ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0005201	extracellular matrix structural constituent	54/510	172/18367	5.55290435279497e-42	3.62604654237512e-39	COL1A2/COL3A1/COL1A1/DCN/COL6A1/LUM/IGFBP7/SPARC/COL6A2/COL6A3/MGP/THBS1/NID1/COL5A1/PXDN/LAMA4/AEBP1/LAMA2/OGN/LTBP2/MFGE8/SBSPON/NID2/ELN/PCOLCE/COL18A1/PRELP/CTHRC1/EDIL3/COL5A3/MATN2/COL12A1/EFEMP2/EMILIN1/COL5A2/LTBP4/VCAN/COL27A1/FBLN2/COL15A1/COL4A1/COL8A1/FBLN5/COL4A2/BGN/HSPG2/EMILIN2/LAMC1/LTBP1/FBN1/LAMB2/COL14A1/LAMB1/TGFBI	54
GO:0003779	actin binding	57/510	440/18367	1.57758268062292e-22	5.15080745223382e-20	TAGLN/TPM2/SYNPO2/MYLK/MYH11/MAP1B/LMOD1/PLS3/ANTXR1/PDLIM3/CNN1/PLEKHH2/MYO1B/FLNA/NEXN/TPM1/LASP1/CALD1/PDLIM7/MARCKS/HIP1/TNS1/PDLIM5/VCL/EPB41L2/ITGB1/PALLD/TMSB4X/TPM4/MARCKSL1/MYH9/EPS8/SYNE1/SPTBN1/LIMA1/ENAH/DST/SNTB2/ACTN4/CNN2/GSN/DSTN/CFL2/ACTN1/FERMT2/MPRIP/SVIL/MYO10/TLN1/PHACTR2/DAAM1/CNN3/PARVA/S100A4/MSN/MYO9A/MACF1	57
GO:0005518	collagen binding	24/510	69/18367	1.86954403116982e-20	4.06937417451297e-18	DCN/COL6A1/LUM/SPARC/COL6A2/ITGA1/THBS1/NID1/AEBP1/NID2/PCOLCE/ANTXR1/DDR2/COL5A3/SPARCL1/CTSK/ITGB1/SERPINH1/COL14A1/P3H4/TGFBI/CRTAP/PDGFA/ADAM9	24
GO:0019838	growth factor binding	30/510	141/18367	2.0338865434521e-18	3.32031978218556e-16	COL1A2/COL3A1/COL1A1/COL6A1/IGFBP7/IGFBP5/THBS1/COL5A1/IGFBP2/PXDN/PDGFRB/IGFBP4/LTBP2/PDGFRA/LRRC32/LTBP4/COL4A1/A2M/OSMR/TWSG1/IGFBP3/FGFR1/IL1R1/IL6ST/LTBP1/HTRA1/PDGFA/BMPR2/CRIM1/LIFR	30
GO:0030020	extracellular matrix structural constituent conferring tensile strength	17/510	41/18367	2.18293994312278e-16	2.85091956571835e-14	COL1A2/COL3A1/COL1A1/COL6A1/COL6A2/COL6A3/COL5A1/COL18A1/COL5A3/COL12A1/COL5A2/COL27A1/COL15A1/COL4A1/COL8A1/COL4A2/COL14A1	17
GO:0005178	integrin binding	27/510	144/18367	3.01749379923988e-15	3.2840390848394e-13	COL3A1/EGFL6/THBS1/COL5A1/THY1/MFGE8/ADAMTS5/EDIL3/EMILIN1/LTBP4/FBLN5/CD81/ITGB1/MYH9/TIMP2/DST/ACTN4/IGF2/FBN1/LAMB2/ACTN1/LAMB1/FERMT2/TGFBI/TLN1/ISG15/ADAM9	27
GO:0048407	platelet-derived growth factor binding	9/510	11/18367	4.79265107691394e-13	4.47085879032115e-11	COL1A2/COL3A1/COL1A1/COL6A1/COL5A1/PDGFRB/PDGFRA/COL4A1/PDGFA	9
GO:0051015	actin filament binding	29/510	217/18367	2.39259149214024e-12	1.95295280545947e-10	TAGLN/TPM2/MYH11/PLS3/ANTXR1/MYO1B/FLNA/NEXN/TPM1/LASP1/MARCKS/HIP1/TPM4/MARCKSL1/MYH9/SYNE1/SPTBN1/LIMA1/ACTN4/GSN/DSTN/CFL2/ACTN1/FERMT2/MPRIP/SVIL/MYO10/TLN1/MACF1	29
GO:0050840	extracellular matrix binding	15/510	56/18367	2.09211364007699e-11	1.51794467441141e-09	DCN/SPARC/THBS1/NID1/CD248/ELN/ADAMTS5/OLFML2B/SPARCL1/FBLN2/LGALS1/BGN/ITGB1/TGFBI/ADAM9	15
GO:0097493	structural molecule activity conferring elasticity	8/510	11/18367	5.13322884995483e-11	3.35199843902051e-09	ELN/EMILIN1/FBLN2/FBLN5/EMILIN2/LAMC1/FBN1/AHNAK	8
GO:0005539	glycosaminoglycan binding	25/510	230/18367	6.39474444423191e-09	3.79615283825767e-07	DCN/THBS1/COL5A1/LTBP2/SLIT3/PCOLCE/PRELP/SEMA5A/ADAMTS5/CFH/COL5A3/EFEMP2/CRISPLD2/LTBP4/VCAN/BGN/SULF2/LIPG/FGFR1/MDK/FSTL1/FBN1/CCDC80/ADAMTS1/SOD3	25
GO:0008201	heparin binding	19/510	166/18367	1.88125247799349e-07	1.02371489010813e-05	THBS1/COL5A1/LTBP2/SLIT3/PCOLCE/PRELP/ADAMTS5/CFH/COL5A3/EFEMP2/CRISPLD2/LIPG/FGFR1/MDK/FSTL1/FBN1/CCDC80/ADAMTS1/SOD3	19
GO:0046332	SMAD binding	13/510	79/18367	2.48041089470332e-07	1.24592947249328e-05	COL1A2/TGFB1I1/MYOCD/COL5A2/FLNA/CITED2/HIPK2/SMAD5/FERMT2/JUN/MEF2A/ZMIZ1/TCF12	13
GO:0030021	extracellular matrix structural constituent conferring compression resistance	7/510	22/18367	1.45018406093523e-06	6.52948327181148e-05	DCN/LUM/OGN/PRELP/VCAN/BGN/HSPG2	7
GO:1901681	sulfur compound binding	23/510	265/18367	1.49988130286634e-06	6.52948327181148e-05	THBS1/COL5A1/LTBP2/SLIT3/PCOLCE/PRELP/SEMA5A/ADAMTS5/CFH/COL5A3/EFEMP2/ENPP1/CRISPLD2/LIPG/FGFR1/MGST1/MDK/FSTL1/FBN1/CCDC80/ADAMTS1/GSTM3/SOD3	23
GO:0051371	muscle alpha-actinin binding	6/510	15/18367	1.79987313811537e-06	6.92384121199088e-05	SYNPO2/PDLIM3/PDLIM7/PDLIM5/PALLD/PKD2	6
GO:0008307	structural constituent of muscle	9/510	42/18367	1.80253140281539e-06	6.92384121199088e-05	TPM2/MYL9/MYH11/NEXN/TPM1/SORBS2/TPM4/MYL6/CSRP1	9
GO:0005516	calmodulin binding	19/510	201/18367	3.52563268522502e-06	0.000127902119080663	MYLK/MYH11/AEBP1/AKAP12/CNN1/MYO1B/ADCY3/CALD1/MARCKS/SLC8A1/TJP1/ATP2B4/MARCKSL1/MYH9/SPTBN1/SNTB2/CNN2/MYO10/CNN3	19
GO:0019955	cytokine binding	15/510	139/18367	7.58667083687745e-06	0.000260741897709525	THBS1/PXDN/LRRC32/LTBP4/A2M/OSMR/TWSG1/ITGB1/IL1R1/IL6ST/LTBP1/ZFP36/PLP2/BMPR2/LIFR	15
GO:0005520	insulin-like growth factor binding	7/510	29/18367	1.12109937957266e-05	0.000366038947430474	IGFBP7/IGFBP5/IGFBP2/IGFBP4/IGFBP3/HTRA1/CRIM1	7
GO:0005161	platelet-derived growth factor receptor binding	5/510	15/18367	3.85929296702967e-05	0.00120005633689066	PDGFRB/PDGFRA/IL1R1/PDGFA/PTEN	5
GO:0140297	DNA-binding transcription factor binding	26/510	394/18367	4.47591425087771e-05	0.00132853272991961	TGFB1I1/HAND2/RUNX1T1/MYOCD/IFI27/MTDH/MEF2C/RERG/ACTB/ACTN4/CITED2/HIPK2/NOTCH2/HDAC7/HSPB1/TACC1/NCOR2/JUN/MEF2A/STAT3/CTBP2/NR4A1/RBFOX2/NCOA7/NBN/TCF12	26
GO:0042805	actinin binding	7/510	36/18367	5.06736739177586e-05	0.00137874621117901	SYNPO2/PDLIM3/PDLIM7/PDLIM5/PALLD/CSRP1/PKD2	7
GO:0043394	proteoglycan binding	7/510	36/18367	5.06736739177586e-05	0.00137874621117901	THBS1/NID1/COL5A1/SEMA5A/CFH/COL5A3/CTSK	7
GO:0045296	cadherin binding	23/510	332/18367	5.86369151207572e-05	0.00153159622295418	CDH11/MYO1B/FLNA/LASP1/CALD1/NOTCH3/PDLIM5/VCL/ITGB1/TJP1/MYH9/SPTBN1/LIMA1/CNN2/MPRIP/AHNAK/TLN1/CNN3/PARVA/GOLGA3/EPN2/MACF1/BMPR2	23
GO:0051393	alpha-actinin binding	6/510	27/18367	8.0153015485313e-05	0.00201307381199651	SYNPO2/PDLIM3/PDLIM7/PDLIM5/PALLD/PKD2	6
GO:0001968	fibronectin binding	6/510	28/18367	9.9636884369524e-05	0.00240973649975182	IGFBP5/THBS1/CTSK/IGFBP3/ITGB1/CCDC80	6
GO:0046982	protein heterodimerization activity	22/510	328/18367	0.000134941819052932	0.00304814386493969	TPM2/AOC3/AGTR1/TPM1/TCF4/HIP1/MEF2C/ITGB1/EXT1/TPM4/CAV1/ZHX1/CAV2/PDGFA/MEF2A/XBP1/ATF3/PIK3R1/NR4A1/TCF12/AHR/SOS1	22
GO:0005200	structural constituent of cytoskeleton	11/510	103/18367	0.000135369329377107	0.00304814386493969	TPM1/VIM/SORBS2/TUBA1A/HIP1/SORBS3/ACTB/SPTBN1/TLN1/MSN/ACTG1	11
GO:0098631	cell adhesion mediator activity	8/510	59/18367	0.000213676392822269	0.00465102281709805	ITGA1/EMILIN1/NEXN/PDLIM5/ITGB1/PALLD/CNN3/NPTN	8
GO:0031994	insulin-like growth factor I binding	4/510	13/18367	0.000344069480247996	0.00724765711619166	IGFBP5/IGFBP2/IGFBP4/IGFBP3	4
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	26/510	450/18367	0.000373992896912111	0.00763179255261277	HAND2/MEIS1/PLAGL1/TCF4/FOXO1/NFIA/MAF/MEF2C/NFIB/ETS1/KLF6/NFIC/SOX4/EGR1/NR3C1/MLXIP/CLOCK/JUN/MEF2A/ATF3/STAT3/NR4A1/FOSL2/PBX1/TCF12/VEZF1	26
GO:0050431	transforming growth factor beta binding	5/510	24/18367	0.000444209551701403	0.008774989800782	THBS1/LRRC32/LTBP4/TWSG1/LTBP1	5
GO:0001216	DNA-binding transcription activator activity	26/510	456/18367	0.000456890740010089	0.008774989800782	HAND2/MEIS1/PLAGL1/TCF4/FOXO1/NFIA/MAF/MEF2C/NFIB/ETS1/KLF6/NFIC/SOX4/EGR1/NR3C1/MLXIP/CLOCK/JUN/MEF2A/ATF3/STAT3/NR4A1/FOSL2/PBX1/TCF12/VEZF1	26
GO:0035259	glucocorticoid receptor binding	4/510	14/18367	0.000471165841350033	0.00879060841147348	TACC1/NCOR2/STAT3/NR4A1	4
GO:0035035	histone acetyltransferase binding	5/510	25/18367	0.000542694176485788	0.00984386936792277	MYOCD/ETS1/EGR1/CITED2/MEF2A	5
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	19/510	299/18367	0.000734213513270743	0.0129578763288053	TGFB1I1/MYOCD/IFI27/MTDH/RERG/ACTB/ACTN4/CITED2/HIPK2/NOTCH2/HSPB1/TACC1/NCOR2/JUN/MEF2A/STAT3/CTBP2/NR4A1/NCOA7	19
GO:0043236	laminin binding	5/510	28/18367	0.000937334210533726	0.0161073484073295	THBS1/NID1/LGALS1/ITGB1/ADAM9	5
GO:0003713	transcription coactivator activity	17/510	262/18367	0.00109268224198994	0.0182954231799855	TGFB1I1/MYOCD/MTDH/ETS1/ACTN4/ACTN1/CITED2/HIPK2/TACC1/ARID5B/RBPMS/DDX17/WWTR1/CTBP2/NCOA7/MAML2/ZMIZ1	17
GO:0044325	transmembrane transporter binding	11/510	133/18367	0.00121773374214737	0.0198795033405558	FXYD1/FHL1/FLNA/SLC8A1/CAV1/ACTN4/TSPO/ACTN1/PKD2/CALM2/NPTN	11
GO:0098918	structural constituent of synapse	4/510	18/18367	0.0013187175129936	0.0210029886825567	ACTB/ACTN1/CTBP2/ACTG1	4
GO:0002020	protease binding	11/510	135/18367	0.00137474012466419	0.0213739357477551	COL1A2/COL3A1/COL1A1/TIMP1/A2M/ITGB1/IL1R1/TIMP2/TIMP3/SH3PXD2A/PTEN	11
GO:0071889	14-3-3 protein binding	5/510	32/18367	0.00175316247065469	0.0266236068218027	SYNPO2/ZFP36L1/HDAC7/ZFP36/PPP1R12A	5
GO:0070888	E-box binding	6/510	48/18367	0.00203106312783403	0.0301428232380823	HAND2/ZEB1/TCF4/CLOCK/TCF12/AHR	6
GO:0019199	transmembrane receptor protein kinase activity	11/510	143/18367	0.00217772236859006	0.0313401451470547	PDGFRB/DDR2/PDGFRA/LTBP4/AXL/FGFR1/DYRK2/LTBP1/JAK1/BMPR2/CRIM1	11
GO:0005522	profilin binding	3/510	10/18367	0.0022077284483377	0.0313401451470547	RHOQ/ENAH/ACTG1	3
GO:0019208	phosphatase regulator activity	9/510	107/18367	0.00295441080357695	0.0400938580258824	PPP1R14A/ZEB2/IGFBP3/PPP1R12B/CALM2/PHACTR2/SBF2/BMPR2/PPP1R12A	9
GO:0099186	structural constituent of postsynapse	3/510	11/18367	0.00297338033350045	0.0400938580258824	ACTB/ACTN1/ACTG1	3
GO:0004879	nuclear receptor activity	6/510	52/18367	0.00306997381515179	0.0400938580258824	NR2F1/NR2F2/NR3C1/STAT3/NR4A1/AHR	6
GO:0098531	ligand-activated transcription factor activity	6/510	52/18367	0.00306997381515179	0.0400938580258824	NR2F1/NR2F2/NR3C1/STAT3/NR4A1/AHR	6
GO:0005024	transforming growth factor beta-activated receptor activity	3/510	12/18367	0.00388333000470072	0.048765663328261	LTBP4/LTBP1/BMPR2	3
GO:0017166	vinculin binding	3/510	12/18367	0.00388333000470072	0.048765663328261	SORBS3/ACTN1/TLN1	3
