ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0007163 establishment or maintenance of cell polarity 37/998 218/18722 3.52903612421496e-10 1.17425186853523e-06 KANK1/DST/DLG5/ITGB1/GJA1/SPINT2/DLG1/AMOT/RHOBTB3/MPP7/FRMD4A/FERMT1/PARD6B/SLC9A1/DOCK8/FAT1/FRMD4B/PRKCI/CYTH3/PARD3/WEE1/AMOTL1/HSP90AA1/JAM3/MAP7/PTK2/GATA3/MAP4/RND3/ARFGEF1/GSK3B/FLOT2/GPSM2/OPHN1/CDC42BPB/CTNNA1/LMNA 37 GO:0045216 cell-cell junction organization 35/998 200/18722 4.49818758297351e-10 1.17425186853523e-06 DSP/CDH1/SVEP1/PERP/DLG5/GJA1/DLG1/CTNND1/CLDN4/GJA5/DSG2/MPP7/PARD6B/FERMT2/MARVELD3/TJP1/EPB41L3/PRKCI/LSR/TGFBR1/PARD3/JAM3/PKN2/GRHL1/CTNNB1/PKP2/FZD5/MYO1C/KIFC3/CLDN7/RDX/PLEC/OCLN/MARVELD2/CTNNA1 35 GO:0010232 vascular transport 22/998 88/18722 8.12493337563853e-10 1.22711246123166e-06 LRP2/SLC2A1/TFRC/GJA1/SLC38A1/SLC5A3/LRP1/SLC16A12/SLC19A1/ATP2B4/SLC13A3/SLC16A1/SLC16A2/SLC44A1/SLC1A5/SLC7A2/SLC1A3/SLC5A6/SLC22A5/SLC38A2/ABCB1/SLC29A1 22 GO:0001763 morphogenesis of a branching structure 34/998 196/18722 1.01240324686901e-09 1.22711246123166e-06 MET/SPINT1/DAG1/MAGED1/NRP1/LAMA5/BMP7/DLG5/LGR4/SPINT2/PBX1/DLG1/LRP5/TGM2/YAP1/RERE/TACSTD2/GLI3/KDM5B/TP63/RTN4/SETD2/KRAS/FGFR2/CTNNB1/FZD5/MMP14/DDR1/PLXNA1/BCL2/ST14/BTBD7/GPC3/MAP3K13 34 GO:0061458 reproductive system development 55/998 427/18722 1.17516994946529e-09 1.22711246123166e-06 LRP2/SPINT1/MME/ADGRG1/BMP7/ITGB8/SERPINF1/HSPA5/GJA1/LGR4/SPINT2/NR2F2/DLG1/ADAMTS1/RHOBTB3/IDH1/CTSV/ZFX/TFAP2C/ASH1L/SF1/HECTD1/GLI3/KDM5B/ATRX/MAP3K4/BPTF/TLR3/CCND1/PRDX4/TP63/BSG/DHCR24/BIRC6/TGFBR1/SETD2/PPARG/MAPK14/FGFR2/ARID5B/PLEKHA1/CTNNB1/FZD5/MMP14/PTK2/SMARCC1/GATA3/BCL2/ST14/STC2/PLEKHA5/NIPBL/TMF1/CTNNA1/PHLDA2 55 GO:0048608 reproductive structure development 54/998 424/18722 2.50468804885539e-09 2.17949605051233e-06 LRP2/SPINT1/MME/ADGRG1/BMP7/ITGB8/SERPINF1/HSPA5/GJA1/LGR4/SPINT2/NR2F2/DLG1/ADAMTS1/RHOBTB3/IDH1/CTSV/ZFX/TFAP2C/ASH1L/SF1/HECTD1/GLI3/KDM5B/ATRX/MAP3K4/BPTF/TLR3/CCND1/PRDX4/TP63/BSG/DHCR24/BIRC6/TGFBR1/SETD2/PPARG/MAPK14/FGFR2/ARID5B/PLEKHA1/CTNNB1/FZD5/MMP14/PTK2/SMARCC1/GATA3/BCL2/ST14/STC2/NIPBL/TMF1/CTNNA1/PHLDA2 54 GO:0150104 transport across blood-brain barrier 21/998 87/18722 3.90748092162394e-09 2.91442255597122e-06 LRP2/SLC2A1/TFRC/SLC38A1/SLC5A3/LRP1/SLC16A12/SLC19A1/ATP2B4/SLC13A3/SLC16A1/SLC16A2/SLC44A1/SLC1A5/SLC7A2/SLC1A3/SLC5A6/SLC22A5/SLC38A2/ABCB1/SLC29A1 21 GO:0034329 cell junction assembly 53/998 420/18722 4.87137177087272e-09 3.17917900196581e-06 ITGA6/APP/CDH1/ITGB4/LAMC1/NRP1/DST/DLG5/GJA1/DLG1/CTNND1/CLDN4/GJA5/LRP1/SLK/MPP7/PPP1R9A/OBSL1/PLXNB1/PARD6B/NRCAM/SLC9A1/FERMT2/MACF1/MARVELD3/TJP1/EIF4G1/EPB41L3/TPBG/LSR/SORBS1/PARD3/CLSTN1/JAM3/PKN2/RYK/CTNNB1/PKP2/FZD5/MYO1C/MMP14/CLDN7/PTK2/BCL2/PLEC/OCLN/PTPRA/OPHN1/PHLDB2/SHANK2/MARVELD2/CTNNA1/VPS35 53 GO:0048193 Golgi vesicle transport 42/998 296/18722 6.54180653819121e-09 3.79497465954404e-06 GOLGA4/LMAN1/ANK3/PGAP1/TMED4/TRIP11/CUX1/PLPP3/ERGIC3/EXOC1/SEC31A/CREB3L2/CLN3/TMED9/MACF1/RAB6A/ERGIC2/VPS13A/PRKCI/CYTH3/COPB1/MIA3/BCAP31/SCAMP2/UVRAG/VCP/RAB31/GCC2/USO1/GOPC/RP2/GOLGA2/SPTBN1/ACSL3/RABEP1/COPB2/LYPLA1/ARL1/TMED1/TFG/KDELR1/KRT18 42 GO:0034976 response to endoplasmic reticulum stress 38/998 256/18722 9.90079532313727e-09 5.16920523820997e-06 HSP90B1/HSPA5/P4HB/PDIA3/CCDC47/CALR/CANX/PDIA4/UBXN4/USP25/LPCAT3/ERLEC1/DNAJB14/CREB3L2/CCND1/STT3B/UBE4B/MBTPS1/UFL1/ERP29/EIF4G1/TMTC3/PTPN1/BCAP31/EIF2AK4/VCP/SEL1L/EDEM3/BCL2/ATP2A2/SERINC3/GSK3B/ATF6/PMAIP1/UBE2G2/NFE2L2/USP14/TMEM259 38 GO:0001667 ameboidal-type cell migration 56/998 475/18722 2.06148324170303e-08 9.7845490953923e-06 MET/NRP2/ITGB4/SEMA6A/SEMA6D/KANK1/NRP1/LAMA5/BMP7/DPP4/SERPINF1/ITGB1/GJA1/NR2F2/NF1/LRP5/AMOT/CALR/EPHB4/PLPP3/GNA12/ATP2B4/TACSTD2/FOLR1/ISL1/FSTL1/FERMT1/EFNA1/WASF2/CLN3/MACF1/MARVELD3/RTN4/SEMA3F/TPBG/TGFBR1/P2RX4/MIA3/PPARG/AMOTL1/PIK3CB/PKN2/PTPRM/ARID5B/DOCK1/SEMA4B/AGO2/PTK2/GATA3/PLK2/LGALS8/PLEC/GPC3/EMC10/ANXA3/NFE2L2 56 GO:0061138 morphogenesis of a branching epithelium 30/998 182/18722 3.24511151886829e-08 1.41189393666761e-05 MET/SPINT1/DAG1/MAGED1/NRP1/LAMA5/BMP7/DLG5/LGR4/SPINT2/PBX1/DLG1/LRP5/TGM2/YAP1/TACSTD2/GLI3/KDM5B/TP63/KRAS/FGFR2/CTNNB1/FZD5/MMP14/DDR1/PLXNA1/BCL2/ST14/BTBD7/GPC3 30 GO:0031589 cell-substrate adhesion 46/998 363/18722 4.46925613365143e-08 1.79492202106109e-05 ITGA6/LAMB1/ITGB4/DAG1/LAMC1/KANK1/FBLN1/NRP1/ITGAV/RASA1/LAMA5/UTRN/CCDC80/ITGB5/ITGB1/BCAM/P4HB/CDK6/NF1/LRP1/SLK/GCNT2/CALR/TACSTD2/FERMT1/EFNA1/PPFIA1/SLC9A1/FERMT2/MACF1/ACTN4/SORBS1/TRIOBP/PIK3CB/JAM3/TRPM7/CTNNB1/DOCK1/MMP14/DDR1/NEDD9/PTK2/BCL2/PTPRA/GSK3B/PHLDB2 46 GO:0042176 regulation of protein catabolic process 48/998 391/18722 6.16924627452478e-08 2.30068819994956e-05 EGFR/LRP2/CDH1/GJA1/DDB1/LRP1/RNF128/GNA12/PTTG1IP/MDM2/PSMD1/USP25/RNF217/HECTD1/EFNA1/HUWE1/RAD23B/UFL1/MYCBP2/EZR/FMR1/NEDD4/TMTC3/HSP90AA1/BCAP31/VCP/VGLL4/WWP1/NRDC/SH3D19/RDX/MYLIP/PTK2/AZIN1/SMARCC1/PLK2/HSPA1B/GSK3B/OPHN1/GPC3/TMF1/ALAD/VPS35/NFE2L2/USP14/TMEM259/ATRAID/ANXA2 48 GO:0022604 regulation of cell morphogenesis 41/998 309/18722 6.76472847258786e-08 2.33598789106647e-05 MYH10/DAG1/KANK1/FBLN1/NRP1/RASA1/P4HB/DLG1/CLDN4/RHOBTB3/CALR/CUX1/BRWD1/PRKDC/HEXB/DVL3/TACSTD2/OBSL1/FMNL2/PLXNB1/CDKL5/SPAG9/FERMT2/MACF1/EPB41L3/EZR/ACTN4/TRIOBP/LARP4/DHX36/DOCK1/SH3D19/ARHGAP18/RDX/PLXNA1/NEDD9/PTK2/EPS8/RND3/PRPF40A/MAP3K13 41 GO:1990778 protein localization to cell periphery 43/998 333/18722 7.15874473416271e-08 2.33598789106647e-05 EGFR/CDH1/DAG1/GOLGA4/LAMA5/ITGB1/DLG1/ANK3/LRP1/ARL6IP5/CLTC/ATP2B4/DENND4C/HECTD1/PPFIA1/CLN3/MACF1/TMEM150A/BSG/EPB41L3/TMEM59/EZR/PRKCI/TPBG/SORBS1/CLSTN1/RAB31/GNAI1/MAP7/PKP2/GOPC/MMP14/RDX/SPTBN1/ACSL3/FLOT2/GPSM2/RABEP1/LYPLA1/VPS35/NSG1/ANXA2/KRT18 43 GO:1903829 positive regulation of cellular protein localization 38/998 276/18722 7.69526068970085e-08 2.36335035652519e-05 EGFR/CDH1/TCAF1/TFRC/ITGB1/DLG1/SLC5A3/ANK3/LRP1/PARP1/YAP1/ATP2B4/GLI3/TPR/HUWE1/LIMK2/CLN3/FERMT2/CD2AP/LEPROT/RTN4/EZR/PRKCI/SORBS1/NPEPPS/MAPK14/TM9SF4/GNAI1/FZD5/MYO1C/RDX/SPTBN1/UBR5/ACSL3/GSK3B/GPSM2/STOM/GPD1L 38 GO:0048732 gland development 51/998 436/18722 1.1384631301319e-07 3.22250713157912e-05 EGFR/CDH1/MET/WLS/DAG1/NRP1/LAMA5/BMP7/SERPINF1/PBX1/LMO4/NF1/LRP5/TGM2/PRLR/TGFBR3/PRKDC/TFCP2L1/ASH1L/ISL1/ARHGAP5/GLI3/KDM5B/SRSF5/COBL/CCND1/TP63/IGSF3/RTN4/LSR/TGFBR1/SEC63/KRAS/CDO1/IRF6/FGFR2/ARID5B/CTNNB1/DDR1/PLXNA1/MAN2A1/SMARCC1/GATA3/BCL2/ALDH1A3/ASS1/FASN/BTBD7/PRKCSH/SLC29A1/KRT18 51 GO:0009100 glycoprotein metabolic process 47/998 387/18722 1.17271855008625e-07 3.22250713157912e-05 GALNT11/CTSL/EXTL2/TUSC3/RPN2/C1GALT1/CHPF/GCNT2/FUT8/TRIP11/GXYLT1/DDOST/GANAB/GFPT1/MANBA/B4GALT1/TET2/HS6ST2/STT3B/DPY19L1/MAN1A2/PAWR/TMEM59/NCSTN/B3GNT3/TMTC3/GLCE/TMEM165/GNPTAB/CTNNB1/B3GNT2/MOGS/AGO2/EDEM3/TCF7L2/GCNT4/MAN2A1/BCL2/EXT2/GOLGA2/ARFGEF1/GALNT18/STT3A/B4GAT1/GPC1/RPN1/PRKCSH 47 GO:0009101 glycoprotein biosynthetic process 41/998 317/18722 1.37602106513051e-07 3.47226071389959e-05 GALNT11/EXTL2/TUSC3/RPN2/C1GALT1/CHPF/GCNT2/FUT8/TRIP11/GXYLT1/DDOST/GFPT1/B4GALT1/TET2/HS6ST2/STT3B/DPY19L1/MAN1A2/PAWR/TMEM59/NCSTN/B3GNT3/TMTC3/GLCE/TMEM165/CTNNB1/B3GNT2/MOGS/AGO2/EDEM3/TCF7L2/GCNT4/MAN2A1/BCL2/EXT2/GOLGA2/ARFGEF1/GALNT18/STT3A/B4GAT1/RPN1 41 GO:0030010 establishment of cell polarity 25/998 143/18722 1.39661894257597e-07 3.47226071389959e-05 KANK1/ITGB1/GJA1/AMOT/MPP7/FRMD4A/FERMT1/DOCK8/FAT1/FRMD4B/PRKCI/CYTH3/PARD3/WEE1/AMOTL1/HSP90AA1/JAM3/PTK2/GATA3/MAP4/ARFGEF1/GSK3B/FLOT2/GPSM2/OPHN1 25 GO:0009791 post-embryonic development 18/998 80/18722 1.59566413245854e-07 3.71147047371097e-05 FBN1/EFEMP1/CCDC47/ZFX/ASH1L/KDM5B/ATRX/MYO7A/TGFBR1/FGFR2/ARID5B/PLEKHA1/FZD5/AGO2/PPP1R13L/GATA3/BCL2/ACO1 18 GO:0072659 protein localization to plasma membrane 38/998 284/18722 1.63500901925594e-07 3.71147047371097e-05 EGFR/CDH1/GOLGA4/LAMA5/ITGB1/DLG1/ANK3/LRP1/ARL6IP5/CLTC/ATP2B4/DENND4C/HECTD1/PPFIA1/CLN3/MACF1/TMEM150A/BSG/EPB41L3/TMEM59/EZR/PRKCI/TPBG/SORBS1/RAB31/MAP7/PKP2/GOPC/MMP14/RDX/SPTBN1/ACSL3/FLOT2/LYPLA1/VPS35/NSG1/ANXA2/KRT18 38 GO:0061564 axon development 53/998 467/18722 1.71779995297825e-07 3.73693064770811e-05 APP/NRP2/SEMA6A/SEMA6D/DAG1/NRP1/GOLGA4/LAMA5/BMP7/ITGB1/ANK3/LRP1/EPHB4/MTR/FOLR1/ISL1/EFNA1/GLI3/PLXNB1/COBL/CDKL5/PARD6B/USP9X/NRCAM/RPS6KA5/SIAH1/MACF1/BSG/NREP/MYCBP2/RTN4/SEMA3F/AFG3L2/PARD3/TOP2B/CAMSAP2/HSP90AA1/JAM3/RYK/ZDHHC17/PTPRM/FGFR2/B3GNT2/SEMA4B/DDR1/PLXNA1/PTK2/GATA3/BCL2/GSK3B/OPHN1/CTNNA1/MAP3K13 53 GO:0007229 integrin-mediated signaling pathway 21/998 107/18722 1.84800331439256e-07 3.85937012177742e-05 ITGA6/ITGB4/NRP1/ITGAV/LAMA5/ITGB8/DST/ITGB5/ITGB1/ADAMTS1/FUT8/CD47/PLPP3/VAV3/FERMT1/FERMT2/DOCK1/NEDD9/PTK2/PTPRA/CTNNA1 21 GO:0016055 Wnt signaling pathway 51/998 444/18722 2.01870362122522e-07 4.05371215631418e-05 EGFR/APP/LGR5/WLS/KANK1/RNF43/DDB1/LGR4/TBL1X/CTNND1/LRP5/TLE4/LRP1/CD24/YAP1/ZNRF3/PLPP3/DVL3/FOLR1/ISL1/USP47/FERMT1/GLI3/ATP6V1C2/CCND1/FERMT2/MACF1/SIAH2/TPBG/LATS2/BRD7/AMOTL1/RYK/VCP/FZD6/MAPK14/RBMS3/FGFR2/VGLL4/CTNNB1/FZD5/USP34/TCF7L2/TNKS2/GATA3/DAAM1/TLE1/UBR5/GSK3B/GPC3/VPS35 51 GO:0198738 cell-cell signaling by wnt 51/998 446/18722 2.32264074454862e-07 4.49129901010679e-05 EGFR/APP/LGR5/WLS/KANK1/RNF43/DDB1/LGR4/TBL1X/CTNND1/LRP5/TLE4/LRP1/CD24/YAP1/ZNRF3/PLPP3/DVL3/FOLR1/ISL1/USP47/FERMT1/GLI3/ATP6V1C2/CCND1/FERMT2/MACF1/SIAH2/TPBG/LATS2/BRD7/AMOTL1/RYK/VCP/FZD6/MAPK14/RBMS3/FGFR2/VGLL4/CTNNB1/FZD5/USP34/TCF7L2/TNKS2/GATA3/DAAM1/TLE1/UBR5/GSK3B/GPC3/VPS35 51 GO:0010810 regulation of cell-substrate adhesion 32/998 221/18722 2.5641330373914e-07 4.7811923529359e-05 ITGA6/DAG1/KANK1/FBLN1/NRP1/RASA1/UTRN/CCDC80/P4HB/CDK6/NF1/LRP1/SLK/GCNT2/CALR/TACSTD2/FERMT1/SLC9A1/FERMT2/MACF1/ACTN4/TRIOBP/PIK3CB/DOCK1/MMP14/DDR1/NEDD9/PTK2/BCL2/PTPRA/GSK3B/PHLDB2 32 GO:1903362 regulation of cellular protein catabolic process 35/998 255/18722 2.69240983021545e-07 4.84726611157064e-05 LRP2/LRP1/RNF128/GNA12/PTTG1IP/MDM2/USP25/RNF217/HECTD1/EFNA1/RAD23B/UFL1/EZR/FMR1/TMTC3/HSP90AA1/BCAP31/VCP/VGLL4/RDX/MYLIP/PTK2/SMARCC1/PLK2/HSPA1B/GSK3B/OPHN1/TMF1/ALAD/VPS35/NFE2L2/USP14/TMEM259/ATRAID/ANXA2 35 GO:0007015 actin filament organization 50/998 441/18722 3.95304595893058e-07 6.87961765052552e-05 MET/HSP90B1/KANK1/NRP1/RASA1/ITGB5/DLG1/RHOBTB3/DIAPH2/IQGAP2/LIMA1/CD47/KANK4/SCIN/TACSTD2/PPP1R9A/CALD1/PPFIA1/COBL/WASF2/MYO7A/SLC9A1/FERMT2/CD2AP/FAT1/TJP1/PAWR/EZR/PRKCI/TGFBR1/SORBS1/SWAP70/TRIOBP/MYO1C/ARHGAP18/RDX/NEDD9/NCKAP1/EPS8/BCL2/SPTAN1/SPTBN1/RND3/PLEC/ARFGEF1/ADD3/MYO6/PHLDB2/MICAL3/CTNNA1 50 GO:0006486 protein glycosylation 32/998 226/18722 4.28936245284089e-07 6.99836292696322e-05 GALNT11/EXTL2/TUSC3/RPN2/C1GALT1/GCNT2/FUT8/TRIP11/GXYLT1/DDOST/GFPT1/B4GALT1/TET2/STT3B/DPY19L1/MAN1A2/TMEM59/B3GNT3/TMTC3/TMEM165/B3GNT2/MOGS/EDEM3/GCNT4/MAN2A1/EXT2/GOLGA2/ARFGEF1/GALNT18/STT3A/B4GAT1/RPN1 32 GO:0043413 macromolecule glycosylation 32/998 226/18722 4.28936245284089e-07 6.99836292696322e-05 GALNT11/EXTL2/TUSC3/RPN2/C1GALT1/GCNT2/FUT8/TRIP11/GXYLT1/DDOST/GFPT1/B4GALT1/TET2/STT3B/DPY19L1/MAN1A2/TMEM59/B3GNT3/TMTC3/TMEM165/B3GNT2/MOGS/EDEM3/GCNT4/MAN2A1/EXT2/GOLGA2/ARFGEF1/GALNT18/STT3A/B4GAT1/RPN1 32 GO:0001503 ossification 47/998 408/18722 5.57732795496732e-07 8.82400886451042e-05 FBN2/EGFR/CRIM1/RRBP1/SLC26A2/ATP2B1/BMP7/LGR4/PBX1/CDK6/NF1/LRP5/CCDC47/ANO6/CLTC/SUCO/YAP1/SMOC1/TFAP2A/IL6ST/SND1/ANKH/GLI3/PLXNB1/ATP6V1B1/FERMT2/TP63/UFL1/MSX2/PPARG/MAPK14/FGFR2/CTNNB1/DHX36/SUN1/MMP14/PTK2/SNRNP200/BCL2/EXT2/COL5A2/LTBP3/NIPBL/FASN/GPC3/HNRNPU/ATRAID 47 GO:0048592 eye morphogenesis 24/998 151/18722 1.48526735477324e-06 0.00022807590762562 FBN2/FBN1/TENM3/EFEMP1/BMP7/NF1/LRP5/TFAP2A/OBSL1/GLI3/MYO7A/FAT1/AHI1/TUG1/PRKCI/PTPRM/CTNNB1/FZD5/MAN2A1/BCL2/ALDH1A3/COL5A2/NIPBL/YY1 24 GO:0003018 vascular process in circulatory system 34/998 263/18722 1.6066194395881e-06 0.000234581508273866 EGFR/LRP2/SLC2A1/ATP2B1/SLC6A4/ADRB1/TFRC/GJA1/GJA5/SLC38A1/SLC5A3/LRP1/SLC16A12/SLC19A1/ATP2B4/SLC13A3/SLC16A1/SLC16A2/SLC44A1/FERMT2/TJP1/SLC1A5/YES1/SLC7A2/SLC1A3/SLC5A6/SLC22A5/SLC38A2/EXT2/ABCB1/PLEC/OCLN/SOD3/SLC29A1 34 GO:0070085 glycosylation 32/998 240/18722 1.64958391059969e-06 0.000234581508273866 GALNT11/EXTL2/TUSC3/RPN2/C1GALT1/GCNT2/FUT8/TRIP11/GXYLT1/DDOST/GFPT1/B4GALT1/TET2/STT3B/DPY19L1/MAN1A2/TMEM59/B3GNT3/TMTC3/TMEM165/B3GNT2/MOGS/EDEM3/GCNT4/MAN2A1/EXT2/GOLGA2/ARFGEF1/GALNT18/STT3A/B4GAT1/RPN1 32 GO:0048863 stem cell differentiation 29/998 206/18722 1.66242401956197e-06 0.000234581508273866 NRP2/SEMA6A/SEMA6D/NRP1/MSI2/LAMA5/BMP7/YAP1/FOXO4/PRKDC/N4BP2L2/TACSTD2/FOLR1/ISL1/PUM1/TP63/UFL1/SEMA3F/SETD2/FGFR2/CTNNB1/DHX36/SEMA4B/LTBP3/NFE2L2/HSPA9/HNRNPU/OCIAD1/KRT18 29 GO:0010498 proteasomal protein catabolic process 52/998 490/18722 1.75560307723401e-06 0.000241210622795757 HSP90B1/HSPA5/DDB1/TBL1X/CCDC47/CALR/GNA12/CANX/SKP2/MDM2/UBXN4/PSMD1/USP25/UBE2H/NHLRC3/RNF217/HECTD1/ERLEC1/DNAJB14/HUWE1/KLHL42/SIAH1/RAD23B/STT3B/CD2AP/UBE4B/UFL1/SIAH2/FMR1/NEDD4/TMTC3/BCAP31/VCP/NEMF/CTNNB1/WWP1/SEL1L/EDEM3/SMARCC1/ANAPC5/PLK2/HSPA1B/GSK3B/OPHN1/TMF1/PMAIP1/ALAD/CUL5/UBE2G2/NFE2L2/USP14/TMEM259 52 GO:0030433 ubiquitin-dependent ERAD pathway 17/998 85/18722 2.04016802692066e-06 0.000264861124174663 HSP90B1/HSPA5/CCDC47/CALR/CANX/UBXN4/ERLEC1/DNAJB14/STT3B/UBE4B/BCAP31/VCP/SEL1L/EDEM3/UBE2G2/NFE2L2/USP14 17 GO:1905475 regulation of protein localization to membrane 26/998 175/18722 2.04859698411162e-06 0.000264861124174663 EGFR/TCAF1/DAG1/ITGB1/DLG1/SLC5A3/ANK3/LRP1/CLTC/ATP2B4/HECTD1/PPFIA1/CLN3/TMEM59/EZR/PRKCI/SORBS1/MYO1C/GOPC/MMP14/SPTBN1/ACSL3/STOM/GPC3/GPC1/LYPLA1 26 GO:0045732 positive regulation of protein catabolic process 31/998 231/18722 2.07992838367385e-06 0.000264861124174663 LRP2/GJA1/DDB1/LRP1/RNF128/PTTG1IP/MDM2/RNF217/HECTD1/HUWE1/EZR/FMR1/NEDD4/TMTC3/HSP90AA1/BCAP31/VCP/VGLL4/WWP1/NRDC/SH3D19/RDX/MYLIP/PTK2/PLK2/HSPA1B/GSK3B/GPC3/VPS35/NFE2L2/TMEM259 31 GO:0001890 placenta development 23/998 144/18722 2.24058031016488e-06 0.000274379535772671 SPINT1/MME/BMP7/ITGB8/GJA1/SPINT2/NR2F2/CTSV/ASH1L/HECTD1/MAP3K4/BPTF/BSG/BIRC6/SETD2/PPARG/MAPK14/FGFR2/FZD5/PTK2/ST14/STC2/PHLDA2 23 GO:0060070 canonical Wnt signaling pathway 37/998 303/18722 2.25978165834607e-06 0.000274379535772671 EGFR/LGR5/WLS/KANK1/LGR4/TBL1X/CTNND1/LRP5/TLE4/YAP1/ZNRF3/PLPP3/DVL3/FOLR1/ISL1/USP47/FERMT1/GLI3/SIAH2/TPBG/LATS2/RYK/VCP/FZD6/MAPK14/RBMS3/FGFR2/CTNNB1/FZD5/USP34/TCF7L2/TNKS2/GATA3/TLE1/UBR5/GSK3B/GPC3 37 GO:0007409 axonogenesis 46/998 418/18722 2.6118391642363e-06 0.000309918460829039 APP/NRP2/SEMA6A/SEMA6D/DAG1/NRP1/GOLGA4/LAMA5/BMP7/ITGB1/ANK3/LRP1/EPHB4/ISL1/EFNA1/GLI3/PLXNB1/COBL/CDKL5/PARD6B/USP9X/NRCAM/RPS6KA5/SIAH1/MACF1/BSG/MYCBP2/RTN4/SEMA3F/AFG3L2/PARD3/TOP2B/HSP90AA1/RYK/ZDHHC17/PTPRM/FGFR2/B3GNT2/SEMA4B/PLXNA1/PTK2/GATA3/BCL2/GSK3B/OPHN1/MAP3K13 46 GO:1904375 regulation of protein localization to cell periphery 21/998 125/18722 2.67738061489271e-06 0.000310635648674552 EGFR/DAG1/ITGB1/DLG1/LRP1/CLTC/ATP2B4/HECTD1/PPFIA1/CLN3/TMEM59/EZR/PRKCI/SORBS1/GNAI1/GOPC/MMP14/SPTBN1/ACSL3/GPSM2/LYPLA1 21 GO:0007043 cell-cell junction assembly 23/998 146/18722 2.85545296373756e-06 0.000324093911384213 DLG5/GJA1/DLG1/CTNND1/CLDN4/GJA5/MPP7/PARD6B/MARVELD3/TJP1/EPB41L3/LSR/PARD3/JAM3/PKN2/CTNNB1/PKP2/FZD5/MYO1C/CLDN7/OCLN/MARVELD2/CTNNA1 23 GO:0042060 wound healing 46/998 422/18722 3.37972421091336e-06 0.000363194281174 F5/EGFR/DSP/DAG1/KANK1/FBLN1/LMAN1/DST/ITGB1/GJA1/CLDN4/NF1/ANO6/YAP1/MYOF/PLPP3/GNA12/IL6ST/VAV3/ERBB3/SYT7/B4GALT1/FERMT1/GLI3/FERMT2/MACF1/HPS5/CD59/TGFBR1/DCBLD2/MIA3/PIK3CB/FZD6/MAPK14/FGFR2/ANXA5/DDR1/PTK2/PLEC/ARFGEF1/OCLN/PHLDB2/AK3/NFE2L2/ANXA2/GNAS 46 GO:0032388 positive regulation of intracellular transport 28/998 202/18722 3.39841047856735e-06 0.000363194281174 CDH1/TCAF1/ANK3/PGAP1/DYNC1H1/MDM2/GLI3/TPR/HUWE1/LEPROT/EZR/NEDD4/ICE1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/FZD5/MYO1C/TCF7L2/RDX/UBR5/TMEM30A/GSK3B/STOM/ANXA2 28 GO:0036503 ERAD pathway 19/998 107/18722 3.40864197998965e-06 0.000363194281174 HSP90B1/HSPA5/CCDC47/CALR/CANX/UBXN4/USP25/ERLEC1/DNAJB14/STT3B/UBE4B/BCAP31/VCP/SEL1L/EDEM3/UBE2G2/NFE2L2/USP14/TMEM259 19 GO:0120193 tight junction organization 16/998 80/18722 4.05497430331765e-06 0.000423420416752429 SVEP1/GJA1/DLG1/CLDN4/MPP7/MARVELD3/TJP1/LSR/TGFBR1/PARD3/FZD5/MYO1C/CLDN7/PLEC/OCLN/MARVELD2 16 GO:0072001 renal system development 36/998 302/18722 5.37187122761371e-06 0.000549932150575906 FBN1/LRP2/MME/ADAMTS6/LGR5/MAGED1/NRP1/LAMA5/BMP7/SERPINF1/ENPEP/DLG5/LGR4/PBX1/DLG1/NF1/ADAMTS1/C1GALT1/CD24/YAP1/FRAS1/TFAP2A/TACSTD2/GLI3/IRX2/AHI1/TGFBR1/FGFR2/ARID5B/CTNNB1/GCNT4/GATA3/BCL2/ASS1/NIPBL/GPC3 36 GO:0051222 positive regulation of protein transport 36/998 303/18722 5.79147880998687e-06 0.000581486747441181 EGFR/CDH1/MYH10/TCAF1/WLS/GJA1/ANK3/LRP1/EXPH5/FRMD4A/KCNN4/MDM2/ISL1/EXOC1/GLI3/TPR/HUWE1/CLN3/CD2AP/LEPROT/EZR/ICE1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/FZD5/MYO1C/TCF7L2/UBR5/TMEM30A/ACSL3/GSK3B/STOM 36 GO:0001822 kidney development 35/998 293/18722 6.90095157948221e-06 0.00066880450563244 FBN1/LRP2/MME/ADAMTS6/MAGED1/NRP1/LAMA5/BMP7/SERPINF1/ENPEP/DLG5/LGR4/PBX1/DLG1/NF1/ADAMTS1/C1GALT1/CD24/YAP1/FRAS1/TFAP2A/TACSTD2/GLI3/IRX2/AHI1/TGFBR1/FGFR2/ARID5B/CTNNB1/GCNT4/GATA3/BCL2/ASS1/NIPBL/GPC3 35 GO:0060445 branching involved in salivary gland morphogenesis 8/998 21/18722 6.92235246327187e-06 0.00066880450563244 DAG1/NRP1/LAMA5/BMP7/TGM2/FGFR2/PLXNA1/BTBD7 8 GO:0007160 cell-matrix adhesion 30/998 233/18722 7.0454410668041e-06 0.00066880450563244 ITGB4/DAG1/NRP1/ITGAV/RASA1/UTRN/ITGB5/ITGB1/BCAM/CDK6/NF1/LRP1/SLK/FERMT1/PPFIA1/SLC9A1/FERMT2/MACF1/SORBS1/PIK3CB/JAM3/TRPM7/CTNNB1/MMP14/DDR1/PTK2/BCL2/PTPRA/GSK3B/PHLDB2 30 GO:0034975 protein folding in endoplasmic reticulum 6/998 11/18722 8.28617685465092e-06 0.000772538024252365 HSP90B1/HSPA5/P4HB/PDIA3/CALR/CANX 6 GO:0006457 protein folding 28/998 212/18722 8.69546018029963e-06 0.000796473642128848 HSP90B1/LMAN1/HSPA5/P4HB/PDIA3/CCDC47/CALR/PDIA6/NKTR/SIL1/CANX/HSPD1/PDIA4/DNAJB14/PRDX4/ERP29/DNAJB4/HSP90AA1/MOGS/DNAJC21/RP2/RANBP2/PDIA5/HSPA1B/P3H1/ATF6/PPIB/HSPA9 28 GO:1903076 regulation of protein localization to plasma membrane 18/998 104/18722 8.89128387384843e-06 0.000800368846644183 EGFR/ITGB1/DLG1/LRP1/CLTC/ATP2B4/HECTD1/PPFIA1/CLN3/TMEM59/EZR/PRKCI/SORBS1/GOPC/MMP14/SPTBN1/ACSL3/LYPLA1 18 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 44/998 412/18722 9.27020562451628e-06 0.000820334636705076 HSP90B1/HSPA5/DDB1/TBL1X/CCDC47/CALR/GNA12/CANX/SKP2/MDM2/UBXN4/PSMD1/UBE2H/NHLRC3/RNF217/HECTD1/ERLEC1/DNAJB14/HUWE1/KLHL42/SIAH1/RAD23B/STT3B/CD2AP/UBE4B/UFL1/SIAH2/NEDD4/BCAP31/VCP/NEMF/CTNNB1/WWP1/SEL1L/EDEM3/SMARCC1/ANAPC5/PLK2/HSPA1B/GSK3B/CUL5/UBE2G2/NFE2L2/USP14 44 GO:0007044 cell-substrate junction assembly 17/998 95/18722 9.91240380100128e-06 0.000843860261654691 ITGA6/ITGB4/LAMC1/NRP1/DST/LRP1/SLK/SLC9A1/FERMT2/MACF1/SORBS1/MMP14/PTK2/BCL2/PLEC/PTPRA/PHLDB2 17 GO:0051017 actin filament bundle assembly 23/998 157/18722 9.93732553023845e-06 0.000843860261654691 MET/HSP90B1/NRP1/ITGB5/LIMA1/CD47/TACSTD2/PPP1R9A/CALD1/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/PAWR/EZR/TGFBR1/SORBS1/SWAP70/RDX/NEDD9/EPS8/PHLDB2 23 GO:0010720 positive regulation of cell development 35/998 298/18722 1.00209416247062e-05 0.000843860261654691 EGFR/LRP2/SPINT1/MME/DAG1/NRP1/GOLGA4/SERPINF1/P4HB/TGM2/LRP1/CALR/CUX1/PRKDC/IL6ST/OBSL1/GLI3/PLXNB1/CDKL5/FERMT2/MACF1/UFL1/S1PR2/PRKCI/DICER1/TRIOBP/CTNNB1/DHX36/DOCK1/PLXNA1/NEDD9/MAN2A1/BCL2/MAP3K13/HDAC2 35 GO:0010769 regulation of cell morphogenesis involved in differentiation 17/998 96/18722 1.14557562503177e-05 0.000937510785418564 KANK1/FBLN1/NRP1/P4HB/CALR/CUX1/PRKDC/TACSTD2/OBSL1/CDKL5/FERMT2/ACTN4/TRIOBP/DHX36/DOCK1/NEDD9/PTK2 17 GO:0060562 epithelial tube morphogenesis 37/998 325/18722 1.1492183540852e-05 0.000937510785418564 LRP2/MET/SPINT1/LGR5/DAG1/MAGED1/NRP1/LAMA5/BMP7/DLG5/LGR4/SPINT2/PBX1/LMO4/DLG1/LRP5/YAP1/DVL3/TACSTD2/FOLR1/HECTD1/GLI3/KDM5B/COBL/IRX2/AHI1/SETD2/KRAS/FZD6/FGFR2/CTNNB1/MMP14/DDR1/GATA3/BCL2/ST14/GPC3 37 GO:0001655 urogenital system development 38/998 338/18722 1.17325092241271e-05 0.000942391240910269 FBN1/LRP2/MME/ADAMTS6/LGR5/MAGED1/NRP1/LAMA5/BMP7/SERPINF1/ENPEP/DLG5/LGR4/PBX1/DLG1/NF1/ADAMTS1/C1GALT1/CD24/YAP1/FRAS1/TFAP2A/TACSTD2/GLI3/IRX2/TP63/AHI1/TGFBR1/FGFR2/ARID5B/CTNNB1/GCNT4/SMARCC1/GATA3/BCL2/ASS1/NIPBL/GPC3 38 GO:0043484 regulation of RNA splicing 22/998 148/18722 1.21625453990594e-05 0.000962131053461953 MBNL3/AHNAK/FUS/RBM39/SON/SF1/SRSF5/DDX17/MBNL2/RBM25/ESRP1/RBM5/FMR1/TRA2B/SLC38A2/RBFOX2/POLR2A/QKI/SRSF4/TIA1/HNRNPU/SRSF2 22 GO:0043297 apical junction assembly 15/998 78/18722 1.33088968148078e-05 0.00103710075030017 DLG5/GJA1/DLG1/CLDN4/MPP7/MARVELD3/TJP1/PARD3/PKN2/FZD5/MYO1C/CLDN7/OCLN/MARVELD2/CTNNA1 15 GO:0001649 osteoblast differentiation 29/998 229/18722 1.37376995896417e-05 0.00103948593561622 FBN2/CRIM1/RRBP1/BMP7/LGR4/CDK6/NF1/LRP5/CCDC47/CLTC/SUCO/YAP1/SMOC1/IL6ST/SND1/GLI3/FERMT2/TP63/UFL1/MSX2/PPARG/MAPK14/FGFR2/CTNNB1/PTK2/SNRNP200/FASN/HNRNPU/ATRAID 29 GO:0033157 regulation of intracellular protein transport 29/998 229/18722 1.37376995896417e-05 0.00103948593561622 CDH1/TCAF1/LMAN1/ANK3/PTPN14/MDM2/FERMT1/ERLEC1/GLI3/TPR/HUWE1/LEPROT/ICE1/PTPN1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/GCC2/FZD5/MYO1C/TCF7L2/UBR5/TMEM30A/GSK3B/STOM/UBE2G2 29 GO:0030111 regulation of Wnt signaling pathway 37/998 328/18722 1.41272190019709e-05 0.00103991385345487 EGFR/APP/LGR5/WLS/KANK1/RNF43/LGR4/TBL1X/CTNND1/TLE4/LRP1/YAP1/ZNRF3/PLPP3/FOLR1/ISL1/USP47/FERMT1/GLI3/ATP6V1C2/MACF1/SIAH2/TPBG/LATS2/VCP/FZD6/MAPK14/RBMS3/FGFR2/VGLL4/USP34/TCF7L2/TNKS2/TLE1/UBR5/GSK3B/GPC3 37 GO:0001952 regulation of cell-matrix adhesion 20/998 128/18722 1.41417130042704e-05 0.00103991385345487 DAG1/NRP1/RASA1/UTRN/CDK6/NF1/LRP1/SLK/FERMT1/SLC9A1/FERMT2/MACF1/PIK3CB/MMP14/DDR1/PTK2/BCL2/PTPRA/GSK3B/PHLDB2 20 GO:0061572 actin filament bundle organization 23/998 161/18722 1.51236537214424e-05 0.00109667494555071 MET/HSP90B1/NRP1/ITGB5/LIMA1/CD47/TACSTD2/PPP1R9A/CALD1/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/PAWR/EZR/TGFBR1/SORBS1/SWAP70/RDX/NEDD9/EPS8/PHLDB2 23 GO:0048880 sensory system development 41/998 381/18722 1.54886186858226e-05 0.00110775449532438 FBN2/FBN1/TENM3/EFEMP1/ATP2B1/NRP1/BMP7/SERPINF1/PBX1/DLG1/NF1/LRP5/ATP2B4/SMOC1/TFAP2A/ISL1/OBSL1/GLI3/KDM5B/LIMK2/MYO7A/FAT1/AHI1/TUG1/PRKCI/TGFBR1/CRYBG3/PTPRM/CTNNB1/FZD5/MAN2A1/PPP1R13L/GATA3/BCL2/ALDH1A3/COL5A2/NIPBL/MEIS2/ATF6/HDAC2/YY1 41 GO:0032535 regulation of cellular component size 41/998 382/18722 1.64827176116753e-05 0.00116292254933185 SEMA6A/SEMA6D/KANK1/NRP1/GOLGA4/RASA1/DLG1/ANO6/LRP1/IQGAP2/LIMA1/KANK4/SCIN/KCNN4/VAV3/PPP1R9A/CDKL5/SLC12A9/WASF2/NRCAM/CLN3/MACF1/RTN4/EZR/SEMA3F/SWAP70/TRIOBP/RYK/HP1BP3/MYO1C/SEMA4B/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/GSK3B/MAP3K13 41 GO:0048754 branching morphogenesis of an epithelial tube 22/998 151/18722 1.68140821218094e-05 0.00117048430343956 MET/DAG1/MAGED1/NRP1/LAMA5/BMP7/DLG5/LGR4/PBX1/DLG1/LRP5/YAP1/TACSTD2/GLI3/KDM5B/KRAS/FGFR2/CTNNB1/MMP14/DDR1/BCL2/GPC3 22 GO:0090596 sensory organ morphogenesis 31/998 256/18722 1.73595643240158e-05 0.00117874459415104 FBN2/FBN1/TENM3/EFEMP1/BMP7/NF1/LRP5/TFAP2A/OBSL1/GLI3/ATP6V1B1/MYO7A/FAT1/AHI1/TUG1/PRKCI/TRIOBP/FZD6/PTPRM/FGFR2/CTNNB1/FZD5/MAN2A1/GATA3/BCL2/ALDH1A3/COL5A2/NIPBL/MYO6/HDAC2/YY1 31 GO:0032970 regulation of actin filament-based process 42/998 396/18722 1.73842815073032e-05 0.00117874459415104 DSP/MET/DSC2/KANK1/NRP1/RASA1/AKAP9/DLG1/GJA5/DSG2/RHOBTB3/LRP1/IQGAP2/LIMA1/CD47/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/CD2AP/TJP1/TGFBR1/SWAP70/TRIOBP/JAM3/PKP2/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/RND3/ATP2A2/ARFGEF1/ADD3/PHLDB2 42 GO:0035272 exocrine system development 11/998 45/18722 1.78077222293012e-05 0.00118164966659049 WLS/DAG1/NRP1/LAMA5/BMP7/TGM2/TFCP2L1/IGSF3/FGFR2/PLXNA1/BTBD7 11 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 20/998 130/18722 1.78797785214804e-05 0.00118164966659049 LMAN1/PGAP1/TMED4/TRIP11/ERGIC3/SEC31A/CREB3L2/TMED9/ERGIC2/COPB1/MIA3/BCAP31/VCP/USO1/GOPC/GOLGA2/COPB2/TMED1/TFG/KDELR1 20 GO:1904951 positive regulation of establishment of protein localization 36/998 319/18722 1.82070091641872e-05 0.00118823493557777 EGFR/CDH1/MYH10/TCAF1/WLS/GJA1/ANK3/LRP1/EXPH5/FRMD4A/KCNN4/MDM2/ISL1/EXOC1/GLI3/TPR/HUWE1/CLN3/CD2AP/LEPROT/EZR/ICE1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/FZD5/MYO1C/TCF7L2/UBR5/TMEM30A/ACSL3/GSK3B/STOM 36 GO:0001654 eye development 40/998 371/18722 1.87520011476769e-05 0.00120869380237063 FBN2/FBN1/TENM3/EFEMP1/ATP2B1/NRP1/BMP7/SERPINF1/PBX1/DLG1/NF1/LRP5/ATP2B4/SMOC1/TFAP2A/OBSL1/GLI3/KDM5B/LIMK2/MYO7A/FAT1/AHI1/TUG1/PRKCI/TGFBR1/CRYBG3/PTPRM/CTNNB1/FZD5/MAN2A1/PPP1R13L/GATA3/BCL2/ALDH1A3/COL5A2/NIPBL/MEIS2/ATF6/HDAC2/YY1 40 GO:0098656 anion transmembrane transport 30/998 245/18722 1.9024628226047e-05 0.00121131199961209 LRP2/TCAF1/SLC26A2/SLC13A4/ITGB1/GJA1/SLC38A9/GABRE/SLC43A2/ANO6/ARL6IP5/SLC35B4/SLC16A12/SLC19A1/PCYOX1/SLC13A3/FOLR1/ANKH/SLC16A1/SLC12A9/SLC9A1/SLC1A5/SLC7A2/SLC35D1/SLC1A3/SLC5A6/GABRA4/SLC20A2/GOPC/ABCB1 30 GO:0150115 cell-substrate junction organization 17/998 101/18722 2.28719019847203e-05 0.00143872530436415 ITGA6/ITGB4/LAMC1/NRP1/DST/LRP1/SLK/SLC9A1/FERMT2/MACF1/SORBS1/MMP14/PTK2/BCL2/PLEC/PTPRA/PHLDB2 17 GO:0150063 visual system development 40/998 375/18722 2.40269755741499e-05 0.00149339094610282 FBN2/FBN1/TENM3/EFEMP1/ATP2B1/NRP1/BMP7/SERPINF1/PBX1/DLG1/NF1/LRP5/ATP2B4/SMOC1/TFAP2A/OBSL1/GLI3/KDM5B/LIMK2/MYO7A/FAT1/AHI1/TUG1/PRKCI/TGFBR1/CRYBG3/PTPRM/CTNNB1/FZD5/MAN2A1/PPP1R13L/GATA3/BCL2/ALDH1A3/COL5A2/NIPBL/MEIS2/ATF6/HDAC2/YY1 40 GO:1903364 positive regulation of cellular protein catabolic process 22/998 155/18722 2.54952098539635e-05 0.00156091985937564 LRP2/LRP1/RNF128/PTTG1IP/MDM2/RNF217/HECTD1/EZR/FMR1/TMTC3/HSP90AA1/BCAP31/VCP/VGLL4/RDX/PTK2/PLK2/HSPA1B/GSK3B/VPS35/NFE2L2/TMEM259 22 GO:0032386 regulation of intracellular transport 37/998 337/18722 2.57113786451456e-05 0.00156091985937564 CDH1/TCAF1/LMAN1/ANK3/PGAP1/PTPN14/DYNC1H1/MDM2/FERMT1/ERLEC1/GLI3/TPR/HUWE1/LEPROT/EZR/NEDD4/ICE1/SETD2/PTPN1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/GCC2/FZD5/MYO1C/TCF7L2/RDX/UBR5/TMEM30A/GSK3B/STOM/REEP5/UBE2G2/ANXA2 37 GO:0050767 regulation of neurogenesis 39/998 364/18722 2.7368802697049e-05 0.00164244274576198 EGFR/LRP2/SPINT1/MME/SEMA6A/SEMA6D/DAG1/NRP1/GOLGA4/BMP7/SERPINF1/NF1/TGM2/LRP1/YAP1/CUX1/IL6ST/PRTG/OBSL1/GLI3/PLXNB1/CDKL5/MACF1/UFL1/RTN4/SEMA3F/PRKCI/DICER1/RYK/PCM1/CTNNB1/DHX36/SEMA4B/BHLHE41/PLXNA1/MAN2A1/CTNNA1/MAP3K13/HDAC2 39 GO:0043588 skin development 31/998 263/18722 2.95273106049711e-05 0.00175184191668812 EGFR/ITGA6/DSP/MET/ITGB4/LGR5/LAMA5/NCOA3/LGR4/CLDN4/EXPH5/YAP1/FRAS1/OPN3/ASH1L/FERMT1/TP63/DHCR24/LSR/IRF6/ERRFI1/FZD6/FGFR2/GRHL1/CTNNB1/BCL2/ST14/SGPP1/PLEC/COL5A2/HDAC2 31 GO:0060993 kidney morphogenesis 16/998 93/18722 2.98825214970926e-05 0.00175237625654607 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/FRAS1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GCNT4/GATA3/BCL2/GPC3 16 GO:0030198 extracellular matrix organization 34/998 301/18722 3.02425961850274e-05 0.00175237625654607 APP/SPINT1/ADAMTS6/LAMB1/ADAMTSL4/COL14A1/DAG1/LAMC1/FBLN1/DPP4/CCDC80/ITGB1/SPINT2/NF1/VWA1/ADAMTS1/LRP1/SERPINH1/CTSV/SMOC1/B4GALT1/FERMT1/COL4A2/PRDX4/ADAMTS19/MMP15/TGFBR1/MMP14/DDR1/ST7/COL5A2/LTBP3/PHLDB2/ANXA2 34 GO:0051642 centrosome localization 9/998 32/18722 3.08961395318942e-05 0.00175237625654607 SYNE2/AKAP9/DLG1/EZR/PARD3/DYNC1LI2/SUN1/RANBP2/GPSM2 9 GO:0072337 modified amino acid transport 9/998 32/18722 3.08961395318942e-05 0.00175237625654607 LRP2/GJA1/SLC16A12/SLC19A1/SLC13A3/FOLR1/SLC5A6/SLC22A5/SLC38A2 9 GO:0007411 axon guidance 28/998 227/18722 3.12145167321939e-05 0.00175237625654607 APP/NRP2/SEMA6A/SEMA6D/DAG1/NRP1/LAMA5/BMP7/LRP1/EPHB4/ISL1/EFNA1/GLI3/PLXNB1/NRCAM/RPS6KA5/SIAH1/BSG/MYCBP2/SEMA3F/RYK/PTPRM/B3GNT2/SEMA4B/PLXNA1/PTK2/GATA3/OPHN1 28 GO:0043062 extracellular structure organization 34/998 302/18722 3.23795959210318e-05 0.00179844542876284 APP/SPINT1/ADAMTS6/LAMB1/ADAMTSL4/COL14A1/DAG1/LAMC1/FBLN1/DPP4/CCDC80/ITGB1/SPINT2/NF1/VWA1/ADAMTS1/LRP1/SERPINH1/CTSV/SMOC1/B4GALT1/FERMT1/COL4A2/PRDX4/ADAMTS19/MMP15/TGFBR1/MMP14/DDR1/ST7/COL5A2/LTBP3/PHLDB2/ANXA2 34 GO:0097485 neuron projection guidance 28/998 228/18722 3.38168721153163e-05 0.0018585040980428 APP/NRP2/SEMA6A/SEMA6D/DAG1/NRP1/LAMA5/BMP7/LRP1/EPHB4/ISL1/EFNA1/GLI3/PLXNB1/NRCAM/RPS6KA5/SIAH1/BSG/MYCBP2/SEMA3F/RYK/PTPRM/B3GNT2/SEMA4B/PLXNA1/PTK2/GATA3/OPHN1 28 GO:0061326 renal tubule development 16/998 94/18722 3.42568572236613e-05 0.00186307345379933 LGR5/MAGED1/LAMA5/LGR4/PBX1/DLG1/CD24/YAP1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 16 GO:0043001 Golgi to plasma membrane protein transport 10/998 40/18722 3.47001084255143e-05 0.0018677243926764 GOLGA4/ANK3/CLN3/MACF1/RAB31/GOPC/SPTBN1/ACSL3/LYPLA1/KRT18 10 GO:0060828 regulation of canonical Wnt signaling pathway 30/998 253/18722 3.52452596016674e-05 0.00187770918755414 EGFR/LGR5/WLS/KANK1/LGR4/TBL1X/CTNND1/TLE4/YAP1/ZNRF3/FOLR1/ISL1/USP47/FERMT1/GLI3/SIAH2/TPBG/LATS2/VCP/FZD6/MAPK14/RBMS3/FGFR2/USP34/TCF7L2/TNKS2/TLE1/UBR5/GSK3B/GPC3 30 GO:0061333 renal tubule morphogenesis 14/998 75/18722 3.63935497308315e-05 0.00191930023378456 LGR5/MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 14 GO:0045229 external encapsulating structure organization 34/998 304/18722 3.70711445853787e-05 0.00193548445880262 APP/SPINT1/ADAMTS6/LAMB1/ADAMTSL4/COL14A1/DAG1/LAMC1/FBLN1/DPP4/CCDC80/ITGB1/SPINT2/NF1/VWA1/ADAMTS1/LRP1/SERPINH1/CTSV/SMOC1/B4GALT1/FERMT1/COL4A2/PRDX4/ADAMTS19/MMP15/TGFBR1/MMP14/DDR1/ST7/COL5A2/LTBP3/PHLDB2/ANXA2 34 GO:1900024 regulation of substrate adhesion-dependent cell spreading 12/998 57/18722 3.76119583981063e-05 0.0019442775722427 KANK1/FBLN1/NRP1/P4HB/CALR/TACSTD2/FERMT2/ACTN4/TRIOBP/DOCK1/NEDD9/PTK2 12 GO:0061842 microtubule organizing center localization 9/998 33/18722 4.04847773548114e-05 0.00207226492715167 SYNE2/AKAP9/DLG1/EZR/PARD3/DYNC1LI2/SUN1/RANBP2/GPSM2 9 GO:0090316 positive regulation of intracellular protein transport 22/998 160/18722 4.1898269574424e-05 0.00209917097551709 CDH1/TCAF1/ANK3/MDM2/GLI3/TPR/HUWE1/LEPROT/ICE1/NPEPPS/BCAP31/MAPK14/TM9SF4/PCM1/TMEM30B/FZD5/MYO1C/TCF7L2/UBR5/TMEM30A/GSK3B/STOM 22 GO:0072028 nephron morphogenesis 14/998 76/18722 4.24518643133656e-05 0.00209917097551709 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 14 GO:0030048 actin filament-based movement 19/998 127/18722 4.27806465736229e-05 0.00209917097551709 DSP/SYNE2/MYH10/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/FNBP1L/WASF2/MYO7A/SLC9A1/ACTN4/PKP2/MYO1C/ATP2A2/MYO6/GPD1L 19 GO:1905039 carboxylic acid transmembrane transport 21/998 149/18722 4.29578766105587e-05 0.00209917097551709 LRP2/SLC2A1/ITGB1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC19A1/SLC13A3/FOLR1/SLC7A6/SLC16A1/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC5A6/CPT2/SLC38A2/ABCB1/SLC38A10 21 GO:0071559 response to transforming growth factor beta 30/998 256/18722 4.40249890243509e-05 0.00209917097551709 FBN2/FBN1/PEG10/ITGB8/HSPA5/ITGB5/GLG1/PARP1/GCNT2/TGFBR3/FUT8/ZNF451/TRIM33/FOLR1/FERMT1/ZFHX3/USP9X/COL4A2/FERMT2/NREP/YES1/LATS2/TGFBR1/PPARG/FGFR2/CDKN1C/PTK2/LTBP3/EID2/HDAC2 30 GO:0048736 appendage development 23/998 172/18722 4.42269311064699e-05 0.00209917097551709 FBN2/ITGA6/ITGB4/BMP7/PBX1/NR2F2/LRP5/ZNRF3/FRAS1/SMOC1/TFAP2A/GLI3/ATRX/FERMT2/TP63/IRF6/FZD6/SLC39A1/FGFR2/CTNNB1/NIPBL/GPC3/HDAC2 23 GO:0060173 limb development 23/998 172/18722 4.42269311064699e-05 0.00209917097551709 FBN2/ITGA6/ITGB4/BMP7/PBX1/NR2F2/LRP5/ZNRF3/FRAS1/SMOC1/TFAP2A/GLI3/ATRX/FERMT2/TP63/IRF6/FZD6/SLC39A1/FGFR2/CTNNB1/NIPBL/GPC3/HDAC2 23 GO:1990138 neuron projection extension 23/998 172/18722 4.42269311064699e-05 0.00209917097551709 NRP2/SEMA6A/SEMA6D/NRP1/GOLGA4/ITGB1/LRP1/CDKL5/USP9X/NRCAM/SPAG9/MACF1/RTN4/SEMA3F/HSP90AA1/RYK/EIF2AK4/CTNNB1/SEMA4B/DDR1/PLXNA1/GSK3B/MAP3K13 23 GO:1903825 organic acid transmembrane transport 21/998 150/18722 4.7491142354845e-05 0.002233795083195 LRP2/SLC2A1/ITGB1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC19A1/SLC13A3/FOLR1/SLC7A6/SLC16A1/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC5A6/CPT2/SLC38A2/ABCB1/SLC38A10 21 GO:0010639 negative regulation of organelle organization 37/998 347/18722 4.83240904163942e-05 0.00225267925057138 MET/KANK1/BMP7/TFRC/PARP1/YAP1/LIMA1/KANK4/SCIN/TACSTD2/PPP1R9A/RAD50/ATRX/TPR/PPFIA1/HUWE1/WASF2/LIMK2/TJP1/DCP2/SWAP70/CAMSAP2/PPARG/TRIOBP/RAD21/RDX/TNKS2/WAPL/EPS8/SPTAN1/SPTBN1/MAP4/ARFGEF1/ADD3/PHLDB2/LMNA/HNRNPU 37 GO:0021675 nerve development 14/998 77/18722 4.93746209400987e-05 0.00228128226485182 NRP2/DAG1/NRP1/CTSV/TFAP2A/ERBB3/ISL1/GLI3/SEMA3F/AFG3L2/DICER1/SLC1A3/NAV2/CTNNB1 14 GO:0016032 viral process 42/998 415/18722 5.22245873105734e-05 0.00238222814429735 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/DDB1/HACD3/P4HB/CD55/ANO6/FUT8/EEA1/CANX/SLC52A1/EIF3A/BSG/SLC1A5/MPHOSPH8/FMR1/NEDD4/TOP2B/UVRAG/PKN2/EIF2AK4/VCP/SLC20A2/WWP1/MOGS/DENR/MAN2A1/BCL2/HSPA1B/GSK3B/STOM/HEXIM1/SLC52A2/PPIB 42 GO:0007431 salivary gland development 9/998 34/18722 5.24719855572103e-05 0.00238222814429735 DAG1/NRP1/LAMA5/BMP7/TGM2/TFCP2L1/FGFR2/PLXNA1/BTBD7 9 GO:0060560 developmental growth involved in morphogenesis 28/998 234/18722 5.39943288847286e-05 0.00243021026816524 APP/NRP2/SEMA6A/SEMA6D/NRP1/GOLGA4/ITGB1/LRP1/YAP1/KDM5B/COBL/CDKL5/USP9X/NRCAM/SPAG9/MACF1/RTN4/SEMA3F/HSP90AA1/RYK/EIF2AK4/FGFR2/CTNNB1/SEMA4B/DDR1/PLXNA1/GSK3B/MAP3K13 28 GO:0051960 regulation of nervous system development 44/998 443/18722 5.45506958525385e-05 0.00243426652176157 EGFR/LRP2/SPINT1/MME/SEMA6A/SEMA6D/DAG1/NRP1/GOLGA4/BMP7/SERPINF1/DLG5/DLG1/NF1/TGM2/LRP1/YAP1/CUX1/IL6ST/PRTG/OBSL1/GLI3/PLXNB1/CDKL5/MACF1/UFL1/RTN4/SEMA3F/PRKCI/TPBG/DICER1/PARD3/CLSTN1/RYK/PCM1/CTNNB1/DHX36/SEMA4B/BHLHE41/PLXNA1/MAN2A1/CTNNA1/MAP3K13/HDAC2 44 GO:0007179 transforming growth factor beta receptor signaling pathway 25/998 198/18722 5.53889365014245e-05 0.00243434357920801 FBN2/FBN1/PEG10/ITGB8/HSPA5/ITGB5/GLG1/PARP1/GCNT2/TGFBR3/FUT8/ZNF451/TRIM33/FOLR1/FERMT1/USP9X/FERMT2/NREP/LATS2/TGFBR1/PPARG/CDKN1C/PTK2/LTBP3/EID2 25 GO:0034446 substrate adhesion-dependent cell spreading 17/998 108/18722 5.54849427170567e-05 0.00243434357920801 LAMB1/LAMC1/KANK1/FBLN1/NRP1/ITGAV/LAMA5/P4HB/CALR/TACSTD2/EFNA1/FERMT2/ACTN4/TRIOBP/DOCK1/NEDD9/PTK2 17 GO:0098901 regulation of cardiac muscle cell action potential 8/998 27/18722 5.67257901877928e-05 0.00246804458808722 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/PKP2/ATP2A2 8 GO:1904377 positive regulation of protein localization to cell periphery 13/998 69/18722 6.20079192292535e-05 0.00267556484542093 EGFR/ITGB1/DLG1/LRP1/ATP2B4/CLN3/EZR/PRKCI/SORBS1/GNAI1/SPTBN1/ACSL3/GPSM2 13 GO:0048762 mesenchymal cell differentiation 28/998 236/18722 6.28158176611031e-05 0.00268820806564442 NRP2/SEMA6A/SEMA6D/DAG1/NRP1/LAMA5/BMP7/DLG5/GCNT2/TGFBR3/FOLR1/ISL1/EFNA1/DDX17/FERMT2/RTN4/SEMA3F/TGFBR1/FGFR2/CTNNB1/SEMA4B/TCF7L2/GATA3/BCL2/PDCD4/GSK3B/PHLDB2/HDAC2 28 GO:0006893 Golgi to plasma membrane transport 12/998 60/18722 6.42128874781506e-05 0.0027036732703502 GOLGA4/ANK3/EXOC1/CLN3/MACF1/RAB31/GOPC/SPTBN1/ACSL3/RABEP1/LYPLA1/KRT18 12 GO:0061951 establishment of protein localization to plasma membrane 12/998 60/18722 6.42128874781506e-05 0.0027036732703502 GOLGA4/ANK3/CLN3/MACF1/RAB31/GOPC/SPTBN1/ACSL3/LYPLA1/VPS35/NSG1/KRT18 12 GO:0048675 axon extension 18/998 120/18722 6.51278590375528e-05 0.00272026041628051 NRP2/SEMA6A/SEMA6D/NRP1/GOLGA4/ITGB1/LRP1/CDKL5/USP9X/NRCAM/MACF1/RTN4/SEMA3F/HSP90AA1/RYK/SEMA4B/GSK3B/MAP3K13 18 GO:0071560 cellular response to transforming growth factor beta stimulus 29/998 250/18722 7.05013470784461e-05 0.00292132962775053 FBN2/FBN1/PEG10/ITGB8/HSPA5/ITGB5/GLG1/PARP1/GCNT2/TGFBR3/FUT8/ZNF451/TRIM33/FOLR1/FERMT1/USP9X/COL4A2/FERMT2/NREP/YES1/LATS2/TGFBR1/PPARG/FGFR2/CDKN1C/PTK2/LTBP3/EID2/HDAC2 29 GO:0045056 transcytosis 7/998 21/18722 7.19908175691616e-05 0.00293643795725463 LRP2/LRPAP1/IGF1R/LRP1/CLTC/USO1/VPS35 7 GO:0048485 sympathetic nervous system development 7/998 21/18722 7.19908175691616e-05 0.00293643795725463 NRP2/NRP1/NF1/TP63/SEMA3F/CTNNB1/GATA3 7 GO:0015711 organic anion transport 37/998 354/18722 7.36443619351735e-05 0.00298059855553132 LRP2/SLC26A2/SLC2A1/ITGB1/GJA1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC35B4/SLC16A12/CD47/SLC22A11/SLC19A1/SLC13A3/SLC52A1/SLC16A4/FOLR1/CYB5R1/SLC7A6/SLC16A1/SLC16A2/PLEKHA8/CLN3/SLC1A5/SLC7A2/SLC35D1/SLC1A3/PLA2R1/SLC5A6/P2RX4/SLC38A2/SLC17A5/SLC52A3/SERINC3/SLC52A2/SLC29A1 37 GO:0051056 regulation of small GTPase mediated signal transduction 33/998 302/18722 7.5778279020177e-05 0.00304337226741803 MET/ADGRG1/KANK1/NRP1/ITGAV/RASA1/ITGB1/AMOT/TGM2/ARHGAP21/FAM13A/NET1/VAV3/ABCA1/ARHGAP5/DENND4C/CCDC125/SYDE2/DOCK8/CD2AP/ARHGAP23/ARHGAP32/CYTH3/SWAP70/PIK3CB/KRAS/ARFGEF3/ARHGAP18/CHN2/RDX/EPS8/ARFGEF1/OPHN1 33 GO:0002028 regulation of sodium ion transport 15/998 90/18722 7.67525512177157e-05 0.00305896999929537 UTRN/DLG1/FXYD3/ANK3/ATP2B4/DMD/PRSS8/SLC9A1/NEDD4/ACTN4/P2RX4/AHCYL1/PKP2/STOM/GPD1L 15 GO:0046718 viral entry into host cell 20/998 144/18722 7.98843844144226e-05 0.00315966947748258 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/P4HB/CD55/SLC52A1/BSG/SLC1A5/UVRAG/SLC20A2/WWP1/HSPA1B/SLC52A2 20 GO:0048024 regulation of mRNA splicing, via spliceosome 16/998 101/18722 8.41647797667114e-05 0.00329066799181715 MBNL3/RBM39/SON/SF1/DDX17/MBNL2/RBM25/RBM5/FMR1/TRA2B/RBFOX2/QKI/SRSF4/TIA1/HNRNPU/SRSF2 16 GO:0072078 nephron tubule morphogenesis 13/998 71/18722 8.44569068959007e-05 0.00329066799181715 MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 13 GO:0048638 regulation of developmental growth 35/998 330/18722 8.5261358990733e-05 0.00329192004089955 APP/SEMA6A/SEMA6D/NRP1/GOLGA4/SLC6A4/ADRB1/GJA1/LRP1/TGFBR3/YAP1/PRKDC/CDKL5/NRCAM/SPAG9/MACF1/DUSP9/RTN4/EZR/SEMA3F/AFG3L2/LATS2/TGFBR1/RYK/MAPK14/FGFR2/VGLL4/SEMA4B/TNKS2/BCL2/GSK3B/NIPBL/MAP3K13/YY1/PPIB 35 GO:0002934 desmosome organization 5/998 10/18722 8.57500719330278e-05 0.00329192004089955 DSP/PERP/DSG2/GRHL1/PKP2 5 GO:0072080 nephron tubule development 15/998 91/18722 8.74429817369072e-05 0.00333240735509776 MAGED1/LAMA5/LGR4/PBX1/DLG1/CD24/YAP1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 15 GO:0033627 cell adhesion mediated by integrin 13/998 72/18722 9.81056238455009e-05 0.00371166276882145 FBN1/ITGB4/ITGAV/DPP4/ITGB8/ITGB5/ITGB1/PLPP3/FERMT1/EFNA1/SWAP70/JAM3/PTK2 13 GO:2001252 positive regulation of chromosome organization 14/998 82/18722 0.000100873003675926 0.00378890613087778 DNMT1/RAD50/ATRX/MAP3K4/TPR/SFPQ/PKIB/MPHOSPH8/RAD21/CTNNB1/DHX36/TNKS2/PPP1R10/HNRNPA2B1 14 GO:0051180 vitamin transport 10/998 45/18722 0.000102468303506639 0.00382133580434401 LRP2/SLC2A1/SLC19A1/SLC52A1/SLC19A3/FOLR1/SLC5A6/SLC52A3/TTPA/SLC52A2 10 GO:0043434 response to peptide hormone 41/998 414/18722 0.000103244146161803 0.00382296231993458 FBN1/SLC2A1/ATP2B1/DAG1/KANK1/BMP7/GJA1/LRP5/IGF1R/PARP1/TGFBR3/FOXO4/PRKDC/HADHA/GAB1/GGH/MDM2/DENND4C/SRSF5/SLC9A1/LEPROT/BSG/PRKCI/SORBS1/PTPN1/PPARG/CDO1/AHCYL1/ERRFI1/RAB31/GNAI1/USO1/MYO1C/PTK2/SMARCC1/ASS1/STC2/PTPRA/GSK3B/SRSF4/NFE2L2 41 GO:0016331 morphogenesis of embryonic epithelium 20/998 147/18722 0.000106860395070647 0.0039290008638299 LRP2/SPINT1/LAMA5/BMP7/SPINT2/LMO4/TFAP2A/DVL3/FOLR1/HECTD1/COBL/IRX2/TP63/SETD2/FZD6/FGFR2/CTNNB1/GATA3/ST14/ALDH1A3 20 GO:0098876 vesicle-mediated transport to the plasma membrane 19/998 136/18722 0.00011027375878029 0.00399818954577705 GOLGA4/ANK3/EXOC1/CLN3/MACF1/KIAA1109/CLSTN1/CMTM6/RAB31/RAB11FIP4/GOPC/SPTBN1/ACSL3/SNX4/RABEP1/LYPLA1/VPS35/NSG1/KRT18 19 GO:1900180 regulation of protein localization to nucleus 19/998 136/18722 0.00011027375878029 0.00399818954577705 CDH1/MAGED1/TFRC/PARP1/YAP1/FERMT1/GLI3/TPR/LIMK2/FERMT2/CD2AP/LATS2/TRIM29/MAPK14/UBR5/GSK3B/OTUD7B/CTNNA1/LMNA 19 GO:0072088 nephron epithelium morphogenesis 13/998 73/18722 0.000113619055582639 0.00409106958066869 MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 13 GO:0006814 sodium ion transport 28/998 245/18722 0.000120770712485444 0.00429526023413782 SLC6A4/UTRN/SLC13A4/DLG1/SLC38A1/FXYD3/SLC5A3/ANO6/ANK3/MAGED2/ATP2B4/SLC13A3/DMD/PRSS8/ATP6V1B1/SLC9A1/NEDD4/ACTN4/SLC5A6/P2RX4/AHCYL1/SLC22A5/SLC20A2/PKP2/SLC38A2/STOM/GPD1L/SLC38A10 28 GO:0006986 response to unfolded protein 19/998 137/18722 0.00012175799935882 0.00429526023413782 HSPA5/SERPINH1/HSPD1/UBXN4/ERLEC1/CREB3L2/CCND1/STT3B/MBTPS1/UFL1/DNAJB4/PTPN1/HSP90AA1/VCP/EDEM3/HSPA1B/ATF6/NFE2L2/HSPA9 19 GO:0050684 regulation of mRNA processing 19/998 137/18722 0.00012175799935882 0.00429526023413782 MBNL3/RBM39/SON/SF1/DDX17/MBNL2/RBM25/RBM5/FMR1/AHCYL1/TRA2B/DHX36/RBFOX2/ZC3H14/QKI/SRSF4/TIA1/HNRNPU/SRSF2 19 GO:0120192 tight junction assembly 13/998 74/18722 0.000131203733220126 0.00459741403451194 GJA1/DLG1/CLDN4/MPP7/MARVELD3/TJP1/LSR/PARD3/FZD5/MYO1C/CLDN7/OCLN/MARVELD2 13 GO:0031647 regulation of protein stability 32/998 298/18722 0.000134150364622656 0.00466932702463259 TBL1X/CTNND1/AAK1/CALR/PRKDC/RNF128/DDOST/PLPP3/DVL3/HSPD1/MDM2/USP27X/USP47/EFNA1/TRIM44/USP9X/SIAH1/RTN4/HSP90AA1/KRAS/CMTM6/TRIM24/SEL1L/MYLIP/BCL2/HSPA1B/P3H1/CDK7/FLOT2/LMNA/VPS35/PPIB 32 GO:0018279 protein N-linked glycosylation via asparagine 7/998 23/18722 0.000138191331728208 0.0047781254500197 TUSC3/RPN2/FUT8/DDOST/STT3B/STT3A/RPN1 7 GO:0090150 establishment of protein localization to membrane 29/998 260/18722 0.000141363755943696 0.00485565901172394 EGFR/TCAF1/GOLGA4/HSPA5/CCDC47/ANK3/CD24/SIL1/EMC1/CLN3/MACF1/PRKCI/PARD3/TRAM2/CLSTN1/SEC63/HSP90AA1/RAB31/MYO1C/GOPC/SPTBN1/ACSL3/STOM/EMC10/EMC7/LYPLA1/VPS35/NSG1/KRT18 29 GO:0006487 protein N-linked glycosylation 12/998 65/18722 0.000144609133879062 0.00493466854890576 TUSC3/RPN2/FUT8/DDOST/GFPT1/B4GALT1/STT3B/TMEM165/MOGS/EXT2/STT3A/RPN1 12 GO:0001656 metanephros development 14/998 85/18722 0.000150263836163088 0.00506226267387576 FBN1/BMP7/DLG5/LGR4/NF1/YAP1/FRAS1/GLI3/IRX2/CTNNB1/GATA3/BCL2/NIPBL/GPC3 14 GO:0050885 neuromuscular process controlling balance 10/998 47/18722 0.000150966735192399 0.00506226267387576 APP/HEXB/IGDCC3/MYO7A/CLN3/SLC1A3/GM2A/GAA/ALDH1A3/RBFOX2 10 GO:1905477 positive regulation of protein localization to membrane 16/998 106/18722 0.000151257034500023 0.00506226267387576 EGFR/TCAF1/ITGB1/DLG1/SLC5A3/ANK3/LRP1/ATP2B4/CLN3/EZR/PRKCI/SORBS1/MYO1C/SPTBN1/ACSL3/STOM 16 GO:1903828 negative regulation of cellular protein localization 17/998 117/18722 0.000153588982982497 0.00510756738950075 MAGED1/LMAN1/CLTC/FERMT1/HECTD1/ERLEC1/PPFIA1/LEPROT/TMEM59/LATS2/TRIM29/GOPC/GSK3B/OTUD7B/CTNNA1/LYPLA1/UBE2G2 17 GO:0044409 entry into host 20/998 151/18722 0.000155205950620259 0.00512867258347072 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/P4HB/CD55/SLC52A1/BSG/SLC1A5/UVRAG/SLC20A2/WWP1/HSPA1B/SLC52A2 20 GO:0050769 positive regulation of neurogenesis 26/998 225/18722 0.000174169299821755 0.00571910637968165 EGFR/LRP2/SPINT1/MME/DAG1/NRP1/GOLGA4/SERPINF1/TGM2/LRP1/CUX1/IL6ST/OBSL1/GLI3/PLXNB1/CDKL5/MACF1/UFL1/PRKCI/DICER1/CTNNB1/DHX36/PLXNA1/MAN2A1/MAP3K13/HDAC2 26 GO:0032527 protein exit from endoplasmic reticulum 10/998 48/18722 0.00018168761908671 0.00591326065036985 HSP90B1/ERLEC1/BCAP31/VCP/TM9SF4/TMEM30B/GCC2/SEL1L/TMEM30A/UBE2G2 10 GO:0015849 organic acid transport 32/998 303/18722 0.000182347244725061 0.00591326065036985 LRP2/SLC26A2/SLC2A1/SLC27A2/ITGB1/GJA1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC19A1/SLC13A3/FOLR1/CROT/SLC7A6/SLC16A1/SLC16A2/CLN3/SLC1A5/SLC7A2/SLC1A3/PLA2R1/SLC5A6/P2RX4/PPARG/CPT2/SLC38A2/SLC17A5/ABCB1/ACSL3/SERINC3/SLC38A10 32 GO:0034504 protein localization to nucleus 31/998 290/18722 0.000184040493383953 0.00591638104914886 CDH1/MAGED1/BMP7/TFRC/PARP1/CALR/YAP1/TOR1AIP2/PTTG1IP/MDM2/FERMT1/GLI3/TNPO1/TPR/LIMK2/FERMT2/CD2AP/LATS2/TRIM29/MAPK14/SUN1/RANBP17/IPO7/RANBP2/UBR5/GSK3B/OTUD7B/PPP1R10/CTNNA1/LMNA/HNRNPU 31 GO:0110053 regulation of actin filament organization 30/998 277/18722 0.000184709846966341 0.00591638104914886 MET/KANK1/NRP1/RASA1/DLG1/IQGAP2/LIMA1/CD47/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/SWAP70/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/PHLDB2 30 GO:0018196 peptidyl-asparagine modification 7/998 24/18722 0.000186166471661707 0.0059266777350352 TUSC3/RPN2/FUT8/DDOST/STT3B/STT3A/RPN1 7 GO:0010631 epithelial cell migration 36/998 357/18722 0.000187683379534822 0.00593875711849275 MET/NRP2/KANK1/NRP1/DPP4/SERPINF1/ITGB1/NR2F2/NF1/AMOT/CALR/EPHB4/PLPP3/ATP2B4/TACSTD2/FSTL1/FERMT1/EFNA1/MACF1/MARVELD3/RTN4/TGFBR1/P2RX4/MIA3/PPARG/PIK3CB/PKN2/PTPRM/DOCK1/PTK2/GATA3/PLK2/LGALS8/EMC10/ANXA3/NFE2L2 36 GO:0046661 male sex differentiation 21/998 165/18722 0.00018963316592689 0.00596121577453115 LRP2/ADGRG1/LGR4/RHOBTB3/CTSV/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/DHCR24/TGFBR1/ARID5B/PLEKHA1/CTNNB1/MMP14/GATA3/BCL2/TMF1/CTNNA1 21 GO:0019058 viral life cycle 33/998 317/18722 0.000190676696867784 0.00596121577453115 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/DDB1/HACD3/P4HB/CD55/EEA1/SLC52A1/BSG/SLC1A5/MPHOSPH8/FMR1/NEDD4/TOP2B/UVRAG/PKN2/EIF2AK4/VCP/SLC20A2/WWP1/BCL2/HSPA1B/STOM/SLC52A2/PPIB 33 GO:0007029 endoplasmic reticulum organization 14/998 87/18722 0.000193756674516786 0.00602144998602465 LMAN1/CCDC47/TOR1AIP2/LPCAT3/SEC31A/EMC1/REEP3/RTN4/TRAM2/MIA3/ESYT2/EMC10/EMC7/REEP5 14 GO:0014037 Schwann cell differentiation 9/998 40/18722 0.000205055063641452 0.00626077477936854 ITGB4/DAG1/NF1/ERBB3/DICER1/PARD3/ADGRG6/PLEC/GPC1 9 GO:0035329 hippo signaling 9/998 40/18722 0.000205055063641452 0.00626077477936854 DLG5/AMOT/YAP1/TEAD1/LATS2/AMOTL1/MAPK14/VGLL4/SHANK2 9 GO:0071526 semaphorin-plexin signaling pathway 9/998 40/18722 0.000205055063641452 0.00626077477936854 MET/NRP2/SEMA6A/SEMA6D/NRP1/PLXNB1/SEMA3F/SEMA4B/PLXNA1 9 GO:0051897 positive regulation of protein kinase B signaling 17/998 120/18722 0.000209964144719778 0.00637338836966255 EGFR/LRP2/MET/ITGB1/IGF1R/GCNT2/FERMT2/RTN4/TPBG/TGFBR1/P2RX4/HSP90AA1/PIK3CB/TCF7L2/PTK2/GATA3/ARFGEF1 17 GO:0007435 salivary gland morphogenesis 8/998 32/18722 0.000211917999037266 0.00639551371661021 DAG1/NRP1/LAMA5/BMP7/TGM2/FGFR2/PLXNA1/BTBD7 8 GO:0034332 adherens junction organization 10/998 49/18722 0.000217497477470133 0.00652617430960668 DSP/CDH1/DLG5/FERMT2/TJP1/JAM3/CTNNB1/KIFC3/RDX/PLEC 10 GO:0090132 epithelium migration 36/998 360/18722 0.000221055000006173 0.00659501802875559 MET/NRP2/KANK1/NRP1/DPP4/SERPINF1/ITGB1/NR2F2/NF1/AMOT/CALR/EPHB4/PLPP3/ATP2B4/TACSTD2/FSTL1/FERMT1/EFNA1/MACF1/MARVELD3/RTN4/TGFBR1/P2RX4/MIA3/PPARG/PIK3CB/PKN2/PTPRM/DOCK1/PTK2/GATA3/PLK2/LGALS8/EMC10/ANXA3/NFE2L2 36 GO:1904888 cranial skeletal system development 12/998 68/18722 0.000225704450865411 0.0066954712384563 TFAP2A/GLI3/TP63/TGFBR1/SETD2/MSX2/IRF6/SLC39A1/FGFR2/CTNNB1/MMP14/NIPBL 12 GO:0001704 formation of primary germ layer 17/998 121/18722 0.000232390767182887 0.00685487116080144 LAMB1/ITGB4/WLS/ITGAV/BMP7/ITGB5/ITGB1/GJA1/COL4A2/MMP15/SETD2/FGFR2/CTNNB1/MMP14/EXT2/COL5A2/DUSP5 17 GO:0098911 regulation of ventricular cardiac muscle cell action potential 5/998 12/18722 0.000246360629566977 0.00722611711780441 DSP/DSC2/DLG1/DSG2/PKP2 5 GO:0090303 positive regulation of wound healing 11/998 59/18722 0.000247878429718265 0.00723001833273218 KANK1/ITGB1/CLDN4/ANO6/PLPP3/FERMT1/FERMT2/PTK2/ARFGEF1/OCLN/NFE2L2 11 GO:0060348 bone development 24/998 205/18722 0.000250252437789515 0.00725871098721699 FBN1/GJA1/LRP5/BBX/GLG1/TGM2/TRIP11/SERPINH1/TFAP2A/GLI3/HSD17B1/PLXNB1/WASF2/MSX2/MAPK14/FGFR2/MMP14/EXT2/LTBP3/P3H1/SLC38A10/PPIB/ANXA2/GNAS 24 GO:0042552 myelination 18/998 134/18722 0.000272649984134869 0.007864671641813 ITGB4/DAG1/DEGS1/DLG1/NF1/HEXB/EPB41L3/NCSTN/AFG3L2/CMTM8/DICER1/PARD3/JAM3/CTNNB1/ADGRG6/PLEC/QKI/GPC1 18 GO:0008380 RNA splicing 41/998 434/18722 0.000282617734823235 0.00810740216215444 MBNL3/AHNAK/FUS/RBM39/SON/ZC3H13/SF1/SRSF5/DDX17/PNN/SRRM2/MBNL2/RBM25/SFPQ/ESRP1/SRSF11/RBM5/FMR1/PAXBP1/ZNF638/TRA2B/SF3B1/DDX1/TCERG1/SLC38A2/SNRNP200/SREK1/RBFOX2/SUGP2/PRPF8/RBM6/POLR2A/QKI/PRPF4B/PRPF40A/SRSF4/TIA1/HNRNPU/LUC7L3/SRSF2/HNRNPA2B1 41 GO:0090130 tissue migration 36/998 365/18722 0.000288619107954904 0.00823431892148937 MET/NRP2/KANK1/NRP1/DPP4/SERPINF1/ITGB1/NR2F2/NF1/AMOT/CALR/EPHB4/PLPP3/ATP2B4/TACSTD2/FSTL1/FERMT1/EFNA1/MACF1/MARVELD3/RTN4/TGFBR1/P2RX4/MIA3/PPARG/PIK3CB/PKN2/PTPRM/DOCK1/PTK2/GATA3/PLK2/LGALS8/EMC10/ANXA3/NFE2L2 36 GO:0032204 regulation of telomere maintenance 13/998 80/18722 0.000294034343942064 0.00834322450935608 PARP1/RAD50/ATRX/MAP3K4/DCP2/PKIB/CTNNB1/DHX36/TNKS2/YLPM1/PPP1R10/HNRNPU/HNRNPA2B1 13 GO:0002064 epithelial cell development 25/998 220/18722 0.000298156039219882 0.00837622152706017 MET/ADAMTSL4/SPINT2/CDK6/EXPH5/YAP1/IL6ST/TFCP2L1/B4GALT1/ATRX/MYO7A/KLF5/FAT1/TP63/TJP1/S1PR2/EZR/TRIOBP/RDX/ST14/YIPF6/PLEC/GSK3B/FASN/MARVELD2 25 GO:0070830 bicellular tight junction assembly 12/998 70/18722 0.000298998102933278 0.00837622152706017 GJA1/DLG1/CLDN4/MPP7/MARVELD3/TJP1/PARD3/FZD5/MYO1C/CLDN7/OCLN/MARVELD2 12 GO:0009896 positive regulation of catabolic process 45/998 492/18722 0.000300010232821347 0.00837622152706017 LRP2/APP/KCNQ1OT1/GJA1/DDB1/LRP1/LIN28B/RNF128/PTTG1IP/MDM2/RNF217/HECTD1/HUWE1/PUM1/UFL1/DCP2/TMEM59/EZR/FMR1/NEDD4/TMTC3/PTPN1/HSP90AA1/PIK3CB/BCAP31/UVRAG/VCP/VGLL4/DHX36/WWP1/AGO2/NRDC/SH3D19/RDX/MYLIP/PTK2/PLK2/TNRC6A/HSPA1B/GSK3B/GPC3/ATF6/VPS35/NFE2L2/TMEM259 45 GO:0051962 positive regulation of nervous system development 29/998 272/18722 0.000306018046695033 0.0084749699964338 EGFR/LRP2/SPINT1/MME/DAG1/NRP1/GOLGA4/SERPINF1/DLG5/TGM2/LRP1/CUX1/IL6ST/OBSL1/GLI3/PLXNB1/CDKL5/MACF1/UFL1/PRKCI/TPBG/DICER1/CLSTN1/CTNNB1/DHX36/PLXNA1/MAN2A1/MAP3K13/HDAC2 29 GO:0003007 heart morphogenesis 27/998 246/18722 0.000306793589221603 0.0084749699964338 LRP2/DSP/NRP2/NRP1/BMP7/GJA5/ADAMTS1/TGFBR3/YAP1/EPHB4/MDM2/FOLR1/ISL1/EFNA1/AHI1/RTN4/TGFBR1/FGFR2/CTNNB1/PKP2/GAA/PTK2/ADGRG6/PPP1R13L/GATA3/PDCD4/NIPBL 27 GO:0048545 response to steroid hormone 34/998 339/18722 0.000309353916753291 0.0085007199966786 EGFR/AGL/ATP2B1/BMP7/SERPINF1/CLDN4/PARP1/CALR/YAP1/IDH1/CTSV/SKP2/HSPD1/MDM2/ISL1/ESRRG/DDX17/RBBP7/CCND1/TP63/UFL1/NEDD4/KRAS/CDO1/ERRFI1/BCL2/UBR5/ASS1/RBFOX2/TMF1/ALAD/ANXA3/GLB1/HNRNPU 34 GO:0035966 response to topologically incorrect protein 20/998 159/18722 0.0003124150239481 0.00853988921483262 HSPA5/SERPINH1/HSPD1/UBXN4/ERLEC1/DNAJB14/CREB3L2/CCND1/STT3B/MBTPS1/UFL1/DNAJB4/PTPN1/HSP90AA1/VCP/EDEM3/HSPA1B/ATF6/NFE2L2/HSPA9 20 GO:0060669 embryonic placenta morphogenesis 7/998 26/18722 0.00032222442839283 0.00873920539746247 SPINT1/BMP7/SPINT2/SETD2/FGFR2/FZD5/ST14 7 GO:0048588 developmental cell growth 26/998 234/18722 0.000324884105336279 0.00873920539746247 APP/NRP2/SEMA6A/SEMA6D/NRP1/GOLGA4/ITGB1/LRP1/COBL/CDKL5/USP9X/NRCAM/SPAG9/MACF1/RTN4/SEMA3F/HSP90AA1/RYK/EIF2AK4/CTNNB1/SEMA4B/DDR1/PLXNA1/GSK3B/MAP3K13/YY1 26 GO:0050673 epithelial cell proliferation 41/998 437/18722 0.000325943535352288 0.00873920539746247 EGFR/NRP2/LAMB1/LGR5/LAMC1/MAGED1/NRP1/SERPINF1/GJA1/LGR4/NR2F2/DLG1/CDK6/NF1/TGFBR3/YAP1/PRKDC/ISL1/B4GALT1/FERMT1/KDM5B/CCND1/TP63/MARVELD3/NCSTN/RTN4/TGFBR1/SUZ12/PPARG/PURA/IRF6/ERRFI1/PTPRM/FGFR2/CDKN1C/CTNNB1/TCF7L2/MMP14/GATA3/GPC3/EMC10 41 GO:0007272 ensheathment of neurons 18/998 136/18722 0.000328075896935959 0.00873920539746247 ITGB4/DAG1/DEGS1/DLG1/NF1/HEXB/EPB41L3/NCSTN/AFG3L2/CMTM8/DICER1/PARD3/JAM3/CTNNB1/ADGRG6/PLEC/QKI/GPC1 18 GO:0008366 axon ensheathment 18/998 136/18722 0.000328075896935959 0.00873920539746247 ITGB4/DAG1/DEGS1/DLG1/NF1/HEXB/EPB41L3/NCSTN/AFG3L2/CMTM8/DICER1/PARD3/JAM3/CTNNB1/ADGRG6/PLEC/QKI/GPC1 18 GO:0086004 regulation of cardiac muscle cell contraction 8/998 34/18722 0.000332716520565942 0.00878529792700489 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/PKP2/ATP2A2 8 GO:0034113 heterotypic cell-cell adhesion 11/998 61/18722 0.000335969954241717 0.00878529792700489 DSP/DSC2/ITGAV/BMP7/PERP/ITGB1/DSG2/GCNT2/CD47/JAM3/PKP2 11 GO:0006491 N-glycan processing 6/998 19/18722 0.000336536982455655 0.00878529792700489 FUT8/GANAB/MAN1A2/GNPTAB/MAN2A1/PRKCSH 6 GO:0007039 protein catabolic process in the vacuole 6/998 19/18722 0.000336536982455655 0.00878529792700489 LRP2/LRP1/RNF128/CLN3/VPS13A/TMEM106B 6 GO:0042063 gliogenesis 31/998 301/18722 0.000354931094813372 0.00918518724357705 EGFR/LRP2/APP/SPINT1/LAMB1/ADGRG1/ITGB4/DAG1/CDK6/NF1/LRP1/HEXB/IL6ST/ERBB3/GLI3/UFL1/NCSTN/RTN4/PRKCI/DICER1/P2RX4/PARD3/KRAS/CTNNB1/SUN1/MMP14/ADGRG6/GPR157/PLEC/GPC1/HDAC2 31 GO:0007369 gastrulation 22/998 185/18722 0.000357849794580008 0.00918518724357705 LAMB1/ITGB4/WLS/DAG1/ITGAV/BMP7/ITGB5/ITGB1/GJA1/LRP5/AMOT/COL4A2/MMP15/SETD2/FGFR2/CTNNB1/MMP14/EXT2/COL5A2/PHLDB2/GPC3/DUSP5 22 GO:0007623 circadian rhythm 24/998 210/18722 0.000358786039953507 0.00918518724357705 EGFR/MAGED1/SLC6A4/ADRB1/DDB1/LGR4/CLDN4/PRKDC/OPN3/GFPT1/ZFHX3/HUWE1/USP9X/SFPQ/SIAH2/MYCBP2/PPARG/BHLHE41/NR2F6/GPR157/ASS1/GSK3B/HDAC2/HNRNPU 24 GO:0003279 cardiac septum development 15/998 103/18722 0.000358892587184393 0.00918518724357705 LRP2/NRP2/ADAMTS6/NRP1/BMP7/LMO4/GJA5/TGFBR3/TRIP11/MDM2/ISL1/HECTD1/TGFBR1/FGFR2/GATA3 15 GO:0021545 cranial nerve development 10/998 52/18722 0.000362212714122562 0.00922493941675072 NRP2/NRP1/TFAP2A/ERBB3/ISL1/GLI3/SEMA3F/SLC1A3/NAV2/CTNNB1 10 GO:0003205 cardiac chamber development 20/998 161/18722 0.000368736835556091 0.00934550979824443 LRP2/DSP/NRP2/ADAMTS6/NRP1/BMP7/LMO4/GJA5/ADAMTS1/TGFBR3/TRIP11/MDM2/ISL1/HECTD1/TGFBR1/FGFR2/PKP2/ADGRG6/PPP1R13L/GATA3 20 GO:1905897 regulation of response to endoplasmic reticulum stress 13/998 82/18722 0.000377260182539395 0.00951534015960475 HSPA5/USP25/LPCAT3/UFL1/ERP29/PTPN1/BCAP31/SERINC3/ATF6/PMAIP1/NFE2L2/USP14/TMEM259 13 GO:0060670 branching involved in labyrinthine layer morphogenesis 5/998 13/18722 0.000382799490498111 0.00955245860284874 SPINT1/SPINT2/FGFR2/FZD5/ST14 5 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 5/998 13/18722 0.000382799490498111 0.00955245860284874 NRP2/NRP1/PLXNB1/SEMA3F/PLXNA1 5 GO:0060675 ureteric bud morphogenesis 11/998 62/18722 0.000389054287941126 0.00955245860284874 MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/CTNNB1/GATA3/BCL2/GPC3 11 GO:1903078 positive regulation of protein localization to plasma membrane 11/998 62/18722 0.000389054287941126 0.00955245860284874 EGFR/ITGB1/DLG1/LRP1/ATP2B4/CLN3/EZR/PRKCI/SORBS1/SPTBN1/ACSL3 11 GO:0032956 regulation of actin cytoskeleton organization 35/998 357/18722 0.000389522827210024 0.00955245860284874 MET/KANK1/NRP1/RASA1/DLG1/RHOBTB3/LRP1/IQGAP2/LIMA1/CD47/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/CD2AP/TJP1/TGFBR1/SWAP70/TRIOBP/JAM3/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/RND3/ARFGEF1/ADD3/PHLDB2 35 GO:0007548 sex differentiation 29/998 276/18722 0.000390317896992759 0.00955245860284874 LRP2/ADGRG1/HSPA5/LGR4/PBX1/NR2F2/ADAMTS1/RHOBTB3/IDH1/CTSV/ZFX/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/TP63/DHCR24/TGFBR1/ARID5B/PLEKHA1/CTNNB1/MMP14/GATA3/BCL2/NIPBL/TMF1/CTNNA1 29 GO:1903036 positive regulation of response to wounding 12/998 72/18722 0.000391539195749785 0.00955245860284874 KANK1/ITGB1/CLDN4/ANO6/LRP1/PLPP3/FERMT1/FERMT2/PTK2/ARFGEF1/OCLN/NFE2L2 12 GO:0048568 embryonic organ development 40/998 427/18722 0.000395496226555807 0.00960411999464124 FBN2/FBN1/SPINT1/EFEMP1/BMP7/SPINT2/PBX1/NR2F2/DLG1/YAP1/TFAP2A/TEAD1/FOLR1/HECTD1/EFNA1/GLI3/COBL/BPTF/ATP6V1B1/MYO7A/RAD23B/AHI1/BIRC6/TGFBR1/SETD2/TRIOBP/FZD6/SLC39A1/FGFR2/TRA2B/CTNNB1/FZD5/MMP14/PPP1R13L/GATA3/ST14/ALDH1A3/NIPBL/MYO6/PHLDA2 40 GO:0006892 post-Golgi vesicle-mediated transport 15/998 104/18722 0.000399110897906359 0.00962579450648698 GOLGA4/ANK3/EXOC1/CLN3/MACF1/VPS13A/SCAMP2/RAB31/GOPC/RP2/SPTBN1/ACSL3/RABEP1/LYPLA1/KRT18 15 GO:0051494 negative regulation of cytoskeleton organization 20/998 162/18722 0.00040007611720124 0.00962579450648698 MET/KANK1/LIMA1/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/TJP1/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/PHLDB2 20 GO:0010765 positive regulation of sodium ion transport 8/998 35/18722 0.000411353122870999 0.00980673358223509 ANK3/DMD/PRSS8/SLC9A1/ACTN4/AHCYL1/PKP2/GPD1L 8 GO:0035633 maintenance of blood-brain barrier 8/998 35/18722 0.000411353122870999 0.00980673358223509 LAMC1/ITGB1/GJA1/DMD/TJP1/LSR/JAM3/OCLN 8 GO:0070861 regulation of protein exit from endoplasmic reticulum 7/998 27/18722 0.000415148951764594 0.00985223944164974 ERLEC1/BCAP31/TM9SF4/TMEM30B/GCC2/TMEM30A/UBE2G2 7 GO:0008347 glial cell migration 10/998 53/18722 0.000425415567325263 0.0100408014583135 LAMB1/ADGRG1/LRP1/HEXB/GLI3/RTN4/P2RX4/CTNNB1/SUN1/MMP14 10 GO:0052126 movement in host environment 21/998 175/18722 0.000426940801330321 0.0100408014583135 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/DDB1/P4HB/CD55/SLC52A1/BSG/SLC1A5/UVRAG/SLC20A2/WWP1/HSPA1B/SLC52A2 21 GO:0060485 mesenchyme development 30/998 291/18722 0.000431280177664624 0.0100973713344709 NRP2/SEMA6A/SEMA6D/DAG1/NRP1/LAMA5/BMP7/DLG5/GCNT2/TGFBR3/YAP1/MDM2/FOLR1/ISL1/EFNA1/DDX17/FERMT2/RTN4/SEMA3F/TGFBR1/FGFR2/CTNNB1/SEMA4B/TCF7L2/GATA3/BCL2/PDCD4/GSK3B/PHLDB2/HDAC2 30 GO:0072171 mesonephric tubule morphogenesis 11/998 63/18722 0.000448999341765759 0.0104652926935671 MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/CTNNB1/GATA3/BCL2/GPC3 11 GO:0010975 regulation of neuron projection development 41/998 445/18722 0.000471949615990299 0.0109513286448238 ITGA6/TENM3/SEMA6A/SEMA6D/KANK1/NRP1/GOLGA4/BMP7/SERPINF1/HSPA5/LRP1/CUX1/CAMK2G/MDM2/PPP1R9A/OBSL1/EFNA1/PLXNB1/COBL/CDKL5/CREB3L2/MACF1/RTN4/SEMA3F/PRKCI/NEDD4/KIDINS220/CAMSAP2/RYK/TMEM106B/DHX36/SEMA4B/PLXNA1/MYLIP/GATA3/TMEM30A/P3H1/GSK3B/MAP3K13/HDAC2/NFE2L2 41 GO:0030516 regulation of axon extension 14/998 95/18722 0.00049326731199822 0.0113953479466492 SEMA6A/SEMA6D/NRP1/GOLGA4/LRP1/CDKL5/NRCAM/MACF1/RTN4/SEMA3F/RYK/SEMA4B/GSK3B/MAP3K13 14 GO:0001706 endoderm formation 10/998 54/18722 0.000497517290790366 0.0114428976881784 LAMB1/ITGAV/ITGB5/COL4A2/MMP15/SETD2/CTNNB1/MMP14/COL5A2/DUSP5 10 GO:0007040 lysosome organization 12/998 74/18722 0.000507181354142209 0.0115632919212946 HEXB/ABCA1/SYT7/HOOK2/MYO7A/CLN3/MBTPS1/TMEM106B/TMEM165/GNPTAB/GAA/AKTIP 12 GO:0080171 lytic vacuole organization 12/998 74/18722 0.000507181354142209 0.0115632919212946 HEXB/ABCA1/SYT7/HOOK2/MYO7A/CLN3/MBTPS1/TMEM106B/TMEM165/GNPTAB/GAA/AKTIP 12 GO:0008584 male gonad development 18/998 141/18722 0.000511276494800875 0.0116059764319799 LRP2/ADGRG1/RHOBTB3/CTSV/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/TGFBR1/ARID5B/PLEKHA1/MMP14/GATA3/BCL2/TMF1/CTNNA1 18 GO:0030835 negative regulation of actin filament depolymerization 9/998 45/18722 0.000523084251775043 0.0117716503384375 LIMA1/SCIN/SWAP70/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 9 GO:0035987 endodermal cell differentiation 9/998 45/18722 0.000523084251775043 0.0117716503384375 LAMB1/ITGAV/ITGB5/COL4A2/MMP15/SETD2/CTNNB1/MMP14/COL5A2 9 GO:0030203 glycosaminoglycan metabolic process 16/998 118/18722 0.000525885044547668 0.0117838876291132 ITIH5/CLTC/CHPF/GCNT2/HEXB/FUCA1/HS6ST2/B3GNT3/GLCE/HEXA/B3GNT2/GUSB/EXT2/GNS/B4GAT1/GLB1 16 GO:0032801 receptor catabolic process 7/998 28/18722 0.000528290141967957 0.0117871915863876 RNF43/ZNRF3/NEDD4/PTPN1/UVRAG/MYLIP/ANXA2 7 GO:0040013 negative regulation of locomotion 37/998 391/18722 0.000531541106996397 0.0118092600835242 CDH1/TCAF1/ADGRG1/SEMA6A/SEMA6D/DAG1/KANK1/FBLN1/NRP1/DPP4/SERPINF1/DLG5/GJA1/SPINT2/NR2F2/NF1/LRP1/CALR/GNA12/ATP2B4/TACSTD2/CCDC125/MARVELD3/STK26/S1PR2/SEMA3F/MIA3/PPARG/RYK/PTPRM/SEMA4B/GATA3/BCL2/SRGAP1/PHLDB2/CTNNA1/NFE2L2 37 GO:0043112 receptor metabolic process 20/998 166/18722 0.000549779276646321 0.0121113822927023 RNF43/TFRC/ITGB1/LRPAP1/LRP1/CLTC/FUT8/ZNRF3/AHI1/EZR/FMR1/NEDD4/PTPN1/UVRAG/RAB31/MYLIP/ATXN2/OPHN1/NSG1/ANXA2 20 GO:1902904 negative regulation of supramolecular fiber organization 20/998 166/18722 0.000549779276646321 0.0121113822927023 MET/KANK1/LIMA1/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/TJP1/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/PHLDB2 20 GO:0046546 development of primary male sexual characteristics 18/998 142/18722 0.000556977432963746 0.0121726625645351 LRP2/ADGRG1/RHOBTB3/CTSV/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/TGFBR1/ARID5B/PLEKHA1/MMP14/GATA3/BCL2/TMF1/CTNNA1 18 GO:0008360 regulation of cell shape 19/998 154/18722 0.000557223971063759 0.0121726625645351 MYH10/DAG1/RASA1/DLG1/RHOBTB3/BRWD1/HEXB/FMNL2/PLXNB1/FERMT2/EPB41L3/EZR/ARHGAP18/RDX/PLXNA1/PTK2/EPS8/RND3/PRPF40A 19 GO:0001755 neural crest cell migration 10/998 55/18722 0.000579460196566858 0.0125533679928447 NRP2/SEMA6A/SEMA6D/NRP1/LAMA5/BMP7/FOLR1/ISL1/SEMA3F/SEMA4B 10 GO:0098900 regulation of action potential 10/998 55/18722 0.000579460196566858 0.0125533679928447 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/SLC9A1/FMR1/PKP2/ATP2A2 10 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 14/998 97/18722 0.000611527600796002 0.0131401623095776 ITGA6/NRP1/ITGAV/IFI6/YAP1/SIAH2/BIRC6/TGFBR1/TCF7L2/BCL2/HSPA1B/GSK3B/CTNNA1/LMNA 14 GO:0099515 actin filament-based transport 6/998 21/18722 0.000614096840363326 0.0131401623095776 SYNE2/FNBP1L/MYO7A/ACTN4/MYO1C/MYO6 6 GO:2000178 negative regulation of neural precursor cell proliferation 6/998 21/18722 0.000614096840363326 0.0131401623095776 SPINT1/SLC6A4/SPINT2/NF1/SLC16A2/CTNNA1 6 GO:0006984 ER-nucleus signaling pathway 9/998 46/18722 0.000619978529947422 0.0132118689994102 HSPA5/CCDC47/LPCAT3/MBTPS1/PTPN1/ATP2A2/GSK3B/ATF6/NFE2L2 9 GO:0045785 positive regulation of cell adhesion 40/998 437/18722 0.000625802329850746 0.0132817640819136 ITGA6/CD46/ADGRG1/DAG1/NRP1/ITGAV/BMP7/UTRN/DPP4/CCDC80/TFRC/NFAT5/P4HB/CDK6/CD55/TGM2/ANK3/CD24/GCNT2/CALR/CD47/PLPP3/IL6ST/VAV3/HSPD1/FERMT1/GLI3/ZFHX3/FERMT2/DOCK8/TJP1/YES1/CYTH3/TRIOBP/DOCK1/NEDD9/GATA3/GSK3B/FLOT2/PNP 40 GO:0031346 positive regulation of cell projection organization 34/998 353/18722 0.000643276909105318 0.013597363329712 ITGA6/TENM3/NRP1/GOLGA4/BMP7/SERPINF1/HSPA5/LRP1/CUX1/FNBP1L/DVL3/PPP1R9A/OBSL1/ATMIN/PLXNB1/COBL/CDKL5/WASF2/CREB3L2/MACF1/PRKCI/FMR1/TGFBR1/KIDINS220/TMEM106B/DHX36/PLXNA1/NCKAP1/EPS8/TMEM30A/OCLN/P3H1/MAP3K13/NFE2L2 34 GO:0086001 cardiac muscle cell action potential 12/998 76/18722 0.0006502927312636 0.0136902352819647 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/ANK3/DMD/PKP2/ATP2A2/GPD1L 12 GO:0045667 regulation of osteoblast differentiation 17/998 132/18722 0.00065332857984375 0.0136989097002579 FBN2/CRIM1/BMP7/CDK6/LRP5/SUCO/YAP1/SMOC1/IL6ST/GLI3/FERMT2/TP63/PPARG/FGFR2/CTNNB1/PTK2/ATRAID 17 GO:0032271 regulation of protein polymerization 25/998 232/18722 0.000661475616034473 0.0137160509974436 MET/KANK1/RASA1/CLIP1/AKAP9/DLG1/IQGAP2/KANK4/SCIN/PPP1R9A/WASF2/CAMSAP2/TRIOBP/HSP90AA1/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/OCLN/HSPA1B/ADD3 25 GO:0072009 nephron epithelium development 15/998 109/18722 0.000663237285715249 0.0137160509974436 MAGED1/LAMA5/LGR4/PBX1/DLG1/CD24/YAP1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 15 GO:0022011 myelination in peripheral nervous system 7/998 29/18722 0.000664654453620613 0.0137160509974436 ITGB4/DAG1/NF1/DICER1/PARD3/ADGRG6/PLEC 7 GO:0032292 peripheral nervous system axon ensheathment 7/998 29/18722 0.000664654453620613 0.0137160509974436 ITGB4/DAG1/NF1/DICER1/PARD3/ADGRG6/PLEC 7 GO:0001658 branching involved in ureteric bud morphogenesis 10/998 56/18722 0.000672249814513019 0.0137602210285148 MAGED1/LAMA5/LGR4/PBX1/DLG1/TACSTD2/GLI3/CTNNB1/BCL2/GPC3 10 GO:0031122 cytoplasmic microtubule organization 10/998 56/18722 0.000672249814513019 0.0137602210285148 CLIP1/DST/DLG1/SLK/DYNC1H1/HOOK2/LIMK2/EZR/CAMSAP2/PCM1 10 GO:1902903 regulation of supramolecular fiber organization 36/998 382/18722 0.000677156038023066 0.0137602210285148 APP/MET/KANK1/NRP1/RASA1/CLIP1/AKAP9/DLG1/IQGAP2/LIMA1/CD47/KANK4/SCIN/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/SWAP70/CAMSAP2/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/OCLN/HSPA1B/ADD3/PHLDB2 36 GO:0016049 cell growth 43/998 482/18722 0.000677337062694561 0.0137602210285148 EGFR/APP/NRP2/SEMA6A/SEMA6D/NRP1/GOLGA4/SMARCA2/ITGB1/GJA1/LRP1/NET1/USP47/RBBP7/COBL/CDKL5/USP9X/NRCAM/SPAG9/SLC9A1/MACF1/EIF4G1/EPB41L3/RTN4/SEMA3F/KIAA1109/TGFBR1/DCBLD2/CLSTN1/HSP90AA1/RYK/EIF2AK4/VGLL4/CTNNB1/SEMA4B/MMP14/DDR1/PLXNA1/BCL2/HSPA1B/GSK3B/MAP3K13/YY1 43 GO:0044706 multi-multicellular organism process 24/998 220/18722 0.000705346201788376 0.0141630715818527 ITGB4/SLC2A1/FBLN1/SLC6A4/STS/GJA1/NR2F2/CLDN4/SLC38A1/PRLR/CALR/MAGED2/SLC19A1/CTSV/HEXB/ASH1L/B4GALT1/BSG/KRAS/SLC38A2/AGO2/DDR1/BCL2/STC2 24 GO:0048705 skeletal system morphogenesis 24/998 220/18722 0.000705346201788376 0.0141630715818527 FBN2/BMP7/DLG1/LRP5/GLG1/TRIP11/SERPINH1/TFAP2A/GLI3/ANKRD11/TGFBR1/SETD2/MSX2/RYK/SLC39A1/MAPK14/FGFR2/ARID5B/PLEKHA1/CTNNB1/MMP14/EXT2/LTBP3/NIPBL 24 GO:0001837 epithelial to mesenchymal transition 19/998 157/18722 0.000708057255727455 0.0141630715818527 DAG1/BMP7/DLG5/GCNT2/TGFBR3/ISL1/EFNA1/DDX17/FERMT2/RTN4/TGFBR1/FGFR2/CTNNB1/TCF7L2/GATA3/PDCD4/GSK3B/PHLDB2/HDAC2 19 GO:0007030 Golgi organization 19/998 157/18722 0.000708057255727455 0.0141630715818527 GOLGB1/LMAN1/AKAP9/PDE4DIP/TMED4/TRIP11/ARHGAP21/OBSL1/HUWE1/TMED9/CAMSAP2/SURF4/GCC2/USO1/KIFC3/GOLGA2/ARFGEF1/ARL1/TMED1 19 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 34/998 355/18722 0.000710730655898373 0.0141630715818527 FBN2/FBN1/LRP2/PEG10/CRIM1/BMP7/ITGB8/HSPA5/ITGB5/GLG1/LRP1/PARP1/GCNT2/TGFBR3/FUT8/ZNF451/TRIM33/FOLR1/FSTL1/FERMT1/USP9X/FERMT2/NREP/LATS2/TGFBR1/PPARG/MAPK14/CDKN1C/PTK2/SPTBN1/PDCD4/LTBP3/EID2/GPC3 34 GO:0050808 synapse organization 39/998 426/18722 0.000725001917808123 0.0143925285660692 APP/CDH1/NRP2/MYH10/DAG1/NRP1/DLG5/DLG1/IGF1R/ANK3/PPFIBP1/PPP1R9A/OBSL1/EFNA1/PLXNB1/PPFIA1/CDKL5/WASF2/NRCAM/CLN3/ERC1/HOMER1/EIF4G1/SEMA3F/AFG3L2/TPBG/NEDD4/CLSTN1/RYK/VCP/MAPK14/CTNNB1/CAST/DHX36/FZD5/SDF4/OPHN1/SHANK2/VPS35 39 GO:0048483 autonomic nervous system development 9/998 47/18722 0.000731060270810455 0.0144545150173956 NRP2/NRP1/NF1/TFAP2A/TP63/SEMA3F/NAV2/CTNNB1/GATA3 9 GO:0007492 endoderm development 12/998 77/18722 0.00073366145941579 0.0144545150173956 LAMB1/LAMC1/ITGAV/ITGB5/BPTF/COL4A2/MMP15/SETD2/CTNNB1/MMP14/COL5A2/DUSP5 12 GO:0030705 cytoskeleton-dependent intracellular transport 22/998 195/18722 0.000738156080826616 0.0144883943533675 APP/SYNE2/DST/CCDC186/DYNC1H1/ARHGAP21/FNBP1L/HOOK2/MYO7A/CLN3/LRPPRC/SFPQ/RAB6A/ACTN4/PURA/PCM1/SUN1/MYO1C/FLOT2/MYO6/ARMCX3/HNRNPU 22 GO:0043254 regulation of protein-containing complex assembly 39/998 427/18722 0.000758122335227822 0.0148245569746234 MET/KANK1/RASA1/CLIP1/TFRC/AKAP9/HSPA5/LMO4/DLG1/PARP1/IQGAP2/MPP7/KANK4/SCIN/ABCA1/PPP1R9A/ISL1/FERMT1/WASF2/FERMT2/EIF4G1/ICE1/CAMSAP2/TRIOBP/HSP90AA1/JAM3/VCP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/OCLN/HSPA1B/ADD3/GSK3B 39 GO:0001508 action potential 17/998 134/18722 0.000776651178438914 0.0151302082187671 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/ANK3/USP53/DMD/CLN3/SLC9A1/FMR1/P2RX4/PKP2/ATP2A2/GPD1L 17 GO:0031032 actomyosin structure organization 22/998 196/18722 0.000790701444950619 0.0153466626174245 MET/MYH10/NRP1/ITGB5/ITGB1/FRMD6/CD47/TACSTD2/PPP1R9A/OBSL1/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/EPB41L3/TGFBR1/SORBS1/TRPM7/PLEC/PHLDB2/CDC42BPB 22 GO:0060713 labyrinthine layer morphogenesis 6/998 22/18722 0.000806603034370232 0.0155973127498036 SPINT1/BMP7/SPINT2/FGFR2/FZD5/ST14 6 GO:0010452 histone H3-K36 methylation 5/998 15/18722 0.00081681551536911 0.0156212227316561 BRD4/ASH1L/SMYD2/SETD2/NSD1 5 GO:0086069 bundle of His cell to Purkinje myocyte communication 5/998 15/18722 0.00081681551536911 0.0156212227316561 DSP/DSC2/GJA5/DSG2/PKP2 5 GO:1905146 lysosomal protein catabolic process 5/998 15/18722 0.00081681551536911 0.0156212227316561 LRP2/LRP1/CLN3/VPS13A/TMEM106B 5 GO:1902305 regulation of sodium ion transmembrane transport 11/998 68/18722 0.000877033859736715 0.0167116561375379 UTRN/DLG1/FXYD3/ANK3/ATP2B4/DMD/SLC9A1/NEDD4/ACTN4/STOM/GPD1L 11 GO:0090287 regulation of cellular response to growth factor stimulus 30/998 304/18722 0.000885158321297916 0.0168051330745324 FBN2/FBN1/LRP2/PEG10/SEMA6A/CRIM1/HSPA5/GLG1/TGFBR3/ZNF451/TRIM33/ATP2B4/FOLR1/FSTL1/FERMT1/EPN2/NREP/LATS2/NEDD4/PTPN1/PPARG/PIK3CB/ZDHHC17/CDKN1C/CTNNB1/MYO1C/GATA3/EID2/GPC3/GPC1 30 GO:1903115 regulation of actin filament-based movement 8/998 39/18722 0.000890075568785904 0.0168372628428667 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/PKP2/ATP2A2 8 GO:2000736 regulation of stem cell differentiation 10/998 58/18722 0.000894712474923434 0.0168638766482861 YAP1/PRKDC/N4BP2L2/TACSTD2/DHX36/LTBP3/NFE2L2/HSPA9/HNRNPU/OCIAD1 10 GO:0072073 kidney epithelium development 17/998 136/18722 0.000919337086415366 0.0172656795977504 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/CD24/YAP1/TACSTD2/GLI3/IRX2/AHI1/FGFR2/CTNNB1/GATA3/BCL2/GPC3 17 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 12/998 79/18722 0.000927353851594844 0.0173538152658662 NRP1/P4HB/CALR/CUX1/PRKDC/OBSL1/CDKL5/FERMT2/TRIOBP/DHX36/DOCK1/NEDD9 12 GO:0120032 regulation of plasma membrane bounded cell projection assembly 21/998 186/18722 0.000954482749272567 0.0177976944069717 KANK1/NRP1/YAP1/FNBP1L/TACSTD2/PPP1R9A/ATMIN/COBL/CDKL5/WASF2/LIMK2/CLN3/KLF5/FMR1/TGFBR1/SH3YL1/RDX/NCKAP1/EPS8/MAP4/OCLN 21 GO:0009411 response to UV 18/998 149/18722 0.00098691097661889 0.01827397565157 EGFR/MME/DDB1/PARP1/OPN3/MDM2/USP47/MAP3K4/CCND1/UBE4B/FMR1/NEDD4/EIF2AK4/DHX36/BCL2/SDF4/XPC/YY1 18 GO:0015807 L-amino acid transport 11/998 69/18722 0.000994025873404691 0.01827397565157 ITGB1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC7A6/SLC1A5/SLC7A2/SLC1A3/SLC38A2/SERINC3 11 GO:0034605 cellular response to heat 11/998 69/18722 0.000994025873404691 0.01827397565157 HSPD1/TPR/RBBP7/HSP90AA1/VCP/DHX36/SLC52A3/ATP2A2/HSPA1B/GSK3B/HDAC2 11 GO:0045669 positive regulation of osteoblast differentiation 11/998 69/18722 0.000994025873404691 0.01827397565157 FBN2/BMP7/LRP5/SUCO/YAP1/IL6ST/GLI3/FERMT2/TP63/CTNNB1/ATRAID 11 GO:0043542 endothelial cell migration 28/998 279/18722 0.00100102493086701 0.0183380742598479 MET/NRP2/NRP1/DPP4/SERPINF1/ITGB1/NR2F2/NF1/AMOT/CALR/EPHB4/PLPP3/ATP2B4/FSTL1/EFNA1/TGFBR1/P2RX4/MIA3/PPARG/PIK3CB/PTPRM/PTK2/GATA3/PLK2/LGALS8/EMC10/ANXA3/NFE2L2 28 GO:0030201 heparan sulfate proteoglycan metabolic process 7/998 31/18722 0.00102021439491141 0.0185385231742704 EXTL2/HS6ST2/GLCE/CTNNB1/TCF7L2/EXT2/GPC1 7 GO:0090162 establishment of epithelial cell polarity 7/998 31/18722 0.00102021439491141 0.0185385231742704 FRMD4A/FERMT1/FAT1/FRMD4B/CYTH3/PARD3/OPHN1 7 GO:0061136 regulation of proteasomal protein catabolic process 21/998 187/18722 0.00102261916762878 0.0185385231742704 GNA12/MDM2/USP25/RNF217/HECTD1/RAD23B/UFL1/FMR1/TMTC3/BCAP31/VCP/SMARCC1/PLK2/HSPA1B/GSK3B/OPHN1/TMF1/ALAD/NFE2L2/USP14/TMEM259 21 GO:0030042 actin filament depolymerization 10/998 59/18722 0.00102671942292449 0.018548450197539 LIMA1/SCIN/SWAP70/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3/MICAL3 10 GO:0001657 ureteric bud development 13/998 91/18722 0.0010426781069096 0.0187718013661207 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/TACSTD2/GLI3/FGFR2/CTNNB1/GATA3/BCL2/GPC3 13 GO:0060491 regulation of cell projection assembly 21/998 188/18722 0.0010948939662907 0.0195889905500376 KANK1/NRP1/YAP1/FNBP1L/TACSTD2/PPP1R9A/ATMIN/COBL/CDKL5/WASF2/LIMK2/CLN3/KLF5/FMR1/TGFBR1/SH3YL1/RDX/NCKAP1/EPS8/MAP4/OCLN 21 GO:0098657 import into cell 24/998 227/18722 0.0010955727333099 0.0195889905500376 LRP2/SLC2A1/SLC6A4/SLC27A2/ITGB1/DLG1/SLC43A2/SLC39A10/SLC38A1/SLC5A3/ARL6IP5/SLC19A1/ATP2B4/FOLR1/SLC16A2/SLC12A9/SLC9A1/SLC1A5/SLC7A2/TRPV6/SLC1A3/SLC5A6/ACSL3/SLC29A1 24 GO:0021783 preganglionic parasympathetic fiber development 5/998 16/18722 0.00113626848053476 0.0202472960302797 NRP2/NRP1/TFAP2A/SEMA3F/NAV2 5 GO:0030900 forebrain development 35/998 379/18722 0.00114047447529019 0.0202531198486056 LRP2/APP/CDH1/NRP2/LAMB1/ADGRG1/SLC2A1/NRP1/NR2F2/CDK6/NF1/LRP1/PGAP1/ATP2B4/TACC2/ISL1/GLI3/ATRX/GNG12/RTN4/SETD2/TOP2B/KRAS/RYK/FGFR2/TRA2B/PCM1/CTNNB1/SUN1/SLC38A2/ALDH1A3/GSK3B/SECISBP2/OPHN1/ANXA3 35 GO:0072163 mesonephric epithelium development 13/998 92/18722 0.0011562421163928 0.0203943921948878 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/TACSTD2/GLI3/FGFR2/CTNNB1/GATA3/BCL2/GPC3 13 GO:0072164 mesonephric tubule development 13/998 92/18722 0.0011562421163928 0.0203943921948878 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/TACSTD2/GLI3/FGFR2/CTNNB1/GATA3/BCL2/GPC3 13 GO:0060688 regulation of morphogenesis of a branching structure 9/998 50/18722 0.00116498474201042 0.0204794119125804 MAGED1/BMP7/LGR4/TACSTD2/RTN4/FGFR2/CTNNB1/BTBD7/MAP3K13 9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 10/998 60/18722 0.00117424141354679 0.0205728671816369 MBNL3/DDX17/MBNL2/RBM25/RBM5/FMR1/TRA2B/RBFOX2/HNRNPU/SRSF2 10 GO:0008544 epidermis development 31/998 324/18722 0.00121479461784078 0.0212121829422966 EGFR/DSP/SVEP1/LGR5/LAMA5/STS/NCOA3/LGR4/EXPH5/YAP1/OPN3/MCOLN3/FERMT1/MYO7A/TP63/ESRP1/TRIOBP/IRF6/ERRFI1/FZD6/FGFR2/GRHL1/CTNNB1/BCL2/ST14/SGPP1/ATP2A2/PLEC/FLOT2/MYO6/HDAC2 31 GO:0014044 Schwann cell development 7/998 32/18722 0.00124653738575617 0.0215502373875263 ITGB4/DAG1/NF1/DICER1/PARD3/ADGRG6/PLEC 7 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 7/998 32/18722 0.00124653738575617 0.0215502373875263 BRD4/CTNNB1/TCERG1/NELFCD/ELL/HEXIM1/HNRNPU 7 GO:0051497 negative regulation of stress fiber assembly 7/998 32/18722 0.00124653738575617 0.0215502373875263 MET/TACSTD2/PPP1R9A/PPFIA1/WASF2/TJP1/PHLDB2 7 GO:0051701 biological process involved in interaction with host 22/998 203/18722 0.00125759094946076 0.0216695787034146 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/DDB1/P4HB/CD55/ANO6/SLC52A1/BSG/SLC1A5/UVRAG/SLC20A2/WWP1/HSPA1B/SLC52A2 22 GO:0007568 aging 32/998 339/18722 0.00127613583521064 0.0219167934066933 APP/MME/ATP2B1/DAG1/SERPINF1/RPN2/CDK6/LRP1/CALR/FOXO4/PRKDC/CTSV/CANX/TFCP2L1/PPP1R9A/DNMT3A/COL4A2/TP63/PAWR/PLA2R1/SEC63/KRAS/MAPK14/BCL2/PLK2/ASS1/PDCD4/PRDM2/CTNNA1/LMNA/NFE2L2/YPEL3 32 GO:0001892 embryonic placenta development 12/998 82/18722 0.00129634165684901 0.0221248238604916 SPINT1/BMP7/SPINT2/NR2F2/HECTD1/BPTF/BIRC6/SETD2/FGFR2/FZD5/ST14/PHLDA2 12 GO:0042996 regulation of Golgi to plasma membrane protein transport 4/998 10/18722 0.0013009616788299 0.0221248238604916 CLN3/GOPC/ACSL3/LYPLA1 4 GO:0048755 branching morphogenesis of a nerve 4/998 10/18722 0.0013009616788299 0.0221248238604916 RERE/RTN4/FGFR2/MAP3K13 4 GO:0048511 rhythmic process 29/998 298/18722 0.00132728245217483 0.0222935341119081 EGFR/MAGED1/SLC6A4/ADRB1/SERPINF1/HSPA5/DDB1/LGR4/CLDN4/ADAMTS1/PRKDC/OPN3/GFPT1/KDM5B/ZFHX3/HUWE1/USP9X/SFPQ/SIAH2/MYCBP2/PPARG/PLEKHA1/BHLHE41/NR2F6/GPR157/ASS1/GSK3B/HDAC2/HNRNPU 29 GO:0021801 cerebral cortex radial glia-guided migration 6/998 24/18722 0.00132796190553599 0.0222935341119081 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:0022030 telencephalon glial cell migration 6/998 24/18722 0.00132796190553599 0.0222935341119081 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:1903077 negative regulation of protein localization to plasma membrane 6/998 24/18722 0.00132796190553599 0.0222935341119081 CLTC/HECTD1/PPFIA1/TMEM59/GOPC/LYPLA1 6 GO:0043954 cellular component maintenance 10/998 61/18722 0.00133860836635171 0.022400238079238 DLG1/IGF1R/FERMT2/ERC1/HOMER1/TJP1/KIFC3/SDF4/OPHN1/VPS35 10 GO:0032231 regulation of actin filament bundle assembly 14/998 105/18722 0.00135338171811812 0.0225750988827306 MET/NRP1/CD47/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/SWAP70/RDX/PHLDB2 14 GO:0006898 receptor-mediated endocytosis 25/998 244/18722 0.00136331871501881 0.0226684299716982 LRP2/CTSL/ITGAV/TFRC/ITGB1/LRPAP1/AAK1/LRP1/CLTC/FNBP1L/CANX/FOLR1/CLN3/CD2AP/AHI1/EZR/FMR1/NEDD4/PLA2R1/PIK3CB/RAB31/AP2A2/ATXN2/OPHN1/ANXA2 25 GO:0006022 aminoglycan metabolic process 16/998 129/18722 0.001394857784461 0.0231192142624473 ITIH5/CLTC/CHPF/GCNT2/HEXB/FUCA1/HS6ST2/B3GNT3/GLCE/HEXA/B3GNT2/GUSB/EXT2/GNS/B4GAT1/GLB1 16 GO:0031331 positive regulation of cellular catabolic process 38/998 427/18722 0.00141464804907095 0.0233730299499982 LRP2/APP/KCNQ1OT1/LRP1/LIN28B/RNF128/PTTG1IP/MDM2/RNF217/HECTD1/PUM1/UFL1/DCP2/TMEM59/EZR/FMR1/TMTC3/PTPN1/HSP90AA1/PIK3CB/BCAP31/UVRAG/VCP/VGLL4/DHX36/AGO2/NRDC/SH3D19/RDX/PTK2/PLK2/TNRC6A/HSPA1B/GSK3B/ATF6/VPS35/NFE2L2/TMEM259 38 GO:0030038 contractile actin filament bundle assembly 14/998 106/18722 0.00148457676977374 0.0242841885406149 MET/NRP1/ITGB5/CD47/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/SORBS1/PHLDB2 14 GO:0043149 stress fiber assembly 14/998 106/18722 0.00148457676977374 0.0242841885406149 MET/NRP1/ITGB5/CD47/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/SORBS1/PHLDB2 14 GO:0090263 positive regulation of canonical Wnt signaling pathway 14/998 106/18722 0.00148457676977374 0.0242841885406149 EGFR/LGR5/WLS/KANK1/LGR4/TBL1X/YAP1/USP47/VCP/FGFR2/USP34/TNKS2/UBR5/GPC3 14 GO:0072006 nephron development 17/998 142/18722 0.00148840075330334 0.0242841885406149 MAGED1/LAMA5/BMP7/ENPEP/LGR4/PBX1/DLG1/CD24/YAP1/TACSTD2/GLI3/IRX2/AHI1/CTNNB1/GATA3/BCL2/GPC3 17 GO:0048048 embryonic eye morphogenesis 7/998 33/18722 0.00151031912769707 0.024362073425099 FBN2/FBN1/EFEMP1/BMP7/TFAP2A/FZD5/ALDH1A3 7 GO:1900181 negative regulation of protein localization to nucleus 7/998 33/18722 0.00151031912769707 0.024362073425099 MAGED1/FERMT1/LATS2/TRIM29/GSK3B/OTUD7B/CTNNA1 7 GO:0046942 carboxylic acid transport 27/998 273/18722 0.00151316529990185 0.024362073425099 LRP2/SLC26A2/ITGB1/GJA1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC16A12/SLC19A1/SLC13A3/SLC16A4/FOLR1/SLC7A6/SLC16A1/SLC16A2/CLN3/SLC1A5/SLC7A2/SLC35D1/SLC1A3/PLA2R1/SLC5A6/P2RX4/SLC38A2/SLC17A5/SERINC3 27 GO:0010721 negative regulation of cell development 20/998 180/18722 0.00151650524098011 0.024362073425099 FBN1/SEMA6A/SEMA6D/KANK1/FBLN1/NRP1/BMP7/NF1/TACSTD2/PRTG/RTN4/SEMA3F/DICER1/ACTN4/RYK/PCM1/CTNNB1/SEMA4B/GSK3B/CTNNA1 20 GO:0043409 negative regulation of MAPK cascade 20/998 180/18722 0.00151650524098011 0.024362073425099 SEMA6A/DAG1/FBLN1/BMP7/DLG1/NF1/IGF1R/EIF3A/ASH1L/EFNA1/MARVELD3/DUSP9/EZR/PTPN1/PPARG/PIK3CB/ERRFI1/PDCD4/DUSP5/PEBP1 20 GO:0007565 female pregnancy 21/998 193/18722 0.0015256720794847 0.0244322974313566 ITGB4/SLC2A1/FBLN1/STS/GJA1/NR2F2/CLDN4/SLC38A1/PRLR/CALR/MAGED2/SLC19A1/CTSV/ASH1L/BSG/KRAS/SLC38A2/AGO2/DDR1/BCL2/STC2 21 GO:0042339 keratan sulfate metabolic process 5/998 17/18722 0.00153959506893628 0.0244322974313566 B3GNT3/B3GNT2/GNS/B4GAT1/GLB1 5 GO:0048532 anatomical structure arrangement 5/998 17/18722 0.00153959506893628 0.0244322974313566 NRP2/NRP1/HSPA5/TFAP2A/SEMA3F 5 GO:0060977 coronary vasculature morphogenesis 5/998 17/18722 0.00153959506893628 0.0244322974313566 LRP2/NRP1/TGFBR3/TGFBR1/SETD2 5 GO:0031103 axon regeneration 9/998 52/18722 0.00155533432109368 0.0245329319952571 DAG1/LRP1/MTR/FOLR1/ISL1/NREP/JAM3/BCL2/CTNNA1 9 GO:0032206 positive regulation of telomere maintenance 9/998 52/18722 0.00155533432109368 0.0245329319952571 RAD50/ATRX/MAP3K4/PKIB/CTNNB1/DHX36/TNKS2/PPP1R10/HNRNPA2B1 9 GO:0072089 stem cell proliferation 11/998 73/18722 0.0015982052169083 0.0250577460584932 FBLN1/RNF43/GJA1/YAP1/ZNRF3/N4BP2L2/FERMT1/FERMT2/ABCB1/LTBP3/HNRNPU 11 GO:0086003 cardiac muscle cell contraction 11/998 73/18722 0.0015982052169083 0.0250577460584932 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/SLC9A1/PKP2/ATP2A2/GPD1L 11 GO:0008361 regulation of cell size 20/998 181/18722 0.0016217515131323 0.0253445555089008 SEMA6A/SEMA6D/NRP1/GOLGA4/ANO6/LRP1/KCNN4/VAV3/CDKL5/SLC12A9/NRCAM/CLN3/MACF1/RTN4/SEMA3F/RYK/SEMA4B/RDX/GSK3B/MAP3K13 20 GO:0031532 actin cytoskeleton reorganization 14/998 107/18722 0.00162620687521198 0.0253445555089008 NRK/NRP1/THSD7A/IQGAP2/GAB1/CD2AP/TJP1/S1PR2/EZR/PTPN1/NEDD9/EPS8/PLEC/CDC42BPB 14 GO:0000723 telomere maintenance 16/998 131/18722 0.00164121693744386 0.0255023619952214 PARP1/PRKDC/RAD50/ATRX/MAP3K4/DCP2/PKIB/HSP90AA1/RIF1/CTNNB1/DHX36/TNKS2/YLPM1/PPP1R10/HNRNPU/HNRNPA2B1 16 GO:0010560 positive regulation of glycoprotein biosynthetic process 6/998 25/18722 0.00166939943533954 0.0255599250789084 PAWR/NCSTN/CTNNB1/TCF7L2/GOLGA2/ARFGEF1 6 GO:0015012 heparan sulfate proteoglycan biosynthetic process 6/998 25/18722 0.00166939943533954 0.0255599250789084 EXTL2/HS6ST2/GLCE/CTNNB1/TCF7L2/EXT2 6 GO:0032469 endoplasmic reticulum calcium ion homeostasis 6/998 25/18722 0.00166939943533954 0.0255599250789084 APP/TGM2/CCDC47/BCAP31/BCL2/ATP2A2 6 GO:0061436 establishment of skin barrier 6/998 25/18722 0.00166939943533954 0.0255599250789084 MET/CLDN4/TP63/LSR/GRHL1/PLEC 6 GO:1903959 regulation of anion transmembrane transport 6/998 25/18722 0.00166939943533954 0.0255599250789084 TCAF1/ITGB1/SLC43A2/ARL6IP5/GOPC/ABCB1 6 GO:0008406 gonad development 23/998 221/18722 0.00169528596017606 0.0258049212771989 LRP2/ADGRG1/HSPA5/NR2F2/ADAMTS1/RHOBTB3/IDH1/CTSV/ZFX/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/TGFBR1/ARID5B/PLEKHA1/MMP14/GATA3/BCL2/TMF1/CTNNA1 23 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 23/998 221/18722 0.00169528596017606 0.0258049212771989 GNA12/MDM2/USP25/RNF217/HECTD1/EFNA1/RAD23B/UFL1/FMR1/TMTC3/BCAP31/VCP/PTK2/SMARCC1/PLK2/HSPA1B/GSK3B/OPHN1/TMF1/ALAD/NFE2L2/USP14/TMEM259 23 GO:0001823 mesonephros development 13/998 96/18722 0.00171880109966278 0.0260111899748968 MAGED1/LAMA5/BMP7/LGR4/PBX1/DLG1/TACSTD2/GLI3/FGFR2/CTNNB1/GATA3/BCL2/GPC3 13 GO:0034620 cellular response to unfolded protein 13/998 96/18722 0.00171880109966278 0.0260111899748968 HSPA5/HSPD1/ERLEC1/CREB3L2/CCND1/MBTPS1/UFL1/PTPN1/VCP/HSPA1B/ATF6/NFE2L2/HSPA9 13 GO:0072175 epithelial tube formation 16/998 132/18722 0.00177747740056112 0.0267524345819905 LRP2/SPINT1/BMP7/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/IRX2/SETD2/FZD6/FGFR2/CTNNB1/GATA3/ST14 16 GO:0007566 embryo implantation 9/998 53/18722 0.00178645406618267 0.0267524345819905 ITGB4/FBLN1/GJA1/PRLR/CALR/BSG/AGO2/DDR1/STC2 9 GO:0003151 outflow tract morphogenesis 11/998 74/18722 0.00178870144691508 0.0267524345819905 LRP2/NRP2/NRP1/BMP7/GJA5/TGFBR3/FOLR1/ISL1/FGFR2/CTNNB1/NIPBL 11 GO:0071375 cellular response to peptide hormone stimulus 28/998 290/18722 0.00178925496500759 0.0267524345819905 FBN1/ATP2B1/KANK1/IGF1R/PARP1/FOXO4/PRKDC/GAB1/MDM2/DENND4C/SRSF5/SLC9A1/LEPROT/PRKCI/SORBS1/PTPN1/PPARG/AHCYL1/ERRFI1/RAB31/USO1/MYO1C/PTK2/SMARCC1/ASS1/PTPRA/GSK3B/NFE2L2 28 GO:0048593 camera-type eye morphogenesis 15/998 120/18722 0.00179515732512863 0.0267524345819905 TENM3/BMP7/NF1/LRP5/TFAP2A/OBSL1/GLI3/FAT1/AHI1/PTPRM/CTNNB1/FZD5/MAN2A1/ALDH1A3/YY1 15 GO:0015931 nucleobase-containing compound transport 23/998 222/18722 0.00179852605598136 0.0267524345819905 GJA1/SLC35B4/IGF2BP3/NCBP3/CD47/SLC19A1/TPR/SLC25A36/LRPPRC/FMR1/SLC35D1/SETD2/MYO1C/RANBP17/RANBP2/SLC29A3/ATXN2/QKI/AGFG1/PABPN1/SLC29A1/HNRNPA2B1/TOMM20 23 GO:0030178 negative regulation of Wnt signaling pathway 19/998 170/18722 0.00183548024764591 0.0272245521959071 RNF43/CTNND1/TLE4/LRP1/ZNRF3/ISL1/FERMT1/GLI3/SIAH2/TPBG/LATS2/FZD6/MAPK14/RBMS3/VGLL4/TCF7L2/TLE1/GSK3B/GPC3 19 GO:0048738 cardiac muscle tissue development 24/998 236/18722 0.00186064706043279 0.0275196552479308 LRP2/DSP/BMP7/ITGB1/GJA1/GJA5/DSG2/TGFBR3/CALR/YAP1/ISL1/OBSL1/SLC9A1/TGFBR1/MSX2/MAPK14/FGFR2/VGLL4/PKP2/PPP1R13L/PLEC/YY1/LMNA/HNRNPU 24 GO:0030837 negative regulation of actin filament polymerization 10/998 64/18722 0.00194704458713268 0.0283247311781889 KANK1/KANK4/SCIN/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 10 GO:0001838 embryonic epithelial tube formation 15/998 121/18722 0.00195068300319088 0.0283247311781889 LRP2/SPINT1/BMP7/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/IRX2/SETD2/FZD6/CTNNB1/GATA3/ST14 15 GO:0003206 cardiac chamber morphogenesis 15/998 121/18722 0.00195068300319088 0.0283247311781889 LRP2/DSP/NRP2/NRP1/BMP7/ADAMTS1/TGFBR3/MDM2/ISL1/TGFBR1/FGFR2/PKP2/ADGRG6/PPP1R13L/GATA3 15 GO:0045931 positive regulation of mitotic cell cycle 15/998 121/18722 0.00195068300319088 0.0283247311781889 EGFR/APP/BRD4/PBX1/ADAMTS1/MDM2/CCND1/EIF4G1/ANKRD17/PKN2/RDX/ANAPC5/USP22/MEIS2/PPP1R10 15 GO:0033327 Leydig cell differentiation 4/998 11/18722 0.00195848074225746 0.0283247311781889 SF1/CCND1/PLEKHA1/TMF1 4 GO:0043589 skin morphogenesis 4/998 11/18722 0.00195848074225746 0.0283247311781889 ITGA6/ITGB4/TP63/ERRFI1 4 GO:0051657 maintenance of organelle location 4/998 11/18722 0.00195848074225746 0.0283247311781889 AKAP9/ARHGAP21/UVRAG/GPSM2 4 GO:0098935 dendritic transport 4/998 11/18722 0.00195848074225746 0.0283247311781889 SFPQ/PURA/FLOT2/HNRNPU 4 GO:0048864 stem cell development 12/998 86/18722 0.0019695754121417 0.0283545870724105 NRP2/SEMA6A/SEMA6D/NRP1/MSI2/LAMA5/BMP7/FOLR1/ISL1/SEMA3F/SETD2/SEMA4B 12 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 30/998 320/18722 0.00197683771200104 0.0283545870724105 MBNL3/RBM39/SON/SF1/SRSF5/DDX17/PNN/SRRM2/MBNL2/RBM25/SFPQ/RBM5/FMR1/PAXBP1/TRA2B/SF3B1/DDX1/SNRNP200/RBFOX2/PRPF8/RBM6/QKI/PRPF4B/PRPF40A/SRSF4/TIA1/HNRNPU/LUC7L3/SRSF2/HNRNPA2B1 30 GO:0000398 mRNA splicing, via spliceosome 30/998 320/18722 0.00197683771200104 0.0283545870724105 MBNL3/RBM39/SON/SF1/SRSF5/DDX17/PNN/SRRM2/MBNL2/RBM25/SFPQ/RBM5/FMR1/PAXBP1/TRA2B/SF3B1/DDX1/SNRNP200/RBFOX2/PRPF8/RBM6/QKI/PRPF4B/PRPF40A/SRSF4/TIA1/HNRNPU/LUC7L3/SRSF2/HNRNPA2B1 30 GO:0048486 parasympathetic nervous system development 5/998 18/18722 0.00203902240870166 0.0291611597278807 NRP2/NRP1/TFAP2A/SEMA3F/NAV2 5 GO:0030834 regulation of actin filament depolymerization 9/998 54/18722 0.00204424142126113 0.0291611597278807 LIMA1/SCIN/SWAP70/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 9 GO:0048843 negative regulation of axon extension involved in axon guidance 6/998 26/18722 0.00207355193742356 0.0294185181121967 SEMA6A/SEMA6D/NRP1/SEMA3F/RYK/SEMA4B 6 GO:1904376 negative regulation of protein localization to cell periphery 6/998 26/18722 0.00207355193742356 0.0294185181121967 CLTC/HECTD1/PPFIA1/TMEM59/GOPC/LYPLA1 6 GO:0051896 regulation of protein kinase B signaling 20/998 185/18722 0.00210701108232019 0.0298122082948339 EGFR/LRP2/MET/DAG1/ITGB1/DLG1/IGF1R/GCNT2/FERMT2/RTN4/TPBG/TGFBR1/P2RX4/HSP90AA1/PIK3CB/PLEKHA1/TCF7L2/PTK2/GATA3/ARFGEF1 20 GO:0061387 regulation of extent of cell growth 14/998 110/18722 0.00212012498832412 0.0299166826055141 SEMA6A/SEMA6D/NRP1/GOLGA4/LRP1/CDKL5/NRCAM/MACF1/RTN4/SEMA3F/RYK/SEMA4B/GSK3B/MAP3K13 14 GO:0016485 protein processing 23/998 225/18722 0.00214102232031948 0.0299813200189838 