ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0042110 T cell activation 67/502 487/18722 7.93145989078834e-29 3.66909334547869e-25 VSIG4/CCL2/IGF1/CD4/CD209/CD28/CR1/FCER1G/RUNX1/AIF1/CD84/FCGR2B/MAFB/CD74/GPNMB/LAPTM5/NCKAP1L/ICAM1/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/ZFP36L1/CD86/RSAD2/HLA-DQA1/HAVCR2/HLA-DQB1/SPI1/SYK/HLA-DMA/HLA-DPA1/PTGER4/HLA-E/MAP3K8/HLA-DPB1/LCP1/PAG1/PRNP/LYN/CLEC7A/CD81/PREX1/FGL2/TNFSF13B/TNFRSF14/SIRPA/PYCARD/EGR1/XBP1/TGFBR2/ZFP36L2/CD44/LGALS1/WAS/MSN/APBB1IP/PTPN6/STAT3/DUSP3/NFKBIZ/GSN/PRKAR1A 67 GO:0007159 leukocyte cell-cell adhesion 56/502 371/18722 3.15758892548347e-26 7.30350318464327e-23 VSIG4/CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/ALOX5/PAG1/PRNP/SELPLG/PECAM1/LYN/CD81/FGL2/TNFSF13B/FERMT3/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/CD44/LGALS1/KLF4/MSN/PTPN6/DUSP3/NFKBIZ/PRKAR1A 56 GO:0002683 negative regulation of immune system process 59/502 434/18722 3.68594977835875e-25 5.68373455822919e-22 C1QC/VSIG4/A2M/CCL2/TMEM176B/CD68/TMEM176A/CR1/RUNX1/TYROBP/CCL3/CD84/FCGR2B/MAFB/CD74/GPNMB/LAPTM5/NCKAP1L/BST2/SAMSN1/HLA-B/TLR4/IFI16/LGALS9/PTPRC/HLA-A/HLA-DRB1/CD86/HAVCR2/SPI1/SYK/SERPING1/SAMHD1/ARRB2/PTGER4/HLA-E/GRN/PAG1/LST1/PRNP/PARP14/LYN/ISG15/FGL2/TNFRSF14/OAS1/ATM/TSC22D3/DUSP1/GPX1/TGFB1/PTPN6/TMBIM6/DUSP3/AHR/STAT2/PIK3R1/ADAR/PRKAR1A 59 GO:1903037 regulation of leukocyte cell-cell adhesion 52/502 336/18722 6.31715767518973e-25 7.30579285135692e-22 VSIG4/CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/ALOX5/PAG1/PRNP/LYN/CD81/FGL2/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/CD44/LGALS1/KLF4/PTPN6/DUSP3/NFKBIZ/PRKAR1A 52 GO:0022407 regulation of cell-cell adhesion 58/502 448/18722 1.19699064327224e-23 1.10745574315548e-20 VSIG4/CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SPI1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/ALOX5/PAG1/PRNP/LYN/CD81/FGL2/TNFSF13B/FERMT3/JAK2/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/CD44/LGALS1/KLF4/FXYD5/TGFB1/PTPN6/DUSP3/CITED2/NFKBIZ/PRKAR1A 58 GO:1903039 positive regulation of leukocyte cell-cell adhesion 42/502 239/18722 1.71689681320833e-22 1.32372744298362e-19 CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/CD74/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/ALOX5/LYN/CD81/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/CD44/LGALS1/PTPN6/NFKBIZ 42 GO:0002697 regulation of immune effector process 49/502 339/18722 3.36713917572142e-22 2.22519797526961e-19 VSIG4/A2M/CD28/CR1/TYROBP/CD84/FCGR2B/CD74/CD36/LAPTM5/NCKAP1L/BST2/ITGB2/HLA-B/ICAM1/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/CD86/RSAD2/HAVCR2/SPI1/SYK/SERPING1/ARRB2/HLA-E/GRN/LYN/CLEC7A/CD81/FGL2/TNFRSF14/XBP1/WAS/STX7/LAMP1/TGFB1/NCF1/PTPN6/TMBIM6/AHR/NFKBIZ 49 GO:0050863 regulation of T cell activation 48/502 329/18722 6.09780518776072e-22 3.52605584982264e-19 VSIG4/CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/PAG1/PRNP/LYN/CD81/FGL2/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/LGALS1/PTPN6/DUSP3/NFKBIZ/PRKAR1A 48 GO:0045785 positive regulation of cell adhesion 55/502 437/18722 7.23268941528275e-22 3.71760235945533e-19 CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/CD74/CD36/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/RIN2/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/ADAM9/MAP3K8/HLA-DPB1/ALOX5/NRP1/LYN/CD81/PREX1/TNFSF13B/JAK2/TNFRSF14/ATM/SIRPA/PYCARD/XBP1/IQGAP1/TGFBR2/CD44/LGALS1/PLEKHA2/APBB1IP/PTPN6/ZFHX3/CITED2/NFKBIZ/STK4 55 GO:0022409 positive regulation of cell-cell adhesion 44/502 284/18722 3.01650395459405e-21 1.39543472939521e-18 CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/CD74/NCKAP1L/ITGB2/ICAM1/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/ALOX5/LYN/CD81/TNFSF13B/JAK2/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/CD44/LGALS1/PTPN6/CITED2/NFKBIZ 44 GO:0016032 viral process 52/502 415/18722 1.24953296831636e-20 5.25485410130136e-18 MRC1/CCL2/SIGLEC1/CD4/CD209/GAS6/CD28/CR1/CCL3/APOE/IFI27/CD74/CTSB/BST2/ICAM1/IFI16/LGALS9/CCL4/HLA-DRB1/IFIT1/IFITM2/CD86/RSAD2/MGAT4A/OAS2/MX1/IFITM3/ZFP36/WWP1/HSPA1A/SELPLG/NRP1/CD81/ISG15/PARP9/TNFRSF14/OAS1/EPS15/TRIM22/ATG7/PLSCR1/LGALS1/LAMP1/IFIH1/STAT1/DDX5/MGAT1/USF2/JUN/TRIM38/GSN/ADAR 52 GO:0050870 positive regulation of T cell activation 38/502 216/18722 1.81066943588413e-20 6.98013067533334e-18 CCL2/IGF1/CD4/CD209/CD28/CR1/RUNX1/AIF1/CD74/NCKAP1L/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/LYN/CD81/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/LGALS1/PTPN6/NFKBIZ 38 GO:1903706 regulation of hemopoiesis 48/502 367/18722 6.77472166533525e-20 2.41075864798776e-17 C1QC/MEF2C/TMEM176B/CD4/TMEM176A/GAS6/CD28/CR1/RUNX1/TYROBP/CCL3/FCGR2B/MAFB/CD74/CCR1/NCKAP1L/HLA-B/TLR4/LGALS9/PTPRC/HLA-DRA/B2M/HLA-DRB1/ZFP36L1/CD86/RB1/SPI1/SYK/ZFP36/HSPA1A/LYN/ISG15/FOS/FGL2/XBP1/TGFBR2/ZFP36L2/FOXO3/TGFB1/EVI2B/STAT1/PTPN6/STAT3/HIF1A/JUN/ATP6AP1/NFKBIZ/PIK3R1 48 GO:0001819 positive regulation of cytokine production 54/502 467/18722 9.09671625212286e-20 3.00581495588003e-17 CD14/CSF1R/CYBB/C3AR1/CD4/CD28/FCER1G/RUNX1/TYROBP/CCL3/AIF1/LY96/CD84/CD74/CD36/LAPTM5/TLR4/TLR7/IFI16/CYBA/LGALS9/PTPRC/B2M/HLA-A/CD86/RSAD2/POU2F2/HAVCR2/OAS2/SYK/C5AR1/HLA-DPA1/PTGER4/HLA-E/HLA-DPB1/HSPA1A/CLEC7A/CD81/ISG15/JAK2/TNFRSF14/OAS1/PYCARD/EGR1/XBP1/TGFB1/IFIH1/STAT1/ATP6AP2/GPSM3/STAT3/HIF1A/LRP1/PIK3R1 54 GO:0050867 positive regulation of cell activation 51/502 420/18722 1.20542614762713e-19 3.71753423928207e-17 MEF2C/CCL2/IGF1/CD4/CD209/GAS6/CD28/CR1/RUNX1/TYROBP/CCL3/AIF1/CD74/PLEK/NCKAP1L/ITGB2/TLR4/CTSC/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/LYN/CLEC7A/CD81/TNFSF13B/JAK2/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/LGALS1/LAMP1/TGFB1/PTPN6/NFKBIZ 51 GO:0070663 regulation of leukocyte proliferation 39/502 245/18722 2.22916215924079e-19 6.44506509290494e-17 VSIG4/CSF1R/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/BST2/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/PTPN6/AHR/PRKAR1A 39 GO:0050670 regulation of lymphocyte proliferation 37/502 225/18722 6.24302182137762e-19 1.69883640857017e-16 VSIG4/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/PTPN6/AHR/PRKAR1A 37 GO:0032944 regulation of mononuclear cell proliferation 37/502 227/18722 8.48935520916267e-19 2.18176428875481e-16 VSIG4/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/PTPN6/AHR/PRKAR1A 37 GO:0002696 positive regulation of leukocyte activation 49/502 409/18722 1.15695279483151e-18 2.81687559415292e-16 MEF2C/CCL2/IGF1/CD4/CD209/GAS6/CD28/CR1/RUNX1/TYROBP/CCL3/AIF1/CD74/NCKAP1L/ITGB2/TLR4/CTSC/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/LYN/CLEC7A/CD81/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/LGALS1/LAMP1/TGFB1/PTPN6/NFKBIZ 49 GO:0019882 antigen processing and presentation 26/502 106/18722 3.9320663702677e-18 9.09486951442918e-16 CD68/CD209/FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-B/ICAM1/HLA-DMB/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-C/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CTSD/FGL2/PYCARD/WAS/RAB8B 26 GO:0048002 antigen processing and presentation of peptide antigen 21/502 62/18722 4.35089076103658e-18 9.58439079074059e-16 CD209/FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-B/HLA-DMB/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-C/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CTSD/PYCARD 21 GO:0002443 leukocyte mediated immunity 50/502 440/18722 4.78603555891734e-18 1.0063727497978e-15 C1QA/C1QB/C1QC/C2/CD28/CR1/FCER1G/TYROBP/CCL3/CD84/FCGR2B/CD74/NCKAP1L/BST2/ITGB2/HLA-B/ICAM1/TLR4/CTSC/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/RSAD2/HLA-DQA1/HAVCR2/HLA-DQB1/SPI1/SYK/SERPING1/HLA-DMA/ARRB2/HLA-DPA1/HLA-E/HLA-DPB1/LYN/CLEC7A/CD81/WAS/STX7/LAMP1/TGFB1/PTPN6/AHR/KMT2E 50 GO:0032103 positive regulation of response to external stimulus 49/502 427/18722 7.01399825077467e-18 1.41072851774277e-15 CSF1R/C3AR1/GAS6/CD28/CMKLR1/TYROBP/CCL3/AIF1/LY96/LGMN/TMSB4X/CD74/CCR1/NCKAP1L/TLR4/TLR7/IFI16/ALOX5AP/CTSC/CYBA/LGALS9/CCL4/HAVCR2/NEAT1/SPI1/SYK/C5AR1/PTGER4/NINJ1/HLA-E/GRN/NRP1/LYN/CLEC7A/CD81/PARP9/JAK2/PYCARD/LY86/PLSCR1/TNFRSF1A/LAMP1/TGFB1/NUPR1/GPSM3/MGST2/LRP1/NFKBIZ/ADAM10 49 GO:0051251 positive regulation of lymphocyte activation 45/502 362/18722 7.65115454609059e-18 1.47476003875896e-15 MEF2C/CCL2/IGF1/CD4/CD209/GAS6/CD28/CR1/RUNX1/TYROBP/AIF1/CD74/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/HLA-DQA1/HAVCR2/HLA-DQB1/SYK/HLA-DMA/HLA-DPA1/HLA-E/MAP3K8/HLA-DPB1/LYN/CLEC7A/CD81/TNFSF13B/TNFRSF14/SIRPA/PYCARD/XBP1/TGFBR2/LGALS1/LAMP1/TGFB1/PTPN6/NFKBIZ 45 GO:0019058 viral life cycle 42/502 317/18722 9.63092614450226e-18 1.7821065737787e-15 MRC1/CCL2/SIGLEC1/CD4/CD209/GAS6/CD28/CR1/APOE/IFI27/CD74/CTSB/BST2/ICAM1/IFI16/LGALS9/HLA-DRB1/IFIT1/IFITM2/CD86/RSAD2/OAS2/MX1/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/ISG15/TNFRSF14/OAS1/EPS15/TRIM22/PLSCR1/LGALS1/LAMP1/IFIH1/DDX5/TRIM38/GSN/ADAR 42 GO:0002478 antigen processing and presentation of exogenous peptide antigen 17/502 38/18722 2.50736181055382e-17 4.46117528293152e-15 FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-DMB/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CTSD 17 GO:0002831 regulation of response to biotic stimulus 42/502 327/18722 3.03989608347419e-17 5.20835528968578e-15 VSIG4/A2M/CR1/TYROBP/LY96/FCGR2B/APOE/CD36/HLA-B/TLR4/IFI16/CYBA/LGALS9/HLA-A/HLA-DRB1/IFIT1/HAVCR2/SPI1/SYK/SERPING1/SAMHD1/ARRB2/HLA-E/GRN/PARP14/LYN/CLEC7A/ISG15/PARP9/FGL2/OAS1/PYCARD/LY86/PLSCR1/DTX3L/LAMP1/NCF1/STAT1/PTPN6/AHR/STAT2/ADAR 42 GO:0071706 tumor necrosis factor superfamily cytokine production 32/502 186/18722 3.98457609639559e-17 6.35608586962966e-15 CD14/CYBB/IGF1/GAS6/TYROBP/CCL3/LY96/CD84/CD36/GPNMB/TLR4/CYBA/LGALS9/PTPRC/CD86/HAVCR2/OAS2/SYK/ZFP36/ARRB2/HLA-E/CLEC7A/JAK2/OAS1/SIRPA/PYCARD/TSPO/ACP5/IFIH1/PTPN6/STAT3/PIK3R1 32 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 32/502 186/18722 3.98457609639559e-17 6.35608586962966e-15 CD14/CYBB/IGF1/GAS6/TYROBP/CCL3/LY96/CD84/CD36/GPNMB/TLR4/CYBA/LGALS9/PTPRC/CD86/HAVCR2/OAS2/SYK/ZFP36/ARRB2/HLA-E/CLEC7A/JAK2/OAS1/SIRPA/PYCARD/TSPO/ACP5/IFIH1/PTPN6/STAT3/PIK3R1 32 GO:0002764 immune response-regulating signaling pathway 50/502 468/18722 6.31962079467096e-17 9.74485526538263e-15 CD14/MEF2C/C3AR1/CD28/CR1/CMKLR1/FCER1G/TYROBP/LY96/FCGR2B/CTSS/CD36/LAPTM5/NCKAP1L/TLR4/TLR7/CYBA/PTPRC/HLA-A/FCGR1B/HLA-DRB1/UNC93B1/LCP2/RSAD2/PIK3AP1/HAVCR2/HLA-DQB1/FPR3/SYK/C5AR1/ARRB2/NINJ1/HLA-DPB1/HSPA1A/PRNP/SLC15A3/FPR1/LYN/CLEC7A/CD81/OAS1/PLSCR1/CMTM3/IFIH1/PTPN6/RTN4/DUSP3/COLEC12/MAP3K1/NFKBIZ 50 GO:0031348 negative regulation of defense response 37/502 258/18722 6.6664923707938e-17 9.9481270023523e-15 VSIG4/A2M/IGF1/CR1/FCGR2B/APOE/HLA-B/IFI16/LGALS9/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/METRNL/RB1/HAVCR2/SYK/SERPING1/SAMHD1/ZFP36/ARRB2/PTGER4/HLA-E/ALOX5/GRN/PARP14/LYN/ISG15/FGL2/OAS1/SIRPA/GPX1/ACP5/TNFRSF1A/KLF4/STAT2/ADAR 37 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 16/502 34/18722 7.96607870293845e-17 1.15159625249354e-14 FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/CTSD/PYCARD 16 GO:0050777 negative regulation of immune response 32/502 194/18722 1.42328633687432e-16 1.81931409271752e-14 VSIG4/A2M/CR1/CD84/FCGR2B/NCKAP1L/SAMSN1/HLA-B/IFI16/LGALS9/PTPRC/HLA-A/HLA-DRB1/HAVCR2/SPI1/SYK/SERPING1/SAMHD1/ARRB2/HLA-E/GRN/PARP14/LYN/ISG15/FGL2/TNFRSF14/OAS1/GPX1/PTPN6/AHR/STAT2/ADAR 32 GO:0032640 tumor necrosis factor production 31/502 181/18722 1.42768391156377e-16 1.81931409271752e-14 CD14/CYBB/IGF1/GAS6/TYROBP/CCL3/LY96/CD84/CD36/GPNMB/TLR4/CYBA/LGALS9/PTPRC/HAVCR2/OAS2/SYK/ZFP36/ARRB2/HLA-E/CLEC7A/JAK2/OAS1/SIRPA/PYCARD/TSPO/ACP5/IFIH1/PTPN6/STAT3/PIK3R1 31 GO:0032680 regulation of tumor necrosis factor production 31/502 181/18722 1.42768391156377e-16 1.81931409271752e-14 CD14/CYBB/IGF1/GAS6/TYROBP/CCL3/LY96/CD84/CD36/GPNMB/TLR4/CYBA/LGALS9/PTPRC/HAVCR2/OAS2/SYK/ZFP36/ARRB2/HLA-E/CLEC7A/JAK2/OAS1/SIRPA/PYCARD/TSPO/ACP5/IFIH1/PTPN6/STAT3/PIK3R1 31 GO:0002263 cell activation involved in immune response 38/502 279/18722 1.45513665003347e-16 1.81931409271752e-14 CD28/CR1/FCER1G/TYROBP/CCL3/CD84/FCGR2B/CD74/NCKAP1L/ITGB2/ICAM1/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-DRA/ITGAM/HLA-DRB1/CD86/HAVCR2/SPI1/SYK/PTGER4/LCP1/GRN/LYN/CLEC7A/CD81/FGL2/PYCARD/XBP1/LGALS1/LAMP1/TGFB1/APBB1IP/STAT3/LRP1/NFKBIZ 38 GO:1902105 regulation of leukocyte differentiation 38/502 279/18722 1.45513665003347e-16 1.81931409271752e-14 C1QC/TMEM176B/CD4/TMEM176A/GAS6/CD28/CR1/RUNX1/TYROBP/CCL3/FCGR2B/MAFB/CD74/CCR1/NCKAP1L/HLA-B/TLR4/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/ZFP36L1/CD86/RB1/SYK/LYN/FOS/FGL2/XBP1/TGFBR2/ZFP36L2/TGFB1/EVI2B/PTPN6/JUN/ATP6AP1/NFKBIZ/PIK3R1 38 GO:0002274 myeloid leukocyte activation 34/502 223/18722 1.87782358291875e-16 2.2860031301532e-14 C1QA/VSIG4/FCER1G/CD93/TYROBP/CCL3/AIF1/CD84/FCGR2B/CD74/ITGB2/TLR4/CTSC/LGALS9/PTPRC/ITGAM/LCP2/RBPJ/HAVCR2/SPI1/SYK/C5AR1/ADAM9/GRN/LYN/PREX1/NAMPT/JAK2/PYCARD/TGFBR2/PLSCR1/IFNGR2/ADAM10/KMT2E 34 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 15/502 30/18722 2.32132731495609e-16 2.75345132281714e-14 FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/CTSD 15 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 16/502 36/18722 2.51387581916853e-16 2.9072973848684e-14 FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/CTSD/PYCARD 16 GO:0002703 regulation of leukocyte mediated immunity 34/502 226/18722 2.84997897571539e-16 3.21561042479497e-14 CD28/CR1/TYROBP/CD84/FCGR2B/NCKAP1L/BST2/ITGB2/HLA-B/ICAM1/TLR4/LGALS9/PTPRC/TNFRSF1B/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/RSAD2/HAVCR2/SPI1/SYK/ARRB2/HLA-E/LYN/CLEC7A/CD81/WAS/STX7/LAMP1/TGFB1/PTPN6/AHR 34 GO:0030099 myeloid cell differentiation 44/502 381/18722 2.91954070761838e-16 3.21566555081967e-14 C1QC/CSF1R/MEF2C/CD4/RUNX1/TYROBP/CCL3/MAFB/CD74/CCR1/NCKAP1L/TLR4/IFI16/B2M/HLA-DRB1/ZFP36L1/RB1/RBPJ/SPI1/ZFP36/KLF2/HSPA1A/LYN/CD81/ISG15/FOS/JUNB/JAK2/SLC11A2/TGFBR2/FOXO3/TGFB1/EVI2B/STAT1/PTPN6/STAT3/HIF1A/ABI1/JUN/CITED2/ATP6AP1/PIK3R1/ADAR/KMT2E 44 GO:0070661 leukocyte proliferation 40/502 318/18722 3.70382889481547e-16 3.9846308063759e-14 VSIG4/CSF1R/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/BST2/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/MSN/PTPN6/AHR/PRKAR1A 40 GO:0046651 lymphocyte proliferation 38/502 288/18722 4.24502592999553e-16 4.46306589821803e-14 VSIG4/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/MSN/PTPN6/AHR/PRKAR1A 38 GO:0002366 leukocyte activation involved in immune response 37/502 275/18722 5.53602895838269e-16 5.69103776921741e-14 CD28/CR1/FCER1G/TYROBP/CCL3/CD84/FCGR2B/CD74/NCKAP1L/ITGB2/ICAM1/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-DRA/ITGAM/HLA-DRB1/CD86/HAVCR2/SPI1/SYK/PTGER4/LCP1/GRN/LYN/CLEC7A/CD81/FGL2/PYCARD/XBP1/LGALS1/LAMP1/TGFB1/APBB1IP/STAT3/NFKBIZ 37 GO:0032943 mononuclear cell proliferation 38/502 291/18722 6.00749249750907e-16 6.04144788988629e-14 VSIG4/MEF2C/IGF1/CD209/CD28/CR1/TYROBP/AIF1/FCGR2B/CD74/GPNMB/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LST1/PRNP/LYN/CD81/TNFSF13B/TNFRSF14/ATM/PYCARD/TGFBR2/MSN/PTPN6/AHR/PRKAR1A 38 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 42/502 356/18722 6.67129595131546e-16 6.56625852569901e-14 C1QA/C1QB/C1QC/MEF2C/C2/CD4/CD28/CR1/FCER1G/FCGR2B/CD74/NCKAP1L/HLA-B/ICAM1/TLR4/CTSC/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-DQA1/HAVCR2/HLA-DQB1/SERPING1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CLEC7A/CD81/TNFSF13B/WAS/STX7/TGFB1/PTPN6/STAT3/AHR/NFKBIZ 42 GO:0046718 viral entry into host cell 27/502 144/18722 1.29220504819667e-15 1.24536261519954e-13 MRC1/SIGLEC1/CD4/CD209/GAS6/CR1/CD74/CTSB/ICAM1/LGALS9/HLA-DRB1/IFITM2/CD86/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/TNFRSF14/EPS15/TRIM22/PLSCR1/LGALS1/LAMP1/TRIM38/GSN 27 GO:0002237 response to molecule of bacterial origin 42/502 363/18722 1.33805512561689e-15 1.26323326757219e-13 MRC1/CD14/MEF2C/CCL2/CD68/CCL3/LY96/FCGR2B/CD36/ICAM1/TLR4/LGALS9/TNFRSF1B/B2M/CD86/HAVCR2/IL10RA/SPI1/C5AR1/ZFP36/PTGER4/ADAM9/ABCA1/MTDH/LYN/FOS/JAK2/SOD2/SGMS1/SIRPA/PYCARD/LY86/XBP1/VIM/TSPO/ACP5/NR4A1/TGFB1/MGST2/LITAF/JUN/IFNAR1 42 GO:0019884 antigen processing and presentation of exogenous antigen 17/502 47/18722 1.91078835110564e-15 1.76786138244294e-13 FCER1G/FCGR2B/LGMN/CTSS/CD74/HLA-DMB/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CTSD 17 GO:0044409 entry into host 27/502 151/18722 4.44885590160479e-15 3.99357836916438e-13 MRC1/SIGLEC1/CD4/CD209/GAS6/CR1/CD74/CTSB/ICAM1/LGALS9/HLA-DRB1/IFITM2/CD86/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/TNFRSF14/EPS15/TRIM22/PLSCR1/LGALS1/LAMP1/TRIM38/GSN 27 GO:0045088 regulation of innate immune response 32/502 218/18722 4.4891066838856e-15 3.99357836916438e-13 VSIG4/A2M/CR1/TYROBP/FCGR2B/APOE/HLA-B/TLR4/IFI16/LGALS9/HLA-A/HAVCR2/SPI1/SYK/SERPING1/SAMHD1/ARRB2/HLA-E/GRN/PARP14/LYN/CLEC7A/ISG15/PARP9/OAS1/PYCARD/PLSCR1/LAMP1/NCF1/PTPN6/STAT2/ADAR 32 GO:0032496 response to lipopolysaccharide 40/502 343/18722 5.01100762277108e-15 4.37375872885642e-13 MRC1/CD14/MEF2C/CCL2/CD68/CCL3/LY96/CD36/ICAM1/TLR4/LGALS9/TNFRSF1B/CD86/HAVCR2/IL10RA/SPI1/C5AR1/ZFP36/PTGER4/ADAM9/ABCA1/MTDH/LYN/FOS/JAK2/SOD2/SGMS1/SIRPA/PYCARD/LY86/XBP1/VIM/TSPO/ACP5/NR4A1/TGFB1/MGST2/LITAF/JUN/IFNAR1 40 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 35/502 264/18722 5.51734608857301e-15 4.72652648254422e-13 CSF1R/IGF1/CD4/ENPP2/GAS6/PDGFC/CD74/CD36/SAMSN1/ITGB2/ICAM1/FCGR1A/PTPRC/SYK/ARRB2/PRNP/PARP14/PECAM1/NRP1/LYN/CLEC7A/CD81/RAP2B/EHD4/PARP9/JAK2/TNFRSF14/IQGAP1/SNX6/CD44/TNFRSF1A/TGFB1/NCF1/PTPN6/ABI1 35 GO:0070997 neuron death 41/502 361/18722 5.63809664820503e-15 4.74215183538117e-13 C1QA/MEF2C/CCL2/TYROBP/CCL3/FCGR2B/LGMN/APOE/NAIP/GPNMB/CTSZ/ITGB2/TLR4/TNFRSF1B/ITGAM/RB1/NR4A2/C5AR1/ARRB2/GRN/PRNP/NRP1/FOS/NAMPT/JAK2/SOD2/CPEB4/EGR1/BTG2/ATG7/GPX1/SNX6/FOXO3/REL/PPT1/MCL1/NUPR1/STAT3/HIF1A/JUN/LRP1 41 GO:0070371 ERK1 and ERK2 cascade 39/502 330/18722 7.15950054298672e-15 5.91425884140296e-13 CSF1R/CCL2/IGF1/CD4/SPRED1/GAS6/CCL3/PDGFC/APOE/CD74/CD36/GPNMB/CCR1/ICAM1/TLR4/LGALS9/PTPRC/CCL4/HLA-DRB1/ZFP36L1/HAVCR2/SYK/C5AR1/ARRB2/PTGER4/NRP1/LYN/SIRPA/PYCARD/DUSP1/ZFP36L2/CD44/KLF4/TGFB1/PTPN6/GNAI2/DUSP3/LRP1/ATP6AP1 39 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 23/502 107/18722 7.66653377539478e-15 6.22199741139935e-13 CD14/CYBB/TYROBP/CCL3/LY96/CD84/CD36/TLR4/CYBA/LGALS9/PTPRC/CD86/HAVCR2/OAS2/SYK/HLA-E/CLEC7A/JAK2/OAS1/PYCARD/IFIH1/STAT3/PIK3R1 23 GO:0019221 cytokine-mediated signaling pathway 47/502 472/18722 8.51996056969426e-15 6.79540303369063e-13 CSF1R/CCL2/LILRB5/CD4/GAS6/CMKLR1/FCER1G/CCL3/TMSB4X/IFI27/CD74/LAPTM5/CCR1/PTPRC/TNFRSF1B/CCL4/IFITM2/IL10RA/OAS2/MX1/IFITM3/SPI1/SYK/SAMHD1/HSPA1A/PARP14/ISG15/PARP9/TNFSF13B/JAK2/TNFRSF14/OAS1/PYCARD/EGR1/IFNGR2/CD44/FOXO3/TNFRSF1A/STAT1/IL13RA1/PTPN6/STAT3/HIF1A/SP100/STAT2/IFNAR1/ADAR 47 GO:0009615 response to virus 41/502 367/18722 9.94962922034374e-15 7.80118385988308e-13 IFI44L/IFI27/BST2/RNASE6/TLR7/IFI16/NPC2/LGALS9/PTPRC/CCL4/IFI44/IFIT1/UNC93B1/IFITM2/RSAD2/POU2F2/OAS2/MX2/MX1/IFITM3/SAMHD1/ISG15/PARP9/FGL2/OAS1/PYCARD/TRIM22/ATG7/IFIT3/PLSCR1/IFNGR2/DTX3L/IFIH1/STAT1/IVNS1ABP/HIF1A/DDX17/STAT2/IFNAR1/BNIP3L/ADAR 41 GO:0002819 regulation of adaptive immune response 29/502 183/18722 1.15143510382935e-14 8.8775646505243e-13 MEF2C/CD4/CD28/CR1/FCGR2B/NCKAP1L/SAMSN1/HLA-B/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HAVCR2/HLA-E/CLEC7A/CD81/TNFSF13B/TNFRSF14/PYCARD/WAS/STX7/TGFB1/PTPN6/ADCY7/AHR/NFKBIZ 29 GO:1901214 regulation of neuron death 38/502 319/18722 1.24377913254425e-14 9.43233158549128e-13 C1QA/MEF2C/CCL2/TYROBP/CCL3/FCGR2B/LGMN/APOE/NAIP/GPNMB/CTSZ/ITGB2/TLR4/TNFRSF1B/ITGAM/NR4A2/C5AR1/ARRB2/GRN/PRNP/NRP1/FOS/JAK2/SOD2/CPEB4/EGR1/BTG2/ATG7/SNX6/FOXO3/REL/PPT1/MCL1/NUPR1/STAT3/HIF1A/JUN/LRP1 38 GO:0042129 regulation of T cell proliferation 28/502 171/18722 1.41807789304923e-14 1.05806908600738e-12 VSIG4/IGF1/CD209/CD28/CR1/AIF1/GPNMB/NCKAP1L/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/PRNP/CD81/TNFSF13B/TNFRSF14/PYCARD/TGFBR2/PTPN6/PRKAR1A 28 GO:0032760 positive regulation of tumor necrosis factor production 22/502 103/18722 3.41671675782431e-14 2.50884630503099e-12 CD14/CYBB/TYROBP/CCL3/LY96/CD84/CD36/TLR4/CYBA/LGALS9/PTPRC/HAVCR2/OAS2/SYK/HLA-E/CLEC7A/JAK2/OAS1/PYCARD/IFIH1/STAT3/PIK3R1 22 GO:0002699 positive regulation of immune effector process 32/502 235/18722 3.90352110226814e-14 2.82151384673319e-12 CD28/CR1/TYROBP/CD84/CD74/CD36/LAPTM5/ITGB2/HLA-B/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/CD86/RSAD2/SPI1/SYK/HLA-E/LYN/CLEC7A/CD81/TNFRSF14/XBP1/STX7/LAMP1/TGFB1/NFKBIZ 32 GO:0032102 negative regulation of response to external stimulus 43/502 420/18722 4.77569153249232e-14 3.34747681553598e-12 SPP1/VSIG4/A2M/CCL2/IGF1/CR1/AIF1/FCGR2B/APOE/HLA-B/IFI16/LGALS9/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/METRNL/RB1/HAVCR2/SYK/SERPING1/SAMHD1/ZFP36/ARRB2/PTGER4/HLA-E/ALOX5/GRN/PARP14/NRP1/LYN/ISG15/FGL2/OAS1/SIRPA/DUSP1/GPX1/ACP5/TNFRSF1A/KLF4/DUSP3/STAT2/ADAR 43 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 29/502 193/18722 4.77590725951956e-14 3.34747681553598e-12 CSF1R/IGF1/CD4/ENPP2/GAS6/CD74/CD36/ICAM1/FCGR1A/PTPRC/SYK/ARRB2/PRNP/PARP14/PECAM1/NRP1/LYN/CLEC7A/CD81/EHD4/PARP9/JAK2/TNFRSF14/IQGAP1/CD44/TNFRSF1A/TGFB1/NCF1/ABI1 29 GO:0045637 regulation of myeloid cell differentiation 30/502 210/18722 6.86445628321531e-14 4.7395484725603e-12 C1QC/MEF2C/CD4/RUNX1/TYROBP/CCL3/MAFB/CD74/CCR1/NCKAP1L/TLR4/B2M/HLA-DRB1/ZFP36L1/RB1/SPI1/ZFP36/HSPA1A/LYN/ISG15/FOS/FOXO3/TGFB1/EVI2B/STAT1/STAT3/HIF1A/JUN/ATP6AP1/PIK3R1 30 GO:1903131 mononuclear cell differentiation 43/502 426/18722 7.83077719743889e-14 5.3272316640224e-12 CSF1R/TMEM176B/CD4/TMEM176A/GAS6/CD28/CR1/FCER1G/RUNX1/FCGR2B/MAFB/CD74/NCKAP1L/HLA-B/IFI16/LGALS9/PTPRC/HLA-DRA/B2M/HLA-DRB1/ZFP36L1/KLF6/CD86/RSAD2/RBPJ/SPI1/SYK/PTGER4/LYN/PREX1/FGL2/TNFSF13B/ATM/EGR1/XBP1/TGFBR2/ZFP36L2/LGALS1/PTPN6/STAT3/JUN/NFKBIZ/PIK3R1 43 GO:0044403 biological process involved in symbiotic interaction 35/502 290/18722 9.67449604840922e-14 6.48611865506392e-12 MRC1/SIGLEC1/CD4/CD209/GAS6/CR1/CCL3/APOE/IFI27/CD74/CTSB/ICAM1/LGALS9/CCL4/HLA-DRB1/IFIT1/IFITM2/CD86/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/TNFRSF14/EPS15/TRIM22/ATG7/PLSCR1/GPX1/LGALS1/LAMP1/JUN/TRIM38/GSN 35 GO:0002253 activation of immune response 40/502 375/18722 9.93767512784681e-14 6.56738359163133e-12 C1QA/C1QB/C1QC/VSIG4/A2M/MEF2C/C2/C3AR1/CD28/CR1/CMKLR1/FCER1G/TYROBP/FCGR2B/CFD/LAPTM5/NCKAP1L/TLR4/IFI16/PTPRC/HLA-A/HLA-DRB1/LCP2/HLA-DQB1/FPR3/SYK/SERPING1/C5AR1/HLA-DPB1/PRNP/FPR1/LYN/CLEC7A/CD81/PYCARD/PLSCR1/CMTM3/PTPN6/DUSP3/NFKBIZ 40 GO:0042098 T cell proliferation 29/502 199/18722 1.07259917836026e-13 6.98851239309093e-12 VSIG4/IGF1/CD209/CD28/CR1/AIF1/GPNMB/NCKAP1L/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-A/HLA-DRB1/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/PRNP/CD81/TNFSF13B/TNFRSF14/PYCARD/TGFBR2/MSN/PTPN6/PRKAR1A 29 GO:0070372 regulation of ERK1 and ERK2 cascade 36/502 309/18722 1.25456020215234e-13 8.06054929882881e-12 CSF1R/CCL2/IGF1/CD4/SPRED1/GAS6/CCL3/PDGFC/APOE/CD74/CD36/GPNMB/CCR1/ICAM1/TLR4/LGALS9/PTPRC/CCL4/HLA-DRB1/HAVCR2/SYK/C5AR1/ARRB2/NRP1/LYN/SIRPA/PYCARD/DUSP1/CD44/KLF4/TGFB1/PTPN6/GNAI2/DUSP3/LRP1/ATP6AP1 36 GO:0071216 cellular response to biotic stimulus 32/502 246/18722 1.42435281953535e-13 8.88199147703075e-12 MRC1/CD14/MEF2C/CCL2/CD68/CCL3/LY96/FCGR2B/CD36/ICAM1/TLR4/TNFRSF1B/TXNIP/CD86/HAVCR2/SPI1/SYK/ZFP36/ADAM9/ABCA1/MTDH/LYN/CLEC7A/SGMS1/SIRPA/PYCARD/LY86/XBP1/VIM/TSPO/TGFB1/LITAF 32 GO:0002698 negative regulation of immune effector process 22/502 110/18722 1.43915548722863e-13 8.88199147703075e-12 VSIG4/A2M/CR1/CD84/FCGR2B/NCKAP1L/BST2/HLA-B/LGALS9/PTPRC/HLA-A/HAVCR2/SPI1/SERPING1/ARRB2/HLA-E/GRN/FGL2/TGFB1/PTPN6/TMBIM6/AHR 22 GO:0002695 negative regulation of leukocyte activation 28/502 187/18722 1.44001158836426e-13 8.88199147703075e-12 VSIG4/CR1/RUNX1/TYROBP/CD84/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/SAMSN1/LGALS9/PTPRC/HLA-DRB1/CD86/HAVCR2/SPI1/GRN/PAG1/LST1/PRNP/LYN/FGL2/TNFRSF14/ATM/PTPN6/DUSP3/PRKAR1A 28 GO:0051701 biological process involved in interaction with host 29/502 203/18722 1.80811738800706e-13 1.10057250485798e-11 MRC1/SIGLEC1/CD4/CD209/GAS6/CR1/CD74/CTSB/ICAM1/LGALS9/HLA-DRB1/IFIT1/IFITM2/CD86/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/TNFRSF14/EPS15/TRIM22/ATG7/PLSCR1/LGALS1/LAMP1/TRIM38/GSN 29 GO:0052126 movement in host environment 27/502 175/18722 1.88138205783215e-13 1.13029524669241e-11 MRC1/SIGLEC1/CD4/CD209/GAS6/CR1/CD74/CTSB/ICAM1/LGALS9/HLA-DRB1/IFITM2/CD86/IFITM3/WWP1/HSPA1A/SELPLG/NRP1/CD81/TNFRSF14/EPS15/TRIM22/PLSCR1/LGALS1/LAMP1/TRIM38/GSN 27 GO:0051607 defense response to virus 33/502 265/18722 2.05946700089155e-13 1.20596130963599e-11 IFI44L/IFI27/BST2/RNASE6/TLR7/IFI16/PTPRC/IFIT1/UNC93B1/IFITM2/RSAD2/OAS2/MX2/MX1/IFITM3/SAMHD1/ISG15/PARP9/FGL2/OAS1/PYCARD/TRIM22/ATG7/IFIT3/PLSCR1/IFNGR2/DTX3L/IFIH1/STAT1/DDX17/STAT2/BNIP3L/ADAR 33 GO:0140546 defense response to symbiont 33/502 265/18722 2.05946700089155e-13 1.20596130963599e-11 IFI44L/IFI27/BST2/RNASE6/TLR7/IFI16/PTPRC/IFIT1/UNC93B1/IFITM2/RSAD2/OAS2/MX2/MX1/IFITM3/SAMHD1/ISG15/PARP9/FGL2/OAS1/PYCARD/TRIM22/ATG7/IFIT3/PLSCR1/IFNGR2/DTX3L/IFIH1/STAT1/DDX17/STAT2/BNIP3L/ADAR 33 GO:0002449 lymphocyte mediated immunity 38/502 350/18722 2.42115602698297e-13 1.4000334726029e-11 C1QA/C1QB/C1QC/C2/CD28/CR1/FCER1G/FCGR2B/CD74/NCKAP1L/HLA-B/ICAM1/CTSC/LGALS9/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-DQA1/HAVCR2/HLA-DQB1/SERPING1/HLA-DMA/ARRB2/HLA-DPA1/HLA-E/HLA-DPB1/CD81/WAS/STX7/LAMP1/TGFB1/PTPN6/AHR 38 GO:0070665 positive regulation of leukocyte proliferation 25/502 150/18722 2.47804137157835e-13 1.41523696110141e-11 CSF1R/MEF2C/IGF1/CD209/CD28/AIF1/CD74/NCKAP1L/BST2/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-A/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/LYN/CD81/TNFSF13B/PYCARD/TGFBR2 25 GO:0050792 regulation of viral process 26/502 164/18722 2.75902647270913e-13 1.55649469057956e-11 CD4/CD209/CD28/CD74/BST2/IFI16/LGALS9/HLA-DRB1/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ZFP36/ISG15/OAS1/TRIM22/PLSCR1/LGALS1/IFIH1/STAT1/DDX5/TRIM38/GSN/ADAR 26 GO:0045824 negative regulation of innate immune response 18/502 71/18722 3.17228618169053e-13 1.76807179234945e-11 VSIG4/A2M/CR1/HLA-B/IFI16/LGALS9/HLA-A/HAVCR2/SERPING1/SAMHD1/ARRB2/HLA-E/GRN/PARP14/ISG15/OAS1/STAT2/ADAR 18 GO:0007162 negative regulation of cell adhesion 35/502 303/18722 3.57890708382058e-13 1.97095525830405e-11 VSIG4/CR1/RUNX1/FCGR2B/CD74/GPNMB/LAPTM5/PLXND1/NCKAP1L/TGFBI/LGALS9/PTPRC/HLA-DRB1/CD86/HAVCR2/SPI1/PAG1/PRNP/FGL2/JAK2/TNFRSF14/DUSP1/LGALS1/KLF4/FXYD5/TGFB1/ARHGDIB/PTPN6/DUSP3/LRP1/CD164/PIK3R1/ADAM10/PRKAR1A/PLXNB2 35 GO:0050866 negative regulation of cell activation 29/502 210/18722 4.37104762758545e-13 2.37887839120121e-11 VSIG4/CR1/RUNX1/TYROBP/CD84/FCGR2B/APOE/CD74/GPNMB/LAPTM5/NCKAP1L/SAMSN1/LGALS9/PTPRC/HLA-DRB1/CD86/HAVCR2/SPI1/GRN/PAG1/LST1/PRNP/LYN/FGL2/TNFRSF14/ATM/PTPN6/DUSP3/PRKAR1A 29 GO:0034341 response to interferon-gamma 24/502 141/18722 4.65515111829357e-13 2.50403826432861e-11 MRC1/CCL2/CCL3/AIF1/CD74/BST2/ICAM1/TLR4/LGALS9/CCL4/IFITM2/IFITM3/CXCL16/HLA-DPA1/PARP14/PARP9/JAK2/SIRPA/VIM/IFNGR2/ACTR2/WAS/STAT1/SP100 24 GO:0042116 macrophage activation 21/502 106/18722 6.30579331495459e-13 3.35294251436551e-11 C1QA/VSIG4/CD93/TYROBP/CCL3/AIF1/CD84/FCGR2B/CD74/ITGB2/TLR4/CTSC/PTPRC/ITGAM/HAVCR2/SYK/C5AR1/GRN/NAMPT/JAK2/IFNGR2 21 GO:0006898 receptor-mediated endocytosis 31/502 244/18722 6.55207046791889e-13 3.444304316431e-11 MRC1/CD14/STAB1/SIGLEC1/FCER1G/FCGR2B/APOE/DAB2/CD36/MSR1/ITGB2/BMP2K/B2M/ITGAM/ITSN1/CXCL16/SYK/ARRB2/CD81/CLTC/CD63/FCHSD2/EPS15/ITSN2/TGFBR2/AP2A2/SDCBP/PPT1/FCHO2/DNAJC13/LRP1 31 GO:0043410 positive regulation of MAPK cascade 44/502 480/18722 1.14675401979477e-12 5.96054392760743e-11 CSF1R/CCL2/IGF1/CD4/GAS6/IGFBP4/CCL3/FCGR2B/PDGFC/APOE/CD74/CD36/GPNMB/LAPTM5/CCR1/ICAM1/TLR4/LGALS9/PTPRC/CCL4/HLA-DRB1/HAVCR2/TIMP2/SPI1/SYK/C5AR1/ARRB2/ADAM9/NRP1/CLEC7A/CD81/PYCARD/IQGAP1/SDCBP/CD44/GADD45B/TGFB1/NCF1/GNAI2/TAOK3/LRP1/ATP6AP1/TAOK1/AKAP13 44 GO:1903900 regulation of viral life cycle 24/502 148/18722 1.38850124507452e-12 7.13689639968305e-11 CD4/CD209/CD28/CD74/BST2/IFI16/LGALS9/HLA-DRB1/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ISG15/OAS1/TRIM22/PLSCR1/LGALS1/IFIH1/DDX5/TRIM38/GSN/ADAR 24 GO:0031341 regulation of cell killing 20/502 99/18722 1.53046125330517e-12 7.78012500856015e-11 TYROBP/FCGR2B/NCKAP1L/HLA-B/ICAM1/LGALS9/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/HAVCR2/SPI1/SYK/ARRB2/HLA-E/CLEC7A/STX7/LAMP1 20 GO:0071219 cellular response to molecule of bacterial origin 29/502 221/18722 1.6246683164649e-12 8.16925612170286e-11 MRC1/CD14/MEF2C/CCL2/CD68/CCL3/LY96/FCGR2B/CD36/ICAM1/TLR4/TNFRSF1B/CD86/HAVCR2/SPI1/ZFP36/ADAM9/ABCA1/MTDH/LYN/SGMS1/SIRPA/PYCARD/LY86/XBP1/VIM/TSPO/TGFB1/LITAF 29 GO:0002285 lymphocyte activation involved in immune response 27/502 194/18722 2.35745336794611e-12 1.16808562117076e-10 CD28/CR1/FCER1G/FCGR2B/CD74/NCKAP1L/ICAM1/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-DRA/HLA-DRB1/CD86/HAVCR2/SPI1/PTGER4/LCP1/CD81/FGL2/XBP1/LGALS1/LAMP1/TGFB1/APBB1IP/STAT3/NFKBIZ 27 GO:0071222 cellular response to lipopolysaccharide 28/502 209/18722 2.37354190207634e-12 1.16808562117076e-10 MRC1/CD14/MEF2C/CCL2/CD68/CCL3/LY96/CD36/ICAM1/TLR4/TNFRSF1B/CD86/HAVCR2/SPI1/ZFP36/ADAM9/ABCA1/MTDH/LYN/SGMS1/SIRPA/PYCARD/LY86/XBP1/VIM/TSPO/TGFB1/LITAF 28 GO:0045639 positive regulation of myeloid cell differentiation 20/502 103/18722 3.33414246732875e-12 1.62355190040661e-10 CD4/RUNX1/TYROBP/CD74/CCR1/NCKAP1L/HLA-DRB1/ZFP36L1/RB1/HSPA1A/ISG15/FOS/FOXO3/TGFB1/EVI2B/STAT1/STAT3/HIF1A/JUN/ATP6AP1 20 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 25/502 168/18722 3.42052936293438e-12 1.648267586764e-10 MEF2C/CD4/CD28/CR1/FCGR2B/NCKAP1L/HLA-B/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HAVCR2/HLA-E/CLEC7A/CD81/TNFSF13B/WAS/STX7/TGFB1/PTPN6/AHR/NFKBIZ 25 GO:0001910 regulation of leukocyte mediated cytotoxicity 18/502 82/18722 4.54820091686263e-12 2.16906983932026e-10 TYROBP/FCGR2B/NCKAP1L/HLA-B/ICAM1/LGALS9/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/HAVCR2/SPI1/ARRB2/HLA-E/STX7/LAMP1 18 GO:0050727 regulation of inflammatory response 38/502 386/18722 5.01289254214317e-12 2.36256182175176e-10 IGF1/CD28/CCL3/FCGR2B/TMSB4X/APOE/TLR4/TLR7/ALOX5AP/CTSC/PTPRC/TNFRSF1B/HLA-DRB1/METRNL/RB1/PIK3AP1/NEAT1/SYK/ZFP36/PTGER4/NINJ1/HLA-E/ALOX5/GRN/LYN/CD81/JAK2/SIRPA/PYCARD/GPX1/ACP5/TNFRSF1A/KLF4/NCF1/NUPR1/GPSM3/MGST2/NFKBIZ 38 GO:0051250 negative regulation of lymphocyte activation 24/502 157/18722 5.15820890611603e-12 2.36256182175176e-10 VSIG4/CR1/RUNX1/TYROBP/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/SAMSN1/LGALS9/HLA-DRB1/CD86/HAVCR2/PAG1/LST1/PRNP/LYN/FGL2/TNFRSF14/ATM/PTPN6/DUSP3/PRKAR1A 24 GO:1902107 positive regulation of leukocyte differentiation 24/502 157/18722 5.15820890611603e-12 2.36256182175176e-10 CD4/GAS6/CR1/RUNX1/TYROBP/CD74/CCR1/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/ZFP36L1/CD86/RB1/SYK/FOS/XBP1/TGFBR2/TGFB1/EVI2B/JUN/ATP6AP1/NFKBIZ 24 GO:1903708 positive regulation of hemopoiesis 24/502 157/18722 5.15820890611603e-12 2.36256182175176e-10 CD4/GAS6/CR1/RUNX1/TYROBP/CD74/CCR1/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/ZFP36L1/CD86/RB1/SYK/FOS/XBP1/TGFBR2/TGFB1/EVI2B/JUN/ATP6AP1/NFKBIZ 24 GO:0070374 positive regulation of ERK1 and ERK2 cascade 28/502 217/18722 5.99122174486414e-12 2.71719527370015e-10 CSF1R/CCL2/IGF1/CD4/GAS6/CCL3/PDGFC/APOE/CD74/CD36/GPNMB/CCR1/ICAM1/TLR4/LGALS9/PTPRC/CCL4/HLA-DRB1/HAVCR2/C5AR1/ARRB2/NRP1/PYCARD/CD44/TGFB1/GNAI2/LRP1/ATP6AP1 28 GO:0002832 negative regulation of response to biotic stimulus 20/502 108/18722 8.3794137083134e-12 3.76341435093765e-10 VSIG4/A2M/CR1/HLA-B/IFI16/LGALS9/HLA-A/HAVCR2/SERPING1/SAMHD1/ARRB2/HLA-E/GRN/PARP14/ISG15/FGL2/OAS1/AHR/STAT2/ADAR 20 GO:0002573 myeloid leukocyte differentiation 27/502 208/18722 1.24846403788865e-11 5.55326407622396e-10 C1QC/CSF1R/CD4/RUNX1/TYROBP/CCL3/MAFB/CD74/CCR1/TLR4/IFI16/HLA-DRB1/ZFP36L1/RB1/RBPJ/SPI1/LYN/CD81/FOS/JUNB/TGFBR2/TGFB1/EVI2B/JUN/CITED2/ATP6AP1/PIK3R1 27 GO:0050671 positive regulation of lymphocyte proliferation 22/502 137/18722 1.47234575094347e-11 6.48673470844239e-10 MEF2C/IGF1/CD209/CD28/AIF1/CD74/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-A/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/CD81/TNFSF13B/PYCARD/TGFBR2 22 GO:0032635 interleukin-6 production 24/502 165/18722 1.5317960661156e-11 6.62251271201006e-10 GAS6/TYROBP/AIF1/CD84/CD74/CD36/NCKAP1L/HLA-B/TLR4/TLR7/CYBA/LGALS9/POU2F2/HAVCR2/SYK/ARRB2/KLF2/CLEC7A/SIRPA/PYCARD/XBP1/IFIH1/PTPN6/STAT3 24 GO:0032675 regulation of interleukin-6 production 24/502 165/18722 1.5317960661156e-11 6.62251271201006e-10 GAS6/TYROBP/AIF1/CD84/CD74/CD36/NCKAP1L/HLA-B/TLR4/TLR7/CYBA/LGALS9/POU2F2/HAVCR2/SYK/ARRB2/KLF2/CLEC7A/SIRPA/PYCARD/XBP1/IFIH1/PTPN6/STAT3 24 GO:0032946 positive regulation of mononuclear cell proliferation 22/502 138/18722 1.70859250903947e-11 7.3184712470524e-10 MEF2C/IGF1/CD209/CD28/AIF1/CD74/NCKAP1L/TLR4/LGALS9/HLA-DMB/PTPRC/HLA-A/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/CD81/TNFSF13B/PYCARD/TGFBR2 22 GO:0043523 regulation of neuron apoptotic process 27/502 212/18722 1.95726091983836e-11 8.30668716988278e-10 MEF2C/CCL2/TYROBP/CCL3/LGMN/APOE/NAIP/CTSZ/ITGAM/NR4A2/C5AR1/ARRB2/GRN/PRNP/NRP1/JAK2/SOD2/CPEB4/BTG2/SNX6/FOXO3/PPT1/MCL1/NUPR1/HIF1A/JUN/LRP1 27 GO:0031349 positive regulation of defense response 31/502 278/18722 2.06906981025315e-11 8.7013790383919e-10 MEF2C/CD28/TYROBP/CCL3/TLR4/TLR7/IFI16/ALOX5AP/CTSC/CYBA/HAVCR2/NEAT1/SPI1/SYK/PTGER4/NINJ1/HLA-E/GRN/LYN/CLEC7A/CD81/PARP9/JAK2/PYCARD/PLSCR1/TNFRSF1A/LAMP1/NUPR1/GPSM3/MGST2/NFKBIZ 31 GO:0042102 positive regulation of T cell proliferation 19/502 101/18722 2.09445621402102e-11 8.72878778924438e-10 IGF1/CD209/CD28/AIF1/NCKAP1L/LGALS9/HLA-DMB/PTPRC/HLA-A/CD86/HAVCR2/SYK/HLA-DPA1/HLA-E/HLA-DPB1/CD81/TNFSF13B/PYCARD/TGFBR2 19 GO:0034340 response to type I interferon 15/502 58/18722 2.23145853483428e-11 9.21672069834231e-10 IFI27/IFIT1/IFITM2/OAS2/MX1/IFITM3/SAMHD1/ISG15/OAS1/STAT1/PTPN6/SP100/STAT2/IFNAR1/ADAR 15 GO:0051402 neuron apoptotic process 29/502 246/18722 2.39325194245522e-11 9.78085113637225e-10 MEF2C/CCL2/TYROBP/CCL3/LGMN/APOE/NAIP/CTSZ/ITGAM/RB1/NR4A2/C5AR1/ARRB2/GRN/PRNP/NRP1/JAK2/SOD2/CPEB4/BTG2/GPX1/SNX6/FOXO3/PPT1/MCL1/NUPR1/HIF1A/JUN/LRP1 29 GO:0050900 leukocyte migration 36/502 369/18722 2.41032647978045e-11 9.78085113637225e-10 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/FCER1G/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/ITGB2/ICAM1/LGALS9/CCL4/CXCL16/SPI1/SYK/C5AR1/PTGER4/NINJ1/ALOX5/SELPLG/PECAM1/LYN/CD81/PREX1/TNFRSF14/SIRPA/PYCARD/DUSP1/MSN/GPSM3/EPS8/ADAM10 36 GO:0030098 lymphocyte differentiation 36/502 374/18722 3.54190147443089e-11 1.42476836701889e-09 CD4/GAS6/CD28/CR1/FCER1G/RUNX1/FCGR2B/MAFB/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/B2M/HLA-DRB1/ZFP36L1/KLF6/CD86/RSAD2/RBPJ/SPI1/SYK/PTGER4/PREX1/FGL2/TNFSF13B/ATM/EGR1/XBP1/TGFBR2/ZFP36L2/LGALS1/PTPN6/STAT3/NFKBIZ/PIK3R1 36 GO:0018108 peptidyl-tyrosine phosphorylation 36/502 375/18722 3.82203867782111e-11 1.52420266582763e-09 CSF1R/IGF1/CD4/ENPP2/GAS6/PDGFC/CD74/CD36/SAMSN1/ITGB2/ICAM1/FCGR1A/PTPRC/PEAK1/SYK/ARRB2/PRNP/PARP14/PECAM1/NRP1/LYN/CLEC7A/CD81/RAP2B/EHD4/PARP9/JAK2/TNFRSF14/IQGAP1/SNX6/CD44/TNFRSF1A/TGFB1/NCF1/PTPN6/ABI1 36 GO:0018212 peptidyl-tyrosine modification 36/502 378/18722 4.79442291812788e-11 1.89564106147518e-09 CSF1R/IGF1/CD4/ENPP2/GAS6/PDGFC/CD74/CD36/SAMSN1/ITGB2/ICAM1/FCGR1A/PTPRC/PEAK1/SYK/ARRB2/PRNP/PARP14/PECAM1/NRP1/LYN/CLEC7A/CD81/RAP2B/EHD4/PARP9/JAK2/TNFRSF14/IQGAP1/SNX6/CD44/TNFRSF1A/TGFB1/NCF1/PTPN6/ABI1 36 GO:0071357 cellular response to type I interferon 14/502 52/18722 5.76830723140601e-11 2.26137197054951e-09 IFI27/IFIT1/IFITM2/OAS2/IFITM3/SAMHD1/ISG15/OAS1/STAT1/PTPN6/SP100/STAT2/IFNAR1/ADAR 14 GO:0030218 erythrocyte differentiation 20/502 120/18722 6.24383499307018e-11 2.427225267054e-09 MAFB/NCKAP1L/B2M/ZFP36L1/RB1/SPI1/ZFP36/KLF2/HSPA1A/LYN/ISG15/JAK2/SLC11A2/FOXO3/STAT1/STAT3/HIF1A/CITED2/ADAR/KMT2E 20 GO:0006909 phagocytosis 32/502 308/18722 6.30592971197313e-11 2.43093590396564e-09 CD14/C2/CCL2/GAS6/FCER1G/CD93/TYROBP/AIF1/FCGR2B/CD36/MSR1/NCKAP1L/ITGB2/NCF4/FCGR1A/TLR4/CYBA/PTPRC/ITGAM/SYK/ABCA1/CD302/PECAM1/LYN/CLEC7A/SIRPA/PYCARD/PLSCR1/NCF2/COLEC12/LRP1/GSN 32 GO:0002399 MHC class II protein complex assembly 9/502 16/18722 6.45945693533132e-11 2.44929899859366e-09 HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1 9 GO:0002503 peptide antigen assembly with MHC class II protein complex 9/502 16/18722 6.45945693533132e-11 2.44929899859366e-09 HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1 9 GO:0042554 superoxide anion generation 13/502 44/18722 7.71357860273359e-11 2.90105809888175e-09 CYBB/TYROBP/ITGB2/NCF4/CYBA/ITGAM/SYK/CLEC7A/NCF2/ACP5/TGFB1/NCF1/GNAI2 13 GO:0002704 negative regulation of leukocyte mediated immunity 15/502 63/18722 8.09786392622742e-11 3.02102568731678e-09 CR1/CD84/FCGR2B/NCKAP1L/BST2/HLA-B/LGALS9/PTPRC/HLA-A/HAVCR2/SPI1/ARRB2/HLA-E/PTPN6/AHR 15 GO:0006801 superoxide metabolic process 16/502 74/18722 9.04507898881172e-11 3.34740283217944e-09 CYBB/TYROBP/CD36/ITGB2/NCF4/CYBA/ITGAM/SYK/CLEC7A/PREX1/SOD2/NCF2/ACP5/TGFB1/NCF1/GNAI2 16 GO:0071674 mononuclear cell migration 25/502 196/18722 1.06487777882322e-10 3.90962270225095e-09 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CCR1/ICAM1/LGALS9/CCL4/CXCL16/SPI1/C5AR1/ALOX5/PECAM1/LYN/TNFRSF14/SIRPA/PYCARD/DUSP1/MSN/EPS8/ADAM10 25 GO:0001909 leukocyte mediated cytotoxicity 20/502 124/18722 1.15350513499169e-10 4.20166516100124e-09 TYROBP/FCGR2B/NCKAP1L/HLA-B/ICAM1/CTSC/LGALS9/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/HAVCR2/SPI1/ARRB2/HLA-E/STX7/LAMP1/PTPN6 20 GO:0002706 regulation of lymphocyte mediated immunity 23/502 168/18722 1.42715716693713e-10 5.15783519863372e-09 CD28/CR1/FCGR2B/NCKAP1L/HLA-B/LGALS9/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HAVCR2/ARRB2/HLA-E/CD81/WAS/STX7/LAMP1/TGFB1/PTPN6/AHR 23 GO:0001818 negative regulation of cytokine production 34/502 357/18722 1.6812082655216e-10 6.02889103589376e-09 VSIG4/IGF1/GAS6/CR1/CMKLR1/TYROBP/CD84/FCGR2B/TMSB4X/GPNMB/LAPTM5/NCKAP1L/BST2/TLR4/LGALS9/SRGN/PTPRC/HLA-DRB1/HAVCR2/ZFP36/ARRB2/PTGER4/KLF2/PRNP/OAS1/SIRPA/PYCARD/TSPO/ACP5/KLF4/REL/TGFB1/PTPN6/ADCY7 34 GO:0001774 microglial cell activation 13/502 47/18722 1.94203585843444e-10 6.85790677947918e-09 C1QA/TYROBP/CCL3/AIF1/ITGB2/CTSC/PTPRC/ITGAM/C5AR1/GRN/NAMPT/JAK2/IFNGR2 13 GO:0045646 regulation of erythrocyte differentiation 13/502 47/18722 1.94203585843444e-10 6.85790677947918e-09 MAFB/NCKAP1L/B2M/ZFP36L1/SPI1/ZFP36/HSPA1A/LYN/ISG15/FOXO3/STAT1/STAT3/HIF1A 13 GO:0071675 regulation of mononuclear cell migration 19/502 115/18722 2.20179880038223e-10 7.71630397770318e-09 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CCR1/LGALS9/CCL4/SPI1/C5AR1/LYN/TNFRSF14/PYCARD/DUSP1/MSN/ADAM10 19 GO:0034612 response to tumor necrosis factor 28/502 253/18722 2.35591184411045e-10 8.19432194801123e-09 CD14/CCL2/GAS6/CCL3/TMSB4X/LAPTM5/ICAM1/CYBA/TNFRSF1B/CCL4/ZFP36L1/CXCL16/SYK/ZFP36/ADAM9/KLF2/HSPA1A/ASAH1/TNFSF13B/JAK2/TNFRSF14/SGMS1/PYCARD/ZFP36L2/FOXO3/TNFRSF1A/STAT1/ADAM10 28 GO:0034101 erythrocyte homeostasis 20/502 129/18722 2.4004353802728e-10 8.28687617100147e-09 MAFB/NCKAP1L/B2M/ZFP36L1/RB1/SPI1/ZFP36/KLF2/HSPA1A/LYN/ISG15/JAK2/SLC11A2/FOXO3/STAT1/STAT3/HIF1A/CITED2/ADAR/KMT2E 20 GO:0002501 peptide antigen assembly with MHC protein complex 9/502 18/18722 2.61681821364174e-10 8.96696374541235e-09 HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1 9 GO:0072593 reactive oxygen species metabolic process 27/502 239/18722 3.11850908858561e-10 1.06075169439684e-08 CYBB/TYROBP/CD36/ITGB2/NCF4/TLR4/CYBA/ITGAM/SYK/ALOX5/CLEC7A/PREX1/PDK4/SOD2/TGFBR2/GPX1/NCF2/FOXO3/TSPO/ACP5/TGFB1/NCF1/STAT3/GNAI2/HIF1A/SESN1/PRCP 27 GO:0071346 cellular response to interferon-gamma 19/502 118/18722 3.47833700246877e-10 1.17450999805989e-08 MRC1/CCL2/CCL3/AIF1/ICAM1/TLR4/LGALS9/CCL4/HLA-DPA1/PARP14/PARP9/JAK2/SIRPA/VIM/IFNGR2/ACTR2/WAS/STAT1/SP100 19 GO:0060337 type I interferon signaling pathway 13/502 50/18722 4.55173719551694e-10 1.52582146858416e-08 IFI27/IFITM2/OAS2/IFITM3/SAMHD1/ISG15/OAS1/STAT1/PTPN6/SP100/STAT2/IFNAR1/ADAR 13 GO:0002761 regulation of myeloid leukocyte differentiation 19/502 120/18722 4.68001819921445e-10 1.55753699205511e-08 C1QC/CD4/RUNX1/TYROBP/CCL3/MAFB/CD74/CCR1/TLR4/HLA-DRB1/ZFP36L1/RB1/LYN/FOS/TGFB1/EVI2B/JUN/ATP6AP1/PIK3R1 19 GO:0002685 regulation of leukocyte migration 25/502 210/18722 4.71441400652896e-10 1.55777708530021e-08 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/ICAM1/LGALS9/CCL4/SPI1/C5AR1/PTGER4/LYN/CD81/TNFRSF14/PYCARD/DUSP1/MSN/GPSM3/ADAM10 25 GO:0002396 MHC protein complex assembly 9/502 19/18722 4.85427855143046e-10 1.59261649495868e-08 HLA-DMB/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1 9 GO:0002768 immune response-regulating cell surface receptor signaling pathway 31/502 315/18722 4.90132850836997e-10 1.59672856899433e-08 MEF2C/C3AR1/CD28/CR1/CMKLR1/FCER1G/TYROBP/FCGR2B/LAPTM5/NCKAP1L/PTPRC/HLA-A/FCGR1B/HLA-DRB1/LCP2/HLA-DQB1/FPR3/SYK/C5AR1/HLA-DPB1/PRNP/FPR1/LYN/CLEC7A/CD81/PLSCR1/CMTM3/PTPN6/DUSP3/MAP3K1/NFKBIZ 31 GO:0032722 positive regulation of chemokine production 15/502 71/18722 4.98009618510319e-10 1.61104370295716e-08 CSF1R/AIF1/CD84/CD74/TLR4/TLR7/LGALS9/HAVCR2/SYK/CLEC7A/OAS1/PYCARD/EGR1/HIF1A/LRP1 15 GO:0050672 negative regulation of lymphocyte proliferation 16/502 83/18722 5.56792786866764e-10 1.78869682780948e-08 VSIG4/CR1/TYROBP/FCGR2B/GPNMB/LGALS9/HLA-DRB1/CD86/HAVCR2/LST1/PRNP/LYN/TNFRSF14/ATM/PTPN6/PRKAR1A 16 GO:0022408 negative regulation of cell-cell adhesion 24/502 196/18722 5.90267508683038e-10 1.88315689321913e-08 VSIG4/CR1/RUNX1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/LGALS9/HLA-DRB1/CD86/HAVCR2/SPI1/PAG1/PRNP/FGL2/JAK2/TNFRSF14/KLF4/FXYD5/TGFB1/PTPN6/DUSP3/PRKAR1A 24 GO:0002688 regulation of leukocyte chemotaxis 19/502 122/18722 6.25785796255997e-10 1.96930958740153e-08 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/LGALS9/CCL4/SPI1/C5AR1/LYN/DUSP1/GPSM3/ADAM10 19 GO:0050868 negative regulation of T cell activation 19/502 122/18722 6.25785796255997e-10 1.96930958740153e-08 VSIG4/CR1/RUNX1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/LGALS9/HLA-DRB1/CD86/HAVCR2/PAG1/PRNP/FGL2/TNFRSF14/PTPN6/DUSP3/PRKAR1A 19 GO:0030595 leukocyte chemotaxis 26/502 230/18722 6.58118071588111e-10 2.05706364808554e-08 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/FCER1G/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/ITGB2/LGALS9/CCL4/CXCL16/SPI1/SYK/C5AR1/NINJ1/ALOX5/LYN/PREX1/DUSP1/GPSM3/ADAM10 26 GO:0032945 negative regulation of mononuclear cell proliferation 16/502 84/18722 6.7103495262606e-10 2.08336086634104e-08 VSIG4/CR1/TYROBP/FCGR2B/GPNMB/LGALS9/HLA-DRB1/CD86/HAVCR2/LST1/PRNP/LYN/TNFRSF14/ATM/PTPN6/PRKAR1A 16 GO:0032642 regulation of chemokine production 17/502 98/18722 9.02061458998495e-10 2.78195753955136e-08 CSF1R/AIF1/CD84/CD74/TLR4/TLR7/LGALS9/HAVCR2/SYK/CLEC7A/OAS1/SIRPA/PYCARD/EGR1/KLF4/HIF1A/LRP1 17 GO:0031343 positive regulation of cell killing 14/502 63/18722 9.30375877470620e-10 2.85027735707224e-08 TYROBP/HLA-B/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/SPI1/SYK/HLA-E/CLEC7A/STX7/LAMP1 14 GO:0032602 chemokine production 17/502 99/18722 1.0624821906957e-09 3.23358066720941e-08 CSF1R/AIF1/CD84/CD74/TLR4/TLR7/LGALS9/HAVCR2/SYK/CLEC7A/OAS1/SIRPA/PYCARD/EGR1/KLF4/HIF1A/LRP1 17 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 7/502 10/18722 1.07000308213736e-09 3.2351857895212e-08 ICAM1/LGALS9/HLA-DMB/HAVCR2/CD81/FGL2/APBB1IP 7 GO:0002440 production of molecular mediator of immune response 30/502 308/18722 1.20158593416858e-09 3.60943930614534e-08 CD28/CR1/FCGR2B/CD74/CD36/LAPTM5/BST2/TLR4/HLA-DMB/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/CD86/RSAD2/HLA-DQA1/HLA-DQB1/HLA-DMA/SAMHD1/HLA-DPA1/HLA-E/HLA-DPB1/CLEC7A/CD81/TNFRSF14/XBP1/TGFB1/TMBIM6 30 GO:1903038 negative regulation of leukocyte cell-cell adhesion 20/502 141/18722 1.21316224589968e-09 3.62070229002059e-08 VSIG4/CR1/RUNX1/FCGR2B/CD74/GPNMB/LAPTM5/NCKAP1L/LGALS9/HLA-DRB1/CD86/HAVCR2/PAG1/PRNP/FGL2/TNFRSF14/KLF4/PTPN6/DUSP3/PRKAR1A 20 GO:0002429 immune response-activating cell surface receptor signaling pathway 29/502 291/18722 1.34345191282721e-09 3.9584767826361e-08 MEF2C/C3AR1/CD28/CR1/CMKLR1/FCER1G/TYROBP/FCGR2B/LAPTM5/NCKAP1L/PTPRC/HLA-A/HLA-DRB1/LCP2/HLA-DQB1/FPR3/SYK/C5AR1/HLA-DPB1/PRNP/FPR1/LYN/CLEC7A/CD81/PLSCR1/CMTM3/PTPN6/DUSP3/NFKBIZ 29 GO:0002757 immune response-activating signal transduction 29/502 291/18722 1.34345191282721e-09 3.9584767826361e-08 MEF2C/C3AR1/CD28/CR1/CMKLR1/FCER1G/TYROBP/FCGR2B/LAPTM5/NCKAP1L/PTPRC/HLA-A/HLA-DRB1/LCP2/HLA-DQB1/FPR3/SYK/C5AR1/HLA-DPB1/PRNP/FPR1/LYN/CLEC7A/CD81/PLSCR1/CMTM3/PTPN6/DUSP3/NFKBIZ 29 GO:0060326 cell chemotaxis 30/502 310/18722 1.40188385081062e-09 4.1011863722459e-08 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/FCER1G/CCL3/AIF1/LGMN/TMSB4X/CD74/CCR1/NCKAP1L/ITGB2/LGALS9/CCL4/CXCL16/SPI1/SYK/C5AR1/ARRB2/NINJ1/ALOX5/NRP1/LYN/PREX1/DUSP1/NR4A1/GPSM3/ADAM10 30 GO:0002286 T cell activation involved in immune response 18/502 114/18722 1.40961658708841e-09 4.1011863722459e-08 FCER1G/FCGR2B/CD74/NCKAP1L/ICAM1/LGALS9/HLA-DMB/HLA-DRA/HLA-DRB1/CD86/HAVCR2/PTGER4/LCP1/CD81/FGL2/APBB1IP/STAT3/NFKBIZ 18 GO:0030217 T cell differentiation 27/502 257/18722 1.58163415987849e-09 4.57289976474868e-08 CD4/CD28/CR1/FCER1G/RUNX1/MAFB/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/B2M/HLA-DRB1/ZFP36L1/CD86/RSAD2/SPI1/SYK/PTGER4/PREX1/FGL2/EGR1/XBP1/TGFBR2/ZFP36L2/STAT3/NFKBIZ 27 GO:0016064 immunoglobulin mediated immune response 24/502 207/18722 1.80592191124393e-09 5.18894084559902e-08 C1QA/C1QB/C1QC/C2/CD28/CR1/FCER1G/FCGR2B/CD74/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/SERPING1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CD81/TGFB1/PTPN6 24 GO:0070664 negative regulation of leukocyte proliferation 16/502 90/18722 1.94492990832359e-09 5.5538554048796e-08 VSIG4/CR1/TYROBP/FCGR2B/GPNMB/LGALS9/HLA-DRB1/CD86/HAVCR2/LST1/PRNP/LYN/TNFRSF14/ATM/PTPN6/PRKAR1A 16 GO:0019079 viral genome replication 19/502 131/18722 2.15421032886493e-09 6.11372820940439e-08 CCL2/CD209/GAS6/CD28/IFI27/BST2/IFI16/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ISG15/OAS1/PLSCR1/IFIH1/DDX5/ADAR 19 GO:0046635 positive regulation of alpha-beta T cell activation 14/502 67/18722 2.20743361456835e-09 6.22657798841049e-08 CD28/RUNX1/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-A/HLA-DRB1/CD86/SYK/HLA-E/CD81/TGFBR2/NFKBIZ 14 GO:0019724 B cell mediated immunity 24/502 210/18722 2.41677953427854e-09 6.77577098519546e-08 C1QA/C1QB/C1QC/C2/CD28/CR1/FCER1G/FCGR2B/CD74/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/SERPING1/HLA-DMA/HLA-DPA1/HLA-E/HLA-DPB1/CD81/TGFB1/PTPN6 24 GO:0002700 regulation of production of molecular mediator of immune response 21/502 164/18722 3.1303176442307e-09 8.72340326639229e-08 CD28/CR1/FCGR2B/CD74/CD36/LAPTM5/BST2/TLR4/PTPRC/TNFRSF1B/B2M/HLA-A/CD86/RSAD2/HLA-E/CLEC7A/CD81/TNFRSF14/XBP1/TGFB1/TMBIM6 21 GO:0002763 positive regulation of myeloid leukocyte differentiation 13/502 58/18722 3.3276413884455e-09 9.21776590595741e-08 CD4/RUNX1/TYROBP/CD74/CCR1/HLA-DRB1/ZFP36L1/RB1/FOS/TGFB1/EVI2B/JUN/ATP6AP1 13 GO:0002687 positive regulation of leukocyte migration 19/502 135/18722 3.60553942045225e-09 9.9281103327453e-08 CSF1R/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/ICAM1/LGALS9/CCL4/SPI1/C5AR1/TNFRSF14/PYCARD/GPSM3/ADAM10 19 GO:0002690 positive regulation of leukocyte chemotaxis 16/502 94/18722 3.76728963659935e-09 1.03121194431412e-07 CSF1R/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/LGALS9/CCL4/SPI1/C5AR1/GPSM3/ADAM10 16 GO:0002532 production of molecular mediator involved in inflammatory response 16/502 95/18722 4.41990955852103e-09 1.20273538927755e-07 CD36/TLR4/ALOX5AP/PLD3/SYK/ALOX5/GRN/LYN/CLEC7A/SIRPA/PYCARD/NCF1/GPSM3/STAT3/ADCY7/HIF1A 16 GO:0002456 T cell mediated immunity 17/502 109/18722 4.90652961161872e-09 1.32734537914317e-07 FCGR2B/NCKAP1L/HLA-B/ICAM1/CTSC/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CD81/WAS/STX7/AHR 17 GO:0048872 homeostasis of number of cells 27/502 272/18722 5.46157097269763e-09 1.46890856509879e-07 MEF2C/MAFB/CD74/NCKAP1L/LGALS9/B2M/ZFP36L1/RB1/SPI1/ZFP36/KLF2/HSPA1A/LYN/ISG15/TNFSF13B/JAK2/SLC11A2/TSC22D3/LIPA/FOXO3/STAT1/STAT3/HIF1A/CITED2/SKIL/ADAR/KMT2E 27 GO:1901216 positive regulation of neuron death 16/502 97/18722 6.04587199029427e-09 1.61133987768377e-07 C1QA/TYROBP/CCL3/FCGR2B/CTSZ/ITGB2/TLR4/ITGAM/GRN/PRNP/FOS/EGR1/FOXO3/MCL1/NUPR1/JUN 16 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 9/502 24/18722 6.09564372232293e-09 1.61133987768377e-07 FCGR2B/NCKAP1L/HLA-B/LGALS9/PTPRC/HLA-A/HAVCR2/ARRB2/HLA-E 9 GO:0032928 regulation of superoxide anion generation 9/502 24/18722 6.09564372232293e-09 1.61133987768377e-07 TYROBP/ITGB2/CYBA/ITGAM/SYK/CLEC7A/ACP5/TGFB1/GNAI2 9 GO:0002709 regulation of T cell mediated immunity 15/502 85/18722 6.93668068465042e-09 1.81294264673406e-07 FCGR2B/NCKAP1L/HLA-B/PTPRC/TNFRSF1B/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CD81/WAS/STX7/AHR 15 GO:0045069 regulation of viral genome replication 15/502 85/18722 6.93668068465042e-09 1.81294264673406e-07 CD28/BST2/IFI16/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ISG15/OAS1/PLSCR1/IFIH1/DDX5/ADAR 15 GO:0001906 cell killing 22/502 188/18722 7.24568114619469e-09 1.88306297653352e-07 TYROBP/FCGR2B/NCKAP1L/HLA-B/ICAM1/CTSC/LGALS9/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/HAVCR2/SPI1/SYK/ARRB2/HLA-E/CLEC7A/STX7/LAMP1/PTPN6 22 GO:0002821 positive regulation of adaptive immune response 17/502 112/18722 7.50213467236644e-09 1.91474209519985e-07 CD4/CD28/HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CLEC7A/CD81/TNFSF13B/PYCARD/STX7/TGFB1/NFKBIZ 17 GO:0032609 interferon-gamma production 17/502 112/18722 7.50213467236644e-09 1.91474209519985e-07 CD14/GAS6/CR1/LAPTM5/TLR4/TLR7/LGALS9/HLA-A/HLA-DRB1/HAVCR2/HLA-DPA1/HLA-DPB1/PRNP/CLEC7A/ISG15/SIRPA/PYCARD 17 GO:0032649 regulation of interferon-gamma production 17/502 112/18722 7.50213467236644e-09 1.91474209519985e-07 CD14/GAS6/CR1/LAPTM5/TLR4/TLR7/LGALS9/HLA-A/HLA-DRB1/HAVCR2/HLA-DPA1/HLA-DPB1/PRNP/CLEC7A/ISG15/SIRPA/PYCARD 17 GO:0050921 positive regulation of chemotaxis 19/502 141/18722 7.53314010649312e-09 1.91474209519985e-07 CSF1R/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/TMSB4X/CD74/CCR1/NCKAP1L/LGALS9/CCL4/SPI1/C5AR1/NRP1/TGFB1/GPSM3/ADAM10 19 GO:0042113 B cell activation 30/502 334/18722 8.04795224773149e-09 2.0344167813118e-07 MEF2C/CD28/CR1/TYROBP/FCGR2B/CD74/LAPTM5/NCKAP1L/BST2/SAMSN1/TLR4/PTPRC/ZFP36L1/KLF6/CD86/RBPJ/SPI1/SYK/LYN/CD81/TNFSF13B/ATM/XBP1/SKAP2/ZFP36L2/LGALS1/TGFB1/PTPN6/AHR/PIK3R1 30 GO:0002262 myeloid cell homeostasis 20/502 157/18722 8.14011366338744e-09 2.04653075037121e-07 MAFB/NCKAP1L/B2M/ZFP36L1/RB1/SPI1/ZFP36/KLF2/HSPA1A/LYN/ISG15/JAK2/SLC11A2/FOXO3/STAT1/STAT3/HIF1A/CITED2/ADAR/KMT2E 20 GO:1901215 negative regulation of neuron death 23/502 208/18722 9.84152389605702e-09 2.46091294827891e-07 MEF2C/CCL2/LGMN/APOE/NAIP/GPNMB/TNFRSF1B/NR4A2/C5AR1/ARRB2/GRN/NRP1/JAK2/SOD2/CPEB4/BTG2/ATG7/SNX6/REL/PPT1/STAT3/HIF1A/LRP1 23 GO:0071496 cellular response to external stimulus 29/502 320/18722 1.17489214552913e-08 2.92207046517084e-07 FOLR2/CD68/GAS6/AIF1/ICAM1/TLR4/TLR7/IFI16/CYBA/PTPRC/NR4A2/PTGER4/LYN/FOS/NAMPT/PDK4/CPEB4/XBP1/ATG7/GLUL/UCP2/ENG/FOXO3/TNFRSF1A/LAMP2/SESN1/USF2/JUN/MAP3K1 29 GO:0002707 negative regulation of lymphocyte mediated immunity 12/502 53/18722 1.18999525679564e-08 2.94380644809445e-07 CR1/FCGR2B/NCKAP1L/HLA-B/LGALS9/PTPRC/HLA-A/HAVCR2/ARRB2/HLA-E/PTPN6/AHR 12 GO:0036230 granulocyte activation 11/502 43/18722 1.22278142743355e-08 3.00882281026999e-07 FCER1G/TYROBP/CCL3/FCGR2B/ITGB2/ITGAM/SPI1/SYK/GRN/PREX1/KMT2E 11 GO:2000379 positive regulation of reactive oxygen species metabolic process 14/502 76/18722 1.24294065469829e-08 3.04224522149964e-07 TYROBP/CD36/ITGB2/TLR4/CYBA/ITGAM/SYK/CLEC7A/SOD2/TGFBR2/FOXO3/TSPO/TGFB1/GNAI2 14 GO:0071356 cellular response to tumor necrosis factor 24/502 229/18722 1.35507136093042e-08 3.299242166139e-07 CCL2/GAS6/CCL3/TMSB4X/LAPTM5/ICAM1/CYBA/TNFRSF1B/CCL4/ZFP36L1/SYK/ZFP36/KLF2/HSPA1A/ASAH1/TNFSF13B/JAK2/TNFRSF14/SGMS1/PYCARD/ZFP36L2/FOXO3/TNFRSF1A/STAT1 24 GO:0050766 positive regulation of phagocytosis 13/502 66/18722 1.77309181577855e-08 4.2944098114092e-07 C2/CCL2/GAS6/FCER1G/FCGR2B/CD36/NCKAP1L/CYBA/PTPRC/CLEC7A/SIRPA/PYCARD/LRP1 13 GO:0050864 regulation of B cell activation 22/502 198/18722 1.89034676321314e-08 4.55455423261667e-07 MEF2C/CD28/CR1/TYROBP/FCGR2B/CD74/LAPTM5/NCKAP1L/SAMSN1/TLR4/PTPRC/ZFP36L1/SYK/LYN/CD81/TNFSF13B/ATM/XBP1/ZFP36L2/TGFB1/PTPN6/AHR 22 GO:0002705 positive regulation of leukocyte mediated immunity 18/502 134/18722 1.96795124782008e-08 4.71696501161434e-07 CD28/TYROBP/ITGB2/HLA-B/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/RSAD2/SPI1/HLA-E/CLEC7A/CD81/STX7/LAMP1/TGFB1 18 GO:1904646 cellular response to amyloid-beta 11/502 45/18722 2.05572385062613e-08 4.90194769742087e-07 IGF1/FCGR2B/LGMN/CD36/ICAM1/TLR4/PRNP/NAMPT/SNX6/FOXO3/LRP1 11 GO:0048525 negative regulation of viral process 15/502 92/18722 2.12722340517021e-08 5.04642844734226e-07 BST2/IFI16/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ZFP36/ISG15/OAS1/PLSCR1/IFIH1/STAT1/GSN 15 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 12/502 56/18722 2.3151678015784e-08 5.43653109142218e-07 TYROBP/HLA-B/PTPRC/HLA-DRA/B2M/ITGAM/HLA-A/HLA-DRB1/SPI1/HLA-E/STX7/LAMP1 12 GO:0045071 negative regulation of viral genome replication 12/502 56/18722 2.3151678015784e-08 5.43653109142218e-07 BST2/IFI16/IFIT1/IFITM2/RSAD2/OAS2/MX1/IFITM3/ISG15/OAS1/PLSCR1/IFIH1 12 GO:0042119 neutrophil activation 10/502 36/18722 2.38730644768856e-08 5.54616947653191e-07 FCER1G/TYROBP/FCGR2B/ITGB2/ITGAM/SPI1/SYK/GRN/PREX1/KMT2E 10 GO:0090322 regulation of superoxide metabolic process 10/502 36/18722 2.38730644768856e-08 5.54616947653191e-07 TYROBP/CD36/ITGB2/CYBA/ITGAM/SYK/CLEC7A/ACP5/TGFB1/GNAI2 10 GO:0032930 positive regulation of superoxide anion generation 8/502 20/18722 2.39782510874704e-08 5.54616947653191e-07 TYROBP/ITGB2/CYBA/ITGAM/SYK/CLEC7A/TGFB1/GNAI2 8 GO:0002224 toll-like receptor signaling pathway 17/502 121/18722 2.46985777801243e-08 5.66727864203721e-07 CD14/LY96/CTSS/CD36/TLR4/TLR7/CYBA/UNC93B1/RSAD2/PIK3AP1/HAVCR2/ARRB2/NINJ1/LYN/OAS1/RTN4/COLEC12 17 GO:0032755 positive regulation of interleukin-6 production 15/502 93/18722 2.4746871718364e-08 5.66727864203721e-07 TYROBP/AIF1/CD74/CD36/TLR4/TLR7/CYBA/LGALS9/POU2F2/SYK/CLEC7A/PYCARD/XBP1/IFIH1/STAT3 15 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 16/502 107/18722 2.58317294573303e-08 5.88658031869999e-07 CD4/CD28/HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CLEC7A/CD81/TNFSF13B/STX7/TGFB1/NFKBIZ 16 GO:0097529 myeloid leukocyte migration 23/502 220/18722 2.85016127615627e-08 6.46315983504848e-07 CSF1R/CCL2/C3AR1/CMKLR1/FCER1G/CCL3/AIF1/LGMN/CD74/CCR1/NCKAP1L/ITGB2/CCL4/SPI1/SYK/C5AR1/PTGER4/PECAM1/LYN/CD81/PREX1/SIRPA/DUSP1 23 GO:0031342 negative regulation of cell killing 9/502 28/18722 2.92628036520882e-08 6.60340144851513e-07 FCGR2B/NCKAP1L/HLA-B/LGALS9/PTPRC/HLA-A/HAVCR2/ARRB2/HLA-E 9 GO:0050764 regulation of phagocytosis 15/502 95/18722 3.32885417541122e-08 7.47537835701569e-07 C2/CCL2/GAS6/FCER1G/FCGR2B/CD36/NCKAP1L/CYBA/PTPRC/SYK/CLEC7A/SIRPA/PYCARD/PLSCR1/LRP1 15 GO:0032956 regulation of actin cytoskeleton organization 30/502 357/18722 3.66034347891016e-08 8.16865650830657e-07 CSF1R/TMSB4X/PLEK/NCKAP1L/BST2/ICAM1/MTSS1/CCDC88A/PTGER4/NRP1/PREX1/FCHSD2/PYCARD/IQGAP1/ARHGAP18/ACTR2/GPR65/GMFG/CYFIP1/WAS/ARHGDIB/CAPG/CAPZA2/LRP1/RHOB/EPS8/PIK3R1/GSN/TAOK1/AKAP13 30 GO:0050920 regulation of chemotaxis 23/502 223/18722 3.67289354459094e-08 8.16865650830657e-07 CSF1R/CCL2/C3AR1/GAS6/CMKLR1/CCL3/AIF1/LGMN/TMSB4X/CD74/CCR1/NCKAP1L/LGALS9/CCL4/SPI1/C5AR1/NRP1/LYN/DUSP1/TGFB1/GPSM3/DUSP3/ADAM10 23 GO:0035455 response to interferon-alpha 8/502 21/18722 3.78280560201812e-08 8.33298034044562e-07 GAS6/BST2/IFITM2/MX2/IFITM3/IFIT3/IFNAR1/ADAR 8 GO:0046641 positive regulation of alpha-beta T cell proliferation 8/502 21/18722 3.78280560201812e-08 8.33298034044562e-07 CD28/LGALS9/PTPRC/HLA-A/SYK/HLA-E/CD81/TGFBR2 8 GO:0002221 pattern recognition receptor signaling pathway 20/502 172/18722 3.9042647947956e-08 8.55977674915851e-07 CD14/LY96/CTSS/CD36/TLR4/TLR7/CYBA/UNC93B1/RSAD2/PIK3AP1/HAVCR2/ARRB2/NINJ1/HSPA1A/SLC15A3/LYN/OAS1/IFIH1/RTN4/COLEC12 20 GO:1901653 cellular response to peptide 30/502 359/18722 4.1478350358356e-08 9.05088909234693e-07 IGF1/FCGR2B/LGMN/CD36/ICAM1/TLR4/CYBA/MYO5A/ZFP36L1/NR4A2/KLF2/PRNP/LYN/NAMPT/JAK2/PDK4/XBP1/VIM/UCP2/SNX6/FOXO3/CYFIP1/KLF4/NR4A1/STAT1/STAT3/GNAI2/LRP1/PIK3R1/RAB8B 30 GO:2000377 regulation of reactive oxygen species metabolic process 19/502 157/18722 4.47121809967042e-08 9.7107300136504e-07 TYROBP/CD36/ITGB2/TLR4/CYBA/ITGAM/SYK/ALOX5/CLEC7A/SOD2/TGFBR2/FOXO3/TSPO/ACP5/TGFB1/STAT3/GNAI2/HIF1A/PRCP 19 GO:0050729 positive regulation of inflammatory response 18/502 142/18722 4.91989252264711e-08 1.06352443036287e-06 CD28/CCL3/TLR4/TLR7/ALOX5AP/CTSC/NEAT1/PTGER4/NINJ1/HLA-E/GRN/CD81/JAK2/TNFRSF1A/NUPR1/GPSM3/MGST2/NFKBIZ 18 GO:0001913 T cell mediated cytotoxicity 11/502 49/18722 5.35559458258618e-08 1.15232467623459e-06 FCGR2B/NCKAP1L/HLA-B/CTSC/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-E/STX7 11 GO:0001914 regulation of T cell mediated cytotoxicity 10/502 39/18722 5.55468652662121e-08 1.18962869778471e-06 FCGR2B/NCKAP1L/HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-E/STX7 10 GO:0032612 interleukin-1 production 17/502 128/18722 5.78302561053113e-08 1.22716864561087e-06 IGF1/GAS6/TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/HAVCR2/ARRB2/CLEC7A/JAK2/SIRPA/PYCARD/EGR1/ACP5/STAT3 17 GO:0032652 regulation of interleukin-1 production 17/502 128/18722 5.78302561053113e-08 1.22716864561087e-06 IGF1/GAS6/TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/HAVCR2/ARRB2/CLEC7A/JAK2/SIRPA/PYCARD/EGR1/ACP5/STAT3 17 GO:0043524 negative regulation of neuron apoptotic process 18/502 145/18722 6.81912233039927e-08 1.44042282650352e-06 MEF2C/CCL2/LGMN/APOE/NAIP/NR4A2/C5AR1/ARRB2/GRN/NRP1/JAK2/SOD2/CPEB4/BTG2/SNX6/PPT1/HIF1A/LRP1 18 GO:0051651 maintenance of location in cell 22/502 213/18722 7.09465649967664e-08 1.49181277125019e-06 CD4/CCL3/FTL/TMSB4X/APOE/CYBA/SRGN/PTPRC/CCDC88A/MCOLN1/ITPR2/SLC8A1/LYN/VPS13C/FTH1/TSPO/PTPN6/SP100/GAA/CHCHD10/CALM2/GSN 22 GO:0060759 regulation of response to cytokine stimulus 19/502 162/18722 7.43365605341031e-08 1.55602230330661e-06 GAS6/CD74/LAPTM5/TLR4/PTPRC/SYK/SAMHD1/HSPA1A/PARP14/ISG15/PARP9/OAS1/PYCARD/KLF4/IFIH1/PTPN6/HIF1A/STAT2/ADAR 19 GO:0032623 interleukin-2 production 12/502 62/18722 7.73920113742528e-08 1.6054504242928e-06 VSIG4/CD4/CD28/CR1/RUNX1/LAPTM5/PTPRC/CD86/HAVCR2/ZFP36/PRNP/CLEC7A 12 GO:0032663 regulation of interleukin-2 production 12/502 62/18722 7.73920113742528e-08 1.6054504242928e-06 VSIG4/CD4/CD28/CR1/RUNX1/LAPTM5/PTPRC/CD86/HAVCR2/ZFP36/PRNP/CLEC7A 12 GO:0097305 response to alcohol 24/502 253/18722 9.22425023269074e-08 1.90497239180479e-06 CD14/CYBB/CCL3/ICAM1/CYBA/ITPR2/TBXAS1/SPI1/PTGER4/KLF2/ABCA1/FOS/SOD2/TGFBR2/ACTR2/FOXO3/FOSB/TSPO/KLF4/TGFB1/STAT3/ADCY7/AHR/EPS8 24 GO:0002702 positive regulation of production of molecular mediator of immune response 16/502 117/18722 9.37363777633789e-08 1.92721992681507e-06 CD28/CD74/CD36/LAPTM5/TLR4/PTPRC/B2M/HLA-A/CD86/RSAD2/HLA-E/CLEC7A/CD81/TNFRSF14/XBP1/TGFB1 16 GO:0030888 regulation of B cell proliferation 12/502 64/18722 1.1207470139286e-07 2.29406003824501e-06 MEF2C/TYROBP/FCGR2B/CD74/NCKAP1L/TLR4/PTPRC/LYN/CD81/TNFSF13B/ATM/AHR 12 GO:0046634 regulation of alpha-beta T cell activation 15/502 104/18722 1.15330924757277e-07 2.35031214945886e-06 CD28/RUNX1/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-A/HLA-DRB1/CD86/SYK/HLA-E/CD81/TNFRSF14/TGFBR2/NFKBIZ 15 GO:0046596 regulation of viral entry into host cell 10/502 42/18722 1.19607379344455e-07 2.4267707756467e-06 CD4/CD74/LGALS9/HLA-DRB1/IFITM2/IFITM3/TRIM22/LGALS1/TRIM38/GSN 10 GO:0046598 positive regulation of viral entry into host cell 6/502 11/18722 1.48670140347601e-07 2.99020899673045e-06 CD4/CD74/LGALS9/HLA-DRB1/LGALS1/TRIM38 6 GO:0075294 positive regulation by symbiont of entry into host 6/502 11/18722 1.48670140347601e-07 2.99020899673045e-06 CD4/CD74/LGALS9/HLA-DRB1/LGALS1/TRIM38 6 GO:0033674 positive regulation of kinase activity 34/502 467/18722 1.49423951840399e-07 2.99236017841423e-06 CSF1R/IGF1/CD4/GAS6/PDGFC/CD74/NCKAP1L/FCGR1A/TLR4/PTPRC/HLA-DRB1/LCP2/CD86/CCDC88A/SYK/ADAM9/PRNP/LYN/CD81/JAK2/EGR1/IQGAP1/TGFBR2/TGFB1/NCF1/DAZAP2/TAOK3/ABI1/CAB39/RANBP2/CALM2/TAOK1/STK4/AKAP13 34 GO:0055094 response to lipoprotein particle 9/502 34/18722 1.92548904859839e-07 3.83935876673111e-06 CD68/FCER1G/APOE/CD36/ITGB2/TLR4/SYK/ABCA1/CD81 9 GO:0046631 alpha-beta T cell activation 18/502 156/18722 2.10062319293535e-07 4.17059351524417e-06 CD28/RUNX1/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-A/HLA-DRB1/CD86/RSAD2/SYK/PTGER4/HLA-E/CD81/TNFRSF14/TGFBR2/STAT3/NFKBIZ 18 GO:1904645 response to amyloid-beta 11/502 56/18722 2.31034089510395e-07 4.56736623109011e-06 IGF1/FCGR2B/LGMN/CD36/ICAM1/TLR4/PRNP/NAMPT/SNX6/FOXO3/LRP1 11 GO:0045619 regulation of lymphocyte differentiation 19/502 174/18722 2.32296167584232e-07 4.57277477125387e-06 GAS6/CD28/CR1/RUNX1/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/ZFP36L1/CD86/SYK/FGL2/XBP1/TGFBR2/ZFP36L2/PTPN6/NFKBIZ 19 GO:0032611 interleukin-1 beta production 15/502 110/18722 2.45270655269429e-07 4.78743481551214e-06 IGF1/TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/ARRB2/CLEC7A/JAK2/SIRPA/PYCARD/EGR1/ACP5/STAT3 15 GO:0032651 regulation of interleukin-1 beta production 15/502 110/18722 2.45270655269429e-07 4.78743481551214e-06 IGF1/TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/ARRB2/CLEC7A/JAK2/SIRPA/PYCARD/EGR1/ACP5/STAT3 15 GO:0046640 regulation of alpha-beta T cell proliferation 9/502 35/18722 2.53086645147813e-07 4.91923874140245e-06 CD28/LGALS9/PTPRC/HLA-A/SYK/HLA-E/CD81/TNFRSF14/TGFBR2 9 GO:0019883 antigen processing and presentation of endogenous antigen 8/502 26/18722 2.58031925319016e-07 4.99437525743e-06 CD74/HLA-B/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-C/HLA-E 8 GO:0002718 regulation of cytokine production involved in immune response 14/502 96/18722 2.65051933230673e-07 5.10887601302123e-06 CD74/CD36/LAPTM5/BST2/TLR4/TNFRSF1B/B2M/HLA-A/RSAD2/HLA-E/CLEC7A/CD81/TNFRSF14/TGFB1 14 GO:0050728 negative regulation of inflammatory response 19/502 176/18722 2.78023395166104e-07 5.33666483833359e-06 IGF1/FCGR2B/APOE/PTPRC/TNFRSF1B/HLA-DRB1/METRNL/RB1/SYK/ZFP36/PTGER4/ALOX5/GRN/LYN/SIRPA/GPX1/ACP5/TNFRSF1A/KLF4 19 GO:1902563 regulation of neutrophil activation 6/502 12/18722 2.90600983687456e-07 5.55504194437261e-06 FCGR2B/ITGB2/ITGAM/SPI1/SYK/GRN 6 GO:0043300 regulation of leukocyte degranulation 10/502 46/18722 3.0095192419702e-07 5.72923292730623e-06 CD84/FCGR2B/NCKAP1L/ITGB2/LGALS9/ITGAM/SPI1/SYK/LYN/LAMP1 10 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 12/502 70/18722 3.13760601642384e-07 5.94859239015437e-06 CD28/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-DRB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DPA1/HLA-DPB1/TGFB1 12 GO:0071402 cellular response to lipoprotein particle stimulus 9/502 36/18722 3.29491172038121e-07 6.2213312728504e-06 CD68/FCER1G/APOE/CD36/ITGB2/TLR4/SYK/ABCA1/CD81 9 GO:0002367 cytokine production involved in immune response 14/502 98/18722 3.44111664922289e-07 6.47097789402645e-06 CD74/CD36/LAPTM5/BST2/TLR4/TNFRSF1B/B2M/HLA-A/RSAD2/HLA-E/CLEC7A/CD81/TNFRSF14/TGFB1 14 GO:0032970 regulation of actin filament-based process 30/502 396/18722 3.53154260235131e-07 6.61413606416079e-06 CSF1R/TMSB4X/PLEK/NCKAP1L/BST2/ICAM1/MTSS1/CCDC88A/PTGER4/NRP1/PREX1/FCHSD2/PYCARD/IQGAP1/ARHGAP18/ACTR2/GPR65/GMFG/CYFIP1/WAS/ARHGDIB/CAPG/CAPZA2/LRP1/RHOB/EPS8/PIK3R1/GSN/TAOK1/AKAP13 30 GO:0002483 antigen processing and presentation of endogenous peptide antigen 7/502 19/18722 3.64104278771333e-07 6.79171932901688e-06 HLA-B/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-C/HLA-E 7 GO:0097028 dendritic cell differentiation 10/502 47/18722 3.73207937593584e-07 6.93357397312417e-06 TMEM176B/TMEM176A/GAS6/FCGR2B/HLA-B/LGALS9/RBPJ/SPI1/LYN/TGFBR2 10 GO:0007015 actin filament organization 32/502 441/18722 3.76548540896079e-07 6.96765420074104e-06 MARCKS/AIF1/TMSB4X/PLEK/NCKAP1L/ICAM1/MTSS1/MYO5A/CCDC88A/WIPF1/PTGER4/LCP1/NRP1/PREX1/JAK2/FCHSD2/PYCARD/ARHGAP18/ACTR2/GPR65/MYO1F/GMFG/CYFIP1/WAS/TPM3/CAPG/CAPZA2/ABI1/RHOB/EPS8/PIK3R1/GSN 32 GO:0031663 lipopolysaccharide-mediated signaling pathway 11/502 60/18722 4.82686593457301e-07 8.89604853120907e-06 CD14/CCL2/CCL3/LY96/CD36/TLR4/SPI1/MTDH/LYN/LY86/TGFB1 11 GO:0032732 positive regulation of interleukin-1 production 12/502 73/18722 5.04092880818163e-07 9.2537050264477e-06 TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/HAVCR2/CLEC7A/JAK2/PYCARD/EGR1/STAT3 12 GO:0002430 complement receptor mediated signaling pathway 6/502 13/18722 5.27460879595719e-07 9.64440327671855e-06 C3AR1/CR1/CMKLR1/FPR3/C5AR1/FPR1 6 GO:1902903 regulation of supramolecular fiber organization 29/502 382/18722 5.31220129858744e-07 9.67489890049822e-06 TMSB4X/APOE/PLEK/NCKAP1L/ICAM1/MTSS1/RB1/CCDC88A/COLGALT1/PTGER4/HSPA1A/NRP1/PREX1/FCHSD2/PYCARD/ARHGAP18/GPX1/ACTR2/GPR65/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/PIK3R1/GSN/TAOK1/AKAP13 29 GO:0046633 alpha-beta T cell proliferation 9/502 38/18722 5.43940965456807e-07 9.86772904393407e-06 CD28/LGALS9/PTPRC/HLA-A/SYK/HLA-E/CD81/TNFRSF14/TGFBR2 9 GO:0052372 modulation by symbiont of entry into host 10/502 49/18722 5.64496288966176e-07 1.02006243467091e-05 CD4/CD74/LGALS9/HLA-DRB1/IFITM2/IFITM3/TRIM22/LGALS1/TRIM38/GSN 10 GO:0043254 regulation of protein-containing complex assembly 31/502 427/18722 5.67925797470634e-07 1.02226643544714e-05 TMSB4X/APOE/CD36/PLEK/NCKAP1L/ICAM1/TLR4/RB1/SYK/PTGER4/ABCA1/LCP1/HSPA1A/CLEC7A/ISG15/PREX1/FCHSD2/ATM/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/TGFB1/MSN/CAPG/CAPZA2/ATF7IP/EPS8/GSN 31 GO:0000302 response to reactive oxygen species 21/502 222/18722 6.15596116225949e-07 1.10377815258188e-05 APOE/CD36/TXNIP/ADAM9/KLF2/SLC8A1/FOS/SOD2/SIRPA/DUSP1/UCP2/GPX1/FOXO3/KLF4/NCF1/STAT1/SETX/HIF1A/SESN1/JUN/RHOB 21 GO:0002833 positive regulation of response to biotic stimulus 18/502 168/18722 6.39389317329942e-07 1.14201350655147e-05 TYROBP/LY96/TLR4/IFI16/CYBA/HLA-DRB1/HAVCR2/SPI1/SYK/HLA-E/GRN/LYN/CLEC7A/PARP9/PYCARD/LY86/PLSCR1/LAMP1 18 GO:0045860 positive regulation of protein kinase activity 29/502 386/18722 6.58093462770936e-07 1.17051411457585e-05 CSF1R/IGF1/CD4/GAS6/PDGFC/NCKAP1L/FCGR1A/TLR4/PTPRC/LCP2/CD86/CCDC88A/SYK/ADAM9/PRNP/JAK2/EGR1/IQGAP1/TGFBR2/TGFB1/NCF1/DAZAP2/TAOK3/ABI1/CAB39/CALM2/TAOK1/STK4/AKAP13 29 GO:0001916 positive regulation of T cell mediated cytotoxicity 8/502 29/18722 6.6040679616147e-07 1.17051411457585e-05 HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/HLA-E/STX7 8 GO:0032613 interleukin-10 production 11/502 62/18722 6.82094439575021e-07 1.19070523678266e-05 CD28/TYROBP/FCGR2B/TLR4/LGALS9/HLA-DRB1/SYK/CLEC7A/ISG15/PYCARD/STAT3 11 GO:0032653 regulation of interleukin-10 production 11/502 62/18722 6.82094439575021e-07 1.19070523678266e-05 CD28/TYROBP/FCGR2B/TLR4/LGALS9/HLA-DRB1/SYK/CLEC7A/ISG15/PYCARD/STAT3 11 GO:0032731 positive regulation of interleukin-1 beta production 11/502 62/18722 6.82094439575021e-07 1.19070523678266e-05 TYROBP/CCL3/CD36/TLR4/IFI16/LGALS9/CLEC7A/JAK2/PYCARD/EGR1/STAT3 11 GO:0045428 regulation of nitric oxide biosynthetic process 11/502 62/18722 6.82094439575021e-07 1.19070523678266e-05 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/SIRPA/TSPO/ACP5/KLF4 11 GO:0002347 response to tumor cell 9/502 39/18722 6.90459195513985e-07 1.20077602949161e-05 LAPTM5/HLA-A/HLA-DRB1/TXNIP/HAVCR2/SPI1/HNMT/KLF4/AHR 9 GO:0045621 positive regulation of lymphocyte differentiation 14/502 104/18722 7.24074589600255e-07 1.25452024400404e-05 GAS6/CR1/RUNX1/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/CD86/SYK/XBP1/TGFBR2/NFKBIZ 14 GO:0051235 maintenance of location 26/502 326/18722 8.19074122933013e-07 1.41381973607766e-05 CD4/CCL3/FTL/TMSB4X/APOE/CD36/MSR1/CYBA/SRGN/PTPRC/CCDC88A/MCOLN1/ITPR2/ABCA1/SLC8A1/LYN/VPS13C/FTH1/TSPO/NRIP1/PTPN6/SP100/GAA/CHCHD10/CALM2/GSN 26 GO:0031668 cellular response to extracellular stimulus 22/502 246/18722 8.69030900889903e-07 1.49447470167907e-05 FOLR2/CD68/GAS6/AIF1/ICAM1/IFI16/PTPRC/NR4A2/LYN/FOS/NAMPT/PDK4/CPEB4/XBP1/ATG7/GLUL/UCP2/FOXO3/LAMP2/SESN1/USF2/JUN 22 GO:0002275 myeloid cell activation involved in immune response 13/502 91/18722 9.02812586490393e-07 1.54111107937438e-05 FCER1G/TYROBP/CCL3/CD84/ITGB2/LGALS9/ITGAM/HAVCR2/SPI1/SYK/GRN/LYN/PYCARD 13 GO:0045582 positive regulation of T cell differentiation 13/502 91/18722 9.02812586490393e-07 1.54111107937438e-05 CR1/RUNX1/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/CD86/SYK/XBP1/TGFBR2/NFKBIZ 13 GO:0080164 regulation of nitric oxide metabolic process 11/502 64/18722 9.50802745921341e-07 1.6170637877324e-05 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/SIRPA/TSPO/ACP5/KLF4 11 GO:0002720 positive regulation of cytokine production involved in immune response 11/502 65/18722 1.11715864949009e-06 1.88612259581795e-05 CD74/CD36/LAPTM5/TLR4/B2M/HLA-A/RSAD2/HLA-E/CLEC7A/CD81/TNFRSF14 11 GO:0071677 positive regulation of mononuclear cell migration 11/502 65/18722 1.11715864949009e-06 1.88612259581795e-05 GAS6/CCL3/AIF1/LGMN/CCR1/LGALS9/CCL4/SPI1/TNFRSF14/PYCARD/ADAM10 11 GO:0030183 B cell differentiation 16/502 141/18722 1.24303200708922e-06 2.09100584174353e-05 CR1/FCGR2B/NCKAP1L/PTPRC/ZFP36L1/KLF6/RBPJ/SPI1/SYK/TNFSF13B/ATM/XBP1/ZFP36L2/LGALS1/PTPN6/PIK3R1 16 GO:2001233 regulation of apoptotic signaling pathway 27/502 356/18722 1.33720002789451e-06 2.23441212579284e-05 IGF1/CD74/ICAM1/CTSC/PTPRC/RB1/NR4A2/ARRB2/HSPA1A/NRP1/SOD2/SGMS1/PYCARD/XBP1/GPX1/CD44/MCL1/NUPR1/IVNS1ABP/GNAI2/HIF1A/TMBIM6/SP100/FEM1B/SKIL/STK4/HERPUD1 27 GO:0042060 wound healing 30/502 422/18722 1.33794240995378e-06 2.23441212579284e-05 F13A1/IGF1/GAS6/FCER1G/APOE/CD36/PLEK/TLR4/SYK/SERPING1/ALOX5/LYN/CLEC7A/ACTB/RAP2B/FERMT3/JAK2/XBP1/TGFBR2/PLSCR1/GPX1/CD44/WAS/TGFB1/TIMP1/JMJD1C/PTPN6/HIF1A/PRCP/MACF1 30 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 9/502 42/18722 1.3525352025111e-06 2.2506574988548e-05 SPI1/FOS/EGR1/FOXO3/KLF4/TGFB1/STAT3/HIF1A/JUN 9 GO:0009743 response to carbohydrate 22/502 253/18722 1.39222115112748e-06 2.30839248928878e-05 GAS6/ICAM1/CYBA/HLA-DRB1/TXNIP/ZFP36L1/SLC8A1/LYN/CLEC7A/NAMPT/SOD2/EGR1/XBP1/ATG7/GLUL/TGFBR2/UCP2/FOXO3/LGALS1/HIF1A/COLEC12/LRP1 22 GO:0002468 dendritic cell antigen processing and presentation 6/502 15/18722 1.46955706820635e-06 2.41927793506141e-05 CD68/FCGR2B/CD74/HLA-DRA/HLA-DRB1/FGL2 6 GO:0090594 inflammatory response to wounding 6/502 15/18722 1.46955706820635e-06 2.41927793506141e-05 TLR4/ALOX5/GRN/TGFB1/TIMP1/HIF1A 6 GO:0032479 regulation of type I interferon production 13/502 95/18722 1.49055684502615e-06 2.43650740815936e-05 CD14/TLR4/TLR7/HAVCR2/OAS2/SYK/ISG15/OAS1/SIRPA/PYCARD/REL/IFIH1/STAT1 13 GO:0032606 type I interferon production 13/502 95/18722 1.49055684502615e-06 2.43650740815936e-05 CD14/TLR4/TLR7/HAVCR2/OAS2/SYK/ISG15/OAS1/SIRPA/PYCARD/REL/IFIH1/STAT1 13 GO:0035456 response to interferon-beta 8/502 32/18722 1.50775223915267e-06 2.45593727405643e-05 BST2/IFI16/XAF1/IFITM2/IFITM3/OAS1/PLSCR1/STAT1 8 GO:0042130 negative regulation of T cell proliferation 11/502 67/18722 1.52826130968893e-06 2.48060941004245e-05 VSIG4/CR1/GPNMB/LGALS9/HLA-DRB1/CD86/HAVCR2/PRNP/TNFRSF14/PTPN6/PRKAR1A 11 GO:0007568 aging 26/502 339/18722 1.70624328649825e-06 2.75615219377246e-05 C1QA/CD68/ICAM1/CTSC/TNFRSF1B/B2M/TIMP2/SPI1/SERPING1/PRNP/FOS/NAMPT/SOD2/ATM/ATG7/TGFBR2/UCP2/FOXO3/TSPO/TIMP1/STAT3/LITAF/BAZ2B/JUN/LRP1/CITED2 26 GO:0008154 actin polymerization or depolymerization 20/502 217/18722 1.70993445657738e-06 2.75615219377246e-05 AIF1/TMSB4X/PLEK/NCKAP1L/ICAM1/WIPF1/PREX1/JAK2/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/ABI1/EPS8/GSN 20 GO:0061614 pri-miRNA transcription by RNA polymerase II 10/502 55/18722 1.73948687399283e-06 2.79405079135098e-05 SPI1/FOS/EGR1/FOXO3/KLF4/TGFB1/STAT3/HIF1A/DDX5/JUN 10 GO:0031334 positive regulation of protein-containing complex assembly 21/502 237/18722 1.78594156103592e-06 2.85874244337445e-05 CD36/PLEK/NCKAP1L/ICAM1/TLR4/SYK/ABCA1/LCP1/HSPA1A/CLEC7A/ISG15/FCHSD2/ATM/PYCARD/ACTR2/GMFG/CYFIP1/WAS/TGFB1/MSN/GSN 21 GO:0032633 interleukin-4 production 8/502 33/18722 1.94383263628655e-06 3.09009270634418e-05 CD28/FCER1G/LGALS9/HLA-DRB1/CD86/HAVCR2/SYK/HLA-E 8 GO:0032673 regulation of interleukin-4 production 8/502 33/18722 1.94383263628655e-06 3.09009270634418e-05 CD28/FCER1G/LGALS9/HLA-DRB1/CD86/HAVCR2/SYK/HLA-E 8 GO:0097191 extrinsic apoptotic signaling pathway 20/502 219/18722 1.97183950969261e-06 3.12387999035548e-05 IGF1/IFI27/ICAM1/PTPRC/TNFRSF1B/SPI1/HSPA1A/NRP1/JAK2/PYCARD/GPX1/FOXO3/TNFRSF1A/TGFB1/MCL1/SP100/FEM1B/PIK3R1/SKIL/STK4 20 GO:0031295 T cell costimulation 9/502 44/18722 2.05036021401128e-06 3.2371898805516e-05 CD28/CD86/MAP3K8/LYN/CD81/TNFSF13B/TNFRSF14/LGALS1/PTPN6 9 GO:0002711 positive regulation of T cell mediated immunity 10/502 56/18722 2.06741139235857e-06 3.2419813901867e-05 HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CD81/STX7 10 GO:0002886 regulation of myeloid leukocyte mediated immunity 10/502 56/18722 2.06741139235857e-06 3.2419813901867e-05 TYROBP/CD84/FCGR2B/ITGB2/LGALS9/ITGAM/SPI1/SYK/HLA-E/LYN 10 GO:0002921 negative regulation of humoral immune response 6/502 16/18722 2.2980952478567e-06 3.59155020830577e-05 VSIG4/A2M/CR1/FCGR2B/SERPING1/PTPN6 6 GO:0033209 tumor necrosis factor-mediated signaling pathway 13/502 99/18722 2.39685978877422e-06 3.73329070130287e-05 GAS6/TMSB4X/LAPTM5/TNFRSF1B/SYK/HSPA1A/TNFSF13B/JAK2/TNFRSF14/PYCARD/FOXO3/TNFRSF1A/STAT1 13 GO:1901342 regulation of vasculature development 26/502 348/18722 2.76765004616746e-06 4.29635876294317e-05 STAB1/CYBB/C3AR1/ENPP2/SPRED1/RUNX1/GPNMB/PLXND1/C5AR1/NINJ1/KLF2/ALOX5/GRN/MTDH/NRP1/XBP1/GLUL/TGFBR2/ENG/KLF4/STAT1/STAT3/HIF1A/SP100/RHOB/ADAM10 26 GO:0001959 regulation of cytokine-mediated signaling pathway 16/502 150/18722 2.83300857660608e-06 4.38310959042801e-05 GAS6/CD74/LAPTM5/PTPRC/SYK/SAMHD1/HSPA1A/PARP14/ISG15/PARP9/OAS1/PYCARD/PTPN6/HIF1A/STAT2/ADAR 16 GO:0043525 positive regulation of neuron apoptotic process 10/502 58/18722 2.88767223393396e-06 4.45279058472617e-05 TYROBP/CCL3/CTSZ/ITGAM/GRN/PRNP/FOXO3/MCL1/NUPR1/JUN 10 GO:0032753 positive regulation of interleukin-4 production 7/502 25/18722 3.02038656415494e-06 4.62659213436448e-05 CD28/FCER1G/LGALS9/CD86/HAVCR2/SYK/HLA-E 7 GO:0098581 detection of external biotic stimulus 7/502 25/18722 3.02038656415494e-06 4.62659213436448e-05 LY96/NAIP/HLA-B/TLR4/HLA-A/HLA-DRB1/CLEC7A 7 GO:0031294 lymphocyte costimulation 9/502 46/18722 3.03817972580801e-06 4.63848825464946e-05 CD28/CD86/MAP3K8/LYN/CD81/TNFSF13B/TNFRSF14/LGALS1/PTPN6 9 GO:0032729 positive regulation of interferon-gamma production 11/502 72/18722 3.18548431851919e-06 4.84738501890453e-05 CD14/TLR4/TLR7/LGALS9/HLA-A/HAVCR2/HLA-DPA1/HLA-DPB1/CLEC7A/ISG15/PYCARD 11 GO:0010038 response to metal ion 27/502 373/18722 3.23713321704543e-06 4.90982893837776e-05 C1QA/CD14/CYBB/MEF2C/LGMN/ICAM1/ALOX5AP/B2M/TXNIP/MCOLN1/ADAM9/PRNP/MEF2A/FOS/JUNB/SOD2/SLC11A2/IQGAP1/DUSP1/PLSCR1/FOSB/TSPO/NCF1/ADCY7/HIF1A/JUN/CALM2 27 GO:0032677 regulation of interleukin-8 production 13/502 102/18722 3.36848033646754e-06 5.07576222687259e-05 CD14/TMSB4X/CD74/TLR4/TLR7/LGALS9/PTPRC/SYK/HSPA1A/CLEC7A/PYCARD/KLF4/STAT3 13 GO:1902106 negative regulation of leukocyte differentiation 13/502 102/18722 3.36848033646754e-06 5.07576222687259e-05 C1QC/TMEM176B/TMEM176A/CR1/RUNX1/CCL3/FCGR2B/MAFB/CD74/TLR4/LYN/FGL2/PIK3R1 13 GO:0043299 leukocyte degranulation 11/502 73/18722 3.66121505746612e-06 5.48627190891501e-05 CCL3/CD84/FCGR2B/NCKAP1L/ITGB2/LGALS9/ITGAM/SPI1/SYK/LYN/LAMP1 11 GO:0072583 clathrin-dependent endocytosis 9/502 47/18722 3.66935725459562e-06 5.48627190891501e-05 SIGLEC1/DAB2/BMP2K/ITSN1/CLTC/FCHSD2/ITSN2/AP2A2/FCHO2 9 GO:0033002 muscle cell proliferation 21/502 248/18722 3.6764900383996e-06 5.48627190891501e-05 MEF2C/IGF1/RUNX1/AIF1/APOE/TLR4/CYBA/RBPJ/NAMPT/JAK2/SOD2/TGFBR2/KLF4/TGFB1/STAT1/STAT3/GNAI2/JUN/CITED2/PRKAR1A/GNA13 21 GO:0032637 interleukin-8 production 13/502 103/18722 3.76228673783144e-06 5.59625030521165e-05 CD14/TMSB4X/CD74/TLR4/TLR7/LGALS9/PTPRC/SYK/HSPA1A/CLEC7A/PYCARD/KLF4/STAT3 13 GO:1902905 positive regulation of supramolecular fiber organization 19/502 209/18722 3.79429755821211e-06 5.6257758026568e-05 APOE/PLEK/NCKAP1L/ICAM1/MTSS1/RB1/CCDC88A/COLGALT1/HSPA1A/NRP1/FCHSD2/PYCARD/GPX1/ACTR2/GPR65/GMFG/CYFIP1/WAS/GSN 19 GO:0006979 response to oxidative stress 30/502 446/18722 4.10243196734832e-06 6.06321095238126e-05 AIF1/APOE/CD36/TLR4/TXNIP/NR4A2/ADAM9/KLF2/ALOX5/HSPA1A/PRNP/SLC8A1/FOS/JAK2/SOD2/SIRPA/ATG7/DUSP1/UCP2/GPX1/FOXO3/KLF4/NCF1/MCL1/STAT1/SETX/HIF1A/SESN1/JUN/RHOB 30 GO:0002437 inflammatory response to antigenic stimulus 11/502 74/18722 4.19794520199859e-06 6.18461608421831e-05 CD68/CD28/FCGR2B/ICAM1/HLA-DRB1/RBPJ/SYK/HLA-E/LYN/CD81/GPX1 11 GO:0043030 regulation of macrophage activation 10/502 61/18722 4.64404115468708e-06 6.8201061528833e-05 VSIG4/CCL3/CD84/FCGR2B/CD74/TLR4/CTSC/PTPRC/HAVCR2/GRN 10 GO:0007265 Ras protein signal transduction 25/502 337/18722 4.87070193830597e-06 7.09003819854924e-05 LPAR6/IGF1/CYTH4/AIF1/APOE/DENND3/ARHGAP4/RB1/TIMP2/ABCA1/DOK2/NRP1/RAP2B/SDCBP/CYTH1/GPR65/CYFIP1/WAS/ARHGDIB/JUN/MYO9B/RHOB/EPS8/GNA13/AKAP13 25 GO:0062197 cellular response to chemical stress 25/502 337/18722 4.87070193830597e-06 7.09003819854924e-05 