:0010893 positive regulation of steroid biosynthetic process 1/803 20/18722 0.584057860281068 0.737991001358694 PRKAA1 1 GO:0014047 glutamate secretion 1/803 20/18722 0.584057860281068 0.737991001358694 GJA1 1 GO:0017121 plasma membrane phospholipid scrambling 1/803 20/18722 0.584057860281068 0.737991001358694 PLSCR4 1 GO:0032211 negative regulation of telomere maintenance via telomerase 1/803 20/18722 0.584057860281068 0.737991001358694 TERF1 1 GO:0034104 negative regulation of tissue remodeling 1/803 20/18722 0.584057860281068 0.737991001358694 GPR137B 1 GO:0039535 regulation of RIG-I signaling pathway 1/803 20/18722 0.584057860281068 0.737991001358694 PUM2 1 GO:0042359 vitamin D metabolic process 1/803 20/18722 0.584057860281068 0.737991001358694 SNAI2 1 GO:0042423 catecholamine biosynthetic process 1/803 20/18722 0.584057860281068 0.737991001358694 HAND2 1 GO:0043046 DNA methylation involved in gamete generation 1/803 20/18722 0.584057860281068 0.737991001358694 MAEL 1 GO:0043651 linoleic acid metabolic process 1/803 20/18722 0.584057860281068 0.737991001358694 ELOVL2 1 GO:0043984 histone H4-K16 acetylation 1/803 20/18722 0.584057860281068 0.737991001358694 KMT2A 1 GO:0045063 T-helper 1 cell differentiation 1/803 20/18722 0.584057860281068 0.737991001358694 TMEM98 1 GO:0046485 ether lipid metabolic process 1/803 20/18722 0.584057860281068 0.737991001358694 LPCAT2 1 GO:0046931 pore complex assembly 1/803 20/18722 0.584057860281068 0.737991001358694 RTN4 1 GO:0048670 regulation of collateral sprouting 1/803 20/18722 0.584057860281068 0.737991001358694 LRP1 1 GO:0060252 positive regulation of glial cell proliferation 1/803 20/18722 0.584057860281068 0.737991001358694 TSPO 1 GO:0061154 endothelial tube morphogenesis 1/803 20/18722 0.584057860281068 0.737991001358694 BMP4 1 GO:0070166 enamel mineralization 1/803 20/18722 0.584057860281068 0.737991001358694 FAM20C 1 GO:0071243 cellular response to arsenic-containing substance 1/803 20/18722 0.584057860281068 0.737991001358694 SLC38A2 1 GO:0071625 vocalization behavior 1/803 20/18722 0.584057860281068 0.737991001358694 EXT1 1 GO:0072087 renal vesicle development 1/803 20/18722 0.584057860281068 0.737991001358694 BMP4 1 GO:0140632 inflammasome complex assembly 1/803 20/18722 0.584057860281068 0.737991001358694 CD36 1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/803 20/18722 0.584057860281068 0.737991001358694 HSPB1 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/803 20/18722 0.584057860281068 0.737991001358694 CREB3L1 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/803 20/18722 0.584057860281068 0.737991001358694 HGF 1 GO:1904263 positive regulation of TORC1 signaling 1/803 20/18722 0.584057860281068 0.737991001358694 GPR137B 1 GO:1990182 exosomal secretion 1/803 20/18722 0.584057860281068 0.737991001358694 SDC1 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/803 20/18722 0.584057860281068 0.737991001358694 TWIST1 1 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/803 168/18722 0.585057599211318 0.739066934296335 IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F/NDFIP1 7 GO:0002532 production of molecular mediator involved in inflammatory response 4/803 95/18722 0.586007175004888 0.739891561046941 APOD/CD36/PLD3/STAT3 4 GO:0036473 cell death in response to oxidative stress 4/803 95/18722 0.586007175004888 0.739891561046941 HGF/GATA4/FOXO3/HSPB1 4 GO:0006304 DNA modification 5/803 120/18722 0.589794541495541 0.744484957948549 MAEL/KMT2A/ATRX/KMT2E/USP9X 5 GO:0008344 adult locomotory behavior 3/803 71/18722 0.592359333206203 0.74657909825112 CCND2/PREX2/EPS8 3 GO:0006984 ER-nucleus signaling pathway 2/803 46/18722 0.592801173280422 0.74657909825112 AMFR/MBTPS1 2 GO:0007019 microtubule depolymerization 2/803 46/18722 0.592801173280422 0.74657909825112 MAP1B/TAOK1 2 GO:0031057 negative regulation of histone modification 2/803 46/18722 0.592801173280422 0.74657909825112 TWIST1/SKI 2 GO:0031648 protein destabilization 2/803 46/18722 0.592801173280422 0.74657909825112 PRNP/GSN 2 GO:0034198 cellular response to amino acid starvation 2/803 46/18722 0.592801173280422 0.74657909825112 SESN3/SLC38A2 2 GO:0035094 response to nicotine 2/803 46/18722 0.592801173280422 0.74657909825112 VCAM1/B2M 2 GO:0043300 regulation of leukocyte degranulation 2/803 46/18722 0.592801173280422 0.74657909825112 HLA-F/FER 2 GO:0044818 mitotic G2/M transition checkpoint 2/803 46/18722 0.592801173280422 0.74657909825112 TAOK1/ATM 2 GO:0043524 negative regulation of neuron apoptotic process 6/803 145/18722 0.593706789916331 0.747530821849199 APOE/ANGPT1/MDK/LRP1/AXL/GCLM 6 GO:0042472 inner ear morphogenesis 4/803 96/18722 0.594328235300754 0.747935532864603 CTHRC1/COL11A1/PTK7/CEP290 4 GO:0042632 cholesterol homeostasis 4/803 96/18722 0.594328235300754 0.747935532864603 APOE/CES1/NPC2/ABCA5 4 GO:0043487 regulation of RNA stability 7/803 170/18722 0.597614262899696 0.750664866746251 PRKCA/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/PUM2 7 GO:0045580 regulation of T cell differentiation 6/803 146/18722 0.600433434605549 0.750664866746251 BMP4/MDK/TGFBR2/ABL1/ZMIZ1/SOS1 6 GO:0030073 insulin secretion 8/803 195/18722 0.601461703550237 0.750664866746251 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/CLOCK 8 GO:0002534 cytokine production involved in inflammatory response 3/803 72/18722 0.60189987977681 0.750664866746251 APOD/PLD3/STAT3 3 GO:0050709 negative regulation of protein secretion 3/803 72/18722 0.60189987977681 0.750664866746251 APOE/IRS1/MAP4K4 3 GO:1900015 regulation of cytokine production involved in inflammatory response 3/803 72/18722 0.60189987977681 0.750664866746251 APOD/PLD3/STAT3 3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 1/803 21/18722 0.601916995036405 0.750664866746251 COX7A1 1 GO:0006353 DNA-templated transcription, termination 1/803 21/18722 0.601916995036405 0.750664866746251 SETX 1 GO:0007063 regulation of sister chromatid cohesion 1/803 21/18722 0.601916995036405 0.750664866746251 ATRX 1 GO:0008090 retrograde axonal transport 1/803 21/18722 0.601916995036405 0.750664866746251 DST 1 GO:0009067 aspartate family amino acid biosynthetic process 1/803 21/18722 0.601916995036405 0.750664866746251 PLOD2 1 GO:0019985 translesion synthesis 1/803 21/18722 0.601916995036405 0.750664866746251 REV3L 1 GO:0023019 signal transduction involved in regulation of gene expression 1/803 21/18722 0.601916995036405 0.750664866746251 PDGFRA 1 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 1/803 21/18722 0.601916995036405 0.750664866746251 STX2 1 GO:0032303 regulation of icosanoid secretion 1/803 21/18722 0.601916995036405 0.750664866746251 PLA2R1 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/803 21/18722 0.601916995036405 0.750664866746251 PIEZO1 1 GO:0034471 ncRNA 5'-end processing 1/803 21/18722 0.601916995036405 0.750664866746251 RPP25 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/803 21/18722 0.601916995036405 0.750664866746251 ABL1 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/803 21/18722 0.601916995036405 0.750664866746251 STAT3 1 GO:0044241 lipid digestion 1/803 21/18722 0.601916995036405 0.750664866746251 CD36 1 GO:0048199 vesicle targeting, to, from or within Golgi 1/803 21/18722 0.601916995036405 0.750664866746251 SAR1A 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/803 21/18722 0.601916995036405 0.750664866746251 MDK 1 GO:0050802 circadian sleep/wake cycle, sleep 1/803 21/18722 0.601916995036405 0.750664866746251 PTGDS 1 GO:0050849 negative regulation of calcium-mediated signaling 1/803 21/18722 0.601916995036405 0.750664866746251 PRNP 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/803 21/18722 0.601916995036405 0.750664866746251 AKAP12 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/803 21/18722 0.601916995036405 0.750664866746251 AKAP12 1 GO:0090141 positive regulation of mitochondrial fission 1/803 21/18722 0.601916995036405 0.750664866746251 DCN 1 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 1/803 21/18722 0.601916995036405 0.750664866746251 BMP4 1 GO:0097734 extracellular exosome biogenesis 1/803 21/18722 0.601916995036405 0.750664866746251 SDC1 1 GO:0098856 intestinal lipid absorption 1/803 21/18722 0.601916995036405 0.750664866746251 CD36 1 GO:0099500 vesicle fusion to plasma membrane 1/803 21/18722 0.601916995036405 0.750664866746251 STX2 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/803 21/18722 0.601916995036405 0.750664866746251 STAT3 1 GO:1903429 regulation of cell maturation 1/803 21/18722 0.601916995036405 0.750664866746251 EDNRB 1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 1/803 21/18722 0.601916995036405 0.750664866746251 TJP1 1 GO:2000774 positive regulation of cellular senescence 1/803 21/18722 0.601916995036405 0.750664866746251 B2M 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/803 21/18722 0.601916995036405 0.750664866746251 DDX17 1 GO:0055092 sterol homeostasis 4/803 97/18722 0.602549253684042 0.751174170593843 APOE/CES1/NPC2/ABCA5 4 GO:0048469 cell maturation 7/803 171/18722 0.603819063004131 0.751174170593843 PDE3A/EDNRB/NRCAM/AXL/EPAS1/CDC25B/FOXO3 7 GO:0019730 antimicrobial humoral response 5/803 122/18722 0.604521079750962 0.751174170593843 CXCL14/RARRES2/SPON2/GATA6/HLA-A 5 GO:0031109 microtubule polymerization or depolymerization 5/803 122/18722 0.604521079750962 0.751174170593843 MAP1B/CRYAB/NIN/ABL1/TAOK1 5 GO:0072329 monocarboxylic acid catabolic process 5/803 122/18722 0.604521079750962 0.751174170593843 CRABP1/BDH2/IRS1/TWIST1/LPIN1 5 GO:1990266 neutrophil migration 5/803 122/18722 0.604521079750962 0.751174170593843 SLIT2/ITGA1/IL1R1/MDK/DPP4 5 GO:0001774 microglial cell activation 2/803 47/18722 0.604585227956898 0.751174170593843 CLU/IFNGR2 2 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 2/803 47/18722 0.604585227956898 0.751174170593843 ECE1/TPM1 2 GO:0006998 nuclear envelope organization 2/803 47/18722 0.604585227956898 0.751174170593843 PRKCA/LPIN1 2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 2/803 47/18722 0.604585227956898 0.751174170593843 GAS6/HIPK1 2 GO:0032008 positive regulation of TOR signaling 2/803 47/18722 0.604585227956898 0.751174170593843 GAS6/GPR137B 2 GO:0032369 negative regulation of lipid transport 2/803 47/18722 0.604585227956898 0.751174170593843 THBS1/PLA2R1 2 GO:0035315 hair cell differentiation 2/803 47/18722 0.604585227956898 0.751174170593843 PITX2/JAG1 2 GO:0045581 negative regulation of T cell differentiation 2/803 47/18722 0.604585227956898 0.751174170593843 BMP4/MDK 2 GO:0097300 programmed necrotic cell death 2/803 47/18722 0.604585227956898 0.751174170593843 NUPR1/IPMK 2 GO:0006006 glucose metabolic process 8/803 196/18722 0.607246904649229 0.754293240304199 ENPP1/APOD/NNMT/IGF2/IRS1/PDK4/H6PD/PRKAA1 8 GO:0051656 establishment of organelle localization 16/803 390/18722 0.608704265053865 0.755915184447963 PTGDS/MAP1B/MYO1B/GJA1/SPRY1/MYO1E/ITGB1/SAR1A/ARHGAP21/EML4/ARMCX3/WASL/FER/MYO1C/TERF1/ACTN4 16 GO:0002221 pattern recognition receptor signaling pathway 7/803 172/18722 0.609973570601066 0.757302844376722 CD36/MFHAS1/TIFA/RTN4/PUM2/PJA2/TSPAN6 7 GO:0032456 endocytic recycling 3/803 73/18722 0.611292074684926 0.758184647855482 EHD2/ANKRD50/ACAP2 3 GO:0043299 leukocyte degranulation 3/803 73/18722 0.611292074684926 0.758184647855482 PTGDS/HLA-F/FER 3 GO:0051298 centrosome duplication 3/803 73/18722 0.611292074684926 0.758184647855482 PKD2/ROCK2/CEP44 3 GO:0051865 protein autoubiquitination 3/803 73/18722 0.611292074684926 0.758184647855482 LTN1/AMFR/HECTD1 3 GO:0016570 histone modification 19/803 463/18722 0.612038564259266 0.75892173126006 NNMT/PRDM6/PRKCA/IGF2/KAT6B/CAMK2D/TWIST1/KMT2A/ASH1L/TBL1XR1/ATRX/SKI/PRKAA1/MIER1/KMT2E/RTF1/ATM/CLOCK/NCOA1 19 GO:0000910 cytokinesis 7/803 173/18722 0.616076888236461 0.760006162117326 SPTBN1/SON/ROCK2/CDC25B/MAP9/PLEC/KLHL9 7 GO:0043303 mast cell degranulation 2/803 48/18722 0.616109033421661 0.760006162117326 PTGDS/FER 2 GO:0045839 negative regulation of mitotic nuclear division 2/803 48/18722 0.616109033421661 0.760006162117326 BMP4/ATM 2 GO:0072521 purine-containing compound metabolic process 17/803 416/18722 0.616419055156627 0.760006162117326 ENPP1/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 17 GO:0000045 autophagosome assembly 4/803 99/18722 0.618685238486122 0.760006162117326 SYNPO2/RAB23/NUPR1/RB1CC1 4 GO:0021549 cerebellum development 4/803 99/18722 0.618685238486122 0.760006162117326 SERPINE2/MDK/ABL1/NCOA1 4 GO:0051153 regulation of striated muscle cell differentiation 4/803 99/18722 0.618685238486122 0.760006162117326 BMP4/EFNB2/PIEZO1/FRS2 4 GO:0048167 regulation of synaptic plasticity 8/803 198/18722 0.618686984869619 0.760006162117326 MAP1B/SERPINE2/APOE/PTEN/PRNP/ABL1/NPTN/EIF4EBP2 8 GO:0001909 leukocyte mediated cytotoxicity 5/803 124/18722 0.618941226075103 0.760006162117326 HLA-B/HLA-A/B2M/HLA-F/SERPINB9 5 GO:0009132 nucleoside diphosphate metabolic process 5/803 124/18722 0.618941226075103 0.760006162117326 CASK/NUPR1/MAGI3/STAT3/PRKAA1 5 GO:0006662 glycerol ether metabolic process 1/803 22/18722 0.619010233525564 0.760006162117326 LPCAT2 1 GO:0006907 pinocytosis 1/803 22/18722 0.619010233525564 0.760006162117326 AXL 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/803 22/18722 0.619010233525564 0.760006162117326 CD9 1 GO:0010310 regulation of hydrogen peroxide metabolic process 1/803 22/18722 0.619010233525564 0.760006162117326 STAT3 1 GO:0010866 regulation of triglyceride biosynthetic process 1/803 22/18722 0.619010233525564 0.760006162117326 LPIN1 1 GO:0016137 glycoside metabolic process 1/803 22/18722 0.619010233525564 0.760006162117326 FUCA2 1 GO:0021904 dorsal/ventral neural tube patterning 1/803 22/18722 0.619010233525564 0.760006162117326 BMP4 1 GO:0022616 DNA strand elongation 1/803 22/18722 0.619010233525564 0.760006162117326 NUCKS1 1 GO:0031281 positive regulation of cyclase activity 1/803 22/18722 0.619010233525564 0.760006162117326 TIMP2 1 GO:0032069 regulation of nuclease activity 1/803 22/18722 0.619010233525564 0.760006162117326 TERF1 1 GO:0032700 negative regulation of interleukin-17 production 1/803 22/18722 0.619010233525564 0.760006162117326 PRNP 1 GO:0034755 iron ion transmembrane transport 1/803 22/18722 0.619010233525564 0.760006162117326 SLC40A1 1 GO:0035268 protein mannosylation 1/803 22/18722 0.619010233525564 0.760006162117326 DPY19L4 1 GO:0035561 regulation of chromatin binding 1/803 22/18722 0.619010233525564 0.760006162117326 ZNF618 1 GO:0035809 regulation of urine volume 1/803 22/18722 0.619010233525564 0.760006162117326 EDNRB 1 GO:0036120 cellular response to platelet-derived growth factor stimulus 1/803 22/18722 0.619010233525564 0.760006162117326 PDGFRB 1 GO:0042749 regulation of circadian sleep/wake cycle 1/803 22/18722 0.619010233525564 0.760006162117326 PTGDS 1 GO:0044346 fibroblast apoptotic process 1/803 22/18722 0.619010233525564 0.760006162117326 GAS6 1 GO:0046058 cAMP metabolic process 1/803 22/18722 0.619010233525564 0.760006162117326 ADCY3 1 GO:0048169 regulation of long-term neuronal synaptic plasticity 1/803 22/18722 0.619010233525564 0.760006162117326 NPTN 1 GO:0051151 negative regulation of smooth muscle cell differentiation 1/803 22/18722 0.619010233525564 0.760006162117326 PRDM6 1 GO:0051412 response to corticosterone 1/803 22/18722 