ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	61/1007	332/18367	4.70751183142344e-17	4.43918365703231e-14	EGFR/ITGA6/CDH1/CD46/AHNAK/HSPA5/ITGB1/DLG1/CTNND1/ANK3/DOCK9/SLK/MPP7/IDH1/LIMA1/KTN1/PPFIBP1/FNBP1L/ARGLU1/SND1/CALD1/FMNL2/WASF2/ERC1/CD2AP/MACF1/TJP1/BSG/EPN2/RTN4/EZR/CTNNAL1/P2RX4/TRIM29/SWAP70/PTPN1/UBAP2/PKN2/PTPRM/PDXDC1/CTNNB1/PKP2/CAST/USO1/HDLBP/ARHGAP18/RDX/ESYT2/PPP1R13L/SPTAN1/GOLGA2/SPTBN1/COBLL1/PLEC/FASN/GAPVD1/PHLDB2/CLINT1/CTNNA1/ANXA2/KRT18	61
GO:0051020	GTPase binding	38/1007	291/18367	6.13135260707422e-07	0.00028909327542355	GOLGA4/RASA1/RHOBTB3/DIAPH2/IQGAP2/EXPH5/TRIP11/CHML/CCDC186/FNBP1L/DVL3/ABCA1/PPP1R9A/FMNL2/TNPO1/CDKL5/ERC1/MYCBP2/TRIOBP/HSP90AA1/PKN2/ERRFI1/GCC2/MYO1C/RANBP17/RAB11FIP4/IPO7/RANBP2/RAB11FIP1/NCKAP1/EPS8/DAAM1/SPTBN1/INF2/MICAL3/EVI5/CDC42BPB/ANXA2	38
GO:0003779	actin binding	49/1007	440/18367	1.93474717915198e-06	0.000608155529980106	EGFR/SYNE2/MYH10/DAG1/SLC6A4/UTRN/DST/ITGB1/P4HB/DIAPH2/IQGAP2/LIMA1/SCIN/RAI14/DMD/PPP1R9A/CALD1/FERMT1/PHACTR2/FMNL2/COBL/WASF2/MYO7A/FERMT2/MACF1/EPB41L3/PAWR/EZR/CTNNAL1/ACTN4/SORBS1/TRIOBP/TRPM7/MYO1C/RDX/PTK2/EPS8/DAAM1/SPTAN1/SPTBN1/COBLL1/PLEC/ADD3/INF2/OPHN1/MYO6/MICAL3/CTNNA1/HNRNPU	49
GO:0005178	integrin binding	23/1007	144/18367	3.57778166860817e-06	0.000843462028374377	EGFR/FBN1/LAMB1/ITGB4/FBLN1/ITGAV/LAMA5/UTRN/ITGB8/DST/ITGB5/ITGB1/P4HB/CALR/PLPP3/FERMT1/FERMT2/S1PR2/ACTN4/JAM3/MMP14/PTK2/LGALS8	23
GO:0031267	small GTPase binding	33/1007	259/18367	5.66859690167401e-06	0.00106909737565572	GOLGA4/RHOBTB3/DIAPH2/IQGAP2/EXPH5/TRIP11/CHML/CCDC186/DVL3/ABCA1/FMNL2/TNPO1/CDKL5/ERC1/MYCBP2/TRIOBP/PKN2/ERRFI1/GCC2/MYO1C/RANBP17/RAB11FIP4/IPO7/RANBP2/RAB11FIP1/NCKAP1/EPS8/DAAM1/INF2/MICAL3/EVI5/CDC42BPB/ANXA2	33
GO:0001618	virus receptor activity	15/1007	76/18367	1.33475862470893e-05	0.00195819424139173	EGFR/CD46/DAG1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/CD55/SLC52A1/BSG/SLC1A5/SLC20A2/HSPA1B/SLC52A2	15
GO:0140272	exogenous protein binding	15/1007	77/18367	1.57470745791502e-05	0.00195819424139173	EGFR/CD46/DAG1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/CD55/SLC52A1/BSG/SLC1A5/SLC20A2/HSPA1B/SLC52A2	15
GO:0003712	transcription coregulator activity	50/1007	489/18367	1.66124644020507e-05	0.00195819424139173	MAGED1/SMARCA2/NCOA3/BRD4/TBL1X/TLE4/PTPN14/YAP1/TRIP11/ZNF451/FUS/RERE/CBX4/TFAP2A/RCOR1/SND1/N4BP2L2/DNMT3A/SF1/KDM5B/DDX17/ARID3A/CCND1/DCAF6/SIAH2/BCLAF1/PAWR/CCAR1/ACTN4/NSD1/BRD7/TRIM24/ARID5B/CTNNB1/DDX1/TCERG1/KMT2C/PPP1R13L/SMARCC1/USP22/MAML2/TLE1/RBFOX2/BRD8/EID2/TMF1/XPC/HNRNPU/PAGE4/SRSF2	50
GO:0003714	transcription corepressor activity	25/1007	187/18367	3.34446259032418e-05	0.00350425358075078	TBL1X/TLE4/YAP1/ZNF451/RERE/CBX4/TFAP2A/RCOR1/N4BP2L2/DNMT3A/SF1/KDM5B/CCND1/SIAH2/PAWR/CCAR1/NSD1/BRD7/TCERG1/PPP1R13L/TLE1/RBFOX2/EID2/HNRNPU/SRSF2	25
GO:0098631	cell adhesion mediator activity	12/1007	59/18367	7.07028268757844e-05	0.00666727657438647	DSP/DSC2/ITGB1/BCAM/DSG2/CD47/BSG/TRIM29/JAM3/PKP2/ANXA2/KRT18	12
GO:0046332	SMAD binding	14/1007	79/18367	8.9397167655613e-05	0.00766377537265846	PARP1/TGFBR3/TRIM33/USP9X/FERMT2/TGFBR1/PPARG/PURA/CTNNB1/IPO7/COL5A2/PURB/EID2/YY1	14
GO:0097718	disordered domain specific binding	9/1007	36/18367	0.000106105107611193	0.00833809303977956	NCOA3/GJA1/GJA5/CLTC/MDM2/EZR/HSP90AA1/CTNNB1/AP2A2	9
GO:0070717	poly-purine tract binding	8/1007	29/18367	0.000121306495002205	0.00879938652208303	FMR1/RBMS3/LARP4/DDX1/ZC3H14/TIA1/HNRNPDL/HNRNPU	8
GO:0008143	poly(A) binding	7/1007	23/18367	0.000164635589011998	0.0107913316548921	RBMS3/LARP4/DDX1/ZC3H14/TIA1/HNRNPDL/HNRNPU	7
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	5/1007	11/18367	0.000171654268105388	0.0107913316548921	DSP/DSC2/DSG2/CD47/PKP2	5
GO:0050840	extracellular matrix binding	11/1007	56/18367	0.000195102016572236	0.0114988251017262	ITGA6/ADGRG1/DAG1/TINAGL1/ITGAV/ITGB1/BCAM/SMOC1/ADGRG6/GPC1/ANXA2	11
GO:0019838	growth factor binding	19/1007	141/18367	0.000255388247068362	0.013320072439504	EGFR/LRP2/ITGA6/NRP2/ITGB4/CRIM1/NRP1/ITGAV/GLG1/IGF1R/TGFBR3/IL6ST/ERBB3/TGFBR1/FGFR2/NRDC/LTBP3/LIFR/GPC1	19
GO:0098632	cell-cell adhesion mediator activity	10/1007	49/18367	0.000272744934408791	0.013320072439504	DSP/DSC2/DSG2/CD47/BSG/TRIM29/JAM3/PKP2/ANXA2/KRT18	10
GO:0017154	semaphorin receptor activity	5/1007	12/18367	0.000280991212093949	0.013320072439504	MET/NRP2/NRP1/PLXNB1/PLXNA1	5
GO:0008022	protein C-terminus binding	23/1007	189/18367	0.000282504187476226	0.013320072439504	FBLN1/DST/BCAM/TBL1X/DLG1/YAP1/PRRC2C/PPP1R9A/SIAH1/CD2AP/HIC2/EZR/TOP2B/PPARG/CTNNB1/MYO1C/AGO2/FIGN/ATXN2/CDK7/NIPBL/GPSM2/POLR2A	23
GO:0051082	unfolded protein binding	17/1007	122/18367	0.000355642830384204	0.0157297553754545	HSP90B1/LMAN1/HSPA5/CALR/SERPINH1/SIL1/CANX/HSPD1/ERLEC1/DNAJB4/AFG3L2/HSP90AA1/RP2/HSPA1B/PPIB/HSPA9/TOMM20	17
GO:0051015	actin filament binding	25/1007	217/18367	0.000366972023605514	0.0157297553754545	EGFR/SYNE2/MYH10/SLC6A4/UTRN/IQGAP2/LIMA1/SCIN/DMD/PPP1R9A/FERMT1/FMNL2/MYO7A/FERMT2/MACF1/EZR/CTNNAL1/ACTN4/TRIOBP/MYO1C/SPTAN1/SPTBN1/ADD3/MYO6/CTNNA1	25
GO:0031994	insulin-like growth factor I binding	5/1007	13/18367	0.000436043567503933	0.0178777862676613	LRP2/ITGA6/ITGB4/ITGAV/IGF1R	5
GO:0008514	organic anion transmembrane transporter activity	22/1007	185/18367	0.000522812100244773	0.0203121518046716	SLC26A2/SLC2A1/GJA1/SLC38A9/SLC38A1/SLC35B4/SLC16A12/SLC22A11/SLC19A1/SLC13A3/SLC52A1/SLC16A1/SLC1A5/SLC7A2/SLC35D1/SLC1A3/SLC5A6/SLC38A2/SLC52A3/SERINC3/SLC52A2/SLC29A1	22
GO:0008375	acetylglucosaminyltransferase activity	9/1007	44/18367	0.000538498192064465	0.0203121518046716	EXTL2/GCNT2/HEXB/B3GNT3/HEXA/B3GNT2/GCNT4/EXT2/B4GAT1	9
GO:0008509	anion transmembrane transporter activity	32/1007	314/18367	0.0005602761722608	0.0203207857862282	SLC26A2/SLC2A1/SLC6A4/SLC13A4/GJA1/SLC38A9/GABRE/CLDN4/SLC38A1/FXYD3/ANO6/SLC35B4/SLC16A12/SLC22A11/SLC19A1/SLC13A3/SLC52A1/ANKH/SLC16A1/SLC12A9/SLC9A1/SLC1A5/SLC7A2/SLC35D1/SLC1A3/SLC5A6/GABRA4/SLC38A2/SLC52A3/SERINC3/SLC52A2/SLC29A1	32
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	14/1007	94/18367	0.000583841012786693	0.0203285177034748	AGL/HEXB/FUCA1/GANAB/MANBA/MAN1A2/HEXA/GM2A/MOGS/EDEM3/GAA/GUSB/MAN2A1/GLB1	14
GO:0046943	carboxylic acid transmembrane transporter activity	20/1007	163/18367	0.000617391189462047	0.0203285177034748	SLC26A2/SLC27A2/SLC38A9/SLC43A2/SLC38A1/SLC16A12/SLC19A1/SLC13A3/SLC16A4/SLC7A6/SLC16A1/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC5A6/SLC38A2/ABCB1/SERINC3/SLC38A10	20
GO:0043236	laminin binding	7/1007	28/18367	0.000625161201909617	0.0203285177034748	ITGA6/DAG1/TINAGL1/ITGB1/BCAM/ADGRG6/GPC1	7
GO:0005342	organic acid transmembrane transporter activity	20/1007	164/18367	0.000667773316336202	0.0209903412435013	SLC26A2/SLC27A2/SLC38A9/SLC43A2/SLC38A1/SLC16A12/SLC19A1/SLC13A3/SLC16A4/SLC7A6/SLC16A1/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC5A6/SLC38A2/ABCB1/SERINC3/SLC38A10	20
GO:0008013	beta-catenin binding	13/1007	85/18367	0.000701101622457064	0.0213270590315165	CDH1/KANK1/DLG5/GJA1/TBL1X/FOXO4/DVL3/GLI3/CD2AP/CTNNB1/TCF7L2/GSK3B/CTNNA1	13
GO:0002039	p53 binding	11/1007	66/18367	0.000853479115250842	0.0251509626775483	BRD4/PTTG1IP/HSPD1/MDM2/USP10/TP63/SMYD2/TRIM29/BRD7/TRIM24/GSK3B	11
GO:0015293	symporter activity	18/1007	144/18367	0.000910104053060093	0.0251849563894398	SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC16A12/SLC13A3/SLC16A4/SLC16A1/SLC16A2/SLC12A9/SLC1A5/SLC1A3/SLC5A6/SLC22A5/SLC20A2/SLC38A2/SLC17A5/SLC45A4	18
GO:0016757	glycosyltransferase activity	28/1007	270/18367	0.000923012700035675	0.0251849563894398	GALNT11/AGL/EXTL2/RPN2/C1GALT1/PARP1/CHPF/GCNT2/FUT8/GXYLT1/HEXB/B4GALT1/QPRT/STT3B/DPY19L1/B3GNT3/TMTC3/HEXA/GLT8D1/B3GNT2/GCNT4/TNKS2/EXT2/GALNT18/STT3A/B4GAT1/RPN1/PNP	28
GO:0072349	modified amino acid transmembrane transporter activity	6/1007	22/18367	0.000934754478929367	0.0251849563894398	GJA1/SLC16A12/SLC19A1/SLC13A3/SLC5A6/SLC22A5	6
GO:0044325	transmembrane transporter binding	17/1007	133/18367	0.000971465496115596	0.0254469989676946	TCAF1/AKAP9/DLG1/SLC5A3/ANK3/PPP1R9A/USP10/HOMER1/YES1/FMR1/ACTN4/CTNNB1/PKP2/GOPC/ATP2A2/GPD1L/PRKCSH	17
GO:0090482	vitamin transmembrane transporter activity	7/1007	31/18367	0.00120246236916251	0.0301653720066297	SLC2A1/SLC19A1/SLC52A1/SLC19A3/SLC5A6/SLC52A3/SLC52A2	7
GO:0016758	hexosyltransferase activity	22/1007	197/18367	0.00121557172455136	0.0301653720066297	GALNT11/AGL/EXTL2/RPN2/C1GALT1/CHPF/GCNT2/FUT8/HEXB/B4GALT1/STT3B/DPY19L1/B3GNT3/TMTC3/HEXA/B3GNT2/GCNT4/EXT2/GALNT18/STT3A/B4GAT1/RPN1	22
GO:0005516	calmodulin binding	22/1007	201/18367	0.0015775284398734	0.0374498761573731	EGFR/MYH10/ATP2B1/IQGAP2/EEA1/ATP2B4/KCNN4/CAMK2G/PHKB/CALD1/SYT7/MYO7A/SLC9A1/TJP1/TRPV6/CAMSAP2/MYO1C/SPTAN1/SPTBN1/UBR4/ADD3/MYO6	22
GO:0015291	secondary active transmembrane transporter activity	25/1007	240/18367	0.00158854193668603	0.0374498761573731	SLC26A2/SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC16A12/SLC22A11/SLC19A1/SLC13A3/SLC16A4/ANKH/SLC7A6/SLC16A1/SLC16A2/SLC12A9/SLC9A1/SLC1A5/SLC35D1/SLC1A3/SLC5A6/SLC22A5/SLC20A2/SLC38A2/SLC17A5/SLC45A4	25
GO:0022804	active transmembrane transporter activity	37/1007	406/18367	0.00173828381262497	0.0399805276903743	SLC26A2/ATP2B1/SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC16A12/ATP13A3/SLC22A11/SLC19A1/ATP2B4/SLC13A3/SLC16A4/ABCA1/ANKH/SLC7A6/ATP6V1C2/SLC16A1/SLC16A2/SLC12A9/SLC9A1/SLC1A5/SLC35D1/SLC1A3/SLC5A6/SLC22A5/SLC20A2/SLC38A2/CYB5A/SLC17A5/ABCB1/ATP2A2/SLC45A4/UQCRC1/NDUFB9/COX6A1/TOMM20	37
GO:0070063	RNA polymerase binding	11/1007	73/18367	0.00199542845817048	0.0435914842451836	NCOA3/BRD4/SMYD2/NEDD4/PKN2/TCERG1/AGO2/STOM/PABPN1/PPIB/HNRNPU	11
GO:0030165	PDZ domain binding	12/1007	84/18367	0.00202977871276677	0.0435914842451836	CRIM1/ATP2B1/ADRB1/GJA1/CADM1/TGFBR3/ATP2B4/GNG12/ERC1/KIDINS220/SLC22A5/PLEKHA1	12
GO:0019199	transmembrane receptor protein kinase activity	17/1007	143/18367	0.00216040234374829	0.0435914842451836	EGFR/MET/NRP2/EFEMP1/CRIM1/NRP1/IGF1R/TGFBR3/EPHB4/ERBB3/YES1/TGFBR1/WEE1/FGFR2/BAZ1B/DDR1/PTK2	17
GO:0046975	histone methyltransferase activity (H3-K36 specific)	4/1007	11/18367	0.00217264025400173	0.0435914842451836	ASH1L/SMYD2/SETD2/NSD1	4
GO:0061665	SUMO ligase activity	4/1007	11/18367	0.00217264025400173	0.0435914842451836	ZNF451/CBX4/RANBP2/KIAA1586	4
GO:0097493	structural molecule activity conferring elasticity	4/1007	11/18367	0.00217264025400173	0.0435914842451836	FBN2/FBN1/AHNAK/LAMC1	4
GO:0019902	phosphatase binding	21/1007	196/18367	0.00258269867942392	0.0507392678061823	EGFR/MET/HSP90B1/DLG1/ATP2B4/KCNN4/PPP1R9A/SH2D4A/SLC9A1/PARD3/PTPN1/VCP/SH3YL1/MAPK14/CTNNB1/PTK2/BOD1L1/BCL2/ANAPC5/ELL/PPP6R2	21
GO:0003727	single-stranded RNA binding	12/1007	87/18367	0.00274262954514896	0.052781625736234	MSI2/L1TD1/CBX4/FMR1/RBMS3/LARP4/DDX1/AGO2/ZC3H14/TIA1/HNRNPDL/HNRNPU	12
GO:0035255	ionotropic glutamate receptor binding	6/1007	27/18367	0.00293290132927601	0.0553145190701456	FUS/CANX/FLOT2/OPHN1/SHANK2/GNAS	6
GO:0017166	vinculin binding	4/1007	12/18367	0.00311846477495562	0.0565521592842914	DAG1/UTRN/DMD/CTNNA1	4
GO:0045295	gamma-catenin binding	4/1007	12/18367	0.00311846477495562	0.0565521592842914	CDH1/DSC3/TCF7L2/CTNNA1	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	15/1007	124/18367	0.00324143345409914	0.0576730518342545	EGFR/MET/NRP2/EFEMP1/CRIM1/NRP1/IGF1R/EPHB4/ERBB3/YES1/WEE1/FGFR2/BAZ1B/DDR1/PTK2	15
GO:0015101	organic cation transmembrane transporter activity	6/1007	28/18367	0.00356228500037594	0.061297872005359	ATP13A3/SLC19A3/SLC44A1/SLC44A2/SLC22A5/SLC29A1	6
GO:0019903	protein phosphatase binding	17/1007	150/18367	0.0035751675082659	0.061297872005359	EGFR/MET/HSP90B1/ATP2B4/KCNN4/PPP1R9A/SLC9A1/PARD3/PTPN1/VCP/MAPK14/CTNNB1/PTK2/BOD1L1/BCL2/ANAPC5/PPP6R2	17
GO:0003756	protein disulfide isomerase activity	5/1007	20/18367	0.00381165420403112	0.0630594721824798	P4HB/PDIA3/PDIA6/PDIA4/PDIA5	5
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	5/1007	20/18367	0.00381165420403112	0.0630594721824798	P4HB/PDIA3/PDIA6/PDIA4/PDIA5	5
GO:0030246	carbohydrate binding	26/1007	271/18367	0.00404071977566412	0.0656965301457115	GALNT11/COLEC12/AGL/LMAN1/OLR1/CALR/CANX/GANAB/MANBA/SIGLEC6/UGP2/BSG/RPIA/PLA2R1/MLEC/CRYBG3/GAA/GUSB/MAN2A1/P3H2/CLEC1A/LGALS8/P3H1/GALNT18/CHID1/EMC7	26
GO:0005518	collagen binding	10/1007	69/18367	0.00419798197012206	0.0670965592851712	CTSL/ADGRG1/COL14A1/ITGB1/PCOLCE2/SERPINH1/DDR1/ADGRG6/P3H1/PPIB	10
GO:0005520	insulin-like growth factor binding	6/1007	29/18367	0.00428666927647761	0.0673721521286397	LRP2/ITGA6/ITGB4/CRIM1/ITGAV/IGF1R	6
GO:0003713	transcription coactivator activity	25/1007	262/18367	0.00509414542661053	0.0787504776605529	MAGED1/SMARCA2/NCOA3/BRD4/YAP1/TRIP11/FUS/RERE/DDX17/DCAF6/CCAR1/ACTN4/BRD7/TRIM24/ARID5B/CTNNB1/TCERG1/KMT2C/SMARCC1/USP22/MAML2/BRD8/TMF1/XPC/PAGE4	25
GO:0015179	L-amino acid transmembrane transporter activity	9/1007	61/18367	0.00573580300326056	0.0851028074786687	SLC38A9/SLC43A2/SLC38A1/SLC7A6/SLC1A5/SLC7A2/SLC1A3/SLC38A2/SERINC3	9
GO:0015926	glucosidase activity	4/1007	14/18367	0.00577580029547698	0.0851028074786687	AGL/GANAB/MOGS/GAA	4
GO:0044548	S100 protein binding	4/1007	14/18367	0.00577580029547698	0.0851028074786687	AHNAK/EZR/ATP2A2/ANXA2	4
GO:0000062	fatty-acyl-CoA binding	5/1007	22/18367	0.00591109510433766	0.0857563489752372	HADHA/ACADVL/ECI2/ACBD6/ACBD3	5
GO:0015171	amino acid transmembrane transporter activity	11/1007	84/18367	0.00603905470585681	0.0862852816306511	SLC38A9/SLC43A2/SLC38A1/SLC7A6/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC38A2/SERINC3/SLC38A10	11
GO:0051018	protein kinase A binding	8/1007	51/18367	0.00619267556288128	0.0871595978477172	AKAP9/WASF2/EZR/CRYBG3/RDX/ACBD3/ARFGEF1/GSK3B	8
GO:0140030	modification-dependent protein binding	17/1007	160/18367	0.00684813170923729	0.0949674735560406	MORC4/AGL/BRD4/CBX4/HSPD1/ATRX/BPTF/RAD23B/MPHOSPH8/FMR1/SUZ12/BRD7/VCP/TRIM24/PRPF8/OTUD7B/TAB3	17
GO:0017134	fibroblast growth factor binding	5/1007	23/18367	0.00721791009277617	0.0958660453167314	ITGAV/GLG1/TGFBR3/FGFR2/GPC1	5
GO:0030215	semaphorin receptor binding	5/1007	23/18367	0.00721791009277617	0.0958660453167314	SEMA6A/SEMA6D/PLXNB1/SEMA3F/SEMA4B	5
GO:1901567	fatty acid derivative binding	5/1007	23/18367	0.00721791009277617	0.0958660453167314	HADHA/ACADVL/ECI2/ACBD6/ACBD3	5
GO:0032794	GTPase activating protein binding	4/1007	15/18367	0.00753862592344066	0.0973825239151307	CDH1/PLXNB1/GNAI1/GAPVD1	4
GO:0042813	Wnt-activated receptor activity	4/1007	15/18367	0.00753862592344066	0.0973825239151307	LRP5/RYK/FZD6/FZD5	4
GO:0004713	protein tyrosine kinase activity	15/1007	136/18367	0.00766579182416954	0.0976870498674578	EGFR/MET/NRP2/EFEMP1/CRIM1/NRP1/IGF1R/EPHB4/ERBB3/YES1/WEE1/FGFR2/BAZ1B/DDR1/PTK2	15
GO:0019789	SUMO transferase activity	5/1007	24/18367	0.00871343442076099	0.109556915450368	ZNF451/CBX4/MDM2/RANBP2/KIAA1586	5
GO:0038024	cargo receptor activity	10/1007	77/18367	0.00915069189271535	0.113540821774086	LRP2/COLEC12/TFRC/OLR1/LRP1/FOLR1/ABCA1/PRSS12/MIA3/LGALS3BP	10
GO:0015923	mannosidase activity	4/1007	16/18367	0.00962172734423552	0.116324216482232	MANBA/MAN1A2/EDEM3/MAN2A1	4
GO:0140327	flippase activity	4/1007	16/18367	0.00962172734423552	0.116324216482232	ATP10D/TMEM30B/ABCB1/TMEM30A	4
