ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0003735 structural constituent of ribosome 72/347 182/18367 4.22782427059274e-77 1.87292615187258e-74 RPL13/RPL10/RPS8/RPL30/RPL18A/RPS27/RPL28/RPL11/RPL19/RPL32/RPS4X/RPL39/RPS3A/RPS6/RPL41/RPS9/RPL35A/RPS15A/RPL29/RPL9/RPS27A/RPS23/RPS11/RPS18/RPL34/RPL12/RPL13A/RPL21/RPS2/RPL26/RPS29/RPL3/RPS25/RPL5/RPS15/RPL38/RPSA/RPS19/RPS10/RPL37/RPS5/RPL7A/RPLP2/RPL10A/RPL36/RPS21/RPL6/RPS13/RPS28/RPL22/RPL35/RPL27/RPL23A/RPS7/RPS20/RPL18/RPL14/RPS12/RPL15/RPS3/RPL24/RPL8/RPL37A/RPL4/RPL36A/RPLP1/UBA52/RPS26/RPL7/RPL22L1/RPL17/RPS24 72 GO:0023026 MHC class II protein complex binding 13/347 27/18367 4.93760116345756e-16 1.09367865770585e-13 MS4A1/CD74/HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DQA2/HLA-DOB/HLA-DRB1/HLA-DMA/HLA-DMB/B2M 13 GO:0019843 rRNA binding 17/347 68/18367 6.31751598986733e-15 9.32886527837076e-13 RPL11/RPL19/RPS4X/RPS9/RPL9/RPS11/RPS18/RPL12/RPL5/RPL37/RPS5/RPS13/RPL23A/RPS3/RPL8/EEF2/GTF3A 17 GO:0023023 MHC protein complex binding 13/347 36/18367 4.87997298021423e-14 5.40457007558726e-12 MS4A1/CD74/HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DQA2/HLA-DOB/HLA-DRB1/HLA-DMA/HLA-DMB/B2M 13 GO:0003823 antigen binding 22/347 171/18367 1.39138001491791e-12 1.05264765669729e-10 IGKC/IGLC2/IGLC3/IGHM/IGHD/JCHAIN/HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DRB1/CD48/CD40/HLA-B/HLA-A/HLA-C/TRBC2/HLA-E/ITGA4/HLA-F/TAPBP 22 GO:0042605 peptide antigen binding 12/347 36/18367 1.42570788717467e-12 1.05264765669729e-10 HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DRB1/HLA-B/HLA-A/HLA-C/HLA-E/HLA-F/TAPBP 12 GO:0032395 MHC class II receptor activity 7/347 10/18367 9.24672881284163e-11 5.85185837726977e-09 HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DQA2/HLA-DOB/HLA-DRB1 7 GO:0055106 ubiquitin-protein transferase regulator activity 6/347 22/18367 2.51643824090956e-06 0.000139347767590367 RPL11/RPL5/RPS15/RPL37/RPS7/RPS20 6 GO:0045296 cadherin binding 20/347 332/18367 5.61628027627737e-06 0.000276445795821208 RPL29/RPL34/FXYD5/RPS2/RPL7A/RPL6/EEF1D/RPL23A/RPL14/RPL15/CNN2/RPL24/SNX2/EEF2/EIF2S3/RPS26/EIF3E/ARGLU1/TAGLN2/TMPO 20 GO:0048027 mRNA 5'-UTR binding 6/347 27/18367 9.21768288137362e-06 0.000408343351644851 RPS3A/RPL41/RPL26/RPL5/RPS13/RPS7 6 GO:0140375 immune receptor activity 12/347 144/18367 1.90098427867517e-05 0.000765578214048271 CD74/HLA-DRA/CXCR4/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DQA2/HLA-DOB/CCR7/HLA-DRB1/IL2RG/CD44 12 GO:0008097 5S rRNA binding 4/347 10/18367 2.40335315341099e-05 0.000887237872467558 RPL11/RPL5/EEF2/GTF3A 4 GO:0003779 actin binding 22/347 440/18367 3.56546692245398e-05 0.00117726074328576 CXCR4/TMSB4X/CORO1A/RCSD1/PHACTR1/FXYD5/GMFG/LCP1/LSP1/MARCKSL1/CNN2/WAS/TMSB10/EEF2/EPB41/ARPC3/MSN/WIPF1/TPM3/EVL/ACTR2/MTSS1 22 GO:0042608 T cell receptor binding 4/347 11/18367 3.72046284559834e-05 0.00117726074328576 HLA-DRA/HLA-DRB1/HLA-A/HLA-E 4 GO:0045182 translation regulator activity 11/347 140/18367 7.23127658978572e-05 0.00204757754270623 RPL10/EEF1B2/RPS9/EEF1A1/RPL22/EEF1D/PABPC1/EEF2/EIF2S3/EIF3E/EIF4A2 11 GO:0043274 phospholipase binding 5/347 24/18367 7.39531392399543e-05 0.00204757754270623 BANK1/BTK/WAS/SYK/BLNK 5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/347 29/18367 0.000191210681540309 0.00498272540719747 NCF1/PLEK/PLEKHA2/DAPP1/FCHSD2 5 GO:0004857 enzyme inhibitor activity 7/347 70/18367 0.000349193850242689 0.00859404864763952 TXNIP/RPL11/RPL5/RPS15/RPL37/RPS7/RPS20 7 GO:0003746 translation elongation factor activity 4/347 19/18367 0.000387693229946042 0.00903937372979455 EEF1B2/EEF1A1/EEF1D/EEF2 4 GO:0042277 peptide binding 16/347 321/18367 0.000425991114343535 0.00943570318270929 CD74/HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DRB1/HLA-B/HLA-A/HLA-C/HLA-E/CRIP1/HLA-F/TAPBP/PFDN5/PPP3CA 16 GO:0031625 ubiquitin protein ligase binding 15/347 297/18367 0.000558249313357679 0.0117764021817834 CXCR4/CD40/TXNIP/RPL11/RPS27A/LAPTM5/RPL5/LYN/JAK1/TNFRSF14/JUN/CCDC50/UBA52/PRKACB/UBXN1 15 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/347 10/18367 0.000726887677449317 0.0140735711944884 CYBA/NCF1/CYBB 3 GO:0034987 immunoglobulin receptor binding 7/347 79/18367 0.000730682025898946 0.0140735711944884 IGKC/IGLC2/IGLC3/IGHM/IGHD/JCHAIN/TRBC2 7 GO:0017124 SH3 domain binding 9/347 130/18367 0.000820772338884181 0.014786475182473 CYBA/NCF1/LYN/PTPN6/SH3BGRL/SH3BP5/WAS/WIPF1/EVL 9 GO:0019865 immunoglobulin binding 4/347 23/18367 0.000834451195399155 0.014786475182473 MS4A1/JCHAIN/FCER2/CD22 4 GO:0097371 MDM2/MDM4 family protein binding 3/347 11/18367 0.000985518820821819 0.0160965805604884 RPS15/RPL37/RPS20 3 GO:0090079 translation regulator activity, nucleic acid binding 8/347 108/18367 0.00102334120386434 0.0160965805604884 EEF1B2/EEF1A1/EEF1D/PABPC1/EEF2/EIF2S3/EIF3E/EIF4A2 8 GO:0044389 ubiquitin-like protein ligase binding 15/347 316/18367 0.00104935687396975 0.0160965805604884 CXCR4/CD40/TXNIP/RPL11/RPS27A/LAPTM5/RPL5/LYN/JAK1/TNFRSF14/JUN/CCDC50/UBA52/PRKACB/UBXN1 15 GO:0008135 translation factor activity, RNA binding 7/347 84/18367 0.00105372649267306 0.0160965805604884 EEF1B2/EEF1A1/EEF1D/EEF2/EIF2S3/EIF3E/EIF4A2 7 GO:0004715 non-membrane spanning protein tyrosine kinase activity 5/347 45/18367 0.00153682962486672 0.0226938507938652 BTK/LYN/JAK1/SYK/CSK 5 GO:0019207 kinase regulator activity 12/347 233/18367 0.00165429539948947 0.0236404149023818 TCL1A/RAC2/RHOH/GMFG/CDKN2D/SH3BP5/STK4/PKIG/RPLP1/CCNI/MOB1A/DAZAP2 12 GO:0019887 protein kinase regulator activity 11/347 204/18367 0.00178111035052712 0.0240466184365997 TCL1A/RAC2/GMFG/CDKN2D/SH3BP5/STK4/PKIG/RPLP1/CCNI/MOB1A/DAZAP2 11 GO:0003785 actin monomer binding 4/347 28/18367 0.00179128308895664 0.0240466184365997 TMSB4X/CORO1A/TMSB10/MTSS1 4 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/347 15/18367 0.00256938819963522 0.0334776168364236 CYBA/NCF1/CYBB 3 GO:0019956 chemokine binding 4/347 33/18367 0.00332436724753683 0.0420769911616804 CXCR4/CCR7/ITGA4/PLP2 4 GO:0033218 amide binding 16/347 400/18367 0.00408455016744092 0.0502626590048979 CD74/HLA-DPB1/HLA-DRA/HLA-DQA1/HLA-DPA1/HLA-DQB1/HLA-DRB1/HLA-B/HLA-A/HLA-C/HLA-E/CRIP1/HLA-F/TAPBP/PFDN5/PPP3CA 16 GO:0140678 molecular function inhibitor activity 7/347 128/18367 0.0109154429865344 0.130690303865804 