ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0006260 DNA replication 67/436 260/18722 7.1388068707796e-51 2.44932463736448e-47 PCNA/FEN1/CDK1/CDC6/GINS2/RAD51/RRM2/DTL/MCM10/FAM111B/BLM/CCNE2/ESCO2/RRM1/ORC6/CDC45/DUT/DSCC1/MCM6/GMNN/PRIM1/CDT1/LIG1/MCM7/FBXO5/CHEK1/RFC4/NASP/CCNA2/RFC3/CHAF1A/RFC2/ATAD5/RNASEH2A/MCM3/POLD3/RPA3/BRCA2/MCM5/MCM4/MMS22L/POLA1/RMI2/POLE2/SMC3/TIPIN/RPA2/SUPT16H/RFC1/NAP1L1/ID3/CACYBP/POLD2/DBF4/JUN/MCM2/NUCKS1/RPA1/MCMBP/TOPBP1/CCNE1/RBBP4/SET/POLE3/HMGA1/SSRP1/HRAS 67 GO:0006261 DNA-dependent DNA replication 40/436 151/18722 4.6813018584299e-31 6.01437361694795e-28 PCNA/FEN1/CDC6/RAD51/MCM10/BLM/CCNE2/ORC6/CDC45/DSCC1/MCM6/GMNN/PRIM1/CDT1/LIG1/MCM7/FBXO5/RFC4/RFC3/RFC2/MCM3/POLD3/BRCA2/MCM5/MCM4/MMS22L/POLA1/POLE2/TIPIN/RFC1/POLD2/DBF4/MCM2/NUCKS1/RPA1/MCMBP/TOPBP1/CCNE1/POLE3/HMGA1 40 GO:0007059 chromosome segregation 56/436 346/18722 5.25885189473735e-31 6.01437361694795e-28 MKI67/FEN1/CDC6/CDCA5/CCNE2/ESCO2/MAD2L1/SPC25/PRC1/DSCC1/BRCA1/ZWINT/CDT1/NUF2/TOP2A/CENPW/FBXO5/NCAPH/UBE2C/BIRC5/CENPN/NUSAP1/CENPF/NDC80/CENPK/SMC2/PSMC3IP/KIF23/SKA3/CENPH/SMC4/NCAPG/AURKB/FANCD2/RMI2/SMC3/NCAPD3/TTK/RAD51C/NUP62/KPNB1/SMC6/RAN/BUB3/MCMBP/KIF22/SLC25A5/CCNE1/SKA2/DSN1/ANAPC11/RPS3/SRPK1/SMC1A/RAD21/PHB2 56 GO:0000819 sister chromatid segregation 39/436 202/18722 9.58922766291418e-25 8.22516002786463e-22 FEN1/CDC6/CDCA5/ESCO2/MAD2L1/PRC1/DSCC1/ZWINT/CDT1/NUF2/TOP2A/FBXO5/NCAPH/UBE2C/NUSAP1/CENPF/NDC80/CENPK/SMC2/KIF23/SMC4/NCAPG/AURKB/RMI2/SMC3/NCAPD3/TTK/RAD51C/NUP62/KPNB1/RAN/BUB3/MCMBP/KIF22/DSN1/ANAPC11/SMC1A/RAD21/PHB2 39 GO:0000280 nuclear division 54/436 439/18722 6.31395368356247e-24 4.33263501766056e-21 MKI67/CDC6/RAD51/RAD51AP1/CDCA5/PKMYT1/CCNE2/MAD2L1/MYBL2/PRC1/DSCC1/MND1/ZWINT/CDT1/NUF2/TOP2A/FBXO5/NCAPH/UBE2C/CHEK1/NUSAP1/CENPF/NDC80/CENPK/SMC2/PSMC3IP/KIF23/TPX2/BRCA2/RANBP1/SMC4/NCAPG/AURKB/ANLN/KIF20B/FANCD2/SMC3/NCAPD3/TTK/ASPM/RAD51C/UBE2S/NUP62/KPNB1/CCNB2/RAN/BUB3/KIF22/CCNE1/DSN1/ANAPC11/SMC1A/RAD21/PHB2 54 GO:0006302 double-strand break repair 41/436 251/18722 4.76773257582645e-23 2.4736071827752e-20 FEN1/GINS2/RAD51/RAD51AP1/CDCA5/BLM/ESCO2/CDC45/MCM6/BRCA1/HMGB2/MCM7/HMGB1/CHEK1/MSH2/DEK/MCM3/RPA3/BRCA2/FOXM1/MCM5/MCM4/MMS22L/POLA1/FUS/FANCD2/RMI2/PRKDC/RAD51C/RPA2/SMC6/PARP1/PARP2/MCM2/NUCKS1/RPA1/XRCC5/MGMT/RIF1/XRCC6/RAD21 41 GO:0044772 mitotic cell cycle phase transition 52/436 424/18722 5.29700595725027e-23 2.4736071827752e-20 CLSPN/CDK1/CDC6/DTL/CDCA5/BLM/PKMYT1/CCNE2/MAD2L1/BRCA1/ZWINT/CDT1/FBXO5/UBE2C/CHEK1/CENPF/NDC80/NASP/CCNA2/EZH2/MELK/FOXM1/MASTL/AURKB/ANLN/GTSE1/TTK/CALM2/PRKDC/RAD51C/RPA2/UBE2S/CCNB2/CDK4/RBL1/DBF4/CDKN2A/EIF4EBP1/RNASEH2B/BUB3/TOPBP1/CCNE1/NAE1/TFDP1/ANAPC11/CCND1/CTDSPL/RDX/RAD21/KHDRBS1/BRD7/PHB2 52 GO:0098813 nuclear chromosome segregation 43/436 281/18722 5.76766466400512e-23 2.4736071827752e-20 FEN1/CDC6/CDCA5/CCNE2/ESCO2/MAD2L1/PRC1/DSCC1/ZWINT/CDT1/NUF2/TOP2A/FBXO5/NCAPH/UBE2C/NUSAP1/CENPF/NDC80/CENPK/SMC2/PSMC3IP/KIF23/SMC4/NCAPG/AURKB/FANCD2/RMI2/SMC3/NCAPD3/TTK/RAD51C/NUP62/KPNB1/RAN/BUB3/MCMBP/KIF22/CCNE1/DSN1/ANAPC11/SMC1A/RAD21/PHB2 43 GO:0048285 organelle fission 54/436 488/18722 9.91013078229795e-22 3.7638570055762e-19 MKI67/CDC6/RAD51/RAD51AP1/CDCA5/PKMYT1/CCNE2/MAD2L1/MYBL2/PRC1/DSCC1/MND1/ZWINT/CDT1/NUF2/TOP2A/FBXO5/NCAPH/UBE2C/CHEK1/NUSAP1/CENPF/NDC80/CENPK/SMC2/PSMC3IP/KIF23/TPX2/BRCA2/RANBP1/SMC4/NCAPG/AURKB/ANLN/KIF20B/FANCD2/SMC3/NCAPD3/TTK/ASPM/RAD51C/UBE2S/NUP62/KPNB1/CCNB2/RAN/BUB3/KIF22/CCNE1/DSN1/ANAPC11/SMC1A/RAD21/PHB2 54 GO:0140014 mitotic nuclear division 42/436 287/18722 1.09701457463603e-21 3.7638570055762e-19 MKI67/CDC6/CDCA5/PKMYT1/MAD2L1/MYBL2/PRC1/DSCC1/ZWINT/CDT1/NUF2/FBXO5/NCAPH/UBE2C/CHEK1/NUSAP1/CENPF/NDC80/CENPK/SMC2/KIF23/TPX2/RANBP1/SMC4/NCAPG/AURKB/ANLN/KIF20B/SMC3/NCAPD3/TTK/UBE2S/NUP62/KPNB1/RAN/BUB3/KIF22/DSN1/ANAPC11/SMC1A/RAD21/PHB2 42 GO:0000070 mitotic sister chromatid segregation 32/436 168/18722 2.62099699672174e-20 8.17512790522937e-18 CDC6/CDCA5/MAD2L1/PRC1/DSCC1/ZWINT/CDT1/NUF2/FBXO5/NCAPH/UBE2C/NUSAP1/CENPF/NDC80/CENPK/SMC2/KIF23/SMC4/NCAPG/AURKB/SMC3/NCAPD3/TTK/NUP62/KPNB1/RAN/BUB3/KIF22/DSN1/ANAPC11/SMC1A/RAD21 32 GO:0006310 DNA recombination 41/436 305/18722 8.57457033960221e-20 2.45161256959793e-17 FEN1/GINS2/RAD51/RAD51AP1/BLM/CDC45/MND1/MCM6/BRCA1/HMGB2/TOP2A/MCM7/UNG/HMGB1/CHEK1/MSH2/PSMC3IP/MCM3/RPA3/BRCA2/MCM5/MCM4/MMS22L/FUS/FANCD2/RMI2/MSH6/PRKDC/RAD51C/RPA2/SMC6/PARP1/MCM2/NUCKS1/RPA1/XRCC5/TPRKB/RIF1/XRCC6/RAD21/HSPD1 41 GO:0071103 DNA conformation change 40/436 290/18722 9.57804968632993e-20 2.52786834413831e-17 HELLS/CDK1/RAD51/ASF1B/CDCA5/BLM/DSCC1/MCM6/HMGB2/TOP2A/MCM7/CENPW/NCAPH/HMGB1/NUSAP1/RFC4/NASP/DNAJC9/SMC2/RFC3/CHAF1A/RFC2/MCM3/SMC4/NCAPG/MCM5/MCM4/HAT1/NCAPD3/NAP1L1/ANP32B/MCM2/RPA1/XRCC5/RBBP4/SET/HMGA1/HNRNPA2B1/SRPK1/XRCC6 40 GO:0007346 regulation of mitotic cell cycle 49/436 457/18722 3.33752898443777e-19 8.17932996114715e-17 CLSPN/MKI67/CDK1/CDC6/DTL/CDCA5/BLM/PKMYT1/MAD2L1/BRCA1/ZWINT/CDT1/FBXO5/UBE2C/CHEK1/NUSAP1/CENPF/NDC80/MSH2/EZH2/CKS1B/RPA3/BRCA2/AURKB/ANLN/KIF20B/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RAD51C/RPA2/NUP62/CDK4/RBL1/EIF4EBP1/RNASEH2B/BUB3/TOPBP1/NAE1/TFDP1/ANAPC11/CCND1/CTDSPL/RDX/RAD21/BRD7/PHB2 49 GO:1901987 regulation of cell cycle phase transition 44/436 390/18722 3.54737188053205e-18 8.1140219480703e-16 CLSPN/CDK1/CDC6/DTL/CDCA5/BLM/WDR76/MAD2L1/CDC45/BRCA1/ZWINT/CDT1/FBXO5/UBE2C/CHEK1/CENPF/NDC80/MSH2/EZH2/ATAD5/AURKB/ANLN/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RAD51C/RPA2/CDK4/RBL1/DBF4/RNASEH2B/BUB3/TOPBP1/NAE1/TFDP1/ANAPC11/CCND1/CTDSPL/RDX/RAD21/BRD7/PHB2 44 GO:0044786 cell cycle DNA replication 17/436 41/18722 1.16158759030458e-17 2.49087938895938e-15 PCNA/FEN1/RAD51/BLM/CDC45/MCM6/GMNN/CDT1/LIG1/FBXO5/MCM3/BRCA2/MCM4/POLA1/TIPIN/DBF4/MCM2 17 GO:0000724 double-strand break repair via homologous recombination 27/436 138/18722 1.23435122426848e-17 2.49121120615597e-15 FEN1/GINS2/RAD51/RAD51AP1/BLM/CDC45/MCM6/BRCA1/MCM7/CHEK1/MCM3/RPA3/BRCA2/MCM5/MCM4/MMS22L/FUS/RMI2/RAD51C/RPA2/SMC6/PARP1/MCM2/NUCKS1/RPA1/RIF1/RAD21 27 GO:0000725 recombinational repair 27/436 140/18722 1.81852840267165e-17 3.46631719420358e-15 FEN1/GINS2/RAD51/RAD51AP1/BLM/CDC45/MCM6/BRCA1/MCM7/CHEK1/MCM3/RPA3/BRCA2/MCM5/MCM4/MMS22L/FUS/RMI2/RAD51C/RPA2/SMC6/PARP1/MCM2/NUCKS1/RPA1/RIF1/RAD21 27 GO:0033260 nuclear DNA replication 16/436 37/18722 4.6880348435139e-17 8.46560397268221e-15 PCNA/FEN1/RAD51/BLM/CDC45/MCM6/GMNN/CDT1/LIG1/MCM3/BRCA2/MCM4/POLA1/TIPIN/DBF4/MCM2 16 GO:1901990 regulation of mitotic cell cycle phase transition 37/436 299/18722 9.25495722214434e-17 1.58768791145886e-14 CLSPN/CDK1/CDC6/DTL/CDCA5/BLM/MAD2L1/BRCA1/ZWINT/CDT1/FBXO5/UBE2C/CHEK1/CENPF/NDC80/EZH2/AURKB/ANLN/GTSE1/TTK/PRKDC/RAD51C/RPA2/CDK4/RBL1/RNASEH2B/BUB3/TOPBP1/NAE1/TFDP1/ANAPC11/CCND1/CTDSPL/RDX/RAD21/BRD7/PHB2 37 GO:0006270 DNA replication initiation 15/436 34/18722 3.13581684317395e-16 5.12332742329991e-14 CDC6/MCM10/CCNE2/ORC6/CDC45/MCM6/CDT1/MCM7/MCM3/MCM5/MCM4/POLA1/MCM2/TOPBP1/CCNE1 15 GO:0006275 regulation of DNA replication 23/436 107/18722 3.70212536770743e-16 5.59853597927462e-14 PCNA/CDK1/CDC6/BLM/ESCO2/DSCC1/GMNN/CDT1/FBXO5/RFC4/CCNA2/RFC3/RFC2/ATAD5/BRCA2/SMC3/TIPIN/ID3/CACYBP/DBF4/JUN/NUCKS1/HRAS 23 GO:0000723 telomere maintenance 25/436 131/18722 3.75302615923394e-16 5.59853597927462e-14 PCNA/FEN1/RAD51/BLM/CCNE2/RPA3/BRCA2/AURKB/PRKDC/RAD51C/RPA2/RFC1/SMC6/PARP1/RPA1/HSP90AA1/XRCC5/CCNE1/HNRNPD/HNRNPA2B1/TPRKB/RIF1/CCT5/PTGES3/XRCC6 25 GO:1901988 negative regulation of cell cycle phase transition 33/436 249/18722 5.8783138446042e-16 8.40353950034876e-14 CLSPN/CDK1/CDC6/DTL/BLM/WDR76/MAD2L1/CDC45/BRCA1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/MSH2/EZH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/RBL1/RNASEH2B/BUB3/TOPBP1/NAE1/CCND1/CTDSPL/RAD21/BRD7 33 GO:0044839 cell cycle G2/M phase transition 26/436 148/18722 7.9068743782917e-16 1.08513943967675e-13 CLSPN/CDK1/CDC6/DTL/BLM/PKMYT1/BRCA1/FBXO5/CHEK1/CENPF/CCNA2/ATAD5/MELK/FOXM1/MASTL/AURKB/CALM2/RAD51C/CCNB2/CDK4/RNASEH2B/TOPBP1/NAE1/CCND1/RAD21/KHDRBS1 26 GO:0006271 DNA strand elongation involved in DNA replication 11/436 15/18722 1.21090255116515e-15 1.59792563578755e-13 PCNA/LIG1/MCM7/RFC4/RFC3/MCM3/POLD3/MCM4/POLA1/POLD2/POLE3 11 GO:0000075 cell cycle checkpoint signaling 27/436 169/18722 2.5679864932018e-15 3.26324505858347e-13 CLSPN/CDK1/CDC6/DTL/BLM/WDR76/MAD2L1/CDC45/BRCA1/ZWINT/CDT1/CHEK1/CENPF/NDC80/MSH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/RNASEH2B/BUB3/TOPBP1/NAE1/CCND1 27 GO:0007093 mitotic cell cycle checkpoint signaling 24/436 129/18722 2.70391113952186e-15 3.31325682846411e-13 CLSPN/CDK1/CDC6/DTL/BLM/MAD2L1/BRCA1/ZWINT/CDT1/CHEK1/CENPF/NDC80/MSH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/BUB3/TOPBP1/NAE1/CCND1 24 GO:0000086 G2/M transition of mitotic cell cycle 24/436 137/18722 1.11272650146964e-14 1.269877254481e-12 CLSPN/CDK1/CDC6/DTL/BLM/PKMYT1/BRCA1/FBXO5/CHEK1/CENPF/CCNA2/MELK/FOXM1/MASTL/AURKB/CALM2/RAD51C/CDK4/RNASEH2B/TOPBP1/NAE1/CCND1/RAD21/KHDRBS1 24 GO:1901991 negative regulation of mitotic cell cycle phase transition 27/436 179/18722 1.11423879636335e-14 1.269877254481e-12 CLSPN/CDK1/CDC6/DTL/BLM/MAD2L1/BRCA1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/EZH2/AURKB/GTSE1/TTK/PRKDC/RPA2/RBL1/BUB3/TOPBP1/NAE1/CCND1/CTDSPL/RAD21/BRD7 27 GO:0022616 DNA strand elongation 12/436 22/18722 1.14736796528449e-14 1.269877254481e-12 PCNA/LIG1/MCM7/RFC4/RFC3/MCM3/POLD3/MCM4/POLA1/POLD2/NUCKS1/POLE3 12 GO:0032392 DNA geometric change 20/436 90/18722 1.62716147170388e-14 1.7446221904425e-12 RAD51/BLM/DSCC1/MCM6/HMGB2/TOP2A/MCM7/HMGB1/RFC4/RFC3/RFC2/MCM3/MCM5/MCM4/MCM2/RPA1/XRCC5/HMGA1/HNRNPA2B1/XRCC6 20 GO:0045930 negative regulation of mitotic cell cycle 30/436 235/18722 3.56945650400867e-14 3.71115311068296e-12 CLSPN/CDK1/CDC6/DTL/BLM/MAD2L1/BRCA1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/MSH2/EZH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/RBL1/BUB3/TOPBP1/NAE1/CCND1/CTDSPL/RAD21/BRD7 30 GO:0032200 telomere organization 25/436 159/18722 4.1234701234739e-14 4.16106646871734e-12 PCNA/FEN1/RAD51/BLM/CCNE2/RPA3/BRCA2/AURKB/PRKDC/RAD51C/RPA2/RFC1/SMC6/PARP1/RPA1/HSP90AA1/XRCC5/CCNE1/HNRNPD/HNRNPA2B1/TPRKB/RIF1/CCT5/PTGES3/XRCC6 25 GO:0010948 negative regulation of cell cycle process 33/436 294/18722 7.71206660193475e-14 7.56002871749661e-12 CLSPN/CDK1/CDC6/DTL/BLM/WDR76/MAD2L1/CDC45/BRCA1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/MSH2/EZH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/RBL1/RNASEH2B/BUB3/TOPBP1/NAE1/CCND1/CTDSPL/RAD21/BRD7 33 GO:0090068 positive regulation of cell cycle process 29/436 236/18722 2.59534608417329e-13 2.47350900411071e-11 FEN1/CDK1/CDC6/RAD51AP1/DTL/CDCA5/MAD2L1/CDT1/FBXO5/UBE2C/NUSAP1/NDC80/EZH2/ATAD5/KIF23/RANBP1/AURKB/KIF20B/RAD51C/NUP62/CENPJ/CDK4/DBF4/TFDP1/ANAPC11/CCND1/RDX/RAD21/PHB2 29 GO:0045787 positive regulation of cell cycle 33/436 313/18722 4.56818919062007e-13 4.23606949000472e-11 FEN1/CDK1/CDC6/RAD51AP1/DTL/CDCA5/MAD2L1/CDT1/FBXO5/UBE2C/CHEK1/NUSAP1/NDC80/EZH2/ATAD5/KIF23/CKS1B/BRCA2/RANBP1/AURKB/KIF20B/RAD51C/NUP62/CENPJ/CDK4/DBF4/EIF4EBP1/TFDP1/ANAPC11/CCND1/RDX/RAD21/PHB2 33 GO:0071897 DNA biosynthetic process 25/436 180/18722 7.4621602607122e-13 6.73754522486936e-11 TYMS/PCNA/DTL/DSCC1/TK1/LIG1/RFC4/CENPF/RFC3/RFC2/POLD3/AURKB/POLA1/POLE2/RFC1/POLD2/RPA1/HSP90AA1/XRCC5/TFDP1/HNRNPD/POLE3/HNRNPA2B1/CCT5/PTGES3 25 GO:0051052 regulation of DNA metabolic process 35/436 359/18722 8.74582152001913e-13 7.69408041927837e-11 PCNA/RAD51/RAD51AP1/BLM/DSCC1/BRCA1/CDT1/HMGB1/CHEK1/RFC4/MSH2/RFC3/RFC2/DEK/USP1/FOXM1/AURKB/FUS/RMI2/MSH6/PRKDC/RPA2/PARP1/NUCKS1/HSP90AA1/XRCC5/TFDP1/HNRNPD/MGMT/HNRNPA2B1/RPS3/BAX/RIF1/CCT5/PTGES3 35 GO:0007051 spindle organization 25/436 184/18722 1.23482615587087e-12 1.05917213519824e-10 SPC25/MYBL2/PRC1/NUF2/FBXO5/STMN1/NDC80/TUBB/KIF23/TPX2/CENPH/AURKB/HAUS1/SMC3/TTK/ASPM/SAC3D1/HAUS8/NUP62/KPNB1/CENPJ/CCNB2/RAN/RPS3/SMC1A 25 GO:0140694 non-membrane-bounded organelle assembly 35/436 367/18722 1.65784652073449e-12 1.38733449088781e-10 MYBL2/PRC1/BRCA1/CENPW/FBXO5/CENPN/CENPF/TUBB/CENPK/KIF23/TPX2/CENPH/AURKB/ANLN/HAUS1/SMC3/ASPM/PRKDC/SAC3D1/LSM4/HAUS8/NUP62/KPNB1/CENPJ/CCNB2/CSRP2/XRCC5/CEP152/LSM3/SQLE/RPS3/RPL3/SMC1A/C1QBP/RPS5 35 GO:1902969 mitotic DNA replication 9/436 14/18722 3.35250313160251e-12 2.73867577250672e-10 RAD51/CDC45/MCM6/LIG1/MCM3/BRCA2/MCM4/POLA1/MCM2 9 GO:0045786 negative regulation of cell cycle 35/436 385/18722 6.54378141121356e-12 5.22132884229622e-10 CLSPN/CDK1/CDC6/DTL/BLM/WDR76/MAD2L1/CDC45/GMNN/BRCA1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/MSH2/EZH2/AURKB/FANCD2/GTSE1/TIPIN/TTK/PRKDC/RPA2/RBL1/CDKN2A/RNASEH2B/BUB3/TOPBP1/NAE1/CCND1/CTDSPL/RAD21/BRD7 35 GO:0032508 DNA duplex unwinding 17/436 84/18722 7.81283877782926e-12 6.05329841536051e-10 RAD51/BLM/DSCC1/MCM6/TOP2A/MCM7/RFC4/RFC3/RFC2/MCM3/MCM5/MCM4/MCM2/RPA1/XRCC5/HMGA1/XRCC6 17 GO:0031570 DNA integrity checkpoint signaling 20/436 123/18722 7.93933047773893e-12 6.05329841536051e-10 CLSPN/CDK1/CDC6/DTL/BLM/WDR76/CDC45/BRCA1/CDT1/CHEK1/MSH2/FANCD2/GTSE1/TIPIN/PRKDC/RPA2/RNASEH2B/TOPBP1/NAE1/CCND1 20 GO:0051054 positive regulation of DNA metabolic process 25/436 201/18722 9.08807883753027e-12 6.77852141121007e-10 PCNA/RAD51/RAD51AP1/DSCC1/BRCA1/HMGB1/RFC4/MSH2/RFC3/RFC2/FOXM1/AURKB/FUS/PRKDC/PARP1/HSP90AA1/XRCC5/HNRNPD/MGMT/HNRNPA2B1/RPS3/BAX/RIF1/CCT5/PTGES3 25 GO:1902749 regulation of cell cycle G2/M phase transition 18/436 102/18722 2.15502323810493e-11 1.51994573019386e-09 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/FBXO5/CHEK1/CENPF/ATAD5/AURKB/RAD51C/CDK4/RNASEH2B/TOPBP1/NAE1/CCND1/RAD21 18 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 31/436 320/18722 2.17071818069074e-11 1.51994573019386e-09 SNRPD1/PSIP1/LSM4/SNRPG/SRSF7/LSM2/HNRNPF/HNRNPR/SRSF2/HNRNPA3/SNRPE/SRSF10/SNRNP25/SNRPB/LSM3/LSM8/MAGOHB/HSPA8/RBM17/SNRPF/HNRNPA2B1/LSM5/PNN/SRPK1/SNRPA1/RBMX/SRRM1/C1QBP/SRSF3/KHDRBS1/SNRPD3 31 GO:0000398 mRNA splicing, via spliceosome 31/436 320/18722 2.17071818069074e-11 1.51994573019386e-09 SNRPD1/PSIP1/LSM4/SNRPG/SRSF7/LSM2/HNRNPF/HNRNPR/SRSF2/HNRNPA3/SNRPE/SRSF10/SNRNP25/SNRPB/LSM3/LSM8/MAGOHB/HSPA8/RBM17/SNRPF/HNRNPA2B1/LSM5/PNN/SRPK1/SNRPA1/RBMX/SRRM1/C1QBP/SRSF3/KHDRBS1/SNRPD3 31 GO:0000375 RNA splicing, via transesterification reactions 31/436 324/18722 2.98562589331261e-11 2.04873648799111e-09 SNRPD1/PSIP1/LSM4/SNRPG/SRSF7/LSM2/HNRNPF/HNRNPR/SRSF2/HNRNPA3/SNRPE/SRSF10/SNRNP25/SNRPB/LSM3/LSM8/MAGOHB/HSPA8/RBM17/SNRPF/HNRNPA2B1/LSM5/PNN/SRPK1/SNRPA1/RBMX/SRRM1/C1QBP/SRSF3/KHDRBS1/SNRPD3 31 GO:0010212 response to ionizing radiation 21/436 148/18722 3.47861749917089e-11 2.34022287052065e-09 RAD51/RAD51AP1/BLM/RRM1/BRCA1/MSH2/BRCA2/FANCD2/PRKDC/PARP1/NUCKS1/TOPBP1/XRCC5/MGMT/TMEM109/IKBIP/HRAS/CCND1/BAX/XRCC6/GPX1 21 GO:0051383 kinetochore organization 10/436 23/18722 3.69574583465958e-11 2.3974724230293e-09 CDT1/NUF2/CENPW/CENPN/CENPF/NDC80/CENPK/SMC2/CENPH/SMC4 10 GO:0000727 double-strand break repair via break-induced replication 8/436 12/18722 3.70346949637287e-11 2.3974724230293e-09 GINS2/CDC45/MCM6/MCM7/MCM3/MCM5/MCM4/MCM2 8 GO:0008380 RNA splicing 36/436 434/18722 4.50890350735162e-11 2.86482369143026e-09 SNRPD1/FUS/PSIP1/LSM4/SNRPG/SRSF7/LSM2/HNRNPF/HNRNPR/SRSF2/HNRNPA3/SNRPE/SRSF10/TSEN34/SNRNP25/SNRPB/ZNF326/LSM3/LSM8/MAGOHB/HSPA8/CTNNBL1/RBM17/SNRPF/HNRNPA2B1/LSM5/PNN/SRPK1/YBX1/SNRPA1/RBMX/SRRM1/C1QBP/SRSF3/KHDRBS1/SNRPD3 36 GO:0006323 DNA packaging 24/436 199/18722 4.60334550092188e-11 2.87165062066599e-09 HELLS/CDK1/ASF1B/CDCA5/HMGB2/TOP2A/CENPW/NCAPH/HMGB1/NUSAP1/NASP/DNAJC9/SMC2/CHAF1A/SMC4/NCAPG/HAT1/NCAPD3/NAP1L1/ANP32B/MCM2/RBBP4/SET/SRPK1 24 GO:0010389 regulation of G2/M transition of mitotic cell cycle 17/436 94/18722 5.2013548767105e-11 3.18675867535602e-09 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/FBXO5/CHEK1/CENPF/AURKB/RAD51C/CDK4/RNASEH2B/TOPBP1/NAE1/CCND1/RAD21 17 GO:0033044 regulation of chromosome organization 23/436 187/18722 7.86538476431247e-11 4.73440967129054e-09 FEN1/CDC6/CDCA5/MAD2L1/ZWINT/CDT1/TOP2A/FBXO5/UBE2C/CENPF/NDC80/AURKB/RMI2/TTK/PARP1/MCM2/BUB3/XRCC5/HNRNPD/HNRNPA2B1/ANAPC11/CCT5/RAD21 23 GO:0071824 protein-DNA complex subunit organization 26/436 241/18722 8.8161873746955e-11 5.21523084182418e-09 HELLS/RAD51/ASF1B/CDC45/GMNN/HMGB2/CDT1/CENPW/HMGB1/CENPN/CENPF/NASP/DNAJC9/CENPK/CHAF1A/CENPH/HAT1/RAD51C/SUPT16H/NAP1L1/ANP32B/MCM2/RBBP4/SET/POLE3/HMGA1 26 GO:0044774 mitotic DNA integrity checkpoint signaling 16/436 85/18722 1.029043009433e-10 5.984146720957e-09 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/CHEK1/MSH2/FANCD2/GTSE1/TIPIN/PRKDC/RPA2/TOPBP1/NAE1/CCND1 16 GO:0051983 regulation of chromosome segregation 16/436 91/18722 2.99759931650181e-10 1.71412720915295e-08 MKI67/CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/RMI2/TTK/SMC6/BUB3/ANAPC11/RAD21 16 GO:0065004 protein-DNA complex assembly 23/436 201/18722 3.39651184509333e-10 1.91039871155987e-08 HELLS/RAD51/ASF1B/CDC45/GMNN/HMGB2/CDT1/CENPW/HMGB1/CENPN/CENPF/NASP/DNAJC9/CENPK/CHAF1A/CENPH/HAT1/RAD51C/NAP1L1/ANP32B/MCM2/RBBP4/SET 23 GO:0034502 protein localization to chromosome 16/436 92/18722 3.55217351601811e-10 1.96572698926744e-08 CDK1/CDCA5/ESCO2/CDT1/NDC80/MSH2/EZH2/BRCA2/AURKB/TTK/RPA2/BUB3/RPA1/XRCC5/CCT5/RAD21 16 GO:0090329 regulation of DNA-dependent DNA replication 12/436 46/18722 4.16053100540015e-10 2.26583839357586e-08 PCNA/BLM/DSCC1/GMNN/CDT1/FBXO5/RFC4/RFC3/RFC2/BRCA2/TIPIN/DBF4 12 GO:0006268 DNA unwinding involved in DNA replication 8/436 15/18722 4.52711141734561e-10 2.42695613639262e-08 RAD51/BLM/MCM6/MCM7/MCM4/MCM2/RPA1/HMGA1 8 GO:0007088 regulation of mitotic nuclear division 17/436 110/18722 6.77698591804885e-10 3.57720595151163e-08 MKI67/PKMYT1/MAD2L1/ZWINT/CDT1/FBXO5/CHEK1/NUSAP1/CENPF/NDC80/AURKB/KIF20B/TTK/NUP62/BUB3/ANAPC11/RAD21 17 GO:0009314 response to radiation 35/436 456/18722 6.93705232140852e-10 3.60621613859888e-08 PCNA/FEN1/RAD51/RAD51AP1/DTL/BLM/RRM1/PBK/BRCA1/CHEK1/MSH2/USP1/POLD3/BRCA2/AURKB/FANCD2/TIPIN/MSH6/PRKDC/PARP1/JUN/NUCKS1/TOPBP1/COPS3/XRCC5/MGMT/HMGN1/TMEM109/IKBIP/HRAS/CCND1/SMC1A/BAX/XRCC6/GPX1 35 GO:0030071 regulation of mitotic metaphase/anaphase transition 13/436 60/18722 9.48173540041126e-10 4.85549763564344e-08 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0033045 regulation of sister chromatid segregation 14/436 72/18722 9.78632429107328e-10 4.93777627098124e-08 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/RMI2/TTK/BUB3/ANAPC11/RAD21 14 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 13/436 62/18722 1.4615107242651e-09 7.26730912312108e-08 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:1902850 microtubule cytoskeleton organization involved in mitosis 19/436 147/18722 1.52537392207081e-09 7.47651132374992e-08 MAD2L1/SPC25/MYBL2/PRC1/NUF2/STMN1/NUSAP1/NDC80/KIF23/TPX2/CENPH/AURKB/SMC3/TTK/NUP62/KPNB1/RAN/SMC1A/DYNLT1 19 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 13/436 63/18722 1.80297037499709e-09 8.71266388255636e-08 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0051321 meiotic cell cycle 25/436 261/18722 2.49502560302064e-09 1.18894900610609e-07 RAD51/RAD51AP1/PKMYT1/CCNE2/MND1/NUF2/TOP2A/FBXO5/SMC2/PSMC3IP/BRCA2/SMC4/FANCD2/SMC3/NCAPD3/TTK/ASPM/MSH6/RAD51C/CCNB2/BUB3/RPA1/CCNE1/SMC1A/RAD21 25 GO:0010965 regulation of mitotic sister chromatid separation 13/436 65/18722 2.71108170998255e-09 1.25698937120948e-07 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0044784 metaphase/anaphase transition of cell cycle 13/436 65/18722 2.71108170998255e-09 1.25698937120948e-07 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0051783 regulation of nuclear division 18/436 139/18722 4.00351205611761e-09 1.81274161508646e-07 MKI67/RAD51AP1/PKMYT1/MAD2L1/ZWINT/CDT1/FBXO5/CHEK1/NUSAP1/CENPF/NDC80/AURKB/KIF20B/TTK/NUP62/BUB3/ANAPC11/RAD21 18 GO:0051306 mitotic sister chromatid separation 13/436 67/18722 4.01539967200732e-09 1.81274161508646e-07 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0006298 mismatch repair 10/436 35/18722 4.61692113641245e-09 2.05722810636768e-07 PCNA/LIG1/HMGB1/MSH2/RNASEH2A/POLD3/RPA3/MSH6/RPA2/RPA1 10 GO:0044773 mitotic DNA damage checkpoint signaling 14/436 81/18722 4.93369052996447e-09 2.17019130875745e-07 CLSPN/CDK1/DTL/BLM/BRCA1/CHEK1/MSH2/FANCD2/GTSE1/TIPIN/PRKDC/RPA2/TOPBP1/CCND1 14 GO:0006282 regulation of DNA repair 17/436 130/18722 9.33835888668097e-09 4.0556847266079e-07 PCNA/RAD51/RAD51AP1/BRCA1/HMGB1/CHEK1/DEK/USP1/FOXM1/FUS/RMI2/PRKDC/RPA2/PARP1/MGMT/RPS3/RIF1 17 GO:0045839 negative regulation of mitotic nuclear division 11/436 48/18722 1.00248910370808e-08 4.27469952257542e-07 MAD2L1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 11 GO:1905818 regulation of chromosome separation 13/436 72/18722 1.00966063826185e-08 4.27469952257542e-07 CDC6/MAD2L1/ZWINT/CDT1/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 13 GO:0000077 DNA damage checkpoint signaling 16/436 115/18722 1.03410102120012e-08 4.27469952257542e-07 CLSPN/CDK1/DTL/BLM/WDR76/BRCA1/CHEK1/MSH2/FANCD2/GTSE1/TIPIN/PRKDC/RPA2/RNASEH2B/TOPBP1/CCND1 16 GO:1901989 positive regulation of cell cycle phase transition 16/436 115/18722 1.03410102120012e-08 4.27469952257542e-07 CDK1/CDC6/DTL/CDCA5/CDT1/FBXO5/UBE2C/EZH2/ATAD5/RAD51C/CDK4/TFDP1/ANAPC11/CCND1/RDX/PHB2 16 GO:0051225 spindle assembly 16/436 117/18722 1.33167262985637e-08 5.43924856313954e-07 MYBL2/PRC1/FBXO5/TUBB/KIF23/TPX2/AURKB/HAUS1/SMC3/ASPM/SAC3D1/HAUS8/KPNB1/CCNB2/RPS3/SMC1A 16 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 10/436 40/18722 1.9208965178491e-08 7.68653207451727e-07 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:0007052 mitotic spindle organization 16/436 120/18722 1.92667373479593e-08 7.68653207451727e-07 SPC25/MYBL2/PRC1/NUF2/STMN1/NDC80/KIF23/TPX2/CENPH/AURKB/SMC3/TTK/NUP62/KPNB1/RAN/SMC1A 16 GO:0042770 signal transduction in response to DNA damage 19/436 172/18722 2.12347157917611e-08 8.37428849213016e-07 CLSPN/CDK1/DTL/BLM/WDR76/BRCA1/CHEK1/MSH2/BRCA2/FOXM1/FANCD2/GTSE1/TIPIN/PRKDC/RPA2/RNASEH2B/TOPBP1/EEF1E1/CCND1 19 GO:0045931 positive regulation of mitotic cell cycle 16/436 121/18722 2.17351268915294e-08 8.47422958691335e-07 CDK1/CDC6/DTL/CDCA5/CDT1/FBXO5/UBE2C/BRCA2/RAD51C/CDK4/EIF4EBP1/TFDP1/ANAPC11/CCND1/RDX/PHB2 16 GO:1901992 positive regulation of mitotic cell cycle phase transition 14/436 93/18722 3.11227587101926e-08 1.19979983297383e-06 CDK1/CDC6/DTL/CDCA5/CDT1/FBXO5/UBE2C/RAD51C/CDK4/TFDP1/ANAPC11/CCND1/RDX/PHB2 14 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 10/436 42/18722 3.19842424401931e-08 1.21931039791447e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:0006325 chromatin organization 30/436 409/18722 3.32734871066893e-08 1.25452015673682e-06 HELLS/MKI67/ATAD2/ASF1B/HMGB2/CENPW/HMGB1/NASP/DNAJC9/EZH2/CHAF1A/DEK/HAT1/HIRIP3/HMGN2/SUPT16H/NAP1L1/RBL1/ANP32B/MCM2/BAZ1B/NUCKS1/RBBP4/SET/HMGN1/POLE3/HMGA1/SSRP1/SRPK1/CBX3 30 GO:0006284 base-excision repair 10/436 43/18722 4.08176405650022e-08 1.47416131345813e-06 PCNA/FEN1/LIG1/UNG/HMGB1/RPA3/RPA2/PARP2/RPA1/RPS3 10 GO:0033046 negative regulation of sister chromatid segregation 10/436 43/18722 4.08176405650022e-08 1.47416131345813e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:0033048 negative regulation of mitotic sister chromatid segregation 10/436 43/18722 4.08176405650022e-08 1.47416131345813e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:2000816 negative regulation of mitotic sister chromatid separation 10/436 43/18722 4.08176405650022e-08 1.47416131345813e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:0010165 response to X-ray 9/436 33/18722 4.35820442806089e-08 1.55760410340385e-06 RAD51/BLM/MSH2/BRCA2/NUCKS1/XRCC5/IKBIP/CCND1/XRCC6 9 GO:2001020 regulation of response to DNA damage stimulus 21/436 219/18722 4.69891612231803e-08 1.64972125052282e-06 PCNA/RAD51/RAD51AP1/WDR76/BRCA1/FBXO5/HMGB1/CHEK1/DEK/USP1/FOXM1/FUS/RMI2/PRKDC/RPA2/PARP1/RNASEH2B/EEF1E1/MGMT/RPS3/RIF1 21 GO:0051304 chromosome separation 14/436 96/18722 4.7121154926038e-08 1.64972125052282e-06 CDC6/MAD2L1/ZWINT/CDT1/TOP2A/FBXO5/UBE2C/CENPF/NDC80/AURKB/TTK/BUB3/ANAPC11/RAD21 14 GO:0010332 response to gamma radiation 11/436 56/18722 5.58709873332762e-08 1.89329531068404e-06 RAD51/BRCA2/FANCD2/PRKDC/PARP1/XRCC5/TMEM109/HRAS/BAX/XRCC6/GPX1 11 GO:0051784 negative regulation of nuclear division 11/436 56/18722 5.58709873332762e-08 1.89329531068404e-06 MAD2L1/ZWINT/CDT1/FBXO5/CHEK1/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 11 GO:0000076 DNA replication checkpoint signaling 7/436 17/18722 5.62856664790942e-08 1.89329531068404e-06 CLSPN/CDC6/CDC45/CDT1/TIPIN/TOPBP1/NAE1 7 GO:0007076 mitotic chromosome condensation 7/436 17/18722 5.62856664790942e-08 1.89329531068404e-06 CDCA5/NCAPH/NUSAP1/SMC2/SMC4/NCAPG/NCAPD3 7 GO:1903046 meiotic cell cycle process 20/436 202/18722 5.77897659353151e-08 1.92501637790356e-06 RAD51/RAD51AP1/CCNE2/MND1/NUF2/TOP2A/FBXO5/SMC2/PSMC3IP/BRCA2/SMC4/FANCD2/NCAPD3/TTK/ASPM/MSH6/RAD51C/CCNB2/CCNE1/RAD21 20 GO:0051985 negative regulation of chromosome segregation 10/436 45/18722 6.51455538065366e-08 2.12870852485931e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:1905819 negative regulation of chromosome separation 10/436 45/18722 6.51455538065366e-08 2.12870852485931e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:0009411 response to UV 17/436 149/18722 7.32005951498498e-08 2.36935133923712e-06 PCNA/FEN1/DTL/PBK/CHEK1/MSH2/USP1/POLD3/BRCA2/AURKB/TIPIN/MSH6/PARP1/HMGN1/CCND1/BAX/GPX1 17 GO:0033047 regulation of mitotic sister chromatid segregation 10/436 46/18722 8.15270005941951e-08 2.61419756110919e-06 MAD2L1/ZWINT/CDT1/FBXO5/CENPF/NDC80/AURKB/TTK/BUB3/RAD21 10 GO:2001251 negative regulation of chromosome organization 13/436 86/18722 9.22104578638834e-08 2.92938963824985e-06 MAD2L1/ZWINT/CDT1/TOP2A/FBXO5/CENPF/NDC80/AURKB/TTK/PARP1/MCM2/BUB3/RAD21 13 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 11/436 60/18722 1.18259736457487e-07 3.72246931913429e-06 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/CHEK1/AURKB/TOPBP1/NAE1/RAD21 11 GO:0007062 sister chromatid cohesion 11/436 62/18722 1.68206882951093e-07 5.19925959824504e-06 FEN1/CDCA5/ESCO2/DSCC1/SMC3/RAD51C/MCMBP/KIF22/SMC1A/RAD21/PHB2 11 GO:1902750 negative regulation of cell cycle G2/M phase transition 11/436 62/18722 1.68206882951093e-07 5.19925959824504e-06 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/CHEK1/AURKB/TOPBP1/NAE1/RAD21 11 GO:0006333 chromatin assembly or disassembly 18/436 177/18722 1.78054614750727e-07 5.45451235008701e-06 HELLS/ASF1B/HMGB2/CENPW/HMGB1/NASP/DNAJC9/CHAF1A/HAT1/HIRIP3/SUPT16H/NAP1L1/ANP32B/MCM2/BAZ1B/RBBP4/SET/HMGA1 18 GO:0044843 cell cycle G1/S phase transition 21/436 241/18722 2.40492183167571e-07 7.30202372077819e-06 CDC6/CCNE2/NASP/CCNA2/EZH2/GTSE1/PRKDC/RPA2/CDK4/RBL1/DBF4/CDKN2A/EIF4EBP1/CCNE1/TFDP1/CCND1/CTDSPL/RDX/KHDRBS1/BRD7/PHB2 21 GO:0140013 meiotic nuclear division 18/436 185/18722 3.46261360805784e-07 1.04212520081109e-05 RAD51/RAD51AP1/CCNE2/MND1/NUF2/TOP2A/FBXO5/SMC2/PSMC3IP/BRCA2/SMC4/FANCD2/TTK/ASPM/RAD51C/CCNB2/CCNE1/RAD21 18 GO:0022613 ribonucleoprotein complex biogenesis 30/436 463/18722 4.91779999218614e-07 1.46721493679919e-05 SNRPD1/NOP56/PSIP1/PRKDC/EXOSC9/LSM4/PA2G4/EXOSC8/SNRPG/LSM2/RAN/RPS21/SNRPE/SRSF10/SNRPB/HSP90AA1/XRCC5/POP7/RPP30/SNRPF/RPS17/RPL35/RPL3/SRPK1/RPS7/RPL7A/C1QBP/PTGES3/RPS5/SNRPD3 30 GO:2000779 regulation of double-strand break repair 12/436 85/18722 6.19232776818607e-07 1.83154108384883e-05 RAD51/RAD51AP1/CHEK1/DEK/FOXM1/FUS/RMI2/PRKDC/RPA2/PARP1/MGMT/RIF1 12 GO:0009262 deoxyribonucleotide metabolic process 9/436 44/18722 6.38365753624965e-07 1.87199393221133e-05 TYMS/RRM2/RRM1/DUT/UNG/DTYMK/DCTPP1/NUDT15/DNPH1 9 GO:0000082 G1/S transition of mitotic cell cycle 19/436 214/18722 6.77701628104872e-07 1.97050363222696e-05 CDC6/CCNE2/NASP/EZH2/GTSE1/PRKDC/RPA2/CDK4/RBL1/DBF4/CDKN2A/EIF4EBP1/CCNE1/TFDP1/CCND1/CTDSPL/RDX/KHDRBS1/BRD7 19 GO:0045739 positive regulation of DNA repair 11/436 73/18722 9.35702868330416e-07 2.6978122195308e-05 PCNA/RAD51AP1/BRCA1/HMGB1/FOXM1/FUS/PRKDC/PARP1/MGMT/RPS3/RIF1 11 GO:0044818 mitotic G2/M transition checkpoint 9/436 46/18722 9.51976052954397e-07 2.72185819807211e-05 CLSPN/CDK1/CDC6/DTL/BLM/BRCA1/CHEK1/TOPBP1/NAE1 9 GO:0006266 DNA ligation 6/436 16/18722 1.01261052043616e-06 2.87129478976568e-05 RAD51/TOP2A/LIG1/HMGB1/MGMT/XRCC6 6 GO:2000278 regulation of DNA biosynthetic process 13/436 106/18722 1.10579288642415e-06 3.10981589616497e-05 PCNA/DSCC1/RFC4/RFC3/RFC2/AURKB/HSP90AA1/XRCC5/TFDP1/HNRNPD/HNRNPA2B1/CCT5/PTGES3 13 GO:0030261 chromosome condensation 9/436 48/18722 1.39063827905062e-06 3.87908937839241e-05 CDK1/CDCA5/TOP2A/NCAPH/NUSAP1/SMC2/SMC4/NCAPG/NCAPD3 9 GO:0000387 spliceosomal snRNP assembly 9/436 50/18722 1.99361219192375e-06 5.5161963149116e-05 SNRPD1/LSM4/SNRPG/LSM2/SNRPE/SRSF10/SNRPB/SNRPF/SNRPD3 9 GO:0007094 mitotic spindle assembly checkpoint signaling 8/436 38/18722 2.14920166070158e-06 5.80622905343866e-05 MAD2L1/ZWINT/CDT1/CENPF/NDC80/AURKB/TTK/BUB3 8 GO:0071173 spindle assembly checkpoint signaling 8/436 38/18722 2.14920166070158e-06 5.80622905343866e-05 MAD2L1/ZWINT/CDT1/CENPF/NDC80/AURKB/TTK/BUB3 8 GO:0071174 mitotic spindle checkpoint signaling 8/436 38/18722 2.14920166070158e-06 5.80622905343866e-05 MAD2L1/ZWINT/CDT1/CENPF/NDC80/AURKB/TTK/BUB3 8 GO:0007569 cell aging 14/436 132/18722 2.51807419358137e-06 6.7496191860763e-05 CDK1/FBXO5/CHEK1/BRCA2/FOXM1/PRKDC/NUP62/SMC6/RBL1/CDKN2A/EEF1E1/HMGA1/HRAS/YBX1 14 GO:0031577 spindle checkpoint signaling 8/436 39/18722 2.6492384065763e-06 7.04615269221961e-05 MAD2L1/ZWINT/CDT1/CENPF/NDC80/AURKB/TTK/BUB3 8 GO:2000573 positive regulation of DNA biosynthetic process 10/436 66/18722 2.78479099519092e-06 7.34970608038466e-05 PCNA/DSCC1/RFC4/RFC3/RFC2/AURKB/HSP90AA1/XRCC5/CCT5/PTGES3 10 GO:0034501 protein localization to kinetochore 6/436 19/18722 3.23292905872935e-06 8.37034313709854e-05 CDK1/CDT1/NDC80/AURKB/TTK/BUB3 6 GO:1903083 protein localization to condensed chromosome 6/436 19/18722 3.23292905872935e-06 8.37034313709854e-05 CDK1/CDT1/NDC80/AURKB/TTK/BUB3 6 GO:0045740 positive regulation of DNA replication 8/436 40/18722 3.24469728135851e-06 8.37034313709854e-05 PCNA/CDK1/CDT1/ATAD5/CACYBP/DBF4/JUN/HRAS 8 GO:0061982 meiosis I cell cycle process 14/436 135/18722 3.29102427124621e-06 8.42649572734756e-05 RAD51/RAD51AP1/CCNE2/MND1/TOP2A/FBXO5/PSMC3IP/BRCA2/FANCD2/MSH6/RAD51C/CCNB2/CCNE1/RAD21 14 GO:0070192 chromosome organization involved in meiotic cell cycle 10/436 69/18722 4.21743517583391e-06 0.000107185333987305 RAD51/CCNE2/SMC2/PSMC3IP/SMC4/FANCD2/NCAPD3/RAD51C/CCNE1/RAD21 10 GO:0034508 centromere complex assembly 7/436 30/18722 4.53312137721566e-06 0.000113526565293627 HELLS/CENPW/CENPN/CENPF/NASP/CENPK/CENPH 7 GO:1902751 positive regulation of cell cycle G2/M phase transition 7/436 30/18722 4.53312137721566e-06 0.000113526565293627 CDK1/DTL/FBXO5/ATAD5/RAD51C/CDK4/CCND1 7 GO:2001022 positive regulation of response to DNA damage stimulus 12/436 105/18722 6.0384121610191e-06 0.000150128928438091 PCNA/RAD51AP1/BRCA1/HMGB1/FOXM1/FUS/PRKDC/PARP1/EEF1E1/MGMT/RPS3/RIF1 12 GO:0010639 negative regulation of organelle organization 23/436 347/18722 7.44961563415212e-06 0.000183882239142273 MAD2L1/BRCA1/ZWINT/CDT1/TOP2A/FBXO5/STMN1/CHEK1/CENPF/NDC80/TPX2/AURKB/TTK/PARP1/MCM2/BUB3/CKAP2/SLC25A5/PPIF/TACSTD2/RDX/RAD21/GPX1 23 GO:0071478 cellular response to radiation 16/436 186/18722 7.71194021873432e-06 0.000188997620646267 PCNA/RAD51/RAD51AP1/BLM/PBK/CHEK1/POLD3/AURKB/PARP1/NUCKS1/XRCC5/MGMT/TMEM109/HRAS/BAX/XRCC6 16 GO:0034728 nucleosome organization 15/436 167/18722 8.78790869889641e-06 0.000213839111673146 ASF1B/HMGB2/CENPW/NASP/DNAJC9/CHAF1A/HAT1/SUPT16H/NAP1L1/ANP32B/MCM2/RBBP4/SET/POLE3/HMGA1 15 GO:0035825 homologous recombination 9/436 60/18722 9.57531282582971e-06 0.000231358438770576 RAD51/RAD51AP1/MND1/TOP2A/PSMC3IP/FANCD2/RAD51C/NUCKS1/RAD21 9 GO:0007127 meiosis I 13/436 129/18722 1.00824971987317e-05 0.000241909425796142 RAD51/RAD51AP1/CCNE2/MND1/TOP2A/FBXO5/PSMC3IP/BRCA2/FANCD2/RAD51C/CCNB2/CCNE1/RAD21 13 GO:0045132 meiotic chromosome segregation 11/436 93/18722 1.05613456860289e-05 0.000251638729505315 CCNE2/NUF2/TOP2A/SMC2/PSMC3IP/SMC4/FANCD2/TTK/RAD51C/CCNE1/RAD21 11 GO:0007095 mitotic G2 DNA damage checkpoint signaling 7/436 34/18722 1.10527559325407e-05 0.000261531073134809 CLSPN/CDK1/DTL/BLM/BRCA1/CHEK1/TOPBP1 7 GO:0034655 nucleobase-containing compound catabolic process 25/436 407/18722 1.12592264132844e-05 0.000264591820712183 FEN1/DUT/UNG/RNASEH2A/CARHSP1/NUDT8/FUS/HINT1/EXOSC9/LSM4/DCTPP1/EXOSC8/SERBP1/LSM2/NUDT1/HNRNPR/RNASEH2B/NUDT15/DNPH1/HNRNPD/MAGOHB/RNASEH2C/LSM5/BAX/YBX1 25 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 11/436 94/18722 1.17144385224156e-05 0.00027341658891434 CDC6/BLM/PKMYT1/CCNE2/CCNA2/CKS1B/HERC5/CCNB2/CDKN2A/CCNE1/CCND1 11 GO:0031497 chromatin assembly 14/436 151/18722 1.215742259346e-05 0.000281838627825413 HELLS/ASF1B/HMGB2/CENPW/HMGB1/NASP/DNAJC9/CHAF1A/HAT1/NAP1L1/ANP32B/MCM2/RBBP4/SET 14 GO:0010569 regulation of double-strand break repair via homologous recombination 8/436 48/18722 1.35266038953582e-05 0.000311475019899153 RAD51/RAD51AP1/CHEK1/FUS/RMI2/RPA2/PARP1/RIF1 8 GO:0097193 intrinsic apoptotic signaling pathway 20/436 288/18722 1.49356599851498e-05 0.000341628329393659 HELLS/BRCA1/MSH2/MELK/BRCA2/HINT1/MSH6/PRKDC/PARP1/PPIA/PPIF/ENO1/TMEM109/HRAS/RPS3/BAX/RPS7/PERP/ERP29/GPX1 20 GO:0007568 aging 22/436 339/18722 1.63176797053706e-05 0.000366813892495233 TYMS/CDK1/FBXO5/CHEK1/MSH2/BRCA2/FOXM1/AURKB/MSH6/PRKDC/NUP62/SMC6/CACYBP/RBL1/NUDT1/CDKN2A/JUN/EEF1E1/CTSV/HMGA1/HRAS/YBX1 22 GO:0000722 telomere maintenance via recombination 5/436 15/18722 1.65772967601006e-05 0.000366813892495233 RAD51/BRCA2/RAD51C/SMC6/TPRKB 5 GO:0009263 deoxyribonucleotide biosynthetic process 5/436 15/18722 1.65772967601006e-05 0.000366813892495233 TYMS/RRM2/RRM1/DUT/DTYMK 5 GO:0033599 regulation of mammary gland epithelial cell proliferation 5/436 15/18722 1.65772967601006e-05 0.000366813892495233 BRCA2/CCND1/BAX/PHB2/GPX1 5 GO:2000104 negative regulation of DNA-dependent DNA replication 5/436 15/18722 1.65772967601006e-05 0.000366813892495233 BLM/GMNN/FBXO5/BRCA2/TIPIN 5 GO:0022618 ribonucleoprotein complex assembly 17/436 220/18722 1.66782183705206e-05 0.000366813892495233 SNRPD1/PSIP1/PRKDC/LSM4/SNRPG/LSM2/SNRPE/SRSF10/SNRPB/HSP90AA1/XRCC5/SNRPF/RPL3/SRPK1/PTGES3/RPS5/SNRPD3 17 GO:1904029 regulation of cyclin-dependent protein kinase activity 11/436 98/18722 1.74912643922318e-05 0.000382245402100302 CDC6/BLM/PKMYT1/CCNE2/CCNA2/CKS1B/HERC5/CCNB2/CDKN2A/CCNE1/CCND1 11 GO:0010833 telomere maintenance via telomere lengthening 10/436 81/18722 1.81703118242503e-05 0.000394571771322802 RAD51/AURKB/RFC1/PARP1/RPA1/HSP90AA1/XRCC5/HNRNPA2B1/CCT5/PTGES3 10 GO:0007080 mitotic metaphase plate congression 8/436 50/18722 1.84777926833429e-05 0.000398725199349368 CDCA5/CDT1/NUF2/NDC80/AURKB/NUP62/KPNB1/KIF22 8 GO:0051310 metaphase plate congression 9/436 65/18722 1.86838974473012e-05 0.000399404112543742 CDCA5/CDT1/NUF2/CENPF/NDC80/AURKB/NUP62/KPNB1/KIF22 9 GO:0071459 protein localization to chromosome, centromeric region 6/436 25/18722 1.8742075814498e-05 0.000399404112543742 CDK1/CDT1/NDC80/AURKB/TTK/BUB3 6 GO:0071826 ribonucleoprotein complex subunit organization 17/436 227/18722 2.49797790410814e-05 0.000529047048703398 SNRPD1/PSIP1/PRKDC/LSM4/SNRPG/LSM2/SNRPE/SRSF10/SNRPB/HSP90AA1/XRCC5/SNRPF/RPL3/SRPK1/PTGES3/RPS5/SNRPD3 17 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 6/436 27/18722 3.0113532151213e-05 0.000633862139943632 CDK1/DTL/FBXO5/RAD51C/CDK4/CCND1 6 GO:0006338 chromatin remodeling 18/436 255/18722 3.20020581708999e-05 0.000669506473075351 HELLS/ASF1B/HMGB2/CENPW/NASP/DNAJC9/CHAF1A/HAT1/SUPT16H/NAP1L1/ANP32B/MCM2/BAZ1B/RBBP4/SET/POLE3/HMGA1/CBX3 18 GO:0009200 deoxyribonucleoside triphosphate metabolic process 5/436 17/18722 3.28679507596028e-05 0.000683454176098164 TYMS/DUT/DTYMK/DCTPP1/NUDT15 5 GO:0009394 2'-deoxyribonucleotide metabolic process 7/436 40/18722 3.39560239756423e-05 0.000697623462637297 TYMS/DUT/UNG/DTYMK/DCTPP1/NUDT15/DNPH1 7 GO:2000781 positive regulation of double-strand break repair 7/436 40/18722 3.39560239756423e-05 0.000697623462637297 RAD51AP1/FOXM1/FUS/PRKDC/PARP1/MGMT/RIF1 7 GO:0000018 regulation of DNA recombination 11/436 107/18722 4.01104612310099e-05 0.000819160669545207 RAD51/RAD51AP1/BLM/CHEK1/MSH2/FUS/RMI2/MSH6/RPA2/PARP1/RIF1 11 GO:0071479 cellular response to ionizing radiation 9/436 72/18722 4.30903504556091e-05 0.000874810605995236 RAD51/RAD51AP1/BLM/NUCKS1/XRCC5/MGMT/TMEM109/HRAS/XRCC6 9 GO:0051382 kinetochore assembly 5/436 18/18722 4.46416885331471e-05 0.000900974313866046 CENPW/CENPN/CENPF/CENPK/CENPH 5 GO:0019692 deoxyribose phosphate metabolic process 7/436 42/18722 4.72043242803866e-05 0.000947123021087758 TYMS/DUT/UNG/DTYMK/DCTPP1/NUDT15/DNPH1 7 GO:0006334 nucleosome assembly 12/436 129/18722 4.8989946341746e-05 0.00097723549941006 ASF1B/HMGB2/CENPW/NASP/DNAJC9/CHAF1A/HAT1/NAP1L1/ANP32B/MCM2/RBBP4/SET 12 GO:0046700 heterocycle catabolic process 25/436 445/18722 4.96439502026723e-05 0.000984557185811379 FEN1/DUT/UNG/RNASEH2A/CARHSP1/NUDT8/FUS/HINT1/EXOSC9/LSM4/DCTPP1/EXOSC8/SERBP1/LSM2/NUDT1/HNRNPR/RNASEH2B/NUDT15/DNPH1/HNRNPD/MAGOHB/RNASEH2C/LSM5/BAX/YBX1 25 GO:0007098 centrosome cycle 12/436 130/18722 5.28564066196494e-05 0.00104224328225297 CDK1/BRCA1/CHEK1/NDC80/BRCA2/RANBP1/HAUS1/SAC3D1/HAUS8/NUP62/CENPJ/CEP152 12 GO:0033314 mitotic DNA replication checkpoint signaling 4/436 10/18722 5.45045484020376e-05 0.00106860060324223 CLSPN/CDC6/TOPBP1/NAE1 4 GO:0007131 reciprocal meiotic recombination 8/436 58/18722 5.60731954877196e-05 0.00108693295886082 RAD51/RAD51AP1/MND1/TOP2A/PSMC3IP/FANCD2/RAD51C/RAD21 8 GO:0140527 reciprocal homologous recombination 8/436 58/18722 5.60731954877196e-05 0.00108693295886082 RAD51/RAD51AP1/MND1/TOP2A/PSMC3IP/FANCD2/RAD51C/RAD21 8 GO:0044270 cellular nitrogen compound catabolic process 25/436 451/18722 6.15990071836094e-05 0.00118733816655598 FEN1/DUT/UNG/RNASEH2A/CARHSP1/NUDT8/FUS/HINT1/EXOSC9/LSM4/DCTPP1/EXOSC8/SERBP1/LSM2/NUDT1/HNRNPR/RNASEH2B/NUDT15/DNPH1/HNRNPD/MAGOHB/RNASEH2C/LSM5/BAX/YBX1 25 GO:0006289 nucleotide-excision repair 8/436 60/18722 7.18719848910516e-05 0.00137761329698993 HMGB1/POLD3/RPA3/BRCA2/RPA2/RPA1/HMGN1/POLR2I 8 GO:0002200 somatic diversification of immune receptors 9/436 77/18722 7.37185029628389e-05 0.00140515657591945 HMGB2/UNG/HMGB1/MSH2/MSH6/PRKDC/CTNNBL1/RIF1/HSPD1 9 GO:0090342 regulation of cell aging 8/436 61/18722 8.10595986551711e-05 0.00153654962975631 FBXO5/FOXM1/PRKDC/RBL1/CDKN2A/EEF1E1/HMGA1/YBX1 8 GO:0008156 negative regulation of DNA replication 6/436 32/18722 8.35368848223805e-05 0.00157480797706367 CDC6/BLM/GMNN/FBXO5/BRCA2/TIPIN 6 GO:0051303 establishment of chromosome localization 9/436 80/18722 9.96562990200552e-05 0.0018667350989602 CDCA5/CDT1/NUF2/CENPF/NDC80/AURKB/NUP62/KPNB1/KIF22 9 GO:1901976 regulation of cell cycle checkpoint 6/436 33/18722 0.0001001105386793 0.0018667350989602 WDR76/MAD2L1/CDT1/NDC80/RPA2/RNASEH2B 6 GO:1901361 organic cyclic compound catabolic process 26/436 495/18722 0.00010639646161446 0.00197322302594169 FEN1/DUT/UNG/RNASEH2A/YWHAH/CARHSP1/NUDT8/FUS/HINT1/EXOSC9/LSM4/DCTPP1/EXOSC8/SERBP1/LSM2/NUDT1/HNRNPR/RNASEH2B/NUDT15/DNPH1/HNRNPD/MAGOHB/RNASEH2C/LSM5/BAX/YBX1 26 GO:0019439 aromatic compound catabolic process 25/436 467/18722 0.000107082060134843 0.00197526101248734 FEN1/DUT/UNG/RNASEH2A/CARHSP1/NUDT8/FUS/HINT1/EXOSC9/LSM4/DCTPP1/EXOSC8/SERBP1/LSM2/NUDT1/HNRNPR/RNASEH2B/NUDT15/DNPH1/HNRNPD/MAGOHB/RNASEH2C/LSM5/BAX/YBX1 25 GO:0006753 nucleoside phosphate metabolic process 26/436 497/18722 0.000113516828292238 0.00208276063032443 TYMS/RRM2/RRM1/DUT/TK1/UNG/DTYMK/DHTKD1/NUDT8/GMPS/HINT1/DCTPP1/PAICS/PARP1/RAN/RNASEH2B/NUDT15/DNPH1/SLC25A1/IDH2/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 26 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 7/436 48/18722 0.000114240836033693 0.0020848952576149 PCNA/RAD51/BLM/BRCA2/MMS22L/TIPIN/NUCKS1 7 GO:0034724 DNA replication-independent nucleosome organization 6/436 34/18722 0.000119194349267891 0.00216378736686843 ASF1B/CENPW/NASP/HAT1/SUPT16H/RBBP4 6 GO:0050000 chromosome localization 9/436 82/18722 0.000120885153115395 0.00217150241015142 CDCA5/CDT1/NUF2/CENPF/NDC80/AURKB/NUP62/KPNB1/KIF22 9 GO:0072527 pyrimidine-containing compound metabolic process 9/436 82/18722 0.000120885153115395 0.00217150241015142 TYMS/RRM1/DUT/TK1/UNG/DTYMK/DCTPP1/NME1/ERH 9 GO:0090307 mitotic spindle assembly 8/436 65/18722 0.000128114404976945 0.00228937772643697 MYBL2/PRC1/KIF23/TPX2/AURKB/SMC3/KPNB1/SMC1A 8 GO:0031023 microtubule organizing center organization 12/436 143/18722 0.000132816460917739 0.00236110506429411 CDK1/BRCA1/CHEK1/NDC80/BRCA2/RANBP1/HAUS1/SAC3D1/HAUS8/NUP62/CENPJ/CEP152 12 GO:0006979 response to oxidative stress 24/436 446/18722 0.000135558568239899 0.00239743014242832 PCNA/CDK1/DHFR/EZH2/MELK/PSIP1/DHCR24/PARP1/PPIA/NUDT1/JUN/NUDT15/PPIF/PRDX2/GSTP1/MGMT/GPX8/CHCHD2/RPS3/PDLIM1/PRDX4/LDHA/HSPD1/GPX1 24 GO:0006457 protein folding 15/436 212/18722 0.000140185298194229 0.00246311331472037 PPIC/PPIA/SDF2L1/PPIF/HSP90AA1/PDIA6/HSPA8/DNAJC1/CCT5/PRDX4/PTGES3/PDIA3/HSPD1/LMAN1/ERP29 15 GO:0000731 DNA synthesis involved in DNA repair 6/436 35/18722 0.000141053656488274 0.00246311331472037 PCNA/DTL/RFC3/POLD3/POLA1/POLE2 6 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 8/436 66/18722 0.000142862008052857 0.00246311331472037 HMGB2/UNG/HMGB1/MSH2/MSH6/PRKDC/RIF1/HSPD1 8 GO:0006303 double-strand break repair via nonhomologous end joining 8/436 66/18722 0.000142862008052857 0.00246311331472037 HMGB2/HMGB1/DEK/POLA1/PRKDC/XRCC5/RIF1/XRCC6 8 GO:0016444 somatic cell DNA recombination 8/436 66/18722 0.000142862008052857 0.00246311331472037 HMGB2/UNG/HMGB1/MSH2/MSH6/PRKDC/RIF1/HSPD1 8 GO:1903311 regulation of mRNA metabolic process 18/436 288/18722 0.000152559681015379 0.00261716132781882 BARD1/CARHSP1/FUS/EXOSC9/EXOSC8/SERBP1/SRSF7/HNRNPR/SRSF2/SRSF10/HNRNPD/HSPA8/SRPK1/YBX1/RBMX/C1QBP/SRSF3/KHDRBS1 18 GO:1904666 regulation of ubiquitin protein ligase activity 5/436 23/18722 0.00015925640440161 0.00271845136070609 MAD2L1/FBXO5/UBE2C/UBE2S/RPS7 5 GO:0042769 DNA damage response, detection of DNA damage 4/436 13/18722 0.00017553650080458 0.00298151353594314 USP1/MRPS26/PARP1/RPS3 4 GO:0043484 regulation of RNA splicing 12/436 148/18722 0.000183762714380307 0.00310586144354104 FUS/SRSF7/HNRNPF/SRSF2/SRSF10/ZNF326/HSPA8/SRPK1/RBMX/C1QBP/SRSF3/KHDRBS1 12 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 5/436 24/18722 0.000197342803428651 0.00331903509099853 TYMS/DUT/UNG/DTYMK/DCTPP1 5 GO:0000910 cytokinesis 13/436 173/18722 0.000214095342605593 0.0035832249779502 CDC6/PRC1/STMN1/NUSAP1/KIF23/BRCA2/AURKB/ANLN/KIF20B/CALM2/NUP62/CKAP2/MYH10 13 GO:2000772 regulation of cellular senescence 7/436 53/18722 0.000216411839291374 0.00360441272140148 FBXO5/PRKDC/RBL1/CDKN2A/EEF1E1/HMGA1/YBX1 7 GO:0009117 nucleotide metabolic process 25/436 489/18722 0.000217890383464725 0.00361150679066411 TYMS/RRM2/RRM1/DUT/UNG/DTYMK/DHTKD1/NUDT8/GMPS/HINT1/DCTPP1/PAICS/PARP1/RAN/RNASEH2B/NUDT15/DNPH1/SLC25A1/IDH2/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 25 GO:0000281 mitotic cytokinesis 8/436 71/18722 0.000239161623248421 0.00393496650556747 STMN1/NUSAP1/KIF23/ANLN/KIF20B/NUP62/CKAP2/MYH10 8 GO:0051984 positive regulation of chromosome segregation 4/436 14/18722 0.000241244415190195 0.00393496650556747 CDC6/CDT1/AURKB/SMC6 4 GO:0006312 mitotic recombination 5/436 25/18722 0.000241992985332188 0.00393496650556747 RAD51/BRCA2/RAD51C/SMC6/TPRKB 5 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 5/436 25/18722 0.000241992985332188 0.00393496650556747 TYMS/DUT/DTYMK/DCTPP1/NME1 5 GO:0016572 histone phosphorylation 6/436 39/18722 0.000262096542757928 0.00424176055755874 CDK1/CHEK1/CCNA2/VRK1/AURKB/BAZ1B 6 GO:0051302 regulation of cell division 13/436 177/18722 0.00026790715276192 0.00431544338556877 CDC6/BLM/ORC6/PRC1/KIF23/BRCA2/AURKB/KIF20B/ASPM/CALM2/NUP62/RBL1/YBX1 13 GO:0033598 mammary gland epithelial cell proliferation 5/436 26/18722 0.000293922644447989 0.00471237660327593 BRCA2/CCND1/BAX/PHB2/GPX1 5 GO:0031297 replication fork processing 6/436 40/18722 0.000302356634307743 0.00482504935958077 PCNA/RAD51/BLM/BRCA2/MMS22L/NUCKS1 6 GO:0090398 cellular senescence 9/436 93/18722 0.000316891888617986 0.0050335929159644 FBXO5/PRKDC/SMC6/RBL1/CDKN2A/EEF1E1/HMGA1/HRAS/YBX1 9 GO:0048569 post-embryonic animal organ development 4/436 15/18722 0.000322941549164774 0.00503642025083791 HMGN1/BAX/EFEMP1/LDHA 4 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 4/436 15/18722 0.000322941549164774 0.00503642025083791 CDT1/NUF2/NDC80/AURKB 4 GO:0098760 response to interleukin-7 4/436 15/18722 0.000322941549164774 0.00503642025083791 HMGB1/YBX1/PDIA3/HSPD1 4 GO:0098761 cellular response to interleukin-7 4/436 15/18722 0.000322941549164774 0.00503642025083791 HMGB1/YBX1/PDIA3/HSPD1 4 GO:0031100 animal organ regeneration 8/436 76/18722 0.000383129310134847 0.00594803919942381 TYMS/PCNA/CDK1/CCNA2/EZH2/CDK4/GSTP1/CCND1 8 GO:0007064 mitotic sister chromatid cohesion 5/436 28/18722 0.000422640464984865 0.00650259836485682 CDCA5/DSCC1/SMC3/SMC1A/RAD21 5 GO:0090344 negative regulation of cell aging 5/436 28/18722 0.000422640464984865 0.00650259836485682 FBXO5/FOXM1/PRKDC/RBL1/YBX1 5 GO:0072331 signal transduction by p53 class mediator 12/436 163/18722 0.000447259257851312 0.00685065407896362 CHEK1/MSH2/BRCA2/FOXM1/AURKB/GTSE1/HINT1/EEF1E1/TMEM109/BAX/RPS7/PERP 12 GO:2000045 regulation of G1/S transition of mitotic cell cycle 11/436 142/18722 0.000499423079521187 0.00753935649372912 CDC6/EZH2/GTSE1/PRKDC/RPA2/RBL1/TFDP1/CCND1/CTDSPL/RDX/BRD7 11 GO:0007143 female meiotic nuclear division 5/436 29/18722 0.000501012323104121 0.00753935649372912 TOP2A/FBXO5/TTK/RAD51C/CCNB2 5 GO:0010458 exit from mitosis 5/436 29/18722 0.000501012323104121 0.00753935649372912 CDCA5/UBE2C/ANLN/UBE2S/PHB2 5 GO:0050686 negative regulation of mRNA processing 5/436 29/18722 0.000501012323104121 0.00753935649372912 BARD1/SRSF7/SRSF10/RBMX/C1QBP 5 GO:0007096 regulation of exit from mitosis 4/436 17/18722 0.000542654443940496 0.00809884968445413 CDCA5/UBE2C/ANLN/PHB2 4 GO:0061640 cytoskeleton-dependent cytokinesis 9/436 100/18722 0.000543357316930536 0.00809884968445413 STMN1/NUSAP1/KIF23/AURKB/ANLN/KIF20B/NUP62/CKAP2/MYH10 9 GO:0009416 response to light stimulus 18/436 320/18722 0.000545273761908745 0.00809884968445413 PCNA/FEN1/DTL/PBK/CHEK1/MSH2/USP1/POLD3/BRCA2/AURKB/TIPIN/MSH6/PARP1/COPS3/HMGN1/CCND1/BAX/GPX1 18 GO:0048024 regulation of mRNA splicing, via spliceosome 9/436 101/18722 0.000584483501054608 0.00863880858812213 SRSF7/SRSF2/SRSF10/HSPA8/SRPK1/RBMX/C1QBP/SRSF3/KHDRBS1 9 GO:1902806 regulation of cell cycle G1/S phase transition 12/436 168/18722 0.000586663480335895 0.00863880858812213 CDC6/EZH2/GTSE1/PRKDC/RPA2/RBL1/TFDP1/CCND1/CTDSPL/RDX/BRD7/PHB2 12 GO:0009264 deoxyribonucleotide catabolic process 5/436 30/18722 0.0005898275572907 0.00864828354301023 DUT/UNG/DCTPP1/NUDT15/DNPH1 5 GO:2001252 positive regulation of chromosome organization 8/436 82/18722 0.000641613332301409 0.00936755465160057 FEN1/CDT1/AURKB/XRCC5/HNRNPD/HNRNPA2B1/CCT5/RAD21 8 GO:0042254 ribosome biogenesis 17/436 299/18722 0.00068408424155627 0.00982239366072968 NOP56/PRKDC/EXOSC9/PA2G4/EXOSC8/RAN/RPS21/XRCC5/POP7/RPP30/RPS17/RPL35/RPL3/RPS7/RPL7A/C1QBP/RPS5 17 GO:0051782 negative regulation of cell division 4/436 18/18722 0.000684943802628311 0.00982239366072968 BLM/ORC6/AURKB/ASPM 4 GO:0006301 postreplication repair 5/436 31/18722 0.000689943710940208 0.00982239366072968 PCNA/DTL/BRCA1/MSH2/POLE2 5 GO:0046386 deoxyribose phosphate catabolic process 5/436 31/18722 0.000689943710940208 0.00982239366072968 DUT/UNG/DCTPP1/NUDT15/DNPH1 5 GO:0071168 protein localization to chromatin 5/436 31/18722 0.000689943710940208 0.00982239366072968 CDCA5/ESCO2/MSH2/EZH2/RAD21 5 GO:0071480 cellular response to gamma radiation 5/436 31/18722 0.000689943710940208 0.00982239366072968 RAD51/XRCC5/TMEM109/HRAS/XRCC6 5 GO:2001233 regulation of apoptotic signaling pathway 19/436 356/18722 0.000731046226130106 0.0103645438093074 HELLS/BRCA1/HMGB2/PARP1/PPIA/SLC25A5/PPIF/PRDX2/BCL2L12/GSTP1/ENO1/RPS3/BAX/RPS7/ITM2C/PDIA3/ERP29/GPX1/CTSH 19 GO:0051972 regulation of telomerase activity 6/436 47/18722 0.000737434545217195 0.0103852856989561 AURKB/HSP90AA1/XRCC5/HNRNPD/HNRNPA2B1/PTGES3 6 GO:0015931 nucleobase-containing compound transport 14/436 222/18722 0.000738563016772165 0.0103852856989561 SLBP/SLC29A1/NUP62/SRSF7/RAN/HNRNPA3/NXT1/SLC25A5/MAGOHB/HNRNPA2B1/YBX1/SLC25A6/SRSF3/KHDRBS1 14 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 8/436 84/18722 0.000753788784772079 0.0105561196757265 EZH2/GTSE1/PRKDC/RPA2/RBL1/CCND1/CTDSPL/BRD7 8 GO:0006335 DNA replication-dependent nucleosome assembly 5/436 32/18722 0.0008022412713324 0.0111436834086699 ASF1B/NASP/CHAF1A/HAT1/RBBP4 5 GO:0034723 DNA replication-dependent nucleosome organization 5/436 32/18722 0.0008022412713324 0.0111436834086699 ASF1B/NASP/CHAF1A/HAT1/RBBP4 5 GO:0071900 regulation of protein serine/threonine kinase activity 19/436 359/18722 0.000807958834304738 0.011177849840724 CDC6/BLM/PKMYT1/CCNE2/CCNA2/EZH2/CKS1B/HERC5/CALM2/NUP62/CCNB2/DBF4/CDKN2A/CCNE1/GSTP1/HRAS/CCND1/RPS3/ERP29 19 GO:0006401 RNA catabolic process 16/436 278/18722 0.000856373404490971 0.0118000688787491 FEN1/RNASEH2A/CARHSP1/FUS/EXOSC9/LSM4/EXOSC8/SERBP1/LSM2/HNRNPR/RNASEH2B/HNRNPD/MAGOHB/RNASEH2C/LSM5/YBX1 16 GO:0016445 somatic diversification of immunoglobulins 7/436 67/18722 0.000923723488344872 0.012677181154045 UNG/MSH2/MSH6/PRKDC/CTNNBL1/RIF1/HSPD1 7 GO:0006336 DNA replication-independent nucleosome assembly 5/436 33/18722 0.000927621759306169 0.0126799611799979 ASF1B/CENPW/NASP/HAT1/RBBP4 5 GO:0046686 response to cadmium ion 7/436 68/18722 0.00100946272690724 0.0137439151429315 PCNA/CDK1/DTYMK/MT2A/NUDT1/JUN/CYB5A 7 GO:0006220 pyrimidine nucleotide metabolic process 6/436 50/18722 0.00102918813342809 0.0139570928292165 TYMS/DUT/UNG/DTYMK/DCTPP1/NME1 6 GO:0048025 negative regulation of mRNA splicing, via spliceosome 4/436 20/18722 0.00104525133093017 0.0141191232929976 SRSF7/SRSF10/RBMX/C1QBP 4 GO:0007004 telomere maintenance via telomerase 7/436 69/18722 0.00110133668142564 0.0148183770743975 AURKB/RFC1/RPA1/HSP90AA1/XRCC5/CCT5/PTGES3 7 GO:0008608 attachment of spindle microtubules to kinetochore 5/436 35/18722 0.0012213311520249 0.016305008492597 CDT1/NUF2/NDC80/AURKB/BUB3 5 GO:0040001 establishment of mitotic spindle localization 5/436 35/18722 0.0012213311520249 0.016305008492597 MAD2L1/NUSAP1/NDC80/KPNB1/DYNLT1 5 GO:0009141 nucleoside triphosphate metabolic process 9/436 112/18722 0.00122953173339027 0.0163508658033412 TYMS/DUT/DTYMK/DCTPP1/PARP1/RAN/NUDT15/ENO1/NME1 9 GO:0031055 chromatin remodeling at centromere 3/436 10/18722 0.00133241538092449 0.0175153914634174 HELLS/CENPW/NASP 3 GO:0031125 rRNA 3'-end processing 3/436 10/18722 0.00133241538092449 0.0175153914634174 EXOSC9/EXOSC8/RPS21 3 GO:0032070 regulation of deoxyribonuclease activity 3/436 10/18722 0.00133241538092449 0.0175153914634174 PCNA/HMGB1/RPS3 3 GO:0032465 regulation of cytokinesis 8/436 92/18722 0.00137010177610385 0.0178738372388301 CDC6/PRC1/KIF23/BRCA2/AURKB/KIF20B/CALM2/NUP62 8 GO:1903312 negative regulation of mRNA metabolic process 8/436 92/18722 0.00137010177610385 0.0178738372388301 BARD1/FUS/SRSF7/SRSF10/HNRNPD/YBX1/RBMX/C1QBP 8 GO:0050684 regulation of mRNA processing 10/436 137/18722 0.00140077809469619 0.018156009815874 BARD1/SRSF7/SRSF2/SRSF10/HSPA8/SRPK1/RBMX/C1QBP/SRSF3/KHDRBS1 10 GO:0051438 regulation of ubiquitin-protein transferase activity 6/436 53/18722 0.00140231495226075 0.018156009815874 MAD2L1/FBXO5/UBE2C/UBE2S/RPS2/RPS7 6 GO:1902807 negative regulation of cell cycle G1/S phase transition 8/436 93/18722 0.00146922741257311 0.018950824257663 EZH2/GTSE1/PRKDC/RPA2/RBL1/CCND1/CTDSPL/BRD7 8 GO:0032069 regulation of nuclease activity 4/436 22/18722 0.00152110965850046 0.0194736090981906 PCNA/HMGB2/HMGB1/RPS3 4 GO:2000773 negative regulation of cellular senescence 4/436 22/18722 0.00152110965850046 0.0194736090981906 FBXO5/PRKDC/RBL1/YBX1 4 GO:0009166 nucleotide catabolic process 7/436 73/18722 0.00153629948202028 0.0195223834178206 DUT/UNG/NUDT8/HINT1/DCTPP1/NUDT15/DNPH1 7 GO:0051298 centrosome duplication 7/436 73/18722 0.00153629948202028 0.0195223834178206 BRCA1/NDC80/BRCA2/SAC3D1/NUP62/CENPJ/CEP152 7 GO:0050657 nucleic acid transport 11/436 163/18722 0.00155570381462969 0.0196236021617443 SLBP/NUP62/SRSF7/RAN/HNRNPA3/NXT1/MAGOHB/HNRNPA2B1/YBX1/SRSF3/KHDRBS1 11 GO:0050658 RNA transport 11/436 163/18722 0.00155570381462969 0.0196236021617443 SLBP/NUP62/SRSF7/RAN/HNRNPA3/NXT1/MAGOHB/HNRNPA2B1/YBX1/SRSF3/KHDRBS1 11 GO:1990830 cellular response to leukemia inhibitory factor 8/436 94/18722 0.00157395863993684 0.0197811432000853 HELLS/MYBL2/CACYBP/SRSF7/SLC25A5/XRCC5/RIF1/SRSF3 8 GO:1990823 response to leukemia inhibitory factor 8/436 95/18722 0.00168451658371561 0.0210933445209061 