ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003779	actin binding	66/1005	440/18367	6.81167876568857e-14	4.32567053997108e-11	SPTBN1/ABLIM1/PLS3/FSCN1/ABLIM3/SHROOM4/CEACAM1/PDLIM4/MARCKSL1/HIP1/MSN/PARVB/MARCKS/PHACTR2/PRKCE/MACF1/SPTAN1/DIXDC1/VASH1/SHROOM1/ITGB1/FGD4/TMSB4X/DST/SNTB2/UTRN/FLNB/LASP1/ACTN4/KLHL5/PDLIM5/PDLIM7/LIMCH1/TMSB10/MYH9/TMOD3/TPM3/PALLD/CNN3/TNS1/FLNA/RDX/MYO10/ACTR2/CALD1/FERMT2/PHACTR4/FXYD5/VCL/CTTN/MYO1C/ENC1/ADD1/CTNNA1/CCDC88A/IQGAP1/TPM4/PLEC/MYO9A/GSN/WASL/DAAM1/PTK2/COBLL1/DSTN/MTSS1	66
GO:0019838	growth factor binding	34/1005	141/18367	1.34548161036418e-13	4.32567053997108e-11	A2M/IGFBP4/KDR/ACVRL1/TEK/KL/COL3A1/LRRC32/CD109/HYAL2/COL4A1/LIFR/ENG/BMPR2/FGFR1/IL1R1/THBS1/OSMR/TGFBR2/LTBP1/IGFBP7/NRP1/PDGFB/CRIM1/DUSP1/SHC1/IL6ST/IGFBP3/CD36/ITGA6/SDCBP/HTRA1/S100A13/LTBP3	34
GO:0045296	cadherin binding	55/1005	332/18367	1.440289857926e-13	4.32567053997108e-11	CDH5/SPTBN1/PTPRB/KDR/STXBP6/SLC9A3R2/FSCN1/DCHS1/PKP4/BMPR2/MACF1/SPTAN1/TJP1/ITGB1/PHLDB2/FLNB/LASP1/KIF5B/PDLIM5/CTNND1/KTN1/MYH9/TMOD3/CNN3/FLNA/RDX/ITGA6/CALD1/PTPRM/NDRG1/DOCK9/AHNAK/PKN2/FXYD5/ZC3HAV1/EHD4/VCL/RTN4/CTTN/ADD1/ARGLU1/CTNNA1/IQGAP1/PICALM/PAK2/F11R/PLEC/CD46/SH3GLB1/DDX6/EIF4G2/HNRNPK/HSPA1A/COBLL1/YWHAB	55
GO:0046332	SMAD binding	23/1005	79/18367	1.90987451611221e-11	4.30199234754276e-09	ACVRL1/SMAD6/FKBP1A/TGFBR2/SKIL/RGCC/SMAD5/SMAD1/MEF2A/SMURF2/HIPK2/PML/FLNA/SKI/TCF12/FERMT2/PURA/ZMIZ1/SMAD2/PURB/SMAD4/JUN/SAV1	23
GO:0005178	integrin binding	29/1005	144/18367	8.59831984848247e-10	1.54941723669654e-07	VWF/JAM2/KDR/IGF1/ICAM2/COL3A1/ITGA2/FN1/ADAM15/THBS1/LAMB2/IGF2/ITGB1/DST/CD81/UTRN/ACTN4/JAM3/PLPP3/MYH9/ISG15/TSPAN4/FERMT2/ADAM10/EMP2/CD9/F11R/CD151/PTK2	29
GO:0005096	GTPase activator activity	58/1005	462/18367	2.87434218675714e-09	3.83199554918782e-07	ARHGAP29/RAPGEF5/RGS5/PREX2/FGD5/ARHGEF15/RALGAPA2/RASA4/SH3BP5/RGS3/PLCB1/DLC1/ARHGEF12/FGD4/DOCK4/ASAP2/ELMO1/ARHGAP28/NRP1/PLEKHG1/ARHGAP31/GIT1/ADRB1/GNAQ/ITSN2/RIN2/TBC1D4/RGL2/GDI1/RASAL2/RANBP2/SBF2/TBC1D15/CYTH1/ACAP2/DOCK9/STARD13/RAPGEF2/CCDC88A/ARHGAP5/IQGAP1/ARHGEF7/SEC23A/NUCB1/CHM/MYO9A/ARHGEF3/ARFGEF3/GIT2/RALGAPB/SOS2/SOS1/BNIP2/DOCK1/ARHGAP17/JUN/RAP1A/HERC2	58
GO:0030695	GTPase regulator activity	60/1005	488/18367	3.40243777952304e-09	3.83199554918782e-07	ARHGAP29/RAPGEF5/RGS5/PREX2/FGD5/ARHGEF15/RALGAPA2/RASA4/SH3BP5/RGS3/PLCB1/DLC1/ARHGEF12/FGD4/DOCK4/ASAP2/ELMO1/ARHGAP28/NRP1/PLEKHG1/ARHGAP31/GIT1/ADRB1/GNAQ/ITSN2/RIN2/TBC1D4/RGL2/GDI1/RASAL2/RANBP2/SBF2/TBC1D15/CYTH1/ACAP2/DOCK9/STARD13/RAPGEF2/CCDC88A/ARHGAP5/IQGAP1/ARHGEF7/SEC23A/NUCB1/CHM/MYO9A/ARHGEF3/ARFGEF3/GIT2/ARL2BP/RALGAPB/WASL/SOS2/SOS1/BNIP2/DOCK1/ARHGAP17/JUN/RAP1A/HERC2	60
GO:0060589	nucleoside-triphosphatase regulator activity	60/1005	488/18367	3.40243777952304e-09	3.83199554918782e-07	ARHGAP29/RAPGEF5/RGS5/PREX2/FGD5/ARHGEF15/RALGAPA2/RASA4/SH3BP5/RGS3/PLCB1/DLC1/ARHGEF12/FGD4/DOCK4/ASAP2/ELMO1/ARHGAP28/NRP1/PLEKHG1/ARHGAP31/GIT1/ADRB1/GNAQ/ITSN2/RIN2/TBC1D4/RGL2/GDI1/RASAL2/RANBP2/SBF2/TBC1D15/CYTH1/ACAP2/DOCK9/STARD13/RAPGEF2/CCDC88A/ARHGAP5/IQGAP1/ARHGEF7/SEC23A/NUCB1/CHM/MYO9A/ARHGEF3/ARFGEF3/GIT2/ARL2BP/RALGAPB/WASL/SOS2/SOS1/BNIP2/DOCK1/ARHGAP17/JUN/RAP1A/HERC2	60
GO:0019955	cytokine binding	25/1005	139/18367	1.2930581466917e-07	1.29449487796581e-05	A2M/ACVRL1/LEPR/LRRC32/CD109/FZD4/HYAL2/LIFR/ENG/BMPR2/IL1R1/THBS1/OSMR/TGFBR2/ITGB1/LTBP1/NRP1/IL13RA1/IL6ST/TNFRSF14/CD36/ZFP36/IFNAR1/TNFRSF1B/LTBP3	25
GO:0034713	type I transforming growth factor beta receptor binding	7/1005	10/18367	1.49291862963058e-07	1.34511968529715e-05	SMAD6/ENG/FKBP1A/TGFBR2/TGFB1/FERMT2/SMAD2	7
GO:0050431	transforming growth factor beta binding	10/1005	24/18367	2.2332960186117e-07	1.82927246615376e-05	ACVRL1/LRRC32/CD109/HYAL2/ENG/THBS1/TGFBR2/LTBP1/CD36/LTBP3	10
GO:0044389	ubiquitin-like protein ligase binding	41/1005	316/18367	2.51379257384606e-07	1.88743925752942e-05	FZD4/SMAD6/FOXO1/SYT11/TXNIP/SMAD5/CLU/RB1/JAK1/PML/PRKAR1A/CCDC50/SLF2/TRIB2/ATXN3/TNFRSF14/ISG15/ABI2/HIF1A/SKI/TMBIM6/RALB/PCBP2/PARP9/SPOP/VCL/RTN4/FZD6/APC/TNFRSF1B/CRK/SMAD2/ATF6/RALA/DTX3L/PRKAR2A/HSPA1A/PIAS1/BCL10/JUN/HERC2	41
GO:0031625	ubiquitin protein ligase binding	39/1005	297/18367	3.59891783889848e-07	2.49432690219041e-05	FZD4/SMAD6/FOXO1/SYT11/TXNIP/SMAD5/CLU/RB1/JAK1/PML/PRKAR1A/CCDC50/SLF2/TRIB2/ATXN3/TNFRSF14/ISG15/ABI2/HIF1A/SKI/TMBIM6/RALB/PCBP2/SPOP/VCL/RTN4/FZD6/APC/TNFRSF1B/CRK/SMAD2/ATF6/RALA/PRKAR2A/HSPA1A/PIAS1/BCL10/JUN/HERC2	39
GO:0005518	collagen binding	16/1005	69/18367	7.06714912824544e-07	4.54821526039224e-05	SPARCL1/VWF/SPARC/ITGA2/FN1/ADGRG6/ITGA1/NID1/THBS1/ITGB1/PDGFB/SERPINH1/HSD17B12/CD44/CRTAP/SMAD4	16
GO:0140297	DNA-binding transcription factor binding	46/1005	394/18367	1.0298891760931e-06	6.18620098439922e-05	IFI27/TCF15/MEF2C/HHEX/FOXP1/LMO2/HDAC7/MTDH/MEF2A/ACTN4/MDFIC/HIPK2/RB1/PKN1/KLF4/GTF2I/NCOA7/HIF1A/SKI/TCF12/TACC1/CREB1/PURA/STAT3/PARP9/SPEN/TBX3/CREM/MED13/CTBP2/SMAD2/ETS2/DTX3L/ATF2/HES1/TRIP12/STRN/PURB/JMJD1C/ID2/SMAD4/ARID1A/BCL10/BAZ2A/JUN/BHLHE40	46
GO:0051015	actin filament binding	30/1005	217/18367	2.74740378642751e-06	0.000154713175723199	SPTBN1/ABLIM1/PLS3/FSCN1/ABLIM3/SHROOM4/MARCKSL1/HIP1/MARCKS/MACF1/SPTAN1/SHROOM1/UTRN/FLNB/LASP1/ACTN4/MYH9/TPM3/FLNA/MYO10/ACTR2/FERMT2/CTTN/MYO1C/ADD1/CTNNA1/IQGAP1/TPM4/GSN/DSTN	30
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	49/1005	450/18367	3.4584904144944e-06	0.000183299991968203	TCF4/NFIB/MEOX2/ELK3/NFIA/SOX18/FLI1/ERG/HOXA13/ZNF521/MECOM/TCF15/FOXF1/MEF2C/HHEX/FOXO1/EPAS1/ETS1/PLAGL1/SMAD1/MEF2A/ELK4/VEZF1/ZNF770/KLF4/NFIC/GTF2I/GABPA/NFAT5/HIF1A/TCF12/CREB1/STAT3/GATA2/KLF6/EGR1/PLSCR1/TBX3/CLOCK/ELF1/SMAD2/ATF6/KLF10/ATF2/NR3C1/CREBRF/REL/SMAD4/JUN	49
GO:0001216	DNA-binding transcription activator activity	49/1005	456/18367	5.00194382633807e-06	0.000250375077085033	TCF4/NFIB/MEOX2/ELK3/NFIA/SOX18/FLI1/ERG/HOXA13/ZNF521/MECOM/TCF15/FOXF1/MEF2C/HHEX/FOXO1/EPAS1/ETS1/PLAGL1/SMAD1/MEF2A/ELK4/VEZF1/ZNF770/KLF4/NFIC/GTF2I/GABPA/NFAT5/HIF1A/TCF12/CREB1/STAT3/GATA2/KLF6/EGR1/PLSCR1/TBX3/CLOCK/ELF1/SMAD2/ATF6/KLF10/ATF2/NR3C1/CREBRF/REL/SMAD4/JUN	49
GO:0005201	extracellular matrix structural constituent	25/1005	172/18367	7.51012773104967e-06	0.00033023988680924	VWF/SPARC/MGP/COL15A1/MMRN1/MMRN2/LAMA4/COL3A1/HMCN1/COL18A1/MATN2/LAMA2/HSPG2/COL4A1/FN1/TFPI2/AGRN/COL4A2/NID1/THBS1/LAMB2/LTBP1/IGFBP7/LAMC1/EFEMP1	25
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	36/1005	299/18367	7.60508036372829e-06	0.00033023988680924	IFI27/FOXP1/LMO2/MTDH/MEF2A/ACTN4/MDFIC/HIPK2/RB1/PKN1/KLF4/GTF2I/NCOA7/HIF1A/TACC1/CREB1/STAT3/PARP9/SPEN/TBX3/MED13/CTBP2/ETS2/DTX3L/ATF2/HES1/TRIP12/STRN/JMJD1C/ID2/SMAD4/ARID1A/BCL10/BAZ2A/JUN/BHLHE40	36
GO:0004674	protein serine/threonine kinase activity	43/1005	386/18367	7.69704508656385e-06	0.00033023988680924	ACVRL1/NUAK1/RPS6KA2/ENG/BMPR2/CDC42BPA/PRKCE/SNRK/MAP4K2/TGFBR2/PRKD3/LTBP1/RPS6KA3/HIPK2/CDK6/MAP3K3/PKN1/PRKCH/CDK17/TAOK1/AKT3/MAP3K11/MAP4K4/EIF2AK2/HIPK3/PKN2/HIPK1/CSNK1A1/PIM3/PAK2/MAP4K5/PRKAA1/WNK1/CDC42BPB/NEK7/ROCK2/MAST4/SMG1/DYRK1A/ROCK1/MAPK1/PLK2/CSNK1G3	43
GO:0019902	phosphatase binding	27/1005	196/18367	9.12600997202514e-06	0.000373751590217939	CDH5/SLC9A3R2/CEACAM1/PDLIM4/FOXO1/ITGA1/PXN/JAK1/AKAP11/CTTNBP2NL/PPP2R2A/SBF2/ARPP19/HSP90B1/PHACTR4/STAT3/PPP3R1/ATP2B4/IQGAP1/CDC27/SHOC2/SMAD2/WNK1/STRN/PTK2/MAPK1/KIFAP3	27
GO:0001618	virus receptor activity	15/1005	76/18367	1.30368052544071e-05	0.000510702675400903	ITGA2/HYAL2/EFNB2/ITGA5/SCARB1/ITGB1/CD81/SCARB2/LAMP1/TNFRSF14/PLSCR1/F11R/XPR1/CD46/HSPA1A	15
GO:0098631	cell adhesion mediator activity	13/1005	59/18367	1.40623913504931e-05	0.00052792560861643	ESAM/STXBP6/ROBO4/ITGA2/ITGA1/ITGB1/PDLIM5/JAM3/CD200/TMOD3/PALLD/CNN3/NPTN	13
GO:0140272	exogenous protein binding	15/1005	77/18367	1.53820269596608e-05	0.000554368251626176	ITGA2/HYAL2/EFNB2/ITGA5/SCARB1/ITGB1/CD81/SCARB2/LAMP1/TNFRSF14/PLSCR1/F11R/XPR1/CD46/HSPA1A	15
GO:0140678	molecular function inhibitor activity	20/1005	128/18367	2.05805633707132e-05	0.000713195676808176	SMAD6/FRY/CAV1/ITPR1/ID3/TXNIP/ID1/NOTCH1/FNIP2/CALM1/TMBIM6/PURA/SLC30A1/PARP9/WNK1/DTX3L/ID2/NEDD4/PPP1R12A/OAZ2	20
GO:0048156	tau protein binding	11/1005	45/18367	2.26959603267922e-05	0.000757372602016289	CLU/TAOK1/FYN/PPP2R2A/PICALM/PPP2CB/PRKAA1/SMAD2/ROCK2/DYRK1A/ROCK1	11
GO:0051020	GTPase binding	34/1005	291/18367	2.54156750433069e-05	0.000817840114786413	SPTBN1/BICD1/FGD5/RASIP1/CDC42EP5/CAV1/FGD4/DOCK4/HACE1/NCKAP1/PKN1/IPO11/EXOC5/GNB1/MAP3K11/GDI1/FLNA/ABI2/RANBP2/NDRG1/PKN2/ABCA1/TNFAIP1/MYO1C/IQGAP1/PICALM/PAK2/CHM/CDC42BPB/ROCK2/ROCK1/DAAM1/XPO1/RAP1A	34
GO:0003712	transcription coregulator activity	49/1005	489/18367	3.23612253551016e-05	0.00100542979465333	LDB2/HYAL2/WWTR1/LMCD1/ETS1/LMO2/HDAC7/NOTCH1/MTDH/PXN/BCOR/ACTN4/DDX17/HIPK2/RB1/PKN1/N4BP2L2/PARP14/NCOA7/ZMYND11/KDM7A/MED13L/TACC1/RYBP/ZMIZ1/PARP9/SPEN/TBL1XR1/RSF1/IRF2BP2/CCND1/MED13/EID1/PTPN14/TRIM13/ATF7IP/CTBP2/KAT6A/MAML2/ARL2BP/DYRK1A/CNOT2/JMJD1C/HSPA1A/PIAS1/BTG2/ARID1A/BCL10/PSIP1	49
GO:0005085	guanyl-nucleotide exchange factor activity	28/1005	223/18367	3.57703624371504e-05	0.00103214410283453	RAPGEF5/PREX2/FGD5/ARHGEF15/SH3BP5/ARHGEF12/FGD4/DOCK4/ELMO1/PLEKHG1/ADRB1/ITSN2/RIN2/RGL2/SBF2/CYTH1/DOCK9/RAPGEF2/CCDC88A/ARHGEF7/NUCB1/ARHGEF3/ARFGEF3/SOS2/SOS1/DOCK1/RAP1A/HERC2	28
GO:0031267	small GTPase binding	31/1005	259/18367	3.58638193593457e-05	0.00103214410283453	BICD1/FGD5/CDC42EP5/CAV1/FGD4/DOCK4/HACE1/NCKAP1/PKN1/IPO11/EXOC5/MAP3K11/GDI1/FLNA/ABI2/RANBP2/NDRG1/PKN2/ABCA1/TNFAIP1/MYO1C/IQGAP1/PICALM/PAK2/CHM/CDC42BPB/ROCK2/ROCK1/DAAM1/XPO1/RAP1A	31
GO:0005160	transforming growth factor beta receptor binding	8/1005	25/18367	3.66577261828025e-05	0.00103214410283453	SMAD6/ENG/FKBP1A/TGFBR2/SMURF2/TGFB1/FERMT2/SMAD2	8
GO:0106310	protein serine kinase activity	39/1005	360/18367	3.78122890085979e-05	0.00103239007262869	NUAK1/RPS6KA2/CDC42BPA/PRKCE/SNRK/MAP4K2/PRKD3/RPS6KA3/HIPK2/CDK6/MAP3K3/PKN1/PRKCH/CDK17/TAOK1/AKT3/PIK3CA/MAP3K11/MAP4K4/EIF2AK2/HIPK3/PKN2/HIPK1/CSNK1A1/PIM3/PAK2/MAP4K5/PRKAA1/WNK1/CDC42BPB/NEK7/ROCK2/MAST4/SMG1/DYRK1A/ROCK1/MAPK1/PLK2/CSNK1G3	39
GO:0050840	extracellular matrix binding	12/1005	56/18367	4.02562902679573e-05	0.00106679169210087	SPARCL1/SPARC/CLEC14A/ITGA2/THSD1/AGRN/ADGRG6/NID1/THBS1/ITGB1/LGALS1/ITGA6	12
GO:0019903	protein phosphatase binding	21/1005	150/18367	6.89288047885687e-05	0.00177442437470001	CDH5/CEACAM1/PDLIM4/FOXO1/ITGA1/PXN/JAK1/AKAP11/CTTNBP2NL/PPP2R2A/ARPP19/HSP90B1/PHACTR4/STAT3/ATP2B4/IQGAP1/CDC27/SHOC2/STRN/PTK2/KIFAP3	21
GO:0019207	kinase regulator activity	28/1005	233/18367	7.83689756508343e-05	0.00196140130726116	LRP6/HYAL2/BMPR2/SH3BP5/IGF2/RGCC/PIK3R3/PKIG/CCNY/SOCS3/CALM1/TAOK1/PRKAR1A/PIK3CA/TRIB2/KLF4/APC/IQGAP1/SOCS4/CCND1/PAK2/CCNI/WNK1/PRKAR2A/BCL10/MOB1A/CCNT1/YWHAB	28
GO:0017124	SH3 domain binding	19/1005	130/18367	8.38213755881571e-05	0.0020411637677008	PLSCR4/SH3BP5/ADAM15/DOCK4/ELMO1/ARHGAP31/GJA1/SH3BGRL/ABI2/QKI/ADAM10/PLSCR1/SH3BGRL2/CBLB/CRK/SOS1/DOCK1/ARHGAP17/PTPN12	19
GO:0043236	laminin binding	8/1005	28/18367	9.09693580745972e-05	0.00215693135855821	ITGA2/AGRN/ADGRG6/NID1/THBS1/ITGB1/LGALS1/ITGA6	8
GO:1990782	protein tyrosine kinase binding	16/1005	105/18367	0.000181871310689108	0.00420169361361247	CDH5/CEACAM1/GRB14/HYAL2/BMPR2/ANGPT2/ANGPT1/NEDD9/SH2B3/ITGB1/DOCK4/SHC1/PTEN/PTPN14/CBLB/CRK	16
GO:0004697	protein kinase C activity	6/1005	17/18367	0.000194188127533481	0.00437408757269166	PRKCE/PRKD3/PKN1/PRKCH/PKN2/SMG1	6
GO:0070851	growth factor receptor binding	19/1005	141/18367	0.000249064220383153	0.00534628865897229	CDH5/KL/VEGFC/ITGA5/HIP1/IL1R1/PDGFB/APP/YES1/ERAP1/SHC1/IL6ST/FYN/PTEN/SDCBP/NPTN/PLSCR1/CCDC88A/EFEMP1	19
GO:0003925	G protein activity	9/1005	40/18367	0.000249216563459308	0.00534628865897229	RAB27A/RHOA/RALB/RALA/RAB11A/NRAS/CDC42/RAB5A/RAP1A	9
GO:0098632	cell-cell adhesion mediator activity	10/1005	49/18367	0.000268420105939961	0.00557398691500884	ESAM/STXBP6/ROBO4/PDLIM5/JAM3/CD200/TMOD3/PALLD/CNN3/NPTN	10
GO:0031435	mitogen-activated protein kinase kinase kinase binding	6/1005	18/18367	0.000277850343440178	0.00557398691500884	MAP4K2/TGFBR2/SASH1/MAP3K11/CDC42/MAPK1	6
GO:0005024	transforming growth factor beta-activated receptor activity	5/1005	12/18367	0.000278390023502106	0.00557398691500884	ACVRL1/ENG/BMPR2/TGFBR2/LTBP1	5
GO:0060090	molecular adaptor activity	37/1005	369/18367	0.00028594251389561	0.00560074358739011	SLC9A3R2/FSCN1/BICD1/GRB14/SORBS2/CAV1/HIP1/MAGI1/CAV2/SH2B3/AP1S2/SASH1/SERINC1/SHC1/ITSN2/STX3/GNB1/GNB4/MYH9/AP2B1/KLF4/ABI2/SUN1/SDCBP/STAT3/RB1CC1/SNAP23/FEM1B/WWC2/IQGAP1/SPAG9/DCAF7/DLGAP4/WWC3/CRK/APPBP2/SAV1	37
GO:0072542	protein phosphatase activator activity	5/1005	13/18367	0.000432047269419627	0.00828243807972519	PPP2R5A/CALM1/IGFBP3/PHACTR4/PPP2R5E	5
GO:0019211	phosphatase activator activity	6/1005	20/18367	0.000527941920557971	0.00990990980047358	BMPR2/PPP2R5A/CALM1/IGFBP3/PHACTR4/PPP2R5E	6
GO:0097718	disordered domain specific binding	8/1005	36/18367	0.000599878339922712	0.0110304160055176	FN1/RB1/CALM1/GJA1/FYN/GJA5/SMAD2/HSPA1A	8
GO:0046875	ephrin receptor binding	7/1005	28/18367	0.000617769906558606	0.0111322137161861	EFNB2/ANKS1A/EFNB1/SHC1/FYN/SDCBP/CRK	7
GO:0070411	I-SMAD binding	5/1005	14/18367	0.000641903927934781	0.0113403027268478	SMAD6/SMAD5/SMAD1/SMAD2/SMAD4	5
GO:0019208	phosphatase regulator activity	15/1005	107/18367	0.000711386999032526	0.0123261478101597	BMPR2/PHACTR2/RCAN1/PPP2R5A/CALM1/PPP2R2A/IGFBP3/SBF2/ARPP19/PHACTR4/EIF2AK2/PPP3R1/SHOC2/PPP2R5E/PPP1R12A	15
GO:0042277	peptide binding	32/1005	321/18367	0.000789287585734425	0.0132291671968155	RAMP2/FCGR2B/CALCRL/CRHBP/LEPR/RAMP3/ECE1/FZD4/ITGA2/NPR1/HSPG2/ITM2A/PCSK5/SCARB1/HLA-E/HLA-A/HLA-B/ITM2B/HLA-C/CLU/MGST2/ERAP1/KPNA3/AP2B1/CD36/LNPEP/NKTR/TAPBP/PPP3R1/PICALM/PPP3CA/SEC61A1	32
GO:0019887	protein kinase regulator activity	23/1005	204/18367	0.000813594865063933	0.0132291671968155	HYAL2/BMPR2/SH3BP5/IGF2/RGCC/PKIG/CCNY/SOCS3/CALM1/TAOK1/PRKAR1A/PIK3CA/TRIB2/APC/IQGAP1/CCND1/PAK2/CCNI/WNK1/PRKAR2A/MOB1A/CCNT1/YWHAB	23
GO:0019199	transmembrane receptor protein kinase activity	18/1005	143/18367	0.00081936908545485	0.0132291671968155	KDR/ACVRL1/TIE1/TEK/ENG/BMPR2/FGFR1/TGFBR2/LTBP1/NRP1/CRIM1/YES1/JAK1/FYN/EIF2AK2/EFEMP1/DYRK1A/PTK2	18
GO:0045309	protein phosphorylated amino acid binding	10/1005	56/18367	0.000822234587149464	0.0132291671968155	SHE/PIK3R3/YES1/SOCS3/SHC1/CBLB/CRK/MAPK1/NEDD4/YWHAB	10
GO:0030674	protein-macromolecule adaptor activity	30/1005	296/18367	0.000869802970211841	0.0137489908098398	SLC9A3R2/FSCN1/BICD1/GRB14/SORBS2/CAV1/HIP1/CAV2/SH2B3/AP1S2/SERINC1/SHC1/STX3/GNB1/GNB4/MYH9/AP2B1/KLF4/ABI2/SUN1/SDCBP/STAT3/SNAP23/FEM1B/IQGAP1/SPAG9/DCAF7/CRK/APPBP2/SAV1	30
GO:0051371	muscle alpha-actinin binding	5/1005	15/18367	0.000919695004777741	0.0141268752625554	PDLIM4/PDLIM5/PDLIM7/PALLD/PKD2	5