TXNIP/RPL11/RPL5/RPS15/RPL37/RPS7/RPS20 7 GO:0019210 kinase inhibitor activity 5/347 74/18367 0.0130161560232912 0.151740976797842 RHOH/GMFG/CDKN2D/SH3BP5/PKIG 5 GO:0005200 structural constituent of cytoskeleton 6/347 103/18367 0.0134645876465327 0.152943905831128 HLA-DRB1/TUBA1A/EPB41/ARPC3/MSN/ACTR2 6 GO:0005522 profilin binding 2/347 10/18367 0.0144883134713304 0.156544460190229 WIPF1/EVL 2 GO:0043208 glycosphingolipid binding 2/347 10/18367 0.0144883134713304 0.156544460190229 SELL/LYN 2 GO:0050681 androgen receptor binding 3/347 28/18367 0.0154395286143557 0.162850266099037 PRKCB/DDX5/FOXP1 3 GO:0019955 cytokine binding 7/347 139/18367 0.0165629940499667 0.170637357305471 CD74/CXCR4/CCR7/IL2RG/ITGA4/PLP2/TNFRSF14 7 GO:0043015 gamma-tubulin binding 3/347 31/18367 0.0203255532502232 0.204051524400942 LYN/OFD1/PDE4B 3 GO:0043422 protein kinase B binding 2/347 12/18367 0.020727581485423 0.204051524400942 APPL1/SRSF5 2 GO:0030695 GTPase regulator activity 16/347 488/18367 0.0237344973333801 0.22284489537292 RHOH/RALGPS2/TBC1D10C/RASGRP2/ARHGDIB/SMAP2/EEF1B2/ACAP1/GPSM3/TAGAP/SH3BP5/EEF1D/WAS/JUN/MYCBP2/ITSN2 16 GO:0060589 nucleoside-triphosphatase regulator activity 16/347 488/18367 0.0237344973333801 0.22284489537292 RHOH/RALGPS2/TBC1D10C/RASGRP2/ARHGDIB/SMAP2/EEF1B2/ACAP1/GPSM3/TAGAP/SH3BP5/EEF1D/WAS/JUN/MYCBP2/ITSN2 16 GO:0031386 protein tag 2/347 13/18367 0.0241942434574261 0.22284489537292 RPS27A/UBA52 2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 15/347 450/18367 0.024648758178946 0.22284489537292 MEF2C/SPIB/IKZF3/TCF4/ETS1/HHEX/REL/KLF6/IRF1/JUN/JUNB/ELF1/IRF2/JUND/PRDM2 15 GO:0001216 DNA-binding transcription activator activity 15/347 456/18367 0.0272948451273198 0.241832327828054 MEF2C/SPIB/IKZF3/TCF4/ETS1/HHEX/REL/KLF6/IRF1/JUN/JUNB/ELF1/IRF2/JUND/PRDM2 15 GO:0004298 threonine-type endopeptidase activity 2/347 14/18367 0.0278792008731549 0.242166391898188 PSMB9/PSMB8 2 GO:0004896 cytokine receptor activity 5/347 97/18367 0.0368356392115609 0.306669557272025 CD74/CXCR4/CCR7/IL2RG/CD44 5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/347 39/18367 0.0370291003824427 0.306669557272025 BTK/DAPP1/FCHSD2 3 GO:0140297 DNA-binding transcription factor binding 13/347 394/18367 0.0374150910279443 0.306669557272025 MEF2C/PRKCB/CXXC5/HHEX/MTDH/PTMA/COMMD6/DDX5/RPS3/JUN/FOXP1/JMJD1C/JUND 13 GO:0042169 SH2 domain binding 3/347 40/18367 0.0394885371209715 0.306669557272025 PTPN6/SYK/BLNK 3 GO:0042287 MHC protein binding 3/347 40/18367 0.0394885371209715 0.306669557272025 CD74/HLA-E/TAPBP 3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/347 17/18367 0.0401508675435157 0.306669557272025 PTPRC/PTPN6 2 GO:0019198 transmembrane receptor protein phosphatase activity 2/347 17/18367 0.0401508675435157 0.306669557272025 PTPRC/PTPN6 2 GO:0030295 protein kinase activator activity 5/347 101/18367 0.0426481210101609 0.32022233233053 TCL1A/STK4/RPLP1/MOB1A/DAZAP2 5 GO:0004860 protein kinase inhibitor activity 4/347 70/18367 0.0434020744686956 0.320451983160536 GMFG/CDKN2D/SH3BP5/PKIG 4 GO:0042834 peptidoglycan binding 2/347 18/18367 0.0446173845465502 0.324024612362651 IGHM/JCHAIN 2 GO:0003725 double-stranded RNA binding 4/347 74/18367 0.0514219718590884 0.367418282799616 MTDH/MBNL1/STRBP/MSN 4 GO:0019209 kinase activator activity 5/347 107/18367 0.052347218374384 0.368092345077018 TCL1A/STK4/RPLP1/MOB1A/DAZAP2 5 GO:0042288 MHC class I protein binding 2/347 20/18367 0.0540637472992736 0.370995422130805 HLA-E/TAPBP 2 GO:0051015 actin filament binding 8/347 217/18367 0.0544349942178382 0.370995422130805 CORO1A/RCSD1/LCP1/MARCKSL1/EEF2/ARPC3/TPM3/ACTR2 8 GO:0005178 integrin binding 6/347 144/18367 0.0558927099404217 0.375158643994043 FCER2/ITGA4/LYN/LCP1/SYK/ICAM3 6 GO:0047485 protein N-terminus binding 5/347 110/18367 0.0576406903923997 0.3811168036393 RPS21/ALOX5AP/EPB41/ATM/EIF3E 5 GO:0005085 guanyl-nucleotide exchange factor activity 8/347 223/18367 0.0618379512061847 0.402856064475586 RALGPS2/RASGRP2/EEF1B2/TAGAP/SH3BP5/EEF1D/MYCBP2/ITSN2 8 GO:0003714 transcription corepressor activity 7/347 187/18367 0.065009650270927 0.412398382246534 TRIM22/BTG2/PFDN5/N4BP2L2/UXT/ATF7IP/SF1 7 GO:0043539 protein serine/threonine kinase activator activity 3/347 49/18367 0.0651645299260888 0.412398382246534 TCL1A/STK4/DAZAP2 3 GO:0016493 C-C chemokine receptor activity 2/347 23/18367 0.0693984205790224 0.42114383995215 CXCR4/CCR7 2 GO:0017134 fibroblast growth factor binding 2/347 23/18367 0.0693984205790224 0.42114383995215 RPS2/RPS19 2 GO:0070412 R-SMAD binding 2/347 23/18367 0.0693984205790224 0.42114383995215 DDX5/JUN 2 GO:0003743 translation initiation factor activity 3/347 51/18367 0.0716945640409242 0.429198538785533 EIF2S3/EIF3E/EIF4A2 3 GO:0035091 phosphatidylinositol binding 9/347 271/18367 0.0727905361602608 0.429949433586607 NCF1/BTK/SNX2/DAPP1/EPB41/FCHSD2/GGA2/AIDA/APPL1 9 GO:0019957 C-C chemokine binding 2/347 24/18367 0.0747908034842827 0.430289947318665 CXCR4/CCR7 2 GO:0070003 threonine-type peptidase activity 2/347 24/18367 0.0747908034842827 0.430289947318665 PSMB9/PSMB8 2 GO:0030247 polysaccharide binding 2/347 25/18367 0.0803118068304069 0.454743686501144 HLA-DRA/HLA-DRB1 2 GO:0140030 modification-dependent protein binding 6/347 160/18367 0.0834149448630591 0.454743686501144 LAPTM5/LYN/PTPN6/KMT2E/KMT2A/UBXN1 6 GO:0051219 phosphoprotein binding 4/347 88/18367 0.0853358941303608 0.454743686501144 LYN/PTPN6/SYK/EPB41 4 GO:0005080 protein kinase C binding 3/347 55/18367 0.0855871531489235 0.454743686501144 PRKCB/PLEK/HINT1 3 GO:0001637 G protein-coupled chemoattractant receptor activity 2/347 26/18367 0.0859546789056643 0.454743686501144 CXCR4/CCR7 2 GO:0004950 chemokine receptor activity 2/347 26/18367 0.0859546789056643 0.454743686501144 CXCR4/CCR7 2 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/347 124/18367 0.0862267938286594 0.454743686501144 BTK/LYN/JAK1/SYK/CSK 5 GO:0003730 mRNA 3'-UTR binding 7/347 201/18367 0.0875513383856326 0.456296975351003 RPL41/RPL5/CELF2/ZFP36L2/PABPC1/RPS7/DDX5 7 GO:0030507 spectrin binding 2/347 27/18367 0.0917128758906152 0.472427953715611 PTPRC/EPB41 2 GO:0004536 deoxyribonuclease activity 3/347 57/18367 0.0929297050888333 0.47319378568222 ISG20/RPS3/MBD4 3 GO:0001968 fibronectin binding 2/347 28/18367 0.0975800564503276 0.480310722305501 ITGA4/PLEKHA2 2 GO:0043236 laminin