ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	122/664	182/18367	1.73714039526873e-133	1.08744988743823e-130	RPLP0/RPS4Y1/RPL8/RPL23A/RPS10/RPL10A/RPS5/RPL7A/RPL14/RPL27A/RPS12/RPS26/RPSA/RPL24/RPS16/RPS13/RPL15/RPL31/RPL6/RPL3/RPS3/RPS23/RPS3A/RPS14/RPS2/RPL35/RPS19/RPL18A/RPS25/RPL22/RPL26/RPL5/RPL29/RPL18/RPL19/RPS8/RPL32/RPS7/RPL13A/RPS27A/RPL23/RPS18/RPLP1/RPL7/RPS6/RPL36A/RPL27/RPS20/RPS4X/RPS17/RPL13/RPL12/RPL36AL/RPL11/RPS11/RPS15/RPL21/RPS24/RPL37/RPS15A/RPL35A/RPL9/RPL34/RPLP2/UBA52/RPS29/RPL36/RPL41/RPL37A/RPL30/RPL10/RPS27/RPS28/RPL38/RPL28/RPS9/RPL4/RPL17/MRPL27/MRPS15/MRPL51/MRPL52/MRPS21/MRPL20/MRPS7/MRPL57/MRPL4/MRPL21/MRPS34/MRPL11/MRPL12/MRPL46/MRPL34/MRPS12/MRPL17/MRPL22/MRPL14/MRPL15/MRPL13/MRPS18C/MRPS33/MRPS6/MRPL54/MRPL36/MRPS2/MRPS35/MRPS25/RPL26L1/MRPS36/MRPL16/MRPL3/MRPL43/MRPS18A/MRPS14/MRPS23/MRPL33/MRPL2/MRPL55/MRPL9/NDUFA7/MRPL47/MRPS16	122
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	39/664	72/18367	2.20883685342122e-37	6.91365935120841e-35	UQCRH/UQCR10/NDUFA4/COX5B/COX4I1/COX7B/COX6B1/NDUFS5/NDUFB2/NDUFS6/COX5A/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/CYB5A/NDUFB3/NDUFA13/NDUFS8/COX8A/NDUFA2/UQCRFS1/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/CYC1/NDUFA5/NDUFA7	39
GO:0009055	electron transfer activity	48/664	126/18367	1.41830279084793e-36	2.95952515690268e-34	UQCRH/UQCR10/NDUFA4/COX5B/COX4I1/COX7B/COX6B1/NDUFS5/NDUFB2/NDUFS6/COX5A/NDUFB10/COX7A2/NDUFB7/NDUFB4/NDUFA6/AKR1B1/NDUFA1/ETFB/NDUFV2/NDUFA12/CYB5A/NDUFB3/ETFA/NDUFA13/NDUFS8/COX8A/NDUFA2/UQCRFS1/UQCR11/ADH5/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/CYCS/NDUFB9/NDUFS7/NDUFB1/NDUFB5/CYC1/SDHB/SDHC/NDUFA5/NDUFA7	48
GO:0008137	NADH dehydrogenase (ubiquinone) activity	28/664	42/18367	7.97806240081285e-31	1.24856676572721e-28	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	28
GO:0050136	NADH dehydrogenase (quinone) activity	28/664	43/18367	2.21045287171709e-30	2.7674869953898e-28	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	28
GO:0003954	NADH dehydrogenase activity	28/664	45/18367	1.50310861520039e-29	1.34420856159349e-27	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	28
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	28/664	45/18367	1.50310861520039e-29	1.34420856159349e-27	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	28
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	29/664	57/18367	4.88557779597841e-27	3.82296462535311e-25	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/DCXR/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	29
GO:0019843	rRNA binding	29/664	68/18367	3.07233724880814e-24	2.13698124194878e-22	RPLP0/RPS4Y1/NPM1/RPL8/RPL23A/RPS5/RPS13/RPS3/RPS14/RPL5/RPL19/RPL23/RPS18/RPS4X/RPL12/RPL11/RPS11/RPL37/RPL9/RPS9/MRPL20/MRPS7/MRPL11/MRPS18C/MRPS6/IMP3/MRPL16/MRPS18A/EMG1	29
GO:0016651	oxidoreductase activity, acting on NAD(P)H	29/664	88/18367	1.70992908044891e-20	1.07041560436102e-18	NDUFA4/NDUFS5/NDUFB2/NDUFS6/NDUFB10/NDUFB7/DCXR/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/NDUFB3/NDUFA13/NDUFS8/NDUFA2/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/NDUFA5/NDUFA7	29
GO:0015399	primary active transmembrane transporter activity	39/664	181/18367	1.04953944677708e-19	5.97283357893137e-18	UQCRH/UQCR10/NDUFA4/COX5B/COX4I1/COX7B/COX6B1/NDUFS5/NDUFB2/NDUFS6/COX5A/NDUFB10/NDUFB7/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/CYB5A/NDUFB3/NDUFA13/NDUFS8/COX8A/NDUFA2/UQCRFS1/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/CYC1/NDUFA5/NDUFA7	39
GO:0003743	translation initiation factor activity	17/664	51/18367	1.17910712325493e-12	6.15100882631324e-11	EIF2S2/EIF3F/EIF3G/EIF3H/EIF3K/EIF3I/EIF3L/EIF3M/EIF1AY/EIF3E/EIF6/MTIF3/EIF3J/MCTS1/EIF3D/EIF4E2/COPS5	17
GO:0051082	unfolded protein binding	25/664	122/18367	1.40385859449157e-12	6.3808436204602e-11	HSPE1/NPM1/NACA/PPIA/HSP90AB1/HSPD1/PTGES3/CCT3/NUDC/PFDN4/CCT8/PFDN2/CCT7/ST13/PFDN6/TUBB4B/TTC1/CCT2/CCT5/CCT4/PFDN1/NUDCD2/CCT6A/MKKS/GRPEL1	25
GO:0008135	translation factor activity, RNA binding	21/664	84/18367	1.48388466339711e-12	6.3808436204602e-11	EEF1A1/EEF1B2/EIF2S2/EIF3F/EIF3G/EIF3H/EIF3K/EIF5A/EIF3I/EEF1D/EIF3L/EIF3M/EIF1AY/EIF3E/EIF6/MTIF3/EIF3J/MCTS1/EIF3D/EIF4E2/COPS5	21
GO:0045296	cadherin binding	42/664	332/18367	1.52895613908791e-12	6.3808436204602e-11	PRDX1/RPL23A/RPL7A/PSMB6/RPL14/KRT18/PARK7/RPS26/RPL24/S100A11/RPL15/RPL6/RAN/ALDOA/RPS2/RPL29/PRDX6/ANXA2/HSP90AB1/RPL34/PFN1/S100P/ENO1/PDLIM1/LDHA/YWHAE/RANBP1/CTNNAL1/EEF1D/NUDC/CCT8/PKM/CNN3/EIF3E/AHSA1/ATIC/OLA1/RUVBL1/ZC3H15/LYPLA2/RSL1D1/PAICS	42
GO:0045182	translation regulator activity	25/664	140/18367	3.40988810772194e-11	1.33411872214621e-09	RPS14/RPL22/EEF1A1/RPL10/RPS9/EEF1B2/EIF2S2/EIF3F/EIF3G/EIF3H/EIF3K/EIF5A/EIF3I/EEF1D/EIF3L/EIF3M/EIF1AY/EIF3E/EIF6/MTIF3/EIF3J/MCTS1/EIF3D/EIF4E2/COPS5	25
GO:0090079	translation regulator activity, nucleic acid binding	21/664	108/18367	2.4695549506081e-10	9.09377293576865e-09	EEF1A1/EEF1B2/EIF2S2/EIF3F/EIF3G/EIF3H/EIF3K/EIF5A/EIF3I/EEF1D/EIF3L/EIF3M/EIF1AY/EIF3E/EIF6/MTIF3/EIF3J/MCTS1/EIF3D/EIF4E2/COPS5	21
GO:0022804	active transmembrane transporter activity	42/664	406/18367	9.62125500808501e-10	3.34605868614512e-08	UQCRH/UQCR10/SLC25A6/SLC25A3/NDUFA4/COX5B/COX4I1/COX7B/COX6B1/NDUFS5/NDUFB2/NDUFS6/COX5A/NDUFB10/NDUFB7/SLC25A5/NDUFB4/NDUFA6/NDUFA1/NDUFV2/NDUFA12/CYB5A/NDUFB3/NDUFA13/NDUFS8/COX8A/NDUFA2/UQCRFS1/NDUFB8/NDUFC2/NDUFB6/NDUFS4/NDUFC1/NDUFA10/NDUFA8/NDUFB9/NDUFS7/NDUFB1/NDUFB5/CYC1/NDUFA5/NDUFA7	42
GO:0004298	threonine-type endopeptidase activity	8/664	14/18367	6.93178389678958e-09	2.28384037862646e-07	PSMB6/PSMB1/PSMB7/PSMB5/PSMB3/PSMB2/PSMA4/PSMB4	8
GO:0044183	protein folding chaperone	12/664	40/18367	9.96197062794666e-09	3.11809680654731e-07	HSP90AB1/WDR83OS/CCT3/CCT8/PFDN2/CCT7/CCT2/CCT5/CCT4/PFDN1/CCT6A/PDCL3	12
GO:0048027	mRNA 5'-UTR binding	10/664	27/18367	1.72317108460055e-08	5.1366909474283e-07	RPS13/RPS3A/RPS14/RPL26/RPL5/RPS7/RPL41/NCL/CCT5/RSL1D1	10
GO:0043021	ribonucleoprotein complex binding	22/664	149/18367	2.02977522072157e-08	5.77563312805321e-07	NPM1/SNRPD2/RPSA/SNRPG/RPLP1/C1QBP/NME1/SNRPD1/SNRPC/SEC61B/EIF3K/EIF5A/SNRPB/RBM3/EIF6/CSNK2B/SNRPB2/NAA10/OLA1/MTIF3/MALSU1/STRAP	22
GO:0055106	ubiquitin-protein transferase regulator activity	8/664	22/18367	5.70673971760433e-07	1.55322567966101e-05	RPL5/RPS7/RPL23/RPS20/RPL11/RPS15/RPL37/UBE2L3	8
GO:0070003	threonine-type peptidase activity	8/664	24/18367	1.23093787615924e-06	3.2106962936487e-05	PSMB6/PSMB1/PSMB7/PSMB5/PSMB3/PSMB2/PSMA4/PSMB4	8
GO:0004129	cytochrome-c oxidase activity	7/664	19/18367	2.6952765398499e-06	6.74897245578414e-05	COX5B/COX4I1/COX7B/COX6B1/COX5A/CYB5A/COX8A	7
GO:0031386	protein tag	6/664	13/18367	3.01401490610684e-06	7.2568205047034e-05	RPS27A/UBA52/UBL5/NEDD8/UBB/SUMO1	6
GO:0016675	oxidoreductase activity, acting on a heme group of donors	7/664	20/18367	4.01749475289885e-06	9.31463598264697e-05	COX5B/COX4I1/COX7B/COX6B1/COX5A/CYB5A/COX8A	7
GO:0031625	ubiquitin protein ligase binding	27/664	297/18367	1.12438090787031e-05	0.000251379445831006	RPL5/PRDX6/RPS27A/RPL23/HSP90AB1/RPL11/UBA52/TPI1/PSMA3/ACTG1/NEDD8/SLC25A5/UBB/RBX1/HSPD1/YWHAE/UBE2L3/CACYBP/BAG2/CCT2/UBE2N/PA2G4/SUMO1/TSG101/OTUB1/EIF4E2/RRAGA	27
GO:0140678	molecular function inhibitor activity	16/664	128/18367	1.54124718821016e-05	0.000332696806834331	ANXA5/RPL5/RPS7/RPL23/ANXA2/RPS20/RPL11/RPS15/RPL37/DYNLL1/ANXA3/PHPT1/CAV1/COMMD1/ENSA/MDFI	16
GO:0070122	isopeptidase activity	6/664	18/18367	2.79217024756433e-05	0.000582632858325091	EIF3F/EIF3H/PSMD7/PSMD14/COPS6/COPS5	6
GO:0044389	ubiquitin-like protein ligase binding	27/664	316/18367	3.39420205597613e-05	0.000685409834529372	RPL5/PRDX6/RPS27A/RPL23/HSP90AB1/RPL11/UBA52/TPI1/PSMA3/ACTG1/NEDD8/SLC25A5/UBB/RBX1/HSPD1/YWHAE/UBE2L3/CACYBP/BAG2/CCT2/UBE2N/PA2G4/SUMO1/TSG101/OTUB1/EIF4E2/RRAGA	27
GO:0004857	enzyme inhibitor activity	11/664	70/18367	3.94006138564038e-05	0.0007707745085659	ANXA5/RPL5/RPS7/RPL23/ANXA2/RPS20/RPL11/RPS15/RPL37/DYNLL1/ANXA3	11
GO:0016209	antioxidant activity	12/664	86/18367	5.9652441545971e-05	0.00113158873962963	PRDX1/GSTP1/PRDX5/PARK7/SOD1/PRDX2/TXN/PRDX6/MGST3/GSTO1/TXNDC17/PRDX3	12
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	5/664	14/18367	9.27940512104565e-05	0.00165968788736417	ECH1/MIF/ECI1/ECI2/DDT	5
GO:0043023	ribosomal large subunit binding	5/664	14/18367	9.27940512104565e-05	0.00165968788736417	NPM1/RBM3/EIF6/OLA1/MALSU1	5
GO:0070034	telomerase RNA binding	6/664	22/18367	9.91656611807241e-05	0.00172438066386481	NHP2/SNRPD3/SNRPB/HNRNPC/NOP10/GAR1	6
GO:0017069	snRNA binding	9/664	53/18367	0.000106536262037225	0.00180247837933251	LSM7/LSM3/SNU13/SNRPD3/EIF5A/SNRPA1/LSM4/SNRPB2/LSM2	9
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	9/664	55/18367	0.000143335302897718	0.00236126051615715	PRDX1/GSTP1/PRDX5/PARK7/PRDX2/PRDX6/MGST3/TXNDC17/PRDX3	9
GO:0051536	iron-sulfur cluster binding	10/664	68/18367	0.000156010214396082	0.00244155985529868	RPS3/NDUFV2/NDUFS8/UQCRFS1/CISD1/NFU1/ISCU/NDUFS7/GLRX3/SDHB	10
GO:0051540	metal cluster binding	10/664	68/18367	0.000156010214396082	0.00244155985529868	RPS3/NDUFV2/NDUFS8/UQCRFS1/CISD1/NFU1/ISCU/NDUFS7/GLRX3/SDHB	10
GO:0017070	U6 snRNA binding	5/664	16/18367	0.000190626442004967	0.00291054030963681	LSM7/LSM3/EIF5A/LSM4/LSM2	5
GO:0098641	cadherin binding involved in cell-cell adhesion	5/664	18/18367	0.000352104979816046	0.00524804088963917	KRT18/S100A11/ANXA2/PDLIM1/CNN3	5
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	7/664	39/18367	0.000438485573217712	0.00638353415893692	POLR2L/POLR2F/POLR2I/POLR2J/POLR2E/POLR2G/POLR2H	7
