ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0023026	MHC class II protein complex binding	13/512	27/18367	7.41418016712081e-14	5.4864933236694e-11	CD4/ATP1B1/CD74/HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/CD81	13
GO:0023023	MHC protein complex binding	13/512	36/18367	6.78801619804797e-12	2.51156599327775e-09	CD4/ATP1B1/CD74/HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/CD81	13
GO:0140375	immune receptor activity	23/512	144/18367	1.23603043572933e-11	3.04887507479902e-09	C3AR1/LILRB5/CD4/CR1/CMKLR1/FCER1G/FCGR2B/CD74/CCR1/HLA-DRA/FCGR1B/HLA-DRB1/HLA-DQA1/IL10RA/HLA-DQB1/FPR3/C5AR1/HLA-DPA1/FPR1/IFNGR2/CD44/IL13RA1/IFNAR1	23
GO:0042605	peptide antigen binding	11/512	36/18367	2.26965975499515e-09	4.19887054674104e-07	CD209/HLA-B/HLA-DRA/HLA-A/HLA-DRB1/HLA-C/HLA-DQA1/HLA-DQB1/HLA-DPA1/HLA-E/HLA-DPB1	11
GO:0019864	IgG binding	7/512	11/18367	3.76223263348514e-09	5.568104297558e-07	FCGRT/FCGR2A/FCGR3A/FCER1G/FCGR2B/FCGR1A/FCGR1B	7
GO:0038024	cargo receptor activity	14/512	77/18367	2.40739158791674e-08	2.75718845520419e-06	MRC1/FOLR2/STAB1/CD163/ENPP2/DAB2/CD36/MSR1/ITGB2/ITGAM/CXCL16/ABCA1/COLEC12/LRP1	14
GO:0042277	peptide binding	29/512	321/18367	2.93075330241466e-08	2.75718845520419e-06	C1QA/CD14/CD209/CMKLR1/FCGR2B/APOE/CD74/CD36/MSR1/ITGB2/HLA-B/TLR4/HLA-DRA/TPP1/ITGAM/HLA-A/HLA-DRB1/HLA-C/HLA-DQA1/ITM2B/CST3/HLA-DQB1/HLA-DPA1/HLA-E/HLA-DPB1/PRNP/MGST2/LRP1/PIK3R1	29
GO:0033218	amide binding	33/512	400/18367	2.98074427589642e-08	2.75718845520419e-06	C1QA/PLTP/FOLR2/CD14/CD209/CMKLR1/FCGR2B/APOE/CD74/CD36/MSR1/ITGB2/HLA-B/TLR4/HLA-DRA/TPP1/ITGAM/HLA-A/HLA-DRB1/PSAP/HLA-C/HLA-DQA1/FKBP5/ITM2B/CST3/HLA-DQB1/HLA-DPA1/HLA-E/HLA-DPB1/PRNP/MGST2/LRP1/PIK3R1	33
GO:0004875	complement receptor activity	6/512	12/18367	3.65114879411006e-07	3.00205567515716e-05	C3AR1/CR1/CMKLR1/FPR3/C5AR1/FPR1	6
GO:0001540	amyloid-beta binding	13/512	84/18367	5.41677405020105e-07	3.78330586583405e-05	C1QA/FCGR2B/APOE/CD74/CD36/MSR1/ITGB2/TLR4/ITGAM/ITM2B/CST3/PRNP/LRP1	13
GO:0005178	integrin binding	17/512	144/18367	5.62383304380737e-07	3.78330586583405e-05	SPP1/IGF1/GPNMB/ITGB2/ICAM1/TGFBI/ITGAM/TIMP2/SYK/ADAM9/LCP1/LYN/CD81/ISG15/FERMT3/TSPAN4/ADAM10	17
GO:0017124	SH3 domain binding	16/512	130/18367	6.85857377484509e-07	4.22945382782114e-05	CYBA/SH3BGRL/WIPF1/SH3BP2/ADAM9/LYN/EPS15/SIRPA/PLSCR1/GPX1/QKI/WAS/NCF1/PTPN6/ABI1/ADAM10	16
GO:0035259	glucocorticoid receptor binding	6/512	14/18367	1.13139061819999e-06	6.27270762237226e-05	NR4A2/NRIP1/NR4A1/STAT3/ETS2/TACC1	6
GO:0001618	virus receptor activity	12/512	76/18367	1.18672846909745e-06	6.27270762237226e-05	MRC1/CD4/CD209/CR1/ICAM1/CD86/HSPA1A/SELPLG/CD81/TNFRSF14/PLSCR1/LAMP1	12
GO:0140272	exogenous protein binding	12/512	77/18367	1.37074113548168e-06	6.76232293504295e-05	MRC1/CD4/CD209/CR1/ICAM1/CD86/HSPA1A/SELPLG/CD81/TNFRSF14/PLSCR1/LAMP1	12
GO:0019955	cytokine binding	16/512	139/18367	1.69622615065629e-06	7.84504594678535e-05	CSF1R/A2M/CD4/CD74/CD36/CCR1/TNFRSF1B/IL10RA/ZFP36/NRP1/TNFRSF14/TGFBR2/ENG/TNFRSF1A/IL13RA1/IFNAR1	16
GO:0019865	immunoglobulin binding	7/512	23/18367	2.08854668073145e-06	9.09132084553688e-05	FCGRT/FCGR2A/FCGR3A/FCER1G/FCGR2B/FCGR1A/FCGR1B	7
GO:0032395	MHC class II receptor activity	5/512	10/18367	3.70513966788597e-06	0.000152322408568646	HLA-DRA/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DPA1	5
GO:0038187	pattern recognition receptor activity	7/512	26/18367	5.21133133353853e-06	0.000202967641411501	CD14/LY96/CD36/TLR4/TLR7/CLEC7A/COLEC12	7
GO:0030674	protein-macromolecule adaptor activity	23/512	296/18367	1.01923137127117e-05	0.000377115607370334	ATP1B1/GAS6/ADAP2/DAB2/AP1S2/DOK2/PAG1/TRIM22/IQGAP1/AP2A2/SDCBP/KLF4/STX7/GNB4/STAT3/FEM1B/ABI1/EPS8/PIK3R1/STX12/SERINC1/AKAP13/HERPUD1	23
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	23/512	299/18367	1.2003590345767e-05	0.000422983659803217	IFI27/RB1/RBPJ/NR4A2/SPI1/MTDH/MEF2A/FOS/ACTB/PARP9/DTX3L/KLF4/NRIP1/NR4A1/STAT1/JMJD1C/STAT3/HIF1A/ETS2/DDX5/TACC1/JUN/CITED2	23
GO:0001848	complement binding	6/512	21/18367	1.73091579070353e-05	0.000569202127463584	VSIG4/CR1/CD93/ITGB2/ITGAM/C5AR1	6
GO:0071813	lipoprotein particle binding	7/512	31/18367	1.84606095393595e-05	0.000569202127463584	PLTP/STAB1/APOE/CD36/MSR1/ABCA1/COLEC12	7
GO:0071814	protein-lipid complex binding	7/512	31/18367	1.84606095393595e-05	0.000569202127463584	PLTP/STAB1/APOE/CD36/MSR1/ABCA1/COLEC12	7
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	29/512	450/18367	2.73410881866505e-05	0.000809296210324855	MAF/MEF2C/RUNX1/MAFB/TCF4/TFEC/KLF6/RBPJ/NR4A2/SPI1/MEF2A/FOS/JUNB/EGR1/NFIC/PLSCR1/FOXO3/FOSB/TCF12/KLF4/REL/NR4A1/STAT3/HIF1A/LITAF/CEBPD/JUN/ATF5/ELF1	29
GO:0001216	DNA-binding transcription activator activity	29/512	456/18367	3.48007917518976e-05	0.000990484072938624	MAF/MEF2C/RUNX1/MAFB/TCF4/TFEC/KLF6/RBPJ/NR4A2/SPI1/MEF2A/FOS/JUNB/EGR1/NFIC/PLSCR1/FOXO3/FOSB/TCF12/KLF4/REL/NR4A1/STAT3/HIF1A/LITAF/CEBPD/JUN/ATF5/ELF1	29
GO:0003725	double-stranded RNA binding	10/512	74/18367	3.76393939732727e-05	0.0010315982051934	TLR7/OAS2/MTDH/CLTC/OAS1/VIM/MBNL1/MSN/IFIH1/ADAR	10
GO:0001846	opsonin binding	5/512	15/18367	3.93223196516224e-05	0.00103923273365002	VSIG4/CR1/CD93/ITGB2/ITGAM	5
GO:0005044	scavenger receptor activity	8/512	47/18367	4.16900139769609e-05	0.00106381414975693	STAB1/CD163/ENPP2/CD36/MSR1/CXCL16/COLEC12/LRP1	8
GO:0060090	molecular adaptor activity	25/512	369/18367	4.34469152769313e-05	0.00107169057683097	ATP1B1/GAS6/ADAP2/DAB2/ITSN1/AP1S2/DOK2/PAG1/ITSN2/TRIM22/IQGAP1/AP2A2/SDCBP/KLF4/STX7/GNB4/STAT3/FEM1B/ABI1/EPS8/PIK3R1/STX12/SERINC1/AKAP13/HERPUD1	25
GO:0140297	DNA-binding transcription factor binding	26/512	394/18367	4.77697003163847e-05	0.00107422187988264	MEF2C/IFI27/RB1/RBPJ/NR4A2/SPI1/MTDH/MEF2A/FOS/ACTB/PARP9/DTX3L/TCF12/KLF4/NRIP1/NR4A1/STAT1/JMJD1C/STAT3/HIF1A/ETS2/DDX5/USF2/TACC1/JUN/CITED2	26
GO:0030695	GTPase regulator activity	30/512	488/18367	4.79044892380095e-05	0.00107422187988264	CYTH4/ADAP2/NCKAP1L/RGL1/DENND3/ALDH1A1/RIN2/ARHGAP4/RGS1/ITSN1/CCDC88A/NRP1/PREX1/ITSN2/SIRPA/IQGAP1/ARHGAP18/RGS10/CYTH1/WAS/RASGEF1B/SMAP2/ACAP2/ARHGDIB/GPSM3/JUN/MYO9B/RANBP2/GNA13/AKAP13	30
GO:0060589	nucleoside-triphosphatase regulator activity	30/512	488/18367	4.79044892380095e-05	0.00107422187988264	CYTH4/ADAP2/NCKAP1L/RGL1/DENND3/ALDH1A1/RIN2/ARHGAP4/RGS1/ITSN1/CCDC88A/NRP1/PREX1/ITSN2/SIRPA/IQGAP1/ARHGAP18/RGS10/CYTH1/WAS/RASGEF1B/SMAP2/ACAP2/ARHGDIB/GPSM3/JUN/MYO9B/RANBP2/GNA13/AKAP13	30
GO:0043394	proteoglycan binding	7/512	36/18367	5.19439671207337e-05	0.00113054516674538	APOE/CTSS/GPNMB/CTSB/PTPRC/SDCBP/LRP1	7
GO:0008047	enzyme activator activity	12/512	110/18367	5.71130111282317e-05	0.00120753223528261	CCL3/APOE/NCF4/ALOX5AP/PSAP/NCF2/DTX3L/GMFG/NCF1/NUPR1/MGST2/CALM2	12
GO:0030169	low-density lipoprotein particle binding	5/512	17/18367	7.73664685650918e-05	0.00156988402744663	PLTP/STAB1/CD36/MSR1/COLEC12	5
GO:0005126	cytokine receptor binding	20/512	271/18367	7.84942013723317e-05	0.00156988402744663	CCL2/SPRED1/CCL3/CCL4/CCDC88A/CXCL16/SYK/TNFSF13B/JAK2/PYCARD/TGFBR2/SDCBP/ENG/SNX6/TGFB1/STAT1/IL13RA1/STAT3/FEM1B/PIK3R1	20
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/512	10/18367	0.000109648640055264	0.00208051265745886	CYBB/CYBA/NCF2/NCF1	4
GO:0034713	type I transforming growth factor beta receptor binding	4/512	10/18367	0.000109648640055264	0.00208051265745886	TGFBR2/ENG/SNX6/TGFB1	4
GO:0042608	T cell receptor binding	4/512	11/18367	0.000168512461202955	0.00311748053225467	HLA-DRA/HLA-A/HLA-DRB1/HLA-E	4
GO:0035325	Toll-like receptor binding	4/512	12/18367	0.000247210273078391	0.00446184395312219	LY96/CD36/UNC93B1/SYK	4
GO:0005096	GTPase activator activity	27/512	462/18367	0.000257698730748465	0.00454040620842533	CYTH4/ADAP2/NCKAP1L/RGL1/DENND3/ALDH1A1/RIN2/ARHGAP4/RGS1/ITSN1/CCDC88A/NRP1/PREX1/ITSN2/IQGAP1/ARHGAP18/RGS10/CYTH1/RASGEF1B/SMAP2/ACAP2/ARHGDIB/JUN/MYO9B/RANBP2/GNA13/AKAP13	27
GO:0120020	cholesterol transfer activity	5/512	22/18367	0.000293383279577019	0.00502375752377455	PLTP/APOE/NPC2/ABCA1/TSPO	5
GO:0140677	molecular function activator activity	13/512	150/18367	0.000298709906819027	0.00502375752377455	ATP1B1/CCL3/APOE/NCF4/ALOX5AP/PSAP/NCF2/DTX3L/GMFG/NCF1/NUPR1/MGST2/CALM2	13
GO:0003823	antigen binding	14/512	171/18367	0.00031954459676656	0.00525473336905009	CD209/HLA-B/HLA-DRA/HLA-A/HLA-DRB1/HLA-C/HLA-DQA1/HLA-DQB1/HLA-DPA1/HLA-E/HLA-DPB1/SIRPA/TGFB1/TSPAN4	14
GO:0015026	coreceptor activity	7/512	48/18367	0.000343333881870551	0.00543117528255488	CD4/CD28/LY96/CD86/NRP1/ENG/LRP1	7
GO:0046332	SMAD binding	9/512	79/18367	0.00034495302470281	0.00543117528255488	DAB2/MEF2A/FOS/TGFBR2/TCF12/DDX5/JUN/CITED2/SKIL	9
GO:0120015	sterol transfer activity	5/512	23/18367	0.000366348696835624	0.00564787574288253	PLTP/APOE/NPC2/ABCA1/TSPO	5
GO:0035591	signaling adaptor activity	9/512	81/18367	0.000416328713981407	0.00628741323155594	DOK2/PAG1/IQGAP1/GNB4/STAT3/ABI1/EPS8/PIK3R1/AKAP13	9
GO:0044389	ubiquitin-like protein ligase binding	20/512	316/18367	0.000593986782911722	0.00879100438709349	LAPTM5/TNFRSF1B/TXNIP/RB1/ARRB2/HSPA1A/LYN/ISG15/PARP9/TNFRSF14/DTX3L/PRKACB/STAT1/HIF1A/RTN4/TMBIM6/STAT2/JUN/PRKAR1A/CCDC50	20
GO:0030246	carbohydrate binding	18/512	271/18367	0.000629412882220889	0.00890501451272489	MRC1/SIGLEC1/ENPP2/CD209/CD93/LGALS9/HLA-DRA/HLA-DRB1/SLC2A3/CD302/CLEC2B/CLEC7A/PYGL/ENG/LGALS1/P4HA1/COLEC12/GAA	18
GO:0005041	low-density lipoprotein particle receptor activity	4/512	15/18367	0.000637791579965431	0.00890501451272489	STAB1/CD36/CXCL16/LRP1	4
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	4/512	15/18367	0.000637791579965431	0.00890501451272489	CYBB/CYBA/NCF2/NCF1	4
GO:0048029	monosaccharide binding	8/512	71/18367	0.000786722410630765	0.0107810108123475	MRC1/CD209/LGALS9/SLC2A3/PYGL/ENG/P4HA1/COLEC12	8
GO:0019207	kinase regulator activity	16/512	233/18367	0.000870953135309928	0.0117182785478063	SPRED1/GAS6/NCKAP1L/IQGAP1/GMFG/KLF4/DAZAP2/TAOK3/ABI1/CCNL1/CAB39/CALM2/PIK3R1/TAOK1/PRKAR1A/STK4	16
GO:0050840	extracellular matrix binding	7/512	56/18367	0.000892941685410662	0.0117995865572123	SPP1/OLFML2B/CTSS/TGFBI/ADAM9/LGALS1/PLEKHA2	7
GO:0046982	protein heterodimerization activity	20/512	328/18367	0.000942346774371497	0.0122339756672791	CYBB/MEF2C/ATP1B1/TLR4/TCF4/CYBA/NR4A2/MEF2A/XBP1/SDCBP/TCF12/NR4A1/MCL1/HIF1A/AHR/USF2/PIK3R1/SNX2/GCA/HEXA	20
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	5/512	29/18367	0.00112653950671558	0.0143730902580954	ADAP2/PLEK/FCHSD2/PLEKHA2/NCF1	5
GO:0030228	lipoprotein particle receptor activity	4/512	18/18367	0.00133793816923128	0.0167809194106975	STAB1/CD36/CXCL16/LRP1	4
GO:0003779	actin binding	24/512	440/18367	0.00144233900721563	0.0176609587783784	MARCKS/AIF1/TMSB4X/MTSS1/MYO5A/CCDC88A/WIPF1/LCP1/IQGAP1/FKBP15/ACTR2/MYO1F/GMFG/CYFIP1/WAS/FXYD5/MSN/TPM3/CAPG/CAPZA2/MYO9B/MACF1/EPS8/GSN	24
GO:0005543	phospholipid binding	25/512	466/18367	0.00145583579119065	0.0176609587783784	PLTP/GAS6/ADAP2/APOE/NCF4/TPP1/MTSS1/PSAP/CCDC88A/ITPR2/ABCA1/PREX1/FCHSD2/IQGAP1/SDCBP/PLA2G15/SNX6/PPT1/WDFY3/NCF1/FCHO2/ZCCHC2/CAPG/SNX2/GSN	25