0.619010233525564 0.760006162117326 FOXO3 1 GO:0060444 branching involved in mammary gland duct morphogenesis 1/803 22/18722 0.619010233525564 0.760006162117326 CSF1 1 GO:0061042 vascular wound healing 1/803 22/18722 0.619010233525564 0.760006162117326 SMOC2 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/803 22/18722 0.619010233525564 0.760006162117326 SLC8A1 1 GO:0097164 ammonium ion metabolic process 1/803 22/18722 0.619010233525564 0.760006162117326 SLC22A3 1 GO:1900120 regulation of receptor binding 1/803 22/18722 0.619010233525564 0.760006162117326 B2M 1 GO:1901032 negative regulation of response to reactive oxygen species 1/803 22/18722 0.619010233525564 0.760006162117326 HGF 1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 1/803 22/18722 0.619010233525564 0.760006162117326 SMAD5 1 GO:2000193 positive regulation of fatty acid transport 1/803 22/18722 0.619010233525564 0.760006162117326 PLA2R1 1 GO:1905039 carboxylic acid transmembrane transport 6/803 149/18722 0.620247318104578 0.761315315279765 SLC16A10/CD36/THBS1/SLC16A7/ITGB1/SLC38A2 6 GO:0002437 inflammatory response to antigenic stimulus 3/803 74/18722 0.620534585097666 0.761315315279765 CD81/EXT1/NOTCH2 3 GO:0006635 fatty acid beta-oxidation 3/803 74/18722 0.620534585097666 0.761315315279765 BDH2/IRS1/TWIST1 3 GO:0006626 protein targeting to mitochondrion 4/803 100/18722 0.62659759155865 0.766874924841299 TSPO/NPEPPS/PRKAA1/BNIP3L 4 GO:0006641 triglyceride metabolic process 4/803 100/18722 0.62659759155865 0.766874924841299 TNXB/APOE/LPGAT1/LPIN1 4 GO:0009062 fatty acid catabolic process 4/803 100/18722 0.62659759155865 0.766874924841299 BDH2/IRS1/TWIST1/LPIN1 4 GO:0051588 regulation of neurotransmitter transport 4/803 100/18722 0.62659759155865 0.766874924841299 CASK/ITGB1/PREPL/MCTP2 4 GO:1903825 organic acid transmembrane transport 6/803 150/18722 0.626726570486152 0.766874924841299 SLC16A10/CD36/THBS1/SLC16A7/ITGB1/SLC38A2 6 GO:0000959 mitochondrial RNA metabolic process 2/803 49/18722 0.627373208669807 0.766874924841299 FOXO3/PRKAA1 2 GO:0002279 mast cell activation involved in immune response 2/803 49/18722 0.627373208669807 0.766874924841299 PTGDS/FER 2 GO:0006953 acute-phase response 2/803 49/18722 0.627373208669807 0.766874924841299 EDNRB/STAT3 2 GO:0008206 bile acid metabolic process 2/803 49/18722 0.627373208669807 0.766874924841299 CES1/OSBPL1A 2 GO:0021695 cerebellar cortex development 2/803 49/18722 0.627373208669807 0.766874924841299 SERPINE2/MDK 2 GO:0042304 regulation of fatty acid biosynthetic process 2/803 49/18722 0.627373208669807 0.766874924841299 PDK4/LPGAT1 2 GO:0048168 regulation of neuronal synaptic plasticity 2/803 49/18722 0.627373208669807 0.766874924841299 APOE/NPTN 2 GO:0050832 defense response to fungus 2/803 49/18722 0.627373208669807 0.766874924841299 RARRES2/SPON2 2 GO:0086009 membrane repolarization 2/803 49/18722 0.627373208669807 0.766874924841299 FLNA/ATP1B1 2 GO:1990573 potassium ion import across plasma membrane 2/803 49/18722 0.627373208669807 0.766874924841299 ATP1B1/WNK1 2 GO:0006278 RNA-dependent DNA biosynthetic process 3/803 75/18722 0.629626313814961 0.769251850203723 TERF1/NEK7/ATM 3 GO:0036465 synaptic vesicle recycling 3/803 75/18722 0.629626313814961 0.769251850203723 STON1/CANX/ITSN1 3 GO:0006576 cellular biogenic amine metabolic process 4/803 101/18722 0.634404667592854 0.770399867575852 HAND2/NNMT/SLC22A3/EPAS1 4 GO:0048024 regulation of mRNA splicing, via spliceosome 4/803 101/18722 0.634404667592854 0.770399867575852 SON/CELF2/DDX17/MBNL2 4 GO:0050830 defense response to Gram-positive bacterium 4/803 101/18722 0.634404667592854 0.770399867575852 RARRES2/PLA2G2A/CD36/HLA-A 4 GO:0000966 RNA 5'-end processing 1/803 23/18722 0.635370382321231 0.770399867575852 RPP25 1 GO:0001919 regulation of receptor recycling 1/803 23/18722 0.635370382321231 0.770399867575852 ECE1 1 GO:0002363 alpha-beta T cell lineage commitment 1/803 23/18722 0.635370382321231 0.770399867575852 STAT3 1 GO:0006541 glutamine metabolic process 1/803 23/18722 0.635370382321231 0.770399867575852 GLS 1 GO:0007130 synaptonemal complex assembly 1/803 23/18722 0.635370382321231 0.770399867575852 P3H4 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/803 23/18722 0.635370382321231 0.770399867575852 GAS6 1 GO:0010888 negative regulation of lipid storage 1/803 23/18722 0.635370382321231 0.770399867575852 CES1 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/803 23/18722 0.635370382321231 0.770399867575852 CLDN1 1 GO:0021871 forebrain regionalization 1/803 23/18722 0.635370382321231 0.770399867575852 BMP4 1 GO:0034105 positive regulation of tissue remodeling 1/803 23/18722 0.635370382321231 0.770399867575852 ROCK2 1 GO:0040019 positive regulation of embryonic development 1/803 23/18722 0.635370382321231 0.770399867575852 PLCB1 1 GO:0042438 melanin biosynthetic process 1/803 23/18722 0.635370382321231 0.770399867575852 ZEB2 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/803 23/18722 0.635370382321231 0.770399867575852 STAT3 1 GO:0043931 ossification involved in bone maturation 1/803 23/18722 0.635370382321231 0.770399867575852 EXT1 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/803 23/18722 0.635370382321231 0.770399867575852 LPGAT1 1 GO:0045724 positive regulation of cilium assembly 1/803 23/18722 0.635370382321231 0.770399867575852 CCDC88A 1 GO:0051131 chaperone-mediated protein complex assembly 1/803 23/18722 0.635370382321231 0.770399867575852 CLU 1 GO:0051349 positive regulation of lyase activity 1/803 23/18722 0.635370382321231 0.770399867575852 TIMP2 1 GO:0051457 maintenance of protein location in nucleus 1/803 23/18722 0.635370382321231 0.770399867575852 SYNE1 1 GO:0051590 positive regulation of neurotransmitter transport 1/803 23/18722 0.635370382321231 0.770399867575852 ITGB1 1 GO:0060547 negative regulation of necrotic cell death 1/803 23/18722 0.635370382321231 0.770399867575852 NUPR1 1 GO:0090335 regulation of brown fat cell differentiation 1/803 23/18722 0.635370382321231 0.770399867575852 METRNL 1 GO:0099590 neurotransmitter receptor internalization 1/803 23/18722 0.635370382321231 0.770399867575852 AP2B1 1 GO:0140112 extracellular vesicle biogenesis 1/803 23/18722 0.635370382321231 0.770399867575852 SDC1 1 GO:1900273 positive regulation of long-term synaptic potentiation 1/803 23/18722 0.635370382321231 0.770399867575852 NPTN 1 GO:1903306 negative regulation of regulated secretory pathway 1/803 23/18722 0.635370382321231 0.770399867575852 HLA-F 1 GO:1904666 regulation of ubiquitin protein ligase activity 1/803 23/18722 0.635370382321231 0.770399867575852 PTEN 1 GO:0006473 protein acetylation 8/803 201/18722 0.635510360076109 0.770399867575852 KAT6B/TWIST1/NUPR1/KMT2A/TAOK1/PRKAA1/CLOCK/NCOA1 8 GO:0051054 positive regulation of DNA metabolic process 8/803 201/18722 0.635510360076109 0.770399867575852 HGF/PDGFRB/SMOC2/KLF4/ATRX/NEK7/ATM/USP9X 8 GO:0002366 leukocyte activation involved in immune response 11/803 275/18722 0.636624744374896 0.77156319286661 PTGDS/TMEM98/LGALS1/CD81/MDK/NOTCH2/ABL1/HLA-F/STAT3/FER/NDFIP1 11 GO:0007140 male meiotic nuclear division 2/803 50/18722 0.638378797913756 0.772749863170184 MAEL/HSPA2 2 GO:0046460 neutral lipid biosynthetic process 2/803 50/18722 0.638378797913756 0.772749863170184 LPGAT1/LPIN1 2 GO:0046463 acylglycerol biosynthetic process 2/803 50/18722 0.638378797913756 0.772749863170184 LPGAT1/LPIN1 2 GO:0051646 mitochondrion localization 2/803 50/18722 0.638378797913756 0.772749863170184 MAP1B/ARMCX3 2 GO:0090102 cochlea development 2/803 50/18722 0.638378797913756 0.772749863170184 CTHRC1/PTK7 2 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 3/803 76/18722 0.638566388042859 0.772789323005266 NUPR1/HIPK1/IFI16 3 GO:0051092 positive regulation of NF-kappaB transcription factor activity 6/803 152/18722 0.639491596698167 0.773721208720471 CD36/MTDH/CLU/STAT3/FER/CLOCK 6 GO:0051648 vesicle localization 7/803 177/18722 0.639961850774802 0.774102326046376 MYO1B/MYO1E/PTEN/SAR1A/WASL/MYO1C/ACTN4 7 GO:0016051 carbohydrate biosynthetic process 8/803 202/18722 0.64102566703432 0.775201061322609 ENPP1/NNMT/CSGALNACT1/CSGALNACT2/IGF2/IRS1/EXT1/CLTC 8 GO:0034308 primary alcohol metabolic process 4/803 102/18722 0.642105490680041 0.776318617005501 BMP5/DKK3/RDH10/H6PD 4 GO:0042886 amide transport 12/803 301/18722 0.643562956208772 0.777892096886531 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/PLTP/SIDT2/MAP4K4/ITSN1/CLOCK 12 GO:0007338 single fertilization 6/803 153/18722 0.64577577003842 0.779920667547916 ADCY3/MFGE8/CD9/PLCB1/STX2/ASH1L 6 GO:0120254 olefinic compound metabolic process 6/803 153/18722 0.64577577003842 0.779920667547916 PTGDS/BMP5/ELOVL2/DKK3/RDH10/H6PD 6 GO:0032612 interleukin-1 production 5/803 128/18722 0.646826957551321 0.779920667547916 GAS6/CD36/STAT3/IFI16/HSPB1 5 GO:0032652 regulation of interleukin-1 production 5/803 128/18722 0.646826957551321 0.779920667547916 GAS6/CD36/STAT3/IFI16/HSPB1 5 GO:0000380 alternative mRNA splicing, via spliceosome 3/803 77/18722 0.647354148416798 0.779920667547916 CELF2/DDX17/MBNL2 3 GO:0032418 lysosome localization 3/803 77/18722 0.647354148416798 0.779920667547916 PTGDS/TMEM106B/FER 3 GO:0032873 negative regulation of stress-activated MAPK cascade 2/803 51/18722 0.64912723305721 0.779920667547916 HIPK3/ZMYND11 2 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 2/803 51/18722 0.64912723305721 0.779920667547916 HIPK3/ZMYND11 2 GO:0019233 sensory perception of pain 4/803 103/18722 0.649699209587782 0.779920667547916 NDN/SPX/EDNRB/TMEM120A 4 GO:0030593 neutrophil chemotaxis 4/803 103/18722 0.649699209587782 0.779920667547916 SLIT2/ITGA1/MDK/DPP4 4 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 4/803 103/18722 0.649699209587782 0.779920667547916 PTPRD/PRLR/SOCS2/SOCS3 4 GO:0090277 positive regulation of peptide hormone secretion 4/803 103/18722 0.649699209587782 0.779920667547916 CAMK2N1/GJA1/LRP1/ITSN1 4 GO:1905037 autophagosome organization 4/803 103/18722 0.649699209587782 0.779920667547916 SYNPO2/RAB23/NUPR1/RB1CC1 4 GO:0006401 RNA catabolic process 11/803 278/18722 0.650728885961372 0.779920667547916 PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 11 GO:0031349 positive regulation of defense response 11/803 278/18722 0.650728885961372 0.779920667547916 PLA2G2A/OSMR/GJA1/IL6ST/CD81/MDK/NUPR1/TNFRSF1A/HLA-F/IFI16/CLOCK 11 GO:0001783 B cell apoptotic process 1/803 24/18722 0.651028844431293 0.779920667547916 PTEN 1 GO:0002021 response to dietary excess 1/803 24/18722 0.651028844431293 0.779920667547916 APOE 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/803 24/18722 0.651028844431293 0.779920667547916 EXT1 1 GO:0006582 melanin metabolic process 1/803 24/18722 0.651028844431293 0.779920667547916 ZEB2 1 GO:0007035 vacuolar acidification 1/803 24/18722 0.651028844431293 0.779920667547916 TMEM106B 1 GO:0010226 response to lithium ion 1/803 24/18722 0.651028844431293 0.779920667547916 IGFBP2 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/803 24/18722 0.651028844431293 0.779920667547916 ZDHHC21 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/803 24/18722 0.651028844431293 0.779920667547916 ZDHHC21 1 GO:0022410 circadian sleep/wake cycle process 1/803 24/18722 0.651028844431293 0.779920667547916 PTGDS 1 GO:0030878 thyroid gland development 1/803 24/18722 0.651028844431293 0.779920667547916 THRA 1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 1/803 24/18722 0.651028844431293 0.779920667547916 CREB3L1 1 GO:0043302 positive regulation of leukocyte degranulation 1/803 24/18722 0.651028844431293 0.779920667547916 HLA-F 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/803 24/18722 0.651028844431293 0.779920667547916 APOE 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/803 24/18722 0.651028844431293 0.779920667547916 THRA 1 GO:0051156 glucose 6-phosphate metabolic process 1/803 24/18722 0.651028844431293 0.779920667547916 H6PD 1 GO:0051570 regulation of histone H3-K9 methylation 1/803 24/18722 0.651028844431293 0.779920667547916 ATRX 1 GO:0051647 nucleus localization 1/803 24/18722 0.651028844431293 0.779920667547916 BIN1 1 GO:0071294 cellular response to zinc ion 1/803 24/18722 0.651028844431293 0.779920667547916 TSPO 1 GO:0072530 purine-containing compound transmembrane transport 1/803 24/18722 0.651028844431293 0.779920667547916 SLC22A3 1 GO:0090023 positive regulation of neutrophil chemotaxis 1/803 24/18722 0.651028844431293 0.779920667547916 MDK 1 GO:0090343 positive regulation of cell aging 1/803 24/18722 0.651028844431293 0.779920667547916 B2M 1 GO:1901984 negative regulation of protein acetylation 1/803 24/18722 0.651028844431293 0.779920667547916 TWIST1 1 GO:0007605 sensory perception of sound 6/803 154/18722 0.651993411281618 0.780888577624345 COL1A1/COL11A1/SNAI2/SCARB2/CCDC50/NAV2 6 GO:0071695 anatomical structure maturation 9/803 229/18722 0.652752381977182 0.781609840667202 MMP2/PDE3A/EDNRB/NRCAM/EXT1/AXL/EPAS1/CDC25B/FOXO3 9 GO:0032024 positive regulation of insulin secretion 3/803 78/18722 0.655989138285908 0.785296961222938 CAMK2N1/GJA1/LRP1 3 GO:0046634 regulation of alpha-beta T cell activation 4/803 104/18722 0.657185093526985 0.786489253512588 TWSG1/HLA-A/CD81/TGFBR2 4 GO:0015698 inorganic anion transport 7/803 180/18722 0.657300585516838 0.786489253512588 ENPP1/FXYD1/CLCN5/APOL1/TSPO/PRNP/ANO10 7 GO:0010970 transport along microtubule 6/803 155/18722 0.658143860705345 0.787309330488688 MAP1B/DST/PURA/ARHGAP21/ARMCX3/HSPB1 6 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 2/803 52/18722 0.659620298599163 0.78850798581046 COPZ2/PLPP3 2 GO:0007129 homologous chromosome pairing at meiosis 2/803 52/18722 0.659620298599163 0.78850798581046 MAEL/P3H4 2 GO:2000378 negative regulation of reactive oxygen species metabolic process 2/803 52/18722 0.659620298599163 0.78850798581046 CRYAB/STAT3 2 GO:0006352 DNA-templated transcription, initiation 5/803 130/18722 0.660278226371587 0.788916184205303 THRA/TWIST1/RSF1/SETX/MED13 5 GO:0007098 centrosome cycle 5/803 130/18722 0.660278226371587 0.788916184205303 PKD2/ROCK2/NIN/CEP44/MAP9 5 GO:0099504 synaptic vesicle cycle 7/803 181/18722 0.662967284848241 0.790844052600356 CASK/PTEN/STX2/STON1/PREPL/CANX/ITSN1 7 GO:0000245 spliceosomal complex assembly 3/803 79/18722 0.664471093267545 0.790844052600356 CELF2/SETX/LUC7L3 3 GO:0001895 retina homeostasis 3/803 79/18722 0.664471093267545 0.790844052600356 PROM1/B2M/HSPB1 3 GO:0040029 regulation of gene expression, epigenetic 4/803 105/18722 0.66456252793514 0.790844052600356 IGF2/XIST/ZMIZ1/IFI16 4 GO:2001022 positive regulation of response to DNA damage stimulus 4/803 105/18722 0.66456252793514 0.790844052600356 SPRED1/PLA2R1/SKIL/ATM 4 GO:0001964 startle response 1/803 25/18722 0.666015679275751 0.790844052600356 PTEN 1 GO:0010447 response to acidic pH 1/803 25/18722 0.666015679275751 0.790844052600356 SERPINF1 1 GO:0010996 response to auditory stimulus 1/803 25/18722 0.666015679275751 0.790844052600356 MDK 1 GO:0015874 norepinephrine transport 1/803 25/18722 0.666015679275751 0.790844052600356 SLC22A3 1 GO:0032469 endoplasmic reticulum calcium ion homeostasis 1/803 25/18722 0.666015679275751 0.790844052600356 CAMK2D 1 GO:0033233 regulation of protein sumoylation 1/803 25/18722 0.666015679275751 0.790844052600356 ZMIZ1 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/803 