GO:0005080	protein kinase C binding	6/510	55/18367	0.00407724455020825	0.0502347300242638	FLNA/MARCKS/PDLIM5/HDAC7/HSPB1/ADAM9	6
GO:0072341	modified amino acid binding	8/510	93/18367	0.00432751885066049	0.0523309223978019	THBS1/MFGE8/GAS6/SYTL2/AXL/MGST1/TLN1/GSTM3	8
GO:0030374	nuclear receptor coactivator activity	6/510	56/18367	0.00446178372219453	0.0529735412835096	ETS1/ACTN4/ACTN1/TACC1/NCOA7/ZMIZ1	6
GO:0004713	protein tyrosine kinase activity	10/510	136/18367	0.0046944198016378	0.0547402880440979	PDGFRB/DDR2/PDGFRA/AXL/PEAK1/FGFR1/DYRK2/HIPK2/JAK1/CRIM1	10
GO:0061134	peptidase regulator activity	14/510	230/18367	0.00513371909414045	0.0588126064644511	COL6A3/WFDC1/PCOLCE/GAS6/TFPI/TIMP1/A2M/GPC3/SERPING1/CAV1/TIMP2/SERPINH1/TIMP3/CRIM1	14
GO:0003712	transcription coregulator activity	24/510	489/18367	0.00527017656521341	0.0593349189152475	TGFB1I1/RUNX1T1/MYOCD/MTDH/LMCD1/ETS1/ACTN4/ACTN1/CITED2/HIPK2/HDAC7/TACC1/ARID5B/NCOR2/RBPMS/DDX17/ZMYND11/WWTR1/MED13L/CTBP2/RBFOX2/NCOA7/MAML2/ZMIZ1	24
GO:0042974	retinoic acid receptor binding	4/510	26/18367	0.00540636281506414	0.0598365240379133	ACTN4/TACC1/NCOR2/CTBP2	4
GO:0005543	phospholipid binding	23/510	466/18367	0.00583674196433089	0.0635232083784679	PLA2G2A/THBS1/THY1/MAP1B/MFGE8/MYO1B/GAS6/SYTL2/AXL/HIP1/LPAR1/JAG1/SPTBN1/GSN/SH3PXD2A/FERMT2/SVIL/MYO10/TLN1/AIDA/MAP1LC3A/SBF2/EPN2	23
GO:0030414	peptidase inhibitor activity	12/510	187/18367	0.00614331199605284	0.065763651367582	COL6A3/WFDC1/GAS6/TFPI/TIMP1/A2M/GPC3/SERPING1/TIMP2/SERPINH1/TIMP3/CRIM1	12
GO:0001786	phosphatidylserine binding	6/510	60/18367	0.00627086731723396	0.066046392873448	THBS1/MFGE8/GAS6/SYTL2/AXL/TLN1	6
GO:0050998	nitric-oxide synthase binding	3/510	15/18367	0.00754947654138041	0.0782509235162128	ACTB/ATP2B4/CAV1	3
GO:0030674	protein-macromolecule adaptor activity	16/510	296/18367	0.00885246898712528	0.0903228476342626	COL1A2/SYNPO2/GAS6/PAG1/SORBS2/HIP1/MYH9/EPS8/SYNE1/CAV1/COL14A1/CAV2/STON1/STAT3/PIK3R1/AKAP13	16
GO:0008191	metalloendopeptidase inhibitor activity	3/510	16/18367	0.0091025093212075	0.0914452090268999	TIMP1/TIMP2/TIMP3	3
GO:0000146	microfilament motor activity	4/510	31/18367	0.0102047631046109	0.100965307686529	MYO1B/MYL6/MYH9/MYO10	4
GO:0098632	cell-cell adhesion mediator activity	5/510	49/18367	0.0113005910204644	0.110138596065123	NEXN/PDLIM5/PALLD/CNN3/NPTN	5
GO:0019887	protein kinase regulator activity	12/510	204/18367	0.0118465616141477	0.113600825745145	CAMK2N1/GAS6/CCND2/PKIG/IGF2/CALM2/HSPB1/PRKAR1A/PARVA/BMPR2/TAOK1/CCNG2	12
GO:0004866	endopeptidase inhibitor activity	11/510	180/18367	0.012003762597879	0.113600825745145	COL6A3/WFDC1/GAS6/TFPI/TIMP1/A2M/SERPING1/TIMP2/SERPINH1/TIMP3/CRIM1	11
GO:0004222	metalloendopeptidase activity	8/510	111/18367	0.0122172877316044	0.113969841267681	ADAMTS5/ADAMTS2/ADAMTS9/MMP2/ADAM12/BMP1/ADAMTS1/ADAM9	8
GO:0019956	chemokine binding	4/510	33/18367	0.0127076392795688	0.116874485205048	A2M/ITGB1/ZFP36/PLP2	4
GO:0019207	kinase regulator activity	13/510	233/18367	0.0135982386242472	0.123328469744908	CAMK2N1/GAS6/CCND2/PKIG/IGF2/CALM2/HSPB1/PRKAR1A/PARVA/PIK3R1/BMPR2/TAOK1/CCNG2	13
GO:0043548	phosphatidylinositol 3-kinase binding	4/510	34/18367	0.0140933643098065	0.126068039647995	PDGFRB/AXL/GSN/PIK3R1	4
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	3/510	19/18367	0.0148108473135515	0.130695720212826	LTBP4/LTBP1/BMPR2	3
GO:0008083	growth factor activity	10/510	162/18367	0.0151856225329986	0.131749184317357	OGN/HGF/TIMP1/TGFB2/JAG1/MDK/CLEC11A/IGF2/BMP1/PDGFA	10
GO:0060090	molecular adaptor activity	18/510	369/18367	0.0153337488638884	0.131749184317357	COL1A2/SYNPO2/GAS6/PAG1/SORBS2/HIP1/MYH9/EPS8/SYNE1/CAV1/COL14A1/CAV2/ITSN1/STON1/STAT3/PIK3R1/DLGAP4/AKAP13	18
GO:0019211	phosphatase activator activity	3/510	20/18367	0.0170719137127441	0.144778696810674	IGFBP3/CALM2/BMPR2	3
GO:0016922	nuclear receptor binding	9/510	144/18367	0.0192288178462803	0.159947397363487	TGFB1I1/RERG/ACTN4/TACC1/NCOR2/STAT3/CTBP2/NR4A1/NCOA7	9
GO:0004867	serine-type endopeptidase inhibitor activity	7/510	98/18367	0.0193504508295796	0.159947397363487	COL6A3/WFDC1/TFPI/A2M/SERPING1/SERPINH1/CRIM1	7
GO:0061135	endopeptidase regulator activity	11/510	194/18367	0.0199126979139598	0.162537396722697	COL6A3/WFDC1/GAS6/TFPI/TIMP1/A2M/SERPING1/TIMP2/SERPINH1/TIMP3/CRIM1	11
GO:0004714	transmembrane receptor protein tyrosine kinase activity	8/510	124/18367	0.0223948105050123	0.180540879750285	PDGFRB/DDR2/PDGFRA/AXL/FGFR1/DYRK2/JAK1/CRIM1	8
GO:0005158	insulin receptor binding	3/510	23/18367	0.0249483102451921	0.196280079398921	ENPP1/IGF2/PIK3R1	3
GO:0005212	structural constituent of eye lens	3/510	23/18367	0.0249483102451921	0.196280079398921	CRYAB/HSPB6/VIM	3
GO:0004690	cyclic nucleotide-dependent protein kinase activity	2/510	10/18367	0.0298751923379689	0.229511771725808	PRKG1/AKAP13	2
GO:0008190	eukaryotic initiation factor 4E binding	2/510	10/18367	0.0298751923379689	0.229511771725808	EIF4EBP1/EIF4EBP2	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/510	25/18367	0.0311111305188081	0.236227537543973	RBMS3/ZFP36L1/ZFP36	3
GO:0048156	tau protein binding	4/510	45/18367	0.035734401003247	0.260136138084048	HSPA2/ACTB/ROCK2/TAOK1	4
GO:0008603	cAMP-dependent protein kinase regulator activity	2/510	11/18367	0.0358533727834063	0.260136138084048	PKIG/PRKAR1A	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/510	11/18367	0.0358533727834063	0.260136138084048	QSOX1/PCYOX1	2
GO:0043295	glutathione binding	2/510	11/18367	0.0358533727834063	0.260136138084048	MGST1/GSTM3	2
GO:0003714	transcription corepressor activity	10/510	187/18367	0.0363317414068027	0.260710188336727	RUNX1T1/LMCD1/CITED2/HIPK2/HDAC7/NCOR2/ZMYND11/WWTR1/CTBP2/RBFOX2	10
GO:0008429	phosphatidylethanolamine binding	2/510	12/18367	0.0422473813391474	0.296640215209283	MFGE8/MAP1LC3A	2
GO:1900750	oligopeptide binding	2/510	12/18367	0.0422473813391474	0.296640215209283	MGST1/GSTM3	2
GO:0070851	growth factor receptor binding	8/510	141/18367	0.0431873519092711	0.300014263795256	PDGFRB/PDGFRA/HIP1/IL1R1/IL6ST/PDGFA/NPTN/PTEN	8
GO:0004860	protein kinase inhibitor activity	5/510	70/18367	0.0449269049612663	0.308813357260072	CAMK2N1/PKIG/HSPB1/PRKAR1A/PARVA	5
GO:0070717	poly-purine tract binding	3/510	29/18367	0.0455883701031369	0.310095892472379	ATXN1/RBMS3/RBPMS	3
GO:0043539	protein serine/threonine kinase activator activity	4/510	49/18367	0.0466583488526267	0.313885658581464	IGF2/CALM2/BMPR2/TAOK1	4
GO:0019902	phosphatase binding	10/510	196/18367	0.0474228291823095	0.313885658581464	ITGA1/SYTL2/FOXO1/ATP2B4/JAK1/EIF4EBP1/HSP90B1/SBF2/STAT3/PIK3R1	10
GO:0008179	adenylate cyclase binding	2/510	13/18367	0.0490296128258949	0.313885658581464	AKAP12/CALM2	2
GO:0032036	myosin heavy chain binding	2/510	13/18367	0.0490296128258949	0.313885658581464	MYL9/AXL	2
GO:0034236	protein kinase A catalytic subunit binding	2/510	13/18367	0.0490296128258949	0.313885658581464	PRKAR1A/PJA2	2
GO:0072542	protein phosphatase activator activity	2/510	13/18367	0.0490296128258949	0.313885658581464	IGFBP3/CALM2	2
GO:0015485	cholesterol binding	4/510	50/18367	0.0496480068393372	0.31475872297172	APOD/CD81/CAV1/TSPO	4
GO:0051018	protein kinase A binding	4/510	51/18367	0.0527406343369473	0.331150329057948	AKAP12/PRKAR1A/PJA2/AKAP13	4
GO:0004252	serine-type endopeptidase activity	9/510	174/18367	0.0541673968445461	0.333387843878508	PRSS23/C1R/C1S/CTSK/MMP2/BMP1/PREPL/CFD/HTRA1	9
GO:0003725	double-stranded RNA binding	5/510	74/18367	0.0547523762240357	0.333387843878508	VIM/MTDH/ACTN1/MBNL1/MSN	5
GO:0019210	kinase inhibitor activity	5/510	74/18367	0.0547523762240357	0.333387843878508	CAMK2N1/PKIG/HSPB1/PRKAR1A/PARVA	5
GO:0001217	DNA-binding transcription repressor activity	14/510	313/18367	0.0551391839799064	0.333387843878508	NR2F1/AEBP1/TBX2/ZEB1/PLAGL1/ZEB2/SOX6/NR3C1/SMAD5/IFI16/ZFHX3/JUN/ATF3/ZBTB4	14
GO:0070411	I-SMAD binding	2/510	14/18367	0.0561736692552947	0.333467327488249	TGFB1I1/SMAD5	2
GO:0071837	HMG box domain binding	2/510	14/18367	0.0561736692552947	0.333467327488249	JUN/TCF12	2
GO:0019003	GDP binding	5/510	75/18367	0.0573878959791633	0.336132107552142	RAP2A/RRAS/RERG/RHOB/ARL3	5
GO:0019903	protein phosphatase binding	8/510	150/18367	0.0581404240552826	0.336132107552142	ITGA1/FOXO1/ATP2B4/JAK1/EIF4EBP1/HSP90B1/STAT3/PIK3R1	8
GO:0005096	GTPase activator activity	19/510	462/18367	0.0581668118734947	0.336132107552142	THY1/CHN1/DLC1/ARHGAP42/FARP1/ARHGEF6/RIN2/ARHGEF12/PSD3/SEC23A/STARD13/ITSN1/JUN/SBF2/ARHGAP5/MYO9A/CHM/AKAP13/SOS1	19
GO:0044389	ubiquitin-like protein ligase binding	14/510	316/18367	0.0587327951145155	0.336425572015602	TXNIP/FOXO1/CKB/VCL/SMAD5/JAK1/PRKAR1A/MAP1LC3A/ISG15/JUN/CCDC50/SMC6/ACTG1/STAT2	14
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/510	15/18367	0.0636543142882045	0.361445802001718	PDE3A/PDE8B	2
GO:0030291	protein serine/threonine kinase inhibitor activity	3/510	34/18367	0.0675331355051765	0.380164978317933	PKIG/HSPB1/PRKAR1A	3
GO:0005159	insulin-like growth factor receptor binding	2/510	16/18367	0.0714474292834898	0.384974217657212	IGF2/PIK3R1	2
GO:0005521	lamin binding	2/510	16/18367	0.0714474292834898	0.384974217657212	IFI27/SYNE1	2
GO:0005523	tropomyosin binding	2/510	16/18367	0.0714474292834898	0.384974217657212	LMOD1/CALD1	2
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/510	16/18367	0.0714474292834898	0.384974217657212	AOC3/MAOA	2
GO:0035497	cAMP response element binding	2/510	16/18367	0.0714474292834898	0.384974217657212	JUN/TCF12	2
GO:0031625	ubiquitin protein ligase binding	13/510	297/18367	0.0719247389803673	0.384974217657212	TXNIP/FOXO1/CKB/VCL/SMAD5/JAK1/PRKAR1A/MAP1LC3A/ISG15/JUN/CCDC50/SMC6/ACTG1	13