GO:0004896	cytokine receptor activity	9/512	97/18367	0.00154193786692388	0.0184037745407044	CD4/CMKLR1/CD74/CCR1/IL10RA/IFNGR2/CD44/IL13RA1/IFNAR1	9
GO:0019887	protein kinase regulator activity	14/512	204/18367	0.00180210797456653	0.0211676174790354	SPRED1/GAS6/NCKAP1L/IQGAP1/GMFG/DAZAP2/TAOK3/ABI1/CCNL1/CAB39/CALM2/TAOK1/PRKAR1A/STK4	14
GO:0030295	protein kinase activator activity	9/512	101/18367	0.00204373752318966	0.0236307151118805	GAS6/NCKAP1L/IQGAP1/DAZAP2/ABI1/CAB39/CALM2/TAOK1/STK4	9
GO:0005031	tumor necrosis factor-activated receptor activity	3/512	10/18367	0.00223256251983557	0.0246581532041541	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0008239	dipeptidyl-peptidase activity	3/512	10/18367	0.00223256251983557	0.0246581532041541	CTSC/PRCP/DPP7	3
GO:0016176	superoxide-generating NADPH oxidase activator activity	3/512	10/18367	0.00223256251983557	0.0246581532041541	NCF4/NCF2/NCF1	3
GO:0043539	protein serine/threonine kinase activator activity	6/512	49/18367	0.00230588128903303	0.0250934140277124	IQGAP1/DAZAP2/CAB39/CALM2/TAOK1/STK4	6
GO:0043548	phosphatidylinositol 3-kinase binding	5/512	34/18367	0.00235440190523356	0.0252501073894613	PIK3AP1/HCST/JAK2/PIK3R1/GSN	5
GO:0008199	ferric iron binding	3/512	11/18367	0.0030065812918228	0.0308933667549761	FTL/FTH1/ACP5	3
GO:0019209	kinase activator activity	9/512	107/18367	0.00303202679657362	0.0308933667549761	GAS6/NCKAP1L/IQGAP1/DAZAP2/ABI1/CAB39/CALM2/TAOK1/STK4	9
GO:0015248	sterol transporter activity	5/512	36/18367	0.00304758888258548	0.0308933667549761	PLTP/APOE/NPC2/ABCA1/TSPO	5
GO:0097718	disordered domain specific binding	5/512	36/18367	0.00304758888258548	0.0308933667549761	RB1/HSPA1A/CLTC/AP2A2/CALM2	5
GO:0005158	insulin receptor binding	4/512	23/18367	0.00346768887459776	0.0346768887459776	IGF1/CCDC88A/PIK3R1/SNX2	4
GO:0017154	semaphorin receptor activity	3/512	12/18367	0.00392637163140428	0.038230460621568	PLXND1/NRP1/PLXNB2	3
GO:0097677	STAT family protein binding	3/512	12/18367	0.00392637163140428	0.038230460621568	SPI1/PARP9/DTX3L	3
GO:0002020	protease binding	10/512	135/18367	0.0045793647290813	0.0438267944506162	A2M/CD28/PSAP/TIMP2/CST3/PRNP/CLTC/PYCARD/TIMP1/LRP1	10
GO:0005160	transforming growth factor beta receptor binding	4/512	25/18367	0.00474093832110505	0.0438267944506162	TGFBR2/ENG/SNX6/TGFB1	4
GO:0030247	polysaccharide binding	4/512	25/18367	0.00474093832110505	0.0438267944506162	ENPP2/HLA-DRA/HLA-DRB1/CLEC7A	4
GO:0035035	histone acetyltransferase binding	4/512	25/18367	0.00474093832110505	0.0438267944506162	MEF2A/EGR1/STAT1/CITED2	4
GO:0042169	SH2 domain binding	5/512	40/18367	0.00485648262831152	0.0438267944506162	CCDC88A/SYK/PAG1/JAK2/PTPN6	5
GO:0042287	MHC protein binding	5/512	40/18367	0.00485648262831152	0.0438267944506162	CD4/CD74/HLA-E/CLEC7A/CD81	5
GO:0005035	death receptor activity	3/512	13/18367	0.00499951214244787	0.0440433212548979	TNFRSF1B/TNFRSF14/TNFRSF1A	3
GO:0008035	high-density lipoprotein particle binding	3/512	13/18367	0.00499951214244787	0.0440433212548979	PLTP/CD36/ABCA1	3
GO:0004180	carboxypeptidase activity	5/512	43/18367	0.00663690233687052	0.0577800909327551	CTSZ/LAP3/CPM/PEPD/PRCP	5
GO:0016922	nuclear receptor binding	10/512	144/18367	0.00716251881642775	0.0604231760232308	NR4A2/NRIP1/NR4A1/STAT1/JMJD1C/STAT3/HIF1A/ETS2/DDX5/TACC1	10
GO:0043236	laminin binding	4/512	28/18367	0.00718545877033015	0.0604231760232308	CTSS/ADAM9/LGALS1/PLEKHA2	4
GO:0051861	glycolipid binding	4/512	28/18367	0.00718545877033015	0.0604231760232308	TPP1/PSAP/LYN/PPT1	4
GO:0001784	phosphotyrosine residue binding	5/512	44/18367	0.00732001895479816	0.0608630789500072	SAMSN1/SYK/SH3BP2/PTPN6/PIK3R1	5
GO:0051015	actin filament binding	13/512	217/18367	0.00804902609867604	0.0661771457601412	MARCKS/AIF1/MYO5A/LCP1/IQGAP1/ACTR2/MYO1F/CYFIP1/TPM3/CAPG/CAPZA2/MACF1/GSN	13
GO:0008238	exopeptidase activity	8/512	103/18367	0.00813800035699034	0.0661771457601412	CTSZ/CTSC/TPP1/LAP3/CPM/PEPD/PRCP/DPP7	8
GO:0005521	lamin binding	3/512	16/18367	0.00920042327007782	0.0732076690307268	IFI27/PRNP/BNIP3L	3
GO:0008191	metalloendopeptidase inhibitor activity	3/512	16/18367	0.00920042327007782	0.0732076690307268	BST2/TIMP2/TIMP1	3
GO:0035091	phosphatidylinositol binding	15/512	271/18367	0.00932265510151862	0.0733911146289764	ADAP2/NCF4/CCDC88A/ITPR2/FCHSD2/IQGAP1/SDCBP/SNX6/WDFY3/NCF1/FCHO2/ZCCHC2/CAPG/SNX2/GSN	15
GO:0031625	ubiquitin protein ligase binding	16/512	297/18367	0.00945012868674953	0.0736115287178384	LAPTM5/TNFRSF1B/TXNIP/RB1/ARRB2/HSPA1A/LYN/ISG15/TNFRSF14/PRKACB/HIF1A/RTN4/TMBIM6/JUN/PRKAR1A/CCDC50	16
GO:0048020	CCR chemokine receptor binding	5/512	48/18367	0.010543216417662	0.0804327850419572	CCL2/CCL3/CCL4/STAT1/STAT3	5
GO:0120013	lipid transfer activity	5/512	48/18367	0.010543216417662	0.0804327850419572	PLTP/APOE/NPC2/ABCA1/TSPO	5
GO:0097110	scaffold protein binding	6/512	67/18367	0.010827560370416	0.080985364876239	CD163/PSAP/ITPR2/SYK/LYN/VIM	6
GO:0043395	heparan sulfate proteoglycan binding	3/512	17/18367	0.0109439682265188	0.080985364876239	APOE/PTPRC/LRP1	3
GO:0046965	retinoid X receptor binding	3/512	17/18367	0.0109439682265188	0.080985364876239	NR4A2/NRIP1/TACC1	3
GO:0051219	phosphoprotein binding	7/512	88/18367	0.011443332211332	0.0838422360038187	SAMSN1/RB1/SYK/SH3BP2/LYN/PTPN6/PIK3R1	7
GO:0001530	lipopolysaccharide binding	4/512	33/18367	0.0128763705999661	0.0934168063134794	CD14/LY96/TLR4/NINJ1	4
GO:0031267	small GTPase binding	14/512	259/18367	0.0142270536639833	0.102213783605317	MYO5A/ABCA1/IQGAP1/DMXL2/NCF2/CYFIP1/WAS/ARHGDIB/MYO9B/GOLGA4/EPS8/ATP6AP1/RANBP2/AKAP13	14
GO:0035615	clathrin adaptor activity	3/512	19/18367	0.0149665751126807	0.105439009446391	DAB2/AP1S2/AP2A2	3
GO:0030276	clathrin binding	6/512	72/18367	0.015103425677456	0.105439009446391	DAB2/AP1S2/CLTC/AP2A2/AP1B1/LRP1	6
GO:0042379	chemokine receptor binding	6/512	72/18367	0.015103425677456	0.105439009446391	CCL2/CCL3/CCL4/CXCL16/STAT1/STAT3	6
GO:0003714	transcription corepressor activity	11/512	187/18367	0.0159975040882883	0.110636944161994	RB1/CREG1/HSPA1A/PARP14/PARP9/TRIM22/BTG2/NRIP1/N4BP2L2/ATF7IP/CITED2	11
GO:0051020	GTPase binding	15/512	291/18367	0.0169238943643785	0.115960016941112	MYO5A/ABCA1/LCP1/IQGAP1/DMXL2/NCF2/CYFIP1/WAS/ARHGDIB/MYO9B/GOLGA4/EPS8/ATP6AP1/RANBP2/AKAP13	15
GO:0140312	cargo adaptor activity	3/512	20/18367	0.0172500453863223	0.116987842269055	DAB2/AP1S2/AP2A2	3
GO:0019838	growth factor binding	9/512	141/18367	0.0173900846616162	0.116987842269055	A2M/IGFBP4/CD36/IL10RA/NRP1/DUSP1/TGFBR2/SDCBP/ENG	9
GO:0045309	protein phosphorylated amino acid binding	5/512	56/18367	0.0196446578633291	0.130964385755527	SAMSN1/SYK/SH3BP2/PTPN6/PIK3R1	5
GO:0004602	glutathione peroxidase activity	3/512	22/18367	0.0223676644142119	0.146478510323157	ALOX5AP/GPX1/MGST2	3
GO:0005540	hyaluronic acid binding	3/512	22/18367	0.0223676644142119	0.146478510323157	LYVE1/STAB1/CD44	3
GO:0005085	guanyl-nucleotide exchange factor activity	12/512	223/18367	0.0228936110694558	0.148607650801731	CYTH4/RGL1/DENND3/RIN2/ITSN1/CCDC88A/PREX1/ITSN2/CYTH1/RASGEF1B/GNA13/AKAP13	12
GO:0070412	R-SMAD binding	3/512	23/18367	0.025202660745154	0.162173643055773	FOS/DDX5/JUN	3
GO:1990782	protein tyrosine kinase binding	7/512	105/18367	0.0275550824047725	0.175782422237342	CD4/GAS6/DOK2/SIRPA/DAZAP2/DUSP3/PIK3R1	7
GO:0001965	G-protein alpha-subunit binding	3/512	24/18367	0.0282215008743622	0.176982293618882	RGS1/CCDC88A/RGS10	3
GO:0050431	transforming growth factor beta binding	3/512	24/18367	0.0282215008743622	0.176982293618882	CD36/TGFBR2/ENG	3
GO:0005319	lipid transporter activity	9/512	154/18367	0.0288096248416612	0.179152288931339	PLTP/SLCO2B1/ATP8B4/APOE/CD36/NPC2/ABCA1/PLSCR1/TSPO	9
GO:0004690	cyclic nucleotide-dependent protein kinase activity	2/512	10/18367	0.030092685259776	0.179585379776083	PRKACB/AKAP13	2
GO:0016595	glutamate binding	2/512	10/18367	0.030092685259776	0.179585379776083	GLUL/SLC1A3	2
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/512	10/18367	0.030092685259776	0.179585379776083	PIK3AP1/PIK3R1	2
GO:0043208	glycosphingolipid binding	2/512	10/18367	0.030092685259776	0.179585379776083	PSAP/LYN	2
GO:0070008	serine-type exopeptidase activity	2/512	10/18367	0.030092685259776	0.179585379776083	TPP1/PRCP	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/512	25/18367	0.0314233957679882	0.184550102129455	ZFP36L1/ZFP36/ZFP36L2	3
GO:0051019	mitogen-activated protein kinase binding	3/512	25/18367	0.0314233957679882	0.184550102129455	ARRB2/IQGAP1/DUSP1	3
GO:0044325	transmembrane transporter binding	8/512	133/18367	0.0328883450432558	0.19057902161397	ITPR2/PRNP/SLC8A1/LYN/PYCARD/TSPO/CALM2/HERPUD1	8
GO:0016209	antioxidant activity	6/512	86/18367	0.0329650199548488	0.19057902161397	APOE/ALOX5AP/SOD2/GPX1/MGST2/SESN1	6
GO:0047485	protein N-terminus binding	7/512	110/18367	0.0342936330420869	0.192575821108054	ALOX5AP/RBPJ/HSPA1A/ATM/SDCBP/DCTN4/CALM2	7
GO:0030145	manganese ion binding	5/512	65/18367	0.0347412017512009	0.192575821108054	LAP3/SOD2/GLUL/PEPD/MGAT1	5
GO:0004364	glutathione transferase activity	3/512	26/18367	0.0348071356070622	0.192575821108054	HPGDS/ALOX5AP/MGST2	3
GO:0008198	ferrous iron binding	3/512	26/18367	0.0348071356070622	0.192575821108054	FTL/FTH1/ACP5	3
GO:0042974	retinoic acid receptor binding	3/512	26/18367	0.0348071356070622	0.192575821108054	NR4A2/NRIP1/TACC1	3
GO:0005078	MAP-kinase scaffold activity	2/512	11/18367	0.0361118194748767	0.192575821108054	IQGAP1/AKAP13	2
GO:0005536	glucose binding	2/512	11/18367	0.0361118194748767	0.192575821108054	SLC2A3/PYGL	2
GO:0043560	insulin receptor substrate binding	2/512	11/18367	0.0361118194748767	0.192575821108054	JAK2/PIK3R1	2
GO:1990459	transferrin receptor binding	2/512	11/18367	0.0361118194748767	0.192575821108054	CD81/SNX2	2
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/512	45/18367	0.0361730258567832	0.192575821108054	PEAK1/SYK/LYN/JAK2	4
GO:0048156	tau protein binding	4/512	45/18367	0.0361730258567832	0.192575821108054	LGMN/APOE/ACTB/TAOK1	4
GO:0001664	G protein-coupled receptor binding	14/512	295/18367	0.03773901503184	0.199477650882583	CCL2/CCL3/CCL4/CXCL16/ARRB2/HSPA1A/PRNP/FPR1/JAK2/SDCBP/STAT1/STAT3/GNAI2/GNA13	14
GO:0043178	alcohol binding	6/512	89/18367	0.0380503900191151	0.199697082369824	ADAP2/NPC2/ITPR2/ABCA1/CD81/TSPO	6
GO:0022884	macromolecule transmembrane transporter activity	3/512	27/18367	0.0383711226421874	0.199962188417033	ABCA1/SLC15A3/MCL1	3
GO:0003953	NAD+ nucleosidase activity	3/512	28/18367	0.0421134023068103	0.214191787022059	TLR4/TLR7/PIK3AP1	3
GO:0070325	lipoprotein particle receptor binding	3/512	28/18367	0.0421134023068103	0.214191787022059	APOE/CLTC/LRP1	3
GO:0005024	transforming growth factor beta-activated receptor activity	2/512	12/18367	0.0425489090435712	0.214191787022059	TGFBR2/ENG	2
GO:0043422	protein kinase B binding	2/512	12/18367	0.0425489090435712	0.214191787022059	CCDC88A/ARRB2	2
GO:0046790	virion binding	2/512	12/18367	0.0425489090435712	0.214191787022059	SIGLEC1/CD209	2