GO:0004601	peroxidase activity	8/664	51/18367	0.000450400093797804	0.00640796497085057	PRDX1/GSTP1/PRDX5/PRDX2/PRDX6/MGST3/TXNDC17/PRDX3	8
GO:0051087	chaperone binding	12/664	107/18367	0.000485787484822025	0.00675784367774639	HSPE1/SOD1/HSPD1/TBCA/PTGES3/PFDN4/AHSA1/ST13/PFDN6/BAG2/TIMM9/GRPEL1	12
GO:0043022	ribosome binding	9/664	66/18367	0.000586338029884402	0.00797929579799208	RPSA/C1QBP/SEC61B/EIF3K/EIF5A/EIF6/NAA10/OLA1/MTIF3	9
GO:0034062	5'-3' RNA polymerase activity	7/664	43/18367	0.000810701677841711	0.010572901048519	POLR2L/POLR2F/POLR2I/POLR2J/POLR2E/POLR2G/POLR2H	7
GO:0097747	RNA polymerase activity	7/664	43/18367	0.000810701677841711	0.010572901048519	POLR2L/POLR2F/POLR2I/POLR2J/POLR2E/POLR2G/POLR2H	7
GO:0015078	proton transmembrane transporter activity	13/664	130/18367	0.000866605386074224	0.0110713259527033	UQCRH/UQCR10/SLC25A3/COX5B/COX4I1/COX7B/COX6B1/COX5A/SLC25A5/CYB5A/COX8A/UQCRFS1/CYC1	13
GO:0051537	2 iron, 2 sulfur cluster binding	5/664	24/18367	0.00145945905705795	0.0182724273943656	NDUFV2/UQCRFS1/CISD1/ISCU/SDHB	5
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	12/664	124/18367	0.00179246331196554	0.0218022287318664	LDHB/DCXR/AKR1B1/LDHA/MDH2/IMPDH2/ADH5/GRHPR/HSD17B10/MDH1/IDH2/HADHB	12
GO:0016853	isomerase activity	14/664	158/18367	0.00181104775408475	0.0218022287318664	ECH1/MIF/PPIA/TPI1/HSPD1/ISYNA1/FKBP3/PTGES3/ECI1/ECI2/PGAM1/DDT/PIN4/FKBP4	14
GO:0016835	carbon-oxygen lyase activity	9/664	79/18367	0.00215311940209083	0.0254311838812992	PARK7/ECHS1/RPS3/ENO1/TPI1/ECI1/PCBD1/XRCC6/HADHB	9
GO:0016860	intramolecular oxidoreductase activity	7/664	51/18367	0.0022704075237257	0.026319909441709	ECH1/MIF/TPI1/PTGES3/ECI1/ECI2/DDT	7
GO:0003713	transcription coactivator activity	19/664	262/18367	0.00324876063470071	0.0369768028604118	VGLL1/PAGE4/NPM1/PARK7/HMGA1/EDF1/PDLIM1/SUB1/UBE2L3/ENY2/PCBD1/APEX1/TSG101/RUVBL1/TAF9/BUD31/PMF1/COPS5/ABT1	19
GO:0015036	disulfide oxidoreductase activity	6/664	42/18367	0.00377614726446852	0.042211931920666	TXN/GSTO1/TXNDC17/TXNL1/TXN2/GLRX3	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	12/664	136/18367	0.00386609603028606	0.0424592300870013	LDHB/DCXR/AKR1B1/LDHA/MDH2/IMPDH2/ADH5/GRHPR/HSD17B10/MDH1/IDH2/HADHB	12
GO:0003746	translation elongation factor activity	4/664	19/18367	0.0042531199482309	0.0449121237363286	EEF1A1/EEF1B2/EIF5A/EEF1D	4
GO:0035615	clathrin adaptor activity	4/664	19/18367	0.0042531199482309	0.0449121237363286	AP2S1/AP1S1/AP1M2/AP2M1	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	7/664	57/18367	0.00430467639645322	0.0449121237363286	TXN/GSTO1/TXNDC17/PRDX3/TXNL1/TXN2/GLRX3	7
GO:0048306	calcium-dependent protein binding	9/664	88/18367	0.00449127924578153	0.0460908329157253	S100A10/S100A11/ANXA2/S100P/ANXA3/S100A13/PDCD6/PEF1/TSG101	9
GO:0004300	enoyl-CoA hydratase activity	3/664	10/18367	0.00466597295227514	0.0471112752923265	ECHS1/ECI1/HADHB	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	7/664	58/18367	0.00474640326528847	0.0471626737154061	GSTP1/SMS/GSTO1/SRM/FDPS/GSTA4/FDFT1	7
GO:0140312	cargo adaptor activity	4/664	20/18367	0.00516639102634309	0.0505337622264184	AP2S1/AP1S1/AP1M2/AP2M1	4
GO:0030515	snoRNA binding	5/664	32/18367	0.00545050033185993	0.0524925108883741	SNU13/NHP2/NOP10/IMP3/GAR1	5
GO:0031369	translation initiation factor binding	5/664	33/18367	0.00623640467215965	0.0569511667938037	RPS24/EIF2S2/EIF3F/EIF3M/POLR2G	5
GO:0000774	adenyl-nucleotide exchange factor activity	3/664	11/18367	0.00624474825135204	0.0569511667938037	PFN1/BAG2/GRPEL1	3
GO:0097371	MDM2/MDM4 family protein binding	3/664	11/18367	0.00624474825135204	0.0569511667938037	RPS20/RPS15/RPL37	3
GO:0005507	copper ion binding	7/664	61/18367	0.00627736502998795	0.0569511667938037	PARK7/SOD1/S100A13/COMMD1/CUTA/RNF7/COA6	7
GO:0003712	transcription coregulator activity	29/664	489/18367	0.00646363837019183	0.0578033945677155	VGLL1/PAGE4/NPM1/PARK7/HMGA1/EDF1/SAP18/C1QBP/PDLIM1/SUB1/HSBP1/UBE2L3/PHB/ENY2/PCBD1/APEX1/UXT/PA2G4/TSG101/EID2/RUVBL1/FHL2/TAF9/CCND1/BUD31/PMF1/HSBP1L1/COPS5/ABT1	29
GO:0046790	virion binding	3/664	12/18367	0.00810487705022389	0.0714599018794388	PPIA/ANXA2/TSG101	3
GO:0004859	phospholipase inhibitor activity	3/664	13/18367	0.0102566472905228	0.086765691944152	ANXA5/ANXA2/ANXA3	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/664	13/18367	0.0102566472905228	0.086765691944152	TXN/TXNDC17/PRDX3	3
GO:0060590	ATPase regulator activity	3/664	13/18367	0.0102566472905228	0.086765691944152	PFN1/BAG2/GRPEL1	3
GO:0097110	scaffold protein binding	7/664	67/18367	0.010401997356136	0.0868220045992149	KRT8/KRT18/PARK7/DYNLL1/YWHAE/XRCC6/MAP2K2	7
GO:0016829	lyase activity	14/664	196/18367	0.0120252523025839	0.0990501044923361	PARK7/ECHS1/RPS3/ALDOA/MGST3/ENO1/TPI1/ECI1/GGCT/PCBD1/DDT/XRCC6/HADHB/PAICS	14
GO:0044548	S100 protein binding	3/664	14/18367	0.0127080649710923	0.103314917816932	S100A11/ANXA2/CACYBP	3
GO:0097602	cullin family protein binding	4/664	26/18367	0.0134372458830093	0.107842511830305	SKP1/ANAPC11/RBX1/RNF7	4
GO:0051287	NAD binding	6/664	56/18367	0.0153026225220611	0.121258755681142	GAPDH/LDHA/GRHPR/PARP1/MDH1/IDH2	6
GO:0019205	nucleobase-containing compound kinase activity	5/664	42/18367	0.0171481991961266	0.13418465870969	NME1/MPP1/AK2/DGUOK/ADK	5
GO:0098631	cell adhesion mediator activity	6/664	59/18367	0.0194063528988742	0.149704255927771	KRT18/RPSA/S100A11/ANXA2/PDLIM1/CNN3	6
GO:0051059	NF-kappaB binding	4/664	29/18367	0.0196098226614652	0.149704255927771	NPM1/COMMD6/APEX1/COMMD7	4
GO:0008308	voltage-gated anion channel activity	3/664	17/18367	0.0219100016409216	0.161360717967258	VDAC1/VDAC2/VDAC3	3
GO:0043024	ribosomal small subunit binding	3/664	17/18367	0.0219100016409216	0.161360717967258	NPM1/NME1/MTIF3	3
GO:0070628	proteasome binding	3/664	17/18367	0.0219100016409216	0.161360717967258	PSMD14/ADRM1/PSMG1	3
GO:0044325	transmembrane transporter binding	10/664	133/18367	0.0226133318421475	0.164604020153307	S100A10/HSP90AB1/VDAC1/PHPT1/CAV1/YWHAE/SRI/BAG2/AP2M1/RANGRF	10
GO:0055102	lipase inhibitor activity	3/664	18/18367	0.0256009313869791	0.184209000554585	ANXA5/ANXA2/ANXA3	3
GO:0016836	hydro-lyase activity	6/664	64/18367	0.02780436037276	0.197790109015315	PARK7/ECHS1/ENO1/ECI1/PCBD1/HADHB	6
GO:0008200	ion channel inhibitor activity	4/664	33/18367	0.0301861619390525	0.212320644649965	PHPT1/CAV1/COMMD1/ENSA	4
GO:0098632	cell-cell adhesion mediator activity	5/664	49/18367	0.0313355291044476	0.217956013548713	KRT18/S100A11/ANXA2/PDLIM1/CNN3	5
GO:0016248	channel inhibitor activity	4/664	34/18367	0.0332645082532598	0.228830573258688	PHPT1/CAV1/COMMD1/ENSA	4
GO:0016247	channel regulator activity	10/664	145/18367	0.0378722127414399	0.257695708436319	VAMP8/PHPT1/CAV1/YWHAE/COMMD1/SRI/SUMO1/ENSA/SNF8/RANGRF	10
GO:0003714	transcription corepressor activity	12/664	187/18367	0.039419165742378	0.265337610265899	SAP18/C1QBP/HSBP1/PHB/APEX1/UXT/PA2G4/TSG101/EID2/FHL2/CCND1/HSBP1L1	12
GO:0042162	telomeric DNA binding	4/664	36/18367	0.0399508805534662	0.266055864111381	HNRNPA1/NCL/APEX1/XRCC6	4
GO:0051117	ATPase binding	7/664	89/18367	0.0421465126856542	0.274507656094142	SNU13/CAV1/RAC1/RUVBL1/TAF9/PIH1D1/NSFL1C	7
GO:0000062	fatty-acyl-CoA binding	3/664	22/18367	0.043456348928741	0.274507656094142	DBI/ACBD6/ECI2	3
GO:0004602	glutathione peroxidase activity	3/664	22/18367	0.043456348928741	0.274507656094142	GSTP1/PRDX6/MGST3	3
GO:0015035	protein-disulfide reductase activity	4/664	37/18367	0.0435597310362766	0.274507656094142	TXN/TXNDC17/TXN2/GLRX3	4
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4/664	37/18367	0.0435597310362766	0.274507656094142	GAPDH/AKR1B1/ALDH7A1/ADH5	4
GO:0031072	heat shock protein binding	9/664	129/18367	0.0445379440525872	0.274507656094142	RPS3/HSP90AB1/PTGES3/AHSA1/DNAJC8/ST13/BAG2/FKBP4/TOMM34	9
GO:0030276	clathrin binding	6/664	72/18367	0.0456728460994214	0.274507656094142	CLTA/AP2S1/AP1S1/AP1M2/AP2M1/NSG1	6
GO:0047485	protein N-terminus binding	8/664	110/18367	0.0460067881959533	0.274507656094142	NPM1/EIF5A/BANF1/MORF4L1/EIF3E/PARP1/SNF8/PHB2	8
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	4/664	38/18367	0.0473456017675699	0.274507656094142	PPIA/FKBP3/PIN4/FKBP4	4
GO:0140104	molecular carrier activity	6/664	73/18367	0.0483109925049461	0.274507656094142	PARK7/RAN/NDUFAB1/NUTF2/EMC6/TIMM9	6
GO:0001094	TFIID-class transcription factor complex binding	2/664	10/18367	0.0484447919328713	0.274507656094142	EDF1/RUVBL1	2
GO:0005528	FK506 binding	2/664	10/18367	0.0484447919328713	0.274507656094142	FKBP3/FKBP4	2
GO:0008097	5S rRNA binding	2/664	10/18367	0.0484447919328713	0.274507656094142	RPL5/RPL11	2
GO:0016783	sulfurtransferase activity	2/664	10/18367	0.0484447919328713	0.274507656094142	TSTD1/MOCS2	2
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	3/664	23/18367	0.0486746802339453	0.274507656094142	ADI1/ETHE1/CDO1	3
GO:0017134	fibroblast growth factor binding	3/664	23/18367	0.0486746802339453	0.274507656094142	RPS2/RPS19/S100A13	3
GO:1901567	fatty acid derivative binding	3/664	23/18367	0.0486746802339453	0.274507656094142	DBI/ACBD6/ECI2	3
GO:0016779	nucleotidyltransferase activity	9/664	132/18367	0.0502486758647578	0.280854206172664	POLR2L/UGP2/PTGES3/POLR2F/POLR2I/POLR2J/POLR2E/POLR2G/POLR2H	9
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4/664	39/18367	0.0513079672588622	0.281743750035507	NME1/MPP1/PMVK/AK2	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/664	39/18367	0.0513079672588622	0.281743750035507	UBE2L3/UBE2I/UFC1/UBE2N	4
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3/664	24/18367	0.0541840522014456	0.294949710244391	ADI1/ETHE1/CDO1	3