binding 2/347 28/18367 0.0975800564503276 0.480310722305501 RPSA/PLEKHA2 2 GO:0051861 glycolipid binding 2/347 28/18367 0.0975800564503276 0.480310722305501 SELL/LYN 2 GO:0036002 pre-mRNA binding 3/347 59/18367 0.100522472313972 0.484142152180406 CELF2/DDX5/SF1 3 GO:0005096 GTPase activator activity 13/347 462/18367 0.100544194132274 0.484142152180406 RALGPS2/TBC1D10C/RASGRP2/ARHGDIB/SMAP2/EEF1B2/ACAP1/TAGAP/SH3BP5/EEF1D/JUN/MYCBP2/ITSN2 13 GO:0046625 sphingolipid binding 2/347 29/18367 0.103550076455782 0.488007275211826 SELL/LYN 2 GO:0051059 NF-kappaB binding 2/347 29/18367 0.103550076455782 0.488007275211826 MTDH/COMMD6 2 GO:0004713 protein tyrosine kinase activity 5/347 136/18367 0.115628297756668 0.53425344783723 BTK/LYN/JAK1/SYK/CSK 5 GO:0031210 phosphatidylcholine binding 2/347 31/18367 0.115775013526804 0.53425344783723 IGHM/JCHAIN 2 GO:0005154 epidermal growth factor receptor binding 2/347 33/18367 0.12834228546363 0.580159514901918 MS4A1/SNX2 2 GO:0031369 translation initiation factor binding 2/347 33/18367 0.12834228546363 0.580159514901918 HHEX/RPS24 2 GO:0019199 transmembrane receptor protein kinase activity 5/347 143/18367 0.13471301579477 0.596902138882485 BTK/LYN/JAK1/SYK/CSK 5 GO:0030291 protein serine/threonine kinase inhibitor activity 2/347 34/18367 0.134740889138259 0.596902138882485 CDKN2D/PKIG 2 GO:0003712 transcription coregulator activity 13/347 489/18367 0.137239668762745 0.59739105311482 ETS1/PRKCB/BTG1/MTDH/TRIM22/TRIM38/BTG2/PFDN5/N4BP2L2/JMJD1C/UXT/ATF7IP/SF1 13 GO:0016922 nuclear receptor binding 5/347 144/18367 0.137548278595286 0.59739105311482 PRKCB/DDX5/FOXP1/JMJD1C/JUND 5 GO:0005539 glycosaminoglycan binding 7/347 230/18367 0.14644874192649 0.625926276627164 IGHM/JCHAIN/SELL/PTPRC/RPL29/RPL22/CD44 7 GO:0000217 DNA secondary structure binding 2/347 36/18367 0.147742703094495 0.625926276627164 MEF2C/KMT2A 2 GO:0008047 enzyme activator activity 4/347 110/18367 0.155062182051526 0.625926276627164 NCF1/BTK/GMFG/ALOX5AP 4 GO:0019903 protein phosphatase binding 5/347 150/18367 0.155099981430838 0.625926276627164 CD22/PHACTR1/JAK1/CSK/BOD1L1 5 GO:0000049 tRNA binding 3/347 72/18367 0.155210561777845 0.625926276627164 RPL35A/EEF1A1/EIF2S3 3 GO:0004520 endodeoxyribonuclease activity 2/347 38/18367 0.160985443163488 0.625926276627164 RPS3/MBD4 2 GO:0019902 phosphatase binding 6/347 196/18367 0.167537404998909 0.625926276627164 CD22/PHACTR1/JAK1/SYK/CSK/BOD1L1 6 GO:0050997 quaternary ammonium group binding 2/347 39/18367 0.167685786016518 0.625926276627164 IGHM/JCHAIN 2 GO:0001618 virus receptor activity 3/347 76/18367 0.173593669501578 0.625926276627164 CXCR4/RPSA/TNFRSF14 3 GO:0004690 cyclic nucleotide-dependent protein kinase activity 1/347 10/18367 0.173686002231374 0.625926276627164 PRKACB 1 GO:0005031 tumor necrosis factor-activated receptor activity 1/347 10/18367 0.173686002231374 0.625926276627164 TNFRSF14 1 GO:0008172 S-methyltransferase activity 1/347 10/18367 0.173686002231374 0.625926276627164 KMT2A 1 GO:0008190 eukaryotic initiation factor 4E binding 1/347 10/18367 0.173686002231374 0.625926276627164 HHEX 1 GO:0015279 store-operated calcium channel activity 1/347 10/18367 0.173686002231374 0.625926276627164 ORAI2 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/347 10/18367 0.173686002231374 0.625926276627164 NCF1 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/347 10/18367 0.173686002231374 0.625926276627164 ATM 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/347 10/18367 0.173686002231374 0.625926276627164 QRSL1 1 GO:0019869 chloride channel inhibitor activity 1/347 10/18367 0.173686002231374 0.625926276627164 STX7 1 GO:0032356 oxidized DNA binding 1/347 10/18367 0.173686002231374 0.625926276627164 RPS3 1 GO:0034511 U3 snoRNA binding 1/347 10/18367 0.173686002231374 0.625926276627164 ISG20 1 GO:0005543 phospholipid binding 12/347 466/18367 0.173789914277971 0.625926276627164 IGHM/JCHAIN/NCF1/BTK/SNX2/DAPP1/EPB41/FCHSD2/GGA2/AIDA/MTSS1/APPL1 12 GO:0140272 exogenous protein binding 3/347 77/18367 0.178282648488609 0.633434723638233 CXCR4/RPSA/TNFRSF14 3 GO:0048487 beta-tubulin binding 2/347 41/18367 0.181222967865605 0.633434723638233 UXT/APPL1 2 GO:0005516 calmodulin binding 6/347 201/18367 0.181358197916139 0.633434723638233 MBP/DDX5/MARCKSL1/CNN2/EPB41/PPP3CA 6 GO:0003924 GTPase activity 9/347 337/18367 0.189274552142499 0.633434723638233 RAC2/RHOH/ARHGDIB/EEF1A1/TUBA1A/RGS19/EEF2/EIF2S3/MX1 9 GO:0008603 cAMP-dependent protein kinase regulator activity 1/347 11/18367 0.189305709004033 0.633434723638233 PKIG 1 GO:0140036 ubiquitin-dependent protein binding 1/347 11/18367 0.189305709004033 0.633434723638233 LAPTM5 1 GO:1990459 transferrin receptor binding 1/347 11/18367 0.189305709004033 0.633434723638233 SNX2 1 GO:0035591 signaling adaptor activity 3/347 81/18367 0.19736980837893 0.633434723638233 BANK1/BLNK/CDC42SE2 3 GO:0001784 phosphotyrosine residue binding 2/347 44/18367 0.201809852312139 0.633434723638233 PTPN6/SYK 2 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/347 12/18367 0.204630993323907 0.633434723638233 RPS3 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/347 12/18367 0.204630993323907 0.633434723638233 CDKN2D 1 GO:0005095 GTPase inhibitor activity 1/347 12/18367 0.204630993323907 0.633434723638233 RHOH 1 GO:0008296 3'-5'-exodeoxyribonuclease activity 1/347 12/18367 0.204630993323907 0.633434723638233 ISG20 1 GO:0035004 phosphatidylinositol 3-kinase activity 1/347 12/18367 0.204630993323907 0.633434723638233 ATM 1 GO:0035325 Toll-like receptor binding 1/347 12/18367 0.204630993323907 0.633434723638233 SYK 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 8/347 299/18367 0.206137488630435 0.633434723638233 PRKCB/MTDH/COMMD6/DDX5/JUN/FOXP1/JMJD1C/JUND 8 GO:0004864 protein phosphatase inhibitor activity 2/347 46/18367 0.215678190682366 0.633434723638233 PHACTR1/BOD1L1 2 GO:0140296 general transcription initiation factor binding 2/347 46/18367 0.215678190682366 0.633434723638233 TCF4/HHEX 2 GO:0004312 fatty acid synthase activity 1/347 13/18367 0.219667389146114 0.633434723638233 ELOVL5 1 GO:0005035 death receptor activity 1/347 13/18367 0.219667389146114 0.633434723638233 TNFRSF14 1 GO:0008253 5'-nucleotidase activity 1/347 13/18367 0.219667389146114 0.633434723638233 NT5C 1 GO:0008494 translation activator activity 1/347 