GO:0008201	heparin binding	17/1007	166/18367	0.00976379635721701	0.116547594491844	FBN1/APP/NRP2/ADGRG1/APLP2/NRP1/BMP7/CCDC80/LRPAP1/ADAMTS1/PCOLCE2/TGFBR3/SMOC1/FSTL1/FGFR2/NAV2/SOD3	17
GO:0034237	protein kinase A regulatory subunit binding	5/1007	25/18367	0.0104100306616104	0.121193319924675	AKAP9/WASF2/EZR/ACBD3/ARFGEF1	5
GO:0120227	acyl-CoA binding	5/1007	25/18367	0.0104100306616104	0.121193319924675	HADHA/ACADVL/ECI2/ACBD6/ACBD3	5
GO:0015294	solute:cation symporter activity	12/1007	104/18367	0.0114812799031899	0.131041597891149	SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC13A3/SLC12A9/SLC1A3/SLC5A6/SLC20A2/SLC38A2/SLC17A5/SLC45A4	12
GO:0030695	GTPase regulator activity	39/1007	488/18367	0.0119484786799392	0.131041597891149	NRP1/RASA1/ADRB1/HACD3/NF1/DOCK9/IQGAP2/CHML/ARHGAP21/FAM13A/NET1/VAV3/ARHGAP5/DENND4C/PLXNB1/SYDE2/DOCK8/ARHGAP23/ARHGAP32/MYCBP2/CYTH3/SWAP70/ERRFI1/ARFGEF3/DOCK1/ARHGAP18/IPO7/RP2/CHN2/RANBP2/SRGAP1/ARFGEF1/GPSM2/OPHN1/GAPVD1/RABEP1/EVI5/HERC2/AGFG1	39
GO:0060589	nucleoside-triphosphatase regulator activity	39/1007	488/18367	0.0119484786799392	0.131041597891149	NRP1/RASA1/ADRB1/HACD3/NF1/DOCK9/IQGAP2/CHML/ARHGAP21/FAM13A/NET1/VAV3/ARHGAP5/DENND4C/PLXNB1/SYDE2/DOCK8/ARHGAP23/ARHGAP32/MYCBP2/CYTH3/SWAP70/ERRFI1/ARFGEF3/DOCK1/ARHGAP18/IPO7/RP2/CHN2/RANBP2/SRGAP1/ARFGEF1/GPSM2/OPHN1/GAPVD1/RABEP1/EVI5/HERC2/AGFG1	39
GO:0034185	apolipoprotein binding	4/1007	17/18367	0.0120454154063708	0.131041597891149	LRP1/CANX/HSPD1/ABCA1	4
GO:0070064	proline-rich region binding	4/1007	17/18367	0.0120454154063708	0.131041597891149	YAP1/CCND1/NEDD4/GAREM1	4
GO:0022853	active ion transmembrane transporter activity	24/1007	267/18367	0.012089733845737	0.131041597891149	SLC26A2/ATP2B1/SLC6A4/SLC13A4/SLC38A1/SLC5A3/ATP13A3/SLC22A11/SLC19A1/ATP2B4/SLC13A3/ATP6V1C2/SLC12A9/SLC9A1/SLC1A3/SLC5A6/SLC20A2/SLC38A2/CYB5A/SLC17A5/ATP2A2/SLC45A4/UQCRC1/COX6A1	24
GO:0016798	hydrolase activity, acting on glycosyl bonds	15/1007	144/18367	0.0126561982960845	0.135181923737823	AGL/HEXB/FUCA1/GANAB/MANBA/TLR3/MAN1A2/HEXA/GM2A/MOGS/EDEM3/GAA/GUSB/MAN2A1/GLB1	15
GO:0031625	ubiquitin protein ligase binding	26/1007	297/18367	0.0127584212223396	0.135181923737823	EGFR/HSPA5/CALR/HSPD1/MDM2/ERBB3/PSMD1/USP25/LRPPRC/GABARAPL1/RTN4/TRIOBP/HSP90AA1/VCP/FZD6/FZD5/BCL2/ABCB1/HSPA1B/GSK3B/POLR2A/ATF6/CUL5/HERC2/HSPA9/UQCRC1	26
GO:0016853	isomerase activity	16/1007	158/18367	0.0131977382421553	0.138282968470582	DEGS1/P4HB/PDIA3/ISYNA1/PDIA6/NKTR/HSPD1/PDIA4/ECI2/RPIA/GLCE/TOP2B/FKBP14/CYP2J2/PDIA5/PPIB	16
GO:0035254	glutamate receptor binding	7/1007	47/18367	0.0134566166201444	0.139446038162595	FUS/CANX/HOMER1/FLOT2/OPHN1/SHANK2/GNAS	7
GO:0005096	GTPase activator activity	37/1007	462/18367	0.0136575814263083	0.13999020961966	NRP1/RASA1/ADRB1/HACD3/NF1/DOCK9/IQGAP2/CHML/ARHGAP21/FAM13A/NET1/VAV3/ARHGAP5/DENND4C/PLXNB1/SYDE2/DOCK8/ARHGAP23/ARHGAP32/MYCBP2/CYTH3/SWAP70/ERRFI1/ARFGEF3/DOCK1/ARHGAP18/RP2/CHN2/RANBP2/SRGAP1/ARFGEF1/OPHN1/GAPVD1/RABEP1/EVI5/HERC2/AGFG1	37
GO:1901981	phosphatidylinositol phosphate binding	17/1007	173/18367	0.0143303161477534	0.142677823131353	IQGAP2/SCIN/SYT7/EXOC1/PLEKHA8/SLC9A1/FERMT2/ARHGAP32/CYTH3/SNX13/PARD3/PLEKHA5/SNX14/ZFYVE16/TTPA/PHLDA2/ANXA2	17
GO:0045499	chemorepellent activity	5/1007	27/18367	0.01445275814362	0.142677823131353	SEMA6A/SEMA6D/DPP4/SEMA3F/SEMA4B	5
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	5/1007	27/18367	0.01445275814362	0.142677823131353	ATP10D/ABCA1/TMEM30B/ABCB1/TMEM30A	5
GO:0004300	enoyl-CoA hydratase activity	3/1007	10/18367	0.0147489205195792	0.142677823131353	HADHA/ECHDC2/ECHDC1	3
GO:0015924	mannosyl-oligosaccharide mannosidase activity	3/1007	10/18367	0.0147489205195792	0.142677823131353	MAN1A2/EDEM3/MAN2A1	3
GO:0046624	sphingolipid transporter activity	4/1007	18/18367	0.0148275998588256	0.142677823131353	ATP10D/ABCA1/PLEKHA8/ABCB1	4
GO:0015026	coreceptor activity	7/1007	48/18367	0.015030254897912	0.143166973421525	NRP1/ITGAV/ITGB1/LRP5/LRP1/TGFBR3/RYK	7
GO:0015175	neutral amino acid transmembrane transporter activity	6/1007	38/18367	0.0164093906294771	0.153208468946504	SLC38A9/SLC43A2/SLC38A1/SLC1A5/SLC38A2/SERINC3	6
GO:0140303	intramembrane lipid transporter activity	6/1007	38/18367	0.0164093906294771	0.153208468946504	ATP10D/ANO6/ABCA1/TMEM30B/ABCB1/TMEM30A	6
GO:0001968	fibronectin binding	5/1007	28/18367	0.0168202523051947	0.155504881605869	CTSL/FBLN1/ITGAV/CCDC80/ITGB1	5
GO:0015370	solute:sodium symporter activity	9/1007	73/18367	0.0179703956635851	0.16452507874525	SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC13A3/SLC1A3/SLC5A6/SLC20A2/SLC38A2	9
GO:0008094	ATP-dependent activity, acting on DNA	12/1007	111/18367	0.0185393866021225	0.165642401758325	SMARCA2/SMARCA1/RAD50/ATRX/BPTF/SMARCA5/TOP2B/NAV2/DHX36/DDX1/CDK7/CHD6	12
GO:0019787	ubiquitin-like protein transferase activity	36/1007	458/18367	0.0192245654920619	0.165642401758325	RNF43/ZNF451/LMO7/ZNRF3/RNF128/CBX4/TRIM33/MDM2/UBE2H/NHLRC3/RNF217/HECTD1/TRIM44/HUWE1/KLHL42/SIAH1/UBE4B/UFL1/SIAH2/BIRC6/MYCBP2/NEDD4/TRIM24/WWP1/SEL1L/HERC4/RANBP2/MYLIP/AKTIP/UBR5/UBR4/TTC3/KIAA1586/CUL5/HERC2/UBE2G2	36
GO:1990841	promoter-specific chromatin binding	8/1007	62/18367	0.0194361857807425	0.165642401758325	DNMT1/FOXO4/ISL1/ZNF609/NIPBL/POLR2A/HDAC2/HNRNPU	8
GO:0002162	dystroglycan binding	3/1007	11/18367	0.0194650256191707	0.165642401758325	DAG1/DMD/PLEC	3
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	3/1007	11/18367	0.0194650256191707	0.165642401758325	P4HB/PCYOX1/SUMF1	3
GO:0022889	serine transmembrane transporter activity	3/1007	11/18367	0.0194650256191707	0.165642401758325	SLC1A5/SLC38A2/SERINC3	3
GO:0035197	siRNA binding	3/1007	11/18367	0.0194650256191707	0.165642401758325	FMR1/DICER1/AGO2	3
GO:0003725	double-stranded RNA binding	9/1007	74/18367	0.0194976740139704	0.165642401758325	TFRC/CLTC/HSPD1/TLR3/DICER1/DHX36/DDX1/AGO2/HNRNPU	9
GO:1901681	sulfur compound binding	23/1007	265/18367	0.0200915504712232	0.16916367941396	FBN1/APP/NRP2/ADGRG1/APLP2/NRP1/BMP7/CCDC80/LRPAP1/ADAMTS1/LRP1/PCOLCE2/TGFBR3/HADHA/SMOC1/FSTL1/ACADVL/ECI2/ACBD6/FGFR2/NAV2/ACBD3/SOD3	23
GO:0016860	intramolecular oxidoreductase activity	7/1007	51/18367	0.0205301609430676	0.170624242759931	P4HB/PDIA3/PDIA6/PDIA4/ECI2/RPIA/PDIA5	7
GO:0004177	aminopeptidase activity	6/1007	40/18367	0.0208078344829184	0.170624242759931	DPP4/ENPEP/CTSV/MMP15/NPEPPS/MMP14	6
GO:0017080	sodium channel regulator activity	6/1007	40/18367	0.0208078344829184	0.170624242759931	FXYD3/ATP2B4/PRSS8/NEDD4/PKP2/GPD1L	6
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4/1007	20/18367	0.0215267417179666	0.173501858461902	CDS1/AASDHPPT/GNPTAB/PTDSS1	4
GO:0030506	ankyrin binding	4/1007	20/18367	0.0215267417179666	0.173501858461902	CDH1/NRCAM/SPTBN1/PLEC	4
GO:0008276	protein methyltransferase activity	10/1007	88/18367	0.0220413429151944	0.176143952279901	ASH1L/DNMT3A/SMYD2/SETD2/SUZ12/NSD1/KMT2C/PRDM2/PCMTD1/PCMTD2	10
GO:0017147	Wnt-protein binding	5/1007	30/18367	0.0222948609528593	0.176672721668457	WLS/LRP5/RYK/FZD6/FZD5	5
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	3/1007	12/18367	0.024913879233909	0.192487246156028	BRD4/CDK6/CDK7	3
GO:0008429	phosphatidylethanolamine binding	3/1007	12/18367	0.024913879233909	0.192487246156028	NF1/ESYT2/PEBP1	3
GO:0031543	peptidyl-proline dioxygenase activity	3/1007	12/18367	0.024913879233909	0.192487246156028	P4HB/P3H2/P3H1	3
GO:0008194	UDP-glycosyltransferase activity	14/1007	143/18367	0.0254071582237618	0.192487246156028	GALNT11/EXTL2/CHPF/GCNT2/GXYLT1/HEXB/B4GALT1/B3GNT3/HEXA/B3GNT2/GCNT4/EXT2/GALNT18/B4GAT1	14
GO:0140318	protein transporter activity	5/1007	31/18367	0.0254182953728642	0.192487246156028	LRP2/IGF1R/ABCA1/SEC63/TOMM20	5
GO:0008238	exopeptidase activity	11/1007	103/18367	0.0255152765318171	0.192487246156028	MME/DPP4/TFRC/ENPEP/CTSV/GGH/CPD/MMP15/NAALADL2/NPEPPS/MMP14	11
GO:0044389	ubiquitin-like protein ligase binding	26/1007	316/18367	0.0258100449212979	0.193165653657015	EGFR/HSPA5/CALR/HSPD1/MDM2/ERBB3/PSMD1/USP25/LRPPRC/GABARAPL1/RTN4/TRIOBP/HSP90AA1/VCP/FZD6/FZD5/BCL2/ABCB1/HSPA1B/GSK3B/POLR2A/ATF6/CUL5/HERC2/HSPA9/UQCRC1	26
GO:0016922	nuclear receptor binding	14/1007	144/18367	0.0267803385236655	0.198849285258398	NCOA3/PARP1/CALR/FUS/TACC2/ISL1/ACTN4/NSD1/PPARG/TRIM24/CTNNB1/TCF7L2/BRD8/TMF1	14
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	7/1007	54/18367	0.0272943692391959	0.201082735879388	ASPH/P4HB/KDM5B/TET2/P3H2/KDM4B/P3H1	7
GO:0042393	histone binding	21/1007	244/18367	0.0276163323365749	0.201877530181319	MORC4/CTSL/SMARCA2/BRD4/TBL1X/CBX4/KDM5B/ATRX/RBBP7/BPTF/MPHOSPH8/SMARCA5/FMR1/SUZ12/BRD7/TRIM24/IPO7/KMT2C/BAZ1B/SMARCC1/SBNO1	21
GO:0140658	ATP-dependent chromatin remodeler activity	5/1007	32/18367	0.0288084890807034	0.208972347716179	SMARCA2/SMARCA1/ATRX/SMARCA5/CHD6	5
GO:0005080	protein kinase C binding	7/1007	55/18367	0.0298493881123841	0.214870022824261	DSP/ITGAV/PARD6B/TOP2B/PKP2/PRKCSH/SRSF2	7
GO:0004859	phospholipase inhibitor activity	3/1007	13/18367	0.0310948474106015	0.22046948201652	ANXA5/ANXA3/ANXA2	3
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	3/1007	13/18367	0.0310948474106015	0.22046948201652	DUSP9/DUSP14/DUSP5	3
GO:0005154	epidermal growth factor receptor binding	5/1007	33/18367	0.0324712560003637	0.225769832118788	EFEMP1/VAV3/YES1/ATXN2/SNX4	5
GO:0030374	nuclear receptor coactivator activity	7/1007	56/18367	0.0325606544731232	0.225769832118788	NCOA3/DCAF6/CCAR1/ACTN4/USP22/BRD8/TMF1	7
GO:0042054	histone methyltransferase activity	7/1007	56/18367	0.0325606544731232	0.225769832118788	ASH1L/SMYD2/SETD2/SUZ12/NSD1/KMT2C/PRDM2	7
GO:0005158	insulin receptor binding	4/1007	23/18367	0.0345697528370966	0.236226644386827	IGF1R/SORBS1/PTPN1/SNX4	4
GO:0140103	catalytic activity, acting on a glycoprotein	4/1007	23/18367	0.0345697528370966	0.236226644386827	C1GALT1/FUT8/B3GNT3/GCNT4	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	7/1007	57/18367	0.0354314370522968	0.240372986620978	P4HB/PDIA3/PDIA6/PCYOX1/PDIA4/PDIA5/SUMF1	7
GO:0016831	carboxy-lyase activity	5/1007	34/18367	0.0364114415916736	0.243517655467718	PISD/UXS1/PDXDC1/AZIN1/ECHDC1	5
GO:0035198	miRNA binding	5/1007	34/18367	0.0364114415916736	0.243517655467718	KCNQ1OT1/PUM1/FMR1/AGO2/HNRNPA2B1	5
GO:0003697	single-stranded DNA binding	12/1007	123/18367	0.0375197905700012	0.249163116250078	SMARCA1/HSPD1/RAD50/RAD23B/LRPPRC/PURA/DHX36/PURB/SSBP3/XPC/HNRNPU/HNRNPA2B1	12
GO:0032977	membrane insertase activity	3/1007	14/18367	0.0380000420783627	0.250587690069203	EMC1/EMC10/EMC7	3
GO:0061980	regulatory RNA binding	6/1007	46/18367	0.0385802415738463	0.25264699863984	KCNQ1OT1/PUM1/FMR1/DICER1/AGO2/HNRNPA2B1	6
GO:0050431	transforming growth factor beta binding	4/1007	24/18367	0.0397410165203637	0.256255997416609	ITGAV/TGFBR3/TGFBR1/LTBP3	4
GO:0070840	dynein complex binding	4/1007	24/18367	0.0397410165203637	0.256255997416609	ATMIN/TPR/FMR1/GPSM2	4
GO:0048029	monosaccharide binding	8/1007	71/18367	0.0399465870840313	0.256255997416609	COLEC12/LMAN1/MANBA/UGP2/BSG/RPIA/P3H2/P3H1	8
GO:0004867	serine-type endopeptidase inhibitor activity	10/1007	98/18367	0.0422015327597352	0.267998968339448	ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/SERPINH1/PEBP1/ANXA2	10
GO:0061659	ubiquitin-like protein ligase activity	25/1007	316/18367	0.0423455421872511	0.267998968339448	RNF43/ZNF451/ZNRF3/RNF128/CBX4/MDM2/NHLRC3/RNF217/HECTD1/TRIM44/HUWE1/SIAH1/UBE4B/UFL1/SIAH2/MYCBP2/NEDD4/TRIM24/WWP1/RANBP2/MYLIP/UBR5/UBR4/KIAA1586/HERC2	25
GO:0030276	clathrin binding	8/1007	72/18367	0.0428734077061298	0.269530823112536	LRP1/CLTC/SYT7/STON1/EPN2/AP2A2/CLINT1/NSG1	8
GO:0140297	DNA-binding transcription factor binding	30/1007	394/18367	0.0435750821163134	0.269603536304676	NCOA3/TLE4/PARP1/CALR/YAP1/FOXO4/FUS/GTF2I/TACC2/ISL1/KLF5/GABARAPL1/ACTN4/NSD1/PPARG/PURA/MAPK14/TRIM24/CTNNB1/TCERG1/BHLHE41/TCF7L2/BCL2/RBFOX2/GSK3B/PURB/BRD8/TMF1/HDAC2/NFE2L2	30
GO:0008242	omega peptidase activity	12/1007	126/18367	0.0438659420336418	0.269603536304676	GGH/USP25/USP27X/USP47/USP9X/USP10/USP48/USP34/USP22/OTUD4/OTUD7B/USP14	12
GO:0004029	aldehyde dehydrogenase (NAD+) activity	3/1007	15/18367	0.0456153961170933	0.269603536304676	ALDH7A1/ADH5/ALDH1A3	3
GO:0004467	long-chain fatty acid-CoA ligase activity	3/1007	15/18367	0.0456153961170933	0.269603536304676	SLC27A2/ACSF2/ACSL3	3
GO:0004559	alpha-mannosidase activity	3/1007	15/18367	0.0456153961170933	0.269603536304676	MAN1A2/EDEM3/MAN2A1	3
GO:0005041	low-density lipoprotein particle receptor activity	3/1007	15/18367	0.0456153961170933	0.269603536304676	LRP2/OLR1/LRP1	3
GO:0005545	1-phosphatidylinositol binding	3/1007	15/18367	0.0456153961170933	0.269603536304676	EEA1/SCIN/ZFYVE16	3
GO:0015929	hexosaminidase activity	3/1007	15/18367	0.0456153961170933	0.269603536304676	HEXB/HEXA/GM2A	3
GO:0050998	nitric-oxide synthase binding	3/1007	15/18367	0.0456153961170933	0.269603536304676	SLC6A4/ATP2B4/DMD	3
GO:0004843	thiol-dependent deubiquitinase	11/1007	113/18367	0.0457439722256079	0.269603536304676	USP25/USP27X/USP47/USP9X/USP10/USP48/USP34/USP22/OTUD4/OTUD7B/USP14	11
GO:0042826	histone deacetylase binding	12/1007	127/18367	0.0461372137420519	0.270232251917733	PARP1/GLI3/CCND1/SFPQ/TOP2B/HSP90AA1/PKN2/DHX36/BHLHE41/HSPA1B/NIPBL/HDAC2	12
GO:0101005	deubiquitinase activity	11/1007	114/18367	0.0482370581894192	0.280787320201372	USP25/USP27X/USP47/USP9X/USP10/USP48/USP34/USP22/OTUD4/OTUD7B/USP14	11
GO:0017022	myosin binding	8/1007	74/18367	0.0491433295357591	0.28194230229724	FUS/DMD/CALD1/RAB6A/TRIOBP/TRPM7/VEZT/ARFGEF1	8
GO:0005539	glycosaminoglycan binding	19/1007	230/18367	0.0493212661072105	0.28194230229724	FBN1/APP/NRP2/ADGRG1/APLP2/EXTL2/NRP1/BMP7/CCDC80/LRPAP1/ADAMTS1/PCOLCE2/TGFBR3/SMOC1/FSTL1/FGFR2/NAV2/GNS/SOD3	19
GO:0015035	protein-disulfide reductase activity	5/1007	37/18367	0.0499303971194477	0.28194230229724	P4HB/PDIA3/PDIA6/PDIA4/PDIA5	5
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	5/1007	37/18367	0.0499303971194477	0.28194230229724	ALDH7A1/ADH5/ALDH18A1/ALDH1A3/FAR1	5
GO:0046915	transition metal ion transmembrane transporter activity	5/1007	37/18367	0.0499303971194477	0.28194230229724	SLC39A10/SLC40A1/SLC39A7/SLC39A1/TMEM165	5
GO:0042974	retinoic acid receptor binding	4/1007	26/18367	0.051329401813923	0.288018159581787	FUS/ACTN4/NSD1/PPARG	4
GO:0060090	molecular adaptor activity	28/1007	369/18367	0.0516172523534698	0.288018159581787	SYNE2/COL14A1/AKAP9/DLG5/DDB1/PDE4DIP/DLG1/ANK3/MPP7/FRMD4A/CUX1/RAD50/OBSL1/SPAG9/SLC9A1/STON1/HOMER1/EIF4G1/EPB41L3/NCSTN/SORBS1/ICE1/PKP2/SUN1/EPS8/AP2A2/OTUD4/SHANK2	28
GO:0017124	SH3 domain binding	12/1007	130/18367	0.0534333176204937	0.288909628478086	LRP2/GJA1/FUT8/WASF2/CD2AP/UVRAG/SH3BGRL2/ERRFI1/DOCK1/CCDC6/SHANK2/QKI	12
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	3/1007	16/18367	0.0539216273723681	0.288909628478086	ALDH7A1/ADH5/ALDH1A3	3
GO:0005283	amino acid:sodium symporter activity	3/1007	16/18367	0.0539216273723681	0.288909628478086	SLC38A1/SLC1A3/SLC38A2	3
GO:0005402	carbohydrate:cation symporter activity	3/1007	16/18367	0.0539216273723681	0.288909628478086	SLC5A3/SLC17A5/SLC45A4	3
GO:0032183	SUMO binding	3/1007	16/18367	0.0539216273723681	0.288909628478086	CBX4/USP25/HERC2	3
GO:0070403	NAD+ binding	3/1007	16/18367	0.0539216273723681	0.288909628478086	HADHA/UXS1/ALDH1A3	3
GO:1990380	Lys48-specific deubiquitinase activity	3/1007	16/18367	0.0539216273723681	0.288909628478086	USP27X/USP9X/OTUD7B	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	6/1007	50/18367	0.0545721048404085	0.290195547717278	SLC35B4/SLC19A1/SLC25A36/SLC35D1/SLC29A3/SLC29A1	6