GO:0005347	ATP transmembrane transporter activity	2/664	11/18367	0.0578225794176533	0.30937551038847	SLC25A6/SLC25A5	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/664	11/18367	0.0578225794176533	0.30937551038847	TXN/TXNDC17	2
GO:0016859	cis-trans isomerase activity	4/664	41/18367	0.0597583488037513	0.31029782428535	PPIA/FKBP3/PIN4/FKBP4	4
GO:0048487	beta-tubulin binding	4/664	41/18367	0.0597583488037513	0.31029782428535	TBCA/PDCD5/UXT/CCT5	4
GO:0008327	methyl-CpG binding	3/664	25/18367	0.059977694470491	0.31029782428535	ERH/PRMT1/DNMT1	3
GO:0120227	acyl-CoA binding	3/664	25/18367	0.059977694470491	0.31029782428535	DBI/ACBD6/ECI2	3
GO:0051539	4 iron, 4 sulfur cluster binding	4/664	42/18367	0.064243627709817	0.329643532347094	NDUFS8/NFU1/NDUFS7/SDHB	4
GO:0099106	ion channel regulator activity	9/664	139/18367	0.0653853719663889	0.332774332121621	VAMP8/PHPT1/CAV1/YWHAE/COMMD1/SRI/SUMO1/ENSA/RANGRF	9
GO:0004364	glutathione transferase activity	3/664	26/18367	0.0660481877645103	0.333436818875673	GSTP1/GSTO1/GSTA4	3
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/664	12/18367	0.0677661198911392	0.336679294062326	RPS3/APEX1	2
GO:0005527	macrolide binding	2/664	12/18367	0.0677661198911392	0.336679294062326	FKBP3/FKBP4	2
GO:0016504	peptidase activator activity	4/664	43/18367	0.0688999581799992	0.336963857974059	CAV1/BAD/PSMD14/ADRM1	4
GO:0016790	thiolester hydrolase activity	4/664	43/18367	0.0688999581799992	0.336963857974059	LYPLA2/ACOT13/PNKD/ESD	4
GO:0023026	MHC class II protein complex binding	3/664	27/18367	0.0723875466630501	0.351276001636197	HSP90AB1/YWHAE/PKM	3
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	4/664	44/18367	0.0737252216613455	0.355015298153864	GAPDH/AKR1B1/ALDH7A1/ADH5	4
GO:0003697	single-stranded DNA binding	8/664	123/18367	0.0778171747654287	0.363573878482814	HNRNPA1/SSBP1/SUB1/NME1/HSPD1/YBX1/POLR2G/POLR2H	8
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/664	13/18367	0.0782223876367059	0.363573878482814	DUSP9/DUSP14	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/664	13/18367	0.0782223876367059	0.363573878482814	ANAPC11/RBX1	2
GO:0061133	endopeptidase activator activity	2/664	13/18367	0.0782223876367059	0.363573878482814	PSMD14/ADRM1	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	3/664	28/18367	0.0789872962838061	0.363573878482814	SNX3/COMMD1/PHLDA3	3
GO:1990756	ubiquitin ligase-substrate adaptor activity	3/664	28/18367	0.0789872962838061	0.363573878482814	SKP1/PDCD6/PEF1	3
GO:0140296	general transcription initiation factor binding	4/664	46/18367	0.0838727320070572	0.38324328639721	EDF1/GTF2A2/PSMC5/RUVBL1	4
GO:0046625	sphingolipid binding	3/664	29/18367	0.0858385432402302	0.389383536727421	VDAC1/VDAC2/PHB2	3
GO:0032977	membrane insertase activity	2/664	14/18367	0.0891414414143082	0.401457139031345	EMC6/TIMM9	2
GO:0022829	wide pore channel activity	3/664	30/18367	0.0929320412205673	0.415538984314823	VDAC1/VDAC2/VDAC3	3
GO:0031210	phosphatidylcholine binding	3/664	31/18367	0.100258251515547	0.43080921799869	VDAC1/CHMP2A/VDAC2	3
GO:0140318	protein transporter activity	3/664	31/18367	0.100258251515547	0.43080921799869	TIMM8B/SEC61G/TOMM22	3
GO:0016763	pentosyltransferase activity	4/664	49/18367	0.100293269859149	0.43080921799869	APRT/PNP/QPRT/PARP1	4
GO:0001846	opsonin binding	2/664	15/18367	0.100476271290429	0.43080921799869	C1QBP/PHB	2
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/664	15/18367	0.100476271290429	0.43080921799869	ALDH7A1/ADH5	2
GO:1990825	sequence-specific mRNA binding	2/664	15/18367	0.100476271290429	0.43080921799869	SSB/SRSF3	2
GO:0022853	active ion transmembrane transporter activity	14/664	267/18367	0.105917464933345	0.451049884682134	UQCRH/UQCR10/SLC25A6/SLC25A3/COX5B/COX4I1/COX7B/COX6B1/COX5A/SLC25A5/CYB5A/COX8A/UQCRFS1/CYC1	14
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/664	16/18367	0.112182652485273	0.474502300376897	ALDH7A1/ADH5	2
GO:0043130	ubiquitin binding	6/664	92/18367	0.115958915484917	0.487183094587639	UCHL3/UBE2N/TSG101/ADRM1/OTUB1/NSFL1C	6
GO:0045505	dynein intermediate chain binding	3/664	34/18367	0.123534523868577	0.504942192941055	DYNLL1/DYNLRB1/DYNLT1	3
GO:0004659	prenyltransferase activity	2/664	17/18367	0.124219005931186	0.504942192941055	FDPS/FDFT1	2
GO:0030275	LRR domain binding	2/664	17/18367	0.124219005931186	0.504942192941055	POLR2J/PMF1	2
GO:0031489	myosin V binding	2/664	17/18367	0.124219005931186	0.504942192941055	RAB25/RAB11A	2
GO:0070064	proline-rich region binding	2/664	17/18367	0.124219005931186	0.504942192941055	PFN1/CCND1	2
GO:0008408	3'-5' exonuclease activity	4/664	54/18367	0.130629234692293	0.524191672547277	REXO2/APEX1/EXOSC7/ERI3	4
GO:0015459	potassium channel regulator activity	4/664	54/18367	0.130629234692293	0.524191672547277	CAV1/YWHAE/SUMO1/ENSA	4
GO:0000175	3'-5'-exoribonuclease activity	3/664	35/18367	0.131692209373987	0.524404675128876	REXO2/EXOSC7/ERI3	3
GO:0000295	adenine nucleotide transmembrane transporter activity	2/664	18/18367	0.136546265249212	0.524404675128876	SLC25A6/SLC25A5	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/664	18/18367	0.136546265249212	0.524404675128876	SLC25A6/SLC25A5	2
GO:0033549	MAP kinase phosphatase activity	2/664	18/18367	0.136546265249212	0.524404675128876	DUSP9/DUSP14	2
GO:0048038	quinone binding	2/664	18/18367	0.136546265249212	0.524404675128876	NDUFS7/SDHB	2
GO:0140597	protein carrier activity	2/664	18/18367	0.136546265249212	0.524404675128876	EMC6/TIMM9	2
GO:1904047	S-adenosyl-L-methionine binding	2/664	18/18367	0.136546265249212	0.524404675128876	PRMT1/METTL5	2
GO:0023023	MHC protein complex binding	3/664	36/18367	0.140032330175852	0.531274173879294	HSP90AB1/YWHAE/PKM	3
GO:0097718	disordered domain specific binding	3/664	36/18367	0.140032330175852	0.531274173879294	GAPDH/HSP90AB1/AP2M1	3
GO:0005525	GTP binding	18/664	377/18367	0.141050749607673	0.531914272616889	RAN/HSP90AB1/EEF1A1/GNAS/NME1/RHOC/RAC1/RAB25/TUBA1C/ARF4/RAB17/ARL2/TUBB4B/RAB11A/OLA1/RAB13/RRAGA/HRAS	18
GO:0030374	nuclear receptor coactivator activity	4/664	56/18367	0.143710494304273	0.538699218170507	HMGA1/ENY2/TSG101/BUD31	4
GO:0008022	protein C-terminus binding	10/664	189/18367	0.14797490052326	0.549141008319164	PHB/PRDX3/BANF1/NCL/DYNLT1/XRCC6/SNF8/PHB2/TAX1BP3/HRAS	10
GO:0000339	RNA cap binding	2/664	19/18367	0.149127749863032	0.549141008319164	EIF3D/EIF4E2	2
GO:0010314	phosphatidylinositol-5-phosphate binding	2/664	19/18367	0.149127749863032	0.549141008319164	SNX3/PHLDA3	2
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	3/664	38/18367	0.157218819755311	0.575549597466813	REXO2/EXOSC7/ERI3	3
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/664	20/18367	0.161929043981435	0.575952167797603	EDF1/RUVBL1	2
GO:0031681	G-protein beta-subunit binding	2/664	20/18367	0.161929043981435	0.575952167797603	GNG5/CCT5	2
GO:0031690	adrenergic receptor binding	2/664	20/18367	0.161929043981435	0.575952167797603	GNAS/C1QBP	2
GO:0050145	nucleoside monophosphate kinase activity	2/664	20/18367	0.161929043981435	0.575952167797603	MPP1/AK2	2
GO:0097001	ceramide binding	2/664	20/18367	0.161929043981435	0.575952167797603	VDAC1/VDAC2	2
GO:0003924	GTPase activity	16/664	337/18367	0.163186511560286	0.577145515461804	RAN/EEF1A1/GNAS/RHOC/RAC1/GNG5/RAB25/TUBA1C/ARF4/RAB17/ARL2/TUBB4B/RAB11A/RAB13/RRAGA/HRAS	16
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	4/664	59/18367	0.164238104085138	0.577466651696609	REXO2/APEX1/EXOSC7/ERI3	4
GO:0005504	fatty acid binding	3/664	39/18367	0.166044724130015	0.577466651696609	GSTP1/NDUFAB1/ADH5	3
GO:0050997	quaternary ammonium group binding	3/664	39/18367	0.166044724130015	0.577466651696609	VDAC1/CHMP2A/VDAC2	3
GO:0051020	GTPase binding	14/664	291/18367	0.170789641620591	0.582753363015307	SOD1/CLTA/ANXA2/PFN1/ENO1/CAV1/RANBP1/RAC1/YBX1/STOML2/BNIP3/NUTF2/LSM2/RANGRF	14
GO:0001848	complement binding	2/664	21/18367	0.174917881191818	0.582753363015307	C1QBP/PHB	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/664	21/18367	0.174917881191818	0.582753363015307	SLC25A6/SLC25A5	2
GO:0051428	peptide hormone receptor binding	2/664	21/18367	0.174917881191818	0.582753363015307	GNAS/PSMC5	2
GO:1990381	ubiquitin-specific protease binding	2/664	21/18367	0.174917881191818	0.582753363015307	PARK7/SUMO1	2
GO:0003925	G protein activity	3/664	40/18367	0.175012192087664	0.582753363015307	RAC1/RAB11A/HRAS	3
GO:0004532	exoribonuclease activity	3/664	40/18367	0.175012192087664	0.582753363015307	REXO2/EXOSC7/ERI3	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/664	40/18367	0.175012192087664	0.582753363015307	PRDX5/PRDX3/BAD	3
GO:0042826	histone deacetylase binding	7/664	127/18367	0.176691365374	0.585231718117057	HSP90AB1/YWHAE/PHB/RAC1/BEX4/PARP1/CCND1	7
GO:0140297	DNA-binding transcription factor binding	18/664	394/18367	0.18450715626323	0.603733772029471	NPM1/PARK7/RPS3/CHCHD2/HMGA1/GTF2A2/HMGN3/COMMD6/PSMC5/SRI/PARP1/APEX1/PHB2/FHL2/COMMD7/TAF9/BUD31/MKKS	18
GO:0008320	protein transmembrane transporter activity	2/664	22/18367	0.188064034418126	0.603733772029471	SEC61G/TOMM22	2
GO:0008649	rRNA methyltransferase activity	2/664	22/18367	0.188064034418126	0.603733772029471	METTL5/EMG1	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/664	22/18367	0.188064034418126	0.603733772029471	PRDX5/PRDX3	2
GO:0070182	DNA polymerase binding	2/664	22/18367	0.188064034418126	0.603733772029471	HSP90AB1/PTGES3	2
GO:0140102	catalytic activity, acting on a rRNA	2/664	22/18367	0.188064034418126	0.603733772029471	METTL5/EMG1	2
GO:0008307	structural constituent of muscle	3/664	42/18367	0.193331760638843	0.617477970203653	KRT19/CSRP2/MYL6	3