GO:0005518	collagen binding	5/512	69/18367	0.0432501829348635	0.216250914674317	CTSS/CTSB/TGFBI/ADAM9/CD44	5
GO:0070851	growth factor receptor binding	8/512	141/18367	0.0440168174648091	0.218539401846521	PDGFC/CCDC88A/LYN/JAK2/PYCARD/SDCBP/PLSCR1/SNX2	8
GO:0070888	E-box binding	4/512	48/18367	0.0442985274013218	0.218539401846521	TCF4/TCF12/HIF1A/AHR	4
GO:0046625	sphingolipid binding	3/512	29/18367	0.0460316926669221	0.225585778632598	PLTP/PSAP/LYN	3
GO:0008009	chemokine activity	4/512	49/18367	0.0472157940834186	0.228363971383855	CCL2/CCL3/CCL4/CXCL16	4
GO:0016763	pentosyltransferase activity	4/512	49/18367	0.0472157940834186	0.228363971383855	TYMP/PARP14/PARP9/NAMPT	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	8/512	144/18367	0.048759678504818	0.233963262618985	TLR4/TLR7/MAN1A1/PIK3AP1/ACER3/FUCA1/GAA/HEXA	8
GO:0004197	cysteine-type endopeptidase activity	7/512	119/18367	0.0490058185215442	0.233963262618985	LGMN/CTSS/CTSB/CTSZ/CTSC/CTSD/PYCARD	7
GO:0015485	cholesterol binding	4/512	50/18367	0.0502371385685283	0.238304375260968	NPC2/ABCA1/CD81/TSPO	4
GO:0000146	microfilament motor activity	3/512	31/18367	0.054385706548115	0.256340272901944	MYO5A/MYO1F/MYO9B	3
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/512	14/18367	0.0565666512470922	0.260105273796449	DOK2/PIK3R1	2
GO:0071837	HMG box domain binding	2/512	14/18367	0.0565666512470922	0.260105273796449	TCF12/JUN	2
GO:0004879	nuclear receptor activity	4/512	52/18367	0.0565904717313897	0.260105273796449	NR4A2/NR4A1/STAT3/AHR	4
GO:0098531	ligand-activated transcription factor activity	4/512	52/18367	0.0565904717313897	0.260105273796449	NR4A2/NR4A1/STAT3/AHR	4
GO:0005539	glycosaminoglycan binding	11/512	230/18367	0.0581543296780264	0.263778483149681	LYVE1/STAB1/APOE/GPNMB/PTPRC/PRNP/NRP1/TGFBR2/ENG/CD44/GNS	11
GO:0061134	peptidase regulator activity	11/512	230/18367	0.0581543296780264	0.263778483149681	A2M/GAS6/NAIP/BST2/CTSC/TIMP2/CST3/SERPING1/PRNP/PYCARD/TIMP1	11
GO:0031406	carboxylic acid binding	9/512	176/18367	0.0585512748673351	0.263778483149681	FOLR2/ALOX5AP/PSAP/PYGL/GLUL/ST8SIA4/P4HA1/SESN1/SLC1A3	9
GO:0071889	14-3-3 protein binding	3/512	32/18367	0.0588154725941856	0.263778483149681	ZFP36L1/ZFP36/ARRB2	3
GO:0005154	epidermal growth factor receptor binding	3/512	33/18367	0.0634093827936075	0.277370898183231	CCDC88A/PLSCR1/SNX2	3
GO:0019956	chemokine binding	3/512	33/18367	0.0634093827936075	0.277370898183231	A2M/CCR1/ZFP36	3
GO:0005161	platelet-derived growth factor receptor binding	2/512	15/18367	0.0640951670126116	0.277370898183231	PDGFC/LYN	2
GO:0016846	carbon-sulfur lyase activity	2/512	15/18367	0.0640951670126116	0.277370898183231	ALOX5AP/MGST2	2
GO:0048185	activin binding	2/512	15/18367	0.0640951670126116	0.277370898183231	TGFBR2/ENG	2
GO:0050998	nitric-oxide synthase binding	2/512	15/18367	0.0640951670126116	0.277370898183231	CD74/ACTB	2
GO:0042826	histone deacetylase binding	7/512	127/18367	0.0650094469454093	0.278074210638005	MEF2C/SPI1/HSPA1A/MEF2A/KLF4/NRIP1/HIF1A	7
GO:0004866	endopeptidase inhibitor activity	9/512	180/18367	0.0655206959600162	0.278074210638005	A2M/GAS6/NAIP/BST2/TIMP2/CST3/SERPING1/PRNP/TIMP1	9
GO:0005125	cytokine activity	11/512	235/18367	0.0656725803001383	0.278074210638005	SPP1/CCL2/CCL3/CCL4/CXCL16/GRN/NAMPT/TNFSF13B/TGFB1/CMTM3/TIMP1	11
GO:0001221	transcription coregulator binding	5/512	78/18367	0.0666003553965199	0.278074210638005	FOXO3/KLF4/STAT1/HIF1A/AHR	5
GO:0030971	receptor tyrosine kinase binding	5/512	78/18367	0.0666003553965199	0.278074210638005	GAS6/DOK2/DAZAP2/DUSP3/PIK3R1	5
GO:0005080	protein kinase C binding	4/512	55/18367	0.0668881209372498	0.278074210638005	MARCKS/PLEK/CCDC88A/ADAM9	4
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	4/512	55/18367	0.0668881209372498	0.278074210638005	ALOX5AP/GPX1/MGST2/SESN1	4
GO:0005200	structural constituent of cytoskeleton	6/512	103/18367	0.0681741898055261	0.281837432715583	HLA-DRB1/TUBA1A/ACTB/VIM/ACTR2/MSN	6
GO:0031072	heat shock protein binding	7/512	129/18367	0.0694508237794256	0.285520053315416	ITGB2/ITGAM/FKBP5/ZFP36/HSPA1A/HIF1A/AHR	7
GO:0005092	GDP-dissociation inhibitor activity	2/512	16/18367	0.071937273261545	0.28774909304618	CCDC88A/ARHGDIB	2
GO:0005159	insulin-like growth factor receptor binding	2/512	16/18367	0.071937273261545	0.28774909304618	IGF1/PIK3R1	2
GO:0035497	cAMP response element binding	2/512	16/18367	0.071937273261545	0.28774909304618	TCF12/JUN	2
GO:0070492	oligosaccharide binding	2/512	16/18367	0.071937273261545	0.28774909304618	LGALS9/LGALS1	2
GO:1990404	protein ADP-ribosylase activity	2/512	16/18367	0.071937273261545	0.28774909304618	PARP14/PARP9	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	4/512	58/18367	0.0780868850773911	0.303854299027346	HPGDS/ALOX5AP/MGST2/MAT2A	4
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	5/512	82/18367	0.078844251555851	0.303854299027346	ADAP2/SDCBP/FCHO2/CAPG/GSN	5
GO:0030414	peptidase inhibitor activity	9/512	187/18367	0.0789292982426266	0.303854299027346	A2M/GAS6/NAIP/BST2/TIMP2/CST3/SERPING1/PRNP/TIMP1	9
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/512	17/18367	0.0800697139328818	0.303854299027346	PTPRC/PTPN6	2
GO:0008525	phosphatidylcholine transporter activity	2/512	17/18367	0.0800697139328818	0.303854299027346	PLTP/ABCA1	2
GO:0015278	calcium-release channel activity	2/512	17/18367	0.0800697139328818	0.303854299027346	MCOLN1/ITPR2	2
GO:0017081	chloride channel regulator activity	2/512	17/18367	0.0800697139328818	0.303854299027346	SGK1/STX7	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/512	17/18367	0.0800697139328818	0.303854299027346	PTPRC/PTPN6	2
GO:0034185	apolipoprotein binding	2/512	17/18367	0.0800697139328818	0.303854299027346	ABCA1/LRP1	2
GO:0050780	dopamine receptor binding	2/512	17/18367	0.0800697139328818	0.303854299027346	ARRB2/GNA13	2
GO:0032934	sterol binding	4/512	60/18367	0.0860389737308015	0.324841023269353	NPC2/ABCA1/CD81/TSPO	4
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/512	18/18367	0.0884702813947449	0.32823287940548	TGFBR2/DAZAP2	2
GO:0033549	MAP kinase phosphatase activity	2/512	18/18367	0.0884702813947449	0.32823287940548	DUSP1/DUSP3	2
GO:0046624	sphingolipid transporter activity	2/512	18/18367	0.0884702813947449	0.32823287940548	PLTP/ABCA1	2
GO:0140303	intramembrane lipid transporter activity	3/512	38/18367	0.0887115890285081	0.32823287940548	ATP8B4/ABCA1/PLSCR1	3
GO:0061135	endopeptidase regulator activity	9/512	194/18367	0.0938913872028627	0.344001486187123	A2M/GAS6/NAIP/BST2/TIMP2/CST3/SERPING1/PRNP/TIMP1	9
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	3/512	39/18367	0.0942105402935053	0.344001486187123	ADAP2/FCHSD2/IQGAP1	3
GO:1990841	promoter-specific chromatin binding	4/512	62/18367	0.0943679752648458	0.344001486187123	EGR1/KLF4/STAT1/DDX5	4
GO:0000339	RNA cap binding	2/512	19/18367	0.0971177762514584	0.350571485005264	EIF4G3/CYFIP1	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/512	19/18367	0.0971177762514584	0.350571485005264	TGFBR2/ENG	2
GO:0016829	lyase activity	9/512	196/18367	0.0984510158584128	0.353658989005949	RNASE1/ALOX5AP/RSAD2/TBXAS1/RNASET2/ADCY7/MGST2/NPL/ME2	9
GO:0004177	aminopeptidase activity	3/512	40/18367	0.0998457619762478	0.355220499338574	LAP3/PEPD/DPP7	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/512	40/18367	0.0998457619762478	0.355220499338574	GAS6/NAIP/PYCARD	3
GO:0019199	transmembrane receptor protein kinase activity	7/512	143/18367	0.105470334309632	0.359789251108519	CSF1R/SYK/NRP1/LYN/JAK2/TGFBR2/ENG	7
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/512	20/18367	0.105991968569807	0.359789251108519	FOS/STAT1	2
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/512	20/18367	0.105991968569807	0.359789251108519	TCF4/AHR	2
GO:0016505	peptidase activator activity involved in apoptotic process	2/512	20/18367	0.105991968569807	0.359789251108519	CTSC/PYCARD	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/512	20/18367	0.105991968569807	0.359789251108519	SGMS1/CEPT1	2
GO:0030296	protein tyrosine kinase activator activity	2/512	20/18367	0.105991968569807	0.359789251108519	GAS6/ABI1	2
GO:0030506	ankyrin binding	2/512	20/18367	0.105991968569807	0.359789251108519	PTPRC/SLC8A1	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/512	20/18367	0.105991968569807	0.359789251108519	GNAI2/GNA13	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/512	20/18367	0.105991968569807	0.359789251108519	KLF4/PIK3R1	2
GO:0097001	ceramide binding	2/512	20/18367	0.105991968569807	0.359789251108519	PLTP/PSAP	2
GO:0005516	calmodulin binding	9/512	201/18367	0.110398587582828	0.373036323339237	MARCKS/MYO5A/MKNK1/RGS1/SLC8A1/IQGAP1/MYO1F/DDX5/MYO9B	9
GO:1901981	phosphatidylinositol phosphate binding	8/512	173/18367	0.111508848709277	0.375075218385749	ADAP2/NCF4/FCHSD2/IQGAP1/SDCBP/FCHO2/CAPG/GSN	8
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	5/512	94/18367	0.122144080429144	0.407144562219001	MAN1A1/ACER3/FUCA1/GAA/HEXA	5
GO:0004674	protein serine/threonine kinase activity	15/512	386/18367	0.123614796933915	0.407144562219001	CCL3/BMP2K/MKNK1/SYK/MAP3K8/ATM/TGFBR2/ENG/SGK1/PRKACB/TAOK3/MAP3K1/TAOK1/STK4/AKAP13	15
GO:0008375	acetylglucosaminyltransferase activity	3/512	44/18367	0.123659934832525	0.407144562219001	MGAT4A/MGAT1/HEXA	3
GO:0005537	mannose binding	2/512	22/18367	0.1243441500831	0.407144562219001	MRC1/CD209	2
GO:0008320	protein transmembrane transporter activity	2/512	22/18367	0.1243441500831	0.407144562219001	ABCA1/MCL1	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/512	22/18367	0.1243441500831	0.407144562219001	GAS6/NAIP	2
GO:0004857	enzyme inhibitor activity	4/512	70/18367	0.131202897712797	0.423084553624652	TXNIP/PARP9/DTX3L/TMBIM6	4
GO:0004860	protein kinase inhibitor activity	4/512	70/18367	0.131202897712797	0.423084553624652	SPRED1/GMFG/TAOK3/PRKAR1A	4
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/512	23/18367	0.133786196686714	0.423084553624652	PARP14/PARP9	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/512	23/18367	0.133786196686714	0.423084553624652	CCL3/MKNK1	2
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	2/512	23/18367	0.133786196686714	0.423084553624652	ALOX5AP/ALOX5	2
GO:0016849	phosphorus-oxygen lyase activity	2/512	23/18367	0.133786196686714	0.423084553624652	RNASET2/ADCY7	2
GO:0050750	low-density lipoprotein particle receptor binding	2/512	23/18367	0.133786196686714	0.423084553624652	APOE/CLTC	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/512	23/18367	0.133786196686714	0.423084553624652	MGAT4A/MGAT1	2
GO:0048018	receptor ligand activity	18/512	487/18367	0.137826684391696	0.434007431701511	SPP1/CCL2/IGF1/GAS6/CCL3/PDGFC/GPNMB/CCL4/METRNL/CXCL16/TYMP/GRN/NAMPT/TNFSF13B/GMFG/TGFB1/CMTM3/TIMP1	18
GO:0009055	electron transfer activity	6/512	126/18367	0.140517647326644	0.436639549543956	CYBB/CYBA/NCF2/NCF1/DHRS3/ME2	6
GO:0003712	transcription coregulator activity	18/512	489/18367	0.141451284232751	0.436639549543956	RB1/CREG1/HSPA1A/MTDH/PARP14/PARP9/TRIM22/BTG2/NRIP1/N4BP2L2/NUPR1/NCOA4/JMJD1C/DDX17/TACC1/ATF7IP/TRIM38/CITED2	18