GO:0050321	tau-protein kinase activity	6/1005	22/18367	0.000925067303541365	0.0141268752625554	TAOK1/FYN/PRKAA1/ROCK2/DYRK1A/ROCK1	6
GO:0070888	E-box binding	9/1005	48/18367	0.0010320396570268	0.0154977955163525	TCF4/ZEB1/TCF15/AHR/HIF1A/TCF12/CLOCK/HES1/BHLHE40	9
GO:0004713	protein tyrosine kinase activity	17/1005	136/18367	0.00122127586284836	0.0180388451217439	KDR/TIE1/TEK/FGFR1/PEAK1/NRP1/CRIM1/HIPK2/YES1/JAK1/FYN/EIF2AK2/HIPK3/HIPK1/EFEMP1/DYRK1A/PTK2	17
GO:0004698	calcium-dependent protein kinase C activity	5/1005	16/18367	0.00127785988886611	0.0182754247598153	PRKCE/PRKD3/PKN1/PRKCH/PKN2	5
GO:0035497	cAMP response element binding	5/1005	16/18367	0.00127785988886611	0.0182754247598153	TCF12/CREB1/ATF6/ATF2/JUN	5
GO:0004721	phosphoprotein phosphatase activity	20/1005	174/18367	0.0013675268228564	0.0192522135530253	PTPRB/PPP2R5A/PPM1F/DUSP1/DUSP6/CDC25B/PTEN/MTMR6/PTPRM/PTPRG/CTDSP2/PPP3R1/PTP4A2/PPP2CB/PPP3CA/PTPN14/CTDSP1/PTPRA/PTPN12/CTDSPL2	20
GO:0003714	transcription corepressor activity	21/1005	187/18367	0.00141270999088759	0.0195806739939106	WWTR1/LMCD1/HDAC7/BCOR/HIPK2/RB1/N4BP2L2/PARP14/ZMYND11/RYBP/PARP9/SPEN/TBL1XR1/IRF2BP2/CCND1/EID1/ATF7IP/CTBP2/HSPA1A/PIAS1/BTG2	21
GO:0016303	1-phosphatidylinositol-3-kinase activity	4/1005	10/18367	0.00143432240132975	0.0195806739939106	PIK3R3/PIK3CA/PIK3C2B/PIK3C2A	4
GO:0008022	protein C-terminus binding	21/1005	189/18367	0.00161413549830427	0.0217065087160022	TCF4/SLC9A3R2/HSPG2/FN1/MAGI1/ID1/DST/MPDZ/SASH1/PABPC1/KPNA3/SDCBP/MYO1C/PPP2CB/PRKAA1/NIPBL/FOXN3/PIAS1/BCL10/VPS36/YWHAB	21
GO:0030169	low-density lipoprotein particle binding	5/1005	17/18367	0.00172938978942137	0.0229144147098331	SCARF1/SCARB1/THBS1/STAB1/CD36	5
GO:0035035	histone acetyltransferase binding	6/1005	25/18367	0.00190761693146249	0.0249096065977928	ETS1/MEF2A/CREB1/EGR1/EID1/KANSL1	6
GO:0030165	PDZ domain binding	12/1005	84/18367	0.0019964036997603	0.0256965676212004	ARHGAP29/TMEM88/FZD4/DOCK4/CRIM1/ADRB1/GJA1/PTEN/RAPGEF2/ATP2B4/F11R/CLCN3	12
GO:0003725	double-stranded RNA binding	11/1005	74/18367	0.00219581976458358	0.027865262082955	VIM/MSN/MTDH/DDX60/DICER1/MBNL1/OAS2/EIF2AK2/ADAR/RC3H1/ZFR	11
GO:0001784	phosphotyrosine residue binding	8/1005	44/18367	0.00238545925970784	0.029851372124955	SHE/PIK3R3/YES1/SOCS3/SHC1/CBLB/CRK/MAPK1	8
GO:0051393	alpha-actinin binding	6/1005	27/18367	0.0029038680825499	0.0357101594474805	PDLIM4/MAGI1/PDLIM5/PDLIM7/PALLD/PKD2	6
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	5/1005	19/18367	0.00296634943957181	0.0357101594474805	ACVRL1/ENG/BMPR2/TGFBR2/LTBP1	5
GO:0051219	phosphoprotein binding	12/1005	88/18367	0.00297254379418539	0.0357101594474805	SHE/PIK3R3/RB1/YES1/SOCS3/SHC1/PKD2/CBLB/CRK/MAPK1/NEDD4/YWHAB	12
GO:0038024	cargo receptor activity	11/1005	77/18367	0.00302541138014748	0.0358670480725379	LRP6/CFI/LOXL2/SCARF1/ENPP2/SCARB1/STAB1/SCARB2/CD36/ABCA1/CD320	11
GO:0035004	phosphatidylinositol 3-kinase activity	4/1005	12/18367	0.00309595121113056	0.0362266498860862	PIK3R3/PIK3CA/PIK3C2B/PIK3C2A	4
GO:0019888	protein phosphatase regulator activity	12/1005	89/18367	0.00326890284819748	0.0377600187977683	PHACTR2/RCAN1/PPP2R5A/CALM1/PPP2R2A/IGFBP3/ARPP19/PHACTR4/EIF2AK2/PPP3R1/SHOC2/PPP2R5E	12
GO:0001221	transcription coregulator binding	11/1005	78/18367	0.00335208353898426	0.0382307249193015	FOXO1/EPAS1/LMO2/AHR/KLF4/HIF1A/ZNF644/CREB1/CTBP2/CNOT2/SMAD4	11
GO:0005044	scavenger receptor activity	8/1005	47/18367	0.00366282198332317	0.0412525325871772	CFI/LOXL2/SCARF1/ENPP2/SCARB1/STAB1/SCARB2/CD36	8
GO:0031690	adrenergic receptor binding	5/1005	20/18367	0.00377915194590975	0.0420372333736381	PDE4D/ADRB1/RAPGEF2/NEDD4/SAV1	5
GO:0005520	insulin-like growth factor binding	6/1005	29/18367	0.00424502319146758	0.0464602117496436	IGFBP4/IGFBP7/CRIM1/IGFBP3/ITGA6/HTRA1	6
GO:0045159	myosin II binding	4/1005	13/18367	0.00427990851855763	0.0464602117496436	SHROOM4/SHROOM1/LIMCH1/GSN	4
GO:0140416	transcription regulator inhibitor activity	5/1005	21/18367	0.00473977800721707	0.0508397617202688	SMAD6/ID3/ID1/PURA/ID2	5
GO:0019209	kinase activator activity	13/1005	107/18367	0.00559908107731548	0.0593502594195441	BMPR2/IGF2/RGCC/CCNY/CALM1/TAOK1/PIK3CA/IQGAP1/PAK2/WNK1/BCL10/MOB1A/CCNT1	13
GO:0005172	vascular endothelial growth factor receptor binding	4/1005	14/18367	0.00573511035480678	0.0600852840660571	CDH5/VEGFC/ITGA5/CCDC88A	4
GO:0001540	amyloid-beta binding	11/1005	84/18367	0.00595171602148727	0.0606940152064385	FCGR2B/RAMP3/FZD4/ITGA2/HSPG2/ITM2A/SCARB1/ITM2B/CLU/CD36/PICALM	11
GO:0071813	lipoprotein particle binding	6/1005	31/18367	0.00599530227899337	0.0606940152064385	SCARF1/SCARB1/THBS1/STAB1/CD36/ABCA1	6
GO:0071814	protein-lipid complex binding	6/1005	31/18367	0.00599530227899337	0.0606940152064385	SCARF1/SCARB1/THBS1/STAB1/CD36/ABCA1	6
GO:0044325	transmembrane transporter binding	15/1005	133/18367	0.00615200068904755	0.0615883624536871	CDH5/CAV1/PDE4D/FKBP1A/ACTN4/YES1/CALM1/FYN/PDE4B/ITPR2/FLNA/NPTN/PKD2/CRBN/ID2	15
GO:0008013	beta-catenin binding	11/1005	85/18367	0.00650770241412916	0.064163168707147	TCF4/CDH5/SLC9A3R2/FOXO1/PXN/GJA1/KLF4/VCL/CTNNA1/APC/TBL1XR1	11
GO:0017022	myosin binding	10/1005	74/18367	0.00684675705006444	0.064163168707147	SHROOM4/SHROOM1/LIMCH1/RAB27A/RHOA/CALD1/MYL12B/GSN/RALA/RAB11A	10
GO:0019210	kinase inhibitor activity	10/1005	74/18367	0.00684675705006444	0.064163168707147	LRP6/HYAL2/SH3BP5/PKIG/SOCS3/PRKAR1A/TRIB2/WNK1/PRKAR2A/YWHAB	10
GO:0001223	transcription coactivator binding	6/1005	32/18367	0.00704410926984159	0.064163168707147	FOXO1/EPAS1/AHR/HIF1A/CREB1/SMAD4	6
GO:0071889	14-3-3 protein binding	6/1005	32/18367	0.00704410926984159	0.064163168707147	PRKCE/HDAC7/ZFP36L1/TMCC3/ZFP36/PPP1R12A	6
GO:0005158	insulin receptor binding	5/1005	23/18367	0.00715830229646292	0.064163168707147	IGF1/IGF2/SHC1/CCDC88A/PHIP	5
GO:0008143	poly(A) binding	5/1005	23/18367	0.00715830229646292	0.064163168707147	RBMS3/PABPC1/RBMS1/RBMS2/TIA1	5
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5/1005	23/18367	0.00715830229646292	0.064163168707147	PRKCE/PRKD3/PKN1/PRKCH/PKN2	5
GO:0030552	cAMP binding	5/1005	23/18367	0.00715830229646292	0.064163168707147	PDE4D/PRKAR1A/PDE4B/RAPGEF2/PRKAR2A	5
GO:0070412	R-SMAD binding	5/1005	23/18367	0.00715830229646292	0.064163168707147	SMAD6/RGCC/SMAD2/SMAD4/JUN	5
GO:0005516	calmodulin binding	20/1005	201/18367	0.00719254166417519	0.064163168707147	SPTBN1/CEACAM1/MARCKSL1/PLCB1/MARCKS/SPTAN1/TJP1/SNTB2/MYH9/CNN3/MYO10/CALD1/MYO1C/PPP3R1/ATP2B4/ADD1/IQGAP1/PPP3CA/STRN/CAMSAP2	20
GO:0005161	platelet-derived growth factor receptor binding	4/1005	15/18367	0.00748617048209005	0.0648561500419532	ITGA5/IL1R1/PDGFB/PTEN	4
GO:0005545	1-phosphatidylinositol binding	4/1005	15/18367	0.00748617048209005	0.0648561500419532	SCARB1/WDFY1/PICALM/WDFY3	4
GO:0048185	activin binding	4/1005	15/18367	0.00748617048209005	0.0648561500419532	ACVRL1/ENG/FKBP1A/TGFBR2	4
GO:0005126	cytokine receptor binding	25/1005	271/18367	0.00756990126147331	0.0649569622532139	CDH5/VEGFC/TNFSF10/LIFR/SMAD6/ENG/ITGA5/FKBP1A/OSMR/SH2B3/TGFBR2/SMURF2/IL13RA1/JAK1/ERAP1/SHC1/IL6ST/TGFB1/CFLAR/FERMT2/SDCBP/STAT3/FEM1B/CCDC88A/SMAD2	25
GO:0005154	epidermal growth factor receptor binding	6/1005	33/18367	0.00821941207218688	0.0692120586639288	HIP1/YES1/SHC1/PLSCR1/CCDC88A/EFEMP1	6
GO:0008200	ion channel inhibitor activity	6/1005	33/18367	0.00821941207218688	0.0692120586639288	CAV1/ITPR1/CALM1/SLC30A1/WNK1/NEDD4	6
GO:0010857	calcium-dependent protein kinase activity	5/1005	24/18367	0.00864225108266216	0.0720987798655427	PRKCE/PRKD3/PKN1/PRKCH/PKN2	5
GO:0030295	protein kinase activator activity	12/1005	101/18367	0.00904961771751647	0.0742648345081258	BMPR2/IGF2/RGCC/CCNY/CALM1/TAOK1/PIK3CA/IQGAP1/PAK2/WNK1/MOB1A/CCNT1	12
GO:0043178	alcohol binding	11/1005	89/18367	0.00914916385172249	0.0742648345081258	CAV1/ITPR1/PRKCE/CD81/SCARB2/OSBPL10/ITPR2/ABCA1/STARD4/XPR1/STARD3NL	11
GO:0051117	ATPase binding	11/1005	89/18367	0.00914916385172249	0.0742648345081258	CAV1/PDE4D/DNAJC10/ATXN3/RDX/RALB/PKD2/ABCA1/PPP3CA/RALA/ATOX1	11
GO:0016248	channel inhibitor activity	6/1005	34/18367	0.00952911349459419	0.0755228264841644	CAV1/ITPR1/CALM1/SLC30A1/WNK1/NEDD4	6
GO:0005159	insulin-like growth factor receptor binding	4/1005	16/18367	0.00955560734649805	0.0755228264841644	IGF1/IGF2/SHC1/CRK	4
GO:0005521	lamin binding	4/1005	16/18367	0.00955560734649805	0.0755228264841644	IFI27/PLCB1/SUN1/LBR	4
GO:0004725	protein tyrosine phosphatase activity	12/1005	102/18367	0.00976139304003333	0.0764783924266959	PTPRB/DUSP1/DUSP6/CDC25B/PTEN/MTMR6/PTPRM/PTPRG/PTP4A2/PTPN14/PTPRA/PTPN12	12
GO:0030971	receptor tyrosine kinase binding	10/1005	78/18367	0.00986529679633564	0.0766261414956759	GRB14/HYAL2/ANGPT2/ANGPT1/SH2B3/DOCK4/SHC1/PTPN14/CBLB/CRK	10
GO:0008266	poly(U) RNA binding	5/1005	25/18367	0.0103259096204621	0.0788444454918333	RBMS3/PABPC1/RBMS1/RBMS2/HNRNPH1	5
GO:0035925	mRNA 3'-UTR AU-rich region binding	5/1005	25/18367	0.0103259096204621	0.0788444454918333	RBMS3/ZFP36L1/ZFP36/ZFP36L2/TIA1	5
GO:0097110	scaffold protein binding	9/1005	67/18367	0.0104439121021726	0.0790753344878779	VIM/P2RY1/CAV2/PDE4D/IL6ST/FYN/ITPR2/ATP2B4/CRK	9
GO:0004715	non-membrane spanning protein tyrosine kinase activity	7/1005	45/18367	0.0105598906999731	0.0792871793389644	PEAK1/YES1/JAK1/FYN/EIF2AK2/DYRK1A/PTK2	7
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	4/1005	17/18367	0.011963674287137	0.0869296010702458	PTPRB/PTPRM/PTPRG/PTPRA	4
GO:0005324	long-chain fatty acid transporter activity	4/1005	17/18367	0.011963674287137	0.0869296010702458	FABP4/FABP5/CD36/SLC2A1	4
GO:0019198	transmembrane receptor protein phosphatase activity	4/1005	17/18367	0.011963674287137	0.0869296010702458	PTPRB/PTPRM/PTPRG/PTPRA	4
GO:0070064	proline-rich region binding	4/1005	17/18367	0.011963674287137	0.0869296010702458	ABI2/CYLD/CCND1/NEDD4	4
GO:0016922	nuclear receptor binding	15/1005	144/18367	0.0124467275551975	0.0885687271267661	FOXP1/ACTN4/PKN1/NCOA7/HIF1A/TACC1/STAT3/MED13/CTBP2/ETS2/TRIP12/STRN/JMJD1C/ARID1A/BAZ2A	15
GO:0033218	amide binding	33/1005	400/18367	0.0125013135758031	0.0885687271267661	RAMP2/FCGR2B/CALCRL/CRHBP/LEPR/RAMP3/ECE1/FZD4/ITGA2/NPR1/HSPG2/ITM2A/PCSK5/SCARB1/FKBP1A/HLA-E/HLA-A/HLA-B/ITM2B/HLA-C/CLU/MGST2/ERAP1/KPNA3/AP2B1/CD36/LNPEP/NKTR/TAPBP/PPP3R1/PICALM/PPP3CA/SEC61A1	33
GO:0042805	actinin binding	6/1005	36/18367	0.0125824606794962	0.0885687271267661	PDLIM4/MAGI1/PDLIM5/PDLIM7/PALLD/PKD2	6
GO:0043394	proteoglycan binding	6/1005	36/18367	0.0125824606794962	0.0885687271267661	ITGA2/FN1/AGRN/NID1/THBS1/SDCBP	6
GO:0035591	signaling adaptor activity	10/1005	81/18367	0.0127253205115475	0.0888799517899555	SH2B3/SHC1/GNB1/GNB4/ABI2/STAT3/IQGAP1/SPAG9/CRK/SAV1	10
GO:0035254	glutamate receptor binding	7/1005	47/18367	0.0133213254337739	0.092327032429464	SLC9A3R2/HIP1/CANX/CALM1/FYN/PTEN/MYL12A	7
GO:0004860	protein kinase inhibitor activity	9/1005	70/18367	0.0137455854530228	0.0945402480394928	HYAL2/SH3BP5/PKIG/SOCS3/PRKAR1A/TRIB2/WNK1/PRKAR2A/YWHAB	9
GO:0015035	protein-disulfide reductase activity	6/1005	37/18367	0.0143409206239398	0.0978876475921954	NXN/STAB1/DNAJC10/QSOX1/ERO1A/TMX3	6
GO:0017002	activin-activated receptor activity	3/1005	10/18367	0.0146697147710054	0.0982974030697475	ACVRL1/BMPR2/TGFBR2	3
GO:0030228	lipoprotein particle receptor activity	4/1005	18/18367	0.0147282457429699	0.0982974030697475	LRP6/SCARB1/STAB1/CD36	4
GO:0098641	cadherin binding involved in cell-cell adhesion	4/1005	18/18367	0.0147282457429699	0.0982974030697475	STXBP6/PDLIM5/TMOD3/CNN3	4
GO:0005543	phospholipid binding	37/1005	466/18367	0.015023886304098	0.099533246764649	SPTBN1/STXBP6/JAG1/RASA4/HIP1/SCARB1/ITPR1/SYT11/PLCB1/THBS1/PHLDA1/SCARB2/OSBPL10/AIDA/SHC1/SESTD1/PIK3C2B/ITPR2/MYO10/DYSF/SBF2/OGT/FERMT2/PIK3C2A/SDCBP/ABCA1/WDFY1/RAPGEF2/CCDC88A/IQGAP1/PICALM/GSN/WDFY3/MYOF/CPNE8/VPS36/MTSS1	37
GO:0043539	protein serine/threonine kinase activator activity	7/1005	49/18367	0.0165653507733136	0.108176840816209	BMPR2/IGF2/CCNY/CALM1/TAOK1/IQGAP1/CCNT1	7
GO:0003785	actin monomer binding	5/1005	28/18367	0.0166887690049423	0.108176840816209	PRKCE/TMSB4X/TMSB10/COBLL1/MTSS1	5
GO:0008187	poly-pyrimidine tract binding	5/1005	28/18367	0.0166887690049423	0.108176840816209	RBMS3/PABPC1/RBMS1/RBMS2/HNRNPH1	5
GO:0052742	phosphatidylinositol kinase activity	4/1005	19/18367	0.0178647514238761	0.114972435949374	PIK3R3/PIK3CA/PIK3C2B/PIK3C2A	4
GO:0004722	protein serine/threonine phosphatase activity	11/1005	98/18367	0.018059960898627	0.115006940456964	PPM1F/DUSP1/DUSP6/PTEN/MTMR6/CTDSP2/PPP3R1/PPP2CB/PPP3CA/CTDSP1/CTDSPL2	11
GO:0004714	transmembrane receptor protein tyrosine kinase activity	13/1005	124/18367	0.0182236350911154	0.115006940456964	KDR/TIE1/TEK/FGFR1/NRP1/CRIM1/YES1/JAK1/FYN/EIF2AK2/EFEMP1/DYRK1A/PTK2	13
GO:0015485	cholesterol binding	7/1005	50/18367	0.0183806874870176	0.115006940456964	CAV1/CD81/SCARB2/OSBPL10/ABCA1/STARD4/STARD3NL	7
GO:0030159	signaling receptor complex adaptor activity	7/1005	50/18367	0.0183806874870176	0.115006940456964	SH2B3/SHC1/GNB1/GNB4/SPAG9/CRK/SAV1	7
GO:0070717	poly-purine tract binding	5/1005	29/18367	0.0192812160494162	0.116301508001502	RBMS3/PABPC1/RBMS1/RBMS2/TIA1	5
GO:0002162	dystroglycan binding	3/1005	11/18367	0.019362071254412	0.116301508001502	AGRN/VCL/PLEC	3
GO:0008603	cAMP-dependent protein kinase regulator activity	3/1005	11/18367	0.019362071254412	0.116301508001502	PKIG/PRKAR1A/PRKAR2A	3
GO:0019855	calcium channel inhibitor activity	3/1005	11/18367	0.019362071254412	0.116301508001502	ITPR1/CALM1/SLC30A1	3
GO:0042608	T cell receptor binding	3/1005	11/18367	0.019362071254412	0.116301508001502	HLA-E/HLA-A/FYN	3
GO:0048407	platelet-derived growth factor binding	3/1005	11/18367	0.019362071254412	0.116301508001502	COL3A1/COL4A1/PDGFB	3
GO:0019003	GDP binding	9/1005	75/18367	0.0208759979267286	0.124564729350877	RHOB/RRAS/RAB27A/RHOA/RALB/RALA/NRAS/RAB5A/RAP1A	9
GO:0035014	phosphatidylinositol 3-kinase regulator activity	4/1005	20/18367	0.0213861512933677	0.126769225758712	PIK3R3/SOCS3/KLF4/SOCS4	4
GO:0046982	protein heterodimerization activity	27/1005	328/18367	0.0228256016643598	0.134417432023452	TCF4/P2RY1/FZD4/MEF2C/RALGAPA2/CAV1/HIP1/CAV2/EPAS1/AHR/ITGB1/MEF2A/PDGFB/ADRB1/JAM3/ZHX1/HIF1A/TCF12/SDCBP/ADD1/TPM4/ATF6/RALGAPB/SOS2/SOS1/BHLHE40/PAFAH1B2	27
GO:0017154	semaphorin receptor activity	3/1005	12/18367	0.0247841112688392	0.141451762534087	PLXND1/NRP1/PLXNA2	3
GO:0017166	vinculin binding	3/1005	12/18367	0.0247841112688392	0.141451762534087	UTRN/PXN/CTNNA1	3
GO:0035256	G protein-coupled glutamate receptor binding	3/1005	12/18367	0.0247841112688392	0.141451762534087	SLC9A3R2/CALM1/FYN	3
GO:0070410	co-SMAD binding	3/1005	12/18367	0.0247841112688392	0.141451762534087	SMAD6/SMAD1/SMAD2	3