GO:0019001	guanyl nucleotide binding	18/664	398/18367	0.195620993360065	0.618478494158591	RAN/HSP90AB1/EEF1A1/GNAS/NME1/RHOC/RAC1/RAB25/TUBA1C/ARF4/RAB17/ARL2/TUBB4B/RAB11A/OLA1/RAB13/RRAGA/HRAS	18
GO:0032561	guanyl ribonucleotide binding	18/664	398/18367	0.195620993360065	0.618478494158591	RAN/HSP90AB1/EEF1A1/GNAS/NME1/RHOC/RAC1/RAB25/TUBA1C/ARF4/RAB17/ARL2/TUBB4B/RAB11A/OLA1/RAB13/RRAGA/HRAS	18
GO:0017025	TBP-class protein binding	2/664	23/18367	0.201339211007096	0.631182862116213	GTF2A2/RUVBL1	2
GO:0005246	calcium channel regulator activity	3/664	43/18367	0.202664145823257	0.631182862116213	PHPT1/YWHAE/SRI	3
GO:0030544	Hsp70 protein binding	3/664	43/18367	0.202664145823257	0.631182862116213	RPS3/DNAJC8/ST13	3
GO:0019887	protein kinase regulator activity	10/664	204/18367	0.205049198423644	0.635449496104956	NPM1/RPLP1/HSP90AB1/CDKN1C/PKIB/CD24/CCNE1/CSNK2B/MAP2K2/CCND1	10
GO:0003727	single-stranded RNA binding	5/664	87/18367	0.206512006526402	0.636830128500136	HNRNPA1/SNRPC/SSB/HNRNPC/POLR2G	5
GO:0061134	peptidase regulator activity	11/664	230/18367	0.21203982337948	0.646215444233915	GAPDH/PRDX5/PEBP1/ANXA2/CAV1/PRDX3/BAD/SERPINB1/PSMD14/ADRM1/SERPINB6	11
GO:0051879	Hsp90 protein binding	3/664	44/18367	0.212098701249738	0.646215444233915	RPS3/PTGES3/AHSA1	3
GO:0032182	ubiquitin-like protein binding	6/664	111/18367	0.213495392067422	0.646215444233915	UCHL3/UBE2N/TSG101/ADRM1/OTUB1/NSFL1C	6
GO:0008171	O-methyltransferase activity	2/664	24/18367	0.2147169527167	0.646215444233915	COMT/LCMT1	2
GO:0120014	phospholipid transfer activity	2/664	24/18367	0.2147169527167	0.646215444233915	PRELID1/TRIAP1	2
GO:0002020	protease binding	7/664	135/18367	0.216964557624671	0.649855564942793	PARK7/ANXA2/SRI/NDUFS7/SUMO1/ADRM1/SERPINB6	7
GO:0048156	tau protein binding	3/664	45/18367	0.221625963615111	0.66065644391933	HSP90AB1/BAG2/FKBP4	3
GO:0019207	kinase regulator activity	11/664	233/18367	0.223904458423754	0.664285265276162	GSTP1/NPM1/RPLP1/HSP90AB1/CDKN1C/PKIB/CD24/CCNE1/CSNK2B/MAP2K2/CCND1	11
GO:0008266	poly(U) RNA binding	2/664	25/18367	0.228172540390284	0.673754765492064	SSB/HNRNPC	2
GO:0101005	deubiquitinase activity	6/664	114/18367	0.230996795325138	0.676421240768472	EIF3F/EIF3H/UCHL3/PSMD14/OTUB1/COPS5	6
GO:0004864	protein phosphatase inhibitor activity	3/664	46/18367	0.231236654192417	0.676421240768472	LGALS3/PPP1R14B/ENSA	3
GO:0008198	ferrous iron binding	2/664	26/18367	0.241682903109098	0.703690685331607	ISCU/CDO1	2
GO:0001671	ATPase activator activity	2/664	27/18367	0.255226531624782	0.732898205491346	AHSA1/DNAJC19	2
GO:0015215	nucleotide transmembrane transporter activity	2/664	27/18367	0.255226531624782	0.732898205491346	SLC25A6/SLC25A5	2
GO:0022884	macromolecule transmembrane transporter activity	2/664	27/18367	0.255226531624782	0.732898205491346	SEC61G/TOMM22	2
GO:0019212	phosphatase inhibitor activity	3/664	49/18367	0.260479520763116	0.744439231281535	LGALS3/PPP1R14B/ENSA	3
GO:0060090	molecular adaptor activity	16/664	369/18367	0.262729203579129	0.744439231281535	VAMP8/SKP1/CAV1/LAMTOR5/AP2S1/PDCD6/AP1S1/ISCU/AP1M2/ST13/PEF1/AP2M1/LAMTOR2/MAP2K2/FKBP4/PSMG1	16
GO:0000049	tRNA binding	4/664	72/18367	0.262813211043481	0.744439231281535	EEF1A1/RPL35A/SSB/HSD17B10	4
GO:0008187	poly-pyrimidine tract binding	2/664	28/18367	0.268783395881781	0.748804639344149	SSB/HNRNPC	2
GO:0043236	laminin binding	2/664	28/18367	0.268783395881781	0.748804639344149	RPSA/LGALS3	2
GO:0061135	endopeptidase regulator activity	9/664	194/18367	0.269532714305291	0.748804639344149	GAPDH/PRDX5/PEBP1/ANXA2/PRDX3/SERPINB1/PSMD14/ADRM1/SERPINB6	9
GO:0015485	cholesterol binding	3/664	50/18367	0.270335221232872	0.748804639344149	VDAC1/CAV1/VDAC2	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/664	50/18367	0.270335221232872	0.748804639344149	CDKN1C/CCNE1/CCND1	3
GO:0003725	double-stranded RNA binding	4/664	74/18367	0.278937555058384	0.750455202635574	HSP90AB1/HSPD1/TUBB4B/ILF2	4
GO:0033218	amide binding	17/664	400/18367	0.280931067655029	0.750455202635574	PPIA/CLTA/HSP90AB1/SRP14/VDAC1/DBI/FKBP3/VDAC2/ACBD6/ECI2/PFDN4/PFDN2/PFDN6/AP2M1/PHB2/PFDN1/FKBP4	17
GO:0015301	anion:anion antiporter activity	2/664	29/18367	0.282334866447821	0.750455202635574	SLC25A6/SLC25A5	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/664	29/18367	0.282334866447821	0.750455202635574	COMMD1/PHLDA3	2
GO:0019003	GDP binding	4/664	75/18367	0.287058353202492	0.750455202635574	RAN/RAB17/ARL2/HRAS	4
GO:0016830	carbon-carbon lyase activity	3/664	52/18367	0.290159180570883	0.750455202635574	ALDOA/DDT/PAICS	3
GO:0019783	ubiquitin-like protein-specific protease activity	6/664	125/18367	0.298454847526894	0.750455202635574	EIF3F/EIF3H/UCHL3/PSMD14/OTUB1/COPS5	6
GO:0046982	protein heterodimerization activity	14/664	328/18367	0.300190452104731	0.750455202635574	RAN/TRMT112/CAV1/YWHAE/PHB/GTF2A2/SRI/PEF1/KRT10/LSM5/PHB2/TAF9/LSM6/RRAGA	14
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/664	10/18367	0.308094935006995	0.750455202635574	APEX1	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/664	10/18367	0.308094935006995	0.750455202635574	ACP1	1
GO:0005522	profilin binding	1/664	10/18367	0.308094935006995	0.750455202635574	ACTG1	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/664	10/18367	0.308094935006995	0.750455202635574	DUSP9	1
GO:0015643	toxic substance binding	1/664	10/18367	0.308094935006995	0.750455202635574	ASS1	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/664	10/18367	0.308094935006995	0.750455202635574	PGAM1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/664	10/18367	0.308094935006995	0.750455202635574	ADH5	1
GO:0019869	chloride channel inhibitor activity	1/664	10/18367	0.308094935006995	0.750455202635574	VAMP8	1
GO:0030957	Tat protein binding	1/664	10/18367	0.308094935006995	0.750455202635574	NPM1	1
GO:0032356	oxidized DNA binding	1/664	10/18367	0.308094935006995	0.750455202635574	RPS3	1
GO:0033204	ribonuclease P RNA binding	1/664	10/18367	0.308094935006995	0.750455202635574	POP7	1
GO:0034511	U3 snoRNA binding	1/664	10/18367	0.308094935006995	0.750455202635574	SNU13	1
GO:0043139	5'-3' DNA helicase activity	1/664	10/18367	0.308094935006995	0.750455202635574	RUVBL1	1
GO:0050786	RAGE receptor binding	1/664	10/18367	0.308094935006995	0.750455202635574	S100A13	1
GO:0097027	ubiquitin-protein transferase activator activity	1/664	10/18367	0.308094935006995	0.750455202635574	UBE2L3	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/664	10/18367	0.308094935006995	0.750455202635574	CASP4	1
GO:0098505	G-rich strand telomeric DNA binding	1/664	10/18367	0.308094935006995	0.750455202635574	HNRNPA1	1
GO:0140142	nucleocytoplasmic carrier activity	2/664	31/18367	0.309353666448187	0.750455202635574	RAN/NUTF2	2
GO:0005544	calcium-dependent phospholipid binding	3/664	54/18367	0.31008130350213	0.750455202635574	ANXA5/ANXA2/ANXA3	3
GO:0005200	structural constituent of cytoskeleton	5/664	103/18367	0.316157594241731	0.750455202635574	KRT19/ACTG1/ARPC2/TUBA1C/TUBB4B	5
GO:0005080	protein kinase C binding	3/664	55/18367	0.320060620166514	0.750455202635574	C1QBP/HINT1/GLRX3	3
GO:0015605	organophosphate ester transmembrane transporter activity	2/664	32/18367	0.322790084291118	0.750455202635574	SLC25A6/SLC25A5	2
GO:0050699	WW domain binding	2/664	32/18367	0.322790084291118	0.750455202635574	TCEAL4/TCEAL8	2
GO:0004527	exonuclease activity	4/664	80/18367	0.328073322636398	0.750455202635574	REXO2/APEX1/EXOSC7/ERI3	4
GO:0050840	extracellular matrix binding	3/664	56/18367	0.330042702762491	0.750455202635574	RPSA/ANXA2/LGALS3	3
GO:0004596	peptide alpha-N-acetyltransferase activity	1/664	11/18367	0.333122170565929	0.750455202635574	NAA10	1
GO:0005049	nuclear export signal receptor activity	1/664	11/18367	0.333122170565929	0.750455202635574	RAN	1
GO:0005078	MAP-kinase scaffold activity	1/664	11/18367	0.333122170565929	0.750455202635574	MAP2K2	1
GO:0005536	glucose binding	1/664	11/18367	0.333122170565929	0.750455202635574	UGP2	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/664	11/18367	0.333122170565929	0.750455202635574	PKIB	1
GO:0016273	arginine N-methyltransferase activity	1/664	11/18367	0.333122170565929	0.750455202635574	PRMT1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/664	11/18367	0.333122170565929	0.750455202635574	PRMT1	1
GO:0016832	aldehyde-lyase activity	1/664	11/18367	0.333122170565929	0.750455202635574	ALDOA	1
GO:0019107	myristoyltransferase activity	1/664	11/18367	0.333122170565929	0.750455202635574	HADHB	1
GO:0019855	calcium channel inhibitor activity	1/664	11/18367	0.333122170565929	0.750455202635574	PHPT1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/664	11/18367	0.333122170565929	0.750455202635574	HSD17B10	1
GO:0031996	thioesterase binding	1/664	11/18367	0.333122170565929	0.750455202635574	RAC1	1
GO:0043522	leucine zipper domain binding	1/664	11/18367	0.333122170565929	0.750455202635574	PMF1	1
GO:0099186	structural constituent of postsynapse	1/664	11/18367	0.333122170565929	0.750455202635574	ACTG1	1
GO:1901612	cardiolipin binding	1/664	11/18367	0.333122170565929	0.750455202635574	STOML2	1
GO:1990226	histone methyltransferase binding	1/664	11/18367	0.333122170565929	0.750455202635574	HSP90AB1	1
GO:0001530	lipopolysaccharide binding	2/664	33/18367	0.336159152794366	0.750455202635574	HSPD1/PSMB4	2
GO:0051427	hormone receptor binding	2/664	33/18367	0.336159152794366	0.750455202635574	GNAS/PSMC5	2
GO:0140323	solute:anion antiporter activity	2/664	33/18367	0.336159152794366	0.750455202635574	SLC25A6/SLC25A5	2
GO:0004536	deoxyribonuclease activity	3/664	57/18367	0.340020807845918	0.750455202635574	RPS3/NME1/APEX1	3