AIF1/CD36/TLR4/ZFP36L1/NR4A2/KLF2/ALOX5/HSPA1A/FOS/JAK2/SOD2/ATM/SIRPA/ATG7/GPX1/FOXO3/TSPO/KLF4/NCF1/MCL1/SETX/HIF1A/JUN/RHOB/CAB39 25 GO:2000146 negative regulation of cell motility 26/502 359/18722 4.87382651780946e-06 7.09003819854924e-05 MEF2C/CCL2/SPRED1/TMIGD3/AIF1/APOE/CD74/BST2/ARHGAP4/PTGER4/RAP2B/DUSP1/ENG/FOXO3/WAS/KLF4/TGFB1/ARHGDIB/TIMP1/STAT3/DUSP3/SP100/LRP1/RHOB/CITED2/GNA13 26 GO:0002283 neutrophil activation involved in immune response 6/502 18/18722 5.08923582274408e-06 7.35712653625441e-05 FCER1G/TYROBP/ITGB2/ITGAM/SPI1/SYK 6 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 6/502 18/18722 5.08923582274408e-06 7.35712653625441e-05 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E 6 GO:1901654 response to ketone 18/502 194/18722 5.11374514831513e-06 7.36952805486161e-05 SPP1/CYBB/GAS6/ICAM1/CYBA/TXNIP/PTGER4/KLF2/FOS/DUSP1/FOXO3/FOSB/TSPO/KLF4/TGFB1/MSN/NCOA4/AHR 18 GO:1903707 negative regulation of hemopoiesis 13/502 106/18722 5.19930743506063e-06 7.4695640355871e-05 C1QC/TMEM176B/TMEM176A/CR1/RUNX1/CCL3/FCGR2B/MAFB/CD74/TLR4/LYN/FGL2/PIK3R1 13 GO:0032703 negative regulation of interleukin-2 production 7/502 27/18722 5.3260899766635e-06 7.58422818176484e-05 VSIG4/CR1/LAPTM5/PTPRC/HAVCR2/ZFP36/PRNP 7 GO:0006959 humoral immune response 24/502 317/18722 5.32830557516985e-06 7.58422818176484e-05 C1QA/C1QB/C1QC/VSIG4/A2M/MEF2C/C2/CCL2/CD28/CR1/FCGR2B/CFD/RNASE6/PTPRC/HLA-A/HLA-DRB1/RBPJ/POU2F2/HLA-DQB1/SERPING1/HLA-E/ALOX5/CD81/PTPN6 24 GO:0010506 regulation of autophagy 24/502 317/18722 5.32830557516985e-06 7.58422818176484e-05 IFI16/PSAP/IL10RA/MTDH/NAMPT/VPS13C/ATM/PYCARD/TRIM22/ATG7/ATP6V0A1/SNX6/FOXO3/TSPO/MCL1/SPTLC2/ATP6V0B/NUPR1/STAT3/HIF1A/SESN1/DRAM2/BNIP3L/TRIM38 24 GO:0032615 interleukin-12 production 10/502 62/18722 5.40595398451629e-06 7.62437290621109e-05 CMKLR1/CD36/LAPTM5/HLA-B/TLR4/LGALS9/SYK/ARRB2/CLEC7A/ACP5 10 GO:0032655 regulation of interleukin-12 production 10/502 62/18722 5.40595398451629e-06 7.62437290621109e-05 CMKLR1/CD36/LAPTM5/HLA-B/TLR4/LGALS9/SYK/ARRB2/CLEC7A/ACP5 10 GO:0032757 positive regulation of interleukin-8 production 10/502 62/18722 5.40595398451629e-06 7.62437290621109e-05 CD14/CD74/TLR4/TLR7/LGALS9/SYK/HSPA1A/CLEC7A/PYCARD/STAT3 10 GO:0006809 nitric oxide biosynthetic process 11/502 76/18722 5.48105683392371e-06 7.67561927664874e-05 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/SIRPA/TSPO/ACP5/KLF4 11 GO:0032720 negative regulation of tumor necrosis factor production 11/502 76/18722 5.48105683392371e-06 7.67561927664874e-05 IGF1/GAS6/GPNMB/TLR4/LGALS9/HAVCR2/ARRB2/SIRPA/TSPO/ACP5/PTPN6 11 GO:0045657 positive regulation of monocyte differentiation 5/502 11/18722 5.49206653819873e-06 7.67561927664874e-05 CD4/CD74/HLA-DRB1/ZFP36L1/JUN 5 GO:0007204 positive regulation of cytosolic calcium ion concentration 24/502 319/18722 5.93040184162509e-06 8.26326473474628e-05 LPAR6/C3AR1/CMKLR1/CCL3/CD36/CCR1/CYBA/PTPRC/MCOLN1/ITPR2/FPR3/C5AR1/PTGER4/PRNP/FPR1/SLC8A1/LYN/JAK2/GPR65/PTPN6/TMBIM6/LRP1/CALM2/GNA13 24 GO:0071559 response to transforming growth factor beta 21/502 256/18722 6.04141673587724e-06 8.39267081686731e-05 MEF2C/ZEB2/SPRED1/DAB2/ZFP36L1/SPI1/ARRB2/ADAM9/HSPA1A/FOS/TGFBR2/SDCBP/ZFP36L2/ENG/SNX6/TGFB1/STAT3/ZFHX3/JUN/CITED2/SKIL 21 GO:0009595 detection of biotic stimulus 8/502 38/18722 6.08553329417812e-06 8.40348567727402e-05 LY96/NAIP/HLA-B/TLR4/HLA-A/HLA-DRB1/CLEC7A/TSPO 8 GO:0097242 amyloid-beta clearance 8/502 38/18722 6.08553329417812e-06 8.40348567727402e-05 APOE/CD36/MSR1/ITGB2/ITGAM/C5AR1/CLTC/LRP1 8 GO:0110053 regulation of actin filament organization 22/502 277/18722 6.13229028653181e-06 8.42771986496064e-05 TMSB4X/PLEK/NCKAP1L/ICAM1/MTSS1/CCDC88A/PTGER4/NRP1/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GPR65/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/PIK3R1/GSN 22 GO:0002377 immunoglobulin production 19/502 216/18722 6.13951922717625e-06 8.42771986496064e-05 CD28/CR1/FCGR2B/HLA-DMB/PTPRC/HLA-DRA/B2M/HLA-DRB1/CD86/HLA-DQA1/HLA-DQB1/HLA-DMA/SAMHD1/HLA-DPA1/HLA-E/HLA-DPB1/XBP1/TGFB1/TMBIM6 19 GO:0046638 positive regulation of alpha-beta T cell differentiation 9/502 50/18722 6.2818936213839e-06 8.59764493861596e-05 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/SYK/TGFBR2/NFKBIZ 9 GO:0045765 regulation of angiogenesis 25/502 342/18722 6.30259408499745e-06 8.6005310434213e-05 STAB1/CYBB/C3AR1/ENPP2/SPRED1/RUNX1/GPNMB/PLXND1/C5AR1/NINJ1/KLF2/ALOX5/GRN/MTDH/NRP1/XBP1/GLUL/TGFBR2/ENG/KLF4/STAT1/STAT3/HIF1A/SP100/RHOB 25 GO:0030336 negative regulation of cell migration 25/502 344/18722 6.97571773096049e-06 9.49107947747742e-05 MEF2C/CCL2/SPRED1/TMIGD3/AIF1/APOE/CD74/BST2/ARHGAP4/PTGER4/RAP2B/DUSP1/ENG/FOXO3/KLF4/TGFB1/ARHGDIB/TIMP1/STAT3/DUSP3/SP100/LRP1/RHOB/CITED2/GNA13 25 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 11/502 78/18722 7.09388327282892e-06 9.62354956601366e-05 IGF1/GAS6/GPNMB/TLR4/LGALS9/HAVCR2/ARRB2/SIRPA/TSPO/ACP5/PTPN6 11 GO:0051271 negative regulation of cellular component movement 26/502 367/18722 7.23462457359918e-06 9.78578166007889e-05 MEF2C/CCL2/SPRED1/TMIGD3/AIF1/APOE/CD74/BST2/ARHGAP4/PTGER4/RAP2B/DUSP1/ENG/FOXO3/WAS/KLF4/TGFB1/ARHGDIB/TIMP1/STAT3/DUSP3/SP100/LRP1/RHOB/CITED2/GNA13 26 GO:0002716 negative regulation of natural killer cell mediated immunity 6/502 19/18722 7.2700657661161e-06 9.80505079710002e-05 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E 6 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 8/502 39/18722 7.47781048093015e-06 0.000100559160711578 NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/CD81/TGFBR2/NFKBIZ 8 GO:0040013 negative regulation of locomotion 27/502 391/18722 7.73096008822476e-06 0.000103662090922109 MEF2C/CCL2/SPRED1/TMIGD3/AIF1/APOE/CD74/BST2/ARHGAP4/PTGER4/NRP1/RAP2B/DUSP1/ENG/FOXO3/WAS/KLF4/TGFB1/ARHGDIB/TIMP1/STAT3/DUSP3/SP100/LRP1/RHOB/CITED2/GNA13 27 GO:0052547 regulation of peptidase activity 30/502 461/18722 7.87736371514801e-06 0.000105319897532586 A2M/GAS6/CR1/LGMN/NAIP/LAPTM5/BST2/IFI16/LGALS9/TIMP2/CST3/SYK/SERPING1/ARRB2/GRN/PRNP/CTSD/LYN/CLEC7A/JAK2/PYCARD/GPX1/CD44/KLF4/NR4A1/TIMP1/STAT3/LRP1/GSN/HERPUD1 30 GO:0048524 positive regulation of viral process 10/502 65/18722 8.3762638739895e-06 0.000111667425593877 CD4/CD209/CD28/CD74/LGALS9/HLA-DRB1/IFIT1/LGALS1/TRIM38/ADAR 10 GO:1903902 positive regulation of viral life cycle 7/502 29/18722 8.9357260680309e-06 0.00011878353100779 CD4/CD209/CD74/LGALS9/HLA-DRB1/LGALS1/TRIM38 7 GO:0045429 positive regulation of nitric oxide biosynthetic process 8/502 40/18722 9.12978195941906e-06 0.000120954800258 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/KLF4 8 GO:0045580 regulation of T cell differentiation 15/502 146/18722 9.15135756383487e-06 0.000120954800258 CD28/CR1/RUNX1/CD74/NCKAP1L/LGALS9/PTPRC/HLA-DRA/HLA-DRB1/CD86/SYK/FGL2/XBP1/TGFBR2/NFKBIZ 15 GO:0034154 toll-like receptor 7 signaling pathway 5/502 12/18722 9.20739907713535e-06 0.000121004057189853 TLR7/UNC93B1/RSAD2/PIK3AP1/HAVCR2 5 GO:0043301 negative regulation of leukocyte degranulation 5/502 12/18722 9.20739907713535e-06 0.000121004057189853 CD84/FCGR2B/NCKAP1L/LGALS9/SPI1 5 GO:0002577 regulation of antigen processing and presentation 6/502 20/18722 1.01512729246336e-05 0.000132654769913432 CD68/FCGR2B/CD74/FGL2/PYCARD/WAS 6 GO:0098543 detection of other organism 6/502 20/18722 1.01512729246336e-05 0.000132654769913432 NAIP/HLA-B/TLR4/HLA-A/HLA-DRB1/CLEC7A 6 GO:0046209 nitric oxide metabolic process 11/502 81/18722 1.02854504477615e-05 0.000134029559919281 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/SIRPA/TSPO/ACP5/KLF4 11 GO:0043112 receptor metabolic process 16/502 166/18722 1.05132402258518e-05 0.000136613059788738 FCER1G/LGMN/APOE/CD36/LAPTM5/ITGB2/SYK/ARRB2/CD81/CLTC/CD63/EPS15/SDCBP/DTX3L/TGFB1/LRP1 16 GO:0002708 positive regulation of lymphocyte mediated immunity 13/502 113/18722 1.05794354929933e-05 0.000137088147312569 CD28/HLA-B/PTPRC/HLA-DRA/B2M/HLA-A/HLA-DRB1/RSAD2/HLA-E/CD81/STX7/LAMP1/TGFB1 13 GO:0097530 granulocyte migration 15/502 148/18722 1.07987871111076e-05 0.000139539634569787 CSF1R/CCL2/C3AR1/CMKLR1/FCER1G/CCL3/CD74/NCKAP1L/ITGB2/CCL4/SYK/C5AR1/PTGER4/PECAM1/PREX1 15 GO:0035914 skeletal muscle cell differentiation 10/502 67/18722 1.10611714254973e-05 0.000141973648303823 MEF2C/RB1/FOS/EGR1/BTG2/NR4A1/NUPR1/DDX17/DDX5/CITED2 10 GO:0032733 positive regulation of interleukin-10 production 8/502 41/18722 1.10792233112149e-05 0.000141973648303823 CD28/TLR4/LGALS9/SYK/CLEC7A/ISG15/PYCARD/STAT3 8 GO:1904407 positive regulation of nitric oxide metabolic process 8/502 41/18722 1.10792233112149e-05 0.000141973648303823 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/KLF4 8 GO:0097193 intrinsic apoptotic signaling pathway 22/502 288/18722 1.13749960118592e-05 0.000145121422241831 CD74/IFI16/TNFRSF1B/HSPA1A/JAK2/SOD2/ATM/SGMS1/PYCARD/XBP1/GPX1/CD44/TNFRSF1A/MCL1/NUPR1/IVNS1ABP/HIF1A/DDX5/TMBIM6/PIK3R1/SKIL/HERPUD1 22 GO:0045577 regulation of B cell differentiation 7/502 30/18722 1.13876083600918e-05 0.000145121422241831 CR1/NCKAP1L/ZFP36L1/SYK/XBP1/ZFP36L2/PTPN6 7 GO:2001057 reactive nitrogen species metabolic process 11/502 82/18722 1.15961421578799e-05 0.000147372949511958 AIF1/CD36/ICAM1/TLR4/KLF2/CLEC7A/JAK2/SIRPA/TSPO/ACP5/KLF4 11 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 9/502 54/18722 1.21242510738577e-05 0.000153553254024776 SPI1/FOS/EGR1/FOXO3/KLF4/TGFB1/STAT3/HIF1A/JUN 9 GO:0031098 stress-activated protein kinase signaling cascade 20/502 247/18722 1.21488307334777e-05 0.000153553254024776 FCGR2B/TLR4/TLR7/LGALS9/ZFP36L1/SPI1/ZFP36/PTGER4/LYN/CLEC7A/SIRPA/PYCARD/DUSP1/SDCBP/GADD45B/RNF13/NCF1/DUSP3/TAOK3/TAOK1 20 GO:0030278 regulation of ossification 13/502 115/18722 1.28239104253179e-05 0.0001616441679224 MEF2C/CCL3/CCR1/BMP2K/SRGN/RBPJ/PTGER4/ALOX5/SLC8A1/ISG15/TGFB1/DHRS3/HIF1A 13 GO:0032689 negative regulation of interferon-gamma production 8/502 42/18722 1.33678558073805e-05 0.000168042665665604 GAS6/CR1/LAPTM5/TLR4/LGALS9/HLA-DRB1/HAVCR2/PRNP 8 GO:0002444 myeloid leukocyte mediated immunity 12/502 99/18722 1.34886551008881e-05 0.000168204627071477 TYROBP/CCL3/CD84/FCGR2B/ITGB2/LGALS9/ITGAM/SPI1/SYK/HLA-E/LYN/KMT2E 12 GO:0042100 B cell proliferation 12/502 99/18722 1.34886551008881e-05 0.000168204627071477 MEF2C/TYROBP/FCGR2B/CD74/NCKAP1L/TLR4/PTPRC/LYN/CD81/TNFSF13B/ATM/AHR 12 GO:0031667 response to nutrient levels 30/502 474/18722 1.348982201546e-05 0.000168204627071477 SPP1/FOLR2/CYBB/C2/CD68/GAS6/APOE/ICAM1/IFI16/CYBA/ZFP36/ABCA1/SLC8A1/NAMPT/PDK4/SOD2/CPEB4/XBP1/ATG7/GLUL/TGFBR2/UCP2/FOXO3/TSPO/LAMP2/STAT1/GNAI2/SESN1/USF2/JUN 30 GO:0150146 cell junction disassembly 6/502 21/18722 1.38909982679457e-05 0.00017274128491268 C1QA/C1QB/C1QC/ITGAM/DUSP3/PIK3R1 6 GO:0071560 cellular response to transforming growth factor beta stimulus 20/502 250/18722 1.45023305901304e-05 0.000179860003511912 MEF2C/ZEB2/SPRED1/DAB2/ZFP36L1/SPI1/ARRB2/ADAM9/HSPA1A/FOS/TGFBR2/SDCBP/ZFP36L2/ENG/SNX6/TGFB1/STAT3/JUN/CITED2/SKIL 20 GO:2001198 regulation of dendritic cell differentiation 5/502 13/18722 1.46323604505976e-05 0.000180696183348421 TMEM176B/TMEM176A/FCGR2B/HLA-B/LGALS9 5 GO:0032535 regulation of cellular component size 26/502 382/18722 1.46478747850536e-05 0.000180696183348421 SPP1/TMSB4X/APOE/PLEK/NCKAP1L/ICAM1/ARHGAP4/NRP1/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/TMEM123/MSN/RTN4/CAPG/CAPZA2/LRP1/MACF1/GOLGA4/EPS8/GSN 26 GO:0045807 positive regulation of endocytosis 12/502 100/18722 1.4961375962149e-05 0.000184072673406652 CD14/APOE/DAB2/CD36/NCKAP1L/B2M/ITSN1/SYK/ARRB2/CD63/PPT1/LRP1 12 GO:0030041 actin filament polymerization 17/502 190/18722 1.50456169677891e-05 0.00018461810104242 AIF1/TMSB4X/NCKAP1L/ICAM1/PREX1/JAK2/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 17 GO:0002861 regulation of inflammatory response to antigenic stimulus 8/502 43/18722 1.60415862511879e-05 0.000196318460312156 CD28/FCGR2B/HLA-DRB1/SYK/HLA-E/LYN/CD81/GPX1 8 GO:0048545 response to steroid hormone 24/502 339/18722 1.6395144437278e-05 0.000199985245949378 SPP1/CYBB/AIF1/DAB2/ICAM1/CYBA/TXNIP/ZFP36L1/ZFP36/ADAM9/FOS/HNMT/JAK2/DUSP1/TGFBR2/ZFP36L2/ENG/FOXO3/FOSB/TSPO/TGFB1/NCOA4/DDX17/DDX5 24 GO:0032608 interferon-beta production 9/502 56/18722 1.64708989854546e-05 0.000199985245949378 TLR4/TLR7/OAS2/ISG15/OAS1/SIRPA/PYCARD/REL/IFIH1 9 GO:0032648 regulation of interferon-beta production 9/502 56/18722 1.64708989854546e-05 0.000199985245949378 TLR4/TLR7/OAS2/ISG15/OAS1/SIRPA/PYCARD/REL/IFIH1 9 GO:0052548 regulation of endopeptidase activity 28/502 432/18722 1.69967182683871e-05 0.00020582936834963 A2M/GAS6/CR1/LGMN/NAIP/LAPTM5/BST2/IFI16/LGALS9/TIMP2/CST3/SYK/SERPING1/ARRB2/PRNP/CTSD/LYN/CLEC7A/JAK2/PYCARD/GPX1/CD44/KLF4/NR4A1/TIMP1/STAT3/GSN/HERPUD1 28 GO:0035710 CD4-positive, alpha-beta T cell activation 12/502 102/18722 1.83331235882953e-05 0.000221433497962021 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/RSAD2/PTGER4/CD81/TGFBR2/STAT3/NFKBIZ 12 GO:0071404 cellular response to low-density lipoprotein particle stimulus 6/502 22/18722 1.86692043043039e-05 0.00022490557060341 FCER1G/CD36/ITGB2/SYK/ABCA1/CD81 6 GO:0060760 positive regulation of response to cytokine stimulus 9/502 57/18722 1.91002241625413e-05 0.0002295003557816 GAS6/CD74/LAPTM5/TLR4/HSPA1A/PARP14/PARP9/IFIH1/HIF1A 9 GO:0030004 cellular monovalent inorganic cation homeostasis 12/502 103/18722 2.02545526235213e-05 0.000242739793876708 SLC9A9/ATP1B1/GRN/SLC8A1/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1/SLC1A3/SLC4A7/ATP6AP1 12 GO:0048771 tissue remodeling 16/502 175/18722 2.04140103148293e-05 0.000244018634926099 SPP1/CSF1R/MEF2C/RUNX1/GPNMB/TPP1/RBPJ/CST3/SYK/PDK4/LIPA/ACP5/TGFB1/TIMP1/HIF1A/ATP6AP1 16 GO:0002534 cytokine production involved in inflammatory response 10/502 72/18722 2.12187735082768e-05 0.000251687298075098 TLR4/PLD3/ALOX5/CLEC7A/SIRPA/PYCARD/GPSM3/STAT3/ADCY7/HIF1A 10 GO:0043903 regulation of biological process involved in symbiotic interaction 10/502 72/18722 2.12187735082768e-05 0.000251687298075098 CD4/CD74/LGALS9/HLA-DRB1/IFITM2/IFITM3/TRIM22/LGALS1/TRIM38/GSN 10 GO:1900015 regulation of cytokine production involved in inflammatory response 10/502 72/18722 2.12187735082768e-05 0.000251687298075098 TLR4/PLD3/ALOX5/CLEC7A/SIRPA/PYCARD/GPSM3/STAT3/ADCY7/HIF1A 10 GO:0009410 response to xenobiotic stimulus 29/502 462/18722 2.18628167272832e-05 0.000258663401995939 CYBB/MEF2C/GAS6/NCKAP1L/ICAM1/CYBA/B2M/TXNIP/RB1/TIMP2/ABCA1/PRNP/SLC8A1/LYN/FOS/SOD2/TGFBR2/GPX1/ENG/RNF149/FOXO3/FOSB/TSPO/LGALS1/STAT1/STAT3/AHR/SLC1A3/JUN 29 GO:0032481 positive regulation of type I interferon production 9/502 58/18722 2.20780398228978e-05 0.000260543398522258 CD14/TLR4/TLR7/OAS2/SYK/ISG15/OAS1/IFIH1/STAT1 9 GO:1904019 epithelial cell apoptotic process 13/502 121/18722 2.22612838728675e-05 0.000261693763925646 CCL2/GAS6/ICAM1/ZFP36L1/RB1/ZFP36/ARRB2/JAK2/TGFBR2/FOXO3/NUPR1/GSN/STK4 13 GO:0045648 positive regulation of erythrocyte differentiation 7/502 33/18722 2.22886603948778e-05 0.000261693763925646 NCKAP1L/HSPA1A/ISG15/FOXO3/STAT1/STAT3/HIF1A 7 GO:0009612 response to mechanical stimulus 18/502 216/18722 2.23919612040666e-05 0.000262241044379778 TLR4/TLR7/CYBA/TXNIP/PTGER4/SLC8A1/FOS/BTG2/TGFBR2/ENG/FOSB/TNFRSF1A/STAT1/SLC1A3/JUN/MAP3K1/CITED2/GSN 18 GO:0071453 cellular response to oxygen levels 16/502 177/18722 2.3505576882188e-05 0.000274587875396469 CYBB/ICAM1/ZFP36L1/RBPJ/MALAT1/SLC8A1/NAMPT/CPEB4/EGR1/ATG7/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2/ATP6AP1 16 GO:0007596 blood coagulation 18/502 217/18722 2.38235835890748e-05 0.000277601757388061 F13A1/GAS6/FCER1G/APOE/CD36/PLEK/TLR4/SYK/SERPING1/LYN/ACTB/RAP2B/FERMT3/JAK2/PLSCR1/WAS/JMJD1C/PTPN6 18 GO:0070482 response to oxygen levels 24/502 347/18722 2.40005582974558e-05 0.000278321580444749 CYBB/ATP1B1/ICAM1/CYBA/ZFP36L1/RBPJ/ITPR2/NR4A2/MALAT1/SLC8A1/NAMPT/SOD2/CPEB4/SLC11A2/EGR1/ATG7/TGFBR2/UCP2/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2/ATP6AP1 24 GO:0050848 regulation of calcium-mediated signaling 10/502 73/18722 2.40056875480879e-05 0.000278321580444749 IGF1/CD4/CMKLR1/CCL3/PLEK/CCL4/SYK/PRNP/CLEC7A/CALM2 10 GO:0045936 negative regulation of phosphate metabolic process 28/502 441/18722 2.46636740454899e-05 0.000284813382210394 SPRED1/APOE/PLEK/NCKAP1L/SAMSN1/PTPRC/RB1/ARRB2/PRNP/PARP14/SLC8A1/LYN/SIRPA/PYCARD/DUSP1/ENG/SNX6/GADD45B/TGFB1/NUPR1/PTPN6/STAT3/GNAI2/DUSP3/LRP1/CALM2/ADAR/PRKAR1A 28 GO:1903306 negative regulation of regulated secretory pathway 6/502 23/18722 2.46887518950212e-05 0.000284813382210394 CD84/FCGR2B/NCKAP1L/LGALS9/SPI1/GNAI2 6 GO:0002820 negative regulation of adaptive immune response 9/502 59/18722 2.54410633174665e-05 0.000292762086832338 CR1/FCGR2B/NCKAP1L/SAMSN1/PTPRC/HAVCR2/TNFRSF14/PTPN6/AHR 9 GO:0010563 negative regulation of phosphorus metabolic process 28/502 442/18722 2.56854530467449e-05 0.00029421528925781 SPRED1/APOE/PLEK/NCKAP1L/SAMSN1/PTPRC/RB1/ARRB2/PRNP/PARP14/SLC8A1/LYN/SIRPA/PYCARD/DUSP1/ENG/SNX6/GADD45B/TGFB1/NUPR1/PTPN6/STAT3/GNAI2/DUSP3/LRP1/CALM2/ADAR/PRKAR1A 28 GO:0007179 transforming growth factor beta receptor signaling pathway 17/502 198/18722 2.56945475270547e-05 0.00029421528925781 ZEB2/SPRED1/DAB2/SPI1/ARRB2/ADAM9/HSPA1A/FOS/TGFBR2/SDCBP/ENG/SNX6/TGFB1/STAT3/JUN/CITED2/SKIL 17 GO:0050852 T cell receptor signaling pathway 13/502 123/18722 2.65396387836897e-05 0.000303141651884811 CD28/LAPTM5/PTPRC/HLA-A/HLA-DRB1/LCP2/HLA-DQB1/HLA-DPB1/PRNP/CD81/PTPN6/DUSP3/NFKBIZ 13 GO:0050851 antigen receptor-mediated signaling pathway 19/502 240/18722 2.73361052104319e-05 0.000311470006658763 MEF2C/CD28/FCGR2B/LAPTM5/NCKAP1L/PTPRC/HLA-A/HLA-DRB1/LCP2/HLA-DQB1/SYK/HLA-DPB1/PRNP/LYN/CD81/CMTM3/PTPN6/DUSP3/NFKBIZ 19 GO:0050869 negative regulation of B cell activation 7/502 34/18722 2.74235418238003e-05 0.000311698536798281 CR1/TYROBP/FCGR2B/LAPTM5/SAMSN1/LYN/ATM 7 GO:0042742 defense response to bacterium 24/502 350/18722 2.75896548609198e-05 0.000312817998496606 STAB1/CD4/MPEG1/FCER1G/CD36/NAIP/RNASE6/TLR4/CYBA/HLA-A/RBPJ/HAVCR2/OAS2/SYK/C5AR1/HLA-E/GRN/ISG15/TNFRSF14/OAS1/PYCARD/ACP5/TNFRSF1A/COLEC12 24 GO:0048660 regulation of smooth muscle cell proliferation 16/502 180/18722 2.89221704668837e-05 0.000327124597994631 MEF2C/IGF1/AIF1/APOE/TLR4/CYBA/NAMPT/JAK2/SOD2/TGFBR2/KLF4/TGFB1/STAT1/GNAI2/JUN/GNA13 16 GO:0071621 granulocyte chemotaxis 13/502 125/18722 3.15203060588293e-05 0.000355546082940635 CSF1R/CCL2/C3AR1/CMKLR1/FCER1G/CCL3/CD74/NCKAP1L/ITGB2/CCL4/SYK/C5AR1/PREX1 13 GO:0051480 regulation of cytosolic calcium ion concentration 24/502 353/18722 3.16558922140008e-05 0.000355546082940635 LPAR6/C3AR1/CMKLR1/CCL3/CD36/CCR1/CYBA/PTPRC/MCOLN1/ITPR2/FPR3/C5AR1/PTGER4/PRNP/FPR1/SLC8A1/LYN/JAK2/GPR65/PTPN6/TMBIM6/LRP1/CALM2/GNA13 24 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 8/502 47/18722 3.16655828299917e-05 0.000355546082940635 RBPJ/KLF2/HSPA1A/EGR1/HIF1A/TMBIM6/JUN/CITED2 8 GO:0007035 vacuolar acidification 6/502 24/18722 3.21763714654619e-05 0.000359817419537548 GRN/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1 6 GO:0007599 hemostasis 18/502 222/18722 3.22793404902902e-05 0.000359817419537548 F13A1/GAS6/FCER1G/APOE/CD36/PLEK/TLR4/SYK/SERPING1/LYN/ACTB/RAP2B/FERMT3/JAK2/PLSCR1/WAS/JMJD1C/PTPN6 18 GO:0050817 coagulation 18/502 222/18722 3.22793404902902e-05 0.000359817419537548 F13A1/GAS6/FCER1G/APOE/CD36/PLEK/TLR4/SYK/SERPING1/LYN/ACTB/RAP2B/FERMT3/JAK2/PLSCR1/WAS/JMJD1C/PTPN6 18 GO:0034405 response to fluid shear stress 7/502 35/18722 3.34935992449822e-05 0.00037245526468098 MEF2C/MTSS1/ADAM9/KLF2/ABCA1/KLF4/CITED2 7 GO:0034599 cellular response to oxidative stress 21/502 288/18722 3.57535384086081e-05 0.000396632778604846 AIF1/CD36/TLR4/NR4A2/KLF2/ALOX5/HSPA1A/FOS/JAK2/SOD2/SIRPA/ATG7/GPX1/FOXO3/KLF4/NCF1/MCL1/SETX/HIF1A/JUN/RHOB 21 GO:0050878 regulation of body fluid levels 25/502 379/18722 3.58949976748912e-05 0.000397249424028819 F13A1/GAS6/FCER1G/APOE/CD36/PLEK/TLR4/CYBA/OAS2/SYK/SERPING1/LYN/ACTB/RAP2B/FERMT3/JAK2/XBP1/PLSCR1/WAS/PRKACB/JMJD1C/PTPN6/GNAI2/HIF1A/USF2 25 GO:2001234 negative regulation of apoptotic signaling pathway 18/502 224/18722 3.63481901681495e-05 0.000401304839422099 IGF1/CD74/ICAM1/RB1/NR4A2/ARRB2/HSPA1A/NRP1/SOD2/XBP1/GPX1/CD44/MCL1/IVNS1ABP/GNAI2/HIF1A/TMBIM6/HERPUD1 18 GO:2001242 regulation of intrinsic apoptotic signaling pathway 15/502 164/18722 3.6661909761453e-05 0.000403804748944004 CD74/HSPA1A/SOD2/SGMS1/PYCARD/XBP1/GPX1/CD44/MCL1/NUPR1/IVNS1ABP/HIF1A/TMBIM6/SKIL/HERPUD1 15 GO:0031331 positive regulation of cellular catabolic process 27/502 427/18722 3.68948614657226e-05 0.000405405294870386 IGF1/APOE/DAB2/LAPTM5/CTSC/TNFRSF1B/ZFP36L1/ZFP36/ADAM9/HSPA1A/MTDH/CD81/TRIM22/BTG2/ATG7/ZFP36L2/FOXO3/DTX3L/MSN/SPTLC2/NUPR1/HIF1A/SESN1/LRP1/BNIP3L/TRIM38/HERPUD1 27 GO:1903053 regulation of extracellular matrix organization 8/502 48/18722 3.71167140448381e-05 0.000406876585714268 RUNX1/TNFRSF1B/RB1/CST3/COLGALT1/TNFRSF1A/TGFB1/LRP1 8 GO:0048659 smooth muscle cell proliferation 16/502 184/18722 3.78494876855467e-05 0.000413675628950855 MEF2C/IGF1/AIF1/APOE/TLR4/CYBA/NAMPT/JAK2/SOD2/TGFBR2/KLF4/TGFB1/STAT1/GNAI2/JUN/GNA13 16 GO:0010631 epithelial cell migration 24/502 357/18722 3.79157947849465e-05 0.000413675628950855 MEF2C/ZEB2/ENPP2/SPRED1/LGMN/TMSB4X/APOE/PLXND1/RIN2/ADAM9/GRN/NRP1/GLUL/TGFBR2/GPX1/KLF4/NR4A1/TGFB1/HIF1A/RTN4/SP100/PRCP/MACF1/RHOB 24 GO:0002260 lymphocyte homeostasis 9/502 62/18722 3.82518647398046e-05 0.000416360297144321 MEF2C/CD74/NCKAP1L/LGALS9/LYN/TNFSF13B/TSC22D3/HIF1A/SKIL 9 GO:0034284 response to monosaccharide 18/502 225/18722 3.8548659410116e-05 0.000418605864861964 GAS6/ICAM1/CYBA/HLA-DRB1/TXNIP/SLC8A1/NAMPT/SOD2/EGR1/XBP1/ATG7/GLUL/TGFBR2/UCP2/FOXO3/LGALS1/HIF1A/LRP1 18 GO:0097306 cellular response to alcohol 11/502 93/18722 3.87414881839853e-05 0.000419714576906595 CYBB/ITPR2/SPI1/PTGER4/KLF2/ABCA1/SOD2/FOXO3/KLF4/ADCY7/AHR 11 GO:0050678 regulation of epithelial cell proliferation 25/502 381/18722 3.91308668788477e-05 0.000422942500424181 MEF2C/CCL2/IGF1/EGFL7/APOE/CYBA/B2M/MTSS1/ZFP36L1/RB1/C5AR1/ZFP36/ALOX5/GRN/NRP1/XBP1/GLUL/GPX1/NR4A1/TGFB1/NUPR1/STAT1/STAT3/HIF1A/RTN4 25 GO:0042542 response to hydrogen peroxide 14/502 146/18722 3.93545045326193e-05 0.000424368153771321 TXNIP/ADAM9/KLF2/SLC8A1/SOD2/SIRPA/DUSP1/GPX1/FOXO3/KLF4/STAT1/SETX/JUN/RHOB 14 GO:0030224 monocyte differentiation 7/502 36/18722 4.06254739969577e-05 0.000436040470324655 CSF1R/CD4/CD74/IFI16/HLA-DRB1/ZFP36L1/JUN 7 GO:0046466 membrane lipid catabolic process 7/502 36/18722 4.06254739969577e-05 0.000436040470324655 ENPP2/ASAH1/PPT1/ACER3/FUCA1/MGST2/HEXA 7 GO:0035902 response to immobilization stress 6/502 25/18722 4.13835245921904e-05 0.000442788444488073 SLC8A1/FOS/HNMT/SOD2/ACTR2/FOXO3 6 GO:0071900 regulation of protein serine/threonine kinase activity 24/502 359/18722 4.14456109951007e-05 0.000442788444488073 CSF1R/PDGFC/APOE/TLR4/RB1/SYK/ADAM9/SLC8A1/LYN/ACTB/PYCARD/IQGAP1/DUSP1/TGFB1/DAZAP2/PTPN6/TAOK3/CCNL1/CAB39/CALM2/TAOK1/PRKAR1A/STK4/AKAP13 24 GO:0030316 osteoclast differentiation 11/502 94/18722 4.28334762660466e-05 0.000456561431351916 CSF1R/TYROBP/CCL3/MAFB/CCR1/TLR4/CD81/FOS/JUNB/ATP6AP1/PIK3R1 11 GO:0030500 regulation of bone mineralization 10/502 78/18722 4.31396084372788e-05 0.000457981651752879 MEF2C/CCL3/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 10 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 16/502 186/18722 4.31647211768818e-05 0.000457981651752879 CD4/CD74/CD36/BST2/TLR4/LGALS9/HLA-DRB1/MTDH/CLEC7A/TRIM22/LGALS1/TNFRSF1A/REL/LITAF/TRIM38/AKAP13 16 GO:0090132 epithelium migration 24/502 360/18722 4.33189987750033e-05 0.000458566792524406 MEF2C/ZEB2/ENPP2/SPRED1/LGMN/TMSB4X/APOE/PLXND1/RIN2/ADAM9/GRN/NRP1/GLUL/TGFBR2/GPX1/KLF4/NR4A1/TGFB1/HIF1A/RTN4/SP100/PRCP/MACF1/RHOB 24 GO:0050854 regulation of antigen receptor-mediated signaling pathway 9/502 63/18722 4.35815508838858e-05 0.000460292818239396 FCGR2B/LAPTM5/PTPRC/PRNP/LYN/CD81/CMTM3/PTPN6/DUSP3 9 GO:0008064 regulation of actin polymerization or depolymerization 16/502 187/18722 4.6061265322696e-05 0.000485097887244223 TMSB4X/PLEK/NCKAP1L/ICAM1/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 16 GO:0042326 negative regulation of phosphorylation 25/502 385/18722 4.64023351154959e-05 0.000485097887244223 SPRED1/APOE/SAMSN1/PTPRC/RB1/ARRB2/PRNP/PARP14/SLC8A1/LYN/SIRPA/PYCARD/DUSP1/ENG/SNX6/GADD45B/TGFB1/NUPR1/PTPN6/STAT3/DUSP3/LRP1/CALM2/ADAR/PRKAR1A 25 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 5/502 16/18722 4.64544669367036e-05 0.000485097887244223 CCL2/TLR4/NAMPT/JAK2/STAT1 5 GO:0071361 cellular response to ethanol 5/502 16/18722 4.64544669367036e-05 0.000485097887244223 CYBB/ITPR2/SPI1/SOD2/ADCY7 5 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 5/502 16/18722 4.64544669367036e-05 0.000485097887244223 CD84/LGALS9/SYK/CLEC7A/OAS1 5 GO:0046632 alpha-beta T cell differentiation 12/502 112/18722 4.70629499396958e-05 0.00049034505950683 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/RSAD2/SYK/PTGER4/TGFBR2/STAT3/NFKBIZ 12 GO:0045730 respiratory burst 7/502 37/18722 4.89570120648067e-05 0.000508932893959092 CYBB/NCF4/CYBA/GRN/CLEC7A/NCF2/NCF1 7 GO:0030832 regulation of actin filament length 16/502 188/18722 4.91278422666354e-05 0.000509563673375461 TMSB4X/PLEK/NCKAP1L/ICAM1/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 16 GO:0051098 regulation of binding 24/502 363/18722 4.940451700035e-05 0.000511287014862682 IGF1/TMSB4X/APOE/DAB2/PLXND1/CTSZ/IFI16/B2M/IFIT1/RB1/ARRB2/NRP1/ACTB/PARP9/JAK2/DTX3L/KLF4/TGFB1/TMBIM6/SP100/JUN/LRP1/CALM2/STK4 24 GO:0032507 maintenance of protein location in cell 9/502 64/18722 4.95251627359121e-05 0.000511391524143592 CD4/TMSB4X/SRGN/CCDC88A/VPS13C/TSPO/SP100/CHCHD10/GSN 9 GO:0045089 positive regulation of innate immune response 13/502 131/18722 5.16797971785954e-05 0.000532451540641832 TYROBP/TLR4/IFI16/HAVCR2/SPI1/SYK/HLA-E/LYN/CLEC7A/PARP9/PYCARD/PLSCR1/LAMP1 13 GO:0001570 vasculogenesis 10/502 80/18722 5.38143798854453e-05 0.000552628581889294 SPRED1/EGFL7/RIN2/ZFP36L1/JUNB/TGFBR2/QKI/ENG/TGFB1/CITED2 10 GO:0090130 tissue migration 24/502 365/18722 5.38771055841054e-05 0.000552628581889294 MEF2C/ZEB2/ENPP2/SPRED1/LGMN/TMSB4X/APOE/PLXND1/RIN2/ADAM9/GRN/NRP1/GLUL/TGFBR2/GPX1/KLF4/NR4A1/TGFB1/HIF1A/RTN4/SP100/PRCP/MACF1/RHOB 24 GO:0001933 negative regulation of protein phosphorylation 23/502 342/18722 5.44925507240816e-05 0.000557704733738057 SPRED1/APOE/SAMSN1/PTPRC/RB1/ARRB2/PRNP/PARP14/SLC8A1/LYN/SIRPA/PYCARD/DUSP1/ENG/SNX6/GADD45B/TGFB1/PTPN6/DUSP3/LRP1/CALM2/ADAR/PRKAR1A 23 GO:0055067 monovalent inorganic cation homeostasis 14/502 151/18722 5.7067949698076e-05 0.000582773367115452 SLC9A9/ATP1B1/GRN/SLC8A1/PDK4/DMXL2/ATP6V0A1/PPT1/ATP6AP2/GNAI2/DMXL1/SLC1A3/SLC4A7/ATP6AP1 14 GO:0070167 regulation of biomineral tissue development 11/502 97/18722 5.74164936992989e-05 0.000585041189103429 MEF2C/GAS6/CCL3/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 11 GO:0030833 regulation of actin filament polymerization 15/502 171/18722 5.94723176769369e-05 0.000604657014447275 TMSB4X/NCKAP1L/ICAM1/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 15 GO:0036293 response to decreased oxygen levels 22/502 322/18722 6.24226726960658e-05 0.000632275294345344 CYBB/ATP1B1/ICAM1/CYBA/ZFP36L1/RBPJ/ITPR2/NR4A2/MALAT1/SLC8A1/NAMPT/SOD2/CPEB4/SLC11A2/EGR1/TGFBR2/UCP2/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2 22 GO:0051924 regulation of calcium ion transport 19/502 255/18722 6.24621291646827e-05 0.000632275294345344 CCL2/CD4/ATP1B1/CCL3/CD84/CCR1/ICAM1/CYBA/CCL4/VMP1/ARRB2/PRNP/SLC8A1/LYN/TSPO/PTPN6/GNAI2/TMBIM6/CALM2 19 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 11/502 98/18722 6.31405774349156e-05 0.000637747404397205 CD74/HSPA1A/SOD2/XBP1/GPX1/CD44/MCL1/IVNS1ABP/HIF1A/TMBIM6/HERPUD1 11 GO:0032715 negative regulation of interleukin-6 production 9/502 66/18722 6.34804885619538e-05 0.000638392913233909 GAS6/CD84/NCKAP1L/TLR4/HAVCR2/ARRB2/KLF2/SIRPA/PTPN6 9 GO:0072678 T cell migration 9/502 66/18722 6.34804885619538e-05 0.000638392913233909 CCL2/CCL3/AIF1/ICAM1/CXCL16/TNFRSF14/PYCARD/MSN/ADAM10 9 GO:0010934 macrophage cytokine production 5/502 17/18722 6.43641254260078e-05 0.000640319234883252 CD74/CD36/LAPTM5/TLR4/TGFB1 5 GO:0010935 regulation of macrophage cytokine production 5/502 17/18722 6.43641254260078e-05 0.000640319234883252 CD74/CD36/LAPTM5/TLR4/TGFB1 5 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 5/502 17/18722 6.43641254260078e-05 0.000640319234883252 HLA-B/B2M/HLA-A/HLA-C/HLA-E 5 GO:0072673 lamellipodium morphogenesis 5/502 17/18722 6.43641254260078e-05 0.000640319234883252 ENPP2/PLEKHO1/CD44/ABI1/SNX2 5 GO:0090713 immunological memory process 5/502 17/18722 6.43641254260078e-05 0.000640319234883252 HLA-DRA/HLA-DRB1/CD81/FGL2/TNFRSF14 5 GO:0060333 interferon-gamma-mediated signaling pathway 6/502 27/18722 6.60903140174097e-05 0.000656081100095574 PARP14/PARP9/JAK2/IFNGR2/STAT1/SP100 6 GO:2000116 regulation of cysteine-type endopeptidase activity 18/502 235/18722 6.79790152913487e-05 0.00067338527781109 GAS6/LGMN/NAIP/LAPTM5/IFI16/LGALS9/SYK/ARRB2/CTSD/CLEC7A/JAK2/PYCARD/GPX1/CD44/KLF4/NR4A1/GSN/HERPUD1 18 GO:0022411 cellular component disassembly 27/502 443/18722 6.90591016098991e-05 0.000682552202773558 C1QA/C1QB/C1QC/CTSS/PLEK/ITGAM/VMP1/MCOLN1/CST3/LCP1/VPS13C/ATG7/TSPO/TGFB1/LAMP2/SETX/HIF1A/DUSP3/CAPG/CAPZA2/LRP1/BNIP3L/EPS8/PIK3R1/GSN/TAOK1/ADAM10 27 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 11/502 99/18722 6.93470677266693e-05 0.000682552202773558 CD74/IFI16/TNFRSF1B/ATM/PYCARD/CD44/TNFRSF1A/MCL1/NUPR1/PIK3R1/SKIL 11 GO:0110149 regulation of biomineralization 11/502 99/18722 6.93470677266693e-05 0.000682552202773558 MEF2C/GAS6/CCL3/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 11 GO:0008360 regulation of cell shape 14/502 154/18722 7.07473242393662e-05 0.000694855885204475 CSF1R/CCL2/CCL3/PLXND1/ITGB2/ICAM1/PLEKHO1/LST1/ARHGAP18/CYFIP1/MSN/RHOB/EPS8/PLXNB2 14 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 9/502 67/18722 7.16145205314037e-05 0.000701882991479393 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/CD81/TGFBR2/NFKBIZ 9 GO:0031669 cellular response to nutrient levels 17/502 215/18722 7.2718681016355e-05 0.000711197924696952 FOLR2/CD68/GAS6/ICAM1/IFI16/NAMPT/PDK4/CPEB4/XBP1/ATG7/GLUL/UCP2/FOXO3/LAMP2/SESN1/USF2/JUN 17 GO:0043367 CD4-positive, alpha-beta T cell differentiation 10/502 83/18722 7.40043106015716e-05 0.00072072408598499 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/RSAD2/PTGER4/STAT3/NFKBIZ 10 GO:0048678 response to axon injury 10/502 83/18722 7.40043106015716e-05 0.00072072408598499 SPP1/TYROBP/AIF1/GRN/LYN/JAK2/TSPO/LGALS1/KLF4/LRP1 10 GO:0007249 I-kappaB kinase/NF-kappaB signaling 20/502 281/18722 7.63396165416138e-05 0.0007419056010956 CD4/CD74/CD36/BST2/TLR4/TLR7/LGALS9/HLA-DRB1/MTDH/CLEC7A/SIRPA/PYCARD/TRIM22/LGALS1/TNFRSF1A/REL/STAT1/LITAF/TRIM38/AKAP13 20 GO:0043620 regulation of DNA-templated transcription in response to stress 8/502 53/18722 7.75300466484453e-05 0.000751895169383036 RBPJ/KLF2/HSPA1A/EGR1/HIF1A/TMBIM6/JUN/CITED2 8 GO:0046637 regulation of alpha-beta T cell differentiation 9/502 68/18722 8.06073650345393e-05 0.000780103913493261 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/SYK/TGFBR2/NFKBIZ 9 GO:0045445 myoblast differentiation 10/502 84/18722 8.20240104146484e-05 0.000789231866155221 MEF2C/IGF1/ZFP36L1/RB1/RBPJ/LGALS1/MBNL1/TGFB1/DDX17/DDX5 10 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 6/502 28/18722 8.22226991468932e-05 0.000789231866155221 FCER1G/HLA-B/B2M/HLA-A/HLA-C/HLA-E 6 GO:0002507 tolerance induction 6/502 28/18722 8.22226991468932e-05 0.000789231866155221 HLA-B/LGALS9/HAVCR2/HLA-E/LYN/TGFBR2 6 GO:0007266 Rho protein signal transduction 13/502 137/18722 8.22329787044567e-05 0.000789231866155221 LPAR6/APOE/ARHGAP4/ABCA1/NRP1/GPR65/WAS/ARHGDIB/MYO9B/RHOB/EPS8/GNA13/AKAP13 13 GO:0010543 regulation of platelet activation 7/502 40/18722 8.27044553619449e-05 0.00079047688120735 FCER1G/APOE/PLEK/TLR4/SYK/LYN/JAK2 7 GO:0150077 regulation of neuroinflammatory response 7/502 40/18722 8.27044553619449e-05 0.00079047688120735 IGF1/CCL3/CTSC/PTPRC/TNFRSF1B/GRN/NUPR1 7 GO:0006874 cellular calcium ion homeostasis 27/502 448/18722 8.33532730652361e-05 0.00079503554886553 LPAR6/C3AR1/ATP1B1/CMKLR1/CCL3/APOE/CD36/CCR1/CYBA/PTPRC/MCOLN1/ITPR2/FPR3/C5AR1/PTGER4/PRNP/FPR1/SLC8A1/LYN/JAK2/GPR65/PTPN6/TMBIM6/LRP1/CALM2/GNA13/HERPUD1 27 GO:0051403 stress-activated MAPK cascade 18/502 239/18722 8.44483832119961e-05 0.000803823499462334 FCGR2B/TLR4/TLR7/LGALS9/ZFP36L1/SPI1/ZFP36/PTGER4/CLEC7A/SIRPA/PYCARD/DUSP1/SDCBP/GADD45B/NCF1/DUSP3/TAOK3/TAOK1 18 GO:0030282 bone mineralization 12/502 119/18722 8.53779363089082e-05 0.000811002737915831 MEF2C/IGF1/CCL3/GPNMB/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 12 GO:0071248 cellular response to metal ion 16/502 197/18722 8.58929638120044e-05 0.000814223054496582 CYBB/MEF2C/LGMN/ALOX5AP/B2M/MCOLN1/PRNP/MEF2A/FOS/JUNB/IQGAP1/FOSB/TSPO/NCF1/ADCY7/JUN 16 GO:0034162 toll-like receptor 9 signaling pathway 5/502 18/18722 8.71621598888017e-05 0.000824564727291609 UNC93B1/RSAD2/PIK3AP1/HAVCR2/RTN4 5 GO:0072659 protein localization to plasma membrane 20/502 284/18722 8.83312219609899e-05 0.000833918842431713 ATP1B1/GAS6/DAB2/MYO5A/CCDC88A/PRNP/CD81/ACTB/EHD4/CLTC/TNFRSF1A/STX7/TGFB1/FCHO2/LRP1/MACF1/GOLGA4/PIK3R1/EFR3A/RAB8B 20 GO:0001667 ameboidal-type cell migration 28/502 475/18722 9.0392216697198e-05 0.000851638277884395 MEF2C/ZEB2/ENPP2/SPRED1/LGMN/TMSB4X/APOE/PLXND1/RIN2/ARHGAP4/ADAM9/GRN/SLC8A1/NRP1/GLUL/TGFBR2/GPX1/KLF4/NR4A1/TGFB1/ARHGDIB/TIMP1/HIF1A/RTN4/SP100/PRCP/MACF1/RHOB 28 GO:0031099 regeneration 16/502 198/18722 9.11851322766152e-05 0.000856593825952301 SPP1/IGF1/GAS6/RUNX1/C5AR1/NINJ1/LCP1/GRN/CD81/JAK2/TGFBR2/UCP2/GPX1/TSPO/KLF4/LRP1 16 GO:0009746 response to hexose 17/502 219/18722 9.12885335483105e-05 0.000856593825952301 GAS6/ICAM1/CYBA/HLA-DRB1/TXNIP/SLC8A1/NAMPT/EGR1/XBP1/ATG7/GLUL/TGFBR2/UCP2/FOXO3/LGALS1/HIF1A/LRP1 17 GO:0002887 negative regulation of myeloid leukocyte mediated immunity 4/502 10/18722 9.43243246528941e-05 0.00088150368857432 CD84/FCGR2B/LGALS9/SPI1 4 GO:0019062 virion attachment to host cell 4/502 10/18722 9.43243246528941e-05 0.00088150368857432 CD209/GAS6/ICAM1/CD81 4 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 23/502 355/18722 9.58409122601972e-05 0.000893871088942888 ZEB2/SPRED1/DAB2/RBPJ/SPI1/ARRB2/ADAM9/HSPA1A/FOS/JAK2/EGR1/TGFBR2/SDCBP/VIM/ENG/SNX6/TGFB1/STAT3/DDX5/JUN/LRP1/CITED2/SKIL 23 GO:0022604 regulation of cell morphogenesis 21/502 309/18722 9.82850029087761e-05 0.000914821777577461 CSF1R/CCL2/ENPP2/CCL3/PLXND1/ITGB2/ICAM1/PLEKHO1/LST1/NRP1/PREX1/ITSN2/ARHGAP18/ACTR2/CD44/CYFIP1/MSN/MACF1/RHOB/EPS8/PLXNB2 21 GO:0030593 neutrophil chemotaxis 11/502 103/18722 9.96811766140479e-05 0.0009259540622823 CCL2/C3AR1/FCER1G/CCL3/CD74/NCKAP1L/ITGB2/CCL4/SYK/C5AR1/PREX1 11 GO:0051047 positive regulation of secretion 21/502 310/18722 0.000102856040750936 0.000953531151330321 SPP1/IGF1/ITGB2/TLR4/CYBA/ITGAM/HLA-DRB1/ITSN1/SYK/ADAM9/JAK2/XBP1/GLUL/SDCBP/LAMP1/TGFB1/GNAI2/HIF1A/LRP1/ATP6AP1/RAB8B 21 GO:1990266 neutrophil migration 12/502 122/18722 0.000108640281888379 0.00100486674462041 CCL2/C3AR1/FCER1G/CCL3/CD74/NCKAP1L/ITGB2/CCL4/SYK/C5AR1/PECAM1/PREX1 12 GO:0048661 positive regulation of smooth muscle cell proliferation 11/502 104/18722 0.000108827980772768 0.00100486674462041 IGF1/AIF1/TLR4/CYBA/NAMPT/JAK2/TGFBR2/TGFB1/STAT1/GNAI2/JUN 11 GO:0045766 positive regulation of angiogenesis 15/502 181/18722 0.000113278442765247 0.00103941339398125 CYBB/C3AR1/RUNX1/C5AR1/NINJ1/GRN/MTDH/NRP1/XBP1/TGFBR2/ENG/KLF4/STAT3/HIF1A/RHOB 15 GO:0097696 receptor signaling pathway via STAT 15/502 181/18722 0.000113278442765247 0.00103941339398125 CSF1R/CCL2/IGF1/PTPRC/IL10RA/PARP14/LYN/PARP9/JAK2/TNFRSF1A/TGFB1/STAT1/STAT3/STAT2/IFNAR1 15 GO:1904018 positive regulation of vasculature development 15/502 181/18722 0.000113278442765247 0.00103941339398125 CYBB/C3AR1/RUNX1/C5AR1/NINJ1/GRN/MTDH/NRP1/XBP1/TGFBR2/ENG/KLF4/STAT3/HIF1A/RHOB 15 GO:0061515 myeloid cell development 9/502 71/18722 0.000113468172062372 0.00103941339398125 TYROBP/NCKAP1L/KLF2/SLC11A2/EVI2B/PTPN6/ABI1/CITED2/ATP6AP1 9 GO:0036294 cellular response to decreased oxygen levels 14/502 161/18722 0.000114252073199916 0.00104260569782668 CYBB/ICAM1/ZFP36L1/RBPJ/MALAT1/SLC8A1/NAMPT/CPEB4/EGR1/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2 14 GO:0030890 positive regulation of B cell proliferation 7/502 42/18722 0.000114267420838333 0.00104260569782668 MEF2C/CD74/NCKAP1L/TLR4/PTPRC/CD81/TNFSF13B 7 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 5/502 19/18722 0.000115695050646904 0.00105355374860743 TYROBP/ITGB2/ITGAM/SPI1/HLA-E 5 GO:0030168 platelet activation 12/502 123/18722 0.000117516027088886 0.00106803367645027 FCER1G/APOE/PLEK/TLR4/SYK/LYN/ACTB/RAP2B/FERMT3/JAK2/PLSCR1/PTPN6 12 GO:0070168 negative regulation of biomineral tissue development 6/502 30/18722 0.000123829397847571 0.00112320547929973 GAS6/CCL3/CCR1/SRGN/TGFB1/HIF1A 6 GO:0010632 regulation of epithelial cell migration 20/502 292/18722 0.000128853471658839 0.00116603146513608 MEF2C/ENPP2/SPRED1/LGMN/TMSB4X/APOE/RIN2/ADAM9/GRN/NRP1/GLUL/TGFBR2/KLF4/TGFB1/HIF1A/RTN4/SP100/PRCP/MACF1/RHOB 20 GO:0055074 calcium ion homeostasis 27/502 460/18722 0.000129054930858123 0.00116603146513608 LPAR6/C3AR1/ATP1B1/CMKLR1/CCL3/APOE/CD36/CCR1/CYBA/PTPRC/MCOLN1/ITPR2/FPR3/C5AR1/PTGER4/PRNP/FPR1/SLC8A1/LYN/JAK2/GPR65/PTPN6/TMBIM6/LRP1/CALM2/GNA13/HERPUD1 27 GO:0031952 regulation of protein autophosphorylation 7/502 43/18722 0.000133366888674722 0.00120030199807249 PDGFC/GPNMB/PTPRC/RAP2B/IQGAP1/ENG/CALM2 7 GO:0034142 toll-like receptor 4 signaling pathway 7/502 43/18722 0.000133366888674722 0.00120030199807249 CD14/LY96/TLR4/PIK3AP1/NINJ1/LYN/OAS1 7 GO:0050673 epithelial cell proliferation 26/502 437/18722 0.000138174409046197 0.00124115498300525 MEF2C/CCL2/IGF1/EGFL7/IGFBP4/APOE/CYBA/B2M/MTSS1/ZFP36L1/RB1/C5AR1/ZFP36/ALOX5/GRN/NRP1/XBP1/GLUL/GPX1/NR4A1/TGFB1/NUPR1/STAT1/STAT3/HIF1A/RTN4 26 GO:0007229 integrin-mediated signaling pathway 11/502 107/18722 0.000140682504455984 0.00126123501087864 PLEK/ITGB2/ITGAM/SYK/ADAM9/NRP1/ISG15/CD63/FERMT3/TIMP1/ADAM10 11 GO:0002637 regulation of immunoglobulin production 9/502 73/18722 0.000141080543979446 0.00126183178974544 CD28/CR1/FCGR2B/PTPRC/CD86/HLA-E/XBP1/TGFB1/TMBIM6 9 GO:0046777 protein autophosphorylation 17/502 227/18722 0.000141294610265486 0.00126183178974544 CSF1R/PDGFC/GPNMB/PTPRC/MKNK1/PEAK1/SYK/LYN/RAP2B/JAK2/ATM/IQGAP1/ENG/TAOK3/CALM2/TAOK1/STK4 17 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 18/502 249/18722 0.000141921345112854 0.00126498678707526 CD4/CD74/CD36/BST2/TLR4/LGALS9/HLA-DRB1/MTDH/CLEC7A/PYCARD/TRIM22/LGALS1/TNFRSF1A/REL/STAT1/LITAF/TRIM38/AKAP13 18 GO:0002604 regulation of dendritic cell antigen processing and presentation 4/502 11/18722 0.000145085615004149 0.00128575872607125 CD68/FCGR2B/CD74/FGL2 4 GO:0043312 neutrophil degranulation 4/502 11/18722 0.000145085615004149 0.00128575872607125 ITGB2/ITGAM/SPI1/SYK 4 GO:0098883 synapse pruning 4/502 11/18722 0.000145085615004149 0.00128575872607125 C1QA/C1QB/C1QC/ITGAM 4 GO:0097581 lamellipodium organization 10/502 90/18722 0.000147293370806788 0.00130282817084551 ENPP2/CCDC88A/PLEKHO1/ACTR2/CD44/CYFIP1/WAS/ABI1/PIK3R1/SNX2 10 GO:0001782 B cell homeostasis 6/502 31/18722 0.000150099341800246 0.00132188221503848 MEF2C/CD74/NCKAP1L/LYN/TNFSF13B/HIF1A 6 GO:0110150 negative regulation of biomineralization 6/502 31/18722 0.000150099341800246 0.00132188221503848 GAS6/CCL3/CCR1/SRGN/TGFB1/HIF1A 6 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 5/502 20/18722 0.00015087630988766 0.00132188221503848 SAMHD1/ISG15/OAS1/STAT2/ADAR 5 GO:0072567 chemokine (C-X-C motif) ligand 2 production 5/502 20/18722 0.00015087630988766 0.00132188221503848 CD74/TLR4/OAS1/KLF4/LRP1 5 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 5/502 20/18722 0.00015087630988766 0.00132188221503848 CD74/TLR4/OAS1/KLF4/LRP1 5 GO:0051090 regulation of DNA-binding transcription factor activity 26/502 440/18722 0.00015405149317681 0.00134714973050269 GAS6/TMIGD3/CMKLR1/TMSB4X/CD36/ICAM1/TLR4/LGALS9/RB1/HAVCR2/SPI1/SYK/ARRB2/HSPA1A/PRNP/MTDH/CLEC7A/JAK2/PYCARD/TRIM22/SGK1/KLF4/NUPR1/STAT3/SP100/TRIM38 26 GO:0042269 regulation of natural killer cell mediated cytotoxicity 7/502 44/18722 0.000154975347798332 0.00134758638893812 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E/LAMP1 7 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 7/502 44/18722 0.000154975347798332 0.00134758638893812 TLR4/CYBA/RSAD2/NINJ1/HSPA1A/SLC15A3/RTN4 7 GO:0150076 neuroinflammatory response 7/502 44/18722 0.000154975347798332 0.00134758638893812 IGF1/CCL3/CTSC/PTPRC/TNFRSF1B/GRN/NUPR1 7 GO:0003151 outflow tract morphogenesis 9/502 74/18722 0.0001568623758288 0.00136143592980118 MEF2C/PLXND1/RBPJ/NRP1/TGFBR2/ENG/DHRS3/HIF1A/CITED2 9 GO:0006885 regulation of pH 10/502 91/18722 0.000161581812239044 0.00139977053074497 SLC9A9/GRN/PDK4/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1/SLC4A7/ATP6AP1 10 GO:0009896 positive regulation of catabolic process 28/502 492/18722 0.000163242148962892 0.00141151061888288 IGF1/APOE/DAB2/LAPTM5/CTSC/TNFRSF1B/ZFP36L1/ZFP36/ADAM9/WWP1/HSPA1A/MTDH/CD81/TRIM22/BTG2/ATG7/ZFP36L2/FOXO3/DTX3L/MSN/SPTLC2/NUPR1/HIF1A/SESN1/LRP1/BNIP3L/TRIM38/HERPUD1 28 GO:0031960 response to corticosteroid 14/502 167/18722 0.000168394710264137 0.00145334688373488 CYBB/AIF1/ICAM1/CYBA/ZFP36L1/ZFP36/ADAM9/FOS/HNMT/DUSP1/ZFP36L2/ENG/FOXO3/FOSB 14 GO:0031647 regulation of protein stability 20/502 298/18722 0.000169243165252582 0.00145794950178482 IGF1/ATP1B1/TYROBP/MFSD1/GRN/HSPA1A/PRNP/CD81/PYCARD/RNF149/LAMP1/CREBL2/LAMP2/RTN4/ATF7IP/PIK3R1/GSN/STX12/STK4/GLMP 20 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 16/502 209/18722 0.000171155463159608 0.00147168247690771 GAS6/NAIP/LAPTM5/LGALS9/SYK/ARRB2/CTSD/CLEC7A/JAK2/PYCARD/GPX1/CD44/KLF4/NR4A1/GSN/HERPUD1 16 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 12/502 128/18722 0.000171831584819117 0.00147475493761268 FCGR2B/TLR4/SPI1/LYN/CLEC7A/PYCARD/SDCBP/GADD45B/RNF13/NCF1/TAOK3/TAOK1 12 GO:0002292 T cell differentiation involved in immune response 9/502 75/18722 0.000174089357383936 0.00149136549492239 FCER1G/LGALS9/HLA-DRA/HLA-DRB1/CD86/PTGER4/FGL2/STAT3/NFKBIZ 9 GO:0002920 regulation of humoral immune response 7/502 45/18722 0.000179332586174415 0.00153344277937679 VSIG4/A2M/CR1/FCGR2B/PTPRC/SERPING1/PTPN6 7 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 6/502 32/18722 0.000180590015091765 0.00153850720039504 NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/NFKBIZ 6 GO:0050850 positive regulation of calcium-mediated signaling 6/502 32/18722 0.000180590015091765 0.00153850720039504 IGF1/CD4/CCL3/CCL4/SYK/CLEC7A 6 GO:0010975 regulation of neuron projection development 26/502 445/18722 0.000184149441578488 0.00156594727342295 SPP1/PMP22/APOE/PLXND1/CTSZ/B2M/ARHGAP4/CCDC88A/GRN/NRP1/LYN/PREX1/IQGAP1/VIM/ACTR2/LGALS1/CYFIP1/KLF4/SETX/RTN4/LRP1/MACF1/GOLGA4/SKIL/ADAM10/PLXNB2 26 GO:0031214 biomineral tissue development 14/502 169/18722 0.000190796319006089 0.00161729819612016 SPP1/MEF2C/IGF1/GAS6/CCL3/GPNMB/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 14 GO:0051592 response to calcium ion 13/502 149/18722 0.000192321177971506 0.00161729819612016 MEF2C/LGMN/ALOX5AP/TXNIP/MCOLN1/ADAM9/MEF2A/FOS/JUNB/IQGAP1/DUSP1/FOSB/CALM2 13 GO:0007160 cell-matrix adhesion 17/502 233/18722 0.000193165679716121 0.00161729819612016 LYVE1/SIGLEC1/CD36/ITGB2/RIN2/PEAK1/ADAM9/NRP1/CD63/FERMT3/IQGAP1/CD44/PLEKHA2/DUSP3/LRP1/MACF1/PIK3R1 17 GO:0044766 multi-organism transport 5/502 21/18722 0.000193684219768821 0.00161729819612016 SIGLEC1/CD209/BST2/IFIT1/EPS15 5 GO:0045655 regulation of monocyte differentiation 5/502 21/18722 0.000193684219768821 0.00161729819612016 CD4/CD74/HLA-DRB1/ZFP36L1/JUN 5 GO:0051767 nitric-oxide synthase biosynthetic process 5/502 21/18722 0.000193684219768821 0.00161729819612016 CCL2/TLR4/NAMPT/JAK2/STAT1 5 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 5/502 21/18722 0.000193684219768821 0.00161729819612016 CCL2/TLR4/NAMPT/JAK2/STAT1 5 GO:0071605 monocyte chemotactic protein-1 production 5/502 21/18722 0.000193684219768821 0.00161729819612016 CD84/LGALS9/SYK/CLEC7A/OAS1 5 GO:0071637 regulation of monocyte chemotactic protein-1 production 5/502 21/18722 0.000193684219768821 0.00161729819612016 CD84/LGALS9/SYK/CLEC7A/OAS1 5 GO:1902579 multi-organism localization 5/502 21/18722 0.000193684219768821 0.00161729819612016 SIGLEC1/CD209/BST2/IFIT1/EPS15 5 GO:0009749 response to glucose 16/502 212/18722 0.00020150969258345 0.00167961051872259 GAS6/ICAM1/CYBA/HLA-DRB1/TXNIP/SLC8A1/EGR1/XBP1/ATG7/GLUL/TGFBR2/UCP2/FOXO3/LGALS1/HIF1A/LRP1 16 GO:0007259 receptor signaling pathway via JAK-STAT 14/502 170/18722 0.000202929608211802 0.00168840353882697 CSF1R/CCL2/IGF1/PTPRC/IL10RA/PARP14/LYN/PARP9/JAK2/TNFRSF1A/STAT1/STAT3/STAT2/IFNAR1 14 GO:0050821 protein stabilization 15/502 191/18722 0.000205356005729756 0.00170552402604282 IGF1/ATP1B1/TYROBP/MFSD1/GRN/HSPA1A/LAMP1/CREBL2/LAMP2/RTN4/ATF7IP/PIK3R1/STX12/STK4/GLMP 15 GO:0045851 pH reduction 7/502 46/18722 0.000206692233055232 0.00171047991075761 GRN/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1/ATP6AP1 7 GO:0061462 protein localization to lysosome 7/502 46/18722 0.000206692233055232 0.00171047991075761 LAPTM5/MFSD1/CD81/LAMP2/NCOA4/RTN4/GLMP 7 GO:0044650 adhesion of symbiont to host cell 4/502 12/18722 0.000213024722967655 0.00175035944662233 CD209/GAS6/ICAM1/CD81 4 GO:0045916 negative regulation of complement activation 4/502 12/18722 0.000213024722967655 0.00175035944662233 VSIG4/A2M/CR1/SERPING1 4 GO:0060907 positive regulation of macrophage cytokine production 4/502 12/18722 0.000213024722967655 0.00175035944662233 CD74/CD36/LAPTM5/TLR4 4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 4/502 12/18722 0.000213024722967655 0.00175035944662233 HSPA1A/TMBIM6/JUN/CITED2 4 GO:2000401 regulation of lymphocyte migration 8/502 61/18722 0.000213594849793413 0.00175193222543321 CCL2/CCL3/AIF1/CCL4/TNFRSF14/PYCARD/MSN/ADAM10 8 GO:0110148 biomineralization 14/502 171/18722 0.000215721978068413 0.00175729437049808 SPP1/MEF2C/IGF1/GAS6/CCL3/GPNMB/CCR1/BMP2K/SRGN/ALOX5/SLC8A1/ISG15/TGFB1/HIF1A 14 GO:0002431 Fc receptor mediated stimulatory signaling pathway 6/502 33/18722 0.000215768093913296 0.00175729437049808 FCER1G/FCGR2B/PTPRC/SYK/LYN/PLSCR1 6 GO:0036336 dendritic cell migration 6/502 33/18722 0.000215768093913296 0.00175729437049808 GAS6/CCR1/LGALS9/SPI1/ALOX5/EPS8 6 GO:0045920 negative regulation of exocytosis 6/502 33/18722 0.000215768093913296 0.00175729437049808 CD84/FCGR2B/NCKAP1L/LGALS9/SPI1/GNAI2 6 GO:0031623 receptor internalization 11/502 113/18722 0.00022860734680933 0.00185858978267128 FCER1G/CD36/ITGB2/SYK/ARRB2/CD81/CLTC/CD63/EPS15/SDCBP/LRP1 11 GO:1901136 carbohydrate derivative catabolic process 14/502 172/18722 0.000229202682516813 0.00186016071811014 LYVE1/ALDH1A1/MAN1A1/CST3/SAMHD1/TYMP/CD44/TGFB1/GNS/FUCA1/NPL/MGAT1/GNPDA1/HEXA 14 GO:0007565 female pregnancy 15/502 193/18722 0.000230044249642671 0.00186372101374255 SPP1/CTSB/LGALS9/VMP1/HAVCR2/FOS/JUNB/NAMPT/TGFBR2/UCP2/FOSB/ARHGDIB/TIMP1/ADCY7/CITED2 15 GO:0051099 positive regulation of binding 14/502 173/18722 0.000243401946516706 0.00196849196605993 IGF1/APOE/PLXND1/B2M/RB1/NRP1/PARP9/JAK2/DTX3L/KLF4/TGFB1/LRP1/CALM2/STK4 14 GO:0007041 lysosomal transport 11/502 114/18722 0.000247033311045452 0.00199437364205281 LAPTM5/DENND3/PSAP/GRN/HSPA1A/DTX3L/LAMP1/LAMP2/NCOA4/LRP1/RHOB 11 GO:0051259 protein complex oligomerization 17/502 238/18722 0.000248369465189759 0.00200166750168611 KCTD12/CD74/ALOX5AP/B2M/HLA-DRB1/MCOLN1/SAMHD1/NINJ1/PRNP/RNF213/ISG15/EHD4/SOD2/PYCARD/GLS/MAT2A/STK4 17 GO:0001666 response to hypoxia 20/502 307/18722 0.000250712053432571 0.00201703297248535 CYBB/ATP1B1/ICAM1/CYBA/ZFP36L1/RBPJ/ITPR2/NR4A2/MALAT1/SLC8A1/SOD2/SLC11A2/EGR1/TGFBR2/UCP2/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2 20 GO:1901655 cellular response to ketone 10/502 96/18722 0.000251766552015874 0.00201849578791236 SPP1/GAS6/ICAM1/PTGER4/KLF2/FOXO3/KLF4/MSN/NCOA4/AHR 10 GO:1904035 regulation of epithelial cell apoptotic process 10/502 96/18722 0.000251766552015874 0.00201849578791236 CCL2/GAS6/ICAM1/ZFP36L1/ZFP36/ARRB2/JAK2/FOXO3/NUPR1/GSN 10 GO:0032743 positive regulation of interleukin-2 production 6/502 34/18722 0.000256127640789617 0.00204990738112936 CD4/CD28/RUNX1/PTPRC/CD86/CLEC7A 6 GO:0070302 regulation of stress-activated protein kinase signaling cascade 15/502 195/18722 0.000257256270784032 0.00205538429818123 FCGR2B/TLR4/SPI1/LYN/CLEC7A/SIRPA/PYCARD/DUSP1/SDCBP/GADD45B/RNF13/NCF1/DUSP3/TAOK3/TAOK1 15 GO:0001659 temperature homeostasis 14/502 174/18722 0.000258350984513585 0.00205702522265034 GATM/CMKLR1/PDGFC/CD36/TLR4/ALDH1A1/RB1/RBPJ/SYK/JAK2/EGR1/UCP2/GPX1/STAT3 14 GO:0007584 response to nutrient 14/502 174/18722 0.000258350984513585 0.00205702522265034 SPP1/FOLR2/CYBB/C2/GAS6/ABCA1/SLC8A1/SOD2/XBP1/TGFBR2/TSPO/STAT1/GNAI2/USF2 14 GO:0010466 negative regulation of peptidase activity 18/502 262/18722 0.000266183851273256 0.00211574999311011 A2M/GAS6/CR1/NAIP/BST2/IFI16/TIMP2/CST3/SERPING1/ARRB2/PRNP/GPX1/CD44/KLF4/NR4A1/TIMP1/LRP1/HERPUD1 18 GO:0002715 regulation of natural killer cell mediated immunity 7/502 48/18722 0.000271503269517788 0.00215432954509312 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E/LAMP1 7 GO:1990778 protein localization to cell periphery 21/502 333/18722 0.000275278671779436 0.00218054646515697 ATP1B1/GAS6/DAB2/MYO5A/CCDC88A/PRNP/CD81/ACTB/EHD4/CLTC/TNFRSF1A/STX7/TGFB1/FCHO2/LRP1/MACF1/GOLGA4/PIK3R1/EFR3A/ADAM10/RAB8B 21 GO:1902882 regulation of response to oxidative stress 10/502 98/18722 0.000298078941649583 0.00235711655396747 CD36/TLR4/ALOX5/SOD2/ATG7/GPX1/FOXO3/MCL1/HIF1A/SESN1 10 GO:0045670 regulation of osteoclast differentiation 8/502 64/18722 0.000299301239756292 0.00235871811773868 TYROBP/CCL3/MAFB/CCR1/TLR4/FOS/ATP6AP1/PIK3R1 8 GO:1903409 reactive oxygen species biosynthetic process 8/502 64/18722 0.000299301239756292 0.00235871811773868 CD36/TLR4/CYBA/ALOX5/SOD2/FOXO3/NCF1/STAT3 8 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 4/502 13/18722 0.00030119910630857 0.00236561471270534 RBPJ/EGR1/HIF1A/CITED2 4 GO:1903054 negative regulation of extracellular matrix organization 4/502 13/18722 0.00030119910630857 0.00236561471270534 TNFRSF1B/CST3/TNFRSF1A/TGFB1 4 GO:2000403 positive regulation of lymphocyte migration 6/502 35/18722 0.00030218985628161 0.00236937334772666 CCL3/AIF1/CCL4/TNFRSF14/PYCARD/ADAM10 6 GO:0019932 second-messenger-mediated signaling 20/502 312/18722 0.00030941645704841 0.00241838551186981 IGF1/CD4/ATP1B1/CMKLR1/CCL3/APOE/CD36/PLEK/CCR1/PTPRC/CCL4/MCOLN1/ITPR2/SYK/PRNP/FPR1/SLC8A1/CLEC7A/AHR/CALM2 20 GO:0030225 macrophage differentiation 7/502 49/18722 0.00030953219736705 0.00241838551186981 C1QC/CSF1R/CD4/HLA-DRB1/RB1/SPI1/TGFB1 7 GO:0072676 lymphocyte migration 11/502 117/18722 0.000310009210665541 0.00241838551186981 CCL2/GAS6/CCL3/AIF1/ICAM1/CCL4/CXCL16/TNFRSF14/PYCARD/MSN/ADAM10 11 GO:0072503 cellular divalent inorganic cation homeostasis 27/502 486/18722 0.000311764650324082 0.00242798530706936 LPAR6/C3AR1/ATP1B1/CMKLR1/CCL3/APOE/CD36/CCR1/CYBA/PTPRC/MCOLN1/ITPR2/FPR3/C5AR1/PTGER4/PRNP/FPR1/SLC8A1/LYN/JAK2/GPR65/PTPN6/TMBIM6/LRP1/CALM2/GNA13/HERPUD1 27 GO:0030641 regulation of cellular pH 9/502 81/18722 0.000313854125085246 0.00244014988679723 SLC9A9/GRN/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1/SLC4A7/ATP6AP1 9 GO:0002312 B cell activation involved in immune response 9/502 82/18722 0.000344330068229563 0.00266584588364221 CD28/CR1/FCGR2B/TLR4/PTPRC/SPI1/XBP1/LGALS1/TGFB1 9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 9/502 82/18722 0.000344330068229563 0.00266584588364221 ICAM1/SPI1/GPX1/TNFRSF1A/SP100/FEM1B/PIK3R1/SKIL/STK4 9 GO:0031589 cell-substrate adhesion 22/502 363/18722 0.000344612157029409 0.00266584588364221 LYVE1/SIGLEC1/GAS6/CD36/ITGB2/RIN2/PEAK1/ADAM9/NRP1/PREX1/CD63/FERMT3/JAK2/IQGAP1/CD44/LGALS1/PLEKHA2/DUSP3/LRP1/MACF1/PIK3R1/STK4 22 GO:0001961 positive regulation of cytokine-mediated signaling pathway 7/502 50/18722 0.000351718717976649 0.00271175131559996 GAS6/CD74/LAPTM5/HSPA1A/PARP14/PARP9/HIF1A 7 GO:0038093 Fc receptor signaling pathway 7/502 50/18722 0.000351718717976649 0.00271175131559996 FCER1G/FCGR2B/PTPRC/FCGR1B/SYK/LYN/MAP3K1 7 GO:0060338 regulation of type I interferon-mediated signaling pathway 6/502 36/18722 0.000354502732738541 0.00272866828893259 SAMHD1/ISG15/OAS1/PTPN6/STAT2/ADAR 6 GO:0043434 response to peptide hormone 24/502 414/18722 0.000361492775994165 0.00277784980356978 CYBB/ICAM1/CYBA/MYO5A/ZFP36L1/NR4A2/LYN/JAK2/VPS13C/PDK4/EGR1/XBP1/BTG2/IQGAP1/UCP2/CYFIP1/NR4A1/STAT1/TIMP1/STAT3/GNAI2/STAT2/PIK3R1/RAB8B 24 GO:0019722 calcium-mediated signaling 15/502 202/18722 0.00037551968403867 0.00288085250143099 IGF1/CD4/ATP1B1/CMKLR1/CCL3/PLEK/CCR1/PTPRC/CCL4/MCOLN1/SYK/PRNP/SLC8A1/CLEC7A/CALM2 15 GO:0051043 regulation of membrane protein ectodomain proteolysis 5/502 24/18722 0.000378565403987734 0.0028946174526401 APOE/TNFRSF1B/TIMP2/ADAM9/TIMP1 5 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 5/502 24/18722 0.000378565403987734 0.0028946174526401 CD36/TLR4/CYBA/SOD2/FOXO3 5 GO:0050830 defense response to Gram-positive bacterium 10/502 101/18722 0.000380748870971879 0.00290650870811207 MPEG1/CD36/RNASE6/HLA-A/HAVCR2/C5AR1/HLA-E/TNFRSF14/PYCARD/ACP5 10 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 7/502 51/18722 0.000398387063452657 0.0030361425956046 RUNX1/NCKAP1L/LGALS9/HLA-DRA/HLA-DRB1/CD86/NFKBIZ 7 GO:0070527 platelet aggregation 8/502 67/18722 0.000411212727426115 0.00311337214316819 PLEK/SYK/LYN/ACTB/RAP2B/FERMT3/JAK2/PTPN6 8 GO:0072665 protein localization to vacuole 8/502 67/18722 0.000411212727426115 0.00311337214316819 LAPTM5/MFSD1/CD81/VPS13C/LAMP2/NCOA4/RTN4/GLMP 8 GO:0034616 response to laminar fluid shear stress 4/502 14/18722 0.00041277464768052 0.00311337214316819 ADAM9/KLF2/ABCA1/KLF4 4 GO:0044764 multi-organism cellular process 4/502 14/18722 0.00041277464768052 0.00311337214316819 SIGLEC1/GAS6/FCHSD2/EPS15 4 GO:0046348 amino sugar catabolic process 4/502 14/18722 0.00041277464768052 0.00311337214316819 ALDH1A1/NPL/MGAT1/GNPDA1 4 GO:0051764 actin crosslink formation 4/502 14/18722 0.00041277464768052 0.00311337214316819 MARCKS/AIF1/LCP1/EPS8 4 GO:0071241 cellular response to inorganic substance 16/502 226/18722 0.000413231840878787 0.00311337214316819 CYBB/MEF2C/LGMN/ALOX5AP/B2M/MCOLN1/PRNP/MEF2A/FOS/JUNB/IQGAP1/FOSB/TSPO/NCF1/ADCY7/JUN 16 GO:0060348 bone development 15/502 205/18722 0.000438977579117072 0.00330196793657817 MEF2C/IGF1/TYROBP/PDGFC/PTPRC/PTGER4/TGFBR2/ENG/ACP5/DHRS3/PTPN6/ABI1/CITED2/ATP6AP1/AKAP13 15 GO:0002218 activation of innate immune response 7/502 52/18722 0.000449875630054422 0.00337297352452473 TYROBP/TLR4/IFI16/SYK/LYN/CLEC7A/PYCARD 7 GO:1903426 regulation of reactive oxygen species biosynthetic process 7/502 52/18722 0.000449875630054422 0.00337297352452473 CD36/TLR4/CYBA/ALOX5/SOD2/FOXO3/STAT3 7 GO:0071277 cellular response to calcium ion 9/502 85/18722 0.00045074461552107 0.00337402037443442 MEF2C/LGMN/ALOX5AP/MCOLN1/MEF2A/FOS/JUNB/IQGAP1/FOSB 9 GO:0042267 natural killer cell mediated cytotoxicity 8/502 68/18722 0.00045529344241166 0.00340256456316048 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E/LAMP1/PTPN6 8 GO:0071322 cellular response to carbohydrate stimulus 13/502 163/18722 0.000462067898000502 0.00344762273572633 GAS6/ICAM1/CYBA/HLA-DRB1/ZFP36L1/CLEC7A/XBP1/UCP2/FOXO3/LGALS1/HIF1A/COLEC12/LRP1 13 GO:0045444 fat cell differentiation 16/502 229/18722 0.000477761267595573 0.00355399913960119 CMKLR1/MAFB/METRNL/ZFP36L1/NR4A2/ZFP36/ALOX5/XBP1/ZFP36L2/GPX1/KLF4/NR4A1/TGFB1/CREBL2/ATF5/STK4 16 GO:0070555 response to interleukin-1 12/502 143/18722 0.000479453534467025 0.00355399913960119 CCL2/CCL3/ICAM1/CYBA/LGALS9/CCL4/KLF2/HNMT/SIRPA/PYCARD/EGR1/HIF1A 12 GO:0030279 negative regulation of ossification 6/502 38/18722 0.000480203666458861 0.00355399913960119 MEF2C/CCL3/CCR1/SRGN/RBPJ/HIF1A 6 GO:0048246 macrophage chemotaxis 6/502 38/18722 0.000480203666458861 0.00355399913960119 CSF1R/CCL2/C3AR1/CMKLR1/CCL3/C5AR1 6 GO:0045862 positive regulation of proteolysis 22/502 372/18722 0.000480689141504248 0.00355399913960119 CR1/LGMN/APOE/DAB2/LAPTM5/IFI16/CTSC/LGALS9/TNFRSF1B/SYK/ADAM9/GRN/HSPA1A/CTSD/LYN/CLEC7A/JAK2/PYCARD/NUPR1/STAT3/GSN/HERPUD1 22 GO:0032963 collagen metabolic process 10/502 104/18722 0.000481679312169862 0.00355399913960119 RUNX1/CTSS/CTSB/CST3/ARRB2/VIM/ENG/PEPD/TGFB1/HIF1A 10 GO:0010951 negative regulation of endopeptidase activity 17/502 252/18722 0.000481702866521821 0.00355399913960119 A2M/GAS6/CR1/NAIP/BST2/IFI16/TIMP2/CST3/SERPING1/ARRB2/PRNP/GPX1/CD44/KLF4/NR4A1/TIMP1/HERPUD1 17 GO:0034103 regulation of tissue remodeling 9/502 86/18722 0.000491706689463758 0.00360481005619547 SPP1/CSF1R/RUNX1/GPNMB/CST3/SYK/PDK4/TGFB1/ATP6AP1 9 GO:0035023 regulation of Rho protein signal transduction 9/502 86/18722 0.000491706689463758 0.00360481005619547 LPAR6/APOE/ABCA1/NRP1/GPR65/ARHGDIB/MYO9B/EPS8/AKAP13 9 GO:0060761 negative regulation of response to cytokine stimulus 9/502 86/18722 0.000491706689463758 0.00360481005619547 GAS6/PTPRC/SAMHD1/PARP14/ISG15/OAS1/KLF4/STAT2/ADAR 9 GO:2000117 negative regulation of cysteine-type endopeptidase activity 9/502 86/18722 0.000491706689463758 0.00360481005619547 GAS6/NAIP/IFI16/ARRB2/GPX1/CD44/KLF4/NR4A1/HERPUD1 9 GO:0062207 regulation of pattern recognition receptor signaling pathway 10/502 105/18722 0.00051988966453347 0.00380539491793012 CD36/TLR4/CYBA/RSAD2/ARRB2/NINJ1/HSPA1A/SLC15A3/LYN/RTN4 10 GO:0001776 leukocyte homeostasis 9/502 87/18722 0.000535675243605333 0.00391474514521053 MEF2C/CD74/NCKAP1L/LGALS9/LYN/TNFSF13B/TSC22D3/HIF1A/SKIL 9 GO:0051056 regulation of small GTPase mediated signal transduction 19/502 302/18722 0.000545794125730685 0.00398240319500024 LPAR6/IGF1/CYTH4/APOE/DENND3/ARHGAP4/ITSN1/TIMP2/ABCA1/NRP1/PREX1/ARHGAP18/CYTH1/GPR65/ARHGDIB/MYO9B/EPS8/GNA13/AKAP13 19 GO:0032271 regulation of protein polymerization 16/502 232/18722 0.000550760171869707 0.00398892780845714 TMSB4X/NCKAP1L/ICAM1/HSPA1A/PREX1/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 16 GO:0032488 Cdc42 protein signal transduction 4/502 15/18722 0.000550999755642912 0.00398892780845714 APOE/ABCA1/NRP1/WAS 4 GO:0044406 adhesion of symbiont to host 4/502 15/18722 0.000550999755642912 0.00398892780845714 CD209/GAS6/ICAM1/CD81 4 GO:0045346 regulation of MHC class II biosynthetic process 4/502 15/18722 0.000550999755642912 0.00398892780845714 TLR4/SPI1/JAK2/XBP1 4 GO:0051127 positive regulation of actin nucleation 4/502 15/18722 0.000550999755642912 0.00398892780845714 FCHSD2/CYFIP1/WAS/GSN 4 GO:0032728 positive regulation of interferon-beta production 6/502 39/18722 0.0005548172626302 0.00400506386659218 TLR4/TLR7/OAS2/ISG15/OAS1/IFIH1 6 GO:0002548 monocyte chemotaxis 8/502 70/18722 0.000554960211518717 0.00400506386659218 CCL2/CCL3/AIF1/LGMN/CCR1/CCL4/LYN/DUSP1 8 GO:0006027 glycosaminoglycan catabolic process 5/502 26/18722 0.00056054509305499 0.00402051588404646 LYVE1/CD44/TGFB1/GNS/FUCA1 5 GO:1900017 positive regulation of cytokine production involved in inflammatory response 5/502 26/18722 0.00056054509305499 0.00402051588404646 TLR4/CLEC7A/GPSM3/STAT3/HIF1A 5 GO:1905523 positive regulation of macrophage migration 5/502 26/18722 0.00056054509305499 0.00402051588404646 CSF1R/C3AR1/CMKLR1/CCL3/C5AR1 5 GO:0035821 modulation of process of other organism 10/502 106/18722 0.000560577765933845 0.00402051588404646 CD4/MPEG1/CCL3/APOE/IFI27/CCL4/SYK/CLEC7A/ATG7/JUN 10 GO:0007517 muscle organ development 20/502 327/18722 0.000563392021428018 0.00403444503270281 MEF2C/IGF1/RB1/RBPJ/MEF2A/FOS/EGR1/XBP1/BTG2/GPX1/ENG/TCF12/NR4A1/TGFB1/NUPR1/DDX17/DDX5/ZFHX3/CD164/CITED2 20 GO:0043542 endothelial cell migration 18/502 279/18722 0.000564683089838414 0.00403744045377512 MEF2C/SPRED1/LGMN/TMSB4X/APOE/PLXND1/RIN2/GRN/NRP1/GLUL/GPX1/KLF4/NR4A1/TGFB1/HIF1A/SP100/PRCP/RHOB 18 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/502 54/18722 0.000568737417210761 0.00406015322842126 CR1/FCGR2B/NCKAP1L/PTPRC/HAVCR2/PTPN6/AHR 7 GO:0030100 regulation of endocytosis 15/502 211/18722 0.000593811978912962 0.00423262590824555 CD14/APOE/DAB2/CD36/NCKAP1L/BMP2K/B2M/ITSN1/SYK/ARRB2/EHD4/CD63/SDCBP/PPT1/LRP1 15 GO:0046578 regulation of Ras protein signal transduction 14/502 189/18722 0.000597021102092339 0.00424895325889102 LPAR6/IGF1/CYTH4/APOE/DENND3/TIMP2/ABCA1/NRP1/CYTH1/GPR65/ARHGDIB/MYO9B/EPS8/AKAP13 14 GO:0002228 natural killer cell mediated immunity 8/502 71/18722 0.000611022692719523 0.00434192162291937 HLA-B/LGALS9/HLA-A/HAVCR2/ARRB2/HLA-E/LAMP1/PTPN6 8 GO:0042593 glucose homeostasis 17/502 258/18722 0.000628800988729918 0.00446140088016043 GAS6/ICAM1/CYBA/HLA-DRB1/ALOX5/PDK4/OAS1/XBP1/PYGL/UCP2/FOXO3/LGALS1/STAT3/HIF1A/PRCP/LRP1/PIK3R1 17 GO:1900407 regulation of cellular response to oxidative stress 9/502 89/18722 0.000633297461454273 0.00448642275143563 CD36/TLR4/ALOX5/SOD2/ATG7/GPX1/FOXO3/MCL1/HIF1A 9 GO:0038066 p38MAPK cascade 7/502 55/18722 0.000636857513258758 0.00449786695623667 LGALS9/ZFP36L1/SPI1/ZFP36/DUSP1/GADD45B/NCF1 7 GO:1905517 macrophage migration 7/502 55/18722 0.000636857513258758 0.00449786695623667 CSF1R/CCL2/C3AR1/CMKLR1/CCL3/C5AR1/CD81 7 GO:1903532 positive regulation of secretion by cell 18/502 282/18722 0.000639953107559817 0.00451284005422517 SPP1/IGF1/ITGB2/TLR4/ITGAM/HLA-DRB1/ITSN1/SYK/ADAM9/JAK2/GLUL/SDCBP/LAMP1/TGFB1/HIF1A/LRP1/ATP6AP1/RAB8B 18 GO:0010959 regulation of metal ion transport 23/502 406/18722 0.000653909096305531 0.00460423665069922 CCL2/CD4/ATP1B1/CCL3/CD84/CCR1/ICAM1/CYBA/B2M/CCL4/VMP1/ARRB2/PRNP/SLC8A1/LYN/CD63/TSPO/FXYD5/PTPN6/GNAI2/TMBIM6/CAB39/CALM2 23 GO:0033500 carbohydrate homeostasis 17/502 259/18722 0.000656729515758385 0.00461706799376639 GAS6/ICAM1/CYBA/HLA-DRB1/ALOX5/PDK4/OAS1/XBP1/PYGL/UCP2/FOXO3/LGALS1/STAT3/HIF1A/PRCP/LRP1/PIK3R1 17 GO:0033627 cell adhesion mediated by integrin 8/502 72/18722 0.000671569697113202 0.00470943021933237 NCKAP1L/ITGB2/ICAM1/SYK/ADAM9/LYN/FERMT3/PTPN6 8 GO:0031954 positive regulation of protein autophosphorylation 5/502 27/18722 0.000672921179199892 0.00470943021933237 PDGFC/GPNMB/RAP2B/IQGAP1/CALM2 5 GO:0032967 positive regulation of collagen biosynthetic process 5/502 27/18722 0.000672921179199892 0.00470943021933237 RUNX1/ARRB2/VIM/ENG/TGFB1 5 GO:0034109 homotypic cell-cell adhesion 9/502 90/18722 0.00068729791597066 0.00479553568518895 PLEK/SYK/LYN/ACTB/RAP2B/FERMT3/JAK2/LGALS1/PTPN6 9 GO:0061097 regulation of protein tyrosine kinase activity 9/502 90/18722 0.00068729791597066 0.00479553568518895 CSF1R/GAS6/FCGR1A/PTPRC/PRNP/RAP2B/SNX6/NCF1/ABI1 9 GO:0001503 ossification 23/502 408/18722 0.000699108308097786 0.00487059492960897 SPP1/MEF2C/IGF1/RUNX1/CCL3/GPNMB/CCR1/BMP2K/SRGN/RBPJ/PTGER4/ALOX5/SLC8A1/ISG15/CLTC/JUNB/TGFB1/DHRS3/HIF1A/DDX5/DNAJC13/ATP6AP1/ADAR 23 GO:0046456 icosanoid biosynthetic process 7/502 56/18722 0.000711291291077011 0.00494802031958233 HPGDS/CD74/ALOX5AP/TBXAS1/SYK/ALOX5/MGST2 7 GO:0002830 positive regulation of type 2 immune response 4/502 16/18722 0.000719181518544981 0.00498043967782797 CD74/CD86/RSAD2/CD81 4 GO:0034138 toll-like receptor 3 signaling pathway 4/502 16/18722 0.000719181518544981 0.00498043967782797 UNC93B1/HAVCR2/OAS1/COLEC12 4 GO:0045342 MHC class II biosynthetic process 4/502 16/18722 0.000719181518544981 0.00498043967782797 TLR4/SPI1/JAK2/XBP1 4 GO:0032735 positive regulation of interleukin-12 production 6/502 41/18722 0.000730819366432372 0.00504592595390471 CD36/LAPTM5/TLR4/LGALS9/SYK/CLEC7A 6 GO:1905521 regulation of macrophage migration 6/502 41/18722 0.000730819366432372 0.00504592595390471 CSF1R/C3AR1/CMKLR1/CCL3/C5AR1/CD81 6 GO:0014706 striated muscle tissue development 22/502 384/18722 0.000733642690604719 0.0050578704720379 MEF2C/IGF1/RUNX1/RB1/RBPJ/ARRB2/MEF2A/SLC8A1/FOS/EGR1/BTG2/TGFBR2/GPX1/ENG/NR4A1/TGFB1/NUPR1/DDX17/DDX5/CITED2/PRKAR1A/AKAP13 22 GO:0071456 cellular response to hypoxia 12/502 151/18722 0.000780197275878389 0.00536284189927701 CYBB/ICAM1/ZFP36L1/RBPJ/MALAT1/SLC8A1/EGR1/FOXO3/HIF1A/TMBIM6/BNIP3L/CITED2 12 GO:2001236 regulation of extrinsic apoptotic signaling pathway 12/502 151/18722 0.000780197275878389 0.00536284189927701 IGF1/ICAM1/PTPRC/HSPA1A/NRP1/PYCARD/GPX1/MCL1/SP100/FEM1B/SKIL/STK4 12 GO:0033619 membrane protein proteolysis 7/502 57/18722 0.000792446360076459 0.00543544074130665 APOE/TNFRSF1B/TIMP2/ADAM9/TGFB1/TIMP1/ADAM10 7 GO:0002313 mature B cell differentiation involved in immune response 5/502 28/18722 0.000801333892254893 0.00543544074130665 CR1/FCGR2B/SPI1/XBP1/LGALS1 5 GO:0010714 positive regulation of collagen metabolic process 5/502 28/18722 0.000801333892254893 0.00543544074130665 RUNX1/ARRB2/VIM/ENG/TGFB1 5 GO:0032607 interferon-alpha production 5/502 28/18722 0.000801333892254893 0.00543544074130665 TLR4/TLR7/HAVCR2/IFIH1/STAT1 5 GO:0032647 regulation of interferon-alpha production 5/502 28/18722 0.000801333892254893 0.00543544074130665 TLR4/TLR7/HAVCR2/IFIH1/STAT1 5 GO:0032801 receptor catabolic process 5/502 28/18722 0.000801333892254893 0.00543544074130665 LGMN/APOE/LAPTM5/DTX3L/TGFB1 5 GO:0038094 Fc-gamma receptor signaling pathway 5/502 28/18722 0.000801333892254893 0.00543544074130665 FCER1G/FCGR2B/PTPRC/SYK/LYN 5 GO:0045589 regulation of regulatory T cell differentiation 5/502 28/18722 0.000801333892254893 0.00543544074130665 CD28/CR1/LGALS9/HLA-DRA/HLA-DRB1 5 GO:0061082 myeloid leukocyte cytokine production 5/502 28/18722 0.000801333892254893 0.00543544074130665 CD74/CD36/LAPTM5/TLR4/TGFB1 5 GO:0051452 intracellular pH reduction 6/502 42/18722 0.000833578024031379 0.00563761979410696 GRN/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1 6 GO:0051602 response to electrical stimulus 6/502 42/18722 0.000833578024031379 0.00563761979410696 CD14/AIF1/SOD2/BTG2/CYFIP1/NR4A1 6 GO:0030522 intracellular receptor signaling pathway 17/502 265/18722 0.000847653894621256 0.00572444805331085 DAB2/TLR4/NR4A2/KLF2/HSPA1A/SLC15A3/JAK2/NR4A1/IFIH1/DHRS3/NCOA4/STAT3/DDX17/DDX5/AHR/PRCP/CITED2 17 GO:1901222 regulation of NIK/NF-kappaB signaling 10/502 112/18722 0.000863860659141325 0.00582539272476351 CD14/TMSB4X/LAPTM5/TLR4/TLR7/LGALS9/CD86/HAVCR2/SPI1/LITAF 10 GO:0060249 anatomical structure homeostasis 19/502 314/18722 0.000871977371158785 0.00585638906113067 SPP1/CSF1R/TLR4/ALDH1A1/TPP1/B2M/RB1/SYK/PECAM1/ACTB/PDK4/OAS1/LIPA/ACP5/HIF1A/DRAM2/GAA/ATP6AP1/TAOK1 19 GO:0045185 maintenance of protein location 9/502 93/18722 0.000872255093627115 0.00585638906113067 CD4/TMSB4X/SRGN/CCDC88A/VPS13C/TSPO/SP100/CHCHD10/GSN 9 GO:0051591 response to cAMP 9/502 93/18722 0.000872255093627115 0.00585638906113067 ZFP36L1/ITPR2/SLC8A1/FOS/DUSP1/FOSB/STAT1/AHR/JUN 9 GO:0051453 regulation of intracellular pH 8/502 75/18722 0.000882754434923239 0.00591829277674624 SLC9A9/GRN/DMXL2/ATP6V0A1/PPT1/ATP6AP2/DMXL1/SLC4A7 8 GO:0010952 positive regulation of peptidase activity 14/502 197/18722 0.000897120110499039 0.00600590105813105 CR1/LGMN/LAPTM5/IFI16/LGALS9/SYK/GRN/CTSD/LYN/CLEC7A/JAK2/PYCARD/STAT3/GSN 14 GO:1905475 regulation of protein localization to membrane 13/502 175/18722 0.000901656317965051 0.00602754642616521 DAB2/ITGB2/ITGAM/PRNP/CD81/ACTB/CLTC/STX7/TGFB1/LRP1/PIK3R1/GSN/ADAM10 13 GO:0044706 multi-multicellular organism process 15/502 220/18722 0.000912153249577649 0.00608891909458327 SPP1/CTSB/LGALS9/VMP1/HAVCR2/FOS/JUNB/NAMPT/TGFBR2/UCP2/FOSB/ARHGDIB/TIMP1/ADCY7/CITED2 15 GO:0016045 detection of bacterium 4/502 17/18722 0.000920663793350822 0.00611923952304727 NAIP/HLA-B/HLA-A/HLA-DRB1 4 GO:0042953 lipoprotein transport 4/502 17/18722 0.000920663793350822 0.00611923952304727 CD36/MSR1/VMP1/LRP1 4 GO:0045591 positive regulation of regulatory T cell differentiation 4/502 17/18722 0.000920663793350822 0.00611923952304727 CR1/LGALS9/HLA-DRA/HLA-DRB1 4 GO:0019080 viral gene expression 9/502 94/18722 0.00094220281894206 0.00624157934042721 CCL3/CCL4/MGAT4A/IFITM3/ZFP36/PARP9/MGAT1/USF2/JUN 9 GO:0006509 membrane protein ectodomain proteolysis 6/502 43/18722 0.000947125775710835 0.00624157934042721 APOE/TNFRSF1B/TIMP2/ADAM9/TIMP1/ADAM10 6 GO:0014002 astrocyte development 6/502 43/18722 0.000947125775710835 0.00624157934042721 C1QA/TLR4/C5AR1/GRN/VIM/LRP1 6 GO:0001773 myeloid dendritic cell activation 5/502 29/18722 0.000947165736485063 0.00624157934042721 RBPJ/HAVCR2/SPI1/PYCARD/TGFBR2 5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 5/502 29/18722 0.000947165736485063 0.00624157934042721 FCGR2B/HLA-DRB1/SYK/LYN/GPX1 5 GO:0090025 regulation of monocyte chemotaxis 5/502 29/18722 0.000947165736485063 0.00624157934042721 AIF1/LGMN/CCR1/LYN/DUSP1 5 GO:0014855 striated muscle cell proliferation 8/502 76/18722 0.000963918079935186 0.00634293746483666 MEF2C/RUNX1/RBPJ/JAK2/TGFBR2/STAT3/CITED2/PRKAR1A 8 GO:0007519 skeletal muscle tissue development 12/502 155/18722 0.000981629176165225 0.0064503076263357 MEF2C/RB1/FOS/EGR1/BTG2/GPX1/NR4A1/TGFB1/NUPR1/DDX17/DDX5/CITED2 12 GO:0009267 cellular response to starvation 12/502 156/18722 0.00103823681975841 0.00680427661638684 GAS6/IFI16/PDK4/CPEB4/XBP1/ATG7/GLUL/UCP2/FOXO3/LAMP2/SESN1/JUN 12 GO:0071902 positive regulation of protein serine/threonine kinase activity 14/502 200/18722 0.0010384391031494 0.00680427661638684 CSF1R/PDGFC/TLR4/SYK/ADAM9/IQGAP1/TGFB1/DAZAP2/TAOK3/CAB39/CALM2/TAOK1/STK4/AKAP13 14 GO:0002712 regulation of B cell mediated immunity 7/502 60/18722 0.00108051333141895 0.00705996422477974 CD28/CR1/FCGR2B/PTPRC/HLA-E/TGFB1/PTPN6 7 GO:0002889 regulation of immunoglobulin mediated immune response 7/502 60/18722 0.00108051333141895 0.00705996422477974 CD28/CR1/FCGR2B/PTPRC/HLA-E/TGFB1/PTPN6 7 GO:0007034 vacuolar transport 12/502 157/18722 0.00109753149019123 0.00714786741833472 LAPTM5/DENND3/PSAP/GRN/HSPA1A/VPS13C/DTX3L/LAMP1/LAMP2/NCOA4/LRP1/RHOB 12 GO:0051017 actin filament bundle assembly 12/502 157/18722 0.00109753149019123 0.00714786741833472 MARCKS/AIF1/PLEK/MTSS1/CCDC88A/PTGER4/LCP1/NRP1/GPR65/WAS/EPS8/PIK3R1 12 GO:0006816 calcium ion transport 23/502 422/18722 0.00109860219075572 0.00714786741833472 CCL2/CD4/ATP1B1/GAS6/CCL3/CD84/CCR1/ICAM1/CYBA/PTPRC/CCL4/VMP1/MCOLN1/ITPR2/ARRB2/PRNP/SLC8A1/LYN/TSPO/PTPN6/GNAI2/TMBIM6/CALM2 23 GO:1903305 regulation of regulated secretory pathway 11/502 136/18722 0.00110502257625293 0.00717954274964335 CD84/FCGR2B/NCKAP1L/ITGB2/LGALS9/ITGAM/SPI1/SYK/LYN/LAMP1/GNAI2 11 GO:0010950 positive regulation of endopeptidase activity 13/502 179/18722 0.00111001256171518 0.00719348178669554 CR1/LGMN/LAPTM5/IFI16/LGALS9/SYK/CTSD/LYN/CLEC7A/JAK2/PYCARD/STAT3/GSN 13 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 5/502 30/18722 0.00111183300421256 0.00719348178669554 FCGR2B/LAPTM5/PRNP/PTPN6/DUSP3 5 GO:0051125 regulation of actin nucleation 5/502 30/18722 0.00111183300421256 0.00719348178669554 FCHSD2/GMFG/CYFIP1/WAS/GSN 5 GO:0050890 cognition 18/502 296/18722 0.00111620517485614 0.00720162501936471 MEF2C/GATM/LGMN/APOE/HLA-DRA/B2M/GPR155/C5AR1/PRNP/FOS/SLC11A2/BTG2/ACTR2/SGK1/CYFIP1/PPT1/HIF1A/JUN 18 GO:0051258 protein polymerization 18/502 296/18722 0.00111620517485614 0.00720162501936471 AIF1/TMSB4X/NCKAP1L/ICAM1/HSPA1A/PREX1/JAK2/FCHSD2/PYCARD/ARHGAP18/ACTR2/GMFG/CYFIP1/WAS/CAPG/CAPZA2/EPS8/GSN 18 GO:0017157 regulation of exocytosis 14/502 202/18722 0.00114268592401971 0.00735111822171336 CD84/FCGR2B/NCKAP1L/ITGB2/LGALS9/ITGAM/SPI1/SYK/LYN/SDCBP/LAMP1/GNAI2/ATP6AP1/RAB8B 14 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 8/502 78/18722 0.00114414291388535 0.00735111822171336 GAS6/NAIP/ARRB2/GPX1/CD44/KLF4/NR4A1/HERPUD1 8 GO:0070373 negative regulation of ERK1 and ERK2 cascade 8/502 78/18722 0.00114414291388535 0.00735111822171336 SPRED1/TLR4/PTPRC/LYN/SIRPA/DUSP1/KLF4/DUSP3 8 GO:0002223 stimulatory C-type lectin receptor signaling pathway 4/502 18/18722 0.00115880711719711 0.00736351885185967 TYROBP/SYK/LYN/CLEC7A 4 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 4/502 18/18722 0.00115880711719711 0.00736351885185967 CR1/FCGR2B/PTPRC/PTPN6 4 GO:0030889 negative regulation of B cell proliferation 4/502 18/18722 0.00115880711719711 0.00736351885185967 TYROBP/FCGR2B/LYN/ATM 4 GO:0044872 lipoprotein localization 4/502 18/18722 0.00115880711719711 0.00736351885185967 CD36/MSR1/VMP1/LRP1 4 GO:0097709 connective tissue replacement 4/502 18/18722 0.00115880711719711 0.00736351885185967 RUNX1/TGFB1/TIMP1/HIF1A 4 GO:0150079 negative regulation of neuroinflammatory response 4/502 18/18722 0.00115880711719711 0.00736351885185967 IGF1/PTPRC/TNFRSF1B/GRN 4 GO:1990840 response to lectin 4/502 18/18722 0.00115880711719711 0.00736351885185967 TYROBP/SYK/LYN/CLEC7A 4 GO:1990858 cellular response to lectin 4/502 18/18722 0.00115880711719711 0.00736351885185967 TYROBP/SYK/LYN/CLEC7A 4 GO:0010977 negative regulation of neuron projection development 11/502 137/18722 0.0011731948837941 0.0074345199074404 SPP1/PMP22/APOE/CTSZ/B2M/ARHGAP4/NRP1/VIM/LGALS1/RTN4/LRP1 11 GO:0045471 response to ethanol 11/502 137/18722 0.0011731948837941 0.0074345199074404 CD14/CYBB/ICAM1/ITPR2/TBXAS1/SPI1/SOD2/ACTR2/STAT3/ADCY7/EPS8 11 GO:0051495 positive regulation of cytoskeleton organization 15/502 226/18722 0.00119640005597633 0.00757119925984471 PLEK/NCKAP1L/ICAM1/MTSS1/CCDC88A/HSPA1A/NRP1/FCHSD2/PYCARD/ACTR2/GPR65/GMFG/CYFIP1/WAS/GSN 15 GO:0010720 positive regulation of cell development 18/502 298/18722 0.00120424843904526 0.00761045529921227 TYROBP/PLXND1/TNFRSF1B/NRP1/LYN/CLEC7A/PREX1/ACTR2/TSPO/CYFIP1/TGFB1/HIF1A/LRP1/MACF1/GOLGA4/ATP6AP1/SKIL/PLXNB2 18 GO:0071364 cellular response to epidermal growth factor stimulus 6/502 45/18722 0.00120956670874099 0.00762323650495341 ZFP36L1/ZFP36/IQGAP1/ZFP36L2/SNX6/DUSP3 6 GO:2000273 positive regulation of signaling receptor activity 6/502 45/18722 0.00120956670874099 0.00762323650495341 CCL2/NRP1/JAK2/IFNGR2/NCF1/HIF1A 6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 8/502 79/18722 0.00124381406880116 0.00780765744132207 IGF1/CD28/PDGFC/PIK3AP1/HCST/JAK2/NCF1/PTPN6 8 GO:0050772 positive regulation of axonogenesis 8/502 79/18722 0.00124381406880116 0.00780765744132207 PLXND1/NRP1/CYFIP1/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 8 GO:0050808 synapse organization 23/502 426/18722 0.00124389181458158 0.00780765744132207 C1QA/C1QB/C1QC/MEF2C/FCGR2B/LGMN/APOE/PLXND1/SRGN/ITGAM/ITSN1/IL10RA/C5AR1/PRNP/TUBA1A/NRP1/ACTB/SDCBP/ACTR2/CYFIP1/CHCHD10/ADAM10/PLXNB2 23 GO:0051101 regulation of DNA binding 10/502 118/18722 0.0012905270255068 0.00808410223725362 IGF1/TMSB4X/IFI16/RB1/JAK2/KLF4/TGFB1/SP100/JUN/CALM2 10 GO:0048017 inositol lipid-mediated signaling 13/502 182/18722 0.00129142921602474 0.00808410223725362 CSF1R/IGF1/CD28/ADAP2/PDGFC/ZFP36L1/PIK3AP1/HCST/JAK2/KLF4/NCF1/PTPN6/PIK3R1 13 GO:0030149 sphingolipid catabolic process 5/502 31/18722 0.0012967817854457 0.00809569843383509 ENPP2/ASAH1/PPT1/ACER3/HEXA 5 GO:0045066 regulatory T cell differentiation 5/502 31/18722 0.0012967817854457 0.00809569843383509 CD28/CR1/LGALS9/HLA-DRA/HLA-DRB1 5 GO:0060135 maternal process involved in female pregnancy 7/502 62/18722 0.00131422329772094 0.00819352692083166 SPP1/CTSB/LGALS9/HAVCR2/JUNB/ADCY7/CITED2 7 GO:0045861 negative regulation of proteolysis 20/502 351/18722 0.00134257174602387 0.00835899986151605 A2M/GAS6/CR1/NAIP/BST2/CTSZ/IFI16/TIMP2/CST3/SERPING1/ARRB2/PRNP/SDCBP/GPX1/CD44/KLF4/NR4A1/TIMP1/LRP1/HERPUD1 20 GO:0016049 cell growth 25/502 482/18722 0.00136192229350307 0.00845555329850514 SPP1/IGF1/IGFBP4/APOE/BST2/CYBA/ARHGAP4/RB1/CXCL16/HSPA1A/NRP1/ITSN2/IQGAP1/TGFBR2/SDCBP/SGK1/CYFIP1/PPT1/TGFB1/RTN4/LRP1/MACF1/GOLGA4/ADAM10/AKAP13 25 GO:0030838 positive regulation of actin filament polymerization 9/502 99/18722 0.00136346996212728 0.00845555329850514 NCKAP1L/ICAM1/FCHSD2/PYCARD/ACTR2/GMFG/CYFIP1/WAS/GSN 9 GO:0061572 actin filament bundle organization 12/502 161/18722 0.00136356306975461 0.00845555329850514 MARCKS/AIF1/PLEK/MTSS1/CCDC88A/PTGER4/LCP1/NRP1/GPR65/WAS/EPS8/PIK3R1 12 GO:0060537 muscle tissue development 22/502 403/18722 0.00136920222384552 0.00847915594044091 MEF2C/IGF1/RUNX1/RB1/RBPJ/ARRB2/MEF2A/SLC8A1/FOS/EGR1/BTG2/TGFBR2/GPX1/ENG/NR4A1/TGFB1/NUPR1/DDX17/DDX5/CITED2/PRKAR1A/AKAP13 22 GO:0002281 macrophage activation involved in immune response 4/502 19/18722 0.00143697033494384 0.0087979628620816 TYROBP/HAVCR2/SYK/GRN 4 GO:0007039 protein catabolic process in the vacuole 4/502 19/18722 0.00143697033494384 0.0087979628620816 TPP1/CD81/LAMP2/LRP1 4 GO:0010759 positive regulation of macrophage chemotaxis 4/502 19/18722 0.00143697033494384 0.0087979628620816 CSF1R/C3AR1/CMKLR1/C5AR1 4 GO:0033194 response to hydroperoxide 4/502 19/18722 0.00143697033494384 0.0087979628620816 AIF1/CD36/JAK2/GPX1 4 GO:0043031 negative regulation of macrophage activation 4/502 19/18722 0.00143697033494384 0.0087979628620816 VSIG4/FCGR2B/PTPRC/GRN 4 GO:0046794 transport of virus 4/502 19/18722 0.00143697033494384 0.0087979628620816 SIGLEC1/CD209/BST2/EPS15 4 GO:1903978 regulation of microglial cell activation 4/502 19/18722 0.00143697033494384 0.0087979628620816 CCL3/CTSC/PTPRC/GRN 4 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 4/502 19/18722 0.00143697033494384 0.0087979628620816 RUNX1/NCKAP1L/HLA-A/HLA-E 4 GO:0051100 negative regulation of binding 12/502 162/18722 0.00143779937823902 0.0087979628620816 TMSB4X/DAB2/CTSZ/IFI16/B2M/IFIT1/ARRB2/ACTB/JAK2/TMBIM6/SP100/JUN 12 GO:0051346 negative regulation of hydrolase activity 21/502 379/18722 0.00145450908063879 0.00888845311365263 A2M/GAS6/CR1/NAIP/NCKAP1L/BST2/IFI16/TIMP2/CST3/SERPING1/ARRB2/PRNP/GPX1/CD44/KLF4/NR4A1/TIMP1/GNAI2/TMBIM6/LRP1/HERPUD1 21 GO:0001960 negative regulation of cytokine-mediated signaling pathway 8/502 81/18722 0.00146385828733867 0.00893378421797981 GAS6/PTPRC/SAMHD1/PARP14/ISG15/OAS1/STAT2/ADAR 8 GO:0043433 negative regulation of DNA-binding transcription factor activity 13/502 185/18722 0.00149688055283608 0.00912327989119858 GAS6/TMIGD3/CMKLR1/TMSB4X/RB1/HAVCR2/SPI1/ARRB2/PRNP/PYCARD/KLF4/NUPR1/SP100 13 GO:0006026 aminoglycan catabolic process 5/502 32/18722 0.00150348396514087 0.00915146950360748 LYVE1/CD44/TGFB1/GNS/FUCA1 5 GO:0010712 regulation of collagen