GO:0035091	phosphatidylinositol binding	23/1005	271/18367	0.0248050815542572	0.141451762534087	STXBP6/HIP1/SCARB1/ITPR1/PLCB1/PHLDA1/AIDA/SESTD1/PIK3C2B/ITPR2/MYO10/SBF2/OGT/FERMT2/PIK3C2A/SDCBP/WDFY1/CCDC88A/IQGAP1/PICALM/GSN/WDFY3/VPS36	23
GO:0005200	structural constituent of cytoskeleton	11/1005	103/18367	0.0251917468902164	0.142055192275817	VIM/SPTBN1/BICD1/SORBS2/AGRN/HIP1/MSN/SPTAN1/TUBA1A/ACTR2/PLEC	11
GO:0043015	gamma-tubulin binding	5/1005	31/18367	0.0252262272631862	0.142055192275817	DIXDC1/GIT1/PDE4B/NDRG1/ARHGEF7	5
GO:0015036	disulfide oxidoreductase activity	6/1005	42/18367	0.025720374134549	0.143636317144802	NXN/STAB1/DNAJC10/QSOX1/ERO1A/TMX3	6
GO:0005525	GTP binding	30/1005	377/18367	0.0258258417063906	0.143636317144802	GBP4/EHD2/RHOJ/NPR1/GIMAP6/GIMAP7/GIMAP1/GIMAP8/RHOB/GIMAP4/IFI44L/TUBA1A/ATL3/GNAI2/GNAQ/MX1/RRAS/RAB27A/RHOA/RALB/EHD4/ARHGAP5/ARL5A/RALA/RAB11A/NRAS/CDC42/RAB5A/RAP1A/NIN	30
GO:0005539	glycosaminoglycan binding	20/1005	230/18367	0.0277185113358816	0.153217047322879	RSPO3/SELP/NDNF/CLEC3B/HYAL2/FN1/ENG/AGRN/FGFR1/THBS1/FSTL1/TGFBR2/STAB1/NRP1/SULF2/APP/MDK/GNS/HSD17B12/CD44	20
GO:0051721	protein phosphatase 2A binding	5/1005	32/18367	0.0285932861508426	0.157003280305854	FOXO1/CTTNBP2NL/PPP2R2A/ARPP19/STRN	5
GO:0016791	phosphatase activity	23/1005	275/18367	0.0287519880693295	0.157003280305854	PTPRB/NT5E/PLPP1/PPP2R5A/PPM1F/DUSP1/DUSP6/CDC25B/PLPP3/PTEN/MTMR6/PTPRM/PTPRG/CTDSP2/PPP3R1/PTP4A2/PPP2CB/PPP3CA/PTPN14/CTDSP1/PTPRA/PTPN12/CTDSPL2	23
GO:0042578	phosphoric ester hydrolase activity	29/1005	366/18367	0.0294611000925369	0.158872097440421	PTPRB/NT5E/PLCB4/ENPP2/PLPP1/PDE4D/PLCB1/PPP2R5A/PPM1F/DUSP1/DUSP6/CDC25B/GNB1/PLPP3/PTEN/PDE4B/MTMR6/PTPRM/PTPRG/CTDSP2/PPP3R1/PTP4A2/PPP2CB/PPP3CA/PTPN14/CTDSP1/PTPRA/PTPN12/CTDSPL2	29
GO:0005080	protein kinase C binding	7/1005	55/18367	0.0295707374361583	0.158872097440421	ADCY4/MARCKS/HDAC7/PDLIM5/PKN1/FLNA/CCDC88A	7
GO:0008093	cytoskeletal anchor activity	4/1005	22/18367	0.0296232101775703	0.158872097440421	BICD1/SORBS2/ABI2/SDCBP	4
GO:0003713	transcription coactivator activity	22/1005	262/18367	0.0307155801015826	0.160188334808191	HYAL2/WWTR1/ETS1/LMO2/NOTCH1/MTDH/ACTN4/DDX17/HIPK2/PKN1/NCOA7/TACC1/ZMIZ1/MED13/TRIM13/CTBP2/KAT6A/MAML2/ARL2BP/DYRK1A/ARID1A/BCL10	22
GO:0004535	poly(A)-specific ribonuclease activity	3/1005	13/18367	0.0309353720939236	0.160188334808191	CNOT6L/CNOT8/CNOT2	3
GO:0008035	high-density lipoprotein particle binding	3/1005	13/18367	0.0309353720939236	0.160188334808191	SCARB1/CD36/ABCA1	3
GO:0031994	insulin-like growth factor I binding	3/1005	13/18367	0.0309353720939236	0.160188334808191	IGFBP4/IGFBP3/ITGA6	3
GO:0034236	protein kinase A catalytic subunit binding	3/1005	13/18367	0.0309353720939236	0.160188334808191	PRKAR1A/PJA2/PRKAR2A	3
GO:0051011	microtubule minus-end binding	3/1005	13/18367	0.0309353720939236	0.160188334808191	MACF1/CAMSAP2/NIN	3
GO:0030374	nuclear receptor coactivator activity	7/1005	56/18367	0.0322595785442521	0.166090744390692	ETS1/ACTN4/PKN1/NCOA7/TACC1/ZMIZ1/MED13	7
GO:0001664	G protein-coupled receptor binding	24/1005	295/18367	0.034331779831818	0.173886239808793	EDN1/RSPO3/LRP6/S1PR1/SLC9A3R2/P2RY1/BICD1/PDE4D/ARHGEF12/GNAI2/JAK1/ADRB1/GNAQ/CALM1/FYN/FLNA/SDCBP/STAT3/RAPGEF2/PDCD6IP/RALA/HSPA1A/NEDD4/SAV1	24
GO:0017134	fibroblast growth factor binding	4/1005	23/18367	0.0343526644683297	0.173886239808793	KL/FGFR1/THBS1/S100A13	4
GO:0050750	low-density lipoprotein particle receptor binding	4/1005	23/18367	0.0343526644683297	0.173886239808793	HSPG2/CLU/HSP90B1/PICALM	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	7/1005	57/18367	0.0351069454186423	0.176711496213389	MSRB3/NXN/STAB1/DNAJC10/QSOX1/ERO1A/TMX3	7
GO:0004857	enzyme inhibitor activity	8/1005	70/18367	0.0367872378687031	0.18414056288723	FRY/TXNIP/NOTCH1/TMBIM6/PARP9/DTX3L/PPP1R12A/OAZ2	8
GO:0035259	glucocorticoid receptor binding	3/1005	14/18367	0.0378081707500465	0.188205314065149	TACC1/STAT3/ETS2	3
GO:0004896	cytokine receptor activity	10/1005	97/18367	0.0393126781084524	0.193395473793817	LEPR/FZD4/LIFR/IL1R1/OSMR/IL13RA1/IL6ST/CSF2RB/IFNAR1/CD44	10
GO:0001965	G-protein alpha-subunit binding	4/1005	24/18367	0.0394947471454632	0.193395473793817	F2R/SASH1/CCDC88A/NUCB1	4
GO:0019789	SUMO transferase activity	4/1005	24/18367	0.0394947471454632	0.193395473793817	HDAC7/PML/RANBP2/PIAS1	4
GO:0032934	sterol binding	7/1005	60/18367	0.0446287878651296	0.212599133819011	CAV1/CD81/SCARB2/OSBPL10/ABCA1/STARD4/STARD3NL	7
GO:0042605	peptide antigen binding	5/1005	36/18367	0.0448167899210929	0.212599133819011	HLA-E/HLA-A/HLA-B/HLA-C/TAPBP	5
GO:0042562	hormone binding	9/1005	86/18367	0.0452220143218232	0.212599133819011	RAMP2/CALCRL/CRHBP/LEPR/ECE1/NPR1/THRA/SHC1/NR3C1	9
GO:0005041	low-density lipoprotein particle receptor activity	3/1005	15/18367	0.0453886708170356	0.212599133819011	LRP6/STAB1/CD36	3
GO:0042813	Wnt-activated receptor activity	3/1005	15/18367	0.0453886708170356	0.212599133819011	LRP6/FZD4/FZD6	3
GO:0050998	nitric-oxide synthase binding	3/1005	15/18367	0.0453886708170356	0.212599133819011	CAV1/CALM1/ATP2B4	3
GO:0106306	protein serine phosphatase activity	8/1005	73/18367	0.0454947333233345	0.212599133819011	PPM1F/DUSP1/DUSP6/PTEN/CTDSP2/PPP2CB/PPP3CA/CTDSP1	8
GO:0106307	protein threonine phosphatase activity	8/1005	73/18367	0.0454947333233345	0.212599133819011	PPM1F/DUSP1/DUSP6/PTEN/CTDSP2/PPP2CB/PPP3CA/CTDSP1	8
GO:0042826	histone deacetylase binding	12/1005	127/18367	0.0455655638951274	0.212599133819011	MEF2C/MEF2A/BCOR/PKN1/KLF4/HIF1A/PKN2/CCND1/NIPBL/HES1/HSPA1A/YWHAB	12
GO:0015026	coreceptor activity	6/1005	48/18367	0.0457760621097538	0.212599133819011	RAMP2/LRP6/RAMP3/ENG/ITGB1/NRP1	6
GO:0019001	guanyl nucleotide binding	30/1005	398/18367	0.0475805323507451	0.218724794122558	GBP4/EHD2/RHOJ/NPR1/GIMAP6/GIMAP7/GIMAP1/GIMAP8/RHOB/GIMAP4/IFI44L/TUBA1A/ATL3/GNAI2/GNAQ/MX1/RRAS/RAB27A/RHOA/RALB/EHD4/ARHGAP5/ARL5A/RALA/RAB11A/NRAS/CDC42/RAB5A/RAP1A/NIN	30
GO:0032561	guanyl ribonucleotide binding	30/1005	398/18367	0.0475805323507451	0.218724794122558	GBP4/EHD2/RHOJ/NPR1/GIMAP6/GIMAP7/GIMAP1/GIMAP8/RHOB/GIMAP4/IFI44L/TUBA1A/ATL3/GNAI2/GNAQ/MX1/RRAS/RAB27A/RHOA/RALB/EHD4/ARHGAP5/ARL5A/RALA/RAB11A/NRAS/CDC42/RAB5A/RAP1A/NIN	30
GO:0003727	single-stranded RNA binding	9/1005	87/18367	0.0481026349842753	0.220002406704731	RBMS3/DDX60/PABPC1/RBMS1/RBMS2/HNRNPH1/CNBP/ZFR/TIA1	9
GO:0030551	cyclic nucleotide binding	5/1005	37/18367	0.0495786444987731	0.225607872188861	PDE4D/PRKAR1A/PDE4B/RAPGEF2/PRKAR2A	5
GO:0005092	GDP-dissociation inhibitor activity	3/1005	16/18367	0.0536578393102366	0.238156222751346	GDI1/CCDC88A/CHM	3
GO:0016307	phosphatidylinositol phosphate kinase activity	3/1005	16/18367	0.0536578393102366	0.238156222751346	PIK3CA/PIK3C2B/PIK3C2A	3
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	3/1005	16/18367	0.0536578393102366	0.238156222751346	PIK3R3/SOCS3/SOCS4	3
GO:0050700	CARD domain binding	3/1005	16/18367	0.0536578393102366	0.238156222751346	CARD16/CARD8/BCL10	3
GO:0070492	oligosaccharide binding	3/1005	16/18367	0.0536578393102366	0.238156222751346	SELP/LOXL2/LGALS1	3
GO:0030507	spectrin binding	4/1005	27/18367	0.0573991041114987	0.252276062460782	GNB1/MYO10/ADD1/CAMSAP2	4
GO:0043425	bHLH transcription factor binding	4/1005	27/18367	0.0573991041114987	0.252276062460782	TCF15/LMO2/TCF12/BHLHE40	4
GO:0051018	protein kinase A binding	6/1005	51/18367	0.0586518266249287	0.256530562082819	CRYBG3/AKAP11/PRKAR1A/RDX/PJA2/PRKAR2A	6
GO:0015278	calcium-release channel activity	3/1005	17/18367	0.0625923032437578	0.26935458933426	ITPR1/ITPR2/PKD2	3
GO:0034185	apolipoprotein binding	3/1005	17/18367	0.0625923032437578	0.26935458933426	SCARB1/CANX/ABCA1	3
GO:0042800	histone methyltransferase activity (H3-K4 specific)	3/1005	17/18367	0.0625923032437578	0.26935458933426	KMT2A/ASH1L/WDR82	3
GO:0004879	nuclear receptor activity	6/1005	52/18367	0.0633775504315906	0.26935458933426	THRA/AHR/STAT3/NR2F2/NR1D2/NR3C1	6
GO:0017046	peptide hormone binding	6/1005	52/18367	0.0633775504315906	0.26935458933426	RAMP2/CALCRL/CRHBP/LEPR/ECE1/NPR1	6
GO:0098531	ligand-activated transcription factor activity	6/1005	52/18367	0.0633775504315906	0.26935458933426	THRA/AHR/STAT3/NR2F2/NR1D2/NR3C1	6
GO:0001968	fibronectin binding	4/1005	28/18367	0.0641841599625914	0.270233309001378	THBS1/ITGB1/IGFBP3/HSD17B12	4
GO:0070325	lipoprotein particle receptor binding	4/1005	28/18367	0.0641841599625914	0.270233309001378	HSPG2/CLU/HSP90B1/PICALM	4
GO:0042169	SH2 domain binding	5/1005	40/18367	0.0655793862786818	0.274823381567871	DLC1/CCDC88A/ARHGAP5/CRK/PTK2	5
GO:0030020	extracellular matrix structural constituent conferring tensile strength	5/1005	41/18367	0.071482196657853	0.298173422170026	COL15A1/COL3A1/COL18A1/COL4A1/COL4A2	5
GO:0003924	GTPase activity	25/1005	337/18367	0.0760126379383128	0.31561007733834	GNG11/GBP4/RGS5/RHOJ/GIMAP7/RGS3/RHOB/TUBA1A/ATL3/GNAI2/GNAQ/GNB1/MX1/RRAS/RAB27A/RHOA/RALB/ARHGAP5/ARL5A/RALA/RAB11A/NRAS/CDC42/RAB5A/RAP1A	25
GO:0046966	thyroid hormone receptor binding	4/1005	30/18367	0.0789446564994284	0.326280438100849	TACC1/MED13/TRIP12/JMJD1C	4
GO:0035615	clathrin adaptor activity	3/1005	19/18367	0.0823464328664228	0.338786009190169	HIP1/AP1S2/AP2B1	3
GO:0018024	histone-lysine N-methyltransferase activity	5/1005	43/18367	0.0841282206697734	0.344543303743026	MECOM/KMT2A/ASH1L/WDR82/KMT5B	5
GO:0000146	microfilament motor activity	4/1005	31/18367	0.086902942312205	0.354296610965143	MYH9/MYO10/MYO1C/MYL6	4
GO:0015631	tubulin binding	27/1005	375/18367	0.0887761344538619	0.360303140283466	MTUS1/SYT11/MACF1/DIXDC1/DST/KIF5B/GIT1/GJA1/TAOK1/DPYSL2/FYN/CCDC69/PDE4B/CNN3/MX1/MAP4K4/NDRG1/KIF1B/APC/CCDC88A/CCSER2/ARHGEF7/MAP4/RAB11A/HSPH1/CAMSAP2/NIN	27
GO:0051879	Hsp90 protein binding	5/1005	44/18367	0.0908641618630641	0.367123810935519	KDR/AHR/SLC12A2/HIF1A/NR3C1	5
GO:0003756	protein disulfide isomerase activity	3/1005	20/18367	0.093104129614609	0.367348675813014	QSOX1/ERO1A/TMX3	3
GO:0016018	cyclosporin A binding	3/1005	20/18367	0.093104129614609	0.367348675813014	NKTR/PPP3R1/PPP3CA	3
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	3/1005	20/18367	0.093104129614609	0.367348675813014	QSOX1/ERO1A/TMX3	3
GO:0031418	L-ascorbic acid binding	3/1005	20/18367	0.093104129614609	0.367348675813014	PAM/PLOD2/EGLN1	3
GO:0140312	cargo adaptor activity	3/1005	20/18367	0.093104129614609	0.367348675813014	HIP1/AP1S2/AP2B1	3
GO:0019787	ubiquitin-like protein transferase activity	32/1005	458/18367	0.0933660896350502	0.367348675813014	RNF145/HDAC7/HACE1/RNF144B/BCOR/SMURF2/XIAP/PML/MIB1/SEL1L/RNF11/TTC3/RNF38/RNF19A/RANBP2/FBXO11/TNFAIP1/RC3H1/PJA2/HECTD1/KLHL9/TRIM13/CBLB/DTX3L/TRIP12/RNF170/CDC42/RNF213/PIAS1/UBE2E3/NEDD4/HERC2	32
GO:0005496	steroid binding	9/1005	100/18367	0.0966951172772529	0.37748019277573	KL/CAV1/CD81/SCARB2/OSBPL10/ABCA1/STARD4/NR3C1/STARD3NL	9
GO:0008235	metalloexopeptidase activity	7/1005	72/18367	0.0981686191744785	0.37748019277573	CPE/VASH1/ERAP1/CPD/LNPEP/ZMPSTE24/RNPEPL1	7
GO:0005031	tumor necrosis factor-activated receptor activity	2/1005	10/18367	0.100549662892536	0.37748019277573	TNFRSF14/TNFRSF1B	2
GO:0008239	dipeptidyl-peptidase activity	2/1005	10/18367	0.100549662892536	0.37748019277573	PRCP/DPP8	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/1005	10/18367	0.100549662892536	0.37748019277573	DUSP1/DUSP6	2
GO:0015924	mannosyl-oligosaccharide mannosidase activity	2/1005	10/18367	0.100549662892536	0.37748019277573	EDEM3/MAN1A1	2
GO:0035374	chondroitin sulfate binding	2/1005	10/18367	0.100549662892536	0.37748019277573	AGRN/MDK	2
GO:0046974	histone methyltransferase activity (H3-K9 specific)	2/1005	10/18367	0.100549662892536	0.37748019277573	MECOM/ASH1L	2
GO:0051880	G-quadruplex DNA binding	2/1005	10/18367	0.100549662892536	0.37748019277573	XRN1/CNBP	2
GO:0052813	phosphatidylinositol bisphosphate kinase activity	2/1005	10/18367	0.100549662892536	0.37748019277573	PIK3CA/PIK3C2A	2
GO:0070008	serine-type exopeptidase activity	2/1005	10/18367	0.100549662892536	0.37748019277573	PRCP/CPD	2
GO:0070577	lysine-acetylated histone binding	3/1005	21/18367	0.104404327049085	0.388711977980269	KMT2A/PHIP/BAZ2A	3
GO:0140033	acetylation-dependent protein binding	3/1005	21/18367	0.104404327049085	0.388711977980269	KMT2A/PHIP/BAZ2A	3
GO:0140296	general transcription initiation factor binding	5/1005	46/18367	0.105138256533737	0.389833617847311	TCF4/HHEX/THRA/AHR/BCL10	5
GO:0030246	carbohydrate binding	20/1005	271/18367	0.107541441321289	0.39665155720787	CD93/CD34/CLEC14A/SELP/ADGRL2/LOXL2/CLEC3B/ENPP2/ENG/PAM/CRYBG3/CANX/LGALS1/CLEC2B/PLOD2/EGLN1/CLEC1A/CD302/SLC2A3/GBE1	20
GO:0008276	protein methyltransferase activity	8/1005	88/18367	0.108297761457421	0.39665155720787	MECOM/KMT2A/FBXO11/PCMTD1/ASH1L/WDR82/KMT5B/PCMTD2	8
GO:0048306	calcium-dependent protein binding	8/1005	88/18367	0.108297761457421	0.39665155720787	A2M/SELP/S100A16/CALM1/ATP2B4/S100A13/PDCD6IP/SEC31A	8
GO:0008238	exopeptidase activity	9/1005	103/18367	0.110893746538328	0.40451524546977	CPE/PRCP/VASH1/ERAP1/CPD/LNPEP/DPP8/ZMPSTE24/RNPEPL1	9
GO:0061135	endopeptidase regulator activity	15/1005	194/18367	0.112079020884522	0.407106706725102	A2M/BST2/CD109/PROS1/TFPI2/TFPI/RPS6KA3/TIMP1/CRIM1/CARD16/APP/XIAP/CARD8/SERPINH1/ROCK1	15
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	5/1005	47/18367	0.112664939731285	0.407106706725102	PPM1F/DUSP1/DUSP6/PTEN/PTP4A2	5
GO:0030291	protein serine/threonine kinase inhibitor activity	4/1005	34/18367	0.112959685550805	0.407106706725102	PKIG/PRKAR1A/WNK1/PRKAR2A	4
GO:0043621	protein self-association	6/1005	61/18367	0.115556390188511	0.407827504888667	FOXP1/SLC2A1/CRK/PLEC/DYRK1A/BCL10	6
GO:0005540	hyaluronic acid binding	3/1005	22/18367	0.116211871818271	0.407827504888667	HYAL2/STAB1/CD44	3
GO:0004866	endopeptidase inhibitor activity	14/1005	180/18367	0.117504087526726	0.407827504888667	A2M/BST2/CD109/PROS1/TFPI2/TFPI/RPS6KA3/TIMP1/CRIM1/CARD16/APP/XIAP/SERPINH1/ROCK1	14
GO:0005078	MAP-kinase scaffold activity	2/1005	11/18367	0.11859134992323	0.407827504888667	IQGAP1/SPAG9	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/1005	11/18367	0.11859134992323	0.407827504888667	QSOX1/ERO1A	2
GO:0017128	phospholipid scramblase activity	2/1005	11/18367	0.11859134992323	0.407827504888667	PLSCR4/PLSCR1	2
GO:0019864	IgG binding	2/1005	11/18367	0.11859134992323	0.407827504888667	FCGR2B/FCGRT	2
GO:0022889	serine transmembrane transporter activity	2/1005	11/18367	0.11859134992323	0.407827504888667	SLC38A2/SERINC3	2
GO:0031434	mitogen-activated protein kinase kinase binding	2/1005	11/18367	0.11859134992323	0.407827504888667	MAP3K11/TRIB2	2
GO:0061665	SUMO ligase activity	2/1005	11/18367	0.11859134992323	0.407827504888667	RANBP2/PIAS1	2
GO:0070697	activin receptor binding	2/1005	11/18367	0.11859134992323	0.407827504888667	SMAD6/SAV1	2