HELLS/MYBL2/CACYBP/SRSF7/SLC25A5/XRCC5/RIF1/SRSF3 8 GO:0046661 male sex differentiation 11/436 165/18722 0.0017145953746406 0.0213919153832432 RRM1/HMGB2/NASP/MSH2/ASPM/DHCR24/NUDT1/CTSV/CCND1/BAX/PRDX4 11 GO:0008584 male gonad development 10/436 141/18722 0.00173805067838009 0.0216059850634858 RRM1/HMGB2/NASP/MSH2/ASPM/NUDT1/CTSV/CCND1/BAX/PRDX4 10 GO:0006278 RNA-dependent DNA biosynthetic process 7/436 75/18722 0.0017987283557806 0.0221521976667744 AURKB/RFC1/RPA1/HSP90AA1/XRCC5/CCT5/PTGES3 7 GO:0051236 establishment of RNA localization 11/436 166/18722 0.00179887179410734 0.0221521976667744 SLBP/NUP62/SRSF7/RAN/HNRNPA3/NXT1/MAGOHB/HNRNPA2B1/YBX1/SRSF3/KHDRBS1 11 GO:0009162 deoxyribonucleoside monophosphate metabolic process 4/436 23/18722 0.00180781560673181 0.0221521976667744 TYMS/DUT/TK1/DNPH1 4 GO:0051131 chaperone-mediated protein complex assembly 4/436 23/18722 0.00180781560673181 0.0221521976667744 PSMG1/HSP90AA1/PTGES3/HSPD1 4 GO:0046546 development of primary male sexual characteristics 10/436 142/18722 0.00183188610253607 0.0223672641202891 RRM1/HMGB2/NASP/MSH2/ASPM/NUDT1/CTSV/CCND1/BAX/PRDX4 10 GO:0051653 spindle localization 6/436 56/18722 0.00187063044415156 0.0227593370705106 MAD2L1/NUSAP1/NDC80/ASPM/KPNB1/DYNLT1 6 GO:0009123 nucleoside monophosphate metabolic process 7/436 76/18722 0.00194233985316495 0.0234653804091864 TYMS/DUT/TK1/DTYMK/GMPS/PAICS/DNPH1 7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 7/436 76/18722 0.00194233985316495 0.0234653804091864 MSH2/BRCA2/HINT1/TMEM109/BAX/RPS7/PERP 7 GO:0036297 interstrand cross-link repair 5/436 39/18722 0.00200729211218994 0.0241649797786796 RAD51/RAD51AP1/FANCD2/MSH6/NUCKS1 5 GO:0016447 somatic recombination of immunoglobulin gene segments 6/436 57/18722 0.00205038670158846 0.0244705079677038 UNG/MSH2/MSH6/PRKDC/RIF1/HSPD1 6 GO:0071214 cellular response to abiotic stimulus 17/436 331/18722 0.00205406770466298 0.0244705079677038 PCNA/RAD51/RAD51AP1/BLM/PBK/CHEK1/POLD3/AURKB/PARP1/CASP8AP2/NUCKS1/XRCC5/MGMT/TMEM109/HRAS/BAX/XRCC6 17 GO:0104004 cellular response to environmental stimulus 17/436 331/18722 0.00205406770466298 0.0244705079677038 PCNA/RAD51/RAD51AP1/BLM/PBK/CHEK1/POLD3/AURKB/PARP1/CASP8AP2/NUCKS1/XRCC5/MGMT/TMEM109/HRAS/BAX/XRCC6 17 GO:0000302 response to reactive oxygen species 13/436 222/18722 0.00218853335971929 0.0259050061118957 PCNA/CDK1/DHFR/EZH2/JUN/NUDT15/PPIF/PRDX2/GSTP1/RPS3/LDHA/HSPD1/GPX1 13 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 8/436 99/18722 0.002189580813888 0.0259050061118957 BRCA1/MSH2/BRCA2/MSH6/PRKDC/TMEM109/RPS3/BAX 8 GO:0046034 ATP metabolic process 15/436 277/18722 0.00223150711337455 0.0263103123917116 CDK1/MSH2/DHTKD1/PARP1/PPIF/UQCC2/ENO1/HSPA8/CHCHD2/TPI1/COX5A/COX8A/LDHA/NDUFA4/PGAM1 15 GO:1902808 positive regulation of cell cycle G1/S phase transition 6/436 58/18722 0.00224288784028762 0.0263539321233795 CDC6/EZH2/TFDP1/CCND1/RDX/PHB2 6 GO:0009265 2'-deoxyribonucleotide biosynthetic process 3/436 12/18722 0.00235945792599637 0.0271654367251461 TYMS/DUT/DTYMK 3 GO:0009886 post-embryonic animal morphogenesis 3/436 12/18722 0.00235945792599637 0.0271654367251461 HMGN1/BAX/EFEMP1 3 GO:0046385 deoxyribose phosphate biosynthetic process 3/436 12/18722 0.00235945792599637 0.0271654367251461 TYMS/DUT/DTYMK 3 GO:0051095 regulation of helicase activity 3/436 12/18722 0.00235945792599637 0.0271654367251461 MSH2/MSH6/MCM2 3 GO:0051255 spindle midzone assembly 3/436 12/18722 0.00235945792599637 0.0271654367251461 PRC1/KIF23/AURKB 3 GO:1904667 negative regulation of ubiquitin protein ligase activity 3/436 12/18722 0.00235945792599637 0.0271654367251461 MAD2L1/FBXO5/RPS7 3 GO:0031099 regeneration 12/436 198/18722 0.00240825397750628 0.0276345130328563 TYMS/PCNA/CDK1/DHFR/CCNA2/EZH2/CDK4/NREP/GSTP1/CD81/CCND1/GPX1 12 GO:0062197 cellular response to chemical stress 17/436 337/18722 0.00247572328984239 0.0282831808384401 PCNA/CDK1/DHFR/EZH2/MELK/PARP1/PPIA/JUN/PPIF/XRCC5/PRDX2/MGMT/GPX8/CHCHD2/RPS3/XRCC6/GPX1 17 GO:0002181 cytoplasmic translation 10/436 148/18722 0.0024845095511121 0.0282831808384401 RPS21/RPS2/RPS17/RPL35/RPS3/RPL3/RPL27A/RPS7/RPL7A/RPS5 10 GO:0033119 negative regulation of RNA splicing 4/436 25/18722 0.00248951344016581 0.0282831808384401 SRSF7/SRSF10/RBMX/C1QBP 4 GO:0097305 response to alcohol 14/436 253/18722 0.0025387187265535 0.0287470097386305 TYMS/CDK1/RAD51/BLM/BRCA1/PARP1/CDK4/EIF4EBP1/GGH/HNRNPD/GSTP1/MGMT/CCND1/TUFM 14 GO:0048145 regulation of fibroblast proliferation 7/436 80/18722 0.00260753162615298 0.0294290822675357 CDC6/CCNA2/PRKDC/CDK4/RNASEH2B/GSTP1/BAX 7 GO:0006403 RNA localization 12/436 201/18722 0.00272521525923528 0.0305562534458701 SLBP/NUP62/SRSF7/RAN/HNRNPA3/NXT1/MAGOHB/HNRNPA2B1/YBX1/CCT5/SRSF3/KHDRBS1 12 GO:0006473 protein acetylation 12/436 201/18722 0.00272521525923528 0.0305562534458701 ESCO2/DSCC1/BRCA1/CHEK1/BRCA2/HAT1/YEATS4/SET/HINT2/POLE3/EID1/BRD7 12 GO:0048144 fibroblast proliferation 7/436 81/18722 0.00279830253562978 0.0311059514315506 CDC6/CCNA2/PRKDC/CDK4/RNASEH2B/GSTP1/BAX 7 GO:0009124 nucleoside monophosphate biosynthetic process 5/436 42/18722 0.00280143951977532 0.0311059514315506 TYMS/DUT/TK1/GMPS/PAICS 5 GO:0032467 positive regulation of cytokinesis 5/436 42/18722 0.00280143951977532 0.0311059514315506 CDC6/KIF23/AURKB/KIF20B/NUP62 5 GO:1901293 nucleoside phosphate biosynthetic process 14/436 256/18722 0.0028251019140982 0.0312674989266803 TYMS/RRM2/RRM1/DUT/TK1/DTYMK/GMPS/PAICS/PARP1/SLC25A1/IDH2/ENO1/NME1/MPC2 14 GO:0006760 folic acid-containing compound metabolic process 4/436 26/18722 0.00288871176665997 0.0318687140559818 TYMS/DHFR/MTHFD2/GGH 4 GO:0009143 nucleoside triphosphate catabolic process 3/436 13/18722 0.0030146343535539 0.032940934984634 DUT/DCTPP1/NUDT15 3 GO:0033262 regulation of nuclear cell cycle DNA replication 3/436 13/18722 0.0030146343535539 0.032940934984634 CDT1/TIPIN/DBF4 3 GO:0090501 RNA phosphodiester bond hydrolysis 10/436 152/18722 0.00301470521281699 0.032940934984634 FEN1/RNASEH2A/POLR3K/EXOSC9/EXOSC8/RPS21/TSEN34/POP7/RPP30/POLR2I 10 GO:0009116 nucleoside metabolic process 6/436 62/18722 0.00315167316846424 0.0343282242571455 TK1/DTYMK/NUDT1/DNPH1/MTAP/ERH 6 GO:1901292 nucleoside phosphate catabolic process 7/436 83/18722 0.00321177745709636 0.0348721786560051 DUT/UNG/NUDT8/HINT1/DCTPP1/NUDT15/DNPH1 7 GO:0034599 cellular response to oxidative stress 15/436 288/18722 0.00322777675495705 0.0349353376853553 PCNA/CDK1/DHFR/EZH2/MELK/PARP1/PPIA/JUN/PPIF/PRDX2/MGMT/GPX8/CHCHD2/RPS3/GPX1 15 GO:2000756 regulation of peptidyl-lysine acetylation 6/436 63/18722 0.00341644483953464 0.0368610762403879 BRCA1/CHEK1/SET/HINT2/EID1/BRD7 6 GO:0009636 response to toxic substance 14/436 262/18722 0.00347767708859041 0.0374041068681934 TYMS/CDK1/DHFR/RAD51/MT2A/CDK4/PRDX2/GSTP1/MGMT/GPX8/BAX/PRDX4/GSTO1/GPX1 14 GO:2000116 regulation of cysteine-type endopeptidase activity 13/436 235/18722 0.00357317149658762 0.0383110981399754 HMGB1/BIRC5/DHCR24/CASP8AP2/ANP32B/BCL2L12/MGMT/RPS3/BAX/PERP/HSPD1/GPX1/CTSH 13 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 12/436 209/18722 0.00373905361528282 0.039688181197171 HMGB1/BIRC5/DHCR24/CASP8AP2/ANP32B/BCL2L12/MGMT/RPS3/BAX/HSPD1/GPX1/CTSH 12 GO:0000212 meiotic spindle organization 3/436 14/18722 0.00377101342765309 0.039688181197171 FBXO5/ASPM/CCNB2 3 GO:0006287 base-excision repair, gap-filling 3/436 14/18722 0.00377101342765309 0.039688181197171 PCNA/FEN1/LIG1 3 GO:0007100 mitotic centrosome separation 3/436 14/18722 0.00377101342765309 0.039688181197171 CHEK1/RANBP1/NUP62 3 GO:0043922 negative regulation by host of viral transcription 3/436 14/18722 0.00377101342765309 0.039688181197171 JUN/NUCKS1/PSMC3 3 GO:0071481 cellular response to X-ray 3/436 14/18722 0.00377101342765309 0.039688181197171 NUCKS1/XRCC5/XRCC6 3 GO:0045910 negative regulation of DNA recombination 5/436 45/18722 0.00380104031513973 0.0398818633677199 BLM/MSH2/RMI2/MSH6/RIF1 5 GO:0007623 circadian rhythm 12/436 210/18722 0.00388471361982352 0.0406355257000442 TYMS/CDK1/TOP2A/EZH2/ID1/ID4/PRKDC/ID3/CDK4/HNRNPR/JUN/HNRNPD 12 GO:0045860 positive regulation of protein kinase activity 18/436 386/18722 0.00430732096095619 0.0449192043071146 CLSPN/CDC6/HMGB1/EZH2/CKS1B/TPX2/CALM2/PPIA/EMP2/DBF4/HSP90AA1/XRCC5/HRAS/CCND1/RPS3/XRCC6/PHB2/ERP29 18 GO:0070979 protein K11-linked ubiquitination 4/436 29/18722 0.00434412151905248 0.0451656997935426 UBE2T/UBE2C/UBE2S/ANAPC11 4 GO:0048511 rhythmic process 15/436 298/18722 0.00442651724592753 0.0458833252893575 TYMS/PCNA/CDK1/DTL/TOP2A/EZH2/ID1/ID4/PRKDC/ID3/CDK4/HNRNPR/JUN/HNRNPD/CBX3 15 GO:1901657 glycosyl compound metabolic process 7/436 88/18722 0.0044493908977987 0.0459815065371908 TK1/DTYMK/NUDT1/AKR7A2/DNPH1/MTAP/ERH 7 GO:0045911 positive regulation of DNA recombination 5/436 47/18722 0.00459495609609618 0.0472746055393834 RAD51AP1/MSH2/FUS/PARP1/RIF1 5 GO:0016446 somatic hypermutation of immunoglobulin genes 3/436 15/18722 0.00463303139727518 0.0472746055393834 UNG/MSH2/MSH6 3 GO:0051299 centrosome separation 3/436 15/18722 0.00463303139727518 0.0472746055393834 CHEK1/RANBP1/NUP62 3 GO:1905168 positive regulation of double-strand break repair via homologous recombination 3/436 15/18722 0.00463303139727518 0.0472746055393834 RAD51AP1/FUS/PARP1 3 GO:0061180 mammary gland epithelium development 6/436 67/18722 0.00464341068690534 0.0472746055393834 BRCA2/MGMT/CCND1/BAX/PHB2/GPX1 6 GO:0043543 protein acylation 13/436 243/18722 0.00473149386405477 0.0480288622709228 ESCO2/DSCC1/BRCA1/CHEK1/BRCA2/HAT1/YEATS4/ZDHHC12/SET/HINT2/POLE3/EID1/BRD7 13 GO:0009060 aerobic respiration 11/436 189/18722 0.00487594437261063 0.0493491597121742 CDK1/MSH2/DHTKD1/PPIF/FH/UQCC2/IDH2/CHCHD2/COX5A/COX8A/NDUFA4 11 GO:0006221 pyrimidine nucleotide biosynthetic process 4/436 30/18722 0.00492170520547738 0.0493753525145991 TYMS/DUT/DTYMK/NME1 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/436 30/18722 0.00492170520547738 0.0493753525145991 GTSE1/PRKDC/RPA2/CCND1 4 GO:0045070 positive regulation of viral genome replication 4/436 30/18722 0.00492170520547738 0.0493753525145991 TOP2A/HACD3/PPIA/SRPK1 4 GO:0048146 positive regulation of fibroblast proliferation 5/436 48/18722 0.00503315305867042 0.0502094172319197 CDC6/CCNA2/PRKDC/CDK4/RNASEH2B 5 GO:0034644 cellular response to UV 7/436 90/18722 0.00503411236601002 0.0502094172319197 PCNA/PBK/CHEK1/POLD3/AURKB/PARP1/BAX 7 GO:2001242 regulation of intrinsic apoptotic signaling pathway 10/436 164/18722 0.00516326822976765 0.0513483283951676 HELLS/PARP1/PPIA/PPIF/ENO1/RPS3/BAX/RPS7/ERP29/GPX1 10 GO:0006354 DNA-templated transcription, elongation 7/436 91/18722 0.00534725799458197 0.0530243993624588 CDCA4/CHEK1/EZH2/SUPT16H/ZNF326/HMGN1/POLR2I 7 GO:0097191 extrinsic apoptotic signaling pathway 12/436 219/18722 0.00541177724740927 0.0535095323800035 BRCA1/HMGB2/SIVA1/CASP8AP2/PARP2/PRDX2/BCL2L12/GSTP1/BAX/ITM2C/PDIA3/GPX1 12 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 5/436 49/18722 0.00550015300151221 0.0539172141376811 UNG/MSH2/MSH6/RIF1/HSPD1 5 GO:0002208 somatic diversification of immunoglobulins involved in immune response 5/436 49/18722 0.00550015300151221 0.0539172141376811 UNG/MSH2/MSH6/RIF1/HSPD1 5 GO:0045190 isotype switching 5/436 49/18722 0.00550015300151221 0.0539172141376811 UNG/MSH2/MSH6/RIF1/HSPD1 5 GO:0044819 mitotic G1/S transition checkpoint signaling 4/436 31/18722 0.0055486328342977 0.0540155558135137 GTSE1/PRKDC/RPA2/CCND1 4 GO:0002566 somatic diversification of immune receptors via somatic mutation 3/436 16/18722 0.00560464525491427 0.0540155558135137 UNG/MSH2/MSH6 3 GO:0090231 regulation of spindle checkpoint 3/436 16/18722 0.00560464525491427 0.0540155558135137 MAD2L1/CDT1/NDC80 3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 3/436 16/18722 0.00560464525491427 0.0540155558135137 MAD2L1/CDT1/NDC80 3 GO:1903504 regulation of mitotic spindle checkpoint 3/436 16/18722 0.00560464525491427 0.0540155558135137 MAD2L1/CDT1/NDC80 3 GO:2000001 regulation of DNA damage checkpoint 3/436 16/18722 0.00560464525491427 0.0540155558135137 WDR76/RPA2/RNASEH2B 3 GO:0006091 generation of precursor metabolites and energy 21/436 490/18722 0.00563881405750287 0.0541926359419953 CDK1/HMGB1/MSH2/DHTKD1/AKR7A2/PPIF/FH/UQCC2/IDH2/ENO1/CHCHD2/ETFB/CYB5A/TPI1/COX5A/COX8A/PTGES3/LDHA/NDUFA4/PGAM1/PHB2 21 GO:0018394 peptidyl-lysine acetylation 10/436 169/18722 0.00635174338832606 0.0608738311881193 BRCA1/CHEK1/BRCA2/HAT1/YEATS4/SET/HINT2/POLE3/EID1/BRD7 10 GO:0051101 regulation of DNA binding 8/436 118/18722 0.00639897162690595 0.0611556313423797 HMGB2/CDT1/HMGB1/ID1/CALM2/PARP1/JUN/NME1 8 GO:0032873 negative regulation of stress-activated MAPK cascade 5/436 51/18722 0.00652443448070552 0.0618379411693388 PBK/FOXM1/PPIA/GSTP1/MARVELD3 5 GO:0051293 establishment of spindle localization 5/436 51/18722 0.00652443448070552 0.0618379411693388 MAD2L1/NUSAP1/NDC80/KPNB1/DYNLT1 5 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 5/436 51/18722 0.00652443448070552 0.0618379411693388 PBK/FOXM1/PPIA/GSTP1/MARVELD3 5 GO:0006364 rRNA processing 12/436 225/18722 0.00667119704651013 0.0628799611725841 NOP56/PRKDC/EXOSC9/PA2G4/EXOSC8/RPS21/POP7/RPP30/RPS17/RPL35/RPS7/RPL7A 12 GO:0031573 mitotic intra-S DNA damage checkpoint signaling 3/436 17/18722 0.0066893575715515 0.0628799611725841 MSH2/FANCD2/TIPIN 3 GO:0033151 V(D)J recombination 3/436 17/18722 0.0066893575715515 0.0628799611725841 HMGB2/HMGB1/PRKDC 3 GO:0006839 mitochondrial transport 13/436 254/18722 0.00679828335183116 0.0635556135698439 SAE1/SLC25A5/TOMM40/PPIF/HSP90AA1/SLC25A1/MPC2/BAX/SLC25A6/VDAC1/DYNLT1/HSPD1/LMAN1 13 GO:0009165 nucleotide biosynthetic process 13/436 254/18722 0.00679828335183116 0.0635556135698439 TYMS/RRM2/RRM1/DUT/DTYMK/GMPS/PAICS/PARP1/SLC25A1/IDH2/ENO1/NME1/MPC2 13 GO:0042558 pteridine-containing compound metabolic process 4/436 33/18722 0.00695759456669975 0.0646924307814278 TYMS/DHFR/MTHFD2/GGH 4 GO:0071353 cellular response to interleukin-4 4/436 33/18722 0.00695759456669975 0.0646924307814278 TUBA1B/CDK4/MCM2/RPL3 4 GO:0042274 ribosomal small subunit biogenesis 6/436 73/18722 0.00705271945090307 0.0649837185637222 PRKDC/RPS21/XRCC5/RPS17/RPS7/RPS5 6 GO:0002218 activation of innate immune response 5/436 52/18722 0.00708362306698692 0.0649837185637222 HMGB1/PRKDC/HSP90AA1/XRCC5/XRCC6 5 GO:0007129 homologous chromosome pairing at meiosis 5/436 52/18722 0.00708362306698692 0.0649837185637222 CCNE2/PSMC3IP/FANCD2/CCNE1/RAD21 5 GO:0032206 positive regulation of telomere maintenance 5/436 52/18722 0.00708362306698692 0.0649837185637222 AURKB/XRCC5/HNRNPD/HNRNPA2B1/CCT5 5 GO:0072523 purine-containing compound catabolic process 5/436 52/18722 0.00708362306698692 0.0649837185637222 NUDT8/HINT1/NUDT1/NUDT15/DNPH1 5 GO:0042542 response to hydrogen peroxide 9/436 146/18722 0.00726872066039467 0.0665039482288377 PCNA/CDK1/EZH2/JUN/PPIF/RPS3/LDHA/HSPD1/GPX1 9 GO:0006635 fatty acid beta-oxidation 6/436 74/18722 0.00752823929621764 0.0686951835779859 ACAT2/HADH/SLC27A2/ECI1/ETFB/ECHS1 6 GO:0009112 nucleobase metabolic process 4/436 34/18722 0.00774300640285709 0.070281097799478 TYMS/RRM1/GMPS/PAICS 4 GO:0051973 positive regulation of telomerase activity 4/436 34/18722 0.00774300640285709 0.070281097799478 AURKB/HSP90AA1/XRCC5/PTGES3 4 GO:0031109 microtubule polymerization or depolymerization 8/436 122/18722 0.0077779320863305 0.0704118337419523 FBXO5/STMN1/SKA3/TPX2/CENPJ/CKAP2/SKA2/RPS3 8 GO:0006337 nucleosome disassembly 3/436 18/18722 0.00789024032533613 0.0712405646216534 SUPT16H/SET/HMGA1 3 GO:0035065 regulation of histone acetylation 5/436 54/18722 0.00830076145408281 0.0747504266376853 BRCA1/CHEK1/SET/EID1/BRD7 5 GO:0006165 nucleoside diphosphate phosphorylation 7/436 99/18722 0.00840375334532387 0.0754400047698003 DTYMK/DHTKD1/ENO1/NME1/TPI1/LDHA/PGAM1 7 GO:0006402 mRNA catabolic process 12/436 232/18722 0.00842131210341985 0.0754400047698003 CARHSP1/FUS/EXOSC9/LSM4/EXOSC8/SERBP1/LSM2/HNRNPR/HNRNPD/MAGOHB/LSM5/YBX1 12 GO:0000460 maturation of 5.8S rRNA 4/436 35/18722 0.00858451288683545 0.0763043101417938 PRKDC/EXOSC9/EXOSC8/RPS21 4 GO:0072528 pyrimidine-containing compound biosynthetic process 4/436 35/18722 0.00858451288683545 0.0763043101417938 TYMS/DUT/DTYMK/NME1 4 GO:0097421 liver regeneration 4/436 35/18722 0.00858451288683545 0.0763043101417938 TYMS/PCNA/EZH2/CCND1 4 GO:0009062 fatty acid catabolic process 7/436 100/18722 0.00886071204032331 0.0785558217321687 ACAT2/NUDT8/HADH/SLC27A2/ECI1/ETFB/ECHS1 7 GO:0051053 negative regulation of DNA metabolic process 8/436 125/18722 0.0089504530966298 0.0791469190065382 BLM/MSH2/RMI2/MSH6/PARP1/XRCC5/RPS3/RIF1 8 GO:0072521 purine-containing compound metabolic process 18/436 416/18722 0.00908509005976771 0.0795953780195962 DHTKD1/NUDT8/GMPS/HINT1/PAICS/PARP1/NUDT1/RAN/NUDT15/DNPH1/MTAP/SLC25A1/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 18 GO:1901983 regulation of protein acetylation 6/436 77/18722 0.0090933010473722 0.0795953780195962 BRCA1/CHEK1/SET/HINT2/EID1/BRD7 6 GO:0017038 protein import 11/436 206/18722 0.00910778491850377 0.0795953780195962 CDK1/NUP62/KPNB1/RAN/NXT1/TOMM40/HSP90AA1/HSPA8/CSE1L/HSPD1/PHB2 11 GO:0000028 ribosomal small subunit assembly 3/436 19/18722 0.00920995775977257 0.0795953780195962 PRKDC/XRCC5/RPS5 3 GO:0002902 regulation of B cell apoptotic process 3/436 19/18722 0.00920995775977257 0.0795953780195962 AURKB/BAX/SLC39A10 3 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 3/436 19/18722 0.00920995775977257 0.0795953780195962 TYMS/DTYMK/NME1 3 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 3/436 19/18722 0.00920995775977257 0.0795953780195962 DUT/UNG/DCTPP1 3 GO:0046653 tetrahydrofolate metabolic process 3/436 19/18722 0.00920995775977257 0.0795953780195962 TYMS/DHFR/MTHFD2 3 GO:0051444 negative regulation of ubiquitin-protein transferase activity 3/436 19/18722 0.00920995775977257 0.0795953780195962 MAD2L1/FBXO5/RPS7 3 GO:0046939 nucleotide phosphorylation 7/436 101/18722 0.00933563929052866 0.0802141944745538 DTYMK/DHTKD1/ENO1/NME1/TPI1/LDHA/PGAM1 7 GO:0098869 cellular oxidant detoxification 7/436 101/18722 0.00933563929052866 0.0802141944745538 DHFR/PRDX2/GSTP1/GPX8/PRDX4/GSTO1/GPX1 7 GO:0016573 histone acetylation 9/436 152/18722 0.00935169856887832 0.0802141944745538 BRCA1/CHEK1/BRCA2/HAT1/YEATS4/SET/POLE3/EID1/BRD7 9 GO:0070670 response to interleukin-4 4/436 36/18722 0.00948363314803953 0.0811430058127772 TUBA1B/CDK4/MCM2/RPL3 4 GO:0016072 rRNA metabolic process 12/436 236/18722 0.00957144427243841 0.0816906101958612 NOP56/PRKDC/EXOSC9/PA2G4/EXOSC8/RPS21/POP7/RPP30/RPS17/RPL35/RPS7/RPL7A 12 GO:0043388 positive regulation of DNA binding 5/436 56/18722 0.00965561954233534 0.0822045425552172 HMGB2/HMGB1/CALM2/PARP1/NME1 5 GO:1990542 mitochondrial transmembrane transport 7/436 102/18722 0.00982892928293073 0.0834729118062756 SLC25A5/TOMM40/SLC25A1/MPC2/SLC25A6/VDAC1/HSPD1 7 GO:0051168 nuclear export 9/436 154/18722 0.0101375687315761 0.0858814773284876 BARD1/NUP62/RAN/ANP32B/NXT1/CSE1L/HNRNPA2B1/SRSF3/KHDRBS1 9 GO:0000245 spliceosomal complex assembly 6/436 79/18722 0.0102578222014588 0.0866861772739043 SNRPD1/PSIP1/SNRPG/SNRPE/SRSF10/SRPK1 6 GO:0006611 protein export from nucleus 5/436 57/18722 0.0103868919308687 0.0873466328794376 BARD1/RAN/ANP32B/NXT1/CSE1L 5 GO:0051785 positive regulation of nuclear division 5/436 57/18722 0.0103868919308687 0.0873466328794376 RAD51AP1/CDT1/NUSAP1/NUP62/ANAPC11 5 GO:0031396 regulation of protein ubiquitination 11/436 210/18722 0.0104266777232554 0.0873801660165263 MAD2L1/BRCA1/FANCI/FBXO5/UBE2C/UBE2S/PPIA/HSP90AA1/RPS2/RPS3/RPS7 11 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 4/436 37/18722 0.0104418152336857 0.0873801660165263 AURKB/XRCC5/HNRNPA2B1/CCT5 4 GO:0031498 chromatin disassembly 3/436 20/18722 0.0106507883060389 0.0884814883245021 SUPT16H/SET/HMGA1 3 GO:0032986 protein-DNA complex disassembly 3/436 20/18722 0.0106507883060389 0.0884814883245021 SUPT16H/SET/HMGA1 3 GO:2000757 negative regulation of peptidyl-lysine acetylation 3/436 20/18722 0.0106507883060389 0.0884814883245021 BRCA1/SET/HINT2 3 GO:0032204 regulation of telomere maintenance 6/436 80/18722 0.010878116031889 0.0901517297232152 AURKB/PARP1/XRCC5/HNRNPD/HNRNPA2B1/CCT5 6 GO:0043467 regulation of generation of precursor metabolites and energy 8/436 130/18722 0.0111912519151051 0.0925233381222304 CDK1/HMGB1/PPIF/UQCC2/CHCHD2/NDUFA4/PGAM1/PHB2 8 GO:0040029 regulation of gene expression, epigenetic 7/436 105/18722 0.0114228871807571 0.0942113603778307 HELLS/BRCA1/CDCA4/CHEK1/EZH2/POLE3/GPX1 7 GO:0071398 cellular response to fatty acid 4/436 38/18722 0.0114604347799467 0.0942943686570672 ID3/CDK4/XRCC5/NME1 4 GO:1903320 regulation of protein modification by small protein conjugation or removal 12/436 242/18722 0.011521293085707 0.094568317170002 MAD2L1/BRCA1/FANCI/FBXO5/UBE2C/UBE2S/PPIA/SAE1/HSP90AA1/RPS2/RPS3/RPS7 12 GO:0034470 ncRNA processing 17/436 395/18722 0.0116005312959396 0.0949914627120976 NOP56/PRKDC/POLR3K/EXOSC9/PA2G4/EXOSC8/RPS21/TSEN34/POP7/RPP30/LAGE3/RPS17/HNRNPA2B1/RPL35/TPRKB/RPS7/RPL7A 17 GO:0019079 viral genome replication 8/436 131/18722 0.0116849981826515 0.0954553065825648 TOP2A/DEK/HACD3/PPIA/NUCKS1/HSPA8/SRPK1/ILF3 8 GO:0018393 internal peptidyl-lysine acetylation 9/436 158/18722 0.0118572660860927 0.0966324939225274 BRCA1/CHEK1/BRCA2/HAT1/YEATS4/SET/POLE3/EID1/BRD7 9 GO:0001836 release of cytochrome c from mitochondria 5/436 59/18722 0.0119613514419088 0.0972497554435761 GGCT/JUN/PPIF/BAX/GPX1 5 GO:0006090 pyruvate metabolic process 7/436 106/18722 0.0119935274161701 0.0972808334867131 DHTKD1/ENO1/MPC2/TPI1/VDAC1/LDHA/PGAM1 7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 6/436 82/18722 0.0121975201313515 0.0974615094503208 FEN1/RNASEH2A/RPS21/TSEN34/POP7/RPP30 6 GO:0006244 pyrimidine nucleotide catabolic process 3/436 21/18722 0.0122146456029257 0.0974615094503208 DUT/UNG/DCTPP1 3 GO:0007063 regulation of sister chromatid cohesion 3/436 21/18722 0.0122146456029257 0.0974615094503208 FEN1/CDCA5/RAD21 3 GO:0019985 translesion synthesis 3/436 21/18722 0.0122146456029257 0.0974615094503208 PCNA/DTL/POLE2 3 GO:0031145 anaphase-promoting complex-dependent catabolic process 3/436 21/18722 0.0122146456029257 0.0974615094503208 UBE2C/UBE2S/ANAPC11 3 GO:0046599 regulation of centriole replication 3/436 21/18722 0.0122146456029257 0.0974615094503208 BRCA1/NUP62/CENPJ 3 GO:2000774 positive regulation of cellular senescence 3/436 21/18722 0.0122146456029257 0.0974615094503208 CDKN2A/EEF1E1/HMGA1 3 GO:0009410 response to xenobiotic stimulus 19/436 462/18722 0.0123766299761783 0.0985248664692989 TYMS/PCNA/CDK1/RAD51/MCM7/CENPF/HADH/JUN/VKORC1/NUDT15/XRCC5/GGH/GSTP1/MGMT/NME1/LDHA/HSPD1/GSTO1/GPX1 19 GO:0032506 cytokinetic process 4/436 39/18722 0.012540793941976 0.0996006111456474 AURKB/ANLN/KIF20B/NUP62 4 GO:0008637 apoptotic mitochondrial changes 7/436 107/18722 0.0125844668230859 0.0997166412702257 GGCT/JUN/SLC25A5/PPIF/BAX/HSPD1/GPX1 7 GO:0006475 internal protein amino acid acetylation 9/436 160/18722 0.0127946343201442 0.101148364867315 BRCA1/CHEK1/BRCA2/HAT1/YEATS4/SET/POLE3/EID1/BRD7 9 GO:0006405 RNA export from nucleus 6/436 84/18722 0.0136255907106211 0.107469889030209 NUP62/RAN/NXT1/HNRNPA2B1/SRSF3/KHDRBS1 6 GO:0042255 ribosome assembly 5/436 61/18722 0.0136904219441509 0.107487042769753 PRKDC/XRCC5/RPL3/C1QBP/RPS5 5 GO:1904356 regulation of telomere maintenance via telomere lengthening 5/436 61/18722 0.0136904219441509 0.107487042769753 AURKB/PARP1/XRCC5/HNRNPA2B1/CCT5 5 GO:0033674 positive regulation of kinase activity 19/436 467/18722 0.013728170734167 0.107537337417641 CLSPN/CDC6/HMGB1/EZH2/CKS1B/TPX2/CALM2/PPIA/EMP2/DBF4/HSP90AA1/XRCC5/CD81/HRAS/CCND1/RPS3/XRCC6/PHB2/ERP29 19 GO:0048732 gland development 18/436 436/18722 0.0141554248906753 0.110631578131906 TYMS/PCNA/EZH2/BRCA2/PRKDC/SLC29A1/CCNB2/PRDX2/HNRNPD/MGMT/LY6E/NME1/HRAS/CCND1/BAX/WLS/PHB2/GPX1 18 GO:0010038 response to metal ion 16/436 373/18722 0.0144843820642884 0.112945261051303 PCNA/CDK1/DTYMK/MT2A/FUS/CALM2/PARP1/CDK4/CACYBP/NUDT1/JUN/PPIF/GGH/HNRNPD/CCND1/CYB5A 16 GO:0008406 gonad development 11/436 221/18722 0.0148134313481995 0.115249167699938 RRM1/HMGB2/NASP/MSH2/BRCA2/ASPM/NUDT1/CTSV/CCND1/BAX/PRDX4 11 GO:0007099 centriole replication 4/436 41/18722 0.0148915675896179 0.115594951131174 BRCA1/NUP62/CENPJ/CEP152 4 GO:0030879 mammary gland development 8/436 137/18722 0.0149905140176554 0.115838859447243 BRCA2/SLC29A1/MGMT/NME1/CCND1/BAX/PHB2/GPX1 8 GO:0045471 response to ethanol 8/436 137/18722 0.0149905140176554 0.115838859447243 TYMS/CDK1/EIF4EBP1/GGH/GSTP1/MGMT/CCND1/TUFM 8 GO:0018205 peptidyl-lysine modification 16/436 376/18722 0.0155097932794071 0.119582248857631 BRCA1/CHEK1/EZH2/BRCA2/HINT1/HAT1/SAE1/YEATS4/GCSH/SET/HINT2/POLE3/EID1/SUZ12/RIF1/BRD7 16 GO:0045143 homologous chromosome segregation 5/436 63/18722 0.0155802553800726 0.119856179840872 CCNE2/PSMC3IP/FANCD2/CCNE1/RAD21 5 GO:0042026 protein refolding 3/436 23/18722 0.0157173911027898 0.120640646249825 HSP90AA1/HSPA8/HSPD1 3 GO:0033574 response to testosterone 4/436 42/18722 0.0161642126496013 0.123793333930317 NASP/CDK4/MTAP/NME1 4 GO:2001234 negative regulation of apoptotic signaling pathway 11/436 224/18722 0.0162213728304191 0.123954410203046 HELLS/BRCA1/HMGB2/PPIA/SLC25A5/PPIF/PRDX2/GSTP1/ENO1/BAX/GPX1 11 GO:0031110 regulation of microtubule polymerization or depolymerization 6/436 88/18722 0.0168242799788515 0.128275788016533 STMN1/SKA3/TPX2/CKAP2/SKA2/RPS3 6 GO:0006458 'de novo' protein folding 4/436 43/18722 0.0175030578924117 0.131650075482526 SDF2L1/HSPA8/PTGES3/HSPD1 4 GO:0045840 positive regulation of mitotic nuclear division 4/436 43/18722 0.0175030578924117 0.131650075482526 CDT1/NUSAP1/NUP62/ANAPC11 4 GO:0006119 oxidative phosphorylation 8/436 141/18722 0.0175413159523434 0.131650075482526 CDK1/MSH2/PPIF/UQCC2/CHCHD2/COX5A/COX8A/NDUFA4 8 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3/436 24/18722 0.0176584598078466 0.131650075482526 EXOSC9/EXOSC8/RPS21 3 GO:0001783 B cell apoptotic process 3/436 24/18722 0.0176584598078466 0.131650075482526 AURKB/BAX/SLC39A10 3 GO:0006213 pyrimidine nucleoside metabolic process 3/436 24/18722 0.0176584598078466 0.131650075482526 TK1/DTYMK/ERH 3 GO:0010155 regulation of proton transport 3/436 24/18722 0.0176584598078466 0.131650075482526 PPIF/NDUFA4/PHB2 3 GO:0072530 purine-containing compound transmembrane transport 3/436 24/18722 0.0176584598078466 0.131650075482526 SLC29A1/SLC25A5/SLC25A6 3 GO:0090343 positive regulation of cell aging 3/436 24/18722 0.0176584598078466 0.131650075482526 CDKN2A/EEF1E1/HMGA1 3 GO:1901984 negative regulation of protein acetylation 3/436 24/18722 0.0176584598078466 0.131650075482526 BRCA1/SET/HINT2 3 GO:0051781 positive regulation of cell division 6/436 89/18722 0.0176982070825582 0.131650075482526 CDC6/KIF23/AURKB/KIF20B/NUP62/YBX1 6 GO:0045137 development of primary sexual characteristics 11/436 227/18722 0.0177272908402586 0.131650075482526 RRM1/HMGB2/NASP/MSH2/BRCA2/ASPM/NUDT1/CTSV/CCND1/BAX/PRDX4 11 GO:0016032 viral process 17/436 415/18722 0.0179998680288772 0.133385631116798 CDK1/TOP2A/DEK/SIVA1/HACD3/PPIA/RAN/JUN/NUCKS1/HSPA8/LY6E/PSMC3/CD81/SRPK1/ILF3/DYNLT1/PHB2 17 GO:0033157 regulation of intracellular protein transport 11/436 229/18722 0.0187875557566161 0.138922637502047 CDK1/BARD1/KIF20B/NUP62/RAN/ANP32B/SAE1/SVIP/CD81/HRAS/LMAN1 11 GO:0044403 biological process involved in symbiotic interaction 13/436 290/18722 0.0188732784547053 0.138988550148426 CDK1/SIVA1/PPIA/JUN/NUCKS1/HSPA8/LY6E/PSMC3/CD81/DYNLT1/HSPD1/PHB2/GPX1 13 GO:1990748 cellular detoxification 7/436 116/18722 0.018877488886379 0.138988550148426 DHFR/PRDX2/GSTP1/GPX8/PRDX4/GSTO1/GPX1 7 GO:0045333 cellular respiration 11/436 230/18722 0.0193350051160269 0.142052253861002 CDK1/MSH2/DHTKD1/PPIF/FH/UQCC2/IDH2/CHCHD2/COX5A/COX8A/NDUFA4 11 GO:0051099 positive regulation of binding 9/436 173/18722 0.020281688116812 0.148689042582868 GMNN/HMGB2/CDT1/STMN1/HMGB1/CALM2/PARP1/RAN/NME1 9 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 4/436 45/18722 0.020382980174014 0.148795755270302 MELK/PARP1/PPIA/GPX1 4 GO:0098534 centriole assembly 4/436 45/18722 0.020382980174014 0.148795755270302 BRCA1/NUP62/CENPJ/CEP152 4 GO:0006413 translational initiation 7/436 118/18722 0.0205298117050415 0.14954943515923 EIF1AY/EIF4EBP1/RPS17/RPS3/EIF1AX/KHDRBS1/RPS5 7 GO:0006283 transcription-coupled nucleotide-excision repair 2/436 10/18722 0.0215158244601394 0.153793320255704 HMGN1/POLR2I 2 GO:0009113 purine nucleobase biosynthetic process 2/436 10/18722 0.0215158244601394 0.153793320255704 GMPS/PAICS 2 GO:0010992 ubiquitin recycling 2/436 10/18722 0.0215158244601394 0.153793320255704 UBE2C/UBE2S 2 GO:0030953 astral microtubule organization 2/436 10/18722 0.0215158244601394 0.153793320255704 KPNB1/CENPJ 2 GO:0035999 tetrahydrofolate interconversion 2/436 10/18722 0.0215158244601394 0.153793320255704 TYMS/MTHFD2 2 GO:0050861 positive regulation of B cell receptor signaling pathway 2/436 10/18722 0.0215158244601394 0.153793320255704 CD81/SLC39A10 2 GO:1901524 regulation of mitophagy 2/436 10/18722 0.0215158244601394 0.153793320255704 SLC25A5/VDAC1 2 GO:1901978 positive regulation of cell cycle checkpoint 2/436 10/18722 0.0215158244601394 0.153793320255704 MAD2L1/NDC80 2 GO:1904668 positive regulation of ubiquitin protein ligase activity 2/436 10/18722 0.0215158244601394 0.153793320255704 UBE2C/UBE2S 2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 3/436 26/18722 0.0219232447631775 0.155749533320783 CD81/RPS3/SLC39A10 3 GO:0006195 purine nucleotide catabolic process 4/436 46/18722 0.0219256848131559 0.155749533320783 NUDT8/HINT1/NUDT15/DNPH1 4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 4/436 46/18722 0.0219256848131559 0.155749533320783 CDC6/TFDP1/CCND1/RDX 4 GO:0006368 transcription elongation from RNA polymerase II promoter 5/436 69/18722 0.0222699394079702 0.15761585836036 CDCA4/CHEK1/EZH2/SUPT16H/POLR2I 5 GO:0006304 DNA modification 7/436 120/18722 0.0222802947551077 0.15761585836036 HELLS/BRCA1/UNG/EZH2/PARP1/PARP2/MGMT 7 GO:0051702 biological process involved in interaction with symbiont 6/436 94/18722 0.0225365298176901 0.159100481079207 JUN/NUCKS1/HSPA8/PSMC3/HSPD1/GPX1 6 GO:2001056 positive regulation of cysteine-type endopeptidase activity 8/436 148/18722 0.0227318727829383 0.160150011331132 HMGB1/CASP8AP2/ANP32B/RPS3/BAX/PERP/HSPD1/CTSH 8 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 5/436 70/18722 0.023540203681629 0.165504997605879 UNG/MSH2/MSH6/RIF1/HSPD1 5 GO:0051098 regulation of binding 15/436 363/18722 0.0236227434416537 0.165745670241951 GMNN/HMGB2/CDT1/STMN1/HMGB1/AURKB/ID1/CALM2/PARP1/RAN/JUN/NUCKS1/NME1/BAX/LRPAP1 15 GO:0006163 purine nucleotide metabolic process 16/436 396/18722 0.0238522984033865 0.167014766983712 DHTKD1/NUDT8/GMPS/HINT1/PAICS/PARP1/RAN/NUDT15/DNPH1/SLC25A1/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 16 GO:0072329 monocarboxylic acid catabolic process 7/436 122/18722 0.0241314533613341 0.168430007407637 ACAT2/NUDT8/HADH/SLC27A2/ECI1/ETFB/ECHS1 7 GO:0000469 cleavage involved in rRNA processing 3/436 27/18722 0.0242474563332687 0.168430007407637 EXOSC9/EXOSC8/RPS21 3 GO:0009651 response to salt stress 3/436 27/18722 0.0242474563332687 0.168430007407637 XRCC5/BAX/XRCC6 3 GO:0016570 histone modification 18/436 463/18722 0.0242507792653373 0.168430007407637 CDK1/BRCA1/CHEK1/CCNA2/EZH2/VRK1/BRCA2/AURKB/HAT1/PARP2/BAZ1B/YEATS4/SET/POLE3/EID1/SUZ12/RIF1/BRD7 18 GO:0071482 cellular response to light stimulus 7/436 123/18722 0.0250955425556317 0.173945063653278 PCNA/PBK/CHEK1/POLD3/AURKB/PARP1/BAX 7 GO:2001236 regulation of extrinsic apoptotic signaling pathway 8/436 151/18722 0.0252572051190995 0.174563066256826 BRCA1/HMGB2/PRDX2/BCL2L12/GSTP1/ITM2C/PDIA3/GPX1 8 GO:0007144 female meiosis I 2/436 11/18722 0.0258969981710069 0.174563066256826 FBXO5/CCNB2 2 GO:0009120 deoxyribonucleoside metabolic process 2/436 11/18722 0.0258969981710069 0.174563066256826 TK1/DTYMK 2 GO:0009155 purine deoxyribonucleotide catabolic process 2/436 11/18722 0.0258969981710069 0.174563066256826 NUDT15/DNPH1 2 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 2/436 11/18722 0.0258969981710069 0.174563066256826 ATP1B3/BAX 2 GO:0033197 response to vitamin E 2/436 11/18722 0.0258969981710069 0.174563066256826 SRSF2/CCND1 2 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 2/436 11/18722 0.0258969981710069 0.174563066256826 EXOSC9/EXOSC8 2 GO:0035404 histone-serine phosphorylation 2/436 11/18722 0.0258969981710069 0.174563066256826 VRK1/AURKB 2 GO:0044771 meiotic cell cycle phase transition 2/436 11/18722 0.0258969981710069 0.174563066256826 TTK/CCNB2 2 GO:0048096 chromatin-mediated maintenance of transcription 2/436 11/18722 0.0258969981710069 0.174563066256826 CDCA4/CHEK1 2 GO:0048102 autophagic cell death 2/436 11/18722 0.0258969981710069 0.174563066256826 CTSV/PHB2 2 GO:0051574 positive regulation of histone H3-K9 methylation 2/436 11/18722 0.0258969981710069 0.174563066256826 BRCA1/RIF1 2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 2/436 11/18722 0.0258969981710069 0.174563066256826 CALM2/GSTO1 2 GO:2000615 regulation of histone H3-K9 acetylation 2/436 11/18722 0.0258969981710069 0.174563066256826 BRCA1/CHEK1 2 GO:0009132 nucleoside diphosphate metabolic process 7/436 124/18722 0.0260856943932352 0.175146805211722 DTYMK/DHTKD1/ENO1/NME1/TPI1/LDHA/PGAM1 7 GO:0097237 cellular response to toxic substance 7/436 124/18722 0.0260856943932352 0.175146805211722 DHFR/PRDX2/GSTP1/GPX8/PRDX4/GSTO1/GPX1 7 GO:0098754 detoxification 8/436 152/18722 0.0261408443718896 0.175174291093658 DHFR/MT2A/PRDX2/GSTP1/GPX8/PRDX4/GSTO1/GPX1 8 GO:0006417 regulation of translation 18/436 468/18722 0.0266063688616444 0.177875475504392 TYMS/DHFR/TCOF1/PRKDC/EXOSC9/PA2G4/EXOSC8/CDK4/HNRNPR/EIF4EBP1/HNRNPD/UQCC2/DNAJC1/RPS3/ILF3/YBX1/C1QBP/KHDRBS1 18 GO:0000423 mitophagy 3/436 28/18722 0.0266994665942179 0.177875475504392 SLC25A5/VDAC1/PHB2 3 GO:0051503 adenine nucleotide transport 3/436 28/18722 0.0266994665942179 0.177875475504392 SLC29A1/SLC25A5/SLC25A6 3 GO:0051445 regulation of meiotic cell cycle 4/436 49/18722 0.026972973727267 0.179349366004367 RAD51AP1/FBXO5/TTK/ASPM 4 GO:0043628 ncRNA 3'-end processing 4/436 50/18722 0.0287969778013126 0.190819645788058 POLR3K/EXOSC9/EXOSC8/RPS21 4 GO:0007548 sex differentiation 12/436 276/18722 0.0288562526772998 0.190819645788058 RRM1/HMGB2/NASP/MSH2/BRCA2/ASPM/DHCR24/NUDT1/CTSV/CCND1/BAX/PRDX4 12 GO:0034614 cellular response to reactive oxygen species 8/436 155/18722 0.0289204942610873 0.190819645788058 PCNA/CDK1/DHFR/EZH2/JUN/PPIF/PRDX2/RPS3 8 GO:0046434 organophosphate catabolic process 8/436 155/18722 0.0289204942610873 0.190819645788058 DUT/UNG/NUDT8/IMPA2/HINT1/DCTPP1/NUDT15/DNPH1 8 GO:0015868 purine ribonucleotide transport 3/436 29/18722 0.0292789294875063 0.190981002037327 SLC29A1/SLC25A5/SLC25A6 3 GO:0021591 ventricular system development 3/436 29/18722 0.0292789294875063 0.190981002037327 CENPF/ANP32B/C12orf57 3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 3/436 29/18722 0.0292789294875063 0.190981002037327 CDC6/CKS1B/CCND1 3 GO:0070198 protein localization to chromosome, telomeric region 3/436 29/18722 0.0292789294875063 0.190981002037327 BRCA2/XRCC5/CCT5 3 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/436 29/18722 0.0292789294875063 0.190981002037327 PARP1/PPIA/GPX1 3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 3/436 29/18722 0.0292789294875063 0.190981002037327 DEK/PRKDC/RIF1 3 GO:0043627 response to estrogen 5/436 75/18722 0.0305887137243671 0.195538288344229 BRCA1/DTYMK/CCND1/LDHA/HSPD1 5 GO:0002424 T cell mediated immune response to tumor cell 2/436 12/18722 0.030604506220009 0.195538288344229 HMGB1/HSPD1 2 GO:0002903 negative regulation of B cell apoptotic process 2/436 12/18722 0.030604506220009 0.195538288344229 AURKB/SLC39A10 2 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 2/436 12/18722 0.030604506220009 0.195538288344229 TYMS/DUT 2 GO:0010623 programmed cell death involved in cell development 2/436 12/18722 0.030604506220009 0.195538288344229 PRKDC/BAX 2 GO:0043471 regulation of cellular carbohydrate catabolic process 2/436 12/18722 0.030604506220009 0.195538288344229 HMGB1/PGAM1 2 GO:0070213 protein auto-ADP-ribosylation 2/436 12/18722 0.030604506220009 0.195538288344229 PARP1/PARP2 2 GO:0071472 cellular response to salt stress 2/436 12/18722 0.030604506220009 0.195538288344229 XRCC5/XRCC6 2 GO:0072711 cellular response to hydroxyurea 2/436 12/18722 0.030604506220009 0.195538288344229 RAD51/BLM 2 GO:1903599 positive regulation of autophagy of mitochondrion 2/436 12/18722 0.030604506220009 0.195538288344229 SLC25A5/VDAC1 2 GO:2000105 positive regulation of DNA-dependent DNA replication 2/436 12/18722 0.030604506220009 0.195538288344229 CDT1/DBF4 2 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7/436 129/18722 0.0314370267862788 0.20048408718164 HMGB1/CASP8AP2/ANP32B/RPS3/BAX/HSPD1/CTSH 7 GO:0043488 regulation of mRNA stability 8/436 158/18722 0.0318977234193722 0.201969522119701 CARHSP1/FUS/EXOSC9/EXOSC8/SERBP1/HNRNPR/HNRNPD/YBX1 8 GO:0000132 establishment of mitotic spindle orientation 3/436 30/18722 0.0319852877410651 0.201969522119701 MAD2L1/NDC80/DYNLT1 3 GO:0006099 tricarboxylic acid cycle 3/436 30/18722 0.0319852877410651 0.201969522119701 DHTKD1/FH/IDH2 3 GO:0015865 purine nucleotide transport 3/436 30/18722 0.0319852877410651 0.201969522119701 SLC29A1/SLC25A5/SLC25A6 3 GO:0044788 modulation by host of viral process 3/436 30/18722 0.0319852877410651 0.201969522119701 NUCKS1/HSPA8/PSMC3 3 GO:0006305 DNA alkylation 5/436 76/18722 0.0321408799409376 0.201969522119701 HELLS/BRCA1/EZH2/PARP1/MGMT 5 GO:0006306 DNA methylation 5/436 76/18722 0.0321408799409376 0.201969522119701 HELLS/BRCA1/EZH2/PARP1/MGMT 5 GO:0032543 mitochondrial translation 5/436 76/18722 0.0321408799409376 0.201969522119701 UQCC2/MRPS34/C1QBP/TUFM/MRPL57 5 GO:0051028 mRNA transport 7/436 130/18722 0.0325892253561829 0.204412490305418 SLBP/NUP62/SRSF7/HNRNPA3/MAGOHB/HNRNPA2B1/SRSF3 7 GO:0019395 fatty acid oxidation 6/436 103/18722 0.0333415059443127 0.208749465136746 ACAT2/HADH/SLC27A2/ECI1/ETFB/ECHS1 6 GO:0045089 positive regulation of innate immune response 7/436 131/18722 0.0337693026966243 0.211042764211508 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/XRCC5/XRCC6 7 GO:0032784 regulation of DNA-templated transcription, elongation 4/436 53/18722 0.03469947153805 0.215546956869805 EZH2/SUPT16H/ZNF326/HMGN1 4 GO:0051443 positive regulation of ubiquitin-protein transferase activity 3/436 31/18722 0.0348177864810758 0.215546956869805 UBE2C/UBE2S/RPS2 3 GO:1900027 regulation of ruffle assembly 3/436 31/18722 0.0348177864810758 0.215546956869805 HRAS/TACSTD2/RDX 3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/436 31/18722 0.0348177864810758 0.215546956869805 BRCA1/HMGB2/GPX1 3 GO:0019058 viral life cycle 13/436 317/18722 0.0353776538977873 0.215546956869805 CDK1/TOP2A/DEK/SIVA1/HACD3/PPIA/NUCKS1/HSPA8/LY6E/CD81/SRPK1/ILF3/DYNLT1 13 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 5/436 78/18722 0.035390607398456 0.215546956869805 CASP8AP2/ANP32B/BAX/HSPD1/CTSH 5 GO:0001682 tRNA 5'-leader removal 2/436 13/18722 0.0356208465593645 0.215546956869805 POP7/RPP30 2 GO:0001833 inner cell mass cell proliferation 2/436 13/18722 0.0356208465593645 0.215546956869805 CHEK1/BRCA2 2 GO:0009650 UV protection 2/436 13/18722 0.0356208465593645 0.215546956869805 FEN1/GPX1 2 GO:0016078 tRNA catabolic process 2/436 13/18722 0.0356208465593645 0.215546956869805 EXOSC9/EXOSC8 2 GO:0042538 hyperosmotic salinity response 2/436 13/18722 0.0356208465593645 0.215546956869805 XRCC5/XRCC6 2 GO:0043928 exonucleolytic catabolism of deadenylated mRNA 2/436 13/18722 0.0356208465593645 0.215546956869805 EXOSC9/EXOSC8 2 GO:0043970 histone H3-K9 acetylation 2/436 13/18722 0.0356208465593645 0.215546956869805 BRCA1/CHEK1 2 GO:0044794 positive regulation by host of viral process 2/436 13/18722 0.0356208465593645 0.215546956869805 NUCKS1/HSPA8 2 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/436 13/18722 0.0356208465593645 0.215546956869805 CALM2/GSTO1 2 GO:0071027 nuclear RNA surveillance 2/436 13/18722 0.0356208465593645 0.215546956869805 EXOSC9/EXOSC8 2 GO:0071028 nuclear mRNA surveillance 2/436 13/18722 0.0356208465593645 0.215546956869805 EXOSC9/EXOSC8 2 GO:0072710 response to hydroxyurea 2/436 13/18722 0.0356208465593645 0.215546956869805 RAD51/BLM 2 GO:0034660 ncRNA metabolic process 18/436 485/18722 0.0359165350405545 0.216953576979124 NOP56/PRKDC/POLR3K/EXOSC9/PA2G4/EXOSC8/RPS21/TSEN34/POP7/RPP30/LAGE3/RPS17/HNRNPA2B1/RPL35/HRAS/TPRKB/RPS7/RPL7A 18 GO:0015980 energy derivation by oxidation of organic compounds 13/436 318/18722 0.0361407132904166 0.217924055007767 CDK1/HMGB1/MSH2/DHTKD1/PPIF/FH/UQCC2/IDH2/CHCHD2/COX5A/COX8A/PTGES3/NDUFA4 13 GO:0009259 ribonucleotide metabolic process 15/436 385/18722 0.0368959005848053 0.221816076086982 DHTKD1/NUDT8/GMPS/HINT1/PAICS/PARP1/RAN/RNASEH2B/SLC25A1/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 15 GO:1904951 positive regulation of establishment of protein localization 13/436 319/18722 0.0369154705466822 0.221816076086982 CDK1/KIF20B/CENPJ/PPIA/RAN/ANP32B/SAE1/CD81/HRAS/MYH10/MPC2/WLS/CCT5 13 GO:0046822 regulation of nucleocytoplasmic transport 6/436 106/18722 0.0375770809025516 0.225396791217927 CDK1/BARD1/NUP62/RAN/ANP32B/KHDRBS1 6 GO:0042744 hydrogen peroxide catabolic process 3/436 32/18722 0.0377754862440977 0.226191436829842 PRDX2/PRDX4/GPX1 3 GO:1901654 response to ketone 9/436 194/18722 0.03834768935045 0.229217634427515 TYMS/PCNA/NASP/PARP1/CDK4/MTAP/HNRNPD/NME1/CCND1 9 GO:0072594 establishment of protein localization to organelle 16/436 422/18722 0.0392720687264763 0.234334726609635 CDK1/BRCA2/NUP62/KPNB1/RAN/NXT1/SAE1/TOMM40/HSP90AA1/HSPA8/CSE1L/BAX/CCT5/HSPD1/LMAN1/PHB2 16 GO:0071241 cellular response to inorganic substance 10/436 226/18722 0.0394916992775277 0.235236146217357 RAD51/BLM/CCNA2/MT2A/FUS/PARP1/CACYBP/JUN/PPIF/HNRNPD 10 GO:0034440 lipid oxidation 6/436 108/18722 0.0405833028199486 0.238013425069486 ACAT2/HADH/SLC27A2/ECI1/ETFB/ECHS1 6 GO:0140053 mitochondrial gene expression 6/436 108/18722 0.0405833028199486 0.238013425069486 TFAM/UQCC2/MRPS34/C1QBP/TUFM/MRPL57 6 GO:0006096 glycolytic process 5/436 81/18722 0.0406329640985491 0.238013425069486 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0051817 modulation of process of other organism involved in symbiotic interaction 5/436 81/18722 0.0406329640985491 0.238013425069486 JUN/NUCKS1/HSPA8/PSMC3/PHB2 5 GO:0061013 regulation of mRNA catabolic process 8/436 166/18722 0.0408429407277524 0.238013425069486 CARHSP1/FUS/EXOSC9/EXOSC8/SERBP1/HNRNPR/HNRNPD/YBX1 8 GO:0010259 multicellular organism aging 3/436 33/18722 0.0408572754118374 0.238013425069486 MSH2/MSH6/CTSV 3 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 3/436 33/18722 0.0408572754118374 0.238013425069486 CDC6/CKS1B/CCND1 3 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 2/436 14/18722 0.0409291520813164 0.238013425069486 TYMS/DUT 2 GO:0035563 positive regulation of chromatin binding 2/436 14/18722 0.0409291520813164 0.238013425069486 GMNN/CDT1 2 GO:0042921 glucocorticoid receptor signaling pathway 2/436 14/18722 0.0409291520813164 0.238013425069486 YWHAH/PTGES3 2 GO:0045472 response to ether 2/436 14/18722 0.0409291520813164 0.238013425069486 CDK4/HNRNPD 2 GO:0046655 folic acid metabolic process 2/436 14/18722 0.0409291520813164 0.238013425069486 DHFR/MTHFD2 2 GO:0048291 isotype switching to IgG isotypes 2/436 14/18722 0.0409291520813164 0.238013425069486 MSH2/HSPD1 2 GO:1900037 regulation of cellular response to hypoxia 2/436 14/18722 0.0409291520813164 0.238013425069486 ENO1/CHCHD2 2 GO:0031960 response to corticosteroid 8/436 167/18722 0.0420671224614481 0.244217084881943 TYMS/PCNA/HMGB1/PARP1/GSTP1/CTSV/CCND1/HSPD1 8 GO:0002312 B cell activation involved in immune response 5/436 82/18722 0.0424794214990165 0.245365143372265 UNG/MSH2/MSH6/RIF1/HSPD1 5 GO:0006757 ATP generation from ADP 5/436 82/18722 0.0424794214990165 0.245365143372265 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 5/436 82/18722 0.0424794214990165 0.245365143372265 BRCA1/HMGB2/CASP8AP2/BAX/GPX1 5 GO:0090305 nucleic acid phosphodiester bond hydrolysis 11/436 261/18722 0.04277114482322 0.2466349544344 FEN1/RNASEH2A/POLR3K/EXOSC9/EXOSC8/RPS21/TSEN34/POP7/RPP30/BAX/POLR2I 11 GO:0002833 positive regulation of response to biotic stimulus 8/436 168/18722 0.0433153890883275 0.249354194567201 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/XRCC5/XRCC6/HSPD1 8 GO:0032212 positive regulation of telomere maintenance via telomerase 3/436 34/18722 0.0440618820901258 0.25280320644017 AURKB/XRCC5/CCT5 3 GO:0051085 chaperone cofactor-dependent protein refolding 3/436 34/18722 0.0440618820901258 0.25280320644017 SDF2L1/HSPA8/PTGES3 3 GO:0031397 negative regulation of protein ubiquitination 5/436 83/18722 0.044375685193043 0.253754959828884 MAD2L1/FBXO5/PPIA/RPS3/RPS7 5 GO:0046785 microtubule polymerization 5/436 83/18722 0.044375685193043 0.253754959828884 FBXO5/STMN1/TPX2/CENPJ/RPS3 5 GO:0071902 positive regulation of protein serine/threonine kinase activity 9/436 200/18722 0.045055269816964 0.255338701589766 CDC6/EZH2/CKS1B/CALM2/DBF4/HRAS/CCND1/RPS3/ERP29 9 GO:0019693 ribose phosphate metabolic process 15/436 396/18722 0.0452537876175133 0.255338701589766 DHTKD1/NUDT8/GMPS/HINT1/PAICS/PARP1/RAN/RNASEH2B/SLC25A1/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 15 GO:0007292 female gamete generation 7/436 140/18722 0.0456790713586472 0.255338701589766 TOP2A/FBXO5/BRCA2/TTK/ASPM/RAD51C/CCNB2 7 GO:0043487 regulation of RNA stability 8/436 170/18722 0.045884734458438 0.255338701589766 CARHSP1/FUS/EXOSC9/EXOSC8/SERBP1/HNRNPR/HNRNPD/YBX1 8 GO:0018208 peptidyl-proline modification 4/436 58/18722 0.0459841726675648 0.255338701589766 PPIC/PPIA/PPIF/PRDX4 4 GO:0032481 positive regulation of type I interferon production 4/436 58/18722 0.0459841726675648 0.255338701589766 HMGB2/HMGB1/HSP90AA1/HSPD1 4 GO:0001325 formation of extrachromosomal circular DNA 2/436 15/18722 0.0465131706480919 0.255338701589766 BLM/XRCC5 2 GO:0006089 lactate metabolic process 2/436 15/18722 0.0465131706480919 0.255338701589766 PNKD/LDHA 2 GO:0009163 nucleoside biosynthetic process 2/436 15/18722 0.0465131706480919 0.255338701589766 DTYMK/MTAP 2 GO:0031958 corticosteroid receptor signaling pathway 2/436 15/18722 0.0465131706480919 0.255338701589766 YWHAH/PTGES3 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/436 15/18722 0.0465131706480919 0.255338701589766 BRCA1/PHB2 2 GO:0034404 nucleobase-containing small molecule biosynthetic process 2/436 15/18722 0.0465131706480919 0.255338701589766 DTYMK/MTAP 2 GO:0044793 negative regulation by host of viral process 2/436 15/18722 0.0465131706480919 0.255338701589766 NUCKS1/PSMC3 2 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 2/436 15/18722 0.0465131706480919 0.255338701589766 CDT1/ANAPC11 2 GO:0048308 organelle inheritance 2/436 15/18722 0.0465131706480919 0.255338701589766 CDK1/VRK1 2 GO:0048313 Golgi inheritance 2/436 15/18722 0.0465131706480919 0.255338701589766 CDK1/VRK1 2 GO:0050746 regulation of lipoprotein metabolic process 2/436 15/18722 0.0465131706480919 0.255338701589766 SVIP/DBI 2 GO:0051284 positive regulation of sequestering of calcium ion 2/436 15/18722 0.0465131706480919 0.255338701589766 CALM2/GSTO1 2 GO:0051290 protein heterotetramerization 2/436 15/18722 0.0465131706480919 0.255338701589766 RRM2/RRM1 2 GO:0070131 positive regulation of mitochondrial translation 2/436 15/18722 0.0465131706480919 0.255338701589766 UQCC2/C1QBP 2 GO:0071025 RNA surveillance 2/436 15/18722 0.0465131706480919 0.255338701589766 EXOSC9/EXOSC8 2 GO:0071474 cellular hyperosmotic response 2/436 15/18722 0.0465131706480919 0.255338701589766 XRCC5/XRCC6 2 GO:0090656 t-circle formation 2/436 15/18722 0.0465131706480919 0.255338701589766 BLM/XRCC5 2 GO:0090737 telomere maintenance via telomere trimming 2/436 15/18722 0.0465131706480919 0.255338701589766 BLM/XRCC5 2 GO:1901970 positive regulation of mitotic sister chromatid separation 2/436 15/18722 0.0465131706480919 0.255338701589766 CDT1/ANAPC11 2 GO:0052548 regulation of endopeptidase activity 16/436 432/18722 0.0467917886242564 0.256457870239335 HMGB1/BIRC5/DHCR24/CASP8AP2/ANP32B/BCL2L12/MGMT/RPS3/BAX/PEBP1/PERP/SPINT2/APLP2/HSPD1/GPX1/CTSH 16 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 3/436 35/18722 0.0473878854529344 0.258851770152078 BRCA1/PARP1/PHB2 3 GO:0045454 cell redox homeostasis 3/436 35/18722 0.0473878854529344 0.258851770152078 PRDX2/PRDX4/GPX1 3 GO:0032388 positive regulation of intracellular transport 9/436 202/18722 0.0474549004446683 0.258851770152078 CDK1/KIF20B/RAN/ANP32B/SAE1/CD81/HRAS/RDX/KHDRBS1 9 GO:0009142 nucleoside triphosphate biosynthetic process 5/436 85/18722 0.0483181566774505 0.262725191062334 TYMS/DTYMK/PARP1/ENO1/NME1 5 GO:0045069 regulation of viral genome replication 5/436 85/18722 0.0483181566774505 0.262725191062334 TOP2A/HACD3/PPIA/SRPK1/ILF3 5 GO:1901136 carbohydrate derivative catabolic process 8/436 172/18722 0.048552031500035 0.263579145690855 DUT/UNG/NUDT8/HINT1/DCTPP1/NUDT1/NUDT15/DNPH1 8 GO:0006913 nucleocytoplasmic transport 12/436 301/18722 0.0502257359623322 0.271556888971413 CDK1/BARD1/NUP62/KPNB1/RAN/ANP32B/NXT1/CSE1L/HNRNPA2B1/SRSF3/KHDRBS1/PHB2 12 GO:0051169 nuclear transport 12/436 301/18722 0.0502257359623322 0.271556888971413 CDK1/BARD1/NUP62/KPNB1/RAN/ANP32B/NXT1/CSE1L/HNRNPA2B1/SRSF3/KHDRBS1/PHB2 12 GO:0000209 protein polyubiquitination 10/436 236/18722 0.0503149127766489 0.271556888971413 DTL/UBE2T/BRCA1/UBE2C/BARD1/UBE2S/PPIA/RUSC1/ANAPC11/KLHL42 10 GO:0009150 purine ribonucleotide metabolic process 14/436 368/18722 0.0503381467169392 0.271556888971413 DHTKD1/NUDT8/GMPS/HINT1/PAICS/PARP1/RAN/SLC25A1/ENO1/NME1/MPC2/TPI1/LDHA/PGAM1 14 GO:0045738 negative regulation of DNA repair 3/436 36/18722 0.0508337265715611 0.273435470312941 RMI2/RPS3/RIF1 3 GO:0006081 cellular aldehyde metabolic process 4/436 60/18722 0.0510051591373601 0.273435470312941 AKR7A2/PNKD/IDH2/TPI1 4 GO:0031638 zymogen activation 4/436 60/18722 0.0510051591373601 0.273435470312941 DHCR24/ENO1/PERP/CTSH 4 GO:0051851 modulation by host of symbiont process 4/436 60/18722 0.0510051591373601 0.273435470312941 JUN/NUCKS1/HSPA8/PSMC3 4 GO:0006206 pyrimidine nucleobase metabolic process 2/436 16/18722 0.0523572457042602 0.274256045818804 TYMS/RRM1 2 GO:0006544 glycine metabolic process 2/436 16/18722 0.0523572457042602 0.274256045818804 DHFR/GCSH 2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2/436 16/18722 0.0523572457042602 0.274256045818804 BRCA2/FOXM1 2 GO:0010225 response to UV-C 2/436 16/18722 0.0523572457042602 0.274256045818804 BRCA2/HMGN1 2 GO:0014819 regulation of skeletal muscle contraction 2/436 16/18722 0.0523572457042602 0.274256045818804 C12orf57/GSTO1 2 GO:0035067 negative regulation of histone acetylation 2/436 16/18722 0.0523572457042602 0.274256045818804 BRCA1/SET 2 GO:0043923 positive regulation by host of viral transcription 2/436 16/18722 0.0523572457042602 0.274256045818804 JUN/NUCKS1 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/436 16/18722 0.0523572457042602 0.274256045818804 CD81/RPS3 2 GO:0061684 chaperone-mediated autophagy 2/436 16/18722 0.0523572457042602 0.274256045818804 HSP90AA1/HSPA8 2 GO:0070200 establishment of protein localization to telomere 2/436 16/18722 0.0523572457042602 0.274256045818804 BRCA2/CCT5 2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 2/436 16/18722 0.0523572457042602 0.274256045818804 LAGE3/TPRKB 2 GO:0071732 cellular response to nitric oxide 2/436 16/18722 0.0523572457042602 0.274256045818804 CCNA2/HNRNPD 2 GO:0099116 tRNA 5'-end processing 2/436 16/18722 0.0523572457042602 0.274256045818804 POP7/RPP30 2 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 2/436 16/18722 0.0523572457042602 0.274256045818804 CDT1/ANAPC11 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/436 16/18722 0.0523572457042602 0.274256045818804 PRKDC/RIF1 2 GO:1903578 regulation of ATP metabolic process 5/436 87/18722 0.0524611415320291 0.274381366762792 PARP1/PPIF/UQCC2/ENO1/PGAM1 5 GO:0022900 electron transport chain 8/436 175/18722 0.0527387026591597 0.275413224997834 CDK1/AKR7A2/CHCHD2/ETFB/CYB5A/COX5A/COX8A/NDUFA4 8 GO:0007265 Ras protein signal transduction 13/436 337/18722 0.0529488885391716 0.275671679177387 STMN1/CCNA2/FOXM1/DHCR24/HACD3/NUP62/KPNB1/CTNNAL1/CDKN2A/JUN/HRAS/DYNLT1/RDX 13 GO:0032386 regulation of intracellular transport 13/436 337/18722 0.0529488885391716 0.275671679177387 CDK1/BARD1/KIF20B/NUP62/RAN/ANP32B/SAE1/SVIP/CD81/HRAS/RDX/KHDRBS1/LMAN1 13 GO:0061351 neural precursor cell proliferation 7/436 145/18722 0.0533285353580785 0.277227583050859 RRM1/MELK/SHCBP1/ASPM/NAP1L1/PSMG1/SPINT2 7 GO:0043966 histone H3 acetylation 4/436 61/18722 0.0536237371860063 0.278340457314959 BRCA1/CHEK1/BRCA2/POLE3 4 GO:0018107 peptidyl-threonine phosphorylation 6/436 116/18722 0.0541013575008728 0.279399061415976 CDK1/CHEK1/VRK1/TTK/CALM2/PRKDC 6 GO:0031123 RNA 3'-end processing 6/436 116/18722 0.0541013575008728 0.279399061415976 