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	4/510	57/18367	0.0734254926697877	0.389811761897328	MSRB3/NXN/QSOX1/PCYOX1	4
GO:0035591	signaling adaptor activity	5/510	81/18367	0.0746990341860819	0.393374752608963	PAG1/EPS8/STAT3/PIK3R1/AKAP13	5
GO:0035091	phosphatidylinositol binding	12/510	271/18367	0.0762988157213849	0.393432355966	THY1/MYO1B/SYTL2/HIP1/GSN/SH3PXD2A/FERMT2/SVIL/MYO10/TLN1/AIDA/SBF2	12
GO:0000217	DNA secondary structure binding	3/510	36/18367	0.0774283360537587	0.393432355966	HAND2/MEF2C/KMT2A	3
GO:1902936	phosphatidylinositol bisphosphate binding	6/510	107/18367	0.0776144003261764	0.393432355966	MYO1B/SYTL2/HIP1/GSN/SH3PXD2A/SVIL	6
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	5/510	82/18367	0.0778315550925665	0.393432355966	MYO1B/SYTL2/GSN/SH3PXD2A/SVIL	5
GO:0043395	heparan sulfate proteoglycan binding	2/510	17/18367	0.0795299708843981	0.393432355966	SEMA5A/CFH	2
GO:0046965	retinoid X receptor binding	2/510	17/18367	0.0795299708843981	0.393432355966	TACC1/NCOR2	2
GO:0052745	inositol phosphate phosphatase activity	2/510	17/18367	0.0795299708843981	0.393432355966	INPP4B/PTEN	2
GO:0070064	proline-rich region binding	2/510	17/18367	0.0795299708843981	0.393432355966	ITSN1/RABAC1	2
GO:0008237	metallopeptidase activity	9/510	190/18367	0.0835928371688017	0.410421974971636	CPXM1/ADAMTS5/ADAMTS2/ADAMTS9/MMP2/ADAM12/BMP1/ADAMTS1/ADAM9	9
GO:0032934	sterol binding	4/510	60/18367	0.0850971783442903	0.414526691315663	APOD/CD81/CAV1/TSPO	4
GO:0008236	serine-type peptidase activity	9/510	191/18367	0.0856984737023192	0.414526691315663	PRSS23/C1R/C1S/CTSK/MMP2/BMP1/PREPL/CFD/HTRA1	9
GO:0098641	cadherin binding involved in cell-cell adhesion	2/510	18/18367	0.087879930091271	0.417066887309605	PDLIM5/CNN3	2
GO:0030695	GTPase regulator activity	19/510	488/18367	0.0881397097223973	0.417066887309605	THY1/CHN1/DLC1/ARHGAP42/FARP1/ARHGEF6/RIN2/ARHGEF12/PSD3/SEC23A/STARD13/ITSN1/JUN/SBF2/ARHGAP5/MYO9A/CHM/AKAP13/SOS1	19
GO:0060589	nucleoside-triphosphatase regulator activity	19/510	488/18367	0.0881397097223973	0.417066887309605	THY1/CHN1/DLC1/ARHGAP42/FARP1/ARHGEF6/RIN2/ARHGEF12/PSD3/SEC23A/STARD13/ITSN1/JUN/SBF2/ARHGAP5/MYO9A/CHM/AKAP13/SOS1	19
GO:0016209	antioxidant activity	5/510	86/18367	0.0910535544875806	0.424699793431358	PXDN/NXN/MGST1/GPX8/SOD3	5
GO:0042562	hormone binding	5/510	86/18367	0.0910535544875806	0.424699793431358	RAMP1/EDNRB/NR3C1/TSPO/PIK3R1	5
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	13/510	310/18367	0.0927448935401494	0.429387075252972	NR2F1/AEBP1/TBX2/ZEB1/PLAGL1/ZEB2/NR3C1/SMAD5/IFI16/ZFHX3/JUN/ATF3/ZBTB4	13
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	3/510	39/18367	0.0933736059508759	0.429387075252972	MYO1B/FERMT2/MYO10	3
GO:0017171	serine hydrolase activity	9/510	195/18367	0.0944354353214644	0.431233141712701	PRSS23/C1R/C1S/CTSK/MMP2/BMP1/PREPL/CFD/HTRA1	9
GO:0004129	cytochrome-c oxidase activity	2/510	19/18367	0.0964762927710026	0.434475994341136	COX4I2/COX7A1	2
GO:0035615	clathrin adaptor activity	2/510	19/18367	0.0964762927710026	0.434475994341136	HIP1/STON1	2
GO:0003774	cytoskeletal motor activity	6/510	114/18367	0.0979666372161692	0.43565283302976	MYH11/MYO1B/MYL6/MYH9/MYO10/MYO9A	6
GO:0048306	calcium-dependent protein binding	5/510	88/18367	0.0980719241276794	0.43565283302976	A2M/ATP2B4/SEC31A/CALM2/S100A4	5
GO:0042169	SH2 domain binding	3/510	40/18367	0.0989660711106856	0.436654354292417	DLC1/PAG1/ARHGAP5	3
GO:0043178	alcohol binding	5/510	89/18367	0.101680700358879	0.445620787478844	RBP1/APOD/CD81/CAV1/TSPO	5
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/510	20/18367	0.105299001555254	0.446495116984289	TCF4/AHR	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/510	20/18367	0.105299001555254	0.446495116984289	AOC3/MAOA	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/510	20/18367	0.105299001555254	0.446495116984289	COX4I2/COX7A1	2
GO:0030506	ankyrin binding	2/510	20/18367	0.105299001555254	0.446495116984289	SLC8A1/SPTBN1	2
GO:0140312	cargo adaptor activity	2/510	20/18367	0.105299001555254	0.446495116984289	HIP1/STON1	2
GO:0031267	small GTPase binding	11/510	259/18367	0.108105397917968	0.455437579615696	FLNA/SYTL2/FARP1/EPS8/CAV1/NCKAP1/DAAM1/ROCK2/CHM/RAB11FIP2/AKAP13	11
GO:1901981	phosphatidylinositol phosphate binding	8/510	173/18367	0.109704842696486	0.459213219748754	MYO1B/SYTL2/HIP1/GSN/SH3PXD2A/FERMT2/SVIL/MYO10	8
GO:0051020	GTPase binding	12/510	291/18367	0.112998672782286	0.469988110361992	FLNA/SYTL2/FARP1/EPS8/CAV1/SPTBN1/NCKAP1/DAAM1/ROCK2/CHM/RAB11FIP2/AKAP13	12
GO:0097110	scaffold protein binding	4/510	67/18367	0.115543959675838	0.47753294726786	VIM/IL6ST/ATP2B4/CAV2	4
GO:0004602	glutathione peroxidase activity	2/510	22/18367	0.123547792528328	0.501097568453406	MGST1/GPX8	2
GO:0009975	cyclase activity	2/510	22/18367	0.123547792528328	0.501097568453406	GUCY1A2/ADCY3	2
GO:0050321	tau-protein kinase activity	2/510	22/18367	0.123547792528328	0.501097568453406	ROCK2/TAOK1	2
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/510	23/18367	0.132938219412436	0.519812319019886	PDE3A/PDE8B	2
GO:0008143	poly(A) binding	2/510	23/18367	0.132938219412436	0.519812319019886	RBMS3/RBPMS	2
GO:0016849	phosphorus-oxygen lyase activity	2/510	23/18367	0.132938219412436	0.519812319019886	GUCY1A2/ADCY3	2
GO:0017134	fibroblast growth factor binding	2/510	23/18367	0.132938219412436	0.519812319019886	THBS1/FGFR1	2
GO:0050750	low-density lipoprotein particle receptor binding	2/510	23/18367	0.132938219412436	0.519812319019886	HSPG2/HSP90B1	2
GO:0070412	R-SMAD binding	2/510	23/18367	0.132938219412436	0.519812319019886	MYOCD/JUN	2
GO:0008017	microtubule binding	11/510	271/18367	0.135269670601999	0.525780326804199	CRYAB/MAP1B/DST/MAP9/MAP4K4/MAP4/DPYSL2/MAP1LC3A/CNN3/ARL3/MACF1	11
GO:0043495	protein-membrane adaptor activity	2/510	24/18367	0.142483614587014	0.550543197191244	MYH9/SYNE1	2
GO:0005496	steroid binding	5/510	100/18367	0.145507597002698	0.552032336153488	APOD/CD81/CAV1/NR3C1/TSPO	5
GO:0140678	molecular function inhibitor activity	6/510	128/18367	0.146159438601627	0.552032336153488	ID4/TXNIP/PPP1R12B/CAV1/CALM2/PPP1R12A	6
GO:0015026	coreceptor activity	3/510	48/18367	0.148061944635177	0.552032336153488	RAMP1/ITGB1/PTK7	3
GO:0030295	protein kinase activator activity	5/510	101/18367	0.149842844476466	0.552032336153488	GAS6/IGF2/CALM2/BMPR2/TAOK1	5
GO:0017022	myosin binding	4/510	74/18367	0.15003214476267	0.552032336153488	MYL9/AXL/CALD1/GSN	4
GO:0003887	DNA-directed DNA polymerase activity	2/510	25/18367	0.152168178419032	0.552032336153488	REV3L/POLK	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	2/510	25/18367	0.152168178419032	0.552032336153488	PDE3A/PDE8B	2
GO:0005112	Notch binding	2/510	25/18367	0.152168178419032	0.552032336153488	JAG1/NCOR2	2
GO:0005160	transforming growth factor beta receptor binding	2/510	25/18367	0.152168178419032	0.552032336153488	TGFB2/FERMT2	2
GO:0008266	poly(U) RNA binding	2/510	25/18367	0.152168178419032	0.552032336153488	ATXN1/RBMS3	2
GO:0008327	methyl-CpG binding	2/510	25/18367	0.152168178419032	0.552032336153488	ZBTB38/ZBTB4	2
GO:0004364	glutathione transferase activity	2/510	26/18367	0.161976866095097	0.581158755824715	MGST1/GSTM3	2
GO:0030371	translation repressor activity	2/510	26/18367	0.161976866095097	0.581158755824715	EIF4EBP1/EIF4EBP2	2
GO:1990782	protein tyrosine kinase binding	5/510	105/18367	0.167712163760349	0.596817124881316	GAS6/ITGB1/PIK3R1/PTEN/BMPR2	5
GO:0004601	peroxidase activity	3/510	51/18367	0.168168990778196	0.596817124881316	PXDN/MGST1/GPX8	3
GO:0005085	guanyl-nucleotide exchange factor activity	9/510	223/18367	0.169170046117861	0.597062068021144	FARP1/ARHGEF6/RIN2/ARHGEF12/PSD3/ITSN1/SBF2/AKAP13/SOS1	9
GO:0023026	MHC class II protein complex binding	2/510	27/18367	0.171895358021401	0.597062068021144	CD81/B2M	2
GO:0030507	spectrin binding	2/510	27/18367	0.171895358021401	0.597062068021144	EPB41L2/MYO10	2
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/510	27/18367	0.171895358021401	0.597062068021144	INPP4B/PTEN	2
GO:0017046	peptide hormone binding	3/510	52/18367	0.175040412218118	0.604769254912333	RAMP1/EDNRB/PIK3R1	3
GO:0019209	kinase activator activity	5/510	107/18367	0.176947506053742	0.608140639226809	GAS6/IGF2/CALM2/BMPR2/TAOK1	5
GO:0003785	actin monomer binding	2/510	28/18367	0.18191003128037	0.61230541456743	TMSB4X/LIMA1	2
GO:0008187	poly-pyrimidine tract binding	2/510	28/18367	0.18191003128037	0.61230541456743	ATXN1/RBMS3	2
GO:0051861	glycolipid binding	2/510	28/18367	0.18191003128037	0.61230541456743	THY1/HSPA2	2
GO:0070325	lipoprotein particle receptor binding	2/510	28/18367	0.18191003128037	0.61230541456743	HSPG2/HSP90B1	2
GO:0004674	protein serine/threonine kinase activity	14/510	386/18367	0.188303536238308	0.630056179229791	MYLK/PRKG1/LTBP4/DYRK2/CDC42BPA/LTBP1/HIPK2/MAP4K4/ROCK2/BMPR2/MAP4K5/TAOK1/AKT3/AKAP13	14
GO:0099106	ion channel regulator activity	6/510	139/18367	0.190221151776486	0.630056179229791	FXYD1/PRKG1/FLNA/ATP2B4/CAV1/CALM2	6
GO:0047485	protein N-terminus binding	5/510	110/18367	0.19114917571727	0.630056179229791	DCN/PDLIM5/CALM2/NCOR2/NBN	5
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/510	29/18367	0.192007932108313	0.630056179229791	HIP1/SH3PXD2A	2
GO:0051059	NF-kappaB binding	2/510	29/18367	0.192007932108313	0.630056179229791	MTDH/NOTCH2	2
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/510	55/18367	0.196099128413412	0.640263654269792	PXDN/MGST1/GPX8	3
GO:0051287	NAD binding	3/510	56/18367	0.203252185636446	0.660316802092532	UGDH/CYB5R3/CTBP2	3
GO:0030165	PDZ domain binding	4/510	84/18367	0.204991728969781	0.662671282263698	SDC2/ATP2B4/PTEN/CRIM1	4
GO:0016247	channel regulator activity	6/510	145/18367	0.216171141565226	0.670697315788687	FXYD1/PRKG1/FLNA/ATP2B4/CAV1/CALM2	6