GO:0097493	structural molecule activity conferring elasticity	2/1005	11/18367	0.11859134992323	0.407827504888667	LAMC1/AHNAK	2
GO:0002020	protease binding	11/1005	135/18367	0.121318359771969	0.415619171690282	VWF/A2M/COL3A1/FN1/IL1R1/ITGB1/TIMP1/CARD16/CFLAR/PTEN/BCL10	11
GO:0061134	peptidase regulator activity	17/1005	230/18367	0.128472839325025	0.435226196923333	A2M/BST2/CD109/PROS1/FN1/CAV1/TFPI2/TFPI/RPS6KA3/TIMP1/CRIM1/CARD16/APP/XIAP/CARD8/SERPINH1/ROCK1	17
GO:0017025	TBP-class protein binding	3/1005	23/18367	0.128490752920762	0.435226196923333	HHEX/THRA/AHR	3
GO:0019865	immunoglobulin binding	3/1005	23/18367	0.128490752920762	0.435226196923333	VWF/FCGR2B/FCGRT	3
GO:0051087	chaperone binding	9/1005	107/18367	0.131523829936916	0.443831351210341	VWF/FN1/HLA-B/FNIP2/CLU/DNAJC10/SCARB2/SLC12A2/HES1	9
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/1005	12/18367	0.137352797654109	0.454981142229235	CDK6/MAPK1	2
GO:0043422	protein kinase B binding	2/1005	12/18367	0.137352797654109	0.454981142229235	CCDC88A/BCL10	2
GO:0045295	gamma-catenin binding	2/1005	12/18367	0.137352797654109	0.454981142229235	CTNNA1/APC	2
GO:0061578	Lys63-specific deubiquitinase activity	2/1005	12/18367	0.137352797654109	0.454981142229235	ATXN3/CYLD	2
GO:0097677	STAT family protein binding	2/1005	12/18367	0.137352797654109	0.454981142229235	PARP9/DTX3L	2
GO:0005319	lipid transporter activity	12/1005	154/18367	0.138121958081022	0.455853055791212	FABP4/PLSCR4/CEACAM1/SLCO2A1/FABP5/ATP11A/OSBPL10/CD36/ABCA1/PLSCR1/SLC2A1/STARD4	12
GO:0099106	ion channel regulator activity	11/1005	139/18367	0.140131233582697	0.460796501671569	CAV1/ITPR1/CALM1/STIM2/FLNA/ARPP19/SLC30A1/FXYD5/ATP2B4/WNK1/NEDD4	11
GO:0043495	protein-membrane adaptor activity	3/1005	24/18367	0.141204468031519	0.460960962668111	SLC9A3R2/MYH9/SUN1	3
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	3/1005	24/18367	0.141204468031519	0.460960962668111	CDH5/SMAD6/SAV1	3
GO:0071949	FAD binding	4/1005	37/18367	0.142011931628441	0.461923286632581	QSOX1/ERO1A/AGPS/CYB5R3	4
GO:0030414	peptidase inhibitor activity	14/1005	187/18367	0.145803657850641	0.472550704041105	A2M/BST2/CD109/PROS1/TFPI2/TFPI/RPS6KA3/TIMP1/CRIM1/CARD16/APP/XIAP/SERPINH1/ROCK1	14
GO:0047485	protein N-terminus binding	9/1005	110/18367	0.148224986349595	0.478676389609266	VWF/ID1/PDLIM5/CALM1/EXOC5/SDCBP/TBL1XR1/NIPBL/HSPA1A	9
GO:0004842	ubiquitin-protein transferase activity	29/1005	433/18367	0.152028576688129	0.481870238414311	RNF145/HACE1/RNF144B/BCOR/SMURF2/XIAP/PML/MIB1/SEL1L/RNF11/TTC3/RNF38/RNF19A/FBXO11/TNFAIP1/RC3H1/PJA2/HECTD1/KLHL9/TRIM13/CBLB/DTX3L/TRIP12/RNF170/CDC42/RNF213/UBE2E3/NEDD4/HERC2	29
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	4/1005	38/18367	0.152292580084331	0.481870238414311	CNOT6L/CNOT8/CNOT2/XRN1	4
GO:0140303	intramembrane lipid transporter activity	4/1005	38/18367	0.152292580084331	0.481870238414311	PLSCR4/ATP11A/ABCA1/PLSCR1	4
GO:1901981	phosphatidylinositol phosphate binding	13/1005	173/18367	0.153671290405909	0.481870238414311	STXBP6/HIP1/PLCB1/PHLDA1/SESTD1/MYO10/OGT/FERMT2/SDCBP/IQGAP1/PICALM/GSN/VPS36	13
GO:0005112	Notch binding	3/1005	25/18367	0.154316343281566	0.481870238414311	NOTCH4/JAG1/NOTCH1	3
GO:0051019	mitogen-activated protein kinase binding	3/1005	25/18367	0.154316343281566	0.481870238414311	DUSP1/IQGAP1/NBR1	3
GO:0005035	death receptor activity	2/1005	13/18367	0.156701420483233	0.481870238414311	TNFRSF14/TNFRSF1B	2
GO:0008195	phosphatidate phosphatase activity	2/1005	13/18367	0.156701420483233	0.481870238414311	PLPP1/PLPP3	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/1005	13/18367	0.156701420483233	0.481870238414311	DUSP1/DUSP6	2
GO:0032036	myosin heavy chain binding	2/1005	13/18367	0.156701420483233	0.481870238414311	LIMCH1/MYL12B	2
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	2/1005	13/18367	0.156701420483233	0.481870238414311	KDM7A/JMJD1C	2
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	2/1005	13/18367	0.156701420483233	0.481870238414311	CCNY/CCNT1	2
GO:0070679	inositol 1,4,5 trisphosphate binding	2/1005	13/18367	0.156701420483233	0.481870238414311	ITPR1/ITPR2	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/1005	13/18367	0.156701420483233	0.481870238414311	HSD17B2/HSD17B12	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	4/1005	39/18367	0.162844846056069	0.499058524818088	MYO10/OGT/FERMT2/IQGAP1	4
GO:0140375	immune receptor activity	11/1005	144/18367	0.165680267335114	0.506026850403179	FCGR2B/LEPR/FZD4/LIFR/IL1R1/OSMR/IL13RA1/IL6ST/CSF2RB/IFNAR1/CD44	11
GO:0038187	pattern recognition receptor activity	3/1005	26/18367	0.16778981097248	0.507310804316121	SCARB1/CARD8/CD36	3
GO:0042974	retinoic acid receptor binding	3/1005	26/18367	0.16778981097248	0.507310804316121	ACTN4/TACC1/CTBP2	3
GO:0099604	ligand-gated calcium channel activity	3/1005	26/18367	0.16778981097248	0.507310804316121	ITPR1/ITPR2/PKD2	3
GO:0031072	heat shock protein binding	10/1005	129/18367	0.169055513437579	0.509428152532639	KDR/AHR/BCOR/DNAJC10/SLC12A2/HIF1A/ZFP36/CREB1/NR3C1/HSPA1A	10
GO:0016247	channel regulator activity	11/1005	145/18367	0.171049247509183	0.513717906685913	CAV1/ITPR1/CALM1/STIM2/FLNA/ARPP19/SLC30A1/FXYD5/ATP2B4/WNK1/NEDD4	11
GO:0003774	cytoskeletal motor activity	9/1005	114/18367	0.172041134349247	0.514698326398037	KIF5B/MYH9/MYO10/KIF1B/MYO1C/MYO9A/APPBP2/DYNC1H1/MYL6	9
GO:0004177	aminopeptidase activity	4/1005	40/18367	0.173652119364667	0.514698326398037	ERAP1/LNPEP/DPP8/RNPEPL1	4
GO:0004532	exoribonuclease activity	4/1005	40/18367	0.173652119364667	0.514698326398037	CNOT6L/CNOT8/CNOT2/XRN1	4
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/1005	14/18367	0.176516962105431	0.514698326398037	SH2B3/SHC1	2
GO:0015562	efflux transmembrane transporter activity	2/1005	14/18367	0.176516962105431	0.514698326398037	GJA1/XPR1	2
GO:0036041	long-chain fatty acid binding	2/1005	14/18367	0.176516962105431	0.514698326398037	FABP4/STX3	2
GO:0044548	S100 protein binding	2/1005	14/18367	0.176516962105431	0.514698326398037	AHNAK/IQGAP1	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/1005	14/18367	0.176516962105431	0.514698326398037	HSD17B2/HSD17B12	2
GO:0071837	HMG box domain binding	2/1005	14/18367	0.176516962105431	0.514698326398037	TCF12/JUN	2
GO:0070006	metalloaminopeptidase activity	3/1005	27/18367	0.181588649330102	0.527778622730394	ERAP1/LNPEP/RNPEPL1	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21/1005	310/18367	0.184173080751243	0.533568957417589	ELK3/ZEB1/DACH1/ZBTB20/HHEX/FOXP1/PLAGL1/IFI16/SKIL/SMAD5/SKI/TBX3/ZNF148/CREM/NR1D2/ETS2/HES1/NR3C1/PURB/JUN/BHLHE40	21
GO:0042054	histone methyltransferase activity	5/1005	56/18367	0.190746245965976	0.548663100272113	MECOM/KMT2A/ASH1L/WDR82/KMT5B	5
GO:0048029	monosaccharide binding	6/1005	71/18367	0.19195241952381	0.548663100272113	SELP/ENG/PAM/PLOD2/EGLN1/SLC2A3	6
GO:0001217	DNA-binding transcription repressor activity	21/1005	313/18367	0.195792060767935	0.548663100272113	ELK3/ZEB1/DACH1/ZBTB20/HHEX/FOXP1/PLAGL1/IFI16/SKIL/SMAD5/SKI/TBX3/ZNF148/CREM/NR1D2/ETS2/HES1/NR3C1/PURB/JUN/BHLHE40	21
GO:0001046	core promoter sequence-specific DNA binding	4/1005	42/18367	0.195963967959893	0.548663100272113	FOXP1/KLF10/NR3C1/BAZ2A	4
GO:0008307	structural constituent of muscle	4/1005	42/18367	0.195963967959893	0.548663100272113	SORBS2/TPM4/PLEC/MYL6	4
GO:0019894	kinesin binding	4/1005	42/18367	0.195963967959893	0.548663100272113	KTN1/KIF1B/SPAG9/KIFAP3	4
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/1005	15/18367	0.196690545380569	0.548663100272113	PDE4D/PDE4B	2
GO:0004559	alpha-mannosidase activity	2/1005	15/18367	0.196690545380569	0.548663100272113	EDEM3/MAN1A1	2
GO:0016846	carbon-sulfur lyase activity	2/1005	15/18367	0.196690545380569	0.548663100272113	MGST2/GLO1	2
GO:0042043	neurexin family protein binding	2/1005	15/18367	0.196690545380569	0.548663100272113	CPE/SDCBP	2
GO:0045125	bioactive lipid receptor activity	2/1005	15/18367	0.196690545380569	0.548663100272113	S1PR1/LPAR6	2
GO:1904680	peptide transmembrane transporter activity	2/1005	15/18367	0.196690545380569	0.548663100272113	GJA1/TAPBP	2
GO:0008201	heparin binding	12/1005	166/18367	0.198827463477507	0.552387999448216	RSPO3/SELP/NDNF/CLEC3B/FN1/FGFR1/THBS1/FSTL1/NRP1/APP/MDK/HSD17B12	12
GO:0005548	phospholipid transporter activity	5/1005	57/18367	0.200408869845149	0.552387999448216	PLSCR4/ATP11A/OSBPL10/ABCA1/PLSCR1	5
GO:0003678	DNA helicase activity	6/1005	72/18367	0.200478219555568	0.552387999448216	CHD9/ATRX/SETX/RECQL/G3BP1/CHD3	6
GO:0030276	clathrin binding	6/1005	72/18367	0.200478219555568	0.552387999448216	HIP1/SYT11/AP1S2/AP2B1/PIK3C2A/PICALM	6
GO:1901681	sulfur compound binding	18/1005	265/18367	0.203226528077835	0.558253359140638	CD34/RSPO3/SELP/NDNF/CLEC3B/ITGA2/FN1/AGRN/FGFR1/THBS1/FSTL1/MGST2/NRP1/APP/MDK/HSD17B12/KMT5B/SMAD4	18
GO:0004180	carboxypeptidase activity	4/1005	43/18367	0.20743430101529	0.564647447778779	CPE/PRCP/VASH1/CPD	4
GO:0005246	calcium channel regulator activity	4/1005	43/18367	0.20743430101529	0.564647447778779	ITPR1/CALM1/STIM2/SLC30A1	4
GO:0016504	peptidase activator activity	4/1005	43/18367	0.20743430101529	0.564647447778779	FN1/CAV1/APP/CARD8	4
GO:0070063	RNA polymerase binding	6/1005	73/18367	0.209139978611462	0.564861060517317	STOM/ZFP36/PKN2/WAC/NEDD4/CCNT1	6
GO:0004181	metallocarboxypeptidase activity	3/1005	29/18367	0.210020483100223	0.564861060517317	CPE/VASH1/CPD	3
GO:0033612	receptor serine/threonine kinase binding	3/1005	29/18367	0.210020483100223	0.564861060517317	CDH5/SMAD6/SAV1	3
GO:0051787	misfolded protein binding	3/1005	29/18367	0.210020483100223	0.564861060517317	CLU/DNAJC10/HSPA1A	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/1005	16/18367	0.217123789104902	0.56703922893773	PURA/CELF1	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	2/1005	16/18367	0.217123789104902	0.56703922893773	CAPN2/CAPNS1	2
GO:0005523	tropomyosin binding	2/1005	16/18367	0.217123789104902	0.56703922893773	TMOD3/CALD1	2
GO:0008191	metalloendopeptidase inhibitor activity	2/1005	16/18367	0.217123789104902	0.56703922893773	BST2/TIMP1	2
GO:0015923	mannosidase activity	2/1005	16/18367	0.217123789104902	0.56703922893773	EDEM3/MAN1A1	2
GO:0032183	SUMO binding	2/1005	16/18367	0.217123789104902	0.56703922893773	PML/HERC2	2
GO:0035173	histone kinase activity	2/1005	16/18367	0.217123789104902	0.56703922893773	PKN1/PRKAA1	2
GO:0036122	BMP binding	2/1005	16/18367	0.217123789104902	0.56703922893773	ENG/BMPR2	2
GO:0042577	lipid phosphatase activity	2/1005	16/18367	0.217123789104902	0.56703922893773	PLPP1/PLPP3	2
GO:1990404	protein ADP-ribosylase activity	2/1005	16/18367	0.217123789104902	0.56703922893773	PARP14/PARP9	2
GO:0008375	acetylglucosaminyltransferase activity	4/1005	44/18367	0.219091314930512	0.570523915469339	EOGT/MFNG/MGAT4A/OGT	4
GO:0016279	protein-lysine N-methyltransferase activity	5/1005	59/18367	0.22020891905199	0.571781660132112	MECOM/KMT2A/ASH1L/WDR82/KMT5B	5
GO:0005217	intracellular ligand-gated ion channel activity	3/1005	30/18367	0.224584463833645	0.579801151616372	ITPR1/ITPR2/PKD2	3
GO:0017147	Wnt-protein binding	3/1005	30/18367	0.224584463833645	0.579801151616372	LRP6/FZD4/FZD6	3
GO:0008017	microtubule binding	18/1005	271/18367	0.230253663359933	0.589555112658281	MTUS1/MACF1/DST/KIF5B/DPYSL2/CCDC69/CNN3/MX1/MAP4K4/NDRG1/KIF1B/APC/CCDC88A/CCSER2/MAP4/RAB11A/CAMSAP2/NIN	18
GO:0001786	phosphatidylserine binding	5/1005	60/18367	0.230325637797686	0.589555112658281	SCARB1/SYT11/THBS1/SCARB2/OSBPL10	5
GO:0016278	lysine N-methyltransferase activity	5/1005	60/18367	0.230325637797686	0.589555112658281	MECOM/KMT2A/ASH1L/WDR82/KMT5B	5
GO:0004386	helicase activity	11/1005	156/18367	0.235225344536639	0.596637650375958	DDX60L/CHD9/DDX17/DDX60/DICER1/ATRX/SETX/RECQL/G3BP1/DDX6/CHD3	11
GO:0004659	prenyltransferase activity	2/1005	17/18367	0.237727987219721	0.596637650375958	PTAR1/CHM	2
GO:0008484	sulfuric ester hydrolase activity	2/1005	17/18367	0.237727987219721	0.596637650375958	SULF2/GNS	2
GO:0008574	plus-end-directed microtubule motor activity	2/1005	17/18367	0.237727987219721	0.596637650375958	KIF5B/KIF1B	2
GO:0015095	magnesium ion transmembrane transporter activity	2/1005	17/18367	0.237727987219721	0.596637650375958	MAGT1/ZDHHC17	2
GO:0031489	myosin V binding	2/1005	17/18367	0.237727987219721	0.596637650375958	RAB27A/RAB11A	2
GO:0043395	heparan sulfate proteoglycan binding	2/1005	17/18367	0.237727987219721	0.596637650375958	ITGA2/AGRN	2
GO:0008157	protein phosphatase 1 binding	3/1005	31/18367	0.239336055425228	0.597345667418644	AKAP11/PHACTR4/SHOC2	3
GO:0140142	nucleocytoplasmic carrier activity	3/1005	31/18367	0.239336055425228	0.597345667418644	IPO11/KPNA3/XPO1	3
GO:1990841	promoter-specific chromatin binding	5/1005	62/18367	0.250940193638767	0.624577664277704	PCGF2/KLF4/EGR1/NIPBL/ATF2	5
GO:0001222	transcription corepressor binding	3/1005	32/18367	0.254243279104486	0.625883045008584	ZNF644/CTBP2/CNOT2	3
GO:0030332	cyclin binding	3/1005	32/18367	0.254243279104486	0.625883045008584	MDFIC/CDK6/TNFAIP1	3
GO:0031624	ubiquitin conjugating enzyme binding	3/1005	32/18367	0.254243279104486	0.625883045008584	RNF144B/ZMYM2/RNF19A	3
GO:0140658	ATP-dependent chromatin remodeler activity	3/1005	32/18367	0.254243279104486	0.625883045008584	CHD9/ATRX/CHD3	3
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/1005	18/18367	0.258423346279197	0.631001178855167	HSD17B2/HSD17B12	2
GO:0004438	phosphatidylinositol-3-phosphatase activity	2/1005	18/18367	0.258423346279197	0.631001178855167	PTEN/MTMR6	2
GO:0033549	MAP kinase phosphatase activity	2/1005	18/18367	0.258423346279197	0.631001178855167	DUSP1/DUSP6	2
GO:0019956	chemokine binding	3/1005	33/18367	0.269275332657877	0.652196437432116	A2M/ITGB1/ZFP36	3
GO:0031369	translation initiation factor binding	3/1005	33/18367	0.269275332657877	0.652196437432116	HHEX/SYT11/CELF1	3
GO:0051427	hormone receptor binding	3/1005	33/18367	0.269275332657877	0.652196437432116	FABP4/JAK1/FYN	3
GO:0035613	RNA stem-loop binding	2/1005	19/18367	0.279138277268936	0.672469486147891	CSDE1/RC3H1	2
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	2/1005	19/18367	0.279138277268936	0.672469486147891	PTEN/MTMR6	2
GO:0008170	N-methyltransferase activity	7/1005	97/18367	0.28064265705972	0.674290757362154	NNMT/MECOM/KMT2A/FBXO11/ASH1L/WDR82/KMT5B	7
GO:0061659	ubiquitin-like protein ligase activity	20/1005	316/18367	0.282295353860071	0.676457749542352	RNF145/HACE1/RNF144B/SMURF2/XIAP/RNF11/RNF38/RNF19A/RANBP2/RC3H1/HECTD1/TRIM13/CBLB/DTX3L/TRIP12/RNF170/CDC42/PIAS1/NEDD4/HERC2	20
GO:0043548	phosphatidylinositol 3-kinase binding	3/1005	34/18367	0.284402653345658	0.679699709985246	CALM1/FYN/GSN	3
GO:0004867	serine-type endopeptidase inhibitor activity	7/1005	98/18367	0.289326394804759	0.68963778232563	A2M/CD109/TFPI2/TFPI/CRIM1/APP/SERPINH1	7
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/1005	50/18367	0.292003533813554	0.690863613927351	CCNY/CCND1/CCNI/CCNT1	4