BARD1/SLBP/POLR3K/EXOSC9/EXOSC8/RPS21 6 GO:0006862 nucleotide transport 3/436 37/18722 0.0543977187484325 0.279399061415976 SLC29A1/SLC25A5/SLC25A6 3 GO:0043403 skeletal muscle tissue regeneration 3/436 37/18722 0.0543977187484325 0.279399061415976 EZH2/CD81/GPX1 3 GO:0043687 post-translational protein modification 3/436 37/18722 0.0543977187484325 0.279399061415976 ESCO2/DSCC1/FN3KRP 3 GO:0051294 establishment of spindle orientation 3/436 37/18722 0.0543977187484325 0.279399061415976 MAD2L1/NDC80/DYNLT1 3 GO:0072529 pyrimidine-containing compound catabolic process 3/436 37/18722 0.0543977187484325 0.279399061415976 DUT/UNG/DCTPP1 3 GO:0009144 purine nucleoside triphosphate metabolic process 5/436 88/18722 0.0546079404207747 0.280059556926275 PARP1/RAN/NUDT15/ENO1/NME1 5 GO:0048545 response to steroid hormone 13/436 339/18722 0.0549843465496831 0.281569094047706 TYMS/PCNA/BRCA1/HMGB2/HMGB1/YWHAH/PARP1/GSTP1/CTSV/CCND1/PTGES3/HSPD1/PHB2 13 GO:0032886 regulation of microtubule-based process 10/436 240/18722 0.0551497247293752 0.281995090233214 BRCA1/STMN1/SKA3/TPX2/NUP62/CENPJ/CKAP2/SKA2/RPS3/KLHL42 10 GO:0022411 cellular component disassembly 16/436 443/18722 0.0561827484280072 0.286849717048352 CDK1/TOP2A/STMN1/VRK1/TPX2/SUPT16H/CKAP2/SLC25A5/SET/CTSV/HSPA8/HMGA1/BAX/VDAC1/RDX/PHB2 16 GO:0046824 positive regulation of nucleocytoplasmic transport 4/436 62/18722 0.0563140036408246 0.287092639660727 CDK1/RAN/ANP32B/KHDRBS1 4 GO:1903313 positive regulation of mRNA metabolic process 6/436 118/18722 0.0578594655451742 0.292743425648311 EXOSC9/EXOSC8/HNRNPR/HNRNPD/HSPA8/RBMX 6 GO:0051384 response to glucocorticoid 7/436 148/18722 0.0582812880258556 0.292743425648311 TYMS/PCNA/HMGB1/GSTP1/CTSV/CCND1/HSPD1 7 GO:0070507 regulation of microtubule cytoskeleton organization 7/436 148/18722 0.0582812880258556 0.292743425648311 STMN1/SKA3/TPX2/NUP62/CKAP2/SKA2/RPS3 7 GO:0008340 determination of adult lifespan 2/436 17/18722 0.0584462974552879 0.292743425648311 MSH2/MSH6 2 GO:0009151 purine deoxyribonucleotide metabolic process 2/436 17/18722 0.0584462974552879 0.292743425648311 NUDT15/DNPH1 2 GO:0010224 response to UV-B 2/436 17/18722 0.0584462974552879 0.292743425648311 MSH2/HMGN1 2 GO:0015867 ATP transport 2/436 17/18722 0.0584462974552879 0.292743425648311 SLC25A5/SLC25A6 2 GO:0042772 DNA damage response, signal transduction resulting in transcription 2/436 17/18722 0.0584462974552879 0.292743425648311 BRCA2/FOXM1 2 GO:0045815 positive regulation of gene expression, epigenetic 2/436 17/18722 0.0584462974552879 0.292743425648311 CDCA4/CHEK1 2 GO:0090399 replicative senescence 2/436 17/18722 0.0584462974552879 0.292743425648311 CHEK1/CDKN2A 2 GO:0097067 cellular response to thyroid hormone stimulus 2/436 17/18722 0.0584462974552879 0.292743425648311 RDX/CTSH 2 GO:1904355 positive regulation of telomere capping 2/436 17/18722 0.0584462974552879 0.292743425648311 AURKB/HNRNPD 2 GO:0006399 tRNA metabolic process 8/436 179/18722 0.0586718552888154 0.29301766447733 POLR3K/EXOSC9/EXOSC8/TSEN34/POP7/RPP30/LAGE3/TPRKB 8 GO:0010950 positive regulation of endopeptidase activity 8/436 179/18722 0.0586718552888154 0.29301766447733 HMGB1/CASP8AP2/ANP32B/RPS3/BAX/PERP/HSPD1/CTSH 8 GO:0046031 ADP metabolic process 5/436 90/18722 0.0590521344211601 0.293751348664678 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0046902 regulation of mitochondrial membrane permeability 4/436 63/18722 0.059075613692401 0.293751348664678 SLC25A5/PPIF/BAX/DYNLT1 4 GO:1904589 regulation of protein import 4/436 63/18722 0.059075613692401 0.293751348664678 CDK1/NUP62/RAN/HSPA8 4 GO:1903829 positive regulation of cellular protein localization 11/436 276/18722 0.0592235981213246 0.294061020483741 CDK1/CDT1/NDC80/NUP62/PARP1/RAN/SAE1/CD81/HRAS/CCT5/RDX 11 GO:0043523 regulation of neuron apoptotic process 9/436 212/18722 0.0607192392014311 0.301051603612876 MYBL2/MSH2/PARP1/JUN/NAE1/SET/HRAS/BAX/HSPD1 9 GO:0017148 negative regulation of translation 10/436 245/18722 0.0616113098863719 0.303872574711078 TYMS/DHFR/EXOSC9/EXOSC8/HNRNPR/EIF4EBP1/HNRNPD/RPS3/ILF3/YBX1 10 GO:0072655 establishment of protein localization to mitochondrion 6/436 120/18722 0.0617702561093839 0.303872574711078 SAE1/TOMM40/HSP90AA1/BAX/HSPD1/LMAN1 6 GO:0002347 response to tumor cell 3/436 39/18722 0.0618728293269967 0.303872574711078 HMGB1/PRDX2/HSPD1 3 GO:0016233 telomere capping 3/436 39/18722 0.0618728293269967 0.303872574711078 AURKB/PRKDC/HNRNPD 3 GO:0032728 positive regulation of interferon-beta production 3/436 39/18722 0.0618728293269967 0.303872574711078 HMGB2/HMGB1/HSP90AA1 3 GO:0051084 'de novo' posttranslational protein folding 3/436 39/18722 0.0618728293269967 0.303872574711078 SDF2L1/HSPA8/PTGES3 3 GO:0070542 response to fatty acid 4/436 64/18722 0.0619081695491237 0.303872574711078 ID3/CDK4/XRCC5/NME1 4 GO:0051402 neuron apoptotic process 10/436 246/18722 0.0629600396049565 0.308594136978008 MYBL2/MSH2/PARP1/JUN/NAE1/SET/HRAS/BAX/HSPD1/GPX1 10 GO:0050678 regulation of epithelial cell proliferation 14/436 381/18722 0.0633291695478758 0.309960600169418 HMGB2/HMGB1/BRCA2/ID1/PRKDC/HMGN1/MARVELD3/NME1/HRAS/CCND1/SUZ12/BAX/PHB2/GPX1 14 GO:0071456 cellular response to hypoxia 7/436 151/18722 0.0635091038686666 0.310398483437885 CCNA2/SLC29A1/EIF4EBP1/ENO1/CHCHD2/HILPDA/PHB2 7 GO:0046112 nucleobase biosynthetic process 2/436 18/18722 0.0647658045965319 0.313193384587854 GMPS/PAICS 2 GO:0048268 clathrin coat assembly 2/436 18/18722 0.0647658045965319 0.313193384587854 NSG1/AP2S1 2 GO:0051447 negative regulation of meiotic cell cycle 2/436 18/18722 0.0647658045965319 0.313193384587854 FBXO5/TTK 2 GO:0060749 mammary gland alveolus development 2/436 18/18722 0.0647658045965319 0.313193384587854 CCND1/PHB2 2 GO:0061377 mammary gland lobule development 2/436 18/18722 0.0647658045965319 0.313193384587854 CCND1/PHB2 2 GO:1902170 cellular response to reactive nitrogen species 2/436 18/18722 0.0647658045965319 0.313193384587854 CCNA2/HNRNPD 2 GO:1905820 positive regulation of chromosome separation 2/436 18/18722 0.0647658045965319 0.313193384587854 CDT1/ANAPC11 2 GO:0048524 positive regulation of viral process 4/436 65/18722 0.0648112221094073 0.313193384587854 TOP2A/HACD3/PPIA/SRPK1 4 GO:0006730 one-carbon metabolic process 3/436 40/18722 0.0657800219292176 0.315211250334002 TYMS/DHFR/MTHFD2 3 GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/436 40/18722 0.0657800219292176 0.315211250334002 STMN1/TPX2/CKAP2 3 GO:0044275 cellular carbohydrate catabolic process 3/436 40/18722 0.0657800219292176 0.315211250334002 HMGB1/TPI1/PGAM1 3 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 3/436 40/18722 0.0657800219292176 0.315211250334002 CALM2/BAX/GSTO1 3 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 3/436 40/18722 0.0657800219292176 0.315211250334002 SLC25A5/PPIF/BAX 3 GO:2000142 regulation of DNA-templated transcription, initiation 3/436 40/18722 0.0657800219292176 0.315211250334002 HMGB1/CDK4/JUN 3 GO:0033273 response to vitamin 5/436 93/18722 0.0660940467897063 0.316274302002067 TYMS/SRSF2/GSTP1/MGMT/CCND1 5 GO:0002449 lymphocyte mediated immunity 13/436 350/18722 0.0671307387187587 0.32078769435106 UNG/HMGB1/TUBB/MSH2/MSH6/TUBB4B/EMP2/CADM1/CD81/RIF1/C1QBP/HSPD1/CTSH 13 GO:0043967 histone H4 acetylation 4/436 67/18722 0.0708267744976173 0.333746834579549 BRCA1/BRCA2/HAT1/YEATS4 4 GO:0006606 protein import into nucleus 7/436 155/18722 0.0709096071395159 0.333746834579549 CDK1/NUP62/KPNB1/RAN/NXT1/CSE1L/PHB2 7 GO:0032479 regulation of type I interferon production 5/436 95/18722 0.0710377733603508 0.333746834579549 HMGB2/HMGB1/POLA1/HSP90AA1/HSPD1 5 GO:0032606 type I interferon production 5/436 95/18722 0.0710377733603508 0.333746834579549 HMGB2/HMGB1/POLA1/HSP90AA1/HSPD1 5 GO:0042773 ATP synthesis coupled electron transport 5/436 95/18722 0.0710377733603508 0.333746834579549 CDK1/CHCHD2/COX5A/COX8A/NDUFA4 5 GO:0042775 mitochondrial ATP synthesis coupled electron transport 5/436 95/18722 0.0710377733603508 0.333746834579549 CDK1/CHCHD2/COX5A/COX8A/NDUFA4 5 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5/436 95/18722 0.0710377733603508 0.333746834579549 MAD2L1/FBXO5/PPIA/RPS3/RPS7 5 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 2/436 19/18722 0.0713017865773272 0.333746834579549 EXOSC9/EXOSC8 2 GO:0006071 glycerol metabolic process 2/436 19/18722 0.0713017865773272 0.333746834579549 PGP/TPI1 2 GO:0006144 purine nucleobase metabolic process 2/436 19/18722 0.0713017865773272 0.333746834579549 GMPS/PAICS 2 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 2/436 19/18722 0.0713017865773272 0.333746834579549 GMPS/PAICS 2 GO:0044827 modulation by host of viral genome replication 2/436 19/18722 0.0713017865773272 0.333746834579549 NUCKS1/HSPA8 2 GO:0070734 histone H3-K27 methylation 2/436 19/18722 0.0713017865773272 0.333746834579549 EZH2/SUZ12 2 GO:1901659 glycosyl compound biosynthetic process 2/436 19/18722 0.0713017865773272 0.333746834579549 DTYMK/MTAP 2 GO:2000042 negative regulation of double-strand break repair via homologous recombination 2/436 19/18722 0.0713017865773272 0.333746834579549 RMI2/RIF1 2 GO:0018210 peptidyl-threonine modification 6/436 125/18722 0.0722158426481661 0.337105518538582 CDK1/CHEK1/VRK1/TTK/CALM2/PRKDC 6 GO:0070585 protein localization to mitochondrion 6/436 125/18722 0.0722158426481661 0.337105518538582 SAE1/TOMM40/HSP90AA1/BAX/HSPD1/LMAN1 6 GO:0000413 protein peptidyl-prolyl isomerization 3/436 42/18722 0.0739231713925549 0.343672630146146 PPIC/PPIA/PPIF 3 GO:0071312 cellular response to alkaloid 3/436 42/18722 0.0739231713925549 0.343672630146146 RAD51/BLM/CCNA2 3 GO:0090317 negative regulation of intracellular protein transport 3/436 42/18722 0.0739231713925549 0.343672630146146 BARD1/SVIP/LMAN1 3 GO:0052547 regulation of peptidase activity 16/436 461/18722 0.0742270786193414 0.344618547690068 HMGB1/BIRC5/DHCR24/CASP8AP2/ANP32B/BCL2L12/MGMT/RPS3/BAX/PEBP1/PERP/SPINT2/APLP2/HSPD1/GPX1/CTSH 16 GO:2001235 positive regulation of apoptotic signaling pathway 6/436 126/18722 0.0744193692807316 0.345044400002959 RPS3/BAX/RPS7/ITM2C/PDIA3/CTSH 6 GO:1902600 proton transmembrane transport 7/436 157/18722 0.0747945083116866 0.345849000023446 SLC25A5/PPIF/CYB5A/COX5A/COX8A/NDUFA4/PHB2 7 GO:2000377 regulation of reactive oxygen species metabolic process 7/436 157/18722 0.0747945083116866 0.345849000023446 DHFR/BRCA1/FOXM1/PRDX2/GSTP1/VDAC1/HSPD1 7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 5/436 97/18722 0.0761792170258379 0.351777784139502 BRCA1/HMGB2/PRDX2/GSTP1/GPX1 5 GO:0008033 tRNA processing 6/436 127/18722 0.0766608925469567 0.353051707823635 POLR3K/TSEN34/POP7/RPP30/LAGE3/TPRKB 6 GO:0051224 negative regulation of protein transport 6/436 127/18722 0.0766608925469567 0.353051707823635 BARD1/HADH/SVIP/IDH2/LMAN1/ERP29 6 GO:0001832 blastocyst growth 2/436 20/18722 0.0780407863852481 0.354225504298917 CHEK1/BRCA2 2 GO:0002834 regulation of response to tumor cell 2/436 20/18722 0.0780407863852481 0.354225504298917 HMGB1/HSPD1 2 GO:0002837 regulation of immune response to tumor cell 2/436 20/18722 0.0780407863852481 0.354225504298917 HMGB1/HSPD1 2 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 2/436 20/18722 0.0780407863852481 0.354225504298917 TYMS/DUT 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/436 20/18722 0.0780407863852481 0.354225504298917 CALM2/GSTO1 2 GO:0071243 cellular response to arsenic-containing substance 2/436 20/18722 0.0780407863852481 0.354225504298917 PPIF/GSTO1 2 GO:0071731 response to nitric oxide 2/436 20/18722 0.0780407863852481 0.354225504298917 CCNA2/HNRNPD 2 GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/436 20/18722 0.0780407863852481 0.354225504298917 PPIF/GPX1 2 GO:1901679 nucleotide transmembrane transport 2/436 20/18722 0.0780407863852481 0.354225504298917 SLC25A5/SLC25A6 2 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/436 20/18722 0.0780407863852481 0.354225504298917 PPIA/GPX1 2 GO:0035794 positive regulation of mitochondrial membrane permeability 3/436 43/18722 0.0781546799050655 0.354225504298917 SLC25A5/PPIF/BAX 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/436 43/18722 0.0781546799050655 0.354225504298917 MSH2/BRCA2/TMEM109 3 GO:0051170 import into nucleus 7/436 159/18722 0.0788024218643741 0.355846778120271 CDK1/NUP62/KPNB1/RAN/NXT1/CSE1L/PHB2 7 GO:0070301 cellular response to hydrogen peroxide 5/436 98/18722 0.0788235358121264 0.355846778120271 PCNA/CDK1/EZH2/PPIF/RPS3 5 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 5/436 98/18722 0.0788235358121264 0.355846778120271 HELLS/PPIA/PPIF/ENO1/GPX1 5 GO:0090316 positive regulation of intracellular protein transport 7/436 160/18722 0.0808524342040615 0.364526546326065 CDK1/KIF20B/RAN/ANP32B/SAE1/CD81/HRAS 7 GO:0009126 purine nucleoside monophosphate metabolic process 3/436 44/18722 0.0824897274617043 0.370933492688214 GMPS/PAICS/DNPH1 3 GO:0097178 ruffle assembly 3/436 44/18722 0.0824897274617043 0.370933492688214 HRAS/TACSTD2/RDX 3 GO:0036294 cellular response to decreased oxygen levels 7/436 161/18722 0.0829330918669341 0.372439055229648 CCNA2/SLC29A1/EIF4EBP1/ENO1/CHCHD2/HILPDA/PHB2 7 GO:0006626 protein targeting to mitochondrion 5/436 100/18722 0.0842580638615794 0.376169765821136 SAE1/TOMM40/HSP90AA1/HSPD1/LMAN1 5 GO:0044728 DNA methylation or demethylation 5/436 100/18722 0.0842580638615794 0.376169765821136 HELLS/BRCA1/EZH2/PARP1/MGMT 5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 2/436 21/18722 0.0849698538360189 0.376169765821136 COX5A/COX8A 2 GO:0007289 spermatid nucleus differentiation 2/436 21/18722 0.0849698538360189 0.376169765821136 HMGB2/SRPK1 2 GO:0009127 purine nucleoside monophosphate biosynthetic process 2/436 21/18722 0.0849698538360189 0.376169765821136 GMPS/PAICS 2 GO:0016075 rRNA catabolic process 2/436 21/18722 0.0849698538360189 0.376169765821136 EXOSC9/EXOSC8 2 GO:0032516 positive regulation of phosphoprotein phosphatase activity 2/436 21/18722 0.0849698538360189 0.376169765821136 CALM2/SLC39A10 2 GO:0033962 P-body assembly 2/436 21/18722 0.0849698538360189 0.376169765821136 LSM4/LSM3 2 GO:0034471 ncRNA 5'-end processing 2/436 21/18722 0.0849698538360189 0.376169765821136 POP7/RPP30 2 GO:0071605 monocyte chemotactic protein-1 production 2/436 21/18722 0.0849698538360189 0.376169765821136 HMGB1/GSTP1 2 GO:0071637 regulation of monocyte chemotactic protein-1 production 2/436 21/18722 0.0849698538360189 0.376169765821136 HMGB1/GSTP1 2 GO:0046683 response to organophosphorus 6/436 131/18722 0.08600494865159 0.379772173518153 TYMS/RFC3/JUN/NME1/LDHA/HSPD1 6 GO:1904950 negative regulation of establishment of protein localization 6/436 131/18722 0.08600494865159 0.379772173518153 BARD1/HADH/SVIP/IDH2/LMAN1/ERP29 6 GO:0010824 regulation of centrosome duplication 3/436 45/18722 0.0869259236965394 0.381479783230854 BRCA1/NUP62/CENPJ 3 GO:0035307 positive regulation of protein dephosphorylation 3/436 45/18722 0.0869259236965394 0.381479783230854 CALM2/PPIA/SLC39A10 3 GO:0048538 thymus development 3/436 45/18722 0.0869259236965394 0.381479783230854 PRKDC/CCNB2/PRDX2 3 GO:0071364 cellular response to epidermal growth factor stimulus 3/436 45/18722 0.0869259236965394 0.381479783230854 MCM7/ID1/GSTP1 3 GO:0051258 protein polymerization 11/436 296/18722 0.0869675797247745 0.381479783230854 DIAPH3/FBXO5/STMN1/UBE2C/TPX2/UBE2S/CENPJ/HSP90AA1/ARPC5L/RPS3/RDX 11 GO:0030330 DNA damage response, signal transduction by p53 class mediator 4/436 72/18722 0.0870587788603202 0.381479783230854 BRCA2/FOXM1/GTSE1/EEF1E1 4 GO:0001701 in utero embryonic development 13/436 367/18722 0.0891646531585062 0.390209087993412 RRM2/ASF1B/CHEK1/NASP/MSH2/BRCA2/CCNB2/RNASEH2B/COPS3/LY6E/YBX1/SLC39A1/SPINT2 13 GO:0050792 regulation of viral process 7/436 164/18722 0.089358335556041 0.390558534130926 TOP2A/HACD3/PPIA/LY6E/SRPK1/ILF3/DYNLT1 7 GO:0031647 regulation of protein stability 11/436 298/18722 0.0901177731585477 0.393376691739157 PRKDC/HSP90AA1/ATP1B3/HSPA8/CD81/RPS7/CCT5/PTGES3/HSPD1/PHB2/CTSH 11 GO:0010952 positive regulation of peptidase activity 8/436 197/18722 0.0904287539356987 0.394060095337907 HMGB1/CASP8AP2/ANP32B/RPS3/BAX/PERP/HSPD1/CTSH 8 GO:0002637 regulation of immunoglobulin production 4/436 73/18722 0.0905040382180911 0.394060095337907 MSH2/PRKDC/RIF1/PHB2 4 GO:0006997 nucleus organization 6/436 133/18722 0.0909019539423858 0.39523874167066 CDK1/HMGB2/CHEK1/VRK1/SERBP1/SRPK1 6 GO:0007019 microtubule depolymerization 3/436 46/18722 0.0914608240837521 0.39523874167066 STMN1/TPX2/CKAP2 3 GO:0043462 regulation of ATPase activity 3/436 46/18722 0.0914608240837521 0.39523874167066 DNAJC9/PPIF/ATP1B3 3 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/436 22/18722 0.0920765293549426 0.39523874167066 CALM2/GSTO1 2 GO:0019400 alditol metabolic process 2/436 22/18722 0.0920765293549426 0.39523874167066 PGP/TPI1 2 GO:0032727 positive regulation of interferon-alpha production 2/436 22/18722 0.0920765293549426 0.39523874167066 HMGB1/HSPD1 2 GO:0035561 regulation of chromatin binding 2/436 22/18722 0.0920765293549426 0.39523874167066 GMNN/CDT1 2 GO:0036120 cellular response to platelet-derived growth factor stimulus 2/436 22/18722 0.0920765293549426 0.39523874167066 CCNA2/RDX 2 GO:0043486 histone exchange 2/436 22/18722 0.0920765293549426 0.39523874167066 CENPW/NASP 2 GO:0046628 positive regulation of insulin receptor signaling pathway 2/436 22/18722 0.0920765293549426 0.39523874167066 NUCKS1/SNX5 2 GO:0048026 positive regulation of mRNA splicing, via spliceosome 2/436 22/18722 0.0920765293549426 0.39523874167066 HSPA8/RBMX 2 GO:0042113 B cell activation 12/436 334/18722 0.0921570951141148 0.39523874167066 UNG/MSH2/EZH2/MSH6/PRKDC/SLC25A5/CD81/BAX/RIF1/SLC39A10/HSPD1/PHB2 12 GO:0009135 purine nucleoside diphosphate metabolic process 5/436 103/18722 0.0927699831665249 0.396875077611405 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0009179 purine ribonucleoside diphosphate metabolic process 5/436 103/18722 0.0927699831665249 0.396875077611405 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0032147 activation of protein kinase activity 6/436 134/18722 0.0934061534144305 0.399099019134385 CLSPN/HMGB1/TPX2/PPIA/EMP2/PHB2 6 GO:0002437 inflammatory response to antigenic stimulus 4/436 74/18722 0.0940137224980582 0.400696996137687 HMGB2/HMGB1/CD81/GPX1 4 GO:0010822 positive regulation of mitochondrion organization 4/436 74/18722 0.0940137224980582 0.400696996137687 SLC25A5/PPIF/BAX/VDAC1 4 GO:0007595 lactation 3/436 47/18722 0.0960919362514594 0.408539570357816 SLC29A1/NME1/CCND1 3 GO:1903170 negative regulation of calcium ion transmembrane transport 3/436 47/18722 0.0960919362514594 0.408539570357816 CALM2/VDAC1/GSTO1 3 GO:0072522 purine-containing compound biosynthetic process 8/436 200/18722 0.0965292595961398 0.409890952567272 GMPS/PAICS/PARP1/MTAP/SLC25A1/ENO1/NME1/MPC2 8 GO:0051222 positive regulation of protein transport 11/436 303/18722 0.0982939487916214 0.416868403342464 CDK1/KIF20B/PPIA/RAN/ANP32B/SAE1/CD81/HRAS/MYH10/MPC2/WLS 11 GO:0045727 positive regulation of translation 6/436 136/18722 0.0985250117513976 0.417332488048204 PRKDC/CDK4/HNRNPD/UQCC2/C1QBP/KHDRBS1 6 GO:0000966 RNA 5'-end processing 2/436 23/18722 0.0993488282361 0.417727732448602 POP7/RPP30 2 GO:0002082 regulation of oxidative phosphorylation 2/436 23/18722 0.0993488282361 0.417727732448602 PPIF/UQCC2 2 GO:0019430 removal of superoxide radicals 2/436 23/18722 0.0993488282361 0.417727732448602 DHFR/PRDX2 2 GO:0036119 response to platelet-derived growth factor 2/436 23/18722 0.0993488282361 0.417727732448602 CCNA2/RDX 2 GO:1902410 mitotic cytokinetic process 2/436 23/18722 0.0993488282361 0.417727732448602 KIF20B/NUP62 2 GO:2001169 regulation of ATP biosynthetic process 2/436 23/18722 0.0993488282361 0.417727732448602 PARP1/ENO1 2 GO:0009152 purine ribonucleotide biosynthetic process 7/436 169/18722 0.100672994792732 0.421318132544734 GMPS/PAICS/PARP1/SLC25A1/ENO1/NME1/MPC2 7 GO:0061647 histone H3-K9 modification 3/436 48/18722 0.100816725974709 0.421318132544734 BRCA1/CHEK1/RIF1 3 GO:0090199 regulation of release of cytochrome c from mitochondria 3/436 48/18722 0.100816725974709 0.421318132544734 PPIF/BAX/GPX1 3 GO:1905710 positive regulation of membrane permeability 3/436 48/18722 0.100816725974709 0.421318132544734 SLC25A5/PPIF/BAX 3 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 3/436 48/18722 0.100816725974709 0.421318132544734 PBK/SVIP/RPS7 3 GO:0014823 response to activity 4/436 76/18722 0.101222855900528 0.42250075254831 CDK1/HADH/PRKDC/HSPD1 4 GO:0001824 blastocyst development 5/436 106/18722 0.101705518618662 0.422971678037126 RRM2/ASF1B/CHEK1/NASP/BRCA2 5 GO:0009185 ribonucleoside diphosphate metabolic process 5/436 106/18722 0.101705518618662 0.422971678037126 DHTKD1/ENO1/TPI1/LDHA/PGAM1 5 GO:0035821 modulation of process of other organism 5/436 106/18722 0.101705518618662 0.422971678037126 JUN/NUCKS1/HSPA8/PSMC3/PHB2 5 GO:0044282 small molecule catabolic process 13/436 376/18722 0.102467078395691 0.425622937016483 ACAT2/NUDT8/IMPA2/HADH/NUDT1/SLC27A2/PNKD/ECI1/GCSH/ENO1/ETFB/TPI1/ECHS1 13 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 6/436 138/18722 0.103789751064863 0.430595690330768 BRCA1/FANCI/UBE2C/UBE2S/SAE1/RPS2 6 GO:0048872 homeostasis of number of cells 10/436 272/18722 0.104762170684945 0.434105081666724 HMGB2/HMGB1/EZH2/PRKDC/CCNB2/SLC25A5/FH/PRDX2/RPS17/BAX 10 GO:0000380 alternative mRNA splicing, via spliceosome 4/436 77/18722 0.104920469579845 0.434236587609708 SRSF2/RBM17/RBMX/KHDRBS1 4 GO:0010823 negative regulation of mitochondrion organization 3/436 49/18722 0.105632622860412 0.434562984453325 SLC25A5/PPIF/GPX1 3 GO:0030857 negative regulation of epithelial cell differentiation 3/436 49/18722 0.105632622860412 0.434562984453325 EZH2/ID1/CCND1 3 GO:0046605 regulation of centrosome cycle 3/436 49/18722 0.105632622860412 0.434562984453325 BRCA1/NUP62/CENPJ 3 GO:0070849 response to epidermal growth factor 3/436 49/18722 0.105632622860412 0.434562984453325 MCM7/ID1/GSTP1 3 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/436 49/18722 0.105632622860412 0.434562984453325 BRCA1/HMGB2/GPX1 3 GO:0034249 negative regulation of cellular amide metabolic process 10/436 273/18722 0.106629850956949 0.435090021651478 TYMS/DHFR/EXOSC9/EXOSC8/HNRNPR/EIF4EBP1/HNRNPD/RPS3/ILF3/YBX1 10 GO:0031639 plasminogen activation 2/436 24/18722 0.106775225365941 0.435090021651478 DHCR24/ENO1 2 GO:0044321 response to leptin 2/436 24/18722 0.106775225365941 0.435090021651478 CCNA2/CCND1 2 GO:0050855 regulation of B cell receptor signaling pathway 2/436 24/18722 0.106775225365941 0.435090021651478 CD81/SLC39A10 2 GO:0051570 regulation of histone H3-K9 methylation 2/436 24/18722 0.106775225365941 0.435090021651478 BRCA1/RIF1 2 GO:0070129 regulation of mitochondrial translation 2/436 24/18722 0.106775225365941 0.435090021651478 UQCC2/C1QBP 2 GO:0071294 cellular response to zinc ion 2/436 24/18722 0.106775225365941 0.435090021651478 MT2A/PARP1 2 GO:0071577 zinc ion transmembrane transport 2/436 24/18722 0.106775225365941 0.435090021651478 SLC39A1/SLC39A10 2 GO:0072593 reactive oxygen species metabolic process 9/436 239/18722 0.107429920924193 0.437238503785179 DHFR/BRCA1/FOXM1/PRDX2/GSTP1/VDAC1/PRDX4/HSPD1/GPX1 9 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 4/436 78/18722 0.108678840508569 0.441274676668519 BIRC5/DHCR24/BCL2L12/GPX1 4 GO:0090559 regulation of membrane permeability 4/436 78/18722 0.108678840508569 0.441274676668519 SLC25A5/PPIF/BAX/DYNLT1 4 GO:0002639 positive regulation of immunoglobulin production 3/436 50/18722 0.110537025736524 0.447231763327848 MSH2/RIF1/PHB2 3 GO:0019083 viral transcription 3/436 50/18722 0.110537025736524 0.447231763327848 JUN/NUCKS1/PSMC3 3 GO:0045814 negative regulation of gene expression, epigenetic 3/436 50/18722 0.110537025736524 0.447231763327848 HELLS/EZH2/POLE3 3 GO:0002456 T cell mediated immunity 5/436 109/18722 0.111053542163611 0.44879234766001 HMGB1/EMP2/CD81/HSPD1/CTSH 5 GO:0032355 response to estradiol 6/436 141/18722 0.111956274242782 0.451908208149394 PCNA/CCNA2/EZH2/HNRNPD/GSTP1/CCND1 6 GO:0007584 response to nutrient 7/436 174/18722 0.112732674747943 0.454069978248158 TYMS/HAT1/SRSF2/GSTP1/MGMT/CCND1/LDHA 7 GO:0009896 positive regulation of catabolic process 16/436 492/18722 0.113515592670212 0.454069978248158 DTL/HMGB1/BARD1/EXOSC9/EXOSC8/HNRNPR/SLC25A5/HSP90AA1/SVIP/HNRNPD/PSMC3/CD81/BAX/VDAC1/RDX/PHB2 16 GO:0000244 spliceosomal tri-snRNP complex assembly 2/436 25/18722 0.114344640398254 0.454069978248158 LSM2/SRSF10 2 GO:0034389 lipid droplet organization 2/436 25/18722 0.114344640398254 0.454069978248158 PPIA/SQLE 2 GO:0046039 GTP metabolic process 2/436 25/18722 0.114344640398254 0.454069978248158 RAN/NME1 2 GO:0051204 protein insertion into mitochondrial membrane 2/436 25/18722 0.114344640398254 0.454069978248158 HSP90AA1/BAX 2 GO:0051291 protein heterooligomerization 2/436 25/18722 0.114344640398254 0.454069978248158 RRM2/RRM1 2 GO:0051307 meiotic chromosome separation 2/436 25/18722 0.114344640398254 0.454069978248158 TOP2A/TTK 2 GO:0070199 establishment of protein localization to chromosome 2/436 25/18722 0.114344640398254 0.454069978248158 BRCA2/CCT5 2 GO:0071450 cellular response to oxygen radical 2/436 25/18722 0.114344640398254 0.454069978248158 DHFR/PRDX2 2 GO:0071451 cellular response to superoxide 2/436 25/18722 0.114344640398254 0.454069978248158 DHFR/PRDX2 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/436 25/18722 0.114344640398254 0.454069978248158 NUCKS1/SNX5 2 GO:1901798 positive regulation of signal transduction by p53 class mediator 2/436 25/18722 0.114344640398254 0.454069978248158 EEF1E1/RPS7 2 GO:1903901 negative regulation of viral life cycle 2/436 25/18722 0.114344640398254 0.454069978248158 PPIA/LY6E 2 GO:0031349 positive regulation of defense response 10/436 278/18722 0.11625342565372 0.461060884495556 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/XRCC5/DDT/CD81/XRCC6/HSPD1 10 GO:0009791 post-embryonic development 4/436 80/18722 0.116373863588794 0.461060884495556 HMGN1/BAX/C12orf57/EFEMP1 4 GO:0030010 establishment of cell polarity 6/436 143/18722 0.117577171042156 0.4652909732937 MAD2L1/NDC80/KIF20B/HSP90AA1/FAT1/DYNLT1 6 GO:2000106 regulation of leukocyte apoptotic process 4/436 81/18722 0.120308455770105 0.473952123958937 AURKB/CDKN2A/BAX/SLC39A10 4 GO:2001021 negative regulation of response to DNA damage stimulus 4/436 81/18722 0.120308455770105 0.473952123958937 FBXO5/RMI2/RPS3/RIF1 4 GO:0071453 cellular response to oxygen levels 7/436 177/18722 0.12031836198433 0.473952123958937 CCNA2/SLC29A1/EIF4EBP1/ENO1/CHCHD2/HILPDA/PHB2 7 GO:0071466 cellular response to xenobiotic stimulus 7/436 177/18722 0.12031836198433 0.473952123958937 PCNA/MCM7/VKORC1/NUDT15/GSTP1/NME1/GSTO1 7 GO:2000378 negative regulation of reactive oxygen species metabolic process 3/436 52/18722 0.120600821236526 0.474519974383626 BRCA1/VDAC1/HSPD1 3 GO:0001556 oocyte maturation 2/436 26/18722 0.122046423367843 0.475302245828684 FBXO5/BRCA2 2 GO:0002407 dendritic cell chemotaxis 2/436 26/18722 0.122046423367843 0.475302245828684 HMGB1/C1QBP 2 GO:0002418 immune response to tumor cell 2/436 26/18722 0.122046423367843 0.475302245828684 HMGB1/HSPD1 2 GO:0032682 negative regulation of chemokine production 2/436 26/18722 0.122046423367843 0.475302245828684 GSTP1/SUZ12 2 GO:0042278 purine nucleoside metabolic process 2/436 26/18722 0.122046423367843 0.475302245828684 NUDT1/MTAP 2 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/436 26/18722 0.122046423367843 0.475302245828684 CALM2/GSTO1 2 GO:0097066 response to thyroid hormone 2/436 26/18722 0.122046423367843 0.475302245828684 RDX/CTSH 2 GO:1904353 regulation of telomere capping 2/436 26/18722 0.122046423367843 0.475302245828684 AURKB/HNRNPD 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/436 26/18722 0.122046423367843 0.475302245828684 CDKN2A/BAX 2 GO:0002708 positive regulation of lymphocyte mediated immunity 5/436 113/18722 0.124137125409731 0.482896232744655 MSH2/CADM1/CD81/RIF1/HSPD1 5 GO:0009205 purine ribonucleoside triphosphate metabolic process 4/436 82/18722 0.124299688296828 0.482981008546338 PARP1/RAN/ENO1/NME1 4 GO:0051656 establishment of organelle localization 13/436 390/18722 0.125413776021728 0.486758671414648 CDCA5/MAD2L1/CDT1/NUF2/NUSAP1/CENPF/NDC80/AURKB/NUP62/KPNB1/RAN/KIF22/DYNLT1 13 GO:0032210 regulation of telomere maintenance via telomerase 3/436 53/18722 0.125754902218435 0.487531151990339 AURKB/XRCC5/CCT5 3 GO:0031331 positive regulation of cellular catabolic process 14/436 427/18722 0.126357489543723 0.489314386709385 HMGB1/EXOSC9/EXOSC8/HNRNPR/SLC25A5/HSP90AA1/SVIP/HNRNPD/PSMC3/CD81/BAX/VDAC1/RDX/PHB2 14 GO:1901214 regulation of neuron death 11/436 319/18722 0.127320135951397 0.491026474296894 MYBL2/MSH2/DHCR24/PARP1/PARP2/JUN/NAE1/SET/HRAS/BAX/HSPD1 11 GO:0002244 hematopoietic progenitor cell differentiation 5/436 114/18722 0.127515181754163 0.491026474296894 ESCO2/TOP2A/DHTKD1/PRKDC/XRCC5 5 GO:0022904 respiratory electron transport chain 5/436 114/18722 0.127515181754163 0.491026474296894 CDK1/CHCHD2/COX5A/COX8A/NDUFA4 5 GO:0051261 protein depolymerization 5/436 114/18722 0.127515181754163 0.491026474296894 STMN1/TPX2/CKAP2/HSPA8/RDX 5 GO:1903008 organelle disassembly 5/436 114/18722 0.127515181754163 0.491026474296894 CDK1/VRK1/SLC25A5/VDAC1/PHB2 5 GO:0043409 negative regulation of MAPK cascade 7/436 180/18722 0.128160471125923 0.491815826762385 PBK/FOXM1/NUP62/PPIA/GSTP1/MARVELD3/PEBP1 7 GO:0048678 response to axon injury 4/436 83/18722 0.128346473264108 0.491815826762385 CDK1/DHFR/NREP/BAX 4 GO:0001889 liver development 6/436 147/18722 0.129232089048469 0.491815826762385 TYMS/PCNA/EZH2/HNRNPD/HRAS/CCND1 6 GO:0016042 lipid catabolic process 11/436 320/18722 0.129276888366302 0.491815826762385 ACAT2/YWHAH/NUDT8/HADH/CDK4/SLC27A2/ECI1/PAFAH1B3/HINT2/ETFB/ECHS1 11 GO:0007026 negative regulation of microtubule depolymerization 2/436 27/18722 0.129870340730609 0.491815826762385 TPX2/CKAP2 2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 2/436 27/18722 0.129870340730609 0.491815826762385 CALM2/GSTO1 2 GO:0032781 positive regulation of ATPase activity 2/436 27/18722 0.129870340730609 0.491815826762385 DNAJC9/ATP1B3 2 GO:0032786 positive regulation of DNA-templated transcription, elongation 2/436 27/18722 0.129870340730609 0.491815826762385 SUPT16H/HMGN1 2 GO:0034698 response to gonadotropin 2/436 27/18722 0.129870340730609 0.491815826762385 CCNA2/CTSV 2 GO:0039529 RIG-I signaling pathway 2/436 27/18722 0.129870340730609 0.491815826762385 C1QBP/PHB2 2 GO:0042104 positive regulation of activated T cell proliferation 2/436 27/18722 0.129870340730609 0.491815826762385 HMGB1/RPS3 2 GO:0045830 positive regulation of isotype switching 2/436 27/18722 0.129870340730609 0.491815826762385 MSH2/RIF1 2 GO:0046174 polyol catabolic process 2/436 27/18722 0.129870340730609 0.491815826762385 IMPA2/TPI1 2 GO:0048873 homeostasis of number of cells within a tissue 2/436 27/18722 0.129870340730609 0.491815826762385 FH/BAX 2 GO:0070861 regulation of protein exit from endoplasmic reticulum 2/436 27/18722 0.129870340730609 0.491815826762385 SVIP/CD81 2 GO:0010524 positive regulation of calcium ion transport into cytosol 3/436 54/18722 0.130986874799239 0.493863700479328 CALM2/BAX/GSTO1 3 GO:0030520 intracellular estrogen receptor signaling pathway 3/436 54/18722 0.130986874799239 0.493863700479328 BRCA1/PARP1/PHB2 3 GO:0070228 regulation of lymphocyte apoptotic process 3/436 54/18722 0.130986874799239 0.493863700479328 AURKB/BAX/SLC39A10 3 GO:0072698 protein localization to microtubule cytoskeleton 3/436 54/18722 0.130986874799239 0.493863700479328 KIF20B/TTK/NUP62 3 GO:1903900 regulation of viral life cycle 6/436 148/18722 0.132230010218439 0.497186068263228 TOP2A/HACD3/PPIA/LY6E/SRPK1/ILF3 6 GO:0006970 response to osmotic stress 4/436 84/18722 0.132447702242084 0.497186068263228 XRCC5/MARVELD3/BAX/XRCC6 4 GO:0061157 mRNA destabilization 4/436 84/18722 0.132447702242084 0.497186068263228 EXOSC9/EXOSC8/HNRNPR/HNRNPD 4 GO:0098586 cellular response to virus 4/436 84/18722 0.132447702242084 0.497186068263228 HSP90AA1/BAX/C1QBP/PHB2 4 GO:0002377 immunoglobulin production 8/436 216/18722 0.132860913030738 0.498192123069356 UNG/MSH2/MSH6/PRKDC/CTNNBL1/RIF1/HSPD1/PHB2 8 GO:0009260 ribonucleotide biosynthetic process 7/436 182/18722 0.133528244732865 0.500147824976486 GMPS/PAICS/PARP1/SLC25A1/ENO1/NME1/MPC2 7 GO:0007006 mitochondrial membrane organization 5/436 116/18722 0.134395962873299 0.501754677495417 SLC25A5/PPIF/HSP90AA1/BAX/DYNLT1 5 GO:0030518 intracellular steroid hormone receptor signaling pathway 5/436 116/18722 0.134395962873299 0.501754677495417 BRCA1/YWHAH/PARP1/PTGES3/PHB2 5 GO:0035967 cellular response to topologically incorrect protein 5/436 116/18722 0.134395962873299 0.501754677495417 SDF2L1/HSPA8/CCND1/BAX/HSPD1 5 GO:0051592 response to calcium ion 6/436 149/18722 0.135260923304998 0.504435030282008 FUS/CALM2/CACYBP/PPIF/HNRNPD/CCND1 6 GO:1905517 macrophage migration 3/436 55/18722 0.136294055207292 0.506881413970158 CKLF/DDT/CD81 3 GO:0000303 response to superoxide 2/436 28/18722 0.137806561818024 0.506881413970158 DHFR/PRDX2 2 GO:0000470 maturation of LSU-rRNA 2/436 28/18722 0.137806561818024 0.506881413970158 RPL35/RPL7A 2 GO:0006829 zinc ion transport 2/436 28/18722 0.137806561818024 0.506881413970158 SLC39A1/SLC39A10 2 GO:0006972 hyperosmotic response 2/436 28/18722 0.137806561818024 0.506881413970158 XRCC5/XRCC6 2 GO:0007141 male meiosis I 2/436 28/18722 0.137806561818024 0.506881413970158 BRCA2/RAD51C 2 GO:0030262 apoptotic nuclear changes 2/436 28/18722 0.137806561818024 0.506881413970158 TOP2A/BAX 2 GO:0032607 interferon-alpha production 2/436 28/18722 0.137806561818024 0.506881413970158 HMGB1/HSPD1 2 GO:0032647 regulation of interferon-alpha production 2/436 28/18722 0.137806561818024 0.506881413970158 HMGB1/HSPD1 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 2/436 28/18722 0.137806561818024 0.506881413970158 NUP62/SNX5 2 GO:0062125 regulation of mitochondrial gene expression 2/436 28/18722 0.137806561818024 0.506881413970158 UQCC2/C1QBP 2 GO:0090200 positive regulation of release of cytochrome c from mitochondria 2/436 28/18722 0.137806561818024 0.506881413970158 PPIF/BAX 2 GO:0007163 establishment or maintenance of cell polarity 8/436 218/18722 0.137837469902115 0.506881413970158 MAD2L1/NDC80/KIF20B/HSP90AA1/FAT1/PDLIM1/DYNLT1/SPINT2 8 GO:0061008 hepaticobiliary system development 6/436 150/18722 0.138324468566072 0.50812767842633 TYMS/PCNA/EZH2/HNRNPD/HRAS/CCND1 6 GO:0070997 neuron death 12/436 361/18722 0.138856181409298 0.509535356593905 MYBL2/MSH2/DHCR24/PARP1/PARP2/JUN/NAE1/SET/HRAS/BAX/HSPD1/GPX1 12 GO:2000117 negative regulation of cysteine-type endopeptidase activity 4/436 86/18722 0.140808964414567 0.516149099258953 BIRC5/DHCR24/BCL2L12/GPX1 4 GO:0034504 protein localization to nucleus 10/436 290/18722 0.141251815248376 0.516559676563238 CDK1/BARD1/NUP62/KPNB1/PARP1/RAN/NXT1/CSE1L/CCT5/PHB2 10 GO:0031529 ruffle organization 3/436 56/18722 0.141673755653165 0.516559676563238 HRAS/TACSTD2/RDX 3 GO:0032608 interferon-beta production 3/436 56/18722 0.141673755653165 0.516559676563238 HMGB2/HMGB1/HSP90AA1 3 GO:0032648 regulation of interferon-beta production 3/436 56/18722 0.141673755653165 0.516559676563238 HMGB2/HMGB1/HSP90AA1 3 GO:0048255 mRNA stabilization 3/436 56/18722 0.141673755653165 0.516559676563238 FUS/HNRNPD/YBX1 3 GO:1903362 regulation of cellular protein catabolic process 9/436 255/18722 0.142558457896175 0.519233618940313 PBK/NUDT15/HSP90AA1/SVIP/PSMC3/CD81/RPS7/RDX/GPX1 9 GO:0002831 regulation of response to biotic stimulus 11/436 327/18722 0.143431598022445 0.521859822709446 HMGB2/HMGB1/HERC5/PRKDC/CADM1/HSP90AA1/XRCC5/PRDX2/C1QBP/XRCC6/HSPD1 11 GO:0050673 epithelial cell proliferation 14/436 437/18722 0.143626441624924 0.522015170778724 HMGB2/HMGB1/BRCA2/ID1/PRKDC/HMGN1/MARVELD3/NME1/HRAS/CCND1/SUZ12/BAX/PHB2/GPX1 14 GO:0031056 regulation of histone modification 6/436 152/18722 0.144547969415949 0.523919806524661 BRCA1/CHEK1/SET/EID1/RIF1/BRD7 6 GO:0032259 methylation 12/436 364/18722 0.144720594813977 0.523919806524661 TYMS/HELLS/BRCA1/EZH2/PARP1/COMTD1/SNRPB/MTAP/MGMT/SUZ12/RIF1/SNRPD3 12 GO:0031398 positive regulation of protein ubiquitination 5/436 119/18722 0.145019859094292 0.523919806524661 BRCA1/FANCI/UBE2C/UBE2S/RPS2 5 GO:0061014 positive regulation of mRNA catabolic process 4/436 87/18722 0.145066690818545 0.523919806524661 EXOSC9/EXOSC8/HNRNPR/HNRNPD 4 GO:1900182 positive regulation of protein localization to nucleus 4/436 87/18722 0.145066690818545 0.523919806524661 CDK1/PARP1/RAN/CCT5 4 GO:2000177 regulation of neural precursor cell proliferation 4/436 87/18722 0.145066690818545 0.523919806524661 SHCBP1/ASPM/NAP1L1/SPINT2 4 GO:0000305 response to oxygen radical 2/436 29/18722 0.145845645694359 0.525626481488807 DHFR/PRDX2 2 GO:0035066 positive regulation of histone acetylation 2/436 29/18722 0.145845645694359 0.525626481488807 BRCA1/BRD7 2 GO:0050779 RNA destabilization 4/436 88/18722 0.149374250361296 0.537778649516901 EXOSC9/EXOSC8/HNRNPR/HNRNPD 4 GO:0051604 protein maturation 10/436 294/18722 0.150163470829828 0.539912582896579 DHCR24/PARP1/BCL2L12/GCSH/ENO1/SEC11A/PRDX4/PERP/HSPD1/CTSH 10 GO:0006575 cellular modified amino acid metabolic process 7/436 188/18722 0.150281701155999 0.539912582896579 TYMS/DHFR/MTHFD2/GGH/GSTP1/GSTO1/GPX1 7 GO:0016052 carbohydrate catabolic process 6/436 154/18722 0.150897449685991 0.540184387483244 HMGB1/DHTKD1/ENO1/TPI1/LDHA/PGAM1 6 GO:0042752 regulation of circadian rhythm 5/436 121/18722 0.152297011863101 0.540184387483244 CDK1/TOP2A/EZH2/PRKDC/HNRNPD 5 GO:0002931 response to ischemia 3/436 58/18722 0.152639966974622 0.540184387483244 EIF4EBP1/PPIF/HSPD1 3 GO:0010043 response to zinc ion 3/436 58/18722 0.152639966974622 0.540184387483244 MT2A/PARP1/GGH 3 GO:0032387 negative regulation of intracellular transport 3/436 58/18722 0.152639966974622 0.540184387483244 BARD1/SVIP/LMAN1 3 GO:0042743 hydrogen peroxide metabolic process 3/436 58/18722 0.152639966974622 0.540184387483244 PRDX2/PRDX4/GPX1 3 GO:0043525 positive regulation of neuron apoptotic process 3/436 58/18722 0.152639966974622 0.540184387483244 MYBL2/JUN/BAX 3 GO:0043666 regulation of phosphoprotein phosphatase activity 3/436 58/18722 0.152639966974622 0.540184387483244 MASTL/CALM2/SLC39A10 3 GO:0044380 protein localization to cytoskeleton 3/436 58/18722 0.152639966974622 0.540184387483244 KIF20B/TTK/NUP62 3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 3/436 58/18722 0.152639966974622 0.540184387483244 RPS3/BAX/RPS7 3 GO:0032984 protein-containing complex disassembly 8/436 224/18722 0.153318052509972 0.540184387483244 STMN1/TPX2/SUPT16H/CKAP2/SET/HSPA8/HMGA1/RDX 8 GO:0009199 ribonucleoside triphosphate metabolic process 4/436 89/18722 0.15373045280853 0.540184387483244 PARP1/RAN/ENO1/NME1 4 GO:1900407 regulation of cellular response to oxidative stress 4/436 89/18722 0.15373045280853 0.540184387483244 DHFR/PARP1/PPIA/GPX1 4 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 2/436 30/18722 0.153978528405308 0.540184387483244 TOP2A/BAX 2 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/436 30/18722 0.153978528405308 0.540184387483244 CALM2/GSTO1 2 GO:0019674 NAD metabolic process 2/436 30/18722 0.153978528405308 0.540184387483244 ENO1/LDHA 2 GO:0044030 regulation of DNA methylation 2/436 30/18722 0.153978528405308 0.540184387483244 BRCA1/PARP1 2 GO:0046825 regulation of protein export from nucleus 2/436 30/18722 0.153978528405308 0.540184387483244 BARD1/ANP32B 2 GO:0048147 negative regulation of fibroblast proliferation 2/436 30/18722 0.153978528405308 0.540184387483244 GSTP1/BAX 2 GO:0060218 hematopoietic stem cell differentiation 2/436 30/18722 0.153978528405308 0.540184387483244 PRKDC/XRCC5 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/436 30/18722 0.153978528405308 0.540184387483244 AURKB/SLC39A10 2 GO:0090151 establishment of protein localization to mitochondrial membrane 2/436 30/18722 0.153978528405308 0.540184387483244 HSP90AA1/BAX 2 GO:1903579 negative regulation of ATP metabolic process 2/436 30/18722 0.153978528405308 0.540184387483244 PARP1/PPIF 2 GO:0046390 ribose phosphate biosynthetic process 7/436 190/18722 0.156076115840513 0.546983813532992 GMPS/PAICS/PARP1/SLC25A1/ENO1/NME1/MPC2 7 GO:0035304 regulation of protein dephosphorylation 4/436 90/18722 0.158134095524222 0.552244803082142 MASTL/CALM2/PPIA/SLC39A10 4 GO:0006767 water-soluble vitamin metabolic process 3/436 59/18722 0.158221113794738 0.552244803082142 DHFR/MTHFD2/GSTO1 3 GO:0035306 positive regulation of dephosphorylation 3/436 59/18722 0.158221113794738 0.552244803082142 CALM2/PPIA/SLC39A10 3 GO:0090303 positive regulation of wound healing 3/436 59/18722 0.158221113794738 0.552244803082142 HMGB1/PRDX2/HRAS 3 GO:0006164 purine nucleotide biosynthetic process 7/436 191/18722 0.159011460733667 0.55387646880935 GMPS/PAICS/PARP1/SLC25A1/ENO1/NME1/MPC2 7 GO:0050821 protein stabilization 7/436 191/18722 0.159011460733667 0.55387646880935 HSP90AA1/ATP1B3/RPS7/CCT5/PTGES3/HSPD1/PHB2 7 GO:0002262 myeloid cell homeostasis 6/436 157/18722 0.160650840988119 0.559019305710177 HMGB2/HMGB1/PRKDC/SLC25A5/RPS17/BAX 6 GO:0032872 regulation of stress-activated MAPK cascade 7/436 192/18722 0.161971847676765 0.562117401911663 PBK/HMGB1/FOXM1/PPIA/GSTP1/MARVELD3/HRAS 7 GO:0018200 peptidyl-glutamic acid modification 2/436 31/18722 0.162196510606979 0.562117401911663 PARP1/VKORC1 2 GO:0031114 regulation of microtubule depolymerization 2/436 31/18722 0.162196510606979 0.562117401911663 TPX2/CKAP2 2 GO:0034472 snRNA 3'-end processing 2/436 31/18722 0.162196510606979 0.562117401911663 EXOSC9/EXOSC8 2 GO:0001909 leukocyte mediated cytotoxicity 5/436 124/18722 0.163491539618904 0.565463177855301 TUBB/TUBB4B/EMP2/CADM1/CTSH 5 GO:0010508 positive regulation of autophagy 5/436 124/18722 0.163491539618904 0.565463177855301 HMGB1/SLC25A5/SVIP/VDAC1/PHB2 5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 3/436 60/18722 0.163864058776705 0.565611253181968 SRSF2/RBMX/KHDRBS1 3 GO:0042306 regulation of protein import into nucleus 3/436 60/18722 0.163864058776705 0.565611253181968 CDK1/NUP62/RAN 3 GO:0006497 protein lipidation 4/436 92/18722 0.16707883667318 0.574658350439646 ZDHHC12/SVIP/PGAP2/DBI 4 GO:0048525 negative regulation of viral process 4/436 92/18722 0.16707883667318 0.574658350439646 PPIA/LY6E/SRPK1/ILF3 4 GO:0018209 peptidyl-serine modification 11/436 338/18722 0.167243278201758 0.574658350439646 CLSPN/CDK1/VRK1/MASTL/AURKB/TTK/PRKDC/PARP1/PARP2/HSP90AA1/BAX 11 GO:0035966 response to topologically incorrect protein 6/436 159/18722 0.167300977821632 0.574658350439646 SDF2L1/HSP90AA1/HSPA8/CCND1/BAX/HSPD1 6 GO:0002253 activation of immune response 12/436 375/18722 0.167322556715012 0.574658350439646 HMGB1/PRKDC/HSP90AA1/XRCC5/CD81/HRAS/RPS3/BAX/SLC39A10/C1QBP/XRCC6/KHDRBS1 12 GO:0002285 lymphocyte activation involved in immune response 7/436 194/18722 0.167966564444867 0.576293282610339 UNG/HMGB1/MSH2/MSH6/CD81/RIF1/HSPD1 7 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 2/436 32/18722 0.170491245564505 0.581466663550513 EZH2/SUPT16H 2 GO:0050685 positive regulation of mRNA processing 2/436 32/18722 0.170491245564505 0.581466663550513 HSPA8/RBMX 2 GO:0051497 negative regulation of stress fiber assembly 2/436 32/18722 0.170491245564505 0.581466663550513 STMN1/TACSTD2 2 GO:0051642 centrosome localization 2/436 32/18722 0.170491245564505 0.581466663550513 MAD2L1/ASPM 2 GO:0097345 mitochondrial outer membrane permeabilization 2/436 32/18722 0.170491245564505 0.581466663550513 SLC25A5/BAX 2 GO:1901185 negative regulation of ERBB signaling pathway 2/436 32/18722 0.170491245564505 0.581466663550513 NUP62/SNX5 2 GO:0070302 regulation of stress-activated protein kinase signaling cascade 7/436 195/18722 0.171000288870846 0.582623625735721 PBK/HMGB1/FOXM1/PPIA/GSTP1/MARVELD3/HRAS 7 GO:0097306 cellular response to alcohol 4/436 93/18722 0.171617478915134 0.583567462990905 RAD51/BLM/BRCA1/CDK4 4 GO:1901796 regulation of signal transduction by p53 class mediator 4/436 93/18722 0.171617478915134 0.583567462990905 CHEK1/AURKB/EEF1E1/RPS7 4 GO:0050708 regulation of protein secretion 9/436 268/18722 0.17488622972497 0.593233866956242 HADH/PPIA/UQCC2/IDH2/DNAJC1/MYH10/MPC2/WLS/ERP29 9 GO:0032615 interleukin-12 production 3/436 62/18722 0.175324727803448 0.593233866956242 HMGB1/C1QBP/HSPD1 3 GO:0032655 regulation of interleukin-12 production 3/436 62/18722 0.175324727803448 0.593233866956242 HMGB1/C1QBP/HSPD1 3 GO:0046148 pigment biosynthetic process 3/436 62/18722 0.175324727803448 0.593233866956242 GMPS/PAICS/DDT 3 GO:0046173 polyol biosynthetic process 3/436 62/18722 0.175324727803448 0.593233866956242 DHFR/PGP/IMPA2 3 GO:0051346 negative regulation of hydrolase activity 12/436 379/18722 0.175955758989514 0.594432225081369 BIRC5/MASTL/GCHFR/DHCR24/PPIF/BCL2L12/HRAS/PEBP1/SPINT2/RDX/APLP2/GPX1 12 GO:0032091 negative regulation of protein binding 4/436 94/18722 0.176198651386696 0.594432225081369 AURKB/ID1/BAX/LRPAP1 4 GO:1902414 protein localization to cell junction 4/436 94/18722 0.176198651386696 0.594432225081369 NSG1/ZDHHC12/MARVELD3/HRAS 4 GO:0034250 positive regulation of cellular amide metabolic process 6/436 162/18722 0.177489220052641 0.595199389026435 PRKDC/CDK4/HNRNPD/UQCC2/C1QBP/KHDRBS1 6 GO:0051494 negative regulation of cytoskeleton organization 6/436 162/18722 0.177489220052641 0.595199389026435 BRCA1/STMN1/TPX2/CKAP2/TACSTD2/RDX 6 GO:0001881 receptor recycling 2/436 33/18722 0.178854727509838 0.595199389026435 NSG1/PLEKHJ1 2 GO:0003382 epithelial cell morphogenesis 2/436 33/18722 0.178854727509838 0.595199389026435 FAT1/SPINT2 2 GO:0009156 ribonucleoside monophosphate biosynthetic process 2/436 33/18722 0.178854727509838 0.595199389026435 GMPS/PAICS 2 GO:0036336 dendritic cell migration 2/436 33/18722 0.178854727509838 0.595199389026435 HMGB1/C1QBP 2 GO:0040020 regulation of meiotic nuclear division 2/436 33/18722 0.178854727509838 0.595199389026435 RAD51AP1/FBXO5 2 GO:0045648 positive regulation of erythrocyte differentiation 2/436 33/18722 0.178854727509838 0.595199389026435 HMGB2/PRKDC 2 GO:0046685 response to arsenic-containing substance 2/436 33/18722 0.178854727509838 0.595199389026435 PPIF/GSTO1 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/436 33/18722 0.178854727509838 0.595199389026435 HMGB1/CDK4 2 GO:0061842 microtubule organizing center localization 2/436 33/18722 0.178854727509838 0.595199389026435 MAD2L1/ASPM 2 GO:1902275 regulation of chromatin organization 2/436 33/18722 0.178854727509838 0.595199389026435 MKI67/SSRP1 2 GO:1903146 regulation of autophagy of mitochondrion 2/436 33/18722 0.178854727509838 0.595199389026435 SLC25A5/VDAC1 2 GO:1903715 regulation of aerobic respiration 2/436 33/18722 0.178854727509838 0.595199389026435 PPIF/UQCC2 2 GO:0036473 cell death in response to oxidative stress 4/436 95/18722 0.180821107563678 0.599885788242644 MELK/PARP1/PPIA/GPX1 4 GO:0001666 response to hypoxia 10/436 307/18722 0.181011867951411 0.599885788242644 CCNA2/SLC29A1/EIF4EBP1/ENO1/CHCHD2/HILPDA/PDLIM1/LDHA/HSPD1/PHB2 10 GO:0050854 regulation of antigen receptor-mediated signaling pathway 3/436 63/18722 0.181137183509 0.599885788242644 CD81/RPS3/SLC39A10 3 GO:1902373 negative regulation of mRNA catabolic process 3/436 63/18722 0.181137183509 0.599885788242644 FUS/HNRNPD/YBX1 3 GO:2000242 negative regulation of reproductive process 3/436 63/18722 0.181137183509 0.599885788242644 FBXO5/TTK/PRDX4 3 GO:0034620 cellular response to unfolded protein 4/436 96/18722 0.185483595550563 0.611375081708796 HSPA8/CCND1/BAX/HSPD1 4 GO:0042158 lipoprotein biosynthetic process 4/436 96/18722 0.185483595550563 0.611375081708796 ZDHHC12/SVIP/PGAP2/DBI 4 GO:0043648 dicarboxylic acid metabolic process 4/436 96/18722 0.185483595550563 0.611375081708796 DHFR/MTHFD2/FH/IDH2 4 GO:0046395 carboxylic acid catabolic process 8/436 236/18722 0.186615989783989 0.611375081708796 ACAT2/NUDT8/HADH/SLC27A2/ECI1/GCSH/ETFB/ECHS1 8 GO:0006352 DNA-templated transcription, initiation 5/436 130/18722 0.186816294485507 0.611375081708796 HMGB1/TFAM/CDK4/JUN/POLR2I 5 GO:0006749 glutathione metabolic process 3/436 64/18722 0.187000905507027 0.611375081708796 GSTP1/GSTO1/GPX1 3 GO:0016126 sterol biosynthetic process 3/436 64/18722 0.187000905507027 0.611375081708796 FDPS/DHCR24/SQLE 3 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 3/436 64/18722 0.187000905507027 0.611375081708796 PBK/SVIP/RPS7 3 GO:0022412 cellular process involved in reproduction in multicellular organism 12/436 384/18722 0.187044751324817 0.611375081708796 HMGB2/TOP2A/FBXO5/MSH2/BRCA2/TTK/ASPM/RAD51C/CCNB2/SRPK1/BAX/PRDX4 12 GO:0000038 very long-chain fatty acid metabolic process 2/436 34/18722 0.18727928034857 0.611375081708796 HACD3/SLC27A2 2 GO:0010922 positive regulation of phosphatase activity 2/436 34/18722 0.18727928034857 0.611375081708796 CALM2/SLC39A10 2 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/436 34/18722 0.18727928034857 0.611375081708796 CALM2/GSTO1 2 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2/436 34/18722 0.18727928034857 0.611375081708796 C1QBP/PHB2 2 GO:2000758 positive regulation of peptidyl-lysine acetylation 2/436 34/18722 0.18727928034857 0.611375081708796 BRCA1/BRD7 2 GO:2000780 negative regulation of double-strand break repair 2/436 34/18722 0.18727928034857 0.611375081708796 RMI2/RIF1 2 GO:0070482 response to oxygen levels 11/436 347/18722 0.188074751534962 0.613388281859748 CCNA2/SLC29A1/CDK4/EIF4EBP1/ENO1/CHCHD2/HILPDA/PDLIM1/LDHA/HSPD1/PHB2 11 GO:1901617 organic hydroxy compound biosynthetic process 8/436 237/18722 0.189522362462632 0.617522531442821 DHFR/PGP/IMPA2/FDPS/DHCR24/SLC27A2/DDT/SQLE 8 GO:1901216 positive regulation of neuron death 4/436 97/18722 0.190184859143025 0.619093217950397 MYBL2/PARP1/JUN/BAX 4 GO:1902904 negative regulation of supramolecular fiber organization 6/436 166/18722 0.191451946769932 0.622627136841361 STMN1/TPX2/CKAP2/HSPA8/TACSTD2/RDX 6 GO:0048608 reproductive structure development 13/436 424/18722 0.192048861805811 0.623976936416417 RRM1/HMGB2/NASP/MSH2/BRCA2/ASPM/DHCR24/NUDT1/CTSV/CCND1/BAX/PRDX4/SPINT2 13 GO:0035418 protein localization to synapse 3/436 65/18722 0.192913309542396 0.625009976430556 NSG1/ZDHHC12/HRAS 3 GO:0043489 RNA stabilization 3/436 65/18722 0.192913309542396 0.625009976430556 FUS/HNRNPD/YBX1 3 GO:0070936 protein K48-linked ubiquitination 3/436 65/18722 0.192913309542396 0.625009976430556 UBE2T/UBE2C/PPIA 3 GO:1902882 regulation of response to oxidative stress 4/436 98/18722 0.194923638859233 0.627118714050308 DHFR/PARP1/PPIA/GPX1 4 GO:0051403 stress-activated MAPK cascade 8/436 239/18722 0.19539219179464 0.627118714050308 PBK/HMGB1/FOXM1/HACD3/PPIA/GSTP1/MARVELD3/HRAS 8 GO:0006084 acetyl-CoA metabolic process 2/436 35/18722 0.195757546705881 0.627118714050308 NUDT8/MPC2 2 GO:0006471 protein ADP-ribosylation 2/436 35/18722 0.195757546705881 0.627118714050308 PARP1/PARP2 2 GO:0006739 NADP metabolic process 2/436 35/18722 0.195757546705881 0.627118714050308 IDH2/PGAM1 2 GO:0007020 microtubule nucleation 2/436 35/18722 0.195757546705881 0.627118714050308 TPX2/CENPJ 2 GO:0021955 central nervous system neuron axonogenesis 2/436 35/18722 0.195757546705881 0.627118714050308 HSP90AA1/C12orf57 2 GO:0032232 negative regulation of actin filament bundle assembly 2/436 35/18722 0.195757546705881 0.627118714050308 STMN1/TACSTD2 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/436 35/18722 0.195757546705881 0.627118714050308 PBK/SVIP 2 GO:0060236 regulation of mitotic spindle organization 2/436 35/18722 0.195757546705881 0.627118714050308 TPX2/NUP62 2 GO:0098801 regulation of renal system process 2/436 35/18722 0.195757546705881 0.627118714050308 EMP2/SNX5 2 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 2/436 35/18722 0.195757546705881 0.627118714050308 CALM2/GSTO1 2 GO:0051701 biological process involved in interaction with host 7/436 203/18722 0.196100891269758 0.627632610024757 CDK1/SIVA1/PPIA/LY6E/CD81/DYNLT1/PHB2 7 GO:0045861 negative regulation of proteolysis 11/436 351/18722 0.197699598508777 0.632138575921053 PBK/BIRC5/DHCR24/SVIP/BCL2L12/DNAJC1/PEBP1/RPS7/SPINT2/APLP2/GPX1 11 GO:0016054 organic acid catabolic process 8/436 240/18722 0.198355135936351 0.632138575921053 ACAT2/NUDT8/HADH/SLC27A2/ECI1/GCSH/ETFB/ECHS1 8 GO:0002706 regulation of lymphocyte mediated immunity 6/436 168/18722 0.198586936692761 0.632138575921053 HMGB1/MSH2/CADM1/CD81/RIF1/HSPD1 6 GO:0016482 cytosolic transport 6/436 168/18722 0.198586936692761 0.632138575921053 EMP2/SRSF10/SNX5/PLEKHJ1/RDX/VPS29 6 GO:2000241 regulation of reproductive process 6/436 168/18722 0.198586936692761 0.632138575921053 RAD51AP1/FBXO5/TTK/ASPM/C1QBP/PRDX4 6 GO:0061458 reproductive system development 13/436 427/18722 0.198614218840832 0.632138575921053 RRM1/HMGB2/NASP/MSH2/BRCA2/ASPM/DHCR24/NUDT1/CTSV/CCND1/BAX/PRDX4/SPINT2 13 GO:0046626 regulation of insulin receptor signaling pathway 3/436 66/18722 0.198871835108897 0.632371887172036 CDK4/NUCKS1/SNX5 3 GO:0042100 B cell proliferation 4/436 99/18722 