MME/CTSL/ASPH/PERP/ENPEP/GLG1/PARP1/PISD/MDM2/LPCAT3/GLI3/CLN3/CPD/DHCR24/PRSS12/TMEM59/NCSTN/AFG3L2/CAST/MMP14/PCSK7/SPPL3/YME1L1 23 GO:0050878 regulation of body fluid levels 34/998 379/18722 0.002154702662284 0.0299813200189838 F5/EGFR/MET/FBLN1/LMAN1/GJA1/CLDN4/GJA5/ANO6/PRLR/GNA12/IL6ST/KCNN4/VAV3/ATP6V1B1/CCND1/TP63/HPS5/LSR/CD59/PIK3CB/CDO1/FZD6/MAPK14/GRHL1/ANXA5/DDR1/EXT2/PLEC/AK3/SLC29A1/NFE2L2/ANXA2/GNAS 34 GO:0015695 organic cation transport 7/998 35/18722 0.00216669110343683 0.0299813200189838 ATP13A3/SLC19A3/SLC44A1/SLC44A2/SLC22A5/SLC38A2/SLC29A1 7 GO:0032232 negative regulation of actin filament bundle assembly 7/998 35/18722 0.00216669110343683 0.0299813200189838 MET/TACSTD2/PPP1R9A/PPFIA1/WASF2/TJP1/PHLDB2 7 GO:0034331 cell junction maintenance 7/998 35/18722 0.00216669110343683 0.0299813200189838 DLG1/FERMT2/ERC1/TJP1/KIFC3/SDF4/OPHN1 7 GO:0060236 regulation of mitotic spindle organization 7/998 35/18722 0.00216669110343683 0.0299813200189838 CLTC/DYNC1H1/TPR/GNAI1/HSPA1B/GPSM2/HNRNPU 7 GO:1905898 positive regulation of response to endoplasmic reticulum stress 7/998 35/18722 0.00216669110343683 0.0299813200189838 PTPN1/BCAP31/SERINC3/ATF6/PMAIP1/NFE2L2/TMEM259 7 GO:0043010 camera-type eye development 30/998 322/18722 0.00217289818521516 0.0299813200189838 FBN2/FBN1/TENM3/EFEMP1/ATP2B1/NRP1/BMP7/SERPINF1/DLG1/NF1/LRP5/ATP2B4/TFAP2A/OBSL1/GLI3/KDM5B/LIMK2/FAT1/AHI1/TGFBR1/CRYBG3/PTPRM/CTNNB1/FZD5/MAN2A1/PPP1R13L/GATA3/ALDH1A3/HDAC2/YY1 30 GO:0048041 focal adhesion assembly 12/998 87/18722 0.00217638772020587 0.0299813200189838 NRP1/LRP1/SLK/SLC9A1/FERMT2/MACF1/SORBS1/MMP14/PTK2/BCL2/PTPRA/PHLDB2 12 GO:0035148 tube formation 17/998 148/18722 0.00232975495017427 0.0318566975953654 LRP2/SPINT1/BMP7/SPINT2/LMO4/TGM2/DVL3/FOLR1/HECTD1/COBL/IRX2/SETD2/FZD6/FGFR2/CTNNB1/GATA3/ST14 17 GO:0051384 response to glucocorticoid 17/998 148/18722 0.00232975495017427 0.0318566975953654 EGFR/AGL/ATP2B1/SERPINF1/CTSV/HSPD1/ISL1/CCND1/KRAS/CDO1/ERRFI1/BCL2/ASS1/ALAD/ANXA3/GLB1/HNRNPU 17 GO:0003229 ventricular cardiac muscle tissue development 9/998 55/18722 0.00233082905217958 0.0318566975953654 LRP2/DSP/DSG2/TGFBR3/ISL1/TGFBR1/FGFR2/PKP2/PPP1R13L 9 GO:0050678 regulation of epithelial cell proliferation 34/998 381/18722 0.0023471005346561 0.0319953313092416 EGFR/NRP2/LAMB1/LAMC1/MAGED1/NRP1/SERPINF1/GJA1/NR2F2/DLG1/CDK6/NF1/TGFBR3/YAP1/PRKDC/ISL1/B4GALT1/KDM5B/CCND1/TP63/MARVELD3/RTN4/TGFBR1/SUZ12/PPARG/ERRFI1/PTPRM/FGFR2/CDKN1C/CTNNB1/TCF7L2/GATA3/GPC3/EMC10 34 GO:0000375 RNA splicing, via transesterification reactions 30/998 324/18722 0.00238542956133499 0.032197244814572 MBNL3/RBM39/SON/SF1/SRSF5/DDX17/PNN/SRRM2/MBNL2/RBM25/SFPQ/RBM5/FMR1/PAXBP1/TRA2B/SF3B1/DDX1/SNRNP200/RBFOX2/PRPF8/RBM6/QKI/PRPF4B/PRPF40A/SRSF4/TIA1/HNRNPU/LUC7L3/SRSF2/HNRNPA2B1 30 GO:0008064 regulation of actin polymerization or depolymerization 20/998 187/18722 0.00239236701343531 0.032197244814572 KANK1/RASA1/DLG1/IQGAP2/LIMA1/KANK4/SCIN/PPP1R9A/WASF2/SWAP70/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 20 GO:0033044 regulation of chromosome organization 20/998 187/18722 0.00239236701343531 0.032197244814572 DNMT1/PARP1/RAD50/ATRX/MAP3K4/TPR/SFPQ/DCP2/PKIB/MPHOSPH8/RAD21/CTNNB1/DHX36/TNKS2/WAPL/ANAPC5/YLPM1/PPP1R10/HNRNPU/HNRNPA2B1 20 GO:0051271 negative regulation of cellular component movement 33/998 367/18722 0.0023930133066103 0.032197244814572 CDH1/TCAF1/ADGRG1/SEMA6D/DAG1/KANK1/FBLN1/DPP4/SERPINF1/DLG5/GJA1/SPINT2/NR2F2/NF1/LRP1/TGFBR3/CALR/GNA12/ATP2B4/TACSTD2/CCDC125/MARVELD3/STK26/S1PR2/MIA3/PPARG/PTPRM/GATA3/BCL2/SRGAP1/PHLDB2/CTNNA1/NFE2L2 33 GO:0007584 response to nutrient 19/998 174/18722 0.00239838649933585 0.032197244814572 EGFR/AGL/ATP2B1/BMP7/SLC6A4/MDM2/FOLR1/ABCA1/DNMT3A/SLC16A1/CCND1/PPARG/TRIM24/ASS1/STC2/ACSL3/TTPA/ALAD/SRSF2 19 GO:0045137 development of primary sexual characteristics 23/998 227/18722 0.00239891366268311 0.032197244814572 LRP2/ADGRG1/HSPA5/NR2F2/ADAMTS1/RHOBTB3/IDH1/CTSV/ZFX/TFAP2C/SF1/ATRX/TLR3/CCND1/PRDX4/TGFBR1/ARID5B/PLEKHA1/MMP14/GATA3/BCL2/TMF1/CTNNA1 23 GO:0051893 regulation of focal adhesion assembly 10/998 66/18722 0.00246414893105738 0.0328652049874427 NRP1/LRP1/SLK/SLC9A1/FERMT2/MACF1/MMP14/PTK2/PTPRA/PHLDB2 10 GO:0090109 regulation of cell-substrate junction assembly 10/998 66/18722 0.00246414893105738 0.0328652049874427 NRP1/LRP1/SLK/SLC9A1/FERMT2/MACF1/MMP14/PTK2/PTPRA/PHLDB2 10 GO:0000380 alternative mRNA splicing, via spliceosome 11/998 77/18722 0.00247386047884792 0.0328652049874427 MBNL3/DDX17/MBNL2/RBM25/SFPQ/RBM5/FMR1/TRA2B/RBFOX2/HNRNPU/SRSF2 11 GO:0055117 regulation of cardiac muscle contraction 11/998 77/18722 0.00247386047884792 0.0328652049874427 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/DMD/SLC9A1/P2RX4/PKP2/ATP2A2 11 GO:0030832 regulation of actin filament length 20/998 188/18722 0.00254682809047634 0.0335009523689347 KANK1/RASA1/DLG1/IQGAP2/LIMA1/KANK4/SCIN/PPP1R9A/WASF2/SWAP70/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 20 GO:0010586 miRNA metabolic process 6/998 27/18722 0.00254738136189755 0.0335009523689347 KCNQ1OT1/LIN28B/SND1/DDX17/DICER1/AGO2 6 GO:0033561 regulation of water loss via skin 6/998 27/18722 0.00254738136189755 0.0335009523689347 MET/CLDN4/TP63/LSR/GRHL1/PLEC 6 GO:0033688 regulation of osteoblast proliferation 6/998 27/18722 0.00254738136189755 0.0335009523689347 ITGAV/LRP5/PLXNB1/FGFR2/BCL2/ATRAID 6 GO:0055123 digestive system development 16/998 137/18722 0.00260907224935373 0.034139225554585 EGFR/WLS/LGR4/YAP1/IL6ST/GLI3/COBL/KLF5/TP63/AHI1/FGFR2/CTNNB1/BCL2/YIPF6/ASS1/NIPBL 16 GO:0090090 negative regulation of canonical Wnt signaling pathway 16/998 137/18722 0.00260907224935373 0.034139225554585 CTNND1/TLE4/ZNRF3/ISL1/FERMT1/GLI3/SIAH2/TPBG/LATS2/FZD6/MAPK14/RBMS3/TCF7L2/TLE1/GSK3B/GPC3 16 GO:0051235 maintenance of location 30/998 326/18722 0.00261553154986286 0.034139225554585 FBN2/FBN1/HSP90B1/ITGAV/AKAP9/HSPA5/GJA1/MEST/ANK3/CALR/ARHGAP21/SCIN/HEXB/MCOLN3/DMD/ABCA1/CDS1/VPS13A/PPARG/UVRAG/GM2A/SUN1/GOPC/GAA/GPSM2/HILPDA/SLC30A7/SQLE/HNRNPU/KDELR1 30 GO:1900407 regulation of cellular response to oxidative stress 12/998 89/18722 0.00264329813285425 0.0342085724882941 MET/BMP7/P4HB/PARP1/FUT8/SFPQ/STK26/PAWR/CTNNB1/OXR1/NFE2L2/PAGE4 12 GO:0030050 vesicle transport along actin filament 5/998 19/18722 0.00264705291807523 0.0342085724882941 FNBP1L/MYO7A/ACTN4/MYO1C/MYO6 5 GO:0035461 vitamin transmembrane transport 5/998 19/18722 0.00264705291807523 0.0342085724882941 LRP2/SLC19A1/SLC19A3/FOLR1/SLC5A6 5 GO:0045947 negative regulation of translational initiation 5/998 19/18722 0.00264705291807523 0.0342085724882941 EIF2AK1/TPR/FMR1/EIF2AK4/AGO2 5 GO:0061008 hepaticobiliary system development 17/998 150/18722 0.00268621060868709 0.0345842389861293 EGFR/MET/NF1/TGFBR3/GLI3/SRSF5/COBL/CCND1/LSR/SEC63/KRAS/ARID5B/MAN2A1/ASS1/NIPBL/PRKCSH/KRT18 17 GO:2000027 regulation of animal organ morphogenesis 15/998 125/18722 0.0026893700494864 0.0345842389861293 MAGED1/BMP7/LGR4/ZNRF3/DVL3/TACSTD2/AHI1/RYK/FZD6/CTNNB1/SP6/GATA3/DAAM1/BTBD7/GPC3 15 GO:0048701 embryonic cranial skeleton morphogenesis 8/998 46/18722 0.00271549630000599 0.0347490347606159 TFAP2A/GLI3/TGFBR1/SETD2/SLC39A1/FGFR2/MMP14/NIPBL 8 GO:0050919 negative chemotaxis 8/998 46/18722 0.00271549630000599 0.0347490347606159 NRP2/SEMA6A/SEMA6D/ITGAV/DPP4/SEMA3F/RYK/SEMA4B 8 GO:0009880 embryonic pattern specification 10/998 67/18722 0.00276107475238708 0.0352458955555329 NRP2/NRP1/BMP7/PGAP1/COBL/SEMA3F/FGFR2/CTNNB1/FZD5/MEIS2 10 GO:2001233 regulation of apoptotic signaling pathway 32/998 356/18722 0.00277535030038767 0.035341716873961 ITGA6/MAGED1/NRP1/ITGAV/P4HB/IFI6/PDIA3/PARP1/YAP1/PTTG1IP/MDM2/USP47/SIAH1/TP63/SFPQ/SIAH2/ERP29/BCLAF1/BIRC6/TGFBR1/PTPN1/BCAP31/CTNNB1/TCF7L2/BCL2/SERINC3/HSPA1B/GSK3B/PMAIP1/CTNNA1/LMNA/NFE2L2 32 GO:0009886 post-embryonic animal morphogenesis 4/998 12/18722 0.00281454079860269 0.035494486737934 FBN1/EFEMP1/ATRX/MYO7A 4 GO:0021559 trigeminal nerve development 4/998 12/18722 0.00281454079860269 0.035494486737934 NRP1/TFAP2A/ISL1/SEMA3F 4 GO:0072182 regulation of nephron tubule epithelial cell differentiation 4/998 12/18722 0.00281454079860269 0.035494486737934 CD24/YAP1/CTNNB1/GATA3 4 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 4/998 12/18722 0.00281454079860269 0.035494486737934 NRP1/PLXNB1/SEMA3F/PLXNA1 4 GO:0032869 cellular response to insulin stimulus 21/998 203/18722 0.00283041119047701 0.0356086188565795 ATP2B1/KANK1/IGF1R/PARP1/FOXO4/PRKDC/GAB1/DENND4C/SRSF5/SLC9A1/PRKCI/SORBS1/PTPN1/PPARG/ERRFI1/RAB31/USO1/MYO1C/SMARCC1/PTPRA/GSK3B 21 GO:0034644 cellular response to UV 12/998 90/18722 0.0029055614828969 0.0363729429666321 MME/DDB1/PARP1/OPN3/MDM2/USP47/FMR1/NEDD4/EIF2AK4/DHX36/XPC/YY1 12 GO:0098739 import across plasma membrane 19/998 177/18722 0.00291003245204089 0.0363729429666321 LRP2/SLC2A1/ITGB1/DLG1/SLC43A2/SLC39A10/SLC5A3/ARL6IP5/SLC19A1/ATP2B4/FOLR1/SLC16A2/SLC12A9/SLC9A1/SLC1A5/SLC7A2/TRPV6/SLC1A3/SLC5A6 19 GO:0050680 negative regulation of epithelial cell proliferation 18/998 164/18722 0.0029120647692113 0.0363729429666321 MAGED1/SERPINF1/GJA1/NR2F2/DLG1/CDK6/NF1/TGFBR3/ISL1/MARVELD3/TGFBR1/SUZ12/PPARG/PTPRM/FGFR2/CDKN1C/GATA3/GPC3 18 GO:0008154 actin polymerization or depolymerization 22/998 217/18722 0.00292449938197658 0.0364410770245817 KANK1/RASA1/DLG1/IQGAP2/LIMA1/KANK4/SCIN/PPP1R9A/COBL/WASF2/SWAP70/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/MICAL3 22 GO:0021987 cerebral cortex development 14/998 114/18722 0.00296566529087591 0.0368660440087218 LAMB1/ADGRG1/SLC2A1/NF1/LRP1/TACC2/GLI3/GNG12/RTN4/TRA2B/CTNNB1/SUN1/SLC38A2/GSK3B 14 GO:0006611 protein export from nucleus 9/998 57/18722 0.00299933062277555 0.0370453628844704 CALR/PTPN14/MDM2/TPR/AHCYL1/RANBP17/TCF7L2/GSK3B/HSPA9 9 GO:0033619 membrane protein proteolysis 9/998 57/18722 0.00299933062277555 0.0370453628844704 DAG1/SPPL2A/MBTPS1/NCSTN/AFG3L2/NRDC/SH3D19/SPPL2B/SPPL3 9 GO:1901888 regulation of cell junction assembly 21/998 204/18722 0.00300137684354165 0.0370453628844704 APP/NRP1/DLG5/GJA1/LRP1/SLK/PPP1R9A/SLC9A1/FERMT2/MACF1/TJP1/EIF4G1/TPBG/CLSTN1/FZD5/MYO1C/MMP14/PTK2/PTPRA/PHLDB2/VPS35 21 GO:0048846 axon extension involved in axon guidance 7/998 37/18722 0.00302386809291393 0.0371473301484791 NRP2/SEMA6A/SEMA6D/NRP1/SEMA3F/RYK/SEMA4B 7 GO:1902284 neuron projection extension involved in neuron projection guidance 7/998 37/18722 0.00302386809291393 0.0371473301484791 NRP2/SEMA6A/SEMA6D/NRP1/SEMA3F/RYK/SEMA4B 7 GO:1903020 positive regulation of glycoprotein metabolic process 6/998 28/18722 0.00309804260369653 0.0379692028964778 PAWR/NCSTN/CTNNB1/TCF7L2/GOLGA2/ARFGEF1 6 GO:0048565 digestive tract development 15/998 127/18722 0.00313744925606628 0.0383621137375224 EGFR/LGR4/YAP1/IL6ST/GLI3/COBL/KLF5/TP63/AHI1/FGFR2/CTNNB1/BCL2/YIPF6/ASS1/NIPBL 15 GO:1901653 cellular response to peptide 32/998 359/18722 0.00315669695579736 0.0384175170308113 FBN1/APP/ATP2B1/KANK1/GJA1/IGF1R/LRP1/PARP1/FOXO4/PRKDC/GAB1/MDM2/DENND4C/SRSF5/SLC9A1/KLF5/LEPROT/PRKCI/SORBS1/PTPN1/PPARG/AHCYL1/ERRFI1/RAB31/USO1/MYO1C/PTK2/SMARCC1/ASS1/PTPRA/GSK3B/NFE2L2 32 GO:2000146 negative regulation of cell motility 32/998 359/18722 0.00315669695579736 0.0384175170308113 CDH1/TCAF1/ADGRG1/SEMA6D/DAG1/KANK1/FBLN1/DPP4/SERPINF1/DLG5/GJA1/SPINT2/NR2F2/NF1/LRP1/CALR/GNA12/ATP2B4/TACSTD2/CCDC125/MARVELD3/STK26/S1PR2/MIA3/PPARG/PTPRM/GATA3/BCL2/SRGAP1/PHLDB2/CTNNA1/NFE2L2 32 GO:0051492 regulation of stress fiber assembly 12/998 91/18722 0.00318853110962916 0.0387146998217996 MET/NRP1/CD47/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/PHLDB2 12 GO:0034968 histone lysine methylation 14/998 115/18722 0.00321541459758907 0.0389505327471289 BRD4/DNMT1/ASH1L/ATRX/TET2/SMYD2/SETD2/SUZ12/NSD1/RIF1/CTNNB1/KMT2C/GATA3/LMNA 14 GO:0030177 positive regulation of Wnt signaling pathway 16/998 140/18722 0.00324738572785524 0.0392467613081764 EGFR/LGR5/WLS/KANK1/LGR4/TBL1X/YAP1/USP47/ATP6V1C2/MACF1/VCP/FGFR2/USP34/TNKS2/UBR5/GPC3 16 GO:0071214 cellular response to abiotic stimulus 30/998 331/18722 0.0032753247837486 0.0394020062118697 EGFR/MME/SLC2A1/DAG1/HSPA5/GJA1/DDB1/PARP1/TMEM150C/YAP1/OPN3/NET1/MDM2/ADIRF/USP47/TLR3/CLN3/SLC9A1/FMR1/NEDD4/EIF2AK4/ERRFI1/MAPK14/DHX36/SLC38A2/GATA3/PLEC/NIPBL/XPC/YY1 30 GO:0104004 cellular response to environmental stimulus 30/998 331/18722 0.0032753247837486 0.0394020062118697 EGFR/MME/SLC2A1/DAG1/HSPA5/GJA1/DDB1/PARP1/TMEM150C/YAP1/OPN3/NET1/MDM2/ADIRF/USP47/TLR3/CLN3/SLC9A1/FMR1/NEDD4/EIF2AK4/ERRFI1/MAPK14/DHX36/SLC38A2/GATA3/PLEC/NIPBL/XPC/YY1 30 GO:0007422 peripheral nervous system development 11/998 80/18722 0.00335710454047113 0.0402682188667876 ITGB4/DAG1/NF1/SLC5A3/ERBB3/ISL1/DICER1/PARD3/ADGRG6/PLEC/GPC1 11 GO:1904292 regulation of ERAD pathway 5/998 20/18722 0.00337633408900723 0.0402682188667876 USP25/BCAP31/NFE2L2/USP14/TMEM259 5 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 15/998 128/18722 0.00338350133901549 0.0402682188667876 FBN2/FBN1/PEG10/HSPA5/GLG1/TGFBR3/ZNF451/TRIM33/FOLR1/FERMT1/NREP/LATS2/PPARG/CDKN1C/EID2 15 GO:0010559 regulation of glycoprotein biosynthetic process 9/998 58/18722 0.00338589313972798 0.0402682188667876 PAWR/TMEM59/NCSTN/CTNNB1/AGO2/TCF7L2/BCL2/GOLGA2/ARFGEF1 9 GO:2000649 regulation of sodium ion transmembrane transporter activity 9/998 58/18722 0.00338589313972798 0.0402682188667876 UTRN/FXYD3/ANK3/DMD/SLC9A1/NEDD4/ACTN4/STOM/GPD1L 9 GO:0045665 negative regulation of neuron differentiation 10/998 69/18722 0.00344046591712657 0.040824255802995 APP/BMP7/SLC6A4/PBX1/CALR/ISL1/GLI3/SPAG9/EIF2AK4/GSK3B 10 GO:0035967 cellular response to topologically incorrect protein 14/998 116/18722 0.00348210380674379 0.0411713499964488 HSPA5/HSPD1/ERLEC1/DNAJB14/CREB3L2/CCND1/MBTPS1/UFL1/PTPN1/VCP/HSPA1B/ATF6/NFE2L2/HSPA9 14 GO:0016571 histone methylation 16/998 141/18722 0.00348680888308422 0.0411713499964488 BRD4/DNMT1/ASH1L/ATRX/TET2/SMYD2/SETD2/SUZ12/NSD1/PAXBP1/RIF1/CTNNB1/KMT2C/GATA3/PRDM2/LMNA 16 GO:0031058 positive regulation of histone modification 12/998 92/18722 0.0034933744586146 0.0411713499964488 BRD4/DNMT1/ISL1/RPS6KA5/FMR1/BRD7/PAXBP1/RIF1/CTNNB1/GATA3/NIPBL/LMNA 12 GO:0007605 sensory perception of sound 17/998 154/18722 0.00353597485393628 0.041542443532674 LRP2/TBL1X/USP53/PGAP1/ALDH7A1/HEXB/TFAP2A/ATP6V1B1/MYO7A/SLC1A3/TRIOBP/NAV2/SLC52A3/NIPBL/MYO6/MARVELD2/NDUFB9 17 GO:0031960 response to corticosteroid 18/998 167/18722 0.00354077521012066 0.041542443532674 EGFR/AGL/ATP2B1/SERPINF1/PARP1/CTSV/HSPD1/ISL1/CCND1/KRAS/CDO1/ERRFI1/BCL2/ASS1/ALAD/ANXA3/GLB1/HNRNPU 18 GO:0044403 biological process involved in symbiotic interaction 27/998 290/18722 0.00355141352310306 0.0415738340899576 EGFR/CD46/CTSL/DAG1/NRP1/ITGAV/DPP4/TFRC/ITGB5/ITGB1/DDB1/P4HB/CD55/ANO6/SLC52A1/HSPD1/BSG/SLC1A5/FMR1/UVRAG/EIF2AK4/SLC20A2/WWP1/HSPA1B/STOM/SLC52A2/PPIB 27 GO:0001942 hair follicle development 11/998 81/18722 0.00370207437943211 0.0429276543927379 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/BCL2/HDAC2 11 GO:0010833 telomere maintenance via telomere lengthening 11/998 81/18722 0.00370207437943211 0.0429276543927379 PARP1/RAD50/MAP3K4/DCP2/PKIB/HSP90AA1/CTNNB1/DHX36/TNKS2/HNRNPU/HNRNPA2B1 11 GO:0060968 regulation of gene silencing 11/998 81/18722 0.00370207437943211 0.0429276543927379 EGFR/KCNQ1OT1/DNMT1/LIN28B/TPR/PUM1/EIF4G1/MPHOSPH8/FMR1/PPARG/AGO2 11 GO:0006479 protein methylation 19/998 181/18722 0.00373128435896521 0.0429276543927379 BRD4/DNMT1/ASH1L/ATRX/TET2/SMYD2/RAB6A/SETD2/SUZ12/NSD1/PAXBP1/RIF1/CTNNB1/KMT2C/GATA3/PRDM2/PCMTD1/PCMTD2/LMNA 19 GO:0008213 protein alkylation 19/998 181/18722 0.00373128435896521 0.0429276543927379 BRD4/DNMT1/ASH1L/ATRX/TET2/SMYD2/RAB6A/SETD2/SUZ12/NSD1/PAXBP1/RIF1/CTNNB1/KMT2C/GATA3/PRDM2/PCMTD1/PCMTD2/LMNA 19 GO:0030970 retrograde protein transport, ER to cytosol 6/998 29/18722 0.00373283951241199 0.0429276543927379 HSP90B1/ERLEC1/BCAP31/VCP/SEL1L/UBE2G2 6 GO:0060441 epithelial tube branching involved in lung morphogenesis 6/998 29/18722 0.00373283951241199 0.0429276543927379 DAG1/DLG5/YAP1/KRAS/FGFR2/CTNNB1 6 GO:1903513 endoplasmic reticulum to cytosol transport 6/998 29/18722 0.00373283951241199 0.0429276543927379 HSP90B1/ERLEC1/BCAP31/VCP/SEL1L/UBE2G2 6 GO:0016482 cytosolic transport 18/998 168/18722 0.0037738112298219 0.0433034471008794 RHOBTB3/CLTC/EEA1/SYT7/HOOK2/SPAG9/CLN3/ERC1/TMEM87A/RAB6A/VPS13A/EZR/GCC2/RDX/AKTIP/EVI5/ARL1/VPS35 18 GO:0006767 water-soluble vitamin metabolic process 9/998 59/18722 0.00381054440875262 0.0436290621888101 SLC2A1/SLC19A1/MTR/SLC52A1/SLC19A3/FOLR1/AASDHPPT/SLC52A3/SLC52A2 9 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 4/998 13/18722 0.00389531471331585 0.0441159178269458 BRD4/CTNNB1/TCERG1/ELL 4 GO:0035331 negative regulation of hippo signaling 4/998 13/18722 0.00389531471331585 0.0441159178269458 DLG5/MAPK14/VGLL4/SHANK2 4 GO:0098814 spontaneous synaptic transmission 4/998 13/18722 0.00389531471331585 0.0441159178269458 APP/ITGB1/PPP1R9A/NSG1 4 GO:1900115 extracellular regulation of signal transduction 4/998 13/18722 0.00389531471331585 0.0441159178269458 FBN2/FBN1/CD46/LRPAP1 4 GO:1900116 extracellular negative regulation of signal transduction 4/998 13/18722 0.00389531471331585 0.0441159178269458 FBN2/FBN1/CD46/LRPAP1 4 GO:0042476 odontogenesis 15/998 130/18722 0.00392316516648487 0.0443351630610768 LAMB1/LAMA5/BMP7/CSF3R/PERP/TFAP2A/GLI3/ANKRD11/TP63/BSG/FGFR2/CTNNB1/SP6/CTNNA1/HDAC2 15 GO:0032868 response to insulin 25/998 264/18722 0.00394276826237893 0.0444604602546012 SLC2A1/ATP2B1/KANK1/IGF1R/PARP1/FOXO4/PRKDC/HADHA/GAB1/GGH/DENND4C/SRSF5/SLC9A1/PRKCI/SORBS1/PTPN1/PPARG/ERRFI1/RAB31/USO1/MYO1C/SMARCC1/PTPRA/GSK3B/SRSF4 25 GO:0006865 amino acid transport 16/998 143/18722 0.00400931718513086 0.0451134591025177 ITGB1/GJA1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC7A6/SLC16A2/CLN3/SLC1A5/SLC7A2/SLC1A3/SLC38A2/SLC17A5/SERINC3/SLC38A10 16 GO:0022612 gland morphogenesis 14/998 118/18722 0.00406966561588373 0.0455878057930882 DAG1/NRP1/LAMA5/BMP7/LRP5/TGM2/GLI3/KDM5B/TP63/FGFR2/DDR1/PLXNA1/BCL2/BTBD7 14 GO:0060964 regulation of gene silencing by miRNA 8/998 49/18722 0.00407766812973993 0.0455878057930882 EGFR/KCNQ1OT1/LIN28B/PUM1/EIF4G1/FMR1/PPARG/AGO2 8 GO:0072091 regulation of stem cell proliferation 8/998 49/18722 0.00407766812973993 0.0455878057930882 FBLN1/GJA1/YAP1/N4BP2L2/FERMT1/FERMT2/LTBP3/HNRNPU 8 GO:0046326 positive regulation of glucose import 7/998 39/18722 0.0041186926468923 0.0458500944763853 OPN3/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 7 GO:0090224 regulation of spindle organization 7/998 39/18722 0.0041186926468923 0.0458500944763853 CLTC/DYNC1H1/TPR/GNAI1/HSPA1B/GPSM2/HNRNPU 7 GO:0001738 morphogenesis of a polarized epithelium 12/998 94/18722 0.00417351268362971 0.0460674624127499 LAMA5/DLG5/ZNRF3/DVL3/FAT1/TP63/AHI1/RYK/FZD6/DAAM1/OPHN1/GPC3 12 GO:0014020 primary neural tube formation 12/998 94/18722 0.00417351268362971 0.0460674624127499 LRP2/SPINT1/BMP7/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/SETD2/FZD6/ST14 12 GO:1902414 protein localization to cell junction 12/998 94/18722 0.00417351268362971 0.0460674624127499 DSP/DAG1/DLG5/DLG1/MPP7/FERMT2/MARVELD3/TJP1/LSR/CLSTN1/JAM3/NSG1 12 GO:1990830 cellular response to leukemia inhibitory factor 12/998 94/18722 0.00417351268362971 0.0460674624127499 NRP2/TFRC/TLE4/PCOLCE2/KDM5B/KLF5/SMARCA5/RIF1/ARID5B/B3GNT2/EPS8/HNRNPU 12 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 15/998 131/18722 0.00421824467886085 0.0463139740675449 FBN2/FBN1/PEG10/HSPA5/GLG1/TGFBR3/ZNF451/TRIM33/FOLR1/FERMT1/NREP/LATS2/PPARG/CDKN1C/EID2 15 GO:0007063 regulation of sister chromatid cohesion 5/998 21/18722 0.00423953322920844 0.0463139740675449 ATRX/SFPQ/RAD21/CTNNB1/WAPL 5 GO:0150105 protein localization to cell-cell junction 5/998 21/18722 0.00423953322920844 0.0463139740675449 DSP/DLG5/MPP7/TJP1/LSR 5 GO:0003281 ventricular septum development 10/998 71/18722 0.00424625216030944 0.0463139740675449 LRP2/LMO4/GJA5/TGFBR3/TRIP11/MDM2/HECTD1/TGFBR1/FGFR2/GATA3 10 GO:0150116 regulation of cell-substrate junction organization 10/998 71/18722 0.00424625216030944 0.0463139740675449 NRP1/LRP1/SLK/SLC9A1/FERMT2/MACF1/MMP14/PTK2/PTPRA/PHLDB2 10 GO:0062197 cellular response to chemical stress 30/998 337/18722 0.0042490698292193 0.0463139740675449 EGFR/MET/SLC2A1/BMP7/P4HB/ARL6IP5/PARP1/FUT8/NET1/MDM2/CLN3/SFPQ/STK26/PAWR/NFE2L1/PLA2R1/GPX8/ERRFI1/PLEKHA1/CTNNB1/BCL2/ATP2A2/PLEC/HSPA1B/SOD3/CHD6/OXR1/HDAC2/NFE2L2/PAGE4 30 GO:0031102 neuron projection regeneration 9/998 60/18722 0.00427577434908304 0.0464183056165726 DAG1/LRP1/MTR/FOLR1/ISL1/NREP/JAM3/BCL2/CTNNA1 9 GO:0051604 protein maturation 27/998 294/18722 0.00427642309932416 0.0464183056165726 MME/CTSL/ASPH/PERP/ENPEP/GLG1/PARP1/PISD/CALR/SERPINH1/HSPD1/MDM2/LPCAT3/GLI3/CLN3/PRDX4/CPD/DHCR24/PRSS12/TMEM59/NCSTN/AFG3L2/CAST/MMP14/PCSK7/SPPL3/YME1L1 27 GO:0140058 neuron projection arborization 6/998 30/18722 0.00445918017102304 0.0483016175786541 LRP2/NRP1/DVL3/MACF1/TPBG/MAP3K13 6 GO:0042303 molting cycle 13/998 107/18722 0.00451191377251214 0.0486708715005907 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/PPP1R13L/BCL2/NIPBL/HDAC2 13 GO:0042633 hair cycle 13/998 107/18722 0.00451191377251214 0.0486708715005907 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/PPP1R13L/BCL2/NIPBL/HDAC2 13 GO:0007249 I-kappaB kinase/NF-kappaB signaling 26/998 281/18722 0.00452619369031653 0.0486933112637203 WLS/TFRC/GJA1/HACD3/BRD4/TGM2/TMED4/ASH1L/TLR3/SLC44A2/ERC1/USP10/PRDX4/UFL1/NDFIP2/ANKRD17/ZDHHC17/CTNNB1/DHX36/DDX1/PLK2/TLE1/OTUD7B/TAB3/TFG/SHISA5 26 GO:0030833 regulation of actin filament polymerization 18/998 171/18722 0.00455018631383062 0.0486933112637203 KANK1/RASA1/DLG1/IQGAP2/KANK4/SCIN/PPP1R9A/WASF2/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 18 GO:0036473 cell death in response to oxidative stress 12/998 95/18722 0.00455129973121922 0.0486933112637203 MET/P4HB/ARL6IP5/PARP1/SFPQ/STK26/PAWR/CTNNB1/BCL2/OXR1/NFE2L2/PAGE4 12 GO:1990823 response to leukemia inhibitory factor 12/998 95/18722 0.00455129973121922 0.0486933112637203 NRP2/TFRC/TLE4/PCOLCE2/KDM5B/KLF5/SMARCA5/RIF1/ARID5B/B3GNT2/EPS8/HNRNPU 12 GO:0051258 protein polymerization 27/998 296/18722 0.00468322318035669 0.050002266308062 MET/KANK1/RASA1/CLIP1/AKAP9/DLG1/IQGAP2/KANK4/SCIN/PPP1R9A/COBL/WASF2/CAMSAP2/TRIOBP/HSP90AA1/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/GOLGA2/SPTBN1/ARFGEF1/OCLN/HSPA1B/ADD3 27 GO:1901880 negative regulation of protein depolymerization 10/998 72/18722 0.0047013545733496 0.0500934127090985 LIMA1/SCIN/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 10 GO:0030866 cortical actin cytoskeleton organization 7/998 40/18722 0.0047672239700057 0.0506651982346628 DLG1/CALR/FMNL2/EPB41L3/EZR/NCKAP1/PLEC 7 GO:0030865 cortical cytoskeleton organization 9/998 61/18722 0.00478412999994039 0.0506651982346628 DLG1/RHOBTB3/CALR/FMNL2/EPB41L3/EZR/NCKAP1/RND3/PLEC 9 GO:1904356 regulation of telomere maintenance via telomere lengthening 9/998 61/18722 0.00478412999994039 0.0506651982346628 PARP1/MAP3K4/DCP2/PKIB/CTNNB1/DHX36/TNKS2/HNRNPU/HNRNPA2B1 9 GO:0022404 molting cycle process 11/998 84/18722 0.00490967716588076 0.0517846959253807 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/BCL2/HDAC2 11 GO:0022405 hair cycle process 11/998 84/18722 0.00490967716588076 0.0517846959253807 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/BCL2/HDAC2 11 GO:0071478 cellular response to radiation 19/998 186/18722 0.00501958816880234 0.0528372375591069 MME/HSPA5/DDB1/PARP1/YAP1/OPN3/NET1/MDM2/ADIRF/USP47/FMR1/NEDD4/EIF2AK4/MAPK14/DHX36/GATA3/NIPBL/XPC/YY1 19 GO:0035637 multicellular organismal signaling 17/998 160/18722 0.00521708762179739 0.0538431634763787 DSP/ATP2B1/DSC2/AKAP9/GJA1/GJA5/DSG2/ANK3/ATP2B4/ISL1/SLC9A1/FMR1/P2RX4/JAM3/PKP2/ATP2A2/PLEC 17 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 4/998 14/18722 0.0052256735175751 0.0538431634763787 KANK1/FBLN1/TACSTD2/ACTN4 4 GO:0060576 intestinal epithelial cell development 4/998 14/18722 0.0052256735175751 0.0538431634763787 YAP1/IL6ST/KLF5/YIPF6 4 GO:0070141 response to UV-A 4/998 14/18722 0.0052256735175751 0.0538431634763787 EGFR/MME/OPN3/CCND1 4 GO:0072160 nephron tubule epithelial cell differentiation 4/998 14/18722 0.0052256735175751 0.0538431634763787 CD24/YAP1/CTNNB1/GATA3 4 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/998 14/18722 0.0052256735175751 0.0538431634763787 KANK1/FBLN1/TACSTD2/ACTN4 4 GO:1902036 regulation of hematopoietic stem cell differentiation 4/998 14/18722 0.0052256735175751 0.0538431634763787 PRKDC/N4BP2L2/NFE2L2/HSPA9 4 GO:0000082 G1/S transition of mitotic cell cycle 21/998 214/18722 0.00524012797983354 0.0538431634763787 EGFR/ITGB1/BRD4/DLG1/CDK6/ADAMTS1/PRKDC/CTDSPL/SKP2/MDM2/CCND1/EIF4G1/ANKRD17/LATS2/WEE1/BRD7/RDX/BCL2/PLK2/CUL5/BCAT1 21 GO:0001889 liver development 16/998 147/18722 0.00524722706583661 0.0538431634763787 EGFR/MET/NF1/TGFBR3/GLI3/SRSF5/COBL/CCND1/LSR/SEC63/KRAS/ARID5B/MAN2A1/ASS1/PRKCSH/KRT18 16 GO:1902850 microtubule cytoskeleton organization involved in mitosis 16/998 147/18722 0.00524722706583661 0.0538431634763787 ITGB1/GJA1/CLTC/DYNC1H1/TACC2/TPR/SETD2/VCP/GNAI1/GOLGA2/PLK2/MAP4/HSPA1B/STAG1/GPSM2/HNRNPU 16 GO:0045048 protein insertion into ER membrane 5/998 22/18722 0.00524921858063144 0.0538431634763787 CCDC47/EMC1/TRAM2/EMC10/EMC7 5 GO:0140467 integrated stress response signaling 5/998 22/18722 0.00524921858063144 0.0538431634763787 HSPA5/EIF2AK1/PTPN1/EIF2AK4/NFE2L2 5 GO:2000114 regulation of establishment of cell polarity 5/998 22/18722 0.00524921858063144 0.0538431634763787 KANK1/DOCK8/GATA3/ARFGEF1/FLOT2 5 GO:0071711 basement membrane organization 6/998 31/18722 0.00528453195728983 0.0539932316027597 LAMB1/DAG1/ITGB1/SPINT2/FERMT1/PHLDB2 6 GO:1900027 regulation of ruffle assembly 6/998 31/18722 0.00528453195728983 0.0539932316027597 KANK1/TACSTD2/COBL/SH3YL1/RDX/EPS8 6 GO:0046824 positive regulation of nucleocytoplasmic transport 9/998 62/18722 0.00533820991919387 0.0542233346072202 CDH1/MDM2/GLI3/TPR/NEDD4/MAPK14/TCF7L2/UBR5/GSK3B 9 GO:0046847 filopodium assembly 9/998 62/18722 0.00533820991919387 0.0542233346072202 ITGB4/NRP1/FNBP1L/PPP1R9A/CLN3/S1PR2/EZR/FMR1/TGFBR1 9 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 9/998 62/18722 0.00533820991919387 0.0542233346072202 DAG1/DLG1/CTNND1/PRKCI/CLSTN1/EPS8/FLOT2/OPHN1/NSG1 9 GO:0098773 skin epidermis development 11/998 85/18722 0.00537502725094495 0.0544912956838516 EGFR/LGR5/LAMA5/LGR4/FERMT1/TP63/FZD6/FGFR2/CTNNB1/BCL2/HDAC2 11 GO:0014909 smooth muscle cell migration 12/998 97/18722 0.00538875804521324 0.0545246235543766 SEMA6D/NRP1/ADAMTS1/LRP1/FOXO4/GNA12/MDM2/S1PR2/DDR1/PLXNA1/BCL2/NFE2L2 12 GO:0048562 embryonic organ morphogenesis 26/998 285/18722 0.00543832593487209 0.0549197286382344 FBN2/FBN1/EFEMP1/BMP7/DLG1/YAP1/TFAP2A/FOLR1/EFNA1/GLI3/ATP6V1B1/MYO7A/AHI1/TGFBR1/SETD2/TRIOBP/FZD6/SLC39A1/FGFR2/CTNNB1/FZD5/MMP14/GATA3/ALDH1A3/NIPBL/MYO6 26 GO:0051693 actin filament capping 7/998 41/18722 0.00548972928416145 0.0552251957468341 SCIN/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 7/998 41/18722 0.00548972928416145 0.0552251957468341 NRP1/P4HB/CALR/FERMT2/TRIOBP/DOCK1/NEDD9 7 GO:0016358 dendrite development 23/998 243/18722 0.00557374984373031 0.0559625921809923 APP/NRP1/BMP7/DLG5/ITGB1/CUX1/RERE/PPP1R9A/OBSL1/EFNA1/COBL/CDKL5/FMR1/TPBG/NEDD4/KIDINS220/CAMSAP2/TMEM106B/DHX36/PLK2/RBFOX2/GSK3B/HDAC2 23 GO:0006575 cellular modified amino acid metabolic process 19/998 188/18722 0.0056281217041992 0.056400044947455 ARL6IP5/IDH1/SLC19A1/ALDH7A1/PCYOX1/GGH/FOLR1/LPCAT3/CROT/SLC16A2/SERINC2/CPT2/AASDHPPT/PTDSS1/GCNT4/GATA3/ASS1/SERINC3/NFE2L2 19 GO:0060537 muscle tissue development 34/998 403/18722 0.005641473706618 0.0564255444870739 LRP2/DSP/BMP7/ITGB1/GJA1/NR2F2/DLG1/NF1/GJA5/DSG2/TGFBR3/CALR/YAP1/DMD/ISL1/OBSL1/DDX17/SLC9A1/KLF5/HOMER1/TGFBR1/MSX2/MAPK14/FGFR2/VGLL4/CTNNB1/PKP2/PPP1R13L/BCL2/PLEC/GPC1/YY1/LMNA/HNRNPU 34 GO:0014812 muscle cell migration 13/998 110/18722 0.00570845591288751 0.0569435380426869 SEMA6D/NRP1/ADAMTS1/LRP1/FOXO4/GNA12/NET1/MDM2/S1PR2/DDR1/PLXNA1/BCL2/NFE2L2 13 GO:0030968 endoplasmic reticulum unfolded protein response 10/998 74/18722 0.00572598304393997 0.0569435380426869 HSPA5/ERLEC1/CREB3L2/CCND1/MBTPS1/UFL1/PTPN1/VCP/ATF6/NFE2L2 10 GO:1903201 regulation of oxidative stress-induced cell death 10/998 74/18722 0.00572598304393997 0.0569435380426869 MET/P4HB/PARP1/SFPQ/STK26/PAWR/CTNNB1/OXR1/NFE2L2/PAGE4 10 GO:0050954 sensory perception of mechanical stimulus 18/998 175/18722 0.00578508848841195 0.0574219524676784 LRP2/TBL1X/USP53/PGAP1/ALDH7A1/HEXB/TFAP2A/ATP6V1B1/MYO7A/SLC1A3/P2RX4/TRIOBP/NAV2/SLC52A3/NIPBL/MYO6/MARVELD2/NDUFB9 18 GO:0006913 nucleocytoplasmic transport 27/998 301/18722 0.00584413884499847 0.0575302089227097 CDH1/CALR/PTPN14/PTTG1IP/MDM2/FERMT1/GLI3/TNPO1/TPR/NEDD4/SETD2/AHCYL1/MAPK14/NEMF/RANBP17/IPO7/TCF7L2/RANBP2/UBR5/GSK3B/LSG1/PPP1R10/LMNA/AGFG1/PABPN1/HSPA9/HNRNPA2B1 27 GO:0051169 nuclear transport 27/998 301/18722 0.00584413884499847 0.0575302089227097 CDH1/CALR/PTPN14/PTTG1IP/MDM2/FERMT1/GLI3/TNPO1/TPR/NEDD4/SETD2/AHCYL1/MAPK14/NEMF/RANBP17/IPO7/TCF7L2/RANBP2/UBR5/GSK3B/LSG1/PPP1R10/LMNA/AGFG1/PABPN1/HSPA9/HNRNPA2B1 27 GO:0003333 amino acid transmembrane transport 12/998 98/18722 0.00585109000918576 0.0575302089227097 ITGB1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC7A6/SLC16A2/SLC1A5/SLC7A2/SLC1A3/SLC38A2/SLC38A10 12 GO:0061337 cardiac conduction 12/998 98/18722 0.00585109000918576 0.0575302089227097 DSP/ATP2B1/DSC2/AKAP9/GJA1/GJA5/DSG2/ATP2B4/ISL1/SLC9A1/PKP2/ATP2A2 12 GO:1902882 regulation of response to oxidative stress 12/998 98/18722 0.00585109000918576 0.0575302089227097 MET/BMP7/P4HB/PARP1/FUT8/SFPQ/STK26/PAWR/CTNNB1/OXR1/NFE2L2/PAGE4 12 GO:0014031 mesenchymal cell development 11/998 86/18722 0.00587449352063608 0.0576056100863159 NRP2/SEMA6A/SEMA6D/NRP1/LAMA5/BMP7/FOLR1/ISL1/SEMA3F/SEMA4B/BCL2 11 GO:0003231 cardiac ventricle development 14/998 123/18722 0.00589605156919553 0.0576056100863159 LRP2/DSP/LMO4/GJA5/TGFBR3/TRIP11/MDM2/ISL1/HECTD1/TGFBR1/FGFR2/PKP2/PPP1R13L/GATA3 14 GO:0010811 positive regulation of cell-substrate adhesion 14/998 123/18722 0.00589605156919553 0.0576056100863159 ITGA6/DAG1/NRP1/UTRN/CCDC80/P4HB/CDK6/CALR/FERMT1/FERMT2/TRIOBP/DOCK1/NEDD9/GSK3B 14 GO:0010718 positive regulation of epithelial to mesenchymal transition 8/998 52/18722 0.00591392587746894 0.0576056100863159 BMP7/GCNT2/ISL1/FERMT2/TGFBR1/CTNNB1/TCF7L2/HDAC2 8 GO:0060147 regulation of posttranscriptional gene silencing 8/998 52/18722 0.00591392587746894 0.0576056100863159 EGFR/KCNQ1OT1/LIN28B/PUM1/EIF4G1/FMR1/PPARG/AGO2 8 GO:0090288 negative regulation of cellular response to growth factor stimulus 13/998 111/18722 0.00615926755717153 0.0596838244350622 FBN1/LRP2/SEMA6A/CRIM1/TRIM33/ATP2B4/EPN2/NEDD4/PTPN1/PPARG/PIK3CB/GATA3/GPC1 13 GO:0010039 response to iron ion 6/998 32/18722 0.00621637685841299 0.0596838244350622 TFAP2A/MDM2/CCND1/BCL2/ACO1/ALAD 6 GO:0021799 cerebral cortex radially oriented cell migration 6/998 32/18722 0.00621637685841299 0.0596838244350622 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:0033687 osteoblast proliferation 6/998 32/18722 0.00621637685841299 0.0596838244350622 ITGAV/LRP5/PLXNB1/FGFR2/BCL2/ATRAID 6 GO:0048841 regulation of axon extension involved in axon guidance 6/998 32/18722 0.00621637685841299 0.0596838244350622 SEMA6A/SEMA6D/NRP1/SEMA3F/RYK/SEMA4B 6 GO:1905476 negative regulation of protein localization to membrane 6/998 32/18722 0.00621637685841299 0.0596838244350622 CLTC/HECTD1/PPFIA1/TMEM59/GOPC/LYPLA1 6 GO:0034599 cellular response to oxidative stress 26/998 288/18722 0.00621873213803368 0.0596838244350622 EGFR/MET/BMP7/P4HB/ARL6IP5/PARP1/FUT8/NET1/MDM2/SFPQ/STK26/PAWR/NFE2L1/PLA2R1/GPX8/PLEKHA1/CTNNB1/BCL2/ATP2A2/HSPA1B/SOD3/CHD6/OXR1/HDAC2/NFE2L2/PAGE4 26 GO:1903311 regulation of mRNA metabolic process 26/998 288/18722 0.00621873213803368 0.0596838244350622 MBNL3/FUS/RBM39/SON/SF1/DDX17/PUM1/MBNL2/RBM25/DCP2/RBM5/FMR1/AHCYL1/MAPK14/TRA2B/DHX36/AGO2/RBFOX2/TNRC6A/SECISBP2/ZC3H14/QKI/SRSF4/TIA1/HNRNPU/SRSF2 26 GO:0009755 hormone-mediated signaling pathway 19/998 190/18722 0.00629579097885757 0.060128604413777 LGR5/BMP7/LGR4/PARP1/PRLR/CALR/YAP1/SKP2/ISL1/ESRRG/DDX17/TP63/UFL1/LATS2/NEDD4/PPARG/UBR5/RBFOX2/TMF1 19 GO:0030041 actin filament polymerization 19/998 190/18722 0.00629579097885757 0.060128604413777 KANK1/RASA1/DLG1/IQGAP2/KANK4/SCIN/PPP1R9A/COBL/WASF2/TRIOBP/MYO1C/ARHGAP18/RDX/NCKAP1/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 19 GO:0006024 glycosaminoglycan biosynthetic process 10/998 75/18722 0.00629962585986133 0.060128604413777 CLTC/CHPF/GCNT2/HS6ST2/B3GNT3/GLCE/HEXA/B3GNT2/EXT2/B4GAT1 10 GO:0010717 regulation of epithelial to mesenchymal transition 12/998 99/18722 0.00634430596566608 0.0604445646838369 DAG1/BMP7/GCNT2/ISL1/EFNA1/FERMT2/TGFBR1/CTNNB1/TCF7L2/GATA3/PHLDB2/HDAC2 12 GO:0060048 cardiac muscle contraction 15/998 137/18722 0.0063911071894906 0.0604820609430678 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/DMD/SLC9A1/P2RX4/PKP2/GAA/PPP1R13L/ATP2A2/GPD1L 15 GO:0071383 cellular response to steroid hormone stimulus 20/998 204/18722 0.00640104641188768 0.0604820609430678 EGFR/ATP2B1/BMP7/SERPINF1/PARP1/CALR/YAP1/SKP2/ISL1/ESRRG/DDX17/TP63/UFL1/NEDD4/ERRFI1/UBR5/ASS1/RBFOX2/TMF1/HNRNPU 20 GO:1900182 positive regulation of protein localization to nucleus 11/998 87/18722 0.00640974567596151 0.0604820609430678 CDH1/TFRC/PARP1/YAP1/GLI3/TPR/LIMK2/FERMT2/CD2AP/MAPK14/UBR5 11 GO:0035994 response to muscle stretch 5/998 23/18722 0.00641774789551035 0.0604820609430678 DMD/SLC9A1/MAPK14/CTNNB1/PTK2 5 GO:0042026 protein refolding 5/998 23/18722 0.00641774789551035 0.0604820609430678 HSPA5/HSPD1/HSP90AA1/HSPA1B/HSPA9 5 GO:2000737 negative regulation of stem cell differentiation 5/998 23/18722 0.00641774789551035 0.0604820609430678 YAP1/N4BP2L2/NFE2L2/HSPA9/HNRNPU 5 GO:0030104 water homeostasis 9/998 64/18722 0.00659415870409891 0.0618098789840222 MET/CLDN4/ATP6V1B1/CLN3/TP63/LSR/GRHL1/EXT2/PLEC 9 GO:0045995 regulation of embryonic development 9/998 64/18722 0.00659415870409891 0.0618098789840222 DAG1/LAMA5/AMOT/CTNNB1/DHX36/NIPBL/PHLDB2/NFE2L2/PHLDA2 9 GO:1903018 regulation of glycoprotein metabolic process 9/998 64/18722 0.00659415870409891 0.0618098789840222 PAWR/TMEM59/NCSTN/CTNNB1/AGO2/TCF7L2/BCL2/GOLGA2/ARFGEF1 9 GO:0048640 negative regulation of developmental growth 13/998 112/18722 0.00663797145753605 0.0620280908421703 SEMA6A/SEMA6D/NRP1/SLC6A4/ADRB1/GJA1/SPAG9/RTN4/SEMA3F/RYK/VGLL4/SEMA4B/YY1 13 GO:0060966 regulation of gene silencing by RNA 8/998 53/18722 0.00664769864391984 0.0620280908421703 EGFR/KCNQ1OT1/LIN28B/PUM1/EIF4G1/FMR1/PPARG/AGO2 8 GO:0050821 protein stabilization 19/998 191/18722 0.00665308003670089 0.0620280908421703 TBL1X/CTNND1/AAK1/CALR/PLPP3/DVL3/HSPD1/USP27X/EFNA1/TRIM44/USP9X/RTN4/HSP90AA1/SEL1L/HSPA1B/P3H1/CDK7/FLOT2/PPIB 19 GO:2001236 regulation of extrinsic apoptotic signaling pathway 16/998 151/18722 0.00677916546917241 0.0625502785176914 ITGA6/NRP1/ITGAV/IFI6/PDIA3/YAP1/SIAH2/BIRC6/TGFBR1/TCF7L2/BCL2/HSPA1B/GSK3B/PMAIP1/CTNNA1/LMNA 16 GO:0035107 appendage morphogenesis 15/998 138/18722 0.00682793586076558 0.0625502785176914 FBN2/BMP7/PBX1/LRP5/FRAS1/TFAP2A/GLI3/ATRX/TP63/FZD6/FGFR2/CTNNB1/NIPBL/GPC3/HDAC2 15 GO:0035108 limb morphogenesis 15/998 138/18722 0.00682793586076558 0.0625502785176914 FBN2/BMP7/PBX1/LRP5/FRAS1/TFAP2A/GLI3/ATRX/TP63/FZD6/FGFR2/CTNNB1/NIPBL/GPC3/HDAC2 15 GO:0019511 peptidyl-proline hydroxylation 4/998 15/18722 0.00682889460928637 0.0625502785176914 P4HB/PRDX4/P3H2/P3H1 4 GO:0033599 regulation of mammary gland epithelial cell proliferation 4/998 15/18722 0.00682889460928637 0.0625502785176914 KDM5B/CCND1/RTN4/GATA3 4 GO:0045176 apical protein localization 4/998 15/18722 0.00682889460928637 0.0625502785176914 DLG5/JAM3/GOPC/RDX 4 GO:0048569 post-embryonic animal organ development 4/998 15/18722 0.00682889460928637 0.0625502785176914 FBN1/EFEMP1/MYO7A/FZD5 4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 4/998 15/18722 0.00682889460928637 0.0625502785176914 BCAP31/TM9SF4/TMEM30B/TMEM30A 4 GO:0098760 response to interleukin-7 4/998 15/18722 0.00682889460928637 0.0625502785176914 P4HB/PDIA3/HSPD1/RAD23B 4 GO:0098761 cellular response to interleukin-7 4/998 15/18722 0.00682889460928637 0.0625502785176914 P4HB/PDIA3/HSPD1/RAD23B 4 GO:0110020 regulation of actomyosin structure organization 12/998 100/18722 0.0068697962761692 0.0628008099487159 MET/NRP1/CD47/TACSTD2/PPP1R9A/PPFIA1/WASF2/SLC9A1/FERMT2/TJP1/TGFBR1/PHLDB2 12 GO:0009266 response to temperature stimulus 18/998 178/18722 0.00688030325429333 0.0628008099487159 ATP2B1/ADRB1/HSPD1/TPR/RBBP7/ACADVL/SLC9A1/DNAJB4/HSP90AA1/EIF2AK4/VCP/DHX36/NR2F6/SLC52A3/ATP2A2/HSPA1B/GSK3B/HDAC2 18 GO:0001843 neural tube closure 11/998 88/18722 0.00698247978768042 0.0636222111195104 LRP2/SPINT1/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/SETD2/FZD6/ST14 11 GO:0008016 regulation of heart contraction 20/998 206/18722 0.00711258492611919 0.0646947837966347 DSP/ATP2B1/DSC2/ADRB1/AKAP9/GJA1/DLG1/GJA5/DSG2/ATP2B4/MDM2/DMD/ISL1/SLC9A1/P2RX4/PKP2/CYP2J2/GAA/ATP2A2/GPD1L 20 GO:0010171 body morphogenesis 7/998 43/18722 0.00717663151358917 0.0648255936547562 DAG1/ANKRD11/ARID5B/PLEKHA1/NIPBL/PHLDB2/GPC3 7 GO:0030517 negative regulation of axon extension 7/998 43/18722 0.00717663151358917 0.0648255936547562 SEMA6A/SEMA6D/NRP1/RTN4/SEMA3F/RYK/SEMA4B 7 GO:0061383 trabecula morphogenesis 7/998 43/18722 0.00717663151358917 0.0648255936547562 FBN2/BMP7/ADAMTS1/TGFBR3/PLXNB1/TGFBR1/ADGRG6 7 GO:0071604 transforming growth factor beta production 7/998 43/18722 0.00717663151358917 0.0648255936547562 CD46/ITGAV/ITGB8/CD24/FERMT1/CD2AP/LTBP3 7 GO:0031056 regulation of histone modification 16/998 152/18722 0.00721354675612306 0.0650465071048679 BRD4/DNMT1/ZNF451/ISL1/ATRX/RPS6KA5/FMR1/NSD1/BRD7/PAXBP1/RIF1/CTNNB1/GATA3/UBR5/NIPBL/LMNA 16 GO:1902475 L-alpha-amino acid transmembrane transport 9/998 65/18722 0.00730142783223439 0.0657254391587857 ITGB1/SLC38A9/SLC43A2/SLC38A1/ARL6IP5/SLC7A6/SLC1A5/SLC7A2/SLC1A3 9 GO:0009314 response to radiation 37/998 456/18722 0.00742440075163111 0.0665883112638349 EGFR/APP/MME/HSPA5/ITGB1/DDB1/NF1/LRP5/PARP1/YAP1/PRKDC/OPN3/NET1/MDM2/ADIRF/DNMT3A/CDS1/USP47/MAP3K4/CCND1/UBE4B/FMR1/NEDD4/SLC1A3/KRAS/EIF2AK4/MAPK14/DHX36/NR2F6/GATA3/BCL2/SDF4/NIPBL/MEIS2/ALAD/XPC/YY1 37 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 23/998 249/18722 0.00743187332696068 0.0665883112638349 WLS/TFRC/GJA1/BRD4/TGM2/TMED4/ASH1L/TLR3/SLC44A2/USP10/UFL1/NDFIP2/ANKRD17/ZDHHC17/CTNNB1/DHX36/DDX1/PLK2/TLE1/OTUD7B/TAB3/TFG/SHISA5 23 GO:0030520 intracellular estrogen receptor signaling pathway 8/998 54/18722 0.00744829990003439 0.0665883112638349 PARP1/YAP1/SKP2/ISL1/DDX17/TP63/UFL1/RBFOX2 8 GO:0086002 cardiac muscle cell action potential involved in contraction 8/998 54/18722 0.00744829990003439 0.0665883112638349 DSP/DSC2/GJA1/DLG1/GJA5/DSG2/PKP2/GPD1L 8 GO:0001666 response to hypoxia 27/998 307/18722 0.00754384183511558 0.0673271764463905 SLC2A1/HSP90B1/BMP7/SLC6A4/DPP4/P4HB/NF1/CD24/TGFBR3/HSPD1/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/TM9SF4/MALAT1/MMP14/BCL2/STC2/SOD3/HILPDA/PMAIP1/ALAD/LMNA/SLC29A1/NFE2L2 27 GO:0014910 regulation of smooth muscle cell migration 11/998 89/18722 0.00759441566207899 0.0675476050625459 SEMA6D/NRP1/ADAMTS1/LRP1/FOXO4/GNA12/MDM2/S1PR2/PLXNA1/BCL2/NFE2L2 11 GO:0060606 tube closure 11/998 89/18722 0.00759441566207899 0.0675476050625459 LRP2/SPINT1/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/SETD2/FZD6/ST14 11 GO:0007265 Ras protein signal transduction 29/998 337/18722 0.00773936631670467 0.0685281892203233 MET/ADGRG1/KANK1/NRP1/RASA1/ITGB1/HACD3/NF1/DNMT1/GNA12/NET1/ABCA1/ARHGAP5/DENND4C/CCDC125/WASF2/DHCR24/CTNNAL1/CYTH3/PIK3CB/KRAS/ARFGEF3/RDX/NCKAP1/EPS8/PLK2/ARFGEF1/GPSM2/OPHN1 29 GO:0003148 outflow tract septum morphogenesis 5/998 24/18722 0.00775716526129307 0.0685281892203233 LRP2/NRP2/NRP1/ISL1/FGFR2 5 GO:0030859 polarized epithelial cell differentiation 5/998 24/18722 0.00775716526129307 0.0685281892203233 DLG5/FAT1/TP63/AHI1/OPHN1 5 GO:0036010 protein localization to endosome 5/998 24/18722 0.00775716526129307 0.0685281892203233 NRP1/EZR/RDX/TMEM30A/VPS35 5 GO:0031333 negative regulation of protein-containing complex assembly 15/998 140/18722 0.00777328712202084 0.0685546149730925 KANK1/HSPA5/LMO4/KANK4/SCIN/ISL1/TRIOBP/JAM3/RDX/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3/GSK3B 15 GO:0001841 neural tube formation 12/998 102/18722 0.00802326410015522 0.0706399019678084 LRP2/SPINT1/BMP7/SPINT2/LMO4/DVL3/FOLR1/HECTD1/COBL/SETD2/FZD6/ST14 12 GO:0014015 positive regulation of gliogenesis 9/998 66/18722 0.00806520871136758 0.0708896543468857 EGFR/LRP2/SPINT1/DAG1/IL6ST/UFL1/PRKCI/DICER1/HDAC2 9 GO:0071692 protein localization to extracellular region 31/998 368/18722 0.00813274934576605 0.0709512380183835 FBN2/EGFR/FBN1/MYH10/WLS/DPP4/GJA1/LRP5/FAM3B/LRP1/EXPH5/FRMD4A/CCDC186/CANX/KCNN4/CAMK2G/PDIA4/ABCA1/ISL1/SYT7/EXOC1/SLC16A1/CD2AP/ERP29/EZR/MIA3/GNPTAB/SEL1L/TCF7L2/RAB11FIP1/P3H1 31 GO:0050770 regulation of axonogenesis 16/998 154/18722 0.00814931005928282 0.0709512380183835 SEMA6A/SEMA6D/NRP1/GOLGA4/LRP1/EFNA1/PLXNB1/CDKL5/MACF1/RTN4/SEMA3F/RYK/SEMA4B/PLXNA1/GSK3B/MAP3K13 16 GO:0002066 columnar/cuboidal epithelial cell development 7/998 44/18722 0.00815105918692283 0.0709512380183835 CDK6/YAP1/IL6ST/KLF5/YIPF6/GSK3B/FASN 7 GO:0060711 labyrinthine layer development 7/998 44/18722 0.00815105918692283 0.0709512380183835 SPINT1/BMP7/SPINT2/BIRC6/FGFR2/FZD5/ST14 7 GO:0089718 amino acid import across plasma membrane 7/998 44/18722 0.00815105918692283 0.0709512380183835 ITGB1/SLC43A2/ARL6IP5/SLC16A2/SLC1A5/SLC7A2/SLC1A3 7 GO:0003015 heart process 23/998 251/18722 0.008153752693168 0.0709512380183835 DSP/ATP2B1/DSC2/ADRB1/AKAP9/GJA1/DLG1/GJA5/DSG2/YAP1/ATP2B4/MDM2/DMD/ISL1/SLC9A1/P2RX4/PKP2/CYP2J2/GAA/PPP1R13L/EXT2/ATP2A2/GPD1L 23 GO:0042475 odontogenesis of dentin-containing tooth 11/998 90/18722 0.00824729409209168 0.0716457944339611 LAMA5/BMP7/CSF3R/PERP/GLI3/ANKRD11/TP63/BSG/CTNNB1/CTNNA1/HDAC2 11 GO:0042220 response to cocaine 8/998 55/18722 0.00831935876775435 0.0721517809409393 HSPA5/TGM2/HSPD1/MDM2/DNMT3A/HOMER1/SLC1A3/HDAC2 8 GO:0001558 regulation of cell growth 34/998 414/18722 0.00839389628834403 0.0726775000355625 EGFR/SEMA6A/SEMA6D/NRP1/GOLGA4/SMARCA2/GJA1/LRP1/NET1/USP47/RBBP7/CDKL5/NRCAM/SPAG9/SLC9A1/MACF1/EIF4G1/EPB41L3/RTN4/SEMA3F/KIAA1109/TGFBR1/DCBLD2/CLSTN1/RYK/VGLL4/SEMA4B/MMP14/DDR1/BCL2/HSPA1B/GSK3B/MAP3K13/YY1 34 GO:0014706 striated muscle tissue development 32/998 384/18722 0.0084440103674926 0.0729903611401968 LRP2/DSP/BMP7/ITGB1/GJA1/NR2F2/GJA5/DSG2/TGFBR3/CALR/YAP1/DMD/ISL1/OBSL1/DDX17/SLC9A1/KLF5/HOMER1/TGFBR1/MSX2/MAPK14/FGFR2/VGLL4/CTNNB1/PKP2/PPP1R13L/BCL2/PLEC/GPC1/YY1/LMNA/HNRNPU 32 GO:0017014 protein nitrosylation 4/998 16/18722 0.00872643665220357 0.0744456303286844 ATP2B4/DMD/ADH5/OXR1 4 GO:0018119 peptidyl-cysteine S-nitrosylation 4/998 16/18722 0.00872643665220357 0.0744456303286844 ATP2B4/DMD/ADH5/OXR1 4 GO:0019377 glycolipid catabolic process 4/998 16/18722 0.00872643665220357 0.0744456303286844 HEXB/FUCA1/HEXA/GM2A 4 GO:0033631 cell-cell adhesion mediated by integrin 4/998 16/18722 0.00872643665220357 0.0744456303286844 DPP4/ITGB1/PLPP3/SWAP70 4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 4/998 16/18722 0.00872643665220357 0.0744456303286844 TCERG1/NELFCD/HEXIM1/HNRNPU 4 GO:0060572 morphogenesis of an epithelial bud 4/998 16/18722 0.00872643665220357 0.0744456303286844 BMP7/TP63/FGFR2/CTNNB1 4 GO:0061548 ganglion development 4/998 16/18722 0.00872643665220357 0.0744456303286844 NRP2/NRP1/SEMA3F/CTNNB1 4 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 4/998 16/18722 0.00872643665220357 0.0744456303286844 ANK3/DMD/SLC9A1/ACTN4 4 GO:0021782 glial cell development 13/998 116/18722 0.00885545435892998 0.0751777678178429 EGFR/APP/ITGB4/DAG1/CDK6/NF1/LRP1/NCSTN/DICER1/PARD3/KRAS/ADGRG6/PLEC 13 GO:0030326 embryonic limb morphogenesis 13/998 116/18722 0.00885545435892998 0.0751777678178429 FBN2/BMP7/PBX1/LRP5/FRAS1/TFAP2A/GLI3/TP63/FZD6/CTNNB1/NIPBL/GPC3/HDAC2 13 GO:0035113 embryonic appendage morphogenesis 13/998 116/18722 0.00885545435892998 0.0751777678178429 FBN2/BMP7/PBX1/LRP5/FRAS1/TFAP2A/GLI3/TP63/FZD6/CTNNB1/NIPBL/GPC3/HDAC2 13 GO:0021543 pallium development 17/998 169/18722 0.00891051044787951 0.0755223620915242 LAMB1/ADGRG1/SLC2A1/CDK6/NF1/LRP1/ATP2B4/TACC2/GLI3/GNG12/RTN4/TRA2B/CTNNB1/SUN1/SLC38A2/GSK3B/ANXA3 17 GO:0098661 inorganic anion transmembrane transport 11/998 91/18722 0.00894287400218029 0.0756738171237979 SLC26A2/SLC13A4/GABRE/ANO6/PCYOX1/ANKH/SLC12A9/SLC1A3/SLC5A6/GABRA4/SLC20A2 11 GO:0006023 aminoglycan biosynthetic process 10/998 79/18722 0.00905251119094866 0.0763540564264022 CLTC/CHPF/GCNT2/HS6ST2/B3GNT3/GLCE/HEXA/B3GNT2/EXT2/B4GAT1 10 GO:0032272 negative regulation of protein polymerization 10/998 79/18722 0.00905251119094866 0.0763540564264022 KANK1/KANK4/SCIN/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ARFGEF1/ADD3 10 GO:0010001 glial cell differentiation 21/998 225/18722 0.00913803240778553 0.076951076130723 EGFR/APP/SPINT1/ITGB4/DAG1/CDK6/NF1/LRP1/IL6ST/ERBB3/GLI3/NCSTN/DICER1/PARD3/KRAS/CTNNB1/ADGRG6/GPR157/PLEC/GPC1/HDAC2 21 GO:0043491 protein kinase B signaling 20/998 211/18722 0.00917625089372063 0.0770210114046693 EGFR/LRP2/MET/DAG1/ITGB1/DLG1/IGF1R/GCNT2/FERMT2/RTN4/TPBG/TGFBR1/P2RX4/HSP90AA1/PIK3CB/PLEKHA1/TCF7L2/PTK2/GATA3/ARFGEF1 20 GO:0030850 prostate gland development 7/998 45/18722 0.00921948037954899 0.0770210114046693 BMP7/SERPINF1/GLI3/TP63/FGFR2/CTNNB1/SMARCC1 7 GO:0048538 thymus development 7/998 45/18722 0.00921948037954899 0.0770210114046693 PBX1/LMO4/PRKDC/TGFBR1/CTNNB1/GATA3/BCL2 7 GO:0048546 digestive tract morphogenesis 7/998 45/18722 0.00921948037954899 0.0770210114046693 GLI3/TP63/AHI1/FGFR2/CTNNB1/BCL2/NIPBL 7 GO:0031529 ruffle organization 8/998 56/18722 0.00926451367375797 0.0770210114046693 KANK1/LIMA1/TACSTD2/COBL/SH3YL1/PLEKHA1/RDX/EPS8 8 GO:0032878 regulation of establishment or maintenance of cell polarity 5/998 25/18722 0.00927910671778145 0.0770210114046693 KANK1/DOCK8/GATA3/ARFGEF1/FLOT2 5 GO:0060706 cell differentiation involved in embryonic placenta development 5/998 25/18722 0.00927910671778145 0.0770210114046693 SPINT2/NR2F2/HECTD1/FZD5/ST14 5 GO:0090169 regulation of spindle assembly 5/998 25/18722 0.00927910671778145 0.0770210114046693 DYNC1H1/TPR/HSPA1B/GPSM2/HNRNPU 5 GO:1903792 negative regulation of anion transport 5/998 25/18722 0.00927910671778145 0.0770210114046693 GABRE/SLC43A2/ARL6IP5/PLA2R1/GOPC 5 GO:0007517 muscle organ development 28/998 327/18722 0.00934011645714177 0.0774043619408527 LRP2/DSP/DAG1/LAMA5/UTRN/NR2F2/TGFBR3/FOXO4/DMD/ISL1/DDX17/ZFHX3/KLF5/HOMER1/TGFBR1/PAXBP1/MAPK14/FGFR2/ARID5B/CTNNB1/PKP2/ZNF609/BCL2/ASS1/PLEC/EID2/GPC1/CD164 28 GO:0016570 histone modification 37/998 463/18722 0.00936016297498892 0.0774475608437673 NCOA3/DDB1/BRD4/TBL1X/DNMT1/ZNF451/RCOR1/ASH1L/ISL1/KDM5B/ATRX/TET2/HUWE1/RPS6KA5/UFL1/SFPQ/SMYD2/FMR1/SETD2/SUZ12/NSD1/BRD7/PAXBP1/RIF1/CTNNB1/PHF20/KMT2C/BAZ1B/GATA3/USP22/UBR5/KDM4B/PRDM2/NIPBL/BRD8/HDAC2/LMNA 37 GO:0010876 lipid localization 36/998 448/18722 0.00946503582409667 0.0781913798063429 SLC2A1/ITGAV/SLC27A2/MEST/ATP10D/ANO6/LRP1/LIMA1/HEXB/KCNN4/ABCA1/CDS1/LPCAT3/SYT7/CROT/KDM5B/PLEKHA8/CLN3/OSBPL9/PLA2R1/P2RX4/PPARG/CPT2/TMEM30B/GM2A/HDLBP/ESYT2/ABCB1/SGPP1/TMEM30A/ACSL3/HILPDA/TTPA/TMF1/SQLE/ANXA2 36 GO:0007051 spindle organization 18/998 184/18722 0.00957419848734092 0.0789682311254454 DLG1/CLTC/DYNC1H1/TACC2/ATRX/TPR/LIMK2/EZR/UVRAG/VCP/GNAI1/GOLGA2/PLK2/MAP4/HSPA1B/STAG1/GPSM2/HNRNPU 18 GO:0001893 maternal placenta development 6/998 35/18722 0.00972499290852063 0.0794915481307895 GJA1/NR2F2/CTSV/ASH1L/BSG/STC2 6 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 6/998 35/18722 0.00972499290852063 0.0794915481307895 PARP1/YAP1/SKP2/ISL1/TP63/UFL1 6 GO:0034405 response to fluid shear stress 6/998 35/18722 0.00972499290852063 0.0794915481307895 GJA1/ABCA1/P2RX4/ASS1/PLEC/NFE2L2 6 GO:0071108 protein K48-linked deubiquitination 6/998 35/18722 0.00972499290852063 0.0794915481307895 USP25/USP27X/USP9X/USP34/OTUD4/OTUD7B 6 GO:0086005 ventricular cardiac muscle cell action potential 6/998 35/18722 0.00972499290852063 0.0794915481307895 DSP/DSC2/DLG1/DSG2/PKP2/GPD1L 6 GO:0010812 negative regulation of cell-substrate adhesion 9/998 68/18722 0.00977336891859886 0.0794915481307895 KANK1/FBLN1/RASA1/LRP1/GCNT2/TACSTD2/ACTN4/MMP14/PHLDB2 9 GO:0032922 circadian regulation of gene expression 9/998 68/18722 0.00977336891859886 0.0794915481307895 MAGED1/LGR4/GFPT1/ZFHX3/HUWE1/MYCBP2/BHLHE41/HDAC2/HNRNPU 9 GO:0060411 cardiac septum morphogenesis 9/998 68/18722 0.00977336891859886 0.0794915481307895 LRP2/NRP2/NRP1/BMP7/TGFBR3/MDM2/ISL1/TGFBR1/FGFR2 9 GO:0010038 response to metal ion 31/998 373/18722 0.009774674181185 0.0794915481307895 EGFR/APP/CDH1/SERPINF1/HSPA5/ANK3/PARP1/CALR/FUS/TFAP2A/GGH/MDM2/DNMT3A/SYT7/HSD17B1/SEC31A/CCND1/HOMER1/BSG/NCSTN/TRPV6/NEDD4/P2RX4/AHCYL1/CYB5A/BCL2/ASS1/ACO1/SOD3/ALAD/NFE2L2 31 GO:0044843 cell cycle G1/S phase transition 22/998 241/18722 0.00992867845854102 0.080493214646029 EGFR/ITGB1/BRD4/DLG1/CDK6/ADAMTS1/PRKDC/CTDSPL/ATP2B4/SKP2/MDM2/CCND1/EIF4G1/ANKRD17/LATS2/WEE1/BRD7/RDX/BCL2/PLK2/CUL5/BCAT1 22 GO:0060047 heart contraction 22/998 241/18722 0.00992867845854102 0.080493214646029 DSP/ATP2B1/DSC2/ADRB1/AKAP9/GJA1/DLG1/GJA5/DSG2/ATP2B4/MDM2/DMD/ISL1/SLC9A1/P2RX4/PKP2/CYP2J2/GAA/PPP1R13L/EXT2/ATP2A2/GPD1L 22 GO:0018022 peptidyl-lysine methylation 14/998 131/18722 0.0101303126993516 0.0820005621756817 BRD4/DNMT1/ASH1L/ATRX/TET2/SMYD2/SETD2/SUZ12/NSD1/RIF1/CTNNB1/KMT2C/GATA3/LMNA 14 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 23/998 256/18722 0.0102112082698455 0.0825274278279619 FBN2/FBN1/LRP2/PEG10/CRIM1/BMP7/HSPA5/GLG1/LRP1/PARP1/TGFBR3/ZNF451/TRIM33/FOLR1/FSTL1/FERMT1/NREP/LATS2/TGFBR1/PPARG/CDKN1C/EID2/GPC3 23 GO:0050891 multicellular organismal water homeostasis 8/998 57/18722 0.0102874007024898 0.0830147126239554 MET/CLDN4/ATP6V1B1/TP63/LSR/GRHL1/EXT2/PLEC 8 GO:0010828 positive regulation of glucose transmembrane transport 7/998 46/18722 0.0103868621374157 0.0831745509500724 OPN3/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 7 GO:0055010 ventricular cardiac muscle tissue morphogenesis 7/998 46/18722 0.0103868621374157 0.0831745509500724 LRP2/DSP/TGFBR3/ISL1/TGFBR1/FGFR2/PKP2 7 GO:0060976 coronary vasculature development 7/998 46/18722 0.0103868621374157 0.0831745509500724 LRP2/ADAMTS6/NRP1/TGFBR3/TGFBR1/SETD2/GPC3 7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 7/998 46/18722 0.0103868621374157 0.0831745509500724 EGFR/ADAMTS1/MDM2/CCND1/EIF4G1/ANKRD17/RDX 7 GO:1900271 regulation of long-term synaptic potentiation 7/998 46/18722 0.0103868621374157 0.0831745509500724 APP/MME/PPP1R9A/NCSTN/EIF2AK4/GSK3B/NSG1 7 GO:0033273 response to vitamin 11/998 93/18722 0.0104692468142133 0.0833230756356821 EGFR/ATP2B1/BMP7/MDM2/FOLR1/DNMT3A/CCND1/TRIM24/STC2/ALAD/SRSF2 11 GO:0045185 maintenance of protein location 11/998 93/18722 0.0104692468142133 0.0833230756356821 FBN2/FBN1/HSPA5/GJA1/ANK3/SCIN/VPS13A/SUN1/GOPC/HNRNPU/KDELR1 11 GO:0060349 bone morphogenesis 11/998 93/18722 0.0104692468142133 0.0833230756356821 LRP5/GLG1/TRIP11/SERPINH1/TFAP2A/GLI3/MSX2/FGFR2/MMP14/EXT2/LTBP3 11 GO:1901992 positive regulation of mitotic cell cycle phase transition 11/998 93/18722 0.0104692468142133 0.0833230756356821 EGFR/APP/BRD4/PBX1/ADAMTS1/MDM2/CCND1/EIF4G1/ANKRD17/RDX/ANAPC5 11 GO:0061351 neural precursor cell proliferation 15/998 145/18722 0.0105967571215696 0.0842095417529911 LRP2/SPINT1/ADGRG1/SLC6A4/SPINT2/NF1/RERE/GLI3/SLC16A2/RYK/FZD6/FGFR2/PCM1/CTNNB1/CTNNA1 15 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 18/998 186/18722 0.0106395180484293 0.0844208567338136 WLS/TFRC/GJA1/BRD4/TGM2/TMED4/TLR3/SLC44A2/NDFIP2/ANKRD17/ZDHHC17/CTNNB1/DHX36/DDX1/PLK2/TAB3/TFG/SHISA5 18 GO:0031060 regulation of histone methylation 9/998 69/18722 0.0107233043688197 0.084914969485355 BRD4/DNMT1/ATRX/NSD1/PAXBP1/RIF1/CTNNB1/GATA3/LMNA 9 GO:0014032 neural crest cell development 10/998 81/18722 0.0107343190692079 0.084914969485355 NRP2/SEMA6A/SEMA6D/NRP1/LAMA5/BMP7/FOLR1/ISL1/SEMA3F/SEMA4B 10 GO:0046822 regulation of nucleocytoplasmic transport 12/998 106/18722 0.0107807538304468 0.0850055857342354 CDH1/PTPN14/MDM2/FERMT1/GLI3/TPR/NEDD4/SETD2/MAPK14/TCF7L2/UBR5/GSK3B 12 GO:0007569 cell aging 14/998 132/18722 0.0107946185293618 0.0850055857342354 MME/CDK6/CALR/PRKDC/TP63/PAWR/PLA2R1/KRAS/MAPK14/BCL2/PLK2/PDCD4/LMNA/YPEL3 14 GO:0035264 multicellular organism growth 14/998 132/18722 0.0107946185293618 0.0850055857342354 APP/ADRB1/ZFX/ATRX/EZR/AFG3L2/ARID5B/PLEKHA1/TNKS2/PPP1R13L/BCL2/PLEC/NIPBL/PPIB 14 GO:0070997 neuron death 30/998 361/18722 0.0109148916060614 0.0850420844575322 APP/NRP1/RASA1/SERPINF1/HSPA5/NF1/LRP1/ARL6IP5/PARP1/USP53/TFAP2A/HSPD1/ERBB3/ISL1/CLN3/SIAH1/SLC9A1/TP63/DHCR24/EIF4G1/NCSTN/PRKCI/KRAS/CTNNB1/GATA3/BCL2/GSK3B/OXR1/VPS35/TMEM259 30 GO:0032200 telomere organization 16/998 159/18722 0.0109165106755365 0.0850420844575322 PARP1/PRKDC/RAD50/ATRX/MAP3K4/DCP2/PKIB/HSP90AA1/RIF1/CTNNB1/DHX36/TNKS2/YLPM1/PPP1R10/HNRNPU/HNRNPA2B1 16 GO:0042953 lipoprotein transport 4/998 17/18722 0.0109377725239781 0.0850420844575322 LRP1/MIA3/PPARG/ZDHHC17 4 GO:0046827 positive regulation of protein export from nucleus 4/998 17/18722 0.0109377725239781 0.0850420844575322 MDM2/TPR/TCF7L2/GSK3B 4 GO:0061450 trophoblast cell migration 4/998 17/18722 0.0109377725239781 0.0850420844575322 ITGB4/GJA1/CALR/AGO2 4 GO:0090136 epithelial cell-cell adhesion 4/998 17/18722 0.0109377725239781 0.0850420844575322 DSP/ITGB5/KIFC3/CTNNA1 4 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 4/998 17/18722 0.0109377725239781 0.0850420844575322 CD24/YAP1/CTNNB1/GATA3 4 GO:2000811 negative regulation of anoikis 4/998 17/18722 0.0109377725239781 0.0850420844575322 ITGB1/PTK2/BCL2/TLE1 4 GO:0002026 regulation of the force of heart contraction 5/998 26/18722 0.010994714998819 0.0850420844575322 ADRB1/ATP2B4/SLC9A1/GAA/ATP2A2 5 GO:0046697 decidualization 5/998 26/18722 0.010994714998819 0.0850420844575322 GJA1/CTSV/ASH1L/BSG/STC2 5 GO:0051016 barbed-end actin filament capping 5/998 26/18722 0.010994714998819 0.0850420844575322 SCIN/TRIOBP/RDX/EPS8/ADD3 5 GO:0060037 pharyngeal system development 5/998 26/18722 0.010994714998819 0.0850420844575322 BMP7/FOLR1/ISL1/TGFBR1/GATA3 5 GO:0051099 positive regulation of binding 17/998 173/18722 0.0111128928616191 0.0858290142463216 APP/MET/NRP1/LRP1/PARP1/ISL1/EIF4G1/FMR1/PPARG/CTNNB1/TCF7L2/GATA3/PLK2/AKTIP/SPPL3/GSK3B/ANXA2 17 GO:0006403 RNA localization 19/998 201/18722 0.0112149207303676 0.0863615060962377 IGF2BP3/NCBP3/TPR/LRPPRC/DCP2/FMR1/SETD2/DHX36/MYO1C/RANBP17/RANBP2/ATXN2/QKI/YY1/AGFG1/PABPN1/HNRNPU/HNRNPA2B1/TOMM20 19 GO:0051054 positive regulation of DNA metabolic process 19/998 201/18722 0.0112149207303676 0.0863615060962377 EGFR/TFRC/PARP1/FUS/PRKDC/RAD50/ATRX/MAP3K4/USP9X/PKIB/HSP90AA1/RIF1/CTNNB1/DHX36/TNKS2/OTUD4/PPP1R10/ANXA3/HNRNPA2B1 19 GO:0048813 dendrite morphogenesis 15/998 146/18722 0.0112476887427443 0.0864862782413375 NRP1/ITGB1/CUX1/RERE/PPP1R9A/OBSL1/EFNA1/CDKL5/TPBG/NEDD4/KIDINS220/TMEM106B/DHX36/RBFOX2/GSK3B 15 GO:0048704 embryonic skeletal system morphogenesis 11/998 94/18722 0.0113036212170617 0.0867885387857046 BMP7/DLG1/TFAP2A/GLI3/TGFBR1/SETD2/SLC39A1/FGFR2/CTNNB1/MMP14/NIPBL 11 GO:0018208 peptidyl-proline modification 8/998 58/18722 0.0113916419125317 0.0873359213294095 P4HB/NKTR/PRDX4/FKBP14/RANBP2/P3H2/P3H1/PPIB 8 GO:0016197 endosomal transport 21/998 230/18722 0.0115555453594644 0.0883497254103436 TINAGL1/RHOBTB3/CLTC/EEA1/ABCA1/SPAG9/ERC1/TMEM87A/LEPROT/RAB6A/KIAA1109/CMTM6/VCP/GCC2/RAB11FIP4/ZFYVE16/SNX4/EVI5/ARL1/VPS35/NSG1 21 GO:0005976 polysaccharide metabolic process 12/998 107/18722 0.0115726073114491 0.0883497254103436 AGL/CLTC/IL6ST/PHKB/UGP2/B3GNT3/SORBS1/B3GNT2/GAA/EXT2/GSK3B/PHLDA2 12 GO:0007052 mitotic spindle organization 13/998 120/18722 0.0116159667757327 0.0883497254103436 CLTC/DYNC1H1/TACC2/TPR/VCP/GNAI1/GOLGA2/PLK2/MAP4/HSPA1B/STAG1/GPSM2/HNRNPU 13 GO:0071901 negative regulation of protein serine/threonine kinase activity 13/998 120/18722 0.0116159667757327 0.0883497254103436 BMP7/NR2F2/NF1/LRP5/PKIB/LATS2/PTPN1/PPARG/PIK3CB/CDKN1C/IPO7/PDCD4/HEXIM1 13 GO:0007162 negative regulation of cell adhesion 26/998 303/18722 0.0116381412865271 0.0883497254103436 CDH1/SEMA6A/KANK1/FBLN1/RASA1/DLG5/SPINT2/DLG1/LRP1/GCNT2/TACSTD2/ERBB3/GLI3/PLXNB1/PAWR/ACTN4/SWAP70/MIA3/JAM3/MMP14/RDX/PLXNA1/PTK2/ASS1/PHLDB2/CD164 26 GO:0014911 positive regulation of smooth muscle cell migration 7/998 47/18722 0.0116581149938118 0.0883497254103436 SEMA6D/NRP1/ADAMTS1/LRP1/FOXO4/MDM2/BCL2 7 GO:0045332 phospholipid translocation 7/998 47/18722 0.0116581149938118 0.0883497254103436 ATP10D/ANO6/KCNN4/ABCA1/TMEM30B/ABCB1/TMEM30A 7 GO:0043242 negative regulation of protein-containing complex disassembly 10/998 82/18722 0.0116592531713708 0.0883497254103436 LIMA1/SCIN/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 10 GO:0043087 regulation of GTPase activity 29/998 348/18722 0.0117548505188918 0.0889450355929477 ITGA6/MET/RASA1/ADRB1/ITGB1/NF1/AMOT/TGM2/DOCK9/IQGAP2/NET1/VAV3/DVL3/PLXNB1/CDKL5/CCDC125/SYDE2/FERMT2/DOCK8/SNX13/CHN2/RDX/PLXNA1/NEDD9/PTK2/ARFGEF1/GSK3B/GAPVD1/EVI5 29 GO:0009913 epidermal cell differentiation 19/998 202/18722 0.0117824418478187 0.089024788549148 DSP/NCOA3/EXPH5/YAP1/OPN3/MCOLN3/MYO7A/TP63/ESRP1/TRIOBP/IRF6/ERRFI1/GRHL1/CTNNB1/ST14/SGPP1/PLEC/MYO6/HDAC2 19 GO:0006942 regulation of striated muscle contraction 11/998 95/18722 0.0121878537925887 0.0919548911143142 DSP/DSC2/AKAP9/DLG1/GJA5/DSG2/DMD/SLC9A1/P2RX4/PKP2/ATP2A2 11 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 14/998 134/18722 0.0122250236725956 0.0919695224706362 GNA12/MDM2/RNF217/HECTD1/RAD23B/UFL1/BCAP31/VCP/SMARCC1/PLK2/HSPA1B/GSK3B/NFE2L2/USP14 14 GO:0061041 regulation of wound healing 14/998 134/18722 0.0122250236725956 0.0919695224706362 KANK1/ITGB1/GJA1/CLDN4/ANO6/PLPP3/FERMT1/FERMT2/PTK2/ARFGEF1/OCLN/PHLDB2/NFE2L2/ANXA2 14 GO:0043244 regulation of protein-containing complex disassembly 13/998 121/18722 0.012400340775469 0.0928773320927095 IGF1R/LIMA1/SCIN/CLN3/SWAP70/CAMSAP2/TRIOBP/UVRAG/RDX/EPS8/SPTAN1/SPTBN1/ADD3 13 GO:0048706 embryonic skeletal system development 13/998 121/18722 0.012400340775469 0.0928773320927095 BMP7/KIAA1217/PBX1/DLG1/TFAP2A/GLI3/TGFBR1/SETD2/SLC39A1/FGFR2/CTNNB1/MMP14/NIPBL 13 GO:0046578 regulation of Ras protein signal transduction 18/998 189/18722 0.0124121191261823 0.0928773320927095 MET/ADGRG1/KANK1/NRP1/RASA1/ITGB1/NET1/ABCA1/DENND4C/CCDC125/CYTH3/PIK3CB/KRAS/ARFGEF3/RDX/EPS8/ARFGEF1/OPHN1 18 GO:0051402 neuron apoptotic process 22/998 246/18722 0.0124168507566963 0.0928773320927095 APP/NRP1/RASA1/HSPA5/NF1/LRP1/PARP1/USP53/TFAP2A/HSPD1/ERBB3/ISL1/CLN3/SIAH1/TP63/NCSTN/PRKCI/KRAS/CTNNB1/GATA3/BCL2/OXR1 22 GO:0048678 response to axon injury 10/998 83/18722 0.0126431505310429 0.0943011237452641 DAG1/LRP1/MTR/FOLR1/ISL1/NREP/P2RX4/JAM3/BCL2/CTNNA1 10 GO:0050905 neuromuscular process 15/998 148/18722 0.0126433224711137 0.0943011237452641 APP/TMEM150C/HEXB/DMD/IGDCC3/MYO7A/CLN3/HOMER1/MYCBP2/SLC1A3/GM2A/GAA/ALDH1A3/ATP2A2/RBFOX2 15 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 6/998 37/18722 0.0127304464666066 0.0948154935836707 MAP3K4/PKIB/CTNNB1/DHX36/TNKS2/HNRNPA2B1 6 GO:0003208 cardiac ventricle morphogenesis 9/998 71/18722 0.0128287750173489 0.0954117298654969 LRP2/DSP/TGFBR3/ISL1/TGFBR1/FGFR2/PKP2/PPP1R13L/GATA3 9 GO:0018126 protein hydroxylation 5/998 27/18722 0.0129145635526648 0.0959131384188665 ASPH/P4HB/PRDX4/P3H2/P3H1 5 GO:0061647 histone H3-K9 modification 7/998 48/18722 0.013038072899043 0.0966928673379308 DNMT1/ZNF451/ASH1L/ATRX/RIF1/GATA3/LMNA 7 GO:0044264 cellular polysaccharide metabolic process 11/998 96/18722 0.0131237482090228 0.0971901977295152 AGL/IL6ST/PHKB/UGP2/B3GNT3/SORBS1/B3GNT2/GAA/EXT2/GSK3B/PHLDA2 11 GO:0031667 response to nutrient levels 37/998 474/18722 0.013233167701733 0.0977557015965237 EGFR/AGL/SLC2A1/ATP2B1/BMP7/SLC6A4/ADRB1/HSPA5/FOXO4/CTSV/EIF2AK1/MDM2/FOLR1/ABCA1/DNMT3A/SLC16A1/CCND1/STK26/GABARAPL1/EIF4G1/PPARG/EIF2AK4/TRIM24/SLC38A2/BCL2/ASS1/PLEC/STC2/ACSL3/TNRC6A/TTPA/PMAIP1/ALAD/NFE2L2/PAGE4/SRSF2/KRT18 37 GO:0022411 cellular component disassembly 35/998 443/18722 0.0132375562207895 0.0977557015965237 LAMC1/DPP4/IGF1R/LRP1/LIMA1/CTSV/SCIN/HUWE1/CLN3/UFL1/GABARAPL1/MMP15/DICER1/TGFBR1/SWAP70/CAMSAP2/TRIOBP/UVRAG/BLCAP/VCP/FZD5/DENR/MMP14/RDX/DDR1/EPS8/SMARCC1/SPTAN1/GOLGA2/SPTBN1/ATP2A2/ADD3/SNX14/GSK3B/MICAL3 35 GO:0097191 extrinsic apoptotic signaling pathway 20/998 219/18722 0.0134573249273486 0.0982805427534513 ITGA6/NRP1/ITGAV/IFI6/PDIA3/YAP1/ERBB3/TLR3/SIAH2/BIRC6/TGFBR1/TCF7L2/BCL2/SGPP1/HSPA1B/GSK3B/PMAIP1/CTNNA1/LMNA/KRT18 20 GO:0032785 negative regulation of DNA-templated transcription, elongation 4/998 18/18722 0.0134802725569143 0.0982805427534513 TCERG1/NELFCD/HEXIM1/HNRNPU 4 GO:0044872 lipoprotein localization 4/998 18/18722 0.0134802725569143 0.0982805427534513 LRP1/MIA3/PPARG/ZDHHC17 4 GO:0099558 maintenance of synapse structure 4/998 18/18722 0.0134802725569143 0.0982805427534513 DLG1/ERC1/SDF4/OPHN1 4 GO:0010632 regulation of epithelial cell migration 25/998 292/18722 0.0135200542016332 0.0982805427534513 MET/NRP2/NRP1/SERPINF1/NR2F2/NF1/CALR/PLPP3/ATP2B4/TACSTD2/EFNA1/MACF1/MARVELD3/RTN4/P2RX4/PPARG/PIK3CB/PTPRM/DOCK1/PTK2/GATA3/PLK2/EMC10/ANXA3/NFE2L2 25 GO:0033002 muscle cell proliferation 22/998 248/18722 0.0135419043002169 0.0982805427534513 EGFR/GJA1/ADAMTS1/TGM2/DNMT1/TGFBR3/YAP1/PRKDC/GNA12/SKP2/MDM2/SF1/S1PR2/TGFBR1/PPARG/PAXBP1/MAPK14/FGFR2/VGLL4/CTNNB1/TCF7L2/PDCD4 22 GO:0010976 positive regulation of neuron projection development 16/998 163/18722 0.0136242082773884 0.0982805427534513 ITGA6/TENM3/BMP7/SERPINF1/HSPA5/LRP1/PPP1R9A/COBL/CREB3L2/PRKCI/KIDINS220/TMEM106B/DHX36/TMEM30A/P3H1/NFE2L2 16 GO:0036293 response to decreased oxygen levels 27/998 322/18722 0.0136275935201164 0.0982805427534513 SLC2A1/HSP90B1/BMP7/SLC6A4/DPP4/P4HB/NF1/CD24/TGFBR3/HSPD1/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/TM9SF4/MALAT1/MMP14/BCL2/STC2/SOD3/HILPDA/PMAIP1/ALAD/LMNA/SLC29A1/NFE2L2 27 GO:0021932 hindbrain radial glia guided cell migration 3/998 10/18722 0.0136662850103439 0.0982805427534513 ITGB1/RERE/RBFOX2 3 GO:0030953 astral microtubule organization 3/998 10/18722 0.0136662850103439 0.0982805427534513 DLG1/LIMK2/EZR 3 GO:0036363 transforming growth factor beta activation 3/998 10/18722 0.0136662850103439 0.0982805427534513 ITGAV/ITGB8/LTBP3 3 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence 3/998 10/18722 0.0136662850103439 0.0982805427534513 EMC1/EMC10/EMC7 3 GO:0051660 establishment of centrosome localization 3/998 10/18722 0.0136662850103439 0.0982805427534513 DLG1/EZR/PARD3 3 GO:0072178 nephric duct morphogenesis 3/998 10/18722 0.0136662850103439 0.0982805427534513 AHI1/GATA3/GPC3 3 GO:1902946 protein localization to early endosome 3/998 10/18722 0.0136662850103439 0.0982805427534513 NRP1/EZR/RDX 3 GO:1903867 extraembryonic membrane development 3/998 10/18722 0.0136662850103439 0.0982805427534513 BMP7/MAP3K4/FZD5 3 GO:1904350 regulation of protein catabolic process in the vacuole 3/998 10/18722 0.0136662850103439 0.0982805427534513 LRP2/LRP1/RNF128 3 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 3/998 10/18722 0.0136662850103439 0.0982805427534513 ATP2B4/DMD/OXR1 3 GO:2000288 positive regulation of myoblast proliferation 3/998 10/18722 0.0136662850103439 0.0982805427534513 PAXBP1/MALAT1/MEIS2 3 GO:0006835 dicarboxylic acid transport 10/998 84/18722 0.0136882144993081 0.0983028444303818 LRP2/SLC26A2/ITGB1/GJA1/ARL6IP5/SLC19A1/SLC13A3/FOLR1/SLC1A5/SLC1A3 10 GO:0043401 steroid hormone mediated signaling pathway 14/998 136/18722 0.0137984619847872 0.0989584753057333 BMP7/PARP1/CALR/YAP1/SKP2/ISL1/ESRRG/DDX17/TP63/UFL1/NEDD4/UBR5/RBFOX2/TMF1 14 GO:0030330 DNA damage response, signal transduction by p53 class mediator 9/998 72/18722 0.0139898350807774 0.100193318184827 PTTG1IP/MDM2/ATRX/USP10/SMYD2/PLA2R1/PLK2/MYO6/PMAIP1 9 GO:0070252 actin-mediated cell contraction 11/998 97/18722 0.0141131074160217 0.100937717560342 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/SLC9A1/PKP2/ATP2A2/GPD1L 11 GO:0009408 response to heat 12/998 110/18722 0.014218097214525 0.101549501446012 HSPD1/TPR/RBBP7/DNAJB4/HSP90AA1/VCP/DHX36/SLC52A3/ATP2A2/HSPA1B/GSK3B/HDAC2 12 GO:0042692 muscle cell differentiation 31/998 384/18722 0.0143532304472068 0.102374612247086 ITGB1/DNMT1/ERVW-1/CALR/FOXO4/MYOF/MDM2/DMD/ISL1/OBSL1/SPAG9/SLC9A1/KLF5/HOMER1/AFG3L2/ANKRD17/ACTN4/KRAS/MAPK14/FGFR2/CTNNB1/BHLHE41/MMP14/BCL2/ATP2A2/PLEC/PDCD4/QKI/YY1/LMNA/HNRNPU 31 GO:0097242 amyloid-beta clearance 6/998 38/18722 0.0144538056902393 0.102951322658581 LRP2/MME/LRPAP1/IGF1R/LRP1/CLTC 6 GO:0009409 response to cold 7/998 49/18722 0.0145314736939268 0.103162042469287 ATP2B1/ADRB1/HSPD1/ACADVL/SLC9A1/HSP90AA1/EIF2AK4 7 GO:0045778 positive regulation of ossification 7/998 49/18722 0.0145314736939268 0.103162042469287 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/NIPBL/ATRAID 7 GO:0006979 response to oxidative stress 35/998 446/18722 0.0145426667798114 0.103162042469287 EGFR/APP/MET/BMP7/P4HB/ARL6IP5/PARP1/IDH1/FUT8/PON2/NET1/HSPD1/MDM2/PRDX4/SFPQ/STK26/DHCR24/PAWR/NFE2L1/PLA2R1/GPX8/TRA2B/PLEKHA1/CTNNB1/MMP14/BCL2/ATP2A2/HSPA1B/SOD3/CHD6/ALAD/OXR1/HDAC2/NFE2L2/PAGE4 35 GO:0007266 Rho protein signal transduction 14/998 137/18722 0.0146415755387234 0.10358220309983 MET/ADGRG1/KANK1/NRP1/ITGB1/HACD3/GNA12/NET1/ABCA1/ARHGAP5/CCDC125/CTNNAL1/EPS8/OPHN1 14 GO:0030879 mammary gland development 14/998 137/18722 0.0146415755387234 0.10358220309983 LRP5/PRLR/ARHGAP5/GLI3/KDM5B/CCND1/RTN4/CDO1/IRF6/FGFR2/DDR1/GATA3/FASN/SLC29A1 14 GO:0060021 roof of mouth development 10/998 85/18722 0.0147966394657565 0.104537557037503 ITGB8/DLG1/TGFBR3/FRAS1/TFAP2A/GLI3/TGFBR1/IRF6/ARID5B/PLEKHA1 10 GO:0071456 cellular response to hypoxia 15/998 151/18722 0.0149855692127738 0.105729266026881 BMP7/P4HB/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/MALAT1/BCL2/STC2/HILPDA/PMAIP1/LMNA/SLC29A1/NFE2L2 15 GO:0006516 glycoprotein catabolic process 5/998 28/18722 0.0150485898459188 0.106030617524348 CTSL/MANBA/STT3B/EDEM3/GPC1 5 GO:0000209 protein polyubiquitination 21/998 236/18722 0.0151041616216181 0.10613570366954 SKP2/MDM2/UBE2H/NHLRC3/RNF217/HECTD1/TRIM44/HUWE1/KLHL42/UBE4B/NEDD4/NPEPPS/CTNNB1/WWP1/TNKS2/BCL2/ANAPC5/AKTIP/UBR5/TTC3/UBE2G2 21 GO:0090068 positive regulation of cell cycle process 21/998 236/18722 0.0151041616216181 0.10613570366954 EGFR/APP/BRD4/PBX1/LRP5/ADAMTS1/DYNC1H1/MDM2/ATRX/TPR/CCND1/SFPQ/EIF4G1/ANKRD17/PKN2/RAD21/RDX/ANAPC5/GPSM2/PPP1R10/HNRNPU 21 GO:0043502 regulation of muscle adaptation 11/998 98/18722 0.0151577303065413 0.106368964960285 DAG1/PARP1/ATP2B4/IL6ST/CAMK2G/SLC9A1/P2RX4/ERRFI1/ATP2A2/YY1/LMNA 11 GO:0040014 regulation of multicellular organism growth 8/998 61/18722 0.0152282566395252 0.106577383264023 APP/ADRB1/EZR/AFG3L2/TNKS2/BCL2/NIPBL/PPIB 8 GO:0060998 regulation of dendritic spine development 8/998 61/18722 0.0152282566395252 0.106577383264023 DLG5/PPP1R9A/EFNA1/CDKL5/FMR1/DHX36/PLK2/HDAC2 8 GO:0031334 positive regulation of protein-containing complex assembly 21/998 237/18722 0.0157712683426076 0.110229975926043 MET/CLIP1/TFRC/AKAP9/DLG1/IQGAP2/MPP7/SCIN/ABCA1/FERMT1/WASF2/FERMT2/EIF4G1/ICE1/HSP90AA1/VCP/MYO1C/NCKAP1/OCLN/HSPA1B/GSK3B 21 GO:0008643 carbohydrate transport 15/998 152/18722 0.0158365205766407 0.110538066752194 SLC2A1/SLC5A3/SLC35B4/OPN3/YES1/EZR/PRKCI/SLC35D1/SORBS1/MAPK14/SLC17A5/OCLN/SLC45A4/GPC3/NFE2L2 15 GO:0006493 protein O-linked glycosylation 10/998 86/18722 0.0159706060374828 0.11096370069879 GALNT11/C1GALT1/GXYLT1/TET2/B3GNT3/TMTC3/B3GNT2/GCNT4/GALNT18/B4GAT1 10 GO:0035023 regulation of Rho protein signal transduction 10/998 86/18722 0.0159706060374828 0.11096370069879 MET/ADGRG1/KANK1/NRP1/ITGB1/NET1/ABCA1/CCDC125/EPS8/OPHN1 10 GO:1903510 mucopolysaccharide metabolic process 10/998 86/18722 0.0159706060374828 0.11096370069879 ITIH5/CLTC/CHPF/B3GNT3/GLCE/B3GNT2/EXT2/GNS/B4GAT1/GLB1 10 GO:0007033 vacuole organization 17/998 180/18722 0.0159825134888891 0.11096370069879 HEXB/ABCA1/SYT7/HOOK2/MYO7A/CLN3/MBTPS1/GABARAPL1/TMEM41B/TMEM106B/TMEM165/GNPTAB/GAA/MAN2A1/AKTIP/ATP2A2/ANXA2 17 GO:0045862 positive regulation of proteolysis 30/998 372/18722 0.0160325723729341 0.111163426771698 APP/FBLN1/ASPH/PERP/CLDN4/ARL6IP5/PCOLCE2/HSPD1/MDM2/LPCAT3/RNF217/HECTD1/EFNA1/NCSTN/FMR1/TMTC3/PPARG/BCAP31/VCP/NRDC/SH3D19/MMP14/PTK2/PLK2/HSPA1B/GSK3B/PMAIP1/HDAC2/NFE2L2/TMEM259 30 GO:0042391 regulation of membrane potential 34/998 434/18722 0.0162195473350956 0.112303854948073 DSP/APP/DSC2/ADRB1/AKAP9/GJA1/IFI6/GABRE/DLG1/GJA5/DSG2/ANK3/ARL6IP5/PARP1/USP53/KCNN4/DMD/PPP1R9A/SLC25A36/CLN3/SLC9A1/S1PR2/FMR1/NEDD4/P2RX4/GABRA4/VCP/PKP2/BCL2/ATP2A2/GSK3B/PMAIP1/GPD1L/SLC29A1 34 GO:0001933 negative regulation of protein phosphorylation 28/998 342/18722 0.0162880043523072 0.112303854948073 FBLN1/BMP7/NR2F2/NF1/LRP5/LRP1/PRKDC/CTDSPL/PLPP3/DMD/SPAG9/EIF4G1/PKIB/LATS2/SUZ12/PARD3/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/PLEC/OCLN/PDCD4/HEXIM1/GPD1L 28 GO:0010463 mesenchymal cell proliferation 6/998 39/18722 0.0163329171526661 0.112303854948073 BMP7/LRP5/FGFR2/CTNNB1/GPC3/LMNA 6 GO:0086091 regulation of heart rate by cardiac conduction 6/998 39/18722 0.0163329171526661 0.112303854948073 DSP/DSC2/AKAP9/DSG2/ISL1/PKP2 6 GO:0015802 basic amino acid transport 4/998 19/18722 0.0163691311272714 0.112303854948073 SLC38A9/SLC7A6/CLN3/SLC7A2 4 GO:0030011 maintenance of cell polarity 4/998 19/18722 0.0163691311272714 0.112303854948073 DST/DLG5/SLC9A1/GSK3B 4 GO:0044827 modulation by host of viral genome replication 4/998 19/18722 0.0163691311272714 0.112303854948073 FMR1/EIF2AK4/STOM/PPIB 4 GO:0060065 uterus development 4/998 19/18722 0.0163691311272714 0.112303854948073 ASH1L/KDM5B/GATA3/NIPBL 4 GO:0006635 fatty acid beta-oxidation 9/998 74/18722 0.0165422532474804 0.113342656437133 SLC27A2/HADHA/CROT/ECHDC2/ACADVL/ECI2/CPT2/ECHDC1/ETFA 9 GO:0007062 sister chromatid cohesion 8/998 62/18722 0.0166934487462409 0.114199898806059 ATRX/SFPQ/RAD21/CTNNB1/WAPL/PDS5A/NIPBL/STAG1 8 GO:0097305 response to alcohol 22/998 253/18722 0.0167111133284484 0.114199898806059 CDH1/ATP2B1/DAG1/PARP1/TGFBR3/GGH/MDM2/ABCA1/DNMT3A/CCND1/TGFBR1/CDO1/FGFR2/CTNNB1/GNAI1/EPS8/GATA3/SDF4/ALAD/CTNNA1/HDAC2/GLB1 22 GO:2001234 negative regulation of apoptotic signaling pathway 20/998 224/18722 0.0168495705302457 0.114995565671128 ITGA6/NRP1/ITGAV/IFI6/YAP1/PTTG1IP/MDM2/USP47/SIAH2/BIRC6/TGFBR1/PTPN1/CTNNB1/TCF7L2/BCL2/HSPA1B/GSK3B/CTNNA1/LMNA/NFE2L2 20 GO:0045787 positive regulation of cell cycle 26/998 313/18722 0.0170186681667657 0.115997998040057 EGFR/APP/SLC6A4/BRD4/PBX1/LRP5/ADAMTS1/CALR/DYNC1H1/MDM2/ATRX/TPR/CCND1/SFPQ/EIF4G1/ANKRD17/PKN2/RAD21/FGFR2/RDX/ANAPC5/USP22/MEIS2/GPSM2/PPP1R10/HNRNPU 26 GO:0044070 regulation of anion transport 10/998 87/18722 0.0172122762143038 0.116859940331444 TCAF1/ITGB1/GABRE/SLC43A2/ARL6IP5/PLA2R1/P2RX4/AHCYL1/GOPC/ABCB1 10 GO:1901879 regulation of protein depolymerization 10/998 87/18722 0.0172122762143038 0.116859940331444 LIMA1/SCIN/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3 10 GO:2000177 regulation of neural precursor cell proliferation 10/998 87/18722 0.0172122762143038 0.116859940331444 LRP2/SPINT1/ADGRG1/SLC6A4/SPINT2/NF1/GLI3/SLC16A2/CTNNB1/CTNNA1 10 GO:0031623 receptor internalization 12/998 113/18722 0.017300098160766 0.117134568867548 TFRC/ITGB1/LRPAP1/LRP1/CLTC/AHI1/EZR/FMR1/NEDD4/RAB31/ATXN2/OPHN1 12 GO:0009306 protein secretion 29/998 359/18722 0.0173183098349807 0.117134568867548 EGFR/MYH10/WLS/DPP4/GJA1/LRP5/FAM3B/LRP1/EXPH5/FRMD4A/CCDC186/CANX/KCNN4/CAMK2G/PDIA4/ABCA1/ISL1/SYT7/EXOC1/SLC16A1/CD2AP/ERP29/EZR/MIA3/GNPTAB/SEL1L/TCF7L2/RAB11FIP1/P3H1 29 GO:0006656 phosphatidylcholine biosynthetic process 5/998 29/18722 0.017406037832066 0.117134568867548 CDS1/LPCAT3/SLC44A1/SLC44A2/ACSL3 5 GO:0019082 viral protein processing 5/998 29/18722 0.017406037832066 0.117134568867548 FUT8/CANX/MOGS/MAN2A1/GSK3B 5 GO:0021602 cranial nerve morphogenesis 5/998 29/18722 0.017406037832066 0.117134568867548 NRP2/NRP1/TFAP2A/GLI3/SEMA3F 5 GO:0034067 protein localization to Golgi apparatus 5/998 29/18722 0.017406037832066 0.117134568867548 OBSL1/RAB6A/VPS13A/GCC2/ARL1 5 GO:0050768 negative regulation of neurogenesis 14/998 140/18722 0.0174097731164944 0.117134568867548 SEMA6A/SEMA6D/NRP1/BMP7/NF1/PRTG/RTN4/SEMA3F/DICER1/RYK/PCM1/CTNNB1/SEMA4B/CTNNA1 14 GO:0045664 regulation of neuron differentiation 18/998 196/18722 0.017456616515982 0.117298577644713 APP/BMP7/SLC6A4/PBX1/CALR/ISL1/GLI3/ZFHX3/NRCAM/SPAG9/EIF4G1/NREP/TUG1/ESRP1/EIF2AK4/BCL2/GSK3B/MAP3K13 18 GO:0051656 establishment of organelle localization 31/998 390/18722 0.0175002344016889 0.117440519037555 SYNE2/ITGB1/GJA1/DLG1/EML4/TRIP11/CCDC186/DYNC1H1/ARHGAP21/FNBP1L/LIMK2/MYO7A/CLN3/TMED9/LRPPRC/RAB6A/EZR/ACTN4/PARD3/PCM1/CTNNB1/SUN1/MYO1C/MAP4/GPSM2/MYO6/LSG1/SNX4/ARMCX3/TFG/HNRNPU 31 GO:0051168 nuclear export 15/998 154/18722 0.0176495318640618 0.118286187353055 CALR/PTPN14/MDM2/TPR/SETD2/AHCYL1/NEMF/RANBP17/TCF7L2/GSK3B/LSG1/AGFG1/PABPN1/HSPA9/HNRNPA2B1 15 GO:0060043 regulation of cardiac muscle cell proliferation 7/998 51/18722 0.017876962238055 0.118286187353055 GJA1/TGFBR3/YAP1/TGFBR1/MAPK14/FGFR2/VGLL4 7 GO:0035592 establishment of protein localization to extracellular region 29/998 360/18722 0.0179134954019912 0.118286187353055 EGFR/MYH10/WLS/DPP4/GJA1/LRP5/FAM3B/LRP1/EXPH5/FRMD4A/CCDC186/CANX/KCNN4/CAMK2G/PDIA4/ABCA1/ISL1/SYT7/EXOC1/SLC16A1/CD2AP/ERP29/EZR/MIA3/GNPTAB/SEL1L/TCF7L2/RAB11FIP1/P3H1 29 GO:0043627 response to estrogen 9/998 75/18722 0.0179389751639739 0.118286187353055 CD24/HSPD1/MDM2/GLI3/CCND1/TRIM24/MMP14/GATA3/CTNNA1 9 GO:0009313 oligosaccharide catabolic process 3/998 11/18722 0.0180567116108763 0.118286187353055 HEXB/MANBA/GM2A 3 GO:0021561 facial nerve development 3/998 11/18722 0.0180567116108763 0.118286187353055 NRP2/NRP1/SEMA3F 3 GO:0021604 cranial nerve structural organization 3/998 11/18722 0.0180567116108763 0.118286187353055 NRP2/NRP1/SEMA3F 3 GO:0021610 facial nerve morphogenesis 3/998 11/18722 0.0180567116108763 0.118286187353055 NRP2/NRP1/SEMA3F 3 GO:0032329 serine transport 3/998 11/18722 0.0180567116108763 0.118286187353055 SLC1A5/SLC38A2/SERINC3 3 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 3/998 11/18722 0.0180567116108763 0.118286187353055 PARP1/YAP1/SKP2 3 GO:0033197 response to vitamin E 3/998 11/18722 0.0180567116108763 0.118286187353055 CCND1/ALAD/SRSF2 3 GO:0035581 sequestering of extracellular ligand from receptor 3/998 11/18722 0.0180567116108763 0.118286187353055 FBN2/FBN1/CD46 3 GO:0060742 epithelial cell differentiation involved in prostate gland development 3/998 11/18722 0.0180567116108763 0.118286187353055 TP63/FGFR2/CTNNB1 3 GO:0071679 commissural neuron axon guidance 3/998 11/18722 0.0180567116108763 0.118286187353055 DAG1/NRP1/RYK 3 GO:0072497 mesenchymal stem cell differentiation 3/998 11/18722 0.0180567116108763 0.118286187353055 CTNNB1/LTBP3/KRT18 3 GO:0072697 protein localization to cell cortex 3/998 11/18722 0.0180567116108763 0.118286187353055 EZR/GNAI1/GPSM2 3 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 3/998 11/18722 0.0180567116108763 0.118286187353055 N4BP2L2/NFE2L2/HSPA9 3 GO:1903961 positive regulation of anion transmembrane transport 3/998 11/18722 0.0180567116108763 0.118286187353055 TCAF1/ITGB1/ABCB1 3 GO:2000644 regulation of receptor catabolic process 3/998 11/18722 0.0180567116108763 0.118286187353055 PTPN1/MYLIP/ANXA2 3 GO:0030501 positive regulation of bone mineralization 6/998 40/18722 0.0183739218319591 0.119988153903699 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ATRAID 6 GO:0002244 hematopoietic progenitor cell differentiation 12/998 114/18722 0.018431430651363 0.119988153903699 ZFAT/RBM47/PRKDC/PRRC2C/N4BP2L2/UFL1/JAM3/DHX36/GATA3/BCL2/NFE2L2/HSPA9 12 GO:0007041 lysosomal transport 12/998 114/18722 0.018431430651363 0.119988153903699 LRP1/HOOK2/CLN3/NEDD4/VCP/TMEM106B/GNPTAB/GCC2/HGSNAT/AKTIP/ZFYVE16/VPS35 12 GO:0046660 female sex differentiation 12/998 114/18722 0.018431430651363 0.119988153903699 LRP2/HSPA5/NR2F2/ADAMTS1/IDH1/ZFX/TP63/ARID5B/PLEKHA1/MMP14/BCL2/CTNNA1 12 GO:1901800 positive regulation of proteasomal protein catabolic process 12/998 114/18722 0.018431430651363 0.119988153903699 MDM2/RNF217/HECTD1/FMR1/TMTC3/BCAP31/VCP/PLK2/HSPA1B/GSK3B/NFE2L2/TMEM259 12 GO:0006665 sphingolipid metabolic process 15/998 155/18722 0.0186135256038889 0.121022686398386 DEGS1/ORMDL1/ITGB8/HACD3/PLPP3/HEXB/SERINC2/SPTLC3/HEXA/GM2A/SGPP1/SERINC3/SUMF1/TECR/GLB1 15 GO:0070482 response to oxygen levels 28/998 347/18722 0.0193562242336538 0.125695082989934 SLC2A1/HSP90B1/BMP7/SLC6A4/DPP4/P4HB/NF1/CD24/TGFBR3/HSPD1/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/TM9SF4/MALAT1/MMP14/BCL2/STC2/SOD3/HILPDA/PMAIP1/ALAD/HDAC2/LMNA/SLC29A1/NFE2L2 28 GO:0008652 cellular amino acid biosynthetic process 9/998 76/18722 0.0194195451809253 0.125793356562793 ATP2B4/MTR/CLN3/SLC1A3/AASDHPPT/ALDH18A1/ASS1/SERINC3/BCAT1 9 GO:0140115 export across plasma membrane 9/998 76/18722 0.0194195451809253 0.125793356562793 ATP2B1/GJA1/DLG1/SLC40A1/ANO6/ABCA1/SLC9A1/SLC22A5/ABCB1 9 GO:2000045 regulation of G1/S transition of mitotic cell cycle 14/998 142/18722 0.0194653343662099 0.125933718371725 EGFR/DLG1/ADAMTS1/PRKDC/CTDSPL/MDM2/CCND1/EIF4G1/ANKRD17/WEE1/BRD7/RDX/BCL2/PLK2 14 GO:0035051 cardiocyte differentiation 15/998 156/18722 0.0196171304200956 0.126135568903544 EGFR/BMP7/ITGB1/TGFBR3/CALR/FOLR1/ISL1/OBSL1/SLC9A1/DHX36/PLEC/PDCD4/YY1/LMNA/HNRNPU 15 GO:0030278 regulation of ossification 12/998 115/18722 0.0196172359480828 0.126135568903544 FBN2/ATP2B1/BMP7/PBX1/ANO6/TFAP2A/ANKH/MAPK14/BCL2/LTBP3/NIPBL/ATRAID 12 GO:1901989 positive regulation of cell cycle phase transition 12/998 115/18722 0.0196172359480828 0.126135568903544 EGFR/APP/BRD4/PBX1/ADAMTS1/MDM2/CCND1/EIF4G1/ANKRD17/RDX/ANAPC5/PPP1R10 12 GO:0007097 nuclear migration 4/998 20/18722 0.0196173303868374 0.126135568903544 SYNE2/DYNC1H1/PCM1/SUN1 4 GO:0043586 tongue development 4/998 20/18722 0.0196173303868374 0.126135568903544 EGFR/GLI3/CTNNB1/HDAC2 4 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 7/998 52/18722 0.0197378790052572 0.126331991814772 PLPP3/ERGIC3/RAB6A/ERGIC2/UVRAG/COPB2/KDELR1 7 GO:0034204 lipid translocation 7/998 52/18722 0.0197378790052572 0.126331991814772 ATP10D/ANO6/KCNN4/ABCA1/TMEM30B/ABCB1/TMEM30A 7 GO:0043090 amino acid import 7/998 52/18722 0.0197378790052572 0.126331991814772 ITGB1/SLC43A2/ARL6IP5/SLC16A2/SLC1A5/SLC7A2/SLC1A3 7 GO:0048872 homeostasis of number of cells 23/998 272/18722 0.0197446667919659 0.126331991814772 ADGRG1/LGR4/CDK6/TGFBR3/PRKDC/ZFX/RCOR1/LPCAT3/FSTL1/UFL1/NCSTN/PIK3CB/KRAS/JAM3/MAPK14/GCNT4/GATA3/BCL2/RBFOX2/HSPA1B/PMAIP1/HSPA9/OCIAD1 23 GO:0032507 maintenance of protein location in cell 8/998 64/18722 0.0199236813230399 0.127002472373331 HSPA5/GJA1/ANK3/SCIN/VPS13A/SUN1/HNRNPU/KDELR1 8 GO:0046825 regulation of protein export from nucleus 5/998 30/18722 0.0199954093642747 0.127002472373331 PTPN14/MDM2/TPR/TCF7L2/GSK3B 5 GO:0060218 hematopoietic stem cell differentiation 5/998 30/18722 0.0199954093642747 0.127002472373331 PRKDC/N4BP2L2/UFL1/NFE2L2/HSPA9 5 GO:0061384 heart trabecula morphogenesis 5/998 30/18722 0.0199954093642747 0.127002472373331 BMP7/ADAMTS1/TGFBR3/TGFBR1/ADGRG6 5 GO:2000637 positive regulation of gene silencing by miRNA 5/998 30/18722 0.0199954093642747 0.127002472373331 EGFR/PUM1/EIF4G1/FMR1/AGO2 5 GO:2000648 positive regulation of stem cell proliferation 5/998 30/18722 0.0199954093642747 0.127002472373331 GJA1/N4BP2L2/FERMT2/LTBP3/HNRNPU 5 GO:0097193 intrinsic apoptotic signaling pathway 24/998 288/18722 0.0205243674601345 0.130203794057548 PERP/P4HB/IFI6/ARL6IP5/PARP1/CD24/PRKDC/PTTG1IP/MDM2/USP47/SIAH1/TP63/SFPQ/ERP29/BCLAF1/PTPN1/BCAP31/BCL2/SGPP1/SERINC3/PMAIP1/CUL5/SHISA5/NFE2L2 24 GO:0031062 positive regulation of histone methylation 6/998 41/18722 0.0205826405544387 0.130256928890575 BRD4/DNMT1/PAXBP1/RIF1/CTNNB1/LMNA 6 GO:0071634 regulation of transforming growth factor beta production 6/998 41/18722 0.0205826405544387 0.130256928890575 CD46/ITGAV/ITGB8/CD24/FERMT1/CD2AP 6 GO:0007034 vacuolar transport 15/998 157/18722 0.0206613062129672 0.130596464573731 LRP1/HOOK2/CLN3/LEPROT/NDFIP2/VPS13A/NEDD4/VCP/TMEM106B/GNPTAB/GCC2/HGSNAT/AKTIP/ZFYVE16/VPS35 15 GO:0030518 intracellular steroid hormone receptor signaling pathway 12/998 116/18722 0.0208589799776005 0.131686498746133 PARP1/CALR/YAP1/SKP2/ISL1/DDX17/TP63/UFL1/NEDD4/UBR5/RBFOX2/TMF1 12 GO:0045927 positive regulation of growth 22/998 259/18722 0.0212536207834827 0.133647872304493 EGFR/NRP1/GOLGA4/LRP1/TGFBR3/YAP1/PRKDC/TFCP2L1/USP47/CDKL5/SLC9A1/MACF1/EIF4G1/EZR/TGFBR1/MAPK14/FGFR2/MMP14/BCL2/NIPBL/MAP3K13/PPIB 22 GO:0002027 regulation of heart rate 11/998 103/18722 0.021272051692211 0.133647872304493 DSP/DSC2/ADRB1/AKAP9/DSG2/MDM2/DMD/ISL1/PKP2/ATP2A2/GPD1L 11 GO:0014013 regulation of gliogenesis 11/998 103/18722 0.021272051692211 0.133647872304493 EGFR/LRP2/SPINT1/DAG1/NF1/IL6ST/UFL1/PRKCI/DICER1/CTNNB1/HDAC2 11 GO:0019395 fatty acid oxidation 11/998 103/18722 0.021272051692211 0.133647872304493 SLC27A2/HADHA/CROT/ECHDC2/ACADVL/ECI2/CPT2/MAPK14/ADH5/ECHDC1/ETFA 11 GO:0031345 negative regulation of cell projection organization 17/998 186/18722 0.021351584599293 0.133747423917637 SEMA6A/SEMA6D/KANK1/NRP1/LRP1/YAP1/MDM2/TACSTD2/EFNA1/LIMK2/RTN4/SEMA3F/RYK/SEMA4B/MYLIP/MAP4/HDAC2 17 GO:0034109 homotypic cell-cell adhesion 10/998 90/18722 0.0213647484289042 0.133747423917637 DSP/DSC2/DSG2/ANK3/PLPP3/IL6ST/PIK3CB/PKP2/RDX/GNAS 10 GO:0046849 bone remodeling 10/998 90/18722 0.0213647484289042 0.133747423917637 EGFR/TFRC/GJA1/LGR4/NF1/LRP5/SUCO/SYT7/CTNNB1/LTBP3 10 GO:0051028 mRNA transport 13/998 130/18722 0.0214242480108169 0.133959280077215 IGF2BP3/NCBP3/TPR/LRPPRC/FMR1/SETD2/MYO1C/RANBP17/RANBP2/QKI/AGFG1/PABPN1/HNRNPA2B1 13 GO:0042770 signal transduction in response to DNA damage 16/998 172/18722 0.021617833953257 0.135008027595639 FOXO4/PRKDC/PTTG1IP/MDM2/ATRX/CCND1/USP10/SMYD2/PLA2R1/EIF2AK4/MAPK14/PLK2/MYO6/PMAIP1/XPC/PPP1R10 16 GO:0048645 animal organ formation 8/998 65/18722 0.0216952256726266 0.135167987156066 LRP2/BMP7/FOLR1/ISL1/GLI3/TP63/FGFR2/CTNNB1 8 GO:1905330 regulation of morphogenesis of an epithelium 8/998 65/18722 0.0216952256726266 0.135167987156066 MAGED1/BMP7/GJA1/LGR4/TACSTD2/CTNNB1/GATA3/BTBD7 8 GO:0032784 regulation of DNA-templated transcription, elongation 7/998 53/18722 0.0217298629732868 0.135222425010167 BRD4/CTNNB1/TCERG1/NELFCD/ELL/HEXIM1/HNRNPU 7 GO:0009416 response to light stimulus 26/998 320/18722 0.0218389529275396 0.135739491946053 EGFR/APP/MME/ITGB1/DDB1/NF1/PARP1/OPN3/MDM2/CDS1/USP47/MAP3K4/CCND1/UBE4B/FMR1/NEDD4/SLC1A3/KRAS/EIF2AK4/DHX36/NR2F6/BCL2/SDF4/MEIS2/XPC/YY1 26 GO:0045861 negative regulation of proteolysis 28/998 351/18722 0.0221252125233095 0.137355213536503 ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/IFI6/GLG1/LRP1/SERPINH1/MDM2/USP25/USP47/EFNA1/CLN3/SIAH2/DHCR24/BIRC6/TMEM59/CAST/SMARCC1/OPHN1/GPC3/ALAD/USP14/PEBP1/ANXA2 28 GO:0009612 response to mechanical stimulus 19/998 216/18722 0.0223764914071363 0.138750191967528 EGFR/SLC2A1/DAG1/GJA1/USP53/TMEM150C/DMD/TLR3/SLC9A1/SLC1A3/MAPK14/CTNNB1/SUN1/SLC38A2/MMP14/PTK2/PLEC/MEIS2/XPC 19 GO:0006869 lipid transport 31/998 398/18722 0.0225267575957569 0.139516253152368 SLC2A1/ITGAV/SLC27A2/ATP10D/ANO6/LRP1/LIMA1/KCNN4/ABCA1/LPCAT3/SYT7/CROT/KDM5B/PLEKHA8/CLN3/OSBPL9/PLA2R1/P2RX4/PPARG/CPT2/TMEM30B/GM2A/HDLBP/ESYT2/ABCB1/SGPP1/TMEM30A/ACSL3/TTPA/TMF1/ANXA2 31 GO:0034637 cellular carbohydrate biosynthetic process 9/998 78/18722 0.022642439156142 0.13976181275308 AGL/ISYNA1/B4GALT1/UGP2/B3GNT3/SORBS1/B3GNT2/EXT2/GSK3B 9 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/998 131/18722 0.0226684951214021 0.13976181275308 FBN2/FBN1/LRP2/PEG10/CRIM1/HSPA5/GLG1/LRP1/TGFBR3/ZNF451/TRIM33/PPARG/EID2 13 GO:0032963 collagen metabolic process 11/998 104/18722 0.0226853803177246 0.13976181275308 CTSL/ITGB1/SUCO/SERPINH1/MMP15/TRAM2/ERRFI1/MMP14/P3H2/P3H1/HDAC2 11 GO:0052547 regulation of peptidase activity 35/998 461/18722 0.0227137927852472 0.13976181275308 ITIH5/APP/SPINT1/APLP2/CRIM1/FBLN1/ASPH/SERPINF1/PERP/SPINT2/IFI6/CLDN4/LRP1/ARL6IP5/PCOLCE2/SERPINH1/HSPD1/MDM2/USP47/EFNA1/TP63/SIAH2/DHCR24/BIRC6/NCSTN/PPARG/BCAP31/VCP/CAST/NRDC/GPC3/PMAIP1/USP14/PEBP1/ANXA2 35 GO:0060148 positive regulation of posttranscriptional gene silencing 5/998 31/18722 0.0228244242502333 0.13976181275308 EGFR/PUM1/EIF4G1/FMR1/AGO2 5 GO:0060390 regulation of SMAD protein signal transduction 5/998 31/18722 0.0228244242502333 0.13976181275308 LRP1/PARP1/TGFBR1/PPARG/SPTBN1 5 GO:0071168 protein localization to chromatin 5/998 31/18722 0.0228244242502333 0.13976181275308 SETD2/RAD21/VCP/WAPL/NIPBL 5 GO:0051961 negative regulation of nervous system development 14/998 145/18722 0.0228857375347421 0.13976181275308 SEMA6A/SEMA6D/NRP1/BMP7/NF1/PRTG/RTN4/SEMA3F/DICER1/RYK/PCM1/CTNNB1/SEMA4B/CTNNA1 14 GO:0014033 neural crest cell differentiation 10/998 91/18722 0.0228983131729442 0.13976181275308 NRP2/SEMA6A/SEMA6D/NRP1/LAMA5/BMP7/FOLR1/ISL1/SEMA3F/SEMA4B 10 GO:0042147 retrograde transport, endosome to Golgi 10/998 91/18722 0.0228983131729442 0.13976181275308 RHOBTB3/CLTC/SPAG9/ERC1/TMEM87A/RAB6A/GCC2/EVI5/ARL1/VPS35 10 GO:0016601 Rac protein signal transduction 6/998 42/18722 0.0229645482633402 0.13976181275308 HACD3/WASF2/PIK3CB/KRAS/NCKAP1/EPS8 6 GO:0021795 cerebral cortex cell migration 6/998 42/18722 0.0229645482633402 0.13976181275308 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:0045773 positive regulation of axon extension 6/998 42/18722 0.0229645482633402 0.13976181275308 NRP1/GOLGA4/LRP1/CDKL5/MACF1/MAP3K13 6 GO:0010587 miRNA catabolic process 3/998 12/18722 0.0231374352149676 0.13976181275308 KCNQ1OT1/LIN28B/SND1 3 GO:0031453 positive regulation of heterochromatin assembly 3/998 12/18722 0.0231374352149676 0.13976181275308 DNMT1/TPR/MPHOSPH8 3 GO:0034333 adherens junction assembly 3/998 12/18722 0.0231374352149676 0.13976181275308 DLG5/JAM3/CTNNB1 3 GO:0035112 genitalia morphogenesis 3/998 12/18722 0.0231374352149676 0.13976181275308 TP63/CTNNB1/NIPBL 3 GO:0045916 negative regulation of complement activation 3/998 12/18722 0.0231374352149676 