ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003697	single-stranded DNA binding	27/449	123/18367	1.81194713733324e-18	1.00929191017067e-15	RAD51/RAD51AP1/MCM10/BLM/CDC45/MCM6/HMGB2/MCM7/HMGB1/MSH2/SMC2/MCM3/RPA3/BRCA2/SMC4/MCM5/MCM4/POLA1/RPA2/SMC6/MCM2/NUCKS1/RPA1/NME1/HNRNPA2B1/YBX1/HSPD1	27
GO:0140097	catalytic activity, acting on DNA	35/449	229/18367	3.34202619261812e-18	1.00929191017067e-15	PCNA/HELLS/FEN1/RAD51/BLM/DSCC1/MCM6/TOP2A/LIG1/MCM7/UNG/RFC4/MSH2/RFC3/RFC2/ATAD5/MCM3/POLD3/MCM5/MCM4/POLA1/POLE2/SMC3/MSH6/RAD51C/RFC1/MCM2/XRCC5/RBBP4/MGMT/NME1/POLE3/RPS3/PTGES3/XRCC6	35
GO:0008094	ATP-dependent activity, acting on DNA	23/449	111/18367	2.45897732496571e-15	4.9507410142643e-13	HELLS/RAD51/BLM/DSCC1/MCM6/TOP2A/MCM7/RFC4/MSH2/RFC3/RFC2/ATAD5/MCM3/MCM5/MCM4/SMC3/MSH6/RAD51C/RFC1/MCM2/XRCC5/RBBP4/XRCC6	23
GO:0017116	single-stranded DNA helicase activity	11/449	23/18367	1.71311226545951e-12	2.58679952084386e-10	RAD51/DSCC1/MCM6/MCM7/RFC4/RFC3/RFC2/MCM3/MCM5/MCM4/MCM2	11
GO:0003684	damaged DNA binding	16/449	68/18367	5.71691126400376e-12	6.90602880691654e-10	PCNA/FEN1/BLM/BRCA1/HMGB2/UNG/HMGB1/MSH2/RPA3/MSH6/RPA2/SMC6/RPA1/XRCC5/RPS3/XRCC6	16
GO:0003678	DNA helicase activity	14/449	72/18367	1.82382707337149e-09	1.8359859205273e-07	RAD51/BLM/DSCC1/MCM6/MCM7/RFC4/RFC3/RFC2/MCM3/MCM5/MCM4/MCM2/XRCC5/XRCC6	14
GO:0000217	DNA secondary structure binding	10/449	36/18367	9.92448593542374e-09	8.56341357856563e-07	CLSPN/RAD51AP1/BLM/HMGB2/HMGB1/MSH2/MSH6/RAD51C/HNRNPD/HMGA1	10
GO:0070182	DNA polymerase binding	8/449	22/18367	2.83725227618006e-08	2.14212546851594e-06	PCNA/RAD51/CDT1/FANCI/HMGB1/FANCD2/HSP90AA1/PTGES3	8
GO:0003688	DNA replication origin binding	7/449	16/18367	4.70818663585346e-08	3.1597163645061e-06	CDC6/MCM10/CDC45/MCM5/POLA1/MCM2/HSPD1	7
GO:0042393	histone binding	22/449	244/18367	1.56921182261605e-07	9.47803940860093e-06	ATAD2/ASF1B/SAMD1/NASP/DNAJC9/VRK1/DEK/CKS1B/HAT1/NCAPD3/MSH6/CBX5/NAP1L1/ANP32B/MCM2/BAZ1B/YEATS4/RBBP4/SET/SSRP1/SUZ12/BRD7	22
GO:0000400	four-way junction DNA binding	6/449	17/18367	2.03228508447791e-06	0.000111590926456787	BLM/HMGB2/HMGB1/MSH2/MSH6/RAD51C	6
GO:0008022	protein C-terminus binding	17/449	189/18367	4.17847734132423e-06	0.000210316692846653	PCNA/MKI67/RAD51/MAD2L1/TOP2A/CENPF/MSH2/BRCA2/ID1/SAE1/YEATS4/TOPBP1/XRCC5/HRAS/DYNLT1/XRCC6/PHB2	17
GO:0004386	helicase activity	15/449	156/18367	6.81414515056275e-06	0.000316595666995377	HELLS/RAD51/BLM/DSCC1/MCM6/MCM7/RFC4/RFC3/RFC2/MCM3/MCM5/MCM4/MCM2/XRCC5/XRCC6	15
GO:0003735	structural constituent of ribosome	16/449	182/18367	1.06839839966044e-05	0.000460937595282075	RPL39L/RPS4Y1/RPS21/MRPL11/RPS2/RPS17/RPL35/RPS3/RPL3/RPL27A/MRPS34/MRPL17/RPS7/RPL7A/MRPL57/RPS5	16
GO:0042162	telomeric DNA binding	7/449	36/18367	2.24973933093714e-05	0.000905895037257355	BLM/RPA2/RPA1/XRCC5/HNRNPD/HNRNPA2B1/XRCC6	7
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	8/449	50/18367	2.61350712178946e-05	0.00098659893847552	CCNE2/CCNA2/CKS1B/CCNB2/CDK4/CDKN2A/CCNE1/CCND1	8
GO:0035173	histone kinase activity	5/449	16/18367	2.98454629567708e-05	0.00106039174269939	CDK1/CHEK1/VRK1/AURKB/BAZ1B	5
GO:0032356	oxidized DNA binding	4/449	10/18367	6.58358265423478e-05	0.00220915773508767	BLM/MSH2/MSH6/RPS3	4
GO:0047429	nucleoside-triphosphate diphosphatase activity	4/449	11/18367	0.000101460091210272	0.00322536289952655	DUT/DCTPP1/NUDT1/NUDT15	4
GO:0016835	carbon-oxygen lyase activity	9/449	79/18367	0.000130211468457029	0.00393238634740229	HACD3/XRCC5/FH/ECI1/ENO1/RPS3/TPI1/ECHS1/XRCC6	9
GO:0016829	lyase activity	14/449	196/18367	0.000343509404900494	0.00987998478856659	HMGB1/GGCT/HACD3/PAICS/TSEN34/XRCC5/FH/ECI1/DDT/ENO1/RPS3/TPI1/ECHS1/XRCC6	14
GO:0000287	magnesium ion binding	15/449	221/18367	0.000369173377572915	0.0101354872751837	FEN1/DUT/PRIM1/TOP2A/MSH2/PGP/NUDT8/MSH6/DCTPP1/MTHFD2/RAN/IDH2/ENO1/NME1/SRPK1	15
GO:0043138	3'-5' DNA helicase activity	4/449	15/18367	0.000388272167405117	0.01019636474403	BLM/MCM6/MCM5/MCM2	4
GO:0017070	U6 snRNA binding	4/449	16/18367	0.000507747735554566	0.0125365102254953	LSM4/LSM2/LSM3/LSM8	4
GO:0016853	isomerase activity	12/449	158/18367	0.000518895290790368	0.0125365102254953	TOP2A/PPIC/PPIA/PPIF/ECI1/DDT/PDIA6/TPI1/PTGES3/PDIA3/HSPD1/PGAM1	12
GO:0008301	DNA binding, bending	4/449	18/18367	0.000821230675857626	0.0185688035070515	HMGB2/TOP2A/HMGB1/TFAM	4
GO:0051082	unfolded protein binding	10/449	122/18367	0.000830062408427799	0.0185688035070515	CHAF1A/TUBB4B/PPIA/SRSF10/HSP90AA1/HSPA8/CCT5/PTGES3/HSPD1/LMAN1	10
GO:0015631	tubulin binding	20/449	375/18367	0.000979129945136372	0.021121231673656	PRC1/BRCA1/STMN1/BIRC5/NUSAP1/CENPF/KIF23/TPX2/BRCA2/KIF20B/GTSE1/SMC3/HAUS8/CENPJ/CACYBP/KIF22/SKA2/NME1/RPS3/CCT5	20
GO:0051087	chaperone binding	9/449	107/18367	0.00124519632561335	0.0259344338162229	BIRC5/DNAJC9/SDF2L1/HSPA8/DNAJC1/BAX/PTGES3/HSPD1/ERP29	9
GO:0045296	cadherin binding	18/449	332/18367	0.0014384449137752	0.0285508619605678	DIAPH3/RANBP1/TMPO/ANLN/NOP56/CCNB2/PAICS/SERBP1/RAN/CTNNAL1/RPS2/ENO1/HSPA8/PDLIM1/SNX5/RPL7A/RDX/LDHA	18
GO:0016860	intramolecular oxidoreductase activity	6/449	51/18367	0.00146535880923444	0.0285508619605678	ECI1/DDT/PDIA6/TPI1/PTGES3/PDIA3	6
GO:0098505	G-rich strand telomeric DNA binding	3/449	10/18367	0.00153210180526228	0.0289184215743256	RPA2/RPA1/HNRNPA2B1	3
GO:0031491	nucleosome binding	7/449	71/18367	0.00172064264849889	0.0306025045768914	VRK1/HMGN2/SUPT16H/PARP2/RBBP4/HMGN1/SSRP1	7
GO:0034061	DNA polymerase activity	5/449	36/18367	0.00172265754240779	0.0306025045768914	POLD3/POLA1/POLE2/POLE3/PTGES3	5
GO:0017069	snRNA binding	6/449	53/18367	0.00179299705192628	0.0309420062675279	LSM4/LSM2/LSM3/LSM8/SNRPA1/SNRPD3	6
GO:0032404	mismatch repair complex binding	3/449	11/18367	0.00206859244803179	0.0332647404540579	PCNA/MSH2/MSH6	3
GO:1990226	histone methyltransferase binding	3/449	11/18367	0.00206859244803179	0.0332647404540579	NOP56/CBX1/CBX3	3
GO:0044389	ubiquitin-like protein ligase binding	17/449	316/18367	0.00209281479677848	0.0332647404540579	UBE2T/BRCA1/UBE2C/TUBA1B/TUBB/RPA2/PA2G4/SMC6/CACYBP/JUN/SLC25A5/HSP90AA1/XRCC5/NAE1/HSPA8/TPI1/HSPD1	17
GO:0043047	single-stranded telomeric DNA binding	3/449	12/18367	0.00270837127622009	0.0416417911119036	RPA2/RPA1/HNRNPA2B1	3
GO:0031625	ubiquitin protein ligase binding	16/449	297/18367	0.0027577345107221	0.0416417911119036	UBE2T/BRCA1/TUBA1B/TUBB/RPA2/PA2G4/SMC6/CACYBP/JUN/SLC25A5/HSP90AA1/XRCC5/NAE1/HSPA8/TPI1/HSPD1	16
GO:0003887	DNA-directed DNA polymerase activity	4/449	25/18367	0.00296581803117727	0.0426512878769303	POLD3/POLA1/POLE2/POLE3	4
GO:0035925	mRNA 3'-UTR AU-rich region binding	4/449	25/18367	0.00296581803117727	0.0426512878769303	EXOSC9/EXOSC8/HNRNPD/ILF3	4
GO:0030983	mismatched DNA binding	3/449	14/18367	0.00432121499552832	0.0606979966813746	PCNA/MSH2/MSH6	3
GO:0019887	protein kinase regulator activity	12/449	204/18367	0.00451894958761907	0.0620328534300436	CCNE2/HMGB1/CCNA2/CKS1B/TPX2/CALM2/CCNB2/CDK4/DBF4/CDKN2A/CCNE1/CCND1	12
GO:0019207	kinase regulator activity	13/449	233/18367	0.0049747783147887	0.0653854739662389	CCNE2/HMGB1/CCNA2/CKS1B/TPX2/CALM2/CCNB2/CDK4/DBF4/CDKN2A/CCNE1/GSTP1/CCND1	13
GO:0016779	nucleotidyltransferase activity	9/449	132/18367	0.00517757918851158	0.0653854739662389	PRIM1/POLD3/POLA1/POLE2/POLR3K/POLR2L/POLE3/POLR2I/PTGES3	9
GO:0004549	tRNA-specific ribonuclease activity	3/449	15/18367	0.00530445070255912	0.0653854739662389	TSEN34/POP7/RPP30	3
GO:0098847	sequence-specific single stranded DNA binding	3/449	15/18367	0.00530445070255912	0.0653854739662389	RPA2/RPA1/HNRNPA2B1	3
GO:1990825	sequence-specific mRNA binding	3/449	15/18367	0.00530445070255912	0.0653854739662389	TYMS/DHFR/SRSF3	3
GO:0016887	ATP hydrolysis activity	14/449	272/18367	0.0073000080735469	0.0872990720234322	ATAD2/BLM/MCM6/MCM7/MCM3/KIF23/MCM5/MCM4/KIF20B/MCM2/KIF22/HSP90AA1/HSPA8/HSPD1	14
GO:0030515	snoRNA binding	4/449	32/18367	0.00737127926025669	0.0872990720234322	NOP56/PRKDC/NUDT1/XRCC5	4
GO:0004601	peroxidase activity	5/449	51/18367	0.00796452815521213	0.0925110578028486	PRDX2/GSTP1/GPX8/PRDX4/GPX1	5
GO:0000295	adenine nucleotide transmembrane transporter activity	3/449	18/18367	0.00901059474514291	0.100482929945218	SLC29A1/SLC25A5/SLC25A6	3
GO:0005346	purine ribonucleotide transmembrane transporter activity	3/449	18/18367	0.00901059474514291	0.100482929945218	SLC29A1/SLC25A5/SLC25A6	3
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	4/449	34/18367	0.00914993567381951	0.100482929945218	FEN1/RNASEH2A/POP7/RPP30	4
GO:0004129	cytochrome-c oxidase activity	3/449	19/18367	0.0105087777346697	0.113344674138224	CYB5A/COX5A/COX8A	3
GO:0003730	mRNA 3'-UTR binding	11/449	201/18367	0.0107423733683276	0.113490894842361	CARHSP1/FUS/EXOSC9/EXOSC8/SERBP1/HNRNPR/HNRNPD/HNRNPA2B1/ILF3/RPS7/CCT5	11