0.199698672940064 0.634413098941999 CD81/BAX/SLC39A10/HSPD1 4 GO:0006631 fatty acid metabolic process 12/436 390/18722 0.200771377930814 0.635258385137634 BRCA1/ACAT2/NUDT8/HADH/HACD3/SLC27A2/ECI1/GSTP1/ETFB/ECHS1/PTGES3/GPX1 12 GO:0002705 positive regulation of leukocyte mediated immunity 5/436 134/18722 0.202997117960455 0.635258385137634 MSH2/CADM1/CD81/RIF1/HSPD1 5 GO:0098727 maintenance of cell number 5/436 134/18722 0.202997117960455 0.635258385137634 EZH2/SMC3/ASPM/SMC1A/RIF1 5 GO:0042176 regulation of protein catabolic process 12/436 391/18722 0.203102185086641 0.635258385137634 DTL/MAD2L1/PBK/BARD1/NUDT15/HSP90AA1/SVIP/PSMC3/CD81/RPS7/RDX/GPX1 12 GO:0016180 snRNA processing 2/436 36/18722 0.204282477302018 0.635258385137634 EXOSC9/EXOSC8 2 GO:0017004 cytochrome complex assembly 2/436 36/18722 0.204282477302018 0.635258385137634 UQCC2/COX14 2 GO:0044743 protein transmembrane import into intracellular organelle 2/436 36/18722 0.204282477302018 0.635258385137634 TOMM40/HSPD1 2 GO:0045191 regulation of isotype switching 2/436 36/18722 0.204282477302018 0.635258385137634 MSH2/RIF1 2 GO:0051385 response to mineralocorticoid 2/436 36/18722 0.204282477302018 0.635258385137634 PARP1/CCND1 2 GO:0090322 regulation of superoxide metabolic process 2/436 36/18722 0.204282477302018 0.635258385137634 DHFR/GSTP1 2 GO:1903539 protein localization to postsynaptic membrane 2/436 36/18722 0.204282477302018 0.635258385137634 NSG1/HRAS 2 GO:0061077 chaperone-mediated protein folding 3/436 67/18722 0.204873947325051 0.635258385137634 SDF2L1/HSPA8/PTGES3 3 GO:0016064 immunoglobulin mediated immune response 7/436 207/18722 0.209170193056585 0.635258385137634 UNG/MSH2/MSH6/CD81/RIF1/C1QBP/HSPD1 7 GO:0000255 allantoin metabolic process 1/436 10/18722 0.209976795673365 0.635258385137634 DNPH1 1 GO:0000338 protein deneddylation 1/436 10/18722 0.209976795673365 0.635258385137634 COPS3 1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1/436 10/18722 0.209976795673365 0.635258385137634 CD81 1 GO:0002934 desmosome organization 1/436 10/18722 0.209976795673365 0.635258385137634 PERP 1 GO:0006228 UTP biosynthetic process 1/436 10/18722 0.209976795673365 0.635258385137634 NME1 1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1/436 10/18722 0.209976795673365 0.635258385137634 TSEN34 1 GO:0006735 NADH regeneration 1/436 10/18722 0.209976795673365 0.635258385137634 ENO1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/436 10/18722 0.209976795673365 0.635258385137634 DTYMK 1 GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 1/436 10/18722 0.209976795673365 0.635258385137634 DNPH1 1 GO:0009396 folic acid-containing compound biosynthetic process 1/436 10/18722 0.209976795673365 0.635258385137634 DHFR 1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 1/436 10/18722 0.209976795673365 0.635258385137634 PRDX4 1 GO:0019062 virion attachment to host cell 1/436 10/18722 0.209976795673365 0.635258385137634 CD81 1 GO:0030638 polyketide metabolic process 1/436 10/18722 0.209976795673365 0.635258385137634 AKR7A2 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/436 10/18722 0.209976795673365 0.635258385137634 AKR7A2 1 GO:0034085 establishment of sister chromatid cohesion 1/436 10/18722 0.209976795673365 0.635258385137634 CDCA5 1 GO:0035520 monoubiquitinated protein deubiquitination 1/436 10/18722 0.209976795673365 0.635258385137634 USP1 1 GO:0043101 purine-containing compound salvage 1/436 10/18722 0.209976795673365 0.635258385137634 MTAP 1 GO:0044598 doxorubicin metabolic process 1/436 10/18722 0.209976795673365 0.635258385137634 AKR7A2 1 GO:0045792 negative regulation of cell size 1/436 10/18722 0.209976795673365 0.635258385137634 RDX 1 GO:0045835 negative regulation of meiotic nuclear division 1/436 10/18722 0.209976795673365 0.635258385137634 FBXO5 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/436 10/18722 0.209976795673365 0.635258385137634 HMGB1 1 GO:0048241 epinephrine transport 1/436 10/18722 0.209976795673365 0.635258385137634 LY6E 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/436 10/18722 0.209976795673365 0.635258385137634 CALM2 1 GO:0051660 establishment of centrosome localization 1/436 10/18722 0.209976795673365 0.635258385137634 MAD2L1 1 GO:0060068 vagina development 1/436 10/18722 0.209976795673365 0.635258385137634 BAX 1 GO:0061621 canonical glycolysis 1/436 10/18722 0.209976795673365 0.635258385137634 ENO1 1 GO:0061718 glucose catabolic process to pyruvate 1/436 10/18722 0.209976795673365 0.635258385137634 ENO1 1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/436 10/18722 0.209976795673365 0.635258385137634 SVIP 1 GO:0098885 modification of postsynaptic actin cytoskeleton 1/436 10/18722 0.209976795673365 0.635258385137634 MYH10 1 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/436 10/18722 0.209976795673365 0.635258385137634 NSG1 1 GO:1901993 regulation of meiotic cell cycle phase transition 1/436 10/18722 0.209976795673365 0.635258385137634 TTK 1 GO:1902946 protein localization to early endosome 1/436 10/18722 0.209976795673365 0.635258385137634 RDX 1 GO:1904350 regulation of protein catabolic process in the vacuole 1/436 10/18722 0.209976795673365 0.635258385137634 CD81 1 GO:1904779 regulation of protein localization to centrosome 1/436 10/18722 0.209976795673365 0.635258385137634 NUP62 1 GO:1904851 positive regulation of establishment of protein localization to telomere 1/436 10/18722 0.209976795673365 0.635258385137634 CCT5 1 GO:2000121 regulation of removal of superoxide radicals 1/436 10/18722 0.209976795673365 0.635258385137634 DHFR 1 GO:2000425 regulation of apoptotic cell clearance 1/436 10/18722 0.209976795673365 0.635258385137634 HMGB1 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/436 10/18722 0.209976795673365 0.635258385137634 C1QBP 1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/436 10/18722 0.209976795673365 0.635258385137634 BAX 1 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 11/436 356/18722 0.210030583912215 0.635258385137634 UNG/HMGB1/MSH2/MSH6/EMP2/CD81/HRAS/RIF1/C1QBP/HSPD1/CTSH 11 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 3/436 68/18722 0.210917138673862 0.635258385137634 PARP1/ENO1/NME1 3 GO:0032922 circadian regulation of gene expression 3/436 68/18722 0.210917138673862 0.635258385137634 ID1/ID4/ID3 3 GO:0042267 natural killer cell mediated cytotoxicity 3/436 68/18722 0.210917138673862 0.635258385137634 TUBB/TUBB4B/CADM1 3 GO:0051926 negative regulation of calcium ion transport 3/436 68/18722 0.210917138673862 0.635258385137634 CALM2/VDAC1/GSTO1 3 GO:0061912 selective autophagy 3/436 68/18722 0.210917138673862 0.635258385137634 SLC25A5/VDAC1/PHB2 3 GO:0043401 steroid hormone mediated signaling pathway 5/436 136/18722 0.211259054923358 0.635258385137634 BRCA1/YWHAH/PARP1/PTGES3/PHB2 5 GO:0043624 cellular protein complex disassembly 5/436 136/18722 0.211259054923358 0.635258385137634 STMN1/TPX2/CKAP2/HSPA8/RDX 5 GO:1900180 regulation of protein localization to nucleus 5/436 136/18722 0.211259054923358 0.635258385137634 CDK1/NUP62/PARP1/RAN/CCT5 5 GO:0033120 positive regulation of RNA splicing 2/436 37/18722 0.212847320647937 0.636131669985255 HSPA8/RBMX 2 GO:0034260 negative regulation of GTPase activity 2/436 37/18722 0.212847320647937 0.636131669985255 HRAS/RDX 2 GO:0042178 xenobiotic catabolic process 2/436 37/18722 0.212847320647937 0.636131669985255 NUDT15/GSTO1 2 GO:0043029 T cell homeostasis 2/436 37/18722 0.212847320647937 0.636131669985255 CCNB2/BAX 2 GO:0045730 respiratory burst 2/436 37/18722 0.212847320647937 0.636131669985255 PRDX2/PGAM1 2 GO:0051567 histone H3-K9 methylation 2/436 37/18722 0.212847320647937 0.636131669985255 BRCA1/RIF1 2 GO:0062237 protein localization to postsynapse 2/436 37/18722 0.212847320647937 0.636131669985255 NSG1/HRAS 2 GO:1904063 negative regulation of cation transmembrane transport 4/436 102/18722 0.214228669758308 0.637063548356403 CALM2/PPIF/VDAC1/GSTO1 4 GO:0006986 response to unfolded protein 5/436 137/18722 0.215430259368922 0.637063548356403 HSP90AA1/HSPA8/CCND1/BAX/HSPD1 5 GO:0009145 purine nucleoside triphosphate biosynthetic process 3/436 69/18722 0.216998930612657 0.637063548356403 PARP1/ENO1/NME1 3 GO:0050688 regulation of defense response to virus 3/436 69/18722 0.216998930612657 0.637063548356403 HERC5/HSP90AA1/C1QBP 3 GO:1901224 positive regulation of NIK/NF-kappaB signaling 3/436 69/18722 0.216998930612657 0.637063548356403 HMGB1/RPS3/PHB2 3 GO:0045639 positive regulation of myeloid cell differentiation 4/436 103/18722 0.219136091438784 0.637063548356403 HMGB2/HMGB1/PRKDC/JUN 4 GO:0019724 B cell mediated immunity 7/436 210/18722 0.219180779251679 0.637063548356403 UNG/MSH2/MSH6/CD81/RIF1/C1QBP/HSPD1 7 GO:0031098 stress-activated protein kinase signaling cascade 8/436 247/18722 0.219594240625912 0.637063548356403 PBK/HMGB1/FOXM1/HACD3/PPIA/GSTP1/MARVELD3/HRAS 8 GO:0036293 response to decreased oxygen levels 10/436 322/18722 0.219882689544768 0.637063548356403 CCNA2/SLC29A1/EIF4EBP1/ENO1/CHCHD2/HILPDA/PDLIM1/LDHA/HSPD1/PHB2 10 GO:0006882 cellular zinc ion homeostasis 2/436 38/18722 0.221445613052028 0.637063548356403 MT2A/SLC39A10 2 GO:0010613 positive regulation of cardiac muscle hypertrophy 2/436 38/18722 0.221445613052028 0.637063548356403 PARP1/PARP2 2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2/436 38/18722 0.221445613052028 0.637063548356403 BRCA1/PHB2 2 GO:0035337 fatty-acyl-CoA metabolic process 2/436 38/18722 0.221445613052028 0.637063548356403 NUDT8/SLC25A1 2 GO:0046329 negative regulation of JNK cascade 2/436 38/18722 0.221445613052028 0.637063548356403 GSTP1/MARVELD3 2 GO:0048246 macrophage chemotaxis 2/436 38/18722 0.221445613052028 0.637063548356403 CKLF/DDT 2 GO:0071392 cellular response to estradiol stimulus 2/436 38/18722 0.221445613052028 0.637063548356403 CCNA2/HNRNPD 2 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 2/436 38/18722 0.221445613052028 0.637063548356403 SLC25A5/BAX 2 GO:0052126 movement in host environment 6/436 175/18722 0.2242984570257 0.637063548356403 CDK1/SIVA1/PPIA/LY6E/CD81/DYNLT1 6 GO:0031333 negative regulation of protein-containing complex assembly 5/436 140/18722 0.228095650048037 0.637063548356403 STMN1/HMGB1/EIF4EBP1/SVIP/RDX 5 GO:0046165 alcohol biosynthetic process 5/436 140/18722 0.228095650048037 0.637063548356403 DHFR/PGP/IMPA2/FDPS/DHCR24 5 GO:0002443 leukocyte mediated immunity 13/436 440/18722 0.228202547039503 0.637063548356403 UNG/HMGB1/TUBB/MSH2/MSH6/TUBB4B/EMP2/CADM1/CD81/RIF1/C1QBP/HSPD1/CTSH 13 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/436 11/18722 0.228384775423601 0.637063548356403 TSEN34 1 GO:0001765 membrane raft assembly 1/436 11/18722 0.228384775423601 0.637063548356403 EMP2 1 GO:0002357 defense response to tumor cell 1/436 11/18722 0.228384775423601 0.637063548356403 PRDX2 1 GO:0003093 regulation of glomerular filtration 1/436 11/18722 0.228384775423601 0.637063548356403 EMP2 1 GO:0006020 inositol metabolic process 1/436 11/18722 0.228384775423601 0.637063548356403 IMPA2 1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/436 11/18722 0.228384775423601 0.637063548356403 MPC2 1 GO:0006183 GTP biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 NME1 1 GO:0006188 IMP biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 PAICS 1 GO:0008611 ether lipid biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 CHPT1 1 GO:0009128 purine nucleoside monophosphate catabolic process 1/436 11/18722 0.228384775423601 0.637063548356403 DNPH1 1 GO:0010269 response to selenium ion 1/436 11/18722 0.228384775423601 0.637063548356403 GPX1 1 GO:0019048 modulation by virus of host process 1/436 11/18722 0.228384775423601 0.637063548356403 PHB2 1 GO:0019372 lipoxygenase pathway 1/436 11/18722 0.228384775423601 0.637063548356403 GPX1 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/436 11/18722 0.228384775423601 0.637063548356403 PARP1 1 GO:0033327 Leydig cell differentiation 1/436 11/18722 0.228384775423601 0.637063548356403 CCND1 1 GO:0033483 gas homeostasis 1/436 11/18722 0.228384775423601 0.637063548356403 GSTP1 1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1/436 11/18722 0.228384775423601 0.637063548356403 ETFB 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/436 11/18722 0.228384775423601 0.637063548356403 HMGB1 1 GO:0034770 histone H4-K20 methylation 1/436 11/18722 0.228384775423601 0.637063548356403 BRCA1 1 GO:0034975 protein folding in endoplasmic reticulum 1/436 11/18722 0.228384775423601 0.637063548356403 PDIA3 1 GO:0039530 MDA-5 signaling pathway 1/436 11/18722 0.228384775423601 0.637063548356403 C1QBP 1 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/436 11/18722 0.228384775423601 0.637063548356403 C1QBP 1 GO:0042451 purine nucleoside biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 MTAP 1 GO:0042455 ribonucleoside biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 MTAP 1 GO:0044068 modulation by symbiont of host cellular process 1/436 11/18722 0.228384775423601 0.637063548356403 PHB2 1 GO:0045161 neuronal ion channel clustering 1/436 11/18722 0.228384775423601 0.637063548356403 CNTNAP2 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/436 11/18722 0.228384775423601 0.637063548356403 HMGB2 1 GO:0045657 positive regulation of monocyte differentiation 1/436 11/18722 0.228384775423601 0.637063548356403 JUN 1 GO:0045793 positive regulation of cell size 1/436 11/18722 0.228384775423601 0.637063548356403 CDK4 1 GO:0046129 purine ribonucleoside biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 MTAP 1 GO:0046504 glycerol ether biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 CHPT1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/436 11/18722 0.228384775423601 0.637063548356403 PNKD 1 GO:0046940 nucleoside monophosphate phosphorylation 1/436 11/18722 0.228384775423601 0.637063548356403 DTYMK 1 GO:0051081 nuclear membrane disassembly 1/436 11/18722 0.228384775423601 0.637063548356403 VRK1 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/436 11/18722 0.228384775423601 0.637063548356403 BRCA1 1 GO:0051657 maintenance of organelle location 1/436 11/18722 0.228384775423601 0.637063548356403 ASPM 1 GO:0055015 ventricular cardiac muscle cell development 1/436 11/18722 0.228384775423601 0.637063548356403 CDK1 1 GO:0061635 regulation of protein complex stability 1/436 11/18722 0.228384775423601 0.637063548356403 HSPA8 1 GO:0070203 regulation of establishment of protein localization to telomere 1/436 11/18722 0.228384775423601 0.637063548356403 CCT5 1 GO:0070314 G1 to G0 transition 1/436 11/18722 0.228384775423601 0.637063548356403 EZH2 1 GO:0070341 fat cell proliferation 1/436 11/18722 0.228384775423601 0.637063548356403 TFDP1 1 GO:0070344 regulation of fat cell proliferation 1/436 11/18722 0.228384775423601 0.637063548356403 TFDP1 1 GO:0071888 macrophage apoptotic process 1/436 11/18722 0.228384775423601 0.637063548356403 CDKN2A 1 GO:0075733 intracellular transport of virus 1/436 11/18722 0.228384775423601 0.637063548356403 DYNLT1 1 GO:0090657 telomeric loop disassembly 1/436 11/18722 0.228384775423601 0.637063548356403 BLM 1 GO:0097384 cellular lipid biosynthetic process 1/436 11/18722 0.228384775423601 0.637063548356403 CHPT1 1 GO:0140042 lipid droplet formation 1/436 11/18722 0.228384775423601 0.637063548356403 SQLE 1 GO:1900222 negative regulation of amyloid-beta clearance 1/436 11/18722 0.228384775423601 0.637063548356403 LRPAP1 1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1/436 11/18722 0.228384775423601 0.637063548356403 CALM2 1 GO:1902065 response to L-glutamate 1/436 11/18722 0.228384775423601 0.637063548356403 PCNA 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/436 11/18722 0.228384775423601 0.637063548356403 BAX 1 GO:1902510 regulation of apoptotic DNA fragmentation 1/436 11/18722 0.228384775423601 0.637063548356403 BAX 1 GO:1902915 negative regulation of protein polyubiquitination 1/436 11/18722 0.228384775423601 0.637063548356403 PPIA 1 GO:1904181 positive regulation of membrane depolarization 1/436 11/18722 0.228384775423601 0.637063548356403 PARP1 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/436 11/18722 0.228384775423601 0.637063548356403 IDH2 1 GO:1904869 regulation of protein localization to Cajal body 1/436 11/18722 0.228384775423601 0.637063548356403 CCT5 1 GO:1904871 positive regulation of protein localization to Cajal body 1/436 11/18722 0.228384775423601 0.637063548356403 CCT5 1 GO:1905522 negative regulation of macrophage migration 1/436 11/18722 0.228384775423601 0.637063548356403 DDT 1 GO:1905668 positive regulation of protein localization to endosome 1/436 11/18722 0.228384775423601 0.637063548356403 RDX 1 GO:1990773 matrix metallopeptidase secretion 1/436 11/18722 0.228384775423601 0.637063548356403 IDH2 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/436 11/18722 0.228384775423601 0.637063548356403 HMGB1 1 GO:0032231 regulation of actin filament bundle assembly 4/436 105/18722 0.229039511441367 0.637620501288848 STMN1/ID1/TACSTD2/RDX 4 GO:0002228 natural killer cell mediated immunity 3/436 71/18722 0.229268555757533 0.637620501288848 TUBB/TUBB4B/CADM1 3 GO:0014742 positive regulation of muscle hypertrophy 2/436 39/18722 0.230071168929057 0.637620501288848 PARP1/PARP2 2 GO:0031507 heterochromatin assembly 2/436 39/18722 0.230071168929057 0.637620501288848 HELLS/POLE3 2 GO:0051154 negative regulation of striated muscle cell differentiation 2/436 39/18722 0.230071168929057 0.637620501288848 EZH2/YBX1 2 GO:0090224 regulation of spindle organization 2/436 39/18722 0.230071168929057 0.637620501288848 TPX2/NUP62 2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 2/436 39/18722 0.230071168929057 0.637620501288848 CALM2/GSTO1 2 GO:1902742 apoptotic process involved in development 2/436 39/18722 0.230071168929057 0.637620501288848 CHEK1/BAX 2 GO:0030324 lung development 6/436 177/18722 0.231838960138153 0.638074255697051 HMGB1/EIF4EBP1/HSPB11/DPPA4/PTGES3/CTSH 6 GO:0043405 regulation of MAP kinase activity 6/436 177/18722 0.231838960138153 0.638074255697051 EZH2/NUP62/GSTP1/HRAS/RPS3/ERP29 6 GO:0030183 B cell differentiation 5/436 141/18722 0.232365480040877 0.638074255697051 MSH2/EZH2/PRKDC/SLC25A5/BAX 5 GO:0044242 cellular lipid catabolic process 7/436 214/18722 0.232787495780788 0.638074255697051 ACAT2/NUDT8/HADH/SLC27A2/ECI1/ETFB/ECHS1 7 GO:0006766 vitamin metabolic process 4/436 106/18722 0.234033001355983 0.638074255697051 DHFR/MTHFD2/VKORC1/GSTO1 4 GO:0071887 leukocyte apoptotic process 4/436 106/18722 0.234033001355983 0.638074255697051 AURKB/CDKN2A/BAX/SLC39A10 4 GO:0042246 tissue regeneration 3/436 72/18722 0.235451589535673 0.638074255697051 EZH2/CD81/GPX1 3 GO:0042273 ribosomal large subunit biogenesis 3/436 72/18722 0.235451589535673 0.638074255697051 RPL35/RPL3/RPL7A 3 GO:0050709 negative regulation of protein secretion 3/436 72/18722 0.235451589535673 0.638074255697051 HADH/IDH2/ERP29 3 GO:0070227 lymphocyte apoptotic process 3/436 72/18722 0.235451589535673 0.638074255697051 AURKB/BAX/SLC39A10 3 GO:1901880 negative regulation of protein depolymerization 3/436 72/18722 0.235451589535673 0.638074255697051 TPX2/CKAP2/RDX 3 GO:1903036 positive regulation of response to wounding 3/436 72/18722 0.235451589535673 0.638074255697051 HMGB1/PRDX2/HRAS 3 GO:0009615 response to virus 11/436 367/18722 0.238249573240485 0.638074255697051 STMN1/HERC5/POLR3K/HSP90AA1/ENO1/HMGA1/ILF3/BAX/CCT5/C1QBP/PHB2 11 GO:0002714 positive regulation of B cell mediated immunity 2/436 40/18722 0.238718071402732 0.638074255697051 MSH2/RIF1 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/436 40/18722 0.238718071402732 0.638074255697051 MSH2/RIF1 2 GO:0009069 serine family amino acid metabolic process 2/436 40/18722 0.238718071402732 0.638074255697051 DHFR/GCSH 2 GO:0010863 positive regulation of phospholipase C activity 2/436 40/18722 0.238718071402732 0.638074255697051 HRAS/PHB2 2 GO:0045022 early endosome to late endosome transport 2/436 40/18722 0.238718071402732 0.638074255697051 EMP2/RDX 2 GO:0055069 zinc ion homeostasis 2/436 40/18722 0.238718071402732 0.638074255697051 MT2A/SLC39A10 2 GO:0071276 cellular response to cadmium ion 2/436 40/18722 0.238718071402732 0.638074255697051 MT2A/JUN 2 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 2/436 40/18722 0.238718071402732 0.638074255697051 CALM2/GSTO1 2 GO:1901661 quinone metabolic process 2/436 40/18722 0.238718071402732 0.638074255697051 AKR7A2/VKORC1 2 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/436 107/18722 0.239052679482525 0.638074255697051 MSH2/CD81/RIF1/HSPD1 4 GO:0021761 limbic system development 4/436 107/18722 0.239052679482525 0.638074255697051 EZH2/CNTNAP2/NME1/BAX 4 GO:1904427 positive regulation of calcium ion transmembrane transport 3/436 73/18722 0.241663627449284 0.638074255697051 CALM2/BAX/GSTO1 3 GO:0010821 regulation of mitochondrion organization 5/436 144/18722 0.245308281064563 0.638074255697051 SLC25A5/PPIF/BAX/VDAC1/GPX1 5 GO:0046718 viral entry into host cell 5/436 144/18722 0.245308281064563 0.638074255697051 CDK1/SIVA1/LY6E/CD81/DYNLT1 5 GO:0000012 single strand break repair 1/436 12/18722 0.246364799896655 0.638074255697051 PARP1 1 GO:0002328 pro-B cell differentiation 1/436 12/18722 0.246364799896655 0.638074255697051 PRKDC 1 GO:0002674 negative regulation of acute inflammatory response 1/436 12/18722 0.246364799896655 0.638074255697051 GSTP1 1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/436 12/18722 0.246364799896655 0.638074255697051 CD81 1 GO:0006285 base-excision repair, AP site formation 1/436 12/18722 0.246364799896655 0.638074255697051 UNG 1 GO:0009086 methionine biosynthetic process 1/436 12/18722 0.246364799896655 0.638074255697051 MTAP 1 GO:0010826 negative regulation of centrosome duplication 1/436 12/18722 0.246364799896655 0.638074255697051 BRCA1 1 GO:0030397 membrane disassembly 1/436 12/18722 0.246364799896655 0.638074255697051 VRK1 1 GO:0031223 auditory behavior 1/436 12/18722 0.246364799896655 0.638074255697051 CNTNAP2 1 GO:0032780 negative regulation of ATPase activity 1/436 12/18722 0.246364799896655 0.638074255697051 PPIF 1 GO:0033235 positive regulation of protein sumoylation 1/436 12/18722 0.246364799896655 0.638074255697051 SAE1 1 GO:0034086 maintenance of sister chromatid cohesion 1/436 12/18722 0.246364799896655 0.638074255697051 DSCC1 1 GO:0034088 maintenance of mitotic sister chromatid cohesion 1/436 12/18722 0.246364799896655 0.638074255697051 DSCC1 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/436 12/18722 0.246364799896655 0.638074255697051 HMGB1 1 GO:0035092 sperm chromatin condensation 1/436 12/18722 0.246364799896655 0.638074255697051 SRPK1 1 GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/436 12/18722 0.246364799896655 0.638074255697051 CD81 1 GO:0042118 endothelial cell activation 1/436 12/18722 0.246364799896655 0.638074255697051 PPIA 1 GO:0043129 surfactant homeostasis 1/436 12/18722 0.246364799896655 0.638074255697051 CTSH 1 GO:0043248 proteasome assembly 1/436 12/18722 0.246364799896655 0.638074255697051 PSMG1 1 GO:0043696 dedifferentiation 1/436 12/18722 0.246364799896655 0.638074255697051 HNRNPD 1 GO:0043697 cell dedifferentiation 1/436 12/18722 0.246364799896655 0.638074255697051 HNRNPD 1 GO:0044650 adhesion of symbiont to host cell 1/436 12/18722 0.246364799896655 0.638074255697051 CD81 1 GO:0045602 negative regulation of endothelial cell differentiation 1/436 12/18722 0.246364799896655 0.638074255697051 ID1 1 GO:0045605 negative regulation of epidermal cell differentiation 1/436 12/18722 0.246364799896655 0.638074255697051 EZH2 1 GO:0045683 negative regulation of epidermis development 1/436 12/18722 0.246364799896655 0.638074255697051 EZH2 1 GO:0046051 UTP metabolic process 1/436 12/18722 0.246364799896655 0.638074255697051 NME1 1 GO:0046185 aldehyde catabolic process 1/436 12/18722 0.246364799896655 0.638074255697051 PNKD 1 GO:0046606 negative regulation of centrosome cycle 1/436 12/18722 0.246364799896655 0.638074255697051 BRCA1 1 GO:0046831 regulation of RNA export from nucleus 1/436 12/18722 0.246364799896655 0.638074255697051 KHDRBS1 1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/436 12/18722 0.246364799896655 0.638074255697051 PARP2 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/436 12/18722 0.246364799896655 0.638074255697051 ENO1 1 GO:0070202 regulation of establishment of protein localization to chromosome 1/436 12/18722 0.246364799896655 0.638074255697051 CCT5 1 GO:0070493 thrombin-activated receptor signaling pathway 1/436 12/18722 0.246364799896655 0.638074255697051 STMN1 1 GO:0071712 ER-associated misfolded protein catabolic process 1/436 12/18722 0.246364799896655 0.638074255697051 SDF2L1 1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/436 12/18722 0.246364799896655 0.638074255697051 JUN 1 GO:1901503 ether biosynthetic process 1/436 12/18722 0.246364799896655 0.638074255697051 CHPT1 1 GO:1903405 protein localization to nuclear body 1/436 12/18722 0.246364799896655 0.638074255697051 CCT5 1 GO:1903624 regulation of DNA catabolic process 1/436 12/18722 0.246364799896655 0.638074255697051 BAX 1 GO:1903909 regulation of receptor clustering 1/436 12/18722 0.246364799896655 0.638074255697051 CD81 1 GO:1904748 regulation of apoptotic process involved in development 1/436 12/18722 0.246364799896655 0.638074255697051 BAX 1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 1/436 12/18722 0.246364799896655 0.638074255697051 CCT5 1 GO:1904867 protein localization to Cajal body 1/436 12/18722 0.246364799896655 0.638074255697051 CCT5 1 GO:1905214 regulation of RNA binding 1/436 12/18722 0.246364799896655 0.638074255697051 NUCKS1 1 GO:1905666 regulation of protein localization to endosome 1/436 12/18722 0.246364799896655 0.638074255697051 RDX 1 GO:1905709 negative regulation of membrane permeability 1/436 12/18722 0.246364799896655 0.638074255697051 DYNLT1 1 GO:1990034 calcium ion export across plasma membrane 1/436 12/18722 0.246364799896655 0.638074255697051 CALM2 1 GO:2000508 regulation of dendritic cell chemotaxis 1/436 12/18722 0.246364799896655 0.638074255697051 C1QBP 1 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/436 12/18722 0.246364799896655 0.638074255697051 CD81 1 GO:2000628 regulation of miRNA metabolic process 1/436 12/18722 0.246364799896655 0.638074255697051 HRAS 1 GO:0045088 regulation of innate immune response 7/436 218/18722 0.246668345334887 0.638074255697051 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/XRCC5/XRCC6 7 GO:0006479 protein methylation 6/436 181/18722 0.247152042258923 0.638074255697051 BRCA1/EZH2/SNRPB/SUZ12/RIF1/SNRPD3 6 GO:0008213 protein alkylation 6/436 181/18722 0.247152042258923 0.638074255697051 BRCA1/EZH2/SNRPB/SUZ12/RIF1/SNRPD3 6 GO:0030323 respiratory tube development 6/436 181/18722 0.247152042258923 0.638074255697051 HMGB1/EIF4EBP1/HSPB11/DPPA4/PTGES3/CTSH 6 GO:0009167 purine ribonucleoside monophosphate metabolic process 2/436 41/18722 0.247380663193522 0.638074255697051 GMPS/PAICS 2 GO:0031062 positive regulation of histone methylation 2/436 41/18722 0.247380663193522 0.638074255697051 BRCA1/RIF1 2 GO:0032733 positive regulation of interleukin-10 production 2/436 41/18722 0.247380663193522 0.638074255697051 HMGB1/HSPD1 2 GO:0032735 positive regulation of interleukin-12 production 2/436 41/18722 0.247380663193522 0.638074255697051 HMGB1/HSPD1 2 GO:0042307 positive regulation of protein import into nucleus 2/436 41/18722 0.247380663193522 0.638074255697051 CDK1/RAN 2 GO:0050856 regulation of T cell receptor signaling pathway 2/436 41/18722 0.247380663193522 0.638074255697051 CD81/RPS3 2 GO:0055023 positive regulation of cardiac muscle tissue growth 2/436 41/18722 0.247380663193522 0.638074255697051 CDK1/PARP2 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/436 41/18722 0.247380663193522 0.638074255697051 CALM2/GSTO1 2 GO:0071470 cellular response to osmotic stress 2/436 41/18722 0.247380663193522 0.638074255697051 XRCC5/XRCC6 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/436 41/18722 0.247380663193522 0.638074255697051 PARP1/ENO1 2 GO:1905521 regulation of macrophage migration 2/436 41/18722 0.247380663193522 0.638074255697051 DDT/CD81 2 GO:0006801 superoxide metabolic process 3/436 74/18722 0.247902355827505 0.638074255697051 DHFR/PRDX2/GSTP1 3 GO:0009201 ribonucleoside triphosphate biosynthetic process 3/436 74/18722 0.247902355827505 0.638074255697051 PARP1/ENO1/NME1 3 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 3/436 74/18722 0.247902355827505 0.638074255697051 BRCA1/PARP1/PHB2 3 GO:1903201 regulation of oxidative stress-induced cell death 3/436 74/18722 0.247902355827505 0.638074255697051 PARP1/PPIA/GPX1 3 GO:0032414 positive regulation of ion transmembrane transporter activity 4/436 109/18722 0.24916563730608 0.640365019922967 CALM2/ATP1B3/GSTO1/NDUFA4 4 GO:0034766 negative regulation of ion transmembrane transport 4/436 109/18722 0.24916563730608 0.640365019922967 CALM2/PPIF/VDAC1/GSTO1 4 GO:0043524 negative regulation of neuron apoptotic process 5/436 145/18722 0.249664412090649 0.641166615181899 MSH2/SET/HRAS/BAX/HSPD1 5 GO:0031503 protein-containing complex localization 7/436 220/18722 0.25370386720677 0.648318260063629 BIRC5/RAN/NSG1/HSPB11/HNRNPA2B1/HRAS/SRSF3 7 GO:0006094 gluconeogenesis 3/436 75/18722 0.25416549721911 0.648318260063629 PGP/SLC25A1/TPI1 3 GO:1902369 negative regulation of RNA catabolic process 3/436 75/18722 0.25416549721911 0.648318260063629 FUS/HNRNPD/YBX1 3 GO:1903363 negative regulation of cellular protein catabolic process 3/436 75/18722 0.25416549721911 0.648318260063629 PBK/SVIP/RPS7 3 GO:0009154 purine ribonucleotide catabolic process 2/436 42/18722 0.25605353778357 0.648318260063629 NUDT8/HINT1 2 GO:0016601 Rac protein signal transduction 2/436 42/18722 0.25605353778357 0.648318260063629 HACD3/DYNLT1 2 GO:0030808 regulation of nucleotide biosynthetic process 2/436 42/18722 0.25605353778357 0.648318260063629 PARP1/ENO1 2 GO:0030890 positive regulation of B cell proliferation 2/436 42/18722 0.25605353778357 0.648318260063629 CD81/SLC39A10 2 GO:0032689 negative regulation of interferon-gamma production 2/436 42/18722 0.25605353778357 0.648318260063629 HMGB1/C1QBP 2 GO:0045292 mRNA cis splicing, via spliceosome 2/436 42/18722 0.25605353778357 0.648318260063629 PSIP1/RBM17 2 GO:0046688 response to copper ion 2/436 42/18722 0.25605353778357 0.648318260063629 CDK1/MT2A 2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 2/436 42/18722 0.25605353778357 0.648318260063629 EXOSC9/EXOSC8 2 GO:1900274 regulation of phospholipase C activity 2/436 42/18722 0.25605353778357 0.648318260063629 HRAS/PHB2 2 GO:0006805 xenobiotic metabolic process 4/436 111/18722 0.259368523410555 0.648318260063629 VKORC1/NUDT15/GSTP1/GSTO1 4 GO:0071426 ribonucleoprotein complex export from nucleus 3/436 76/18722 0.260450811245901 0.648318260063629 RAN/HNRNPA2B1/SRSF3 3 GO:0043433 negative regulation of DNA-binding transcription factor activity 6/436 185/18722 0.262746332101813 0.648318260063629 EZH2/ID1/ID3/CDKN2A/PRDX2/PHB2 6 GO:0002638 negative regulation of immunoglobulin production 1/436 13/18722 0.263926796008096 0.648318260063629 PRKDC 1 GO:0005513 detection of calcium ion 1/436 13/18722 0.263926796008096 0.648318260063629 CALM2 1 GO:0007183 SMAD protein complex assembly 1/436 13/18722 0.263926796008096 0.648318260063629 PARP1 1 GO:0010755 regulation of plasminogen activation 1/436 13/18722 0.263926796008096 0.648318260063629 ENO1 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/436 13/18722 0.263926796008096 0.648318260063629 BAX 1 GO:0014029 neural crest formation 1/436 13/18722 0.263926796008096 0.648318260063629 TCOF1 1 GO:0021794 thalamus development 1/436 13/18722 0.263926796008096 0.648318260063629 CNTNAP2 1 GO:0030497 fatty acid elongation 1/436 13/18722 0.263926796008096 0.648318260063629 HACD3 1 GO:0031053 primary miRNA processing 1/436 13/18722 0.263926796008096 0.648318260063629 HNRNPA2B1 1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 1/436 13/18722 0.263926796008096 0.648318260063629 PRDX2 1 GO:0032042 mitochondrial DNA metabolic process 1/436 13/18722 0.263926796008096 0.648318260063629 PARP1 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/436 13/18722 0.263926796008096 0.648318260063629 ZDHHC12 1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 1/436 13/18722 0.263926796008096 0.648318260063629 SUPT16H 1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1/436 13/18722 0.263926796008096 0.648318260063629 PARP1 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/436 13/18722 0.263926796008096 0.648318260063629 HMGB1 1 GO:0035745 T-helper 2 cell cytokine production 1/436 13/18722 0.263926796008096 0.648318260063629 CD81 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/436 13/18722 0.263926796008096 0.648318260063629 HACD3 1 GO:0043247 telomere maintenance in response to DNA damage 1/436 13/18722 0.263926796008096 0.648318260063629 RIF1 1 GO:0048012 hepatocyte growth factor receptor signaling pathway 1/436 13/18722 0.263926796008096 0.648318260063629 STMN1 1 GO:0048070 regulation of developmental pigmentation 1/436 13/18722 0.263926796008096 0.648318260063629 BAX 1 GO:0048266 behavioral response to pain 1/436 13/18722 0.263926796008096 0.648318260063629 VWA1 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/436 13/18722 0.263926796008096 0.648318260063629 MSH2 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/436 13/18722 0.263926796008096 0.648318260063629 AURKB 1 GO:0060670 branching involved in labyrinthine layer morphogenesis 1/436 13/18722 0.263926796008096 0.648318260063629 SPINT2 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/436 13/18722 0.263926796008096 0.648318260063629 ENO1 1 GO:0061744 motor behavior 1/436 13/18722 0.263926796008096 0.648318260063629 C12orf57 1 GO:0070316 regulation of G0 to G1 transition 1/436 13/18722 0.263926796008096 0.648318260063629 CHEK1 1 GO:0070914 UV-damage excision repair 1/436 13/18722 0.263926796008096 0.648318260063629 POLD3 1 GO:0098814 spontaneous synaptic transmission 1/436 13/18722 0.263926796008096 0.648318260063629 NSG1 1 GO:0120305 regulation of pigmentation 1/436 13/18722 0.263926796008096 0.648318260063629 BAX 1 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 1/436 13/18722 0.263926796008096 0.648318260063629 BAX 1 GO:1900115 extracellular regulation of signal transduction 1/436 13/18722 0.263926796008096 0.648318260063629 LRPAP1 1 GO:1900116 extracellular negative regulation of signal transduction 1/436 13/18722 0.263926796008096 0.648318260063629 LRPAP1 1 GO:1902947 regulation of tau-protein kinase activity 1/436 13/18722 0.263926796008096 0.648318260063629 HSP90AA1 1 GO:1903651 positive regulation of cytoplasmic transport 1/436 13/18722 0.263926796008096 0.648318260063629 RDX 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/436 13/18722 0.263926796008096 0.648318260063629 CD81 1 GO:2001198 regulation of dendritic cell differentiation 1/436 13/18722 0.263926796008096 0.648318260063629 HMGB1 1 GO:0000956 nuclear-transcribed mRNA catabolic process 4/436 112/18722 0.264500639543946 0.648318260063629 EXOSC9/LSM4/EXOSC8/MAGOHB 4 GO:0001676 long-chain fatty acid metabolic process 4/436 112/18722 0.264500639543946 0.648318260063629 SLC27A2/GSTP1/PTGES3/GPX1 4 GO:0002821 positive regulation of adaptive immune response 4/436 112/18722 0.264500639543946 0.648318260063629 MSH2/CD81/RIF1/HSPD1 4 GO:0032609 interferon-gamma production 4/436 112/18722 0.264500639543946 0.648318260063629 HMGB1/HRAS/C1QBP/HSPD1 4 GO:0032649 regulation of interferon-gamma production 4/436 112/18722 0.264500639543946 0.648318260063629 HMGB1/HRAS/C1QBP/HSPD1 4 GO:0043406 positive regulation of MAP kinase activity 4/436 112/18722 0.264500639543946 0.648318260063629 EZH2/HRAS/RPS3/ERP29 4 GO:0002861 regulation of inflammatory response to antigenic stimulus 2/436 43/18722 0.264731530850814 0.648318260063629 CD81/GPX1 2 GO:0034661 ncRNA catabolic process 2/436 43/18722 0.264731530850814 0.648318260063629 EXOSC9/EXOSC8 2 GO:0042088 T-helper 1 type immune response 2/436 43/18722 0.264731530850814 0.648318260063629 HMGB1/HRAS 2 GO:0060443 mammary gland morphogenesis 2/436 43/18722 0.264731530850814 0.648318260063629 BAX/PHB2 2 GO:0098927 vesicle-mediated transport between endosomal compartments 2/436 43/18722 0.264731530850814 0.648318260063629 EMP2/RDX 2 GO:1904591 positive regulation of protein import 2/436 43/18722 0.264731530850814 0.648318260063629 CDK1/RAN 2 GO:0006367 transcription initiation from RNA polymerase II promoter 3/436 77/18722 0.266756095367498 0.652345091379819 HMGB1/CDK4/POLR2I 3 GO:0071166 ribonucleoprotein complex localization 3/436 77/18722 0.266756095367498 0.652345091379819 RAN/HNRNPA2B1/SRSF3 3 GO:0016485 protein processing 7/436 225/18722 0.271544920445408 0.657491891910482 DHCR24/PARP1/BCL2L12/ENO1/SEC11A/PERP/CTSH 7 GO:0019319 hexose biosynthetic process 3/436 78/18722 0.273079185561856 0.657491891910482 PGP/SLC25A1/TPI1 3 GO:0034637 cellular carbohydrate biosynthetic process 3/436 78/18722 0.273079185561856 0.657491891910482 PGP/IMPA2/PTGES3 3 GO:0021762 substantia nigra development 2/436 44/18722 0.273409711964581 0.657491891910482 YWHAH/CALM2 2 GO:0046006 regulation of activated T cell proliferation 2/436 44/18722 0.273409711964581 0.657491891910482 HMGB1/RPS3 2 GO:0048806 genitalia development 2/436 44/18722 0.273409711964581 0.657491891910482 DHCR24/BAX 2 GO:1903214 regulation of protein targeting to mitochondrion 2/436 44/18722 0.273409711964581 0.657491891910482 SAE1/LMAN1 2 GO:0032868 response to insulin 8/436 264/18722 0.27432695124656 0.657491891910482 HADH/PRKDC/PARP1/CDK4/NUCKS1/GGH/GSTP1/SNX5 8 GO:0001906 cell killing 6/436 188/18722 0.274606072639207 0.657491891910482 TUBB/HMGN2/TUBB4B/EMP2/CADM1/CTSH 6 GO:0019751 polyol metabolic process 4/436 114/18722 0.274820191006961 0.657491891910482 DHFR/PGP/IMPA2/TPI1 4 GO:0044409 entry into host 5/436 151/18722 0.276186820392313 0.657491891910482 CDK1/SIVA1/LY6E/CD81/DYNLT1 5 GO:0048592 eye morphogenesis 5/436 151/18722 0.276186820392313 0.657491891910482 FAT1/HMGN1/BAX/C12orf57/EFEMP1 5 GO:0001933 negative regulation of protein phosphorylation 10/436 342/18722 0.27623890249395 0.657491891910482 PBK/CALM2/PRKDC/NUP62/PPIA/CDKN2A/GSTP1/SUZ12/CTDSPL/BAX 10 GO:0046578 regulation of Ras protein signal transduction 6/436 189/18722 0.278587711030559 0.657491891910482 STMN1/FOXM1/NUP62/HRAS/DYNLT1/RDX 6 GO:0051279 regulation of release of sequestered calcium ion into cytosol 3/436 79/18722 0.279417956925647 0.657491891910482 CALM2/BAX/GSTO1 3 GO:0034968 histone lysine methylation 4/436 115/18722 0.280005243349417 0.657491891910482 BRCA1/EZH2/SUZ12/RIF1 4 GO:0043279 response to alkaloid 4/436 115/18722 0.280005243349417 0.657491891910482 RAD51/BLM/CCNA2/HSPD1 4 GO:0000054 ribosomal subunit export from nucleus 1/436 14/18722 0.281080460925541 0.657491891910482 RAN 1 GO:0001771 immunological synapse formation 1/436 14/18722 0.281080460925541 0.657491891910482 CD81 1 GO:0001921 positive regulation of receptor recycling 1/436 14/18722 0.281080460925541 0.657491891910482 NSG1 1 GO:0002091 negative regulation of receptor internalization 1/436 14/18722 0.281080460925541 0.657491891910482 LRPAP1 1 GO:0006241 CTP biosynthetic process 1/436 14/18722 0.281080460925541 0.657491891910482 NME1 1 GO:0006465 signal peptide processing 1/436 14/18722 0.281080460925541 0.657491891910482 SEC11A 1 GO:0007638 mechanosensory behavior 1/436 14/18722 0.281080460925541 0.657491891910482 CNTNAP2 1 GO:0009071 serine family amino acid catabolic process 1/436 14/18722 0.281080460925541 0.657491891910482 GCSH 1 GO:0009159 deoxyribonucleoside monophosphate catabolic process 1/436 14/18722 0.281080460925541 0.657491891910482 DNPH1 1 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 1/436 14/18722 0.281080460925541 0.657491891910482 TACSTD2 1 GO:0018158 protein oxidation 1/436 14/18722 0.281080460925541 0.657491891910482 GPX1 1 GO:0022038 corpus callosum development 1/436 14/18722 0.281080460925541 0.657491891910482 C12orf57 1 GO:0030007 cellular potassium ion homeostasis 1/436 14/18722 0.281080460925541 0.657491891910482 ATP1B3 1 GO:0031115 negative regulation of microtubule polymerization 1/436 14/18722 0.281080460925541 0.657491891910482 STMN1 1 GO:0033750 ribosome localization 1/436 14/18722 0.281080460925541 0.657491891910482 RAN 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/436 14/18722 0.281080460925541 0.657491891910482 RDX 1 GO:0035815 positive regulation of renal sodium excretion 1/436 14/18722 0.281080460925541 0.657491891910482 SNX5 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/436 14/18722 0.281080460925541 0.657491891910482 DBI 1 GO:0036444 calcium import into the mitochondrion 1/436 14/18722 0.281080460925541 0.657491891910482 VDAC1 1 GO:0042415 norepinephrine metabolic process 1/436 14/18722 0.281080460925541 0.657491891910482 LY6E 1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1/436 14/18722 0.281080460925541 0.657491891910482 EEF1E1 1 GO:0045023 G0 to G1 transition 1/436 14/18722 0.281080460925541 0.657491891910482 CHEK1 1 GO:0045837 negative regulation of membrane potential 1/436 14/18722 0.281080460925541 0.657491891910482 BAX 1 GO:0045989 positive regulation of striated muscle contraction 1/436 14/18722 0.281080460925541 0.657491891910482 GSTO1 1 GO:0048875 chemical homeostasis within a tissue 1/436 14/18722 0.281080460925541 0.657491891910482 CTSH 1 GO:0051589 negative regulation of neurotransmitter transport 1/436 14/18722 0.281080460925541 0.657491891910482 PNKD 1 GO:0055057 neuroblast division 1/436 14/18722 0.281080460925541 0.657491891910482 ASPM 1 GO:0060576 intestinal epithelial cell development 1/436 14/18722 0.281080460925541 0.657491891910482 TYMS 1 GO:0070141 response to UV-A 1/436 14/18722 0.281080460925541 0.657491891910482 CCND1 1 GO:0070986 left/right axis specification 1/436 14/18722 0.281080460925541 0.657491891910482 HSPB11 1 GO:0071236 cellular response to antibiotic 1/436 14/18722 0.281080460925541 0.657491891910482 EZH2 1 GO:0072350 tricarboxylic acid metabolic process 1/436 14/18722 0.281080460925541 0.657491891910482 IDH2 1 GO:0072531 pyrimidine-containing compound transmembrane transport 1/436 14/18722 0.281080460925541 0.657491891910482 SLC29A1 1 GO:0090239 regulation of histone H4 acetylation 1/436 14/18722 0.281080460925541 0.657491891910482 BRCA1 1 GO:0090281 negative regulation of calcium ion import 1/436 14/18722 0.281080460925541 0.657491891910482 VDAC1 1 GO:0099638 endosome to plasma membrane protein transport 1/436 14/18722 0.281080460925541 0.657491891910482 NSG1 1 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 1/436 14/18722 0.281080460925541 0.657491891910482 TACSTD2 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/436 14/18722 0.281080460925541 0.657491891910482 PRKDC 1 GO:1903894 regulation of IRE1-mediated unfolded protein response 1/436 14/18722 0.281080460925541 0.657491891910482 BAX 1 GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/436 14/18722 0.281080460925541 0.657491891910482 SVIP 1 GO:1904814 regulation of protein localization to chromosome, telomeric region 1/436 14/18722 0.281080460925541 0.657491891910482 CCT5 1 GO:1990173 protein localization to nucleoplasm 1/436 14/18722 0.281080460925541 0.657491891910482 CCT5 1 GO:2001140 positive regulation of phospholipid transport 1/436 14/18722 0.281080460925541 0.657491891910482 DBI 1 GO:2001171 positive regulation of ATP biosynthetic process 1/436 14/18722 0.281080460925541 0.657491891910482 ENO1 1 GO:0003009 skeletal muscle contraction 2/436 45/18722 0.282083376535188 0.657491891910482 C12orf57/GSTO1 2 GO:0035384 thioester biosynthetic process 2/436 45/18722 0.282083376535188 0.657491891910482 SLC25A1/MPC2 2 GO:0045933 positive regulation of muscle contraction 2/436 45/18722 0.282083376535188 0.657491891910482 ENO1/GSTO1 2 GO:0048599 oocyte development 2/436 45/18722 0.282083376535188 0.657491891910482 FBXO5/BRCA2 2 GO:0060421 positive regulation of heart growth 2/436 45/18722 0.282083376535188 0.657491891910482 CDK1/PARP2 2 GO:0071616 acyl-CoA biosynthetic process 2/436 45/18722 0.282083376535188 0.657491891910482 SLC25A1/MPC2 2 GO:1901985 positive regulation of protein acetylation 2/436 45/18722 0.282083376535188 0.657491891910482 BRCA1/BRD7 2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 2/436 45/18722 0.282083376535188 0.657491891910482 SLC25A5/BAX 2 GO:1901264 carbohydrate derivative transport 3/436 80/18722 0.285770324198511 0.665633389222737 SLC29A1/SLC25A5/SLC25A6 3 GO:0002702 positive regulation of production of molecular mediator of immune response 4/436 117/18722 0.290420019630211 0.669647595231956 MSH2/CD81/RIF1/PHB2 4 GO:1903828 negative regulation of cellular protein localization 4/436 117/18722 0.290420019630211 0.669647595231956 CDT1/BARD1/SVIP/LMAN1 4 GO:0006383 transcription by RNA polymerase III 2/436 46/18722 0.290748038010253 0.669647595231956 POLR3K/POLR2L 2 GO:0031057 negative regulation of histone modification 2/436 46/18722 0.290748038010253 0.669647595231956 BRCA1/SET 2 GO:0031648 protein destabilization 2/436 46/18722 0.290748038010253 0.669647595231956 PRKDC/CTSH 2 GO:0061462 protein localization to lysosome 2/436 46/18722 0.290748038010253 0.669647595231956 HSPA8/CD81 2 GO:0070828 heterochromatin organization 2/436 46/18722 0.290748038010253 0.669647595231956 HELLS/POLE3 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/436 46/18722 0.290748038010253 0.669647595231956 AURKB/SLC39A10 2 GO:0002440 production of molecular mediator of immune response 9/436 308/18722 0.2914219883575 0.669647595231956 UNG/MSH2/MSH6/PRKDC/CTNNBL1/CD81/RIF1/HSPD1/PHB2 9 GO:0000422 autophagy of mitochondrion 3/436 81/18722 0.292134242214988 0.669647595231956 SLC25A5/VDAC1/PHB2 3 GO:0061726 mitochondrion disassembly 3/436 81/18722 0.292134242214988 0.669647595231956 SLC25A5/VDAC1/PHB2 3 GO:1903533 regulation of protein targeting 3/436 81/18722 0.292134242214988 0.669647595231956 SAE1/HRAS/LMAN1 3 GO:0043254 regulation of protein-containing complex assembly 12/436 427/18722 0.294021353746339 0.669647595231956 CDT1/STMN1/HMGB1/PARP1/EIF4EBP1/HSP90AA1/SVIP/HSPA8/ARPC5L/RPS3/BAX/RDX 12 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/436 15/18722 0.297835267373929 0.669647595231956 RPL35 1 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/436 15/18722 0.297835267373929 0.669647595231956 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/436 15/18722 0.297835267373929 0.669647595231956 RPS21 1 GO:0002070 epithelial cell maturation 1/436 15/18722 0.297835267373929 0.669647595231956 TYMS 1 GO:0002679 respiratory burst involved in defense response 1/436 15/18722 0.297835267373929 0.669647595231956 PRDX2 1 GO:0002836 positive regulation of response to tumor cell 1/436 15/18722 0.297835267373929 0.669647595231956 HSPD1 1 GO:0002839 positive regulation of immune response to tumor cell 1/436 15/18722 0.297835267373929 0.669647595231956 HSPD1 1 GO:0006098 pentose-phosphate shunt 1/436 15/18722 0.297835267373929 0.669647595231956 PGAM1 1 GO:0006878 cellular copper ion homeostasis 1/436 15/18722 0.297835267373929 0.669647595231956 MT2A 1 GO:0009083 branched-chain amino acid catabolic process 1/436 15/18722 0.297835267373929 0.669647595231956 ECHS1 1 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 1/436 15/18722 0.297835267373929 0.669647595231956 NME1 1 GO:0010273 detoxification of copper ion 1/436 15/18722 0.297835267373929 0.669647595231956 MT2A 1 GO:0016114 terpenoid biosynthetic process 1/436 15/18722 0.297835267373929 0.669647595231956 FDPS 1 GO:0019511 peptidyl-proline hydroxylation 1/436 15/18722 0.297835267373929 0.669647595231956 PRDX4 1 GO:0023035 CD40 signaling pathway 1/436 15/18722 0.297835267373929 0.669647595231956 PHB2 1 GO:0032239 regulation of nucleobase-containing compound transport 1/436 15/18722 0.297835267373929 0.669647595231956 KHDRBS1 1 GO:0032486 Rap protein signal transduction 1/436 15/18722 0.297835267373929 0.669647595231956 RDX 1 GO:0035435 phosphate ion transmembrane transport 1/436 15/18722 0.297835267373929 0.669647595231956 SLC20A1 1 GO:0036376 sodium ion export across plasma membrane 1/436 15/18722 0.297835267373929 0.669647595231956 ATP1B3 1 GO:0042182 ketone catabolic process 1/436 15/18722 0.297835267373929 0.669647595231956 PNKD 1 GO:0042559 pteridine-containing compound biosynthetic process 1/436 15/18722 0.297835267373929 0.669647595231956 DHFR 1 GO:0043508 negative regulation of JUN kinase activity 1/436 15/18722 0.297835267373929 0.669647595231956 GSTP1 1 GO:0044406 adhesion of symbiont to host 1/436 15/18722 0.297835267373929 0.669647595231956 CD81 1 GO:0045176 apical protein localization 1/436 15/18722 0.297835267373929 0.669647595231956 RDX 1 GO:0045836 positive regulation of meiotic nuclear division 1/436 15/18722 0.297835267373929 0.669647595231956 RAD51AP1 1 GO:0046184 aldehyde biosynthetic process 1/436 15/18722 0.297835267373929 0.669647595231956 TPI1 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/436 15/18722 0.297835267373929 0.669647595231956 CDK1 1 GO:0060253 negative regulation of glial cell proliferation 1/436 15/18722 0.297835267373929 0.669647595231956 IDH2 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/436 15/18722 0.297835267373929 0.669647595231956 CD81 1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 1/436 15/18722 0.297835267373929 0.669647595231956 RAN 1 GO:0140374 antiviral innate immune response 1/436 15/18722 0.297835267373929 0.669647595231956 PHB2 1 GO:1900029 positive regulation of ruffle assembly 1/436 15/18722 0.297835267373929 0.669647595231956 HRAS 1 GO:1901660 calcium ion export 1/436 15/18722 0.297835267373929 0.669647595231956 CALM2 1 GO:1904424 regulation of GTP binding 1/436 15/18722 0.297835267373929 0.669647595231956 STMN1 1 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 1/436 15/18722 0.297835267373929 0.669647595231956 CCT5 1 GO:1990169 stress response to copper ion 1/436 15/18722 0.297835267373929 0.669647595231956 MT2A 1 GO:2001138 regulation of phospholipid transport 1/436 15/18722 0.297835267373929 0.669647595231956 DBI 1 GO:0043242 negative regulation of protein-containing complex disassembly 3/436 82/18722 0.29850770628783 0.669647595231956 TPX2/CKAP2/RDX 3 GO:0046364 monosaccharide biosynthetic process 3/436 82/18722 0.29850770628783 0.669647595231956 PGP/SLC25A1/TPI1 3 GO:1905897 regulation of response to endoplasmic reticulum stress 3/436 82/18722 0.29850770628783 0.669647595231956 SVIP/BAX/ERP29 3 GO:0009261 ribonucleotide catabolic process 2/436 47/18722 0.299399420310644 0.669647595231956 NUDT8/HINT1 2 GO:0016073 snRNA metabolic process 2/436 47/18722 0.299399420310644 0.669647595231956 EXOSC9/EXOSC8 2 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 2/436 47/18722 0.299399420310644 0.669647595231956 CHEK1/JUN 2 GO:0045581 negative regulation of T cell differentiation 2/436 47/18722 0.299399420310644 0.669647595231956 HMGB1/PRDX2 2 GO:0045646 regulation of erythrocyte differentiation 2/436 47/18722 0.299399420310644 0.669647595231956 HMGB2/PRKDC 2 GO:0046677 response to antibiotic 2/436 47/18722 0.299399420310644 0.669647595231956 EZH2/HSP90AA1 2 GO:0050798 activated T cell proliferation 2/436 47/18722 0.299399420310644 0.669647595231956 HMGB1/RPS3 2 GO:0097300 programmed necrotic cell death 2/436 47/18722 0.299399420310644 0.669647595231956 PPIF/BAX 2 GO:0051051 negative regulation of transport 13/436 470/18722 0.302458239548744 0.676048351721003 HMGB1/BARD1/HADH/CALM2/PPIF/SVIP/PNKD/IDH2/VDAC1/GSTO1/LMAN1/ERP29/LRPAP1 13 GO:0051017 actin filament bundle assembly 5/436 157/18722 0.303251090690808 0.67693851149002 STMN1/ID1/TACSTD2/PDLIM1/RDX 5 GO:0070646 protein modification by small protein removal 5/436 157/18722 0.303251090690808 0.67693851149002 CDK1/USP1/HINT1/COPS3/USP48 5 GO:0051899 membrane depolarization 3/436 83/18722 0.304888752526219 0.680151696955435 YWHAH/PARP1/JUN 3 GO:0032411 positive regulation of transporter activity 4/436 120/18722 0.306136547629738 0.681429714612217 CALM2/ATP1B3/GSTO1/NDUFA4 4 GO:0048593 camera-type eye morphogenesis 4/436 120/18722 0.306136547629738 0.681429714612217 FAT1/HMGN1/BAX/C12orf57 4 GO:0031032 actomyosin structure organization 6/436 196/18722 0.306801881191947 0.681429714612217 STMN1/ANLN/CSRP2/MYH10/TACSTD2/PDLIM1 6 GO:0032527 protein exit from endoplasmic reticulum 2/436 48/18722 0.308033450499163 0.681429714612217 SVIP/CD81 2 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 2/436 48/18722 0.308033450499163 0.681429714612217 ITM2C/PDIA3 2 GO:0071248 cellular response to metal ion 6/436 197/18722 0.310875063324898 0.681429714612217 MT2A/FUS/PARP1/CACYBP/JUN/PPIF 6 GO:0010921 regulation of phosphatase activity 3/436 84/18722 0.311275458092299 0.681429714612217 MASTL/CALM2/SLC39A10 3 GO:0042440 pigment metabolic process 3/436 84/18722 0.311275458092299 0.681429714612217 GMPS/PAICS/DDT 3 GO:1900542 regulation of purine nucleotide metabolic process 3/436 84/18722 0.311275458092299 0.681429714612217 PARP1/ENO1/PGAM1 3 GO:0042177 negative regulation of protein catabolic process 4/436 121/18722 0.311396018937999 0.681429714612217 MAD2L1/PBK/SVIP/RPS7 4 GO:0018105 peptidyl-serine phosphorylation 9/436 315/18722 0.313735516796511 