metabolic process 6/502 47/18722 0.001524291926423 0.00925377224623726 RUNX1/CST3/ARRB2/VIM/ENG/TGFB1 6 GO:0014911 positive regulation of smooth muscle cell migration 6/502 47/18722 0.001524291926423 0.00925377224623726 IGF1/AIF1/TLR4/NRP1/IQGAP1/LRP1 6 GO:0010594 regulation of endothelial cell migration 15/502 232/18722 0.00155181766256054 0.00940853015334869 MEF2C/SPRED1/LGMN/TMSB4X/APOE/RIN2/GRN/NRP1/GLUL/KLF4/TGFB1/HIF1A/SP100/PRCP/RHOB 15 GO:0048638 regulation of developmental growth 19/502 330/18722 0.00155698251029334 0.00942533208988254 SPP1/MEF2C/IGF1/RUNX1/LGMN/APOE/ARHGAP4/RBPJ/NRP1/ITSN2/TGFBR2/CYFIP1/STAT3/RTN4/LRP1/MACF1/GOLGA4/CITED2/STK4 19 GO:0002455 humoral immune response mediated by circulating immunoglobulin 10/502 121/18722 0.00156070133611112 0.00942533208988254 C1QA/C1QB/C1QC/C2/CR1/FCGR2B/PTPRC/SERPING1/CD81/PTPN6 10 GO:0043500 muscle adaptation 10/502 121/18722 0.00156070133611112 0.00942533208988254 IGF1/GATM/AIF1/CYBA/TNFRSF1B/MEF2A/FOXO3/TNFRSF1A/KLF4/GSN 10 GO:1905897 regulation of response to endoplasmic reticulum stress 8/502 82/18722 0.0015848883650802 0.0095589225252425 FCGR2B/ALOX5/HSPA1A/XBP1/NUPR1/TMBIM6/PIK3R1/HERPUD1 8 GO:0038061 NIK/NF-kappaB signaling 11/502 143/18722 0.00165877423826415 0.00999152295079423 CD14/TMSB4X/LAPTM5/TLR4/TLR7/LGALS9/CD86/HAVCR2/SPI1/REL/LITAF 11 GO:0033628 regulation of cell adhesion mediated by integrin 6/502 48/18722 0.00170326173455231 0.0102461492640299 NCKAP1L/SYK/ADAM9/LYN/FERMT3/PTPN6 6 GO:0043491 protein kinase B signaling 14/502 211/18722 0.001726879865383 0.0103747353990413 CCL2/IGF1/GAS6/CD28/CCL3/ZFP36L1/ARRB2/MTDH/GPX1/ENG/KLF4/TGFB1/SETX/RTN4 14 GO:0001975 response to amphetamine 5/502 33/18722 0.00173343322786008 0.0103805587294123 ICAM1/NR4A2/RGS10/NR4A1/RANBP2 5 GO:0002335 mature B cell differentiation 5/502 33/18722 0.00173343322786008 0.0103805587294123 CR1/FCGR2B/SPI1/XBP1/LGALS1 5 GO:0003170 heart valve development 7/502 65/18722 0.00173682500141918 0.0103805587294123 MEF2C/TNFRSF1B/RB1/RBPJ/TGFBR2/TNFRSF1A/TGFB1 7 GO:0045453 bone resorption 7/502 65/18722 0.00173682500141918 0.0103805587294123 SPP1/CSF1R/TPP1/SYK/PDK4/ACP5/ATP6AP1 7 GO:0010324 membrane invagination 11/502 144/18722 0.00175373434229991 0.0104143454011289 AIF1/FCGR2B/CD36/MSR1/NCKAP1L/ITGB2/FCGR1A/ITGAM/ABCA1/FCHO2/GSN 11 GO:0010821 regulation of mitochondrion organization 11/502 144/18722 0.00175373434229991 0.0104143454011289 IGF1/ARRB2/HSPA1A/VPS13C/PYCARD/GPX1/TSPO/HIF1A/STAT2/CHCHD10/BNIP3L 11 GO:0014065 phosphatidylinositol 3-kinase signaling 11/502 144/18722 0.00175373434229991 0.0104143454011289 IGF1/CD28/PDGFC/ZFP36L1/PIK3AP1/HCST/JAK2/KLF4/NCF1/PTPN6/PIK3R1 11 GO:0106106 cold-induced thermogenesis 11/502 144/18722 0.00175373434229991 0.0104143454011289 GATM/CMKLR1/PDGFC/CD36/TLR4/ALDH1A1/RB1/RBPJ/SYK/JAK2/UCP2 11 GO:0120161 regulation of cold-induced thermogenesis 11/502 144/18722 0.00175373434229991 0.0104143454011289 GATM/CMKLR1/PDGFC/CD36/TLR4/ALDH1A1/RB1/RBPJ/SYK/JAK2/UCP2 11 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/502 20/18722 0.00175849384120788 0.0104292211659329 HSPA1A/XBP1/TMBIM6/HERPUD1 4 GO:0045786 negative regulation of cell cycle 21/502 385/18722 0.00176133602851137 0.0104327022636281 CCL2/GPNMB/ZFP36L1/RB1/TIMP2/ATM/BTG2/DUSP1/ZFP36L2/KLF4/NR4A1/NABP1/TGFB1/PRKACB/NUPR1/TAOK3/FEM1B/ATF5/RHOB/TAOK1/PRKAR1A 21 GO:0060538 skeletal muscle organ development 12/502 166/18722 0.00176891705022495 0.0104642075119445 MEF2C/RB1/FOS/EGR1/BTG2/GPX1/NR4A1/TGFB1/NUPR1/DDX17/DDX5/CITED2 12 GO:0006469 negative regulation of protein kinase activity 14/502 212/18722 0.00180488370455532 0.0106633359096716 SPRED1/APOE/PTPRC/RB1/SLC8A1/LYN/PYCARD/DUSP1/SNX6/GADD45B/PTPN6/DUSP3/ADAR/PRKAR1A 14 GO:0048762 mesenchymal cell differentiation 15/502 236/18722 0.00183479643958942 0.01082623511421 MEF2C/SPRED1/DAB2/RBPJ/NRP1/TGFBR2/SDCBP/ENG/TGFB1/STAT1/HIF1A/DDX17/DDX5/RTN4/CITED2 15 GO:0007254 JNK cascade 12/502 167/18722 0.00186081060229171 0.0109657450270082 FCGR2B/TLR4/TLR7/PTGER4/SIRPA/PYCARD/SDCBP/GADD45B/NCF1/DUSP3/TAOK3/TAOK1 12 GO:0002762 negative regulation of myeloid leukocyte differentiation 6/502 49/18722 0.00189773562346188 0.0111194514180447 C1QC/CCL3/MAFB/TLR4/LYN/PIK3R1 6 GO:0014075 response to amine 6/502 49/18722 0.00189773562346188 0.0111194514180447 ICAM1/NR4A2/HNMT/RGS10/NR4A1/RANBP2 6 GO:0070849 response to epidermal growth factor 6/502 49/18722 0.00189773562346188 0.0111194514180447 ZFP36L1/ZFP36/IQGAP1/ZFP36L2/SNX6/DUSP3 6 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/502 49/18722 0.00189773562346188 0.0111194514180447 ICAM1/GPX1/SP100/FEM1B/SKIL/STK4 6 GO:0045600 positive regulation of fat cell differentiation 7/502 66/18722 0.0018989119369337 0.0111194514180447 CMKLR1/METRNL/ZFP36L1/ZFP36/XBP1/CREBL2/STK4 7 GO:0001558 regulation of cell growth 22/502 414/18722 0.00191904867497399 0.0112231595074964 SPP1/IGF1/IGFBP4/APOE/BST2/CYBA/ARHGAP4/RB1/CXCL16/HSPA1A/NRP1/ITSN2/SDCBP/SGK1/CYFIP1/PPT1/TGFB1/RTN4/LRP1/MACF1/GOLGA4/ADAM10 22 GO:0002446 neutrophil mediated immunity 5/502 34/18722 0.00198814108769982 0.0114664067955513 ITGB2/ITGAM/SPI1/SYK/KMT2E 5 GO:0010922 positive regulation of phosphatase activity 5/502 34/18722 0.00198814108769982 0.0114664067955513 MEF2C/PLEK/PTPRC/JAK2/CALM2 5 GO:0030851 granulocyte differentiation 5/502 34/18722 0.00198814108769982 0.0114664067955513 C1QC/RUNX1/SPI1/EVI2B/CITED2 5 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 5/502 34/18722 0.00198814108769982 0.0114664067955513 SPRED1/CD74/ATM/CD44/DDX5 5 GO:0001915 negative regulation of T cell mediated cytotoxicity 3/502 10/18722 0.00199782184980855 0.0114664067955513 FCGR2B/NCKAP1L/PTPRC 3 GO:0035747 natural killer cell chemotaxis 3/502 10/18722 0.00199782184980855 0.0114664067955513 CCL2/CCL3/CCL4 3 GO:0045348 positive regulation of MHC class II biosynthetic process 3/502 10/18722 0.00199782184980855 0.0114664067955513 TLR4/JAK2/XBP1 3 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 3/502 10/18722 0.00199782184980855 0.0114664067955513 PTPRC/LYN/PLSCR1 3 GO:0070391 response to lipoteichoic acid 3/502 10/18722 0.00199782184980855 0.0114664067955513 CD14/CD36/TLR4 3 GO:0071223 cellular response to lipoteichoic acid 3/502 10/18722 0.00199782184980855 0.0114664067955513 CD14/CD36/TLR4 3 GO:0090647 modulation of age-related behavioral decline 3/502 10/18722 0.00199782184980855 0.0114664067955513 B2M/PRNP/BAZ2B 3 GO:1902946 protein localization to early endosome 3/502 10/18722 0.00199782184980855 0.0114664067955513 NRP1/DTX3L/MSN 3 GO:2000510 positive regulation of dendritic cell chemotaxis 3/502 10/18722 0.00199782184980855 0.0114664067955513 GAS6/LGALS9/SPI1 3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 3/502 10/18722 0.00199782184980855 0.0114664067955513 FCHSD2/CYFIP1/WAS 3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/502 10/18722 0.00199782184980855 0.0114664067955513 LGALS9/JAK2/GSN 3 GO:1903531 negative regulation of secretion by cell 11/502 147/18722 0.00206555207025022 0.0118404509008396 CD84/FCGR2B/APOE/NCKAP1L/LGALS9/TNFRSF1B/RSAD2/SPI1/UCP2/TNFRSF1A/GNAI2 11 GO:0032872 regulation of stress-activated MAPK cascade 13/502 192/18722 0.00208339596333318 0.0119279575821526 FCGR2B/TLR4/SPI1/CLEC7A/SIRPA/PYCARD/DUSP1/SDCBP/GADD45B/NCF1/DUSP3/TAOK3/TAOK1 13 GO:0002639 positive regulation of immunoglobulin production 6/502 50/18722 0.00210855611057351 0.0120122609994526 CD28/PTPRC/CD86/HLA-E/XBP1/TGFB1 6 GO:0019083 viral transcription 6/502 50/18722 0.00210855611057351 0.0120122609994526 CCL3/CCL4/IFITM3/ZFP36/USF2/JUN 6 GO:0045058 T cell selection 6/502 50/18722 0.00210855611057351 0.0120122609994526 CD4/CD28/CD74/PTPRC/SYK/STAT3 6 GO:0032874 positive regulation of stress-activated MAPK cascade 10/502 126/18722 0.00211164278078368 0.0120122609994526 FCGR2B/TLR4/SPI1/CLEC7A/PYCARD/SDCBP/GADD45B/NCF1/TAOK3/TAOK1 10 GO:0019370 leukotriene biosynthetic process 4/502 21/18722 0.00212668434037001 0.0120122609994526 ALOX5AP/SYK/ALOX5/MGST2 4 GO:0030449 regulation of complement activation 4/502 21/18722 0.00212668434037001 0.0120122609994526 VSIG4/A2M/CR1/SERPING1 4 GO:0030502 negative regulation of bone mineralization 4/502 21/18722 0.00212668434037001 0.0120122609994526 CCL3/CCR1/SRGN/HIF1A 4 GO:0033630 positive regulation of cell adhesion mediated by integrin 4/502 21/18722 0.00212668434037001 0.0120122609994526 NCKAP1L/SYK/ADAM9/PTPN6 4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 4/502 21/18722 0.00212668434037001 0.0120122609994526 FCHSD2/GMFG/CYFIP1/WAS 4 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 4/502 21/18722 0.00212668434037001 0.0120122609994526 CD74/CD36/LAPTM5/TLR4 4 GO:0071498 cellular response to fluid shear stress 4/502 21/18722 0.00212668434037001 0.0120122609994526 MEF2C/MTSS1/KLF2/KLF4 4 GO:0051384 response to glucocorticoid 11/502 148/18722 0.00217897747463961 0.0122926217044913 AIF1/ICAM1/ZFP36L1/ZFP36/ADAM9/FOS/HNMT/DUSP1/ZFP36L2/FOXO3/FOSB 11 GO:0001824 blastocyst development 9/502 106/18722 0.00219516721150626 0.0123688715230548 LPAR6/IGF1/JUNB/KLF4/N4BP2L2/CMTM3/RTN4/CITED2/SKIL 9 GO:0006911 phagocytosis, engulfment 10/502 127/18722 0.00223864287359941 0.012598493836096 AIF1/FCGR2B/CD36/MSR1/NCKAP1L/ITGB2/FCGR1A/ITGAM/ABCA1/GSN 10 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 7/502 68/18722 0.0022580552679241 0.0126615317205053 LGALS9/HLA-DRA/HLA-DRB1/CD86/PTGER4/STAT3/NFKBIZ 7 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 7/502 68/18722 0.0022580552679241 0.0126615317205053 CSF1R/IGF1/PARP14/LYN/PARP9/JAK2/TNFRSF1A 7 GO:0046686 response to cadmium ion 7/502 68/18722 0.0022580552679241 0.0126615317205053 CYBB/B2M/PRNP/FOS/SOD2/NCF1/JUN 7 GO:0051048 negative regulation of secretion 12/502 171/18722 0.00226843364915324 0.0126775471873464 CD84/FCGR2B/APOE/CD74/NCKAP1L/LGALS9/TNFRSF1B/RSAD2/SPI1/UCP2/TNFRSF1A/GNAI2 12 GO:0001569 branching involved in blood vessel morphogenesis 5/502 35/18722 0.00226913295960285 0.0126775471873464 PLXND1/NRP1/TGFBR2/ENG/STK4 5 GO:0032814 regulation of natural killer cell activation 5/502 35/18722 0.00226913295960285 0.0126775471873464 GAS6/TYROBP/HAVCR2/HLA-E/LAMP1 5 GO:0071622 regulation of granulocyte chemotaxis 6/502 51/18722 0.00233657865018962 0.0130386162072101 CSF1R/C3AR1/CMKLR1/CD74/NCKAP1L/C5AR1 6 GO:0008637 apoptotic mitochondrial changes 9/502 107/18722 0.0023413071244509 0.0130492611538673 IGF1/ARRB2/HSPA1A/SOD2/PYCARD/GPX1/CHCHD10/JUN/BNIP3L 9 GO:0001952 regulation of cell-matrix adhesion 10/502 128/18722 0.00237171286252066 0.0131869515649286 CD36/RIN2/PEAK1/NRP1/IQGAP1/PLEKHA2/DUSP3/LRP1/MACF1/PIK3R1 10 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 10/502 128/18722 0.00237171286252066 0.0131869515649286 ZEB2/SPRED1/DAB2/HSPA1A/SDCBP/ENG/SNX6/TGFB1/CITED2/SKIL 10 GO:0002287 alpha-beta T cell activation involved in immune response 7/502 69/18722 0.00245619184671405 0.013607596985508 LGALS9/HLA-DRA/HLA-DRB1/CD86/PTGER4/STAT3/NFKBIZ 7 GO:0002293 alpha-beta T cell differentiation involved in immune response 7/502 69/18722 0.00245619184671405 0.013607596985508 LGALS9/HLA-DRA/HLA-DRB1/CD86/PTGER4/STAT3/NFKBIZ 7 GO:1901224 positive regulation of NIK/NF-kappaB signaling 7/502 69/18722 0.00245619184671405 0.013607596985508 CD14/LAPTM5/TLR4/TLR7/LGALS9/CD86/HAVCR2 7 GO:0001894 tissue homeostasis 16/502 268/18722 0.00248006619877808 0.0137070325394832 SPP1/CSF1R/TLR4/ALDH1A1/TPP1/B2M/RB1/SYK/PECAM1/ACTB/PDK4/OAS1/LIPA/ACP5/DRAM2/ATP6AP1 16 GO:0051348 negative regulation of transferase activity 16/502 268/18722 0.00248006619877808 0.0137070325394832 SPRED1/APOE/PTPRC/RB1/ZFP36/SLC8A1/LYN/PYCARD/DUSP1/SNX6/DTX3L/GADD45B/PTPN6/DUSP3/ADAR/PRKAR1A 16 GO:0043393 regulation of protein binding 13/502 196/18722 0.00249590082752555 0.0137780873844072 APOE/DAB2/PLXND1/CTSZ/B2M/IFIT1/ARRB2/NRP1/ACTB/DTX3L/TMBIM6/LRP1/STK4 13 GO:0002220 innate immune response activating cell surface receptor signaling pathway 4/502 22/18722 0.00254480103282619 0.0139647088705266 TYROBP/SYK/LYN/CLEC7A 4 GO:0032069 regulation of nuclease activity 4/502 22/18722 0.00254480103282619 0.0139647088705266 OAS2/HSPA1A/OAS1/TMBIM6 4 GO:0032727 positive regulation of interferon-alpha production 4/502 22/18722 0.00254480103282619 0.0139647088705266 TLR4/TLR7/IFIH1/STAT1 4 GO:0032816 positive regulation of natural killer cell activation 4/502 22/18722 0.00254480103282619 0.0139647088705266 GAS6/TYROBP/HLA-E/LAMP1 4 GO:0050860 negative regulation of T cell receptor signaling pathway 4/502 22/18722 0.00254480103282619 0.0139647088705266 LAPTM5/PRNP/PTPN6/DUSP3 4 GO:0051385 response to mineralocorticoid 5/502 36/18722 0.00257794428651645 0.0140723592838793 CYBB/CYBA/FOS/FOXO3/FOSB 5 GO:0031103 axon regeneration 6/502 52/18722 0.00258267034846812 0.0140723592838793 SPP1/GRN/JAK2/TSPO/KLF4/LRP1 6 GO:0043277 apoptotic cell clearance 6/502 52/18722 0.00258267034846812 0.0140723592838793 C2/CCL2/GAS6/TYROBP/CD36/LRP1 6 GO:0045010 actin nucleation 6/502 52/18722 0.00258267034846812 0.0140723592838793 FCHSD2/ACTR2/GMFG/CYFIP1/WAS/GSN 6 GO:0048260 positive regulation of receptor-mediated endocytosis 6/502 52/18722 0.00258267034846812 0.0140723592838793 DAB2/B2M/SYK/ARRB2/CD63/PPT1 6 GO:0060147 regulation of posttranscriptional gene silencing 6/502 52/18722 0.00258267034846812 0.0140723592838793 NEAT1/ZFP36/TGFB1/STAT3/DDX5/ADAR 6 GO:0042594 response to starvation 13/502 197/18722 0.00260885816079373 0.014198326884508 GAS6/IFI16/ZFP36/PDK4/CPEB4/XBP1/ATG7/GLUL/UCP2/FOXO3/LAMP2/SESN1/JUN 13 GO:0010810 regulation of cell-substrate adhesion 14/502 221/18722 0.00264781482460373 0.0143501820973978 CD36/RIN2/PEAK1/NRP1/PREX1/JAK2/IQGAP1/LGALS1/PLEKHA2/DUSP3/LRP1/MACF1/PIK3R1/STK4 14 GO:0014910 regulation of smooth muscle cell migration 8/502 89/18722 0.00267012027320295 0.0143501820973978 MEF2C/IGF1/AIF1/TLR4/NRP1/IQGAP1/LRP1/GNA13 8 GO:0046330 positive regulation of JNK cascade 8/502 89/18722 0.00267012027320295 0.0143501820973978 FCGR2B/TLR4/PYCARD/SDCBP/GADD45B/NCF1/TAOK3/TAOK1 8 GO:0050871 positive regulation of B cell activation 11/502 152/18722 0.0026843328099798 0.0143501820973978 MEF2C/CD28/CD74/NCKAP1L/TLR4/PTPRC/SYK/CD81/TNFSF13B/XBP1/TGFB1 11 GO:0051092 positive regulation of NF-kappaB transcription factor activity 11/502 152/18722 0.0026843328099798 0.0143501820973978 CD36/ICAM1/TLR4/LGALS9/HSPA1A/MTDH/CLEC7A/PYCARD/TRIM22/STAT3/TRIM38 11 GO:0002357 defense response to tumor cell 3/502 11/18722 0.0026925979378602 0.0143501820973978 LAPTM5/SPI1/KLF4 3 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 3/502 11/18722 0.0026925979378602 0.0143501820973978 CR1/FCGR2B/PTPN6 3 GO:0007042 lysosomal lumen acidification 3/502 11/18722 0.0026925979378602 0.0143501820973978 GRN/PPT1/ATP6AP2 3 GO:0019372 lipoxygenase pathway 3/502 11/18722 0.0026925979378602 0.0143501820973978 ALOX5AP/ALOX5/GPX1 3 GO:0035457 cellular response to interferon-alpha 3/502 11/18722 0.0026925979378602 0.0143501820973978 GAS6/IFIT3/IFNAR1 3 GO:0045060 negative thymic T cell selection 3/502 11/18722 0.0026925979378602 0.0143501820973978 CD28/CD74/PTPRC 3 GO:0046643 regulation of gamma-delta T cell activation 3/502 11/18722 0.0026925979378602 0.0143501820973978 NCKAP1L/PTPRC/SYK 3 GO:0048102 autophagic cell death 3/502 11/18722 0.0026925979378602 0.0143501820973978 LAPTM5/ATG7/LAMP1 3 GO:0097048 dendritic cell apoptotic process 3/502 11/18722 0.0026925979378602 0.0143501820973978 GAS6/LGALS9/LYN 3 GO:1900426 positive regulation of defense response to bacterium 3/502 11/18722 0.0026925979378602 0.0143501820973978 CYBA/HAVCR2/GRN 3 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 3/502 11/18722 0.0026925979378602 0.0143501820973978 CD74/TLR4/LRP1 3 GO:2000644 regulation of receptor catabolic process 3/502 11/18722 0.0026925979378602 0.0143501820973978 APOE/LAPTM5/DTX3L 3 GO:2000668 regulation of dendritic cell apoptotic process 3/502 11/18722 0.0026925979378602 0.0143501820973978 GAS6/LGALS9/LYN 3 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 10/502 131/18722 0.00280942827442503 0.0149555986162143 ZEB2/SPRED1/DAB2/HSPA1A/SDCBP/ENG/SNX6/TGFB1/CITED2/SKIL 10 GO:0014812 muscle cell migration 9/502 110/18722 0.00282659535267286 0.0150124341004187 MEF2C/IGF1/AIF1/TLR4/PLEKHO1/NRP1/IQGAP1/LRP1/GNA13 9 GO:0061387 regulation of extent of cell growth 9/502 110/18722 0.00282659535267286 0.0150124341004187 SPP1/APOE/ARHGAP4/NRP1/CYFIP1/RTN4/LRP1/MACF1/GOLGA4 9 GO:0060966 regulation of gene silencing by RNA 6/502 53/18722 0.00284770865918928 0.0151072250658367 NEAT1/ZFP36/TGFB1/STAT3/DDX5/ADAR 6 GO:0045638 negative regulation of myeloid cell differentiation 8/502 90/18722 0.00286356635683538 0.0151565880626092 C1QC/CCL3/MAFB/TLR4/ZFP36L1/ZFP36/LYN/PIK3R1 8 GO:0046849 bone remodeling 8/502 90/18722 0.00286356635683538 0.0151565880626092 SPP1/CSF1R/TPP1/SYK/PDK4/ACP5/TGFB1/ATP6AP1 8 GO:0010634 positive regulation of epithelial cell migration 12/502 176/18722 0.00287762600162808 0.0152135975811788 ENPP2/LGMN/TMSB4X/RIN2/ADAM9/GRN/NRP1/TGFBR2/TGFB1/HIF1A/RTN4/RHOB 12 GO:0150116 regulation of cell-substrate junction organization 7/502 71/18722 0.00289236042796495 0.0152740403421985 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1/PIK3R1 7 GO:0002369 T cell cytokine production 5/502 37/18722 0.00291611673532226 0.0153294954745463 TNFRSF1B/B2M/HLA-A/RSAD2/CD81 5 GO:0002724 regulation of T cell cytokine production 5/502 37/18722 0.00291611673532226 0.0153294954745463 TNFRSF1B/B2M/HLA-A/RSAD2/CD81 5 GO:0003176 aortic valve development 5/502 37/18722 0.00291611673532226 0.0153294954745463 TNFRSF1B/RB1/RBPJ/TNFRSF1A/TGFB1 5 GO:0032570 response to progesterone 5/502 37/18722 0.00291611673532226 0.0153294954745463 TXNIP/FOS/FOSB/TSPO/TGFB1 5 GO:0050770 regulation of axonogenesis 11/502 154/18722 0.0029703147169001 0.0155966809084902 SPP1/PLXND1/ARHGAP4/NRP1/CYFIP1/RTN4/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 11 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 9/502 111/18722 0.00300491834939387 0.015729668057653 IGF1/CD28/PDGFC/PIK3AP1/HCST/JAK2/KLF4/NCF1/PTPN6 9 GO:0043405 regulation of MAP kinase activity 12/502 177/18722 0.00301408551073936 0.015729668057653 PDGFC/APOE/TLR4/SYK/ADAM9/LYN/IQGAP1/DUSP1/TGFB1/PTPN6/TAOK3/AKAP13 12 GO:0002758 innate immune response-activating signal transduction 4/502 23/18722 0.00301604314032386 0.015729668057653 TYROBP/SYK/LYN/CLEC7A 4 GO:0006929 substrate-dependent cell migration 4/502 23/18722 0.00301604314032386 0.015729668057653 PTPRC/NRP1/SDCBP/STK4 4 GO:0060396 growth hormone receptor signaling pathway 4/502 23/18722 0.00301604314032386 0.015729668057653 LYN/JAK2/STAT3/PIK3R1 4 GO:0072677 eosinophil migration 4/502 23/18722 0.00301604314032386 0.015729668057653 CCL2/CCL3/CCL4/PTGER4 4 GO:0007346 regulation of mitotic cell cycle 23/502 457/18722 0.00304105943210004 0.015842275825332 CCL2/IGF1/CD28/AIF1/LGMN/GPNMB/ZFP36L1/RB1/TIMP2/ATM/BTG2/IQGAP1/DUSP1/SDCBP/ZFP36L2/KLF4/NABP1/TGFB1/PTPN6/DUSP3/TAOK3/TAOK1/KMT2E 23 GO:0050769 positive regulation of neurogenesis 14/502 225/18722 0.00311466084396209 0.0162074477662189 PLXND1/TNFRSF1B/NRP1/LYN/ACTR2/TSPO/CYFIP1/TGFB1/HIF1A/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 14 GO:0006665 sphingolipid metabolic process 11/502 155/18722 0.00312222819570623 0.0162103564908384 ENPP2/PSAP/ASAH1/SGMS1/PLA2G15/ST8SIA4/PPT1/SPTLC2/ACER3/SERINC1/HEXA 11 GO:0034614 cellular response to reactive oxygen species 11/502 155/18722 0.00312222819570623 0.0162103564908384 CD36/KLF2/FOS/SOD2/SIRPA/FOXO3/KLF4/NCF1/SETX/JUN/RHOB 11 GO:0030330 DNA damage response, signal transduction by p53 class mediator 7/502 72/18722 0.00313152250667206 0.0162244910398295 SPRED1/CD74/ATM/CD44/FOXO3/DDX5/SP100 7 GO:1902743 regulation of lamellipodium organization 6/502 54/18722 0.0031325800644366 0.0162244910398295 ENPP2/ACTR2/CD44/CYFIP1/WAS/PIK3R1 6 GO:0046328 regulation of JNK cascade 10/502 133/18722 0.00313547232806043 0.0162244910398295 FCGR2B/TLR4/SIRPA/PYCARD/SDCBP/GADD45B/NCF1/DUSP3/TAOK3/TAOK1 10 GO:0048015 phosphatidylinositol-mediated signaling 12/502 178/18722 0.00315574303195926 0.016311136609881 CSF1R/IGF1/CD28/PDGFC/ZFP36L1/PIK3AP1/HCST/JAK2/KLF4/NCF1/PTPN6/PIK3R1 12 GO:0002526 acute inflammatory response 9/502 112/18722 0.00319200106019262 0.0164801304737177 CD163/FCGR2B/ICAM1/ALOX5AP/HLA-E/PLSCR1/NUPR1/STAT3/PRCP 9 GO:0006887 exocytosis 19/502 352/18722 0.00320451227055641 0.016526280672903 CCL3/CD84/FCGR2B/PLEK/CCR1/NCKAP1L/ITGB2/LGALS9/ITGAM/ITSN1/TNFAIP2/SPI1/SYK/LYN/SDCBP/LAMP1/GNAI2/ATP6AP1/RAB8B 19 GO:0010742 macrophage derived foam cell differentiation 5/502 38/18722 0.00328519447302885 0.0168858995913683 CD36/MSR1/ABCA1/TGFB1/STAT1 5 GO:0090077 foam cell differentiation 5/502 38/18722 0.00328519447302885 0.0168858995913683 CD36/MSR1/ABCA1/TGFB1/STAT1 5 GO:1903580 positive regulation of ATP metabolic process 5/502 38/18722 0.00328519447302885 0.0168858995913683 IGF1/TMSB4X/NUPR1/STAT3/HIF1A 5 GO:0031346 positive regulation of cell projection organization 19/502 353/18722 0.00330507731286007 0.0169692426740185 ENPP2/APOE/PLXND1/CCDC88A/GRN/NRP1/LYN/IQGAP1/ACTR2/CYFIP1/SETX/LRP1/MACF1/GOLGA4/EPS8/PIK3R1/SKIL/PLXNB2/RAB8B 19 GO:0032147 activation of protein kinase activity 10/502 134/18722 0.00330942563735414 0.0169727305968961 IGF1/GAS6/PDGFC/NCKAP1L/CD86/CCDC88A/PRNP/JAK2/TGFBR2/CAB39 10 GO:0006643 membrane lipid metabolic process 13/502 203/18722 0.00337779244458595 0.0173041725898722 ENPP2/PSAP/ASAH1/SGMS1/PLA2G15/ST8SIA4/PPT1/SPTLC2/ACER3/FUCA1/MGST2/SERINC1/HEXA 13 GO:0071347 cellular response to interleukin-1 9/502 113/18722 0.00338813748230471 0.0173379690189619 CCL2/CCL3/ICAM1/CCL4/KLF2/SIRPA/PYCARD/EGR1/HIF1A 9 GO:0061098 positive regulation of protein tyrosine kinase activity 6/502 55/18722 0.00343817874417265 0.0175695228560342 CSF1R/GAS6/FCGR1A/PRNP/NCF1/ABI1 6 GO:0001837 epithelial to mesenchymal transition 11/502 157/18722 0.00344478107013035 0.0175695228560342 SPRED1/DAB2/RBPJ/TGFBR2/SDCBP/ENG/TGFB1/HIF1A/DDX17/DDX5/RTN4 11 GO:1990845 adaptive thermogenesis 11/502 157/18722 0.00344478107013035 0.0175695228560342 GATM/CMKLR1/PDGFC/CD36/TLR4/ALDH1A1/RB1/RBPJ/SYK/JAK2/UCP2 11 GO:0043409 negative regulation of MAPK cascade 12/502 180/18722 0.00345522634694192 0.0175884227133008 SPRED1/APOE/TLR4/PTPRC/LYN/SIRPA/DUSP1/RNF149/KLF4/PTPN6/DUSP3/TAOK3 12 GO:0001101 response to acid chemical 10/502 135/18722 0.00349096775802862 0.0175884227133008 CYBB/PDGFC/ICAM1/CYBA/KLF2/LYN/CPEB4/XBP1/SESN1/TMBIM6 10 GO:0032088 negative regulation of NF-kappaB transcription factor activity 8/502 93/18722 0.00351002062984602 0.0175884227133008 TMIGD3/CMKLR1/TMSB4X/HAVCR2/SPI1/ARRB2/PYCARD/KLF4 8 GO:0002424 T cell mediated immune response to tumor cell 3/502 12/18722 0.00351912234282439 0.0175884227133008 HLA-A/HLA-DRB1/AHR 3 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 3/502 12/18722 0.00351912234282439 0.0175884227133008 CD28/HLA-E/CD81 3 GO:0014889 muscle atrophy 3/502 12/18722 0.00351912234282439 0.0175884227133008 GATM/FOXO3/GSN 3 GO:0035739 CD4-positive, alpha-beta T cell proliferation 3/502 12/18722 0.00351912234282439 0.0175884227133008 LGALS9/CD81/TGFBR2 3 GO:0043380 regulation of memory T cell differentiation 3/502 12/18722 0.00351912234282439 0.0175884227133008 HLA-DRA/HLA-DRB1/FGL2 3 GO:0043383 negative T cell selection 3/502 12/18722 0.00351912234282439 0.0175884227133008 CD28/CD74/PTPRC 3 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 3/502 12/18722 0.00351912234282439 0.0175884227133008 CD68/CD36/TLR4 3 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 3/502 12/18722 0.00351912234282439 0.0175884227133008 PLXND1/NRP1/PLXNB2 3 GO:1902950 regulation of dendritic spine maintenance 3/502 12/18722 0.00351912234282439 0.0175884227133008 FCGR2B/APOE/PRNP 3 GO:2000508 regulation of dendritic cell chemotaxis 3/502 12/18722 0.00351912234282439 0.0175884227133008 GAS6/LGALS9/SPI1 3 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 3/502 12/18722 0.00351912234282439 0.0175884227133008 LGALS9/CD81/TGFBR2 3 GO:2000727 positive regulation of cardiac muscle cell differentiation 3/502 12/18722 0.00351912234282439 0.0175884227133008 MEF2C/ARRB2/TGFB1 3 GO:0002726 positive regulation of T cell cytokine production 4/502 24/18722 0.00354353868759108 0.0175884227133008 B2M/HLA-A/RSAD2/CD81 4 GO:0035458 cellular response to interferon-beta 4/502 24/18722 0.00354353868759108 0.0175884227133008 IFI16/IFITM2/OAS1/STAT1 4 GO:0038095 Fc-epsilon receptor signaling pathway 4/502 24/18722 0.00354353868759108 0.0175884227133008 FCER1G/SYK/LYN/MAP3K1 4 GO:0043302 positive regulation of leukocyte degranulation 4/502 24/18722 0.00354353868759108 0.0175884227133008 ITGB2/ITGAM/SYK/LAMP1 4 GO:0050855 regulation of B cell receptor signaling pathway 4/502 24/18722 0.00354353868759108 0.0175884227133008 FCGR2B/LYN/CD81/CMTM3 4 GO:0060149 negative regulation of posttranscriptional gene silencing 4/502 24/18722 0.00354353868759108 0.0175884227133008 NEAT1/TGFB1/STAT3/ADAR 4 GO:0060967 negative regulation of gene silencing by RNA 4/502 24/18722 0.00354353868759108 0.0175884227133008 NEAT1/TGFB1/STAT3/ADAR 4 GO:0071378 cellular response to growth hormone stimulus 4/502 24/18722 0.00354353868759108 0.0175884227133008 LYN/JAK2/STAT3/PIK3R1 4 GO:0090023 positive regulation of neutrophil chemotaxis 4/502 24/18722 0.00354353868759108 0.0175884227133008 C3AR1/CD74/NCKAP1L/C5AR1 4 GO:2000679 positive regulation of transcription regulatory region DNA binding 4/502 24/18722 0.00354353868759108 0.0175884227133008 IGF1/RB1/KLF4/TGFB1 4 GO:0002244 hematopoietic progenitor cell differentiation 9/502 114/18722 0.00359362557884634 0.0178179120340227 CSF1R/PLEK/PTPRC/SPI1/N4BP2L2/TGFB1/PTPN6/CITED2/ADAR 9 GO:0008361 regulation of cell size 12/502 181/18722 0.00361334418602501 0.0178964991483423 SPP1/APOE/PLEK/ARHGAP4/NRP1/CYFIP1/TMEM123/MSN/RTN4/LRP1/MACF1/GOLGA4 12 GO:0007040 lysosome organization 7/502 74/18722 0.00365488042066244 0.0180442655560133 LAPTM5/TPP1/ABCA1/GRN/PPT1/ATP6AP2/GAA 7 GO:0080171 lytic vacuole organization 7/502 74/18722 0.00365488042066244 0.0180442655560133 LAPTM5/TPP1/ABCA1/GRN/PPT1/ATP6AP2/GAA 7 GO:1903201 regulation of oxidative stress-induced cell death 7/502 74/18722 0.00365488042066244 0.0180442655560133 TLR4/SOD2/ATG7/GPX1/FOXO3/MCL1/HIF1A 7 GO:0099024 plasma membrane invagination 10/502 136/18722 0.003680328486741 0.0181433714759821 AIF1/FCGR2B/CD36/MSR1/NCKAP1L/ITGB2/FCGR1A/ITGAM/ABCA1/GSN 10 GO:0002701 negative regulation of production of molecular mediator of immune response 5/502 39/18722 0.00368672053338158 0.0181433714759821 CR1/FCGR2B/BST2/TGFB1/TMBIM6 5 GO:0034314 Arp2/3 complex-mediated actin nucleation 5/502 39/18722 0.00368672053338158 0.0181433714759821 FCHSD2/ACTR2/GMFG/CYFIP1/WAS 5 GO:0071214 cellular response to abiotic stimulus 18/502 331/18722 0.00375874901954007 0.0184520811795606 TLR4/TLR7/IFI16/CYBA/ZFP36L1/MCOLN1/PTGER4/NAMPT/ATM/EGR1/ENG/TSPO/TNFRSF1A/TIMP1/RHOB/MAP3K1/CAB39/PIK3R1 18 GO:0104004 cellular response to environmental stimulus 18/502 331/18722 0.00375874901954007 0.0184520811795606 TLR4/TLR7/IFI16/CYBA/ZFP36L1/MCOLN1/PTGER4/NAMPT/ATM/EGR1/ENG/TSPO/TNFRSF1A/TIMP1/RHOB/MAP3K1/CAB39/PIK3R1 18 GO:0031529 ruffle organization 6/502 56/18722 0.00376540523854414 0.0184520811795606 CSF1R/AIF1/PLEK/ICAM1/CYFIP1/EPS8 6 GO:0043388 positive regulation of DNA binding 6/502 56/18722 0.00376540523854414 0.0184520811795606 IGF1/RB1/JAK2/KLF4/TGFB1/CALM2 6 GO:0051260 protein homooligomerization 12/502 182/18722 0.00377724406626032 0.0184905090481696 KCTD12/ALOX5AP/B2M/MCOLN1/SAMHD1/NINJ1/PRNP/RNF213/EHD4/SOD2/PYCARD/GLS 12 GO:0042692 muscle cell differentiation 20/502 384/18722 0.00378639451204001 0.0185157093157475 MEF2C/IGF1/PLD3/CD53/RB1/RBPJ/ARRB2/NINJ1/PLEKHO1/MEF2A/SLC8A1/CD81/SOD2/XBP1/GPX1/QKI/ENG/TGFB1/PRKAR1A/AKAP13 20 GO:0051209 release of sequestered calcium ion into cytosol 9/502 115/18722 0.00380876713038487 0.0186054453486382 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/SLC8A1/LYN/PTPN6/CALM2 9 GO:0045732 positive regulation of protein catabolic process 14/502 231/18722 0.00393955941349333 0.0191869258179125 APOE/DAB2/LAPTM5/CTSC/TNFRSF1B/ADAM9/WWP1/HSPA1A/CD81/ATG7/MSN/NUPR1/LRP1/HERPUD1 14 GO:0033077 T cell differentiation in thymus 7/502 75/18722 0.00394024633095912 0.0191869258179125 CD28/MAFB/CD74/PTPRC/B2M/ZFP36L1/ZFP36L2 7 GO:0034121 regulation of toll-like receptor signaling pathway 7/502 75/18722 0.00394024633095912 0.0191869258179125 CD36/CYBA/RSAD2/ARRB2/NINJ1/LYN/RTN4 7 GO:0060402 calcium ion transport into cytosol 11/502 160/18722 0.00397814123153423 0.019351084476422 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/PRNP/SLC8A1/LYN/PTPN6/TMBIM6/CALM2 11 GO:0030516 regulation of axon extension 8/502 95/18722 0.00400012910434201 0.0194172059146759 APOE/ARHGAP4/NRP1/CYFIP1/RTN4/LRP1/MACF1/GOLGA4 8 GO:0036473 cell death in response to oxidative stress 8/502 95/18722 0.00400012910434201 0.0194172059146759 TLR4/JAK2/SOD2/ATG7/GPX1/FOXO3/MCL1/HIF1A 8 GO:0043200 response to amino acid 9/502 116/18722 0.00403386758118771 0.019539970084371 CYBB/PDGFC/ICAM1/CYBA/LYN/CPEB4/XBP1/SESN1/TMBIM6 9 GO:0051283 negative regulation of sequestering of calcium ion 9/502 116/18722 0.00403386758118771 0.019539970084371 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/SLC8A1/LYN/PTPN6/CALM2 9 GO:0032273 positive regulation of protein polymerization 10/502 138/18722 0.00408343967224298 0.0197594057780293 NCKAP1L/ICAM1/HSPA1A/FCHSD2/PYCARD/ACTR2/GMFG/CYFIP1/WAS/GSN 10 GO:0030501 positive regulation of bone mineralization 5/502 40/18722 0.00412223328280149 0.0198616707063873 MEF2C/ALOX5/SLC8A1/ISG15/TGFB1 5 GO:0048143 astrocyte activation 4/502 25/18722 0.00413033446163955 0.0198616707063873 C1QA/C5AR1/GRN/LRP1 4 GO:1901623 regulation of lymphocyte chemotaxis 4/502 25/18722 0.00413033446163955 0.0198616707063873 CCL2/CCL3/CCL4/ADAM10 4 GO:1903055 positive regulation of extracellular matrix organization 4/502 25/18722 0.00413033446163955 0.0198616707063873 RUNX1/RB1/COLGALT1/TGFB1 4 GO:1903901 negative regulation of viral life cycle 4/502 25/18722 0.00413033446163955 0.0198616707063873 BST2/IFITM2/IFITM3/GSN 4 GO:1905048 regulation of metallopeptidase activity 4/502 25/18722 0.00413033446163955 0.0198616707063873 TIMP2/TIMP1/STAT3/LRP1 4 GO:0051146 striated muscle cell differentiation 16/502 283/18722 0.0042233779620541 0.0202880025466898 MEF2C/IGF1/PLD3/CD53/RB1/RBPJ/ARRB2/PLEKHO1/MEF2A/SLC8A1/CD81/XBP1/GPX1/TGFB1/PRKAR1A/AKAP13 16 GO:0055017 cardiac muscle tissue growth 8/502 96/18722 0.00426416283120943 0.0204626735032934 MEF2C/IGF1/RUNX1/RBPJ/TGFBR2/CITED2/PRKAR1A/AKAP13 8 GO:0030301 cholesterol transport 9/502 117/18722 0.00426923588033524 0.0204657877538143 PLTP/APOE/CD36/MSR1/NPC2/ABCA1/TSPO/LRP1/STX12 9 GO:0051051 negative regulation of transport 23/502 470/18722 0.00427828634740151 0.0204879426946992 CD84/FCGR2B/APOE/CD74/CD36/NCKAP1L/BST2/ICAM1/LGALS9/TNFRSF1B/RSAD2/SPI1/SIRPA/SDCBP/UCP2/PLSCR1/CYFIP1/TNFRSF1A/GNAI2/TMBIM6/SP100/CAB39/CALM2 23 GO:0045598 regulation of fat cell differentiation 10/502 139/18722 0.00429766416858327 0.0205594565086517 CMKLR1/METRNL/ZFP36L1/ZFP36/ALOX5/XBP1/ZFP36L2/TGFB1/CREBL2/STK4 10 GO:0048588 developmental cell growth 14/502 234/18722 0.00441413785453803 0.021094836482534 SPP1/IGF1/APOE/ARHGAP4/NRP1/ITSN2/IQGAP1/TGFBR2/CYFIP1/RTN4/LRP1/MACF1/GOLGA4/AKAP13 14 GO:0002638 negative regulation of immunoglobulin production 3/502 13/18722 0.00448449931377915 0.0212085683840225 CR1/FCGR2B/TMBIM6 3 GO:0042492 gamma-delta T cell differentiation 3/502 13/18722 0.00448449931377915 0.0212085683840225 NCKAP1L/PTPRC/SYK 3 GO:0043379 memory T cell differentiation 3/502 13/18722 0.00448449931377915 0.0212085683840225 HLA-DRA/HLA-DRB1/FGL2 3 GO:0046512 sphingosine biosynthetic process 3/502 13/18722 0.00448449931377915 0.0212085683840225 ASAH1/SPTLC2/ACER3 3 GO:0046520 sphingoid biosynthetic process 3/502 13/18722 0.00448449931377915 0.0212085683840225 ASAH1/SPTLC2/ACER3 3 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 3/502 13/18722 0.00448449931377915 0.0212085683840225 TLR4/HSPA1A/SLC15A3 3 GO:0071801 regulation of podosome assembly 3/502 13/18722 0.00448449931377915 0.0212085683840225 LCP1/MSN/GSN 3 GO:1900272 negative regulation of long-term synaptic potentiation 3/502 13/18722 0.00448449931377915 0.0212085683840225 TYROBP/APOE/PRNP 3 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 3/502 13/18722 0.00448449931377915 0.0212085683840225 PLXND1/NRP1/PLXNB2 3 GO:1902947 regulation of tau-protein kinase activity 3/502 13/18722 0.00448449931377915 0.0212085683840225 RB1/C5AR1/EGR1 3 GO:0006826 iron ion transport 6/502 58/18722 0.00448836758494552 0.0212085683840225 FTL/B2M/MCOLN1/CLTC/FTH1/SLC11A2 6 GO:0031345 negative regulation of cell projection organization 12/502 186/18722 0.00449370774306815 0.0212121347137074 SPP1/PMP22/APOE/CTSZ/B2M/ARHGAP4/PRNP/NRP1/VIM/LGALS1/RTN4/LRP1 12 GO:0051282 regulation of sequestering of calcium ion 9/502 118/18722 0.00451518431788989 0.0212917865999578 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/SLC8A1/LYN/PTPN6/CALM2 9 GO:0032386 regulation of intracellular transport 18/502 337/18722 0.00452613181767433 0.0213216759557652 GAS6/DAB2/IFI27/CD36/ITGB2/ITGAM/MX2/LCP1/PRNP/CD81/JAK2/LAMP1/TGFB1/MSN/DNAJC13/SP100/BNIP3L/PIK3R1 18 GO:0014909 smooth muscle cell migration 8/502 97/18722 0.0045414097600607 0.0213718835707434 MEF2C/IGF1/AIF1/TLR4/NRP1/IQGAP1/LRP1/GNA13 8 GO:0072331 signal transduction by p53 class mediator 11/502 163/18722 0.00457541022515076 0.0215100078267758 SPRED1/CD74/IFI16/ATM/PYCARD/CD44/FOXO3/SGK1/NUPR1/DDX5/SP100 11 GO:0045930 negative regulation of mitotic cell cycle 14/502 235/18722 0.00458225392013505 0.0215203113041064 CCL2/GPNMB/ZFP36L1/RB1/TIMP2/ATM/BTG2/DUSP1/ZFP36L2/KLF4/NABP1/TGFB1/TAOK3/TAOK1 14 GO:0050856 regulation of T cell receptor signaling pathway 5/502 41/18722 0.00459326299340831 0.0215283025405338 LAPTM5/PRNP/CD81/PTPN6/DUSP3 5 GO:1905314 semi-lunar valve development 5/502 41/18722 0.00459326299340831 0.0215283025405338 TNFRSF1B/RB1/RBPJ/TNFRSF1A/TGFB1 5 GO:0002407 dendritic cell chemotaxis 4/502 26/18722 0.00477938707410947 0.0222205473415381 GAS6/CCR1/LGALS9/SPI1 4 GO:0002418 immune response to tumor cell 4/502 26/18722 0.00477938707410947 0.0222205473415381 HLA-A/HLA-DRB1/HAVCR2/AHR 4 GO:0002710 negative regulation of T cell mediated immunity 4/502 26/18722 0.00477938707410947 0.0222205473415381 FCGR2B/NCKAP1L/PTPRC/AHR 4 GO:0010875 positive regulation of cholesterol efflux 4/502 26/18722 0.00477938707410947 0.0222205473415381 PLTP/APOE/ABCA1/LRP1 4 GO:0032682 negative regulation of chemokine production 4/502 26/18722 0.00477938707410947 0.0222205473415381 LGALS9/OAS1/SIRPA/KLF4 4 GO:0045672 positive regulation of osteoclast differentiation 4/502 26/18722 0.00477938707410947 0.0222205473415381 TYROBP/CCR1/FOS/ATP6AP1 4 GO:0046697 decidualization 4/502 26/18722 0.00477938707410947 0.0222205473415381 SPP1/CTSB/JUNB/CITED2 4 GO:0051016 barbed-end actin filament capping 4/502 26/18722 0.00477938707410947 0.0222205473415381 CAPG/CAPZA2/EPS8/GSN 4 GO:0001836 release of cytochrome c from mitochondria 6/502 59/18722 0.00488592424972105 0.0226702964686154 IGF1/ARRB2/SOD2/PYCARD/GPX1/JUN 6 GO:0035306 positive regulation of dephosphorylation 6/502 59/18722 0.00488592424972105 0.0226702964686154 MEF2C/PLEK/PTPRC/JAK2/TGFB1/CALM2 6 GO:0009636 response to toxic substance 15/502 262/18722 0.00491388368425831 0.0227771802839469 SCN9A/CCL3/APOE/CD36/ALDH1A1/ALOX5AP/CCL4/LYN/FOS/SOD2/GPX1/NUPR1/MGST2/SESN1/AHR 15 GO:0033673 negative regulation of kinase activity 14/502 237/18722 0.00493404012929699 0.0228477173554834 SPRED1/APOE/PTPRC/RB1/SLC8A1/LYN/PYCARD/DUSP1/SNX6/GADD45B/PTPN6/DUSP3/ADAR/PRKAR1A 14 GO:0097553 calcium ion transmembrane import into cytosol 10/502 142/18722 0.00499391383962163 0.0231018454220896 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/PRNP/SLC8A1/LYN/PTPN6/CALM2 10 GO:0051897 positive regulation of protein kinase B signaling 9/502 120/18722 0.00504008645736859 0.0232921478039831 GAS6/CD28/CCL3/ARRB2/MTDH/GPX1/ENG/TGFB1/RTN4 9 GO:0032965 regulation of collagen biosynthetic process 5/502 42/18722 0.0051013285298106 0.0234347028588916 RUNX1/ARRB2/VIM/ENG/TGFB1 5 GO:0033003 regulation of mast cell activation 5/502 42/18722 0.0051013285298106 0.0234347028588916 CD84/LGALS9/SYK/LYN/PLSCR1 5 GO:0033574 response to testosterone 5/502 42/18722 0.0051013285298106 0.0234347028588916 SPP1/DUSP1/TSPO/MSN/NCOA4 5 GO:0045773 positive regulation of axon extension 5/502 42/18722 0.0051013285298106 0.0234347028588916 NRP1/CYFIP1/LRP1/MACF1/GOLGA4 5 GO:0071312 cellular response to alkaloid 5/502 42/18722 0.0051013285298106 0.0234347028588916 AIF1/ICAM1/SLC8A1/ATG7/SLC1A3 5 GO:1904037 positive regulation of epithelial cell apoptotic process 5/502 42/18722 0.0051013285298106 0.0234347028588916 CCL2/ARRB2/JAK2/FOXO3/GSN 5 GO:0072594 establishment of protein localization to organelle 21/502 422/18722 0.00513078494164213 0.0235466380357505 CD68/CD36/LAPTM5/MAN1A1/TXNIP/IL10RA/SYK/JAK2/VPS13C/TSPO/LAMP1/TGFB1/LAMP2/NCOA4/STAT3/BNIP3L/TRAM1/RANBP2/PIK3R1/HERPUD1/RAB8B 21 GO:0030307 positive regulation of cell growth 11/502 166/18722 0.00524178212588841 0.0240321943650741 IGF1/CYBA/CXCL16/NRP1/ITSN2/SDCBP/CYFIP1/LRP1/MACF1/GOLGA4/ADAM10 11 GO:1901184 regulation of ERBB signaling pathway 7/502 79/18722 0.00525351135990117 0.0240621223276265 LGMN/CCDC88A/RBPJ/SNX6/NCF1/RTN4/DUSP3 7 GO:0031102 neuron projection regeneration 6/502 60/18722 0.00530874768508794 0.0242670620466569 SPP1/GRN/JAK2/TSPO/KLF4/LRP1 6 GO:0060038 cardiac muscle cell proliferation 6/502 60/18722 0.00530874768508794 0.0242670620466569 MEF2C/RUNX1/RBPJ/TGFBR2/CITED2/PRKAR1A 6 GO:0003206 cardiac chamber morphogenesis 9/502 121/18722 0.0053196799046125 0.0242690722275517 MEF2C/RBPJ/NRP1/TGFBR2/ENG/TGFB1/DHRS3/HIF1A/CITED2 9 GO:0038127 ERBB signaling pathway 9/502 121/18722 0.0053196799046125 0.0242690722275517 LGMN/CCDC88A/RBPJ/IQGAP1/SNX6/TGFB1/NCF1/RTN4/DUSP3 9 GO:0071375 cellular response to peptide hormone stimulus 16/502 290/18722 0.00532682404081116 0.024277722180091 CYBA/MYO5A/ZFP36L1/NR4A2/LYN/JAK2/PDK4/XBP1/UCP2/CYFIP1/NR4A1/STAT1/STAT3/GNAI2/PIK3R1/RAB8B 16 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 4/502 27/18722 0.00549355505583287 0.0248661308104529 FCGR2B/PTPRC/SYK/LYN 4 GO:0010758 regulation of macrophage chemotaxis 4/502 27/18722 0.00549355505583287 0.0248661308104529 CSF1R/C3AR1/CMKLR1/C5AR1 4 GO:0036037 CD8-positive, alpha-beta T cell activation 4/502 27/18722 0.00549355505583287 0.0248661308104529 RUNX1/NCKAP1L/HLA-A/HLA-E 4 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 4/502 27/18722 0.00549355505583287 0.0248661308104529 FCGR2B/PTPRC/SYK/LYN 4 GO:0060142 regulation of syncytium formation by plasma membrane fusion 4/502 27/18722 0.00549355505583287 0.0248661308104529 TYROBP/CD53/ADAM9/PLEKHO1 4 GO:0071624 positive regulation of granulocyte chemotaxis 4/502 27/18722 0.00549355505583287 0.0248661308104529 C3AR1/CD74/NCKAP1L/C5AR1 4 GO:1903203 regulation of oxidative stress-induced neuron death 4/502 27/18722 0.00549355505583287 0.0248661308104529 TLR4/ATG7/MCL1/HIF1A 4 GO:0060485 mesenchyme development 16/502 291/18722 0.00550202083225246 0.0248801059335287 MEF2C/SPRED1/DAB2/ZFP36L1/RBPJ/NRP1/TGFBR2/SDCBP/ENG/TGFB1/STAT1/HIF1A/DDX17/DDX5/RTN4/CITED2 16 GO:0001771 immunological synapse formation 3/502 14/18722 0.00559496967726057 0.0250797768672552 HAVCR2/CD81/MSN 3 GO:0032688 negative regulation of interferon-beta production 3/502 14/18722 0.00559496967726057 0.0250797768672552 SIRPA/PYCARD/REL 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/502 14/18722 0.00559496967726057 0.0250797768672552 SPRED1/ATM/DDX5 3 GO:0043922 negative regulation by host of viral transcription 3/502 14/18722 0.00559496967726057 0.0250797768672552 CCL3/CCL4/JUN 3 GO:0045579 positive regulation of B cell differentiation 3/502 14/18722 0.00559496967726057 0.0250797768672552 NCKAP1L/SYK/XBP1 3 GO:0070278 extracellular matrix constituent secretion 3/502 14/18722 0.00559496967726057 0.0250797768672552 TNFRSF1B/ENG/TNFRSF1A 3 GO:0072160 nephron tubule epithelial cell differentiation 3/502 14/18722 0.00559496967726057 0.0250797768672552 MEF2C/MTSS1/STAT1 3 GO:0090715 immunological memory formation process 3/502 14/18722 0.00559496967726057 0.0250797768672552 HLA-DRA/HLA-DRB1/FGL2 3 GO:1905049 negative regulation of metallopeptidase activity 3/502 14/18722 0.00559496967726057 0.0250797768672552 TIMP2/TIMP1/LRP1 3 GO:0051208 sequestering of calcium ion 9/502 122/18722 0.00561113262185903 0.0251035778614312 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/SLC8A1/LYN/PTPN6/CALM2 9 GO:0051928 positive regulation of calcium ion transport 9/502 122/18722 0.00561113262185903 0.0251035778614312 CCL2/ATP1B1/CCL3/CCR1/CCL4/VMP1/ARRB2/TSPO/CALM2 9 GO:0071229 cellular response to acid chemical 7/502 80/18722 0.0056277940463935 0.0251537925204022 CYBB/PDGFC/CYBA/KLF2/CPEB4/XBP1/SESN1 7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5/502 43/18722 0.00564793415535004 0.0252194434388506 CD74/IFI16/PYCARD/CD44/NUPR1 5 GO:0016482 cytosolic transport 11/502 168/18722 0.00572706025526259 0.0255481010037076 DAB2/LAPTM5/CLTC/VPS13C/EPS15/ACTR2/SNX6/LAMP1/MSN/DNAJC13/SNX2 11 GO:0034113 heterotypic cell-cell adhesion 6/502 61/18722 0.0057577501613036 0.0256355652032632 ITGB2/PTPRC/NINJ1/SIRPA/CD44/KLF4 6 GO:0043954 cellular component maintenance 6/502 61/18722 0.0057577501613036 0.0256355652032632 CSF1R/FCGR2B/APOE/MTSS1/PRNP/CHCHD10 6 GO:0150115 cell-substrate junction organization 8/502 101/18722 0.00579107843042832 0.0257591623261167 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1/PIK3R1/RAB8B 8 GO:0006690 icosanoid metabolic process 9/502 123/18722 0.00591477098765997 0.0262840831785927 HPGDS/CD74/ALOX5AP/TBXAS1/SYK/ALOX5/GPX1/TNFRSF1A/MGST2 9 GO:0048708 astrocyte differentiation 7/502 81/18722 0.00602167986143924 0.0266312533833823 C1QA/TLR4/C5AR1/GRN/VIM/STAT3/LRP1 7 GO:0051817 modulation of process of other organism involved in symbiotic interaction 7/502 81/18722 0.00602167986143924 0.0266312533833823 CD4/CCL3/APOE/IFI27/CCL4/ATG7/JUN 7 GO:0060968 regulation of gene silencing 7/502 81/18722 0.00602167986143924 0.0266312533833823 NEAT1/ZFP36/TGFB1/STAT3/DDX5/ATF7IP/ADAR 7 GO:0071260 cellular response to mechanical stimulus 7/502 81/18722 0.00602167986143924 0.0266312533833823 TLR4/TLR7/CYBA/PTGER4/ENG/TNFRSF1A/MAP3K1 7 GO:2000106 regulation of leukocyte apoptotic process 7/502 81/18722 0.00602167986143924 0.0266312533833823 MEF2C/GAS6/CD74/LGALS9/LYN/TSC22D3/HIF1A 7 GO:0010639 negative regulation of organelle organization 18/502 347/18722 0.00608904972927578 0.02690348046574 IGF1/TMSB4X/ARRB2/HSPA1A/ATM/DUSP1/GPX1/TSPO/GMFG/WAS/NUPR1/CAPG/CAPZA2/EPS8/PIK3R1/GSN/TAOK1/PRKAR1A 18 GO:0010508 positive regulation of autophagy 9/502 124/18722 0.00623092364612294 0.0273894629210165 MTDH/TRIM22/ATG7/FOXO3/SPTLC2/HIF1A/SESN1/BNIP3L/TRIM38 9 GO:0045576 mast cell activation 6/502 62/18722 0.00623384232525888 0.0273894629210165 CD84/LGALS9/LCP2/SYK/LYN/PLSCR1 6 GO:0070265 necrotic cell death 6/502 62/18722 0.00623384232525888 0.0273894629210165 NINJ1/ASAH1/PYGL/TSPO/TMEM123/NUPR1 6 GO:0045124 regulation of bone resorption 5/502 44/18722 0.00623456646256602 0.0273894629210165 SPP1/CSF1R/SYK/PDK4/ATP6AP1 5 GO:0046006 regulation of activated T cell proliferation 5/502 44/18722 0.00623456646256602 0.0273894629210165 IGF1/LGALS9/PRNP/PYCARD/PRKAR1A 5 GO:1903573 negative regulation of response to endoplasmic reticulum stress 5/502 44/18722 0.00623456646256602 0.0273894629210165 ALOX5/HSPA1A/XBP1/TMBIM6/HERPUD1 5 GO:0010575 positive regulation of vascular endothelial growth factor production 4/502 28/18722 0.0062755919164292 0.027465362540588 C3AR1/C5AR1/TGFB1/HIF1A 4 GO:0034123 positive regulation of toll-like receptor signaling pathway 4/502 28/18722 0.0062755919164292 0.027465362540588 CYBA/RSAD2/NINJ1/RTN4 4 GO:0045671 negative regulation of osteoclast differentiation 4/502 28/18722 0.0062755919164292 0.027465362540588 CCL3/MAFB/TLR4/PIK3R1 4 GO:1902624 positive regulation of neutrophil migration 4/502 28/18722 0.0062755919164292 0.027465362540588 C3AR1/CD74/NCKAP1L/C5AR1 4 GO:2001020 regulation of response to DNA damage stimulus 13/502 219/18722 0.00635805769204709 0.0277999762603117 SPRED1/CD74/PARP9/ATM/ACTR2/IER3/CD44/DTX3L/WAS/MCL1/DDX5/FEM1B/SKIL 13 GO:0060395 SMAD protein signal transduction 7/502 82/18722 0.0064357804010994 0.0281132390325645 DAB2/FOS/JAK2/VIM/TGFB1/JUN/LRP1 7 GO:1904375 regulation of protein localization to cell periphery 9/502 125/18722 0.00655992131425495 0.0286284867922108 DAB2/PRNP/ACTB/CLTC/STX7/TGFB1/LRP1/PIK3R1/ADAM10 9 GO:0010212 response to ionizing radiation 10/502 148/18722 0.00664991235977066 0.0289665673976451 ICAM1/IFI16/CYBA/PTPRC/NAMPT/ATM/EGR1/GPX1/NABP1/RHOB 10 GO:2001056 positive regulation of cysteine-type endopeptidase activity 10/502 148/18722 0.00664991235977066 0.0289665673976451 LGMN/LAPTM5/IFI16/LGALS9/SYK/CTSD/CLEC7A/JAK2/PYCARD/GSN 10 GO:0022617 extracellular matrix disassembly 6/502 63/18722 0.00673793190621561 0.0292948054493923 CTSS/CST3/LCP1/TGFB1/LRP1/ADAM10 6 GO:2000242 negative regulation of reproductive process 6/502 63/18722 0.00673793190621561 0.0292948054493923 IGF1/DUSP1/PRKACB/ARHGDIB/TIMP1/PRKAR1A 6 GO:0001678 cellular glucose homeostasis 11/502 172/18722 0.00680341414754057 0.0294770757321075 GAS6/ICAM1/CYBA/HLA-DRB1/XBP1/UCP2/FOXO3/LGALS1/HIF1A/LRP1/PIK3R1 11 GO:0002730 regulation of dendritic cell cytokine production 3/502 15/18722 0.00685596215766499 0.0294770757321075 BST2/TLR4/CLEC7A 3 GO:0030852 regulation of granulocyte differentiation 3/502 15/18722 0.00685596215766499 0.0294770757321075 C1QC/RUNX1/EVI2B 3 GO:0034380 high-density lipoprotein particle assembly 3/502 15/18722 0.00685596215766499 0.0294770757321075 APOE/ABCA1/PRKACB 3 GO:0042159 lipoprotein catabolic process 3/502 15/18722 0.00685596215766499 0.0294770757321075 APOE/CTSD/PPT1 3 GO:0046007 negative regulation of activated T cell proliferation 3/502 15/18722 0.00685596215766499 0.0294770757321075 LGALS9/PRNP/PRKAR1A 3 GO:0140374 antiviral innate immune response 3/502 15/18722 0.00685596215766499 0.0294770757321075 IFIT1/MX1/OAS1 3 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/502 15/18722 0.00685596215766499 0.0294770757321075 ZFP36L1/ZFP36/ZFP36L2 3 GO:1905146 lysosomal protein catabolic process 3/502 15/18722 0.00685596215766499 0.0294770757321075 TPP1/LAMP2/LRP1 3 GO:1905288 vascular associated smooth muscle cell apoptotic process 3/502 15/18722 0.00685596215766499 0.0294770757321075 IGF1/SOD2/STK4 3 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 3/502 15/18722 0.00685596215766499 0.0294770757321075 IGF1/SOD2/STK4 3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 5/502 45/18722 0.00686269143179415 0.0294770757321075 JAK2/SOD2/GPX1/MCL1/HIF1A 5 GO:0071354 cellular response to interleukin-6 5/502 45/18722 0.00686269143179415 0.0294770757321075 ICAM1/SPI1/SELPLG/JAK2/STAT3 5 GO:0060419 heart growth 8/502 104/18722 0.00688819878361523 0.0295317957117739 MEF2C/IGF1/RUNX1/RBPJ/TGFBR2/CITED2/PRKAR1A/AKAP13 8 GO:1903076 regulation of protein localization to plasma membrane 8/502 104/18722 0.00688819878361523 0.0295317957117739 DAB2/PRNP/ACTB/CLTC/STX7/TGFB1/LRP1/PIK3R1 8 GO:0048679 regulation of axon regeneration 4/502 29/18722 0.00712814010522026 0.0304195351722776 SPP1/GRN/KLF4/LRP1 4 GO:0060969 negative regulation of gene silencing 4/502 29/18722 0.00712814010522026 0.0304195351722776 NEAT1/TGFB1/STAT3/ADAR 4 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/502 29/18722 0.00712814010522026 0.0304195351722776 SOD2/GPX1/MCL1/HIF1A 4 GO:1902430 negative regulation of amyloid-beta formation 4/502 29/18722 0.00712814010522026 0.0304195351722776 IGF1/APOE/PRNP/RTN4 4 GO:2000406 positive regulation of T cell migration 4/502 29/18722 0.00712814010522026 0.0304195351722776 AIF1/TNFRSF14/PYCARD/ADAM10 4 GO:0048247 lymphocyte chemotaxis 6/502 64/18722 0.00727092243931488 0.0310002647043969 CCL2/GAS6/CCL3/CCL4/CXCL16/ADAM10 6 GO:0032231 regulation of actin filament bundle assembly 8/502 105/18722 0.00728669919338274 0.0310103684163648 PLEK/MTSS1/CCDC88A/PTGER4/NRP1/GPR65/WAS/PIK3R1 8 GO:2001022 positive regulation of response to DNA damage stimulus 8/502 105/18722 0.00728669919338274 0.0310103684163648 SPRED1/PARP9/ATM/ACTR2/DTX3L/WAS/DDX5/SKIL 8 GO:0010921 regulation of phosphatase activity 7/502 84/18722 0.00732707587307143 0.031124933874039 MEF2C/PLEK/NCKAP1L/PTPRC/JAK2/GNAI2/CALM2 7 GO:0098586 cellular response to virus 7/502 84/18722 0.00732707587307143 0.031124933874039 TLR7/LGALS9/POU2F2/OAS1/IFIH1/HIF1A/ADAR 7 GO:0030198 extracellular matrix organization 16/502 301/18722 0.00752469319026916 0.0318959283956325 GAS6/OLFML2B/RUNX1/CTSS/TGFBI/TNFRSF1B/RB1/CST3/COLGALT1/LCP1/ENG/TNFRSF1A/TGFB1/P4HA1/LRP1/ADAM10 16 GO:0042886 amide transport 16/502 301/18722 0.00752469319026916 0.0318959283956325 PLTP/FOLR2/CD209/CD74/HLA-DRB1/PSAP/ITSN1/ABCA1/ALOX5/SLC15A3/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 16 GO:0045926 negative regulation of growth 14/502 249/18722 0.00752925936187434 0.0318959283956325 SPP1/LGMN/BST2/ARHGAP4/RB1/HSPA1A/NRP1/TGFBR2/PPT1/TGFB1/HIF1A/RTN4/CITED2/STK4 14 GO:0071333 cellular response to glucose stimulus 10/502 151/18722 0.0076234706678869 0.0322654851872322 GAS6/ICAM1/CYBA/HLA-DRB1/XBP1/UCP2/FOXO3/LGALS1/HIF1A/LRP1 10 GO:0046822 regulation of nucleocytoplasmic transport 8/502 106/18722 0.00770233445720942 0.0325694691033371 GAS6/IFI27/CD36/MX2/JAK2/TGFB1/SP100/PIK3R1 8 GO:0043062 extracellular structure organization 16/502 302/18722 0.00775605966357491 0.0327666958937877 GAS6/OLFML2B/RUNX1/CTSS/TGFBI/TNFRSF1B/RB1/CST3/COLGALT1/LCP1/ENG/TNFRSF1A/TGFB1/P4HA1/LRP1/ADAM10 16 GO:0010507 negative regulation of autophagy 7/502 85/18722 0.00780549594688332 0.0328256584093475 IL10RA/NAMPT/ATG7/TSPO/MCL1/NUPR1/STAT3 7 GO:0032092 positive regulation of protein binding 7/502 85/18722 0.00780549594688332 0.0328256584093475 APOE/PLXND1/B2M/NRP1/DTX3L/LRP1/STK4 7 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 7/502 85/18722 0.00780549594688332 0.0328256584093475 CSF1R/IGF1/PARP14/LYN/PARP9/JAK2/TNFRSF1A 7 GO:0055072 iron ion homeostasis 7/502 85/18722 0.00780549594688332 0.0328256584093475 FTL/B2M/FTH1/SLC11A2/NCOA4/HIF1A/ATP6AP1 7 GO:0097006 regulation of plasma lipoprotein particle levels 7/502 85/18722 0.00780549594688332 0.0328256584093475 PLTP/APOE/CD36/MSR1/ABCA1/LIPA/PRKACB 7 GO:1903829 positive regulation of cellular protein localization 15/502 276/18722 0.00781984415334266 0.0328561299303934 TYROBP/ITGB2/ITGAM/CCDC88A/PRNP/CD81/PARP9/JAK2/IQGAP1/DTX3L/TGFB1/MSN/RTN4/LRP1/PIK3R1 15 GO:0060389 pathway-restricted SMAD protein phosphorylation 6/502 65/18722 0.00783371200927038 0.032884529723126 DAB2/TGFBR2/SDCBP/ENG/TGFB1/LRP1 6 GO:0016485 protein processing 13/502 225/18722 0.00790638999022918 0.0331595286444245 RUNX1/LGMN/CTSS/CTSZ/IFI16/SRGN/PRNP/PYCARD/CPM/PRKACB/ATP6AP2/GSN/ADAM10 13 GO:0043534 blood vessel endothelial cell migration 11/502 176/18722 0.00803196012785626 0.0335644464966223 MEF2C/SPRED1/TMSB4X/APOE/NRP1/GPX1/KLF4/NR4A1/TGFB1/HIF1A/PRCP 11 GO:0032480 negative regulation of type I interferon production 4/502 30/18722 0.00805372581306761 0.0335644464966223 HAVCR2/SIRPA/PYCARD/REL 4 GO:0034390 smooth muscle cell apoptotic process 4/502 30/18722 0.00805372581306761 0.0335644464966223 IGF1/ARRB2/SOD2/STK4 4 GO:0034391 regulation of smooth muscle cell apoptotic process 4/502 30/18722 0.00805372581306761 0.0335644464966223 IGF1/ARRB2/SOD2/STK4 4 GO:0043032 positive regulation of macrophage activation 4/502 30/18722 0.00805372581306761 0.0335644464966223 CCL3/TLR4/CTSC/HAVCR2 4 GO:0043304 regulation of mast cell degranulation 4/502 30/18722 0.00805372581306761 0.0335644464966223 CD84/LGALS9/SYK/LYN 4 GO:2000637 positive regulation of gene silencing by miRNA 4/502 30/18722 0.00805372581306761 0.0335644464966223 ZFP36/TGFB1/STAT3/DDX5 4 GO:0031532 actin cytoskeleton reorganization 8/502 107/18722 0.00813554878712928 0.0338749313134654 CSF1R/PLEK/NRP1/GPR65/GMFG/ARHGDIB/EPS8/GSN 8 GO:0045229 external encapsulating structure organization 16/502 304/18722 0.00823589572226639 0.0339546852738628 GAS6/OLFML2B/RUNX1/CTSS/TGFBI/TNFRSF1B/RB1/CST3/COLGALT1/LCP1/ENG/TNFRSF1A/TGFB1/P4HA1/LRP1/ADAM10 16 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 5/502 47/18722 0.00824916348943098 0.0339546852738628 GAS6/LAPTM5/SYK/HSPA1A/PYCARD 5 GO:0045911 positive regulation of DNA recombination 5/502 47/18722 0.00824916348943098 0.0339546852738628 CD28/PTPRC/ACTR2/WAS/TGFB1 5 GO:0050798 activated T cell proliferation 5/502 47/18722 0.00824916348943098 0.0339546852738628 IGF1/LGALS9/PRNP/PYCARD/PRKAR1A 5 GO:0002371 dendritic cell cytokine production 3/502 16/18722 0.00827214230515422 0.0339546852738628 BST2/TLR4/CLEC7A 3 GO:0002713 negative regulation of B cell mediated immunity 3/502 16/18722 0.00827214230515422 0.0339546852738628 CR1/FCGR2B/PTPN6 3 GO:0002890 negative regulation of immunoglobulin mediated immune response 3/502 16/18722 0.00827214230515422 0.0339546852738628 CR1/FCGR2B/PTPN6 3 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 3/502 16/18722 0.00827214230515422 0.0339546852738628 RBPJ/TGFBR2/ENG 3 GO:0009299 mRNA transcription 3/502 16/18722 0.00827214230515422 0.0339546852738628 C5AR1/STAT3/DDX5 3 GO:0035751 regulation of lysosomal lumen pH 3/502 16/18722 0.00827214230515422 0.0339546852738628 GRN/PPT1/ATP6AP2 3 GO:0051014 actin filament severing 3/502 16/18722 0.00827214230515422 0.0339546852738628 GMFG/CAPG/GSN 3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 3/502 16/18722 0.00827214230515422 0.0339546852738628 APOE/TNFRSF1B/ADAM9 3 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 3/502 16/18722 0.00827214230515422 0.0339546852738628 TLR4/HSPA1A/SLC15A3 3 GO:0097202 activation of cysteine-type endopeptidase activity 3/502 16/18722 0.00827214230515422 0.0339546852738628 LGMN/IFI16/PYCARD 3 GO:0097284 hepatocyte apoptotic process 3/502 16/18722 0.00827214230515422 0.0339546852738628 RB1/GSN/STK4 3 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/502 16/18722 0.00827214230515422 0.0339546852738628 LGALS9/JAK2/GSN 3 GO:0022406 membrane docking 7/502 86/18722 0.00830657977374951 0.0340658138593664 PLEK/ICAM1/VMP1/STX7/MSN/STX12/RAB8B 7 GO:0061448 connective tissue development 14/502 252/18722 0.00832330619668643 0.0341041757890801 MAF/MEF2C/RUNX1/TGFBI/TRPS1/SPI1/EGR1/XBP1/TGFBR2/CD44/TGFB1/SPTLC2/TIMP1/HIF1A 14 GO:0071331 cellular response to hexose stimulus 10/502 153/18722 0.00833121964145951 0.0341063912047714 GAS6/ICAM1/CYBA/HLA-DRB1/XBP1/UCP2/FOXO3/LGALS1/HIF1A/LRP1 10 GO:0006956 complement activation 9/502 130/18722 0.00840928006919518 0.0343473042011875 C1QA/C1QB/C1QC/VSIG4/A2M/C2/CR1/CFD/SERPING1 9 GO:0015918 sterol transport 9/502 130/18722 0.00840928006919518 0.0343473042011875 PLTP/APOE/CD36/MSR1/NPC2/ABCA1/TSPO/LRP1/STX12 9 GO:0042093 T-helper cell differentiation 6/502 66/18722 0.00842719201650406 0.0343473042011875 HLA-DRA/HLA-DRB1/CD86/PTGER4/STAT3/NFKBIZ 6 GO:0051893 regulation of focal adhesion assembly 6/502 66/18722 0.00842719201650406 0.0343473042011875 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1 6 GO:0090109 regulation of cell-substrate junction assembly 6/502 66/18722 0.00842719201650406 0.0343473042011875 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1 6 GO:0071326 cellular response to monosaccharide stimulus 10/502 154/18722 0.00870350470566504 0.035427591118607 GAS6/ICAM1/CYBA/HLA-DRB1/XBP1/UCP2/FOXO3/LGALS1/HIF1A/LRP1 10 GO:0009266 response to temperature stimulus 11/502 178/18722 0.00870755968479381 0.035427591118607 CD14/IGF1/TFEC/METRNL/ARRB2/HSPA1A/LYN/FOS/SOD2/ATM/UCP2 11 GO:0046683 response to organophosphorus 9/502 131/18722 0.00882238389012085 0.0358317365019307 ZFP36L1/ITPR2/SLC8A1/FOS/DUSP1/FOSB/STAT1/AHR/JUN 9 GO:0050853 B cell receptor signaling pathway 9/502 131/18722 0.00882238389012085 0.0358317365019307 MEF2C/FCGR2B/NCKAP1L/PTPRC/SYK/LYN/CD81/CMTM3/PTPN6 9 GO:0051262 protein tetramerization 7/502 87/18722 0.00883093713750344 0.0358350133316587 B2M/HLA-DRB1/MCOLN1/SAMHD1/SOD2/GLS/STK4 7 GO:0042149 cellular response to glucose starvation 5/502 48/18722 0.00901031485627735 0.0363243083927443 IFI16/CPEB4/XBP1/FOXO3/SESN1 5 GO:0045912 negative regulation of carbohydrate metabolic process 5/502 48/18722 0.00901031485627735 0.0363243083927443 PLEK/CLTC/TGFB1/NUPR1/STAT3 5 GO:0120009 intermembrane lipid transfer 5/502 48/18722 0.00901031485627735 0.0363243083927443 PLTP/APOE/NPC2/ABCA1/TSPO 5 GO:0006879 cellular iron ion homeostasis 6/502 67/18722 0.00905224596782809 0.0363243083927443 FTL/FTH1/SLC11A2/NCOA4/HIF1A/ATP6AP1 6 GO:0002230 positive regulation of defense response to virus by host 4/502 31/18722 0.00905475455790048 0.0363243083927443 PARP9/PYCARD/DTX3L/STAT1 4 GO:0002828 regulation of type 2 immune response 4/502 31/18722 0.00905475455790048 0.0363243083927443 CD74/CD86/RSAD2/CD81 4 GO:0033006 regulation of mast cell activation involved in immune response 4/502 31/18722 0.00905475455790048 0.0363243083927443 CD84/LGALS9/SYK/LYN 4 GO:0036475 neuron death in response to oxidative stress 4/502 31/18722 0.00905475455790048 0.0363243083927443 TLR4/ATG7/MCL1/HIF1A 4 GO:0060055 angiogenesis involved in wound healing 4/502 31/18722 0.00905475455790048 0.0363243083927443 ALOX5/XBP1/GPX1/PRCP 4 GO:0060148 positive regulation of posttranscriptional gene silencing 4/502 31/18722 0.00905475455790048 0.0363243083927443 ZFP36/TGFB1/STAT3/DDX5 4 GO:0060390 regulation of SMAD protein signal transduction 4/502 31/18722 0.00905475455790048 0.0363243083927443 DAB2/JAK2/TGFB1/LRP1 4 GO:0070723 response to cholesterol 4/502 31/18722 0.00905475455790048 0.0363243083927443 CCL3/ABCA1/TGFBR2/TGFB1 4 GO:0001936 regulation of endothelial cell proliferation 11/502 179/18722 0.00906144658132877 0.0363243083927443 MEF2C/CCL2/EGFL7/APOE/CYBA/ALOX5/NRP1/NR4A1/STAT1/STAT3/HIF1A 11 GO:1901991 negative regulation of mitotic cell cycle phase transition 11/502 179/18722 0.00906144658132877 0.0363243083927443 CCL2/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/NABP1/TAOK3/TAOK1 11 GO:1903364 positive regulation of cellular protein catabolic process 10/502 155/18722 0.00908842032704151 0.0363916403799299 APOE/DAB2/LAPTM5/CTSC/HSPA1A/CD81/MSN/NUPR1/LRP1/HERPUD1 10 GO:0033157 regulation of intracellular protein transport 13/502 229/18722 0.00909397671405079 0.0363916403799299 GAS6/IFI27/CD36/ITGB2/ITGAM/LCP1/PRNP/CD81/JAK2/TGFB1/SP100/BNIP3L/PIK3R1 13 GO:0007611 learning or memory 14/502 255/18722 0.00918224835113476 0.036713120892264 MEF2C/GATM/LGMN/APOE/B2M/PRNP/FOS/SLC11A2/BTG2/ACTR2/SGK1/PPT1/HIF1A/JUN 14 GO:0007260 tyrosine phosphorylation of STAT protein 7/502 88/18722 0.00937917558720757 0.0374681055841297 CSF1R/IGF1/PARP14/LYN/PARP9/JAK2/TNFRSF1A 7 GO:0045055 regulated exocytosis 13/502 230/18722 0.00941167104719205 0.0375654790891376 CCL3/CD84/FCGR2B/PLEK/NCKAP1L/ITGB2/LGALS9/ITGAM/SPI1/SYK/LYN/LAMP1/GNAI2 13 GO:0007033 vacuole organization 11/502 180/18722 0.00942634849007586 0.0375916276854232 LAPTM5/TPP1/VMP1/ABCA1/GRN/ATG7/PPT1/NUPR1/ATP6AP2/GAA/STX12 11 GO:0048259 regulation of receptor-mediated endocytosis 8/502 110/18722 0.00954511279188591 0.0380324649227082 DAB2/BMP2K/B2M/SYK/ARRB2/CD63/SDCBP/PPT1 8 GO:0042176 regulation of protein catabolic process 19/502 391/18722 0.00958806052638511 0.0381707125602904 APOE/DAB2/LAPTM5/CTSC/TNFRSF1B/TIMP2/CST3/ADAM9/WWP1/HSPA1A/CD81/ATG7/SDCBP/GPX1/MSN/NUPR1/TIMP1/LRP1/HERPUD1 19 GO:0042987 amyloid precursor protein catabolic process 6/502 68/18722 0.00970974829362527 0.03858874192982 IGF1/APOE/PRNP/LYN/RTN4/ADAM10 6 GO:0060411 cardiac septum morphogenesis 6/502 68/18722 0.00970974829362527 0.03858874192982 RBPJ/NRP1/TGFBR2/ENG/DHRS3/CITED2 6 GO:0050767 regulation of neurogenesis 18/502 364/18722 0.00973627096809574 0.038660935191769 SPP1/PLXND1/TNFRSF1B/B2M/ARHGAP4/NRP1/LYN/ACTR2/TSPO/CYFIP1/TGFB1/HIF1A/RTN4/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 18 GO:0010823 negative regulation of mitochondrion organization 5/502 49/18722 0.00981856249637002 0.0386709218431856 IGF1/ARRB2/HSPA1A/GPX1/TSPO 5 GO:0045778 positive regulation of ossification 5/502 49/18722 0.00981856249637002 0.0386709218431856 MEF2C/ALOX5/SLC8A1/ISG15/TGFB1 5 GO:0060964 regulation of gene silencing by miRNA 5/502 49/18722 0.00981856249637002 0.0386709218431856 NEAT1/ZFP36/TGFB1/STAT3/DDX5 5 GO:0070169 positive regulation of biomineral tissue development 5/502 49/18722 0.00981856249637002 0.0386709218431856 MEF2C/ALOX5/SLC8A1/ISG15/TGFB1 5 GO:0070741 response to interleukin-6 5/502 49/18722 0.00981856249637002 0.0386709218431856 ICAM1/SPI1/SELPLG/JAK2/STAT3 5 GO:0010715 regulation of extracellular matrix disassembly 3/502 17/18722 0.00984745912911211 0.0386709218431856 CST3/TGFB1/LRP1 3 GO:0034349 glial cell apoptotic process 3/502 17/18722 0.00984745912911211 0.0386709218431856 CCL2/GAS6/RB1 3 GO:0042053 regulation of dopamine metabolic process 3/502 17/18722 0.00984745912911211 0.0386709218431856 ITGB2/ITGAM/NR4A2 3 GO:0042069 regulation of catecholamine metabolic process 3/502 17/18722 0.00984745912911211 0.0386709218431856 ITGB2/ITGAM/NR4A2 3 GO:0055119 relaxation of cardiac muscle 3/502 17/18722 0.00984745912911211 0.0386709218431856 ATP1B1/SLC8A1/GSN 3 GO:0060263 regulation of respiratory burst 3/502 17/18722 0.00984745912911211 0.0386709218431856 GRN/CLEC7A/NCF1 3 GO:0061158 3'-UTR-mediated mRNA destabilization 3/502 17/18722 0.00984745912911211 0.0386709218431856 ZFP36L1/ZFP36/ZFP36L2 3 GO:0070293 renal absorption 3/502 17/18722 0.00984745912911211 0.0386709218431856 GAS6/SGK1/GSN 3 GO:0010039 response to iron ion 4/502 32/18722 0.0101335074997233 0.0395591609229704 C1QA/B2M/SLC11A2/HIF1A 4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 4/502 32/18722 0.0101335074997233 0.0395591609229704 ZEB2/DAB2/SDCBP/CITED2 4 GO:0035767 endothelial cell chemotaxis 4/502 32/18722 0.0101335074997233 0.0395591609229704 LGMN/TMSB4X/NRP1/NR4A1 4 GO:0060317 cardiac epithelial to mesenchymal transition 4/502 32/18722 0.0101335074997233 0.0395591609229704 RBPJ/TGFBR2/ENG/RTN4 4 GO:0090022 regulation of neutrophil chemotaxis 4/502 32/18722 0.0101335074997233 0.0395591609229704 C3AR1/CD74/NCKAP1L/C5AR1 4 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/502 32/18722 0.0101335074997233 0.0395591609229704 HSPA1A/XBP1/TMBIM6/HERPUD1 4 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 4/502 32/18722 0.0101335074997233 0.0395591609229704 ZEB2/DAB2/SDCBP/CITED2 4 GO:0060401 cytosolic calcium ion transport 11/502 182/18722 0.010190072600473 0.0397464383219123 CCL3/CYBA/PTPRC/MCOLN1/ITPR2/PRNP/SLC8A1/LYN/PTPN6/TMBIM6/CALM2 11 GO:0050679 positive regulation of epithelial cell proliferation 12/502 207/18722 0.010224141515069 0.0398457275894771 IGF1/EGFL7/CYBA/C5AR1/GRN/NRP1/XBP1/GLUL/NR4A1/STAT3/HIF1A/RTN4 12 GO:0033344 cholesterol efflux 6/502 69/18722 0.0104005631933311 0.0404651012046675 PLTP/APOE/NPC2/ABCA1/LRP1/STX12 6 GO:0050688 regulation of defense response to virus 6/502 69/18722 0.0104005631933311 0.0404651012046675 IFIT1/PARP9/FGL2/PYCARD/DTX3L/STAT1 6 GO:0045927 positive regulation of growth 14/502 259/18722 0.0104345276506729 0.0405631301781621 MEF2C/IGF1/CYBA/RBPJ/CXCL16/NRP1/ITSN2/TGFBR2/SDCBP/CYFIP1/LRP1/MACF1/GOLGA4/ADAM10 14 GO:0001701 in utero embryonic development 18/502 367/18722 0.0105317376043637 0.0409066483272765 LPAR6/IGF1/ZFP36L1/RBPJ/KLF2/JUNB/TGFBR2/KLF4/N4BP2L2/MBNL1/CMTM3/HIF1A/RTN4/MGAT1/CITED2/SKIL/ADAM10/STK4 18 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 7/502 90/18722 0.0105497110773716 0.0409420834261084 MEF2C/IGF1/JAK2/SOD2/GNAI2/JUN/GNA13 7 GO:0043406 positive regulation of MAP kinase activity 8/502 112/18722 0.0105808650591925 0.0409942058323489 PDGFC/TLR4/SYK/ADAM9/IQGAP1/TGFB1/TAOK3/AKAP13 8 GO:0048640 negative regulation of developmental growth 8/502 112/18722 0.0105808650591925 0.0409942058323489 SPP1/LGMN/ARHGAP4/NRP1/TGFBR2/RTN4/CITED2/STK4 8 GO:0110151 positive regulation of biomineralization 5/502 50/18722 0.0106752298725696 0.0412906466475812 MEF2C/ALOX5/SLC8A1/ISG15/TGFB1 5 GO:2000677 regulation of transcription regulatory region DNA binding 5/502 50/18722 0.0106752298725696 0.0412906466475812 IGF1/TMSB4X/RB1/KLF4/TGFB1 5 GO:0046394 carboxylic acid biosynthetic process 16/502 314/18722 0.0110026805724792 0.0425216377011602 HPGDS/GATM/CD74/ALDH1A1/ALOX5AP/TBXAS1/SYK/ALOX5/PDK4/XBP1/GLUL/QKI/BCAT1/GLS/MGST2/SLC1A3 16 GO:0045123 cellular extravasation 6/502 70/18722 0.0111255435108765 0.0429605711864062 CCL2/ICAM1/PTGER4/SELPLG/PECAM1/SIRPA 6 GO:1990874 vascular associated smooth muscle cell proliferation 7/502 91/18722 0.0111732065278348 0.043108635027326 MEF2C/IGF1/JAK2/SOD2/GNAI2/JUN/GNA13 7 GO:0034110 regulation of homotypic cell-cell adhesion 4/502 33/18722 0.0112921384337734 0.0433865717563419 SYK/LYN/JAK2/LGALS1 4 GO:0070570 regulation of neuron projection regeneration 4/502 33/18722 0.0112921384337734 0.0433865717563419 SPP1/GRN/KLF4/LRP1 4 GO:0150117 positive regulation of cell-substrate junction organization 4/502 33/18722 0.0112921384337734 0.0433865717563419 NRP1/IQGAP1/DUSP3/PIK3R1 4 GO:1902992 negative regulation of amyloid precursor protein catabolic process 4/502 33/18722 0.0112921384337734 0.0433865717563419 IGF1/APOE/PRNP/RTN4 4 GO:1903146 regulation of autophagy of mitochondrion 4/502 33/18722 0.0112921384337734 0.0433865717563419 VPS13C/TSPO/HIF1A/BNIP3L 4 GO:0048738 cardiac muscle tissue development 13/502 236/18722 0.0115043482623925 0.0438210030847885 MEF2C/IGF1/RUNX1/RBPJ/ARRB2/MEF2A/SLC8A1/TGFBR2/ENG/TGFB1/CITED2/PRKAR1A/AKAP13 13 GO:0032964 collagen biosynthetic process 5/502 51/18722 0.011581605005437 0.0438210030847885 RUNX1/ARRB2/VIM/ENG/TGFB1 5 GO:0046850 regulation of bone remodeling 5/502 51/18722 0.011581605005437 0.0438210030847885 SPP1/CSF1R/SYK/PDK4/ATP6AP1 5 GO:0060043 regulation of cardiac muscle cell proliferation 5/502 51/18722 0.011581605005437 0.0438210030847885 MEF2C/RUNX1/RBPJ/TGFBR2/CITED2 5 GO:0002643 regulation of tolerance induction 3/502 18/18722 0.0115851895314951 0.0438210030847885 HLA-B/HAVCR2/TGFBR2 3 GO:0006957 complement activation, alternative pathway 3/502 18/18722 0.0115851895314951 0.0438210030847885 VSIG4/CR1/CFD 3 GO:0034134 toll-like receptor 2 signaling pathway 3/502 18/18722 0.0115851895314951 0.0438210030847885 CYBA/PIK3AP1/LYN 3 GO:0048268 clathrin coat assembly 3/502 18/18722 0.0115851895314951 0.0438210030847885 CLTC/EPS15/FCHO2 3 GO:0050665 hydrogen peroxide biosynthetic process 3/502 18/18722 0.0115851895314951 0.0438210030847885 CYBA/SOD2/STAT3 3 GO:0051447 negative regulation of meiotic cell cycle 3/502 18/18722 0.0115851895314951 0.0438210030847885 DUSP1/PRKACB/PRKAR1A 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/502 18/18722 0.0115851895314951 0.0438210030847885 DAB2/JAK2/TGFB1 3 GO:0071360 cellular response to exogenous dsRNA 3/502 18/18722 0.0115851895314951 0.0438210030847885 IFIT1/IFIH1/COLEC12 3 GO:0071800 podosome assembly 3/502 18/18722 0.0115851895314951 0.0438210030847885 LCP1/MSN/GSN 3 GO:0150078 positive regulation of neuroinflammatory response 3/502 18/18722 0.0115851895314951 0.0438210030847885 CCL3/CTSC/NUPR1 3 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/502 18/18722 0.0115851895314951 0.0438210030847885 ZFP36L1/ZFP36/ZFP36L2 3 GO:1900424 regulation of defense response to bacterium 3/502 18/18722 0.0115851895314951 0.0438210030847885 CYBA/HAVCR2/GRN 3 GO:1902683 regulation of receptor localization to synapse 3/502 18/18722 0.0115851895314951 0.0438210030847885 TYROBP/STX7/ADAM10 3 GO:1903209 positive regulation of oxidative stress-induced cell death 3/502 18/18722 0.0115851895314951 0.0438210030847885 TLR4/FOXO3/MCL1 3 GO:2000641 regulation of early endosome to late endosome transport 3/502 18/18722 0.0115851895314951 0.0438210030847885 DAB2/MSN/DNAJC13 3 GO:0030879 mammary gland development 9/502 137/18722 0.011632137340445 0.0439023621191662 CSF1R/OAS2/JAK2/XBP1/TGFBR2/GPX1/HIF1A/RTN4/USF2 9 GO:0050714 positive regulation of protein secretion 9/502 137/18722 0.011632137340445 0.0439023621191662 IGF1/TLR4/HLA-DRB1/ADAM9/JAK2/GLUL/TGFB1/HIF1A/LRP1 9 GO:0016053 organic acid biosynthetic process 16/502 316/18722 0.0116351699001508 0.0439023621191662 HPGDS/GATM/CD74/ALDH1A1/ALOX5AP/TBXAS1/SYK/ALOX5/PDK4/XBP1/GLUL/QKI/BCAT1/GLS/MGST2/SLC1A3 16 GO:0003205 cardiac chamber development 10/502 161/18722 0.0116782360416233 0.0440289485970247 MEF2C/PLXND1/RBPJ/NRP1/TGFBR2/ENG/TGFB1/DHRS3/HIF1A/CITED2 10 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/502 114/18722 0.0116975810262736 0.0440659689149362 ZEB2/DAB2/RBPJ/JAK2/SDCBP/ENG/TGFB1/CITED2 8 GO:0003208 cardiac ventricle morphogenesis 6/502 71/18722 0.0118855296416068 0.0446648741852745 MEF2C/RBPJ/TGFBR2/ENG/TGFB1/HIF1A 6 GO:0043550 regulation of lipid kinase activity 6/502 71/18722 0.0118855296416068 0.0446648741852745 RB1/LYN/CD81/KLF4/TGFB1/PIK3R1 6 GO:0071230 cellular response to amino acid stimulus 6/502 71/18722 0.0118855296416068 0.0446648741852745 CYBB/PDGFC/CYBA/CPEB4/XBP1/SESN1 6 GO:0032868 response to insulin 14/502 264/18722 0.0121837957373435 0.04574857068259 ICAM1/MYO5A/ZFP36L1/LYN/VPS13C/PDK4/EGR1/XBP1/UCP2/CYFIP1/STAT1/GNAI2/PIK3R1/RAB8B 14 GO:0016236 macroautophagy 15/502 291/18722 0.0123085319244364 0.046179455541316 VMP1/MCOLN1/VPS13C/ATG7/ATP6V0A1/SNX6/WDFY3/SPTLC2/LAMP2/ATP6V0B/NUPR1/HIF1A/SESN1/BNIP3L/STX12 15 GO:0098751 bone cell development 4/502 34/18722 0.0125326714132499 0.0468917780166122 TYROBP/PTPN6/ABI1/ATP6AP1 4 GO:1990000 amyloid fibril formation 4/502 34/18722 0.0125326714132499 0.0468917780166122 APOE/CD36/B2M/GSN 4 GO:0010718 positive regulation of epithelial to mesenchymal transition 5/502 52/18722 0.0125389384795826 0.0468917780166122 DAB2/TGFBR2/SDCBP/ENG/TGFB1 5 GO:0043392 negative regulation of DNA binding 5/502 52/18722 0.0125389384795826 0.0468917780166122 TMSB4X/IFI16/JAK2/SP100/JUN 5 GO:0042246 tissue regeneration 6/502 72/18722 0.0126813484720554 0.04730961131591 IGF1/RUNX1/NINJ1/CD81/TGFBR2/GPX1 6 GO:0055021 regulation of cardiac muscle tissue growth 6/502 72/18722 0.0126813484720554 0.04730961131591 MEF2C/IGF1/RUNX1/RBPJ/TGFBR2/CITED2 6 GO:0071479 cellular response to ionizing radiation 6/502 72/18722 0.0126813484720554 0.04730961131591 IFI16/CYBA/NAMPT/ATM/EGR1/RHOB 6 GO:1990748 cellular detoxification 8/502 116/18722 0.0128987715770159 0.0480819639929699 APOE/CD36/ALDH1A1/ALOX5AP/SOD2/GPX1/MGST2/SESN1 8 GO:0050680 negative regulation of epithelial cell proliferation 10/502 164/18722 0.0131655064382322 0.0490367413713866 MEF2C/CCL2/APOE/B2M/MTSS1/RB1/ALOX5/TGFB1/NUPR1/STAT1 10 GO:0032091 negative regulation of protein binding 7/502 94/18722 0.0132036963190496 0.0491394200900432 DAB2/CTSZ/B2M/IFIT1/ARRB2/ACTB/TMBIM6 7 GO:0006491 N-glycan processing 3/502 19/18722 0.0134879806308485 0.0498365801903394 MAN1A1/MGAT4A/ST8SIA4 3 GO:0006670 sphingosine metabolic process 3/502 19/18722 0.0134879806308485 0.0498365801903394 ASAH1/SPTLC2/ACER3 3 GO:0010885 regulation of cholesterol storage 3/502 19/18722 0.0134879806308485 0.0498365801903394 CD36/MSR1/ABCA1 3 GO:0032695 negative regulation of interleukin-12 production 3/502 19/18722 0.0134879806308485 0.0498365801903394 CMKLR1/ARRB2/ACP5 3 GO:0045019 negative regulation of nitric oxide biosynthetic process 3/502 19/18722 0.0134879806308485 0.0498365801903394 SIRPA/TSPO/ACP5 3 GO:0045780 positive regulation of bone resorption 3/502 19/18722 0.0134879806308485 0.0498365801903394 SPP1/SYK/ATP6AP1 3 GO:0048245 eosinophil chemotaxis 3/502 19/18722 0.0134879806308485 0.0498365801903394 CCL2/CCL3/CCL4 3 GO:0140131 positive regulation of lymphocyte chemotaxis 3/502 19/18722 0.0134879806308485 0.0498365801903394 CCL3/CCL4/ADAM10 3 GO:1904406 negative regulation of nitric oxide metabolic process 3/502 19/18722 0.0134879806308485 0.0498365801903394 SIRPA/TSPO/ACP5 3 GO:0014902 myotube differentiation 8/502 117/18722 0.0135321319951209 0.0499403113754991 MEF2C/IGF1/PLD3/CD53/PLEKHO1/CD81/XBP1/GPX1 8 GO:0007566 embryo implantation 5/502 53/18722 0.0135484415858736 0.0499403113754991 SPP1/VMP1/TGFBR2/ARHGDIB/TIMP1 5 GO:0008347 glial cell migration 5/502 53/18722 0.0135484415858736 0.0499403113754991 CCL2/CCL3/TSPO/RTN4/LRP1 5 GO:0016241 regulation of macroautophagy 9/502 141/18722 0.0138455685253945 0.050874981880051 VPS13C/ATP6V0A1/SNX6/SPTLC2/ATP6V0B/NUPR1/HIF1A/SESN1/BNIP3L 9 GO:0001893 maternal placenta development 4/502 35/18722 0.0138569989556559 0.050874981880051 SPP1/CTSB/JUNB/CITED2 4 GO:0006691 leukotriene metabolic process 4/502 35/18722 0.0138569989556559 0.050874981880051 ALOX5AP/SYK/ALOX5/MGST2 4 GO:0048821 erythrocyte development 4/502 35/18722 0.0138569989556559 0.050874981880051 NCKAP1L/KLF2/SLC11A2/CITED2 4 GO:1905898 positive regulation of response to endoplasmic reticulum stress 4/502 35/18722 0.0138569989556559 0.050874981880051 FCGR2B/XBP1/PIK3R1/HERPUD1 4 GO:0042982 amyloid precursor protein metabolic process 7/502 95/18722 0.0139357982565832 0.0511237135090833 IGF1/APOE/ITM2B/PRNP/LYN/RTN4/ADAM10 7 GO:0022612 gland morphogenesis 8/502 118/18722 0.0141879100080105 0.051966169197986 CSF1R/PLXND1/NRP1/XBP1/TGFBR2/TGFB1/MSN/FEM1B 8 GO:0030203 glycosaminoglycan metabolic process 8/502 118/18722 0.0141879100080105 0.051966169197986 LYVE1/CLTC/CD44/TGFB1/GNS/DSE/FUCA1/HEXA 8 GO:1902904 negative regulation of supramolecular fiber organization 10/502 166/18722 0.0142332140561373 0.0520908609364647 TMSB4X/APOE/GMFG/WAS/CAPG/CAPZA2/EPS8/PIK3R1/GSN/TAOK1 10 GO:0048732 gland development 20/502 436/18722 0.0143513621036885 0.0524817399934096 CSF1R/MAFB/PLXND1/PSAP/RBPJ/OAS2/NRP1/JAK2/XBP1/TGFBR2/UCP2/GPX1/TSPO/TGFB1/MSN/HIF1A/RTN4/USF2/FEM1B/CITED2 20 GO:0016358 dendrite development 13/502 243/18722 0.0143829765436392 0.0525170323512193 MEF2C/APOE/ITSN1/LST1/MEF2A/NRP1/PREX1/SLC11A2/IQGAP1/ACTR2/CYFIP1/ABI1/ADAM10 13 GO:0048844 artery morphogenesis 6/502 74/18722 0.0143837181126232 0.0525170323512193 APOE/RBPJ/NRP1/ENG/LRP1/CITED2 6 GO:0006968 cellular defense response 5/502 54/18722 0.0146112845982651 0.0532218917728933 TYROBP/LY96/C5AR1/NCF2/NCF1 5 GO:0030834 regulation of actin filament depolymerization 5/502 54/18722 0.0146112845982651 0.0532218917728933 PLEK/CAPG/CAPZA2/EPS8/GSN 5 GO:0070228 regulation of lymphocyte apoptotic process 5/502 54/18722 0.0146112845982651 0.0532218917728933 CD74/LGALS9/LYN/TSC22D3/HIF1A 5 GO:1903034 regulation of response to wounding 10/502 167/18722 0.014790731896395 0.0538331437865645 SPP1/APOE/CD36/SERPING1/ALOX5/GRN/CLEC7A/XBP1/KLF4/LRP1 10 GO:0060562 epithelial tube morphogenesis 16/502 325/18722 0.0148433531236156 0.0539821946146585 CSF1R/MEF2C/PLXND1/CTSZ/MTSS1/RBPJ/NRP1/TGFBR2/ENG/TGFB1/PRKACB/HIF1A/RHOB/CITED2/STK4/PLXNB2 16 GO:0050803 regulation of synapse structure or activity 12/502 218/18722 0.0149150536730248 0.0542003442980462 MEF2C/FCGR2B/APOE/SRGN/ITSN1/IL10RA/PRNP/TUBA1A/ACTR2/CYFIP1/PPT1/ADAM10 12 GO:0036314 response to sterol 4/502 36/18722 0.0152668807892983 0.0552822372116752 CCL3/ABCA1/TGFBR2/TGFB1 4 GO:0042092 type 2 immune response 4/502 36/18722 0.0152668807892983 0.0552822372116752 CD74/CD86/RSAD2/CD81 4 GO:0070306 lens fiber cell differentiation 4/502 36/18722 0.0152668807892983 0.0552822372116752 MAF/SPRED1/VIM/SKIL 4 GO:0097009 energy homeostasis 4/502 36/18722 0.0152668807892983 0.0552822372116752 CD36/METRNL/STAT3/PRCP 4 GO:0001935 endothelial cell proliferation 11/502 193/18722 0.0152725246771554 0.0552822372116752 MEF2C/CCL2/EGFL7/APOE/CYBA/ALOX5/NRP1/NR4A1/STAT1/STAT3/HIF1A 11 GO:0048662 negative regulation of smooth muscle cell proliferation 6/502 75/18722 0.0152918460936375 0.0553088975990358 MEF2C/AIF1/APOE/SOD2/KLF4/GNA13 6 GO:2000241 regulation of reproductive process 10/502 168/18722 0.0153643820002642 0.05552783682283 IGF1/LHFPL2/DUSP1/PRKACB/NUPR1/ARHGDIB/TIMP1/CITED2/PRKAR1A/STK4 10 GO:0051962 positive regulation of nervous system development 14/502 272/18722 0.0154473328601525 0.0556135258187554 PLXND1/TNFRSF1B/NRP1/LYN/ACTR2/TSPO/CYFIP1/TGFB1/HIF1A/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 14 GO:0120162 positive regulation of cold-induced thermogenesis 7/502 97/18722 0.0154863281551053 0.0556135258187554 GATM/CMKLR1/PDGFC/CD36/SYK/JAK2/UCP2 7 GO:1990868 response to chemokine 7/502 97/18722 0.0154863281551053 0.0556135258187554 CCL2/CMKLR1/CCL3/CCR1/CCL4/DUSP1/HIF1A 7 GO:1990869 cellular response to chemokine 7/502 97/18722 0.0154863281551053 0.0556135258187554 CCL2/CMKLR1/CCL3/CCR1/CCL4/DUSP1/HIF1A 7 GO:0002834 regulation of response to tumor cell 3/502 20/18722 0.0155578900643144 0.0556135258187554 HLA-DRB1/HAVCR2/AHR 3 GO:0002837 regulation of immune response to tumor cell 3/502 20/18722 0.0155578900643144 0.0556135258187554 HLA-DRB1/HAVCR2/AHR 3 GO:0006883 cellular sodium ion homeostasis 3/502 20/18722 0.0155578900643144 0.0556135258187554 ATP1B1/SLC8A1/SLC1A3 3 GO:0010042 response to manganese ion 3/502 20/18722 0.0155578900643144 0.0556135258187554 ADAM9/SOD2/TSPO 3 GO:0043011 myeloid dendritic cell differentiation 3/502 20/18722 0.0155578900643144 0.0556135258187554 RBPJ/SPI1/TGFBR2 3 GO:0046629 gamma-delta T cell activation 3/502 20/18722 0.0155578900643144 0.0556135258187554 NCKAP1L/PTPRC/SYK 3 GO:0090201 negative regulation of release of cytochrome c from mitochondria 3/502 20/18722 0.0155578900643144 0.0556135258187554 IGF1/ARRB2/GPX1 3 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/502 20/18722 0.0155578900643144 0.0556135258187554 SOD2/GPX1/HIF1A 3 GO:0032411 positive regulation of transporter activity 8/502 120/18722 0.0155684210841522 0.0556135258187554 CCL2/ATP1B1/TMSB4X/CTSS/VMP1/IFNGR2/SGK1/CALM2 8 GO:0048675 axon extension 8/502 120/18722 0.0155684210841522 0.0556135258187554 APOE/ARHGAP4/NRP1/CYFIP1/RTN4/LRP1/MACF1/GOLGA4 8 GO:0071901 negative regulation of protein serine/threonine kinase activity 8/502 120/18722 0.0155684210841522 0.0556135258187554 APOE/RB1/SLC8A1/LYN/PYCARD/DUSP1/PTPN6/PRKAR1A 8 GO:0000768 syncytium formation by plasma membrane fusion 5/502 55/18722 0.0157285951836744 0.0560558407701678 TYROBP/CD53/ADAM9/PLEKHO1/CD81 5 GO:0140253 cell-cell fusion 5/502 55/18722 0.0157285951836744 0.0560558407701678 TYROBP/CD53/ADAM9/PLEKHO1/CD81 5 GO:1902991 regulation of amyloid precursor protein catabolic process 5/502 55/18722 