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	4/664	82/18367	0.344592753263773	0.750455202635574	ANXA2/PFN1/COMMD1/PHLDA3	4
GO:1902936	phosphatidylinositol bisphosphate binding	5/664	107/18367	0.344842768008081	0.750455202635574	ANXA2/PFN1/SNX3/COMMD1/PHLDA3	5
GO:0016831	carboxy-lyase activity	2/664	34/18367	0.349448192102228	0.750455202635574	DDT/PAICS	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/664	34/18367	0.349448192102228	0.750455202635574	APEX1/POP7	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/664	34/18367	0.349448192102228	0.750455202635574	CDKN1C/PKIB	2
GO:0035198	miRNA binding	2/664	34/18367	0.349448192102228	0.750455202635574	HNRNPA1/YBX1	2
GO:0000340	RNA 7-methylguanosine cap binding	1/664	12/18367	0.357245447900002	0.750455202635574	EIF4E2	1
GO:0003964	RNA-directed DNA polymerase activity	1/664	12/18367	0.357245447900002	0.750455202635574	PTGES3	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/664	12/18367	0.357245447900002	0.750455202635574	AKR1B1	1
GO:0004526	ribonuclease P activity	1/664	12/18367	0.357245447900002	0.750455202635574	POP7	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/664	12/18367	0.357245447900002	0.750455202635574	CDKN1C	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/664	12/18367	0.357245447900002	0.750455202635574	APEX1	1
GO:0008429	phosphatidylethanolamine binding	1/664	12/18367	0.357245447900002	0.750455202635574	PEBP1	1
GO:0030955	potassium ion binding	1/664	12/18367	0.357245447900002	0.750455202635574	PKM	1
GO:0033130	acetylcholine receptor binding	1/664	12/18367	0.357245447900002	0.750455202635574	LY6E	1
GO:0042975	peroxisome proliferator activated receptor binding	1/664	12/18367	0.357245447900002	0.750455202635574	HMGA1	1
GO:0043047	single-stranded telomeric DNA binding	1/664	12/18367	0.357245447900002	0.750455202635574	HNRNPA1	1
GO:0043422	protein kinase B binding	1/664	12/18367	0.357245447900002	0.750455202635574	BAD	1
GO:0061578	Lys63-specific deubiquitinase activity	1/664	12/18367	0.357245447900002	0.750455202635574	PSMD14	1
GO:0001540	amyloid-beta binding	4/664	84/18367	0.361129092242465	0.756076293457468	PFDN4/PFDN2/PFDN6/PFDN1	4
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/664	60/18367	0.369867538317145	0.76343382487971	AKR1B1/SDHB/SDHC	3
GO:0032934	sterol binding	3/664	60/18367	0.369867538317145	0.76343382487971	VDAC1/CAV1/VDAC2	3
GO:0000217	DNA secondary structure binding	2/664	36/18367	0.37574041816602	0.76343382487971	HMGA1/HMGB3	2
GO:0042805	actinin binding	2/664	36/18367	0.37574041816602	0.76343382487971	CSRP2/PDLIM1	2
GO:0061631	ubiquitin conjugating enzyme activity	2/664	36/18367	0.37574041816602	0.76343382487971	UBE2L3/UBE2N	2
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/664	13/18367	0.38049736958861	0.76343382487971	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/664	13/18367	0.38049736958861	0.76343382487971	HSPD1	1
GO:0016840	carbon-nitrogen lyase activity	1/664	13/18367	0.38049736958861	0.76343382487971	GGCT	1
GO:0019104	DNA N-glycosylase activity	1/664	13/18367	0.38049736958861	0.76343382487971	APEX1	1
GO:0032036	myosin heavy chain binding	1/664	13/18367	0.38049736958861	0.76343382487971	MYL12B	1
GO:0042301	phosphate ion binding	1/664	13/18367	0.38049736958861	0.76343382487971	PNP	1
GO:0052650	NADP-retinol dehydrogenase activity	1/664	13/18367	0.38049736958861	0.76343382487971	AKR1B1	1
GO:0140299	small molecule sensor activity	1/664	13/18367	0.38049736958861	0.76343382487971	PARK7	1
GO:0030674	protein-macromolecule adaptor activity	12/664	296/18367	0.384072076427386	0.768144152854772	VAMP8/SKP1/CAV1/AP2S1/PDCD6/AP1S1/AP1M2/ST13/PEF1/AP2M1/MAP2K2/FKBP4	12
GO:0005253	anion channel activity	4/664	87/18367	0.385900051348988	0.769342140587473	CLIC3/VDAC1/VDAC2/VDAC3	4
GO:0004843	thiol-dependent deubiquitinase	5/664	113/18367	0.388110883179297	0.770065253472481	EIF3F/UCHL3/PSMD14/OTUB1/COPS5	5
GO:0042056	chemoattractant activity	2/664	37/18367	0.388723035299208	0.770065253472481	MIF/LGALS3	2
GO:0051219	phosphoprotein binding	4/664	88/18367	0.394133919614524	0.770162576514545	PFN1/YWHAE/PIH1D1/RRAGA	4
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	12/664	299/18367	0.397325641003579	0.770162576514545	NPM1/PARK7/HMGA1/GTF2A2/HMGN3/COMMD6/PARP1/APEX1/PHB2/COMMD7/BUD31/MKKS	12
GO:0004520	endodeoxyribonuclease activity	2/664	38/18367	0.401584380607202	0.770162576514545	RPS3/APEX1	2
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/664	38/18367	0.401584380607202	0.770162576514545	GTF2A2/TAF9	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/664	38/18367	0.401584380607202	0.770162576514545	PARK7/RPS3	2
GO:0005172	vascular endothelial growth factor receptor binding	1/664	14/18367	0.402909364063556	0.770162576514545	PDCL3	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/664	14/18367	0.402909364063556	0.770162576514545	LYPLA2	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/664	14/18367	0.402909364063556	0.770162576514545	HSD17B10	1
GO:0098599	palmitoyl hydrolase activity	1/664	14/18367	0.402909364063556	0.770162576514545	LYPLA2	1
GO:0102991	myristoyl-CoA hydrolase activity	1/664	14/18367	0.402909364063556	0.770162576514545	ACOT13	1
GO:0000287	magnesium ion binding	9/664	221/18367	0.405908744845598	0.770162576514545	COMT/RAN/S100P/ENO1/PPA1/NME1/PDCD6/PKM/IDH2	9
GO:0004540	ribonuclease activity	5/664	116/18367	0.409707043274915	0.770162576514545	REXO2/APEX1/POP7/EXOSC7/ERI3	5
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/664	39/18367	0.414316253930294	0.770162576514545	COMMD1/PHLDA3	2
GO:0016922	nuclear receptor binding	6/664	144/18367	0.420878519818661	0.770162576514545	PARK7/HMGA1/HMGN3/PARP1/PHB2/BUD31	6
GO:0004549	tRNA-specific ribonuclease activity	1/664	15/18367	0.424511727833065	0.770162576514545	POP7	1
GO:0010851	cyclase regulator activity	1/664	15/18367	0.424511727833065	0.770162576514545	GNAS	1
GO:0016846	carbon-sulfur lyase activity	1/664	15/18367	0.424511727833065	0.770162576514545	MGST3	1
GO:0019215	intermediate filament binding	1/664	15/18367	0.424511727833065	0.770162576514545	NME1	1
GO:0030280	structural constituent of skin epidermis	1/664	15/18367	0.424511727833065	0.770162576514545	KRT10	1
GO:0030548	acetylcholine receptor regulator activity	1/664	15/18367	0.424511727833065	0.770162576514545	LY6E	1
GO:0050998	nitric-oxide synthase binding	1/664	15/18367	0.424511727833065	0.770162576514545	CAV1	1
GO:0051371	muscle alpha-actinin binding	1/664	15/18367	0.424511727833065	0.770162576514545	PDLIM1	1
GO:0070742	C2H2 zinc finger domain binding	1/664	15/18367	0.424511727833065	0.770162576514545	TAF9	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/664	15/18367	0.424511727833065	0.770162576514545	CASP4	1
GO:0098847	sequence-specific single stranded DNA binding	1/664	15/18367	0.424511727833065	0.770162576514545	HNRNPA1	1
GO:0099602	neurotransmitter receptor regulator activity	1/664	15/18367	0.424511727833065	0.770162576514545	LY6E	1
GO:1901611	phosphatidylglycerol binding	1/664	15/18367	0.424511727833065	0.770162576514545	STOML2	1
GO:0140098	catalytic activity, acting on RNA	15/664	386/18367	0.424551496908696	0.770162576514545	POLR2L/PTRHD1/POLR2F/POLR2I/METTL5/REXO2/APEX1/POLR2J/POLR2E/POLR2G/POLR2H/POP7/EXOSC7/ERI3/EMG1	15
GO:0016741	transferase activity, transferring one-carbon groups	9/664	225/18367	0.426588213584604	0.770162576514545	GCSH/COMT/TRMT112/PRMT1/LCMT1/DNMT1/METTL5/ATIC/EMG1	9
GO:0017080	sodium channel regulator activity	2/664	40/18367	0.42691120455359	0.770162576514545	COMMD1/RANGRF	2
GO:0031492	nucleosomal DNA binding	2/664	40/18367	0.42691120455359	0.770162576514545	HMGN3/HNRNPC	2
GO:0002039	p53 binding	3/664	66/18367	0.428653839294512	0.771084205167714	HSPD1/TRIAP1/TAF9	3
GO:0030331	estrogen receptor binding	2/664	41/18367	0.439362487878628	0.780893207380055	PARP1/PHB2	2
GO:0003688	DNA replication origin binding	1/664	16/18367	0.445333666189584	0.780893207380055	HSPD1	1
GO:0005092	GDP-dissociation inhibitor activity	1/664	16/18367	0.445333666189584	0.780893207380055	RANBP1	1
GO:0005159	insulin-like growth factor receptor binding	1/664	16/18367	0.445333666189584	0.780893207380055	GNAS	1
GO:0016208	AMP binding	1/664	16/18367	0.445333666189584	0.780893207380055	APRT	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/664	16/18367	0.445333666189584	0.780893207380055	APEX1	1
GO:0050700	CARD domain binding	1/664	16/18367	0.445333666189584	0.780893207380055	CASP4	1
GO:0070402	NADPH binding	1/664	16/18367	0.445333666189584	0.780893207380055	GRHPR	1
GO:1990404	protein ADP-ribosylase activity	1/664	16/18367	0.445333666189584	0.780893207380055	PARP1	1
GO:0003684	damaged DNA binding	3/664	68/18367	0.447834196177753	0.78308437655663	RPS3/APEX1/XRCC6	3
GO:0001046	core promoter sequence-specific DNA binding	2/664	42/18367	0.451664024240617	0.787581279037957	NPM1/PIH1D1	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/664	43/18367	0.463810359773172	0.7916915383622	SNX3/PHLDA3	2
GO:0000400	four-way junction DNA binding	1/664	17/18367	0.465403332455734	0.7916915383622	HMGB3	1
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	1/664	17/18367	0.465403332455734	0.7916915383622	BAD	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/664	17/18367	0.465403332455734	0.7916915383622	ACOT13	1
GO:0017081	chloride channel regulator activity	1/664	17/18367	0.465403332455734	0.7916915383622	VAMP8	1
GO:0031420	alkali metal ion binding	1/664	17/18367	0.465403332455734	0.7916915383622	PKM	1
GO:0034185	apolipoprotein binding	1/664	17/18367	0.465403332455734	0.7916915383622	HSPD1	1