13/18367 0.219667389146114 0.633434723638233 PABPC1 1 GO:0019104 DNA N-glycosylase activity 1/347 13/18367 0.219667389146114 0.633434723638233 MBD4 1 GO:0032036 myosin heavy chain binding 1/347 13/18367 0.219667389146114 0.633434723638233 CORO1A 1 GO:0032454 histone H3-methyl-lysine-9 demethylase activity 1/347 13/18367 0.219667389146114 0.633434723638233 JMJD1C 1 GO:0034236 protein kinase A catalytic subunit binding 1/347 13/18367 0.219667389146114 0.633434723638233 CSK 1 GO:0051011 microtubule minus-end binding 1/347 13/18367 0.219667389146114 0.633434723638233 NIN 1 GO:0140035 ubiquitination-like modification-dependent protein binding 1/347 13/18367 0.219667389146114 0.633434723638233 LAPTM5 1 GO:0004519 endonuclease activity 4/347 129/18367 0.22749393082928 0.633434723638233 RNASE6/RPS3/RNASET2/MBD4 4 GO:0015026 coreceptor activity 2/347 48/18367 0.229629248387101 0.633434723638233 CXCR4/ITGA4 2 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/347 88/18367 0.231840421640611 0.633434723638233 CYBA/NCF1/CYBB 3 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/347 310/18367 0.233721622913124 0.633434723638233 BCL11A/IRF8/HHEX/IFI16/JUN/FOXP1/ZEB2/PRDM2 8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/347 14/18367 0.234420326705572 0.633434723638233 BLNK 1 GO:0019992 diacylglycerol binding 1/347 14/18367 0.234420326705572 0.633434723638233 RASGRP2 1 GO:0036041 long-chain fatty acid binding 1/347 14/18367 0.234420326705572 0.633434723638233 ALOX5AP 1 GO:0071837 HMG box domain binding 1/347 14/18367 0.234420326705572 0.633434723638233 JUN 1 GO:0019212 phosphatase inhibitor activity 2/347 49/18367 0.236627747045016 0.633434723638233 PHACTR1/BOD1L1 2 GO:0001217 DNA-binding transcription repressor activity 8/347 313/18367 0.241462525050173 0.633434723638233 BCL11A/IRF8/HHEX/IFI16/JUN/FOXP1/ZEB2/PRDM2 8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/347 50/18367 0.243637492471369 0.633434723638233 CDKN2D/CCNI 2 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/347 50/18367 0.243637492471369 0.633434723638233 BANK1/MBD4 2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/347 15/18367 0.248895134455431 0.633434723638233 PDE4B 1 GO:0004953 icosanoid receptor activity 1/347 15/18367 0.248895134455431 0.633434723638233 CYSLTR1 1 GO:0005161 platelet-derived growth factor receptor binding 1/347 15/18367 0.248895134455431 0.633434723638233 LYN 1 GO:0005545 1-phosphatidylinositol binding 1/347 15/18367 0.248895134455431 0.633434723638233 EPB41 1 GO:0008252 nucleotidase activity 1/347 15/18367 0.248895134455431 0.633434723638233 NT5C 1 GO:0016846 carbon-sulfur lyase activity 1/347 15/18367 0.248895134455431 0.633434723638233 ALOX5AP 1 GO:0045125 bioactive lipid receptor activity 1/347 15/18367 0.248895134455431 0.633434723638233 S1PR4 1 GO:0050998 nitric-oxide synthase binding 1/347 15/18367 0.248895134455431 0.633434723638233 CD74 1 GO:0071933 Arp2/3 complex binding 1/347 15/18367 0.248895134455431 0.633434723638233 GMFG 1 GO:1904680 peptide transmembrane transporter activity 1/347 15/18367 0.248895134455431 0.633434723638233 TAPBP 1 GO:0051018 protein kinase A binding 2/347 51/18367 0.250655571182816 0.633434723638233 RPS3/CSK 2 GO:0043130 ubiquitin binding 3/347 92/18367 0.252005698127025 0.633434723638233 CXCR4/GGA2/UBXN1 3 GO:0030246 carbohydrate binding 7/347 271/18367 0.253271150594008 0.633434723638233 HLA-DRA/FCER2/CD22/HLA-DRB1/SELL/CLEC2D/CD69 7 GO:0004698 calcium-dependent protein kinase C activity 1/347 16/18367 0.263097040969379 0.633434723638233 PRKCB 1 GO:0005092 GDP-dissociation inhibitor activity 1/347 16/18367 0.263097040969379 0.633434723638233 ARHGDIB 1 GO:0005521 lamin binding 1/347 16/18367 0.263097040969379 0.633434723638233 TMPO 1 GO:0008191 metalloendopeptidase inhibitor activity 1/347 16/18367 0.263097040969379 0.633434723638233 BST2 1 GO:0016004 phospholipase activator activity 1/347 16/18367 0.263097040969379 0.633434723638233 BTK 1 GO:0035173 histone kinase activity 1/347 16/18367 0.263097040969379 0.633434723638233 PRKCB 1 GO:0035497 cAMP response element binding 1/347 16/18367 0.263097040969379 0.633434723638233 JUN 1 GO:0070492 oligosaccharide binding 1/347 16/18367 0.263097040969379 0.633434723638233 SELL 1 GO:0017069 snRNA binding 2/347 53/18367 0.264705598902536 0.633862596290938 ISG20/LSM10 2 GO:0004697 protein kinase C activity 1/347 17/18367 0.277031176808496 0.642538279194573 PRKCB 1 GO:0016722 oxidoreductase activity, acting on metal ions 1/347 17/18367 0.277031176808496 0.642538279194573 CYB561A3 1 GO:0017081 chloride channel regulator activity 1/347 17/18367 0.277031176808496 0.642538279194573 STX7 1 GO:0042800 histone methyltransferase activity (H3-K4 specific) 1/347 17/18367 0.277031176808496 0.642538279194573 KMT2A 1 GO:0043395 heparan sulfate proteoglycan binding 1/347 17/18367 0.277031176808496 0.642538279194573 PTPRC 1 GO:0070064 proline-rich region binding 1/347 17/18367 0.277031176808496 0.642538279194573 CSK 1 GO:0015631 tubulin binding 9/347 375/18367 0.279567003824268 0.643906206622594 LYN/RPS3/OFD1/STRBP/PDE4B/MX1/UXT/NIN/APPL1 9 GO:0030374 nuclear receptor coactivator activity 2/347 56/18367 0.285776212498761 0.643906206622594 ETS1/PRKCB 2 GO:0042054 histone methyltransferase activity 2/347 56/18367 0.285776212498761 0.643906206622594 KMT2A/PRDM2 2 GO:0045309 protein phosphorylated amino acid binding 2/347 56/18367 0.285776212498761 0.643906206622594 PTPN6/SYK 2 GO:0050840 extracellular matrix binding 2/347 56/18367 0.285776212498761 0.643906206622594 RPSA/PLEKHA2 2 GO:0008022 protein C-terminus binding 5/347 189/18367 0.286728997289179 0.643906206622594 TCF4/CORO1A/PABPC1/EPB41/CSK 5 GO:0008301 DNA binding, bending 1/347 18/18367 0.290702576353316 0.643906206622594 HHEX 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/347 18/18367 0.290702576353316 0.643906206622594 DAZAP2 1 GO:0060229 lipase activator activity 1/347 18/18367 0.290702576353316 0.643906206622594 BTK 1 GO:0052742 phosphatidylinositol kinase activity 1/347 19/18367 0.304116179601743 0.670266007778966 ATM 1 GO:0043021 ribonucleoprotein complex binding 4/347 149/18367 0.310810024102513 0.675505078416174 RPSA/DDX5/RPLP1/EEF2 4 GO:0051020 GTPase binding 7/347 291/18367 0.312182680977204 0.675505078416174 RHOH/ARHGDIB/LCP1/WAS/GGA2/CDC42SE2/MYCBP2 7 GO:0140677 molecular