GO:0051117	ATPase binding	9/1007	89/18367	0.0547771023262731	0.290195547717278	EGFR/TOR1AIP2/USP25/ABCA1/UBE4B/NCSTN/EZR/TMEM106B/RDX	9
GO:0005200	structural constituent of cytoskeleton	10/1007	103/18367	0.0559235557638974	0.29461403958299	DSP/ANK3/DMD/CD2AP/EPB41L3/SPTAN1/SPTBN1/PLEC/CCDC6/ADD3	10
GO:0004190	aspartic-type endopeptidase activity	4/1007	27/18367	0.0577427311478888	0.297548609139121	SPPL2A/NCSTN/SPPL2B/SPPL3	4
GO:0016405	CoA-ligase activity	4/1007	27/18367	0.0577427311478888	0.297548609139121	ACSS1/SLC27A2/ACSF2/ACSL3	4
GO:0048027	mRNA 5'-UTR binding	4/1007	27/18367	0.0577427311478888	0.297548609139121	MYH10/IGF2BP3/FMR1/DHX36	4
GO:0070006	metalloaminopeptidase activity	4/1007	27/18367	0.0577427311478888	0.297548609139121	ENPEP/MMP15/NPEPPS/MMP14	4
GO:0016836	hydro-lyase activity	7/1007	64/18367	0.0602072233091822	0.307751783417137	HACD3/HADHA/ECHDC2/ECHDC1/ACO1/FASN/ALAD	7
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	5/1007	39/18367	0.0603754824307215	0.307751783417137	IQGAP2/FERMT2/CYTH3/PARD3/ZFYVE16	5
GO:0008381	mechanosensitive ion channel activity	3/1007	17/18367	0.0628951013650818	0.310523982132315	TMEM150C/TMC5/TMEM63A	3
GO:0015174	basic amino acid transmembrane transporter activity	3/1007	17/18367	0.0628951013650818	0.310523982132315	SLC38A9/SLC7A6/SLC7A2	3
GO:0030275	LRR domain binding	3/1007	17/18367	0.0628951013650818	0.310523982132315	ERC1/PAWR/KRAS	3
GO:0046965	retinoid X receptor binding	3/1007	17/18367	0.0628951013650818	0.310523982132315	FUS/NSD1/PPARG	3
GO:0048531	beta-1,3-galactosyltransferase activity	3/1007	17/18367	0.0628951013650818	0.310523982132315	C1GALT1/B3GNT3/B3GNT2	3
GO:0050780	dopamine receptor binding	3/1007	17/18367	0.0628951013650818	0.310523982132315	GNA12/VPS35/GNAS	3
GO:0031593	polyubiquitin modification-dependent protein binding	6/1007	52/18367	0.0638682951406758	0.310627780938278	AGL/RAD23B/VCP/PRPF8/OTUD7B/TAB3	6
GO:1901682	sulfur compound transmembrane transporter activity	6/1007	52/18367	0.0638682951406758	0.310627780938278	SLC26A2/SLC13A4/GJA1/SLC13A3/SLC19A3/SLC5A6	6
GO:0008187	poly-pyrimidine tract binding	4/1007	28/18367	0.0645631442883377	0.310627780938278	MSI2/FMR1/RBMS3/HNRNPU	4
GO:0070001	aspartic-type peptidase activity	4/1007	28/18367	0.0645631442883377	0.310627780938278	SPPL2A/NCSTN/SPPL2B/SPPL3	4
GO:0070325	lipoprotein particle receptor binding	4/1007	28/18367	0.0645631442883377	0.310627780938278	HSP90B1/LRPAP1/LRP1/CLTC	4
GO:0044183	protein folding chaperone	5/1007	40/18367	0.0660280035661221	0.316062981537325	HSPA5/CCDC47/CALR/HSPA1B/HSPA9	5
GO:0002020	protease binding	12/1007	135/18367	0.0672533324212295	0.320302487238482	ADAMTSL4/ITGAV/DPP4/ITGB1/LRP1/CLTC/DVL3/VCP/BCL2/GSK3B/FLOT2/ANXA2	12
GO:1901505	carbohydrate derivative transmembrane transporter activity	6/1007	53/18367	0.0688439846235417	0.326230540201004	SLC35B4/SLC19A1/SLC35D1/SLC17A5/SLC29A3/SLC29A1	6
GO:0035091	phosphatidylinositol binding	21/1007	271/18367	0.0699575528090871	0.329849861494845	IQGAP2/EEA1/SCIN/SYT7/EXOC1/PLEKHA8/SLC9A1/FERMT2/ARHGAP32/CYTH3/SNX13/PARD3/SH3YL1/ESYT2/PLEKHA5/SNX14/ZFYVE16/TTPA/SNX4/PHLDA2/ANXA2	21
GO:0030331	estrogen receptor binding	5/1007	41/18367	0.0719652017904063	0.331920443550252	PARP1/FUS/ISL1/NSD1/CTNNB1	5
GO:0030228	lipoprotein particle receptor activity	3/1007	18/18367	0.072508601666333	0.331920443550252	LRP2/OLR1/LRP1	3
GO:0033549	MAP kinase phosphatase activity	3/1007	18/18367	0.072508601666333	0.331920443550252	DUSP9/DUSP14/DUSP5	3
GO:0055102	lipase inhibitor activity	3/1007	18/18367	0.072508601666333	0.331920443550252	ANXA5/ANXA3/ANXA2	3
GO:0098641	cadherin binding involved in cell-cell adhesion	3/1007	18/18367	0.072508601666333	0.331920443550252	TRIM29/ANXA2/KRT18	3
GO:0140597	protein carrier activity	3/1007	18/18367	0.072508601666333	0.331920443550252	EMC1/EMC10/EMC7	3
GO:0004175	endopeptidase activity	31/1007	430/18367	0.0730185857046741	0.332640223765738	MME/CTSL/ADAMTS6/DPP4/PDIA3/ADAMTS1/SPPL2A/CTSV/USP25/USP47/PRSS8/USP9X/USP10/MBTPS1/PRSS12/USP48/ADAMTS19/MMP15/TMEM59/NCSTN/AFG3L2/USP34/NRDC/MMP14/SPPL2B/ADGRG6/ST14/PCSK7/SPPL3/YME1L1/USP14	31
GO:0015036	disulfide oxidoreductase activity	5/1007	42/18367	0.0781845399977348	0.351866835969472	P4HB/PDIA3/PDIA6/PDIA4/PDIA5	5
GO:0004842	ubiquitin-protein transferase activity	31/1007	433/18367	0.0782922314066624	0.351866835969472	RNF43/LMO7/ZNRF3/RNF128/TRIM33/MDM2/UBE2H/NHLRC3/RNF217/HECTD1/TRIM44/HUWE1/KLHL42/SIAH1/UBE4B/SIAH2/BIRC6/MYCBP2/NEDD4/TRIM24/WWP1/SEL1L/HERC4/MYLIP/AKTIP/UBR5/UBR4/TTC3/CUL5/HERC2/UBE2G2	31
GO:0005310	dicarboxylic acid transmembrane transporter activity	4/1007	30/18367	0.0793979685895794	0.351866835969472	SLC26A2/SLC19A1/SLC13A3/SLC1A5	4
GO:0005343	organic acid:sodium symporter activity	4/1007	30/18367	0.0793979685895794	0.351866835969472	SLC38A1/SLC13A3/SLC1A3/SLC38A2	4
GO:0046966	thyroid hormone receptor binding	4/1007	30/18367	0.0793979685895794	0.351866835969472	NCOA3/FUS/NSD1/BRD8	4
GO:0005543	phospholipid binding	33/1007	466/18367	0.0797273474285998	0.351866835969472	MME/NF1/IQGAP2/MYOF/EEA1/SCIN/ABCA1/SYT7/EXOC1/PLEKHA8/SLC9A1/FERMT2/ARHGAP32/EPN2/PRKCI/CYTH3/SNX13/PARD3/SH3YL1/ANXA5/ESYT2/SPTBN1/PLEKHA5/SNX14/OPHN1/ZFYVE16/TTPA/SNX4/CLINT1/ANXA3/PHLDA2/PEBP1/ANXA2	33
GO:0019955	cytokine binding	12/1007	139/18367	0.0798510104957233	0.351866835969472	NRP2/NRP1/ITGAV/CSF3R/ITGB1/CSF2RA/PRLR/TGFBR3/IL6ST/TGFBR1/LTBP3/LIFR	12
GO:0019783	ubiquitin-like protein-specific protease activity	11/1007	125/18367	0.0818311419747361	0.358915194800819	USP25/USP27X/USP47/USP9X/USP10/USP48/USP34/USP22/OTUD4/OTUD7B/USP14	11
GO:0018024	histone-lysine N-methyltransferase activity	5/1007	43/18367	0.0846826788964972	0.369702621293504	ASH1L/SMYD2/SETD2/NSD1/KMT2C	5
GO:0051287	NAD binding	6/1007	56/18367	0.0850750398949481	0.369703975211687	PARP1/IDH1/HADHA/UXS1/ALDH1A3/GPD1L	6
GO:0004386	helicase activity	13/1007	156/18367	0.0872530188033854	0.372911514267258	SMARCA2/SMARCA1/RAD50/ATRX/DDX17/SMARCA5/DICER1/HELZ/NAV2/DHX36/DDX1/SNRNP200/CHD6	13
GO:0000146	microfilament motor activity	4/1007	31/18367	0.0873949572142778	0.372911514267258	MYH10/MYO7A/MYO1C/MYO6	4
GO:0016878	acid-thiol ligase activity	4/1007	31/18367	0.0873949572142778	0.372911514267258	ACSS1/SLC27A2/ACSF2/ACSL3	4
GO:0042910	xenobiotic transmembrane transporter activity	4/1007	31/18367	0.0873949572142778	0.372911514267258	SLC2A1/SLC19A1/SLC22A5/ABCB1	4
GO:0005201	extracellular matrix structural constituent	14/1007	172/18367	0.090558225572322	0.383300226640242	FBN2/FBN1/EFEMP1/LAMB1/COL14A1/LAMC1/TINAGL1/FBLN1/LAMA5/VWA1/COL21A1/FRAS1/COL4A2/COL5A2	14
GO:0005548	phospholipid transporter activity	6/1007	57/18367	0.0909154637587893	0.383300226640242	ANO6/ABCA1/PLEKHA8/TMEM30B/ABCB1/TMEM30A	6
GO:0030674	protein-macromolecule adaptor activity	22/1007	296/18367	0.0914387884662655	0.383300226640242	SYNE2/COL14A1/DLG5/DDB1/ANK3/MPP7/FRMD4A/CUX1/RAD50/OBSL1/SPAG9/SLC9A1/STON1/HOMER1/EPB41L3/NCSTN/SORBS1/ICE1/SUN1/EPS8/AP2A2/SHANK2	22
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	5/1007	44/18367	0.0914555153701531	0.383300226640242	ALDH7A1/ADH5/ALDH18A1/ALDH1A3/FAR1	5
GO:0106310	protein serine kinase activity	26/1007	360/18367	0.0925569913131756	0.385159689954676	NRK/CDK6/AAK1/SLK/PRKDC/CAMK2G/EIF2AK1/MAP3K4/CDKL5/RPS6KA5/LIMK2/STK26/TLK1/PRKCI/LATS2/PKN2/EIF2AK4/TRPM7/MAPK14/PLK2/STK17A/CDK7/GSK3B/CDC42BPB/PRPF4B/MAP3K13	26
GO:0016500	protein-hormone receptor activity	3/1007	20/18367	0.0935329469773285	0.385159689954676	LGR5/LGR4/IGF1R	3
GO:0031683	G-protein beta/gamma-subunit complex binding	3/1007	20/18367	0.0935329469773285	0.385159689954676	GNA12/GNAI1/GNAS	3
GO:0031690	adrenergic receptor binding	3/1007	20/18367	0.0935329469773285	0.385159689954676	ADRB1/NEDD4/GNAS	3
GO:0008378	galactosyltransferase activity	4/1007	32/18367	0.0957644526619314	0.392634255913919	C1GALT1/B4GALT1/B3GNT3/B3GNT2	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	6/1007	58/18367	0.0969674720241089	0.39584556761357	SLC27A2/SLC16A12/SLC16A4/SLC16A1/SLC16A2/SLC5A6	6
GO:0042562	hormone binding	8/1007	86/18367	0.0988851389846537	0.396420491992381	EGFR/LRP2/SLC40A1/IGF1R/PRLR/CALR/NRDC/ALDH1A3	8
GO:0008235	metalloexopeptidase activity	7/1007	72/18367	0.0989473283606968	0.396420491992381	TFRC/ENPEP/CPD/MMP15/NAALADL2/NPEPPS/MMP14	7
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	22/1007	299/18367	0.0989989011388289	0.396420491992381	NCOA3/PARP1/CALR/FUS/GTF2I/TACC2/ISL1/GABARAPL1/ACTN4/NSD1/PPARG/MAPK14/TRIM24/CTNNB1/TCERG1/BHLHE41/TCF7L2/GSK3B/BRD8/TMF1/HDAC2/NFE2L2	22
GO:0008234	cysteine-type peptidase activity	15/1007	190/18367	0.0997155837768201	0.396420491992381	CTSL/PDIA3/CTSV/GGH/USP25/USP27X/USP47/USP9X/USP10/USP48/USP34/USP22/OTUD4/OTUD7B/USP14	15
GO:0008172	S-methyltransferase activity	2/1007	10/18367	0.100891747696894	0.396420491992381	MTR/DNMT3A	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/1007	10/18367	0.100891747696894	0.396420491992381	DUSP9/DUSP5	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/1007	10/18367	0.100891747696894	0.396420491992381	SLC35B4/SLC35D1	2
GO:0045294	alpha-catenin binding	2/1007	10/18367	0.100891747696894	0.396420491992381	CTNNB1/PKP2	2
GO:0051880	G-quadruplex DNA binding	2/1007	10/18367	0.100891747696894	0.396420491992381	RAD50/DHX36	2
GO:0016247	channel regulator activity	12/1007	145/18367	0.101370586380323	0.39664922388649	RASA1/AKAP9/DLG1/FXYD3/SLC5A3/ATP2B4/PRSS8/TSPAN13/NEDD4/PKP2/BCL2/GPD1L	12
GO:0035064	methylated histone binding	7/1007	73/18367	0.104569488086442	0.398787287094709	MORC4/CBX4/ATRX/BPTF/MPHOSPH8/FMR1/SUZ12	7
GO:0140034	methylation-dependent protein binding	7/1007	73/18367	0.104569488086442	0.398787287094709	MORC4/CBX4/ATRX/BPTF/MPHOSPH8/FMR1/SUZ12	7
GO:0005385	zinc ion transmembrane transporter activity	3/1007	21/18367	0.104877250476657	0.398787287094709	SLC39A10/SLC39A7/SLC39A1	3
GO:0015662	P-type ion transporter activity	3/1007	21/18367	0.104877250476657	0.398787287094709	ATP2B1/ATP2B4/ATP2A2	3
GO:0070577	lysine-acetylated histone binding	3/1007	21/18367	0.104877250476657	0.398787287094709	BRD4/BRD7/TRIM24	3
GO:0140033	acetylation-dependent protein binding	3/1007	21/18367	0.104877250476657	0.398787287094709	BRD4/BRD7/TRIM24	3
GO:0140358	P-type transmembrane transporter activity	3/1007	21/18367	0.104877250476657	0.398787287094709	ATP2B1/ATP2B4/ATP2A2	3
GO:0033218	amide binding	28/1007	400/18367	0.110586175380915	0.418806278651415	MME/ENPEP/LRPAP1/SLC40A1/IGF1R/LRP1/PRLR/CALR/SLC19A1/NKTR/CTSV/HADHA/FOLR1/TNPO1/ACADVL/PLEKHA8/ECI2/DHCR24/ACBD6/CLSTN1/NPEPPS/PPARG/FZD5/ACBD3/FASN/PPIB/KDELR1/TOMM20	28
GO:0016887	ATP hydrolysis activity	20/1007	272/18367	0.112029002600841	0.422573397810374	ATP2B1/HSPA5/ATP10D/RHOBTB3/ATP13A3/ATP2B4/HSPD1/ATRX/DDX17/SMARCA5/HSP90AA1/VCP/NAV2/DHX36/DDX1/SNRNP200/ATP2A2/HSPA1B/CHD6/HSPA9	20
GO:0019829	ATPase-coupled cation transmembrane transporter activity	5/1007	47/18367	0.113370582423472	0.423368970494493	ATP2B1/ATP13A3/ATP2B4/ATP6V1C2/ATP2A2	5
GO:0008376	acetylgalactosaminyltransferase activity	4/1007	34/18367	0.113572296374717	0.423368970494493	GALNT11/EXTL2/CHPF/GALNT18	4
GO:0004674	protein serine/threonine kinase activity	27/1007	386/18367	0.116131502575952	0.423368970494493	EGFR/NRK/BRD4/CDK6/AAK1/SLK/TGFBR3/PRKDC/CAMK2G/EIF2AK1/MAP3K4/CDKL5/RPS6KA5/LIMK2/TLK1/PRKCI/LATS2/TGFBR1/PKN2/EIF2AK4/MAPK14/PLK2/STK17A/CDK7/GSK3B/CDC42BPB/MAP3K13	27
GO:0005416	amino acid:cation symporter activity	3/1007	22/18367	0.116729514664441	0.423368970494493	SLC38A1/SLC1A3/SLC38A2	3
GO:0005537	mannose binding	3/1007	22/18367	0.116729514664441	0.423368970494493	LMAN1/MANBA/BSG	3
GO:0008093	cytoskeletal anchor activity	3/1007	22/18367	0.116729514664441	0.423368970494493	ANK3/OBSL1/EPB41L3	3
GO:0008320	protein transmembrane transporter activity	3/1007	22/18367	0.116729514664441	0.423368970494493	ABCA1/SEC63/TOMM20	3
GO:0015296	anion:cation symporter activity	3/1007	22/18367	0.116729514664441	0.423368970494493	SLC6A4/SLC13A4/SLC12A9	3
GO:0015645	fatty acid ligase activity	3/1007	22/18367	0.116729514664441	0.423368970494493	SLC27A2/ACSF2/ACSL3	3
GO:0070034	telomerase RNA binding	3/1007	22/18367	0.116729514664441	0.423368970494493	DCP2/DHX36/HNRNPU	3
GO:0004197	cysteine-type endopeptidase activity	10/1007	119/18367	0.117920054689871	0.423412604000893	CTSL/PDIA3/CTSV/USP25/USP47/USP9X/USP10/USP48/USP34/USP14	10
GO:0008503	benzodiazepine receptor activity	2/1007	11/18367	0.118986574825277	0.423412604000893	GABRE/GABRA4	2
GO:0035673	oligopeptide transmembrane transporter activity	2/1007	11/18367	0.118986574825277	0.423412604000893	GJA1/SLC13A3	2
GO:0043522	leucine zipper domain binding	2/1007	11/18367	0.118986574825277	0.423412604000893	ERC1/PAWR	2
GO:0047676	arachidonate-CoA ligase activity	2/1007	11/18367	0.118986574825277	0.423412604000893	SLC27A2/ACSL3	2
GO:0015085	calcium ion transmembrane transporter activity	11/1007	135/18367	0.122524164129588	0.434358617013567	ATP2B1/ITGAV/ATP2B4/MCOLN3/TRPV6/P2RX4/TRPM7/TMEM165/ATP2A2/CUL5/ANXA2	11
GO:0042887	amide transmembrane transporter activity	4/1007	35/18367	0.122983828995358	0.434358617013567	GJA1/SLC19A1/SLC13A3/SLC5A6	4
GO:0050750	low-density lipoprotein particle receptor binding	3/1007	23/18367	0.129053478938543	0.449745953184373	HSP90B1/LRPAP1/CLTC	3
GO:0070412	R-SMAD binding	3/1007	23/18367	0.129053478938543	0.449745953184373	PARP1/TRIM33/PPARG	3
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	3/1007	23/18367	0.129053478938543	0.449745953184373	PRPF8/OTUD7B/TAB3	3
GO:0016763	pentosyltransferase activity	5/1007	49/18367	0.129248306800599	0.449745953184373	PARP1/GXYLT1/QPRT/TNKS2/PNP	5
GO:0061134	peptidase regulator activity	17/1007	230/18367	0.130090043816808	0.451010703379596	ITIH5/APP/SPINT1/APLP2/CRIM1/FBLN1/SERPINF1/SPINT2/PCOLCE2/SERPINH1/BIRC6/VCP/CAST/GPC3/USP14/PEBP1/ANXA2	17
GO:0051213	dioxygenase activity	8/1007	92/18367	0.131549558533957	0.454400123434145	ASPH/P4HB/KDM5B/TET2/CDO1/P3H2/KDM4B/P3H1	8
GO:1902936	phosphatidylinositol bisphosphate binding	9/1007	107/18367	0.132664037500376	0.455090030273229	SCIN/SYT7/EXOC1/SLC9A1/PARD3/PLEKHA5/SNX14/TTPA/ANXA2	9
GO:0061631	ubiquitin conjugating enzyme activity	4/1007	36/18367	0.132714483907888	0.455090030273229	UBE2H/BIRC6/AKTIP/UBE2G2	4
GO:0000993	RNA polymerase II complex binding	5/1007	50/18367	0.137545662573954	0.457557924115382	NCOA3/BRD4/SMYD2/AGO2/HNRNPU	5
GO:0000340	RNA 7-methylguanosine cap binding	2/1007	12/18367	0.137801113943551	0.457557924115382	NCBP3/AGO2	2
GO:0003995	acyl-CoA dehydrogenase activity	2/1007	12/18367	0.137801113943551	0.457557924115382	ACADVL/TECR	2
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	2/1007	12/18367	0.137801113943551	0.457557924115382	CDKN1C/HEXIM1	2
GO:0005024	transforming growth factor beta-activated receptor activity	2/1007	12/18367	0.137801113943551	0.457557924115382	TGFBR3/TGFBR1	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/1007	12/18367	0.137801113943551	0.457557924115382	SLC35B4/SLC35D1	2
GO:0043047	single-stranded telomeric DNA binding	2/1007	12/18367	0.137801113943551	0.457557924115382	RAD50/HNRNPA2B1	2
GO:0061578	Lys63-specific deubiquitinase activity	2/1007	12/18367	0.137801113943551	0.457557924115382	USP27X/OTUD4	2
GO:0070410	co-SMAD binding	2/1007	12/18367	0.137801113943551	0.457557924115382	TRIM33/USP9X	2