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/449	55/18367	0.010898132286187	0.113490894842361	PRDX2/GSTP1/GPX8/PRDX4/GPX1	5
GO:0043021	ribonucleoprotein complex binding	9/449	149/18367	0.0111099091853036	0.113735341490226	UNG/EZH2/SNRPD1/CBX5/SERBP1/SNRPG/SNRPB/NME1/C1QBP	9
GO:0140677	molecular function activator activity	9/449	150/18367	0.0115726290309775	0.11649779891184	PSMC3IP/CALM2/RFC1/DBF4/SAE1/XRCC5/ATP1B3/DNAJC1/SUZ12	9
GO:0016018	cyclosporin A binding	3/449	20/18367	0.0121425155541201	0.118291603140138	PPIC/PPIA/PPIF	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/449	20/18367	0.0121425155541201	0.118291603140138	CYB5A/COX5A/COX8A	3
GO:0015216	purine nucleotide transmembrane transporter activity	3/449	21/18367	0.0139136522646923	0.130193750051266	SLC29A1/SLC25A5/SLC25A6	3
GO:0140416	transcription regulator inhibitor activity	3/449	21/18367	0.0139136522646923	0.130193750051266	ID1/ID4/ID3	3
GO:0031072	heat shock protein binding	8/449	129/18367	0.0140109168101528	0.130193750051266	DNAJC9/TFAM/NUP62/KPNB1/HSPA8/RPS3/BAX/PTGES3	8
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	4/449	39/18367	0.0147537989319523	0.135019614468169	PRIM1/POLR3K/POLR2L/POLR2I	4
GO:0046982	protein heterodimerization activity	15/449	328/18367	0.0154550275695377	0.139325920179116	TOP2A/CENPW/BARD1/YWHAH/TCOF1/SMC3/RAN/SAE1/NAE1/PAFAH1B3/POLE3/LSM5/SMC1A/BAX/PHB2	15
GO:0004602	glutathione peroxidase activity	3/449	22/18367	0.0158236349068402	0.140551110054875	GSTP1/GPX8/GPX1	3
GO:0030331	estrogen receptor binding	4/449	41/18367	0.0174885156873825	0.15308787645187	PCNA/FUS/PARP1/PHB2	4
GO:0008047	enzyme activator activity	7/449	110/18367	0.0183979219575655	0.156511899469994	PSMC3IP/CALM2/RFC1/DBF4/SAE1/XRCC5/SUZ12	7
GO:0047485	protein N-terminus binding	7/449	110/18367	0.0183979219575655	0.156511899469994	ZWINT/ID1/CALM2/RPA2/PARP1/RPS21/PHB2	7
GO:0016209	antioxidant activity	6/449	86/18367	0.0187965483743667	0.157682155807188	PRDX2/GSTP1/GPX8/PRDX4/GSTO1/GPX1	6
GO:0016836	hydro-lyase activity	5/449	64/18367	0.0200093820473155	0.165249086397871	HACD3/FH/ECI1/ENO1/ECHS1	5
GO:0034062	5'-3' RNA polymerase activity	4/449	43/18367	0.0205193401984111	0.165249086397871	PRIM1/POLR3K/POLR2L/POLR2I	4
GO:0097747	RNA polymerase activity	4/449	43/18367	0.0205193401984111	0.165249086397871	PRIM1/POLR3K/POLR2L/POLR2I	4
GO:0051879	Hsp90 protein binding	4/449	44/18367	0.0221481980050536	0.173570627345127	NUP62/KPNB1/RPS3/PTGES3	4
GO:0004300	enoyl-CoA hydratase activity	2/449	10/18367	0.0235642242422193	0.173570627345127	ECI1/ECHS1	2
GO:0004523	RNA-DNA hybrid ribonuclease activity	2/449	10/18367	0.0235642242422193	0.173570627345127	FEN1/RNASEH2A	2
GO:0008641	ubiquitin-like modifier activating enzyme activity	2/449	10/18367	0.0235642242422193	0.173570627345127	SAE1/NAE1	2
GO:0033204	ribonuclease P RNA binding	2/449	10/18367	0.0235642242422193	0.173570627345127	POP7/RPP30	2
GO:0034511	U3 snoRNA binding	2/449	10/18367	0.0235642242422193	0.173570627345127	PRKDC/XRCC5	2
GO:0050786	RAGE receptor binding	2/449	10/18367	0.0235642242422193	0.173570627345127	HMGB2/HMGB1	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	4/449	45/18367	0.0238537868413619	0.17358659339979	FEN1/RNASEH2A/POP7/RPP30	4
GO:0030371	translation repressor activity	3/449	26/18367	0.0248683670793303	0.178815401379947	TYMS/DHFR/EIF4EBP1	3
GO:0004521	endoribonuclease activity	5/449	69/18367	0.0267438172507974	0.188109702305351	FEN1/RNASEH2A/TSEN34/POP7/RPP30	5
GO:0015215	nucleotide transmembrane transporter activity	3/449	27/18367	0.0274819894968213	0.188109702305351	SLC29A1/SLC25A5/SLC25A6	3
GO:0023026	MHC class II protein complex binding	3/449	27/18367	0.0274819894968213	0.188109702305351	HSP90AA1/HSPA8/CD81	3
GO:0048027	mRNA 5'-UTR binding	3/449	27/18367	0.0274819894968213	0.188109702305351	MYH10/RPS7/CCT5	3
GO:0005049	nuclear export signal receptor activity	2/449	11/18367	0.0283410313075943	0.188109702305351	RAN/CSE1L	2
GO:0005347	ATP transmembrane transporter activity	2/449	11/18367	0.0283410313075943	0.188109702305351	SLC25A5/SLC25A6	2
GO:0010485	H4 histone acetyltransferase activity	2/449	11/18367	0.0283410313075943	0.188109702305351	BRCA2/HAT1	2
GO:0003712	transcription coregulator activity	19/449	489/18367	0.032454779590914	0.211521679869172	GMNN/BRCA1/HMGB2/HMGB1/EZH2/PSMC3IP/FUS/PSIP1/PA2G4/CENPJ/CASP8AP2/SRSF2/NUCKS1/HMGA1/EID1/CCND1/PDLIM1/C1QBP/BRD7	19
GO:0004526	ribonuclease P activity	2/449	12/18367	0.0334675633138691	0.211521679869172	POP7/RPP30	2
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/449	12/18367	0.0334675633138691	0.211521679869172	CDK1/CDK4	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	4/449	50/18367	0.0335545600017231	0.211521679869172	SLC29A1/HNRNPA3/SLC25A5/SLC25A6	4
GO:0140297	DNA-binding transcription factor binding	16/449	394/18367	0.0336193398467558	0.211521679869172	PCNA/GMNN/HMGB1/CENPF/PTMA/YWHAH/FUS/EXOSC9/CBX5/PARP1/CDKN2A/JUN/CHCHD2/HMGA1/RPS3/PHB2	16
GO:0003725	double-stranded RNA binding	5/449	74/18367	0.0347720228691794	0.216467763837531	HMGB1/TUBA1B/TUBB4B/ILF3/HSPD1	5
GO:0008017	microtubule binding	12/449	271/18367	0.0351222530729769	0.216467763837531	PRC1/BIRC5/NUSAP1/CENPF/KIF23/TPX2/KIF20B/GTSE1/HAUS8/KIF22/SKA2/RPS3	12
GO:0022829	wide pore channel activity	3/449	30/18367	0.0361623976066005	0.220627153074613	TOMM40/VDAC3/VDAC1	3
GO:0042826	histone deacetylase binding	7/449	127/18367	0.03653120580692	0.220648483073797	GMNN/TOP2A/PARP1/HSP90AA1/HNRNPD/RBBP4/CCND1	7
GO:0140678	molecular function inhibitor activity	7/449	128/18367	0.0378683101000883	0.224121217309259	FBXO5/ID1/GCHFR/ID4/CALM2/ID3/RPS7	7
GO:0005542	folic acid binding	2/449	13/18367	0.038923947365876	0.224121217309259	TYMS/DHFR	2
GO:0019104	DNA N-glycosylase activity	2/449	13/18367	0.038923947365876	0.224121217309259	PCNA/UNG	2
GO:0004519	endonuclease activity	7/449	129/18367	0.0392371769281994	0.224121217309259	FEN1/RNASEH2A/RAD51C/TSEN34/POP7/RPP30/RPS3	7
GO:0043015	gamma-tubulin binding	3/449	31/18367	0.0393325315145389	0.224121217309259	BRCA2/CENPJ/NME1	3
GO:0140142	nucleocytoplasmic carrier activity	3/449	31/18367	0.0393325315145389	0.224121217309259	KPNB1/RAN/CSE1L	3
GO:0031490	chromatin DNA binding	6/449	103/18367	0.0406853437738964	0.227943563979094	EZH2/HMGN2/RBBP4/HMGN1/POLE3/SUZ12	6
GO:0003714	transcription corepressor activity	9/449	187/18367	0.0407581207114935	0.227943563979094	GMNN/EZH2/PA2G4/CASP8AP2/SRSF2/EID1/CCND1/C1QBP/BRD7	9
GO:0015605	organophosphate ester transmembrane transporter activity	3/449	32/18367	0.042638867954637	0.234126147678189	SLC29A1/SLC25A5/SLC25A6	3
GO:0030332	cyclin binding	3/449	32/18367	0.042638867954637	0.234126147678189	CDK1/CDK4/XRCC6	3
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	2/449	14/18367	0.0446910694276006	0.243183837245682	ECI1/DDT	2
GO:0005080	protein kinase C binding	4/449	55/18367	0.0452436957813776	0.243992787963858	TOP2A/HINT1/SRSF2/C1QBP	4
GO:0051287	NAD binding	4/449	56/18367	0.0478214597653502	0.255612050427182	HADH/PARP1/IDH2/LDHA	4
GO:0004536	deoxyribonuclease activity	4/449	57/18367	0.0504789432605878	0.267449839731535	FEN1/RAD51C/NME1/RPS3	4
GO:0032182	ubiquitin-like protein binding	6/449	111/18367	0.0549689356706796	0.283148951548502	TOP2A/CKS1B/NUP62/SERBP1/CASP8AP2/BUB3	6
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/449	16/18367	0.0570847159564488	0.283148951548502	TYMS/DHFR	2
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	2/449	16/18367	0.0570847159564488	0.283148951548502	RAD51C/TSEN34	2
GO:0032183	SUMO binding	2/449	16/18367	0.0570847159564488	0.283148951548502	SERBP1/CASP8AP2	2
GO:1990404	protein ADP-ribosylase activity	2/449	16/18367	0.0570847159564488	0.283148951548502	PARP1/PARP2	2
GO:0023023	MHC protein complex binding	3/449	36/18367	0.0571923378955583	0.283148951548502	HSP90AA1/HSPA8/CD81	3
GO:0061631	ubiquitin conjugating enzyme activity	3/449	36/18367	0.0571923378955583	0.283148951548502	UBE2T/UBE2C/UBE2S	3
GO:0097718	disordered domain specific binding	3/449	36/18367	0.0571923378955583	0.283148951548502	RRM1/CALM2/HSP90AA1	3
GO:0043531	ADP binding	3/449	37/18367	0.061152878613715	0.298144628917123	MSH2/MSH6/MYH10	3
GO:0003727	single-stranded RNA binding	5/449	87/18367	0.0620088273322143	0.298144628917123	HMGB1/HNRNPF/ILF3/HNRNPDL/KHDRBS1	5
GO:0008308	voltage-gated anion channel activity	2/449	17/18367	0.0636765846528292	0.298144628917123	VDAC3/VDAC1	2
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	2/449	17/18367	0.0636765846528292	0.298144628917123	CASP8AP2/CTSH	2
GO:0043024	ribosomal small subunit binding	2/449	17/18367	0.0636765846528292	0.298144628917123	UNG/NME1	2