GO:0046965	retinoid X receptor binding	1/664	17/18367	0.465403332455734	0.7916915383622	HMGA1	1
GO:0050780	dopamine receptor binding	1/664	17/18367	0.465403332455734	0.7916915383622	GNAS	1
GO:0004860	protein kinase inhibitor activity	3/664	70/18367	0.466750407803277	0.791831315135099	NPM1/CDKN1C/PKIB	3
GO:0004867	serine-type endopeptidase inhibitor activity	4/664	98/18367	0.475026474109601	0.796462372713479	PEBP1/ANXA2/SERPINB1/SERPINB6	4
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/664	71/18367	0.476100335054809	0.796462372713479	HINT1/NIT2/HINT2	3
GO:0031491	nucleosome binding	3/664	71/18367	0.476100335054809	0.796462372713479	ZNHIT1/HMGN3/HNRNPC	3
GO:0048029	monosaccharide binding	3/664	71/18367	0.476100335054809	0.796462372713479	ALDOA/UGP2/TALDO1	3
GO:0004866	endopeptidase inhibitor activity	7/664	180/18367	0.476467688144442	0.796462372713479	GAPDH/PRDX5/PEBP1/ANXA2/PRDX3/SERPINB1/SERPINB6	7
GO:0008242	omega peptidase activity	5/664	126/18367	0.480594831641364	0.796462372713479	EIF3F/UCHL3/PSMD14/OTUB1/COPS5	5
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/664	18/18367	0.484747865820824	0.796462372713479	HSD17B10	1
GO:0004550	nucleoside diphosphate kinase activity	1/664	18/18367	0.484747865820824	0.796462372713479	NME1	1
GO:0004708	MAP kinase kinase activity	1/664	18/18367	0.484747865820824	0.796462372713479	MAP2K2	1
GO:0008301	DNA binding, bending	1/664	18/18367	0.484747865820824	0.796462372713479	HMGB3	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/664	18/18367	0.484747865820824	0.796462372713479	AKR1B1	1
GO:0098918	structural constituent of synapse	1/664	18/18367	0.484747865820824	0.796462372713479	ACTG1	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/664	45/18367	0.487618520650461	0.796995284405193	APEX1/POP7	2
GO:0140223	general transcription initiation factor activity	2/664	45/18367	0.487618520650461	0.796995284405193	GTF2A2/TAF9	2
GO:1901681	sulfur compound binding	10/664	265/18367	0.490482361435599	0.799588432965326	GSTP1/PPIA/RPL22/RPL29/PDCD5/DBI/PRMT1/ACBD6/ECI2/METTL5	10
GO:0033293	monocarboxylic acid binding	3/664	73/18367	0.4945673745776	0.799997872055756	GSTP1/NDUFAB1/ADH5	3
GO:0106306	protein serine phosphatase activity	3/664	73/18367	0.4945673745776	0.799997872055756	DUSP9/DUSP14/PPP4C	3
GO:0106307	protein threonine phosphatase activity	3/664	73/18367	0.4945673745776	0.799997872055756	DUSP9/DUSP14/PPP4C	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	6/664	156/18367	0.497291352009354	0.802330892674885	COMT/PRMT1/LCMT1/DNMT1/METTL5/EMG1	6
GO:0061980	regulatory RNA binding	2/664	46/18367	0.4992722418531	0.803456101285451	HNRNPA1/YBX1	2
GO:0030627	pre-mRNA 5'-splice site binding	1/664	19/18367	0.503393427818479	0.804343716999608	SNRPC	1
GO:0017022	myosin binding	3/664	74/18367	0.503678493712215	0.804343716999608	MYL12B/RAB25/RAB11A	3
GO:0019210	kinase inhibitor activity	3/664	74/18367	0.503678493712215	0.804343716999608	NPM1/CDKN1C/PKIB	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/664	47/18367	0.510754488558459	0.804953377527684	DUSP9/DUSP14	2
GO:0035254	glutamate receptor binding	2/664	47/18367	0.510754488558459	0.804953377527684	GNAS/MYL12A	2
GO:0008168	methyltransferase activity	8/664	214/18367	0.512242998715382	0.804953377527684	GCSH/COMT/TRMT112/PRMT1/LCMT1/DNMT1/METTL5/EMG1	8
GO:0030414	peptidase inhibitor activity	7/664	187/18367	0.516744500932523	0.804953377527684	GAPDH/PRDX5/PEBP1/ANXA2/PRDX3/SERPINB1/SERPINB6	7
GO:0016018	cyclosporin A binding	1/664	20/18367	0.521365237494113	0.804953377527684	PPIA	1
GO:0016408	C-acyltransferase activity	1/664	20/18367	0.521365237494113	0.804953377527684	HADHB	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/664	20/18367	0.521365237494113	0.804953377527684	BAD	1
GO:0030296	protein tyrosine kinase activator activity	1/664	20/18367	0.521365237494113	0.804953377527684	CD24	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/664	20/18367	0.521365237494113	0.804953377527684	GNAS	1
GO:0042288	MHC class I protein binding	1/664	20/18367	0.521365237494113	0.804953377527684	TUBB4B	1
GO:0061608	nuclear import signal receptor activity	1/664	20/18367	0.521365237494113	0.804953377527684	NUTF2	1
GO:0070300	phosphatidic acid binding	1/664	20/18367	0.521365237494113	0.804953377527684	COMMD1	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/664	48/18367	0.522062414179296	0.804953377527684	ASS1/PAICS	2
GO:0120013	lipid transfer activity	2/664	48/18367	0.522062414179296	0.804953377527684	PRELID1/TRIAP1	2
GO:0034212	peptide N-acetyltransferase activity	2/664	49/18367	0.533193601133177	0.818814145757031	NAA10/TAF9	2
GO:0008234	cysteine-type peptidase activity	7/664	190/18367	0.533668005541324	0.818814145757031	EIF3F/EIF3H/UCHL3/PSMD14/CASP4/OTUB1/COPS5	7
GO:0140416	transcription regulator inhibitor activity	1/664	21/18367	0.538687605309227	0.824494965583315	MDFI	1
GO:0005048	signal sequence binding	2/664	50/18367	0.544146033629023	0.826784992844098	SRP14/AP2M1	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	2/664	50/18367	0.544146033629023	0.826784992844098	SLC25A6/SLC25A5	2
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/664	50/18367	0.544146033629023	0.826784992844098	APEX1/DNPH1	2
GO:0005540	hyaluronic acid binding	1/664	22/18367	0.555383965827851	0.837759909899361	C1QBP	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/664	22/18367	0.555383965827851	0.837759909899361	AKR1B1	1
GO:0016881	acid-amino acid ligase activity	1/664	22/18367	0.555383965827851	0.837759909899361	PAICS	1
GO:0020037	heme binding	5/664	139/18367	0.567869051866999	0.845731785288949	CYB5A/HEBP2/CYCS/CYC1/SDHC	5
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/664	23/18367	0.571476909228794	0.845731785288949	PARP1	1
GO:0004529	exodeoxyribonuclease activity	1/664	23/18367	0.571476909228794	0.845731785288949	APEX1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/664	23/18367	0.571476909228794	0.845731785288949	APEX1	1
GO:0019865	immunoglobulin binding	1/664	23/18367	0.571476909228794	0.845731785288949	LGALS3	1
GO:0047617	acyl-CoA hydrolase activity	1/664	23/18367	0.571476909228794	0.845731785288949	ACOT13	1
GO:0050750	low-density lipoprotein particle receptor binding	1/664	23/18367	0.571476909228794	0.845731785288949	AP2M1	1
GO:0070412	R-SMAD binding	1/664	23/18367	0.571476909228794	0.845731785288949	PARP1	1
GO:0050661	NADP binding	2/664	53/18367	0.575916140580952	0.848290597655708	GAPDH/GRHPR	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	2/664	53/18367	0.575916140580952	0.848290597655708	SLC25A6/SLC25A5	2
GO:0004622	lysophospholipase activity	1/664	24/18367	0.586988211685842	0.852562924629552	LYPLA2	1
GO:0015295	solute:proton symporter activity	1/664	24/18367	0.586988211685842	0.852562924629552	SLC25A3	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/664	24/18367	0.586988211685842	0.852562924629552	GAPDH	1
GO:0019789	SUMO transferase activity	1/664	24/18367	0.586988211685842	0.852562924629552	UBE2I	1
GO:0043274	phospholipase binding	1/664	24/18367	0.586988211685842	0.852562924629552	SRSF3	1
GO:0043495	protein-membrane adaptor activity	1/664	24/18367	0.586988211685842	0.852562924629552	PDCD6	1
GO:0031267	small GTPase binding	9/664	259/18367	0.595537316114723	0.862977684925502	SOD1/ANXA2/PFN1/CAV1/RANBP1/RAC1/NUTF2/LSM2/RANGRF	9
GO:0008013	beta-catenin binding	3/664	85/18367	0.597799119279126	0.863558506644079	SKP1/CBY1/TAX1BP3	3
GO:1901981	phosphatidylinositol phosphate binding	6/664	173/18367	0.598697111635032	0.863558506644079	PHLDA2/ANXA2/PFN1/SNX3/COMMD1/PHLDA3	6
GO:0016289	CoA hydrolase activity	1/664	25/18367	0.60193886465649	0.864251672648997	ACOT13	1
GO:0051019	mitogen-activated protein kinase binding	1/664	25/18367	0.60193886465649	0.864251672648997	PRMT1	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/664	56/18367	0.606038295183398	0.866164321426501	PRDX5/PRDX3	2
GO:0045309	protein phosphorylated amino acid binding	2/664	56/18367	0.606038295183398	0.866164321426501	PFN1/YWHAE	2
GO:0005548	phospholipid transporter activity	2/664	57/18367	0.615711658359307	0.876731686505115	PRELID1/TRIAP1	2
GO:0042974	retinoic acid receptor binding	1/664	26/18367	0.616349103118386	0.876731686505115	HMGA1	1
GO:0008276	protein methyltransferase activity	3/664	88/18367	0.621354391224423	0.876731686505115	TRMT112/PRMT1/LCMT1	3
GO:0019888	protein phosphatase regulator activity	3/664	89/18367	0.628994058301059	0.876731686505115	LGALS3/PPP1R14B/ENSA	3
GO:0043178	alcohol binding	3/664	89/18367	0.628994058301059	0.876731686505115	VDAC1/CAV1/VDAC2	3
GO:0046906	tetrapyrrole binding	5/664	149/18367	0.629549116026422	0.876731686505115	CYB5A/HEBP2/CYCS/CYC1/SDHC	5
GO:0016866	intramolecular transferase activity	1/664	27/18367	0.630238432791217	0.876731686505115	PGAM1	1
GO:0035255	ionotropic glutamate receptor binding	1/664	27/18367	0.630238432791217	0.876731686505115	GNAS	1
GO:0043425	bHLH transcription factor binding	1/664	27/18367	0.630238432791217	0.876731686505115	FHL2	1
GO:0051393	alpha-actinin binding	1/664	27/18367	0.630238432791217	0.876731686505115	PDLIM1	1
GO:0051959	dynein light intermediate chain binding	1/664	27/18367	0.630238432791217	0.876731686505115	DYNLL1	1
GO:0070006	metalloaminopeptidase activity	1/664	27/18367	0.630238432791217	0.876731686505115	METAP2	1
GO:0036002	pre-mRNA binding	2/664	59/18367	0.634509226726813	0.877798825477484	HNRNPA1/SNRPC	2
GO:0019903	protein phosphatase binding	5/664	150/18367	0.635415824446312	0.877798825477484	SOD1/SNX3/LGALS3/BAD/ENSA	5
GO:0140677	molecular function activator activity	5/664	150/18367	0.635415824446312	0.877798825477484	PARK7/GNAS/PDCD5/AHSA1/DNAJC19	5