GO:0005319	lipid transporter activity	12/1007	154/18367	0.139520647178225	0.461000788718924	SLC2A1/SLC27A2/ATP10D/ANO6/ABCA1/PLEKHA8/OSBPL9/TMEM30B/GM2A/ABCB1/TMEM30A/TTPA	12
GO:0099106	ion channel regulator activity	11/1007	139/18367	0.141475813821096	0.461000788718924	RASA1/AKAP9/DLG1/FXYD3/SLC5A3/ATP2B4/PRSS8/TSPAN13/NEDD4/PKP2/GPD1L	11
GO:0016835	carbon-oxygen lyase activity	7/1007	79/18367	0.14175869036606	0.461000788718924	HACD3/HADHA/ECHDC2/ECHDC1/ACO1/FASN/ALAD	7
GO:0008171	O-methyltransferase activity	3/1007	24/18367	0.14181240214114	0.461000788718924	CMTR1/PCMTD1/PCMTD2	3
GO:0043495	protein-membrane adaptor activity	3/1007	24/18367	0.14181240214114	0.461000788718924	SYNE2/EPB41L3/SUN1	3
GO:0005109	frizzled binding	4/1007	37/18367	0.142748918670123	0.461000788718924	RNF43/ZNRF3/DVL3/RYK	4
GO:0043531	ADP binding	4/1007	37/18367	0.142748918670123	0.461000788718924	MYH10/MYO7A/VCP/MYO6	4
GO:0071949	FAD binding	4/1007	37/18367	0.142748918670123	0.461000788718924	CYB5R1/DHCR24/MICAL3/SQLE	4
GO:0042626	ATPase-coupled transmembrane transporter activity	9/1007	109/18367	0.143755848605983	0.462668140735297	SLC26A2/ATP2B1/ATP13A3/ATP2B4/ABCA1/ATP6V1C2/ABCB1/ATP2A2/TOMM20	9
GO:0046873	metal ion transmembrane transporter activity	29/1007	430/18367	0.145969498164522	0.468194682888246	ATP2B1/ITGAV/TUSC3/SLC6A4/SLC13A4/SLC39A10/SLC40A1/SLC38A1/SLC5A3/ATP2B4/SLC13A3/KCNN4/MCOLN3/SLC39A7/SLC12A9/SLC9A1/TRPV6/SLC1A3/SLC5A6/P2RX4/SLC39A1/ZDHHC17/TRPM7/SLC20A2/TMEM165/SLC38A2/ATP2A2/CUL5/ANXA2	29
GO:0030414	peptidase inhibitor activity	14/1007	187/18367	0.147393494641954	0.471159543889363	ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/SERPINH1/BIRC6/CAST/GPC3/USP14/PEBP1/ANXA2	14
GO:0047485	protein N-terminus binding	9/1007	110/18367	0.149472584943911	0.47361573442277	NCOA3/PARP1/MDM2/SRRM2/MYO7A/SMARCC1/HSPA1B/NIPBL/RPS21	9
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4/1007	38/18367	0.153071222337583	0.47361573442277	RNF217/SIAH1/SIAH2/TCERG1	4
GO:0016830	carbon-carbon lyase activity	5/1007	52/18367	0.154816152305037	0.47361573442277	PISD/UXS1/PDXDC1/AZIN1/ECHDC1	5
GO:0005160	transforming growth factor beta receptor binding	3/1007	25/18367	0.154969383664525	0.47361573442277	TGFBR3/FERMT2/TGFBR1	3
GO:0005227	calcium activated cation channel activity	3/1007	25/18367	0.154969383664525	0.47361573442277	ANO6/KCNN4/TMEM63A	3
GO:0008266	poly(U) RNA binding	3/1007	25/18367	0.154969383664525	0.47361573442277	MSI2/FMR1/RBMS3	3
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/1007	25/18367	0.154969383664525	0.47361573442277	RBMS3/DHX36/TIA1	3
GO:0004222	metalloendopeptidase activity	9/1007	111/18367	0.155300683524522	0.47361573442277	MME/ADAMTS6/ADAMTS1/ADAMTS19/MMP15/AFG3L2/NRDC/MMP14/YME1L1	9
GO:0032182	ubiquitin-like protein binding	9/1007	111/18367	0.155300683524522	0.47361573442277	N4BP2/CBX4/MDM2/USP25/RAD23B/NEDD4/UBR5/HERC2/TAB3	9
GO:0035591	signaling adaptor activity	7/1007	81/18367	0.155403027593982	0.47361573442277	DLG5/MPP7/SPAG9/HOMER1/SORBS1/EPS8/SHANK2	7
GO:0005542	folic acid binding	2/1007	13/18367	0.157202253313178	0.47361573442277	SLC19A1/FOLR1	2
GO:0008035	high-density lipoprotein particle binding	2/1007	13/18367	0.157202253313178	0.47361573442277	HSPD1/ABCA1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/1007	13/18367	0.157202253313178	0.47361573442277	SLC26A2/SLC13A4	2
GO:0022851	GABA-gated chloride ion channel activity	2/1007	13/18367	0.157202253313178	0.47361573442277	GABRE/GABRA4	2
GO:0034236	protein kinase A catalytic subunit binding	2/1007	13/18367	0.157202253313178	0.47361573442277	EZR/GSK3B	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/1007	13/18367	0.157202253313178	0.47361573442277	UBE4B/UBR5	2
GO:0042301	phosphate ion binding	2/1007	13/18367	0.157202253313178	0.47361573442277	GNG12/PNP	2
GO:0051011	microtubule minus-end binding	2/1007	13/18367	0.157202253313178	0.47361573442277	MACF1/CAMSAP2	2
GO:0004721	phosphoprotein phosphatase activity	13/1007	174/18367	0.15994278642134	0.479449213433083	DLG1/PTPN14/CTDSPL/CAMK2G/DUSP9/PTP4A1/PTPN1/PTPRM/PPP4R1/DUSP14/PTPRA/PDP2/DUSP5	13
GO:0097110	scaffold protein binding	6/1007	67/18367	0.160376074839006	0.479449213433083	DSP/ATP2B4/DYNLL2/IL6ST/HSP90AA1/KRT18	6
GO:0008237	metallopeptidase activity	14/1007	190/18367	0.160663787322221	0.479449213433083	MME/ADAMTS6/TFRC/ENPEP/ADAMTS1/CPD/ADAMTS19/MMP15/AFG3L2/NAALADL2/NPEPPS/NRDC/MMP14/YME1L1	14
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	7/1007	82/18367	0.162443699249633	0.483231572215784	SCIN/SYT7/EXOC1/SLC9A1/PARD3/TTPA/ANXA2	7
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/1007	39/18367	0.163665021184081	0.485333694894932	UBE2H/BIRC6/AKTIP/UBE2G2	4
GO:0005544	calcium-dependent phospholipid binding	5/1007	54/18367	0.172928106835663	0.511194999203855	SYT7/ANXA5/ESYT2/ANXA3/ANXA2	5
GO:0015144	carbohydrate transmembrane transporter activity	4/1007	40/18367	0.174513578697187	0.513773350995074	SLC2A1/SLC5A3/SLC17A5/SLC45A4	4
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	2/1007	14/18367	0.177069288518981	0.513773350995074	B3GNT3/B3GNT2	2
GO:0015373	anion:sodium symporter activity	2/1007	14/18367	0.177069288518981	0.513773350995074	SLC6A4/SLC13A4	2
GO:0015562	efflux transmembrane transporter activity	2/1007	14/18367	0.177069288518981	0.513773350995074	GJA1/ABCB1	2
GO:0070411	I-SMAD binding	2/1007	14/18367	0.177069288518981	0.513773350995074	TGFBR1/CTNNB1	2
GO:0140666	annealing activity	2/1007	14/18367	0.177069288518981	0.513773350995074	SMARCA1/FMR1	2
GO:0004709	MAP kinase kinase kinase activity	3/1007	27/18367	0.182330756044139	0.519449857853845	EGFR/MAP3K4/MAP3K13	3
GO:0015215	nucleotide transmembrane transporter activity	3/1007	27/18367	0.182330756044139	0.519449857853845	SLC19A1/SLC25A36/SLC29A1	3
GO:0022884	macromolecule transmembrane transporter activity	3/1007	27/18367	0.182330756044139	0.519449857853845	ABCA1/SEC63/TOMM20	3
GO:0030507	spectrin binding	3/1007	27/18367	0.182330756044139	0.519449857853845	ANK3/MYO7A/CAMSAP2	3
GO:0043425	bHLH transcription factor binding	3/1007	27/18367	0.182330756044139	0.519449857853845	ISL1/KLF5/BHLHE41	3
GO:0051959	dynein light intermediate chain binding	3/1007	27/18367	0.182330756044139	0.519449857853845	DYNC1H1/DYNLL2/HOOK2	3
GO:0016859	cis-trans isomerase activity	4/1007	41/18367	0.185599889714137	0.52401405988153	DEGS1/NKTR/FKBP14/PPIB	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	4/1007	41/18367	0.185599889714137	0.52401405988153	ACSS1/SLC27A2/ACSF2/ACSL3	4
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/1007	41/18367	0.185599889714137	0.52401405988153	COL14A1/COL21A1/COL4A2/COL5A2	4
GO:0016829	lyase activity	14/1007	196/18367	0.188975724670849	0.530405083585707	GLDC/HACD3/PISD/APMAP/MGST3/HADHA/ECHDC2/UXS1/PDXDC1/AZIN1/ECHDC1/ACO1/FASN/ALAD	14
GO:0019842	vitamin binding	11/1007	148/18367	0.189307308897959	0.530405083585707	GLDC/SLC19A1/MTR/OPN3/FOLR1/SPTLC3/PDXDC1/P3H2/P3H1/FASN/TTPA	11
GO:0004866	endopeptidase inhibitor activity	13/1007	180/18367	0.18955091534293	0.530405083585707	ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/SERPINH1/BIRC6/CAST/USP14/PEBP1/ANXA2	13
GO:0015399	primary active transmembrane transporter activity	13/1007	181/18367	0.194722275670397	0.53235410343761	SLC26A2/ATP2B1/ATP13A3/ATP2B4/ABCA1/ATP6V1C2/CYB5A/ABCB1/ATP2A2/UQCRC1/NDUFB9/COX6A1/TOMM20	13
GO:0004725	protein tyrosine phosphatase activity	8/1007	102/18367	0.196417271752274	0.53235410343761	PTPN14/DUSP9/PTP4A1/PTPN1/PTPRM/DUSP14/PTPRA/DUSP5	8
GO:0003785	actin monomer binding	3/1007	28/18367	0.196462869454834	0.53235410343761	LIMA1/COBL/COBLL1	3
GO:0050681	androgen receptor binding	3/1007	28/18367	0.196462869454834	0.53235410343761	CALR/NSD1/TMF1	3
GO:0008307	structural constituent of muscle	4/1007	42/18367	0.196906768631653	0.53235410343761	DAG1/ASPH/DMD/PLEC	4
GO:0001846	opsonin binding	2/1007	15/18367	0.197292964273117	0.53235410343761	ITGAV/CALR	2
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	2/1007	15/18367	0.197292964273117	0.53235410343761	GABRE/GABRA4	2
GO:0048185	activin binding	2/1007	15/18367	0.197292964273117	0.53235410343761	TGFBR3/TGFBR1	2
GO:0071933	Arp2/3 complex binding	2/1007	15/18367	0.197292964273117	0.53235410343761	IQGAP2/WASF2	2
GO:0098847	sequence-specific single stranded DNA binding	2/1007	15/18367	0.197292964273117	0.53235410343761	RAD50/HNRNPA2B1	2
GO:1904680	peptide transmembrane transporter activity	2/1007	15/18367	0.197292964273117	0.53235410343761	GJA1/SLC13A3	2
GO:1990825	sequence-specific mRNA binding	2/1007	15/18367	0.197292964273117	0.53235410343761	FMR1/SRSF4	2
GO:0008168	methyltransferase activity	15/1007	214/18367	0.197586358645985	0.53235410343761	DNMT1/METTL7A/MTR/ASH1L/DNMT3A/SMYD2/SETD2/SUZ12/NSD1/TARBP1/KMT2C/CMTR1/PRDM2/PCMTD1/PCMTD2	15
GO:0043175	RNA polymerase core enzyme binding	5/1007	57/18367	0.201506552918471	0.541369456986093	NCOA3/BRD4/SMYD2/AGO2/HNRNPU	5
GO:0031490	chromatin DNA binding	8/1007	103/18367	0.203535112279284	0.545265939998195	ZFX/ACTN4/SUZ12/GRHL1/SMARCC1/SBNO1/HDAC2/HNRNPU	8
GO:0016504	peptidase activator activity	4/1007	43/18367	0.208416931681413	0.555392407610873	APP/FBLN1/PCOLCE2/VCP	4
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	3/1007	29/18367	0.210848867364467	0.555392407610873	CDK6/CDKL5/CDK7	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	3/1007	29/18367	0.210848867364467	0.555392407610873	DHCR24/FASN/TECR	3
GO:0035250	UDP-galactosyltransferase activity	3/1007	29/18367	0.210848867364467	0.555392407610873	B4GALT1/B3GNT3/B3GNT2	3
GO:0051787	misfolded protein binding	3/1007	29/18367	0.210848867364467	0.555392407610873	HSPA5/HSPA1B/HSPA9	3
GO:0097472	cyclin-dependent protein kinase activity	3/1007	29/18367	0.210848867364467	0.555392407610873	CDK6/CDKL5/CDK7	3
GO:0015103	inorganic anion transmembrane transporter activity	11/1007	152/18367	0.212663748813006	0.558612576965639	SLC26A2/SLC6A4/SLC13A4/GABRE/CLDN4/FXYD3/ANO6/SLC22A11/ANKH/SLC12A9/GABRA4	11
GO:0004698	calcium-dependent protein kinase C activity	2/1007	16/18367	0.217774583830367	0.561096810251465	PRKCI/PKN2	2
GO:0005092	GDP-dissociation inhibitor activity	2/1007	16/18367	0.217774583830367	0.561096810251465	CHML/GPSM2	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/1007	16/18367	0.217774583830367	0.561096810251465	SLC1A5/SLC1A3	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/1007	16/18367	0.217774583830367	0.561096810251465	SLC13A3/SLC1A5	2
GO:0035497	cAMP response element binding	2/1007	16/18367	0.217774583830367	0.561096810251465	CREB3L2/ATF6	2
GO:0042577	lipid phosphatase activity	2/1007	16/18367	0.217774583830367	0.561096810251465	PLPP3/SGPP1	2
GO:1990404	protein ADP-ribosylase activity	2/1007	16/18367	0.217774583830367	0.561096810251465	PARP1/TNKS2	2
GO:0016279	protein-lysine N-methyltransferase activity	5/1007	59/18367	0.221381730333229	0.5672906839789	ASH1L/SMYD2/SETD2/NSD1/KMT2C	5
GO:0036002	pre-mRNA binding	5/1007	59/18367	0.221381730333229	0.5672906839789	SF1/TRA2B/PRPF8/HNRNPU/SRSF2	5
GO:0061630	ubiquitin protein ligase activity	20/1007	304/18367	0.230378081273905	0.583898355171441	RNF43/ZNRF3/RNF128/MDM2/NHLRC3/RNF217/HECTD1/TRIM44/HUWE1/SIAH1/UBE4B/SIAH2/MYCBP2/NEDD4/TRIM24/WWP1/MYLIP/UBR5/UBR4/HERC2	20
GO:0016278	lysine N-methyltransferase activity	5/1007	60/18367	0.2315350797615	0.583898355171441	ASH1L/SMYD2/SETD2/NSD1/KMT2C	5
GO:0004715	non-membrane spanning protein tyrosine kinase activity	4/1007	45/18367	0.231977936764509	0.583898355171441	YES1/WEE1/BAZ1B/PTK2	4
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	11/1007	156/18367	0.23715124258477	0.583898355171441	DNMT1/ASH1L/DNMT3A/SMYD2/SETD2/NSD1/TARBP1/KMT2C/CMTR1/PCMTD1/PCMTD2	11
GO:0004697	protein kinase C activity	2/1007	17/18367	0.238425181492405	0.583898355171441	PRKCI/PKN2	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/1007	17/18367	0.238425181492405	0.583898355171441	PTPRM/PTPRA	2
GO:0005324	long-chain fatty acid transporter activity	2/1007	17/18367	0.238425181492405	0.583898355171441	SLC2A1/SLC27A2	2
GO:0008484	sulfuric ester hydrolase activity	2/1007	17/18367	0.238425181492405	0.583898355171441	STS/GNS	2
GO:0008525	phosphatidylcholine transporter activity	2/1007	17/18367	0.238425181492405	0.583898355171441	ABCA1/ABCB1	2
GO:0015095	magnesium ion transmembrane transporter activity	2/1007	17/18367	0.238425181492405	0.583898355171441	TUSC3/ZDHHC17	2
GO:0015116	sulfate transmembrane transporter activity	2/1007	17/18367	0.238425181492405	0.583898355171441	SLC26A2/SLC13A4	2
GO:0015377	cation:chloride symporter activity	2/1007	17/18367	0.238425181492405	0.583898355171441	SLC6A4/SLC12A9	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/1007	17/18367	0.238425181492405	0.583898355171441	PTPRM/PTPRA	2
GO:0031489	myosin V binding	2/1007	17/18367	0.238425181492405	0.583898355171441	FUS/RAB6A	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/1007	17/18367	0.238425181492405	0.583898355171441	ASH1L/KMT2C	2
GO:0070628	proteasome binding	2/1007	17/18367	0.238425181492405	0.583898355171441	RAD23B/USP14	2
GO:0043130	ubiquitin binding	7/1007	92/18367	0.239832359454501	0.583898355171441	N4BP2/MDM2/USP25/RAD23B/NEDD4/UBR5/TAB3	7
GO:0031210	phosphatidylcholine binding	3/1007	31/18367	0.24024661909493	0.583898355171441	NF1/ABCA1/ESYT2	3
GO:0071813	lipoprotein particle binding	3/1007	31/18367	0.24024661909493	0.583898355171441	COLEC12/HSPD1/ABCA1	3
GO:0071814	protein-lipid complex binding	3/1007	31/18367	0.24024661909493	0.583898355171441	COLEC12/HSPD1/ABCA1	3
GO:0005507	copper ion binding	5/1007	61/18367	0.241818248876527	0.586207220284228	F5/P2RX4/SOD3/SUMF1/GPC1	5
GO:0070851	growth factor receptor binding	10/1007	141/18367	0.24557575821193	0.593789589727819	APP/EFEMP1/IL6ST/VAV3/CD2AP/NCSTN/YES1/GATA3/ATXN2/SNX4	10
GO:0072341	modified amino acid binding	7/1007	93/18367	0.24816379310787	0.59851267749545	MME/SLC19A1/SCIN/FOLR1/SYT7/FASN/ANXA2	7
GO:0016741	transferase activity, transferring one-carbon groups	15/1007	225/18367	0.253612351733648	0.603437933319349	DNMT1/METTL7A/MTR/ASH1L/DNMT3A/SMYD2/SETD2/SUZ12/NSD1/TARBP1/KMT2C/CMTR1/PRDM2/PCMTD1/PCMTD2	15
GO:0009055	electron transfer activity	9/1007	126/18367	0.254449102566206	0.603437933319349	GLDC/DEGS1/ASPH/CYB5A/ADH5/ETFA/UQCRC1/NDUFB9/COX6A1	9
GO:0015605	organophosphate ester transmembrane transporter activity	3/1007	32/18367	0.25519305010524	0.603437933319349	SLC19A1/SLC25A36/SLC29A1	3
GO:0031624	ubiquitin conjugating enzyme binding	3/1007	32/18367	0.25519305010524	0.603437933319349	RNF217/SIAH1/SIAH2	3
GO:0050699	WW domain binding	3/1007	32/18367	0.25519305010524	0.603437933319349	TP63/TCEAL4/NDFIP2	3
GO:0051721	protein phosphatase 2A binding	3/1007	32/18367	0.25519305010524	0.603437933319349	PTPN1/BOD1L1/BCL2	3
GO:0001221	transcription coregulator binding	6/1007	78/18367	0.255680536083938	0.603437933319349	SUZ12/VGLL4/CTNNB1/TFAM/CHD6/NFE2L2	6
GO:0005044	scavenger receptor activity	4/1007	47/18367	0.256145429788629	0.603437933319349	COLEC12/LRP1/PRSS12/LGALS3BP	4
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4/1007	47/18367	0.256145429788629	0.603437933319349	DUSP9/PTP4A1/DUSP14/DUSP5	4
GO:0000295	adenine nucleotide transmembrane transporter activity	2/1007	18/18367	0.259164753970664	0.603437933319349	SLC19A1/SLC29A1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/1007	18/18367	0.259164753970664	0.603437933319349	SLC19A1/SLC29A1	2