GO:0004622	lysophospholipase activity	2/512	24/18367	0.14338298721511	0.436639549543956	ENPP2/PLA2G15	2
GO:0010857	calcium-dependent protein kinase activity	2/512	24/18367	0.14338298721511	0.436639549543956	CCL3/MKNK1	2
GO:0015295	solute:proton symporter activity	2/512	24/18367	0.14338298721511	0.436639549543956	SLC15A3/SLC11A2	2
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	2/512	24/18367	0.14338298721511	0.436639549543956	ALOX5AP/ALOX5	2
GO:0019957	C-C chemokine binding	2/512	24/18367	0.14338298721511	0.436639549543956	CCR1/ZFP36	2
GO:0043274	phospholipase binding	2/512	24/18367	0.14338298721511	0.436639549543956	SYK/WAS	2
GO:0003924	GTPase activity	13/512	337/18367	0.149721367711068	0.454073000435207	RGS1/MX2/MX1/TUBA1A/RAP2B/RGS10/GIMAP7/ARHGDIB/ARL4C/GNAI2/RHOB/GNA13/RAB8B	13
GO:0019210	kinase inhibitor activity	4/512	74/18367	0.151531148740884	0.457685918645936	SPRED1/GMFG/TAOK3/PRKAR1A	4
GO:0030546	signaling receptor activator activity	18/512	495/18367	0.152646386461412	0.459180186916443	SPP1/CCL2/IGF1/GAS6/CCL3/PDGFC/GPNMB/CCL4/METRNL/CXCL16/TYMP/GRN/NAMPT/TNFSF13B/GMFG/TGFB1/CMTM3/TIMP1	18
GO:0032813	tumor necrosis factor receptor superfamily binding	3/512	49/18367	0.155948580484675	0.467214370682831	TNFSF13B/STAT1/FEM1B	3
GO:0008234	cysteine-type peptidase activity	8/512	190/18367	0.16224095806619	0.476694232150794	LGMN/CTSS/CTSB/CTSZ/CTSC/CTSD/OTUD1/PYCARD	8
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	3/512	50/18367	0.162696119330386	0.476694232150794	TLR4/TLR7/PIK3AP1	3
GO:0030159	signaling receptor complex adaptor activity	3/512	50/18367	0.162696119330386	0.476694232150794	DOK2/GNB4/PIK3R1	3
GO:0001637	G protein-coupled chemoattractant receptor activity	2/512	26/18367	0.162977892883988	0.476694232150794	CMKLR1/CCR1	2
GO:0004950	chemokine receptor activity	2/512	26/18367	0.162977892883988	0.476694232150794	CMKLR1/CCR1	2
GO:0099604	ligand-gated calcium channel activity	2/512	26/18367	0.162977892883988	0.476694232150794	MCOLN1/ITPR2	2
GO:0008083	growth factor activity	7/512	162/18367	0.167403112672433	0.486106824147349	IGF1/PDGFC/TYMP/GRN/GMFG/TGFB1/TIMP1	7
GO:0003724	RNA helicase activity	4/512	77/18367	0.167509783996722	0.486106824147349	DDX60L/IFIH1/DDX17/DDX5	4
GO:0004601	peroxidase activity	3/512	51/18367	0.169529489728811	0.486617344229906	ALOX5AP/GPX1/MGST2	3
GO:0016860	intramolecular oxidoreductase activity	3/512	51/18367	0.169529489728811	0.486617344229906	HPGDS/TBXAS1/GNPDA1	3
GO:0005525	GTP binding	14/512	377/18367	0.170270496119244	0.486617344229906	IFI44L/MX2/MX1/SAMHD1/GIMAP4/TUBA1A/RAP2B/EHD4/GIMAP7/ARL4C/GNAI2/RHOB/GNA13/RAB8B	14
GO:0004709	MAP kinase kinase kinase activity	2/512	27/18367	0.172946434503332	0.486617344229906	MAP3K8/MAP3K1	2
GO:0015491	cation:cation antiporter activity	2/512	27/18367	0.172946434503332	0.486617344229906	SLC9A9/SLC8A1	2
GO:0043425	bHLH transcription factor binding	2/512	27/18367	0.172946434503332	0.486617344229906	TCF12/USF2	2
GO:0070006	metalloaminopeptidase activity	2/512	27/18367	0.172946434503332	0.486617344229906	LAP3/PEPD	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/512	27/18367	0.172946434503332	0.486617344229906	ATP8B4/ABCA1	2
GO:0008186	ATP-dependent activity, acting on RNA	4/512	79/18367	0.178479526292288	0.499573939660113	DDX60L/IFIH1/DDX17/DDX5	4
GO:1902936	phosphatidylinositol bisphosphate binding	5/512	107/18367	0.178901478391797	0.499573939660113	ADAP2/SDCBP/FCHO2/CAPG/GSN	5
GO:0004713	protein tyrosine kinase activity	6/512	136/18367	0.17991370764568	0.499733506598773	CSF1R/PEAK1/SYK/NRP1/LYN/JAK2	6
GO:0019902	phosphatase binding	8/512	196/18367	0.182347799070867	0.499733506598773	SPRED1/CTSC/SYK/SIRPA/IQGAP1/STAT1/STAT3/PIK3R1	8
GO:0001968	fibronectin binding	2/512	28/18367	0.183010513903064	0.499733506598773	CTSS/PLEKHA2	2
GO:0003785	actin monomer binding	2/512	28/18367	0.183010513903064	0.499733506598773	TMSB4X/MTSS1	2
GO:0046875	ephrin receptor binding	2/512	28/18367	0.183010513903064	0.499733506598773	LYN/SDCBP	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/512	28/18367	0.183010513903064	0.499733506598773	FEM1B/HERPUD1	2
GO:0004181	metallocarboxypeptidase activity	2/512	29/18367	0.19315709325389	0.523576003691862	CPM/PEPD	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/512	29/18367	0.19315709325389	0.523576003691862	TBXAS1/BLVRB	2
GO:0005217	intracellular ligand-gated ion channel activity	2/512	30/18367	0.203373784751889	0.545277538827529	MCOLN1/ITPR2	2
GO:0046966	thyroid hormone receptor binding	2/512	30/18367	0.203373784751889	0.545277538827529	JMJD1C/TACC1	2
GO:0070566	adenylyltransferase activity	2/512	30/18367	0.203373784751889	0.545277538827529	OAS2/OAS1	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/512	56/18367	0.204825303315474	0.547186730878884	GAS6/NAIP/CST3	3
GO:0005548	phospholipid transporter activity	3/512	57/18367	0.212079180005218	0.560638759662158	PLTP/ABCA1/PLSCR1	3
GO:0008013	beta-catenin binding	4/512	85/18367	0.212722156324066	0.560638759662158	TCF4/NR4A2/FOXO3/KLF4	4
GO:0005164	tumor necrosis factor receptor binding	2/512	31/18367	0.213648824628012	0.560638759662158	TNFSF13B/STAT1	2
GO:0031210	phosphatidylcholine binding	2/512	31/18367	0.213648824628012	0.560638759662158	PLTP/ABCA1	2
GO:0140318	protein transporter activity	2/512	31/18367	0.213648824628012	0.560638759662158	ABCA1/MCL1	2
GO:0045296	cadherin binding	12/512	332/18367	0.218178398245926	0.569593788290928	HSPA1A/EHD4/EPS15/IQGAP1/ARHGAP18/FXYD5/STAT1/RTN4/CAPG/ABI1/MACF1/SNX2	12
GO:0042562	hormone binding	4/512	86/18367	0.218600859290032	0.569593788290928	CMKLR1/ALDH1A1/TSPO/PIK3R1	4
GO:0016757	glycosyltransferase activity	10/512	270/18367	0.222925273700484	0.573489880940244	MGAT4A/COLGALT1/TYMP/PARP14/PARP9/NAMPT/PYGL/ST8SIA4/MGAT1/HEXA	10
GO:0019001	guanyl nucleotide binding	14/512	398/18367	0.222974074080753	0.573489880940244	IFI44L/MX2/MX1/SAMHD1/GIMAP4/TUBA1A/RAP2B/EHD4/GIMAP7/ARL4C/GNAI2/RHOB/GNA13/RAB8B	14
GO:0032561	guanyl ribonucleotide binding	14/512	398/18367	0.222974074080753	0.573489880940244	IFI44L/MX2/MX1/SAMHD1/GIMAP4/TUBA1A/RAP2B/EHD4/GIMAP7/ARL4C/GNAI2/RHOB/GNA13/RAB8B	14
GO:0001223	transcription coactivator binding	2/512	32/18367	0.223971048096933	0.573489880940244	HIF1A/AHR	2
GO:0050699	WW domain binding	2/512	32/18367	0.223971048096933	0.573489880940244	DAZAP2/LITAF	2
GO:0098631	cell adhesion mediator activity	3/512	59/18367	0.226747103660083	0.578596057615385	NINJ1/SIRPA/EMB	3
GO:0016651	oxidoreductase activity, acting on NAD(P)H	4/512	88/18367	0.230485752786488	0.580158181859603	CYBB/CYBA/NCF2/NCF1	4
GO:0019239	deaminase activity	2/512	33/18367	0.234329865213277	0.580158181859603	GNPDA1/ADAR	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/512	34/18367	0.244715237604218	0.580158181859603	SPRED1/PRKAR1A	2
GO:0005506	iron ion binding	6/512	151/18367	0.24596188643785	0.580158181859603	FTL/TBXAS1/ALOX5/FTH1/ACP5/P4HA1	6
GO:0001094	TFIID-class transcription factor complex binding	1/512	10/18367	0.246322131026125	0.580158181859603	AHR	1
GO:0004955	prostaglandin receptor activity	1/512	10/18367	0.246322131026125	0.580158181859603	PTGER4	1
GO:0005384	manganese ion transmembrane transporter activity	1/512	10/18367	0.246322131026125	0.580158181859603	SLC11A2	1
GO:0005432	calcium:sodium antiporter activity	1/512	10/18367	0.246322131026125	0.580158181859603	SLC8A1	1
GO:0005522	profilin binding	1/512	10/18367	0.246322131026125	0.580158181859603	WIPF1	1
GO:0005528	FK506 binding	1/512	10/18367	0.246322131026125	0.580158181859603	FKBP5	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/512	10/18367	0.246322131026125	0.580158181859603	DUSP1	1
GO:0008526	phosphatidylinositol transfer activity	1/512	10/18367	0.246322131026125	0.580158181859603	PLTP	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/512	10/18367	0.246322131026125	0.580158181859603	ATG7	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/512	10/18367	0.246322131026125	0.580158181859603	MAN1A1	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/512	10/18367	0.246322131026125	0.580158181859603	ATM	1
GO:0017002	activin-activated receptor activity	1/512	10/18367	0.246322131026125	0.580158181859603	TGFBR2	1
GO:0019869	chloride channel inhibitor activity	1/512	10/18367	0.246322131026125	0.580158181859603	STX7	1
GO:0030957	Tat protein binding	1/512	10/18367	0.246322131026125	0.580158181859603	ACTB	1
GO:0035612	AP-2 adaptor complex binding	1/512	10/18367	0.246322131026125	0.580158181859603	BMP2K	1
GO:0045503	dynein light chain binding	1/512	10/18367	0.246322131026125	0.580158181859603	GLUL	1
GO:0050786	RAGE receptor binding	1/512	10/18367	0.246322131026125	0.580158181859603	FPR1	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	1/512	10/18367	0.246322131026125	0.580158181859603	PLA2G15	1
GO:0071723	lipopeptide binding	1/512	10/18367	0.246322131026125	0.580158181859603	CD14	1
GO:0120016	sphingolipid transfer activity	1/512	10/18367	0.246322131026125	0.580158181859603	PLTP	1
GO:0015081	sodium ion transmembrane transporter activity	6/512	152/18367	0.250602432606275	0.580158181859603	SCN9A/SLC9A9/ATP1B1/SLC8A1/SLC1A3/SLC4A7	6
GO:0051213	dioxygenase activity	4/512	92/18367	0.254705088265939	0.580158181859603	ALOX5AP/ALOX5/P4HA1/JMJD1C	4
GO:0015298	solute:cation antiporter activity	2/512	35/18367	0.255117656048532	0.580158181859603	SLC9A9/SLC8A1	2
GO:0072341	modified amino acid binding	4/512	93/18367	0.260841128868265	0.580158181859603	FOLR2/GAS6/FCHO2/MGST2	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	5/512	124/18367	0.264559751542819	0.580158181859603	CSF1R/SYK/NRP1/LYN/JAK2	5
GO:0005484	SNAP receptor activity	2/512	36/18367	0.265528118873118	0.580158181859603	STX7/STX12	2
GO:0004016	adenylate cyclase activity	1/512	11/18367	0.267343162181249	0.580158181859603	ADCY7	1
GO:0004954	prostanoid receptor activity	1/512	11/18367	0.267343162181249	0.580158181859603	PTGER4	1
GO:0008503	benzodiazepine receptor activity	1/512	11/18367	0.267343162181249	0.580158181859603	TSPO	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/512	11/18367	0.267343162181249	0.580158181859603	PRKAR1A	1
GO:0015368	calcium:cation antiporter activity	1/512	11/18367	0.267343162181249	0.580158181859603	SLC8A1	1
GO:0015386	potassium:proton antiporter activity	1/512	11/18367	0.267343162181249	0.580158181859603	SLC9A9	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/512	11/18367	0.267343162181249	0.580158181859603	DSE	1
GO:0017128	phospholipid scramblase activity	1/512	11/18367	0.267343162181249	0.580158181859603	PLSCR1	1
GO:0019855	calcium channel inhibitor activity	1/512	11/18367	0.267343162181249	0.580158181859603	CALM2	1
GO:0032052	bile acid binding	1/512	11/18367	0.267343162181249	0.580158181859603	PYGL	1
GO:0035197	siRNA binding	1/512	11/18367	0.267343162181249	0.580158181859603	TLR7	1
GO:0035673	oligopeptide transmembrane transporter activity	1/512	11/18367	0.267343162181249	0.580158181859603	SLC15A3	1
GO:0043295	glutathione binding	1/512	11/18367	0.267343162181249	0.580158181859603	MGST2	1