GO:0046965	retinoid X receptor binding	2/449	17/18367	0.0636765846528292	0.298144628917123	FUS/HMGA1	2
GO:0070628	proteasome binding	2/449	17/18367	0.0636765846528292	0.298144628917123	ID1/PSMG1	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/449	38/18367	0.0652378626017597	0.298601028865666	PPIC/PPIA/PPIF	3
GO:0004520	endodeoxyribonuclease activity	3/449	38/18367	0.0652378626017597	0.298601028865666	FEN1/RAD51C/RPS3	3
GO:0004540	ribonuclease activity	6/449	116/18367	0.0652571784938211	0.298601028865666	FEN1/RNASEH2A/EXOSC9/TSEN34/POP7/RPP30	6
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/449	39/18367	0.069444867907577	0.315373685835914	UBE2T/UBE2C/UBE2S	3
GO:0004550	nucleoside diphosphate kinase activity	2/449	18/18367	0.0705098333912899	0.317820443047307	DTYMK/NME1	2
GO:0016407	acetyltransferase activity	5/449	91/18367	0.0722650541589037	0.320560487154907	ESCO2/ACAT2/BRCA2/HAT1/PAFAH1B3	5
GO:0004518	nuclease activity	9/449	210/18367	0.0735144632270813	0.320560487154907	FEN1/RNASEH2A/RAD51C/EXOSC9/TSEN34/POP7/RPP30/NME1/RPS3	9
GO:0031492	nucleosomal DNA binding	3/449	40/18367	0.0737713703882982	0.320560487154907	HMGN2/RBBP4/HMGN1	3
GO:0042287	MHC protein binding	3/449	40/18367	0.0737713703882982	0.320560487154907	TUBB/TUBB4B/CD81	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/449	40/18367	0.0737713703882982	0.320560487154907	BIRC5/CASP8AP2/CTSH	3
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	2/449	19/18367	0.0775687811155983	0.332688107092342	DHFR/MTHFD2	2
GO:0016859	cis-trans isomerase activity	3/449	41/18367	0.07821475365416	0.332688107092342	PPIC/PPIA/PPIF	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/449	41/18367	0.07821475365416	0.332688107092342	SAE1/SLC27A2/NAE1	3
GO:0015036	disulfide oxidoreductase activity	3/449	42/18367	0.0827723185046286	0.341674451810151	PDIA6/PDIA3/GSTO1	3
GO:0019205	nucleobase-containing compound kinase activity	3/449	42/18367	0.0827723185046286	0.341674451810151	TK1/DTYMK/NME1	3
GO:0003756	protein disulfide isomerase activity	2/449	20/18367	0.0848383661779847	0.341674451810151	PDIA6/PDIA3	2
GO:0016505	peptidase activator activity involved in apoptotic process	2/449	20/18367	0.0848383661779847	0.341674451810151	CASP8AP2/CTSH	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/449	20/18367	0.0848383661779847	0.341674451810151	PDIA6/PDIA3	2
GO:0031681	G-protein beta-subunit binding	2/449	20/18367	0.0848383661779847	0.341674451810151	CCT5/GNG5	2
GO:0042288	MHC class I protein binding	2/449	20/18367	0.0848383661779847	0.341674451810151	TUBB/TUBB4B	2
GO:0019843	rRNA binding	4/449	68/18367	0.0848529267740441	0.341674451810151	RPS4Y1/MRPL11/RPS3/RPS5	4
GO:0030544	Hsp70 protein binding	3/449	43/18367	0.0874412918775951	0.349765167510381	NUP62/RPS3/BAX	3
GO:0003777	microtubule motor activity	4/449	69/18367	0.0884288719754747	0.351282961516392	KIF23/KIF20B/SMC3/KIF22	4
GO:0009055	electron transfer activity	6/449	126/18367	0.0889839289933907	0.351282961516392	AKR7A2/ETFB/CYB5A/COX5A/COX8A/NDUFA4	6
GO:0004712	protein serine/threonine/tyrosine kinase activity	3/449	44/18367	0.0922188353316835	0.355106317353607	PBK/AURKB/TTK	3
GO:0005385	zinc ion transmembrane transporter activity	2/449	21/18367	0.0923041255372787	0.355106317353607	SLC39A1/SLC39A10	2
GO:0070577	lysine-acetylated histone binding	2/449	21/18367	0.0923041255372787	0.355106317353607	YEATS4/BRD7	2
GO:0140033	acetylation-dependent protein binding	2/449	21/18367	0.0923041255372787	0.355106317353607	YEATS4/BRD7	2
GO:0140030	modification-dependent protein binding	7/449	160/18367	0.0981501008548071	0.372661194188857	NCAPD3/MSH6/CBX5/YEATS4/SUZ12/HSPD1/BRD7	7
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	4/449	72/18367	0.0995824735948427	0.372661194188857	CYB5A/COX5A/COX8A/NDUFA4	4
GO:0005540	hyaluronic acid binding	2/449	22/18367	0.0999521746003225	0.372661194188857	HMMR/C1QBP	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/449	22/18367	0.0999521746003225	0.372661194188857	FBXO5/RPS7	2
GO:0070034	telomerase RNA binding	2/449	22/18367	0.0999521746003225	0.372661194188857	SNRPB/SNRPD3	2
GO:0030295	protein kinase activator activity	5/449	101/18367	0.101668131945013	0.3763678460528	HMGB1/CKS1B/TPX2/CALM2/DBF4	5
GO:0035064	methylated histone binding	4/449	73/18367	0.103438845107227	0.3763678460528	NCAPD3/MSH6/CBX5/SUZ12	4
GO:0140034	methylation-dependent protein binding	4/449	73/18367	0.103438845107227	0.3763678460528	NCAPD3/MSH6/CBX5/SUZ12	4
GO:0140104	molecular carrier activity	4/449	73/18367	0.103438845107227	0.3763678460528	KPNB1/RAN/HSPA8/CSE1L	4
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/449	23/18367	0.107769187687755	0.384321605065148	PARP1/PARP2	2
GO:0008143	poly(A) binding	2/449	23/18367	0.107769187687755	0.384321605065148	HNRNPDL/KHDRBS1	2
GO:0070412	R-SMAD binding	2/449	23/18367	0.107769187687755	0.384321605065148	PARP1/JUN	2
GO:0005200	structural constituent of cytoskeleton	5/449	103/18367	0.108169988180588	0.384321605065148	TUBA1B/TUBB/TUBB4B/TUBA1C/YEATS4	5
GO:0003713	transcription coactivator activity	10/449	262/18367	0.110392387614003	0.389923988999168	BRCA1/HMGB2/HMGB1/PSMC3IP/FUS/CENPJ/NUCKS1/HMGA1/PDLIM1/BRD7	10
GO:0043274	phospholipase binding	2/449	24/18367	0.115742379105788	0.404094780230613	LMNB1/SRSF3	2
GO:0070840	dynein complex binding	2/449	24/18367	0.115742379105788	0.404094780230613	CENPF/SMC3	2
GO:0016763	pentosyltransferase activity	3/449	49/18367	0.117632158805766	0.405998993821045	PARP1/PARP2/MTAP	3
GO:0043539	protein serine/threonine kinase activator activity	3/449	49/18367	0.117632158805766	0.405998993821045	CKS1B/CALM2/DBF4	3
GO:0019209	kinase activator activity	5/449	107/18367	0.121763076206339	0.417868738799026	HMGB1/CKS1B/TPX2/CALM2/DBF4	5
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	3/449	50/18367	0.122998814048578	0.41793926716705	PCNA/UNG/DNPH1	3
GO:0001221	transcription coregulator binding	4/449	78/18367	0.123709190669159	0.41793926716705	EZH2/TFAM/SUZ12/CBX3	4
GO:0035035	histone acetyltransferase binding	2/449	25/18367	0.123859484806129	0.41793926716705	PCNA/EID1	2
GO:0090079	translation regulator activity, nucleic acid binding	5/449	108/18367	0.125280675497321	0.420386266668789	TYMS/DHFR/EIF1AY/TUFM/EIF1AX	5
GO:0045182	translation regulator activity	6/449	140/18367	0.129017665185298	0.43053408713768	TYMS/DHFR/EIF1AY/EIF4EBP1/TUFM/EIF1AX	6
GO:0004364	glutathione transferase activity	2/449	26/18367	0.132108744616695	0.436031047805924	GSTP1/GSTO1	2
GO:0042974	retinoic acid receptor binding	2/449	26/18367	0.132108744616695	0.436031047805924	FUS/HMGA1	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/449	53/18367	0.13961130903632	0.456178744924066	SLC29A1/SLC25A5/SLC25A6	3
GO:0001671	ATPase activator activity	2/449	27/18367	0.140478885026285	0.456178744924066	ATP1B3/DNAJC1	2
GO:0022884	macromolecule transmembrane transporter activity	2/449	27/18367	0.140478885026285	0.456178744924066	HNRNPA3/TOMM40	2
GO:0016922	nuclear receptor binding	6/449	144/18367	0.141822505405841	0.458079108369669	PCNA/YWHAH/FUS/PARP1/HMGA1/PHB2	6
GO:0003774	cytoskeletal motor activity	5/449	114/18367	0.147338189519816	0.473363119521111	KIF23/KIF20B/SMC3/KIF22/MYH10	5
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2/449	29/18367	0.157539047357254	0.487967100532212	CDK1/CDK4	2
GO:0015301	anion:anion antiporter activity	2/449	29/18367	0.157539047357254	0.487967100532212	SLC25A5/SLC25A6	2
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	2/449	29/18367	0.157539047357254	0.487967100532212	DHFR/MTHFD2	2
GO:0046625	sphingolipid binding	2/449	29/18367	0.157539047357254	0.487967100532212	VDAC1/PHB2	2
GO:0051787	misfolded protein binding	2/449	29/18367	0.157539047357254	0.487967100532212	SDF2L1/HSPA8	2
GO:0070717	poly-purine tract binding	2/449	29/18367	0.157539047357254	0.487967100532212	HNRNPDL/KHDRBS1	2
GO:0097472	cyclin-dependent protein kinase activity	2/449	29/18367	0.157539047357254	0.487967100532212	CDK1/CDK4	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/449	57/18367	0.162841039698798	0.501816265194256	PDIA6/PDIA3/GSTO1	3
GO:0004197	cysteine-type endopeptidase activity	5/449	119/18367	0.166886734522099	0.511673033763186	USP1/CTSV/USP48/PDIA3/CTSH	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3/449	58/18367	0.168820593318099	0.514988072546119	FDPS/GSTP1/GSTO1	3
GO:0051117	ATPase binding	4/449	89/18367	0.173474079991685	0.523963724091176	SDF2L1/SVIP/ATP1B3/RDX	4
GO:0106310	protein serine kinase activity	12/449	360/18367	0.173497921884495	0.523963724091176	CDK1/PKMYT1/PBK/CHEK1/VRK1/MELK/MASTL/AURKB/TTK/PRKDC/CDK4/SRPK1	12
GO:0051020	GTPase binding	10/449	291/18367	0.177163086030771	0.532370666480526	DIAPH3/BIRC5/RANBP1/KPNB1/LSM2/NXT1/HSP90AA1/ENO1/CSE1L/YBX1	10