GO:0008569	minus-end-directed microtubule motor activity	2/1007	18/18367	0.259164753970664	0.603437933319349	DYNC1H1/KIFC3	2
GO:0098918	structural constituent of synapse	2/1007	18/18367	0.259164753970664	0.603437933319349	DLG1/ERC1	2
GO:0099095	ligand-gated anion channel activity	2/1007	18/18367	0.259164753970664	0.603437933319349	GABRE/GABRA4	2
GO:0061135	endopeptidase regulator activity	13/1007	194/18367	0.267312248844459	0.620875494237254	ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/SERPINH1/BIRC6/CAST/USP14/PEBP1/ANXA2	13
GO:0140097	catalytic activity, acting on DNA	15/1007	229/18367	0.275354130653255	0.636062695161022	SMARCA2/DNMT1/SMARCA1/DNMT3A/RAD50/ATRX/BPTF/SMARCA5/DICER1/TOP2B/NAV2/DHX36/DDX1/CDK7/CHD6	15
GO:0000339	RNA cap binding	2/1007	19/18367	0.279921546650927	0.636062695161022	NCBP3/AGO2	2
GO:0004129	cytochrome-c oxidase activity	2/1007	19/18367	0.279921546650927	0.636062695161022	CYB5A/COX6A1	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/1007	19/18367	0.279921546650927	0.636062695161022	GALNT11/GALNT18	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/1007	19/18367	0.279921546650927	0.636062695161022	TGFBR3/TGFBR1	2
GO:0004890	GABA-A receptor activity	2/1007	19/18367	0.279921546650927	0.636062695161022	GABRE/GABRA4	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/1007	19/18367	0.279921546650927	0.636062695161022	SLC6A4/SLC29A1	2
GO:0035613	RNA stem-loop binding	2/1007	19/18367	0.279921546650927	0.636062695161022	MYH10/FMR1	2
GO:0035615	clathrin adaptor activity	2/1007	19/18367	0.279921546650927	0.636062695161022	STON1/AP2A2	2
GO:0015020	glucuronosyltransferase activity	3/1007	34/18367	0.285426507066162	0.643916737232993	CHPF/EXT2/B4GAT1	3
GO:0016248	channel inhibitor activity	3/1007	34/18367	0.285426507066162	0.643916737232993	RASA1/NEDD4/BCL2	3
GO:0030291	protein serine/threonine kinase inhibitor activity	3/1007	34/18367	0.285426507066162	0.643916737232993	PKIB/CDKN1C/HEXIM1	3
GO:0030159	signaling receptor complex adaptor activity	4/1007	50/18367	0.293240225857617	0.659965472514877	DLG5/SPAG9/SORBS1/SHANK2	4
GO:0016018	cyclosporin A binding	2/1007	20/18367	0.300631391059105	0.665482163776375	NKTR/PPIB	2
GO:0016408	C-acyltransferase activity	2/1007	20/18367	0.300631391059105	0.665482163776375	HADHA/SPTLC3	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/1007	20/18367	0.300631391059105	0.665482163776375	CYB5A/COX6A1	2
GO:0030296	protein tyrosine kinase activator activity	2/1007	20/18367	0.300631391059105	0.665482163776375	CD24/ERBB3	2
GO:0031418	L-ascorbic acid binding	2/1007	20/18367	0.300631391059105	0.665482163776375	P3H2/P3H1	2
GO:0042288	MHC class I protein binding	2/1007	20/18367	0.300631391059105	0.665482163776375	BCAP31/VCP	2
GO:0140312	cargo adaptor activity	2/1007	20/18367	0.300631391059105	0.665482163776375	STON1/AP2A2	2
GO:0003743	translation initiation factor activity	4/1007	51/18367	0.30576525222514	0.675261435241936	EIF3A/EIF4G1/AGO2/DENR	4
GO:0042162	telomeric DNA binding	3/1007	36/18367	0.315922873974155	0.694905002184861	RAD50/PURA/HNRNPA2B1	3
GO:0004879	nuclear receptor activity	4/1007	52/18367	0.318344343885148	0.694905002184861	NR2F2/ESRRG/PPARG/NR2F6	4
GO:0098531	ligand-activated transcription factor activity	4/1007	52/18367	0.318344343885148	0.694905002184861	NR2F2/ESRRG/PPARG/NR2F6	4
GO:0001848	complement binding	2/1007	21/18367	0.321237090067783	0.694905002184861	CALR/CD59	2
GO:0005243	gap junction channel activity	2/1007	21/18367	0.321237090067783	0.694905002184861	GJA1/GJA5	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/1007	21/18367	0.321237090067783	0.694905002184861	SLC19A1/SLC29A1	2
GO:0051010	microtubule plus-end binding	2/1007	21/18367	0.321237090067783	0.694905002184861	CLIP1/DST	2
GO:1990381	ubiquitin-specific protease binding	2/1007	21/18367	0.321237090067783	0.694905002184861	CLTC/VCP	2
GO:0043177	organic acid binding	9/1007	135/18367	0.321856600472869	0.694905002184861	GLDC/NR2F2/SLC19A1/FOLR1/SLC1A3/PPARG/P3H2/ASS1/P3H1	9
GO:0015081	sodium ion transmembrane transporter activity	10/1007	152/18367	0.322661760110906	0.694905002184861	SLC6A4/SLC13A4/SLC38A1/SLC5A3/SLC13A3/SLC9A1/SLC1A3/SLC5A6/SLC20A2/SLC38A2	10
GO:0050660	flavin adenine dinucleotide binding	6/1007	85/18367	0.322766056157974	0.694905002184861	CYB5R1/ACADVL/DHCR24/MICAL3/ETFA/SQLE	6
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	11/1007	170/18367	0.329787237597882	0.708404020625975	DEGS1/ASPH/P4HB/KDM5B/TET2/CYP2J2/P3H2/KDM4B/P3H1/MICAL3/SQLE	11
GO:0016409	palmitoyltransferase activity	3/1007	37/18367	0.331202928853922	0.709828095248292	SPTLC3/CPT2/ZDHHC17	3
GO:0001098	basal transcription machinery binding	5/1007	70/18367	0.338482153582486	0.720831410054709	NCOA3/BRD4/SMYD2/AGO2/HNRNPU	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/1007	70/18367	0.338482153582486	0.720831410054709	NCOA3/BRD4/SMYD2/AGO2/HNRNPU	5
GO:0005085	guanyl-nucleotide exchange factor activity	14/1007	223/18367	0.339602719489046	0.720831410054709	ADRB1/DOCK9/NET1/VAV3/DENND4C/DOCK8/MYCBP2/CYTH3/SWAP70/ARFGEF3/DOCK1/ARFGEF1/GAPVD1/HERC2	14
GO:0004602	glutathione peroxidase activity	2/1007	22/18367	0.341687847608118	0.720831410054709	MGST3/GPX8	2
GO:0005355	glucose transmembrane transporter activity	2/1007	22/18367	0.341687847608118	0.720831410054709	SLC2A1/SLC5A3	2
GO:0015149	hexose transmembrane transporter activity	2/1007	22/18367	0.341687847608118	0.720831410054709	SLC2A1/SLC5A3	2
GO:0016917	GABA receptor activity	2/1007	22/18367	0.341687847608118	0.720831410054709	GABRE/GABRA4	2
GO:0015459	potassium channel regulator activity	4/1007	54/18367	0.343605281872973	0.723258439299584	RASA1/AKAP9/DLG1/SLC5A3	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/1007	38/18367	0.346471360841037	0.727667022879951	NKTR/FKBP14/PPIB	3
GO:0031491	nucleosome binding	5/1007	71/18367	0.349492991144902	0.732381979221429	SMARCA1/SMARCA5/HP1BP3/SMARCC1/HDAC2	5
GO:0048306	calcium-dependent protein binding	6/1007	88/18367	0.352294501337112	0.736615775523052	ATP2B4/SEC31A/CLN3/SLC9A1/ANXA3/ANXA2	6
GO:0003678	DNA helicase activity	5/1007	72/18367	0.36052217064186	0.745730718749625	RAD50/ATRX/NAV2/DHX36/CHD6	5
GO:0045182	translation regulator activity	9/1007	140/18367	0.360757465756512	0.745730718749625	IGF2BP3/EIF3A/EIF2AK1/EIF4G1/FMR1/PURA/EIF2AK4/AGO2/DENR	9
GO:0050997	quaternary ammonium group binding	3/1007	39/18367	0.361705222479117	0.745730718749625	NF1/ABCA1/ESYT2	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/1007	23/18367	0.361938739862363	0.745730718749625	PARP1/TNKS2	2
GO:0008483	transaminase activity	2/1007	23/18367	0.361938739862363	0.745730718749625	GFPT1/BCAT1	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/1007	23/18367	0.361938739862363	0.745730718749625	PRKCI/PKN2	2
GO:0019888	protein phosphatase regulator activity	6/1007	89/18367	0.362189468915512	0.745730718749625	PHACTR2/PPP4R1/BOD1L1/PPP2R2B/PPP6R2/PPP1R10	6
GO:0140104	molecular carrier activity	5/1007	73/18367	0.371560534768142	0.763358571429974	TNPO1/EMC1/RANBP17/EMC10/EMC7	5
GO:0042169	SH2 domain binding	3/1007	40/18367	0.376882923326301	0.772571753846178	DAG1/ARHGAP5/PTK2	3
GO:0000030	mannosyltransferase activity	2/1007	24/18367	0.381950225109747	0.772571753846178	DPY19L1/TMTC3	2
GO:0010857	calcium-dependent protein kinase activity	2/1007	24/18367	0.381950225109747	0.772571753846178	PRKCI/PKN2	2
GO:0015145	monosaccharide transmembrane transporter activity	2/1007	24/18367	0.381950225109747	0.772571753846178	SLC2A1/SLC5A3	2
GO:0015295	solute:proton symporter activity	2/1007	24/18367	0.381950225109747	0.772571753846178	SLC17A5/SLC45A4	2
GO:0016769	transferase activity, transferring nitrogenous groups	2/1007	24/18367	0.381950225109747	0.772571753846178	GFPT1/BCAT1	2
GO:0005254	chloride channel activity	5/1007	74/18367	0.382599161236655	0.772571753846178	GABRE/CLDN4/FXYD3/ANO6/GABRA4	5
GO:0019905	syntaxin binding	5/1007	74/18367	0.382599161236655	0.772571753846178	SLC6A4/ABCA1/SYT7/TMED9/GOLGA2	5
GO:0048487	beta-tubulin binding	3/1007	41/18367	0.391984215453577	0.785470500228345	EML4/LRPPRC/GABARAPL1	3
GO:0008047	enzyme activator activity	7/1007	110/18367	0.398751732194137	0.785470500228345	DDOST/MMP15/SUZ12/GM2A/AZIN1/ARL1/GNAS	7
GO:0042277	peptide binding	19/1007	321/18367	0.398829062903941	0.785470500228345	MME/ENPEP/LRPAP1/SLC40A1/IGF1R/LRP1/PRLR/CALR/NKTR/CTSV/TNPO1/DHCR24/CLSTN1/NPEPPS/PPARG/FZD5/PPIB/KDELR1/TOMM20	19
GO:0005112	Notch binding	2/1007	25/18367	0.401687689583244	0.785470500228345	GALNT11/AAK1	2
GO:0051019	mitogen-activated protein kinase binding	2/1007	25/18367	0.401687689583244	0.785470500228345	TPR/MAPK14	2
GO:0019205	nucleobase-containing compound kinase activity	3/1007	42/18367	0.406990172901417	0.785470500228345	N4BP2/DLG1/AK3	3
GO:0019894	kinesin binding	3/1007	42/18367	0.406990172901417	0.785470500228345	KTN1/SPAG9/CLSTN1	3
GO:0001786	phosphatidylserine binding	4/1007	60/18367	0.41922598403747	0.785470500228345	MME/SCIN/SYT7/ANXA2	4
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	4/1007	60/18367	0.41922598403747	0.785470500228345	ACADVL/DHCR24/FASN/TECR	4
GO:0015078	proton transmembrane transporter activity	8/1007	130/18367	0.42081298038545	0.785470500228345	ATP6V1C2/ATP6V1B1/SLC9A1/CYB5A/SLC17A5/SLC45A4/UQCRC1/COX6A1	8
GO:0008198	ferrous iron binding	2/1007	26/18367	0.42112102686795	0.785470500228345	TET2/CDO1	2
GO:0030371	translation repressor activity	2/1007	26/18367	0.42112102686795	0.785470500228345	FMR1/PURA	2
GO:0099604	ligand-gated calcium channel activity	2/1007	26/18367	0.42112102686795	0.785470500228345	MCOLN3/P2RX4	2
GO:0032266	phosphatidylinositol-3-phosphate binding	3/1007	43/18367	0.421883165992918	0.785470500228345	SNX13/PARD3/PLEKHA5	3
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/1007	10/18367	0.431077375525649	0.785470500228345	RAD50	1
GO:0004955	prostaglandin receptor activity	1/1007	10/18367	0.431077375525649	0.785470500228345	PPARG	1
GO:0005384	manganese ion transmembrane transporter activity	1/1007	10/18367	0.431077375525649	0.785470500228345	TMEM165	1
GO:0008097	5S rRNA binding	1/1007	10/18367	0.431077375525649	0.785470500228345	MDM2	1
GO:0008190	eukaryotic initiation factor 4E binding	1/1007	10/18367	0.431077375525649	0.785470500228345	EIF4G1	1
GO:0008239	dipeptidyl-peptidase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	DPP4	1
GO:0015643	toxic substance binding	1/1007	10/18367	0.431077375525649	0.785470500228345	ASS1	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	PIK3CB	1
GO:0016595	glutamate binding	1/1007	10/18367	0.431077375525649	0.785470500228345	SLC1A3	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/1007	10/18367	0.431077375525649	0.785470500228345	CYB5R1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/1007	10/18367	0.431077375525649	0.785470500228345	DEGS1	1
GO:0016783	sulfurtransferase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	MOCS2	1
GO:0017002	activin-activated receptor activity	1/1007	10/18367	0.431077375525649	0.785470500228345	TGFBR1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/1007	10/18367	0.431077375525649	0.785470500228345	ADH5	1
GO:0019531	oxalate transmembrane transporter activity	1/1007	10/18367	0.431077375525649	0.785470500228345	SLC26A2	1
GO:0030957	Tat protein binding	1/1007	10/18367	0.431077375525649	0.785470500228345	GABARAPL1	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/1007	10/18367	0.431077375525649	0.785470500228345	HDAC2	1
GO:0031419	cobalamin binding	1/1007	10/18367	0.431077375525649	0.785470500228345	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	SLC27A2	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/1007	10/18367	0.431077375525649	0.785470500228345	HDAC2	1
GO:0034511	U3 snoRNA binding	1/1007	10/18367	0.431077375525649	0.785470500228345	PRKDC	1
GO:0034713	type I transforming growth factor beta receptor binding	1/1007	10/18367	0.431077375525649	0.785470500228345	FERMT2	1
GO:0035612	AP-2 adaptor complex binding	1/1007	10/18367	0.431077375525649	0.785470500228345	AAK1	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/1007	10/18367	0.431077375525649	0.785470500228345	ASH1L	1
GO:0047760	butyrate-CoA ligase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	ACSF2	1
GO:0051864	histone H3-methyl-lysine-36 demethylase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	KDM4B	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	PIK3CB	1
GO:0070008	serine-type exopeptidase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	CPD	1
GO:0070016	armadillo repeat domain binding	1/1007	10/18367	0.431077375525649	0.785470500228345	TCF7L2	1
GO:0070567	cytidylyltransferase activity	1/1007	10/18367	0.431077375525649	0.785470500228345	CDS1	1
GO:0098505	G-rich strand telomeric DNA binding	1/1007	10/18367	0.431077375525649	0.785470500228345	HNRNPA2B1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/1007	10/18367	0.431077375525649	0.785470500228345	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/1007	10/18367	0.431077375525649	0.785470500228345	PLEKHA8	1
GO:0043621	protein self-association	4/1007	61/18367	0.431675649662799	0.785470500228345	SLC2A1/PPARG/PLEC/GPSM2	4
GO:0043021	ribonucleoprotein complex binding	9/1007	149/18367	0.431755472490505	0.785470500228345	HSPA5/RPN2/CCDC47/SND1/MDM2/FMR1/NEMF/SECISBP2/HNRNPU	9
GO:0022839	ion gated channel activity	3/1007	44/18367	0.436646831310994	0.785470500228345	ANO6/KCNN4/TMEM63A	3
GO:0140677	molecular function activator activity	9/1007	150/18367	0.439640356364666	0.785470500228345	TOR1AIP2/DDOST/MMP15/DNAJB4/SUZ12/GM2A/AZIN1/ARL1/GNAS	9
GO:0016791	phosphatase activity	16/1007	275/18367	0.440045058341717	0.785470500228345	DLG1/PTPN14/CTDSPL/PLPP3/CAMK2G/DUSP9/PTP4A1/PTPN1/PTPRM/PPP4R1/DUSP14/SGPP1/PTPRA/TNS3/PDP2/DUSP5	16
GO:0001671	ATPase activator activity	2/1007	27/18367	0.440224248533855	0.785470500228345	TOR1AIP2/DNAJB4	2
GO:0051119	sugar transmembrane transporter activity	2/1007	27/18367	0.440224248533855	0.785470500228345	SLC2A1/SLC5A3	2
GO:0051393	alpha-actinin binding	2/1007	27/18367	0.440224248533855	0.785470500228345	DAG1/PPARG	2
GO:0004896	cytokine receptor activity	6/1007	97/18367	0.441348837609072	0.785470500228345	CSF3R/CSF2RA/PRLR/IL10RB/IL6ST/LIFR	6
GO:0004722	protein serine/threonine phosphatase activity	6/1007	98/18367	0.451152775016545	0.785470500228345	CTDSPL/CAMK2G/DUSP9/DUSP14/PDP2/DUSP5	6
GO:0046875	ephrin receptor binding	2/1007	28/18367	0.458975123847626	0.785470500228345	EFNA1/PTPN1	2
GO:0051861	glycolipid binding	2/1007	28/18367	0.458975123847626	0.785470500228345	PLEKHA8/CLN3	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/1007	28/18367	0.458975123847626	0.785470500228345	PLEKHA5/SNX14	2
GO:0000774	adenyl-nucleotide exchange factor activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SIL1	1
GO:0004954	prostanoid receptor activity	1/1007	11/18367	0.462286455595686	0.785470500228345	PPARG	1
GO:0005049	nuclear export signal receptor activity	1/1007	11/18367	0.462286455595686	0.785470500228345	RANBP17	1
GO:0005078	MAP-kinase scaffold activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SPAG9	1
GO:0005247	voltage-gated chloride channel activity	1/1007	11/18367	0.462286455595686	0.785470500228345	ANO6	1
GO:0005436	sodium:phosphate symporter activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SLC20A2	1