GO:0051400	BH domain binding	1/512	11/18367	0.267343162181249	0.580158181859603	MCL1	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	1/512	11/18367	0.267343162181249	0.580158181859603	PLA2G15	1
GO:0061665	SUMO ligase activity	1/512	11/18367	0.267343162181249	0.580158181859603	RANBP2	1
GO:0070513	death domain binding	1/512	11/18367	0.267343162181249	0.580158181859603	MCL1	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/512	11/18367	0.267343162181249	0.580158181859603	SIRPA	1
GO:0099186	structural constituent of postsynapse	1/512	11/18367	0.267343162181249	0.580158181859603	ACTB	1
GO:0102545	phosphatidyl phospholipase B activity	1/512	11/18367	0.267343162181249	0.580158181859603	PLA2G15	1
GO:0140036	ubiquitin-dependent protein binding	1/512	11/18367	0.267343162181249	0.580158181859603	LAPTM5	1
GO:0004386	helicase activity	6/512	156/18367	0.269400870238967	0.582914163674957	DDX60L/CHD9/IFIH1/SETX/DDX17/DDX5	6
GO:0016409	palmitoyltransferase activity	2/512	37/18367	0.275938111138974	0.586747362351138	GLUL/SPTLC2	2
GO:0042056	chemoattractant activity	2/512	37/18367	0.275938111138974	0.586747362351138	CCL3/GPNMB	2
GO:0046915	transition metal ion transmembrane transporter activity	2/512	37/18367	0.275938111138974	0.586747362351138	MCOLN1/SLC11A2	2
GO:0016853	isomerase activity	6/512	158/18367	0.278928937479652	0.586747362351138	HPGDS/FKBP5/TBXAS1/FKBP15/DSE/GNPDA1	6
GO:0008236	serine-type peptidase activity	7/512	191/18367	0.284541040633181	0.586747362351138	C2/CFD/CTSS/CTSC/TPP1/PRCP/DPP7	7
GO:0140678	molecular function inhibitor activity	5/512	128/18367	0.285983338255212	0.586747362351138	TXNIP/PARP9/DTX3L/TMBIM6/CALM2	5
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/512	38/18367	0.286339584589556	0.586747362351138	FKBP5/FKBP15	2
GO:0000340	RNA 7-methylguanosine cap binding	1/512	12/18367	0.287779003375584	0.586747362351138	CYFIP1	1
GO:0005095	GTPase inhibitor activity	1/512	12/18367	0.287779003375584	0.586747362351138	IQGAP1	1
GO:0005165	neurotrophin receptor binding	1/512	12/18367	0.287779003375584	0.586747362351138	PIK3R1	1
GO:0005527	macrolide binding	1/512	12/18367	0.287779003375584	0.586747362351138	FKBP5	1
GO:0008429	phosphatidylethanolamine binding	1/512	12/18367	0.287779003375584	0.586747362351138	PLTP	1
GO:0031543	peptidyl-proline dioxygenase activity	1/512	12/18367	0.287779003375584	0.586747362351138	P4HA1	1
GO:0032396	inhibitory MHC class I receptor activity	1/512	12/18367	0.287779003375584	0.586747362351138	LILRB5	1
GO:0033130	acetylcholine receptor binding	1/512	12/18367	0.287779003375584	0.586747362351138	JAK2	1
GO:0034452	dynactin binding	1/512	12/18367	0.287779003375584	0.586747362351138	SNX6	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/512	12/18367	0.287779003375584	0.586747362351138	ATM	1
GO:0035256	G protein-coupled glutamate receptor binding	1/512	12/18367	0.287779003375584	0.586747362351138	PRNP	1
GO:0042975	peroxisome proliferator activated receptor binding	1/512	12/18367	0.287779003375584	0.586747362351138	TACC1	1
GO:1900750	oligopeptide binding	1/512	12/18367	0.287779003375584	0.586747362351138	MGST2	1
GO:0016298	lipase activity	5/512	129/18367	0.291390506607615	0.586747362351138	ENPP2/CCR1/PLD3/LIPA/PLA2G15	5
GO:0050997	quaternary ammonium group binding	2/512	39/18367	0.296724938335288	0.586747362351138	PLTP/ABCA1	2
GO:0015078	proton transmembrane transporter activity	5/512	130/18367	0.296815579867965	0.586747362351138	SLC9A9/SLC15A3/SLC11A2/ATP6V0A1/ATP6V0B	5
GO:0017171	serine hydrolase activity	7/512	195/18367	0.302146099253887	0.586747362351138	C2/CFD/CTSS/CTSC/TPP1/PRCP/DPP7	7
GO:0005496	steroid binding	4/512	100/18367	0.304470313007318	0.586747362351138	NPC2/ABCA1/CD81/TSPO	4
GO:0017080	sodium channel regulator activity	2/512	40/18367	0.307087000248921	0.586747362351138	SGK1/FXYD5	2
GO:0043014	alpha-tubulin binding	2/512	40/18367	0.307087000248921	0.586747362351138	ARL4C/TAOK1	2
GO:0044183	protein folding chaperone	2/512	40/18367	0.307087000248921	0.586747362351138	CD74/HSPA1A	2
GO:0004000	adenosine deaminase activity	1/512	13/18367	0.30764591431384	0.586747362351138	ADAR	1
GO:0005542	folic acid binding	1/512	13/18367	0.30764591431384	0.586747362351138	FOLR2	1
GO:0008179	adenylate cyclase binding	1/512	13/18367	0.30764591431384	0.586747362351138	CALM2	1
GO:0015385	sodium:proton antiporter activity	1/512	13/18367	0.30764591431384	0.586747362351138	SLC9A9	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/512	13/18367	0.30764591431384	0.586747362351138	DUSP1	1
GO:0031386	protein tag	1/512	13/18367	0.30764591431384	0.586747362351138	ISG15	1
GO:0031404	chloride ion binding	1/512	13/18367	0.30764591431384	0.586747362351138	CTSC	1
GO:0031432	titin binding	1/512	13/18367	0.30764591431384	0.586747362351138	CALM2	1
GO:0031994	insulin-like growth factor I binding	1/512	13/18367	0.30764591431384	0.586747362351138	IGFBP4	1
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	1/512	13/18367	0.30764591431384	0.586747362351138	JMJD1C	1
GO:0034236	protein kinase A catalytic subunit binding	1/512	13/18367	0.30764591431384	0.586747362351138	PRKAR1A	1
GO:0045159	myosin II binding	1/512	13/18367	0.30764591431384	0.586747362351138	GSN	1
GO:0051011	microtubule minus-end binding	1/512	13/18367	0.30764591431384	0.586747362351138	MACF1	1
GO:0052650	NADP-retinol dehydrogenase activity	1/512	13/18367	0.30764591431384	0.586747362351138	DHRS3	1
GO:0070679	inositol 1,4,5 trisphosphate binding	1/512	13/18367	0.30764591431384	0.586747362351138	ITPR2	1
GO:0070700	BMP receptor binding	1/512	13/18367	0.30764591431384	0.586747362351138	PYCARD	1
GO:0072542	protein phosphatase activator activity	1/512	13/18367	0.30764591431384	0.586747362351138	CALM2	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/512	13/18367	0.30764591431384	0.586747362351138	LAPTM5	1
GO:0003713	transcription coactivator activity	9/512	262/18367	0.309186838409881	0.588170335278436	MTDH/TRIM22/NRIP1/NUPR1/NCOA4/DDX17/TACC1/TRIM38/CITED2	9
GO:0004725	protein tyrosine phosphatase activity	4/512	102/18367	0.317093243198918	0.595844721882324	PTPRC/DUSP1/PTPN6/DUSP3	4
GO:0016859	cis-trans isomerase activity	2/512	41/18367	0.317419009047217	0.595844721882324	FKBP5/FKBP15	2
GO:0030331	estrogen receptor binding	2/512	41/18367	0.317419009047217	0.595844721882324	NRIP1/TACC1	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/512	71/18367	0.317569758643484	0.595844721882324	ASAH1/GLS/ACER3	3
GO:0031490	chromatin DNA binding	4/512	103/18367	0.323421262896716	0.595844721882324	ACTB/FOXO3/JMJD1C/STAT3	4
GO:0043177	organic acid binding	5/512	135/18367	0.324164730029243	0.595844721882324	FOLR2/ALOX5AP/GLUL/P4HA1/SLC1A3	5
GO:0008235	metalloexopeptidase activity	3/512	72/18367	0.325237111110098	0.595844721882324	LAP3/CPM/PEPD	3
GO:0005172	vascular endothelial growth factor receptor binding	1/512	14/18367	0.326959703780513	0.595844721882324	CCDC88A	1
GO:0005313	L-glutamate transmembrane transporter activity	1/512	14/18367	0.326959703780513	0.595844721882324	SLC1A3	1
GO:0005451	monovalent cation:proton antiporter activity	1/512	14/18367	0.326959703780513	0.595844721882324	SLC9A9	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/512	14/18367	0.326959703780513	0.595844721882324	PPT1	1
GO:0015926	glucosidase activity	1/512	14/18367	0.326959703780513	0.595844721882324	GAA	1
GO:0019992	diacylglycerol binding	1/512	14/18367	0.326959703780513	0.595844721882324	PLTP	1
GO:0036041	long-chain fatty acid binding	1/512	14/18367	0.326959703780513	0.595844721882324	ALOX5AP	1
GO:0044548	S100 protein binding	1/512	14/18367	0.326959703780513	0.595844721882324	IQGAP1	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/512	14/18367	0.326959703780513	0.595844721882324	GPR34	1
GO:0098599	palmitoyl hydrolase activity	1/512	14/18367	0.326959703780513	0.595844721882324	PPT1	1
GO:0001046	core promoter sequence-specific DNA binding	2/512	42/18367	0.327714597035278	0.595844721882324	FOS/STAT1	2
GO:0004620	phospholipase activity	4/512	104/18367	0.329757833597917	0.596627865189385	ENPP2/CCR1/PLD3/PLA2G15	4
GO:0015294	solute:cation symporter activity	4/512	104/18367	0.329757833597917	0.596627865189385	SLC15A3/SLC11A2/SLC1A3/SLC4A7	4
GO:0033293	monocarboxylic acid binding	3/512	73/18367	0.33290411632614	0.597767404601863	ALOX5AP/PSAP/PYGL	3
GO:0005246	calcium channel regulator activity	2/512	43/18367	0.337967773490616	0.597767404601863	SGK1/CALM2	2
GO:0016504	peptidase activator activity	2/512	43/18367	0.337967773490616	0.597767404601863	CTSC/PYCARD	2
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/512	15/18367	0.345735742121078	0.597767404601863	ALDH1A1	1
GO:0004559	alpha-mannosidase activity	1/512	15/18367	0.345735742121078	0.597767404601863	MAN1A1	1
GO:0004953	icosanoid receptor activity	1/512	15/18367	0.345735742121078	0.597767404601863	PTGER4	1
GO:0005452	inorganic anion exchanger activity	1/512	15/18367	0.345735742121078	0.597767404601863	SLC4A7	1
GO:0005545	1-phosphatidylinositol binding	1/512	15/18367	0.345735742121078	0.597767404601863	WDFY3	1
GO:0010851	cyclase regulator activity	1/512	15/18367	0.345735742121078	0.597767404601863	CALM2	1
GO:0015929	hexosaminidase activity	1/512	15/18367	0.345735742121078	0.597767404601863	HEXA	1
GO:0016805	dipeptidase activity	1/512	15/18367	0.345735742121078	0.597767404601863	PEPD	1
GO:0019215	intermediate filament binding	1/512	15/18367	0.345735742121078	0.597767404601863	VIM	1
GO:0042043	neurexin family protein binding	1/512	15/18367	0.345735742121078	0.597767404601863	SDCBP	1
GO:0045125	bioactive lipid receptor activity	1/512	15/18367	0.345735742121078	0.597767404601863	LPAR6	1
GO:0051139	metal ion:proton antiporter activity	1/512	15/18367	0.345735742121078	0.597767404601863	SLC9A9	1
GO:0071933	Arp2/3 complex binding	1/512	15/18367	0.345735742121078	0.597767404601863	GMFG	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/512	15/18367	0.345735742121078	0.597767404601863	PYCARD	1
GO:1901611	phosphatidylglycerol binding	1/512	15/18367	0.345735742121078	0.597767404601863	PLTP	1
GO:1904680	peptide transmembrane transporter activity	1/512	15/18367	0.345735742121078	0.597767404601863	SLC15A3	1
GO:0051879	Hsp90 protein binding	2/512	44/18367	0.348172908664811	0.598868982672146	HIF1A/AHR	2
GO:0019003	GDP binding	3/512	75/18367	0.348225125280293	0.598868982672146	RAP2B/RHOB/RAB8B	3
GO:0051087	chaperone binding	4/512	107/18367	0.348800718286074	0.598868982672146	HLA-B/CTSC/GRN/PRNP	4
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/512	16/18367	0.363988973378379	0.599179277316629	CPEB4	1
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/512	16/18367	0.363988973378379	0.599179277316629	ALDH1A1	1
GO:0004698	calcium-dependent protein kinase C activity	1/512	16/18367	0.363988973378379	0.599179277316629	CCL3	1
GO:0005283	amino acid:sodium symporter activity	1/512	16/18367	0.363988973378379	0.599179277316629	SLC1A3	1
GO:0005523	tropomyosin binding	1/512	16/18367	0.363988973378379	0.599179277316629	PYCARD	1