0.13976181275308 CD46/CD55/CD59 3 GO:0060601 lateral sprouting from an epithelium 3/998 12/18722 0.0231374352149676 0.13976181275308 BMP7/TP63/FGFR2 3 GO:0120263 positive regulation of heterochromatin organization 3/998 12/18722 0.0231374352149676 0.13976181275308 DNMT1/TPR/MPHOSPH8 3 GO:0007350 blastoderm segmentation 4/998 21/18722 0.0232356356003971 0.13976181275308 NRP2/NRP1/SEMA3F/FZD5 4 GO:0032288 myelin assembly 4/998 21/18722 0.0232356356003971 0.13976181275308 ITGB4/EPB41L3/DICER1/GPC1 4 GO:0035330 regulation of hippo signaling 4/998 21/18722 0.0232356356003971 0.13976181275308 DLG5/MAPK14/VGLL4/SHANK2 4 GO:1902307 positive regulation of sodium ion transmembrane transport 4/998 21/18722 0.0232356356003971 0.13976181275308 ANK3/DMD/SLC9A1/ACTN4 4 GO:2000291 regulation of myoblast proliferation 4/998 21/18722 0.0232356356003971 0.13976181275308 PAXBP1/MALAT1/ZNF609/MEIS2 4 GO:0045600 positive regulation of fat cell differentiation 8/998 66/18722 0.0235752280121106 0.141641272095776 BMP7/LRP5/ADIRF/CDS1/KLF5/PPARG/MAPK14/HNRNPU 8 GO:0010594 regulation of endothelial cell migration 20/998 232/18722 0.0236262925793421 0.14178491213419 MET/NRP2/NRP1/SERPINF1/NR2F2/NF1/CALR/PLPP3/ATP2B4/EFNA1/P2RX4/PPARG/PIK3CB/PTPRM/PTK2/GATA3/PLK2/EMC10/ANXA3/NFE2L2 20 GO:0032330 regulation of chondrocyte differentiation 7/998 54/18722 0.0238569042820691 0.143004474462322 EFEMP1/GLG1/SCIN/GLI3/TGFBR1/CTNNB1/LTBP3 7 GO:0060541 respiratory system development 18/998 203/18722 0.0239618345329089 0.143468736348988 EGFR/MME/DAG1/LAMA5/DLG5/YAP1/GLI3/MAN1A2/KRAS/ERRFI1/FGFR2/CTNNB1/MMP14/MAN2A1/ALDH1A3/ASS1/LTBP3/GPC3 18 GO:0045786 negative regulation of cell cycle 30/998 385/18722 0.0243827561414711 0.145696459031574 EGFR/BMP7/NR2F2/DLG1/CDK6/FOXO4/PRKDC/CTDSPL/MDM2/USP47/ATRX/TPR/CCND1/LATS2/WEE1/BRD7/RAD21/EIF2AK4/MAPK14/CDKN1C/CTNNB1/IPO7/WAPL/GATA3/BCL2/PLK2/PDCD4/XPC/HEXIM1/PPP1R10 30 GO:0060420 regulation of heart growth 9/998 79/18722 0.0243897156088098 0.145696459031574 GJA1/TGFBR3/YAP1/DUSP9/TGFBR1/MAPK14/FGFR2/VGLL4/YY1 9 GO:0036294 cellular response to decreased oxygen levels 15/998 161/18722 0.0252627222786431 0.150739054876338 BMP7/P4HB/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/MALAT1/BCL2/STC2/HILPDA/PMAIP1/LMNA/SLC29A1/NFE2L2 15 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 13/998 133/18722 0.0253168992054896 0.150889875287513 MDM2/RNF217/HECTD1/FMR1/TMTC3/BCAP31/VCP/PTK2/PLK2/HSPA1B/GSK3B/NFE2L2/TMEM259 13 GO:0006458 'de novo' protein folding 6/998 43/18722 0.025524750979516 0.151170600519792 HSPA5/HSPD1/DNAJB14/DNAJB4/HSPA1B/HSPA9 6 GO:0006509 membrane protein ectodomain proteolysis 6/998 43/18722 0.025524750979516 0.151170600519792 DAG1/SPPL2A/NCSTN/NRDC/SH3D19/SPPL2B 6 GO:0014002 astrocyte development 6/998 43/18722 0.025524750979516 0.151170600519792 EGFR/APP/CDK6/NF1/LRP1/KRAS 6 GO:0016266 O-glycan processing 6/998 43/18722 0.025524750979516 0.151170600519792 GALNT11/C1GALT1/GXYLT1/B3GNT3/B3GNT2/GCNT4 6 GO:0032365 intracellular lipid transport 6/998 43/18722 0.025524750979516 0.151170600519792 ABCA1/SYT7/PLEKHA8/CPT2/SGPP1/ANXA2 6 GO:0061077 chaperone-mediated protein folding 8/998 67/18722 0.0255666807621101 0.151170600519792 HSPA5/PDIA4/DNAJB14/DNAJB4/HSPA1B/P3H1/PPIB/HSPA9 8 GO:0061180 mammary gland epithelium development 8/998 67/18722 0.0255666807621101 0.151170600519792 LRP5/KDM5B/CCND1/RTN4/IRF6/FGFR2/DDR1/GATA3 8 GO:0002062 chondrocyte differentiation 11/998 106/18722 0.025716057176281 0.151538978010568 EFEMP1/GLG1/TRIP11/SERPINH1/SCIN/GLI3/CREB3L2/TGFBR1/MAPK14/CTNNB1/LTBP3 11 GO:0006766 vitamin metabolic process 11/998 106/18722 0.025716057176281 0.151538978010568 LRP2/SLC2A1/SLC19A1/MTR/SLC52A1/SLC19A3/FOLR1/AASDHPPT/SLC52A3/TTPA/SLC52A2 11 GO:0046620 regulation of organ growth 11/998 106/18722 0.025716057176281 0.151538978010568 SLC6A4/GJA1/TGFBR3/YAP1/DUSP9/LATS2/TGFBR1/MAPK14/FGFR2/VGLL4/YY1 11 GO:0009954 proximal/distal pattern formation 5/998 32/18722 0.0258999885820519 0.151936899311116 PBX1/GLI3/IRX2/TP63/CTNNB1 5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 5/998 32/18722 0.0258999885820519 0.151936899311116 NR2F2/LATS2/CDKN1C/IPO7/HEXIM1 5 GO:0060317 cardiac epithelial to mesenchymal transition 5/998 32/18722 0.0258999885820519 0.151936899311116 TGFBR3/EFNA1/RTN4/TGFBR1/PDCD4 5 GO:1901532 regulation of hematopoietic progenitor cell differentiation 5/998 32/18722 0.0258999885820519 0.151936899311116 PRKDC/N4BP2L2/DHX36/NFE2L2/HSPA9 5 GO:0032409 regulation of transporter activity 25/998 310/18722 0.0261781763116196 0.153360193201435 APP/TCAF1/AHNAK/UTRN/AKAP9/ITGB1/GJA1/DLG1/FXYD3/SLC5A3/ANK3/DMD/SLC9A1/HOMER1/NDFIP2/FMR1/NEDD4/ACTN4/PPARG/AHCYL1/GOPC/BCL2/ABCB1/STOM/GPD1L 25 GO:0001570 vasculogenesis 9/998 80/18722 0.0262307321449686 0.153360193201435 ITGAV/RASA1/ITGB8/AMOT/TGFBR3/YAP1/SETD2/CTNNB1/QKI 9 GO:1901264 carbohydrate derivative transport 9/998 80/18722 0.0262307321449686 0.153360193201435 GJA1/SLC35B4/CD47/SLC19A1/PLEKHA8/CLN3/SLC35D1/SLC29A3/SLC29A1 9 GO:0030522 intracellular receptor signaling pathway 22/998 265/18722 0.0266993071645369 0.155925148440769 NR2F2/PARP1/CALR/YAP1/SKP2/ISL1/ESRRG/DDX17/PUM1/TP63/UFL1/ANKRD17/NEDD4/ACTN4/DCBLD2/PPARG/TRIM24/NR2F6/UBR5/RBFOX2/HSPA1B/TMF1 22 GO:0070507 regulation of microtubule cytoskeleton organization 14/998 148/18722 0.0267364190830621 0.155967423500187 MET/CLIP1/AKAP9/CLTC/DYNC1H1/TPR/CAMSAP2/GNAI1/OCLN/HSPA1B/GSK3B/GPSM2/PHLDB2/HNRNPU 14 GO:0032727 positive regulation of interferon-alpha production 4/998 22/18722 0.0272326171603451 0.157979437993513 HSPD1/TLR3/SETD2/DHX36 4 GO:0035024 negative regulation of Rho protein signal transduction 4/998 22/18722 0.0272326171603451 0.157979437993513 MET/KANK1/ITGB1/CCDC125 4 GO:0051151 negative regulation of smooth muscle cell differentiation 4/998 22/18722 0.0272326171603451 0.157979437993513 DNMT1/FOXO4/ANKRD17/PDCD4 4 GO:0060343 trabecula formation 4/998 22/18722 0.0272326171603451 0.157979437993513 FBN2/ADAMTS1/TGFBR3/ADGRG6 4 GO:1900120 regulation of receptor binding 4/998 22/18722 0.0272326171603451 0.157979437993513 NRP1/ATP2A2/PHLDA2/ANXA2 4 GO:0045765 regulation of angiogenesis 27/998 342/18722 0.0272734262472596 0.158040575401712 SEMA6A/NRP1/ITGB8/SERPINF1/ITGB1/NF1/AMOT/ADAMTS1/FOXO4/GTF2I/ATP2B4/GAB1/ISL1/EFNA1/TLR3/COL4A2/TJP1/EPN2/PPARG/PIK3CB/PTPRM/CTNNB1/AGO2/PLK2/EMC10/ANXA3/NFE2L2 27 GO:0030324 lung development 16/998 177/18722 0.0273747405749518 0.15845179660956 EGFR/MME/DAG1/LAMA5/DLG5/YAP1/GLI3/MAN1A2/KRAS/ERRFI1/FGFR2/CTNNB1/MMP14/MAN2A1/LTBP3/GPC3 16 GO:0050657 nucleic acid transport 15/998 163/18722 0.0278313455172387 0.160560723696689 IGF2BP3/NCBP3/TPR/LRPPRC/FMR1/SETD2/MYO1C/RANBP17/RANBP2/ATXN2/QKI/AGFG1/PABPN1/HNRNPA2B1/TOMM20 15 GO:0050658 RNA transport 15/998 163/18722 0.0278313455172387 0.160560723696689 IGF2BP3/NCBP3/TPR/LRPPRC/FMR1/SETD2/MYO1C/RANBP17/RANBP2/ATXN2/QKI/AGFG1/PABPN1/HNRNPA2B1/TOMM20 15 GO:0072331 signal transduction by p53 class mediator 15/998 163/18722 0.0278313455172387 0.160560723696689 PERP/PTTG1IP/MDM2/ATRX/USP10/TP63/SMYD2/PLA2R1/TRIM24/BCL2/PLK2/MYO6/PMAIP1/HEXIM1/SHISA5 15 GO:0042752 regulation of circadian rhythm 12/998 121/18722 0.0279568606584356 0.160929183569672 MAGED1/ADRB1/DDB1/PRKDC/OPN3/ZFHX3/USP9X/SFPQ/SIAH2/PPARG/NR2F6/GSK3B 12 GO:1904019 epithelial cell apoptotic process 12/998 121/18722 0.0279568606584356 0.160929183569672 ANO6/YAP1/DNMT3A/PRKCI/PLA2R1/CAST/TCF7L2/GATA3/PDCD4/TIA1/NFE2L2/KRT18 12 GO:0016525 negative regulation of angiogenesis 14/998 149/18722 0.0281204987689863 0.161140739594487 SEMA6A/SERPINF1/AMOT/ADAMTS1/FOXO4/GTF2I/ATP2B4/COL4A2/EPN2/PPARG/PIK3CB/PTPRM/CTNNB1/PLK2 14 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 9/998 81/18722 0.0281677837794387 0.161140739594487 FBN2/FBN1/PEG10/HSPA5/GLG1/TGFBR3/ZNF451/PPARG/EID2 9 GO:0071260 cellular response to mechanical stimulus 9/998 81/18722 0.0281677837794387 0.161140739594487 EGFR/SLC2A1/DAG1/GJA1/TMEM150C/TLR3/SLC9A1/SLC38A2/PLEC 9 GO:1903533 regulation of protein targeting 9/998 81/18722 0.0281677837794387 0.161140739594487 TCAF1/LMAN1/ANK3/HUWE1/LEPROT/NPEPPS/FZD5/MYO1C/STOM 9 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 6/998 44/18722 0.0282679654730833 0.161140739594487 DLG5/DLG1/FAT1/PRKCI/PARD3/OPHN1 6 GO:0048806 genitalia development 6/998 44/18722 0.0282679654730833 0.161140739594487 LRP2/LGR4/TP63/DHCR24/CTNNB1/NIPBL 6 GO:0097178 ruffle assembly 6/998 44/18722 0.0282679654730833 0.161140739594487 KANK1/TACSTD2/COBL/SH3YL1/RDX/EPS8 6 GO:1903573 negative regulation of response to endoplasmic reticulum stress 6/998 44/18722 0.0282679654730833 0.161140739594487 HSPA5/USP25/LPCAT3/UFL1/PTPN1/USP14 6 GO:0010332 response to gamma radiation 7/998 56/18722 0.0285311224308803 0.161140739594487 HSPA5/PARP1/YAP1/PRKDC/MDM2/GATA3/BCL2 7 GO:0030166 proteoglycan biosynthetic process 7/998 56/18722 0.0285311224308803 0.161140739594487 EXTL2/CHPF/HS6ST2/GLCE/CTNNB1/TCF7L2/EXT2 7 GO:0071385 cellular response to glucocorticoid stimulus 7/998 56/18722 0.0285311224308803 0.161140739594487 EGFR/ATP2B1/SERPINF1/ISL1/ERRFI1/ASS1/HNRNPU 7 GO:0006983 ER overload response 3/998 13/18722 0.0289100713654631 0.161140739594487 HSPA5/CCDC47/GSK3B 3 GO:0010745 negative regulation of macrophage derived foam cell differentiation 3/998 13/18722 0.0289100713654631 0.161140739594487 ITGAV/ABCA1/PPARG 3 GO:0010958 regulation of amino acid import across plasma membrane 3/998 13/18722 0.0289100713654631 0.161140739594487 ITGB1/SLC43A2/ARL6IP5 3 GO:0010960 magnesium ion homeostasis 3/998 13/18722 0.0289100713654631 0.161140739594487 EGFR/ANK3/TRPM7 3 GO:0014745 negative regulation of muscle adaptation 3/998 13/18722 0.0289100713654631 0.161140739594487 ATP2B4/ERRFI1/LMNA 3 GO:0015809 arginine transport 3/998 13/18722 0.0289100713654631 0.161140739594487 SLC38A9/CLN3/SLC7A2 3 GO:0021819 layer formation in cerebral cortex 3/998 13/18722 0.0289100713654631 0.161140739594487 ADGRG1/GLI3/CTNNB1 3 GO:0032429 regulation of phospholipase A2 activity 3/998 13/18722 0.0289100713654631 0.161140739594487 EGFR/LRP1/PLA2R1 3 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 3/998 13/18722 0.0289100713654631 0.161140739594487 PARP1/YAP1/SKP2 3 GO:0033689 negative regulation of osteoblast proliferation 3/998 13/18722 0.0289100713654631 0.161140739594487 PLXNB1/BCL2/ATRAID 3 GO:0048012 hepatocyte growth factor receptor signaling pathway 3/998 13/18722 0.0289100713654631 0.161140739594487 MET/NRP1/PTPN1 3 GO:0051481 negative regulation of cytosolic calcium ion concentration 3/998 13/18722 0.0289100713654631 0.161140739594487 ATP2B1/LRP1/GTF2I 3 GO:0060347 heart trabecula formation 3/998 13/18722 0.0289100713654631 0.161140739594487 ADAMTS1/TGFBR3/ADGRG6 3 GO:0061000 negative regulation of dendritic spine development 3/998 13/18722 0.0289100713654631 0.161140739594487 EFNA1/PLK2/HDAC2 3 GO:0071696 ectodermal placode development 3/998 13/18722 0.0289100713654631 0.161140739594487 NRP1/CTNNB1/HDAC2 3 GO:0090161 Golgi ribbon formation 3/998 13/18722 0.0289100713654631 0.161140739594487 TRIP11/GCC2/GOLGA2 3 GO:1903789 regulation of amino acid transmembrane transport 3/998 13/18722 0.0289100713654631 0.161140739594487 ITGB1/SLC43A2/ARL6IP5 3 GO:1905269 positive regulation of chromatin organization 3/998 13/18722 0.0289100713654631 0.161140739594487 DNMT1/TPR/MPHOSPH8 3 GO:0034440 lipid oxidation 11/998 108/18722 0.0290295512453551 0.161140739594487 SLC27A2/HADHA/CROT/ECHDC2/ACADVL/ECI2/CPT2/MAPK14/ADH5/ECHDC1/ETFA 11 GO:0030336 negative regulation of cell migration 27/998 344/18722 0.0290736039686515 0.161140739594487 CDH1/TCAF1/ADGRG1/SEMA6D/DAG1/KANK1/DPP4/SERPINF1/DLG5/GJA1/NR2F2/NF1/LRP1/CALR/GNA12/ATP2B4/TACSTD2/MARVELD3/STK26/S1PR2/MIA3/PPARG/PTPRM/BCL2/SRGAP1/PHLDB2/NFE2L2 27 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 15/998 164/18722 0.0291858393704767 0.161140739594487 GNA12/MDM2/RNF217/HECTD1/RAD23B/UFL1/BCAP31/VCP/PTK2/SMARCC1/PLK2/HSPA1B/GSK3B/NFE2L2/USP14 15 GO:2001242 regulation of intrinsic apoptotic signaling pathway 15/998 164/18722 0.0291858393704767 0.161140739594487 P4HB/PARP1/PTTG1IP/MDM2/USP47/SIAH1/SFPQ/ERP29/BCLAF1/PTPN1/BCAP31/BCL2/SERINC3/PMAIP1/NFE2L2 15 GO:0010259 multicellular organism aging 5/998 33/18722 0.0292281709243399 0.161140739594487 CTSV/TFCP2L1/TP63/SEC63/PRDM2 5 GO:0031116 positive regulation of microtubule polymerization 5/998 33/18722 0.0292281709243399 0.161140739594487 MET/CLIP1/AKAP9/OCLN/HSPA1B 5 GO:0046685 response to arsenic-containing substance 5/998 33/18722 0.0292281709243399 0.161140739594487 SERPINF1/VCP/DHX36/SLC38A2/ALAD 5 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 5/998 33/18722 0.0292281709243399 0.161140739594487 KANK1/YAP1/TACSTD2/LIMK2/MAP4 5 GO:1902275 regulation of chromatin organization 5/998 33/18722 0.0292281709243399 0.161140739594487 DNMT1/TPR/MPHOSPH8/TLK1/HNRNPU 5 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 5/998 33/18722 0.0292281709243399 0.161140739594487 NR2F2/LATS2/CDKN1C/IPO7/HEXIM1 5 GO:2000036 regulation of stem cell population maintenance 5/998 33/18722 0.0292281709243399 0.161140739594487 BMP7/NCOA3/YAP1/ZC3H13/TP63 5 GO:0044262 cellular carbohydrate metabolic process 23/998 283/18722 0.0295834210202065 0.162927258593353 AGL/DDB1/SLC5A3/ISYNA1/SLC35B4/IDH1/IL6ST/PHKB/B4GALT1/UGP2/B3GNT3/SORBS1/FAM3C/GNPTAB/B3GNT2/GAA/GUSB/RANBP2/EXT2/GSK3B/PMAIP1/PHLDA2/GLB1 23 GO:0003158 endothelium development 13/998 136/18722 0.0297072015923589 0.163267088062183 MET/NRP1/GJA1/NR2F2/GJA5/FSTL1/TJP1/S1PR2/EZR/CTNNB1/RDX/FASN/MARVELD2 13 GO:0008585 female gonad development 10/998 95/18722 0.029832494779349 0.163267088062183 HSPA5/NR2F2/ADAMTS1/IDH1/ZFX/ARID5B/PLEKHA1/MMP14/BCL2/CTNNA1 10 GO:0008593 regulation of Notch signaling pathway 10/998 95/18722 0.029832494779349 0.163267088062183 GALNT11/CD46/BMP7/AAK1/YAP1/IL6ST/TP63/EPN2/PRKCI/MMP14 10 GO:0042982 amyloid precursor protein metabolic process 10/998 95/18722 0.029832494779349 0.163267088062183 DLG1/EFNA1/CLN3/DHCR24/PAWR/NCSTN/RTN4/AGO2/FLOT2/NSG1 10 GO:0006368 transcription elongation from RNA polymerase II promoter 8/998 69/18722 0.0298952951900875 0.163267088062183 BRD4/SETD2/CTNNB1/TCERG1/NELFCD/ELL/HEXIM1/HNRNPU 8 GO:0007004 telomere maintenance via telomerase 8/998 69/18722 0.0298952951900875 0.163267088062183 RAD50/MAP3K4/DCP2/PKIB/HSP90AA1/CTNNB1/TNKS2/HNRNPU 8 GO:0010611 regulation of cardiac muscle hypertrophy 8/998 69/18722 0.0298952951900875 0.163267088062183 PARP1/ATP2B4/IL6ST/SLC9A1/P2RX4/ERRFI1/YY1/LMNA 8 GO:1901224 positive regulation of NIK/NF-kappaB signaling 8/998 69/18722 0.0298952951900875 0.163267088062183 EGFR/APP/NFAT5/CALR/TRIM44/TLR3/ACTN4/PDCD4 8 GO:0006941 striated muscle contraction 16/998 179/18722 0.0299718093906504 0.163513915181385 DSP/DSC2/AKAP9/GJA1/DLG1/GJA5/DSG2/DMD/SLC9A1/HOMER1/P2RX4/PKP2/GAA/PPP1R13L/ATP2A2/GPD1L 16 GO:1901990 regulation of mitotic cell cycle phase transition 24/998 299/18722 0.0303199899585084 0.165240780347988 EGFR/APP/DDB1/BRD4/PBX1/DLG1/ADAMTS1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/TPR/CCND1/EIF4G1/ANKRD17/WEE1/BRD7/RAD21/RDX/BCL2/ANAPC5/PLK2/XPC 24 GO:0044772 mitotic cell cycle phase transition 32/998 424/18722 0.0305002866715461 0.16605004870922 EGFR/APP/ITGB1/DDB1/BRD4/PBX1/DLG1/CDK6/ADAMTS1/FOXO4/PRKDC/CTDSPL/SKP2/MDM2/USP47/TPR/CCND1/EIF4G1/ANKRD17/LATS2/WEE1/BRD7/RAD21/RDX/EPS8/BCL2/ANAPC5/ABCB1/PLK2/XPC/CUL5/BCAT1 32 GO:2000181 negative regulation of blood vessel morphogenesis 14/998 151/18722 0.0310455466298183 0.16870691909748 SEMA6A/SERPINF1/AMOT/ADAMTS1/FOXO4/GTF2I/ATP2B4/COL4A2/EPN2/PPARG/PIK3CB/PTPRM/CTNNB1/PLK2 14 GO:0032984 protein-containing complex disassembly 19/998 224/18722 0.0310649752178831 0.16870691909748 IGF1R/LIMA1/SCIN/CLN3/SWAP70/CAMSAP2/TRIOBP/UVRAG/VCP/RDX/EPS8/SMARCC1/SPTAN1/SPTBN1/ATP2A2/ADD3/SNX14/GSK3B/MICAL3 19 GO:0051205 protein insertion into membrane 7/998 57/18722 0.0310852434728549 0.16870691909748 EGFR/CCDC47/EMC1/TRAM2/HSP90AA1/EMC10/EMC7 7 GO:0003254 regulation of membrane depolarization 6/998 45/18722 0.0311985016413194 0.168747587117084 IFI6/GJA5/ANK3/PARP1/BCL2/GPD1L 6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 6/998 45/18722 0.0311985016413194 0.168747587117084 P4HB/ARL6IP5/PARP1/SFPQ/BCL2/NFE2L2 6 GO:1904646 cellular response to amyloid-beta 6/998 45/18722 0.0311985016413194 0.168747587117084 APP/GJA1/IGF1R/LRP1/PARP1/GSK3B 6 GO:0071482 cellular response to light stimulus 12/998 123/18722 0.031236720337606 0.168747587117084 MME/DDB1/PARP1/OPN3/MDM2/USP47/FMR1/NEDD4/EIF2AK4/DHX36/XPC/YY1 12 GO:0010977 negative regulation of neuron projection development 13/998 137/18722 0.0312866623883045 0.168747587117084 SEMA6A/SEMA6D/KANK1/NRP1/LRP1/MDM2/EFNA1/RTN4/SEMA3F/RYK/SEMA4B/MYLIP/HDAC2 13 GO:0050714 positive regulation of protein secretion 13/998 137/18722 0.0312866623883045 0.168747587117084 EGFR/MYH10/WLS/GJA1/LRP1/EXPH5/FRMD4A/KCNN4/ISL1/EXOC1/CD2AP/EZR/TCF7L2 13 GO:0048660 regulation of smooth muscle cell proliferation 16/998 180/18722 0.0313366187469198 0.168842607304095 EGFR/GJA1/ADAMTS1/TGM2/DNMT1/PRKDC/GNA12/SKP2/MDM2/SF1/S1PR2/PPARG/FGFR2/CTNNB1/TCF7L2/PDCD4 16 GO:0045936 negative regulation of phosphate metabolic process 33/998 441/18722 0.0314762691460762 0.169119182453402 FBLN1/BMP7/NR2F2/NF1/LRP5/LRP1/PARP1/PRKDC/CTDSPL/PLPP3/DMD/SPAG9/EIF4G1/PKIB/LATS2/SUZ12/PARD3/SWAP70/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/BOD1L1/PLEC/OCLN/PDCD4/GSK3B/HEXIM1/GPD1L/HNRNPU 33 GO:0003002 regionalization 26/998 331/18722 0.0314907535056441 0.169119182453402 LRP2/NRP2/ADGRG1/WLS/NRP1/PBX1/NR2F2/LRP5/PGAP1/PRKDC/ISL1/GLI3/COBL/BPTF/IRX2/TP63/AHI1/SEMA3F/TGFBR1/FGFR2/TRA2B/CTNNB1/FZD5/BHLHE41/GPC3/YY1 26 GO:0007346 regulation of mitotic cell cycle 34/998 457/18722 0.0315397998216634 0.169119182453402 EGFR/APP/BMP7/DDB1/BRD4/PBX1/DLG1/LRP5/ADAMTS1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/OBSL1/TPR/CCND1/EIF4G1/ANKRD17/WEE1/BRD7/PKN2/RAD21/CDKN1C/CTNNB1/RDX/BCL2/ANAPC5/USP22/PLK2/MEIS2/XPC/PPP1R10/HNRNPU 34 GO:0006622 protein targeting to lysosome 4/998 23/18722 0.0316146949003103 0.169119182453402 NEDD4/GNPTAB/GCC2/ZFYVE16 4 GO:0021871 forebrain regionalization 4/998 23/18722 0.0316146949003103 0.169119182453402 ADGRG1/PGAP1/GLI3/TRA2B 4 GO:0060575 intestinal epithelial cell differentiation 4/998 23/18722 0.0316146949003103 0.169119182453402 YAP1/IL6ST/KLF5/YIPF6 4 GO:2000810 regulation of bicellular tight junction assembly 4/998 23/18722 0.0316146949003103 0.169119182453402 GJA1/TJP1/FZD5/MYO1C 4 GO:1904035 regulation of epithelial cell apoptotic process 10/998 96/18722 0.0317753722875265 0.169804727444397 ANO6/YAP1/PRKCI/PLA2R1/CAST/TCF7L2/GATA3/PDCD4/TIA1/NFE2L2 10 GO:0043414 macromolecule methylation 25/998 316/18722 0.031982167721582 0.170735069196707 BRD4/DNMT1/PARP1/ASH1L/DNMT3A/ZC3H13/ATRX/TET2/SMYD2/RAB6A/MPHOSPH8/SETD2/SUZ12/NSD1/PAXBP1/TARBP1/RIF1/CTNNB1/KMT2C/GATA3/CMTR1/PRDM2/PCMTD1/PCMTD2/LMNA 25 GO:0051236 establishment of RNA localization 15/998 166/18722 0.0320396315946246 0.170867126205858 IGF2BP3/NCBP3/TPR/LRPPRC/FMR1/SETD2/MYO1C/RANBP17/RANBP2/ATXN2/QKI/AGFG1/PABPN1/HNRNPA2B1/TOMM20 15 GO:0010563 negative regulation of phosphorus metabolic process 33/998 442/18722 0.0323489549788335 0.172340708106622 FBLN1/BMP7/NR2F2/NF1/LRP5/LRP1/PARP1/PRKDC/CTDSPL/PLPP3/DMD/SPAG9/EIF4G1/PKIB/LATS2/SUZ12/PARD3/SWAP70/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/BOD1L1/PLEC/OCLN/PDCD4/GSK3B/HEXIM1/GPD1L/HNRNPU 33 GO:1901343 negative regulation of vasculature development 14/998 152/18722 0.0325884913018797 0.173439870629066 SEMA6A/SERPINF1/AMOT/ADAMTS1/FOXO4/GTF2I/ATP2B4/COL4A2/EPN2/PPARG/PIK3CB/PTPRM/CTNNB1/PLK2 14 GO:0030323 respiratory tube development 16/998 181/18722 0.0327466491817709 0.173579396776072 EGFR/MME/DAG1/LAMA5/DLG5/YAP1/GLI3/MAN1A2/KRAS/ERRFI1/FGFR2/CTNNB1/MMP14/MAN2A1/LTBP3/GPC3 16 GO:0010614 negative regulation of cardiac muscle hypertrophy 5/998 34/18722 0.032814185906528 0.173579396776072 ATP2B4/P2RX4/ERRFI1/YY1/LMNA 5 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 5/998 34/18722 0.032814185906528 0.173579396776072 PTTG1IP/MDM2/SMYD2/PLA2R1/PMAIP1 5 GO:0051085 chaperone cofactor-dependent protein refolding 5/998 34/18722 0.032814185906528 0.173579396776072 HSPA5/DNAJB14/DNAJB4/HSPA1B/HSPA9 5 GO:0070884 regulation of calcineurin-NFAT signaling cascade 5/998 34/18722 0.032814185906528 0.173579396776072 NFAT5/ATP2B4/SLC9A1/SPPL3/GSK3B 5 GO:1990000 amyloid fibril formation 5/998 34/18722 0.032814185906528 0.173579396776072 APP/MDM2/USP9X/SIAH1/SIAH2 5 GO:1901342 regulation of vasculature development 27/998 348/18722 0.0329455600273788 0.17409794423375 SEMA6A/NRP1/ITGB8/SERPINF1/ITGB1/NF1/AMOT/ADAMTS1/FOXO4/GTF2I/ATP2B4/GAB1/ISL1/EFNA1/TLR3/COL4A2/TJP1/EPN2/PPARG/PIK3CB/PTPRM/CTNNB1/AGO2/PLK2/EMC10/ANXA3/NFE2L2 27 GO:1903522 regulation of blood circulation 21/998 256/18722 0.0333970219715458 0.176305209012579 EGFR/DSP/ATP2B1/DSC2/ADRB1/AKAP9/GJA1/DLG1/GJA5/DSG2/ATP2B4/MDM2/DMD/ISL1/SLC9A1/P2RX4/PKP2/CYP2J2/GAA/ATP2A2/GPD1L 21 GO:0030100 regulation of endocytosis 18/998 211/18722 0.0334828059342165 0.176401341859278 ITGAV/LRPAP1/AAK1/ANO6/LRP1/CLN3/CD2AP/STON1/AHI1/FMR1/PTPN1/PIK3CB/RAB31/ATXN2/OPHN1/ZFYVE16/GPC3/ANXA2 18 GO:0050807 regulation of synapse organization 18/998 211/18722 0.0334828059342165 0.176401341859278 APP/NRP2/DAG1/DLG5/PPP1R9A/EFNA1/CDKL5/CLN3/HOMER1/EIF4G1/SEMA3F/TPBG/NEDD4/CLSTN1/VCP/MAPK14/DHX36/VPS35 18 GO:1903034 regulation of response to wounding 15/998 167/18722 0.0335406626836214 0.176528024063697 KANK1/ITGB1/GJA1/CLDN4/ANO6/LRP1/PLPP3/FERMT1/FERMT2/PTK2/ARFGEF1/OCLN/PHLDB2/NFE2L2/ANXA2 15 GO:0071241 cellular response to inorganic substance 19/998 226/18722 0.0335849923914499 0.176583328575791 EGFR/APP/CDH1/SERPINF1/HSPA5/ANK3/PARP1/CALR/FUS/MTR/TFAP2A/SYT7/HSD17B1/ATRX/NCSTN/FMR1/P2RX4/ALAD/NFE2L2 19 GO:0001954 positive regulation of cell-matrix adhesion 7/998 58/18722 0.0337882868242718 0.177117113965385 DAG1/NRP1/UTRN/CDK6/FERMT1/FERMT2/GSK3B 7 GO:0097035 regulation of membrane lipid distribution 7/998 58/18722 0.0337882868242718 0.177117113965385 ATP10D/ANO6/KCNN4/ABCA1/TMEM30B/ABCB1/TMEM30A 7 GO:1902808 positive regulation of cell cycle G1/S phase transition 7/998 58/18722 0.0337882868242718 0.177117113965385 EGFR/ADAMTS1/MDM2/CCND1/EIF4G1/ANKRD17/RDX 7 GO:0061028 establishment of endothelial barrier 6/998 46/18722 0.0343202475669049 0.179365377924735 TJP1/S1PR2/EZR/RDX/FASN/MARVELD2 6 GO:0061462 protein localization to lysosome 6/998 46/18722 0.0343202475669049 0.179365377924735 RNF128/RTN4/NEDD4/GNPTAB/GCC2/ZFYVE16 6 GO:0070828 heterochromatin organization 6/998 46/18722 0.0343202475669049 0.179365377924735 DNMT1/DNMT3A/TPR/MPHOSPH8/SMARCA5/HP1BP3 6 GO:0006112 energy reserve metabolic process 9/998 84/18722 0.0345768136142378 0.17998558711858 AGL/IL6ST/GFPT1/PHKB/UGP2/SORBS1/GAA/GSK3B/PHLDA2 9 GO:0006970 response to osmotic stress 9/998 84/18722 0.0345768136142378 0.17998558711858 EGFR/SLC2A1/NFAT5/TLR3/CLN3/MARVELD3/ERRFI1/MAP7/ABCB1 9 GO:0032370 positive regulation of lipid transport 9/998 84/18722 0.0345768136142378 0.17998558711858 LRP1/ABCA1/LPCAT3/PLA2R1/P2RX4/PPARG/TMEM30A/TMF1/ANXA2 9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 9/998 84/18722 0.0345768136142378 0.17998558711858 DLG1/PRKDC/CTDSPL/MDM2/CCND1/WEE1/BRD7/BCL2/PLK2 9 GO:0016579 protein deubiquitination 13/998 139/18722 0.0346263092109863 0.180063705568286 USP53/USP25/USP27X/USP47/USP9X/USP10/USP48/VCP/USP34/USP22/OTUD4/OTUD7B/USP14 13 GO:0046777 protein autophosphorylation 19/998 227/18722 0.0349003764111808 0.181043050987645 EGFR/AAK1/IGF1R/SLK/EPHB4/EIF2AK1/RAD50/CDKL5/STK26/YES1/EIF2AK4/ERRFI1/TRPM7/TRIM24/FGFR2/DDR1/PTK2/GSK3B/MAP3K13 19 GO:1902806 regulation of cell cycle G1/S phase transition 15/998 168/18722 0.0350922455085414 0.181043050987645 EGFR/DLG1/ADAMTS1/PRKDC/CTDSPL/ATP2B4/MDM2/CCND1/EIF4G1/ANKRD17/WEE1/BRD7/RDX/BCL2/PLK2 15 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 3/998 14/18722 0.0353694525967052 0.181043050987645 S1PR2/EZR/PIK3CB 3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 3/998 14/18722 0.0353694525967052 0.181043050987645 EPN2/NEDD4/PTPN1 3 GO:0031054 pre-miRNA processing 3/998 14/18722 0.0353694525967052 0.181043050987645 LIN28B/DICER1/AGO2 3 GO:0034616 response to laminar fluid shear stress 3/998 14/18722 0.0353694525967052 0.181043050987645 ABCA1/ASS1/NFE2L2 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/998 14/18722 0.0353694525967052 0.181043050987645 HSPA5/GJA1/KDELR1 3 GO:0046479 glycosphingolipid catabolic process 3/998 14/18722 0.0353694525967052 0.181043050987645 HEXB/HEXA/GM2A 3 GO:0071236 cellular response to antibiotic 3/998 14/18722 0.0353694525967052 0.181043050987645 HSPA5/MDM2/SLC9A1 3 GO:0072176 nephric duct development 3/998 14/18722 0.0353694525967052 0.181043050987645 AHI1/GATA3/GPC3 3 GO:0072350 tricarboxylic acid metabolic process 3/998 14/18722 0.0353694525967052 0.181043050987645 IDH1/ASS1/ACO1 3 GO:0072531 pyrimidine-containing compound transmembrane transport 3/998 14/18722 0.0353694525967052 0.181043050987645 SLC19A3/SLC25A36/SLC29A1 3 GO:1901857 positive regulation of cellular respiration 3/998 14/18722 0.0353694525967052 0.181043050987645 IL10RB/OPN3/VCP 3 GO:1903894 regulation of IRE1-mediated unfolded protein response 3/998 14/18722 0.0353694525967052 0.181043050987645 HSPA5/UFL1/PTPN1 3 GO:1904152 regulation of retrograde protein transport, ER to cytosol 3/998 14/18722 0.0353694525967052 0.181043050987645 ERLEC1/BCAP31/UBE2G2 3 GO:1904294 positive regulation of ERAD pathway 3/998 14/18722 0.0353694525967052 0.181043050987645 BCAP31/NFE2L2/TMEM259 3 GO:0030856 regulation of epithelial cell differentiation 14/998 154/18722 0.0358400153611261 0.183272008031772 NCOA3/CD24/YAP1/CCND1/TP63/AHI1/S1PR2/ESRP1/KIAA1109/ERRFI1/GRHL1/CTNNB1/GATA3/SGPP1 14 GO:0031099 regeneration 17/998 198/18722 0.0360766422238302 0.184009668002426 EGFR/DAG1/LRP1/TGFBR3/YAP1/MTR/FOLR1/ISL1/GLI3/SRSF5/CCND1/KLF5/NREP/JAM3/BCL2/CTNNA1/ANXA3 17 GO:0043583 ear development 18/998 213/18722 0.0362477980226763 0.184009668002426 LGR5/TRIP11/TFAP2A/MCOLN3/GLI3/ATP6V1B1/MYO7A/AHI1/ESRP1/TRIOBP/FZD6/FGFR2/DDR1/GATA3/BCL2/ALDH1A3/NIPBL/MYO6 18 GO:0051651 maintenance of location in cell 18/998 213/18722 0.0362477980226763 0.184009668002426 HSP90B1/AKAP9/HSPA5/GJA1/ANK3/CALR/ARHGAP21/SCIN/MCOLN3/DMD/VPS13A/UVRAG/SUN1/GAA/GPSM2/SLC30A7/HNRNPU/KDELR1 18 GO:0016486 peptide hormone processing 4/998 24/18722 0.0363862008281137 0.184009668002426 MME/CTSL/ENPEP/PCSK7 4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 4/998 24/18722 0.0363862008281137 0.184009668002426 HSPA5/ATF6/CHD6/NFE2L2 4 GO:0051570 regulation of histone H3-K9 methylation 4/998 24/18722 0.0363862008281137 0.184009668002426 DNMT1/ATRX/RIF1/LMNA 4 GO:0051647 nucleus localization 4/998 24/18722 0.0363862008281137 0.184009668002426 SYNE2/DYNC1H1/PCM1/SUN1 4 GO:0060571 morphogenesis of an epithelial fold 4/998 24/18722 0.0363862008281137 0.184009668002426 BMP7/TP63/FGFR2/CTNNB1 4 GO:0090343 positive regulation of cell aging 4/998 24/18722 0.0363862008281137 0.184009668002426 PAWR/KRAS/LMNA/YPEL3 4 GO:2000209 regulation of anoikis 4/998 24/18722 0.0363862008281137 0.184009668002426 ITGB1/PTK2/BCL2/TLE1 4 GO:0015748 organophosphate ester transport 13/998 140/18722 0.0363886318033358 0.184009668002426 GJA1/ATP10D/ANO6/CD47/SLC19A1/KCNN4/ABCA1/SLC25A36/PLEKHA8/TMEM30B/ABCB1/TMEM30A/SLC29A1 13 GO:0001701 in utero embryonic development 28/998 367/18722 0.0364071992044639 0.184009668002426 SPINT1/BMP7/ITGB1/SPINT2/NR2F2/AMOT/YAP1/FUT8/N4BP2L2/HECTD1/GLI3/BPTF/BIRC6/RTN4/TGFBR1/KIDINS220/SETD2/CPT2/SLC39A1/FGFR2/CTNNB1/FZD5/MAN2A1/GATA3/ST14/ELL/OTUD7B/PHLDA2 28 GO:0046324 regulation of glucose import 7/998 59/18722 0.0366431362862929 0.184406850409521 OPN3/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 7 GO:0031076 embryonic camera-type eye development 5/998 35/18722 0.0366623847395293 0.184406850409521 BMP7/TFAP2A/FZD5/PPP1R13L/ALDH1A3 5 GO:0032205 negative regulation of telomere maintenance 5/998 35/18722 0.0366623847395293 0.184406850409521 PARP1/RAD50/DCP2/TNKS2/HNRNPU 5 GO:0070536 protein K63-linked deubiquitination 5/998 35/18722 0.0366623847395293 0.184406850409521 USP25/USP27X/VCP/OTUD4/OTUD7B 5 GO:0106056 regulation of calcineurin-mediated signaling 5/998 35/18722 0.0366623847395293 0.184406850409521 NFAT5/ATP2B4/SLC9A1/SPPL3/GSK3B 5 GO:0032092 positive regulation of protein binding 9/998 85/18722 0.0369192026581371 0.18551988169214 APP/NRP1/LRP1/TCF7L2/PLK2/AKTIP/SPPL3/GSK3B/ANXA2 9 GO:0048659 smooth muscle cell proliferation 16/998 184/18722 0.0372556241636186 0.186493314455338 EGFR/GJA1/ADAMTS1/TGM2/DNMT1/PRKDC/GNA12/SKP2/MDM2/SF1/S1PR2/PPARG/FGFR2/CTNNB1/TCF7L2/PDCD4 16 GO:0000271 polysaccharide biosynthetic process 8/998 72/18722 0.0372915189219255 0.186493314455338 AGL/CLTC/UGP2/B3GNT3/SORBS1/B3GNT2/EXT2/GSK3B 8 GO:0005977 glycogen metabolic process 8/998 72/18722 0.0372915189219255 0.186493314455338 AGL/IL6ST/PHKB/UGP2/SORBS1/GAA/GSK3B/PHLDA2 8 GO:0014743 regulation of muscle hypertrophy 8/998 72/18722 0.0372915189219255 0.186493314455338 PARP1/ATP2B4/IL6ST/SLC9A1/P2RX4/ERRFI1/YY1/LMNA 8 GO:0055021 regulation of cardiac muscle tissue growth 8/998 72/18722 0.0372915189219255 0.186493314455338 GJA1/TGFBR3/YAP1/TGFBR1/MAPK14/FGFR2/VGLL4/YY1 8 GO:0010970 transport along microtubule 14/998 155/18722 0.0375504469682275 0.186788010743855 APP/DST/DYNC1H1/ARHGAP21/CLN3/LRPPRC/SFPQ/RAB6A/PURA/PCM1/SUN1/FLOT2/ARMCX3/HNRNPU 14 GO:0010761 fibroblast migration 6/998 47/18722 0.0376366572117478 0.186788010743855 ITGB1/GNA12/CLN3/ARID5B/PTK2/PLEC 6 GO:0035315 hair cell differentiation 6/998 47/18722 0.0376366572117478 0.186788010743855 MCOLN3/MYO7A/ESRP1/TRIOBP/CTNNB1/MYO6 6 GO:0045646 regulation of erythrocyte differentiation 6/998 47/18722 0.0376366572117478 0.186788010743855 CDK6/PRKDC/MAPK14/RBFOX2/HSPA1B/HSPA9 6 GO:0045747 positive regulation of Notch signaling pathway 6/998 47/18722 0.0376366572117478 0.186788010743855 AAK1/YAP1/IL6ST/TP63/EPN2/PRKCI 6 GO:0046677 response to antibiotic 6/998 47/18722 0.0376366572117478 0.186788010743855 HSPA5/MDM2/KDM5B/SLC9A1/SLC1A3/HSP90AA1 6 GO:0051489 regulation of filopodium assembly 6/998 47/18722 0.0376366572117478 0.186788010743855 NRP1/FNBP1L/PPP1R9A/CLN3/FMR1/TGFBR1 6 GO:0072583 clathrin-dependent endocytosis 6/998 47/18722 0.0376366572117478 0.186788010743855 AAK1/CLTC/FNBP1L/CANX/PIK3CB/AP2A2 6 GO:0003300 cardiac muscle hypertrophy 10/998 99/18722 0.0381341547666831 0.189077323871655 PARP1/ATP2B4/IL6ST/SLC9A1/P2RX4/ERRFI1/ATP2A2/HDAC2/YY1/LMNA 10 GO:0042326 negative regulation of phosphorylation 29/998 385/18722 0.0387919797527201 0.192156476554982 FBLN1/BMP7/NR2F2/NF1/LRP5/LRP1/PRKDC/CTDSPL/PLPP3/DMD/SPAG9/EIF4G1/PKIB/LATS2/SUZ12/PARD3/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/PLEC/OCLN/PDCD4/HEXIM1/GPD1L/HNRNPU 29 GO:0001764 neuron migration 14/998 156/18722 0.0393185204307195 0.19458009020738 NRP2/ADGRG1/SEMA6A/NRP1/NR2F2/CDKL5/USP9X/NRCAM/TOP2B/PCM1/CTNNB1/ZNF609/GATA3/NIPBL 14 GO:2001251 negative regulation of chromosome organization 9/998 86/18722 0.0393677399254862 0.194639176279321 PARP1/RAD50/ATRX/TPR/DCP2/RAD21/TNKS2/WAPL/HNRNPU 9 GO:0055008 cardiac muscle tissue morphogenesis 7/998 60/18722 0.0396524232337059 0.195676088566331 LRP2/DSP/TGFBR3/ISL1/TGFBR1/FGFR2/PKP2 7 GO:0060038 cardiac muscle cell proliferation 7/998 60/18722 0.0396524232337059 0.195676088566331 GJA1/TGFBR3/YAP1/TGFBR1/MAPK14/FGFR2/VGLL4 7 GO:0006073 cellular glucan metabolic process 8/998 73/18722 0.0400071814445714 0.196683139663001 AGL/IL6ST/PHKB/UGP2/SORBS1/GAA/GSK3B/PHLDA2 8 GO:0035924 cellular response to vascular endothelial growth factor stimulus 8/998 73/18722 0.0400071814445714 0.196683139663001 NRP2/SEMA6A/NRP1/ATP2B4/GAB1/PIK3CB/MAPK14/MYO1C 8 GO:0044042 glucan metabolic process 8/998 73/18722 0.0400071814445714 0.196683139663001 AGL/IL6ST/PHKB/UGP2/SORBS1/GAA/GSK3B/PHLDA2 8 GO:0099518 vesicle cytoskeletal trafficking 8/998 73/18722 0.0400071814445714 0.196683139663001 CCDC186/DYNC1H1/FNBP1L/MYO7A/CLN3/ACTN4/MYO1C/MYO6 8 GO:0007009 plasma membrane organization 13/998 142/18722 0.0401033965889212 0.196970680706263 DEGS1/ANO6/ANK3/SPESP1/MYOF/FNBP1L/FOLR1/SYT7/CLN3/EPB41L3/SPTBN1/ATP2A2/PLEC 13 GO:0046545 development of primary female sexual characteristics 10/998 100/18722 0.0404357361628849 0.198230026766594 HSPA5/NR2F2/ADAMTS1/IDH1/ZFX/ARID5B/PLEKHA1/MMP14/BCL2/CTNNA1 10 GO:0060840 artery development 10/998 100/18722 0.0404357361628849 0.198230026766594 LRP2/ADAMTS6/NRP1/NF1/GJA5/LRP1/FOLR1/HECTD1/GLI3/TGFBR1 10 GO:0009225 nucleotide-sugar metabolic process 5/998 36/18722 0.0407762521603674 0.199206423923954 EXTL2/FUT8/GFPT1/UGP2/UXS1 5 GO:0010092 specification of animal organ identity 5/998 36/18722 0.0407762521603674 0.199206423923954 LRP2/ISL1/GLI3/FGFR2/CTNNB1 5 GO:0014741 negative regulation of muscle hypertrophy 5/998 36/18722 0.0407762521603674 0.199206423923954 ATP2B4/P2RX4/ERRFI1/YY1/LMNA 5 GO:0051261 protein depolymerization 11/998 114/18722 0.0407875248371397 0.199206423923954 LIMA1/SCIN/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3/MICAL3 11 GO:0015804 neutral amino acid transport 6/998 48/18722 0.0411507406849913 0.20060505799845 SLC38A9/SLC43A2/SLC38A1/SLC1A5/SLC38A2/SERINC3 6 GO:0033628 regulation of cell adhesion mediated by integrin 6/998 48/18722 0.0411507406849913 0.20060505799845 DPP4/FERMT1/EFNA1/SWAP70/JAM3/PTK2 6 GO:0031330 negative regulation of cellular catabolic process 21/998 262/18722 0.0412447498033972 0.200675036271327 MET/FUS/ATP2B4/USP25/EFNA1/LRPPRC/EIF4G1/FMR1/MAPK14/DHX36/SMARCC1/BCL2/GOLGA2/SECISBP2/OPHN1/ALAD/TAB3/USP14/HNRNPU/ATRAID/ANXA2 21 GO:0006658 phosphatidylserine metabolic process 4/998 25/18722 0.0415494568491294 0.200675036271327 LPCAT3/SERINC2/PTDSS1/SERINC3 4 GO:0010842 retina layer formation 4/998 25/18722 0.0415494568491294 0.200675036271327 TFAP2A/OBSL1/AHI1/PTPRM 4 GO:0016540 protein autoprocessing 4/998 25/18722 0.0415494568491294 0.200675036271327 CTSL/PARP1/PISD/AFG3L2 4 GO:0031579 membrane raft organization 4/998 25/18722 0.0415494568491294 0.200675036271327 DLG1/CLN3/FLOT2/ANXA2 4 GO:0032331 negative regulation of chondrocyte differentiation 4/998 25/18722 0.0415494568491294 0.200675036271327 EFEMP1/TGFBR1/CTNNB1/LTBP3 4 GO:0048596 embryonic camera-type eye morphogenesis 4/998 25/18722 0.0415494568491294 0.200675036271327 BMP7/TFAP2A/FZD5/ALDH1A3 4 GO:0051450 myoblast proliferation 4/998 25/18722 0.0415494568491294 0.200675036271327 PAXBP1/MALAT1/ZNF609/MEIS2 4 GO:0090382 phagosome maturation 4/998 25/18722 0.0415494568491294 0.200675036271327 SYT7/MYO7A/CLN3/RAB31 4 GO:0140448 signaling receptor ligand precursor processing 4/998 25/18722 0.0415494568491294 0.200675036271327 MME/CTSL/ENPEP/PCSK7 4 GO:0007219 Notch signaling pathway 15/998 172/18722 0.0418202982410418 0.201376111906059 APP/GALNT11/CD46/BMP7/PERP/AAK1/YAP1/IL6ST/TP63/EPN2/NCSTN/PRKCI/SEL1L/MMP14/MAML2 15 GO:1901136 carbohydrate derivative catabolic process 15/998 172/18722 0.0418202982410418 0.201376111906059 CTSL/NUDT4/HEXB/FUCA1/MANBA/STT3B/HEXA/GM2A/EDEM3/GUSB/GNS/GPD1L/GPC1/PNP/GLB1 15 GO:0019915 lipid storage 9/998 87/18722 0.0419241395844688 0.201376111906059 ITGAV/MEST/HEXB/ABCA1/CDS1/PPARG/GM2A/HILPDA/SQLE 9 GO:0022898 regulation of transmembrane transporter activity 22/998 278/18722 0.042074265502907 0.201376111906059 APP/TCAF1/AHNAK/UTRN/AKAP9/ITGB1/GJA1/DLG1/FXYD3/ANK3/DMD/SLC9A1/HOMER1/FMR1/NEDD4/ACTN4/AHCYL1/GOPC/BCL2/ABCB1/STOM/GPD1L 22 GO:0002730 regulation of dendritic cell cytokine production 3/998 15/18722 0.04250459209356 0.201376111906059 TLR3/DHX36/DDX1 3 GO:0018146 keratan sulfate biosynthetic process 3/998 15/18722 0.04250459209356 0.201376111906059 B3GNT3/B3GNT2/B4GAT1 3 GO:0035627 ceramide transport 3/998 15/18722 0.04250459209356 0.201376111906059 PLEKHA8/ABCB1/SGPP1 3 GO:0042074 cell migration involved in gastrulation 3/998 15/18722 0.04250459209356 0.201376111906059 LRP5/AMOT/GPC3 3 GO:0045217 cell-cell junction maintenance 3/998 15/18722 0.04250459209356 0.201376111906059 FERMT2/TJP1/KIFC3 3 GO:0051127 positive regulation of actin nucleation 3/998 15/18722 0.04250459209356 0.201376111906059 SCIN/WASF2/NCKAP1 3 GO:0051938 L-glutamate import 3/998 15/18722 0.04250459209356 0.201376111906059 ITGB1/ARL6IP5/SLC1A3 3 GO:0060049 regulation of protein glycosylation 3/998 15/18722 0.04250459209356 0.201376111906059 TMEM59/GOLGA2/ARFGEF1 3 GO:0070831 basement membrane assembly 3/998 15/18722 0.04250459209356 0.201376111906059 LAMB1/DAG1/PHLDB2 3 GO:0071599 otic vesicle development 3/998 15/18722 0.04250459209356 0.201376111906059 AHI1/FGFR2/GATA3 3 GO:0098712 L-glutamate import across plasma membrane 3/998 15/18722 0.04250459209356 0.201376111906059 ITGB1/ARL6IP5/SLC1A3 3 GO:0150011 regulation of neuron projection arborization 3/998 15/18722 0.04250459209356 0.201376111906059 DVL3/MACF1/MAP3K13 3 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 3/998 15/18722 0.04250459209356 0.201376111906059 HSPA5/UFL1/PTPN1 3 GO:1902018 negative regulation of cilium assembly 3/998 15/18722 0.04250459209356 0.201376111906059 YAP1/LIMK2/MAP4 3 GO:1905288 vascular associated smooth muscle cell apoptotic process 3/998 15/18722 0.04250459209356 0.201376111906059 DNMT1/PPARG/PDCD4 3 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 3/998 15/18722 0.04250459209356 0.201376111906059 DNMT1/PPARG/PDCD4 3 GO:1990822 basic amino acid transmembrane transport 3/998 15/18722 0.04250459209356 0.201376111906059 SLC38A9/SLC7A6/SLC7A2 3 GO:0006900 vesicle budding from membrane 7/998 61/18722 0.0428185189033219 0.201919890414002 FNBP1L/SEC31A/TMED9/PRKCI/MIA3/TFG/ANXA2 7 GO:0071384 cellular response to corticosteroid stimulus 7/998 61/18722 0.0428185189033219 0.201919890414002 EGFR/ATP2B1/SERPINF1/ISL1/ERRFI1/ASS1/HNRNPU 7 GO:0090342 regulation of cell aging 7/998 61/18722 0.0428185189033219 0.201919890414002 CDK6/PRKDC/PAWR/KRAS/PLK2/LMNA/YPEL3 7 GO:0046323 glucose import 8/998 74/18722 0.0428514151654308 0.201919890414002 SLC2A1/OPN3/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 8 GO:0048332 mesoderm morphogenesis 8/998 74/18722 0.0428514151654308 0.201919890414002 ITGB4/WLS/BMP7/ITGB1/GJA1/SETD2/FGFR2/EXT2 8 GO:0070972 protein localization to endoplasmic reticulum 8/998 74/18722 0.0428514151654308 0.201919890414002 HSPA5/GJA1/RTN4/TRAM2/MIA3/SEC63/BCAP31/KDELR1 8 GO:0021537 telencephalon development 20/998 248/18722 0.0431898567341694 0.203331146987465 LAMB1/ADGRG1/SLC2A1/CDK6/NF1/LRP1/ATP2B4/TACC2/GLI3/GNG12/RTN4/RYK/TRA2B/CTNNB1/SUN1/SLC38A2/ALDH1A3/GSK3B/SECISBP2/ANXA3 20 GO:0050803 regulation of synapse structure or activity 18/998 218/18722 0.043887031293272 0.206427198542498 APP/NRP2/DAG1/DLG5/PPP1R9A/EFNA1/CDKL5/CLN3/HOMER1/EIF4G1/SEMA3F/TPBG/NEDD4/CLSTN1/VCP/MAPK14/DHX36/VPS35 18 GO:0030308 negative regulation of cell growth 16/998 188/18722 0.0439452775122696 0.206515116014005 SEMA6A/SEMA6D/NRP1/SMARCA2/GJA1/RBBP7/SPAG9/RTN4/SEMA3F/DCBLD2/RYK/VGLL4/SEMA4B/BCL2/HSPA1B/YY1 16 GO:0006643 membrane lipid metabolic process 17/998 203/18722 0.0440135781633936 0.206650082366077 DEGS1/ORMDL1/ITGB8/HACD3/PGAP1/PLPP3/HEXB/FUCA1/SERINC2/SPTLC3/HEXA/GM2A/SGPP1/SERINC3/SUMF1/TECR/GLB1 17 GO:0072594 establishment of protein localization to organelle 31/998 422/18722 0.0445545487212257 0.20900206547486 CDH1/LMAN1/HSPA5/PTTG1IP/HSPD1/FERMT1/GLI3/TNPO1/TPR/HUWE1/LEPROT/VPS13A/NEDD4/TRAM2/NPEPPS/SEC63/HSP90AA1/BCAP31/MAPK14/GNPTAB/GCC2/FZD5/RANBP17/IPO7/RANBP2/UBR5/NIPBL/ZFYVE16/PPP1R10/LMNA/TOMM20 31 GO:0018198 peptidyl-cysteine modification 6/998 49/18722 0.0448650570093259 0.209517408448739 ATP2B4/DMD/RAB6A/ZDHHC17/ADH5/OXR1 6 GO:0035088 establishment or maintenance of apical/basal cell polarity 6/998 49/18722 0.0448650570093259 0.209517408448739 DLG5/DLG1/FAT1/PRKCI/PARD3/OPHN1 6 GO:0038084 vascular endothelial growth factor signaling pathway 6/998 49/18722 0.0448650570093259 0.209517408448739 NRP2/SEMA6A/NRP1/GAB1/PIK3CB/MYO1C 6 GO:0061245 establishment or maintenance of bipolar cell polarity 6/998 49/18722 0.0448650570093259 0.209517408448739 DLG5/DLG1/FAT1/PRKCI/PARD3/OPHN1 6 GO:0070169 positive regulation of biomineral tissue development 6/998 49/18722 0.0448650570093259 0.209517408448739 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ATRAID 6 GO:0003161 cardiac conduction system development 5/998 37/18722 0.0451584093000177 0.209575159960349 GJA1/GJA5/DSG2/ISL1/MSX2 5 GO:0006623 protein targeting to vacuole 5/998 37/18722 0.0451584093000177 0.209575159960349 VPS13A/NEDD4/GNPTAB/GCC2/ZFYVE16 5 GO:0006862 nucleotide transport 5/998 37/18722 0.0451584093000177 0.209575159960349 GJA1/CD47/SLC19A1/SLC25A36/SLC29A1 5 GO:0031112 positive regulation of microtubule polymerization or depolymerization 5/998 37/18722 0.0451584093000177 0.209575159960349 MET/CLIP1/AKAP9/OCLN/HSPA1B 5 GO:0045616 regulation of keratinocyte differentiation 5/998 37/18722 0.0451584093000177 0.209575159960349 NCOA3/TP63/ERRFI1/GRHL1/SGPP1 5 GO:0051567 histone H3-K9 methylation 5/998 37/18722 0.0451584093000177 0.209575159960349 DNMT1/ASH1L/ATRX/RIF1/LMNA 5 GO:1905332 positive regulation of morphogenesis of an epithelium 5/998 37/18722 0.0451584093000177 0.209575159960349 MAGED1/GJA1/LGR4/CTNNB1/GATA3 5 GO:0014897 striated muscle hypertrophy 10/998 102/18722 0.0453205679464333 0.210140928284483 PARP1/ATP2B4/IL6ST/SLC9A1/P2RX4/ERRFI1/ATP2A2/HDAC2/YY1/LMNA 10 GO:0048639 positive regulation of developmental growth 15/998 174/18722 0.0455081336617218 0.210721826603143 NRP1/GOLGA4/LRP1/TGFBR3/YAP1/PRKDC/CDKL5/MACF1/EZR/MAPK14/FGFR2/BCL2/NIPBL/MAP3K13/PPIB 15 GO:0034764 positive regulation of transmembrane transport 18/998 219/18722 0.0455440089405549 0.210721826603143 TCAF1/AKAP9/ITGB1/ANO6/ANK3/OPN3/KCNN4/DMD/SLC9A1/PRKCI/ACTN4/SORBS1/MAPK14/AZIN1/ABCB1/OCLN/GPC3/NFE2L2 18 GO:0051052 regulation of DNA metabolic process 27/998 359/18722 0.0456072905691537 0.210721826603143 EGFR/TFRC/GJA1/PARP1/FUS/PRKDC/RAD50/ATRX/MAP3K4/USP9X/DCP2/PKIB/MPHOSPH8/SETD2/HSP90AA1/RIF1/CTNNB1/DHX36/TNKS2/GATA3/UBR5/OTUD4/YLPM1/PPP1R10/ANXA3/HNRNPU/HNRNPA2B1 27 GO:0071900 regulation of protein serine/threonine kinase activity 27/998 359/18722 0.0456072905691537 0.210721826603143 EGFR/MAGED1/BMP7/NR2F2/NF1/LRP5/CD24/ATP2B4/DVL3/MAP3K4/CCND1/FERMT2/ERP29/PKIB/LATS2/PTPN1/PPARG/PIK3CB/KRAS/UVRAG/CDKN1C/FZD5/IPO7/PDCD4/CDK7/HEXIM1/MAP3K13 27 GO:0006278 RNA-dependent DNA biosynthetic process 8/998 75/18722 0.0458260348670973 0.211171869409634 RAD50/MAP3K4/DCP2/PKIB/HSP90AA1/CTNNB1/TNKS2/HNRNPU 8 GO:0008088 axo-dendritic transport 8/998 75/18722 0.0458260348670973 0.211171869409634 APP/DST/DYNC1H1/SFPQ/PURA/FLOT2/ARMCX3/HNRNPU 8 GO:1903363 negative regulation of cellular protein catabolic process 8/998 75/18722 0.0458260348670973 0.211171869409634 USP25/EFNA1/SMARCC1/OPHN1/ALAD/USP14/ATRAID/ANXA2 8 GO:0009311 oligosaccharide metabolic process 7/998 62/18722 0.046143527832405 0.212447406360658 FUT8/HEXB/MANBA/B4GALT1/GM2A/MOGS/GAA 7 GO:0045930 negative regulation of mitotic cell cycle 19/998 235/18722 0.0468241712027204 0.215391187532514 EGFR/BMP7/DLG1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/TPR/CCND1/WEE1/BRD7/RAD21/CDKN1C/CTNNB1/BCL2/PLK2/XPC/PPP1R10 19 GO:0018205 peptidyl-lysine modification 28/998 376/18722 0.0470218404699366 0.215451500070729 NCOA3/BRD4/TGM2/DNMT1/ZNF451/CBX4/MDM2/ASH1L/ISL1/ATRX/TET2/RPS6KA5/SMYD2/SETD2/SUZ12/NSD1/BRD7/RIF1/CTNNB1/PHF20/KMT2C/RANBP2/GATA3/USP22/BRD8/KIAA1586/HDAC2/LMNA 28 GO:0001573 ganglioside metabolic process 4/998 26/18722 0.0471048644582767 0.215451500070729 ITGB8/HEXB/HEXA/GM2A 4 GO:0006027 glycosaminoglycan catabolic process 4/998 26/18722 0.0471048644582767 0.215451500070729 FUCA1/GUSB/GNS/GLB1 4 GO:0033598 mammary gland epithelial cell proliferation 4/998 26/18722 0.0471048644582767 0.215451500070729 KDM5B/CCND1/RTN4/GATA3 4 GO:0097066 response to thyroid hormone 4/998 26/18722 0.0471048644582767 0.215451500070729 CTSL/RDX/BRD8/ANXA2 4 GO:1904353 regulation of telomere capping 4/998 26/18722 0.0471048644582767 0.215451500070729 RAD50/MAP3K4/PKIB/TNKS2 4 GO:0019079 viral genome replication 12/998 131/18722 0.0471261469221935 0.215451500070729 DDB1/HACD3/EEA1/MPHOSPH8/FMR1/TOP2B/PKN2/EIF2AK4/VCP/BCL2/STOM/PPIB 12 GO:0031503 protein-containing complex localization 18/998 220/18722 0.0472452885911176 0.215807219365026 DAG1/AKAP9/DLG1/TPR/SFPQ/EZR/SETD2/CLSTN1/PURA/PCM1/OPHN1/LSG1/VPS35/AGFG1/PABPN1/NSG1/HNRNPU/HNRNPA2B1 18 GO:0050773 regulation of dendrite development 10/998 103/18722 0.0479064299092528 0.218635900835847 BMP7/CUX1/OBSL1/COBL/CDKL5/NEDD4/CAMSAP2/TMEM106B/DHX36/GSK3B 10 GO:0045814 negative regulation of gene expression, epigenetic 6/998 50/18722 0.0487817092972642 0.222048216426344 DNMT1/DNMT3A/TPR/MPHOSPH8/SMARCA5/CREBZF 6 GO:0060425 lung morphogenesis 6/998 50/18722 0.0487817092972642 0.222048216426344 DAG1/DLG5/YAP1/KRAS/FGFR2/CTNNB1 6 GO:0110151 positive regulation of biomineralization 6/998 50/18722 0.0487817092972642 0.222048216426344 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ATRAID 6 GO:0006605 protein targeting 24/998 314/18722 0.0489263261748041 0.222347716275123 TCAF1/LMAN1/HSPA5/ANK3/SIL1/HSPD1/HUWE1/LEPROT/VPS13A/PRKCI/NEDD4/PARD3/TRAM2/NPEPPS/SEC63/HSP90AA1/BCAP31/GNPTAB/GCC2/FZD5/MYO1C/STOM/ZFYVE16/TOMM20 24 GO:0014855 striated muscle cell proliferation 8/998 76/18722 0.0489326807125294 0.222347716275123 GJA1/TGFBR3/YAP1/TGFBR1/PAXBP1/MAPK14/FGFR2/VGLL4 8 GO:0090257 regulation of muscle system process 20/998 252/18722 0.0495276857478597 0.223311187064636 DSP/ATP2B1/DSC2/DAG1/AKAP9/DLG1/GJA5/DSG2/PARP1/ATP2B4/IL6ST/CAMK2G/DMD/SLC9A1/P2RX4/ERRFI1/PKP2/ATP2A2/YY1/LMNA 20 GO:0022617 extracellular matrix disassembly 7/998 63/18722 0.0496292824369966 0.223311187064636 LAMC1/DPP4/LRP1/CTSV/MMP15/MMP14/DDR1 7 GO:0032373 positive regulation of sterol transport 5/998 38/18722 0.0498106219681659 0.223311187064636 LRP1/ABCA1/LPCAT3/PPARG/ANXA2 5 GO:0032376 positive regulation of cholesterol transport 5/998 38/18722 0.0498106219681659 0.223311187064636 LRP1/ABCA1/LPCAT3/PPARG/ANXA2 5 GO:0035136 forelimb morphogenesis 5/998 38/18722 0.0498106219681659 0.223311187064636 TFAP2A/ATRX/TP63/CTNNB1/NIPBL 5 GO:0042491 inner ear auditory receptor cell differentiation 5/998 38/18722 0.0498106219681659 0.223311187064636 MCOLN3/MYO7A/ESRP1/TRIOBP/MYO6 5 GO:0042596 fear response 5/998 38/18722 0.0498106219681659 0.223311187064636 ADRB1/DPP4/GJA1/EIF4G1/BCL2 5 GO:1901031 regulation of response to reactive oxygen species 5/998 38/18722 0.0498106219681659 0.223311187064636 MET/BMP7/STK26/PAWR/NFE2L2 5 GO:0034219 carbohydrate transmembrane transport 11/998 118/18722 0.0502475423740639 0.223311187064636 SLC2A1/SLC5A3/OPN3/YES1/PRKCI/SORBS1/MAPK14/SLC17A5/OCLN/GPC3/NFE2L2 11 GO:0045446 endothelial cell differentiation 11/998 118/18722 0.0502475423740639 0.223311187064636 MET/NRP1/NR2F2/FSTL1/TJP1/S1PR2/EZR/CTNNB1/RDX/FASN/MARVELD2 11 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 9/998 90/18722 0.0502559297342157 0.223311187064636 MDM2/RNF217/HECTD1/BCAP31/VCP/PLK2/HSPA1B/GSK3B/NFE2L2 9 GO:0001845 phagolysosome assembly 3/998 16/18722 0.0502995510415653 0.223311187064636 SYT7/MYO7A/CLN3 3 GO:0002371 dendritic cell cytokine production 3/998 16/18722 0.0502995510415653 0.223311187064636 TLR3/DHX36/DDX1 3 GO:0002921 negative regulation of humoral immune response 3/998 16/18722 0.0502995510415653 0.223311187064636 CD46/CD55/CD59 3 GO:0010225 response to UV-C 3/998 16/18722 0.0502995510415653 0.223311187064636 MDM2/MAP3K4/YY1 3 GO:0010649 regulation of cell communication by electrical coupling 3/998 16/18722 0.0502995510415653 0.223311187064636 GJA1/GJA5/ANK3 3 GO:0019081 viral translation 3/998 16/18722 0.0502995510415653 0.223311187064636 EIF3A/EIF2AK4/DENR 3 GO:0021535 cell migration in hindbrain 3/998 16/18722 0.0502995510415653 0.223311187064636 ITGB1/RERE/RBFOX2 3 GO:0030033 microvillus assembly 3/998 16/18722 0.0502995510415653 0.223311187064636 KLF5/STK26/EZR 3 GO:0035751 regulation of lysosomal lumen pH 3/998 16/18722 0.0502995510415653 0.223311187064636 CLN3/TMEM106B/TMEM165 3 GO:0042795 snRNA transcription by RNA polymerase II 3/998 16/18722 0.0502995510415653 0.223311187064636 ICE1/CDK7/ELL 3 GO:0048557 embryonic digestive tract morphogenesis 3/998 16/18722 0.0502995510415653 0.223311187064636 GLI3/FGFR2/NIPBL 3 GO:0072148 epithelial cell fate commitment 3/998 16/18722 0.0502995510415653 0.223311187064636 NRP1/NR2F2/ESRP1 3 GO:0090336 positive regulation of brown fat cell differentiation 3/998 16/18722 0.0502995510415653 0.223311187064636 BMP7/MAPK14/HNRNPU 3 GO:0090520 sphingolipid mediated signaling pathway 3/998 16/18722 0.0502995510415653 0.223311187064636 S1PR2/EZR/PIK3CB 3 GO:1901163 regulation of trophoblast cell migration 3/998 16/18722 0.0502995510415653 0.223311187064636 GJA1/CALR/AGO2 3 GO:2001224 positive regulation of neuron migration 3/998 16/18722 0.0502995510415653 0.223311187064636 SEMA6A/ZNF609/NIPBL 3 GO:0001894 tissue homeostasis 21/998 268/18722 0.0503632524696006 0.223404028159545 EGFR/SLC2A1/LAMC1/TFRC/ITGB1/GJA1/NF1/GCNT2/YAP1/DMD/HOMER1/TJP1/LSR/P2RX4/KRAS/JAM3/SLC22A5/CTNNB1/BCL2/OCLN/LTBP3 21 GO:1902652 secondary alcohol metabolic process 13/998 147/18722 0.0505432922594813 0.224012333520163 APP/LRP5/IDH1/LIMA1/ABCA1/LPCAT3/ACADVL/MBTPS1/DHCR24/NFE2L1/FDFT1/HDLBP/SQLE 13 GO:0014896 muscle hypertrophy 10/998 104/18722 0.0505895202913304 0.22402704447925 PARP1/ATP2B4/IL6ST/SLC9A1/P2RX4/ERRFI1/ATP2A2/HDAC2/YY1/LMNA 10 GO:0051098 regulation of binding 27/998 363/18722 0.051000460545087 0.225655427547372 APP/MET/NRP1/LRPAP1/LRP1/PARP1/TGFBR3/ISL1/EIF4G1/FMR1/TGFBR1/MSX2/NSD1/PPARG/CTNNB1/TCF7L2/WAPL/GATA3/GOLGA2/PLK2/AKTIP/ATP2A2/SPPL3/GSK3B/HDAC2/PHLDA2/ANXA2 27 GO:0043405 regulation of MAP kinase activity 15/998 177/18722 0.0514606989397724 0.227306522135831 EGFR/MAGED1/BMP7/NF1/CD24/DVL3/MAP3K4/ERP29/PTPN1/PPARG/PIK3CB/KRAS/FZD5/PDCD4/MAP3K13 15 GO:0071453 cellular response to oxygen levels 15/998 177/18722 0.0514606989397724 0.227306522135831 BMP7/P4HB/MDM2/DNMT3A/SLC9A1/NPEPPS/HP1BP3/MALAT1/BCL2/STC2/HILPDA/PMAIP1/LMNA/SLC29A1/NFE2L2 15 GO:0010595 positive regulation of endothelial cell migration 12/998 133/18722 0.0518347890488553 0.228765370772674 MET/NRP2/NRP1/CALR/PLPP3/P2RX4/PIK3CB/GATA3/PLK2/EMC10/ANXA3/NFE2L2 12 GO:0010827 regulation of glucose transmembrane transport 8/998 77/18722 0.0521728140958932 0.229674757499712 OPN3/YES1/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 8 GO:0031016 pancreas development 8/998 77/18722 0.0521728140958932 0.229674757499712 MET/WLS/CDK6/ISL1/CTNNB1/TCF7L2/GSK3B/MEIS2 8 GO:0048644 muscle organ morphogenesis 8/998 77/18722 0.0521728140958932 0.229674757499712 LRP2/DSP/TGFBR3/ISL1/TGFBR1/FGFR2/ARID5B/PKP2 8 GO:0032259 methylation 27/998 364/18722 0.0524182108158237 0.230560639148623 BRD4/DNMT1/PARP1/METTL7A/MTR/ASH1L/DNMT3A/ZC3H13/ATRX/TET2/SMYD2/RAB6A/MPHOSPH8/SETD2/SUZ12/NSD1/PAXBP1/TARBP1/RIF1/CTNNB1/KMT2C/GATA3/CMTR1/PRDM2/PCMTD1/PCMTD2/LMNA 27 GO:0030282 bone mineralization 11/998 119/18722 0.0528257475241546 0.231008582617981 FBN2/ATP2B1/BMP7/LGR4/ANO6/TFAP2A/ANKH/FGFR2/LTBP3/GPC3/ATRAID 11 GO:0010212 response to ionizing radiation 13/998 148/18722 0.0528358059727662 0.231008582617981 HSPA5/PARP1/YAP1/PRKDC/NET1/MDM2/DNMT3A/CCND1/MAPK14/GATA3/BCL2/NIPBL/ALAD 13 GO:0044272 sulfur compound biosynthetic process 13/998 148/18722 0.0528358059727662 0.231008582617981 SLC26A2/ACSS1/CHPF/MTR/B3GNT3/GLCE/CDO1/B3GNT2/EXT2/ACSL3/B4GAT1/TECR/NFE2L2 13 GO:0045104 intermediate filament cytoskeleton organization 6/998 51/18722 0.052902342238492 0.231008582617981 DSP/DST/MACF1/PKP2/PLEC/KRT18 6 GO:0046850 regulation of bone remodeling 6/998 51/18722 0.052902342238492 0.231008582617981 EGFR/TFRC/NF1/SUCO/SYT7/LTBP3 6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 4/998 27/18722 0.0530510037462093 0.231008582617981 CD47/VAV3/YES1/PTK2 4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 4/998 27/18722 0.0530510037462093 0.231008582617981 APP/BRD4/PBX1/CCND1 4 GO:0032786 positive regulation of DNA-templated transcription, elongation 4/998 27/18722 0.0530510037462093 0.231008582617981 BRD4/CTNNB1/TCERG1/ELL 4 GO:0034453 microtubule anchoring 4/998 27/18722 0.0530510037462093 0.231008582617981 DAG1/PCM1/GCC2/GSK3B 4 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 4/998 27/18722 0.0530510037462093 0.231008582617981 CD47/VAV3/YES1/PTK2 4 GO:1903205 regulation of hydrogen peroxide-induced cell death 4/998 27/18722 0.0530510037462093 0.231008582617981 MET/STK26/PAWR/NFE2L2 4 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 4/998 27/18722 0.0530510037462093 0.231008582617981 PARP1/DCP2/TNKS2/HNRNPU 4 GO:1901215 negative regulation of neuron death 17/998 208/18722 0.0531275040215236 0.231148915413645 NRP1/RASA1/SERPINF1/LRP1/HSPD1/ERBB3/ISL1/CLN3/EIF4G1/PRKCI/KRAS/CTNNB1/BCL2/GSK3B/OXR1/VPS35/TMEM259 17 GO:0002065 columnar/cuboidal epithelial cell differentiation 9/998 91/18722 0.0532585949665505 0.231222764278115 CDK6/YAP1/IL6ST/KLF5/TP63/FGFR2/YIPF6/GSK3B/FASN 9 GO:0001885 endothelial cell development 7/998 64/18722 0.0532773387141491 0.231222764278115 MET/TJP1/S1PR2/EZR/RDX/FASN/MARVELD2 7 GO:0050771 negative regulation of axonogenesis 7/998 64/18722 0.0532773387141491 0.231222764278115 SEMA6A/SEMA6D/NRP1/RTN4/SEMA3F/RYK/SEMA4B 7 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 10/998 105/18722 0.0533709258792145 0.231436548185531 NRP1/FNBP1L/ATMIN/COBL/WASF2/FMR1/TGFBR1/NCKAP1/EPS8/OCLN 10 GO:0030099 myeloid cell differentiation 28/998 381/18722 0.0538203480185332 0.233191731954159 FBN1/APP/CSF3R/ITGB8/TFRC/CDK6/PARP1/TGFBR3/PRKDC/SCIN/RCOR1/EIF2AK1/TET2/TLR3/WASF2/UFL1/PPARG/MAPK14/CTNNB1/GATA3/RBFOX2/HSPA1B/MEIS2/FASN/PURB/GPC3/HSPA9/ANXA2 28 GO:0043547 positive regulation of GTPase activity 20/998 255/18722 0.0546983533930517 0.236364964537187 ITGA6/RASA1/ADRB1/ITGB1/NF1/TGM2/DOCK9/NET1/DVL3/PLXNB1/CDKL5/CCDC125/SYDE2/FERMT2/DOCK8/SNX13/CHN2/NEDD9/GSK3B/EVI5 20 GO:0016233 telomere capping 5/998 39/18722 0.0547338138527981 0.236364964537187 PRKDC/RAD50/MAP3K4/PKIB/TNKS2 5 GO:0031507 heterochromatin assembly 5/998 39/18722 0.0547338138527981 0.236364964537187 DNMT1/DNMT3A/TPR/MPHOSPH8/SMARCA5 5 GO:0051084 'de novo' posttranslational protein folding 5/998 39/18722 0.0547338138527981 0.236364964537187 HSPA5/DNAJB14/DNAJB4/HSPA1B/HSPA9 5 GO:1902905 positive regulation of supramolecular fiber organization 17/998 209/18722 0.0550976212141369 0.237739405255379 APP/MET/NRP1/CLIP1/AKAP9/DLG1/IQGAP2/CD47/SCIN/WASF2/FERMT2/TGFBR1/SWAP70/MYO1C/NCKAP1/OCLN/HSPA1B 17 GO:0030500 regulation of bone mineralization 8/998 78/18722 0.0555477140890076 0.239285986187053 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ANKH/LTBP3/ATRAID 8 GO:0070373 negative regulation of ERK1 and ERK2 cascade 8/998 78/18722 0.0555477140890076 0.239285986187053 SEMA6A/FBLN1/DLG1/EIF3A/DUSP9/EZR/PTPN1/ERRFI1 8 GO:0022407 regulation of cell-cell adhesion 32/998 448/18722 0.057021169786794 0.244707721776413 CDH1/CD46/TENM3/BMP7/DPP4/TFRC/NFAT5/DLG5/SPINT2/DLG1/CD55/ANK3/CD24/GCNT2/CD47/PLPP3/IL6ST/HSPD1/GLI3/DOCK8/TJP1/PAWR/YES1/SWAP70/MIA3/MAPK14/RDX/PTK2/GATA3/ASS1/FLOT2/PNP 32 GO:0033692 cellular polysaccharide biosynthetic process 7/998 65/18722 0.0570889730467467 0.244707721776413 AGL/UGP2/B3GNT3/SORBS1/B3GNT2/EXT2/GSK3B 7 GO:0038034 signal transduction in absence of ligand 7/998 65/18722 0.0570889730467467 0.244707721776413 ITGAV/IFI6/ERBB3/BCL2/HSPA1B/GSK3B/CTNNA1 7 GO:0048524 positive regulation of viral process 7/998 65/18722 0.0570889730467467 0.244707721776413 DDB1/HACD3/P4HB/FMR1/TOP2B/PKN2/STOM 7 GO:0070613 regulation of protein processing 7/998 65/18722 0.0570889730467467 0.244707721776413 GLG1/MDM2/LPCAT3/CLN3/TMEM59/CAST/MMP14 7 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 7/998 65/18722 0.0570889730467467 0.244707721776413 ITGAV/IFI6/ERBB3/BCL2/HSPA1B/GSK3B/CTNNA1 7 GO:0035196 production of miRNAs involved in gene silencing by miRNA 6/998 52/18722 0.0572281417906531 0.244707721776413 EGFR/LIN28B/PUM1/DICER1/AGO2/HNRNPA2B1 6 GO:0045103 intermediate filament-based process 6/998 52/18722 0.0572281417906531 0.244707721776413 DSP/DST/MACF1/PKP2/PLEC/KRT18 6 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 6/998 52/18722 0.0572281417906531 0.244707721776413 ZNRF3/DVL3/RYK/FZD6/DAAM1/GPC3 6 GO:0015698 inorganic anion transport 15/998 180/18722 0.057933550916816 0.245290921192928 SLC26A2/SLC13A4/GABRE/CLDN4/FXYD3/ANO6/SLC22A11/PCYOX1/ANKH/SLC12A9/SLC1A3/SLC5A6/GABRA4/SLC20A2/ABCB1 15 GO:0071772 response to BMP 14/998 165/18722 0.0579584054638142 0.245290921192928 FBN1/LRP2/SPINT1/CRIM1/BMP7/SPINT2/TGFBR3/TRIM33/FSTL1/USP9X/PPARG/GATA3/PDCD4/GPC3 14 GO:0071773 cellular response to BMP stimulus 14/998 165/18722 0.0579584054638142 0.245290921192928 FBN1/LRP2/SPINT1/CRIM1/BMP7/SPINT2/TGFBR3/TRIM33/FSTL1/USP9X/PPARG/GATA3/PDCD4/GPC3 14 GO:0042177 negative regulation of protein catabolic process 11/998 121/18722 0.0582445752468254 0.245290921192928 EGFR/USP25/EFNA1/MYCBP2/AZIN1/SMARCC1/OPHN1/ALAD/USP14/ATRAID/ANXA2 11 GO:0043500 muscle adaptation 11/998 121/18722 0.0582445752468254 0.245290921192928 DAG1/PARP1/ATP2B4/IL6ST/CAMK2G/SLC9A1/P2RX4/ERRFI1/ATP2A2/YY1/LMNA 11 GO:0009895 negative regulation of catabolic process 24/998 320/18722 0.0583087003580231 0.245290921192928 EGFR/MET/FUS/ATP2B4/USP25/EFNA1/LRPPRC/EIF4G1/MYCBP2/FMR1/MAPK14/DHX36/AZIN1/SMARCC1/BCL2/GOLGA2/SECISBP2/OPHN1/ALAD/TAB3/USP14/HNRNPU/ATRAID/ANXA2 24 GO:0071496 cellular response to external stimulus 24/998 320/18722 0.0583087003580231 0.245290921192928 EGFR/SLC2A1/ATP2B1/DAG1/HSPA5/GJA1/TMEM150C/CTSV/SKP2/MDM2/FOLR1/TLR3/SLC9A1/STK26/GABARAPL1/EIF4G1/EIF2AK4/TRIM24/SLC38A2/BCL2/PLEC/TNRC6A/PMAIP1/NFE2L2 24 GO:0051495 positive regulation of cytoskeleton organization 18/998 226/18722 0.0584108524209803 0.245290921192928 MET/NRP1/CLIP1/AKAP9/DLG1/IQGAP2/CD47/DYNC1H1/SCIN/WASF2/FERMT2/TGFBR1/SWAP70/MYO1C/NCKAP1/OCLN/HSPA1B/GPSM2 18 GO:0006577 amino-acid betaine metabolic process 3/998 17/18722 0.0587342178667625 0.245290921192928 ALDH7A1/CROT/CPT2 3 GO:0009084 glutamine family amino acid biosynthetic process 3/998 17/18722 0.0587342178667625 0.245290921192928 CLN3/ALDH18A1/ASS1 3 GO:0010224 response to UV-B 3/998 17/18722 0.0587342178667625 0.245290921192928 MME/BCL2/XPC 3 GO:0010612 regulation of cardiac muscle adaptation 3/998 17/18722 0.0587342178667625 0.245290921192928 ATP2B4/ERRFI1/LMNA 3 GO:0010715 regulation of extracellular matrix disassembly 3/998 17/18722 0.0587342178667625 0.245290921192928 DPP4/LRP1/DDR1 3 GO:0016264 gap junction assembly 3/998 17/18722 0.0587342178667625 0.245290921192928 GJA1/GJA5/CTNNA1 3 GO:0030903 notochord development 3/998 17/18722 0.0587342178667625 0.245290921192928 YAP1/EFNA1/COBL 3 GO:0031445 regulation of heterochromatin assembly 3/998 17/18722 0.0587342178667625 0.245290921192928 DNMT1/TPR/MPHOSPH8 3 GO:0033623 regulation of integrin activation 3/998 17/18722 0.0587342178667625 0.245290921192928 FERMT1/FERMT2/JAM3 3 GO:0044539 long-chain fatty acid import into cell 3/998 17/18722 0.0587342178667625 0.245290921192928 SLC2A1/SLC27A2/ACSL3 3 GO:0071816 tail-anchored membrane protein insertion into ER membrane 3/998 17/18722 0.0587342178667625 0.245290921192928 EMC1/EMC10/EMC7 3 GO:0097067 cellular response to thyroid hormone stimulus 3/998 17/18722 0.0587342178667625 0.245290921192928 CTSL/RDX/BRD8 3 GO:0120261 regulation of heterochromatin organization 3/998 17/18722 0.0587342178667625 0.245290921192928 DNMT1/TPR/MPHOSPH8 3 GO:0140354 lipid import into cell 3/998 17/18722 0.0587342178667625 0.245290921192928 SLC2A1/SLC27A2/ACSL3 3 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 3/998 17/18722 0.0587342178667625 0.245290921192928 ATP2B4/ERRFI1/LMNA 3 GO:1903358 regulation of Golgi organization 3/998 17/18722 0.0587342178667625 0.245290921192928 AKAP9/PDE4DIP/CAMSAP2 3 GO:1904355 positive regulation of telomere capping 3/998 17/18722 0.0587342178667625 0.245290921192928 MAP3K4/PKIB/TNKS2 3 GO:0006029 proteoglycan metabolic process 8/998 79/18722 0.0590584744811427 0.245290921192928 EXTL2/CHPF/HS6ST2/GLCE/CTNNB1/TCF7L2/EXT2/GPC1 8 GO:0050772 positive regulation of axonogenesis 8/998 79/18722 0.0590584744811427 0.245290921192928 NRP1/GOLGA4/LRP1/PLXNB1/CDKL5/MACF1/PLXNA1/MAP3K13 8 GO:0010927 cellular component assembly involved in morphogenesis 10/998 107/18722 0.0592325672002867 0.245290921192928 ITGB4/DAG1/ITGB1/OBSL1/EPB41L3/DICER1/PLEC/PHLDB2/TMF1/GPC1 10 GO:0071868 cellular response to monoamine stimulus 10/998 107/18722 0.0592325672002867 0.245290921192928 APP/TGM2/ATP2B4/SLC9A1/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 10 GO:0071870 cellular response to catecholamine stimulus 10/998 107/18722 0.0592325672002867 0.245290921192928 APP/TGM2/ATP2B4/SLC9A1/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 10 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 10/998 107/18722 0.0592325672002867 0.245290921192928 MDM2/RNF217/HECTD1/BCAP31/VCP/PTK2/PLK2/HSPA1B/GSK3B/NFE2L2 10 GO:0001945 lymph vessel development 4/998 28/18722 0.0593847393962577 0.245290921192928 SVEP1/NR2F2/PTPN14/LGALS8 4 GO:0006829 zinc ion transport 4/998 28/18722 0.0593847393962577 0.245290921192928 SLC39A10/SLC39A7/SLC39A1/SLC30A7 4 GO:0007064 mitotic sister chromatid cohesion 4/998 28/18722 0.0593847393962577 0.245290921192928 ATRX/RAD21/PDS5A/NIPBL 4 GO:0010464 regulation of mesenchymal cell proliferation 4/998 28/18722 0.0593847393962577 0.245290921192928 LRP5/FGFR2/CTNNB1/LMNA 4 GO:0019098 reproductive behavior 4/998 28/18722 0.0593847393962577 0.245290921192928 APP/ZFX/HEXB/HDAC2 4 GO:0032607 interferon-alpha production 4/998 28/18722 0.0593847393962577 0.245290921192928 HSPD1/TLR3/SETD2/DHX36 4 GO:0032647 regulation of interferon-alpha production 4/998 28/18722 0.0593847393962577 0.245290921192928 HSPD1/TLR3/SETD2/DHX36 4 GO:0038094 Fc-gamma receptor signaling pathway 4/998 28/18722 0.0593847393962577 0.245290921192928 CD47/VAV3/YES1/PTK2 4 GO:0051503 adenine nucleotide transport 4/998 28/18722 0.0593847393962577 0.245290921192928 GJA1/CD47/SLC19A1/SLC29A1 4 GO:0060325 face morphogenesis 4/998 28/18722 0.0593847393962577 0.245290921192928 ANKRD11/ARID5B/PLEKHA1/NIPBL 4 GO:0080111 DNA demethylation 4/998 28/18722 0.0593847393962577 0.245290921192928 TET2/USP9X/GATA3/OTUD4 4 GO:1903779 regulation of cardiac conduction 4/998 28/18722 0.0593847393962577 0.245290921192928 ATP2B1/GJA5/ATP2B4/ATP2A2 4 GO:0090398 cellular senescence 9/998 93/18722 0.0596088815643778 0.245633757417219 CDK6/CALR/PRKDC/PAWR/PLA2R1/KRAS/MAPK14/PLK2/YPEL3 9 GO:0097306 cellular response to alcohol 9/998 93/18722 0.0596088815643778 0.245633757417219 CDH1/ATP2B1/DAG1/MDM2/ABCA1/DNMT3A/CTNNB1/GNAI1/CTNNA1 9 GO:1902807 negative regulation of cell cycle G1/S phase transition 9/998 93/18722 0.0596088815643778 0.245633757417219 DLG1/PRKDC/CTDSPL/MDM2/CCND1/WEE1/BRD7/BCL2/PLK2 9 GO:0045022 early endosome to late endosome transport 5/998 40/18722 0.0599280841414895 0.246559911192054 EEA1/HOOK2/EZR/RDX/AKTIP 5 GO:0097352 autophagosome maturation 5/998 40/18722 0.0599280841414895 0.246559911192054 CLN3/UVRAG/VCP/ATP2A2/SNX14 5 GO:0030902 hindbrain development 13/998 151/18722 0.0601359278530202 0.247220219937495 WLS/BMP7/SLC6A4/HSPA5/ITGB1/RERE/AHI1/NCSTN/CTNNB1/BCL2/SDF4/RBFOX2/OPHN1 13 GO:0033674 positive regulation of kinase activity 33/998 467/18722 0.0607257488473534 0.249448571779726 EGFR/MET/DAG1/MAGED1/LMO4/DLG1/IGF1R/CD24/PRLR/EPHB4/ATP2B4/VAV3/DVL3/ERBB3/PPP1R9A/RAD50/EFNA1/MAP3K4/TLR3/CCND1/FERMT2/ERP29/PTPN1/HSP90AA1/KRAS/RYK/FGFR2/FZD5/RANBP2/DDR1/NEDD9/PTK2/MAP3K13 33 GO:0050922 negative regulation of chemotaxis 7/998 66/18722 0.0610651800847544 0.250252201901494 SEMA6A/SEMA6D/NRP1/DPP4/SEMA3F/RYK/SEMA4B 7 GO:0071300 cellular response to retinoic acid 7/998 66/18722 0.0610651800847544 0.250252201901494 SLC6A4/SERPINF1/YAP1/ABCA1/YES1/FGFR2/HDAC2 7 GO:1902476 chloride transmembrane transport 7/998 66/18722 0.0610651800847544 0.250252201901494 SLC26A2/GABRE/ANO6/PCYOX1/SLC12A9/SLC1A3/GABRA4 7 GO:0016925 protein sumoylation 6/998 53/18722 0.0617598369588274 0.252306814367792 ZNF451/CBX4/MDM2/CTNNB1/RANBP2/KIAA1586 6 GO:0032210 regulation of telomere maintenance via telomerase 6/998 53/18722 0.0617598369588274 0.252306814367792 MAP3K4/DCP2/PKIB/CTNNB1/TNKS2/HNRNPU 6 GO:0043620 regulation of DNA-templated transcription in response to stress 6/998 53/18722 0.0617598369588274 0.252306814367792 HSPA5/BCLAF1/NEDD4/ATF6/CHD6/NFE2L2 6 GO:2000772 regulation of cellular senescence 6/998 53/18722 0.0617598369588274 0.252306814367792 CDK6/PRKDC/PAWR/KRAS/PLK2/YPEL3 6 GO:0071248 cellular response to metal ion 16/998 197/18722 0.0620300472185593 0.253212569607582 EGFR/APP/CDH1/SERPINF1/HSPA5/ANK3/PARP1/CALR/FUS/TFAP2A/SYT7/HSD17B1/NCSTN/P2RX4/ALAD/NFE2L2 16 GO:0008203 cholesterol metabolic process 12/998 137/18722 0.062186426049028 0.253652601876543 APP/LRP5/LIMA1/ABCA1/LPCAT3/ACADVL/MBTPS1/DHCR24/NFE2L1/FDFT1/HDLBP/SQLE 12 GO:0003012 muscle system process 32/998 452/18722 0.0627018685166377 0.255049042042389 DSP/ATP2B1/DSC2/DAG1/ASPH/UTRN/AKAP9/GJA1/DLG1/GJA5/DSG2/PARP1/MYOF/ATP2B4/IL6ST/CAMK2G/DMD/CALD1/SLC9A1/HOMER1/SSPN/P2RX4/ERRFI1/PKP2/GAA/PPP1R13L/ATP2A2/GPD1L/HDAC2/YY1/LMNA/PABPN1 32 GO:0016125 sterol metabolic process 13/998 152/18722 0.0627123068110406 0.255049042042389 APP/LRP5/LIMA1/ABCA1/LPCAT3/CYB5R1/ACADVL/MBTPS1/DHCR24/NFE2L1/FDFT1/HDLBP/SQLE 13 GO:0021915 neural tube development 13/998 152/18722 0.0627123068110406 0.255049042042389 LRP2/SPINT1/BMP7/SPINT2/LMO4/DVL3/FOLR1/HECTD1/GLI3/COBL/SETD2/FZD6/ST14 13 GO:0043270 positive regulation of ion transport 21/998 275/18722 0.0627241850186606 0.255049042042389 TCAF1/ATP2B1/SLC6A4/AKAP9/ITGB1/DLG1/ANO6/ANK3/KCNN4/DMD/PRSS8/SLC9A1/HOMER1/PLA2R1/ACTN4/P2RX4/AHCYL1/PKP2/ABCB1/SNX4/GPD1L 21 GO:0019080 viral gene expression 9/998 94/18722 0.0629583339965769 0.255801915794652 FUT8/CANX/EIF3A/EIF2AK4/MOGS/DENR/MAN2A1/GSK3B/HEXIM1 9 GO:0006790 sulfur compound metabolic process 25/998 339/18722 0.0634432629105942 0.257571754009497 SLC26A2/ACSS1/ARL6IP5/CHPF/IDH1/MTR/TPST2/SLC19A3/B3GNT3/SMS/GLCE/CDO1/AHCYL1/ACSF2/B3GNT2/EXT2/ACSL3/GNS/FASN/FAR1/B4GAT1/TECR/NFE2L2/GLB1/HSPA9 25 GO:0045444 fat cell differentiation 18/998 229/18722 0.0646295220747402 0.262183943086417 BMP7/ADRB1/LRP5/YAP1/ADIRF/CDS1/CCND1/FERMT2/KLF5/PPARG/MAPK14/ARID5B/TCF7L2/GATA3/SDF4/ANKRD26/NIPBL/HNRNPU 18 GO:0032273 positive regulation of protein polymerization 12/998 138/18722 0.064973132894872 0.263373235127428 MET/CLIP1/AKAP9/DLG1/IQGAP2/SCIN/WASF2/HSP90AA1/MYO1C/NCKAP1/OCLN/HSPA1B 12 GO:0072665 protein localization to vacuole 7/998 67/18722 0.0652066716723962 0.263910102946961 RNF128/VPS13A/RTN4/NEDD4/GNPTAB/GCC2/ZFYVE16 7 GO:1903317 regulation of protein maturation 7/998 67/18722 0.0652066716723962 0.263910102946961 GLG1/MDM2/LPCAT3/CLN3/TMEM59/CAST/MMP14 7 GO:0042307 positive regulation of protein import into nucleus 5/998 41/18722 0.0653927290841354 0.264049063069042 CDH1/GLI3/TPR/MAPK14/UBR5 5 GO:0048286 lung alveolus development 5/998 41/18722 0.0653927290841354 0.264049063069042 MAN1A2/ERRFI1/FGFR2/MAN2A1/LTBP3 5 GO:2000008 regulation of protein localization to cell surface 5/998 41/18722 0.0653927290841354 0.264049063069042 LEPROT/TM9SF4/CTNNB1/GOPC/GPD1L 5 GO:0006821 chloride transport 10/998 109/18722 0.0654981688687775 0.264270432506868 SLC26A2/GABRE/CLDN4/FXYD3/ANO6/PCYOX1/SLC12A9/SLC1A3/GABRA4/ABCB1 10 GO:0010955 negative regulation of protein processing 4/998 29/18722 0.0661013316465283 0.264861897564485 GLG1/MDM2/TMEM59/CAST 4 GO:0015868 purine ribonucleotide transport 4/998 29/18722 0.0661013316465283 0.264861897564485 GJA1/CD47/SLC19A1/SLC29A1 4 GO:0031069 hair follicle morphogenesis 4/998 29/18722 0.0661013316465283 0.264861897564485 TP63/FGFR2/CTNNB1/BCL2 4 GO:0035066 positive regulation of histone acetylation 4/998 29/18722 0.0661013316465283 0.264861897564485 ISL1/RPS6KA5/BRD7/GATA3 4 GO:0040018 positive regulation of multicellular organism growth 4/998 29/18722 0.0661013316465283 0.264861897564485 EZR/BCL2/NIPBL/PPIB 4 GO:0071549 cellular response to dexamethasone stimulus 4/998 29/18722 0.0661013316465283 0.264861897564485 EGFR/SERPINF1/ERRFI1/ASS1 4 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/998 29/18722 0.0661013316465283 0.264861897564485 P4HB/PARP1/SFPQ/NFE2L2 4 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 4/998 29/18722 0.0661013316465283 0.264861897564485 SEMA6A/ATP2B4/PIK3CB/MYO1C 4 GO:1903318 negative regulation of protein maturation 4/998 29/18722 0.0661013316465283 0.264861897564485 GLG1/MDM2/TMEM59/CAST 4 GO:0031050 dsRNA processing 6/998 54/18722 0.0664977035434223 0.265634667329922 EGFR/LIN28B/PUM1/DICER1/AGO2/HNRNPA2B1 6 GO:0070839 metal ion export 6/998 54/18722 0.0664977035434223 0.265634667329922 ATP2B1/DLG1/SLC40A1/ANO6/ATP2B4/SLC9A1 6 GO:0070918 production of small RNA involved in gene silencing by RNA 6/998 54/18722 0.0664977035434223 0.265634667329922 EGFR/LIN28B/PUM1/DICER1/AGO2/HNRNPA2B1 6 GO:0072348 sulfur compound transport 6/998 54/18722 0.0664977035434223 0.265634667329922 SLC26A2/SLC13A4/GJA1/SLC13A3/SLC19A3/SLC5A6 6 GO:0031643 positive regulation of myelination 3/998 18/18722 0.0677850069287321 0.267519265805402 DAG1/DICER1/PARD3 3 GO:0036499 PERK-mediated unfolded protein response 3/998 18/18722 0.0677850069287321 0.267519265805402 HSPA5/PTPN1/NFE2L2 3 GO:0043217 myelin maintenance 3/998 18/18722 0.0677850069287321 0.267519265805402 DEGS1/EPB41L3/PLEC 3 GO:0048268 clathrin coat assembly 3/998 18/18722 0.0677850069287321 0.267519265805402 CLTC/CLINT1/NSG1 3 GO:0051895 negative regulation of focal adhesion assembly 3/998 18/18722 0.0677850069287321 0.267519265805402 LRP1/MMP14/PHLDB2 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/998 18/18722 0.0677850069287321 0.267519265805402 PARP1/TGFBR1/PPARG 3 GO:0061484 hematopoietic stem cell homeostasis 3/998 18/18722 0.0677850069287321 0.267519265805402 ADGRG1/FSTL1/OCIAD1 3 GO:0072079 nephron tubule formation 3/998 18/18722 0.0677850069287321 0.267519265805402 IRX2/CTNNB1/GATA3 3 GO:0097094 craniofacial suture morphogenesis 3/998 18/18722 0.0677850069287321 0.267519265805402 GLI3/MSX2/MMP14 3 GO:0098877 neurotransmitter receptor transport to plasma membrane 3/998 18/18722 0.0677850069287321 0.267519265805402 CLSTN1/VPS35/NSG1 3 GO:0150118 negative regulation of cell-substrate junction organization 3/998 18/18722 0.0677850069287321 0.267519265805402 LRP1/MMP14/PHLDB2 3 GO:1900006 positive regulation of dendrite development 3/998 18/18722 0.0677850069287321 0.267519265805402 BMP7/COBL/TMEM106B 3 GO:1901673 regulation of mitotic spindle assembly 3/998 18/18722 0.0677850069287321 0.267519265805402 TPR/HSPA1B/HNRNPU 3 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 3/998 18/18722 0.0677850069287321 0.267519265805402 SEMA6A/ATP2B4/PIK3CB 3 GO:1901987 regulation of cell cycle phase transition 28/998 390/18722 0.0677987602686664 0.267519265805402 EGFR/APP/DDB1/BRD4/PBX1/DLG1/ADAMTS1/FOXO4/PRKDC/CTDSPL/ATP2B4/MDM2/USP47/TPR/CCND1/EIF4G1/ANKRD17/WEE1/BRD7/RAD21/EIF2AK4/MAPK14/RDX/BCL2/ANAPC5/PLK2/XPC/PPP1R10 28 GO:0030216 keratinocyte differentiation 12/998 139/18722 0.0678405493059477 0.267519265805402 DSP/NCOA3/EXPH5/YAP1/OPN3/TP63/IRF6/ERRFI1/GRHL1/ST14/SGPP1/PLEC 12 GO:0045598 regulation of fat cell differentiation 12/998 139/18722 0.0678405493059477 0.267519265805402 BMP7/LRP5/YAP1/ADIRF/CDS1/FERMT2/KLF5/PPARG/MAPK14/GATA3/ANKRD26/HNRNPU 12 GO:0009636 response to toxic substance 20/998 262/18722 0.0682171593274877 0.268598634124294 CDH1/BMP7/SLC6A4/PON2/MGST3/MDM2/PPP1R9A/DNMT3A/KDM5B/PRDX4/GPX8/SLC22A5/ADH5/WAPL/BCL2/ABCB1/ASS1/SOD3/ALAD/NFE2L2 20 GO:0010466 negative regulation of peptidase activity 20/998 262/18722 0.0682171593274877 0.268598634124294 ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/IFI6/LRP1/SERPINH1/MDM2/USP47/SIAH2/DHCR24/BIRC6/CAST/GPC3/USP14/PEBP1/ANXA2 20 GO:0048259 regulation of receptor-mediated endocytosis 10/998 110/18722 0.0687841578268076 0.270219780296285 ITGAV/LRPAP1/AAK1/CD2AP/AHI1/FMR1/PIK3CB/ATXN2/OPHN1/ANXA2 10 GO:1904659 glucose transmembrane transport 10/998 110/18722 0.0687841578268076 0.270219780296285 SLC2A1/SLC5A3/OPN3/YES1/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 10 GO:1905954 positive regulation of lipid localization 10/998 110/18722 0.0687841578268076 0.270219780296285 LRP1/ABCA1/LPCAT3/PLA2R1/P2RX4/PPARG/TMEM30A/HILPDA/TMF1/ANXA2 10 GO:0034394 protein localization to cell surface 7/998 68/18722 0.0695138767868999 0.272676146284301 LEPROT/JAM3/TM9SF4/CTNNB1/GOPC/UNC50/GPD1L 7 GO:1901607 alpha-amino acid biosynthetic process 7/998 68/18722 0.0695138767868999 0.272676146284301 ATP2B4/MTR/CLN3/AASDHPPT/ALDH18A1/ASS1/SERINC3 7 GO:0042472 inner ear morphogenesis 9/998 96/18722 0.0700094349651 0.274413858823414 TFAP2A/ATP6V1B1/MYO7A/TRIOBP/FZD6/FGFR2/GATA3/ALDH1A3/MYO6 9 GO:0018210 peptidyl-threonine modification 11/998 125/18722 0.0701527378543371 0.274769275572014 APP/GALNT11/BMP7/PRKDC/EIF4G1/S1PR2/TGFBR1/PARD3/BCL2/GSK3B/CDC42BPB 11 GO:0006606 protein import into nucleus 13/998 155/18722 0.0708781829865897 0.2769203879036 CDH1/PTTG1IP/FERMT1/GLI3/TNPO1/TPR/MAPK14/RANBP17/IPO7/RANBP2/UBR5/PPP1R10/LMNA 13 GO:0007212 dopamine receptor signaling pathway 5/998 42/18722 0.0711262670328916 0.2769203879036 NCSTN/GSK3B/VPS35/NSG1/GNAS 5 GO:0014912 negative regulation of smooth muscle cell migration 5/998 42/18722 0.0711262670328916 0.2769203879036 SEMA6D/LRP1/GNA12/S1PR2/NFE2L2 5 GO:0043507 positive regulation of JUN kinase activity 5/998 42/18722 0.0711262670328916 0.2769203879036 DVL3/MAP3K4/PTPN1/FZD5/MAP3K13 5 GO:0045687 positive regulation of glial cell differentiation 5/998 42/18722 0.0711262670328916 0.2769203879036 SPINT1/DAG1/IL6ST/DICER1/HDAC2 5 GO:0060999 positive regulation of dendritic spine development 5/998 42/18722 0.0711262670328916 0.2769203879036 DLG5/PPP1R9A/CDKL5/FMR1/DHX36 5 GO:0072595 maintenance of protein localization in organelle 5/998 42/18722 0.0711262670328916 0.2769203879036 HSPA5/GJA1/SUN1/HNRNPU/KDELR1 5 GO:1904037 positive regulation of epithelial cell apoptotic process 5/998 42/18722 0.0711262670328916 0.2769203879036 ANO6/PRKCI/PLA2R1/PDCD4/TIA1 5 GO:0031113 regulation of microtubule polymerization 6/998 55/18722 0.0714415697320568 0.277940712049977 MET/CLIP1/AKAP9/CAMSAP2/OCLN/HSPA1B 6 GO:0071867 response to monoamine 10/998 111/18722 0.0721729805567379 0.280368401403816 APP/TGM2/ATP2B4/SLC9A1/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 10 GO:0071869 response to catecholamine 10/998 111/18722 0.0721729805567379 0.280368401403816 APP/TGM2/ATP2B4/SLC9A1/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 10 GO:0007596 blood coagulation 17/998 217/18722 0.0727043006563532 0.280991726431906 F5/FBLN1/LMAN1/ANO6/GNA12/IL6ST/VAV3/HPS5/CD59/PIK3CB/FZD6/MAPK14/ANXA5/AK3/NFE2L2/ANXA2/GNAS 17 GO:0003299 muscle hypertrophy in response to stress 4/998 30/18722 0.0731945504591827 0.280991726431906 ATP2B4/ERRFI1/ATP2A2/LMNA 4 GO:0006884 cell volume homeostasis 4/998 30/18722 0.0731945504591827 0.280991726431906 ANO6/KCNN4/SLC12A9/CLN3 4 GO:0014887 cardiac muscle adaptation 4/998 30/18722 0.0731945504591827 0.280991726431906 ATP2B4/ERRFI1/ATP2A2/LMNA 4 GO:0014898 cardiac muscle hypertrophy in response to stress 4/998 30/18722 0.0731945504591827 0.280991726431906 ATP2B4/ERRFI1/ATP2A2/LMNA 4 GO:0015865 purine nucleotide transport 4/998 30/18722 0.0731945504591827 0.280991726431906 GJA1/CD47/SLC19A1/SLC29A1 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/998 30/18722 0.0731945504591827 0.280991726431906 PRKDC/MDM2/CCND1/PLK2 4 GO:0044788 modulation by host of viral process 4/998 30/18722 0.0731945504591827 0.280991726431906 FMR1/EIF2AK4/STOM/PPIB 4 GO:0045070 positive regulation of viral genome replication 4/998 30/18722 0.0731945504591827 0.280991726431906 DDB1/HACD3/TOP2B/PKN2 4 GO:0051491 positive regulation of filopodium assembly 4/998 30/18722 0.0731945504591827 0.280991726431906 NRP1/FNBP1L/FMR1/TGFBR1 4 GO:0060292 long-term synaptic depression 4/998 30/18722 0.0731945504591827 0.280991726431906 PPP1R9A/FMR1/PLK2/SHANK2 4 GO:0060603 mammary gland duct morphogenesis 4/998 30/18722 0.0731945504591827 0.280991726431906 LRP5/KDM5B/FGFR2/DDR1 4 GO:0060674 placenta blood vessel development 4/998 30/18722 0.0731945504591827 0.280991726431906 SPINT1/ITGB8/NR2F2/FZD5 4 GO:0090314 positive regulation of protein targeting to membrane 4/998 30/18722 0.0731945504591827 0.280991726431906 TCAF1/ANK3/MYO1C/STOM 4 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 4/998 30/18722 0.0731945504591827 0.280991726431906 HSPA5/UFL1/PTPN1/ATF6 4 GO:1902751 positive regulation of cell cycle G2/M phase transition 4/998 30/18722 0.0731945504591827 0.280991726431906 APP/BRD4/PBX1/CCND1 4 GO:2001235 positive regulation of apoptotic signaling pathway 11/998 126/18722 0.0733562701311705 0.281405647578869 MAGED1/PDIA3/SIAH1/TP63/SFPQ/BCLAF1/TGFBR1/BCAP31/SERINC3/PMAIP1/CTNNA1 11 GO:0032355 response to estradiol 12/998 141/18722 0.0738194149481467 0.282974423967896 EGFR/BMP7/SLC6A4/NCOA3/GJA1/NR2F2/CALR/DNMT3A/CCND1/MMP15/CTNNB1/ASS1 12 GO:0050805 negative regulation of synaptic transmission 7/998 69/18722 0.0739869424510561 0.283408530107824 SLC6A4/PPP1R9A/S1PR2/FMR1/GNAI1/PLK2/SHANK2 7 GO:0045926 negative regulation of growth 19/998 249/18722 0.0742410427813843 0.284173375631677 SEMA6A/SEMA6D/NRP1/SLC6A4/ADRB1/SMARCA2/GJA1/RBBP7/SPAG9/RTN4/SEMA3F/DCBLD2/RYK/VGLL4/SEMA4B/BCL2/HSPA1B/GPC3/YY1 19 GO:0050886 endocrine process 8/998 83/18722 0.0744753943262938 0.284861563207018 MME/ENPEP/GJA1/TRPV6/KRAS/RAB11FIP1/GATA3/TMF1 8 GO:0006470 protein dephosphorylation 21/998 281/18722 0.0748795952136685 0.286197925776401 HSP90B1/DLG1/SLC39A10/PTPN14/CTDSPL/CAMK2G/PTP4A1/SWAP70/PTPN1/PTPRM/PPP4R1/BOD1L1/BCL2/DUSP14/PTPRA/SPPL3/GSK3B/PPP2R2B/PDP2/DUSP5/PPP6R2 21 GO:0043406 positive regulation of MAP kinase activity 10/998 112/18722 0.0756650413080862 0.288988427702647 EGFR/MAGED1/CD24/DVL3/MAP3K4/ERP29/PTPN1/KRAS/FZD5/MAP3K13 10 GO:0006687 glycosphingolipid metabolic process 6/998 56/18722 0.076590823408198 0.290609956931922 ITGB8/HEXB/HEXA/GM2A/SUMF1/GLB1 6 GO:0022029 telencephalon cell migration 6/998 56/18722 0.076590823408198 0.290609956931922 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:0051058 negative regulation of small GTPase mediated signal transduction 6/998 56/18722 0.076590823408198 0.290609956931922 MET/KANK1/RASA1/ITGB1/CCDC125/CD2AP 6 GO:0090175 regulation of establishment of planar polarity 6/998 56/18722 0.076590823408198 0.290609956931922 ZNRF3/DVL3/RYK/FZD6/DAAM1/GPC3 6 GO:1904645 response to amyloid-beta 6/998 56/18722 0.076590823408198 0.290609956931922 APP/GJA1/IGF1R/LRP1/PARP1/GSK3B 6 GO:0002262 myeloid cell homeostasis 13/998 157/18722 0.0766904921833781 0.290609956931922 CDK6/TGFBR3/PRKDC/RCOR1/UFL1/NCSTN/PIK3CB/JAM3/MAPK14/GATA3/RBFOX2/HSPA1B/HSPA9 13 GO:0070646 protein modification by small protein removal 13/998 157/18722 0.0766904921833781 0.290609956931922 USP53/USP25/USP27X/USP47/USP9X/USP10/USP48/VCP/USP34/USP22/OTUD4/OTUD7B/USP14 13 GO:0060249 anatomical structure homeostasis 23/998 314/18722 0.0769133649007755 0.290609956931922 EGFR/SLC2A1/ATP2B1/LAMC1/TFRC/ITGB1/GJA1/NF1/GCNT2/YAP1/DMD/HOMER1/TJP1/LSR/P2RX4/KRAS/JAM3/SLC22A5/CTNNB1/GAA/BCL2/OCLN/LTBP3 23 GO:0001504 neurotransmitter uptake 5/998 43/18722 0.0771264665135988 0.290609956931922 SLC6A4/ITGB1/SLC38A1/SLC1A3/SLC29A1 5 GO:0033173 calcineurin-NFAT signaling cascade 5/998 43/18722 0.0771264665135988 0.290609956931922 NFAT5/ATP2B4/SLC9A1/SPPL3/GSK3B 5 GO:0060443 mammary gland morphogenesis 5/998 43/18722 0.0771264665135988 0.290609956931922 LRP5/GLI3/KDM5B/FGFR2/DDR1 5 GO:0098927 vesicle-mediated transport between endosomal compartments 5/998 43/18722 0.0771264665135988 0.290609956931922 EEA1/HOOK2/EZR/RDX/AKTIP 5 GO:1903793 positive regulation of anion transport 5/998 43/18722 0.0771264665135988 0.290609956931922 TCAF1/ITGB1/PLA2R1/P2RX4/ABCB1 5 GO:1904591 positive regulation of protein import 5/998 43/18722 0.0771264665135988 0.290609956931922 CDH1/GLI3/TPR/MAPK14/UBR5 5 GO:0006670 sphingosine metabolic process 3/998 19/18722 0.0774254836415061 0.290609956931922 PLPP3/SPTLC3/SGPP1 3 GO:0009301 snRNA transcription 3/998 19/18722 0.0774254836415061 0.290609956931922 ICE1/CDK7/ELL 3 GO:0031290 retinal ganglion cell axon guidance 3/998 19/18722 0.0774254836415061 0.290609956931922 NRP1/ISL1/PTPRM 3 GO:0032011 ARF protein signal transduction 3/998 19/18722 0.0774254836415061 0.290609956931922 CYTH3/ARFGEF3/ARFGEF1 3 GO:0032012 regulation of ARF protein signal transduction 3/998 19/18722 0.0774254836415061 0.290609956931922 CYTH3/ARFGEF3/ARFGEF1 3 GO:0032026 response to magnesium ion 3/998 19/18722 0.0774254836415061 0.290609956931922 ANK3/MDM2/CCND1 3 GO:0035313 wound healing, spreading of epidermal cells 3/998 19/18722 0.0774254836415061 0.290609956931922 FERMT1/FERMT2/PHLDB2 3 GO:0036498 IRE1-mediated unfolded protein response 3/998 19/18722 0.0774254836415061 0.290609956931922 HSPA5/UFL1/PTPN1 3 GO:0045780 positive regulation of bone resorption 3/998 19/18722 0.0774254836415061 0.290609956931922 EGFR/TFRC/LTBP3 3 GO:2000738 positive regulation of stem cell differentiation 3/998 19/18722 0.0774254836415061 0.290609956931922 TACSTD2/DHX36/LTBP3 3 GO:2001020 regulation of response to DNA damage stimulus 17/998 219/18722 0.0776324670183953 0.291177521769427 EGFR/PARP1/FUS/PRKDC/PTTG1IP/MDM2/USP47/SMYD2/BCLAF1/FMR1/PLA2R1/SETD2/RIF1/BCL2/UBR5/PMAIP1/PPP1R10 17 GO:0048839 inner ear development 15/998 188/18722 0.0778455597772574 0.291767169847136 LGR5/TRIP11/TFAP2A/MCOLN3/GLI3/ATP6V1B1/MYO7A/AHI1/ESRP1/TRIOBP/FZD6/FGFR2/GATA3/ALDH1A3/MYO6 15 GO:0060415 muscle tissue morphogenesis 7/998 70/18722 0.0786257355789012 0.294243161724073 LRP2/DSP/TGFBR3/ISL1/TGFBR1/FGFR2/PKP2 7 GO:0009410 response to xenobiotic stimulus 32/998 462/18722 0.0786448994332279 0.294243161724073 EGFR/CDH1/SLC6A4/TFRC/HSPA5/RPN2/CALR/GNA12/HADHA/VAV3/DVL3/HSPD1/GGH/MDM2/ABCA1/ADIRF/DNMT3A/USP47/TLR3/SLC1A3/PTPRM/CYP2J2/GATA3/BCL2/ABCB1/ASS1/MYO6/ALAD/XPC/HDAC2/NFE2L2/PNP 32 GO:0098586 cellular response to virus 8/998 84/18722 0.0786752449275629 0.294243161724073 IFI6/TLR3/PUM1/FMR1/ANKRD17/HSP90AA1/MAPK14/LGALS8 8 GO:0000910 cytokinesis 14/998 173/18722 0.0789158368790537 0.294931699603106 MYH10/RASA1/ANK3/SON/BIRC6/SETD2/UVRAG/PKN2/RAB11FIP4/PLK2/SPTBN1/PLEC/TTC19/PRPF40A 14 GO:0032412 regulation of ion transmembrane transporter activity 20/998 267/18722 0.0791677773974016 0.29566163504423 APP/TCAF1/AHNAK/UTRN/AKAP9/ITGB1/DLG1/FXYD3/ANK3/DMD/SLC9A1/HOMER1/FMR1/NEDD4/ACTN4/AHCYL1/GOPC/ABCB1/STOM/GPD1L 20 GO:0035115 embryonic forelimb morphogenesis 4/998 31/18722 0.080656791379027 0.299508611514865 TFAP2A/TP63/CTNNB1/NIPBL 4 GO:0035510 DNA dealkylation 4/998 31/18722 0.080656791379027 0.299508611514865 TET2/USP9X/GATA3/OTUD4 4 GO:0036474 cell death in response to hydrogen peroxide 4/998 31/18722 0.080656791379027 0.299508611514865 MET/STK26/PAWR/NFE2L2 4 GO:0036475 neuron death in response to oxidative stress 4/998 31/18722 0.080656791379027 0.299508611514865 ARL6IP5/PARP1/CTNNB1/OXR1 4 GO:0044819 mitotic G1/S transition checkpoint signaling 4/998 31/18722 0.080656791379027 0.299508611514865 PRKDC/MDM2/CCND1/PLK2 4 GO:0048384 retinoic acid receptor signaling pathway 4/998 31/18722 0.080656791379027 0.299508611514865 CALR/ESRRG/ACTN4/PPARG 4 GO:0060045 positive regulation of cardiac muscle cell proliferation 4/998 31/18722 0.080656791379027 0.299508611514865 TGFBR3/YAP1/MAPK14/FGFR2 4 GO:0090183 regulation of kidney development 4/998 31/18722 0.080656791379027 0.299508611514865 MAGED1/LGR4/TACSTD2/GATA3 4 GO:0060291 long-term synaptic potentiation 9/998 99/18722 0.0814732349906114 0.302175471984215 APP/MME/PPP1R9A/NCSTN/EIF2AK4/PLK2/GSK3B/SHANK2/NSG1 9 GO:0050708 regulation of protein secretion 20/998 268/18722 0.0814907229560955 0.302175471984215 EGFR/MYH10/WLS/DPP4/GJA1/LRP5/LRP1/EXPH5/FRMD4A/KCNN4/ISL1/SYT7/EXOC1/SLC16A1/CD2AP/ERP29/EZR/TCF7L2/RAB11FIP1/P3H1 20 GO:0002011 morphogenesis of an epithelial sheet 6/998 57/18722 0.0819444210476501 0.302997041281715 DAG1/BMP7/FERMT1/FERMT2/DDR1/PHLDB2 6 GO:0016447 somatic recombination of immunoglobulin gene segments 6/998 57/18722 0.0819444210476501 0.302997041281715 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0060042 retina morphogenesis in camera-type eye 6/998 57/18722 0.0819444210476501 0.302997041281715 LRP5/TFAP2A/OBSL1/AHI1/PTPRM/MAN2A1 6 GO:0061005 cell differentiation involved in kidney development 6/998 57/18722 0.0819444210476501 0.302997041281715 LGR4/CD24/YAP1/GLI3/CTNNB1/GATA3 6 GO:0051170 import into nucleus 13/998 159/18722 0.0828007352182347 0.305946665657752 CDH1/PTTG1IP/FERMT1/GLI3/TNPO1/TPR/MAPK14/RANBP17/IPO7/RANBP2/UBR5/PPP1R10/LMNA 13 GO:0008645 hexose transmembrane transport 10/998 114/18722 0.0829599797978537 0.306318284670859 SLC2A1/SLC5A3/OPN3/YES1/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 10 GO:0007528 neuromuscular junction development 5/998 44/18722 0.0833903769034085 0.30653569631164 APP/ANK3/PPFIBP1/AFG3L2/NEDD4 5 GO:0008542 visual learning 5/998 44/18722 0.0833903769034085 0.30653569631164 APP/ITGB1/NF1/KRAS/MEIS2 5 GO:0051150 regulation of smooth muscle cell differentiation 5/998 44/18722 0.0833903769034085 0.30653569631164 DNMT1/FOXO4/ANKRD17/FGFR2/PDCD4 5 GO:0060324 face development 5/998 44/18722 0.0833903769034085 0.30653569631164 ANKRD11/ARID5B/PLEKHA1/ALDH1A3/NIPBL 5 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 5/998 44/18722 0.0833903769034085 0.30653569631164 TLR3/PUM1/RTN4/ANKRD17/HSPA1B 5 GO:1903214 regulation of protein targeting to mitochondrion 5/998 44/18722 0.0833903769034085 0.30653569631164 LMAN1/HUWE1/LEPROT/NPEPPS/FZD5 5 GO:0033555 multicellular organismal response to stress 7/998 71/18722 0.0834298457113273 0.30653569631164 ADRB1/DPP4/GJA1/VWA1/EIF4G1/P2RX4/BCL2 7 GO:0007498 mesoderm development 11/998 129/18722 0.0835168691833189 0.306639644167446 ITGB4/WLS/BMP7/ITGB1/GJA1/MEST/YAP1/TP63/SETD2/FGFR2/EXT2 11 GO:0052548 regulation of endopeptidase activity 30/998 432/18722 0.0841832184922316 0.308868997714646 ITIH5/APP/SPINT1/APLP2/CRIM1/ASPH/SERPINF1/PERP/SPINT2/IFI6/ARL6IP5/SERPINH1/HSPD1/MDM2/USP47/EFNA1/TP63/SIAH2/DHCR24/BIRC6/NCSTN/PPARG/BCAP31/VCP/CAST/NRDC/PMAIP1/USP14/PEBP1/ANXA2 30 GO:0017038 protein import 16/998 206/18722 0.0846150865645133 0.31023551050093 CDH1/PTTG1IP/HSPD1/FERMT1/GLI3/TNPO1/TPR/HSP90AA1/MAPK14/RANBP17/IPO7/RANBP2/UBR5/PPP1R10/LMNA/TOMM20 16 GO:0007599 hemostasis 17/998 222/18722 0.0854291228446617 0.312499643814859 