0.681429714612217 CLSPN/CDK1/VRK1/MASTL/AURKB/TTK/PRKDC/HSP90AA1/BAX 9 GO:0001977 renal system process involved in regulation of blood volume 1/436 16/18722 0.314200468818574 0.681429714612217 EMP2 1 GO:0002830 positive regulation of type 2 immune response 1/436 16/18722 0.314200468818574 0.681429714612217 CD81 1 GO:0005980 glycogen catabolic process 1/436 16/18722 0.314200468818574 0.681429714612217 HMGB1 1 GO:0006349 regulation of gene expression by genetic imprinting 1/436 16/18722 0.314200468818574 0.681429714612217 BRCA1 1 GO:0006555 methionine metabolic process 1/436 16/18722 0.314200468818574 0.681429714612217 MTAP 1 GO:0006740 NADPH regeneration 1/436 16/18722 0.314200468818574 0.681429714612217 PGAM1 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/436 16/18722 0.314200468818574 0.681429714612217 BRCA1 1 GO:0010649 regulation of cell communication by electrical coupling 1/436 16/18722 0.314200468818574 0.681429714612217 CALM2 1 GO:0030540 female genitalia development 1/436 16/18722 0.314200468818574 0.681429714612217 BAX 1 GO:0030575 nuclear body organization 1/436 16/18722 0.314200468818574 0.681429714612217 SERBP1 1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 1/436 16/18722 0.314200468818574 0.681429714612217 EZH2 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/436 16/18722 0.314200468818574 0.681429714612217 CDKN2A 1 GO:0035970 peptidyl-threonine dephosphorylation 1/436 16/18722 0.314200468818574 0.681429714612217 PPM1G 1 GO:0044849 estrous cycle 1/436 16/18722 0.314200468818574 0.681429714612217 PCNA 1 GO:0045721 negative regulation of gluconeogenesis 1/436 16/18722 0.314200468818574 0.681429714612217 PGP 1 GO:0046036 CTP metabolic process 1/436 16/18722 0.314200468818574 0.681429714612217 NME1 1 GO:0046037 GMP metabolic process 1/436 16/18722 0.314200468818574 0.681429714612217 GMPS 1 GO:0048385 regulation of retinoic acid receptor signaling pathway 1/436 16/18722 0.314200468818574 0.681429714612217 EZH2 1 GO:0050884 neuromuscular process controlling posture 1/436 16/18722 0.314200468818574 0.681429714612217 PNKD 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/436 16/18722 0.314200468818574 0.681429714612217 BAX 1 GO:0070242 thymocyte apoptotic process 1/436 16/18722 0.314200468818574 0.681429714612217 BAX 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/436 16/18722 0.314200468818574 0.681429714612217 HMGB1 1 GO:0097202 activation of cysteine-type endopeptidase activity 1/436 16/18722 0.314200468818574 0.681429714612217 PERP 1 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 1/436 16/18722 0.314200468818574 0.681429714612217 NSG1 1 GO:0099010 modification of postsynaptic structure 1/436 16/18722 0.314200468818574 0.681429714612217 MYH10 1 GO:0099633 protein localization to postsynaptic specialization membrane 1/436 16/18722 0.314200468818574 0.681429714612217 HRAS 1 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 1/436 16/18722 0.314200468818574 0.681429714612217 HRAS 1 GO:1901163 regulation of trophoblast cell migration 1/436 16/18722 0.314200468818574 0.681429714612217 C1QBP 1 GO:1902570 protein localization to nucleolus 1/436 16/18722 0.314200468818574 0.681429714612217 RAN 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/436 16/18722 0.314200468818574 0.681429714612217 EMP2 1 GO:2001212 regulation of vasculogenesis 1/436 16/18722 0.314200468818574 0.681429714612217 EMP2 1 GO:2001224 positive regulation of neuron migration 1/436 16/18722 0.314200468818574 0.681429714612217 KIF20B 1 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/436 16/18722 0.314200468818574 0.681429714612217 BAX 1 GO:0001913 T cell mediated cytotoxicity 2/436 49/18722 0.31664625167528 0.681564171579602 EMP2/CTSH 2 GO:0006376 mRNA splice site selection 2/436 49/18722 0.31664625167528 0.681564171579602 PSIP1/SRSF10 2 GO:0006692 prostanoid metabolic process 2/436 49/18722 0.31664625167528 0.681564171579602 GSTP1/PTGES3 2 GO:0006693 prostaglandin metabolic process 2/436 49/18722 0.31664625167528 0.681564171579602 GSTP1/PTGES3 2 GO:0009409 response to cold 2/436 49/18722 0.31664625167528 0.681564171579602 HSP90AA1/HSPD1 2 GO:0009994 oocyte differentiation 2/436 49/18722 0.31664625167528 0.681564171579602 FBXO5/BRCA2 2 GO:0014075 response to amine 2/436 49/18722 0.31664625167528 0.681564171579602 CDK1/NME1 2 GO:0043457 regulation of cellular respiration 2/436 49/18722 0.31664625167528 0.681564171579602 PPIF/UQCC2 2 GO:0046580 negative regulation of Ras protein signal transduction 2/436 49/18722 0.31664625167528 0.681564171579602 STMN1/NUP62 2 GO:0051932 synaptic transmission, GABAergic 2/436 49/18722 0.31664625167528 0.681564171579602 EZH2/ZDHHC12 2 GO:0072091 regulation of stem cell proliferation 2/436 49/18722 0.31664625167528 0.681564171579602 HMGB2/CCNE1 2 GO:1901799 negative regulation of proteasomal protein catabolic process 2/436 49/18722 0.31664625167528 0.681564171579602 PBK/SVIP 2 GO:0043414 macromolecule methylation 9/436 316/18722 0.316954177097958 0.681799236127332 HELLS/BRCA1/EZH2/PARP1/SNRPB/MGMT/SUZ12/RIF1/SNRPD3 9 GO:0002709 regulation of T cell mediated immunity 3/436 85/18722 0.317665941399258 0.682474542855889 HMGB1/CD81/HSPD1 3 GO:0071277 cellular response to calcium ion 3/436 85/18722 0.317665941399258 0.682474542855889 FUS/CACYBP/PPIF 3 GO:0061572 actin filament bundle organization 5/436 161/18722 0.321514801119964 0.690311190639922 STMN1/ID1/TACSTD2/PDLIM1/RDX 5 GO:0050852 T cell receptor signaling pathway 4/436 123/18722 0.3219392520836 0.690790227579007 CD81/HRAS/RPS3/KHDRBS1 4 GO:0070661 leukocyte proliferation 9/436 318/18722 0.323412221475214 0.691749306409068 HELLS/HMGB1/PRDX2/GSTP1/CD81/RPS3/BAX/SLC39A10/HSPD1 9 GO:0006140 regulation of nucleotide metabolic process 3/436 86/18722 0.324058362254127 0.691749306409068 PARP1/ENO1/PGAM1 3 GO:0007140 male meiotic nuclear division 2/436 50/18722 0.325234136089395 0.691749306409068 BRCA2/RAD51C 2 GO:0060688 regulation of morphogenesis of a branching structure 2/436 50/18722 0.325234136089395 0.691749306409068 TACSTD2/PHB2 2 GO:0090102 cochlea development 2/436 50/18722 0.325234136089395 0.691749306409068 CCNA2/MCM2 2 GO:1903747 regulation of establishment of protein localization to mitochondrion 2/436 50/18722 0.325234136089395 0.691749306409068 SAE1/LMAN1 2 GO:0051100 negative regulation of binding 5/436 162/18722 0.326101603064783 0.691749306409068 AURKB/ID1/JUN/BAX/LRPAP1 5 GO:0071496 cellular response to external stimulus 9/436 320/18722 0.329896205576772 0.691749306409068 CHEK1/DCTPP1/CASP8AP2/NUDT1/JUN/NUDT15/GSTP1/CTSV/HSPA8 9 GO:0000097 sulfur amino acid biosynthetic process 1/436 17/18722 0.330185104528779 0.691749306409068 MTAP 1 GO:0001780 neutrophil homeostasis 1/436 17/18722 0.330185104528779 0.691749306409068 HMGB1 1 GO:0006390 mitochondrial transcription 1/436 17/18722 0.330185104528779 0.691749306409068 TFAM 1 GO:0008334 histone mRNA metabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 SLBP 1 GO:0009251 glucan catabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 HMGB1 1 GO:0016264 gap junction assembly 1/436 17/18722 0.330185104528779 0.691749306409068 CNTNAP2 1 GO:0021756 striatum development 1/436 17/18722 0.330185104528779 0.691749306409068 CNTNAP2 1 GO:0021924 cell proliferation in external granule layer 1/436 17/18722 0.330185104528779 0.691749306409068 PSMG1 1 GO:0021930 cerebellar granule cell precursor proliferation 1/436 17/18722 0.330185104528779 0.691749306409068 PSMG1 1 GO:0030903 notochord development 1/436 17/18722 0.330185104528779 0.691749306409068 ID3 1 GO:0032048 cardiolipin metabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 PHB2 1 GO:0042053 regulation of dopamine metabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 PNKD 1 GO:0042069 regulation of catecholamine metabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 PNKD 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/436 17/18722 0.330185104528779 0.691749306409068 SUZ12 1 GO:0043968 histone H2A acetylation 1/436 17/18722 0.330185104528779 0.691749306409068 YEATS4 1 GO:0044539 long-chain fatty acid import into cell 1/436 17/18722 0.330185104528779 0.691749306409068 SLC27A2 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/436 17/18722 0.330185104528779 0.691749306409068 FAT1 1 GO:0046827 positive regulation of protein export from nucleus 1/436 17/18722 0.330185104528779 0.691749306409068 ANP32B 1 GO:0046855 inositol phosphate dephosphorylation 1/436 17/18722 0.330185104528779 0.691749306409068 IMPA2 1 GO:0060644 mammary gland epithelial cell differentiation 1/436 17/18722 0.330185104528779 0.691749306409068 MGMT 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/436 17/18722 0.330185104528779 0.691749306409068 HNRNPD 1 GO:0061450 trophoblast cell migration 1/436 17/18722 0.330185104528779 0.691749306409068 C1QBP 1 GO:0070875 positive regulation of glycogen metabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 HMGB1 1 GO:0071371 cellular response to gonadotropin stimulus 1/436 17/18722 0.330185104528779 0.691749306409068 CCNA2 1 GO:0090713 immunological memory process 1/436 17/18722 0.330185104528779 0.691749306409068 CD81 1 GO:0140354 lipid import into cell 1/436 17/18722 0.330185104528779 0.691749306409068 SLC27A2 1 GO:1901569 fatty acid derivative catabolic process 1/436 17/18722 0.330185104528779 0.691749306409068 NUDT8 1 GO:1903540 establishment of protein localization to postsynaptic membrane 1/436 17/18722 0.330185104528779 0.691749306409068 NSG1 1 GO:0001776 leukocyte homeostasis 3/436 87/18722 0.330450921948255 0.691749306409068 HMGB1/CCNB2/BAX 3 GO:0019646 aerobic electron transport chain 3/436 87/18722 0.330450921948255 0.691749306409068 COX5A/COX8A/NDUFA4 3 GO:0051262 protein tetramerization 3/436 87/18722 0.330450921948255 0.691749306409068 RRM2/RRM1/TK1 3 GO:1901879 regulation of protein depolymerization 3/436 87/18722 0.330450921948255 0.691749306409068 TPX2/CKAP2/RDX 3 GO:0045936 negative regulation of phosphate metabolic process 12/436 441/18722 0.332236355611786 0.695062765917097 PBK/MASTL/CALM2/PRKDC/NUP62/PARP1/PPIA/CDKN2A/GSTP1/SUZ12/CTDSPL/BAX 12 GO:0065002 intracellular protein transmembrane transport 2/436 51/18722 0.333793598470294 0.697895086137465 TOMM40/HSPD1 2 GO:0010563 negative regulation of phosphorus metabolic process 12/436 442/18722 0.335008265537802 0.699728508345864 PBK/MASTL/CALM2/PRKDC/NUP62/PARP1/PPIA/CDKN2A/GSTP1/SUZ12/CTDSPL/BAX 12 GO:0002700 regulation of production of molecular mediator of immune response 5/436 164/18722 0.33529522811188 0.699728508345864 MSH2/PRKDC/CD81/RIF1/PHB2 5 GO:0032869 cellular response to insulin stimulus 6/436 203/18722 0.335486271124729 0.699728508345864 PRKDC/PARP1/CDK4/NUCKS1/GSTP1/SNX5 6 GO:0060541 respiratory system development 6/436 203/18722 0.335486271124729 0.699728508345864 HMGB1/EIF4EBP1/HSPB11/DPPA4/PTGES3/CTSH 6 GO:0001843 neural tube closure 3/436 88/18722 0.336841863298383 0.702129060131684 KIF20B/RPS7/SPINT2 3 GO:0051146 striated muscle cell differentiation 8/436 283/18722 0.339308466681135 0.704114512477488 CDK1/EZH2/CACYBP/PARP2/CSRP2/CD81/YBX1/GPX1 8 GO:0071383 cellular response to steroid hormone stimulus 6/436 204/18722 0.339611996442374 0.704114512477488 BRCA1/YWHAH/PARP1/GSTP1/PTGES3/PHB2 6 GO:0031103 axon regeneration 2/436 52/18722 0.342321309559645 0.704114512477488 DHFR/NREP 2 GO:0043392 negative regulation of DNA binding 2/436 52/18722 0.342321309559645 0.704114512477488 ID1/JUN 2 GO:0060606 tube closure 3/436 89/18722 0.343229470641052 0.704114512477488 KIF20B/RPS7/SPINT2 3 GO:0098656 anion transmembrane transport 7/436 245/18722 0.345619386418243 0.704114512477488 SLC25A5/SLC25A1/SLC20A1/MPC2/VDAC3/SLC25A6/VDAC1 7 GO:0000712 resolution of meiotic recombination intermediates 1/436 18/18722 0.345798004524794 0.704114512477488 TOP2A 1 GO:0002643 regulation of tolerance induction 1/436 18/18722 0.345798004524794 0.704114512477488 HMGB1 1 GO:0006085 acetyl-CoA biosynthetic process 1/436 18/18722 0.345798004524794 0.704114512477488 MPC2 1 GO:0006103 2-oxoglutarate metabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 IDH2 1 GO:0007549 dosage compensation 1/436 18/18722 0.345798004524794 0.704114512477488 BRCA1 1 GO:0009125 nucleoside monophosphate catabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 DNPH1 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 NME1 1 GO:0010985 negative regulation of lipoprotein particle clearance 1/436 18/18722 0.345798004524794 0.704114512477488 LRPAP1 1 GO:0015936 coenzyme A metabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 NUDT8 1 GO:0021534 cell proliferation in hindbrain 1/436 18/18722 0.345798004524794 0.704114512477488 PSMG1 1 GO:0032785 negative regulation of DNA-templated transcription, elongation 1/436 18/18722 0.345798004524794 0.704114512477488 EZH2 1 GO:0033189 response to vitamin A 1/436 18/18722 0.345798004524794 0.704114512477488 TYMS 1 GO:0034134 toll-like receptor 2 signaling pathway 1/436 18/18722 0.345798004524794 0.704114512477488 HMGB1 1 GO:0034162 toll-like receptor 9 signaling pathway 1/436 18/18722 0.345798004524794 0.704114512477488 HMGB1 1 GO:0035372 protein localization to microtubule 1/436 18/18722 0.345798004524794 0.704114512477488 KIF20B 1 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 1/436 18/18722 0.345798004524794 0.704114512477488 CD81 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/436 18/18722 0.345798004524794 0.704114512477488 TCOF1 1 GO:0044247 cellular polysaccharide catabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 HMGB1 1 GO:0045116 protein neddylation 1/436 18/18722 0.345798004524794 0.704114512477488 NAE1 1 GO:0046040 IMP metabolic process 1/436 18/18722 0.345798004524794 0.704114512477488 PAICS 1 GO:0046838 phosphorylated carbohydrate dephosphorylation 1/436 18/18722 0.345798004524794 0.704114512477488 IMPA2 1 GO:0055070 copper ion homeostasis 1/436 18/18722 0.345798004524794 0.704114512477488 MT2A 1 GO:0060008 Sertoli cell differentiation 1/436 18/18722 0.345798004524794 0.704114512477488 CTSV 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/436 18/18722 0.345798004524794 0.704114512477488 PARP1 1 GO:0061687 detoxification of inorganic compound 1/436 18/18722 0.345798004524794 0.704114512477488 MT2A 1 GO:0097094 craniofacial suture morphogenesis 1/436 18/18722 0.345798004524794 0.704114512477488 TMEM107 1 GO:0097107 postsynaptic density assembly 1/436 18/18722 0.345798004524794 0.704114512477488 ZDHHC12 1 GO:0098877 neurotransmitter receptor transport to plasma membrane 1/436 18/18722 0.345798004524794 0.704114512477488 NSG1 1 GO:1900006 positive regulation of dendrite development 1/436 18/18722 0.345798004524794 0.704114512477488 EZH2 1 GO:1902074 response to salt 1/436 18/18722 0.345798004524794 0.704114512477488 HNRNPD 1 GO:1902683 regulation of receptor localization to synapse 1/436 18/18722 0.345798004524794 0.704114512477488 HRAS 1 GO:1904872 regulation of telomerase RNA localization to Cajal body 1/436 18/18722 0.345798004524794 0.704114512477488 CCT5 1 GO:2000641 regulation of early endosome to late endosome transport 1/436 18/18722 0.345798004524794 0.704114512477488 RDX 1 GO:0035303 regulation of dephosphorylation 4/436 128/18722 0.348389009982916 0.708969568951 MASTL/CALM2/PPIA/SLC39A10 4 GO:0007254 JNK cascade 5/436 167/18722 0.349125159928851 0.709354826390013 HMGB1/HACD3/GSTP1/MARVELD3/HRAS 5 GO:0034767 positive regulation of ion transmembrane transport 5/436 167/18722 0.349125159928851 0.709354826390013 CALM2/ATP1B3/BAX/GSTO1/NDUFA4 5 GO:0031668 cellular response to extracellular stimulus 7/436 246/18722 0.349400874681192 0.709354826390013 DCTPP1/NUDT1/JUN/NUDT15/GSTP1/CTSV/HSPA8 7 GO:0030901 midbrain development 3/436 90/18722 0.349612069783012 0.709354826390013 YWHAH/CALM2/WLS 3 GO:0048477 oogenesis 3/436 90/18722 0.349612069783012 0.709354826390013 FBXO5/BRCA2/ASPM 3 GO:0007566 embryo implantation 2/436 53/18722 0.350814109847535 0.710533182341732 EMP2/C1QBP 2 GO:0043620 regulation of DNA-templated transcription in response to stress 2/436 53/18722 0.350814109847535 0.710533182341732 CHEK1/JUN 2 GO:1903202 negative regulation of oxidative stress-induced cell death 2/436 53/18722 0.350814109847535 0.710533182341732 PPIA/GPX1 2 GO:0050679 positive regulation of epithelial cell proliferation 6/436 207/18722 0.352019869348871 0.712554673590546 HMGB2/HMGB1/ID1/NME1/HRAS/CCND1 6 GO:0034101 erythrocyte homeostasis 4/436 129/18722 0.353686356962733 0.713568538377496 HMGB2/PRKDC/SLC25A5/RPS17 4 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5/436 168/18722 0.353742896837934 0.713568538377496 HMGB1/MSH2/CD81/RIF1/HSPD1 5 GO:0042147 retrograde transport, endosome to Golgi 3/436 91/18722 0.355988027910163 0.713568538377496 SNX5/PLEKHJ1/VPS29 3 GO:1901215 negative regulation of neuron death 6/436 208/18722 0.356164386471587 0.713568538377496 MSH2/PARP2/SET/HRAS/BAX/HSPD1 6 GO:0046651 lymphocyte proliferation 8/436 288/18722 0.356822900441776 0.713568538377496 HELLS/HMGB1/PRDX2/CD81/RPS3/BAX/SLC39A10/HSPD1 8 GO:0021543 pallium development 5/436 169/18722 0.358363377507592 0.713568538377496 EZH2/CNTNAP2/ASPM/NME1/BAX 5 GO:0006584 catecholamine metabolic process 2/436 54/18722 0.359269003503239 0.713568538377496 PNKD/LY6E 2 GO:0009712 catechol-containing compound metabolic process 2/436 54/18722 0.359269003503239 0.713568538377496 PNKD/LY6E 2 GO:0070839 metal ion export 2/436 54/18722 0.359269003503239 0.713568538377496 CALM2/ATP1B3 2 GO:2000179 positive regulation of neural precursor cell proliferation 2/436 54/18722 0.359269003503239 0.713568538377496 ASPM/NAP1L1 2 GO:0000729 DNA double-strand break processing 1/436 19/18722 0.361047794410764 0.713568538377496 BLM 1 GO:0002281 macrophage activation involved in immune response 1/436 19/18722 0.361047794410764 0.713568538377496 HMGB1 1 GO:0006007 glucose catabolic process 1/436 19/18722 0.361047794410764 0.713568538377496 ENO1 1 GO:0006309 apoptotic DNA fragmentation 1/436 19/18722 0.361047794410764 0.713568538377496 BAX 1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1/436 19/18722 0.361047794410764 0.713568538377496 GTSE1 1 GO:0007039 protein catabolic process in the vacuole 1/436 19/18722 0.361047794410764 0.713568538377496 CD81 1 GO:0008356 asymmetric cell division 1/436 19/18722 0.361047794410764 0.713568538377496 ASPM 1 GO:0009081 branched-chain amino acid metabolic process 1/436 19/18722 0.361047794410764 0.713568538377496 ECHS1 1 GO:0030011 maintenance of cell polarity 1/436 19/18722 0.361047794410764 0.713568538377496 PDLIM1 1 GO:0030220 platelet formation 1/436 19/18722 0.361047794410764 0.713568538377496 PRKDC 1 GO:0032026 response to magnesium ion 1/436 19/18722 0.361047794410764 0.713568538377496 CCND1 1 GO:0032695 negative regulation of interleukin-12 production 1/436 19/18722 0.361047794410764 0.713568538377496 C1QBP 1 GO:0033194 response to hydroperoxide 1/436 19/18722 0.361047794410764 0.713568538377496 GPX1 1 GO:0036344 platelet morphogenesis 1/436 19/18722 0.361047794410764 0.713568538377496 PRKDC 1 GO:0036498 IRE1-mediated unfolded protein response 1/436 19/18722 0.361047794410764 0.713568538377496 BAX 1 GO:0044003 modulation by symbiont of host process 1/436 19/18722 0.361047794410764 0.713568538377496 PHB2 1 GO:0044320 cellular response to leptin stimulus 1/436 19/18722 0.361047794410764 0.713568538377496 CCNA2 1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/436 19/18722 0.361047794410764 0.713568538377496 TOP2A 1 GO:0045947 negative regulation of translational initiation 1/436 19/18722 0.361047794410764 0.713568538377496 EIF4EBP1 1 GO:0046794 transport of virus 1/436 19/18722 0.361047794410764 0.713568538377496 DYNLT1 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/436 19/18722 0.361047794410764 0.713568538377496 BRCA1 1 GO:0071545 inositol phosphate catabolic process 1/436 19/18722 0.361047794410764 0.713568538377496 IMPA2 1 GO:0090670 RNA localization to Cajal body 1/436 19/18722 0.361047794410764 0.713568538377496 CCT5 1 GO:0090671 telomerase RNA localization to Cajal body 1/436 19/18722 0.361047794410764 0.713568538377496 CCT5 1 GO:0090672 telomerase RNA localization 1/436 19/18722 0.361047794410764 0.713568538377496 CCT5 1 GO:0090685 RNA localization to nucleus 1/436 19/18722 0.361047794410764 0.713568538377496 CCT5 1 GO:0097501 stress response to metal ion 1/436 19/18722 0.361047794410764 0.713568538377496 MT2A 1 GO:1900221 regulation of amyloid-beta clearance 1/436 19/18722 0.361047794410764 0.713568538377496 LRPAP1 1 GO:1903975 regulation of glial cell migration 1/436 19/18722 0.361047794410764 0.713568538377496 IDH2 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/436 19/18722 0.361047794410764 0.713568538377496 HRAS 1 GO:2000738 positive regulation of stem cell differentiation 1/436 19/18722 0.361047794410764 0.713568538377496 TACSTD2 1 GO:0031058 positive regulation of histone modification 3/436 92/18722 0.362355753457477 0.715741272373404 BRCA1/RIF1/BRD7 3 GO:0071375 cellular response to peptide hormone stimulus 8/436 290/18722 0.363858216582617 0.718295478190424 CDC6/CCNA2/PRKDC/PARP1/CDK4/NUCKS1/GSTP1/SNX5 8 GO:0018022 peptidyl-lysine methylation 4/436 131/18722 0.364280420036717 0.7183023684747 BRCA1/EZH2/SUZ12/RIF1 4 GO:0019827 stem cell population maintenance 4/436 131/18722 0.364280420036717 0.7183023684747 SMC3/ASPM/SMC1A/RIF1 4 GO:0045862 positive regulation of proteolysis 10/436 372/18722 0.367294255050136 0.720804933546356 HMGB1/CASP8AP2/ANP32B/ENO1/PSMC3/RPS3/BAX/PERP/HSPD1/CTSH 10 GO:0032943 mononuclear cell proliferation 8/436 291/18722 0.367380989008838 0.720804933546356 HELLS/HMGB1/PRDX2/CD81/RPS3/BAX/SLC39A10/HSPD1 8 GO:0006360 transcription by RNA polymerase I 2/436 55/18722 0.367683152495539 0.720804933546356 TCOF1/POLR2L 2 GO:0031113 regulation of microtubule polymerization 2/436 55/18722 0.367683152495539 0.720804933546356 STMN1/RPS3 2 GO:0042220 response to cocaine 2/436 55/18722 0.367683152495539 0.720804933546356 CCNA2/HSPD1 2 GO:0045620 negative regulation of lymphocyte differentiation 2/436 55/18722 0.367683152495539 0.720804933546356 HMGB1/PRDX2 2 GO:0046164 alcohol catabolic process 2/436 55/18722 0.367683152495539 0.720804933546356 IMPA2/TPI1 2 GO:0007589 body fluid secretion 3/436 93/18722 0.368713695942221 0.720804933546356 SLC29A1/NME1/CCND1 3 GO:0033108 mitochondrial respiratory chain complex assembly 3/436 93/18722 0.368713695942221 0.720804933546356 TFAM/UQCC2/COX14 3 GO:0051591 response to cAMP 3/436 93/18722 0.368713695942221 0.720804933546356 JUN/NME1/LDHA 3 GO:0043434 response to peptide hormone 11/436 414/18722 0.371098963392589 0.720804933546356 CDC6/CCNA2/HADH/PRKDC/PARP1/CDK4/CACYBP/NUCKS1/GGH/GSTP1/SNX5 11 GO:0010951 negative regulation of endopeptidase activity 7/436 252/18722 0.372171774320691 0.720804933546356 BIRC5/DHCR24/BCL2L12/PEBP1/SPINT2/APLP2/GPX1 7 GO:0030258 lipid modification 6/436 212/18722 0.372772073083623 0.720804933546356 ACAT2/HADH/SLC27A2/ECI1/ETFB/ECHS1 6 GO:0046328 regulation of JNK cascade 4/436 133/18722 0.374867207034371 0.720804933546356 HMGB1/GSTP1/MARVELD3/HRAS 4 GO:0014020 primary neural tube formation 3/436 94/18722 0.375060345762733 0.720804933546356 KIF20B/RPS7/SPINT2 3 GO:0019080 viral gene expression 3/436 94/18722 0.375060345762733 0.720804933546356 JUN/NUCKS1/PSMC3 3 GO:0000272 polysaccharide catabolic process 1/436 20/18722 0.375942900096318 0.720804933546356 HMGB1 1 GO:0006346 DNA methylation-dependent heterochromatin assembly 1/436 20/18722 0.375942900096318 0.720804933546356 HELLS 1 GO:0006607 NLS-bearing protein import into nucleus 1/436 20/18722 0.375942900096318 0.720804933546356 KPNB1 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/436 20/18722 0.375942900096318 0.720804933546356 VDAC1 1 GO:0006883 cellular sodium ion homeostasis 1/436 20/18722 0.375942900096318 0.720804933546356 ATP1B3 1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1/436 20/18722 0.375942900096318 0.720804933546356 CALM2 1 GO:0030150 protein import into mitochondrial matrix 1/436 20/18722 0.375942900096318 0.720804933546356 TOMM40 1 GO:0032930 positive regulation of superoxide anion generation 1/436 20/18722 0.375942900096318 0.720804933546356 GSTP1 1 GO:0039535 regulation of RIG-I signaling pathway 1/436 20/18722 0.375942900096318 0.720804933546356 C1QBP 1 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 1/436 20/18722 0.375942900096318 0.720804933546356 TOP2A 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/436 20/18722 0.375942900096318 0.720804933546356 ITM2C 1 GO:0043651 linoleic acid metabolic process 1/436 20/18722 0.375942900096318 0.720804933546356 GSTP1 1 GO:0043984 histone H4-K16 acetylation 1/436 20/18722 0.375942900096318 0.720804933546356 BRCA1 1 GO:0045063 T-helper 1 cell differentiation 1/436 20/18722 0.375942900096318 0.720804933546356 HMGB1 1 GO:0046485 ether lipid metabolic process 1/436 20/18722 0.375942900096318 0.720804933546356 CHPT1 1 GO:0051900 regulation of mitochondrial depolarization 1/436 20/18722 0.375942900096318 0.720804933546356 PARP1 1 GO:0071625 vocalization behavior 1/436 20/18722 0.375942900096318 0.720804933546356 CNTNAP2 1 GO:0072567 chemokine (C-X-C motif) ligand 2 production 1/436 20/18722 0.375942900096318 0.720804933546356 HMGB1 1 GO:0097150 neuronal stem cell population maintenance 1/436 20/18722 0.375942900096318 0.720804933546356 ASPM 1 GO:1904292 regulation of ERAD pathway 1/436 20/18722 0.375942900096318 0.720804933546356 SVIP 1 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 1/436 20/18722 0.375942900096318 0.720804933546356 HMGB1 1 GO:0009743 response to carbohydrate 7/436 253/18722 0.375977056706293 0.720804933546356 CDT1/SLC29A1/GSTP1/CTSV/NME1/MPC2/LDHA 7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/436 56/18722 0.376053870897108 0.720804933546356 EXOSC9/EXOSC8 2 GO:0002711 positive regulation of T cell mediated immunity 2/436 56/18722 0.376053870897108 0.720804933546356 CD81/HSPD1 2 GO:0010518 positive regulation of phospholipase activity 2/436 56/18722 0.376053870897108 0.720804933546356 HRAS/PHB2 2 GO:0031122 cytoplasmic microtubule organization 2/436 56/18722 0.376053870897108 0.720804933546356 KPNB1/CENPJ 2 GO:0042733 embryonic digit morphogenesis 2/436 56/18722 0.376053870897108 0.720804933546356 TMEM107/BAX 2 GO:0043470 regulation of carbohydrate catabolic process 2/436 56/18722 0.376053870897108 0.720804933546356 HMGB1/PGAM1 2 GO:0045071 negative regulation of viral genome replication 2/436 56/18722 0.376053870897108 0.720804933546356 SRPK1/ILF3 2 GO:0046622 positive regulation of organ growth 2/436 56/18722 0.376053870897108 0.720804933546356 CDK1/PARP2 2 GO:0051058 negative regulation of small GTPase mediated signal transduction 2/436 56/18722 0.376053870897108 0.720804933546356 STMN1/NUP62 2 GO:0055078 sodium ion homeostasis 2/436 56/18722 0.376053870897108 0.720804933546356 ATP1B3/SNX5 2 GO:0070534 protein K63-linked ubiquitination 2/436 56/18722 0.376053870897108 0.720804933546356 UBE2T/UBE2S 2 GO:0098781 ncRNA transcription 2/436 56/18722 0.376053870897108 0.720804933546356 TCOF1/POLR2L 2 GO:0006694 steroid biosynthetic process 5/436 173/18722 0.376859415778443 0.721945647982043 FDPS/DHCR24/SLC27A2/SQLE/HINT2 5 GO:0006942 regulation of striated muscle contraction 3/436 95/18722 0.381394233964877 0.726559932926475 CALM2/C12orf57/GSTO1 3 GO:0042982 amyloid precursor protein metabolic process 3/436 95/18722 0.381394233964877 0.726559932926475 DHCR24/NSG1/ITM2C 3 GO:0006695 cholesterol biosynthetic process 2/436 57/18722 0.384378619367594 0.726559932926475 FDPS/DHCR24 2 GO:0006754 ATP biosynthetic process 2/436 57/18722 0.384378619367594 0.726559932926475 PARP1/ENO1 2 GO:0033619 membrane protein proteolysis 2/436 57/18722 0.384378619367594 0.726559932926475 RBMX/CTSH 2 GO:0050879 multicellular organismal movement 2/436 57/18722 0.384378619367594 0.726559932926475 C12orf57/GSTO1 2 GO:0050881 musculoskeletal movement 2/436 57/18722 0.384378619367594 0.726559932926475 C12orf57/GSTO1 2 GO:0051205 protein insertion into membrane 2/436 57/18722 0.384378619367594 0.726559932926475 HSP90AA1/BAX 2 GO:0097120 receptor localization to synapse 2/436 57/18722 0.384378619367594 0.726559932926475 NSG1/HRAS 2 GO:1900024 regulation of substrate adhesion-dependent cell spreading 2/436 57/18722 0.384378619367594 0.726559932926475 TACSTD2/C1QBP 2 GO:1902653 secondary alcohol biosynthetic process 2/436 57/18722 0.384378619367594 0.726559932926475 FDPS/DHCR24 2 GO:0042157 lipoprotein metabolic process 4/436 135/18722 0.385439215069986 0.726559932926475 ZDHHC12/SVIP/PGAP2/DBI 4 GO:0034976 response to endoplasmic reticulum stress 7/436 256/18722 0.387402829705489 0.726559932926475 JUN/SDF2L1/SVIP/CCND1/BAX/PDIA3/ERP29 7 GO:0006637 acyl-CoA metabolic process 3/436 96/18722 0.387713931978242 0.726559932926475 NUDT8/SLC25A1/MPC2 3 GO:0010769 regulation of cell morphogenesis involved in differentiation 3/436 96/18722 0.387713931978242 0.726559932926475 PRKDC/TACSTD2/C1QBP 3 GO:0035383 thioester metabolic process 3/436 96/18722 0.387713931978242 0.726559932926475 NUDT8/SLC25A1/MPC2 3 GO:0000002 mitochondrial genome maintenance 1/436 21/18722 0.390491552409332 0.726559932926475 PARP1 1 GO:0002689 negative regulation of leukocyte chemotaxis 1/436 21/18722 0.390491552409332 0.726559932926475 DDT 1 GO:0006353 DNA-templated transcription, termination 1/436 21/18722 0.390491552409332 0.726559932926475 POLR3K 1 GO:0006450 regulation of translational fidelity 1/436 21/18722 0.390491552409332 0.726559932926475 RPS5 1 GO:0006925 inflammatory cell apoptotic process 1/436 21/18722 0.390491552409332 0.726559932926475 CDKN2A 1 GO:0007252 I-kappaB phosphorylation 1/436 21/18722 0.390491552409332 0.726559932926475 PRDX4 1 GO:0009067 aspartate family amino acid biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 MTAP 1 GO:0009070 serine family amino acid biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 DHFR 1 GO:0023019 signal transduction involved in regulation of gene expression 1/436 21/18722 0.390491552409332 0.726559932926475 PARP1 1 GO:0030449 regulation of complement activation 1/436 21/18722 0.390491552409332 0.726559932926475 C1QBP 1 GO:0033762 response to glucagon 1/436 21/18722 0.390491552409332 0.726559932926475 CCNA2 1 GO:0034312 diol biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 DHFR 1 GO:0035020 regulation of Rac protein signal transduction 1/436 21/18722 0.390491552409332 0.726559932926475 DYNLT1 1 GO:0035813 regulation of renal sodium excretion 1/436 21/18722 0.390491552409332 0.726559932926475 SNX5 1 GO:0044766 multi-organism transport 1/436 21/18722 0.390491552409332 0.726559932926475 DYNLT1 1 GO:0045056 transcytosis 1/436 21/18722 0.390491552409332 0.726559932926475 LRPAP1 1 GO:0045655 regulation of monocyte differentiation 1/436 21/18722 0.390491552409332 0.726559932926475 JUN 1 GO:0045717 negative regulation of fatty acid biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 BRCA1 1 GO:0046128 purine ribonucleoside metabolic process 1/436 21/18722 0.390491552409332 0.726559932926475 MTAP 1 GO:0046597 negative regulation of viral entry into host cell 1/436 21/18722 0.390491552409332 0.726559932926475 LY6E 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/436 21/18722 0.390491552409332 0.726559932926475 CD81 1 GO:0046823 negative regulation of nucleocytoplasmic transport 1/436 21/18722 0.390491552409332 0.726559932926475 BARD1 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 GSTP1 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 GSTP1 1 GO:0060972 left/right pattern formation 1/436 21/18722 0.390491552409332 0.726559932926475 HSPB11 1 GO:0070584 mitochondrion morphogenesis 1/436 21/18722 0.390491552409332 0.726559932926475 BAX 1 GO:0090026 positive regulation of monocyte chemotaxis 1/436 21/18722 0.390491552409332 0.726559932926475 HMGB1 1 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 1/436 21/18722 0.390491552409332 0.726559932926475 TACSTD2 1 GO:0098698 postsynaptic specialization assembly 1/436 21/18722 0.390491552409332 0.726559932926475 ZDHHC12 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/436 21/18722 0.390491552409332 0.726559932926475 SLC25A5 1 GO:1902307 positive regulation of sodium ion transmembrane transport 1/436 21/18722 0.390491552409332 0.726559932926475 ATP1B3 1 GO:1902473 regulation of protein localization to synapse 1/436 21/18722 0.390491552409332 0.726559932926475 HRAS 1 GO:1902579 multi-organism localization 1/436 21/18722 0.390491552409332 0.726559932926475 DYNLT1 1 GO:1902644 tertiary alcohol metabolic process 1/436 21/18722 0.390491552409332 0.726559932926475 AKR7A2 1 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 1/436 21/18722 0.390491552409332 0.726559932926475 HSPD1 1 GO:2000178 negative regulation of neural precursor cell proliferation 1/436 21/18722 0.390491552409332 0.726559932926475 SPINT2 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/436 21/18722 0.390491552409332 0.726559932926475 UQCC2 1 GO:0002697 regulation of immune effector process 9/436 339/18722 0.392402288480864 0.729003952569696 HMGB1/MSH2/PRKDC/CADM1/CD81/RIF1/C1QBP/HSPD1/PHB2 9 GO:0009161 ribonucleoside monophosphate metabolic process 2/436 58/18722 0.3926549998102 0.729003952569696 GMPS/PAICS 2 GO:0043506 regulation of JUN kinase activity 2/436 58/18722 0.3926549998102 0.729003952569696 GSTP1/RPS3 2 GO:2000736 regulation of stem cell differentiation 2/436 58/18722 0.3926549998102 0.729003952569696 PRKDC/TACSTD2 2 GO:0050671 positive regulation of lymphocyte proliferation 4/436 137/18722 0.39598919549665 0.73439942148595 HMGB1/CD81/RPS3/SLC39A10 4 GO:0050714 positive regulation of protein secretion 4/436 137/18722 0.39598919549665 0.73439942148595 PPIA/MYH10/MPC2/WLS 4 GO:1902903 regulation of supramolecular fiber organization 10/436 382/18722 0.398551053897284 0.737404061066294 STMN1/TPX2/ID1/CKAP2/HSPA8/ARPC5L/TACSTD2/RPS3/RDX/GPX1 10 GO:0032642 regulation of chemokine production 3/436 98/18722 0.40030524329662 0.737404061066294 HMGB1/GSTP1/SUZ12 3 GO:0006406 mRNA export from nucleus 2/436 59/18722 0.400880750196708 0.737404061066294 HNRNPA2B1/SRSF3 2 GO:0019369 arachidonic acid metabolic process 2/436 59/18722 0.400880750196708 0.737404061066294 PTGES3/GPX1 2 GO:0043407 negative regulation of MAP kinase activity 2/436 59/18722 0.400880750196708 0.737404061066294 NUP62/GSTP1 2 GO:0051353 positive regulation of oxidoreductase activity 2/436 59/18722 0.400880750196708 0.737404061066294 DHFR/NDUFA4 2 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 2/436 59/18722 0.400880750196708 0.737404061066294 HNRNPA2B1/SRSF3 2 GO:0071806 protein transmembrane transport 2/436 59/18722 0.400880750196708 0.737404061066294 TOMM40/HSPD1 2 GO:2001258 negative regulation of cation channel activity 2/436 59/18722 0.400880750196708 0.737404061066294 CALM2/GSTO1 2 GO:0032946 positive regulation of mononuclear cell proliferation 4/436 138/18722 0.401253730557466 0.737404061066294 HMGB1/CD81/RPS3/SLC39A10 4 GO:0002320 lymphoid progenitor cell differentiation 1/436 22/18722 0.404701791602399 0.737404061066294 PRKDC 1 GO:0006379 mRNA cleavage 1/436 22/18722 0.404701791602399 0.737404061066294 POLR2I 1 GO:0006662 glycerol ether metabolic process 1/436 22/18722 0.404701791602399 0.737404061066294 CHPT1 1 GO:0006907 pinocytosis 1/436 22/18722 0.404701791602399 0.737404061066294 SNX5 1 GO:0008211 glucocorticoid metabolic process 1/436 22/18722 0.404701791602399 0.737404061066294 YWHAH 1 GO:0009220 pyrimidine ribonucleotide biosynthetic process 1/436 22/18722 0.404701791602399 0.737404061066294 NME1 1 GO:0010310 regulation of hydrogen peroxide metabolic process 1/436 22/18722 0.404701791602399 0.737404061066294 PRDX2 1 GO:0016137 glycoside metabolic process 1/436 22/18722 0.404701791602399 0.737404061066294 AKR7A2 1 GO:0021854 hypothalamus development 1/436 22/18722 0.404701791602399 0.737404061066294 BAX 1 GO:0031061 negative regulation of histone methylation 1/436 22/18722 0.404701791602399 0.737404061066294 BRCA1 1 GO:0033617 mitochondrial cytochrome c oxidase assembly 1/436 22/18722 0.404701791602399 0.737404061066294 COX14 1 GO:0035024 negative regulation of Rho protein signal transduction 1/436 22/18722 0.404701791602399 0.737404061066294 STMN1 1 GO:0035089 establishment of apical/basal cell polarity 1/436 22/18722 0.404701791602399 0.737404061066294 FAT1 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/436 22/18722 0.404701791602399 0.737404061066294 HMGB1 1 GO:0048169 regulation of long-term neuronal synaptic plasticity 1/436 22/18722 0.404701791602399 0.737404061066294 HRAS 1 GO:0051412 response to corticosterone 1/436 22/18722 0.404701791602399 0.737404061066294 CCND1 1 GO:0055093 response to hyperoxia 1/436 22/18722 0.404701791602399 0.737404061066294 CDK4 1 GO:0060444 branching involved in mammary gland duct morphogenesis 1/436 22/18722 0.404701791602399 0.737404061066294 PHB2 1 GO:0060713 labyrinthine layer morphogenesis 1/436 22/18722 0.404701791602399 0.737404061066294 SPINT2 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/436 22/18722 0.404701791602399 0.737404061066294 CD81 1 GO:0099563 modification of synaptic structure 1/436 22/18722 0.404701791602399 0.737404061066294 MYH10 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/436 22/18722 0.404701791602399 0.737404061066294 PARP1 1 GO:2000114 regulation of establishment of cell polarity 1/436 22/18722 0.404701791602399 0.737404061066294 KIF20B 1 GO:0097529 myeloid leukocyte migration 6/436 220/18722 0.406029969288974 0.739245403002712 HMGB1/CKLF/PPIA/DDT/CD81/C1QBP 6 GO:0003300 cardiac muscle hypertrophy 3/436 99/18722 0.406574198620262 0.739245403002712 EZH2/PARP1/PARP2 3 GO:0032602 chemokine production 3/436 99/18722 0.406574198620262 0.739245403002712 HMGB1/GSTP1/SUZ12 3 GO:0051153 regulation of striated muscle cell differentiation 3/436 99/18722 0.406574198620262 0.739245403002712 EZH2/PARP2/YBX1 3 GO:0042326 negative regulation of phosphorylation 10/436 385/18722 0.407958165088169 0.740066786625244 PBK/CALM2/PRKDC/NUP62/PPIA/CDKN2A/GSTP1/SUZ12/CTDSPL/BAX 10 GO:0002712 regulation of B cell mediated immunity 2/436 60/18722 0.409053739556018 0.740066786625244 MSH2/RIF1 2 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 2/436 60/18722 0.409053739556018 0.740066786625244 C1QBP/PHB2 2 GO:0002889 regulation of immunoglobulin mediated immune response 2/436 60/18722 0.409053739556018 0.740066786625244 MSH2/RIF1 2 GO:0031102 neuron projection regeneration 2/436 60/18722 0.409053739556018 0.740066786625244 DHFR/NREP 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/436 60/18722 0.409053739556018 0.740066786625244 SLC25A1/MPC2 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/436 60/18722 0.409053739556018 0.740066786625244 SLC25A1/MPC2 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/436 60/18722 0.409053739556018 0.740066786625244 SLC25A1/MPC2 2 GO:0010721 negative regulation of cell development 5/436 180/18722 0.4091829478951 0.740066786625244 YWHAH/ID1/IDH2/TACSTD2/DYNLT1 5 GO:0048660 regulation of smooth muscle cell proliferation 5/436 180/18722 0.4091829478951 0.740066786625244 PRKDC/JUN/XRCC5/GSTP1/XRCC6 5 GO:0032103 positive regulation of response to external stimulus 11/436 427/18722 0.409746754734778 0.740696056635944 HMGB2/HMGB1/PRKDC/CADM1/HSP90AA1/XRCC5/DDT/CD81/C1QBP/XRCC6/HSPD1 11 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 6/436 221/18722 0.410182134837633 0.740854777901375 PBK/NUDT15/SVIP/PSMC3/RPS7/GPX1 6 GO:0010466 negative regulation of peptidase activity 7/436 262/18722 0.410266417374705 0.740854777901375 BIRC5/DHCR24/BCL2L12/PEBP1/SPINT2/APLP2/GPX1 7 GO:0015748 organophosphate ester transport 4/436 140/18722 0.411757642934512 0.742765758626872 SLC29A1/SLC25A5/DBI/SLC25A6 4 GO:0050768 negative regulation of neurogenesis 4/436 140/18722 0.411757642934512 0.742765758626872 YWHAH/ID1/IDH2/DYNLT1 4 GO:0016571 histone methylation 4/436 141/18722 0.416995370318267 0.744892650203745 BRCA1/EZH2/SUZ12/RIF1 4 GO:0019748 secondary metabolic process 2/436 61/18722 0.417171963121435 0.744892650203745 AKR7A2/DDT 2 GO:0001919 regulation of receptor recycling 1/436 23/18722 0.418581471755412 0.744892650203745 NSG1 1 GO:0002052 positive regulation of neuroblast proliferation 1/436 23/18722 0.418581471755412 0.744892650203745 ASPM 1 GO:0006541 glutamine metabolic process 1/436 23/18722 0.418581471755412 0.744892650203745 GMPS 1 GO:0006622 protein targeting to lysosome 1/436 23/18722 0.418581471755412 0.744892650203745 HSPA8 1 GO:0007130 synaptonemal complex assembly 1/436 23/18722 0.418581471755412 0.744892650203745 RAD21 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/436 23/18722 0.418581471755412 0.744892650203745 GSTP1 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/436 23/18722 0.418581471755412 0.744892650203745 CLDN7 1 GO:0021544 subpallium development 1/436 23/18722 0.418581471755412 0.744892650203745 CNTNAP2 1 GO:0030194 positive regulation of blood coagulation 1/436 23/18722 0.418581471755412 0.744892650203745 PRDX2 1 GO:0030325 adrenal gland development 1/436 23/18722 0.418581471755412 0.744892650203745 LY6E 1 GO:0030539 male genitalia development 1/436 23/18722 0.418581471755412 0.744892650203745 DHCR24 1 GO:0035812 renal sodium excretion 1/436 23/18722 0.418581471755412 0.744892650203745 SNX5 1 GO:0042438 melanin biosynthetic process 1/436 23/18722 0.418581471755412 0.744892650203745 DDT 1 GO:0045662 negative regulation of myoblast differentiation 1/436 23/18722 0.418581471755412 0.744892650203745 ID3 1 GO:0045980 negative regulation of nucleotide metabolic process 1/436 23/18722 0.418581471755412 0.744892650203745 PARP1 1 GO:0050765 negative regulation of phagocytosis 1/436 23/18722 0.418581471755412 0.744892650203745 HMGB1 1 GO:0051446 positive regulation of meiotic cell cycle 1/436 23/18722 0.418581471755412 0.744892650203745 RAD51AP1 1 GO:0051457 maintenance of protein location in nucleus 1/436 23/18722 0.418581471755412 0.744892650203745 BARD1 1 GO:0051882 mitochondrial depolarization 1/436 23/18722 0.418581471755412 0.744892650203745 PARP1 1 GO:0060575 intestinal epithelial cell differentiation 1/436 23/18722 0.418581471755412 0.744892650203745 TYMS 1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 1/436 23/18722 0.418581471755412 0.744892650203745 PARP2 1 GO:0071218 cellular response to misfolded protein 1/436 23/18722 0.418581471755412 0.744892650203745 SDF2L1 1 GO:0071514 genetic imprinting 1/436 23/18722 0.418581471755412 0.744892650203745 BRCA1 1 GO:1900048 positive regulation of hemostasis 1/436 23/18722 0.418581471755412 0.744892650203745 PRDX2 1 GO:0042102 positive regulation of T cell proliferation 3/436 101/18722 0.419052357150329 0.745344031821036 HMGB1/CD81/RPS3 3 GO:0030522 intracellular receptor signaling pathway 7/436 265/18722 0.421685131699489 0.749638179720698 BRCA1/EZH2/YWHAH/PARP1/C1QBP/PTGES3/PHB2 7 GO:0002819 regulation of adaptive immune response 5/436 183/18722 0.422975642386174 0.750337240626588 HMGB1/MSH2/CD81/RIF1/HSPD1 5 GO:0002260 lymphocyte homeostasis 2/436 62/18722 0.425233537632035 0.750337240626588 CCNB2/BAX 2 GO:0031124 mRNA 3'-end processing 2/436 62/18722 0.425233537632035 0.750337240626588 BARD1/SLBP 2 GO:0032613 interleukin-10 production 2/436 62/18722 0.425233537632035 0.750337240626588 HMGB1/HSPD1 2 GO:0032653 regulation of interleukin-10 production 2/436 62/18722 0.425233537632035 0.750337240626588 HMGB1/HSPD1 2 GO:0070265 necrotic cell death 2/436 62/18722 0.425233537632035 0.750337240626588 PPIF/BAX 2 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 2/436 62/18722 0.425233537632035 0.750337240626588 NSG1/HRAS 2 GO:0001841 neural tube formation 3/436 102/18722 0.425259135556148 0.750337240626588 KIF20B/RPS7/SPINT2 3 GO:0010522 regulation of calcium ion transport into cytosol 3/436 102/18722 0.425259135556148 0.750337240626588 CALM2/BAX/GSTO1 3 GO:0014897 striated muscle hypertrophy 3/436 102/18722 0.425259135556148 0.750337240626588 EZH2/PARP1/PARP2 3 GO:0062014 negative regulation of small molecule metabolic process 3/436 102/18722 0.425259135556148 0.750337240626588 BRCA1/PGP/PARP1 3 GO:1902106 negative regulation of leukocyte differentiation 3/436 102/18722 0.425259135556148 0.750337240626588 HMGB1/PRDX2/NME1 3 GO:0034284 response to monosaccharide 6/436 225/18722 0.426760225825562 0.750337240626588 SLC29A1/GSTP1/CTSV/NME1/MPC2/LDHA 6 GO:0034763 negative regulation of transmembrane transport 4/436 143/18722 0.427438365754134 0.750337240626588 CALM2/PPIF/VDAC1/GSTO1 4 GO:0048659 smooth muscle cell proliferation 5/436 184/18722 0.427560904485829 0.750337240626588 PRKDC/JUN/XRCC5/GSTP1/XRCC6 5 GO:0032412 regulation of ion transmembrane transporter activity 7/436 267/18722 0.429286465039229 0.750337240626588 YWHAH/CALM2/PPIF/ATP1B3/GSTO1/NDUFA4/PHB2 7 GO:0002703 regulation of leukocyte mediated immunity 6/436 226/18722 0.430894962547935 0.750337240626588 HMGB1/MSH2/CADM1/CD81/RIF1/HSPD1 6 GO:0051495 positive regulation of cytoskeleton organization 6/436 226/18722 0.430894962547935 0.750337240626588 ID1/NUP62/CENPJ/ARPC5L/HRAS/RPS3 6 GO:0030593 neutrophil chemotaxis 3/436 103/18722 0.431442826879669 0.750337240626588 CKLF/PPIA/C1QBP 3 GO:0032760 positive regulation of tumor necrosis factor production 3/436 103/18722 0.431442826879669 0.750337240626588 HMGB1/DDT/HSPD1 3 GO:0050773 regulation of dendrite development 3/436 103/18722 0.431442826879669 0.750337240626588 EZH2/YWHAH/ID1 3 GO:0000395 mRNA 5'-splice site recognition 1/436 24/18722 0.432138265076694 0.750337240626588 PSIP1 1 GO:0002726 positive regulation of T cell cytokine production 1/436 24/18722 0.432138265076694 0.750337240626588 CD81 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/436 24/18722 0.432138265076694 0.750337240626588 HSPD1 1 GO:0006582 melanin metabolic process 1/436 24/18722 0.432138265076694 0.750337240626588 DDT 1 GO:0006817 phosphate ion transport 1/436 24/18722 0.432138265076694 0.750337240626588 SLC20A1 1 GO:0010288 response to lead ion 1/436 24/18722 0.432138265076694 0.750337240626588 CDK4 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/436 24/18722 0.432138265076694 0.750337240626588 ZDHHC12 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/436 24/18722 0.432138265076694 0.750337240626588 ZDHHC12 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/436 24/18722 0.432138265076694 0.750337240626588 ENO1 1 GO:0030859 polarized epithelial cell differentiation 1/436 24/18722 0.432138265076694 0.750337240626588 FAT1 1 GO:0032928 regulation of superoxide anion generation 1/436 24/18722 0.432138265076694 0.750337240626588 GSTP1 1 GO:0033032 regulation of myeloid cell apoptotic process 1/436 24/18722 0.432138265076694 0.750337240626588 CDKN2A 1 GO:0036010 protein localization to endosome 1/436 24/18722 0.432138265076694 0.750337240626588 RDX 1 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/436 24/18722 0.432138265076694 0.750337240626588 C1QBP 1 GO:0044062 regulation of excretion 1/436 24/18722 0.432138265076694 0.750337240626588 SNX5 1 GO:0050687 negative regulation of defense response to virus 1/436 24/18722 0.432138265076694 0.750337240626588 C1QBP 1 GO:0050820 positive regulation of coagulation 1/436 24/18722 0.432138265076694 0.750337240626588 PRDX2 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/436 24/18722 0.432138265076694 0.750337240626588 DHFR 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/436 24/18722 0.432138265076694 0.750337240626588 HMGB1 1 GO:0051156 glucose 6-phosphate metabolic process 1/436 24/18722 0.432138265076694 0.750337240626588 PGAM1 1 GO:0060561 apoptotic process involved in morphogenesis 1/436 24/18722 0.432138265076694 0.750337240626588 BAX 1 GO:0061162 establishment of monopolar cell polarity 1/436 24/18722 0.432138265076694 0.750337240626588 FAT1 1 GO:0090023 positive regulation of neutrophil chemotaxis 1/436 24/18722 0.432138265076694 0.750337240626588 C1QBP 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/436 24/18722 0.432138265076694 0.750337240626588 ENO1 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/436 24/18722 0.432138265076694 0.750337240626588 PARP1 1 GO:0051348 negative regulation of transferase activity 7/436 268/18722 0.433082785884007 0.751104146874464 MAD2L1/FBXO5/NUP62/PPIA/CDKN2A/GSTP1/RPS7 7 GO:0016239 positive regulation of macroautophagy 2/436 63/18722 0.43323669678361 0.751104146874464 SLC25A5/VDAC1 2 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 2/436 63/18722 0.43323669678361 0.751104146874464 BAX/ERP29 2 GO:0120032 regulation of plasma membrane bounded cell projection assembly 5/436 186/18722 0.436709646129699 0.756360825780413 ANLN/HRAS/TACSTD2/VDAC3/RDX 5 GO:1902115 regulation of organelle assembly 5/436 186/18722 0.436709646129699 0.756360825780413 BRCA1/NUP62/CENPJ/VDAC3/RDX 5 GO:0014896 muscle hypertrophy 3/436 104/18722 0.437602313102453 0.757524488523973 EZH2/PARP1/PARP2 3 GO:0051961 negative regulation of nervous system development 4/436 145/18722 0.43783293835654 0.75754150857352 YWHAH/ID1/IDH2/DYNLT1 4 GO:0006066 alcohol metabolic process 9/436 353/18722 0.438848669324722 0.758916222002581 DHFR/PGP/IMPA2/FDPS/DHCR24/AKR7A2/IDH2/SQLE/TPI1 9 GO:0001885 endothelial cell development 2/436 64/18722 0.44117978682479 0.75911457248193 RDX/GPX1 2 GO:0030888 regulation of B cell proliferation 2/436 64/18722 0.44117978682479 0.75911457248193 CD81/SLC39A10 2 GO:0046579 positive regulation of Ras protein signal transduction 2/436 64/18722 0.44117978682479 0.75911457248193 HRAS/DYNLT1 2 GO:0048857 neural nucleus development 2/436 64/18722 0.44117978682479 0.75911457248193 YWHAH/CALM2 2 GO:1900076 regulation of cellular response to insulin stimulus 2/436 64/18722 0.44117978682479 0.75911457248193 NUCKS1/SNX5 2 GO:0061136 regulation of proteasomal protein catabolic process 5/436 187/18722 0.441272046475314 0.75911457248193 PBK/NUDT15/SVIP/PSMC3/GPX1 5 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 1/436 25/18722 0.445379666104962 0.75911457248193 EMP2 1 GO:0003094 glomerular filtration 1/436 25/18722 0.445379666104962 0.75911457248193 EMP2 1 GO:0010954 positive regulation of protein processing 1/436 25/18722 0.445379666104962 0.75911457248193 ENO1 1 GO:0010996 response to auditory stimulus 1/436 25/18722 0.445379666104962 0.75911457248193 CNTNAP2 1 GO:0016540 protein autoprocessing 1/436 25/18722 0.445379666104962 0.75911457248193 PARP1 1 GO:0021846 cell proliferation in forebrain 1/436 25/18722 0.445379666104962 0.75911457248193 RRM1 1 GO:0031579 membrane raft organization 1/436 25/18722 0.445379666104962 0.75911457248193 EMP2 1 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1/436 25/18722 0.445379666104962 0.75911457248193 PRDX2 1 GO:0032331 negative regulation of chondrocyte differentiation 1/436 25/18722 0.445379666104962 0.75911457248193 EFEMP1 1 GO:0032469 endoplasmic reticulum calcium ion homeostasis 1/436 25/18722 0.445379666104962 0.75911457248193 BAX 1 GO:0032878 regulation of establishment or maintenance of cell polarity 1/436 25/18722 0.445379666104962 0.75911457248193 KIF20B 1 GO:0033233 regulation of protein sumoylation 1/436 25/18722 0.445379666104962 0.75911457248193 SAE1 1 GO:0042832 defense response to protozoan 1/436 25/18722 0.445379666104962 0.75911457248193 HRAS 1 GO:0044550 secondary metabolite biosynthetic process 1/436 25/18722 0.445379666104962 0.75911457248193 DDT 1 GO:0046949 fatty-acyl-CoA biosynthetic process 1/436 25/18722 0.445379666104962 0.75911457248193 SLC25A1 1 GO:0051450 myoblast proliferation 1/436 25/18722 0.445379666104962 0.75911457248193 GPX1 1 GO:0051788 response to misfolded protein 1/436 25/18722 0.445379666104962 0.75911457248193 SDF2L1 1 GO:0060706 cell differentiation involved in embryonic placenta development 1/436 25/18722 0.445379666104962 0.75911457248193 SPINT2 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/436 25/18722 0.445379666104962 0.75911457248193 FAT1 1 GO:0061436 establishment of skin barrier 1/436 25/18722 0.445379666104962 0.75911457248193 STMN1 1 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 1/436 25/18722 0.445379666104962 0.75911457248193 CALM2 1 GO:1904385 cellular response to angiotensin 1/436 25/18722 0.445379666104962 0.75911457248193 CDC6 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/436 25/18722 0.445379666104962 0.75911457248193 HMGB1 1 GO:0060491 regulation of cell projection assembly 5/436 188/18722 0.445825761607448 0.759497610762242 ANLN/HRAS/TACSTD2/VDAC3/RDX 5 GO:1902652 secondary alcohol metabolic process 4/436 147/18722 0.448173146005965 0.761982784832325 FDPS/DHCR24/IDH2/SQLE 4 GO:1903531 negative regulation of secretion by cell 4/436 147/18722 0.448173146005965 0.761982784832325 HADH/PNKD/IDH2/ERP29 4 GO:0006605 protein targeting 8/436 314/18722 0.448644916082999 0.761982784832325 SAE1/ZDHHC12/TOMM40/HSP90AA1/HSPA8/HRAS/HSPD1/LMAN1 8 GO:0038034 signal transduction in absence of ligand 2/436 65/18722 0.449061262294072 0.761982784832325 PRDX2/BAX 2 GO:0070613 regulation of protein processing 2/436 65/18722 0.449061262294072 0.761982784832325 BCL2L12/ENO1 2 GO:0071677 positive regulation of mononuclear cell migration 2/436 65/18722 0.449061262294072 0.761982784832325 HMGB1/C1QBP 2 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 2/436 65/18722 0.449061262294072 