25/18722 0.666015679275751 0.790844052600356 ELOVL2 1 GO:0046835 carbohydrate phosphorylation 1/803 25/18722 0.666015679275751 0.790844052600356 GNPTG 1 GO:0046949 fatty-acyl-CoA biosynthetic process 1/803 25/18722 0.666015679275751 0.790844052600356 ELOVL2 1 GO:0048143 astrocyte activation 1/803 25/18722 0.666015679275751 0.790844052600356 LRP1 1 GO:0050927 positive regulation of positive chemotaxis 1/803 25/18722 0.666015679275751 0.790844052600356 F3 1 GO:0051788 response to misfolded protein 1/803 25/18722 0.666015679275751 0.790844052600356 CLU 1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 1/803 25/18722 0.666015679275751 0.790844052600356 MED13 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/803 25/18722 0.666015679275751 0.790844052600356 TMEM120A 1 GO:0070199 establishment of protein localization to chromosome 1/803 25/18722 0.666015679275751 0.790844052600356 TERF1 1 GO:0090382 phagosome maturation 1/803 25/18722 0.666015679275751 0.790844052600356 SRPX 1 GO:1901623 regulation of lymphocyte chemotaxis 1/803 25/18722 0.666015679275751 0.790844052600356 WNK1 1 GO:1902932 positive regulation of alcohol biosynthetic process 1/803 25/18722 0.666015679275751 0.790844052600356 PRKAA1 1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/803 25/18722 0.666015679275751 0.790844052600356 THBS1 1 GO:1903792 negative regulation of anion transport 1/803 25/18722 0.666015679275751 0.790844052600356 PLA2R1 1 GO:1904385 cellular response to angiotensin 1/803 25/18722 0.666015679275751 0.790844052600356 ROCK2 1 GO:0006402 mRNA catabolic process 9/803 232/18722 0.667849980205622 0.792833333644103 PRKCA/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/PUM2/ATM 9 GO:0060401 cytosolic calcium ion transport 7/803 182/18722 0.668576647855034 0.793507061700833 THY1/CAMK2D/PKD2/PRNP/ABL1/TPCN1/SLC8A1 7 GO:0001541 ovarian follicle development 2/803 53/18722 0.66986009882895 0.79408522414673 KITLG/FOXO3 2 GO:0016925 protein sumoylation 2/803 53/18722 0.66986009882895 0.79408522414673 PIAS2/ZMIZ1 2 GO:0033059 cellular pigmentation 2/803 53/18722 0.66986009882895 0.79408522414673 ZEB2/CD63 2 GO:0051438 regulation of ubiquitin-protein transferase activity 2/803 53/18722 0.66986009882895 0.79408522414673 PTEN/ABL1 2 GO:0071715 icosanoid transport 2/803 53/18722 0.66986009882895 0.79408522414673 PLA2G2A/PLA2R1 2 GO:0002793 positive regulation of peptide secretion 4/803 106/18722 0.671831010283592 0.796043112470054 CAMK2N1/GJA1/LRP1/ITSN1 4 GO:0006090 pyruvate metabolic process 4/803 106/18722 0.671831010283592 0.796043112470054 PDK4/NUPR1/STAT3/PRKAA1 4 GO:0021766 hippocampus development 3/803 80/18722 0.672799931079483 0.797001771528226 PTEN/MDK/NCOA1 3 GO:0006275 regulation of DNA replication 4/803 107/18722 0.678990145916084 0.799122088404575 ATRX/CCDC88A/TERF1/NUCKS1 4 GO:0021761 limbic system development 4/803 107/18722 0.678990145916084 0.799122088404575 PTEN/MDK/NRP2/NCOA1 4 GO:0036503 ERAD pathway 4/803 107/18722 0.678990145916084 0.799122088404575 MAN1A1/HSP90B1/AMFR/CANX 4 GO:2001257 regulation of cation channel activity 7/803 184/18722 0.679621486811147 0.799122088404575 CAMK2D/PKD2/AHNAK/ITGB1/IFNGR2/DAPK1/STOM 7 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 2/803 54/18722 0.679849027180772 0.799122088404575 BMP4/THBS1 2 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/803 54/18722 0.679849027180772 0.799122088404575 HLA-F/NDFIP1 2 GO:0006584 catecholamine metabolic process 2/803 54/18722 0.679849027180772 0.799122088404575 HAND2/EPAS1 2 GO:0007215 glutamate receptor signaling pathway 2/803 54/18722 0.679849027180772 0.799122088404575 PRNP/PLCB1 2 GO:0009712 catechol-containing compound metabolic process 2/803 54/18722 0.679849027180772 0.799122088404575 HAND2/EPAS1 2 GO:0035065 regulation of histone acetylation 2/803 54/18722 0.679849027180772 0.799122088404575 TWIST1/KMT2A 2 GO:0043647 inositol phosphate metabolic process 2/803 54/18722 0.679849027180772 0.799122088404575 PTEN/IPMK 2 GO:0070228 regulation of lymphocyte apoptotic process 2/803 54/18722 0.679849027180772 0.799122088404575 BMP4/PTEN 2 GO:0072348 sulfur compound transport 2/803 54/18722 0.679849027180772 0.799122088404575 GJA1/SLC19A3 2 GO:2000179 positive regulation of neural precursor cell proliferation 2/803 54/18722 0.679849027180772 0.799122088404575 FLNA/MDK 2 GO:2000300 regulation of synaptic vesicle exocytosis 2/803 54/18722 0.679849027180772 0.799122088404575 CASK/PREPL 2 GO:0002407 dendritic cell chemotaxis 1/803 26/18722 0.680359660103775 0.799122088404575 GAS6 1 GO:0002418 immune response to tumor cell 1/803 26/18722 0.680359660103775 0.799122088404575 HLA-A 1 GO:0002710 negative regulation of T cell mediated immunity 1/803 26/18722 0.680359660103775 0.799122088404575 HLA-F 1 GO:0006706 steroid catabolic process 1/803 26/18722 0.680359660103775 0.799122088404575 APOE 1 GO:0009435 NAD biosynthetic process 1/803 26/18722 0.680359660103775 0.799122088404575 NNMT 1 GO:0032515 negative regulation of phosphoprotein phosphatase activity 1/803 26/18722 0.680359660103775 0.799122088404575 ROCK2 1 GO:0042537 benzene-containing compound metabolic process 1/803 26/18722 0.680359660103775 0.799122088404575 GSTM3 1 GO:0043501 skeletal muscle adaptation 1/803 26/18722 0.680359660103775 0.799122088404575 IGFBP5 1 GO:0045026 plasma membrane fusion 1/803 26/18722 0.680359660103775 0.799122088404575 CD9 1 GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 1/803 26/18722 0.680359660103775 0.799122088404575 PRKCA 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/803 26/18722 0.680359660103775 0.799122088404575 HLA-F 1 GO:0048499 synaptic vesicle membrane organization 1/803 26/18722 0.680359660103775 0.799122088404575 STX2 1 GO:0050926 regulation of positive chemotaxis 1/803 26/18722 0.680359660103775 0.799122088404575 F3 1 GO:0051560 mitochondrial calcium ion homeostasis 1/803 26/18722 0.680359660103775 0.799122088404575 PDZD8 1 GO:0070977 bone maturation 1/803 26/18722 0.680359660103775 0.799122088404575 EXT1 1 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1/803 26/18722 0.680359660103775 0.799122088404575 AKAP13 1 GO:0097066 response to thyroid hormone 1/803 26/18722 0.680359660103775 0.799122088404575 GCLM 1 GO:0097186 amelogenesis 1/803 26/18722 0.680359660103775 0.799122088404575 FAM20C 1 GO:0099637 neurotransmitter receptor transport 1/803 26/18722 0.680359660103775 0.799122088404575 CLSTN1 1 GO:1900017 positive regulation of cytokine production involved in inflammatory response 1/803 26/18722 0.680359660103775 0.799122088404575 STAT3 1 GO:1901071 glucosamine-containing compound metabolic process 1/803 26/18722 0.680359660103775 0.799122088404575 PGM3 1 GO:0006096 glycolytic process 3/803 81/18722 0.680975741655579 0.799469048244577 NUPR1/STAT3/PRKAA1 3 GO:0010833 telomere maintenance via telomere lengthening 3/803 81/18722 0.680975741655579 0.799469048244577 TERF1/NEK7/ATM 3 GO:0002699 positive regulation of immune effector process 9/803 235/18722 0.682554292814009 0.801133640294409 SPON2/CD36/IL1R1/HLA-B/HLA-A/CD81/B2M/HLA-F/FER 9 GO:0022037 metencephalon development 4/803 108/18722 0.686039643925261 0.805034988141057 SERPINE2/MDK/ABL1/NCOA1 4 GO:0051321 meiotic cell cycle 10/803 261/18722 0.686870761822268 0.805820616104901 PDE3A/MAEL/HSPA2/PLCB1/CDC25B/PRKAR1A/ATRX/P3H4/TERF1/ATM 10 GO:0006757 ATP generation from ADP 3/803 82/18722 0.688998777549331 0.807490472472785 NUPR1/STAT3/PRKAA1 3 GO:0007032 endosome organization 3/803 82/18722 0.688998777549331 0.807490472472785 LAPTM4B/SCARB2/STAM2 3 GO:2001252 positive regulation of chromosome organization 3/803 82/18722 0.688998777549331 0.807490472472785 ATRX/NEK7/ATM 3 GO:0008333 endosome to lysosome transport 2/803 55/18722 0.689589737623169 0.807490472472785 BIN1/SORT1 2 GO:0045620 negative regulation of lymphocyte differentiation 2/803 55/18722 0.689589737623169 0.807490472472785 BMP4/MDK 2 GO:0046164 alcohol catabolic process 2/803 55/18722 0.689589737623169 0.807490472472785 APOE/PTEN 2 GO:0051898 negative regulation of protein kinase B signaling 2/803 55/18722 0.689589737623169 0.807490472472785 PTEN/KLF4 2 GO:0061098 positive regulation of protein tyrosine kinase activity 2/803 55/18722 0.689589737623169 0.807490472472785 GAS6/PRNP 2 GO:0031330 negative regulation of cellular catabolic process 10/803 262/18722 0.691417221540911 0.807636968073453 HGF/GATA4/TIMP1/LAPTM4B/TIMP3/TSPO/NUPR1/TIMP2/STAT3/CTSA 10 GO:0019318 hexose metabolic process 9/803 237/18722 0.692133838951582 0.807636968073453 ENPP1/APOD/NNMT/IGF2/IRS1/PDK4/H6PD/PRKAA1/FUCA2 9 GO:0051650 establishment of vesicle localization 6/803 161/18722 0.693605280380442 0.807636968073453 MYO1B/MYO1E/SAR1A/WASL/MYO1C/ACTN4 6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1/803 27/18722 0.694088328960037 0.807636968073453 ABL1 1 GO:0002825 regulation of T-helper 1 type immune response 1/803 27/18722 0.694088328960037 0.807636968073453 IL1R1 1 GO:0008053 mitochondrial fusion 1/803 27/18722 0.694088328960037 0.807636968073453 PID1 1 GO:0014850 response to muscle activity 1/803 27/18722 0.694088328960037 0.807636968073453 METRNL 1 GO:0015813 L-glutamate transmembrane transport 1/803 27/18722 0.694088328960037 0.807636968073453 ITGB1 1 GO:0018904 ether metabolic process 1/803 27/18722 0.694088328960037 0.807636968073453 LPCAT2 1 GO:0032703 negative regulation of interleukin-2 production 1/803 27/18722 0.694088328960037 0.807636968073453 PRNP 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/803 27/18722 0.694088328960037 0.807636968073453 MFHAS1 1 GO:0034377 plasma lipoprotein particle assembly 1/803 27/18722 0.694088328960037 0.807636968073453 APOE 1 GO:0034453 microtubule anchoring 1/803 27/18722 0.694088328960037 0.807636968073453 NIN 1 GO:0036037 CD8-positive, alpha-beta T cell activation 1/803 27/18722 0.694088328960037 0.807636968073453 HLA-A 1 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 1/803 27/18722 0.694088328960037 0.807636968073453 ABL1 1 GO:0039529 RIG-I signaling pathway 1/803 27/18722 0.694088328960037 0.807636968073453 PUM2 1 GO:0042745 circadian sleep/wake cycle 1/803 27/18722 0.694088328960037 0.807636968073453 PTGDS 1 GO:0045606 positive regulation of epidermal cell differentiation 1/803 27/18722 0.694088328960037 0.807636968073453 BMP4 1 GO:0046174 polyol catabolic process 1/803 27/18722 0.694088328960037 0.807636968073453 PTEN 1 GO:0046337 phosphatidylethanolamine metabolic process 1/803 27/18722 0.694088328960037 0.807636968073453 PLA2G2A 1 GO:0048520 positive regulation of behavior 1/803 27/18722 0.694088328960037 0.807636968073453 GJA1 1 GO:0048873 homeostasis of number of cells within a tissue 1/803 27/18722 0.694088328960037 0.807636968073453 CSF1 1 GO:0071624 positive regulation of granulocyte chemotaxis 1/803 27/18722 0.694088328960037 0.807636968073453 MDK 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/803 27/18722 0.694088328960037 0.807636968073453 ATP1B1 1 GO:1902883 negative regulation of response to oxidative stress 1/803 27/18722 0.694088328960037 0.807636968073453 HGF 1 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 1/803 27/18722 0.694088328960037 0.807636968073453 TERF1 1 GO:2000463 positive regulation of excitatory postsynaptic potential 1/803 27/18722 0.694088328960037 0.807636968073453 PTEN 1 GO:1903311 regulation of mRNA metabolic process 11/803 288/18722 0.69549666228423 0.809086877776289 PRKCA/TNRC6C/VIM/SON/CELF2/ROCK2/ZFP36L2/ZFP36L1/DDX17/MBNL2/PUM2 11 GO:0061136 regulation of proteasomal protein catabolic process 7/803 187/18722 0.695747977475475 0.809190439863009 APOE/PRICKLE1/PKD1/CLU/NUPR1/DAB2/HECTD1 7 GO:0046785 microtubule polymerization 3/803 83/18722 0.696869444628362 0.81011682231686 MAP1B/NIN/ABL1 3 GO:0061053 somite development 3/803 83/18722 0.696869444628362 0.81011682231686 LRP6/EPB41L5/MIB1 3 GO:0002090 regulation of receptor internalization 2/803 56/18722 0.699085117965595 0.811935336169685 ANGPT1/CD63 2 GO:0015800 acidic amino acid transport 2/803 56/18722 0.699085117965595 0.811935336169685 GJA1/ITGB1 2 GO:0031122 cytoplasmic microtubule organization 2/803 56/18722 0.699085117965595 0.811935336169685 DST/CCDC88A 2 GO:0031529 ruffle organization 2/803 56/18722 0.699085117965595 0.811935336169685 EPS8/TPM1 2 GO:0032611 interleukin-1 beta production 4/803 110/18722 0.699809057761707 0.812397662863765 CD36/STAT3/IFI16/HSPB1 4 GO:0032651 regulation of interleukin-1 beta production 4/803 110/18722 0.699809057761707 0.812397662863765 CD36/STAT3/IFI16/HSPB1 4 GO:0009117 nucleotide metabolic process 19/803 489/18722 0.704207930381981 0.815881317407141 ENPP1/NNMT/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/NADK2/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 19 GO:0006631 fatty acid metabolic process 15/803 390/18722 0.70427942568275 0.815881317407141 PTGDS/TNXB/ELOVL2/CD36/CES1/BDH2/IRS1/PDK4/ZADH2/LPGAT1/TWIST1/TNFRSF1A/LPIN1/PRKAA1/FADS3 15 GO:0098586 cellular response to virus 3/803 84/18722 0.704588293061718 0.815881317407141 EXT1/PUM2/TSPAN6 3 GO:0050684 regulation of mRNA processing 5/803 137/18722 0.704694393825757 0.815881317407141 SON/CELF2/ZFP36L1/DDX17/MBNL2 5 GO:0006633 fatty acid biosynthetic process 6/803 163/18722 0.704866769216466 0.815881317407141 PTGDS/ELOVL2/PDK4/LPGAT1/PRKAA1/FADS3 6 GO:0006516 glycoprotein catabolic process 1/803 28/18722 0.707228049304786 0.815881317407141 MAN1A1 1 GO:0006972 hyperosmotic response 1/803 28/18722 0.707228049304786 0.815881317407141 CLDN1 1 GO:0007141 male meiosis I 1/803 28/18722 0.707228049304786 0.815881317407141 HSPA2 1 GO:0010460 positive regulation of heart rate 1/803 28/18722 0.707228049304786 0.815881317407141 TPM1 1 GO:0010884 positive regulation of lipid storage 1/803 28/18722 0.707228049304786 0.815881317407141 CD36 1 GO:0031440 regulation of mRNA 3'-end processing 1/803 28/18722 0.707228049304786 0.815881317407141 ZFP36L1 1 GO:0032438 melanosome organization 1/803 28/18722 0.707228049304786 0.815881317407141 ZEB2 1 GO:0032801 receptor catabolic process 1/803 28/18722 0.707228049304786 0.815881317407141 APOE 1 GO:0032958 inositol phosphate biosynthetic process 1/803 28/18722 0.707228049304786 0.815881317407141 IPMK 1 GO:0038094 Fc-gamma receptor signaling pathway 1/803 28/18722 0.707228049304786 0.815881317407141 ABL1 1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1/803 28/18722 0.707228049304786 0.815881317407141 ITGA1 1 GO:0045589 regulation of regulatory T cell differentiation 1/803 28/18722 0.707228049304786 0.815881317407141 MDK 1 GO:0045686 negative regulation of glial cell differentiation 1/803 28/18722 0.707228049304786 0.815881317407141 TMEM98 1 GO:0051503 adenine nucleotide transport 1/803 28/18722 0.707228049304786 0.815881317407141 GJA1 1 GO:0060259 regulation of feeding behavior 1/803 28/18722 0.707228049304786 0.815881317407141 STAT3 1 GO:0062125 regulation of mitochondrial gene expression 1/803 28/18722 0.707228049304786 0.815881317407141 PRKAA1 1 GO:0071280 cellular response to copper ion 1/803 28/18722 0.707228049304786 0.815881317407141 PRNP 1 GO:0080111 DNA demethylation 1/803 28/18722 0.707228049304786 0.815881317407141 USP9X 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/803 28/18722 0.707228049304786 0.815881317407141 PLAUR 1 GO:0099623 regulation of cardiac muscle cell membrane repolarization 1/803 