F5/FBLN1/LMAN1/ANO6/GNA12/IL6ST/VAV3/HPS5/CD59/PIK3CB/FZD6/MAPK14/ANXA5/AK3/NFE2L2/ANXA2/GNAS 17 GO:0050817 coagulation 17/998 222/18722 0.0854291228446617 0.312499643814859 F5/FBLN1/LMAN1/ANO6/GNA12/IL6ST/VAV3/HPS5/CD59/PIK3CB/FZD6/MAPK14/ANXA5/AK3/NFE2L2/ANXA2/GNAS 17 GO:0006626 protein targeting to mitochondrion 9/998 100/18722 0.0855318887208261 0.312499643814859 LMAN1/HSPD1/HUWE1/LEPROT/NPEPPS/HSP90AA1/BCAP31/FZD5/TOMM20 9 GO:0009062 fatty acid catabolic process 9/998 100/18722 0.0855318887208261 0.312499643814859 SLC27A2/HADHA/CROT/ECHDC2/ACADVL/ECI2/CPT2/ECHDC1/ETFA 9 GO:0044728 DNA methylation or demethylation 9/998 100/18722 0.0855318887208261 0.312499643814859 DNMT1/PARP1/DNMT3A/ATRX/TET2/USP9X/MPHOSPH8/GATA3/OTUD4 9 GO:0042471 ear morphogenesis 10/998 115/18722 0.0867631502540209 0.316620877502429 TFAP2A/ATP6V1B1/MYO7A/TRIOBP/FZD6/FGFR2/GATA3/ALDH1A3/NIPBL/MYO6 10 GO:0050679 positive regulation of epithelial cell proliferation 16/998 207/18722 0.0874136544561595 0.316620877502429 EGFR/NRP2/LAMB1/LAMC1/NRP1/YAP1/B4GALT1/KDM5B/CCND1/TP63/RTN4/TGFBR1/FGFR2/CTNNB1/TCF7L2/EMC10 16 GO:0015908 fatty acid transport 8/998 86/18722 0.0874900268394249 0.316620877502429 SLC2A1/SLC27A2/CROT/PLA2R1/P2RX4/PPARG/CPT2/ACSL3 8 GO:0043506 regulation of JUN kinase activity 6/998 58/18722 0.0875008980734246 0.316620877502429 DVL3/MAP3K4/PTPN1/FZD5/PDCD4/MAP3K13 6 GO:0045604 regulation of epidermal cell differentiation 6/998 58/18722 0.0875008980734246 0.316620877502429 NCOA3/TP63/ESRP1/ERRFI1/GRHL1/SGPP1 6 GO:0086065 cell communication involved in cardiac conduction 6/998 58/18722 0.0875008980734246 0.316620877502429 DSP/DSC2/GJA1/GJA5/DSG2/PKP2 6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/998 58/18722 0.0875008980734246 0.316620877502429 SIAH1/SFPQ/BCLAF1/BCAP31/SERINC3/PMAIP1 6 GO:0003215 cardiac right ventricle morphogenesis 3/998 20/18722 0.0876269224511534 0.316620877502429 ISL1/PPP1R13L/GATA3 3 GO:0006346 DNA methylation-dependent heterochromatin assembly 3/998 20/18722 0.0876269224511534 0.316620877502429 DNMT1/DNMT3A/MPHOSPH8 3 GO:0006525 arginine metabolic process 3/998 20/18722 0.0876269224511534 0.316620877502429 ATP2B4/CLN3/ASS1 3 GO:0043555 regulation of translation in response to stress 3/998 20/18722 0.0876269224511534 0.316620877502429 EIF2AK1/EIF4G1/EIF2AK4 3 GO:0051900 regulation of mitochondrial depolarization 3/998 20/18722 0.0876269224511534 0.316620877502429 IFI6/PARP1/BCL2 3 GO:0060252 positive regulation of glial cell proliferation 3/998 20/18722 0.0876269224511534 0.316620877502429 EGFR/UFL1/PRKCI 3 GO:0071243 cellular response to arsenic-containing substance 3/998 20/18722 0.0876269224511534 0.316620877502429 VCP/DHX36/SLC38A2 3 GO:0008202 steroid metabolic process 23/998 319/18722 0.0877321420693721 0.316620877502429 LRP2/APP/STS/SLC27A2/PBX1/LRP5/PRLR/LIMA1/ABCA1/LPCAT3/CYB5R1/SF1/HSD17B1/ACADVL/MBTPS1/DHCR24/OSBPL9/NFE2L1/PLEKHA1/FDFT1/HDLBP/ACBD3/SQLE 23 GO:0010634 positive regulation of epithelial cell migration 14/998 176/18722 0.087890835428936 0.316620877502429 MET/NRP2/NRP1/CALR/PLPP3/RTN4/P2RX4/PIK3CB/DOCK1/GATA3/PLK2/EMC10/ANXA3/NFE2L2 14 GO:0050920 regulation of chemotaxis 17/998 223/18722 0.0881366737798018 0.316620877502429 MET/SEMA6A/SEMA6D/NRP1/DPP4/ANO6/CALR/MYCBP2/SEMA3F/TPBG/P2RX4/SWAP70/JAM3/RYK/SEMA4B/PTK2/USP14 17 GO:0001707 mesoderm formation 7/998 72/18722 0.0883985885963397 0.316620877502429 ITGB4/WLS/BMP7/ITGB1/GJA1/FGFR2/EXT2 7 GO:0001736 establishment of planar polarity 7/998 72/18722 0.0883985885963397 0.316620877502429 ZNRF3/DVL3/TP63/RYK/FZD6/DAAM1/GPC3 7 GO:0007164 establishment of tissue polarity 7/998 72/18722 0.0883985885963397 0.316620877502429 ZNRF3/DVL3/TP63/RYK/FZD6/DAAM1/GPC3 7 GO:0035567 non-canonical Wnt signaling pathway 7/998 72/18722 0.0883985885963397 0.316620877502429 ZNRF3/DVL3/RYK/FZD6/FZD5/DAAM1/GPC3 7 GO:0071479 cellular response to ionizing radiation 7/998 72/18722 0.0883985885963397 0.316620877502429 HSPA5/YAP1/NET1/MDM2/MAPK14/GATA3/NIPBL 7 GO:0006026 aminoglycan catabolic process 4/998 32/18722 0.088479191778595 0.316620877502429 FUCA1/GUSB/GNS/GLB1 4 GO:0010644 cell communication by electrical coupling 4/998 32/18722 0.088479191778595 0.316620877502429 GJA1/GJA5/ANK3/PKP2 4 GO:0045879 negative regulation of smoothened signaling pathway 4/998 32/18722 0.088479191778595 0.316620877502429 GLI3/VCP/HERC4/GPC3 4 GO:0060323 head morphogenesis 4/998 32/18722 0.088479191778595 0.316620877502429 ANKRD11/ARID5B/PLEKHA1/NIPBL 4 GO:0060914 heart formation 4/998 32/18722 0.088479191778595 0.316620877502429 LRP2/FOLR1/ISL1/CTNNB1 4 GO:0061037 negative regulation of cartilage development 4/998 32/18722 0.088479191778595 0.316620877502429 EFEMP1/TGFBR1/CTNNB1/LTBP3 4 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/998 32/18722 0.088479191778595 0.316620877502429 ERP29/PTPN1/SERINC3/PMAIP1 4 GO:1903955 positive regulation of protein targeting to mitochondrion 4/998 32/18722 0.088479191778595 0.316620877502429 HUWE1/LEPROT/NPEPPS/FZD5 4 GO:0051650 establishment of vesicle localization 13/998 161/18722 0.0892107558622276 0.319020107093624 TRIP11/CCDC186/DYNC1H1/FNBP1L/LIMK2/MYO7A/CLN3/TMED9/ACTN4/CTNNB1/MYO1C/MYO6/TFG 13 GO:0015749 monosaccharide transmembrane transport 10/998 116/18722 0.0906701435293907 0.323795362084096 SLC2A1/SLC5A3/OPN3/YES1/PRKCI/SORBS1/MAPK14/OCLN/GPC3/NFE2L2 10 GO:0018107 peptidyl-threonine phosphorylation 10/998 116/18722 0.0906701435293907 0.323795362084096 APP/BMP7/PRKDC/EIF4G1/S1PR2/TGFBR1/PARD3/BCL2/GSK3B/CDC42BPB 10 GO:0046683 response to organophosphorus 11/998 131/18722 0.0907509655597753 0.323862468344215 APP/HSP90B1/SLC6A4/AKAP9/HSPA5/HSPD1/BSG/EZR/P2RX4/CDO1/ASS1 11 GO:0051648 vesicle localization 14/998 177/18722 0.0910198042071463 0.32459999847371 TRIP11/CCDC186/DYNC1H1/FNBP1L/LIMK2/MYO7A/CLN3/TMED9/ACTN4/CTNNB1/USO1/MYO1C/MYO6/TFG 14 GO:0007389 pattern specification process 30/998 436/18722 0.0919075512305243 0.327338702646591 LRP2/GALNT11/NRP2/ADGRG1/WLS/NRP1/BMP7/PBX1/NR2F2/LRP5/PGAP1/PRKDC/FOLR1/ISL1/GLI3/COBL/BPTF/IRX2/TP63/AHI1/SEMA3F/TGFBR1/FGFR2/TRA2B/CTNNB1/FZD5/BHLHE41/MEIS2/GPC3/YY1 30 GO:0072503 cellular divalent inorganic cation homeostasis 33/998 486/18722 0.0919131465389586 0.327338702646591 APP/ATP2B1/HSP90B1/ITGAV/GJA1/SLC39A10/CD55/TGM2/CCDC47/LRP1/CD24/CALR/ATP13A3/GTF2I/ATP2B4/HEXB/MCOLN3/DMD/SLC39A7/CLN3/TRPV6/AFG3L2/P2RX4/SWAP70/BCAP31/TRPM7/TMEM165/GPR157/BCL2/ATP2A2/STC2/SPPL3/SLC30A7 33 GO:0021885 forebrain cell migration 6/998 59/18722 0.0932583805398922 0.33082572700707 LAMB1/ADGRG1/GLI3/RTN4/CTNNB1/SUN1 6 GO:0043407 negative regulation of MAP kinase activity 6/998 59/18722 0.0932583805398922 0.33082572700707 BMP7/NF1/PTPN1/PPARG/PIK3CB/PDCD4 6 GO:0048010 vascular endothelial growth factor receptor signaling pathway 6/998 59/18722 0.0932583805398922 0.33082572700707 NRP1/EPN2/NEDD4/PTPN1/MAPK14/PTK2 6 GO:0051568 histone H3-K4 methylation 6/998 59/18722 0.0932583805398922 0.33082572700707 DNMT1/ASH1L/TET2/CTNNB1/KMT2C/GATA3 6 GO:0071806 protein transmembrane transport 6/998 59/18722 0.0932583805398922 0.33082572700707 HSPA5/HSPD1/ABCA1/TRAM2/SEC63/TOMM20 6 GO:0061035 regulation of cartilage development 7/998 73/18722 0.0935310105669818 0.33082572700707 EFEMP1/GLG1/SCIN/GLI3/TGFBR1/CTNNB1/LTBP3 7 GO:0005996 monosaccharide metabolic process 19/998 257/18722 0.0939684373626277 0.33082572700707 SLC2A1/DDB1/LRP5/SLC35B4/FUT8/FUCA1/B4GALT1/UXS1/RPIA/SORBS1/MAPK14/FAM3C/GAA/RANBP2/MAN2A1/GSK3B/PMAIP1/PHLDA2/GLB1 19 GO:0035725 sodium ion transmembrane transport 14/998 178/18722 0.0942176171297028 0.33082572700707 SLC6A4/UTRN/DLG1/FXYD3/ANO6/ANK3/ATP2B4/DMD/SLC9A1/NEDD4/ACTN4/SLC20A2/STOM/GPD1L 14 GO:0061025 membrane fusion 13/998 163/18722 0.0959215650024652 0.33082572700707 CTSL/SPESP1/MYOF/EEA1/VAV3/FOLR1/SYT7/HUWE1/CLN3/UVRAG/USO1/RABEP1/ANXA2 13 GO:0002002 regulation of angiotensin levels in blood 2/998 10/18722 0.0961498819472542 0.33082572700707 MME/ENPEP 2 GO:0002003 angiotensin maturation 2/998 10/18722 0.0961498819472542 0.33082572700707 MME/ENPEP 2 GO:0005984 disaccharide metabolic process 2/998 10/18722 0.0961498819472542 0.33082572700707 B4GALT1/GAA 2 GO:0006012 galactose metabolic process 2/998 10/18722 0.0961498819472542 0.33082572700707 B4GALT1/GLB1 2 GO:0010172 embryonic body morphogenesis 2/998 10/18722 0.0961498819472542 0.33082572700707 DAG1/PHLDB2 2 GO:0010944 negative regulation of transcription by competitive promoter binding 2/998 10/18722 0.0961498819472542 0.33082572700707 TFAP2A/BHLHE41 2 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 2/998 10/18722 0.0961498819472542 0.33082572700707 EIF2AK1/EIF2AK4 2 GO:0014041 regulation of neuron maturation 2/998 10/18722 0.0961498819472542 0.33082572700707 BCL2/MAP3K13 2 GO:0016139 glycoside catabolic process 2/998 10/18722 0.0961498819472542 0.33082572700707 FUCA1/GUSB 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/998 10/18722 0.0961498819472542 0.33082572700707 P4HB/PRDX4 2 GO:0021562 vestibulocochlear nerve development 2/998 10/18722 0.0961498819472542 0.33082572700707 NRP2/NRP1 2 GO:0032025 response to cobalt ion 2/998 10/18722 0.0961498819472542 0.33082572700707 SERPINF1/ALAD 2 GO:0033572 transferrin transport 2/998 10/18722 0.0961498819472542 0.33082572700707 TFRC/CLTC 2 GO:0034085 establishment of sister chromatid cohesion 2/998 10/18722 0.0961498819472542 0.33082572700707 WAPL/NIPBL 2 GO:0044848 biological phase 2/998 10/18722 0.0961498819472542 0.33082572700707 FERMT1/CTNNB1 2 GO:0048194 Golgi vesicle budding 2/998 10/18722 0.0961498819472542 0.33082572700707 TMED9/PRKCI 2 GO:0060272 embryonic skeletal joint morphogenesis 2/998 10/18722 0.0961498819472542 0.33082572700707 BMP7/CTNNB1 2 GO:0060513 prostatic bud formation 2/998 10/18722 0.0961498819472542 0.33082572700707 BMP7/TP63 2 GO:0060525 prostate glandular acinus development 2/998 10/18722 0.0961498819472542 0.33082572700707 TP63/FGFR2 2 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 2/998 10/18722 0.0961498819472542 0.33082572700707 SERPINF1/CTNNB1 2 GO:0061299 retina vasculature morphogenesis in camera-type eye 2/998 10/18722 0.0961498819472542 0.33082572700707 NRP1/LRP5 2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 2/998 10/18722 0.0961498819472542 0.33082572700707 ERLEC1/UBE2G2 2 GO:0072203 cell proliferation involved in metanephros development 2/998 10/18722 0.0961498819472542 0.33082572700707 BMP7/GPC3 2 GO:0097278 complement-dependent cytotoxicity 2/998 10/18722 0.0961498819472542 0.33082572700707 CD55/CD59 2 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 2/998 10/18722 0.0961498819472542 0.33082572700707 VPS35/NSG1 2 GO:0140059 dendrite arborization 2/998 10/18722 0.0961498819472542 0.33082572700707 NRP1/TPBG 2 GO:1900246 positive regulation of RIG-I signaling pathway 2/998 10/18722 0.0961498819472542 0.33082572700707 PUM1/ANKRD17 2 GO:1901203 positive regulation of extracellular matrix assembly 2/998 10/18722 0.0961498819472542 0.33082572700707 DAG1/PHLDB2 2 GO:1902023 L-arginine transport 2/998 10/18722 0.0961498819472542 0.33082572700707 SLC38A9/SLC7A2 2 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/998 10/18722 0.0961498819472542 0.33082572700707 SERINC3/PMAIP1 2 GO:1902855 regulation of non-motile cilium assembly 2/998 10/18722 0.0961498819472542 0.33082572700707 ATMIN/MAP4 2 GO:1903826 arginine transmembrane transport 2/998 10/18722 0.0961498819472542 0.33082572700707 SLC38A9/SLC7A2 2 GO:2000121 regulation of removal of superoxide radicals 2/998 10/18722 0.0961498819472542 0.33082572700707 BMP7/NFE2L2 2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 2/998 10/18722 0.0961498819472542 0.33082572700707 WASF2/NCKAP1 2 GO:2000674 regulation of type B pancreatic cell apoptotic process 2/998 10/18722 0.0961498819472542 0.33082572700707 CAST/TCF7L2 2 GO:2001225 regulation of chloride transport 2/998 10/18722 0.0961498819472542 0.33082572700707 GABRE/ABCB1 2 GO:0002431 Fc receptor mediated stimulatory signaling pathway 4/998 33/18722 0.0966517463791818 0.33082572700707 CD47/VAV3/YES1/PTK2 4 GO:0003382 epithelial cell morphogenesis 4/998 33/18722 0.0966517463791818 0.33082572700707 MET/SPINT2/FAT1/ST14 4 GO:0006891 intra-Golgi vesicle-mediated transport 4/998 33/18722 0.0966517463791818 0.33082572700707 CUX1/RAB6A/COPB1/COPB2 4 GO:0010984 regulation of lipoprotein particle clearance 4/998 33/18722 0.0966517463791818 0.33082572700707 LRPAP1/CNPY2/MYLIP/ANXA2 4 GO:0036336 dendritic cell migration 4/998 33/18722 0.0966517463791818 0.33082572700707 ANO6/CALR/DOCK8/EPS8 4 GO:0042558 pteridine-containing compound metabolic process 4/998 33/18722 0.0966517463791818 0.33082572700707 SLC19A1/MTR/GGH/FOLR1 4 GO:0048333 mesodermal cell differentiation 4/998 33/18722 0.0966517463791818 0.33082572700707 ITGB4/ITGB1/GJA1/FGFR2 4 GO:0048730 epidermis morphogenesis 4/998 33/18722 0.0966517463791818 0.33082572700707 TP63/FGFR2/CTNNB1/BCL2 4 GO:0071295 cellular response to vitamin 4/998 33/18722 0.0966517463791818 0.33082572700707 ATP2B1/MDM2/FOLR1/TRIM24 4 GO:0071353 cellular response to interleukin-4 4/998 33/18722 0.0966517463791818 0.33082572700707 HSPA5/GATA3/FASN/ALAD 4 GO:1901099 negative regulation of signal transduction in absence of ligand 4/998 33/18722 0.0966517463791818 0.33082572700707 IFI6/BCL2/HSPA1B/CTNNA1 4 GO:1902692 regulation of neuroblast proliferation 4/998 33/18722 0.0966517463791818 0.33082572700707 NF1/GLI3/CTNNB1/CTNNA1 4 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/998 33/18722 0.0966517463791818 0.33082572700707 IFI6/BCL2/HSPA1B/CTNNA1 4 GO:0043616 keratinocyte proliferation 5/998 46/18722 0.0966941312799824 0.33082572700707 YAP1/FERMT1/TP63/IRF6/FGFR2 5 GO:0045851 pH reduction 5/998 46/18722 0.0966941312799824 0.33082572700707 ATP6V1B1/CLN3/TMEM106B/BCL2/TTPA 5 GO:0014074 response to purine-containing compound 12/998 148/18722 0.0973397994404243 0.33281669474686 APP/HSP90B1/SLC6A4/AKAP9/HSPA5/HSPD1/BSG/EZR/P2RX4/CDO1/ASS1/HDAC2 12 GO:0007416 synapse assembly 14/998 179/18722 0.0974843242883612 0.333092707532417 APP/CDH1/DLG5/PPP1R9A/OBSL1/PLXNB1/NRCAM/EIF4G1/TPBG/CLSTN1/RYK/FZD5/SHANK2/VPS35 14 GO:0007252 I-kappaB phosphorylation 3/998 21/18722 0.0983588035929463 0.333245498740281 TLR3/ERC1/PRDX4 3 GO:0007617 mating behavior 3/998 21/18722 0.0983588035929463 0.333245498740281 APP/HEXB/HDAC2 3 GO:0010988 regulation of low-density lipoprotein particle clearance 3/998 21/18722 0.0983588035929463 0.333245498740281 CNPY2/MYLIP/ANXA2 3 GO:0030449 regulation of complement activation 3/998 21/18722 0.0983588035929463 0.333245498740281 CD46/CD55/CD59 3 GO:0038083 peptidyl-tyrosine autophosphorylation 3/998 21/18722 0.0983588035929463 0.333245498740281 EGFR/IGF1R/DDR1 3 GO:0046514 ceramide catabolic process 3/998 21/18722 0.0983588035929463 0.333245498740281 HEXB/HEXA/GM2A 3 GO:0046519 sphingoid metabolic process 3/998 21/18722 0.0983588035929463 0.333245498740281 PLPP3/SPTLC3/SGPP1 3 GO:0071498 cellular response to fluid shear stress 3/998 21/18722 0.0983588035929463 0.333245498740281 ASS1/PLEC/NFE2L2 3 GO:0072111 cell proliferation involved in kidney development 3/998 21/18722 0.0983588035929463 0.333245498740281 BMP7/GATA3/GPC3 3 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 3/998 21/18722 0.0983588035929463 0.333245498740281 MAGED1/LGR4/TACSTD2 3 GO:0097062 dendritic spine maintenance 3/998 21/18722 0.0983588035929463 0.333245498740281 IGF1R/HOMER1/VPS35 3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/998 21/18722 0.0983588035929463 0.333245498740281 PTTG1IP/MDM2/BCL2 3 GO:2000774 positive regulation of cellular senescence 3/998 21/18722 0.0983588035929463 0.333245498740281 PAWR/KRAS/YPEL3 3 GO:0010959 regulation of metal ion transport 28/998 406/18722 0.0985592514896922 0.333708075244931 ATP2B1/AHNAK/UTRN/AKAP9/ITGB1/GJA1/DLG1/FXYD3/ANO6/ANK3/ATP2B4/KCNN4/CAMK2G/DMD/PRSS8/SLC9A1/TSPAN13/HOMER1/FMR1/NEDD4/ACTN4/P2RX4/AHCYL1/CTNNB1/PKP2/BCL2/STOM/GPD1L 28 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 7/998 74/18722 0.0988258936686365 0.333961159122299 PARP1/CALR/YAP1/SKP2/ISL1/TP63/UFL1 7 GO:0048844 artery morphogenesis 7/998 74/18722 0.0988258936686365 0.333961159122299 LRP2/NRP1/NF1/GJA5/LRP1/FOLR1/TGFBR1 7 GO:0051881 regulation of mitochondrial membrane potential 7/998 74/18722 0.0988258936686365 0.333961159122299 IFI6/ARL6IP5/PARP1/SLC25A36/VCP/BCL2/PMAIP1 7 GO:0031638 zymogen activation 6/998 60/18722 0.0992145980183573 0.334841251618515 CTSL/ASPH/PERP/DHCR24/PRSS12/MMP14 6 GO:0042306 regulation of protein import into nucleus 6/998 60/18722 0.0992145980183573 0.334841251618515 CDH1/FERMT1/GLI3/TPR/MAPK14/UBR5 6 GO:0050806 positive regulation of synaptic transmission 13/998 164/18722 0.0993898505563704 0.335216026973392 EGFR/APP/MME/PPP1R9A/NCSTN/FMR1/SLC1A3/CLSTN1/EIF2AK4/PLK2/GSK3B/SHANK2/NSG1 13 GO:0006909 phagocytosis 22/998 308/18722 0.100351160888156 0.338239774691453 COLEC12/MET/ITGAV/ITGB1/TGM2/ANO6/LRP1/CALR/CD47/EIF2AK1/VAV3/ABCA1/SYT7/MYO7A/CLN3/YES1/KIAA1109/RAB31/TM9SF4/DOCK1/PTK2/ANXA3 22 GO:0043393 regulation of protein binding 15/998 196/18722 0.101754031295262 0.342746966059719 APP/NRP1/LRPAP1/LRP1/TGFBR3/TGFBR1/TCF7L2/GOLGA2/PLK2/AKTIP/ATP2A2/SPPL3/GSK3B/PHLDA2/ANXA2 15 GO:0006469 negative regulation of protein kinase activity 16/998 212/18722 0.102287662413417 0.344100441662661 BMP7/NR2F2/NF1/LRP5/PKIB/LATS2/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/PLEC/PDCD4/HEXIM1 16 GO:0043523 regulation of neuron apoptotic process 16/998 212/18722 0.102287662413417 0.344100441662661 NRP1/RASA1/NF1/LRP1/PARP1/TFAP2A/HSPD1/ERBB3/ISL1/CLN3/PRKCI/KRAS/CTNNB1/GATA3/BCL2/OXR1 16 GO:0060419 heart growth 9/998 104/18722 0.102949691408851 0.346104532418295 GJA1/TGFBR3/YAP1/DUSP9/TGFBR1/MAPK14/FGFR2/VGLL4/YY1 9 GO:0007595 lactation 5/998 47/18722 0.103724782954772 0.347145571671068 PRLR/CCND1/CDO1/DDR1/SLC29A1 5 GO:0010799 regulation of peptidyl-threonine phosphorylation 5/998 47/18722 0.103724782954772 0.347145571671068 APP/BMP7/EIF4G1/S1PR2/PARD3 5 GO:0031641 regulation of myelination 5/998 47/18722 0.103724782954772 0.347145571671068 DAG1/DLG1/DICER1/PARD3/CTNNB1 5 GO:0042311 vasodilation 5/998 47/18722 0.103724782954772 0.347145571671068 EGFR/ADRB1/GJA1/GJA5/EXT2 5 GO:0043114 regulation of vascular permeability 5/998 47/18722 0.103724782954772 0.347145571671068 FERMT2/TJP1/YES1/PLEC/OCLN 5 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 5/998 47/18722 0.103724782954772 0.347145571671068 HSPA5/NEDD4/ATF6/CHD6/NFE2L2 5 GO:0051972 regulation of telomerase activity 5/998 47/18722 0.103724782954772 0.347145571671068 MAP3K4/PKIB/HSP90AA1/CTNNB1/HNRNPA2B1 5 GO:0051453 regulation of intracellular pH 7/998 75/18722 0.104281761486442 0.348562789193799 CLN3/SLC9A1/TMEM106B/TM9SF4/TMEM165/BCL2/TTPA 7 GO:1902369 negative regulation of RNA catabolic process 7/998 75/18722 0.104281761486442 0.348562789193799 FUS/LRPPRC/FMR1/MAPK14/DHX36/SECISBP2/HNRNPU 7 GO:0001662 behavioral fear response 4/998 34/18722 0.105163421108869 0.349718612490067 DPP4/GJA1/EIF4G1/BCL2 4 GO:0032212 positive regulation of telomere maintenance via telomerase 4/998 34/18722 0.105163421108869 0.349718612490067 MAP3K4/PKIB/CTNNB1/TNKS2 4 GO:0043276 anoikis 4/998 34/18722 0.105163421108869 0.349718612490067 ITGB1/PTK2/BCL2/TLE1 4 GO:0044319 wound healing, spreading of cells 4/998 34/18722 0.105163421108869 0.349718612490067 FERMT1/FERMT2/DDR1/PHLDB2 4 GO:0051973 positive regulation of telomerase activity 4/998 34/18722 0.105163421108869 0.349718612490067 MAP3K4/PKIB/HSP90AA1/CTNNB1 4 GO:0055094 response to lipoprotein particle 4/998 34/18722 0.105163421108869 0.349718612490067 ITGB1/ABCA1/MIA3/PPARG 4 GO:0090505 epiboly involved in wound healing 4/998 34/18722 0.105163421108869 0.349718612490067 FERMT1/FERMT2/DDR1/PHLDB2 4 GO:2000758 positive regulation of peptidyl-lysine acetylation 4/998 34/18722 0.105163421108869 0.349718612490067 ISL1/RPS6KA5/BRD7/GATA3 4 GO:0030199 collagen fibril organization 6/998 61/18722 0.105366897558179 0.350172229249685 COL14A1/NF1/SERPINH1/TGFBR1/COL5A2/ANXA2 6 GO:0001101 response to acid chemical 11/998 135/18722 0.106324066066379 0.352903972620829 SLC38A9/DNMT1/ATP2B4/DNMT3A/UFL1/CDO1/ASS1/PLEC/COL5A2/ALAD/TOMM20 11 GO:0002687 positive regulation of leukocyte migration 11/998 135/18722 0.106324066066379 0.352903972620829 APP/ANO6/CALR/CD47/DOCK8/P2RX4/SWAP70/MIA3/JAM3/MMP14/PTK2 11 GO:0030307 positive regulation of cell growth 13/998 166/18722 0.106551889478302 0.353435460588446 EGFR/NRP1/GOLGA4/LRP1/USP47/CDKL5/SLC9A1/MACF1/EIF4G1/TGFBR1/MMP14/BCL2/MAP3K13 13 GO:0032392 DNA geometric change 8/998 90/18722 0.106766696005791 0.353474267499199 RAD50/ATRX/PURA/NAV2/DHX36/DDX1/CHD6/HNRNPA2B1 8 GO:0099175 regulation of postsynapse organization 8/998 90/18722 0.106766696005791 0.353474267499199 NRP2/PPP1R9A/EFNA1/CDKL5/HOMER1/SEMA3F/DHX36/VPS35 8 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 8/998 90/18722 0.106766696005791 0.353474267499199 GJA1/ADAMTS1/DNMT1/GNA12/MDM2/S1PR2/PPARG/PDCD4 8 GO:0055074 calcium ion homeostasis 31/998 460/18722 0.107041576515481 0.35415974080312 APP/ATP2B1/HSP90B1/ITGAV/GJA1/CD55/TGM2/CCDC47/LRP1/CD24/CALR/ATP13A3/GTF2I/ATP2B4/HEXB/MCOLN3/DMD/ATP6V1B1/CLN3/TRPV6/AFG3L2/P2RX4/SWAP70/BCAP31/TRIM24/TMEM165/GPR157/BCL2/ATP2A2/STC2/SPPL3 31 GO:0030218 erythrocyte differentiation 10/998 120/18722 0.107332521949061 0.354897464912 CDK6/TGFBR3/PRKDC/RCOR1/UFL1/MAPK14/GATA3/RBFOX2/HSPA1B/HSPA9 10 GO:0040029 regulation of gene expression, epigenetic 9/998 105/18722 0.107597700677255 0.355324222160624 DNMT1/TFAP2C/DNMT3A/TPR/MPHOSPH8/SMARCA5/CREBZF/HNRNPU/XIST 9 GO:2001022 positive regulation of response to DNA damage stimulus 9/998 105/18722 0.107597700677255 0.355324222160624 EGFR/PARP1/FUS/PRKDC/BCLAF1/FMR1/PLA2R1/RIF1/PMAIP1 9 GO:0031668 cellular response to extracellular stimulus 18/998 246/18722 0.108344309290917 0.355491280908617 SLC2A1/ATP2B1/HSPA5/CTSV/SKP2/MDM2/FOLR1/STK26/GABARAPL1/EIF4G1/EIF2AK4/TRIM24/SLC38A2/BCL2/PLEC/TNRC6A/PMAIP1/NFE2L2 18 GO:0002053 positive regulation of mesenchymal cell proliferation 3/998 22/18722 0.109589254082304 0.355491280908617 LRP5/FGFR2/CTNNB1 3 GO:0002320 lymphoid progenitor cell differentiation 3/998 22/18722 0.109589254082304 0.355491280908617 PRKDC/GATA3/BCL2 3 GO:0006359 regulation of transcription by RNA polymerase III 3/998 22/18722 0.109589254082304 0.355491280908617 ICE1/DHX36/ELL 3 GO:0007413 axonal fasciculation 3/998 22/18722 0.109589254082304 0.355491280908617 NRP1/NRCAM/RTN4 3 GO:0032891 negative regulation of organic acid transport 3/998 22/18722 0.109589254082304 0.355491280908617 SLC43A2/ARL6IP5/PLA2R1 3 GO:0034629 cellular protein-containing complex localization 3/998 22/18722 0.109589254082304 0.355491280908617 AKAP9/DLG1/EZR 3 GO:0035089 establishment of apical/basal cell polarity 3/998 22/18722 0.109589254082304 0.355491280908617 FAT1/PRKCI/OPHN1 3 GO:0035268 protein mannosylation 3/998 22/18722 0.109589254082304 0.355491280908617 DPY19L1/TMTC3/B4GAT1 3 GO:0036120 cellular response to platelet-derived growth factor stimulus 3/998 22/18722 0.109589254082304 0.355491280908617 YES1/ERRFI1/RDX 3 GO:0060444 branching involved in mammary gland duct morphogenesis 3/998 22/18722 0.109589254082304 0.355491280908617 LRP5/KDM5B/DDR1 3 GO:0060965 negative regulation of gene silencing by miRNA 3/998 22/18722 0.109589254082304 0.355491280908617 KCNQ1OT1/LIN28B/PPARG 3 GO:0071404 cellular response to low-density lipoprotein particle stimulus 3/998 22/18722 0.109589254082304 0.355491280908617 ITGB1/ABCA1/PPARG 3 GO:0106030 neuron projection fasciculation 3/998 22/18722 0.109589254082304 0.355491280908617 NRP1/NRCAM/RTN4 3 GO:2000773 negative regulation of cellular senescence 3/998 22/18722 0.109589254082304 0.355491280908617 CDK6/PRKDC/PLK2 3 GO:0045685 regulation of glial cell differentiation 7/998 76/18722 0.109896885622926 0.355491280908617 SPINT1/DAG1/NF1/IL6ST/DICER1/CTNNB1/HDAC2 7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 7/998 76/18722 0.109896885622926 0.355491280908617 PERP/PTTG1IP/MDM2/TP63/BCL2/PMAIP1/SHISA5 7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 13/998 167/18722 0.110245365365513 0.355491280908617 CDH1/TENM3/DSC2/DSC3/ITGB1/CADM1/DSG2/PCDH11X/OBSL1/FAT1/BSG/CLSTN1/PTPRM 13 GO:0043624 cellular protein complex disassembly 11/998 136/18722 0.110446354668385 0.355491280908617 LIMA1/SCIN/SWAP70/CAMSAP2/TRIOBP/RDX/EPS8/SPTAN1/SPTBN1/ADD3/MICAL3 11 GO:0042149 cellular response to glucose starvation 5/998 48/18722 0.111000834381491 0.355491280908617 SLC2A1/HSPA5/BCL2/PMAIP1/NFE2L2 5 GO:0042908 xenobiotic transport 5/998 48/18722 0.111000834381491 0.355491280908617 SLC2A1/GJA1/SLC22A5/ABCB1/TMEM30A 5 GO:0097720 calcineurin-mediated signaling 5/998 48/18722 0.111000834381491 0.355491280908617 NFAT5/ATP2B4/SLC9A1/SPPL3/GSK3B 5 GO:1903053 regulation of extracellular matrix organization 5/998 48/18722 0.111000834381491 0.355491280908617 DAG1/DPP4/LRP1/DDR1/PHLDB2 5 GO:0060113 inner ear receptor cell differentiation 6/998 62/18722 0.111712258600227 0.355491280908617 TRIP11/MCOLN3/MYO7A/ESRP1/TRIOBP/MYO6 6 GO:0060135 maternal process involved in female pregnancy 6/998 62/18722 0.111712258600227 0.355491280908617 GJA1/NR2F2/CTSV/ASH1L/BSG/STC2 6 GO:0038127 ERBB signaling pathway 10/998 121/18722 0.111754859489803 0.355491280908617 EGFR/EFEMP1/IFI6/GAB1/RPS6KA5/RTN4/GAREM1/ERRFI1/PTK2/CUL5 10 GO:0031669 cellular response to nutrient levels 16/998 215/18722 0.111918607489289 0.355491280908617 SLC2A1/ATP2B1/HSPA5/CTSV/MDM2/FOLR1/STK26/GABARAPL1/EIF4G1/EIF2AK4/TRIM24/SLC38A2/BCL2/TNRC6A/PMAIP1/NFE2L2 16 GO:0006354 DNA-templated transcription, elongation 8/998 91/18722 0.111924103334875 0.355491280908617 BRD4/SETD2/CTNNB1/TCERG1/NELFCD/ELL/HEXIM1/HNRNPU 8 GO:0006885 regulation of pH 8/998 91/18722 0.111924103334875 0.355491280908617 ATP6V1B1/CLN3/SLC9A1/TMEM106B/TM9SF4/TMEM165/BCL2/TTPA 8 GO:0055006 cardiac cell development 8/998 91/18722 0.111924103334875 0.355491280908617 TGFBR3/ISL1/OBSL1/PLEC/PDCD4/YY1/LMNA/HNRNPU 8 GO:1990874 vascular associated smooth muscle cell proliferation 8/998 91/18722 0.111924103334875 0.355491280908617 GJA1/ADAMTS1/DNMT1/GNA12/MDM2/S1PR2/PPARG/PDCD4 8 GO:2000278 regulation of DNA biosynthetic process 9/998 106/18722 0.112361768035743 0.355491280908617 GJA1/MAP3K4/DCP2/PKIB/HSP90AA1/CTNNB1/TNKS2/HNRNPU/HNRNPA2B1 9 GO:0051346 negative regulation of hydrolase activity 26/998 379/18722 0.113010012210738 0.355491280908617 ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/IFI6/AMOT/LRP1/SERPINH1/MDM2/USP47/SIAH2/DHCR24/BIRC6/PLA2R1/CAST/RDX/BOD1L1/ARFGEF1/GSK3B/GPC3/USP14/PEBP1/ANXA2 26 GO:0001765 membrane raft assembly 2/998 11/18722 0.113503919799783 0.355491280908617 FLOT2/ANXA2 2 GO:0002732 positive regulation of dendritic cell cytokine production 2/998 11/18722 0.113503919799783 0.355491280908617 DHX36/DDX1 2 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 2/998 11/18722 0.113503919799783 0.355491280908617 CD46/CD55 2 GO:0003093 regulation of glomerular filtration 2/998 11/18722 0.113503919799783 0.355491280908617 GJA1/GJA5 2 GO:0003139 secondary heart field specification 2/998 11/18722 0.113503919799783 0.355491280908617 LRP2/ISL1 2 GO:0003174 mitral valve development 2/998 11/18722 0.113503919799783 0.355491280908617 GJA5/EFNA1 2 GO:0003263 cardioblast proliferation 2/998 11/18722 0.113503919799783 0.355491280908617 ISL1/CTNNB1 2 GO:0003264 regulation of cardioblast proliferation 2/998 11/18722 0.113503919799783 0.355491280908617 ISL1/CTNNB1 2 GO:0006020 inositol metabolic process 2/998 11/18722 0.113503919799783 0.355491280908617 SLC5A3/ISYNA1 2 GO:0007042 lysosomal lumen acidification 2/998 11/18722 0.113503919799783 0.355491280908617 CLN3/TMEM106B 2 GO:0008611 ether lipid biosynthetic process 2/998 11/18722 0.113503919799783 0.355491280908617 FASN/FAR1 2 GO:0010887 negative regulation of cholesterol storage 2/998 11/18722 0.113503919799783 0.355491280908617 ABCA1/PPARG 2 GO:0018026 peptidyl-lysine monomethylation 2/998 11/18722 0.113503919799783 0.355491280908617 SMYD2/SETD2 2 GO:0019048 modulation by virus of host process 2/998 11/18722 0.113503919799783 0.355491280908617 DAG1/ANO6 2 GO:0030210 heparin biosynthetic process 2/998 11/18722 0.113503919799783 0.355491280908617 GLCE/EXT2 2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2/998 11/18722 0.113503919799783 0.355491280908617 ACADVL/ETFA 2 GO:0033625 positive regulation of integrin activation 2/998 11/18722 0.113503919799783 0.355491280908617 FERMT1/FERMT2 2 GO:0033632 regulation of cell-cell adhesion mediated by integrin 2/998 11/18722 0.113503919799783 0.355491280908617 DPP4/SWAP70 2 GO:0033690 positive regulation of osteoblast proliferation 2/998 11/18722 0.113503919799783 0.355491280908617 ITGAV/LRP5 2 GO:0034379 very-low-density lipoprotein particle assembly 2/998 11/18722 0.113503919799783 0.355491280908617 LPCAT3/ACSL3 2 GO:0034454 microtubule anchoring at centrosome 2/998 11/18722 0.113503919799783 0.355491280908617 PCM1/GSK3B 2 GO:0035457 cellular response to interferon-alpha 2/998 11/18722 0.113503919799783 0.355491280908617 TPR/GATA3 2 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 2/998 11/18722 0.113503919799783 0.355491280908617 EIF4G1/EIF2AK4 2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 2/998 11/18722 0.113503919799783 0.355491280908617 CHD6/NFE2L2 2 GO:0045654 positive regulation of megakaryocyte differentiation 2/998 11/18722 0.113503919799783 0.355491280908617 SCIN/RCOR1 2 GO:0045945 positive regulation of transcription by RNA polymerase III 2/998 11/18722 0.113503919799783 0.355491280908617 ICE1/ELL 2 GO:0046501 protoporphyrinogen IX metabolic process 2/998 11/18722 0.113503919799783 0.355491280908617 EIF2AK1/ALAD 2 GO:0046504 glycerol ether biosynthetic process 2/998 11/18722 0.113503919799783 0.355491280908617 FASN/FAR1 2 GO:0046929 negative regulation of neurotransmitter secretion 2/998 11/18722 0.113503919799783 0.355491280908617 PPP1R9A/FMR1 2 GO:0048715 negative regulation of oligodendrocyte differentiation 2/998 11/18722 0.113503919799783 0.355491280908617 NF1/CTNNB1 2 GO:0051561 positive regulation of mitochondrial calcium ion concentration 2/998 11/18722 0.113503919799783 0.355491280908617 TGM2/BCAP31 2 GO:0051574 positive regulation of histone H3-K9 methylation 2/998 11/18722 0.113503919799783 0.355491280908617 RIF1/LMNA 2 GO:0060767 epithelial cell proliferation involved in prostate gland development 2/998 11/18722 0.113503919799783 0.355491280908617 SERPINF1/CTNNB1 2 GO:0060900 embryonic camera-type eye formation 2/998 11/18722 0.113503919799783 0.355491280908617 TFAP2A/ALDH1A3 2 GO:0061029 eyelid development in camera-type eye 2/998 11/18722 0.113503919799783 0.355491280908617 TFAP2A/HDAC2 2 GO:0070417 cellular response to cold 2/998 11/18722 0.113503919799783 0.355491280908617 SLC9A1/EIF2AK4 2 GO:0070778 L-aspartate transmembrane transport 2/998 11/18722 0.113503919799783 0.355491280908617 SLC1A5/SLC1A3 2 GO:0070933 histone H4 deacetylation 2/998 11/18722 0.113503919799783 0.355491280908617 RCOR1/HDAC2 2 GO:0071492 cellular response to UV-A 2/998 11/18722 0.113503919799783 0.355491280908617 MME/OPN3 2 GO:0075522 IRES-dependent viral translational initiation 2/998 11/18722 0.113503919799783 0.355491280908617 EIF3A/DENR 2 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 2/998 11/18722 0.113503919799783 0.355491280908617 DNMT1/MPHOSPH8 2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 2/998 11/18722 0.113503919799783 0.355491280908617 SLC35B4/SLC35D1 2 GO:0097050 type B pancreatic cell apoptotic process 2/998 11/18722 0.113503919799783 0.355491280908617 CAST/TCF7L2 2 GO:0097384 cellular lipid biosynthetic process 2/998 11/18722 0.113503919799783 0.355491280908617 FASN/FAR1 2 GO:0140042 lipid droplet formation 2/998 11/18722 0.113503919799783 0.355491280908617 CDS1/SQLE 2 GO:1900112 regulation of histone H3-K9 trimethylation 2/998 11/18722 0.113503919799783 0.355491280908617 ATRX/LMNA 2 GO:1902667 regulation of axon guidance 2/998 11/18722 0.113503919799783 0.355491280908617 NRP1/MYCBP2 2 GO:1902915 negative regulation of protein polyubiquitination 2/998 11/18722 0.113503919799783 0.355491280908617 TRIM44/UBR5 2 GO:1903897 regulation of PERK-mediated unfolded protein response 2/998 11/18722 0.113503919799783 0.355491280908617 HSPA5/PTPN1 2 GO:1904181 positive regulation of membrane depolarization 2/998 11/18722 0.113503919799783 0.355491280908617 ANK3/PARP1 2 GO:1905668 positive regulation of protein localization to endosome 2/998 11/18722 0.113503919799783 0.355491280908617 EZR/RDX 2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/998 11/18722 0.113503919799783 0.355491280908617 HSPA5/ATF6 2 GO:2000615 regulation of histone H3-K9 acetylation 2/998 11/18722 0.113503919799783 0.355491280908617 ZNF451/GATA3 2 GO:0002209 behavioral defense response 4/998 35/18722 0.114002264511364 0.355806744937516 DPP4/GJA1/EIF4G1/BCL2 4 GO:0033280 response to vitamin D 4/998 35/18722 0.114002264511364 0.355806744937516 ATP2B1/BMP7/TRIM24/STC2 4 GO:0039694 viral RNA genome replication 4/998 35/18722 0.114002264511364 0.355806744937516 EEA1/MPHOSPH8/FMR1/TOP2B 4 GO:0090504 epiboly 4/998 35/18722 0.114002264511364 0.355806744937516 FERMT1/FERMT2/DDR1/PHLDB2 4 GO:0097421 liver regeneration 4/998 35/18722 0.114002264511364 0.355806744937516 EGFR/GLI3/SRSF5/CCND1 4 GO:0099173 postsynapse organization 13/998 168/18722 0.114013538456323 0.355806744937516 NRP2/NRP1/DLG1/IGF1R/PPP1R9A/EFNA1/CDKL5/WASF2/HOMER1/SEMA3F/DHX36/OPHN1/VPS35 13 GO:0055001 muscle cell development 14/998 184/18722 0.114849932143464 0.358202805090218 ITGB1/MYOF/DMD/ISL1/OBSL1/HOMER1/AFG3L2/ACTN4/BCL2/ATP2A2/PLEC/YY1/LMNA/HNRNPU 14 GO:1901983 regulation of protein acetylation 7/998 77/18722 0.115669292775629 0.360542911988991 ZNF451/ISL1/RPS6KA5/BRD7/GATA3/GSK3B/HDAC2 7 GO:0006936 muscle contraction 24/998 347/18722 0.116133370230695 0.361773464185237 DSP/ATP2B1/DSC2/ASPH/UTRN/AKAP9/GJA1/DLG1/GJA5/DSG2/MYOF/ATP2B4/DMD/CALD1/SLC9A1/HOMER1/SSPN/P2RX4/PKP2/GAA/PPP1R13L/ATP2A2/GPD1L/PABPN1 24 GO:0021761 limbic system development 9/998 107/18722 0.117240980357367 0.364788533042796 NRP2/NRP1/CDK6/ATP2B4/GLI3/FGFR2/ALDH1A3/GSK3B/ANXA3 9 GO:0032526 response to retinoic acid 9/998 107/18722 0.117240980357367 0.364788533042796 SLC6A4/SERPINF1/GJA1/YAP1/ABCA1/YES1/SUZ12/FGFR2/HDAC2 9 GO:1904589 regulation of protein import 6/998 63/18722 0.118247308722672 0.366789218970658 CDH1/FERMT1/GLI3/TPR/MAPK14/UBR5 6 GO:2000756 regulation of peptidyl-lysine acetylation 6/998 63/18722 0.118247308722672 0.366789218970658 ZNF451/ISL1/RPS6KA5/BRD7/GATA3/HDAC2 6 GO:0008038 neuron recognition 5/998 49/18722 0.118516263628328 0.366789218970658 APP/NRP1/NRCAM/BSG/RTN4 5 GO:0046580 negative regulation of Ras protein signal transduction 5/998 49/18722 0.118516263628328 0.366789218970658 MET/KANK1/RASA1/ITGB1/CCDC125 5 GO:0051932 synaptic transmission, GABAergic 5/998 49/18722 0.118516263628328 0.366789218970658 GABRE/CLN3/TPBG/KRAS/GABRA4 5 GO:0060986 endocrine hormone secretion 5/998 49/18722 0.118516263628328 0.366789218970658 GJA1/TRPV6/RAB11FIP1/GATA3/TMF1 5 GO:0072666 establishment of protein localization to vacuole 5/998 49/18722 0.118516263628328 0.366789218970658 VPS13A/NEDD4/GNPTAB/GCC2/ZFYVE16 5 GO:1901799 negative regulation of proteasomal protein catabolic process 5/998 49/18722 0.118516263628328 0.366789218970658 USP25/SMARCC1/OPHN1/ALAD/USP14 5 GO:1904752 regulation of vascular associated smooth muscle cell migration 5/998 49/18722 0.118516263628328 0.366789218970658 ADAMTS1/LRP1/GNA12/MDM2/NFE2L2 5 GO:0009952 anterior/posterior pattern specification 15/998 201/18722 0.118757156462098 0.36731701059752 WLS/PBX1/NR2F2/LRP5/PGAP1/PRKDC/GLI3/COBL/BPTF/TGFBR1/CTNNB1/FZD5/BHLHE41/GPC3/YY1 15 GO:0018105 peptidyl-serine phosphorylation 22/998 315/18722 0.119088452739803 0.368123630405275 EGFR/APP/TFRC/AKAP9/PRKDC/ATP2B4/DMD/RPS6KA5/EIF4G1/TLK1/PRKCI/LATS2/TGFBR1/NSD1/HSP90AA1/PKN2/MAPK14/BCL2/PLK2/GSK3B/GPD1L/MAP3K13 22 GO:0003283 atrial septum development 3/998 23/18722 0.121285437959603 0.371832807743446 GJA5/MDM2/ISL1 3 GO:0006929 substrate-dependent cell migration 3/998 23/18722 0.121285437959603 0.371832807743446 NRP1/CD2AP/OPHN1 3 GO:0010888 negative regulation of lipid storage 3/998 23/18722 0.121285437959603 0.371832807743446 ITGAV/ABCA1/PPARG 3 GO:0019430 removal of superoxide radicals 3/998 23/18722 0.121285437959603 0.371832807743446 BMP7/SOD3/NFE2L2 3 GO:0021544 subpallium development 3/998 23/18722 0.121285437959603 0.371832807743446 GLI3/ALDH1A3/SECISBP2 3 GO:0021884 forebrain neuron development 3/998 23/18722 0.121285437959603 0.371832807743446 NRP2/NRP1/FGFR2 3 GO:0030325 adrenal gland development 3/998 23/18722 0.121285437959603 0.371832807743446 PBX1/NF1/ARID5B 3 GO:0030539 male genitalia development 3/998 23/18722 0.121285437959603 0.371832807743446 LGR4/DHCR24/CTNNB1 3 GO:0036119 response to platelet-derived growth factor 3/998 23/18722 0.121285437959603 0.371832807743446 YES1/ERRFI1/RDX 3 GO:0036303 lymph vessel morphogenesis 3/998 23/18722 0.121285437959603 0.371832807743446 SVEP1/PTPN14/LGALS8 3 GO:0051882 mitochondrial depolarization 3/998 23/18722 0.121285437959603 0.371832807743446 IFI6/PARP1/BCL2 3 GO:0060396 growth hormone receptor signaling pathway 3/998 23/18722 0.121285437959603 0.371832807743446 LEPROT/PTPN1/PTK2 3 GO:0090335 regulation of brown fat cell differentiation 3/998 23/18722 0.121285437959603 0.371832807743446 BMP7/MAPK14/HNRNPU 3 GO:1900273 positive regulation of long-term synaptic potentiation 3/998 23/18722 0.121285437959603 0.371832807743446 APP/MME/EIF2AK4 3 GO:0008306 associative learning 7/998 78/18722 0.121596772364451 0.372568514386619 APP/ITGB1/NF1/CLN3/TPBG/KRAS/MEIS2 7 GO:0016053 organic acid biosynthetic process 22/998 316/18722 0.121929133512857 0.373367745495968 ACSS1/DEGS1/SLC27A2/HACD3/MGST3/ATP2B4/MTR/ACADVL/CLN3/OSBPL9/SLC1A3/CDO1/AASDHPPT/ALDH18A1/ALDH1A3/ASS1/ACSL3/SERINC3/FASN/QKI/BCAT1/TECR 22 GO:0016051 carbohydrate biosynthetic process 15/998 202/18722 0.12234703153128 0.374051744807681 AGL/DDB1/ISYNA1/CLTC/SLC35B4/FUT8/B4GALT1/UGP2/B3GNT3/SORBS1/FAM3C/B3GNT2/RANBP2/EXT2/GSK3B 15 GO:0007589 body fluid secretion 8/998 93/18722 0.122636103139567 0.374051744807681 EGFR/PRLR/KCNN4/CCND1/CDO1/DDR1/SLC29A1/ANXA2 8 GO:0106027 neuron projection organization 8/998 93/18722 0.122636103139567 0.374051744807681 APP/IGF1R/PPP1R9A/EFNA1/HOMER1/DHX36/GSK3B/VPS35 8 GO:1901796 regulation of signal transduction by p53 class mediator 8/998 93/18722 0.122636103139567 0.374051744807681 PTTG1IP/MDM2/SMYD2/PLA2R1/TRIM24/BCL2/PMAIP1/HEXIM1 8 GO:0003203 endocardial cushion morphogenesis 4/998 36/18722 0.123155516055239 0.374051744807681 BMP7/MDM2/ISL1/TGFBR1 4 GO:0010762 regulation of fibroblast migration 4/998 36/18722 0.123155516055239 0.374051744807681 ITGB1/GNA12/CLN3/PTK2 4 GO:0046466 membrane lipid catabolic process 4/998 36/18722 0.123155516055239 0.374051744807681 HEXB/FUCA1/HEXA/GM2A 4 GO:0051385 response to mineralocorticoid 4/998 36/18722 0.123155516055239 0.374051744807681 ATP2B1/PARP1/CCND1/KRAS 4 GO:0060251 regulation of glial cell proliferation 4/998 36/18722 0.123155516055239 0.374051744807681 EGFR/UFL1/PRKCI/DICER1 4 GO:0070670 response to interleukin-4 4/998 36/18722 0.123155516055239 0.374051744807681 HSPA5/GATA3/FASN/ALAD 4 GO:0071402 cellular response to lipoprotein particle stimulus 4/998 36/18722 0.123155516055239 0.374051744807681 ITGB1/ABCA1/MIA3/PPARG 4 GO:0090313 regulation of protein targeting to membrane 4/998 36/18722 0.123155516055239 0.374051744807681 TCAF1/ANK3/MYO1C/STOM 4 GO:1903539 protein localization to postsynaptic membrane 4/998 36/18722 0.123155516055239 0.374051744807681 DAG1/DLG1/CLSTN1/NSG1 4 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/998 36/18722 0.123155516055239 0.374051744807681 HUWE1/LEPROT/NPEPPS/FZD5 4 GO:0016050 vesicle organization 21/998 300/18722 0.123412814368063 0.374615292916081 EEA1/FNBP1L/VAV3/ABCA1/SYT7/HOOK2/SEC31A/MYO7A/CLN3/TMED9/CD2AP/PRKCI/MIA3/UVRAG/USO1/BCL2/AKTIP/ZFYVE16/TMF1/TFG/ANXA2 21 GO:0022409 positive regulation of cell-cell adhesion 20/998 284/18722 0.124817208033327 0.378456904685065 CD46/BMP7/DPP4/TFRC/NFAT5/CD55/ANK3/CD24/GCNT2/CD47/PLPP3/IL6ST/HSPD1/GLI3/DOCK8/TJP1/YES1/GATA3/FLOT2/PNP 20 GO:0016126 sterol biosynthetic process 6/998 64/18722 0.124968340102864 0.378456904685065 LPCAT3/CYB5R1/MBTPS1/DHCR24/FDFT1/SQLE 6 GO:1900076 regulation of cellular response to insulin stimulus 6/998 64/18722 0.124968340102864 0.378456904685065 ATP2B1/KANK1/SORBS1/PTPN1/USO1/MYO1C 6 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 6/998 64/18722 0.124968340102864 0.378456904685065 USP25/EFNA1/SMARCC1/OPHN1/ALAD/USP14 6 GO:0009615 response to virus 25/998 367/18722 0.125083481010565 0.378586002525311 ITGB8/IFI6/CDK6/IL10RB/NCBP3/SKP2/EXOC1/TRIM44/DDX17/TLR3/PUM1/FMR1/ANKRD17/SETD2/CREBZF/HSP90AA1/EIF2AK4/MAPK14/DHX36/DDX1/GATA3/BCL2/LGALS8/SERINC3/PMAIP1 25 GO:0007632 visual behavior 5/998 50/18722 0.126264547442891 0.380616167551577 APP/ITGB1/NF1/KRAS/MEIS2 5 GO:0018023 peptidyl-lysine trimethylation 5/998 50/18722 0.126264547442891 0.380616167551577 BRD4/ATRX/TET2/SETD2/LMNA 5 GO:0071709 membrane assembly 5/998 50/18722 0.126264547442891 0.380616167551577 ANK3/REEP3/SPTBN1/FLOT2/ANXA2 5 GO:1903747 regulation of establishment of protein localization to mitochondrion 5/998 50/18722 0.126264547442891 0.380616167551577 LMAN1/HUWE1/LEPROT/NPEPPS/FZD5 5 GO:1904036 negative regulation of epithelial cell apoptotic process 5/998 50/18722 0.126264547442891 0.380616167551577 YAP1/CAST/TCF7L2/GATA3/NFE2L2 5 GO:1904738 vascular associated smooth muscle cell migration 5/998 50/18722 0.126264547442891 0.380616167551577 ADAMTS1/LRP1/GNA12/MDM2/NFE2L2 5 GO:2000677 regulation of transcription regulatory region DNA binding 5/998 50/18722 0.126264547442891 0.380616167551577 PARP1/MSX2/NSD1/CTNNB1/GATA3 5 GO:0042886 amide transport 21/998 301/18722 0.12639752717201 0.380797166396459 EGFR/LRP2/DPP4/GJA1/LRP5/FAM3B/LRP1/SLC19A1/CCDC186/SLC13A3/CAMK2G/FOLR1/ABCA1/ISL1/SYT7/SLC16A1/PLEKHA8/SLC5A6/TCF7L2/ABCB1/SGPP1 21 GO:0010951 negative regulation of endopeptidase activity 18/998 252/18722 0.127299723167994 0.383294033829351 ITIH5/APP/SPINT1/APLP2/CRIM1/SERPINF1/SPINT2/IFI6/SERPINH1/MDM2/USP47/SIAH2/DHCR24/BIRC6/CAST/USP14/PEBP1/ANXA2 18 GO:0000245 spliceosomal complex assembly 7/998 79/18722 0.127676884658662 0.383986759679074 SF1/SRSF5/RBM5/SF3B1/DDX1/SNRNP200/LUC7L3 7 GO:0006446 regulation of translational initiation 7/998 79/18722 0.127676884658662 0.383986759679074 EIF2AK1/TPR/EIF4G1/FMR1/EIF2AK4/DDX1/AGO2 7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 8/998 94/18722 0.128187523524962 0.385300552863458 EGFR/NR2F2/CCND1/LATS2/CDKN1C/IPO7/CDK7/HEXIM1 8 GO:1901214 regulation of neuron death 22/998 319/18722 0.130696039064325 0.385688800678147 NRP1/RASA1/SERPINF1/NF1/LRP1/PARP1/TFAP2A/HSPD1/ERBB3/ISL1/CLN3/DHCR24/EIF4G1/PRKCI/KRAS/CTNNB1/GATA3/BCL2/GSK3B/OXR1/VPS35/TMEM259 22 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/998 12/18722 0.131577216716746 0.385688800678147 HSPA5/SEC63 2 GO:0010623 programmed cell death involved in cell development 2/998 12/18722 0.131577216716746 0.385688800678147 PRKDC/BCL2 2 GO:0015780 nucleotide-sugar transmembrane transport 2/998 12/18722 0.131577216716746 0.385688800678147 SLC35B4/SLC35D1 2 GO:0021978 telencephalon regionalization 2/998 12/18722 0.131577216716746 0.385688800678147 ADGRG1/TRA2B 2 GO:0030202 heparin metabolic process 2/998 12/18722 0.131577216716746 0.385688800678147 GLCE/EXT2 2 GO:0030238 male sex determination 2/998 12/18722 0.131577216716746 0.385688800678147 SF1/MAP3K4 2 GO:0033127 regulation of histone phosphorylation 2/998 12/18722 0.131577216716746 0.385688800678147 RPS6KA5/FMR1 2 GO:0033629 negative regulation of cell adhesion mediated by integrin 2/998 12/18722 0.131577216716746 0.385688800678147 SWAP70/JAM3 2 GO:0034086 maintenance of sister chromatid cohesion 2/998 12/18722 0.131577216716746 0.385688800678147 ATRX/NIPBL 2 GO:0034088 maintenance of mitotic sister chromatid cohesion 2/998 12/18722 0.131577216716746 0.385688800678147 ATRX/NIPBL 2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 2/998 12/18722 0.131577216716746 0.385688800678147 COL4A2/DDR1 2 GO:0042118 endothelial cell activation 2/998 12/18722 0.131577216716746 0.385688800678147 TGFBR1/P2RX4 2 GO:0043696 dedifferentiation 2/998 12/18722 0.131577216716746 0.385688800678147 NCOA3/CDK6 2 GO:0043697 cell dedifferentiation 2/998 12/18722 0.131577216716746 0.385688800678147 NCOA3/CDK6 2 GO:0046831 regulation of RNA export from nucleus 2/998 12/18722 0.131577216716746 0.385688800678147 TPR/SETD2 2 GO:0060019 radial glial cell differentiation 2/998 12/18722 0.131577216716746 0.385688800678147 GLI3/GPR157 2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/998 12/18722 0.131577216716746 0.385688800678147 LRP1/PPARG 2 GO:0060442 branching involved in prostate gland morphogenesis 2/998 12/18722 0.131577216716746 0.385688800678147 BMP7/FGFR2 2 GO:0060788 ectodermal placode formation 2/998 12/18722 0.131577216716746 0.385688800678147 CTNNB1/HDAC2 2 GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/998 12/18722 0.131577216716746 0.385688800678147 BMP7/FOLR1 2 GO:0061308 cardiac neural crest cell development involved in heart development 2/998 12/18722 0.131577216716746 0.385688800678147 BMP7/FOLR1 2 GO:0061430 bone trabecula morphogenesis 2/998 12/18722 0.131577216716746 0.385688800678147 FBN2/PLXNB1 2 GO:0070213 protein auto-ADP-ribosylation 2/998 12/18722 0.131577216716746 0.385688800678147 PARP1/TNKS2 2 GO:0070493 thrombin-activated receptor signaling pathway 2/998 12/18722 0.131577216716746 0.385688800678147 MET/IQGAP2 2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 2/998 12/18722 0.131577216716746 0.385688800678147 BRD4/CDK7 2 GO:0071287 cellular response to manganese ion 2/998 12/18722 0.131577216716746 0.385688800678147 APP/HSPA5 2 GO:0071635 negative regulation of transforming growth factor beta production 2/998 12/18722 0.131577216716746 0.385688800678147 CD24/CD2AP 2 GO:0071697 ectodermal placode morphogenesis 2/998 12/18722 0.131577216716746 0.385688800678147 CTNNB1/HDAC2 2 GO:0071872 cellular response to epinephrine stimulus 2/998 12/18722 0.131577216716746 0.385688800678147 ATP2B4/SLC9A1 2 GO:0072520 seminiferous tubule development 2/998 12/18722 0.131577216716746 0.385688800678147 ADGRG1/ATRX 2 GO:0072711 cellular response to hydroxyurea 2/998 12/18722 0.131577216716746 0.385688800678147 ATRX/FMR1 2 GO:0090085 regulation of protein deubiquitination 2/998 12/18722 0.131577216716746 0.385688800678147 VCP/OTUD4 2 GO:0090385 phagosome-lysosome fusion 2/998 12/18722 0.131577216716746 0.385688800678147 SYT7/CLN3 2 GO:0090557 establishment of endothelial intestinal barrier 2/998 12/18722 0.131577216716746 0.385688800678147 TJP1/FASN 2 GO:0098974 postsynaptic actin cytoskeleton organization 2/998 12/18722 0.131577216716746 0.385688800678147 PPP1R9A/WASF2 2 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/998 12/18722 0.131577216716746 0.385688800678147 MET/PAWR 2 GO:1901503 ether biosynthetic process 2/998 12/18722 0.131577216716746 0.385688800678147 FASN/FAR1 2 GO:1902950 regulation of dendritic spine maintenance 2/998 12/18722 0.131577216716746 0.385688800678147 HOMER1/VPS35 2 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 2/998 12/18722 0.131577216716746 0.385688800678147 RYK/CTNNB1 2 GO:1905214 regulation of RNA binding 2/998 12/18722 0.131577216716746 0.385688800678147 EIF4G1/FMR1 2 GO:1905666 regulation of protein localization to endosome 2/998 12/18722 0.131577216716746 0.385688800678147 EZR/RDX 2 GO:2000009 negative regulation of protein localization to cell surface 2/998 12/18722 0.131577216716746 0.385688800678147 LEPROT/GOPC 2 GO:2000628 regulation of miRNA metabolic process 2/998 12/18722 0.131577216716746 0.385688800678147 KCNQ1OT1/LIN28B 2 GO:0033673 negative regulation of kinase activity 17/998 237/18722 0.131792933340021 0.385688800678147 BMP7/NR2F2/NF1/LRP5/PKIB/LATS2/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/PLEC/PDCD4/HEXIM1/HNRNPU 17 GO:0015909 long-chain fatty acid transport 6/998 65/18722 0.131871326583147 0.385688800678147 SLC2A1/SLC27A2/PLA2R1/PPARG/CPT2/ACSL3 6 GO:0045682 regulation of epidermis development 6/998 65/18722 0.131871326583147 0.385688800678147 NCOA3/TP63/ESRP1/ERRFI1/GRHL1/SGPP1 6 GO:0070936 protein K48-linked ubiquitination 6/998 65/18722 0.131871326583147 0.385688800678147 SKP2/UBE2H/TRIM44/UBR5/TTC3/UBE2G2 6 GO:0033120 positive regulation of RNA splicing 4/998 37/18722 0.132609710813448 0.385688800678147 SRSF5/TRA2B/SLC38A2/POLR2A 4 GO:0043687 post-translational protein modification 4/998 37/18722 0.132609710813448 0.385688800678147 STT3B/P3H1/STT3A/SUMF1 4 GO:0050775 positive regulation of dendrite morphogenesis 4/998 37/18722 0.132609710813448 0.385688800678147 CUX1/OBSL1/CDKL5/DHX36 4 GO:0051294 establishment of spindle orientation 4/998 37/18722 0.132609710813448 0.385688800678147 ITGB1/GJA1/MAP4/GPSM2 4 GO:0060416 response to growth hormone 4/998 37/18722 0.132609710813448 0.385688800678147 LEPROT/PTPN1/PTK2/ASS1 4 GO:0062237 protein localization to postsynapse 4/998 37/18722 0.132609710813448 0.385688800678147 DAG1/DLG1/CLSTN1/NSG1 4 GO:0071985 multivesicular body sorting pathway 4/998 37/18722 0.132609710813448 0.385688800678147 EXPH5/LEPROT/UVRAG/VCP 4 GO:0001702 gastrulation with mouth forming second 3/998 24/18722 0.133413900406959 0.385688800678147 LRP5/AMOT/CTNNB1 3 GO:0002726 positive regulation of T cell cytokine production 3/998 24/18722 0.133413900406959 0.385688800678147 CD55/FZD5/GATA3 3 GO:0010226 response to lithium ion 3/998 24/18722 0.133413900406959 0.385688800678147 CDH1/CALR/NFE2L2 3 GO:0010288 response to lead ion 3/998 24/18722 0.133413900406959 0.385688800678147 APP/DNMT3A/ALAD 3 GO:0032528 microvillus organization 3/998 24/18722 0.133413900406959 0.385688800678147 KLF5/STK26/EZR 3 GO:0060149 negative regulation of posttranscriptional gene silencing 3/998 24/18722 0.133413900406959 0.385688800678147 KCNQ1OT1/LIN28B/PPARG 3 GO:0060561 apoptotic process involved in morphogenesis 3/998 24/18722 0.133413900406959 0.385688800678147 BMP7/LRP5/FZD5 3 GO:0060967 negative regulation of gene silencing by RNA 3/998 24/18722 0.133413900406959 0.385688800678147 KCNQ1OT1/LIN28B/PPARG 3 GO:0061162 establishment of monopolar cell polarity 3/998 24/18722 0.133413900406959 0.385688800678147 FAT1/PRKCI/OPHN1 3 GO:0071378 cellular response to growth hormone stimulus 3/998 24/18722 0.133413900406959 0.385688800678147 LEPROT/PTPN1/PTK2 3 GO:0071577 zinc ion transmembrane transport 3/998 24/18722 0.133413900406959 0.385688800678147 SLC39A10/SLC39A7/SLC39A1 3 GO:1901984 negative regulation of protein acetylation 3/998 24/18722 0.133413900406959 0.385688800678147 ZNF451/GSK3B/HDAC2 3 GO:2000353 positive regulation of endothelial cell apoptotic process 3/998 24/18722 0.133413900406959 0.385688800678147 ANO6/PRKCI/PDCD4 3 GO:2000679 positive regulation of transcription regulatory region DNA binding 3/998 24/18722 0.133413900406959 0.385688800678147 PARP1/CTNNB1/GATA3 3 GO:0050764 regulation of phagocytosis 8/998 95/18722 0.133866836806423 0.386361771583698 ITGAV/TGM2/ANO6/LRP1/CALR/CD47/SYT7/RAB31 8 GO:0048145 regulation of fibroblast proliferation 7/998 80/18722 0.13390696935399 0.386361771583698 CDK6/NF1/PRKDC/PAWR/CTNNB1/WAPL/ANXA2 7 GO:0006694 steroid biosynthetic process 13/998 173/18722 0.133963507042099 0.386361771583698 SLC27A2/PBX1/PRLR/LPCAT3/CYB5R1/SF1/HSD17B1/MBTPS1/DHCR24/OSBPL9/FDFT1/ACBD3/SQLE 13 GO:0009948 anterior/posterior axis specification 5/998 51/18722 0.134238700182499 0.386361771583698 WLS/PGAP1/CTNNB1/FZD5/GPC3 5 GO:0032964 collagen biosynthetic process 5/998 51/18722 0.134238700182499 0.386361771583698 SUCO/SERPINH1/TRAM2/ERRFI1/HDAC2 5 GO:0048013 ephrin receptor signaling pathway 5/998 51/18722 0.134238700182499 0.386361771583698 RASA1/EPHB4/EFNA1/YES1/PTK2 5 GO:0051293 establishment of spindle localization 5/998 51/18722 0.134238700182499 0.386361771583698 ITGB1/GJA1/DYNC1H1/MAP4/GPSM2 5 GO:0065002 intracellular protein transmembrane transport 5/998 51/18722 0.134238700182499 0.386361771583698 HSPA5/HSPD1/TRAM2/SEC63/TOMM20 5 GO:0018209 peptidyl-serine modification 23/998 338/18722 0.137671630085341 0.396024011391496 EGFR/APP/TFRC/AKAP9/PARP1/PRKDC/ATP2B4/DMD/RPS6KA5/EIF4G1/TLK1/PRKCI/LATS2/TGFBR1/NSD1/HSP90AA1/PKN2/MAPK14/BCL2/PLK2/GSK3B/GPD1L/MAP3K13 23 GO:0099111 microtubule-based transport 14/998 190/18722 0.137935133106453 0.396563507681052 APP/DST/DYNC1H1/ARHGAP21/CLN3/LRPPRC/SFPQ/RAB6A/PURA/PCM1/SUN1/FLOT2/ARMCX3/HNRNPU 14 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 6/998 66/18722 0.138951941232986 0.39904735158274 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0016444 somatic cell DNA recombination 6/998 66/18722 0.138951941232986 0.39904735158274 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0015914 phospholipid transport 8/998 96/18722 0.139672055155634 0.400674615366793 ATP10D/ANO6/KCNN4/ABCA1/PLEKHA8/TMEM30B/ABCB1/TMEM30A 8 GO:0055017 cardiac muscle tissue growth 8/998 96/18722 0.139672055155634 0.400674615366793 GJA1/TGFBR3/YAP1/TGFBR1/MAPK14/FGFR2/VGLL4/YY1 8 GO:0008589 regulation of smoothened signaling pathway 7/998 81/18722 0.14028415455087 0.401108198745944 DLG5/GLI3/VCP/FGFR2/HERC4/GPC3/CTNNA1 7 GO:0030641 regulation of cellular pH 7/998 81/18722 0.14028415455087 0.401108198745944 CLN3/SLC9A1/TMEM106B/TM9SF4/TMEM165/BCL2/TTPA 7 GO:0044773 mitotic DNA damage checkpoint signaling 7/998 81/18722 0.14028415455087 0.401108198745944 FOXO4/PRKDC/MDM2/CCND1/PLK2/XPC/PPP1R10 7 GO:0048144 fibroblast proliferation 7/998 81/18722 0.14028415455087 0.401108198745944 CDK6/NF1/PRKDC/PAWR/CTNNB1/WAPL/ANXA2 7 GO:0048708 astrocyte differentiation 7/998 81/18722 0.14028415455087 0.401108198745944 EGFR/APP/CDK6/NF1/LRP1/IL6ST/KRAS 7 GO:2001021 negative regulation of response to DNA damage stimulus 7/998 81/18722 0.14028415455087 0.401108198745944 PTTG1IP/MDM2/USP47/RIF1/BCL2/UBR5/PPP1R10 7 GO:0051224 negative regulation of protein transport 10/998 127/18722 0.140393585142141 0.401201372757042 LMAN1/FRMD4A/FERMT1/ERLEC1/ERP29/NDFIP2/GOPC/RAB11FIP1/LYPLA1/UBE2G2 10 GO:0048713 regulation of oligodendrocyte differentiation 4/998 38/18722 0.142350780089363 0.406418685630438 DAG1/NF1/CTNNB1/HDAC2 4 GO:0030514 negative regulation of BMP signaling pathway 5/998 52/18722 0.142431312777376 0.406418685630438 FBN1/LRP2/CRIM1/TRIM33/PPARG 5 GO:0048771 tissue remodeling 13/998 175/18722 0.142452824114864 0.406418685630438 EGFR/TFRC/GJA1/LGR4/NF1/LRP5/TGM2/SUCO/MDM2/SYT7/CTNNB1/MMP14/LTBP3 13 GO:0032886 regulation of microtubule-based process 17/998 240/18722 0.142533365896861 0.406426380856097 MET/CLIP1/AKAP9/CLTC/DYNC1H1/TPR/KLHL42/MACF1/CAMSAP2/GNAI1/PLK2/OCLN/HSPA1B/GSK3B/GPSM2/PHLDB2/HNRNPU 17 GO:1901222 regulation of NIK/NF-kappaB signaling 9/998 112/18722 0.143323405555088 0.408456059172005 EGFR/APP/BMP7/NFAT5/CALR/TRIM44/TLR3/ACTN4/PDCD4 9 GO:0002573 myeloid leukocyte differentiation 15/998 208/18722 0.145189685662697 0.411868801179126 FBN1/APP/ITGB8/TFRC/CDK6/PARP1/EIF2AK1/TLR3/PPARG/MAPK14/CTNNB1/GATA3/FASN/GPC3/ANXA2 15 GO:0070167 regulation of biomineral tissue development 8/998 97/18722 0.145601039140472 0.411868801179126 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ANKH/LTBP3/ATRAID 8 GO:0120162 positive regulation of cold-induced thermogenesis 8/998 97/18722 0.145601039140472 0.411868801179126 ADRB1/GJA1/IGF1R/PRLR/DYNC1H1/ESRRG/CPT2/GNAS 8 GO:0010996 response to auditory stimulus 3/998 25/18722 0.145940869983027 0.411868801179126 USP53/SLC1A3/XPC 3 GO:0021846 cell proliferation in forebrain 3/998 25/18722 0.145940869983027 0.411868801179126 GLI3/FGFR2/PCM1 3 GO:0033622 integrin activation 3/998 25/18722 0.145940869983027 0.411868801179126 FERMT1/FERMT2/JAM3 3 GO:0035336 long-chain fatty-acyl-CoA metabolic process 3/998 25/18722 0.145940869983027 0.411868801179126 ACSL3/FAR1/TECR 3 GO:0045109 intermediate filament organization 3/998 25/18722 0.145940869983027 0.411868801179126 DSP/PKP2/PLEC 3 GO:0048143 astrocyte activation 3/998 25/18722 0.145940869983027 0.411868801179126 EGFR/APP/LRP1 3 GO:0060740 prostate gland epithelium morphogenesis 3/998 25/18722 0.145940869983027 0.411868801179126 BMP7/TP63/FGFR2 3 GO:0061339 establishment or maintenance of monopolar cell polarity 3/998 25/18722 0.145940869983027 0.411868801179126 FAT1/PRKCI/OPHN1 3 GO:0062009 secondary palate development 3/998 25/18722 0.145940869983027 0.411868801179126 ITGB8/DLG1/TGFBR3 3 GO:0071450 cellular response to oxygen radical 3/998 25/18722 0.145940869983027 0.411868801179126 BMP7/SOD3/NFE2L2 3 GO:0071451 cellular response to superoxide 3/998 25/18722 0.145940869983027 0.411868801179126 BMP7/SOD3/NFE2L2 3 GO:0072202 cell differentiation involved in metanephros development 3/998 25/18722 0.145940869983027 0.411868801179126 LGR4/YAP1/CTNNB1 3 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 3/998 25/18722 0.145940869983027 0.411868801179126 GJA1/GJA5/PKP2 3 GO:1901798 positive regulation of signal transduction by p53 class mediator 3/998 25/18722 0.145940869983027 0.411868801179126 PLA2R1/PMAIP1/HEXIM1 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/998 25/18722 0.145940869983027 0.411868801179126 ADAMTS1/LRP1/MDM2 3 GO:0016445 somatic diversification of immunoglobulins 6/998 67/18722 0.14620557430452 0.411947816213652 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0042490 mechanoreceptor differentiation 6/998 67/18722 0.14620557430452 0.411947816213652 TRIP11/MCOLN3/MYO7A/ESRP1/TRIOBP/MYO6 6 GO:0048814 regulation of dendrite morphogenesis 6/998 67/18722 0.14620557430452 0.411947816213652 CUX1/OBSL1/CDKL5/NEDD4/DHX36/GSK3B 6 GO:0033135 regulation of peptidyl-serine phosphorylation 11/998 144/18722 0.146644310992314 0.412961136834342 EGFR/APP/TFRC/AKAP9/ATP2B4/DMD/EIF4G1/NSD1/HSP90AA1/BCL2/GPD1L 11 GO:0001768 establishment of T cell polarity 2/998 13/18722 0.150243970416979 0.413943941713481 DOCK8/FLOT2 2 GO:0001778 plasma membrane repair 2/998 13/18722 0.150243970416979 0.413943941713481 MYOF/SYT7 2 GO:0003334 keratinocyte development 2/998 13/18722 0.150243970416979 0.413943941713481 EXPH5/PLEC 2 GO:0007183 SMAD protein complex assembly 2/998 13/18722 0.150243970416979 0.413943941713481 PARP1/EID2 2 GO:0007494 midgut development 2/998 13/18722 0.150243970416979 0.413943941713481 EGFR/ASS1 2 GO:0009437 carnitine metabolic process 2/998 13/18722 0.150243970416979 0.413943941713481 CROT/CPT2 2 GO:0010635 regulation of mitochondrial fusion 2/998 13/18722 0.150243970416979 0.413943941713481 TFRC/HUWE1 2 GO:0010917 negative regulation of mitochondrial membrane potential 2/998 13/18722 0.150243970416979 0.413943941713481 ARL6IP5/PMAIP1 2 GO:0016246 RNA interference 2/998 13/18722 0.150243970416979 0.413943941713481 DICER1/AGO2 2 GO:0021514 ventral spinal cord interneuron differentiation 2/998 13/18722 0.150243970416979 0.413943941713481 LMO4/GLI3 2 GO:0021554 optic nerve development 2/998 13/18722 0.150243970416979 0.413943941713481 GLI3/NAV2 2 GO:0030497 fatty acid elongation 2/998 13/18722 0.150243970416979 0.413943941713481 HACD3/TECR 2 GO:0031053 primary miRNA processing 2/998 13/18722 0.150243970416979 0.413943941713481 LIN28B/HNRNPA2B1 2 GO:0032530 regulation of microvillus organization 2/998 13/18722 0.150243970416979 0.413943941713481 KLF5/EZR 2 GO:0034112 positive regulation of homotypic cell-cell adhesion 2/998 13/18722 0.150243970416979 0.413943941713481 ANK3/IL6ST 2 GO:0034982 mitochondrial protein processing 2/998 13/18722 0.150243970416979 0.413943941713481 AFG3L2/YME1L1 2 GO:0042659 regulation of cell fate specification 2/998 13/18722 0.150243970416979 0.413943941713481 LMO4/ESRP1 2 GO:0042761 very long-chain fatty acid biosynthetic process 2/998 13/18722 0.150243970416979 0.413943941713481 HACD3/TECR 2 GO:0043970 histone H3-K9 acetylation 2/998 13/18722 0.150243970416979 0.413943941713481 ZNF451/GATA3 2 GO:0044794 positive regulation by host of viral process 2/998 13/18722 0.150243970416979 0.413943941713481 STOM/PPIB 2 GO:0046415 urate metabolic process 2/998 13/18722 0.150243970416979 0.413943941713481 SLC22A11/PNP 2 GO:0046689 response to mercury ion 2/998 13/18722 0.150243970416979 0.413943941713481 BSG/ALAD 2 GO:0048266 behavioral response to pain 2/998 13/18722 0.150243970416979 0.413943941713481 VWA1/P2RX4 2 GO:0048820 hair follicle maturation 2/998 13/18722 0.150243970416979 0.413943941713481 FERMT1/CTNNB1 2 GO:0051956 negative regulation of amino acid transport 2/998 13/18722 0.150243970416979 0.413943941713481 SLC43A2/ARL6IP5 2 GO:0060100 positive regulation of phagocytosis, engulfment 2/998 13/18722 0.150243970416979 0.413943941713481 ANO6/RAB31 2 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/998 13/18722 0.150243970416979 0.413943941713481 AGO2/TNRC6A 2 GO:0060707 trophoblast giant cell differentiation 2/998 13/18722 0.150243970416979 0.413943941713481 NR2F2/HECTD1 2 GO:0070914 UV-damage excision repair 2/998 13/18722 0.150243970416979 0.413943941713481 DDB1/XPC 2 GO:0072393 microtubule anchoring at microtubule organizing center 2/998 13/18722 0.150243970416979 0.413943941713481 PCM1/GSK3B 2 GO:0072710 response to hydroxyurea 2/998 13/18722 0.150243970416979 0.413943941713481 ATRX/FMR1 2 GO:0090158 endoplasmic reticulum membrane organization 2/998 13/18722 0.150243970416979 0.413943941713481 LPCAT3/RTN4 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/998 13/18722 0.150243970416979 0.413943941713481 PTPN1/ATF6 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/998 13/18722 0.150243970416979 0.413943941713481 APP/PPP1R9A 2 GO:1900452 regulation of long-term synaptic depression 2/998 13/18722 0.150243970416979 0.413943941713481 PPP1R9A/FMR1 2 GO:1901096 regulation of autophagosome maturation 2/998 13/18722 0.150243970416979 0.413943941713481 CLN3/UVRAG 2 GO:1903651 positive regulation of cytoplasmic transport 2/998 13/18722 0.150243970416979 0.413943941713481 EZR/RDX 2 GO:1903977 positive regulation of glial cell migration 2/998 13/18722 0.150243970416979 0.413943941713481 LRP1/P2RX4 2 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 2/998 13/18722 0.150243970416979 0.413943941713481 DNMT1/PDCD4 2 GO:1905155 positive regulation of membrane invagination 2/998 13/18722 0.150243970416979 0.413943941713481 ANO6/RAB31 2 GO:1990403 embryonic brain development 2/998 13/18722 0.150243970416979 0.413943941713481 TRA2B/CTNNB1 2 GO:0034101 erythrocyte homeostasis 10/998 129/18722 0.150717836379618 0.414695841108872 CDK6/TGFBR3/PRKDC/RCOR1/UFL1/MAPK14/GATA3/RBFOX2/HSPA1B/HSPA9 10 GO:0071320 cellular response to cAMP 5/998 53/18722 0.150834591508475 0.414695841108872 APP/AKAP9/HSPA5/EZR/ASS1 5 GO:1903202 negative regulation of oxidative stress-induced cell death 5/998 53/18722 0.150834591508475 0.414695841108872 MET/CTNNB1/OXR1/NFE2L2/PAGE4 5 GO:1990090 cellular response to nerve growth factor stimulus 5/998 53/18722 0.150834591508475 0.414695841108872 APP/HSPA5/BPTF/KIDINS220/DYNC1LI2 5 GO:0043524 negative regulation of neuron apoptotic process 11/998 145/18722 0.151559929242842 0.416284173577371 NRP1/RASA1/LRP1/HSPD1/ERBB3/ISL1/CLN3/PRKCI/KRAS/BCL2/OXR1 11 GO:0070301 cellular response to hydrogen peroxide 8/998 98/18722 0.151651503187926 0.416284173577371 MET/NET1/MDM2/STK26/PAWR/PLEKHA1/HDAC2/NFE2L2 8 GO:1904029 regulation of cyclin-dependent protein kinase activity 8/998 98/18722 0.151651503187926 0.416284173577371 EGFR/NR2F2/CCND1/LATS2/CDKN1C/IPO7/CDK7/HEXIM1 8 GO:0007618 mating 4/998 39/18722 0.152364147659257 0.41736265211384 APP/SLC6A4/HEXB/HDAC2 4 GO:0046621 negative regulation of organ growth 4/998 39/18722 0.152364147659257 0.41736265211384 SLC6A4/GJA1/VGLL4/YY1 4 GO:0071548 response to dexamethasone 4/998 39/18722 0.152364147659257 0.41736265211384 EGFR/SERPINF1/ERRFI1/ASS1 4 GO:2000249 regulation of actin cytoskeleton reorganization 4/998 39/18722 0.152364147659257 0.41736265211384 NRP1/IQGAP2/CD2AP/TJP1 4 GO:0046785 microtubule polymerization 7/998 83/18722 0.153467337168931 0.419721822132971 MET/CLIP1/AKAP9/CAMSAP2/GOLGA2/OCLN/HSPA1B 7 GO:0051899 membrane depolarization 7/998 83/18722 0.153467337168931 0.419721822132971 IFI6/GJA5/ANK3/PARP1/P2RX4/BCL2/GPD1L 7 GO:0007585 respiratory gaseous exchange by respiratory system 6/998 68/18722 0.153627351483644 0.419721822132971 SLC5A3/FUT8/MAN1A2/GAA/ADH5/MAN2A1 6 GO:0042987 amyloid precursor protein catabolic process 6/998 68/18722 0.153627351483644 0.419721822132971 EFNA1/CLN3/DHCR24/NCSTN/RTN4/FLOT2 6 GO:0051148 negative regulation of muscle cell differentiation 6/998 68/18722 0.153627351483644 0.419721822132971 DNMT1/FOXO4/ANKRD17/BHLHE41/PDCD4/YY1 6 GO:0051047 positive regulation of secretion 21/998 310/18722 0.155171278914336 0.423718225529158 EGFR/MYH10/WLS/SLC6A4/GJA1/LRP1/EXPH5/FRMD4A/SCIN/KCNN4/ISL1/SYT7/EXOC1/CD2AP/EZR/PLA2R1/P2RX4/TCF7L2/ACSL3/SNX4/TMF1 21 GO:0018212 peptidyl-tyrosine modification 25/998 378/18722 0.156856597398028 0.428096338220127 EGFR/APP/MET/EFEMP1/NRP1/IGF1R/CD24/PRLR/EPHB4/IL6ST/TPST2/ERBB3/ISL1/EFNA1/YES1/SUZ12/WEE1/PTPN1/ERRFI1/FGFR2/BAZ1B/DDR1/NEDD9/PTK2/HDAC2 25 GO:0010948 negative regulation of cell cycle process 20/998 294/18722 0.157774068849038 0.430054045958751 BMP7/DLG1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/ATRX/TPR/CCND1/WEE1/BRD7/RAD21/EIF2AK4/MAPK14/WAPL/BCL2/PLK2/XPC/PPP1R10 20 GO:0060996 dendritic spine development 8/998 99/18722 0.157821021271206 0.430054045958751 DLG5/PPP1R9A/EFNA1/CDKL5/FMR1/DHX36/PLK2/HDAC2 8 GO:0110149 regulation of biomineralization 8/998 99/18722 0.157821021271206 0.430054045958751 FBN2/ATP2B1/BMP7/ANO6/TFAP2A/ANKH/LTBP3/ATRAID 8 GO:0006517 protein deglycosylation 3/998 26/18722 0.158832522877559 0.430786806204539 MAN1A2/EDEM3/MAN2A1 3 GO:0006760 folic acid-containing compound metabolic process 3/998 26/18722 0.158832522877559 0.430786806204539 SLC19A1/GGH/FOLR1 3 GO:0010875 positive regulation of cholesterol efflux 3/998 26/18722 0.158832522877559 0.430786806204539 LRP1/ABCA1/PPARG 3 GO:0018027 peptidyl-lysine dimethylation 3/998 26/18722 0.158832522877559 0.430786806204539 ASH1L/SMYD2/SETD2 3 GO:0034063 stress granule assembly 3/998 26/18722 0.158832522877559 0.430786806204539 DYNC1H1/PRRC2C/ATXN2 3 GO:0048668 collateral sprouting 3/998 26/18722 0.158832522877559 0.430786806204539 APP/LRP1/COBL 3 GO:0051560 mitochondrial calcium ion homeostasis 3/998 26/18722 0.158832522877559 0.430786806204539 TGM2/AFG3L2/BCAP31 3 GO:0099637 neurotransmitter receptor transport 3/998 26/18722 0.158832522877559 0.430786806204539 CLSTN1/VPS35/NSG1 3 GO:1905523 positive regulation of macrophage migration 3/998 26/18722 0.158832522877559 0.430786806204539 P2RX4/MMP14/PTK2 3 GO:0007215 glutamate receptor signaling pathway 5/998 54/18722 0.159440396402868 0.431538781554886 APP/CLN3/HOMER1/NCSTN/FMR1 5 GO:0014888 striated muscle adaptation 5/998 54/18722 0.159440396402868 0.431538781554886 ATP2B4/CAMK2G/ERRFI1/ATP2A2/LMNA 5 GO:0035065 regulation of histone acetylation 5/998 54/18722 0.159440396402868 0.431538781554886 ZNF451/ISL1/RPS6KA5/BRD7/GATA3 5 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 5/998 54/18722 0.159440396402868 0.431538781554886 TEAD1/KLF5/PPARG/GATA3/YY1 5 GO:0002088 lens development in camera-type eye 7/998 84/18722 0.160266618281783 0.432238400793417 DLG1/KDM5B/FAT1/TGFBR1/CRYBG3/CTNNB1/GATA3 7 GO:0032508 DNA duplex unwinding 7/998 84/18722 0.160266618281783 0.432238400793417 RAD50/ATRX/PURA/NAV2/DHX36/DDX1/CHD6 7 GO:0045445 myoblast differentiation 7/998 84/18722 0.160266618281783 0.432238400793417 MBNL3/ISL1/DDX17/MAPK14/TCF7L2/PLEC/FLOT2 7 GO:0000077 DNA damage checkpoint signaling 9/998 115/18722 0.160269140016209 0.432238400793417 FOXO4/PRKDC/MDM2/CCND1/EIF2AK4/MAPK14/PLK2/XPC/PPP1R10 9 GO:0043279 response to alkaloid 9/998 115/18722 0.160269140016209 0.432238400793417 HSPA5/TGM2/HSPD1/MDM2/DNMT3A/HOMER1/SLC1A3/HDAC2/UQCRC1 9 GO:0007626 locomotory behavior 13/998 179/18722 0.160278403358754 0.432238400793417 APP/DPP4/HEXB/MCOLN3/ANKH/ZFHX3/PUM1/VPS13A/NAV2/GAA/EPS8/ALDH1A3/OXR1 13 GO:1901991 negative regulation of mitotic cell cycle phase transition 13/998 179/18722 0.160278403358754 0.432238400793417 DLG1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/TPR/CCND1/WEE1/BRD7/RAD21/BCL2/PLK2 13 GO:0006612 protein targeting to membrane 10/998 131/18722 0.161414501380165 0.434628732184549 TCAF1/HSPA5/ANK3/SIL1/PRKCI/PARD3/TRAM2/SEC63/MYO1C/STOM 10 GO:0019827 stem cell population maintenance 10/998 131/18722 0.161414501380165 0.434628732184549 BMP7/NCOA3/LRP5/YAP1/ZC3H13/TP63/RIF1/PCM1/CTNNB1/NIPBL 10 GO:1904950 negative regulation of establishment of protein localization 10/998 131/18722 0.161414501380165 0.434628732184549 LMAN1/FRMD4A/FERMT1/ERLEC1/ERP29/NDFIP2/GOPC/RAB11FIP1/LYPLA1/UBE2G2 10 GO:0006874 cellular calcium ion homeostasis 29/998 448/18722 0.162195546312782 0.436506673865481 APP/ATP2B1/HSP90B1/ITGAV/GJA1/CD55/TGM2/CCDC47/LRP1/CD24/CALR/ATP13A3/GTF2I/ATP2B4/HEXB/MCOLN3/DMD/CLN3/TRPV6/AFG3L2/P2RX4/SWAP70/BCAP31/TMEM165/GPR157/BCL2/ATP2A2/STC2/SPPL3 29 GO:1901998 toxin transport 4/998 40/18722 0.162634821383453 0.437238106304329 NRP1/HSPA5/ANTXR2/COPB2 4 GO:2000781 positive regulation of double-strand break repair 4/998 40/18722 0.162634821383453 0.437238106304329 PARP1/FUS/PRKDC/RIF1 4 GO:0006664 glycolipid metabolic process 8/998 100/18722 0.164107032797326 0.44074219045002 ITGB8/PGAP1/HEXB/FUCA1/HEXA/GM2A/SUMF1/GLB1 8 GO:0045807 positive regulation of endocytosis 8/998 100/18722 0.164107032797326 0.44074219045002 ANO6/LRP1/CLN3/AHI1/FMR1/RAB31/GPC3/ANXA2 8 GO:0008286 insulin receptor signaling pathway 9/998 116/18722 0.166123261216035 0.444413942614902 KANK1/IGF1R/FOXO4/GAB1/SORBS1/PTPN1/SMARCC1/PTPRA/GSK3B 9 GO:0043200 response to amino acid 9/998 116/18722 0.166123261216035 0.444413942614902 SLC38A9/DNMT1/DNMT3A/UFL1/CDO1/ASS1/COL5A2/ALAD/TOMM20 9 GO:0044774 mitotic DNA integrity checkpoint signaling 7/998 85/18722 0.167199587291246 0.444413942614902 FOXO4/PRKDC/MDM2/CCND1/PLK2/XPC/PPP1R10 7 GO:0072384 organelle transport along microtubule 7/998 85/18722 0.167199587291246 0.444413942614902 DYNC1H1/ARHGAP21/CLN3/LRPPRC/RAB6A/SUN1/ARMCX3 7 GO:0097006 regulation of plasma lipoprotein particle levels 7/998 85/18722 0.167199587291246 0.444413942614902 LRPAP1/ABCA1/LPCAT3/CNPY2/MYLIP/ACSL3/ANXA2 7 GO:0010952 positive regulation of peptidase activity 14/998 197/18722 0.167858673966282 0.444413942614902 APP/FBLN1/ASPH/PERP/CLDN4/ARL6IP5/PCOLCE2/HSPD1/EFNA1/NCSTN/PPARG/BCAP31/VCP/PMAIP1 14 GO:0002067 glandular epithelial cell differentiation 5/998 55/18722 0.168240279069949 0.444413942614902 CDK6/TP63/FGFR2/GSK3B/FASN 5 GO:0038066 p38MAPK cascade 5/998 55/18722 0.168240279069949 0.444413942614902 DLG1/MAP3K4/EZR/MAPK14/EMC10 5 GO:0043331 response to dsRNA 5/998 55/18722 0.168240279069949 0.444413942614902 COLEC12/TLR3/DHX36/DDX1/PMAIP1 5 GO:0044091 membrane biogenesis 5/998 55/18722 0.168240279069949 0.444413942614902 ANK3/REEP3/SPTBN1/FLOT2/ANXA2 5 GO:0048016 inositol phosphate-mediated signaling 5/998 55/18722 0.168240279069949 0.444413942614902 NFAT5/ATP2B4/SLC9A1/SPPL3/GSK3B 5 GO:0061098 positive regulation of protein tyrosine kinase activity 5/998 55/18722 0.168240279069949 0.444413942614902 CD24/ERBB3/EFNA1/PTPN1/NEDD9 5 GO:0061614 pri-miRNA transcription by RNA polymerase II 5/998 55/18722 0.168240279069949 0.444413942614902 TEAD1/KLF5/PPARG/GATA3/YY1 5 GO:0003407 neural retina development 6/998 70/18722 0.168954628915609 0.444413942614902 ATP2B1/ATP2B4/TFAP2A/OBSL1/AHI1/PTPRM 6 GO:0046394 carboxylic acid biosynthetic process 21/998 314/18722 0.169039851842804 0.444413942614902 ACSS1/DEGS1/SLC27A2/HACD3/MGST3/ATP2B4/MTR/ACADVL/CLN3/OSBPL9/SLC1A3/AASDHPPT/ALDH18A1/ALDH1A3/ASS1/ACSL3/SERINC3/FASN/QKI/BCAT1/TECR 21 GO:0000212 meiotic spindle organization 2/998 14/18722 0.169389723387024 0.444413942614902 ATRX/GOLGA2 2 GO:0001767 establishment of lymphocyte polarity 2/998 14/18722 0.169389723387024 0.444413942614902 DOCK8/FLOT2 2 GO:0001771 immunological synapse formation 2/998 14/18722 0.169389723387024 0.444413942614902 DLG1/DOCK8 2 GO:0001921 positive regulation of receptor recycling 2/998 14/18722 0.169389723387024 0.444413942614902 NSG1/ANXA2 2 GO:0002091 negative regulation of receptor internalization 2/998 14/18722 0.169389723387024 0.444413942614902 LRPAP1/ATXN2 2 GO:0003188 heart valve formation 2/998 14/18722 0.169389723387024 0.444413942614902 GJA5/EFNA1 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/998 14/18722 0.169389723387024 0.444413942614902 TRIP11/SERPINH1 2 GO:0006521 regulation of cellular amino acid metabolic process 2/998 14/18722 0.169389723387024 0.444413942614902 ATP2B4/CLN3 2 GO:0006596 polyamine biosynthetic process 2/998 14/18722 0.169389723387024 0.444413942614902 SMS/AZIN1 2 GO:0006999 nuclear pore organization 2/998 14/18722 0.169389723387024 0.444413942614902 TPR/RTN4 2 GO:0009071 serine family amino acid catabolic process 2/998 14/18722 0.169389723387024 0.444413942614902 GLDC/CDO1 2 GO:0010421 hydrogen peroxide-mediated programmed cell death 2/998 14/18722 0.169389723387024 0.444413942614902 MET/PAWR 2 GO:0019321 pentose metabolic process 2/998 14/18722 0.169389723387024 0.444413942614902 UXS1/RPIA 2 GO:0035672 oligopeptide transmembrane transport 2/998 14/18722 0.169389723387024 0.444413942614902 GJA1/SLC13A3 2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/998 14/18722 0.169389723387024 0.444413942614902 LRP1/PTPN1 2 GO:0042921 glucocorticoid receptor signaling pathway 2/998 14/18722 0.169389723387024 0.444413942614902 CALR/NEDD4 2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 2/998 14/18722 0.169389723387024 0.444413942614902 PLA2R1/PMAIP1 2 GO:0043558 regulation of translational initiation in response to stress 2/998 14/18722 0.169389723387024 0.444413942614902 EIF2AK1/EIF2AK4 2 GO:0045837 negative regulation of membrane potential 2/998 14/18722 0.169389723387024 0.444413942614902 ARL6IP5/PMAIP1 2 GO:0046655 folic acid metabolic process 2/998 14/18722 0.169389723387024 0.444413942614902 SLC19A1/FOLR1 2 GO:0047484 regulation of response to osmotic stress 2/998 14/18722 0.169389723387024 0.444413942614902 CLN3/ABCB1 2 GO:0051589 negative regulation of neurotransmitter transport 2/998 14/18722 0.169389723387024 0.444413942614902 PPP1R9A/FMR1 2 GO:0051645 Golgi localization 2/998 14/18722 0.169389723387024 0.444413942614902 ARHGAP21/UVRAG 2 GO:0060088 auditory receptor cell stereocilium organization 2/998 14/18722 0.169389723387024 0.444413942614902 MYO7A/TRIOBP 2 GO:0071285 cellular response to lithium ion 2/998 14/18722 0.169389723387024 0.444413942614902 CDH1/CALR 2 GO:0071481 cellular response to X-ray 2/998 14/18722 0.169389723387024 0.444413942614902 GATA3/NIPBL 2 GO:0072498 embryonic skeletal joint development 2/998 14/18722 0.169389723387024 0.444413942614902 BMP7/CTNNB1 2 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 2/998 14/18722 0.169389723387024 0.444413942614902 DNMT1/MPHOSPH8 2 GO:0099188 postsynaptic cytoskeleton organization 2/998 14/18722 0.169389723387024 0.444413942614902 PPP1R9A/WASF2 2 GO:0099638 endosome to plasma membrane protein transport 2/998 14/18722 0.169389723387024 0.444413942614902 VPS35/NSG1 2 GO:1901722 regulation of cell proliferation involved in kidney development 2/998 14/18722 0.169389723387024 0.444413942614902 BMP7/GATA3 2 GO:0044242 cellular lipid catabolic process 15/998 214/18722 0.170201245787516 0.446318786668318 SLC27A2/LRP1/IDH1/HADHA/HEXB/FUCA1/CROT/ECHDC2/ACADVL/ECI2/CPT2/HEXA/GM2A/ECHDC1/ETFA 15 GO:1903509 liposaccharide metabolic process 8/998 101/18722 0.170506848671748 0.446895711302811 ITGB8/PGAP1/HEXB/FUCA1/HEXA/GM2A/SUMF1/GLB1 8 GO:0032368 regulation of lipid transport 11/998 149/18722 0.172046414862909 0.447639736366271 ITGAV/LRP1/ABCA1/LPCAT3/KDM5B/PLA2R1/P2RX4/PPARG/TMEM30A/TMF1/ANXA2 11 GO:0051592 response to calcium ion 11/998 149/18722 0.172046414862909 0.447639736366271 EGFR/HSPA5/FUS/SYT7/SEC31A/CCND1/HOMER1/NCSTN/TRPV6/NEDD4/AHCYL1 11 GO:0003171 atrioventricular valve development 3/998 27/18722 0.172055212768978 0.447639736366271 GJA5/MDM2/EFNA1 3 GO:0008053 mitochondrial fusion 3/998 27/18722 0.172055212768978 0.447639736366271 TFRC/HUWE1/AFG3L2 3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/998 27/18722 0.172055212768978 0.447639736366271 DMD/SLC9A1/ATP2A2 3 GO:0015813 L-glutamate transmembrane transport 3/998 27/18722 0.172055212768978 0.447639736366271 ITGB1/ARL6IP5/SLC1A3 3 GO:0034377 plasma lipoprotein particle assembly 3/998 27/18722 0.172055212768978 0.447639736366271 ABCA1/LPCAT3/ACSL3 3 GO:0035116 embryonic hindlimb morphogenesis 3/998 27/18722 0.172055212768978 0.447639736366271 TP63/CTNNB1/GPC3 3 GO:0042403 thyroid hormone metabolic process 3/998 27/18722 0.172055212768978 0.447639736366271 SLC16A2/GCNT4/GATA3 3 GO:0060512 prostate gland morphogenesis 3/998 27/18722 0.172055212768978 0.447639736366271 BMP7/TP63/FGFR2 3 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 3/998 27/18722 0.172055212768978 0.447639736366271 SEMA6A/PIK3CB/MYO1C 3 GO:1902883 negative regulation of response to oxidative stress 3/998 27/18722 0.172055212768978 0.447639736366271 MET/OXR1/NFE2L2 3 GO:1902914 regulation of protein polyubiquitination 3/998 27/18722 0.172055212768978 0.447639736366271 SKP2/TRIM44/UBR5 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/998 27/18722 0.172055212768978 0.447639736366271 PARP1/CTNNB1/OXR1 3 GO:0014902 myotube differentiation 9/998 117/18722 0.172076795802932 0.447639736366271 ERVW-1/MYOF/KLF5/HOMER1/MAPK14/BHLHE41/MMP14/BCL2/PLEC 9 GO:0048167 regulation of synaptic plasticity 14/998 198/18722 0.172385336924692 0.448219045858475 APP/MME/PPP1R9A/SYT7/CLN3/ERC1/NCSTN/FMR1/KRAS/EIF2AK4/PLK2/GSK3B/SHANK2/NSG1 14 GO:0001953 negative regulation of cell-matrix adhesion 4/998 41/18722 0.173147480010406 0.449305662591615 RASA1/LRP1/MMP14/PHLDB2 4 GO:0032735 positive regulation of interleukin-12 production 4/998 41/18722 0.173147480010406 0.449305662591615 HSPD1/ISL1/TLR3/MAPK14 4 GO:0050892 intestinal absorption 4/998 41/18722 0.173147480010406 0.449305662591615 LIMA1/LPCAT3/EZR/ACO1 4 GO:0055023 positive regulation of cardiac muscle tissue growth 4/998 41/18722 0.173147480010406 0.449305662591615 TGFBR3/YAP1/MAPK14/FGFR2 4 GO:0009798 axis specification 7/998 86/18722 0.174262459736344 0.451974318074243 WLS/PGAP1/COBL/AHI1/CTNNB1/FZD5/GPC3 7 GO:0051607 defense response to virus 18/998 265/18722 0.174554680898623 0.452282872938813 IFI6/IL10RB/NCBP3/SKP2/EXOC1/TRIM44/DDX17/TLR3/PUM1/ANKRD17/SETD2/HSP90AA1/EIF2AK4/DHX36/DDX1/BCL2/SERINC3/PMAIP1 18 GO:0140546 defense response to symbiont 18/998 265/18722 0.174554680898623 0.452282872938813 IFI6/IL10RB/NCBP3/SKP2/EXOC1/TRIM44/DDX17/TLR3/PUM1/ANKRD17/SETD2/HSP90AA1/EIF2AK4/DHX36/DDX1/BCL2/SERINC3/PMAIP1 18 GO:0060538 skeletal muscle organ development 12/998 166/18722 0.176061157797873 0.455959972650146 DAG1/NR2F2/DMD/DDX17/KLF5/HOMER1/MAPK14/CTNNB1/BCL2/ASS1/PLEC/GPC1 12 GO:0000281 mitotic cytokinesis 6/998 71/18722 0.176849224288311 0.456935525425171 MYH10/RASA1/ANK3/SON/SPTBN1/TTC19 6 GO:0050795 regulation of behavior 6/998 71/18722 0.176849224288311 0.456935525425171 ADRB1/GJA1/ZFHX3/AHI1/EIF2AK4/HDAC2 6 GO:0006672 ceramide metabolic process 8/998 102/18722 0.177017657517101 0.456935525425171 DEGS1/ORMDL1/ITGB8/PLPP3/HEXB/SPTLC3/HEXA/GM2A 8 GO:0002090 regulation of receptor internalization 5/998 56/18722 0.177225519821101 0.456935525425171 LRPAP1/AHI1/FMR1/ATXN2/OPHN1 5 GO:0042733 embryonic digit morphogenesis 5/998 56/18722 0.177225519821101 0.456935525425171 LRP5/GLI3/FZD6/CTNNB1/HDAC2 5 GO:0043388 positive regulation of DNA binding 5/998 56/18722 0.177225519821101 0.456935525425171 PARP1/ISL1/PPARG/CTNNB1/GATA3 5 GO:0048008 platelet-derived growth factor receptor signaling pathway 5/998 56/18722 0.177225519821101 0.456935525425171 NRP1/LRP1/PTPN1/ARID5B/PLEKHA1 5 GO:0051653 spindle localization 5/998 56/18722 0.177225519821101 0.456935525425171 ITGB1/GJA1/DYNC1H1/MAP4/GPSM2 5 GO:1990089 response to nerve growth factor 5/998 56/18722 0.177225519821101 0.456935525425171 APP/HSPA5/BPTF/KIDINS220/DYNC1LI2 5 GO:1901988 negative regulation of cell cycle phase transition 17/998 249/18722 0.177567396634734 0.457591005839065 DLG1/FOXO4/PRKDC/CTDSPL/MDM2/USP47/TPR/CCND1/WEE1/BRD7/RAD21/EIF2AK4/MAPK14/BCL2/PLK2/XPC/PPP1R10 17 GO:0006413 translational initiation 9/998 118/18722 0.17812758289927 0.458590964893399 EIF3A/EIF2AK1/TPR/EIF4G1/FMR1/EIF2AK4/DDX1/AGO2/DENR 9 GO:0098727 maintenance of cell number 10/998 134/18722 0.178131100709407 0.458590964893399 BMP7/NCOA3/LRP5/YAP1/ZC3H13/TP63/RIF1/PCM1/CTNNB1/NIPBL 10 GO:0051146 striated muscle cell differentiation 19/998 283/18722 0.179200316529014 0.461116240807286 ITGB1/ERVW-1/CALR/MYOF/ISL1/OBSL1/SPAG9/SLC9A1/KLF5/HOMER1/KRAS/MAPK14/BHLHE41/MMP14/BCL2/PLEC/YY1/LMNA/HNRNPU 19 GO:0055067 monovalent inorganic cation homeostasis 11/998 151/18722 0.182766051240489 0.470059878584528 SLC12A9/ATP6V1B1/CLN3/SLC9A1/SLC1A3/TMEM106B/TM9SF4/TMEM165/BCL2/EXT2/TTPA 11 GO:0030004 cellular monovalent inorganic cation homeostasis 8/998 103/18722 0.18363653202343 0.470854195179873 CLN3/SLC9A1/SLC1A3/TMEM106B/TM9SF4/TMEM165/BCL2/TTPA 8 GO:0000413 protein peptidyl-prolyl isomerization 4/998 42/18722 0.183886555060671 0.470854195179873 NKTR/FKBP14/RANBP2/PPIB 4 GO:0030574 collagen catabolic process 4/998 42/18722 0.183886555060671 0.470854195179873 CTSL/ITGB1/MMP15/MMP14 4 GO:0030890 positive regulation of B cell proliferation 4/998 42/18722 0.183886555060671 0.470854195179873 TFRC/SLC39A10/VAV3/BCL2 4 GO:0035019 somatic stem cell population maintenance 4/998 42/18722 0.183886555060671 0.470854195179873 BMP7/LRP5/YAP1/TP63 4 GO:0051452 intracellular pH reduction 4/998 42/18722 0.183886555060671 0.470854195179873 CLN3/TMEM106B/BCL2/TTPA 4 GO:0090317 negative regulation of intracellular protein transport 4/998 42/18722 0.183886555060671 0.470854195179873 LMAN1/FERMT1/ERLEC1/UBE2G2 4 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/998 42/18722 0.183886555060671 0.470854195179873 TEAD1/KLF5/PPARG/GATA3 4 GO:2001222 regulation of neuron migration 4/998 42/18722 0.183886555060671 0.470854195179873 ADGRG1/SEMA6A/ZNF609/NIPBL 4 GO:0051057 positive regulation of small GTPase mediated signal transduction 6/998 72/18722 0.1848901911694 0.472860210270528 ADGRG1/ITGAV/TGM2/NET1/PIK3CB/KRAS 6 GO:0000303 response to superoxide 3/998 28/18722 0.185575669573705 0.472860210270528 BMP7/SOD3/NFE2L2 3 GO:0006972 hyperosmotic response 3/998 28/18722 0.185575669573705 0.472860210270528 SLC2A1/TLR3/ERRFI1 3 GO:0015740 C4-dicarboxylate transport 3/998 28/18722 0.185575669573705 0.472860210270528 SLC13A3/SLC1A5/SLC1A3 3 GO:0031440 regulation of mRNA 3'-end processing 3/998 28/18722 0.185575669573705 0.472860210270528 AHCYL1/DHX36/ZC3H14 3 GO:0042983 amyloid precursor protein biosynthetic process 3/998 28/18722 0.185575669573705 0.472860210270528 PAWR/NCSTN/AGO2 3 GO:0042984 regulation of amyloid precursor protein biosynthetic process 3/998 28/18722 0.185575669573705 0.472860210270528 PAWR/NCSTN/AGO2 3 GO:0045671 negative regulation of osteoclast differentiation 3/998 28/18722 0.185575669573705 0.472860210270528 FBN1/TLR3/CTNNB1 3 GO:0090344 negative regulation of cell aging 3/998 28/18722 0.185575669573705 0.472860210270528 CDK6/PRKDC/PLK2 3 GO:1903671 negative regulation of sprouting angiogenesis 3/998 28/18722 0.185575669573705 0.472860210270528 SEMA6A/EPN2/PIK3CB 3 GO:0010883 regulation of lipid storage 5/998 57/18722 0.186387163933933 0.473500618058786 ITGAV/MEST/ABCA1/PPARG/HILPDA 5 GO:1902017 regulation of cilium assembly 5/998 57/18722 0.186387163933933 0.473500618058786 YAP1/ATMIN/CDKL5/LIMK2/MAP4 5 GO:0051348 negative regulation of transferase activity 18/998 268/18722 0.18660515985541 0.473500618058786 BMP7/NR2F2/NF1/LRP5/PKIB/LATS2/PTPN1/PPARG/PIK3CB/ERRFI1/MLLT1/CDKN1C/IPO7/PLEC/PDCD4/GSK3B/HEXIM1/HNRNPU 18 GO:0050804 modulation of chemical synaptic transmission 28/998 439/18722 0.187067459529723 0.473500618058786 EGFR/APP/CDH1/MME/SLC6A4/AKAP9/ITGB1/PPP1R9A/SYT7/CLN3/ERC1/HOMER1/S1PR2/NCSTN/FMR1/SLC1A3/CLSTN1/KRAS/EIF2AK4/GNAI1/PLK2/ATP2A2/PTPRA/GSK3B/OPHN1/MCTP2/SHANK2/NSG1 28 GO:0030509 BMP signaling pathway 11/998 152/18722 0.188240022419686 0.473500618058786 FBN1/LRP2/CRIM1/BMP7/TGFBR3/TRIM33/FSTL1/USP9X/PPARG/PDCD4/GPC3 11 GO:0010763 positive regulation of fibroblast migration 2/998 15/18722 0.188910512816788 0.473500618058786 ITGB1/PTK2 2 GO:0014733 regulation of skeletal muscle adaptation 2/998 15/18722 0.188910512816788 0.473500618058786 CAMK2G/ATP2A2 2 GO:0015697 quaternary ammonium group transport 2/998 15/18722 0.188910512816788 0.473500618058786 SLC22A5/SLC38A2 2 GO:0031958 corticosteroid receptor signaling pathway 2/998 15/18722 0.188910512816788 0.473500618058786 CALR/NEDD4 2 GO:0032239 regulation of nucleobase-containing compound transport 2/998 15/18722 0.188910512816788 0.473500618058786 TPR/SETD2 2 GO:0032486 Rap protein signal transduction 2/998 15/18722 0.188910512816788 0.473500618058786 RDX/PLK2 2 GO:0032488 Cdc42 protein signal transduction 2/998 15/18722 0.188910512816788 0.473500618058786 NRP1/ABCA1 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/998 15/18722 0.188910512816788 0.473500618058786 ISL1/TP63 2 GO:0035435 phosphate ion transmembrane transport 2/998 15/18722 0.188910512816788 0.473500618058786 ANKH/SLC20A2 2 GO:0036124 histone H3-K9 trimethylation 2/998 15/18722 0.188910512816788 0.473500618058786 ATRX/LMNA 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/998 15/18722 0.188910512816788 0.473500618058786 PTTG1IP/MDM2 2 GO:0043584 nose development 2/998 15/18722 0.188910512816788 0.473500618058786 GLI3/ALDH1A3 2 GO:0060099 regulation of phagocytosis, engulfment 2/998 15/18722 0.188910512816788 0.473500618058786 ANO6/RAB31 2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/998 15/18722 0.188910512816788 0.473500618058786 AGO2/TNRC6A 2 GO:0060456 positive regulation of digestive system process 2/998 15/18722 0.188910512816788 0.473500618058786 LPCAT3/SLC22A5 2 GO:0070071 proton-transporting two-sector ATPase complex assembly 2/998 15/18722 0.188910512816788 0.473500618058786 ATP6V1B1/TM9SF4 2 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 2/998 15/18722 0.188910512816788 0.473500618058786 ATP2B4/GSK3B 2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 2/998 15/18722 0.188910512816788 0.473500618058786 SLC9A1/SPPL3 2 GO:0071474 cellular hyperosmotic response 2/998 15/18722 0.188910512816788 0.473500618058786 SLC2A1/ERRFI1 2 GO:0071871 response to epinephrine 2/998 15/18722 0.188910512816788 0.473500618058786 ATP2B4/SLC9A1 2 GO:0090110 COPII-coated vesicle cargo loading 2/998 15/18722 