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	6/1005	82/18367	0.292055584201031	0.690863613927351	STXBP6/PLCB1/SESTD1/SDCBP/PICALM/GSN	6
GO:0000175	3'-5'-exoribonuclease activity	3/1005	35/18367	0.299596965215915	0.690863613927351	CNOT6L/CNOT8/CNOT2	3
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/1005	20/18367	0.299808738119417	0.690863613927351	TCF4/AHR	2
GO:0001972	retinoic acid binding	2/1005	20/18367	0.299808738119417	0.690863613927351	FABP5/NR2F2	2
GO:0004551	nucleotide diphosphatase activity	2/1005	20/18367	0.299808738119417	0.690863613927351	ENPP2/NUDT3	2
GO:0016408	C-acyltransferase activity	2/1005	20/18367	0.299808738119417	0.690863613927351	SPTLC2/ACAT1	2
GO:0030506	ankyrin binding	2/1005	20/18367	0.299808738119417	0.690863613927351	SPTBN1/PLEC	2
GO:0031681	G-protein beta-subunit binding	2/1005	20/18367	0.299808738119417	0.690863613927351	GNG11/F2R	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/1005	20/18367	0.299808738119417	0.690863613927351	GNAI2/GNAQ	2
GO:0042288	MHC class I protein binding	2/1005	20/18367	0.299808738119417	0.690863613927351	HLA-E/TAPBP	2
GO:0061608	nuclear import signal receptor activity	2/1005	20/18367	0.299808738119417	0.690863613927351	IPO11/KPNA3	2
GO:0070300	phosphatidic acid binding	2/1005	20/18367	0.299808738119417	0.690863613927351	SESTD1/RAPGEF2	2
GO:0016860	intramolecular oxidoreductase activity	4/1005	51/18367	0.304496755085537	0.69987647023487	MRI1/QSOX1/ERO1A/TMX3	4
GO:0015248	sterol transporter activity	3/1005	36/18367	0.314831312614577	0.719956884938411	OSBPL10/ABCA1/STARD4	3
GO:0042162	telomeric DNA binding	3/1005	36/18367	0.314831312614577	0.719956884938411	HMBOX1/PURA/SMG1	3
GO:0001848	complement binding	2/1005	21/18367	0.320377623495241	0.72345924503562	CD93/CD59	2
GO:0005123	death receptor binding	2/1005	21/18367	0.320377623495241	0.72345924503562	CFLAR/FEM1B	2
GO:0005243	gap junction channel activity	2/1005	21/18367	0.320377623495241	0.72345924503562	GJA1/GJA5	2
GO:0008373	sialyltransferase activity	2/1005	21/18367	0.320377623495241	0.72345924503562	ST6GAL1/ST3GAL5	2
GO:0051010	microtubule plus-end binding	2/1005	21/18367	0.320377623495241	0.72345924503562	DST/APC	2
GO:0005109	frizzled binding	3/1005	37/18367	0.330080081525118	0.73980635187595	RSPO3/LRP6/SDCBP	3
GO:0016409	palmitoyltransferase activity	3/1005	37/18367	0.330080081525118	0.73980635187595	SPTLC2/CPT1A/ZDHHC17	3
GO:0043531	ADP binding	3/1005	37/18367	0.330080081525118	0.73980635187595	P2RY1/MYH9/CYB5R3	3
GO:0004602	glutathione peroxidase activity	2/1005	22/18367	0.340794198662938	0.74709385157009	CLIC2/MGST2	2
GO:0005355	glucose transmembrane transporter activity	2/1005	22/18367	0.340794198662938	0.74709385157009	SLC2A1/SLC2A3	2
GO:0008320	protein transmembrane transporter activity	2/1005	22/18367	0.340794198662938	0.74709385157009	ABCA1/SEC61A1	2
GO:0009975	cyclase activity	2/1005	22/18367	0.340794198662938	0.74709385157009	ADCY4/NPR1	2
GO:0015149	hexose transmembrane transporter activity	2/1005	22/18367	0.340794198662938	0.74709385157009	SLC2A1/SLC2A3	2
GO:0030742	GTP-dependent protein binding	2/1005	22/18367	0.340794198662938	0.74709385157009	RAPGEF5/CDC42	2
GO:0033691	sialic acid binding	2/1005	22/18367	0.340794198662938	0.74709385157009	SELP/AGRN	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/1005	22/18367	0.340794198662938	0.74709385157009	RPS6KA3/XIAP	2
GO:0120020	cholesterol transfer activity	2/1005	22/18367	0.340794198662938	0.74709385157009	ABCA1/STARD4	2
GO:0015459	potassium channel regulator activity	4/1005	54/18367	0.342249425366523	0.748462942367082	CAV1/FLNA/ARPP19/WNK1	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/1005	38/18367	0.345319010220044	0.751527604367776	FKBP1A/FKBP9/NKTR	3
GO:0044390	ubiquitin-like protein conjugating enzyme binding	3/1005	38/18367	0.345319010220044	0.751527604367776	RNF144B/ZMYM2/RNF19A	3
GO:0008237	metallopeptidase activity	12/1005	190/18367	0.346611632175588	0.752523085759531	CPE/ECE1/TLL1/ADAM15/VASH1/ERAP1/CPD/ADAM10/LNPEP/ADAMTS6/ZMPSTE24/RNPEPL1	12
GO:0042393	histone binding	15/1005	244/18367	0.358672542328097	0.765348777829563	KMT2E/PKN1/ATRX/KMT2A/ZMYND11/KDM7A/PARP9/TBL1XR1/RSF1/PHIP/KAT6A/DTX3L/BPTF/BAZ2A/PHC3	15
GO:0003697	single-stranded DNA binding	8/1005	123/18367	0.359819386592275	0.765348777829563	RBMS1/PURA/SSBP4/RECQL/PCBP2/FAM111A/PURB/CNBP	8
GO:0008081	phosphoric diester hydrolase activity	6/1005	89/18367	0.360440574498515	0.765348777829563	PLCB4/ENPP2/PDE4D/PLCB1/GNB1/PDE4B	6
GO:0004402	histone acetyltransferase activity	3/1005	39/18367	0.360525190567041	0.765348777829563	CLOCK/KAT6A/ATF2	3
GO:0005504	fatty acid binding	3/1005	39/18367	0.360525190567041	0.765348777829563	FABP4/FABP5/STX3	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/1005	23/18367	0.361013574447907	0.765348777829563	PARP14/PARP9	2
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/1005	23/18367	0.361013574447907	0.765348777829563	PDE4D/PDE4B	2
GO:0005212	structural constituent of eye lens	2/1005	23/18367	0.361013574447907	0.765348777829563	VIM/CRYBG3	2
GO:0016849	phosphorus-oxygen lyase activity	2/1005	23/18367	0.361013574447907	0.765348777829563	ADCY4/NPR1	2
GO:0120015	sterol transfer activity	2/1005	23/18367	0.361013574447907	0.765348777829563	ABCA1/STARD4	2
GO:1902936	phosphatidylinositol bisphosphate binding	7/1005	107/18367	0.369582993051155	0.777002624304352	STXBP6/HIP1/PLCB1/SESTD1/SDCBP/PICALM/GSN	7
GO:0035064	methylated histone binding	5/1005	73/18367	0.369960184047244	0.777002624304352	KMT2E/ATRX/ZMYND11/KDM7A/BPTF	5
GO:0140034	methylation-dependent protein binding	5/1005	73/18367	0.369960184047244	0.777002624304352	KMT2E/ATRX/ZMYND11/KDM7A/BPTF	5
GO:0140104	molecular carrier activity	5/1005	73/18367	0.369960184047244	0.777002624304352	CLU/IPO11/KPNA3/XPO1/ATOX1	5
GO:0017080	sodium channel regulator activity	3/1005	40/18367	0.375677061205071	0.78172062851217	FXYD5/ATP2B4/NEDD4	3
GO:0042287	MHC protein binding	3/1005	40/18367	0.375677061205071	0.78172062851217	HLA-E/CD81/TAPBP	3
GO:0043014	alpha-tubulin binding	3/1005	40/18367	0.375677061205071	0.78172062851217	TAOK1/FYN/HSPH1	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/1005	40/18367	0.375677061205071	0.78172062851217	RPS6KA3/XIAP/CARD8	3
GO:0000030	mannosyltransferase activity	2/1005	24/18367	0.38099622048576	0.784727534642005	DPY19L4/TMTC3	2
GO:0008171	O-methyltransferase activity	2/1005	24/18367	0.38099622048576	0.784727534642005	PCMTD1/PCMTD2	2
GO:0015145	monosaccharide transmembrane transporter activity	2/1005	24/18367	0.38099622048576	0.784727534642005	SLC2A1/SLC2A3	2
GO:0070840	dynein complex binding	2/1005	24/18367	0.38099622048576	0.784727534642005	BICD1/APC	2
GO:0016859	cis-trans isomerase activity	3/1005	41/18367	0.390754393688573	0.784727534642005	FKBP1A/FKBP9/NKTR	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/1005	41/18367	0.390754393688573	0.784727534642005	ACSL3/DIP2A/UBA6	3
GO:0061733	peptide-lysine-N-acetyltransferase activity	3/1005	41/18367	0.390754393688573	0.784727534642005	CLOCK/KAT6A/ATF2	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	4/1005	58/18367	0.392696241454864	0.784727534642005	MGST2/PTAR1/AGPS/CHM	4
GO:0016758	hexosyltransferase activity	12/1005	197/18367	0.393451232241912	0.784727534642005	EOGT/UGCG/MFNG/FUT11/CHSY1/MGAT4A/OGT/DPY19L4/GBE1/B4GALT5/RPN1/TMTC3	12
GO:0008083	growth factor activity	10/1005	162/18367	0.394054086296923	0.784727534642005	IGF1/VEGFC/JAG1/IGF2/TIMP1/PDGFB/MDK/TGFB1/EFEMP1/CD320	10
GO:0008047	enzyme activator activity	7/1005	110/18367	0.396766891047689	0.784727534642005	PRKCE/MGST2/PDGFB/CALM1/CFLAR/FYN/DTX3L	7
GO:0061630	ubiquitin protein ligase activity	18/1005	304/18367	0.399424668967404	0.784727534642005	RNF145/HACE1/RNF144B/SMURF2/XIAP/RNF11/RNF38/RNF19A/RC3H1/HECTD1/TRIM13/CBLB/DTX3L/TRIP12/RNF170/CDC42/NEDD4/HERC2	18
GO:0072341	modified amino acid binding	6/1005	93/18367	0.400021128822296	0.784727534642005	SCARB1/SYT11/THBS1/MGST2/SCARB2/OSBPL10	6
GO:0003887	DNA-directed DNA polymerase activity	2/1005	25/18367	0.40070751415569	0.784727534642005	REV3L/POLK	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	2/1005	25/18367	0.40070751415569	0.784727534642005	PDE4D/PDE4B	2
GO:0005104	fibroblast growth factor receptor binding	2/1005	25/18367	0.40070751415569	0.784727534642005	KL/NPTN	2
GO:0034237	protein kinase A regulatory subunit binding	2/1005	25/18367	0.40070751415569	0.784727534642005	AKAP11/PJA2	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	4/1005	59/18367	0.405240773993255	0.784727534642005	CNOT6L/CNOT8/CNOT2/XRN1	4
GO:0008094	ATP-dependent activity, acting on DNA	7/1005	111/18367	0.405832383273882	0.784727534642005	CHD9/ATRX/SETX/RECQL/G3BP1/BPTF/CHD3	7
GO:0016757	glycosyltransferase activity	16/1005	270/18367	0.407841797521922	0.784727534642005	EOGT/UGCG/ST6GAL1/MFNG/ST3GAL5/FUT11/CHSY1/PARP14/MGAT4A/OGT/PARP9/DPY19L4/GBE1/B4GALT5/RPN1/TMTC3	16
GO:0003724	RNA helicase activity	5/1005	77/18367	0.413950551838546	0.784727534642005	DDX60L/DDX17/DDX60/G3BP1/DDX6	5
GO:0004435	phosphatidylinositol phospholipase C activity	2/1005	26/18367	0.420117322754291	0.784727534642005	PLCB4/PLCB1	2
GO:0030371	translation repressor activity	2/1005	26/18367	0.420117322754291	0.784727534642005	PURA/CELF1	2
GO:0003730	mRNA 3'-UTR binding	12/1005	201/18367	0.420448458541416	0.784727534642005	RBMS3/ZFP36L1/PABPC1/RBMS1/RBMS2/ZFP36/CELF1/RC3H1/ZFP36L2/SECISBP2L/PUM2/TIA1	12
GO:0032266	phosphatidylinositol-3-phosphate binding	3/1005	43/18367	0.420611070458941	0.784727534642005	HIP1/SESTD1/VPS36	3
GO:0005507	copper ion binding	4/1005	61/18367	0.430167120731144	0.784727534642005	LOXL2/PAM/S100A13/ATOX1	4
GO:0001094	TFIID-class transcription factor complex binding	1/1005	10/18367	0.43042142466789	0.784727534642005	AHR	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/1005	10/18367	0.43042142466789	0.784727534642005	PRKAA1	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/1005	10/18367	0.43042142466789	0.784727534642005	PTPN12	1
GO:0005522	profilin binding	1/1005	10/18367	0.43042142466789	0.784727534642005	CTTN	1
GO:0005528	FK506 binding	1/1005	10/18367	0.43042142466789	0.784727534642005	FKBP1A	1
GO:0008172	S-methyltransferase activity	1/1005	10/18367	0.43042142466789	0.784727534642005	KMT2A	1
GO:0008190	eukaryotic initiation factor 4E binding	1/1005	10/18367	0.43042142466789	0.784727534642005	HHEX	1
GO:0008519	ammonium transmembrane transporter activity	1/1005	10/18367	0.43042142466789	0.784727534642005	SLC12A2	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/1005	10/18367	0.43042142466789	0.784727534642005	UBA6	1
GO:0015279	store-operated calcium channel activity	1/1005	10/18367	0.43042142466789	0.784727534642005	STIM2	1
GO:0015643	toxic substance binding	1/1005	10/18367	0.43042142466789	0.784727534642005	TMEM181	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/1005	10/18367	0.43042142466789	0.784727534642005	PDGFB	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/1005	10/18367	0.43042142466789	0.784727534642005	CYB5R3	1
GO:0019869	chloride channel inhibitor activity	1/1005	10/18367	0.43042142466789	0.784727534642005	WNK1	1
GO:0030957	Tat protein binding	1/1005	10/18367	0.43042142466789	0.784727534642005	MDFIC	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/1005	10/18367	0.43042142466789	0.784727534642005	HDAC7	1
GO:0031419	cobalamin binding	1/1005	10/18367	0.43042142466789	0.784727534642005	CD320	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/1005	10/18367	0.43042142466789	0.784727534642005	HDAC7	1
GO:0035612	AP-2 adaptor complex binding	1/1005	10/18367	0.43042142466789	0.784727534642005	HIP1	1
GO:0043208	glycosphingolipid binding	1/1005	10/18367	0.43042142466789	0.784727534642005	SELP	1
GO:0045294	alpha-catenin binding	1/1005	10/18367	0.43042142466789	0.784727534642005	VCL	1
GO:0050786	RAGE receptor binding	1/1005	10/18367	0.43042142466789	0.784727534642005	S100A13	1
GO:0051864	histone H3-methyl-lysine-36 demethylase activity	1/1005	10/18367	0.43042142466789	0.784727534642005	KDM7A	1
GO:0070016	armadillo repeat domain binding	1/1005	10/18367	0.43042142466789	0.784727534642005	STRN	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/1005	10/18367	0.43042142466789	0.784727534642005	CFLAR	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/1005	10/18367	0.43042142466789	0.784727534642005	ADRB1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	3/1005	44/18367	0.435356418424435	0.784727534642005	RPS6KA2/DYRK1A/MAPK1	3
GO:0008186	ATP-dependent activity, acting on RNA	5/1005	79/18367	0.435788877783965	0.784727534642005	DDX60L/DDX17/DDX60/G3BP1/DDX6	5
GO:0140677	molecular function activator activity	9/1005	150/18367	0.437291133805799	0.784727534642005	BMPR2/PRKCE/MGST2/PDGFB/DNAJC10/CALM1/CFLAR/FYN/DTX3L	9
GO:0004709	MAP kinase kinase kinase activity	2/1005	27/18367	0.439199616628226	0.784727534642005	MAP3K3/MAP3K11	2
GO:0016405	CoA-ligase activity	2/1005	27/18367	0.439199616628226	0.784727534642005	ACSL3/DIP2A	2
GO:0022884	macromolecule transmembrane transporter activity	2/1005	27/18367	0.439199616628226	0.784727534642005	ABCA1/SEC61A1	2
GO:0023026	MHC class II protein complex binding	2/1005	27/18367	0.439199616628226	0.784727534642005	B2M/CD81	2
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/1005	27/18367	0.439199616628226	0.784727534642005	PTEN/MTMR6	2
GO:0035255	ionotropic glutamate receptor binding	2/1005	27/18367	0.439199616628226	0.784727534642005	CANX/PTEN	2
GO:0051119	sugar transmembrane transporter activity	2/1005	27/18367	0.439199616628226	0.784727534642005	SLC2A1/SLC2A3	2
GO:0051959	dynein light intermediate chain binding	2/1005	27/18367	0.439199616628226	0.784727534642005	CCDC88A/DYNC1H1	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/1005	27/18367	0.439199616628226	0.784727534642005	ATP11A/ABCA1	2
GO:0004527	exonuclease activity	5/1005	80/18367	0.446641993100767	0.784727534642005	ENPP2/CNOT6L/CNOT8/CNOT2/XRN1	5
GO:0004629	phospholipase C activity	2/1005	28/18367	0.45793211113392	0.784727534642005	PLCB4/PLCB1	2
GO:0015101	organic cation transmembrane transporter activity	2/1005	28/18367	0.45793211113392	0.784727534642005	SLC44A2/SLC44A1	2
GO:0050681	androgen receptor binding	2/1005	28/18367	0.45793211113392	0.784727534642005	FOXP1/PKN1	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/1005	28/18367	0.45793211113392	0.784727534642005	HIP1/SESTD1	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/1005	28/18367	0.45793211113392	0.784727534642005	FEM1B/APPBP2	2
GO:0043177	organic acid binding	8/1005	135/18367	0.460510635414472	0.784727534642005	ID3/PAM/FABP5/DDAH2/STX3/PLOD2/EGLN1/NR2F2	8
GO:0000774	adenyl-nucleotide exchange factor activity	1/1005	11/18367	0.461604432142356	0.784727534642005	HSPH1	1
GO:0004016	adenylate cyclase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	ADCY4	1