0.761982784832325 PRDX2/BAX 2 GO:1905330 regulation of morphogenesis of an epithelium 2/436 65/18722 0.449061262294072 0.761982784832325 TACSTD2/PHB2 2 GO:0030038 contractile actin filament bundle assembly 3/436 106/18722 0.4498443824269 0.762180778324293 STMN1/TACSTD2/PDLIM1 3 GO:0043149 stress fiber assembly 3/436 106/18722 0.4498443824269 0.762180778324293 STMN1/TACSTD2/PDLIM1 3 GO:1903707 negative regulation of hemopoiesis 3/436 106/18722 0.4498443824269 0.762180778324293 HMGB1/PRDX2/NME1 3 GO:0045732 positive regulation of protein catabolic process 6/436 231/18722 0.451489192704963 0.764590039570942 DTL/BARD1/HSP90AA1/PSMC3/CD81/RDX 6 GO:1904062 regulation of cation transmembrane transport 9/436 357/18722 0.452075159327157 0.764676547433198 YWHAH/CALM2/PPIF/ATP1B3/BAX/VDAC1/GSTO1/NDUFA4/PHB2 9 GO:0014074 response to purine-containing compound 4/436 148/18722 0.453321077937821 0.764676547433198 JUN/NME1/LDHA/HSPD1 4 GO:0044272 sulfur compound biosynthetic process 4/436 148/18722 0.453321077937821 0.764676547433198 MTAP/SLC25A1/GSTP1/MPC2 4 GO:0050905 neuromuscular process 4/436 148/18722 0.453321077937821 0.764676547433198 PNKD/IGDCC3/C12orf57/GSTO1 4 GO:0009755 hormone-mediated signaling pathway 5/436 190/18722 0.454905074378396 0.764676547433198 BRCA1/YWHAH/PARP1/PTGES3/PHB2 5 GO:0032526 response to retinoic acid 3/436 107/18722 0.455924912319526 0.764676547433198 SUZ12/PHB2/CTSH 3 GO:0051341 regulation of oxidoreductase activity 3/436 107/18722 0.455924912319526 0.764676547433198 DHFR/NDUFA4/PHB2 3 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 3/436 107/18722 0.455924912319526 0.764676547433198 HMGB1/DDT/HSPD1 3 GO:0050918 positive chemotaxis 2/436 66/18722 0.456879681893609 0.764676547433198 HMGB2/HMGB1 2 GO:0050922 negative regulation of chemotaxis 2/436 66/18722 0.456879681893609 0.764676547433198 DDT/GSTP1 2 GO:2000272 negative regulation of signaling receptor activity 2/436 66/18722 0.456879681893609 0.764676547433198 LY6E/LRPAP1 2 GO:0001562 response to protozoan 1/436 26/18722 0.458312995814447 0.764676547433198 HRAS 1 GO:0001963 synaptic transmission, dopaminergic 1/436 26/18722 0.458312995814447 0.764676547433198 PNKD 1 GO:0006706 steroid catabolic process 1/436 26/18722 0.458312995814447 0.764676547433198 YWHAH 1 GO:0008535 respiratory chain complex IV assembly 1/436 26/18722 0.458312995814447 0.764676547433198 COX14 1 GO:0009164 nucleoside catabolic process 1/436 26/18722 0.458312995814447 0.764676547433198 NUDT1 1 GO:0021952 central nervous system projection neuron axonogenesis 1/436 26/18722 0.458312995814447 0.764676547433198 C12orf57 1 GO:0032515 negative regulation of phosphoprotein phosphatase activity 1/436 26/18722 0.458312995814447 0.764676547433198 MASTL 1 GO:0043094 cellular metabolic compound salvage 1/436 26/18722 0.458312995814447 0.764676547433198 MTAP 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/436 26/18722 0.458312995814447 0.764676547433198 CADM1 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/436 26/18722 0.458312995814447 0.764676547433198 HMGB1 1 GO:0046697 decidualization 1/436 26/18722 0.458312995814447 0.764676547433198 CTSV 1 GO:0051016 barbed-end actin filament capping 1/436 26/18722 0.458312995814447 0.764676547433198 RDX 1 GO:0060352 cell adhesion molecule production 1/436 26/18722 0.458312995814447 0.764676547433198 PPIA 1 GO:0060669 embryonic placenta morphogenesis 1/436 26/18722 0.458312995814447 0.764676547433198 SPINT2 1 GO:0070193 synaptonemal complex organization 1/436 26/18722 0.458312995814447 0.764676547433198 RAD21 1 GO:0097186 amelogenesis 1/436 26/18722 0.458312995814447 0.764676547433198 PERP 1 GO:0097205 renal filtration 1/436 26/18722 0.458312995814447 0.764676547433198 EMP2 1 GO:0099637 neurotransmitter receptor transport 1/436 26/18722 0.458312995814447 0.764676547433198 NSG1 1 GO:1904861 excitatory synapse assembly 1/436 26/18722 0.458312995814447 0.764676547433198 ZDHHC12 1 GO:0009306 protein secretion 9/436 359/18722 0.458672204785054 0.764676547433198 HADH/PPIA/UQCC2/IDH2/DNAJC1/MYH10/MPC2/WLS/ERP29 9 GO:1901653 cellular response to peptide 9/436 359/18722 0.458672204785054 0.764676547433198 CDC6/CCNA2/ID1/PRKDC/PARP1/CDK4/NUCKS1/GSTP1/SNX5 9 GO:0002366 leukocyte activation involved in immune response 7/436 275/18722 0.459545701530581 0.765760710029831 UNG/HMGB1/MSH2/MSH6/CD81/RIF1/HSPD1 7 GO:0035592 establishment of protein localization to extracellular region 9/436 360/18722 0.461965930880887 0.769065275131559 HADH/PPIA/UQCC2/IDH2/DNAJC1/MYH10/MPC2/WLS/ERP29 9 GO:0007173 epidermal growth factor receptor signaling pathway 3/436 108/18722 0.461977129713245 0.769065275131559 NUP62/SNX5/EFEMP1 3 GO:0070665 positive regulation of leukocyte proliferation 4/436 150/18722 0.46356917119269 0.770496974444084 HMGB1/CD81/RPS3/SLC39A10 4 GO:0006513 protein monoubiquitination 2/436 67/18722 0.464633704495718 0.770496974444084 DTL/UBE2T 2 GO:0010517 regulation of phospholipase activity 2/436 67/18722 0.464633704495718 0.770496974444084 HRAS/PHB2 2 GO:0048814 regulation of dendrite morphogenesis 2/436 67/18722 0.464633704495718 0.770496974444084 YWHAH/ID1 2 GO:0072665 protein localization to vacuole 2/436 67/18722 0.464633704495718 0.770496974444084 HSPA8/CD81 2 GO:1902117 positive regulation of organelle assembly 2/436 67/18722 0.464633704495718 0.770496974444084 NUP62/CENPJ 2 GO:1903317 regulation of protein maturation 2/436 67/18722 0.464633704495718 0.770496974444084 BCL2L12/ENO1 2 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 2/436 67/18722 0.464633704495718 0.770496974444084 HMGB1/CD81 2 GO:0002699 positive regulation of immune effector process 6/436 235/18722 0.467845444784213 0.770903476479305 MSH2/CADM1/CD81/RIF1/HSPD1/PHB2 6 GO:0032410 negative regulation of transporter activity 3/436 109/18722 0.468000096479485 0.770903476479305 CALM2/PPIF/GSTO1 3 GO:0051251 positive regulation of lymphocyte activation 9/436 362/18722 0.468542743150771 0.770903476479305 HMGB1/MSH2/PRKDC/CD81/RPS3/RIF1/SLC39A10/XRCC6/HSPD1 9 GO:0030902 hindbrain development 4/436 151/18722 0.468668010670251 0.770903476479305 EZH2/PSMG1/HNRNPD/WLS 4 GO:1904064 positive regulation of cation transmembrane transport 4/436 151/18722 0.468668010670251 0.770903476479305 CALM2/ATP1B3/BAX/GSTO1 4 GO:0007281 germ cell development 7/436 278/18722 0.470810121080417 0.770903476479305 HMGB2/FBXO5/MSH2/BRCA2/ASPM/SRPK1/BAX 7 GO:0022898 regulation of transmembrane transporter activity 7/436 278/18722 0.470810121080417 0.770903476479305 YWHAH/CALM2/PPIF/ATP1B3/GSTO1/NDUFA4/PHB2 7 GO:0000027 ribosomal large subunit assembly 1/436 27/18722 0.470945405625364 0.770903476479305 RPL3 1 GO:0000737 DNA catabolic process, endonucleolytic 1/436 27/18722 0.470945405625364 0.770903476479305 BAX 1 GO:0001835 blastocyst hatching 1/436 27/18722 0.470945405625364 0.770903476479305 ASF1B 1 GO:0008053 mitochondrial fusion 1/436 27/18722 0.470945405625364 0.770903476479305 BAX 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/436 27/18722 0.470945405625364 0.770903476479305 ITM2C 1 GO:0010586 miRNA metabolic process 1/436 27/18722 0.470945405625364 0.770903476479305 HRAS 1 GO:0010758 regulation of macrophage chemotaxis 1/436 27/18722 0.470945405625364 0.770903476479305 DDT 1 GO:0018126 protein hydroxylation 1/436 27/18722 0.470945405625364 0.770903476479305 PRDX4 1 GO:0018904 ether metabolic process 1/436 27/18722 0.470945405625364 0.770903476479305 CHPT1 1 GO:0031954 positive regulation of protein autophosphorylation 1/436 27/18722 0.470945405625364 0.770903476479305 CALM2 1 GO:0033561 regulation of water loss via skin 1/436 27/18722 0.470945405625364 0.770903476479305 STMN1 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/436 27/18722 0.470945405625364 0.770903476479305 HMGB1 1 GO:0035188 hatching 1/436 27/18722 0.470945405625364 0.770903476479305 ASF1B 1 GO:0071624 positive regulation of granulocyte chemotaxis 1/436 27/18722 0.470945405625364 0.770903476479305 C1QBP 1 GO:0071684 organism emergence from protective structure 1/436 27/18722 0.470945405625364 0.770903476479305 ASF1B 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/436 27/18722 0.470945405625364 0.770903476479305 ATP1B3 1 GO:1902914 regulation of protein polyubiquitination 1/436 27/18722 0.470945405625364 0.770903476479305 PPIA 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/436 27/18722 0.470945405625364 0.770903476479305 PARP1 1 GO:1903319 positive regulation of protein maturation 1/436 27/18722 0.470945405625364 0.770903476479305 ENO1 1 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 1/436 27/18722 0.470945405625364 0.770903476479305 PARP1 1 GO:0009988 cell-cell recognition 2/436 68/18722 0.472322085278199 0.770950083058753 CD81/CCT5 2 GO:0010812 negative regulation of cell-substrate adhesion 2/436 68/18722 0.472322085278199 0.770950083058753 CDKN2A/TACSTD2 2 GO:0051148 negative regulation of muscle cell differentiation 2/436 68/18722 0.472322085278199 0.770950083058753 EZH2/YBX1 2 GO:1901607 alpha-amino acid biosynthetic process 2/436 68/18722 0.472322085278199 0.770950083058753 DHFR/MTAP 2 GO:1902305 regulation of sodium ion transmembrane transport 2/436 68/18722 0.472322085278199 0.770950083058753 YWHAH/ATP1B3 2 GO:1904888 cranial skeletal system development 2/436 68/18722 0.472322085278199 0.770950083058753 TMEM107/SLC39A1 2 GO:0021915 neural tube development 4/436 152/18722 0.473749191165926 0.772207820819543 KIF20B/TMEM107/RPS7/SPINT2 4 GO:0050871 positive regulation of B cell activation 4/436 152/18722 0.473749191165926 0.772207820819543 MSH2/CD81/RIF1/SLC39A10 4 GO:0009408 response to heat 3/436 110/18722 0.473992908961223 0.772207820819543 PSIP1/HSP90AA1/HSPD1 3 GO:0018958 phenol-containing compound metabolic process 3/436 110/18722 0.473992908961223 0.772207820819543 PNKD/DDT/LY6E 3 GO:0002263 cell activation involved in immune response 7/436 279/18722 0.474552469614091 0.772752502727074 UNG/HMGB1/MSH2/MSH6/CD81/RIF1/HSPD1 7 GO:0050767 regulation of neurogenesis 9/436 364/18722 0.475103994842913 0.773283589329239 HMGB2/EZH2/YWHAH/ID1/ASPM/NAP1L1/XRCC5/IDH2/DYNLT1 9 GO:0030705 cytoskeleton-dependent intracellular transport 5/436 195/18722 0.477416215313505 0.776678537098452 TUBA1B/TUBB/TUBA1C/HSPB11/HSPA8 5 GO:0010611 regulation of cardiac muscle hypertrophy 2/436 69/18722 0.479943671984633 0.777742493815923 PARP1/PARP2 2 GO:0031060 regulation of histone methylation 2/436 69/18722 0.479943671984633 0.777742493815923 BRCA1/RIF1 2 GO:0034605 cellular response to heat 2/436 69/18722 0.479943671984633 0.777742493815923 HSP90AA1/HSPD1 2 GO:0060193 positive regulation of lipase activity 2/436 69/18722 0.479943671984633 0.777742493815923 HRAS/PHB2 2 GO:0051259 protein complex oligomerization 6/436 238/18722 0.480027223357555 0.777742493815923 RRM2/BLM/RRM1/TK1/FUS/RBMX 6 GO:0006006 glucose metabolic process 5/436 196/18722 0.481882559138676 0.777742493815923 HMGB1/PGP/SLC25A1/ENO1/TPI1 5 GO:0043393 regulation of protein binding 5/436 196/18722 0.481882559138676 0.777742493815923 AURKB/ID1/RAN/BAX/LRPAP1 5 GO:0006470 protein dephosphorylation 7/436 281/18722 0.482016739207893 0.777742493815923 MASTL/PGP/CALM2/PPM1G/PPIA/CTDSPL/SLC39A10 7 GO:0002507 tolerance induction 1/436 28/18722 0.483283881321932 0.777742493815923 HMGB1 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/436 28/18722 0.483283881321932 0.777742493815923 SDF2L1 1 GO:0008299 isoprenoid biosynthetic process 1/436 28/18722 0.483283881321932 0.777742493815923 FDPS 1 GO:0010575 positive regulation of vascular endothelial growth factor production 1/436 28/18722 0.483283881321932 0.777742493815923 BRCA1 1 GO:0010884 positive regulation of lipid storage 1/436 28/18722 0.483283881321932 0.777742493815923 HILPDA 1 GO:0031440 regulation of mRNA 3'-end processing 1/436 28/18722 0.483283881321932 0.777742493815923 BARD1 1 GO:0034123 positive regulation of toll-like receptor signaling pathway 1/436 28/18722 0.483283881321932 0.777742493815923 HMGB1 1 GO:0042983 amyloid precursor protein biosynthetic process 1/436 28/18722 0.483283881321932 0.777742493815923 ITM2C 1 GO:0042984 regulation of amyloid precursor protein biosynthetic process 1/436 28/18722 0.483283881321932 0.777742493815923 ITM2C 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/436 28/18722 0.483283881321932 0.777742493815923 SUZ12 1 GO:0071280 cellular response to copper ion 1/436 28/18722 0.483283881321932 0.777742493815923 MT2A 1 GO:1902624 positive regulation of neutrophil migration 1/436 28/18722 0.483283881321932 0.777742493815923 C1QBP 1 GO:1903649 regulation of cytoplasmic transport 1/436 28/18722 0.483283881321932 0.777742493815923 RDX 1 GO:1903672 positive regulation of sprouting angiogenesis 1/436 28/18722 0.483283881321932 0.777742493815923 HMGB1 1 GO:1990776 response to angiotensin 1/436 28/18722 0.483283881321932 0.777742493815923 CDC6 1 GO:0010633 negative regulation of epithelial cell migration 3/436 112/18722 0.485884625647956 0.781195009652361 HMGB1/MARVELD3/TACSTD2 3 GO:1901222 regulation of NIK/NF-kappaB signaling 3/436 112/18722 0.485884625647956 0.781195009652361 HMGB1/RPS3/PHB2 3 GO:0070830 bicellular tight junction assembly 2/436 70/18722 0.487497401305978 0.783420882379771 MARVELD3/CLDN7 2 GO:0050851 antigen receptor-mediated signaling pathway 6/436 240/18722 0.488102341316409 0.783772948318933 CD81/HRAS/RPS3/BAX/SLC39A10/KHDRBS1 6 GO:0071692 protein localization to extracellular region 9/436 368/18722 0.488173357784191 0.783772948318933 HADH/PPIA/UQCC2/IDH2/DNAJC1/MYH10/MPC2/WLS/ERP29 9 GO:1903364 positive regulation of cellular protein catabolic process 4/436 155/18722 0.488880653708085 0.784541404524059 HSP90AA1/PSMC3/CD81/RDX 4 GO:0044262 cellular carbohydrate metabolic process 7/436 283/18722 0.48945188801065 0.785090896570612 HMGB1/PGP/IMPA2/IDH2/TPI1/PTGES3/PGAM1 7 GO:0033555 multicellular organismal response to stress 2/436 71/18722 0.494982295379846 0.786075500483573 VDAC1/VWA1 2 GO:0043550 regulation of lipid kinase activity 2/436 71/18722 0.494982295379846 0.786075500483573 RBL1/CD81 2 GO:0042098 T cell proliferation 5/436 199/18722 0.495201708813342 0.786075500483573 HMGB1/PRDX2/CD81/RPS3/BAX 5 GO:0001773 myeloid dendritic cell activation 1/436 29/18722 0.49533524688006 0.786075500483573 HMGB1 1 GO:0002360 T cell lineage commitment 1/436 29/18722 0.49533524688006 0.786075500483573 PRKDC 1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 1/436 29/18722 0.49533524688006 0.786075500483573 GPX1 1 GO:0006656 phosphatidylcholine biosynthetic process 1/436 29/18722 0.49533524688006 0.786075500483573 CHPT1 1 GO:0006734 NADH metabolic process 1/436 29/18722 0.49533524688006 0.786075500483573 ENO1 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/436 29/18722 0.49533524688006 0.786075500483573 NME1 1 GO:0010955 negative regulation of protein processing 1/436 29/18722 0.49533524688006 0.786075500483573 BCL2L12 1 GO:0019359 nicotinamide nucleotide biosynthetic process 1/436 29/18722 0.49533524688006 0.786075500483573 IDH2 1 GO:0019363 pyridine nucleotide biosynthetic process 1/436 29/18722 0.49533524688006 0.786075500483573 IDH2 1 GO:0030970 retrograde protein transport, ER to cytosol 1/436 29/18722 0.49533524688006 0.786075500483573 SVIP 1 GO:0033028 myeloid cell apoptotic process 1/436 29/18722 0.49533524688006 0.786075500483573 CDKN2A 1 GO:0034311 diol metabolic process 1/436 29/18722 0.49533524688006 0.786075500483573 DHFR 1 GO:0042759 long-chain fatty acid biosynthetic process 1/436 29/18722 0.49533524688006 0.786075500483573 GSTP1 1 GO:0048265 response to pain 1/436 29/18722 0.49533524688006 0.786075500483573 VWA1 1 GO:0060441 epithelial tube branching involved in lung morphogenesis 1/436 29/18722 0.49533524688006 0.786075500483573 CTSH 1 GO:0090025 regulation of monocyte chemotaxis 1/436 29/18722 0.49533524688006 0.786075500483573 HMGB1 1 GO:0095500 acetylcholine receptor signaling pathway 1/436 29/18722 0.49533524688006 0.786075500483573 LY6E 1 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1/436 29/18722 0.49533524688006 0.786075500483573 RPS7 1 GO:1903318 negative regulation of protein maturation 1/436 29/18722 0.49533524688006 0.786075500483573 BCL2L12 1 GO:1903513 endoplasmic reticulum to cytosol transport 1/436 29/18722 0.49533524688006 0.786075500483573 SVIP 1 GO:0021987 cerebral cortex development 3/436 114/18722 0.497645719848594 0.789377006380271 CNTNAP2/ASPM/BAX 3 GO:1902107 positive regulation of leukocyte differentiation 4/436 157/18722 0.4988690500309 0.790221473063721 HMGB1/PRKDC/JUN/XRCC6 4 GO:1903708 positive regulation of hemopoiesis 4/436 157/18722 0.4988690500309 0.790221473063721 HMGB1/PRKDC/JUN/XRCC6 4 GO:1990845 adaptive thermogenesis 4/436 157/18722 0.4988690500309 0.790221473063721 ID1/HADH/SLC25A5/FH 4 GO:0045216 cell-cell junction organization 5/436 200/18722 0.499613370473412 0.791035290306542 CNTNAP2/MARVELD3/CLDN7/PERP/RDX 5 GO:0005977 glycogen metabolic process 2/436 72/18722 0.502397458403965 0.7936121914291 HMGB1/PTGES3 2 GO:0014743 regulation of muscle hypertrophy 2/436 72/18722 0.502397458403965 0.7936121914291 PARP1/PARP2 2 GO:0032729 positive regulation of interferon-gamma production 2/436 72/18722 0.502397458403965 0.7936121914291 HRAS/HSPD1 2 GO:0051057 positive regulation of small GTPase mediated signal transduction 2/436 72/18722 0.502397458403965 0.7936121914291 HRAS/DYNLT1 2 GO:0055021 regulation of cardiac muscle tissue growth 2/436 72/18722 0.502397458403965 0.7936121914291 CDK1/PARP2 2 GO:0051209 release of sequestered calcium ion into cytosol 3/436 115/18722 0.503475375469108 0.793883365274468 CALM2/BAX/GSTO1 3 GO:0003299 muscle hypertrophy in response to stress 1/436 30/18722 0.507106168206775 0.793883365274468 EZH2 1 GO:0007202 activation of phospholipase C activity 1/436 30/18722 0.507106168206775 0.793883365274468 PHB2 1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 1/436 30/18722 0.507106168206775 0.793883365274468 CALM2 1 GO:0014887 cardiac muscle adaptation 1/436 30/18722 0.507106168206775 0.793883365274468 EZH2 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/436 30/18722 0.507106168206775 0.793883365274468 EZH2 1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 1/436 30/18722 0.507106168206775 0.793883365274468 CTSV 1 GO:0033137 negative regulation of peptidyl-serine phosphorylation 1/436 30/18722 0.507106168206775 0.793883365274468 BAX 1 GO:0034390 smooth muscle cell apoptotic process 1/436 30/18722 0.507106168206775 0.793883365274468 CDKN2A 1 GO:0034391 regulation of smooth muscle cell apoptotic process 1/436 30/18722 0.507106168206775 0.793883365274468 CDKN2A 1 GO:0036296 response to increased oxygen levels 1/436 30/18722 0.507106168206775 0.793883365274468 CDK4 1 GO:0043032 positive regulation of macrophage activation 1/436 30/18722 0.507106168206775 0.793883365274468 HSPD1 1 GO:0045948 positive regulation of translational initiation 1/436 30/18722 0.507106168206775 0.793883365274468 KHDRBS1 1 GO:0060603 mammary gland duct morphogenesis 1/436 30/18722 0.507106168206775 0.793883365274468 PHB2 1 GO:0090314 positive regulation of protein targeting to membrane 1/436 30/18722 0.507106168206775 0.793883365274468 HRAS 1 GO:0099068 postsynapse assembly 1/436 30/18722 0.507106168206775 0.793883365274468 ZDHHC12 1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 1/436 30/18722 0.507106168206775 0.793883365274468 BAX 1 GO:1903019 negative regulation of glycoprotein metabolic process 1/436 30/18722 0.507106168206775 0.793883365274468 ITM2C 1 GO:2000648 positive regulation of stem cell proliferation 1/436 30/18722 0.507106168206775 0.793883365274468 CCNE1 1 GO:0016051 carbohydrate biosynthetic process 5/436 202/18722 0.508392135790239 0.793883365274468 PGP/IMPA2/SLC25A1/TPI1/PTGES3 5 GO:1903169 regulation of calcium ion transmembrane transport 4/436 159/18722 0.508772887566652 0.793883365274468 CALM2/BAX/VDAC1/GSTO1 4 GO:0008286 insulin receptor signaling pathway 3/436 116/18722 0.509270148938332 0.793883365274468 CDK4/NUCKS1/SNX5 3 GO:0033559 unsaturated fatty acid metabolic process 3/436 116/18722 0.509270148938332 0.793883365274468 GSTP1/PTGES3/GPX1 3 GO:0043200 response to amino acid 3/436 116/18722 0.509270148938332 0.793883365274468 PCNA/HNRNPD/GSTP1 3 GO:0051283 negative regulation of sequestering of calcium ion 3/436 116/18722 0.509270148938332 0.793883365274468 CALM2/BAX/GSTO1 3 GO:0006073 cellular glucan metabolic process 2/436 73/18722 0.509742073360435 0.793883365274468 HMGB1/PTGES3 2 GO:0032456 endocytic recycling 2/436 73/18722 0.509742073360435 0.793883365274468 NSG1/VPS29 2 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 2/436 73/18722 0.509742073360435 0.793883365274468 NUP62/SNX5 2 GO:0044042 glucan metabolic process 2/436 73/18722 0.509742073360435 0.793883365274468 HMGB1/PTGES3 2 GO:0051865 protein autoubiquitination 2/436 73/18722 0.509742073360435 0.793883365274468 UBE2T/BRCA1 2 GO:0072089 stem cell proliferation 2/436 73/18722 0.509742073360435 0.793883365274468 HMGB2/CCNE1 2 GO:0071216 cellular response to biotic stimulus 6/436 246/18722 0.51207676223582 0.795763609552002 HMGB2/HMGB1/CDK4/PRDX2/GSTP1/SMC1A 6 GO:0043271 negative regulation of ion transport 4/436 160/18722 0.513691791730628 0.795763609552002 CALM2/PPIF/VDAC1/GSTO1 4 GO:0030968 endoplasmic reticulum unfolded protein response 2/436 74/18722 0.517015398847461 0.795763609552002 CCND1/BAX 2 GO:0046470 phosphatidylcholine metabolic process 2/436 74/18722 0.517015398847461 0.795763609552002 CHPT1/DBI 2 GO:0051881 regulation of mitochondrial membrane potential 2/436 74/18722 0.517015398847461 0.795763609552002 PARP1/BAX 2 GO:0120192 tight junction assembly 2/436 74/18722 0.517015398847461 0.795763609552002 MARVELD3/CLDN7 2 GO:1901568 fatty acid derivative metabolic process 2/436 74/18722 0.517015398847461 0.795763609552002 NUDT8/SLC25A1 2 GO:0001516 prostaglandin biosynthetic process 1/436 31/18722 0.518603156793435 0.795763609552002 PTGES3 1 GO:0001782 B cell homeostasis 1/436 31/18722 0.518603156793435 0.795763609552002 BAX 1 GO:0002230 positive regulation of defense response to virus by host 1/436 31/18722 0.518603156793435 0.795763609552002 HSP90AA1 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/436 31/18722 0.518603156793435 0.795763609552002 CADM1 1 GO:0002828 regulation of type 2 immune response 1/436 31/18722 0.518603156793435 0.795763609552002 CD81 1 GO:0032148 activation of protein kinase B activity 1/436 31/18722 0.518603156793435 0.795763609552002 PPIA 1 GO:0033238 regulation of cellular amine metabolic process 1/436 31/18722 0.518603156793435 0.795763609552002 PNKD 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/436 31/18722 0.518603156793435 0.795763609552002 NUDT1 1 GO:0035510 DNA dealkylation 1/436 31/18722 0.518603156793435 0.795763609552002 MGMT 1 GO:0036475 neuron death in response to oxidative stress 1/436 31/18722 0.518603156793435 0.795763609552002 PARP1 1 GO:0042133 neurotransmitter metabolic process 1/436 31/18722 0.518603156793435 0.795763609552002 GCHFR 1 GO:0043171 peptide catabolic process 1/436 31/18722 0.518603156793435 0.795763609552002 CTSH 1 GO:0046457 prostanoid biosynthetic process 1/436 31/18722 0.518603156793435 0.795763609552002 PTGES3 1 GO:0048384 retinoic acid receptor signaling pathway 1/436 31/18722 0.518603156793435 0.795763609552002 EZH2 1 GO:0051569 regulation of histone H3-K4 methylation 1/436 31/18722 0.518603156793435 0.795763609552002 BRCA1 1 GO:0055075 potassium ion homeostasis 1/436 31/18722 0.518603156793435 0.795763609552002 ATP1B3 1 GO:0060045 positive regulation of cardiac muscle cell proliferation 1/436 31/18722 0.518603156793435 0.795763609552002 CDK1 1 GO:0060055 angiogenesis involved in wound healing 1/436 31/18722 0.518603156793435 0.795763609552002 GPX1 1 GO:0060390 regulation of SMAD protein signal transduction 1/436 31/18722 0.518603156793435 0.795763609552002 PARP1 1 GO:0071711 basement membrane organization 1/436 31/18722 0.518603156793435 0.795763609552002 SPINT2 1 GO:0090162 establishment of epithelial cell polarity 1/436 31/18722 0.518603156793435 0.795763609552002 FAT1 1 GO:0090183 regulation of kidney development 1/436 31/18722 0.518603156793435 0.795763609552002 TACSTD2 1 GO:0097106 postsynaptic density organization 1/436 31/18722 0.518603156793435 0.795763609552002 ZDHHC12 1 GO:1905144 response to acetylcholine 1/436 31/18722 0.518603156793435 0.795763609552002 LY6E 1 GO:1905145 cellular response to acetylcholine 1/436 31/18722 0.518603156793435 0.795763609552002 LY6E 1 GO:2000144 positive regulation of DNA-templated transcription, initiation 1/436 31/18722 0.518603156793435 0.795763609552002 JUN 1 GO:0021537 telencephalon development 6/436 248/18722 0.519976049772502 0.797157205884475 EZH2/CNTNAP2/ASPM/NME1/BAX/C12orf57 6 GO:0033002 muscle cell proliferation 6/436 248/18722 0.519976049772502 0.797157205884475 CDK1/PRKDC/JUN/XRCC5/GSTP1/XRCC6 6 GO:0045446 endothelial cell differentiation 3/436 118/18722 0.520752369986161 0.79763454527791 ID1/RDX/GPX1 3 GO:0051282 regulation of sequestering of calcium ion 3/436 118/18722 0.520752369986161 0.79763454527791 CALM2/BAX/GSTO1 3 GO:0050878 regulation of body fluid levels 9/436 379/18722 0.523658803032647 0.801728403929054 STMN1/SLC29A1/PPIA/EMP2/VKORC1/PRDX2/NME1/CCND1/LMAN1 9 GO:2001259 positive regulation of cation channel activity 2/436 75/18722 0.524216766015361 0.802224676270608 CALM2/GSTO1 2 GO:0001819 positive regulation of cytokine production 11/436 467/18722 0.527735576612615 0.80507332105393 BRCA1/HMGB2/HMGB1/CADM1/HSP90AA1/DDT/CD81/HRAS/HILPDA/RPS3/HSPD1 11 GO:0006633 fatty acid biosynthetic process 4/436 163/18722 0.528310548224251 0.80507332105393 BRCA1/HACD3/GSTP1/PTGES3 4 GO:0006308 DNA catabolic process 1/436 32/18722 0.529832573284691 0.80507332105393 BAX 1 GO:0006506 GPI anchor biosynthetic process 1/436 32/18722 0.529832573284691 0.80507332105393 PGAP2 1 GO:0010039 response to iron ion 1/436 32/18722 0.529832573284691 0.80507332105393 CCND1 1 GO:0010644 cell communication by electrical coupling 1/436 32/18722 0.529832573284691 0.80507332105393 CALM2 1 GO:0030431 sleep 1/436 32/18722 0.529832573284691 0.80507332105393 SLC29A1 1 GO:0035767 endothelial cell chemotaxis 1/436 32/18722 0.529832573284691 0.80507332105393 HMGB1 1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1/436 32/18722 0.529832573284691 0.80507332105393 CDKN2A 1 GO:0061037 negative regulation of cartilage development 1/436 32/18722 0.529832573284691 0.80507332105393 EFEMP1 1 GO:0072525 pyridine-containing compound biosynthetic process 1/436 32/18722 0.529832573284691 0.80507332105393 IDH2 1 GO:0090022 regulation of neutrophil chemotaxis 1/436 32/18722 0.529832573284691 0.80507332105393 C1QBP 1 GO:1901532 regulation of hematopoietic progenitor cell differentiation 1/436 32/18722 0.529832573284691 0.80507332105393 PRKDC 1 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/436 32/18722 0.529832573284691 0.80507332105393 ERP29 1 GO:1903955 positive regulation of protein targeting to mitochondrion 1/436 32/18722 0.529832573284691 0.80507332105393 SAE1 1 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 1/436 32/18722 0.529832573284691 0.80507332105393 HMGB1 1 GO:0002764 immune response-regulating signaling pathway 11/436 468/18722 0.530610102472386 0.80558845333468 HMGB1/CD81/HRAS/RPS3/BAX/SLC39A10/C1QBP/HSPD1/KHDRBS1/PHB2/CTSH 11 GO:0006809 nitric oxide biosynthetic process 2/436 76/18722 0.531345575603725 0.80558845333468 GCHFR/HSP90AA1 2 GO:0008652 cellular amino acid biosynthetic process 2/436 76/18722 0.531345575603725 0.80558845333468 DHFR/MTAP 2 GO:0021536 diencephalon development 2/436 76/18722 0.531345575603725 0.80558845333468 CNTNAP2/BAX 2 GO:0140115 export across plasma membrane 2/436 76/18722 0.531345575603725 0.80558845333468 CALM2/ATP1B3 2 GO:0030218 erythrocyte differentiation 3/436 120/18722 0.532087321939838 0.805645013934502 HMGB2/PRKDC/SLC25A5 3 GO:0051897 positive regulation of protein kinase B signaling 3/436 120/18722 0.532087321939838 0.805645013934502 HSP90AA1/C1QBP/GPX1 3 GO:0071901 negative regulation of protein serine/threonine kinase activity 3/436 120/18722 0.532087321939838 0.805645013934502 NUP62/CDKN2A/GSTP1 3 GO:0050680 negative regulation of epithelial cell proliferation 4/436 164/18722 0.53313593122706 0.806876656391725 BRCA2/MARVELD3/SUZ12/PHB2 4 GO:0090257 regulation of muscle system process 6/436 252/18722 0.53562192702317 0.80919623412187 CALM2/PARP1/PARP2/ENO1/C12orf57/GSTO1 6 GO:0001838 embryonic epithelial tube formation 3/436 121/18722 0.537698117778868 0.80919623412187 KIF20B/RPS7/SPINT2 3 GO:0038127 ERBB signaling pathway 3/436 121/18722 0.537698117778868 0.80919623412187 NUP62/SNX5/EFEMP1 3 GO:0043244 regulation of protein-containing complex disassembly 3/436 121/18722 0.537698117778868 0.80919623412187 TPX2/CKAP2/RDX 3 GO:0043500 muscle adaptation 3/436 121/18722 0.537698117778868 0.80919623412187 EZH2/PARP1/PARP2 3 GO:0055117 regulation of cardiac muscle contraction 2/436 77/18722 0.538401295076691 0.80919623412187 CALM2/GSTO1 2 GO:0071222 cellular response to lipopolysaccharide 5/436 209/18722 0.53860967100064 0.80919623412187 HMGB2/HMGB1/CDK4/PRDX2/GSTP1 5 GO:0006505 GPI anchor metabolic process 1/436 33/18722 0.540800630965155 0.80919623412187 PGAP2 1 GO:0010737 protein kinase A signaling 1/436 33/18722 0.540800630965155 0.80919623412187 RDX 1 GO:0010984 regulation of lipoprotein particle clearance 1/436 33/18722 0.540800630965155 0.80919623412187 LRPAP1 1 GO:0018345 protein palmitoylation 1/436 33/18722 0.540800630965155 0.80919623412187 ZDHHC12 1 GO:0019362 pyridine nucleotide metabolic process 1/436 33/18722 0.540800630965155 0.80919623412187 IDH2 1 GO:0031116 positive regulation of microtubule polymerization 1/436 33/18722 0.540800630965155 0.80919623412187 RPS3 1 GO:0032228 regulation of synaptic transmission, GABAergic 1/436 33/18722 0.540800630965155 0.80919623412187 ZDHHC12 1 GO:0033198 response to ATP 1/436 33/18722 0.540800630965155 0.80919623412187 HSPD1 1 GO:0034110 regulation of homotypic cell-cell adhesion 1/436 33/18722 0.540800630965155 0.80919623412187 RDX 1 GO:0046496 nicotinamide nucleotide metabolic process 1/436 33/18722 0.540800630965155 0.80919623412187 IDH2 1 GO:0048048 embryonic eye morphogenesis 1/436 33/18722 0.540800630965155 0.80919623412187 EFEMP1 1 GO:0071539 protein localization to centrosome 1/436 33/18722 0.540800630965155 0.80919623412187 NUP62 1 GO:0071763 nuclear membrane organization 1/436 33/18722 0.540800630965155 0.80919623412187 VRK1 1 GO:0099084 postsynaptic specialization organization 1/436 33/18722 0.540800630965155 0.80919623412187 ZDHHC12 1 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 1/436 33/18722 0.540800630965155 0.80919623412187 TACSTD2 1 GO:1901099 negative regulation of signal transduction in absence of ligand 1/436 33/18722 0.540800630965155 0.80919623412187 PRDX2 1 GO:1902692 regulation of neuroblast proliferation 1/436 33/18722 0.540800630965155 0.80919623412187 ASPM 1 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 1/436 33/18722 0.540800630965155 0.80919623412187 CDKN2A 1 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/436 33/18722 0.540800630965155 0.80919623412187 PRDX2 1 GO:0043112 receptor metabolic process 4/436 166/18722 0.542712757798782 0.810770234358284 NSG1/CD81/PLEKHJ1/LRPAP1 4 GO:0045637 regulation of myeloid cell differentiation 5/436 210/18722 0.542857143856487 0.810770234358284 HMGB2/HMGB1/PRKDC/JUN/NME1 5 GO:0002688 regulation of leukocyte chemotaxis 3/436 122/18722 0.543270407691546 0.810770234358284 HMGB1/DDT/C1QBP 3 GO:0051208 sequestering of calcium ion 3/436 122/18722 0.543270407691546 0.810770234358284 CALM2/BAX/GSTO1 3 GO:0051928 positive regulation of calcium ion transport 3/436 122/18722 0.543270407691546 0.810770234358284 CALM2/BAX/GSTO1 3 GO:1990266 neutrophil migration 3/436 122/18722 0.543270407691546 0.810770234358284 CKLF/PPIA/C1QBP 3 GO:0043297 apical junction assembly 2/436 78/18722 0.545383455853397 0.812918341190079 MARVELD3/CLDN7 2 GO:1901616 organic hydroxy compound catabolic process 2/436 78/18722 0.545383455853397 0.812918341190079 IMPA2/TPI1 2 GO:0042180 cellular ketone metabolic process 5/436 211/18722 0.547086281216976 0.812918341190079 BRCA1/AKR7A2/VKORC1/PNKD/TPI1 5 GO:0031667 response to nutrient levels 11/436 474/18722 0.547734769096989 0.812918341190079 TYMS/HAT1/SRSF2/JUN/EIF4EBP1/GSTP1/MGMT/CTSV/HSPA8/CCND1/LDHA 11 GO:0006690 icosanoid metabolic process 3/436 123/18722 0.548803686581745 0.812918341190079 GSTP1/PTGES3/GPX1 3 GO:0010811 positive regulation of cell-substrate adhesion 3/436 123/18722 0.548803686581745 0.812918341190079 EMP2/C1QBP/CCDC80 3 GO:0009749 response to glucose 5/436 212/18722 0.551296769336139 0.812918341190079 SLC29A1/CTSV/NME1/MPC2/LDHA 5 GO:0000096 sulfur amino acid metabolic process 1/436 34/18722 0.551513399165657 0.812918341190079 MTAP 1 GO:0001662 behavioral fear response 1/436 34/18722 0.551513399165657 0.812918341190079 VDAC1 1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 1/436 34/18722 0.551513399165657 0.812918341190079 CTSV 1 GO:0006356 regulation of transcription by RNA polymerase I 1/436 34/18722 0.551513399165657 0.812918341190079 POLR2L 1 GO:0009303 rRNA transcription 1/436 34/18722 0.551513399165657 0.812918341190079 TCOF1 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/436 34/18722 0.551513399165657 0.812918341190079 CDKN2A 1 GO:0019076 viral release from host cell 1/436 34/18722 0.551513399165657 0.812918341190079 PPIA 1 GO:0019320 hexose catabolic process 1/436 34/18722 0.551513399165657 0.812918341190079 ENO1 1 GO:0032743 positive regulation of interleukin-2 production 1/436 34/18722 0.551513399165657 0.812918341190079 RPS3 1 GO:0032770 positive regulation of monooxygenase activity 1/436 34/18722 0.551513399165657 0.812918341190079 DHFR 1 GO:0035308 negative regulation of protein dephosphorylation 1/436 34/18722 0.551513399165657 0.812918341190079 MASTL 1 GO:0035890 exit from host 1/436 34/18722 0.551513399165657 0.812918341190079 PPIA 1 GO:0035891 exit from host cell 1/436 34/18722 0.551513399165657 0.812918341190079 PPIA 1 GO:0043276 anoikis 1/436 34/18722 0.551513399165657 0.812918341190079 TFDP1 1 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 1/436 34/18722 0.551513399165657 0.812918341190079 EEF1E1 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/436 34/18722 0.551513399165657 0.812918341190079 LRPAP1 1 GO:0048536 spleen development 1/436 34/18722 0.551513399165657 0.812918341190079 PRKDC 1 GO:0048741 skeletal muscle fiber development 1/436 34/18722 0.551513399165657 0.812918341190079 GPX1 1 GO:0055094 response to lipoprotein particle 1/436 34/18722 0.551513399165657 0.812918341190079 CD81 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/436 34/18722 0.551513399165657 0.812918341190079 SUZ12 1 GO:0006446 regulation of translational initiation 2/436 79/18722 0.552291650630741 0.812918341190079 EIF4EBP1/KHDRBS1 2 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 2/436 79/18722 0.552291650630741 0.812918341190079 PRKDC/C1QBP 2 GO:0032272 negative regulation of protein polymerization 2/436 79/18722 0.552291650630741 0.812918341190079 STMN1/RDX 2 GO:0060420 regulation of heart growth 2/436 79/18722 0.552291650630741 0.812918341190079 CDK1/PARP2 2 GO:1901184 regulation of ERBB signaling pathway 2/436 79/18722 0.552291650630741 0.812918341190079 NUP62/SNX5 2 GO:0005996 monosaccharide metabolic process 6/436 257/18722 0.554870179933867 0.816363459413849 HMGB1/PGP/SLC25A1/ENO1/TPI1/GSTO1 6 GO:0051651 maintenance of location in cell 5/436 213/18722 0.555488302997192 0.816922575046448 BARD1/ASPM/CALM2/BAX/GSTO1 5 GO:0006937 regulation of muscle contraction 4/436 169/18722 0.556887048488914 0.818396614352093 CALM2/ENO1/C12orf57/GSTO1 4 GO:0021766 hippocampus development 2/436 80/18722 0.55912553079567 0.818396614352093 EZH2/NME1 2 GO:0120193 tight junction organization 2/436 80/18722 0.55912553079567 0.818396614352093 MARVELD3/CLDN7 2 GO:0072330 monocarboxylic acid biosynthetic process 5/436 214/18722 0.559660585457663 0.818396614352093 BRCA1/HACD3/SLC27A2/GSTP1/PTGES3 5 GO:0055007 cardiac muscle cell differentiation 3/436 125/18722 0.559751324106939 0.818396614352093 CDK1/CACYBP/PARP2 3 GO:0071621 granulocyte chemotaxis 3/436 125/18722 0.559751324106939 0.818396614352093 CKLF/PPIA/C1QBP 3 GO:0001893 maternal placenta development 1/436 35/18722 0.561976806590945 0.818396614352093 CTSV 1 GO:0002209 behavioral defense response 1/436 35/18722 0.561976806590945 0.818396614352093 VDAC1 1 GO:0003298 physiological muscle hypertrophy 1/436 35/18722 0.561976806590945 0.818396614352093 PARP2 1 GO:0003301 physiological cardiac muscle hypertrophy 1/436 35/18722 0.561976806590945 0.818396614352093 PARP2 1 GO:0009119 ribonucleoside metabolic process 1/436 35/18722 0.561976806590945 0.818396614352093 MTAP 1 GO:0010765 positive regulation of sodium ion transport 1/436 35/18722 0.561976806590945 0.818396614352093 ATP1B3 1 GO:0015695 organic cation transport 1/436 35/18722 0.561976806590945 0.818396614352093 SLC29A1 1 GO:0032205 negative regulation of telomere maintenance 1/436 35/18722 0.561976806590945 0.818396614352093 PARP1 1 GO:0039694 viral RNA genome replication 1/436 35/18722 0.561976806590945 0.818396614352093 TOP2A 1 GO:0044273 sulfur compound catabolic process 1/436 35/18722 0.561976806590945 0.818396614352093 NUDT8 1 GO:0045922 negative regulation of fatty acid metabolic process 1/436 35/18722 0.561976806590945 0.818396614352093 BRCA1 1 GO:0046471 phosphatidylglycerol metabolic process 1/436 35/18722 0.561976806590945 0.818396614352093 PHB2 1 GO:0046640 regulation of alpha-beta T cell proliferation 1/436 35/18722 0.561976806590945 0.818396614352093 CD81 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/436 35/18722 0.561976806590945 0.818396614352093 PARP2 1 GO:0098810 neurotransmitter reuptake 1/436 35/18722 0.561976806590945 0.818396614352093 SLC29A1 1 GO:1905508 protein localization to microtubule organizing center 1/436 35/18722 0.561976806590945 0.818396614352093 NUP62 1 GO:1905898 positive regulation of response to endoplasmic reticulum stress 1/436 35/18722 0.561976806590945 0.818396614352093 BAX 1 GO:0021954 central nervous system neuron development 2/436 81/18722 0.565884803924295 0.822459304788055 HSP90AA1/C12orf57 2 GO:0046209 nitric oxide metabolic process 2/436 81/18722 0.565884803924295 0.822459304788055 GCHFR/HSP90AA1 2 GO:0071260 cellular response to mechanical stimulus 2/436 81/18722 0.565884803924295 0.822459304788055 CHEK1/CASP8AP2 2 GO:2000243 positive regulation of reproductive process 2/436 81/18722 0.565884803924295 0.822459304788055 RAD51AP1/C1QBP 2 GO:0048469 cell maturation 4/436 171/18722 0.566204860947067 0.822459304788055 TYMS/FBXO5/BRCA2/CNTNAP2 4 GO:0051048 negative regulation of secretion 4/436 171/18722 0.566204860947067 0.822459304788055 HADH/PNKD/IDH2/ERP29 4 GO:0001678 cellular glucose homeostasis 4/436 172/18722 0.570823200418113 0.824374751495604 SLC29A1/NUCKS1/NME1/MPC2 4 GO:0002221 pattern recognition receptor signaling pathway 4/436 172/18722 0.570823200418113 0.824374751495604 HMGB1/C1QBP/HSPD1/PHB2 4 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1/436 36/18722 0.572196644570629 0.824374751495604 CTSV 1 GO:0006699 bile acid biosynthetic process 1/436 36/18722 0.572196644570629 0.824374751495604 SLC27A2 1 GO:0010923 negative regulation of phosphatase activity 1/436 36/18722 0.572196644570629 0.824374751495604 MASTL 1 GO:0030224 monocyte differentiation 1/436 36/18722 0.572196644570629 0.824374751495604 JUN 1 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 1/436 36/18722 0.572196644570629 0.824374751495604 MPC2 1 GO:0042092 type 2 immune response 1/436 36/18722 0.572196644570629 0.824374751495604 CD81 1 GO:0045652 regulation of megakaryocyte differentiation 1/436 36/18722 0.572196644570629 0.824374751495604 HMGB2 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/436 36/18722 0.572196644570629 0.824374751495604 NUP62 1 GO:0060251 regulation of glial cell proliferation 1/436 36/18722 0.572196644570629 0.824374751495604 IDH2 1 GO:0070873 regulation of glycogen metabolic process 1/436 36/18722 0.572196644570629 0.824374751495604 HMGB1 1 GO:0070897 transcription preinitiation complex assembly 1/436 36/18722 0.572196644570629 0.824374751495604 HMGB1 1 GO:0071402 cellular response to lipoprotein particle stimulus 1/436 36/18722 0.572196644570629 0.824374751495604 CD81 1 GO:0086010 membrane depolarization during action potential 1/436 36/18722 0.572196644570629 0.824374751495604 YWHAH 1 GO:0090313 regulation of protein targeting to membrane 1/436 36/18722 0.572196644570629 0.824374751495604 HRAS 1 GO:1901658 glycosyl compound catabolic process 1/436 36/18722 0.572196644570629 0.824374751495604 NUDT1 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/436 36/18722 0.572196644570629 0.824374751495604 RPS3 1 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 1/436 36/18722 0.572196644570629 0.824374751495604 SAE1 1 GO:0060395 SMAD protein signal transduction 2/436 82/18722 0.572569231365207 0.824374751495604 PARP1/JUN 2 GO:2001057 reactive nitrogen species metabolic process 2/436 82/18722 0.572569231365207 0.824374751495604 GCHFR/HSP90AA1 2 GO:0031330 negative regulation of cellular catabolic process 6/436 262/18722 0.573745415115981 0.825721694321699 PBK/FUS/SVIP/HNRNPD/YBX1/RPS7 6 GO:0033865 nucleoside bisphosphate metabolic process 3/436 128/18722 0.575869078672745 0.827736409269455 NUDT8/SLC25A1/MPC2 3 GO:0033875 ribonucleoside bisphosphate metabolic process 3/436 128/18722 0.575869078672745 0.827736409269455 NUDT8/SLC25A1/MPC2 3 GO:0034032 purine nucleoside bisphosphate metabolic process 3/436 128/18722 0.575869078672745 0.827736409269455 NUDT8/SLC25A1/MPC2 3 GO:0001659 temperature homeostasis 4/436 174/18722 0.579977126809111 0.830887967752409 ID1/HADH/FH/GPX1 4 GO:0045619 regulation of lymphocyte differentiation 4/436 174/18722 0.579977126809111 0.830887967752409 HMGB1/PRKDC/PRDX2/XRCC6 4 GO:0009746 response to hexose 5/436 219/18722 0.580223429539739 0.830887967752409 SLC29A1/CTSV/NME1/MPC2/LDHA 5 GO:0034764 positive regulation of transmembrane transport 5/436 219/18722 0.580223429539739 0.830887967752409 CALM2/ATP1B3/BAX/GSTO1/NDUFA4 5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1/436 37/18722 0.582178570235148 0.830887967752409 MAGOHB 1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/436 37/18722 0.582178570235148 0.830887967752409 RPS21 1 GO:0002369 T cell cytokine production 1/436 37/18722 0.582178570235148 0.830887967752409 CD81 1 GO:0002724 regulation of T cell cytokine production 1/436 37/18722 0.582178570235148 0.830887967752409 CD81 1 GO:0006623 protein targeting to vacuole 1/436 37/18722 0.582178570235148 0.830887967752409 HSPA8 1 GO:0014904 myotube cell development 1/436 37/18722 0.582178570235148 0.830887967752409 GPX1 1 GO:0016202 regulation of striated muscle tissue development 1/436 37/18722 0.582178570235148 0.830887967752409 CENPF 1 GO:0021532 neural tube patterning 1/436 37/18722 0.582178570235148 0.830887967752409 TMEM107 1 GO:0031112 positive regulation of microtubule polymerization or depolymerization 1/436 37/18722 0.582178570235148 0.830887967752409 RPS3 1 GO:0032570 response to progesterone 1/436 37/18722 0.582178570235148 0.830887967752409 TYMS 1 GO:0060416 response to growth hormone 1/436 37/18722 0.582178570235148 0.830887967752409 CACYBP 1 GO:0090218 positive regulation of lipid kinase activity 1/436 37/18722 0.582178570235148 0.830887967752409 CD81 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/436 37/18722 0.582178570235148 0.830887967752409 EZH2 1 GO:0002064 epithelial cell development 5/436 220/18722 0.584274440243245 0.833508037093253 TYMS/FAT1/SPINT2/RDX/GPX1 5 GO:0051607 defense response to virus 6/436 265/18722 0.584879560705965 0.833508037093253 HERC5/POLR3K/HSP90AA1/ILF3/C1QBP/PHB2 6 GO:0140546 defense response to symbiont 6/436 265/18722 0.584879560705965 0.833508037093253 HERC5/POLR3K/HSP90AA1/ILF3/C1QBP/PHB2 6 GO:0002088 lens development in camera-type eye 2/436 84/18722 0.585712849509615 0.833508037093253 CDK4/FAT1 2 GO:0006112 energy reserve metabolic process 2/436 84/18722 0.585712849509615 0.833508037093253 HMGB1/PTGES3 2 GO:0045445 myoblast differentiation 2/436 84/18722 0.585712849509615 0.833508037093253 DTYMK/ID3 2 GO:0032409 regulation of transporter activity 7/436 310/18722 0.585957850617583 0.833508037093253 YWHAH/CALM2/PPIF/ATP1B3/GSTO1/NDUFA4/PHB2 7 GO:0060326 cell chemotaxis 7/436 310/18722 0.585957850617583 0.833508037093253 HMGB2/HMGB1/CKLF/PPIA/DDT/GSTP1/C1QBP 7 GO:0042476 odontogenesis 3/436 130/18722 0.586407379480367 0.83380178988692 ID3/BAX/PERP 3 GO:0010810 regulation of cell-substrate adhesion 5/436 221/18722 0.588304354720227 0.835420018116156 EMP2/CDKN2A/TACSTD2/C1QBP/CCDC80 5 GO:0071219 cellular response to molecule of bacterial origin 5/436 221/18722 0.588304354720227 0.835420018116156 HMGB2/HMGB1/CDK4/PRDX2/GSTP1 5 GO:0043534 blood vessel endothelial cell migration 4/436 176/18722 0.589018711027984 0.835420018116156 HMGB1/ID1/EMP2/GPX1 4 GO:0050853 B cell receptor signaling pathway 3/436 131/18722 0.591613480092327 0.835420018116156 CD81/BAX/SLC39A10 3 GO:0002478 antigen processing and presentation of exogenous peptide antigen 1/436 38/18722 0.591928109618476 0.835420018116156 CTSV 1 GO:0042596 fear response 1/436 38/18722 0.591928109618476 0.835420018116156 VDAC1 1 GO:0046633 alpha-beta T cell proliferation 1/436 38/18722 0.591928109618476 0.835420018116156 CD81 1 GO:0046676 negative regulation of insulin secretion 1/436 38/18722 0.591928109618476 0.835420018116156 HADH 1 GO:0072524 pyridine-containing compound metabolic process 1/436 38/18722 0.591928109618476 0.835420018116156 IDH2 1 GO:0097242 amyloid-beta clearance 1/436 38/18722 0.591928109618476 0.835420018116156 LRPAP1 1 GO:0098926 postsynaptic signal transduction 1/436 38/18722 0.591928109618476 0.835420018116156 LY6E 1 GO:1901031 regulation of response to reactive oxygen species 1/436 38/18722 0.591928109618476 0.835420018116156 DHFR 1 GO:1901186 positive regulation of ERBB signaling pathway 1/436 38/18722 0.591928109618476 0.835420018116156 NUP62 1 GO:1903580 positive regulation of ATP metabolic process 1/436 38/18722 0.591928109618476 0.835420018116156 ENO1 1 GO:1903725 regulation of phospholipid metabolic process 1/436 38/18722 0.591928109618476 0.835420018116156 PHB2 1 GO:0001656 metanephros development 2/436 85/18722 0.592171811150829 0.835420018116156 ID3/CTSH 2 GO:0055013 cardiac muscle cell development 2/436 85/18722 0.592171811150829 0.835420018116156 CDK1/PARP2 2 GO:0060021 roof of mouth development 2/436 85/18722 0.592171811150829 0.835420018116156 ANP32B/TMEM107 2 GO:0097194 execution phase of apoptosis 2/436 85/18722 0.592171811150829 0.835420018116156 TOP2A/BAX 2 GO:0010631 epithelial cell migration 8/436 357/18722 0.593676656379688 0.837198770258409 HMGB1/ANLN/ID1/EMP2/MARVELD3/TACSTD2/GPX1/CTSH 8 GO:0072175 epithelial tube formation 3/436 132/18722 0.59677716107386 0.84122532442252 KIF20B/RPS7/SPINT2 3 GO:0009798 axis specification 2/436 86/18722 0.598555464695988 0.843039326507363 HSPB11/WLS 2 GO:0032413 negative regulation of ion transmembrane transporter activity 2/436 86/18722 0.598555464695988 0.843039326507363 CALM2/GSTO1 2 GO:0046394 carboxylic acid biosynthetic process 7/436 314/18722 0.599494158518823 0.844014960146936 DHFR/BRCA1/HACD3/SLC27A2/MTAP/GSTP1/PTGES3 7 GO:0002701 negative regulation of production of molecular mediator of immune response 1/436 39/18722 0.60145066068925 0.844344196736831 PRKDC 1 GO:0034314 Arp2/3 complex-mediated actin nucleation 1/436 39/18722 0.60145066068925 0.844344196736831 ARPC5L 1 GO:0042417 dopamine metabolic process 1/436 39/18722 0.60145066068925 0.844344196736831 PNKD 1 GO:0071548 response to dexamethasone 1/436 39/18722 0.60145066068925 0.844344196736831 PCNA 1 GO:1901861 regulation of muscle tissue development 1/436 39/18722 0.60145066068925 0.844344196736831 CENPF 1 GO:2000249 regulation of actin cytoskeleton reorganization 1/436 39/18722 0.60145066068925 0.844344196736831 HRAS 1 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 1/436 39/18722 0.60145066068925 0.844344196736831 CD81 1 GO:0090132 epithelium migration 8/436 360/18722 0.603123746768422 0.846346656508162 HMGB1/ANLN/ID1/EMP2/MARVELD3/TACSTD2/GPX1/CTSH 8 GO:0019915 lipid storage 2/436 87/18722 0.604863806878288 0.84844142330311 SQLE/HILPDA 2 GO:0016053 organic acid biosynthetic process 7/436 316/18722 0.606176607106693 0.849935406204766 DHFR/BRCA1/HACD3/SLC27A2/MTAP/GSTP1/PTGES3 7 GO:0061041 regulation of wound healing 3/436 134/18722 0.606976235796724 0.850708931788628 HMGB1/PRDX2/HRAS 3 GO:0007339 binding of sperm to zona pellucida 1/436 40/18722 0.610751496311981 0.853027907142588 CCT5 1 GO:0014037 Schwann cell differentiation 1/436 40/18722 0.610751496311981 0.853027907142588 CDK1 1 GO:0030866 cortical actin cytoskeleton organization 1/436 40/18722 0.610751496311981 0.853027907142588 ANLN 1 GO:0042073 intraciliary transport 1/436 40/18722 0.610751496311981 0.853027907142588 HSPB11 1 GO:0045429 positive regulation of nitric oxide biosynthetic process 1/436 40/18722 0.610751496311981 0.853027907142588 HSP90AA1 1 GO:0046365 monosaccharide catabolic process 1/436 40/18722 0.610751496311981 0.853027907142588 ENO1 1 GO:0070266 necroptotic process 1/436 40/18722 0.610751496311981 0.853027907142588 PPIF 1 GO:1901998 toxin transport 1/436 40/18722 0.610751496311981 0.853027907142588 CCT5 1 GO:0032640 tumor necrosis factor production 4/436 181/18722 0.611117049185801 0.853027907142588 HMGB1/DDT/GSTP1/HSPD1 4 GO:0032680 regulation of tumor necrosis factor production 4/436 181/18722 0.611117049185801 0.853027907142588 HMGB1/DDT/GSTP1/HSPD1 4 GO:0001101 response to acid chemical 3/436 135/18722 0.612011168085969 0.853605492548285 PCNA/HNRNPD/GSTP1 3 GO:0046777 protein autophosphorylation 5/436 227/18722 0.612028420772014 0.853605492548285 VRK1/MELK/AURKB/TTK/CALM2 5 GO:0051260 protein homooligomerization 4/436 182/18722 0.615448132237979 0.857051039448183 BLM/TK1/FUS/RBMX 4 GO:0060401 cytosolic calcium ion transport 4/436 182/18722 0.615448132237979 0.857051039448183 CALM2/BAX/VDAC1/GSTO1 4 GO:0061138 morphogenesis of a branching epithelium 4/436 182/18722 0.615448132237979 0.857051039448183 TACSTD2/SPINT2/PHB2/CTSH 4 GO:0002696 positive regulation of leukocyte activation 9/436 409/18722 0.615498035907993 0.857051039448183 HMGB1/MSH2/PRKDC/CD81/RPS3/RIF1/SLC39A10/XRCC6/HSPD1 9 GO:0003158 endothelium development 3/436 136/18722 0.617002756800515 0.857868703935919 ID1/RDX/GPX1 3 GO:0046330 positive regulation of JNK cascade 2/436 89/18722 0.617254746705878 0.857868703935919 HMGB1/HRAS 2 GO:0090130 tissue migration 8/436 365/18722 0.618620022398162 0.857868703935919 HMGB1/ANLN/ID1/EMP2/MARVELD3/TACSTD2/GPX1/CTSH 8 GO:0009895 negative regulation of catabolic process 7/436 320/18722 0.619364210865055 0.857868703935919 MAD2L1/PBK/FUS/SVIP/HNRNPD/YBX1/RPS7 7 GO:0001953 negative regulation of cell-matrix adhesion 1/436 41/18722 0.619835767139942 0.857868703935919 CDKN2A 1 GO:0010907 positive regulation of glucose metabolic process 1/436 41/18722 0.619835767139942 0.857868703935919 HMGB1 1 GO:0048286 lung alveolus development 1/436 41/18722 0.619835767139942 0.857868703935919 PTGES3 1 GO:0048634 regulation of muscle organ development 1/436 41/18722 0.619835767139942 0.857868703935919 CENPF 1 GO:0050691 regulation of defense response to virus by host 1/436 41/18722 0.619835767139942 0.857868703935919 HSP90AA1 1 GO:0051693 actin filament capping 1/436 41/18722 0.619835767139942 0.857868703935919 RDX 1 GO:0060612 adipose tissue development 1/436 41/18722 0.619835767139942 0.857868703935919 CDK4 1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 1/436 41/18722 0.619835767139942 0.857868703935919 C1QBP 1 GO:1902116 negative regulation of organelle assembly 1/436 41/18722 0.619835767139942 0.857868703935919 BRCA1 1 GO:1902622 regulation of neutrophil migration 1/436 41/18722 0.619835767139942 0.857868703935919 C1QBP 1 GO:1904407 positive regulation of nitric oxide metabolic process 1/436 41/18722 0.619835767139942 0.857868703935919 HSP90AA1 1 GO:0007266 Rho protein signal transduction 3/436 137/18722 0.621950821605825 0.860102083405718 STMN1/HACD3/CTNNAL1 3 GO:0008203 cholesterol metabolic process 3/436 137/18722 0.621950821605825 0.860102083405718 FDPS/DHCR24/SQLE 3 GO:0002028 regulation of sodium ion transport 2/436 90/18722 0.623337534817761 0.86063222614074 YWHAH/ATP1B3 2 GO:0034109 homotypic cell-cell adhesion 2/436 90/18722 0.623337534817761 0.86063222614074 PPIA/RDX 2 GO:0042475 odontogenesis of dentin-containing tooth 2/436 90/18722 0.623337534817761 0.86063222614074 BAX/PERP 2 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 2/436 90/18722 0.623337534817761 0.86063222614074 JUN/GSTP1 2 GO:0030595 leukocyte chemotaxis 5/436 230/18722 0.623588671045772 0.86063263489865 HMGB1/CKLF/PPIA/DDT/C1QBP 5 GO:0055001 muscle cell development 4/436 184/18722 0.624020044329893 0.860881693645301 CDK1/PARP2/CSRP2/GPX1 4 GO:0043010 camera-type eye development 7/436 322/18722 0.625867193511585 0.861301966228568 RRM1/CDK4/FAT1/HMGN1/BAX/C12orf57/EFEMP1 7 GO:0032273 