0.188910512816788 0.473500618058786 SEC31A/MIA3 2 GO:0097468 programmed cell death in response to reactive oxygen species 2/998 15/18722 0.188910512816788 0.473500618058786 MET/PAWR 2 GO:0106057 negative regulation of calcineurin-mediated signaling 2/998 15/18722 0.188910512816788 0.473500618058786 ATP2B4/GSK3B 2 GO:0106058 positive regulation of calcineurin-mediated signaling 2/998 15/18722 0.188910512816788 0.473500618058786 SLC9A1/SPPL3 2 GO:1900029 positive regulation of ruffle assembly 2/998 15/18722 0.188910512816788 0.473500618058786 COBL/EPS8 2 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/998 15/18722 0.188910512816788 0.473500618058786 DHX36/AGO2 2 GO:1901660 calcium ion export 2/998 15/18722 0.188910512816788 0.473500618058786 ATP2B1/ATP2B4 2 GO:1905168 positive regulation of double-strand break repair via homologous recombination 2/998 15/18722 0.188910512816788 0.473500618058786 PARP1/FUS 2 GO:2001028 positive regulation of endothelial cell chemotaxis 2/998 15/18722 0.188910512816788 0.473500618058786 MET/P2RX4 2 GO:0007159 leukocyte cell-cell adhesion 24/998 371/18722 0.18991875587189 0.47579933992665 CD46/BMP7/DPP4/TFRC/NFAT5/DLG5/ITGB1/DLG1/CD55/OLR1/CD24/CD47/IL6ST/HSPD1/GLI3/DOCK8/PAWR/YES1/EZR/MIA3/GATA3/ASS1/FLOT2/PNP 24 GO:0099177 regulation of trans-synaptic signaling 28/998 440/18722 0.190262483666782 0.476370784114032 EGFR/APP/CDH1/MME/SLC6A4/AKAP9/ITGB1/PPP1R9A/SYT7/CLN3/ERC1/HOMER1/S1PR2/NCSTN/FMR1/SLC1A3/CLSTN1/KRAS/EIF2AK4/GNAI1/PLK2/ATP2A2/PTPRA/GSK3B/OPHN1/MCTP2/SHANK2/NSG1 28 GO:0048661 positive regulation of smooth muscle cell proliferation 8/998 104/18722 0.190360435407978 0.476370784114032 EGFR/GJA1/ADAMTS1/TGM2/DNMT1/SKP2/MDM2/FGFR2 8 GO:0006304 DNA modification 9/998 120/18722 0.190511817128921 0.476370784114032 DNMT1/PARP1/DNMT3A/ATRX/TET2/USP9X/MPHOSPH8/GATA3/OTUD4 9 GO:0072655 establishment of protein localization to mitochondrion 9/998 120/18722 0.190511817128921 0.476370784114032 LMAN1/HSPD1/HUWE1/LEPROT/NPEPPS/HSP90AA1/BCAP31/FZD5/TOMM20 9 GO:0006937 regulation of muscle contraction 12/998 169/18722 0.191554438351143 0.478748550804843 DSP/ATP2B1/DSC2/AKAP9/DLG1/GJA5/DSG2/DMD/SLC9A1/P2RX4/PKP2/ATP2A2 12 GO:0032456 endocytic recycling 6/998 73/18722 0.193071610327825 0.481618192795784 KIAA1109/CMTM6/RAB11FIP4/SNX4/VPS35/NSG1 6 GO:0050848 regulation of calcium-mediated signaling 6/998 73/18722 0.193071610327825 0.481618192795784 NFAT5/ATP2B4/SLC9A1/P2RX4/SPPL3/GSK3B 6 GO:0051145 smooth muscle cell differentiation 6/998 73/18722 0.193071610327825 0.481618192795784 DNMT1/FOXO4/ANKRD17/FGFR2/CTNNB1/PDCD4 6 GO:0070988 demethylation 6/998 73/18722 0.193071610327825 0.481618192795784 KDM5B/TET2/USP9X/GATA3/KDM4B/OTUD4 6 GO:0008217 regulation of blood pressure 13/998 186/18722 0.194054730297439 0.483608471065836 MME/ATP2B1/ADRB1/ENPEP/GJA1/NR2F2/LRP5/GJA5/P2RX4/PPARG/NAV2/ADH5/EXT2 13 GO:1902115 regulation of organelle assembly 13/998 186/18722 0.194054730297439 0.483608471065836 YAP1/DYNC1H1/ATMIN/TPR/CDKL5/LIMK2/EZR/RDX/PLK2/MAP4/HSPA1B/GPSM2/HNRNPU 13 GO:0009268 response to pH 4/998 43/18722 0.194836307732165 0.48463094934237 SERPINF1/GJA1/SLC9A1/TTPA 4 GO:0034661 ncRNA catabolic process 4/998 43/18722 0.194836307732165 0.48463094934237 KCNQ1OT1/LIN28B/SND1/DICER1 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/998 43/18722 0.194836307732165 0.48463094934237 GNA12/S1PR2/PPARG/PDCD4 4 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/998 43/18722 0.194836307732165 0.48463094934237 IFI6/BCL2/HSPA1B/CTNNA1 4 GO:0000086 G2/M transition of mitotic cell cycle 10/998 137/18722 0.195612352021572 0.484970827376303 APP/BRD4/PBX1/FOXO4/SKP2/USP47/CCND1/WEE1/RAD21/ABCB1 10 GO:0045471 response to ethanol 10/998 137/18722 0.195612352021572 0.484970827376303 GGH/DNMT3A/CCND1/CDO1/FGFR2/EPS8/GATA3/SDF4/ALAD/HDAC2 10 GO:0002931 response to ischemia 5/998 58/18722 0.195716056939642 0.484970827376303 GJA1/HSPD1/P2RX4/PIK3CB/BCL2 5 GO:0007405 neuroblast proliferation 5/998 58/18722 0.195716056939642 0.484970827376303 NF1/GLI3/FGFR2/CTNNB1/CTNNA1 5 GO:0010043 response to zinc ion 5/998 58/18722 0.195716056939642 0.484970827376303 PARP1/GGH/P2RX4/ASS1/ALAD 5 GO:0032387 negative regulation of intracellular transport 5/998 58/18722 0.195716056939642 0.484970827376303 LMAN1/FERMT1/ERLEC1/TPR/UBE2G2 5 GO:0032481 positive regulation of type I interferon production 5/998 58/18722 0.195716056939642 0.484970827376303 HSPD1/TLR3/SETD2/HSP90AA1/DHX36 5 GO:0043666 regulation of phosphoprotein phosphatase activity 5/998 58/18722 0.195716056939642 0.484970827376303 HSP90B1/SLC39A10/BOD1L1/GSK3B/PPP6R2 5 GO:0000041 transition metal ion transport 8/998 105/18722 0.197186227963089 0.488382019067973 TFRC/SLC39A10/SLC40A1/CLTC/SLC39A7/SLC39A1/TMEM165/SLC30A7 8 GO:0019318 hexose metabolic process 16/998 237/18722 0.198179450457671 0.489588273335724 DDB1/LRP5/SLC35B4/FUT8/FUCA1/B4GALT1/SORBS1/MAPK14/FAM3C/GAA/RANBP2/MAN2A1/GSK3B/PMAIP1/PHLDA2/GLB1 16 GO:0006839 mitochondrial transport 17/998 254/18722 0.198761058179824 0.489588273335724 LMAN1/HSPD1/SLC25A36/HUWE1/SLC9A1/LEPROT/AFG3L2/NPEPPS/HSP90AA1/BCAP31/CPT2/FZD5/BCL2/GSK3B/PMAIP1/VPS35/TOMM20 17 GO:0000305 response to oxygen radical 3/998 29/18722 0.199361170103763 0.489588273335724 BMP7/SOD3/NFE2L2 3 GO:0002068 glandular epithelial cell development 3/998 29/18722 0.199361170103763 0.489588273335724 CDK6/GSK3B/FASN 3 GO:0002360 T cell lineage commitment 3/998 29/18722 0.199361170103763 0.489588273335724 CTSL/PRKDC/BCL2 3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 3/998 29/18722 0.199361170103763 0.489588273335724 YES1/MAPK14/PLK2 3 GO:0009310 amine catabolic process 3/998 29/18722 0.199361170103763 0.489588273335724 ALDH7A1/ATP2B4/SLC44A1 3 GO:0010592 positive regulation of lamellipodium assembly 3/998 29/18722 0.199361170103763 0.489588273335724 WASF2/NCKAP1/OCLN 3 GO:0021522 spinal cord motor neuron differentiation 3/998 29/18722 0.199361170103763 0.489588273335724 LMO4/ISL1/GLI3 3 GO:0032366 intracellular sterol transport 3/998 29/18722 0.199361170103763 0.489588273335724 ABCA1/SYT7/ANXA2 3 GO:0032367 intracellular cholesterol transport 3/998 29/18722 0.199361170103763 0.489588273335724 ABCA1/SYT7/ANXA2 3 GO:0033028 myeloid cell apoptotic process 3/998 29/18722 0.199361170103763 0.489588273335724 CTSL/PIK3CB/BCL2 3 GO:0034311 diol metabolic process 3/998 29/18722 0.199361170103763 0.489588273335724 PLPP3/SPTLC3/SGPP1 3 GO:0048665 neuron fate specification 3/998 29/18722 0.199361170103763 0.489588273335724 ISL1/GLI3/ESRP1 3 GO:0060969 negative regulation of gene silencing 3/998 29/18722 0.199361170103763 0.489588273335724 KCNQ1OT1/LIN28B/PPARG 3 GO:0090114 COPII-coated vesicle budding 3/998 29/18722 0.199361170103763 0.489588273335724 SEC31A/MIA3/TFG 3 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/998 29/18722 0.199361170103763 0.489588273335724 PTTG1IP/MDM2/BCL2 3 GO:1903902 positive regulation of viral life cycle 3/998 29/18722 0.199361170103763 0.489588273335724 DDB1/P4HB/FMR1 3 GO:0006325 chromatin organization 26/998 409/18722 0.202204786005115 0.496338123052518 SMARCA2/BRD4/DNMT1/SMARCA1/RERE/CBX4/DNMT3A/KDM5B/ATRX/TPR/RBBP7/BPTF/TP63/MPHOSPH8/TLK1/SMARCA5/AEBP2/SETD2/HP1BP3/BAZ1B/SMARCC1/GATA3/KDM4B/CHD6/HDAC2/HNRNPU 26 GO:0007611 learning or memory 17/998 255/18722 0.203139386398575 0.498397902437481 EGFR/APP/MME/SLC6A4/SERPINF1/ITGB1/NF1/ARL6IP5/CLN3/NCSTN/TPBG/KRAS/EIF2AK4/GM2A/PLK2/MEIS2/SHANK2 17 GO:0072329 monocarboxylic acid catabolic process 9/998 122/18722 0.203256920410754 0.498452034506597 SLC27A2/HADHA/CROT/ECHDC2/ACADVL/ECI2/CPT2/ECHDC1/ETFA 9 GO:0030901 midbrain development 7/998 90/18722 0.203732198887207 0.49891454521112 WLS/HSPA5/DLG5/RYK/FZD6/FGFR2/CTNNB1 7 GO:0035304 regulation of protein dephosphorylation 7/998 90/18722 0.203732198887207 0.49891454521112 HSP90B1/SLC39A10/SWAP70/BOD1L1/SPPL3/GSK3B/PPP6R2 7 GO:0061097 regulation of protein tyrosine kinase activity 7/998 90/18722 0.203732198887207 0.49891454521112 APP/CD24/ERBB3/EFNA1/PTPN1/ERRFI1/NEDD9 7 GO:0018108 peptidyl-tyrosine phosphorylation 24/998 375/18722 0.204160176505336 0.49962666819569 EGFR/APP/MET/EFEMP1/NRP1/IGF1R/CD24/PRLR/EPHB4/IL6ST/ERBB3/ISL1/EFNA1/YES1/SUZ12/WEE1/PTPN1/ERRFI1/FGFR2/BAZ1B/DDR1/NEDD9/PTK2/HDAC2 24 GO:0034614 cellular response to reactive oxygen species 11/998 155/18722 0.205099829199324 0.49962666819569 EGFR/MET/BMP7/NET1/MDM2/STK26/PAWR/PLEKHA1/SOD3/HDAC2/NFE2L2 11 GO:0051147 regulation of muscle cell differentiation 11/998 155/18722 0.205099829199324 0.49962666819569 DNMT1/FOXO4/MDM2/ANKRD17/MAPK14/FGFR2/BHLHE41/MMP14/BCL2/PDCD4/YY1 11 GO:0006406 mRNA export from nucleus 5/998 59/18722 0.205202878828508 0.49962666819569 TPR/SETD2/AGFG1/PABPN1/HNRNPA2B1 5 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 5/998 59/18722 0.205202878828508 0.49962666819569 TPR/SETD2/AGFG1/PABPN1/HNRNPA2B1 5 GO:2000351 regulation of endothelial cell apoptotic process 5/998 59/18722 0.205202878828508 0.49962666819569 ANO6/PRKCI/GATA3/PDCD4/NFE2L2 5 GO:0005978 glycogen biosynthetic process 4/998 44/18722 0.205980900815041 0.49962666819569 AGL/UGP2/SORBS1/GSK3B 4 GO:0009250 glucan biosynthetic process 4/998 44/18722 0.205980900815041 0.49962666819569 AGL/UGP2/SORBS1/GSK3B 4 GO:0032881 regulation of polysaccharide metabolic process 4/998 44/18722 0.205980900815041 0.49962666819569 CLTC/SORBS1/GSK3B/PHLDA2 4 GO:0045124 regulation of bone resorption 4/998 44/18722 0.205980900815041 0.49962666819569 EGFR/TFRC/NF1/LTBP3 4 GO:0050999 regulation of nitric-oxide synthase activity 4/998 44/18722 0.205980900815041 0.49962666819569 EGFR/ATP2B4/PIK3CB/KRAS 4 GO:0051403 stress-activated MAPK cascade 16/998 239/18722 0.207288180437577 0.49962666819569 EGFR/APP/HACD3/DLG1/IGF1R/ARL6IP5/MAP3K4/TLR3/MARVELD3/DUSP9/EZR/MAPK14/PDCD4/EMC10/MAP3K13/PAGE4 16 GO:0001977 renal system process involved in regulation of blood volume 2/998 16/18722 0.208712078784677 0.49962666819569 GJA1/GJA5 2 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/998 16/18722 0.208712078784677 0.49962666819569 MME/ENPEP 2 GO:0002093 auditory receptor cell morphogenesis 2/998 16/18722 0.208712078784677 0.49962666819569 MYO7A/TRIOBP 2 GO:0002693 positive regulation of cellular extravasation 2/998 16/18722 0.208712078784677 0.49962666819569 CD47/JAM3 2 GO:0002713 negative regulation of B cell mediated immunity 2/998 16/18722 0.208712078784677 0.49962666819569 CD46/CD55 2 GO:0002890 negative regulation of immunoglobulin mediated immune response 2/998 16/18722 0.208712078784677 0.49962666819569 CD46/CD55 2 GO:0005980 glycogen catabolic process 2/998 16/18722 0.208712078784677 0.49962666819569 AGL/GAA 2 GO:0006004 fucose metabolic process 2/998 16/18722 0.208712078784677 0.49962666819569 FUT8/FUCA1 2 GO:0006555 methionine metabolic process 2/998 16/18722 0.208712078784677 0.49962666819569 MTR/SMS 2 GO:0006857 oligopeptide transport 2/998 16/18722 0.208712078784677 0.49962666819569 GJA1/SLC13A3 2 GO:0007635 chemosensory behavior 2/998 16/18722 0.208712078784677 0.49962666819569 ATP6V1B1/TPBG 2 GO:0009048 dosage compensation by inactivation of X chromosome 2/998 16/18722 0.208712078784677 0.49962666819569 HNRNPU/XIST 2 GO:0009415 response to water 2/998 16/18722 0.208712078784677 0.49962666819569 ATP2B4/PLEC 2 GO:0030540 female genitalia development 2/998 16/18722 0.208712078784677 0.49962666819569 LRP2/TP63 2 GO:0032274 gonadotropin secretion 2/998 16/18722 0.208712078784677 0.49962666819569 GJA1/TMF1 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/998 16/18722 0.208712078784677 0.49962666819569 BMP7/GCNT2 2 GO:0034138 toll-like receptor 3 signaling pathway 2/998 16/18722 0.208712078784677 0.49962666819569 COLEC12/TLR3 2 GO:0034393 positive regulation of smooth muscle cell apoptotic process 2/998 16/18722 0.208712078784677 0.49962666819569 PPARG/PDCD4 2 GO:0045838 positive regulation of membrane potential 2/998 16/18722 0.208712078784677 0.49962666819569 ANK3/VCP 2 GO:0050884 neuromuscular process controlling posture 2/998 16/18722 0.208712078784677 0.49962666819569 TMEM150C/GAA 2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 2/998 16/18722 0.208712078784677 0.49962666819569 NRDC/SH3D19 2 GO:0060004 reflex 2/998 16/18722 0.208712078784677 0.49962666819569 AFG3L2/ALDH1A3 2 GO:0070242 thymocyte apoptotic process 2/998 16/18722 0.208712078784677 0.49962666819569 EFNA1/GLI3 2 GO:0071391 cellular response to estrogen stimulus 2/998 16/18722 0.208712078784677 0.49962666819569 MDM2/TRIM24 2 GO:0080009 mRNA methylation 2/998 16/18722 0.208712078784677 0.49962666819569 ZC3H13/CMTR1 2 GO:0097202 activation of cysteine-type endopeptidase activity 2/998 16/18722 0.208712078784677 0.49962666819569 ASPH/PERP 2 GO:0097284 hepatocyte apoptotic process 2/998 16/18722 0.208712078784677 0.49962666819569 DNMT3A/KRT18 2 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/998 16/18722 0.208712078784677 0.49962666819569 CLSTN1/NSG1 2 GO:0099633 protein localization to postsynaptic specialization membrane 2/998 16/18722 0.208712078784677 0.49962666819569 DAG1/DLG1 2 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 2/998 16/18722 0.208712078784677 0.49962666819569 DAG1/DLG1 2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 2/998 16/18722 0.208712078784677 0.49962666819569 SEMA6A/PIK3CB 2 GO:1901201 regulation of extracellular matrix assembly 2/998 16/18722 0.208712078784677 0.49962666819569 DAG1/PHLDB2 2 GO:1904948 midbrain dopaminergic neuron differentiation 2/998 16/18722 0.208712078784677 0.49962666819569 RYK/CTNNB1 2 GO:1905153 regulation of membrane invagination 2/998 16/18722 0.208712078784677 0.49962666819569 ANO6/RAB31 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/998 16/18722 0.208712078784677 0.49962666819569 ZNRF3/GPC3 2 GO:2000765 regulation of cytoplasmic translation 2/998 16/18722 0.208712078784677 0.49962666819569 FMR1/DHX36 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/998 16/18722 0.208712078784677 0.49962666819569 PRKDC/RIF1 2 GO:0031570 DNA integrity checkpoint signaling 9/998 123/18722 0.209758498466954 0.501845911839776 FOXO4/PRKDC/MDM2/CCND1/EIF2AK4/MAPK14/PLK2/XPC/PPP1R10 9 GO:0033077 T cell differentiation in thymus 6/998 75/18722 0.209831378193111 0.501845911839776 PRKDC/GLI3/CTNNB1/FZD5/GATA3/BCL2 6 GO:0009267 cellular response to starvation 11/998 156/18722 0.210860213787225 0.504075630120468 SLC2A1/HSPA5/CTSV/STK26/GABARAPL1/EIF2AK4/SLC38A2/BCL2/TNRC6A/PMAIP1/NFE2L2 11 GO:0000132 establishment of mitotic spindle orientation 3/998 30/18722 0.213379683397606 0.508701062565707 ITGB1/GJA1/GPSM2 3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/998 30/18722 0.213379683397606 0.508701062565707 APP/BMP7/S1PR2 3 GO:0034390 smooth muscle cell apoptotic process 3/998 30/18722 0.213379683397606 0.508701062565707 DNMT1/PPARG/PDCD4 3 GO:0034391 regulation of smooth muscle cell apoptotic process 3/998 30/18722 0.213379683397606 0.508701062565707 DNMT1/PPARG/PDCD4 3 GO:0051125 regulation of actin nucleation 3/998 30/18722 0.213379683397606 0.508701062565707 SCIN/WASF2/NCKAP1 3 GO:0070229 negative regulation of lymphocyte apoptotic process 3/998 30/18722 0.213379683397606 0.508701062565707 SLC39A10/EFNA1/DOCK8 3 GO:0051216 cartilage development 13/998 190/18722 0.214720339575115 0.511663575044123 EFEMP1/BMP7/ITGB8/GLG1/TRIP11/SERPINH1/SCIN/GLI3/CREB3L2/TGFBR1/MAPK14/CTNNB1/LTBP3 13 GO:1990845 adaptive thermogenesis 11/998 157/18722 0.216687938684493 0.515703006877686 ADRB1/GJA1/LGR4/IGF1R/PRLR/DYNC1H1/ESRRG/CPT2/NRDC/HNRNPU/GNAS 11 GO:0003009 skeletal muscle contraction 4/998 45/18722 0.217304465644687 0.515703006877686 DMD/HOMER1/GAA/ATP2A2 4 GO:0003197 endocardial cushion development 4/998 45/18722 0.217304465644687 0.515703006877686 BMP7/MDM2/ISL1/TGFBR1 4 GO:0031670 cellular response to nutrient 4/998 45/18722 0.217304465644687 0.515703006877686 ATP2B1/MDM2/FOLR1/TRIM24 4 GO:0042551 neuron maturation 4/998 45/18722 0.217304465644687 0.515703006877686 APP/NRCAM/BCL2/MAP3K13 4 GO:0060421 positive regulation of heart growth 4/998 45/18722 0.217304465644687 0.515703006877686 TGFBR3/YAP1/MAPK14/FGFR2 4 GO:0085029 extracellular matrix assembly 4/998 45/18722 0.217304465644687 0.515703006877686 LAMB1/DAG1/LTBP3/PHLDB2 4 GO:1901985 positive regulation of protein acetylation 4/998 45/18722 0.217304465644687 0.515703006877686 ISL1/RPS6KA5/BRD7/GATA3 4 GO:2000273 positive regulation of signaling receptor activity 4/998 45/18722 0.217304465644687 0.515703006877686 NRP1/NCOA3/ITGB1/HDAC2 4 GO:0007173 epidermal growth factor receptor signaling pathway 8/998 108/18722 0.218242138933046 0.516886554218947 EGFR/EFEMP1/IFI6/GAB1/RPS6KA5/GAREM1/ERRFI1/PTK2 8 GO:0033138 positive regulation of peptidyl-serine phosphorylation 8/998 108/18722 0.218242138933046 0.516886554218947 EGFR/APP/TFRC/AKAP9/ATP2B4/EIF4G1/HSP90AA1/BCL2 8 GO:0001937 negative regulation of endothelial cell proliferation 6/998 76/18722 0.218397191841984 0.516886554218947 GJA1/NR2F2/NF1/TGFBR1/PPARG/PTPRM 6 GO:0014823 response to activity 6/998 76/18722 0.218397191841984 0.516886554218947 PRKDC/HSPD1/COL4A2/ALAD/UQCRC1/TOMM20 6 GO:0031100 animal organ regeneration 6/998 76/18722 0.218397191841984 0.516886554218947 EGFR/TGFBR3/GLI3/SRSF5/CCND1/ANXA3 6 GO:0071426 ribonucleoprotein complex export from nucleus 6/998 76/18722 0.218397191841984 0.516886554218947 TPR/SETD2/LSG1/AGFG1/PABPN1/HNRNPA2B1 6 GO:0001708 cell fate specification 7/998 92/18722 0.219137923728287 0.517466802254811 NRP1/ITGB1/LMO4/ISL1/GLI3/ESRP1/CTNNB1 7 GO:0032465 regulation of cytokinesis 7/998 92/18722 0.219137923728287 0.517466802254811 BIRC6/SETD2/UVRAG/PKN2/RAB11FIP4/PLK2/PRPF40A 7 GO:0034502 protein localization to chromosome 7/998 92/18722 0.219137923728287 0.517466802254811 ATRX/SETD2/RAD21/VCP/TNKS2/WAPL/NIPBL 7 GO:1903312 negative regulation of mRNA metabolic process 7/998 92/18722 0.219137923728287 0.517466802254811 FUS/FMR1/MAPK14/SECISBP2/ZC3H14/SRSF4/HNRNPU 7 GO:1903351 cellular response to dopamine 7/998 92/18722 0.219137923728287 0.517466802254811 TGM2/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 7 GO:0048284 organelle fusion 10/998 141/18722 0.220020060971219 0.519314981162177 TFRC/EEA1/VAV3/SYT7/HUWE1/CLN3/AFG3L2/UVRAG/USO1/ANXA2 10 GO:1903320 regulation of protein modification by small protein conjugation or removal 16/998 242/18722 0.221301999944451 0.522104718350646 HSPA5/SKP2/PTTG1IP/TRIM44/HUWE1/UFL1/SIAH2/NDFIP2/MYCBP2/TGFBR1/HSP90AA1/VCP/CTNNB1/UBR5/HSPA1B/OTUD4 16 GO:0051053 negative regulation of DNA metabolic process 9/998 125/18722 0.223006481445681 0.525413736294178 GJA1/PARP1/RAD50/DCP2/RIF1/TNKS2/GATA3/UBR5/HNRNPU 9 GO:0055007 cardiac muscle cell differentiation 9/998 125/18722 0.223006481445681 0.525413736294178 ITGB1/CALR/ISL1/OBSL1/SLC9A1/PLEC/YY1/LMNA/HNRNPU 9 GO:0070585 protein localization to mitochondrion 9/998 125/18722 0.223006481445681 0.525413736294178 LMAN1/HSPD1/HUWE1/LEPROT/NPEPPS/HSP90AA1/BCAP31/FZD5/TOMM20 9 GO:0051591 response to cAMP 7/998 93/18722 0.226992723078532 0.526683716074271 APP/AKAP9/HSPA5/BSG/EZR/CDO1/ASS1 7 GO:1903350 response to dopamine 7/998 93/18722 0.226992723078532 0.526683716074271 TGM2/NCSTN/GSK3B/HDAC2/VPS35/NSG1/GNAS 7 GO:0002200 somatic diversification of immune receptors 6/998 77/18722 0.227078422749 0.526683716074271 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0071166 ribonucleoprotein complex localization 6/998 77/18722 0.227078422749 0.526683716074271 TPR/SETD2/LSG1/AGFG1/PABPN1/HNRNPA2B1 6 GO:0002230 positive regulation of defense response to virus by host 3/998 31/18722 0.227599993256739 0.526683716074271 TRIM44/HSP90AA1/EIF2AK4 3 GO:0006613 cotranslational protein targeting to membrane 3/998 31/18722 0.227599993256739 0.526683716074271 SIL1/TRAM2/SEC63 3 GO:0007190 activation of adenylate cyclase activity 3/998 31/18722 0.227599993256739 0.526683716074271 LGR5/ADRB1/LGR4 3 GO:0008045 motor neuron axon guidance 3/998 31/18722 0.227599993256739 0.526683716074271 NRP1/MYCBP2/SEMA3F 3 GO:0030149 sphingolipid catabolic process 3/998 31/18722 0.227599993256739 0.526683716074271 HEXB/HEXA/GM2A 3 GO:0048566 embryonic digestive tract development 3/998 31/18722 0.227599993256739 0.526683716074271 GLI3/FGFR2/NIPBL 3 GO:0051569 regulation of histone H3-K4 methylation 3/998 31/18722 0.227599993256739 0.526683716074271 DNMT1/CTNNB1/GATA3 3 GO:0055022 negative regulation of cardiac muscle tissue growth 3/998 31/18722 0.227599993256739 0.526683716074271 GJA1/VGLL4/YY1 3 GO:0061117 negative regulation of heart growth 3/998 31/18722 0.227599993256739 0.526683716074271 GJA1/VGLL4/YY1 3 GO:0065005 protein-lipid complex assembly 3/998 31/18722 0.227599993256739 0.526683716074271 ABCA1/LPCAT3/ACSL3 3 GO:0070633 transepithelial transport 3/998 31/18722 0.227599993256739 0.526683716074271 SLC1A3/AHCYL1/ABCB1 3 GO:0070723 response to cholesterol 3/998 31/18722 0.227599993256739 0.526683716074271 DAG1/ABCA1/TGFBR1 3 GO:0071480 cellular response to gamma radiation 3/998 31/18722 0.227599993256739 0.526683716074271 HSPA5/YAP1/MDM2 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/998 31/18722 0.227599993256739 0.526683716074271 PTTG1IP/MDM2/BCL2 3 GO:0000097 sulfur amino acid biosynthetic process 2/998 17/18722 0.228709126907066 0.526683716074271 MTR/CDO1 2 GO:0001780 neutrophil homeostasis 2/998 17/18722 0.228709126907066 0.526683716074271 PIK3CB/JAM3 2 GO:0006901 vesicle coating 2/998 17/18722 0.228709126907066 0.526683716074271 TMED9/TFG 2 GO:0007379 segment specification 2/998 17/18722 0.228709126907066 0.526683716074271 COBL/IRX2 2 GO:0008340 determination of adult lifespan 2/998 17/18722 0.228709126907066 0.526683716074271 TFCP2L1/PRDM2 2 GO:0009251 glucan catabolic process 2/998 17/18722 0.228709126907066 0.526683716074271 AGL/GAA 2 GO:0010470 regulation of gastrulation 2/998 17/18722 0.228709126907066 0.526683716074271 DAG1/PHLDB2 2 GO:0010831 positive regulation of myotube differentiation 2/998 17/18722 0.228709126907066 0.526683716074271 MAPK14/MMP14 2 GO:0015867 ATP transport 2/998 17/18722 0.228709126907066 0.526683716074271 GJA1/CD47 2 GO:0021756 striatum development 2/998 17/18722 0.228709126907066 0.526683716074271 ALDH1A3/SECISBP2 2 GO:0021924 cell proliferation in external granule layer 2/998 17/18722 0.228709126907066 0.526683716074271 SLC6A4/RERE 2 GO:0021930 cerebellar granule cell precursor proliferation 2/998 17/18722 0.228709126907066 0.526683716074271 SLC6A4/RERE 2 GO:0033151 V(D)J recombination 2/998 17/18722 0.228709126907066 0.526683716074271 PRKDC/YY1 2 GO:0035269 protein O-linked mannosylation 2/998 17/18722 0.228709126907066 0.526683716074271 TMTC3/B4GAT1 2 GO:0036035 osteoclast development 2/998 17/18722 0.228709126907066 0.526683716074271 FBN1/ANXA2 2 GO:0038065 collagen-activated signaling pathway 2/998 17/18722 0.228709126907066 0.526683716074271 COL4A2/DDR1 2 GO:0043117 positive regulation of vascular permeability 2/998 17/18722 0.228709126907066 0.526683716074271 TJP1/OCLN 2 GO:0045198 establishment of epithelial cell apical/basal polarity 2/998 17/18722 0.228709126907066 0.526683716074271 FAT1/OPHN1 2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 2/998 17/18722 0.228709126907066 0.526683716074271 SYT7/ATP2A2 2 GO:0055064 chloride ion homeostasis 2/998 17/18722 0.228709126907066 0.526683716074271 SLC12A9/ATP6V1B1 2 GO:0055083 monovalent inorganic anion homeostasis 2/998 17/18722 0.228709126907066 0.526683716074271 SLC12A9/ATP6V1B1 2 GO:0055119 relaxation of cardiac muscle 2/998 17/18722 0.228709126907066 0.526683716074271 P2RX4/ATP2A2 2 GO:0061298 retina vasculature development in camera-type eye 2/998 17/18722 0.228709126907066 0.526683716074271 NRP1/LRP5 2 GO:0070293 renal absorption 2/998 17/18722 0.228709126907066 0.526683716074271 CLDN4/MAGED2 2 GO:0072673 lamellipodium morphogenesis 2/998 17/18722 0.228709126907066 0.526683716074271 KANK1/WASF2 2 GO:0090399 replicative senescence 2/998 17/18722 0.228709126907066 0.526683716074271 MME/PLA2R1 2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 2/998 17/18722 0.228709126907066 0.526683716074271 AKAP9/HOMER1 2 GO:1902358 sulfate transmembrane transport 2/998 17/18722 0.228709126907066 0.526683716074271 SLC26A2/SLC13A4 2 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 2/998 17/18722 0.228709126907066 0.526683716074271 PPARG/YY1 2 GO:1903540 establishment of protein localization to postsynaptic membrane 2/998 17/18722 0.228709126907066 0.526683716074271 CLSTN1/NSG1 2 GO:1903830 magnesium ion transmembrane transport 2/998 17/18722 0.228709126907066 0.526683716074271 TUSC3/ZDHHC17 2 GO:0006383 transcription by RNA polymerase III 4/998 46/18722 0.228791164155611 0.526683716074271 ICE1/DHX36/BDP1/ELL 4 GO:0010830 regulation of myotube differentiation 4/998 46/18722 0.228791164155611 0.526683716074271 MAPK14/BHLHE41/MMP14/BCL2 4 GO:0031648 protein destabilization 4/998 46/18722 0.228791164155611 0.526683716074271 PRKDC/MDM2/SIAH1/MYLIP 4 GO:0006401 RNA catabolic process 18/998 278/18722 0.229592708542973 0.52829595914626 KCNQ1OT1/LIN28B/FUS/SND1/TTC37/PUM1/LRPPRC/DCP2/FMR1/DICER1/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/HNRNPU 18 GO:0043534 blood vessel endothelial cell migration 12/998 176/18722 0.229978297769125 0.528950084868987 NRP1/ITGB1/NF1/AMOT/EPHB4/ATP2B4/EFNA1/P2RX4/MIA3/PPARG/PLK2/NFE2L2 12 GO:0071826 ribonucleoprotein complex subunit organization 15/998 227/18722 0.231170750663556 0.531239596467257 PRKDC/EIF3A/SF1/SRSF5/RBM5/DICER1/HSP90AA1/VCP/SF3B1/DDX1/AGO2/DENR/SNRNP200/PRPF8/LUC7L3 15 GO:0045637 regulation of myeloid cell differentiation 14/998 210/18722 0.231177238684851 0.531239596467257 FBN1/CSF3R/CDK6/PRKDC/SCIN/RCOR1/TLR3/MAPK14/CTNNB1/RBFOX2/HSPA1B/MEIS2/PURB/HSPA9 14 GO:0038061 NIK/NF-kappaB signaling 10/998 143/18722 0.232656988715361 0.534404812179015 EGFR/APP/BMP7/NFAT5/CALR/TRIM44/TLR3/DICER1/ACTN4/PDCD4 10 GO:0050890 cognition 19/998 296/18722 0.233076045062122 0.535131939872181 EGFR/APP/MME/TUSC3/SLC6A4/SERPINF1/ITGB1/NF1/ARL6IP5/CLN3/NCSTN/TPBG/KRAS/EIF2AK4/GM2A/PLK2/NIPBL/MEIS2/SHANK2 19 GO:0032615 interleukin-12 production 5/998 62/18722 0.234515919511434 0.537492368643195 CD47/HSPD1/ISL1/TLR3/MAPK14 5 GO:0032655 regulation of interleukin-12 production 5/998 62/18722 0.234515919511434 0.537492368643195 CD47/HSPD1/ISL1/TLR3/MAPK14 5 GO:0032835 glomerulus development 5/998 62/18722 0.234515919511434 0.537492368643195 BMP7/ENPEP/LGR4/CD24/BCL2 5 GO:0045428 regulation of nitric oxide biosynthetic process 5/998 62/18722 0.234515919511434 0.537492368643195 CD47/ATP2B4/P2RX4/HSP90AA1/ASS1 5 GO:0010389 regulation of G2/M transition of mitotic cell cycle 7/998 94/18722 0.234942566720773 0.53799786879349 APP/BRD4/PBX1/FOXO4/USP47/CCND1/RAD21 7 GO:0030316 osteoclast differentiation 7/998 94/18722 0.234942566720773 0.53799786879349 FBN1/TFRC/TLR3/MAPK14/CTNNB1/GPC3/ANXA2 7 GO:0009064 glutamine family amino acid metabolic process 6/998 78/18722 0.235868560281045 0.539881522677483 RIMKLB/ATP2B4/GFPT1/CLN3/ALDH18A1/ASS1 6 GO:1901654 response to ketone 13/998 194/18722 0.236283135269336 0.54059344839667 EGFR/ATP2B1/SERPINF1/CLDN4/PARP1/TGFBR3/CALR/YAP1/CCND1/ERRFI1/GNAI1/ASS1/GLB1 13 GO:0035270 endocrine system development 9/998 127/18722 0.236562524302386 0.540995593246938 CDH1/PBX1/CDK6/NF1/ISL1/TGFBR1/ARID5B/GATA3/GSK3B 9 GO:0010821 regulation of mitochondrion organization 10/998 144/18722 0.239075845261857 0.545787052082271 TFRC/PISD/HUWE1/PPARG/FZD5/INF2/GSK3B/PMAIP1/LMNA/VPS35 10 GO:0014065 phosphatidylinositol 3-kinase signaling 10/998 144/18722 0.239075845261857 0.545787052082271 EGFR/NF1/IGF1R/ERBB3/PLXNB1/NEDD4/PIK3CB/PLEKHA1/PTK2/GATA3 10 GO:0106106 cold-induced thermogenesis 10/998 144/18722 0.239075845261857 0.545787052082271 ADRB1/GJA1/LGR4/IGF1R/PRLR/DYNC1H1/ESRRG/CPT2/NRDC/GNAS 10 GO:0120161 regulation of cold-induced thermogenesis 10/998 144/18722 0.239075845261857 0.545787052082271 ADRB1/GJA1/LGR4/IGF1R/PRLR/DYNC1H1/ESRRG/CPT2/NRDC/GNAS 10 GO:0010712 regulation of collagen metabolic process 4/998 47/18722 0.240425246127782 0.547670248705563 ITGB1/SUCO/ERRFI1/HDAC2 4 GO:0016574 histone ubiquitination 4/998 47/18722 0.240425246127782 0.547670248705563 DDB1/HUWE1/USP22/UBR5 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/998 47/18722 0.240425246127782 0.547670248705563 CD24/YAP1/CTNNB1/GATA3 4 GO:0045911 positive regulation of DNA recombination 4/998 47/18722 0.240425246127782 0.547670248705563 TFRC/PARP1/FUS/RIF1 4 GO:1900744 regulation of p38MAPK cascade 4/998 47/18722 0.240425246127782 0.547670248705563 DLG1/MAP3K4/EZR/EMC10 4 GO:0006091 generation of precursor metabolites and energy 30/998 490/18722 0.24071292469944 0.547892102948257 APP/AGL/ACSS1/GLDC/DEGS1/ASPH/IL10RB/IDH1/IL6ST/OPN3/GFPT1/PHKB/CROT/UGP2/ACADVL/RPIA/SORBS1/VCP/GAA/CYB5A/ADH5/PLEC/ACO1/PDIA5/GSK3B/ETFA/PHLDA2/UQCRC1/NDUFB9/COX6A1 30 GO:0035265 organ growth 12/998 178/18722 0.241487961327485 0.547892102948257 SLC6A4/GJA1/TGFBR3/YAP1/DUSP9/LATS2/TGFBR1/MAPK14/FGFR2/VGLL4/BCL2/YY1 12 GO:0048015 phosphatidylinositol-mediated signaling 12/998 178/18722 0.241487961327485 0.547892102948257 EGFR/NF1/IGF1R/ERBB3/EXOC1/PLXNB1/EZR/NEDD4/PIK3CB/PLEKHA1/PTK2/GATA3 12 GO:0030258 lipid modification 14/998 212/18722 0.241706117948842 0.547892102948257 SLC27A2/PLPP3/HADHA/LPCAT3/CROT/ECHDC2/ACADVL/ECI2/CPT2/MAPK14/ADH5/ECHDC1/SGPP1/ETFA 14 GO:1901605 alpha-amino acid metabolic process 13/998 195/18722 0.24180402162811 0.547892102948257 GLDC/RIMKLB/ATP2B4/MTR/GFPT1/CLN3/SMS/CDO1/AASDHPPT/ALDH18A1/AZIN1/ASS1/SERINC3 13 GO:0003338 metanephros morphogenesis 3/998 32/18722 0.241991800306202 0.547892102948257 LGR4/FRAS1/CTNNB1 3 GO:0010743 regulation of macrophage derived foam cell differentiation 3/998 32/18722 0.241991800306202 0.547892102948257 ITGAV/ABCA1/PPARG 3 GO:0019228 neuronal action potential 3/998 32/18722 0.241991800306202 0.547892102948257 ANK3/FMR1/P2RX4 3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 3/998 32/18722 0.241991800306202 0.547892102948257 TGFBR3/FERMT1/CDKN1C 3 GO:0035767 endothelial cell chemotaxis 3/998 32/18722 0.241991800306202 0.547892102948257 MET/NRP1/P2RX4 3 GO:0050850 positive regulation of calcium-mediated signaling 3/998 32/18722 0.241991800306202 0.547892102948257 SLC9A1/P2RX4/SPPL3 3 GO:0090140 regulation of mitochondrial fission 3/998 32/18722 0.241991800306202 0.547892102948257 PPARG/INF2/VPS35 3 GO:1901889 negative regulation of cell junction assembly 3/998 32/18722 0.241991800306202 0.547892102948257 LRP1/MMP14/PHLDB2 3 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 3/998 32/18722 0.241991800306202 0.547892102948257 TGFBR3/FERMT1/CDKN1C 3 GO:1901379 regulation of potassium ion transmembrane transport 7/998 95/18722 0.242982681600324 0.549897087401513 AKAP9/ITGB1/DLG1/ANO6/ANK3/KCNN4/NEDD4 7 GO:0033865 nucleoside bisphosphate metabolic process 9/998 128/18722 0.243448966210145 0.550236819300073 SLC26A2/ACSS1/TPST2/CROT/ACSF2/ACSL3/FASN/FAR1/TECR 9 GO:0033875 ribonucleoside bisphosphate metabolic process 9/998 128/18722 0.243448966210145 0.550236819300073 SLC26A2/ACSS1/TPST2/CROT/ACSF2/ACSL3/FASN/FAR1/TECR 9 GO:0034032 purine nucleoside bisphosphate metabolic process 9/998 128/18722 0.243448966210145 0.550236819300073 SLC26A2/ACSS1/TPST2/CROT/ACSF2/ACSL3/FASN/FAR1/TECR 9 GO:0032233 positive regulation of actin filament bundle assembly 5/998 63/18722 0.244539075613913 0.551745252281868 NRP1/CD47/FERMT2/TGFBR1/SWAP70 5 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 5/998 63/18722 0.244539075613913 0.551745252281868 ERP29/PTPN1/BCL2/SERINC3/PMAIP1 5 GO:1902373 negative regulation of mRNA catabolic process 5/998 63/18722 0.244539075613913 0.551745252281868 FUS/FMR1/MAPK14/SECISBP2/HNRNPU 5 GO:2000242 negative regulation of reproductive process 5/998 63/18722 0.244539075613913 0.551745252281868 BMP7/SERPINF1/GJA1/CALR/PRDX4 5 GO:0031098 stress-activated protein kinase signaling cascade 16/998 247/18722 0.245535399846264 0.553285117283922 EGFR/APP/HACD3/DLG1/IGF1R/ARL6IP5/MAP3K4/TLR3/MARVELD3/DUSP9/EZR/MAPK14/PDCD4/EMC10/MAP3K13/PAGE4 16 GO:0002821 positive regulation of adaptive immune response 8/998 112/18722 0.247537394750579 0.553285117283922 TFRC/CD55/IL6ST/HSPD1/EIF2AK4/RIF1/FZD5/GATA3 8 GO:1903532 positive regulation of secretion by cell 18/998 282/18722 0.247898061583776 0.553285117283922 EGFR/MYH10/WLS/SLC6A4/GJA1/LRP1/EXPH5/FRMD4A/KCNN4/ISL1/SYT7/EXOC1/CD2AP/EZR/P2RX4/TCF7L2/SNX4/TMF1 18 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 2/998 18/18722 0.248824641904357 0.553285117283922 CD46/CD55 2 GO:0003128 heart field specification 2/998 18/18722 0.248824641904357 0.553285117283922 LRP2/ISL1 2 GO:0006595 polyamine metabolic process 2/998 18/18722 0.248824641904357 0.553285117283922 SMS/AZIN1 2 GO:0007549 dosage compensation 2/998 18/18722 0.248824641904357 0.553285117283922 HNRNPU/XIST 2 GO:0008272 sulfate transport 2/998 18/18722 0.248824641904357 0.553285117283922 SLC26A2/SLC13A4 2 GO:0009404 toxin metabolic process 2/998 18/18722 0.248824641904357 0.553285117283922 ARL1/NFE2L2 2 GO:0010985 negative regulation of lipoprotein particle clearance 2/998 18/18722 0.248824641904357 0.553285117283922 LRPAP1/MYLIP 2 GO:0015693 magnesium ion transport 2/998 18/18722 0.248824641904357 0.553285117283922 TUSC3/ZDHHC17 2 GO:0021534 cell proliferation in hindbrain 2/998 18/18722 0.248824641904357 0.553285117283922 SLC6A4/RERE 2 GO:0030299 intestinal cholesterol absorption 2/998 18/18722 0.248824641904357 0.553285117283922 LIMA1/LPCAT3 2 GO:0032305 positive regulation of icosanoid secretion 2/998 18/18722 0.248824641904357 0.553285117283922 PLA2R1/P2RX4 2 GO:0036507 protein demannosylation 2/998 18/18722 0.248824641904357 0.553285117283922 MAN1A2/EDEM3 2 GO:0036508 protein alpha-1,2-demannosylation 2/998 18/18722 0.248824641904357 0.553285117283922 MAN1A2/EDEM3 2 GO:0044247 cellular polysaccharide catabolic process 2/998 18/18722 0.248824641904357 0.553285117283922 AGL/GAA 2 GO:0048643 positive regulation of skeletal muscle tissue development 2/998 18/18722 0.248824641904357 0.553285117283922 CTNNB1/BCL2 2 GO:0060008 Sertoli cell differentiation 2/998 18/18722 0.248824641904357 0.553285117283922 CTSV/ATRX 2 GO:0060602 branch elongation of an epithelium 2/998 18/18722 0.248824641904357 0.553285117283922 YAP1/FGFR2 2 GO:0060749 mammary gland alveolus development 2/998 18/18722 0.248824641904357 0.553285117283922 CCND1/DDR1 2 GO:0060973 cell migration involved in heart development 2/998 18/18722 0.248824641904357 0.553285117283922 BMP7/FOLR1 2 GO:0061377 mammary gland lobule development 2/998 18/18722 0.248824641904357 0.553285117283922 CCND1/DDR1 2 GO:0071071 regulation of phospholipid biosynthetic process 2/998 18/18722 0.248824641904357 0.553285117283922 IDH1/ACSL3 2 GO:0071318 cellular response to ATP 2/998 18/18722 0.248824641904357 0.553285117283922 HSP90B1/P2RX4 2 GO:0071360 cellular response to exogenous dsRNA 2/998 18/18722 0.248824641904357 0.553285117283922 COLEC12/TLR3 2 GO:0071786 endoplasmic reticulum tubular network organization 2/998 18/18722 0.248824641904357 0.553285117283922 REEP3/RTN4 2 GO:0072234 metanephric nephron tubule development 2/998 18/18722 0.248824641904357 0.553285117283922 LGR4/YAP1 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/998 18/18722 0.248824641904357 0.553285117283922 MAGED1/LGR4 2 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/998 18/18722 0.248824641904357 0.553285117283922 DHX36/AGO2 2 GO:1902001 fatty acid transmembrane transport 2/998 18/18722 0.248824641904357 0.553285117283922 SLC2A1/CPT2 2 GO:1903209 positive regulation of oxidative stress-induced cell death 2/998 18/18722 0.248824641904357 0.553285117283922 SFPQ/PAWR 2 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 2/998 18/18722 0.248824641904357 0.553285117283922 ISL1/CTNNB1 2 GO:2000641 regulation of early endosome to late endosome transport 2/998 18/18722 0.248824641904357 0.553285117283922 EZR/RDX 2 GO:0010506 regulation of autophagy 20/998 317/18722 0.249227734739733 0.553945510036672 MET/EXOC1/ATP6V1C2/ATP6V1B1/CLN3/USP10/UFL1/EIF4G1/TMEM59/NEDD4/PIK3CB/UVRAG/FZD5/BCL2/GOLGA2/PLK2/GSK3B/ATF6/TAB3/VPS35 20 GO:0003073 regulation of systemic arterial blood pressure 7/998 96/18722 0.251108236489232 0.557413308975459 MME/ADRB1/ENPEP/GJA1/NR2F2/GJA5/NAV2 7 GO:0030510 regulation of BMP signaling pathway 7/998 96/18722 0.251108236489232 0.557413308975459 FBN1/LRP2/CRIM1/TRIM33/FSTL1/PPARG/GPC3 7 GO:0035282 segmentation 7/998 96/18722 0.251108236489232 0.557413308975459 NRP2/NRP1/PRKDC/COBL/IRX2/SEMA3F/FZD5 7 GO:0042542 response to hydrogen peroxide 10/998 146/18722 0.252102575705084 0.558866613832846 MET/NET1/HSPD1/MDM2/STK26/PAWR/PLEKHA1/BCL2/HDAC2/NFE2L2 10 GO:0006111 regulation of gluconeogenesis 4/998 48/18722 0.252191101741081 0.558866613832846 DDB1/SLC35B4/FAM3C/RANBP2 4 GO:0010569 regulation of double-strand break repair via homologous recombination 4/998 48/18722 0.252191101741081 0.558866613832846 PARP1/FUS/SETD2/RIF1 4 GO:0048146 positive regulation of fibroblast proliferation 4/998 48/18722 0.252191101741081 0.558866613832846 CDK6/PRKDC/WAPL/ANXA2 4 GO:0042594 response to starvation 13/998 197/18722 0.252992106762773 0.560403813919576 SLC2A1/HSPA5/CTSV/EIF2AK1/STK26/GABARAPL1/EIF2AK4/SLC38A2/BCL2/TNRC6A/PMAIP1/NFE2L2/PAGE4 13 GO:0071897 DNA biosynthetic process 12/998 180/18722 0.253210269489736 0.560649201444407 GJA1/RAD50/MAP3K4/USP10/DCP2/PKIB/HSP90AA1/VCP/CTNNB1/TNKS2/HNRNPU/HNRNPA2B1 12 GO:0071229 cellular response to acid chemical 6/998 80/18722 0.253749193588116 0.56160429831435 SLC38A9/DNMT1/DNMT3A/ASS1/PLEC/COL5A2 6 GO:0006066 alcohol metabolic process 22/998 353/18722 0.253990979386752 0.561901230245014 APP/ACSS1/LRP5/SLC5A3/ISYNA1/NUDT4/IDH1/LIMA1/PLPP3/ABCA1/LPCAT3/ACADVL/MBTPS1/DHCR24/NFE2L1/SPTLC3/FDFT1/HDLBP/ADH5/ALDH1A3/SGPP1/SQLE 22 GO:0017156 calcium-ion regulated exocytosis 5/998 64/18722 0.254672188792816 0.562692974053023 SCIN/SYT7/TRPV6/SDF4/ATP2A2 5 GO:0030888 regulation of B cell proliferation 5/998 64/18722 0.254672188792816 0.562692974053023 TFRC/SLC39A10/VAV3/PAWR/BCL2 5 GO:0080164 regulation of nitric oxide metabolic process 5/998 64/18722 0.254672188792816 0.562692974053023 CD47/ATP2B4/P2RX4/HSP90AA1/ASS1 5 GO:0010165 response to X-ray 3/998 33/18722 0.256525805698904 0.564637955967107 CCND1/GATA3/NIPBL 3 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 3/998 33/18722 0.256525805698904 0.564637955967107 EPN2/NEDD4/PTPN1 3 GO:0033198 response to ATP 3/998 33/18722 0.256525805698904 0.564637955967107 HSP90B1/HSPD1/P2RX4 3 GO:0034110 regulation of homotypic cell-cell adhesion 3/998 33/18722 0.256525805698904 0.564637955967107 ANK3/IL6ST/RDX 3 GO:0045648 positive regulation of erythrocyte differentiation 3/998 33/18722 0.256525805698904 0.564637955967107 PRKDC/MAPK14/HSPA1B 3 GO:0060122 inner ear receptor cell stereocilium organization 3/998 33/18722 0.256525805698904 0.564637955967107 TRIP11/MYO7A/TRIOBP 3 GO:0071539 protein localization to centrosome 3/998 33/18722 0.256525805698904 0.564637955967107 GOLGB1/PCM1/GSK3B 3 GO:0099174 regulation of presynapse organization 3/998 33/18722 0.256525805698904 0.564637955967107 APP/EIF4G1/VPS35 3 GO:1905606 regulation of presynapse assembly 3/998 33/18722 0.256525805698904 0.564637955967107 APP/EIF4G1/VPS35 3 GO:0030534 adult behavior 9/998 130/18722 0.257424058496715 0.566376320864454 APP/PUM1/ATP6V1B1/HOMER1/NCSTN/EPS8/SHANK2/OXR1/HDAC2 9 GO:0060041 retina development in camera-type eye 10/998 147/18722 0.258705624083424 0.568956218761397 ATP2B1/NRP1/SERPINF1/LRP5/ATP2B4/TFAP2A/OBSL1/AHI1/PTPRM/MAN2A1 10 GO:1905952 regulation of lipid localization 12/998 181/18722 0.25914691035832 0.569575191817091 ITGAV/LRP1/ABCA1/LPCAT3/KDM5B/PLA2R1/P2RX4/PPARG/TMEM30A/HILPDA/TMF1/ANXA2 12 GO:0035335 peptidyl-tyrosine dephosphorylation 7/998 97/18722 0.25931435183858 0.569575191817091 PTPN14/PTP4A1/PTPN1/PTPRM/DUSP14/PTPRA/DUSP5 7 GO:0043255 regulation of carbohydrate biosynthetic process 7/998 97/18722 0.25931435183858 0.569575191817091 DDB1/CLTC/SLC35B4/SORBS1/FAM3C/RANBP2/GSK3B 7 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/998 114/18722 0.26264293666682 0.576149916122998 BMP7/PARP1/TGFBR3/FERMT1/TGFBR1/PPARG/CDKN1C/GPC3 8 GO:0051817 modulation of process of other organism involved in symbiotic interaction 6/998 81/18722 0.262826396711095 0.576149916122998 DAG1/ANO6/FMR1/EIF2AK4/STOM/PPIB 6 GO:0050870 positive regulation of T cell activation 14/998 216/18722 0.263305240515263 0.576149916122998 CD46/DPP4/TFRC/CD55/CD24/CD47/IL6ST/HSPD1/GLI3/DOCK8/YES1/GATA3/FLOT2/PNP 14 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 4/998 49/18722 0.264073309573326 0.576149916122998 TFRC/HSPD1/SWAP70/RIF1 4 GO:0002208 somatic diversification of immunoglobulins involved in immune response 4/998 49/18722 0.264073309573326 0.576149916122998 TFRC/HSPD1/SWAP70/RIF1 4 GO:0002762 negative regulation of myeloid leukocyte differentiation 4/998 49/18722 0.264073309573326 0.576149916122998 FBN1/CDK6/TLR3/CTNNB1 4 GO:0009066 aspartate family amino acid metabolic process 4/998 49/18722 0.264073309573326 0.576149916122998 MTR/SMS/AASDHPPT/ASS1 4 GO:0009994 oocyte differentiation 4/998 49/18722 0.264073309573326 0.576149916122998 LGR5/ZFX/CTNNB1/BCL2 4 GO:0010823 negative regulation of mitochondrion organization 4/998 49/18722 0.264073309573326 0.576149916122998 TFRC/HUWE1/PPARG/LMNA 4 GO:0014075 response to amine 4/998 49/18722 0.264073309573326 0.576149916122998 GLDC/RANBP2/ASS1/HDAC2 4 GO:0030857 negative regulation of epithelial cell differentiation 4/998 49/18722 0.264073309573326 0.576149916122998 YAP1/CCND1/TP63/CTNNB1 4 GO:0042461 photoreceptor cell development 4/998 49/18722 0.264073309573326 0.576149916122998 MYO7A/AHI1/TUG1/PRKCI 4 GO:0043330 response to exogenous dsRNA 4/998 49/18722 0.264073309573326 0.576149916122998 COLEC12/TLR3/DHX36/DDX1 4 GO:0045190 isotype switching 4/998 49/18722 0.264073309573326 0.576149916122998 TFRC/HSPD1/SWAP70/RIF1 4 GO:0070849 response to epidermal growth factor 4/998 49/18722 0.264073309573326 0.576149916122998 EGFR/TPR/GAREM1/ERRFI1 4 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 4/998 49/18722 0.264073309573326 0.576149916122998 GJA1/ADAMTS1/DNMT1/MDM2 4 GO:0002720 positive regulation of cytokine production involved in immune response 5/998 65/18722 0.264905593976955 0.5762800442307 CD55/DHX36/FZD5/DDX1/GATA3 5 GO:0003170 heart valve development 5/998 65/18722 0.264905593976955 0.5762800442307 GJA5/MDM2/HECTD1/EFNA1/GATA3 5 GO:0045453 bone resorption 5/998 65/18722 0.264905593976955 0.5762800442307 EGFR/TFRC/NF1/CTNNB1/LTBP3 5 GO:0060389 pathway-restricted SMAD protein phosphorylation 5/998 65/18722 0.264905593976955 0.5762800442307 BMP7/LRP1/TGFBR3/TGFBR1/PPARG 5 GO:0071677 positive regulation of mononuclear cell migration 5/998 65/18722 0.264905593976955 0.5762800442307 APP/ANO6/CALR/CD47/DOCK8 5 GO:0072577 endothelial cell apoptotic process 5/998 65/18722 0.264905593976955 0.5762800442307 ANO6/PRKCI/GATA3/PDCD4/NFE2L2 5 GO:0090307 mitotic spindle assembly 5/998 65/18722 0.264905593976955 0.5762800442307 TPR/GOLGA2/HSPA1B/STAG1/HNRNPU 5 GO:0048017 inositol lipid-mediated signaling 12/998 182/18722 0.26513155145931 0.576531374497734 EGFR/NF1/IGF1R/ERBB3/EXOC1/PLXNB1/EZR/NEDD4/PIK3CB/PLEKHA1/PTK2/GATA3 12 GO:0044839 cell cycle G2/M phase transition 10/998 148/18722 0.265365186117087 0.576799182646674 APP/BRD4/PBX1/FOXO4/SKP2/USP47/CCND1/WEE1/RAD21/ABCB1 10 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 2/998 19/18722 0.268989248758811 0.577464172602694 TTC37/DCP2 2 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 2/998 19/18722 0.268989248758811 0.577464172602694 DHX36/DDX1 2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/998 19/18722 0.268989248758811 0.577464172602694 MDM2/PLK2 2 GO:0007530 sex determination 2/998 19/18722 0.268989248758811 0.577464172602694 SF1/MAP3K4 2 GO:0008356 asymmetric cell division 2/998 19/18722 0.268989248758811 0.577464172602694 PARD3/GOLGA2 2 GO:0009226 nucleotide-sugar biosynthetic process 2/998 19/18722 0.268989248758811 0.577464172602694 GFPT1/UXS1 2 GO:0010002 cardioblast differentiation 2/998 19/18722 0.268989248758811 0.577464172602694 ISL1/DHX36 2 GO:0010885 regulation of cholesterol storage 2/998 19/18722 0.268989248758811 0.577464172602694 ABCA1/PPARG 2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 2/998 19/18722 0.268989248758811 0.577464172602694 ACSL3/TECR 2 GO:0035728 response to hepatocyte growth factor 2/998 19/18722 0.268989248758811 0.577464172602694 NRP1/GAB1 2 GO:0044003 modulation by symbiont of host process 2/998 19/18722 0.268989248758811 0.577464172602694 DAG1/ANO6 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/998 19/18722 0.268989248758811 0.577464172602694 MPHOSPH8/TOP2B 2 GO:0046716 muscle cell cellular homeostasis 2/998 19/18722 0.268989248758811 0.577464172602694 DMD/GAA 2 GO:0046794 transport of virus 2/998 19/18722 0.268989248758811 0.577464172602694 CTSL/FMR1 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/998 19/18722 0.268989248758811 0.577464172602694 DNMT1/CTNNB1 2 GO:0060039 pericardium development 2/998 19/18722 0.268989248758811 0.577464172602694 BMP7/SETD2 2 GO:0060216 definitive hemopoiesis 2/998 19/18722 0.268989248758811 0.577464172602694 TGFBR3/RBFOX2 2 GO:0061323 cell proliferation involved in heart morphogenesis 2/998 19/18722 0.268989248758811 0.577464172602694 ISL1/CTNNB1 2 GO:0070233 negative regulation of T cell apoptotic process 2/998 19/18722 0.268989248758811 0.577464172602694 EFNA1/DOCK8 2 GO:0070262 peptidyl-serine dephosphorylation 2/998 19/18722 0.268989248758811 0.577464172602694 SWAP70/PPP2R2B 2 GO:0070734 histone H3-K27 methylation 2/998 19/18722 0.268989248758811 0.577464172602694 SUZ12/GATA3 2 GO:0086014 atrial cardiac muscle cell action potential 2/998 19/18722 0.268989248758811 0.577464172602694 GJA1/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/998 19/18722 0.268989248758811 0.577464172602694 GJA1/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/998 19/18722 0.268989248758811 0.577464172602694 GJA1/GJA5 2 GO:0097623 potassium ion export across plasma membrane 2/998 19/18722 0.268989248758811 0.577464172602694 DLG1/ANO6 2 GO:1900221 regulation of amyloid-beta clearance 2/998 19/18722 0.268989248758811 0.577464172602694 LRPAP1/LRP1 2 GO:1903204 negative regulation of oxidative stress-induced neuron death 2/998 19/18722 0.268989248758811 0.577464172602694 CTNNB1/OXR1 2 GO:1903975 regulation of glial cell migration 2/998 19/18722 0.268989248758811 0.577464172602694 LRP1/P2RX4 2 GO:2000269 regulation of fibroblast apoptotic process 2/998 19/18722 0.268989248758811 0.577464172602694 TP63/STK17A 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/998 19/18722 0.268989248758811 0.577464172602694 AAK1/PIK3CB 2 GO:0071902 positive regulation of protein serine/threonine kinase activity 13/998 200/18722 0.270117791894332 0.578585327761539 EGFR/MAGED1/CD24/ATP2B4/DVL3/MAP3K4/CCND1/FERMT2/ERP29/PTPN1/KRAS/FZD5/MAP3K13 13 GO:0000038 very long-chain fatty acid metabolic process 3/998 34/18722 0.271173778401166 0.578585327761539 SLC27A2/HACD3/TECR 3 GO:0000096 sulfur amino acid metabolic process 3/998 34/18722 0.271173778401166 0.578585327761539 MTR/SMS/CDO1 3 GO:0002183 cytoplasmic translational initiation 3/998 34/18722 0.271173778401166 0.578585327761539 EIF3A/EIF4G1/DENR 3 GO:0019320 hexose catabolic process 3/998 34/18722 0.271173778401166 0.578585327761539 LRP5/FUT8/GLB1 3 GO:0034383 low-density lipoprotein particle clearance 3/998 34/18722 0.271173778401166 0.578585327761539 CNPY2/MYLIP/ANXA2 3 GO:0035137 hindlimb morphogenesis 3/998 34/18722 0.271173778401166 0.578585327761539 TP63/CTNNB1/GPC3 3 GO:0035308 negative regulation of protein dephosphorylation 3/998 34/18722 0.271173778401166 0.578585327761539 SWAP70/BOD1L1/GSK3B 3 GO:0048261 negative regulation of receptor-mediated endocytosis 3/998 34/18722 0.271173778401166 0.578585327761539 ITGAV/LRPAP1/ATXN2 3 GO:0048536 spleen development 3/998 34/18722 0.271173778401166 0.578585327761539 PBX1/PRKDC/BCL2 3 GO:0048741 skeletal muscle fiber development 3/998 34/18722 0.271173778401166 0.578585327761539 HOMER1/BCL2/PLEC 3 GO:0048854 brain morphogenesis 3/998 34/18722 0.271173778401166 0.578585327761539 SLC6A4/NF1/FZD6 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/998 34/18722 0.271173778401166 0.578585327761539 GJA1/GJA5/PKP2 3 GO:0098751 bone cell development 3/998 34/18722 0.271173778401166 0.578585327761539 FBN1/WASF2/ANXA2 3 GO:1904893 negative regulation of receptor signaling pathway via STAT 3/998 34/18722 0.271173778401166 0.578585327761539 LEPROT/SUZ12/PPARG 3 GO:0061013 regulation of mRNA catabolic process 11/998 166/18722 0.271857047149759 0.579806226784679 FUS/PUM1/DCP2/FMR1/MAPK14/DHX36/AGO2/TNRC6A/SECISBP2/ZC3H14/HNRNPU 11 GO:0060395 SMAD protein signal transduction 6/998 82/18722 0.27198595176046 0.579844285072013 BMP7/LRP1/PARP1/TGFBR1/PPARG/SPTBN1 6 GO:2000116 regulation of cysteine-type endopeptidase activity 15/998 235/18722 0.272623865564101 0.580967021269458 ASPH/PERP/IFI6/ARL6IP5/HSPD1/MDM2/USP47/TP63/SIAH2/DHCR24/PPARG/BCAP31/VCP/CAST/PMAIP1 15 GO:0050766 positive regulation of phagocytosis 5/998 66/18722 0.275229663874002 0.586041629317358 ANO6/LRP1/CALR/CD47/RAB31 5 GO:2000573 positive regulation of DNA biosynthetic process 5/998 66/18722 0.275229663874002 0.586041629317358 MAP3K4/PKIB/HSP90AA1/CTNNB1/TNKS2 5 GO:0008654 phospholipid biosynthetic process 16/998 253/18722 0.275915322333991 0.586367749100713 ISYNA1/PGAP1/PISD/IDH1/HEXB/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/PIK3CB/SH3YL1/PTDSS1/ACSL3/FAR1 16 GO:0038093 Fc receptor signaling pathway 4/998 50/18722 0.276056680193364 0.586367749100713 CD47/VAV3/YES1/PTK2 4 GO:0043268 positive regulation of potassium ion transport 4/998 50/18722 0.276056680193364 0.586367749100713 AKAP9/DLG1/ANO6/KCNN4 4 GO:0045058 T cell selection 4/998 50/18722 0.276056680193364 0.586367749100713 CTSL/GLI3/GATA3/BCL2 4 GO:0050873 brown fat cell differentiation 4/998 50/18722 0.276056680193364 0.586367749100713 BMP7/ADRB1/MAPK14/HNRNPU 4 GO:0070231 T cell apoptotic process 4/998 50/18722 0.276056680193364 0.586367749100713 EFNA1/GLI3/DOCK8/KDELR1 4 GO:0009914 hormone transport 19/998 306/18722 0.278692850266396 0.591572868890606 EGFR/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ISL1/SYT7/KDM5B/SLC16A1/SLC16A2/TRPV6/TCF7L2/RAB11FIP1/GATA3/SNX4/TMF1 19 GO:0070665 positive regulation of leukocyte proliferation 10/998 150/18722 0.278843844001368 0.591572868890606 CD46/TFRC/SLC39A10/CD55/CD24/IL6ST/VAV3/PTK2/BCL2/PNP 10 GO:0006997 nucleus organization 9/998 133/18722 0.278847123221563 0.591572868890606 SF1/TPR/REEP3/RTN4/SMARCA5/SUN1/PLEC/TMF1/LMNA 9 GO:0000819 sister chromatid segregation 13/998 202/18722 0.28174613899942 0.597237755467306 EML4/ATRX/TPR/SFPQ/TOP2B/RAD21/CTNNB1/WAPL/ANAPC5/PDS5A/NIPBL/STAG1/HNRNPU 13 GO:0019722 calcium-mediated signaling 13/998 202/18722 0.28174613899942 0.597237755467306 EGFR/NFAT5/NUDT4/ATP2B4/DMD/PPP1R9A/SLC9A1/P2RX4/BCAP31/ATP2A2/SPPL3/GSK3B/MCTP2 13 GO:0061640 cytoskeleton-dependent cytokinesis 7/998 100/18722 0.284366741388135 0.601435525258083 MYH10/RASA1/ANK3/SON/SPTBN1/PLEC/TTC19 7 GO:0022618 ribonucleoprotein complex assembly 14/998 220/18722 0.285556405129163 0.601435525258083 PRKDC/EIF3A/SF1/SRSF5/RBM5/DICER1/HSP90AA1/SF3B1/DDX1/AGO2/DENR/SNRNP200/PRPF8/LUC7L3 14 GO:0010517 regulation of phospholipase activity 5/998 67/18722 0.285634832387669 0.601435525258083 EGFR/LRP1/PLA2R1/FGFR2/ARL1 5 GO:0032890 regulation of organic acid transport 5/998 67/18722 0.285634832387669 0.601435525258083 ITGB1/SLC43A2/ARL6IP5/PLA2R1/P2RX4 5 GO:0007020 microtubule nucleation 3/998 35/18722 0.285908607828335 0.601435525258083 AKAP9/GOLGA2/HSPA1B 3 GO:0010664 negative regulation of striated muscle cell apoptotic process 3/998 35/18722 0.285908607828335 0.601435525258083 BMP7/PPP1R10/NFE2L2 3 GO:0010837 regulation of keratinocyte proliferation 3/998 35/18722 0.285908607828335 0.601435525258083 YAP1/TP63/FGFR2 3 GO:0032350 regulation of hormone metabolic process 3/998 35/18722 0.285908607828335 0.601435525258083 TCF7L2/GATA3/STC2 3 GO:0040001 establishment of mitotic spindle localization 3/998 35/18722 0.285908607828335 0.601435525258083 ITGB1/GJA1/GPSM2 3 GO:0042462 eye photoreceptor cell development 3/998 35/18722 0.285908607828335 0.601435525258083 MYO7A/TUG1/PRKCI 3 GO:0044273 sulfur compound catabolic process 3/998 35/18722 0.285908607828335 0.601435525258083 CDO1/GNS/GLB1 3 GO:0045880 positive regulation of smoothened signaling pathway 3/998 35/18722 0.285908607828335 0.601435525258083 DLG5/GPC3/CTNNA1 3 GO:0045907 positive regulation of vasoconstriction 3/998 35/18722 0.285908607828335 0.601435525258083 EGFR/GJA1/GJA5 3 GO:0090181 regulation of cholesterol metabolic process 3/998 35/18722 0.285908607828335 0.601435525258083 LPCAT3/ACADVL/MBTPS1 3 GO:0097502 mannosylation 3/998 35/18722 0.285908607828335 0.601435525258083 DPY19L1/TMTC3/B4GAT1 3 GO:0098810 neurotransmitter reuptake 3/998 35/18722 0.285908607828335 0.601435525258083 SLC6A4/ITGB1/SLC29A1 3 GO:1905508 protein localization to microtubule organizing center 3/998 35/18722 0.285908607828335 0.601435525258083 GOLGB1/PCM1/GSK3B 3 GO:0002705 positive regulation of leukocyte mediated immunity 9/998 134/18722 0.286098676842439 0.601435525258083 TFRC/CADM1/CD55/HSPD1/RIF1/DHX36/FZD5/DDX1/GATA3 9 GO:0010656 negative regulation of muscle cell apoptotic process 4/998 51/18722 0.288126295513438 0.601435525258083 BMP7/DNMT1/PPP1R10/NFE2L2 4 GO:0014009 glial cell proliferation 4/998 51/18722 0.288126295513438 0.601435525258083 EGFR/UFL1/PRKCI/DICER1 4 GO:0021872 forebrain generation of neurons 4/998 51/18722 0.288126295513438 0.601435525258083 NRP2/NRP1/GLI3/FGFR2 4 GO:0032873 negative regulation of stress-activated MAPK cascade 4/998 51/18722 0.288126295513438 0.601435525258083 DLG1/MARVELD3/EZR/PDCD4 4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4/998 51/18722 0.288126295513438 0.601435525258083 ASH1L/USP10/TLE1/OTUD7B 4 GO:0045668 negative regulation of osteoblast differentiation 4/998 51/18722 0.288126295513438 0.601435525258083 CRIM1/CDK6/LRP5/PPARG 4 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 4/998 51/18722 0.288126295513438 0.601435525258083 DLG1/MARVELD3/EZR/PDCD4 4 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 17/998 273/18722 0.288862929658003 0.601435525258083 CDH1/TENM3/DSC2/DSC3/ITGB1/CLDN4/CADM1/DSG2/PCDH11X/OBSL1/FAT1/BSG/CLSTN1/MAPK14/PTPRM/CLDN7/CD164 17 GO:0000272 polysaccharide catabolic process 2/998 20/18722 0.289140618348552 0.601435525258083 AGL/GAA 2 GO:0006883 cellular sodium ion homeostasis 2/998 20/18722 0.289140618348552 0.601435525258083 SLC9A1/SLC1A3 2 GO:0010042 response to manganese ion 2/998 20/18722 0.289140618348552 0.601435525258083 APP/HSPA5 2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 2/998 20/18722 0.289140618348552 0.601435525258083 EIF4G1/PARD3 2 GO:0032211 negative regulation of telomere maintenance via telomerase 2/998 20/18722 0.289140618348552 0.601435525258083 DCP2/HNRNPU 2 GO:0039535 regulation of RIG-I signaling pathway 2/998 20/18722 0.289140618348552 0.601435525258083 PUM1/ANKRD17 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/998 20/18722 0.289140618348552 0.601435525258083 MPHOSPH8/TOP2B 2 GO:0045844 positive regulation of striated muscle tissue development 2/998 20/18722 0.289140618348552 0.601435525258083 CTNNB1/BCL2 2 GO:0046485 ether lipid metabolic process 2/998 20/18722 0.289140618348552 0.601435525258083 FASN/FAR1 2 GO:0046931 pore complex assembly 2/998 20/18722 0.289140618348552 0.601435525258083 ANO6/RTN4 2 GO:0048636 positive regulation of muscle organ development 2/998 20/18722 0.289140618348552 0.601435525258083 CTNNB1/BCL2 2 GO:0060044 negative regulation of cardiac muscle cell proliferation 2/998 20/18722 0.289140618348552 0.601435525258083 GJA1/VGLL4 2 GO:0060231 mesenchymal to epithelial transition 2/998 20/18722 0.289140618348552 0.601435525258083 CTNNB1/GATA3 2 GO:0070932 histone H3 deacetylation 2/998 20/18722 0.289140618348552 0.601435525258083 SFPQ/HDAC2 2 GO:0071397 cellular response to cholesterol 2/998 20/18722 0.289140618348552 0.601435525258083 DAG1/ABCA1 2 GO:0071625 vocalization behavior 2/998 20/18722 0.289140618348552 0.601435525258083 GLI3/SHANK2 2 GO:1901679 nucleotide transmembrane transport 2/998 20/18722 0.289140618348552 0.601435525258083 SLC19A1/SLC25A36 2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/998 20/18722 0.289140618348552 0.601435525258083 MET/NFE2L2 2 GO:2000010 positive regulation of protein localization to cell surface 2/998 20/18722 0.289140618348552 0.601435525258083 TM9SF4/GPD1L 2 GO:2000479 regulation of cAMP-dependent protein kinase activity 2/998 20/18722 0.289140618348552 0.601435525258083 ATP2B4/PKIB 2 GO:2000757 negative regulation of peptidyl-lysine acetylation 2/998 20/18722 0.289140618348552 0.601435525258083 ZNF451/HDAC2 2 GO:0010660 regulation of muscle cell apoptotic process 6/998 84/18722 0.290525364651115 0.603834764666987 BMP7/DNMT1/PPARG/PDCD4/PPP1R10/NFE2L2 6 GO:0097061 dendritic spine organization 6/998 84/18722 0.290525364651115 0.603834764666987 IGF1R/PPP1R9A/EFNA1/HOMER1/DHX36/VPS35 6 GO:0031214 biomineral tissue development 11/998 169/18722 0.291178004909939 0.604950403356462 FBN2/ATP2B1/BMP7/LGR4/ANO6/TFAP2A/ANKH/FGFR2/LTBP3/GPC3/ATRAID 11 GO:0051092 positive regulation of NF-kappaB transcription factor activity 10/998 152/18722 0.292518283788937 0.607493221822608 APP/TFRC/TLR3/RPS6KA5/ERC1/PRKCI/KRAS/HSPA1B/FLOT2/MAP3K13 10 GO:0051963 regulation of synapse assembly 7/998 101/18722 0.292845669569143 0.607931308477334 APP/DLG5/PPP1R9A/EIF4G1/TPBG/CLSTN1/VPS35 7 GO:0051101 regulation of DNA binding 8/998 118/18722 0.293618717287118 0.609293848551686 PARP1/ISL1/MSX2/NSD1/PPARG/CTNNB1/GATA3/HDAC2 8 GO:0072593 reactive oxygen species metabolic process 15/998 239/18722 0.294256879547883 0.610133108863979 EGFR/BMP7/IFI6/SLC5A3/TFAP2A/HSPD1/PRDX4/PLA2R1/MAPK14/BCL2/STK17A/SOD3/PMAIP1/NFE2L2/PAGE4 15 GO:1903039 positive regulation of leukocyte cell-cell adhesion 15/998 239/18722 0.294256879547883 0.610133108863979 CD46/DPP4/TFRC/NFAT5/CD55/CD24/CD47/IL6ST/HSPD1/GLI3/DOCK8/YES1/GATA3/FLOT2/PNP 15 GO:0009988 cell-cell recognition 5/998 68/18722 0.296111616586402 0.613248215072433 DLG1/SPESP1/FOLR1/B4GALT1/DOCK8 5 GO:0042698 ovulation cycle 5/998 68/18722 0.296111616586402 0.613248215072433 EGFR/SERPINF1/HSPA5/ADAMTS1/PLEKHA1 5 GO:1901016 regulation of potassium ion transmembrane transporter activity 5/998 68/18722 0.296111616586402 0.613248215072433 AKAP9/ITGB1/DLG1/ANK3/NEDD4 5 GO:0000302 response to reactive oxygen species 14/998 222/18722 0.296899206658641 0.614635510691818 EGFR/MET/BMP7/NET1/HSPD1/MDM2/STK26/PAWR/TRA2B/PLEKHA1/BCL2/SOD3/HDAC2/NFE2L2 14 GO:0043487 regulation of RNA stability 11/998 170/18722 0.297703543769676 0.616056362275656 LIN28B/FUS/PUM1/DCP2/FMR1/MAPK14/DHX36/AGO2/TNRC6A/ZC3H14/HNRNPU 11 GO:0045069 regulation of viral genome replication 6/998 85/18722 0.299891879387308 0.618344772399169 DDB1/HACD3/MPHOSPH8/TOP2B/PKN2/BCL2 6 GO:0055013 cardiac muscle cell development 6/998 85/18722 0.299891879387308 0.618344772399169 ISL1/OBSL1/PLEC/YY1/LMNA/HNRNPU 6 GO:2000779 regulation of double-strand break repair 6/998 85/18722 0.299891879387308 0.618344772399169 PARP1/FUS/PRKDC/SETD2/RIF1/UBR5 6 GO:0002218 activation of innate immune response 4/998 52/18722 0.300267544074776 0.618344772399169 PRKDC/SFPQ/HSP90AA1/HEXIM1 4 GO:0035176 social behavior 4/998 52/18722 0.300267544074776 0.618344772399169 SLC6A4/VPS13A/PCM1/SHANK2 4 GO:0045010 actin nucleation 4/998 52/18722 0.300267544074776 0.618344772399169 IQGAP2/SCIN/WASF2/NCKAP1 4 GO:0051496 positive regulation of stress fiber assembly 4/998 52/18722 0.300267544074776 0.618344772399169 NRP1/CD47/FERMT2/TGFBR1 4 GO:0072132 mesenchyme morphogenesis 4/998 52/18722 0.300267544074776 0.618344772399169 BMP7/MDM2/ISL1/TGFBR1 4 GO:2000378 negative regulation of reactive oxygen species metabolic process 4/998 52/18722 0.300267544074776 0.618344772399169 TFAP2A/HSPD1/BCL2/PAGE4 4 GO:0003230 cardiac atrium development 3/998 36/18722 0.30070434344407 0.618344772399169 GJA5/MDM2/ISL1 3 GO:0030224 monocyte differentiation 3/998 36/18722 0.30070434344407 0.618344772399169 CDK6/PPARG/FASN 3 GO:0036314 response to sterol 3/998 36/18722 0.30070434344407 0.618344772399169 DAG1/ABCA1/TGFBR1 3 GO:0051955 regulation of amino acid transport 3/998 36/18722 0.30070434344407 0.618344772399169 ITGB1/SLC43A2/ARL6IP5 3 GO:0070873 regulation of glycogen metabolic process 3/998 36/18722 0.30070434344407 0.618344772399169 SORBS1/GSK3B/PHLDA2 3 GO:0090322 regulation of superoxide metabolic process 3/998 36/18722 0.30070434344407 0.618344772399169 EGFR/BMP7/NFE2L2 3 GO:1901658 glycosyl compound catabolic process 3/998 36/18722 0.30070434344407 0.618344772399169 FUCA1/GUSB/PNP 3 GO:1902749 regulation of cell cycle G2/M phase transition 7/998 102/18722 0.30138036519403 0.619490900266942 APP/BRD4/PBX1/FOXO4/USP47/CCND1/RAD21 7 GO:0010906 regulation of glucose metabolic process 8/998 119/18722 0.30149946303823 0.619491812877842 DDB1/SLC35B4/SORBS1/FAM3C/RANBP2/GSK3B/PMAIP1/PHLDA2 8 GO:0045165 cell fate commitment 16/998 258/18722 0.302162656106775 0.620610238998218 CTSL/NRP1/ITGB1/LMO4/NR2F2/PRKDC/ISL1/GLI3/ESRP1/TGFBR1/PPARG/FGFR2/CTNNB1/TCF7L2/GATA3/BCL2 16 GO:0110148 biomineralization 11/998 171/18722 0.304268060166871 0.62468877000835 FBN2/ATP2B1/BMP7/LGR4/ANO6/TFAP2A/ANKH/FGFR2/LTBP3/GPC3/ATRAID 11 GO:0016052 carbohydrate catabolic process 10/998 154/18722 0.306367909343744 0.624972462183034 APP/AGL/LRP5/FUT8/HEXB/MANBA/GM2A/GAA/GUSB/GLB1 10 GO:0019226 transmission of nerve impulse 5/998 69/18722 0.306650637230348 0.624972462183034 ANK3/FMR1/P2RX4/JAM3/PLEC 5 GO:0050671 positive regulation of lymphocyte proliferation 9/998 137/18722 0.308141337391121 0.624972462183034 CD46/TFRC/SLC39A10/CD55/CD24/IL6ST/VAV3/BCL2/PNP 9 GO:0060078 regulation of postsynaptic membrane potential 9/998 137/18722 0.308141337391121 0.624972462183034 APP/ADRB1/GABRE/PPP1R9A/S1PR2/P2RX4/GABRA4/GSK3B/SLC29A1 9 GO:0000002 mitochondrial genome maintenance 2/998 21/18722 0.309222914638616 0.624972462183034 PARP1/SLC25A36 2 GO:0006067 ethanol metabolic process 2/998 21/18722 0.309222914638616 0.624972462183034 ACSS1/ADH5 2 GO:0006925 inflammatory cell apoptotic process 2/998 21/18722 0.309222914638616 0.624972462183034 CTSL/PIK3CB 2 GO:0008090 retrograde axonal transport 2/998 21/18722 0.309222914638616 0.624972462183034 DST/DYNC1H1 2 GO:0009067 aspartate family amino acid biosynthetic process 2/998 21/18722 0.309222914638616 0.624972462183034 MTR/AASDHPPT 2 GO:0010878 cholesterol storage 2/998 21/18722 0.309222914638616 0.624972462183034 ABCA1/PPARG 2 GO:0019985 translesion synthesis 2/998 21/18722 0.309222914638616 0.624972462183034 USP10/VCP 2 GO:0032303 regulation of icosanoid secretion 2/998 21/18722 0.309222914638616 0.624972462183034 PLA2R1/P2RX4 2 GO:0033762 response to glucagon 2/998 21/18722 0.309222914638616 0.624972462183034 CDO1/ASS1 2 GO:0033962 P-body assembly 2/998 21/18722 0.309222914638616 0.624972462183034 DYNC1H1/ATXN2 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/998 21/18722 0.309222914638616 0.624972462183034 SLC26A2/TPST2 2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 2/998 21/18722 0.309222914638616 0.624972462183034 WASF2/NCKAP1 2 GO:0035020 regulation of Rac protein signal transduction 2/998 21/18722 0.309222914638616 0.624972462183034 PIK3CB/KRAS 2 GO:0035455 response to interferon-alpha 2/998 21/18722 0.309222914638616 0.624972462183034 TPR/GATA3 2 GO:0044241 lipid digestion 2/998 21/18722 0.309222914638616 0.624972462183034 LIMA1/LPCAT3 2 GO:0044766 multi-organism transport 2/998 21/18722 0.309222914638616 0.624972462183034 CTSL/FMR1 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/998 21/18722 0.309222914638616 0.624972462183034 FERMT1/TPR 2 GO:0048199 vesicle targeting, to, from or within Golgi 2/998 21/18722 0.309222914638616 0.624972462183034 TMED9/TFG 2 GO:0048714 positive regulation of oligodendrocyte differentiation 2/998 21/18722 0.309222914638616 0.624972462183034 DAG1/HDAC2 2 GO:0048745 smooth muscle tissue development 2/998 21/18722 0.309222914638616 0.624972462183034 DLG1/NF1 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/998 21/18722 0.309222914638616 0.624972462183034 SLC26A2/TPST2 2 GO:0050849 negative regulation of calcium-mediated signaling 2/998 21/18722 0.309222914638616 0.624972462183034 ATP2B4/GSK3B 2 GO:0060117 auditory receptor cell development 2/998 21/18722 0.309222914638616 0.624972462183034 MYO7A/TRIOBP 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/998 21/18722 0.309222914638616 0.624972462183034 DHX36/DDX1 2 GO:0072170 metanephric tubule development 2/998 21/18722 0.309222914638616 0.624972462183034 LGR4/YAP1 2 GO:0072243 metanephric nephron epithelium development 2/998 21/18722 0.309222914638616 0.624972462183034 LGR4/YAP1 2 GO:0098856 intestinal lipid absorption 2/998 21/18722 0.309222914638616 0.624972462183034 LIMA1/LPCAT3 2 GO:1901863 positive regulation of muscle tissue development 2/998 21/18722 0.309222914638616 0.624972462183034 CTNNB1/BCL2 2 GO:1902473 regulation of protein localization to synapse 2/998 21/18722 0.309222914638616 0.624972462183034 DAG1/DLG1 2 GO:1902579 multi-organism localization 2/998 21/18722 0.309222914638616 0.624972462183034 CTSL/FMR1 2 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 2/998 21/18722 0.309222914638616 0.624972462183034 HSPD1/PAGE4 2 GO:1903429 regulation of cell maturation 2/998 21/18722 0.309222914638616 0.624972462183034 BCL2/MAP3K13 2 GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 2/998 21/18722 0.309222914638616 0.624972462183034 SLC22A5/ABCB1 2 GO:2001014 regulation of skeletal muscle cell differentiation 2/998 21/18722 0.309222914638616 0.624972462183034 DDX17/GPC1 2 GO:0022406 membrane docking 6/998 86/18722 0.30931408586113 0.624972462183034 CLN3/EZR/AHCYL1/USO1/ESYT2/ATP2A2 6 GO:0034103 regulation of tissue remodeling 6/998 86/18722 0.30931408586113 0.624972462183034 EGFR/TFRC/NF1/SUCO/SYT7/LTBP3 6 GO:2000117 negative regulation of cysteine-type endopeptidase activity 6/998 86/18722 0.30931408586113 0.624972462183034 IFI6/MDM2/USP47/SIAH2/DHCR24/CAST 6 GO:0046879 hormone secretion 18/998 295/18722 0.310994702780865 0.628125084417369 EGFR/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ISL1/SYT7/KDM5B/SLC16A1/TRPV6/TCF7L2/RAB11FIP1/GATA3/SNX4/TMF1 18 GO:0001541 ovarian follicle development 4/998 53/18722 0.312466152447536 0.630365448967768 ZFX/MMP14/BCL2/CTNNA1 4 GO:0031279 regulation of cyclase activity 4/998 53/18722 0.312466152447536 0.630365448967768 AKAP9/NF1/MAPK14/GNAS 4 GO:0034381 plasma lipoprotein particle clearance 4/998 53/18722 0.312466152447536 0.630365448967768 LRPAP1/CNPY2/MYLIP/ANXA2 4 GO:0051091 positive regulation of DNA-binding transcription factor activity 16/998 260/18722 0.312865026683467 0.630926343883501 APP/TFRC/LRP5/PLPP3/TLR3/RPS6KA5/ERC1/PRKCI/PPARG/KRAS/ARID5B/CTNNB1/HSPA1B/FLOT2/ANXA3/MAP3K13 16 GO:0007519 skeletal muscle tissue development 10/998 155/18722 0.313351914870945 0.631664226849886 NR2F2/DMD/DDX17/KLF5/HOMER1/MAPK14/CTNNB1/BCL2/PLEC/GPC1 10 GO:0002369 T cell cytokine production 3/998 37/18722 0.315536222793831 0.633210612532872 CD55/FZD5/GATA3 3 GO:0002724 regulation of T cell cytokine production 3/998 37/18722 0.315536222793831 0.633210612532872 CD55/FZD5/GATA3 3 GO:0014904 myotube cell development 3/998 37/18722 0.315536222793831 0.633210612532872 HOMER1/BCL2/PLEC 3 GO:0031646 positive regulation of nervous system process 3/998 37/18722 0.315536222793831 0.633210612532872 DAG1/DICER1/PARD3 3 GO:0032885 regulation of polysaccharide biosynthetic process 3/998 37/18722 0.315536222793831 0.633210612532872 CLTC/SORBS1/GSK3B 3 GO:0034260 negative regulation of GTPase activity 3/998 37/18722 0.315536222793831 0.633210612532872 AMOT/RDX/ARFGEF1 3 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 3/998 37/18722 0.315536222793831 0.633210612532872 CTNNB1/GATA3/GPC1 3 GO:0042401 cellular biogenic amine biosynthetic process 3/998 37/18722 0.315536222793831 0.633210612532872 SMS/AZIN1/GATA3 3 GO:0060428 lung epithelium development 3/998 37/18722 0.315536222793831 0.633210612532872 YAP1/ERRFI1/FGFR2 3 GO:0071542 dopaminergic neuron differentiation 3/998 37/18722 0.315536222793831 0.633210612532872 RYK/CTNNB1/GSK3B 3 GO:1902745 positive regulation of lamellipodium organization 3/998 37/18722 0.315536222793831 0.633210612532872 WASF2/NCKAP1/OCLN 3 GO:0032946 positive regulation of mononuclear cell proliferation 9/998 138/18722 0.315574413677558 0.633210612532872 CD46/TFRC/SLC39A10/CD55/CD24/IL6ST/VAV3/BCL2/PNP 9 GO:0010469 regulation of signaling receptor activity 11/998 173/18722 0.317505215377982 0.636840080479618 APP/NRP1/AKAP9/NCOA3/ITGB1/LRPAP1/HOMER1/PPARG/ERRFI1/HDAC2/PHLDA2 11 GO:0045860 positive regulation of protein kinase activity 23/998 386/18722 0.320380736972839 0.642360916948999 EGFR/DAG1/MAGED1/DLG1/CD24/PRLR/ATP2B4/DVL3/ERBB3/PPP1R9A/EFNA1/MAP3K4/TLR3/CCND1/FERMT2/ERP29/PTPN1/HSP90AA1/KRAS/FZD5/NEDD9/PTK2/MAP3K13 23 GO:0001659 temperature homeostasis 11/998 174/18722 0.324173425323081 0.649292064233366 ADRB1/GJA1/LGR4/IGF1R/PRLR/DYNC1H1/ESRRG/ACADVL/CPT2/NRDC/GNAS 11 GO:0050900 leukocyte migration 22/998 369/18722 0.324378525250407 0.649292064233366 APP/CSF3R/DPP4/ITGB1/ANO6/CALR/CD47/VAV3/B4GALT1/DOCK8/BSG/YES1/P2RX4/SWAP70/MIA3/JAM3/MMP14/PTK2/EPS8/GATA3/PLEC/PPIB 22 GO:0051703 biological process involved in intraspecies interaction between organisms 4/998 54/18722 0.324708212931109 0.649292064233366 SLC6A4/VPS13A/PCM1/SHANK2 4 GO:0060350 endochondral bone morphogenesis 4/998 54/18722 0.324708212931109 0.649292064233366 TRIP11/SERPINH1/MMP14/EXT2 4 GO:0072698 protein localization to microtubule cytoskeleton 4/998 54/18722 0.324708212931109 0.649292064233366 GOLGB1/PCM1/GSK3B/HNRNPU 4 GO:1902743 regulation of lamellipodium organization 4/998 54/18722 0.324708212931109 0.649292064233366 KANK1/WASF2/NCKAP1/OCLN 4 GO:2000179 positive regulation of neural precursor cell proliferation 4/998 54/18722 0.324708212931109 0.649292064233366 LRP2/ADGRG1/GLI3/CTNNB1 4 GO:0032872 regulation of stress-activated MAPK cascade 12/998 192/18722 0.327217917779136 0.65165001091598 EGFR/APP/DLG1/IGF1R/ARL6IP5/MAP3K4/TLR3/MARVELD3/EZR/PDCD4/EMC10/PAGE4 12 GO:0062207 regulation of pattern recognition receptor signaling pathway 7/998 105/18722 0.327269382102787 0.65165001091598 LGR4/TLR3/PUM1/RTN4/ANKRD17/HSPA1B/OTUD4 7 GO:2000377 regulation of reactive oxygen species metabolic process 10/998 157/18722 0.327425224717822 0.65165001091598 EGFR/BMP7/SLC5A3/TFAP2A/HSPD1/MAPK14/BCL2/STK17A/NFE2L2/PAGE4 10 GO:0071230 cellular response to amino acid stimulus 5/998 71/18722 0.327878502535218 0.65165001091598 SLC38A9/DNMT1/DNMT3A/ASS1/COL5A2 5 GO:0031110 regulation of microtubule polymerization or depolymerization 6/998 88/18722 0.328299308900433 0.65165001091598 MET/CLIP1/AKAP9/CAMSAP2/OCLN/HSPA1B 6 GO:0050779 RNA destabilization 6/998 88/18722 0.328299308900433 0.65165001091598 LIN28B/PUM1/DCP2/DHX36/AGO2/TNRC6A 6 GO:0006662 glycerol ether metabolic process 2/998 22/18722 0.329186280694246 0.65165001091598 FASN/FAR1 2 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 2/998 22/18722 0.329186280694246 0.65165001091598 SPESP1/FOLR1 2 GO:0007398 ectoderm development 2/998 22/18722 0.329186280694246 0.65165001091598 ITGA6/CTNNB1 2 GO:0016137 glycoside metabolic process 2/998 22/18722 0.329186280694246 0.65165001091598 FUCA1/GUSB 2 GO:0021854 hypothalamus development 2/998 22/18722 0.329186280694246 0.65165001091598 NRP2/NRP1 2 GO:0031281 positive regulation of cyclase activity 2/998 22/18722 0.329186280694246 0.65165001091598 NF1/MAPK14 2 GO:0035357 peroxisome proliferator activated receptor signaling pathway 2/998 22/18722 0.329186280694246 0.65165001091598 ACTN4/PPARG 2 GO:0044346 fibroblast apoptotic process 2/998 22/18722 0.329186280694246 0.65165001091598 TP63/STK17A 2 GO:0045061 thymic T cell selection 2/998 22/18722 0.329186280694246 0.65165001091598 GLI3/GATA3 2 GO:0045540 regulation of cholesterol biosynthetic process 2/998 22/18722 0.329186280694246 0.65165001091598 LPCAT3/MBTPS1 2 GO:0048169 regulation of long-term neuronal synaptic plasticity 2/998 22/18722 0.329186280694246 0.65165001091598 APP/KRAS 2 GO:0050860 negative regulation of T cell receptor signaling pathway 2/998 22/18722 0.329186280694246 0.65165001091598 PAWR/EZR 2 GO:0051412 response to corticosterone 2/998 22/18722 0.329186280694246 0.65165001091598 ATP2B1/CCND1 2 GO:0071359 cellular response to dsRNA 2/998 22/18722 0.329186280694246 0.65165001091598 COLEC12/TLR3 2 GO:0097164 ammonium ion metabolic process 2/998 22/18722 0.329186280694246 0.65165001091598 ALDH7A1/SLC44A1 2 GO:0099563 modification of synaptic structure 2/998 22/18722 0.329186280694246 0.65165001091598 MYH10/CLN3 2 GO:0106118 regulation of sterol biosynthetic process 2/998 22/18722 0.329186280694246 0.65165001091598 LPCAT3/MBTPS1 2 GO:1901032 negative regulation of response to reactive oxygen species 2/998 22/18722 0.329186280694246 0.65165001091598 MET/NFE2L2 2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 2/998 22/18722 0.329186280694246 0.65165001091598 CHD6/NFE2L2 2 GO:2000193 positive regulation of fatty acid transport 2/998 22/18722 0.329186280694246 0.65165001091598 PLA2R1/P2RX4 2 GO:0031396 regulation of protein ubiquitination 13/998 210/18722 0.329672970000937 0.65165001091598 HSPA5/SKP2/PTTG1IP/TRIM44/HUWE1/UFL1/SIAH2/NDFIP2/MYCBP2/TGFBR1/HSP90AA1/UBR5/HSPA1B 13 GO:0000578 embryonic axis specification 3/998 38/18722 0.330380689311358 0.65165001091598 COBL/CTNNB1/FZD5 3 GO:0006882 cellular zinc ion homeostasis 3/998 38/18722 0.330380689311358 0.65165001091598 SLC39A10/SLC39A7/SLC30A7 3 GO:0009309 amine biosynthetic process 3/998 38/18722 0.330380689311358 0.65165001091598 SMS/AZIN1/GATA3 3 GO:0010613 positive regulation of cardiac muscle hypertrophy 3/998 38/18722 0.330380689311358 0.65165001091598 PARP1/IL6ST/SLC9A1 3 GO:0010742 macrophage derived foam cell differentiation 3/998 38/18722 0.330380689311358 0.65165001091598 ITGAV/ABCA1/PPARG 3 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 3/998 38/18722 0.330380689311358 0.65165001091598 CALR/ISL1/TP63 3 GO:0035337 fatty-acyl-CoA metabolic process 3/998 38/18722 0.330380689311358 0.65165001091598 ACSL3/FAR1/TECR 3 GO:0090077 foam cell differentiation 3/998 38/18722 0.330380689311358 0.65165001091598 ITGAV/ABCA1/PPARG 3 GO:2000279 negative regulation of DNA biosynthetic process 3/998 38/18722 0.330380689311358 0.65165001091598 GJA1/DCP2/HNRNPU 3 GO:0022900 electron transport chain 11/998 175/18722 0.330871759659038 0.652372151502959 GLDC/DEGS1/ASPH/CYB5A/ADH5/PLEC/PDIA5/ETFA/UQCRC1/NDUFB9/COX6A1 11 GO:0043488 regulation of mRNA stability 10/998 158/18722 0.334509280288125 0.659295187763043 FUS/PUM1/DCP2/FMR1/MAPK14/DHX36/AGO2/TNRC6A/ZC3H14/HNRNPU 10 GO:0046474 glycerophospholipid biosynthetic process 13/998 211/18722 0.335795766373288 0.661440011993795 PGAP1/PISD/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/PIK3CB/SH3YL1/PTDSS1/ACSL3/FAR1 13 GO:0006906 vesicle fusion 7/998 106/18722 0.335977573608034 0.661440011993795 EEA1/VAV3/SYT7/CLN3/UVRAG/USO1/ANXA2 7 GO:0071887 leukocyte apoptotic process 7/998 106/18722 0.335977573608034 0.661440011993795 CTSL/SLC39A10/EFNA1/GLI3/DOCK8/PIK3CB/KDELR1 7 GO:0003179 heart valve morphogenesis 4/998 55/18722 0.336980207743749 0.662867146284257 GJA5/MDM2/EFNA1/GATA3 4 GO:0051898 negative regulation of protein kinase B signaling 4/998 55/18722 0.336980207743749 0.662867146284257 DAG1/DLG1/PIK3CB/PLEKHA1 4 GO:0015980 energy derivation by oxidation of organic compounds 19/998 318/18722 0.337083369734668 0.662867146284257 AGL/IL10RB/IDH1/IL6ST/OPN3/GFPT1/PHKB/UGP2/ACADVL/SORBS1/VCP/GAA/PLEC/ACO1/GSK3B/PHLDA2/UQCRC1/NDUFB9/COX6A1 19 GO:0071695 anatomical structure maturation 14/998 229/18722 0.337544814154207 0.663331833839076 APP/DAG1/RERE/TFCP2L1/FERMT1/PLXNB1/NRCAM/ANKRD17/PPARG/CTNNB1/FZD5/GATA3/BCL2/MAP3K13 14 GO:1903037 regulation of leukocyte cell-cell adhesion 20/998 336/18722 0.337573775619694 0.663331833839076 CD46/DPP4/TFRC/NFAT5/DLG5/DLG1/CD55/CD24/CD47/IL6ST/HSPD1/GLI3/DOCK8/PAWR/YES1/MIA3/GATA3/ASS1/FLOT2/PNP 20 GO:0010657 muscle cell apoptotic process 6/998 89/18722 0.337849347793092 0.663623568407726 BMP7/DNMT1/PPARG/PDCD4/PPP1R10/NFE2L2 6 GO:0006631 fatty acid metabolic process 23/998 390/18722 0.338315071388627 0.664248684450026 ACSS1/DEGS1/SLC27A2/HACD3/HADHA/CROT/ECHDC2/ACADVL/ATP6V1B1/ECI2/PPARG/CPT2/MAPK14/ACSF2/CYP2J2/ADH5/ECHDC1/ACSL3/FASN/QKI/LYPLA1/ETFA/TECR 23 GO:0030032 lamellipodium assembly 5/998 72/18722 0.33854927204013 0.664248684450026 ITGB1/VAV3/WASF2/NCKAP1/OCLN 5 GO:0070227 lymphocyte apoptotic process 5/998 72/18722 0.33854927204013 0.664248684450026 SLC39A10/EFNA1/GLI3/DOCK8/KDELR1 5 GO:0097237 cellular response to toxic substance 8/998 124/18722 0.341529524816499 0.669844346005613 BMP7/MGST3/PPP1R9A/PRDX4/GPX8/ADH5/SOD3/NFE2L2 8 GO:0023061 signal release 27/998 463/18722 0.342264522565617 0.671033823625642 EGFR/WLS/SLC6A4/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ABCA1/PPP1R9A/ISL1/SYT7/KDM5B/SLC16A1/TRPV6/FMR1/P2RX4/TCF7L2/RAB11FIP1/GATA3/ATP2A2/GSK3B/MCTP2/SNX4/TMF1 27 GO:0032103 positive regulation of response to external stimulus 25/998 427/18722 0.342676517258514 0.671589375603116 EGFR/APP/MET/NRP1/CADM1/TGM2/ANO6/LRP1/CALR/CD47/PRKDC/IL6ST/HSPD1/TLR3/PUM1/SFPQ/ANKRD17/TPBG/P2RX4/SWAP70/HSP90AA1/PTK2/PDCD4/SNX4/HEXIM1 25 GO:0051302 regulation of cell division 11/998 177/18722 0.344349888377256 0.674383729683534 NCOA3/TP63/BIRC6/SETD2/GAREM1/UVRAG/PKN2/FGFR2/RAB11FIP4/PLK2/PRPF40A 11 GO:0008637 apoptotic mitochondrial changes 7/998 107/18722 0.344716872479799 0.674383729683534 IFI6/HSPD1/BCL2/GSK3B/PMAIP1/LMNA/VPS35 7 GO:0014742 positive regulation of muscle hypertrophy 3/998 39/18722 0.345215401115699 0.674383729683534 PARP1/IL6ST/SLC9A1 3 GO:0016572 histone phosphorylation 3/998 39/18722 0.345215401115699 0.674383729683534 RPS6KA5/FMR1/BAZ1B 3 GO:0017158 regulation of calcium ion-dependent exocytosis 3/998 39/18722 0.345215401115699 0.674383729683534 SYT7/TRPV6/ATP2A2 3 GO:0034314 Arp2/3 complex-mediated actin nucleation 3/998 39/18722 0.345215401115699 0.674383729683534 IQGAP2/WASF2/NCKAP1 3 GO:1902742 apoptotic process involved in development 3/998 39/18722 0.345215401115699 0.674383729683534 BMP7/LRP5/FZD5 3 GO:0050729 positive regulation of inflammatory response 9/998 142/18722 0.34565023183135 0.674383729683534 EGFR/APP/TGM2/CD47/IL6ST/HSPD1/TLR3/PDCD4/SNX4 9 GO:0006520 cellular amino acid metabolic process 17/998 284/18722 0.34624414699085 0.674383729683534 GLDC/IARS2/RIMKLB/ATP2B4/MTR/GFPT1/SLC16A2/CLN3/SLC1A3/SMS/CDO1/AASDHPPT/ALDH18A1/AZIN1/ASS1/SERINC3/BCAT1 17 GO:0070302 regulation of stress-activated protein kinase signaling cascade 12/998 195/18722 0.346467345088772 0.674383729683534 EGFR/APP/DLG1/IGF1R/ARL6IP5/MAP3K4/TLR3/MARVELD3/EZR/PDCD4/EMC10/PAGE4 12 GO:0045638 negative regulation of myeloid cell differentiation 6/998 90/18722 0.347429144143513 0.674383729683534 FBN1/CDK6/TLR3/CTNNB1/MEIS2/HSPA9 6 GO:0048477 oogenesis 6/998 90/18722 0.347429144143513 0.674383729683534 LGR5/DIAPH2/ZFX/HEXB/CTNNB1/BCL2 6 GO:0097581 lamellipodium organization 6/998 90/18722 0.347429144143513 0.674383729683534 KANK1/ITGB1/VAV3/WASF2/NCKAP1/OCLN 6 GO:0001919 regulation of receptor recycling 2/998 23/18722 0.348986360954689 0.674383729683534 NSG1/ANXA2 2 GO:0002052 positive regulation of neuroblast proliferation 2/998 23/18722 0.348986360954689 0.674383729683534 GLI3/CTNNB1 2 GO:0002363 alpha-beta T cell lineage commitment 2/998 23/18722 0.348986360954689 0.674383729683534 CTSL/BCL2 2 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 2/998 23/18722 0.348986360954689 0.674383729683534 MME/ENPEP 2 GO:0003323 type B pancreatic cell development 2/998 23/18722 0.348986360954689 0.674383729683534 CDK6/GSK3B 2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 2/998 23/18722 0.348986360954689 0.674383729683534 CLDN4/CLDN7 2 GO:0030194 positive regulation of blood coagulation 2/998 23/18722 0.348986360954689 0.674383729683534 ANO6/NFE2L2 2 GO:0035162 embryonic hemopoiesis 2/998 23/18722 0.348986360954689 0.674383729683534 PBX1/GATA3 2 GO:0035988 chondrocyte proliferation 2/998 23/18722 0.348986360954689 0.674383729683534 GOLGB1/MMP14 2 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 2/998 23/18722 0.348986360954689 0.674383729683534 CTSL/BCL2 2 GO:0046618 xenobiotic export 2/998 23/18722 0.348986360954689 0.674383729683534 SLC22A5/ABCB1 2 GO:0051131 chaperone-mediated protein complex assembly 2/998 23/18722 0.348986360954689 0.674383729683534 HSPD1/HSP90AA1 2 GO:0051457 maintenance of protein location in nucleus 2/998 23/18722 0.348986360954689 0.674383729683534 SUN1/HNRNPU 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/998 23/18722 0.348986360954689 0.674383729683534 AKAP9/GJA5 2 GO:0060384 innervation 2/998 23/18722 0.348986360954689 0.674383729683534 NRP1/ISL1 2 GO:0071218 cellular response to misfolded protein 2/998 23/18722 0.348986360954689 0.674383729683534 DNAJB14/VCP 2 GO:0071305 cellular response to vitamin D 2/998 23/18722 0.348986360954689 0.674383729683534 ATP2B1/TRIM24 2 GO:0071636 positive regulation of transforming growth factor beta production 2/998 23/18722 0.348986360954689 0.674383729683534 CD46/FERMT1 2 GO:1900048 positive regulation of hemostasis 2/998 23/18722 0.348986360954689 0.674383729683534 ANO6/NFE2L2 2 GO:2001169 regulation of ATP biosynthetic process 2/998 23/18722 0.348986360954689 0.674383729683534 PARP1/VCP 2 GO:0045739 positive regulation of DNA repair 5/998 73/18722 0.349246158930741 0.674383729683534 EGFR/PARP1/FUS/PRKDC/RIF1 5 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/998 56/18722 0.349269029891645 0.674383729683534 DCP2/DHX36/AGO2/TNRC6A 4 GO:0002711 positive regulation of T cell mediated immunity 4/998 56/18722 0.349269029891645 0.674383729683534 CD55/HSPD1/FZD5/GATA3 4 GO:0015800 acidic amino acid transport 4/998 56/18722 0.349269029891645 0.674383729683534 ITGB1/GJA1/ARL6IP5/SLC1A3 4 GO:0045599 negative regulation of fat cell differentiation 4/998 56/18722 0.349269029891645 0.674383729683534 YAP1/FERMT2/GATA3/ANKRD26 4 GO:0046622 positive regulation of organ growth 4/998 56/18722 0.349269029891645 0.674383729683534 TGFBR3/YAP1/MAPK14/FGFR2 4 GO:0055078 sodium ion homeostasis 4/998 56/18722 0.349269029891645 0.674383729683534 ATP6V1B1/SLC9A1/SLC1A3/EXT2 4 GO:1904062 regulation of cation transmembrane transport 21/998 357/18722 0.352216109998556 0.679822665546197 APP/AHNAK/UTRN/AKAP9/ITGB1/DLG1/SLC43A2/FXYD3/ANO6/ANK3/ATP2B4/KCNN4/DMD/SLC9A1/TSPAN13/HOMER1/FMR1/NEDD4/ACTN4/STOM/GPD1L 21 GO:0031023 microtubule organizing center organization 9/998 143/18722 0.353239330249587 0.681545655296784 SLC16A1/PARD6B/CEP152/UVRAG/PCM1/CTNNB1/GCC2/GOLGA2/PLK2 9 GO:0006402 mRNA catabolic process 14/998 232/18722 0.35532691441213 0.685320214313162 FUS/SND1/TTC37/PUM1/DCP2/FMR1/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/HNRNPU 14 GO:0051983 regulation of chromosome segregation 6/998 91/18722 0.357032410305414 0.688355322822957 TPR/PUM1/RAD21/WAPL/ANAPC5/HNRNPU 6 GO:0046470 phosphatidylcholine metabolic process 5/998 74/18722 0.359960561110028 0.691305777776742 CDS1/LPCAT3/SLC44A1/SLC44A2/ACSL3 5 GO:0009069 serine family amino acid metabolic process 3/998 40/18722 0.3600192319048 0.691305777776742 GLDC/CDO1/SERINC3 3 GO:0032892 positive regulation of organic acid transport 3/998 40/18722 0.3600192319048 0.691305777776742 ITGB1/PLA2R1/P2RX4 3 GO:0044275 cellular carbohydrate catabolic process 3/998 40/18722 0.3600192319048 0.691305777776742 AGL/GAA/GUSB 3 GO:0045429 positive regulation of nitric oxide biosynthetic process 3/998 40/18722 0.3600192319048 0.691305777776742 P2RX4/HSP90AA1/ASS1 3 GO:0045777 positive regulation of blood pressure 3/998 40/18722 0.3600192319048 0.691305777776742 ADRB1/NR2F2/ADH5 3 GO:0046365 monosaccharide catabolic process 3/998 40/18722 0.3600192319048 0.691305777776742 LRP5/FUT8/GLB1 3 GO:0055069 zinc ion homeostasis 3/998 40/18722 0.3600192319048 0.691305777776742 SLC39A10/SLC39A7/SLC30A7 3 GO:0060412 ventricular septum morphogenesis 3/998 40/18722 0.3600192319048 0.691305777776742 TGFBR3/TGFBR1/FGFR2 3 GO:0072210 metanephric nephron development 3/998 40/18722 0.3600192319048 0.691305777776742 LGR4/IRX2/CTNNB1 3 GO:2000142 regulation of DNA-templated transcription, initiation 3/998 40/18722 0.3600192319048 0.691305777776742 ZNF451/BCLAF1/DHX36 3 GO:0007612 learning 9/998 144/18722 0.36085022924877 0.692231465616841 APP/ITGB1/NF1/CLN3/TPBG/KRAS/EIF2AK4/MEIS2/SHANK2 9 GO:0031644 regulation of nervous system process 9/998 144/18722 0.36085022924877 0.692231465616841 APP/DAG1/AKAP9/SLC9A1/HOMER1/S1PR2/FMR1/DICER1/PARD3 9 GO:0006695 cholesterol biosynthetic process 4/998 57/18722 0.361562000907321 0.692231465616841 LPCAT3/MBTPS1/DHCR24/FDFT1 4 GO:0006949 syncytium formation 4/998 57/18722 0.361562000907321 0.692231465616841 ERVH48-1/ERVW-1/MYOF/MAPK14 4 GO:0050879 multicellular organismal movement 4/998 57/18722 0.361562000907321 0.692231465616841 DMD/HOMER1/GAA/ATP2A2 4 GO:0050881 musculoskeletal movement 4/998 57/18722 0.361562000907321 0.692231465616841 DMD/HOMER1/GAA/ATP2A2 4 GO:0097120 receptor localization to synapse 4/998 57/18722 0.361562000907321 0.692231465616841 DAG1/DLG1/CLSTN1/NSG1 4 GO:1902653 secondary alcohol biosynthetic process 4/998 57/18722 0.361562000907321 0.692231465616841 LPCAT3/MBTPS1/DHCR24/FDFT1 4 GO:0032414 positive regulation of ion transmembrane transporter activity 7/998 109/18722 0.362269519460386 0.693077743166976 TCAF1/AKAP9/ANK3/DMD/SLC9A1/ACTN4/ABCB1 7 GO:0043266 regulation of potassium ion transport 7/998 109/18722 0.362269519460386 0.693077743166976 AKAP9/ITGB1/DLG1/ANO6/ANK3/KCNN4/NEDD4 7 GO:0070509 calcium ion import 6/998 92/18722 0.366652955880563 0.699264650915314 ATP2B4/HOMER1/TRPV6/AFG3L2/CTNNB1/ATP2A2 6 GO:0061448 connective tissue development 15/998 252/18722 0.36758997190883 0.699264650915314 EFEMP1/BMP7/ITGB8/LRP5/GLG1/TRIP11/SERPINH1/SCIN/GLI3/CREB3L2/TGFBR1/MAPK14/ARID5B/CTNNB1/LTBP3 15 GO:0046651 lymphocyte proliferation 17/998 288/18722 0.367715023671689 0.699264650915314 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/HSPD1/DOCK8/PAWR/NCSTN/PURA/CTNNB1/BCL2/PNP 17 GO:0001779 natural killer cell differentiation 2/998 24/18722 0.368583857368118 0.699264650915314 PBX1/HECTD1 2 GO:0003181 atrioventricular valve morphogenesis 2/998 24/18722 0.368583857368118 0.699264650915314 MDM2/EFNA1 2 GO:0006582 melanin metabolic process 2/998 24/18722 