GO:0005536	glucose binding	1/1007	11/18367	0.462286455595686	0.785470500228345	UGP2	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/1007	11/18367	0.462286455595686	0.785470500228345	PKIB	1
GO:0010485	H4 histone acetyltransferase activity	1/1007	11/18367	0.462286455595686	0.785470500228345	USP22	1
GO:0015378	sodium:chloride symporter activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SLC9A1	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/1007	11/18367	0.462286455595686	0.785470500228345	GLCE	1
GO:0017128	phospholipid scramblase activity	1/1007	11/18367	0.462286455595686	0.785470500228345	ANO6	1
GO:0019107	myristoyltransferase activity	1/1007	11/18367	0.462286455595686	0.785470500228345	ZDHHC17	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/1007	11/18367	0.462286455595686	0.785470500228345	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/1007	11/18367	0.462286455595686	0.785470500228345	DLG1	1
GO:0035252	UDP-xylosyltransferase activity	1/1007	11/18367	0.462286455595686	0.785470500228345	GXYLT1	1
GO:0042285	xylosyltransferase activity	1/1007	11/18367	0.462286455595686	0.785470500228345	GXYLT1	1
GO:0043560	insulin receptor substrate binding	1/1007	11/18367	0.462286455595686	0.785470500228345	IGF1R	1
GO:0051400	BH domain binding	1/1007	11/18367	0.462286455595686	0.785470500228345	BCL2	1
GO:0070513	death domain binding	1/1007	11/18367	0.462286455595686	0.785470500228345	BCL2	1
GO:0097157	pre-mRNA intronic binding	1/1007	11/18367	0.462286455595686	0.785470500228345	PRPF8	1
GO:0097371	MDM2/MDM4 family protein binding	1/1007	11/18367	0.462286455595686	0.785470500228345	TP63	1
GO:0099186	structural constituent of postsynapse	1/1007	11/18367	0.462286455595686	0.785470500228345	DLG1	1
GO:1901474	azole transmembrane transporter activity	1/1007	11/18367	0.462286455595686	0.785470500228345	SLC19A3	1
GO:1901612	cardiolipin binding	1/1007	11/18367	0.462286455595686	0.785470500228345	MME	1
GO:1990226	histone methyltransferase binding	1/1007	11/18367	0.462286455595686	0.785470500228345	CTNNB1	1
GO:1990459	transferrin receptor binding	1/1007	11/18367	0.462286455595686	0.785470500228345	SNX4	1
GO:0004864	protein phosphatase inhibitor activity	3/1007	46/18367	0.465726851490962	0.789892843446001	PHACTR2/BOD1L1/PPP1R10	3
GO:0015301	anion:anion antiporter activity	2/1007	29/18367	0.477354846550082	0.799548171042145	SLC26A2/SLC19A1	2
GO:0032452	histone demethylase activity	2/1007	29/18367	0.477354846550082	0.799548171042145	KDM5B/KDM4B	2
GO:0033612	receptor serine/threonine kinase binding	2/1007	29/18367	0.477354846550082	0.799548171042145	BMP7/MDM2	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/1007	29/18367	0.477354846550082	0.799548171042145	PLEKHA1/TTPA	2
GO:0051059	NF-kappaB binding	2/1007	29/18367	0.477354846550082	0.799548171042145	GSK3B/HDAC2	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/1007	29/18367	0.477354846550082	0.799548171042145	PLEKHA8/PLEKHA5	2
GO:0140457	protein demethylase activity	2/1007	29/18367	0.477354846550082	0.799548171042145	KDM5B/KDM4B	2
GO:0005262	calcium channel activity	7/1007	119/18367	0.479872846206326	0.799850867106862	ITGAV/MCOLN3/TRPV6/P2RX4/TRPM7/CUL5/ANXA2	7
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	3/1007	47/18367	0.480016493879757	0.799850867106862	ADRB1/GABRE/GABRA4	3
GO:0005095	GTPase inhibitor activity	1/1007	12/18367	0.491785123018607	0.799850867106862	IQGAP2	1
GO:0008174	mRNA methyltransferase activity	1/1007	12/18367	0.491785123018607	0.799850867106862	CMTR1	1
GO:0015166	polyol transmembrane transporter activity	1/1007	12/18367	0.491785123018607	0.799850867106862	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/1007	12/18367	0.491785123018607	0.799850867106862	KCNN4	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/1007	12/18367	0.491785123018607	0.799850867106862	SLC22A5	1
GO:0034452	dynactin binding	1/1007	12/18367	0.491785123018607	0.799850867106862	GSK3B	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/1007	12/18367	0.491785123018607	0.799850867106862	PIK3CB	1
GO:0035256	G protein-coupled glutamate receptor binding	1/1007	12/18367	0.491785123018607	0.799850867106862	HOMER1	1
GO:0042975	peroxisome proliferator activated receptor binding	1/1007	12/18367	0.491785123018607	0.799850867106862	MDM2	1
GO:0043176	amine binding	1/1007	12/18367	0.491785123018607	0.799850867106862	SLC6A4	1
GO:0043422	protein kinase B binding	1/1007	12/18367	0.491785123018607	0.799850867106862	SRSF5	1
GO:0046790	virion binding	1/1007	12/18367	0.491785123018607	0.799850867106862	ANXA2	1
GO:0051378	serotonin binding	1/1007	12/18367	0.491785123018607	0.799850867106862	SLC6A4	1
GO:0097677	STAT family protein binding	1/1007	12/18367	0.491785123018607	0.799850867106862	PPARG	1
GO:0043022	ribosome binding	4/1007	66/18367	0.492632862037254	0.799850867106862	HSPA5/RPN2/CCDC47/FMR1	4
GO:0070888	E-box binding	3/1007	48/18367	0.494123303726197	0.799850867106862	PPARG/BHLHE41/GATA3	3
GO:0120013	lipid transfer activity	3/1007	48/18367	0.494123303726197	0.799850867106862	ABCA1/PLEKHA8/TTPA	3
GO:0016417	S-acyltransferase activity	2/1007	30/18367	0.495347726819096	0.799850867106862	ZDHHC17/FASN	2
GO:0022829	wide pore channel activity	2/1007	30/18367	0.495347726819096	0.799850867106862	GJA1/GJA5	2
GO:0031406	carboxylic acid binding	10/1007	176/18367	0.500261823273597	0.806404956148721	GLDC/NR2F2/SLC19A1/FOLR1/SIGLEC6/SLC1A3/PPARG/ADH5/P3H2/P3H1	10
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	25/1007	450/18367	0.502518668219043	0.807806877628845	TFDP2/NFAT5/PBX1/ZFAT/FOXO4/GTF2I/TFAP2A/TFCP2L1/TFAP2C/ISL1/ATMIN/ESRRG/CREB3L2/KLF5/TP63/ZNF33A/IRF6/GRHL1/GATA3/PRDM2/MEIS2/ATF6/ZNF721/YY1/NFE2L2	25
GO:0019212	phosphatase inhibitor activity	3/1007	49/18367	0.508036693482586	0.807806877628845	PHACTR2/BOD1L1/PPP1R10	3
GO:0140142	nucleocytoplasmic carrier activity	2/1007	31/18367	0.512940906662141	0.807806877628845	TNPO1/RANBP17	2
GO:0003684	damaged DNA binding	4/1007	68/18367	0.51625145782668	0.807806877628845	DDB1/RAD23B/TP63/XPC	4
GO:1990782	protein tyrosine kinase binding	6/1007	105/18367	0.518413226110416	0.807806877628845	ITGB1/PTPN14/EIF3A/PTPN1/HSP90AA1/NEDD9	6
GO:0002161	aminoacyl-tRNA editing activity	1/1007	13/18367	0.519667028827393	0.807806877628845	IARS2	1
GO:0004312	fatty acid synthase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	FASN	1
GO:0008195	phosphatidate phosphatase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	PLPP3	1
GO:0008417	fucosyltransferase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	FUT8	1
GO:0015385	sodium:proton antiporter activity	1/1007	13/18367	0.519667028827393	0.807806877628845	SLC9A1	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	TARBP1	1
GO:0016594	glycine binding	1/1007	13/18367	0.519667028827393	0.807806877628845	GLDC	1
GO:0016840	carbon-nitrogen lyase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	APMAP	1
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	KDM4B	1
GO:0045159	myosin II binding	1/1007	13/18367	0.519667028827393	0.807806877628845	TRIOBP	1
GO:0045504	dynein heavy chain binding	1/1007	13/18367	0.519667028827393	0.807806877628845	DYNC1LI2	1
GO:0060590	ATPase regulator activity	1/1007	13/18367	0.519667028827393	0.807806877628845	SIL1	1
GO:0070700	BMP receptor binding	1/1007	13/18367	0.519667028827393	0.807806877628845	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/1007	13/18367	0.519667028827393	0.807806877628845	HSD17B1	1
GO:0140299	small molecule sensor activity	1/1007	13/18367	0.519667028827393	0.807806877628845	TMEM63A	1
GO:0140333	glycerophospholipid flippase activity	1/1007	13/18367	0.519667028827393	0.807806877628845	ABCB1	1
GO:0005048	signal sequence binding	3/1007	50/18367	0.521747106309711	0.807806877628845	TNPO1/KDELR1/TOMM20	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/1007	50/18367	0.521747106309711	0.807806877628845	CCND1/CDKN1C/HEXIM1	3
GO:0140359	ABC-type transporter activity	3/1007	50/18367	0.521747106309711	0.807806877628845	ATP13A3/ABCA1/ABCB1	3
GO:0005253	anion channel activity	5/1007	87/18367	0.522547396981543	0.807806877628845	GABRE/CLDN4/FXYD3/ANO6/GABRA4	5
GO:0001216	DNA-binding transcription activator activity	25/1007	456/18367	0.529904011336553	0.809483099979483	TFDP2/NFAT5/PBX1/ZFAT/FOXO4/GTF2I/TFAP2A/TFCP2L1/TFAP2C/ISL1/ATMIN/ESRRG/CREB3L2/KLF5/TP63/ZNF33A/IRF6/GRHL1/GATA3/PRDM2/MEIS2/ATF6/ZNF721/YY1/NFE2L2	25
GO:0001223	transcription coactivator binding	2/1007	32/18367	0.530124097099268	0.809483099979483	VGLL4/TFAM	2
GO:0030515	snoRNA binding	2/1007	32/18367	0.530124097099268	0.809483099979483	NUDT4/PRKDC	2
GO:0051219	phosphoprotein binding	5/1007	88/18367	0.532803595514341	0.809483099979483	RASA1/CBX4/YES1/NEDD4/PRKCSH	5
GO:0004601	peroxidase activity	3/1007	51/18367	0.535245972189997	0.809483099979483	MGST3/PRDX4/GPX8	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	17/1007	310/18367	0.535411232323517	0.809483099979483	PEG3/NFE2L3/TFAP2A/TFAP2C/ZFHX3/IRX2/HIC2/ZNF440/AEBP2/PPARG/ZNF439/BHLHE41/NR2F6/GATA3/PRDM2/PURB/YY1	17
GO:0019208	phosphatase regulator activity	6/1007	107/18367	0.5370541728031	0.809483099979483	PHACTR2/PPP4R1/BOD1L1/PPP2R2B/PPP6R2/PPP1R10	6
GO:0051087	chaperone binding	6/1007	107/18367	0.5370541728031	0.809483099979483	LRP2/HSPA5/CALR/HSPD1/ERP29/DNAJB4	6
GO:0015297	antiporter activity	5/1007	89/18367	0.54295919828808	0.809483099979483	SLC26A2/SLC19A1/SLC7A6/SLC9A1/SLC35D1	5
GO:0004065	arylsulfatase activity	1/1007	14/18367	0.546020701158809	0.809483099979483	STS	1
GO:0004707	MAP kinase activity	1/1007	14/18367	0.546020701158809	0.809483099979483	MAPK14	1
GO:0005172	vascular endothelial growth factor receptor binding	1/1007	14/18367	0.546020701158809	0.809483099979483	CD2AP	1
GO:0005313	L-glutamate transmembrane transporter activity	1/1007	14/18367	0.546020701158809	0.809483099979483	SLC1A3	1
GO:0005451	monovalent cation:proton antiporter activity	1/1007	14/18367	0.546020701158809	0.809483099979483	SLC9A1	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/1007	14/18367	0.546020701158809	0.809483099979483	LYPLA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/1007	14/18367	0.546020701158809	0.809483099979483	ECI2	1
GO:0030983	mismatched DNA binding	1/1007	14/18367	0.546020701158809	0.809483099979483	XPC	1
GO:0036041	long-chain fatty acid binding	1/1007	14/18367	0.546020701158809	0.809483099979483	PPARG	1
GO:0043023	ribosomal large subunit binding	1/1007	14/18367	0.546020701158809	0.809483099979483	NEMF	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/1007	14/18367	0.546020701158809	0.809483099979483	HSD17B1	1
GO:0071837	HMG box domain binding	1/1007	14/18367	0.546020701158809	0.809483099979483	GATA3	1
GO:0098599	palmitoyl hydrolase activity	1/1007	14/18367	0.546020701158809	0.809483099979483	LYPLA1	1
GO:0003730	mRNA 3'-UTR binding	11/1007	201/18367	0.546606521527277	0.809483099979483	IGF2BP3/FUS/PUM1/FMR1/RBMS3/LARP4/DHX36/SECISBP2/TIA1/HNRNPU/HNRNPA2B1	11
GO:0008200	ion channel inhibitor activity	2/1007	33/18367	0.546889335606289	0.809483099979483	RASA1/NEDD4	2
GO:0019956	chemokine binding	2/1007	33/18367	0.546889335606289	0.809483099979483	ITGAV/ITGB1	2
GO:0031369	translation initiation factor binding	2/1007	33/18367	0.546889335606289	0.809483099979483	EIF4G1/FMR1	2
GO:0140323	solute:anion antiporter activity	2/1007	33/18367	0.546889335606289	0.809483099979483	SLC26A2/SLC19A1	2
GO:0016597	amino acid binding	3/1007	52/18367	0.548525663718865	0.809483099979483	GLDC/SLC1A3/ASS1	3
GO:0017046	peptide hormone binding	3/1007	52/18367	0.548525663718865	0.809483099979483	SLC40A1/IGF1R/PRLR	3
GO:0001217	DNA-binding transcription repressor activity	17/1007	313/18367	0.551728701927685	0.810823531904239	PEG3/NFE2L3/TFAP2A/TFAP2C/ZFHX3/IRX2/HIC2/ZNF440/AEBP2/PPARG/ZNF439/BHLHE41/NR2F6/GATA3/PRDM2/PURB/YY1	17
GO:0001664	G protein-coupled receptor binding	16/1007	295/18367	0.554582254351055	0.810823531904239	ITGB4/WLS/RNF43/ADRB1/ZNRF3/GNA12/DVL3/HOMER1/S1PR2/NEDD4/RYK/GNAI1/ATP2A2/HSPA1B/VPS35/GNAS	16
GO:0140678	molecular function inhibitor activity	7/1007	128/18367	0.557733110801409	0.810823531904239	RASA1/NEDD4/PURA/ANXA5/BCL2/ANXA3/ANXA2	7
GO:0017069	snRNA binding	3/1007	53/18367	0.561579451852007	0.810823531904239	PRPF8/HEXIM1/HNRNPU	3
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/1007	53/18367	0.561579451852007	0.810823531904239	SLC6A4/SLC5A3/SLC16A1	3
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	4/1007	72/18367	0.561865013802723	0.810823531904239	CYB5A/UQCRC1/NDUFB9/COX6A1	4
GO:0016407	acetyltransferase activity	5/1007	91/18367	0.562951204590082	0.810823531904239	NCOA3/HADHA/HGSNAT/USP22/FASN	5
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/1007	34/18367	0.563230762390047	0.810823531904239	DICER1/AGO2	2
GO:0045505	dynein intermediate chain binding	2/1007	34/18367	0.563230762390047	0.810823531904239	DYNC1H1/DYNLL2	2
GO:0000149	SNARE binding	6/1007	110/18367	0.564416427374152	0.810823531904239	SLC6A4/ABCA1/SYT7/TMED9/UVRAG/GOLGA2	6
GO:0031072	heat shock protein binding	7/1007	129/18367	0.566072683866797	0.810823531904239	HSPA5/DNAJB14/TPR/TFAM/HSPA1B/HDAC2/HSPA9	7
GO:0004953	icosanoid receptor activity	1/1007	15/18367	0.570929825222073	0.810823531904239	PPARG	1
GO:0005452	inorganic anion exchanger activity	1/1007	15/18367	0.570929825222073	0.810823531904239	SLC22A11	1
GO:0008020	G protein-coupled photoreceptor activity	1/1007	15/18367	0.570929825222073	0.810823531904239	OPN3	1
GO:0008559	ABC-type xenobiotic transporter activity	1/1007	15/18367	0.570929825222073	0.810823531904239	ABCB1	1
GO:0010851	cyclase regulator activity	1/1007	15/18367	0.570929825222073	0.810823531904239	GNAS	1
GO:0016846	carbon-sulfur lyase activity	1/1007	15/18367	0.570929825222073	0.810823531904239	MGST3	1
GO:0017136	NAD-dependent histone deacetylase activity	1/1007	15/18367	0.570929825222073	0.810823531904239	HDAC2	1
GO:0019215	intermediate filament binding	1/1007	15/18367	0.570929825222073	0.810823531904239	PKP2	1
GO:0034483	heparan sulfate sulfotransferase activity	1/1007	15/18367	0.570929825222073	0.810823531904239	HS6ST2	1
GO:0043138	3'-5' DNA helicase activity	1/1007	15/18367	0.570929825222073	0.810823531904239	NAV2	1
GO:0045125	bioactive lipid receptor activity	1/1007	15/18367	0.570929825222073	0.810823531904239	S1PR2	1
GO:0051139	metal ion:proton antiporter activity	1/1007	15/18367	0.570929825222073	0.810823531904239	SLC9A1	1
GO:0070742	C2H2 zinc finger domain binding	1/1007	15/18367	0.570929825222073	0.810823531904239	SRRM2	1
GO:1901611	phosphatidylglycerol binding	1/1007	15/18367	0.570929825222073	0.810823531904239	MME	1
GO:0106306	protein serine phosphatase activity	4/1007	73/18367	0.572897157514872	0.811174203508295	CTDSPL/DUSP9/DUSP14/DUSP5	4
GO:0106307	protein threonine phosphatase activity	4/1007	73/18367	0.572897157514872	0.811174203508295	CTDSPL/DUSP9/DUSP14/DUSP5	4
GO:0008374	O-acyltransferase activity	3/1007	54/18367	0.574401461850774	0.812084825375232	LPCAT3/CROT/CPT2	3
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/1007	55/18367	0.586986629635856	0.815020692189311	MGST3/PRDX4/GPX8	3
GO:0030170	pyridoxal phosphate binding	3/1007	55/18367	0.586986629635856	0.815020692189311	GLDC/SPTLC3/PDXDC1	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/1007	16/18367	0.59447350798152	0.815020692189311	PURA	1
GO:0003688	DNA replication origin binding	1/1007	16/18367	0.59447350798152	0.815020692189311	HSPD1	1