GO:0033218	amide binding	13/449	400/18367	0.183166503708424	0.544133626005881	TYMS/DHFR/DHCR24/KPNB1/PPIC/PPIA/PPIF/CTSV/DBI/ITM2C/VDAC1/PHB2/LRPAP1	13
GO:0001222	transcription corepressor binding	2/449	32/18367	0.183780231299999	0.544133626005881	EZH2/SUZ12	2
GO:0051721	protein phosphatase 2A binding	2/449	32/18367	0.183780231299999	0.544133626005881	MASTL/EIF4EBP1	2
GO:0004714	transmembrane receptor protein tyrosine kinase activity	5/449	124/18367	0.1873927418838	0.551512884070324	PBK/MELK/TTK/BAZ1B/EFEMP1	5
GO:0043130	ubiquitin binding	4/449	92/18367	0.188098765096832	0.551512884070324	TOP2A/CKS1B/NUP62/BUB3	4
GO:0001530	lipopolysaccharide binding	2/449	33/18367	0.192664127629149	0.557932963678716	HMGB1/HSPD1	2
GO:0140323	solute:anion antiporter activity	2/449	33/18367	0.192664127629149	0.557932963678716	SLC25A5/SLC25A6	2
GO:0072341	modified amino acid binding	4/449	93/18367	0.193059585113993	0.557932963678716	TYMS/DHFR/HMGB1/HSPA8	4
GO:0016831	carboxy-lyase activity	2/449	34/18367	0.201602279372671	0.577098467967267	PAICS/DDT	2
GO:0035198	miRNA binding	2/449	34/18367	0.201602279372671	0.577098467967267	HNRNPA2B1/YBX1	2
GO:0016874	ligase activity	6/449	165/18367	0.217525632110182	0.597497337143345	LIG1/GMPS/PAICS/SAE1/SLC27A2/NAE1	6
GO:0002039	p53 binding	3/449	66/18367	0.218661558827366	0.597497337143345	BLM/HSPD1/BRD7	3
GO:0008172	S-methyltransferase activity	1/449	10/18367	0.219296026249114	0.597497337143345	MGMT	1
GO:0008190	eukaryotic initiation factor 4E binding	1/449	10/18367	0.219296026249114	0.597497337143345	EIF4EBP1	1
GO:0016803	ether hydrolase activity	1/449	10/18367	0.219296026249114	0.597497337143345	AKR7A2	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/449	10/18367	0.219296026249114	0.597497337143345	PGAM1	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/449	10/18367	0.219296026249114	0.597497337143345	GMPS	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/449	10/18367	0.219296026249114	0.597497337143345	SLC27A2	1
GO:0048256	flap endonuclease activity	1/449	10/18367	0.219296026249114	0.597497337143345	FEN1	1
GO:0051880	G-quadruplex DNA binding	1/449	10/18367	0.219296026249114	0.597497337143345	BLM	1
GO:0042805	actinin binding	2/449	36/18367	0.219609948420236	0.597497337143345	CSRP2/PDLIM1	2
GO:0097110	scaffold protein binding	3/449	67/18367	0.225098059346702	0.606229472902399	TCOF1/HSP90AA1/XRCC6	3
GO:0015035	protein-disulfide reductase activity	2/449	37/18367	0.228664638123466	0.606229472902399	PDIA6/PDIA3	2
GO:0042056	chemoattractant activity	2/449	37/18367	0.228664638123466	0.606229472902399	HMGB2/HMGB1	2
GO:0046915	transition metal ion transmembrane transporter activity	2/449	37/18367	0.228664638123466	0.606229472902399	SLC39A1/SLC39A10	2
GO:0071949	FAD binding	2/449	37/18367	0.228664638123466	0.606229472902399	DHCR24/SQLE	2
GO:0008080	N-acetyltransferase activity	3/449	68/18367	0.231570911619286	0.606229472902399	ESCO2/BRCA2/HAT1	3
GO:0004674	protein serine/threonine kinase activity	12/449	386/18367	0.237371885678664	0.606229472902399	CDK1/PKMYT1/PBK/CHEK1/VRK1/MELK/MASTL/AURKB/TTK/PRKDC/CDK4/SRPK1	12
GO:0005436	sodium:phosphate symporter activity	1/449	11/18367	0.238391525743266	0.606229472902399	SLC20A1	1
GO:0008199	ferric iron binding	1/449	11/18367	0.238391525743266	0.606229472902399	RRM2	1
GO:0016801	hydrolase activity, acting on ether bonds	1/449	11/18367	0.238391525743266	0.606229472902399	AKR7A2	1
GO:0019855	calcium channel inhibitor activity	1/449	11/18367	0.238391525743266	0.606229472902399	CALM2	1
GO:0047676	arachidonate-CoA ligase activity	1/449	11/18367	0.238391525743266	0.606229472902399	SLC27A2	1
GO:0051400	BH domain binding	1/449	11/18367	0.238391525743266	0.606229472902399	BAX	1
GO:0070513	death domain binding	1/449	11/18367	0.238391525743266	0.606229472902399	BAX	1
GO:1990459	transferrin receptor binding	1/449	11/18367	0.238391525743266	0.606229472902399	CD81	1
GO:0004713	protein tyrosine kinase activity	5/449	136/18367	0.239882192092174	0.606229472902399	PBK/MELK/TTK/BAZ1B/EFEMP1	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	5/449	136/18367	0.239882192092174	0.606229472902399	HADH/AKR7A2/VKORC1/IDH2/LDHA	5
GO:0004857	enzyme inhibitor activity	3/449	70/18367	0.244614722878131	0.608786941299684	FBXO5/GCHFR/RPS7	3
GO:0004402	histone acetyltransferase activity	2/449	39/18367	0.246841148593614	0.608786941299684	BRCA2/HAT1	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/449	39/18367	0.246841148593614	0.608786941299684	DTYMK/NME1	2
GO:0050997	quaternary ammonium group binding	2/449	39/18367	0.246841148593614	0.608786941299684	DHTKD1/VDAC1	2
GO:0004177	aminopeptidase activity	2/449	40/18367	0.25595008428863	0.608786941299684	CTSV/CTSH	2
GO:0042169	SH2 domain binding	2/449	40/18367	0.25595008428863	0.608786941299684	NUP62/KHDRBS1	2
GO:0044183	protein folding chaperone	2/449	40/18367	0.25595008428863	0.608786941299684	HSPA8/CCT5	2
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/449	12/18367	0.257020976873211	0.608786941299684	RPS3	1
GO:0003964	RNA-directed DNA polymerase activity	1/449	12/18367	0.257020976873211	0.608786941299684	PTGES3	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/449	12/18367	0.257020976873211	0.608786941299684	AKR7A2	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/449	12/18367	0.257020976873211	0.608786941299684	CDKN2A	1
GO:0008429	phosphatidylethanolamine binding	1/449	12/18367	0.257020976873211	0.608786941299684	PEBP1	1
GO:0033130	acetylcholine receptor binding	1/449	12/18367	0.257020976873211	0.608786941299684	LY6E	1
GO:0034452	dynactin binding	1/449	12/18367	0.257020976873211	0.608786941299684	SNX5	1
GO:0042975	peroxisome proliferator activated receptor binding	1/449	12/18367	0.257020976873211	0.608786941299684	HMGA1	1
GO:0046790	virion binding	1/449	12/18367	0.257020976873211	0.608786941299684	PPIA	1
GO:0070063	RNA polymerase binding	3/449	73/18367	0.264385782458006	0.620217240733664	BRCA1/ANP32B/ZNF326	3
GO:0048487	beta-tubulin binding	2/449	41/18367	0.265064716628859	0.620217240733664	SMC3/CCT5	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/449	41/18367	0.265064716628859	0.620217240733664	BRCA2/HAT1	2
GO:0019199	transmembrane receptor protein kinase activity	5/449	143/18367	0.272167581098941	0.620217240733664	PBK/MELK/TTK/BAZ1B/EFEMP1	5
GO:0019894	kinesin binding	2/449	42/18367	0.274179336535071	0.620217240733664	PRC1/NUP62	2
GO:0008035	high-density lipoprotein particle binding	1/449	13/18367	0.275195729332156	0.620217240733664	HSPD1	1
GO:0008179	adenylate cyclase binding	1/449	13/18367	0.275195729332156	0.620217240733664	CALM2	1
GO:0016840	carbon-nitrogen lyase activity	1/449	13/18367	0.275195729332156	0.620217240733664	GGCT	1
GO:0031432	titin binding	1/449	13/18367	0.275195729332156	0.620217240733664	CALM2	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/449	13/18367	0.275195729332156	0.620217240733664	ANAPC11	1
GO:0042301	phosphate ion binding	1/449	13/18367	0.275195729332156	0.620217240733664	MTHFD2	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/449	13/18367	0.275195729332156	0.620217240733664	CKS1B	1
GO:0072542	protein phosphatase activator activity	1/449	13/18367	0.275195729332156	0.620217240733664	CALM2	1
GO:0005178	integrin binding	5/449	144/18367	0.276856252886462	0.621640062243209	HMGB1/TSPAN4/PPIA/EMP2/CD81	5
GO:0016504	peptidase activator activity	2/449	43/18367	0.283288509445192	0.631388412195188	CASP8AP2/CTSH	2
GO:0030547	signaling receptor inhibitor activity	2/449	43/18367	0.283288509445192	0.631388412195188	LY6E/LRPAP1	2
GO:0001618	virus receptor activity	3/449	76/18367	0.284341823874764	0.631406108898372	CDK1/SIVA1/CD81	3
GO:0140272	exogenous protein binding	3/449	77/18367	0.291023494948914	0.634149898345309	CDK1/SIVA1/CD81	3
GO:0017110	nucleoside-diphosphatase activity	1/449	14/18367	0.292926857017121	0.634149898345309	NUDT15	1
GO:0019992	diacylglycerol binding	1/449	14/18367	0.292926857017121	0.634149898345309	CHPT1	1
GO:0035259	glucocorticoid receptor binding	1/449	14/18367	0.292926857017121	0.634149898345309	YWHAH	1
GO:0044548	S100 protein binding	1/449	14/18367	0.292926857017121	0.634149898345309	CACYBP	1
GO:0071837	HMG box domain binding	1/449	14/18367	0.292926857017121	0.634149898345309	JUN	1
GO:0140666	annealing activity	1/449	14/18367	0.292926857017121	0.634149898345309	BLM	1
GO:0030674	protein-macromolecule adaptor activity	9/449	296/18367	0.299998920749717	0.644542537825436	POLD3/TCOF1/COL14A1/CBX5/NUP62/ATP1B3/HSPA8/AP2S1/KHDRBS1	9
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2/449	45/18367	0.301470089182073	0.644542537825436	MELK/BAZ1B	2
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	9/449	299/18367	0.31006215243415	0.644542537825436	PCNA/YWHAH/FUS/EXOSC9/PARP1/CDKN2A/JUN/HMGA1/PHB2	9