0.0157285951836744 0.0560558407701678 IGF1/APOE/PRNP/LYN/RTN4 5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 6/502 76/18722 0.0162389592437836 0.0578301966603101 CD74/IFI16/PYCARD/CD44/NUPR1/DDX5 6 GO:0043502 regulation of muscle adaptation 7/502 98/18722 0.0163058691793786 0.0580238083260042 IGF1/AIF1/TNFRSF1B/MEF2A/FOXO3/TNFRSF1A/KLF4 7 GO:0061351 neural precursor cell proliferation 9/502 145/18722 0.0163563331876306 0.0581586451391076 CTSZ/C5AR1/LYN/BTG2/FOXO3/GNAI2/HIF1A/ATF5/PLXNB2 9 GO:0006623 protein targeting to vacuole 4/502 37/18722 0.0167639430988712 0.0593850579357484 LAPTM5/VPS13C/LAMP2/NCOA4 4 GO:0043403 skeletal muscle tissue regeneration 4/502 37/18722 0.0167639430988712 0.0593850579357484 IGF1/CD81/TGFBR2/GPX1 4 GO:0060416 response to growth hormone 4/502 37/18722 0.0167639430988712 0.0593850579357484 LYN/JAK2/STAT3/PIK3R1 4 GO:1902745 positive regulation of lamellipodium organization 4/502 37/18722 0.0167639430988712 0.0593850579357484 ENPP2/ACTR2/CYFIP1/PIK3R1 4 GO:0051960 regulation of nervous system development 20/502 443/18722 0.0167654314016618 0.0593850579357484 SPP1/PLXND1/CTSC/TNFRSF1B/B2M/ARHGAP4/TYMP/NRP1/LYN/ACTR2/TSPO/CYFIP1/TGFB1/HIF1A/RTN4/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 20 GO:0010332 response to gamma radiation 5/502 56/18722 0.0169014569430009 0.0597296713661743 CYBA/PTPRC/ATM/EGR1/GPX1 5 GO:0048008 platelet-derived growth factor receptor signaling pathway 5/502 56/18722 0.0169014569430009 0.0597296713661743 PDGFC/TXNIP/NRP1/JAK2/LRP1 5 GO:0071385 cellular response to glucocorticoid stimulus 5/502 56/18722 0.0169014569430009 0.0597296713661743 ICAM1/ZFP36L1/ZFP36/ZFP36L2/FOXO3 5 GO:0051222 positive regulation of protein transport 15/502 303/18722 0.0171761490057922 0.0606540956494617 IGF1/GAS6/ITGB2/TLR4/ITGAM/HLA-DRB1/ADAM9/PRNP/CD81/JAK2/GLUL/TGFB1/HIF1A/LRP1/PIK3R1 15 GO:1901988 negative regulation of cell cycle phase transition 13/502 249/18722 0.0172638896074155 0.060917431978569 CCL2/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/NABP1/TAOK3/FEM1B/ATF5/TAOK1 13 GO:0003177 pulmonary valve development 3/502 21/18722 0.0177964243516385 0.0620943079665922 TNFRSF1B/RBPJ/TNFRSF1A 3 GO:0007252 I-kappaB phosphorylation 3/502 21/18722 0.0177964243516385 0.0620943079665922 TLR4/TLR7/SIRPA 3 GO:0010878 cholesterol storage 3/502 21/18722 0.0177964243516385 0.0620943079665922 CD36/MSR1/ABCA1 3 GO:0032516 positive regulation of phosphoprotein phosphatase activity 3/502 21/18722 0.0177964243516385 0.0620943079665922 PTPRC/JAK2/CALM2 3 GO:0034312 diol biosynthetic process 3/502 21/18722 0.0177964243516385 0.0620943079665922 ASAH1/SPTLC2/ACER3 3 GO:0044342 type B pancreatic cell proliferation 3/502 21/18722 0.0177964243516385 0.0620943079665922 IGFBP4/NR4A1/NUPR1 3 GO:0045056 transcytosis 3/502 21/18722 0.0177964243516385 0.0620943079665922 FCGRT/CLTC/LRP1 3 GO:0046514 ceramide catabolic process 3/502 21/18722 0.0177964243516385 0.0620943079665922 ASAH1/ACER3/HEXA 3 GO:0046519 sphingoid metabolic process 3/502 21/18722 0.0177964243516385 0.0620943079665922 ASAH1/SPTLC2/ACER3 3 GO:0046597 negative regulation of viral entry into host cell 3/502 21/18722 0.0177964243516385 0.0620943079665922 IFITM2/IFITM3/GSN 3 GO:0090026 positive regulation of monocyte chemotaxis 3/502 21/18722 0.0177964243516385 0.0620943079665922 AIF1/LGMN/CCR1 3 GO:0097062 dendritic spine maintenance 3/502 21/18722 0.0177964243516385 0.0620943079665922 FCGR2B/APOE/PRNP 3 GO:1905209 positive regulation of cardiocyte differentiation 3/502 21/18722 0.0177964243516385 0.0620943079665922 MEF2C/ARRB2/TGFB1 3 GO:2001014 regulation of skeletal muscle cell differentiation 3/502 21/18722 0.0177964243516385 0.0620943079665922 MEF2C/DDX17/DDX5 3 GO:0010811 positive regulation of cell-substrate adhesion 8/502 123/18722 0.0178178545802774 0.0620943079665922 CD36/RIN2/NRP1/PREX1/JAK2/IQGAP1/PLEKHA2/STK4 8 GO:0042770 signal transduction in response to DNA damage 10/502 172/18722 0.0178256033246075 0.0620943079665922 SPRED1/CD74/ATM/CD44/FOXO3/DDX5/SP100/TAOK3/FEM1B/TAOK1 10 GO:1990138 neuron projection extension 10/502 172/18722 0.0178256033246075 0.0620943079665922 APOE/ARHGAP4/NRP1/ITSN2/IQGAP1/CYFIP1/RTN4/LRP1/MACF1/GOLGA4 10 GO:0060840 artery development 7/502 100/18722 0.0180362225311159 0.0627335078413099 APOE/PLXND1/RBPJ/NRP1/ENG/LRP1/CITED2 7 GO:0110020 regulation of actomyosin structure organization 7/502 100/18722 0.0180362225311159 0.0627335078413099 CCDC88A/PTGER4/NRP1/GPR65/WAS/PIK3R1/AKAP13 7 GO:0006949 syncytium formation 5/502 57/18722 0.0181309080811164 0.0628737487130769 TYROBP/CD53/ADAM9/PLEKHO1/CD81 5 GO:0034205 amyloid-beta formation 5/502 57/18722 0.0181309080811164 0.0628737487130769 IGF1/APOE/PRNP/RTN4/ADAM10 5 GO:0051289 protein homotetramerization 5/502 57/18722 0.0181309080811164 0.0628737487130769 B2M/MCOLN1/SAMHD1/SOD2/GLS 5 GO:0061756 leukocyte adhesion to vascular endothelial cell 5/502 57/18722 0.0181309080811164 0.0628737487130769 ITGB2/ICAM1/ALOX5/SELPLG/KLF4 5 GO:0008306 associative learning 6/502 78/18722 0.0182531006073537 0.0632500699697516 LGMN/FOS/BTG2/ACTR2/PPT1/HIF1A 6 GO:0001825 blastocyst formation 4/502 38/18722 0.0183496782313232 0.0633474712672398 JUNB/RTN4/CITED2/SKIL 4 GO:0032373 positive regulation of sterol transport 4/502 38/18722 0.0183496782313232 0.0633474712672398 PLTP/APOE/ABCA1/LRP1 4 GO:0032376 positive regulation of cholesterol transport 4/502 38/18722 0.0183496782313232 0.0633474712672398 PLTP/APOE/ABCA1/LRP1 4 GO:0098926 postsynaptic signal transduction 4/502 38/18722 0.0183496782313232 0.0633474712672398 JAK2/RGS10/STAT3/GNAI2 4 GO:1901186 positive regulation of ERBB signaling pathway 4/502 38/18722 0.0183496782313232 0.0633474712672398 CCDC88A/RBPJ/NCF1/RTN4 4 GO:0014074 response to purine-containing compound 9/502 148/18722 0.0184472250384141 0.0635893167121486 ZFP36L1/ITPR2/SLC8A1/FOS/DUSP1/FOSB/STAT1/AHR/JUN 9 GO:0043484 regulation of RNA splicing 9/502 148/18722 0.0184472250384141 0.0635893167121486 CELF2/HSPA1A/QKI/MBNL1/SETX/DDX17/DDX5/TMBIM6/PIK3R1 9 GO:0097237 cellular response to toxic substance 8/502 124/18722 0.0186169532653915 0.0641266014934484 APOE/CD36/ALDH1A1/ALOX5AP/SOD2/GPX1/MGST2/SESN1 8 GO:0008037 cell recognition 12/502 225/18722 0.0186543344192578 0.064207552844856 FOLR2/CD209/CD36/HAVCR2/PECAM1/NRP1/CLEC7A/CD81/EMB/MSN/RTN4/COLEC12 12 GO:0098869 cellular oxidant detoxification 7/502 101/18722 0.0189480949641458 0.0651701764343037 APOE/CD36/ALOX5AP/SOD2/GPX1/MGST2/SESN1 7 GO:0048639 positive regulation of developmental growth 10/502 174/18722 0.0191598554626357 0.0658495478232934 MEF2C/IGF1/RBPJ/NRP1/ITSN2/TGFBR2/CYFIP1/LRP1/MACF1/GOLGA4 10 GO:0060420 regulation of heart growth 6/502 79/18722 0.0193215599975553 0.0663560033769049 MEF2C/IGF1/RUNX1/RBPJ/TGFBR2/CITED2 6 GO:0001954 positive regulation of cell-matrix adhesion 5/502 58/18722 0.0194179402033967 0.0665881329732493 CD36/RIN2/NRP1/IQGAP1/PLEKHA2 5 GO:0043666 regulation of phosphoprotein phosphatase activity 5/502 58/18722 0.0194179402033967 0.0665881329732493 NCKAP1L/PTPRC/JAK2/GNAI2/CALM2 5 GO:0055007 cardiac muscle cell differentiation 8/502 125/18722 0.0194413657064949 0.0666190798209227 MEF2C/IGF1/RBPJ/ARRB2/MEF2A/SLC8A1/TGFB1/AKAP13 8 GO:0098657 import into cell 12/502 227/18722 0.0198414595222242 0.0679397422278381 FOLR2/SLC9A9/ATP1B1/CD36/IL10RA/SLC2A3/PRNP/SLC15A3/SLC8A1/ACTB/SLC11A2/SLC1A3 12 GO:0006672 ceramide metabolic process 7/502 102/18722 0.0198917881751674 0.0680113910556722 ASAH1/SGMS1/PLA2G15/ST8SIA4/SPTLC2/ACER3/HEXA 7 GO:0010522 regulation of calcium ion transport into cytosol 7/502 102/18722 0.0198917881751674 0.0680113910556722 CYBA/PRNP/SLC8A1/LYN/PTPN6/TMBIM6/CALM2 7 GO:0045622 regulation of T-helper cell differentiation 4/502 39/18722 0.0200254448253737 0.0683168936299254 HLA-DRA/HLA-DRB1/CD86/NFKBIZ 4 GO:0046326 positive regulation of glucose import 4/502 39/18722 0.0200254448253737 0.0683168936299254 IGF1/MEF2A/CREBL2/PIK3R1 4 GO:2000249 regulation of actin cytoskeleton reorganization 4/502 39/18722 0.0200254448253737 0.0683168936299254 CSF1R/NRP1/GMFG/ARHGDIB 4 GO:0006907 pinocytosis 3/502 22/18722 0.0202045754019773 0.0685237285993747 EHD4/PYCARD/PPT1 3 GO:0032700 negative regulation of interleukin-17 production 3/502 22/18722 0.0202045754019773 0.0685237285993747 NCKAP1L/TLR4/PRNP 3 GO:0045061 thymic T cell selection 3/502 22/18722 0.0202045754019773 0.0685237285993747 CD28/CD74/PTPRC 3 GO:0051412 response to corticosterone 3/502 22/18722 0.0202045754019773 0.0685237285993747 FOS/FOXO3/FOSB 3 GO:0060965 negative regulation of gene silencing by miRNA 3/502 22/18722 0.0202045754019773 0.0685237285993747 NEAT1/TGFB1/STAT3 3 GO:0071359 cellular response to dsRNA 3/502 22/18722 0.0202045754019773 0.0685237285993747 IFIT1/IFIH1/COLEC12 3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 3/502 22/18722 0.0202045754019773 0.0685237285993747 RBPJ/XBP1/HIF1A 3 GO:2000725 regulation of cardiac muscle cell differentiation 3/502 22/18722 0.0202045754019773 0.0685237285993747 MEF2C/ARRB2/TGFB1 3 GO:0048145 regulation of fibroblast proliferation 6/502 80/18722 0.0204318653449468 0.0692438161800176 IGF1/GAS6/PDGFC/CD74/FTH1/NUPR1 6 GO:0043535 regulation of blood vessel endothelial cell migration 9/502 151/18722 0.0207258803412281 0.0701888158554329 MEF2C/SPRED1/TMSB4X/APOE/NRP1/KLF4/TGFB1/HIF1A/PRCP 9 GO:0030042 actin filament depolymerization 5/502 59/18722 0.0207634972361445 0.0702134051274886 PLEK/CAPG/CAPZA2/EPS8/GSN 5 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 5/502 59/18722 0.0207634972361445 0.0702134051274886 SAMSN1/PTPRC/PARP14/SNX6/PTPN6 5 GO:0003279 cardiac septum development 7/502 103/18722 0.0208678068064981 0.0704631199174161 PLXND1/RBPJ/NRP1/TGFBR2/ENG/DHRS3/CITED2 7 GO:0090277 positive regulation of peptide hormone secretion 7/502 103/18722 0.0208678068064981 0.0704631199174161 HLA-DRB1/ITSN1/JAK2/GLUL/HIF1A/LRP1/RAB8B 7 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/502 256/18722 0.0211550062870401 0.071380787077934 ZEB2/SPRED1/DAB2/RBPJ/HSPA1A/JAK2/SDCBP/ENG/SNX6/TGFB1/LRP1/CITED2/SKIL 13 GO:0015850 organic hydroxy compound transport 14/502 284/18722 0.0215508772697363 0.0726635264211373 SPP1/PLTP/SLCO2B1/APOE/CD36/MSR1/NPC2/SYK/ABCA1/ACTB/EMB/TSPO/LRP1/STX12 14 GO:0048144 fibroblast proliferation 6/502 81/18722 0.0215846801836275 0.0726715651597239 IGF1/GAS6/PDGFC/CD74/FTH1/NUPR1 6 GO:0051149 positive regulation of muscle cell differentiation 6/502 81/18722 0.0215846801836275 0.0726715651597239 MEF2C/IGF1/ARRB2/SOD2/ENG/TGFB1 6 GO:0002714 positive regulation of B cell mediated immunity 4/502 40/18722 0.021792468330104 0.0731051185605954 CD28/PTPRC/HLA-E/TGFB1 4 GO:0002891 positive regulation of immunoglobulin mediated immune response 4/502 40/18722 0.021792468330104 0.0731051185605954 CD28/PTPRC/HLA-E/TGFB1 4 GO:0071276 cellular response to cadmium ion 4/502 40/18722 0.021792468330104 0.0731051185605954 CYBB/FOS/NCF1/JUN 4 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 4/502 40/18722 0.021792468330104 0.0731051185605954 ITGB2/ICAM1/ALOX5/KLF4 4 GO:2000781 positive regulation of double-strand break repair 4/502 40/18722 0.021792468330104 0.0731051185605954 PARP9/ACTR2/DTX3L/WAS 4 GO:0006892 post-Golgi vesicle-mediated transport 7/502 104/18722 0.0218766444988711 0.0732812146645747 LAPTM5/MYO5A/VPS13C/EPS15/LAMP1/MACF1/GOLGA4 7 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 7/502 104/18722 0.0218766444988711 0.0732812146645747 LPAR6/C3AR1/CMKLR1/FPR3/C5AR1/FPR1/GPR65 7 GO:0006109 regulation of carbohydrate metabolic process 10/502 178/18722 0.0220459308419977 0.0737414866775715 IGF1/IGFBP4/PLEK/CLTC/PDK4/TGFB1/NUPR1/STAT3/HIF1A/RANBP2 10 GO:0035265 organ growth 10/502 178/18722 0.0220459308419977 0.0737414866775715 MEF2C/IGF1/RUNX1/PSAP/RBPJ/TGFBR2/CITED2/PRKAR1A/STK4/AKAP13 10 GO:0035303 regulation of dephosphorylation 8/502 128/18722 0.0220703930612784 0.0737699698710073 MEF2C/PLEK/NCKAP1L/PTPRC/JAK2/TGFB1/GNAI2/CALM2 8 GO:0031638 zymogen activation 5/502 60/18722 0.0221684744680587 0.0739908823154688 RUNX1/LGMN/CTSZ/IFI16/PYCARD 5 GO:0051851 modulation by host of symbiont process 5/502 60/18722 0.0221684744680587 0.0739908823154688 CCL3/APOE/IFI27/CCL4/JUN 5 GO:0001892 embryonic placenta development 6/502 82/18722 0.0227806459559323 0.0756050848966344 ZFP36L1/RBPJ/JUNB/HIF1A/CITED2/STK4 6 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3/502 23/18722 0.0227828552412253 0.0756050848966344 CTSZ/CYBA/ATP6AP2 3 GO:0006622 protein targeting to lysosome 3/502 23/18722 0.0227828552412253 0.0756050848966344 LAPTM5/LAMP2/NCOA4 3 GO:0035162 embryonic hemopoiesis 3/502 23/18722 0.0227828552412253 0.0756050848966344 TGFBR2/HIF1A/STK4 3 GO:0035994 response to muscle stretch 3/502 23/18722 0.0227828552412253 0.0756050848966344 SLC8A1/FOS/GSN 3 GO:0050765 negative regulation of phagocytosis 3/502 23/18722 0.0227828552412253 0.0756050848966344 FCGR2B/SIRPA/PLSCR1 3 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 3/502 23/18722 0.0227828552412253 0.0756050848966344 TYROBP/CD53/ADAM9 3 GO:2000737 negative regulation of stem cell differentiation 3/502 23/18722 0.0227828552412253 0.0756050848966344 ZFP36L2/N4BP2L2/STAT3 3 GO:0006605 protein targeting 15/502 314/18722 0.0228246609923186 0.075689520968076 LAPTM5/ITGB2/MAN1A1/ITGAM/PRNP/VPS13C/SDCBP/TSPO/NCF1/LAMP2/NCOA4/BNIP3L/TRAM1/HERPUD1/RAB8B 15 GO:0006022 aminoglycan metabolic process 8/502 129/18722 0.0229999372027252 0.0761615672869052 LYVE1/CLTC/CD44/TGFB1/GNS/DSE/FUCA1/HEXA 8 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 8/502 129/18722 0.0229999372027252 0.0761615672869052 LAPTM5/LGALS9/SYK/CTSD/CLEC7A/JAK2/PYCARD/GSN 8 GO:0017038 protein import 11/502 206/18722 0.0235000929311325 0.0777621100854212 APOE/CD36/TXNIP/SYK/JAK2/TGFB1/LAMP2/STAT3/RANBP2/PIK3R1/RAB8B 11 GO:0071384 cellular response to corticosteroid stimulus 5/502 61/18722 0.0236337177097333 0.0779853318153661 ICAM1/ZFP36L1/ZFP36/ZFP36L2/FOXO3 5 GO:0050691 regulation of defense response to virus by host 4/502 41/18722 0.023651841880017 0.0779853318153661 PARP9/PYCARD/DTX3L/STAT1 4 GO:0051693 actin filament capping 4/502 41/18722 0.023651841880017 0.0779853318153661 CAPG/CAPZA2/EPS8/GSN 4 GO:0071634 regulation of transforming growth factor beta production 4/502 41/18722 0.023651841880017 0.0779853318153661 TYROBP/LGALS9/ATP6AP2/HIF1A 4 GO:1902622 regulation of neutrophil migration 4/502 41/18722 0.023651841880017 0.0779853318153661 C3AR1/CD74/NCKAP1L/C5AR1 4 GO:0002062 chondrocyte differentiation 7/502 106/18722 0.0239946939840548 0.0788908701991737 MAF/MEF2C/RUNX1/TGFBI/TRPS1/TGFBR2/TGFB1 7 GO:0002793 positive regulation of peptide secretion 7/502 106/18722 0.0239946939840548 0.0788908701991737 HLA-DRB1/ITSN1/JAK2/GLUL/HIF1A/LRP1/RAB8B 7 GO:0046620 regulation of organ growth 7/502 106/18722 0.0239946939840548 0.0788908701991737 MEF2C/IGF1/RUNX1/RBPJ/TGFBR2/CITED2/STK4 7 GO:0071887 leukocyte apoptotic process 7/502 106/18722 0.0239946939840548 0.0788908701991737 MEF2C/GAS6/CD74/LGALS9/LYN/TSC22D3/HIF1A 7 GO:0031397 negative regulation of protein ubiquitination 6/502 83/18722 0.0240203813690651 0.0789192359469426 ARRB2/HSPA1A/ISG15/DTX3L/TSPO/IVNS1ABP 6 GO:0060560 developmental growth involved in morphogenesis 12/502 234/18722 0.0244422603981059 0.0802483297385649 SPP1/APOE/ARHGAP4/NRP1/ITSN2/IQGAP1/TGFBR2/CYFIP1/RTN4/LRP1/MACF1/GOLGA4 12 GO:0035051 cardiocyte differentiation 9/502 156/18722 0.0249635482995687 0.0819016839956062 MEF2C/IGF1/RBPJ/ARRB2/MEF2A/SLC8A1/TGFB1/CITED2/AKAP13 9 GO:0032835 glomerulus development 5/502 62/18722 0.0251600225680205 0.0823710292991244 MEF2C/MTSS1/PECAM1/EGR1/IQGAP1 5 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 5/502 62/18722 0.0251600225680205 0.0823710292991244 DAB2/SDCBP/ENG/TGFB1/LRP1 5 GO:1902750 negative regulation of cell cycle G2/M phase transition 5/502 62/18722 0.0251600225680205 0.0823710292991244 ATM/NABP1/TAOK3/ATF5/TAOK1 5 GO:0002088 lens development in camera-type eye 6/502 84/18722 0.0253044817918339 0.0826101148687534 MAF/SPRED1/TGFBR2/VIM/CITED2/SKIL 6 GO:0010660 regulation of muscle cell apoptotic process 6/502 84/18722 0.0253044817918339 0.0826101148687534 IGF1/ARRB2/JAK2/SOD2/NUPR1/STK4 6 GO:0097061 dendritic spine organization 6/502 84/18722 0.0253044817918339 0.0826101148687534 FCGR2B/LGMN/APOE/PRNP/ACTR2/ADAM10 6 GO:1900542 regulation of purine nucleotide metabolic process 6/502 84/18722 0.0253044817918339 0.0826101148687534 IGF1/TMSB4X/PDK4/NUPR1/STAT3/HIF1A 6 GO:0002438 acute inflammatory response to antigenic stimulus 3/502 24/18722 0.0255313290346017 0.0827140671757692 FCGR2B/ICAM1/HLA-E 3 GO:0002922 positive regulation of humoral immune response 3/502 24/18722 0.0255313290346017 0.0827140671757692 CR1/FCGR2B/PTPRC 3 GO:0003148 outflow tract septum morphogenesis 3/502 24/18722 0.0255313290346017 0.0827140671757692 NRP1/TGFBR2/ENG 3 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 3/502 24/18722 0.0255313290346017 0.0827140671757692 RBPJ/KLF2/HIF1A 3 GO:0036010 protein localization to endosome 3/502 24/18722 0.0255313290346017 0.0827140671757692 NRP1/DTX3L/MSN 3 GO:0045649 regulation of macrophage differentiation 3/502 24/18722 0.0255313290346017 0.0827140671757692 C1QC/RB1/TGFB1 3 GO:0060561 apoptotic process involved in morphogenesis 3/502 24/18722 0.0255313290346017 0.0827140671757692 TNFRSF1B/SPI1/TNFRSF1A 3 GO:1903077 negative regulation of protein localization to plasma membrane 3/502 24/18722 0.0255313290346017 0.0827140671757692 DAB2/CLTC/TGFB1 3 GO:2000310 regulation of NMDA receptor activity 3/502 24/18722 0.0255313290346017 0.0827140671757692 MEF2C/CCL2/IFNGR2 3 GO:0006040 amino sugar metabolic process 4/502 42/18722 0.0256045274958282 0.0827140671757692 ALDH1A1/NPL/MGAT1/GNPDA1 4 GO:0010591 regulation of lamellipodium assembly 4/502 42/18722 0.0256045274958282 0.0827140671757692 ACTR2/CYFIP1/WAS/PIK3R1 4 GO:0014912 negative regulation of smooth muscle cell migration 4/502 42/18722 0.0256045274958282 0.0827140671757692 MEF2C/AIF1/LRP1/GNA13 4 GO:0030574 collagen catabolic process 4/502 42/18722 0.0256045274958282 0.0827140671757692 CTSS/CTSB/CST3/PEPD 4 GO:0042168 heme metabolic process 4/502 42/18722 0.0256045274958282 0.0827140671757692 SLCO2B1/BLVRB/SLC11A2/TSPO 4 GO:2000404 regulation of T cell migration 4/502 42/18722 0.0256045274958282 0.0827140671757692 AIF1/TNFRSF14/PYCARD/ADAM10 4 GO:0003018 vascular process in circulatory system 13/502 263/18722 0.0256673772753893 0.0828592374570488 SLCO2B1/APOE/CD36/ICAM1/TBXAS1/KLF2/SLC2A3/SLC8A1/SOD2/GPX1/TGFB1/SLC1A3/LRP1 13 GO:1904951 positive regulation of establishment of protein localization 15/502 319/18722 0.0258114373914443 0.0832661850577555 IGF1/GAS6/ITGB2/TLR4/ITGAM/HLA-DRB1/ADAM9/PRNP/CD81/JAK2/GLUL/TGFB1/HIF1A/LRP1/PIK3R1 15 GO:0015833 peptide transport 13/502 264/18722 0.0263657301040531 0.0849950295897907 CD209/CD74/HLA-DRB1/ITSN1/ABCA1/ALOX5/SLC15A3/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 13 GO:0001947 heart looping 5/502 63/18722 0.0267481338319692 0.0861077711250449 MEF2C/TGFBR2/ENG/HIF1A/CITED2 5 GO:0032233 positive regulation of actin filament bundle assembly 5/502 63/18722 0.0267481338319692 0.0861077711250449 PLEK/MTSS1/CCDC88A/NRP1/GPR65 5 GO:0010595 positive regulation of endothelial cell migration 8/502 133/18722 0.0269938914386858 0.0867781388431971 LGMN/TMSB4X/RIN2/GRN/NRP1/TGFB1/HIF1A/RHOB 8 GO:0046887 positive regulation of hormone secretion 8/502 133/18722 0.0269938914386858 0.0867781388431971 SPP1/HLA-DRB1/ITSN1/JAK2/GLUL/HIF1A/LRP1/RAB8B 8 GO:0050807 regulation of synapse organization 11/502 211/18722 0.0273980640946707 0.0880162809041297 MEF2C/FCGR2B/APOE/SRGN/ITSN1/IL10RA/PRNP/TUBA1A/ACTR2/CYFIP1/ADAM10 11 GO:0032414 positive regulation of ion transmembrane transporter activity 7/502 109/18722 0.0274295717764461 0.0880563490894098 CCL2/ATP1B1/TMSB4X/CTSS/VMP1/IFNGR2/CALM2 7 GO:0009268 response to pH 4/502 43/18722 0.0276513575820311 0.0881395843021401 LGMN/CTSS/MCOLN1/GPR65 4 GO:0045981 positive regulation of nucleotide metabolic process 4/502 43/18722 0.0276513575820311 0.0881395843021401 IGF1/TMSB4X/STAT3/HIF1A 4 GO:0071604 transforming growth factor beta production 4/502 43/18722 0.0276513575820311 0.0881395843021401 TYROBP/LGALS9/ATP6AP2/HIF1A 4 GO:1900544 positive regulation of purine nucleotide metabolic process 4/502 43/18722 0.0276513575820311 0.0881395843021401 IGF1/TMSB4X/STAT3/HIF1A 4 GO:0051896 regulation of protein kinase B signaling 10/502 185/18722 0.0278358997236336 0.0881395843021401 GAS6/CD28/CCL3/ARRB2/MTDH/GPX1/ENG/KLF4/TGFB1/RTN4 10 GO:0010948 negative regulation of cell cycle process 14/502 294/18722 0.0278926613800196 0.0881395843021401 CCL2/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/NABP1/TAOK3/FEM1B/ATF5/TAOK1/PRKAR1A 14 GO:0002002 regulation of angiotensin levels in blood 2/502 10/18722 0.0279991221690536 0.0881395843021401 CTSZ/ATP6AP2 2 GO:0002003 angiotensin maturation 2/502 10/18722 0.0279991221690536 0.0881395843021401 CTSZ/ATP6AP2 2 GO:0002524 hypersensitivity 2/502 10/18722 0.0279991221690536 0.0881395843021401 FCGR2B/HLA-E 2 GO:0003330 regulation of extracellular matrix constituent secretion 2/502 10/18722 0.0279991221690536 0.0881395843021401 TNFRSF1B/TNFRSF1A 2 GO:0006646 phosphatidylethanolamine biosynthetic process 2/502 10/18722 0.0279991221690536 0.0881395843021401 ETNK1/CEPT1 2 GO:0010728 regulation of hydrogen peroxide biosynthetic process 2/502 10/18722 0.0279991221690536 0.0881395843021401 SOD2/STAT3 2 GO:0030214 hyaluronan catabolic process 2/502 10/18722 0.0279991221690536 0.0881395843021401 CD44/TGFB1 2 GO:0033572 transferrin transport 2/502 10/18722 0.0279991221690536 0.0881395843021401 MCOLN1/CLTC 2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 2/502 10/18722 0.0279991221690536 0.0881395843021401 PARP9/NAMPT 2 GO:0035376 sterol import 2/502 10/18722 0.0279991221690536 0.0881395843021401 CD36/LRP1 2 GO:0035907 dorsal aorta development 2/502 10/18722 0.0279991221690536 0.0881395843021401 RBPJ/ENG 2 GO:0042989 sequestering of actin monomers 2/502 10/18722 0.0279991221690536 0.0881395843021401 TMSB4X/GSN 2 GO:0050861 positive regulation of B cell receptor signaling pathway 2/502 10/18722 0.0279991221690536 0.0881395843021401 CD81/CMTM3 2 GO:0070508 cholesterol import 2/502 10/18722 0.0279991221690536 0.0881395843021401 CD36/LRP1 2 GO:0071803 positive regulation of podosome assembly 2/502 10/18722 0.0279991221690536 0.0881395843021401 LCP1/MSN 2 GO:0072203 cell proliferation involved in metanephros development 2/502 10/18722 0.0279991221690536 0.0881395843021401 EGR1/STAT1 2 GO:0098885 modification of postsynaptic actin cytoskeleton 2/502 10/18722 0.0279991221690536 0.0881395843021401 ITSN1/CYFIP1 2 GO:0099532 synaptic vesicle endosomal processing 2/502 10/18722 0.0279991221690536 0.0881395843021401 ITSN1/ITSN2 2 GO:1903980 positive regulation of microglial cell activation 2/502 10/18722 0.0279991221690536 0.0881395843021401 CCL3/CTSC 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/502 10/18722 0.0279991221690536 0.0881395843021401 CD81/LRP1 2 GO:2000425 regulation of apoptotic cell clearance 2/502 10/18722 0.0279991221690536 0.0881395843021401 C2/CCL2 2 GO:0006140 regulation of nucleotide metabolic process 6/502 86/18722 0.028008039110278 0.0881395843021401 IGF1/TMSB4X/PDK4/NUPR1/STAT3/HIF1A 6 GO:0045921 positive regulation of exocytosis 6/502 86/18722 0.028008039110278 0.0881395843021401 ITGB2/ITGAM/SYK/SDCBP/LAMP1/ATP6AP1 6 GO:0001885 endothelial cell development 5/502 64/18722 0.0283987449669399 0.0886249593263866 ICAM1/PECAM1/GPX1/TNFRSF1A/MSN 5 GO:0030837 negative regulation of actin filament polymerization 5/502 64/18722 0.0283987449669399 0.0886249593263866 TMSB4X/CAPG/CAPZA2/EPS8/GSN 5 GO:0070542 response to fatty acid 5/502 64/18722 0.0283987449669399 0.0886249593263866 CD36/TBXAS1/PDK4/UCP2/FOXO3 5 GO:0006658 phosphatidylserine metabolic process 3/502 25/18722 0.0284496464763692 0.0886249593263866 PLA2G15/PLSCR1/SERINC1 3 GO:0010447 response to acidic pH 3/502 25/18722 0.0284496464763692 0.0886249593263866 LGMN/CTSS/GPR65 3 GO:0031579 membrane raft organization 3/502 25/18722 0.0284496464763692 0.0886249593263866 PTPRC/PPT1/GSN 3 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 3/502 25/18722 0.0284496464763692 0.0886249593263866 LY96/CD36/LY86 3 GO:0033622 integrin activation 3/502 25/18722 0.0284496464763692 0.0886249593263866 PLEK/PTGER4/FERMT3 3 GO:0051450 myoblast proliferation 3/502 25/18722 0.0284496464763692 0.0886249593263866 IGF1/MALAT1/GPX1 3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3/502 25/18722 0.0284496464763692 0.0886249593263866 TLR4/HSPA1A/SLC15A3 3 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 3/502 25/18722 0.0284496464763692 0.0886249593263866 ATP1B1/SLC8A1/CALM2 3 GO:0090330 regulation of platelet aggregation 3/502 25/18722 0.0284496464763692 0.0886249593263866 SYK/LYN/JAK2 3 GO:1901798 positive regulation of signal transduction by p53 class mediator 3/502 25/18722 0.0284496464763692 0.0886249593263866 SPRED1/ATM/DDX5 3 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 3/502 25/18722 0.0284496464763692 0.0886249593263866 TGFB1/STAT3/DDX5 3 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 3/502 25/18722 0.0284496464763692 0.0886249593263866 ITGB2/ICAM1/ALOX5 3 GO:0003014 renal system process 7/502 110/18722 0.0286450204452996 0.0891135605783161 GAS6/LGMN/CYBA/SGK1/PRKACB/GNAI2/GSN 7 GO:1905954 positive regulation of lipid localization 7/502 110/18722 0.0286450204452996 0.0891135605783161 SPP1/PLTP/APOE/CD36/MSR1/ABCA1/LRP1 7 GO:0042157 lipoprotein metabolic process 8/502 135/18722 0.0291612071742066 0.0906584303681989 APOE/ABCA1/CTSD/APOL6/ATG7/GLUL/PPT1/LRP1 8 GO:0050708 regulation of protein secretion 13/502 268/18722 0.0292993023113291 0.0910265765562179 IGF1/APOE/TLR4/HLA-DRB1/RSAD2/ADAM9/ALOX5/JAK2/GLUL/UCP2/TGFB1/HIF1A/LRP1 13 GO:0048041 focal adhesion assembly 6/502 87/18722 0.0294285651823353 0.0911221837573515 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1 6 GO:0150104 transport across blood-brain barrier 6/502 87/18722 0.0294285651823353 0.0911221837573515 SLCO2B1/APOE/CD36/SLC2A3/SLC1A3/LRP1 6 GO:1901879 regulation of protein depolymerization 6/502 87/18722 0.0294285651823353 0.0911221837573515 PLEK/CAPG/CAPZA2/EPS8/GSN/TAOK1 6 GO:1903578 regulation of ATP metabolic process 6/502 87/18722 0.0294285651823353 0.0911221837573515 IGF1/TMSB4X/TSPO/NUPR1/STAT3/HIF1A 6 GO:2000177 regulation of neural precursor cell proliferation 6/502 87/18722 0.0294285651823353 0.0911221837573515 CTSZ/LYN/BTG2/FOXO3/GNAI2/HIF1A 6 GO:0032620 interleukin-17 production 4/502 44/18722 0.0297930366939776 0.0920043976944863 NCKAP1L/TLR4/PRNP/TGFB1 4 GO:0032660 regulation of interleukin-17 production 4/502 44/18722 0.0297930366939776 0.0920043976944863 NCKAP1L/TLR4/PRNP/TGFB1 4 GO:0048066 developmental pigmentation 4/502 44/18722 0.0297930366939776 0.0920043976944863 MEF2C/ZEB2/CD63/ATP6AP2 4 GO:0097178 ruffle assembly 4/502 44/18722 0.0297930366939776 0.0920043976944863 AIF1/ICAM1/CYFIP1/EPS8 4 GO:0070613 regulation of protein processing 5/502 65/18722 0.0301124977134123 0.0929288955451938 RUNX1/CTSZ/PRNP/PRKACB/GSN 5 GO:0003158 endothelium development 8/502 136/18722 0.0302886123466776 0.0934100804771536 ICAM1/RBPJ/PECAM1/NRP1/GPX1/TNFRSF1A/MSN/RHOB 8 GO:0051494 negative regulation of cytoskeleton organization 9/502 162/18722 0.0308195128478363 0.0949654594064335 TMSB4X/GMFG/WAS/CAPG/CAPZA2/EPS8/PIK3R1/GSN/TAOK1 9 GO:0010232 vascular transport 6/502 88/18722 0.0308955936892958 0.0949654594064335 SLCO2B1/APOE/CD36/SLC2A3/SLC1A3/LRP1 6 GO:0030101 natural killer cell activation 6/502 88/18722 0.0308955936892958 0.0949654594064335 GAS6/TYROBP/PTPRC/HAVCR2/HLA-E/LAMP1 6 GO:0050829 defense response to Gram-negative bacterium 6/502 88/18722 0.0308955936892958 0.0949654594064335 CD4/MPEG1/RNASE6/TLR4/TNFRSF14/PYCARD 6 GO:0070098 chemokine-mediated signaling pathway 6/502 88/18722 0.0308955936892958 0.0949654594064335 CCL2/CMKLR1/CCL3/CCR1/CCL4/HIF1A 6 GO:1901990 regulation of mitotic cell cycle phase transition 14/502 299/18722 0.0315354693192588 0.0963609599040058 CCL2/AIF1/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/NABP1/PTPN6/TAOK3/TAOK1/KMT2E 14 GO:0002092 positive regulation of receptor internalization 3/502 26/18722 0.0315370716157944 0.0963609599040058 SYK/ARRB2/CD63 3 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 3/502 26/18722 0.0315370716157944 0.0963609599040058 TLR4/HSPA1A/SLC15A3 3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 3/502 26/18722 0.0315370716157944 0.0963609599040058 PTPRC/CD81/CMTM3 3 GO:0070102 interleukin-6-mediated signaling pathway 3/502 26/18722 0.0315370716157944 0.0963609599040058 SPI1/JAK2/STAT3 3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 3/502 26/18722 0.0315370716157944 0.0963609599040058 TGFB1/STAT3/DDX5 3 GO:0097066 response to thyroid hormone 3/502 26/18722 0.0315370716157944 0.0963609599040058 CTSS/CTSB/CAB39 3 GO:1904376 negative regulation of protein localization to cell periphery 3/502 26/18722 0.0315370716157944 0.0963609599040058 DAB2/CLTC/TGFB1 3 GO:2000108 positive regulation of leukocyte apoptotic process 3/502 26/18722 0.0315370716157944 0.0963609599040058 MEF2C/LGALS9/LYN 3 GO:0010976 positive regulation of neuron projection development 9/502 163/18722 0.0318810881374895 0.0972465759698982 APOE/GRN/LYN/IQGAP1/ACTR2/CYFIP1/SETX/LRP1/PLXNB2 9 GO:0050922 negative regulation of chemotaxis 5/502 66/18722 0.0318899817869294 0.0972465759698982 CCL2/AIF1/NRP1/DUSP1/DUSP3 5 GO:0071300 cellular response to retinoic acid 5/502 66/18722 0.0318899817869294 0.0972465759698982 ABCA1/LYN/ATM/KLF4/SETX 5 GO:0003197 endocardial cushion development 4/502 45/18722 0.0320301435488248 0.0972931694547097 RBPJ/TGFBR2/ENG/CITED2 4 GO:0006110 regulation of glycolytic process 4/502 45/18722 0.0320301435488248 0.0972931694547097 IGF1/NUPR1/STAT3/HIF1A 4 GO:0030835 negative regulation of actin filament depolymerization 4/502 45/18722 0.0320301435488248 0.0972931694547097 CAPG/CAPZA2/EPS8/GSN 4 GO:0031670 cellular response to nutrient 4/502 45/18722 0.0320301435488248 0.0972931694547097 FOLR2/GAS6/XBP1/USF2 4 GO:0035307 positive regulation of protein dephosphorylation 4/502 45/18722 0.0320301435488248 0.0972931694547097 PTPRC/JAK2/TGFB1/CALM2 4 GO:1904062 regulation of cation transmembrane transport 16/502 357/18722 0.0320314520275665 0.0972931694547097 MEF2C/CCL2/ATP1B1/TMSB4X/CTSS/CYBA/VMP1/PRNP/SLC8A1/LYN/CD63/IFNGR2/FXYD5/PTPN6/CAB39/CALM2 16 GO:0010657 muscle cell apoptotic process 6/502 89/18722 0.0324095956556548 0.0983771584665743 IGF1/ARRB2/JAK2/SOD2/NUPR1/STK4 6 GO:0044344 cellular response to fibroblast growth factor stimulus 7/502 113/18722 0.0325085041486833 0.0986126820929893 CCL2/ZFP36L1/ZFP36/ZFP36L2/CD44/NR4A1/SETX 7 GO:0051216 cartilage development 10/502 190/18722 0.0325852320389291 0.0987806575439619 MAF/MEF2C/RUNX1/TGFBI/TRPS1/TGFBR2/CD44/TGFB1/TIMP1/HIF1A 10 GO:0055076 transition metal ion homeostasis 8/502 138/18722 0.0326324838064988 0.0988591159717507 FTL/B2M/PRNP/FTH1/SLC11A2/NCOA4/HIF1A/ATP6AP1 8 GO:0042063 gliogenesis 14/502 301/18722 0.0330856044999616 0.099832507101225 C1QA/CCL2/CCL3/TLR4/TNFRSF1B/C5AR1/GRN/LYN/VIM/TSPO/TGFB1/STAT3/RTN4/LRP1 14 GO:0009306 protein secretion 16/502 359/18722 0.0334555789107835 0.099832507101225 IGF1/APOE/PLEK/TLR4/HLA-DRB1/RSAD2/ADAM9/ABCA1/ALOX5/JAK2/GLUL/UCP2/TGFB1/HIF1A/LRP1/RAB8B 16 GO:0001867 complement activation, lectin pathway 2/502 11/18722 0.0336227942204299 0.099832507101225 A2M/SERPING1 2 GO:0002327 immature B cell differentiation 2/502 11/18722 0.0336227942204299 0.099832507101225 SPI1/ATM 2 GO:0003093 regulation of glomerular filtration 2/502 11/18722 0.0336227942204299 0.099832507101225 GAS6/CYBA 2 GO:0003139 secondary heart field specification 2/502 11/18722 0.0336227942204299 0.099832507101225 MEF2C/RBPJ 2 GO:0003157 endocardium development 2/502 11/18722 0.0336227942204299 0.099832507101225 RBPJ/STK4 2 GO:0006054 N-acetylneuraminate metabolic process 2/502 11/18722 0.0336227942204299 0.099832507101225 NPL/GNPDA1 2 GO:0006971 hypotonic response 2/502 11/18722 0.0336227942204299 0.099832507101225 TSPO/CAB39 2 GO:0010269 response to selenium ion 2/502 11/18722 0.0336227942204299 0.099832507101225 SOD2/GPX1 2 GO:0019048 modulation by virus of host process 2/502 11/18722 0.0336227942204299 0.099832507101225 CD4/ATG7 2 GO:0032493 response to bacterial lipoprotein 2/502 11/18722 0.0336227942204299 0.099832507101225 CD14/CD36 2 GO:0033483 gas homeostasis 2/502 11/18722 0.0336227942204299 0.099832507101225 SOD2/HIF1A 2 GO:0033860 regulation of NAD(P)H oxidase activity 2/502 11/18722 0.0336227942204299 0.099832507101225 CYBA/GNAI2 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/502 11/18722 0.0336227942204299 0.099832507101225 RSAD2/RTN4 2 GO:0034350 regulation of glial cell apoptotic process 2/502 11/18722 0.0336227942204299 0.099832507101225 CCL2/GAS6 2 GO:0042167 heme catabolic process 2/502 11/18722 0.0336227942204299 0.099832507101225 SLCO2B1/BLVRB 2 GO:0042789 mRNA transcription by RNA polymerase II 2/502 11/18722 0.0336227942204299 0.099832507101225 C5AR1/STAT3 2 GO:0044068 modulation by symbiont of host cellular process 2/502 11/18722 0.0336227942204299 0.099832507101225 CD4/ATG7 2 GO:0046149 pigment catabolic process 2/502 11/18722 0.0336227942204299 0.099832507101225 SLCO2B1/BLVRB 2 GO:0048680 positive regulation of axon regeneration 2/502 11/18722 0.0336227942204299 0.099832507101225 GRN/LRP1 2 GO:0060312 regulation of blood vessel remodeling 2/502 11/18722 0.0336227942204299 0.099832507101225 CST3/TGFB1 2 GO:0060742 epithelial cell differentiation involved in prostate gland development 2/502 11/18722 0.0336227942204299 0.099832507101225 PSAP/FEM1B 2 GO:0060837 blood vessel endothelial cell differentiation 2/502 11/18722 0.0336227942204299 0.099832507101225 RBPJ/NRP1 2 GO:0075733 intracellular transport of virus 2/502 11/18722 0.0336227942204299 0.099832507101225 CD209/BST2 2 GO:0090160 Golgi to lysosome transport 2/502 11/18722 0.0336227942204299 0.099832507101225 LAPTM5/LAMP1 2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 2/502 11/18722 0.0336227942204299 0.099832507101225 CD36/TLR4 2 GO:1902337 regulation of apoptotic process involved in morphogenesis 2/502 11/18722 0.0336227942204299 0.099832507101225 TNFRSF1B/TNFRSF1A 2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 2/502 11/18722 0.0336227942204299 0.099832507101225 LAPTM5/HSPA1A 2 GO:1905668 positive regulation of protein localization to endosome 2/502 11/18722 0.0336227942204299 0.099832507101225 DTX3L/MSN 2 GO:2000392 regulation of lamellipodium morphogenesis 2/502 11/18722 0.0336227942204299 0.099832507101225 ENPP2/CD44 2 GO:0010517 regulation of phospholipase activity 5/502 67/18722 0.0337317346755667 0.0998355755656886 CD86/C5AR1/PPT1/LRP1/GNA13 5 GO:0050435 amyloid-beta metabolic process 5/502 67/18722 0.0337317346755667 0.0998355755656886 IGF1/APOE/PRNP/RTN4/ADAM10 5 GO:0061180 mammary gland epithelium development 5/502 67/18722 0.0337317346755667 0.0998355755656886 CSF1R/JAK2/GPX1/HIF1A/RTN4 5 GO:0061371 determination of heart left/right asymmetry 5/502 67/18722 0.0337317346755667 0.0998355755656886 MEF2C/TGFBR2/ENG/HIF1A/CITED2 5 GO:1903317 regulation of protein maturation 5/502 67/18722 0.0337317346755667 0.0998355755656886 RUNX1/CTSZ/PRNP/PRKACB/GSN 5 GO:0035304 regulation of protein dephosphorylation 6/502 90/18722 0.0339710159826751 0.100415284304061 NCKAP1L/PTPRC/JAK2/TGFB1/GNAI2/CALM2 6 GO:0099175 regulation of postsynapse organization 6/502 90/18722 0.0339710159826751 0.100415284304061 FCGR2B/APOE/SRGN/PRNP/ACTR2/ADAM10 6 GO:0003007 heart morphogenesis 12/502 246/18722 0.0340799254159551 0.100672883125293 MEF2C/PLXND1/RBPJ/NRP1/TGFBR2/ENG/TGFB1/DHRS3/HIF1A/RTN4/GAA/CITED2 12 GO:0035592 establishment of protein localization to extracellular region 16/502 360/18722 0.0341848048592481 0.100918256080971 IGF1/APOE/PLEK/TLR4/HLA-DRB1/RSAD2/ADAM9/ABCA1/ALOX5/JAK2/GLUL/UCP2/TGFB1/HIF1A/LRP1/RAB8B 16 GO:0001974 blood vessel remodeling 4/502 46/18722 0.0343631332562343 0.100993554284206 MEF2C/RBPJ/CST3/TGFB1 4 GO:0010828 positive regulation of glucose transmembrane transport 4/502 46/18722 0.0343631332562343 0.100993554284206 IGF1/MEF2A/CREBL2/PIK3R1 4 GO:0044818 mitotic G2/M transition checkpoint 4/502 46/18722 0.0343631332562343 0.100993554284206 ATM/NABP1/TAOK3/TAOK1 4 GO:0061028 establishment of endothelial barrier 4/502 46/18722 0.0343631332562343 0.100993554284206 ICAM1/PECAM1/TNFRSF1A/MSN 4 GO:0071827 plasma lipoprotein particle organization 4/502 46/18722 0.0343631332562343 0.100993554284206 PLTP/APOE/ABCA1/PRKACB 4 GO:1900271 regulation of long-term synaptic potentiation 4/502 46/18722 0.0343631332562343 0.100993554284206 TYROBP/LGMN/APOE/PRNP 4 GO:2000107 negative regulation of leukocyte apoptotic process 4/502 46/18722 0.0343631332562343 0.100993554284206 GAS6/CD74/TSC22D3/HIF1A 4 GO:0034764 positive regulation of transmembrane transport 11/502 219/18722 0.0345720846963938 0.101543151622551 CCL2/IGF1/ATP1B1/TMSB4X/CTSS/VMP1/MEF2A/IFNGR2/CREBL2/CALM2/PIK3R1 11 GO:0003272 endocardial cushion formation 3/502 27/18722 0.0347925111857896 0.101674135657273 RBPJ/TGFBR2/ENG 3 GO:0007263 nitric oxide mediated signal transduction 3/502 27/18722 0.0347925111857896 0.101674135657273 APOE/CD36/FPR1 3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/502 27/18722 0.0347925111857896 0.101674135657273 ATP1B1/SLC8A1/CALM2 3 GO:0034377 plasma lipoprotein particle assembly 3/502 27/18722 0.0347925111857896 0.101674135657273 APOE/ABCA1/PRKACB 3 GO:0045830 positive regulation of isotype switching 3/502 27/18722 0.0347925111857896 0.101674135657273 CD28/PTPRC/TGFB1 3 GO:0046337 phosphatidylethanolamine metabolic process 3/502 27/18722 0.0347925111857896 0.101674135657273 PLA2G15/ETNK1/CEPT1 3 GO:0061437 renal system vasculature development 3/502 27/18722 0.0347925111857896 0.101674135657273 PECAM1/NRP1/EGR1 3 GO:0061440 kidney vasculature development 3/502 27/18722 0.0347925111857896 0.101674135657273 PECAM1/NRP1/EGR1 3 GO:0043279 response to alkaloid 7/502 115/18722 0.0352688365261543 0.10293604906624 AIF1/ICAM1/SLC8A1/HNMT/ATG7/FOSB/SLC1A3 7 GO:0046916 cellular transition metal ion homeostasis 7/502 115/18722 0.0352688365261543 0.10293604906624 FTL/PRNP/FTH1/SLC11A2/NCOA4/HIF1A/ATP6AP1 7 GO:0090287 regulation of cellular response to growth factor stimulus 14/502 304/18722 0.0355134253072072 0.10358455578256 ZEB2/SPRED1/DAB2/RBPJ/HSPA1A/CD63/SDCBP/ENG/SNX6/CYFIP1/TGFB1/HIF1A/CITED2/SKIL 14 GO:0051492 regulation of stress fiber assembly 6/502 91/18722 0.0355802731206638 0.103687110266468 CCDC88A/PTGER4/NRP1/GPR65/WAS/PIK3R1 6 GO:0007585 respiratory gaseous exchange by respiratory system 5/502 68/18722 0.0356382415312763 0.103687110266468 MAFB/NR4A2/HNMT/GLS/GAA 5 GO:0009988 cell-cell recognition 5/502 68/18722 0.0356382415312763 0.103687110266468 FOLR2/CD209/HAVCR2/CD81/MSN 5 GO:0032922 circadian regulation of gene expression 5/502 68/18722 0.0356382415312763 0.103687110266468 NAMPT/EGR1/NRIP1/AHR/ZFHX3 5 GO:0021782 glial cell development 7/502 116/18722 0.036705446201787 0.106375852291112 C1QA/TLR4/C5AR1/GRN/LYN/VIM/LRP1 7 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 4/502 47/18722 0.0367923397461694 0.106375852291112 CTSZ/CYBA/SOD2/ATP6AP2 4 GO:0007595 lactation 4/502 47/18722 0.0367923397461694 0.106375852291112 OAS2/XBP1/HIF1A/USF2 4 GO:0010799 regulation of peptidyl-threonine phosphorylation 4/502 47/18722 0.0367923397461694 0.106375852291112 SPRED1/TGFB1/CAB39/CALM2 4 GO:0031641 regulation of myelination 4/502 47/18722 0.0367923397461694 0.106375852291112 CTSC/TNFRSF1B/TYMP/CYFIP1 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/502 47/18722 0.0367923397461694 0.106375852291112 MEF2C/MTSS1/IQGAP1/STAT1 4 GO:0042311 vasodilation 4/502 47/18722 0.0367923397461694 0.106375852291112 APOE/KLF2/SOD2/GPX1 4 GO:0046677 response to antibiotic 4/502 47/18722 0.0367923397461694 0.106375852291112 MEF2C/JAK2/ACTR2/SLC1A3 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/502 47/18722 0.0367923397461694 0.106375852291112 TLR4/ALDH1A1/RB1/RBPJ 4 GO:1900744 regulation of p38MAPK cascade 4/502 47/18722 0.0367923397461694 0.106375852291112 SPI1/DUSP1/GADD45B/NCF1 4 GO:0099173 postsynapse organization 9/502 168/18722 0.0375707817040696 0.108558673430997 FCGR2B/LGMN/APOE/SRGN/PRNP/NRP1/ACTB/ACTR2/ADAM10 9 GO:0003143 embryonic heart tube morphogenesis 5/502 69/18722 0.0376099351514282 0.108603970044012 MEF2C/TGFBR2/ENG/HIF1A/CITED2 5 GO:2000045 regulation of G1/S transition of mitotic cell cycle 8/502 142/18722 0.0376846780906122 0.108751915687568 CCL2/AIF1/GPNMB/RB1/ATM/KLF4/PTPN6/KMT2E 8 GO:0000303 response to superoxide 3/502 28/18722 0.0382145414981128 0.110006514605022 CD36/SOD2/UCP2 3 GO:0010818 T cell chemotaxis 3/502 28/18722 0.0382145414981128 0.110006514605022 CCL3/CXCL16/ADAM10 3 GO:1903649 regulation of cytoplasmic transport 3/502 28/18722 0.0382145414981128 0.110006514605022 DAB2/MSN/DNAJC13 3 GO:1990776 response to angiotensin 3/502 28/18722 0.0382145414981128 0.110006514605022 CYBB/CYBA/IQGAP1 3 GO:0003015 heart process 12/502 251/18722 0.0388029684385291 0.111630927858604 ATP1B1/TMIGD3/CELF2/MEF2A/SLC8A1/JAK2/GPX1/GNAI2/GAA/CALM2/GSN/AKAP13 12 GO:0106027 neuron projection organization 6/502 93/18722 0.0389438376739101 0.111897014335098 FCGR2B/LGMN/APOE/PRNP/ACTR2/ADAM10 6 GO:1901796 regulation of signal transduction by p53 class mediator 6/502 93/18722 0.0389438376739101 0.111897014335098 SPRED1/CD74/ATM/CD44/SGK1/DDX5 6 GO:0043303 mast cell degranulation 4/502 48/18722 0.0393179783725232 0.112028688628509 CD84/LGALS9/SYK/LYN 4 GO:0048146 positive regulation of fibroblast proliferation 4/502 48/18722 0.0393179783725232 0.112028688628509 IGF1/GAS6/PDGFC/CD74 4 GO:0090199 regulation of release of cytochrome c from mitochondria 4/502 48/18722 0.0393179783725232 0.112028688628509 IGF1/ARRB2/PYCARD/GPX1 4 GO:1902003 regulation of amyloid-beta formation 4/502 48/18722 0.0393179783725232 0.112028688628509 IGF1/APOE/PRNP/RTN4 4 GO:1905710 positive regulation of membrane permeability 4/502 48/18722 0.0393179783725232 0.112028688628509 LAPTM5/HSPA1A/CHCHD10/BNIP3L 4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 4/502 48/18722 0.0393179783725232 0.112028688628509 PTPRC/PYCARD/SKIL/STK4 4 GO:0002664 regulation of T cell tolerance induction 2/502 12/18722 0.039643528595951 0.112028688628509 HLA-B/TGFBR2 2 GO:0006787 porphyrin-containing compound catabolic process 2/502 12/18722 0.039643528595951 0.112028688628509 SLCO2B1/BLVRB 2 GO:0031953 negative regulation of protein autophosphorylation 2/502 12/18722 0.039643528595951 0.112028688628509 PTPRC/ENG 2 GO:0032490 detection of molecule of bacterial origin 2/502 12/18722 0.039643528595951 0.112028688628509 LY96/TLR4 2 GO:0032736 positive regulation of interleukin-13 production 2/502 12/18722 0.039643528595951 0.112028688628509 LGALS9/HLA-E 2 GO:0032908 regulation of transforming growth factor beta1 production 2/502 12/18722 0.039643528595951 0.112028688628509 TYROBP/ATP6AP2 2 GO:0033004 negative regulation of mast cell activation 2/502 12/18722 0.039643528595951 0.112028688628509 CD84/LGALS9 2 GO:0033015 tetrapyrrole catabolic process 2/502 12/18722 0.039643528595951 0.112028688628509 SLCO2B1/BLVRB 2 GO:0034392 negative regulation of smooth muscle cell apoptotic process 2/502 12/18722 0.039643528595951 0.112028688628509 IGF1/ARRB2 2 GO:0042117 monocyte activation 2/502 12/18722 0.039643528595951 0.112028688628509 ADAM9/ADAM10 2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 2/502 12/18722 0.039643528595951 0.112028688628509 IGF1/IGFBP4 2 GO:0070572 positive regulation of neuron projection regeneration 2/502 12/18722 0.039643528595951 0.112028688628509 GRN/LRP1 2 GO:0072376 protein activation cascade 2/502 12/18722 0.039643528595951 0.112028688628509 F13A1/PRCP 2 GO:0072683 T cell extravasation 2/502 12/18722 0.039643528595951 0.112028688628509 CCL2/ICAM1 2 GO:0140289 protein mono-ADP-ribosylation 2/502 12/18722 0.039643528595951 0.112028688628509 PARP14/PARP9 2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/502 12/18722 0.039643528595951 0.112028688628509 TGFB1/DDX5 2 GO:1903909 regulation of receptor clustering 2/502 12/18722 0.039643528595951 0.112028688628509 CD81/GSN 2 GO:1904748 regulation of apoptotic process involved in development 2/502 12/18722 0.039643528595951 0.112028688628509 TNFRSF1B/TNFRSF1A 2 GO:1905245 regulation of aspartic-type peptidase activity 2/502 12/18722 0.039643528595951 0.112028688628509 GRN/LYN 2 GO:1905666 regulation of protein localization to endosome 2/502 12/18722 0.039643528595951 0.112028688628509 DTX3L/MSN 2 GO:2001204 regulation of osteoclast development 2/502 12/18722 0.039643528595951 0.112028688628509 TYROBP/ATP6AP1 2 GO:0045446 endothelial cell differentiation 7/502 118/18722 0.0396931333765547 0.112100387667852 ICAM1/RBPJ/PECAM1/NRP1/GPX1/TNFRSF1A/MSN 7 GO:0001890 placenta development 8/502 144/18722 0.0403973512694212 0.114019613772021 SPP1/CTSB/ZFP36L1/RBPJ/JUNB/HIF1A/CITED2/STK4 8 GO:0071692 protein localization to extracellular region 16/502 368/18722 0.0404425501377352 0.11407758349827 IGF1/APOE/PLEK/TLR4/HLA-DRB1/RSAD2/ADAM9/ABCA1/ALOX5/JAK2/GLUL/UCP2/TGFB1/HIF1A/LRP1/RAB8B 16 GO:0051702 biological process involved in interaction with symbiont 6/502 94/18722 0.0406988473117416 0.114730571397999 CCL3/APOE/IFI27/CCL4/GPX1/JUN 6 GO:0033555 multicellular organismal response to stress 5/502 71/18722 0.0417503525927075 0.117017568009389 MEF2C/SCN9A/APOE/NR4A2/TSPO 5 GO:0050795 regulation of behavior 5/502 71/18722 0.0417503525927075 0.117017568009389 MEF2C/CCL3/APOE/STAT3/ZFHX3 5 GO:0000305 response to oxygen radical 3/502 29/18722 0.0418014339665235 0.117017568009389 CD36/SOD2/UCP2 3 GO:0010592 positive regulation of lamellipodium assembly 3/502 29/18722 0.0418014339665235 0.117017568009389 ACTR2/CYFIP1/PIK3R1 3 GO:0019082 viral protein processing 3/502 29/18722 0.0418014339665235 0.117017568009389 MGAT4A/PARP9/MGAT1 3 GO:0021602 cranial nerve morphogenesis 3/502 29/18722 0.0418014339665235 0.117017568009389 MAFB/NRP1/CITED2 3 GO:0034311 diol metabolic process 3/502 29/18722 0.0418014339665235 0.117017568009389 ASAH1/SPTLC2/ACER3 3 GO:0002279 mast cell activation involved in immune response 4/502 49/18722 0.0419401486726257 0.117017568009389 CD84/LGALS9/SYK/LYN 4 GO:0006692 prostanoid metabolic process 4/502 49/18722 0.0419401486726257 0.117017568009389 HPGDS/CD74/TBXAS1/TNFRSF1A 4 GO:0006693 prostaglandin metabolic process 4/502 49/18722 0.0419401486726257 0.117017568009389 HPGDS/CD74/TBXAS1/TNFRSF1A 4 GO:0006778 porphyrin-containing compound metabolic process 4/502 49/18722 0.0419401486726257 0.117017568009389 SLCO2B1/BLVRB/SLC11A2/TSPO 4 GO:0009409 response to cold 4/502 49/18722 0.0419401486726257 0.117017568009389 METRNL/FOS/SOD2/UCP2 4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 4/502 49/18722 0.0419401486726257 0.117017568009389 DAB2/SDCBP/ENG/TGFB1 4 GO:0032692 negative regulation of interleukin-1 production 4/502 49/18722 0.0419401486726257 0.117017568009389 IGF1/GAS6/ARRB2/ACP5 4 GO:0072666 establishment of protein localization to vacuole 4/502 49/18722 0.0419401486726257 0.117017568009389 LAPTM5/VPS13C/LAMP2/NCOA4 4 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 4/502 49/18722 0.0419401486726257 0.117017568009389 IGF1/JAK2/GNAI2/JUN 4 GO:1904752 regulation of vascular associated smooth muscle cell migration 4/502 49/18722 0.0419401486726257 0.117017568009389 MEF2C/IQGAP1/LRP1/GNA13 4 GO:0007044 cell-substrate junction assembly 6/502 95/18722 0.0425030978098422 0.118445379800199 PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1 6 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 6/502 95/18722 0.0425030978098422 0.118445379800199 ARRB2/HSPA1A/ISG15/DTX3L/TSPO/IVNS1ABP 6 GO:0071774 response to fibroblast growth factor 7/502 120/18722 0.0428353678504772 0.119299465187422 CCL2/ZFP36L1/ZFP36/ZFP36L2/CD44/NR4A1/SETX 7 GO:1903362 regulation of cellular protein catabolic process 12/502 255/18722 0.0428994414253033 0.119406026494256 APOE/DAB2/LAPTM5/CTSC/HSPA1A/CD81/SDCBP/GPX1/MSN/NUPR1/LRP1/HERPUD1 12 GO:0002791 regulation of peptide secretion 10/502 200/18722 0.0437341755486667 0.121656221339827 CD74/HLA-DRB1/ITSN1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 10 GO:0010469 regulation of signaling receptor activity 9/502 173/18722 0.0439174228433587 0.121806022482906 MEF2C/CCL2/FCGR2B/NRP1/JAK2/IFNGR2/SNX6/NCF1/HIF1A 9 GO:0030032 lamellipodium assembly 5/502 72/18722 0.0439196812584278 0.121806022482906 CCDC88A/ACTR2/CYFIP1/WAS/PIK3R1 5 GO:0070227 lymphocyte apoptotic process 5/502 72/18722 0.0439196812584278 0.121806022482906 CD74/LGALS9/LYN/TSC22D3/HIF1A 5 GO:1901880 negative regulation of protein depolymerization 5/502 72/18722 0.0439196812584278 0.121806022482906 CAPG/CAPZA2/EPS8/GSN/TAOK1 5 GO:1903036 positive regulation of response to wounding 5/502 72/18722 0.0439196812584278 0.121806022482906 CD36/GRN/CLEC7A/XBP1/LRP1 5 GO:0003073 regulation of systemic arterial blood pressure 6/502 96/18722 0.0443568717516118 0.12287119085207 GAS6/CTSZ/CYBA/SOD2/ATP6AP2/PRCP 6 GO:0015914 phospholipid transport 6/502 96/18722 0.0443568717516118 0.12287119085207 PLTP/ATP8B4/APOE/NPC2/ABCA1/PLSCR1 6 GO:0043244 regulation of protein-containing complex disassembly 7/502 121/18722 0.0444651012293087 0.123097282038768 PLEK/SETX/CAPG/CAPZA2/EPS8/GSN/TAOK1 7 GO:0002448 mast cell mediated immunity 4/502 50/18722 0.044658837263935 0.123412055664853 CD84/LGALS9/SYK/LYN 4 GO:0071825 protein-lipid complex subunit organization 4/502 50/18722 0.044658837263935 0.123412055664853 PLTP/APOE/ABCA1/PRKACB 4 GO:1904738 vascular associated smooth muscle cell migration 4/502 50/18722 0.044658837263935 0.123412055664853 MEF2C/IQGAP1/LRP1/GNA13 4 GO:0051054 positive regulation of DNA metabolic process 10/502 201/18722 0.04497557325725 0.124031976229799 CD28/PTPRC/ARRB2/PARP9/ATM/ACTR2/DTX3L/WAS/KLF4/TGFB1 10 GO:0001649 osteoblast differentiation 11/502 229/18722 0.0452836598701511 0.124031976229799 SPP1/MEF2C/IGF1/CCL3/GPNMB/CLTC/JUNB/DDX5/DNAJC13/ATP6AP1/ADAR 11 GO:0071695 anatomical structure maturation 11/502 229/18722 0.0452836598701511 0.124031976229799 C1QA/IGF1/RB1/RBPJ/NR4A2/KLF2/CLEC7A/FOXO3/ATP6AP2/HIF1A/FEM1B 11 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/502 30/18722 0.0455511793169075 0.124031976229799 TGFB1/CAB39/CALM2 3 GO:0045070 positive regulation of viral genome replication 3/502 30/18722 0.0455511793169075 0.124031976229799 CD28/IFIT1/ADAR 3 GO:0046825 regulation of protein export from nucleus 3/502 30/18722 0.0455511793169075 0.124031976229799 GAS6/IFI27/SP100 3 GO:0070229 negative regulation of lymphocyte apoptotic process 3/502 30/18722 0.0455511793169075 0.124031976229799 CD74/TSC22D3/HIF1A 3 GO:0090314 positive regulation of protein targeting to membrane 3/502 30/18722 0.0455511793169075 0.124031976229799 ITGB2/ITGAM/PRNP 3 GO:1903579 negative regulation of ATP metabolic process 3/502 30/18722 0.0455511793169075 0.124031976229799 TSPO/NUPR1/STAT3 3 GO:1901361 organic cyclic compound catabolic process 20/502 495/18722 0.0458971560064228 0.124031976229799 SPP1/SLCO2B1/APOE/RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/SAMHD1/ZFP36/TYMP/HSPA1A/BLVRB/HNMT/ATM/BTG2/VIM/ZFP36L2/DDX5/MGAT1 20 GO:0003222 ventricular trabecula myocardium morphogenesis 2/502 13/18722 0.0460360793745277 0.124031976229799 RBPJ/ENG 2 GO:0008298 intracellular mRNA localization 2/502 13/18722 0.0460360793745277 0.124031976229799 ZFP36L1/ZFP36 2 GO:0010755 regulation of plasminogen activation 2/502 13/18722 0.0460360793745277 0.124031976229799 RUNX1/CTSZ 2 GO:0014842 regulation of skeletal muscle satellite cell proliferation 2/502 13/18722 0.0460360793745277 0.124031976229799 JAK2/STAT3 2 GO:0032352 positive regulation of hormone metabolic process 2/502 13/18722 0.0460360793745277 0.124031976229799 EGR1/HIF1A 2 GO:0032429 regulation of phospholipase A2 activity 2/502 13/18722 0.0460360793745277 0.124031976229799 PPT1/LRP1 2 GO:0032905 transforming growth factor beta1 production 2/502 13/18722 0.0460360793745277 0.124031976229799 TYROBP/ATP6AP2 2 GO:0033700 phospholipid efflux 2/502 13/18722 0.0460360793745277 0.124031976229799 APOE/ABCA1 2 GO:0034112 positive regulation of homotypic cell-cell adhesion 2/502 13/18722 0.0460360793745277 0.124031976229799 JAK2/LGALS1 2 GO:0034135 regulation of toll-like receptor 2 signaling pathway 2/502 13/18722 0.0460360793745277 0.124031976229799 CYBA/LYN 2 GO:0035745 T-helper 2 cell cytokine production 2/502 13/18722 0.0460360793745277 0.124031976229799 RSAD2/CD81 2 GO:0036005 response to macrophage colony-stimulating factor 2/502 13/18722 0.0460360793745277 0.124031976229799 CSF1R/TLR4 2 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 2/502 13/18722 0.0460360793745277 0.124031976229799 CSF1R/TLR4 2 GO:0036302 atrioventricular canal development 2/502 13/18722 0.0460360793745277 0.124031976229799 RBPJ/ENG 2 GO:0042541 hemoglobin biosynthetic process 2/502 13/18722 0.0460360793745277 0.124031976229799 KLF4/HIF1A 2 GO:0046642 negative regulation of alpha-beta T cell proliferation 2/502 13/18722 0.0460360793745277 0.124031976229799 LGALS9/TNFRSF14 2 GO:0048266 behavioral response to pain 2/502 13/18722 0.0460360793745277 0.124031976229799 SCN9A/TSPO 2 GO:0048302 regulation of isotype switching to IgG isotypes 2/502 13/18722 0.0460360793745277 0.124031976229799 CD28/PTPRC 2 GO:0051481 negative regulation of cytosolic calcium ion concentration 2/502 13/18722 0.0460360793745277 0.124031976229799 SLC8A1/LRP1 2 GO:0051709 regulation of killing of cells of other organism 2/502 13/18722 0.0460360793745277 0.124031976229799 SYK/CLEC7A 2 GO:0060100 positive regulation of phagocytosis, engulfment 2/502 13/18722 0.0460360793745277 0.124031976229799 CD36/NCKAP1L 2 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/502 13/18722 0.0460360793745277 0.124031976229799 ZFP36/BTG2 2 GO:0061469 regulation of type B pancreatic cell proliferation 2/502 13/18722 0.0460360793745277 0.124031976229799 NR4A1/NUPR1 2 GO:0070486 leukocyte aggregation 2/502 13/18722 0.0460360793745277 0.124031976229799 CD44/MSN 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/502 13/18722 0.0460360793745277 0.124031976229799 XBP1/PIK3R1 2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/502 13/18722 0.0460360793745277 0.124031976229799 SKIL/STK4 2 GO:1903651 positive regulation of cytoplasmic transport 2/502 13/18722 0.0460360793745277 0.124031976229799 DAB2/MSN 2 GO:1903977 positive regulation of glial cell migration 2/502 13/18722 0.0460360793745277 0.124031976229799 CCL3/LRP1 2 GO:1905155 positive regulation of membrane invagination 2/502 13/18722 0.0460360793745277 0.124031976229799 CD36/NCKAP1L 2 GO:1905244 regulation of modification of synaptic structure 2/502 13/18722 0.0460360793745277 0.124031976229799 ITSN1/CYFIP1 2 GO:1905939 regulation of gonad development 2/502 13/18722 0.0460360793745277 0.124031976229799 NUPR1/CITED2 2 GO:2000318 positive regulation of T-helper 17 type immune response 2/502 13/18722 0.0460360793745277 0.124031976229799 CLEC7A/NFKBIZ 2 GO:2000551 regulation of T-helper 2 cell cytokine production 2/502 13/18722 0.0460360793745277 0.124031976229799 RSAD2/CD81 2 GO:0032388 positive regulation of intracellular transport 10/502 202/18722 0.0462406386494898 0.124346729679612 GAS6/DAB2/ITGB2/ITGAM/PRNP/CD81/JAK2/TGFB1/MSN/PIK3R1 10 GO:0090087 regulation of peptide transport 10/502 202/18722 0.0462406386494898 0.124346729679612 CD74/HLA-DRB1/ITSN1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 10 GO:0010596 negative regulation of endothelial cell migration 6/502 97/18722 0.0462604240766562 0.124346729679612 MEF2C/SPRED1/APOE/KLF4/TGFB1/SP100 6 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 6/502 97/18722 0.0462604240766562 0.124346729679612 IGF1/ICAM1/HSPA1A/NRP1/GPX1/MCL1 6 GO:0016197 endosomal transport 11/502 230/18722 0.0464668944616721 0.124829183379614 ITSN1/ABCA1/EHD4/CLTC/EPS15/ITSN2/SNX6/WAS/ACAP2/ARL4C/SNX2 11 GO:0010656 negative regulation of muscle cell apoptotic process 4/502 51/18722 0.0474739208604029 0.12716523329486 IGF1/ARRB2/JAK2/NUPR1 4 GO:0010874 regulation of cholesterol efflux 4/502 51/18722 0.0474739208604029 0.12716523329486 PLTP/APOE/ABCA1/LRP1 4 GO:0032873 negative regulation of stress-activated MAPK cascade 4/502 51/18722 0.0474739208604029 0.12716523329486 SIRPA/DUSP1/DUSP3/TAOK3 4 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 4/502 51/18722 0.0474739208604029 0.12716523329486 SIRPA/DUSP1/DUSP3/TAOK3 4 GO:1903307 positive regulation of regulated secretory pathway 4/502 51/18722 0.0474739208604029 0.12716523329486 ITGB2/ITGAM/SYK/LAMP1 4 GO:0032869 cellular response to insulin stimulus 10/502 203/18722 0.0475295219673546 0.127240491100105 MYO5A/ZFP36L1/PDK4/XBP1/UCP2/CYFIP1/STAT1/GNAI2/PIK3R1/RAB8B 10 GO:0003231 cardiac ventricle development 7/502 123/18722 0.0478429787104535 0.12800556362901 MEF2C/RBPJ/TGFBR2/ENG/TGFB1/HIF1A/CITED2 7 GO:0061564 axon development 19/502 467/18722 0.0479564758485196 0.128235062008816 SPP1/APOE/PLXND1/ARHGAP4/NR4A2/GRN/NRP1/ACTB/JAK2/EMB/TSPO/CYFIP1/KLF4/RTN4/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 19 GO:0070301 cellular response to hydrogen peroxide 6/502 98/18722 0.0482139820047395 0.128849151215439 KLF2/SIRPA/FOXO3/KLF4/SETX/RHOB 6 GO:0051091 positive regulation of DNA-binding transcription factor activity 12/502 260/18722 0.0484312529225418 0.129351030015822 CD36/ICAM1/TLR4/LGALS9/HSPA1A/MTDH/CLEC7A/JAK2/PYCARD/TRIM22/STAT3/TRIM38 12 GO:0046323 glucose import 5/502 74/18722 0.048457703203074 0.129351030015822 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:0071383 cellular response to steroid hormone stimulus 10/502 204/18722 0.048842368125617 0.130302649912978 DAB2/ICAM1/ZFP36L1/ZFP36/JAK2/ZFP36L2/FOXO3/NCOA4/DDX17/DDX5 10 GO:0001516 prostaglandin biosynthetic process 3/502 31/18722 0.0494615105410868 0.131258727791985 HPGDS/CD74/TBXAS1 3 GO:0030212 hyaluronan metabolic process 3/502 31/18722 0.0494615105410868 0.131258727791985 CLTC/CD44/TGFB1 3 GO:0032148 activation of protein kinase B activity 3/502 31/18722 0.0494615105410868 0.131258727791985 IGF1/GAS6/CCDC88A 3 GO:0033238 regulation of cellular amine metabolic process 3/502 31/18722 0.0494615105410868 0.131258727791985 ITGB2/ITGAM/NR4A2 3 GO:0046457 prostanoid biosynthetic process 3/502 31/18722 0.0494615105410868 0.131258727791985 HPGDS/CD74/TBXAS1 3 GO:0065005 protein-lipid complex assembly 3/502 31/18722 0.0494615105410868 0.131258727791985 APOE/ABCA1/PRKACB 3 GO:0071480 cellular response to gamma radiation 3/502 31/18722 0.0494615105410868 0.131258727791985 CYBA/ATM/EGR1 3 GO:0090162 establishment of epithelial cell polarity 3/502 31/18722 0.0494615105410868 0.131258727791985 FRMD4B/CYTH1/MSN 3 GO:1900027 regulation of ruffle assembly 3/502 31/18722 0.0494615105410868 0.131258727791985 ICAM1/CYFIP1/EPS8 3 GO:0098739 import across plasma membrane 9/502 177/18722 0.0494844836293172 0.131258727791985 FOLR2/SLC9A9/ATP1B1/CD36/SLC2A3/PRNP/SLC15A3/SLC8A1/SLC1A3 9 GO:0034504 protein localization to nucleus 13/502 290/18722 0.0497867969026729 0.131984941244564 CD36/TXNIP/SYK/PARP9/JAK2/GLUL/DTX3L/TGFB1/STAT3/SP100/CHCHD10/RANBP2/PIK3R1 13 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 11/502 233/18722 0.0501427330152558 0.132852395720832 PSAP/RGS1/PTGER4/ABCA1/FPR1/GPR65/PRKACB/ADCY7/GNAI2/GNA13/AKAP13 11 GO:0010717 regulation of epithelial to mesenchymal transition 6/502 99/18722 0.0502177449928302 0.132974979013642 SPRED1/DAB2/TGFBR2/SDCBP/ENG/TGFB1 6 GO:0021545 cranial nerve development 4/502 52/18722 0.0503851693921379 0.133265748203562 MAFB/NRP1/SLC1A3/CITED2 4 GO:0035196 production of miRNAs involved in gene silencing by miRNA 4/502 52/18722 0.0503851693921379 0.133265748203562 TGFB1/STAT3/DDX5/ADAR 4 GO:0031330 negative regulation of cellular catabolic process 12/502 262/18722 0.0507749632996018 0.134203357193091 TIMP2/IL10RA/CST3/ZFP36/NAMPT/ATG7/SDCBP/TSPO/MCL1/NUPR1/TIMP1/STAT3 12 GO:0036465 synaptic vesicle recycling 5/502 75/18722 0.0508266929966052 0.134203357193091 ITSN1/ACTB/ITSN2/CYFIP1/FCHO2 5 GO:2001259 positive regulation of cation channel activity 5/502 75/18722 0.0508266929966052 0.134203357193091 CCL2/TMSB4X/CTSS/IFNGR2/CALM2 5 GO:0048863 stem cell differentiation 10/502 206/18722 0.0515405015156079 0.136010473480435 A2M/MEF2C/PTPRC/RBPJ/NRP1/ZFP36L2/N4BP2L2/STAT3/HIF1A/CITED2 10 GO:0046545 development of primary female sexual characteristics 6/502 100/18722 0.0522718847244291 0.137390545167787 ICAM1/ARRB2/LHFPL2/FOXO3/NRIP1/NUPR1 6 GO:0007626 locomotory behavior 9/502 179/18722 0.0524350211770522 0.137390545167787 HPGDS/APOE/NR4A2/ARRB2/EGR1/PPT1/ZFHX3/GAA/EPS8 9 GO:0021915 neural tube development 8/502 152/18722 0.0525351518467429 0.137390545167787 ZFP36L1/TGFB1/PRKACB/ATP6AP2/HIF1A/CITED2/STK4/PLXNB2 8 GO:0098754 detoxification 8/502 152/18722 0.0525351518467429 0.137390545167787 APOE/CD36/ALDH1A1/ALOX5AP/SOD2/GPX1/MGST2/SESN1 8 GO:0002467 germinal center formation 2/502 14/18722 0.0527762643240722 0.137390545167787 MEF2C/TNFSF13B 2 GO:0002475 antigen processing and presentation via MHC class Ib 2/502 14/18722 0.0527762643240722 0.137390545167787 B2M/HLA-E 2 GO:0002517 T cell tolerance induction 2/502 14/18722 0.0527762643240722 0.137390545167787 HLA-B/TGFBR2 2 GO:0002864 regulation of acute inflammatory response to antigenic stimulus 2/502 14/18722 0.0527762643240722 0.137390545167787 FCGR2B/HLA-E 2 GO:0003214 cardiac left ventricle morphogenesis 2/502 14/18722 0.0527762643240722 0.137390545167787 RBPJ/TGFBR2 2 GO:0006047 UDP-N-acetylglucosamine metabolic process 2/502 14/18722 0.0527762643240722 0.137390545167787 MGAT1/GNPDA1 2 GO:0030213 hyaluronan biosynthetic process 2/502 14/18722 0.0527762643240722 0.137390545167787 CLTC/TGFB1 2 GO:0035563 positive regulation of chromatin binding 2/502 14/18722 0.0527762643240722 0.137390545167787 PARP9/DTX3L 2 GO:0036295 cellular response to increased oxygen levels 2/502 14/18722 0.0527762643240722 0.137390545167787 ATG7/ATP6AP1 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/502 14/18722 0.0527762643240722 0.137390545167787 RUNX1/NCKAP1L 2 GO:0045059 positive thymic T cell selection 2/502 14/18722 0.0527762643240722 0.137390545167787 CD74/PTPRC 2 GO:0045820 negative regulation of glycolytic process 2/502 14/18722 0.0527762643240722 0.137390545167787 NUPR1/STAT3 2 GO:0048291 isotype switching to IgG isotypes 2/502 14/18722 0.0527762643240722 0.137390545167787 CD28/PTPRC 2 GO:0061043 regulation of vascular wound healing 2/502 14/18722 0.0527762643240722 0.137390545167787 ALOX5/XBP1 2 GO:0071236 cellular response to antibiotic 2/502 14/18722 0.0527762643240722 0.137390545167787 MEF2C/ACTR2 2 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 2/502 14/18722 0.0527762643240722 0.137390545167787 GNAI2/AKAP13 2 GO:1901857 positive regulation of cellular respiration 2/502 14/18722 0.0527762643240722 0.137390545167787 NUPR1/IFNAR1 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/502 14/18722 0.0527762643240722 0.137390545167787 CD74/CD44 2 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 2/502 14/18722 0.0527762643240722 0.137390545167787 SOD2/ENG 2 GO:2001171 positive regulation of ATP biosynthetic process 2/502 14/18722 0.0527762643240722 0.137390545167787 TMSB4X/STAT3 2 GO:2001235 positive regulation of apoptotic signaling pathway 7/502 126/18722 0.0532088571132794 0.138032013057644 CTSC/PTPRC/PYCARD/MCL1/NUPR1/SKIL/STK4 7 GO:0001937 negative regulation of endothelial cell proliferation 5/502 76/18722 0.0532624488946913 0.138032013057644 MEF2C/CCL2/APOE/ALOX5/STAT1 5 GO:0008652 cellular amino acid biosynthetic process 5/502 76/18722 0.0532624488946913 0.138032013057644 ALDH1A1/GLUL/BCAT1/GLS/SLC1A3 5 GO:0014823 response to activity 5/502 76/18722 0.0532624488946913 0.138032013057644 CYBA/METRNL/SOD2/HIF1A/CAB39 5 GO:0031100 animal organ regeneration 5/502 76/18722 0.0532624488946913 0.138032013057644 GAS6/C5AR1/LCP1/TGFBR2/UCP2 5 GO:0034381 plasma lipoprotein particle clearance 4/502 53/18722 0.0533922492130574 0.138032013057644 APOE/CD36/MSR1/LIPA 4 GO:0043113 receptor clustering 4/502 53/18722 0.0533922492130574 0.138032013057644 APOE/ITGB2/CD81/GSN 4 GO:0071320 cellular response to cAMP 4/502 53/18722 0.0533922492130574 0.138032013057644 ZFP36L1/ITPR2/SLC8A1/AHR 4 GO:1903202 negative regulation of oxidative stress-induced cell death 4/502 53/18722 0.0533922492130574 0.138032013057644 SOD2/ATG7/GPX1/HIF1A 4 GO:0007435 salivary gland morphogenesis 3/502 32/18722 0.053529924648814 0.138032013057644 PLXND1/NRP1/TGFB1 3 GO:0010644 cell communication by electrical coupling 3/502 32/18722 0.053529924648814 0.138032013057644 ATP1B1/SLC8A1/CALM2 3 GO:0010743 regulation of macrophage derived foam cell differentiation 3/502 32/18722 0.053529924648814 0.138032013057644 CD36/MSR1/ABCA1 3 GO:0019835 cytolysis 3/502 32/18722 0.053529924648814 0.138032013057644 CR1/NINJ1/TGFB1 3 GO:0097345 mitochondrial outer membrane permeabilization 3/502 32/18722 0.053529924648814 0.138032013057644 HSPA1A/CHCHD10/BNIP3L 3 GO:1900745 positive regulation of p38MAPK cascade 3/502 32/18722 0.053529924648814 0.138032013057644 SPI1/GADD45B/NCF1 3 GO:1901185 negative regulation of ERBB signaling pathway 3/502 32/18722 0.053529924648814 0.138032013057644 LGMN/SNX6/DUSP3 3 GO:1905476 negative regulation of protein localization to membrane 3/502 32/18722 0.053529924648814 0.138032013057644 DAB2/CLTC/TGFB1 3 GO:0051604 protein maturation 13/502 294/18722 0.0543653531771557 0.140108146962408 RUNX1/LGMN/CTSS/CTSZ/IFI16/SRGN/PRNP/PYCARD/CPM/PRKACB/ATP6AP2/GSN/ADAM10 13 GO:1905952 regulation of lipid localization 9/502 181/18722 0.0554984583645799 0.142948701778701 SPP1/PLTP/APOE/CD36/MSR1/SYK/ABCA1/TSPO/LRP1 9 GO:0046700 heterocycle catabolic process 18/502 445/18722 0.0556251097308031 0.143195190659263 SLCO2B1/RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/SAMHD1/ZFP36/TYMP/HSPA1A/BLVRB/HNMT/ATM/BTG2/VIM/ZFP36L2/DDX5/MGAT1 18 GO:0002200 somatic diversification of immune receptors 5/502 77/18722 0.0557649938018292 0.143395698347561 CD28/PTPRC/SAMHD1/TGFB1/ADAR 5 GO:0140056 organelle localization by membrane tethering 5/502 77/18722 0.0557649938018292 0.143395698347561 PLEK/VMP1/STX7/STX12/RAB8B 5 GO:0031050 dsRNA processing 4/502 54/18722 0.0564947263822408 0.145030302022334 TGFB1/STAT3/DDX5/ADAR 4 GO:0070918 production of small RNA involved in gene silencing by RNA 4/502 54/18722 0.0564947263822408 0.145030302022334 TGFB1/STAT3/DDX5/ADAR 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/502 54/18722 0.0564947263822408 0.145030302022334 CTSZ/LYN/GNAI2/HIF1A 4 GO:0001841 neural tube formation 6/502 102/18722 0.0565318424400401 0.145045093248822 TGFB1/PRKACB/HIF1A/CITED2/STK4/PLXNB2 6 GO:0006606 protein import into nucleus 8/502 155/18722 0.0576311145690296 0.147783556538986 CD36/TXNIP/SYK/JAK2/TGFB1/STAT3/RANBP2/PIK3R1 8 GO:0035025 positive regulation of Rho protein signal transduction 3/502 33/18722 0.0577537032703181 0.147933904390084 LPAR6/GPR65/AKAP13 3 GO:0071353 cellular response to interleukin-4 3/502 33/18722 0.0577537032703181 0.147933904390084 MRC1/PARP14/XBP1 3 GO:0032024 positive regulation of insulin secretion 5/502 78/18722 0.0583343015548754 0.148926312909963 HLA-DRB1/JAK2/GLUL/HIF1A/LRP1 5 GO:0032371 regulation of sterol transport 5/502 78/18722 0.0583343015548754 0.148926312909963 PLTP/APOE/ABCA1/TSPO/LRP1 5 GO:0032374 regulation of cholesterol transport 5/502 78/18722 0.0583343015548754 0.148926312909963 PLTP/APOE/ABCA1/TSPO/LRP1 5 GO:0035050 embryonic heart tube development 5/502 78/18722 0.0583343015548754 0.148926312909963 MEF2C/TGFBR2/ENG/HIF1A/CITED2 5 GO:0043537 negative regulation of blood vessel endothelial cell migration 5/502 78/18722 0.0583343015548754 0.148926312909963 MEF2C/SPRED1/APOE/KLF4/TGFB1 5 GO:0090559 regulation of membrane permeability 5/502 78/18722 0.0583343015548754 0.148926312909963 LAPTM5/HSPA1A/STAT3/CHCHD10/BNIP3L 5 GO:0003179 heart valve morphogenesis 4/502 55/18722 0.0596920700056578 0.150611602057615 MEF2C/RB1/TGFBR2/TGFB1 4 GO:0045620 negative regulation of lymphocyte differentiation 4/502 55/18722 0.0596920700056578 0.150611602057615 CR1/RUNX1/CD74/FGL2 4 GO:0048016 inositol phosphate-mediated signaling 4/502 55/18722 0.0596920700056578 0.150611602057615 IGF1/ITPR2/PRNP/CLEC7A 4 GO:0002070 epithelial cell maturation 2/502 15/18722 0.0598409261958272 0.150611602057615 HIF1A/FEM1B 2 GO:0002679 respiratory burst involved in defense response 2/502 15/18722 0.0598409261958272 0.150611602057615 GRN/NCF1 2 GO:0006684 sphingomyelin metabolic process 2/502 15/18722 0.0598409261958272 0.150611602057615 SGMS1/SPTLC2 2 GO:0010763 positive regulation of fibroblast migration 2/502 15/18722 0.0598409261958272 0.150611602057615 SLC8A1/TGFB1 2 GO:0014744 positive regulation of muscle adaptation 2/502 15/18722 0.0598409261958272 0.150611602057615 AIF1/FOXO3 2 GO:0014841 skeletal muscle satellite cell proliferation 2/502 15/18722 0.0598409261958272 0.150611602057615 JAK2/STAT3 2 GO:0014857 regulation of skeletal muscle cell proliferation 2/502 15/18722 0.0598409261958272 0.150611602057615 JAK2/STAT3 2 GO:0032486 Rap protein signal transduction 2/502 15/18722 0.0598409261958272 0.150611602057615 TIMP2/RAP2B 2 GO:0032897 negative regulation of viral transcription 2/502 15/18722 0.0598409261958272 0.150611602057615 IFITM3/ZFP36 2 GO:0033599 regulation of mammary gland epithelial cell proliferation 2/502 15/18722 0.0598409261958272 0.150611602057615 GPX1/RTN4 2 GO:0034638 phosphatidylcholine catabolic process 2/502 15/18722 0.0598409261958272 0.150611602057615 ENPP2/PLA2G15 2 GO:0035627 ceramide transport 2/502 15/18722 0.0598409261958272 0.150611602057615 PLTP/PSAP 2 GO:0036376 sodium ion export across plasma membrane 2/502 15/18722 0.0598409261958272 0.150611602057615 ATP1B1/SLC8A1 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/502 15/18722 0.0598409261958272 0.150611602057615 CD74/CD44 2 GO:0045217 cell-cell junction maintenance 2/502 15/18722 0.0598409261958272 0.150611602057615 CSF1R/MTSS1 2 GO:0045475 locomotor rhythm 2/502 15/18722 0.0598409261958272 0.150611602057615 EGR1/ZFHX3 2 GO:0055012 ventricular cardiac muscle cell differentiation 2/502 15/18722 0.0598409261958272 0.150611602057615 MEF2C/MEF2A 2 GO:0060099 regulation of phagocytosis, engulfment 2/502 15/18722 0.0598409261958272 0.150611602057615 CD36/NCKAP1L 2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/502 15/18722 0.0598409261958272 0.150611602057615 ZFP36/BTG2 2 GO:1900029 positive regulation of ruffle assembly 2/502 15/18722 0.0598409261958272 0.150611602057615 CYFIP1/EPS8 2 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 2/502 15/18722 0.0598409261958272 0.150611602057615 TGFB1/STAT3 2 GO:1905168 positive regulation of double-strand break repair via homologous recombination 2/502 15/18722 0.0598409261958272 0.150611602057615 ACTR2/WAS 2 GO:2001028 positive regulation of endothelial cell chemotaxis 2/502 15/18722 0.0598409261958272 0.150611602057615 LGMN/TMSB4X 2 GO:0032272 negative regulation of protein polymerization 5/502 79/18722 0.0609702976060457 0.153265271672735 TMSB4X/CAPG/CAPZA2/EPS8/GSN 5 GO:0051279 regulation of release of sequestered calcium ion into cytosol 5/502 79/18722 0.0609702976060457 0.153265271672735 CYBA/SLC8A1/LYN/PTPN6/CALM2 5 GO:0014896 muscle hypertrophy 6/502 104/18722 0.0609946746972556 0.153265271672735 IGF1/CYBA/TNFRSF1B/MEF2A/TNFRSF1A/AKAP13 6 GO:1902600 proton transmembrane transport 8/502 157/18722 0.0611965093606699 0.153688953475819 SLC9A9/TMSB4X/SLC15A3/SLC11A2/ATP6V0A1/UCP2/ATP6V0B/ATP6AP1 8 GO:0044270 cellular nitrogen compound catabolic process 18/502 451/18722 0.0616127247620915 0.154650279299748 SLCO2B1/RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/SAMHD1/ZFP36/TYMP/HSPA1A/BLVRB/HNMT/ATM/BTG2/VIM/ZFP36L2/DDX5/MGAT1 18 GO:1901987 regulation of cell cycle phase transition 16/502 390/18722 0.0618186382614075 0.154856177893765 CCL2/AIF1/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/NABP1/PTPN6/TAOK3/FEM1B/ATF5/TAOK1/KMT2E 16 GO:0007095 mitotic G2 DNA damage checkpoint signaling 3/502 34/18722 0.0621299321597119 0.154856177893765 ATM/TAOK3/TAOK1 3 GO:0007431 salivary gland development 3/502 34/18722 0.0621299321597119 0.154856177893765 PLXND1/NRP1/TGFB1 3 GO:0007616 long-term memory 3/502 34/18722 0.0621299321597119 0.154856177893765 APOE/PRNP/SGK1 3 GO:0014072 response to isoquinoline alkaloid 3/502 34/18722 0.0621299321597119 0.154856177893765 AIF1/ATG7/FOSB 3 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/502 34/18722 0.0621299321597119 0.154856177893765 CCL3/SLC8A1/CALM2 3 GO:0035909 aorta morphogenesis 3/502 34/18722 0.0621299321597119 0.154856177893765 RBPJ/ENG/LRP1 3 GO:0043278 response to morphine 3/502 34/18722 0.0621299321597119 0.154856177893765 AIF1/ATG7/FOSB 3 GO:0050931 pigment cell differentiation 3/502 34/18722 0.0621299321597119 0.154856177893765 MEF2C/ZEB2/CD63 3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 3/502 34/18722 0.0621299321597119 0.154856177893765 LPAR6/C3AR1/GPR65 3 GO:0070232 regulation of T cell apoptotic process 3/502 34/18722 0.0621299321597119 0.154856177893765 LGALS9/TSC22D3/HIF1A 3 GO:0070884 regulation of calcineurin-NFAT signaling cascade 3/502 34/18722 0.0621299321597119 0.154856177893765 IGF1/PRNP/CLEC7A 3 GO:0090075 relaxation of muscle 3/502 34/18722 0.0621299321597119 0.154856177893765 ATP1B1/SLC8A1/GSN 3 GO:0002790 peptide secretion 11/502 242/18722 0.0623324176063064 0.155277201856098 CD74/HLA-DRB1/ITSN1/ABCA1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 11 GO:0006612 protein targeting to membrane 7/502 131/18722 0.0629598750843202 0.156478190615058 ITGB2/ITGAM/PRNP/SDCBP/NCF1/TRAM1/RAB8B 7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/502 56/18722 0.0629836556258621 0.156478190615058 ZFP36L1/ZFP36/BTG2/ZFP36L2 4 GO:0002090 regulation of receptor internalization 4/502 56/18722 0.0629836556258621 0.156478190615058 SYK/ARRB2/CD63/SDCBP 4 GO:0043470 regulation of carbohydrate catabolic process 4/502 56/18722 0.0629836556258621 0.156478190615058 IGF1/NUPR1/STAT3/HIF1A 4 GO:0055078 sodium ion homeostasis 4/502 56/18722 0.0629836556258621 0.156478190615058 ATP1B1/SLC8A1/GNAI2/SLC1A3 4 GO:0006913 nucleocytoplasmic transport 13/502 301/18722 0.0630517587762411 0.156479311211852 GAS6/IFI27/CD36/TXNIP/MX2/SYK/JAK2/TGFB1/STAT3/SP100/RANBP2/PIK3R1/AKAP13 13 GO:0051169 nuclear transport 13/502 301/18722 0.0630517587762411 0.156479311211852 GAS6/IFI27/CD36/TXNIP/MX2/SYK/JAK2/TGFB1/STAT3/SP100/RANBP2/PIK3R1/AKAP13 13 GO:0000041 transition metal ion transport 6/502 105/18722 0.0633023044698611 0.156848666565387 FTL/B2M/MCOLN1/CLTC/FTH1/SLC11A2 6 GO:0040029 regulation of gene expression, epigenetic 6/502 105/18722 0.0633023044698611 0.156848666565387 IFI16/XIST/SPI1/KLF2/GPX1/ATF7IP 6 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 6/502 105/18722 0.0633023044698611 0.156848666565387 CCDC88A/NRP1/ACTR2/CYFIP1/EPS8/PIK3R1 6 GO:1901264 carbohydrate derivative transport 5/502 80/18722 0.0636728597567857 0.157682360404117 PLTP/CR1/NPC2/PSAP/SLC15A3 5 GO:0051170 import into nucleus 8/502 159/18722 0.0648973340202231 0.160542816672488 CD36/TXNIP/SYK/JAK2/TGFB1/STAT3/RANBP2/PIK3R1 8 GO:1903169 regulation of calcium ion transmembrane transport 8/502 159/18722 0.0648973340202231 0.160542816672488 ATP1B1/CYBA/VMP1/PRNP/SLC8A1/LYN/PTPN6/CALM2 8 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 12/502 273/18722 0.0650469138822244 0.160826843195708 CD209/CD84/ITGB2/ICAM1/ITGAM/PECAM1/EMB/TGFBR2/KLF4/FXYD5/CD164/PLXNB2 12 GO:0006090 pyruvate metabolic process 6/502 106/18722 0.0656607610990095 0.161848569189444 IGF1/PDK4/NUPR1/STAT3/HIF1A/ME2 6 GO:0030038 contractile actin filament bundle assembly 6/502 106/18722 0.0656607610990095 0.161848569189444 CCDC88A/PTGER4/NRP1/GPR65/WAS/PIK3R1 6 GO:0043149 stress fiber assembly 6/502 106/18722 0.0656607610990095 0.161848569189444 CCDC88A/PTGER4/NRP1/GPR65/WAS/PIK3R1 6 GO:1905477 positive regulation of protein localization to membrane 6/502 106/18722 0.0656607610990095 0.161848569189444 ITGB2/ITGAM/PRNP/CD81/LRP1/PIK3R1 6 GO:0044772 mitotic cell cycle phase transition 17/502 424/18722 0.0656700744419773 0.161848569189444 CCL2/AIF1/GPNMB/ZFP36L1/RB1/ATM/DUSP1/ZFP36L2/KLF4/BCAT1/NABP1/PTPN6/TAOK3/EPS8/CALM2/TAOK1/KMT2E 17 GO:0048608 reproductive structure development 17/502 424/18722 0.0656700744419773 0.161848569189444 SPP1/CTSB/ICAM1/PSAP/ZFP36L1/RBPJ/ARRB2/JUNB/FOXO3/NRIP1/NUPR1/NCOA4/PTPN6/HIF1A/FEM1B/CITED2/STK4 17 GO:0006611 protein export from nucleus 4/502 57/18722 0.066368768648107 0.16243663728553 GAS6/IFI27/TGFB1/SP100 4 GO:0051155 positive regulation of striated muscle cell differentiation 4/502 57/18722 0.066368768648107 0.16243663728553 MEF2C/IGF1/ARRB2/TGFB1 4 GO:0061005 cell differentiation involved in kidney development 4/502 57/18722 0.066368768648107 0.16243663728553 MEF2C/MTSS1/IQGAP1/STAT1 4 GO:0000422 autophagy of mitochondrion 5/502 81/18722 0.0664418189392302 0.16243663728553 VPS13C/ATG7/TSPO/HIF1A/BNIP3L 5 GO:0061726 mitochondrion disassembly 5/502 81/18722 0.0664418189392302 0.16243663728553 VPS13C/ATG7/TSPO/HIF1A/BNIP3L 5 GO:0034331 cell junction maintenance 3/502 35/18722 0.0666555196475921 0.16243663728553 CSF1R/MTSS1/CHCHD10 3 GO:0098801 regulation of renal system process 3/502 35/18722 0.0666555196475921 0.16243663728553 GAS6/CYBA/GNAI2 3 GO:0106056 regulation of calcineurin-mediated signaling 3/502 35/18722 0.0666555196475921 0.16243663728553 IGF1/PRNP/CLEC7A 3 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 3/502 35/18722 0.0666555196475921 0.16243663728553 CCL3/SLC8A1/CALM2 3 GO:1905207 regulation of cardiocyte differentiation 3/502 35/18722 0.0666555196475921 0.16243663728553 MEF2C/ARRB2/TGFB1 3 GO:0090316 positive regulation of intracellular protein transport 8/502 160/18722 0.0667987323228482 0.16243663728553 GAS6/ITGB2/ITGAM/PRNP/CD81/JAK2/TGFB1/PIK3R1 8 GO:0009314 response to radiation 18/502 456/18722 0.0669308933270606 0.16243663728553 ICAM1/IFI16/CYBA/PTPRC/FOS/NAMPT/SOD2/ATM/EGR1/DUSP1/GPX1/NABP1/TIMP1/HIF1A/SLC1A3/JUN/RHOB/PIK3R1 18 GO:0030308 negative regulation of cell growth 9/502 188/18722 0.0671230822502734 0.16243663728553 SPP1/BST2/ARHGAP4/RB1/HSPA1A/NRP1/PPT1/TGFB1/RTN4 