function activator activity 4/347 150/18367 0.31507605266886 0.675505078416174 NCF1/BTK/GMFG/ALOX5AP 4 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/347 20/18367 0.317276833933452 0.675505078416174 TCF4 1 GO:0016018 cyclosporin A binding 1/347 20/18367 0.317276833933452 0.675505078416174 PPP3CA 1 GO:0030506 ankyrin binding 1/347 20/18367 0.317276833933452 0.675505078416174 PTPRC 1 GO:0031681 G-protein beta-subunit binding 1/347 20/18367 0.317276833933452 0.675505078416174 GNG7 1 GO:1990782 protein tyrosine kinase binding 3/347 105/18367 0.31883857706793 0.675505078416174 BANK1/BLNK/DAZAP2 3 GO:1990841 promoter-specific chromatin binding 2/347 62/18367 0.327671098329484 0.675505078416174 IKZF3/DDX5 2 GO:0019208 phosphatase regulator activity 3/347 107/18367 0.329193395518809 0.675505078416174 PHACTR1/BOD1L1/ZEB2 3 GO:0001614 purinergic nucleotide receptor activity 1/347 21/18367 0.330189295841398 0.675505078416174 P2RX5 1 GO:0016502 nucleotide receptor activity 1/347 21/18367 0.330189295841398 0.675505078416174 P2RX5 1 GO:0070577 lysine-acetylated histone binding 1/347 21/18367 0.330189295841398 0.675505078416174 KMT2A 1 GO:0140033 acetylation-dependent protein binding 1/347 21/18367 0.330189295841398 0.675505078416174 KMT2A 1 GO:0004602 glutathione peroxidase activity 1/347 22/18367 0.342858232631055 0.675505078416174 ALOX5AP 1 GO:0005540 hyaluronic acid binding 1/347 22/18367 0.342858232631055 0.675505078416174 CD44 1 GO:0008320 protein transmembrane transporter activity 1/347 22/18367 0.342858232631055 0.675505078416174 TOMM7 1 GO:0033691 sialic acid binding 1/347 22/18367 0.342858232631055 0.675505078416174 CD22 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/347 22/18367 0.342858232631055 0.675505078416174 BIRC3 1 GO:0032182 ubiquitin-like protein binding 3/347 111/18367 0.349886480164641 0.675505078416174 CXCR4/GGA2/UBXN1 3 GO:0002039 p53 binding 2/347 66/18367 0.355244512880261 0.675505078416174 EEF2/MDM4 2 GO:0043022 ribosome binding 2/347 66/18367 0.355244512880261 0.675505078416174 RPSA/EEF2 2 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/347 23/18367 0.355288224087965 0.675505078416174 PDE4B 1 GO:0004529 exodeoxyribonuclease activity 1/347 23/18367 0.355288224087965 0.675505078416174 ISG20 1 GO:0005158 insulin receptor binding 1/347 23/18367 0.355288224087965 0.675505078416174 SNX2 1 GO:0008143 poly(A) binding 1/347 23/18367 0.355288224087965 0.675505078416174 PABPC1 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/347 23/18367 0.355288224087965 0.675505078416174 PRKCB 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/347 23/18367 0.355288224087965 0.675505078416174 ALOX5AP 1 GO:0016849 phosphorus-oxygen lyase activity 1/347 23/18367 0.355288224087965 0.675505078416174 RNASET2 1 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/347 23/18367 0.355288224087965 0.675505078416174 ISG20 1 GO:0017025 TBP-class protein binding 1/347 23/18367 0.355288224087965 0.675505078416174 HHEX 1 GO:0030552 cAMP binding 1/347 23/18367 0.355288224087965 0.675505078416174 PDE4B 1 GO:0097110 scaffold protein binding 2/347 67/18367 0.362077384489645 0.678313781260817 LYN/SYK 2 GO:0004518 nuclease activity 5/347 210/18367 0.364674991284887 0.678313781260817 ISG20/RNASE6/RPS3/RNASET2/MBD4 5 GO:0031267 small GTPase binding 6/347 259/18367 0.364956533731354 0.678313781260817 RHOH/ARHGDIB/WAS/GGA2/CDC42SE2/MYCBP2 6 GO:0001965 G-protein alpha-subunit binding 1/347 24/18367 0.367483764114212 0.678313781260817 RGS19 1 GO:0010857 calcium-dependent protein kinase activity 1/347 24/18367 0.367483764114212 0.678313781260817 PRKCB 1 GO:0015252 proton channel activity 1/347 24/18367 0.367483764114212 0.678313781260817 HVCN1 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/347 24/18367 0.367483764114212 0.678313781260817 ALOX5AP 1 GO:0004540 ribonuclease activity 3/347 116/18367 0.37564935840083 0.683317167537099 ISG20/RNASE6/RNASET2 3 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/347 25/18367 0.379449262334371 0.683317167537099 PDE4B 1 GO:0008266 poly(U) RNA binding 1/347 25/18367 0.379449262334371 0.683317167537099 PABPC1 1 GO:0008327 methyl-CpG binding 1/347 25/18367 0.379449262334371 0.683317167537099 CXXC5 1 GO:0035035 histone acetyltransferase binding 1/347 25/18367 0.379449262334371 0.683317167537099 ETS1 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/347 25/18367 0.379449262334371 0.683317167537099 ZFP36L2 1 GO:0008201 heparin binding 4/347 166/18367 0.383648650606089 0.688082397645738 SELL/PTPRC/RPL29/RPL22 4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/347 71/18367 0.389122698304439 0.695086110277687 GLS/HINT1 2 GO:0004364 glutathione transferase activity 1/347 26/18367 0.391189045671519 0.695970872419611 ALOX5AP 1 GO:0106306 protein serine phosphatase activity 2/347 73/18367 0.402455431416475 0.707933969972146 PPM1K/PPP3CA 2 GO:0106307 protein threonine phosphatase activity 2/347 73/18367 0.402455431416475 0.707933969972146 PPM1K/PPP3CA 2 GO:0022884 macromolecule transmembrane transporter activity 1/347 27/18367 0.402707359893862 0.707933969972146 TOMM7 1 GO:0051082 unfolded protein binding 3/347 122/18367 0.406280500044406 0.711392338022418 NACA/TAPBP/PFDN5 3 GO:0017022 myosin binding 2/347 74/18367 0.409070172426251 0.713457033011138 CXCR4/CORO1A 2 GO:0003953 NAD+ nucleosidase activity 1/347 28/18367 0.414008371132511 0.713640888761488 BANK1 1 GO:0008187 poly-pyrimidine tract binding 1/347 28/18367 0.414008371132511 0.713640888761488 PABPC1 1 GO:0046875 ephrin receptor binding 1/347 28/18367 0.414008371132511 0.713640888761488 LYN 1 GO:0004721 phosphoprotein phosphatase activity 4/347 174/18367 0.417743731025961 0.715607458933666 PTPRC/PPM1K/PTPN6/PPP3CA 4 GO:0005525 GTP binding 8/347 377/18367 0.41986038094903 0.715607458933666 RAC2/RHOH/EEF1A1/TUBA1A/EEF2/EIF2S3/MX1/NIN 8 GO:0005231 excitatory extracellular ligand-gated ion channel activity 1/347 29/18367 0.425096167370966 0.715607458933666 P2RX5 1 GO:0032452 histone demethylase activity 1/347 29/18367 0.425096167370966 0.715607458933666 JMJD1C 1 GO:0070717 poly-purine tract binding 1/347 29/18367 0.425096167370966 0.715607458933666 PABPC1 1 GO:0140457 protein demethylase activity 1/347 29/18367 0.425096167370966 0.715607458933666 JMJD1C 1 GO:0009055 electron transfer activity 3/347 126/18367 0.42645681525618 