0.368583857368118 0.699264650915314 OPN3/BCL2 2 GO:0006817 phosphate ion transport 2/998 24/18722 0.368583857368118 0.699264650915314 ANKH/SLC20A2 2 GO:0007035 vacuolar acidification 2/998 24/18722 0.368583857368118 0.699264650915314 CLN3/TMEM106B 2 GO:0033032 regulation of myeloid cell apoptotic process 2/998 24/18722 0.368583857368118 0.699264650915314 PIK3CB/BCL2 2 GO:0035458 cellular response to interferon-beta 2/998 24/18722 0.368583857368118 0.699264650915314 TLR3/UBE2G2 2 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 2/998 24/18722 0.368583857368118 0.699264650915314 PUM1/ANKRD17 2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 2/998 24/18722 0.368583857368118 0.699264650915314 GATA3/GPC1 2 GO:0044321 response to leptin 2/998 24/18722 0.368583857368118 0.699264650915314 LRP2/CCND1 2 GO:0048641 regulation of skeletal muscle tissue development 2/998 24/18722 0.368583857368118 0.699264650915314 CTNNB1/BCL2 2 GO:0050820 positive regulation of coagulation 2/998 24/18722 0.368583857368118 0.699264650915314 ANO6/NFE2L2 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/998 24/18722 0.368583857368118 0.699264650915314 PIK3CB/KRAS 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/998 24/18722 0.368583857368118 0.699264650915314 NRDC/SH3D19 2 GO:0051923 sulfation 2/998 24/18722 0.368583857368118 0.699264650915314 TPST2/EXT2 2 GO:0060479 lung cell differentiation 2/998 24/18722 0.368583857368118 0.699264650915314 YAP1/CTNNB1 2 GO:0070841 inclusion body assembly 2/998 24/18722 0.368583857368118 0.699264650915314 VCP/HSPA1B 2 GO:0071294 cellular response to zinc ion 2/998 24/18722 0.368583857368118 0.699264650915314 PARP1/P2RX4 2 GO:0072530 purine-containing compound transmembrane transport 2/998 24/18722 0.368583857368118 0.699264650915314 SLC19A1/SLC29A1 2 GO:2001026 regulation of endothelial cell chemotaxis 2/998 24/18722 0.368583857368118 0.699264650915314 MET/P2RX4 2 GO:0036465 synaptic vesicle recycling 5/998 75/18722 0.370684074175523 0.702738399154104 CANX/SYT7/STON1/KIAA1109/OPHN1 5 GO:0048662 negative regulation of smooth muscle cell proliferation 5/998 75/18722 0.370684074175523 0.702738399154104 GNA12/SF1/S1PR2/PPARG/PDCD4 5 GO:0003014 renal system process 7/998 110/18722 0.371073361617051 0.702965900218659 GJA1/CLDN4/GJA5/MAGED2/ATP6V1B1/CLN3/BCL2 7 GO:0090174 organelle membrane fusion 7/998 110/18722 0.371073361617051 0.702965900218659 EEA1/VAV3/SYT7/CLN3/UVRAG/USO1/ANXA2 7 GO:0045766 positive regulation of angiogenesis 11/998 181/18722 0.371569636450978 0.703392872290673 NRP1/ITGB8/ITGB1/GAB1/ISL1/TLR3/TJP1/AGO2/EMC10/ANXA3/NFE2L2 11 GO:1904018 positive regulation of vasculature development 11/998 181/18722 0.371569636450978 0.703392872290673 NRP1/ITGB8/ITGB1/GAB1/ISL1/TLR3/TJP1/AGO2/EMC10/ANXA3/NFE2L2 11 GO:0051051 negative regulation of transport 27/998 470/18722 0.371702917956324 0.703392872290673 ITGAV/LMAN1/GJA1/LRPAP1/GABRE/SLC43A2/ANK3/ARL6IP5/FRMD4A/CD47/ERBB3/PPP1R9A/FERMT1/ERLEC1/TPR/ERP29/NDFIP2/FMR1/NEDD4/PLA2R1/GOPC/RAB11FIP1/BCL2/ATXN2/LYPLA1/UBE2G2/VPS35 27 GO:0042098 T cell proliferation 12/998 199/18722 0.372429194758003 0.704511893417223 CD46/TFRC/DLG5/DLG1/CD55/CD24/IL6ST/DOCK8/PAWR/NCSTN/CTNNB1/PNP 12 GO:0035904 aorta development 4/998 58/18722 0.373846885645669 0.705875178679374 LRP2/ADAMTS6/LRP1/HECTD1 4 GO:0044380 protein localization to cytoskeleton 4/998 58/18722 0.373846885645669 0.705875178679374 GOLGB1/PCM1/GSK3B/HNRNPU 4 GO:0009167 purine ribonucleoside monophosphate metabolic process 3/998 41/18722 0.374772264949095 0.705875178679374 DLG1/AK3/PNP 3 GO:0010907 positive regulation of glucose metabolic process 3/998 41/18722 0.374772264949095 0.705875178679374 DDB1/SORBS1/PMAIP1 3 GO:0050691 regulation of defense response to virus by host 3/998 41/18722 0.374772264949095 0.705875178679374 TRIM44/HSP90AA1/EIF2AK4 3 GO:0050856 regulation of T cell receptor signaling pathway 3/998 41/18722 0.374772264949095 0.705875178679374 KCNN4/PAWR/EZR 3 GO:0071470 cellular response to osmotic stress 3/998 41/18722 0.374772264949095 0.705875178679374 SLC2A1/CLN3/ERRFI1 3 GO:1901385 regulation of voltage-gated calcium channel activity 3/998 41/18722 0.374772264949095 0.705875178679374 AHNAK/DMD/FMR1 3 GO:1902116 negative regulation of organelle assembly 3/998 41/18722 0.374772264949095 0.705875178679374 YAP1/LIMK2/MAP4 3 GO:1904407 positive regulation of nitric oxide metabolic process 3/998 41/18722 0.374772264949095 0.705875178679374 P2RX4/HSP90AA1/ASS1 3 GO:1905314 semi-lunar valve development 3/998 41/18722 0.374772264949095 0.705875178679374 GJA5/EFNA1/GATA3 3 GO:1905521 regulation of macrophage migration 3/998 41/18722 0.374772264949095 0.705875178679374 P2RX4/MMP14/PTK2 3 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 9/998 146/18722 0.376125049593898 0.708167646566802 ADGRG1/LGR5/ADRB1/LGR4/ATP2B4/ABCA1/S1PR2/ADGRG6/GNAS 9 GO:0050792 regulation of viral process 10/998 164/18722 0.377512228001431 0.710523194807307 DDB1/HACD3/P4HB/MPHOSPH8/FMR1/TOP2B/PKN2/BCL2/STOM/HEXIM1 10 GO:0016311 dephosphorylation 24/998 417/18722 0.378642178660972 0.712393086410427 HSP90B1/DLG1/SLC39A10/PTPN14/CTDSPL/PLPP3/CAMK2G/PTP4A1/SWAP70/PTPN1/PTPRM/PPP4R1/BOD1L1/BCL2/DUSP14/SGPP1/PTPRA/SPPL3/GSK3B/PPP2R2B/TNS3/PDP2/DUSP5/PPP6R2 24 GO:0015718 monocarboxylic acid transport 7/998 111/18722 0.379889311258042 0.714482022362478 SLC16A12/SLC16A4/SLC16A1/SLC16A2/PLA2R1/SLC5A6/P2RX4 7 GO:0006305 DNA alkylation 5/998 76/18722 0.381408502508871 0.716564876429944 DNMT1/PARP1/DNMT3A/ATRX/MPHOSPH8 5 GO:0006306 DNA methylation 5/998 76/18722 0.381408502508871 0.716564876429944 DNMT1/PARP1/DNMT3A/ATRX/MPHOSPH8 5 GO:0006809 nitric oxide biosynthetic process 5/998 76/18722 0.381408502508871 0.716564876429944 CD47/ATP2B4/P2RX4/HSP90AA1/ASS1 5 GO:0007093 mitotic cell cycle checkpoint signaling 8/998 129/18722 0.382249910658317 0.717887332211177 FOXO4/PRKDC/MDM2/TPR/CCND1/PLK2/XPC/PPP1R10 8 GO:0070372 regulation of ERK1 and ERK2 cascade 18/998 309/18722 0.38334125168465 0.719678056470895 EGFR/APP/SEMA6A/FBLN1/NRP1/DLG1/LRP1/GCNT2/EIF3A/FERMT2/DUSP9/EZR/TPBG/PTPN1/GAREM1/ERRFI1/ZDHHC17/FGFR2 18 GO:0032943 mononuclear cell proliferation 17/998 291/18722 0.383962129968305 0.720584572453098 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/HSPD1/DOCK8/PAWR/NCSTN/PURA/CTNNB1/BCL2/PNP 17 GO:0034249 negative regulation of cellular amide metabolic process 16/998 273/18722 0.384507798269101 0.72134934055443 ORMDL1/IGF2BP3/CALR/EIF2AK1/TPR/PUM1/DCP2/EIF4G1/RTN4/FMR1/PURA/EIF2AK4/DHX36/AGO2/TNRC6A/TIA1 16 GO:0006338 chromatin remodeling 15/998 255/18722 0.384960833289886 0.721557357378865 SMARCA2/SMARCA1/RERE/KDM5B/ATRX/BPTF/TP63/SMARCA5/SETD2/HP1BP3/BAZ1B/SMARCC1/GATA3/KDM4B/HDAC2 15 GO:0007018 microtubule-based movement 22/998 382/18722 0.385084718209897 0.721557357378865 APP/DST/KTN1/DYNC1H1/ARHGAP21/ATP2B4/ASH1L/CLN3/LRPPRC/SFPQ/RAB6A/VPS13A/PURA/PCM1/DYNC1LI2/SUN1/KIFC3/MAP4/FLOT2/TMF1/ARMCX3/HNRNPU 22 GO:0051702 biological process involved in interaction with symbiont 6/998 94/18722 0.385921659438786 0.721557357378865 DDB1/HSPD1/FMR1/EIF2AK4/STOM/PPIB 6 GO:0001836 release of cytochrome c from mitochondria 4/998 59/18722 0.38611190432328 0.721557357378865 IFI6/BCL2/PMAIP1/LMNA 4 GO:0032768 regulation of monooxygenase activity 4/998 59/18722 0.38611190432328 0.721557357378865 EGFR/ATP2B4/PIK3CB/KRAS 4 GO:0033013 tetrapyrrole metabolic process 4/998 59/18722 0.38611190432328 0.721557357378865 MTR/EIF2AK1/NFE2L1/ALAD 4 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 2/998 25/18722 0.387944117140735 0.721557357378865 GJA1/GJA5 2 GO:0003094 glomerular filtration 2/998 25/18722 0.387944117140735 0.721557357378865 GJA1/GJA5 2 GO:0010447 response to acidic pH 2/998 25/18722 0.387944117140735 0.721557357378865 SERPINF1/SLC9A1 2 GO:0010954 positive regulation of protein processing 2/998 25/18722 0.387944117140735 0.721557357378865 LPCAT3/MMP14 2 GO:0030318 melanocyte differentiation 2/998 25/18722 0.387944117140735 0.721557357378865 GLI3/BCL2 2 GO:0034389 lipid droplet organization 2/998 25/18722 0.387944117140735 0.721557357378865 CDS1/SQLE 2 GO:0035902 response to immobilization stress 2/998 25/18722 0.387944117140735 0.721557357378865 FOXO4/MDM2 2 GO:0036315 cellular response to sterol 2/998 25/18722 0.387944117140735 0.721557357378865 DAG1/ABCA1 2 GO:0046949 fatty-acyl-CoA biosynthetic process 2/998 25/18722 0.387944117140735 0.721557357378865 ACSL3/TECR 2 GO:0051788 response to misfolded protein 2/998 25/18722 0.387944117140735 0.721557357378865 DNAJB14/VCP 2 GO:0072207 metanephric epithelium development 2/998 25/18722 0.387944117140735 0.721557357378865 LGR4/YAP1 2 GO:0098703 calcium ion import across plasma membrane 2/998 25/18722 0.387944117140735 0.721557357378865 ATP2B4/TRPV6 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/998 25/18722 0.387944117140735 0.721557357378865 SORBS1/MYO1C 2 GO:1903055 positive regulation of extracellular matrix organization 2/998 25/18722 0.387944117140735 0.721557357378865 DAG1/PHLDB2 2 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/998 25/18722 0.387944117140735 0.721557357378865 EGFR/LIN28B 2 GO:1904385 cellular response to angiotensin 2/998 25/18722 0.387944117140735 0.721557357378865 AHCYL1/NFE2L2 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/998 25/18722 0.387944117140735 0.721557357378865 GNA12/NFE2L2 2 GO:1905048 regulation of metallopeptidase activity 2/998 25/18722 0.387944117140735 0.721557357378865 CLDN4/LRP1 2 GO:0002526 acute inflammatory response 7/998 112/18722 0.388712772358539 0.721557357378865 ANO6/IL6ST/EIF2AK1/ASH1L/B4GALT1/GATA3/ASS1 7 GO:0010633 negative regulation of epithelial cell migration 7/998 112/18722 0.388712772358539 0.721557357378865 SERPINF1/NR2F2/ATP2B4/TACSTD2/MARVELD3/PPARG/PTPRM 7 GO:0000266 mitochondrial fission 3/998 42/18722 0.389455781094358 0.721557357378865 PPARG/INF2/VPS35 3 GO:0007520 myoblast fusion 3/998 42/18722 0.389455781094358 0.721557357378865 ERVW-1/MYOF/MAPK14 3 GO:0010591 regulation of lamellipodium assembly 3/998 42/18722 0.389455781094358 0.721557357378865 WASF2/NCKAP1/OCLN 3 GO:0021879 forebrain neuron differentiation 3/998 42/18722 0.389455781094358 0.721557357378865 NRP2/NRP1/FGFR2 3 GO:0032965 regulation of collagen biosynthetic process 3/998 42/18722 0.389455781094358 0.721557357378865 SUCO/ERRFI1/HDAC2 3 GO:0045047 protein targeting to ER 3/998 42/18722 0.389455781094358 0.721557357378865 HSPA5/TRAM2/SEC63 3 GO:0045292 mRNA cis splicing, via spliceosome 3/998 42/18722 0.389455781094358 0.721557357378865 SNRNP200/PRPF4B/PRPF40A 3 GO:0046688 response to copper ion 3/998 42/18722 0.389455781094358 0.721557357378865 APP/SOD3/NFE2L2 3 GO:0071312 cellular response to alkaloid 3/998 42/18722 0.389455781094358 0.721557357378865 TGM2/MDM2/SLC1A3 3 GO:0006644 phospholipid metabolic process 22/998 383/18722 0.389836237572041 0.72200602921732 ISYNA1/PGAP1/PISD/IDH1/PLPP3/HADHA/HEXB/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/SERINC2/PIK3CB/SH3YL1/FDFT1/PTDSS1/SGPP1/ACSL3/SERINC3/FAR1 22 GO:0007098 centrosome cycle 8/998 130/18722 0.390435212439406 0.722602709729223 SLC16A1/PARD6B/CEP152/UVRAG/PCM1/CTNNB1/GOLGA2/PLK2 8 GO:0015918 sterol transport 8/998 130/18722 0.390435212439406 0.722602709729223 LRP1/LIMA1/ABCA1/LPCAT3/SYT7/OSBPL9/PPARG/ANXA2 8 GO:0140056 organelle localization by membrane tethering 5/998 77/18722 0.392125869158861 0.725474543897382 CLN3/AHCYL1/USO1/ESYT2/ATP2A2 5 GO:0032479 regulation of type I interferon production 6/998 95/18722 0.395557995023402 0.731047183014932 HSPD1/TLR3/SETD2/HSP90AA1/DHX36/YY1 6 GO:0032606 type I interferon production 6/998 95/18722 0.395557995023402 0.731047183014932 HSPD1/TLR3/SETD2/HSP90AA1/DHX36/YY1 6 GO:0048709 oligodendrocyte differentiation 6/998 95/18722 0.395557995023402 0.731047183014932 DAG1/NF1/GLI3/NCSTN/CTNNB1/HDAC2 6 GO:0002708 positive regulation of lymphocyte mediated immunity 7/998 113/18722 0.397539221339369 0.733343835999452 TFRC/CADM1/CD55/HSPD1/RIF1/FZD5/GATA3 7 GO:0044106 cellular amine metabolic process 7/998 113/18722 0.397539221339369 0.733343835999452 ALDH7A1/ATP2B4/SLC44A1/CLN3/SMS/AZIN1/GATA3 7 GO:0070371 ERK1 and ERK2 cascade 19/998 330/18722 0.398061221826633 0.733343835999452 EGFR/APP/SEMA6A/FBLN1/NRP1/ITGAV/DLG1/LRP1/GCNT2/EIF3A/FERMT2/DUSP9/EZR/TPBG/PTPN1/GAREM1/ERRFI1/ZDHHC17/FGFR2 19 GO:0002712 regulation of B cell mediated immunity 4/998 60/18722 0.39834574198323 0.733343835999452 CD46/TFRC/CD55/RIF1 4 GO:0002889 regulation of immunoglobulin mediated immune response 4/998 60/18722 0.39834574198323 0.733343835999452 CD46/TFRC/CD55/RIF1 4 GO:0006081 cellular aldehyde metabolic process 4/998 60/18722 0.39834574198323 0.733343835999452 IDH1/ALDH7A1/ADH5/ALDH1A3 4 GO:0033866 nucleoside bisphosphate biosynthetic process 4/998 60/18722 0.39834574198323 0.733343835999452 SLC26A2/ACSS1/ACSL3/TECR 4 GO:0034030 ribonucleoside bisphosphate biosynthetic process 4/998 60/18722 0.39834574198323 0.733343835999452 SLC26A2/ACSS1/ACSL3/TECR 4 GO:0034033 purine nucleoside bisphosphate biosynthetic process 4/998 60/18722 0.39834574198323 0.733343835999452 SLC26A2/ACSS1/ACSL3/TECR 4 GO:0051851 modulation by host of symbiont process 4/998 60/18722 0.39834574198323 0.733343835999452 FMR1/EIF2AK4/STOM/PPIB 4 GO:1903670 regulation of sprouting angiogenesis 4/998 60/18722 0.39834574198323 0.733343835999452 SEMA6A/TJP1/EPN2/PIK3CB 4 GO:0070588 calcium ion transmembrane transport 18/998 312/18722 0.399191143886422 0.734431011227707 ATP2B1/AHNAK/ITGAV/ANO6/ATP2B4/MCOLN3/DMD/SLC9A1/TSPAN13/TRPV6/AFG3L2/FMR1/P2RX4/TRPM7/TMEM165/ATP2A2/CUL5/ANXA2 18 GO:0034767 positive regulation of ion transmembrane transport 10/998 167/18722 0.399217623034712 0.734431011227707 TCAF1/AKAP9/ITGB1/ANO6/ANK3/KCNN4/DMD/SLC9A1/ACTN4/ABCB1 10 GO:0006816 calcium ion transport 24/998 422/18722 0.401370851593091 0.736187404039103 ATP2B1/AHNAK/ITGAV/GJA1/ANO6/ATP2B4/KCNN4/MCOLN3/CAMK2G/DMD/SLC9A1/TSPAN13/HOMER1/TRPV6/AFG3L2/FMR1/P2RX4/TRPM7/TMEM165/CTNNB1/BCL2/ATP2A2/CUL5/ANXA2 24 GO:0032371 regulation of sterol transport 5/998 78/18722 0.402828424561452 0.736187404039103 LRP1/ABCA1/LPCAT3/PPARG/ANXA2 5 GO:0032374 regulation of cholesterol transport 5/998 78/18722 0.402828424561452 0.736187404039103 LRP1/ABCA1/LPCAT3/PPARG/ANXA2 5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 5/998 78/18722 0.402828424561452 0.736187404039103 IFI6/MDM2/USP47/SIAH2/DHCR24 5 GO:0090559 regulation of membrane permeability 5/998 78/18722 0.402828424561452 0.736187404039103 SLC9A1/JAM3/BCL2/GSK3B/PMAIP1 5 GO:0001709 cell fate determination 3/998 43/18722 0.404052241596523 0.736187404039103 ISL1/CTNNB1/GATA3 3 GO:0002861 regulation of inflammatory response to antigenic stimulus 3/998 43/18722 0.404052241596523 0.736187404039103 YES1/MAPK14/PLK2 3 GO:0014014 negative regulation of gliogenesis 3/998 43/18722 0.404052241596523 0.736187404039103 NF1/DICER1/CTNNB1 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/998 43/18722 0.404052241596523 0.736187404039103 TP63/BCL2/SHISA5 3 GO:0140353 lipid export from cell 3/998 43/18722 0.404052241596523 0.736187404039103 KDM5B/P2RX4/TMF1 3 GO:1901381 positive regulation of potassium ion transmembrane transport 3/998 43/18722 0.404052241596523 0.736187404039103 AKAP9/ANO6/KCNN4 3 GO:0002718 regulation of cytokine production involved in immune response 6/998 96/18722 0.405187978925679 0.736187404039103 CD55/TLR3/DHX36/FZD5/DDX1/GATA3 6 GO:0006637 acyl-CoA metabolic process 6/998 96/18722 0.405187978925679 0.736187404039103 ACSS1/ACSF2/ACSL3/FASN/FAR1/TECR 6 GO:0035383 thioester metabolic process 6/998 96/18722 0.405187978925679 0.736187404039103 ACSS1/ACSF2/ACSL3/FASN/FAR1/TECR 6 GO:0043648 dicarboxylic acid metabolic process 6/998 96/18722 0.405187978925679 0.736187404039103 IDH1/SLC19A1/FOLR1/QPRT/ALDH18A1/ASS1 6 GO:1901655 cellular response to ketone 6/998 96/18722 0.405187978925679 0.736187404039103 EGFR/ATP2B1/SERPINF1/ERRFI1/GNAI1/ASS1 6 GO:1903008 organelle disassembly 7/998 114/18722 0.406364211925424 0.736187404039103 HUWE1/UFL1/GABARAPL1/VCP/FZD5/DENR/GOLGA2 7 GO:2000241 regulation of reproductive process 10/998 168/18722 0.406465976976452 0.736187404039103 BMP7/SERPINF1/GJA1/CALR/B4GALT1/PRDX4/CTNNB1/AGO2/HDAC2/PHLDA2 10 GO:0002092 positive regulation of receptor internalization 2/998 26/18722 0.407036749995999 0.736187404039103 AHI1/FMR1 2 GO:0002407 dendritic cell chemotaxis 2/998 26/18722 0.407036749995999 0.736187404039103 ANO6/CALR 2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 2/998 26/18722 0.407036749995999 0.736187404039103 TRAM2/SEC63 2 GO:0007214 gamma-aminobutyric acid signaling pathway 2/998 26/18722 0.407036749995999 0.736187404039103 GABRE/GABRA4 2 GO:0021680 cerebellar Purkinje cell layer development 2/998 26/18722 0.407036749995999 0.736187404039103 HSPA5/RERE 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/998 26/18722 0.407036749995999 0.736187404039103 BOD1L1/GSK3B 2 GO:0033522 histone H2A ubiquitination 2/998 26/18722 0.407036749995999 0.736187404039103 DDB1/UBR5 2 GO:0034114 regulation of heterotypic cell-cell adhesion 2/998 26/18722 0.407036749995999 0.736187404039103 BMP7/GCNT2 2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/998 26/18722 0.407036749995999 0.736187404039103 LRPPRC/ARMCX3 2 GO:0042634 regulation of hair cycle 2/998 26/18722 0.407036749995999 0.736187404039103 FERMT1/NIPBL 2 GO:0043501 skeletal muscle adaptation 2/998 26/18722 0.407036749995999 0.736187404039103 CAMK2G/ATP2A2 2 GO:0045026 plasma membrane fusion 2/998 26/18722 0.407036749995999 0.736187404039103 SPESP1/FOLR1 2 GO:0047497 mitochondrion transport along microtubule 2/998 26/18722 0.407036749995999 0.736187404039103 LRPPRC/ARMCX3 2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 2/998 26/18722 0.407036749995999 0.736187404039103 SLC39A10/KCNN4 2 GO:0070102 interleukin-6-mediated signaling pathway 2/998 26/18722 0.407036749995999 0.736187404039103 YAP1/IL6ST 2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/998 26/18722 0.407036749995999 0.736187404039103 EGFR/LIN28B 2 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 2/998 26/18722 0.407036749995999 0.736187404039103 ADRB1/ATP2B4 2 GO:0072273 metanephric nephron morphogenesis 2/998 26/18722 0.407036749995999 0.736187404039103 LGR4/CTNNB1 2 GO:0097186 amelogenesis 2/998 26/18722 0.407036749995999 0.736187404039103 CSF3R/PERP 2 GO:0097205 renal filtration 2/998 26/18722 0.407036749995999 0.736187404039103 GJA1/GJA5 2 GO:1902656 calcium ion import into cytosol 2/998 26/18722 0.407036749995999 0.736187404039103 ATP2B4/TRPV6 2 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 2/998 26/18722 0.407036749995999 0.736187404039103 DNMT1/PDCD4 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/998 26/18722 0.407036749995999 0.736187404039103 ZNRF3/GPC3 2 GO:0019748 secondary metabolic process 4/998 61/18722 0.410537555563091 0.736187404039103 OPN3/BCL2/ARL1/NFE2L2 4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 5/998 79/18722 0.413508654141917 0.736187404039103 IGF1R/ERBB3/PLXNB1/NEDD4/PTK2 5 GO:0000075 cell cycle checkpoint signaling 10/998 169/18722 0.413716792829693 0.736187404039103 FOXO4/PRKDC/MDM2/TPR/CCND1/EIF2AK4/MAPK14/PLK2/XPC/PPP1R10 10 GO:0018394 peptidyl-lysine acetylation 10/998 169/18722 0.413716792829693 0.736187404039103 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/PHF20/GATA3/USP22/BRD8/HDAC2 10 GO:0043410 positive regulation of MAPK cascade 27/998 480/18722 0.414521196701109 0.736187404039103 EGFR/APP/MAGED1/NRP1/IGF1R/LRP1/ARL6IP5/CD24/GCNT2/DVL3/EFNA1/MAP3K4/TLR3/SPAG9/FERMT2/ERP29/TPBG/TGFBR1/PTPN1/GAREM1/KRAS/RYK/FGFR2/CTNNB1/FZD5/EMC10/MAP3K13 27 GO:0006721 terpenoid metabolic process 6/998 97/18722 0.414806020272082 0.736187404039103 EGFR/LRP2/LRP1/FDFT1/ADH5/ALDH1A3 6 GO:0046916 cellular transition metal ion homeostasis 7/998 115/18722 0.415183379678648 0.736187404039103 APP/TFRC/SLC39A10/SLC40A1/SLC39A7/ACO1/SLC30A7 7 GO:0071675 regulation of mononuclear cell migration 7/998 115/18722 0.415183379678648 0.736187404039103 APP/ANO6/CALR/CD47/DOCK8/MIA3/PTK2 7 GO:0006378 mRNA polyadenylation 3/998 44/18722 0.418545266531753 0.736187404039103 APP/AHCYL1/ZC3H14 3 GO:0009126 purine nucleoside monophosphate metabolic process 3/998 44/18722 0.418545266531753 0.736187404039103 DLG1/AK3/PNP 3 GO:0021517 ventral spinal cord development 3/998 44/18722 0.418545266531753 0.736187404039103 LMO4/ISL1/GLI3 3 GO:0031295 T cell costimulation 3/998 44/18722 0.418545266531753 0.736187404039103 DPP4/CD24/YES1 3 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 3/998 44/18722 0.418545266531753 0.736187404039103 PRLR/IL10RB/OCIAD1 3 GO:0000050 urea cycle 1/998 10/18722 0.421855755865522 0.736187404039103 ASS1 1 GO:0000098 sulfur amino acid catabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 CDO1 1 GO:0000255 allantoin metabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 PNP 1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA 1/998 10/18722 0.421855755865522 0.736187404039103 DCP2 1 GO:0001553 luteinization 1/998 10/18722 0.421855755865522 0.736187404039103 PLEKHA1 1 GO:0001672 regulation of chromatin assembly or disassembly 1/998 10/18722 0.421855755865522 0.736187404039103 TLK1 1 GO:0001820 serotonin secretion 1/998 10/18722 0.421855755865522 0.736187404039103 SLC6A4 1 GO:0002084 protein depalmitoylation 1/998 10/18722 0.421855755865522 0.736187404039103 LYPLA1 1 GO:0002524 hypersensitivity 1/998 10/18722 0.421855755865522 0.736187404039103 GATA3 1 GO:0003056 regulation of vascular associated smooth muscle contraction 1/998 10/18722 0.421855755865522 0.736187404039103 ATP2B1 1 GO:0003163 sinoatrial node development 1/998 10/18722 0.421855755865522 0.736187404039103 ISL1 1 GO:0003183 mitral valve morphogenesis 1/998 10/18722 0.421855755865522 0.736187404039103 EFNA1 1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1/998 10/18722 0.421855755865522 0.736187404039103 DDX1 1 GO:0006560 proline metabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 ALDH18A1 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/998 10/18722 0.421855755865522 0.736187404039103 PISD 1 GO:0007028 cytoplasm organization 1/998 10/18722 0.421855755865522 0.736187404039103 TFCP2L1 1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 GNAS 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/998 10/18722 0.421855755865522 0.736187404039103 AK3 1 GO:0009169 purine ribonucleoside monophosphate catabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 PNP 1 GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 PNP 1 GO:0009750 response to fructose 1/998 10/18722 0.421855755865522 0.736187404039103 KRT18 1 GO:0009950 dorsal/ventral axis specification 1/998 10/18722 0.421855755865522 0.736187404039103 CTNNB1 1 GO:0010968 regulation of microtubule nucleation 1/998 10/18722 0.421855755865522 0.736187404039103 HSPA1B 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/998 10/18722 0.421855755865522 0.736187404039103 SLC2A1 1 GO:0019532 oxalate transport 1/998 10/18722 0.421855755865522 0.736187404039103 SLC26A2 1 GO:0021548 pons development 1/998 10/18722 0.421855755865522 0.736187404039103 BCL2 1 GO:0030300 regulation of intestinal cholesterol absorption 1/998 10/18722 0.421855755865522 0.736187404039103 LPCAT3 1 GO:0031125 rRNA 3'-end processing 1/998 10/18722 0.421855755865522 0.736187404039103 RPS21 1 GO:0031340 positive regulation of vesicle fusion 1/998 10/18722 0.421855755865522 0.736187404039103 ANXA2 1 GO:0032275 luteinizing hormone secretion 1/998 10/18722 0.421855755865522 0.736187404039103 TMF1 1 GO:0032380 regulation of intracellular sterol transport 1/998 10/18722 0.421855755865522 0.736187404039103 ANXA2 1 GO:0032383 regulation of intracellular cholesterol transport 1/998 10/18722 0.421855755865522 0.736187404039103 ANXA2 1 GO:0033131 regulation of glucokinase activity 1/998 10/18722 0.421855755865522 0.736187404039103 RANBP2 1 GO:0035376 sterol import 1/998 10/18722 0.421855755865522 0.736187404039103 LRP1 1 GO:0035520 monoubiquitinated protein deubiquitination 1/998 10/18722 0.421855755865522 0.736187404039103 USP47 1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 GATA3 1 GO:0035871 protein K11-linked deubiquitination 1/998 10/18722 0.421855755865522 0.736187404039103 OTUD7B 1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling 1/998 10/18722 0.421855755865522 0.736187404039103 LPCAT3 1 GO:0038007 netrin-activated signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 PTK2 1 GO:0040015 negative regulation of multicellular organism growth 1/998 10/18722 0.421855755865522 0.736187404039103 ADRB1 1 GO:0042045 epithelial fluid transport 1/998 10/18722 0.421855755865522 0.736187404039103 AHCYL1 1 GO:0042989 sequestering of actin monomers 1/998 10/18722 0.421855755865522 0.736187404039103 SCIN 1 GO:0043101 purine-containing compound salvage 1/998 10/18722 0.421855755865522 0.736187404039103 PNP 1 GO:0045792 negative regulation of cell size 1/998 10/18722 0.421855755865522 0.736187404039103 RDX 1 GO:0048251 elastic fiber assembly 1/998 10/18722 0.421855755865522 0.736187404039103 LTBP3 1 GO:0048262 determination of dorsal/ventral asymmetry 1/998 10/18722 0.421855755865522 0.736187404039103 CTNNB1 1 GO:0048280 vesicle fusion with Golgi apparatus 1/998 10/18722 0.421855755865522 0.736187404039103 USO1 1 GO:0048672 positive regulation of collateral sprouting 1/998 10/18722 0.421855755865522 0.736187404039103 LRP1 1 GO:0048703 embryonic viscerocranium morphogenesis 1/998 10/18722 0.421855755865522 0.736187404039103 NIPBL 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 SLC39A10 1 GO:0051409 response to nitrosative stress 1/998 10/18722 0.421855755865522 0.736187404039103 ADH5 1 GO:0060068 vagina development 1/998 10/18722 0.421855755865522 0.736187404039103 LRP2 1 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 CD47 1 GO:0060439 trachea morphogenesis 1/998 10/18722 0.421855755865522 0.736187404039103 CTNNB1 1 GO:0060736 prostate gland growth 1/998 10/18722 0.421855755865522 0.736187404039103 FGFR2 1 GO:0061085 regulation of histone H3-K27 methylation 1/998 10/18722 0.421855755865522 0.736187404039103 GATA3 1 GO:0070091 glucagon secretion 1/998 10/18722 0.421855755865522 0.736187404039103 SYT7 1 GO:0070092 regulation of glucagon secretion 1/998 10/18722 0.421855755865522 0.736187404039103 SYT7 1 GO:0070391 response to lipoteichoic acid 1/998 10/18722 0.421855755865522 0.736187404039103 MAPK14 1 GO:0070508 cholesterol import 1/998 10/18722 0.421855755865522 0.736187404039103 LRP1 1 GO:0070544 histone H3-K36 demethylation 1/998 10/18722 0.421855755865522 0.736187404039103 KDM4B 1 GO:0070561 vitamin D receptor signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 TRIM24 1 GO:0071073 positive regulation of phospholipid biosynthetic process 1/998 10/18722 0.421855755865522 0.736187404039103 ACSL3 1 GO:0071223 cellular response to lipoteichoic acid 1/998 10/18722 0.421855755865522 0.736187404039103 MAPK14 1 GO:0071421 manganese ion transmembrane transport 1/998 10/18722 0.421855755865522 0.736187404039103 TMEM165 1 GO:0071600 otic vesicle morphogenesis 1/998 10/18722 0.421855755865522 0.736187404039103 FGFR2 1 GO:0071838 cell proliferation in bone marrow 1/998 10/18722 0.421855755865522 0.736187404039103 FGFR2 1 GO:0072070 loop of Henle development 1/998 10/18722 0.421855755865522 0.736187404039103 IRX2 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/998 10/18722 0.421855755865522 0.736187404039103 BMP7 1 GO:0072378 blood coagulation, fibrin clot formation 1/998 10/18722 0.421855755865522 0.736187404039103 FBLN1 1 GO:0090179 planar cell polarity pathway involved in neural tube closure 1/998 10/18722 0.421855755865522 0.736187404039103 DVL3 1 GO:0090527 actin filament reorganization 1/998 10/18722 0.421855755865522 0.736187404039103 NEDD9 1 GO:0090647 modulation of age-related behavioral decline 1/998 10/18722 0.421855755865522 0.736187404039103 APP 1 GO:0098885 modification of postsynaptic actin cytoskeleton 1/998 10/18722 0.421855755865522 0.736187404039103 MYH10 1 GO:0098917 retrograde trans-synaptic signaling 1/998 10/18722 0.421855755865522 0.736187404039103 DAG1 1 GO:0099532 synaptic vesicle endosomal processing 1/998 10/18722 0.421855755865522 0.736187404039103 EEA1 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 ACSL3 1 GO:1901978 positive regulation of cell cycle checkpoint 1/998 10/18722 0.421855755865522 0.736187404039103 TPR 1 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1/998 10/18722 0.421855755865522 0.736187404039103 EFNA1 1 GO:1904338 regulation of dopaminergic neuron differentiation 1/998 10/18722 0.421855755865522 0.736187404039103 GSK3B 1 GO:1904779 regulation of protein localization to centrosome 1/998 10/18722 0.421855755865522 0.736187404039103 GSK3B 1 GO:1990253 cellular response to leucine starvation 1/998 10/18722 0.421855755865522 0.736187404039103 EIF2AK4 1 GO:1990535 neuron projection maintenance 1/998 10/18722 0.421855755865522 0.736187404039103 APP 1 GO:1990700 nucleolar chromatin organization 1/998 10/18722 0.421855755865522 0.736187404039103 SMARCA5 1 GO:2000425 regulation of apoptotic cell clearance 1/998 10/18722 0.421855755865522 0.736187404039103 TGM2 1 GO:2000510 positive regulation of dendritic cell chemotaxis 1/998 10/18722 0.421855755865522 0.736187404039103 CALR 1 GO:2000659 regulation of interleukin-1-mediated signaling pathway 1/998 10/18722 0.421855755865522 0.736187404039103 OTUD4 1 GO:2001223 negative regulation of neuron migration 1/998 10/18722 0.421855755865522 0.736187404039103 ADGRG1 1 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/998 10/18722 0.421855755865522 0.736187404039103 CTNNA1 1 GO:0016573 histone acetylation 9/998 152/18722 0.422155509452649 0.736187404039103 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/PHF20/GATA3/USP22/BRD8 9 GO:0098754 detoxification 9/998 152/18722 0.422155509452649 0.736187404039103 BMP7/MGST3/PRDX4/GPX8/SLC22A5/ADH5/ABCB1/SOD3/NFE2L2 9 GO:0046700 heterocycle catabolic process 25/998 445/18722 0.422407786705255 0.736187404039103 KCNQ1OT1/NUDT4/LIN28B/FUS/SND1/QPRT/TTC37/TET2/PUM1/LRPPRC/DCP2/SMPDL3A/FMR1/DICER1/VCP/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/NFE2L2/PNP/HNRNPU 25 GO:0031124 mRNA 3'-end processing 4/998 62/18722 0.422676978739068 0.736187404039103 APP/AHCYL1/DHX36/ZC3H14 4 GO:0032623 interleukin-2 production 4/998 62/18722 0.422676978739068 0.736187404039103 EZR/GATA3/SPTBN1/PNP 4 GO:0032663 regulation of interleukin-2 production 4/998 62/18722 0.422676978739068 0.736187404039103 EZR/GATA3/SPTBN1/PNP 4 GO:0048488 synaptic vesicle endocytosis 4/998 62/18722 0.422676978739068 0.736187404039103 CANX/STON1/KIAA1109/OPHN1 4 GO:0048663 neuron fate commitment 4/998 62/18722 0.422676978739068 0.736187404039103 ISL1/GLI3/ESRP1/TGFBR1 4 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 4/998 62/18722 0.422676978739068 0.736187404039103 BMP7/LRP1/TGFBR1/PPARG 4 GO:0140238 presynaptic endocytosis 4/998 62/18722 0.422676978739068 0.736187404039103 CANX/STON1/KIAA1109/OPHN1 4 GO:0050670 regulation of lymphocyte proliferation 13/998 225/18722 0.423246789267349 0.736187404039103 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/PAWR/CTNNB1/BCL2/PNP 13 GO:0007006 mitochondrial membrane organization 7/998 116/18722 0.423992446208899 0.736187404039103 SLC9A1/AFG3L2/HSP90AA1/BCL2/GSK3B/PMAIP1/HSPA9 7 GO:0031123 RNA 3'-end processing 7/998 116/18722 0.423992446208899 0.736187404039103 APP/LIN28B/AHCYL1/DHX36/ZC3H14/INTS6/RPS21 7 GO:1990748 cellular detoxification 7/998 116/18722 0.423992446208899 0.736187404039103 BMP7/MGST3/PRDX4/GPX8/ADH5/SOD3/NFE2L2 7 GO:0021766 hippocampus development 5/998 80/18722 0.424159284845504 0.736187404039103 CDK6/ATP2B4/GLI3/GSK3B/ANXA3 5 GO:0002367 cytokine production involved in immune response 6/998 98/18722 0.424406666631538 0.736187404039103 CD55/TLR3/DHX36/FZD5/DDX1/GATA3 6 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 6/998 98/18722 0.424406666631538 0.736187404039103 PTTG1IP/MDM2/USP47/PTPN1/BCL2/NFE2L2 6 GO:0003272 endocardial cushion formation 2/998 27/18722 0.42583527297416 0.736187404039103 BMP7/TGFBR1 2 GO:0003401 axis elongation 2/998 27/18722 0.42583527297416 0.736187404039103 YAP1/FGFR2 2 GO:0006783 heme biosynthetic process 2/998 27/18722 0.42583527297416 0.736187404039103 NFE2L1/ALAD 2 GO:0007263 nitric oxide mediated signal transduction 2/998 27/18722 0.42583527297416 0.736187404039103 EGFR/ATP2B4 2 GO:0010561 negative regulation of glycoprotein biosynthetic process 2/998 27/18722 0.42583527297416 0.736187404039103 TMEM59/AGO2 2 GO:0016556 mRNA modification 2/998 27/18722 0.42583527297416 0.736187404039103 ZC3H13/CMTR1 2 GO:0018904 ether metabolic process 2/998 27/18722 0.42583527297416 0.736187404039103 FASN/FAR1 2 GO:0032703 negative regulation of interleukin-2 production 2/998 27/18722 0.42583527297416 0.736187404039103 EZR/GATA3 2 GO:0032967 positive regulation of collagen biosynthetic process 2/998 27/18722 0.42583527297416 0.736187404039103 SUCO/HDAC2 2 GO:0034698 response to gonadotropin 2/998 27/18722 0.42583527297416 0.736187404039103 TGFBR3/CTSV 2 GO:0035235 ionotropic glutamate receptor signaling pathway 2/998 27/18722 0.42583527297416 0.736187404039103 APP/CLN3 2 GO:0035459 vesicle cargo loading 2/998 27/18722 0.42583527297416 0.736187404039103 SEC31A/MIA3 2 GO:0039529 RIG-I signaling pathway 2/998 27/18722 0.42583527297416 0.736187404039103 PUM1/ANKRD17 2 GO:0042402 cellular biogenic amine catabolic process 2/998 27/18722 0.42583527297416 0.736187404039103 ALDH7A1/SLC44A1 2 GO:0045830 positive regulation of isotype switching 2/998 27/18722 0.42583527297416 0.736187404039103 TFRC/RIF1 2 GO:0048520 positive regulation of behavior 2/998 27/18722 0.42583527297416 0.736187404039103 GJA1/HDAC2 2 GO:0048873 homeostasis of number of cells within a tissue 2/998 27/18722 0.42583527297416 0.736187404039103 KRAS/BCL2 2 GO:0051953 negative regulation of amine transport 2/998 27/18722 0.42583527297416 0.736187404039103 SLC43A2/ARL6IP5 2 GO:0061437 renal system vasculature development 2/998 27/18722 0.42583527297416 0.736187404039103 NRP1/BMP7 2 GO:0061440 kidney vasculature development 2/998 27/18722 0.42583527297416 0.736187404039103 NRP1/BMP7 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/998 27/18722 0.42583527297416 0.736187404039103 AKAP9/GJA5 2 GO:1903319 positive regulation of protein maturation 2/998 27/18722 0.42583527297416 0.736187404039103 LPCAT3/MMP14 2 GO:0042129 regulation of T cell proliferation 10/998 171/18722 0.428216040817004 0.740058242007805 CD46/TFRC/DLG5/DLG1/CD55/CD24/IL6ST/PAWR/CTNNB1/PNP 10 GO:0070661 leukocyte proliferation 18/998 318/18722 0.431054189383376 0.742072023542797 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/HSPD1/DOCK8/PAWR/NCSTN/PURA/CTNNB1/PTK2/BCL2/PNP 18 GO:0006836 neurotransmitter transport 12/998 208/18722 0.431485515914494 0.742072023542797 SLC6A4/ITGB1/SLC38A1/PPP1R9A/SYT7/FMR1/SLC1A3/SLC38A2/ATP2A2/GSK3B/MCTP2/SLC29A1 12 GO:0002702 positive regulation of production of molecular mediator of immune response 7/998 117/18722 0.432787223066765 0.742072023542797 TFRC/CD55/RIF1/DHX36/FZD5/DDX1/GATA3 7 GO:0030301 cholesterol transport 7/998 117/18722 0.432787223066765 0.742072023542797 LRP1/LIMA1/ABCA1/LPCAT3/SYT7/PPARG/ANXA2 7 GO:0051225 spindle assembly 7/998 117/18722 0.432787223066765 0.742072023542797 DYNC1H1/TPR/GOLGA2/HSPA1B/STAG1/GPSM2/HNRNPU 7 GO:0002920 regulation of humoral immune response 3/998 45/18722 0.432919609452257 0.742072023542797 CD46/CD55/CD59 3 GO:0006903 vesicle targeting 3/998 45/18722 0.432919609452257 0.742072023542797 TRIP11/TMED9/TFG 3 GO:0022602 ovulation cycle process 3/998 45/18722 0.432919609452257 0.742072023542797 HSPA5/ADAMTS1/PLEKHA1 3 GO:0035305 negative regulation of dephosphorylation 3/998 45/18722 0.432919609452257 0.742072023542797 SWAP70/BOD1L1/GSK3B 3 GO:0035384 thioester biosynthetic process 3/998 45/18722 0.432919609452257 0.742072023542797 ACSS1/ACSL3/TECR 3 GO:0043631 RNA polyadenylation 3/998 45/18722 0.432919609452257 0.742072023542797 APP/AHCYL1/ZC3H14 3 GO:0048599 oocyte development 3/998 45/18722 0.432919609452257 0.742072023542797 ZFX/CTNNB1/BCL2 3 GO:0060119 inner ear receptor cell development 3/998 45/18722 0.432919609452257 0.742072023542797 TRIP11/MYO7A/TRIOBP 3 GO:0071364 cellular response to epidermal growth factor stimulus 3/998 45/18722 0.432919609452257 0.742072023542797 EGFR/GAREM1/ERRFI1 3 GO:0071616 acyl-CoA biosynthetic process 3/998 45/18722 0.432919609452257 0.742072023542797 ACSS1/ACSL3/TECR 3 GO:0017148 negative regulation of translation 14/998 245/18722 0.433714979913904 0.742072023542797 IGF2BP3/CALR/EIF2AK1/TPR/PUM1/DCP2/EIF4G1/FMR1/PURA/EIF2AK4/DHX36/AGO2/TNRC6A/TIA1 14 GO:0070663 regulation of leukocyte proliferation 14/998 245/18722 0.433714979913904 0.742072023542797 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/PAWR/CTNNB1/PTK2/BCL2/PNP 14 GO:0030838 positive regulation of actin filament polymerization 6/998 99/18722 0.433984608879587 0.742072023542797 DLG1/IQGAP2/SCIN/WASF2/MYO1C/NCKAP1 6 GO:0042100 B cell proliferation 6/998 99/18722 0.433984608879587 0.742072023542797 TFRC/SLC39A10/VAV3/HSPD1/PAWR/BCL2 6 GO:0046902 regulation of mitochondrial membrane permeability 4/998 63/18722 0.434754124713654 0.742072023542797 SLC9A1/BCL2/GSK3B/PMAIP1 4 GO:0050854 regulation of antigen receptor-mediated signaling pathway 4/998 63/18722 0.434754124713654 0.742072023542797 SLC39A10/KCNN4/PAWR/EZR 4 GO:0021954 central nervous system neuron development 5/998 81/18722 0.43477329064382 0.742072023542797 NRP2/NRP1/MYCBP2/HSP90AA1/FGFR2 5 GO:0046209 nitric oxide metabolic process 5/998 81/18722 0.43477329064382 0.742072023542797 CD47/ATP2B4/P2RX4/HSP90AA1/ASS1 5 GO:0032944 regulation of mononuclear cell proliferation 13/998 227/18722 0.435853206957005 0.742072023542797 CD46/TFRC/DLG5/DLG1/SLC39A10/CD55/CD24/IL6ST/VAV3/PAWR/CTNNB1/BCL2/PNP 13 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 12/998 209/18722 0.438058707835873 0.742072023542797 IFI6/ARL6IP5/HSPD1/MDM2/USP47/TP63/SIAH2/DHCR24/PPARG/BCAP31/VCP/PMAIP1 12 GO:0009308 amine metabolic process 7/998 118/18722 0.44156361532314 0.742072023542797 ALDH7A1/ATP2B4/SLC44A1/CLN3/SMS/AZIN1/GATA3 7 GO:0051588 regulation of neurotransmitter transport 6/998 100/18722 0.443534685527977 0.742072023542797 ITGB1/PPP1R9A/FMR1/ATP2A2/GSK3B/MCTP2 6 GO:0060079 excitatory postsynaptic potential 6/998 100/18722 0.443534685527977 0.742072023542797 APP/PPP1R9A/S1PR2/P2RX4/GSK3B/SLC29A1 6 GO:0003156 regulation of animal organ formation 2/998 28/18722 0.444316780928042 0.742072023542797 BMP7/CTNNB1 2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 2/998 28/18722 0.444316780928042 0.742072023542797 VCP/YME1L1 2 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 2/998 28/18722 0.444316780928042 0.742072023542797 LRP1/PARD3 2 GO:0009312 oligosaccharide biosynthetic process 2/998 28/18722 0.444316780928042 0.742072023542797 FUT8/B4GALT1 2 GO:0010460 positive regulation of heart rate 2/998 28/18722 0.444316780928042 0.742072023542797 ADRB1/ATP2A2 2 GO:0010575 positive regulation of vascular endothelial growth factor production 2/998 28/18722 0.444316780928042 0.742072023542797 IL6ST/ISL1 2 GO:0010714 positive regulation of collagen metabolic process 2/998 28/18722 0.444316780928042 0.742072023542797 SUCO/HDAC2 2 GO:0030262 apoptotic nuclear changes 2/998 28/18722 0.444316780928042 0.742072023542797 DICER1/BLCAP 2 GO:0034123 positive regulation of toll-like receptor signaling pathway 2/998 28/18722 0.444316780928042 0.742072023542797 TLR3/RTN4 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 2/998 28/18722 0.444316780928042 0.742072023542797 EGFR/ERRFI1 2 GO:0044331 cell-cell adhesion mediated by cadherin 2/998 28/18722 0.444316780928042 0.742072023542797 CTNND1/TJP1 2 GO:0045686 negative regulation of glial cell differentiation 2/998 28/18722 0.444316780928042 0.742072023542797 NF1/CTNNB1 2 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 2/998 28/18722 0.444316780928042 0.742072023542797 LEPROT/SUZ12 2 GO:0051894 positive regulation of focal adhesion assembly 2/998 28/18722 0.444316780928042 0.742072023542797 NRP1/FERMT2 2 GO:0061082 myeloid leukocyte cytokine production 2/998 28/18722 0.444316780928042 0.742072023542797 DHX36/DDX1 2 GO:0070076 histone lysine demethylation 2/998 28/18722 0.444316780928042 0.742072023542797 KDM5B/KDM4B 2 GO:0071280 cellular response to copper ion 2/998 28/18722 0.444316780928042 0.742072023542797 APP/NFE2L2 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/998 28/18722 0.444316780928042 0.742072023542797 AKAP9/GJA5 2 GO:1903649 regulation of cytoplasmic transport 2/998 28/18722 0.444316780928042 0.742072023542797 EZR/RDX 2 GO:1990776 response to angiotensin 2/998 28/18722 0.444316780928042 0.742072023542797 AHCYL1/NFE2L2 2 GO:0002685 regulation of leukocyte migration 12/998 210/18722 0.44462754043193 0.742072023542797 APP/DPP4/ANO6/CALR/CD47/DOCK8/P2RX4/SWAP70/MIA3/JAM3/MMP14/PTK2 12 GO:0016575 histone deacetylation 5/998 82/18722 0.445343897064818 0.742072023542797 TBL1X/RCOR1/SFPQ/NIPBL/HDAC2 5 GO:0050000 chromosome localization 5/998 82/18722 0.445343897064818 0.742072023542797 EML4/DYNC1H1/SUN1/LMNA/HNRNPU 5 GO:2001057 reactive nitrogen species metabolic process 5/998 82/18722 0.445343897064818 0.742072023542797 CD47/ATP2B4/P2RX4/HSP90AA1/ASS1 5 GO:0030858 positive regulation of epithelial cell differentiation 4/998 64/18722 0.446759587108377 0.742072023542797 NCOA3/CD24/AHI1/CTNNB1 4 GO:0046530 photoreceptor cell differentiation 4/998 64/18722 0.446759587108377 0.742072023542797 MYO7A/AHI1/TUG1/PRKCI 4 GO:0046579 positive regulation of Ras protein signal transduction 4/998 64/18722 0.446759587108377 0.742072023542797 ADGRG1/NET1/PIK3CB/KRAS 4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 3/998 46/18722 0.447161128891558 0.742072023542797 TENM3/CADM1/CD164 3 GO:0031057 negative regulation of histone modification 3/998 46/18722 0.447161128891558 0.742072023542797 DNMT1/ZNF451/UBR5 3 GO:0031294 lymphocyte costimulation 3/998 46/18722 0.447161128891558 0.742072023542797 DPP4/CD24/YES1 3 GO:0033047 regulation of mitotic sister chromatid segregation 3/998 46/18722 0.447161128891558 0.742072023542797 TPR/RAD21/HNRNPU 3 GO:0042398 cellular modified amino acid biosynthetic process 3/998 46/18722 0.447161128891558 0.742072023542797 ALDH7A1/PTDSS1/NFE2L2 3 GO:0071827 plasma lipoprotein particle organization 3/998 46/18722 0.447161128891558 0.742072023542797 ABCA1/LPCAT3/ACSL3 3 GO:0072599 establishment of protein localization to endoplasmic reticulum 3/998 46/18722 0.447161128891558 0.742072023542797 HSPA5/TRAM2/SEC63 3 GO:2000107 negative regulation of leukocyte apoptotic process 3/998 46/18722 0.447161128891558 0.742072023542797 SLC39A10/EFNA1/DOCK8 3 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/998 11/18722 0.452690939472095 0.742072023542797 DDX1 1 GO:0001731 formation of translation preinitiation complex 1/998 11/18722 0.452690939472095 0.742072023542797 DENR 1 GO:0001967 suckling behavior 1/998 11/18722 0.452690939472095 0.742072023542797 APP 1 GO:0002357 defense response to tumor cell 1/998 11/18722 0.452690939472095 0.742072023542797 RBMS3 1 GO:0006002 fructose 6-phosphate metabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 GFPT1 1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1/998 11/18722 0.452690939472095 0.742072023542797 UQCRC1 1 GO:0006527 arginine catabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 ATP2B4 1 GO:0009120 deoxyribonucleoside metabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0009128 purine nucleoside monophosphate catabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0009155 purine deoxyribonucleotide catabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0009235 cobalamin metabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 MTR 1 GO:0010269 response to selenium ion 1/998 11/18722 0.452690939472095 0.742072023542797 ALAD 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/998 11/18722 0.452690939472095 0.742072023542797 VCP 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/998 11/18722 0.452690939472095 0.742072023542797 ANXA2 1 GO:0014010 Schwann cell proliferation 1/998 11/18722 0.452690939472095 0.742072023542797 DICER1 1 GO:0014854 response to inactivity 1/998 11/18722 0.452690939472095 0.742072023542797 DAG1 1 GO:0018342 protein prenylation 1/998 11/18722 0.452690939472095 0.742072023542797 CHML 1 GO:0021860 pyramidal neuron development 1/998 11/18722 0.452690939472095 0.742072023542797 FGFR2 1 GO:0030432 peristalsis 1/998 11/18722 0.452690939472095 0.742072023542797 DLG1 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/998 11/18722 0.452690939472095 0.742072023542797 DHX36 1 GO:0032276 regulation of gonadotropin secretion 1/998 11/18722 0.452690939472095 0.742072023542797 GJA1 1 GO:0032308 positive regulation of prostaglandin secretion 1/998 11/18722 0.452690939472095 0.742072023542797 P2RX4 1 GO:0032377 regulation of intracellular lipid transport 1/998 11/18722 0.452690939472095 0.742072023542797 ANXA2 1 GO:0032610 interleukin-1 alpha production 1/998 11/18722 0.452690939472095 0.742072023542797 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/998 11/18722 0.452690939472095 0.742072023542797 ISL1 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/998 11/18722 0.452690939472095 0.742072023542797 BCL2 1 GO:0033234 negative regulation of protein sumoylation 1/998 11/18722 0.452690939472095 0.742072023542797 CTNNB1 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 RTN4 1 GO:0034350 regulation of glial cell apoptotic process 1/998 11/18722 0.452690939472095 0.742072023542797 PRKCI 1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1/998 11/18722 0.452690939472095 0.742072023542797 TTC37 1 GO:0034770 histone H4-K20 methylation 1/998 11/18722 0.452690939472095 0.742072023542797 NSD1 1 GO:0035404 histone-serine phosphorylation 1/998 11/18722 0.452690939472095 0.742072023542797 RPS6KA5 1 GO:0039530 MDA-5 signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 ANKRD17 1 GO:0042451 purine nucleoside biosynthetic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0042455 ribonucleoside biosynthetic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0043312 neutrophil degranulation 1/998 11/18722 0.452690939472095 0.742072023542797 ANXA3 1 GO:0044068 modulation by symbiont of host cellular process 1/998 11/18722 0.452690939472095 0.742072023542797 ANO6 1 GO:0045060 negative thymic T cell selection 1/998 11/18722 0.452690939472095 0.742072023542797 GLI3 1 GO:0045161 neuronal ion channel clustering 1/998 11/18722 0.452690939472095 0.742072023542797 NRCAM 1 GO:0046129 purine ribonucleoside biosynthetic process 1/998 11/18722 0.452690939472095 0.742072023542797 PNP 1 GO:0046349 amino sugar biosynthetic process 1/998 11/18722 0.452690939472095 0.742072023542797 GFPT1 1 GO:0046598 positive regulation of viral entry into host cell 1/998 11/18722 0.452690939472095 0.742072023542797 P4HB 1 GO:0046710 GDP metabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 DLG1 1 GO:0048102 autophagic cell death 1/998 11/18722 0.452690939472095 0.742072023542797 CTSV 1 GO:0048680 positive regulation of axon regeneration 1/998 11/18722 0.452690939472095 0.742072023542797 LRP1 1 GO:0048853 forebrain morphogenesis 1/998 11/18722 0.452690939472095 0.742072023542797 NF1 1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 ZDHHC17 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/998 11/18722 0.452690939472095 0.742072023542797 DNMT1 1 GO:0051610 serotonin uptake 1/998 11/18722 0.452690939472095 0.742072023542797 SLC6A4 1 GO:0052646 alditol phosphate metabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 GPD1L 1 GO:0055015 ventricular cardiac muscle cell development 1/998 11/18722 0.452690939472095 0.742072023542797 LMNA 1 GO:0060159 regulation of dopamine receptor signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 VPS35 1 GO:0060174 limb bud formation 1/998 11/18722 0.452690939472095 0.742072023542797 FGFR2 1 GO:0060379 cardiac muscle cell myoblast differentiation 1/998 11/18722 0.452690939472095 0.742072023542797 ISL1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/998 11/18722 0.452690939472095 0.742072023542797 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/998 11/18722 0.452690939472095 0.742072023542797 GLI3 1 GO:0060746 parental behavior 1/998 11/18722 0.452690939472095 0.742072023542797 ZFX 1 GO:0060837 blood vessel endothelial cell differentiation 1/998 11/18722 0.452690939472095 0.742072023542797 NRP1 1 GO:0061303 cornea development in camera-type eye 1/998 11/18722 0.452690939472095 0.742072023542797 LIMK2 1 GO:0061314 Notch signaling involved in heart development 1/998 11/18722 0.452690939472095 0.742072023542797 GALNT11 1 GO:0070243 regulation of thymocyte apoptotic process 1/998 11/18722 0.452690939472095 0.742072023542797 EFNA1 1 GO:0070327 thyroid hormone transport 1/998 11/18722 0.452690939472095 0.742072023542797 SLC16A2 1 GO:0070601 centromeric sister chromatid cohesion 1/998 11/18722 0.452690939472095 0.742072023542797 CTNNB1 1 GO:0071044 histone mRNA catabolic process 1/998 11/18722 0.452690939472095 0.742072023542797 DCP2 1 GO:0071377 cellular response to glucagon stimulus 1/998 11/18722 0.452690939472095 0.742072023542797 ASS1 1 GO:0071888 macrophage apoptotic process 1/998 11/18722 0.452690939472095 0.742072023542797 CTSL 1 GO:0072110 glomerular mesangial cell proliferation 1/998 11/18722 0.452690939472095 0.742072023542797 BMP7 1 GO:0072173 metanephric tubule morphogenesis 1/998 11/18722 0.452690939472095 0.742072023542797 LGR4 1 GO:0072205 metanephric collecting duct development 1/998 11/18722 0.452690939472095 0.742072023542797 DLG5 1 GO:0075294 positive regulation by symbiont of entry into host 1/998 11/18722 0.452690939472095 0.742072023542797 P4HB 1 GO:0075733 intracellular transport of virus 1/998 11/18722 0.452690939472095 0.742072023542797 FMR1 1 GO:0086016 AV node cell action potential 1/998 11/18722 0.452690939472095 0.742072023542797 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/998 11/18722 0.452690939472095 0.742072023542797 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/998 11/18722 0.452690939472095 0.742072023542797 GJA5 1 GO:0090084 negative regulation of inclusion body assembly 1/998 11/18722 0.452690939472095 0.742072023542797 HSPA1B 1 GO:0090160 Golgi to lysosome transport 1/998 11/18722 0.452690939472095 0.742072023542797 CLN3 1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1/998 11/18722 0.452690939472095 0.742072023542797 DVL3 1 GO:0090394 negative regulation of excitatory postsynaptic potential 1/998 11/18722 0.452690939472095 0.742072023542797 S1PR2 1 GO:0097354 prenylation 1/998 11/18722 0.452690939472095 0.742072023542797 CHML 1 GO:0098792 xenophagy 1/998 11/18722 0.452690939472095 0.742072023542797 LGALS8 1 GO:0099022 vesicle tethering 1/998 11/18722 0.452690939472095 0.742072023542797 TRIP11 1 GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 1/998 11/18722 0.452690939472095 0.742072023542797 OPHN1 1 GO:0106049 regulation of cellular response to osmotic stress 1/998 11/18722 0.452690939472095 0.742072023542797 CLN3 1 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 ATP2B4 1 GO:1900222 negative regulation of amyloid-beta clearance 1/998 11/18722 0.452690939472095 0.742072023542797 LRPAP1 1 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 GSK3B 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/998 11/18722 0.452690939472095 0.742072023542797 N4BP2L2 1 GO:1902065 response to L-glutamate 1/998 11/18722 0.452690939472095 0.742072023542797 UFL1 1 GO:1902188 positive regulation of viral release from host cell 1/998 11/18722 0.452690939472095 0.742072023542797 DDB1 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/998 11/18722 0.452690939472095 0.742072023542797 BMP7 1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1/998 11/18722 0.452690939472095 0.742072023542797 HSPA1B 1 GO:1903299 regulation of hexokinase activity 1/998 11/18722 0.452690939472095 0.742072023542797 RANBP2 1 GO:1904321 response to forskolin 1/998 11/18722 0.452690939472095 0.742072023542797 GNAI1 1 GO:1904322 cellular response to forskolin 1/998 11/18722 0.452690939472095 0.742072023542797 GNAI1 1 GO:1904729 regulation of intestinal lipid absorption 1/998 11/18722 0.452690939472095 0.742072023542797 LPCAT3 1 GO:1905050 positive regulation of metallopeptidase activity 1/998 11/18722 0.452690939472095 0.742072023542797 CLDN4 1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/998 11/18722 0.452690939472095 0.742072023542797 TJP1 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/998 11/18722 0.452690939472095 0.742072023542797 LRP1 1 GO:2000392 regulation of lamellipodium morphogenesis 1/998 11/18722 0.452690939472095 0.742072023542797 KANK1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/998 11/18722 0.452690939472095 0.742072023542797 PKIB 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/998 11/18722 0.452690939472095 0.742072023542797 BMP7 1 GO:0042102 positive regulation of T cell proliferation 6/998 101/18722 0.453051886535904 0.742197646565408 CD46/TFRC/CD55/CD24/IL6ST/PNP 6 GO:0098869 cellular oxidant detoxification 6/998 101/18722 0.453051886535904 0.742197646565408 BMP7/MGST3/PRDX4/GPX8/SOD3/NFE2L2 6 GO:0001935 endothelial cell proliferation 11/998 193/18722 0.454078262461369 0.743645736609413 NRP2/NRP1/GJA1/NR2F2/DLG1/NF1/TGFBR1/PPARG/PTPRM/MMP14/EMC10 11 GO:0000724 double-strand break repair via homologous recombination 8/998 138/18722 0.45581005362986 0.746013884013009 PARP1/FUS/SFPQ/SETD2/RAD21/RIF1/NIPBL/YY1 8 GO:0055076 transition metal ion homeostasis 8/998 138/18722 0.45581005362986 0.746013884013009 APP/TFRC/SLC39A10/SLC40A1/EIF2AK1/SLC39A7/ACO1/SLC30A7 8 GO:0035418 protein localization to synapse 4/998 65/18722 0.458684439116994 0.750247950072001 DAG1/DLG1/CLSTN1/NSG1 4 GO:0043489 RNA stabilization 4/998 65/18722 0.458684439116994 0.750247950072001 FUS/MAPK14/DHX36/HNRNPU 4 GO:0032411 positive regulation of transporter activity 7/998 120/18722 0.459045353245056 0.750603128497474 TCAF1/AKAP9/ANK3/DMD/SLC9A1/ACTN4/ABCB1 7 GO:0001754 eye photoreceptor cell differentiation 3/998 47/18722 0.461256757261816 0.75101468976799 MYO7A/TUG1/PRKCI 3 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 3/998 47/18722 0.461256757261816 0.75101468976799 MME/ADRB1/ENPEP 3 GO:0006998 nuclear envelope organization 3/998 47/18722 0.461256757261816 0.75101468976799 REEP3/SUN1/LMNA 3 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 3/998 47/18722 0.461256757261816 0.75101468976799 SPPL2A/SPPL2B/HSPA1B 3 GO:0048512 circadian behavior 3/998 47/18722 0.461256757261816 0.75101468976799 ADRB1/ZFHX3/GPR157 3 GO:0061001 regulation of dendritic spine morphogenesis 3/998 47/18722 0.461256757261816 0.75101468976799 PPP1R9A/EFNA1/DHX36 3 GO:0034765 regulation of ion transmembrane transport 27/998 491/18722 0.462095467969126 0.75101468976799 APP/TCAF1/AHNAK/UTRN/AKAP9/ITGB1/DLG1/SLC43A2/GJA5/FXYD3/ANO6/ANK3/ARL6IP5/ATP2B4/KCNN4/DMD/SLC9A1/TSPAN13/HOMER1/FMR1/NEDD4/ACTN4/AHCYL1/GOPC/ABCB1/STOM/GPD1L 27 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 2/998 29/18722 0.462461640989099 0.75101468976799 AGO2/TNRC6A 2 GO:0003309 type B pancreatic cell differentiation 2/998 29/18722 0.462461640989099 0.75101468976799 CDK6/GSK3B 2 GO:0005979 regulation of glycogen biosynthetic process 2/998 29/18722 0.462461640989099 0.75101468976799 SORBS1/GSK3B 2 GO:0010962 regulation of glucan biosynthetic process 2/998 29/18722 0.462461640989099 0.75101468976799 SORBS1/GSK3B 2 GO:0015701 bicarbonate transport 2/998 29/18722 0.462461640989099 0.75101468976799 SLC26A2/CYB5R1 2 GO:0021591 ventricular system development 2/998 29/18722 0.462461640989099 0.75101468976799 SEMA6D/CDK6 2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2/998 29/18722 0.462461640989099 0.75101468976799 EGFR/CCND1 2 GO:0048265 response to pain 2/998 29/18722 0.462461640989099 0.75101468976799 VWA1/P2RX4 2 GO:0050686 negative regulation of mRNA processing 2/998 29/18722 0.462461640989099 0.75101468976799 ZC3H14/SRSF4 2 GO:0051654 establishment of mitochondrion localization 2/998 29/18722 0.462461640989099 0.75101468976799 LRPPRC/ARMCX3 2 GO:0070198 protein localization to chromosome, telomeric region 2/998 29/18722 0.462461640989099 0.75101468976799 ATRX/TNKS2 2 GO:0070979 protein K11-linked ubiquitination 2/998 29/18722 0.462461640989099 0.75101468976799 UBE2H/ANAPC5 2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/998 29/18722 0.462461640989099 0.75101468976799 USP47/BCL2 2 GO:2000406 positive regulation of T cell migration 2/998 29/18722 0.462461640989099 0.75101468976799 APP/DOCK8 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/998 29/18722 0.462461640989099 0.75101468976799 PRKDC/RIF1 2 GO:0140014 mitotic nuclear division 16/998 287/18722 0.463519084632235 0.751916211795023 BMP7/LRP5/EML4/OBSL1/ATRX/TPR/REEP3/RAD21/EPS8/ANAPC5/GOLGA2/PDS5A/HSPA1B/NIPBL/STAG1/HNRNPU 16 GO:0001505 regulation of neurotransmitter levels 12/998 213/18722 0.464290459975855 0.751916211795023 SLC6A4/ITGB1/SLC38A1/PPP1R9A/SYT7/CLN3/FMR1/SLC1A3/ATP2A2/GSK3B/MCTP2/SLC29A1 12 GO:0050728 negative regulation of inflammatory response 10/998 176/18722 0.464339588556344 0.751916211795023 SERPINF1/ASH1L/ISL1/LPCAT3/YES1/PPARG/MAPK14/GATA3/PLK2/VPS35 10 GO:0006405 RNA export from nucleus 5/998 84/18722 0.466329092398505 0.751916211795023 TPR/SETD2/AGFG1/PABPN1/HNRNPA2B1 5 GO:0010921 regulation of phosphatase activity 5/998 84/18722 0.466329092398505 0.751916211795023 HSP90B1/SLC39A10/BOD1L1/GSK3B/PPP6R2 5 GO:0042310 vasoconstriction 5/998 84/18722 0.466329092398505 0.751916211795023 EGFR/ATP2B1/SLC6A4/GJA1/GJA5 5 GO:0061157 mRNA destabilization 5/998 84/18722 0.466329092398505 0.751916211795023 PUM1/DCP2/DHX36/AGO2/TNRC6A 5 GO:0051251 positive regulation of lymphocyte activation 20/998 362/18722 0.467371286397415 0.751916211795023 CD46/DPP4/TFRC/SLC39A10/CD55/CD24/CD47/PRKDC/IL6ST/VAV3/HSPD1/GLI3/DOCK8/YES1/RIF1/MMP14/GATA3/BCL2/FLOT2/PNP 20 GO:0030073 insulin secretion 11/998 195/18722 0.467776936526826 0.751916211795023 DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ISL1/SYT7/SLC16A1/TCF7L2 11 GO:0018393 internal peptidyl-lysine acetylation 9/998 158/18722 0.468007824619246 0.751916211795023 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/PHF20/GATA3/USP22/BRD8 9 GO:0006302 double-strand break repair 14/998 251/18722 0.470016340088231 0.751916211795023 PARP1/FUS/PRKDC/RAD50/SFPQ/SETD2/UVRAG/RAD21/VCP/RIF1/DDX1/UBR5/NIPBL/YY1 14 GO:0019229 regulation of vasoconstriction 4/998 66/18722 0.470520231068155 0.751916211795023 EGFR/ATP2B1/GJA1/GJA5 4 GO:1905953 negative regulation of lipid localization 4/998 66/18722 0.470520231068155 0.751916211795023 ITGAV/ABCA1/PLA2R1/PPARG 4 GO:0030148 sphingolipid biosynthetic process 6/998 103/18722 0.47196839807897 0.751916211795023 DEGS1/ORMDL1/HACD3/PLPP3/SPTLC3/SGPP1 6 GO:0030593 neutrophil chemotaxis 6/998 103/18722 0.47196839807897 0.751916211795023 CSF3R/DPP4/VAV3/BSG/JAM3/PPIB 6 GO:0032760 positive regulation of tumor necrosis factor production 6/998 103/18722 0.47196839807897 0.751916211795023 APP/HSPD1/ISL1/TLR3/FZD5/HDAC2 6 GO:0000725 recombinational repair 8/998 140/18722 0.472000747598956 0.751916211795023 PARP1/FUS/SFPQ/SETD2/RAD21/RIF1/NIPBL/YY1 8 GO:0007292 female gamete generation 8/998 140/18722 0.472000747598956 0.751916211795023 LGR5/ADAMTS1/DIAPH2/ZFX/HEXB/USP9X/CTNNB1/BCL2 8 GO:0006006 glucose metabolic process 11/998 196/18722 0.474605676633539 0.751916211795023 DDB1/LRP5/SLC35B4/SORBS1/MAPK14/FAM3C/GAA/RANBP2/GSK3B/PMAIP1/PHLDA2 11 GO:0022408 negative regulation of cell-cell adhesion 11/998 196/18722 0.474605676633539 0.751916211795023 CDH1/DLG5/SPINT2/DLG1/GLI3/PAWR/SWAP70/MIA3/RDX/PTK2/ASS1 11 GO:0035036 sperm-egg recognition 3/998 48/18722 0.475194467629865 0.751916211795023 SPESP1/FOLR1/B4GALT1 3 GO:0045839 negative regulation of mitotic nuclear division 3/998 48/18722 0.475194467629865 0.751916211795023 BMP7/TPR/RAD21 3 GO:0045912 negative regulation of carbohydrate metabolic process 3/998 48/18722 0.475194467629865 0.751916211795023 CLTC/FAM3C/GSK3B 3 GO:0120009 intermembrane lipid transfer 3/998 48/18722 0.475194467629865 0.751916211795023 ABCA1/PLEKHA8/TTPA 3 GO:1905710 positive regulation of membrane permeability 3/998 48/18722 0.475194467629865 0.751916211795023 SLC9A1/JAM3/GSK3B 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/998 48/18722 0.475194467629865 0.751916211795023 PDIA3/PMAIP1/CTNNA1 3 GO:0031109 microtubule polymerization or depolymerization 7/998 122/18722 0.476406887780857 0.751916211795023 MET/CLIP1/AKAP9/CAMSAP2/GOLGA2/OCLN/HSPA1B 7 GO:0010507 negative regulation of autophagy 5/998 85/18722 0.476731418211704 0.751916211795023 MET/EIF4G1/BCL2/GOLGA2/TAB3 5 GO:0006109 regulation of carbohydrate metabolic process 10/998 178/18722 0.478691230046306 0.751916211795023 APP/DDB1/CLTC/SLC35B4/SORBS1/FAM3C/RANBP2/GSK3B/PMAIP1/PHLDA2 10 GO:0035296 regulation of tube diameter 8/998 141/18722 0.480055766856644 0.751916211795023 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/GJA5/EXT2/SOD3 8 GO:0050921 positive regulation of chemotaxis 8/998 141/18722 0.480055766856644 0.751916211795023 MET/NRP1/ANO6/CALR/TPBG/P2RX4/SWAP70/PTK2 8 GO:0097746 blood vessel diameter maintenance 8/998 141/18722 0.480055766856644 0.751916211795023 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/GJA5/EXT2/SOD3 8 GO:0006099 tricarboxylic acid cycle 2/998 30/18722 0.480253209388492 0.751916211795023 IDH1/ACO1 2 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 2/998 30/18722 0.480253209388492 0.751916211795023 DICER1/BLCAP 2 GO:0007176 regulation of epidermal growth factor-activated receptor activity 2/998 30/18722 0.480253209388492 0.751916211795023 APP/ERRFI1 2 GO:0010453 regulation of cell fate commitment 2/998 30/18722 0.480253209388492 0.751916211795023 LMO4/ESRP1 2 GO:0019674 NAD metabolic process 2/998 30/18722 0.480253209388492 0.751916211795023 QPRT/GPD1L 2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 2/998 30/18722 0.480253209388492 0.751916211795023 CTSL/CTSV 2 GO:0033137 negative regulation of peptidyl-serine phosphorylation 2/998 30/18722 0.480253209388492 0.751916211795023 DMD/GPD1L 2 GO:0034694 response to prostaglandin 2/998 30/18722 0.480253209388492 0.751916211795023 TGFBR3/YY1 2 GO:0044030 regulation of DNA methylation 2/998 30/18722 0.480253209388492 0.751916211795023 PARP1/MPHOSPH8 2 GO:0048147 negative regulation of fibroblast proliferation 2/998 30/18722 0.480253209388492 0.751916211795023 NF1/PAWR 2 GO:0048799 animal organ maturation 2/998 30/18722 0.480253209388492 0.751916211795023 PLXNB1/GATA3 2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 2/998 30/18722 0.480253209388492 0.751916211795023 PAWR/EZR 2 GO:0060351 cartilage development involved in endochondral bone morphogenesis 2/998 30/18722 0.480253209388492 0.751916211795023 TRIP11/SERPINH1 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/998 30/18722 0.480253209388492 0.751916211795023 GALNT11/CTNNB1 2 GO:0070498 interleukin-1-mediated signaling pathway 2/998 30/18722 0.480253209388492 0.751916211795023 RPS6KA5/OTUD4 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/998 30/18722 0.480253209388492 0.751916211795023 TMEM59/AGO2 2 GO:0007059 chromosome segregation 19/998 346/18722 0.480707213749258 0.751916211795023 EML4/DYNC1H1/ATRX/TPR/USP9X/PUM1/SFPQ/TLK1/TOP2B/UVRAG/RAD21/CTNNB1/SUN1/WAPL/ANAPC5/PDS5A/NIPBL/STAG1/HNRNPU 19 GO:0022600 digestive system process 6/998 104/18722 0.481358473155633 0.751916211795023 LIMA1/KCNN4/LPCAT3/EZR/SLC22A5/ACO1 6 GO:0045621 positive regulation of lymphocyte differentiation 6/998 104/18722 0.481358473155633 0.751916211795023 CD46/PRKDC/GLI3/MMP14/GATA3/PNP 6 GO:0000012 single strand break repair 1/998 12/18722 0.481883096086218 0.751916211795023 PARP1 1 GO:0001821 histamine secretion 1/998 12/18722 0.481883096086218 0.751916211795023 SNX4 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/998 12/18722 0.481883096086218 0.751916211795023 NAV2 1 GO:0002024 diet induced thermogenesis 1/998 12/18722 0.481883096086218 0.751916211795023 ADRB1 1 GO:0002328 pro-B cell differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 PRKDC 1 GO:0002424 T cell mediated immune response to tumor cell 1/998 12/18722 0.481883096086218 0.751916211795023 HSPD1 1 GO:0002674 negative regulation of acute inflammatory response 1/998 12/18722 0.481883096086218 0.751916211795023 ASH1L 1 GO:0002903 negative regulation of B cell apoptotic process 1/998 12/18722 0.481883096086218 0.751916211795023 SLC39A10 1 GO:0003306 Wnt signaling pathway involved in heart development 1/998 12/18722 0.481883096086218 0.751916211795023 CTNNB1 1 GO:0006534 cysteine metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 CDO1 1 GO:0006563 L-serine metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 SERINC3 1 GO:0006703 estrogen biosynthetic process 1/998 12/18722 0.481883096086218 0.751916211795023 HSD17B1 1 GO:0007320 insemination 1/998 12/18722 0.481883096086218 0.751916211795023 SLC6A4 1 GO:0007614 short-term memory 1/998 12/18722 0.481883096086218 0.751916211795023 SERPINF1 1 GO:0009086 methionine biosynthetic process 1/998 12/18722 0.481883096086218 0.751916211795023 MTR 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/998 12/18722 0.481883096086218 0.751916211795023 LRP1 1 GO:0016554 cytidine to uridine editing 1/998 12/18722 0.481883096086218 0.751916211795023 RBM47 1 GO:0019627 urea metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 ASS1 1 GO:0021527 spinal cord association neuron differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 LMO4 1 GO:0021670 lateral ventricle development 1/998 12/18722 0.481883096086218 0.751916211795023 CDK6 1 GO:0021781 glial cell fate commitment 1/998 12/18722 0.481883096086218 0.751916211795023 CTNNB1 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/998 12/18722 0.481883096086218 0.751916211795023 SLC6A4 1 GO:0031223 auditory behavior 1/998 12/18722 0.481883096086218 0.751916211795023 SLC1A3 1 GO:0031953 negative regulation of protein autophosphorylation 1/998 12/18722 0.481883096086218 0.751916211795023 ERRFI1 1 GO:0032306 regulation of prostaglandin secretion 1/998 12/18722 0.481883096086218 0.751916211795023 P2RX4 1 GO:0032536 regulation of cell projection size 1/998 12/18722 0.481883096086218 0.751916211795023 EZR 1 GO:0032736 positive regulation of interleukin-13 production 1/998 12/18722 0.481883096086218 0.751916211795023 GATA3 1 GO:0032908 regulation of transforming growth factor beta1 production 1/998 12/18722 0.481883096086218 0.751916211795023 CD2AP 1 GO:0033182 regulation of histone ubiquitination 1/998 12/18722 0.481883096086218 0.751916211795023 UBR5 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/998 12/18722 0.481883096086218 0.751916211795023 CROT 1 GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/998 12/18722 0.481883096086218 0.751916211795023 DNMT1 1 GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/998 12/18722 0.481883096086218 0.751916211795023 CD55 1 GO:0038180 nerve growth factor signaling pathway 1/998 12/18722 0.481883096086218 0.751916211795023 KIDINS220 1 GO:0042762 regulation of sulfur metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 NFE2L2 1 GO:0043380 regulation of memory T cell differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 CD46 1 GO:0043383 negative T cell selection 1/998 12/18722 0.481883096086218 0.751916211795023 GLI3 1 GO:0045117 azole transmembrane transport 1/998 12/18722 0.481883096086218 0.751916211795023 SLC19A3 1 GO:0045605 negative regulation of epidermal cell differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 TP63 1 GO:0045683 negative regulation of epidermis development 1/998 12/18722 0.481883096086218 0.751916211795023 TP63 1 GO:0046051 UTP metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 AK3 1 GO:0046185 aldehyde catabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 ADH5 1 GO:0046322 negative regulation of fatty acid oxidation 1/998 12/18722 0.481883096086218 0.751916211795023 ACADVL 1 GO:0046541 saliva secretion 1/998 12/18722 0.481883096086218 0.751916211795023 KCNN4 1 GO:0048548 regulation of pinocytosis 1/998 12/18722 0.481883096086218 0.751916211795023 CLN3 1 GO:0048742 regulation of skeletal muscle fiber development 1/998 12/18722 0.481883096086218 0.751916211795023 BCL2 1 GO:0048934 peripheral nervous system neuron differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/998 12/18722 0.481883096086218 0.751916211795023 ISL1 1 GO:0051001 negative regulation of nitric-oxide synthase activity 1/998 12/18722 0.481883096086218 0.751916211795023 ATP2B4 1 GO:0051013 microtubule severing 1/998 12/18722 0.481883096086218 0.751916211795023 FIGN 1 GO:0051639 actin filament network formation 1/998 12/18722 0.481883096086218 0.751916211795023 COBL 1 GO:0060009 Sertoli cell development 1/998 12/18722 0.481883096086218 0.751916211795023 ATRX 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/998 12/18722 0.481883096086218 0.751916211795023 GLI3 1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development 1/998 12/18722 0.481883096086218 0.751916211795023 YY1 1 GO:0061517 macrophage proliferation 1/998 12/18722 0.481883096086218 0.751916211795023 PTK2 1 GO:0070170 regulation of tooth mineralization 1/998 12/18722 0.481883096086218 0.751916211795023 TFAP2A 1 GO:0070572 positive regulation of neuron projection regeneration 1/998 12/18722 0.481883096086218 0.751916211795023 LRP1 1 GO:0071107 response to parathyroid hormone 1/998 12/18722 0.481883096086218 0.751916211795023 GJA1 1 GO:0071257 cellular response to electrical stimulus 1/998 12/18722 0.481883096086218 0.751916211795023 SLC9A1 1 GO:0071468 cellular response to acidic pH 1/998 12/18722 0.481883096086218 0.751916211795023 SLC9A1 1 GO:0071712 ER-associated misfolded protein catabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 VCP 1 GO:0071941 nitrogen cycle metabolic process 1/998 12/18722 0.481883096086218 0.751916211795023 ASS1 1 GO:0072376 protein activation cascade 1/998 12/18722 0.481883096086218 0.751916211795023 FBLN1 1 GO:0072584 caveolin-mediated endocytosis 1/998 12/18722 0.481883096086218 0.751916211795023 CLN3 1 GO:0086067 AV node cell to bundle of His cell communication 1/998 12/18722 0.481883096086218 0.751916211795023 GJA5 1 GO:0090177 establishment of planar polarity involved in neural tube closure 1/998 12/18722 0.481883096086218 0.751916211795023 DVL3 1 GO:0090677 reversible differentiation 1/998 12/18722 0.481883096086218 0.751916211795023 DNMT1 1 GO:0097152 mesenchymal cell apoptotic process 1/998 12/18722 0.481883096086218 0.751916211795023 BMP7 1 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/998 12/18722 0.481883096086218 0.751916211795023 MIA3 1 GO:1903332 regulation of protein folding 1/998 12/18722 0.481883096086218 0.751916211795023 HSPA5 1 GO:1903441 protein localization to ciliary membrane 1/998 12/18722 0.481883096086218 0.751916211795023 RABEP1 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/998 12/18722 0.481883096086218 0.751916211795023 EGFR 1 GO:1904748 regulation of apoptotic process involved in development 1/998 12/18722 0.481883096086218 0.751916211795023 BMP7 1 GO:1905245 regulation of aspartic-type peptidase activity 1/998 12/18722 0.481883096086218 0.751916211795023 EFNA1 1 GO:1990034 calcium ion export across plasma membrane 1/998 12/18722 0.481883096086218 0.751916211795023 ATP2B1 1 GO:2000035 regulation of stem cell division 1/998 12/18722 0.481883096086218 0.751916211795023 NCOA3 1 GO:2000105 positive regulation of DNA-dependent DNA replication 1/998 12/18722 0.481883096086218 0.751916211795023 ATRX 1 GO:2000303 regulation of ceramide biosynthetic process 1/998 12/18722 0.481883096086218 0.751916211795023 ORMDL1 1 GO:2000508 regulation of dendritic cell chemotaxis 1/998 12/18722 0.481883096086218 0.751916211795023 CALR 1 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/998 12/18722 0.481883096086218 0.751916211795023 CD55 1 GO:2001204 regulation of osteoclast development 1/998 12/18722 0.481883096086218 0.751916211795023 FBN1 1 GO:0050435 amyloid-beta metabolic process 4/998 67/18722 0.482258986539932 0.752277911181651 MME/EFNA1/NCSTN/RTN4 4 GO:0006475 internal protein amino acid acetylation 9/998 160/18722 0.483150527383506 0.753218543884529 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/PHF20/GATA3/USP22/BRD8 9 GO:0043271 negative regulation of ion transport 9/998 160/18722 0.483150527383506 0.753218543884529 GABRE/SLC43A2/ANK3/ARL6IP5/FMR1/NEDD4/PLA2R1/GOPC/BCL2 9 GO:0051090 regulation of DNA-binding transcription factor activity 24/998 440/18722 0.483912059315341 0.754180555726984 APP/BMP7/TFRC/LRP5/PLPP3/TLR3/RPS6KA5/ERC1/UFL1/PRKCI/PPARG/CREBZF/KRAS/PURA/EIF2AK4/FZD6/ARID5B/CTNNB1/TCF7L2/HSPA1B/FLOT2/ANXA3/MAP3K13/HDAC2 24 GO:0010950 positive regulation of endopeptidase activity 10/998 179/18722 0.48583735168546 0.756955181483076 ASPH/PERP/ARL6IP5/HSPD1/EFNA1/NCSTN/PPARG/BCAP31/VCP/PMAIP1 10 GO:0046928 regulation of neurotransmitter secretion 5/998 86/18722 0.487065821443222 0.758642796466307 PPP1R9A/FMR1/ATP2A2/GSK3B/MCTP2 5 GO:0035150 regulation of tube size 8/998 142/18722 0.488079977902929 0.759107068038589 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/GJA5/EXT2/SOD3 8 GO:0006376 mRNA splice site selection 3/998 49/18722 0.488963238807465 0.759107068038589 SF1/SRSF5/LUC7L3 3 GO:0006778 porphyrin-containing compound metabolic process 3/998 49/18722 0.488963238807465 0.759107068038589 EIF2AK1/NFE2L1/ALAD 3 GO:0007622 rhythmic behavior 3/998 49/18722 0.488963238807465 0.759107068038589 ADRB1/ZFHX3/GPR157 3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 3/998 49/18722 0.488963238807465 0.759107068038589 BMP7/TGFBR1/PPARG 3 GO:0021515 cell differentiation in spinal cord 3/998 49/18722 0.488963238807465 0.759107068038589 LMO4/ISL1/GLI3 3 GO:0021695 cerebellar cortex development 3/998 49/18722 0.488963238807465 0.759107068038589 HSPA5/RERE/OPHN1 3 GO:0030225 macrophage differentiation 3/998 49/18722 0.488963238807465 0.759107068038589 APP/PARP1/EIF2AK1 3 GO:0043457 regulation of cellular respiration 3/998 49/18722 0.488963238807465 0.759107068038589 IL10RB/OPN3/VCP 3 GO:0048168 regulation of neuronal synaptic plasticity 3/998 49/18722 0.488963238807465 0.759107068038589 APP/CLN3/KRAS 3 GO:1904894 positive regulation of receptor signaling pathway via STAT 3/998 49/18722 0.488963238807465 0.759107068038589 PRLR/IL10RB/OCIAD1 3 GO:0050863 regulation of T cell activation 18/998 329/18722 0.489434670338276 0.759613083780065 CD46/DPP4/TFRC/DLG5/DLG1/CD55/CD24/CD47/IL6ST/HSPD1/GLI3/DOCK8/PAWR/YES1/CTNNB1/GATA3/FLOT2/PNP 18 GO:0046395 carboxylic acid catabolic process 13/998 236/18722 0.492275987920864 0.763795819594303 GLDC/SLC27A2/ATP2B4/HADHA/QPRT/CROT/ECHDC2/ACADVL/ECI2/CDO1/CPT2/ECHDC1/ETFA 13 GO:0010508 positive regulation of autophagy 7/998 124/18722 0.493619121657159 0.76565223831611 UFL1/TMEM59/PIK3CB/UVRAG/PLK2/GSK3B/ATF6 7 GO:0050727 regulation of inflammatory response 21/998 386/18722 0.493837964000076 0.76576418474737 EGFR/APP/SERPINF1/BRD4/TGM2/CD47/IL6ST/HSPD1/ASH1L/ISL1/LPCAT3/TLR3/UFL1/YES1/PPARG/MAPK14/GATA3/PLK2/PDCD4/SNX4/VPS35 21 GO:0042445 hormone metabolic process 12/998 218/18722 0.496815708896555 0.766849899373326 MME/CTSL/ENPEP/HSD17B1/SLC16A2/PLEKHA1/TCF7L2/GCNT4/GATA3/ALDH1A3/PCSK7/STC2 12 GO:0016101 diterpenoid metabolic process 5/998 87/18722 0.497326822544142 0.766849899373326 EGFR/LRP2/LRP1/ADH5/ALDH1A3 5 GO:0051262 protein tetramerization 5/998 87/18722 0.497326822544142 0.766849899373326 TP63/HOMER1/TRPM7/GOLGA2/ALDH1A3 5 GO:0061014 positive regulation of mRNA catabolic process 5/998 87/18722 0.497326822544142 0.766849899373326 PUM1/DCP2/DHX36/AGO2/TNRC6A 5 GO:0006301 postreplication repair 2/998 31/18722 0.497677569121716 0.766849899373326 USP10/VCP 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/998 31/18722 0.497677569121716 0.766849899373326 NFE2L1/ALAD 2 GO:0016577 histone demethylation 2/998 31/18722 0.497677569121716 0.766849899373326 KDM5B/KDM4B 2 GO:0030212 hyaluronan metabolic process 2/998 31/18722 0.497677569121716 0.766849899373326 ITIH5/CLTC 2 GO:0032509 endosome transport via multivesicular body sorting pathway 2/998 31/18722 0.497677569121716 0.766849899373326 LEPROT/VCP 2 GO:0033014 tetrapyrrole biosynthetic process 2/998 31/18722 0.497677569121716 0.766849899373326 NFE2L1/ALAD 2 GO:0033238 regulation of cellular amine metabolic process 2/998 31/18722 0.497677569121716 0.766849899373326 ATP2B4/CLN3 2 GO:0042133 neurotransmitter metabolic process 2/998 31/18722 0.497677569121716 0.766849899373326 SLC6A4/CLN3 2 GO:0043171 peptide catabolic process 2/998 31/18722 0.497677569121716 0.766849899373326 ENPEP/NPEPPS 2 GO:0055075 potassium ion homeostasis 2/998 31/18722 0.497677569121716 0.766849899373326 SLC12A9/ATP6V1B1 2 GO:0060055 angiogenesis involved in wound healing 2/998 31/18722 0.497677569121716 0.766849899373326 DAG1/B4GALT1 2 GO:0070528 protein kinase C signaling 2/998 31/18722 0.497677569121716 0.766849899373326 ADGRG1/GPD1L 2 GO:0097106 postsynaptic density organization 2/998 31/18722 0.497677569121716 0.766849899373326 DLG1/OPHN1 2 GO:2000144 positive regulation of DNA-templated transcription, initiation 2/998 31/18722 0.497677569121716 0.766849899373326 BCLAF1/DHX36 2 GO:0021953 central nervous system neuron differentiation 9/998 162/18722 0.498188858192405 0.766849899373326 NRP2/NRP1/LMO4/ISL1/GLI3/MYCBP2/HSP90AA1/FGFR2/OPHN1 9 GO:0034250 positive regulation of cellular amide metabolic process 9/998 162/18722 0.498188858192405 0.766849899373326 PRKDC/EFNA1/EIF4G1/FMR1/EIF2AK4/LARP4/DHX36/AGO2/NFE2L2 9 GO:1901617 organic hydroxy compound biosynthetic process 13/998 237/18722 0.498484485308821 0.766849899373326 SLC27A2/ISYNA1/OPN3/LPCAT3/CYB5R1/HSD17B1/MBTPS1/DHCR24/OSBPL9/SPTLC3/FDFT1/GATA3/SQLE 13 GO:0035821 modulation of process of other organism 6/998 106/18722 0.499980383887035 0.766849899373326 DAG1/ANO6/FMR1/EIF2AK4/STOM/PPIB 6 GO:0099565 chemical synaptic transmission, postsynaptic 6/998 106/18722 0.499980383887035 0.766849899373326 APP/PPP1R9A/S1PR2/P2RX4/GSK3B/SLC29A1 6 GO:1903707 negative regulation of hemopoiesis 6/998 106/18722 0.499980383887035 0.766849899373326 FBN1/CDK6/GLI3/TLR3/CTNNB1/HSPA9 6 GO:0099003 vesicle-mediated transport in synapse 11/998 200/18722 0.501740100821828 0.766849899373326 CANX/SYT7/STON1/KIAA1109/FMR1/CLSTN1/CTNNB1/ATP2A2/GSK3B/OPHN1/NSG1 11 GO:0071621 granulocyte chemotaxis 7/998 125/18722 0.502160631825472 0.766849899373326 CSF3R/DPP4/VAV3/BSG/JAM3/PTK2/PPIB 7 GO:0071825 protein-lipid complex subunit organization 3/998 50/18722 0.502553019144535 0.766849899373326 ABCA1/LPCAT3/ACSL3 3 GO:0099054 presynapse assembly 3/998 50/18722 0.502553019144535 0.766849899373326 APP/EIF4G1/VPS35 3 GO:1901570 fatty acid derivative biosynthetic process 3/998 50/18722 0.502553019144535 0.766849899373326 ACSL3/FAR1/TECR 3 GO:0034655 nucleobase-containing compound catabolic process 22/998 407/18722 0.504665212945142 0.766849899373326 KCNQ1OT1/NUDT4/LIN28B/FUS/SND1/TTC37/PUM1/LRPPRC/DCP2/SMPDL3A/FMR1/DICER1/VCP/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/PNP/HNRNPU 22 GO:0051966 regulation of synaptic transmission, glutamatergic 4/998 69/18722 0.505415816234746 0.766849899373326 EGFR/CLN3/HOMER1/OPHN1 4 GO:0070192 chromosome organization involved in meiotic cell cycle 4/998 69/18722 0.505415816234746 0.766849899373326 RAD50/ATRX/RAD21/SUN1 4 GO:0006473 protein acetylation 11/998 201/18722 0.508469650238342 0.766849899373326 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/PHF20/GATA3/USP22/GSK3B/BRD8/HDAC2 11 GO:0000018 regulation of DNA recombination 6/998 107/18722 0.509203958822118 0.766849899373326 TFRC/PARP1/FUS/RAD50/SETD2/RIF1 6 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/998 107/18722 0.509203958822118 0.766849899373326 TFRC/CD55/HSPD1/RIF1/FZD5/GATA3 6 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 6/998 107/18722 0.509203958822118 0.766849899373326 APP/HSPD1/ISL1/TLR3/FZD5/HDAC2 6 GO:0001886 endothelial cell morphogenesis 1/998 13/18722 0.509519689891988 0.766849899373326 MET 1 GO:0002551 mast cell chemotaxis 1/998 13/18722 0.509519689891988 0.766849899373326 SWAP70 1 GO:0002638 negative regulation of immunoglobulin production 1/998 13/18722 0.509519689891988 0.766849899373326 PRKDC 1 GO:0003222 ventricular trabecula myocardium morphogenesis 1/998 13/18722 0.509519689891988 0.766849899373326 TGFBR1 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/998 13/18722 0.509519689891988 0.766849899373326 CTNNB1 1 GO:0006995 cellular response to nitrogen starvation 1/998 13/18722 0.509519689891988 0.766849899373326 GABARAPL1 1 GO:0008298 intracellular mRNA localization 1/998 13/18722 0.509519689891988 0.766849899373326 DHX36 1 GO:0009143 nucleoside triphosphate catabolic process 1/998 13/18722 0.509519689891988 0.766849899373326 SMPDL3A 1 GO:0009650 UV protection 1/998 13/18722 0.509519689891988 0.766849899373326 SDF4 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/998 13/18722 0.509519689891988 0.766849899373326 PAXBP1 1 GO:0015791 polyol transport 1/998 13/18722 0.509519689891988 0.766849899373326 SLC5A3 1 GO:0016024 CDP-diacylglycerol biosynthetic process 1/998 13/18722 0.509519689891988 0.766849899373326 CDS1 1 GO:0016078 tRNA catabolic process 1/998 13/18722 0.509519689891988 0.766849899373326 DICER1 1 GO:0016322 neuron remodeling 1/998 13/18722 0.509519689891988 0.766849899373326 APP 1 GO:0021681 cerebellar granular layer development 1/998 13/18722 0.509519689891988 0.766849899373326 OPHN1 1 GO:0021859 pyramidal neuron differentiation 1/998 13/18722 0.509519689891988 0.766849899373326 FGFR2 1 GO:0032042 mitochondrial DNA metabolic process 1/998 13/18722 0.509519689891988 0.766849899373326 PARP1 1 GO:0032252 secretory granule localization 1/998 13/18722 0.509519689891988 0.766849899373326 USO1 1 GO:0032352 positive regulation of hormone metabolic process 1/998 13/18722 0.509519689891988 0.766849899373326 GATA3 1 GO:0032905 transforming growth factor beta1 production 1/998 13/18722 0.509519689891988 0.766849899373326 CD2AP 1 GO:0033262 regulation of nuclear cell cycle DNA replication 1/998 13/18722 0.509519689891988 0.766849899373326 ATRX 1 GO:0033700 phospholipid efflux 1/998 13/18722 0.509519689891988 0.766849899373326 ABCA1 1 GO:0035745 T-helper 2 cell cytokine production 1/998 13/18722 0.509519689891988 0.766849899373326 GATA3 1 GO:0035845 photoreceptor cell outer segment organization 1/998 13/18722 0.509519689891988 0.766849899373326 AHI1 1 GO:0042308 negative regulation of protein import into nucleus 1/998 13/18722 0.509519689891988 0.766849899373326 FERMT1 1 GO:0042541 hemoglobin biosynthetic process 1/998 13/18722 0.509519689891988 0.766849899373326 EIF2AK1 1 GO:0042769 DNA damage response, detection of DNA damage 1/998 13/18722 0.509519689891988 0.766849899373326 PARP1 1 GO:0043247 telomere maintenance in response to DNA damage 1/998 13/18722 0.509519689891988 0.766849899373326 RIF1 1 GO:0043379 memory T cell differentiation 1/998 13/18722 0.509519689891988 0.766849899373326 CD46 1 GO:0043562 cellular response to nitrogen levels 1/998 13/18722 0.509519689891988 0.766849899373326 GABARAPL1 1 GO:0043928 exonucleolytic catabolism of deadenylated mRNA 1/998 13/18722 0.509519689891988 0.766849899373326 DCP2 1 GO:0044090 positive regulation of vacuole organization 1/998 13/18722 0.509519689891988 0.766849899373326 ANXA2 1 GO:0046512 sphingosine biosynthetic process 1/998 13/18722 0.509519689891988 0.766849899373326 SPTLC3 1 GO:0046520 sphingoid biosynthetic process 1/998 13/18722 0.509519689891988 0.766849899373326 SPTLC3 1 GO:0048070 regulation of developmental pigmentation 1/998 13/18722 0.509519689891988 0.766849899373326 BCL2 1 GO:0048207 vesicle targeting, rough ER to cis-Golgi 1/998 13/18722 0.509519689891988 0.766849899373326 TFG 1 GO:0048208 COPII vesicle coating 1/998 13/18722 0.509519689891988 0.766849899373326 TFG 1 GO:0048711 positive regulation of astrocyte differentiation 1/998 13/18722 0.509519689891988 0.766849899373326 IL6ST 1 GO:0051451 myoblast migration 1/998 13/18722 0.509519689891988 0.766849899373326 NET1 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/998 13/18722 0.509519689891988 0.766849899373326 HNRNPU 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/998 13/18722 0.509519689891988 0.766849899373326 NFE2L2 1 GO:0061469 regulation of type B pancreatic cell proliferation 1/998 13/18722 0.509519689891988 0.766849899373326 ERRFI1 1 GO:0061744 motor behavior 1/998 13/18722 0.509519689891988 0.766849899373326 DPP4 1 GO:0070254 mucus secretion 1/998 13/18722 0.509519689891988 0.766849899373326 EGFR 1 GO:0070316 regulation of G0 to G1 transition 1/998 13/18722 0.509519689891988 0.766849899373326 FOXO4 1 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 1/998 13/18722 0.509519689891988 0.766849899373326 HSPA1B 1 GO:0070486 leukocyte aggregation 1/998 13/18722 0.509519689891988 0.766849899373326 BMP7 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/998 13/18722 0.509519689891988 0.766849899373326 ORMDL1 1 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/998 13/18722 0.509519689891988 0.766849899373326 ATP2B4 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/998 13/18722 0.509519689891988 0.766849899373326 IARS2 1 GO:0110096 cellular response to aldehyde 1/998 13/18722 0.509519689891988 0.766849899373326 ADH5 1 GO:0120305 regulation of pigmentation 1/998 13/18722 0.509519689891988 0.766849899373326 BCL2 1 GO:1900044 regulation of protein K63-linked ubiquitination 1/998 13/18722 0.509519689891988 0.766849899373326 UBR5 1 GO:1900121 negative regulation of receptor binding 1/998 13/18722 0.509519689891988 0.766849899373326 ATP2A2 1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/998 13/18722 0.509519689891988 0.766849899373326 PMAIP1 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/998 13/18722 0.509519689891988 0.766849899373326 ANK3 1 GO:1902947 regulation of tau-protein kinase activity 1/998 13/18722 0.509519689891988 0.766849899373326 HSP90AA1 1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1/998 13/18722 0.509519689891988 0.766849899373326 NSD1 1 GO:1903054 negative regulation of extracellular matrix organization 1/998 13/18722 0.509519689891988 0.766849899373326 DPP4 1 GO:1904478 regulation of intestinal absorption 1/998 13/18722 0.509519689891988 0.766849899373326 LPCAT3 1 GO:1904590 negative regulation of protein import 1/998 13/18722 0.509519689891988 0.766849899373326 FERMT1 