9 GO:0001977 renal system process involved in regulation of blood volume 2/502 16/18722 0.0672078953230662 0.16243663728553 GAS6/CYBA 2 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/502 16/18722 0.0672078953230662 0.16243663728553 CTSZ/ATP6AP2 2 GO:0002566 somatic diversification of immune receptors via somatic mutation 2/502 16/18722 0.0672078953230662 0.16243663728553 SAMHD1/ADAR 2 GO:0005980 glycogen catabolic process 2/502 16/18722 0.0672078953230662 0.16243663728553 PYGL/GAA 2 GO:0010649 regulation of cell communication by electrical coupling 2/502 16/18722 0.0672078953230662 0.16243663728553 SLC8A1/CALM2 2 GO:0019377 glycolipid catabolic process 2/502 16/18722 0.0672078953230662 0.16243663728553 FUCA1/HEXA 2 GO:0033631 cell-cell adhesion mediated by integrin 2/502 16/18722 0.0672078953230662 0.16243663728553 ADAM9/FERMT3 2 GO:0034375 high-density lipoprotein particle remodeling 2/502 16/18722 0.0672078953230662 0.16243663728553 PLTP/APOE 2 GO:0034393 positive regulation of smooth muscle cell apoptotic process 2/502 16/18722 0.0672078953230662 0.16243663728553 SOD2/STK4 2 GO:0045651 positive regulation of macrophage differentiation 2/502 16/18722 0.0672078953230662 0.16243663728553 RB1/TGFB1 2 GO:0048385 regulation of retinoic acid receptor signaling pathway 2/502 16/18722 0.0672078953230662 0.16243663728553 KLF2/DHRS3 2 GO:0051238 sequestering of metal ion 2/502 16/18722 0.0672078953230662 0.16243663728553 FTL/FTH1 2 GO:0055089 fatty acid homeostasis 2/502 16/18722 0.0672078953230662 0.16243663728553 APOE/XBP1 2 GO:0060330 regulation of response to interferon-gamma 2/502 16/18722 0.0672078953230662 0.16243663728553 PARP14/PARP9 2 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/502 16/18722 0.0672078953230662 0.16243663728553 PARP14/PARP9 2 GO:0061684 chaperone-mediated autophagy 2/502 16/18722 0.0672078953230662 0.16243663728553 ATG7/LAMP2 2 GO:0072148 epithelial cell fate commitment 2/502 16/18722 0.0672078953230662 0.16243663728553 RBPJ/NRP1 2 GO:0099010 modification of postsynaptic structure 2/502 16/18722 0.0672078953230662 0.16243663728553 ITSN1/CYFIP1 2 GO:1901163 regulation of trophoblast cell migration 2/502 16/18722 0.0672078953230662 0.16243663728553 ARHGDIB/TIMP1 2 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/502 16/18722 0.0672078953230662 0.16243663728553 CD74/CD44 2 GO:1902931 negative regulation of alcohol biosynthetic process 2/502 16/18722 0.0672078953230662 0.16243663728553 APOE/PLEK 2 GO:1905153 regulation of membrane invagination 2/502 16/18722 0.0672078953230662 0.16243663728553 CD36/NCKAP1L 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/502 16/18722 0.0672078953230662 0.16243663728553 PARP9/DTX3L 2 GO:2001044 regulation of integrin-mediated signaling pathway 2/502 16/18722 0.0672078953230662 0.16243663728553 CD63/TIMP1 2 GO:0043270 positive regulation of ion transport 12/502 275/18722 0.067898524597511 0.164020143492473 CCL2/ATP1B1/CCL3/TMSB4X/CTSS/CCR1/CCL4/VMP1/ARRB2/IFNGR2/TSPO/CALM2 12 GO:0032526 response to retinoic acid 6/502 107/18722 0.0680700240862076 0.164348607214403 ABCA1/LYN/ATM/DUSP1/KLF4/SETX 6 GO:0061458 reproductive system development 17/502 427/18722 0.0690897828736352 0.166723701394594 SPP1/CTSB/ICAM1/PSAP/ZFP36L1/RBPJ/ARRB2/JUNB/FOXO3/NRIP1/NUPR1/NCOA4/PTPN6/HIF1A/FEM1B/CITED2/STK4 17 GO:0043242 negative regulation of protein-containing complex disassembly 5/502 82/18722 0.0692769600420418 0.166968800613049 CAPG/CAPZA2/EPS8/GSN/TAOK1 5 GO:0042552 myelination 7/502 134/18722 0.0692996319016547 0.166968800613049 PMP22/CTSC/TNFRSF1B/TYMP/QKI/CYFIP1/ACER3 7 GO:0098727 maintenance of cell number 7/502 134/18722 0.0692996319016547 0.166968800613049 IGF1/RBPJ/SPI1/ZFP36L2/FOXO3/KLF4/STAT3 7 GO:0010574 regulation of vascular endothelial growth factor production 4/502 58/18722 0.0698466077921597 0.167936802311087 C3AR1/C5AR1/TGFB1/HIF1A 4 GO:0018208 peptidyl-proline modification 4/502 58/18722 0.0698466077921597 0.167936802311087 FKBP5/FKBP15/P4HA1/RANBP2 4 GO:0035904 aorta development 4/502 58/18722 0.0698466077921597 0.167936802311087 PLXND1/RBPJ/ENG/LRP1 4 GO:0042743 hydrogen peroxide metabolic process 4/502 58/18722 0.0698466077921597 0.167936802311087 CYBA/SOD2/GPX1/STAT3 4 GO:0006958 complement activation, classical pathway 6/502 108/18722 0.0705300461319751 0.169316031866381 C1QA/C1QB/C1QC/C2/CR1/SERPING1 6 GO:0007173 epidermal growth factor receptor signaling pathway 6/502 108/18722 0.0705300461319751 0.169316031866381 CCDC88A/IQGAP1/SNX6/TGFB1/NCF1/DUSP3 6 GO:0033138 positive regulation of peptidyl-serine phosphorylation 6/502 108/18722 0.0705300461319751 0.169316031866381 GAS6/ARRB2/CD44/TGFB1/CREBL2/STK4 6 GO:0006869 lipid transport 16/502 398/18722 0.0712137100231797 0.17052180484594 SPP1/PLTP/SLCO2B1/ATP8B4/APOE/CD36/MSR1/NPC2/PSAP/SYK/ABCA1/APOL6/PLSCR1/TSPO/LRP1/STX12 16 GO:0003203 endocardial cushion morphogenesis 3/502 36/18722 0.0713272140892552 0.17052180484594 RBPJ/TGFBR2/ENG 3 GO:0010762 regulation of fibroblast migration 3/502 36/18722 0.0713272140892552 0.17052180484594 ARHGAP4/SLC8A1/TGFB1 3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/502 36/18722 0.0713272140892552 0.17052180484594 HLA-DRB1/HIF1A/LRP1 3 GO:0045191 regulation of isotype switching 3/502 36/18722 0.0713272140892552 0.17052180484594 CD28/PTPRC/TGFB1 3 GO:0070670 response to interleukin-4 3/502 36/18722 0.0713272140892552 0.17052180484594 MRC1/PARP14/XBP1 3 GO:0090313 regulation of protein targeting to membrane 3/502 36/18722 0.0713272140892552 0.17052180484594 ITGB2/ITGAM/PRNP 3 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/502 36/18722 0.0713272140892552 0.17052180484594 CD74/CD44/SKIL 3 GO:0006401 RNA catabolic process 12/502 278/18722 0.0723268046313249 0.172732988241874 RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/ZFP36/HSPA1A/ATM/BTG2/VIM/ZFP36L2/DDX5 12 GO:0022898 regulation of transmembrane transporter activity 12/502 278/18722 0.0723268046313249 0.172732988241874 MEF2C/CCL2/ATP1B1/TMSB4X/CTSS/VMP1/PRNP/ACTB/IFNGR2/FXYD5/CAB39/CALM2 12 GO:0002064 epithelial cell development 10/502 220/18722 0.0732033523037896 0.17461375366476 ICAM1/PECAM1/IQGAP1/VIM/GPX1/TNFRSF1A/MSN/HIF1A/FEM1B/SLC4A7 10 GO:0033013 tetrapyrrole metabolic process 4/502 59/18722 0.0734162885598699 0.17461375366476 SLCO2B1/BLVRB/SLC11A2/TSPO 4 GO:0043407 negative regulation of MAP kinase activity 4/502 59/18722 0.0734162885598699 0.17461375366476 APOE/LYN/DUSP1/PTPN6 4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 4/502 59/18722 0.0734162885598699 0.17461375366476 LYN/KLF4/TGFB1/PIK3R1 4 GO:0046324 regulation of glucose import 4/502 59/18722 0.0734162885598699 0.17461375366476 IGF1/MEF2A/CREBL2/PIK3R1 4 GO:0048278 vesicle docking 4/502 59/18722 0.0734162885598699 0.17461375366476 PLEK/STX7/STX12/RAB8B 4 GO:0051353 positive regulation of oxidoreductase activity 4/502 59/18722 0.0734162885598699 0.17461375366476 APOE/CYBA/GNAI2/HIF1A 4 GO:2000351 regulation of endothelial cell apoptotic process 4/502 59/18722 0.0734162885598699 0.17461375366476 CCL2/GAS6/ICAM1/FOXO3 4 GO:0007272 ensheathment of neurons 7/502 136/18722 0.0737306913651837 0.175091467276869 PMP22/CTSC/TNFRSF1B/TYMP/QKI/CYFIP1/ACER3 7 GO:0008366 axon ensheathment 7/502 136/18722 0.0737306913651837 0.175091467276869 PMP22/CTSC/TNFRSF1B/TYMP/QKI/CYFIP1/ACER3 7 GO:1900180 regulation of protein localization to nucleus 7/502 136/18722 0.0737306913651837 0.175091467276869 CD36/PARP9/JAK2/GLUL/DTX3L/TGFB1/PIK3R1 7 GO:0050806 positive regulation of synaptic transmission 8/502 164/18722 0.0747454878812083 0.175689315478912 CCL2/TYROBP/LGMN/APOE/ARRB2/PRNP/GLUL/SLC1A3 8 GO:0001829 trophectodermal cell differentiation 2/502 17/18722 0.0748559534822601 0.175689315478912 JUNB/CITED2 2 GO:0006390 mitochondrial transcription 2/502 17/18722 0.0748559534822601 0.175689315478912 FOXO3/CHCHD10 2 GO:0006895 Golgi to endosome transport 2/502 17/18722 0.0748559534822601 0.175689315478912 VPS13C/EPS15 2 GO:0009084 glutamine family amino acid biosynthetic process 2/502 17/18722 0.0748559534822601 0.175689315478912 GLUL/GLS 2 GO:0009251 glucan catabolic process 2/502 17/18722 0.0748559534822601 0.175689315478912 PYGL/GAA 2 GO:0014856 skeletal muscle cell proliferation 2/502 17/18722 0.0748559534822601 0.175689315478912 JAK2/STAT3 2 GO:0020027 hemoglobin metabolic process 2/502 17/18722 0.0748559534822601 0.175689315478912 KLF4/HIF1A 2 GO:0032604 granulocyte macrophage colony-stimulating factor production 2/502 17/18722 0.0748559534822601 0.175689315478912 CD84/SYK 2 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 2/502 17/18722 0.0748559534822601 0.175689315478912 CD84/SYK 2 GO:0033623 regulation of integrin activation 2/502 17/18722 0.0748559534822601 0.175689315478912 PLEK/PTGER4 2 GO:0035729 cellular response to hepatocyte growth factor stimulus 2/502 17/18722 0.0748559534822601 0.175689315478912 LGMN/NRP1 2 GO:0035855 megakaryocyte development 2/502 17/18722 0.0748559534822601 0.175689315478912 PTPN6/ABI1 2 GO:0036035 osteoclast development 2/502 17/18722 0.0748559534822601 0.175689315478912 TYROBP/ATP6AP1 2 GO:0038065 collagen-activated signaling pathway 2/502 17/18722 0.0748559534822601 0.175689315478912 SYK/JAK2 2 GO:0043117 positive regulation of vascular permeability 2/502 17/18722 0.0748559534822601 0.175689315478912 APOE/TGFB1 2 GO:0060977 coronary vasculature morphogenesis 2/502 17/18722 0.0748559534822601 0.175689315478912 SPRED1/NRP1 2 GO:0061298 retina vasculature development in camera-type eye 2/502 17/18722 0.0748559534822601 0.175689315478912 NRP1/HIF1A 2 GO:0061450 trophoblast cell migration 2/502 17/18722 0.0748559534822601 0.175689315478912 ARHGDIB/TIMP1 2 GO:0070206 protein trimerization 2/502 17/18722 0.0748559534822601 0.175689315478912 CD74/ALOX5AP 2 GO:0097067 cellular response to thyroid hormone stimulus 2/502 17/18722 0.0748559534822601 0.175689315478912 CTSS/CTSB 2 GO:1904262 negative regulation of TORC1 signaling 2/502 17/18722 0.0748559534822601 0.175689315478912 ATM/SESN1 2 GO:2000811 negative regulation of anoikis 2/502 17/18722 0.0748559534822601 0.175689315478912 PDK4/MCL1 2 GO:0006970 response to osmotic stress 5/502 84/18722 0.0751447025867078 0.176009819830942 ZFP36L1/HNMT/TSC22D3/TSPO/CAB39 5 GO:0032370 positive regulation of lipid transport 5/502 84/18722 0.0751447025867078 0.176009819830942 SPP1/PLTP/APOE/ABCA1/LRP1 5 GO:0042440 pigment metabolic process 5/502 84/18722 0.0751447025867078 0.176009819830942 SLCO2B1/ZEB2/BLVRB/SLC11A2/TSPO 5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 5/502 84/18722 0.0751447025867078 0.176009819830942 CCL2/GPNMB/RB1/ATM/KLF4 5 GO:0021700 developmental maturation 12/502 280/18722 0.0753801801824564 0.176472021014192 C1QA/IGF1/RB1/RBPJ/NR4A2/KLF2/CLEC7A/CD63/FOXO3/ATP6AP2/HIF1A/FEM1B 12 GO:0032409 regulation of transporter activity 13/502 310/18722 0.0755148739129459 0.176697929550474 MEF2C/CCL2/ATP1B1/TMSB4X/CTSS/VMP1/PRNP/ACTB/IFNGR2/SGK1/FXYD5/CAB39/CALM2 13 GO:0009408 response to heat 6/502 110/18722 0.0756020456604491 0.176812468769079 CD14/IGF1/TFEC/HSPA1A/LYN/ATM 6 GO:0001990 regulation of systemic arterial blood pressure by hormone 3/502 37/18722 0.0761416203531126 0.177357067348187 CTSZ/CYBA/ATP6AP2 3 GO:0032885 regulation of polysaccharide biosynthetic process 3/502 37/18722 0.0761416203531126 0.177357067348187 IGF1/CLTC/TGFB1 3 GO:0033120 positive regulation of RNA splicing 3/502 37/18722 0.0761416203531126 0.177357067348187 HSPA1A/SETX/PIK3R1 3 GO:0043029 T cell homeostasis 3/502 37/18722 0.0761416203531126 0.177357067348187 NCKAP1L/LGALS9/TSC22D3 3 GO:0043368 positive T cell selection 3/502 37/18722 0.0761416203531126 0.177357067348187 CD74/PTPRC/STAT3 3 GO:0048009 insulin-like growth factor receptor signaling pathway 3/502 37/18722 0.0761416203531126 0.177357067348187 IGF1/IGFBP4/PIK3R1 3 GO:0090218 positive regulation of lipid kinase activity 3/502 37/18722 0.0761416203531126 0.177357067348187 LYN/CD81/TGFB1 3 GO:1900016 negative regulation of cytokine production involved in inflammatory response 3/502 37/18722 0.0761416203531126 0.177357067348187 SIRPA/PYCARD/ADCY7 3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 4/502 60/18722 0.077076846709285 0.178994725339936 CELF2/MBNL1/DDX17/DDX5 4 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 4/502 60/18722 0.077076846709285 0.178994725339936 TLR4/HSPA1A/SLC15A3/IFIH1 4 GO:0009620 response to fungus 4/502 60/18722 0.077076846709285 0.178994725339936 TLR4/SPI1/SYK/CLEC7A 4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 4/502 60/18722 0.077076846709285 0.178994725339936 ATM/NABP1/TAOK3/TAOK1 4 GO:0042306 regulation of protein import into nucleus 4/502 60/18722 0.077076846709285 0.178994725339936 CD36/JAK2/TGFB1/PIK3R1 4 GO:1903670 regulation of sprouting angiogenesis 4/502 60/18722 0.077076846709285 0.178994725339936 KLF2/ALOX5/GLUL/KLF4 4 GO:0090257 regulation of muscle system process 11/502 252/18722 0.0779838291258072 0.1810101322308 IGF1/ATP1B1/AIF1/TNFRSF1B/MEF2A/SLC8A1/FOXO3/TNFRSF1A/KLF4/NR4A1/CALM2 11 GO:0001938 positive regulation of endothelial cell proliferation 6/502 111/18722 0.0782137968157642 0.181452870646803 EGFL7/CYBA/NRP1/NR4A1/STAT3/HIF1A 6 GO:0070588 calcium ion transmembrane transport 13/502 312/18722 0.0784859846828309 0.181993065234474 ATP1B1/GAS6/CCL3/CYBA/PTPRC/VMP1/MCOLN1/ITPR2/PRNP/SLC8A1/LYN/PTPN6/CALM2 13 GO:0019439 aromatic compound catabolic process 18/502 467/18722 0.0797095451072756 0.184737653139407 SLCO2B1/RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/SAMHD1/ZFP36/TYMP/HSPA1A/BLVRB/HNMT/ATM/BTG2/VIM/ZFP36L2/DDX5/MGAT1 18 GO:0032984 protein-containing complex disassembly 10/502 224/18722 0.0803045512219304 0.186023462169579 PLEK/VMP1/MCOLN1/LAMP2/SETX/CAPG/CAPZA2/EPS8/GSN/TAOK1 10 GO:0030216 keratinocyte differentiation 7/502 139/18722 0.0806838983030301 0.186808665440349 TXNIP/ZFP36L1/RBPJ/ZFP36/ADAM9/ASAH1/STK4 7 GO:0030865 cortical cytoskeleton organization 4/502 61/18722 0.0808272417267973 0.186878973566319 PLEK/NCKAP1L/LCP1/RHOB 4 GO:0060998 regulation of dendritic spine development 4/502 61/18722 0.0808272417267973 0.186878973566319 MEF2C/APOE/ITSN1/ACTR2 4 GO:0000956 nuclear-transcribed mRNA catabolic process 6/502 112/18722 0.0808758549675251 0.186878973566319 ZFP36L1/ZFP36/ATM/BTG2/ZFP36L2/DDX5 6 GO:0010633 negative regulation of epithelial cell migration 6/502 112/18722 0.0808758549675251 0.186878973566319 MEF2C/SPRED1/APOE/KLF4/TGFB1/SP100 6 GO:0046329 negative regulation of JNK cascade 3/502 38/18722 0.081095215392123 0.187012196612144 SIRPA/DUSP3/TAOK3 3 GO:0072538 T-helper 17 type immune response 3/502 38/18722 0.081095215392123 0.187012196612144 CLEC7A/STAT3/NFKBIZ 3 GO:1901031 regulation of response to reactive oxygen species 3/502 38/18722 0.081095215392123 0.187012196612144 CD36/FOXO3/SESN1 3 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 3/502 38/18722 0.081095215392123 0.187012196612144 HSPA1A/CHCHD10/BNIP3L 3 GO:1903510 mucopolysaccharide metabolic process 5/502 86/18722 0.0812734795104009 0.187329903445498 CLTC/CD44/TGFB1/GNS/DSE 5 GO:0010001 glial cell differentiation 10/502 225/18722 0.0821439530239478 0.189077369520342 C1QA/TLR4/TNFRSF1B/C5AR1/GRN/LYN/VIM/TGFB1/STAT3/LRP1 10 GO:0031032 actomyosin structure organization 9/502 196/18722 0.0821542396748567 0.189077369520342 CCDC88A/PTGER4/MEF2A/NRP1/GPR65/WAS/PIK3R1/PRKAR1A/AKAP13 9 GO:0090276 regulation of peptide hormone secretion 9/502 196/18722 0.0821542396748567 0.189077369520342 HLA-DRB1/ITSN1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 9 GO:0003128 heart field specification 2/502 18/18722 0.0827647989761056 0.189539584189834 MEF2C/RBPJ 2 GO:0021534 cell proliferation in hindbrain 2/502 18/18722 0.0827647989761056 0.189539584189834 C5AR1/ATF5 2 GO:0030728 ovulation 2/502 18/18722 0.0827647989761056 0.189539584189834 FOXO3/NRIP1 2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 2/502 18/18722 0.0827647989761056 0.189539584189834 RSAD2/CD81 2 GO:0042693 muscle cell fate commitment 2/502 18/18722 0.0827647989761056 0.189539584189834 MEF2C/RBPJ 2 GO:0044247 cellular polysaccharide catabolic process 2/502 18/18722 0.0827647989761056 0.189539584189834 PYGL/GAA 2 GO:0060716 labyrinthine layer blood vessel development 2/502 18/18722 0.0827647989761056 0.189539584189834 RBPJ/JUNB 2 GO:1900006 positive regulation of dendrite development 2/502 18/18722 0.0827647989761056 0.189539584189834 IQGAP1/CYFIP1 2 GO:1900225 regulation of NLRP3 inflammasome complex assembly 2/502 18/18722 0.0827647989761056 0.189539584189834 CD36/TLR4 2 GO:1905820 positive regulation of chromosome separation 2/502 18/18722 0.0827647989761056 0.189539584189834 RB1/PLSCR1 2 GO:0015748 organophosphate ester transport 7/502 140/18722 0.0830832040903459 0.190174617576418 PLTP/CR1/ATP8B4/APOE/NPC2/ABCA1/PLSCR1 7 GO:1902806 regulation of cell cycle G1/S phase transition 8/502 168/18722 0.0832391529775243 0.190437349987155 CCL2/AIF1/GPNMB/RB1/ATM/KLF4/PTPN6/KMT2E 8 GO:0019915 lipid storage 5/502 87/18722 0.0844347547743075 0.192981806119539 APOE/CD36/MSR1/ABCA1/NRIP1 5 GO:1900182 positive regulation of protein localization to nucleus 5/502 87/18722 0.0844347547743075 0.192981806119539 PARP9/JAK2/DTX3L/TGFB1/PIK3R1 5 GO:0010573 vascular endothelial growth factor production 4/502 62/18722 0.0846663602894716 0.193034294085311 C3AR1/C5AR1/TGFB1/HIF1A 4 GO:0046173 polyol biosynthetic process 4/502 62/18722 0.0846663602894716 0.193034294085311 PLEK/ASAH1/SPTLC2/ACER3 4 GO:0046824 positive regulation of nucleocytoplasmic transport 4/502 62/18722 0.0846663602894716 0.193034294085311 GAS6/JAK2/TGFB1/PIK3R1 4 GO:0048488 synaptic vesicle endocytosis 4/502 62/18722 0.0846663602894716 0.193034294085311 ITSN1/ACTB/ITSN2/FCHO2 4 GO:0140238 presynaptic endocytosis 4/502 62/18722 0.0846663602894716 0.193034294085311 ITSN1/ACTB/ITSN2/FCHO2 4 GO:0035296 regulation of tube diameter 7/502 141/18722 0.0855231652984022 0.194795747252786 APOE/ICAM1/TBXAS1/KLF2/SLC8A1/SOD2/GPX1 7 GO:0097746 blood vessel diameter maintenance 7/502 141/18722 0.0855231652984022 0.194795747252786 APOE/ICAM1/TBXAS1/KLF2/SLC8A1/SOD2/GPX1 7 GO:0042417 dopamine metabolic process 3/502 39/18722 0.0861843629393522 0.195915903173191 ITGB2/ITGAM/NR4A2 3 GO:0046621 negative regulation of organ growth 3/502 39/18722 0.0861843629393522 0.195915903173191 TGFBR2/CITED2/STK4 3 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 3/502 39/18722 0.0861843629393522 0.195915903173191 ATP1B1/VMP1/CALM2 3 GO:1902742 apoptotic process involved in development 3/502 39/18722 0.0861843629393522 0.195915903173191 TNFRSF1B/SPI1/TNFRSF1A 3 GO:0046660 female sex differentiation 6/502 114/18722 0.0863501582225134 0.196100064770421 ICAM1/ARRB2/LHFPL2/FOXO3/NRIP1/NUPR1 6 GO:0051261 protein depolymerization 6/502 114/18722 0.0863501582225134 0.196100064770421 PLEK/CAPG/CAPZA2/EPS8/GSN/TAOK1 6 GO:0043087 regulation of GTPase activity 14/502 348/18722 0.0868990905155229 0.19724984922709 CCL2/CCL3/ADAP2/PLXND1/ICAM1/CCL4/RGS1/ARRB2/PREX1/PYCARD/IQGAP1/RGS10/GPR65/PLXNB2 14 GO:0009144 purine nucleoside triphosphate metabolic process 5/502 88/18722 0.0876600054420792 0.198754529345156 TMSB4X/SAMHD1/TGFB1/GIMAP7/STAT3 5 GO:0050779 RNA destabilization 5/502 88/18722 0.0876600054420792 0.198754529345156 TNFRSF1B/ZFP36L1/ZFP36/BTG2/ZFP36L2 5 GO:0030178 negative regulation of Wnt signaling pathway 8/502 170/18722 0.0876908764361141 0.198754529345156 IGFBP4/APOE/DAB2/RNF213/EGR1/FOXO3/LRP1/STK4 8 GO:0035150 regulation of tube size 7/502 142/18722 0.0880036794499172 0.199365828175963 APOE/ICAM1/TBXAS1/KLF2/SLC8A1/SOD2/GPX1 7 GO:0016239 positive regulation of macroautophagy 4/502 63/18722 0.0885930197103192 0.200308557761455 SPTLC2/HIF1A/SESN1/BNIP3L 4 GO:0046902 regulation of mitochondrial membrane permeability 4/502 63/18722 0.0885930197103192 0.200308557761455 HSPA1A/STAT3/CHCHD10/BNIP3L 4 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 4/502 63/18722 0.0885930197103192 0.200308557761455 HSPA1A/XBP1/TMBIM6/HERPUD1 4 GO:1904589 regulation of protein import 4/502 63/18722 0.0885930197103192 0.200308557761455 CD36/JAK2/TGFB1/PIK3R1 4 GO:0048469 cell maturation 8/502 171/18722 0.0899678149403718 0.202881258886218 C1QA/RB1/NR4A2/KLF2/CLEC7A/FOXO3/HIF1A/FEM1B 8 GO:0002523 leukocyte migration involved in inflammatory response 2/502 19/18722 0.0909150128990771 0.202881258886218 NINJ1/ALOX5 2 GO:0002902 regulation of B cell apoptotic process 2/502 19/18722 0.0909150128990771 0.202881258886218 CD74/LYN 2 GO:0003085 negative regulation of systemic arterial blood pressure 2/502 19/18722 0.0909150128990771 0.202881258886218 SOD2/PRCP 2 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 2/502 19/18722 0.0909150128990771 0.202881258886218 RGS10/GNAI2 2 GO:0010744 positive regulation of macrophage derived foam cell differentiation 2/502 19/18722 0.0909150128990771 0.202881258886218 CD36/MSR1 2 GO:0030050 vesicle transport along actin filament 2/502 19/18722 0.0909150128990771 0.202881258886218 MYO5A/MYO1F 2 GO:0030220 platelet formation 2/502 19/18722 0.0909150128990771 0.202881258886218 MEF2C/PTPN6 2 GO:0032011 ARF protein signal transduction 2/502 19/18722 0.0909150128990771 0.202881258886218 CYTH4/CYTH1 2 GO:0032012 regulation of ARF protein signal transduction 2/502 19/18722 0.0909150128990771 0.202881258886218 CYTH4/CYTH1 2 GO:0032616 interleukin-13 production 2/502 19/18722 0.0909150128990771 0.202881258886218 LGALS9/HLA-E 2 GO:0032656 regulation of interleukin-13 production 2/502 19/18722 0.0909150128990771 0.202881258886218 LGALS9/HLA-E 2 GO:0035728 response to hepatocyte growth factor 2/502 19/18722 0.0909150128990771 0.202881258886218 LGMN/NRP1 2 GO:0036344 platelet morphogenesis 2/502 19/18722 0.0909150128990771 0.202881258886218 MEF2C/PTPN6 2 GO:0044003 modulation by symbiont of host process 2/502 19/18722 0.0909150128990771 0.202881258886218 CD4/ATG7 2 GO:0044546 NLRP3 inflammasome complex assembly 2/502 19/18722 0.0909150128990771 0.202881258886218 CD36/TLR4 2 GO:0045821 positive regulation of glycolytic process 2/502 19/18722 0.0909150128990771 0.202881258886218 IGF1/HIF1A 2 GO:0046716 muscle cell cellular homeostasis 2/502 19/18722 0.0909150128990771 0.202881258886218 HIF1A/GAA 2 GO:0046782 regulation of viral transcription 2/502 19/18722 0.0909150128990771 0.202881258886218 IFITM3/ZFP36 2 GO:0060216 definitive hemopoiesis 2/502 19/18722 0.0909150128990771 0.202881258886218 ZFP36L2/ADAR 2 GO:0061760 antifungal innate immune response 2/502 19/18722 0.0909150128990771 0.202881258886218 SPI1/CLEC7A 2 GO:0070233 negative regulation of T cell apoptotic process 2/502 19/18722 0.0909150128990771 0.202881258886218 TSC22D3/HIF1A 2 GO:1900221 regulation of amyloid-beta clearance 2/502 19/18722 0.0909150128990771 0.202881258886218 APOE/LRP1 2 GO:1901739 regulation of myoblast fusion 2/502 19/18722 0.0909150128990771 0.202881258886218 CD53/PLEKHO1 2 GO:1903204 negative regulation of oxidative stress-induced neuron death 2/502 19/18722 0.0909150128990771 0.202881258886218 ATG7/HIF1A 2 GO:1903975 regulation of glial cell migration 2/502 19/18722 0.0909150128990771 0.202881258886218 CCL3/LRP1 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/502 19/18722 0.0909150128990771 0.202881258886218 DAB2/BMP2K 2 GO:0030866 cortical actin cytoskeleton organization 3/502 40/18722 0.091405327367129 0.203093681268174 PLEK/NCKAP1L/LCP1 3 GO:0045022 early endosome to late endosome transport 3/502 40/18722 0.091405327367129 0.203093681268174 DAB2/MSN/DNAJC13 3 GO:0060412 ventricular septum morphogenesis 3/502 40/18722 0.091405327367129 0.203093681268174 RBPJ/TGFBR2/CITED2 3 GO:0071526 semaphorin-plexin signaling pathway 3/502 40/18722 0.091405327367129 0.203093681268174 PLXND1/NRP1/PLXNB2 3 GO:0097352 autophagosome maturation 3/502 40/18722 0.091405327367129 0.203093681268174 VMP1/MCOLN1/LAMP2 3 GO:1901223 negative regulation of NIK/NF-kappaB signaling 3/502 40/18722 0.091405327367129 0.203093681268174 TMSB4X/SPI1/LITAF 3 GO:1901998 toxin transport 3/502 40/18722 0.091405327367129 0.203093681268174 NRP1/ATP6V0A1/ADAM10 3 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 3/502 40/18722 0.091405327367129 0.203093681268174 HSPA1A/CHCHD10/BNIP3L 3 GO:2000142 regulation of DNA-templated transcription, initiation 3/502 40/18722 0.091405327367129 0.203093681268174 SETX/JUN/ATF7IP 3 GO:0033559 unsaturated fatty acid metabolic process 6/502 116/18722 0.0920232392535577 0.20436846125154 HPGDS/CD74/TBXAS1/ALOX5/GPX1/TNFRSF1A 6 GO:0007219 Notch signaling pathway 8/502 172/18722 0.0922787185783673 0.204837501028564 EGFL7/CFD/BMP2K/RBPJ/TGFBR2/DTX3L/STAT3/ADAM10 8 GO:0046579 positive regulation of Ras protein signal transduction 4/502 64/18722 0.0926059713598778 0.205268434839863 LPAR6/IGF1/GPR65/AKAP13 4 GO:0050771 negative regulation of axonogenesis 4/502 64/18722 0.0926059713598778 0.205268434839863 SPP1/ARHGAP4/NRP1/RTN4 4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 4/502 64/18722 0.0926059713598778 0.205268434839863 HLA-DRB1/UCP2/HIF1A/LRP1 4 GO:0007612 learning 7/502 144/18722 0.0930858755101947 0.206233362121724 LGMN/FOS/BTG2/ACTR2/PPT1/HIF1A/JUN 7 GO:0009913 epidermal cell differentiation 9/502 202/18722 0.0946587300224204 0.209617656813651 TXNIP/ZFP36L1/RBPJ/ZFP36/ADAM9/ASAH1/KLF4/SLC4A7/STK4 9 GO:1903828 negative regulation of cellular protein localization 6/502 117/18722 0.0949336785834093 0.210125931639642 DAB2/CD36/SPI1/CLTC/TGFB1/SP100 6 GO:0010876 lipid localization 17/502 448/18722 0.0963864008900989 0.213135871664198 SPP1/PLTP/SLCO2B1/ATP8B4/APOE/CD36/MSR1/NPC2/PSAP/SYK/ABCA1/APOL6/PLSCR1/TSPO/NRIP1/LRP1/STX12 17 GO:0046513 ceramide biosynthetic process 4/502 65/18722 0.0967039040580068 0.213135871664198 ASAH1/SGMS1/ST8SIA4/SPTLC2 4 GO:0048645 animal organ formation 4/502 65/18722 0.0967039040580068 0.213135871664198 MEF2C/RBPJ/TGFBR2/CITED2 4 GO:0072577 endothelial cell apoptotic process 4/502 65/18722 0.0967039040580068 0.213135871664198 CCL2/GAS6/ICAM1/FOXO3 4 GO:0042307 positive regulation of protein import into nucleus 3/502 41/18722 0.0967542867476906 0.213135871664198 JAK2/TGFB1/PIK3R1 3 GO:0055023 positive regulation of cardiac muscle tissue growth 3/502 41/18722 0.0967542867476906 0.213135871664198 MEF2C/IGF1/RBPJ 3 GO:0060612 adipose tissue development 3/502 41/18722 0.0967542867476906 0.213135871664198 SPI1/XBP1/SPTLC2 3 GO:0070296 sarcoplasmic reticulum calcium ion transport 3/502 41/18722 0.0967542867476906 0.213135871664198 CCL3/SLC8A1/CALM2 3 GO:0071470 cellular response to osmotic stress 3/502 41/18722 0.0967542867476906 0.213135871664198 ZFP36L1/TSPO/CAB39 3 GO:1900371 regulation of purine nucleotide biosynthetic process 3/502 41/18722 0.0967542867476906 0.213135871664198 TMSB4X/PDK4/STAT3 3 GO:0060191 regulation of lipase activity 5/502 91/18722 0.0977143079333941 0.215148209662009 CD86/C5AR1/PPT1/LRP1/GNA13 5 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 7/502 146/18722 0.0983286500243064 0.216294976230357 PTGER4/ABCA1/GPR65/ADCY7/GNAI2/GNA13/AKAP13 7 GO:0010675 regulation of cellular carbohydrate metabolic process 7/502 146/18722 0.0983286500243064 0.216294976230357 IGF1/IGFBP4/PLEK/PDK4/NUPR1/STAT3/RANBP2 7 GO:0000272 polysaccharide catabolic process 2/502 20/18722 0.0992880265473841 0.217063521175897 PYGL/GAA 2 GO:0003159 morphogenesis of an endothelium 2/502 20/18722 0.0992880265473841 0.217063521175897 RBPJ/RHOB 2 GO:0006700 C21-steroid hormone biosynthetic process 2/502 20/18722 0.0992880265473841 0.217063521175897 EGR1/TSPO 2 GO:0006896 Golgi to vacuole transport 2/502 20/18722 0.0992880265473841 0.217063521175897 LAPTM5/LAMP1 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/502 20/18722 0.0992880265473841 0.217063521175897 TMBIM6/CALM2 2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 2/502 20/18722 0.0992880265473841 0.217063521175897 SPRED1/CALM2 2 GO:0043691 reverse cholesterol transport 2/502 20/18722 0.0992880265473841 0.217063521175897 APOE/ABCA1 2 GO:0046931 pore complex assembly 2/502 20/18722 0.0992880265473841 0.217063521175897 RTN4/ADAM10 2 GO:0048670 regulation of collateral sprouting 2/502 20/18722 0.0992880265473841 0.217063521175897 SPP1/LRP1 2 GO:0060044 negative regulation of cardiac muscle cell proliferation 2/502 20/18722 0.0992880265473841 0.217063521175897 TGFBR2/CITED2 2 GO:0060252 positive regulation of glial cell proliferation 2/502 20/18722 0.0992880265473841 0.217063521175897 LYN/TSPO 2 GO:0061154 endothelial tube morphogenesis 2/502 20/18722 0.0992880265473841 0.217063521175897 RBPJ/RHOB 2 GO:0140632 inflammasome complex assembly 2/502 20/18722 0.0992880265473841 0.217063521175897 CD36/TLR4 2 GO:0014015 positive regulation of gliogenesis 4/502 66/18722 0.100885447430334 0.220347535322345 TNFRSF1B/LYN/TSPO/TGFB1 4 GO:0050918 positive chemotaxis 4/502 66/18722 0.100885447430334 0.220347535322345 CCL3/GPNMB/NRP1/LRP1 4 GO:0000413 protein peptidyl-prolyl isomerization 3/502 42/18722 0.10222734515168 0.222099329331306 FKBP5/FKBP15/RANBP2 3 GO:0007520 myoblast fusion 3/502 42/18722 0.10222734515168 0.222099329331306 CD53/PLEKHO1/CD81 3 GO:0010677 negative regulation of cellular carbohydrate metabolic process 3/502 42/18722 0.10222734515168 0.222099329331306 PLEK/NUPR1/STAT3 3 GO:0010939 regulation of necrotic cell death 3/502 42/18722 0.10222734515168 0.222099329331306 ASAH1/TSPO/NUPR1 3 GO:0016601 Rac protein signal transduction 3/502 42/18722 0.10222734515168 0.222099329331306 AIF1/CYFIP1/EPS8 3 GO:0030808 regulation of nucleotide biosynthetic process 3/502 42/18722 0.10222734515168 0.222099329331306 TMSB4X/PDK4/STAT3 3 GO:0032691 negative regulation of interleukin-1 beta production 3/502 42/18722 0.10222734515168 0.222099329331306 IGF1/ARRB2/ACP5 3 GO:0035019 somatic stem cell population maintenance 3/502 42/18722 0.10222734515168 0.222099329331306 RBPJ/SPI1/ZFP36L2 3 GO:0045047 protein targeting to ER 3/502 42/18722 0.10222734515168 0.222099329331306 MAN1A1/TRAM1/HERPUD1 3 GO:0060999 positive regulation of dendritic spine development 3/502 42/18722 0.10222734515168 0.222099329331306 APOE/ITSN1/ACTR2 3 GO:0072595 maintenance of protein localization in organelle 3/502 42/18722 0.10222734515168 0.222099329331306 TSPO/SP100/CHCHD10 3 GO:0003012 muscle system process 17/502 452/18722 0.102263634127903 0.222099329331306 IGF1/ATP1B1/GATM/AIF1/CYBA/TNFRSF1B/MEF2A/SLC8A1/FOXO3/TNFRSF1A/KLF4/NR4A1/TPM3/GAA/CALM2/GSN/AKAP13 17 GO:0007589 body fluid secretion 5/502 93/18722 0.104726683837212 0.227022324007003 CYBA/OAS2/XBP1/HIF1A/USF2 5 GO:0033273 response to vitamin 5/502 93/18722 0.104726683837212 0.227022324007003 SPP1/FOLR2/GAS6/SOD2/TSPO 5 GO:0060349 bone morphogenesis 5/502 93/18722 0.104726683837212 0.227022324007003 MEF2C/TGFBR2/ACP5/DHRS3/CITED2 5 GO:1902807 negative regulation of cell cycle G1/S phase transition 5/502 93/18722 0.104726683837212 0.227022324007003 CCL2/GPNMB/RB1/ATM/KLF4 5 GO:0030111 regulation of Wnt signaling pathway 13/502 328/18722 0.104931934104181 0.227360715300207 ZEB2/IGFBP4/APOE/DAB2/RBPJ/RNF213/EGR1/FOXO3/TGFB1/ATP6AP2/LRP1/MACF1/STK4 13 GO:0016445 somatic diversification of immunoglobulins 4/502 67/18722 0.105149175224288 0.227618195876254 CD28/PTPRC/SAMHD1/TGFB1 4 GO:1902117 positive regulation of organelle assembly 4/502 67/18722 0.105149175224288 0.227618195876254 CCDC88A/LCP1/SDCBP/MSN 4 GO:0032412 regulation of ion transmembrane transporter activity 11/502 267/18722 0.105719863397348 0.228746533244216 MEF2C/CCL2/ATP1B1/TMSB4X/CTSS/VMP1/PRNP/IFNGR2/FXYD5/CAB39/CALM2 11 GO:0032368 regulation of lipid transport 7/502 149/18722 0.106490778435475 0.230306844807157 SPP1/PLTP/APOE/SYK/ABCA1/TSPO/LRP1 7 GO:0048511 rhythmic process 12/502 298/18722 0.106542692029529 0.230311445480654 ARRB2/NAMPT/EGR1/ATG7/FOXO3/NRIP1/SETX/DDX5/AHR/ZFHX3/JUN/ATF5 12 GO:0001838 embryonic epithelial tube formation 6/502 121/18722 0.107060863140461 0.230479691476135 TGFB1/PRKACB/HIF1A/CITED2/STK4/PLXNB2 6 GO:0001709 cell fate determination 3/502 43/18722 0.107820544219404 0.230479691476135 MEF2C/KLF4/MCL1 3 GO:0030517 negative regulation of axon extension 3/502 43/18722 0.107820544219404 0.230479691476135 ARHGAP4/NRP1/RTN4 3 GO:0033173 calcineurin-NFAT signaling cascade 3/502 43/18722 0.107820544219404 0.230479691476135 IGF1/PRNP/CLEC7A 3 GO:0035794 positive regulation of mitochondrial membrane permeability 3/502 43/18722 0.107820544219404 0.230479691476135 HSPA1A/CHCHD10/BNIP3L 3 GO:0042088 T-helper 1 type immune response 3/502 43/18722 0.107820544219404 0.230479691476135 TLR4/HLA-DRB1/HAVCR2 3 GO:0045840 positive regulation of mitotic nuclear division 3/502 43/18722 0.107820544219404 0.230479691476135 IGF1/CD28/RB1 3 GO:0046636 negative regulation of alpha-beta T cell activation 3/502 43/18722 0.107820544219404 0.230479691476135 RUNX1/LGALS9/TNFRSF14 3 GO:0098927 vesicle-mediated transport between endosomal compartments 3/502 43/18722 0.107820544219404 0.230479691476135 DAB2/MSN/DNAJC13 3 GO:1904591 positive regulation of protein import 3/502 43/18722 0.107820544219404 0.230479691476135 JAK2/TGFB1/PIK3R1 3 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 3/502 43/18722 0.107820544219404 0.230479691476135 MEF2C/SOD2/GNA13 3 GO:0000002 mitochondrial genome maintenance 2/502 21/18722 0.10786608993641 0.230479691476135 TYMP/MEF2A 2 GO:0002689 negative regulation of leukocyte chemotaxis 2/502 21/18722 0.10786608993641 0.230479691476135 CCL2/DUSP1 2 GO:0043576 regulation of respiratory gaseous exchange 2/502 21/18722 0.10786608993641 0.230479691476135 NR4A2/GLS 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/502 21/18722 0.10786608993641 0.230479691476135 CD36/SP100 2 GO:0046885 regulation of hormone biosynthetic process 2/502 21/18722 0.10786608993641 0.230479691476135 EGR1/HIF1A 2 GO:0050849 negative regulation of calcium-mediated signaling 2/502 21/18722 0.10786608993641 0.230479691476135 PLEK/PRNP 2 GO:0051152 positive regulation of smooth muscle cell differentiation 2/502 21/18722 0.10786608993641 0.230479691476135 SOD2/ENG 2 GO:0060445 branching involved in salivary gland morphogenesis 2/502 21/18722 0.10786608993641 0.230479691476135 PLXND1/NRP1 2 GO:0072111 cell proliferation involved in kidney development 2/502 21/18722 0.10786608993641 0.230479691476135 EGR1/STAT1 2 GO:0098719 sodium ion import across plasma membrane 2/502 21/18722 0.10786608993641 0.230479691476135 SLC9A9/SLC8A1 2 GO:0099515 actin filament-based transport 2/502 21/18722 0.10786608993641 0.230479691476135 MYO5A/MYO1F 2 GO:0150105 protein localization to cell-cell junction 2/502 21/18722 0.10786608993641 0.230479691476135 PECAM1/ACTB 2 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/502 21/18722 0.10786608993641 0.230479691476135 HSPA1A/CHCHD10 2 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/502 21/18722 0.10786608993641 0.230479691476135 CD74/CD44 2 GO:0014020 primary neural tube formation 5/502 94/18722 0.108323753304935 0.231350730742674 TGFB1/PRKACB/HIF1A/CITED2/PLXNB2 5 GO:0042698 ovulation cycle 4/502 68/18722 0.109493608580101 0.233741316701222 ARRB2/EGR1/FOXO3/NRIP1 4 GO:0008585 female gonad development 5/502 95/18722 0.111980456387996 0.238939848362947 ICAM1/ARRB2/FOXO3/NRIP1/NUPR1 5 GO:1904064 positive regulation of cation transmembrane transport 7/502 151/18722 0.112128361400353 0.239145135932703 CCL2/ATP1B1/TMSB4X/CTSS/VMP1/IFNGR2/CALM2 7 GO:0034765 regulation of ion transmembrane transport 18/502 491/18722 0.112893526988601 0.240666108686298 CYBB/MEF2C/CCL2/SCN9A/ATP1B1/TMSB4X/CTSS/CYBA/VMP1/PRNP/SLC8A1/LYN/CD63/IFNGR2/FXYD5/PTPN6/CAB39/CALM2 18 GO:0007623 circadian rhythm 9/502 210/18722 0.112960610675395 0.240698196676359 NAMPT/EGR1/ATG7/NRIP1/SETX/AHR/ZFHX3/JUN/ATF5 9 GO:0021762 substantia nigra development 3/502 44/18722 0.113529874038337 0.241355329642163 ACTB/GNB4/CALM2 3 GO:0030521 androgen receptor signaling pathway 3/502 44/18722 0.113529874038337 0.241355329642163 DAB2/DDX17/DDX5 3 GO:0032007 negative regulation of TOR signaling 3/502 44/18722 0.113529874038337 0.241355329642163 ATM/HIF1A/SESN1 3 GO:0032881 regulation of polysaccharide metabolic process 3/502 44/18722 0.113529874038337 0.241355329642163 IGF1/CLTC/TGFB1 3 GO:0060711 labyrinthine layer development 3/502 44/18722 0.113529874038337 0.241355329642163 ZFP36L1/RBPJ/JUNB 3 GO:0010611 regulation of cardiac muscle hypertrophy 4/502 69/18722 0.113917219252635 0.241845367720371 IGF1/TNFRSF1B/MEF2A/TNFRSF1A 4 GO:0034605 cellular response to heat 4/502 69/18722 0.113917219252635 0.241845367720371 TFEC/HSPA1A/LYN/ATM 4 GO:0050810 regulation of steroid biosynthetic process 4/502 69/18722 0.113917219252635 0.241845367720371 APOE/ASAH1/EGR1/TSPO 4 GO:0060047 heart contraction 10/502 241/18722 0.115056205942591 0.244151380133222 ATP1B1/TMIGD3/CELF2/MEF2A/SLC8A1/JAK2/GPX1/GAA/CALM2/GSN 10 GO:0034620 cellular response to unfolded protein 5/502 96/18722 0.115696037961424 0.245396548193281 HSPA1A/XBP1/TMBIM6/PIK3R1/HERPUD1 5 GO:0060070 canonical Wnt signaling pathway 12/502 303/18722 0.116375662549259 0.245406679461933 ZEB2/IGFBP4/APOE/DAB2/RBPJ/NR4A2/EGR1/FOXO3/KLF4/TGFB1/ATP6AP2/STK4 12 GO:0002053 positive regulation of mesenchymal cell proliferation 2/502 22/18722 0.116632241389853 0.245406679461933 TGFBR2/STAT1 2 GO:0007398 ectoderm development 2/502 22/18722 0.116632241389853 0.245406679461933 ITGAM/ETS2 2 GO:0007413 axonal fasciculation 2/502 22/18722 0.116632241389853 0.245406679461933 NRP1/RTN4 2 GO:0010310 regulation of hydrogen peroxide metabolic process 2/502 22/18722 0.116632241389853 0.245406679461933 SOD2/STAT3 2 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/502 22/18722 0.116632241389853 0.245406679461933 SLC8A1/CALM2 2 GO:0032693 negative regulation of interleukin-10 production 2/502 22/18722 0.116632241389853 0.245406679461933 TYROBP/FCGR2B 2 GO:0034755 iron ion transmembrane transport 2/502 22/18722 0.116632241389853 0.245406679461933 MCOLN1/SLC11A2 2 GO:0035561 regulation of chromatin binding 2/502 22/18722 0.116632241389853 0.245406679461933 PARP9/DTX3L 2 GO:0035584 calcium-mediated signaling using intracellular calcium source 2/502 22/18722 0.116632241389853 0.245406679461933 PTPRC/PRNP 2 GO:0045624 positive regulation of T-helper cell differentiation 2/502 22/18722 0.116632241389853 0.245406679461933 CD86/NFKBIZ 2 GO:0061042 vascular wound healing 2/502 22/18722 0.116632241389853 0.245406679461933 ALOX5/XBP1 2 GO:0090280 positive regulation of calcium ion import 2/502 22/18722 0.116632241389853 0.245406679461933 CCL2/CCL3 2 GO:0099563 modification of synaptic structure 2/502 22/18722 0.116632241389853 0.245406679461933 ITSN1/CYFIP1 2 GO:0106030 neuron projection fasciculation 2/502 22/18722 0.116632241389853 0.245406679461933 NRP1/RTN4 2 GO:1900120 regulation of receptor binding 2/502 22/18722 0.116632241389853 0.245406679461933 B2M/NRP1 2 GO:1900543 negative regulation of purine nucleotide metabolic process 2/502 22/18722 0.116632241389853 0.245406679461933 NUPR1/STAT3 2 GO:0007368 determination of left/right symmetry 6/502 124/18722 0.116655704309726 0.245406679461933 MEF2C/TGFBR2/ENG/AP1B1/HIF1A/CITED2 6 GO:1903320 regulation of protein modification by small protein conjugation or removal 10/502 242/18722 0.117328783026051 0.246710431944779 LAPTM5/ARRB2/HSPA1A/ISG15/EGR1/DTX3L/TSPO/IVNS1ABP/HIF1A/HERPUD1 10 GO:0022602 ovulation cycle process 3/502 45/18722 0.119351283359017 0.250394121006264 ARRB2/FOXO3/NRIP1 3 GO:0035272 exocrine system development 3/502 45/18722 0.119351283359017 0.250394121006264 PLXND1/NRP1/TGFB1 3 GO:0042551 neuron maturation 3/502 45/18722 0.119351283359017 0.250394121006264 C1QA/RB1/NR4A2 3 GO:0060421 positive regulation of heart growth 3/502 45/18722 0.119351283359017 0.250394121006264 MEF2C/IGF1/RBPJ 3 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 3/502 45/18722 0.119351283359017 0.250394121006264 HSPA1A/CHCHD10/BNIP3L 3 GO:0043255 regulation of carbohydrate biosynthetic process 5/502 97/18722 0.119469712629074 0.250528962204033 IGF1/PLEK/CLTC/TGFB1/RANBP2 5 GO:0000082 G1/S transition of mitotic cell cycle 9/502 214/18722 0.122797794871368 0.257274727841915 CCL2/AIF1/GPNMB/RB1/ATM/KLF4/BCAT1/PTPN6/KMT2E 9 GO:0044242 cellular lipid catabolic process 9/502 214/18722 0.122797794871368 0.257274727841915 ENPP2/ASAH1/PLA2G15/PPT1/ACER3/FUCA1/MGST2/LRP1/HEXA 9 GO:0008344 adult locomotory behavior 4/502 71/18722 0.122995631597425 0.257572563046486 NR4A2/ARRB2/PPT1/EPS8 4 GO:0031929 TOR signaling 6/502 126/18722 0.123283813201908 0.257977783989125 GAS6/NCKAP1L/CCDC88A/ATM/HIF1A/SESN1 6 GO:0043473 pigmentation 5/502 98/18722 0.123300665888447 0.257977783989125 MEF2C/ZEB2/MYO5A/CD63/ATP6AP2 5 GO:0051147 regulation of muscle cell differentiation 7/502 155/18722 0.123865207162541 0.259041794002673 MEF2C/IGF1/ARRB2/SOD2/XBP1/ENG/TGFB1 7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 3/502 46/18722 0.125280689180141 0.260838844542215 CD209/ICAM1/CD164 3 GO:0042398 cellular modified amino acid biosynthetic process 3/502 46/18722 0.125280689180141 0.260838844542215 GATM/PLSCR1/MGST2 3 GO:0055010 ventricular cardiac muscle tissue morphogenesis 3/502 46/18722 0.125280689180141 0.260838844542215 RBPJ/ENG/TGFB1 3 GO:0060976 coronary vasculature development 3/502 46/18722 0.125280689180141 0.260838844542215 SPRED1/PLXND1/NRP1 3 GO:0072599 establishment of protein localization to endoplasmic reticulum 3/502 46/18722 0.125280689180141 0.260838844542215 MAN1A1/TRAM1/HERPUD1 3 GO:0002040 sprouting angiogenesis 8/502 185/18722 0.125360441035325 0.260838844542215 SPRED1/KLF2/ALOX5/NRP1/RNF213/GLUL/KLF4/NR4A1 8 GO:0006541 glutamine metabolic process 2/502 23/18722 0.125570278165913 0.260838844542215 GLUL/GLS 2 GO:0019430 removal of superoxide radicals 2/502 23/18722 0.125570278165913 0.260838844542215 CD36/SOD2 2 GO:0030325 adrenal gland development 2/502 23/18722 0.125570278165913 0.260838844542215 TSPO/CITED2 2 GO:0042026 protein refolding 2/502 23/18722 0.125570278165913 0.260838844542215 B2M/HSPA1A 2 GO:0045980 negative regulation of nucleotide metabolic process 2/502 23/18722 0.125570278165913 0.260838844542215 NUPR1/STAT3 2 GO:0051457 maintenance of protein location in nucleus 2/502 23/18722 0.125570278165913 0.260838844542215 SP100/CHCHD10 2 GO:0060487 lung epithelial cell differentiation 2/502 23/18722 0.125570278165913 0.260838844542215 RBPJ/KLF2 2 GO:0071636 positive regulation of transforming growth factor beta production 2/502 23/18722 0.125570278165913 0.260838844542215 LGALS9/ATP6AP2 2 GO:2001169 regulation of ATP biosynthetic process 2/502 23/18722 0.125570278165913 0.260838844542215 TMSB4X/STAT3 2 GO:0030048 actin filament-based movement 6/502 127/18722 0.12666592338255 0.262996661385851 MYO5A/WIPF1/MYO1F/WAS/MYO9B/GSN 6 GO:0003300 cardiac muscle hypertrophy 5/502 99/18722 0.127188055297788 0.263725658362873 IGF1/TNFRSF1B/MEF2A/TNFRSF1A/AKAP13 5 GO:0051153 regulation of striated muscle cell differentiation 5/502 99/18722 0.127188055297788 0.263725658362873 MEF2C/IGF1/ARRB2/XBP1/TGFB1 5 GO:0060996 dendritic spine development 5/502 99/18722 0.127188055297788 0.263725658362873 MEF2C/APOE/ITSN1/ACTR2/ADAM10 5 GO:0014743 regulation of muscle hypertrophy 4/502 72/18722 0.127647158087954 0.264322181430115 IGF1/TNFRSF1B/MEF2A/TNFRSF1A 4 GO:0051057 positive regulation of small GTPase mediated signal transduction 4/502 72/18722 0.127647158087954 0.264322181430115 LPAR6/IGF1/GPR65/AKAP13 4 GO:1905818 regulation of chromosome separation 4/502 72/18722 0.127647158087954 0.264322181430115 RB1/ATM/DUSP1/PLSCR1 4 GO:0008217 regulation of blood pressure 8/502 186/18722 0.128133614185717 0.264973669746592 GAS6/CTSZ/CYBA/NAMPT/SOD2/SGK1/ATP6AP2/PRCP 8 GO:0071478 cellular response to radiation 8/502 186/18722 0.128133614185717 0.264973669746592 IFI16/CYBA/NAMPT/ATM/EGR1/TIMP1/RHOB/PIK3R1 8 GO:0120032 regulation of plasma membrane bounded cell projection assembly 8/502 186/18722 0.128133614185717 0.264973669746592 ICAM1/CCDC88A/NRP1/ACTR2/CYFIP1/WAS/EPS8/PIK3R1 8 GO:0007389 pattern specification process 16/502 436/18722 0.128445057715226 0.265499033507879 C1QA/MEF2C/MAFB/ITGAM/RBPJ/NRP1/BTG2/TGFBR2/ENG/AP1B1/PRKACB/ATP6AP2/HIF1A/ETS2/ABI1/CITED2 16 GO:0010761 fibroblast migration 3/502 47/18722 0.131313985732457 0.270462376668899 ARHGAP4/SLC8A1/TGFB1 3 GO:0045332 phospholipid translocation 3/502 47/18722 0.131313985732457 0.270462376668899 ATP8B4/ABCA1/PLSCR1 3 GO:0045581 negative regulation of T cell differentiation 3/502 47/18722 0.131313985732457 0.270462376668899 RUNX1/CD74/FGL2 3 GO:0050885 neuromuscular process controlling balance 3/502 47/18722 0.131313985732457 0.270462376668899 TPP1/GAA/SLC1A3 3 GO:0090279 regulation of calcium ion import 3/502 47/18722 0.131313985732457 0.270462376668899 CCL2/CCL3/PRNP 3 GO:0097300 programmed necrotic cell death 3/502 47/18722 0.131313985732457 0.270462376668899 ASAH1/PYGL/NUPR1 3 GO:0101023 vascular endothelial cell proliferation 3/502 47/18722 0.131313985732457 0.270462376668899 MEF2C/CCL2/STAT3 3 GO:1905562 regulation of vascular endothelial cell proliferation 3/502 47/18722 0.131313985732457 0.270462376668899 MEF2C/CCL2/STAT3 3 GO:0032456 endocytic recycling 4/502 73/18722 0.132371317576347 0.272034524703768 EHD4/EPS15/ACAP2/ARL4C 4 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 4/502 73/18722 0.132371317576347 0.272034524703768 HLA-DRB1/UCP2/HIF1A/LRP1 4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 4/502 73/18722 0.132371317576347 0.272034524703768 CCDC88A/SNX6/NCF1/DUSP3 4 GO:0045739 positive regulation of DNA repair 4/502 73/18722 0.132371317576347 0.272034524703768 PARP9/ACTR2/DTX3L/WAS 4 GO:0072089 stem cell proliferation 4/502 73/18722 0.132371317576347 0.272034524703768 RUNX1/PTPRC/ZFP36L1/N4BP2L2 4 GO:0007163 establishment or maintenance of cell polarity 9/502 218/18722 0.133081638403428 0.273251513206505 NCKAP1L/CCL4/FRMD4B/ACTB/CYTH1/ACTR2/MSN/RHOB/GSN 9 GO:0042445 hormone metabolic process 9/502 218/18722 0.133081638403428 0.273251513206505 SPP1/CTSB/CTSZ/ALDH1A1/EGR1/TSPO/DHRS3/ATP6AP2/HIF1A 9 GO:0007498 mesoderm development 6/502 129/18722 0.133563717835332 0.274069085846982 ZFP36L1/JAK2/KLF4/ETS2/CITED2/PRKAR1A 6 GO:0006575 cellular modified amino acid metabolic process 8/502 188/18722 0.13377467584146 0.274069085846982 HPGDS/GATM/CTSB/PLA2G15/PLSCR1/GPX1/MGST2/SERINC1 8 GO:0060491 regulation of cell projection assembly 8/502 188/18722 0.13377467584146 0.274069085846982 ICAM1/CCDC88A/NRP1/ACTR2/CYFIP1/WAS/EPS8/PIK3R1 8 GO:0046883 regulation of hormone secretion 10/502 249/18722 0.13392922521472 0.274069085846982 SPP1/HLA-DRB1/ITSN1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 10 GO:0034655 nucleobase-containing compound catabolic process 15/502 407/18722 0.134285916963465 0.274069085846982 RNASE6/TNFRSF1B/ZFP36L1/OAS2/RNASET2/SAMHD1/ZFP36/TYMP/HSPA1A/ATM/BTG2/VIM/ZFP36L2/DDX5/MGAT1 15 GO:0001779 natural killer cell differentiation 2/502 24/18722 0.134664728086941 0.274069085846982 GAS6/PTPRC 2 GO:0001783 B cell apoptotic process 2/502 24/18722 0.134664728086941 0.274069085846982 CD74/LYN 2 GO:0016486 peptide hormone processing 2/502 24/18722 0.134664728086941 0.274069085846982 CTSZ/ATP6AP2 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/502 24/18722 0.134664728086941 0.274069085846982 TMSB4X/STAT3 2 GO:0031639 plasminogen activation 2/502 24/18722 0.134664728086941 0.274069085846982 RUNX1/CTSZ 2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 2/502 24/18722 0.134664728086941 0.274069085846982 IGF1/IGFBP4 2 GO:0048641 regulation of skeletal muscle tissue development 2/502 24/18722 0.134664728086941 0.274069085846982 MEF2C/TGFB1 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/502 24/18722 0.134664728086941 0.274069085846982 APOE/HIF1A 2 GO:0060479 lung cell differentiation 2/502 24/18722 0.134664728086941 0.274069085846982 RBPJ/KLF2 2 GO:0071676 negative regulation of mononuclear cell migration 2/502 24/18722 0.134664728086941 0.274069085846982 CCL2/DUSP1 2 GO:0072010 glomerular epithelium development 2/502 24/18722 0.134664728086941 0.274069085846982 PECAM1/IQGAP1 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/502 24/18722 0.134664728086941 0.274069085846982 TMSB4X/STAT3 2 GO:2000209 regulation of anoikis 2/502 24/18722 0.134664728086941 0.274069085846982 PDK4/MCL1 2 GO:2000353 positive regulation of endothelial cell apoptotic process 2/502 24/18722 0.134664728086941 0.274069085846982 CCL2/FOXO3 2 GO:2001026 regulation of endothelial cell chemotaxis 2/502 24/18722 0.134664728086941 0.274069085846982 LGMN/TMSB4X 2 GO:0006576 cellular biogenic amine metabolic process 5/502 101/18722 0.135128640107995 0.274771467753664 ITGB2/ITGAM/NR4A2/HNMT/SAT1 5 GO:0048024 regulation of mRNA splicing, via spliceosome 5/502 101/18722 0.135128640107995 0.274771467753664 CELF2/QKI/MBNL1/DDX17/DDX5 5 GO:0070972 protein localization to endoplasmic reticulum 4/502 74/18722 0.13716638125482 0.278792477893144 MAN1A1/RTN4/TRAM1/HERPUD1 4 GO:0002673 regulation of acute inflammatory response 3/502 48/18722 0.137447052889786 0.27899520257488 FCGR2B/ALOX5AP/HLA-E 3 GO:0002686 negative regulation of leukocyte migration 3/502 48/18722 0.137447052889786 0.27899520257488 CCL2/PTGER4/DUSP1 3 GO:0097720 calcineurin-mediated signaling 3/502 48/18722 0.137447052889786 0.27899520257488 IGF1/PRNP/CLEC7A 3 GO:0014897 striated muscle hypertrophy 5/502 102/18722 0.139180021431086 0.282265137720387 IGF1/TNFRSF1B/MEF2A/TNFRSF1A/AKAP13 5 GO:1902749 regulation of cell cycle G2/M phase transition 5/502 102/18722 0.139180021431086 0.282265137720387 ATM/NABP1/TAOK3/ATF5/TAOK1 5 GO:0019827 stem cell population maintenance 6/502 131/18722 0.140636019136542 0.285092999353919 RBPJ/SPI1/ZFP36L2/FOXO3/KLF4/STAT3 6 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 9/502 221/18722 0.141081361470852 0.285870511679441 APOE/DAB2/LAPTM5/CTSC/HSPA1A/SDCBP/GPX1/NUPR1/HERPUD1 9 GO:0018105 peptidyl-serine phosphorylation 12/502 315/18722 0.142019858787267 0.287542015281231 GAS6/MKNK1/SYK/ARRB2/ATM/TGFBR2/CD44/SGK1/TGFB1/CREBL2/CAB39/STK4 12 GO:0006024 glycosaminoglycan biosynthetic process 4/502 75/18722 0.142030589044015 0.287542015281231 CLTC/TGFB1/DSE/HEXA 4 GO:0030148 sphingolipid biosynthetic process 5/502 103/18722 0.143284213072328 0.288146326123954 ASAH1/SGMS1/ST8SIA4/SPTLC2/ACER3 5 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3/502 49/18722 0.143675764034384 0.288146326123954 CD28/PTPRC/TGFB1 3 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3/502 49/18722 0.143675764034384 0.288146326123954 CD28/PTPRC/TGFB1 3 GO:0006953 acute-phase response 3/502 49/18722 0.143675764034384 0.288146326123954 CD163/PLSCR1/STAT3 3 GO:0008038 neuron recognition 3/502 49/18722 0.143675764034384 0.288146326123954 NRP1/EMB/RTN4 3 GO:0034332 adherens junction organization 3/502 49/18722 0.143675764034384 0.288146326123954 MTSS1/ACTB/ADAM10 3 GO:0043330 response to exogenous dsRNA 3/502 49/18722 0.143675764034384 0.288146326123954 IFIT1/IFIH1/COLEC12 3 GO:0043457 regulation of cellular respiration 3/502 49/18722 0.143675764034384 0.288146326123954 NUPR1/HIF1A/IFNAR1 3 GO:0045190 isotype switching 3/502 49/18722 0.143675764034384 0.288146326123954 CD28/PTPRC/TGFB1 3 GO:0051445 regulation of meiotic cell cycle 3/502 49/18722 0.143675764034384 0.288146326123954 DUSP1/PRKACB/PRKAR1A 3 GO:0072091 regulation of stem cell proliferation 3/502 49/18722 0.143675764034384 0.288146326123954 PTPRC/ZFP36L1/N4BP2L2 3 GO:1904894 positive regulation of receptor signaling pathway via STAT 3/502 49/18722 0.143675764034384 0.288146326123954 IL10RA/JAK2/TGFB1 3 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 2/502 25/18722 0.143900822140034 0.288146326123954 GAS6/CYBA 2 GO:0003094 glomerular filtration 2/502 25/18722 0.143900822140034 0.288146326123954 GAS6/CYBA 2 GO:0030318 melanocyte differentiation 2/502 25/18722 0.143900822140034 0.288146326123954 MEF2C/ZEB2 2 GO:0032469 endoplasmic reticulum calcium ion homeostasis 2/502 25/18722 0.143900822140034 0.288146326123954 TMBIM6/HERPUD1 2 GO:0071450 cellular response to oxygen radical 2/502 25/18722 0.143900822140034 0.288146326123954 CD36/SOD2 2 GO:0071451 cellular response to superoxide 2/502 25/18722 0.143900822140034 0.288146326123954 CD36/SOD2 2 GO:0072012 glomerulus vasculature development 2/502 25/18722 0.143900822140034 0.288146326123954 PECAM1/EGR1 2 GO:0098703 calcium ion import across plasma membrane 2/502 25/18722 0.143900822140034 0.288146326123954 PRNP/SLC8A1 2 GO:0140448 signaling receptor ligand precursor processing 2/502 25/18722 0.143900822140034 0.288146326123954 CTSZ/ATP6AP2 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/502 25/18722 0.143900822140034 0.288146326123954 MEF2C/GNA13 2 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 2/502 25/18722 0.143900822140034 0.288146326123954 IQGAP1/LRP1 2 GO:1905563 negative regulation of vascular endothelial cell proliferation 2/502 25/18722 0.143900822140034 0.288146326123954 MEF2C/CCL2 2 GO:2000316 regulation of T-helper 17 type immune response 2/502 25/18722 0.143900822140034 0.288146326123954 CLEC7A/NFKBIZ 2 GO:0060828 regulation of canonical Wnt signaling pathway 10/502 253/18722 0.143948586180816 0.288146326123954 ZEB2/IGFBP4/APOE/DAB2/RBPJ/EGR1/FOXO3/TGFB1/ATP6AP2/STK4 10 GO:0007569 cell aging 6/502 132/18722 0.144236199015246 0.288347734072831 ICAM1/B2M/SPI1/NAMPT/ATM/CITED2 6 GO:0035264 multicellular organism growth 6/502 132/18722 0.144236199015246 0.288347734072831 IGF1/LGMN/ZFP36L1/KLF2/STAT3/ATF5 6 GO:0072175 epithelial tube formation 6/502 132/18722 0.144236199015246 0.288347734072831 TGFB1/PRKACB/HIF1A/CITED2/STK4/PLXNB2 6 GO:0006305 DNA alkylation 4/502 76/18722 0.146962152385644 0.293163827915476 SPI1/FOS/ATF7IP/KMT2E 4 GO:0006306 DNA methylation 4/502 76/18722 0.146962152385644 0.293163827915476 SPI1/FOS/ATF7IP/KMT2E 4 GO:0043536 positive regulation of blood vessel endothelial cell migration 4/502 76/18722 0.146962152385644 0.293163827915476 TMSB4X/NRP1/TGFB1/HIF1A 4 GO:0140029 exocytic process 4/502 76/18722 0.146962152385644 0.293163827915476 PLEK/SYK/LYN/RAB8B 4 GO:0140115 export across plasma membrane 4/502 76/18722 0.146962152385644 0.293163827915476 ATP1B1/ABCA1/SLC8A1/CALM2 4 GO:0032006 regulation of TOR signaling 5/502 104/18722 0.147440250363998 0.293990775079248 GAS6/NCKAP1L/ATM/HIF1A/SESN1 5 GO:0009855 determination of bilateral symmetry 6/502 133/18722 0.147878280069635 0.294610216882916 MEF2C/TGFBR2/ENG/AP1B1/HIF1A/CITED2 6 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 6/502 133/18722 0.147878280069635 0.294610216882916 DAB2/LAPTM5/CTSC/HSPA1A/NUPR1/HERPUD1 6 GO:0006633 fatty acid biosynthetic process 7/502 163/18722 0.149115743208737 0.296819891602244 HPGDS/CD74/TBXAS1/ALOX5/PDK4/XBP1/QKI 7 GO:0061025 membrane fusion 7/502 163/18722 0.149115743208737 0.296819891602244 FOLR2/GAS6/STX7/SAMD9/STX12/GCA/RAB8B 7 GO:0070231 T cell apoptotic process 3/502 50/18722 0.14999599340271 0.298315333396792 LGALS9/TSC22D3/HIF1A 3 GO:1904036 negative regulation of epithelial cell apoptotic process 3/502 50/18722 0.14999599340271 0.298315333396792 GAS6/ICAM1/NUPR1 3 GO:0009799 specification of symmetry 6/502 134/18722 0.151561654202509 0.30117019430447 MEF2C/TGFBR2/ENG/AP1B1/HIF1A/CITED2 6 GO:0061041 regulation of wound healing 6/502 134/18722 0.151561654202509 0.30117019430447 APOE/CD36/SERPING1/ALOX5/CLEC7A/XBP1 6 GO:0034976 response to endoplasmic reticulum stress 10/502 256/18722 0.151710712402197 0.301184028587305 FCGR2B/MAN1A1/ALOX5/HSPA1A/XBP1/NUPR1/TMBIM6/JUN/PIK3R1/HERPUD1 10 GO:1903522 regulation of blood circulation 10/502 256/18722 0.151710712402197 0.301184028587305 ATP1B1/TMIGD3/ICAM1/CELF2/TBXAS1/MEF2A/SLC8A1/JAK2/GAA/CALM2 10 GO:0000380 alternative mRNA splicing, via spliceosome 4/502 77/18722 0.151959256965579 0.301184028587305 CELF2/MBNL1/DDX17/DDX5 4 GO:0010827 regulation of glucose transmembrane transport 4/502 77/18722 0.151959256965579 0.301184028587305 IGF1/MEF2A/CREBL2/PIK3R1 4 GO:0021675 nerve development 4/502 77/18722 0.151959256965579 0.301184028587305 MAFB/NRP1/SLC1A3/CITED2 4 GO:0032418 lysosome localization 4/502 77/18722 0.151959256965579 0.301184028587305 CD84/LGALS9/SYK/LYN 4 GO:0001573 ganglioside metabolic process 2/502 26/18722 0.153264468017054 0.301831174562322 ST8SIA4/HEXA 2 GO:0002026 regulation of the force of heart contraction 2/502 26/18722 0.153264468017054 0.301831174562322 SLC8A1/GAA 2 GO:0006706 steroid catabolic process 2/502 26/18722 0.153264468017054 0.301831174562322 SPP1/APOE 2 GO:0009435 NAD biosynthetic process 2/502 26/18722 0.153264468017054 0.301831174562322 PARP9/NAMPT 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/502 26/18722 0.153264468017054 0.301831174562322 NCKAP1L/GNAI2 2 GO:0033598 mammary gland epithelial cell proliferation 2/502 26/18722 0.153264468017054 0.301831174562322 GPX1/RTN4 2 GO:0034114 regulation of heterotypic cell-cell adhesion 2/502 26/18722 0.153264468017054 0.301831174562322 CD44/KLF4 2 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 2/502 26/18722 0.153264468017054 0.301831174562322 HLA-E/LAMP1 2 GO:0048668 collateral sprouting 2/502 26/18722 0.153264468017054 0.301831174562322 SPP1/LRP1 2 GO:0071425 hematopoietic stem cell proliferation 2/502 26/18722 0.153264468017054 0.301831174562322 RUNX1/N4BP2L2 2 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 2/502 26/18722 0.153264468017054 0.301831174562322 GNAI2/AKAP13 2 GO:0097205 renal filtration 2/502 26/18722 0.153264468017054 0.301831174562322 GAS6/CYBA 2 GO:1902656 calcium ion import into cytosol 2/502 26/18722 0.153264468017054 0.301831174562322 PRNP/SLC8A1 2 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 2/502 26/18722 0.153264468017054 0.301831174562322 SOD2/ENG 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/502 26/18722 0.153264468017054 0.301831174562322 DAB2/RNF213 2 GO:0009895 negative regulation of catabolic process 12/502 320/18722 0.153533851604612 0.30210446513098 TIMP2/IL10RA/CST3/ZFP36/NAMPT/ATG7/SDCBP/TSPO/MCL1/NUPR1/TIMP1/STAT3 12 GO:0016042 lipid catabolic process 12/502 320/18722 0.153533851604612 0.30210446513098 SPP1/ENPP2/APOE/ASAH1/LIPA/PLA2G15/PPT1/ACER3/FUCA1/MGST2/LRP1/HEXA 12 GO:0050796 regulation of insulin secretion 7/502 165/18722 0.15578160155049 0.306396976518948 HLA-DRB1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1 7 GO:0007409 axonogenesis 15/502 418/18722 0.156130209968378 0.306952125505191 SPP1/APOE/PLXND1/ARHGAP4/NR4A2/NRP1/ACTB/EMB/CYFIP1/RTN4/LRP1/MACF1/GOLGA4/SKIL/PLXNB2 15 GO:0006636 unsaturated fatty acid biosynthetic process 3/502 51/18722 0.156403622936604 0.30722851792133 HPGDS/CD74/TBXAS1 3 GO:0045661 regulation of myoblast differentiation 3/502 51/18722 0.156403622936604 0.30722851792133 MEF2C/ZFP36L1/TGFB1 3 GO:0001763 morphogenesis of a branching structure 8/502 196/18722 0.157564125111646 0.309376758389845 PLXND1/CTSZ/NRP1/TGFBR2/ENG/RTN4/FEM1B/STK4 8 GO:0043624 cellular protein complex disassembly 6/502 136/18722 0.159049775742767 0.312028949357947 PLEK/CAPG/CAPZA2/EPS8/GSN/TAOK1 6 GO:0098876 vesicle-mediated transport to the plasma membrane 6/502 136/18722 0.159049775742767 0.312028949357947 EHD4/EPS15/ACAP2/ARL4C/MACF1/GOLGA4 6 GO:0051236 establishment of RNA localization 7/502 166/18722 0.159165271721458 0.31212316531728 ZFP36L1/MX2/ZFP36/ATM/TGFBR2/QKI/RANBP2 7 GO:0000018 regulation of DNA recombination 5/502 107/18722 0.160209481595178 0.313904727598177 CD28/PTPRC/ACTR2/WAS/TGFB1 5 GO:0005976 polysaccharide metabolic process 5/502 107/18722 0.160209481595178 0.313904727598177 IGF1/CLTC/PYGL/TGFB1/GAA 5 GO:0006023 aminoglycan biosynthetic process 4/502 79/18722 0.162142719646697 0.316617723579334 CLTC/TGFB1/DSE/HEXA 4 GO:0090150 establishment of protein localization to membrane 10/502 260/18722 0.162381792344229 0.316617723579334 ATP1B1/ITGB2/ITGAM/PRNP/SDCBP/NCF1/MACF1/TRAM1/GOLGA4/RAB8B 10 GO:0034767 positive regulation of ion transmembrane transport 7/502 167/18722 0.162582181856658 0.316617723579334 CCL2/ATP1B1/TMSB4X/CTSS/VMP1/IFNGR2/CALM2 7 GO:0001835 blastocyst hatching 2/502 27/18722 0.162742224563556 0.316617723579334 LPAR6/CMTM3 2 GO:0002719 negative regulation of cytokine production involved in immune response 2/502 27/18722 0.162742224563556 0.316617723579334 BST2/TGFB1 2 GO:0006783 heme biosynthetic process 2/502 27/18722 0.162742224563556 0.316617723579334 SLC11A2/TSPO 2 GO:0014850 response to muscle activity 2/502 27/18722 0.162742224563556 0.316617723579334 METRNL/HIF1A 2 GO:0034143 regulation of toll-like receptor 4 signaling pathway 2/502 27/18722 0.162742224563556 0.316617723579334 NINJ1/LYN 2 GO:0035188 hatching 2/502 27/18722 0.162742224563556 0.316617723579334 LPAR6/CMTM3 2 GO:0042104 positive regulation of activated T cell proliferation 2/502 27/18722 0.162742224563556 0.316617723579334 IGF1/PYCARD 2 GO:0042402 cellular biogenic amine catabolic process 2/502 27/18722 0.162742224563556 0.316617723579334 HNMT/SAT1 2 GO:0071684 organism emergence from protective structure 2/502 27/18722 0.162742224563556 0.316617723579334 LPAR6/CMTM3 2 GO:0006986 response to unfolded protein 6/502 137/18722 0.162853235056041 0.316617723579334 HSPA1A/XBP1/TMBIM6/TRAM1/PIK3R1/HERPUD1 6 GO:0050684 regulation of mRNA processing 6/502 137/18722 0.162853235056041 0.316617723579334 ZFP36L1/CELF2/QKI/MBNL1/DDX17/DDX5 6 GO:0090090 negative regulation of canonical Wnt signaling pathway 6/502 137/18722 0.162853235056041 0.316617723579334 IGFBP4/APOE/DAB2/EGR1/FOXO3/STK4 6 GO:0034204 lipid translocation 3/502 52/18722 0.162894548663817 0.316617723579334 ATP8B4/ABCA1/PLSCR1 3 GO:0051496 positive regulation of stress fiber assembly 3/502 52/18722 0.162894548663817 0.316617723579334 CCDC88A/NRP1/GPR65 3 GO:0072132 mesenchyme morphogenesis 3/502 52/18722 0.162894548663817 0.316617723579334 RBPJ/TGFBR2/ENG 3 GO:2000378 negative regulation of reactive oxygen species metabolic process 3/502 52/18722 0.162894548663817 0.316617723579334 ACP5/STAT3/HIF1A 3 GO:0034446 substrate adhesion-dependent cell spreading 5/502 108/18722 0.164562852248732 0.319726062369859 PEAK1/NRP1/PREX1/FERMT3/PIK3R1 5 GO:0009791 post-embryonic development 4/502 80/18722 0.167325343851429 0.324956776094337 SCN9A/NR4A2/KLF4/ATF5 4 GO:0072009 nephron epithelium development 5/502 109/18722 0.168962953156076 0.327999421443561 MEF2C/MTSS1/PECAM1/IQGAP1/STAT1 5 GO:0001541 ovarian follicle development 3/502 53/18722 0.169464686630862 0.328284606513554 ICAM1/ARRB2/FOXO3 3 GO:0016925 protein sumoylation 3/502 53/18722 0.169464686630862 0.328284606513554 EGR1/IFIH1/RANBP2 3 GO:0031279 regulation of cyclase activity 3/502 53/18722 0.169464686630862 0.328284606513554 TIMP2/GNAI2/CALM2 3 GO:0033059 cellular pigmentation 3/502 53/18722 0.169464686630862 0.328284606513554 ZEB2/MYO5A/CD63 3 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 3/502 53/18722 0.169464686630862 0.328284606513554 PLEK/ARRB2/GNAI2 3 GO:0051783 regulation of nuclear division 6/502 139/18722 0.170575631056439 0.330298396511967 IGF1/CD28/RB1/ATM/DUSP1/PRKAR1A 6 GO:0046879 hormone secretion 11/502 295/18722 0.170864824939634 0.330719949862237 SPP1/HLA-DRB1/ITSN1/ALOX5/LYN/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 11 GO:0002675 positive regulation of acute inflammatory response 2/502 28/18722 0.172321277107051 0.332287714838357 ALOX5AP/HLA-E 2 GO:0006516 glycoprotein catabolic process 2/502 28/18722 0.172321277107051 0.332287714838357 MAN1A1/CST3 2 GO:0009065 glutamine family amino acid catabolic process 2/502 28/18722 0.172321277107051 0.332287714838357 GLUL/GLS 2 GO:0010464 regulation of mesenchymal cell proliferation 2/502 28/18722 0.172321277107051 0.332287714838357 TGFBR2/STAT1 2 GO:0010884 positive regulation of lipid storage 2/502 28/18722 0.172321277107051 0.332287714838357 CD36/MSR1 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 2/502 28/18722 0.172321277107051 0.332287714838357 SNX6/DUSP3 2 GO:0051894 positive regulation of focal adhesion assembly 2/502 28/18722 0.172321277107051 0.332287714838357 NRP1/IQGAP1 2 GO:0060765 regulation of androgen receptor signaling pathway 2/502 28/18722 0.172321277107051 0.332287714838357 DAB2/DDX5 2 GO:1903671 negative regulation of sprouting angiogenesis 2/502 28/18722 0.172321277107051 0.332287714838357 KLF2/ALOX5 2 GO:0006096 glycolytic process 4/502 81/18722 0.172566046444271 0.332344101103746 IGF1/NUPR1/STAT3/HIF1A 4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 4/502 81/18722 0.172566046444271 0.332344101103746 SPRED1/HSPA1A/SNX6/SKIL 4 GO:1903533 regulation of protein targeting 4/502 81/18722 0.172566046444271 0.332344101103746 ITGB2/ITGAM/PRNP/BNIP3L 4 GO:0007088 regulation of mitotic nuclear division 5/502 110/18722 0.173408710655867 0.333550393136816 IGF1/CD28/RB1/ATM/DUSP1 5 GO:0018958 phenol-containing compound metabolic process 5/502 110/18722 0.173408710655867 0.333550393136816 ZEB2/CTSB/ITGB2/ITGAM/NR4A2 5 GO:1904659 glucose transmembrane transport 5/502 110/18722 0.173408710655867 0.333550393136816 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:0030177 positive regulation of Wnt signaling pathway 6/502 140/18722 0.17449320241313 0.335218253473065 ZEB2/DAB2/RBPJ/TGFB1/ATP6AP2/MACF1 6 GO:0031333 negative regulation of protein-containing complex assembly 6/502 140/18722 0.17449320241313 0.335218253473065 TMSB4X/PTGER4/CAPG/CAPZA2/EPS8/GSN 6 GO:0050768 negative regulation of neurogenesis 6/502 140/18722 0.17449320241313 0.335218253473065 SPP1/B2M/ARHGAP4/NRP1/TSPO/RTN4 6 GO:0006584 catecholamine metabolic process 3/502 54/18722 0.176109978410193 0.337763167547907 ITGB2/ITGAM/NR4A2 3 GO:0009712 catechol-containing compound metabolic process 3/502 54/18722 0.176109978410193 0.337763167547907 ITGB2/ITGAM/NR4A2 3 GO:0030520 intracellular estrogen receptor signaling pathway 3/502 54/18722 0.176109978410193 0.337763167547907 NCOA4/DDX17/DDX5 3 GO:0070839 metal ion export 3/502 54/18722 0.176109978410193 0.337763167547907 ATP1B1/SLC8A1/CALM2 3 GO:0046890 regulation of lipid biosynthetic process 7/502 171/18722 0.176573013704927 0.33851088329838 APOE/CD74/ASAH1/PDK4/EGR1/TSPO/CREBL2 7 GO:0006757 ATP generation from ADP 4/502 82/18722 0.177862922670026 0.34070139969836 IGF1/NUPR1/STAT3/HIF1A 4 GO:0009205 purine ribonucleoside triphosphate metabolic process 4/502 82/18722 0.177862922670026 0.34070139969836 TMSB4X/TGFB1/GIMAP7/STAT3 4 GO:0003002 regionalization 12/502 331/18722 0.180494880160953 0.345456895169454 C1QA/MEF2C/MAFB/ITGAM/RBPJ/NRP1/BTG2/PRKACB/ATP6AP2/ETS2/ABI1/CITED2 12 GO:0019216 regulation of lipid metabolic process 12/502 331/18722 0.180494880160953 0.345456895169454 APOE/CD74/NPC2/PSAP/ASAH1/LYN/CD81/PDK4/EGR1/TSPO/TGFB1/CREBL2 12 GO:0023061 signal release 16/502 463/18722 0.181675439796096 0.34588456346756 SPP1/MEF2C/HLA-DRB1/ITSN1/SYK/ABCA1/ALOX5/LYN/JAK2/GLUL/UCP2/NR4A1/PPT1/HIF1A/LRP1/RAB8B 16 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 2/502 29/18722 0.181989413635979 0.34588456346756 ZFP36/BTG2 2 GO:0009310 amine catabolic process 2/502 29/18722 0.181989413635979 0.34588456346756 HNMT/SAT1 2 GO:0010955 negative regulation of protein processing 2/502 29/18722 0.181989413635979 0.34588456346756 CTSZ/PRNP 2 GO:0019359 nicotinamide nucleotide biosynthetic process 2/502 29/18722 0.181989413635979 0.34588456346756 PARP9/NAMPT 2 GO:0019363 pyridine nucleotide biosynthetic process 2/502 29/18722 0.181989413635979 0.34588456346756 PARP9/NAMPT 2 GO:0032366 intracellular sterol transport 2/502 29/18722 0.181989413635979 0.34588456346756 NPC2/ABCA1 2 GO:0032367 intracellular cholesterol transport 2/502 29/18722 0.181989413635979 0.34588456346756 NPC2/ABCA1 2 GO:0042759 long-chain fatty acid biosynthetic process 2/502 29/18722 0.181989413635979 0.34588456346756 ALOX5/QKI 2 GO:0048265 response to pain 2/502 29/18722 0.181989413635979 0.34588456346756 SCN9A/TSPO 2 GO:0062098 regulation of programmed necrotic cell death 2/502 29/18722 0.181989413635979 0.34588456346756 ASAH1/NUPR1 2 GO:0072539 T-helper 17 cell differentiation 2/502 29/18722 0.181989413635979 0.34588456346756 STAT3/NFKBIZ 2 GO:0095500 acetylcholine receptor signaling pathway 2/502 29/18722 0.181989413635979 0.34588456346756 RGS10/GNAI2 2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/502 29/18722 0.181989413635979 0.34588456346756 CD74/CD44 2 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/502 29/18722 0.181989413635979 0.34588456346756 CD74/CD44 2 GO:1903318 negative regulation of protein maturation 2/502 29/18722 0.181989413635979 0.34588456346756 CTSZ/PRNP 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/502 29/18722 0.181989413635979 0.34588456346756 PARP9/DTX3L 2 GO:0009141 nucleoside triphosphate metabolic process 5/502 112/18722 0.182432830323058 0.346309519359403 TMSB4X/SAMHD1/TGFB1/GIMAP7/STAT3 5 GO:0007009 plasma membrane organization 6/502 142/18722 0.182437591586439 0.346309519359403 FOLR2/CR1/PTPRC/MTSS1/PLSCR1/GSN 6 GO:0072006 nephron development 6/502 142/18722 0.182437591586439 0.346309519359403 MEF2C/MTSS1/PECAM1/EGR1/IQGAP1/STAT1 6 GO:0003229 ventricular cardiac muscle tissue development 3/502 55/18722 0.182826396202762 0.34662086427622 RBPJ/ENG/TGFB1 3 GO:0008333 endosome to lysosome transport 3/502 55/18722 0.182826396202762 0.34662086427622 DENND3/DTX3L/RHOB 3 GO:0043331 response to dsRNA 3/502 55/18722 0.182826396202762 0.34662086427622 IFIT1/IFIH1/COLEC12 3 GO:0050886 endocrine process 4/502 83/18722 0.1832140568418 0.34707134600744 CTSZ/CYBA/ATP6AP2/RAB8B 4 GO:0051899 membrane depolarization 4/502 83/18722 0.1832140568418 0.34707134600744 SCN9A/SLC8A1/TSPO/JUN 4 GO:0030072 peptide hormone secretion 9/502 236/18722 0.184561433890378 0.349480635766225 HLA-DRB1/ITSN1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 9 GO:0044106 cellular amine metabolic process 5/502 113/18722 0.187008977890611 0.353970348495077 ITGB2/ITGAM/NR4A2/HNMT/SAT1 5 GO:0062012 regulation of small molecule metabolic process 12/502 334/18722 0.188219419231162 0.356115760066812 IGF1/IGFBP4/TMSB4X/APOE/CD74/PLEK/PDK4/EGR1/NUPR1/STAT3/HIF1A/RANBP2 12 GO:0061157 mRNA destabilization 4/502 84/18722 0.188617524554555 0.356723086095409 ZFP36L1/ZFP36/BTG2/ZFP36L2 4 GO:0010518 positive regulation of phospholipase activity 3/502 56/18722 0.189609947556172 0.358160725763516 CD86/C5AR1/GNA13 3 GO:0046622 positive regulation of organ growth 3/502 56/18722 0.189609947556172 0.358160725763516 MEF2C/IGF1/RBPJ 3 GO:0051784 negative regulation of nuclear division 3/502 56/18722 0.189609947556172 0.358160725763516 ATM/DUSP1/PRKAR1A 3 GO:0008016 regulation of heart contraction 8/502 206/18722 0.189876533852348 0.358517896163658 ATP1B1/TMIGD3/CELF2/MEF2A/SLC8A1/JAK2/GAA/CALM2 8 GO:0033135 regulation of peptidyl-serine phosphorylation 6/502 144/18722 0.190522850833379 0.358659975064427 GAS6/ARRB2/CD44/TGFB1/CREBL2/STK4 6 GO:0008645 hexose transmembrane transport 5/502 114/18722 0.191626354939607 0.358659975064427 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:1903008 organelle disassembly 5/502 114/18722 0.191626354939607 0.358659975064427 VPS13C/ATG7/TSPO/HIF1A/BNIP3L 5 GO:1904892 regulation of receptor signaling pathway via STAT 5/502 114/18722 0.191626354939607 0.358659975064427 PTPRC/IL10RA/PARP14/JAK2/TGFB1 5 GO:0007176 regulation of epidermal growth factor-activated receptor activity 2/502 30/18722 0.191735001801627 0.358659975064427 SNX6/NCF1 2 GO:0007202 activation of phospholipase C activity 2/502 30/18722 0.191735001801627 0.358659975064427 CD86/C5AR1 2 GO:0009264 deoxyribonucleotide catabolic process 2/502 30/18722 0.191735001801627 0.358659975064427 SAMHD1/TYMP 2 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/502 30/18722 0.191735001801627 0.358659975064427 SLC8A1/CALM2 2 GO:0017145 stem cell division 2/502 30/18722 0.191735001801627 0.358659975064427 ZFP36L2/EVI2B 2 GO:0034368 protein-lipid complex remodeling 2/502 30/18722 0.191735001801627 0.358659975064427 PLTP/APOE 2 GO:0034369 plasma lipoprotein particle remodeling 2/502 30/18722 0.191735001801627 0.358659975064427 PLTP/APOE 2 GO:0036296 response to increased oxygen levels 2/502 30/18722 0.191735001801627 0.358659975064427 ATG7/ATP6AP1 2 GO:0044788 modulation by host of viral process 2/502 30/18722 0.191735001801627 0.358659975064427 APOE/IFI27 2 GO:0048147 negative regulation of fibroblast proliferation 2/502 30/18722 0.191735001801627 0.358659975064427 FTH1/NUPR1 2 GO:0051491 positive regulation of filopodium assembly 2/502 30/18722 0.191735001801627 0.358659975064427 NRP1/PIK3R1 2 GO:0051968 positive regulation of synaptic transmission, glutamatergic 2/502 30/18722 0.191735001801627 0.358659975064427 CCL2/GLUL 2 GO:0060674 placenta blood vessel development 2/502 30/18722 0.191735001801627 0.358659975064427 RBPJ/JUNB 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/502 30/18722 0.191735001801627 0.358659975064427 RBPJ/TGFB1 2 GO:0061384 heart trabecula morphogenesis 2/502 30/18722 0.191735001801627 0.358659975064427 RBPJ/ENG 2 GO:0140058 neuron projection arborization 2/502 30/18722 0.191735001801627 0.358659975064427 NRP1/MACF1 2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 2/502 30/18722 0.191735001801627 0.358659975064427 XBP1/PIK3R1 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/502 30/18722 0.191735001801627 0.358659975064427 ITM2B/CST3 2 GO:2000648 positive regulation of stem cell proliferation 2/502 30/18722 0.191735001801627 0.358659975064427 PTPRC/N4BP2L2 2 GO:0055013 cardiac muscle cell development 4/502 85/18722 0.194071394824895 0.362737079781804 IGF1/MEF2A/SLC8A1/AKAP13 4 GO:2000779 regulation of double-strand break repair 4/502 85/18722 0.194071394824895 0.362737079781804 PARP9/ACTR2/DTX3L/WAS 4 GO:0051961 negative regulation of nervous system development 6/502 145/18722 0.194616472951117 0.363608967638073 SPP1/B2M/ARHGAP4/NRP1/TSPO/RTN4 6 GO:0006754 ATP biosynthetic process 3/502 57/18722 0.196456679717731 0.366159790642314 TMSB4X/TGFB1/STAT3 3 GO:0010883 regulation of lipid storage 3/502 57/18722 0.196456679717731 0.366159790642314 CD36/MSR1/ABCA1 3 GO:0016447 somatic recombination of immunoglobulin gene segments 3/502 57/18722 0.196456679717731 0.366159790642314 CD28/PTPRC/TGFB1 3 GO:0030219 megakaryocyte differentiation 3/502 57/18722 0.196456679717731 0.366159790642314 MEF2C/PTPN6/ABI1 3 GO:0051785 positive regulation of nuclear division 3/502 57/18722 0.196456679717731 0.366159790642314 IGF1/CD28/RB1 3 GO:0097120 receptor localization to synapse 3/502 57/18722 0.196456679717731 0.366159790642314 TYROBP/STX7/ADAM10 3 GO:0071466 cellular response to xenobiotic stimulus 7/502 177/18722 0.198475197716185 0.369772961995598 MEF2C/GAS6/RB1/ABCA1/PRNP/RNF149/AHR 7 GO:0048813 dendrite morphogenesis 6/502 146/18722 0.198743093933695 0.369994174702248 MEF2A/NRP1/SLC11A2/ACTR2/ABI1/ADAM10 6 GO:0018209 peptidyl-serine modification 12/502 338/18722 0.198753896267853 0.369994174702248 GAS6/MKNK1/SYK/ARRB2/ATM/TGFBR2/CD44/SGK1/TGFB1/CREBL2/CAB39/STK4 12 GO:0034249 negative regulation of cellular amide metabolic process 10/502 273/18722 0.199455913876833 0.37115167240315 IGF1/APOE/ZFP36L1/ZFP36/PRNP/CPEB4/BTG2/ZFP36L2/STAT3/RTN4 10 GO:0048864 stem cell development 4/502 86/18722 0.19957373215731 0.371221586232294 PTPRC/NRP1/HIF1A/CITED2 4 GO:0044843 cell cycle G1/S phase transition 9/502 241/18722 0.200247883588502 0.371308748717203 CCL2/AIF1/GPNMB/RB1/ATM/KLF4/BCAT1/PTPN6/KMT2E 9 GO:0006650 glycerophospholipid metabolic process 11/502 306/18722 0.200820812856577 0.371308748717203 CSF1R/ENPP2/PLEK/ATM/PLA2G15/PLSCR1/ETNK1/CEPT1/PIK3R1/EFR3A/SERINC1 11 GO:0009914 hormone transport 11/502 306/18722 0.200820812856577 0.371308748717203 SPP1/HLA-DRB1/ITSN1/ALOX5/LYN/JAK2/GLUL/UCP2/HIF1A/LRP1/RAB8B 11 GO:0015749 monosaccharide transmembrane transport 5/502 116/18722 0.200980249658427 0.371308748717203 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:0018107 peptidyl-threonine phosphorylation 5/502 116/18722 0.200980249658427 0.371308748717203 SPRED1/TGFBR2/TGFB1/CAB39/CALM2 5 GO:0030518 intracellular steroid hormone receptor signaling pathway 5/502 116/18722 0.200980249658427 0.371308748717203 DAB2/JAK2/NCOA4/DDX17/DDX5 5 GO:0035967 cellular response to topologically incorrect protein 5/502 116/18722 0.200980249658427 0.371308748717203 HSPA1A/XBP1/TMBIM6/PIK3R1/HERPUD1 5 GO:0002717 positive regulation of natural killer cell mediated immunity 2/502 31/18722 0.201546966716147 0.371308748717203 HLA-E/LAMP1 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/502 31/18722 0.201546966716147 0.371308748717203 SLC11A2/TSPO 2 GO:0033014 tetrapyrrole biosynthetic process 2/502 31/18722 0.201546966716147 0.371308748717203 SLC11A2/TSPO 2 GO:0046386 deoxyribose phosphate catabolic process 2/502 31/18722 0.201546966716147 0.371308748717203 SAMHD1/TYMP 2 GO:0048384 retinoic acid receptor signaling pathway 2/502 31/18722 0.201546966716147 0.371308748717203 KLF2/DHRS3 2 GO:0055022 negative regulation of cardiac muscle tissue growth 2/502 31/18722 0.201546966716147 0.371308748717203 TGFBR2/CITED2 2 GO:0060045 positive regulation of cardiac muscle cell proliferation 2/502 31/18722 0.201546966716147 0.371308748717203 MEF2C/RBPJ 2 GO:0060795 cell fate commitment involved in formation of primary germ layer 2/502 31/18722 0.201546966716147 0.371308748717203 KLF4/ETS2 2 GO:0061099 negative regulation of protein tyrosine kinase activity 2/502 31/18722 0.201546966716147 0.371308748717203 PTPRC/SNX6 2 GO:0061117 negative regulation of heart growth 2/502 31/18722 0.201546966716147 0.371308748717203 TGFBR2/CITED2 2 GO:0070633 transepithelial transport 2/502 31/18722 0.201546966716147 0.371308748717203 ACTB/SLC1A3 2 GO:0071168 protein localization to chromatin 2/502 31/18722 0.201546966716147 0.371308748717203 RB1/SPI1 2 GO:1901797 negative regulation of signal transduction by p53 class mediator 2/502 31/18722 0.201546966716147 0.371308748717203 CD74/CD44 2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/502 31/18722 0.201546966716147 0.371308748717203 ICAM1/GPX1 2 GO:1905144 response to acetylcholine 2/502 31/18722 0.201546966716147 0.371308748717203 RGS10/GNAI2 2 GO:1905145 cellular response to acetylcholine 2/502 31/18722 0.201546966716147 0.371308748717203 RGS10/GNAI2 2 GO:2000144 positive regulation of DNA-templated transcription, initiation 2/502 31/18722 0.201546966716147 0.371308748717203 SETX/JUN 2 GO:0016331 morphogenesis of embryonic epithelium 6/502 147/18722 0.202901956309036 0.373656230049999 TGFB1/PRKACB/HIF1A/CITED2/STK4/PLXNB2 6 GO:0002931 response to ischemia 3/502 58/18722 0.203362683640944 0.373760736798969 CSF1R/CPEB4/EGR1 3 GO:0086065 cell communication involved in cardiac conduction 3/502 