GO:0030546	signaling receptor activator activity	17/510	495/18367	0.217114278005826	0.670697315788687	OGN/SEMA5A/WNT2/HGF/GAS6/TIMP1/TGFB2/METRN/JAG1/MDK/CLEC11A/IGF2/FBN1/BMP1/CMTM3/PDGFA/BMPR2	17
GO:0004175	endopeptidase activity	15/510	430/18367	0.217702710727722	0.670697315788687	PRSS23/C1R/ADAMTS5/ADAMTS2/ADAMTS9/C1S/CTSK/MMP2/ADAM12/BMP1/PREPL/CFD/HTRA1/ADAMTS1/ADAM9	15
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3/510	58/18367	0.217732672327526	0.670697315788687	MGST1/CHM/GSTM3	3
GO:0001223	transcription coactivator binding	2/510	32/18367	0.222680949063927	0.670697315788687	FOXO1/AHR	2
GO:0050699	WW domain binding	2/510	32/18367	0.222680949063927	0.670697315788687	TCEAL3/ENAH	2
GO:0051721	protein phosphatase 2A binding	2/510	32/18367	0.222680949063927	0.670697315788687	FOXO1/EIF4EBP1	2
GO:0140658	ATP-dependent chromatin remodeler activity	2/510	32/18367	0.222680949063927	0.670697315788687	CHD9/ATRX	2
GO:0001530	lipopolysaccharide binding	2/510	33/18367	0.232994696643782	0.670697315788687	SPON2/ZRANB2	2
GO:0008200	ion channel inhibitor activity	2/510	33/18367	0.232994696643782	0.670697315788687	CAV1/CALM2	2
GO:0031369	translation initiation factor binding	2/510	33/18367	0.232994696643782	0.670697315788687	EIF4EBP1/EIF4EBP2	2
GO:0008081	phosphoric diester hydrolase activity	4/510	89/18367	0.234402193411251	0.670697315788687	EDNRA/PDE3A/PDE8B/ENPP1	4
GO:0019888	protein phosphatase regulator activity	4/510	89/18367	0.234402193411251	0.670697315788687	PPP1R14A/IGFBP3/CALM2/PHACTR2	4
GO:0016248	channel inhibitor activity	2/510	34/18367	0.243336044214945	0.670697315788687	CAV1/CALM2	2
GO:0035198	miRNA binding	2/510	34/18367	0.243336044214945	0.670697315788687	SOX4/KCNQ1OT1	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/510	34/18367	0.243336044214945	0.670697315788687	INPP4B/PTEN	2
GO:0001094	TFIID-class transcription factor complex binding	1/510	10/18367	0.245477271781771	0.670697315788687	AHR	1
GO:0004465	lipoprotein lipase activity	1/510	10/18367	0.245477271781771	0.670697315788687	LIPG	1
GO:0005432	calcium:sodium antiporter activity	1/510	10/18367	0.245477271781771	0.670697315788687	SLC8A1	1
GO:0005528	FK506 binding	1/510	10/18367	0.245477271781771	0.670697315788687	FKBP10	1
GO:0008172	S-methyltransferase activity	1/510	10/18367	0.245477271781771	0.670697315788687	KMT2A	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/510	10/18367	0.245477271781771	0.670697315788687	MAN2A1	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/510	10/18367	0.245477271781771	0.670697315788687	SH3PXD2A	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/510	10/18367	0.245477271781771	0.670697315788687	CYB5R3	1
GO:0017002	activin-activated receptor activity	1/510	10/18367	0.245477271781771	0.670697315788687	BMPR2	1
GO:0030957	Tat protein binding	1/510	10/18367	0.245477271781771	0.670697315788687	ACTB	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/510	10/18367	0.245477271781771	0.670697315788687	HDAC7	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/510	10/18367	0.245477271781771	0.670697315788687	HDAC7	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/510	10/18367	0.245477271781771	0.670697315788687	INPP4B	1
GO:0034713	type I transforming growth factor beta receptor binding	1/510	10/18367	0.245477271781771	0.670697315788687	FERMT2	1
GO:0035374	chondroitin sulfate binding	1/510	10/18367	0.245477271781771	0.670697315788687	MDK	1
GO:0035612	AP-2 adaptor complex binding	1/510	10/18367	0.245477271781771	0.670697315788687	HIP1	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/510	10/18367	0.245477271781771	0.670697315788687	PIK3R1	1
GO:0045294	alpha-catenin binding	1/510	10/18367	0.245477271781771	0.670697315788687	VCL	1
GO:0046030	inositol trisphosphate phosphatase activity	1/510	10/18367	0.245477271781771	0.670697315788687	INPP4B	1
GO:0050786	RAGE receptor binding	1/510	10/18367	0.245477271781771	0.670697315788687	S100A4	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	1/510	10/18367	0.245477271781771	0.670697315788687	LIPG	1
GO:0051082	unfolded protein binding	5/510	122/18367	0.251491359533095	0.674360849139881	CRYAB/HSPB6/HSPA2/SERPINH1/HSP90B1	5
GO:0023023	MHC protein complex binding	2/510	36/18367	0.264064186279539	0.674360849139881	CD81/B2M	2
GO:0034061	DNA polymerase activity	2/510	36/18367	0.264064186279539	0.674360849139881	REV3L/POLK	2
GO:0097718	disordered domain specific binding	2/510	36/18367	0.264064186279539	0.674360849139881	HSPA2/CALM2	2
GO:0002162	dystroglycan binding	1/510	11/18367	0.266439661681607	0.674360849139881	VCL	1
GO:0004016	adenylate cyclase activity	1/510	11/18367	0.266439661681607	0.674360849139881	ADCY3	1
GO:0005078	MAP-kinase scaffold activity	1/510	11/18367	0.266439661681607	0.674360849139881	AKAP13	1
GO:0005347	ATP transmembrane transporter activity	1/510	11/18367	0.266439661681607	0.674360849139881	SLC25A24	1
GO:0008503	benzodiazepine receptor activity	1/510	11/18367	0.266439661681607	0.674360849139881	TSPO	1
GO:0015368	calcium:cation antiporter activity	1/510	11/18367	0.266439661681607	0.674360849139881	SLC8A1	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/510	11/18367	0.266439661681607	0.674360849139881	DDAH2	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/510	11/18367	0.266439661681607	0.674360849139881	DSEL	1
GO:0019855	calcium channel inhibitor activity	1/510	11/18367	0.266439661681607	0.674360849139881	CALM2	1
GO:0022889	serine transmembrane transporter activity	1/510	11/18367	0.266439661681607	0.674360849139881	SLC38A2	1
GO:0043560	insulin receptor substrate binding	1/510	11/18367	0.266439661681607	0.674360849139881	PIK3R1	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/510	11/18367	0.266439661681607	0.674360849139881	NXN	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/510	11/18367	0.266439661681607	0.674360849139881	ENPP1	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	1/510	11/18367	0.266439661681607	0.674360849139881	LIPG	1
GO:1990459	transferrin receptor binding	1/510	11/18367	0.266439661681607	0.674360849139881	CD81	1
GO:0008022	protein C-terminus binding	7/510	189/18367	0.27264153042074	0.678807201989599	TCF4/FBLN5/HSPG2/ATXN1/DST/KPNA3/RABAC1	7
GO:0005109	frizzled binding	2/510	37/18367	0.274433539548628	0.678807201989599	CTHRC1/WNT2	2
GO:0015035	protein-disulfide reductase activity	2/510	37/18367	0.274433539548628	0.678807201989599	NXN/QSOX1	2
GO:0030551	cyclic nucleotide binding	2/510	37/18367	0.274433539548628	0.678807201989599	PRKG1/PRKAR1A	2
GO:0043531	ADP binding	2/510	37/18367	0.274433539548628	0.678807201989599	MYH9/CYB5R3	2
GO:0071949	FAD binding	2/510	37/18367	0.274433539548628	0.678807201989599	QSOX1/CYB5R3	2
GO:0048018	receptor ligand activity	16/510	487/18367	0.280404676173834	0.683554628043335	OGN/SEMA5A/WNT2/HGF/GAS6/TIMP1/TGFB2/METRN/JAG1/MDK/CLEC11A/IGF2/FBN1/BMP1/CMTM3/PDGFA	16
GO:0004896	cytokine receptor activity	4/510	97/18367	0.283285009303391	0.683554628043335	OSMR/IL1R1/IL6ST/LIFR	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/510	38/18367	0.284795570094458	0.683554628043335	FKBP10/FKBP14	2
GO:0005501	retinoid binding	2/510	38/18367	0.284795570094458	0.683554628043335	RBP1/NR2F2	2
GO:0019840	isoprenoid binding	2/510	38/18367	0.284795570094458	0.683554628043335	RBP1/NR2F2	2
GO:0005165	neurotrophin receptor binding	1/510	12/18367	0.286820778076376	0.683554628043335	PIK3R1	1
GO:0005527	macrolide binding	1/510	12/18367	0.286820778076376	0.683554628043335	FKBP10	1
GO:0017154	semaphorin receptor activity	1/510	12/18367	0.286820778076376	0.683554628043335	PLXND1	1
GO:0042975	peroxisome proliferator activated receptor binding	1/510	12/18367	0.286820778076376	0.683554628043335	TACC1	1
GO:0046790	virion binding	1/510	12/18367	0.286820778076376	0.683554628043335	HIPK2	1
GO:0003684	damaged DNA binding	3/510	68/18367	0.292568748571001	0.685732091299956	SMC6/POLK/NBN	3
GO:0017124	SH3 domain binding	5/510	130/18367	0.294061807515715	0.685732091299956	ENAH/ADAM12/SH3BGRL/ADAM9/SOS1	5
GO:0004402	histone acetyltransferase activity	2/510	39/18367	0.295142703291409	0.685732091299956	CLOCK/EPC1	2
GO:0003925	G protein activity	2/510	40/18367	0.305467789195658	0.685732091299956	RAP2A/RERG	2
GO:0017080	sodium channel regulator activity	2/510	40/18367	0.305467789195658	0.685732091299956	FXYD1/ATP2B4	2
GO:0044183	protein folding chaperone	2/510	40/18367	0.305467789195658	0.685732091299956	HSPA2/HSPB1	2
GO:0004312	fatty acid synthase activity	1/510	13/18367	0.306636708513916	0.685732091299956	ELOVL5	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/510	13/18367	0.306636708513916	0.685732091299956	PPP1R14A	1
GO:0008195	phosphatidate phosphatase activity	1/510	13/18367	0.306636708513916	0.685732091299956	PLPP1	1
GO:0008253	5'-nucleotidase activity	1/510	13/18367	0.306636708513916	0.685732091299956	NT5DC2	1
GO:0015271	outward rectifier potassium channel activity	1/510	13/18367	0.306636708513916	0.685732091299956	PKD2	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/510	13/18367	0.306636708513916	0.685732091299956	NXN	1
GO:0031386	protein tag	1/510	13/18367	0.306636708513916	0.685732091299956	ISG15	1
GO:0031432	titin binding	1/510	13/18367	0.306636708513916	0.685732091299956	CALM2	1
GO:0045159	myosin II binding	1/510	13/18367	0.306636708513916	0.685732091299956	GSN	1
GO:0051011	microtubule minus-end binding	1/510	13/18367	0.306636708513916	0.685732091299956	MACF1	1
GO:0052650	NADP-retinol dehydrogenase activity	1/510	13/18367	0.306636708513916	0.685732091299956	DHRS3	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/510	13/18367	0.306636708513916	0.685732091299956	INPP4B	1
GO:0004857	enzyme inhibitor activity	3/510	70/18367	0.307811159300624	0.686009170728012	TXNIP/PPP1R12B/PPP1R12A	3