GO:0004518	nuclease activity	7/664	210/18367	0.63945234240656	0.877798825477484	RPS3/NME1/REXO2/APEX1/POP7/EXOSC7/ERI3	7
GO:0005506	iron ion binding	5/664	151/18367	0.641225221947766	0.877798825477484	ADI1/ETHE1/NFU1/ISCU/CDO1	5
GO:0003785	actin monomer binding	1/664	28/18367	0.643625656380456	0.877798825477484	PFN1	1
GO:0017056	structural constituent of nuclear pore	1/664	28/18367	0.643625656380456	0.877798825477484	NUTF2	1
GO:0050681	androgen receptor binding	1/664	28/18367	0.643625656380456	0.877798825477484	PARK7	1
GO:0070325	lipoprotein particle receptor binding	1/664	28/18367	0.643625656380456	0.877798825477484	AP2M1	1
GO:0051213	dioxygenase activity	3/664	92/18367	0.651269477808396	0.886292811104469	ADI1/ETHE1/CDO1	3
GO:0004033	aldo-keto reductase (NADP) activity	1/664	29/18367	0.656528898878049	0.887661103018702	AKR1B1	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/664	29/18367	0.656528898878049	0.887661103018702	AKR1B1	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/664	29/18367	0.656528898878049	0.887661103018702	SNX3	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4/664	125/18367	0.666449146120551	0.89865340258185	HINT1/ATIC/NIT2/HINT2	4
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/664	30/18367	0.668965631953901	0.89865340258185	HSD17B10	1
GO:0046966	thyroid hormone receptor binding	1/664	30/18367	0.668965631953901	0.89865340258185	HMGN3	1
GO:0000146	microfilament motor activity	1/664	31/18367	0.680952697470758	0.905045411075785	MYL6	1
GO:0016878	acid-thiol ligase activity	1/664	31/18367	0.680952697470758	0.905045411075785	SUCLG1	1
GO:0043015	gamma-tubulin binding	1/664	31/18367	0.680952697470758	0.905045411075785	NME1	1
GO:0071813	lipoprotein particle binding	1/664	31/18367	0.680952697470758	0.905045411075785	HSPD1	1
GO:0071814	protein-lipid complex binding	1/664	31/18367	0.680952697470758	0.905045411075785	HSPD1	1
GO:0008173	RNA methyltransferase activity	2/664	65/18367	0.686573897362009	0.907446789049468	METTL5/EMG1	2
GO:0008237	metallopeptidase activity	6/664	190/18367	0.688072239286934	0.907446789049468	EIF3F/EIF3H/PSMD14/UQCRC2/METAP2/COPS5	6
GO:0001223	transcription coactivator binding	1/664	32/18367	0.692506330153973	0.907446789049468	RPL23	1
GO:0030332	cyclin binding	1/664	32/18367	0.692506330153973	0.907446789049468	XRCC6	1
GO:0051721	protein phosphatase 2A binding	1/664	32/18367	0.692506330153973	0.907446789049468	ENSA	1
GO:0071889	14-3-3 protein binding	1/664	32/18367	0.692506330153973	0.907446789049468	BAD	1
GO:0004722	protein serine/threonine phosphatase activity	3/664	98/18367	0.692906653619242	0.907446789049468	DUSP9/DUSP14/PPP4C	3
GO:0004623	phospholipase A2 activity	1/664	33/18367	0.70364217944646	0.917666675694759	PRDX6	1
GO:0005154	epidermal growth factor receptor binding	1/664	33/18367	0.70364217944646	0.917666675694759	ARF4	1
GO:0005496	steroid binding	3/664	100/18367	0.705924423443278	0.917940586174264	VDAC1/CAV1/VDAC2	3
GO:0015631	tubulin binding	12/664	375/18367	0.707609805943459	0.917940586174264	GAPDH/RPS3/ALDOA/NME1/TBCA/PDCD5/BEX4/CNN3/CACYBP/UXT/CCT5/RAB11A	12
GO:0008080	N-acetyltransferase activity	2/664	68/18367	0.710239670104177	0.917940586174264	NAA10/TAF9	2
GO:0016782	transferase activity, transferring sulphur-containing groups	2/664	68/18367	0.710239670104177	0.917940586174264	TSTD1/MOCS2	2
GO:0030295	protein kinase activator activity	3/664	101/18367	0.712273173277947	0.917940586174264	RPLP1/CD24/MAP2K2	3
GO:0005543	phospholipid binding	15/664	466/18367	0.714068946894475	0.917940586174264	PEBP1/ANXA5/PHLDA2/ANXA2/PFN1/ANXA3/VDAC1/SNX3/CHMP2A/VDAC2/STOML2/COMMD1/BAD/PHLDA3/NSFL1C	15
GO:0016229	steroid dehydrogenase activity	1/664	34/18367	0.714375330578104	0.917940586174264	HSD17B10	1
GO:0019902	phosphatase binding	6/664	196/18367	0.716282760826082	0.917940586174264	SOD1/SNX3/LGALS3/BAD/ENSA/SH2D4A	6
GO:0004521	endoribonuclease activity	2/664	69/18367	0.717789296164227	0.917940586174264	APEX1/POP7	2
GO:0004725	protein tyrosine phosphatase activity	3/664	102/18367	0.718515794289759	0.917940586174264	DUSP9/DUSP14/ACP1	3
GO:0031490	chromatin DNA binding	3/664	103/18367	0.724652832466478	0.919810148141357	HMGN3/HNRNPC/APEX1	3
GO:0001098	basal transcription machinery binding	2/664	70/18367	0.725172792880725	0.919810148141357	EDF1/RUVBL1	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/664	70/18367	0.725172792880725	0.919810148141357	EDF1/RUVBL1	2
GO:0140097	catalytic activity, acting on DNA	7/664	229/18367	0.725856570578004	0.919810148141357	RPS3/NME1/PTGES3/DNMT1/APEX1/XRCC6/RUVBL1	7
GO:0005484	SNAP receptor activity	1/664	36/18367	0.734691179355269	0.925385670576254	VAMP8	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/664	36/18367	0.734691179355269	0.925385670576254	ATIC	1
GO:0034061	DNA polymerase activity	1/664	36/18367	0.734691179355269	0.925385670576254	PTGES3	1
GO:0003730	mRNA 3'-UTR binding	6/664	201/18367	0.738411422824249	0.92764664143419	RPL5/RPS7/RPL41/HNRNPC/CCT5/RSL1D1	6
GO:0003678	DNA helicase activity	2/664	72/18367	0.739449958587317	0.92764664143419	XRCC6/RUVBL1	2
GO:0043531	ADP binding	1/664	37/18367	0.744301405579048	0.930005349086795	RUVBL1	1
GO:0071855	neuropeptide receptor binding	1/664	37/18367	0.744301405579048	0.930005349086795	GNAS	1
GO:0019208	phosphatase regulator activity	3/664	107/18367	0.74815797310564	0.931107139491314	LGALS3/PPP1R14B/ENSA	3
GO:0019209	kinase activator activity	3/664	107/18367	0.74815797310564	0.931107139491314	RPLP1/CD24/MAP2K2	3
GO:0019905	syntaxin binding	2/664	74/18367	0.75308888081848	0.933636589237942	VAMP8/RAB11A	2
GO:0019213	deacetylase activity	1/664	38/18367	0.753564027875585	0.933636589237942	ESD	1
GO:0019838	growth factor binding	4/664	141/18367	0.754664719096483	0.933636589237942	RPS2/RPS19/S100A13/SEC61B	4
GO:0004721	phosphoprotein phosphatase activity	5/664	174/18367	0.758341850652437	0.93633530277796	DUSP9/PHPT1/DUSP14/PPP4C/ACP1	5
GO:0004402	histone acetyltransferase activity	1/664	39/18367	0.762491600874145	0.937759807754842	TAF9	1
GO:0019825	oxygen binding	1/664	39/18367	0.762491600874145	0.937759807754842	PARK7	1
GO:0008047	enzyme activator activity	3/664	110/18367	0.764712637065836	0.938647276084732	PARK7/GNAS/PDCD5	3
GO:0004177	aminopeptidase activity	1/664	40/18367	0.771096226420826	0.940947831850754	METAP2	1
GO:0042287	MHC protein binding	1/664	40/18367	0.771096226420826	0.940947831850754	TUBB4B	1
GO:0043014	alpha-tubulin binding	1/664	40/18367	0.771096226420826	0.940947831850754	BEX4	1
GO:0001221	transcription coregulator binding	2/664	78/18367	0.7785266162131	0.945538509200818	RPL23/UBE2I	2
GO:0016877	ligase activity, forming carbon-sulfur bonds	1/664	41/18367	0.779389569884381	0.945538509200818	SUCLG1	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	1/664	41/18367	0.779389569884381	0.945538509200818	TAF9	1
GO:0052689	carboxylic ester hydrolase activity	4/664	147/18367	0.782721366551154	0.9477438596925	PRDX6/PTRHD1/LYPLA2/ESD	4
GO:0046332	SMAD binding	2/664	79/18367	0.784516738583671	0.948083935045131	PARP1/EID2	2
GO:0030547	signaling receptor inhibitor activity	1/664	43/18367	0.795086983401943	0.959006650500224	LY6E	1
GO:0001784	phosphotyrosine residue binding	1/664	44/18367	0.802512340475786	0.964247073201233	PFN1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/664	44/18367	0.802512340475786	0.964247073201233	MAP2K2	1
GO:0015103	inorganic anion transmembrane transporter activity	4/664	152/18367	0.80410406196127	0.964308702658535	CLIC3/VDAC1/VDAC2/VDAC3	4
GO:0030165	PDZ domain binding	2/664	84/18367	0.812374755866871	0.972364430540462	GNG5/MAP2K2	2
GO:0005085	guanyl-nucleotide exchange factor activity	6/664	223/18367	0.821046533238192	0.980868568334176	EEF1B2/LAMTOR5/EEF1D/ARF4/LAMTOR2/RANGRF	6
GO:0042277	peptide binding	9/664	321/18367	0.824598553113901	0.983235608093909	PPIA/CLTA/HSP90AB1/SRP14/PFDN4/PFDN2/PFDN6/AP2M1/PFDN1	9
GO:0043539	protein serine/threonine kinase activator activity	1/664	49/18367	0.835797912534244	0.994203101499958	MAP2K2	1
GO:0015297	antiporter activity	2/664	89/18367	0.836972898547089	0.994203101499958	SLC25A6/SLC25A5	2
GO:0016407	acetyltransferase activity	2/664	91/18367	0.84596841553436	0.999999958851285	NAA10/TAF9	2
GO:0051018	protein kinase A binding	1/664	51/18367	0.847486630092372	0.999999958851285	RPS3	1
GO:0004519	endonuclease activity	3/664	129/18367	0.849943498892917	0.999999958851285	RPS3/APEX1/POP7	3
GO:0016597	amino acid binding	1/664	52/18367	0.853015614456789	0.999999958851285	ASS1	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/664	52/18367	0.853015614456789	0.999999958851285	PSMD4	1
GO:0016410	N-acyltransferase activity	2/664	94/18367	0.85861797403843	0.999999958851285	NAA10/TAF9	2
GO:0008374	O-acyltransferase activity	1/664	54/18367	0.863480373004206	0.999999958851285	PRDX6	1
GO:0008170	N-methyltransferase activity	2/664	97/18367	0.870311280945485	0.999999958851285	PRMT1/METTL5	2
GO:0042054	histone methyltransferase activity	1/664	56/18367	0.873201120393139	0.999999958851285	PRMT1	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/664	58/18367	0.882230679363989	0.999999958851285	MPC2	1
GO:0031406	carboxylic acid binding	4/664	176/18367	0.884064165164853	0.999999958851285	GSTP1/NDUFAB1/ADH5/GRHPR	4
GO:0001786	phosphatidylserine binding	1/664	60/18367	0.890618127649894	0.999999958851285	ANXA2	1
GO:0004620	phospholipase activity	2/664	104/18367	0.894216857067979	0.999999958851285	PRDX6/LYPLA2	2
GO:0043621	protein self-association	1/664	61/18367	0.894585438691598	0.999999958851285	MDH2	1