58/18722 0.203362683640944 0.373760736798969 ATP1B1/SLC8A1/CALM2 3 GO:0097035 regulation of membrane lipid distribution 3/502 58/18722 0.203362683640944 0.373760736798969 ATP8B4/ABCA1/PLSCR1 3 GO:2000736 regulation of stem cell differentiation 3/502 58/18722 0.203362683640944 0.373760736798969 ZFP36L2/N4BP2L2/STAT3 3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 3/502 58/18722 0.203362683640944 0.373760736798969 MCL1/NUPR1/SKIL 3 GO:0031396 regulation of protein ubiquitination 8/502 210/18722 0.203531364215044 0.373922196528511 LAPTM5/ARRB2/HSPA1A/ISG15/DTX3L/TSPO/IVNS1ABP/HERPUD1 8 GO:0061014 positive regulation of mRNA catabolic process 4/502 87/18722 0.205122598537213 0.37669596698418 ZFP36L1/ZFP36/BTG2/ZFP36L2 4 GO:0035148 tube formation 6/502 148/18722 0.207092294949081 0.380011486090619 TGFB1/PRKACB/HIF1A/CITED2/STK4/PLXNB2 6 GO:0044839 cell cycle G2/M phase transition 6/502 148/18722 0.207092294949081 0.380011486090619 ATM/NABP1/TAOK3/ATF5/CALM2/TAOK1 6 GO:0010721 negative regulation of cell development 7/502 180/18722 0.209808273915737 0.384586993237303 SPP1/IGF1/B2M/ARHGAP4/NRP1/TSPO/RTN4 7 GO:0019369 arachidonic acid metabolic process 3/502 59/18722 0.210324097663144 0.384586993237303 TBXAS1/ALOX5/GPX1 3 GO:0071806 protein transmembrane transport 3/502 59/18722 0.210324097663144 0.384586993237303 ABCA1/MCL1/TRAM1 3 GO:0090303 positive regulation of wound healing 3/502 59/18722 0.210324097663144 0.384586993237303 CD36/CLEC7A/XBP1 3 GO:0009308 amine metabolic process 5/502 118/18722 0.210485333443197 0.384586993237303 ITGB2/ITGAM/NR4A2/HNMT/SAT1 5 GO:0034219 carbohydrate transmembrane transport 5/502 118/18722 0.210485333443197 0.384586993237303 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:0001843 neural tube closure 4/502 88/18722 0.210716055351267 0.384586993237303 TGFB1/PRKACB/CITED2/PLXNB2 4 GO:0016525 negative regulation of angiogenesis 6/502 149/18722 0.211313337600002 0.384586993237303 STAB1/SPRED1/KLF2/ALOX5/KLF4/STAT1 6 GO:0045834 positive regulation of lipid metabolic process 6/502 149/18722 0.211313337600002 0.384586993237303 APOE/CD74/LYN/CD81/TGFB1/CREBL2 6 GO:0003180 aortic valve morphogenesis 2/502 32/18722 0.211414769520636 0.384586993237303 RB1/TGFB1 2 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 2/502 32/18722 0.211414769520636 0.384586993237303 JAK2/NUPR1 2 GO:0019934 cGMP-mediated signaling 2/502 32/18722 0.211414769520636 0.384586993237303 APOE/CD36 2 GO:0034367 protein-containing complex remodeling 2/502 32/18722 0.211414769520636 0.384586993237303 PLTP/APOE 2 GO:0045761 regulation of adenylate cyclase activity 2/502 32/18722 0.211414769520636 0.384586993237303 TIMP2/GNAI2 2 GO:0045879 negative regulation of smoothened signaling pathway 2/502 32/18722 0.211414769520636 0.384586993237303 RB1/PRKACB 2 GO:0046475 glycerophospholipid catabolic process 2/502 32/18722 0.211414769520636 0.384586993237303 ENPP2/PLA2G15 2 GO:0051497 negative regulation of stress fiber assembly 2/502 32/18722 0.211414769520636 0.384586993237303 WAS/PIK3R1 2 GO:0060914 heart formation 2/502 32/18722 0.211414769520636 0.384586993237303 MEF2C/RBPJ 2 GO:0071875 adrenergic receptor signaling pathway 2/502 32/18722 0.211414769520636 0.384586993237303 GNAI2/AKAP13 2 GO:0072525 pyridine-containing compound biosynthetic process 2/502 32/18722 0.211414769520636 0.384586993237303 PARP9/NAMPT 2 GO:1901532 regulation of hematopoietic progenitor cell differentiation 2/502 32/18722 0.211414769520636 0.384586993237303 SPI1/N4BP2L2 2 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 2/502 32/18722 0.211414769520636 0.384586993237303 RUNX1/LGALS9 2 GO:0046034 ATP metabolic process 10/502 277/18722 0.211546290283031 0.384674975962776 IGF1/ATP1B1/TMSB4X/HSPA1A/TSPO/TGFB1/NUPR1/STAT3/HIF1A/CHCHD10 10 GO:0016055 Wnt signaling pathway 15/502 444/18722 0.214612917191989 0.390097978361549 ZEB2/IGFBP4/APOE/DAB2/RBPJ/NR4A2/RNF213/EGR1/FOXO3/KLF4/TGFB1/ATP6AP2/LRP1/MACF1/STK4 15 GO:0009199 ribonucleoside triphosphate metabolic process 4/502 89/18722 0.216352165235547 0.392950575728167 TMSB4X/TGFB1/GIMAP7/STAT3 4 GO:0060606 tube closure 4/502 89/18722 0.216352165235547 0.392950575728167 TGFB1/PRKACB/CITED2/PLXNB2 4 GO:0019731 antibacterial humoral response 3/502 60/18722 0.217337110871242 0.3942750881923 RNASE6/HLA-A/HLA-E 3 GO:0030071 regulation of mitotic metaphase/anaphase transition 3/502 60/18722 0.217337110871242 0.3942750881923 RB1/ATM/DUSP1 3 GO:0055008 cardiac muscle tissue morphogenesis 3/502 60/18722 0.217337110871242 0.3942750881923 RBPJ/ENG/TGFB1 3 GO:0061138 morphogenesis of a branching epithelium 7/502 182/18722 0.21749518535149 0.394380541190541 PLXND1/CTSZ/NRP1/TGFBR2/ENG/FEM1B/STK4 7 GO:0072330 monocarboxylic acid biosynthetic process 8/502 214/18722 0.217565746026429 0.394380541190541 HPGDS/GATM/CD74/TBXAS1/ALOX5/PDK4/XBP1/QKI 8 GO:0198738 cell-cell signaling by wnt 15/502 446/18722 0.219476950938967 0.397689140244286 ZEB2/IGFBP4/APOE/DAB2/RBPJ/NR4A2/RNF213/EGR1/FOXO3/KLF4/TGFB1/ATP6AP2/LRP1/MACF1/STK4 15 GO:0030900 forebrain development 13/502 379/18722 0.219720480505513 0.397887424315681 TYROBP/B2M/ITGAM/RBPJ/NR4A2/SLC8A1/NRP1/BTG2/HIF1A/RTN4/TACC1/ATF5/LRP1 13 GO:0048754 branching morphogenesis of an epithelial tube 6/502 151/18722 0.219844413435123 0.397887424315681 PLXND1/CTSZ/NRP1/TGFBR2/ENG/STK4 6 GO:2000181 negative regulation of blood vessel morphogenesis 6/502 151/18722 0.219844413435123 0.397887424315681 STAB1/SPRED1/KLF2/ALOX5/KLF4/STAT1 6 GO:0006536 glutamate metabolic process 2/502 33/18722 0.221328386698076 0.39901212660378 GLUL/GLS 2 GO:0010737 protein kinase A signaling 2/502 33/18722 0.221328386698076 0.39901212660378 LCP1/PRKACB 2 GO:0019362 pyridine nucleotide metabolic process 2/502 33/18722 0.221328386698076 0.39901212660378 PARP9/NAMPT 2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 2/502 33/18722 0.221328386698076 0.39901212660378 LYN/TGFB1 2 GO:0046496 nicotinamide nucleotide metabolic process 2/502 33/18722 0.221328386698076 0.39901212660378 PARP9/NAMPT 2 GO:0071295 cellular response to vitamin 2/502 33/18722 0.221328386698076 0.39901212660378 FOLR2/GAS6 2 GO:1901099 negative regulation of signal transduction in absence of ligand 2/502 33/18722 0.221328386698076 0.39901212660378 HSPA1A/MCL1 2 GO:1901976 regulation of cell cycle checkpoint 2/502 33/18722 0.221328386698076 0.39901212660378 DUSP1/FEM1B 2 GO:1903715 regulation of aerobic respiration 2/502 33/18722 0.221328386698076 0.39901212660378 NUPR1/HIF1A 2 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/502 33/18722 0.221328386698076 0.39901212660378 HSPA1A/MCL1 2 GO:0030901 midbrain development 4/502 90/18722 0.22202899385224 0.399963444532891 NR4A2/ACTB/GNB4/CALM2 4 GO:0046031 ADP metabolic process 4/502 90/18722 0.22202899385224 0.399963444532891 IGF1/NUPR1/STAT3/HIF1A 4 GO:0030509 BMP signaling pathway 6/502 152/18722 0.22415287118047 0.403475168124846 RBPJ/EGR1/ENG/TGFB1/DDX5/SKIL 6 GO:1901343 negative regulation of vasculature development 6/502 152/18722 0.22415287118047 0.403475168124846 STAB1/SPRED1/KLF2/ALOX5/KLF4/STAT1 6 GO:0030199 collagen fibril organization 3/502 61/18722 0.224397966171816 0.403602251753819 RB1/COLGALT1/P4HA1 3 GO:0040014 regulation of multicellular organism growth 3/502 61/18722 0.224397966171816 0.403602251753819 IGF1/LGMN/STAT3 3 GO:0001704 formation of primary germ layer 5/502 121/18722 0.225006079549406 0.404381555553828 ITGB2/DUSP1/KLF4/ETS2/PRKAR1A 5 GO:0045931 positive regulation of mitotic cell cycle 5/502 121/18722 0.225006079549406 0.404381555553828 AIF1/LGMN/RB1/DUSP3/KMT2E 5 GO:0055001 muscle cell development 7/502 184/18722 0.225282071421454 0.404720334910931 IGF1/MEF2A/SLC8A1/GPX1/ENG/PRKAR1A/AKAP13 7 GO:0014033 neural crest cell differentiation 4/502 91/18722 0.227744611595635 0.408668182017614 MEF2C/NRP1/HIF1A/CITED2 4 GO:0051983 regulation of chromosome segregation 4/502 91/18722 0.227744611595635 0.408668182017614 RB1/ATM/DUSP1/PLSCR1 4 GO:0055006 cardiac cell development 4/502 91/18722 0.227744611595635 0.408668182017614 IGF1/MEF2A/SLC8A1/AKAP13 4 GO:0120254 olefinic compound metabolic process 6/502 153/18722 0.228488883080283 0.409844735606587 ALDH1A1/TBXAS1/ALOX5/EGR1/GPX1/DHRS3 6 GO:0006644 phospholipid metabolic process 13/502 383/18722 0.230457322514902 0.412849925679689 CSF1R/ENPP2/PLEK/ATM/SGMS1/PLA2G15/PLSCR1/ETNK1/CEPT1/SPTLC2/PIK3R1/EFR3A/SERINC1 13 GO:0001662 behavioral fear response 2/502 34/18722 0.231278290106724 0.412849925679689 MEF2C/APOE 2 GO:0010614 negative regulation of cardiac muscle hypertrophy 2/502 34/18722 0.231278290106724 0.412849925679689 TNFRSF1B/TNFRSF1A 2 GO:0010661 positive regulation of muscle cell apoptotic process 2/502 34/18722 0.231278290106724 0.412849925679689 SOD2/STK4 2 GO:0032770 positive regulation of monooxygenase activity 2/502 34/18722 0.231278290106724 0.412849925679689 APOE/HIF1A 2 GO:0034383 low-density lipoprotein particle clearance 2/502 34/18722 0.231278290106724 0.412849925679689 CD36/LIPA 2 GO:0035308 negative regulation of protein dephosphorylation 2/502 34/18722 0.231278290106724 0.412849925679689 NCKAP1L/GNAI2 2 GO:0035590 purinergic nucleotide receptor signaling pathway 2/502 34/18722 0.231278290106724 0.412849925679689 GPR34/GNAI2 2 GO:0043276 anoikis 2/502 34/18722 0.231278290106724 0.412849925679689 PDK4/MCL1 2 GO:0051085 chaperone cofactor-dependent protein refolding 2/502 34/18722 0.231278290106724 0.412849925679689 CD74/HSPA1A 2 GO:2000352 negative regulation of endothelial cell apoptotic process 2/502 34/18722 0.231278290106724 0.412849925679689 GAS6/ICAM1 2 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3/502 62/18722 0.231502963081088 0.412849925679689 RB1/ATM/DUSP1 3 GO:0046148 pigment biosynthetic process 3/502 62/18722 0.231502963081088 0.412849925679689 ZEB2/SLC11A2/TSPO 3 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 3/502 62/18722 0.231502963081088 0.412849925679689 EPS15/EPS8/ADAM10 3 GO:1903078 positive regulation of protein localization to plasma membrane 3/502 62/18722 0.231502963081088 0.412849925679689 PRNP/LRP1/PIK3R1 3 GO:0016052 carbohydrate catabolic process 6/502 154/18722 0.232851649012821 0.413973687219443 IGF1/PYGL/NUPR1/STAT3/HIF1A/GAA 6 GO:1902115 regulation of organelle assembly 7/502 186/18722 0.233164343108055 0.413973687219443 CCDC88A/LCP1/HSPA1A/SDCBP/MSN/NUPR1/GSN 7 GO:0070509 calcium ion import 4/502 92/18722 0.23349709522826 0.413973687219443 CCL2/CCL3/PRNP/SLC8A1 4 GO:0061136 regulation of proteasomal protein catabolic process 7/502 187/18722 0.237139794980512 0.413973687219443 APOE/DAB2/HSPA1A/SDCBP/GPX1/NUPR1/HERPUD1 7 GO:0001820 serotonin secretion 1/502 10/18722 0.23803934457495 0.413973687219443 SYK 1 GO:0001865 NK T cell differentiation 1/502 10/18722 0.23803934457495 0.413973687219443 TGFBR2 1 GO:0002084 protein depalmitoylation 1/502 10/18722 0.23803934457495 0.413973687219443 PPT1 1 GO:0002765 immune response-inhibiting signal transduction 1/502 10/18722 0.23803934457495 0.413973687219443 LYN 1 GO:0005984 disaccharide metabolic process 1/502 10/18722 0.23803934457495 0.413973687219443 GAA 1 GO:0006171 cAMP biosynthetic process 1/502 10/18722 0.23803934457495 0.413973687219443 ADCY7 1 GO:0006547 histidine metabolic process 1/502 10/18722 0.23803934457495 0.413973687219443 HNMT 1 GO:0009750 response to fructose 1/502 10/18722 0.23803934457495 0.413973687219443 XBP1 1 GO:0010968 regulation of microtubule nucleation 1/502 10/18722 0.23803934457495 0.413973687219443 HSPA1A 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/502 10/18722 0.23803934457495 0.413973687219443 CD36 1 GO:0016139 glycoside catabolic process 1/502 10/18722 0.23803934457495 0.413973687219443 FUCA1 1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 1/502 10/18722 0.23803934457495 0.413973687219443 P4HA1 1 GO:0021562 vestibulocochlear nerve development 1/502 10/18722 0.23803934457495 0.413973687219443 NRP1 1 GO:0021903 rostrocaudal neural tube patterning 1/502 10/18722 0.23803934457495 0.413973687219443 ATP6AP2 1 GO:0031642 negative regulation of myelination 1/502 10/18722 0.23803934457495 0.413973687219443 CTSC 1 GO:0033131 regulation of glucokinase activity 1/502 10/18722 0.23803934457495 0.413973687219443 RANBP2 1 GO:0034085 establishment of sister chromatid cohesion 1/502 10/18722 0.23803934457495 0.413973687219443 RB1 1 GO:0034756 regulation of iron ion transport 1/502 10/18722 0.23803934457495 0.413973687219443 B2M 1 GO:0035646 endosome to melanosome transport 1/502 10/18722 0.23803934457495 0.413973687219443 CD63 1 GO:0040015 negative regulation of multicellular organism growth 1/502 10/18722 0.23803934457495 0.413973687219443 LGMN 1 GO:0043485 endosome to pigment granule transport 1/502 10/18722 0.23803934457495 0.413973687219443 CD63 1 GO:0044351 macropinocytosis 1/502 10/18722 0.23803934457495 0.413973687219443 PYCARD 1 GO:0044557 relaxation of smooth muscle 1/502 10/18722 0.23803934457495 0.413973687219443 SLC8A1 1 GO:0045835 negative regulation of meiotic nuclear division 1/502 10/18722 0.23803934457495 0.413973687219443 PRKAR1A 1 GO:0045843 negative regulation of striated muscle tissue development 1/502 10/18722 0.23803934457495 0.413973687219443 TGFB1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/502 10/18722 0.23803934457495 0.413973687219443 ATF7IP 1 GO:0048671 negative regulation of collateral sprouting 1/502 10/18722 0.23803934457495 0.413973687219443 SPP1 1 GO:0048672 positive regulation of collateral sprouting 1/502 10/18722 0.23803934457495 0.413973687219443 LRP1 1 GO:0048755 branching morphogenesis of a nerve 1/502 10/18722 0.23803934457495 0.413973687219443 RTN4 1 GO:0048757 pigment granule maturation 1/502 10/18722 0.23803934457495 0.413973687219443 CD63 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/502 10/18722 0.23803934457495 0.413973687219443 CALM2 1 GO:0051351 positive regulation of ligase activity 1/502 10/18722 0.23803934457495 0.413973687219443 TMSB4X 1 GO:0051409 response to nitrosative stress 1/502 10/18722 0.23803934457495 0.413973687219443 ATM 1 GO:0060439 trachea morphogenesis 1/502 10/18722 0.23803934457495 0.413973687219443 TGFBR2 1 GO:0060736 prostate gland growth 1/502 10/18722 0.23803934457495 0.413973687219443 PSAP 1 GO:0060923 cardiac muscle cell fate commitment 1/502 10/18722 0.23803934457495 0.413973687219443 RBPJ 1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 1/502 10/18722 0.23803934457495 0.413973687219443 UCP2 1 GO:0061299 retina vasculature morphogenesis in camera-type eye 1/502 10/18722 0.23803934457495 0.413973687219443 NRP1 1 GO:0070099 regulation of chemokine-mediated signaling pathway 1/502 10/18722 0.23803934457495 0.413973687219443 HIF1A 1 GO:0071233 cellular response to leucine 1/502 10/18722 0.23803934457495 0.413973687219443 SESN1 1 GO:0071421 manganese ion transmembrane transport 1/502 10/18722 0.23803934457495 0.413973687219443 SLC11A2 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/502 10/18722 0.23803934457495 0.413973687219443 EGR1 1 GO:0072378 blood coagulation, fibrin clot formation 1/502 10/18722 0.23803934457495 0.413973687219443 F13A1 1 GO:0090209 negative regulation of triglyceride metabolic process 1/502 10/18722 0.23803934457495 0.413973687219443 APOE 1 GO:0090527 actin filament reorganization 1/502 10/18722 0.23803934457495 0.413973687219443 GSN 1 GO:0097084 vascular associated smooth muscle cell development 1/502 10/18722 0.23803934457495 0.413973687219443 ENG 1 GO:0140059 dendrite arborization 1/502 10/18722 0.23803934457495 0.413973687219443 NRP1 1 GO:1900003 regulation of serine-type endopeptidase activity 1/502 10/18722 0.23803934457495 0.413973687219443 CR1 1 GO:1901203 positive regulation of extracellular matrix assembly 1/502 10/18722 0.23803934457495 0.413973687219443 TGFB1 1 GO:1901524 regulation of mitophagy 1/502 10/18722 0.23803934457495 0.413973687219443 VPS13C 1 GO:1902513 regulation of organelle transport along microtubule 1/502 10/18722 0.23803934457495 0.413973687219443 LAMP1 1 GO:1902571 regulation of serine-type peptidase activity 1/502 10/18722 0.23803934457495 0.413973687219443 CR1 1 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1/502 10/18722 0.23803934457495 0.413973687219443 LYN 1 GO:1905941 positive regulation of gonad development 1/502 10/18722 0.23803934457495 0.413973687219443 CITED2 1 GO:1990253 cellular response to leucine starvation 1/502 10/18722 0.23803934457495 0.413973687219443 SESN1 1 GO:1990535 neuron projection maintenance 1/502 10/18722 0.23803934457495 0.413973687219443 PRNP 1 GO:2000018 regulation of male gonad development 1/502 10/18722 0.23803934457495 0.413973687219443 CITED2 1 GO:2000121 regulation of removal of superoxide radicals 1/502 10/18722 0.23803934457495 0.413973687219443 CD36 1 GO:2000288 positive regulation of myoblast proliferation 1/502 10/18722 0.23803934457495 0.413973687219443 MALAT1 1 GO:2000434 regulation of protein neddylation 1/502 10/18722 0.23803934457495 0.413973687219443 HIF1A 1 GO:2001223 negative regulation of neuron migration 1/502 10/18722 0.23803934457495 0.413973687219443 STAT3 1 GO:2001225 regulation of chloride transport 1/502 10/18722 0.23803934457495 0.413973687219443 PRNP 1 GO:0030239 myofibril assembly 3/502 63/18722 0.238648460249627 0.414565443903408 MEF2A/PRKAR1A/AKAP13 3 GO:0099601 regulation of neurotransmitter receptor activity 3/502 63/18722 0.238648460249627 0.414565443903408 MEF2C/CCL2/IFNGR2 3 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3/502 63/18722 0.238648460249627 0.414565443903408 RB1/ATM/DUSP1 3 GO:0034329 cell junction assembly 14/502 420/18722 0.239217760628825 0.415358436482863 MEF2C/PLXND1/VMP1/PEAK1/MTDH/PECAM1/NRP1/ACTB/IQGAP1/SDCBP/DUSP3/LRP1/MACF1/PLXNB2 14 GO:0090398 cellular senescence 4/502 93/18722 0.239284529448082 0.415358436482863 B2M/SPI1/NAMPT/ATM 4 GO:0008654 phospholipid biosynthetic process 9/502 253/18722 0.240004569091204 0.416452039240776 ATM/SGMS1/PLSCR1/ETNK1/CEPT1/SPTLC2/PIK3R1/EFR3A/SERINC1 9 GO:0002209 behavioral defense response 2/502 35/18722 0.241255427710307 0.416591119293722 MEF2C/APOE 2 GO:0003298 physiological muscle hypertrophy 2/502 35/18722 0.241255427710307 0.416591119293722 IGF1/AKAP13 2 GO:0003301 physiological cardiac muscle hypertrophy 2/502 35/18722 0.241255427710307 0.416591119293722 IGF1/AKAP13 2 GO:0006471 protein ADP-ribosylation 2/502 35/18722 0.241255427710307 0.416591119293722 PARP14/PARP9 2 GO:0010664 negative regulation of striated muscle cell apoptotic process 2/502 35/18722 0.241255427710307 0.416591119293722 JAK2/NUPR1 2 GO:0010837 regulation of keratinocyte proliferation 2/502 35/18722 0.241255427710307 0.416591119293722 ZFP36L1/ZFP36 2 GO:0032232 negative regulation of actin filament bundle assembly 2/502 35/18722 0.241255427710307 0.416591119293722 WAS/PIK3R1 2 GO:0032350 regulation of hormone metabolic process 2/502 35/18722 0.241255427710307 0.416591119293722 EGR1/HIF1A 2 GO:0035633 maintenance of blood-brain barrier 2/502 35/18722 0.241255427710307 0.416591119293722 PECAM1/ACTB 2 GO:0043243 positive regulation of protein-containing complex disassembly 2/502 35/18722 0.241255427710307 0.416591119293722 PLEK/SETX 2 GO:0045907 positive regulation of vasoconstriction 2/502 35/18722 0.241255427710307 0.416591119293722 ICAM1/TBXAS1 2 GO:0060236 regulation of mitotic spindle organization 2/502 35/18722 0.241255427710307 0.416591119293722 HSPA1A/CLTC 2 GO:0061049 cell growth involved in cardiac muscle cell development 2/502 35/18722 0.241255427710307 0.416591119293722 IGF1/AKAP13 2 GO:0001764 neuron migration 6/502 156/18722 0.24165422265495 0.417124042537985 MEF2C/GAS6/NR4A2/NRP1/STAT3/PLXNB2 6 GO:0018210 peptidyl-threonine modification 5/502 125/18722 0.244808840049104 0.422292651322852 SPRED1/TGFBR2/TGFB1/CAB39/CALM2 5 GO:0002042 cell migration involved in sprouting angiogenesis 4/502 94/18722 0.245105008387777 0.422292651322852 SPRED1/NRP1/KLF4/NR4A1 4 GO:0010389 regulation of G2/M transition of mitotic cell cycle 4/502 94/18722 0.245105008387777 0.422292651322852 ATM/NABP1/TAOK3/TAOK1 4 GO:1903035 negative regulation of response to wounding 4/502 94/18722 0.245105008387777 0.422292651322852 SPP1/APOE/SERPING1/ALOX5 4 GO:1990830 cellular response to leukemia inhibitory factor 4/502 94/18722 0.245105008387777 0.422292651322852 ICAM1/KLF4/MAT2A/EPS8 4 GO:0006749 glutathione metabolic process 3/502 64/18722 0.245830877736008 0.422756000151217 HPGDS/GPX1/MGST2 3 GO:0046854 phosphatidylinositol phosphate biosynthetic process 3/502 64/18722 0.245830877736008 0.422756000151217 ATM/PIK3R1/EFR3A 3 GO:0048857 neural nucleus development 3/502 64/18722 0.245830877736008 0.422756000151217 ACTB/GNB4/CALM2 3 GO:0055002 striated muscle cell development 3/502 64/18722 0.245830877736008 0.422756000151217 MEF2A/PRKAR1A/AKAP13 3 GO:1903018 regulation of glycoprotein metabolic process 3/502 64/18722 0.245830877736008 0.422756000151217 IGF1/ITM2B/CST3 3 GO:1903311 regulation of mRNA metabolic process 10/502 288/18722 0.246254955182372 0.423327916266686 ZFP36L1/CELF2/ZFP36/BTG2/VIM/ZFP36L2/QKI/MBNL1/DDX17/DDX5 10 GO:0043547 positive regulation of GTPase activity 9/502 255/18722 0.246890389128289 0.424262607766517 CCL2/CCL3/ADAP2/ICAM1/CCL4/RGS1/PREX1/RGS10/GPR65 9 GO:0046390 ribose phosphate biosynthetic process 7/502 190/18722 0.249196345159975 0.428066205982193 TMSB4X/PDK4/PYGL/PPT1/TGFB1/STAT3/ADCY7 7 GO:0006631 fatty acid metabolic process 13/502 390/18722 0.249741642213234 0.428578173547568 HPGDS/CD74/CD36/ALOX5AP/TBXAS1/ALOX5/ASAH1/PDK4/XBP1/PLA2G15/GPX1/QKI/TNFRSF1A 13 GO:0006942 regulation of striated muscle contraction 4/502 95/18722 0.250956637047109 0.428578173547568 ATP1B1/SLC8A1/NR4A1/CALM2 4 GO:0008593 regulation of Notch signaling pathway 4/502 95/18722 0.250956637047109 0.428578173547568 EGFL7/BMP2K/STAT3/ADAM10 4 GO:0045666 positive regulation of neuron differentiation 4/502 95/18722 0.250956637047109 0.428578173547568 MEF2C/TCF4/TIMP2/TCF12 4 GO:1901379 regulation of potassium ion transmembrane transport 4/502 95/18722 0.250956637047109 0.428578173547568 ATP1B1/PRNP/CD63/CAB39 4 GO:1990823 response to leukemia inhibitory factor 4/502 95/18722 0.250956637047109 0.428578173547568 ICAM1/KLF4/MAT2A/EPS8 4 GO:0002691 regulation of cellular extravasation 2/502 36/18722 0.251251204982134 0.428578173547568 ICAM1/PTGER4 2 GO:0008207 C21-steroid hormone metabolic process 2/502 36/18722 0.251251204982134 0.428578173547568 EGR1/TSPO 2 GO:0009225 nucleotide-sugar metabolic process 2/502 36/18722 0.251251204982134 0.428578173547568 MGAT1/GNPDA1 2 GO:0010092 specification of animal organ identity 2/502 36/18722 0.251251204982134 0.428578173547568 MEF2C/RBPJ 2 GO:0010923 negative regulation of phosphatase activity 2/502 36/18722 0.251251204982134 0.428578173547568 NCKAP1L/GNAI2 2 GO:0014741 negative regulation of muscle hypertrophy 2/502 36/18722 0.251251204982134 0.428578173547568 TNFRSF1B/TNFRSF1A 2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 2/502 36/18722 0.251251204982134 0.428578173547568 CCDC88A/NCF1 2 GO:0060251 regulation of glial cell proliferation 2/502 36/18722 0.251251204982134 0.428578173547568 LYN/TSPO 2 GO:0086010 membrane depolarization during action potential 2/502 36/18722 0.251251204982134 0.428578173547568 SCN9A/SLC8A1 2 GO:0010965 regulation of mitotic sister chromatid separation 3/502 65/18722 0.253046699043008 0.428578173547568 RB1/ATM/DUSP1 3 GO:0015909 long-chain fatty acid transport 3/502 65/18722 0.253046699043008 0.428578173547568 APOE/CD36/SYK 3 GO:0038034 signal transduction in absence of ligand 3/502 65/18722 0.253046699043008 0.428578173547568 HSPA1A/FOXO3/MCL1 3 GO:0044784 metaphase/anaphase transition of cell cycle 3/502 65/18722 0.253046699043008 0.428578173547568 RB1/ATM/DUSP1 3 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 3/502 65/18722 0.253046699043008 0.428578173547568 HSPA1A/FOXO3/MCL1 3 GO:0008544 epidermis development 11/502 324/18722 0.254268298177264 0.428578173547568 HLA-DRB1/TXNIP/ZFP36L1/RBPJ/ZFP36/ADAM9/ASAH1/WAS/KLF4/SLC4A7/STK4 11 GO:0051224 negative regulation of protein transport 5/502 127/18722 0.254878265372991 0.428578173547568 APOE/CD36/RSAD2/UCP2/SP100 5 GO:0035966 response to topologically incorrect protein 6/502 159/18722 0.25503852749473 0.428578173547568 HSPA1A/XBP1/TMBIM6/TRAM1/PIK3R1/HERPUD1 6 GO:0046486 glycerolipid metabolic process 13/502 392/18722 0.255360278972156 0.428578173547568 CSF1R/ENPP2/APOE/PLEK/ATM/PLA2G15/PLSCR1/GPX1/ETNK1/CEPT1/PIK3R1/EFR3A/SERINC1 13 GO:0035282 segmentation 4/502 96/18722 0.25683753265953 0.428578173547568 MAFB/RBPJ/NRP1/ABI1 4 GO:0042158 lipoprotein biosynthetic process 4/502 96/18722 0.25683753265953 0.428578173547568 APOE/ABCA1/ATG7/GLUL 4 GO:0042632 cholesterol homeostasis 4/502 96/18722 0.25683753265953 0.428578173547568 APOE/NPC2/ABCA1/XBP1 4 GO:0051304 chromosome separation 4/502 96/18722 0.25683753265953 0.428578173547568 RB1/ATM/DUSP1/PLSCR1 4 GO:0051052 regulation of DNA metabolic process 12/502 359/18722 0.258034004929653 0.428578173547568 CD28/PTPRC/SPI1/ARRB2/PARP9/ATM/DUSP1/ACTR2/DTX3L/WAS/KLF4/TGFB1 12 GO:0001787 natural killer cell proliferation 1/502 11/18722 0.258480999610401 0.428578173547568 HLA-E 1 GO:0001967 suckling behavior 1/502 11/18722 0.258480999610401 0.428578173547568 GLS 1 GO:0002645 positive regulation of tolerance induction 1/502 11/18722 0.258480999610401 0.428578173547568 TGFBR2 1 GO:0002732 positive regulation of dendritic cell cytokine production 1/502 11/18722 0.258480999610401 0.428578173547568 CLEC7A 1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/502 11/18722 0.258480999610401 0.428578173547568 PDK4 1 GO:0006707 cholesterol catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 APOE 1 GO:0009155 purine deoxyribonucleotide catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 SAMHD1 1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/502 11/18722 0.258480999610401 0.428578173547568 ATP1B1 1 GO:0010887 negative regulation of cholesterol storage 1/502 11/18722 0.258480999610401 0.428578173547568 ABCA1 1 GO:0016127 sterol catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 APOE 1 GO:0021561 facial nerve development 1/502 11/18722 0.258480999610401 0.428578173547568 NRP1 1 GO:0021604 cranial nerve structural organization 1/502 11/18722 0.258480999610401 0.428578173547568 NRP1 1 GO:0021610 facial nerve morphogenesis 1/502 11/18722 0.258480999610401 0.428578173547568 NRP1 1 GO:0021889 olfactory bulb interneuron differentiation 1/502 11/18722 0.258480999610401 0.428578173547568 ATF5 1 GO:0033210 leptin-mediated signaling pathway 1/502 11/18722 0.258480999610401 0.428578173547568 STAT3 1 GO:0033625 positive regulation of integrin activation 1/502 11/18722 0.258480999610401 0.428578173547568 PLEK 1 GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/502 11/18722 0.258480999610401 0.428578173547568 FERMT3 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/502 11/18722 0.258480999610401 0.428578173547568 KLF4 1 GO:0039530 MDA-5 signaling pathway 1/502 11/18722 0.258480999610401 0.428578173547568 IFIH1 1 GO:0042135 neurotransmitter catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 HNMT 1 GO:0042416 dopamine biosynthetic process 1/502 11/18722 0.258480999610401 0.428578173547568 NR4A2 1 GO:0042447 hormone catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 SPP1 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/502 11/18722 0.258480999610401 0.428578173547568 HIF1A 1 GO:0045628 regulation of T-helper 2 cell differentiation 1/502 11/18722 0.258480999610401 0.428578173547568 CD86 1 GO:0045793 positive regulation of cell size 1/502 11/18722 0.258480999610401 0.428578173547568 TMEM123 1 GO:0046349 amino sugar biosynthetic process 1/502 11/18722 0.258480999610401 0.428578173547568 GNPDA1 1 GO:0048103 somatic stem cell division 1/502 11/18722 0.258480999610401 0.428578173547568 ZFP36L2 1 GO:0048635 negative regulation of muscle organ development 1/502 11/18722 0.258480999610401 0.428578173547568 TGFB1 1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1/502 11/18722 0.258480999610401 0.428578173547568 CYFIP1 1 GO:0051673 membrane disruption in other organism 1/502 11/18722 0.258480999610401 0.428578173547568 MPEG1 1 GO:0055015 ventricular cardiac muscle cell development 1/502 11/18722 0.258480999610401 0.428578173547568 MEF2A 1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/502 11/18722 0.258480999610401 0.428578173547568 CALM2 1 GO:0060379 cardiac muscle cell myoblast differentiation 1/502 11/18722 0.258480999610401 0.428578173547568 RBPJ 1 GO:0060433 bronchus development 1/502 11/18722 0.258480999610401 0.428578173547568 TGFBR2 1 GO:0061314 Notch signaling involved in heart development 1/502 11/18722 0.258480999610401 0.428578173547568 RBPJ 1 GO:0070243 regulation of thymocyte apoptotic process 1/502 11/18722 0.258480999610401 0.428578173547568 HIF1A 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/502 11/18722 0.258480999610401 0.428578173547568 KLF4 1 GO:0070778 L-aspartate transmembrane transport 1/502 11/18722 0.258480999610401 0.428578173547568 SLC1A3 1 GO:0071044 histone mRNA catabolic process 1/502 11/18722 0.258480999610401 0.428578173547568 ATM 1 GO:0071313 cellular response to caffeine 1/502 11/18722 0.258480999610401 0.428578173547568 SLC8A1 1 GO:0071492 cellular response to UV-A 1/502 11/18722 0.258480999610401 0.428578173547568 TIMP1 1 GO:0071609 chemokine (C-C motif) ligand 5 production 1/502 11/18722 0.258480999610401 0.428578173547568 SIRPA 1 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 1/502 11/18722 0.258480999610401 0.428578173547568 SIRPA 1 GO:0071679 commissural neuron axon guidance 1/502 11/18722 0.258480999610401 0.428578173547568 NRP1 1 GO:0071888 macrophage apoptotic process 1/502 11/18722 0.258480999610401 0.428578173547568 MEF2C 1 GO:0072110 glomerular mesangial cell proliferation 1/502 11/18722 0.258480999610401 0.428578173547568 EGR1 1 GO:0090084 negative regulation of inclusion body assembly 1/502 11/18722 0.258480999610401 0.428578173547568 HSPA1A 1 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 1/502 11/18722 0.258480999610401 0.428578173547568 ATF7IP 1 GO:0090649 response to oxygen-glucose deprivation 1/502 11/18722 0.258480999610401 0.428578173547568 NAMPT 1 GO:0099022 vesicle tethering 1/502 11/18722 0.258480999610401 0.428578173547568 FAM91A1 1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 1/502 11/18722 0.258480999610401 0.428578173547568 SLC8A1 1 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/502 11/18722 0.258480999610401 0.428578173547568 GNAI2 1 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/502 11/18722 0.258480999610401 0.428578173547568 CHCHD10 1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 1/502 11/18722 0.258480999610401 0.428578173547568 N4BP2L2 1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1/502 11/18722 0.258480999610401 0.428578173547568 CALM2 1 GO:1901862 negative regulation of muscle tissue development 1/502 11/18722 0.258480999610401 0.428578173547568 TGFB1 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/502 11/18722 0.258480999610401 0.428578173547568 N4BP2L2 1 GO:1902065 response to L-glutamate 1/502 11/18722 0.258480999610401 0.428578173547568 TMBIM6 1 GO:1902667 regulation of axon guidance 1/502 11/18722 0.258480999610401 0.428578173547568 NRP1 1 GO:1903299 regulation of hexokinase activity 1/502 11/18722 0.258480999610401 0.428578173547568 RANBP2 1 GO:1904181 positive regulation of membrane depolarization 1/502 11/18722 0.258480999610401 0.428578173547568 TSPO 1 GO:1904321 response to forskolin 1/502 11/18722 0.258480999610401 0.428578173547568 AHR 1 GO:1904322 cellular response to forskolin 1/502 11/18722 0.258480999610401 0.428578173547568 AHR 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/502 11/18722 0.258480999610401 0.428578173547568 TLR4 1 GO:1905050 positive regulation of metallopeptidase activity 1/502 11/18722 0.258480999610401 0.428578173547568 STAT3 1 GO:1990773 matrix metallopeptidase secretion 1/502 11/18722 0.258480999610401 0.428578173547568 TLR4 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/502 11/18722 0.258480999610401 0.428578173547568 PRKAR1A 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/502 11/18722 0.258480999610401 0.428578173547568 HIF1A 1 GO:0035637 multicellular organismal signaling 6/502 160/18722 0.259544821173689 0.430187869132743 SCN9A/ATP1B1/TYMP/MEF2A/SLC8A1/CALM2 6 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 3/502 66/18722 0.260292472929326 0.430251706002594 CD28/PTPRC/TGFB1 3 GO:0006303 double-strand break repair via nonhomologous end joining 3/502 66/18722 0.260292472929326 0.430251706002594 PARP9/ATM/DTX3L 3 GO:0016444 somatic cell DNA recombination 3/502 66/18722 0.260292472929326 0.430251706002594 CD28/PTPRC/TGFB1 3 GO:0030193 regulation of blood coagulation 3/502 66/18722 0.260292472929326 0.430251706002594 APOE/CD36/SERPING1 3 GO:0042446 hormone biosynthetic process 3/502 66/18722 0.260292472929326 0.430251706002594 EGR1/TSPO/HIF1A 3 GO:2000573 positive regulation of DNA biosynthetic process 3/502 66/18722 0.260292472929326 0.430251706002594 ARRB2/ATM/KLF4 3 GO:0003016 respiratory system process 2/502 37/18722 0.261257466960935 0.430251706002594 GLS/GAA 2 GO:0006904 vesicle docking involved in exocytosis 2/502 37/18722 0.261257466960935 0.430251706002594 PLEK/RAB8B 2 GO:0014904 myotube cell development 2/502 37/18722 0.261257466960935 0.430251706002594 IGF1/GPX1 2 GO:0016202 regulation of striated muscle tissue development 2/502 37/18722 0.261257466960935 0.430251706002594 MEF2C/TGFB1 2 GO:0021532 neural tube patterning 2/502 37/18722 0.261257466960935 0.430251706002594 PRKACB/ATP6AP2 2 GO:0030513 positive regulation of BMP signaling pathway 2/502 37/18722 0.261257466960935 0.430251706002594 RBPJ/ENG 2 GO:0033363 secretory granule organization 2/502 37/18722 0.261257466960935 0.430251706002594 SRGN/ABCA1 2 GO:0042401 cellular biogenic amine biosynthetic process 2/502 37/18722 0.261257466960935 0.430251706002594 NR4A2/SAT1 2 GO:0045616 regulation of keratinocyte differentiation 2/502 37/18722 0.261257466960935 0.430251706002594 ZFP36L1/ZFP36 2 GO:0060428 lung epithelium development 2/502 37/18722 0.261257466960935 0.430251706002594 RBPJ/KLF2 2 GO:0071542 dopaminergic neuron differentiation 2/502 37/18722 0.261257466960935 0.430251706002594 NR4A2/HIF1A 2 GO:0097484 dendrite extension 2/502 37/18722 0.261257466960935 0.430251706002594 ITSN2/CYFIP1 2 GO:0035335 peptidyl-tyrosine dephosphorylation 4/502 97/18722 0.262745825994173 0.432394945232673 PTPRC/DUSP1/PTPN6/DUSP3 4 GO:0055092 sterol homeostasis 4/502 97/18722 0.262745825994173 0.432394945232673 APOE/NPC2/ABCA1/XBP1 4 GO:0007093 mitotic cell cycle checkpoint signaling 5/502 129/18722 0.265047103217173 0.436026991281167 ATM/DUSP1/NABP1/TAOK3/TAOK1 5 GO:0045137 development of primary sexual characteristics 8/502 227/18722 0.265466218301102 0.436561224977212 ICAM1/ARRB2/LHFPL2/FOXO3/NRIP1/NUPR1/NCOA4/CITED2 8 GO:0051306 mitotic sister chromatid separation 3/502 67/18722 0.267564815009249 0.439699763492997 RB1/ATM/DUSP1 3 GO:0061077 chaperone-mediated protein folding 3/502 67/18722 0.267564815009249 0.439699763492997 CD74/FKBP5/HSPA1A 3 GO:0061337 cardiac conduction 4/502 98/18722 0.268679662594417 0.44137504231597 ATP1B1/MEF2A/SLC8A1/CALM2 4 GO:0030073 insulin secretion 7/502 195/18722 0.269688722447963 0.442835009600091 HLA-DRB1/ALOX5/JAK2/GLUL/UCP2/HIF1A/LRP1 7 GO:0043467 regulation of generation of precursor metabolites and energy 5/502 130/18722 0.270165854019883 0.442835009600091 IGF1/NUPR1/STAT3/HIF1A/IFNAR1 5 GO:0051028 mRNA transport 5/502 130/18722 0.270165854019883 0.442835009600091 ZFP36L1/MX2/ZFP36/QKI/RANBP2 5 GO:0007094 mitotic spindle assembly checkpoint signaling 2/502 38/18722 0.271266480936981 0.442835009600091 ATM/DUSP1 2 GO:0009309 amine biosynthetic process 2/502 38/18722 0.271266480936981 0.442835009600091 NR4A2/SAT1 2 GO:0010613 positive regulation of cardiac muscle hypertrophy 2/502 38/18722 0.271266480936981 0.442835009600091 IGF1/MEF2A 2 GO:0032717 negative regulation of interleukin-8 production 2/502 38/18722 0.271266480936981 0.442835009600091 TMSB4X/KLF4 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/502 38/18722 0.271266480936981 0.442835009600091 SOD2/ENG 2 GO:0042491 inner ear auditory receptor cell differentiation 2/502 38/18722 0.271266480936981 0.442835009600091 RBPJ/SLC4A7 2 GO:0042596 fear response 2/502 38/18722 0.271266480936981 0.442835009600091 MEF2C/APOE 2 GO:0071173 spindle assembly checkpoint signaling 2/502 38/18722 0.271266480936981 0.442835009600091 ATM/DUSP1 2 GO:0071174 mitotic spindle checkpoint signaling 2/502 38/18722 0.271266480936981 0.442835009600091 ATM/DUSP1 2 GO:0072524 pyridine-containing compound metabolic process 2/502 38/18722 0.271266480936981 0.442835009600091 PARP9/NAMPT 2 GO:0050657 nucleic acid transport 6/502 163/18722 0.273186821136171 0.442835009600091 ZFP36L1/MX2/ZFP36/TGFBR2/QKI/RANBP2 6 GO:0050658 RNA transport 6/502 163/18722 0.273186821136171 0.442835009600091 ZFP36L1/MX2/ZFP36/TGFBR2/QKI/RANBP2 6 GO:0045664 regulation of neuron differentiation 7/502 196/18722 0.273841485312271 0.442835009600091 MEF2C/TCF4/B2M/TIMP2/FOXO3/TCF12/ZFHX3 7 GO:0000045 autophagosome assembly 4/502 99/18722 0.274637203954274 0.442835009600091 VMP1/ATG7/NUPR1/STX12 4 GO:0006165 nucleoside diphosphate phosphorylation 4/502 99/18722 0.274637203954274 0.442835009600091 IGF1/NUPR1/STAT3/HIF1A 4 GO:0060291 long-term synaptic potentiation 4/502 99/18722 0.274637203954274 0.442835009600091 TYROBP/LGMN/APOE/PRNP 4 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 3/502 68/18722 0.274860409152133 0.442835009600091 TMSB4X/TGFB1/STAT3 3 GO:0010812 negative regulation of cell-substrate adhesion 3/502 68/18722 0.274860409152133 0.442835009600091 LGALS1/LRP1/PIK3R1 3 GO:0051926 negative regulation of calcium ion transport 3/502 68/18722 0.274860409152133 0.442835009600091 ICAM1/TMBIM6/CALM2 3 GO:0061912 selective autophagy 3/502 68/18722 0.274860409152133 0.442835009600091 VPS13C/WDFY3/SPTLC2 3 GO:1900046 regulation of hemostasis 3/502 68/18722 0.274860409152133 0.442835009600091 APOE/CD36/SERPING1 3 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5/502 131/18722 0.275305926832714 0.442835009600091 SPRED1/HSPA1A/SNX6/LRP1/SKIL 5 GO:1904950 negative regulation of establishment of protein localization 5/502 131/18722 0.275305926832714 0.442835009600091 APOE/CD36/RSAD2/UCP2/SP100 5 GO:0001821 histamine secretion 1/502 12/18722 0.278375315157169 0.442835009600091 LYN 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/502 12/18722 0.278375315157169 0.442835009600091 SOD2 1 GO:0002674 negative regulation of acute inflammatory response 1/502 12/18722 0.278375315157169 0.442835009600091 FCGR2B 1 GO:0002903 negative regulation of B cell apoptotic process 1/502 12/18722 0.278375315157169 0.442835009600091 CD74 1 GO:0003207 cardiac chamber formation 1/502 12/18722 0.278375315157169 0.442835009600091 MEF2C 1 GO:0003306 Wnt signaling pathway involved in heart development 1/502 12/18722 0.278375315157169 0.442835009600091 RBPJ 1 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 1/502 12/18722 0.278375315157169 0.442835009600091 TYMP 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/502 12/18722 0.278375315157169 0.442835009600091 LRP1 1 GO:0021559 trigeminal nerve development 1/502 12/18722 0.278375315157169 0.442835009600091 NRP1 1 GO:0031223 auditory behavior 1/502 12/18722 0.278375315157169 0.442835009600091 SLC1A3 1 GO:0031453 positive regulation of heterochromatin assembly 1/502 12/18722 0.278375315157169 0.442835009600091 ATF7IP 1 GO:0032621 interleukin-18 production 1/502 12/18722 0.278375315157169 0.442835009600091 CD84 1 GO:0032661 regulation of interleukin-18 production 1/502 12/18722 0.278375315157169 0.442835009600091 CD84 1 GO:0032823 regulation of natural killer cell differentiation 1/502 12/18722 0.278375315157169 0.442835009600091 GAS6 1 GO:0033523 histone H2B ubiquitination 1/502 12/18722 0.278375315157169 0.442835009600091 DTX3L 1 GO:0034086 maintenance of sister chromatid cohesion 1/502 12/18722 0.278375315157169 0.442835009600091 RB1 1 GO:0034088 maintenance of mitotic sister chromatid cohesion 1/502 12/18722 0.278375315157169 0.442835009600091 RB1 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/502 12/18722 0.278375315157169 0.442835009600091 NINJ1 1 GO:0034333 adherens junction assembly 1/502 12/18722 0.278375315157169 0.442835009600091 ACTB 1 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1/502 12/18722 0.278375315157169 0.442835009600091 APOE 1 GO:0034372 very-low-density lipoprotein particle remodeling 1/502 12/18722 0.278375315157169 0.442835009600091 APOE 1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 1/502 12/18722 0.278375315157169 0.442835009600091 SYK 1 GO:0038203 TORC2 signaling 1/502 12/18722 0.278375315157169 0.442835009600091 NCKAP1L 1 GO:0042762 regulation of sulfur metabolic process 1/502 12/18722 0.278375315157169 0.442835009600091 PDK4 1 GO:0043129 surfactant homeostasis 1/502 12/18722 0.278375315157169 0.442835009600091 OAS1 1 GO:0043476 pigment accumulation 1/502 12/18722 0.278375315157169 0.442835009600091 CD63 1 GO:0043482 cellular pigment accumulation 1/502 12/18722 0.278375315157169 0.442835009600091 CD63 1 GO:0048548 regulation of pinocytosis 1/502 12/18722 0.278375315157169 0.442835009600091 PPT1 1 GO:0048934 peripheral nervous system neuron differentiation 1/502 12/18722 0.278375315157169 0.442835009600091 RUNX1 1 GO:0048935 peripheral nervous system neuron development 1/502 12/18722 0.278375315157169 0.442835009600091 RUNX1 1 GO:0051095 regulation of helicase activity 1/502 12/18722 0.278375315157169 0.442835009600091 IFIT1 1 GO:0051340 regulation of ligase activity 1/502 12/18722 0.278375315157169 0.442835009600091 TMSB4X 1 GO:0051549 positive regulation of keratinocyte migration 1/502 12/18722 0.278375315157169 0.442835009600091 ADAM9 1 GO:0051639 actin filament network formation 1/502 12/18722 0.278375315157169 0.442835009600091 LCP1 1 GO:0060009 Sertoli cell development 1/502 12/18722 0.278375315157169 0.442835009600091 ICAM1 1 GO:0060019 radial glial cell differentiation 1/502 12/18722 0.278375315157169 0.442835009600091 STAT3 1 GO:0060123 regulation of growth hormone secretion 1/502 12/18722 0.278375315157169 0.442835009600091 ITSN1 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/502 12/18722 0.278375315157169 0.442835009600091 LRP1 1 GO:0060442 branching involved in prostate gland morphogenesis 1/502 12/18722 0.278375315157169 0.442835009600091 FEM1B 1 GO:0060453 regulation of gastric acid secretion 1/502 12/18722 0.278375315157169 0.442835009600091 SGK1 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/502 12/18722 0.278375315157169 0.442835009600091 PRKACB 1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/502 12/18722 0.278375315157169 0.442835009600091 IGF1 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/502 12/18722 0.278375315157169 0.442835009600091 CITED2 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/502 12/18722 0.278375315157169 0.442835009600091 CITED2 1 GO:0061517 macrophage proliferation 1/502 12/18722 0.278375315157169 0.442835009600091 CSF1R 1 GO:0070493 thrombin-activated receptor signaling pathway 1/502 12/18722 0.278375315157169 0.442835009600091 PLEK 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/502 12/18722 0.278375315157169 0.442835009600091 KLF4 1 GO:0071107 response to parathyroid hormone 1/502 12/18722 0.278375315157169 0.442835009600091 MEF2C 1 GO:0071472 cellular response to salt stress 1/502 12/18722 0.278375315157169 0.442835009600091 ZFP36L1 1 GO:0071635 negative regulation of transforming growth factor beta production 1/502 12/18722 0.278375315157169 0.442835009600091 TYROBP 1 GO:0072015 glomerular visceral epithelial cell development 1/502 12/18722 0.278375315157169 0.442835009600091 IQGAP1 1 GO:0072182 regulation of nephron tubule epithelial cell differentiation 1/502 12/18722 0.278375315157169 0.442835009600091 STAT1 1 GO:0072584 caveolin-mediated endocytosis 1/502 12/18722 0.278375315157169 0.442835009600091 ITSN1 1 GO:0090557 establishment of endothelial intestinal barrier 1/502 12/18722 0.278375315157169 0.442835009600091 ICAM1 1 GO:0090677 reversible differentiation 1/502 12/18722 0.278375315157169 0.442835009600091 SOD2 1 GO:0097152 mesenchymal cell apoptotic process 1/502 12/18722 0.278375315157169 0.442835009600091 HIF1A 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/502 12/18722 0.278375315157169 0.442835009600091 ACTB 1 GO:0120263 positive regulation of heterochromatin organization 1/502 12/18722 0.278375315157169 0.442835009600091 ATF7IP 1 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 1/502 12/18722 0.278375315157169 0.442835009600091 FOXO3 1 GO:1901503 ether biosynthetic process 1/502 12/18722 0.278375315157169 0.442835009600091 ALOX5 1 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 1/502 12/18722 0.278375315157169 0.442835009600091 VMP1 1 GO:1903332 regulation of protein folding 1/502 12/18722 0.278375315157169 0.442835009600091 GRN 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/502 12/18722 0.278375315157169 0.442835009600091 HIF1A 1 GO:1990034 calcium ion export across plasma membrane 1/502 12/18722 0.278375315157169 0.442835009600091 CALM2 1 GO:2000035 regulation of stem cell division 1/502 12/18722 0.278375315157169 0.442835009600091 EVI2B 1 GO:2001214 positive regulation of vasculogenesis 1/502 12/18722 0.278375315157169 0.442835009600091 RIN2 1 GO:0019218 regulation of steroid metabolic process 4/502 100/18722 0.28061662863388 0.445907907728818 APOE/ASAH1/EGR1/TSPO 4 GO:0044728 DNA methylation or demethylation 4/502 100/18722 0.28061662863388 0.445907907728818 SPI1/FOS/ATF7IP/KMT2E 4 GO:0010463 mesenchymal cell proliferation 2/502 39/18722 0.281270919747663 0.445907907728818 TGFBR2/STAT1 2 GO:0014742 positive regulation of muscle hypertrophy 2/502 39/18722 0.281270919747663 0.445907907728818 IGF1/MEF2A 2 GO:0016572 histone phosphorylation 2/502 39/18722 0.281270919747663 0.445907907728818 JAK2/ATM 2 GO:0031577 spindle checkpoint signaling 2/502 39/18722 0.281270919747663 0.445907907728818 ATM/DUSP1 2 GO:0051084 'de novo' posttranslational protein folding 2/502 39/18722 0.281270919747663 0.445907907728818 CD74/HSPA1A 2 GO:0071548 response to dexamethasone 2/502 39/18722 0.281270919747663 0.445907907728818 ICAM1/FOXO3 2 GO:0090224 regulation of spindle organization 2/502 39/18722 0.281270919747663 0.445907907728818 HSPA1A/CLTC 2 GO:1901861 regulation of muscle tissue development 2/502 39/18722 0.281270919747663 0.445907907728818 MEF2C/TGFB1 2 GO:0009145 purine nucleoside triphosphate biosynthetic process 3/502 69/18722 0.28217600869302 0.446577562851149 TMSB4X/TGFB1/STAT3 3 GO:0045669 positive regulation of osteoblast differentiation 3/502 69/18722 0.28217600869302 0.446577562851149 MEF2C/IGF1/ATP6AP1 3 GO:0051966 regulation of synaptic transmission, glutamatergic 3/502 69/18722 0.28217600869302 0.446577562851149 MEF2C/CCL2/GLUL 3 GO:0060193 positive regulation of lipase activity 3/502 69/18722 0.28217600869302 0.446577562851149 CD86/C5AR1/GNA13 3 GO:1904377 positive regulation of protein localization to cell periphery 3/502 69/18722 0.28217600869302 0.446577562851149 PRNP/LRP1/PIK3R1 3 GO:0071772 response to BMP 6/502 165/18722 0.282375890588098 0.446588331576254 RBPJ/EGR1/ENG/TGFB1/DDX5/SKIL 6 GO:0071773 cellular response to BMP stimulus 6/502 165/18722 0.282375890588098 0.446588331576254 RBPJ/EGR1/ENG/TGFB1/DDX5/SKIL 6 GO:0006402 mRNA catabolic process 8/502 232/18722 0.284671929702252 0.450065737116411 ZFP36L1/ZFP36/HSPA1A/ATM/BTG2/VIM/ZFP36L2/DDX5 8 GO:0016050 vesicle organization 10/502 300/18722 0.2862048762778 0.452334731008234 ZEB2/SRGN/ABCA1/EPS15/SDCBP/STX7/SAMD9/DNAJC13/STX12/RAB8B 10 GO:0046939 nucleotide phosphorylation 4/502 101/18722 0.286616133315359 0.452829997512586 IGF1/NUPR1/STAT3/HIF1A 4 GO:0060415 muscle tissue morphogenesis 3/502 70/18722 0.289508437465233 0.457243438618698 RBPJ/ENG/TGFB1 3 GO:0045216 cell-cell junction organization 7/502 200/18722 0.290613206184987 0.458294744909657 CSF1R/MTSS1/MTDH/PECAM1/ACTB/TGFB1/ADAM10 7 GO:0008277 regulation of G protein-coupled receptor signaling pathway 5/502 134/18722 0.290842409194512 0.458294744909657 PLEK/RGS1/ARRB2/RGS10/GNAI2 5 GO:0050804 modulation of chemical synaptic transmission 14/502 439/18722 0.29123218387721 0.458294744909657 MEF2C/CCL2/TYROBP/LGMN/APOE/SRGN/ARRB2/PRNP/JAK2/GLUL/CYFIP1/STAT3/GNAI2/SLC1A3 14 GO:0009394 2'-deoxyribonucleotide metabolic process 2/502 40/18722 0.291263845662428 0.458294744909657 SAMHD1/TYMP 2 GO:0010863 positive regulation of phospholipase C activity 2/502 40/18722 0.291263845662428 0.458294744909657 CD86/C5AR1 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/502 40/18722 0.291263845662428 0.458294744909657 ARRB2/LYN 2 GO:0043001 Golgi to plasma membrane protein transport 2/502 40/18722 0.291263845662428 0.458294744909657 MACF1/GOLGA4 2 GO:0044275 cellular carbohydrate catabolic process 2/502 40/18722 0.291263845662428 0.458294744909657 PYGL/GAA 2 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/502 40/18722 0.291263845662428 0.458294744909657 ATM/DUSP1 2 GO:0055081 anion homeostasis 2/502 40/18722 0.291263845662428 0.458294744909657 TBXAS1/GLS 2 GO:0072210 metanephric nephron development 2/502 40/18722 0.291263845662428 0.458294744909657 EGR1/STAT1 2 GO:0055088 lipid homeostasis 6/502 167/18722 0.29163283936475 0.458719318225547 APOE/NPC2/ABCA1/XBP1/RTN4/USF2 6 GO:0062014 negative regulation of small molecule metabolic process 4/502 102/18722 0.292633933800432 0.45941660550743 APOE/PLEK/NUPR1/STAT3 4 GO:0099177 regulation of trans-synaptic signaling 14/502 440/18722 0.294065054820403 0.45941660550743 MEF2C/CCL2/TYROBP/LGMN/APOE/SRGN/ARRB2/PRNP/JAK2/GLUL/CYFIP1/STAT3/GNAI2/SLC1A3 14 GO:0006403 RNA localization 7/502 201/18722 0.294843249241258 0.45941660550743 ZFP36L1/MX2/ZFP36/ATM/TGFBR2/QKI/RANBP2 7 GO:0003281 ventricular septum development 3/502 71/18722 0.296854590665283 0.45941660550743 RBPJ/TGFBR2/CITED2 3 GO:0050818 regulation of coagulation 3/502 71/18722 0.296854590665283 0.45941660550743 APOE/CD36/SERPING1 3 GO:0001768 establishment of T cell polarity 1/502 13/18722 0.297736918139056 0.45941660550743 GSN 1 GO:0001973 G protein-coupled adenosine receptor signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 GNAI2 1 GO:0002087 regulation of respiratory gaseous exchange by nervous system process 1/502 13/18722 0.297736918139056 0.45941660550743 GLS 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/502 13/18722 0.297736918139056 0.45941660550743 STAT1 1 GO:0005513 detection of calcium ion 1/502 13/18722 0.297736918139056 0.45941660550743 CALM2 1 GO:0006264 mitochondrial DNA replication 1/502 13/18722 0.297736918139056 0.45941660550743 ATG7 1 GO:0006995 cellular response to nitrogen starvation 1/502 13/18722 0.297736918139056 0.45941660550743 ATG7 1 GO:0007183 SMAD protein complex assembly 1/502 13/18722 0.297736918139056 0.45941660550743 TGFB1 1 GO:0009143 nucleoside triphosphate catabolic process 1/502 13/18722 0.297736918139056 0.45941660550743 SAMHD1 1 GO:0009650 UV protection 1/502 13/18722 0.297736918139056 0.45941660550743 GPX1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/502 13/18722 0.297736918139056 0.45941660550743 ABCA1 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/502 13/18722 0.297736918139056 0.45941660550743 BNIP3L 1 GO:0014745 negative regulation of muscle adaptation 1/502 13/18722 0.297736918139056 0.45941660550743 KLF4 1 GO:0016246 RNA interference 1/502 13/18722 0.297736918139056 0.45941660550743 ADAR 1 GO:0016322 neuron remodeling 1/502 13/18722 0.297736918139056 0.45941660550743 C1QA 1 GO:0030836 positive regulation of actin filament depolymerization 1/502 13/18722 0.297736918139056 0.45941660550743 PLEK 1 GO:0031053 primary miRNA processing 1/502 13/18722 0.297736918139056 0.45941660550743 STAT3 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/502 13/18722 0.297736918139056 0.45941660550743 CD74 1 GO:0032494 response to peptidoglycan 1/502 13/18722 0.297736918139056 0.45941660550743 C5AR1 1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 LYN 1 GO:0035588 G protein-coupled purinergic receptor signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 GNAI2 1 GO:0036462 TRAIL-activated apoptotic signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 SPI1 1 GO:0042308 negative regulation of protein import into nucleus 1/502 13/18722 0.297736918139056 0.45941660550743 CD36 1 GO:0042362 fat-soluble vitamin biosynthetic process 1/502 13/18722 0.297736918139056 0.45941660550743 PLTP 1 GO:0043201 response to leucine 1/502 13/18722 0.297736918139056 0.45941660550743 SESN1 1 GO:0043562 cellular response to nitrogen levels 1/502 13/18722 0.297736918139056 0.45941660550743 ATG7 1 GO:0044090 positive regulation of vacuole organization 1/502 13/18722 0.297736918139056 0.45941660550743 GRN 1 GO:0044794 positive regulation by host of viral process 1/502 13/18722 0.297736918139056 0.45941660550743 APOE 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/502 13/18722 0.297736918139056 0.45941660550743 NCF1 1 GO:0048012 hepatocyte growth factor receptor signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 NRP1 1 GO:0048070 regulation of developmental pigmentation 1/502 13/18722 0.297736918139056 0.45941660550743 ZEB2 1 GO:0048820 hair follicle maturation 1/502 13/18722 0.297736918139056 0.45941660550743 RBPJ 1 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 1/502 13/18722 0.297736918139056 0.45941660550743 CALM2 1 GO:0051451 myoblast migration 1/502 13/18722 0.297736918139056 0.45941660550743 PLEKHO1 1 GO:0070234 positive regulation of T cell apoptotic process 1/502 13/18722 0.297736918139056 0.45941660550743 LGALS9 1 GO:0070254 mucus secretion 1/502 13/18722 0.297736918139056 0.45941660550743 CYBA 1 GO:0071696 ectodermal placode development 1/502 13/18722 0.297736918139056 0.45941660550743 NRP1 1 GO:0072310 glomerular epithelial cell development 1/502 13/18722 0.297736918139056 0.45941660550743 IQGAP1 1 GO:0072578 neurotransmitter-gated ion channel clustering 1/502 13/18722 0.297736918139056 0.45941660550743 APOE 1 GO:0072672 neutrophil extravasation 1/502 13/18722 0.297736918139056 0.45941660550743 PECAM1 1 GO:0090158 endoplasmic reticulum membrane organization 1/502 13/18722 0.297736918139056 0.45941660550743 RTN4 1 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/502 13/18722 0.297736918139056 0.45941660550743 GNAI2 1 GO:0110096 cellular response to aldehyde 1/502 13/18722 0.297736918139056 0.45941660550743 ALDH1A1 1 GO:0120305 regulation of pigmentation 1/502 13/18722 0.297736918139056 0.45941660550743 ZEB2 1 GO:1900121 negative regulation of receptor binding 1/502 13/18722 0.297736918139056 0.45941660550743 B2M 1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1/502 13/18722 0.297736918139056 0.45941660550743 TMSB4X 1 GO:1904590 negative regulation of protein import 1/502 13/18722 0.297736918139056 0.45941660550743 CD36 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/502 13/18722 0.297736918139056 0.45941660550743 VPS13C 1 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/502 13/18722 0.297736918139056 0.45941660550743 KLF4 1 GO:1905203 regulation of connective tissue replacement 1/502 13/18722 0.297736918139056 0.45941660550743 RUNX1 1 GO:1905269 positive regulation of chromatin organization 1/502 13/18722 0.297736918139056 0.45941660550743 ATF7IP 1 GO:1905907 negative regulation of amyloid fibril formation 1/502 13/18722 0.297736918139056 0.45941660550743 APOE 1 GO:0009135 purine nucleoside diphosphate metabolic process 4/502 103/18722 0.298668265951062 0.459780165820171 IGF1/NUPR1/STAT3/HIF1A 4 GO:0009179 purine ribonucleoside diphosphate metabolic process 4/502 103/18722 0.298668265951062 0.459780165820171 IGF1/NUPR1/STAT3/HIF1A 4 GO:0014013 regulation of gliogenesis 4/502 103/18722 0.298668265951062 0.459780165820171 TNFRSF1B/LYN/TSPO/TGFB1 4 GO:0019233 sensory perception of pain 4/502 103/18722 0.298668265951062 0.459780165820171 CCL2/SCN9A/CCL3/ARRB2 4 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 4/502 103/18722 0.298668265951062 0.459780165820171 PTPRC/IL10RA/PARP14/JAK2 4 GO:0050773 regulation of dendrite development 4/502 103/18722 0.298668265951062 0.459780165820171 PREX1/IQGAP1/ACTR2/CYFIP1 4 GO:1905037 autophagosome organization 4/502 103/18722 0.298668265951062 0.459780165820171 VMP1/ATG7/NUPR1/STX12 4 GO:0001655 urogenital system development 11/502 338/18722 0.29889262561981 0.45997248373827 MEF2C/PLXND1/MTSS1/PSAP/PECAM1/NRP1/EGR1/IQGAP1/AP1B1/STAT1/FEM1B 11 GO:0000075 cell cycle checkpoint signaling 6/502 169/18722 0.300951137615251 0.462577551624997 ATM/DUSP1/NABP1/TAOK3/FEM1B/TAOK1 6 GO:0009152 purine ribonucleotide biosynthetic process 6/502 169/18722 0.300951137615251 0.462577551624997 TMSB4X/PDK4/PPT1/TGFB1/STAT3/ADCY7 6 GO:0001953 negative regulation of cell-matrix adhesion 2/502 41/18722 0.301238694837543 0.462577551624997 LRP1/PIK3R1 2 GO:0048634 regulation of muscle organ development 2/502 41/18722 0.301238694837543 0.462577551624997 MEF2C/TGFB1 2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 2/502 41/18722 0.301238694837543 0.462577551624997 NRP1/PREX1 2 GO:0043401 steroid hormone mediated signaling pathway 5/502 136/18722 0.301285378955062 0.462577551624997 DAB2/JAK2/NCOA4/DDX17/DDX5 5 GO:0072073 kidney epithelium development 5/502 136/18722 0.301285378955062 0.462577551624997 MEF2C/MTSS1/PECAM1/IQGAP1/STAT1 5 GO:0000271 polysaccharide biosynthetic process 3/502 72/18722 0.304211435559949 0.466312985964559 IGF1/CLTC/TGFB1 3 GO:0005977 glycogen metabolic process 3/502 72/18722 0.304211435559949 0.466312985964559 IGF1/PYGL/GAA 3 GO:0033045 regulation of sister chromatid segregation 3/502 72/18722 0.304211435559949 0.466312985964559 RB1/ATM/DUSP1 3 GO:0050709 negative regulation of protein secretion 3/502 72/18722 0.304211435559949 0.466312985964559 APOE/RSAD2/UCP2 3 GO:1901617 organic hydroxy compound biosynthetic process 8/502 237/18722 0.304222350116956 0.466312985964559 PLTP/ZEB2/APOE/PLEK/NR4A2/ASAH1/SPTLC2/ACER3 8 GO:0022600 digestive system process 4/502 104/18722 0.304717386574545 0.466917068663082 CD36/TLR4/TYMP/SGK1 4 GO:0043487 regulation of RNA stability 6/502 170/18722 0.305631260760313 0.468162321946095 TNFRSF1B/ZFP36L1/ZFP36/BTG2/VIM/ZFP36L2 6 GO:0000086 G2/M transition of mitotic cell cycle 5/502 137/18722 0.306529020769418 0.469071534925348 ATM/NABP1/TAOK3/CALM2/TAOK1 5 GO:0034754 cellular hormone metabolic process 5/502 137/18722 0.306529020769418 0.469071534925348 SPP1/ALDH1A1/EGR1/TSPO/DHRS3 5 GO:0060048 cardiac muscle contraction 5/502 137/18722 0.306529020769418 0.469071534925348 ATP1B1/SLC8A1/GAA/CALM2/GSN 5 GO:0150063 visual system development 12/502 375/18722 0.306866334050081 0.469432427683754 C1QA/MAF/SPRED1/ITGAM/NRP1/TGFBR2/VIM/KLF4/STAT3/HIF1A/CITED2/SKIL 12 GO:1901888 regulation of cell junction assembly 7/502 204/18722 0.307612671835243 0.47041858509416 MEF2C/PEAK1/NRP1/IQGAP1/DUSP3/LRP1/MACF1 7 GO:0019692 deoxyribose phosphate metabolic process 2/502 42/18722 0.311189262321836 0.471457889988313 SAMHD1/TYMP 2 GO:0021879 forebrain neuron differentiation 2/502 42/18722 0.311189262321836 0.471457889988313 B2M/NRP1 2 GO:0043507 positive regulation of JUN kinase activity 2/502 42/18722 0.311189262321836 0.471457889988313 SYK/TAOK3 2 GO:0045214 sarcomere organization 2/502 42/18722 0.311189262321836 0.471457889988313 PRKAR1A/AKAP13 2 GO:0045687 positive regulation of glial cell differentiation 2/502 42/18722 0.311189262321836 0.471457889988313 TNFRSF1B/TGFB1 2 GO:0046688 response to copper ion 2/502 42/18722 0.311189262321836 0.471457889988313 ICAM1/PRNP 2 GO:0055090 acylglycerol homeostasis 2/502 42/18722 0.311189262321836 0.471457889988313 APOE/XBP1 2 GO:0070328 triglyceride homeostasis 2/502 42/18722 0.311189262321836 0.471457889988313 APOE/XBP1 2 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 2/502 42/18722 0.311189262321836 0.471457889988313 SPRED1/KLF4 2 GO:0090317 negative regulation of intracellular protein transport 2/502 42/18722 0.311189262321836 0.471457889988313 CD36/SP100 2 GO:1900274 regulation of phospholipase C activity 2/502 42/18722 0.311189262321836 0.471457889988313 CD86/C5AR1 2 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/502 42/18722 0.311189262321836 0.471457889988313 ATM/DUSP1 2 GO:1903432 regulation of TORC1 signaling 2/502 42/18722 0.311189262321836 0.471457889988313 ATM/SESN1 2 GO:2001222 regulation of neuron migration 2/502 42/18722 0.311189262321836 0.471457889988313 STAT3/PLXNB2 2 GO:0006073 cellular glucan metabolic process 3/502 73/18722 0.311576012044961 0.471457889988313 IGF1/PYGL/GAA 3 GO:0035924 cellular response to vascular endothelial growth factor stimulus 3/502 73/18722 0.311576012044961 0.471457889988313 NRP1/CD63/NR4A1 3 GO:0044042 glucan metabolic process 3/502 73/18722 0.311576012044961 0.471457889988313 IGF1/PYGL/GAA 3 GO:0051145 smooth muscle cell differentiation 3/502 73/18722 0.311576012044961 0.471457889988313 MEF2C/SOD2/ENG 3 GO:0051865 protein autoubiquitination 3/502 73/18722 0.311576012044961 0.471457889988313 RNF213/DTX3L/RNF13 3 GO:1904427 positive regulation of calcium ion transmembrane transport 3/502 73/18722 0.311576012044961 0.471457889988313 ATP1B1/VMP1/CALM2 3 GO:0001767 establishment of lymphocyte polarity 1/502 14/18722 0.316580045355593 0.471457889988313 GSN 1 GO:0001921 positive regulation of receptor recycling 1/502 14/18722 0.316580045355593 0.471457889988313 EPS15 1 GO:0002091 negative regulation of receptor internalization 1/502 14/18722 0.316580045355593 0.471457889988313 SDCBP 1 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1/502 14/18722 0.316580045355593 0.471457889988313 TLR4 1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 1/502 14/18722 0.316580045355593 0.471457889988313 TGFBR2 1 GO:0006596 polyamine biosynthetic process 1/502 14/18722 0.316580045355593 0.471457889988313 SAT1 1 GO:0006999 nuclear pore organization 1/502 14/18722 0.316580045355593 0.471457889988313 RTN4 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/502 14/18722 0.316580045355593 0.471457889988313 PDGFC 1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 1/502 14/18722 0.316580045355593 0.471457889988313 SNX6 1 GO:0007638 mechanosensory behavior 1/502 14/18722 0.316580045355593 0.471457889988313 SLC1A3 1 GO:0009159 deoxyribonucleoside monophosphate catabolic process 1/502 14/18722 0.316580045355593 0.471457889988313 TYMP 1 GO:0010421 hydrogen peroxide-mediated programmed cell death 1/502 14/18722 0.316580045355593 0.471457889988313 FOXO3 1 GO:0010872 regulation of cholesterol esterification 1/502 14/18722 0.316580045355593 0.471457889988313 APOE 1 GO:0018158 protein oxidation 1/502 14/18722 0.316580045355593 0.471457889988313 GPX1 1 GO:0030007 cellular potassium ion homeostasis 1/502 14/18722 0.316580045355593 0.471457889988313 ATP1B1 1 GO:0031054 pre-miRNA processing 1/502 14/18722 0.316580045355593 0.471457889988313 ADAR 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/502 14/18722 0.316580045355593 0.471457889988313 SYK 1 GO:0033169 histone H3-K9 demethylation 1/502 14/18722 0.316580045355593 0.471457889988313 JMJD1C 1 GO:0033212 iron import into cell 1/502 14/18722 0.316580045355593 0.471457889988313 SLC11A2 1 GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 1/502 14/18722 0.316580045355593 0.471457889988313 GPR34 1 GO:0035630 bone mineralization involved in bone maturation 1/502 14/18722 0.316580045355593 0.471457889988313 IGF1 1 GO:0035641 locomotory exploration behavior 1/502 14/18722 0.316580045355593 0.471457889988313 APOE 1 GO:0035672 oligopeptide transmembrane transport 1/502 14/18722 0.316580045355593 0.471457889988313 SLC15A3 1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1/502 14/18722 0.316580045355593 0.471457889988313 LRP1 1 GO:0035810 positive regulation of urine volume 1/502 14/18722 0.316580045355593 0.471457889988313 GNAI2 1 GO:0035815 positive regulation of renal sodium excretion 1/502 14/18722 0.316580045355593 0.471457889988313 GNAI2 1 GO:0043249 erythrocyte maturation 1/502 14/18722 0.316580045355593 0.471457889988313 KLF2 1 GO:0043306 positive regulation of mast cell degranulation 1/502 14/18722 0.316580045355593 0.471457889988313 SYK 1 GO:0043455 regulation of secondary metabolic process 1/502 14/18722 0.316580045355593 0.471457889988313 ZEB2 1 GO:0043650 dicarboxylic acid biosynthetic process 1/502 14/18722 0.316580045355593 0.471457889988313 GLS 1 GO:0045837 negative regulation of membrane potential 1/502 14/18722 0.316580045355593 0.471457889988313 BNIP3L 1 GO:0046479 glycosphingolipid catabolic process 1/502 14/18722 0.316580045355593 0.471457889988313 HEXA 1 GO:0048021 regulation of melanin biosynthetic process 1/502 14/18722 0.316580045355593 0.471457889988313 ZEB2 1 GO:0048368 lateral mesoderm development 1/502 14/18722 0.316580045355593 0.471457889988313 CITED2 1 GO:0048681 negative regulation of axon regeneration 1/502 14/18722 0.316580045355593 0.471457889988313 SPP1 1 GO:0048875 chemical homeostasis within a tissue 1/502 14/18722 0.316580045355593 0.471457889988313 OAS1 1 GO:0051547 regulation of keratinocyte migration 1/502 14/18722 0.316580045355593 0.471457889988313 ADAM9 1 GO:0060081 membrane hyperpolarization 1/502 14/18722 0.316580045355593 0.471457889988313 SOD2 1 GO:0060576 intestinal epithelial cell development 1/502 14/18722 0.316580045355593 0.471457889988313 HIF1A 1 GO:0060841 venous blood vessel development 1/502 14/18722 0.316580045355593 0.471457889988313 ENG 1 GO:0060911 cardiac cell fate commitment 1/502 14/18722 0.316580045355593 0.471457889988313 RBPJ 1 GO:0070141 response to UV-A 1/502 14/18722 0.316580045355593 0.471457889988313 TIMP1 1 GO:0070307 lens fiber cell development 1/502 14/18722 0.316580045355593 0.471457889988313 VIM 1 GO:0070986 left/right axis specification 1/502 14/18722 0.316580045355593 0.471457889988313 CITED2 1 GO:0071285 cellular response to lithium ion 1/502 14/18722 0.316580045355593 0.471457889988313 ADCY7 1 GO:0071415 cellular response to purine-containing compound 1/502 14/18722 0.316580045355593 0.471457889988313 SLC8A1 1 GO:0071481 cellular response to X-ray 1/502 14/18722 0.316580045355593 0.471457889988313 ATM 1 GO:0072540 T-helper 17 cell lineage commitment 1/502 14/18722 0.316580045355593 0.471457889988313 STAT3 1 GO:0090239 regulation of histone H4 acetylation 1/502 14/18722 0.316580045355593 0.471457889988313 SPI1 1 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 1/502 14/18722 0.316580045355593 0.471457889988313 ATF7IP 1 GO:0098734 macromolecule depalmitoylation 1/502 14/18722 0.316580045355593 0.471457889988313 PPT1 1 GO:0099188 postsynaptic cytoskeleton organization 1/502 14/18722 0.316580045355593 0.471457889988313 ACTB 1 GO:1900037 regulation of cellular response to hypoxia 1/502 14/18722 0.316580045355593 0.471457889988313 TMBIM6 1 GO:1900376 regulation of secondary metabolite biosynthetic process 1/502 14/18722 0.316580045355593 0.471457889988313 ZEB2 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/502 14/18722 0.316580045355593 0.471457889988313 EGR1 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/502 14/18722 0.316580045355593 0.471457889988313 N4BP2L2 1 GO:1904294 positive regulation of ERAD pathway 1/502 14/18722 0.316580045355593 0.471457889988313 HERPUD1 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/502 14/18722 0.316580045355593 0.471457889988313 VPS13C 1 GO:2001140 positive regulation of phospholipid transport 1/502 14/18722 0.316580045355593 0.471457889988313 APOE 1 GO:2001256 regulation of store-operated calcium entry 1/502 14/18722 0.316580045355593 0.471457889988313 CD84 1 GO:0006906 vesicle fusion 4/502 106/18722 0.316853130128333 0.471457889988313 STX7/SAMD9/STX12/RAB8B 4 GO:0009185 ribonucleoside diphosphate metabolic process 4/502 106/18722 0.316853130128333 0.471457889988313 IGF1/NUPR1/STAT3/HIF1A 4 GO:0090263 positive regulation of canonical Wnt signaling pathway 4/502 106/18722 0.316853130128333 0.471457889988313 ZEB2/RBPJ/TGFB1/ATP6AP2 4 GO:2000278 regulation of DNA biosynthetic process 4/502 106/18722 0.316853130128333 0.471457889988313 ARRB2/ATM/DUSP1/KLF4 4 GO:0009201 ribonucleoside triphosphate biosynthetic process 3/502 74/18722 0.318945433064262 0.473809111546332 TMSB4X/TGFB1/STAT3 3 GO:0010822 positive regulation of mitochondrion organization 3/502 74/18722 0.318945433064262 0.473809111546332 PYCARD/HIF1A/CHCHD10 3 GO:0030968 endoplasmic reticulum unfolded protein response 3/502 74/18722 0.318945433064262 0.473809111546332 XBP1/PIK3R1/HERPUD1 3 GO:0046470 phosphatidylcholine metabolic process 3/502 74/18722 0.318945433064262 0.473809111546332 ENPP2/PLA2G15/CEPT1 3 GO:0051881 regulation of mitochondrial membrane potential 3/502 74/18722 0.318945433064262 0.473809111546332 UCP2/TSPO/BNIP3L 3 GO:0006458 'de novo' protein folding 2/502 43/18722 0.321109687595126 0.475497251861412 CD74/HSPA1A 2 GO:0032365 intracellular lipid transport 2/502 43/18722 0.321109687595126 0.475497251861412 NPC2/ABCA1 2 GO:0033046 negative regulation of sister chromatid segregation 2/502 43/18722 0.321109687595126 0.475497251861412 ATM/DUSP1 2 GO:0033048 negative regulation of mitotic sister chromatid segregation 2/502 43/18722 0.321109687595126 0.475497251861412 ATM/DUSP1 2 GO:0045776 negative regulation of blood pressure 2/502 43/18722 0.321109687595126 0.475497251861412 SOD2/PRCP 2 GO:0060443 mammary gland morphogenesis 2/502 43/18722 0.321109687595126 0.475497251861412 CSF1R/TGFBR2 2 GO:0061383 trabecula morphogenesis 2/502 43/18722 0.321109687595126 0.475497251861412 RBPJ/ENG 2 GO:0120178 steroid hormone biosynthetic process 2/502 43/18722 0.321109687595126 0.475497251861412 EGR1/TSPO 2 GO:2000816 negative regulation of mitotic sister chromatid separation 2/502 43/18722 0.321109687595126 0.475497251861412 ATM/DUSP1 2 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/502 43/18722 0.321109687595126 0.475497251861412 HSPA1A/MCL1 2 GO:0046165 alcohol biosynthetic process 5/502 140/18722 0.322335029345022 0.477158990640022 APOE/PLEK/ASAH1/SPTLC2/ACER3 5 GO:0010927 cellular component assembly involved in morphogenesis 4/502 107/18722 0.322936378615057 0.477590692926232 PMP22/MEF2A/PRKAR1A/AKAP13 4 GO:0051341 regulation of oxidoreductase activity 4/502 107/18722 0.322936378615057 0.477590692926232 APOE/CYBA/GNAI2/HIF1A 4 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 4/502 107/18722 0.322936378615057 0.477590692926232 DAB2/LAPTM5/HSPA1A/HERPUD1 4 GO:0048880 sensory system development 12/502 381/18722 0.325787076459731 0.481652609684472 C1QA/MAF/SPRED1/ITGAM/NRP1/TGFBR2/VIM/KLF4/STAT3/HIF1A/CITED2/SKIL 12 GO:0043627 response to estrogen 3/502 75/18722 0.32631688489844 0.482281760236481 TGFBR2/NCOA4/CITED2 3 GO:0032355 response to estradiol 5/502 141/18722 0.327625014751644 0.48310687710706 TXNIP/DUSP1/NRIP1/TGFB1/STAT3 5 GO:0098659 inorganic cation import across plasma membrane 4/502 108/18722 0.329027668090685 0.48310687710706 SLC9A9/ATP1B1/PRNP/SLC8A1 4 GO:0099587 inorganic ion import across plasma membrane 4/502 108/18722 0.329027668090685 0.48310687710706 SLC9A9/ATP1B1/PRNP/SLC8A1 4 GO:0022900 electron transport chain 6/502 175/18722 0.329209386887902 0.48310687710706 CYBB/CYBA/NCF2/NCF1/DHRS3/ME2 6 GO:0002792 negative regulation of peptide secretion 2/502 44/18722 0.33099444062164 0.48310687710706 CD74/UCP2 2 GO:0006775 fat-soluble vitamin metabolic process 2/502 44/18722 0.33099444062164 0.48310687710706 PLTP/LGMN 2 GO:0009262 deoxyribonucleotide metabolic process 2/502 44/18722 0.33099444062164 0.48310687710706 SAMHD1/TYMP 2 GO:0044058 regulation of digestive system process 2/502 44/18722 0.33099444062164 0.48310687710706 TYMP/SGK1 2 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 2/502 44/18722 0.33099444062164 0.48310687710706 IL10RA/JAK2 2 GO:0050999 regulation of nitric-oxide synthase activity 2/502 44/18722 0.33099444062164 0.48310687710706 APOE/HIF1A 2 GO:0051150 regulation of smooth muscle cell differentiation 2/502 44/18722 0.33099444062164 0.48310687710706 SOD2/ENG 2 GO:0045787 positive regulation of cell cycle 10/502 313/18722 0.331340103292519 0.48310687710706 IGF1/CD28/AIF1/LGMN/RB1/PLSCR1/NUPR1/DUSP3/CITED2/KMT2E 10 GO:0046467 membrane lipid biosynthetic process 5/502 142/18722 0.332923825816067 0.48310687710706 ASAH1/SGMS1/ST8SIA4/SPTLC2/ACER3 5 GO:0046546 development of primary male sexual characteristics 5/502 142/18722 0.332923825816067 0.48310687710706 ICAM1/LHFPL2/NUPR1/NCOA4/CITED2 5 GO:0021536 diencephalon development 3/502 76/18722 0.333687627330473 0.48310687710706 RBPJ/NR4A2/NRP1 3 GO:0002836 positive regulation of response to tumor cell 1/502 15/18722 0.334918553867005 0.48310687710706 HLA-DRB1 1 GO:0002839 positive regulation of immune response to tumor cell 1/502 15/18722 0.334918553867005 0.48310687710706 HLA-DRB1 1 GO:0006089 lactate metabolic process 1/502 15/18722 0.334918553867005 0.48310687710706 HIF1A 1 GO:0006825 copper ion transport 1/502 15/18722 0.334918553867005 0.48310687710706 SLC11A2 1 GO:0006878 cellular copper ion homeostasis 1/502 15/18722 0.334918553867005 0.48310687710706 PRNP 1 GO:0010713 negative regulation of collagen metabolic process 1/502 15/18722 0.334918553867005 0.48310687710706 CST3 1 GO:0010820 positive regulation of T cell chemotaxis 1/502 15/18722 0.334918553867005 0.48310687710706 ADAM10 1 GO:0010832 negative regulation of myotube differentiation 1/502 15/18722 0.334918553867005 0.48310687710706 XBP1 1 GO:0010940 positive regulation of necrotic cell death 1/502 15/18722 0.334918553867005 0.48310687710706 TSPO 1 GO:0016446 somatic hypermutation of immunoglobulin genes 1/502 15/18722 0.334918553867005 0.48310687710706 SAMHD1 1 GO:0018410 C-terminal protein amino acid modification 1/502 15/18722 0.334918553867005 0.48310687710706 ATG7 1 GO:0019511 peptidyl-proline hydroxylation 1/502 15/18722 0.334918553867005 0.48310687710706 P4HA1 1 GO:0021542 dentate gyrus development 1/502 15/18722 0.334918553867005 0.48310687710706 BTG2 1 GO:0023035 CD40 signaling pathway 1/502 15/18722 0.334918553867005 0.48310687710706 CD86 1 GO:0030252 growth hormone secretion 1/502 15/18722 0.334918553867005 0.48310687710706 ITSN1 1 GO:0031958 corticosteroid receptor signaling pathway 1/502 15/18722 0.334918553867005 0.48310687710706 JAK2 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/502 15/18722 0.334918553867005 0.48310687710706 SYK 1 GO:0034384 high-density lipoprotein particle clearance 1/502 15/18722 0.334918553867005 0.48310687710706 APOE 1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 1/502 15/18722 0.334918553867005 0.48310687710706 CITED2 1 GO:0042976 activation of Janus kinase activity 1/502 15/18722 0.334918553867005 0.48310687710706 JAK2 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/502 15/18722 0.334918553867005 0.48310687710706 TMSB4X 1 GO:0043252 sodium-independent organic anion transport 1/502 15/18722 0.334918553867005 0.48310687710706 SLCO2B1 1 GO:0045064 T-helper 2 cell differentiation 1/502 15/18722 0.334918553867005 0.48310687710706 CD86 1 GO:0045176 apical protein localization 1/502 15/18722 0.334918553867005 0.48310687710706 ACTB 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/502 15/18722 0.334918553867005 0.48310687710706 IGF1 1 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 1/502 15/18722 0.334918553867005 0.48310687710706 RB1 1 GO:0046500 S-adenosylmethionine metabolic process 1/502 15/18722 0.334918553867005 0.48310687710706 MAT2A 1 GO:0048569 post-embryonic animal organ development 1/502 15/18722 0.334918553867005 0.48310687710706 KLF4 1 GO:0051284 positive regulation of sequestering of calcium ion 1/502 15/18722 0.334918553867005 0.48310687710706 CALM2 1 GO:0051608 histamine transport 1/502 15/18722 0.334918553867005 0.48310687710706 LYN 1 GO:0051775 response to redox state 1/502 15/18722 0.334918553867005 0.48310687710706 ARHGDIB 1 GO:0051938 L-glutamate import 1/502 15/18722 0.334918553867005 0.48310687710706 SLC1A3 1 GO:0055091 phospholipid homeostasis 1/502 15/18722 0.334918553867005 0.48310687710706 ABCA1 1 GO:0060253 negative regulation of glial cell proliferation 1/502 15/18722 0.334918553867005 0.48310687710706 TSPO 1 GO:0060766 negative regulation of androgen receptor signaling pathway 1/502 15/18722 0.334918553867005 0.48310687710706 DAB2 1 GO:0070207 protein homotrimerization 1/502 15/18722 0.334918553867005 0.48310687710706 ALOX5AP 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/502 15/18722 0.334918553867005 0.48310687710706 CD81 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/502 15/18722 0.334918553867005 0.48310687710706 PRNP 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/502 15/18722 0.334918553867005 0.48310687710706 IGF1 1 GO:0071380 cellular response to prostaglandin E stimulus 1/502 15/18722 0.334918553867005 0.48310687710706 PTGER4 1 GO:0072075 metanephric mesenchyme development 1/502 15/18722 0.334918553867005 0.48310687710706 STAT1 1 GO:0072224 metanephric glomerulus development 1/502 15/18722 0.334918553867005 0.48310687710706 EGR1 1 GO:0080154 regulation of fertilization 1/502 15/18722 0.334918553867005 0.48310687710706 LHFPL2 1 GO:0097468 programmed cell death in response to reactive oxygen species 1/502 15/18722 0.334918553867005 0.48310687710706 FOXO3 1 GO:0098712 L-glutamate import across plasma membrane 1/502 15/18722 0.334918553867005 0.48310687710706 SLC1A3 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/502 15/18722 0.334918553867005 0.48310687710706 CYFIP1 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/502 15/18722 0.334918553867005 0.48310687710706 PRNP 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/502 15/18722 0.334918553867005 0.48310687710706 IGF1 1 GO:0110156 methylguanosine-cap decapping 1/502 15/18722 0.334918553867005 0.48310687710706 ZFP36 1 GO:0150011 regulation of neuron projection arborization 1/502 15/18722 0.334918553867005 0.48310687710706 MACF1 1 GO:1901660 calcium ion export 1/502 15/18722 0.334918553867005 0.48310687710706 CALM2 1 GO:1901741 positive regulation of myoblast fusion 1/502 15/18722 0.334918553867005 0.48310687710706 CD53 1 GO:1901970 positive regulation of mitotic sister chromatid separation 1/502 15/18722 0.334918553867005 0.48310687710706 RB1 1 GO:1902902 negative regulation of autophagosome assembly 1/502 15/18722 