GO:0001846	opsonin binding	1/449	15/18367	0.310225164716098	0.644542537825436	C1QBP	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/449	15/18367	0.310225164716098	0.644542537825436	SLC27A2	1
GO:0010851	cyclase regulator activity	1/449	15/18367	0.310225164716098	0.644542537825436	CALM2	1
GO:0019215	intermediate filament binding	1/449	15/18367	0.310225164716098	0.644542537825436	NME1	1
GO:0030548	acetylcholine receptor regulator activity	1/449	15/18367	0.310225164716098	0.644542537825436	LY6E	1
GO:0032794	GTPase activating protein binding	1/449	15/18367	0.310225164716098	0.644542537825436	TUBB	1
GO:0051371	muscle alpha-actinin binding	1/449	15/18367	0.310225164716098	0.644542537825436	PDLIM1	1
GO:0099602	neurotransmitter receptor regulator activity	1/449	15/18367	0.310225164716098	0.644542537825436	LY6E	1
GO:0061980	regulatory RNA binding	2/449	46/18367	0.310532911435765	0.644542537825436	HNRNPA2B1/YBX1	2
GO:0008234	cysteine-type peptidase activity	6/449	190/18367	0.320850648713305	0.660766292838055	USP1/GGH/CTSV/USP48/PDIA3/CTSH	6
GO:0005092	GDP-dissociation inhibitor activity	1/449	16/18367	0.327101194633408	0.660766292838055	RANBP1	1
GO:0005159	insulin-like growth factor receptor binding	1/449	16/18367	0.327101194633408	0.660766292838055	YWHAH	1
GO:0005521	lamin binding	1/449	16/18367	0.327101194633408	0.660766292838055	TMPO	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/449	16/18367	0.327101194633408	0.660766292838055	FEN1	1
GO:0035497	cAMP response element binding	1/449	16/18367	0.327101194633408	0.660766292838055	JUN	1
GO:0070402	NADPH binding	1/449	16/18367	0.327101194633408	0.660766292838055	DHFR	1
GO:0070403	NAD+ binding	1/449	16/18367	0.327101194633408	0.660766292838055	HADH	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/449	48/18367	0.328580447381641	0.661541967395037	GMPS/PAICS	2
GO:0022853	active ion transmembrane transporter activity	8/449	267/18367	0.32979226705935	0.66177584486328	SLC25A5/ATP1B3/SLC25A1/SLC20A1/CYB5A/SLC25A6/COX5A/COX8A	8
GO:0032813	tumor necrosis factor receptor superfamily binding	2/449	49/18367	0.337556970299763	0.66298211049631	SIVA1/CASP8AP2	2
GO:0034212	peptide N-acetyltransferase activity	2/449	49/18367	0.337556970299763	0.66298211049631	BRCA2/HAT1	2
GO:0008135	translation factor activity, RNA binding	3/449	84/18367	0.337976118128074	0.66298211049631	EIF1AY/TUFM/EIF1AX	3
GO:0004659	prenyltransferase activity	1/449	17/18367	0.343565232757194	0.66298211049631	FDPS	1
GO:0005324	long-chain fatty acid transporter activity	1/449	17/18367	0.343565232757194	0.66298211049631	SLC27A2	1
GO:0008574	plus-end-directed microtubule motor activity	1/449	17/18367	0.343565232757194	0.66298211049631	KIF20B	1
GO:0031489	myosin V binding	1/449	17/18367	0.343565232757194	0.66298211049631	FUS	1
GO:0032393	MHC class I receptor activity	1/449	17/18367	0.343565232757194	0.66298211049631	CTSH	1
GO:0034185	apolipoprotein binding	1/449	17/18367	0.343565232757194	0.66298211049631	HSPD1	1
GO:0050780	dopamine receptor binding	1/449	17/18367	0.343565232757194	0.66298211049631	SNX5	1
GO:0052745	inositol phosphate phosphatase activity	1/449	17/18367	0.343565232757194	0.66298211049631	IMPA2	1
GO:0070064	proline-rich region binding	1/449	17/18367	0.343565232757194	0.66298211049631	CCND1	1
GO:0015485	cholesterol binding	2/449	50/18367	0.346496893476896	0.666509947961927	CD81/VDAC1	2
GO:0003743	translation initiation factor activity	2/449	51/18367	0.355396645752042	0.670854008108505	EIF1AY/EIF1AX	2
GO:0051018	protein kinase A binding	2/449	51/18367	0.355396645752042	0.670854008108505	RPS3/RDX	2
GO:0004708	MAP kinase kinase activity	1/449	18/18367	0.359627315072836	0.670854008108505	PBK	1
GO:0008409	5'-3' exonuclease activity	1/449	18/18367	0.359627315072836	0.670854008108505	FEN1	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/449	18/18367	0.359627315072836	0.670854008108505	MARVELD3	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/449	18/18367	0.359627315072836	0.670854008108505	AKR7A2	1
GO:0048038	quinone binding	1/449	18/18367	0.359627315072836	0.670854008108505	VKORC1	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/449	18/18367	0.359627315072836	0.670854008108505	PDLIM1	1
GO:0140597	protein carrier activity	1/449	18/18367	0.359627315072836	0.670854008108505	HSPA8	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4/449	124/18367	0.359862083819794	0.670854008108505	HADH/AKR7A2/IDH2/LDHA	4
GO:0016830	carbon-carbon lyase activity	2/449	52/18367	0.364252851630654	0.676949915030508	PAICS/DDT	2
GO:0003746	translation elongation factor activity	1/449	19/18367	0.375297233626015	0.68690766397004	TUFM	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/449	19/18367	0.375297233626015	0.68690766397004	SLC29A1	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/449	19/18367	0.375297233626015	0.68690766397004	SNX5	1
GO:0035613	RNA stem-loop binding	1/449	19/18367	0.375297233626015	0.68690766397004	MYH10	1
GO:0035615	clathrin adaptor activity	1/449	19/18367	0.375297233626015	0.68690766397004	AP2S1	1
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/449	20/18367	0.390584542439069	0.693861951862347	EZH2	1
GO:0004551	nucleotide diphosphatase activity	1/449	20/18367	0.390584542439069	0.693861951862347	NUDT15	1
GO:0016408	C-acyltransferase activity	1/449	20/18367	0.390584542439069	0.693861951862347	ACAT2	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/449	20/18367	0.390584542439069	0.693861951862347	CHPT1	1
GO:0019211	phosphatase activator activity	1/449	20/18367	0.390584542439069	0.693861951862347	CALM2	1
GO:0031690	adrenergic receptor binding	1/449	20/18367	0.390584542439069	0.693861951862347	C1QBP	1
GO:0050145	nucleoside monophosphate kinase activity	1/449	20/18367	0.390584542439069	0.693861951862347	DTYMK	1
GO:0061608	nuclear import signal receptor activity	1/449	20/18367	0.390584542439069	0.693861951862347	KPNB1	1
GO:0097001	ceramide binding	1/449	20/18367	0.390584542439069	0.693861951862347	VDAC1	1
GO:0140312	cargo adaptor activity	1/449	20/18367	0.390584542439069	0.693861951862347	AP2S1	1
GO:0015078	proton transmembrane transporter activity	4/449	130/18367	0.393181188626223	0.696426504194248	SLC25A5/CYB5A/COX5A/COX8A	4
GO:0030374	nuclear receptor coactivator activity	2/449	56/18367	0.39918114222702	0.702931224213178	PSMC3IP/HMGA1	2
GO:0042054	histone methyltransferase activity	2/449	56/18367	0.39918114222702	0.702931224213178	EZH2/SUZ12	2
GO:0016410	N-acyltransferase activity	3/449	94/18367	0.404571133011733	0.70379635696446	ESCO2/BRCA2/HAT1	3
GO:0001848	complement binding	1/449	21/18367	0.405498563284159	0.70379635696446	C1QBP	1
GO:0005123	death receptor binding	1/449	21/18367	0.405498563284159	0.70379635696446	CASP8AP2	1
GO:0015662	P-type ion transporter activity	1/449	21/18367	0.405498563284159	0.70379635696446	ATP1B3	1
GO:0140358	P-type transmembrane transporter activity	1/449	21/18367	0.405498563284159	0.70379635696446	ATP1B3	1
GO:0060090	molecular adaptor activity	10/449	369/18367	0.415320765952944	0.707893329019911	POLD3/TCOF1/COL14A1/CBX5/NUP62/PSMG1/ATP1B3/HSPA8/AP2S1/KHDRBS1	10
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/449	58/18367	0.416309425432622	0.707893329019911	SLC27A2/MPC2	2
GO:0000062	fatty-acyl-CoA binding	1/449	22/18367	0.420048391316723	0.707893329019911	DBI	1
GO:0005537	mannose binding	1/449	22/18367	0.420048391316723	0.707893329019911	LMAN1	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/449	22/18367	0.420048391316723	0.707893329019911	AKR7A2	1
GO:0008320	protein transmembrane transporter activity	1/449	22/18367	0.420048391316723	0.707893329019911	TOMM40	1
GO:0015645	fatty acid ligase activity	1/449	22/18367	0.420048391316723	0.707893329019911	SLC27A2	1
GO:0016881	acid-amino acid ligase activity	1/449	22/18367	0.420048391316723	0.707893329019911	PAICS	1
GO:0030742	GTP-dependent protein binding	1/449	22/18367	0.420048391316723	0.707893329019911	GCHFR	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/449	22/18367	0.420048391316723	0.707893329019911	BIRC5	1
GO:0043177	organic acid binding	4/449	135/18367	0.420751167414152	0.707893329019911	TYMS/DHFR/GCHFR/ID3	4
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/449	59/18367	0.424781235422014	0.708872194448219	FEN1/EXOSC9	2
GO:0036002	pre-mRNA binding	2/449	59/18367	0.424781235422014	0.708872194448219	SLBP/SRSF2	2
GO:0008168	methyltransferase activity	6/449	214/18367	0.425287805106202	0.708872194448219	TYMS/EZH2/COMTD1/GCSH/MGMT/SUZ12	6
GO:0004867	serine-type endopeptidase inhibitor activity	3/449	98/18367	0.430709130355865	0.708872194448219	PEBP1/SPINT2/APLP2	3
GO:0001786	phosphatidylserine binding	2/449	60/18367	0.433188700874286	0.708872194448219	HMGB1/HSPA8	2