GO:0051015	actin filament binding	5/664	217/18367	0.896853079487151	0.999999958851285	DSTN/ARPC2/CFL1/CTNNAL1/ARPC1A	5
GO:1990841	promoter-specific chromatin binding	1/664	62/18367	0.898409063115764	0.999999958851285	DNMT1	1
GO:0000149	SNARE binding	2/664	110/18367	0.911378554876993	0.999999958851285	VAMP8/RAB11A	2
GO:0004175	endopeptidase activity	11/664	430/18367	0.9123670293339	0.999999958851285	PSMB6/PSMB1/PSMB7/PSMB5/PSMB3/PSMB2/PSMA4/PSMB4/UQCRC2/CASP4/COPS5	11
GO:0004222	metalloendopeptidase activity	2/664	111/18367	0.913972092531156	0.999999958851285	UQCRC2/COPS5	2
GO:0008094	ATP-dependent activity, acting on DNA	2/664	111/18367	0.913972092531156	0.999999958851285	XRCC6/RUVBL1	2
GO:0003774	cytoskeletal motor activity	2/664	114/18367	0.921331755141343	0.999999958851285	DYNLRB1/MYL6	2
GO:0003777	microtubule motor activity	1/664	69/18367	0.921564896342944	0.999999958851285	DYNLRB1	1
GO:0005539	glycosaminoglycan binding	5/664	230/18367	0.922144287606413	0.999999958851285	PPIA/RPL22/RPL29/C1QBP/PDCD5	5
GO:0008235	metalloexopeptidase activity	1/664	72/18367	0.929798008401766	0.999999958851285	METAP2	1
GO:0035091	phosphatidylinositol binding	6/664	271/18367	0.929926810582748	0.999999958851285	PHLDA2/ANXA2/PFN1/SNX3/COMMD1/PHLDA3	6
GO:0005254	chloride channel activity	1/664	74/18367	0.934801500297004	0.999999958851285	CLIC3	1
GO:0016791	phosphatase activity	6/664	275/18367	0.935571950330972	0.999999958851285	DUSP9/PHPT1/DUSP14/PPP4C/ACP1/HDDC2	6
GO:0005244	voltage-gated ion channel activity	4/664	201/18367	0.935581171038942	0.999999958851285	CLIC3/VDAC1/VDAC2/VDAC3	4
GO:0022832	voltage-gated channel activity	4/664	201/18367	0.935581171038942	0.999999958851285	CLIC3/VDAC1/VDAC2/VDAC3	4
GO:0001618	virus receptor activity	1/664	76/18367	0.939448878030991	0.999999958851285	RPSA	1
GO:0008509	anion transmembrane transporter activity	7/664	314/18367	0.939670088781351	0.999999958851285	CLIC3/SLC25A6/VDAC1/SLC25A5/VDAC2/MPC2/VDAC3	7
GO:0016874	ligase activity	3/664	165/18367	0.94051983715233	0.999999958851285	SUCLG1/ASS1/PAICS	3
GO:0140272	exogenous protein binding	1/664	77/18367	0.941647005251341	0.999999958851285	RPSA	1
GO:0140101	catalytic activity, acting on a tRNA	2/664	124/18367	0.941803949119531	0.999999958851285	PTRHD1/POP7	2
GO:0008201	heparin binding	3/664	166/18367	0.942093954024223	0.999999958851285	RPL22/RPL29/PDCD5	3
GO:0035591	signaling adaptor activity	1/664	81/18367	0.949671032262764	0.999999958851285	MAP2K2	1
GO:0016298	lipase activity	2/664	129/18367	0.95003421747132	0.999999958851285	PRDX6/LYPLA2	2
GO:0050660	flavin adenine dinucleotide binding	1/664	85/18367	0.956593119201836	0.999999958851285	ETFA	1
GO:0042562	hormone binding	1/664	86/18367	0.958169651794002	0.999999958851285	SEC61B	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4/664	222/18367	0.961722994806695	0.999999958851285	PRDX6/NAA10/TAF9/HADHB	4
GO:0008081	phosphoric diester hydrolase activity	1/664	89/18367	0.962564398950698	0.999999958851285	APEX1	1
GO:0019955	cytokine binding	2/664	139/18367	0.96328471600184	0.999999958851285	PARK7/COPS5	2
GO:0070851	growth factor receptor binding	2/664	141/18367	0.965495580475413	0.999999958851285	ARF4/PDCL3	2
GO:0008514	organic anion transmembrane transporter activity	3/664	185/18367	0.965544357055184	0.999999958851285	SLC25A6/SLC25A5/MPC2	3
GO:0072341	modified amino acid binding	1/664	93/18367	0.967715303246173	0.999999958851285	ANXA2	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	2/664	144/18367	0.968573619750213	0.999999958851285	APEX1/DNPH1	2
GO:0008017	microtubule binding	5/664	271/18367	0.9697643775829	0.999999958851285	GAPDH/RPS3/CNN3/UXT/RAB11A	5
GO:0004497	monooxygenase activity	1/664	102/18367	0.976863585301954	0.999999958851285	PCBD1	1
GO:0005319	lipid transporter activity	2/664	154/18367	0.977037220954101	0.999999958851285	PRELID1/TRIAP1	2
GO:0008238	exopeptidase activity	1/664	103/18367	0.977704679162315	0.999999958851285	METAP2	1
GO:0005516	calmodulin binding	3/664	201/18367	0.978026823581398	0.999999958851285	EDF1/CNN3/NDUFAF4	3
GO:0004386	helicase activity	2/664	156/18367	0.978442661963037	0.999999958851285	XRCC6/RUVBL1	2
GO:0015294	solute:cation symporter activity	1/664	104/18367	0.978515240541872	0.999999958851285	SLC25A3	1
GO:0003779	actin binding	9/664	440/18367	0.979767153830452	0.999999958851285	ALDOA/PFN1/PDLIM1/DSTN/ARPC2/CFL1/CTNNAL1/CNN3/ARPC1A	9
GO:0042578	phosphoric ester hydrolase activity	7/664	366/18367	0.980048635565051	0.999999958851285	DUSP9/PHPT1/DUSP14/APEX1/PPP4C/ACP1/HDDC2	7
GO:0140030	modification-dependent protein binding	2/664	160/18367	0.981008001158255	0.999999958851285	HSPD1/PSMD4	2
GO:0016746	acyltransferase activity	4/664	250/18367	0.98148039043771	0.999999958851285	PRDX6/NAA10/TAF9/HADHB	4
GO:0019787	ubiquitin-like protein transferase activity	9/664	458/18367	0.98611045181749	0.999999958851285	ANAPC11/RBX1/UBE2L3/UBE2I/RNF181/UFC1/UBE2N/RNF7/NSMCE1	9
GO:0061630	ubiquitin protein ligase activity	5/664	304/18367	0.986625543430595	0.999999958851285	ANAPC11/RBX1/RNF181/RNF7/NSMCE1	5
GO:0004197	cysteine-type endopeptidase activity	1/664	119/18367	0.987675357775841	0.999999958851285	CASP4	1
GO:0005262	calcium channel activity	1/664	119/18367	0.987675357775841	0.999999958851285	ANXA2	1
GO:0016757	glycosyltransferase activity	4/664	270/18367	0.989183131238878	0.999999958851285	APRT/PNP/QPRT/PARP1	4
GO:0030246	carbohydrate binding	4/664	271/18367	0.989474048896646	0.999999958851285	ALDOA/UGP2/LGALS3/TALDO1	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	1/664	124/18367	0.98976053310302	0.999999958851285	MAP2K2	1
GO:0061659	ubiquitin-like protein ligase activity	5/664	316/18367	0.99015928088822	0.999999958851285	ANAPC11/RBX1/RNF181/RNF7/NSMCE1	5
GO:0015291	secondary active transmembrane transporter activity	3/664	240/18367	0.992946774042062	0.999999958851285	SLC25A6/SLC25A3/SLC25A5	3
GO:0015085	calcium ion transmembrane transporter activity	1/664	135/18367	0.993190662528293	0.999999958851285	ANXA2	1
GO:0043177	organic acid binding	1/664	135/18367	0.993190662528293	0.999999958851285	ASS1	1
GO:0004713	protein tyrosine kinase activity	1/664	136/18367	0.993438655073336	0.999999958851285	MAP2K2	1
GO:0042393	histone binding	3/664	244/18367	0.993739987657475	0.999999958851285	NPM1/RBBP7/PIH1D1	3
GO:0001664	G protein-coupled receptor binding	4/664	295/18367	0.99458226366782	0.999999958851285	GNAS/C1QBP/PHB/PSMC5	4
GO:0019199	transmembrane receptor protein kinase activity	1/664	143/18367	0.994939613048066	0.999999958851285	MAP2K2	1
GO:0005178	integrin binding	1/664	144/18367	0.995123990623575	0.999999958851285	PPIA	1
GO:0015293	symporter activity	1/664	144/18367	0.995123990623575	0.999999958851285	SLC25A3	1
GO:0004842	ubiquitin-protein transferase activity	7/664	433/18367	0.995864766691619	0.999999958851285	ANAPC11/RBX1/UBE2L3/RNF181/UBE2N/RNF7/NSMCE1	7
GO:0005126	cytokine receptor binding	3/664	271/18367	0.99723383910656	0.999999958851285	MIF/DDT/PDCL3	3
GO:0016887	ATP hydrolysis activity	3/664	272/18367	0.997317218420793	0.999999958851285	HSPD1/OLA1/RUVBL1	3
GO:0008083	growth factor activity	1/664	162/18367	0.997501008259612	0.999999958851285	NENF	1
GO:0046943	carboxylic acid transmembrane transporter activity	1/664	163/18367	0.99759215522559	0.999999958851285	MPC2	1
GO:0005342	organic acid transmembrane transporter activity	1/664	164/18367	0.997679982567394	0.999999958851285	MPC2	1
GO:0005096	GTPase activator activity	7/664	462/18367	0.997994122484045	0.999999958851285	EEF1B2/LAMTOR5/RANBP1/EEF1D/ARF4/LAMTOR2/RANGRF	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/664	170/18367	0.998143697067354	0.999999958851285	PCBD1	1
GO:0022836	gated channel activity	4/664	340/18367	0.998508993795471	0.999999958851285	CLIC3/VDAC1/VDAC2/VDAC3	4
GO:0030695	GTPase regulator activity	7/664	488/18367	0.998970777658611	0.999999958851285	EEF1B2/LAMTOR5/RANBP1/EEF1D/ARF4/LAMTOR2/RANGRF	7
GO:0060589	nucleoside-triphosphatase regulator activity	7/664	488/18367	0.998970777658611	0.999999958851285	EEF1B2/LAMTOR5/RANBP1/EEF1D/ARF4/LAMTOR2/RANGRF	7
GO:0005216	ion channel activity	5/664	432/18367	0.999592089478463	0.999999958851285	CLIC3/ANXA2/VDAC1/VDAC2/VDAC3	5
GO:0005125	cytokine activity	1/664	235/18367	0.999835019446633	0.999999958851285	MIF	1
GO:0015267	channel activity	5/664	480/18367	0.999900113837608	0.999999958851285	CLIC3/ANXA2/VDAC1/VDAC2/VDAC3	5
GO:0022803	passive transmembrane transporter activity	5/664	481/18367	0.999903042840695	0.999999958851285	CLIC3/ANXA2/VDAC1/VDAC2/VDAC3	5
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	1/664	310/18367	0.999990006684369	0.999999958851285	ENO1	1
GO:0004674	protein serine/threonine kinase activity	2/664	386/18367	0.999990898040426	0.999999958851285	CSNK2B/MAP2K2	2
GO:0001217	DNA-binding transcription repressor activity	1/664	313/18367	0.999991069134551	0.999999958851285	ENO1	1
GO:0005261	cation channel activity	1/664	335/18367	0.999996085679644	0.999999958851285	ANXA2	1
GO:0048018	receptor ligand activity	3/664	487/18367	0.999997508114158	0.999999958851285	MIF/LGALS3/NENF	3
GO:0030546	signaling receptor activator activity	3/664	495/18367	0.999998099701665	0.999999958851285	MIF/LGALS3/NENF	3
GO:0106310	protein serine kinase activity	1/664	360/18367	0.99999846881499	0.999999958851285	MAP2K2	1
GO:0046873	metal ion transmembrane transporter activity	1/664	430/18367	0.99999989020262	0.999999958851285	ANXA2	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	1/664	450/18367	0.999999948385194	0.999999958851285	TFDP2	1
GO:0001216	DNA-binding transcription activator activity	1/664	456/18367	0.999999958851285	0.999999958851285	TFDP2	1