28/18722 0.707228049304786 0.815881317407141 FLNA 1 GO:1903779 regulation of cardiac conduction 1/803 28/18722 0.707228049304786 0.815881317407141 SLC8A1 1 GO:1990776 response to angiotensin 1/803 28/18722 0.707228049304786 0.815881317407141 ROCK2 1 GO:0006611 protein export from nucleus 2/803 57/18722 0.708338264970628 0.816217838951594 GAS6/PKD1 2 GO:0006754 ATP biosynthetic process 2/803 57/18722 0.708338264970628 0.816217838951594 PID1/STAT3 2 GO:0051205 protein insertion into membrane 2/803 57/18722 0.708338264970628 0.816217838951594 TRAM1/TRAM2 2 GO:0097120 receptor localization to synapse 2/803 57/18722 0.708338264970628 0.816217838951594 NPTN/CLSTN1 2 GO:1902017 regulation of cilium assembly 2/803 57/18722 0.708338264970628 0.816217838951594 YAP1/CCDC88A 2 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 3/803 85/18722 0.712156008600751 0.820048466254815 IL6ST/SOCS3/TNFRSF1A 3 GO:0072384 organelle transport along microtubule 3/803 85/18722 0.712156008600751 0.820048466254815 MAP1B/ARHGAP21/ARMCX3 3 GO:0097194 execution phase of apoptosis 3/803 85/18722 0.712156008600751 0.820048466254815 FAP/DLC1/TAOK1 3 GO:0000956 nuclear-transcribed mRNA catabolic process 4/803 112/18722 0.71313884577396 0.820801081493297 TNRC6C/ZFP36L2/ZFP36L1/ATM 4 GO:0046632 alpha-beta T cell differentiation 4/803 112/18722 0.71313884577396 0.820801081493297 TMEM98/TGFBR2/ABL1/STAT3 4 GO:0002764 immune response-regulating signaling pathway 18/803 468/18722 0.716480227423532 0.822774650423921 THY1/CD36/CMKLR1/HLA-A/MFHAS1/CD81/PRNP/TIFA/CMTM3/ABL1/WNK1/RTN4/FER/PUM2/PJA2/SOS1/BTN3A2/TSPAN6 18 GO:0009161 ribonucleoside monophosphate metabolic process 2/803 58/18722 0.717352461166316 0.822774650423921 CASK/MAGI3 2 GO:0043506 regulation of JUN kinase activity 2/803 58/18722 0.717352461166316 0.822774650423921 TNXB/HIPK3 2 GO:0006493 protein O-linked glycosylation 3/803 86/18722 0.719573404153404 0.822774650423921 GXYLT2/PGM3/GALNT1 3 GO:0032413 negative regulation of ion transmembrane transporter activity 3/803 86/18722 0.719573404153404 0.822774650423921 PTEN/CAMK2D/PKD2 3 GO:0046928 regulation of neurotransmitter secretion 3/803 86/18722 0.719573404153404 0.822774650423921 CASK/PREPL/MCTP2 3 GO:2001251 negative regulation of chromosome organization 3/803 86/18722 0.719573404153404 0.822774650423921 ATRX/TERF1/ATM 3 GO:0044106 cellular amine metabolic process 4/803 113/18722 0.719639140623894 0.822774650423921 HAND2/NNMT/SLC22A3/EPAS1 4 GO:0071347 cellular response to interleukin-1 4/803 113/18722 0.719639140623894 0.822774650423921 AKAP12/IL1R1/TFPI/PLCB1 4 GO:0043543 protein acylation 9/803 243/18722 0.719775606291708 0.822774650423921 KAT6B/TWIST1/NUPR1/KMT2A/TAOK1/PRKAA1/ZDHHC21/CLOCK/NCOA1 9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 1/803 29/18722 0.719804056387714 0.822774650423921 TNRC6C 1 GO:0002360 T cell lineage commitment 1/803 29/18722 0.719804056387714 0.822774650423921 STAT3 1 GO:0006656 phosphatidylcholine biosynthetic process 1/803 29/18722 0.719804056387714 0.822774650423921 CAPN2 1 GO:0006688 glycosphingolipid biosynthetic process 1/803 29/18722 0.719804056387714 0.822774650423921 PRKAA1 1 GO:0010458 exit from mitosis 1/803 29/18722 0.719804056387714 0.822774650423921 EPS8 1 GO:0015868 purine ribonucleotide transport 1/803 29/18722 0.719804056387714 0.822774650423921 GJA1 1 GO:0021591 ventricular system development 1/803 29/18722 0.719804056387714 0.822774650423921 SEMA6D 1 GO:0021602 cranial nerve morphogenesis 1/803 29/18722 0.719804056387714 0.822774650423921 NRP2 1 GO:0030970 retrograde protein transport, ER to cytosol 1/803 29/18722 0.719804056387714 0.822774650423921 HSP90B1 1 GO:0048753 pigment granule organization 1/803 29/18722 0.719804056387714 0.822774650423921 ZEB2 1 GO:0051873 killing by host of symbiont cells 1/803 29/18722 0.719804056387714 0.822774650423921 APOL1 1 GO:0051883 killing of cells in other organism involved in symbiotic interaction 1/803 29/18722 0.719804056387714 0.822774650423921 APOL1 1 GO:0062098 regulation of programmed necrotic cell death 1/803 29/18722 0.719804056387714 0.822774650423921 NUPR1 1 GO:0072539 T-helper 17 cell differentiation 1/803 29/18722 0.719804056387714 0.822774650423921 STAT3 1 GO:0090025 regulation of monocyte chemotaxis 1/803 29/18722 0.719804056387714 0.822774650423921 SLIT2 1 GO:0095500 acetylcholine receptor signaling pathway 1/803 29/18722 0.719804056387714 0.822774650423921 PLCB1 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/803 29/18722 0.719804056387714 0.822774650423921 PTEN 1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/803 29/18722 0.719804056387714 0.822774650423921 HSPB1 1 GO:1903513 endoplasmic reticulum to cytosol transport 1/803 29/18722 0.719804056387714 0.822774650423921 HSP90B1 1 GO:2000406 positive regulation of T cell migration 1/803 29/18722 0.719804056387714 0.822774650423921 WNK1 1 GO:0030307 positive regulation of cell growth 6/803 166/18722 0.721227504025246 0.824023908127837 MAP1B/LRP1/BMPR2/MACF1/GOLGA4/USP47 6 GO:0051236 establishment of RNA localization 6/803 166/18722 0.721227504025246 0.824023908127837 TGFBR2/ZFP36L1/SIDT2/MYO1C/TERF1/ATM 6 GO:0045088 regulation of innate immune response 8/803 218/18722 0.722529469996685 0.825322322429203 APOE/HLA-B/SERPING1/HLA-A/A2M/HLA-F/IFI16/SERPINB9 8 GO:0009416 response to light stimulus 12/803 320/18722 0.723524239885224 0.826269322049411 MMP2/MFAP4/TIMP1/MEIS2/EXT1/PTPRK/PIK3R1/ITGB1/NPTN/PRKAA1/CLOCK/USP47 12 GO:0046879 hormone secretion 11/803 295/18722 0.724661429160345 0.827378494571441 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 11 GO:0002286 T cell activation involved in immune response 4/803 114/18722 0.726030006428973 0.827919032734724 TMEM98/CD81/MDK/STAT3 4 GO:1904892 regulation of receptor signaling pathway via STAT 4/803 114/18722 0.726030006428973 0.827919032734724 PTPRD/PRLR/SOCS2/SOCS3 4 GO:0002820 negative regulation of adaptive immune response 2/803 59/18722 0.726131153258914 0.827919032734724 HLA-F/NDFIP1 2 GO:0006767 water-soluble vitamin metabolic process 2/803 59/18722 0.726131153258914 0.827919032734724 NNMT/SLC19A3 2 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 2/803 59/18722 0.726131153258914 0.827919032734724 THY1/SOCS3 2 GO:0051353 positive regulation of oxidoreductase activity 2/803 59/18722 0.726131153258914 0.827919032734724 APOE/ABL1 2 GO:1901606 alpha-amino acid catabolic process 3/803 87/18722 0.726841411650819 0.828350006512224 GLS/DDAH2/OAT 3 GO:2000177 regulation of neural precursor cell proliferation 3/803 87/18722 0.726841411650819 0.828350006512224 FLNA/MDK/FOXO3 3 GO:0006753 nucleoside phosphate metabolic process 19/803 497/18722 0.729822721074772 0.82893156753299 ENPP1/NNMT/GUCY1A2/ELOVL2/TPST1/ADCY3/PAPSS2/CASK/PDK4/RAB23/NUPR1/RHOQ/NADK2/PID1/MAGI3/STAT3/PRKAA1/PANK3/PAPSS1 19 GO:0031503 protein-containing complex localization 8/803 220/18722 0.731786834222423 0.82893156753299 AP2B1/PURA/NPTN/WASL/CLSTN1/TNFAIP2/TERF1/ATM 8 GO:0003299 muscle hypertrophy in response to stress 1/803 30/18722 0.731840505471364 0.82893156753299 GATA6 1 GO:0006884 cell volume homeostasis 1/803 30/18722 0.731840505471364 0.82893156753299 KCNMA1 1 GO:0007202 activation of phospholipase C activity 1/803 30/18722 0.731840505471364 0.82893156753299 LPAR1 1 GO:0010453 regulation of cell fate commitment 1/803 30/18722 0.731840505471364 0.82893156753299 BMP4 1 GO:0010669 epithelial structure maintenance 1/803 30/18722 0.731840505471364 0.82893156753299 LDB2 1 GO:0014887 cardiac muscle adaptation 1/803 30/18722 0.731840505471364 0.82893156753299 GATA6 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/803 30/18722 0.731840505471364 0.82893156753299 GATA6 1 GO:0015721 bile acid and bile salt transport 1/803 30/18722 0.731840505471364 0.82893156753299 PRKAA1 1 GO:0015865 purine nucleotide transport 1/803 30/18722 0.731840505471364 0.82893156753299 GJA1 1 GO:0019674 NAD metabolic process 1/803 30/18722 0.731840505471364 0.82893156753299 NADK2 1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 1/803 30/18722 0.731840505471364 0.82893156753299 B2M 1 GO:0031571 mitotic G1 DNA damage checkpoint signaling 1/803 30/18722 0.731840505471364 0.82893156753299 ATM 1 GO:0034390 smooth muscle cell apoptotic process 1/803 30/18722 0.731840505471364 0.82893156753299 LRP6 1 GO:0034391 regulation of smooth muscle cell apoptotic process 1/803 30/18722 0.731840505471364 0.82893156753299 LRP6 1 GO:0036258 multivesicular body assembly 1/803 30/18722 0.731840505471364 0.82893156753299 STAM2 1 GO:0043032 positive regulation of macrophage activation 1/803 30/18722 0.731840505471364 0.82893156753299 THBS1 1 GO:0043304 regulation of mast cell degranulation 1/803 30/18722 0.731840505471364 0.82893156753299 FER 1 GO:0044030 regulation of DNA methylation 1/803 30/18722 0.731840505471364 0.82893156753299 KMT2A 1 GO:0046825 regulation of protein export from nucleus 1/803 30/18722 0.731840505471364 0.82893156753299 GAS6 1 GO:0048799 animal organ maturation 1/803 30/18722 0.731840505471364 0.82893156753299 EXT1 1 GO:0060292 long-term synaptic depression 1/803 30/18722 0.731840505471364 0.82893156753299 PTEN 1 GO:0060603 mammary gland duct morphogenesis 1/803 30/18722 0.731840505471364 0.82893156753299 CSF1 1 GO:0070229 negative regulation of lymphocyte apoptotic process 1/803 30/18722 0.731840505471364 0.82893156753299 BMP4 1 GO:0140058 neuron projection arborization 1/803 30/18722 0.731840505471364 0.82893156753299 MACF1 1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 1/803 30/18722 0.731840505471364 0.82893156753299 PIK3R1 1 GO:0043087 regulation of GTPase activity 13/803 348/18722 0.733919278981824 0.831097325687798 THY1/PRKG1/EPHA3/CHN1/SPRY1/ITGB1/SBF2/GPR137B/ASAP1/WNK1/PLXNB2/EVI5/MAP4K4 13 GO:0009620 response to fungus 2/803 60/18722 0.734677932051659 0.831389961236853 RARRES2/SPON2 2 GO:0019731 antibacterial humoral response 2/803 60/18722 0.734677932051659 0.831389961236853 SPON2/HLA-A 2 GO:0035825 homologous recombination 2/803 60/18722 0.734677932051659 0.831389961236853 ATM/NUCKS1 2 GO:1901605 alpha-amino acid metabolic process 7/803 195/18722 0.736112985913342 0.832824903055122 PLOD2/GLS/SERINC3/DDAH2/SERINC5/GCLM/OAT 7 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 8/803 221/18722 0.736336059664582 0.832888292533486 APOE/PRICKLE1/PTEN/PKD1/CLU/NUPR1/DAB2/HECTD1 8 GO:0018394 peptidyl-lysine acetylation 6/803 169/18722 0.736947631060779 0.833390993075311 KAT6B/TWIST1/KMT2A/PRKAA1/CLOCK/NCOA1 6 GO:0070555 response to interleukin-1 5/803 143/18722 0.739414255253664 0.835990811041898 AKAP12/IL1R1/PRKCA/TFPI/PLCB1 5 GO:0019748 secondary metabolic process 2/803 61/18722 0.742996513780354 0.836091933843219 ZEB2/BDH2 2 GO:0043966 histone H3 acetylation 2/803 61/18722 0.742996513780354 0.836091933843219 KAT6B/KMT2A 2 GO:0001516 prostaglandin biosynthetic process 1/803 31/18722 0.743360517995786 0.836091933843219 PTGDS 1 GO:0002323 natural killer cell activation involved in immune response 1/803 31/18722 0.743360517995786 0.836091933843219 HLA-F 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/803 31/18722 0.743360517995786 0.836091933843219 HLA-F 1 GO:0006301 postreplication repair 1/803 31/18722 0.743360517995786 0.836091933843219 REV3L 1 GO:0007190 activation of adenylate cyclase activity 1/803 31/18722 0.743360517995786 0.836091933843219 VIPR2 1 GO:0030149 sphingolipid catabolic process 1/803 31/18722 0.743360517995786 0.836091933843219 ENPP2 1 GO:0033006 regulation of mast cell activation involved in immune response 1/803 31/18722 0.743360517995786 0.836091933843219 FER 1 GO:0033238 regulation of cellular amine metabolic process 1/803 31/18722 0.743360517995786 0.836091933843219 NNMT 1 GO:0035510 DNA dealkylation 1/803 31/18722 0.743360517995786 0.836091933843219 USP9X 1 GO:0036257 multivesicular body organization 1/803 31/18722 0.743360517995786 0.836091933843219 STAM2 1 GO:0042133 neurotransmitter metabolic process 1/803 31/18722 0.743360517995786 0.836091933843219 ALDH9A1 1 GO:0044819 mitotic G1/S transition checkpoint signaling 1/803 31/18722 0.743360517995786 0.836091933843219 ATM 1 GO:0045066 regulatory T cell differentiation 1/803 31/18722 0.743360517995786 0.836091933843219 MDK 1 GO:0045987 positive regulation of smooth muscle contraction 1/803 31/18722 0.743360517995786 0.836091933843219 SPX 1 GO:0046457 prostanoid biosynthetic process 1/803 31/18722 0.743360517995786 0.836091933843219 PTGDS 1 GO:0048384 retinoic acid receptor signaling pathway 1/803 31/18722 0.743360517995786 0.836091933843219 ACTN4 1 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1/803 31/18722 0.743360517995786 0.836091933843219 PTEN 1 GO:0060055 angiogenesis involved in wound healing 1/803 31/18722 0.743360517995786 0.836091933843219 SMOC2 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/803 31/18722 0.743360517995786 0.836091933843219 THY1 1 GO:0070633 transepithelial transport 1/803 31/18722 0.743360517995786 0.836091933843219 EDNRB 1 GO:1900027 regulation of ruffle assembly 1/803 31/18722 0.743360517995786 0.836091933843219 EPS8 1 GO:0007612 learning 5/803 144/18722 0.744899625235866 0.837445215654121 ADCY3/MEIS2/ITGB1/NPTN/ATXN1 5 GO:0033135 regulation of peptidyl-serine phosphorylation 5/803 144/18722 0.744899625235866 0.837445215654121 HGF/GAS6/ANGPT1/PTEN/PRKAA1 5 GO:0046883 regulation of hormone secretion 9/803 249/18722 0.74573987433665 0.838200859657921 CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 9 GO:0035278 miRNA mediated inhibition of translation 3/803 90/18722 0.747760047781723 0.839903491380867 TNRC6C/AGO3/STAT3 3 GO:0040033 negative regulation of translation, ncRNA-mediated 3/803 90/18722 0.747760047781723 0.839903491380867 TNRC6C/AGO3/STAT3 3 GO:0046031 ADP metabolic process 3/803 90/18722 0.747760047781723 0.839903491380867 NUPR1/STAT3/PRKAA1 3 GO:1903313 positive regulation of mRNA metabolic process 4/803 118/18722 0.75050673356786 0.842695396892036 TNRC6C/ROCK2/ZFP36L2/ZFP36L1 4 GO:0007062 sister chromatid cohesion 2/803 62/18722 0.75109072278143 0.842695396892036 PDS5B/ATRX 2 GO:0032613 interleukin-10 production 2/803 62/18722 0.75109072278143 0.842695396892036 HGF/STAT3 2 GO:0032653 regulation of interleukin-10 production 2/803 62/18722 0.75109072278143 0.842695396892036 HGF/STAT3 2 GO:0032757 positive regulation of interleukin-8 production 2/803 62/18722 0.75109072278143 0.842695396892036 F3/STAT3 2 GO:0008156 negative regulation of DNA replication 1/803 32/18722 0.754386225772223 0.843418718540389 TERF1 1 GO:0030431 sleep 1/803 32/18722 0.754386225772223 0.843418718540389 PTGDS 1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 1/803 32/18722 0.754386225772223 0.843418718540389 ZMYND11 1 GO:0045684 positive regulation of epidermis development 1/803 32/18722 0.754386225772223 0.843418718540389 BMP4 1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1/803 32/18722 0.754386225772223 0.843418718540389 PTEN 1 GO:0046475 glycerophospholipid catabolic process 1/803 32/18722 0.754386225772223 0.843418718540389 ENPP2 1 GO:0046856 phosphatidylinositol dephosphorylation 1/803 32/18722 0.754386225772223 0.843418718540389 PTEN 1 GO:0050850 positive regulation of calcium-mediated signaling 1/803 32/18722 0.754386225772223 0.843418718540389 LMCD1 1 GO:0051642 centrosome localization 1/803 32/18722 0.754386225772223 