GO:0008970	phospholipase A1 activity	1/512	16/18367	0.363988973378379	0.599179277316629	PLA2G15	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/512	16/18367	0.363988973378379	0.599179277316629	SLC1A3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/512	16/18367	0.363988973378379	0.599179277316629	SLCO2B1	1
GO:0015923	mannosidase activity	1/512	16/18367	0.363988973378379	0.599179277316629	MAN1A1	1
GO:0016004	phospholipase activator activity	1/512	16/18367	0.363988973378379	0.599179277316629	CCL3	1
GO:0016208	AMP binding	1/512	16/18367	0.363988973378379	0.599179277316629	PYGL	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/512	16/18367	0.363988973378379	0.599179277316629	RNASE1	1
GO:0022821	potassium ion antiporter activity	1/512	16/18367	0.363988973378379	0.599179277316629	SLC9A9	1
GO:0035173	histone kinase activity	1/512	16/18367	0.363988973378379	0.599179277316629	JAK2	1
GO:0036122	BMP binding	1/512	16/18367	0.363988973378379	0.599179277316629	ENG	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/512	16/18367	0.363988973378379	0.599179277316629	PIK3R1	1
GO:0050135	NAD(P)+ nucleosidase activity	1/512	16/18367	0.363988973378379	0.599179277316629	TLR4	1
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	1/512	16/18367	0.363988973378379	0.599179277316629	TLR4	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	10/512	310/18367	0.364365776746599	0.599179277316629	ZEB2/IFI16/TRPS1/TFEC/SPI1/FOXO3/ETS2/ZFHX3/JUN/SKIL	10
GO:0000149	SNARE binding	4/512	110/18367	0.367856553461339	0.601831135573037	TNFAIP2/ABCA1/STX7/STX12	4
GO:0061980	regulatory RNA binding	2/512	46/18367	0.3684182492089	0.601831135573037	TLR7/NEAT1	2
GO:0140296	general transcription initiation factor binding	2/512	46/18367	0.3684182492089	0.601831135573037	TCF4/AHR	2
GO:0004518	nuclease activity	7/512	210/18367	0.369747646173675	0.602672374820528	RNASE1/ENPP2/RNASE6/PLD3/RNASET2/SAMHD1/PLSCR1	7
GO:0001217	DNA-binding transcription repressor activity	10/512	313/18367	0.375565634004803	0.606186922852693	ZEB2/IFI16/TRPS1/TFEC/SPI1/FOXO3/ETS2/ZFHX3/JUN/SKIL	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/512	47/18367	0.378448864190132	0.606186922852693	DUSP1/DUSP3	2
GO:0004697	protein kinase C activity	1/512	17/18367	0.381733927093723	0.606186922852693	CCL3	1
GO:0005324	long-chain fatty acid transporter activity	1/512	17/18367	0.381733927093723	0.606186922852693	CD36	1
GO:0008484	sulfuric ester hydrolase activity	1/512	17/18367	0.381733927093723	0.606186922852693	GNS	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	1/512	17/18367	0.381733927093723	0.606186922852693	PYCARD	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/512	17/18367	0.381733927093723	0.606186922852693	PPT1	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/512	17/18367	0.381733927093723	0.606186922852693	FTH1	1
GO:0016854	racemase and epimerase activity	1/512	17/18367	0.381733927093723	0.606186922852693	DSE	1
GO:0031420	alkali metal ion binding	1/512	17/18367	0.381733927093723	0.606186922852693	SCN9A	1
GO:0032393	MHC class I receptor activity	1/512	17/18367	0.381733927093723	0.606186922852693	LILRB5	1
GO:0070064	proline-rich region binding	1/512	17/18367	0.381733927093723	0.606186922852693	ITSN1	1
GO:0098632	cell-cell adhesion mediator activity	2/512	49/18367	0.398304299260642	0.624204439827917	SIRPA/EMB	2
GO:0005229	intracellular calcium activated chloride channel activity	1/512	18/18367	0.398984729781898	0.624204439827917	TTYH3	1
GO:0008409	5'-3' exonuclease activity	1/512	18/18367	0.398984729781898	0.624204439827917	PLD3	1
GO:0016755	aminoacyltransferase activity	1/512	18/18367	0.398984729781898	0.624204439827917	F13A1	1
GO:0060229	lipase activator activity	1/512	18/18367	0.398984729781898	0.624204439827917	CCL3	1
GO:0061778	intracellular chloride channel activity	1/512	18/18367	0.398984729781898	0.624204439827917	TTYH3	1
GO:0098918	structural constituent of synapse	1/512	18/18367	0.398984729781898	0.624204439827917	ACTB	1
GO:0004540	ribonuclease activity	4/512	116/18367	0.405828903984022	0.633572550523579	RNASE1/RNASE6/RNASET2/SAMHD1	4
GO:0019903	protein phosphatase binding	5/512	150/18367	0.407171176177373	0.634329832360539	SIRPA/IQGAP1/STAT1/STAT3/PIK3R1	5
GO:0004745	NAD-retinol dehydrogenase activity	1/512	19/18367	0.415755116089145	0.643637627418341	DHRS3	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/512	19/18367	0.415755116089145	0.643637627418341	BLVRB	1
GO:0052742	phosphatidylinositol kinase activity	1/512	19/18367	0.415755116089145	0.643637627418341	ATM	1
GO:0051018	protein kinase A binding	2/512	51/18367	0.417859748269121	0.645545331355218	PRKAR1A/AKAP13	2
GO:0000287	magnesium ion binding	7/512	221/18367	0.419962619923483	0.647442372382037	HPGDS/ATP8B4/MAP3K8/GLUL/PLSCR1/PRKACB/STK4	7
GO:0001653	peptide receptor activity	5/512	153/18367	0.423709948674678	0.648525852607845	CMKLR1/CCR1/FPR3/FPR1/OGFRL1	5
GO:0016597	amino acid binding	2/512	52/18367	0.427516373260536	0.648525852607845	GLUL/SLC1A3	2
GO:0016830	carbon-carbon lyase activity	2/512	52/18367	0.427516373260536	0.648525852607845	NPL/ME2	2
GO:0017046	peptide hormone binding	2/512	52/18367	0.427516373260536	0.648525852607845	CMKLR1/PIK3R1	2
GO:0008022	protein C-terminus binding	6/512	189/18367	0.431930515258317	0.648525852607845	ATP1B1/DAB2/TCF4/JAK2/SDCBP/NCF2	6
GO:0004551	nucleotide diphosphatase activity	1/512	20/18367	0.432058439642794	0.648525852607845	ENPP2	1
GO:0016408	C-acyltransferase activity	1/512	20/18367	0.432058439642794	0.648525852607845	SPTLC2	1
GO:0016500	protein-hormone receptor activity	1/512	20/18367	0.432058439642794	0.648525852607845	CMKLR1	1
GO:0019211	phosphatase activator activity	1/512	20/18367	0.432058439642794	0.648525852607845	CALM2	1
GO:0031418	L-ascorbic acid binding	1/512	20/18367	0.432058439642794	0.648525852607845	P4HA1	1
GO:0031690	adrenergic receptor binding	1/512	20/18367	0.432058439642794	0.648525852607845	ARRB2	1
GO:0042288	MHC class I protein binding	1/512	20/18367	0.432058439642794	0.648525852607845	HLA-E	1
GO:0070300	phosphatidic acid binding	1/512	20/18367	0.432058439642794	0.648525852607845	PLTP	1
GO:0048306	calcium-dependent protein binding	3/512	88/18367	0.446022130016706	0.658949673687491	A2M/DDX5/CALM2	3
GO:0001614	purinergic nucleotide receptor activity	1/512	21/18367	0.447907683601092	0.658949673687491	GPR34	1
GO:0005123	death receptor binding	1/512	21/18367	0.447907683601092	0.658949673687491	FEM1B	1
GO:0008373	sialyltransferase activity	1/512	21/18367	0.447907683601092	0.658949673687491	ST8SIA4	1
GO:0015125	bile acid transmembrane transporter activity	1/512	21/18367	0.447907683601092	0.658949673687491	SLCO2B1	1
GO:0015662	P-type ion transporter activity	1/512	21/18367	0.447907683601092	0.658949673687491	ATP1B1	1
GO:0016502	nucleotide receptor activity	1/512	21/18367	0.447907683601092	0.658949673687491	GPR34	1
GO:0051428	peptide hormone receptor binding	1/512	21/18367	0.447907683601092	0.658949673687491	JAK2	1
GO:0140358	P-type transmembrane transporter activity	1/512	21/18367	0.447907683601092	0.658949673687491	ATP1B1	1
GO:1990381	ubiquitin-specific protease binding	1/512	21/18367	0.447907683601092	0.658949673687491	CLTC	1
GO:0008081	phosphoric diester hydrolase activity	3/512	89/18367	0.45333147360844	0.663159474805589	ENPP2/CCR1/PLD3	3
GO:0051117	ATPase binding	3/512	89/18367	0.45333147360844	0.663159474805589	ATP1B1/ABCA1/ATP6V0A1	3
GO:0030170	pyridoxal phosphate binding	2/512	55/18367	0.455966400919071	0.663159474805589	PYGL/SPTLC2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4/512	125/18367	0.461841443118309	0.663159474805589	ASAH1/GLS/ACER3/ADAR	4
GO:0140030	modification-dependent protein binding	5/512	160/18367	0.461922921488413	0.663159474805589	LAPTM5/LYN/EPS15/PTPN6/KMT2E	5
GO:0005355	glucose transmembrane transporter activity	1/512	22/18367	0.463315470911472	0.663159474805589	SLC2A3	1
GO:0005416	amino acid:cation symporter activity	1/512	22/18367	0.463315470911472	0.663159474805589	SLC1A3	1
GO:0008093	cytoskeletal anchor activity	1/512	22/18367	0.463315470911472	0.663159474805589	SDCBP	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/512	22/18367	0.463315470911472	0.663159474805589	DHRS3	1
GO:0009975	cyclase activity	1/512	22/18367	0.463315470911472	0.663159474805589	ADCY7	1
GO:0015106	bicarbonate transmembrane transporter activity	1/512	22/18367	0.463315470911472	0.663159474805589	SLC4A7	1
GO:0015149	hexose transmembrane transporter activity	1/512	22/18367	0.463315470911472	0.663159474805589	SLC2A3	1
GO:0033691	sialic acid binding	1/512	22/18367	0.463315470911472	0.663159474805589	ST8SIA4	1
GO:0050321	tau-protein kinase activity	1/512	22/18367	0.463315470911472	0.663159474805589	TAOK1	1
GO:0051287	NAD binding	2/512	56/18367	0.465267923052538	0.663387790094177	ALDH1A1/ME2	2
GO:0070279	vitamin B6 binding	2/512	56/18367	0.465267923052538	0.663387790094177	PYGL/SPTLC2	2
GO:0022853	active ion transmembrane transporter activity	8/512	267/18367	0.468353937171297	0.666503679820691	SLCO2B1/SLC9A9/ATP1B1/SLC15A3/SLC8A1/SLC11A2/SLC1A3/SLC4A7	8
GO:0016758	hexosyltransferase activity	6/512	197/18367	0.47126329416484	0.666549180736611	MGAT4A/COLGALT1/TYMP/PYGL/MGAT1/HEXA	6
GO:0004529	exodeoxyribonuclease activity	1/512	23/18367	0.478294074285325	0.666549180736611	PLD3	1
GO:0005212	structural constituent of eye lens	1/512	23/18367	0.478294074285325	0.666549180736611	VIM	1
GO:0005248	voltage-gated sodium channel activity	1/512	23/18367	0.478294074285325	0.666549180736611	SCN9A	1
GO:0008483	transaminase activity	1/512	23/18367	0.478294074285325	0.666549180736611	BCAT1	1
GO:0015299	solute:proton antiporter activity	1/512	23/18367	0.478294074285325	0.666549180736611	SLC9A9	1
GO:0016493	C-C chemokine receptor activity	1/512	23/18367	0.478294074285325	0.666549180736611	CCR1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/512	23/18367	0.478294074285325	0.666549180736611	PLD3	1
GO:0017025	TBP-class protein binding	1/512	23/18367	0.478294074285325	0.666549180736611	AHR	1
GO:0030552	cAMP binding	1/512	23/18367	0.478294074285325	0.666549180736611	PRKAR1A	1
GO:0047617	acyl-CoA hydrolase activity	1/512	23/18367	0.478294074285325	0.666549180736611	PPT1	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/512	58/18367	0.483585034143164	0.672655874560041	SLCO2B1/CD36	2
GO:0016887	ATP hydrolysis activity	8/512	272/18367	0.48919006230713	0.675394472525619	ATP8B4/HSPA1A/RNF213/DDX60L/CHD9/IFIH1/DDX17/DDX5	8
GO:0003730	mRNA 3'-UTR binding	6/512	201/18367	0.490654102993084	0.675394472525619	ZFP36L1/CELF2/ZFP36/CPEB4/ZFP36L2/DDX5	6
GO:0036002	pre-mRNA binding	2/512	59/18367	0.492596891353096	0.675394472525619	CELF2/DDX5	2
GO:0015145	monosaccharide transmembrane transporter activity	1/512	24/18367	0.492855425897074	0.675394472525619	SLC2A3	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/512	24/18367	0.492855425897074	0.675394472525619	BCAT1	1
GO:0019789	SUMO transferase activity	1/512	24/18367	0.492855425897074	0.675394472525619	RANBP2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/512	24/18367	0.492855425897074	0.675394472525619	PYCARD	1