GO:0005159	insulin-like growth factor receptor binding	1/1007	16/18367	0.59447350798152	0.815020692189311	GNAS	1
GO:0005521	lamin binding	1/1007	16/18367	0.59447350798152	0.815020692189311	SUN1	1
GO:0005523	tropomyosin binding	1/1007	16/18367	0.59447350798152	0.815020692189311	CALD1	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/1007	16/18367	0.59447350798152	0.815020692189311	SLC22A11	1
GO:0016004	phospholipase activator activity	1/1007	16/18367	0.59447350798152	0.815020692189311	GM2A	1
GO:0016208	AMP binding	1/1007	16/18367	0.59447350798152	0.815020692189311	ACSS1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/1007	16/18367	0.59447350798152	0.815020692189311	PIK3CB	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1007	16/18367	0.59447350798152	0.815020692189311	DICER1	1
GO:0017070	U6 snRNA binding	1/1007	16/18367	0.59447350798152	0.815020692189311	PRPF8	1
GO:0022821	potassium ion antiporter activity	1/1007	16/18367	0.59447350798152	0.815020692189311	SLC9A1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/1007	16/18367	0.59447350798152	0.815020692189311	HDAC2	1
GO:0035173	histone kinase activity	1/1007	16/18367	0.59447350798152	0.815020692189311	BAZ1B	1
GO:0070492	oligosaccharide binding	1/1007	16/18367	0.59447350798152	0.815020692189311	CHID1	1
GO:0000217	DNA secondary structure binding	2/1007	36/18367	0.594628034174174	0.815020692189311	XPC/YY1	2
GO:0015248	sterol transporter activity	2/1007	36/18367	0.594628034174174	0.815020692189311	ABCA1/OSBPL9	2
GO:0042805	actinin binding	2/1007	36/18367	0.594628034174174	0.815020692189311	DAG1/PPARG	2
GO:0043394	proteoglycan binding	2/1007	36/18367	0.594628034174174	0.815020692189311	CTSL/LRP1	2
GO:0045309	protein phosphorylated amino acid binding	3/1007	56/18367	0.59933065873043	0.818329407914488	RASA1/YES1/NEDD4	3
GO:0070279	vitamin B6 binding	3/1007	56/18367	0.59933065873043	0.818329407914488	GLDC/SPTLC3/PDXDC1	3
GO:0003774	cytoskeletal motor activity	6/1007	114/18367	0.599645409192907	0.818329407914488	MYH10/DYNC1H1/MYO7A/MYO1C/KIFC3/MYO6	6
GO:0003724	RNA helicase activity	4/1007	77/18367	0.615408296332915	0.823757955055277	DDX17/DHX36/DDX1/SNRNP200	4
GO:0000400	four-way junction DNA binding	1/1007	17/18367	0.61672652838709	0.823757955055277	YY1	1
GO:0004659	prenyltransferase activity	1/1007	17/18367	0.61672652838709	0.823757955055277	FDFT1	1
GO:0005005	transmembrane-ephrin receptor activity	1/1007	17/18367	0.61672652838709	0.823757955055277	EPHB4	1
GO:0008308	voltage-gated anion channel activity	1/1007	17/18367	0.61672652838709	0.823757955055277	ANO6	1
GO:0008392	arachidonic acid epoxygenase activity	1/1007	17/18367	0.61672652838709	0.823757955055277	CYP2J2	1
GO:0009881	photoreceptor activity	1/1007	17/18367	0.61672652838709	0.823757955055277	OPN3	1
GO:0015108	chloride transmembrane transporter activity	1/1007	17/18367	0.61672652838709	0.823757955055277	SLC26A2	1
GO:0015278	calcium-release channel activity	1/1007	17/18367	0.61672652838709	0.823757955055277	MCOLN3	1
GO:0016854	racemase and epimerase activity	1/1007	17/18367	0.61672652838709	0.823757955055277	GLCE	1
GO:0030169	low-density lipoprotein particle binding	1/1007	17/18367	0.61672652838709	0.823757955055277	COLEC12	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	1/1007	17/18367	0.61672652838709	0.823757955055277	ATP6V1C2	1
GO:0043395	heparan sulfate proteoglycan binding	1/1007	17/18367	0.61672652838709	0.823757955055277	LRP1	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1/1007	17/18367	0.61672652838709	0.823757955055277	ATP6V1C2	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1/1007	17/18367	0.61672652838709	0.823757955055277	ATP6V1C2	1
GO:0008170	N-methyltransferase activity	5/1007	97/18367	0.620109253212389	0.82706560970522	ASH1L/SMYD2/SETD2/NSD1/KMT2C	5
GO:0004520	endodeoxyribonuclease activity	2/1007	38/18367	0.624303649362792	0.82706560970522	RAD50/DICER1	2
GO:0005501	retinoid binding	2/1007	38/18367	0.624303649362792	0.82706560970522	NR2F2/OPN3	2
GO:0019840	isoprenoid binding	2/1007	38/18367	0.624303649362792	0.82706560970522	NR2F2/OPN3	2
GO:0008017	microtubule binding	14/1007	271/18367	0.629551048788997	0.82706560970522	CLIP1/DST/EML4/HOOK2/MACF1/LRPPRC/REEP3/CAPN6/EZR/FMR1/CAMSAP2/KIFC3/GOLGA2/MAP4	14
GO:0008186	ATP-dependent activity, acting on RNA	4/1007	79/18367	0.635647572659853	0.82706560970522	DDX17/DHX36/DDX1/SNRNP200	4
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/1007	18/18367	0.637759573940997	0.82706560970522	HSD17B1	1
GO:0004708	MAP kinase kinase activity	1/1007	18/18367	0.637759573940997	0.82706560970522	MAPK14	1
GO:0005229	intracellular calcium activated chloride channel activity	1/1007	18/18367	0.637759573940997	0.82706560970522	ANO6	1
GO:0008301	DNA binding, bending	1/1007	18/18367	0.637759573940997	0.82706560970522	TFAM	1
GO:0008409	5'-3' exonuclease activity	1/1007	18/18367	0.637759573940997	0.82706560970522	DCP2	1
GO:0016755	aminoacyltransferase activity	1/1007	18/18367	0.637759573940997	0.82706560970522	TGM2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/1007	18/18367	0.637759573940997	0.82706560970522	MARVELD3	1
GO:0050811	GABA receptor binding	1/1007	18/18367	0.637759573940997	0.82706560970522	GABARAPL1	1
GO:0060229	lipase activator activity	1/1007	18/18367	0.637759573940997	0.82706560970522	GM2A	1
GO:0061778	intracellular chloride channel activity	1/1007	18/18367	0.637759573940997	0.82706560970522	ANO6	1
GO:0070122	isopeptidase activity	1/1007	18/18367	0.637759573940997	0.82706560970522	PRPF8	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/1007	39/18367	0.638498158924072	0.82706560970522	POLR2J3/POLR2A	2
GO:0004402	histone acetyltransferase activity	2/1007	39/18367	0.638498158924072	0.82706560970522	NCOA3/USP22	2
GO:0005504	fatty acid binding	2/1007	39/18367	0.638498158924072	0.82706560970522	PPARG/ADH5	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/1007	39/18367	0.638498158924072	0.82706560970522	DLG1/AK3	2
GO:0032451	demethylase activity	2/1007	39/18367	0.638498158924072	0.82706560970522	KDM5B/KDM4B	2
GO:0031492	nucleosomal DNA binding	2/1007	40/18367	0.65226738185027	0.841433845533249	SMARCC1/HDAC2	2
GO:0042287	MHC protein binding	2/1007	40/18367	0.65226738185027	0.841433845533249	BCAP31/VCP	2
GO:0043014	alpha-tubulin binding	2/1007	40/18367	0.65226738185027	0.841433845533249	EML4/SETD2	2
GO:0005003	ephrin receptor activity	1/1007	19/18367	0.657639464346001	0.843746959018066	EPHB4	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/1007	19/18367	0.657639464346001	0.843746959018066	PLEKHA5	1
GO:0016918	retinal binding	1/1007	19/18367	0.657639464346001	0.843746959018066	OPN3	1
GO:0052742	phosphatidylinositol kinase activity	1/1007	19/18367	0.657639464346001	0.843746959018066	PIK3CB	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/1007	41/18367	0.66561523653728	0.852819521813391	NCOA3/USP22	2
GO:0098960	postsynaptic neurotransmitter receptor activity	3/1007	62/18367	0.668176569656239	0.853912837018026	ADRB1/GABRE/GABRA4	3
GO:0015631	tubulin binding	19/1007	375/18367	0.67228406263242	0.853912837018026	DAG1/CLIP1/DST/GJA1/EML4/TPR/HOOK2/MACF1/LRPPRC/GABARAPL1/REEP3/CAPN6/EZR/FMR1/SETD2/CAMSAP2/KIFC3/GOLGA2/MAP4	19
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/1007	20/18367	0.676429362940048	0.853912837018026	HNRNPU	1
GO:0001972	retinoic acid binding	1/1007	20/18367	0.676429362940048	0.853912837018026	NR2F2	1
GO:0004551	nucleotide diphosphatase activity	1/1007	20/18367	0.676429362940048	0.853912837018026	NUDT4	1
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	1/1007	20/18367	0.676429362940048	0.853912837018026	ATP6V1C2	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/1007	20/18367	0.676429362940048	0.853912837018026	GLDC	1
GO:0031681	G-protein beta-subunit binding	1/1007	20/18367	0.676429362940048	0.853912837018026	GNG12	1
GO:0050145	nucleoside monophosphate kinase activity	1/1007	20/18367	0.676429362940048	0.853912837018026	DLG1	1
GO:0061608	nuclear import signal receptor activity	1/1007	20/18367	0.676429362940048	0.853912837018026	TNPO1	1
GO:0097001	ceramide binding	1/1007	20/18367	0.676429362940048	0.853912837018026	PLEKHA8	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	11/1007	222/18367	0.678088006861101	0.854862286724623	NCOA3/TGM2/HADHA/LPCAT3/CROT/SPTLC3/CPT2/ZDHHC17/HGSNAT/USP22/FASN	11
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6/1007	124/18367	0.680496158153888	0.856752839972118	IDH1/HADHA/HSD17B1/LDHB/ADH5/FASN	6
GO:0001540	amyloid-beta binding	4/1007	84/18367	0.683142425922709	0.857794018169261	LRPAP1/LRP1/CLSTN1/FZD5	4
GO:0008135	translation factor activity, RNA binding	4/1007	84/18367	0.683142425922709	0.857794018169261	EIF3A/EIF4G1/AGO2/DENR	4
GO:0016874	ligase activity	8/1007	165/18367	0.689278733705731	0.857955707625678	ACSS1/SLC27A2/IARS2/RIMKLB/MDM2/ACSF2/ASS1/ACSL3	8
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	2/1007	43/18367	0.691066651852057	0.857955707625678	MICAL3/SQLE	2
GO:0016790	thiolester hydrolase activity	2/1007	43/18367	0.691066651852057	0.857955707625678	FASN/LYPLA1	2
GO:0034062	5'-3' RNA polymerase activity	2/1007	43/18367	0.691066651852057	0.857955707625678	POLR2J3/POLR2A	2
GO:0097747	RNA polymerase activity	2/1007	43/18367	0.691066651852057	0.857955707625678	POLR2J3/POLR2A	2
GO:0001614	purinergic nucleotide receptor activity	1/1007	21/18367	0.694188976583661	0.857955707625678	P2RX4	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/1007	21/18367	0.694188976583661	0.857955707625678	LPCAT3	1
GO:0004407	histone deacetylase activity	1/1007	21/18367	0.694188976583661	0.857955707625678	HDAC2	1
GO:0008391	arachidonic acid monooxygenase activity	1/1007	21/18367	0.694188976583661	0.857955707625678	CYP2J2	1
GO:0016502	nucleotide receptor activity	1/1007	21/18367	0.694188976583661	0.857955707625678	P2RX4	1
GO:0051428	peptide hormone receptor binding	1/1007	21/18367	0.694188976583661	0.857955707625678	GNAS	1
GO:0140416	transcription regulator inhibitor activity	1/1007	21/18367	0.694188976583661	0.857955707625678	PURA	1
GO:0030145	manganese ion binding	3/1007	65/18367	0.699193937468937	0.863010318106292	EXTL2/B4GALT1/DCP2	3
GO:0016209	antioxidant activity	4/1007	86/18367	0.700875798694807	0.863955396299611	MGST3/PRDX4/GPX8/SOD3	4
GO:0001784	phosphotyrosine residue binding	2/1007	44/18367	0.703181881401632	0.864537828111784	RASA1/YES1	2
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	2/1007	44/18367	0.703181881401632	0.864537828111784	GABRE/GABRA4	2
GO:0015106	bicarbonate transmembrane transporter activity	1/1007	22/18367	0.710974744630116	0.86509572153058	SLC26A2	1
GO:0017075	syntaxin-1 binding	1/1007	22/18367	0.710974744630116	0.86509572153058	SLC6A4	1
GO:0030742	GTP-dependent protein binding	1/1007	22/18367	0.710974744630116	0.86509572153058	EEA1	1
GO:0033558	protein deacetylase activity	1/1007	22/18367	0.710974744630116	0.86509572153058	HDAC2	1
GO:0033691	sialic acid binding	1/1007	22/18367	0.710974744630116	0.86509572153058	SIGLEC6	1
GO:0050321	tau-protein kinase activity	1/1007	22/18367	0.710974744630116	0.86509572153058	GSK3B	1
GO:0070182	DNA polymerase binding	1/1007	22/18367	0.710974744630116	0.86509572153058	HSP90AA1	1
GO:0120020	cholesterol transfer activity	1/1007	22/18367	0.710974744630116	0.86509572153058	ABCA1	1
GO:0090079	translation regulator activity, nucleic acid binding	5/1007	108/18367	0.712481860045034	0.865812363431014	EIF3A/EIF4G1/PURA/AGO2/DENR	5
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/1007	45/18367	0.714898897370809	0.866516272777215	DICER1/AGO2	2
GO:0048156	tau protein binding	2/1007	45/18367	0.714898897370809	0.866516272777215	HSP90AA1/GSK3B	2
GO:0042578	phosphoric ester hydrolase activity	18/1007	366/18367	0.716853808858544	0.867770400197185	DLG1/PDIA3/PTPN14/CTDSPL/PLPP3/CAMK2G/DUSP9/SMPDL3A/PTP4A1/PTPN1/PTPRM/PPP4R1/DUSP14/SGPP1/PTPRA/TNS3/PDP2/DUSP5	18
GO:0016746	acyltransferase activity	12/1007	250/18367	0.722957062062233	0.868941415134115	NCOA3/TGM2/HADHA/LPCAT3/CROT/SPTLC3/CPT2/ZDHHC17/HGSNAT/KMT2C/USP22/FASN	12
GO:0008236	serine-type peptidase activity	9/1007	191/18367	0.726138742541879	0.868941415134115	DPP4/CTSV/PRSS8/MBTPS1/CPD/PRSS12/MMP14/ST14/PCSK7	9
GO:0140296	general transcription initiation factor binding	2/1007	46/18367	0.726224899456256	0.868941415134115	BDP1/HNRNPU	2
GO:0005212	structural constituent of eye lens	1/1007	23/18367	0.726840017574105	0.868941415134115	CRYBG3	1
GO:0015299	solute:proton antiporter activity	1/1007	23/18367	0.726840017574105	0.868941415134115	SLC9A1	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/1007	23/18367	0.726840017574105	0.868941415134115	CDO1	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/1007	23/18367	0.726840017574105	0.868941415134115	LPCAT3	1
GO:0071617	lysophospholipid acyltransferase activity	1/1007	23/18367	0.726840017574105	0.868941415134115	LPCAT3	1
GO:0120015	sterol transfer activity	1/1007	23/18367	0.726840017574105	0.868941415134115	ABCA1	1
GO:0008080	N-acetyltransferase activity	3/1007	68/18367	0.727957283092206	0.868941415134115	NCOA3/HGSNAT/USP22	3
GO:0016782	transferase activity, transferring sulphur-containing groups	3/1007	68/18367	0.727957283092206	0.868941415134115	TPST2/HS6ST2/MOCS2	3
GO:0004521	endoribonuclease activity	3/1007	69/18367	0.737052296351667	0.876629847197267	SND1/DICER1/AGO2	3
GO:0001965	G-protein alpha-subunit binding	1/1007	24/18367	0.74183522594212	0.876629847197267	GPSM2	1
GO:0003707	steroid hormone receptor activity	1/1007	24/18367	0.74183522594212	0.876629847197267	ESRRG	1
GO:0004622	lysophospholipase activity	1/1007	24/18367	0.74183522594212	0.876629847197267	LYPLA1	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/1007	24/18367	0.74183522594212	0.876629847197267	CDO1	1
GO:0043274	phospholipase binding	1/1007	24/18367	0.74183522594212	0.876629847197267	PLA2R1	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/1007	24/18367	0.74183522594212	0.876629847197267	BMP7	1
GO:0120014	phospholipid transfer activity	1/1007	24/18367	0.74183522594212	0.876629847197267	PLEKHA8	1
GO:0004252	serine-type endopeptidase activity	8/1007	174/18367	0.74403194084078	0.878125306899694	DPP4/CTSV/PRSS8/MBTPS1/PRSS12/MMP14/ST14/PCSK7	8
GO:0004857	enzyme inhibitor activity	3/1007	70/18367	0.745904868113306	0.878137691174591	ANXA5/ANXA3/ANXA2	3
GO:0004860	protein kinase inhibitor activity	3/1007	70/18367	0.745904868113306	0.878137691174591	PKIB/CDKN1C/HEXIM1	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/1007	48/18367	0.747734634021981	0.87855684513576	RIMKLB/ASS1	2
GO:0017171	serine hydrolase activity	9/1007	195/18367	0.748124227618256	0.87855684513576	DPP4/CTSV/PRSS8/MBTPS1/CPD/PRSS12/MMP14/ST14/PCSK7	9
GO:0008327	methyl-CpG binding	1/1007	25/18367	0.756008039957073	0.884510647245062	DNMT1	1
GO:0030247	polysaccharide binding	1/1007	25/18367	0.756008039957073	0.884510647245062	AGL	1
GO:0035035	histone acetyltransferase binding	1/1007	25/18367	0.756008039957073	0.884510647245062	GLI3	1
GO:0034212	peptide N-acetyltransferase activity	2/1007	49/18367	0.757934546385359	0.885665771055011	NCOA3/USP22	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	6/1007	136/18367	0.762439311239345	0.888860142327468	IDH1/HADHA/HSD17B1/LDHB/ADH5/FASN	6
GO:0000049	tRNA binding	3/1007	72/18367	0.7628939672029	0.888860142327468	IARS2/EIF2AK4/NEMF	3
GO:0016410	N-acyltransferase activity	4/1007	94/18367	0.764588198118932	0.888860142327468	NCOA3/TGM2/HGSNAT/USP22	4