GO:0019001	guanyl nucleotide binding	13/510	398/18367	0.314248334787184	0.68877769316596	GUCY1A2/EHD2/PRKG1/TUBA1A/RAP2A/RRAS/RERG/ATL3/RHOQ/RHOB/RND3/ARL3/ARHGAP5	13
GO:0032561	guanyl ribonucleotide binding	13/510	398/18367	0.314248334787184	0.68877769316596	GUCY1A2/EHD2/PRKG1/TUBA1A/RAP2A/RRAS/RERG/ATL3/RHOQ/RHOB/RND3/ARL3/ARHGAP5	13
GO:0016859	cis-trans isomerase activity	2/510	41/18367	0.315764084879778	0.68877769316596	FKBP10/FKBP14	2
GO:0030331	estrogen receptor binding	2/510	41/18367	0.315764084879778	0.68877769316596	RERG/TACC1	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/510	41/18367	0.315764084879778	0.68877769316596	CLOCK/EPC1	2
GO:0031490	chromatin DNA binding	4/510	103/18367	0.320875641662542	0.68877769316596	ACTB/ACTN4/CLOCK/STAT3	4
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	3/510	72/18367	0.323080721966994	0.68877769316596	COX4I2/COX7A1/CYBRD1	3
GO:0030276	clathrin binding	3/510	72/18367	0.323080721966994	0.68877769316596	HIP1/STON1/EPN2	3
GO:0004065	arylsulfatase activity	1/510	14/18367	0.325903096149195	0.68877769316596	SULF2	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/510	14/18367	0.325903096149195	0.68877769316596	PIK3R1	1
GO:0031005	filamin binding	1/510	14/18367	0.325903096149195	0.68877769316596	SYNPO2	1
GO:0044548	S100 protein binding	1/510	14/18367	0.325903096149195	0.68877769316596	AHNAK	1
GO:0015036	disulfide oxidoreductase activity	2/510	42/18367	0.32602523741782	0.68877769316596	NXN/QSOX1	2
GO:0035064	methylated histone binding	3/510	73/18367	0.330717814893986	0.68877769316596	KMT2E/ZMYND11/ATRX	3
GO:0140034	methylation-dependent protein binding	3/510	73/18367	0.330717814893986	0.68877769316596	KMT2E/ZMYND11/ATRX	3
GO:0003924	GTPase activity	11/510	337/18367	0.33524993378721	0.68877769316596	TUBA1A/GNG11/RAP2A/RRAS/RERG/ATL3/RHOQ/RHOB/RND3/ARL3/ARHGAP5	11
GO:0005246	calcium channel regulator activity	2/510	43/18367	0.33624526749848	0.68877769316596	PRKG1/CALM2	2
GO:0016504	peptidase activator activity	2/510	43/18367	0.33624526749848	0.68877769316596	PCOLCE/CAV1	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/510	43/18367	0.33624526749848	0.68877769316596	HIP1/SH3PXD2A	2
GO:0005126	cytokine receptor binding	9/510	271/18367	0.339994975244977	0.68877769316596	PXDN/TGFB2/OSMR/IL6ST/FERMT2/JAK1/STAT3/PIK3R1/LIFR	9
GO:0004559	alpha-mannosidase activity	1/510	15/18367	0.344635151996408	0.68877769316596	MAN2A1	1
GO:0008252	nucleotidase activity	1/510	15/18367	0.344635151996408	0.68877769316596	NT5DC2	1
GO:0010851	cyclase regulator activity	1/510	15/18367	0.344635151996408	0.68877769316596	CALM2	1
GO:0017136	NAD-dependent histone deacetylase activity	1/510	15/18367	0.344635151996408	0.68877769316596	HDAC7	1
GO:0019215	intermediate filament binding	1/510	15/18367	0.344635151996408	0.68877769316596	VIM	1
GO:0030553	cGMP binding	1/510	15/18367	0.344635151996408	0.68877769316596	PRKG1	1
GO:0032794	GTPase activating protein binding	1/510	15/18367	0.344635151996408	0.68877769316596	ARL3	1
GO:0042043	neurexin family protein binding	1/510	15/18367	0.344635151996408	0.68877769316596	SYTL2	1
GO:0045125	bioactive lipid receptor activity	1/510	15/18367	0.344635151996408	0.68877769316596	LPAR1	1
GO:0070742	C2H2 zinc finger domain binding	1/510	15/18367	0.344635151996408	0.68877769316596	EBF1	1
GO:0051879	Hsp90 protein binding	2/510	44/18367	0.346418553644717	0.68877769316596	NR3C1/AHR	2
GO:0015631	tubulin binding	12/510	375/18367	0.349247848709734	0.68877769316596	CRYAB/MAP1B/DST/MAP9/MAP4K4/MAP4/DPYSL2/MAP1LC3A/CNN3/ARL3/MACF1/TAOK1	12
GO:0001618	virus receptor activity	3/510	76/18367	0.353602594456262	0.68877769316596	AXL/CD81/ITGB1	3
GO:0005525	GTP binding	12/510	377/18367	0.355932740303855	0.68877769316596	GUCY1A2/EHD2/TUBA1A/RAP2A/RRAS/RERG/ATL3/RHOQ/RHOB/RND3/ARL3/ARHGAP5	12
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2/510	45/18367	0.356539817018858	0.68877769316596	PEAK1/JAK1	2
GO:0140272	exogenous protein binding	3/510	77/18367	0.361212585510872	0.68877769316596	AXL/CD81/ITGB1	3
GO:0005092	GDP-dissociation inhibitor activity	1/510	16/18367	0.362847666843936	0.68877769316596	CHM	1
GO:0005283	amino acid:sodium symporter activity	1/510	16/18367	0.362847666843936	0.68877769316596	SLC38A2	1
GO:0008970	phospholipase A1 activity	1/510	16/18367	0.362847666843936	0.68877769316596	LIPG	1
GO:0015923	mannosidase activity	1/510	16/18367	0.362847666843936	0.68877769316596	MAN2A1	1
GO:0016208	AMP binding	1/510	16/18367	0.362847666843936	0.68877769316596	CYB5R3	1
GO:0019841	retinol binding	1/510	16/18367	0.362847666843936	0.68877769316596	RBP1	1
GO:0022841	potassium ion leak channel activity	1/510	16/18367	0.362847666843936	0.68877769316596	KCNK6	1
GO:0034979	NAD-dependent protein deacetylase activity	1/510	16/18367	0.362847666843936	0.68877769316596	HDAC7	1
GO:0036122	BMP binding	1/510	16/18367	0.362847666843936	0.68877769316596	BMPR2	1
GO:0042577	lipid phosphatase activity	1/510	16/18367	0.362847666843936	0.68877769316596	PLPP1	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/510	16/18367	0.362847666843936	0.68877769316596	PIK3R1	1
GO:0047498	calcium-dependent phospholipase A2 activity	1/510	16/18367	0.362847666843936	0.68877769316596	PLA2G2A	1
GO:0050135	NAD(P)+ nucleosidase activity	1/510	16/18367	0.362847666843936	0.68877769316596	IL1R1	1
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	1/510	16/18367	0.362847666843936	0.68877769316596	IL1R1	1
GO:0070492	oligosaccharide binding	1/510	16/18367	0.362847666843936	0.68877769316596	LGALS1	1
GO:0004864	protein phosphatase inhibitor activity	2/510	46/18367	0.366604106792967	0.689891878201173	PPP1R14A/PHACTR2	2
GO:0061980	regulatory RNA binding	2/510	46/18367	0.366604106792967	0.689891878201173	SOX4/KCNQ1OT1	2
GO:0140296	general transcription initiation factor binding	2/510	46/18367	0.366604106792967	0.689891878201173	TCF4/AHR	2
GO:0001221	transcription coregulator binding	3/510	78/18367	0.368808934890247	0.692046650814171	FOXO1/CTBP2/AHR	3
GO:0035254	glutamate receptor binding	2/510	47/18367	0.37660678606487	0.694140865685584	HIP1/PTEN	2
GO:0004659	prenyltransferase activity	1/510	17/18367	0.380555022841407	0.694140865685584	CHM	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/510	17/18367	0.380555022841407	0.694140865685584	PTPRA	1
GO:0008484	sulfuric ester hydrolase activity	1/510	17/18367	0.380555022841407	0.694140865685584	SULF2	1
GO:0015278	calcium-release channel activity	1/510	17/18367	0.380555022841407	0.694140865685584	PKD2	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/510	17/18367	0.380555022841407	0.694140865685584	CYBRD1	1
GO:0016854	racemase and epimerase activity	1/510	17/18367	0.380555022841407	0.694140865685584	DSEL	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/510	17/18367	0.380555022841407	0.694140865685584	PTPRA	1
GO:0030169	low-density lipoprotein particle binding	1/510	17/18367	0.380555022841407	0.694140865685584	THBS1	1
GO:0042800	histone methyltransferase activity (H3-K4 specific)	1/510	17/18367	0.380555022841407	0.694140865685584	KMT2A	1
GO:0048020	CCR chemokine receptor binding	2/510	48/18367	0.386543518300944	0.703100048608681	JAK1/STAT3	2
GO:0019212	phosphatase inhibitor activity	2/510	49/18367	0.396410254287324	0.711629032091588	PPP1R14A/PHACTR2	2
GO:0034212	peptide N-acetyltransferase activity	2/510	49/18367	0.396410254287324	0.711629032091588	CLOCK/EPC1	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/510	18/18367	0.397771204767886	0.711629032091588	SLC25A24	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/510	18/18367	0.397771204767886	0.711629032091588	PTEN	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/510	18/18367	0.397771204767886	0.711629032091588	SLC25A24	1
GO:0048038	quinone binding	1/510	18/18367	0.397771204767886	0.711629032091588	AOC3	1
GO:0042277	peptide binding	10/510	321/18367	0.400856518337097	0.71518936195116	CRYAB/RAMP1/TGFB2/HSPG2/MGST1/CRIP1/EDNRB/PIK3R1/GSTM3/KPNA3	10
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	2/510	50/18367	0.406203219571874	0.719880070681988	CCND2/CCNG2	2
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/510	50/18367	0.406203219571874	0.719880070681988	IL1R1/MAN2A1	2
GO:0001540	amyloid-beta binding	3/510	84/18367	0.413961904660822	0.719880070681988	CRYAB/TGFB2/HSPG2	3
GO:0000339	RNA cap binding	1/510	19/18367	0.414509810989935	0.719880070681988	EIF4G3	1
GO:0004745	NAD-retinol dehydrogenase activity	1/510	19/18367	0.414509810989935	0.719880070681988	DHRS3	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/510	19/18367	0.414509810989935	0.719880070681988	SH3PXD2A	1
GO:0016918	retinal binding	1/510	19/18367	0.414509810989935	0.719880070681988	RBP1	1
GO:0022840	leak channel activity	1/510	19/18367	0.414509810989935	0.719880070681988	KCNK6	1
GO:0022842	narrow pore channel activity	1/510	19/18367	0.414509810989935	0.719880070681988	KCNK6	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/510	19/18367	0.414509810989935	0.719880070681988	PTEN	1
GO:0008013	beta-catenin binding	3/510	85/18367	0.42139514700994	0.726878537129467	TCF4/FOXO1/VCL	3
GO:0050660	flavin adenine dinucleotide binding	3/510	85/18367	0.42139514700994	0.726878537129467	MAOA/QSOX1/CYB5R3	3
GO:0001972	retinoic acid binding	1/510	20/18367	0.430784064118076	0.726878537129467	NR2F2	1
GO:0003756	protein disulfide isomerase activity	1/510	20/18367	0.430784064118076	0.726878537129467	QSOX1	1
GO:0004551	nucleotide diphosphatase activity	1/510	20/18367	0.430784064118076	0.726878537129467	ENPP1	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	1/510	20/18367	0.430784064118076	0.726878537129467	QSOX1	1
GO:0030296	protein tyrosine kinase activator activity	1/510	20/18367	0.430784064118076	0.726878537129467	GAS6	1