0.715607458933666 CYBA/NCF1/CYBB 3 GO:0003724 RNA helicase activity 2/347 77/18367 0.428695328735842 0.716649172188596 DDX5/EIF4A2 2 GO:0030971 receptor tyrosine kinase binding 2/347 78/18367 0.435160834112718 0.723358871306052 BLNK/DAZAP2 2 GO:0046966 thyroid hormone receptor binding 1/347 30/18367 0.435974759906808 0.723358871306052 JMJD1C 1 GO:0008186 ATP-dependent activity, acting on RNA 2/347 79/18367 0.441586759157187 0.724780591795827 DDX5/EIF4A2 2 GO:0046332 SMAD binding 2/347 79/18367 0.441586759157187 0.724780591795827 DDX5/JUN 2 GO:0004674 protein serine/threonine kinase activity 8/347 386/18367 0.445630515873569 0.724780591795827 PRKCB/STK17B/STK4/SYK/PRKACB/ATM/CSNK1G3/STK17A 8 GO:0005164 tumor necrosis factor receptor binding 1/347 31/18367 0.446648084786141 0.724780591795827 LTB 1 GO:0008157 protein phosphatase 1 binding 1/347 31/18367 0.446648084786141 0.724780591795827 PHACTR1 1 GO:0140318 protein transporter activity 1/347 31/18367 0.446648084786141 0.724780591795827 TOMM7 1 GO:0030515 snoRNA binding 1/347 32/18367 0.457120004211273 0.728432236926596 ISG20 1 GO:0050699 WW domain binding 1/347 32/18367 0.457120004211273 0.728432236926596 DAZAP2 1 GO:0051721 protein phosphatase 2A binding 1/347 32/18367 0.457120004211273 0.728432236926596 BOD1L1 1 GO:0071889 14-3-3 protein binding 1/347 32/18367 0.457120004211273 0.728432236926596 HLA-F 1 GO:0140658 ATP-dependent chromatin remodeler activity 1/347 32/18367 0.457120004211273 0.728432236926596 CHD9 1 GO:0001530 lipopolysaccharide binding 1/347 33/18367 0.467394307922137 0.739484565748237 ZRANB2 1 GO:0051427 hormone receptor binding 1/347 33/18367 0.467394307922137 0.739484565748237 JAK1 1 GO:0002020 protease binding 3/347 135/18367 0.47090813028393 0.742392532796373 BANK1/SELL/MBP 3 GO:0001540 amyloid-beta binding 2/347 84/18367 0.473095719016165 0.743196466397734 CD74/PFDN5 2 GO:0043548 phosphatidylinositol 3-kinase binding 1/347 34/18367 0.477474714551951 0.745656242032792 CORO1A 1 GO:0019001 guanyl nucleotide binding 8/347 398/18367 0.479711126364212 0.745656242032792 RAC2/RHOH/EEF1A1/TUBA1A/EEF2/EIF2S3/MX1/NIN 8 GO:0032561 guanyl ribonucleotide binding 8/347 398/18367 0.479711126364212 0.745656242032792 RAC2/RHOH/EEF1A1/TUBA1A/EEF2/EIF2S3/MX1/NIN 8 GO:0000175 3'-5'-exoribonuclease activity 1/347 35/18367 0.487364872957584 0.750345637621107 ISG20 1 GO:0042887 amide transmembrane transporter activity 1/347 35/18367 0.487364872957584 0.750345637621107 TAPBP 1 GO:0030674 protein-macromolecule adaptor activity 6/347 296/18367 0.488572795794256 0.750345637621107 JCHAIN/BANK1/TRIM22/BLNK/STX7/CDC42SE2 6 GO:0099106 ion channel regulator activity 3/347 139/18367 0.490165823622624 0.750345637621107 PRKCB/FXYD5/STX7 3 GO:0003727 single-stranded RNA binding 2/347 87/18367 0.491480609476219 0.750345637621107 PABPC1/STRBP 2 GO:0005484 SNAP receptor activity 1/347 36/18367 0.497068363525101 0.750345637621107 STX7 1 GO:0043394 proteoglycan binding 1/347 36/18367 0.497068363525101 0.750345637621107 PTPRC 1 GO:0008276 protein methyltransferase activity 2/347 88/18367 0.497518753379373 0.750345637621107 KMT2A/PRDM2 2 GO:0019838 growth factor binding 3/347 141/18367 0.499665830921504 0.750345637621107 IL2RG/RPS2/RPS19 3 GO:0070851 growth factor receptor binding 3/347 141/18367 0.499665830921504 0.750345637621107 MS4A1/LYN/SNX2 3 GO:0019888 protein phosphatase regulator activity 2/347 89/18367 0.503511026657487 0.751028231681032 PHACTR1/BOD1L1 2 GO:0051117 ATPase binding 2/347 89/18367 0.503511026657487 0.751028231681032 PPP3CA/UBXN1 2 GO:0030551 cyclic nucleotide binding 1/347 37/18367 0.506588699450953 0.753083200861651 PDE4B 1 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters 1/347 38/18367 0.515929327999263 0.758332127801123 ISG20 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/347 38/18367 0.515929327999263 0.758332127801123 RPS3 1 GO:0016247 channel regulator activity 3/347 145/18367 0.518392422427138 0.758332127801123 PRKCB/FXYD5/STX7 3 GO:0051213 dioxygenase activity 2/347 92/18367 0.521208526233337 0.758332127801123 ALOX5AP/JMJD1C 2 GO:0106310 protein serine kinase activity 7/347 360/18367 0.522652943481626 0.758332127801123 PRKCB/STK17B/STK4/PRKACB/ATM/CSNK1G3/STK17A 7 GO:0004402 histone acetyltransferase activity 1/347 39/18367 0.525093631735651 0.758332127801123 EPC1 1 GO:0005504 fatty acid binding 1/347 39/18367 0.525093631735651 0.758332127801123 ALOX5AP 1 GO:0032451 demethylase activity 1/347 39/18367 0.525093631735651 0.758332127801123 JMJD1C 1 GO:0008528 G protein-coupled peptide receptor activity 3/347 147/18367 0.527613346036493 0.758332127801123 CXCR4/CCR7/CYSLTR1 3 GO:0004532 exoribonuclease activity 1/347 40/18367 0.534084929738037 0.758332127801123 ISG20 1 GO:0017080 sodium channel regulator activity 1/347 40/18367 0.534084929738037 0.758332127801123 FXYD5 1 GO:0043014 alpha-tubulin binding 1/347 40/18367 0.534084929738037 0.758332127801123 OFD1 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/347 40/18367 0.534084929738037 0.758332127801123 BIRC3 1 GO:0044183 protein folding chaperone 1/347 40/18367 0.534084929738037 0.758332127801123 CD74 1 GO:0061733 peptide-lysine-N-acetyltransferase activity 1/347 41/18367 0.542906478784847 0.768394792657148 EPC1 1 GO:0060090 molecular adaptor activity 7/347 369/18367 0.548862144564495 0.770507771126939 JCHAIN/BANK1/TRIM22/BLNK/STX7/CDC42SE2/ITSN2 7 GO:0001046 core promoter sequence-specific DNA binding 1/347 42/18367 0.55156147452105 0.770507771126939 FOXP1 1 GO:0019205 nucleobase-containing compound kinase activity 1/347 42/18367 0.55156147452105 0.770507771126939 DCK 1 GO:0003713 transcription coactivator activity 5/347 262/18367 0.553468348345117 0.770507771126939 ETS1/PRKCB/MTDH/TRIM22/TRIM38 5 GO:0001653 peptide receptor activity 3/347 153/18367 0.554676890406761 0.770507771126939 CXCR4/CCR7/CYSLTR1 3 GO:0004722 protein serine/threonine phosphatase activity 2/347 98/18367 0.55531725444961 0.770507771126939 PPM1K/PPP3CA 2 GO:0005246 calcium channel regulator activity 1/347 43/18367 0.560053052602425 0.770507771126939 PRKCB 1 GO:0018024 histone-lysine N-methyltransferase activity 1/347 43/18367 0.560053052602425 0.770507771126939 KMT2A 1 GO:0030544 Hsp70 protein binding 1/347 43/18367 0.560053052602425 0.770507771126939 RPS3 1 GO:0004386 helicase activity 3/347 156/18367 