0.334918553867005 0.48310687710706 NUPR1 1 GO:1903543 positive regulation of exosomal secretion 1/502 15/18722 0.334918553867005 0.48310687710706 SDCBP 1 GO:1903729 regulation of plasma membrane organization 1/502 15/18722 0.334918553867005 0.48310687710706 GSN 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/502 15/18722 0.334918553867005 0.48310687710706 DAB2 1 GO:2000104 negative regulation of DNA-dependent DNA replication 1/502 15/18722 0.334918553867005 0.48310687710706 ATG7 1 GO:2000345 regulation of hepatocyte proliferation 1/502 15/18722 0.334918553867005 0.48310687710706 XBP1 1 GO:2000402 negative regulation of lymphocyte migration 1/502 15/18722 0.334918553867005 0.48310687710706 CCL2 1 GO:2001138 regulation of phospholipid transport 1/502 15/18722 0.334918553867005 0.48310687710706 APOE 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/502 15/18722 0.334918553867005 0.48310687710706 CD74 1 GO:0006821 chloride transport 4/502 109/18722 0.335125371516765 0.48310687710706 TTYH3/PRNP/TSPO/SLC1A3 4 GO:0043266 regulation of potassium ion transport 4/502 109/18722 0.335125371516765 0.48310687710706 ATP1B1/PRNP/CD63/CAB39 4 GO:0006091 generation of precursor metabolites and energy 15/502 490/18722 0.336620270126866 0.485110707042643 CYBB/IGF1/CYBA/PYGL/NCF2/NCF1/NUPR1/DHRS3/STAT3/HIF1A/GAA/CHCHD10/IFNAR1/ME2/GNPDA1 15 GO:0062013 positive regulation of small molecule metabolic process 5/502 143/18722 0.338230378314418 0.487279268166459 IGF1/TMSB4X/CD74/STAT3/HIF1A 5 GO:0003009 skeletal muscle contraction 2/502 45/18722 0.340838308401296 0.488912426662705 NR4A1/GAA 2 GO:0030850 prostate gland development 2/502 45/18722 0.340838308401296 0.488912426662705 PSAP/FEM1B 2 GO:0035305 negative regulation of dephosphorylation 2/502 45/18722 0.340838308401296 0.488912426662705 NCKAP1L/GNAI2 2 GO:0035384 thioester biosynthetic process 2/502 45/18722 0.340838308401296 0.488912426662705 PDK4/PPT1 2 GO:0044088 regulation of vacuole organization 2/502 45/18722 0.340838308401296 0.488912426662705 GRN/NUPR1 2 GO:0046189 phenol-containing compound biosynthetic process 2/502 45/18722 0.340838308401296 0.488912426662705 ZEB2/NR4A2 2 GO:0048538 thymus development 2/502 45/18722 0.340838308401296 0.488912426662705 MAFB/CITED2 2 GO:0048599 oocyte development 2/502 45/18722 0.340838308401296 0.488912426662705 IGF1/FOXO3 2 GO:0051180 vitamin transport 2/502 45/18722 0.340838308401296 0.488912426662705 FOLR2/SLC2A3 2 GO:0051985 negative regulation of chromosome segregation 2/502 45/18722 0.340838308401296 0.488912426662705 ATM/DUSP1 2 GO:0071616 acyl-CoA biosynthetic process 2/502 45/18722 0.340838308401296 0.488912426662705 PDK4/PPT1 2 GO:0085029 extracellular matrix assembly 2/502 45/18722 0.340838308401296 0.488912426662705 GAS6/TGFB1 2 GO:1905819 negative regulation of chromosome separation 2/502 45/18722 0.340838308401296 0.488912426662705 ATM/DUSP1 2 GO:0007492 endoderm development 3/502 77/18722 0.341054993696617 0.488912426662705 ITGB2/ZFP36L1/DUSP1 3 GO:0048644 muscle organ morphogenesis 3/502 77/18722 0.341054993696617 0.488912426662705 RBPJ/ENG/TGFB1 3 GO:0055117 regulation of cardiac muscle contraction 3/502 77/18722 0.341054993696617 0.488912426662705 ATP1B1/SLC8A1/CALM2 3 GO:0090174 organelle membrane fusion 4/502 110/18722 0.34122788702095 0.489008737719614 STX7/SAMD9/STX12/RAB8B 4 GO:0006470 protein dephosphorylation 9/502 281/18722 0.34137534876247 0.489068554777078 NCKAP1L/PTPRC/JAK2/DUSP1/TGFB1/PTPN6/GNAI2/DUSP3/CALM2 9 GO:0035725 sodium ion transmembrane transport 6/502 178/18722 0.343469631756752 0.491916568577937 SCN9A/SLC9A9/ATP1B1/SLC8A1/FXYD5/SLC4A7 6 GO:0015718 monocarboxylic acid transport 4/502 111/18722 0.347333638431812 0.49466359420543 SLCO2B1/CD36/SYK/EMB 4 GO:0006941 striated muscle contraction 6/502 179/18722 0.348237235595188 0.49466359420543 ATP1B1/SLC8A1/NR4A1/GAA/CALM2/GSN 6 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 3/502 78/18722 0.348416390829836 0.49466359420543 LAPTM5/JAK2/PYCARD 3 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 3/502 78/18722 0.348416390829836 0.49466359420543 PSAP/RGS1/GNAI2 3 GO:0061045 negative regulation of wound healing 3/502 78/18722 0.348416390829836 0.49466359420543 APOE/SERPING1/ALOX5 3 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 3/502 78/18722 0.348416390829836 0.49466359420543 SPRED1/NRP1/KLF4 3 GO:0044262 cellular carbohydrate metabolic process 9/502 283/18722 0.348918310053118 0.49466359420543 IGF1/IGFBP4/PLEK/PDK4/PYGL/NUPR1/STAT3/GAA/RANBP2 9 GO:0031648 protein destabilization 2/502 46/18722 0.350636382002257 0.49466359420543 PRNP/GSN 2 GO:0032924 activin receptor signaling pathway 2/502 46/18722 0.350636382002257 0.49466359420543 TGFBR2/CITED2 2 GO:0033047 regulation of mitotic sister chromatid segregation 2/502 46/18722 0.350636382002257 0.49466359420543 ATM/DUSP1 2 GO:0034198 cellular response to amino acid starvation 2/502 46/18722 0.350636382002257 0.49466359420543 UCP2/SESN1 2 GO:0043616 keratinocyte proliferation 2/502 46/18722 0.350636382002257 0.49466359420543 ZFP36L1/ZFP36 2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 2/502 46/18722 0.350636382002257 0.49466359420543 AIF1/KMT2E 2 GO:0001574 ganglioside biosynthetic process 1/502 16/18722 0.352765931103267 0.49466359420543 ST8SIA4 1 GO:0002693 positive regulation of cellular extravasation 1/502 16/18722 0.352765931103267 0.49466359420543 ICAM1 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/502 16/18722 0.352765931103267 0.49466359420543 CYBA 1 GO:0006004 fucose metabolic process 1/502 16/18722 0.352765931103267 0.49466359420543 FUCA1 1 GO:0006206 pyrimidine nucleobase metabolic process 1/502 16/18722 0.352765931103267 0.49466359420543 TYMP 1 GO:0006750 glutathione biosynthetic process 1/502 16/18722 0.352765931103267 0.49466359420543 MGST2 1 GO:0006828 manganese ion transport 1/502 16/18722 0.352765931103267 0.49466359420543 SLC11A2 1 GO:0006857 oligopeptide transport 1/502 16/18722 0.352765931103267 0.49466359420543 SLC15A3 1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1/502 16/18722 0.352765931103267 0.49466359420543 SP100 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/502 16/18722 0.352765931103267 0.49466359420543 XIST 1 GO:0010819 regulation of T cell chemotaxis 1/502 16/18722 0.352765931103267 0.49466359420543 ADAM10 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/502 16/18722 0.352765931103267 0.49466359420543 PLEK 1 GO:0014819 regulation of skeletal muscle contraction 1/502 16/18722 0.352765931103267 0.49466359420543 NR4A1 1 GO:0021783 preganglionic parasympathetic fiber development 1/502 16/18722 0.352765931103267 0.49466359420543 NRP1 1 GO:0030033 microvillus assembly 1/502 16/18722 0.352765931103267 0.49466359420543 FXYD5 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 1/502 16/18722 0.352765931103267 0.49466359420543 HIF1A 1 GO:0034116 positive regulation of heterotypic cell-cell adhesion 1/502 16/18722 0.352765931103267 0.49466359420543 CD44 1 GO:0034374 low-density lipoprotein particle remodeling 1/502 16/18722 0.352765931103267 0.49466359420543 APOE 1 GO:0035067 negative regulation of histone acetylation 1/502 16/18722 0.352765931103267 0.49466359420543 SPI1 1 GO:0035970 peptidyl-threonine dephosphorylation 1/502 16/18722 0.352765931103267 0.49466359420543 DUSP1 1 GO:0042407 cristae formation 1/502 16/18722 0.352765931103267 0.49466359420543 CHCHD10 1 GO:0043923 positive regulation by host of viral transcription 1/502 16/18722 0.352765931103267 0.49466359420543 JUN 1 GO:0044065 regulation of respiratory system process 1/502 16/18722 0.352765931103267 0.49466359420543 GLS 1 GO:0044804 autophagy of nucleus 1/502 16/18722 0.352765931103267 0.49466359420543 ATG7 1 GO:0044849 estrous cycle 1/502 16/18722 0.352765931103267 0.49466359420543 EGR1 1 GO:0048311 mitochondrion distribution 1/502 16/18722 0.352765931103267 0.49466359420543 MEF2A 1 GO:0050862 positive regulation of T cell receptor signaling pathway 1/502 16/18722 0.352765931103267 0.49466359420543 CD81 1 GO:0050884 neuromuscular process controlling posture 1/502 16/18722 0.352765931103267 0.49466359420543 GAA 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/502 16/18722 0.352765931103267 0.49466359420543 ARRB2 1 GO:0051969 regulation of transmission of nerve impulse 1/502 16/18722 0.352765931103267 0.49466359420543 TYMP 1 GO:0061548 ganglion development 1/502 16/18722 0.352765931103267 0.49466359420543 NRP1 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/502 16/18722 0.352765931103267 0.49466359420543 LGALS9 1 GO:0070242 thymocyte apoptotic process 1/502 16/18722 0.352765931103267 0.49466359420543 HIF1A 1 GO:0070571 negative regulation of neuron projection regeneration 1/502 16/18722 0.352765931103267 0.49466359420543 SPP1 1 GO:0071391 cellular response to estrogen stimulus 1/502 16/18722 0.352765931103267 0.49466359420543 NCOA4 1 GO:0072109 glomerular mesangium development 1/502 16/18722 0.352765931103267 0.49466359420543 EGR1 1 GO:0072283 metanephric renal vesicle morphogenesis 1/502 16/18722 0.352765931103267 0.49466359420543 STAT1 1 GO:0090231 regulation of spindle checkpoint 1/502 16/18722 0.352765931103267 0.49466359420543 DUSP1 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/502 16/18722 0.352765931103267 0.49466359420543 DUSP1 1 GO:0090336 positive regulation of brown fat cell differentiation 1/502 16/18722 0.352765931103267 0.49466359420543 METRNL 1 GO:0098884 postsynaptic neurotransmitter receptor internalization 1/502 16/18722 0.352765931103267 0.49466359420543 EPS15 1 GO:0099633 protein localization to postsynaptic specialization membrane 1/502 16/18722 0.352765931103267 0.49466359420543 ADAM10 1 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 1/502 16/18722 0.352765931103267 0.49466359420543 ADAM10 1 GO:0140239 postsynaptic endocytosis 1/502 16/18722 0.352765931103267 0.49466359420543 EPS15 1 GO:1901201 regulation of extracellular matrix assembly 1/502 16/18722 0.352765931103267 0.49466359420543 TGFB1 1 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/502 16/18722 0.352765931103267 0.49466359420543 RB1 1 GO:1902570 protein localization to nucleolus 1/502 16/18722 0.352765931103267 0.49466359420543 GLUL 1 GO:1903504 regulation of mitotic spindle checkpoint 1/502 16/18722 0.352765931103267 0.49466359420543 DUSP1 1 GO:1904683 regulation of metalloendopeptidase activity 1/502 16/18722 0.352765931103267 0.49466359420543 STAT3 1 GO:1904948 midbrain dopaminergic neuron differentiation 1/502 16/18722 0.352765931103267 0.49466359420543 NR4A2 1 GO:1905906 regulation of amyloid fibril formation 1/502 16/18722 0.352765931103267 0.49466359420543 APOE 1 GO:2000001 regulation of DNA damage checkpoint 1/502 16/18722 0.352765931103267 0.49466359420543 FEM1B 1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1/502 16/18722 0.352765931103267 0.49466359420543 DAB2 1 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 1/502 16/18722 0.352765931103267 0.49466359420543 ATP1B1 1 GO:2000765 regulation of cytoplasmic translation 1/502 16/18722 0.352765931103267 0.49466359420543 CPEB4 1 GO:2001212 regulation of vasculogenesis 1/502 16/18722 0.352765931103267 0.49466359420543 RIN2 1 GO:0001676 long-chain fatty acid metabolic process 4/502 112/18722 0.353441075769174 0.495460126214605 TBXAS1/ALOX5/GPX1/QKI 4 GO:0000245 spliceosomal complex assembly 3/502 79/18722 0.355769298902854 0.498270898190919 CELF2/SETX/SCAF11 3 GO:0001895 retina homeostasis 3/502 79/18722 0.355769298902854 0.498270898190919 B2M/ACTB/DRAM2 3 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 3/502 79/18722 0.355769298902854 0.498270898190919 NRP1/PREX1/ACTR2 3 GO:0006302 double-strand break repair 8/502 251/18722 0.360289250045845 0.503514523653131 SAMHD1/PARP9/ATM/ACTR2/DTX3L/WAS/NABP1/SETX 8 GO:0032008 positive regulation of TOR signaling 2/502 47/18722 0.360384044058693 0.503514523653131 GAS6/NCKAP1L 2 GO:0035315 hair cell differentiation 2/502 47/18722 0.360384044058693 0.503514523653131 RBPJ/SLC4A7 2 GO:0043114 regulation of vascular permeability 2/502 47/18722 0.360384044058693 0.503514523653131 APOE/TGFB1 2 GO:0045747 positive regulation of Notch signaling pathway 2/502 47/18722 0.360384044058693 0.503514523653131 BMP2K/STAT3 2 GO:0048512 circadian behavior 2/502 47/18722 0.360384044058693 0.503514523653131 EGR1/ZFHX3 2 GO:0051489 regulation of filopodium assembly 2/502 47/18722 0.360384044058693 0.503514523653131 NRP1/PIK3R1 2 GO:0061001 regulation of dendritic spine morphogenesis 2/502 47/18722 0.360384044058693 0.503514523653131 ACTR2/ADAM10 2 GO:0009260 ribonucleotide biosynthetic process 6/502 182/18722 0.362571853626062 0.506418295553794 TMSB4X/PDK4/PPT1/TGFB1/STAT3/ADCY7 6 GO:0007422 peripheral nervous system development 3/502 80/18722 0.363111271177585 0.507018635818747 PMP22/RUNX1/CITED2 3 GO:0044272 sulfur compound biosynthetic process 5/502 148/18722 0.364842086092337 0.509107288516059 PDK4/PPT1/DSE/MGST2/MAT2A 5 GO:0019751 polyol metabolic process 4/502 114/18722 0.365654941900476 0.509107288516059 PLEK/ASAH1/SPTLC2/ACER3 4 GO:0021987 cerebral cortex development 4/502 114/18722 0.365654941900476 0.509107288516059 HIF1A/RTN4/TACC1/LRP1 4 GO:1901800 positive regulation of proteasomal protein catabolic process 4/502 114/18722 0.365654941900476 0.509107288516059 DAB2/HSPA1A/NUPR1/HERPUD1 4 GO:0010569 regulation of double-strand break repair via homologous recombination 2/502 48/18722 0.370076956718211 0.509107288516059 ACTR2/WAS 2 GO:0032527 protein exit from endoplasmic reticulum 2/502 48/18722 0.370076956718211 0.509107288516059 CD81/HERPUD1 2 GO:0045839 negative regulation of mitotic nuclear division 2/502 48/18722 0.370076956718211 0.509107288516059 ATM/DUSP1 2 GO:0001710 mesodermal cell fate commitment 1/502 17/18722 0.370135304704581 0.509107288516059 KLF4 1 GO:0002031 G protein-coupled receptor internalization 1/502 17/18722 0.370135304704581 0.509107288516059 ARRB2 1 GO:0007379 segment specification 1/502 17/18722 0.370135304704581 0.509107288516059 MAFB 1 GO:0007625 grooming behavior 1/502 17/18722 0.370135304704581 0.509107288516059 PPT1 1 GO:0008334 histone mRNA metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 ATM 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 SAMHD1 1 GO:0009200 deoxyribonucleoside triphosphate metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 SAMHD1 1 GO:0010566 regulation of ketone biosynthetic process 1/502 17/18722 0.370135304704581 0.509107288516059 EGR1 1 GO:0015867 ATP transport 1/502 17/18722 0.370135304704581 0.509107288516059 CR1 1 GO:0021924 cell proliferation in external granule layer 1/502 17/18722 0.370135304704581 0.509107288516059 ATF5 1 GO:0021930 cerebellar granule cell precursor proliferation 1/502 17/18722 0.370135304704581 0.509107288516059 ATF5 1 GO:0030002 cellular anion homeostasis 1/502 17/18722 0.370135304704581 0.509107288516059 TBXAS1 1 GO:0030322 stabilization of membrane potential 1/502 17/18722 0.370135304704581 0.509107288516059 CHCHD10 1 GO:0031445 regulation of heterochromatin assembly 1/502 17/18722 0.370135304704581 0.509107288516059 ATF7IP 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/502 17/18722 0.370135304704581 0.509107288516059 ATM 1 GO:0036166 phenotypic switching 1/502 17/18722 0.370135304704581 0.509107288516059 SOD2 1 GO:0042339 keratan sulfate metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 GNS 1 GO:0042448 progesterone metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 EGR1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/502 17/18722 0.370135304704581 0.509107288516059 PARP14 1 GO:0042772 DNA damage response, signal transduction resulting in transcription 1/502 17/18722 0.370135304704581 0.509107288516059 SP100 1 GO:0043649 dicarboxylic acid catabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 GLUL 1 GO:0044539 long-chain fatty acid import into cell 1/502 17/18722 0.370135304704581 0.509107288516059 CD36 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/502 17/18722 0.370135304704581 0.509107288516059 MSN 1 GO:0046827 positive regulation of protein export from nucleus 1/502 17/18722 0.370135304704581 0.509107288516059 GAS6 1 GO:0048532 anatomical structure arrangement 1/502 17/18722 0.370135304704581 0.509107288516059 NRP1 1 GO:0055003 cardiac myofibril assembly 1/502 17/18722 0.370135304704581 0.509107288516059 MEF2A 1 GO:0055064 chloride ion homeostasis 1/502 17/18722 0.370135304704581 0.509107288516059 TBXAS1 1 GO:0055083 monovalent inorganic anion homeostasis 1/502 17/18722 0.370135304704581 0.509107288516059 TBXAS1 1 GO:0060033 anatomical structure regression 1/502 17/18722 0.370135304704581 0.509107288516059 SPI1 1 GO:0060644 mammary gland epithelial cell differentiation 1/502 17/18722 0.370135304704581 0.509107288516059 HIF1A 1 GO:0070593 dendrite self-avoidance 1/502 17/18722 0.370135304704581 0.509107288516059 EMB 1 GO:0070875 positive regulation of glycogen metabolic process 1/502 17/18722 0.370135304704581 0.509107288516059 IGF1 1 GO:0090083 regulation of inclusion body assembly 1/502 17/18722 0.370135304704581 0.509107288516059 HSPA1A 1 GO:0090399 replicative senescence 1/502 17/18722 0.370135304704581 0.509107288516059 ATM 1 GO:0120261 regulation of heterochromatin organization 1/502 17/18722 0.370135304704581 0.509107288516059 ATF7IP 1 GO:0140354 lipid import into cell 1/502 17/18722 0.370135304704581 0.509107288516059 CD36 1 GO:1900034 regulation of cellular response to heat 1/502 17/18722 0.370135304704581 0.509107288516059 ATM 1 GO:1901550 regulation of endothelial cell development 1/502 17/18722 0.370135304704581 0.509107288516059 TNFRSF1A 1 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 1/502 17/18722 0.370135304704581 0.509107288516059 TGFB1 1 GO:1903140 regulation of establishment of endothelial barrier 1/502 17/18722 0.370135304704581 0.509107288516059 TNFRSF1A 1 GO:1903541 regulation of exosomal secretion 1/502 17/18722 0.370135304704581 0.509107288516059 SDCBP 1 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 1/502 17/18722 0.370135304704581 0.509107288516059 STAT1 1 GO:0001523 retinoid metabolic process 3/502 81/18722 0.370439933667327 0.509107288516059 ALDH1A1/DHRS3/LRP1 3 GO:0014032 neural crest cell development 3/502 81/18722 0.370439933667327 0.509107288516059 NRP1/HIF1A/CITED2 3 GO:0021954 central nervous system neuron development 3/502 81/18722 0.370439933667327 0.509107288516059 NR4A2/NRP1/BTG2 3 GO:0044773 mitotic DNA damage checkpoint signaling 3/502 81/18722 0.370439933667327 0.509107288516059 ATM/TAOK3/TAOK1 3 GO:0000077 DNA damage checkpoint signaling 4/502 115/18722 0.371758405507839 0.510767562779704 ATM/TAOK3/FEM1B/TAOK1 4 GO:2001257 regulation of cation channel activity 6/502 184/18722 0.372147220577472 0.511149953204093 MEF2C/CCL2/TMSB4X/CTSS/IFNGR2/CALM2 6 GO:0009165 nucleotide biosynthetic process 8/502 254/18722 0.372469080966875 0.511440180633056 TMSB4X/PARP9/NAMPT/PDK4/PPT1/TGFB1/STAT3/ADCY7 8 GO:0006417 regulation of translation 14/502 468/18722 0.376107652013188 0.516283085523147 CD28/ZFP36L1/MKNK1/ZFP36/EIF4G3/CPEB4/BTG2/VIM/ZFP36L2/QKI/FOXO3/CYFIP1/STAT3/PLXNB2 14 GO:0007369 gastrulation 6/502 185/18722 0.37693835957761 0.517269905489773 ITGB2/DUSP1/TGFBR2/KLF4/ETS2/PRKAR1A 6 GO:0046889 positive regulation of lipid biosynthetic process 3/502 82/18722 0.377752984717858 0.518070354153387 APOE/CD74/CREBL2 3 GO:0006720 isoprenoid metabolic process 4/502 116/18722 0.377857625359604 0.518070354153387 ALDH1A1/NPC2/DHRS3/LRP1 4 GO:0007006 mitochondrial membrane organization 4/502 116/18722 0.377857625359604 0.518070354153387 HSPA1A/STAT3/CHCHD10/BNIP3L 4 GO:0000959 mitochondrial RNA metabolic process 2/502 49/18722 0.379711050023905 0.518919739264575 FOXO3/CHCHD10 2 GO:0006376 mRNA splice site selection 2/502 49/18722 0.379711050023905 0.518919739264575 CELF2/SETX 2 GO:0007622 rhythmic behavior 2/502 49/18722 0.379711050023905 0.518919739264575 EGR1/ZFHX3 2 GO:0009395 phospholipid catabolic process 2/502 49/18722 0.379711050023905 0.518919739264575 ENPP2/PLA2G15 2 GO:0009994 oocyte differentiation 2/502 49/18722 0.379711050023905 0.518919739264575 IGF1/FOXO3 2 GO:0030195 negative regulation of blood coagulation 2/502 49/18722 0.379711050023905 0.518919739264575 APOE/SERPING1 2 GO:0030857 negative regulation of epithelial cell differentiation 2/502 49/18722 0.379711050023905 0.518919739264575 SPRED1/STAT1 2 GO:0038084 vascular endothelial growth factor signaling pathway 2/502 49/18722 0.379711050023905 0.518919739264575 NRP1/CD63 2 GO:0042304 regulation of fatty acid biosynthetic process 2/502 49/18722 0.379711050023905 0.518919739264575 CD74/PDK4 2 GO:0050832 defense response to fungus 2/502 49/18722 0.379711050023905 0.518919739264575 SPI1/CLEC7A 2 GO:1990928 response to amino acid starvation 2/502 49/18722 0.379711050023905 0.518919739264575 UCP2/SESN1 2 GO:1901293 nucleoside phosphate biosynthetic process 8/502 256/18722 0.38060666290553 0.519990083461601 TMSB4X/PARP9/NAMPT/PDK4/PPT1/TGFB1/STAT3/ADCY7 8 GO:0030902 hindbrain development 5/502 151/18722 0.380835095102813 0.520148553275941 AIF1/FCGR2B/MAFB/C5AR1/ATF5 5 GO:0008406 gonad development 7/502 221/18722 0.381500861780974 0.520904069244034 ICAM1/ARRB2/FOXO3/NRIP1/NUPR1/NCOA4/CITED2 7 GO:0005996 monosaccharide metabolic process 8/502 257/18722 0.384679395628695 0.521083965487871 IGF1/IGFBP4/SLC2A3/PDK4/OAS1/FUCA1/GAA/RANBP2 8 GO:0015931 nucleobase-containing compound transport 7/502 222/18722 0.385890886614802 0.521083965487871 CR1/ZFP36L1/MX2/ZFP36/TGFBR2/QKI/RANBP2 7 GO:0008643 carbohydrate transport 5/502 152/18722 0.38616442244711 0.521083965487871 IGF1/SLC2A3/MEF2A/CREBL2/PIK3R1 5 GO:0001822 kidney development 9/502 293/18722 0.386929056191227 0.521083965487871 MEF2C/PLXND1/MTSS1/PECAM1/NRP1/EGR1/IQGAP1/AP1B1/STAT1 9 GO:0002295 T-helper cell lineage commitment 1/502 18/18722 0.387039452100373 0.521083965487871 STAT3 1 GO:0003417 growth plate cartilage development 1/502 18/18722 0.387039452100373 0.521083965487871 TGFBR2 1 GO:0006085 acetyl-CoA biosynthetic process 1/502 18/18722 0.387039452100373 0.521083965487871 PDK4 1 GO:0006595 polyamine metabolic process 1/502 18/18722 0.387039452100373 0.521083965487871 SAT1 1 GO:0006625 protein targeting to peroxisome 1/502 18/18722 0.387039452100373 0.521083965487871 RAB8B 1 GO:0006991 response to sterol depletion 1/502 18/18722 0.387039452100373 0.521083965487871 LYN 1 GO:0007549 dosage compensation 1/502 18/18722 0.387039452100373 0.521083965487871 XIST 1 GO:0009125 nucleoside monophosphate catabolic process 1/502 18/18722 0.387039452100373 0.521083965487871 TYMP 1 GO:0019184 nonribosomal peptide biosynthetic process 1/502 18/18722 0.387039452100373 0.521083965487871 MGST2 1 GO:0019896 axonal transport of mitochondrion 1/502 18/18722 0.387039452100373 0.521083965487871 HIF1A 1 GO:0030206 chondroitin sulfate biosynthetic process 1/502 18/18722 0.387039452100373 0.521083965487871 DSE 1 GO:0030299 intestinal cholesterol absorption 1/502 18/18722 0.387039452100373 0.521083965487871 CD36 1 GO:0031000 response to caffeine 1/502 18/18722 0.387039452100373 0.521083965487871 SLC8A1 1 GO:0031643 positive regulation of myelination 1/502 18/18722 0.387039452100373 0.521083965487871 TNFRSF1B 1 GO:0034433 steroid esterification 1/502 18/18722 0.387039452100373 0.521083965487871 APOE 1 GO:0034434 sterol esterification 1/502 18/18722 0.387039452100373 0.521083965487871 APOE 1 GO:0034435 cholesterol esterification 1/502 18/18722 0.387039452100373 0.521083965487871 APOE 1 GO:0036507 protein demannosylation 1/502 18/18722 0.387039452100373 0.521083965487871 MAN1A1 1 GO:0036508 protein alpha-1,2-demannosylation 1/502 18/18722 0.387039452100373 0.521083965487871 MAN1A1 1 GO:0045116 protein neddylation 1/502 18/18722 0.387039452100373 0.521083965487871 HIF1A 1 GO:0048486 parasympathetic nervous system development 1/502 18/18722 0.387039452100373 0.521083965487871 NRP1 1 GO:0048535 lymph node development 1/502 18/18722 0.387039452100373 0.521083965487871 TGFB1 1 GO:0048643 positive regulation of skeletal muscle tissue development 1/502 18/18722 0.387039452100373 0.521083965487871 MEF2C 1 GO:0051782 negative regulation of cell division 1/502 18/18722 0.387039452100373 0.521083965487871 TXNIP 1 GO:0051895 negative regulation of focal adhesion assembly 1/502 18/18722 0.387039452100373 0.521083965487871 LRP1 1 GO:0055070 copper ion homeostasis 1/502 18/18722 0.387039452100373 0.521083965487871 PRNP 1 GO:0060008 Sertoli cell differentiation 1/502 18/18722 0.387039452100373 0.521083965487871 ICAM1 1 GO:0060438 trachea development 1/502 18/18722 0.387039452100373 0.521083965487871 TGFBR2 1 GO:0060749 mammary gland alveolus development 1/502 18/18722 0.387039452100373 0.521083965487871 HIF1A 1 GO:0060973 cell migration involved in heart development 1/502 18/18722 0.387039452100373 0.521083965487871 ENG 1 GO:0061377 mammary gland lobule development 1/502 18/18722 0.387039452100373 0.521083965487871 HIF1A 1 GO:0061484 hematopoietic stem cell homeostasis 1/502 18/18722 0.387039452100373 0.521083965487871 ADAR 1 GO:0071786 endoplasmic reticulum tubular network organization 1/502 18/18722 0.387039452100373 0.521083965487871 RTN4 1 GO:0072234 metanephric nephron tubule development 1/502 18/18722 0.387039452100373 0.521083965487871 STAT1 1 GO:0072662 protein localization to peroxisome 1/502 18/18722 0.387039452100373 0.521083965487871 RAB8B 1 GO:0072663 establishment of protein localization to peroxisome 1/502 18/18722 0.387039452100373 0.521083965487871 RAB8B 1 GO:0080182 histone H3-K4 trimethylation 1/502 18/18722 0.387039452100373 0.521083965487871 KMT2E 1 GO:0090493 catecholamine uptake 1/502 18/18722 0.387039452100373 0.521083965487871 ACTB 1 GO:0099558 maintenance of synapse structure 1/502 18/18722 0.387039452100373 0.521083965487871 CHCHD10 1 GO:0110154 RNA decapping 1/502 18/18722 0.387039452100373 0.521083965487871 ZFP36 1 GO:0150118 negative regulation of cell-substrate junction organization 1/502 18/18722 0.387039452100373 0.521083965487871 LRP1 1 GO:1901673 regulation of mitotic spindle assembly 1/502 18/18722 0.387039452100373 0.521083965487871 HSPA1A 1 GO:1902001 fatty acid transmembrane transport 1/502 18/18722 0.387039452100373 0.521083965487871 CD36 1 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 1/502 18/18722 0.387039452100373 0.521083965487871 RBPJ 1 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/502 50/18722 0.389282510716456 0.522734657351038 JAK2/NUPR1 2 GO:0038202 TORC1 signaling 2/502 50/18722 0.389282510716456 0.522734657351038 ATM/SESN1 2 GO:0042572 retinol metabolic process 2/502 50/18722 0.389282510716456 0.522734657351038 ALDH1A1/DHRS3 2 GO:0045814 negative regulation of gene expression, epigenetic 2/502 50/18722 0.389282510716456 0.522734657351038 SPI1/ATF7IP 2 GO:0051646 mitochondrion localization 2/502 50/18722 0.389282510716456 0.522734657351038 MEF2A/HIF1A 2 GO:0060425 lung morphogenesis 2/502 50/18722 0.389282510716456 0.522734657351038 CTSZ/TGFBR2 2 GO:1900047 negative regulation of hemostasis 2/502 50/18722 0.389282510716456 0.522734657351038 APOE/SERPING1 2 GO:1901570 fatty acid derivative biosynthetic process 2/502 50/18722 0.389282510716456 0.522734657351038 ALOX5/PPT1 2 GO:1902930 regulation of alcohol biosynthetic process 2/502 50/18722 0.389282510716456 0.522734657351038 APOE/PLEK 2 GO:0007613 memory 4/502 118/18722 0.390037709549133 0.523444863468028 LGMN/APOE/PRNP/SGK1 4 GO:1903313 positive regulation of mRNA metabolic process 4/502 118/18722 0.390037709549133 0.523444863468028 ZFP36L1/ZFP36/BTG2/ZFP36L2 4 GO:0006112 energy reserve metabolic process 3/502 84/18722 0.392323404511679 0.52620703661091 IGF1/PYGL/GAA 3 GO:0042310 vasoconstriction 3/502 84/18722 0.392323404511679 0.52620703661091 ICAM1/TBXAS1/SLC8A1 3 GO:0010906 regulation of glucose metabolic process 4/502 119/18722 0.396115832667629 0.531139664324769 IGF1/IGFBP4/PDK4/RANBP2 4 GO:0030856 regulation of epithelial cell differentiation 5/502 154/18722 0.396814776957079 0.531768585806328 SPRED1/ZFP36L1/ZFP36/TNFRSF1A/STAT1 5 GO:0051168 nuclear export 5/502 154/18722 0.396814776957079 0.531768585806328 GAS6/IFI27/TGFB1/SP100/AKAP13 5 GO:0048193 Golgi vesicle transport 9/502 296/18722 0.398391618100791 0.533331087219268 LAPTM5/MYO5A/VPS13C/EPS15/LAMP1/MACF1/GOLGA4/SNX2/RAB8B 9 GO:0014009 glial cell proliferation 2/502 51/18722 0.398787771442164 0.533331087219268 LYN/TSPO 2 GO:0021872 forebrain generation of neurons 2/502 51/18722 0.398787771442164 0.533331087219268 B2M/NRP1 2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 2/502 51/18722 0.398787771442164 0.533331087219268 PYCARD/STAT1 2 GO:0045104 intermediate filament cytoskeleton organization 2/502 51/18722 0.398787771442164 0.533331087219268 VIM/MACF1 2 GO:0048013 ephrin receptor signaling pathway 2/502 51/18722 0.398787771442164 0.533331087219268 RBPJ/LYN 2 GO:0051339 regulation of lyase activity 2/502 51/18722 0.398787771442164 0.533331087219268 TIMP2/GNAI2 2 GO:0009142 nucleoside triphosphate biosynthetic process 3/502 85/18722 0.399576526817293 0.533757073574796 TMSB4X/TGFB1/STAT3 3 GO:0044774 mitotic DNA integrity checkpoint signaling 3/502 85/18722 0.399576526817293 0.533757073574796 ATM/TAOK3/TAOK1 3 GO:0009755 hormone-mediated signaling pathway 6/502 190/18722 0.400899640191741 0.533757073574796 DAB2/JAK2/NCOA4/DDX17/DDX5/PRCP 6 GO:0090305 nucleic acid phosphodiester bond hydrolysis 8/502 261/18722 0.400986132313865 0.533757073574796 RNASE1/ENPP2/RNASE6/PLD3/RNASET2/SAMHD1/ZFP36/PLSCR1 8 GO:0006304 DNA modification 4/502 120/18722 0.402184229991467 0.533757073574796 SPI1/FOS/ATF7IP/KMT2E 4 GO:0001696 gastric acid secretion 1/502 19/18722 0.403490809833779 0.533757073574796 SGK1 1 GO:0006044 N-acetylglucosamine metabolic process 1/502 19/18722 0.403490809833779 0.533757073574796 GNPDA1 1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1/502 19/18722 0.403490809833779 0.533757073574796 ATM 1 GO:0007530 sex determination 1/502 19/18722 0.403490809833779 0.533757073574796 CITED2 1 GO:0008356 asymmetric cell division 1/502 19/18722 0.403490809833779 0.533757073574796 ACTR2 1 GO:0009081 branched-chain amino acid metabolic process 1/502 19/18722 0.403490809833779 0.533757073574796 BCAT1 1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 1/502 19/18722 0.403490809833779 0.533757073574796 TYMP 1 GO:0009226 nucleotide-sugar biosynthetic process 1/502 19/18722 0.403490809833779 0.533757073574796 GNPDA1 1 GO:0010002 cardioblast differentiation 1/502 19/18722 0.403490809833779 0.533757073574796 RBPJ 1 GO:0010544 negative regulation of platelet activation 1/502 19/18722 0.403490809833779 0.533757073574796 APOE 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/502 19/18722 0.403490809833779 0.533757073574796 KLF4 1 GO:0030011 maintenance of cell polarity 1/502 19/18722 0.403490809833779 0.533757073574796 NCKAP1L 1 GO:0031290 retinal ganglion cell axon guidance 1/502 19/18722 0.403490809833779 0.533757073574796 NRP1 1 GO:0032026 response to magnesium ion 1/502 19/18722 0.403490809833779 0.533757073574796 CD14 1 GO:0035461 vitamin transmembrane transport 1/502 19/18722 0.403490809833779 0.533757073574796 FOLR2 1 GO:0036498 IRE1-mediated unfolded protein response 1/502 19/18722 0.403490809833779 0.533757073574796 XBP1 1 GO:0038092 nodal signaling pathway 1/502 19/18722 0.403490809833779 0.533757073574796 CITED2 1 GO:0044320 cellular response to leptin stimulus 1/502 19/18722 0.403490809833779 0.533757073574796 STAT3 1 GO:0044827 modulation by host of viral genome replication 1/502 19/18722 0.403490809833779 0.533757073574796 IFI27 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/502 19/18722 0.403490809833779 0.533757073574796 ARRB2 1 GO:0051444 negative regulation of ubiquitin-protein transferase activity 1/502 19/18722 0.403490809833779 0.533757073574796 DTX3L 1 GO:0051546 keratinocyte migration 1/502 19/18722 0.403490809833779 0.533757073574796 ADAM9 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/502 19/18722 0.403490809833779 0.533757073574796 KMT2E 1 GO:0061323 cell proliferation involved in heart morphogenesis 1/502 19/18722 0.403490809833779 0.533757073574796 RBPJ 1 GO:0062099 negative regulation of programmed necrotic cell death 1/502 19/18722 0.403490809833779 0.533757073574796 NUPR1 1 GO:0070262 peptidyl-serine dephosphorylation 1/502 19/18722 0.403490809833779 0.533757073574796 DUSP1 1 GO:0072074 kidney mesenchyme development 1/502 19/18722 0.403490809833779 0.533757073574796 STAT1 1 GO:0072077 renal vesicle morphogenesis 1/502 19/18722 0.403490809833779 0.533757073574796 STAT1 1 GO:0098780 response to mitochondrial depolarisation 1/502 19/18722 0.403490809833779 0.533757073574796 VPS13C 1 GO:1901881 positive regulation of protein depolymerization 1/502 19/18722 0.403490809833779 0.533757073574796 PLEK 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/502 19/18722 0.403490809833779 0.533757073574796 NRP1 1 GO:2000269 regulation of fibroblast apoptotic process 1/502 19/18722 0.403490809833779 0.533757073574796 GAS6 1 GO:2000319 regulation of T-helper 17 cell differentiation 1/502 19/18722 0.403490809833779 0.533757073574796 NFKBIZ 1 GO:0006164 purine nucleotide biosynthetic process 6/502 191/18722 0.405688062781493 0.536510285428013 TMSB4X/PDK4/PPT1/TGFB1/STAT3/ADCY7 6 GO:0014031 mesenchymal cell development 3/502 86/18722 0.40680554349175 0.537680698340811 NRP1/HIF1A/CITED2 3 GO:0015908 fatty acid transport 3/502 86/18722 0.40680554349175 0.537680698340811 APOE/CD36/SYK 3 GO:0010662 regulation of striated muscle cell apoptotic process 2/502 52/18722 0.408223500353298 0.539116658260738 JAK2/NUPR1 2 GO:0045103 intermediate filament-based process 2/502 52/18722 0.408223500353298 0.539116658260738 VIM/MACF1 2 GO:0042177 negative regulation of protein catabolic process 4/502 121/18722 0.408241602656153 0.539116658260738 TIMP2/CST3/SDCBP/TIMP1 4 GO:0016101 diterpenoid metabolic process 3/502 87/18722 0.414008505811555 0.546576297912173 ALDH1A1/DHRS3/LRP1 3 GO:0050819 negative regulation of coagulation 2/502 53/18722 0.417586591087511 0.546651791178843 APOE/SERPING1 2 GO:0051438 regulation of ubiquitin-protein transferase activity 2/502 53/18722 0.417586591087511 0.546651791178843 DTX3L/FEM1B 2 GO:0099172 presynapse organization 2/502 53/18722 0.417586591087511 0.546651791178843 C5AR1/SDCBP 2 GO:1990090 cellular response to nerve growth factor stimulus 2/502 53/18722 0.417586591087511 0.546651791178843 FOXO3/ACAP2 2 GO:2000772 regulation of cellular senescence 2/502 53/18722 0.417586591087511 0.546651791178843 B2M/NAMPT 2 GO:0043488 regulation of mRNA stability 5/502 158/18722 0.418056266034495 0.546651791178843 ZFP36L1/ZFP36/BTG2/VIM/ZFP36L2 5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/502 20/18722 0.419501482638326 0.546651791178843 RB1 1 GO:0001832 blastocyst growth 1/502 20/18722 0.419501482638326 0.546651791178843 IGF1 1 GO:0002115 store-operated calcium entry 1/502 20/18722 0.419501482638326 0.546651791178843 CD84 1 GO:0006346 DNA methylation-dependent heterochromatin assembly 1/502 20/18722 0.419501482638326 0.546651791178843 ATF7IP 1 GO:0006590 thyroid hormone generation 1/502 20/18722 0.419501482638326 0.546651791178843 CTSB 1 GO:0006607 NLS-bearing protein import into nucleus 1/502 20/18722 0.419501482638326 0.546651791178843 RANBP2 1 GO:0006837 serotonin transport 1/502 20/18722 0.419501482638326 0.546651791178843 SYK 1 GO:0007194 negative regulation of adenylate cyclase activity 1/502 20/18722 0.419501482638326 0.546651791178843 GNAI2 1 GO:0009110 vitamin biosynthetic process 1/502 20/18722 0.419501482638326 0.546651791178843 PLTP 1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 1/502 20/18722 0.419501482638326 0.546651791178843 TYMP 1 GO:0009713 catechol-containing compound biosynthetic process 1/502 20/18722 0.419501482638326 0.546651791178843 NR4A2 1 GO:0015919 peroxisomal membrane transport 1/502 20/18722 0.419501482638326 0.546651791178843 RAB8B 1 GO:0016553 base conversion or substitution editing 1/502 20/18722 0.419501482638326 0.546651791178843 ADAR 1 GO:0017121 plasma membrane phospholipid scrambling 1/502 20/18722 0.419501482638326 0.546651791178843 PLSCR1 1 GO:0031645 negative regulation of nervous system process 1/502 20/18722 0.419501482638326 0.546651791178843 CTSC 1 GO:0032495 response to muramyl dipeptide 1/502 20/18722 0.419501482638326 0.546651791178843 VIM 1 GO:0033005 positive regulation of mast cell activation 1/502 20/18722 0.419501482638326 0.546651791178843 SYK 1 GO:0034104 negative regulation of tissue remodeling 1/502 20/18722 0.419501482638326 0.546651791178843 CST3 1 GO:0042359 vitamin D metabolic process 1/502 20/18722 0.419501482638326 0.546651791178843 LGMN 1 GO:0042423 catecholamine biosynthetic process 1/502 20/18722 0.419501482638326 0.546651791178843 NR4A2 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/502 20/18722 0.419501482638326 0.546651791178843 ITM2B 1 GO:0043651 linoleic acid metabolic process 1/502 20/18722 0.419501482638326 0.546651791178843 ALOX5 1 GO:0045844 positive regulation of striated muscle tissue development 1/502 20/18722 0.419501482638326 0.546651791178843 MEF2C 1 GO:0048636 positive regulation of muscle organ development 1/502 20/18722 0.419501482638326 0.546651791178843 MEF2C 1 GO:0051900 regulation of mitochondrial depolarization 1/502 20/18722 0.419501482638326 0.546651791178843 TSPO 1 GO:0060231 mesenchymal to epithelial transition 1/502 20/18722 0.419501482638326 0.546651791178843 STAT1 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/502 20/18722 0.419501482638326 0.546651791178843 ACTR2 1 GO:0061318 renal filtration cell differentiation 1/502 20/18722 0.419501482638326 0.546651791178843 IQGAP1 1 GO:0071379 cellular response to prostaglandin stimulus 1/502 20/18722 0.419501482638326 0.546651791178843 PTGER4 1 GO:0071397 cellular response to cholesterol 1/502 20/18722 0.419501482638326 0.546651791178843 ABCA1 1 GO:0072087 renal vesicle development 1/502 20/18722 0.419501482638326 0.546651791178843 STAT1 1 GO:0072112 glomerular visceral epithelial cell differentiation 1/502 20/18722 0.419501482638326 0.546651791178843 IQGAP1 1 GO:0097150 neuronal stem cell population maintenance 1/502 20/18722 0.419501482638326 0.546651791178843 FOXO3 1 GO:0097503 sialylation 1/502 20/18722 0.419501482638326 0.546651791178843 ST8SIA4 1 GO:1904292 regulation of ERAD pathway 1/502 20/18722 0.419501482638326 0.546651791178843 HERPUD1 1 GO:1990182 exosomal secretion 1/502 20/18722 0.419501482638326 0.546651791178843 SDCBP 1 GO:2000010 positive regulation of protein localization to cell surface 1/502 20/18722 0.419501482638326 0.546651791178843 TYROBP 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/502 20/18722 0.419501482638326 0.546651791178843 PRKAR1A 1 GO:2000678 negative regulation of transcription regulatory region DNA binding 1/502 20/18722 0.419501482638326 0.546651791178843 TMSB4X 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/502 20/18722 0.419501482638326 0.546651791178843 SPI1 1 GO:0031570 DNA integrity checkpoint signaling 4/502 123/18722 0.420318223356317 0.5475618420857 ATM/TAOK3/FEM1B/TAOK1 4 GO:0072001 renal system development 9/502 302/18722 0.421335823191664 0.548732972433738 MEF2C/PLXND1/MTSS1/PECAM1/NRP1/EGR1/IQGAP1/AP1B1/STAT1 9 GO:0046488 phosphatidylinositol metabolic process 5/502 159/18722 0.423349049753318 0.551199747863453 CSF1R/PLEK/ATM/PIK3R1/EFR3A 5 GO:0030705 cytoskeleton-dependent intracellular transport 6/502 195/18722 0.424806136937954 0.552941246335109 MYO5A/CCDC88A/TUBA1A/MYO1F/LAMP1/HIF1A 6 GO:0009132 nucleoside diphosphate metabolic process 4/502 124/18722 0.426335018705915 0.554696582107679 IGF1/NUPR1/STAT3/HIF1A 4 GO:0001706 endoderm formation 2/502 54/18722 0.426874153113562 0.554696582107679 ITGB2/DUSP1 2 GO:0007215 glutamate receptor signaling pathway 2/502 54/18722 0.426874153113562 0.554696582107679 PRNP/CPEB4 2 GO:0010659 cardiac muscle cell apoptotic process 2/502 54/18722 0.426874153113562 0.554696582107679 JAK2/NUPR1 2 GO:0032330 regulation of chondrocyte differentiation 2/502 54/18722 0.426874153113562 0.554696582107679 MAF/TRPS1 2 GO:0060350 endochondral bone morphogenesis 2/502 54/18722 0.426874153113562 0.554696582107679 MEF2C/TGFBR2 2 GO:0006006 glucose metabolic process 6/502 196/18722 0.429573441726134 0.558047385966047 IGF1/IGFBP4/PDK4/OAS1/GAA/RANBP2 6 GO:0006310 DNA recombination 9/502 305/18722 0.432798178313889 0.560015338068127 CD28/PTPRC/SAMHD1/ATM/ACTR2/WAS/NABP1/TGFB1/SETX 9 GO:0003091 renal water homeostasis 1/502 21/18722 0.435083252273421 0.560015338068127 PRKACB 1 GO:0006244 pyrimidine nucleotide catabolic process 1/502 21/18722 0.435083252273421 0.560015338068127 TYMP 1 GO:0006353 DNA-templated transcription, termination 1/502 21/18722 0.435083252273421 0.560015338068127 SETX 1 GO:0006925 inflammatory cell apoptotic process 1/502 21/18722 0.435083252273421 0.560015338068127 MEF2C 1 GO:0007063 regulation of sister chromatid cohesion 1/502 21/18722 0.435083252273421 0.560015338068127 RB1 1 GO:0007350 blastoderm segmentation 1/502 21/18722 0.435083252273421 0.560015338068127 NRP1 1 GO:0032288 myelin assembly 1/502 21/18722 0.435083252273421 0.560015338068127 PMP22 1 GO:0032303 regulation of icosanoid secretion 1/502 21/18722 0.435083252273421 0.560015338068127 SYK 1 GO:0032482 Rab protein signal transduction 1/502 21/18722 0.435083252273421 0.560015338068127 DENND3 1 GO:0035813 regulation of renal sodium excretion 1/502 21/18722 0.435083252273421 0.560015338068127 GNAI2 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/502 21/18722 0.435083252273421 0.560015338068127 IQGAP1 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/502 21/18722 0.435083252273421 0.560015338068127 STAT3 1 GO:0044241 lipid digestion 1/502 21/18722 0.435083252273421 0.560015338068127 CD36 1 GO:0048485 sympathetic nervous system development 1/502 21/18722 0.435083252273421 0.560015338068127 NRP1 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/502 21/18722 0.435083252273421 0.560015338068127 TNFRSF1B 1 GO:0048745 smooth muscle tissue development 1/502 21/18722 0.435083252273421 0.560015338068127 ENG 1 GO:0060117 auditory receptor cell development 1/502 21/18722 0.435083252273421 0.560015338068127 SLC4A7 1 GO:0060972 left/right pattern formation 1/502 21/18722 0.435083252273421 0.560015338068127 CITED2 1 GO:0070269 pyroptosis 1/502 21/18722 0.435083252273421 0.560015338068127 NAIP 1 GO:0072170 metanephric tubule development 1/502 21/18722 0.435083252273421 0.560015338068127 STAT1 1 GO:0072243 metanephric nephron epithelium development 1/502 21/18722 0.435083252273421 0.560015338068127 STAT1 1 GO:0072311 glomerular epithelial cell differentiation 1/502 21/18722 0.435083252273421 0.560015338068127 IQGAP1 1 GO:0097734 extracellular exosome biogenesis 1/502 21/18722 0.435083252273421 0.560015338068127 SDCBP 1 GO:0098856 intestinal lipid absorption 1/502 21/18722 0.435083252273421 0.560015338068127 CD36 1 GO:1901863 positive regulation of muscle tissue development 1/502 21/18722 0.435083252273421 0.560015338068127 MEF2C 1 GO:1902307 positive regulation of sodium ion transmembrane transport 1/502 21/18722 0.435083252273421 0.560015338068127 ATP1B1 1 GO:1902473 regulation of protein localization to synapse 1/502 21/18722 0.435083252273421 0.560015338068127 ADAM10 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/502 21/18722 0.435083252273421 0.560015338068127 STAT3 1 GO:1903429 regulation of cell maturation 1/502 21/18722 0.435083252273421 0.560015338068127 CLEC7A 1 GO:2000178 negative regulation of neural precursor cell proliferation 1/502 21/18722 0.435083252273421 0.560015338068127 BTG2 1 GO:2000291 regulation of myoblast proliferation 1/502 21/18722 0.435083252273421 0.560015338068127 MALAT1 1 GO:2000774 positive regulation of cellular senescence 1/502 21/18722 0.435083252273421 0.560015338068127 B2M 1 GO:0002028 regulation of sodium ion transport 3/502 90/18722 0.435442600655727 0.56016614867447 ATP1B1/SLC8A1/FXYD5 3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 3/502 90/18722 0.435442600655727 0.56016614867447 DAB2/HSPA1A/HERPUD1 3 GO:0001755 neural crest cell migration 2/502 55/18722 0.43608350243095 0.560523001457509 NRP1/HIF1A 2 GO:0042220 response to cocaine 2/502 55/18722 0.43608350243095 0.560523001457509 HNMT/SLC1A3 2 GO:0051898 negative regulation of protein kinase B signaling 2/502 55/18722 0.43608350243095 0.560523001457509 ARRB2/KLF4 2 GO:0009117 nucleotide metabolic process 14/502 489/18722 0.43951939621676 0.564782424138536 IGF1/TMSB4X/SAMHD1/TYMP/PARP9/NAMPT/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 14 GO:0019935 cyclic-nucleotide-mediated signaling 3/502 91/18722 0.44252321391914 0.568168855839562 APOE/CD36/AHR 3 GO:0042147 retrograde transport, endosome to Golgi 3/502 91/18722 0.44252321391914 0.568168855839562 CLTC/SNX6/SNX2 3 GO:0072080 nephron tubule development 3/502 91/18722 0.44252321391914 0.568168855839562 MEF2C/MTSS1/STAT1 3 GO:0016311 dephosphorylation 12/502 417/18722 0.442845946780555 0.568425457771046 MEF2C/PLEK/NCKAP1L/PTPRC/JAK2/DUSP1/ACP5/TGFB1/PTPN6/GNAI2/DUSP3/CALM2 12 GO:0048565 digestive tract development 4/502 127/18722 0.444285240047545 0.570114707478486 PDGFC/RB1/TGFBR2/HIF1A 4 GO:0006687 glycosphingolipid metabolic process 2/502 56/18722 0.445212152611497 0.570173921000367 ST8SIA4/HEXA 2 GO:0010658 striated muscle cell apoptotic process 2/502 56/18722 0.445212152611497 0.570173921000367 JAK2/NUPR1 2 GO:0030166 proteoglycan biosynthetic process 2/502 56/18722 0.445212152611497 0.570173921000367 IGF1/DSE 2 GO:0045599 negative regulation of fat cell differentiation 2/502 56/18722 0.445212152611497 0.570173921000367 ZFP36L2/TGFB1 2 GO:1990089 response to nerve growth factor 2/502 56/18722 0.445212152611497 0.570173921000367 FOXO3/ACAP2 2 GO:0072522 purine-containing compound biosynthetic process 6/502 200/18722 0.448574612411307 0.570173921000367 TMSB4X/PDK4/PPT1/TGFB1/STAT3/ADCY7 6 GO:0099003 vesicle-mediated transport in synapse 6/502 200/18722 0.448574612411307 0.570173921000367 ITSN1/ACTB/EPS15/ITSN2/CYFIP1/FCHO2 6 GO:0006497 protein lipidation 3/502 92/18722 0.449569038144675 0.570173921000367 ABCA1/ATG7/GLUL 3 GO:0034502 protein localization to chromosome 3/502 92/18722 0.449569038144675 0.570173921000367 TPP1/RB1/SPI1 3 GO:0035249 synaptic transmission, glutamatergic 3/502 92/18722 0.449569038144675 0.570173921000367 MEF2C/CCL2/GLUL 3 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 5/502 164/18722 0.449664674514073 0.570173921000367 DAB2/LAPTM5/HSPA1A/SDCBP/HERPUD1 5 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 1/502 22/18722 0.45024758612502 0.570173921000367 ARRB2 1 GO:0002089 lens morphogenesis in camera-type eye 1/502 22/18722 0.45024758612502 0.570173921000367 CITED2 1 GO:0002320 lymphoid progenitor cell differentiation 1/502 22/18722 0.45024758612502 0.570173921000367 SPI1 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/502 22/18722 0.45024758612502 0.570173921000367 FOLR2 1 GO:0009190 cyclic nucleotide biosynthetic process 1/502 22/18722 0.45024758612502 0.570173921000367 ADCY7 1 GO:0016137 glycoside metabolic process 1/502 22/18722 0.45024758612502 0.570173921000367 FUCA1 1 GO:0021854 hypothalamus development 1/502 22/18722 0.45024758612502 0.570173921000367 NRP1 1 GO:0021904 dorsal/ventral neural tube patterning 1/502 22/18722 0.45024758612502 0.570173921000367 PRKACB 1 GO:0022401 negative adaptation of signaling pathway 1/502 22/18722 0.45024758612502 0.570173921000367 ARRB2 1 GO:0030277 maintenance of gastrointestinal epithelium 1/502 22/18722 0.45024758612502 0.570173921000367 TLR4 1 GO:0031281 positive regulation of cyclase activity 1/502 22/18722 0.45024758612502 0.570173921000367 TIMP2 1 GO:0032402 melanosome transport 1/502 22/18722 0.45024758612502 0.570173921000367 MYO5A 1 GO:0034629 cellular protein-containing complex localization 1/502 22/18722 0.45024758612502 0.570173921000367 TNFAIP2 1 GO:0035089 establishment of apical/basal cell polarity 1/502 22/18722 0.45024758612502 0.570173921000367 MSN 1 GO:0035357 peroxisome proliferator activated receptor signaling pathway 1/502 22/18722 0.45024758612502 0.570173921000367 CITED2 1 GO:0035809 regulation of urine volume 1/502 22/18722 0.45024758612502 0.570173921000367 GNAI2 1 GO:0036120 cellular response to platelet-derived growth factor stimulus 1/502 22/18722 0.45024758612502 0.570173921000367 TLR4 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/502 22/18722 0.45024758612502 0.570173921000367 RUNX1 1 GO:0043574 peroxisomal transport 1/502 22/18722 0.45024758612502 0.570173921000367 RAB8B 1 GO:0044346 fibroblast apoptotic process 1/502 22/18722 0.45024758612502 0.570173921000367 GAS6 1 GO:0045048 protein insertion into ER membrane 1/502 22/18722 0.45024758612502 0.570173921000367 TRAM1 1 GO:0045540 regulation of cholesterol biosynthetic process 1/502 22/18722 0.45024758612502 0.570173921000367 APOE 1 GO:0045663 positive regulation of myoblast differentiation 1/502 22/18722 0.45024758612502 0.570173921000367 MEF2C 1 GO:0046058 cAMP metabolic process 1/502 22/18722 0.45024758612502 0.570173921000367 ADCY7 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/502 22/18722 0.45024758612502 0.570173921000367 GNAI2 1 GO:0051220 cytoplasmic sequestering of protein 1/502 22/18722 0.45024758612502 0.570173921000367 TMSB4X 1 GO:0052652 cyclic purine nucleotide metabolic process 1/502 22/18722 0.45024758612502 0.570173921000367 ADCY7 1 GO:0055093 response to hyperoxia 1/502 22/18722 0.45024758612502 0.570173921000367 ATG7 1 GO:0060713 labyrinthine layer morphogenesis 1/502 22/18722 0.45024758612502 0.570173921000367 ZFP36L1 1 GO:0071467 cellular response to pH 1/502 22/18722 0.45024758612502 0.570173921000367 MCOLN1 1 GO:0072574 hepatocyte proliferation 1/502 22/18722 0.45024758612502 0.570173921000367 XBP1 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/502 22/18722 0.45024758612502 0.570173921000367 XBP1 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/502 22/18722 0.45024758612502 0.570173921000367 SLC8A1 1 GO:0097164 ammonium ion metabolic process 1/502 22/18722 0.45024758612502 0.570173921000367 HNMT 1 GO:0106118 regulation of sterol biosynthetic process 1/502 22/18722 0.45024758612502 0.570173921000367 APOE 1 GO:2000114 regulation of establishment of cell polarity 1/502 22/18722 0.45024758612502 0.570173921000367 GSN 1 GO:2000773 negative regulation of cellular senescence 1/502 22/18722 0.45024758612502 0.570173921000367 NAMPT 1 GO:0019318 hexose metabolic process 7/502 237/18722 0.451586892845022 0.571713455473748 IGF1/IGFBP4/PDK4/OAS1/FUCA1/GAA/RANBP2 7 GO:0050879 multicellular organismal movement 2/502 57/18722 0.454257806171271 0.574623082129696 NR4A1/GAA 2 GO:0050881 musculoskeletal movement 2/502 57/18722 0.454257806171271 0.574623082129696 NR4A1/GAA 2 GO:1900024 regulation of substrate adhesion-dependent cell spreading 2/502 57/18722 0.454257806171271 0.574623082129696 NRP1/PREX1 2 GO:0046661 male sex differentiation 5/502 165/18722 0.45489244901176 0.575268580953636 ICAM1/LHFPL2/NUPR1/NCOA4/CITED2 5 GO:1901019 regulation of calcium ion transmembrane transporter activity 3/502 93/18722 0.456578521767894 0.57708531193942 ATP1B1/VMP1/CALM2 3 GO:1901992 positive regulation of mitotic cell cycle phase transition 3/502 93/18722 0.456578521767894 0.57708531193942 AIF1/RB1/KMT2E 3 GO:0061013 regulation of mRNA catabolic process 5/502 166/18722 0.4601066154781 0.578723733237146 ZFP36L1/ZFP36/BTG2/VIM/ZFP36L2 5 GO:0007548 sex differentiation 8/502 276/18722 0.461952105781843 0.578723733237146 ICAM1/ARRB2/LHFPL2/FOXO3/NRIP1/NUPR1/NCOA4/CITED2 8 GO:0006282 regulation of DNA repair 4/502 130/18722 0.462061905698908 0.578723733237146 PARP9/ACTR2/DTX3L/WAS 4 GO:0030534 adult behavior 4/502 130/18722 0.462061905698908 0.578723733237146 NR4A2/ARRB2/PPT1/EPS8 4 GO:0007405 neuroblast proliferation 2/502 58/18722 0.46321834626164 0.578723733237146 HIF1A/PLXNB2 2 GO:0010043 response to zinc ion 2/502 58/18722 0.46321834626164 0.578723733237146 SOD2/TSPO 2 GO:0010559 regulation of glycoprotein biosynthetic process 2/502 58/18722 0.46321834626164 0.578723733237146 IGF1/ITM2B 2 GO:0032387 negative regulation of intracellular transport 2/502 58/18722 0.46321834626164 0.578723733237146 CD36/SP100 2 GO:0043506 regulation of JUN kinase activity 2/502 58/18722 0.46321834626164 0.578723733237146 SYK/TAOK3 2 GO:0045604 regulation of epidermal cell differentiation 2/502 58/18722 0.46321834626164 0.578723733237146 ZFP36L1/ZFP36 2 GO:1902808 positive regulation of cell cycle G1/S phase transition 2/502 58/18722 0.46321834626164 0.578723733237146 AIF1/KMT2E 2 GO:2000649 regulation of sodium ion transmembrane transporter activity 2/502 58/18722 0.46321834626164 0.578723733237146 ATP1B1/FXYD5 2 GO:0001738 morphogenesis of a polarized epithelium 3/502 94/18722 0.463550176055151 0.578723733237146 DAB2/ACTB/MSN 3 GO:0061326 renal tubule development 3/502 94/18722 0.463550176055151 0.578723733237146 MEF2C/MTSS1/STAT1 3 GO:1902414 protein localization to cell junction 3/502 94/18722 0.463550176055151 0.578723733237146 PECAM1/ACTB/ADAM10 3 GO:0006753 nucleoside phosphate metabolic process 14/502 497/18722 0.463700866583073 0.578723733237146 IGF1/TMSB4X/SAMHD1/TYMP/PARP9/NAMPT/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 14 GO:0001919 regulation of receptor recycling 1/502 23/18722 0.465005645577706 0.578723733237146 EPS15 1 GO:0002052 positive regulation of neuroblast proliferation 1/502 23/18722 0.465005645577706 0.578723733237146 HIF1A 1 GO:0002082 regulation of oxidative phosphorylation 1/502 23/18722 0.465005645577706 0.578723733237146 NUPR1 1 GO:0002363 alpha-beta T cell lineage commitment 1/502 23/18722 0.465005645577706 0.578723733237146 STAT3 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/502 23/18722 0.465005645577706 0.578723733237146 TYMP 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/502 23/18722 0.465005645577706 0.578723733237146 LRP1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/502 23/18722 0.465005645577706 0.578723733237146 GAS6 1 GO:0010888 negative regulation of lipid storage 1/502 23/18722 0.465005645577706 0.578723733237146 ABCA1 1 GO:0018279 protein N-linked glycosylation via asparagine 1/502 23/18722 0.465005645577706 0.578723733237146 MGAT1 1 GO:0021884 forebrain neuron development 1/502 23/18722 0.465005645577706 0.578723733237146 NRP1 1 GO:0023058 adaptation of signaling pathway 1/502 23/18722 0.465005645577706 0.578723733237146 ARRB2 1 GO:0030194 positive regulation of blood coagulation 1/502 23/18722 0.465005645577706 0.578723733237146 CD36 1 GO:0031280 negative regulation of cyclase activity 1/502 23/18722 0.465005645577706 0.578723733237146 GNAI2 1 GO:0032401 establishment of melanosome localization 1/502 23/18722 0.465005645577706 0.578723733237146 MYO5A 1 GO:0032740 positive regulation of interleukin-17 production 1/502 23/18722 0.465005645577706 0.578723733237146 TGFB1 1 GO:0034695 response to prostaglandin E 1/502 23/18722 0.465005645577706 0.578723733237146 PTGER4 1 GO:0035640 exploration behavior 1/502 23/18722 0.465005645577706 0.578723733237146 APOE 1 GO:0035812 renal sodium excretion 1/502 23/18722 0.465005645577706 0.578723733237146 GNAI2 1 GO:0036119 response to platelet-derived growth factor 1/502 23/18722 0.465005645577706 0.578723733237146 TLR4 1 GO:0042438 melanin biosynthetic process 1/502 23/18722 0.465005645577706 0.578723733237146 ZEB2 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/502 23/18722 0.465005645577706 0.578723733237146 STAT3 1 GO:0043931 ossification involved in bone maturation 1/502 23/18722 0.465005645577706 0.578723733237146 IGF1 1 GO:0045662 negative regulation of myoblast differentiation 1/502 23/18722 0.465005645577706 0.578723733237146 TGFB1 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/502 23/18722 0.465005645577706 0.578723733237146 CD74 1 GO:0045724 positive regulation of cilium assembly 1/502 23/18722 0.465005645577706 0.578723733237146 CCDC88A 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/502 23/18722 0.465005645577706 0.578723733237146 DSE 1 GO:0051131 chaperone-mediated protein complex assembly 1/502 23/18722 0.465005645577706 0.578723733237146 HSPA1A 1 GO:0051349 positive regulation of lyase activity 1/502 23/18722 0.465005645577706 0.578723733237146 TIMP2 1 GO:0051882 mitochondrial depolarization 1/502 23/18722 0.465005645577706 0.578723733237146 TSPO 1 GO:0051904 pigment granule transport 1/502 23/18722 0.465005645577706 0.578723733237146 MYO5A 1 GO:0060353 regulation of cell adhesion molecule production 1/502 23/18722 0.465005645577706 0.578723733237146 COLEC12 1 GO:0060384 innervation 1/502 23/18722 0.465005645577706 0.578723733237146 NRP1 1 GO:0060547 negative regulation of necrotic cell death 1/502 23/18722 0.465005645577706 0.578723733237146 NUPR1 1 GO:0060575 intestinal epithelial cell differentiation 1/502 23/18722 0.465005645577706 0.578723733237146 HIF1A 1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 1/502 23/18722 0.465005645577706 0.578723733237146 IGF1 1 GO:0072576 liver morphogenesis 1/502 23/18722 0.465005645577706 0.578723733237146 XBP1 1 GO:0090335 regulation of brown fat cell differentiation 1/502 23/18722 0.465005645577706 0.578723733237146 METRNL 1 GO:0099590 neurotransmitter receptor internalization 1/502 23/18722 0.465005645577706 0.578723733237146 EPS15 1 GO:0140112 extracellular vesicle biogenesis 1/502 23/18722 0.465005645577706 0.578723733237146 SDCBP 1 GO:1900048 positive regulation of hemostasis 1/502 23/18722 0.465005645577706 0.578723733237146 CD36 1 GO:1900273 positive regulation of long-term synaptic potentiation 1/502 23/18722 0.465005645577706 0.578723733237146 LGMN 1 GO:0032768 regulation of monooxygenase activity 2/502 59/18722 0.472091828668605 0.587226888792946 APOE/HIF1A 2 GO:0048010 vascular endothelial growth factor receptor signaling pathway 2/502 59/18722 0.472091828668605 0.587226888792946 NRP1/HIF1A 2 GO:0045667 regulation of osteoblast differentiation 4/502 132/18722 0.473802666005811 0.589196541113678 MEF2C/IGF1/DDX5/ATP6AP1 4 GO:0006066 alcohol metabolic process 10/502 353/18722 0.475006388119917 0.589462447847919 IGF1/APOE/PLEK/ALDH1A1/NPC2/ABCA1/ASAH1/SPTLC2/DHRS3/ACER3 10 GO:0051656 establishment of organelle localization 11/502 390/18722 0.475303220633987 0.589462447847919 CD84/LGALS9/MYO5A/SYK/LYN/ACTR2/MYO1F/LAMP1/FAM91A1/HIF1A/ATP6AP1 11 GO:0048568 embryonic organ development 12/502 427/18722 0.475514123532878 0.589462447847919 MEF2C/PDGFC/MAFB/ZFP36L1/RBPJ/JUNB/TGFBR2/ENG/TGFB1/HIF1A/CITED2/STK4 12 GO:0021543 pallium development 5/502 169/18722 0.475660040452929 0.589462447847919 BTG2/HIF1A/RTN4/TACC1/LRP1 5 GO:0010769 regulation of cell morphogenesis involved in differentiation 3/502 96/18722 0.477374349595533 0.589462447847919 NRP1/PREX1/ACTR2 3 GO:0030510 regulation of BMP signaling pathway 3/502 96/18722 0.477374349595533 0.589462447847919 RBPJ/ENG/SKIL 3 GO:0043648 dicarboxylic acid metabolic process 3/502 96/18722 0.477374349595533 0.589462447847919 GLUL/GLS/ME2 3 GO:0044264 cellular polysaccharide metabolic process 3/502 96/18722 0.477374349595533 0.589462447847919 IGF1/PYGL/GAA 3 GO:0015711 organic anion transport 10/502 354/18722 0.47857736960364 0.589462447847919 FOLR2/SLCO2B1/CR1/CD36/PSAP/SYK/SLC2A3/EMB/SLC1A3/SLC4A7 10 GO:0001702 gastrulation with mouth forming second 1/502 24/18722 0.479368294164261 0.589462447847919 ETS2 1 GO:0002021 response to dietary excess 1/502 24/18722 0.479368294164261 0.589462447847919 APOE 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/502 24/18722 0.479368294164261 0.589462447847919 TLR4 1 GO:0003181 atrioventricular valve morphogenesis 1/502 24/18722 0.479368294164261 0.589462447847919 TGFBR2 1 GO:0006213 pyrimidine nucleoside metabolic process 1/502 24/18722 0.479368294164261 0.589462447847919 TYMP 1 GO:0006582 melanin metabolic process 1/502 24/18722 0.479368294164261 0.589462447847919 ZEB2 1 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 1/502 24/18722 0.479368294164261 0.589462447847919 TYMP 1 GO:0010155 regulation of proton transport 1/502 24/18722 0.479368294164261 0.589462447847919 TMSB4X 1 GO:0010226 response to lithium ion 1/502 24/18722 0.479368294164261 0.589462447847919 ADCY7 1 GO:0010288 response to lead ion 1/502 24/18722 0.479368294164261 0.589462447847919 PLSCR1 1 GO:0016048 detection of temperature stimulus 1/502 24/18722 0.479368294164261 0.589462447847919 ARRB2 1 GO:0018196 peptidyl-asparagine modification 1/502 24/18722 0.479368294164261 0.589462447847919 MGAT1 1 GO:0021801 cerebral cortex radial glia-guided migration 1/502 24/18722 0.479368294164261 0.589462447847919 RTN4 1 GO:0022030 telencephalon glial cell migration 1/502 24/18722 0.479368294164261 0.589462447847919 RTN4 1 GO:0030859 polarized epithelial cell differentiation 1/502 24/18722 0.479368294164261 0.589462447847919 MSN 1 GO:0032528 microvillus organization 1/502 24/18722 0.479368294164261 0.589462447847919 FXYD5 1 GO:0033032 regulation of myeloid cell apoptotic process 1/502 24/18722 0.479368294164261 0.589462447847919 MEF2C 1 GO:0044062 regulation of excretion 1/502 24/18722 0.479368294164261 0.589462447847919 GNAI2 1 GO:0044321 response to leptin 1/502 24/18722 0.479368294164261 0.589462447847919 STAT3 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/502 24/18722 0.479368294164261 0.589462447847919 CYFIP1 1 GO:0050687 negative regulation of defense response to virus 1/502 24/18722 0.479368294164261 0.589462447847919 FGL2 1 GO:0050820 positive regulation of coagulation 1/502 24/18722 0.479368294164261 0.589462447847919 CD36 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/502 24/18722 0.479368294164261 0.589462447847919 ATF7IP 1 GO:0051905 establishment of pigment granule localization 1/502 24/18722 0.479368294164261 0.589462447847919 MYO5A 1 GO:0060571 morphogenesis of an epithelial fold 1/502 24/18722 0.479368294164261 0.589462447847919 HIF1A 1 GO:0061162 establishment of monopolar cell polarity 1/502 24/18722 0.479368294164261 0.589462447847919 MSN 1 GO:0070841 inclusion body assembly 1/502 24/18722 0.479368294164261 0.589462447847919 HSPA1A 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/502 24/18722 0.479368294164261 0.589462447847919 ZFP36 1 GO:0071294 cellular response to zinc ion 1/502 24/18722 0.479368294164261 0.589462447847919 TSPO 1 GO:0090343 positive regulation of cell aging 1/502 24/18722 0.479368294164261 0.589462447847919 B2M 1 GO:0120255 olefinic compound biosynthetic process 1/502 24/18722 0.479368294164261 0.589462447847919 EGR1 1 GO:1901984 negative regulation of protein acetylation 1/502 24/18722 0.479368294164261 0.589462447847919 SPI1 1 GO:1903861 positive regulation of dendrite extension 1/502 24/18722 0.479368294164261 0.589462447847919 ITSN2 1 GO:0006893 Golgi to plasma membrane transport 2/502 60/18722 0.480876474109893 0.590532139429882 MACF1/GOLGA4 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/502 60/18722 0.480876474109893 0.590532139429882 PDK4/PPT1 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/502 60/18722 0.480876474109893 0.590532139429882 PDK4/PPT1 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/502 60/18722 0.480876474109893 0.590532139429882 PDK4/PPT1 2 GO:0061951 establishment of protein localization to plasma membrane 2/502 60/18722 0.480876474109893 0.590532139429882 MACF1/GOLGA4 2 GO:0006721 terpenoid metabolic process 3/502 97/18722 0.484224196093448 0.59448543819753 ALDH1A1/DHRS3/LRP1 3 GO:0001508 action potential 4/502 134/18722 0.485446065246439 0.595669362819636 SCN9A/ATP1B1/CD36/SLC8A1 4 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 4/502 134/18722 0.485446065246439 0.595669362819636 DAB2/HSPA1A/SDCBP/HERPUD1 4 GO:0008202 steroid metabolic process 9/502 319/18722 0.485893171150429 0.59605988059981 SPP1/LGMN/APOE/NPC2/ABCA1/ASAH1/EGR1/LIPA/TSPO 9 GO:0006814 sodium ion transport 7/502 245/18722 0.486133478221583 0.596196572177371 SCN9A/SLC9A9/ATP1B1/SLC8A1/SGK1/FXYD5/SLC4A7 7 GO:0060997 dendritic spine morphogenesis 2/502 61/18722 0.489570660819658 0.598536345144647 ACTR2/ADAM10 2 GO:0090342 regulation of cell aging 2/502 61/18722 0.489570660819658 0.598536345144647 B2M/NAMPT 2 GO:0007274 neuromuscular synaptic transmission 1/502 25/18722 0.493346105498604 0.598536345144647 FCHSD2 1 GO:0010560 positive regulation of glycoprotein biosynthetic process 1/502 25/18722 0.493346105498604 0.598536345144647 IGF1 1 GO:0010954 positive regulation of protein processing 1/502 25/18722 0.493346105498604 0.598536345144647 GSN 1 GO:0010996 response to auditory stimulus 1/502 25/18722 0.493346105498604 0.598536345144647 SLC1A3 1 GO:0015012 heparan sulfate proteoglycan biosynthetic process 1/502 25/18722 0.493346105498604 0.598536345144647 DSE 1 GO:0015874 norepinephrine transport 1/502 25/18722 0.493346105498604 0.598536345144647 ACTB 1 GO:0032400 melanosome localization 1/502 25/18722 0.493346105498604 0.598536345144647 MYO5A 1 GO:0032878 regulation of establishment or maintenance of cell polarity 1/502 25/18722 0.493346105498604 0.598536345144647 GSN 1 GO:0033119 negative regulation of RNA splicing 1/502 25/18722 0.493346105498604 0.598536345144647 TMBIM6 1 GO:0033233 regulation of protein sumoylation 1/502 25/18722 0.493346105498604 0.598536345144647 EGR1 1 GO:0036315 cellular response to sterol 1/502 25/18722 0.493346105498604 0.598536345144647 ABCA1 1 GO:0042730 fibrinolysis 1/502 25/18722 0.493346105498604 0.598536345144647 SERPING1 1 GO:0042832 defense response to protozoan 1/502 25/18722 0.493346105498604 0.598536345144647 CLEC7A 1 GO:0044550 secondary metabolite biosynthetic process 1/502 25/18722 0.493346105498604 0.598536345144647 ZEB2 1 GO:0045109 intermediate filament organization 1/502 25/18722 0.493346105498604 0.598536345144647 VIM 1 GO:0045822 negative regulation of heart contraction 1/502 25/18722 0.493346105498604 0.598536345144647 JAK2 1 GO:0046039 GTP metabolic process 1/502 25/18722 0.493346105498604 0.598536345144647 GIMAP7 1 GO:0046339 diacylglycerol metabolic process 1/502 25/18722 0.493346105498604 0.598536345144647 PLA2G15 1 GO:0046949 fatty-acyl-CoA biosynthetic process 1/502 25/18722 0.493346105498604 0.598536345144647 PPT1 1 GO:0048596 embryonic camera-type eye morphogenesis 1/502 25/18722 0.493346105498604 0.598536345144647 CITED2 1 GO:0050951 sensory perception of temperature stimulus 1/502 25/18722 0.493346105498604 0.598536345144647 ARRB2 1 GO:0051291 protein heterooligomerization 1/502 25/18722 0.493346105498604 0.598536345144647 MAT2A 1 GO:0060706 cell differentiation involved in embryonic placenta development 1/502 25/18722 0.493346105498604 0.598536345144647 STK4 1 GO:0060740 prostate gland epithelium morphogenesis 1/502 25/18722 0.493346105498604 0.598536345144647 FEM1B 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/502 25/18722 0.493346105498604 0.598536345144647 MSN 1 GO:0062009 secondary palate development 1/502 25/18722 0.493346105498604 0.598536345144647 TGFBR2 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/502 25/18722 0.493346105498604 0.598536345144647 ARRB2 1 GO:0071459 protein localization to chromosome, centromeric region 1/502 25/18722 0.493346105498604 0.598536345144647 RB1 1 GO:0072202 cell differentiation involved in metanephros development 1/502 25/18722 0.493346105498604 0.598536345144647 STAT1 1 GO:0072207 metanephric epithelium development 1/502 25/18722 0.493346105498604 0.598536345144647 STAT1 1 GO:0086013 membrane repolarization during cardiac muscle cell action potential 1/502 25/18722 0.493346105498604 0.598536345144647 ATP1B1 1 GO:0090169 regulation of spindle assembly 1/502 25/18722 0.493346105498604 0.598536345144647 HSPA1A 1 GO:0090382 phagosome maturation 1/502 25/18722 0.493346105498604 0.598536345144647 MCOLN1 1 GO:1900078 positive regulation of cellular response to insulin stimulus 1/502 25/18722 0.493346105498604 0.598536345144647 GNAI2 1 GO:1902993 positive regulation of amyloid precursor protein catabolic process 1/502 25/18722 0.493346105498604 0.598536345144647 LYN 1 GO:1903959 regulation of anion transmembrane transport 1/502 25/18722 0.493346105498604 0.598536345144647 PRNP 1 GO:1904385 cellular response to angiotensin 1/502 25/18722 0.493346105498604 0.598536345144647 CYBA 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/502 25/18722 0.493346105498604 0.598536345144647 STAT3 1 GO:2000311 regulation of AMPA receptor activity 1/502 25/18722 0.493346105498604 0.598536345144647 MEF2C 1 GO:0006163 purine nucleotide metabolic process 11/502 396/18722 0.495633519696348 0.600996241707813 IGF1/TMSB4X/SAMHD1/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 11 GO:0019693 ribose phosphate metabolic process 11/502 396/18722 0.495633519696348 0.600996241707813 IGF1/TMSB4X/PDK4/PYGL/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 11 GO:0043010 camera-type eye development 9/502 322/18722 0.497131377433704 0.60265454717199 MAF/SPRED1/NRP1/TGFBR2/VIM/KLF4/HIF1A/CITED2/SKIL 9 GO:0007631 feeding behavior 3/502 99/18722 0.49779316749793 0.603149200123948 FOS/GLS/STAT3 3 GO:0009311 oligosaccharide metabolic process 2/502 62/18722 0.498172917410944 0.603149200123948 ST8SIA4/GAA 2 GO:0046847 filopodium assembly 2/502 62/18722 0.498172917410944 0.603149200123948 NRP1/PIK3R1 2 GO:0060113 inner ear receptor cell differentiation 2/502 62/18722 0.498172917410944 0.603149200123948 RBPJ/SLC4A7 2 GO:0042391 regulation of membrane potential 12/502 434/18722 0.498191330236404 0.603149200123948 MEF2C/SCN9A/ATP1B1/CD36/ARRB2/SLC8A1/SOD2/UCP2/TSPO/CHCHD10/JUN/BNIP3L 12 GO:0021537 telencephalon development 7/502 248/18722 0.498933658130734 0.603889875068753 SLC8A1/BTG2/HIF1A/RTN4/TACC1/ATF5/LRP1 7 GO:0046474 glycerophospholipid biosynthetic process 6/502 211/18722 0.50000543970404 0.605028816131543 ATM/PLSCR1/ETNK1/CEPT1/PIK3R1/EFR3A 6 GO:0007586 digestion 4/502 137/18722 0.502712824554753 0.607986804285043 CD36/TLR4/TYMP/SGK1 4 GO:0055123 digestive system development 4/502 137/18722 0.502712824554753 0.607986804285043 PDGFC/RB1/TGFBR2/HIF1A 4 GO:0006664 glycolipid metabolic process 3/502 100/18722 0.504509967668983 0.608339245197439 ST8SIA4/FUCA1/HEXA 3 GO:0006910 phagocytosis, recognition 3/502 100/18722 0.504509967668983 0.608339245197439 CD36/CLEC7A/COLEC12 3 GO:0006457 protein folding 6/502 212/18722 0.50460349330723 0.608339245197439 CD74/B2M/FKBP5/GRN/HSPA1A/RANBP2 6 GO:0001756 somitogenesis 2/502 63/18722 0.506681916006397 0.608339245197439 RBPJ/ABI1 2 GO:0001556 oocyte maturation 1/502 26/18722 0.506949370997866 0.608339245197439 FOXO3 1 GO:0001562 response to protozoan 1/502 26/18722 0.506949370997866 0.608339245197439 CLEC7A 1 GO:0001963 synaptic transmission, dopaminergic 1/502 26/18722 0.506949370997866 0.608339245197439 ARRB2 1 GO:0003416 endochondral bone growth 1/502 26/18722 0.506949370997866 0.608339245197439 TGFBR2 1 GO:0006517 protein deglycosylation 1/502 26/18722 0.506949370997866 0.608339245197439 MAN1A1 1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1/502 26/18722 0.506949370997866 0.608339245197439 TRAM1 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/502 26/18722 0.506949370997866 0.608339245197439 GNAI2 1 GO:0014829 vascular associated smooth muscle contraction 1/502 26/18722 0.506949370997866 0.608339245197439 SLC8A1 1 GO:0021952 central nervous system projection neuron axonogenesis 1/502 26/18722 0.506949370997866 0.608339245197439 NR4A2 1 GO:0033522 histone H2A ubiquitination 1/502 26/18722 0.506949370997866 0.608339245197439 DTX3L 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/502 26/18722 0.506949370997866 0.608339245197439 HIF1A 1 GO:0045026 plasma membrane fusion 1/502 26/18722 0.506949370997866 0.608339245197439 FOLR2 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/502 26/18722 0.506949370997866 0.608339245197439 RUNX1 1 GO:0047497 mitochondrion transport along microtubule 1/502 26/18722 0.506949370997866 0.608339245197439 HIF1A 1 GO:0048843 negative regulation of axon extension involved in axon guidance 1/502 26/18722 0.506949370997866 0.608339245197439 NRP1 1 GO:0051350 negative regulation of lyase activity 1/502 26/18722 0.506949370997866 0.608339245197439 GNAI2 1 GO:0051875 pigment granule localization 1/502 26/18722 0.506949370997866 0.608339245197439 MYO5A 1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 1/502 26/18722 0.506949370997866 0.608339245197439 CALM2 1 GO:0060352 cell adhesion molecule production 1/502 26/18722 0.506949370997866 0.608339245197439 COLEC12 1 GO:0060669 embryonic placenta morphogenesis 1/502 26/18722 0.506949370997866 0.608339245197439 ZFP36L1 1 GO:0070977 bone maturation 1/502 26/18722 0.506949370997866 0.608339245197439 IGF1 1 GO:0072273 metanephric nephron morphogenesis 1/502 26/18722 0.506949370997866 0.608339245197439 STAT1 1 GO:1901071 glucosamine-containing compound metabolic process 1/502 26/18722 0.506949370997866 0.608339245197439 GNPDA1 1 GO:1903523 negative regulation of blood circulation 1/502 26/18722 0.506949370997866 0.608339245197439 JAK2 1 GO:1904353 regulation of telomere capping 1/502 26/18722 0.506949370997866 0.608339245197439 ATM 1 GO:1904861 excitatory synapse assembly 1/502 26/18722 0.506949370997866 0.608339245197439 PLXNB2 1 GO:0000724 double-strand break repair via homologous recombination 4/502 138/18722 0.508412135038759 0.609936342502411 SAMHD1/ACTR2/WAS/NABP1 4 GO:1903509 liposaccharide metabolic process 3/502 101/18722 0.511180187087972 0.61309814505288 ST8SIA4/FUCA1/HEXA 3 GO:0045017 glycerolipid biosynthetic process 7/502 252/18722 0.515839980022594 0.618526632344355 ATM/PLA2G15/PLSCR1/ETNK1/CEPT1/PIK3R1/EFR3A 7 GO:0030324 lung development 5/502 177/18722 0.516360992113629 0.618609302012502 CTSZ/RBPJ/KLF2/LIPA/TGFBR2 5 GO:0051302 regulation of cell division 5/502 177/18722 0.516360992113629 0.618609302012502 PDGFC/TXNIP/TGFB1/EVI2B/CALM2 5 GO:0034308 primary alcohol metabolic process 3/502 102/18722 0.517802800823958 0.618609302012502 IGF1/ALDH1A1/DHRS3 3 GO:0000725 recombinational repair 4/502 140/18722 0.519721593252361 0.618609302012502 SAMHD1/ACTR2/WAS/NABP1 4 GO:0007292 female gamete generation 4/502 140/18722 0.519721593252361 0.618609302012502 IGF1/FOXO3/NRIP1/PRKAR1A 4 GO:0001958 endochondral ossification 1/502 27/18722 0.520188107399186 0.618609302012502 MEF2C 1 GO:0002825 regulation of T-helper 1 type immune response 1/502 27/18722 0.520188107399186 0.618609302012502 HAVCR2 1 GO:0003171 atrioventricular valve development 1/502 27/18722 0.520188107399186 0.618609302012502 TGFBR2 1 GO:0007026 negative regulation of microtubule depolymerization 1/502 27/18722 0.520188107399186 0.618609302012502 TAOK1 1 GO:0007628 adult walking behavior 1/502 27/18722 0.520188107399186 0.618609302012502 ARRB2 1 GO:0009651 response to salt stress 1/502 27/18722 0.520188107399186 0.618609302012502 ZFP36L1 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/502 27/18722 0.520188107399186 0.618609302012502 ITM2B 1 GO:0010586 miRNA metabolic process 1/502 27/18722 0.520188107399186 0.618609302012502 DDX17 1 GO:0010894 negative regulation of steroid biosynthetic process 1/502 27/18722 0.520188107399186 0.618609302012502 APOE 1 GO:0015813 L-glutamate transmembrane transport 1/502 27/18722 0.520188107399186 0.618609302012502 SLC1A3 1 GO:0018126 protein hydroxylation 1/502 27/18722 0.520188107399186 0.618609302012502 P4HA1 1 GO:0018904 ether metabolic process 1/502 27/18722 0.520188107399186 0.618609302012502 ALOX5 1 GO:0032781 positive regulation of ATPase activity 1/502 27/18722 0.520188107399186 0.618609302012502 ATP1B1 1 GO:0034698 response to gonadotropin 1/502 27/18722 0.520188107399186 0.618609302012502 ICAM1 1 GO:0035235 ionotropic glutamate receptor signaling pathway 1/502 27/18722 0.520188107399186 0.618609302012502 CPEB4 1 GO:0036075 replacement ossification 1/502 27/18722 0.520188107399186 0.618609302012502 MEF2C 1 GO:0042403 thyroid hormone metabolic process 1/502 27/18722 0.520188107399186 0.618609302012502 CTSB 1 GO:0048520 positive regulation of behavior 1/502 27/18722 0.520188107399186 0.618609302012502 MEF2C 1 GO:0048873 homeostasis of number of cells within a tissue 1/502 27/18722 0.520188107399186 0.618609302012502 LIPA 1 GO:0060512 prostate gland morphogenesis 1/502 27/18722 0.520188107399186 0.618609302012502 FEM1B 1 GO:0070861 regulation of protein exit from endoplasmic reticulum 1/502 27/18722 0.520188107399186 0.618609302012502 CD81 1 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 1/502 27/18722 0.520188107399186 0.618609302012502 CD63 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/502 27/18722 0.520188107399186 0.618609302012502 ATP1B1 1 GO:1903205 regulation of hydrogen peroxide-induced cell death 1/502 27/18722 0.520188107399186 0.618609302012502 FOXO3 1 GO:1903319 positive regulation of protein maturation 1/502 27/18722 0.520188107399186 0.618609302012502 GSN 1 GO:1903421 regulation of synaptic vesicle recycling 1/502 27/18722 0.520188107399186 0.618609302012502 CYFIP1 1 GO:1903859 regulation of dendrite extension 1/502 27/18722 0.520188107399186 0.618609302012502 ITSN2 1 GO:0006487 protein N-linked glycosylation 2/502 65/18722 0.52341550583707 0.621807942989801 MGAT4A/MGAT1 2 GO:0045682 regulation of epidermis development 2/502 65/18722 0.52341550583707 0.621807942989801 ZFP36L1/ZFP36 2 GO:0046503 glycerolipid catabolic process 2/502 65/18722 0.52341550583707 0.621807942989801 ENPP2/PLA2G15 2 GO:0070936 protein K48-linked ubiquitination 2/502 65/18722 0.52341550583707 0.621807942989801 IFI27/DTX3L 2 GO:0008584 male gonad development 4/502 141/18722 0.52533025247866 0.623762255638162 ICAM1/NUPR1/NCOA4/CITED2 4 GO:0048284 organelle fusion 4/502 141/18722 0.52533025247866 0.623762255638162 STX7/SAMD9/STX12/RAB8B 4 GO:0009150 purine ribonucleotide metabolic process 10/502 368/18722 0.527932519535631 0.626691258755922 IGF1/TMSB4X/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 10 GO:0015698 inorganic anion transport 5/502 180/18722 0.531284637875352 0.628118025577862 TTYH3/PRNP/TSPO/SLC1A3/SLC4A7 5 GO:0019229 regulation of vasoconstriction 2/502 66/18722 0.531638100615437 0.628118025577862 ICAM1/TBXAS1 2 GO:0046626 regulation of insulin receptor signaling pathway 2/502 66/18722 0.531638100615437 0.628118025577862 GNAI2/PIK3R1 2 GO:0000423 mitophagy 1/502 28/18722 0.533072064076672 0.628118025577862 VPS13C 1 GO:0001945 lymph vessel development 1/502 28/18722 0.533072064076672 0.628118025577862 SYK 1 GO:0003156 regulation of animal organ formation 1/502 28/18722 0.533072064076672 