GO:0031418	L-ascorbic acid binding	1/510	20/18367	0.430784064118076	0.726878537129467	PLOD2	1
GO:0031681	G-protein beta-subunit binding	1/510	20/18367	0.430784064118076	0.726878537129467	GNG11	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/510	20/18367	0.430784064118076	0.726878537129467	PIK3R1	1
GO:0061608	nuclear import signal receptor activity	1/510	20/18367	0.430784064118076	0.726878537129467	KPNA3	1
GO:0003727	single-stranded RNA binding	3/510	87/18367	0.436163714389105	0.727267467218366	ATXN1/RBMS3/RBPMS	3
GO:0015459	potassium channel regulator activity	2/510	54/18367	0.444570837254276	0.727267467218366	FLNA/CAV1	2
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/510	21/18367	0.446606821369931	0.727267467218366	LPGAT1	1
GO:0004407	histone deacetylase activity	1/510	21/18367	0.446606821369931	0.727267467218366	HDAC7	1
GO:0005243	gap junction channel activity	1/510	21/18367	0.446606821369931	0.727267467218366	GJC1	1
GO:0005385	zinc ion transmembrane transporter activity	1/510	21/18367	0.446606821369931	0.727267467218366	SLC39A6	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/510	21/18367	0.446606821369931	0.727267467218366	SLC25A24	1
GO:0015662	P-type ion transporter activity	1/510	21/18367	0.446606821369931	0.727267467218366	ATP2B4	1
GO:0051010	microtubule plus-end binding	1/510	21/18367	0.446606821369931	0.727267467218366	DST	1
GO:0070577	lysine-acetylated histone binding	1/510	21/18367	0.446606821369931	0.727267467218366	KMT2A	1
GO:0140033	acetylation-dependent protein binding	1/510	21/18367	0.446606821369931	0.727267467218366	KMT2A	1
GO:0140358	P-type transmembrane transporter activity	1/510	21/18367	0.446606821369931	0.727267467218366	ATP2B4	1
GO:0140416	transcription regulator inhibitor activity	1/510	21/18367	0.446606821369931	0.727267467218366	ID4	1
GO:1990381	ubiquitin-specific protease binding	1/510	21/18367	0.446606821369931	0.727267467218366	PTEN	1
GO:0005416	amino acid:cation symporter activity	1/510	22/18367	0.461990584648103	0.737603549572644	SLC38A2	1
GO:0005540	hyaluronic acid binding	1/510	22/18367	0.461990584648103	0.737603549572644	VCAN	1
GO:0008093	cytoskeletal anchor activity	1/510	22/18367	0.461990584648103	0.737603549572644	SORBS2	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/510	22/18367	0.461990584648103	0.737603549572644	DHRS3	1
GO:0008320	protein transmembrane transporter activity	1/510	22/18367	0.461990584648103	0.737603549572644	TOMM7	1
GO:0033558	protein deacetylase activity	1/510	22/18367	0.461990584648103	0.737603549572644	HDAC7	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/510	22/18367	0.461990584648103	0.737603549572644	GAS6	1
GO:0120020	cholesterol transfer activity	1/510	22/18367	0.461990584648103	0.737603549572644	TSPO	1
GO:0042826	histone deacetylase binding	4/510	127/18367	0.471028750359344	0.746874638495044	MYOCD/MEF2C/NCOR2/MEF2A	4
GO:0005248	voltage-gated sodium channel activity	1/510	23/18367	0.476947510340633	0.746874638495044	PKD2	1
GO:0017025	TBP-class protein binding	1/510	23/18367	0.476947510340633	0.746874638495044	AHR	1
GO:0030215	semaphorin receptor binding	1/510	23/18367	0.476947510340633	0.746874638495044	SEMA5A	1
GO:0030552	cAMP binding	1/510	23/18367	0.476947510340633	0.746874638495044	PRKAR1A	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/510	23/18367	0.476947510340633	0.746874638495044	LPGAT1	1
GO:0071617	lysophospholipid acyltransferase activity	1/510	23/18367	0.476947510340633	0.746874638495044	LPGAT1	1
GO:0120015	sterol transfer activity	1/510	23/18367	0.476947510340633	0.746874638495044	TSPO	1
GO:0030246	carbohydrate binding	8/510	271/18367	0.480633882151271	0.750846710633445	CD248/ENPP1/VCAN/LGALS1/CLEC11A/CD302/MAN2A1/PLOD2	8
GO:0031072	heat shock protein binding	4/510	129/18367	0.483114188592697	0.752920203224418	HSPA2/NR3C1/ZFP36/AHR	4
GO:0003707	steroid hormone receptor activity	1/510	24/18367	0.491489418851659	0.760527465663824	NR3C1	1
GO:0019789	SUMO transferase activity	1/510	24/18367	0.491489418851659	0.760527465663824	HDAC7	1
GO:0019957	C-C chemokine binding	1/510	24/18367	0.491489418851659	0.760527465663824	ZFP36	1
GO:0005104	fibroblast growth factor receptor binding	1/510	25/18367	0.505627803869686	0.775058581988039	NPTN	1
GO:0005242	inward rectifier potassium channel activity	1/510	25/18367	0.505627803869686	0.775058581988039	KCNK6	1
GO:0030247	polysaccharide binding	1/510	25/18367	0.505627803869686	0.775058581988039	ENPP1	1
GO:0034237	protein kinase A regulatory subunit binding	1/510	25/18367	0.505627803869686	0.775058581988039	PJA2	1
GO:0005507	copper ion binding	2/510	61/18367	0.508218413331685	0.777205208209813	AOC3/SOD3	2
GO:0004435	phosphatidylinositol phospholipase C activity	1/510	26/18367	0.519373841380669	0.78872353121297	EDNRA	1
GO:0004806	triglyceride lipase activity	1/510	26/18367	0.519373841380669	0.78872353121297	LIPG	1
GO:0099604	ligand-gated calcium channel activity	1/510	26/18367	0.519373841380669	0.78872353121297	PKD2	1
GO:0008139	nuclear localization sequence binding	1/510	27/18367	0.532738398432949	0.796059895141226	KPNA3	1
GO:0015215	nucleotide transmembrane transporter activity	1/510	27/18367	0.532738398432949	0.796059895141226	SLC25A24	1
GO:0015491	cation:cation antiporter activity	1/510	27/18367	0.532738398432949	0.796059895141226	SLC8A1	1
GO:0022884	macromolecule transmembrane transporter activity	1/510	27/18367	0.532738398432949	0.796059895141226	TOMM7	1
GO:0035255	ionotropic glutamate receptor binding	1/510	27/18367	0.532738398432949	0.796059895141226	PTEN	1
GO:0043425	bHLH transcription factor binding	1/510	27/18367	0.532738398432949	0.796059895141226	TCF12	1
GO:0045499	chemorepellent activity	1/510	27/18367	0.532738398432949	0.796059895141226	SEMA5A	1
GO:0003953	NAD+ nucleosidase activity	1/510	28/18367	0.545732041660822	0.806251183720626	IL1R1	1
GO:0004629	phospholipase C activity	1/510	28/18367	0.545732041660822	0.806251183720626	EDNRA	1
GO:0046875	ephrin receptor binding	1/510	28/18367	0.545732041660822	0.806251183720626	CHN1	1
GO:0050681	androgen receptor binding	1/510	28/18367	0.545732041660822	0.806251183720626	TGFB1I1	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/510	28/18367	0.545732041660822	0.806251183720626	HIP1	1
GO:0004620	phospholipase activity	3/510	104/18367	0.554686696866541	0.813866907945174	PLA2G2A/EDNRA/LIPG	3
GO:0033218	amide binding	11/510	400/18367	0.556078170169999	0.813866907945174	CRYAB/RAMP1/TGFB2/FKBP10/HSPG2/MGST1/CRIP1/EDNRB/PIK3R1/GSTM3/KPNA3	11
GO:0004033	aldo-keto reductase (NADP) activity	1/510	29/18367	0.558365045573412	0.813866907945174	DHRS3	1
GO:0004181	metallocarboxypeptidase activity	1/510	29/18367	0.558365045573412	0.813866907945174	CPXM1	1
GO:0051787	misfolded protein binding	1/510	29/18367	0.558365045573412	0.813866907945174	HSPA2	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/510	29/18367	0.558365045573412	0.813866907945174	SH3PXD2A	1
GO:0042578	phosphoric ester hydrolase activity	10/510	366/18367	0.565708202845954	0.815388955364923	EDNRA/PDE3A/PDE8B/ENPP1/PLPP1/INPP4B/NT5DC2/PPM1K/PTEN/PTPRA	10
GO:0008080	N-acetyltransferase activity	2/510	68/18367	0.566916688400246	0.815388955364923	CLOCK/EPC1	2
GO:0140375	immune receptor activity	4/510	144/18367	0.569740355552955	0.815388955364923	OSMR/IL1R1/IL6ST/LIFR	4
GO:0005217	intracellular ligand-gated ion channel activity	1/510	30/18367	0.570647400615268	0.815388955364923	PKD2	1
GO:0005343	organic acid:sodium symporter activity	1/510	30/18367	0.570647400615268	0.815388955364923	SLC38A2	1
GO:0017147	Wnt-protein binding	1/510	30/18367	0.570647400615268	0.815388955364923	CTHRC1	1
GO:0022829	wide pore channel activity	1/510	30/18367	0.570647400615268	0.815388955364923	GJC1	1
GO:0046966	thyroid hormone receptor binding	1/510	30/18367	0.570647400615268	0.815388955364923	TACC1	1
GO:0070566	adenylyltransferase activity	1/510	30/18367	0.570647400615268	0.815388955364923	PAPSS2	1
GO:0001664	G protein-coupled receptor binding	8/510	295/18367	0.576998032509479	0.818333647908215	AGTR1/CTHRC1/WNT2/FLNA/EDNRB/ARHGEF12/JAK1/STAT3	8
GO:0016411	acylglycerol O-acyltransferase activity	1/510	31/18367	0.582588821004983	0.818333647908215	LPGAT1	1
GO:0071813	lipoprotein particle binding	1/510	31/18367	0.582588821004983	0.818333647908215	THBS1	1
GO:0071814	protein-lipid complex binding	1/510	31/18367	0.582588821004983	0.818333647908215	THBS1	1
GO:0140142	nucleocytoplasmic carrier activity	1/510	31/18367	0.582588821004983	0.818333647908215	KPNA3	1
GO:0140318	protein transporter activity	1/510	31/18367	0.582588821004983	0.818333647908215	TOMM7	1
GO:0001098	basal transcription machinery binding	2/510	70/18367	0.58273376152729	0.818333647908215	TCF4/AHR	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/510	70/18367	0.58273376152729	0.818333647908215	TCF4/AHR	2
GO:0008528	G protein-coupled peptide receptor activity	4/510	147/18367	0.586079837878968	0.821266382263876	AGTR1/EDNRA/RAMP1/EDNRB	4
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/510	71/18367	0.59048128673497	0.822058867139242	HDAC7/GLS	2
GO:0008047	enzyme activator activity	3/510	110/18367	0.592840157414478	0.822058867139242	PPP1R12B/SH3PXD2A/CALM2	3
GO:0001222	transcription corepressor binding	1/510	32/18367	0.594198752357921	0.822058867139242	CTBP2	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/510	32/18367	0.594198752357921	0.822058867139242	SLC25A24	1
GO:0031624	ubiquitin conjugating enzyme binding	1/510	32/18367	0.594198752357921	0.822058867139242	ZMYM2	1
GO:0048019	receptor antagonist activity	1/510	32/18367	0.594198752357921	0.822058867139242	PXDN	1
GO:0003678	DNA helicase activity	2/510	72/18367	0.598121302871198	0.822228541486797	CHD9/ATRX	2