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/998 13/18722 0.509519689891988 0.766849899373326 HUWE1 1 GO:1905038 regulation of membrane lipid metabolic process 1/998 13/18722 0.509519689891988 0.766849899373326 ORMDL1 1 GO:1905244 regulation of modification of synaptic structure 1/998 13/18722 0.509519689891988 0.766849899373326 CLN3 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/998 13/18722 0.509519689891988 0.766849899373326 GATA3 1 GO:2001023 regulation of response to drug 1/998 13/18722 0.509519689891988 0.766849899373326 ADIRF 1 GO:0097529 myeloid leukocyte migration 12/998 220/18722 0.509701968997744 0.766903164304675 CSF3R/DPP4/ANO6/CD47/VAV3/BSG/P2RX4/SWAP70/JAM3/MMP14/PTK2/PPIB 12 GO:0002700 regulation of production of molecular mediator of immune response 9/998 164/18722 0.513103966325185 0.771124901477819 TFRC/CD55/PRKDC/TLR3/RIF1/DHX36/FZD5/DDX1/GATA3 9 GO:0003180 aortic valve morphogenesis 2/998 32/18722 0.51472328704275 0.771124901477819 EFNA1/GATA3 2 GO:0008156 negative regulation of DNA replication 2/998 32/18722 0.51472328704275 0.771124901477819 WAPL/PDS5A 2 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 2/998 32/18722 0.51472328704275 0.771124901477819 PPP1R10/NFE2L2 2 GO:0030431 sleep 2/998 32/18722 0.51472328704275 0.771124901477819 ADRB1/SLC29A1 2 GO:0035456 response to interferon-beta 2/998 32/18722 0.51472328704275 0.771124901477819 TLR3/UBE2G2 2 GO:0035883 enteroendocrine cell differentiation 2/998 32/18722 0.51472328704275 0.771124901477819 CDK6/GSK3B 2 GO:0042044 fluid transport 2/998 32/18722 0.51472328704275 0.771124901477819 AHCYL1/EXT2 2 GO:0045761 regulation of adenylate cyclase activity 2/998 32/18722 0.51472328704275 0.771124901477819 AKAP9/NF1 2 GO:0050685 positive regulation of mRNA processing 2/998 32/18722 0.51472328704275 0.771124901477819 TRA2B/DHX36 2 GO:0071875 adrenergic receptor signaling pathway 2/998 32/18722 0.51472328704275 0.771124901477819 ADRB1/ATP2B4 2 GO:0090022 regulation of neutrophil chemotaxis 2/998 32/18722 0.51472328704275 0.771124901477819 DPP4/JAM3 2 GO:1900745 positive regulation of p38MAPK cascade 2/998 32/18722 0.51472328704275 0.771124901477819 MAP3K4/EMC10 2 GO:1901185 negative regulation of ERBB signaling pathway 2/998 32/18722 0.51472328704275 0.771124901477819 EGFR/ERRFI1 2 GO:2000191 regulation of fatty acid transport 2/998 32/18722 0.51472328704275 0.771124901477819 PLA2R1/P2RX4 2 GO:0010874 regulation of cholesterol efflux 3/998 51/18722 0.515954689371479 0.772304883373994 LRP1/ABCA1/PPARG 3 GO:0045661 regulation of myoblast differentiation 3/998 51/18722 0.515954689371479 0.772304883373994 MBNL3/MAPK14/FLOT2 3 GO:0071622 regulation of granulocyte chemotaxis 3/998 51/18722 0.515954689371479 0.772304883373994 DPP4/JAM3/PTK2 3 GO:0051480 regulation of cytosolic calcium ion concentration 19/998 353/18722 0.516524835241021 0.772936705300479 ATP2B1/ITGAV/GJA1/CD55/TGM2/LRP1/CD24/GTF2I/ATP2B4/MCOLN3/DMD/CLN3/TRPV6/P2RX4/SWAP70/BCAP31/GPR157/BCL2/SPPL3 19 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 4/998 70/18722 0.516820251287158 0.773157172484314 TFRC/HSPD1/SWAP70/RIF1 4 GO:0016054 organic acid catabolic process 13/998 240/18722 0.517000469277661 0.773205227756709 GLDC/SLC27A2/ATP2B4/HADHA/QPRT/CROT/ECHDC2/ACADVL/ECI2/CDO1/CPT2/ECHDC1/ETFA 13 GO:0022037 metencephalon development 6/998 108/18722 0.518364047689763 0.774578904690399 HSPA5/RERE/NCSTN/BCL2/SDF4/OPHN1 6 GO:0098659 inorganic cation import across plasma membrane 6/998 108/18722 0.518364047689763 0.774578904690399 DLG1/SLC39A10/ATP2B4/SLC12A9/SLC9A1/TRPV6 6 GO:0099587 inorganic ion import across plasma membrane 6/998 108/18722 0.518364047689763 0.774578904690399 DLG1/SLC39A10/ATP2B4/SLC12A9/SLC9A1/TRPV6 6 GO:0031349 positive regulation of defense response 15/998 278/18722 0.518654100504417 0.774790574744939 EGFR/APP/GJA1/CADM1/TGM2/CD47/PRKDC/IL6ST/HSPD1/TLR3/SFPQ/HSP90AA1/PDCD4/SNX4/HEXIM1 15 GO:0010675 regulation of cellular carbohydrate metabolic process 8/998 146/18722 0.519813010613831 0.776299693482497 DDB1/SLC35B4/SORBS1/FAM3C/RANBP2/GSK3B/PMAIP1/PHLDA2 8 GO:0042110 T cell activation 26/998 487/18722 0.525998558435315 0.77799494860526 CD46/CTSL/DPP4/TFRC/DLG5/DLG1/CD55/CD24/CD47/PRKDC/DDOST/IL6ST/HSPD1/GLI3/DOCK8/PAWR/NCSTN/YES1/EIF2AK4/CTNNB1/FZD5/GATA3/BCL2/FLOT2/PNP/KDELR1 26 GO:0034766 negative regulation of ion transmembrane transport 6/998 109/18722 0.527456932829339 0.77799494860526 SLC43A2/ANK3/ARL6IP5/FMR1/NEDD4/GOPC 6 GO:0035303 regulation of dephosphorylation 7/998 128/18722 0.527488034813899 0.77799494860526 HSP90B1/SLC39A10/SWAP70/BOD1L1/SPPL3/GSK3B/PPP6R2 7 GO:0008344 adult locomotory behavior 4/998 71/18722 0.52810035569026 0.77799494860526 APP/PUM1/EPS8/OXR1 4 GO:0050818 regulation of coagulation 4/998 71/18722 0.52810035569026 0.77799494860526 ANO6/ANXA5/NFE2L2/ANXA2 4 GO:0061515 myeloid cell development 4/998 71/18722 0.52810035569026 0.77799494860526 FBN1/APP/WASF2/ANXA2 4 GO:0010662 regulation of striated muscle cell apoptotic process 3/998 52/18722 0.529160024797808 0.77799494860526 BMP7/PPP1R10/NFE2L2 3 GO:0043277 apoptotic cell clearance 3/998 52/18722 0.529160024797808 0.77799494860526 ITGAV/TGM2/LRP1 3 GO:0048260 positive regulation of receptor-mediated endocytosis 3/998 52/18722 0.529160024797808 0.77799494860526 AHI1/FMR1/ANXA2 3 GO:1903426 regulation of reactive oxygen species biosynthetic process 3/998 52/18722 0.529160024797808 0.77799494860526 SLC5A3/HSPD1/PAGE4 3 GO:0002790 peptide secretion 13/998 242/18722 0.529239975446116 0.77799494860526 EGFR/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ABCA1/ISL1/SYT7/SLC16A1/TCF7L2 13 GO:0021700 developmental maturation 15/998 280/18722 0.530037717832345 0.77799494860526 APP/DAG1/RERE/TFCP2L1/FERMT1/PLXNB1/NRCAM/ANKRD17/CLSTN1/PPARG/CTNNB1/FZD5/GATA3/BCL2/MAP3K13 15 GO:0001881 receptor recycling 2/998 33/18722 0.531381189064933 0.77799494860526 NSG1/ANXA2 2 GO:0001975 response to amphetamine 2/998 33/18722 0.531381189064933 0.77799494860526 RANBP2/HDAC2 2 GO:0006482 protein demethylation 2/998 33/18722 0.531381189064933 0.77799494860526 KDM5B/KDM4B 2 GO:0008214 protein dealkylation 2/998 33/18722 0.531381189064933 0.77799494860526 KDM5B/KDM4B 2 GO:0010737 protein kinase A signaling 2/998 33/18722 0.531381189064933 0.77799494860526 EZR/RDX 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/998 33/18722 0.531381189064933 0.77799494860526 CLN3/KRAS 2 GO:0035025 positive regulation of Rho protein signal transduction 2/998 33/18722 0.531381189064933 0.77799494860526 ADGRG1/NET1 2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 2/998 33/18722 0.531381189064933 0.77799494860526 VAV3/PTK2 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/998 33/18722 0.531381189064933 0.77799494860526 ZNF451/DHX36 2 GO:0099084 postsynaptic specialization organization 2/998 33/18722 0.531381189064933 0.77799494860526 DLG1/OPHN1 2 GO:0110110 positive regulation of animal organ morphogenesis 2/998 33/18722 0.531381189064933 0.77799494860526 CTNNB1/GATA3 2 GO:0150117 positive regulation of cell-substrate junction organization 2/998 33/18722 0.531381189064933 0.77799494860526 NRP1/FERMT2 2 GO:1901976 regulation of cell cycle checkpoint 2/998 33/18722 0.531381189064933 0.77799494860526 TPR/PPP1R10 2 GO:1902992 negative regulation of amyloid precursor protein catabolic process 2/998 33/18722 0.531381189064933 0.77799494860526 RTN4/FLOT2 2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/998 33/18722 0.531381189064933 0.77799494860526 EGFR/CCND1 2 GO:0044270 cellular nitrogen compound catabolic process 24/998 451/18722 0.533810654405151 0.77799494860526 KCNQ1OT1/NUDT4/LIN28B/FUS/SND1/QPRT/TTC37/TET2/PUM1/LRPPRC/DCP2/SMPDL3A/FMR1/DICER1/VCP/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/PNP/HNRNPU 24 GO:0007254 JNK cascade 9/998 167/18722 0.535206710384543 0.77799494860526 EGFR/APP/HACD3/IGF1R/TLR3/MARVELD3/DUSP9/PDCD4/MAP3K13 9 GO:1903900 regulation of viral life cycle 8/998 148/18722 0.535424480545932 0.77799494860526 DDB1/HACD3/P4HB/MPHOSPH8/FMR1/TOP2B/PKN2/BCL2 8 GO:2001056 positive regulation of cysteine-type endopeptidase activity 8/998 148/18722 0.535424480545932 0.77799494860526 ASPH/PERP/ARL6IP5/HSPD1/PPARG/BCAP31/VCP/PMAIP1 8 GO:0000054 ribosomal subunit export from nucleus 1/998 14/18722 0.535683533469293 0.77799494860526 LSG1 1 GO:0001711 endodermal cell fate commitment 1/998 14/18722 0.535683533469293 0.77799494860526 CTNNB1 1 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1/998 14/18722 0.535683533469293 0.77799494860526 TLR3 1 GO:0006047 UDP-N-acetylglucosamine metabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 GFPT1 1 GO:0006465 signal peptide processing 1/998 14/18722 0.535683533469293 0.77799494860526 SPPL3 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/998 14/18722 0.535683533469293 0.77799494860526 PRLR 1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 1/998 14/18722 0.535683533469293 0.77799494860526 ERRFI1 1 GO:0007638 mechanosensory behavior 1/998 14/18722 0.535683533469293 0.77799494860526 SLC1A3 1 GO:0009158 ribonucleoside monophosphate catabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 PNP 1 GO:0009159 deoxyribonucleoside monophosphate catabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 PNP 1 GO:0010457 centriole-centriole cohesion 1/998 14/18722 0.535683533469293 0.77799494860526 CTNNB1 1 GO:0010838 positive regulation of keratinocyte proliferation 1/998 14/18722 0.535683533469293 0.77799494860526 TP63 1 GO:0010839 negative regulation of keratinocyte proliferation 1/998 14/18722 0.535683533469293 0.77799494860526 FGFR2 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/998 14/18722 0.535683533469293 0.77799494860526 MYLIP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/998 14/18722 0.535683533469293 0.77799494860526 DAG1 1 GO:0018158 protein oxidation 1/998 14/18722 0.535683533469293 0.77799494860526 SUMF1 1 GO:0022038 corpus callosum development 1/998 14/18722 0.535683533469293 0.77799494860526 RYK 1 GO:0030213 hyaluronan biosynthetic process 1/998 14/18722 0.535683533469293 0.77799494860526 CLTC 1 GO:0031468 nuclear membrane reassembly 1/998 14/18722 0.535683533469293 0.77799494860526 REEP3 1 GO:0032688 negative regulation of interferon-beta production 1/998 14/18722 0.535683533469293 0.77799494860526 YY1 1 GO:0032966 negative regulation of collagen biosynthetic process 1/998 14/18722 0.535683533469293 0.77799494860526 ERRFI1 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/998 14/18722 0.535683533469293 0.77799494860526 SNX4 1 GO:0033169 histone H3-K9 demethylation 1/998 14/18722 0.535683533469293 0.77799494860526 KDM4B 1 GO:0033750 ribosome localization 1/998 14/18722 0.535683533469293 0.77799494860526 LSG1 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/998 14/18722 0.535683533469293 0.77799494860526 RDX 1 GO:0035641 locomotory exploration behavior 1/998 14/18722 0.535683533469293 0.77799494860526 DPP4 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/998 14/18722 0.535683533469293 0.77799494860526 LPCAT3 1 GO:0036444 calcium import into the mitochondrion 1/998 14/18722 0.535683533469293 0.77799494860526 AFG3L2 1 GO:0038166 angiotensin-activated signaling pathway 1/998 14/18722 0.535683533469293 0.77799494860526 AHCYL1 1 GO:0042415 norepinephrine metabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 GATA3 1 GO:0043306 positive regulation of mast cell degranulation 1/998 14/18722 0.535683533469293 0.77799494860526 SNX4 1 GO:0043374 CD8-positive, alpha-beta T cell differentiation 1/998 14/18722 0.535683533469293 0.77799494860526 BCL2 1 GO:0043455 regulation of secondary metabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 OPN3 1 GO:0044154 histone H3-K14 acetylation 1/998 14/18722 0.535683533469293 0.77799494860526 GATA3 1 GO:0044764 multi-organism cellular process 1/998 14/18722 0.535683533469293 0.77799494860526 CTSL 1 GO:0045023 G0 to G1 transition 1/998 14/18722 0.535683533469293 0.77799494860526 FOXO4 1 GO:0045472 response to ether 1/998 14/18722 0.535683533469293 0.77799494860526 MDM2 1 GO:0045579 positive regulation of B cell differentiation 1/998 14/18722 0.535683533469293 0.77799494860526 MMP14 1 GO:0046341 CDP-diacylglycerol metabolic process 1/998 14/18722 0.535683533469293 0.77799494860526 CDS1 1 GO:0048021 regulation of melanin biosynthetic process 1/998 14/18722 0.535683533469293 0.77799494860526 OPN3 1 GO:0048148 behavioral response to cocaine 1/998 14/18722 0.535683533469293 0.77799494860526 HOMER1 1 GO:0048172 regulation of short-term neuronal synaptic plasticity 1/998 14/18722 0.535683533469293 0.77799494860526 CLN3 1 GO:0048291 isotype switching to IgG isotypes 1/998 14/18722 0.535683533469293 0.77799494860526 HSPD1 1 GO:0048368 lateral mesoderm development 1/998 14/18722 0.535683533469293 0.77799494860526 YAP1 1 GO:0048875 chemical homeostasis within a tissue 1/998 14/18722 0.535683533469293 0.77799494860526 HOMER1 1 GO:0050872 white fat cell differentiation 1/998 14/18722 0.535683533469293 0.77799494860526 PPARG 1 GO:0051764 actin crosslink formation 1/998 14/18722 0.535683533469293 0.77799494860526 EPS8 1 GO:0051984 positive regulation of chromosome segregation 1/998 14/18722 0.535683533469293 0.77799494860526 HNRNPU 1 GO:0055057 neuroblast division 1/998 14/18722 0.535683533469293 0.77799494860526 FGFR2 1 GO:0060911 cardiac cell fate commitment 1/998 14/18722 0.535683533469293 0.77799494860526 ISL1 1 GO:0061709 reticulophagy 1/998 14/18722 0.535683533469293 0.77799494860526 UFL1 1 GO:0070986 left/right axis specification 1/998 14/18722 0.535683533469293 0.77799494860526 AHI1 1 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 1/998 14/18722 0.535683533469293 0.77799494860526 ATP2B4 1 GO:0090128 regulation of synapse maturation 1/998 14/18722 0.535683533469293 0.77799494860526 CLSTN1 1 GO:0090715 immunological memory formation process 1/998 14/18722 0.535683533469293 0.77799494860526 CD46 1 GO:0097091 synaptic vesicle clustering 1/998 14/18722 0.535683533469293 0.77799494860526 CTNNB1 1 GO:0097531 mast cell migration 1/998 14/18722 0.535683533469293 0.77799494860526 SWAP70 1 GO:0098734 macromolecule depalmitoylation 1/998 14/18722 0.535683533469293 0.77799494860526 LYPLA1 1 GO:1900376 regulation of secondary metabolite biosynthetic process 1/998 14/18722 0.535683533469293 0.77799494860526 OPN3 1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/998 14/18722 0.535683533469293 0.77799494860526 BCL2 1 GO:1902916 positive regulation of protein polyubiquitination 1/998 14/18722 0.535683533469293 0.77799494860526 SKP2 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/998 14/18722 0.535683533469293 0.77799494860526 HUWE1 1 GO:1905049 negative regulation of metallopeptidase activity 1/998 14/18722 0.535683533469293 0.77799494860526 LRP1 1 GO:1905208 negative regulation of cardiocyte differentiation 1/998 14/18722 0.535683533469293 0.77799494860526 EGFR 1 GO:2001140 positive regulation of phospholipid transport 1/998 14/18722 0.535683533469293 0.77799494860526 TMEM30A 1 GO:2001171 positive regulation of ATP biosynthetic process 1/998 14/18722 0.535683533469293 0.77799494860526 VCP 1 GO:2001256 regulation of store-operated calcium entry 1/998 14/18722 0.535683533469293 0.77799494860526 HOMER1 1 GO:0098813 nuclear chromosome segregation 15/998 281/18722 0.535700409928349 0.77799494860526 EML4/DYNC1H1/ATRX/TPR/SFPQ/TOP2B/RAD21/CTNNB1/SUN1/WAPL/ANAPC5/PDS5A/NIPBL/STAG1/HNRNPU 15 GO:0007088 regulation of mitotic nuclear division 6/998 110/18722 0.53647906193774 0.778909116345089 BMP7/LRP5/OBSL1/TPR/RAD21/ANAPC5 6 GO:0060191 regulation of lipase activity 5/998 91/18722 0.537536322299967 0.780227172290278 EGFR/LRP1/PLA2R1/FGFR2/ARL1 5 GO:0032729 positive regulation of interferon-gamma production 4/998 72/18722 0.539250419434385 0.782280200018595 HSPD1/ISL1/TLR3/FZD5 4 GO:0033045 regulation of sister chromatid segregation 4/998 72/18722 0.539250419434385 0.782280200018595 TPR/RAD21/ANAPC5/HNRNPU 4 GO:0008037 cell recognition 12/998 225/18722 0.541502515210066 0.785329064419931 APP/COLEC12/NRP1/DLG1/CADM1/SPESP1/FOLR1/B4GALT1/NRCAM/DOCK8/BSG/RTN4 12 GO:0045806 negative regulation of endocytosis 3/998 53/18722 0.542161657138824 0.78584842085558 ITGAV/LRPAP1/ATXN2 3 GO:0099172 presynapse organization 3/998 53/18722 0.542161657138824 0.78584842085558 APP/EIF4G1/VPS35 3 GO:0006282 regulation of DNA repair 7/998 130/18722 0.544095378762279 0.787994999311472 EGFR/PARP1/FUS/PRKDC/SETD2/RIF1/UBR5 7 GO:0006352 DNA-templated transcription, initiation 7/998 130/18722 0.544095378762279 0.787994999311472 ZNF451/BCLAF1/SMARCA5/DHX36/TFAM/BDP1/CDK7 7 GO:0043467 regulation of generation of precursor metabolites and energy 7/998 130/18722 0.544095378762279 0.787994999311472 APP/IL10RB/OPN3/SORBS1/VCP/GSK3B/PHLDA2 7 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 6/998 111/18722 0.545427047690866 0.788758603258306 EGFR/IGF1R/ERBB3/PLXNB1/NEDD4/PTK2 6 GO:0015833 peptide transport 14/998 264/18722 0.547150712106858 0.788758603258306 EGFR/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/SLC13A3/CAMK2G/ABCA1/ISL1/SYT7/SLC16A1/TCF7L2 14 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 14/998 264/18722 0.547150712106858 0.788758603258306 EGFR/APP/NRP1/CD24/IL6ST/ERBB3/ISL1/EFNA1/YES1/SUZ12/PTPN1/ERRFI1/NEDD9/HDAC2 14 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 2/998 34/18722 0.547644152231419 0.788758603258306 CTSL/CTSV 2 GO:0010661 positive regulation of muscle cell apoptotic process 2/998 34/18722 0.547644152231419 0.788758603258306 PPARG/PDCD4 2 GO:0031128 developmental induction 2/998 34/18722 0.547644152231419 0.788758603258306 CTNNB1/FZD5 2 GO:0032743 positive regulation of interleukin-2 production 2/998 34/18722 0.547644152231419 0.788758603258306 SPTBN1/PNP 2 GO:0032770 positive regulation of monooxygenase activity 2/998 34/18722 0.547644152231419 0.788758603258306 PIK3CB/KRAS 2 GO:0035590 purinergic nucleotide receptor signaling pathway 2/998 34/18722 0.547644152231419 0.788758603258306 ANO6/P2RX4 2 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2/998 34/18722 0.547644152231419 0.788758603258306 PUM1/ANKRD17 2 GO:0050931 pigment cell differentiation 2/998 34/18722 0.547644152231419 0.788758603258306 GLI3/BCL2 2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 2/998 34/18722 0.547644152231419 0.788758603258306 TGM2/GPR157 2 GO:0070232 regulation of T cell apoptotic process 2/998 34/18722 0.547644152231419 0.788758603258306 EFNA1/DOCK8 2 GO:0090075 relaxation of muscle 2/998 34/18722 0.547644152231419 0.788758603258306 P2RX4/ATP2A2 2 GO:2000352 negative regulation of endothelial cell apoptotic process 2/998 34/18722 0.547644152231419 0.788758603258306 GATA3/NFE2L2 2 GO:2000780 negative regulation of double-strand break repair 2/998 34/18722 0.547644152231419 0.788758603258306 RIF1/UBR5 2 GO:0002703 regulation of leukocyte mediated immunity 12/998 226/18722 0.547780197067996 0.788758603258306 CD46/TFRC/CADM1/CD55/HSPD1/TLR3/RIF1/DHX36/FZD5/DDX1/GATA3/SNX4 12 GO:0032732 positive regulation of interleukin-1 production 4/998 73/18722 0.550265159173727 0.788758603258306 APP/ISL1/FZD5/HDAC2 4 GO:0001959 regulation of cytokine-mediated signaling pathway 8/998 150/18722 0.550839885692803 0.788758603258306 CD24/SPPL2A/TRIM44/PTPN1/PPARG/SPPL2B/HSPA1B/OTUD4 8 GO:0000956 nuclear-transcribed mRNA catabolic process 6/998 112/18722 0.554297667049299 0.788758603258306 TTC37/DCP2/DHX36/AGO2/TNRC6A/SECISBP2 6 GO:0001676 long-chain fatty acid metabolic process 6/998 112/18722 0.554297667049299 0.788758603258306 SLC27A2/CPT2/ACSF2/CYP2J2/ACSL3/QKI 6 GO:0032609 interferon-gamma production 6/998 112/18722 0.554297667049299 0.788758603258306 CD47/HSPD1/ISL1/TLR3/FZD5/GATA3 6 GO:0032649 regulation of interferon-gamma production 6/998 112/18722 0.554297667049299 0.788758603258306 CD47/HSPD1/ISL1/TLR3/FZD5/GATA3 6 GO:0035601 protein deacylation 6/998 112/18722 0.554297667049299 0.788758603258306 TBL1X/RCOR1/SFPQ/NIPBL/LYPLA1/HDAC2 6 GO:0070228 regulation of lymphocyte apoptotic process 3/998 54/18722 0.554953036209866 0.788758603258306 SLC39A10/EFNA1/DOCK8 3 GO:2000300 regulation of synaptic vesicle exocytosis 3/998 54/18722 0.554953036209866 0.788758603258306 FMR1/ATP2A2/GSK3B 3 GO:0043535 regulation of blood vessel endothelial cell migration 8/998 151/18722 0.558468431964234 0.788758603258306 NRP1/NF1/ATP2B4/EFNA1/P2RX4/PPARG/PLK2/NFE2L2 8 GO:1901361 organic cyclic compound catabolic process 26/998 495/18722 0.560324418543235 0.788758603258306 STS/KCNQ1OT1/NUDT4/LIN28B/FUS/SND1/QPRT/TTC37/TET2/PUM1/LRPPRC/DCP2/SMPDL3A/FMR1/DICER1/VCP/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/NFE2L2/PNP/HNRNPU 26 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/998 15/18722 0.560453034944472 0.788758603258306 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/998 15/18722 0.560453034944472 0.788758603258306 RPS21 1 GO:0000722 telomere maintenance via recombination 1/998 15/18722 0.560453034944472 0.788758603258306 RAD50 1 GO:0002070 epithelial cell maturation 1/998 15/18722 0.560453034944472 0.788758603258306 TFCP2L1 1 GO:0002836 positive regulation of response to tumor cell 1/998 15/18722 0.560453034944472 0.788758603258306 HSPD1 1 GO:0002839 positive regulation of immune response to tumor cell 1/998 15/18722 0.560453034944472 0.788758603258306 HSPD1 1 GO:0006098 pentose-phosphate shunt 1/998 15/18722 0.560453034944472 0.788758603258306 RPIA 1 GO:0006268 DNA unwinding involved in DNA replication 1/998 15/18722 0.560453034944472 0.788758603258306 PURA 1 GO:0006878 cellular copper ion homeostasis 1/998 15/18722 0.560453034944472 0.788758603258306 APP 1 GO:0007000 nucleolus organization 1/998 15/18722 0.560453034944472 0.788758603258306 SMARCA5 1 GO:0007216 G protein-coupled glutamate receptor signaling pathway 1/998 15/18722 0.560453034944472 0.788758603258306 HOMER1 1 GO:0009163 nucleoside biosynthetic process 1/998 15/18722 0.560453034944472 0.788758603258306 PNP 1 GO:0010713 negative regulation of collagen metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 ERRFI1 1 GO:0010832 negative regulation of myotube differentiation 1/998 15/18722 0.560453034944472 0.788758603258306 BHLHE41 1 GO:0010889 regulation of sequestering of triglyceride 1/998 15/18722 0.560453034944472 0.788758603258306 PPARG 1 GO:0014841 skeletal muscle satellite cell proliferation 1/998 15/18722 0.560453034944472 0.788758603258306 PAXBP1 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/998 15/18722 0.560453034944472 0.788758603258306 PAXBP1 1 GO:0016114 terpenoid biosynthetic process 1/998 15/18722 0.560453034944472 0.788758603258306 ALDH1A3 1 GO:0018298 protein-chromophore linkage 1/998 15/18722 0.560453034944472 0.788758603258306 OPN3 1 GO:0021542 dentate gyrus development 1/998 15/18722 0.560453034944472 0.788758603258306 CDK6 1 GO:0023035 CD40 signaling pathway 1/998 15/18722 0.560453034944472 0.788758603258306 ITGB1 1 GO:0032310 prostaglandin secretion 1/998 15/18722 0.560453034944472 0.788758603258306 P2RX4 1 GO:0032328 alanine transport 1/998 15/18722 0.560453034944472 0.788758603258306 SLC38A2 1 GO:0032354 response to follicle-stimulating hormone 1/998 15/18722 0.560453034944472 0.788758603258306 TGFBR3 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/998 15/18722 0.560453034944472 0.788758603258306 ISL1 1 GO:0032897 negative regulation of viral transcription 1/998 15/18722 0.560453034944472 0.788758603258306 HEXIM1 1 GO:0032933 SREBP signaling pathway 1/998 15/18722 0.560453034944472 0.788758603258306 LPCAT3 1 GO:0034380 high-density lipoprotein particle assembly 1/998 15/18722 0.560453034944472 0.788758603258306 ABCA1 1 GO:0034404 nucleobase-containing small molecule biosynthetic process 1/998 15/18722 0.560453034944472 0.788758603258306 PNP 1 GO:0035493 SNARE complex assembly 1/998 15/18722 0.560453034944472 0.788758603258306 UVRAG 1 GO:0036376 sodium ion export across plasma membrane 1/998 15/18722 0.560453034944472 0.788758603258306 SLC9A1 1 GO:0042159 lipoprotein catabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 LYPLA1 1 GO:0042249 establishment of planar polarity of embryonic epithelium 1/998 15/18722 0.560453034944472 0.788758603258306 DVL3 1 GO:0042754 negative regulation of circadian rhythm 1/998 15/18722 0.560453034944472 0.788758603258306 SFPQ 1 GO:0042976 activation of Janus kinase activity 1/998 15/18722 0.560453034944472 0.788758603258306 PRLR 1 GO:0043508 negative regulation of JUN kinase activity 1/998 15/18722 0.560453034944472 0.788758603258306 PDCD4 1 GO:0043981 histone H4-K5 acetylation 1/998 15/18722 0.560453034944472 0.788758603258306 PHF20 1 GO:0043982 histone H4-K8 acetylation 1/998 15/18722 0.560453034944472 0.788758603258306 PHF20 1 GO:0044793 negative regulation by host of viral process 1/998 15/18722 0.560453034944472 0.788758603258306 EIF2AK4 1 GO:0045064 T-helper 2 cell differentiation 1/998 15/18722 0.560453034944472 0.788758603258306 GATA3 1 GO:0045346 regulation of MHC class II biosynthetic process 1/998 15/18722 0.560453034944472 0.788758603258306 HDAC2 1 GO:0045475 locomotor rhythm 1/998 15/18722 0.560453034944472 0.788758603258306 ZFHX3 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/998 15/18722 0.560453034944472 0.788758603258306 SORBS1 1 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 1/998 15/18722 0.560453034944472 0.788758603258306 ANAPC5 1 GO:0046459 short-chain fatty acid metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 ACSS1 1 GO:0046500 S-adenosylmethionine metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 AHCYL1 1 GO:0048308 organelle inheritance 1/998 15/18722 0.560453034944472 0.788758603258306 GOLGA2 1 GO:0048313 Golgi inheritance 1/998 15/18722 0.560453034944472 0.788758603258306 GOLGA2 1 GO:0050746 regulation of lipoprotein metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 ITGAV 1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 1/998 15/18722 0.560453034944472 0.788758603258306 HNRNPU 1 GO:0051608 histamine transport 1/998 15/18722 0.560453034944472 0.788758603258306 SNX4 1 GO:0051775 response to redox state 1/998 15/18722 0.560453034944472 0.788758603258306 ADH5 1 GO:0051791 medium-chain fatty acid metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 CROT 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/998 15/18722 0.560453034944472 0.788758603258306 LMNA 1 GO:0055091 phospholipid homeostasis 1/998 15/18722 0.560453034944472 0.788758603258306 ABCA1 1 GO:0060046 regulation of acrosome reaction 1/998 15/18722 0.560453034944472 0.788758603258306 B4GALT1 1 GO:0060253 negative regulation of glial cell proliferation 1/998 15/18722 0.560453034944472 0.788758603258306 DICER1 1 GO:0060413 atrial septum morphogenesis 1/998 15/18722 0.560453034944472 0.788758603258306 ISL1 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/998 15/18722 0.560453034944472 0.788758603258306 PGAP1 1 GO:0070207 protein homotrimerization 1/998 15/18722 0.560453034944472 0.788758603258306 SLC1A5 1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 1/998 15/18722 0.560453034944472 0.788758603258306 LSG1 1 GO:0072044 collecting duct development 1/998 15/18722 0.560453034944472 0.788758603258306 DLG5 1 GO:0072075 metanephric mesenchyme development 1/998 15/18722 0.560453034944472 0.788758603258306 BMP7 1 GO:0072224 metanephric glomerulus development 1/998 15/18722 0.560453034944472 0.788758603258306 LGR4 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/998 15/18722 0.560453034944472 0.788758603258306 CDH1 1 GO:0110156 methylguanosine-cap decapping 1/998 15/18722 0.560453034944472 0.788758603258306 DCP2 1 GO:1901741 positive regulation of myoblast fusion 1/998 15/18722 0.560453034944472 0.788758603258306 MAPK14 1 GO:1901970 positive regulation of mitotic sister chromatid separation 1/998 15/18722 0.560453034944472 0.788758603258306 ANAPC5 1 GO:1903727 positive regulation of phospholipid metabolic process 1/998 15/18722 0.560453034944472 0.788758603258306 ACSL3 1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 1/998 15/18722 0.560453034944472 0.788758603258306 LIN28B 1 GO:1904380 endoplasmic reticulum mannose trimming 1/998 15/18722 0.560453034944472 0.788758603258306 EDEM3 1 GO:1904424 regulation of GTP binding 1/998 15/18722 0.560453034944472 0.788758603258306 MET 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/998 15/18722 0.560453034944472 0.788758603258306 GPC3 1 GO:2000402 negative regulation of lymphocyte migration 1/998 15/18722 0.560453034944472 0.788758603258306 MIA3 1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity 1/998 15/18722 0.560453034944472 0.788758603258306 NEDD4 1 GO:2001138 regulation of phospholipid transport 1/998 15/18722 0.560453034944472 0.788758603258306 TMEM30A 1 GO:0002437 inflammatory response to antigenic stimulus 4/998 74/18722 0.561139707634509 0.788758603258306 YES1/MAPK14/GATA3/PLK2 4 GO:0006801 superoxide metabolic process 4/998 74/18722 0.561139707634509 0.788758603258306 EGFR/BMP7/SOD3/NFE2L2 4 GO:0044344 cellular response to fibroblast growth factor stimulus 6/998 113/18722 0.563087860266678 0.788758603258306 KDM5B/FGFR2/CTNNB1/GATA3/EXT2/GPC1 6 GO:0000460 maturation of 5.8S rRNA 2/998 35/18722 0.563506912498273 0.788758603258306 PRKDC/RPS21 2 GO:0000731 DNA synthesis involved in DNA repair 2/998 35/18722 0.563506912498273 0.788758603258306 USP10/VCP 2 GO:0001569 branching involved in blood vessel morphogenesis 2/998 35/18722 0.563506912498273 0.788758603258306 NRP1/CTNNB1 2 GO:0006084 acetyl-CoA metabolic process 2/998 35/18722 0.563506912498273 0.788758603258306 ACSS1/FASN 2 GO:0006298 mismatch repair 2/998 35/18722 0.563506912498273 0.788758603258306 SETD2/XPC 2 GO:0006471 protein ADP-ribosylation 2/998 35/18722 0.563506912498273 0.788758603258306 PARP1/TNKS2 2 GO:0006739 NADP metabolic process 2/998 35/18722 0.563506912498273 0.788758603258306 IDH1/RPIA 2 GO:0008608 attachment of spindle microtubules to kinetochore 2/998 35/18722 0.563506912498273 0.788758603258306 EML4/HNRNPU 2 GO:0018149 peptide cross-linking 2/998 35/18722 0.563506912498273 0.788758603258306 DSP/TGM2 2 GO:0021955 central nervous system neuron axonogenesis 2/998 35/18722 0.563506912498273 0.788758603258306 MYCBP2/HSP90AA1 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/998 35/18722 0.563506912498273 0.788758603258306 SMARCC1/USP14 2 GO:0043243 positive regulation of protein-containing complex disassembly 2/998 35/18722 0.563506912498273 0.788758603258306 IGF1R/UVRAG 2 GO:0045454 cell redox homeostasis 2/998 35/18722 0.563506912498273 0.788758603258306 PRDX4/NFE2L2 2 GO:0046627 negative regulation of insulin receptor signaling pathway 2/998 35/18722 0.563506912498273 0.788758603258306 KANK1/PTPN1 2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2/998 35/18722 0.563506912498273 0.788758603258306 NRP1/PLK2 2 GO:0098801 regulation of renal system process 2/998 35/18722 0.563506912498273 0.788758603258306 GJA1/GJA5 2 GO:1905207 regulation of cardiocyte differentiation 2/998 35/18722 0.563506912498273 0.788758603258306 EGFR/DHX36 2 GO:2000403 positive regulation of lymphocyte migration 2/998 35/18722 0.563506912498273 0.788758603258306 APP/DOCK8 2 GO:0048469 cell maturation 9/998 171/18722 0.56408706555569 0.789359037594816 APP/TFCP2L1/NRCAM/PPARG/CTNNB1/FZD5/GATA3/BCL2/MAP3K13 9 GO:0002042 cell migration involved in sprouting angiogenesis 5/998 94/18722 0.566692716105671 0.792687462026966 NRP1/ITGB1/EPHB4/MIA3/PLK2 5 GO:0000768 syncytium formation by plasma membrane fusion 3/998 55/18722 0.567528391698295 0.792687462026966 ERVW-1/MYOF/MAPK14 3 GO:0008333 endosome to lysosome transport 3/998 55/18722 0.567528391698295 0.792687462026966 HOOK2/VCP/AKTIP 3 GO:0010676 positive regulation of cellular carbohydrate metabolic process 3/998 55/18722 0.567528391698295 0.792687462026966 DDB1/SORBS1/PMAIP1 3 GO:0140253 cell-cell fusion 3/998 55/18722 0.567528391698295 0.792687462026966 ERVW-1/MYOF/MAPK14 3 GO:1902991 regulation of amyloid precursor protein catabolic process 3/998 55/18722 0.567528391698295 0.792687462026966 EFNA1/RTN4/FLOT2 3 GO:1905517 macrophage migration 3/998 55/18722 0.567528391698295 0.792687462026966 P2RX4/MMP14/PTK2 3 GO:0006650 glycerophospholipid metabolic process 16/998 306/18722 0.568395777384297 0.793669034500946 PGAP1/PISD/HADHA/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/SERINC2/PIK3CB/SH3YL1/PTDSS1/ACSL3/SERINC3/FAR1 16 GO:0046887 positive regulation of hormone secretion 7/998 133/18722 0.56853518273004 0.793669034500946 EGFR/GJA1/LRP1/ISL1/TCF7L2/SNX4/TMF1 7 GO:0002221 pattern recognition receptor signaling pathway 9/998 172/18722 0.571189192052318 0.796832451169955 COLEC12/LGR4/HSPD1/TLR3/PUM1/RTN4/ANKRD17/HSPA1B/OTUD4 9 GO:0046883 regulation of hormone secretion 13/998 249/18722 0.571263928459832 0.796832451169955 EGFR/DPP4/GJA1/LRP5/LRP1/ISL1/SYT7/KDM5B/SLC16A1/TCF7L2/RAB11FIP1/SNX4/TMF1 13 GO:0019751 polyol metabolic process 6/998 114/18722 0.57179472961897 0.796832451169955 SLC5A3/ISYNA1/NUDT4/PLPP3/SPTLC3/SGPP1 6 GO:1904892 regulation of receptor signaling pathway via STAT 6/998 114/18722 0.57179472961897 0.796832451169955 PRLR/IL10RB/LEPROT/SUZ12/PPARG/OCIAD1 6 GO:0006094 gluconeogenesis 4/998 75/18722 0.571869602477269 0.796832451169955 DDB1/SLC35B4/FAM3C/RANBP2 4 GO:0034121 regulation of toll-like receptor signaling pathway 4/998 75/18722 0.571869602477269 0.796832451169955 LGR4/TLR3/RTN4/OTUD4 4 GO:0045913 positive regulation of carbohydrate metabolic process 4/998 75/18722 0.571869602477269 0.796832451169955 APP/DDB1/SORBS1/PMAIP1 4 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5/998 95/18722 0.576200200610242 0.79700773793092 TRIM44/UFL1/CTNNB1/UBR5/HSPA1B 5 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2/998 36/18722 0.57896588714852 0.79700773793092 CTSL/CTSV 2 GO:0002691 regulation of cellular extravasation 2/998 36/18722 0.57896588714852 0.79700773793092 CD47/JAM3 2 GO:0006699 bile acid biosynthetic process 2/998 36/18722 0.57896588714852 0.79700773793092 SLC27A2/OSBPL9 2 GO:0010923 negative regulation of phosphatase activity 2/998 36/18722 0.57896588714852 0.79700773793092 BOD1L1/GSK3B 2 GO:0038179 neurotrophin signaling pathway 2/998 36/18722 0.57896588714852 0.79700773793092 KIDINS220/ZDHHC17 2 GO:0044743 protein transmembrane import into intracellular organelle 2/998 36/18722 0.57896588714852 0.79700773793092 HSPD1/TOMM20 2 GO:0045191 regulation of isotype switching 2/998 36/18722 0.57896588714852 0.79700773793092 TFRC/RIF1 2 GO:0045652 regulation of megakaryocyte differentiation 2/998 36/18722 0.57896588714852 0.79700773793092 SCIN/RCOR1 2 GO:0045738 negative regulation of DNA repair 2/998 36/18722 0.57896588714852 0.79700773793092 RIF1/UBR5 2 GO:0045746 negative regulation of Notch signaling pathway 2/998 36/18722 0.57896588714852 0.79700773793092 BMP7/MMP14 2 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2/998 36/18722 0.57896588714852 0.79700773793092 USP47/BCL2 2 GO:0002886 regulation of myeloid leukocyte mediated immunity 3/998 56/18722 0.579882695196785 0.79700773793092 DHX36/DDX1/SNX4 3 GO:0010518 positive regulation of phospholipase activity 3/998 56/18722 0.579882695196785 0.79700773793092 EGFR/FGFR2/ARL1 3 GO:0010658 striated muscle cell apoptotic process 3/998 56/18722 0.579882695196785 0.79700773793092 BMP7/PPP1R10/NFE2L2 3 GO:0032608 interferon-beta production 3/998 56/18722 0.579882695196785 0.79700773793092 TLR3/HSP90AA1/YY1 3 GO:0032648 regulation of interferon-beta production 3/998 56/18722 0.579882695196785 0.79700773793092 TLR3/HSP90AA1/YY1 3 GO:0048255 mRNA stabilization 3/998 56/18722 0.579882695196785 0.79700773793092 FUS/MAPK14/HNRNPU 3 GO:0051784 negative regulation of nuclear division 3/998 56/18722 0.579882695196785 0.79700773793092 BMP7/TPR/RAD21 3 GO:0070534 protein K63-linked ubiquitination 3/998 56/18722 0.579882695196785 0.79700773793092 HECTD1/NEDD4/UBR5 3 GO:0098781 ncRNA transcription 3/998 56/18722 0.579882695196785 0.79700773793092 ICE1/CDK7/ELL 3 GO:0021536 diencephalon development 4/998 76/18722 0.582450774697735 0.79700773793092 CDH1/NRP2/NRP1/ISL1 4 GO:0043536 positive regulation of blood vessel endothelial cell migration 4/998 76/18722 0.582450774697735 0.79700773793092 NRP1/P2RX4/PLK2/NFE2L2 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/998 76/18722 0.582450774697735 0.79700773793092 EGFR/SLC5A3/MAPK14/NFE2L2 4 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 10/998 193/18722 0.582647934815065 0.79700773793092 NRP1/CD24/IL6ST/ERBB3/ISL1/EFNA1/YES1/PTPN1/NEDD9/HDAC2 10 GO:0001732 formation of cytoplasmic translation initiation complex 1/998 16/18722 0.583902432021791 0.79700773793092 EIF3A 1 GO:0002830 positive regulation of type 2 immune response 1/998 16/18722 0.583902432021791 0.79700773793092 GATA3 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/998 16/18722 0.583902432021791 0.79700773793092 NR2F2 1 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 1/998 16/18722 0.583902432021791 0.79700773793092 TGFBR1 1 GO:0006349 regulation of gene expression by genetic imprinting 1/998 16/18722 0.583902432021791 0.79700773793092 DNMT3A 1 GO:0006544 glycine metabolic process 1/998 16/18722 0.583902432021791 0.79700773793092 GLDC 1 GO:0006740 NADPH regeneration 1/998 16/18722 0.583902432021791 0.79700773793092 RPIA 1 GO:0006750 glutathione biosynthetic process 1/998 16/18722 0.583902432021791 0.79700773793092 NFE2L2 1 GO:0006828 manganese ion transport 1/998 16/18722 0.583902432021791 0.79700773793092 TMEM165 1 GO:0014819 regulation of skeletal muscle contraction 1/998 16/18722 0.583902432021791 0.79700773793092 DMD 1 GO:0016584 nucleosome positioning 1/998 16/18722 0.583902432021791 0.79700773793092 SMARCA5 1 GO:0030575 nuclear body organization 1/998 16/18722 0.583902432021791 0.79700773793092 SF1 1 GO:0035067 negative regulation of histone acetylation 1/998 16/18722 0.583902432021791 0.79700773793092 ZNF451 1 GO:0035970 peptidyl-threonine dephosphorylation 1/998 16/18722 0.583902432021791 0.79700773793092 DUSP5 1 GO:0036342 post-anal tail morphogenesis 1/998 16/18722 0.583902432021791 0.79700773793092 TP63 1 GO:0042407 cristae formation 1/998 16/18722 0.583902432021791 0.79700773793092 AFG3L2 1 GO:0042481 regulation of odontogenesis 1/998 16/18722 0.583902432021791 0.79700773793092 SP6 1 GO:0042574 retinal metabolic process 1/998 16/18722 0.583902432021791 0.79700773793092 ALDH1A3 1 GO:0045342 MHC class II biosynthetic process 1/998 16/18722 0.583902432021791 0.79700773793092 HDAC2 1 GO:0045721 negative regulation of gluconeogenesis 1/998 16/18722 0.583902432021791 0.79700773793092 FAM3C 1 GO:0045722 positive regulation of gluconeogenesis 1/998 16/18722 0.583902432021791 0.79700773793092 DDB1 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/998 16/18722 0.583902432021791 0.79700773793092 MPHOSPH8 1 GO:0046037 GMP metabolic process 1/998 16/18722 0.583902432021791 0.79700773793092 DLG1 1 GO:0048385 regulation of retinoic acid receptor signaling pathway 1/998 16/18722 0.583902432021791 0.79700773793092 CALR 1 GO:0050862 positive regulation of T cell receptor signaling pathway 1/998 16/18722 0.583902432021791 0.79700773793092 KCNN4 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/998 16/18722 0.583902432021791 0.79700773793092 NR2F6 1 GO:0051014 actin filament severing 1/998 16/18722 0.583902432021791 0.79700773793092 SCIN 1 GO:0051238 sequestering of metal ion 1/998 16/18722 0.583902432021791 0.79700773793092 SLC30A7 1 GO:0051969 regulation of transmission of nerve impulse 1/998 16/18722 0.583902432021791 0.79700773793092 FMR1 1 GO:0060330 regulation of response to interferon-gamma 1/998 16/18722 0.583902432021791 0.79700773793092 PPARG 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/998 16/18722 0.583902432021791 0.79700773793092 PPARG 1 GO:0061684 chaperone-mediated autophagy 1/998 16/18722 0.583902432021791 0.79700773793092 HSP90AA1 1 GO:0070365 hepatocyte differentiation 1/998 16/18722 0.583902432021791 0.79700773793092 KRT18 1 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 1/998 16/18722 0.583902432021791 0.79700773793092 HSPA1B 1 GO:0071361 cellular response to ethanol 1/998 16/18722 0.583902432021791 0.79700773793092 DNMT3A 1 GO:0071501 cellular response to sterol depletion 1/998 16/18722 0.583902432021791 0.79700773793092 LPCAT3 1 GO:0071732 cellular response to nitric oxide 1/998 16/18722 0.583902432021791 0.79700773793092 MTR 1 GO:0072109 glomerular mesangium development 1/998 16/18722 0.583902432021791 0.79700773793092 BMP7 1 GO:0072283 metanephric renal vesicle morphogenesis 1/998 16/18722 0.583902432021791 0.79700773793092 CTNNB1 1 GO:0090231 regulation of spindle checkpoint 1/998 16/18722 0.583902432021791 0.79700773793092 TPR 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/998 16/18722 0.583902432021791 0.79700773793092 TPR 1 GO:0098884 postsynaptic neurotransmitter receptor internalization 1/998 16/18722 0.583902432021791 0.79700773793092 OPHN1 1 GO:0099010 modification of postsynaptic structure 1/998 16/18722 0.583902432021791 0.79700773793092 MYH10 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/998 16/18722 0.583902432021791 0.79700773793092 ATP2B1 1 GO:0140239 postsynaptic endocytosis 1/998 16/18722 0.583902432021791 0.79700773793092 OPHN1 1 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/998 16/18722 0.583902432021791 0.79700773793092 ANAPC5 1 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1/998 16/18722 0.583902432021791 0.79700773793092 BCL2 1 GO:1902306 negative regulation of sodium ion transmembrane transport 1/998 16/18722 0.583902432021791 0.79700773793092 NEDD4 1 GO:1903504 regulation of mitotic spindle checkpoint 1/998 16/18722 0.583902432021791 0.79700773793092 TPR 1 GO:1904862 inhibitory synapse assembly 1/998 16/18722 0.583902432021791 0.79700773793092 PLXNB1 1 GO:1905906 regulation of amyloid fibril formation 1/998 16/18722 0.583902432021791 0.79700773793092 APP 1 GO:2000001 regulation of DNA damage checkpoint 1/998 16/18722 0.583902432021791 0.79700773793092 PPP1R10 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/998 16/18722 0.583902432021791 0.79700773793092 CTNNA1 1 GO:0042157 lipoprotein metabolic process 7/998 135/18722 0.584485600051848 0.797595221607605 ITGAV/OLR1/LRP1/PGAP1/ABCA1/ZDHHC17/LYPLA1 7 GO:0042632 cholesterol homeostasis 5/998 96/18722 0.585596476526976 0.798902326612841 LRP5/CD24/LIMA1/ABCA1/MYLIP 5 GO:1903706 regulation of hemopoiesis 19/998 367/18722 0.586103246951718 0.799384809909854 FBN1/CD46/CSF3R/CDK6/PRKDC/SCIN/RCOR1/GLI3/TLR3/MAPK14/CTNNB1/MMP14/GATA3/RBFOX2/HSPA1B/MEIS2/PURB/PNP/HSPA9 19 GO:0045017 glycerolipid biosynthetic process 13/998 252/18722 0.588818212353645 0.802635336904794 PGAP1/PISD/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/PIK3CB/SH3YL1/PTDSS1/ACSL3/FAR1 13 GO:0006720 isoprenoid metabolic process 6/998 116/18722 0.588947706508766 0.802635336904794 EGFR/LRP2/LRP1/FDFT1/ADH5/ALDH1A3 6 GO:0098732 macromolecule deacylation 6/998 116/18722 0.588947706508766 0.802635336904794 TBL1X/RCOR1/SFPQ/NIPBL/LYPLA1/HDAC2 6 GO:0060326 cell chemotaxis 16/998 310/18722 0.589565466748886 0.803267563125244 MET/NRP1/CSF3R/DPP4/ANO6/CALR/GAB1/VAV3/BSG/TPBG/P2RX4/SWAP70/JAM3/PTK2/PLEC/PPIB 16 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 12/998 233/18722 0.590798542738742 0.80429804344455 ADGRG1/LGR5/ADRB1/LGR4/GNA12/ATP2B4/ABCA1/WASF2/S1PR2/GNAI1/ADGRG6/GNAS 12 GO:0016236 macroautophagy 15/998 291/18722 0.591029528028996 0.80429804344455 EXOC1/ATP6V1C2/HUWE1/ATP6V1B1/CLN3/UFL1/GABARAPL1/TMEM41B/NEDD4/UVRAG/VCP/LGALS8/ATP2A2/SNX14/VPS35 15 GO:0030219 megakaryocyte differentiation 3/998 57/18722 0.592011622657311 0.80429804344455 SCIN/RCOR1/WASF2 3 GO:0034205 amyloid-beta formation 3/998 57/18722 0.592011622657311 0.80429804344455 EFNA1/NCSTN/RTN4 3 GO:0051155 positive regulation of striated muscle cell differentiation 3/998 57/18722 0.592011622657311 0.80429804344455 MAPK14/MMP14/BCL2 3 GO:0045727 positive regulation of translation 7/998 136/18722 0.592351289409596 0.80429804344455 PRKDC/EIF4G1/FMR1/EIF2AK4/LARP4/DHX36/AGO2 7 GO:0072330 monocarboxylic acid biosynthetic process 11/998 214/18722 0.593108398218622 0.80429804344455 ACSS1/DEGS1/SLC27A2/HACD3/ACADVL/OSBPL9/ALDH1A3/ACSL3/FASN/QKI/TECR 11 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2/998 37/18722 0.59401901082593 0.80429804344455 DCP2/SECISBP2 2 GO:0001990 regulation of systemic arterial blood pressure by hormone 2/998 37/18722 0.59401901082593 0.80429804344455 MME/ENPEP 2 GO:0003016 respiratory system process 2/998 37/18722 0.59401901082593 0.80429804344455 GAA/ADH5 2 GO:0003176 aortic valve development 2/998 37/18722 0.59401901082593 0.80429804344455 EFNA1/GATA3 2 GO:0007340 acrosome reaction 2/998 37/18722 0.59401901082593 0.80429804344455 SPESP1/B4GALT1 2 GO:0016202 regulation of striated muscle tissue development 2/998 37/18722 0.59401901082593 0.80429804344455 CTNNB1/BCL2 2 GO:0032570 response to progesterone 2/998 37/18722 0.59401901082593 0.80429804344455 CLDN4/YAP1 2 GO:0033363 secretory granule organization 2/998 37/18722 0.59401901082593 0.80429804344455 ABCA1/TMF1 2 GO:0043029 T cell homeostasis 2/998 37/18722 0.59401901082593 0.80429804344455 BCL2/PMAIP1 2 GO:0043368 positive T cell selection 2/998 37/18722 0.59401901082593 0.80429804344455 CTSL/BCL2 2 GO:0043403 skeletal muscle tissue regeneration 2/998 37/18722 0.59401901082593 0.80429804344455 DAG1/KLF5 2 GO:0045730 respiratory burst 2/998 37/18722 0.59401901082593 0.80429804344455 CD55/CD24 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/998 37/18722 0.59401901082593 0.80429804344455 CRIM1/IGF1R 2 GO:0060306 regulation of membrane repolarization 2/998 37/18722 0.59401901082593 0.80429804344455 AKAP9/GJA5 2 GO:0090218 positive regulation of lipid kinase activity 2/998 37/18722 0.59401901082593 0.80429804344455 VAV3/PTK2 2 GO:1900016 negative regulation of cytokine production involved in inflammatory response 2/998 37/18722 0.59401901082593 0.80429804344455 PDCD4/CHID1 2 GO:1900077 negative regulation of cellular response to insulin stimulus 2/998 37/18722 0.59401901082593 0.80429804344455 KANK1/PTPN1 2 GO:0010596 negative regulation of endothelial cell migration 5/998 97/18722 0.594878566540828 0.804835707672886 SERPINF1/NR2F2/ATP2B4/PPARG/PTPRM 5 GO:0055092 sterol homeostasis 5/998 97/18722 0.594878566540828 0.804835707672886 LRP5/CD24/LIMA1/ABCA1/MYLIP 5 GO:1901216 positive regulation of neuron death 5/998 97/18722 0.594878566540828 0.804835707672886 NF1/PARP1/TFAP2A/CTNNB1/GSK3B 5 GO:0071674 mononuclear cell migration 10/998 196/18722 0.602347054106226 0.806572769514927 APP/ANO6/CALR/CD47/DOCK8/MIA3/PTK2/EPS8/GATA3/PLEC 10 GO:0002696 positive regulation of leukocyte activation 21/998 409/18722 0.602681798219491 0.806572769514927 CD46/DPP4/TFRC/SLC39A10/CD55/CD24/CD47/PRKDC/IL6ST/VAV3/HSPD1/GLI3/DOCK8/YES1/RIF1/MMP14/GATA3/BCL2/FLOT2/SNX4/PNP 21 GO:0002699 positive regulation of immune effector process 12/998 235/18722 0.602757230949906 0.806572769514927 CD46/TFRC/CADM1/CD55/HSPD1/ANKRD17/RIF1/DHX36/FZD5/DDX1/GATA3/SNX4 12 GO:1902600 proton transmembrane transport 8/998 157/18722 0.603004194965589 0.806572769514927 ATP6V1C2/ATP6V1B1/SLC9A1/ACTN4/CYB5A/SLC17A5/UQCRC1/COX6A1 8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 4/998 78/18722 0.603152569730672 0.806572769514927 HSPD1/PPARG/VCP/PMAIP1 4 GO:0019319 hexose biosynthetic process 4/998 78/18722 0.603152569730672 0.806572769514927 DDB1/SLC35B4/FAM3C/RANBP2 4 GO:0032024 positive regulation of insulin secretion 4/998 78/18722 0.603152569730672 0.806572769514927 GJA1/LRP1/ISL1/TCF7L2 4 GO:0035050 embryonic heart tube development 4/998 78/18722 0.603152569730672 0.806572769514927 YAP1/FOLR1/AHI1/CTNNB1 4 GO:0001819 positive regulation of cytokine production 24/998 467/18722 0.603863682828737 0.806572769514927 APP/CD46/CADM1/CD55/LRP1/IL6ST/HSPD1/ISL1/FERMT1/TLR3/PLA2R1/SETD2/HSP90AA1/MAPK14/DHX36/FZD5/DDX1/GATA3/SPTBN1/HSPA1B/HILPDA/TMF1/HDAC2/PNP 24 GO:0019439 aromatic compound catabolic process 24/998 467/18722 0.603863682828737 0.806572769514927 KCNQ1OT1/NUDT4/LIN28B/FUS/PON2/SND1/TTC37/TET2/PUM1/LRPPRC/DCP2/SMPDL3A/FMR1/DICER1/VCP/MAPK14/DHX36/AGO2/TNRC6A/HSPA1B/SECISBP2/ZC3H14/PNP/HNRNPU 24 GO:0006826 iron ion transport 3/998 58/18722 0.6039115174034 0.806572769514927 TFRC/SLC40A1/CLTC 3 GO:0007131 reciprocal meiotic recombination 3/998 58/18722 0.6039115174034 0.806572769514927 RAD50/TOP2B/RAD21 3 GO:0009161 ribonucleoside monophosphate metabolic process 3/998 58/18722 0.6039115174034 0.806572769514927 DLG1/AK3/PNP 3 GO:0043525 positive regulation of neuron apoptotic process 3/998 58/18722 0.6039115174034 0.806572769514927 NF1/TFAP2A/CTNNB1 3 GO:0140527 reciprocal homologous recombination 3/998 58/18722 0.6039115174034 0.806572769514927 RAD50/TOP2B/RAD21 3 GO:0043473 pigmentation 5/998 98/18722 0.60404372244993 0.806572769514927 NF1/GLI3/MYO7A/HPS5/BCL2 5 GO:1903313 positive regulation of mRNA metabolic process 6/998 118/18722 0.605736592207493 0.806572769514927 PUM1/DCP2/TRA2B/DHX36/AGO2/TNRC6A 6 GO:0001675 acrosome assembly 1/998 17/18722 0.606102013591461 0.806572769514927 TMF1 1 GO:0001829 trophectodermal cell differentiation 1/998 17/18722 0.606102013591461 0.806572769514927 YAP1 1 GO:0003184 pulmonary valve morphogenesis 1/998 17/18722 0.606102013591461 0.806572769514927 GJA5 1 GO:0006390 mitochondrial transcription 1/998 17/18722 0.606102013591461 0.806572769514927 TFAM 1 GO:0006895 Golgi to endosome transport 1/998 17/18722 0.606102013591461 0.806572769514927 VPS13A 1 GO:0007351 tripartite regional subdivision 1/998 17/18722 0.606102013591461 0.806572769514927 FZD5 1 GO:0008334 histone mRNA metabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 DCP2 1 GO:0008595 anterior/posterior axis specification, embryo 1/998 17/18722 0.606102013591461 0.806572769514927 FZD5 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 PNP 1 GO:0014856 skeletal muscle cell proliferation 1/998 17/18722 0.606102013591461 0.806572769514927 PAXBP1 1 GO:0020027 hemoglobin metabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 EIF2AK1 1 GO:0021513 spinal cord dorsal/ventral patterning 1/998 17/18722 0.606102013591461 0.806572769514927 GLI3 1 GO:0030322 stabilization of membrane potential 1/998 17/18722 0.606102013591461 0.806572769514927 KCNN4 1 GO:0031573 mitotic intra-S DNA damage checkpoint signaling 1/998 17/18722 0.606102013591461 0.806572769514927 XPC 1 GO:0032048 cardiolipin metabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 HADHA 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/998 17/18722 0.606102013591461 0.806572769514927 LEPROT 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/998 17/18722 0.606102013591461 0.806572769514927 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/998 17/18722 0.606102013591461 0.806572769514927 ISL1 1 GO:0034349 glial cell apoptotic process 1/998 17/18722 0.606102013591461 0.806572769514927 PRKCI 1 GO:0035518 histone H2A monoubiquitination 1/998 17/18722 0.606102013591461 0.806572769514927 DDB1 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/998 17/18722 0.606102013591461 0.806572769514927 NRP1 1 GO:0035855 megakaryocyte development 1/998 17/18722 0.606102013591461 0.806572769514927 WASF2 1 GO:0036065 fucosylation 1/998 17/18722 0.606102013591461 0.806572769514927 FUT8 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/998 17/18722 0.606102013591461 0.806572769514927 PIK3CB 1 GO:0036166 phenotypic switching 1/998 17/18722 0.606102013591461 0.806572769514927 DNMT1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/998 17/18722 0.606102013591461 0.806572769514927 SUZ12 1 GO:0043649 dicarboxylic acid catabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 QPRT 1 GO:0043968 histone H2A acetylation 1/998 17/18722 0.606102013591461 0.806572769514927 BRD8 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/998 17/18722 0.606102013591461 0.806572769514927 CD46 1 GO:0048339 paraxial mesoderm development 1/998 17/18722 0.606102013591461 0.806572769514927 YAP1 1 GO:0051580 regulation of neurotransmitter uptake 1/998 17/18722 0.606102013591461 0.806572769514927 ITGB1 1 GO:0051797 regulation of hair follicle development 1/998 17/18722 0.606102013591461 0.806572769514927 FERMT1 1 GO:0055003 cardiac myofibril assembly 1/998 17/18722 0.606102013591461 0.806572769514927 OBSL1 1 GO:0060033 anatomical structure regression 1/998 17/18722 0.606102013591461 0.806572769514927 LRP5 1 GO:0060644 mammary gland epithelial cell differentiation 1/998 17/18722 0.606102013591461 0.806572769514927 IRF6 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/998 17/18722 0.606102013591461 0.806572769514927 DHX36 1 GO:0070206 protein trimerization 1/998 17/18722 0.606102013591461 0.806572769514927 SLC1A5 1 GO:0070593 dendrite self-avoidance 1/998 17/18722 0.606102013591461 0.806572769514927 BSG 1 GO:0070875 positive regulation of glycogen metabolic process 1/998 17/18722 0.606102013591461 0.806572769514927 SORBS1 1 GO:0090036 regulation of protein kinase C signaling 1/998 17/18722 0.606102013591461 0.806572769514927 GPD1L 1 GO:0090083 regulation of inclusion body assembly 1/998 17/18722 0.606102013591461 0.806572769514927 HSPA1B 1 GO:0090713 immunological memory process 1/998 17/18722 0.606102013591461 0.806572769514927 CD46 1 GO:1900034 regulation of cellular response to heat 1/998 17/18722 0.606102013591461 0.806572769514927 GSK3B 1 GO:1900363 regulation of mRNA polyadenylation 1/998 17/18722 0.606102013591461 0.806572769514927 ZC3H14 1 GO:1901550 regulation of endothelial cell development 1/998 17/18722 0.606102013591461 0.806572769514927 S1PR2 1 GO:1903140 regulation of establishment of endothelial barrier 1/998 17/18722 0.606102013591461 0.806572769514927 S1PR2 1 GO:0007224 smoothened signaling pathway 7/998 138/18722 0.607853612026161 0.806572769514927 DLG5/GLI3/VCP/FGFR2/HERC4/GPC3/CTNNA1 7 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 7/998 138/18722 0.607853612026161 0.806572769514927 HSPA5/SKP2/PTTG1IP/HUWE1/NDFIP2/MYCBP2/VCP 7 GO:0006417 regulation of translation 24/998 468/18722 0.608104237295524 0.806572769514927 APP/IGF2BP3/CALR/PRKDC/EIF2AK1/TPR/PUM1/LRPPRC/DCP2/EIF4G1/FMR1/PURA/EIF2AK4/LARP4/NEMF/DHX36/DDX1/AGO2/ACO1/TNRC6A/ATXN2/SECISBP2/QKI/TIA1 24 GO:0001825 blastocyst formation 2/998 38/18722 0.608665584243407 0.806572769514927 YAP1/RTN4 2 GO:0002478 antigen processing and presentation of exogenous peptide antigen 2/998 38/18722 0.608665584243407 0.806572769514927 CTSL/CTSV 2 GO:0007007 inner mitochondrial membrane organization 2/998 38/18722 0.608665584243407 0.806572769514927 AFG3L2/HSPA9 2 GO:0008210 estrogen metabolic process 2/998 38/18722 0.608665584243407 0.806572769514927 HSD17B1/PLEKHA1 2 GO:0010719 negative regulation of epithelial to mesenchymal transition 2/998 38/18722 0.608665584243407 0.806572769514927 EFNA1/GATA3 2 GO:0030279 negative regulation of ossification 2/998 38/18722 0.608665584243407 0.806572769514927 BCL2/LTBP3 2 GO:0032941 secretion by tissue 2/998 38/18722 0.608665584243407 0.806572769514927 EGFR/KCNN4 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/998 38/18722 0.608665584243407 0.806572769514927 DNMT1/PDCD4 2 GO:0046329 negative regulation of JNK cascade 2/998 38/18722 0.608665584243407 0.806572769514927 MARVELD3/PDCD4 2 GO:0071392 cellular response to estradiol stimulus 2/998 38/18722 0.608665584243407 0.806572769514927 EGFR/NCOA3 2 GO:0072524 pyridine-containing compound metabolic process 2/998 38/18722 0.608665584243407 0.806572769514927 QPRT/PNP 2 GO:0099622 cardiac muscle cell membrane repolarization 2/998 38/18722 0.608665584243407 0.806572769514927 AKAP9/GJA5 2 GO:1903580 positive regulation of ATP metabolic process 2/998 38/18722 0.608665584243407 0.806572769514927 APP/VCP 2 GO:1903725 regulation of phospholipid metabolic process 2/998 38/18722 0.608665584243407 0.806572769514927 IDH1/ACSL3 2 GO:0030072 peptide hormone secretion 12/998 236/18722 0.608675868969319 0.806572769514927 EGFR/DPP4/GJA1/LRP5/FAM3B/LRP1/CCDC186/CAMK2G/ISL1/SYT7/SLC16A1/TCF7L2 12 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 5/998 99/18722 0.613089419980268 0.811391599928258 PRKDC/USP47/TP63/BCL2/SHISA5 5 GO:0021510 spinal cord development 5/998 99/18722 0.613089419980268 0.811391599928258 LMO4/NF1/ISL1/GLI3/SUZ12 5 GO:0021549 cerebellum development 5/998 99/18722 0.613089419980268 0.811391599928258 HSPA5/RERE/NCSTN/SDF4/OPHN1 5 GO:0033209 tumor necrosis factor-mediated signaling pathway 5/998 99/18722 0.613089419980268 0.811391599928258 SPPL2A/ACTN4/SPPL2B/HSPA1B/KRT18 5 GO:0051153 regulation of striated muscle cell differentiation 5/998 99/18722 0.613089419980268 0.811391599928258 MAPK14/BHLHE41/MMP14/BCL2/YY1 5 GO:1901184 regulation of ERBB signaling pathway 4/998 79/18722 0.613266911895406 0.811412011239205 EGFR/IFI6/RTN4/ERRFI1 4 GO:0062012 regulation of small molecule metabolic process 17/998 334/18722 0.613415669098093 0.811412011239205 APP/DDB1/PARP1/SLC35B4/ATP2B4/LPCAT3/ACADVL/CLN3/MBTPS1/SORBS1/PPARG/VCP/FAM3C/RANBP2/GSK3B/PMAIP1/PHLDA2 17 GO:0031398 positive regulation of protein ubiquitination 6/998 119/18722 0.613988926757928 0.811964586272326 HSPA5/SKP2/PTTG1IP/HUWE1/NDFIP2/MYCBP2 6 GO:0051783 regulation of nuclear division 7/998 139/18722 0.615486569449647 0.813655647160988 BMP7/LRP5/CALR/OBSL1/TPR/RAD21/ANAPC5 7 GO:0051353 positive regulation of oxidoreductase activity 3/998 59/18722 0.615579353818407 0.813655647160988 PIK3CB/KRAS/PDP2 3 GO:0001936 regulation of endothelial cell proliferation 9/998 179/18722 0.619398165354582 0.815285059437481 NRP2/NRP1/GJA1/NR2F2/NF1/TGFBR1/PPARG/PTPRM/EMC10 9 GO:0051259 protein complex oligomerization 12/998 238/18722 0.620386925765499 0.815285059437481 FUS/SLC9A1/TP63/HOMER1/SLC1A5/TRPM7/HGSNAT/GOLGA2/ALDH1A3/KCTD3/ALAD/YME1L1 12 GO:0071774 response to fibroblast growth factor 6/998 120/18722 0.622143851679658 0.815285059437481 KDM5B/FGFR2/CTNNB1/GATA3/EXT2/GPC1 6 GO:0002347 response to tumor cell 2/998 39/18722 0.622906134682742 0.815285059437481 HSPD1/RBMS3 2 GO:0021587 cerebellum morphogenesis 2/998 39/18722 0.622906134682742 0.815285059437481 HSPA5/OPHN1 2 GO:0032728 positive regulation of interferon-beta production 2/998 39/18722 0.622906134682742 0.815285059437481 TLR3/HSP90AA1 2 GO:0045823 positive regulation of heart contraction 2/998 39/18722 0.622906134682742 0.815285059437481 ADRB1/ATP2A2 2 GO:0051154 negative regulation of striated muscle cell differentiation 2/998 39/18722 0.622906134682742 0.815285059437481 BHLHE41/YY1 2 GO:1901861 regulation of muscle tissue development 2/998 39/18722 0.622906134682742 0.815285059437481 CTNNB1/BCL2 2 GO:0051303 establishment of chromosome localization 4/998 80/18722 0.623219944898032 0.815285059437481 EML4/DYNC1H1/SUN1/HNRNPU 4 GO:0009746 response to hexose 11/998 219/18722 0.623861794509542 0.815285059437481 SERPINF1/GJA1/LRP5/IGF1R/LRP1/CTSV/CCDC186/TRA2B/TCF7L2/SLC29A1/KRT18 11 GO:0002253 activation of immune response 19/998 375/18722 0.62405555578557 0.815285059437481 CD46/SLC39A10/CD55/CD47/PRKDC/KCNN4/VAV3/SFPQ/PAWR/YES1/EZR/CD59/HSP90AA1/PLEKHA1/PTK2/GATA3/BCL2/SPPL3/HEXIM1 19 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 3/998 60/18722 0.627012701809732 0.815285059437481 PUM1/ANKRD17/HSPA1B 3 GO:0006289 nucleotide-excision repair 3/998 60/18722 0.627012701809732 0.815285059437481 DDB1/RAD23B/XPC 3 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 3/998 60/18722 0.627012701809732 0.815285059437481 FOXO4/USP47/RAD21 3 GO:0030071 regulation of mitotic metaphase/anaphase transition 3/998 60/18722 0.627012701809732 0.815285059437481 TPR/RAD21/ANAPC5 3 GO:0035825 homologous recombination 3/998 60/18722 0.627012701809732 0.815285059437481 RAD50/TOP2B/RAD21 3 GO:0051965 positive regulation of synapse assembly 3/998 60/18722 0.627012701809732 0.815285059437481 DLG5/TPBG/CLSTN1 3 GO:0000712 resolution of meiotic recombination intermediates 1/998 18/18722 0.627118329573056 0.815285059437481 TOP2B 1 GO:0001946 lymphangiogenesis 1/998 18/18722 0.627118329573056 0.815285059437481 PTPN14 1 GO:0002076 osteoblast development 1/998 18/18722 0.627118329573056 0.815285059437481 LRP5 1 GO:0002283 neutrophil activation involved in immune response 1/998 18/18722 0.627118329573056 0.815285059437481 ANXA3 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/998 18/18722 0.627118329573056 0.815285059437481 CALR 1 GO:0002544 chronic inflammatory response 1/998 18/18722 0.627118329573056 0.815285059437481 GJA1 1 GO:0006085 acetyl-CoA biosynthetic process 1/998 18/18722 0.627118329573056 0.815285059437481 ACSS1 1 GO:0006103 2-oxoglutarate metabolic process 1/998 18/18722 0.627118329573056 0.815285059437481 IDH1 1 GO:0006337 nucleosome disassembly 1/998 18/18722 0.627118329573056 0.815285059437481 SMARCC1 1 GO:0006991 response to sterol depletion 1/998 18/18722 0.627118329573056 0.815285059437481 LPCAT3 1 GO:0007250 activation of NF-kappaB-inducing kinase activity 1/998 18/18722 0.627118329573056 0.815285059437481 TLR3 1 GO:0009125 nucleoside monophosphate catabolic process 1/998 18/18722 0.627118329573056 0.815285059437481 PNP 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/998 18/18722 0.627118329573056 0.815285059437481 AK3 1 GO:0015732 prostaglandin transport 1/998 18/18722 0.627118329573056 0.815285059437481 P2RX4 1 GO:0015936 coenzyme A metabolic process 1/998 18/18722 0.627118329573056 0.815285059437481 CROT 1 GO:0019184 nonribosomal peptide biosynthetic process 1/998 18/18722 0.627118329573056 0.815285059437481 NFE2L2 1 GO:0019896 axonal transport of mitochondrion 1/998 18/18722 0.627118329573056 0.815285059437481 ARMCX3 1 GO:0021511 spinal cord patterning 1/998 18/18722 0.627118329573056 0.815285059437481 GLI3 1 GO:0030206 chondroitin sulfate biosynthetic process 1/998 18/18722 0.627118329573056 0.815285059437481 CHPF 1 GO:0030728 ovulation 1/998 18/18722 0.627118329573056 0.815285059437481 ADAMTS1 1 GO:0030730 sequestering of triglyceride 1/998 18/18722 0.627118329573056 0.815285059437481 PPARG 1 GO:0030889 negative regulation of B cell proliferation 1/998 18/18722 0.627118329573056 0.815285059437481 PAWR 1 GO:0031000 response to caffeine 1/998 18/18722 0.627118329573056 0.815285059437481 HDAC2 1 GO:0031649 heat generation 1/998 18/18722 0.627118329573056 0.815285059437481 ADRB1 1 GO:0032634 interleukin-5 production 1/998 18/18722 0.627118329573056 0.815285059437481 GATA3 1 GO:0032674 regulation of interleukin-5 production 1/998 18/18722 0.627118329573056 0.815285059437481 GATA3 1 GO:0032769 negative regulation of monooxygenase activity 1/998 18/18722 0.627118329573056 0.815285059437481 ATP2B4 1 GO:0033189 response to vitamin A 1/998 18/18722 0.627118329573056 0.815285059437481 DNMT3A 1 GO:0034162 toll-like receptor 9 signaling pathway 1/998 18/18722 0.627118329573056 0.815285059437481 RTN4 1 GO:0035372 protein localization to microtubule 1/998 18/18722 0.627118329573056 0.815285059437481 HNRNPU 1 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 1/998 18/18722 0.627118329573056 0.815285059437481 GATA3 1 GO:0042136 neurotransmitter biosynthetic process 1/998 18/18722 0.627118329573056 0.815285059437481 SLC6A4 1 GO:0043116 negative regulation of vascular permeability 1/998 18/18722 0.627118329573056 0.815285059437481 FERMT2 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/998 18/18722 0.627118329573056 0.815285059437481 ADRB1 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/998 18/18722 0.627118329573056 0.815285059437481 SYT7 1 GO:0046040 IMP metabolic process 1/998 18/18722 0.627118329573056 0.815285059437481 PNP 1 GO:0055070 copper ion homeostasis 1/998 18/18722 0.627118329573056 0.815285059437481 APP 1 GO:0060192 negative regulation of lipase activity 1/998 18/18722 0.627118329573056 0.815285059437481 PLA2R1 1 GO:0060438 trachea development 1/998 18/18722 0.627118329573056 0.815285059437481 CTNNB1 1 GO:0060716 labyrinthine layer blood vessel development 1/998 18/18722 0.627118329573056 0.815285059437481 FZD5 1 GO:0072189 ureter development 1/998 18/18722 0.627118329573056 0.815285059437481 GATA3 1 GO:0080182 histone H3-K4 trimethylation 1/998 18/18722 0.627118329573056 0.815285059437481 TET2 1 GO:0110154 RNA decapping 1/998 18/18722 0.627118329573056 0.815285059437481 DCP2 1 GO:1902074 response to salt 1/998 18/18722 0.627118329573056 0.815285059437481 HSPA5 1 GO:1902170 cellular response to reactive nitrogen species 1/998 18/18722 0.627118329573056 0.815285059437481 MTR 1 GO:1902683 regulation of receptor localization to synapse 1/998 18/18722 0.627118329573056 0.815285059437481 DAG1 1 GO:1904872 regulation of telomerase RNA localization to Cajal body 1/998 18/18722 0.627118329573056 0.815285059437481 DCP2 1 GO:1905820 positive regulation of chromosome separation 1/998 18/18722 0.627118329573056 0.815285059437481 ANAPC5 1 GO:0002224 toll-like receptor signaling pathway 6/998 121/18722 0.630199548049193 0.819086841016888 COLEC12/LGR4/HSPD1/TLR3/RTN4/OTUD4 6 GO:0016241 regulation of macroautophagy 7/998 141/18722 0.630507699703306 0.81927286488318 EXOC1/ATP6V1C2/ATP6V1B1/CLN3/NEDD4/UVRAG/VPS35 7 GO:0006476 protein deacetylation 5/998 101/18722 0.630813429770232 0.81927286488318 TBL1X/RCOR1/SFPQ/NIPBL/HDAC2 5 GO:0006576 cellular biogenic amine metabolic process 5/998 101/18722 0.630813429770232 0.81927286488318 ALDH7A1/SLC44A1/SMS/AZIN1/GATA3 5 GO:0032640 tumor necrosis factor production 9/998 181/18722 0.632645414697897 0.820695798540105 APP/CD47/HSPD1/ISL1/TLR3/DICER1/ERRFI1/FZD5/HDAC2 9 GO:0032680 regulation of tumor necrosis factor production 9/998 181/18722 0.632645414697897 0.820695798540105 APP/CD47/HSPD1/ISL1/TLR3/DICER1/ERRFI1/FZD5/HDAC2 9 GO:0097696 receptor signaling pathway via STAT 9/998 181/18722 0.632645414697897 0.820695798540105 PRLR/IL10RB/IL6ST/ISL1/LEPROT/SUZ12/PPARG/HDAC2/OCIAD1 9 GO:0099504 synaptic vesicle cycle 9/998 181/18722 0.632645414697897 0.820695798540105 CANX/SYT7/STON1/KIAA1109/FMR1/CTNNB1/ATP2A2/GSK3B/OPHN1 9 GO:0001523 retinoid metabolic process 4/998 81/18722 0.633009381482667 0.820695798540105 LRP2/LRP1/ADH5/ALDH1A3 4 GO:0051149 positive regulation of muscle cell differentiation 4/998 81/18722 0.633009381482667 0.820695798540105 MDM2/MAPK14/MMP14/BCL2 4 GO:2000106 regulation of leukocyte apoptotic process 4/998 81/18722 0.633009381482667 0.820695798540105 SLC39A10/EFNA1/DOCK8/PIK3CB 4 GO:0007204 positive regulation of cytosolic calcium ion concentration 16/998 319/18722 0.635533451849869 0.8234905828168 ITGAV/GJA1/CD55/TGM2/LRP1/CD24/ATP2B4/MCOLN3/DMD/TRPV6/P2RX4/SWAP70/BCAP31/GPR157/BCL2/SPPL3 16 GO:0002714 positive regulation of B cell mediated immunity 2/998 40/18722 0.636742287460529 0.8234905828168 TFRC/RIF1 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/998 40/18722 0.636742287460529 0.8234905828168 TFRC/RIF1 2 GO:0031297 replication fork processing 2/998 40/18722 0.636742287460529 0.8234905828168 ATRX/BOD1L1 2 GO:0032094 response to food 2/998 40/18722 0.636742287460529 0.8234905828168 SLC16A1/PLEC 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/998 40/18722 0.636742287460529 0.8234905828168 LGR4/OTUD4 2 GO:0045740 positive regulation of DNA replication 2/998 40/18722 0.636742287460529 0.8234905828168 EGFR/ATRX 2 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/998 40/18722 0.636742287460529 0.8234905828168 TPR/RAD21 2 GO:0055081 anion homeostasis 2/998 40/18722 0.636742287460529 0.8234905828168 SLC12A9/ATP6V1B1 2 GO:0070266 necroptotic process 2/998 40/18722 0.636742287460529 0.8234905828168 TLR3/TRPM7 2 GO:0006813 potassium ion transport 12/998 241/18722 0.637624586088221 0.823884543559701 AKAP9/ITGB1/DLG1/GJA5/FXYD3/ANO6/ANK3/KCNN4/SLC12A9/SLC9A1/NEDD4/SLC1A3 12 GO:0046467 membrane lipid biosynthetic process 7/998 142/18722 0.637892840833696 0.823884543559701 DEGS1/ORMDL1/HACD3/PGAP1/PLPP3/SPTLC3/SGPP1 7 GO:0002688 regulation of leukocyte chemotaxis 6/998 122/18722 0.638154340821693 0.823884543559701 DPP4/ANO6/CALR/SWAP70/JAM3/PTK2 6 GO:1990266 neutrophil migration 6/998 122/18722 0.638154340821693 0.823884543559701 CSF3R/DPP4/VAV3/BSG/JAM3/PPIB 6 GO:0060997 dendritic spine morphogenesis 3/998 61/18722 0.638209692132834 0.823884543559701 PPP1R9A/EFNA1/DHX36 3 GO:1905515 non-motile cilium assembly 3/998 61/18722 0.638209692132834 0.823884543559701 ATMIN/PCM1/MAP4 3 GO:2000401 regulation of lymphocyte migration 3/998 61/18722 0.638209692132834 0.823884543559701 APP/DOCK8/MIA3 3 GO:0060759 regulation of response to cytokine stimulus 8/998 162/18722 0.638309323635126 0.823884543559701 CD24/SPPL2A/TRIM44/PTPN1/PPARG/SPPL2B/HSPA1B/OTUD4 8 GO:0060401 cytosolic calcium ion transport 9/998 182/18722 0.639175010726327 0.824125340389376 ATP2B1/ATP2B4/MCOLN3/DMD/TRPV6/AFG3L2/P2RX4/BCL2/ATP2A2 9 GO:1902106 negative regulation of leukocyte differentiation 5/998 102/18722 0.639487763437782 0.824125340389376 FBN1/CDK6/GLI3/TLR3/CTNNB1 5 GO:1990542 mitochondrial transmembrane transport 5/998 102/18722 0.639487763437782 0.824125340389376 HSPD1/SLC25A36/AFG3L2/CPT2/TOMM20 5 GO:0016042 lipid catabolic process 16/998 320/18722 0.640483347001064 0.824125340389376 STS/SLC27A2/LRP1/IDH1/HADHA/HEXB/FUCA1/CROT/ECHDC2/ACADVL/ECI2/CPT2/HEXA/GM2A/ECHDC1/ETFA 16 GO:0002312 B cell activation involved in immune response 4/998 82/18722 0.642633252478454 0.824125340389376 TFRC/HSPD1/SWAP70/RIF1 4 GO:0008543 fibroblast growth factor receptor signaling pathway 4/998 82/18722 0.642633252478454 0.824125340389376 FGFR2/CTNNB1/GATA3/GPC1 4 GO:0046364 monosaccharide biosynthetic process 4/998 82/18722 0.642633252478454 0.824125340389376 DDB1/SLC35B4/FAM3C/RANBP2 4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 4/998 82/18722 0.642633252478454 0.824125340389376 SND1/DICER1/AGO2/RPS21 4 GO:0006633 fatty acid biosynthetic process 8/998 163/18722 0.645155587755895 0.824125340389376 ACSS1/DEGS1/HACD3/ACADVL/ACSL3/FASN/QKI/TECR 8 GO:0071322 cellular response to carbohydrate stimulus 8/998 163/18722 0.645155587755895 0.824125340389376 COLEC12/SERPINF1/LRP5/IGF1R/LRP1/CCDC186/TRA2B/SLC29A1 8 GO:0070555 response to interleukin-1 7/998 143/18722 0.645192518350089 0.824125340389376 APP/CD47/RPS6KA5/USP10/PRKCI/OTUD4/YY1 7 GO:0002819 regulation of adaptive immune response 9/998 183/18722 0.645640487998483 0.824125340389376 CD46/TFRC/CD55/IL6ST/HSPD1/EIF2AK4/RIF1/FZD5/GATA3 9 GO:0030168 platelet activation 6/998 123/18722 0.646006695806923 0.824125340389376 IL6ST/VAV3/PIK3CB/FZD6/MAPK14/GNAS 6 GO:0000028 ribosomal small subunit assembly 1/998 19/18722 0.647014389618292 0.824125340389376 PRKDC 1 GO:0002396 MHC protein complex assembly 1/998 19/18722 0.647014389618292 0.824125340389376 CALR 1 GO:0002523 leukocyte migration involved in inflammatory response 1/998 19/18722 0.647014389618292 0.824125340389376 JAM3 1 GO:0002902 regulation of B cell apoptotic process 1/998 19/18722 0.647014389618292 0.824125340389376 SLC39A10 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/998 19/18722 0.647014389618292 0.824125340389376 ADRB1 1 GO:0006007 glucose catabolic process 1/998 19/18722 0.647014389618292 0.824125340389376 LRP5 1 GO:0006044 N-acetylglucosamine metabolic process 1/998 19/18722 0.647014389618292 0.824125340389376 EXTL2 1 GO:0006309 apoptotic DNA fragmentation 1/998 19/18722 0.647014389618292 0.824125340389376 DICER1 1 GO:0009081 branched-chain amino acid metabolic process 1/998 19/18722 0.647014389618292 0.824125340389376 BCAT1 1 GO:0010759 positive regulation of macrophage chemotaxis 1/998 19/18722 0.647014389618292 0.824125340389376 PTK2 1 GO:0019373 epoxygenase P450 pathway 1/998 19/18722 0.647014389618292 0.824125340389376 CYP2J2 1 GO:0030220 platelet formation 1/998 19/18722 0.647014389618292 0.824125340389376 PRKDC 1 GO:0031065 positive regulation of histone deacetylation 1/998 19/18722 0.647014389618292 0.824125340389376 NIPBL 1 GO:0032616 interleukin-13 production 1/998 19/18722 0.647014389618292 0.824125340389376 GATA3 1 GO:0032656 regulation of interleukin-13 production 1/998 19/18722 0.647014389618292 0.824125340389376 GATA3 1 GO:0033194 response to hydroperoxide 1/998 19/18722 0.647014389618292 0.824125340389376 OXR1 1 GO:0036344 platelet morphogenesis 1/998 19/18722 0.647014389618292 0.824125340389376 PRKDC 1 GO:0045019 negative regulation of nitric oxide biosynthetic process 1/998 19/18722 0.647014389618292 0.824125340389376 ATP2B4 1 GO:0045603 positive regulation of endothelial cell differentiation 1/998 19/18722 0.647014389618292 0.824125340389376 CTNNB1 1 GO:0045618 positive regulation of keratinocyte differentiation 1/998 19/18722 0.647014389618292 0.824125340389376 NCOA3 1 GO:0045821 positive regulation of glycolytic process 1/998 19/18722 0.647014389618292 0.824125340389376 APP 1 GO:0046033 AMP metabolic process 1/998 19/18722 0.647014389618292 0.824125340389376 AK3 1 GO:0046782 regulation of viral transcription 1/998 19/18722 0.647014389618292 0.824125340389376 HEXIM1 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/998 19/18722 0.647014389618292 0.824125340389376 NR2F6 1 GO:0051546 keratinocyte migration 1/998 19/18722 0.647014389618292 0.824125340389376 FERMT1 1 GO:0051957 positive regulation of amino acid transport 1/998 19/18722 0.647014389618292 0.824125340389376 ITGB1 1 GO:0070989 oxidative demethylation 1/998 19/18722 0.647014389618292 0.824125340389376 TET2 1 GO:0072074 kidney mesenchyme development 1/998 19/18722 0.647014389618292 0.824125340389376 BMP7 1 GO:0072077 renal vesicle morphogenesis 1/998 19/18722 0.647014389618292 0.824125340389376 CTNNB1 1 GO:0090670 RNA localization to Cajal body 1/998 19/18722 0.647014389618292 0.824125340389376 DCP2 1 GO:0090671 telomerase RNA localization to Cajal body 1/998 19/18722 0.647014389618292 0.824125340389376 DCP2 1 GO:0090672 telomerase RNA localization 1/998 19/18722 0.647014389618292 0.824125340389376 DCP2 1 GO:0090685 RNA localization to nucleus 1/998 19/18722 0.647014389618292 0.824125340389376 DCP2 1 GO:0097501 stress response to metal ion 1/998 19/18722 0.647014389618292 0.824125340389376 HSPA5 1 GO:0098780 response to mitochondrial depolarisation 1/998 19/18722 0.647014389618292 0.824125340389376 HUWE1 1 GO:1901659 glycosyl compound biosynthetic process 1/998 19/18722 0.647014389618292 0.824125340389376 PNP 1 GO:1901739 regulation of myoblast fusion 1/998 19/18722 0.647014389618292 0.824125340389376 MAPK14 1 GO:1904406 negative regulation of nitric oxide metabolic process 1/998 19/18722 0.647014389618292 0.824125340389376 ATP2B4 1 GO:2000042 negative regulation of double-strand break repair via homologous recombination 1/998 19/18722 0.647014389618292 0.824125340389376 RIF1 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/998 19/18722 0.647014389618292 0.824125340389376 NRP1 1 GO:0045639 positive regulation of myeloid cell differentiation 5/998 103/18722 0.64803466983364 0.824125340389376 PRKDC/SCIN/RCOR1/MAPK14/HSPA1B 5 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 5/998 103/18722 0.64803466983364 0.824125340389376 PRLR/IL10RB/LEPROT/SUZ12/OCIAD1 5 GO:0090277 positive regulation of peptide hormone secretion 5/998 103/18722 0.64803466983364 0.824125340389376 EGFR/GJA1/LRP1/ISL1/TCF7L2 5 GO:0043543 protein acylation 12/998 243/18722 0.648887481415934 0.824125340389376 NCOA3/ZNF451/ISL1/RPS6KA5/BRD7/ZDHHC17/PHF20/GATA3/USP22/GSK3B/BRD8/HDAC2 12 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3/998 62/18722 0.649168982644382 0.824125340389376 TPR/RAD21/ANAPC5 3 GO:0007588 excretion 3/998 62/18722 0.649168982644382 0.824125340389376 NFAT5/ATP6V1B1/CLN3 3 GO:0010573 vascular endothelial growth factor production 3/998 62/18722 0.649168982644382 0.824125340389376 ADGRG1/IL6ST/ISL1 3 GO:0032613 interleukin-10 production 3/998 62/18722 0.649168982644382 0.824125340389376 CD46/CD47/HSPD1 3 GO:0032653 regulation of interleukin-10 production 3/998 62/18722 0.649168982644382 0.824125340389376 CD46/CD47/HSPD1 3 GO:0032731 positive regulation of interleukin-1 beta production 3/998 62/18722 0.649168982644382 0.824125340389376 APP/ISL1/FZD5 3 GO:0046148 pigment biosynthetic process 3/998 62/18722 0.649168982644382 0.824125340389376 OPN3/NFE2L1/ALAD 3 GO:0048002 antigen processing and presentation of peptide antigen 3/998 62/18722 0.649168982644382 0.824125340389376 CTSL/CALR/CTSV 3 GO:1902750 negative regulation of cell cycle G2/M phase transition 3/998 62/18722 0.649168982644382 0.824125340389376 FOXO4/USP47/RAD21 3 GO:0007099 centriole replication 2/998 41/18722 0.65017664758932 0.824125340389376 CEP152/PLK2 2 GO:0032733 positive regulation of interleukin-10 production 2/998 41/18722 0.65017664758932 0.824125340389376 CD46/HSPD1 2 GO:0048634 regulation of muscle organ development 2/998 41/18722 0.65017664758932 0.824125340389376 CTNNB1/BCL2 2 GO:0060612 adipose tissue development 2/998 41/18722 0.65017664758932 0.824125340389376 LRP5/ARID5B 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/998 41/18722 0.65017664758932 0.824125340389376 DMD/ATP2A2 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/998 41/18722 0.65017664758932 0.824125340389376 PARP1/VCP 2 GO:1902622 regulation of neutrophil migration 2/998 41/18722 0.65017664758932 0.824125340389376 DPP4/JAM3 2 GO:1903524 positive regulation of blood circulation 2/998 41/18722 0.65017664758932 0.824125340389376 ADRB1/ATP2A2 2 GO:0050867 positive regulation of cell activation 21/998 420/18722 0.651184904589228 0.825203006519505 CD46/DPP4/TFRC/SLC39A10/CD55/CD24/CD47/PRKDC/IL6ST/VAV3/HSPD1/GLI3/DOCK8/YES1/RIF1/MMP14/GATA3/BCL2/FLOT2/SNX4/PNP 21 GO:2001257 regulation of cation channel activity 9/998 184/18722 0.652040848653202 0.825748565595049 APP/AHNAK/ITGB1/DLG1/ANK3/DMD/HOMER1/FMR1/STOM 9 GO:0031397 negative regulation of protein ubiquitination 4/998 83/18722 0.652089893880173 0.825748565595049 TRIM44/UFL1/UBR5/HSPA1B 4 GO:1901292 nucleoside phosphate catabolic process 4/998 83/18722 0.652089893880173 0.825748565595049 NUDT4/SMPDL3A/VCP/PNP 4 GO:1901890 positive regulation of cell junction assembly 5/998 104/18722 0.656452659564852 0.82850383066008 NRP1/DLG5/FERMT2/TPBG/CLSTN1 5 GO:0002040 sprouting angiogenesis 9/998 185/18722 0.658375155506894 0.82850383066008 SEMA6A/NRP1/ITGB1/EPHB4/TJP1/EPN2/MIA3/PIK3CB/PLK2 9 GO:0050796 regulation of insulin secretion 8/998 165/18722 0.658623913378342 0.82850383066008 DPP4/GJA1/LRP5/LRP1/ISL1/SYT7/SLC16A1/TCF7L2 8 GO:0034284 response to monosaccharide 11/998 225/18722 0.659150216654993 0.82850383066008 SERPINF1/GJA1/LRP5/IGF1R/LRP1/CTSV/CCDC186/TRA2B/TCF7L2/SLC29A1/KRT18 11 GO:0030239 myofibril assembly 3/998 63/18722 0.659889725540918 0.82850383066008 ITGB1/OBSL1/PLEC 3 GO:0099601 regulation of neurotransmitter receptor activity 3/998 63/18722 0.659889725540918 0.82850383066008 APP/AKAP9/HOMER1 3 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3/998 63/18722 0.659889725540918 0.82850383066008 TPR/RAD21/ANAPC5 3 GO:0042440 pigment metabolic process 4/998 84/18722 0.661377933954257 0.82850383066008 OPN3/NFE2L1/BCL2/ALAD 4 GO:0006040 amino sugar metabolic process 2/998 42/18722 0.663212690914068 0.82850383066008 EXTL2/GFPT1 2 GO:0009154 purine ribonucleotide catabolic process 2/998 42/18722 0.663212690914068 0.82850383066008 NUDT4/PNP 2 GO:0010677 negative regulation of cellular carbohydrate metabolic process 2/998 42/18722 0.663212690914068 0.82850383066008 FAM3C/GSK3B 2 GO:0021575 hindbrain morphogenesis 2/998 42/18722 0.663212690914068 0.82850383066008 HSPA5/OPHN1 2 GO:0030808 regulation of nucleotide biosynthetic process 2/998 42/18722 0.663212690914068 0.82850383066008 PARP1/VCP 2 GO:0042168 heme metabolic process 2/998 42/18722 0.663212690914068 0.82850383066008 NFE2L1/ALAD 2 GO:0045214 sarcomere organization 2/998 42/18722 0.663212690914068 0.82850383066008 ITGB1/PLEC 2 GO:0051602 response to electrical stimulus 2/998 42/18722 0.663212690914068 0.82850383066008 AKAP9/SLC9A1 2 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/998 42/18722 0.663212690914068 0.82850383066008 TPR/RAD21 2 GO:2000404 regulation of T cell migration 2/998 42/18722 0.663212690914068 0.82850383066008 APP/DOCK8 2 GO:0071706 tumor necrosis factor superfamily cytokine production 9/998 186/18722 0.664642531301551 0.82850383066008 APP/CD47/HSPD1/ISL1/TLR3/DICER1/ERRFI1/FZD5/HDAC2 9 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 9/998 186/18722 0.664642531301551 0.82850383066008 APP/CD47/HSPD1/ISL1/TLR3/DICER1/ERRFI1/FZD5/HDAC2 9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/998 20/18722 0.665849851264067 0.82850383066008 BRD4 1 GO:0002115 store-operated calcium entry 1/998 20/18722 0.665849851264067 0.82850383066008 HOMER1 1 GO:0002834 regulation of response to tumor cell 1/998 20/18722 0.665849851264067 0.82850383066008 HSPD1 1 GO:0002837 regulation of immune response to tumor cell 1/998 20/18722 0.665849851264067 0.82850383066008 HSPD1 1 GO:0003159 morphogenesis of an endothelium 1/998 20/18722 0.665849851264067 0.82850383066008 CTNNB1 1 GO:0006590 thyroid hormone generation 1/998 20/18722 0.665849851264067 0.82850383066008 GATA3 1 GO:0006607 NLS-bearing protein import into nucleus 1/998 20/18722 0.665849851264067 0.82850383066008 RANBP2 1 GO:0006837 serotonin transport 1/998 20/18722 0.665849851264067 0.82850383066008 SLC6A4 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/998 20/18722 0.665849851264067 0.82850383066008 AFG3L2 1 GO:0006896 Golgi to vacuole transport 1/998 20/18722 0.665849851264067 0.82850383066008 CLN3 1 GO:0007194 negative regulation of adenylate cyclase activity 1/998 20/18722 0.665849851264067 0.82850383066008 AKAP9 1 GO:0007620 copulation 1/998 20/18722 0.665849851264067 0.82850383066008 SLC6A4 1 GO:0009713 catechol-containing compound biosynthetic process 1/998 20/18722 0.665849851264067 0.82850383066008 GATA3 1 GO:0010523 negative regulation of calcium ion transport into cytosol 1/998 20/18722 0.665849851264067 0.82850383066008 BCL2 1 GO:0014047 glutamate secretion 1/998 20/18722 0.665849851264067 0.82850383066008 GJA1 1 GO:0016553 base conversion or substitution editing 1/998 20/18722 0.665849851264067 0.82850383066008 RBM47 1 GO:0017121 plasma membrane phospholipid scrambling 1/998 20/18722 0.665849851264067 0.82850383066008 ANO6 1 GO:0021516 dorsal spinal cord development 1/998 20/18722 0.665849851264067 0.82850383066008 LMO4 1 GO:0030150 protein import into mitochondrial matrix 1/998 20/18722 0.665849851264067 0.82850383066008 TOMM20 1 GO:0031498 chromatin disassembly 1/998 20/18722 0.665849851264067 0.82850383066008 SMARCC1 1 GO:0032332 positive regulation of chondrocyte differentiation 1/998 20/18722 0.665849851264067 0.82850383066008 GLI3 1 GO:0032495 response to muramyl dipeptide 1/998 20/18722 0.665849851264067 0.82850383066008 MAPK14 1 GO:0032793 positive regulation of CREB transcription factor activity 1/998 20/18722 0.665849851264067 0.82850383066008 RPS6KA5 1 GO:0032930 positive regulation of superoxide anion generation 1/998 20/18722 0.665849851264067 0.82850383066008 EGFR 1 GO:0032986 protein-DNA complex disassembly 1/998 20/18722 0.665849851264067 0.82850383066008 SMARCC1 1 GO:0033005 positive regulation of mast cell activation 1/998 20/18722 0.665849851264067 0.82850383066008 SNX4 1 GO:0042359 vitamin D metabolic process 1/998 20/18722 0.665849851264067 0.82850383066008 LRP2 1 GO:0042423 catecholamine biosynthetic process 1/998 20/18722 0.665849851264067 0.82850383066008 GATA3 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/998 20/18722 0.665849851264067 0.82850383066008 AGO2 1 GO:0043011 myeloid dendritic cell differentiation 1/998 20/18722 0.665849851264067 0.82850383066008 ITGB8 1 GO:0043046 DNA methylation involved in gamete generation 1/998 20/18722 0.665849851264067 0.82850383066008 DNMT3A 1 GO:0043651 linoleic acid metabolic process 1/998 20/18722 0.665849851264067 0.82850383066008 CYP2J2 1 GO:0043691 reverse cholesterol transport 1/998 20/18722 0.665849851264067 0.82850383066008 ABCA1 1 GO:0043984 histone H4-K16 acetylation 1/998 20/18722 0.665849851264067 0.82850383066008 PHF20 1 GO:0048025 negative regulation of mRNA splicing, via spliceosome 1/998 20/18722 0.665849851264067 0.82850383066008 SRSF4 1 GO:0048670 regulation of collateral sprouting 1/998 20/18722 0.665849851264067 0.82850383066008 LRP1 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/998 20/18722 0.665849851264067 0.82850383066008 DHX36 1 GO:0061154 endothelial tube morphogenesis 1/998 20/18722 0.665849851264067 0.82850383066008 CTNNB1 1 GO:0061318 renal filtration cell differentiation 1/998 20/18722 0.665849851264067 0.82850383066008 CD24 1 GO:0071731 response to nitric oxide 1/998 20/18722 0.665849851264067 0.82850383066008 MTR 1 GO:0072087 renal vesicle development 1/998 20/18722 0.665849851264067 0.82850383066008 CTNNB1 1 GO:0072112 glomerular visceral epithelial cell differentiation 1/998 20/18722 0.665849851264067 0.82850383066008 CD24 1 GO:0072567 chemokine (C-X-C motif) ligand 2 production 1/998 20/18722 0.665849851264067 0.82850383066008 LRP1 1 GO:0090201 negative regulation of release of cytochrome c from mitochondria 1/998 20/18722 0.665849851264067 0.82850383066008 LMNA 1 GO:0097150 neuronal stem cell population maintenance 1/998 20/18722 0.665849851264067 0.82850383066008 PCM1 1 GO:0097320 plasma membrane tubulation 1/998 20/18722 0.665849851264067 0.82850383066008 FNBP1L 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/998 20/18722 0.665849851264067 0.82850383066008 FMR1 1 GO:1902004 positive regulation of amyloid-beta formation 1/998 20/18722 0.665849851264067 0.82850383066008 EFNA1 1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/998 20/18722 0.665849851264067 0.82850383066008 NFE2L2 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/998 20/18722 0.665849851264067 0.82850383066008 PTPN1 1 GO:1903817 negative regulation of voltage-gated potassium channel activity 1/998 20/18722 0.665849851264067 0.82850383066008 ANK3 1 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 1/998 20/18722 0.665849851264067 0.82850383066008 LRP1 1 GO:2000678 negative regulation of transcription regulatory region DNA binding 1/998 20/18722 0.665849851264067 0.82850383066008 MSX2 1 GO:0006749 glutathione metabolic process 3/998 64/18722 0.670371535627764 0.832103893516557 ARL6IP5/IDH1/NFE2L2 3 GO:0045670 regulation of osteoclast differentiation 3/998 64/18722 0.670371535627764 0.832103893516557 FBN1/TLR3/CTNNB1 3 GO:0048857 neural nucleus development 3/998 64/18722 0.670371535627764 0.832103893516557 HSPA5/BCL2/ALDH1A3 3 GO:0055002 striated muscle cell development 3/998 64/18722 0.670371535627764 0.832103893516557 ITGB1/OBSL1/PLEC 3 GO:0070542 response to fatty acid 3/998 64/18722 0.670371535627764 0.832103893516557 GLDC/ASS1/ALAD 3 GO:0098930 axonal transport 3/998 64/18722 0.670371535627764 0.832103893516557 DST/DYNC1H1/ARMCX3 3 GO:1903409 reactive oxygen species biosynthetic process 3/998 64/18722 0.670371535627764 0.832103893516557 SLC5A3/HSPD1/PAGE4 