0.843418718540389 NIN 1 GO:0090140 regulation of mitochondrial fission 1/803 32/18722 0.754386225772223 0.843418718540389 DCN 1 GO:0097345 mitochondrial outer membrane permeabilization 1/803 32/18722 0.754386225772223 0.843418718540389 BNIP3L 1 GO:1901185 negative regulation of ERBB signaling pathway 1/803 32/18722 0.754386225772223 0.843418718540389 ITGA1 1 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 1/803 32/18722 0.754386225772223 0.843418718540389 TWSG1 1 GO:0006354 DNA-templated transcription, elongation 3/803 91/18722 0.754441934354219 0.843418718540389 ZMYND11/ZMIZ1/RTF1 3 GO:0045582 positive regulation of T cell differentiation 3/803 91/18722 0.754441934354219 0.843418718540389 MDK/TGFBR2/ZMIZ1 3 GO:0045974 regulation of translation, ncRNA-mediated 3/803 91/18722 0.754441934354219 0.843418718540389 TNRC6C/AGO3/STAT3 3 GO:0015711 organic anion transport 13/803 354/18722 0.755293966965016 0.844181959042271 PLA2G2A/SLC22A3/CD36/GJA1/CES1/SLC2A10/SLC16A7/SERINC3/ITGB1/SLC38A2/PLA2R1/PRKAA1/SERINC5 13 GO:0031398 positive regulation of protein ubiquitination 4/803 119/18722 0.756356719497508 0.845180323490492 ANGPT1/PRICKLE1/PTEN/NDFIP1 4 GO:0010469 regulation of signaling receptor activity 6/803 173/18722 0.756911381739354 0.845610609310423 DKK3/PLAU/PTEN/ITGB1/IFNGR2/DAPK1 6 GO:0006486 protein glycosylation 8/803 226/18722 0.758285525473988 0.846766322511379 GXYLT2/MAN1A1/RAMP1/EXT1/PGM3/GALNT1/TMEM59/DPY19L4 8 GO:0043413 macromolecule glycosylation 8/803 226/18722 0.758285525473988 0.846766322511379 GXYLT2/MAN1A1/RAMP1/EXT1/PGM3/GALNT1/TMEM59/DPY19L4 8 GO:0046902 regulation of mitochondrial membrane permeability 2/803 63/18722 0.758964475412737 0.846955432947159 STAT3/BNIP3L 2 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 2/803 63/18722 0.758964475412737 0.846955432947159 CREB3L1/SERINC3 2 GO:0099601 regulation of neurotransmitter receptor activity 2/803 63/18722 0.758964475412737 0.846955432947159 IFNGR2/DAPK1 2 GO:0001708 cell fate specification 3/803 92/18722 0.760980613378457 0.848445737545838 TBX2/HOXA13/ITGB1 3 GO:0031058 positive regulation of histone modification 3/803 92/18722 0.760980613378457 0.848445737545838 KMT2A/KMT2E/RTF1 3 GO:0032465 regulation of cytokinesis 3/803 92/18722 0.760980613378457 0.848445737545838 CDC25B/MAP9/KLHL9 3 GO:1903351 cellular response to dopamine 3/803 92/18722 0.760980613378457 0.848445737545838 PALM/FLNA/ABL1 3 GO:0072655 establishment of protein localization to mitochondrion 4/803 120/18722 0.762100242876886 0.849250706538257 TSPO/NPEPPS/PRKAA1/BNIP3L 4 GO:0065004 protein-DNA complex assembly 7/803 201/18722 0.763838249740704 0.849250706538257 TCF4/THRA/KAT6B/RSF1/ATRX/SHPRH/TERF1 7 GO:0001881 receptor recycling 1/803 33/18722 0.764938813289874 0.849250706538257 ECE1 1 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/803 33/18722 0.764938813289874 0.849250706538257 ABL1 1 GO:0006336 DNA replication-independent nucleosome assembly 1/803 33/18722 0.764938813289874 0.849250706538257 ATRX 1 GO:0006891 intra-Golgi vesicle-mediated transport 1/803 33/18722 0.764938813289874 0.849250706538257 COPZ2 1 GO:0009648 photoperiodism 1/803 33/18722 0.764938813289874 0.849250706538257 CLOCK 1 GO:0010259 multicellular organism aging 1/803 33/18722 0.764938813289874 0.849250706538257 CRYAB 1 GO:0018345 protein palmitoylation 1/803 33/18722 0.764938813289874 0.849250706538257 ZDHHC21 1 GO:0021696 cerebellar cortex morphogenesis 1/803 33/18722 0.764938813289874 0.849250706538257 SERPINE2 1 GO:0032228 regulation of synaptic transmission, GABAergic 1/803 33/18722 0.764938813289874 0.849250706538257 PTEN 1 GO:0032633 interleukin-4 production 1/803 33/18722 0.764938813289874 0.849250706538257 NDFIP1 1 GO:0032673 regulation of interleukin-4 production 1/803 33/18722 0.764938813289874 0.849250706538257 NDFIP1 1 GO:0060122 inner ear receptor cell stereocilium organization 1/803 33/18722 0.764938813289874 0.849250706538257 CTHRC1 1 GO:0061842 microtubule organizing center localization 1/803 33/18722 0.764938813289874 0.849250706538257 NIN 1 GO:1901099 negative regulation of signal transduction in absence of ligand 1/803 33/18722 0.764938813289874 0.849250706538257 SNAI2 1 GO:1902275 regulation of chromatin organization 1/803 33/18722 0.764938813289874 0.849250706538257 MLLT3 1 GO:2000036 regulation of stem cell population maintenance 1/803 33/18722 0.764938813289874 0.849250706538257 YAP1 1 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/803 33/18722 0.764938813289874 0.849250706538257 SNAI2 1 GO:0030858 positive regulation of epithelial cell differentiation 2/803 64/18722 0.766621765151723 0.850651695439312 BMP4/PROM1 2 GO:0030888 regulation of B cell proliferation 2/803 64/18722 0.766621765151723 0.850651695439312 CD81/ATM 2 GO:0009914 hormone transport 11/803 306/18722 0.766712538969969 0.850651695439312 SLC16A10/LTBP4/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/ITSN1/CLOCK 11 GO:0045132 meiotic chromosome segregation 3/803 93/18722 0.767377576176929 0.851010808455999 MAEL/P3H4/TERF1 3 GO:1903350 response to dopamine 3/803 93/18722 0.767377576176929 0.851010808455999 PALM/FLNA/ABL1 3 GO:0002224 toll-like receptor signaling pathway 4/803 121/18722 0.767738012552773 0.85122119870761 CD36/MFHAS1/RTN4/PJA2 4 GO:0032091 negative regulation of protein binding 3/803 94/18722 0.773634384110948 0.855132164475771 B2M/DAB2/EPB41L5 3 GO:0035418 protein localization to synapse 2/803 65/18722 0.77406664879976 0.855132164475771 CLSTN1/HSPB1 2 GO:0070936 protein K48-linked ubiquitination 2/803 65/18722 0.77406664879976 0.855132164475771 TTC3/AMFR 2 GO:0071677 positive regulation of mononuclear cell migration 2/803 65/18722 0.77406664879976 0.855132164475771 GAS6/WNK1 2 GO:0090307 mitotic spindle assembly 2/803 65/18722 0.77406664879976 0.855132164475771 FLNA/MAP9 2 GO:0000038 very long-chain fatty acid metabolic process 1/803 34/18722 0.775038558216207 0.855132164475771 ELOVL2 1 GO:0000096 sulfur amino acid metabolic process 1/803 34/18722 0.775038558216207 0.855132164475771 GCLM 1 GO:0002183 cytoplasmic translational initiation 1/803 34/18722 0.775038558216207 0.855132164475771 EIF4A2 1 GO:0002446 neutrophil mediated immunity 1/803 34/18722 0.775038558216207 0.855132164475771 KMT2E 1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 1/803 34/18722 0.775038558216207 0.855132164475771 B2M 1 GO:0006270 DNA replication initiation 1/803 34/18722 0.775038558216207 0.855132164475771 PURA 1 GO:0006356 regulation of transcription by RNA polymerase I 1/803 34/18722 0.775038558216207 0.855132164475771 FLNA 1 GO:0010614 negative regulation of cardiac muscle hypertrophy 1/803 34/18722 0.775038558216207 0.855132164475771 TNFRSF1A 1 GO:0016242 negative regulation of macroautophagy 1/803 34/18722 0.775038558216207 0.855132164475771 NUPR1 1 GO:0030851 granulocyte differentiation 1/803 34/18722 0.775038558216207 0.855132164475771 SP3 1 GO:0032770 positive regulation of monooxygenase activity 1/803 34/18722 0.775038558216207 0.855132164475771 APOE 1 GO:0034383 low-density lipoprotein particle clearance 1/803 34/18722 0.775038558216207 0.855132164475771 CD36 1 GO:0034724 DNA replication-independent nucleosome organization 1/803 34/18722 0.775038558216207 0.855132164475771 ATRX 1 GO:0051085 chaperone cofactor-dependent protein refolding 1/803 34/18722 0.775038558216207 0.855132164475771 HSPA2 1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 1/803 34/18722 0.775038558216207 0.855132164475771 LPAR1 1 GO:0070232 regulation of T cell apoptotic process 1/803 34/18722 0.775038558216207 0.855132164475771 BMP4 1 GO:2000758 positive regulation of peptidyl-lysine acetylation 1/803 34/18722 0.775038558216207 0.855132164475771 PRKAA1 1 GO:0071466 cellular response to xenobiotic stimulus 6/803 177/18722 0.775743817038835 0.855720945078679 GAS6/PRNP/RAP2A/PRKAA1/GSTM3/NCOA1 6 GO:0005996 monosaccharide metabolic process 9/803 257/18722 0.777718209615562 0.857709133630434 ENPP1/APOD/NNMT/IGF2/IRS1/PDK4/H6PD/PRKAA1/FUCA2 9 GO:0009266 response to temperature stimulus 6/803 178/18722 0.780276835411343 0.860340623918832 THBS1/THRA/HSPA2/METRNL/PRKAA1/ATM 6 GO:0032715 negative regulation of interleukin-6 production 2/803 66/18722 0.781303233725373 0.860901198531428 HGF/GAS6 2 GO:0042093 T-helper cell differentiation 2/803 66/18722 0.781303233725373 0.860901198531428 TMEM98/STAT3 2 GO:2000272 negative regulation of signaling receptor activity 2/803 66/18722 0.781303233725373 0.860901198531428 DKK3/PTEN 2 GO:0000731 DNA synthesis involved in DNA repair 1/803 35/18722 0.784704870167854 0.861792617325313 REV3L 1 GO:0006084 acetyl-CoA metabolic process 1/803 35/18722 0.784704870167854 0.861792617325313 PDK4 1 GO:0006298 mismatch repair 1/803 35/18722 0.784704870167854 0.861792617325313 ABL1 1 GO:0007020 microtubule nucleation 1/803 35/18722 0.784704870167854 0.861792617325313 NIN 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/803 35/18722 0.784704870167854 0.861792617325313 EML4 1 GO:0019068 virion assembly 1/803 35/18722 0.784704870167854 0.861792617325313 APOE 1 GO:0039694 viral RNA genome replication 1/803 35/18722 0.784704870167854 0.861792617325313 ROCK2 1 GO:0045454 cell redox homeostasis 1/803 35/18722 0.784704870167854 0.861792617325313 SLC2A10 1 GO:0045907 positive regulation of vasoconstriction 1/803 35/18722 0.784704870167854 0.861792617325313 GJA1 1 GO:0046471 phosphatidylglycerol metabolic process 1/803 35/18722 0.784704870167854 0.861792617325313 LPGAT1 1 GO:0071108 protein K48-linked deubiquitination 1/803 35/18722 0.784704870167854 0.861792617325313 USP9X 1 GO:0086005 ventricular cardiac muscle cell action potential 1/803 35/18722 0.784704870167854 0.861792617325313 BIN1 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/803 35/18722 0.784704870167854 0.861792617325313 ABL1 1 GO:0097502 mannosylation 1/803 35/18722 0.784704870167854 0.861792617325313 DPY19L4 1 GO:2000403 positive regulation of lymphocyte migration 1/803 35/18722 0.784704870167854 0.861792617325313 WNK1 1 GO:0016573 histone acetylation 5/803 152/18722 0.785728562773966 0.862542977038079 KAT6B/TWIST1/KMT2A/CLOCK/NCOA1 5 GO:0043648 dicarboxylic acid metabolic process 3/803 96/18722 0.785734095809658 0.862542977038079 GLS/GCLM/OAT 3 GO:0035914 skeletal muscle cell differentiation 2/803 67/18722 0.788335666082783 0.865017964588195 NUPR1/DDX17 2 GO:0043967 histone H4 acetylation 2/803 67/18722 0.788335666082783 0.865017964588195 KMT2A/NCOA1 2 GO:0070585 protein localization to mitochondrion 4/803 125/18722 0.789247506913566 0.865827958079437 TSPO/NPEPPS/PRKAA1/BNIP3L 4 GO:0006836 neurotransmitter transport 7/803 208/18722 0.793438615870944 0.868509488929301 SLC22A3/CASK/STX2/ITGB1/SLC38A2/PREPL/MCTP2 7 GO:0010923 negative regulation of phosphatase activity 1/803 36/18722 0.793956327825863 0.868509488929301 ROCK2 1 GO:0042755 eating behavior 1/803 36/18722 0.793956327825863 0.868509488929301 STAT3 1 GO:0044060 regulation of endocrine process 1/803 36/18722 0.793956327825863 0.868509488929301 GJA1 1 GO:0045191 regulation of isotype switching 1/803 36/18722 0.793956327825863 0.868509488929301 NDFIP1 1 GO:0045746 negative regulation of Notch signaling pathway 1/803 36/18722 0.793956327825863 0.868509488929301 DLK1 1 GO:0046466 membrane lipid catabolic process 1/803 36/18722 0.793956327825863 0.868509488929301 ENPP2 1 GO:0051385 response to mineralocorticoid 1/803 36/18722 0.793956327825863 0.868509488929301 FOXO3 1 GO:0051955 regulation of amino acid transport 1/803 36/18722 0.793956327825863 0.868509488929301 ITGB1 1 GO:0070897 transcription preinitiation complex assembly 1/803 36/18722 0.793956327825863 0.868509488929301 THRA 1 GO:0086010 membrane depolarization during action potential 1/803 36/18722 0.793956327825863 0.868509488929301 SLC8A1 1 GO:1901658 glycosyl compound catabolic process 1/803 36/18722 0.793956327825863 0.868509488929301 FUCA2 1 GO:1903539 protein localization to postsynaptic membrane 1/803 36/18722 0.793956327825863 0.868509488929301 CLSTN1 1 GO:0016052 carbohydrate catabolic process 5/803 154/18722 0.79510311666979 0.868881929881564 NUPR1/SCARB2/STAT3/PRKAA1/RB1CC1 5 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 2/803 68/18722 0.795168119945763 0.868881929881564 TMEM98/STAT3 2 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 2/803 68/18722 0.795168119945763 0.868881929881564 PID1/STAT3 2 GO:0031640 killing of cells of other organism 2/803 68/18722 0.795168119945763 0.868881929881564 APOL1/SERPINB9 2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 2/803 68/18722 0.795168119945763 0.868881929881564 IL6ST/TNFRSF1A 2 GO:0003333 amino acid transmembrane transport 3/803 98/18722 0.797293421843323 0.871013365756093 SLC16A10/ITGB1/SLC38A2 3 GO:0002768 immune response-regulating cell surface receptor signaling pathway 11/803 315/18722 0.797639086794062 0.871200106627643 THY1/CMKLR1/HLA-A/CD81/PRNP/CMTM3/ABL1/WNK1/FER/SOS1/BTN3A2 11 GO:0046395 carboxylic acid catabolic process 8/803 236/18722 0.79821809829043 0.871641576451179 CRABP1/BDH2/IRS1/GLS/TWIST1/LPIN1/DDAH2/OAT 8 GO:0006911 phagocytosis, engulfment 4/803 127/18722 0.799389741005386 0.871762715348465 CD36/THBS1/MFGE8/GSN 4 GO:0043414 macromolecule methylation 11/803 316/18722 0.800883109364093 0.871762715348465 NNMT/PRDM6/MAEL/TRMT44/KMT2A/ASH1L/ATRX/RNMT/KMT2E/RTF1/ICMT 11 GO:0071103 DNA conformation change 10/803 290/18722 0.801737182994672 0.871762715348465 CHD9/KAT6B/RSF1/ABL1/PURA/ATRX/SETX/SHPRH/RECQL/NAV2 10 GO:0002287 alpha-beta T cell activation involved in immune response 2/803 69/18722 0.801804787300108 0.871762715348465 TMEM98/STAT3 2 GO:0002293 alpha-beta T cell differentiation involved in immune response 2/803 69/18722 0.801804787300108 0.871762715348465 TMEM98/STAT3 2 GO:0009145 purine nucleoside triphosphate biosynthetic process 2/803 69/18722 0.801804787300108 0.871762715348465 PID1/STAT3 2 GO:0019226 transmission of nerve impulse 2/803 69/18722 0.801804787300108 0.871762715348465 NFASC/PLEC 2 GO:0034605 cellular response to heat 2/803 69/18722 0.801804787300108 0.871762715348465 THBS1/ATM 2 GO:0050688 regulation of defense response to virus 2/803 69/18722 0.801804787300108 0.871762715348465 HTRA1/TSPAN6 2 GO:0050805 negative regulation of synaptic transmission 2/803 69/18722 0.801804787300108 0.871762715348465 PTEN/GNAI1 2 GO:0001990 regulation of systemic arterial blood pressure by hormone 1/803 37/18722 0.802810714465906 0.871762715348465 ECE1 1 GO:0006862 nucleotide transport 1/803 37/18722 0.802810714465906 0.871762715348465 GJA1 1 GO:0021532 neural tube patterning 1/803 37/18722 0.802810714465906 0.871762715348465 BMP4 1 GO:0031646 positive regulation of nervous system process 1/803 37/18722 0.802810714465906 0.871762715348465 HGF 1 GO:0033363 secretory granule organization 1/803 37/18722 0.802810714465906 0.871762715348465 SERPINE2 1 GO:0042178 xenobiotic catabolic process 1/803 37/18722 0.802810714465906 0.871762715348465 GSTM3 1 GO:0043368 positive T cell selection 1/803 37/18722 0.802810714465906 0.871762715348465 STAT3 1 GO:0050775 positive regulation of dendrite morphogenesis 1/803 37/18722 0.802810714465906 0.871762715348465 PTPRD 1 GO:0051954 positive regulation of amine transport 1/803 37/18722 0.802810714465906 0.871762715348465 ITGB1 1 GO:0060306 regulation of membrane repolarization 1/803 37/18722 0.802810714465906 