GO:0032934	sterol binding	2/449	60/18367	0.433188700874286	0.708872194448219	CD81/VDAC1	2
GO:0004529	exodeoxyribonuclease activity	1/449	23/18367	0.434242900572585	0.708872194448219	FEN1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/449	23/18367	0.434242900572585	0.708872194448219	FEN1	1
GO:0017134	fibroblast growth factor binding	1/449	23/18367	0.434242900572585	0.708872194448219	RPS2	1
GO:0050750	low-density lipoprotein particle receptor binding	1/449	23/18367	0.434242900572585	0.708872194448219	LRPAP1	1
GO:1901567	fatty acid derivative binding	1/449	23/18367	0.434242900572585	0.708872194448219	DBI	1
GO:0003924	GTPase activity	9/449	337/18367	0.441360819571352	0.718549690083818	TUBA1B/TUBB/TUBB4B/RAN/TUBA1C/GPN3/HRAS/TUFM/GNG5	9
GO:0031267	small GTPase binding	7/449	259/18367	0.447788732221204	0.725594671840575	DIAPH3/BIRC5/RANBP1/KPNB1/LSM2/NXT1/CSE1L	7
GO:0008171	O-methyltransferase activity	1/449	24/18367	0.448090749332011	0.725594671840575	COMTD1	1
GO:1990841	promoter-specific chromatin binding	2/449	62/18367	0.449803051590976	0.726419901499866	EZH2/RBL1	2
GO:0015399	primary active transmembrane transporter activity	5/449	181/18367	0.454938304424138	0.732753962325812	ATP1B3/CYB5A/COX5A/COX8A/NDUFA4	5
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	6/449	222/18367	0.459867593976671	0.735570279543565	ESCO2/ACAT2/BRCA2/HAT1/ZDHHC12/PAFAH1B3	6
GO:0008266	poly(U) RNA binding	1/449	25/18367	0.461600385353922	0.735570279543565	KHDRBS1	1
GO:0008327	methyl-CpG binding	1/449	25/18367	0.461600385353922	0.735570279543565	ERH	1
GO:0120227	acyl-CoA binding	1/449	25/18367	0.461600385353922	0.735570279543565	DBI	1
GO:0008238	exopeptidase activity	3/449	103/18367	0.462776003686349	0.735570279543565	GGH/CTSV/CTSH	3
GO:0140098	catalytic activity, acting on RNA	10/449	386/18367	0.471139314746775	0.738128015200679	FEN1/PRIM1/RNASEH2A/POLR3K/EXOSC9/TSEN34/POP7/RPP30/POLR2L/POLR2I	10
GO:1901681	sulfur compound binding	7/449	265/18367	0.471497165425695	0.738128015200679	DHTKD1/PPIA/GSTP1/DBI/APLP2/LRPAP1/CCDC80	7
GO:0016741	transferase activity, transferring one-carbon groups	6/449	225/18367	0.472710161802078	0.738128015200679	TYMS/EZH2/COMTD1/GCSH/MGMT/SUZ12	6
GO:0008514	organic anion transmembrane transporter activity	5/449	185/18367	0.473869979915946	0.738128015200679	SLC29A1/SLC25A5/SLC25A1/MPC2/SLC25A6	5
GO:0030145	manganese ion binding	2/449	65/18367	0.474198178184677	0.738128015200679	FEN1/NUDT8	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/449	26/18367	0.474780050983411	0.738128015200679	ZDHHC12	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/449	26/18367	0.474780050983411	0.738128015200679	ZDHHC12	1
GO:0097602	cullin family protein binding	1/449	26/18367	0.474780050983411	0.738128015200679	ANAPC11	1
GO:1990782	protein tyrosine kinase binding	3/449	105/18367	0.475383771379245	0.738128015200679	PCNA/HSP90AA1/KHDRBS1	3
GO:0043022	ribosome binding	2/449	66/18367	0.482183697539593	0.744112294748704	SERBP1/C1QBP	2
GO:0008139	nuclear localization sequence binding	1/449	27/18367	0.487637788135609	0.744112294748704	KPNB1	1
GO:0016405	CoA-ligase activity	1/449	27/18367	0.487637788135609	0.744112294748704	SLC27A2	1
GO:0016866	intramolecular transferase activity	1/449	27/18367	0.487637788135609	0.744112294748704	PGAM1	1
GO:0035255	ionotropic glutamate receptor binding	1/449	27/18367	0.487637788135609	0.744112294748704	FUS	1
GO:0051393	alpha-actinin binding	1/449	27/18367	0.487637788135609	0.744112294748704	PDLIM1	1
GO:0005539	glycosaminoglycan binding	6/449	230/18367	0.493917203048929	0.744112294748704	HMMR/PPIA/C1QBP/APLP2/LRPAP1/CCDC80	6
GO:0061134	peptidase regulator activity	6/449	230/18367	0.493917203048929	0.744112294748704	BIRC5/CASP8AP2/PEBP1/SPINT2/APLP2/CTSH	6
GO:0051536	iron-sulfur cluster binding	2/449	68/18367	0.497928058603434	0.744112294748704	POLA1/RPS3	2
GO:0051540	metal cluster binding	2/449	68/18367	0.497928058603434	0.744112294748704	POLA1/RPS3	2
GO:0001968	fibronectin binding	1/449	28/18367	0.500181443158897	0.744112294748704	CCDC80	1
GO:0004629	phospholipase C activity	1/449	28/18367	0.500181443158897	0.744112294748704	PDIA3	1
GO:0008187	poly-pyrimidine tract binding	1/449	28/18367	0.500181443158897	0.744112294748704	KHDRBS1	1
GO:0015101	organic cation transmembrane transporter activity	1/449	28/18367	0.500181443158897	0.744112294748704	SLC29A1	1
GO:0017056	structural constituent of nuclear pore	1/449	28/18367	0.500181443158897	0.744112294748704	NUP62	1
GO:0070325	lipoprotein particle receptor binding	1/449	28/18367	0.500181443158897	0.744112294748704	LRPAP1	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/449	28/18367	0.500181443158897	0.744112294748704	SNX5	1
GO:0004033	aldo-keto reductase (NADP) activity	1/449	29/18367	0.512418671580384	0.754880189352566	AKR7A2	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/449	29/18367	0.512418671580384	0.754880189352566	DHCR24	1
GO:0051059	NF-kappaB binding	1/449	29/18367	0.512418671580384	0.754880189352566	CDKN2A	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/449	29/18367	0.512418671580384	0.754880189352566	SNX5	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/449	71/18367	0.52096283480927	0.761755625298735	HINT1/HINT2	2
GO:0016417	S-acyltransferase activity	1/449	30/18367	0.524356942736476	0.761755625298735	ZDHHC12	1
GO:0017147	Wnt-protein binding	1/449	30/18367	0.524356942736476	0.761755625298735	WLS	1
GO:0046966	thyroid hormone receptor binding	1/449	30/18367	0.524356942736476	0.761755625298735	FUS	1
GO:0042277	peptide binding	8/449	321/18367	0.528046417379738	0.761755625298735	DHCR24/KPNB1/PPIC/PPIA/PPIF/CTSV/ITM2C/LRPAP1	8
GO:0030276	clathrin binding	2/449	72/18367	0.528482586525001	0.761755625298735	NSG1/AP2S1	2
GO:0106306	protein serine phosphatase activity	2/449	73/18367	0.535921933118438	0.761755625298735	PPM1G/CTDSPL	2
GO:0106307	protein threonine phosphatase activity	2/449	73/18367	0.535921933118438	0.761755625298735	PPM1G/CTDSPL	2
GO:0000146	microfilament motor activity	1/449	31/18367	0.536003544291328	0.761755625298735	MYH10	1
GO:0005164	tumor necrosis factor receptor binding	1/449	31/18367	0.536003544291328	0.761755625298735	SIVA1	1
GO:0016878	acid-thiol ligase activity	1/449	31/18367	0.536003544291328	0.761755625298735	SLC27A2	1
GO:0031210	phosphatidylcholine binding	1/449	31/18367	0.536003544291328	0.761755625298735	VDAC1	1
GO:0071813	lipoprotein particle binding	1/449	31/18367	0.536003544291328	0.761755625298735	HSPD1	1
GO:0071814	protein-lipid complex binding	1/449	31/18367	0.536003544291328	0.761755625298735	HSPD1	1
GO:0140318	protein transporter activity	1/449	31/18367	0.536003544291328	0.761755625298735	TOMM40	1
GO:0001223	transcription coactivator binding	1/449	32/18367	0.547365586645887	0.770649916862741	TFAM	1
GO:0048019	receptor antagonist activity	1/449	32/18367	0.547365586645887	0.770649916862741	LRPAP1	1
GO:0050699	WW domain binding	1/449	32/18367	0.547365586645887	0.770649916862741	KIF20B	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/449	32/18367	0.547365586645887	0.770649916862741	HELLS	1
GO:0019003	GDP binding	2/449	75/18367	0.550557206415664	0.773340820174561	RAN/HRAS	2
GO:0005154	epidermal growth factor receptor binding	1/449	33/18367	0.55845000724016	0.777197705928702	EFEMP1	1
GO:0008200	ion channel inhibitor activity	1/449	33/18367	0.55845000724016	0.777197705928702	CALM2	1
GO:0019956	chemokine binding	1/449	33/18367	0.55845000724016	0.777197705928702	HMGB1	1
GO:0031369	translation initiation factor binding	1/449	33/18367	0.55845000724016	0.777197705928702	EIF4EBP1	1
GO:0016248	channel inhibitor activity	1/449	34/18367	0.569263574751296	0.786808236040693	CALM2	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/449	34/18367	0.569263574751296	0.786808236040693	CDKN2A	1
GO:0045505	dynein intermediate chain binding	1/449	34/18367	0.569263574751296	0.786808236040693	DYNLT1	1
GO:0016746	acyltransferase activity	6/449	250/18367	0.575419052429694	0.792504245149052	ESCO2/ACAT2/BRCA2/HAT1/ZDHHC12/PAFAH1B3	6
GO:0005525	GTP binding	9/449	377/18367	0.576008880166281	0.792504245149052	TUBA1B/TUBB/TUBB4B/RAN/TUBA1C/GPN3/NME1/HRAS/TUFM	9
GO:0046332	SMAD binding	2/449	79/18367	0.578842696751026	0.794120153031195	PARP1/JUN	2
GO:0000175	3'-5'-exoribonuclease activity	1/449	35/18367	0.579812893189995	0.794120153031195	EXOSC9	1
GO:0004527	exonuclease activity	2/449	80/18367	0.585707257304446	0.800378243013315	FEN1/EXOSC9	2
GO:0140101	catalytic activity, acting on a tRNA	3/449	124/18367	0.587383808444694	0.800857382168386	TSEN34/POP7/RPP30	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/449	36/18367	0.590104405897703	0.800950699240927	MTHFD2	1
GO:0042605	peptide antigen binding	1/449	36/18367	0.590104405897703	0.800950699240927	DHCR24	1