GO:0120014	phospholipid transfer activity	1/512	24/18367	0.492855425897074	0.675394472525619	PLTP	1
GO:0001786	phosphatidylserine binding	2/512	60/18367	0.501508756754617	0.684716752764607	GAS6/FCHO2	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/512	60/18367	0.501508756754617	0.684716752764607	TBXAS1/BLVRB	2
GO:0015291	secondary active transmembrane transporter activity	7/512	240/18367	0.505391049141719	0.688746549474903	SLCO2B1/SLC9A9/SLC15A3/SLC8A1/SLC11A2/SLC1A3/SLC4A7	7
GO:0016289	CoA hydrolase activity	1/512	25/18367	0.507011126815173	0.689684253388287	PPT1	1
GO:0043621	protein self-association	2/512	61/18367	0.510319194285738	0.692910465635681	CTSC/RSAD2	2
GO:0004435	phosphatidylinositol phospholipase C activity	1/512	26/18367	0.52077245617242	0.701478630871511	CCR1	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/512	26/18367	0.52077245617242	0.701478630871511	GLUL	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/512	26/18367	0.52077245617242	0.701478630871511	GLUL	1
GO:0030371	translation repressor activity	1/512	26/18367	0.52077245617242	0.701478630871511	CPEB4	1
GO:0061659	ubiquitin-like protein ligase activity	9/512	316/18367	0.521369252674772	0.701478630871511	WWP1/TRIM22/RNF130/RNF145/RNF149/DTX3L/RNF13/TRIM38/RANBP2	9
GO:0001671	ATPase activator activity	1/512	27/18367	0.53415038008277	0.710919570613758	ATP1B1	1
GO:0004190	aspartic-type endopeptidase activity	1/512	27/18367	0.53415038008277	0.710919570613758	CTSD	1
GO:0004683	calmodulin-dependent protein kinase activity	1/512	27/18367	0.53415038008277	0.710919570613758	MKNK1	1
GO:0030507	spectrin binding	1/512	27/18367	0.53415038008277	0.710919570613758	PTPRC	1
GO:0051119	sugar transmembrane transporter activity	1/512	27/18367	0.53415038008277	0.710919570613758	SLC2A3	1
GO:0051959	dynein light intermediate chain binding	1/512	27/18367	0.53415038008277	0.710919570613758	CCDC88A	1
GO:0004252	serine-type endopeptidase activity	5/512	174/18367	0.535772221560417	0.711797924514738	C2/CFD/CTSS/CTSC/TPP1	5
GO:0004175	endopeptidase activity	12/512	430/18367	0.539803740447546	0.715868759733304	C2/LGMN/CFD/CTSS/CTSB/CTSZ/CTSC/TPP1/ADAM9/CTSD/PYCARD/ADAM10	12
GO:0020037	heme binding	4/512	139/18367	0.544839204466775	0.719174271102343	CYBB/CYBA/TBXAS1/JAK2	4
GO:0099106	ion channel regulator activity	4/512	139/18367	0.544839204466775	0.719174271102343	SGK1/FXYD5/STX7/CALM2	4
GO:0004629	phospholipase C activity	1/512	28/18367	0.547155560311648	0.719174271102343	CCR1	1
GO:0050681	androgen receptor binding	1/512	28/18367	0.547155560311648	0.719174271102343	DDX5	1
GO:0070001	aspartic-type peptidase activity	1/512	28/18367	0.547155560311648	0.719174271102343	CTSD	1
GO:0106310	protein serine kinase activity	10/512	360/18367	0.549580818176275	0.721081215337665	BMP2K/MKNK1/MAP3K8/ATM/SGK1/PRKACB/TAOK3/MAP3K1/TAOK1/STK4	10
GO:0004033	aldo-keto reductase (NADP) activity	1/512	29/18367	0.559798362706567	0.722950765100977	DHRS3	1
GO:0005520	insulin-like growth factor binding	1/512	29/18367	0.559798362706567	0.722950765100977	IGFBP4	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/512	29/18367	0.559798362706567	0.722950765100977	BLVRB	1
GO:0032452	histone demethylase activity	1/512	29/18367	0.559798362706567	0.722950765100977	JMJD1C	1
GO:0033612	receptor serine/threonine kinase binding	1/512	29/18367	0.559798362706567	0.722950765100977	PYCARD	1
GO:0035250	UDP-galactosyltransferase activity	1/512	29/18367	0.559798362706567	0.722950765100977	COLGALT1	1
GO:0051059	NF-kappaB binding	1/512	29/18367	0.559798362706567	0.722950765100977	MTDH	1
GO:0051787	misfolded protein binding	1/512	29/18367	0.559798362706567	0.722950765100977	HSPA1A	1
GO:0140457	protein demethylase activity	1/512	29/18367	0.559798362706567	0.722950765100977	JMJD1C	1
GO:0008194	UDP-glycosyltransferase activity	4/512	143/18367	0.567326155353753	0.731396088783584	MGAT4A/COLGALT1/MGAT1/HEXA	4
GO:0005343	organic acid:sodium symporter activity	1/512	30/18367	0.57208886539466	0.734679411052594	SLC1A3	1
GO:0016417	S-acyltransferase activity	1/512	30/18367	0.57208886539466	0.734679411052594	GLUL	1
GO:0015293	symporter activity	4/512	144/18367	0.572851378618036	0.734679411052594	SLC15A3/SLC11A2/SLC1A3/SLC4A7	4
GO:0019208	phosphatase regulator activity	3/512	107/18367	0.576702434063861	0.737479003884814	ZEB2/BMP2K/CALM2	3
GO:0004521	endoribonuclease activity	2/512	69/18367	0.577027490877443	0.737479003884814	RNASE1/RNASET2	2
GO:0016247	channel regulator activity	4/512	145/18367	0.578336856808545	0.737878058686765	SGK1/FXYD5/STX7/CALM2	4
GO:0016411	acylglycerol O-acyltransferase activity	1/512	31/18367	0.584036866753548	0.739853303062902	PLA2G15	1
GO:0043015	gamma-tubulin binding	1/512	31/18367	0.584036866753548	0.739853303062902	LYN	1
GO:0090482	vitamin transmembrane transporter activity	1/512	31/18367	0.584036866753548	0.739853303062902	SLC2A3	1
GO:0001098	basal transcription machinery binding	2/512	70/18367	0.584884030124051	0.739853303062902	TCF4/AHR	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/512	70/18367	0.584884030124051	0.739853303062902	TCF4/AHR	2
GO:0008528	G protein-coupled peptide receptor activity	4/512	147/18367	0.589186517980841	0.743309276458265	CMKLR1/CCR1/FPR3/FPR1	4
GO:0008514	organic anion transmembrane transporter activity	5/512	185/18367	0.590386551998883	0.743309276458265	SLCO2B1/CD36/SLC2A3/SLC1A3/SLC4A7	5
GO:0019842	vitamin binding	4/512	148/18367	0.594549737274781	0.743309276458265	FOLR2/PYGL/P4HA1/SPTLC2	4
GO:0001222	transcription corepressor binding	1/512	32/18367	0.595651893161826	0.743309276458265	STAT1	1
GO:0008378	galactosyltransferase activity	1/512	32/18367	0.595651893161826	0.743309276458265	COLGALT1	1
GO:0031624	ubiquitin conjugating enzyme binding	1/512	32/18367	0.595651893161826	0.743309276458265	ZMYM2	1
GO:0051721	protein phosphatase 2A binding	1/512	32/18367	0.595651893161826	0.743309276458265	STAT1	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/512	32/18367	0.595651893161826	0.743309276458265	CHD9	1
GO:0043021	ribonucleoprotein complex binding	4/512	149/18367	0.599871283210501	0.745304324415377	NEAT1/CPEB4/IFIH1/DDX5	4
GO:0046906	tetrapyrrole binding	4/512	149/18367	0.599871283210501	0.745304324415377	CYBB/CYBA/TBXAS1/JAK2	4
GO:0003678	DNA helicase activity	2/512	72/18367	0.600272131556169	0.745304324415377	CHD9/SETX	2
GO:0004623	phospholipase A2 activity	1/512	33/18367	0.606943206535218	0.747134024016226	PLA2G15	1
GO:0008200	ion channel inhibitor activity	1/512	33/18367	0.606943206535218	0.747134024016226	CALM2	1
GO:0051427	hormone receptor binding	1/512	33/18367	0.606943206535218	0.747134024016226	JAK2	1
GO:0015370	solute:sodium symporter activity	2/512	73/18367	0.60780362494293	0.747134024016226	SLC1A3/SLC4A7	2
GO:0106306	protein serine phosphatase activity	2/512	73/18367	0.60780362494293	0.747134024016226	DUSP1/DUSP3	2
GO:0106307	protein threonine phosphatase activity	2/512	73/18367	0.60780362494293	0.747134024016226	DUSP1/DUSP3	2
GO:0008237	metallopeptidase activity	5/512	190/18367	0.614012852452395	0.750838523192465	LAP3/ADAM9/CPM/PEPD/ADAM10	5
GO:0017022	myosin binding	2/512	74/18367	0.615226843334572	0.750838523192465	PYCARD/GSN	2
GO:0019905	syntaxin binding	2/512	74/18367	0.615226843334572	0.750838523192465	ABCA1/STX7	2
GO:0061630	ubiquitin protein ligase activity	8/512	304/18367	0.615380296416471	0.750838523192465	WWP1/TRIM22/RNF130/RNF145/RNF149/DTX3L/RNF13/TRIM38	8
GO:0016248	channel inhibitor activity	1/512	34/18367	0.61791981165434	0.750838523192465	CALM2	1
GO:0016831	carboxy-lyase activity	1/512	34/18367	0.61791981165434	0.750838523192465	ME2	1
GO:0035198	miRNA binding	1/512	34/18367	0.61791981165434	0.750838523192465	NEAT1	1
GO:0003774	cytoskeletal motor activity	3/512	114/18367	0.619728528811974	0.751801821837476	MYO5A/MYO1F/MYO9B	3
GO:0042887	amide transmembrane transporter activity	1/512	35/18367	0.628590463289805	0.76130432542464	SLC15A3	1
GO:0000217	DNA secondary structure binding	1/512	36/18367	0.638963673130281	0.771342770173586	MEF2C	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/512	36/18367	0.638963673130281	0.771342770173586	ADAR	1
GO:0005109	frizzled binding	1/512	37/18367	0.649047716518929	0.777176877385125	SDCBP	1
GO:0015035	protein-disulfide reductase activity	1/512	37/18367	0.649047716518929	0.777176877385125	STAB1	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/512	37/18367	0.649047716518929	0.777176877385125	ALDH1A1	1
GO:0030551	cyclic nucleotide binding	1/512	37/18367	0.649047716518929	0.777176877385125	PRKAR1A	1
GO:0043531	ADP binding	1/512	37/18367	0.649047716518929	0.777176877385125	MYO9B	1
GO:0004527	exonuclease activity	2/512	80/18367	0.657506995317713	0.786034210880627	ENPP2/PLD3	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/512	38/18367	0.658850639003506	0.786370117520314	ZMYM2	1
GO:0005504	fatty acid binding	1/512	39/18367	0.668380262705301	0.793902719746265	ALOX5AP	1
GO:0019825	oxygen binding	1/512	39/18367	0.668380262705301	0.793902719746265	SOD2	1
GO:0032451	demethylase activity	1/512	39/18367	0.668380262705301	0.793902719746265	JMJD1C	1
GO:0003925	G protein activity	1/512	40/18367	0.677644192511875	0.801049045461322	RAP2B	1
GO:0015144	carbohydrate transmembrane transporter activity	1/512	40/18367	0.677644192511875	0.801049045461322	SLC2A3	1
GO:0031492	nucleosomal DNA binding	1/512	40/18367	0.677644192511875	0.801049045461322	ACTB	1
GO:0008135	translation factor activity, RNA binding	2/512	84/18367	0.68357539672101	0.805572273874303	EIF4G3/CPEB4	2
GO:0008201	heparin binding	4/512	166/18367	0.683647821612247	0.805572273874303	APOE/GPNMB/PTPRC/NRP1	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	1/512	41/18367	0.686649822098492	0.806541060877594	ATG7	1
GO:0048487	beta-tubulin binding	1/512	41/18367	0.686649822098492	0.806541060877594	TAOK1	1
GO:0042578	phosphoric ester hydrolase activity	9/512	366/18367	0.695286331985422	0.811670680503771	ENPP2/CCR1/PLD3/PTPRC/SAMHD1/DUSP1/ACP5/PTPN6/DUSP3	9
GO:0015036	disulfide oxidoreductase activity	1/512	42/18367	0.69540433978296	0.811670680503771	STAB1	1
GO:0019894	kinesin binding	1/512	42/18367	0.69540433978296	0.811670680503771	ACTB	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/512	42/18367	0.69540433978296	0.811670680503771	RSAD2	1
GO:0004519	endonuclease activity	3/512	129/18367	0.70153627058128	0.816452826523017	RNASE1/RNASE6/RNASET2	3
GO:0003727	single-stranded RNA binding	2/512	87/18367	0.702043615536824	0.816452826523017	TLR7/IFIH1	2
GO:0016790	thiolester hydrolase activity	1/512	43/18367	0.703914734218493	0.816452826523017	PPT1	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/512	43/18367	0.703914734218493	0.816452826523017	NCF4	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/512	44/18367	0.712187799929043	0.822182483537429	SGK1	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/512	44/18367	0.712187799929043	0.822182483537429	ALDH1A1	1
GO:0022839	ion gated channel activity	1/512	44/18367	0.712187799929043	0.822182483537429	TTYH3	1
GO:0015297	antiporter activity	2/512	89/18367	0.713851997364446	0.82282005926743	SLC9A9/SLC8A1	2