0.871762715348465 FLNA 1 GO:0062237 protein localization to postsynapse 1/803 37/18722 0.802810714465906 0.871762715348465 CLSTN1 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/803 37/18722 0.802810714465906 0.871762715348465 APOD 1 GO:0006165 nucleoside diphosphate phosphorylation 3/803 99/18722 0.802874927573235 0.871762715348465 NUPR1/STAT3/PRKAA1 3 GO:0007631 feeding behavior 3/803 99/18722 0.802874927573235 0.871762715348465 HAND2/GLS/STAT3 3 GO:0021510 spinal cord development 3/803 99/18722 0.802874927573235 0.871762715348465 PKD1/PKD2/VLDLR 3 GO:0042100 B cell proliferation 3/803 99/18722 0.802874927573235 0.871762715348465 CD81/ABL1/ATM 3 GO:0006639 acylglycerol metabolic process 4/803 128/18722 0.804311121116807 0.873131994314914 TNXB/APOE/LPGAT1/LPIN1 4 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 2/803 70/18722 0.808249868841221 0.877109345912704 B2M/NDFIP1 2 GO:0006910 phagocytosis, recognition 3/803 100/18722 0.808326803944821 0.877109345912704 SPON2/CD36/MFGE8 3 GO:0006334 nucleosome assembly 4/803 129/18722 0.809134063038972 0.877603314838441 KAT6B/RSF1/ATRX/SHPRH 4 GO:0006638 neutral lipid metabolic process 4/803 129/18722 0.809134063038972 0.877603314838441 TNXB/APOE/LPGAT1/LPIN1 4 GO:0007094 mitotic spindle assembly checkpoint signaling 1/803 38/18722 0.811285051971064 0.878216949441538 ATM 1 GO:0032717 negative regulation of interleukin-8 production 1/803 38/18722 0.811285051971064 0.878216949441538 KLF4 1 GO:0032941 secretion by tissue 1/803 38/18722 0.811285051971064 0.878216949441538 WNK1 1 GO:0035337 fatty-acyl-CoA metabolic process 1/803 38/18722 0.811285051971064 0.878216949441538 ELOVL2 1 GO:0042491 inner ear auditory receptor cell differentiation 1/803 38/18722 0.811285051971064 0.878216949441538 JAG1 1 GO:0071173 spindle assembly checkpoint signaling 1/803 38/18722 0.811285051971064 0.878216949441538 ATM 1 GO:0071174 mitotic spindle checkpoint signaling 1/803 38/18722 0.811285051971064 0.878216949441538 ATM 1 GO:0072538 T-helper 17 type immune response 1/803 38/18722 0.811285051971064 0.878216949441538 STAT3 1 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1/803 38/18722 0.811285051971064 0.878216949441538 BNIP3L 1 GO:0016054 organic acid catabolic process 8/803 240/18722 0.812734411720435 0.878993795355865 CRABP1/BDH2/IRS1/GLS/TWIST1/LPIN1/DDAH2/OAT 8 GO:0050851 antigen receptor-mediated signaling pathway 8/803 240/18722 0.812734411720435 0.878993795355865 THY1/HLA-A/CD81/PRNP/CMTM3/ABL1/WNK1/BTN3A2 8 GO:0070085 glycosylation 8/803 240/18722 0.812734411720435 0.878993795355865 GXYLT2/MAN1A1/RAMP1/EXT1/PGM3/GALNT1/TMEM59/DPY19L4 8 GO:0001505 regulation of neurotransmitter levels 7/803 213/18722 0.812807985427655 0.878993795355865 SLC22A3/CASK/STX2/ITGB1/ALDH9A1/PREPL/MCTP2 7 GO:0018393 internal peptidyl-lysine acetylation 5/803 158/18722 0.81288415370756 0.878993795355865 KAT6B/TWIST1/KMT2A/CLOCK/NCOA1 5 GO:0046939 nucleotide phosphorylation 3/803 101/18722 0.813650950976003 0.879632185942401 NUPR1/STAT3/PRKAA1 3 GO:0030534 adult behavior 4/803 130/18722 0.813859645155397 0.879667069313854 CCND2/PREX2/PTEN/EPS8 4 GO:0032722 positive regulation of chemokine production 2/803 71/18722 0.814507565526294 0.879985855192655 LRP1/TWIST1 2 GO:0061515 myeloid cell development 2/803 71/18722 0.814507565526294 0.879985855192655 NOTCH2/FBN1 2 GO:0071824 protein-DNA complex subunit organization 8/803 241/18722 0.816236147334714 0.881662354985027 TCF4/THRA/KAT6B/RSF1/ATRX/SHPRH/TERF1/BPTF 8 GO:0044242 cellular lipid catabolic process 7/803 214/18722 0.81650836335296 0.881765367051735 ENPP2/CRABP1/BDH2/IRS1/LRP1/TWIST1/LPIN1 7 GO:0050708 regulation of protein secretion 9/803 268/18722 0.816802892630675 0.881892425867593 APOE/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/CLOCK 9 GO:0000723 telomere maintenance 4/803 131/18722 0.818488973804787 0.882780170287835 ATRX/TERF1/NEK7/ATM 4 GO:0032677 regulation of interleukin-8 production 3/803 102/18722 0.818849298257699 0.882780170287835 F3/KLF4/STAT3 3 GO:0001941 postsynaptic membrane organization 1/803 39/18722 0.819395633391918 0.882780170287835 APOE 1 GO:0031577 spindle checkpoint signaling 1/803 39/18722 0.819395633391918 0.882780170287835 ATM 1 GO:0032506 cytokinetic process 1/803 39/18722 0.819395633391918 0.882780170287835 PLEC 1 GO:0036297 interstrand cross-link repair 1/803 39/18722 0.819395633391918 0.882780170287835 NUCKS1 1 GO:0045823 positive regulation of heart contraction 1/803 39/18722 0.819395633391918 0.882780170287835 TPM1 1 GO:0051084 'de novo' posttranslational protein folding 1/803 39/18722 0.819395633391918 0.882780170287835 HSPA2 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/803 39/18722 0.819395633391918 0.882780170287835 FRS2 1 GO:2000785 regulation of autophagosome assembly 1/803 39/18722 0.819395633391918 0.882780170287835 NUPR1 1 GO:1903320 regulation of protein modification by small protein conjugation or removal 8/803 242/18722 0.819687494861849 0.882903834387812 ANGPT1/PRICKLE1/PTEN/EPAS1/TSPO/ABL1/ZMIZ1/NDFIP1 8 GO:0070227 lymphocyte apoptotic process 2/803 72/18722 0.820582070833423 0.88367650219772 BMP4/PTEN 2 GO:0006475 internal protein amino acid acetylation 5/803 160/18722 0.821301378234644 0.884260132126524 KAT6B/TWIST1/KMT2A/CLOCK/NCOA1 5 GO:0001906 cell killing 6/803 188/18722 0.821852142674954 0.884662086221356 HLA-B/HLA-A/APOL1/B2M/HLA-F/SERPINB9 6 GO:0032637 interleukin-8 production 3/803 103/18722 0.823923800917797 0.886700641350342 F3/KLF4/STAT3 3 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/803 40/18722 0.827158054115907 0.888838374530585 MFHAS1 1 GO:0045740 positive regulation of DNA replication 1/803 40/18722 0.827158054115907 0.888838374530585 ATRX 1 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 1/803 40/18722 0.827158054115907 0.888838374530585 ATM 1 GO:0070266 necroptotic process 1/803 40/18722 0.827158054115907 0.888838374530585 IPMK 1 GO:0150077 regulation of neuroinflammatory response 1/803 40/18722 0.827158054115907 0.888838374530585 NUPR1 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/803 40/18722 0.827158054115907 0.888838374530585 PKD2 1 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 1/803 40/18722 0.827158054115907 0.888838374530585 BNIP3L 1 GO:0046887 positive regulation of hormone secretion 4/803 133/18722 0.827463422038662 0.888974924000166 CAMK2N1/GJA1/LRP1/ITSN1 4 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 3/803 104/18722 0.828876435790791 0.890301143656373 EDNRB/LPAR1/CMKLR1 3 GO:0099111 microtubule-based transport 6/803 190/18722 0.829371348731338 0.890491498107966 MAP1B/DST/PURA/ARHGAP21/ARMCX3/HSPB1 6 GO:0034250 positive regulation of cellular amide metabolic process 5/803 162/18722 0.829410853833413 0.890491498107966 THBS1/VIM/CLU/ROCK2/PLXNB2 5 GO:0008277 regulation of G protein-coupled receptor signaling pathway 4/803 134/18722 0.83181087367026 0.89268381750321 PRKCA/RAMP1/ROCK2/PLCB1 4 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 4/803 134/18722 0.83181087367026 0.89268381750321 PRICKLE1/CLU/DAB2/HECTD1 4 GO:0009201 ribonucleoside triphosphate biosynthetic process 2/803 74/18722 0.832198201976704 0.892715196870879 PID1/STAT3 2 GO:0010822 positive regulation of mitochondrion organization 2/803 74/18722 0.832198201976704 0.892715196870879 DCN/PLAUR 2 GO:0016079 synaptic vesicle exocytosis 3/803 105/18722 0.833709197786546 0.894143699755585 CASK/STX2/PREPL 3 GO:0007099 centriole replication 1/803 41/18722 0.834587241705294 0.894315922446292 CEP44 1 GO:0030488 tRNA methylation 1/803 41/18722 0.834587241705294 0.894315922446292 TRMT44 1 GO:0050892 intestinal absorption 1/803 41/18722 0.834587241705294 0.894315922446292 CD36 1 GO:1901385 regulation of voltage-gated calcium channel activity 1/803 41/18722 0.834587241705294 0.894315922446292 AHNAK 1 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 5/803 164/18722 0.837218812242352 0.896931954041274 PRICKLE1/PTEN/CLU/DAB2/HECTD1 5 GO:0002292 T cell differentiation involved in immune response 2/803 75/18722 0.837748116720861 0.896931954041274 TMEM98/STAT3 2 GO:0051453 regulation of intracellular pH 2/803 75/18722 0.837748116720861 0.896931954041274 SLC9A9/TMEM106B 2 GO:2001259 positive regulation of cation channel activity 2/803 75/18722 0.837748116720861 0.896931954041274 PKD2/IFNGR2 2 GO:0099024 plasma membrane invagination 4/803 136/18722 0.840232209199915 0.899036773247692 CD36/THBS1/MFGE8/GSN 4 GO:1903305 regulation of regulated secretory pathway 4/803 136/18722 0.840232209199915 0.899036773247692 CASK/HLA-F/PREPL/FER 4 GO:0000266 mitochondrial fission 1/803 42/18722 0.841697484460534 0.899036773247692 DCN 1 GO:0030890 positive regulation of B cell proliferation 1/803 42/18722 0.841697484460534 0.899036773247692 CD81 1 GO:0032467 positive regulation of cytokinesis 1/803 42/18722 0.841697484460534 0.899036773247692 CDC25B 1 GO:0033003 regulation of mast cell activation 1/803 42/18722 0.841697484460534 0.899036773247692 FER 1 GO:0051452 intracellular pH reduction 1/803 42/18722 0.841697484460534 0.899036773247692 TMEM106B 1 GO:0055090 acylglycerol homeostasis 1/803 42/18722 0.841697484460534 0.899036773247692 APOE 1 GO:0070328 triglyceride homeostasis 1/803 42/18722 0.841697484460534 0.899036773247692 APOE 1 GO:0071312 cellular response to alkaloid 1/803 42/18722 0.841697484460534 0.899036773247692 SLC8A1 1 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 1/803 42/18722 0.841697484460534 0.899036773247692 ATM 1 GO:0071868 cellular response to monoamine stimulus 3/803 107/18722 0.84302315271713 0.899989979390295 PALM/FLNA/ABL1 3 GO:0071870 cellular response to catecholamine stimulus 3/803 107/18722 0.84302315271713 0.899989979390295 PALM/FLNA/ABL1 3 GO:0009123 nucleoside monophosphate metabolic process 2/803 76/18722 0.843131406685132 0.899989979390295 CASK/MAGI3 2 GO:0046034 ATP metabolic process 9/803 277/18722 0.844713449458712 0.901485714683462 ENPP1/ATP1B1/FAM20C/TSPO/COX7A1/NUPR1/PID1/STAT3/PRKAA1 9 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 4/803 138/18722 0.848296949309874 0.902246376497012 ANGPT1/PRICKLE1/PTEN/NDFIP1 4 GO:0006367 transcription initiation from RNA polymerase II promoter 2/803 77/18722 0.848352133572287 0.902246376497012 THRA/MED13 2 GO:0034728 nucleosome organization 5/803 167/18722 0.848379681828615 0.902246376497012 KAT6B/RSF1/ATRX/SHPRH/BPTF 5 GO:0002861 regulation of inflammatory response to antigenic stimulus 1/803 43/18722 0.848502458763435 0.902246376497012 CD81 1 GO:0006284 base-excision repair 1/803 43/18722 0.848502458763435 0.902246376497012 USP47 1 GO:0006458 'de novo' protein folding 1/803 43/18722 0.848502458763435 0.902246376497012 HSPA2 1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1/803 43/18722 0.848502458763435 0.902246376497012 CDH11 1 GO:0033046 negative regulation of sister chromatid segregation 1/803 43/18722 0.848502458763435 0.902246376497012 ATM 1 GO:0033048 negative regulation of mitotic sister chromatid segregation 1/803 43/18722 0.848502458763435 0.902246376497012 ATM 1 GO:0034142 toll-like receptor 4 signaling pathway 1/803 43/18722 0.848502458763435 0.902246376497012 MFHAS1 1 GO:0034661 ncRNA catabolic process 1/803 43/18722 0.848502458763435 0.902246376497012 KCNQ1OT1 1 GO:0035794 positive regulation of mitochondrial membrane permeability 1/803 43/18722 0.848502458763435 0.902246376497012 BNIP3L 1 GO:0045494 photoreceptor cell maintenance 1/803 43/18722 0.848502458763435 0.902246376497012 PROM1 1 GO:0045776 negative regulation of blood pressure 1/803 43/18722 0.848502458763435 0.902246376497012 BMPR2 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/803 43/18722 0.848502458763435 0.902246376497012 TWSG1 1 GO:0098815 modulation of excitatory postsynaptic potential 1/803 43/18722 0.848502458763435 0.902246376497012 PTEN 1 GO:2000816 negative regulation of mitotic sister chromatid separation 1/803 43/18722 0.848502458763435 0.902246376497012 ATM 1 GO:1901616 organic hydroxy compound catabolic process 2/803 78/18722 0.853414317658771 0.907275860948109 APOE/PTEN 2 GO:0021517 ventral spinal cord development 1/803 44/18722 0.855015255252164 0.907429983543484 VLDLR 1 GO:0032620 interleukin-17 production 1/803 44/18722 0.855015255252164 0.907429983543484 PRNP 1 GO:0032660 regulation of interleukin-17 production 1/803 44/18722 0.855015255252164 0.907429983543484 PRNP 1 GO:0042554 superoxide anion generation 1/803 44/18722 0.855015255252164 0.907429983543484 SH3PXD2A 1 GO:0044058 regulation of digestive system process 1/803 44/18722 0.855015255252164 0.907429983543484 WNK1 1 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 1/803 44/18722 0.855015255252164 0.907429983543484 PRLR 1 GO:0089718 amino acid import across plasma membrane 1/803 44/18722 0.855015255252164 0.907429983543484 ITGB1 1 GO:0097178 ruffle assembly 1/803 44/18722 0.855015255252164 0.907429983543484 EPS8 1 GO:0002440 production of molecular mediator of immune response 10/803 308/18722 0.855438779350793 0.907663593702074 SPON2/CD36/IL1R1/ANGPT1/HLA-A/CD81/B2M/BST2/HLA-F/NDFIP1 10 GO:0009063 cellular amino acid catabolic process 3/803 110/18722 0.856145583871009 0.907663593702074 GLS/DDAH2/OAT 3 GO:0009408 response to heat 3/803 110/18722 0.856145583871009 0.907663593702074 THBS1/HSPA2/ATM 3 GO:0030317 flagellated sperm motility 3/803 110/18722 0.856145583871009 0.907663593702074 ADCY3/PLTP/ASH1L 3 GO:0097722 sperm motility 3/803 110/18722 0.856145583871009 0.907663593702074 ADCY3/PLTP/ASH1L 3 GO:0016241 regulation of macroautophagy 4/803 141/18722 0.859747314134269 0.910363481393996 DCN/SESN3/NUPR1/BNIP3L 4 GO:0071867 response to monoamine 3/803 111/18722 0.860301603588066 0.910363481393996 PALM/FLNA/ABL1 3 GO:0071869 response to catecholamine 3/803 111/18722 0.860301603588066 0.910363481393996 PALM/FLNA/ABL1 3 GO:0032259 methylation 12/803 364/18722 0.86068067982052 0.910363481393996 NNMT/INMT/PRDM6/MAEL/TRMT44/KMT2A/ASH1L/ATRX/RNMT/KMT2E/RTF1/ICMT 12 GO:0006903 vesicle targeting 1/803 45/18722 0.861248403877954 0.910363481393996 SAR1A 1 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 1/803 45/18722 0.861248403877954 0.910363481393996 HSPB1 1 GO:0010824 regulation of centrosome duplication 1/803 45/18722 0.861248403877954 0.910363481393996 ROCK2 1 GO:0045910 negative regulation of DNA recombination 1/803 45/18722 0.861248403877954 0.910363481393996 NDFIP1 1 GO:0045933 positive regulation of muscle contraction 1/803 45/18722 0.861248403877954 0.910363481393996 SPX 1 GO:0051985 negative regulation of chromosome segregation 1/803 45/18722 0.861248403877954 0.910363481393996 ATM 1 GO:0060119 inner ear receptor cell development 1/803 45/18722 0.861248403877954 0.910363481393996 CTHRC1 1 GO:0098534 centriole assembly 1/803 45/18722 0.861248403877954 0.910363481393996 CEP44 1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 1/803 45/18722 0.861248403877954 0.910363481393996 BNIP3L 1 GO:1905819 negative regulation of chromosome separation 1/803 45/18722 0.861248403877954 0.910363481393996 ATM 1 GO:0051303 establishment of chromosome localization 2/803 80/18722 0.863078908307423 0.912105009923869 EML4/TERF1 2 GO:0006403 RNA localization 6/803 201/18722 0.866288353721237 0.915302761528732 TGFBR2/ZFP36L1/SIDT2/MYO1C/TERF1/ATM 6 GO:0006383 transcription by RNA polymerase III 1/803 46/18722 0.867213897891233 