GO:0004143	diacylglycerol kinase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	DGKH	1
GO:0005049	nuclear export signal receptor activity	1/1005	11/18367	0.461604432142356	0.784727534642005	XPO1	1
GO:0005247	voltage-gated chloride channel activity	1/1005	11/18367	0.461604432142356	0.784727534642005	CLCN3	1
GO:0005536	glucose binding	1/1005	11/18367	0.461604432142356	0.784727534642005	SLC2A3	1
GO:0010485	H4 histone acetyltransferase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	ATF2	1
GO:0015378	sodium:chloride symporter activity	1/1005	11/18367	0.461604432142356	0.784727534642005	SLC12A2	1
GO:0016273	arginine N-methyltransferase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	FBXO11	1
GO:0016274	protein-arginine N-methyltransferase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	FBXO11	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/1005	11/18367	0.461604432142356	0.784727534642005	DDAH2	1
GO:0019107	myristoyltransferase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	ZDHHC17	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/1005	11/18367	0.461604432142356	0.784727534642005	HSD17B2	1
GO:0031996	thioesterase binding	1/1005	11/18367	0.461604432142356	0.784727534642005	CDC42	1
GO:0035197	siRNA binding	1/1005	11/18367	0.461604432142356	0.784727534642005	DICER1	1
GO:0035251	UDP-glucosyltransferase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	UGCG	1
GO:0035673	oligopeptide transmembrane transporter activity	1/1005	11/18367	0.461604432142356	0.784727534642005	GJA1	1
GO:0043295	glutathione binding	1/1005	11/18367	0.461604432142356	0.784727534642005	MGST2	1
GO:0043560	insulin receptor substrate binding	1/1005	11/18367	0.461604432142356	0.784727534642005	PIK3CA	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/1005	11/18367	0.461604432142356	0.784727534642005	ASH1L	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/1005	11/18367	0.461604432142356	0.784727534642005	NXN	1
GO:0047676	arachidonate-CoA ligase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	ACSL3	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	MTMR6	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	1/1005	11/18367	0.461604432142356	0.784727534642005	PLA1A	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/1005	11/18367	0.461604432142356	0.784727534642005	CD200	1
GO:1990459	transferrin receptor binding	1/1005	11/18367	0.461604432142356	0.784727534642005	CD81	1
GO:0061980	regulatory RNA binding	3/1005	46/18367	0.464405381030262	0.788002350863024	DICER1/RC3H1/PUM2	3
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2/1005	29/18367	0.476295935432712	0.796183001530378	CDK6/CDK17	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/1005	29/18367	0.476295935432712	0.796183001530378	ZADH2/LBR	2
GO:0032452	histone demethylase activity	2/1005	29/18367	0.476295935432712	0.796183001530378	KDM7A/JMJD1C	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/1005	29/18367	0.476295935432712	0.796183001530378	HIP1/SESTD1	2
GO:0046625	sphingolipid binding	2/1005	29/18367	0.476295935432712	0.796183001530378	SELP/S1PR1	2
GO:0051059	NF-kappaB binding	2/1005	29/18367	0.476295935432712	0.796183001530378	MTDH/BCL10	2
GO:0097472	cyclin-dependent protein kinase activity	2/1005	29/18367	0.476295935432712	0.796183001530378	CDK6/CDK17	2
GO:0140457	protein demethylase activity	2/1005	29/18367	0.476295935432712	0.796183001530378	KDM7A/JMJD1C	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	9/1005	156/18367	0.484187252277033	0.803021324803959	NNMT/MECOM/KMT2A/FBXO11/PCMTD1/ASH1L/WDR82/KMT5B/PCMTD2	9
GO:0005095	GTPase inhibitor activity	1/1005	12/18367	0.491081853459469	0.803021324803959	IQGAP1	1
GO:0005165	neurotrophin receptor binding	1/1005	12/18367	0.491081853459469	0.803021324803959	SHC1	1
GO:0005527	macrolide binding	1/1005	12/18367	0.491081853459469	0.803021324803959	FKBP1A	1
GO:0030955	potassium ion binding	1/1005	12/18367	0.491081853459469	0.803021324803959	ACAT1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/1005	12/18367	0.491081853459469	0.803021324803959	EGLN1	1
GO:0034452	dynactin binding	1/1005	12/18367	0.491081853459469	0.803021324803959	BICD1	1
GO:0035325	Toll-like receptor binding	1/1005	12/18367	0.491081853459469	0.803021324803959	CD36	1
GO:0042975	peroxisome proliferator activated receptor binding	1/1005	12/18367	0.491081853459469	0.803021324803959	TACC1	1
GO:0046790	virion binding	1/1005	12/18367	0.491081853459469	0.803021324803959	HIPK2	1
GO:0089720	caspase binding	1/1005	12/18367	0.491081853459469	0.803021324803959	CARD16	1
GO:1900750	oligopeptide binding	1/1005	12/18367	0.491081853459469	0.803021324803959	MGST2	1
GO:0022829	wide pore channel activity	2/1005	30/18367	0.494275326261218	0.803866550471763	GJA1/GJA5	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/1005	30/18367	0.494275326261218	0.803866550471763	HSD17B2/HSD17B12	2
GO:0070566	adenylyltransferase activity	2/1005	30/18367	0.494275326261218	0.803866550471763	PAPSS2/OAS2	2
GO:0031490	chromatin DNA binding	6/1005	103/18367	0.497531408458589	0.807704142380521	THRA/NOTCH1/ACTN4/STAT3/CLOCK/JMJD1C	6
GO:0032813	tumor necrosis factor receptor superfamily binding	3/1005	49/18367	0.506682210456853	0.808946621931281	TNFSF10/CFLAR/FEM1B	3
GO:0034212	peptide N-acetyltransferase activity	3/1005	49/18367	0.506682210456853	0.808946621931281	CLOCK/KAT6A/ATF2	3
GO:0016878	acid-thiol ligase activity	2/1005	31/18367	0.511857344939561	0.808946621931281	ACSL3/DIP2A	2
GO:0031210	phosphatidylcholine binding	2/1005	31/18367	0.511857344939561	0.808946621931281	SCARB2/ABCA1	2
GO:0090482	vitamin transmembrane transporter activity	2/1005	31/18367	0.511857344939561	0.808946621931281	SLC2A1/SLC2A3	2
GO:0140318	protein transporter activity	2/1005	31/18367	0.511857344939561	0.808946621931281	ABCA1/SEC61A1	2
GO:0140030	modification-dependent protein binding	9/1005	160/18367	0.514930940680658	0.808946621931281	KMT2E/PML/ATRX/KMT2A/ZMYND11/KDM7A/PHIP/BPTF/BAZ2A	9
GO:0004000	adenosine deaminase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	ADAR	1
GO:0004312	fatty acid synthase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	ELOVL5	1
GO:0008179	adenylate cyclase binding	1/1005	13/18367	0.518946889540822	0.808946621931281	CALM1	1
GO:0008253	5'-nucleotidase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	NT5E	1
GO:0008417	fucosyltransferase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	FUT11	1
GO:0008494	translation activator activity	1/1005	13/18367	0.518946889540822	0.808946621931281	PABPC1	1
GO:0015271	outward rectifier potassium channel activity	1/1005	13/18367	0.518946889540822	0.808946621931281	PKD2	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/1005	13/18367	0.518946889540822	0.808946621931281	NXN	1
GO:0016840	carbon-nitrogen lyase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	PAM	1
GO:0031386	protein tag	1/1005	13/18367	0.518946889540822	0.808946621931281	ISG15	1
GO:0031432	titin binding	1/1005	13/18367	0.518946889540822	0.808946621931281	CALM1	1
GO:0060590	ATPase regulator activity	1/1005	13/18367	0.518946889540822	0.808946621931281	HSPH1	1
GO:0061133	endopeptidase activator activity	1/1005	13/18367	0.518946889540822	0.808946621931281	CARD8	1
GO:0070700	BMP receptor binding	1/1005	13/18367	0.518946889540822	0.808946621931281	CDH5	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/1005	13/18367	0.518946889540822	0.808946621931281	PML	1
GO:0140333	glycerophospholipid flippase activity	1/1005	13/18367	0.518946889540822	0.808946621931281	ATP11A	1
GO:0005048	signal sequence binding	3/1005	50/18367	0.520385104710681	0.808970591478671	KPNA3/AP2B1/SEC61A1	3
GO:0005253	anion channel activity	5/1005	87/18367	0.520757983415793	0.808970591478671	LRRC8C/CLIC2/TTYH3/CLIC4/CLCN3	5
GO:0016887	ATP hydrolysis activity	15/1005	272/18367	0.525567511610741	0.814730924546507	DDX60L/ATP11A/KIF5B/CHD9/DDX17/DDX60/ATRX/RECQL/KIF1B/ATP2B4/G3BP1/DDX6/HSPA1A/RNF213/CHD3	15
GO:0003777	microtubule motor activity	4/1005	69/18367	0.52627458167155	0.814730924546507	KIF5B/KIF1B/APPBP2/DYNC1H1	4
GO:0004065	arylsulfatase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	SULF2	1
GO:0004298	threonine-type endopeptidase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	PSMB8	1
GO:0004707	MAP kinase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	MAPK1	1
GO:0015373	anion:sodium symporter activity	1/1005	14/18367	0.545287653189698	0.827873514116258	SLC12A2	1
GO:0015926	glucosidase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	KL	1
GO:0017110	nucleoside-diphosphatase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	ENTPD1	1
GO:0019992	diacylglycerol binding	1/1005	14/18367	0.545287653189698	0.827873514116258	RAPGEF2	1
GO:0031005	filamin binding	1/1005	14/18367	0.545287653189698	0.827873514116258	CEACAM1	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/1005	14/18367	0.545287653189698	0.827873514116258	P2RY1	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/1005	14/18367	0.545287653189698	0.827873514116258	MTMR6	1
GO:0140666	annealing activity	1/1005	14/18367	0.545287653189698	0.827873514116258	RECQL	1
GO:0001530	lipopolysaccharide binding	2/1005	33/18367	0.545790085887966	0.827873514116258	SELP/SCARB1	2
GO:0016407	acetyltransferase activity	5/1005	91/18367	0.56115356058011	0.835430608532649	ACAT1/CLOCK/KAT6A/ATF2/PAFAH1B2	5
GO:0016229	steroid dehydrogenase activity	2/1005	34/18367	0.56212680042186	0.835430608532649	HSD17B2/HSD17B12	2
GO:0035198	miRNA binding	2/1005	34/18367	0.56212680042186	0.835430608532649	RC3H1/PUM2	2
GO:0045505	dynein intermediate chain binding	2/1005	34/18367	0.56212680042186	0.835430608532649	BICD1/DYNC1H1	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/1005	34/18367	0.56212680042186	0.835430608532649	PTEN/MTMR6	2
GO:0000149	SNARE binding	6/1005	110/18367	0.562441256987244	0.835430608532649	SYT11/STX3/ABCA1/SNAP23/PICALM/RAB11A	6
GO:0001846	opsonin binding	1/1005	15/18367	0.570187446604636	0.835430608532649	CD93	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/1005	15/18367	0.570187446604636	0.835430608532649	ACSL3	1
GO:0008252	nucleotidase activity	1/1005	15/18367	0.570187446604636	0.835430608532649	NT5E	1
GO:0010851	cyclase regulator activity	1/1005	15/18367	0.570187446604636	0.835430608532649	CALM1	1
GO:0015929	hexosaminidase activity	1/1005	15/18367	0.570187446604636	0.835430608532649	HYAL2	1
GO:0017136	NAD-dependent histone deacetylase activity	1/1005	15/18367	0.570187446604636	0.835430608532649	HDAC7	1
GO:0019215	intermediate filament binding	1/1005	15/18367	0.570187446604636	0.835430608532649	VIM	1
GO:0042809	vitamin D receptor binding	1/1005	15/18367	0.570187446604636	0.835430608532649	MED13	1
GO:0043138	3'-5' DNA helicase activity	1/1005	15/18367	0.570187446604636	0.835430608532649	RECQL	1
GO:0070742	C2H2 zinc finger domain binding	1/1005	15/18367	0.570187446604636	0.835430608532649	GATA2	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/1005	15/18367	0.570187446604636	0.835430608532649	CFLAR	1
GO:1990825	sequence-specific mRNA binding	1/1005	15/18367	0.570187446604636	0.835430608532649	NOVA2	1
GO:0051213	dioxygenase activity	5/1005	92/18367	0.570982808340759	0.835430608532649	IDO1/PLOD2/KDM7A/EGLN1/JMJD1C	5
GO:0033293	monocarboxylic acid binding	4/1005	73/18367	0.571296864237084	0.835430608532649	FABP4/FABP5/STX3/NR2F2	4
GO:0004222	metalloendopeptidase activity	6/1005	111/18367	0.57139033548515	0.835430608532649	ECE1/TLL1/ADAM15/ADAM10/ADAMTS6/ZMPSTE24	6
GO:0005544	calcium-dependent phospholipid binding	3/1005	54/18367	0.573025656019065	0.835430608532649	SYT11/DYSF/CPNE8	3
GO:0008408	3'-5' exonuclease activity	3/1005	54/18367	0.573025656019065	0.835430608532649	CNOT6L/CNOT8/CNOT2	3
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/1005	54/18367	0.573025656019065	0.835430608532649	PLOD2/KDM7A/EGLN1	3
GO:0042887	amide transmembrane transporter activity	2/1005	35/18367	0.57803769952525	0.837161574988933	GJA1/TAPBP	2
GO:0005254	chloride channel activity	4/1005	74/18367	0.582172296339797	0.837161574988933	CLIC2/TTYH3/CLIC4/CLCN3	4
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	5/1005	94/18367	0.590291393551853	0.837161574988933	KL/HYAL2/EDEM3/MAN1A1/GBE1	5
GO:0000217	DNA secondary structure binding	2/1005	36/18367	0.593520428167055	0.837161574988933	MEF2C/KMT2A	2
GO:0005484	SNAP receptor activity	2/1005	36/18367	0.593520428167055	0.837161574988933	STX3/SNAP23	2
GO:0023023	MHC protein complex binding	2/1005	36/18367	0.593520428167055	0.837161574988933	B2M/CD81	2
GO:0034061	DNA polymerase activity	2/1005	36/18367	0.593520428167055	0.837161574988933	REV3L/POLK	2
GO:0005283	amino acid:sodium symporter activity	1/1005	16/18367	0.593725023771285	0.837161574988933	SLC38A2	1
GO:0008970	phospholipase A1 activity	1/1005	16/18367	0.593725023771285	0.837161574988933	PLA1A	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/1005	16/18367	0.593725023771285	0.837161574988933	SLCO2A1	1
GO:0016004	phospholipase activator activity	1/1005	16/18367	0.593725023771285	0.837161574988933	FYN	1
GO:0016208	AMP binding	1/1005	16/18367	0.593725023771285	0.837161574988933	CYB5R3	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/1005	16/18367	0.593725023771285	0.837161574988933	LOXL2	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1005	16/18367	0.593725023771285	0.837161574988933	DICER1	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/1005	16/18367	0.593725023771285	0.837161574988933	RNASE1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/1005	16/18367	0.593725023771285	0.837161574988933	HDAC7	1
GO:0050135	NAD(P)+ nucleosidase activity	1/1005	16/18367	0.593725023771285	0.837161574988933	IL1R1	1
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	1/1005	16/18367	0.593725023771285	0.837161574988933	IL1R1	1
GO:0070402	NADPH binding	1/1005	16/18367	0.593725023771285	0.837161574988933	LBR	1
GO:0140327	flippase activity	1/1005	16/18367	0.593725023771285	0.837161574988933	ATP11A	1
GO:1990380	Lys48-specific deubiquitinase activity	1/1005	16/18367	0.593725023771285	0.837161574988933	ATXN3	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/1005	56/18367	0.597957004772045	0.841811345780645	RPS6KA3/CARD16/XIAP	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/1005	37/18367	0.608574162260879	0.842175006887311	HSD17B12/FAR1	2
GO:0042056	chemoattractant activity	2/1005	37/18367	0.608574162260879	0.842175006887311	VEGFC/PDGFB	2
GO:0004540	ribonuclease activity	6/1005	116/18367	0.614722090188546	0.842175006887311	RNASE1/DICER1/CNOT6L/CNOT8/CNOT2/XRN1	6
GO:0003951	NAD+ kinase activity	1/1005	17/18367	0.615974838555758	0.842175006887311	DGKH	1
GO:0005149	interleukin-1 receptor binding	1/1005	17/18367	0.615974838555758	0.842175006887311	ERAP1	1
GO:0008308	voltage-gated anion channel activity	1/1005	17/18367	0.615974838555758	0.842175006887311	CLCN3	1