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/1007	50/18367	0.767775689721845	0.888860142327468	TLR3/MAN2A1	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/1007	26/18367	0.769403520480638	0.888860142327468	ZDHHC17	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/1007	26/18367	0.769403520480638	0.888860142327468	ZDHHC17	1
GO:0038187	pattern recognition receptor activity	1/1007	26/18367	0.769403520480638	0.888860142327468	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/1007	26/18367	0.769403520480638	0.888860142327468	SLC26A2	1
GO:0097602	cullin family protein binding	1/1007	26/18367	0.769403520480638	0.888860142327468	DDB1	1
GO:0005230	extracellular ligand-gated ion channel activity	3/1007	73/18367	0.771036687618101	0.888860142327468	GABRE/P2RX4/GABRA4	3
GO:0033293	monocarboxylic acid binding	3/1007	73/18367	0.771036687618101	0.888860142327468	NR2F2/PPARG/ADH5	3
GO:0000287	magnesium ion binding	10/1007	221/18367	0.776690780741544	0.893923150050821	ATP10D/IDH1/RPS6KA5/STK26/WEE1/AASDHPPT/GNAI1/DHX36/RP2/CDC42BPB	10
GO:0019210	kinase inhibitor activity	3/1007	74/18367	0.778949308416157	0.893923150050821	PKIB/CDKN1C/HEXIM1	3
GO:0004683	calmodulin-dependent protein kinase activity	1/1007	27/18367	0.78206426170936	0.893923150050821	CAMK2G	1
GO:0008139	nuclear localization sequence binding	1/1007	27/18367	0.78206426170936	0.893923150050821	TNPO1	1
GO:0015491	cation:cation antiporter activity	1/1007	27/18367	0.78206426170936	0.893923150050821	SLC9A1	1
GO:0016866	intramolecular transferase activity	1/1007	27/18367	0.78206426170936	0.893923150050821	CYP2J2	1
GO:0023026	MHC class II protein complex binding	1/1007	27/18367	0.78206426170936	0.893923150050821	HSP90AA1	1
GO:0008146	sulfotransferase activity	2/1007	52/18367	0.786416339995969	0.896973597179631	TPST2/HS6ST2	2
GO:0019003	GDP binding	3/1007	75/18367	0.786635381619889	0.896973597179631	KRAS/RAB31/GNAI1	3
GO:0003953	NAD+ nucleosidase activity	1/1007	28/18367	0.79403052607461	0.902133477214888	TLR3	1
GO:0004629	phospholipase C activity	1/1007	28/18367	0.79403052607461	0.902133477214888	PDIA3	1
GO:0017056	structural constituent of nuclear pore	1/1007	28/18367	0.79403052607461	0.902133477214888	TPR	1
GO:0050661	NADP binding	2/1007	53/18367	0.795233472864359	0.902412954164971	IDH1/HSD17B1	2
GO:0005496	steroid binding	4/1007	100/18367	0.805036910223923	0.90950415638433	ABCA1/ESRRG/HSD17B1/OSBPL9	4
GO:0004181	metallocarboxypeptidase activity	1/1007	29/18367	0.805340371771914	0.90950415638433	CPD	1
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/1007	29/18367	0.805340371771914	0.90950415638433	P2RX4	1
GO:0046625	sphingolipid binding	1/1007	29/18367	0.805340371771914	0.90950415638433	PLEKHA8	1
GO:0140375	immune receptor activity	6/1007	144/18367	0.807766504342899	0.910746386099599	CSF3R/CSF2RA/PRLR/IL10RB/IL6ST/LIFR	6
GO:0030971	receptor tyrosine kinase binding	3/1007	78/18367	0.808371924883738	0.910746386099599	PTPN14/EIF3A/PTPN1	3
GO:0005217	intracellular ligand-gated ion channel activity	1/1007	30/18367	0.816029773322011	0.917182450825574	MCOLN3	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/1007	30/18367	0.816029773322011	0.917182450825574	HSD17B1	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/1007	56/18367	0.819779050958704	0.920299577445307	BIRC6/CAST	2
GO:0004527	exonuclease activity	3/1007	80/18367	0.821801120636754	0.921472600190795	RAD50/DCP2/DDX1	3
GO:0008157	protein phosphatase 1 binding	1/1007	31/18367	0.826132735544007	0.924131873805455	PPP1R9A	1
GO:0016411	acylglycerol O-acyltransferase activity	1/1007	31/18367	0.826132735544007	0.924131873805455	LPCAT3	1
GO:0004536	deoxyribonuclease activity	2/1007	57/18367	0.827355380886373	0.92440299072968	RAD50/DICER1	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	2/1007	58/18367	0.834643726633919	0.927114778148438	SMS/FDFT1	2
GO:0001222	transcription corepressor binding	1/1007	32/18367	0.835681401300289	0.927114778148438	SUZ12	1
GO:0008175	tRNA methyltransferase activity	1/1007	32/18367	0.835681401300289	0.927114778148438	TARBP1	1
GO:0030332	cyclin binding	1/1007	32/18367	0.835681401300289	0.927114778148438	CDK6	1
GO:0048019	receptor antagonist activity	1/1007	32/18367	0.835681401300289	0.927114778148438	LRPAP1	1
GO:0071889	14-3-3 protein binding	1/1007	32/18367	0.835681401300289	0.927114778148438	TMCC3	1
GO:0005506	iron ion binding	6/1007	151/18367	0.841630745803131	0.932004307347804	CALR/TET2/CDO1/CYP2J2/P3H2/P3H1	6
GO:0004519	endonuclease activity	5/1007	129/18367	0.842065397518907	0.932004307347804	N4BP2/SND1/RAD50/DICER1/AGO2	5
GO:0001530	lipopolysaccharide binding	1/1007	33/18367	0.844706153353227	0.932737590880671	HSPD1	1
GO:0051427	hormone receptor binding	1/1007	33/18367	0.844706153353227	0.932737590880671	GNAS	1
GO:0022824	transmitter-gated ion channel activity	2/1007	60/18367	0.848391436415837	0.933527566557916	GABRE/GABRA4	2
GO:0022835	transmitter-gated channel activity	2/1007	60/18367	0.848391436415837	0.933527566557916	GABRE/GABRA4	2
GO:0032934	sterol binding	2/1007	60/18367	0.848391436415837	0.933527566557916	ABCA1/OSBPL9	2
GO:0016229	steroid dehydrogenase activity	1/1007	34/18367	0.853235710655141	0.936672031603956	HSD17B1	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/1007	34/18367	0.853235710655141	0.936672031603956	IGF1R	1
GO:0015298	solute:cation antiporter activity	1/1007	35/18367	0.861297219375496	0.944422416129178	SLC9A1	1
GO:0023023	MHC protein complex binding	1/1007	36/18367	0.868916338952677	0.950566250153566	HSP90AA1	1
GO:0042605	peptide antigen binding	1/1007	36/18367	0.868916338952677	0.950566250153566	DHCR24	1
GO:0030551	cyclic nucleotide binding	1/1007	37/18367	0.876117323442048	0.95622527315492	SLC19A1	1
GO:0071855	neuropeptide receptor binding	1/1007	37/18367	0.876117323442048	0.95622527315492	GNAS	1
GO:0008173	RNA methyltransferase activity	2/1007	65/18367	0.878321196533171	0.957522414255237	TARBP1/CMTR1	2
GO:0008395	steroid hydroxylase activity	1/1007	38/18367	0.882923098417163	0.95795260819798	CYP2J2	1
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	1/1007	38/18367	0.882923098417163	0.95795260819798	DCP2	1
GO:0019213	deacetylase activity	1/1007	38/18367	0.882923098417163	0.95795260819798	HDAC2	1
GO:0005525	GTP binding	16/1007	377/18367	0.884591766928885	0.95795260819798	TGM2/RHOBTB3/GNA12/ARHGAP5/ARL15/RAB6A/KRAS/RAB31/GNAI1/RANBP17/RP2/RND3/LSG1/AK3/ARL1/GNAS	16
GO:0019001	guanyl nucleotide binding	17/1007	398/18367	0.885064680151369	0.95795260819798	TGM2/RHOBTB3/SLC19A1/GNA12/ARHGAP5/ARL15/RAB6A/KRAS/RAB31/GNAI1/RANBP17/RP2/RND3/LSG1/AK3/ARL1/GNAS	17
GO:0032561	guanyl ribonucleotide binding	17/1007	398/18367	0.885064680151369	0.95795260819798	TGM2/RHOBTB3/SLC19A1/GNA12/ARHGAP5/ARL15/RAB6A/KRAS/RAB31/GNAI1/RANBP17/RP2/RND3/LSG1/AK3/ARL1/GNAS	17
GO:0004540	ribonuclease activity	4/1007	116/18367	0.885826802066425	0.95795260819798	SND1/DCP2/DICER1/AGO2	4
GO:0003925	G protein activity	1/1007	40/18367	0.895434511918691	0.965022565416372	KRAS	1
GO:0004532	exoribonuclease activity	1/1007	40/18367	0.895434511918691	0.965022565416372	DCP2	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/1007	40/18367	0.895434511918691	0.965022565416372	CYP2J2	1
GO:0003777	microtubule motor activity	2/1007	69/18367	0.898230762117304	0.966931060133125	DYNC1H1/KIFC3	2
GO:0004812	aminoacyl-tRNA ligase activity	1/1007	41/18367	0.901179993803227	0.96789605256998	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/1007	41/18367	0.901179993803227	0.96789605256998	IARS2	1
GO:0001046	core promoter sequence-specific DNA binding	1/1007	42/18367	0.906610079268694	0.968212576457791	AGO2	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1/1007	42/18367	0.906610079268694	0.968212576457791	NDUFB9	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/1007	42/18367	0.906610079268694	0.968212576457791	ACO1	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/1007	71/18367	0.907006389808308	0.968212576457791	TGM2/HDAC2	2
GO:0052689	carboxylic ester hydrolase activity	5/1007	147/18367	0.910844615517685	0.968212576457791	IARS2/PGAP1/APMAP/PON2/LYPLA1	5
GO:0004180	carboxypeptidase activity	1/1007	43/18367	0.911742065635757	0.968212576457791	CPD	1
GO:0005246	calcium channel regulator activity	1/1007	43/18367	0.911742065635757	0.968212576457791	TSPAN13	1
GO:0030544	Hsp70 protein binding	1/1007	43/18367	0.911742065635757	0.968212576457791	DNAJB14	1
GO:0030547	signaling receptor inhibitor activity	1/1007	43/18367	0.911742065635757	0.968212576457791	LRPAP1	1
GO:0050136	NADH dehydrogenase (quinone) activity	1/1007	43/18367	0.911742065635757	0.968212576457791	NDUFB9	1
GO:0046982	protein heterodimerization activity	13/1007	328/18367	0.915769338642936	0.970085904867723	TENM3/ADRB1/ITGB1/P4HB/ERBB3/FMR1/TOP2B/JAM3/HEXA/BHLHE41/BCL2/EXT2/ATF6	13
GO:0046906	tetrapyrrole binding	5/1007	149/18367	0.916571561135233	0.970085904867723	MTR/EIF2AK1/CYP2J2/CYB5A/STC2	5
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/1007	44/18367	0.916592302478411	0.970085904867723	MAPK14	1
GO:0003954	NADH dehydrogenase activity	1/1007	45/18367	0.921176243503583	0.971665769154227	NDUFB9	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/1007	45/18367	0.921176243503583	0.971665769154227	NDUFB9	1
GO:0005245	voltage-gated calcium channel activity	1/1007	45/18367	0.921176243503583	0.971665769154227	ITGAV	1
GO:0004497	monooxygenase activity	3/1007	102/18367	0.923495521929193	0.973023773384614	CYP2J2/MICAL3/SQLE	3
GO:0003924	GTPase activity	13/1007	337/18367	0.931900324492504	0.980783488835303	RASA1/RHOBTB3/GNA12/ARHGAP5/ARL15/RAB6A/KRAS/RAB31/GNAI1/RND3/LSG1/ARL1/GNAS	13
GO:0019887	protein kinase regulator activity	7/1007	204/18367	0.935099861919014	0.982640841945464	CD24/ERBB3/CCND1/PKIB/KIDINS220/CDKN1C/HEXIM1	7
GO:0016779	nucleotidyltransferase activity	4/1007	132/18367	0.935749179286348	0.982640841945464	CDS1/UGP2/POLR2J3/POLR2A	4
GO:0015485	cholesterol binding	1/1007	50/18367	0.940585639656151	0.986620976858455	ABCA1	1
GO:0008227	G protein-coupled amine receptor activity	1/1007	51/18367	0.94385201847726	0.988947170471174	ADRB1	1
GO:0004518	nuclease activity	7/1007	210/18367	0.946040279306171	0.990006087700361	N4BP2/SND1/RAD50/DCP2/DICER1/DDX1/AGO2	7
GO:0030594	neurotransmitter receptor activity	3/1007	111/18367	0.946962344756867	0.990006087700361	ADRB1/GABRE/GABRA4	3
GO:0015267	channel activity	19/1007	480/18367	0.949553456877931	0.99055242738	ITGAV/GJA1/GABRE/CLDN4/GJA5/FXYD3/ANO6/TMEM150C/TMC5/KCNN4/MCOLN3/TRPV6/P2RX4/GABRA4/TRPM7/TMEM63A/BCL2/CUL5/ANXA2	19
GO:0020037	heme binding	4/1007	139/18367	0.950565859791988	0.99055242738	EIF2AK1/CYP2J2/CYB5A/STC2	4
GO:0022803	passive transmembrane transporter activity	19/1007	481/18367	0.950636210794168	0.99055242738	ITGAV/GJA1/GABRE/CLDN4/GJA5/FXYD3/ANO6/TMEM150C/TMC5/KCNN4/MCOLN3/TRPV6/P2RX4/GABRA4/TRPM7/TMEM63A/BCL2/CUL5/ANXA2	19
GO:0008408	3'-5' exonuclease activity	1/1007	54/18367	0.952613564795265	0.991517209273659	RAD50	1
GO:0015276	ligand-gated ion channel activity	4/1007	143/18367	0.957554046196175	0.993431889886387	GABRE/MCOLN3/P2RX4/GABRA4	4
GO:0022834	ligand-gated channel activity	4/1007	143/18367	0.957554046196175	0.993431889886387	GABRE/MCOLN3/P2RX4/GABRA4	4
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/1007	88/18367	0.957613560876698	0.993431889886387	CYB5R1/NDUFB9	2
GO:0008081	phosphoric diester hydrolase activity	2/1007	89/18367	0.959565803438337	0.993730573476953	PDIA3/SMPDL3A	2
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/1007	57/18367	0.9600090693929	0.993730573476953	NDUFB9	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/1007	59/18367	0.964287006316197	0.997064305872998	DCP2	1
GO:0005216	ion channel activity	16/1007	432/18367	0.966180368430807	0.997927806604875	ITGAV/GABRE/CLDN4/FXYD3/ANO6/TMEM150C/TMC5/KCNN4/MCOLN3/TRPV6/P2RX4/GABRA4/TRPM7/TMEM63A/CUL5/ANXA2	16
GO:0019207	kinase regulator activity	7/1007	233/18367	0.974303415704856	0.999966860481145	CD24/ERBB3/CCND1/PKIB/KIDINS220/CDKN1C/HEXIM1	7
GO:0030295	protein kinase activator activity	2/1007	101/18367	0.977191641302901	0.999966860481145	CD24/ERBB3	2
GO:0019843	rRNA binding	1/1007	68/18367	0.978539034468275	0.999966860481145	MDM2	1
GO:0051536	iron-sulfur cluster binding	1/1007	68/18367	0.978539034468275	0.999966860481145	ACO1	1
GO:0051540	metal cluster binding	1/1007	68/18367	0.978539034468275	0.999966860481145	ACO1	1
GO:0004620	phospholipase activity	2/1007	104/18367	0.980268422337284	0.999966860481145	PDIA3/LYPLA1	2
GO:0140098	catalytic activity, acting on RNA	13/1007	386/18367	0.980924156127105	0.999966860481145	IARS2/SND1/DDX17/POLR2J3/DCP2/DICER1/TARBP1/DHX36/DDX1/AGO2/SNRNP200/CMTR1/POLR2A	13
GO:0019209	kinase activator activity	2/1007	107/18367	0.982941093163231	0.999966860481145	CD24/ERBB3	2
GO:0005126	cytokine receptor binding	8/1007	271/18367	0.983423066504113	0.999966860481145	PRLR/TGFBR3/IL6ST/FERMT2/CD2AP/TGFBR1/GATA3/LIFR	8
GO:0099094	ligand-gated cation channel activity	2/1007	113/18367	0.987272454759453	0.999966860481145	MCOLN3/P2RX4	2
GO:0008528	G protein-coupled peptide receptor activity	3/1007	147/18367	0.988758701328465	0.999966860481145	LGR5/LGR4/S1PR2	3
GO:0005261	cation channel activity	10/1007	335/18367	0.989663491722291	0.999966860481145	ITGAV/ANO6/KCNN4/MCOLN3/TRPV6/P2RX4/TRPM7/TMEM63A/CUL5/ANXA2	10
GO:0022836	gated channel activity	10/1007	340/18367	0.991192905708294	0.999966860481145	ITGAV/GABRE/ANO6/TMEM150C/TMC5/KCNN4/MCOLN3/P2RX4/GABRA4/TMEM63A	10
GO:0001653	peptide receptor activity	3/1007	153/18367	0.991412785413002	0.999966860481145	LGR5/LGR4/S1PR2	3
GO:0005179	hormone activity	2/1007	122/18367	0.991831603349566	0.999966860481145	FBN1/STC2	2
GO:0015079	potassium ion transmembrane transporter activity	3/1007	155/18367	0.992154581472469	0.999966860481145	KCNN4/SLC12A9/SLC9A1	3
GO:0140101	catalytic activity, acting on a tRNA	2/1007	124/18367	0.99260284435676	0.999966860481145	IARS2/TARBP1	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/1007	125/18367	0.992961277595209	0.999966860481145	TGM2/HDAC2	2
GO:0043178	alcohol binding	1/1007	89/18367	0.993466678113915	0.999966860481145	ABCA1	1
GO:0016298	lipase activity	2/1007	129/18367	0.99423253971518	0.999966860481145	PDIA3/LYPLA1	2
GO:0008083	growth factor activity	3/1007	162/18367	0.994293581019663	0.999966860481145	EFEMP1/BMP7/RABEP1	3
GO:0030546	signaling receptor activator activity	15/1007	495/18367	0.996804672108952	0.999966860481145	FBN1/APP/EFEMP1/SEMA6A/SEMA6D/BMP7/DPP4/LRPAP1/FAM3B/SEMA3F/CMTM8/FAM3C/SEMA4B/STC2/RABEP1	15
GO:0048018	receptor ligand activity	14/1007	487/18367	0.998084203632073	0.999966860481145	FBN1/EFEMP1/SEMA6A/SEMA6D/BMP7/DPP4/LRPAP1/FAM3B/SEMA3F/CMTM8/FAM3C/SEMA4B/STC2/RABEP1	14
GO:0005267	potassium channel activity	1/1007	121/18367	0.998936131246502	0.999966860481145	KCNN4	1
GO:0005125	cytokine activity	4/1007	235/18367	0.999125863870321	0.999966860481145	BMP7/FAM3B/CMTM8/FAM3C	4
GO:0022843	voltage-gated cation channel activity	1/1007	143/18367	0.999695109848246	0.999966860481145	ITGAV	1
GO:0005244	voltage-gated ion channel activity	2/1007	201/18367	0.999856423625257	0.999966860481145	ITGAV/ANO6	2
GO:0022832	voltage-gated channel activity	2/1007	201/18367	0.999856423625257	0.999966860481145	ITGAV/ANO6	2
GO:0003823	antigen binding	1/1007	171/18367	0.999937998582923	0.999966860481145	DHCR24	1
GO:0003735	structural constituent of ribosome	1/1007	182/18367	0.999966860481145	0.999966860481145	RPS21	1