GO:0042379	chemokine receptor binding	2/510	72/18367	0.598121302871198	0.822228541486797	JAK1/STAT3	2
GO:0140677	molecular function activator activity	4/510	150/18367	0.602053711907966	0.822228541486797	PPP1R12B/SH3PXD2A/CALM2/BMPR2	4
GO:0004623	phospholipase A2 activity	1/510	33/18367	0.605486379098988	0.822228541486797	PLA2G2A	1
GO:0005154	epidermal growth factor receptor binding	1/510	33/18367	0.605486379098988	0.822228541486797	HIP1	1
GO:0051427	hormone receptor binding	1/510	33/18367	0.605486379098988	0.822228541486797	JAK1	1
GO:0070063	RNA polymerase binding	2/510	73/18367	0.605653795490275	0.822228541486797	ZFP36/STOM	2
GO:0106306	protein serine phosphatase activity	2/510	73/18367	0.605653795490275	0.822228541486797	PPM1K/PTEN	2
GO:0106307	protein threonine phosphatase activity	2/510	73/18367	0.605653795490275	0.822228541486797	PPM1K/PTEN	2
GO:0015020	glucuronosyltransferase activity	1/510	34/18367	0.616460631671231	0.833317626754684	EXT1	1
GO:0045505	dynein intermediate chain binding	1/510	34/18367	0.616460631671231	0.833317626754684	DYNLT3	1
GO:0001653	peptide receptor activity	4/510	153/18367	0.617650430856458	0.833317626754684	AGTR1/EDNRA/RAMP1/EDNRB	4
GO:0015298	solute:cation antiporter activity	1/510	35/18367	0.627130193545866	0.844362920382372	SLC8A1	1
GO:0015248	sterol transporter activity	1/510	36/18367	0.63750350803919	0.854804498459119	TSPO	1
GO:0061631	ubiquitin conjugating enzyme activity	1/510	36/18367	0.63750350803919	0.854804498459119	UBE2E3	1
GO:0030971	receptor tyrosine kinase binding	2/510	78/18367	0.641708494665333	0.858356701585437	GAS6/PIK3R1	2
GO:0016853	isomerase activity	4/510	158/18367	0.64278166474009	0.858356701585437	FKBP10/DSEL/QSOX1/FKBP14	4
GO:0042056	chemoattractant activity	1/510	37/18367	0.647588784941705	0.8612535164296	HGF	1
GO:0046915	transition metal ion transmembrane transporter activity	1/510	37/18367	0.647588784941705	0.8612535164296	SLC39A6	1
GO:0140030	modification-dependent protein binding	4/510	160/18367	0.652525709776119	0.866055464397979	KMT2E/ZMYND11/ATRX/KMT2A	4
GO:0015175	neutral amino acid transmembrane transporter activity	1/510	38/18367	0.657394006964604	0.867228861712901	SLC38A2	1
GO:0019213	deacetylase activity	1/510	38/18367	0.657394006964604	0.867228861712901	HDAC7	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/510	38/18367	0.657394006964604	0.867228861712901	ZMYM2	1
GO:0005179	hormone activity	3/510	122/18367	0.662538775595355	0.872253670289853	METRN/IGF2/FBN1	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/510	39/18367	0.666926936008635	0.876264163407724	UBE2E3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3/510	124/18367	0.673274490294284	0.879592455930166	UGDH/CTBP2/DHRS3	3
GO:0031492	nucleosomal DNA binding	1/510	40/18367	0.67619511926025	0.879592455930166	ACTB	1
GO:0042287	MHC protein binding	1/510	40/18367	0.67619511926025	0.879592455930166	CD81	1
GO:0043014	alpha-tubulin binding	1/510	40/18367	0.67619511926025	0.879592455930166	TAOK1	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/510	40/18367	0.67619511926025	0.879592455930166	GAS6	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/510	125/18367	0.678547452016445	0.880897586812601	DDAH2/HDAC7/GLS	3
GO:0009055	electron transfer activity	3/510	126/18367	0.683757218550841	0.885899729590673	COX4I2/COX7A1/DHRS3	3
GO:0048487	beta-tubulin binding	1/510	41/18367	0.685205895119761	0.886018711907335	TAOK1	1
GO:0001046	core promoter sequence-specific DNA binding	1/510	42/18367	0.693966398966151	0.892047359300977	NR3C1	1
GO:0019894	kinesin binding	1/510	42/18367	0.693966398966151	0.892047359300977	ACTB	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/510	42/18367	0.693966398966151	0.892047359300977	REV3L	1
GO:0016298	lipase activity	3/510	129/18367	0.699008326289198	0.895940957816872	PLA2G2A/EDNRA/LIPG	3
GO:0004180	carboxypeptidase activity	1/510	43/18367	0.702483568763	0.895940957816872	CPXM1	1
GO:0018024	histone-lysine N-methyltransferase activity	1/510	43/18367	0.702483568763	0.895940957816872	KMT2A	1
GO:0030547	signaling receptor inhibitor activity	1/510	43/18367	0.702483568763	0.895940957816872	PXDN	1
GO:0051219	phosphoprotein binding	2/510	88/18367	0.705947979920391	0.898604348709582	PKD2/PIK3R1	2
GO:0001784	phosphotyrosine residue binding	1/510	44/18367	0.710764150509936	0.899060629998279	PIK3R1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/510	44/18367	0.710764150509936	0.899060629998279	DYRK2	1
GO:0008375	acetylglucosaminyltransferase activity	1/510	44/18367	0.710764150509936	0.899060629998279	EXT1	1
GO:0051117	ATPase binding	2/510	89/18367	0.711813699401394	0.899060629998279	CAV1/PKD2	2
GO:0016779	nucleotidyltransferase activity	3/510	132/18367	0.71369523579999	0.899696889917747	PAPSS2/REV3L/POLK	3
GO:0005249	voltage-gated potassium channel activity	2/510	90/18367	0.717581196423889	0.902665387334842	KCNK6/PKD2	2
GO:0005245	voltage-gated calcium channel activity	1/510	45/18367	0.718814703543825	0.902665387334842	PKD2	1
GO:0016407	acetyltransferase activity	2/510	91/18367	0.723251390935775	0.906493585952133	CLOCK/EPC1	2
GO:0005272	sodium channel activity	1/510	46/18367	0.726641605693844	0.907001347573468	PKD2	1
GO:0015085	calcium ion transmembrane transporter activity	3/510	135/18367	0.727823439706734	0.907001347573468	SLC8A1/ATP2B4/PKD2	3
GO:0043177	organic acid binding	3/510	135/18367	0.727823439706734	0.907001347573468	NR2F2/DDAH2/PLOD2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3/510	136/18367	0.732409873167762	0.908079433837673	UGDH/CTBP2/DHRS3	3
GO:0005044	scavenger receptor activity	1/510	47/18367	0.734251058294473	0.908079433837673	ENPP1	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	1/510	47/18367	0.734251058294473	0.908079433837673	PTEN	1
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/510	47/18367	0.734251058294473	0.908079433837673	ATP2B4	1
GO:0016410	N-acyltransferase activity	2/510	94/18367	0.739687716946021	0.913073873659266	CLOCK/EPC1	2
GO:0120013	lipid transfer activity	1/510	48/18367	0.741649091060293	0.913767653702588	TSPO	1
GO:0015399	primary active transmembrane transporter activity	4/510	181/18367	0.743929381654641	0.914851009831414	COX4I2/COX7A1/CYBRD1/ATP2B4	4
GO:0045182	translation regulator activity	3/510	140/18367	0.75014889323408	0.920765464815516	EIF4G3/EIF4EBP1/EIF4EBP2	3
GO:0008170	N-methyltransferase activity	2/510	97/18367	0.755283580370592	0.920820379778458	NNMT/KMT2A	2
GO:0005048	signal sequence binding	1/510	50/18367	0.755834186158122	0.920820379778458	KPNA3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/510	50/18367	0.755834186158122	0.920820379778458	SLC25A24	1
GO:0030159	signaling receptor complex adaptor activity	1/510	50/18367	0.755834186158122	0.920820379778458	PIK3R1	1
GO:0004722	protein serine/threonine phosphatase activity	2/510	98/18367	0.760300240558069	0.923931386210387	PPM1K/PTEN	2
GO:0003743	translation initiation factor activity	1/510	51/18367	0.762632491833689	0.923931386210387	EIF4G3	1
GO:0016860	intramolecular oxidoreductase activity	1/510	51/18367	0.762632491833689	0.923931386210387	QSOX1	1
GO:0008146	sulfotransferase activity	1/510	52/18367	0.769241873203246	0.928493425511497	DSEL	1
GO:0016597	amino acid binding	1/510	52/18367	0.769241873203246	0.928493425511497	DDAH2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/510	53/18367	0.775667570427726	0.934521999057758	SLC25A24	1
GO:0016791	phosphatase activity	6/510	275/18367	0.779036780513421	0.935147042355914	PLPP1/INPP4B/NT5DC2/PPM1K/PTEN/PTPRA	6
GO:0004725	protein tyrosine phosphatase activity	2/510	102/18367	0.77948551142465	0.935147042355914	PTEN/PTPRA	2
GO:0008374	O-acyltransferase activity	1/510	54/18367	0.78191467860081	0.935147042355914	LPGAT1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/510	54/18367	0.78191467860081	0.935147042355914	PLOD2	1
GO:0005125	cytokine activity	5/510	235/18367	0.78486145173501	0.936480908563553	WNT2/TIMP1/TGFB2/BMP1/CMTM3	5
GO:0106310	protein serine kinase activity	8/510	360/18367	0.78589822035655	0.936480908563553	DYRK2/CDC42BPA/HIPK2/MAP4K4/ROCK2/MAP4K5/TAOK1/AKT3	8
GO:0004869	cysteine-type endopeptidase inhibitor activity	1/510	56/18367	0.793892806770548	0.940856629439506	GAS6	1
GO:0042054	histone methyltransferase activity	1/510	56/18367	0.793892806770548	0.940856629439506	KMT2A	1
GO:0045309	protein phosphorylated amino acid binding	1/510	56/18367	0.793892806770548	0.940856629439506	PIK3R1	1
GO:0015081	sodium ion transmembrane transporter activity	3/510	152/18367	0.797747064029248	0.943711653643295	SLC8A1/SLC38A2/PKD2	3
GO:0051087	chaperone binding	2/510	107/18367	0.801566055948947	0.946514709827599	HSPB6/HSPA2	2
GO:0016279	protein-lysine N-methyltransferase activity	1/510	59/18367	0.810640053136274	0.955184285022628	KMT2A	1
GO:0004386	helicase activity	3/510	156/18367	0.81183350411571	0.955184285022628	CHD9/DDX17/ATRX	3
GO:0016278	lysine N-methyltransferase activity	1/510	60/18367	0.81591499157305	0.958259873196406	KMT2A	1
GO:0008094	ATP-dependent activity, acting on DNA	2/510	111/18367	0.817796165703595	0.958744876489134	CHD9/ATRX	2
GO:0015179	L-amino acid transmembrane transporter activity	1/510	61/18367	0.821043267877073	0.959107788772323	SLC38A2	1
GO:0043621	protein self-association	1/510	61/18367	0.821043267877073	0.959107788772323	ATXN1	1
GO:0099094	ligand-gated cation channel activity	2/510	113/18367	0.825457601398376	0.961327439924617	KCNK6/PKD2	2
GO:1990841	promoter-specific chromatin binding	1/510	62/18367	0.826028951990625	0.961327439924617	EGR1	1
GO:0016746	acyltransferase activity	5/510	250/18367	0.827359910011692	0.961327439924617	LPGAT1/CLOCK/ELOVL5/ACLY/EPC1	5
GO:0030145	manganese ion binding	1/510	65/18367	0.840169478323492	0.97447721020469	DYRK2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	1/510	68/18367	0.853162719394709	0.982706970625848	DSEL	1