GO:0004721	phosphoprotein phosphatase activity	4/512	174/18367	0.718543136748822	0.826939224252144	PTPRC/DUSP1/PTPN6/DUSP3	4
GO:0015631	tubulin binding	9/512	375/18367	0.721991735490041	0.829617832705948	CCDC88A/MX2/MX1/PRNP/LYN/ARL4C/ATF5/MACF1/TAOK1	9
GO:0005272	sodium channel activity	1/512	46/18367	0.728048184768882	0.835280087951895	SCN9A	1
GO:0015085	calcium ion transmembrane transporter activity	3/512	135/18367	0.730271149021015	0.836533514358438	MCOLN1/ITPR2/SLC8A1	3
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/512	47/18367	0.735648169998855	0.840092045986346	ATP1B1	1
GO:0035254	glutamate receptor binding	1/512	47/18367	0.735648169998855	0.840092045986346	PRNP	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/512	48/18367	0.743036168741245	0.847221517516982	GLUL	1
GO:1901681	sulfur compound binding	6/512	265/18367	0.751777893407939	0.855399758660213	APOE/GPNMB/PTPRC/NRP1/MGST2/LRP1	6
GO:0045182	translation regulator activity	3/512	140/18367	0.752520598497025	0.855399758660213	EIF4G3/CPEB4/CYFIP1	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/512	50/18367	0.757199649544493	0.858082298105551	CCNL1	1
GO:0140359	ABC-type transporter activity	1/512	50/18367	0.757199649544493	0.858082298105551	ABCA1	1
GO:0004722	protein serine/threonine phosphatase activity	2/512	98/18367	0.762218323055941	0.861132151238773	DUSP1/DUSP3	2
GO:0004867	serine-type endopeptidase inhibitor activity	2/512	98/18367	0.762218323055941	0.861132151238773	A2M/SERPING1	2
GO:0003743	translation initiation factor activity	1/512	51/18367	0.76398644757	0.861813980490549	EIF4G3	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/512	52/18367	0.770583900007441	0.867933159825732	EPS15	1
GO:0008509	anion transmembrane transporter activity	7/512	314/18367	0.775962905112161	0.871178767788948	SLCO2B1/SLC9A9/CD36/TTYH3/SLC2A3/SLC1A3/SLC4A7	7
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/512	53/18367	0.776997279379332	0.871178767788948	SLC15A3	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/512	53/18367	0.776997279379332	0.871178767788948	SLCO2B1	1
GO:0052689	carboxylic ester hydrolase activity	3/512	147/18367	0.781166587795377	0.87287871481213	ENPP2/LIPA/PLA2G15	3
GO:0008374	O-acyltransferase activity	1/512	54/18367	0.783231711669262	0.87287871481213	PLA2G15	1
GO:0015459	potassium channel regulator activity	1/512	54/18367	0.783231711669262	0.87287871481213	SGK1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/512	54/18367	0.783231711669262	0.87287871481213	P4HA1	1
GO:0030374	nuclear receptor coactivator activity	1/512	56/18367	0.795183530520209	0.884865883586398	TACC1	1
GO:0004536	deoxyribonuclease activity	1/512	57/18367	0.800910472378855	0.888222714232964	PLD3	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/512	57/18367	0.800910472378855	0.888222714232964	STAB1	1
GO:0022804	active transmembrane transporter activity	9/512	406/18367	0.801801044740027	0.888222714232964	SLCO2B1/SLC9A9/ATP1B1/ABCA1/SLC15A3/SLC8A1/SLC11A2/SLC1A3/SLC4A7	9
GO:0090079	translation regulator activity, nucleic acid binding	2/512	108/18367	0.807496907204068	0.893195383155471	EIF4G3/CPEB4	2
GO:0042626	ATPase-coupled transmembrane transporter activity	2/512	109/18367	0.811575316345323	0.895377195023437	ATP1B1/ABCA1	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/512	59/18367	0.811889321433414	0.895377195023437	PLD3	1
GO:0042393	histone binding	5/512	244/18367	0.813901912423711	0.896261034514206	PARP9/JAK2/DTX3L/STAT1/KMT2E	5
GO:0004222	metalloendopeptidase activity	2/512	111/18367	0.819501618404126	0.89974955136358	ADAM9/ADAM10	2
GO:0008094	ATP-dependent activity, acting on DNA	2/512	111/18367	0.819501618404126	0.89974955136358	CHD9/SETX	2
GO:0005507	copper ion binding	1/512	61/18367	0.822263855881753	0.900111321527363	PRNP	1
GO:0015179	L-amino acid transmembrane transporter activity	1/512	61/18367	0.822263855881753	0.900111321527363	SLC1A3	1
GO:0019787	ubiquitin-like protein transferase activity	10/512	458/18367	0.825367978169851	0.902174747187134	WWP1/RNF213/TRIM22/RNF130/RNF145/RNF149/DTX3L/RNF13/TRIM38/RANBP2	10
GO:0099094	ligand-gated cation channel activity	2/512	113/18367	0.827128053480798	0.902765132117685	MCOLN1/ITPR2	2
GO:0016746	acyltransferase activity	5/512	250/18367	0.829891929402892	0.904447758112136	F13A1/GLUL/PLA2G15/SPTLC2/SAT1	5
GO:0046943	carboxylic acid transmembrane transporter activity	3/512	163/18367	0.836446700501696	0.909259729082564	SLCO2B1/CD36/SLC1A3	3
GO:0016836	hydro-lyase activity	1/512	64/18367	0.836764696628684	0.909259729082564	TBXAS1	1
GO:0005342	organic acid transmembrane transporter activity	3/512	164/18367	0.839464974635367	0.910856424091161	SLCO2B1/CD36/SLC1A3	3
GO:0002039	p53 binding	1/512	66/18367	0.845769748161127	0.91501405502812	HIF1A	1
GO:0043022	ribosome binding	1/512	66/18367	0.845769748161127	0.91501405502812	CPEB4	1
GO:0140098	catalytic activity, acting on RNA	8/512	386/18367	0.847139764265885	0.915072713679436	RNASE1/RNASE6/RNASET2/SAMHD1/DDX60L/IFIH1/DDX17/DDX5	8
GO:0005262	calcium channel activity	2/512	119/18367	0.848297137275802	0.915072713679436	MCOLN1/ITPR2	2
GO:0046873	metal ion transmembrane transporter activity	9/512	430/18367	0.850869810338787	0.916183214193951	SCN9A/SLC9A9/ATP1B1/MCOLN1/ITPR2/SLC8A1/SLC11A2/SLC1A3/SLC4A7	9
GO:0008080	N-acetyltransferase activity	1/512	68/18367	0.85427894296463	0.916183214193951	SAT1	1
GO:0051536	iron-sulfur cluster binding	1/512	68/18367	0.85427894296463	0.916183214193951	RSAD2	1
GO:0051540	metal cluster binding	1/512	68/18367	0.85427894296463	0.916183214193951	RSAD2	1
GO:0004842	ubiquitin-protein transferase activity	9/512	433/18367	0.856266673696038	0.916986018140475	WWP1/RNF213/TRIM22/RNF130/RNF145/RNF149/DTX3L/RNF13/TRIM38	9
GO:0005179	hormone activity	2/512	122/18367	0.857973824907709	0.917486460161423	IGF1/METRNL	2
GO:0003697	single-stranded DNA binding	2/512	123/18367	0.861072040800828	0.919053036702603	SAMHD1/NABP1	2
GO:0005201	extracellular matrix structural constituent	3/512	172/18367	0.861922712799468	0.919053036702603	CD4/TGFBI/FGL2	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/512	124/18367	0.864108333244504	0.920057793670407	DHRS3/ME2	2
GO:0031491	nucleosome binding	1/512	71/18367	0.866172209759765	0.92093022302044	ACTB	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4/512	222/18367	0.870022236196975	0.92347533437482	GLUL/PLA2G15/SPTLC2/SAT1	4
GO:0035064	methylated histone binding	1/512	73/18367	0.873557748732938	0.92347533437482	KMT2E	1
GO:0070063	RNA polymerase binding	1/512	73/18367	0.873557748732938	0.92347533437482	ZFP36	1
GO:0140034	methylation-dependent protein binding	1/512	73/18367	0.873557748732938	0.92347533437482	KMT2E	1
GO:0005254	chloride channel activity	1/512	74/18367	0.877096528258943	0.924741458189961	TTYH3	1
GO:0008017	microtubule binding	5/512	271/18367	0.877254734661287	0.924741458189961	CCDC88A/MX2/MX1/PRNP/MACF1	5
GO:0016791	phosphatase activity	5/512	275/18367	0.884880452382968	0.931453107771545	PTPRC/DUSP1/ACP5/PTPN6/DUSP3	5
GO:0016779	nucleotidyltransferase activity	2/512	132/18367	0.886291716931833	0.931613452456756	OAS2/OAS1	2
GO:0016835	carbon-oxygen lyase activity	1/512	79/18367	0.893361616902246	0.937712902847748	TBXAS1	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	2/512	136/18367	0.896080997572588	0.939235039948605	DHRS3/ME2	2
GO:0015171	amino acid transmembrane transporter activity	1/512	84/18367	0.907477820837871	0.948493767542407	SLC1A3	1
GO:0030165	PDZ domain binding	1/512	84/18367	0.907477820837871	0.948493767542407	PLEKHA2	1
GO:0050660	flavin adenine dinucleotide binding	1/512	85/18367	0.910068826456807	0.948520961773642	CYBB	1
GO:0015276	ligand-gated ion channel activity	2/512	143/18367	0.911349194352783	0.948520961773642	MCOLN1/ITPR2	2
GO:0022834	ligand-gated channel activity	2/512	143/18367	0.911349194352783	0.948520961773642	MCOLN1/ITPR2	2
GO:0005253	anion channel activity	1/512	87/18367	0.915035594570536	0.951020140424434	TTYH3	1
GO:0019888	protein phosphatase regulator activity	1/512	89/18367	0.919728561414291	0.954556992211185	CALM2	1
GO:0016407	acetyltransferase activity	1/512	91/18367	0.924162792827146	0.957815779680796	SAT1	1
GO:0015103	inorganic anion transmembrane transporter activity	2/512	152/18367	0.92790221165301	0.960346344927591	TTYH3/SLC4A7	2
GO:0016410	N-acyltransferase activity	1/512	94/18367	0.930359942429502	0.961545191896413	SAT1	1
GO:0015079	potassium ion transmembrane transporter activity	2/512	155/18367	0.932739416589368	0.962659927860714	SLC9A9/ATP1B1	2
GO:0008170	N-methyltransferase activity	1/512	97/18367	0.93605159069438	0.964732837205907	HNMT	1
GO:0004497	monooxygenase activity	1/512	102/18367	0.944524603783211	0.972111553267839	TBXAS1	1
GO:0016874	ligase activity	2/512	165/18367	0.94673840995584	0.97303669912128	ATG7/GLUL	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	2/512	170/18367	0.952652127570672	0.977756691265322	TBXAS1/P4HA1	2
GO:0140097	catalytic activity, acting on DNA	3/512	229/18367	0.956129425633631	0.979555149350314	PLD3/CHD9/SETX	3
GO:0030594	neurotransmitter receptor activity	1/512	111/18367	0.957051855378752	0.979555149350314	TSPO	1
GO:0004843	thiol-dependent deubiquitinase	1/512	113/18367	0.95942714920713	0.980438924759984	OTUD1	1
GO:0101005	deubiquitinase activity	1/512	114/18367	0.960565162771606	0.980438924759984	OTUD1	1
GO:0022836	gated channel activity	5/512	340/18367	0.962395967330063	0.980762905196209	CYBB/SCN9A/TTYH3/MCOLN1/ITPR2	5
GO:0015399	primary active transmembrane transporter activity	2/512	181/18367	0.963533286591411	0.980762905196209	ATP1B1/ABCA1	2
GO:0051082	unfolded protein binding	1/512	122/18367	0.968594077295111	0.984559913734041	HSPA1A	1
GO:0019783	ubiquitin-like protein-specific protease activity	1/512	125/18367	0.971164695986409	0.985288731880283	OTUD1	1
GO:0008242	omega peptidase activity	1/512	126/18367	0.971974019287306	0.985288731880283	OTUD1	1
GO:0005244	voltage-gated ion channel activity	2/512	201/18367	0.977474315916203	0.988157095325124	CYBB/SCN9A	2
GO:0022832	voltage-gated channel activity	2/512	201/18367	0.977474315916203	0.988157095325124	CYBB/SCN9A	2
GO:0016741	transferase activity, transferring one-carbon groups	2/512	225/18367	0.987492810830154	0.996155480461061	GATM/HNMT	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/512	156/18367	0.988078544132998	0.996155480461061	HNMT	1
GO:0003735	structural constituent of ribosome	1/512	182/18367	0.994323336123126	0.998157032903904	ISG15	1
GO:0005261	cation channel activity	3/512	335/18367	0.995876693131862	0.998157032903904	SCN9A/MCOLN1/ITPR2	3
GO:0015267	channel activity	5/512	480/18367	0.99765087687739	0.998157032903904	CYBB/SCN9A/TTYH3/MCOLN1/ITPR2	5
GO:0022803	passive transmembrane transporter activity	5/512	481/18367	0.997700046591014	0.998157032903904	CYBB/SCN9A/TTYH3/MCOLN1/ITPR2	5
GO:0008168	methyltransferase activity	1/512	214/18367	0.997725674027828	0.998157032903904	HNMT	1
GO:0005216	ion channel activity	4/512	432/18367	0.998157032903904	0.998157032903904	SCN9A/TTYH3/MCOLN1/ITPR2	4