GO:0035591	signaling adaptor activity	2/449	81/18367	0.592488792518187	0.801065910994559	NUP62/KHDRBS1	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/449	125/18367	0.592841824858556	0.801065910994559	HINT1/MTHFD2/HINT2	3
GO:0008242	omega peptidase activity	3/449	126/18367	0.59825297624985	0.806573209051137	USP1/GGH/USP48	3
GO:0016409	palmitoyltransferase activity	1/449	37/18367	0.600144399446987	0.807321196583475	ZDHHC12	1
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	1/449	38/18367	0.60993900744744	0.816446647640732	EXOSC9	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/449	38/18367	0.60993900744744	0.816446647640732	RPS3	1
GO:0001540	amyloid-beta binding	2/449	84/18367	0.612334985730549	0.816446647640732	ITM2C/LRPAP1	2
GO:0030165	PDZ domain binding	2/449	84/18367	0.612334985730549	0.816446647640732	CADM1/GNG5	2
GO:0050660	flavin adenine dinucleotide binding	2/449	85/18367	0.618784409433202	0.82236155035751	DHCR24/SQLE	2
GO:0005504	fatty acid binding	1/449	39/18367	0.619494214259383	0.82236155035751	GSTP1	1
GO:0003925	G protein activity	1/449	40/18367	0.628815858617607	0.82766057029731	HRAS	1
GO:0004532	exoribonuclease activity	1/449	40/18367	0.628815858617607	0.82766057029731	EXOSC9	1
GO:0017080	sodium channel regulator activity	1/449	40/18367	0.628815858617607	0.82766057029731	YWHAH	1
GO:0005253	anion channel activity	2/449	87/18367	0.631435075204842	0.82766057029731	VDAC3/VDAC1	2
GO:0044325	transmembrane transporter binding	3/449	133/18367	0.634797010212709	0.82766057029731	YWHAH/CALM2/VDAC1	3
GO:0008276	protein methyltransferase activity	2/449	88/18367	0.637636726123526	0.82766057029731	EZH2/SUZ12	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	1/449	41/18367	0.637909637167326	0.82766057029731	COL14A1	1
GO:0019001	guanyl nucleotide binding	9/449	398/18367	0.640698930215405	0.82766057029731	TUBA1B/TUBB/TUBB4B/RAN/TUBA1C/GPN3/NME1/HRAS/TUFM	9
GO:0032561	guanyl ribonucleotide binding	9/449	398/18367	0.640698930215405	0.82766057029731	TUBA1B/TUBB/TUBB4B/RAN/TUBA1C/GPN3/NME1/HRAS/TUFM	9
GO:0015297	antiporter activity	2/449	89/18367	0.643756260221139	0.82766057029731	SLC25A5/SLC25A6	2
GO:0019888	protein phosphatase regulator activity	2/449	89/18367	0.643756260221139	0.82766057029731	CALM2/SET	2
GO:0043178	alcohol binding	2/449	89/18367	0.643756260221139	0.82766057029731	CD81/VDAC1	2
GO:0004866	endopeptidase inhibitor activity	4/449	180/18367	0.644818022562426	0.82766057029731	BIRC5/PEBP1/SPINT2/APLP2	4
GO:0001046	core promoter sequence-specific DNA binding	1/449	42/18367	0.646781107914454	0.82766057029731	EZH2	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1/449	42/18367	0.646781107914454	0.82766057029731	NDUFA4	1
GO:0008307	structural constituent of muscle	1/449	42/18367	0.646781107914454	0.82766057029731	CSRP2	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/449	42/18367	0.646781107914454	0.82766057029731	POLA1	1
GO:0008509	anion transmembrane transporter activity	7/449	314/18367	0.650118658984587	0.828207445459718	SLC29A1/SLC25A5/SLC25A1/MPC2/VDAC3/SLC25A6/VDAC1	7
GO:0005246	calcium channel regulator activity	1/449	43/18367	0.655435693592294	0.828207445459718	CALM2	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/449	43/18367	0.655435693592294	0.828207445459718	SQLE	1
GO:0016790	thiolester hydrolase activity	1/449	43/18367	0.655435693592294	0.828207445459718	PNKD	1
GO:0018024	histone-lysine N-methyltransferase activity	1/449	43/18367	0.655435693592294	0.828207445459718	EZH2	1
GO:0050136	NADH dehydrogenase (quinone) activity	1/449	43/18367	0.655435693592294	0.828207445459718	NDUFA4	1
GO:0022804	active transmembrane transporter activity	9/449	406/18367	0.663865036788539	0.835380678557856	SLC25A5/ATP1B3/SLC25A1/SLC20A1/CYB5A/SLC25A6/COX5A/COX8A/NDUFA4	9
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/449	44/18367	0.663878684946641	0.835380678557856	DHTKD1	1
GO:0003954	NADH dehydrogenase activity	1/449	45/18367	0.67211524394129	0.840491940663643	NDUFA4	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/449	45/18367	0.67211524394129	0.840491940663643	NDUFA4	1
GO:0048156	tau protein binding	1/449	45/18367	0.67211524394129	0.840491940663643	HSP90AA1	1
GO:0030414	peptidase inhibitor activity	4/449	187/18367	0.674128279736148	0.841267522645936	BIRC5/PEBP1/SPINT2/APLP2	4
GO:0004864	protein phosphatase inhibitor activity	1/449	46/18367	0.680150406885857	0.84703267166816	SET	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3/449	144/18367	0.687415608445054	0.851527477136543	PCNA/UNG/DNPH1	3
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/449	47/18367	0.687989087487803	0.851527477136543	ATP1B3	1
GO:0035254	glutamate receptor binding	1/449	47/18367	0.687989087487803	0.851527477136543	FUS	1
GO:0004722	protein serine/threonine phosphatase activity	2/449	98/18367	0.695196717292055	0.858688787820861	PPM1G/CTDSPL	2
GO:0061135	endopeptidase regulator activity	4/449	194/18367	0.701725670026819	0.859851005151818	BIRC5/PEBP1/SPINT2/APLP2	4
GO:0008009	chemokine activity	1/449	49/18367	0.703096061279044	0.859851005151818	CKLF	1
GO:0019212	phosphatase inhibitor activity	1/449	49/18367	0.703096061279044	0.859851005151818	SET	1
GO:0098632	cell-cell adhesion mediator activity	1/449	49/18367	0.703096061279044	0.859851005151818	PDLIM1	1
GO:0019842	vitamin binding	3/449	148/18367	0.70508606169322	0.859851005151818	TYMS/DHFR/DHTKD1	3
GO:0005496	steroid binding	2/449	100/18367	0.705759343543762	0.859851005151818	CD81/VDAC1	2
GO:0019902	phosphatase binding	4/449	196/18367	0.709294275252022	0.859851005151818	MASTL/CARHSP1/RPA2/EIF4EBP1	4
GO:0000993	RNA polymerase II complex binding	1/449	50/18367	0.710373595315823	0.859851005151818	ZNF326	1
GO:0005048	signal sequence binding	1/449	50/18367	0.710373595315823	0.859851005151818	KPNB1	1
GO:0030159	signaling receptor complex adaptor activity	1/449	50/18367	0.710373595315823	0.859851005151818	NUP62	1
GO:0019903	protein phosphatase binding	3/449	150/18367	0.713631023591696	0.862066276498769	MASTL/RPA2/EIF4EBP1	3
GO:0016597	amino acid binding	1/449	52/18367	0.724399022202715	0.873327364092694	GCHFR	1
GO:0050661	NADP binding	1/449	53/18367	0.731155497170281	0.879716972690936	DHFR	1
GO:0004842	ubiquitin-protein transferase activity	9/449	433/18367	0.735297182092541	0.882941347880507	DTL/UBE2T/BRCA1/UBE2C/BARD1/HERC5/UBE2S/ANAPC11/KLHL42	9
GO:0008408	3'-5' exonuclease activity	1/449	54/18367	0.737746694165506	0.884125006499932	EXOSC9	1
GO:0019208	phosphatase regulator activity	2/449	107/18367	0.740347536440657	0.885484974277538	CALM2/SET	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	1/449	56/18367	0.750449292989543	0.895793227204909	BIRC5	1
GO:0003779	actin binding	9/449	440/18367	0.752039901644877	0.895921302945771	DIAPH3/YWHAH/ANLN/CTNNAL1/RUSC1/ARPC5L/MYH10/PDLIM1/RDX	9
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/449	57/18367	0.756568470939829	0.897774767087734	NDUFA4	1
GO:0043175	RNA polymerase core enzyme binding	1/449	57/18367	0.756568470939829	0.897774767087734	ZNF326	1
GO:0046943	carboxylic acid transmembrane transporter activity	3/449	163/18367	0.764562507659253	0.90289929329415	SLC27A2/SLC25A1/MPC2	3
GO:0004843	thiol-dependent deubiquitinase	2/449	113/18367	0.767175163378389	0.90289929329415	USP1/USP48	2
GO:0005342	organic acid transmembrane transporter activity	3/449	164/18367	0.768157647502446	0.90289929329415	SLC27A2/SLC25A1/MPC2	3
GO:0016279	protein-lysine N-methyltransferase activity	1/449	59/18367	0.768361319127803	0.90289929329415	EZH2	1
GO:0098631	cell adhesion mediator activity	1/449	59/18367	0.768361319127803	0.90289929329415	PDLIM1	1
GO:0101005	deubiquitinase activity	2/449	114/18367	0.77140487686857	0.903917308220763	USP1/USP48	2
GO:0016278	lysine N-methyltransferase activity	1/449	60/18367	0.774042210962608	0.903917308220763	EZH2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/449	60/18367	0.774042210962608	0.903917308220763	DHCR24	1
GO:0008201	heparin binding	3/449	166/18367	0.775213850427741	0.903917308220763	APLP2/LRPAP1/CCDC80	3
GO:0043621	protein self-association	1/449	61/18367	0.779584082775455	0.907261630050819	SVIP	1
GO:0019787	ubiquitin-like protein transferase activity	9/449	458/18367	0.791677320465017	0.919563656847828	DTL/UBE2T/BRCA1/UBE2C/BARD1/HERC5/UBE2S/ANAPC11/KLHL42	9
GO:0005201	extracellular matrix structural constituent	3/449	172/18367	0.795331531243086	0.922035018945919	COL14A1/VWA1/EFEMP1	3
GO:0004252	serine-type endopeptidase activity	3/449	174/18367	0.801695540901014	0.925858712627557	CTSV/SEC11A/CTSH	3
GO:0004721	phosphoprotein phosphatase activity	3/449	174/18367	0.801695540901014	0.925858712627557	PGP/PPM1G/CTDSPL	3