GO:0051536	iron-sulfur cluster binding	1/510	68/18367	0.853162719394709	0.982706970625848	REV3L	1
GO:0051540	metal cluster binding	1/510	68/18367	0.853162719394709	0.982706970625848	REV3L	1
GO:0005267	potassium channel activity	2/510	121/18367	0.853284613085537	0.982706970625848	KCNK6/PKD2	2
GO:0031491	nucleosome binding	1/510	71/18367	0.865101591702408	0.987441866652559	ACTB	1
GO:0048029	monosaccharide binding	1/510	71/18367	0.865101591702408	0.987441866652559	PLOD2	1
GO:0004721	phosphoprotein phosphatase activity	3/510	174/18367	0.865342470016606	0.987441866652559	PPM1K/PTEN/PTPRA	3
GO:0000287	magnesium ion binding	4/510	221/18367	0.865787124451454	0.987441866652559	RAP2A/DYRK2/CDC42BPA/ARL3	4
GO:0022853	active ion transmembrane transporter activity	5/510	267/18367	0.867026724515392	0.987441866652559	COX4I2/COX7A1/SLC8A1/ATP2B4/SLC38A2	5
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4/510	222/18367	0.868061265110113	0.987441866652559	LPGAT1/CLOCK/ELOVL5/EPC1	4
GO:0008235	metalloexopeptidase activity	1/510	72/18367	0.868861877460594	0.987441866652559	CPXM1	1
GO:0015370	solute:sodium symporter activity	1/510	73/18367	0.872517545265737	0.987441866652559	SLC38A2	1
GO:0033293	monocarboxylic acid binding	1/510	73/18367	0.872517545265737	0.987441866652559	NR2F2	1
GO:0140104	molecular carrier activity	1/510	73/18367	0.872517545265737	0.987441866652559	KPNA3	1
GO:0005254	chloride channel activity	1/510	74/18367	0.876071500218972	0.989228073044066	FXYD1	1
GO:0016887	ATP hydrolysis activity	5/510	272/18367	0.877125657415795	0.989228073044066	HSPA2/CHD9/ATP2B4/DDX17/ATRX	5
GO:0015078	proton transmembrane transporter activity	2/510	130/18367	0.879715394155659	0.990438193764906	COX4I2/COX7A1	2
GO:0140097	catalytic activity, acting on DNA	4/510	229/18367	0.883071755237828	0.992505776540966	CHD9/REV3L/POLK/ATRX	4
GO:0003724	RNA helicase activity	1/510	77/18367	0.886150944534902	0.992549857257789	DDX17	1
GO:0038024	cargo receptor activity	1/510	77/18367	0.886150944534902	0.992549857257789	ENPP1	1
GO:0008186	ATP-dependent activity, acting on RNA	1/510	79/18367	0.892411747618116	0.996145078965179	DDX17	1
GO:0034987	immunoglobulin receptor binding	1/510	79/18367	0.892411747618116	0.996145078965179	FLNA	1
GO:0004527	exonuclease activity	1/510	80/18367	0.895412076178634	0.997788542226362	ENPP1	1
GO:0020037	heme binding	2/510	139/18367	0.901690306931885	0.999771942450002	GUCY1A2/PXDN	2
GO:0008135	translation factor activity, RNA binding	1/510	84/18367	0.906601159756449	0.999771942450002	EIF4G3	1
GO:0015171	amino acid transmembrane transporter activity	1/510	84/18367	0.906601159756449	0.999771942450002	SLC38A2	1
GO:0015276	ligand-gated ion channel activity	2/510	143/18367	0.910203583836627	0.999771942450002	KCNK6/PKD2	2
GO:0022834	ligand-gated channel activity	2/510	143/18367	0.910203583836627	0.999771942450002	KCNK6/PKD2	2
GO:0022843	voltage-gated cation channel activity	2/510	143/18367	0.910203583836627	0.999771942450002	KCNK6/PKD2	2
GO:0042393	histone binding	4/510	244/18367	0.910316259530233	0.999771942450002	KMT2E/ZMYND11/ATRX/KMT2A	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	2/510	144/18367	0.912221464319807	0.999771942450002	IL1R1/MAN2A1	2
GO:0005253	anion channel activity	1/510	87/18367	0.914201581371824	0.999771942450002	FXYD1	1
GO:0008276	protein methyltransferase activity	1/510	88/18367	0.916595300928737	0.999771942450002	KMT2A	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/510	88/18367	0.916595300928737	0.999771942450002	CYB5R3	1
GO:0052689	carboxylic ester hydrolase activity	2/510	147/18367	0.918023088410936	0.999771942450002	PLA2G2A/LIPG	2
GO:0015297	antiporter activity	1/510	89/18367	0.918922364582456	0.999771942450002	SLC8A1	1
GO:0019842	vitamin binding	2/510	148/18367	0.91987558647206	0.999771942450002	RBP1/PLOD2	2
GO:0003730	mRNA 3'-UTR binding	3/510	201/18367	0.920573053034719	0.999771942450002	RBMS3/ZFP36L1/ZFP36	3
GO:0046906	tetrapyrrole binding	2/510	149/18367	0.921688682013631	0.999771942450002	GUCY1A2/PXDN	2
GO:0043130	ubiquitin binding	1/510	92/18367	0.925521890257014	0.999983079154255	HSPB1	1
GO:0051213	dioxygenase activity	1/510	92/18367	0.925521890257014	0.999983079154255	PLOD2	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	1/510	94/18367	0.929620915071063	0.999983079154255	MAN2A1	1
GO:0005319	lipid transporter activity	2/510	154/18367	0.930189123657128	0.999983079154255	APOD/TSPO	2
GO:0015079	potassium ion transmembrane transporter activity	2/510	155/18367	0.931781246659924	0.999983079154255	KCNK6/PKD2	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/510	156/18367	0.933339009550108	0.999983079154255	NNMT/KMT2A	2
GO:0008238	exopeptidase activity	1/510	103/18367	0.945452205395932	0.999983079154255	CPXM1	1
GO:0015294	solute:cation symporter activity	1/510	104/18367	0.946975386257083	0.999983079154255	SLC38A2	1
GO:0016741	transferase activity, transferring one-carbon groups	3/510	225/18367	0.951393203622945	0.999983079154255	GATM/NNMT/KMT2A	3
GO:0090079	translation regulator activity, nucleic acid binding	1/510	108/18367	0.952655236656062	0.999983079154255	EIF4G3	1
GO:0042626	ATPase-coupled transmembrane transporter activity	1/510	109/18367	0.95397764365017	0.999983079154255	ATP2B4	1
GO:0000149	SNARE binding	1/510	110/18367	0.955263184330333	0.999983079154255	SEC24D	1
GO:0030594	neurotransmitter receptor activity	1/510	111/18367	0.956512884499667	0.999983079154255	TSPO	1
GO:0032182	ubiquitin-like protein binding	1/510	111/18367	0.956512884499667	0.999983079154255	HSPB1	1
GO:0031406	carboxylic acid binding	2/510	176/18367	0.958241671130507	0.999983079154255	NR2F2/PLOD2	2
GO:0004197	cysteine-type endopeptidase activity	1/510	119/18367	0.96533427762565	0.999983079154255	CTSK	1
GO:0005262	calcium channel activity	1/510	119/18367	0.96533427762565	0.999983079154255	PKD2	1
GO:0008514	organic anion transmembrane transporter activity	2/510	185/18367	0.966277109850738	0.999983079154255	SLC38A2/SLC25A24	2
GO:0003697	single-stranded DNA binding	1/510	123/18367	0.969050498268107	0.999983079154255	SMC6	1
GO:0022804	active transmembrane transporter activity	6/510	406/18367	0.971131515092416	0.999983079154255	COX4I2/COX7A1/CYBRD1/SLC8A1/ATP2B4/SLC38A2	6
GO:0004519	endonuclease activity	1/510	129/18367	0.973892623394713	0.999983079154255	ENDOD1	1
GO:0016829	lyase activity	2/510	196/18367	0.974092639913758	0.999983079154255	GUCY1A2/ADCY3	2
GO:0005244	voltage-gated ion channel activity	2/510	201/18367	0.977037551675198	0.999983079154255	KCNK6/PKD2	2
GO:0022832	voltage-gated channel activity	2/510	201/18367	0.977037551675198	0.999983079154255	KCNK6/PKD2	2
GO:0046873	metal ion transmembrane transporter activity	6/510	430/18367	0.981162078253044	0.999983079154255	KCNK6/SLC8A1/ATP2B4/SLC39A6/SLC38A2/PKD2	6
GO:0004518	nuclease activity	2/510	210/18367	0.98154303829837	0.999983079154255	ENPP1/ENDOD1	2
GO:0008194	UDP-glycosyltransferase activity	1/510	143/18367	0.982450841057597	0.999983079154255	EXT1	1
GO:0015293	symporter activity	1/510	144/18367	0.982941955580239	0.999983079154255	SLC38A2	1
GO:0008168	methyltransferase activity	2/510	214/18367	0.983258570615178	0.999983079154255	NNMT/KMT2A	2
GO:0005506	iron ion binding	1/510	151/18367	0.986016349535504	0.999983079154255	PLOD2	1
GO:0015103	inorganic anion transmembrane transporter activity	1/510	152/18367	0.986407854900946	0.999983079154255	FXYD1	1
GO:0046943	carboxylic acid transmembrane transporter activity	1/510	163/18367	0.990055464004163	0.999983079154255	SLC38A2	1
GO:0005342	organic acid transmembrane transporter activity	1/510	164/18367	0.990334068341555	0.999983079154255	SLC38A2	1
GO:0015291	secondary active transmembrane transporter activity	2/510	240/18367	0.991178303450934	0.999983079154255	SLC8A1/SLC38A2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/510	170/18367	0.991849496225837	0.999983079154255	PLOD2	1
GO:0003823	antigen binding	1/510	171/18367	0.992077927116908	0.999983079154255	SPON2	1
GO:0008509	anion transmembrane transporter activity	3/510	314/18367	0.993102438694427	0.999983079154255	FXYD1/SLC38A2/SLC25A24	3
GO:0003735	structural constituent of ribosome	1/510	182/18367	0.994205825338711	0.999983079154255	ISG15	1
GO:0008234	cysteine-type peptidase activity	1/510	190/18367	0.995385323949524	0.999983079154255	CTSK	1
GO:0019787	ubiquitin-like protein transferase activity	5/510	458/18367	0.996133151486509	0.999983079154255	TTC3/RNF145/HDAC7/PJA2/UBE2E3	5
GO:0016758	hexosyltransferase activity	1/510	197/18367	0.996218962851731	0.999983079154255	EXT1	1
GO:0005216	ion channel activity	4/510	432/18367	0.99808585570002	0.999983079154255	GJC1/FXYD1/KCNK6/PKD2	4
GO:0004842	ubiquitin-protein transferase activity	4/510	433/18367	0.998128116732738	0.999983079154255	TTC3/RNF145/PJA2/UBE2E3	4
GO:0005261	cation channel activity	2/510	335/18367	0.999212593296855	0.999983079154255	KCNK6/PKD2	2
GO:0022836	gated channel activity	2/510	340/18367	0.99930841885626	0.999983079154255	KCNK6/PKD2	2
GO:0015267	channel activity	4/510	480/18367	0.999354833099598	0.999983079154255	GJC1/FXYD1/KCNK6/PKD2	4
GO:0022803	passive transmembrane transporter activity	4/510	481/18367	0.999369491929086	0.999983079154255	GJC1/FXYD1/KCNK6/PKD2	4
GO:0016757	glycosyltransferase activity	1/510	270/18367	0.999528802043521	0.999983079154255	EXT1	1
GO:0061630	ubiquitin protein ligase activity	1/510	304/18367	0.99982188170668	0.999983079154255	RNF145	1
GO:0061659	ubiquitin-like protein ligase activity	1/510	316/18367	0.999873700959795	0.999983079154255	RNF145	1
GO:0140098	catalytic activity, acting on RNA	1/510	386/18367	0.999983079154255	0.999983079154255	DDX17	1