0.915310858358528 SNAPC3 1 GO:0010830 regulation of myotube differentiation 1/803 46/18722 0.867213897891233 0.915310858358528 PIEZO1 1 GO:0033047 regulation of mitotic sister chromatid segregation 1/803 46/18722 0.867213897891233 0.915310858358528 ATM 1 GO:0045851 pH reduction 1/803 46/18722 0.867213897891233 0.915310858358528 TMEM106B 1 GO:0090329 regulation of DNA-dependent DNA replication 1/803 46/18722 0.867213897891233 0.915310858358528 ATRX 1 GO:0030641 regulation of cellular pH 2/803 81/18722 0.867689115058103 0.915424868319869 SLC9A9/TMEM106B 2 GO:0044773 mitotic DNA damage checkpoint signaling 2/803 81/18722 0.867689115058103 0.915424868319869 TAOK1/ATM 2 GO:0017157 regulation of exocytosis 6/803 202/18722 0.869289622512016 0.916919411433237 STXBP6/CASK/SDC1/HLA-F/PREPL/FER 6 GO:0044782 cilium organization 12/803 368/18722 0.86991192009827 0.917187742357787 EHD2/FLNA/SPATA6/RAB23/PKD2/YAP1/ASAP1/TTC17/CEP290/CCDC88A/GSN/TXNDC15 12 GO:0071692 protein localization to extracellular region 12/803 368/18722 0.86991192009827 0.917187742357787 LTBP2/APOE/CAMK2N1/GJA1/IRS1/LRP1/DPP4/FBN1/SIDT2/MAP4K4/CANX/CLOCK 12 GO:0010324 membrane invagination 4/803 144/18722 0.870452123652025 0.917563274530444 CD36/THBS1/MFGE8/GSN 4 GO:0050000 chromosome localization 2/803 82/18722 0.872156373495822 0.918808351061643 EML4/TERF1 2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 2/803 82/18722 0.872156373495822 0.918808351061643 RPP25/AGO3 2 GO:0010799 regulation of peptidyl-threonine phosphorylation 1/803 47/18722 0.872923216802849 0.918808351061643 SPRED1 1 GO:0045332 phospholipid translocation 1/803 47/18722 0.872923216802849 0.918808351061643 PLSCR4 1 GO:0046677 response to antibiotic 1/803 47/18722 0.872923216802849 0.918808351061643 JAK1 1 GO:0050885 neuromuscular process controlling balance 1/803 47/18722 0.872923216802849 0.918808351061643 ABL1 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/803 47/18722 0.872923216802849 0.918808351061643 THBS1 1 GO:0007269 neurotransmitter secretion 4/803 145/18722 0.873860712426425 0.919406944958463 CASK/STX2/PREPL/MCTP2 4 GO:0099643 signal release from synapse 4/803 145/18722 0.873860712426425 0.919406944958463 CASK/STX2/PREPL/MCTP2 4 GO:0000077 DNA damage checkpoint signaling 3/803 115/18722 0.875889266772575 0.921195498909422 TAOK1/ATM/CLOCK 3 GO:0001510 RNA methylation 2/803 83/18722 0.876484445813537 0.921195498909422 TRMT44/RNMT 2 GO:0031397 negative regulation of protein ubiquitination 2/803 83/18722 0.876484445813537 0.921195498909422 TSPO/ABL1 2 GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/803 83/18722 0.876484445813537 0.921195498909422 TMEM98/STAT3 2 GO:0050886 endocrine process 2/803 83/18722 0.876484445813537 0.921195498909422 GJA1/ECE1 2 GO:0006111 regulation of gluconeogenesis 1/803 48/18722 0.878387348364151 0.922417716710964 NNMT 1 GO:0035036 sperm-egg recognition 1/803 48/18722 0.878387348364151 0.922417716710964 CD9 1 GO:0044458 motile cilium assembly 1/803 48/18722 0.878387348364151 0.922417716710964 SPATA6 1 GO:1905710 positive regulation of membrane permeability 1/803 48/18722 0.878387348364151 0.922417716710964 BNIP3L 1 GO:0015980 energy derivation by oxidation of organic compounds 10/803 318/18722 0.879897286666884 0.923808774757019 ENPP1/IL6ST/IGF2/IRS1/COX7A1/NUPR1/PLEC/PID1/IFNAR1/RB1CC1 10 GO:0006835 dicarboxylic acid transport 2/803 84/18722 0.880677034905045 0.924432778112959 GJA1/ITGB1 2 GO:0002429 immune response-activating cell surface receptor signaling pathway 9/803 291/18722 0.881352648460873 0.924558027609071 THY1/CMKLR1/HLA-A/CD81/PRNP/CMTM3/ABL1/WNK1/BTN3A2 9 GO:0002757 immune response-activating signal transduction 9/803 291/18722 0.881352648460873 0.924558027609071 THY1/CMKLR1/HLA-A/CD81/PRNP/CMTM3/ABL1/WNK1/BTN3A2 9 GO:0016236 macroautophagy 9/803 291/18722 0.881352648460873 0.924558027609071 DCN/SYNPO2/RAB23/SESN3/NUPR1/BNIP3L/NBR1/STAM2/RB1CC1 9 GO:0051225 spindle assembly 3/803 117/18722 0.883089476121295 0.924598827430096 FLNA/MAP9/NEK7 3 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 1/803 49/18722 0.883616809607783 0.924598827430096 NDFIP1 1 GO:0002208 somatic diversification of immunoglobulins involved in immune response 1/803 49/18722 0.883616809607783 0.924598827430096 NDFIP1 1 GO:0009066 aspartate family amino acid metabolic process 1/803 49/18722 0.883616809607783 0.924598827430096 PLOD2 1 GO:0009395 phospholipid catabolic process 1/803 49/18722 0.883616809607783 0.924598827430096 ENPP2 1 GO:0018198 peptidyl-cysteine modification 1/803 49/18722 0.883616809607783 0.924598827430096 ZDHHC21 1 GO:0032692 negative regulation of interleukin-1 production 1/803 49/18722 0.883616809607783 0.924598827430096 GAS6 1 GO:0045190 isotype switching 1/803 49/18722 0.883616809607783 0.924598827430096 NDFIP1 1 GO:0046605 regulation of centrosome cycle 1/803 49/18722 0.883616809607783 0.924598827430096 ROCK2 1 GO:0051932 synaptic transmission, GABAergic 1/803 49/18722 0.883616809607783 0.924598827430096 PTEN 1 GO:0060986 endocrine hormone secretion 1/803 49/18722 0.883616809607783 0.924598827430096 GJA1 1 GO:1904894 positive regulation of receptor signaling pathway via STAT 1/803 49/18722 0.883616809607783 0.924598827430096 PRLR 1 GO:0009142 nucleoside triphosphate biosynthetic process 2/803 85/18722 0.884737782526835 0.925189300268205 PID1/STAT3 2 GO:0044774 mitotic DNA integrity checkpoint signaling 2/803 85/18722 0.884737782526835 0.925189300268205 TAOK1/ATM 2 GO:2000779 regulation of double-strand break repair 2/803 85/18722 0.884737782526835 0.925189300268205 TWIST1/RNF169 2 GO:0007080 mitotic metaphase plate congression 1/803 50/18722 0.888621666989294 0.92735662513245 EML4 1 GO:0008089 anterograde axonal transport 1/803 50/18722 0.888621666989294 0.92735662513245 HSPB1 1 GO:0015872 dopamine transport 1/803 50/18722 0.888621666989294 0.92735662513245 SLC22A3 1 GO:0042572 retinol metabolic process 1/803 50/18722 0.888621666989294 0.92735662513245 RDH10 1 GO:0045058 T cell selection 1/803 50/18722 0.888621666989294 0.92735662513245 STAT3 1 GO:0046638 positive regulation of alpha-beta T cell differentiation 1/803 50/18722 0.888621666989294 0.92735662513245 TGFBR2 1 GO:0050873 brown fat cell differentiation 1/803 50/18722 0.888621666989294 0.92735662513245 METRNL 1 GO:0070231 T cell apoptotic process 1/803 50/18722 0.888621666989294 0.92735662513245 BMP4 1 GO:1901570 fatty acid derivative biosynthetic process 1/803 50/18722 0.888621666989294 0.92735662513245 ELOVL2 1 GO:0045921 positive regulation of exocytosis 2/803 86/18722 0.888670267726203 0.92735662513245 SDC1/HLA-F 2 GO:0031396 regulation of protein ubiquitination 6/803 210/18722 0.891332502308512 0.92994012481905 ANGPT1/PRICKLE1/PTEN/TSPO/ABL1/NDFIP1 6 GO:0031497 chromatin assembly 4/803 151/18722 0.89272593453386 0.931199060582808 KAT6B/RSF1/ATRX/SHPRH 4 GO:1903307 positive regulation of regulated secretory pathway 1/803 51/18722 0.893411555667935 0.931719309048384 HLA-F 1 GO:0006887 exocytosis 11/803 352/18722 0.893629333083103 0.931751538007602 PTGDS/STXBP6/SCRN1/CASK/STX2/SDC1/HLA-F/PREPL/FER/TNFAIP2/ITSN1 11 GO:0023061 signal release 15/803 463/18722 0.897563953058611 0.935521636031241 SLC16A10/LTBP4/CAMK2N1/GJA1/CASK/IRS1/LRP1/DPP4/STX2/SIDT2/PREPL/MCTP2/MAP4K4/ITSN1/CLOCK 15 GO:0002218 activation of innate immune response 1/803 52/18722 0.897995697963401 0.935521636031241 IFI16 1 GO:0034204 lipid translocation 1/803 52/18722 0.897995697963401 0.935521636031241 PLSCR4 1 GO:0043090 amino acid import 1/803 52/18722 0.897995697963401 0.935521636031241 ITGB1 1 GO:0051168 nuclear export 4/803 154/18722 0.901196544485719 0.938660115062836 GAS6/PKD1/ATXN1/AKAP13 4 GO:0032784 regulation of DNA-templated transcription, elongation 1/803 53/18722 0.902382921023679 0.939042454477278 ZMYND11 1 GO:0045806 negative regulation of endocytosis 1/803 53/18722 0.902382921023679 0.939042454477278 EPHA3 1 GO:0097479 synaptic vesicle localization 1/803 53/18722 0.902382921023679 0.939042454477278 PTEN 1 GO:0006690 icosanoid metabolic process 3/803 123/18722 0.90250530322004 0.939042454477278 PTGDS/ZADH2/TNFRSF1A 3 GO:0031570 DNA integrity checkpoint signaling 3/803 123/18722 0.90250530322004 0.939042454477278 TAOK1/ATM/CLOCK 3 GO:0006400 tRNA modification 2/803 90/18722 0.903186902486786 0.939555580179244 TRMT44/DTWD1 2 GO:0002275 myeloid cell activation involved in immune response 2/803 91/18722 0.906529486040327 0.942442872684961 PTGDS/FER 2 GO:0051983 regulation of chromosome segregation 2/803 91/18722 0.906529486040327 0.942442872684961 PUM2/ATM 2 GO:0098661 inorganic anion transmembrane transport 2/803 91/18722 0.906529486040327 0.942442872684961 APOL1/PRNP 2 GO:0009306 protein secretion 11/803 359/18722 0.906743398282944 0.942468747933866 LTBP2/APOE/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/CANX/CLOCK 11 GO:0060294 cilium movement involved in cell motility 3/803 125/18722 0.90830010216642 0.943890018633133 ADCY3/PLTP/ASH1L 3 GO:0035592 establishment of protein localization to extracellular region 11/803 360/18722 0.908502153849391 0.94390325882331 LTBP2/APOE/CAMK2N1/GJA1/IRS1/LRP1/DPP4/SIDT2/MAP4K4/CANX/CLOCK 11 GO:0070646 protein modification by small protein removal 4/803 157/18722 0.909071422397905 0.944297940015824 COPS8/USP11/USP47/USP9X 4 GO:0034502 protein localization to chromosome 2/803 92/18722 0.909763905432813 0.944623663575178 ATRX/TERF1 2 GO:0035249 synaptic transmission, glutamatergic 2/803 92/18722 0.909763905432813 0.944623663575178 SERPINE2/EXT1 2 GO:0006360 transcription by RNA polymerase I 1/803 55/18722 0.910600042925003 0.945098212744393 FLNA 1 GO:0006414 translational elongation 1/803 55/18722 0.910600042925003 0.945098212744393 LTN1 1 GO:0032088 negative regulation of NF-kappaB transcription factor activity 2/803 93/18722 0.912893275306569 0.947281138538721 CMKLR1/KLF4 2 GO:0007281 germ cell development 8/803 278/18722 0.913519260882647 0.947314897860609 PDE3A/BMP4/HSPA2/SMAD5/MDK/CDC25B/FNDC3A/FOXO3 8 GO:0008033 tRNA processing 3/803 127/18722 0.913781069970238 0.947314897860609 RPP25/TRMT44/DTWD1 3 GO:0032200 telomere organization 4/803 159/18722 0.914006907347976 0.947314897860609 ATRX/TERF1/NEK7/ATM 4 GO:0002886 regulation of myeloid leukocyte mediated immunity 1/803 56/18722 0.914445768833355 0.947314897860609 FER 1 GO:0006687 glycosphingolipid metabolic process 1/803 56/18722 0.914445768833355 0.947314897860609 PRKAA1 1 GO:0046456 icosanoid biosynthetic process 1/803 56/18722 0.914445768833355 0.947314897860609 PTGDS 1 GO:0070534 protein K63-linked ubiquitination 1/803 56/18722 0.914445768833355 0.947314897860609 HECTD1 1 GO:0098781 ncRNA transcription 1/803 56/18722 0.914445768833355 0.947314897860609 SNAPC3 1 GO:0060271 cilium assembly 10/803 337/18722 0.917070899411684 0.949837038734245 EHD2/FLNA/SPATA6/RAB23/YAP1/ASAP1/CEP290/CCDC88A/GSN/TXNDC15 10 GO:0006302 double-strand break repair 7/803 251/18722 0.917349359146315 0.949928121433754 REV3L/TWIST1/SETX/RNF169/RECQL/ATM/NUCKS1 7 GO:0016447 somatic recombination of immunoglobulin gene segments 1/803 57/18722 0.918126259973761 0.950337872582349 NDFIP1 1 GO:0030219 megakaryocyte differentiation 1/803 57/18722 0.918126259973761 0.950337872582349 SP3 1 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 2/803 95/18722 0.918848986158898 0.950888552301425 TSPO/ABL1 2 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 3/803 130/18722 0.921445242967221 0.952041133683887 GAS1/SEC31A/SAR1A 3 GO:0007131 reciprocal meiotic recombination 1/803 58/18722 0.92164860732126 0.952041133683887 ATM 1 GO:0031424 keratinization 1/803 58/18722 0.92164860732126 0.952041133683887 PPL 1 GO:0042743 hydrogen peroxide metabolic process 1/803 58/18722 0.92164860732126 0.952041133683887 STAT3 1 GO:0097035 regulation of membrane lipid distribution 1/803 58/18722 0.92164860732126 0.952041133683887 PLSCR4 1 GO:0140527 reciprocal homologous recombination 1/803 58/18722 0.92164860732126 0.952041133683887 ATM 1 GO:0006637 acyl-CoA metabolic process 2/803 96/18722 0.921681217868456 0.952041133683887 ELOVL2/PDK4 2 GO:0035383 thioester metabolic process 2/803 96/18722 0.921681217868456 0.952041133683887 ELOVL2/PDK4 2 GO:0042158 lipoprotein biosynthetic process 2/803 96/18722 0.921681217868456 0.952041133683887 APOE/ZDHHC21 2 GO:0050657 nucleic acid transport 4/803 163/18722 0.92316676314753 0.95298332941068 TGFBR2/ZFP36L1/SIDT2/MYO1C 4 GO:0050658 RNA transport 4/803 163/18722 0.92316676314753 0.95298332941068 TGFBR2/ZFP36L1/SIDT2/MYO1C 4 GO:0061025 membrane fusion 4/803 163/18722 0.92316676314753 0.95298332941068 STXBP6/GAS6/CD9/STX2 4 GO:0050853 B cell receptor signaling pathway 3/803 131/18722 0.923858280525716 0.95349976955107 CD81/CMTM3/ABL1 3 GO:0019369 arachidonic acid metabolic process 1/803 59/18722 0.925019597908542 0.954105857503515 PTGDS 1 GO:0048278 vesicle docking 1/803 59/18722 0.925019597908542 0.954105857503515 STX2 1 GO:2001258 negative regulation of cation channel activity 1/803 59/18722 0.925019597908542 0.954105857503515 PKD2 1 GO:0071826 ribonucleoprotein complex subunit organization 6/803 227/18722 0.927854344305613 0.95664183526289 CELF2/AGO3/SETX/LUC7L3/KLC1/ATM 6 GO:0002712 regulation of B cell mediated immunity 1/803 60/18722 0.92824572783832 0.95664183526289 NDFIP1 1 GO:0002889 regulation of immunoglobulin mediated immune response 1/803 60/18722 0.92824572783832 0.95664183526289 NDFIP1 1 GO:0030071 regulation of mitotic metaphase/anaphase transition 1/803 60/18722 0.92824572783832 0.95664183526289 ATM 1 GO:0050864 regulation of B cell activation 5/803 198/18722 0.930621100067162 0.958891672852835 CD81/ZFP36L2/ZFP36L1/ATM/NDFIP1 5 GO:0007059 chromosome segregation 10/803 346/18722 0.930961821935258 0.959030856813317 MAEL/NR3C1/PDS5B/ATRX/EML4/P3H4/PUM2/TERF1/ATM/USP9X 10 GO:0042255 ribosome assembly 1/803 61/18722 0.931333214739286 0.959030856813317 SBDS 1 GO:1905515 non-motile cilium assembly 1/803 61/18722 0.931333214739286 0.959030856813317 CEP290 1 GO:0045055 regulated exocytosis 6/803 230/18722 0.93303755351956 0.960542905274347 PTGDS/CASK/STX2/HLA-F/PREPL/FER 6 GO:0000070 mitotic sister chromatid segregation 4/803 168/18722 0.93337953791701 0.960542905274347 PDS5B/ATRX/EML4/ATM 4 GO:0002833 positive regulation of response to biotic stimulus 4/803 168/18722 0.93337953791701 0.960542905274347 PRKCA/HLA-F/IFI16/PUM2 4 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 1/803 62/18722 0.934288009689415 0.960684680616915 ATM 1 GO:0031124 mRNA 3'-end processing 1/803 62/18722 0.934288009689415 0.960684680616915 ZFP36L1 1 GO:0046173 polyol biosynthetic process 1/803 62/18722 0.934288009689415 0.960684680616915 IPMK 1 GO:0048663 neuron fate commitment 1/803 62/18722 0.934288009689415 0.960684680616915 BMP4 1 GO:0045727 positive regulation of translation 3/803 136/18722 0.934935436137663 0.961152182388121 THBS1/VIM/PLXNB2 3 GO:0006091 generation of precursor metabolites and energy 15/803 490/18722 0.935641817946385 0.961481884641524 ENPP1/IL6ST/STEAP4/P4HA2/IGF2/IRS1/COX7A1/NUPR1/H6PD/PLEC/PID1/STAT3/PRKAA1/IFNAR1/RB1CC1 15 GO:0010498 proteasomal protein catabolic process 15/803 490/18722 0.935641817946385 0.961481884641524 APOE/MAN1A1/PRICKLE1/LTN1/PKD1/CLU/NUPR1/KCTD2/HSP90B1/TBL1XR1/DAB2/AMFR/HECTD1/CANX/CLOCK 15 GO:0034655 nucleobase-containing compound catabolic process 12/803 407/18722 0.936547239280708 