GO:0008381	mechanosensitive ion channel activity	1/1005	17/18367	0.615974838555758	0.842175006887311	PIEZO1	1
GO:0008525	phosphatidylcholine transporter activity	1/1005	17/18367	0.615974838555758	0.842175006887311	ABCA1	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	1/1005	17/18367	0.615974838555758	0.842175006887311	CARD8	1
GO:0015377	cation:chloride symporter activity	1/1005	17/18367	0.615974838555758	0.842175006887311	SLC12A2	1
GO:0017081	chloride channel regulator activity	1/1005	17/18367	0.615974838555758	0.842175006887311	WNK1	1
GO:0031420	alkali metal ion binding	1/1005	17/18367	0.615974838555758	0.842175006887311	ACAT1	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	1/1005	17/18367	0.615974838555758	0.842175006887311	ATP6V1A	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1/1005	17/18367	0.615974838555758	0.842175006887311	ATP6V1A	1
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	1/1005	17/18367	0.615974838555758	0.842175006887311	ATP6V1A	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1/1005	17/18367	0.615974838555758	0.842175006887311	ATP6V1A	1
GO:0046965	retinoid X receptor binding	1/1005	17/18367	0.615974838555758	0.842175006887311	TACC1	1
GO:0052745	inositol phosphate phosphatase activity	1/1005	17/18367	0.615974838555758	0.842175006887311	PTEN	1
GO:0070628	proteasome binding	1/1005	17/18367	0.615974838555758	0.842175006887311	ID1	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/1005	58/18367	0.6219156488854	0.846912071018581	CEACAM1/CD36/SLC16A2	3
GO:0005501	retinoid binding	2/1005	38/18367	0.623199448485371	0.846912071018581	FABP5/NR2F2	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/1005	38/18367	0.623199448485371	0.846912071018581	SLC38A2/SERINC3	2
GO:0019840	isoprenoid binding	2/1005	38/18367	0.623199448485371	0.846912071018581	FABP5/NR2F2	2
GO:0031406	carboxylic acid binding	9/1005	176/18367	0.630552608881689	0.847043730643611	FABP4/SELP/AGRN/PAM/FABP5/STX3/PLOD2/EGLN1/NR2F2	9
GO:0004708	MAP kinase kinase activity	1/1005	18/18367	0.637007279277908	0.847043730643611	MAPK1	1
GO:0005229	intracellular calcium activated chloride channel activity	1/1005	18/18367	0.637007279277908	0.847043730643611	TTYH3	1
GO:0008301	DNA binding, bending	1/1005	18/18367	0.637007279277908	0.847043730643611	HHEX	1
GO:0008409	5'-3' exonuclease activity	1/1005	18/18367	0.637007279277908	0.847043730643611	XRN1	1
GO:0008569	minus-end-directed microtubule motor activity	1/1005	18/18367	0.637007279277908	0.847043730643611	DYNC1H1	1
GO:0046527	glucosyltransferase activity	1/1005	18/18367	0.637007279277908	0.847043730643611	UGCG	1
GO:0046624	sphingolipid transporter activity	1/1005	18/18367	0.637007279277908	0.847043730643611	ABCA1	1
GO:0060229	lipase activator activity	1/1005	18/18367	0.637007279277908	0.847043730643611	FYN	1
GO:0061778	intracellular chloride channel activity	1/1005	18/18367	0.637007279277908	0.847043730643611	TTYH3	1
GO:0098918	structural constituent of synapse	1/1005	18/18367	0.637007279277908	0.847043730643611	CTBP2	1
GO:0140597	protein carrier activity	1/1005	18/18367	0.637007279277908	0.847043730643611	CLU	1
GO:1904047	S-adenosyl-L-methionine binding	1/1005	18/18367	0.637007279277908	0.847043730643611	KMT5B	1
GO:0032451	demethylase activity	2/1005	39/18367	0.637398057021497	0.847043730643611	KDM7A/JMJD1C	2
GO:0050997	quaternary ammonium group binding	2/1005	39/18367	0.637398057021497	0.847043730643611	SCARB2/ABCA1	2
GO:0004197	cysteine-type endopeptidase activity	6/1005	119/18367	0.639504828656379	0.848591827127242	CFLAR/CTSO/CAPN2/SENP7/SENP6/CAPNS1	6
GO:0045182	translation regulator activity	7/1005	140/18367	0.650459158949656	0.861537055056929	EIF4G3/PABPC1/PURA/EIF2AK2/CELF1/EIF4G2/CNBP	7
GO:0015144	carbohydrate transmembrane transporter activity	2/1005	40/18367	0.651172846274993	0.861537055056929	SLC2A1/SLC2A3	2
GO:0000339	RNA cap binding	1/1005	19/18367	0.656888890500629	0.865287851375828	EIF4G3	1
GO:0004129	cytochrome-c oxidase activity	1/1005	19/18367	0.656888890500629	0.865287851375828	COX7A1	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/1005	19/18367	0.656888890500629	0.865287851375828	SESTD1	1
GO:0051082	unfolded protein binding	6/1005	122/18367	0.663313293323303	0.871527514530575	CLU/CANX/SERPINH1/HSP90B1/TAPBP/HSPA1A	6
GO:0030331	estrogen receptor binding	2/1005	41/18367	0.664527638715322	0.871527514530575	TACC1/STRN	2
GO:0048487	beta-tubulin binding	2/1005	41/18367	0.664527638715322	0.871527514530575	SYT11/TAOK1	2
GO:0008194	UDP-glycosyltransferase activity	7/1005	143/18367	0.672204161452296	0.878484858644774	EOGT/UGCG/MFNG/CHSY1/MGAT4A/OGT/B4GALT5	7
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	1/1005	20/18367	0.675682582731219	0.878484858644774	ATP6V1A	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/1005	20/18367	0.675682582731219	0.878484858644774	CARD8	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/1005	20/18367	0.675682582731219	0.878484858644774	LOXL2	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/1005	20/18367	0.675682582731219	0.878484858644774	COX7A1	1
GO:0030296	protein tyrosine kinase activator activity	1/1005	20/18367	0.675682582731219	0.878484858644774	PAK2	1
GO:0004620	phospholipase activity	5/1005	104/18367	0.679138488584007	0.881705732297105	PLCB4/PLA1A/ENPP2/PLCB1/DDHD1	5
GO:0030544	Hsp70 protein binding	2/1005	43/18367	0.689996669780701	0.884980871748455	DNAJC10/CREB1	2
GO:0050660	flavin adenine dinucleotide binding	4/1005	85/18367	0.690586487309305	0.884980871748455	QSOX1/ERO1A/AGPS/CYB5R3	4
GO:0001614	purinergic nucleotide receptor activity	1/1005	21/18367	0.693447830693018	0.884980871748455	P2RY1	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/1005	21/18367	0.693447830693018	0.884980871748455	LPGAT1	1
GO:0004407	histone deacetylase activity	1/1005	21/18367	0.693447830693018	0.884980871748455	HDAC7	1
GO:0005385	zinc ion transmembrane transporter activity	1/1005	21/18367	0.693447830693018	0.884980871748455	SLC30A1	1
GO:0015125	bile acid transmembrane transporter activity	1/1005	21/18367	0.693447830693018	0.884980871748455	CEACAM1	1
GO:0015662	P-type ion transporter activity	1/1005	21/18367	0.693447830693018	0.884980871748455	ATP2B4	1
GO:0016502	nucleotide receptor activity	1/1005	21/18367	0.693447830693018	0.884980871748455	P2RY1	1
GO:0051428	peptide hormone receptor binding	1/1005	21/18367	0.693447830693018	0.884980871748455	FYN	1
GO:0140358	P-type transmembrane transporter activity	1/1005	21/18367	0.693447830693018	0.884980871748455	ATP2B4	1
GO:1990381	ubiquitin-specific protease binding	1/1005	21/18367	0.693447830693018	0.884980871748455	PTEN	1
GO:0016209	antioxidant activity	4/1005	86/18367	0.69937553630921	0.891283392099857	NXN/CLIC2/MGST2/TP53INP1	4
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/1005	44/18367	0.702122396035761	0.892001990040216	HSD17B12/FAR1	2
GO:0005416	amino acid:cation symporter activity	1/1005	22/18367	0.710240860789688	0.892001990040216	SLC38A2	1
GO:0015296	anion:cation symporter activity	1/1005	22/18367	0.710240860789688	0.892001990040216	SLC12A2	1
GO:0015645	fatty acid ligase activity	1/1005	22/18367	0.710240860789688	0.892001990040216	ACSL3	1
GO:0016881	acid-amino acid ligase activity	1/1005	22/18367	0.710240860789688	0.892001990040216	TTL	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/1005	22/18367	0.710240860789688	0.892001990040216	HSPG2	1
GO:0033558	protein deacetylase activity	1/1005	22/18367	0.710240860789688	0.892001990040216	HDAC7	1
GO:0055106	ubiquitin-protein transferase regulator activity	1/1005	22/18367	0.710240860789688	0.892001990040216	TRIB2	1
GO:0070034	telomerase RNA binding	1/1005	22/18367	0.710240860789688	0.892001990040216	XRN1	1
GO:0072349	modified amino acid transmembrane transporter activity	1/1005	22/18367	0.710240860789688	0.892001990040216	GJA1	1
GO:0090079	translation regulator activity, nucleic acid binding	5/1005	108/18367	0.710829554771227	0.892001990040216	EIF4G3/PABPC1/PURA/CELF1/EIF4G2	5
GO:0016298	lipase activity	6/1005	129/18367	0.714895407503619	0.895856414688123	PLCB4/PLA1A/ENPP2/PLCB1/DDHD1/LIPA	6
GO:0008234	cysteine-type peptidase activity	9/1005	190/18367	0.718269458241153	0.896920526662998	CFLAR/CTSO/ATXN3/CAPN2/CYLD/SENP7/USP31/SENP6/CAPNS1	9
GO:0004518	nuclease activity	10/1005	210/18367	0.718610735810142	0.896920526662998	RNASE1/ENPP2/ENDOD1/DICER1/CNOT6L/PLSCR1/G3BP1/CNOT8/CNOT2/XRN1	10
GO:0004864	protein phosphatase inhibitor activity	2/1005	46/18367	0.725189351528578	0.896920526662998	PHACTR2/ARPP19	2
GO:0005248	voltage-gated sodium channel activity	1/1005	23/18367	0.726114828350679	0.896920526662998	PKD2	1
GO:0015299	solute:proton antiporter activity	1/1005	23/18367	0.726114828350679	0.896920526662998	CLCN3	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/1005	23/18367	0.726114828350679	0.896920526662998	IDO1	1
GO:0030215	semaphorin receptor binding	1/1005	23/18367	0.726114828350679	0.896920526662998	SEMA3F	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/1005	23/18367	0.726114828350679	0.896920526662998	LPGAT1	1
GO:0071617	lysophospholipid acyltransferase activity	1/1005	23/18367	0.726114828350679	0.896920526662998	LPGAT1	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/1005	23/18367	0.726114828350679	0.896920526662998	MGAT4A	1
GO:0008080	N-acetyltransferase activity	3/1005	68/18367	0.726694766330731	0.896920526662998	CLOCK/KAT6A/ATF2	3
GO:0015103	inorganic anion transmembrane transporter activity	7/1005	152/18367	0.732204623891458	0.902363657673173	LRRC8C/CLIC2/TTYH3/SLC12A2/CLIC4/XPR1/CLCN3	7
GO:0032182	ubiquitin-like protein binding	5/1005	111/18367	0.733109217446085	0.902363657673173	PML/NBR1/NEDD4/VPS36/HERC2	5
GO:0019829	ATPase-coupled cation transmembrane transporter activity	2/1005	47/18367	0.736145223178209	0.902363657673173	ATP6V1A/ATP2B4	2
GO:0003707	steroid hormone receptor activity	1/1005	24/18367	0.741119985214371	0.902363657673173	NR3C1	1
GO:0004622	lysophospholipase activity	1/1005	24/18367	0.741119985214371	0.902363657673173	ENPP2	1
GO:0015252	proton channel activity	1/1005	24/18367	0.741119985214371	0.902363657673173	ATP6V1A	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/1005	24/18367	0.741119985214371	0.902363657673173	IDO1	1
GO:0019957	C-C chemokine binding	1/1005	24/18367	0.741119985214371	0.902363657673173	ZFP36	1
GO:0043274	phospholipase binding	1/1005	24/18367	0.741119985214371	0.902363657673173	FYN	1
GO:0070003	threonine-type peptidase activity	1/1005	24/18367	0.741119985214371	0.902363657673173	PSMB8	1
GO:0001098	basal transcription machinery binding	3/1005	70/18367	0.744672967363541	0.9042457460843	TCF4/AHR/WAC	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/1005	70/18367	0.744672967363541	0.9042457460843	TCF4/AHR/WAC	3
GO:0048020	CCR chemokine receptor binding	2/1005	48/18367	0.746726404329436	0.904301734275298	JAK1/STAT3	2
GO:0120013	lipid transfer activity	2/1005	48/18367	0.746726404329436	0.904301734275298	ABCA1/STARD4	2
GO:0015085	calcium ion transmembrane transporter activity	6/1005	135/18367	0.754564614815985	0.910552585901686	ITPR1/STIM2/ITPR2/PKD2/ATP2B4/SEC61A1	6
GO:0008327	methyl-CpG binding	1/1005	25/18367	0.755303838175149	0.910552585901686	ZBTB38	1
GO:0030247	polysaccharide binding	1/1005	25/18367	0.755303838175149	0.910552585901686	ENPP2	1
GO:0016763	pentosyltransferase activity	2/1005	49/18367	0.756941050877206	0.910552585901686	PARP14/PARP9	2
GO:0019212	phosphatase inhibitor activity	2/1005	49/18367	0.756941050877206	0.910552585901686	PHACTR2/ARPP19	2
GO:0140359	ABC-type transporter activity	2/1005	50/18367	0.766797548634145	0.91493907557672	ABCA1/TAPBP	2
GO:0016853	isomerase activity	7/1005	158/18367	0.767728727850459	0.91493907557672	FKBP1A/FKBP9/MRI1/QSOX1/ERO1A/NKTR/TMX3	7
GO:0004364	glutathione transferase activity	1/1005	26/18367	0.768711298791983	0.91493907557672	MGST2	1
GO:0004806	triglyceride lipase activity	1/1005	26/18367	0.768711298791983	0.91493907557672	PLA1A	1
GO:0008198	ferrous iron binding	1/1005	26/18367	0.768711298791983	0.91493907557672	EGLN1	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/1005	26/18367	0.768711298791983	0.91493907557672	ZDHHC17	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/1005	26/18367	0.768711298791983	0.91493907557672	ZDHHC17	1
GO:0097602	cullin family protein binding	1/1005	26/18367	0.768711298791983	0.91493907557672	KLHL9	1
GO:0000287	magnesium ion binding	10/1005	221/18367	0.774615216263042	0.920297682811994	RPS6KA2/CDC42BPA/SNRK/ATP11A/RPS6KA3/NUDT3/PLSCR1/WNK1/CDC42BPB/MAST4	10
GO:0003743	translation initiation factor activity	2/1005	51/18367	0.776304463820752	0.920297682811994	EIF4G3/EIF4G2	2
GO:0004601	peroxidase activity	2/1005	51/18367	0.776304463820752	0.920297682811994	CLIC2/MGST2	2
GO:0019905	syntaxin binding	3/1005	74/18367	0.777785154034095	0.920297682811994	ABCA1/SNAP23/RAB11A	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	10/1005	222/18367	0.779287743927878	0.920297682811994	SPTLC2/CPT1A/LPGAT1/ELOVL5/ACAT1/CLOCK/ZDHHC17/KAT6A/ATF2/PAFAH1B2	10
GO:0001671	ATPase activator activity	1/1005	27/18367	0.781384825029051	0.920297682811994	DNAJC10	1
GO:0008139	nuclear localization sequence binding	1/1005	27/18367	0.781384825029051	0.920297682811994	KPNA3	1
GO:0045499	chemorepellent activity	1/1005	27/18367	0.781384825029051	0.920297682811994	SEMA3F	1
GO:0005262	calcium channel activity	5/1005	119/18367	0.78633629083654	0.924920362981361	ITPR1/STIM2/ITPR2/PKD2/SEC61A1	5
GO:0003953	NAD+ nucleosidase activity	1/1005	28/18367	0.793364555173315	0.930757114858277	IL1R1	1
GO:0051861	glycolipid binding	1/1005	28/18367	0.793364555173315	0.930757114858277	SELP	1
GO:0008374	O-acyltransferase activity	2/1005	54/18367	0.802815171826994	0.94036871522599	CPT1A/LPGAT1	2
GO:0035250	UDP-galactosyltransferase activity	1/1005	29/18367	0.804688434449765	0.94036871522599	B4GALT5	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/1005	29/18367	0.804688434449765	0.94036871522599	SESTD1	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	6/1005	144/18367	0.806256947582252	0.940981230274105	KL/HYAL2/IL1R1/EDEM3/MAN1A1/GBE1	6
GO:0140097	catalytic activity, acting on DNA	10/1005	229/18367	0.81005745877284	0.944084502838754	REV3L/CHD9/DICER1/ATRX/SETX/POLK/RECQL/G3BP1/BPTF/CHD3	10
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	2/1005	55/18367	0.811011548498552	0.944084502838754	CLIC2/MGST2	2
GO:0005343	organic acid:sodium symporter activity	1/1005	30/18367	0.815392334732129	0.946737749476351	SLC38A2	1
GO:0016417	S-acyltransferase activity	1/1005	30/18367	0.815392334732129	0.946737749476351	ZDHHC17	1
GO:0051287	NAD binding	2/1005	56/18367	0.81890245752546	0.948787617544423	CTBP2/CYB5R3	2
GO:0008509	anion transmembrane transporter activity	14/1005	314/18367	0.8204623699085	0.948787617544423	LRRC8C/SLCO2A1/CLIC2/SLC38A2/SERINC3/TTYH3/SLC12A2/GJA1/CD36/CLIC4/SLC2A1/SLC2A3/XPR1/CLCN3	14