0.628118025577862 CITED2 1 GO:0006972 hyperosmotic response 1/502 28/18722 0.533072064076672 0.628118025577862 HNMT 1 GO:0007064 mitotic sister chromatid cohesion 1/502 28/18722 0.533072064076672 0.628118025577862 RB1 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/502 28/18722 0.533072064076672 0.628118025577862 LRP1 1 GO:0007271 synaptic transmission, cholinergic 1/502 28/18722 0.533072064076672 0.628118025577862 APOE 1 GO:0015740 C4-dicarboxylate transport 1/502 28/18722 0.533072064076672 0.628118025577862 SLC1A3 1 GO:0031440 regulation of mRNA 3'-end processing 1/502 28/18722 0.533072064076672 0.628118025577862 ZFP36L1 1 GO:0032438 melanosome organization 1/502 28/18722 0.533072064076672 0.628118025577862 ZEB2 1 GO:0032958 inositol phosphate biosynthetic process 1/502 28/18722 0.533072064076672 0.628118025577862 PLEK 1 GO:0042983 amyloid precursor protein biosynthetic process 1/502 28/18722 0.533072064076672 0.628118025577862 ITM2B 1 GO:0042984 regulation of amyloid precursor protein biosynthetic process 1/502 28/18722 0.533072064076672 0.628118025577862 ITM2B 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/502 28/18722 0.533072064076672 0.628118025577862 PARP14 1 GO:0051503 adenine nucleotide transport 1/502 28/18722 0.533072064076672 0.628118025577862 CR1 1 GO:0060259 regulation of feeding behavior 1/502 28/18722 0.533072064076672 0.628118025577862 STAT3 1 GO:0062125 regulation of mitochondrial gene expression 1/502 28/18722 0.533072064076672 0.628118025577862 CHCHD10 1 GO:0070076 histone lysine demethylation 1/502 28/18722 0.533072064076672 0.628118025577862 JMJD1C 1 GO:0071280 cellular response to copper ion 1/502 28/18722 0.533072064076672 0.628118025577862 PRNP 1 GO:0086011 membrane repolarization during action potential 1/502 28/18722 0.533072064076672 0.628118025577862 ATP1B1 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/502 28/18722 0.533072064076672 0.628118025577862 PYCARD 1 GO:0090344 negative regulation of cell aging 1/502 28/18722 0.533072064076672 0.628118025577862 NAMPT 1 GO:0090659 walking behavior 1/502 28/18722 0.533072064076672 0.628118025577862 ARRB2 1 GO:1903020 positive regulation of glycoprotein metabolic process 1/502 28/18722 0.533072064076672 0.628118025577862 IGF1 1 GO:1903672 positive regulation of sprouting angiogenesis 1/502 28/18722 0.533072064076672 0.628118025577862 KLF4 1 GO:1903779 regulation of cardiac conduction 1/502 28/18722 0.533072064076672 0.628118025577862 SLC8A1 1 GO:0030323 respiratory tube development 5/502 181/18722 0.53621348820362 0.631457132038451 CTSZ/RBPJ/KLF2/LIPA/TGFBR2 5 GO:0099504 synaptic vesicle cycle 5/502 181/18722 0.53621348820362 0.631457132038451 ITSN1/ACTB/ITSN2/CYFIP1/FCHO2 5 GO:0071805 potassium ion transmembrane transport 6/502 219/18722 0.536340531021096 0.631457132038451 SLC9A9/ATP1B1/PRNP/CD63/SLC1A3/CAB39 6 GO:0030010 establishment of cell polarity 4/502 143/18722 0.536451908541096 0.631457132038451 FRMD4B/CYTH1/MSN/GSN 4 GO:0001654 eye development 10/502 371/18722 0.538316726867283 0.633491014624282 MAF/SPRED1/NRP1/TGFBR2/VIM/KLF4/STAT3/HIF1A/CITED2/SKIL 10 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 2/502 67/18722 0.539763432480243 0.634870490377219 CCL2/CCR1 2 GO:0042490 mechanoreceptor differentiation 2/502 67/18722 0.539763432480243 0.634870490377219 RBPJ/SLC4A7 2 GO:0031503 protein-containing complex localization 6/502 220/18722 0.540804865137142 0.635773097558741 TYROBP/TNFAIP2/EPS15/ATM/STX7/ADAM10 6 GO:0045165 cell fate commitment 7/502 258/18722 0.540805693664861 0.635773097558741 MEF2C/RBPJ/NRP1/KLF4/MCL1/STAT3/ETS2 7 GO:0031644 regulation of nervous system process 4/502 144/18722 0.541963574535774 0.636972432876649 CCL3/CTSC/TNFRSF1B/TYMP 4 GO:0006766 vitamin metabolic process 3/502 106/18722 0.543798528582967 0.637211622756355 PLTP/LGMN/SLC2A3 3 GO:0002360 T cell lineage commitment 1/502 29/18722 0.54561073016384 0.637211622756355 STAT3 1 GO:0003209 cardiac atrium morphogenesis 1/502 29/18722 0.54561073016384 0.637211622756355 ENG 1 GO:0005979 regulation of glycogen biosynthetic process 1/502 29/18722 0.54561073016384 0.637211622756355 IGF1 1 GO:0006656 phosphatidylcholine biosynthetic process 1/502 29/18722 0.54561073016384 0.637211622756355 CEPT1 1 GO:0006688 glycosphingolipid biosynthetic process 1/502 29/18722 0.54561073016384 0.637211622756355 ST8SIA4 1 GO:0007143 female meiotic nuclear division 1/502 29/18722 0.54561073016384 0.637211622756355 PRKAR1A 1 GO:0010390 histone monoubiquitination 1/502 29/18722 0.54561073016384 0.637211622756355 DTX3L 1 GO:0010458 exit from mitosis 1/502 29/18722 0.54561073016384 0.637211622756355 EPS8 1 GO:0010962 regulation of glucan biosynthetic process 1/502 29/18722 0.54561073016384 0.637211622756355 IGF1 1 GO:0015701 bicarbonate transport 1/502 29/18722 0.54561073016384 0.637211622756355 SLC4A7 1 GO:0015868 purine ribonucleotide transport 1/502 29/18722 0.54561073016384 0.637211622756355 CR1 1 GO:0021772 olfactory bulb development 1/502 29/18722 0.54561073016384 0.637211622756355 ATF5 1 GO:0030970 retrograde protein transport, ER to cytosol 1/502 29/18722 0.54561073016384 0.637211622756355 HERPUD1 1 GO:0033028 myeloid cell apoptotic process 1/502 29/18722 0.54561073016384 0.637211622756355 MEF2C 1 GO:0034067 protein localization to Golgi apparatus 1/502 29/18722 0.54561073016384 0.637211622756355 VPS13C 1 GO:0048753 pigment granule organization 1/502 29/18722 0.54561073016384 0.637211622756355 ZEB2 1 GO:0051654 establishment of mitochondrion localization 1/502 29/18722 0.54561073016384 0.637211622756355 HIF1A 1 GO:0060441 epithelial tube branching involved in lung morphogenesis 1/502 29/18722 0.54561073016384 0.637211622756355 CTSZ 1 GO:0070198 protein localization to chromosome, telomeric region 1/502 29/18722 0.54561073016384 0.637211622756355 TPP1 1 GO:0071549 cellular response to dexamethasone stimulus 1/502 29/18722 0.54561073016384 0.637211622756355 ICAM1 1 GO:0098868 bone growth 1/502 29/18722 0.54561073016384 0.637211622756355 TGFBR2 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/502 29/18722 0.54561073016384 0.637211622756355 CAB39 1 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 1/502 29/18722 0.54561073016384 0.637211622756355 CD63 1 GO:1903513 endoplasmic reticulum to cytosol transport 1/502 29/18722 0.54561073016384 0.637211622756355 HERPUD1 1 GO:0031640 killing of cells of other organism 2/502 68/18722 0.547790796823519 0.639112289055636 SYK/CLEC7A 2 GO:1901016 regulation of potassium ion transmembrane transporter activity 2/502 68/18722 0.547790796823519 0.639112289055636 ATP1B1/CAB39 2 GO:1901607 alpha-amino acid biosynthetic process 2/502 68/18722 0.547790796823519 0.639112289055636 GLUL/GLS 2 GO:1902305 regulation of sodium ion transmembrane transport 2/502 68/18722 0.547790796823519 0.639112289055636 ATP1B1/FXYD5 2 GO:0006275 regulation of DNA replication 3/502 107/18722 0.550169552139734 0.641725755975393 CCDC88A/ATG7/JUN 3 GO:0019226 transmission of nerve impulse 2/502 69/18722 0.555719596469206 0.647701937178051 SCN9A/TYMP 2 GO:0045665 negative regulation of neuron differentiation 2/502 69/18722 0.555719596469206 0.647701937178051 B2M/FOXO3 2 GO:0008209 androgen metabolic process 1/502 30/18722 0.557813341486674 0.647701937178051 SPP1 1 GO:0010669 epithelial structure maintenance 1/502 30/18722 0.557813341486674 0.647701937178051 TLR4 1 GO:0015721 bile acid and bile salt transport 1/502 30/18722 0.557813341486674 0.647701937178051 SLCO2B1 1 GO:0015865 purine nucleotide transport 1/502 30/18722 0.557813341486674 0.647701937178051 CR1 1 GO:0030204 chondroitin sulfate metabolic process 1/502 30/18722 0.557813341486674 0.647701937178051 DSE 1 GO:0031571 mitotic G1 DNA damage checkpoint signaling 1/502 30/18722 0.557813341486674 0.647701937178051 ATM 1 GO:0034508 centromere complex assembly 1/502 30/18722 0.557813341486674 0.647701937178051 RB1 1 GO:0034694 response to prostaglandin 1/502 30/18722 0.557813341486674 0.647701937178051 PTGER4 1 GO:0044030 regulation of DNA methylation 1/502 30/18722 0.557813341486674 0.647701937178051 SPI1 1 GO:0045939 negative regulation of steroid metabolic process 1/502 30/18722 0.557813341486674 0.647701937178051 APOE 1 GO:0045940 positive regulation of steroid metabolic process 1/502 30/18722 0.557813341486674 0.647701937178051 APOE 1 GO:0048799 animal organ maturation 1/502 30/18722 0.557813341486674 0.647701937178051 IGF1 1 GO:0060218 hematopoietic stem cell differentiation 1/502 30/18722 0.557813341486674 0.647701937178051 N4BP2L2 1 GO:0060351 cartilage development involved in endochondral bone morphogenesis 1/502 30/18722 0.557813341486674 0.647701937178051 TGFBR2 1 GO:0060603 mammary gland duct morphogenesis 1/502 30/18722 0.557813341486674 0.647701937178051 CSF1R 1 GO:0070498 interleukin-1-mediated signaling pathway 1/502 30/18722 0.557813341486674 0.647701937178051 EGR1 1 GO:0043588 skin development 7/502 263/18722 0.56120127918893 0.651472300508906 TXNIP/ZFP36L1/RBPJ/ZFP36/ADAM9/ASAH1/STK4 7 GO:0072521 purine-containing compound metabolic process 11/502 416/18722 0.561766087791218 0.651964355775758 IGF1/TMSB4X/SAMHD1/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 11 GO:0070830 bicellular tight junction assembly 2/502 70/18722 0.563549336439911 0.653843749586899 MTDH/PECAM1 2 GO:0050905 neuromuscular process 4/502 148/18722 0.563668152475693 0.653843749586899 TPP1/NR4A1/GAA/SLC1A3 4 GO:0009063 cellular amino acid catabolic process 3/502 110/18722 0.568963849463751 0.657038342734224 HNMT/GLUL/GLS 3 GO:1905039 carboxylic acid transmembrane transport 4/502 149/18722 0.56900595129116 0.657038342734224 FOLR2/CD36/EMB/SLC1A3 4 GO:0002063 chondrocyte development 1/502 31/18722 0.569688887312359 0.657038342734224 TGFBR2 1 GO:0002323 natural killer cell activation involved in immune response 1/502 31/18722 0.569688887312359 0.657038342734224 LAMP1 1 GO:0006613 cotranslational protein targeting to membrane 1/502 31/18722 0.569688887312359 0.657038342734224 TRAM1 1 GO:0007190 activation of adenylate cyclase activity 1/502 31/18722 0.569688887312359 0.657038342734224 TMIGD3 1 GO:0008045 motor neuron axon guidance 1/502 31/18722 0.569688887312359 0.657038342734224 NRP1 1 GO:0016577 histone demethylation 1/502 31/18722 0.569688887312359 0.657038342734224 JMJD1C 1 GO:0021988 olfactory lobe development 1/502 31/18722 0.569688887312359 0.657038342734224 ATF5 1 GO:0030201 heparan sulfate proteoglycan metabolic process 1/502 31/18722 0.569688887312359 0.657038342734224 DSE 1 GO:0031114 regulation of microtubule depolymerization 1/502 31/18722 0.569688887312359 0.657038342734224 TAOK1 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/502 31/18722 0.569688887312359 0.657038342734224 MGAT1 1 GO:0036474 cell death in response to hydrogen peroxide 1/502 31/18722 0.569688887312359 0.657038342734224 FOXO3 1 GO:0042133 neurotransmitter metabolic process 1/502 31/18722 0.569688887312359 0.657038342734224 HNMT 1 GO:0043171 peptide catabolic process 1/502 31/18722 0.569688887312359 0.657038342734224 TPP1 1 GO:0044819 mitotic G1/S transition checkpoint signaling 1/502 31/18722 0.569688887312359 0.657038342734224 ATM 1 GO:0050482 arachidonic acid secretion 1/502 31/18722 0.569688887312359 0.657038342734224 SYK 1 GO:0051569 regulation of histone H3-K4 methylation 1/502 31/18722 0.569688887312359 0.657038342734224 KMT2E 1 GO:0055075 potassium ion homeostasis 1/502 31/18722 0.569688887312359 0.657038342734224 ATP1B1 1 GO:0070528 protein kinase C signaling 1/502 31/18722 0.569688887312359 0.657038342734224 PLEK 1 GO:0071711 basement membrane organization 1/502 31/18722 0.569688887312359 0.657038342734224 CTSS 1 GO:0090183 regulation of kidney development 1/502 31/18722 0.569688887312359 0.657038342734224 STAT1 1 GO:1903963 arachidonate transport 1/502 31/18722 0.569688887312359 0.657038342734224 SYK 1 GO:0048839 inner ear development 5/502 188/18722 0.570024401485769 0.657261436010261 MAF/MAFB/RBPJ/SLC4A7/ADAM10 5 GO:0007411 axon guidance 6/502 227/18722 0.571511855717471 0.658812321093701 PLXND1/NRP1/EMB/CYFIP1/LRP1/PLXNB2 6 GO:1903825 organic acid transmembrane transport 4/502 150/18722 0.574307367002451 0.661869925200134 FOLR2/CD36/EMB/SLC1A3 4 GO:0097485 neuron projection guidance 6/502 228/18722 0.575816569459425 0.663443947775667 PLXND1/NRP1/EMB/CYFIP1/LRP1/PLXNB2 6 GO:0001707 mesoderm formation 2/502 72/18722 0.57891013845088 0.666676201263074 KLF4/PRKAR1A 2 GO:0035567 non-canonical Wnt signaling pathway 2/502 72/18722 0.57891013845088 0.666676201263074 DAB2/RNF213 2 GO:0003338 metanephros morphogenesis 1/502 32/18722 0.581246116918543 0.667041562109943 STAT1 1 GO:0008156 negative regulation of DNA replication 1/502 32/18722 0.581246116918543 0.667041562109943 ATG7 1 GO:0019228 neuronal action potential 1/502 32/18722 0.581246116918543 0.667041562109943 SCN9A 1 GO:0021799 cerebral cortex radially oriented cell migration 1/502 32/18722 0.581246116918543 0.667041562109943 RTN4 1 GO:0030431 sleep 1/502 32/18722 0.581246116918543 0.667041562109943 FOS 1 GO:0033687 osteoblast proliferation 1/502 32/18722 0.581246116918543 0.667041562109943 JUNB 1 GO:0042744 hydrogen peroxide catabolic process 1/502 32/18722 0.581246116918543 0.667041562109943 GPX1 1 GO:0048841 regulation of axon extension involved in axon guidance 1/502 32/18722 0.581246116918543 0.667041562109943 NRP1 1 GO:0051642 centrosome localization 1/502 32/18722 0.581246116918543 0.667041562109943 RANBP2 1 GO:0060323 head morphogenesis 1/502 32/18722 0.581246116918543 0.667041562109943 ATP6AP2 1 GO:0072337 modified amino acid transport 1/502 32/18722 0.581246116918543 0.667041562109943 FOLR2 1 GO:0090140 regulation of mitochondrial fission 1/502 32/18722 0.581246116918543 0.667041562109943 STAT2 1 GO:1901889 negative regulation of cell junction assembly 1/502 32/18722 0.581246116918543 0.667041562109943 LRP1 1 GO:2000191 regulation of fatty acid transport 1/502 32/18722 0.581246116918543 0.667041562109943 SYK 1 GO:0016125 sterol metabolic process 4/502 152/18722 0.584799148245028 0.670786228559757 APOE/NPC2/ABCA1/LIPA 4 GO:0090501 RNA phosphodiester bond hydrolysis 4/502 152/18722 0.584799148245028 0.670786228559757 RNASE1/RNASE6/RNASET2/SAMHD1 4 GO:0009259 ribonucleotide metabolic process 10/502 385/18722 0.585614057773141 0.671554445031867 IGF1/TMSB4X/PDK4/PPT1/TGFB1/GIMAP7/NUPR1/STAT3/ADCY7/HIF1A 10 GO:0009166 nucleotide catabolic process 2/502 73/18722 0.586440677222878 0.672002618982669 SAMHD1/TYMP 2 GO:0061035 regulation of cartilage development 2/502 73/18722 0.586440677222878 0.672002618982669 MAF/TRPS1 2 GO:0099518 vesicle cytoskeletal trafficking 2/502 73/18722 0.586440677222878 0.672002618982669 MYO5A/MYO1F 2 GO:0001881 receptor recycling 1/502 33/18722 0.592493545987933 0.675591605555873 EPS15 1 GO:0006482 protein demethylation 1/502 33/18722 0.592493545987933 0.675591605555873 JMJD1C 1 GO:0008214 protein dealkylation 1/502 33/18722 0.592493545987933 0.675591605555873 JMJD1C 1 GO:0010165 response to X-ray 1/502 33/18722 0.592493545987933 0.675591605555873 ATM 1 GO:0018345 protein palmitoylation 1/502 33/18722 0.592493545987933 0.675591605555873 GLUL 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/502 33/18722 0.592493545987933 0.675591605555873 HIF1A 1 GO:0031116 positive regulation of microtubule polymerization 1/502 33/18722 0.592493545987933 0.675591605555873 HSPA1A 1 GO:0033198 response to ATP 1/502 33/18722 0.592493545987933 0.675591605555873 SLC8A1 1 GO:0040020 regulation of meiotic nuclear division 1/502 33/18722 0.592493545987933 0.675591605555873 PRKAR1A 1 GO:0046320 regulation of fatty acid oxidation 1/502 33/18722 0.592493545987933 0.675591605555873 PDK4 1 GO:0048048 embryonic eye morphogenesis 1/502 33/18722 0.592493545987933 0.675591605555873 CITED2 1 GO:0048333 mesodermal cell differentiation 1/502 33/18722 0.592493545987933 0.675591605555873 KLF4 1 GO:0048730 epidermis morphogenesis 1/502 33/18722 0.592493545987933 0.675591605555873 KLF4 1 GO:0050901 leukocyte tethering or rolling 1/502 33/18722 0.592493545987933 0.675591605555873 SELPLG 1 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 1/502 33/18722 0.592493545987933 0.675591605555873 ATF7IP 1 GO:0061842 microtubule organizing center localization 1/502 33/18722 0.592493545987933 0.675591605555873 RANBP2 1 GO:1900181 negative regulation of protein localization to nucleus 1/502 33/18722 0.592493545987933 0.675591605555873 CD36 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/502 33/18722 0.592493545987933 0.675591605555873 CAB39 1 GO:1902275 regulation of chromatin organization 1/502 33/18722 0.592493545987933 0.675591605555873 ATF7IP 1 GO:1902692 regulation of neuroblast proliferation 1/502 33/18722 0.592493545987933 0.675591605555873 HIF1A 1 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 2/502 74/18722 0.593871100671728 0.676495373481264 DAB2/DDX5 2 GO:0048332 mesoderm morphogenesis 2/502 74/18722 0.593871100671728 0.676495373481264 KLF4/PRKAR1A 2 GO:0120192 tight junction assembly 2/502 74/18722 0.593871100671728 0.676495373481264 MTDH/PECAM1 2 GO:1901568 fatty acid derivative metabolic process 2/502 74/18722 0.593871100671728 0.676495373481264 ALOX5/PPT1 2 GO:0007605 sensory perception of sound 4/502 154/18722 0.59513992321415 0.677773826880517 ICAM1/GPX1/SLC1A3/CCDC50 4 GO:1901989 positive regulation of cell cycle phase transition 3/502 115/18722 0.599189635531459 0.682217881852948 AIF1/RB1/KMT2E 3 GO:0046434 organophosphate catabolic process 4/502 155/18722 0.600252664914413 0.683260046233778 ENPP2/SAMHD1/TYMP/PLA2G15 4 GO:0046942 carboxylic acid transport 7/502 273/18722 0.600715315399824 0.683618462248361 FOLR2/SLCO2B1/CD36/PSAP/SYK/EMB/SLC1A3 7 GO:0045913 positive regulation of carbohydrate metabolic process 2/502 75/18722 0.601201353158668 0.68383512655815 IGF1/HIF1A 2 GO:0061333 renal tubule morphogenesis 2/502 75/18722 0.601201353158668 0.68383512655815 MEF2C/MTSS1 2 GO:0009112 nucleobase metabolic process 1/502 34/18722 0.603439462832818 0.684193861535445 TYMP 1 GO:0016242 negative regulation of macroautophagy 1/502 34/18722 0.603439462832818 0.684193861535445 NUPR1 1 GO:0032212 positive regulation of telomere maintenance via telomerase 1/502 34/18722 0.603439462832818 0.684193861535445 ATM 1 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1/502 34/18722 0.603439462832818 0.684193861535445 IFIH1 1 GO:0044319 wound healing, spreading of cells 1/502 34/18722 0.603439462832818 0.684193861535445 CD44 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/502 34/18722 0.603439462832818 0.684193861535445 SDCBP 1 GO:0048536 spleen development 1/502 34/18722 0.603439462832818 0.684193861535445 CITED2 1 GO:0048741 skeletal muscle fiber development 1/502 34/18722 0.603439462832818 0.684193861535445 GPX1 1 GO:0048854 brain morphogenesis 1/502 34/18722 0.603439462832818 0.684193861535445 FOXO3 1 GO:0051973 positive regulation of telomerase activity 1/502 34/18722 0.603439462832818 0.684193861535445 KLF4 1 GO:0070050 neuron cellular homeostasis 1/502 34/18722 0.603439462832818 0.684193861535445 TAOK1 1 GO:0090505 epiboly involved in wound healing 1/502 34/18722 0.603439462832818 0.684193861535445 CD44 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/502 34/18722 0.603439462832818 0.684193861535445 PARP14 1 GO:0008286 insulin receptor signaling pathway 3/502 116/18722 0.605065706597968 0.685869629679539 PDK4/GNAI2/PIK3R1 3 GO:0045685 regulation of glial cell differentiation 2/502 76/18722 0.608431453856727 0.689347025604021 TNFRSF1B/TGFB1 2 GO:0086001 cardiac muscle cell action potential 2/502 76/18722 0.608431453856727 0.689347025604021 ATP1B1/SLC8A1 2 GO:0046395 carboxylic acid catabolic process 6/502 236/18722 0.609454192982368 0.690167710339397 HNMT/GLUL/PLA2G15/GLS/NPL/GNPDA1 6 GO:0090068 positive regulation of cell cycle process 6/502 236/18722 0.609454192982368 0.690167710339397 IGF1/CD28/AIF1/RB1/PLSCR1/KMT2E 6 GO:0006084 acetyl-CoA metabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 PDK4 1 GO:0006739 NADP metabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 ME2 1 GO:0007020 microtubule nucleation 1/502 35/18722 0.614091934454068 0.691862953917321 HSPA1A 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/502 35/18722 0.614091934454068 0.691862953917321 RB1 1 GO:0010765 positive regulation of sodium ion transport 1/502 35/18722 0.614091934454068 0.691862953917321 ATP1B1 1 GO:0018149 peptide cross-linking 1/502 35/18722 0.614091934454068 0.691862953917321 F13A1 1 GO:0019068 virion assembly 1/502 35/18722 0.614091934454068 0.691862953917321 APOE 1 GO:0021955 central nervous system neuron axonogenesis 1/502 35/18722 0.614091934454068 0.691862953917321 NR4A2 1 GO:0031076 embryonic camera-type eye development 1/502 35/18722 0.614091934454068 0.691862953917321 CITED2 1 GO:0032205 negative regulation of telomere maintenance 1/502 35/18722 0.614091934454068 0.691862953917321 ATM 1 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 SDCBP 1 GO:0033280 response to vitamin D 1/502 35/18722 0.614091934454068 0.691862953917321 SPP1 1 GO:0044273 sulfur compound catabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 GNS 1 GO:0045454 cell redox homeostasis 1/502 35/18722 0.614091934454068 0.691862953917321 GPX1 1 GO:0046471 phosphatidylglycerol metabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 PLA2G15 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 DSE 1 GO:0070536 protein K63-linked deubiquitination 1/502 35/18722 0.614091934454068 0.691862953917321 OTUD1 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/502 35/18722 0.614091934454068 0.691862953917321 NRP1 1 GO:0090181 regulation of cholesterol metabolic process 1/502 35/18722 0.614091934454068 0.691862953917321 APOE 1 GO:0090504 epiboly 1/502 35/18722 0.614091934454068 0.691862953917321 CD44 1 GO:0097421 liver regeneration 1/502 35/18722 0.614091934454068 0.691862953917321 UCP2 1 GO:1901983 regulation of protein acetylation 2/502 77/18722 0.615561492794329 0.693349760327871 SPI1/TAOK1 2 GO:0048167 regulation of synaptic plasticity 5/502 198/18722 0.616013048186008 0.693689474417837 MEF2C/TYROBP/LGMN/APOE/PRNP 5 GO:0008380 RNA splicing 11/502 434/18722 0.618198548441644 0.695981135334885 CELF2/HSPA1A/QKI/MBNL1/SETX/IVNS1ABP/DDX17/DDX5/TMBIM6/SCAF11/PIK3R1 11 GO:0009064 glutamine family amino acid metabolic process 2/502 78/18722 0.622591627056553 0.700585956400782 GLUL/GLS 2 GO:0043297 apical junction assembly 2/502 78/18722 0.622591627056553 0.700585956400782 MTDH/PECAM1 2 GO:0003230 cardiac atrium development 1/502 36/18722 0.624458812438981 0.700641878812206 ENG 1 GO:0007031 peroxisome organization 1/502 36/18722 0.624458812438981 0.700641878812206 RAB8B 1 GO:0017004 cytochrome complex assembly 1/502 36/18722 0.624458812438981 0.700641878812206 CYBA 1 GO:0038179 neurotrophin signaling pathway 1/502 36/18722 0.624458812438981 0.700641878812206 CYFIP1 1 GO:0042755 eating behavior 1/502 36/18722 0.624458812438981 0.700641878812206 STAT3 1 GO:0044060 regulation of endocrine process 1/502 36/18722 0.624458812438981 0.700641878812206 RAB8B 1 GO:0045652 regulation of megakaryocyte differentiation 1/502 36/18722 0.624458812438981 0.700641878812206 MEF2C 1 GO:0045746 negative regulation of Notch signaling pathway 1/502 36/18722 0.624458812438981 0.700641878812206 EGFL7 1 GO:0070873 regulation of glycogen metabolic process 1/502 36/18722 0.624458812438981 0.700641878812206 IGF1 1 GO:0070897 transcription preinitiation complex assembly 1/502 36/18722 0.624458812438981 0.700641878812206 ATF7IP 1 GO:1901658 glycosyl compound catabolic process 1/502 36/18722 0.624458812438981 0.700641878812206 FUCA1 1 GO:1903539 protein localization to postsynaptic membrane 1/502 36/18722 0.624458812438981 0.700641878812206 ADAM10 1 GO:0043271 negative regulation of ion transport 4/502 160/18722 0.625225773022096 0.7013323050437 ICAM1/TMBIM6/CAB39/CALM2 4 GO:0016054 organic acid catabolic process 6/502 240/18722 0.625710920032514 0.701536286008339 HNMT/GLUL/PLA2G15/GLS/NPL/GNPDA1 6 GO:0032886 regulation of microtubule-based process 6/502 240/18722 0.625710920032514 0.701536286008339 HSPA1A/CLTC/LAMP1/ATF5/MACF1/TAOK1 6 GO:0007052 mitotic spindle organization 3/502 120/18722 0.627994342834125 0.703925812927226 HSPA1A/CLTC/TACC1 3 GO:0009952 anterior/posterior pattern specification 5/502 201/18722 0.62923403254223 0.705144533561133 RBPJ/BTG2/ATP6AP2/ETS2/ABI1 5 GO:0006029 proteoglycan metabolic process 2/502 79/18722 0.629522077138468 0.705296471020235 IGF1/DSE 2 GO:0006813 potassium ion transport 6/502 241/18722 0.629713911390824 0.705340569998535 SLC9A9/ATP1B1/PRNP/CD63/SLC1A3/CAB39 6 GO:0016051 carbohydrate biosynthetic process 5/502 202/18722 0.63357942006574 0.708695760317879 IGF1/PLEK/CLTC/TGFB1/RANBP2 5 GO:0006862 nucleotide transport 1/502 37/18722 0.63454773870226 0.708695760317879 CR1 1 GO:0031112 positive regulation of microtubule polymerization or depolymerization 1/502 37/18722 0.63454773870226 0.708695760317879 HSPA1A 1 GO:0031646 positive regulation of nervous system process 1/502 37/18722 0.63454773870226 0.708695760317879 TNFRSF1B 1 GO:0034260 negative regulation of GTPase activity 1/502 37/18722 0.63454773870226 0.708695760317879 ARRB2 1 GO:0043687 post-translational protein modification 1/502 37/18722 0.63454773870226 0.708695760317879 ATG7 1 GO:0048846 axon extension involved in axon guidance 1/502 37/18722 0.63454773870226 0.708695760317879 NRP1 1 GO:0050775 positive regulation of dendrite morphogenesis 1/502 37/18722 0.63454773870226 0.708695760317879 ACTR2 1 GO:0062237 protein localization to postsynapse 1/502 37/18722 0.63454773870226 0.708695760317879 ADAM10 1 GO:0072529 pyrimidine-containing compound catabolic process 1/502 37/18722 0.63454773870226 0.708695760317879 TYMP 1 GO:1902284 neuron projection extension involved in neuron projection guidance 1/502 37/18722 0.63454773870226 0.708695760317879 NRP1 1 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 1/502 37/18722 0.63454773870226 0.708695760317879 ATM 1 GO:0021953 central nervous system neuron differentiation 4/502 162/18722 0.63493376441403 0.708955731155999 B2M/NR4A2/NRP1/BTG2 4 GO:0120193 tight junction organization 2/502 80/18722 0.636353123445157 0.710369099675988 MTDH/PECAM1 2 GO:0060541 respiratory system development 5/502 203/18722 0.637893625212761 0.71191698678751 CTSZ/RBPJ/KLF2/LIPA/TGFBR2 5 GO:0019730 antimicrobial humoral response 3/502 122/18722 0.639109712103901 0.713102153447334 RNASE6/HLA-A/HLA-E 3 GO:0006520 cellular amino acid metabolic process 7/502 284/18722 0.641961766330249 0.716111678573362 ALDH1A1/HNMT/GLUL/BCAT1/PEPD/GLS/SLC1A3 7 GO:0008589 regulation of smoothened signaling pathway 2/502 81/18722 0.643085102933203 0.716203223178685 RB1/PRKACB 2 GO:2000243 positive regulation of reproductive process 2/502 81/18722 0.643085102933203 0.716203223178685 LHFPL2/CITED2 2 GO:2001021 negative regulation of response to DNA damage stimulus 2/502 81/18722 0.643085102933203 0.716203223178685 CD74/CD44 2 GO:0007007 inner mitochondrial membrane organization 1/502 38/18722 0.644366151074294 0.716203223178685 CHCHD10 1 GO:0010719 negative regulation of epithelial to mesenchymal transition 1/502 38/18722 0.644366151074294 0.716203223178685 SPRED1 1 GO:0032941 secretion by tissue 1/502 38/18722 0.644366151074294 0.716203223178685 CYBA 1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 1/502 38/18722 0.644366151074294 0.716203223178685 DAB2 1 GO:0035337 fatty-acyl-CoA metabolic process 1/502 38/18722 0.644366151074294 0.716203223178685 PPT1 1 GO:0046676 negative regulation of insulin secretion 1/502 38/18722 0.644366151074294 0.716203223178685 UCP2 1 GO:0048713 regulation of oligodendrocyte differentiation 1/502 38/18722 0.644366151074294 0.716203223178685 TNFRSF1B 1 GO:0051930 regulation of sensory perception of pain 1/502 38/18722 0.644366151074294 0.716203223178685 CCL3 1 GO:0071392 cellular response to estradiol stimulus 1/502 38/18722 0.644366151074294 0.716203223178685 NRIP1 1 GO:0071398 cellular response to fatty acid 1/502 38/18722 0.644366151074294 0.716203223178685 PDK4 1 GO:0099622 cardiac muscle cell membrane repolarization 1/502 38/18722 0.644366151074294 0.716203223178685 ATP1B1 1 GO:2000279 negative regulation of DNA biosynthetic process 1/502 38/18722 0.644366151074294 0.716203223178685 DUSP1 1 GO:0017148 negative regulation of translation 6/502 245/18722 0.645474940926468 0.717091036677676 ZFP36L1/ZFP36/CPEB4/BTG2/ZFP36L2/STAT3 6 GO:0098656 anion transmembrane transport 6/502 245/18722 0.645474940926468 0.717091036677676 FOLR2/SLC9A9/PRNP/EMB/SLC1A3/SLC4A7 6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 2/502 82/18722 0.649718405888587 0.721458796361162 RNASE1/RNASET2 2 GO:2001252 positive regulation of chromosome organization 2/502 82/18722 0.649718405888587 0.721458796361162 ATM/ATF7IP 2 GO:0140014 mitotic nuclear division 7/502 287/18722 0.652773158851737 0.724213522076818 IGF1/CD28/RB1/HSPA1A/ATM/DUSP1/EPS8 7 GO:0001941 postsynaptic membrane organization 1/502 39/18722 0.653921288740784 0.724213522076818 APOE 1 GO:0016233 telomere capping 1/502 39/18722 0.653921288740784 0.724213522076818 ATM 1 GO:0017158 regulation of calcium ion-dependent exocytosis 1/502 39/18722 0.653921288740784 0.724213522076818 GNAI2 1 GO:0031507 heterochromatin assembly 1/502 39/18722 0.653921288740784 0.724213522076818 ATF7IP 1 GO:0043267 negative regulation of potassium ion transport 1/502 39/18722 0.653921288740784 0.724213522076818 CAB39 1 GO:0045923 positive regulation of fatty acid metabolic process 1/502 39/18722 0.653921288740784 0.724213522076818 CD74 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/502 39/18722 0.653921288740784 0.724213522076818 XBP1 1 GO:0051931 regulation of sensory perception 1/502 39/18722 0.653921288740784 0.724213522076818 CCL3 1 GO:0090207 regulation of triglyceride metabolic process 1/502 39/18722 0.653921288740784 0.724213522076818 APOE 1 GO:2000785 regulation of autophagosome assembly 1/502 39/18722 0.653921288740784 0.724213522076818 NUPR1 1 GO:0070585 protein localization to mitochondrion 3/502 125/18722 0.655342682668427 0.725613989953121 ISG15/TSPO/BNIP3L 3 GO:0061053 somite development 2/502 83/18722 0.656253472836127 0.72627477639711 RBPJ/ABI1 2 GO:1901292 nucleoside phosphate catabolic process 2/502 83/18722 0.656253472836127 0.72627477639711 SAMHD1/TYMP 2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 4/502 167/18722 0.658483892781811 0.728568880174278 CD84/PECAM1/EMB/PLXNB2 4 GO:0006835 dicarboxylic acid transport 2/502 84/18722 0.662690791575748 0.731534724322661 FOLR2/SLC1A3 2 GO:0015844 monoamine transport 2/502 84/18722 0.662690791575748 0.731534724322661 SYK/ACTB 2 GO:0032508 DNA duplex unwinding 2/502 84/18722 0.662690791575748 0.731534724322661 CHD9/SETX 2 GO:0006730 one-carbon metabolic process 1/502 40/18722 0.663220197537665 0.731534724322661 MAT2A 1 GO:0009187 cyclic nucleotide metabolic process 1/502 40/18722 0.663220197537665 0.731534724322661 ADCY7 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization 1/502 40/18722 0.663220197537665 0.731534724322661 TAOK1 1 GO:0031297 replication fork processing 1/502 40/18722 0.663220197537665 0.731534724322661 SAMHD1 1 GO:0035329 hippo signaling 1/502 40/18722 0.663220197537665 0.731534724322661 STK4 1 GO:0045740 positive regulation of DNA replication 1/502 40/18722 0.663220197537665 0.731534724322661 JUN 1 GO:0045777 positive regulation of blood pressure 1/502 40/18722 0.663220197537665 0.731534724322661 CYBA 1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 1/502 40/18722 0.663220197537665 0.731534724322661 CALM2 1 GO:0070266 necroptotic process 1/502 40/18722 0.663220197537665 0.731534724322661 PYGL 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/502 40/18722 0.663220197537665 0.731534724322661 CALM2 1 GO:0035270 endocrine system development 3/502 127/18722 0.665870217789182 0.734282628722945 RBPJ/TSPO/CITED2 3 GO:0010498 proteasomal protein catabolic process 12/502 490/18722 0.666453573434338 0.734750769949296 APOE/DAB2/IFI27/MAN1A1/ARRB2/WWP1/HSPA1A/SDCBP/GPX1/NUPR1/FEM1B/HERPUD1 12 GO:0006937 regulation of muscle contraction 4/502 169/18722 0.667612331412958 0.735852905674611 ATP1B1/SLC8A1/NR4A1/CALM2 4 GO:0001656 metanephros development 2/502 85/18722 0.669030894341011 0.736539009334012 EGR1/STAT1 2 GO:0030433 ubiquitin-dependent ERAD pathway 2/502 85/18722 0.669030894341011 0.736539009334012 MAN1A1/HERPUD1 2 GO:0060021 roof of mouth development 2/502 85/18722 0.669030894341011 0.736539009334012 TGFBR2/DHRS3 2 GO:0072384 organelle transport along microtubule 2/502 85/18722 0.669030894341011 0.736539009334012 LAMP1/HIF1A 2 GO:0097194 execution phase of apoptosis 2/502 85/18722 0.669030894341011 0.736539009334012 PLSCR1/TAOK1 2 GO:0006639 acylglycerol metabolic process 3/502 128/18722 0.671045546757888 0.738581179943372 APOE/PLA2G15/GPX1 3 GO:0010907 positive regulation of glucose metabolic process 1/502 41/18722 0.672269735105169 0.739049380845178 IGF1 1 GO:0031062 positive regulation of histone methylation 1/502 41/18722 0.672269735105169 0.739049380845178 KMT2E 1 GO:0050892 intestinal absorption 1/502 41/18722 0.672269735105169 0.739049380845178 CD36 1 GO:1902116 negative regulation of organelle assembly 1/502 41/18722 0.672269735105169 0.739049380845178 NUPR1 1 GO:2000008 regulation of protein localization to cell surface 1/502 41/18722 0.672269735105169 0.739049380845178 TYROBP 1 GO:0009798 axis specification 2/502 86/18722 0.675274355075518 0.741823596907942 ETS2/CITED2 2 GO:0032413 negative regulation of ion transmembrane transporter activity 2/502 86/18722 0.675274355075518 0.741823596907942 CAB39/CALM2 2 GO:2001251 negative regulation of chromosome organization 2/502 86/18722 0.675274355075518 0.741823596907942 ATM/DUSP1 2 GO:0006638 neutral lipid metabolic process 3/502 129/18722 0.676161930923526 0.742622291655326 APOE/PLA2G15/GPX1 3 GO:0001505 regulation of neurotransmitter levels 5/502 213/18722 0.679280509903807 0.745673295862747 MEF2C/HNMT/NR4A1/PPT1/SLC1A3 5 GO:0043583 ear development 5/502 213/18722 0.679280509903807 0.745673295862747 MAF/MAFB/RBPJ/SLC4A7/ADAM10 5 GO:0006839 mitochondrial transport 6/502 254/18722 0.679423463480648 0.745673295862747 HSPA1A/UCP2/TSPO/STAT3/CHCHD10/BNIP3L 6 GO:0000266 mitochondrial fission 1/502 42/18722 0.681076575904762 0.74644972432933 STAT2 1 GO:0007212 dopamine receptor signaling pathway 1/502 42/18722 0.681076575904762 0.74644972432933 ARRB2 1 GO:0014003 oligodendrocyte development 1/502 42/18722 0.681076575904762 0.74644972432933 LYN 1 GO:0021795 cerebral cortex cell migration 1/502 42/18722 0.681076575904762 0.74644972432933 RTN4 1 GO:0006352 DNA-templated transcription, initiation 3/502 130/18722 0.681219411834344 0.74644972432933 SETX/JUN/ATF7IP 3 GO:0007029 endoplasmic reticulum organization 2/502 87/18722 0.681421786822905 0.74644972432933 RTN4/TRAM1 2 GO:0044070 regulation of anion transport 2/502 87/18722 0.681421786822905 0.74644972432933 SYK/PRNP 2 GO:1901606 alpha-amino acid catabolic process 2/502 87/18722 0.681421786822905 0.74644972432933 GLUL/GLS 2 GO:0006694 steroid biosynthetic process 4/502 173/18722 0.685364021022593 0.750590426432414 APOE/ASAH1/EGR1/TSPO 4 GO:0006661 phosphatidylinositol biosynthetic process 3/502 131/18722 0.686218054679522 0.751347862946147 ATM/PIK3R1/EFR3A 3 GO:0031110 regulation of microtubule polymerization or depolymerization 2/502 88/18722 0.687473839226348 0.752366685654385 HSPA1A/TAOK1 2 GO:1901657 glycosyl compound metabolic process 2/502 88/18722 0.687473839226348 0.752366685654385 TYMP/FUCA1 2 GO:0001504 neurotransmitter uptake 1/502 43/18722 0.68964721610261 0.752786225033194 SLC1A3 1 GO:0010171 body morphogenesis 1/502 43/18722 0.68964721610261 0.752786225033194 ATP6AP2 1 GO:0014014 negative regulation of gliogenesis 1/502 43/18722 0.68964721610261 0.752786225033194 TSPO 1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1/502 43/18722 0.68964721610261 0.752786225033194 FXYD5 1 GO:0021983 pituitary gland development 1/502 43/18722 0.68964721610261 0.752786225033194 RBPJ 1 GO:0042181 ketone biosynthetic process 1/502 43/18722 0.68964721610261 0.752786225033194 EGR1 1 GO:0045494 photoreceptor cell maintenance 1/502 43/18722 0.68964721610261 0.752786225033194 DRAM2 1 GO:0046717 acid secretion 1/502 43/18722 0.68964721610261 0.752786225033194 SGK1 1 GO:0090278 negative regulation of peptide hormone secretion 1/502 43/18722 0.68964721610261 0.752786225033194 UCP2 1 GO:0140353 lipid export from cell 1/502 43/18722 0.68964721610261 0.752786225033194 SPP1 1 GO:1901381 positive regulation of potassium ion transmembrane transport 1/502 43/18722 0.68964721610261 0.752786225033194 ATP1B1 1 GO:0006790 sulfur compound metabolic process 8/502 339/18722 0.691957687188634 0.755130045042373 HPGDS/PDK4/GPX1/PPT1/GNS/DSE/MGST2/MAT2A 8 GO:0051781 positive regulation of cell division 2/502 89/18722 0.693431196133568 0.756559602196671 PDGFC/TGFB1 2 GO:0050954 sensory perception of mechanical stimulus 4/502 175/18722 0.693986170610791 0.756986565726367 ICAM1/GPX1/SLC1A3/CCDC50 4 GO:0010565 regulation of cellular ketone metabolic process 3/502 133/18722 0.69603920005213 0.759046991853172 CD74/PDK4/EGR1 3 GO:0002066 columnar/cuboidal epithelial cell development 1/502 44/18722 0.697987978323098 0.759918189626418 HIF1A 1 GO:0005978 glycogen biosynthetic process 1/502 44/18722 0.697987978323098 0.759918189626418 IGF1 1 GO:0008542 visual learning 1/502 44/18722 0.697987978323098 0.759918189626418 HIF1A 1 GO:0009250 glucan biosynthetic process 1/502 44/18722 0.697987978323098 0.759918189626418 IGF1 1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 1/502 44/18722 0.697987978323098 0.759918189626418 MSN 1 GO:0089718 amino acid import across plasma membrane 1/502 44/18722 0.697987978323098 0.759918189626418 SLC1A3 1 GO:1903214 regulation of protein targeting to mitochondrion 1/502 44/18722 0.697987978323098 0.759918189626418 BNIP3L 1 GO:0032392 DNA geometric change 2/502 90/18722 0.699294573303519 0.760445861801147 CHD9/SETX 2 GO:0034644 cellular response to UV 2/502 90/18722 0.699294573303519 0.760445861801147 TIMP1/PIK3R1 2 GO:0035278 miRNA mediated inhibition of translation 2/502 90/18722 0.699294573303519 0.760445861801147 ZFP36/STAT3 2 GO:0040033 negative regulation of translation, ncRNA-mediated 2/502 90/18722 0.699294573303519 0.760445861801147 ZFP36/STAT3 2 GO:0048477 oogenesis 2/502 90/18722 0.699294573303519 0.760445861801147 IGF1/FOXO3 2 GO:0045974 regulation of translation, ncRNA-mediated 2/502 91/18722 0.705064716211033 0.766089789539285 ZFP36/STAT3 2 GO:0098661 inorganic anion transmembrane transport 2/502 91/18722 0.705064716211033 0.766089789539285 PRNP/SLC1A3 2 GO:0003254 regulation of membrane depolarization 1/502 45/18722 0.706105016275867 0.766089789539285 TSPO 1 GO:0006903 vesicle targeting 1/502 45/18722 0.706105016275867 0.766089789539285 FAM91A1 1 GO:0032309 icosanoid secretion 1/502 45/18722 0.706105016275867 0.766089789539285 SYK 1 GO:0035987 endodermal cell differentiation 1/502 45/18722 0.706105016275867 0.766089789539285 ITGB2 1 GO:0048546 digestive tract morphogenesis 1/502 45/18722 0.706105016275867 0.766089789539285 HIF1A 1 GO:0060119 inner ear receptor cell development 1/502 45/18722 0.706105016275867 0.766089789539285 SLC4A7 1 GO:1901985 positive regulation of protein acetylation 1/502 45/18722 0.706105016275867 0.766089789539285 TAOK1 1 GO:0022618 ribonucleoprotein complex assembly 5/502 220/18722 0.706306301855826 0.766089789539285 CELF2/ATM/SETX/SCAF11/ADAR 5 GO:0048705 skeletal system morphogenesis 5/502 220/18722 0.706306301855826 0.766089789539285 MEF2C/TGFBR2/ACP5/DHRS3/CITED2 5 GO:0015849 organic acid transport 7/502 303/18722 0.707052306235739 0.766719167521456 FOLR2/SLCO2B1/APOE/CD36/SYK/EMB/SLC1A3 7 GO:0045727 positive regulation of translation 3/502 136/18722 0.710332528726036 0.770095682654474 CD28/VIM/PLXNB2 3 GO:0007416 synapse assembly 4/502 179/18722 0.710722062356253 0.770179042608915 MEF2C/PLXND1/SDCBP/PLXNB2 4 GO:0001708 cell fate specification 2/502 92/18722 0.710742397945841 0.770179042608915 RBPJ/NRP1 2 GO:0009100 glycoprotein metabolic process 9/502 387/18722 0.713904070731693 0.771725229181188 IGF1/MAN1A1/MGAT4A/ITM2B/CST3/ST8SIA4/DSE/HIF1A/MGAT1 9 GO:0006195 purine nucleotide catabolic process 1/502 46/18722 0.714004319259724 0.771725229181188 SAMHD1 1 GO:0006383 transcription by RNA polymerase III 1/502 46/18722 0.714004319259724 0.771725229181188 IVNS1ABP 1 GO:0007019 microtubule depolymerization 1/502 46/18722 0.714004319259724 0.771725229181188 TAOK1 1 GO:0010830 regulation of myotube differentiation 1/502 46/18722 0.714004319259724 0.771725229181188 XBP1 1 GO:0031057 negative regulation of histone modification 1/502 46/18722 0.714004319259724 0.771725229181188 SPI1 1 GO:0035094 response to nicotine 1/502 46/18722 0.714004319259724 0.771725229181188 B2M 1 GO:0043462 regulation of ATPase activity 1/502 46/18722 0.714004319259724 0.771725229181188 ATP1B1 1 GO:0048701 embryonic cranial skeleton morphogenesis 1/502 46/18722 0.714004319259724 0.771725229181188 TGFBR2 1 GO:0070828 heterochromatin organization 1/502 46/18722 0.714004319259724 0.771725229181188 ATF7IP 1 GO:0090329 regulation of DNA-dependent DNA replication 1/502 46/18722 0.714004319259724 0.771725229181188 ATG7 1 GO:0071897 DNA biosynthetic process 4/502 180/18722 0.71480018563991 0.772404965842145 ARRB2/ATM/DUSP1/KLF4 4 GO:0008203 cholesterol metabolic process 3/502 137/18722 0.714980731058229 0.772419631451511 APOE/NPC2/ABCA1 3 GO:0019217 regulation of fatty acid metabolic process 2/502 93/18722 0.716328417202499 0.773694900298567 CD74/PDK4 2 GO:0007224 smoothened signaling pathway 3/502 138/18722 0.719571144303106 0.777015899520581 RB1/TGFBR2/PRKACB 3 GO:0001754 eye photoreceptor cell differentiation 1/502 47/18722 0.721691716546703 0.778176638720936 STAT3 1 GO:0016574 histone ubiquitination 1/502 47/18722 0.721691716546703 0.778176638720936 DTX3L 1 GO:0045601 regulation of endothelial cell differentiation 1/502 47/18722 0.721691716546703 0.778176638720936 TNFRSF1A 1 GO:0048483 autonomic nervous system development 1/502 47/18722 0.721691716546703 0.778176638720936 NRP1 1 GO:0051972 regulation of telomerase activity 1/502 47/18722 0.721691716546703 0.778176638720936 KLF4 1 GO:1903170 negative regulation of calcium ion transmembrane transport 1/502 47/18722 0.721691716546703 0.778176638720936 CALM2 1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 2/502 94/18722 0.721823596357876 0.778176638720936 ACTB/CCNL1 2 GO:0048709 oligodendrocyte differentiation 2/502 95/18722 0.727228779632964 0.783821140396573 TNFRSF1B/LYN 2 GO:0006111 regulation of gluconeogenesis 1/502 48/18722 0.729172881649437 0.785002036423155 RANBP2 1 GO:0035036 sperm-egg recognition 1/502 48/18722 0.729172881649437 0.785002036423155 FOLR2 1 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 1/502 48/18722 0.729172881649437 0.785002036423155 SAMHD1 1 GO:0090311 regulation of protein deacetylation 1/502 48/18722 0.729172881649437 0.785002036423155 SPRED1 1 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 1/502 48/18722 0.729172881649437 0.785002036423155 SDCBP 1 GO:0071826 ribonucleoprotein complex subunit organization 5/502 227/18722 0.731704372130838 0.787544072935611 CELF2/ATM/SETX/SCAF11/ADAR 5 GO:0006637 acyl-CoA metabolic process 2/502 96/18722 0.732544831335889 0.788081951106935 PDK4/PPT1 2 GO:0035383 thioester metabolic process 2/502 96/18722 0.732544831335889 0.788081951106935 PDK4/PPT1 2 GO:0035088 establishment or maintenance of apical/basal cell polarity 1/502 49/18722 0.736453336474969 0.790631964384592 MSN 1 GO:0046580 negative regulation of Ras protein signal transduction 1/502 49/18722 0.736453336474969 0.790631964384592 TIMP2 1 GO:0046605 regulation of centrosome cycle 1/502 49/18722 0.736453336474969 0.790631964384592 ATF5 1 GO:0048168 regulation of neuronal synaptic plasticity 1/502 49/18722 0.736453336474969 0.790631964384592 APOE 1 GO:0060986 endocrine hormone secretion 1/502 49/18722 0.736453336474969 0.790631964384592 RAB8B 1 GO:0061245 establishment or maintenance of bipolar cell polarity 1/502 49/18722 0.736453336474969 0.790631964384592 MSN 1 GO:0086009 membrane repolarization 1/502 49/18722 0.736453336474969 0.790631964384592 ATP1B1 1 GO:1901799 negative regulation of proteasomal protein catabolic process 1/502 49/18722 0.736453336474969 0.790631964384592 SDCBP 1 GO:1990573 potassium ion import across plasma membrane 1/502 49/18722 0.736453336474969 0.790631964384592 ATP1B1 1 GO:0033044 regulation of chromosome organization 4/502 187/18722 0.742167648361058 0.795837319419798 RB1/ATM/DUSP1/ATF7IP 4 GO:1904029 regulation of cyclin-dependent protein kinase activity 2/502 98/18722 0.742913087695821 0.795837319419798 ACTB/CCNL1 2 GO:0006220 pyrimidine nucleotide metabolic process 1/502 50/18722 0.743538455368 0.795837319419798 TYMP 1 GO:0007632 visual behavior 1/502 50/18722 0.743538455368 0.795837319419798 HIF1A 1 GO:0018023 peptidyl-lysine trimethylation 1/502 50/18722 0.743538455368 0.795837319419798 KMT2E 1 GO:0043268 positive regulation of potassium ion transport 1/502 50/18722 0.743538455368 0.795837319419798 ATP1B1 1 GO:0046460 neutral lipid biosynthetic process 1/502 50/18722 0.743538455368 0.795837319419798 PLA2G15 1 GO:0046463 acylglycerol biosynthetic process 1/502 50/18722 0.743538455368 0.795837319419798 PLA2G15 1 GO:0050873 brown fat cell differentiation 1/502 50/18722 0.743538455368 0.795837319419798 METRNL 1 GO:0060688 regulation of morphogenesis of a branching structure 1/502 50/18722 0.743538455368 0.795837319419798 RTN4 1 GO:0090102 cochlea development 1/502 50/18722 0.743538455368 0.795837319419798 ADAM10 1 GO:0099054 presynapse assembly 1/502 50/18722 0.743538455368 0.795837319419798 SDCBP 1 GO:1903747 regulation of establishment of protein localization to mitochondrion 1/502 50/18722 0.743538455368 0.795837319419798 BNIP3L 1 GO:0021549 cerebellum development 2/502 99/18722 0.747967106668974 0.800392282084356 AIF1/FCGR2B 2 GO:0009101 glycoprotein biosynthetic process 7/502 317/18722 0.749692788456878 0.801918509542431 IGF1/MAN1A1/MGAT4A/ITM2B/ST8SIA4/DSE/MGAT1 7 GO:0007269 neurotransmitter secretion 3/502 145/18722 0.750106855867325 0.801918509542431 MEF2C/NR4A1/PPT1 3 GO:0099643 signal release from synapse 3/502 145/18722 0.750106855867325 0.801918509542431 MEF2C/NR4A1/PPT1 3 GO:0009948 anterior/posterior axis specification 1/502 51/18722 0.750433469046516 0.801918509542431 ETS2 1 GO:0060632 regulation of microtubule-based movement 1/502 51/18722 0.750433469046516 0.801918509542431 LAMP1 1 GO:0065002 intracellular protein transmembrane transport 1/502 51/18722 0.750433469046516 0.801918509542431 TRAM1 1 GO:0015980 energy derivation by oxidation of organic compounds 7/502 318/18722 0.752562407501019 0.803664092472886 IGF1/PYGL/NUPR1/HIF1A/GAA/CHCHD10/IFNAR1 7 GO:0006626 protein targeting to mitochondrion 2/502 100/18722 0.75293561970979 0.803664092472886 TSPO/BNIP3L 2 GO:0006641 triglyceride metabolic process 2/502 100/18722 0.75293561970979 0.803664092472886 APOE/GPX1 2 GO:0060079 excitatory postsynaptic potential 2/502 100/18722 0.75293561970979 0.803664092472886 MEF2C/ARRB2 2 GO:0061640 cytoskeleton-dependent cytokinesis 2/502 100/18722 0.75293561970979 0.803664092472886 ACTR2/RHOB 2 GO:0007043 cell-cell junction assembly 3/502 146/18722 0.754244367938343 0.804875304748045 MTDH/PECAM1/ACTB 3 GO:0030514 negative regulation of BMP signaling pathway 1/502 52/18722 0.757143468432658 0.807038176260248 SKIL 1 GO:0032206 positive regulation of telomere maintenance 1/502 52/18722 0.757143468432658 0.807038176260248 ATM 1 GO:0043090 amino acid import 1/502 52/18722 0.757143468432658 0.807038176260248 SLC1A3 1 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 1/502 52/18722 0.757143468432658 0.807038176260248 DAB2 1 GO:0072523 purine-containing compound catabolic process 1/502 52/18722 0.757143468432658 0.807038176260248 SAMHD1 1 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7/502 320/18722 0.758231218819744 0.807183413947111 CELF2/QKI/MBNL1/SETX/DDX17/DDX5/SCAF11 7 GO:0000398 mRNA splicing, via spliceosome 7/502 320/18722 0.758231218819744 0.807183413947111 CELF2/QKI/MBNL1/SETX/DDX17/DDX5/SCAF11 7 GO:0009416 response to light stimulus 7/502 320/18722 0.758231218819744 0.807183413947111 FOS/DUSP1/GPX1/TIMP1/HIF1A/SLC1A3/PIK3R1 7 GO:0001889 liver development 3/502 147/18722 0.758326657374437 0.807183413947111 XBP1/UCP2/CITED2 3 GO:1902652 secondary alcohol metabolic process 3/502 147/18722 0.758326657374437 0.807183413947111 APOE/NPC2/ABCA1 3 GO:1902850 microtubule cytoskeleton organization involved in mitosis 3/502 147/18722 0.758326657374437 0.807183413947111 HSPA1A/CLTC/TACC1 3 GO:0000209 protein polyubiquitination 5/502 236/18722 0.761971107996556 0.810876085942505 IFI27/WWP1/TRIM22/DTX3L/TRIM38 5 GO:0070507 regulation of microtubule cytoskeleton organization 3/502 148/18722 0.762354074717169 0.811097044535792 HSPA1A/CLTC/TAOK1 3 GO:1904063 negative regulation of cation transmembrane transport 2/502 102/18722 0.762619903183956 0.811193302398018 CAB39/CALM2 2 GO:0032210 regulation of telomere maintenance via telomerase 1/502 53/18722 0.763673408381603 0.81175394925857 ATM 1 GO:0045806 negative regulation of endocytosis 1/502 53/18722 0.763673408381603 0.81175394925857 SDCBP 1 GO:0071715 icosanoid transport 1/502 53/18722 0.763673408381603 0.81175394925857 SYK 1 GO:0009411 response to UV 3/502 149/18722 0.766326981362909 0.814387460552451 GPX1/TIMP1/PIK3R1 3 GO:0002027 regulation of heart rate 2/502 103/18722 0.767337587665418 0.815274157220998 SLC8A1/CALM2 2 GO:0000375 RNA splicing, via transesterification reactions 7/502 324/18722 0.769287762804934 0.817158482373278 CELF2/QKI/MBNL1/SETX/DDX17/DDX5/SCAF11 7 GO:0010524 positive regulation of calcium ion transport into cytosol 1/502 54/18722 0.770028111311189 0.817194320469273 CALM2 1 GO:0014888 striated muscle adaptation 1/502 54/18722 0.770028111311189 0.817194320469273 GSN 1 GO:0035065 regulation of histone acetylation 1/502 54/18722 0.770028111311189 0.817194320469273 SPI1 1 GO:0043647 inositol phosphate metabolic process 1/502 54/18722 0.770028111311189 0.817194320469273 PLEK 1 GO:0061008 hepaticobiliary system development 3/502 150/18722 0.770245749002919 0.817237806166858 XBP1/UCP2/CITED2 3 GO:1901890 positive regulation of cell junction assembly 2/502 104/18722 0.771973591835372 0.818883246005602 NRP1/IQGAP1 2 GO:0048592 eye morphogenesis 3/502 151/18722 0.774110759078273 0.820962029228815 STAT3/HIF1A/CITED2 3 GO:0010676 positive regulation of cellular carbohydrate metabolic process 1/502 55/18722 0.776212270734897 0.822248217178758 IGF1 1 GO:0031113 regulation of microtubule polymerization 1/502 55/18722 0.776212270734897 0.822248217178758 HSPA1A 1 GO:0044091 membrane biogenesis 1/502 55/18722 0.776212270734897 0.822248217178758 SERINC1 1 GO:0046164 alcohol catabolic process 1/502 55/18722 0.776212270734897 0.822248217178758 APOE 1 GO:0098900 regulation of action potential 1/502 55/18722 0.776212270734897 0.822248217178758 CD36 1 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 9/502 412/18722 0.778759508902213 0.82475766670825 DAB2/IFI27/MAN1A1/ARRB2/WWP1/HSPA1A/SDCBP/FEM1B/HERPUD1 9 GO:0048562 embryonic organ morphogenesis 6/502 285/18722 0.779546999185727 0.825402705020181 MEF2C/MAFB/TGFBR2/ENG/HIF1A/CITED2 6 GO:0099565 chemical synaptic transmission, postsynaptic 2/502 106/18722 0.781004477648501 0.826541362139286 MEF2C/ARRB2 2 GO:0007338 single fertilization 3/502 153/18722 0.781681077880121 0.826541362139286 FOLR2/LHFPL2/GNPDA1 3 GO:0015800 acidic amino acid transport 1/502 56/18722 0.782230454700777 0.826541362139286 SLC1A3 1 GO:0022029 telencephalon cell migration 1/502 56/18722 0.782230454700777 0.826541362139286 RTN4 1 GO:0031122 cytoplasmic microtubule organization 1/502 56/18722 0.782230454700777 0.826541362139286 CCDC88A 1 GO:0048255 mRNA stabilization 1/502 56/18722 0.782230454700777 0.826541362139286 ZFP36 1 GO:0051058 negative regulation of small GTPase mediated signal transduction 1/502 56/18722 0.782230454700777 0.826541362139286 TIMP2 1 GO:0051653 spindle localization 1/502 56/18722 0.782230454700777 0.826541362139286 ACTR2 1 GO:0090175 regulation of establishment of planar polarity 1/502 56/18722 0.782230454700777 0.826541362139286 DAB2 1 GO:0021761 limbic system development 2/502 107/18722 0.785401333372477 0.829512915109835 NRP1/BTG2 2 GO:0036503 ERAD pathway 2/502 107/18722 0.785401333372477 0.829512915109835 MAN1A1/HERPUD1 2 GO:0002011 morphogenesis of an epithelial sheet 1/502 57/18722 0.788087109138804 0.831210890760626 CD44 1 GO:0006695 cholesterol biosynthetic process 1/502 57/18722 0.788087109138804 0.831210890760626 APOE 1 GO:0050891 multicellular organismal water homeostasis 1/502 57/18722 0.788087109138804 0.831210890760626 PRKACB 1 GO:0051205 protein insertion into membrane 1/502 57/18722 0.788087109138804 0.831210890760626 TRAM1 1 GO:1902017 regulation of cilium assembly 1/502 57/18722 0.788087109138804 0.831210890760626 CCDC88A 1 GO:1902653 secondary alcohol biosynthetic process 1/502 57/18722 0.788087109138804 0.831210890760626 APOE 1 GO:0022037 metencephalon development 2/502 108/18722 0.78972045491377 0.832364279888607 AIF1/FCGR2B 2 GO:0034440 lipid oxidation 2/502 108/18722 0.78972045491377 0.832364279888607 ALOX5/PDK4 2 GO:0140053 mitochondrial gene expression 2/502 108/18722 0.78972045491377 0.832364279888607 FOXO3/CHCHD10 2 GO:0044282 small molecule catabolic process 8/502 376/18722 0.793469015261696 0.835883499423717 APOE/HNMT/GLUL/PLA2G15/GLS/NPL/MGAT1/GNPDA1 8 GO:0007131 reciprocal meiotic recombination 1/502 58/18722 0.793786561119105 0.835883499423717 ATM 1 GO:0140527 reciprocal homologous recombination 1/502 58/18722 0.793786561119105 0.835883499423717 ATM 1 GO:0032410 negative regulation of transporter activity 2/502 109/18722 0.793962839703375 0.835883499423717 CAB39/CALM2 2 GO:0034766 negative regulation of ion transmembrane transport 2/502 109/18722 0.793962839703375 0.835883499423717 CAB39/CALM2 2 GO:0006767 water-soluble vitamin metabolic process 1/502 59/18722 0.799333022023424 0.840580713771394 SLC2A3 1 GO:0021885 forebrain cell migration 1/502 59/18722 0.799333022023424 0.840580713771394 RTN4 1 GO:0051055 negative regulation of lipid biosynthetic process 1/502 59/18722 0.799333022023424 0.840580713771394 APOE 1 GO:0051568 histone H3-K4 methylation 1/502 59/18722 0.799333022023424 0.840580713771394 KMT2E 1 GO:2001258 negative regulation of cation channel activity 1/502 59/18722 0.799333022023424 0.840580713771394 CALM2 1 GO:0006081 cellular aldehyde metabolic process 1/502 60/18722 0.804730590632128 0.845872236369967 ALDH1A1 1 GO:0035825 homologous recombination 1/502 60/18722 0.804730590632128 0.845872236369967 ATM 1 GO:0035601 protein deacylation 2/502 112/18722 0.80623958029771 0.84726585607842 SPRED1/PPT1 2 GO:0051650 establishment of vesicle localization 3/502 161/18722 0.809894062587027 0.85042726801016 MYO5A/MYO1F/FAM91A1 3 GO:0019748 secondary metabolic process 1/502 61/18722 0.809983256129002 0.85042726801016 ZEB2 1 GO:0043966 histone H3 acetylation 1/502 61/18722 0.809983256129002 0.85042726801016 SPI1 1 GO:1904356 regulation of telomere maintenance via telomere lengthening 1/502 61/18722 0.809983256129002 0.85042726801016 ATM 1 GO:0006836 neurotransmitter transport 4/502 208/18722 0.812274787960868 0.852639702542994 MEF2C/NR4A1/PPT1/SLC1A3 4 GO:0034250 positive regulation of cellular amide metabolic process 3/502 162/18722 0.813195200288404 0.853412204295408 CD28/VIM/PLXNB2 3 GO:0007062 sister chromatid cohesion 1/502 62/18722 0.81509490102602 0.854243092919431 RB1 1 GO:0007588 excretion 1/502 62/18722 0.81509490102602 0.854243092919431 GNAI2 1 GO:0009116 nucleoside metabolic process 1/502 62/18722 0.81509490102602 0.854243092919431 TYMP 1 GO:0019933 cAMP-mediated signaling 1/502 62/18722 0.81509490102602 0.854243092919431 AHR 1 GO:0031124 mRNA 3'-end processing 1/502 62/18722 0.81509490102602 0.854243092919431 ZFP36L1 1 GO:0048663 neuron fate commitment 1/502 62/18722 0.81509490102602 0.854243092919431 RBPJ 1 GO:1902373 negative regulation of mRNA catabolic process 1/502 63/18722 0.820069304010207 0.859067164934606 ZFP36 1 GO:2000756 regulation of peptidyl-lysine acetylation 1/502 63/18722 0.820069304010207 0.859067164934606 SPI1 1 GO:0098732 macromolecule deacylation 2/502 116/18722 0.821595008018129 0.860470569864584 SPRED1/PPT1 2 GO:0016126 sterol biosynthetic process 1/502 64/18722 0.824910142714686 0.862380637332913 APOE 1 GO:0017156 calcium-ion regulated exocytosis 1/502 64/18722 0.824910142714686 0.862380637332913 GNAI2 1 GO:0030104 water homeostasis 1/502 64/18722 0.824910142714686 0.862380637332913 PRKACB 1 GO:0046530 photoreceptor cell differentiation 1/502 64/18722 0.824910142714686 0.862380637332913 STAT3 1 GO:0046888 negative regulation of hormone secretion 1/502 64/18722 0.824910142714686 0.862380637332913 UCP2 1 GO:0098930 axonal transport 1/502 64/18722 0.824910142714686 0.862380637332913 HIF1A 1 GO:1900076 regulation of cellular response to insulin stimulus 1/502 64/18722 0.824910142714686 0.862380637332913 GNAI2 1 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 1/502 64/18722 0.824910142714686 0.862380637332913 SDCBP 1 GO:0006936 muscle contraction 7/502 347/18722 0.825733121303682 0.863045960043116 ATP1B1/SLC8A1/NR4A1/TPM3/GAA/CALM2/GSN 7 GO:0033692 cellular polysaccharide biosynthetic process 1/502 65/18722 0.829620996415899 0.865935633894393 IGF1 1 GO:0035418 protein localization to synapse 1/502 65/18722 0.829620996415899 0.865935633894393 ADAM10 1 GO:0043489 RNA stabilization 1/502 65/18722 0.829620996415899 0.865935633894393 ZFP36 1 GO:0061512 protein localization to cilium 1/502 65/18722 0.829620996415899 0.865935633894393 CCDC88A 1 GO:0090307 mitotic spindle assembly 1/502 65/18722 0.829620996415899 0.865935633894393 HSPA1A 1 GO:1902475 L-alpha-amino acid transmembrane transport 1/502 65/18722 0.829620996415899 0.865935633894393 SLC1A3 1 GO:0006260 DNA replication 5/502 260/18722 0.830007344883765 0.86614346434295 CCDC88A/SAMHD1/NFIC/ATG7/JUN 5 GO:0007601 visual perception 4/502 215/18722 0.831879700552189 0.867829090166352 TGFBI/PPT1/DHRS3/DRAM2 4 GO:0000070 mitotic sister chromatid segregation 3/502 168/18722 0.831997841523513 0.867829090166352 RB1/ATM/DUSP1 3 GO:0051321 meiotic cell cycle 5/502 261/18722 0.83246194788729 0.868117441597522 ATM/DUSP1/ACTR2/PRKACB/PRKAR1A 5 GO:0050909 sensory perception of taste 1/502 66/18722 0.834205348658983 0.869151788940643 CD36 1 GO:1902476 chloride transmembrane transport 1/502 66/18722 0.834205348658983 0.869151788940643 SLC1A3 1 GO:1905953 negative regulation of lipid localization 1/502 66/18722 0.834205348658983 0.869151788940643 ABCA1 1 GO:2000272 negative regulation of signaling receptor activity 1/502 66/18722 0.834205348658983 0.869151788940643 SNX6 1 GO:0048593 camera-type eye morphogenesis 2/502 120/18722 0.835850638060766 0.870473897269046 HIF1A/CITED2 2 GO:0072655 establishment of protein localization to mitochondrion 2/502 120/18722 0.835850638060766 0.870473897269046 TSPO/BNIP3L 2 GO:0000280 nuclear division 9/502 439/18722 0.836133389867499 0.870572374865418 IGF1/CD28/RB1/HSPA1A/ATM/DUSP1/ACTR2/EPS8/PRKAR1A 9 GO:0006513 protein monoubiquitination 1/502 67/18722 0.838666589813206 0.872228337337206 DTX3L 1 GO:0009880 embryonic pattern specification 1/502 67/18722 0.838666589813206 0.872228337337206 NRP1 1 GO:0032890 regulation of organic acid transport 1/502 67/18722 0.838666589813206 0.872228337337206 SYK 1 GO:0043967 histone H4 acetylation 1/502 67/18722 0.838666589813206 0.872228337337206 SPI1 1 GO:0048814 regulation of dendrite morphogenesis 1/502 67/18722 0.838666589813206 0.872228337337206 ACTR2 1 GO:0042752 regulation of circadian rhythm 2/502 121/18722 0.839250123122183 0.872639035640193 ATG7/ZFHX3 2 GO:0050953 sensory perception of light stimulus 4/502 219/18722 0.842298149615952 0.875365903138366 TGFBI/PPT1/DHRS3/DRAM2 4 GO:0031109 microtubule polymerization or depolymerization 2/502 122/18722 0.842585796639155 0.875365903138366 HSPA1A/TAOK1 2 GO:0009247 glycolipid biosynthetic process 1/502 68/18722 0.843008019559321 0.875365903138366 ST8SIA4 1 GO:0034394 protein localization to cell surface 1/502 68/18722 0.843008019559321 0.875365903138366 TYROBP 1 GO:0051148 negative regulation of muscle cell differentiation 1/502 68/18722 0.843008019559321 0.875365903138366 XBP1 1 GO:1904888 cranial skeletal system development 1/502 68/18722 0.843008019559321 0.875365903138366 TGFBR2 1 GO:0071482 cellular response to light stimulus 2/502 123/18722 0.845858627999759 0.87812881802668 TIMP1/PIK3R1 2 GO:0000910 cytokinesis 3/502 173/18722 0.846403977658352 0.878372738886385 ACTR2/RHOB/CALM2 3 GO:0048285 organelle fission 10/502 488/18722 0.846721773796617 0.878372738886385 IGF1/CD28/RB1/HSPA1A/ATM/DUSP1/ACTR2/STAT2/EPS8/PRKAR1A 10 GO:0007004 telomere maintenance via telomerase 1/502 69/18722 0.847232849310646 0.878372738886385 ATM 1 GO:0015807 L-amino acid transport 1/502 69/18722 0.847232849310646 0.878372738886385 SLC1A3 1 GO:0031060 regulation of histone methylation 1/502 69/18722 0.847232849310646 0.878372738886385 KMT2E 1 GO:0050805 negative regulation of synaptic transmission 1/502 69/18722 0.847232849310646 0.878372738886385 GNAI2 1 GO:0051053 negative regulation of DNA metabolic process 2/502 125/18722 0.852219611458708 0.883146936068097 ATM/DUSP1 2 GO:2000027 regulation of animal organ morphogenesis 2/502 125/18722 0.852219611458708 0.883146936068097 DAB2/CITED2 2 GO:0000281 mitotic cytokinesis 1/502 71/18722 0.855345127221693 0.88618735913271 RHOB 1 GO:0051648 vesicle localization 3/502 177/18722 0.857145823776513 0.88785413810796 MYO5A/MYO1F/FAM91A1 3 GO:0006486 protein glycosylation 4/502 226/18722 0.859225244625564 0.889225427461669 MAN1A1/MGAT4A/ST8SIA4/MGAT1 4 GO:0043413 macromolecule glycosylation 4/502 226/18722 0.859225244625564 0.889225427461669 MAN1A1/MGAT4A/ST8SIA4/MGAT1 4 GO:0001736 establishment of planar polarity 1/502 72/18722 0.859238577767761 0.889225427461669 DAB2 1 GO:0007164 establishment of tissue polarity 1/502 72/18722 0.859238577767761 0.889225427461669 DAB2 1 GO:0033865 nucleoside bisphosphate metabolic process 2/502 128/18722 0.861313641109635 0.890775073501715 PDK4/PPT1 2 GO:0033875 ribonucleoside bisphosphate metabolic process 2/502 128/18722 0.861313641109635 0.890775073501715 PDK4/PPT1 2 GO:0034032 purine nucleoside bisphosphate metabolic process 2/502 128/18722 0.861313641109635 0.890775073501715 PDK4/PPT1 2 GO:0051937 catecholamine transport 1/502 73/18722 0.863027437497551 0.891750039281588 ACTB 1 GO:0070988 demethylation 1/502 73/18722 0.863027437497551 0.891750039281588 JMJD1C 1 GO:0072088 nephron epithelium morphogenesis 1/502 73/18722 0.863027437497551 0.891750039281588 STAT1 1 GO:0086003 cardiac muscle cell contraction 1/502 73/18722 0.863027437497551 0.891750039281588 GSN 1 GO:0140694 non-membrane-bounded organelle assembly 7/502 367/18722 0.865485718991856 0.894090427882163 LCP1/HSPA1A/MEF2A/MSN/GSN/PRKAR1A/AKAP13 7 GO:0045333 cellular respiration 4/502 230/18722 0.868185271484071 0.896678960903174 NUPR1/HIF1A/CHCHD10/IFNAR1 4 GO:0000723 telomere maintenance 2/502 131/18722 0.869893147276403 0.897663207673046 ATM/SP100 2 GO:0006094 gluconeogenesis 1/502 75/18722 0.870302526245917 0.897663207673046 RANBP2 1 GO:0006278 RNA-dependent DNA biosynthetic process 1/502 75/18722 0.870302526245917 0.897663207673046 ATM 1 GO:0008088 axo-dendritic transport 1/502 75/18722 0.870302526245917 0.897663207673046 HIF1A 1 GO:1902369 negative regulation of RNA catabolic process 1/502 75/18722 0.870302526245917 0.897663207673046 ZFP36 1 GO:1903363 negative regulation of cellular protein catabolic process 1/502 75/18722 0.870302526245917 0.897663207673046 SDCBP 1 GO:0009123 nucleoside monophosphate metabolic process 1/502 76/18722 0.873794140544439 0.900862869212966 TYMP 1 GO:0072028 nephron morphogenesis 1/502 76/18722 0.873794140544439 0.900862869212966 STAT1 1 GO:0007051 spindle organization 3/502 184/18722 0.874369041349201 0.901254720428121 HSPA1A/CLTC/TACC1 3 GO:0140013 meiotic nuclear division 3/502 185/18722 0.876673616497767 0.903428859416054 ATM/ACTR2/PRKAR1A 3 GO:0006367 transcription initiation from RNA polymerase II promoter 1/502 77/18722 0.877191938541152 0.903761672091619 ATF7IP 1 GO:0019319 hexose biosynthetic process 1/502 78/18722 0.8804984360929 0.906562600793624 RANBP2 1 GO:0034637 cellular carbohydrate biosynthetic process 1/502 78/18722 0.8804984360929 0.906562600793624 IGF1 1 GO:1901616 organic hydroxy compound catabolic process 1/502 78/18722 0.8804984360929 0.906562600793624 APOE 1 GO:0006446 regulation of translational initiation 1/502 79/18722 0.88371608172052 0.909470654958649 EIF4G3 1 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 1/502 79/18722 0.88371608172052 0.909470654958649 RNASE6 1 GO:0009060 aerobic respiration 3/502 189/18722 0.885521389194101 0.911010710802549 NUPR1/HIF1A/CHCHD10 3 GO:0060078 regulation of postsynaptic membrane potential 2/502 137/18722 0.885606391370312 0.911010710802549 MEF2C/ARRB2 2 GO:0021766 hippocampus development 1/502 80/18722 0.88684725840755 0.911678981642962 BTG2 1 GO:0032204 regulation of telomere maintenance 1/502 80/18722 0.88684725840755 0.911678981642962 ATM 1 GO:0051303 establishment of chromosome localization 1/502 80/18722 0.88684725840755 0.911678981642962 ACTR2 1 GO:0009566 fertilization 3/502 190/18722 0.887643068771567 0.912294342621032 FOLR2/LHFPL2/GNPDA1 3 GO:0070085 glycosylation 4/502 240/18722 0.888468711926014 0.912940084711182 MAN1A1/MGAT4A/ST8SIA4/MGAT1 4 GO:0001942 hair follicle development 1/502 81/18722 0.88989428535098 0.913998881890238 RBPJ 1 GO:0010833 telomere maintenance via telomere lengthening 1/502 81/18722 0.88989428535098 0.913998881890238 ATM 1 GO:0007032 endosome organization 1/502 82/18722 0.89285941966533 0.916027428558842 DNAJC13 1 GO:0008543 fibroblast growth factor receptor signaling pathway 1/502 82/18722 0.89285941966533 0.916027428558842 SETX 1 GO:0046364 monosaccharide biosynthetic process 1/502 82/18722 0.89285941966533 0.916027428558842 RANBP2 1 GO:0050000 chromosome localization 1/502 82/18722 0.89285941966533 0.916027428558842 ACTR2 1 GO:0072527 pyrimidine-containing compound metabolic process 1/502 82/18722 0.89285941966533 0.916027428558842 TYMP 1 GO:0043543 protein acylation 4/502 243/18722 0.893998230800727 0.916992420329083 SPI1/GLUL/NUPR1/TAOK1 4 GO:0006119 oxidative phosphorylation 2/502 141/18722 0.895086381602448 0.917905032430265 NUPR1/CHCHD10 2 GO:0046785 microtubule polymerization 1/502 83/18722 0.895744858041296 0.918376709507765 HSPA1A 1 GO:0009953 dorsal/ventral pattern formation 1/502 84/18722 0.898552738360158 0.920643403688614 PRKACB 1 GO:0022404 molting cycle process 1/502 84/18722 0.898552738360158 0.920643403688614 RBPJ 1 GO:0022405 hair cycle process 1/502 84/18722 0.898552738360158 0.920643403688614 RBPJ 1 GO:0034763 negative regulation of transmembrane transport 2/502 143/18722 0.899547773784599 0.9214588134472 CAB39/CALM2 2 GO:0098773 skin epidermis development 1/502 85/18722 0.901285141265148 0.923034107481199 RBPJ 1 GO:0046928 regulation of neurotransmitter secretion 1/502 86/18722 0.903944091690908 0.925552316990293 MEF2C 1 GO:0060041 retina development in camera-type eye 2/502 147/18722 0.907945211656955 0.929443361169523 NRP1/HIF1A 2 GO:0006473 protein acetylation 3/502 201/18722 0.908761623269 0.929867566742401 SPI1/NUPR1/TAOK1 3 GO:0065004 protein-DNA complex assembly 3/502 201/18722 0.908761623269 0.929867566742401 TCF4/RB1/ATF7IP 3 GO:0000819 sister chromatid segregation 3/502 202/18722 0.910491406458211 0.931225568488987 RB1/ATM/DUSP1 3 GO:1903046 meiotic cell cycle process 3/502 202/18722 0.910491406458211 0.931225568488987 ATM/ACTR2/PRKAR1A 3 GO:0090596 sensory organ morphogenesis 4/502 256/18722 0.91527124892282 0.935907338089515 MAFB/STAT3/HIF1A/CITED2 4 GO:0006261 DNA-dependent DNA replication 2/502 151/18722 0.915682809740724 0.93612125477582 SAMHD1/ATG7 2 GO:0002065 columnar/cuboidal epithelial cell differentiation 1/502 91/18722 0.916204214017834 0.936447347336832 HIF1A 1 GO:0031056 regulation of histone modification 2/502 152/18722 0.917519615173941 0.937584656460051 SPI1/KMT2E 2 GO:0031058 positive regulation of histone modification 1/502 92/18722 0.918462036172471 0.937719130287763 KMT2E 1 GO:0032465 regulation of cytokinesis 1/502 92/18722 0.918462036172471 0.937719130287763 CALM2 1 GO:1903312 negative regulation of mRNA metabolic process 1/502 92/18722 0.918462036172471 0.937719130287763 ZFP36 1 GO:1903351 cellular response to dopamine 1/502 92/18722 0.918462036172471 0.937719130287763 ARRB2 1 GO:0045132 meiotic chromosome segregation 1/502 93/18722 0.920659140726493 0.939340358403343 ACTR2 1 GO:0060993 kidney morphogenesis 1/502 93/18722 0.920659140726493 0.939340358403343 STAT1 1 GO:1903350 response to dopamine 1/502 93/18722 0.920659140726493 0.939340358403343 ARRB2 1 GO:0048704 embryonic skeletal system morphogenesis 1/502 94/18722 0.922797157332607 0.9411167348896 TGFBR2 1 GO:0010970 transport along microtubule 2/502 155/18722 0.922807070786689 0.9411167348896 LAMP1/HIF1A 2 GO:0042180 cellular ketone metabolic process 3/502 211/18722 0.924770120974309 0.942910861720775 CD74/PDK4/EGR1 3 GO:0007030 Golgi organization 2/502 157/18722 0.926153032267715 0.943974031577562 ATP8B4/VMP1 2 GO:0030258 lipid modification 3/502 212/18722 0.926220953162679 0.943974031577562 APOE/ALOX5/PDK4 3 GO:0042472 inner ear morphogenesis 1/502 96/18722 0.926902228206387 0.944460288035847 MAFB 1 GO:0032259 methylation 6/502 364/18722 0.927941667174382 0.945311198491233 SPI1/FOS/HNMT/BTG2/ATF7IP/KMT2E 6 GO:0043414 macromolecule methylation 5/502 316/18722 0.928800188920509 0.945842700857307 SPI1/FOS/BTG2/ATF7IP/KMT2E 5 GO:0070252 actin-mediated cell contraction 1/502 97/18722 0.92887232814413 0.945842700857307 GSN 1 GO:0032200 telomere organization 2/502 159/18722 0.929361941075278 0.946132997230245 ATM/SP100 2 GO:0003333 amino acid transmembrane transport 1/502 98/18722 0.930789433715762 0.947377760257231 SLC1A3 1 GO:0009062 fatty acid catabolic process 1/502 100/18722 0.934470314614264 0.950705888587109 PLA2G15 1 GO:0051588 regulation of neurotransmitter transport 1/502 100/18722 0.934470314614264 0.950705888587109 MEF2C 1 GO:0006476 protein deacetylation 1/502 101/18722 0.936236822081971 0.952084312805275 SPRED1 1 GO:0051963 regulation of synapse assembly 1/502 101/18722 0.936236822081971 0.952084312805275 MEF2C 1 GO:0045833 negative regulation of lipid metabolic process 1/502 102/18722 0.937955801477 0.9534132141579 APOE 1 GO:1990542 mitochondrial transmembrane transport 1/502 102/18722 0.937955801477 0.9534132141579 UCP2 1 GO:0019395 fatty acid oxidation 1/502 103/18722 0.939628529063389 0.954903685291572 PDK4 1 GO:0098813 nuclear chromosome segregation 4/502 281/18722 0.945768572571321 0.960203368007369 RB1/ATM/DUSP1/ACTR2 4 GO:0042303 molting cycle 1/502 107/18722 0.945881268484561 0.960203368007369 RBPJ 1 GO:0042633 hair cycle 1/502 107/18722 0.945881268484561 0.960203368007369 RBPJ 1 GO:0071868 cellular response to monoamine stimulus 1/502 107/18722 0.945881268484561 0.960203368007369 ARRB2 1 GO:0071870 cellular response to catecholamine stimulus 1/502 107/18722 0.945881268484561 0.960203368007369 ARRB2 1 GO:0022412 cellular process involved in reproduction in multicellular organism 6/502 384/18722 0.947368881915729 0.961502511571339 FOLR2/IGF1/ARRB2/QKI/FOXO3/PRKAR1A 6 GO:0006939 smooth muscle contraction 1/502 110/18722 0.950142820242536 0.963683553265067 SLC8A1 1 GO:0030317 flagellated sperm motility 1/502 110/18722 0.950142820242536 0.963683553265067 PLTP 1 GO:0097722 sperm motility 1/502 110/18722 0.950142820242536 0.963683553265067 PLTP 1 GO:0006805 xenobiotic metabolic process 1/502 111/18722 0.951487560422971 0.964201852029937 AHR 1 GO:0071867 response to monoamine 1/502 111/18722 0.951487560422971 0.964201852029937 ARRB2 1 GO:0071869 response to catecholamine 1/502 111/18722 0.951487560422971 0.964201852029937 ARRB2 1 GO:0090288 negative regulation of cellular response to growth factor stimulus 1/502 111/18722 0.951487560422971 0.964201852029937 SKIL 1 GO:0034968 histone lysine methylation 1/502 115/18722 0.956514119158381 0.96857489792818 KMT2E 1 GO:0042471 ear morphogenesis 1/502 115/18722 0.956514119158381 0.96857489792818 MAFB 1 GO:0090630 activation of GTPase activity 1/502 115/18722 0.956514119158381 0.96857489792818 GPR65 1 GO:0006479 protein methylation 2/502 181/18722 0.956965234594714 0.96857489792818 BTG2/KMT2E 2 GO:0008213 protein alkylation 2/502 181/18722 0.956965234594714 0.96857489792818 BTG2/KMT2E 2 GO:0007059 chromosome segregation 5/502 346/18722 0.957114840450394 0.96857489792818 RB1/ATM/DUSP1/PLSCR1/ACTR2 5 GO:0030326 embryonic limb morphogenesis 1/502 116/18722 0.95768732882047 0.96857489792818 MBNL1 1 GO:0031123 RNA 3'-end processing 1/502 116/18722 0.95768732882047 0.96857489792818 ZFP36L1 1 GO:0035113 embryonic appendage morphogenesis 1/502 116/18722 0.95768732882047 0.96857489792818 MBNL1 1 GO:0071824 protein-DNA complex subunit organization 3/502 241/18722 0.958599355274931 0.969285380874717 TCF4/RB1/ATF7IP 3 GO:0051225 spindle assembly 1/502 117/18722 0.958828947703203 0.969305662603806 HSPA1A 1 GO:0006413 translational initiation 1/502 118/18722 0.959939824792856 0.970216654903157 EIF4G3 1 GO:0031398 positive regulation of protein ubiquitination 1/502 119/18722 0.961020786304035 0.971097019974327 LAPTM5 1 GO:0048706 embryonic skeletal system development 1/502 121/18722 0.963096157232332 0.972981616806457 TGFBR2 1 GO:0072329 monocarboxylic acid catabolic process 1/502 122/18722 0.964092110625664 0.973775131824088 PLA2G15 1 GO:0099111 microtubule-based transport 2/502 190/18722 0.964977612238403 0.974254873420339 LAMP1/HIF1A 2 GO:0006325 chromatin organization 6/502 409/18722 0.964988290102031 0.974254873420339 RB1/ACTB/CHD9/BAZ2B/ATF7IP/KMT2E 6 GO:0060294 cilium movement involved in cell motility 1/502 125/18722 0.966921877259936 0.975921179838778 PLTP 1 GO:0022613 ribonucleoprotein complex biogenesis 7/502 463/18722 0.967060676260475 0.975921179838778 CELF2/ATM/GLUL/SETX/DDX17/SCAF11/ADAR 7 GO:1901605 alpha-amino acid metabolic process 2/502 195/18722 0.968788470234001 0.977382950069148 GLUL/GLS 2 GO:0006338 chromatin remodeling 3/502 255/18722 0.968931735628429 0.977382950069148 RB1/ACTB/BAZ2B 3 GO:0007127 meiosis I 1/502 129/18722 0.970351703024698 0.978601913710978 ATM 1 GO:0007098 centrosome cycle 1/502 130/18722 0.971152189502491 0.9791957342281 ATF5 1 GO:0018022 peptidyl-lysine methylation 1/502 131/18722 0.971931105211923 0.979767551255253 KMT2E 1 GO:0006997 nucleus organization 1/502 133/18722 0.973426529313666 0.981061247190636 RTN4 1 GO:0018205 peptidyl-lysine modification 5/502 376/18722 0.974775768700809 0.981846525315907 SPI1/EGR1/IFIH1/RANBP2/KMT2E 5 GO:0009581 detection of external stimulus 1/502 135/18722 0.974842432074353 0.981846525315907 ARRB2 1 GO:0061982 meiosis I cell cycle process 1/502 135/18722 0.974842432074353 0.981846525315907 ATM 1 GO:0001539 cilium or flagellum-dependent cell motility 1/502 138/18722 0.976826354953642 0.982561147644172 PLTP 1 GO:0009582 detection of abiotic stimulus 1/502 138/18722 0.976826354953642 0.982561147644172 ARRB2 1 GO:0035107 appendage morphogenesis 1/502 138/18722 0.976826354953642 0.982561147644172 MBNL1 1 GO:0035108 limb morphogenesis 1/502 138/18722 0.976826354953642 0.982561147644172 MBNL1 1 GO:0060285 cilium-dependent cell motility 1/502 138/18722 0.976826354953642 0.982561147644172 PLTP 1 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 1/502 138/18722 0.976826354953642 0.982561147644172 LAPTM5 1 GO:0016579 protein deubiquitination 1/502 139/18722 0.977452332666366 0.982977063242306 OTUD1 1 GO:0016571 histone methylation 1/502 141/18722 0.978654112887086 0.983971729236179 KMT2E 1 GO:0006865 amino acid transport 1/502 143/18722 0.979791959566434 0.984687726472805 SLC1A3 1 GO:0031023 microtubule organizing center organization 1/502 143/18722 0.979791959566434 0.984687726472805 ATF5 1 GO:0007281 germ cell development 3/502 278/18722 0.980808847251175 0.985495596738475 IGF1/QKI/FOXO3 3 GO:0060271 cilium assembly 4/502 337/18722 0.981244081710715 0.985718810422099 CCDC88A/EHD4/ACTR2/GSN 4 GO:0002181 cytoplasmic translation 1/502 148/18722 0.982378704823739 0.986644352695314 CPEB4 1 GO:0016573 histone acetylation 1/502 152/18722 0.984208003630042 0.988267033816491 SPI1 1 GO:0016570 histone modification 6/502 463/18722 0.986193684050695 0.989868044108411 SPI1/JAK2/ATM/DTX3L/JMJD1C/KMT2E 6 GO:0070646 protein modification by small protein removal 1/502 157/18722 0.986230396734904 0.989868044108411 OTUD1 1 GO:0018393 internal peptidyl-lysine acetylation 1/502 158/18722 0.986602728587264 0.990026946300366 SPI1 1 GO:0006475 internal protein amino acid acetylation 1/502 160/18722 0.987317517787036 0.990529350961359 SPI1 1 GO:0007286 spermatid development 1/502 165/18722 0.988942354935388 0.991944348207092 QKI 1 GO:0009451 RNA modification 1/502 167/18722 0.989532536748904 0.992321160849865 ADAR 1 GO:0044782 cilium organization 4/502 368/18722 0.989894960735864 0.992451192275555 CCDC88A/EHD4/ACTR2/GSN 4 GO:0018394 peptidyl-lysine acetylation 1/502 169/18722 0.990091278069971 0.992451192275555 SPI1 1 GO:0048515 spermatid differentiation 1/502 172/18722 0.990874071692422 0.99259061404269 QKI 1 GO:0048736 appendage development 1/502 172/18722 0.990874071692422 0.99259061404269 MBNL1 1 GO:0060173 limb development 1/502 172/18722 0.990874071692422 0.99259061404269 MBNL1 1 GO:0003341 cilium movement 1/502 175/18722 0.991595137674362 0.993097879818489 PLTP 1 GO:0007018 microtubule-based movement 4/502 382/18722 0.992404218460552 0.993693055107904 PLTP/ACTR2/LAMP1/HIF1A 4 GO:0071103 DNA conformation change 2/502 290/18722 0.996765889888072 0.997844407405804 CHD9/SETX 2 GO:0042254 ribosome biogenesis 2/502 299/18722 0.997406814766076 0.998269996777989 GLUL/DDX17 2 GO:0006364 rRNA processing 1/502 225/18722 0.997872390601796 0.998519939200499 DDX17 1 GO:0016072 rRNA metabolic process 1/502 236/18722 0.998428146883571 0.99878854286952 DDX17 1 GO:0034470 ncRNA processing 3/502 395/18722 0.998572635272704 0.99878854286952 STAT3/DDX17/ADAR 3 GO:0034660 ncRNA metabolic process 3/502 485/18722 0.999828427022077 0.999828427022077 STAT3/DDX17/ADAR 3