0.567858475786369 0.777142717251809 DDX5/EIF4A2/CHD9 3 GO:0051879 Hsp90 protein binding 1/347 44/18367 0.568384289818479 0.777142717251809 RPS3 1 GO:0004725 protein tyrosine phosphatase activity 2/347 102/18367 0.577083720762437 0.786609502454645 PTPRC/PTPN6 2 GO:0008017 microtubule binding 5/347 271/18367 0.583529201396094 0.792955325823527 RPS3/STRBP/MX1/UXT/NIN 5 GO:0035254 glutamate receptor binding 1/347 47/18367 0.592445864173141 0.802610146265142 MYL12A 1 GO:0016791 phosphatase activity 5/347 275/18367 0.596536527427737 0.803242469546968 PTPRC/PPM1K/PTPN6/PPP3CA/NT5C 5 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/347 48/18367 0.600165366636674 0.803242469546968 QRSL1 1 GO:0048020 CCR chemokine receptor binding 1/347 48/18367 0.600165366636674 0.803242469546968 JAK1 1 GO:0070888 E-box binding 1/347 48/18367 0.600165366636674 0.803242469546968 TCF4 1 GO:0032813 tumor necrosis factor receptor superfamily binding 1/347 49/18367 0.607739067044833 0.8084937138164 LTB 1 GO:0034212 peptide N-acetyltransferase activity 1/347 49/18367 0.607739067044833 0.8084937138164 EPC1 1 GO:0030159 signaling receptor complex adaptor activity 1/347 50/18367 0.615169711423883 0.813493081076956 BLNK 1 GO:0140359 ABC-type transporter activity 1/347 50/18367 0.615169711423883 0.813493081076956 TAPBP 1 GO:0004601 peroxidase activity 1/347 51/18367 0.622459994228705 0.820683861438441 ALOX5AP 1 GO:0031593 polyubiquitin modification-dependent protein binding 1/347 52/18367 0.62961255930856 0.827424160568834 UBXN1 1 GO:0140097 catalytic activity, acting on DNA 4/347 229/18367 0.631307824542361 0.827424160568834 ISG20/RPS3/CHD9/MBD4 4 GO:1901981 phosphatidylinositol phosphate binding 3/347 173/18367 0.637863976807598 0.833550860547982 BTK/DAPP1/FCHSD2 3 GO:0008408 3'-5' exonuclease activity 1/347 54/18367 0.643514864331044 0.838462014407801 ISG20 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/347 55/18367 0.650269647385547 0.844778456867441 ALOX5AP 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/347 56/18367 0.656896800747125 0.850892639564259 BIRC3 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/347 58/18367 0.669777791965768 0.863440590052197 ALOX5AP 1 GO:0016279 protein-lysine N-methyltransferase activity 1/347 59/18367 0.676036304510848 0.863440590052197 KMT2A 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/347 59/18367 0.676036304510848 0.863440590052197 ISG20 1 GO:0098631 cell adhesion mediator activity 1/347 59/18367 0.676036304510848 0.863440590052197 RPSA 1 GO:0003697 single-stranded DNA binding 2/347 123/18367 0.678469005265062 0.863440590052197 IGHM/JCHAIN 2 GO:0001786 phosphatidylserine binding 1/347 60/18367 0.682176538415957 0.863440590052197 APPL1 1 GO:0016278 lysine N-methyltransferase activity 1/347 60/18367 0.682176538415957 0.863440590052197 KMT2A 1 GO:0032934 sterol binding 1/347 60/18367 0.682176538415957 0.863440590052197 GPR183 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/347 125/18367 0.68701456145027 0.866116250407834 GLS/HINT1 2 GO:0043621 protein self-association 1/347 61/18367 0.688200722671688 0.866116250407834 FOXP1 1 GO:0042578 phosphoric ester hydrolase activity 6/347 366/18367 0.693168452462906 0.869896953090842 PTPRC/PPM1K/PTPN6/PDE4B/PPP3CA/NT5C 6 GO:0042826 histone deacetylase binding 2/347 127/18367 0.695373149959338 0.870198602915217 MEF2C/IKZF3 2 GO:0016829 lyase activity 3/347 196/18367 0.719343733376576 0.8885936456817 ALOX5AP/RPS3/RNASET2 3 GO:0044325 transmembrane transporter binding 2/347 133/18367 0.719347463466802 0.8885936456817 LYN/PDE4B 2 GO:0003684 damaged DNA binding 1/347 68/18367 0.727299256081431 0.8885936456817 RPS3 1 GO:0008080 N-acetyltransferase activity 1/347 68/18367 0.727299256081431 0.8885936456817 EPC1 1 GO:0051536 iron-sulfur cluster binding 1/347 68/18367 0.727299256081431 0.8885936456817 RPS3 1 GO:0051540 metal cluster binding 1/347 68/18367 0.727299256081431 0.8885936456817 RPS3 1 GO:0004521 endoribonuclease activity 1/347 69/18367 0.732470421617238 0.8885936456817 RNASET2 1 GO:0005518 collagen binding 1/347 69/18367 0.732470421617238 0.8885936456817 CD44 1 GO:0001098 basal transcription machinery binding 1/347 70/18367 0.737543804702757 0.8885936456817 TCF4 1 GO:0001099 basal RNA polymerase II transcription machinery binding 1/347 70/18367 0.737543804702757 0.8885936456817 TCF4 1 GO:0140098 catalytic activity, acting on RNA 6/347 386/18367 0.740481914239385 0.8885936456817 ISG20/RNASE6/DDX5/QRSL1/RNASET2/EIF4A2 6 GO:1901681 sulfur compound binding 4/347 265/18367 0.740599989007929 0.8885936456817 SELL/PTPRC/RPL29/RPL22 4 GO:0020037 heme binding 2/347 139/18367 0.741716576070862 0.8885936456817 CYBA/CYBB 2 GO:0046982 protein heterodimerization activity 5/347 328/18367 0.745504706828948 0.8885936456817 MEF2C/TCF4/CYBA/CYBB/SNX2 5 GO:0003678 DNA helicase activity 1/347 72/18367 0.74740456382459 0.8885936456817 CHD9 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/347 72/18367 0.74740456382459 0.8885936456817 CYB561A3 1 GO:0042379 chemokine receptor binding 1/347 72/18367 0.74740456382459 0.8885936456817 JAK1 1 GO:0005230 extracellular ligand-gated ion channel activity 1/347 73/18367 0.752195523996925 0.8885936456817 P2RX5 1 GO:0033293 monocarboxylic acid binding 1/347 73/18367 0.752195523996925 0.8885936456817 ALOX5AP 1 GO:0035064 methylated histone binding 1/347 73/18367 0.752195523996925 0.8885936456817 KMT2E 1 GO:0140034 methylation-dependent protein binding 1/347 73/18367 0.752195523996925 0.8885936456817 KMT2E 1 GO:0019905 syntaxin binding 1/347 74/18367 0.756895871278714 0.889725155369721 STX7 1 GO:0016887 ATP hydrolysis activity 4/347 272/18367 0.758726626071002 0.889725155369721 DDX5/EIF4A2/CHD9/SMCHD1 4 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/347 144/18367 0.759178575010733 0.889725155369721 BANK1/MBD4 2 GO:0046906 tetrapyrrole binding 2/347 149/18367 0.775611961811669 0.906586013410473 CYBA/CYBB 2 GO:0016835 carbon-oxygen lyase activity 1/347 79/18367 0.779097114602541 0.908263215181383 RPS3 1 GO:0004527 exonuclease activity 1/347 80/18367 0.783288568082031 0.910752849502204 ISG20 1 GO:0030165 PDZ domain binding 1/347 84/18367 0.799276158266814 0.926476555005047 PLEKHA2 1 GO:0008013 beta-catenin binding 1/347 85/18367 0.803085772284285 0.926476555005047 TCF4 1 GO:0050660 flavin adenine dinucleotide