positive regulation of protein polymerization 3/436 138/18722 0.6268552014069 0.861301966228568 HSP90AA1/ARPC5L/RPS3 3 GO:0007212 dopamine receptor signaling pathway 1/436 42/18722 0.628708504441317 0.861301966228568 NSG1 1 GO:0007520 myoblast fusion 1/436 42/18722 0.628708504441317 0.861301966228568 CD81 1 GO:0010677 negative regulation of cellular carbohydrate metabolic process 1/436 42/18722 0.628708504441317 0.861301966228568 PGP 1 GO:0010939 regulation of necrotic cell death 1/436 42/18722 0.628708504441317 0.861301966228568 PPIF 1 GO:0014003 oligodendrocyte development 1/436 42/18722 0.628708504441317 0.861301966228568 GSTP1 1 GO:0014912 negative regulation of smooth muscle cell migration 1/436 42/18722 0.628708504441317 0.861301966228568 GSTP1 1 GO:0032691 negative regulation of interleukin-1 beta production 1/436 42/18722 0.628708504441317 0.861301966228568 GSTP1 1 GO:0043507 positive regulation of JUN kinase activity 1/436 42/18722 0.628708504441317 0.861301966228568 RPS3 1 GO:0045214 sarcomere organization 1/436 42/18722 0.628708504441317 0.861301966228568 CSRP2 1 GO:0046596 regulation of viral entry into host cell 1/436 42/18722 0.628708504441317 0.861301966228568 LY6E 1 GO:0051602 response to electrical stimulus 1/436 42/18722 0.628708504441317 0.861301966228568 HNRNPD 1 GO:0072595 maintenance of protein localization in organelle 1/436 42/18722 0.628708504441317 0.861301966228568 BARD1 1 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 1/436 42/18722 0.628708504441317 0.861301966228568 JUN 1 GO:2001222 regulation of neuron migration 1/436 42/18722 0.628708504441317 0.861301966228568 KIF20B 1 GO:0051492 regulation of stress fiber assembly 2/436 91/18722 0.629345388905572 0.861301966228568 STMN1/TACSTD2 2 GO:0055006 cardiac cell development 2/436 91/18722 0.629345388905572 0.861301966228568 CDK1/PARP2 2 GO:0060191 regulation of lipase activity 2/436 91/18722 0.629345388905572 0.861301966228568 HRAS/PHB2 2 GO:1990874 vascular associated smooth muscle cell proliferation 2/436 91/18722 0.629345388905572 0.861301966228568 JUN/GSTP1 2 GO:0032271 regulation of protein polymerization 5/436 232/18722 0.631180473188828 0.863468980666215 STMN1/HSP90AA1/ARPC5L/RPS3/RDX 5 GO:0016579 protein deubiquitination 3/436 139/18722 0.631715753847711 0.863855891346302 CDK1/USP1/USP48 3 GO:0031345 negative regulation of cell projection organization 4/436 186/18722 0.632470416514693 0.863855891346302 YWHAH/ID1/TACSTD2/ITM2C 4 GO:0071706 tumor necrosis factor superfamily cytokine production 4/436 186/18722 0.632470416514693 0.863855891346302 HMGB1/DDT/GSTP1/HSPD1 4 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 4/436 186/18722 0.632470416514693 0.863855891346302 HMGB1/DDT/GSTP1/HSPD1 4 GO:1902105 regulation of leukocyte differentiation 6/436 279/18722 0.634776440561216 0.864702384750153 HMGB1/PRKDC/JUN/PRDX2/NME1/XRCC6 6 GO:1903351 cellular response to dopamine 2/436 92/18722 0.63527849191553 0.864702384750153 ID1/NSG1 2 GO:0001654 eye development 8/436 371/18722 0.636786665490533 0.864702384750153 RRM1/HMGB1/CDK4/FAT1/HMGN1/BAX/C12orf57/EFEMP1 8 GO:0001504 neurotransmitter uptake 1/436 43/18722 0.637374622860139 0.864702384750153 SLC29A1 1 GO:0006509 membrane protein ectodomain proteolysis 1/436 43/18722 0.637374622860139 0.864702384750153 RBMX 1 GO:0014014 negative regulation of gliogenesis 1/436 43/18722 0.637374622860139 0.864702384750153 IDH2 1 GO:0031952 regulation of protein autophosphorylation 1/436 43/18722 0.637374622860139 0.864702384750153 CALM2 1 GO:0034142 toll-like receptor 4 signaling pathway 1/436 43/18722 0.637374622860139 0.864702384750153 HMGB1 1 GO:0042181 ketone biosynthetic process 1/436 43/18722 0.637374622860139 0.864702384750153 TPI1 1 GO:0045776 negative regulation of blood pressure 1/436 43/18722 0.637374622860139 0.864702384750153 SNX5 1 GO:0045981 positive regulation of nucleotide metabolic process 1/436 43/18722 0.637374622860139 0.864702384750153 ENO1 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/436 43/18722 0.637374622860139 0.864702384750153 HMGB1 1 GO:0090278 negative regulation of peptide hormone secretion 1/436 43/18722 0.637374622860139 0.864702384750153 HADH 1 GO:1900544 positive regulation of purine nucleotide metabolic process 1/436 43/18722 0.637374622860139 0.864702384750153 ENO1 1 GO:1901381 positive regulation of potassium ion transmembrane transport 1/436 43/18722 0.637374622860139 0.864702384750153 ATP1B3 1 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 1/436 43/18722 0.637374622860139 0.864702384750153 GSTP1 1 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/436 43/18722 0.637374622860139 0.864702384750153 PRDX2 1 GO:0051235 maintenance of location 7/436 326/18722 0.638686532343391 0.866139720343943 BARD1/ASPM/CALM2/SQLE/HILPDA/BAX/GSTO1 7 GO:0032088 negative regulation of NF-kappaB transcription factor activity 2/436 93/18722 0.641137058859998 0.867530423625916 CDKN2A/PRDX2 2 GO:0032755 positive regulation of interleukin-6 production 2/436 93/18722 0.641137058859998 0.867530423625916 HMGB1/HSPD1 2 GO:1901019 regulation of calcium ion transmembrane transporter activity 2/436 93/18722 0.641137058859998 0.867530423625916 CALM2/GSTO1 2 GO:1903350 response to dopamine 2/436 93/18722 0.641137058859998 0.867530423625916 ID1/NSG1 2 GO:0016241 regulation of macroautophagy 3/436 141/18722 0.641304897957881 0.867530423625916 SLC25A5/SNX5/VDAC1 3 GO:0007249 I-kappaB kinase/NF-kappaB signaling 6/436 281/18722 0.64161089688817 0.867530423625916 HACD3/NUP62/GSTP1/SLC20A1/WLS/PRDX4 6 GO:0030098 lymphocyte differentiation 8/436 374/18722 0.645687820508095 0.867530423625916 HMGB1/MSH2/EZH2/PRKDC/SLC25A5/PRDX2/BAX/XRCC6 8 GO:0002066 columnar/cuboidal epithelial cell development 1/436 44/18722 0.645838923113524 0.867530423625916 TYMS 1 GO:0002792 negative regulation of peptide secretion 1/436 44/18722 0.645838923113524 0.867530423625916 HADH 1 GO:0005978 glycogen biosynthetic process 1/436 44/18722 0.645838923113524 0.867530423625916 PTGES3 1 GO:0006775 fat-soluble vitamin metabolic process 1/436 44/18722 0.645838923113524 0.867530423625916 VKORC1 1 GO:0009250 glucan biosynthetic process 1/436 44/18722 0.645838923113524 0.867530423625916 PTGES3 1 GO:0031295 T cell costimulation 1/436 44/18722 0.645838923113524 0.867530423625916 CD81 1 GO:0032881 regulation of polysaccharide metabolic process 1/436 44/18722 0.645838923113524 0.867530423625916 HMGB1 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/436 44/18722 0.645838923113524 0.867530423625916 CADM1 1 GO:0042554 superoxide anion generation 1/436 44/18722 0.645838923113524 0.867530423625916 GSTP1 1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 1/436 44/18722 0.645838923113524 0.867530423625916 FAT1 1 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 1/436 44/18722 0.645838923113524 0.867530423625916 CENPJ 1 GO:0048066 developmental pigmentation 1/436 44/18722 0.645838923113524 0.867530423625916 BAX 1 GO:0050999 regulation of nitric-oxide synthase activity 1/436 44/18722 0.645838923113524 0.867530423625916 DHFR 1 GO:0060711 labyrinthine layer development 1/436 44/18722 0.645838923113524 0.867530423625916 SPINT2 1 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 1/436 44/18722 0.645838923113524 0.867530423625916 HMGB1 1 GO:1903573 negative regulation of response to endoplasmic reticulum stress 1/436 44/18722 0.645838923113524 0.867530423625916 SVIP 1 GO:0050729 positive regulation of inflammatory response 3/436 142/18722 0.646033294189512 0.867530423625916 DDT/CD81/HSPD1 3 GO:0097553 calcium ion transmembrane import into cytosol 3/436 142/18722 0.646033294189512 0.867530423625916 CALM2/BAX/GSTO1 3 GO:0050867 positive regulation of cell activation 9/436 420/18722 0.6468277482749 0.868043449816147 HMGB1/MSH2/PRKDC/CD81/RPS3/RIF1/SLC39A10/XRCC6/HSPD1 9 GO:0002690 positive regulation of leukocyte chemotaxis 2/436 94/18722 0.646921335231678 0.868043449816147 HMGB1/C1QBP 2 GO:0150063 visual system development 8/436 375/18722 0.648627243147229 0.869992209240869 RRM1/HMGB1/CDK4/FAT1/HMGN1/BAX/C12orf57/EFEMP1 8 GO:0019318 hexose metabolic process 5/436 237/18722 0.649748675935229 0.870815510599129 HMGB1/PGP/SLC25A1/ENO1/TPI1 5 GO:0031334 positive regulation of protein-containing complex assembly 5/436 237/18722 0.649748675935229 0.870815510599129 CDT1/HSP90AA1/ARPC5L/RPS3/BAX 5 GO:0038061 NIK/NF-kappaB signaling 3/436 143/18722 0.650717471227413 0.871773386872805 HMGB1/RPS3/PHB2 3 GO:0070371 ERK1 and ERK2 cascade 7/436 330/18722 0.651251060833006 0.872147693098378 CDK1/HMGB1/DDT/GSTP1/HRAS/PHB2/CTSH 7 GO:0002532 production of molecular mediator involved in inflammatory response 2/436 95/18722 0.652631595473975 0.872226199247609 EZH2/PRDX2 2 GO:0008585 female gonad development 2/436 95/18722 0.652631595473975 0.872226199247609 BRCA2/BAX 2 GO:0002920 regulation of humoral immune response 1/436 45/18722 0.654106094626668 0.872226199247609 C1QBP 1 GO:0003254 regulation of membrane depolarization 1/436 45/18722 0.654106094626668 0.872226199247609 PARP1 1 GO:0006110 regulation of glycolytic process 1/436 45/18722 0.654106094626668 0.872226199247609 PGAM1 1 GO:0030835 negative regulation of actin filament depolymerization 1/436 45/18722 0.654106094626668 0.872226199247609 RDX 1 GO:0035272 exocrine system development 1/436 45/18722 0.654106094626668 0.872226199247609 WLS 1 GO:0035305 negative regulation of dephosphorylation 1/436 45/18722 0.654106094626668 0.872226199247609 MASTL 1 GO:0042551 neuron maturation 1/436 45/18722 0.654106094626668 0.872226199247609 CNTNAP2 1 GO:0046189 phenol-containing compound biosynthetic process 1/436 45/18722 0.654106094626668 0.872226199247609 DDT 1 GO:1904646 cellular response to amyloid-beta 1/436 45/18722 0.654106094626668 0.872226199247609 PARP1 1 GO:0007612 learning 3/436 144/18722 0.655357373116091 0.872876998121626 CNTNAP2/JUN/VDAC1 3 GO:0106106 cold-induced thermogenesis 3/436 144/18722 0.655357373116091 0.872876998121626 ID1/HADH/FH 3 GO:0120161 regulation of cold-induced thermogenesis 3/436 144/18722 0.655357373116091 0.872876998121626 ID1/HADH/FH 3 GO:0044264 cellular polysaccharide metabolic process 2/436 96/18722 0.658268141505799 0.876073698024203 HMGB1/PTGES3 2 GO:0055017 cardiac muscle tissue growth 2/436 96/18722 0.658268141505799 0.876073698024203 CDK1/PARP2 2 GO:0001974 blood vessel remodeling 1/436 46/18722 0.662180718107033 0.87855454130906 BAX 1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1/436 46/18722 0.662180718107033 0.87855454130906 CADM1 1 GO:0031294 lymphocyte costimulation 1/436 46/18722 0.662180718107033 0.87855454130906 CD81 1 GO:0042398 cellular modified amino acid biosynthetic process 1/436 46/18722 0.662180718107033 0.87855454130906 DHFR 1 GO:0048701 embryonic cranial skeleton morphogenesis 1/436 46/18722 0.662180718107033 0.87855454130906 SLC39A1 1 GO:0055010 ventricular cardiac muscle tissue morphogenesis 1/436 46/18722 0.662180718107033 0.87855454130906 LY6E 1 GO:0061028 establishment of endothelial barrier 1/436 46/18722 0.662180718107033 0.87855454130906 RDX 1 GO:1900271 regulation of long-term synaptic potentiation 1/436 46/18722 0.662180718107033 0.87855454130906 NSG1 1 GO:1903131 mononuclear cell differentiation 9/436 426/18722 0.663303160405794 0.879703573000494 HMGB1/MSH2/EZH2/PRKDC/JUN/SLC25A5/PRDX2/BAX/XRCC6 9 GO:0120162 positive regulation of cold-induced thermogenesis 2/436 97/18722 0.663831301299099 0.880063831049926 HADH/FH 2 GO:0007043 cell-cell junction assembly 3/436 146/18722 0.66450420649722 0.880275649610796 CNTNAP2/MARVELD3/CLDN7 3 GO:0010675 regulation of cellular carbohydrate metabolic process 3/436 146/18722 0.66450420649722 0.880275649610796 HMGB1/PGP/PGAM1 3 GO:0030099 myeloid cell differentiation 8/436 381/18722 0.66596769329069 0.881180834308497 HMGB2/HMGB1/PRKDC/PARP1/JUN/SLC25A5/NME1/CD81 8 GO:0048880 sensory system development 8/436 381/18722 0.66596769329069 0.881180834308497 RRM1/HMGB1/CDK4/FAT1/HMGN1/BAX/C12orf57/EFEMP1 8 GO:1901605 alpha-amino acid metabolic process 4/436 195/18722 0.668962400612012 0.881180834308497 DHFR/GMPS/MTAP/GCSH 4 GO:0016331 morphogenesis of embryonic epithelium 3/436 147/18722 0.669011103590787 0.881180834308497 KIF20B/RPS7/SPINT2 3 GO:0043502 regulation of muscle adaptation 2/436 98/18722 0.669321427507484 0.881180834308497 PARP1/PARP2 2 GO:0006998 nuclear envelope organization 1/436 47/18722 0.670067268059128 0.881180834308497 VRK1 1 GO:0010761 fibroblast migration 1/436 47/18722 0.670067268059128 0.881180834308497 PDLIM1 1 GO:0010799 regulation of peptidyl-threonine phosphorylation 1/436 47/18722 0.670067268059128 0.881180834308497 CALM2 1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1/436 47/18722 0.670067268059128 0.881180834308497 GSTP1 1 GO:0019884 antigen processing and presentation of exogenous antigen 1/436 47/18722 0.670067268059128 0.881180834308497 CTSV 1 GO:0042311 vasodilation 1/436 47/18722 0.670067268059128 0.881180834308497 GPX1 1 GO:0045601 regulation of endothelial cell differentiation 1/436 47/18722 0.670067268059128 0.881180834308497 ID1 1 GO:0050885 neuromuscular process controlling balance 1/436 47/18722 0.670067268059128 0.881180834308497 IGDCC3 1 GO:0072583 clathrin-dependent endocytosis 1/436 47/18722 0.670067268059128 0.881180834308497 AP2S1 1 GO:0090279 regulation of calcium ion import 1/436 47/18722 0.670067268059128 0.881180834308497 VDAC1 1 GO:0097028 dendritic cell differentiation 1/436 47/18722 0.670067268059128 0.881180834308497 HMGB1 1 GO:0101023 vascular endothelial cell proliferation 1/436 47/18722 0.670067268059128 0.881180834308497 HMGB1 1 GO:0120163 negative regulation of cold-induced thermogenesis 1/436 47/18722 0.670067268059128 0.881180834308497 ID1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/436 47/18722 0.670067268059128 0.881180834308497 HMGB1 1 GO:0001667 ameboidal-type cell migration 10/436 475/18722 0.671617504366027 0.882881094819861 HMGB1/ANLN/ID1/EMP2/MARVELD3/TACSTD2/PDLIM1/C1QBP/GPX1/CTSH 10 GO:0001763 morphogenesis of a branching structure 4/436 196/18722 0.672859897309373 0.883837024375367 TACSTD2/SPINT2/PHB2/CTSH 4 GO:0022408 negative regulation of cell-cell adhesion 4/436 196/18722 0.672859897309373 0.883837024375367 HMGB1/PRDX2/SPINT2/RDX 4 GO:0035148 tube formation 3/436 148/18722 0.673473655845676 0.883966378426364 KIF20B/RPS7/SPINT2 3 GO:0097530 granulocyte migration 3/436 148/18722 0.673473655845676 0.883966378426364 CKLF/PPIA/C1QBP 3 GO:0042692 muscle cell differentiation 8/436 384/18722 0.674444116979638 0.884008080132203 CDK1/EZH2/CACYBP/PARP2/CSRP2/CD81/YBX1/GPX1 8 GO:0002429 immune response-activating cell surface receptor signaling pathway 6/436 291/18722 0.674616732833202 0.884008080132203 CD81/HRAS/RPS3/BAX/SLC39A10/KHDRBS1 6 GO:0002757 immune response-activating signal transduction 6/436 291/18722 0.674616732833202 0.884008080132203 CD81/HRAS/RPS3/BAX/SLC39A10/KHDRBS1 6 GO:0021549 cerebellum development 2/436 99/18722 0.674738896144334 0.884008080132203 EZH2/HNRNPD 2 GO:0001655 urogenital system development 7/436 338/18722 0.675591044201463 0.884008080132203 HELLS/CENPF/ID3/HSPB11/TACSTD2/BAX/CTSH 7 GO:0042594 response to starvation 4/436 197/18722 0.67672568006517 0.884008080132203 JUN/EIF4EBP1/CTSV/HSPA8 4 GO:0002673 regulation of acute inflammatory response 1/436 48/18722 0.677770115241255 0.884008080132203 GSTP1 1 GO:0002686 negative regulation of leukocyte migration 1/436 48/18722 0.677770115241255 0.884008080132203 DDT 1 GO:0002715 regulation of natural killer cell mediated immunity 1/436 48/18722 0.677770115241255 0.884008080132203 CADM1 1 GO:0006111 regulation of gluconeogenesis 1/436 48/18722 0.677770115241255 0.884008080132203 PGP 1 GO:0035036 sperm-egg recognition 1/436 48/18722 0.677770115241255 0.884008080132203 CCT5 1 GO:0045912 negative regulation of carbohydrate metabolic process 1/436 48/18722 0.677770115241255 0.884008080132203 PGP 1 GO:0070663 regulation of leukocyte proliferation 5/436 245/18722 0.678204828944597 0.884008080132203 HMGB1/GSTP1/CD81/RPS3/SLC39A10 5 GO:0006790 sulfur compound metabolic process 7/436 339/18722 0.678557971012894 0.884008080132203 NUDT8/MTAP/SLC25A1/GSTP1/MPC2/GSTO1/GPX1 7 GO:0006664 glycolipid metabolic process 2/436 100/18722 0.680084105308847 0.884008080132203 PGAP2/BAX 2 GO:0046545 development of primary female sexual characteristics 2/436 100/18722 0.680084105308847 0.884008080132203 BRCA2/BAX 2 GO:0110020 regulation of actomyosin structure organization 2/436 100/18722 0.680084105308847 0.884008080132203 STMN1/TACSTD2 2 GO:0007179 transforming growth factor beta receptor signaling pathway 4/436 198/18722 0.680559699475531 0.884008080132203 ID1/PARP1/JUN/NREP 4 GO:0050864 regulation of B cell activation 4/436 198/18722 0.680559699475531 0.884008080132203 MSH2/CD81/RIF1/SLC39A10 4 GO:0001822 kidney development 6/436 293/18722 0.680979433553605 0.884008080132203 CENPF/ID3/HSPB11/TACSTD2/BAX/CTSH 6 GO:0043410 positive regulation of MAPK cascade 10/436 480/18722 0.684187159562776 0.884008080132203 HMGB1/EZH2/PPIA/PRDX2/DDT/CD81/HRAS/RPS3/PHB2/ERP29 10 GO:0000959 mitochondrial RNA metabolic process 1/436 49/18722 0.685293529065546 0.884008080132203 TFAM 1 GO:0002762 negative regulation of myeloid leukocyte differentiation 1/436 49/18722 0.685293529065546 0.884008080132203 NME1 1 GO:0008038 neuron recognition 1/436 49/18722 0.685293529065546 0.884008080132203 CNTNAP2 1 GO:0008206 bile acid metabolic process 1/436 49/18722 0.685293529065546 0.884008080132203 SLC27A2 1 GO:0009066 aspartate family amino acid metabolic process 1/436 49/18722 0.685293529065546 0.884008080132203 MTAP 1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1/436 49/18722 0.685293529065546 0.884008080132203 TTK 1 GO:0018198 peptidyl-cysteine modification 1/436 49/18722 0.685293529065546 0.884008080132203 ZDHHC12 1 GO:0021695 cerebellar cortex development 1/436 49/18722 0.685293529065546 0.884008080132203 EZH2 1 GO:0030225 macrophage differentiation 1/436 49/18722 0.685293529065546 0.884008080132203 PARP1 1 GO:0032692 negative regulation of interleukin-1 production 1/436 49/18722 0.685293529065546 0.884008080132203 GSTP1 1 GO:0034332 adherens junction organization 1/436 49/18722 0.685293529065546 0.884008080132203 RDX 1 GO:0035088 establishment or maintenance of apical/basal cell polarity 1/436 49/18722 0.685293529065546 0.884008080132203 FAT1 1 GO:0042304 regulation of fatty acid biosynthetic process 1/436 49/18722 0.685293529065546 0.884008080132203 BRCA1 1 GO:0048168 regulation of neuronal synaptic plasticity 1/436 49/18722 0.685293529065546 0.884008080132203 HRAS 1 GO:0052372 modulation by symbiont of entry into host 1/436 49/18722 0.685293529065546 0.884008080132203 LY6E 1 GO:0061245 establishment or maintenance of bipolar cell polarity 1/436 49/18722 0.685293529065546 0.884008080132203 FAT1 1 GO:0070169 positive regulation of biomineral tissue development 1/436 49/18722 0.685293529065546 0.884008080132203 FBXO5 1 GO:0072666 establishment of protein localization to vacuole 1/436 49/18722 0.685293529065546 0.884008080132203 HSPA8 1 GO:0086009 membrane repolarization 1/436 49/18722 0.685293529065546 0.884008080132203 ATP1B3 1 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 1/436 49/18722 0.685293529065546 0.884008080132203 JUN 1 GO:1904894 positive regulation of receptor signaling pathway via STAT 1/436 49/18722 0.685293529065546 0.884008080132203 CENPJ 1 GO:1990573 potassium ion import across plasma membrane 1/436 49/18722 0.685293529065546 0.884008080132203 ATP1B3 1 GO:1990928 response to amino acid starvation 1/436 49/18722 0.685293529065546 0.884008080132203 EIF4EBP1 1 GO:0006576 cellular biogenic amine metabolic process 2/436 101/18722 0.685357473958514 0.884008080132203 PNKD/LY6E 2 GO:1903509 liposaccharide metabolic process 2/436 101/18722 0.685357473958514 0.884008080132203 PGAP2/BAX 2 GO:0048754 branching morphogenesis of an epithelial tube 3/436 151/18722 0.686595500243406 0.884939579765261 TACSTD2/PHB2/CTSH 3 GO:0071333 cellular response to glucose stimulus 3/436 151/18722 0.686595500243406 0.884939579765261 SLC29A1/NME1/MPC2 3 GO:0032496 response to lipopolysaccharide 7/436 343/18722 0.690254799618312 0.889058587311297 HMGB2/HMGB1/CDK4/JUN/PRDX2/GSTP1/HSPD1 7 GO:0035710 CD4-positive, alpha-beta T cell activation 2/436 102/18722 0.690559440726561 0.889058587311297 HMGB1/CD81 2 GO:0016125 sterol metabolic process 3/436 152/18722 0.690880996399328 0.889058587311297 FDPS/DHCR24/SQLE 3 GO:0030490 maturation of SSU-rRNA 1/436 50/18722 0.69264167994261 0.889058587311297 RPS21 1 GO:0043268 positive regulation of potassium ion transport 1/436 50/18722 0.69264167994261 0.889058587311297 ATP1B3 1 GO:0060425 lung morphogenesis 1/436 50/18722 0.69264167994261 0.889058587311297 CTSH 1 GO:0070231 T cell apoptotic process 1/436 50/18722 0.69264167994261 0.889058587311297 BAX 1 GO:0071709 membrane assembly 1/436 50/18722 0.69264167994261 0.889058587311297 EMP2 1 GO:0110151 positive regulation of biomineralization 1/436 50/18722 0.69264167994261 0.889058587311297 FBXO5 1 GO:1901570 fatty acid derivative biosynthetic process 1/436 50/18722 0.69264167994261 0.889058587311297 SLC25A1 1 GO:2000677 regulation of transcription regulatory region DNA binding 1/436 50/18722 0.69264167994261 0.889058587311297 PARP1 1 GO:0071331 cellular response to hexose stimulus 3/436 153/18722 0.695122374483893 0.891575651160462 SLC29A1/NME1/MPC2 3 GO:0120254 olefinic compound metabolic process 3/436 153/18722 0.695122374483893 0.891575651160462 GSTP1/PTGES3/GPX1 3 GO:0014013 regulation of gliogenesis 2/436 103/18722 0.695690462782935 0.891637645800616 EZH2/IDH2 2 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 2/436 103/18722 0.695690462782935 0.891637645800616 CENPJ/SUZ12 2 GO:0030856 regulation of epithelial cell differentiation 3/436 154/18722 0.699319717502744 0.892440591173818 EZH2/ID1/CCND1 3 GO:0071326 cellular response to monosaccharide stimulus 3/436 154/18722 0.699319717502744 0.892440591173818 SLC29A1/NME1/MPC2 3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/436 51/18722 0.699818641572057 0.892440591173818 NDUFA4 1 GO:0006636 unsaturated fatty acid biosynthetic process 1/436 51/18722 0.699818641572057 0.892440591173818 PTGES3 1 GO:0009948 anterior/posterior axis specification 1/436 51/18722 0.699818641572057 0.892440591173818 WLS 1 GO:0014009 glial cell proliferation 1/436 51/18722 0.699818641572057 0.892440591173818 IDH2 1 GO:0021872 forebrain generation of neurons 1/436 51/18722 0.699818641572057 0.892440591173818 ASPM 1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 1/436 51/18722 0.699818641572057 0.892440591173818 GSTP1 1 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 1/436 51/18722 0.699818641572057 0.892440591173818 HMGB1 1 GO:0045661 regulation of myoblast differentiation 1/436 51/18722 0.699818641572057 0.892440591173818 ID3 1 GO:0045668 negative regulation of osteoblast differentiation 1/436 51/18722 0.699818641572057 0.892440591173818 ID3 1 GO:0060043 regulation of cardiac muscle cell proliferation 1/436 51/18722 0.699818641572057 0.892440591173818 CDK1 1 GO:0071622 regulation of granulocyte chemotaxis 1/436 51/18722 0.699818641572057 0.892440591173818 C1QBP 1 GO:0051090 regulation of DNA-binding transcription factor activity 9/436 440/18722 0.699958505056469 0.892440591173818 EZH2/ID1/ID3/PPIA/CDKN2A/TFDP1/PRDX2/RPS3/PHB2 9 GO:0045621 positive regulation of lymphocyte differentiation 2/436 104/18722 0.700751014737454 0.892456099318562 PRKDC/XRCC6 2 GO:0046634 regulation of alpha-beta T cell activation 2/436 104/18722 0.700751014737454 0.892456099318562 HMGB1/CD81 2 GO:0060419 heart growth 2/436 104/18722 0.700751014737454 0.892456099318562 CDK1/PARP2 2 GO:0007015 actin filament organization 9/436 441/18722 0.702478108992189 0.894323707588942 DIAPH3/STMN1/ID1/EMP2/FAT1/ARPC5L/TACSTD2/PDLIM1/RDX 9 GO:0051147 regulation of muscle cell differentiation 3/436 155/18722 0.703473120077639 0.895258262235304 EZH2/PARP2/YBX1 3 GO:0030198 extracellular matrix organization 6/436 301/18722 0.70561706419966 0.895807691331074 COL14A1/CTSV/PRDX4/VWA1/SPINT2/CCDC80 6 GO:0000041 transition metal ion transport 2/436 105/18722 0.705741587583787 0.895807691331074 SLC39A1/SLC39A10 2 GO:0062207 regulation of pattern recognition receptor signaling pathway 2/436 105/18722 0.705741587583787 0.895807691331074 HMGB1/C1QBP 2 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 2/436 105/18722 0.705741587583787 0.895807691331074 ANLN/HRAS 2 GO:0010718 positive regulation of epithelial to mesenchymal transition 1/436 52/18722 0.706828393180143 0.895807691331074 EZH2 1 GO:0035176 social behavior 1/436 52/18722 0.706828393180143 0.895807691331074 CNTNAP2 1 GO:0035196 production of miRNAs involved in gene silencing by miRNA 1/436 52/18722 0.706828393180143 0.895807691331074 HNRNPA2B1 1 GO:0043277 apoptotic cell clearance 1/436 52/18722 0.706828393180143 0.895807691331074 HMGB1 1 GO:0045010 actin nucleation 1/436 52/18722 0.706828393180143 0.895807691331074 ARPC5L 1 GO:1903426 regulation of reactive oxygen species biosynthetic process 1/436 52/18722 0.706828393180143 0.895807691331074 HSPD1 1 GO:0051960 regulation of nervous system development 9/436 443/18722 0.707477117676168 0.895807691331074 HMGB2/EZH2/YWHAH/ID1/ASPM/NAP1L1/XRCC5/IDH2/DYNLT1 9 GO:0001764 neuron migration 3/436 156/18722 0.707582688059992 0.895807691331074 KIF20B/ASPM/BAX 3 GO:0009267 cellular response to starvation 3/436 156/18722 0.707582688059992 0.895807691331074 JUN/CTSV/HSPA8 3 GO:0035051 cardiocyte differentiation 3/436 156/18722 0.707582688059992 0.895807691331074 CDK1/CACYBP/PARP2 3 GO:0010498 proteasomal protein catabolic process 10/436 490/18722 0.708445048049379 0.895807691331074 PBK/UBE2C/UBE2S/SDF2L1/NUDT15/SVIP/PSMC3/ANAPC11/KLHL42/GPX1 10 GO:0043062 extracellular structure organization 6/436 302/18722 0.708604510134811 0.895807691331074 COL14A1/CTSV/PRDX4/VWA1/SPINT2/CCDC80 6 GO:0051056 regulation of small GTPase mediated signal transduction 6/436 302/18722 0.708604510134811 0.895807691331074 STMN1/FOXM1/NUP62/HRAS/DYNLT1/RDX 6 GO:0072001 renal system development 6/436 302/18722 0.708604510134811 0.895807691331074 CENPF/ID3/HSPB11/TACSTD2/BAX/CTSH 6 GO:0048863 stem cell differentiation 4/436 206/18722 0.71008517745463 0.895945229883827 TCOF1/PRKDC/XRCC5/TACSTD2 4 GO:0019882 antigen processing and presentation 2/436 106/18722 0.710662687682958 0.895945229883827 CTSV/CTSH 2 GO:0042116 macrophage activation 2/436 106/18722 0.710662687682958 0.895945229883827 HMGB1/HSPD1 2 GO:0046620 regulation of organ growth 2/436 106/18722 0.710662687682958 0.895945229883827 CDK1/PARP2 2 GO:0090263 positive regulation of canonical Wnt signaling pathway 2/436 106/18722 0.710662687682958 0.895945229883827 ASPM/WLS 2 GO:1905477 positive regulation of protein localization to membrane 2/436 106/18722 0.710662687682958 0.895945229883827 CD81/HRAS 2 GO:0034765 regulation of ion transmembrane transport 10/436 491/18722 0.710804997060716 0.895945229883827 YWHAH/CALM2/PPIF/ATP1B3/TMEM109/BAX/VDAC1/GSTO1/NDUFA4/PHB2 10 GO:0007162 negative regulation of cell adhesion 6/436 303/18722 0.711571336197967 0.895945229883827 HMGB1/CDKN2A/PRDX2/TACSTD2/SPINT2/RDX 6 GO:0001837 epithelial to mesenchymal transition 3/436 157/18722 0.711648538151467 0.895945229883827 HNRNPAB/EZH2/TCOF1 3 GO:0007030 Golgi organization 3/436 157/18722 0.711648538151467 0.895945229883827 CDK1/VRK1/LMAN1 3 GO:0001541 ovarian follicle development 1/436 53/18722 0.71367482170577 0.895945229883827 BAX 1 GO:0008347 glial cell migration 1/436 53/18722 0.71367482170577 0.895945229883827 IDH2 1 GO:0016925 protein sumoylation 1/436 53/18722 0.71367482170577 0.895945229883827 SAE1 1 GO:0031279 regulation of cyclase activity 1/436 53/18722 0.71367482170577 0.895945229883827 CALM2 1 GO:0034381 plasma lipoprotein particle clearance 1/436 53/18722 0.71367482170577 0.895945229883827 LRPAP1 1 GO:0043113 receptor clustering 1/436 53/18722 0.71367482170577 0.895945229883827 CD81 1 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1/436 53/18722 0.71367482170577 0.895945229883827 STMN1 1 GO:0045806 negative regulation of endocytosis 1/436 53/18722 0.71367482170577 0.895945229883827 LRPAP1 1 GO:1990090 cellular response to nerve growth factor stimulus 1/436 53/18722 0.71367482170577 0.895945229883827 ID1 1 GO:0045229 external encapsulating structure organization 6/436 304/18722 0.714517517194535 0.896287477757847 COL14A1/CTSV/PRDX4/VWA1/SPINT2/CCDC80 6 GO:0090596 sensory organ morphogenesis 5/436 256/18722 0.714748918478189 0.896287477757847 FAT1/HMGN1/BAX/C12orf57/EFEMP1 5 GO:0005976 polysaccharide metabolic process 2/436 107/18722 0.715514835785119 0.896287477757847 HMGB1/PTGES3 2 GO:0036503 ERAD pathway 2/436 107/18722 0.715514835785119 0.896287477757847 SDF2L1/SVIP 2 GO:0071868 cellular response to monoamine stimulus 2/436 107/18722 0.715514835785119 0.896287477757847 ID1/NSG1 2 GO:0071870 cellular response to catecholamine stimulus 2/436 107/18722 0.715514835785119 0.896287477757847 ID1/NSG1 2 GO:0002573 myeloid leukocyte differentiation 4/436 208/18722 0.717147907764771 0.897444108505606 PARP1/JUN/NME1/CD81 4 GO:0002832 negative regulation of response to biotic stimulus 2/436 108/18722 0.720298566088362 0.897444108505606 PRDX2/C1QBP 2 GO:0022037 metencephalon development 2/436 108/18722 0.720298566088362 0.897444108505606 EZH2/HNRNPD 2 GO:0034446 substrate adhesion-dependent cell spreading 2/436 108/18722 0.720298566088362 0.897444108505606 TACSTD2/C1QBP 2 GO:0098659 inorganic cation import across plasma membrane 2/436 108/18722 0.720298566088362 0.897444108505606 ATP1B3/SLC39A10 2 GO:0099587 inorganic ion import across plasma membrane 2/436 108/18722 0.720298566088362 0.897444108505606 ATP1B3/SLC39A10 2 GO:0006650 glycerophospholipid metabolic process 6/436 306/18722 0.720347861117697 0.897444108505606 PGP/IMPA2/PGAP2/CHPT1/DBI/PHB2 6 GO:0014888 striated muscle adaptation 1/436 54/18722 0.720361723936007 0.897444108505606 EZH2 1 GO:0030834 regulation of actin filament depolymerization 1/436 54/18722 0.720361723936007 0.897444108505606 RDX 1 GO:0031050 dsRNA processing 1/436 54/18722 0.720361723936007 0.897444108505606 HNRNPA2B1 1 GO:0032330 regulation of chondrocyte differentiation 1/436 54/18722 0.720361723936007 0.897444108505606 EFEMP1 1 GO:0043647 inositol phosphate metabolic process 1/436 54/18722 0.720361723936007 0.897444108505606 IMPA2 1 GO:0051703 biological process involved in intraspecies interaction between organisms 1/436 54/18722 0.720361723936007 0.897444108505606 CNTNAP2 1 GO:0070918 production of small RNA involved in gene silencing by RNA 1/436 54/18722 0.720361723936007 0.897444108505606 HNRNPA2B1 1 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 1/436 54/18722 0.720361723936007 0.897444108505606 JUN 1 GO:1902905 positive regulation of supramolecular fiber organization 4/436 209/18722 0.720631580677242 0.897454429511295 ID1/ARPC5L/RPS3/GPX1 4 GO:0060402 calcium ion transport into cytosol 3/436 160/18722 0.723585103080278 0.90080569255023 CALM2/BAX/GSTO1 3 GO:0002685 regulation of leukocyte migration 4/436 210/18722 0.724083511489295 0.900905373724339 HMGB1/DDT/CD81/C1QBP 4 GO:0045927 positive regulation of growth 5/436 259/18722 0.724190329563313 0.900905373724339 CDK1/PRKDC/EXOSC9/PARP2/DNPH1 5 GO:0060537 muscle tissue development 8/436 403/18722 0.725013186718256 0.901602118024768 CDK1/CENPF/CACYBP/PARP2/CSRP2/UQCC2/LY6E/GPX1 8 GO:0000768 syncytium formation by plasma membrane fusion 1/436 55/18722 0.726892808592312 0.901651925625532 CD81 1 GO:0003229 ventricular cardiac muscle tissue development 1/436 55/18722 0.726892808592312 0.901651925625532 LY6E 1 GO:0006414 translational elongation 1/436 55/18722 0.726892808592312 0.901651925625532 TUFM 1 GO:0010676 positive regulation of cellular carbohydrate metabolic process 1/436 55/18722 0.726892808592312 0.901651925625532 HMGB1 1 GO:0044091 membrane biogenesis 1/436 55/18722 0.726892808592312 0.901651925625532 EMP2 1 GO:0061614 pri-miRNA transcription by RNA polymerase II 1/436 55/18722 0.726892808592312 0.901651925625532 JUN 1 GO:0140253 cell-cell fusion 1/436 55/18722 0.726892808592312 0.901651925625532 CD81 1 GO:0090150 establishment of protein localization to membrane 5/436 260/18722 0.727287356090459 0.90181529408976 NSG1/ZDHHC12/HSP90AA1/HRAS/BAX 5 GO:0003014 renal system process 2/436 110/18722 0.729662971932872 0.903129024784157 EMP2/SNX5 2 GO:0009063 cellular amino acid catabolic process 2/436 110/18722 0.729662971932872 0.903129024784157 GCSH/ECHS1 2 GO:0032611 interleukin-1 beta production 2/436 110/18722 0.729662971932872 0.903129024784157 HMGB1/GSTP1 2 GO:0032651 regulation of interleukin-1 beta production 2/436 110/18722 0.729662971932872 0.903129024784157 HMGB1/GSTP1 2 GO:1905954 positive regulation of lipid localization 2/436 110/18722 0.729662971932872 0.903129024784157 DBI/HILPDA 2 GO:0006469 negative regulation of protein kinase activity 4/436 212/18722 0.730892343563193 0.904324425086662 NUP62/PPIA/CDKN2A/GSTP1 4 GO:0001658 branching involved in ureteric bud morphogenesis 1/436 56/18722 0.733271698368588 0.904572783198502 TACSTD2 1 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/436 56/18722 0.733271698368588 0.904572783198502 CADM1 1 GO:0002090 regulation of receptor internalization 1/436 56/18722 0.733271698368588 0.904572783198502 LRPAP1 1 GO:0006687 glycosphingolipid metabolic process 1/436 56/18722 0.733271698368588 0.904572783198502 BAX 1 GO:0046456 icosanoid biosynthetic process 1/436 56/18722 0.733271698368588 0.904572783198502 PTGES3 1 GO:0071385 cellular response to glucocorticoid stimulus 1/436 56/18722 0.733271698368588 0.904572783198502 GSTP1 1 GO:1904645 response to amyloid-beta 1/436 56/18722 0.733271698368588 0.904572783198502 PARP1 1 GO:1990089 response to nerve growth factor 1/436 56/18722 0.733271698368588 0.904572783198502 ID1 1 GO:0001938 positive regulation of endothelial cell proliferation 2/436 111/18722 0.734244775134416 0.904572783198502 HMGB2/HMGB1 2 GO:0071867 response to monoamine 2/436 111/18722 0.734244775134416 0.904572783198502 ID1/NSG1 2 GO:0071869 response to catecholamine 2/436 111/18722 0.734244775134416 0.904572783198502 ID1/NSG1 2 GO:2000146 negative regulation of cell motility 7/436 359/18722 0.734256835094091 0.904572783198502 HMGB1/DDT/GSTP1/IDH2/MARVELD3/TACSTD2/SPINT2 7 GO:0010976 positive regulation of neuron projection development 3/436 163/18722 0.735133373049048 0.905002727998307 EZH2/NME1/DYNLT1 3 GO:0071322 cellular response to carbohydrate stimulus 3/436 163/18722 0.735133373049048 0.905002727998307 SLC29A1/NME1/MPC2 3 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 3/436 164/18722 0.738897300536414 0.907775001225399 PBK/SVIP/RPS7 3 GO:0006949 syncytium formation 1/436 57/18722 0.739501931922177 0.907775001225399 CD81 1 GO:0010883 regulation of lipid storage 1/436 57/18722 0.739501931922177 0.907775001225399 HILPDA 1 GO:0030219 megakaryocyte differentiation 1/436 57/18722 0.739501931922177 0.907775001225399 HMGB2 1 GO:0050891 multicellular organismal water homeostasis 1/436 57/18722 0.739501931922177 0.907775001225399 STMN1 1 GO:0051155 positive regulation of striated muscle cell differentiation 1/436 57/18722 0.739501931922177 0.907775001225399 PARP2 1 GO:0051289 protein homotetramerization 1/436 57/18722 0.739501931922177 0.907775001225399 TK1 1 GO:1902017 regulation of cilium assembly 1/436 57/18722 0.739501931922177 0.907775001225399 VDAC3 1 GO:0050796 regulation of insulin secretion 3/436 165/18722 0.742618791137185 0.910035175995935 HADH/UQCC2/MPC2 3 GO:0031623 receptor internalization 2/436 113/18722 0.743210477712812 0.910035175995935 CD81/LRPAP1 2 GO:0044106 cellular amine metabolic process 2/436 113/18722 0.743210477712812 0.910035175995935 PNKD/LY6E 2 GO:0009612 response to mechanical stimulus 4/436 216/18722 0.744131608379008 0.910035175995935 CHEK1/CNTNAP2/CASP8AP2/JUN 4 GO:0050870 positive regulation of T cell activation 4/436 216/18722 0.744131608379008 0.910035175995935 HMGB1/CD81/RPS3/HSPD1 4 GO:0002237 response to molecule of bacterial origin 7/436 363/18722 0.744552060246251 0.910035175995935 HMGB2/HMGB1/CDK4/JUN/PRDX2/GSTP1/HSPD1 7 GO:0002768 immune response-regulating cell surface receptor signaling pathway 6/436 315/18722 0.745559214581349 0.910035175995935 CD81/HRAS/RPS3/BAX/SLC39A10/KHDRBS1 6 GO:0001954 positive regulation of cell-matrix adhesion 1/436 58/18722 0.745586965818879 0.910035175995935 EMP2 1 GO:0002763 positive regulation of myeloid leukocyte differentiation 1/436 58/18722 0.745586965818879 0.910035175995935 JUN 1 GO:0007405 neuroblast proliferation 1/436 58/18722 0.745586965818879 0.910035175995935 ASPM 1 GO:0010559 regulation of glycoprotein biosynthetic process 1/436 58/18722 0.745586965818879 0.910035175995935 ITM2C 1 GO:0010574 regulation of vascular endothelial growth factor production 1/436 58/18722 0.745586965818879 0.910035175995935 BRCA1 1 GO:0045604 regulation of epidermal cell differentiation 1/436 58/18722 0.745586965818879 0.910035175995935 EZH2 1 GO:0050432 catecholamine secretion 1/436 58/18722 0.745586965818879 0.910035175995935 LY6E 1 GO:0086065 cell communication involved in cardiac conduction 1/436 58/18722 0.745586965818879 0.910035175995935 CALM2 1 GO:2000649 regulation of sodium ion transmembrane transporter activity 1/436 58/18722 0.745586965818879 0.910035175995935 YWHAH 1 GO:0030307 positive regulation of cell growth 3/436 166/18722 0.746298043284518 0.910220147458056 EXOSC9/PARP2/DNPH1 3 GO:0007596 blood coagulation 4/436 217/18722 0.74736301728558 0.910220147458056 PPIA/VKORC1/PRDX2/LMAN1 4 GO:0070374 positive regulation of ERK1 and ERK2 cascade 4/436 217/18722 0.74736301728558 0.910220147458056 HMGB1/DDT/HRAS/PHB2 4 GO:0002286 T cell activation involved in immune response 2/436 114/18722 0.747595562674673 0.910220147458056 HMGB1/CD81 2 GO:0046660 female sex differentiation 2/436 114/18722 0.747595562674673 0.910220147458056 BRCA2/BAX 2 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2/436 114/18722 0.747595562674673 0.910220147458056 TTK/PARP1 2 GO:1904892 regulation of receptor signaling pathway via STAT 2/436 114/18722 0.747595562674673 0.910220147458056 CENPJ/SUZ12 2 GO:1903034 regulation of response to wounding 3/436 167/18722 0.749935262850135 0.912566231316425 HMGB1/PRDX2/HRAS 3 GO:0010506 regulation of autophagy 6/436 317/18722 0.750934004758688 0.912566231316425 HMGB1/SLC25A5/SVIP/SNX5/VDAC1/PHB2 6 GO:0030042 actin filament depolymerization 1/436 59/18722 0.751530176433054 0.912566231316425 RDX 1 GO:0032768 regulation of monooxygenase activity 1/436 59/18722 0.751530176433054 0.912566231316425 DHFR 1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 1/436 59/18722 0.751530176433054 0.912566231316425 SUZ12 1 GO:0051055 negative regulation of lipid biosynthetic process 1/436 59/18722 0.751530176433054 0.912566231316425 BRCA1 1 GO:0051568 histone H3-K4 methylation 1/436 59/18722 0.751530176433054 0.912566231316425 BRCA1 1 GO:0046916 cellular transition metal ion homeostasis 2/436 115/18722 0.751916273952648 0.912566231316425 MT2A/SLC39A10 2 GO:0071675 regulation of mononuclear cell migration 2/436 115/18722 0.751916273952648 0.912566231316425 HMGB1/C1QBP 2 GO:0051271 negative regulation of cellular component movement 7/436 367/18722 0.754563944842401 0.91513216498914 HMGB1/DDT/GSTP1/IDH2/MARVELD3/TACSTD2/SPINT2 7 GO:1903706 regulation of hemopoiesis 7/436 367/18722 0.754563944842401 0.91513216498914 HMGB2/HMGB1/PRKDC/JUN/PRDX2/NME1/XRCC6 7 GO:0030326 embryonic limb morphogenesis 2/436 116/18722 0.756173223514302 0.915902682710262 TMEM107/BAX 2 GO:0035113 embryonic appendage morphogenesis 2/436 116/18722 0.756173223514302 0.915902682710262 TMEM107/BAX 2 GO:0008202 steroid metabolic process 6/436 319/18722 0.756226215899503 0.915902682710262 YWHAH/FDPS/DHCR24/SLC27A2/SQLE/HINT2 6 GO:0031663 lipopolysaccharide-mediated signaling pathway 1/436 60/18722 0.757334861803851 0.915902682710262 PRDX2 1 GO:0055008 cardiac muscle tissue morphogenesis 1/436 60/18722 0.757334861803851 0.915902682710262 LY6E 1 GO:0060038 cardiac muscle cell proliferation 1/436 60/18722 0.757334861803851 0.915902682710262 CDK1 1 GO:0061951 establishment of protein localization to plasma membrane 1/436 60/18722 0.757334861803851 0.915902682710262 NSG1 1 GO:1903670 regulation of sprouting angiogenesis 1/436 60/18722 0.757334861803851 0.915902682710262 HMGB1 1 GO:0016311 dephosphorylation 8/436 417/18722 0.758736332889693 0.917274262912099 MASTL/PGP/IMPA2/CALM2/PPM1G/PPIA/CTDSPL/SLC39A10 8 GO:0014902 myotube differentiation 2/436 117/18722 0.760367029786421 0.918921901795424 CD81/GPX1 2 GO:0030199 collagen fibril organization 1/436 61/18722 0.763004243448558 0.918932448743999 COL14A1 1 GO:0030865 cortical cytoskeleton organization 1/436 61/18722 0.763004243448558 0.918932448743999 ANLN 1 GO:0034113 heterotypic cell-cell adhesion 1/436 61/18722 0.763004243448558 0.918932448743999 PERP 1 GO:0040014 regulation of multicellular organism growth 1/436 61/18722 0.763004243448558 0.918932448743999 CDK4 1 GO:0043030 regulation of macrophage activation 1/436 61/18722 0.763004243448558 0.918932448743999 HSPD1 1 GO:0050994 regulation of lipid catabolic process 1/436 61/18722 0.763004243448558 0.918932448743999 CDK4 1 GO:0071384 cellular response to corticosteroid stimulus 1/436 61/18722 0.763004243448558 0.918932448743999 GSTP1 1 GO:1905515 non-motile cilium assembly 1/436 61/18722 0.763004243448558 0.918932448743999 TMEM107 1 GO:0007599 hemostasis 4/436 222/18722 0.763054079414647 0.918932448743999 PPIA/VKORC1/PRDX2/LMAN1 4 GO:0050817 coagulation 4/436 222/18722 0.763054079414647 0.918932448743999 PPIA/VKORC1/PRDX2/LMAN1 4 GO:0042129 regulation of T cell proliferation 3/436 171/18722 0.764068176252791 0.919440665676486 HMGB1/CD81/RPS3 3 GO:0009308 amine metabolic process 2/436 118/18722 0.764498317024356 0.919440665676486 PNKD/LY6E 2 GO:0022612 gland morphogenesis 2/436 118/18722 0.764498317024356 0.919440665676486 BAX/PHB2 2 GO:0050920 regulation of chemotaxis 4/436 223/18722 0.766099816425632 0.919440665676486 HMGB1/DDT/GSTP1/C1QBP 4 GO:0048515 spermatid differentiation 3/436 172/18722 0.767498560439206 0.919440665676486 HMGB2/SRPK1/BAX 3 GO:0048736 appendage development 3/436 172/18722 0.767498560439206 0.919440665676486 TMEM107/BAX/SLC39A1 3 GO:0060173 limb development 3/436 172/18722 0.767498560439206 0.919440665676486 TMEM107/BAX/SLC39A1 3 GO:0007588 excretion 1/436 62/18722 0.768541468134075 0.919440665676486 SNX5 1 GO:0010573 vascular endothelial growth factor production 1/436 62/18722 0.768541468134075 0.919440665676486 BRCA1 1 GO:0032623 interleukin-2 production 1/436 62/18722 0.768541468134075 0.919440665676486 RPS3 1 GO:0032663 regulation of interleukin-2 production 1/436 62/18722 0.768541468134075 0.919440665676486 RPS3 1 GO:0032731 positive regulation of interleukin-1 beta production 1/436 62/18722 0.768541468134075 0.919440665676486 HMGB1 1 GO:0032757 positive regulation of interleukin-8 production 1/436 62/18722 0.768541468134075 0.919440665676486 HMGB1 1 GO:0045428 regulation of nitric oxide biosynthetic process 1/436 62/18722 0.768541468134075 0.919440665676486 HSP90AA1 1 GO:0048002 antigen processing and presentation of peptide antigen 1/436 62/18722 0.768541468134075 0.919440665676486 CTSV 1 GO:0060135 maternal process involved in female pregnancy 1/436 62/18722 0.768541468134075 0.919440665676486 CTSV 1 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 1/436 62/18722 0.768541468134075 0.919440665676486 TTK 1 GO:0060675 ureteric bud morphogenesis 1/436 62/18722 0.768541468134075 0.919440665676486 TACSTD2 1 GO:0010906 regulation of glucose metabolic process 2/436 119/18722 0.76856771470713 0.919440665676486 HMGB1/PGP 2 GO:0043270 positive regulation of ion transport 5/436 275/18722 0.770754478687247 0.921735314177743 CALM2/ATP1B3/BAX/GSTO1/NDUFA4 5 GO:0060562 epithelial tube morphogenesis 6/436 325/18722 0.771609538301194 0.922021218945565 KIF20B/TACSTD2/RPS7/SPINT2/PHB2/CTSH 6 GO:0008037 cell recognition 4/436 225/18722 0.772099722456015 0.922021218945565 CNTNAP2/CADM1/CD81/CCT5 4 GO:0050670 regulation of lymphocyte proliferation 4/436 225/18722 0.772099722456015 0.922021218945565 HMGB1/CD81/RPS3/SLC39A10 4 GO:0002761 regulation of myeloid leukocyte differentiation 2/436 120/18722 0.772575856957423 0.922021218945565 JUN/NME1 2 GO:0018108 peptidyl-tyrosine phosphorylation 7/436 375/18722 0.773740105792247 0.922021218945565 PBK/MELK/TTK/BAZ1B/CD81/SUZ12/EFEMP1 7 GO:0001756 somitogenesis 1/436 63/18722 0.77394960960747 0.922021218945565 PRKDC 1 GO:0022617 extracellular matrix disassembly 1/436 63/18722 0.77394960960747 0.922021218945565 CTSV 1 GO:0030239 myofibril assembly 1/436 63/18722 0.77394960960747 0.922021218945565 CSRP2 1 GO:0031343 positive regulation of cell killing 1/436 63/18722 0.77394960960747 0.922021218945565 CADM1 1 GO:0032233 positive regulation of actin filament bundle assembly 1/436 63/18722 0.77394960960747 0.922021218945565 ID1 1 GO:0072171 mesonephric tubule morphogenesis 1/436 63/18722 0.77394960960747 0.922021218945565 TACSTD2 1 GO:0048639 positive regulation of developmental growth 3/436 174/18722 0.774237605529834 0.922044159865623 CDK1/PRKDC/PARP2 3 GO:0110053 regulation of actin filament organization 5/436 277/18722 0.776131320812333 0.922547916063901 STMN1/ID1/ARPC5L/TACSTD2/RDX 5 GO:0002224 toll-like receptor signaling pathway 2/436 121/18722 0.776523381985634 0.922547916063901 HMGB1/HSPD1 2 GO:0002455 humoral immune response mediated by circulating immunoglobulin 2/436 121/18722 0.776523381985634 0.922547916063901 CD81/C1QBP 2 GO:0032944 regulation of mononuclear cell proliferation 4/436 227/18722 0.777978366001002 0.922547916063901 HMGB1/CD81/RPS3/SLC39A10 4 GO:0098657 import into cell 4/436 227/18722 0.777978366001002 0.922547916063901 SLC29A1/SLC27A2/ATP1B3/SLC39A10 4 GO:0030104 water homeostasis 1/436 64/18722 0.77923167028656 0.922547916063901 STMN1 1 GO:0030837 negative regulation of actin filament polymerization 1/436 64/18722 0.77923167028656 0.922547916063901 RDX 1 GO:0032507 maintenance of protein location in cell 1/436 64/18722 0.77923167028656 0.922547916063901 BARD1 1 GO:0045995 regulation of embryonic development 1/436 64/18722 0.77923167028656 0.922547916063901 CDK1 1 GO:0046854 phosphatidylinositol phosphate biosynthetic process 1/436 64/18722 0.77923167028656 0.922547916063901 IMPA2 1 GO:0046888 negative regulation of hormone secretion 1/436 64/18722 0.77923167028656 0.922547916063901 HADH 1 GO:0048247 lymphocyte chemotaxis 1/436 64/18722 0.77923167028656 0.922547916063901 CKLF 1 GO:0055002 striated muscle cell development 1/436 64/18722 0.77923167028656 0.922547916063901 CSRP2 1 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 1/436 64/18722 0.77923167028656 0.922547916063901 MPC2 1 GO:0080164 regulation of nitric oxide metabolic process 1/436 64/18722 0.77923167028656 0.922547916063901 HSP90AA1 1 GO:1903018 regulation of glycoprotein metabolic process 1/436 64/18722 0.77923167028656 0.922547916063901 ITM2C 1 GO:1903409 reactive oxygen species biosynthetic process 1/436 64/18722 0.77923167028656 0.922547916063901 HSPD1 1 GO:0050868 negative regulation of T cell activation 2/436 122/18722 0.780410931557202 0.923467716917679 HMGB1/PRDX2 2 GO:0018212 peptidyl-tyrosine modification 7/436 378/18722 0.780641412470666 0.923467716917679 PBK/MELK/TTK/BAZ1B/CD81/SUZ12/EFEMP1 7 GO:0050728 negative regulation of inflammatory response 3/436 176/18722 0.780816043945843 0.923467716917679 PBK/GSTP1/GPX1 3 GO:0030900 forebrain development 7/436 379/18722 0.782906946243109 0.924826147755725 RRM1/EZH2/CNTNAP2/ASPM/NME1/BAX/C12orf57 7 GO:0001649 osteoblast differentiation 4/436 229/18722 0.783736796724025 0.924826147755725 FBXO5/ID3/RBMX/RRBP1 4 GO:0071695 anatomical structure maturation 4/436 229/18722 0.783736796724025 0.924826147755725 TYMS/FBXO5/BRCA2/CNTNAP2 4 GO:0002720 positive regulation of cytokine production involved in immune response 1/436 65/18722 0.784390582911442 0.924826147755725 CD81 1 GO:0015909 long-chain fatty acid transport 1/436 65/18722 0.784390582911442 0.924826147755725 SLC27A2 1 GO:0033692 cellular polysaccharide biosynthetic process 1/436 65/18722 0.784390582911442 0.924826147755725 PTGES3 1 GO:0045682 regulation of epidermis development 1/436 65/18722 0.784390582911442 0.924826147755725 EZH2 1 GO:0060389 pathway-restricted SMAD protein phosphorylation 1/436 65/18722 0.784390582911442 0.924826147755725 TTK 1 GO:0061512 protein localization to cilium 1/436 65/18722 0.784390582911442 0.924826147755725 TMEM107 1 GO:0016197 endosomal transport 4/436 230/18722 0.786571276824525 0.926588893535018 NSG1/SNX5/PLEKHJ1/VPS29 4 GO:0006109 regulation of carbohydrate metabolic process 3/436 178/18722 0.787235973376443 0.926588893535018 HMGB1/PGP/PGAM1 3 GO:0009266 response to temperature stimulus 3/436 178/18722 0.787235973376443 0.926588893535018 PSIP1/HSP90AA1/HSPD1 3 GO:0035265 organ growth 3/436 178/18722 0.787235973376443 0.926588893535018 CDK1/PARP2/LY6E 3 GO:0035725 sodium ion transmembrane transport 3/436 178/18722 0.787235973376443 0.926588893535018 YWHAH/ATP1B3/SLC20A1 3 GO:0030193 regulation of blood coagulation 1/436 66/18722 0.789429212157871 0.92809704758138 PRDX2 1 GO:0042093 T-helper cell differentiation 1/436 66/18722 0.789429212157871 0.92809704758138 HMGB1 1 GO:0071300 cellular response to retinoic acid 1/436 66/18722 0.789429212157871 0.92809704758138 PHB2 1 GO:0007018 microtubule-based movement 7/436 382/18722 0.789599324363174 0.92809704758138 KIF23/KIF20B/KPNB1/HSPB11/KIF22/HSPA8/DYNLT1 7 GO:0006941 striated muscle contraction 3/436 179/18722 0.790387172432959 0.928704927608727 CALM2/C12orf57/GSTO1 3 GO:1990778 protein localization to cell periphery 6/436 333/18722 0.790981117894887 0.929084633857363 EMP2/NSG1/ATP1B3/CD81/HRAS/RDX 6 GO:2000027 regulation of animal organ morphogenesis 2/436 125/18722 0.791720187949437 0.929404847373537 TACSTD2/PHB2 2 GO:0006644 phospholipid metabolic process 7/436 383/18722 0.791795502440352 0.929404847373537 PGP/IMPA2/FDPS/PGAP2/CHPT1/DBI/PHB2 7 GO:0062012 regulation of small molecule metabolic process 6/436 334/18722 0.793312094460344 0.92985877590175 BRCA1/HMGB1/PGP/PARP1/ENO1/PGAM1 6 GO:0015698 inorganic anion transport 3/436 180/18722 0.793499562741975 0.92985877590175 SLC20A1/VDAC3/VDAC1 3 GO:0014706 striated muscle tissue development 7/436 384/18722 0.793974440631931 0.92985877590175 CDK1/CENPF/CACYBP/PARP2/UQCC2/LY6E/GPX1 7 GO:0006520 cellular amino acid metabolic process 5/436 284/18722 0.794191015021954 0.92985877590175 DHFR/GMPS/MTAP/GCSH/ECHS1 5 GO:0072659 protein localization to plasma membrane 5/436 284/18722 0.794191015021954 0.92985877590175 EMP2/NSG1/ATP1B3/CD81/RDX 5 GO:0035914 skeletal muscle cell differentiation 1/436 67/18722 0.794350356213358 0.92985877590175 UQCC2 1 GO:0046635 positive regulation of alpha-beta T cell activation 1/436 67/18722 0.794350356213358 0.92985877590175 CD81 1 GO:0070527 platelet aggregation 1/436 67/18722 0.794350356213358 0.92985877590175 PPIA 1 GO:0032874 positive regulation of stress-activated MAPK cascade 2/436 126/18722 0.795374307044237 0.930739852479119 HMGB1/HRAS 2 GO:0045766 positive regulation of angiogenesis 3/436 181/18722 0.796573425330001 0.931354213136947 BRCA1/HMGB1/CTSH 3 GO:1904018 positive regulation of vasculature development 3/436 181/18722 0.796573425330001 0.931354213136947 BRCA1/HMGB1/CTSH 3 GO:0030048 actin filament-based movement 2/436 127/18722 0.798971695723939 0.931354213136947 EMP2/MYH10 2 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 1/436 68/18722 0.799156748316867 0.931354213136947 HMGB1 1 GO:0009247 glycolipid biosynthetic process 1/436 68/18722 0.799156748316867 0.931354213136947 PGAP2 1 GO:0031640 killing of cells of other organism 1/436 68/18722 0.799156748316867 0.931354213136947 HMGN2 1 GO:0034394 protein localization to cell surface 1/436 68/18722 0.799156748316867 0.931354213136947 EMP2 1 GO:0042698 ovulation cycle 1/436 68/18722 0.799156748316867 0.931354213136947 PCNA 1 GO:0042987 amyloid precursor protein catabolic process 1/436 68/18722 0.799156748316867 0.931354213136947 DHCR24 1 GO:0046637 regulation of alpha-beta T cell differentiation 1/436 68/18722 0.799156748316867 0.931354213136947 HMGB1 1 GO:1900046 regulation of hemostasis 1/436 68/18722 0.799156748316867 0.931354213136947 PRDX2 1 GO:1901016 regulation of potassium ion transmembrane transporter activity 1/436 68/18722 0.799156748316867 0.931354213136947 ATP1B3 1 GO:0001952 regulation of cell-matrix adhesion 2/436 128/18722 0.802513007105704 0.933337726192931 EMP2/CDKN2A 2 GO:0032612 interleukin-1 production 2/436 128/18722 0.802513007105704 0.933337726192931 HMGB1/GSTP1 2 GO:0032652 regulation of interleukin-1 production 2/436 128/18722 0.802513007105704 0.933337726192931 HMGB1/GSTP1 2 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 2/436 128/18722 0.802513007105704 0.933337726192931 HMGB1/HRAS 2 GO:0048738 cardiac muscle tissue development 4/436 236/18722 0.802961143259141 0.933337726192931 CDK1/CACYBP/PARP2/LY6E 4 GO:0002287 alpha-beta T cell activation involved in immune response 1/436 69/18722 0.80385105826293 0.933337726192931 HMGB1 1 GO:0002293 alpha-beta T cell