GO:0031406	carboxylic acid binding	3/449	176/18367	0.807893005526082	0.93123544911785	TYMS/DHFR/GSTP1	3
GO:0019783	ubiquitin-like protein-specific protease activity	2/449	125/18367	0.813670065753369	0.936108037552448	USP1/USP48	2
GO:0005518	collagen binding	1/449	69/18367	0.819304818703835	0.940525911212732	COL14A1	1
GO:0001098	basal transcription machinery binding	1/449	70/18367	0.823738753363469	0.940525911212732	ZNF326	1
GO:0001099	basal RNA polymerase II transcription machinery binding	1/449	70/18367	0.823738753363469	0.940525911212732	ZNF326	1
GO:0004860	protein kinase inhibitor activity	1/449	70/18367	0.823738753363469	0.940525911212732	CDKN2A	1
GO:0048029	monosaccharide binding	1/449	71/18367	0.828064123628529	0.943680623908738	LMAN1	1
GO:0017124	SH3 domain binding	2/449	130/18367	0.830469649508615	0.944639676653867	KHDRBS1/GPX1	2
GO:0042379	chemokine receptor binding	1/449	72/18367	0.832283581897592	0.944923465161928	CKLF	1
GO:0015370	solute:sodium symporter activity	1/449	73/18367	0.836399715908414	0.946040128106146	SLC20A1	1
GO:0033293	monocarboxylic acid binding	1/449	73/18367	0.836399715908414	0.946040128106146	GSTP1	1
GO:0017022	myosin binding	1/449	74/18367	0.840415050310793	0.946691314624186	FUS	1
GO:0019210	kinase inhibitor activity	1/449	74/18367	0.840415050310793	0.946691314624186	CDKN2A	1
GO:0015291	secondary active transmembrane transporter activity	4/449	240/18367	0.841677542968854	0.946691314624186	SLC25A5/SLC25A1/SLC20A1/SLC25A6	4
GO:0008236	serine-type peptidase activity	3/449	191/18367	0.849347884204688	0.953491445266706	CTSV/SEC11A/CTSH	3
GO:0001664	G protein-coupled receptor binding	5/449	295/18367	0.85088061092509	0.953491445266706	CKLF/HSPA8/SNX5/WLS/C1QBP	5
GO:0030971	receptor tyrosine kinase binding	1/449	78/18367	0.855516761660436	0.956911340820192	PCNA	1
GO:0099106	ion channel regulator activity	2/449	139/18367	0.857303443777415	0.957137301370718	YWHAH/CALM2	2
GO:0017171	serine hydrolase activity	3/449	195/18367	0.859000552000817	0.957262607764748	CTSV/SEC11A/CTSH	3
GO:0005244	voltage-gated ion channel activity	3/449	201/18367	0.872464402170018	0.967483605476642	TMEM109/VDAC3/VDAC1	3
GO:0022832	voltage-gated channel activity	3/449	201/18367	0.872464402170018	0.967483605476642	TMEM109/VDAC3/VDAC1	3
GO:0016247	channel regulator activity	2/449	145/18367	0.872977756597301	0.967483605476642	YWHAH/CALM2	2
GO:0042562	hormone binding	1/449	86/18367	0.881575966426219	0.975223230259041	CTSH	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/449	88/18367	0.88732191311073	0.975706318676927	NDUFA4	1
GO:0048306	calcium-dependent protein binding	1/449	88/18367	0.88732191311073	0.975706318676927	CALM2	1
GO:0015081	sodium ion transmembrane transporter activity	2/449	152/18367	0.889255851971368	0.975706318676927	ATP1B3/SLC20A1	2
GO:0015103	inorganic anion transmembrane transporter activity	2/449	152/18367	0.889255851971368	0.975706318676927	VDAC3/VDAC1	2
GO:0008081	phosphoric diester hydrolase activity	1/449	89/18367	0.890089704620839	0.975706318676927	PDIA3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/449	156/18367	0.897667912975302	0.982230832313555	EZH2/COMTD1	2
GO:0005126	cytokine receptor binding	4/449	271/18367	0.901024444539232	0.984120731467805	SIVA1/CKLF/CASP8AP2/DDT	4
GO:0051015	actin filament binding	3/449	217/18367	0.902965367653475	0.984460436936279	CTNNAL1/ARPC5L/MYH10	3
GO:0016791	phosphatase activity	4/449	275/18367	0.907045387533206	0.987126872198299	PGP/IMPA2/PPM1G/CTDSPL	4
GO:0008170	N-methyltransferase activity	1/449	97/18367	0.909924203369714	0.988478810854869	EZH2	1
GO:0004497	monooxygenase activity	1/449	102/18367	0.920462902978765	0.9951738601553	SQLE	1
GO:0004725	protein tyrosine phosphatase activity	1/449	102/18367	0.920462902978765	0.9951738601553	PGP	1
GO:0003823	antigen binding	2/449	171/18367	0.924192320933055	0.9951738601553	DHCR24/TSPAN4	2
GO:0004620	phospholipase activity	1/449	104/18367	0.924325389978681	0.9951738601553	PDIA3	1
GO:0015294	solute:cation symporter activity	1/449	104/18367	0.924325389978681	0.9951738601553	SLC20A1	1
GO:1902936	phosphatidylinositol bisphosphate binding	1/449	107/18367	0.929771016917181	0.999255683661882	SNX5	1
GO:0042626	ATPase-coupled transmembrane transporter activity	1/449	109/18367	0.933182404790985	0.999758445546463	ATP1B3	1
GO:0042578	phosphoric ester hydrolase activity	5/449	366/18367	0.947009326807087	0.999758445546463	PGP/IMPA2/PPM1G/CTDSPL/PDIA3	5
GO:0004175	endopeptidase activity	6/449	430/18367	0.953758822035301	0.999758445546463	USP1/CTSV/SEC11A/USP48/PDIA3/CTSH	6
GO:0005516	calmodulin binding	2/449	201/18367	0.959037094491177	0.999758445546463	ASPM/MYH10	2
GO:0016298	lipase activity	1/449	129/18367	0.959402112261691	0.999758445546463	PDIA3	1
GO:0016757	glycosyltransferase activity	3/449	270/18367	0.962681087561561	0.999758445546463	PARP1/PARP2/MTAP	3
GO:0002020	protease binding	1/449	135/18367	0.965042500237072	0.999758445546463	BRCA2	1
GO:0019955	cytokine binding	1/449	139/18367	0.968361227947805	0.999758445546463	HMGB1	1
GO:0020037	heme binding	1/449	139/18367	0.968361227947805	0.999758445546463	CYB5A	1
GO:0019838	growth factor binding	1/449	141/18367	0.969900752517088	0.999758445546463	RPS2	1
GO:0070851	growth factor receptor binding	1/449	141/18367	0.969900752517088	0.999758445546463	EFEMP1	1
GO:0015293	symporter activity	1/449	144/18367	0.972071015075865	0.999758445546463	SLC20A1	1
GO:0140375	immune receptor activity	1/449	144/18367	0.972071015075865	0.999758445546463	CTSH	1
GO:0005543	phospholipid binding	6/449	466/18367	0.973196101791829	0.999758445546463	HMGB1/NUP62/HSPA8/SNX5/PEBP1/VDAC1	6
GO:0052689	carboxylic ester hydrolase activity	1/449	147/18367	0.974085117306805	0.999758445546463	PAFAH1B3	1
GO:0046906	tetrapyrrole binding	1/449	149/18367	0.975346667476862	0.999758445546463	CYB5A	1
GO:0005506	iron ion binding	1/449	151/18367	0.976546934831255	0.999758445546463	RRM2	1
GO:0005319	lipid transporter activity	1/449	154/18367	0.978238889369764	0.999758445546463	SLC27A2	1
GO:0015079	potassium ion transmembrane transporter activity	1/449	155/18367	0.978775359949733	0.999758445546463	ATP1B3	1
GO:0005125	cytokine activity	2/449	235/18367	0.980017467127233	0.999758445546463	HMGB1/CKLF	2
GO:0061630	ubiquitin protein ligase activity	3/449	304/18367	0.980437105243364	0.999758445546463	UBE2C/HERC5/ANAPC11	3
GO:0008083	growth factor activity	1/449	162/18367	0.982178740605643	0.999758445546463	EFEMP1	1
GO:0061659	ubiquitin-like protein ligase activity	3/449	316/18367	0.984503600212359	0.999758445546463	UBE2C/HERC5/ANAPC11	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/449	170/18367	0.985406578692001	0.999758445546463	SQLE	1
GO:1901981	phosphatidylinositol phosphate binding	1/449	173/18367	0.986460451446968	0.999758445546463	SNX5	1
GO:0022836	gated channel activity	3/449	340/18367	0.990344735498625	0.999758445546463	TMEM109/VDAC3/VDAC1	3
GO:0030246	carbohydrate binding	2/449	271/18367	0.990826216045708	0.999758445546463	MLEC/LMAN1	2
GO:0015267	channel activity	5/449	480/18367	0.992046836452066	0.999758445546463	TOMM40/TMEM109/BAX/VDAC3/VDAC1	5
GO:0022803	passive transmembrane transporter activity	5/449	481/18367	0.992185944270963	0.999758445546463	TOMM40/TMEM109/BAX/VDAC3/VDAC1	5
GO:0016758	hexosyltransferase activity	1/449	197/18367	0.992570067677148	0.999758445546463	MTAP	1
GO:0048018	receptor ligand activity	5/449	487/18367	0.992973205879189	0.999758445546463	HMGB2/HMGB1/CKLF/EFEMP1/LRPAP1	5
GO:0046873	metal ion transmembrane transporter activity	4/449	430/18367	0.993824886005104	0.999758445546463	ATP1B3/SLC20A1/SLC39A1/SLC39A10	4
GO:0030546	signaling receptor activator activity	5/449	495/18367	0.993906026723159	0.999758445546463	HMGB2/HMGB1/CKLF/EFEMP1/LRPAP1	5
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	2/449	310/18367	0.996120213640038	0.999758445546463	JUN/ENO1	2
GO:0001217	DNA-binding transcription repressor activity	2/449	313/18367	0.996371058670869	0.999758445546463	JUN/ENO1	2
GO:0035091	phosphatidylinositol binding	1/449	271/18367	0.99883799307223	0.999758445546463	SNX5	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	3/449	450/18367	0.998998405936898	0.999758445546463	MYBL2/JUN/TFDP1	3
GO:0001216	DNA-binding transcription activator activity	3/449	456/18367	0.999118223119265	0.999758445546463	MYBL2/JUN/TFDP1	3
GO:0005096	GTPase activator activity	3/449	462/18367	0.999223970021354	0.999758445546463	RANBP1/HACD3/JUN	3
GO:0030695	GTPase regulator activity	3/449	488/18367	0.999555540470325	0.999758445546463	RANBP1/HACD3/JUN	3
GO:0060589	nucleoside-triphosphatase regulator activity	3/449	488/18367	0.999555540470325	0.999758445546463	RANBP1/HACD3/JUN	3
GO:0005216	ion channel activity	2/449	432/18367	0.999758445546463	0.999758445546463	VDAC3/VDAC1	2