0.96221399856864 ENPP1/PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 12 GO:0050714 positive regulation of protein secretion 3/803 137/18722 0.936964396622663 0.962401528697424 CAMK2N1/GJA1/LRP1 3 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 1/803 63/18722 0.937115808629361 0.962401528697424 ATM 1 GO:0000724 double-strand break repair via homologous recombination 3/803 138/18722 0.938934784340725 0.963523460750438 REV3L/RECQL/NUCKS1 3 GO:0001539 cilium or flagellum-dependent cell motility 3/803 138/18722 0.938934784340725 0.963523460750438 ADCY3/PLTP/ASH1L 3 GO:0060285 cilium-dependent cell motility 3/803 138/18722 0.938934784340725 0.963523460750438 ADCY3/PLTP/ASH1L 3 GO:0006325 chromatin organization 12/803 409/18722 0.93898124664789 0.963523460750438 MLLT3/CHD9/KAT6B/NR3C1/HCFC2/RSF1/ATRX/SHPRH/ZMYND11/KMT2E/NUCKS1/BPTF 12 GO:0016579 protein deubiquitination 3/803 139/18722 0.940848080160724 0.9649305532629 USP11/USP47/USP9X 3 GO:0022600 digestive system process 2/803 104/18722 0.941206476785742 0.9649305532629 CD36/WNK1 2 GO:0006487 protein N-linked glycosylation 1/803 65/18722 0.942411991639111 0.9649305532629 PGM3 1 GO:0010965 regulation of mitotic sister chromatid separation 1/803 65/18722 0.942411991639111 0.9649305532629 ATM 1 GO:0044784 metaphase/anaphase transition of cell cycle 1/803 65/18722 0.942411991639111 0.9649305532629 ATM 1 GO:0046503 glycerolipid catabolic process 1/803 65/18722 0.942411991639111 0.9649305532629 ENPP2 1 GO:0051310 metaphase plate congression 1/803 65/18722 0.942411991639111 0.9649305532629 EML4 1 GO:0061512 protein localization to cilium 1/803 65/18722 0.942411991639111 0.9649305532629 CCDC88A 1 GO:1902475 L-alpha-amino acid transmembrane transport 1/803 65/18722 0.942411991639111 0.9649305532629 ITGB1 1 GO:0000209 protein polyubiquitination 6/803 236/18722 0.942424837489448 0.9649305532629 TTC3/NPEPPS/AMFR/SHPRH/HECTD1/LNPEP 6 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 12/803 412/18722 0.942481306536366 0.9649305532629 MAN1A1/PRICKLE1/LTN1/CLU/KCTD2/HSP90B1/TBL1XR1/DAB2/AMFR/HECTD1/CANX/CLOCK 12 GO:0000725 recombinational repair 3/803 140/18722 0.942705737284679 0.964962185608993 REV3L/RECQL/NUCKS1 3 GO:0048284 organelle fusion 3/803 141/18722 0.944509181266209 0.966008708497586 STXBP6/STX2/PID1 3 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 1/803 66/18722 0.944890587914707 0.966008708497586 NDFIP1 1 GO:0006303 double-strand break repair via nonhomologous end joining 1/803 66/18722 0.944890587914707 0.966008708497586 ATM 1 GO:0016444 somatic cell DNA recombination 1/803 66/18722 0.944890587914707 0.966008708497586 NDFIP1 1 GO:0050909 sensory perception of taste 1/803 66/18722 0.944890587914707 0.966008708497586 CD36 1 GO:1902476 chloride transmembrane transport 1/803 66/18722 0.944890587914707 0.966008708497586 APOL1 1 GO:0006906 vesicle fusion 2/803 106/18722 0.945310527709626 0.966239912086961 STXBP6/STX2 2 GO:0022900 electron transport chain 4/803 175/18722 0.945616055116195 0.96635409936654 STEAP4/P4HA2/COX7A1/PLEC 4 GO:0016445 somatic diversification of immunoglobulins 1/803 67/18722 0.947262632184888 0.967640131955306 NDFIP1 1 GO:0051306 mitotic sister chromatid separation 1/803 67/18722 0.947262632184888 0.967640131955306 ATM 1 GO:0006333 chromatin assembly or disassembly 4/803 177/18722 0.948714178499996 0.968768168583028 KAT6B/RSF1/ATRX/SHPRH 4 GO:0033138 positive regulation of peptidyl-serine phosphorylation 2/803 108/18722 0.949140942866325 0.968768168583028 GAS6/ANGPT1 2 GO:0140053 mitochondrial gene expression 2/803 108/18722 0.949140942866325 0.968768168583028 FOXO3/PRKAA1 2 GO:0009247 glycolipid biosynthetic process 1/803 68/18722 0.94953269953174 0.968768168583028 PRKAA1 1 GO:0046637 regulation of alpha-beta T cell differentiation 1/803 68/18722 0.94953269953174 0.968768168583028 TGFBR2 1 GO:0061912 selective autophagy 1/803 68/18722 0.94953269953174 0.968768168583028 RB1CC1 1 GO:0051966 regulation of synaptic transmission, glutamatergic 1/803 69/18722 0.951705168829264 0.970786000773877 SERPINE2 1 GO:0090174 organelle membrane fusion 2/803 110/18722 0.952714671229134 0.97161696681294 STXBP6/STX2 2 GO:0002548 monocyte chemotaxis 1/803 70/18722 0.953784231147931 0.972508829550836 SLIT2 1 GO:0098656 anion transmembrane transport 6/803 245/18722 0.954309681602085 0.972845649656103 GJA1/SLC16A7/SLC9A9/APOL1/PRNP/ITGB1 6 GO:0001676 long-chain fatty acid metabolic process 2/803 112/18722 0.956047748739598 0.974418249226418 PTGDS/ELOVL2 2 GO:0033045 regulation of sister chromatid segregation 1/803 72/18722 0.95767800803863 0.975680945664203 ATM 1 GO:1905818 regulation of chromosome separation 1/803 72/18722 0.95767800803863 0.975680945664203 ATM 1 GO:0051047 positive regulation of secretion 8/803 310/18722 0.958281161089491 0.97609598962047 EDNRB/CAMK2N1/GJA1/LRP1/SDC1/HLA-F/PLA2R1/ITSN1 8 GO:0022904 respiratory electron transport chain 2/803 114/18722 0.959155331947438 0.976539738487908 COX7A1/PLEC 2 GO:0002637 regulation of immunoglobulin production 1/803 73/18722 0.959500236432463 0.976539738487908 NDFIP1 1 GO:0051937 catecholamine transport 1/803 73/18722 0.959500236432463 0.976539738487908 SLC22A3 1 GO:0070988 demethylation 1/803 73/18722 0.959500236432463 0.976539738487908 USP9X 1 GO:0098813 nuclear chromosome segregation 7/803 281/18722 0.959784371840179 0.976629566937782 MAEL/PDS5B/ATRX/EML4/P3H4/TERF1/ATM 7 GO:0043279 response to alkaloid 2/803 115/18722 0.96062906761425 0.977289641119088 PRKAA1/SLC8A1 2 GO:1901568 fatty acid derivative metabolic process 1/803 74/18722 0.961244099918158 0.977715847040379 ELOVL2 1 GO:0033044 regulation of chromosome organization 4/803 187/18722 0.961911558385625 0.977938825271452 ATRX/TERF1/NEK7/ATM 4 GO:0022618 ribonucleoprotein complex assembly 5/803 220/18722 0.961944933070292 0.977938825271452 CELF2/AGO3/SETX/LUC7L3/ATM 5 GO:0007006 mitochondrial membrane organization 2/803 116/18722 0.962051732442132 0.977938825271452 STAT3/BNIP3L 2 GO:0006520 cellular amino acid metabolic process 7/803 284/18722 0.962697939501785 0.978215982330076 PLOD2/GLS/SERINC3/DDAH2/SERINC5/GCLM/OAT 7 GO:0006094 gluconeogenesis 1/803 75/18722 0.96291296455596 0.978215982330076 NNMT 1 GO:1903363 negative regulation of cellular protein catabolic process 1/803 75/18722 0.96291296455596 0.978215982330076 LAPTM4B 1 GO:0044282 small molecule catabolic process 10/803 376/18722 0.963776398842104 0.978893690084892 CRABP1/APOE/BDH2/IRS1/PTEN/GLS/TWIST1/LPIN1/DDAH2/OAT 10 GO:0015931 nucleobase-containing compound transport 5/803 222/18722 0.964025695919465 0.978947478585428 GJA1/TGFBR2/ZFP36L1/SIDT2/MYO1C 5 GO:0140029 exocytic process 1/803 76/18722 0.964510051994237 0.979016703402172 STX2 1 GO:0046434 organophosphate catabolic process 3/803 155/18722 0.964798479161828 0.979016703402172 ENPP1/ENPP2/PTEN 3 GO:0006338 chromatin remodeling 6/803 255/18722 0.964879278082285 0.979016703402172 KAT6B/HCFC2/RSF1/ATRX/SHPRH/BPTF 6 GO:0043547 positive regulation of GTPase activity 6/803 255/18722 0.964879278082285 0.979016703402172 THY1/CHN1/ITGB1/ASAP1/EVI5/MAP4K4 6 GO:0002200 somatic diversification of immune receptors 1/803 77/18722 0.966038445657684 0.979993426256198 NDFIP1 1 GO:0007030 Golgi organization 3/803 157/18722 0.967049235489991 0.9808192612191 SYNE1/ARHGAP21/ATL3 3 GO:0019319 hexose biosynthetic process 1/803 78/18722 0.967501096670657 0.981077988204168 NNMT 1 GO:0007018 microtubule-based movement 10/803 382/18722 0.968346850373166 0.981735948751648 MAP1B/ADCY3/DST/PLTP/DYNLT3/ASH1L/PURA/ARHGAP21/ARMCX3/HSPB1 10 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 1/803 79/18722 0.968900829526989 0.982097893072082 CXCL14 1 GO:0046700 heterocycle catabolic process 12/803 445/18722 0.97086312811324 0.983886901783051 ENPP1/PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 12 GO:0046364 monosaccharide biosynthetic process 1/803 82/18722 0.972748976989849 0.98539748055087 NNMT 1 GO:0072527 pyrimidine-containing compound metabolic process 1/803 82/18722 0.972748976989849 0.98539748055087 SLC19A3 1 GO:0006323 DNA packaging 4/803 199/18722 0.973577608403264 0.986036554031825 KAT6B/RSF1/ATRX/SHPRH 4 GO:1901292 nucleoside phosphate catabolic process 1/803 83/18722 0.973922934687121 0.986185977325342 ENPP1 1 GO:0044270 cellular nitrogen compound catabolic process 12/803 451/18722 0.974398472126711 0.986467163862697 ENPP1/PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 12 GO:0009953 dorsal/ventral pattern formation 1/803 84/18722 0.975046379262808 0.986722396388139 BMP4 1 GO:0015844 monoamine transport 1/803 84/18722 0.975046379262808 0.986722396388139 SLC22A3 1 GO:0000819 sister chromatid segregation 4/803 202/18722 0.975919444279385 0.987405509167414 PDS5B/ATRX/EML4/ATM 4 GO:0009451 RNA modification 3/803 167/18722 0.976405368526255 0.987685688463297 TRMT44/DTWD1/RNMT 3 GO:0007093 mitotic cell cycle checkpoint signaling 2/803 129/18722 0.976592547959096 0.987685688463297 TAOK1/ATM 2 GO:0006282 regulation of DNA repair 2/803 130/18722 0.977454224599594 0.988156278153604 TWIST1/RNF169 2 GO:0051028 mRNA transport 2/803 130/18722 0.977454224599594 0.988156278153604 ZFP36L1/MYO1C 2 GO:0000075 cell cycle checkpoint signaling 3/803 169/18722 0.977945232744157 0.98839510739052 TAOK1/ATM/CLOCK 3 GO:0019646 aerobic electron transport chain 1/803 87/18722 0.978134881204764 0.98839510739052 COX7A1 1 GO:0045089 positive regulation of innate immune response 2/803 131/18722 0.978285169468956 0.98839510739052 HLA-F/IFI16 2 GO:0050829 defense response to Gram-negative bacterium 1/803 88/18722 0.979077070117701 0.988794464575017 RARRES2 1 GO:1901657 glycosyl compound metabolic process 1/803 88/18722 0.979077070117701 0.988794464575017 FUCA2 1 GO:0008380 RNA splicing 11/803 434/18722 0.980801627194417 0.990335543376137 SON/PIK3R1/CELF2/AHNAK/DDX17/SLC38A2/MBNL2/ZNF638/SETX/LUC7L3/ZRANB2 11 GO:1901361 organic cyclic compound catabolic process 13/803 495/18722 0.981266219850837 0.990604043769239 ENPP1/APOE/PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 13 GO:0051952 regulation of amine transport 1/803 91/18722 0.981667226316396 0.990756059477039 ITGB1 1 GO:0003341 cilium movement 3/803 175/18722 0.982011132589172 0.990756059477039 ADCY3/PLTP/ASH1L 3 GO:0019439 aromatic compound catabolic process 12/803 467/18722 0.982012925378164 0.990756059477039 ENPP1/PRKCA/KCNQ1OT1/TNRC6C/VIM/ROCK2/ZFP36L2/ZFP36L1/AGO3/SIDT2/PUM2/ATM 12 GO:0006497 protein lipidation 1/803 92/18722 0.982457372699732 0.991003936937257 ZDHHC21 1 GO:0007586 digestion 2/803 137/18722 0.982681819519269 0.991029844685088 CD36/WNK1 2 GO:1903532 positive regulation of secretion by cell 6/803 282/18722 0.983244559058781 0.991396839528227 CAMK2N1/GJA1/LRP1/SDC1/HLA-F/ITSN1 6 GO:0006399 tRNA metabolic process 3/803 179/18722 0.98431263332834 0.991990853999963 RPP25/TRMT44/DTWD1 3 GO:0042742 defense response to bacterium 8/803 350/18722 0.984577103004384 0.991990853999963 RARRES2/PLA2G2A/ADAMTS5/SPON2/CD36/HLA-A/TNFRSF1A/NOTCH2 8 GO:0042773 ATP synthesis coupled electron transport 1/803 95/18722 0.984629509916931 0.991990853999963 COX7A1 1 GO:0042775 mitochondrial ATP synthesis coupled electron transport 1/803 95/18722 0.984629509916931 0.991990853999963 COX7A1 1 GO:0006119 oxidative phosphorylation 2/803 141/18722 0.985118961113514 0.992257428369614 COX7A1/NUPR1 2 GO:0051304 chromosome separation 1/803 96/18722 0.985292123517441 0.992257428369614 ATM 1 GO:0006839 mitochondrial transport 5/803 254/18722 0.985836902860186 0.992605573033297 TSPO/NPEPPS/STAT3/PRKAA1/BNIP3L 5 GO:0015837 amine transport 1/803 99/18722 0.987113634429049 0.993690406069703 ITGB1 1 GO:0006664 glycolipid metabolic process 1/803 100/18722 0.987669278071506 0.993848440053386 PRKAA1 1 GO:0060079 excitatory postsynaptic potential 1/803 100/18722 0.987669278071506 0.993848440053386 PTEN 1 GO:1903509 liposaccharide metabolic process 1/803 101/18722 0.988200991620458 0.994182837816708 PRKAA1 1 GO:0090305 nucleic acid phosphodiester bond hydrolysis 5/803 261/18722 0.988535159597883 0.994188398826368 ENPP1/ENPP2/RPP25/AGO3/PLD3 5 GO:0050905 neuromuscular process 2/803 148/18722 0.98860531114744 0.994188398826368 PTEN/ABL1 2 GO:0045333 cellular respiration 4/803 230/18722 0.990111604498465 0.995326107529116 COX7A1/NUPR1/PLEC/IFNAR1 4 GO:0090501 RNA phosphodiester bond hydrolysis 2/803 152/18722 0.990225383010022 0.995326107529116 RPP25/AGO3 2 GO:0007218 neuropeptide signaling pathway 1/803 106/18722 0.990535127468807 0.995326107529116 SORT1 1 GO:0099565 chemical synaptic transmission, postsynaptic 1/803 106/18722 0.990535127468807 0.995326107529116 PTEN 1 GO:0000018 regulation of DNA recombination 1/803 107/18722 0.990943394155665 0.995535716957515 NDFIP1 1 GO:0006310 DNA recombination 6/803 305/18722 0.991347592632396 0.995741155694022 REV3L/SETX/RECQL/ATM/NUCKS1/NDFIP1 6 GO:0006805 xenobiotic metabolic process 1/803 111/18722 0.992407973082424 0.996605469041081 GSTM3 1 GO:0001578 microtubule bundle formation 1/803 113/18722 0.993048995612264 0.997048387459273 MAP1B 1 GO:0090630 activation of GTPase activity 1/803 115/18722 0.99363595595889 0.997436858548626 EVI5 1 GO:0031123 RNA 3'-end processing 1/803 116/18722 0.993910601380775 0.997452707338703 ZFP36L1 1 GO:0007286 spermatid development 2/803 165/18722 0.99408443167633 0.997452707338703 HSPA2/FNDC3A 2 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6/803 320/18722 0.994451947087985 0.997452707338703 SON/CELF2/DDX17/MBNL2/SETX/LUC7L3 6 GO:0000398 mRNA splicing, via spliceosome 6/803 320/18722 0.994451947087985 0.997452707338703 SON/CELF2/DDX17/MBNL2/SETX/LUC7L3 6 GO:0000375 RNA splicing, via transesterification reactions 6/803 324/18722 0.995080104307885 0.997882019324037 SON/CELF2/DDX17/MBNL2/SETX/LUC7L3 6 GO:0048515 spermatid differentiation 2/803 172/18722 0.99549602502635 0.997897704218211 HSPA2/FNDC3A 2 GO:1901136 carbohydrate derivative catabolic process 2/803 172/18722 0.99549602502635 0.997897704218211 MAN1A1/FUCA2 2 GO:0006364 rRNA processing 3/803 225/18722 0.996912989652782 0.999117219378648 RPP25/DDX17/SBDS 3 GO:0060078 regulation of postsynaptic membrane potential 1/803 137/18722 0.99759011218454 0.999412184854294 PTEN 1 GO:0009060 aerobic respiration 2/803 189/18722 0.99769025325222 0.999412184854294 COX7A1/NUPR1 2 GO:0016072 rRNA metabolic process 3/803 236/18722 0.997931993455927 0.999412184854294 RPP25/DDX17/SBDS 3 GO:0022613 ribonucleoprotein complex biogenesis 9/803 463/18722 0.998243918892685 0.999412184854294 RPP25/PTEN/CELF2/AGO3/DDX17/SETX/SBDS/LUC7L3/ATM 9 GO:0034470 ncRNA processing 7/803 395/18722 0.998321230462804 0.999412184854294 RPP25/TRMT44/DTWD1/AGO3/DDX17/SBDS/STAT3 7 GO:0002181 cytoplasmic translation 1/803 148/18722 0.99851769624138 0.999412184854294 EIF4A2 1 GO:0050871 positive regulation of B cell activation 1/803 152/18722 0.998757899969405 0.999412184854294 CD81 1 GO:0042254 ribosome biogenesis 4/803 299/18722 0.999047197352717 0.999412184854294 RPP25/PTEN/DDX17/SBDS 4 GO:0034660 ncRNA metabolic process 9/803 485/18722 0.999064534214503 0.999412184854294 MAEL/RPP25/KCNQ1OT1/TRMT44/DTWD1/AGO3/DDX17/SBDS/STAT3 9 GO:0002377 immunoglobulin production 2/803 216/18722 0.999211741175021 0.999412184854294 B2M/NDFIP1 2 GO:0007608 sensory perception of smell 2/803 456/18722 0.999999964472414 0.999999964472414 ADCY3/NAV2 2