binding 1/347 85/18367 0.803085772284285 0.926476555005047 CYBB 1 GO:0016209 antioxidant activity 1/347 86/18367 0.80682328661627 0.928370690833786 ALOX5AP 1 GO:0048306 calcium-dependent protein binding 1/347 88/18367 0.814087433294524 0.93430241696755 DDX5 1 GO:0008081 phosphoric diester hydrolase activity 1/347 89/18367 0.817616710642672 0.935928172647814 PDE4B 1 GO:0016407 acetyltransferase activity 1/347 91/18367 0.824476100243525 0.941347712391447 EPC1 1 GO:0061630 ubiquitin protein ligase activity 4/347 304/18367 0.829319512238649 0.944019625303797 BIRC3/TRIM22/TRIM38/MYCBP2 4 GO:0072341 modified amino acid binding 1/347 93/18367 0.831078225436751 0.944019625303797 APPL1 1 GO:0016410 N-acyltransferase activity 1/347 94/18367 0.83428583492419 0.945239449799018 EPC1 1 GO:0042393 histone binding 3/347 244/18367 0.842850880244485 0.950870543382164 PRKCB/KMT2E/KMT2A 3 GO:0008170 N-methyltransferase activity 1/347 97/18367 0.843548811623454 0.950870543382164 KMT2A 1 GO:0031406 carboxylic acid binding 2/347 176/18367 0.848395787106613 0.95345169619533 CD22/ALOX5AP 2 GO:0061659 ubiquitin-like protein ligase activity 4/347 316/18367 0.850972234180307 0.95345169619533 BIRC3/TRIM22/TRIM38/MYCBP2 4 GO:0005496 steroid binding 1/347 100/18367 0.852295421429686 0.95345169619533 GPR183 1 GO:0004866 endopeptidase inhibitor activity 2/347 180/18367 0.857143899143443 0.95545259714468 BIRC3/BST2 2 GO:0015399 primary active transmembrane transporter activity 2/347 181/18367 0.859257849822408 0.95545259714468 CYB561A3/TAPBP 2 GO:0031490 chromatin DNA binding 1/347 103/18367 0.860554370791709 0.95545259714468 JMJD1C 1 GO:0051087 chaperone binding 1/347 107/18367 0.87085436750439 0.962616378737422 HLA-B 1 GO:0030414 peptidase inhibitor activity 2/347 187/18367 0.871352523416944 0.962616378737422 BIRC3/BST2 2 GO:0042626 ATPase-coupled transmembrane transporter activity 1/347 109/18367 0.875716244406414 0.963000615363075 TAPBP 1 GO:0000149 SNARE binding 1/347 110/18367 0.878078302857009 0.963000615363075 STX7 1 GO:0004222 metalloendopeptidase activity 1/347 111/18367 0.880395596438026 0.963000615363075 ADAM28 1 GO:0008094 ATP-dependent activity, acting on DNA 1/347 111/18367 0.880395596438026 0.963000615363075 CHD9 1 GO:0061135 endopeptidase regulator activity 2/347 194/18367 0.884253306210631 0.963170444239665 BIRC3/BST2 2 GO:0099094 ligand-gated cation channel activity 1/347 113/18367 0.88489925689739 0.963170444239665 P2RX5 1 GO:0005126 cytokine receptor binding 3/347 271/18367 0.889198797524186 0.96547810613533 LTB/JAK1/SYK 3 GO:0005244 voltage-gated ion channel activity 2/347 201/18367 0.895950106838453 0.967292819363292 HVCN1/CYBB 2 GO:0022832 voltage-gated channel activity 2/347 201/18367 0.895950106838453 0.967292819363292 HVCN1/CYBB 2 GO:0005262 calcium channel activity 1/347 119/18367 0.897420651824635 0.967292819363292 ORAI2 1 GO:0140101 catalytic activity, acting on a tRNA 1/347 124/18367 0.906810834563452 0.975041746872838 QRSL1 1 GO:0008168 methyltransferase activity 2/347 214/18367 0.914810009565429 0.977224992786382 KMT2A/PRDM2 2 GO:0031072 heat shock protein binding 1/347 129/18367 0.915343682996041 0.977224992786382 RPS3 1 GO:0015078 proton transmembrane transporter activity 1/347 130/18367 0.916954371777726 0.977224992786382 HVCN1 1 GO:0000287 magnesium ion binding 2/347 221/18367 0.923589548635397 0.977224992786382 STK4/PRKACB 2 GO:0015085 calcium ion transmembrane transporter activity 1/347 135/18367 0.924560835945257 0.977224992786382 ORAI2 1 GO:0043177 organic acid binding 1/347 135/18367 0.924560835945257 0.977224992786382 ALOX5AP 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/347 222/18367 0.924772039095393 0.977224992786382 ELOVL5/EPC1 2 GO:0016741 transferase activity, transferring one-carbon groups 2/347 225/18367 0.928217008427956 0.977224992786382 KMT2A/PRDM2 2 GO:0061134 peptidase regulator activity 2/347 230/18367 0.933630265401524 0.977224992786382 BIRC3/BST2 2 GO:0015276 ligand-gated ion channel activity 1/347 143/18367 0.935312408445657 0.977224992786382 P2RX5 1 GO:0022834 ligand-gated channel activity 1/347 143/18367 0.935312408445657 0.977224992786382 P2RX5 1 GO:0022843 voltage-gated cation channel activity 1/347 143/18367 0.935312408445657 0.977224992786382 HVCN1 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/347 156/18367 0.949621292733576 0.986584005296505 KMT2A 1 GO:0016746 acyltransferase activity 2/347 250/18367 0.951657516394096 0.986584005296505 ELOVL5/EPC1 2 GO:0005261 cation channel activity 3/347 335/18367 0.954044979005234 0.986584005296505 HVCN1/P2RX5/ORAI2 3 GO:0008083 growth factor activity 1/347 162/18367 0.955114138673134 0.986584005296505 GMFG 1 GO:0022836 gated channel activity 3/347 340/18367 0.95721018085355 0.986584005296505 HVCN1/P2RX5/CYBB 3 GO:0016874 ligase activity 1/347 165/18367 0.957632330197511 0.986584005296505 QRSL1 1 GO:0004842 ubiquitin-protein transferase activity 4/347 433/18367 0.965276668565291 0.992152121054348 BIRC3/TRIM22/TRIM38/MYCBP2 4 GO:0008237 metallopeptidase activity 1/347 190/18367 0.973823356661004 0.99773548273984 ADAM28 1 GO:0019787 ubiquitin-like protein transferase activity 4/347 458/18367 0.975213237079799 0.99773548273984 BIRC3/TRIM22/TRIM38/MYCBP2 4 GO:0015267 channel activity 4/347 480/18367 0.98168904137976 0.999751428517843 HVCN1/P2RX5/ORAI2/CYBB 4 GO:0022803 passive transmembrane transporter activity 4/347 481/18367 0.981941696646341 0.999751428517843 HVCN1/P2RX5/ORAI2/CYBB 4 GO:0004175 endopeptidase activity 3/347 430/18367 0.988747981812535 0.999751428517843 ADAM28/PSMB9/PSMB8 3 GO:0005125 cytokine activity 1/347 235/18367 0.989015912665649 0.999751428517843 LTB 1 GO:0005216 ion channel activity 3/347 432/18367 0.989087656135578 0.999751428517843 HVCN1/P2RX5/ORAI2 3 GO:0022804 active transmembrane transporter activity 2/347 406/18367 0.996426763269372 0.999751428517843 CYB561A3/TAPBP 2 GO:0001664 G protein-coupled receptor binding 1/347 295/18367 0.996561060483516 0.999751428517843 JAK1 1 GO:0048018 receptor ligand activity 2/347 487/18367 0.999133132846679 0.999751428517843 LTB/GMFG 2 GO:0030546 signaling receptor activator activity 2/347 495/18367 0.999247607255921 0.999751428517843 LTB/GMFG 2 GO:0046873 metal ion transmembrane transporter activity 1/347 430/18367 0.999751428517843 0.999751428517843 ORAI2 1