differentiation involved in immune response 1/436 69/18722 0.80385105826293 0.933337726192931 HMGB1 1 GO:0019226 transmission of nerve impulse 1/436 69/18722 0.80385105826293 0.933337726192931 CNTNAP2 1 GO:0045665 negative regulation of neuron differentiation 1/436 69/18722 0.80385105826293 0.933337726192931 ASPM 1 GO:0045669 positive regulation of osteoblast differentiation 1/436 69/18722 0.80385105826293 0.933337726192931 FBXO5 1 GO:0050805 negative regulation of synaptic transmission 1/436 69/18722 0.80385105826293 0.933337726192931 PNKD 1 GO:0033673 negative regulation of kinase activity 4/436 237/18722 0.805591400208908 0.935041980418391 NUP62/PPIA/CDKN2A/GSTP1 4 GO:0002548 monocyte chemotaxis 1/436 70/18722 0.808435893871002 0.937437400167172 HMGB1 1 GO:0060415 muscle tissue morphogenesis 1/436 70/18722 0.808435893871002 0.937437400167172 LY6E 1 GO:0051896 regulation of protein kinase B signaling 3/436 185/18722 0.808489338616057 0.937437400167172 HSP90AA1/C1QBP/GPX1 3 GO:0040013 negative regulation of locomotion 7/436 391/18722 0.808748092245651 0.937437400167172 HMGB1/DDT/GSTP1/IDH2/MARVELD3/TACSTD2/SPINT2 7 GO:1903039 positive regulation of leukocyte cell-cell adhesion 4/436 239/18722 0.810766471581044 0.93909335222425 HMGB1/CD81/RPS3/HSPD1 4 GO:0046486 glycerolipid metabolic process 7/436 392/18722 0.810790785753774 0.93909335222425 PGP/IMPA2/PGAP2/CHPT1/DBI/PHB2/GPX1 7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 3/436 186/18722 0.811374894716079 0.93909335222425 NUP62/SLC20A1/WLS 3 GO:0006612 protein targeting to membrane 2/436 131/18722 0.81280701264456 0.93909335222425 ZDHHC12/HRAS 2 GO:0006661 phosphatidylinositol biosynthetic process 2/436 131/18722 0.81280701264456 0.93909335222425 IMPA2/PGAP2 2 GO:0003208 cardiac ventricle morphogenesis 1/436 71/18722 0.812913802420875 0.93909335222425 LY6E 1 GO:0032722 positive regulation of chemokine production 1/436 71/18722 0.812913802420875 0.93909335222425 HMGB1 1 GO:0050818 regulation of coagulation 1/436 71/18722 0.812913802420875 0.93909335222425 PRDX2 1 GO:0071230 cellular response to amino acid stimulus 1/436 71/18722 0.812913802420875 0.93909335222425 HNRNPD 1 GO:0072078 nephron tubule morphogenesis 1/436 71/18722 0.812913802420875 0.93909335222425 TACSTD2 1 GO:0010632 regulation of epithelial cell migration 5/436 292/18722 0.813414956204773 0.939356013038901 HMGB1/EMP2/MARVELD3/TACSTD2/CTSH 5 GO:0030336 negative regulation of cell migration 6/436 344/18722 0.815537698569943 0.941293262981006 HMGB1/DDT/GSTP1/IDH2/MARVELD3/TACSTD2 6 GO:0045667 regulation of osteoblast differentiation 2/436 132/18722 0.816130548822571 0.941293262981006 FBXO5/ID3 2 GO:0048839 inner ear development 3/436 188/18722 0.817035985343358 0.941293262981006 CCNA2/ANP32B/MCM2 3 GO:0000271 polysaccharide biosynthetic process 1/436 72/18722 0.817287272054916 0.941293262981006 PTGES3 1 GO:0001707 mesoderm formation 1/436 72/18722 0.817287272054916 0.941293262981006 WLS 1 GO:0002534 cytokine production involved in inflammatory response 1/436 72/18722 0.817287272054916 0.941293262981006 EZH2 1 GO:0043903 regulation of biological process involved in symbiotic interaction 1/436 72/18722 0.817287272054916 0.941293262981006 LY6E 1 GO:1900015 regulation of cytokine production involved in inflammatory response 1/436 72/18722 0.817287272054916 0.941293262981006 EZH2 1 GO:0016358 dendrite development 4/436 243/18722 0.820779621657918 0.943633784237209 EZH2/YWHAH/ID1/DYNLT1 4 GO:0032732 positive regulation of interleukin-1 production 1/436 73/18722 0.821558733147895 0.943633784237209 HMGB1 1 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 1/436 73/18722 0.821558733147895 0.943633784237209 MPC2 1 GO:0050848 regulation of calcium-mediated signaling 1/436 73/18722 0.821558733147895 0.943633784237209 CALM2 1 GO:0051937 catecholamine transport 1/436 73/18722 0.821558733147895 0.943633784237209 LY6E 1 GO:0061035 regulation of cartilage development 1/436 73/18722 0.821558733147895 0.943633784237209 EFEMP1 1 GO:0072088 nephron epithelium morphogenesis 1/436 73/18722 0.821558733147895 0.943633784237209 TACSTD2 1 GO:0050890 cognition 5/436 296/18722 0.822476169858228 0.943633784237209 FEN1/CNTNAP2/JUN/C12orf57/VDAC1 5 GO:0009566 fertilization 3/436 190/18722 0.822552401657207 0.943633784237209 CDK1/BAX/CCT5 3 GO:0030041 actin filament polymerization 3/436 190/18722 0.822552401657207 0.943633784237209 DIAPH3/ARPC5L/RDX 3 GO:0008277 regulation of G protein-coupled receptor signaling pathway 2/436 134/18722 0.822619833475223 0.943633784237209 STMN1/DYNLT1 2 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 2/436 134/18722 0.822619833475223 0.943633784237209 PBK/SVIP 2 GO:0048332 mesoderm morphogenesis 1/436 74/18722 0.825730559645161 0.946633741720193 WLS 1 GO:0002687 positive regulation of leukocyte migration 2/436 135/18722 0.825786881075062 0.946633741720193 HMGB1/C1QBP 2 GO:0010720 positive regulation of cell development 5/436 298/18722 0.826872249945119 0.947561352559019 ASPM/PRKDC/NAP1L1/XRCC5/C1QBP 5 GO:0098876 vesicle-mediated transport to the plasma membrane 2/436 136/18722 0.828903062034384 0.948388140052994 NSG1/VPS29 2 GO:0002292 T cell differentiation involved in immune response 1/436 75/18722 0.829805070369888 0.948388140052994 HMGB1 1 GO:0008088 axo-dendritic transport 1/436 75/18722 0.829805070369888 0.948388140052994 HSPA8 1 GO:0033077 T cell differentiation in thymus 1/436 75/18722 0.829805070369888 0.948388140052994 PRKDC 1 GO:0034121 regulation of toll-like receptor signaling pathway 1/436 75/18722 0.829805070369888 0.948388140052994 HMGB1 1 GO:0045913 positive regulation of carbohydrate metabolic process 1/436 75/18722 0.829805070369888 0.948388140052994 HMGB1 1 GO:0048662 negative regulation of smooth muscle cell proliferation 1/436 75/18722 0.829805070369888 0.948388140052994 GSTP1 1 GO:0061333 renal tubule morphogenesis 1/436 75/18722 0.829805070369888 0.948388140052994 TACSTD2 1 GO:0007565 female pregnancy 3/436 193/18722 0.830561134730994 0.948936148272408 EMP2/CTSV/C1QBP 3 GO:0055123 digestive system development 2/436 137/18722 0.831969021151844 0.949912050439925 TYMS/WLS 2 GO:0060048 cardiac muscle contraction 2/436 137/18722 0.831969021151844 0.949912050439925 CALM2/GSTO1 2 GO:0014855 striated muscle cell proliferation 1/436 76/18722 0.833784530300104 0.950087918784343 CDK1 1 GO:0032720 negative regulation of tumor necrosis factor production 1/436 76/18722 0.833784530300104 0.950087918784343 GSTP1 1 GO:0043536 positive regulation of blood vessel endothelial cell migration 1/436 76/18722 0.833784530300104 0.950087918784343 HMGB1 1 GO:0045685 regulation of glial cell differentiation 1/436 76/18722 0.833784530300104 0.950087918784343 CDK1 1 GO:0072028 nephron morphogenesis 1/436 76/18722 0.833784530300104 0.950087918784343 TACSTD2 1 GO:2000379 positive regulation of reactive oxygen species metabolic process 1/436 76/18722 0.833784530300104 0.950087918784343 GSTP1 1 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 4/436 249/18722 0.834978177327273 0.950194000109449 NUP62/GSTP1/SLC20A1/WLS 4 GO:0035107 appendage morphogenesis 2/436 138/18722 0.834985400853975 0.950194000109449 TMEM107/BAX 2 GO:0035108 limb morphogenesis 2/436 138/18722 0.834985400853975 0.950194000109449 TMEM107/BAX 2 GO:0055076 transition metal ion homeostasis 2/436 138/18722 0.834985400853975 0.950194000109449 MT2A/SLC39A10 2 GO:0030073 insulin secretion 3/436 195/18722 0.835726653064692 0.950722197170079 HADH/UQCC2/MPC2 3 GO:0071560 cellular response to transforming growth factor beta stimulus 4/436 250/18722 0.837251157341071 0.951394010039312 ID1/PARP1/JUN/NREP 4 GO:0021675 nerve development 1/436 77/18722 0.837671151816201 0.951394010039312 CTSV 1 GO:0031016 pancreas development 1/436 77/18722 0.837671151816201 0.951394010039312 WLS 1 GO:0048644 muscle organ morphogenesis 1/436 77/18722 0.837671151816201 0.951394010039312 LY6E 1 GO:0045664 regulation of neuron differentiation 3/436 196/18722 0.838258260667106 0.951394010039312 YWHAH/ASPM/NREP 3 GO:0071674 mononuclear cell migration 3/436 196/18722 0.838258260667106 0.951394010039312 HMGB1/CKLF/C1QBP 3 GO:0090276 regulation of peptide hormone secretion 3/436 196/18722 0.838258260667106 0.951394010039312 HADH/UQCC2/MPC2 3 GO:0030177 positive regulation of Wnt signaling pathway 2/436 140/18722 0.840871978436541 0.952951737289639 ASPM/WLS 2 GO:0009064 glutamine family amino acid metabolic process 1/436 78/18722 0.841467095919615 0.952951737289639 GMPS 1 GO:0032024 positive regulation of insulin secretion 1/436 78/18722 0.841467095919615 0.952951737289639 MPC2 1 GO:0043537 negative regulation of blood vessel endothelial cell migration 1/436 78/18722 0.841467095919615 0.952951737289639 HMGB1 1 GO:0070373 negative regulation of ERK1 and ERK2 cascade 1/436 78/18722 0.841467095919615 0.952951737289639 GSTP1 1 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 1/436 78/18722 0.841467095919615 0.952951737289639 GSTP1 1 GO:0032956 regulation of actin cytoskeleton organization 6/436 357/18722 0.841574982217314 0.952951737289639 STMN1/ID1/ARPC5L/HRAS/TACSTD2/RDX 6 GO:0048167 regulation of synaptic plasticity 3/436 198/18722 0.843220748520425 0.954025654794072 YWHAH/NSG1/HRAS 3 GO:0048284 organelle fusion 2/436 141/18722 0.843743447220407 0.954025654794072 CDK1/BAX 2 GO:0050921 positive regulation of chemotaxis 2/436 141/18722 0.843743447220407 0.954025654794072 HMGB1/C1QBP 2 GO:1903038 negative regulation of leukocyte cell-cell adhesion 2/436 141/18722 0.843743447220407 0.954025654794072 HMGB1/PRDX2 2 GO:0008654 phospholipid biosynthetic process 4/436 253/18722 0.84391368764209 0.954025654794072 IMPA2/FDPS/PGAP2/CHPT1 4 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 1/436 79/18722 0.845174473423318 0.9551362379168 HMGN2 1 GO:0046467 membrane lipid biosynthetic process 2/436 142/18722 0.846567877977991 0.956395913514154 HACD3/PGAP2 2 GO:0002791 regulation of peptide secretion 3/436 200/18722 0.848051042524507 0.956555933408935 HADH/UQCC2/MPC2 3 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 7/436 412/18722 0.848198579254894 0.956555933408935 PBK/UBE2C/UBE2S/SVIP/PSMC3/ANAPC11/KLHL42 7 GO:0007611 learning or memory 4/436 255/18722 0.848226963271639 0.956555933408935 FEN1/CNTNAP2/JUN/VDAC1 4 GO:0051924 regulation of calcium ion transport 4/436 255/18722 0.848226963271639 0.956555933408935 CALM2/BAX/VDAC1/GSTO1 4 GO:0001570 vasculogenesis 1/436 80/18722 0.848795346114807 0.956555933408935 EMP2 1 GO:0007422 peripheral nervous system development 1/436 80/18722 0.848795346114807 0.956555933408935 CDK1 1 GO:0071229 cellular response to acid chemical 1/436 80/18722 0.848795346114807 0.956555933408935 HNRNPD 1 GO:0062013 positive regulation of small molecule metabolic process 2/436 143/18722 0.8493458979319 0.956555933408935 HMGB1/ENO1 2 GO:0022604 regulation of cell morphogenesis 5/436 309/18722 0.84949750192277 0.956555933408935 PRKDC/MYH10/TACSTD2/C1QBP/RDX 5 GO:0070372 regulation of ERK1 and ERK2 cascade 5/436 309/18722 0.84949750192277 0.956555933408935 HMGB1/DDT/GSTP1/HRAS/PHB2 5 GO:0071559 response to transforming growth factor beta 4/436 256/18722 0.850345662395345 0.957079167654906 ID1/PARP1/JUN/NREP 4 GO:0051047 positive regulation of secretion 5/436 310/18722 0.851427623402851 0.957079167654906 PPIA/MYH10/MPC2/SNX5/WLS 5 GO:0001558 regulation of cell growth 7/436 414/18722 0.851589665267777 0.957079167654906 TMEM97/EXOSC9/PARP2/CDKN2A/DNPH1/ENO1/CHPT1 7 GO:0001890 placenta development 2/436 144/18722 0.852078130675784 0.957079167654906 CTSV/SPINT2 2 GO:0033135 regulation of peptidyl-serine phosphorylation 2/436 144/18722 0.852078130675784 0.957079167654906 HSP90AA1/BAX 2 GO:0001960 negative regulation of cytokine-mediated signaling pathway 1/436 81/18722 0.852331727892189 0.957079167654906 GSTP1 1 GO:0014032 neural crest cell development 1/436 81/18722 0.852331727892189 0.957079167654906 TCOF1 1 GO:0051149 positive regulation of muscle cell differentiation 1/436 81/18722 0.852331727892189 0.957079167654906 PARP2 1 GO:0031589 cell-substrate adhesion 6/436 363/18722 0.85255105815748 0.957079167654906 ID1/EMP2/CDKN2A/TACSTD2/C1QBP/CCDC80 6 GO:0090087 regulation of peptide transport 3/436 202/18722 0.852751680420008 0.957079167654906 HADH/UQCC2/MPC2 3 GO:0031348 negative regulation of defense response 4/436 258/18722 0.854508167012633 0.958289929873924 PBK/GSTP1/C1QBP/GPX1 4 GO:0042593 glucose homeostasis 4/436 258/18722 0.854508167012633 0.958289929873924 SLC29A1/NUCKS1/NME1/MPC2 4 GO:0006643 membrane lipid metabolic process 3/436 203/18722 0.855054172562735 0.958289929873924 HACD3/PGAP2/BAX 3 GO:0001892 embryonic placenta development 1/436 82/18722 0.855785585874003 0.958289929873924 SPINT2 1 GO:0001910 regulation of leukocyte mediated cytotoxicity 1/436 82/18722 0.855785585874003 0.958289929873924 CADM1 1 GO:0007032 endosome organization 1/436 82/18722 0.855785585874003 0.958289929873924 PLEKHJ1 1 GO:0008543 fibroblast growth factor receptor signaling pathway 1/436 82/18722 0.855785585874003 0.958289929873924 SHCBP1 1 GO:0033500 carbohydrate homeostasis 4/436 259/18722 0.856552368384387 0.958835620204513 SLC29A1/NUCKS1/NME1/MPC2 4 GO:0045580 regulation of T cell differentiation 2/436 146/18722 0.857407709746334 0.959167216217695 HMGB1/PRDX2 2 GO:0048813 dendrite morphogenesis 2/436 146/18722 0.857407709746334 0.959167216217695 YWHAH/ID1 2 GO:0051091 positive regulation of DNA-binding transcription factor activity 4/436 260/18722 0.85857213420148 0.960156777198591 PPIA/TFDP1/RPS3/PHB2 4 GO:0043367 CD4-positive, alpha-beta T cell differentiation 1/436 83/18722 0.859158841483388 0.96018696584023 HMGB1 1 GO:0061053 somite development 1/436 83/18722 0.859158841483388 0.96018696584023 PRKDC 1 GO:0060041 retina development in camera-type eye 2/436 147/18722 0.860006283624341 0.960821087305475 RRM1/BAX 2 GO:0010660 regulation of muscle cell apoptotic process 1/436 84/18722 0.862453371507168 0.962614677176674 CDKN2A 1 GO:0015844 monoamine transport 1/436 84/18722 0.862453371507168 0.962614677176674 LY6E 1 GO:0032370 positive regulation of lipid transport 1/436 84/18722 0.862453371507168 0.962614677176674 DBI 1 GO:0050900 leukocyte migration 6/436 369/18722 0.862898561113788 0.962798362010214 HMGB1/CKLF/PPIA/DDT/CD81/C1QBP 6 GO:0042060 wound healing 7/436 422/18722 0.864547908904181 0.964010786214412 HMGB1/PPIA/VKORC1/PRDX2/HRAS/LMAN1/GPX1 7 GO:1905039 carboxylic acid transmembrane transport 2/436 149/18722 0.865074037249839 0.964010786214412 SLC25A1/MPC2 2 GO:0030433 ubiquitin-dependent ERAD pathway 1/436 85/18722 0.865671009130458 0.964010786214412 SVIP 1 GO:0032092 positive regulation of protein binding 1/436 85/18722 0.865671009130458 0.964010786214412 RAN 1 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 1/436 85/18722 0.865671009130458 0.964010786214412 SUZ12 1 GO:0097006 regulation of plasma lipoprotein particle levels 1/436 85/18722 0.865671009130458 0.964010786214412 LRPAP1 1 GO:1903825 organic acid transmembrane transport 2/436 150/18722 0.867544418631322 0.965317121992974 SLC25A1/MPC2 2 GO:0014031 mesenchymal cell development 1/436 86/18722 0.868813544947334 0.965317121992974 TCOF1 1 GO:0015908 fatty acid transport 1/436 86/18722 0.868813544947334 0.965317121992974 SLC27A2 1 GO:0035023 regulation of Rho protein signal transduction 1/436 86/18722 0.868813544947334 0.965317121992974 STMN1 1 GO:0046928 regulation of neurotransmitter secretion 1/436 86/18722 0.868813544947334 0.965317121992974 PNKD 1 GO:0048864 stem cell development 1/436 86/18722 0.868813544947334 0.965317121992974 TCOF1 1 GO:0060761 negative regulation of response to cytokine stimulus 1/436 86/18722 0.868813544947334 0.965317121992974 GSTP1 1 GO:0055067 monovalent inorganic cation homeostasis 2/436 151/18722 0.869973263173441 0.966292737438678 ATP1B3/SNX5 2 GO:0007029 endoplasmic reticulum organization 1/436 87/18722 0.871882727948137 0.96707437762263 LMAN1 1 GO:0150104 transport across blood-brain barrier 1/436 87/18722 0.871882727948137 0.96707437762263 SLC29A1 1 GO:1901606 alpha-amino acid catabolic process 1/436 87/18722 0.871882727948137 0.96707437762263 GCSH 1 GO:0051092 positive regulation of NF-kappaB transcription factor activity 2/436 152/18722 0.872361160063763 0.96707437762263 PPIA/RPS3 2 GO:0043491 protein kinase B signaling 3/436 211/18722 0.872368172177803 0.96707437762263 HSP90AA1/C1QBP/GPX1 3 GO:0046474 glycerophospholipid biosynthetic process 3/436 211/18722 0.872368172177803 0.96707437762263 IMPA2/PGAP2/CHPT1 3 GO:0001894 tissue homeostasis 4/436 268/18722 0.873874621609286 0.968294901389156 BARD1/FH/BAX/CTSH 4 GO:0007338 single fertilization 2/436 153/18722 0.874708693647602 0.968294901389156 CDK1/CCT5 2 GO:0007260 tyrosine phosphorylation of STAT protein 1/436 88/18722 0.874880266483936 0.968294901389156 SUZ12 1 GO:0010232 vascular transport 1/436 88/18722 0.874880266483936 0.968294901389156 SLC29A1 1 GO:0050829 defense response to Gram-negative bacterium 1/436 88/18722 0.874880266483936 0.968294901389156 HMGB2 1 GO:0001505 regulation of neurotransmitter levels 3/436 213/18722 0.876401062370086 0.969096108559739 GCHFR/SLC29A1/PNKD 3 GO:0043583 ear development 3/436 213/18722 0.876401062370086 0.969096108559739 CCNA2/ANP32B/MCM2 3 GO:0016049 cell growth 8/436 482/18722 0.876918427378995 0.969096108559739 TMEM97/EXOSC9/PARP2/CDKN2A/HSP90AA1/DNPH1/ENO1/CHPT1 8 GO:0007605 sensory perception of sound 2/436 154/18722 0.877016443333719 0.969096108559739 BIRC5/GPX1 2 GO:0008360 regulation of cell shape 2/436 154/18722 0.877016443333719 0.969096108559739 MYH10/RDX 2 GO:0010657 muscle cell apoptotic process 1/436 89/18722 0.877807829208687 0.969346205991311 CDKN2A 1 GO:0014910 regulation of smooth muscle cell migration 1/436 89/18722 0.877807829208687 0.969346205991311 GSTP1 1 GO:0006665 sphingolipid metabolic process 2/436 155/18722 0.879284983507001 0.970005982287195 HACD3/BAX 2 GO:0007519 skeletal muscle tissue development 2/436 155/18722 0.879284983507001 0.970005982287195 UQCC2/GPX1 2 GO:0010970 transport along microtubule 2/436 155/18722 0.879284983507001 0.970005982287195 HSPB11/HSPA8 2 GO:0031669 cellular response to nutrient levels 3/436 215/18722 0.880320733955616 0.970005982287195 JUN/CTSV/HSPA8 3 GO:0006400 tRNA modification 1/436 90/18722 0.880667045999596 0.970005982287195 TPRKB 1 GO:0045638 negative regulation of myeloid cell differentiation 1/436 90/18722 0.880667045999596 0.970005982287195 NME1 1 GO:0070664 negative regulation of leukocyte proliferation 1/436 90/18722 0.880667045999596 0.970005982287195 GSTP1 1 GO:0099175 regulation of postsynapse organization 1/436 90/18722 0.880667045999596 0.970005982287195 HSPA8 1 GO:0007517 muscle organ development 5/436 327/18722 0.881210456213779 0.970239268032865 CENPF/ID3/UQCC2/LY6E/GPX1 5 GO:0046631 alpha-beta T cell activation 2/436 156/18722 0.881514883447871 0.970239268032865 HMGB1/CD81 2 GO:0002683 negative regulation of immune system process 7/436 434/18722 0.882238750828899 0.970239268032865 HMGB1/PRKDC/PRDX2/DDT/NME1/C1QBP/GPX1 7 GO:0001657 ureteric bud development 1/436 91/18722 0.883459508856196 0.970239268032865 TACSTD2 1 GO:0002065 columnar/cuboidal epithelial cell differentiation 1/436 91/18722 0.883459508856196 0.970239268032865 TYMS 1 GO:0002275 myeloid cell activation involved in immune response 1/436 91/18722 0.883459508856196 0.970239268032865 HMGB1 1 GO:0014033 neural crest cell differentiation 1/436 91/18722 0.883459508856196 0.970239268032865 TCOF1 1 GO:0072080 nephron tubule development 1/436 91/18722 0.883459508856196 0.970239268032865 TACSTD2 1 GO:0098661 inorganic anion transmembrane transport 1/436 91/18722 0.883459508856196 0.970239268032865 SLC20A1 1 GO:0051250 negative regulation of lymphocyte activation 2/436 157/18722 0.883706707258147 0.970239268032865 HMGB1/PRDX2 2 GO:0008154 actin polymerization or depolymerization 3/436 217/18722 0.884129673925396 0.970331220445638 DIAPH3/ARPC5L/RDX 3 GO:0050863 regulation of T cell activation 5/436 329/18722 0.884356084620668 0.970331220445638 HMGB1/PRDX2/CD81/RPS3/HSPD1 5 GO:0070509 calcium ion import 1/436 92/18722 0.886186772778621 0.971274982407804 VDAC1 1 GO:0072163 mesonephric epithelium development 1/436 92/18722 0.886186772778621 0.971274982407804 TACSTD2 1 GO:0072164 mesonephric tubule development 1/436 92/18722 0.886186772778621 0.971274982407804 TACSTD2 1 GO:0045785 positive regulation of cell adhesion 7/436 437/18722 0.886348577650491 0.971274982407804 HMGB1/EMP2/CD81/RPS3/C1QBP/HSPD1/CCDC80 7 GO:0046488 phosphatidylinositol metabolic process 2/436 159/18722 0.88797835659948 0.972317812026321 IMPA2/PGAP2 2 GO:0019217 regulation of fatty acid metabolic process 1/436 93/18722 0.888850356625563 0.972317812026321 BRCA1 1 GO:0045185 maintenance of protein location 1/436 93/18722 0.888850356625563 0.972317812026321 BARD1 1 GO:0060349 bone morphogenesis 1/436 93/18722 0.888850356625563 0.972317812026321 TMEM107 1 GO:0060993 kidney morphogenesis 1/436 93/18722 0.888850356625563 0.972317812026321 TACSTD2 1 GO:0050727 regulation of inflammatory response 6/436 386/18722 0.889000576020568 0.972317812026321 PBK/DDT/GSTP1/CD81/HSPD1/GPX1 6 GO:0044706 multi-multicellular organism process 3/436 220/18722 0.88964085621813 0.972708023481327 EMP2/CTSV/C1QBP 3 GO:0035637 multicellular organismal signaling 2/436 160/18722 0.890059283859217 0.972855496311237 CNTNAP2/CALM2 2 GO:0001738 morphogenesis of a polarized epithelium 1/436 94/18722 0.891451743952379 0.97313742713987 FAT1 1 GO:0030316 osteoclast differentiation 1/436 94/18722 0.891451743952379 0.97313742713987 CD81 1 GO:0048704 embryonic skeletal system morphogenesis 1/436 94/18722 0.891451743952379 0.97313742713987 SLC39A1 1 GO:0061326 renal tubule development 1/436 94/18722 0.891451743952379 0.97313742713987 TACSTD2 1 GO:0043542 endothelial cell migration 4/436 279/18722 0.892572212572372 0.973140839484439 HMGB1/ID1/EMP2/GPX1 4 GO:0048709 oligodendrocyte differentiation 1/436 95/18722 0.893992383829809 0.973140839484439 GSTP1 1 GO:0050764 regulation of phagocytosis 1/436 95/18722 0.893992383829809 0.973140839484439 HMGB1 1 GO:1901379 regulation of potassium ion transmembrane transport 1/436 95/18722 0.893992383829809 0.973140839484439 ATP1B3 1 GO:0021953 central nervous system neuron differentiation 2/436 162/18722 0.894114057343 0.973140839484439 HSP90AA1/C12orf57 2 GO:0021700 developmental maturation 4/436 280/18722 0.894145505638411 0.973140839484439 TYMS/FBXO5/BRCA2/CNTNAP2 4 GO:1903037 regulation of leukocyte cell-cell adhesion 5/436 336/18722 0.894811149818091 0.973140839484439 HMGB1/PRDX2/CD81/RPS3/HSPD1 5 GO:0001823 mesonephros development 1/436 96/18722 0.896473691643745 0.973140839484439 TACSTD2 1 GO:0002718 regulation of cytokine production involved in immune response 1/436 96/18722 0.896473691643745 0.973140839484439 CD81 1 GO:0003073 regulation of systemic arterial blood pressure 1/436 96/18722 0.896473691643745 0.973140839484439 EMP2 1 GO:0015914 phospholipid transport 1/436 96/18722 0.896473691643745 0.973140839484439 DBI 1 GO:0035282 segmentation 1/436 96/18722 0.896473691643745 0.973140839484439 PRKDC 1 GO:0042632 cholesterol homeostasis 1/436 96/18722 0.896473691643745 0.973140839484439 TMEM97 1 GO:1901655 cellular response to ketone 1/436 96/18722 0.896473691643745 0.973140839484439 CDK4 1 GO:1903532 positive regulation of secretion by cell 4/436 282/18722 0.897231648616698 0.973140839484439 PPIA/MYH10/MPC2/WLS 4 GO:0050806 positive regulation of synaptic transmission 2/436 164/18722 0.898029610603492 0.973140839484439 NSG1/ZDHHC12 2 GO:0050769 positive regulation of neurogenesis 3/436 225/18722 0.898307164269755 0.973140839484439 ASPM/NAP1L1/XRCC5 3 GO:0006721 terpenoid metabolic process 1/436 97/18722 0.898897049876502 0.973140839484439 FDPS 1 GO:0010596 negative regulation of endothelial cell migration 1/436 97/18722 0.898897049876502 0.973140839484439 HMGB1 1 GO:0014909 smooth muscle cell migration 1/436 97/18722 0.898897049876502 0.973140839484439 GSTP1 1 GO:0035335 peptidyl-tyrosine dephosphorylation 1/436 97/18722 0.898897049876502 0.973140839484439 PGP 1 GO:0043255 regulation of carbohydrate biosynthetic process 1/436 97/18722 0.898897049876502 0.973140839484439 PGP 1 GO:0055092 sterol homeostasis 1/436 97/18722 0.898897049876502 0.973140839484439 TMEM97 1 GO:0070167 regulation of biomineral tissue development 1/436 97/18722 0.898897049876502 0.973140839484439 FBXO5 1 GO:0070252 actin-mediated cell contraction 1/436 97/18722 0.898897049876502 0.973140839484439 EMP2 1 GO:0007286 spermatid development 2/436 165/18722 0.899936491823937 0.973140839484439 HMGB2/SRPK1 2 GO:0032635 interleukin-6 production 2/436 165/18722 0.899936491823937 0.973140839484439 HMGB1/HSPD1 2 GO:0032675 regulation of interleukin-6 production 2/436 165/18722 0.899936491823937 0.973140839484439 HMGB1/HSPD1 2 GO:0022409 positive regulation of cell-cell adhesion 4/436 284/18722 0.900238522089897 0.973140839484439 HMGB1/CD81/RPS3/HSPD1 4 GO:0022407 regulation of cell-cell adhesion 7/436 448/18722 0.900405505824314 0.973140839484439 HMGB1/PRDX2/CD81/RPS3/SPINT2/RDX/HSPD1 7 GO:0002367 cytokine production involved in immune response 1/436 98/18722 0.901263808869997 0.973140839484439 CD81 1 GO:0043473 pigmentation 1/436 98/18722 0.901263808869997 0.973140839484439 BAX 1 GO:0061337 cardiac conduction 1/436 98/18722 0.901263808869997 0.973140839484439 CALM2 1 GO:0060538 skeletal muscle organ development 2/436 166/18722 0.901810131440272 0.973140839484439 UQCC2/GPX1 2 GO:0032970 regulation of actin filament-based process 6/436 396/18722 0.902295546027673 0.973140839484439 STMN1/ID1/ARPC5L/HRAS/TACSTD2/RDX 6 GO:0010717 regulation of epithelial to mesenchymal transition 1/436 99/18722 0.903575287571279 0.973140839484439 EZH2 1 GO:0021510 spinal cord development 1/436 99/18722 0.903575287571279 0.973140839484439 SUZ12 1 GO:0030838 positive regulation of actin filament polymerization 1/436 99/18722 0.903575287571279 0.973140839484439 ARPC5L 1 GO:0031341 regulation of cell killing 1/436 99/18722 0.903575287571279 0.973140839484439 CADM1 1 GO:0033209 tumor necrosis factor-mediated signaling pathway 1/436 99/18722 0.903575287571279 0.973140839484439 GSTP1 1 GO:0060291 long-term synaptic potentiation 1/436 99/18722 0.903575287571279 0.973140839484439 NSG1 1 GO:0110149 regulation of biomineralization 1/436 99/18722 0.903575287571279 0.973140839484439 FBXO5 1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 2/436 167/18722 0.903651038938334 0.973140839484439 CADM1/FAT1 2 GO:0071356 cellular response to tumor necrosis factor 3/436 229/18722 0.904794626974712 0.973656719451379 BRCA1/GSTP1/RPS3 3 GO:0003012 muscle system process 7/436 452/18722 0.905138644548301 0.973656719451379 EZH2/CALM2/PARP1/PARP2/ENO1/C12orf57/GSTO1 7 GO:0099173 postsynapse organization 2/436 168/18722 0.905459718168428 0.973656719451379 ZDHHC12/HSPA8 2 GO:0006641 triglyceride metabolic process 1/436 100/18722 0.905832774260799 0.973656719451379 GPX1 1 GO:0051588 regulation of neurotransmitter transport 1/436 100/18722 0.905832774260799 0.973656719451379 PNKD 1 GO:0060079 excitatory postsynaptic potential 1/436 100/18722 0.905832774260799 0.973656719451379 SLC29A1 1 GO:0031214 biomineral tissue development 2/436 169/18722 0.907236667330925 0.974860321206515 FBXO5/SLC20A1 2 GO:0050830 defense response to Gram-positive bacterium 1/436 101/18722 0.908037527263822 0.975069962467706 HMGB2 1 GO:0007259 receptor signaling pathway via JAK-STAT 2/436 170/18722 0.908982378965586 0.975069962467706 CENPJ/SUZ12 2 GO:0016236 macroautophagy 4/436 291/18722 0.91016100367675 0.975069962467706 SLC25A5/SNX5/VDAC1/PHB2 4 GO:0060485 mesenchyme development 4/436 291/18722 0.91016100367675 0.975069962467706 HNRNPAB/EZH2/TCOF1/DPPA4 4 GO:0032677 regulation of interleukin-8 production 1/436 102/18722 0.910190775645379 0.975069962467706 HMGB1 1 GO:0034308 primary alcohol metabolic process 1/436 102/18722 0.910190775645379 0.975069962467706 AKR7A2 1 GO:0045833 negative regulation of lipid metabolic process 1/436 102/18722 0.910190775645379 0.975069962467706 BRCA1 1 GO:0030833 regulation of actin filament polymerization 2/436 171/18722 0.910697339944436 0.975069962467706 ARPC5L/RDX 2 GO:0046890 regulation of lipid biosynthetic process 2/436 171/18722 0.910697339944436 0.975069962467706 BRCA1/CDK4 2 GO:0110148 biomineralization 2/436 171/18722 0.910697339944436 0.975069962467706 FBXO5/SLC20A1 2 GO:0043087 regulation of GTPase activity 5/436 348/18722 0.910842095514135 0.975069962467706 STMN1/EZH2/HRAS/DYNLT1/RDX 5 GO:1901342 regulation of vasculature development 5/436 348/18722 0.910842095514135 0.975069962467706 BRCA1/HMGB1/ID1/EMP2/CTSH 5 GO:0002027 regulation of heart rate 1/436 103/18722 0.912293719889128 0.975102726772461 CALM2 1 GO:0030004 cellular monovalent inorganic cation homeostasis 1/436 103/18722 0.912293719889128 0.975102726772461 ATP1B3 1 GO:0030148 sphingolipid biosynthetic process 1/436 103/18722 0.912293719889128 0.975102726772461 HACD3 1 GO:0032637 interleukin-8 production 1/436 103/18722 0.912293719889128 0.975102726772461 HMGB1 1 GO:0090277 positive regulation of peptide hormone secretion 1/436 103/18722 0.912293719889128 0.975102726772461 MPC2 1 GO:0010469 regulation of signaling receptor activity 2/436 173/18722 0.914036929064949 0.976081637901397 LY6E/LRPAP1 2 GO:0010959 regulation of metal ion transport 6/436 406/18722 0.914201760412474 0.976081637901397 YWHAH/CALM2/ATP1B3/BAX/VDAC1/GSTO1 6 GO:0048661 positive regulation of smooth muscle cell proliferation 1/436 104/18722 0.914347532560504 0.976081637901397 JUN 1 GO:1901890 positive regulation of cell junction assembly 1/436 104/18722 0.914347532560504 0.976081637901397 CNTNAP2 1 GO:0030072 peptide hormone secretion 3/436 236/18722 0.915254284075279 0.976441992743247 HADH/UQCC2/MPC2 3 GO:0048762 mesenchymal cell differentiation 3/436 236/18722 0.915254284075279 0.976441992743247 HNRNPAB/EZH2/TCOF1 3 GO:0031346 positive regulation of cell projection organization 5/436 353/18722 0.916864942393894 0.977338978350643 EZH2/ANLN/NME1/HRAS/DYNLT1 5 GO:0050954 sensory perception of mechanical stimulus 2/436 175/18722 0.917259216251869 0.977338978350643 BIRC5/GPX1 2 GO:1905475 regulation of protein localization to membrane 2/436 175/18722 0.917259216251869 0.977338978350643 CD81/HRAS 2 GO:0015711 organic anion transport 5/436 354/18722 0.918025693099107 0.977338978350643 SLC29A1/SLC25A5/SLC25A1/MPC2/SLC25A6 5 GO:0002062 chondrocyte differentiation 1/436 106/18722 0.918312317728526 0.977338978350643 EFEMP1 1 GO:0002793 positive regulation of peptide secretion 1/436 106/18722 0.918312317728526 0.977338978350643 MPC2 1 GO:0099565 chemical synaptic transmission, postsynaptic 1/436 106/18722 0.918312317728526 0.977338978350643 SLC29A1 1 GO:0010634 positive regulation of epithelial cell migration 2/436 176/18722 0.918827528577226 0.977338978350643 HMGB1/CTSH 2 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 5/436 355/18722 0.919172161558445 0.977338978350643 ID1/TTK/PARP1/JUN/NREP 5 GO:0007229 integrin-mediated signaling pathway 1/436 107/18722 0.920225501520445 0.977338978350643 EMP2 1 GO:0010927 cellular component assembly involved in morphogenesis 1/436 107/18722 0.920225501520445 0.977338978350643 CSRP2 1 GO:0031532 actin cytoskeleton reorganization 1/436 107/18722 0.920225501520445 0.977338978350643 HRAS 1 GO:0042303 molting cycle 1/436 107/18722 0.920225501520445 0.977338978350643 SNRPE 1 GO:0042633 hair cycle 1/436 107/18722 0.920225501520445 0.977338978350643 SNRPE 1 GO:0098739 import across plasma membrane 2/436 177/18722 0.920367892466023 0.977338978350643 ATP1B3/SLC39A10 2 GO:0001818 negative regulation of cytokine production 5/436 357/18722 0.921422802379705 0.977961186084296 HMGB1/EZH2/GSTP1/SUZ12/C1QBP 5 GO:0060047 heart contraction 3/436 241/18722 0.922074170724953 0.977961186084296 CALM2/GSTO1/GPX1 3 GO:0006958 complement activation, classical pathway 1/436 108/18722 0.92209397755252 0.977961186084296 C1QBP 1 GO:0033138 positive regulation of peptidyl-serine phosphorylation 1/436 108/18722 0.92209397755252 0.977961186084296 HSP90AA1 1 GO:0042063 gliogenesis 4/436 301/18722 0.922816154818779 0.978384371107096 CDK1/EZH2/GSTP1/IDH2 4 GO:0001936 regulation of endothelial cell proliferation 2/436 179/18722 0.923366558377866 0.978384371107096 HMGB2/HMGB1 2 GO:0002790 peptide secretion 3/436 242/18722 0.923376549147321 0.978384371107096 HADH/UQCC2/MPC2 3 GO:0043266 regulation of potassium ion transport 1/436 109/18722 0.923918788221216 0.978384371107096 ATP1B3 1 GO:0072009 nephron epithelium development 1/436 109/18722 0.923918788221216 0.978384371107096 TACSTD2 1 GO:0002698 negative regulation of immune effector process 1/436 110/18722 0.925700951673402 0.978747670133252 PRKDC 1 GO:0014812 muscle cell migration 1/436 110/18722 0.925700951673402 0.978747670133252 GSTP1 1 GO:0048259 regulation of receptor-mediated endocytosis 1/436 110/18722 0.925700951673402 0.978747670133252 LRPAP1 1 GO:0006898 receptor-mediated endocytosis 3/436 244/18722 0.925921815141353 0.978747670133252 CD81/AP2S1/LRPAP1 3 GO:0008361 regulation of cell size 2/436 181/18722 0.926258724839018 0.978747670133252 CDK4/RDX 2 GO:0097696 receptor signaling pathway via STAT 2/436 181/18722 0.926258724839018 0.978747670133252 CENPJ/SUZ12 2 GO:1905952 regulation of lipid localization 2/436 181/18722 0.926258724839018 0.978747670133252 DBI/HILPDA 2 GO:0006814 sodium ion transport 3/436 245/18722 0.927165219743774 0.9793941697103 YWHAH/ATP1B3/SLC20A1 3 GO:0015718 monocarboxylic acid transport 1/436 111/18722 0.927441462369211 0.9793941697103 MPC2 1 GO:0032102 negative regulation of response to external stimulus 6/436 420/18722 0.92874660107246 0.980284062604209 PBK/PRDX2/DDT/GSTP1/C1QBP/GPX1 6 GO:0002526 acute inflammatory response 1/436 112/18722 0.929141291631853 0.980284062604209 GSTP1 1 GO:0046632 alpha-beta T cell differentiation 1/436 112/18722 0.929141291631853 0.980284062604209 HMGB1 1 GO:2001257 regulation of cation channel activity 2/436 184/18722 0.930404748716679 0.980829104073007 CALM2/GSTO1 2 GO:0001578 microtubule bundle formation 1/436 113/18722 0.930801388184702 0.980829104073007 PRC1 1 GO:0044344 cellular response to fibroblast growth factor stimulus 1/436 113/18722 0.930801388184702 0.980829104073007 SHCBP1 1 GO:0071347 cellular response to interleukin-1 1/436 113/18722 0.930801388184702 0.980829104073007 RBMX 1 GO:0045926 negative regulation of growth 3/436 249/18722 0.931949908955193 0.981152634966621 MT2A/CDKN2A/ENO1 3 GO:0046883 regulation of hormone secretion 3/436 249/18722 0.931949908955193 0.981152634966621 HADH/UQCC2/MPC2 3 GO:0007041 lysosomal transport 1/436 114/18722 0.932422678675941 0.981152634966621 HSPA8 1 GO:1901800 positive regulation of proteasomal protein catabolic process 1/436 114/18722 0.932422678675941 0.981152634966621 PSMC3 1 GO:0008217 regulation of blood pressure 2/436 186/18722 0.933045443036044 0.981152634966621 EMP2/SNX5 2 GO:0003015 heart process 3/436 251/18722 0.934232380355683 0.981152634966621 CALM2/GSTO1/GPX1 3 GO:0002695 negative regulation of leukocyte activation 2/436 187/18722 0.934330002674957 0.981152634966621 HMGB1/PRDX2 2 GO:0008064 regulation of actin polymerization or depolymerization 2/436 187/18722 0.934330002674957 0.981152634966621 ARPC5L/RDX 2 GO:0070588 calcium ion transmembrane transport 4/436 312/18722 0.934871241221655 0.981152634966621 CALM2/BAX/VDAC1/GSTO1 4 GO:0045017 glycerolipid biosynthetic process 3/436 252/18722 0.935347002765658 0.981152634966621 IMPA2/PGAP2/CHPT1 3 GO:0061448 connective tissue development 3/436 252/18722 0.935347002765658 0.981152634966621 TYMS/CDK4/EFEMP1 3 GO:0006720 isoprenoid metabolic process 1/436 116/18722 0.935552440753464 0.981152634966621 FDPS 1 GO:0021782 glial cell development 1/436 116/18722 0.935552440753464 0.981152634966621 GSTP1 1 GO:0030308 negative regulation of cell growth 2/436 188/18722 0.93559122866777 0.981152634966621 CDKN2A/ENO1 2 GO:0030832 regulation of actin filament length 2/436 188/18722 0.93559122866777 0.981152634966621 ARPC5L/RDX 2 GO:0007159 leukocyte cell-cell adhesion 5/436 371/18722 0.935683888548757 0.981152634966621 HMGB1/PRDX2/CD81/RPS3/HSPD1 5 GO:0034612 response to tumor necrosis factor 3/436 253/18722 0.936444202547141 0.981649880519169 BRCA1/GSTP1/RPS3 3 GO:0060249 anatomical structure homeostasis 4/436 314/18722 0.936870746321443 0.981698316280978 BARD1/FH/BAX/CTSH 4 GO:0072676 lymphocyte migration 1/436 117/18722 0.937062659813525 0.981698316280978 CKLF 1 GO:0051216 cartilage development 2/436 190/18722 0.938045221745195 0.982127908394191 TYMS/EFEMP1 2 GO:0099111 microtubule-based transport 2/436 190/18722 0.938045221745195 0.982127908394191 HSPB11/HSPA8 2 GO:0007613 memory 1/436 118/18722 0.938537568726253 0.982343623642395 FEN1 1 GO:0042110 T cell activation 7/436 487/18722 0.938951648596646 0.982477312087555 HMGB1/PRKDC/PRDX2/CD81/RPS3/BAX/HSPD1 7 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3/436 256/18722 0.939633622296466 0.982891145761944 TTK/PARP1/NREP 3 GO:0030217 T cell differentiation 3/436 257/18722 0.94066347612928 0.983162515413719 HMGB1/PRKDC/PRDX2 3 GO:0042391 regulation of membrane potential 6/436 434/18722 0.941078179636696 0.983162515413719 YWHAH/SLC29A1/PARP1/JUN/ATP1B3/BAX 6 GO:0048675 axon extension 1/436 120/18722 0.941384731841978 0.983162515413719 HSP90AA1 1 GO:0071774 response to fibroblast growth factor 1/436 120/18722 0.941384731841978 0.983162515413719 SHCBP1 1 GO:0001935 endothelial cell proliferation 2/436 193/18722 0.941560708096285 0.983162515413719 HMGB2/HMGB1 2 GO:0007204 positive regulation of cytosolic calcium ion concentration 4/436 319/18722 0.941628329241042 0.983162515413719 HMGB1/CALM2/BAX/GSTO1 4 GO:0050777 negative regulation of immune response 2/436 194/18722 0.942689871209988 0.983162515413719 C1QBP/GPX1 2 GO:0001704 formation of primary germ layer 1/436 121/18722 0.942758576424114 0.983162515413719 WLS 1 GO:0003206 cardiac chamber morphogenesis 1/436 121/18722 0.942758576424114 0.983162515413719 LY6E 1 GO:0048706 embryonic skeletal system development 1/436 121/18722 0.942758576424114 0.983162515413719 SLC39A1 1 GO:0019730 antimicrobial humoral response 1/436 122/18722 0.944100292497394 0.98426256565134 HMGN2 1 GO:0003231 cardiac ventricle development 1/436 123/18722 0.945410629727025 0.985030024474165 LY6E 1 GO:0030168 platelet activation 1/436 123/18722 0.945410629727025 0.985030024474165 PPIA 1 GO:0043588 skin development 3/436 263/18722 0.946508897396118 0.985764640071751 STMN1/DHCR24/PTGES3 3 GO:0007368 determination of left/right symmetry 1/436 124/18722 0.946690320325392 0.985764640071751 TMEM107 1 GO:0015833 peptide transport 3/436 264/18722 0.947429564715732 0.986235083901601 HADH/UQCC2/MPC2 3 GO:1904375 regulation of protein localization to cell periphery 1/436 125/18722 0.947940079457456 0.986467216444808 HRAS 1 GO:0031929 TOR signaling 1/436 126/18722 0.949160605636762 0.987132010660302 EIF4EBP1 1 GO:0010975 regulation of neuron projection development 6/436 445/18722 0.949395946058473 0.987132010660302 EZH2/YWHAH/ID1/NME1/ITM2C/DYNLT1 6 GO:0009952 anterior/posterior pattern specification 2/436 201/18722 0.95003268257199 0.987132010660302 PRKDC/WLS 2 GO:0035270 endocrine system development 1/436 127/18722 0.95035258111226 0.987132010660302 LY6E 1 GO:0048565 digestive tract development 1/436 127/18722 0.95035258111226 0.987132010660302 TYMS 1 GO:0048638 regulation of developmental growth 4/436 330/18722 0.950966515300082 0.987132010660302 CDK1/PRKDC/CDK4/PARP2 4 GO:0019722 calcium-mediated signaling 2/436 202/18722 0.95100549259351 0.987132010660302 CALM2/GSTO1 2 GO:0006639 acylglycerol metabolic process 1/436 128/18722 0.95151667224617 0.987132010660302 GPX1 1 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 1/436 128/18722 0.95151667224617 0.987132010660302 NREP 1 GO:0003002 regionalization 4/436 331/18722 0.951743716486237 0.987132010660302 PRKDC/TMEM107/HSPB11/WLS 4 GO:0019216 regulation of lipid metabolic process 4/436 331/18722 0.951743716486237 0.987132010660302 BRCA1/CDK4/CD81/PHB2 4 GO:0006638 neutral lipid metabolic process 1/436 129/18722 0.952653529883078 0.987448114271417 GPX1 1 GO:0007498 mesoderm development 1/436 129/18722 0.952653529883078 0.987448114271417 WLS 1 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 1/436 130/18722 0.953763789710485 0.987448114271417 LMAN1 1 GO:0006956 complement activation 1/436 130/18722 0.953763789710485 0.987448114271417 C1QBP 1 GO:0030534 adult behavior 1/436 130/18722 0.953763789710485 0.987448114271417 CNTNAP2 1 GO:0060348 bone development 2/436 205/18722 0.953816740852384 0.987448114271417 TMEM107/VKORC1 2 GO:0051962 positive regulation of nervous system development 3/436 272/18722 0.954281727358592 0.987448114271417 ASPM/NAP1L1/XRCC5 3 GO:0008016 regulation of heart contraction 2/436 206/18722 0.954719119144871 0.987448114271417 CALM2/GSTO1 2 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 1/436 131/18722 0.954848072610992 0.987448114271417 NREP 1 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 3/436 273/18722 0.955077115687861 0.987448114271417 CADM1/FAT1/CLDN7 3 GO:0035264 multicellular organism growth 1/436 132/18722 0.955906985006324 0.987448114271417 CDK4 1 GO:0006836 neurotransmitter transport 2/436 208/18722 0.956473611817657 0.987448114271417 SLC29A1/PNKD 2 GO:0009855 determination of bilateral symmetry 1/436 133/18722 0.956941119193373 0.987448114271417 TMEM107 1 GO:0010565 regulation of cellular ketone metabolic process 1/436 133/18722 0.956941119193373 0.987448114271417 BRCA1 1 GO:0010595 positive regulation of endothelial cell migration 1/436 133/18722 0.956941119193373 0.987448114271417 HMGB1 1 GO:0046887 positive regulation of hormone secretion 1/436 133/18722 0.956941119193373 0.987448114271417 MPC2 1 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 1/436 133/18722 0.956941119193373 0.987448114271417 PSMC3 1 GO:0001508 action potential 1/436 134/18722 0.957951053672457 0.987817702516883 YWHAH 1 GO:0009799 specification of symmetry 1/436 134/18722 0.957951053672457 0.987817702516883 TMEM107 1 GO:0050866 negative regulation of cell activation 2/436 210/18722 0.958163017772132 0.987817702516883 HMGB1/PRDX2 2 GO:0030100 regulation of endocytosis 2/436 211/18722 0.958984021079255 0.988070323220097 AP2S1/LRPAP1 2 GO:0050807 regulation of synapse organization 2/436 211/18722 0.958984021079255 0.988070323220097 TUBB/HSPA8 2 GO:0045765 regulation of angiogenesis 4/436 342/18722 0.959576953975619 0.988124469602439 BRCA1/HMGB1/EMP2/CTSH 4 GO:0072073 kidney epithelium development 1/436 136/18722 0.959900570441542 0.988124469602439 TACSTD2 1 GO:0099024 plasma membrane invagination 1/436 136/18722 0.959900570441542 0.988124469602439 AURKB 1 GO:0010977 negative regulation of neuron projection development 1/436 137/18722 0.960841243598084 0.9884996422144 ITM2C 1 GO:0060078 regulation of postsynaptic membrane potential 1/436 137/18722 0.960841243598084 0.9884996422144 SLC29A1 1 GO:0007224 smoothened signaling pathway 1/436 138/18722 0.961759899384537 0.989148145919768 HSPB11 1 GO:0007601 visual perception 2/436 215/18722 0.96211641601722 0.989218286890945 TACSTD2/EFEMP1 2 GO:0006936 muscle contraction 4/436 347/18722 0.962734201398587 0.989474312010588 CALM2/ENO1/C12orf57/GSTO1 4 GO:0061564 axon development 6/436 467/18722 0.962942211542802 0.989474312010588 DHFR/STMN1/HSP90AA1/NREP/C12orf57/DYNLT1 6 GO:0050803 regulation of synapse structure or activity 2/436 218/18722 0.964313873907706 0.990040389550619 TUBB/HSPA8 2 GO:0035296 regulation of tube diameter 1/436 141/18722 0.964388844707009 0.990040389550619 GPX1 1 GO:0097746 blood vessel diameter maintenance 1/436 141/18722 0.964388844707009 0.990040389550619 GPX1 1 GO:0050953 sensory perception of light stimulus 2/436 219/18722 0.96501879117207 0.990040389550619 TACSTD2/EFEMP1 2 GO:0035150 regulation of tube size 1/436 142/18722 0.965224454400123 0.990040389550619 GPX1 1 GO:0072006 nephron development 1/436 142/18722 0.965224454400123 0.990040389550619 TACSTD2 1 GO:0048705 skeletal system morphogenesis 2/436 220/18722 0.965710331859721 0.990174537874533 TMEM107/SLC39A1 2 GO:0070555 response to interleukin-1 1/436 143/18722 0.966040500572434 0.990174537874533 RBMX 1 GO:0051480 regulation of cytosolic calcium ion concentration 4/436 353/18722 0.966221029671797 0.990174537874533 HMGB1/CALM2/BAX/GSTO1 4 GO:0010324 membrane invagination 1/436 144/18722 0.966837440222061 0.990214703702057 AURKB 1 GO:0014065 phosphatidylinositol 3-kinase signaling 1/436 144/18722 0.966837440222061 0.990214703702057 C1QBP 1 GO:0007269 neurotransmitter secretion 1/436 145/18722 0.967615719695804 0.990218590703956 PNKD 1 GO:0099643 signal release from synapse 1/436 145/18722 0.967615719695804 0.990218590703956 PNKD 1 GO:0002274 myeloid leukocyte activation 2/436 223/18722 0.967707063430593 0.990218590703956 HMGB1/HSPD1 2 GO:0010001 glial cell differentiation 2/436 225/18722 0.968975611778281 0.991221026836996 CDK1/GSTP1 2 GO:0046879 hormone secretion 3/436 295/18722 0.969617885052481 0.991582403462015 HADH/UQCC2/MPC2 3 GO:0032368 regulation of lipid transport 1/436 149/18722 0.970550803682674 0.991945131794833 DBI 1 GO:0045834 positive regulation of lipid metabolic process 1/436 149/18722 0.970550803682674 0.991945131794833 CD81 1 GO:0001959 regulation of cytokine-mediated signaling pathway 1/436 150/18722 0.971242121703153 0.992159498935125 GSTP1 1 GO:0045444 fat cell differentiation 2/436 229/18722 0.971370412546711 0.992159498935125 CCND1/GPX1 2 GO:0072503 cellular divalent inorganic cation homeostasis 6/436 486/18722 0.971890411237911 0.992159498935125 HMGB1/MT2A/CALM2/BAX/SLC39A10/GSTO1 6 GO:0043535 regulation of blood vessel endothelial cell migration 1/436 151/18722 0.971917247426684 0.992159498935125 HMGB1 1 GO:0042886 amide transport 3/436 301/18722 0.972734457615897 0.992507268761159 HADH/UQCC2/MPC2 3 GO:0010594 regulation of endothelial cell migration 2/436 232/18722 0.97304863187418 0.992507268761159 HMGB1/EMP2 2 GO:0007160 cell-matrix adhesion 2/436 233/18722 0.973586661112705 0.992507268761159 EMP2/CDKN2A 2 GO:0044782 cilium organization 4/436 368/18722 0.973655418471148 0.992507268761159 CENPJ/TMEM107/HSPB11/VDAC3 4 GO:0015849 organic acid transport 3/436 303/18722 0.973704303891012 0.992507268761159 SLC27A2/SLC25A1/MPC2 3 GO:0048588 developmental cell growth 2/436 234/18722 0.974114325621301 0.992630309238694 PARP2/HSP90AA1 2 GO:0009914 hormone transport 3/436 306/18722 0.97509802023595 0.993337680353191 HADH/UQCC2/MPC2 3 GO:0007034 vacuolar transport 1/436 157/18722 0.975648548227001 0.993603493311618 HSPA8 1 GO:0050804 modulation of chemical synaptic transmission 5/436 439/18722 0.977055557513177 0.994741132886561 YWHAH/NSG1/ZDHHC12/PNKD/HRAS 5 GO:0099177 regulation of trans-synaptic signaling 5/436 440/18722 0.977415333797122 0.994812224935606 YWHAH/NSG1/ZDHHC12/PNKD/HRAS 5 GO:0003205 cardiac chamber development 1/436 161/18722 0.977856969234465 0.994966566264368 LY6E 1 GO:0060759 regulation of response to cytokine stimulus 1/436 162/18722 0.97837711154435 0.99520067290503 GSTP1 1 GO:0016055 Wnt signaling pathway 5/436 444/18722 0.978802537819509 0.995239379396159 ASPM/CCNE1/CCND1/WLS/BRD7 5 GO:0198738 cell-cell signaling by wnt 5/436 446/18722 0.979465948809549 0.995239379396159 ASPM/CCNE1/CCND1/WLS/BRD7 5 GO:0006959 humoral immune response 3/436 317/18722 0.979631986341381 0.995239379396159 HMGN2/CD81/C1QBP 3 GO:0071772 response to BMP 1/436 165/18722 0.979865527135011 0.995239379396159 SPINT2 1 GO:0071773 cellular response to BMP stimulus 1/436 165/18722 0.979865527135011 0.995239379396159 SPINT2 1 GO:0009451 RNA modification 1/436 167/18722 0.980800563339227 0.995599625093754 TPRKB 1 GO:0055088 lipid homeostasis 1/436 167/18722 0.980800563339227 0.995599625093754 TMEM97 1 GO:0008544 epidermis development 3/436 324/18722 0.982095731826973 0.996469748097203 EZH2/TFDP1/YBX1 3 GO:0060828 regulation of canonical Wnt signaling pathway 2/436 253/18722 0.982404518889904 0.996469748097203 ASPM/WLS 2 GO:0007219 Notch signaling pathway 1/436 172/18722 0.982952951980445 0.996469748097203 PERP 1 GO:1990138 neuron projection extension 1/436 172/18722 0.982952951980445 0.996469748097203 HSP90AA1 1 GO:0043547 positive regulation of GTPase activity 2/436 255/18722 0.983109908863023 0.996469748097203 EZH2/HRAS 2 GO:1903522 regulation of blood circulation 2/436 256/18722 0.983452241828114 0.996522339548807 CALM2/GSTO1 2 GO:0048771 tissue remodeling 1/436 175/18722 0.984127006363109 0.996864395195445 BAX 1 GO:0023061 signal release 5/436 463/18722 0.984370903795444 0.996864395195445 HADH/PNKD/UQCC2/MPC2/WLS 5 GO:0048015 phosphatidylinositol-mediated signaling 1/436 178/18722 0.985220374600207 0.997001120055931 C1QBP 1 GO:0007416 synapse assembly 1/436 179/18722 0.985567867949771 0.997001120055931 ZDHHC12 1 GO:0003018 vascular process in circulatory system 2/436 263/18722 0.985666957425523 0.997001120055931 SLC29A1/GPX1 2 GO:0060271 cilium assembly 3/436 337/18722 0.98593648391191 0.997001120055931 CENPJ/TMEM107/VDAC3 3 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 2/436 264/18722 0.985958845919491 0.997001120055931 CD81/SUZ12 2 GO:0048017 inositol lipid-mediated signaling 1/436 182/18722 0.986562195708721 0.997142896792853 C1QBP 1 GO:0001503 ossification 4/436 408/18722 0.986680307377364 0.997142896792853 FBXO5/ID3/RBMX/RRBP1 4 GO:0002040 sprouting angiogenesis 1/436 185/18722 0.987488163730346 0.997371766193352 HMGB1 1 GO:0007369 gastrulation 1/436 185/18722 0.987488163730346 0.997371766193352 WLS 1 GO:0046942 carboxylic acid transport 2/436 273/18722 0.988338568459204 0.997936912414222 SLC25A1/MPC2 2 GO:0034329 cell junction assembly 4/436 420/18722 0.989198653039137 0.998387572905437 CNTNAP2/ZDHHC12/MARVELD3/CLDN7 4 GO:0006816 calcium ion transport 4/436 422/18722 0.989571585537813 0.998387572905437 CALM2/BAX/VDAC1/GSTO1 4 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 1/436 193/18722 0.989657865185483 0.998387572905437 CD81 1 GO:0050808 synapse organization 4/436 426/18722 0.990280960093713 0.998600439841086 TUBB/ZDHHC12/HSPA8/MYH10 4 GO:0048568 embryonic organ development 4/436 427/18722 0.990450975452992 0.998600439841086 ID3/SLC39A1/EFEMP1/SPINT2 4 GO:0048562 embryonic organ morphogenesis 2/436 285/18722 0.990909296647175 0.998736753792277 SLC39A1/EFEMP1 2 GO:0099003 vesicle-mediated transport in synapse 1/436 200/18722 0.991245959654551 0.998736753792277 NSG1 1 GO:0009913 epidermal cell differentiation 1/436 202/18722 0.991653252574523 0.998736753792277 EZH2 1 GO:0007389 pattern specification process 4/436 436/18722 0.991858521715504 0.998736753792277 PRKDC/TMEM107/HSPB11/WLS 4 GO:1901888 regulation of cell junction assembly 1/436 204/18722 0.992041637109903 0.998736753792277 CNTNAP2 1 GO:0016050 vesicle organization 2/436 300/18722 0.993355362526898 0.999205781974222 FBXO5/PLEKHJ1 2 GO:0006874 cellular calcium ion homeostasis 4/436 448/18722 0.993429355033225 0.999205781974222 HMGB1/CALM2/BAX/GSTO1 4 GO:0010876 lipid localization 4/436 448/18722 0.993429355033225 0.999205781974222 SLC27A2/DBI/SQLE/HILPDA 4 GO:0060070 canonical Wnt signaling pathway 2/436 303/18722 0.993760812917944 0.999205781974222 ASPM/WLS 2 GO:0032535 regulation of cellular component size 3/436 382/18722 0.994014190514412 0.999205781974222 CDK4/ARPC5L/RDX 3 GO:0071805 potassium ion transmembrane transport 1/436 219/18722 0.994433911502193 0.999205781974222 ATP1B3 1 GO:0055074 calcium ion homeostasis 4/436 460/18722 0.994707225340531 0.999205781974222 HMGB1/CALM2/BAX/GSTO1 4 GO:0019932 second-messenger-mediated signaling 2/436 312/18722 0.99483735098337 0.999205781974222 CALM2/GSTO1 2 GO:0060560 developmental growth involved in morphogenesis 1/436 234/18722 0.99610821323352 0.999987199373424 HSP90AA1 1 GO:0030111 regulation of Wnt signaling pathway 2/436 328/18722 0.996320047501293 0.999987199373424 ASPM/WLS 2 GO:0006813 potassium ion transport 1/436 241/18722 0.996707052048307 0.999987199373424 ATP1B3 1 GO:0007409 axonogenesis 3/436 418/18722 0.997031510785139 0.999987199373424 STMN1/HSP90AA1/C12orf57 3 GO:0003007 heart morphogenesis 1/436 246/18722 0.997077622709979 0.999987199373424 LY6E 1 GO:0045165 cell fate commitment 1/436 258/18722 0.997805974204286 0.999987199373424 PRKDC 1 GO:0015850 organic hydroxy compound transport 1/436 284/18722 0.998821790861794 0.999987199373424 LY6E 1 GO:0048193 Golgi vesicle transport 1/436 296/18722 0.999115967807553 0.999987199373424 LMAN1 1 GO:0006869 lipid transport 2/436 398/18722 0.999183193857485 0.999987199373424 SLC27A2/DBI 2 GO:0090287 regulation of cellular response to growth factor stimulus 1/436 304/18722 0.999270117663332 0.999987199373424 NREP 1 GO:0006909 phagocytosis 1/436 308/18722 0.999336819845303 0.999987199373424 HMGB1 1 GO:0009101 glycoprotein biosynthetic process 1/436 317/18722 0.999465497107853 0.999987199373424 ITM2C 1 GO:0042742 defense response to bacterium 1/436 350/18722 0.999757866844496 0.999987199373424 HMGB2 1 GO:0009100 glycoprotein metabolic process 1/436 387/18722 0.999900521344097 0.999987199373424 ITM2C 1 GO:0019221 cytokine-mediated signaling pathway 1/436 472/18722 0.999987199373424 0.999987199373424 GSTP1 1