GO:0019783	ubiquitin-like protein-specific protease activity	5/1005	125/18367	0.82055811372219	0.948787617544423	ATXN3/CYLD/SENP7/USP31/SENP6	5
GO:0008528	G protein-coupled peptide receptor activity	6/1005	147/18367	0.821474316266804	0.948787617544423	APLNR/RAMP2/CALCRL/RAMP3/F2R/NPR1	6
GO:0005164	tumor necrosis factor receptor binding	1/1005	31/18367	0.825510167725214	0.948787617544423	TNFSF10	1
GO:0016411	acylglycerol O-acyltransferase activity	1/1005	31/18367	0.825510167725214	0.948787617544423	LPGAT1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/1005	31/18367	0.825510167725214	0.948787617544423	SLC2A1	1
GO:0019842	vitamin binding	6/1005	148/18367	0.826331358577355	0.948787617544423	KL/PAM/SPTLC2/PLOD2/EGLN1/CD320	6
GO:0008236	serine-type peptidase activity	8/1005	191/18367	0.826635160679658	0.948787617544423	PRSS23/CFI/PRCP/PCSK5/TLL1/CPD/HTRA1/DPP8	8
GO:0003823	antigen binding	7/1005	171/18367	0.832610522159308	0.953614279808728	HLA-E/HLA-A/HLA-B/HLA-C/TGFB1/TSPAN4/TAPBP	7
GO:0008168	methyltransferase activity	9/1005	214/18367	0.834025544329431	0.953614279808728	NNMT/MECOM/KMT2A/FBXO11/PCMTD1/ASH1L/WDR82/KMT5B/PCMTD2	9
GO:0008378	galactosyltransferase activity	1/1005	32/18367	0.835073991974569	0.953614279808728	B4GALT5	1
GO:0050699	WW domain binding	1/1005	32/18367	0.835073991974569	0.953614279808728	RAPGEF2	1
GO:0017171	serine hydrolase activity	8/1005	195/18367	0.843029034076102	0.961479948990592	PRSS23/CFI/PRCP/PCSK5/TLL1/CPD/HTRA1/DPP8	8
GO:0019239	deaminase activity	1/1005	33/18367	0.844114114039775	0.961500400442272	ADAR	1
GO:0015171	amino acid transmembrane transporter activity	3/1005	84/18367	0.845287371340456	0.96162111310322	SLC38A2/SERINC3/SLC16A2	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/1005	60/18367	0.847587482251001	0.96302184301154	ZADH2/LBR	2
GO:0001653	peptide receptor activity	6/1005	153/18367	0.849053944427051	0.963114234777882	APLNR/RAMP2/CALCRL/RAMP3/F2R/NPR1	6
GO:0008376	acetylgalactosaminyltransferase activity	1/1005	34/18367	0.852659184149409	0.963114234777882	CHSY1	1
GO:0015020	glucuronosyltransferase activity	1/1005	34/18367	0.852659184149409	0.963114234777882	CHSY1	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/1005	34/18367	0.852659184149409	0.963114234777882	DICER1	1
GO:0042626	ATPase-coupled transmembrane transporter activity	4/1005	109/18367	0.853855918112791	0.963114234777882	ATP6V1A/ABCA1/TAPBP/ATP2B4	4
GO:0015179	L-amino acid transmembrane transporter activity	2/1005	61/18367	0.854082434614349	0.963114234777882	SLC38A2/SERINC3	2
GO:0015298	solute:cation antiporter activity	1/1005	35/18367	0.860736286638355	0.968783300856213	CLCN3	1
GO:0004175	endopeptidase activity	19/1005	430/18367	0.861260182004247	0.968783300856213	PRSS23/ECE1/CFI/PCSK5/ADGRG6/TLL1/ADAM15/ERAP1/CFLAR/CTSO/CAPN2/PSMB8/ADAM10/HTRA1/SENP7/ADAMTS6/SENP6/ZMPSTE24/CAPNS1	19
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/1005	36/18367	0.86837102545182	0.974349058445941	ADAR	1
GO:0061631	ubiquitin conjugating enzyme activity	1/1005	36/18367	0.86837102545182	0.974349058445941	UBE2E3	1
GO:0016741	transferase activity, transferring one-carbon groups	9/1005	225/18367	0.8729455710144	0.978263631198973	NNMT/MECOM/KMT2A/FBXO11/PCMTD1/ASH1L/WDR82/KMT5B/PCMTD2	9
GO:0046915	transition metal ion transmembrane transporter activity	1/1005	37/18367	0.875587604984902	0.9787896179794	SLC30A1	1
GO:0071855	neuropeptide receptor binding	1/1005	37/18367	0.875587604984902	0.9787896179794	EDN1	1
GO:0004520	endodeoxyribonuclease activity	1/1005	38/18367	0.882408906511917	0.982295960650394	DICER1	1
GO:0019213	deacetylase activity	1/1005	38/18367	0.882408906511917	0.982295960650394	HDAC7	1
GO:0002039	p53 binding	2/1005	66/18367	0.882917132676748	0.982295960650394	NUAK1/HIF1A	2
GO:0016746	acyltransferase activity	10/1005	250/18367	0.883085158853296	0.982295960650394	SPTLC2/CPT1A/LPGAT1/ELOVL5/ACAT1/CLOCK/ZDHHC17/KAT6A/ATF2/PAFAH1B2	10
GO:0008514	organic anion transmembrane transporter activity	7/1005	185/18367	0.885504347178468	0.982810763185783	SLCO2A1/SLC38A2/SERINC3/GJA1/CD36/SLC2A1/SLC2A3	7
GO:0043130	ubiquitin binding	3/1005	92/18367	0.88572956682226	0.982810763185783	NBR1/NEDD4/VPS36	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/1005	39/18367	0.888856560445875	0.985067356656499	UBE2E3	1
GO:0016410	N-acyltransferase activity	3/1005	94/18367	0.894240245417476	0.989387563441106	CLOCK/KAT6A/ATF2	3
GO:0044183	protein folding chaperone	1/1005	40/18367	0.894951014655385	0.989387563441106	HSPA1A	1
GO:0004521	endoribonuclease activity	2/1005	69/18367	0.897589609133381	0.991088526751441	RNASE1/DICER1	2
GO:0051539	4 iron, 4 sulfur cluster binding	1/1005	42/18367	0.906156586664431	0.997552838944323	REV3L	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/1005	71/18367	0.906399769059525	0.997552838944323	HDAC7/GLS	2
GO:0005179	hormone activity	4/1005	122/18367	0.906765566143618	0.997552838944323	EDN1/IGF1/KL/IGF2	4
GO:0042379	chemokine receptor binding	2/1005	72/18367	0.910534191499987	0.999966154600207	JAK1/STAT3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4/1005	124/18367	0.913190777779399	0.999966154600207	HSD17B2/ZADH2/HSD17B12/CTBP2	4
GO:0015370	solute:sodium symporter activity	2/1005	73/18367	0.914496988357832	0.999966154600207	SLC38A2/SLC12A2	2
GO:0022839	ion gated channel activity	1/1005	44/18367	0.916167922406008	0.999966154600207	TTYH3	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4/1005	125/18367	0.916253014607736	0.999966154600207	HDAC7/GLS/DDAH2/ADAR	4
GO:0005245	voltage-gated calcium channel activity	1/1005	45/18367	0.920766036141857	0.999966154600207	PKD2	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/1005	45/18367	0.920766036141857	0.999966154600207	DICER1	1
GO:0005272	sodium channel activity	1/1005	46/18367	0.925112184688819	0.999966154600207	PKD2	1
GO:0004519	endonuclease activity	4/1005	129/18367	0.927558074201602	0.999966154600207	RNASE1/ENDOD1/DICER1/G3BP1	4
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/1005	47/18367	0.929220162112963	0.999966154600207	ADRB1	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/1005	48/18367	0.933103008023251	0.999966154600207	TTL	1
GO:0016779	nucleotidyltransferase activity	4/1005	132/18367	0.935113668868571	0.999966154600207	PAPSS2/REV3L/OAS2/POLK	4
GO:0000993	RNA polymerase II complex binding	1/1005	50/18367	0.940241936555555	0.999966154600207	WAC	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/1005	50/18367	0.940241936555555	0.999966154600207	IL1R1	1
GO:0030546	signaling receptor activator activity	20/1005	495/18367	0.941065706134385	0.999966154600207	EDN1/IGF1/IL33/KL/VEGFC/TNFSF10/BMPR2/JAG1/IL32/PRKCE/IGF2/TIMP1/PDGFB/APP/MDK/TGFB1/CMTM3/SEMA3F/EFEMP1/CD320	20
GO:0008227	G protein-coupled amine receptor activity	1/1005	51/18367	0.943520686010251	0.999966154600207	ADRB1	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	4/1005	136/18367	0.944075512972189	0.999966154600207	HSD17B2/ZADH2/HSD17B12/CTBP2	4
GO:0016597	amino acid binding	1/1005	52/18367	0.946619709299162	0.999966154600207	DDAH2	1
GO:1901682	sulfur compound transmembrane transporter activity	1/1005	52/18367	0.946619709299162	0.999966154600207	GJA1	1
GO:0046943	carboxylic acid transmembrane transporter activity	5/1005	163/18367	0.947726144239753	0.999966154600207	CEACAM1/SLC38A2/SERINC3/CD36/SLC16A2	5
GO:0008135	translation factor activity, RNA binding	2/1005	84/18367	0.948455778171481	0.999966154600207	EIF4G3/EIF4G2	2
GO:0005342	organic acid transmembrane transporter activity	5/1005	164/18367	0.949524413892238	0.999966154600207	CEACAM1/SLC38A2/SERINC3/CD36/SLC16A2	5
GO:0017069	snRNA binding	1/1005	53/18367	0.949548848919929	0.999966154600207	CCNT1	1
GO:0050661	NADP binding	1/1005	53/18367	0.949548848919929	0.999966154600207	LBR	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/1005	53/18367	0.949548848919929	0.999966154600207	CEACAM1	1
GO:0004843	thiol-dependent deubiquitinase	3/1005	113/18367	0.950710560378756	0.999966154600207	ATXN3/CYLD/USP31	3
GO:0099094	ligand-gated cation channel activity	3/1005	113/18367	0.950710560378756	0.999966154600207	ITPR1/ITPR2/PKD2	3
GO:0016874	ligase activity	5/1005	165/18367	0.951266380801676	0.999966154600207	TTL/ACSL3/ATP6V1A/DIP2A/UBA6	5
GO:0101005	deubiquitinase activity	3/1005	114/18367	0.952711621726736	0.999966154600207	ATXN3/CYLD/USP31	3
GO:0030170	pyridoxal phosphate binding	1/1005	55/18367	0.954934184057051	0.999966154600207	SPTLC2	1
GO:0070279	vitamin B6 binding	1/1005	56/18367	0.957407488175807	0.999966154600207	SPTLC2	1
GO:0004536	deoxyribonuclease activity	1/1005	57/18367	0.959745179966715	0.999966154600207	DICER1	1
GO:0043175	RNA polymerase core enzyme binding	1/1005	57/18367	0.959745179966715	0.999966154600207	WAC	1
GO:0016829	lyase activity	6/1005	196/18367	0.960631265246382	0.999966154600207	RNASE1/ADCY4/NPR1/PAM/MGST2/GLO1	6
GO:0052689	carboxylic ester hydrolase activity	4/1005	147/18367	0.963199238590966	0.999966154600207	PLA1A/ENPP2/LIPA/PAFAH1B2	4
GO:0036002	pre-mRNA binding	1/1005	59/18367	0.964043034741586	0.999966154600207	CELF1	1
GO:0004252	serine-type endopeptidase activity	5/1005	174/18367	0.964649119128332	0.999966154600207	PRSS23/CFI/PCSK5/TLL1/HTRA1	5
GO:0098960	postsynaptic neurotransmitter receptor activity	1/1005	62/18367	0.96964568695245	0.999966154600207	ADRB1	1
GO:0008242	omega peptidase activity	3/1005	126/18367	0.971483743339941	0.999966154600207	ATXN3/CYLD/USP31	3
GO:0009055	electron transfer activity	3/1005	126/18367	0.971483743339941	0.999966154600207	IDO1/LOXL2/COX7A1	3
GO:0015399	primary active transmembrane transporter activity	5/1005	181/18367	0.972621381837825	0.999966154600207	COX7A1/ATP6V1A/ABCA1/TAPBP/ATP2B4	5
GO:0005125	cytokine activity	7/1005	235/18367	0.975582702505908	0.999966154600207	EDN1/IL33/TNFSF10/IL32/TIMP1/TGFB1/CMTM3	7
GO:0043022	ribosome binding	1/1005	66/18367	0.975783151899622	0.999966154600207	SEC61A1	1
GO:0015078	proton transmembrane transporter activity	3/1005	130/18367	0.975985331959461	0.999966154600207	COX7A1/ATP6V1A/CLCN3	3
GO:0003684	damaged DNA binding	1/1005	68/18367	0.978369928756469	0.999966154600207	POLK	1
GO:0051536	iron-sulfur cluster binding	1/1005	68/18367	0.978369928756469	0.999966154600207	REV3L	1
GO:0051540	metal cluster binding	1/1005	68/18367	0.978369928756469	0.999966154600207	REV3L	1
GO:0015294	solute:cation symporter activity	2/1005	104/18367	0.980065920786492	0.999966154600207	SLC38A2/SLC12A2	2
GO:0031491	nucleosome binding	1/1005	71/18367	0.981741793930729	0.999966154600207	ARID1A	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	1/1005	72/18367	0.982744717908626	0.999966154600207	COX7A1	1
GO:0048018	receptor ligand activity	17/1005	487/18367	0.984689668474113	0.999966154600207	EDN1/IGF1/IL33/KL/VEGFC/TNFSF10/JAG1/IL32/IGF2/TIMP1/PDGFB/MDK/TGFB1/CMTM3/SEMA3F/EFEMP1/CD320	17
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	4/1005	170/18367	0.985264786846873	0.999966154600207	PAM/PLOD2/KDM7A/EGLN1	4
GO:0015276	ligand-gated ion channel activity	3/1005	143/18367	0.98639449478308	0.999966154600207	ITPR1/ITPR2/PKD2	3
GO:0022834	ligand-gated channel activity	3/1005	143/18367	0.98639449478308	0.999966154600207	ITPR1/ITPR2/PKD2	3
GO:0015293	symporter activity	3/1005	144/18367	0.98698386356632	0.999966154600207	SLC38A2/SLC12A2/SLC16A2	3
GO:0034987	immunoglobulin receptor binding	1/1005	79/18367	0.988382006305808	0.999966154600207	FLNA	1
GO:0005506	iron ion binding	3/1005	151/18367	0.990473586451899	0.999966154600207	PLOD2/KDM7A/EGLN1	3
GO:0015081	sodium ion transmembrane transporter activity	3/1005	152/18367	0.990891705591787	0.999966154600207	SLC38A2/SLC12A2/PKD2	3
GO:0022853	active ion transmembrane transporter activity	7/1005	267/18367	0.991972565735701	0.999966154600207	COX7A1/SLCO2A1/SLC38A2/SLC12A2/ATP6V1A/ATP2B4/CLCN3	7
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/1005	88/18367	0.993015140738577	0.999966154600207	CYB5R3	1
GO:0015297	antiporter activity	1/1005	89/18367	0.993399176164899	0.999966154600207	CLCN3	1
GO:0005249	voltage-gated potassium channel activity	1/1005	90/18367	0.993762116746706	0.999966154600207	PKD2	1
GO:0140098	catalytic activity, acting on RNA	11/1005	386/18367	0.995440608679346	0.999966154600207	RNASE1/DDX60L/DDX17/DDX60/DICER1/CNOT6L/G3BP1/CNOT8/DDX6/CNOT2/XRN1	11
GO:0005244	voltage-gated ion channel activity	4/1005	201/18367	0.995997028372768	0.999966154600207	CLIC2/PKD2/CLIC4/CLCN3	4
GO:0022832	voltage-gated channel activity	4/1005	201/18367	0.995997028372768	0.999966154600207	CLIC2/PKD2/CLIC4/CLCN3	4
GO:0004497	monooxygenase activity	1/1005	102/18367	0.996836276212665	0.999966154600207	PAM	1
GO:0015291	secondary active transmembrane transporter activity	5/1005	240/18367	0.997308283177789	0.999966154600207	SLCO2A1/SLC38A2/SLC12A2/CLCN3/SLC16A2	5
GO:0015267	channel activity	14/1005	480/18367	0.997538188416911	0.999966154600207	LRRC8C/ITPR1/CLIC2/PIEZO1/TTYH3/GJA1/STIM2/ITPR2/ATP6V1A/PKD2/CLIC4/GJA5/CLCN3/SEC61A1	14
GO:0022803	passive transmembrane transporter activity	14/1005	481/18367	0.997613942571015	0.999966154600207	LRRC8C/ITPR1/CLIC2/PIEZO1/TTYH3/GJA1/STIM2/ITPR2/ATP6V1A/PKD2/CLIC4/GJA5/CLCN3/SEC61A1	14
GO:0005216	ion channel activity	12/1005	432/18367	0.997689531004098	0.999966154600207	LRRC8C/ITPR1/CLIC2/PIEZO1/TTYH3/STIM2/ITPR2/ATP6V1A/PKD2/CLIC4/CLCN3/SEC61A1	12
GO:0043021	ribonucleoprotein complex binding	2/1005	149/18367	0.997860955892141	0.999966154600207	SECISBP2L/SEC61A1	2
GO:0046906	tetrapyrrole binding	2/1005	149/18367	0.997860955892141	0.999966154600207	IDO1/CD320	2
GO:0030594	neurotransmitter receptor activity	1/1005	111/18367	0.998099189878745	0.999966154600207	ADRB1	1
GO:0015079	potassium ion transmembrane transporter activity	2/1005	155/18367	0.998422827939276	0.999966154600207	SLC12A2/PKD2	2
GO:0022836	gated channel activity	8/1005	340/18367	0.998533099064823	0.999966154600207	ITPR1/CLIC2/PIEZO1/TTYH3/ITPR2/PKD2/CLIC4/CLCN3	8
GO:0005267	potassium channel activity	1/1005	121/18367	0.998921145619717	0.999966154600207	PKD2	1
GO:0046873	metal ion transmembrane transporter activity	11/1005	430/18367	0.998967279433876	0.999966154600207	ITPR1/SLC38A2/SLC12A2/STIM2/ITPR2/SLC30A1/PKD2/MAGT1/ATP2B4/ZDHHC17/SEC61A1	11
GO:0022804	active transmembrane transporter activity	10/1005	406/18367	0.999054022586936	0.999966154600207	COX7A1/SLCO2A1/SLC38A2/SLC12A2/ATP6V1A/ABCA1/TAPBP/ATP2B4/CLCN3/SLC16A2	10
GO:0005261	cation channel activity	7/1005	335/18367	0.999401864468221	0.999966154600207	ITPR1/PIEZO1/STIM2/ITPR2/ATP6V1A/PKD2/SEC61A1	7
GO:0020037	heme binding	1/1005	139/18367	0.999611083407522	0.999966154600207	IDO1	1
GO:0022843	voltage-gated cation channel activity	1/1005	143/18367	0.999690024580859	0.999966154600207	PKD2	1
GO:0003735	structural constituent of ribosome	1/1005	182/18367	0.999966154600207	0.999966154600207	ISG15	1