3 GO:0002709 regulation of T cell mediated immunity 4/998 85/18722 0.670496280410679 0.832103893516557 CD55/HSPD1/FZD5/GATA3 4 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 4/998 85/18722 0.670496280410679 0.832103893516557 IL6ST/ISL1/SUZ12/HDAC2 4 GO:0055072 iron ion homeostasis 4/998 85/18722 0.670496280410679 0.832103893516557 TFRC/SLC40A1/EIF2AK1/ACO1 4 GO:0071277 cellular response to calcium ion 4/998 85/18722 0.670496280410679 0.832103893516557 HSPA5/FUS/SYT7/NCSTN 4 GO:0055088 lipid homeostasis 8/998 167/18722 0.671786716581632 0.833507235568608 ORMDL1/LRP5/CD24/LIMA1/ABCA1/RTN4/PPARG/MYLIP 8 GO:0002793 positive regulation of peptide secretion 5/998 106/18722 0.67289687028332 0.834580204642453 EGFR/GJA1/LRP1/ISL1/TCF7L2 5 GO:0006284 base-excision repair 2/998 43/18722 0.675854664051509 0.834580204642453 USP47/HUWE1 2 GO:0021983 pituitary gland development 2/998 43/18722 0.675854664051509 0.834580204642453 CDH1/ISL1 2 GO:0031952 regulation of protein autophosphorylation 2/998 43/18722 0.675854664051509 0.834580204642453 RAD50/ERRFI1 2 GO:0033046 negative regulation of sister chromatid segregation 2/998 43/18722 0.675854664051509 0.834580204642453 TPR/RAD21 2 GO:0033048 negative regulation of mitotic sister chromatid segregation 2/998 43/18722 0.675854664051509 0.834580204642453 TPR/RAD21 2 GO:0035794 positive regulation of mitochondrial membrane permeability 2/998 43/18722 0.675854664051509 0.834580204642453 SLC9A1/GSK3B 2 GO:0045776 negative regulation of blood pressure 2/998 43/18722 0.675854664051509 0.834580204642453 ADRB1/GJA5 2 GO:0045840 positive regulation of mitotic nuclear division 2/998 43/18722 0.675854664051509 0.834580204642453 LRP5/ANAPC5 2 GO:0045981 positive regulation of nucleotide metabolic process 2/998 43/18722 0.675854664051509 0.834580204642453 APP/VCP 2 GO:0098815 modulation of excitatory postsynaptic potential 2/998 43/18722 0.675854664051509 0.834580204642453 APP/S1PR2 2 GO:1900544 positive regulation of purine nucleotide metabolic process 2/998 43/18722 0.675854664051509 0.834580204642453 APP/VCP 2 GO:2000816 negative regulation of mitotic sister chromatid separation 2/998 43/18722 0.675854664051509 0.834580204642453 TPR/RAD21 2 GO:0140694 non-membrane-bounded organelle assembly 18/998 367/18722 0.67650327533893 0.834580204642453 ITGB1/PRKDC/DYNC1H1/PRRC2C/CDS1/OBSL1/TPR/EZR/CEP152/GOLGA2/PLK2/PLEC/HSPA1B/ATXN2/STAG1/GPSM2/SQLE/HNRNPU 18 GO:0000070 mitotic sister chromatid segregation 8/998 168/18722 0.678251356325238 0.834580204642453 EML4/ATRX/TPR/RAD21/ANAPC5/PDS5A/NIPBL/HNRNPU 8 GO:0002706 regulation of lymphocyte mediated immunity 8/998 168/18722 0.678251356325238 0.834580204642453 CD46/TFRC/CADM1/CD55/HSPD1/RIF1/FZD5/GATA3 8 GO:0002833 positive regulation of response to biotic stimulus 8/998 168/18722 0.678251356325238 0.834580204642453 CADM1/PRKDC/HSPD1/PUM1/SFPQ/ANKRD17/HSP90AA1/HEXIM1 8 GO:0032413 negative regulation of ion transmembrane transporter activity 4/998 86/18722 0.679444107677385 0.834580204642453 ANK3/FMR1/NEDD4/GOPC 4 GO:0097530 granulocyte migration 7/998 148/18722 0.680368368913415 0.834580204642453 CSF3R/DPP4/VAV3/BSG/JAM3/PTK2/PPIB 7 GO:0010965 regulation of mitotic sister chromatid separation 3/998 65/18722 0.680614459652479 0.834580204642453 TPR/RAD21/ANAPC5 3 GO:0044784 metaphase/anaphase transition of cell cycle 3/998 65/18722 0.680614459652479 0.834580204642453 TPR/RAD21/ANAPC5 3 GO:0046513 ceramide biosynthetic process 3/998 65/18722 0.680614459652479 0.834580204642453 DEGS1/ORMDL1/SPTLC3 3 GO:0051310 metaphase plate congression 3/998 65/18722 0.680614459652479 0.834580204642453 EML4/DYNC1H1/HNRNPU 3 GO:0006275 regulation of DNA replication 5/998 107/18722 0.680921032609849 0.834580204642453 EGFR/ATRX/ANKRD17/WAPL/PDS5A 5 GO:0051341 regulation of oxidoreductase activity 5/998 107/18722 0.680921032609849 0.834580204642453 EGFR/ATP2B4/PIK3CB/KRAS/PDP2 5 GO:0071356 cellular response to tumor necrosis factor 11/998 229/18722 0.68161365103737 0.834580204642453 SPPL2A/ACTN4/MAPK14/SPPL2B/GATA3/ASS1/OCLN/HSPA1B/PRPF8/NFE2L2/KRT18 11 GO:0001502 cartilage condensation 1/998 21/18722 0.68368119809534 0.834580204642453 MAPK14 1 GO:0002689 negative regulation of leukocyte chemotaxis 1/998 21/18722 0.68368119809534 0.834580204642453 DPP4 1 GO:0003091 renal water homeostasis 1/998 21/18722 0.68368119809534 0.834580204642453 ATP6V1B1 1 GO:0003177 pulmonary valve development 1/998 21/18722 0.68368119809534 0.834580204642453 GJA5 1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 1/998 21/18722 0.68368119809534 0.834580204642453 COX6A1 1 GO:0006353 DNA-templated transcription, termination 1/998 21/18722 0.68368119809534 0.834580204642453 POLR2A 1 GO:0006450 regulation of translational fidelity 1/998 21/18722 0.68368119809534 0.834580204642453 IARS2 1 GO:0007289 spermatid nucleus differentiation 1/998 21/18722 0.68368119809534 0.834580204642453 TMF1 1 GO:0009070 serine family amino acid biosynthetic process 1/998 21/18722 0.68368119809534 0.834580204642453 SERINC3 1 GO:0010766 negative regulation of sodium ion transport 1/998 21/18722 0.68368119809534 0.834580204642453 NEDD4 1 GO:0019370 leukotriene biosynthetic process 1/998 21/18722 0.68368119809534 0.834580204642453 MGST3 1 GO:0021533 cell differentiation in hindbrain 1/998 21/18722 0.68368119809534 0.834580204642453 OPHN1 1 GO:0022010 central nervous system myelination 1/998 21/18722 0.68368119809534 0.834580204642453 NCSTN 1 GO:0023019 signal transduction involved in regulation of gene expression 1/998 21/18722 0.68368119809534 0.834580204642453 PARP1 1 GO:0030502 negative regulation of bone mineralization 1/998 21/18722 0.68368119809534 0.834580204642453 LTBP3 1 GO:0031145 anaphase-promoting complex-dependent catabolic process 1/998 21/18722 0.68368119809534 0.834580204642453 ANAPC5 1 GO:0032291 axon ensheathment in central nervous system 1/998 21/18722 0.68368119809534 0.834580204642453 NCSTN 1 GO:0032482 Rab protein signal transduction 1/998 21/18722 0.68368119809534 0.834580204642453 DENND4C 1 GO:0032516 positive regulation of phosphoprotein phosphatase activity 1/998 21/18722 0.68368119809534 0.834580204642453 SLC39A10 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/998 21/18722 0.68368119809534 0.834580204642453 FERMT1 1 GO:0034312 diol biosynthetic process 1/998 21/18722 0.68368119809534 0.834580204642453 SPTLC3 1 GO:0042454 ribonucleoside catabolic process 1/998 21/18722 0.68368119809534 0.834580204642453 PNP 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/998 21/18722 0.68368119809534 0.834580204642453 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/998 21/18722 0.68368119809534 0.834580204642453 SLC5A3 1 GO:0044342 type B pancreatic cell proliferation 1/998 21/18722 0.68368119809534 0.834580204642453 ERRFI1 1 GO:0045655 regulation of monocyte differentiation 1/998 21/18722 0.68368119809534 0.834580204642453 CDK6 1 GO:0045717 negative regulation of fatty acid biosynthetic process 1/998 21/18722 0.68368119809534 0.834580204642453 ACADVL 1 GO:0046128 purine ribonucleoside metabolic process 1/998 21/18722 0.68368119809534 0.834580204642453 PNP 1 GO:0046599 regulation of centriole replication 1/998 21/18722 0.68368119809534 0.834580204642453 PLK2 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/998 21/18722 0.68368119809534 0.834580204642453 CD55 1 GO:0046885 regulation of hormone biosynthetic process 1/998 21/18722 0.68368119809534 0.834580204642453 STC2 1 GO:0050802 circadian sleep/wake cycle, sleep 1/998 21/18722 0.68368119809534 0.834580204642453 ADRB1 1 GO:0060972 left/right pattern formation 1/998 21/18722 0.68368119809534 0.834580204642453 AHI1 1 GO:0070584 mitochondrion morphogenesis 1/998 21/18722 0.68368119809534 0.834580204642453 PLEC 1 GO:0072311 glomerular epithelial cell differentiation 1/998 21/18722 0.68368119809534 0.834580204642453 CD24 1 GO:0090026 positive regulation of monocyte chemotaxis 1/998 21/18722 0.68368119809534 0.834580204642453 ANO6 1 GO:0090141 positive regulation of mitochondrial fission 1/998 21/18722 0.68368119809534 0.834580204642453 VPS35 1 GO:0098719 sodium ion import across plasma membrane 1/998 21/18722 0.68368119809534 0.834580204642453 SLC9A1 1 GO:0150146 cell junction disassembly 1/998 21/18722 0.68368119809534 0.834580204642453 TGFBR1 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/998 21/18722 0.68368119809534 0.834580204642453 GSK3B 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/998 21/18722 0.68368119809534 0.834580204642453 ANK3 1 GO:1905209 positive regulation of cardiocyte differentiation 1/998 21/18722 0.68368119809534 0.834580204642453 DHX36 1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 1/998 21/18722 0.68368119809534 0.834580204642453 TJP1 1 GO:0030595 leukocyte chemotaxis 11/998 230/18722 0.687090606567491 0.838350095089711 CSF3R/DPP4/ANO6/CALR/VAV3/BSG/SWAP70/JAM3/PTK2/PLEC/PPIB 11 GO:0045055 regulated exocytosis 11/998 230/18722 0.687090606567491 0.838350095089711 SCIN/SYT7/TRPV6/FMR1/RAB31/RAB11FIP1/SDF4/ATP2A2/GSK3B/SNX4/ANXA3 11 GO:0006775 fat-soluble vitamin metabolic process 2/998 44/18722 0.688107492504831 0.838749072862777 LRP2/TTPA 2 GO:0030521 androgen receptor signaling pathway 2/998 44/18722 0.688107492504831 0.838749072862777 DDX17/TMF1 2 GO:0044058 regulation of digestive system process 2/998 44/18722 0.688107492504831 0.838749072862777 LPCAT3/SLC22A5 2 GO:0048066 developmental pigmentation 2/998 44/18722 0.688107492504831 0.838749072862777 GLI3/BCL2 2 GO:0001776 leukocyte homeostasis 4/998 87/18722 0.688220844310311 0.838749072862777 PIK3CB/JAM3/BCL2/PMAIP1 4 GO:0009566 fertilization 9/998 190/18722 0.68902723006766 0.839535861886406 CD46/NR2F2/SPESP1/ZFX/HEXB/ASH1L/FOLR1/B4GALT1/KDM5B 9 GO:0006303 double-strand break repair via nonhomologous end joining 3/998 66/18722 0.690618946727923 0.840298653196571 PRKDC/UVRAG/RIF1 3 GO:0030193 regulation of blood coagulation 3/998 66/18722 0.690618946727923 0.840298653196571 ANO6/NFE2L2/ANXA2 3 GO:0046626 regulation of insulin receptor signaling pathway 3/998 66/18722 0.690618946727923 0.840298653196571 KANK1/SORBS1/PTPN1 3 GO:0050918 positive chemotaxis 3/998 66/18722 0.690618946727923 0.840298653196571 MET/NRP1/LRP1 3 GO:0072678 T cell migration 3/998 66/18722 0.690618946727923 0.840298653196571 APP/DOCK8/PLEC 3 GO:2000272 negative regulation of signaling receptor activity 3/998 66/18722 0.690618946727923 0.840298653196571 LRPAP1/PPARG/ERRFI1 3 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/998 129/18722 0.690900652584721 0.840301722128417 ARL6IP5/HSPD1/PPARG/BCAP31/VCP/PMAIP1 6 GO:0007259 receptor signaling pathway via JAK-STAT 8/998 170/18722 0.690943362018252 0.840301722128417 PRLR/IL10RB/IL6ST/ISL1/LEPROT/SUZ12/HDAC2/OCIAD1 8 GO:0002456 T cell mediated immunity 5/998 109/18722 0.696569610668887 0.842772747466779 CD46/CD55/HSPD1/FZD5/GATA3 5 GO:0032410 negative regulation of transporter activity 5/998 109/18722 0.696569610668887 0.842772747466779 ANK3/NDFIP2/FMR1/NEDD4/GOPC 5 GO:0019932 second-messenger-mediated signaling 15/998 312/18722 0.69680093852718 0.842772747466779 EGFR/NFAT5/NUDT4/ATP2B4/DMD/PPP1R9A/SLC9A1/P2RX4/BCAP31/GNAI1/ADGRG6/ATP2A2/SPPL3/GSK3B/MCTP2 15 GO:0007260 tyrosine phosphorylation of STAT protein 4/998 88/18722 0.696826160568701 0.842772747466779 IL6ST/ISL1/SUZ12/HDAC2 4 GO:0046890 regulation of lipid biosynthetic process 8/998 171/18722 0.697169437918256 0.842772747466779 ORMDL1/IDH1/LPCAT3/SF1/ACADVL/MBTPS1/SORBS1/ACSL3 8 GO:0051048 negative regulation of secretion 8/998 171/18722 0.697169437918256 0.842772747466779 GJA1/FRMD4A/ERBB3/PPP1R9A/ERP29/FMR1/PLA2R1/RAB11FIP1 8 GO:0006887 exocytosis 17/998 352/18722 0.697580419492676 0.842772747466779 EXPH5/SCIN/SYT7/EXOC1/PRSS12/TRPV6/FMR1/MIA3/RAB31/RAB11FIP1/SDF4/ATP2A2/ARFGEF1/GSK3B/MICAL3/SNX4/ANXA3 17 GO:0009749 response to glucose 10/998 212/18722 0.699048000415292 0.842772747466779 SERPINF1/GJA1/LRP5/IGF1R/LRP1/CTSV/CCDC186/TRA2B/TCF7L2/SLC29A1 10 GO:0032309 icosanoid secretion 2/998 45/18722 0.699976696367742 0.842772747466779 PLA2R1/P2RX4 2 GO:0035307 positive regulation of protein dephosphorylation 2/998 45/18722 0.699976696367742 0.842772747466779 SLC39A10/SPPL3 2 GO:0044088 regulation of vacuole organization 2/998 45/18722 0.699976696367742 0.842772747466779 TMEM106B/ANXA2 2 GO:0046189 phenol-containing compound biosynthetic process 2/998 45/18722 0.699976696367742 0.842772747466779 OPN3/GATA3 2 GO:0051985 negative regulation of chromosome segregation 2/998 45/18722 0.699976696367742 0.842772747466779 TPR/RAD21 2 GO:0071354 cellular response to interleukin-6 2/998 45/18722 0.699976696367742 0.842772747466779 YAP1/IL6ST 2 GO:0098534 centriole assembly 2/998 45/18722 0.699976696367742 0.842772747466779 CEP152/PLK2 2 GO:1905819 negative regulation of chromosome separation 2/998 45/18722 0.699976696367742 0.842772747466779 TPR/RAD21 2 GO:0071333 cellular response to glucose stimulus 7/998 151/18722 0.700382731995776 0.842772747466779 SERPINF1/LRP5/IGF1R/LRP1/CCDC186/TRA2B/SLC29A1 7 GO:1904064 positive regulation of cation transmembrane transport 7/998 151/18722 0.700382731995776 0.842772747466779 AKAP9/ANO6/ANK3/KCNN4/DMD/SLC9A1/ACTN4 7 GO:0006879 cellular iron ion homeostasis 3/998 67/18722 0.700385819861735 0.842772747466779 TFRC/SLC40A1/ACO1 3 GO:0035914 skeletal muscle cell differentiation 3/998 67/18722 0.700385819861735 0.842772747466779 DDX17/KLF5/GPC1 3 GO:0042130 negative regulation of T cell proliferation 3/998 67/18722 0.700385819861735 0.842772747466779 DLG5/DLG1/PAWR 3 GO:0043967 histone H4 acetylation 3/998 67/18722 0.700385819861735 0.842772747466779 PHF20/USP22/BRD8 3 GO:0046635 positive regulation of alpha-beta T cell activation 3/998 67/18722 0.700385819861735 0.842772747466779 CD55/GLI3/PNP 3 GO:0051306 mitotic sister chromatid separation 3/998 67/18722 0.700385819861735 0.842772747466779 TPR/RAD21/ANAPC5 3 GO:0070527 platelet aggregation 3/998 67/18722 0.700385819861735 0.842772747466779 IL6ST/PIK3CB/GNAS 3 GO:1902117 positive regulation of organelle assembly 3/998 67/18722 0.700385819861735 0.842772747466779 DYNC1H1/ATMIN/GPSM2 3 GO:0002089 lens morphogenesis in camera-type eye 1/998 22/18722 0.700561908447773 0.842772747466779 CTNNB1 1 GO:0006379 mRNA cleavage 1/998 22/18722 0.700561908447773 0.842772747466779 AGO2 1 GO:0006907 pinocytosis 1/998 22/18722 0.700561908447773 0.842772747466779 CLN3 1 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1/998 22/18722 0.700561908447773 0.842772747466779 DMD 1 GO:0014821 phasic smooth muscle contraction 1/998 22/18722 0.700561908447773 0.842772747466779 DLG1 1 GO:0021904 dorsal/ventral neural tube patterning 1/998 22/18722 0.700561908447773 0.842772747466779 GLI3 1 GO:0022616 DNA strand elongation 1/998 22/18722 0.700561908447773 0.842772747466779 RAD50 1 GO:0030277 maintenance of gastrointestinal epithelium 1/998 22/18722 0.700561908447773 0.842772747466779 SLC22A5 1 GO:0031061 negative regulation of histone methylation 1/998 22/18722 0.700561908447773 0.842772747466779 DNMT1 1 GO:0034755 iron ion transmembrane transport 1/998 22/18722 0.700561908447773 0.842772747466779 SLC40A1 1 GO:0035561 regulation of chromatin binding 1/998 22/18722 0.700561908447773 0.842772747466779 WAPL 1 GO:0035584 calcium-mediated signaling using intracellular calcium source 1/998 22/18722 0.700561908447773 0.842772747466779 BCAP31 1 GO:0042749 regulation of circadian sleep/wake cycle 1/998 22/18722 0.700561908447773 0.842772747466779 ADRB1 1 GO:0045663 positive regulation of myoblast differentiation 1/998 22/18722 0.700561908447773 0.842772747466779 MAPK14 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/998 22/18722 0.700561908447773 0.842772747466779 SORBS1 1 GO:0048026 positive regulation of mRNA splicing, via spliceosome 1/998 22/18722 0.700561908447773 0.842772747466779 TRA2B 1 GO:0051220 cytoplasmic sequestering of protein 1/998 22/18722 0.700561908447773 0.842772747466779 GOPC 1 GO:0055093 response to hyperoxia 1/998 22/18722 0.700561908447773 0.842772747466779 HDAC2 1 GO:0071467 cellular response to pH 1/998 22/18722 0.700561908447773 0.842772747466779 SLC9A1 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/998 22/18722 0.700561908447773 0.842772747466779 ANK3 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/998 22/18722 0.700561908447773 0.842772747466779 PARP1 1 GO:0009743 response to carbohydrate 12/998 253/18722 0.702252148089313 0.844611487024719 COLEC12/SERPINF1/GJA1/LRP5/IGF1R/LRP1/CTSV/CCDC186/TRA2B/TCF7L2/SLC29A1/KRT18 12 GO:0002698 negative regulation of immune effector process 5/998 110/18722 0.704192970132275 0.846555721174443 CD46/CD55/CD47/PRKDC/CD59 5 GO:0018958 phenol-containing compound metabolic process 5/998 110/18722 0.704192970132275 0.846555721174443 OPN3/SLC16A2/GCNT4/GATA3/BCL2 5 GO:0002683 negative regulation of immune system process 21/998 434/18722 0.708337947117057 0.851342638558508 FBN1/CD46/DPP4/DLG5/DLG1/CDK6/CD55/CD47/PRKDC/GLI3/TLR3/PAWR/YES1/EZR/CD59/MIA3/PPARG/MAPK14/CTNNB1/PLK2/HSPA9 21 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 3/998 68/18722 0.709916248601721 0.851791665234202 IL6ST/ISL1/HDAC2 3 GO:0046637 regulation of alpha-beta T cell differentiation 3/998 68/18722 0.709916248601721 0.851791665234202 GLI3/GATA3/PNP 3 GO:0046686 response to cadmium ion 3/998 68/18722 0.709916248601721 0.851791665234202 EGFR/CYB5A/ALAD 3 GO:0061912 selective autophagy 3/998 68/18722 0.709916248601721 0.851791665234202 HUWE1/UFL1/LGALS8 3 GO:1900046 regulation of hemostasis 3/998 68/18722 0.709916248601721 0.851791665234202 ANO6/NFE2L2/ANXA2 3 GO:0001974 blood vessel remodeling 2/998 46/18722 0.711468313071204 0.851791665234202 TGM2/MDM2 2 GO:0006195 purine nucleotide catabolic process 2/998 46/18722 0.711468313071204 0.851791665234202 NUDT4/PNP 2 GO:0031018 endocrine pancreas development 2/998 46/18722 0.711468313071204 0.851791665234202 CDK6/GSK3B 2 GO:0034198 cellular response to amino acid starvation 2/998 46/18722 0.711468313071204 0.851791665234202 EIF2AK4/SLC38A2 2 GO:0035094 response to nicotine 2/998 46/18722 0.711468313071204 0.851791665234202 BCL2/HDAC2 2 GO:0046839 phospholipid dephosphorylation 2/998 46/18722 0.711468313071204 0.851791665234202 PLPP3/SGPP1 2 GO:0051924 regulation of calcium ion transport 12/998 255/18722 0.712305059175478 0.851791665234202 ATP2B1/AHNAK/GJA1/CAMK2G/DMD/SLC9A1/TSPAN13/HOMER1/FMR1/P2RX4/CTNNB1/BCL2 12 GO:0007338 single fertilization 7/998 153/18722 0.713259823822616 0.851791665234202 CD46/SPESP1/HEXB/ASH1L/FOLR1/B4GALT1/KDM5B 7 GO:0071331 cellular response to hexose stimulus 7/998 153/18722 0.713259823822616 0.851791665234202 SERPINF1/LRP5/IGF1R/LRP1/CCDC186/TRA2B/SLC29A1 7 GO:0044282 small molecule catabolic process 18/998 376/18722 0.714889788653594 0.851791665234202 GLDC/SLC27A2/LRP5/FUT8/ATP2B4/HADHA/QPRT/CROT/ECHDC2/ACADVL/ECI2/CDO1/CPT2/ADH5/ECHDC1/ETFA/PNP/GLB1 18 GO:0001759 organ induction 1/998 23/18722 0.716542615152004 0.851791665234202 CTNNB1 1 GO:0002082 regulation of oxidative phosphorylation 1/998 23/18722 0.716542615152004 0.851791665234202 VCP 1 GO:0006541 glutamine metabolic process 1/998 23/18722 0.716542615152004 0.851791665234202 GFPT1 1 GO:0007130 synaptonemal complex assembly 1/998 23/18722 0.716542615152004 0.851791665234202 RAD21 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/998 23/18722 0.716542615152004 0.851791665234202 PNP 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/998 23/18722 0.716542615152004 0.851791665234202 LRP1 1 GO:0016578 histone deubiquitination 1/998 23/18722 0.716542615152004 0.851791665234202 USP22 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/998 23/18722 0.716542615152004 0.851791665234202 PABPN1 1 GO:0021895 cerebral cortex neuron differentiation 1/998 23/18722 0.716542615152004 0.851791665234202 OPHN1 1 GO:0031280 negative regulation of cyclase activity 1/998 23/18722 0.716542615152004 0.851791665234202 AKAP9 1 GO:0031338 regulation of vesicle fusion 1/998 23/18722 0.716542615152004 0.851791665234202 ANXA2 1 GO:0034695 response to prostaglandin E 1/998 23/18722 0.716542615152004 0.851791665234202 TGFBR3 1 GO:0035640 exploration behavior 1/998 23/18722 0.716542615152004 0.851791665234202 DPP4 1 GO:0035812 renal sodium excretion 1/998 23/18722 0.716542615152004 0.851791665234202 ATP6V1B1 1 GO:0040019 positive regulation of embryonic development 1/998 23/18722 0.716542615152004 0.851791665234202 AMOT 1 GO:0042438 melanin biosynthetic process 1/998 23/18722 0.716542615152004 0.851791665234202 OPN3 1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1/998 23/18722 0.716542615152004 0.851791665234202 NEDD4 1 GO:0043931 ossification involved in bone maturation 1/998 23/18722 0.716542615152004 0.851791665234202 PLXNB1 1 GO:0045662 negative regulation of myoblast differentiation 1/998 23/18722 0.716542615152004 0.851791665234202 MBNL3 1 GO:0045724 positive regulation of cilium assembly 1/998 23/18722 0.716542615152004 0.851791665234202 ATMIN 1 GO:0045980 negative regulation of nucleotide metabolic process 1/998 23/18722 0.716542615152004 0.851791665234202 PARP1 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/998 23/18722 0.716542615152004 0.851791665234202 CHPF 1 GO:0050765 negative regulation of phagocytosis 1/998 23/18722 0.716542615152004 0.851791665234202 CD47 1 GO:0051349 positive regulation of lyase activity 1/998 23/18722 0.716542615152004 0.851791665234202 NF1 1 GO:0051590 positive regulation of neurotransmitter transport 1/998 23/18722 0.716542615152004 0.851791665234202 ITGB1 1 GO:0051904 pigment granule transport 1/998 23/18722 0.716542615152004 0.851791665234202 MYO7A 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/998 23/18722 0.716542615152004 0.851791665234202 MAPK14 1 GO:0060353 regulation of cell adhesion molecule production 1/998 23/18722 0.716542615152004 0.851791665234202 COLEC12 1 GO:0060487 lung epithelial cell differentiation 1/998 23/18722 0.716542615152004 0.851791665234202 YAP1 1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 1/998 23/18722 0.716542615152004 0.851791665234202 YY1 1 GO:0071514 genetic imprinting 1/998 23/18722 0.716542615152004 0.851791665234202 DNMT3A 1 GO:0099590 neurotransmitter receptor internalization 1/998 23/18722 0.716542615152004 0.851791665234202 OPHN1 1 GO:1903306 negative regulation of regulated secretory pathway 1/998 23/18722 0.716542615152004 0.851791665234202 FMR1 1 GO:0046328 regulation of JNK cascade 6/998 133/18722 0.71865279030188 0.853604092916561 EGFR/APP/IGF1R/TLR3/MARVELD3/PDCD4 6 GO:0046632 alpha-beta T cell differentiation 5/998 112/18722 0.71903633348981 0.853604092916561 CTSL/GLI3/GATA3/BCL2/PNP 5 GO:0003143 embryonic heart tube morphogenesis 3/998 69/18722 0.71921172280022 0.853604092916561 YAP1/FOLR1/AHI1 3 GO:0033344 cholesterol efflux 3/998 69/18722 0.71921172280022 0.853604092916561 LRP1/ABCA1/PPARG 3 GO:0050688 regulation of defense response to virus 3/998 69/18722 0.71921172280022 0.853604092916561 TRIM44/HSP90AA1/EIF2AK4 3 GO:0050810 regulation of steroid biosynthetic process 3/998 69/18722 0.71921172280022 0.853604092916561 LPCAT3/SF1/MBTPS1 3 GO:0060193 positive regulation of lipase activity 3/998 69/18722 0.71921172280022 0.853604092916561 EGFR/FGFR2/ARL1 3 GO:0071326 cellular response to monosaccharide stimulus 7/998 154/18722 0.719557318549531 0.853820172760704 SERPINF1/LRP5/IGF1R/LRP1/CCDC186/TRA2B/SLC29A1 7 GO:0045582 positive regulation of T cell differentiation 4/998 91/18722 0.721613659874836 0.855279134891437 CD46/GLI3/GATA3/PNP 4 GO:0051952 regulation of amine transport 4/998 91/18722 0.721613659874836 0.855279134891437 ITGB1/SLC43A2/ARL6IP5/SYT7 4 GO:0001774 microglial cell activation 2/998 47/18722 0.722588826662733 0.855279134891437 APP/TLR3 2 GO:0009261 ribonucleotide catabolic process 2/998 47/18722 0.722588826662733 0.855279134891437 NUDT4/PNP 2 GO:0019884 antigen processing and presentation of exogenous antigen 2/998 47/18722 0.722588826662733 0.855279134891437 CTSL/CTSV 2 GO:0032369 negative regulation of lipid transport 2/998 47/18722 0.722588826662733 0.855279134891437 ITGAV/PLA2R1 2 GO:0045601 regulation of endothelial cell differentiation 2/998 47/18722 0.722588826662733 0.855279134891437 S1PR2/CTNNB1 2 GO:0047496 vesicle transport along microtubule 2/998 47/18722 0.722588826662733 0.855279134891437 DYNC1H1/CLN3 2 GO:0090279 regulation of calcium ion import 2/998 47/18722 0.722588826662733 0.855279134891437 HOMER1/CTNNB1 2 GO:0097300 programmed necrotic cell death 2/998 47/18722 0.722588826662733 0.855279134891437 TLR3/TRPM7 2 GO:0120163 negative regulation of cold-induced thermogenesis 2/998 47/18722 0.722588826662733 0.855279134891437 LGR4/NRDC 2 GO:0090276 regulation of peptide hormone secretion 9/998 196/18722 0.723483202979987 0.856143654297034 EGFR/DPP4/GJA1/LRP5/LRP1/ISL1/SYT7/SLC16A1/TCF7L2 9 GO:0071347 cellular response to interleukin-1 5/998 113/18722 0.726256170213103 0.859211793010696 CD47/RPS6KA5/USP10/OTUD4/YY1 5 GO:0002697 regulation of immune effector process 16/998 339/18722 0.727611915092142 0.859211793010696 CD46/TFRC/CADM1/CD55/CD47/PRKDC/HSPD1/TLR3/ANKRD17/CD59/RIF1/DHX36/FZD5/DDX1/GATA3/SNX4 16 GO:0045123 cellular extravasation 3/998 70/18722 0.728274027494835 0.859211793010696 ITGB1/CD47/JAM3 3 GO:0035249 synaptic transmission, glutamatergic 4/998 92/18722 0.729534407804259 0.859211793010696 EGFR/CLN3/HOMER1/OPHN1 4 GO:0032102 negative regulation of response to external stimulus 20/998 420/18722 0.730935209580215 0.859211793010696 SEMA6A/SEMA6D/NRP1/DPP4/SERPINF1/GJA1/ASH1L/ISL1/LPCAT3/YES1/SEMA3F/PPARG/RYK/MAPK14/SEMA4B/GATA3/PLK2/PHLDB2/VPS35/ANXA2 20 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/998 24/18722 0.731671256794782 0.859211793010696 RPS21 1 GO:0001783 B cell apoptotic process 1/998 24/18722 0.731671256794782 0.859211793010696 SLC39A10 1 GO:0002021 response to dietary excess 1/998 24/18722 0.731671256794782 0.859211793010696 ADRB1 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/998 24/18722 0.731671256794782 0.859211793010696 GATA3 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/998 24/18722 0.731671256794782 0.859211793010696 HSPD1 1 GO:0010155 regulation of proton transport 1/998 24/18722 0.731671256794782 0.859211793010696 ACTN4 1 GO:0016048 detection of temperature stimulus 1/998 24/18722 0.731671256794782 0.859211793010696 NR2F6 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/998 24/18722 0.731671256794782 0.859211793010696 ZDHHC17 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/998 24/18722 0.731671256794782 0.859211793010696 ZDHHC17 1 GO:0021697 cerebellar cortex formation 1/998 24/18722 0.731671256794782 0.859211793010696 OPHN1 1 GO:0022410 circadian sleep/wake cycle process 1/998 24/18722 0.731671256794782 0.859211793010696 ADRB1 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/998 24/18722 0.731671256794782 0.859211793010696 VCP 1 GO:0031639 plasminogen activation 1/998 24/18722 0.731671256794782 0.859211793010696 DHCR24 1 GO:0032928 regulation of superoxide anion generation 1/998 24/18722 0.731671256794782 0.859211793010696 EGFR 1 GO:0038095 Fc-epsilon receptor signaling pathway 1/998 24/18722 0.731671256794782 0.859211793010696 VAV3 1 GO:0043302 positive regulation of leukocyte degranulation 1/998 24/18722 0.731671256794782 0.859211793010696 SNX4 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/998 24/18722 0.731671256794782 0.859211793010696 ZDHHC17 1 GO:0050855 regulation of B cell receptor signaling pathway 1/998 24/18722 0.731671256794782 0.859211793010696 SLC39A10 1 GO:0051156 glucose 6-phosphate metabolic process 1/998 24/18722 0.731671256794782 0.859211793010696 RPIA 1 GO:0051905 establishment of pigment granule localization 1/998 24/18722 0.731671256794782 0.859211793010696 MYO7A 1 GO:0070129 regulation of mitochondrial translation 1/998 24/18722 0.731671256794782 0.859211793010696 LRPPRC 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/998 24/18722 0.731671256794782 0.859211793010696 MAPK14 1 GO:0071676 negative regulation of mononuclear cell migration 1/998 24/18722 0.731671256794782 0.859211793010696 MIA3 1 GO:0072010 glomerular epithelium development 1/998 24/18722 0.731671256794782 0.859211793010696 CD24 1 GO:0098743 cell aggregation 1/998 24/18722 0.731671256794782 0.859211793010696 MAPK14 1 GO:0120255 olefinic compound biosynthetic process 1/998 24/18722 0.731671256794782 0.859211793010696 HSD17B1 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/998 24/18722 0.731671256794782 0.859211793010696 VCP 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/998 24/18722 0.731671256794782 0.859211793010696 SLC5A3 1 GO:2000310 regulation of NMDA receptor activity 1/998 24/18722 0.731671256794782 0.859211793010696 APP 1 GO:0002673 regulation of acute inflammatory response 2/998 48/18722 0.733345103142423 0.860016797732837 IL6ST/ASH1L 2 GO:0002686 negative regulation of leukocyte migration 2/998 48/18722 0.733345103142423 0.860016797732837 DPP4/MIA3 2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 2/998 48/18722 0.733345103142423 0.860016797732837 ATRX/BOD1L1 2 GO:0090199 regulation of release of cytochrome c from mitochondria 2/998 48/18722 0.733345103142423 0.860016797732837 PMAIP1/LMNA 2 GO:1902003 regulation of amyloid-beta formation 2/998 48/18722 0.733345103142423 0.860016797732837 EFNA1/RTN4 2 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2/998 48/18722 0.733345103142423 0.860016797732837 SMARCC1/USP14 2 GO:0071805 potassium ion transmembrane transport 10/998 219/18722 0.736385726506389 0.86338869932402 AKAP9/ITGB1/DLG1/ANO6/ANK3/KCNN4/SLC12A9/SLC9A1/NEDD4/SLC1A3 10 GO:0032722 positive regulation of chemokine production 3/998 71/18722 0.737105218897978 0.863790331906069 APP/LRP1/TLR3 3 GO:0032755 positive regulation of interleukin-6 production 4/998 93/18722 0.737285292003639 0.863790331906069 APP/HSPD1/ISL1/TLR3 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 4/998 93/18722 0.737285292003639 0.863790331906069 AHNAK/DMD/SLC9A1/FMR1 4 GO:1903305 regulation of regulated secretory pathway 6/998 136/18722 0.738303254188917 0.863790331906069 SYT7/TRPV6/FMR1/ATP2A2/GSK3B/SNX4 6 GO:0002237 response to molecule of bacterial origin 17/998 363/18722 0.743354813147781 0.863790331906069 GJA1/CD55/CD24/HSPD1/ABCA1/GNG12/MAPK14/FGFR2/FZD5/ADH5/ASS1/ATP2A2/PDCD4/PRPF8/ALAD/HDAC2/PABPN1 17 GO:0000959 mitochondrial RNA metabolic process 2/998 49/18722 0.743744331411995 0.863790331906069 LRPPRC/TFAM 2 GO:0007602 phototransduction 2/998 49/18722 0.743744331411995 0.863790331906069 OPN3/CDS1 2 GO:0008206 bile acid metabolic process 2/998 49/18722 0.743744331411995 0.863790331906069 SLC27A2/OSBPL9 2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2/998 49/18722 0.743744331411995 0.863790331906069 SKP2/CUL5 2 GO:0052372 modulation by symbiont of entry into host 2/998 49/18722 0.743744331411995 0.863790331906069 ITGAV/P4HB 2 GO:0070741 response to interleukin-6 2/998 49/18722 0.743744331411995 0.863790331906069 YAP1/IL6ST 2 GO:0086009 membrane repolarization 2/998 49/18722 0.743744331411995 0.863790331906069 AKAP9/GJA5 2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/998 49/18722 0.743744331411995 0.863790331906069 GSK3B/PMAIP1 2 GO:1990573 potassium ion import across plasma membrane 2/998 49/18722 0.743744331411995 0.863790331906069 DLG1/SLC12A9 2 GO:1990928 response to amino acid starvation 2/998 49/18722 0.743744331411995 0.863790331906069 EIF2AK4/SLC38A2 2 GO:0007586 digestion 6/998 137/18722 0.744631284566359 0.863790331906069 LIMA1/KCNN4/LPCAT3/EZR/SLC22A5/ACO1 6 GO:0002690 positive regulation of leukocyte chemotaxis 4/998 94/18722 0.744867184265771 0.863790331906069 ANO6/CALR/SWAP70/PTK2 4 GO:0032091 negative regulation of protein binding 4/998 94/18722 0.744867184265771 0.863790331906069 LRPAP1/GOLGA2/ATP2A2/GSK3B 4 GO:0002791 regulation of peptide secretion 9/998 200/18722 0.745001784336835 0.863790331906069 EGFR/DPP4/GJA1/LRP5/LRP1/ISL1/SYT7/SLC16A1/TCF7L2 9 GO:0002534 cytokine production involved in inflammatory response 3/998 72/18722 0.745707601483352 0.863790331906069 MAPK14/PDCD4/CHID1 3 GO:0042246 tissue regeneration 3/998 72/18722 0.745707601483352 0.863790331906069 DAG1/YAP1/KLF5 3 GO:0043903 regulation of biological process involved in symbiotic interaction 3/998 72/18722 0.745707601483352 0.863790331906069 ITGAV/DDB1/P4HB 3 GO:0050709 negative regulation of protein secretion 3/998 72/18722 0.745707601483352 0.863790331906069 FRMD4A/ERP29/RAB11FIP1 3 GO:1900015 regulation of cytokine production involved in inflammatory response 3/998 72/18722 0.745707601483352 0.863790331906069 MAPK14/PDCD4/CHID1 3 GO:1905818 regulation of chromosome separation 3/998 72/18722 0.745707601483352 0.863790331906069 TPR/RAD21/ANAPC5 3 GO:0000244 spliceosomal tri-snRNP complex assembly 1/998 25/18722 0.745993220947034 0.863790331906069 PRPF8 1 GO:0006312 mitotic recombination 1/998 25/18722 0.745993220947034 0.863790331906069 RAD50 1 GO:0007274 neuromuscular synaptic transmission 1/998 25/18722 0.745993220947034 0.863790331906069 ERC1 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/998 25/18722 0.745993220947034 0.863790331906069 AK3 1 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1/998 25/18722 0.745993220947034 0.863790331906069 CD55 1 GO:0032104 regulation of response to extracellular stimulus 1/998 25/18722 0.745993220947034 0.863790331906069 TRIM24 1 GO:0032107 regulation of response to nutrient levels 1/998 25/18722 0.745993220947034 0.863790331906069 TRIM24 1 GO:0032753 positive regulation of interleukin-4 production 1/998 25/18722 0.745993220947034 0.863790331906069 GATA3 1 GO:0033119 negative regulation of RNA splicing 1/998 25/18722 0.745993220947034 0.863790331906069 SRSF4 1 GO:0033233 regulation of protein sumoylation 1/998 25/18722 0.745993220947034 0.863790331906069 CTNNB1 1 GO:0042730 fibrinolysis 1/998 25/18722 0.745993220947034 0.863790331906069 ANXA2 1 GO:0044550 secondary metabolite biosynthetic process 1/998 25/18722 0.745993220947034 0.863790331906069 OPN3 1 GO:0045324 late endosome to vacuole transport 1/998 25/18722 0.745993220947034 0.863790331906069 LEPROT 1 GO:0045822 negative regulation of heart contraction 1/998 25/18722 0.745993220947034 0.863790331906069 ATP2A2 1 GO:0046039 GTP metabolic process 1/998 25/18722 0.745993220947034 0.863790331906069 AK3 1 GO:0046835 carbohydrate phosphorylation 1/998 25/18722 0.745993220947034 0.863790331906069 GNPTAB 1 GO:0050951 sensory perception of temperature stimulus 1/998 25/18722 0.745993220947034 0.863790331906069 NR2F6 1 GO:0051204 protein insertion into mitochondrial membrane 1/998 25/18722 0.745993220947034 0.863790331906069 HSP90AA1 1 GO:0051307 meiotic chromosome separation 1/998 25/18722 0.745993220947034 0.863790331906069 TOP2B 1 GO:0060074 synapse maturation 1/998 25/18722 0.745993220947034 0.863790331906069 CLSTN1 1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 1/998 25/18722 0.745993220947034 0.863790331906069 DHX36 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/998 25/18722 0.745993220947034 0.863790331906069 NR2F6 1 GO:0070199 establishment of protein localization to chromosome 1/998 25/18722 0.745993220947034 0.863790331906069 NIPBL 1 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 1/998 25/18722 0.745993220947034 0.863790331906069 HSPA1B 1 GO:0072012 glomerulus vasculature development 1/998 25/18722 0.745993220947034 0.863790331906069 BMP7 1 GO:0090312 positive regulation of protein deacetylation 1/998 25/18722 0.745993220947034 0.863790331906069 NIPBL 1 GO:0090330 regulation of platelet aggregation 1/998 25/18722 0.745993220947034 0.863790331906069 IL6ST 1 GO:0099560 synaptic membrane adhesion 1/998 25/18722 0.745993220947034 0.863790331906069 MAPK14 1 GO:1902993 positive regulation of amyloid precursor protein catabolic process 1/998 25/18722 0.745993220947034 0.863790331906069 EFNA1 1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 1/998 25/18722 0.745993220947034 0.863790331906069 NFAT5 1 GO:1905563 negative regulation of vascular endothelial cell proliferation 1/998 25/18722 0.745993220947034 0.863790331906069 PPARG 1 GO:0002532 production of molecular mediator involved in inflammatory response 4/998 95/18722 0.752281117613267 0.870034724870092 MAPK14/PDCD4/SNX4/CHID1 4 GO:0045666 positive regulation of neuron differentiation 4/998 95/18722 0.752281117613267 0.870034724870092 BMP7/NRCAM/SPAG9/EIF4G1 4 GO:0015850 organic hydroxy compound transport 13/998 284/18722 0.752608155506176 0.870034724870092 SLC6A4/SLC5A3/LRP1/LIMA1/ABCA1/LPCAT3/SYT7/KDM5B/SLC16A1/OSBPL9/PPARG/TMF1/ANXA2 13 GO:0001961 positive regulation of cytokine-mediated signaling pathway 2/998 50/18722 0.753793969423139 0.870034724870092 TRIM44/HSPA1B 2 GO:0002639 positive regulation of immunoglobulin production 2/998 50/18722 0.753793969423139 0.870034724870092 TFRC/RIF1 2 GO:0007080 mitotic metaphase plate congression 2/998 50/18722 0.753793969423139 0.870034724870092 EML4/HNRNPU 2 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/998 50/18722 0.753793969423139 0.870034724870092 PPP1R10/NFE2L2 2 GO:0043628 ncRNA 3'-end processing 2/998 50/18722 0.753793969423139 0.870034724870092 INTS6/RPS21 2 GO:0046638 positive regulation of alpha-beta T cell differentiation 2/998 50/18722 0.753793969423139 0.870034724870092 GLI3/PNP 2 GO:0051646 mitochondrion localization 2/998 50/18722 0.753793969423139 0.870034724870092 LRPPRC/ARMCX3 2 GO:1902930 regulation of alcohol biosynthetic process 2/998 50/18722 0.753793969423139 0.870034724870092 LPCAT3/MBTPS1 2 GO:0072676 lymphocyte migration 5/998 117/18722 0.753794069235871 0.870034724870092 APP/DOCK8/MIA3/GATA3/PLEC 5 GO:0002637 regulation of immunoglobulin production 3/998 73/18722 0.754083706153764 0.870034724870092 TFRC/PRKDC/RIF1 3 GO:0009166 nucleotide catabolic process 3/998 73/18722 0.754083706153764 0.870034724870092 NUDT4/VCP/PNP 3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 3/998 73/18722 0.754083706153764 0.870034724870092 LRP5/LRP1/CCDC186 3 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 3/998 73/18722 0.754083706153764 0.870034724870092 EGFR/IFI6/ERRFI1 3 GO:0006310 DNA recombination 14/998 305/18722 0.754995931615825 0.870034724870092 TFRC/PARP1/FUS/PRKDC/HSPD1/RAD50/SFPQ/SETD2/SWAP70/TOP2B/RAD21/RIF1/NIPBL/YY1 14 GO:0090087 regulation of peptide transport 9/998 202/18722 0.755320409278289 0.870034724870092 EGFR/DPP4/GJA1/LRP5/LRP1/ISL1/SYT7/SLC16A1/TCF7L2 9 GO:0048285 organelle fission 23/998 488/18722 0.759086228876406 0.870034724870092 BMP7/LRP5/EML4/CALR/RAD50/OBSL1/ATRX/TPR/REEP3/TOP2B/PPARG/RAD21/SUN1/EPS8/ANAPC5/GOLGA2/PDS5A/HSPA1B/INF2/NIPBL/STAG1/VPS35/HNRNPU 23 GO:0002764 immune response-regulating signaling pathway 22/998 468/18722 0.759306495947507 0.870034724870092 COLEC12/LGR4/SLC39A10/CD24/CD47/KCNN4/VAV3/HSPD1/TLR3/PUM1/PAWR/YES1/RTN4/EZR/ANKRD17/PLEKHA1/PTK2/GATA3/BCL2/HSPA1B/SPPL3/OTUD4 22 GO:0051304 chromosome separation 4/998 96/18722 0.759528275921366 0.870034724870092 TPR/TOP2B/RAD21/ANAPC5 4 GO:0001963 synaptic transmission, dopaminergic 1/998 26/18722 0.759551479785075 0.870034724870092 SLC6A4 1 GO:0002418 immune response to tumor cell 1/998 26/18722 0.759551479785075 0.870034724870092 HSPD1 1 GO:0003416 endochondral bone growth 1/998 26/18722 0.759551479785075 0.870034724870092 FGFR2 1 GO:0006706 steroid catabolic process 1/998 26/18722 0.759551479785075 0.870034724870092 STS 1 GO:0009164 nucleoside catabolic process 1/998 26/18722 0.759551479785075 0.870034724870092 PNP 1 GO:0009435 NAD biosynthetic process 1/998 26/18722 0.759551479785075 0.870034724870092 QPRT 1 GO:0014829 vascular associated smooth muscle contraction 1/998 26/18722 0.759551479785075 0.870034724870092 ATP2B1 1 GO:0016226 iron-sulfur cluster assembly 1/998 26/18722 0.759551479785075 0.870034724870092 HSPA9 1 GO:0021952 central nervous system projection neuron axonogenesis 1/998 26/18722 0.759551479785075 0.870034724870092 MYCBP2 1 GO:0031163 metallo-sulfur cluster assembly 1/998 26/18722 0.759551479785075 0.870034724870092 HSPA9 1 GO:0032682 negative regulation of chemokine production 1/998 26/18722 0.759551479785075 0.870034724870092 SUZ12 1 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 1/998 26/18722 0.759551479785075 0.870034724870092 HSPA1B 1 GO:0042278 purine nucleoside metabolic process 1/998 26/18722 0.759551479785075 0.870034724870092 PNP 1 GO:0043094 cellular metabolic compound salvage 1/998 26/18722 0.759551479785075 0.870034724870092 PNP 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/998 26/18722 0.759551479785075 0.870034724870092 CADM1 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/998 26/18722 0.759551479785075 0.870034724870092 GLI3 1 GO:0046755 viral budding 1/998 26/18722 0.759551479785075 0.870034724870092 NEDD4 1 GO:0051350 negative regulation of lyase activity 1/998 26/18722 0.759551479785075 0.870034724870092 AKAP9 1 GO:0051875 pigment granule localization 1/998 26/18722 0.759551479785075 0.870034724870092 MYO7A 1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 1/998 26/18722 0.759551479785075 0.870034724870092 DMD 1 GO:0060352 cell adhesion molecule production 1/998 26/18722 0.759551479785075 0.870034724870092 COLEC12 1 GO:0070193 synaptonemal complex organization 1/998 26/18722 0.759551479785075 0.870034724870092 RAD21 1 GO:0070977 bone maturation 1/998 26/18722 0.759551479785075 0.870034724870092 PLXNB1 1 GO:0071425 hematopoietic stem cell proliferation 1/998 26/18722 0.759551479785075 0.870034724870092 N4BP2L2 1 GO:1901071 glucosamine-containing compound metabolic process 1/998 26/18722 0.759551479785075 0.870034724870092 EXTL2 1 GO:1902186 regulation of viral release from host cell 1/998 26/18722 0.759551479785075 0.870034724870092 DDB1 1 GO:1903523 negative regulation of blood circulation 1/998 26/18722 0.759551479785075 0.870034724870092 ATP2A2 1 GO:2000108 positive regulation of leukocyte apoptotic process 1/998 26/18722 0.759551479785075 0.870034724870092 PIK3CB 1 GO:0071346 cellular response to interferon-gamma 5/998 118/18722 0.760345285033587 0.870752957481983 CD47/TLR3/PPARG/MYO1C/ASS1 5 GO:0010822 positive regulation of mitochondrion organization 3/998 74/18722 0.762236269471479 0.872535751569961 GSK3B/PMAIP1/VPS35 3 GO:1901568 fatty acid derivative metabolic process 3/998 74/18722 0.762236269471479 0.872535751569961 ACSL3/FAR1/TECR 3 GO:0046165 alcohol biosynthetic process 6/998 140/18722 0.762951265902471 0.873162770556072 ISYNA1/LPCAT3/MBTPS1/DHCR24/SPTLC3/FDFT1 6 GO:0050982 detection of mechanical stimulus 2/998 51/18722 0.763501695139534 0.873218477617416 CTNNB1/PTK2 2 GO:0051339 regulation of lyase activity 2/998 51/18722 0.763501695139534 0.873218477617416 AKAP9/NF1 2 GO:1903307 positive regulation of regulated secretory pathway 2/998 51/18722 0.763501695139534 0.873218477617416 SYT7/SNX4 2 GO:0051100 negative regulation of binding 7/998 162/18722 0.766529971547815 0.876489921474188 LRPAP1/MSX2/WAPL/GOLGA2/ATP2A2/GSK3B/HDAC2 7 GO:0071216 cellular response to biotic stimulus 11/998 246/18722 0.766769964760397 0.876572363918115 HSPA5/CD55/CCDC47/ABCA1/MAPK14/FZD5/ASS1/PDCD4/GSK3B/PRPF8/PABPN1 11 GO:1903038 negative regulation of leukocyte cell-cell adhesion 6/998 141/18722 0.768837646622434 0.878743728768767 DLG5/DLG1/GLI3/PAWR/MIA3/ASS1 6 GO:0000469 cleavage involved in rRNA processing 1/998 27/18722 0.772386718508572 0.878933187705875 RPS21 1 GO:0000737 DNA catabolic process, endonucleolytic 1/998 27/18722 0.772386718508572 0.878933187705875 DICER1 1 GO:0001958 endochondral ossification 1/998 27/18722 0.772386718508572 0.878933187705875 MMP14 1 GO:0007026 negative regulation of microtubule depolymerization 1/998 27/18722 0.772386718508572 0.878933187705875 CAMSAP2 1 GO:0007628 adult walking behavior 1/998 27/18722 0.772386718508572 0.878933187705875 OXR1 1 GO:0010758 regulation of macrophage chemotaxis 1/998 27/18722 0.772386718508572 0.878933187705875 PTK2 1 GO:0014850 response to muscle activity 1/998 27/18722 0.772386718508572 0.878933187705875 TOMM20 1 GO:0031954 positive regulation of protein autophosphorylation 1/998 27/18722 0.772386718508572 0.878933187705875 RAD50 1 GO:0032781 positive regulation of ATPase activity 1/998 27/18722 0.772386718508572 0.878933187705875 TOR1AIP2 1 GO:0034505 tooth mineralization 1/998 27/18722 0.772386718508572 0.878933187705875 TFAP2A 1 GO:0036037 CD8-positive, alpha-beta T cell activation 1/998 27/18722 0.772386718508572 0.878933187705875 BCL2 1 GO:0036075 replacement ossification 1/998 27/18722 0.772386718508572 0.878933187705875 MMP14 1 GO:0042104 positive regulation of activated T cell proliferation 1/998 27/18722 0.772386718508572 0.878933187705875 CD24 1 GO:0042745 circadian sleep/wake cycle 1/998 27/18722 0.772386718508572 0.878933187705875 ADRB1 1 GO:0045606 positive regulation of epidermal cell differentiation 1/998 27/18722 0.772386718508572 0.878933187705875 NCOA3 1 GO:0046337 phosphatidylethanolamine metabolic process 1/998 27/18722 0.772386718508572 0.878933187705875 PISD 1 GO:0060142 regulation of syncytium formation by plasma membrane fusion 1/998 27/18722 0.772386718508572 0.878933187705875 MAPK14 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/998 27/18722 0.772386718508572 0.878933187705875 PPARG 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/998 27/18722 0.772386718508572 0.878933187705875 AKAP9 1 GO:1903859 regulation of dendrite extension 1/998 27/18722 0.772386718508572 0.878933187705875 SPAG9 1 GO:0007129 homologous chromosome pairing at meiosis 2/998 52/18722 0.772875361953203 0.878933187705875 RAD21/SUN1 2 GO:0043392 negative regulation of DNA binding 2/998 52/18722 0.772875361953203 0.878933187705875 MSX2/HDAC2 2 GO:0072523 purine-containing compound catabolic process 2/998 52/18722 0.772875361953203 0.878933187705875 NUDT4/PNP 2 GO:0032642 regulation of chemokine production 4/998 98/18722 0.773527697102852 0.879483472685973 APP/LRP1/TLR3/SUZ12 4 GO:0009123 nucleoside monophosphate metabolic process 3/998 76/18722 0.777882629240468 0.884242370403764 DLG1/AK3/PNP 3 GO:0034763 negative regulation of transmembrane transport 6/998 143/18722 0.780282744735195 0.886006417215624 SLC43A2/ANK3/ARL6IP5/FMR1/NEDD4/GOPC 6 GO:0062013 positive regulation of small molecule metabolic process 6/998 143/18722 0.780282744735195 0.886006417215624 APP/DDB1/SORBS1/PPARG/VCP/PMAIP1 6 GO:0002444 myeloid leukocyte mediated immunity 4/998 99/18722 0.780282992981697 0.886006417215624 DHX36/DDX1/SNX4/ANXA3 4 GO:0015837 amine transport 4/998 99/18722 0.780282992981697 0.886006417215624 ITGB1/SLC43A2/ARL6IP5/SYT7 4 GO:0032602 chemokine production 4/998 99/18722 0.780282992981697 0.886006417215624 APP/LRP1/TLR3/SUZ12 4 GO:0002707 negative regulation of lymphocyte mediated immunity 2/998 53/18722 0.781922958220434 0.886904141835517 CD46/CD55 2 GO:0033059 cellular pigmentation 2/998 53/18722 0.781922958220434 0.886904141835517 MYO7A/BCL2 2 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/998 53/18722 0.781922958220434 0.886904141835517 MET/ATP2B4 2 GO:0050819 negative regulation of coagulation 2/998 53/18722 0.781922958220434 0.886904141835517 ANXA5/ANXA2 2 GO:0071715 icosanoid transport 2/998 53/18722 0.781922958220434 0.886904141835517 PLA2R1/P2RX4 2 GO:0000423 mitophagy 1/998 28/18722 0.784537456937481 0.88736353177439 HUWE1 1 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1/998 28/18722 0.784537456937481 0.88736353177439 CALR 1 GO:0002675 positive regulation of acute inflammatory response 1/998 28/18722 0.784537456937481 0.88736353177439 IL6ST 1 GO:0008299 isoprenoid biosynthetic process 1/998 28/18722 0.784537456937481 0.88736353177439 ALDH1A3 1 GO:0009065 glutamine family amino acid catabolic process 1/998 28/18722 0.784537456937481 0.88736353177439 ATP2B4 1 GO:0010818 T cell chemotaxis 1/998 28/18722 0.784537456937481 0.88736353177439 PLEC 1 GO:0010884 positive regulation of lipid storage 1/998 28/18722 0.784537456937481 0.88736353177439 HILPDA 1 GO:0045589 regulation of regulatory T cell differentiation 1/998 28/18722 0.784537456937481 0.88736353177439 CD46 1 GO:0060259 regulation of feeding behavior 1/998 28/18722 0.784537456937481 0.88736353177439 EIF2AK4 1 GO:0062125 regulation of mitochondrial gene expression 1/998 28/18722 0.784537456937481 0.88736353177439 LRPPRC 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/998 28/18722 0.784537456937481 0.88736353177439 PMAIP1 1 GO:0090659 walking behavior 1/998 28/18722 0.784537456937481 0.88736353177439 OXR1 1 GO:1903672 positive regulation of sprouting angiogenesis 1/998 28/18722 0.784537456937481 0.88736353177439 TJP1 1 GO:0006367 transcription initiation from RNA polymerase II promoter 3/998 77/18722 0.785382754615958 0.887934898624927 ZNF451/DHX36/CDK7 3 GO:0032418 lysosome localization 3/998 77/18722 0.785382754615958 0.887934898624927 SPAG9/TMEM106B/SNX4 3 GO:0019218 regulation of steroid metabolic process 4/998 100/18722 0.786877561298747 0.889432290006659 LPCAT3/SF1/ACADVL/MBTPS1 4 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/998 54/18722 0.790652570605455 0.893119227851813 CD46/CD55 2 GO:0006968 cellular defense response 2/998 54/18722 0.790652570605455 0.893119227851813 ITGB1/LGALS3BP 2 GO:0010659 cardiac muscle cell apoptotic process 2/998 54/18722 0.790652570605455 0.893119227851813 PPP1R10/NFE2L2 2 GO:0050852 T cell receptor signaling pathway 5/998 123/18722 0.791137347228476 0.893265062184254 KCNN4/PAWR/EZR/GATA3/SPPL3 5 GO:0007269 neurotransmitter secretion 6/998 145/18722 0.791294945911162 0.893265062184254 PPP1R9A/SYT7/FMR1/ATP2A2/GSK3B/MCTP2 6 GO:0099643 signal release from synapse 6/998 145/18722 0.791294945911162 0.893265062184254 PPP1R9A/SYT7/FMR1/ATP2A2/GSK3B/MCTP2 6 GO:0061045 negative regulation of wound healing 3/998 78/18722 0.792671962011369 0.894626094609026 GJA1/PHLDB2/ANXA2 3 GO:0001773 myeloid dendritic cell activation 1/998 29/18722 0.796040164649923 0.895330827151497 ITGB8 1 GO:0003209 cardiac atrium morphogenesis 1/998 29/18722 0.796040164649923 0.895330827151497 ISL1 1 GO:0006734 NADH metabolic process 1/998 29/18722 0.796040164649923 0.895330827151497 VCP 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/998 29/18722 0.796040164649923 0.895330827151497 AK3 1 GO:0010390 histone monoubiquitination 1/998 29/18722 0.796040164649923 0.895330827151497 DDB1 1 GO:0010458 exit from mitosis 1/998 29/18722 0.796040164649923 0.895330827151497 EPS8 1 GO:0019359 nicotinamide nucleotide biosynthetic process 1/998 29/18722 0.796040164649923 0.895330827151497 QPRT 1 GO:0019363 pyridine nucleotide biosynthetic process 1/998 29/18722 0.796040164649923 0.895330827151497 QPRT 1 GO:0042759 long-chain fatty acid biosynthetic process 1/998 29/18722 0.796040164649923 0.895330827151497 QKI 1 GO:0043153 entrainment of circadian clock by photoperiod 1/998 29/18722 0.796040164649923 0.895330827151497 NR2F6 1 GO:0048679 regulation of axon regeneration 1/998 29/18722 0.796040164649923 0.895330827151497 LRP1 1 GO:0048753 pigment granule organization 1/998 29/18722 0.796040164649923 0.895330827151497 BCL2 1 GO:0090025 regulation of monocyte chemotaxis 1/998 29/18722 0.796040164649923 0.895330827151497 ANO6 1 GO:0098868 bone growth 1/998 29/18722 0.796040164649923 0.895330827151497 FGFR2 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/998 29/18722 0.796040164649923 0.895330827151497 ANK3 1 GO:1902430 negative regulation of amyloid-beta formation 1/998 29/18722 0.796040164649923 0.895330827151497 RTN4 1 GO:0000280 nuclear division 20/998 439/18722 0.796772239814214 0.895614208898318 BMP7/LRP5/EML4/CALR/RAD50/OBSL1/ATRX/TPR/REEP3/TOP2B/RAD21/SUN1/EPS8/ANAPC5/GOLGA2/PDS5A/HSPA1B/NIPBL/STAG1/HNRNPU 20 GO:0001818 negative regulation of cytokine production 16/998 357/18722 0.796797839516036 0.895614208898318 ATP2B1/LGR4/CD24/RNF128/RPS6KA5/CD2AP/EZR/DICER1/SUZ12/ERRFI1/GATA3/PDCD4/OTUD7B/CHID1/TIA1/YY1 16 GO:0034612 response to tumor necrosis factor 11/998 253/18722 0.796806742067169 0.895614208898318 SPPL2A/ACTN4/MAPK14/SPPL2B/GATA3/ASS1/OCLN/HSPA1B/PRPF8/NFE2L2/KRT18 11 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/998 168/18722 0.797809044166257 0.896547787256141 CD46/TFRC/CD55/HSPD1/RIF1/FZD5/GATA3 7 GO:0006414 translational elongation 2/998 55/18722 0.799072350941574 0.897774207933282 NEMF/SECISBP2 2 GO:0062014 negative regulation of small molecule metabolic process 4/998 102/18722 0.799591784655963 0.89797132882099 PARP1/ATP2B4/ACADVL/FAM3C 4 GO:1904063 negative regulation of cation transmembrane transport 4/998 102/18722 0.799591784655963 0.89797132882099 SLC43A2/ANK3/FMR1/NEDD4 4 GO:1903531 negative regulation of secretion by cell 6/998 147/18722 0.801879912097797 0.900347316357548 GJA1/FRMD4A/PPP1R9A/ERP29/FMR1/RAB11FIP1 6 GO:0009152 purine ribonucleotide biosynthetic process 7/998 169/18722 0.802699188549906 0.901073417204699 SLC26A2/ACSS1/PARP1/VCP/ACSL3/AK3/TECR 7 GO:0019233 sensory perception of pain 4/998 103/18722 0.805715304446764 0.902038354112855 MME/SLC9A1/P2RX4/NR2F6 4 GO:1905037 autophagosome organization 4/998 103/18722 0.805715304446764 0.902038354112855 CLN3/GABARAPL1/TMEM41B/ATP2A2 4 GO:0007202 activation of phospholipase C activity 1/998 30/18722 0.806929370003765 0.902038354112855 EGFR 1 GO:0008209 androgen metabolic process 1/998 30/18722 0.806929370003765 0.902038354112855 PLEKHA1 1 GO:0009264 deoxyribonucleotide catabolic process 1/998 30/18722 0.806929370003765 0.902038354112855 PNP 1 GO:0010669 epithelial structure maintenance 1/998 30/18722 0.806929370003765 0.902038354112855 SLC22A5 1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/998 30/18722 0.806929370003765 0.902038354112855 DMD 1 GO:0017145 stem cell division 1/998 30/18722 0.806929370003765 0.902038354112855 NCOA3 1 GO:0030204 chondroitin sulfate metabolic process 1/998 30/18722 0.806929370003765 0.902038354112855 CHPF 1 GO:0032480 negative regulation of type I interferon production 1/998 30/18722 0.806929370003765 0.902038354112855 YY1 1 GO:0036296 response to increased oxygen levels 1/998 30/18722 0.806929370003765 0.902038354112855 HDAC2 1 GO:0043032 positive regulation of macrophage activation 1/998 30/18722 0.806929370003765 0.902038354112855 HSPD1 1 GO:0043304 regulation of mast cell degranulation 1/998 30/18722 0.806929370003765 0.902038354112855 SNX4 1 GO:0045577 regulation of B cell differentiation 1/998 30/18722 0.806929370003765 0.902038354112855 MMP14 1 GO:0045948 positive regulation of translational initiation 1/998 30/18722 0.806929370003765 0.902038354112855 EIF2AK4 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/998 30/18722 0.806929370003765 0.902038354112855 EGFR 1 GO:0070168 negative regulation of biomineral tissue development 1/998 30/18722 0.806929370003765 0.902038354112855 LTBP3 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/998 30/18722 0.806929370003765 0.902038354112855 HSP90AA1 1 GO:1903579 negative regulation of ATP metabolic process 1/998 30/18722 0.806929370003765 0.902038354112855 PARP1 1 GO:0002181 cytoplasmic translation 6/998 148/18722 0.807014202654884 0.902038354112855 EIF3A/EIF4G1/FMR1/DHX36/DENR/RPS21 6 GO:0032874 positive regulation of stress-activated MAPK cascade 5/998 126/18722 0.808077494312652 0.903033518366086 APP/ARL6IP5/MAP3K4/TLR3/EMC10 5 GO:0046634 regulation of alpha-beta T cell activation 4/998 104/18722 0.81168581024204 0.906871734490411 CD55/GLI3/GATA3/PNP 4 GO:0000422 autophagy of mitochondrion 3/998 81/18722 0.813309461113288 0.907057475029018 HUWE1/GABARAPL1/FZD5 3 GO:0061726 mitochondrion disassembly 3/998 81/18722 0.813309461113288 0.907057475029018 HUWE1/GABARAPL1/FZD5 3 GO:2000243 positive regulation of reproductive process 3/998 81/18722 0.813309461113288 0.907057475029018 CTNNB1/AGO2/HDAC2 3 GO:0006754 ATP biosynthetic process 2/998 57/18722 0.81501517229161 0.907057475029018 PARP1/VCP 2 GO:0051289 protein homotetramerization 2/998 57/18722 0.81501517229161 0.907057475029018 GOLGA2/ALDH1A3 2 GO:0051785 positive regulation of nuclear division 2/998 57/18722 0.81501517229161 0.907057475029018 LRP5/ANAPC5 2 GO:0060760 positive regulation of response to cytokine stimulus 2/998 57/18722 0.81501517229161 0.907057475029018 TRIM44/HSPA1B 2 GO:0061756 leukocyte adhesion to vascular endothelial cell 2/998 57/18722 0.81501517229161 0.907057475029018 NFAT5/ITGB1 2 GO:0042593 glucose homeostasis 11/998 258/18722 0.816473077318678 0.907057475029018 SERPINF1/LRP5/IGF1R/FAM3B/LRP1/CCDC186/SLC16A1/PPARG/TRA2B/TCF7L2/SLC29A1 11 GO:0001678 cellular glucose homeostasis 7/998 172/18722 0.816827384148765 0.907057475029018 SERPINF1/LRP5/IGF1R/LRP1/CCDC186/TRA2B/SLC29A1 7 GO:0001782 B cell homeostasis 1/998 31/18722 0.8172377633665 0.907057475029018 BCL2 1 GO:0002063 chondrocyte development 1/998 31/18722 0.8172377633665 0.907057475029018 SERPINH1 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/998 31/18722 0.8172377633665 0.907057475029018 CADM1 1 GO:0002828 regulation of type 2 immune response 1/998 31/18722 0.8172377633665 0.907057475029018 GATA3 1 GO:0018200 peptidyl-glutamic acid modification 1/998 31/18722 0.8172377633665 0.907057475029018 PARP1 1 GO:0031063 regulation of histone deacetylation 1/998 31/18722 0.8172377633665 0.907057475029018 NIPBL 1 GO:0031114 regulation of microtubule depolymerization 1/998 31/18722 0.8172377633665 0.907057475029018 CAMSAP2 1 GO:0033006 regulation of mast cell activation involved in immune response 1/998 31/18722 0.8172377633665 0.907057475029018 SNX4 1 GO:0034472 snRNA 3'-end processing 1/998 31/18722 0.8172377633665 0.907057475029018 INTS6 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/998 31/18722 0.8172377633665 0.907057475029018 PNP 1 GO:0045066 regulatory T cell differentiation 1/998 31/18722 0.8172377633665 0.907057475029018 CD46 1 GO:0046386 deoxyribose phosphate catabolic process 1/998 31/18722 0.8172377633665 0.907057475029018 PNP 1 GO:0048710 regulation of astrocyte differentiation 1/998 31/18722 0.8172377633665 0.907057475029018 IL6ST 1 GO:0050482 arachidonic acid secretion 1/998 31/18722 0.8172377633665 0.907057475029018 PLA2R1 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/998 31/18722 0.8172377633665 0.907057475029018 CTNNB1 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/998 31/18722 0.8172377633665 0.907057475029018 ERRFI1 1 GO:0110150 negative regulation of biomineralization 1/998 31/18722 0.8172377633665 0.907057475029018 LTBP3 1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/998 31/18722 0.8172377633665 0.907057475029018 GSK3B 1 GO:1903963 arachidonate transport 1/998 31/18722 0.8172377633665 0.907057475029018 PLA2R1 1 GO:1905144 response to acetylcholine 1/998 31/18722 0.8172377633665 0.907057475029018 ATP2B4 1 GO:1905145 cellular response to acetylcholine 1/998 31/18722 0.8172377633665 0.907057475029018 ATP2B4 1 GO:0016079 synaptic vesicle exocytosis 4/998 105/18722 0.817505429172586 0.907161710034021 SYT7/FMR1/ATP2A2/GSK3B 4 GO:0032612 interleukin-1 production 5/998 128/18722 0.818751443290858 0.907960957871712 APP/ISL1/ERRFI1/FZD5/HDAC2 5 GO:0032652 regulation of interleukin-1 production 5/998 128/18722 0.818751443290858 0.907960957871712 APP/ISL1/ERRFI1/FZD5/HDAC2 5 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 5/998 128/18722 0.818751443290858 0.907960957871712 APP/ARL6IP5/MAP3K4/TLR3/EMC10 5 GO:0032496 response to lipopolysaccharide 15/998 343/18722 0.819528629888981 0.907960957871712 GJA1/CD55/HSPD1/ABCA1/GNG12/MAPK14/FGFR2/ADH5/ASS1/ATP2A2/PDCD4/PRPF8/ALAD/HDAC2/PABPN1 15 GO:1903131 mononuclear cell differentiation 19/998 426/18722 0.819684615825781 0.907960957871712 CD46/CTSL/ITGB8/ITGB1/PBX1/CDK6/PRKDC/HECTD1/GLI3/PPARG/CTNNB1/FZD5/MMP14/GATA3/BCL2/FASN/YY1/PNP/KDELR1 19 GO:0007032 endosome organization 3/998 82/18722 0.819790836124737 0.907960957871712 EEA1/HOOK2/AKTIP 3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 3/998 82/18722 0.819790836124737 0.907960957871712 BCL2/GSK3B/PMAIP1 3 GO:0009205 purine ribonucleoside triphosphate metabolic process 3/998 82/18722 0.819790836124737 0.907960957871712 PARP1/VCP/AK3 3 GO:0072527 pyrimidine-containing compound metabolic process 3/998 82/18722 0.819790836124737 0.907960957871712 SLC19A3/TET2/AK3 3 GO:0033500 carbohydrate homeostasis 11/998 259/18722 0.820230262276918 0.908254973350539 SERPINF1/LRP5/IGF1R/FAM3B/LRP1/CCDC186/SLC16A1/PPARG/TRA2B/TCF7L2/SLC29A1 11 GO:0010574 regulation of vascular endothelial growth factor production 2/998 58/18722 0.822554588537618 0.910249577523294 IL6ST/ISL1 2 GO:0034340 response to type I interferon 2/998 58/18722 0.822554588537618 0.910249577523294 SETD2/PTPN1 2 GO:0042743 hydrogen peroxide metabolic process 2/998 58/18722 0.822554588537618 0.910249577523294 EGFR/PRDX4 2 GO:0001824 blastocyst development 4/998 106/18722 0.823176353050596 0.910551639677365 YAP1/N4BP2L2/RTN4/TGFBR1 4 GO:0019882 antigen processing and presentation 4/998 106/18722 0.823176353050596 0.910551639677365 CTSL/CALR/CTSV/RAB6A 4 GO:0070374 positive regulation of ERK1 and ERK2 cascade 9/998 217/18722 0.823411348231964 0.910618650523 EGFR/APP/NRP1/LRP1/GCNT2/FERMT2/TPBG/GAREM1/FGFR2 9 GO:0001510 RNA methylation 3/998 83/18722 0.826079621458908 0.912264452877311 ZC3H13/TARBP1/CMTR1 3 GO:0050672 negative regulation of lymphocyte proliferation 3/998 83/18722 0.826079621458908 0.912264452877311 DLG5/DLG1/PAWR 3 GO:0050871 positive regulation of B cell activation 6/998 152/18722 0.82651825993147 0.912264452877311 TFRC/SLC39A10/VAV3/RIF1/MMP14/BCL2 6 GO:0006308 DNA catabolic process 1/998 32/18722 0.826996294860815 0.912264452877311 DICER1 1 GO:0006506 GPI anchor biosynthetic process 1/998 32/18722 0.826996294860815 0.912264452877311 PGAP1 1 GO:0032196 transposition 1/998 32/18722 0.826996294860815 0.912264452877311 L1TD1 1 GO:0042219 cellular modified amino acid catabolic process 1/998 32/18722 0.826996294860815 0.912264452877311 PCYOX1 1 GO:0042744 hydrogen peroxide catabolic process 1/998 32/18722 0.826996294860815 0.912264452877311 PRDX4 1 GO:0045684 positive regulation of epidermis development 1/998 32/18722 0.826996294860815 0.912264452877311 NCOA3 1 GO:0061036 positive regulation of cartilage development 1/998 32/18722 0.826996294860815 0.912264452877311 GLI3 1 GO:0072525 pyridine-containing compound biosynthetic process 1/998 32/18722 0.826996294860815 0.912264452877311 QPRT 1 GO:0097345 mitochondrial outer membrane permeabilization 1/998 32/18722 0.826996294860815 0.912264452877311 GSK3B 1 GO:0002820 negative regulation of adaptive immune response 2/998 59/18722 0.829816877475134 0.914024033185163 CD46/CD55 2 GO:0035306 positive regulation of dephosphorylation 2/998 59/18722 0.829816877475134 0.914024033185163 SLC39A10/SPPL3 2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/998 59/18722 0.829816877475134 0.914024033185163 VAV3/PTK2 2 GO:0048278 vesicle docking 2/998 59/18722 0.829816877475134 0.914024033185163 CLN3/USO1 2 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 2/998 59/18722 0.829816877475134 0.914024033185163 SUZ12/ERRFI1 2 GO:0051055 negative regulation of lipid biosynthetic process 2/998 59/18722 0.829816877475134 0.914024033185163 ORMDL1/ACADVL 2 GO:2001258 negative regulation of cation channel activity 2/998 59/18722 0.829816877475134 0.914024033185163 ANK3/FMR1 2 GO:0032945 negative regulation of mononuclear cell proliferation 3/998 84/18722 0.83217968395908 0.916240010533606 DLG5/DLG1/PAWR 3 GO:1900542 regulation of purine nucleotide metabolic process 3/998 84/18722 0.83217968395908 0.916240010533606 APP/PARP1/VCP 3 GO:0009150 purine ribonucleotide metabolic process 16/998 368/18722 0.832442431960951 0.91633606098843 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/CROT/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 16 GO:0006661 phosphatidylinositol biosynthetic process 5/998 131/18722 0.8338612824587 0.916452373546038 PGAP1/CDS1/TMEM150A/PIK3CB/SH3YL1 5 GO:0045089 positive regulation of innate immune response 5/998 131/18722 0.8338612824587 0.916452373546038 CADM1/PRKDC/SFPQ/HSP90AA1/HEXIM1 5 GO:0006336 DNA replication-independent nucleosome assembly 1/998 33/18722 0.836234266916936 0.916452373546038 ATRX 1 GO:0006505 GPI anchor metabolic process 1/998 33/18722 0.836234266916936 0.916452373546038 PGAP1 1 GO:0006536 glutamate metabolic process 1/998 33/18722 0.836234266916936 0.916452373546038 ALDH18A1 1 GO:0009648 photoperiodism 1/998 33/18722 0.836234266916936 0.916452373546038 NR2F6 1 GO:0018345 protein palmitoylation 1/998 33/18722 0.836234266916936 0.916452373546038 ZDHHC17 1 GO:0019362 pyridine nucleotide metabolic process 1/998 33/18722 0.836234266916936 0.916452373546038 QPRT 1 GO:0021696 cerebellar cortex morphogenesis 1/998 33/18722 0.836234266916936 0.916452373546038 OPHN1 1 GO:0032633 interleukin-4 production 1/998 33/18722 0.836234266916936 0.916452373546038 GATA3 1 GO:0032673 regulation of interleukin-4 production 1/998 33/18722 0.836234266916936 0.916452373546038 GATA3 1 GO:0040020 regulation of meiotic nuclear division 1/998 33/18722 0.836234266916936 0.916452373546038 CALR 1 GO:0045920 negative regulation of exocytosis 1/998 33/18722 0.836234266916936 0.916452373546038 FMR1 1 GO:0046320 regulation of fatty acid oxidation 1/998 33/18722 0.836234266916936 0.916452373546038 ACADVL 1 GO:0046496 nicotinamide nucleotide metabolic process 1/998 33/18722 0.836234266916936 0.916452373546038 QPRT 1 GO:0050901 leukocyte tethering or rolling 1/998 33/18722 0.836234266916936 0.916452373546038 ITGB1 1 GO:0070570 regulation of neuron projection regeneration 1/998 33/18722 0.836234266916936 0.916452373546038 LRP1 1 GO:0071763 nuclear membrane organization 1/998 33/18722 0.836234266916936 0.916452373546038 REEP3 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/998 33/18722 0.836234266916936 0.916452373546038 ANK3 1 GO:1903146 regulation of autophagy of mitochondrion 1/998 33/18722 0.836234266916936 0.916452373546038 FZD5 1 GO:1903715 regulation of aerobic respiration 1/998 33/18722 0.836234266916936 0.916452373546038 VCP 1 GO:0031663 lipopolysaccharide-mediated signaling pathway 2/998 60/18722 0.836810124911872 0.916891009898192 CD55/MAPK14 2 GO:0009142 nucleoside triphosphate biosynthetic process 3/998 85/18722 0.838094930430363 0.918106091434521 PARP1/VCP/AK3 3 GO:0071466 cellular response to xenobiotic stimulus 7/998 177/18722 0.838610474563698 0.91847813880786 EGFR/TFRC/HSPA5/ABCA1/TLR3/CYP2J2/NFE2L2 7 GO:0046434 organophosphate catabolic process 6/998 155/18722 0.840090396001893 0.919857706792862 NUDT4/IDH1/SMPDL3A/VCP/GPD1L/PNP 6 GO:0046486 glycerolipid metabolic process 17/998 392/18722 0.841438599826387 0.919857706792862 PGAP1/PISD/HADHA/CDS1/LPCAT3/SLC44A1/CLN3/SLC44A2/TMEM150A/SERINC2/PIK3CB/SH3YL1/SEL1L/PTDSS1/ACSL3/SERINC3/FAR1 17 GO:0072522 purine-containing compound biosynthetic process 8/998 200/18722 0.842216180778334 0.919857706792862 SLC26A2/ACSS1/PARP1/VCP/ACSL3/AK3/TECR/PNP 8 GO:0043966 histone H3 acetylation 2/998 61/18722 0.843542342972178 0.919857706792862 ZNF451/GATA3 2 GO:0006140 regulation of nucleotide metabolic process 3/998 86/18722 0.84382929751782 0.919857706792862 APP/PARP1/VCP 3 GO:0045921 positive regulation of exocytosis 3/998 86/18722 0.84382929751782 0.919857706792862 EXPH5/SYT7/SNX4 3 GO:0030317 flagellated sperm motility 4/998 110/18722 0.844418822818178 0.919857706792862 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0032611 interleukin-1 beta production 4/998 110/18722 0.844418822818178 0.919857706792862 APP/ISL1/ERRFI1/FZD5 4 GO:0032651 regulation of interleukin-1 beta production 4/998 110/18722 0.844418822818178 0.919857706792862 APP/ISL1/ERRFI1/FZD5 4 GO:0097722 sperm motility 4/998 110/18722 0.844418822818178 0.919857706792862 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0046631 alpha-beta T cell activation 6/998 156/18722 0.84441925891121 0.919857706792862 CTSL/CD55/GLI3/GATA3/BCL2/PNP 6 GO:0002446 neutrophil mediated immunity 1/998 34/18722 0.844979421907406 0.919857706792862 ANXA3 1 GO:0006270 DNA replication initiation 1/998 34/18722 0.844979421907406 0.919857706792862 PURA 1 GO:0007095 mitotic G2 DNA damage checkpoint signaling 1/998 34/18722 0.844979421907406 0.919857706792862 FOXO4 1 GO:0007616 long-term memory 1/998 34/18722 0.844979421907406 0.919857706792862 EIF2AK4 1 GO:0009649 entrainment of circadian clock 1/998 34/18722 0.844979421907406 0.919857706792862 NR2F6 1 GO:0010922 positive regulation of phosphatase activity 1/998 34/18722 0.844979421907406 0.919857706792862 SLC39A10 1 GO:0014072 response to isoquinoline alkaloid 1/998 34/18722 0.844979421907406 0.919857706792862 MDM2 1 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/998 34/18722 0.844979421907406 0.919857706792862 DMD 1 GO:0019076 viral release from host cell 1/998 34/18722 0.844979421907406 0.919857706792862 DDB1 1 GO:0030851 granulocyte differentiation 1/998 34/18722 0.844979421907406 0.919857706792862 FASN 1 GO:0034724 DNA replication-independent nucleosome organization 1/998 34/18722 0.844979421907406 0.919857706792862 ATRX 1 GO:0035890 exit from host 1/998 34/18722 0.844979421907406 0.919857706792862 DDB1 1 GO:0035891 exit from host cell 1/998 34/18722 0.844979421907406 0.919857706792862 DDB1 1 GO:0035909 aorta morphogenesis 1/998 34/18722 0.844979421907406 0.919857706792862 LRP1 1 GO:0042573 retinoic acid metabolic process 1/998 34/18722 0.844979421907406 0.919857706792862 ALDH1A3 1 GO:0043278 response to morphine 1/998 34/18722 0.844979421907406 0.919857706792862 MDM2 1 GO:0050869 negative regulation of B cell activation 1/998 34/18722 0.844979421907406 0.919857706792862 PAWR 1 GO:0070050 neuron cellular homeostasis 1/998 34/18722 0.844979421907406 0.919857706792862 ATP2B1 1 GO:1902107 positive regulation of leukocyte differentiation 6/998 157/18722 0.848652507374312 0.923229044407487 CD46/PRKDC/GLI3/MMP14/GATA3/PNP 6 GO:1903708 positive regulation of hemopoiesis 6/998 157/18722 0.848652507374312 0.923229044407487 CD46/PRKDC/GLI3/MMP14/GATA3/PNP 6 GO:0001938 positive regulation of endothelial cell proliferation 4/998 111/18722 0.84938094969968 0.923229044407487 NRP2/NRP1/TGFBR1/EMC10 4 GO:0019646 aerobic electron transport chain 3/998 87/18722 0.849386742275231 0.923229044407487 UQCRC1/NDUFB9/COX6A1 3 GO:1901606 alpha-amino acid catabolic process 3/998 87/18722 0.849386742275231 0.923229044407487 GLDC/ATP2B4/CDO1 3 GO:1903578 regulation of ATP metabolic process 3/998 87/18722 0.849386742275231 0.923229044407487 APP/PARP1/VCP 3 GO:0002260 lymphocyte homeostasis 2/998 62/18722 0.850021454983105 0.923229044407487 BCL2/PMAIP1 2 GO:0019933 cAMP-mediated signaling 2/998 62/18722 0.850021454983105 0.923229044407487 GNAI1/ADGRG6 2 GO:0032757 positive regulation of interleukin-8 production 2/998 62/18722 0.850021454983105 0.923229044407487 TLR3/HSPA1B 2 GO:0046173 polyol biosynthetic process 2/998 62/18722 0.850021454983105 0.923229044407487 ISYNA1/SPTLC3 2 GO:0070265 necrotic cell death 2/998 62/18722 0.850021454983105 0.923229044407487 TLR3/TRPM7 2 GO:0009581 detection of external stimulus 5/998 135/18722 0.852390639488693 0.92405313196003 OPN3/CDS1/CTNNB1/NR2F6/PTK2 5 GO:0019693 ribose phosphate metabolic process 17/998 396/18722 0.852419875809952 0.92405313196003 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/CROT/RPIA/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 17 GO:0071103 DNA conformation change 12/998 290/18722 0.85290767407528 0.92405313196003 RAD50/ATRX/SMARCA5/TOP2B/PURA/HP1BP3/NAV2/DHX36/DDX1/WAPL/CHD6/HNRNPA2B1 12 GO:0003298 physiological muscle hypertrophy 1/998 35/18722 0.853258025125322 0.92405313196003 YY1 1 GO:0003301 physiological cardiac muscle hypertrophy 1/998 35/18722 0.853258025125322 0.92405313196003 YY1 1 GO:0006691 leukotriene metabolic process 1/998 35/18722 0.853258025125322 0.92405313196003 MGST3 1 GO:0009119 ribonucleoside metabolic process 1/998 35/18722 0.853258025125322 0.92405313196003 PNP 1 GO:0019068 virion assembly 1/998 35/18722 0.853258025125322 0.92405313196003 NEDD4 1 GO:0045922 negative regulation of fatty acid metabolic process 1/998 35/18722 0.853258025125322 0.92405313196003 ACADVL 1 GO:0046471 phosphatidylglycerol metabolic process 1/998 35/18722 0.853258025125322 0.92405313196003 HADHA 1 GO:0046640 regulation of alpha-beta T cell proliferation 1/998 35/18722 0.853258025125322 0.92405313196003 CD55 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/998 35/18722 0.853258025125322 0.92405313196003 CHPF 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/998 35/18722 0.853258025125322 0.92405313196003 YY1 1 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1/998 35/18722 0.853258025125322 0.92405313196003 DMD 1 GO:0009141 nucleoside triphosphate metabolic process 4/998 112/18722 0.854208528077823 0.924890652238555 PARP1/SMPDL3A/VCP/AK3 4 GO:0009144 purine nucleoside triphosphate metabolic process 3/998 88/18722 0.854771233394285 0.925116212593608 PARP1/VCP/AK3 3 GO:1901657 glycosyl compound metabolic process 3/998 88/18722 0.854771233394285 0.925116212593608 FUCA1/GUSB/PNP 3 GO:0002429 immune response-activating cell surface receptor signaling pathway 12/998 291/18722 0.855965603186543 0.925571185973287 SLC39A10/CD47/KCNN4/VAV3/PAWR/YES1/EZR/PLEKHA1/PTK2/GATA3/BCL2/SPPL3 12 GO:0002757 immune response-activating signal transduction 12/998 291/18722 0.855965603186543 0.925571185973287 SLC39A10/CD47/KCNN4/VAV3/PAWR/YES1/EZR/PLEKHA1/PTK2/GATA3/BCL2/SPPL3 12 GO:0001756 somitogenesis 2/998 63/18722 0.856255282177931 0.925571185973287 PRKDC/COBL 2 GO:0001947 heart looping 2/998 63/18722 0.856255282177931 0.925571185973287 FOLR1/AHI1 2 GO:0002704 negative regulation of leukocyte mediated immunity 2/998 63/18722 0.856255282177931 0.925571185973287 CD46/CD55 2 GO:0045143 homologous chromosome segregation 2/998 63/18722 0.856255282177931 0.925571185973287 RAD21/SUN1 2 GO:0009260 ribonucleotide biosynthetic process 7/998 182/18722 0.858279340036343 0.927155433954881 SLC26A2/ACSS1/PARP1/VCP/ACSL3/AK3/TECR 7 GO:0009199 ribonucleoside triphosphate metabolic process 3/998 89/18722 0.859986743064475 0.927155433954881 PARP1/VCP/AK3 3 GO:0051781 positive regulation of cell division 3/998 89/18722 0.859986743064475 0.927155433954881 GAREM1/PKN2/FGFR2 3 GO:0060402 calcium ion transport into cytosol 6/998 160/18722 0.860790945543815 0.927155433954881 ATP2B4/MCOLN3/DMD/TRPV6/P2RX4/BCL2 6 GO:0014046 dopamine secretion 1/998 36/18722 0.861094943353231 0.927155433954881 SYT7 1 GO:0014059 regulation of dopamine secretion 1/998 36/18722 0.861094943353231 0.927155433954881 SYT7 1 GO:0016180 snRNA processing 1/998 36/18722 0.861094943353231 0.927155433954881 INTS6 1 GO:0017004 cytochrome complex assembly 1/998 36/18722 0.861094943353231 0.927155433954881 TTC19 1 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 1/998 36/18722 0.861094943353231 0.927155433954881 LRP1 1 GO:0042092 type 2 immune response 1/998 36/18722 0.861094943353231 0.927155433954881 GATA3 1 GO:0042119 neutrophil activation 1/998 36/18722 0.861094943353231 0.927155433954881 ANXA3 1 GO:0043949 regulation of cAMP-mediated signaling 1/998 36/18722 0.861094943353231 0.927155433954881 GNAI1 1 GO:0044060 regulation of endocrine process 1/998 36/18722 0.861094943353231 0.927155433954881 GJA1 1 GO:0051354 negative regulation of oxidoreductase activity 1/998 36/18722 0.861094943353231 0.927155433954881 ATP2B4 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/998 36/18722 0.861094943353231 0.927155433954881 PTPN1 1 GO:0070306 lens fiber cell differentiation 1/998 36/18722 0.861094943353231 0.927155433954881 KDM5B 1 GO:0070897 transcription preinitiation complex assembly 1/998 36/18722 0.861094943353231 0.927155433954881 BDP1 1 GO:0086010 membrane depolarization during action potential 1/998 36/18722 0.861094943353231 0.927155433954881 ANK3 1 GO:0097009 energy homeostasis 1/998 36/18722 0.861094943353231 0.927155433954881 EIF4G1 1 GO:0046854 phosphatidylinositol phosphate biosynthetic process 2/998 64/18722 0.862251532066646 0.927826720717221 TMEM150A/PIK3CB 2 GO:0046888 negative regulation of hormone secretion 2/998 64/18722 0.862251532066646 0.927826720717221 GJA1/RAB11FIP1 2 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 2/998 64/18722 0.862251532066646 0.927826720717221 LRP5/LRP1 2 GO:0002768 immune response-regulating cell surface receptor signaling pathway 13/998 315/18722 0.863253140196084 0.928713093955029 SLC39A10/CD24/CD47/KCNN4/VAV3/PAWR/YES1/EZR/PLEKHA1/PTK2/GATA3/BCL2/SPPL3 13 GO:0022904 respiratory electron transport chain 4/998 114/18722 0.863469935450921 0.928754951172077 PLEC/UQCRC1/NDUFB9/COX6A1 4 GO:0035278 miRNA mediated inhibition of translation 3/998 90/18722 0.865037239434523 0.929777115893382 EIF4G1/AGO2/TNRC6A 3 GO:0040033 negative regulation of translation, ncRNA-mediated 3/998 90/18722 0.865037239434523 0.929777115893382 EIF4G1/AGO2/TNRC6A 3 GO:0070664 negative regulation of leukocyte proliferation 3/998 90/18722 0.865037239434523 0.929777115893382 DLG5/DLG1/PAWR 3 GO:0009582 detection of abiotic stimulus 5/998 138/18722 0.865132585521941 0.929777115893382 OPN3/CDS1/CTNNB1/NR2F6/PTK2 5 GO:0090630 activation of GTPase activity 4/998 115/18722 0.867908753301335 0.931684842457279 CCDC125/SYDE2/NEDD9/EVI5 4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/998 37/18722 0.868513719256767 0.931684842457279 RPS21 1 GO:0021532 neural tube patterning 1/998 37/18722 0.868513719256767 0.931684842457279 GLI3 1 GO:0030513 positive regulation of BMP signaling pathway 1/998 37/18722 0.868513719256767 0.931684842457279 GPC3 1 GO:0033260 nuclear DNA replication 1/998 37/18722 0.868513719256767 0.931684842457279 ATRX 1 GO:0042178 xenobiotic catabolic process 1/998 37/18722 0.868513719256767 0.931684842457279 CYP2J2 1 GO:0051954 positive regulation of amine transport 1/998 37/18722 0.868513719256767 0.931684842457279 ITGB1 1 GO:0072529 pyrimidine-containing compound catabolic process 1/998 37/18722 0.868513719256767 0.931684842457279 TET2 1 GO:0097484 dendrite extension 1/998 37/18722 0.868513719256767 0.931684842457279 SPAG9 1 GO:0043433 negative regulation of DNA-binding transcription factor activity 7/998 185/18722 0.869114615621675 0.932137922793913 BMP7/UFL1/PURA/EIF2AK4/FZD6/TCF7L2/HDAC2 7 GO:0045333 cellular respiration 9/998 230/18722 0.869785326215901 0.932434242339533 IL10RB/IDH1/OPN3/VCP/PLEC/ACO1/UQCRC1/NDUFB9/COX6A1 9 GO:0019935 cyclic-nucleotide-mediated signaling 3/998 91/18722 0.869926679646785 0.932434242339533 NUDT4/GNAI1/ADGRG6 3 GO:0045974 regulation of translation, ncRNA-mediated 3/998 91/18722 0.869926679646785 0.932434242339533 EIF4G1/AGO2/TNRC6A 3 GO:0042446 hormone biosynthetic process 2/998 66/18722 0.873561502133945 0.935714070374868 HSD17B1/STC2 2 GO:0006497 protein lipidation 3/998 92/18722 0.874659003416758 0.935714070374868 PGAP1/ABCA1/ZDHHC17 3 GO:0002385 mucosal immune response 1/998 38/18722 0.875536641824695 0.935714070374868 OTUD7B 1 GO:0007094 mitotic spindle assembly checkpoint signaling 1/998 38/18722 0.875536641824695 0.935714070374868 TPR 1 GO:0009595 detection of biotic stimulus 1/998 38/18722 0.875536641824695 0.935714070374868 YAP1 1 GO:0032717 negative regulation of interleukin-8 production 1/998 38/18722 0.875536641824695 0.935714070374868 OTUD7B 1 GO:0046633 alpha-beta T cell proliferation 1/998 38/18722 0.875536641824695 0.935714070374868 CD55 1 GO:0048246 macrophage chemotaxis 1/998 38/18722 0.875536641824695 0.935714070374868 PTK2 1 GO:0051930 regulation of sensory perception of pain 1/998 38/18722 0.875536641824695 0.935714070374868 SLC9A1 1 GO:0071173 spindle assembly checkpoint signaling 1/998 38/18722 0.875536641824695 0.935714070374868 TPR 1 GO:0071174 mitotic spindle checkpoint signaling 1/998 38/18722 0.875536641824695 0.935714070374868 TPR 1 GO:0071398 cellular response to fatty acid 1/998 38/18722 0.875536641824695 0.935714070374868 ASS1 1 GO:1901186 positive regulation of ERBB signaling pathway 1/998 38/18722 0.875536641824695 0.935714070374868 RTN4 1 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1/998 38/18722 0.875536641824695 0.935714070374868 GSK3B 1 GO:0022412 cellular process involved in reproduction in multicellular organism 16/998 384/18722 0.875674956493317 0.935714070374868 LGR5/SMARCA2/ITGB1/SPESP1/DIAPH2/ZFX/HEXB/FOLR1/DNMT3A/PRDX4/TGFBR1/JAM3/CTNNB1/BCL2/QKI/TMF1 16 GO:0030183 B cell differentiation 5/998 141/18722 0.876936342035644 0.936678527366632 ITGB1/PRKDC/MMP14/BCL2/YY1 5 GO:0034341 response to interferon-gamma 5/998 141/18722 0.876936342035644 0.936678527366632 CD47/TLR3/PPARG/MYO1C/ASS1 5 GO:0009259 ribonucleotide metabolic process 16/998 385/18722 0.878055759109466 0.937682372327781 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/CROT/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 16 GO:0006513 protein monoubiquitination 2/998 67/18722 0.878889984665397 0.937794129059957 DDB1/HUWE1 2 GO:0009583 detection of light stimulus 2/998 67/18722 0.878889984665397 0.937794129059957 OPN3/CDS1 2 GO:0061371 determination of heart left/right asymmetry 2/998 67/18722 0.878889984665397 0.937794129059957 FOLR1/AHI1 2 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 2/998 67/18722 0.878889984665397 0.937794129059957 CD55/GATA3 2 GO:0033108 mitochondrial respiratory chain complex assembly 3/998 93/18722 0.879238127130529 0.937794129059957 TFAM/TTC19/NDUFB9 3 GO:0045132 meiotic chromosome segregation 3/998 93/18722 0.879238127130529 0.937794129059957 TOP2B/RAD21/SUN1 3 GO:0007613 memory 4/998 118/18722 0.880487793124252 0.93893520586228 SLC6A4/SERPINF1/EIF2AK4/PLK2 4 GO:0002701 negative regulation of production of molecular mediator of immune response 1/998 39/18722 0.882184813065273 0.939018737821364 PRKDC 1 GO:0031577 spindle checkpoint signaling 1/998 39/18722 0.882184813065273 0.939018737821364 TPR 1 GO:0032506 cytokinetic process 1/998 39/18722 0.882184813065273 0.939018737821364 PLEC 1 GO:0036297 interstrand cross-link repair 1/998 39/18722 0.882184813065273 0.939018737821364 VCP 1 GO:0043267 negative regulation of potassium ion transport 1/998 39/18722 0.882184813065273 0.939018737821364 ANK3 1 GO:0045923 positive regulation of fatty acid metabolic process 1/998 39/18722 0.882184813065273 0.939018737821364 PPARG 1 GO:0051931 regulation of sensory perception 1/998 39/18722 0.882184813065273 0.939018737821364 SLC9A1 1 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 1/998 39/18722 0.882184813065273 0.939018737821364 SLC9A1 1 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 1/998 39/18722 0.882184813065273 0.939018737821364 CD55 1 GO:0019221 cytokine-mediated signaling pathway 20/998 472/18722 0.88271872640305 0.939395530075484 CSF3R/P4HB/CSF2RA/CD24/PRLR/SPPL2A/IL10RB/YAP1/IL6ST/TRIM44/RPS6KA5/ACTN4/PTPN1/PPARG/KRAS/SPPL2B/HSPA1B/LIFR/OTUD4/KRT18 20 GO:1903035 negative regulation of response to wounding 3/998 94/18722 0.883667938433762 0.939812319924621 GJA1/PHLDB2/ANXA2 3 GO:0002263 cell activation involved in immune response 11/998 279/18722 0.883707314597755 0.939812319924621 APP/CD46/TFRC/LRP1/HSPD1/SWAP70/EIF2AK4/RIF1/GATA3/SNX4/ANXA3 11 GO:0030217 T cell differentiation 10/998 257/18722 0.883966802176264 0.939812319924621 CD46/CTSL/PRKDC/GLI3/CTNNB1/FZD5/GATA3/BCL2/PNP/KDELR1 10 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 2/998 68/18722 0.884010400909751 0.939812319924621 PARP1/VCP 2 GO:0051926 negative regulation of calcium ion transport 2/998 68/18722 0.884010400909751 0.939812319924621 FMR1/BCL2 2 GO:0046390 ribose phosphate biosynthetic process 7/998 190/18722 0.885651748446901 0.940921854047538 SLC26A2/ACSS1/PARP1/VCP/ACSL3/AK3/TECR 7 GO:0034728 nucleosome organization 6/998 167/18722 0.886005938972702 0.940921854047538 ATRX/BPTF/SMARCA5/SETD2/HP1BP3/SMARCC1 6 GO:0031348 negative regulation of defense response 10/998 258/18722 0.886688323339877 0.940921854047538 SERPINF1/ASH1L/ISL1/LPCAT3/YES1/PPARG/MAPK14/GATA3/PLK2/VPS35 10 GO:0010324 membrane invagination 5/998 144/18722 0.887849874858077 0.940921854047538 ANO6/FNBP1L/ABCA1/RAB31/DOCK1 5 GO:0042773 ATP synthesis coupled electron transport 3/998 95/18722 0.887952291286605 0.940921854047538 UQCRC1/NDUFB9/COX6A1 3 GO:0042775 mitochondrial ATP synthesis coupled electron transport 3/998 95/18722 0.887952291286605 0.940921854047538 UQCRC1/NDUFB9/COX6A1 3 GO:0002761 regulation of myeloid leukocyte differentiation 4/998 120/18722 0.88828446148693 0.940921854047538 FBN1/CDK6/TLR3/CTNNB1 4 GO:0006730 one-carbon metabolic process 1/998 40/18722 0.888478211157702 0.940921854047538 AHCYL1 1 GO:0007339 binding of sperm to zona pellucida 1/998 40/18722 0.888478211157702 0.940921854047538 B4GALT1 1 GO:0009394 2'-deoxyribonucleotide metabolic process 1/998 40/18722 0.888478211157702 0.940921854047538 PNP 1 GO:0010543 regulation of platelet activation 1/998 40/18722 0.888478211157702 0.940921854047538 IL6ST 1 GO:0010863 positive regulation of phospholipase C activity 1/998 40/18722 0.888478211157702 0.940921854047538 EGFR 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization 1/998 40/18722 0.888478211157702 0.940921854047538 CAMSAP2 1 GO:0042073 intraciliary transport 1/998 40/18722 0.888478211157702 0.940921854047538 PCM1 1 GO:0071276 cellular response to cadmium ion 1/998 40/18722 0.888478211157702 0.940921854047538 EGFR 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/998 40/18722 0.888478211157702 0.940921854047538 FMR1 1 GO:1901223 negative regulation of NIK/NF-kappaB signaling 1/998 40/18722 0.888478211157702 0.940921854047538 BMP7 1 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 1/998 40/18722 0.888478211157702 0.940921854047538 GSK3B 1 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 1/998 40/18722 0.888478211157702 0.940921854047538 NFAT5 1 GO:0006164 purine nucleotide biosynthetic process 7/998 191/18722 0.888740498948102 0.941008749748132 SLC26A2/ACSS1/PARP1/VCP/ACSL3/AK3/TECR 7 GO:0009145 purine nucleoside triphosphate biosynthetic process 2/998 69/18722 0.888929764435409 0.94101830902621 PARP1/VCP 2 GO:0042158 lipoprotein biosynthetic process 3/998 96/18722 0.892095001459677 0.944177580097501 PGAP1/ABCA1/ZDHHC17 3 GO:0002831 regulation of response to biotic stimulus 13/998 327/18722 0.893895678214232 0.945696446342472 CADM1/CD55/PRKDC/HSPD1/TRIM44/PUM1/SFPQ/ANKRD17/PTPN1/PPARG/HSP90AA1/EIF2AK4/HEXIM1 13 GO:0002251 organ or tissue specific immune response 1/998 41/18722 0.894435750246912 0.945696446342472 OTUD7B 1 GO:0006418 tRNA aminoacylation for protein translation 1/998 41/18722 0.894435750246912 0.945696446342472 IARS2 1 GO:0030488 tRNA methylation 1/998 41/18722 0.894435750246912 0.945696446342472 TARBP1 1 GO:0044786 cell cycle DNA replication 1/998 41/18722 0.894435750246912 0.945696446342472 ATRX 1 GO:0050868 negative regulation of T cell activation 4/998 122/18722 0.895633030634924 0.946387381692964 DLG5/DLG1/GLI3/PAWR 4 GO:0051208 sequestering of calcium ion 4/998 122/18722 0.895633030634924 0.946387381692964 HSP90B1/CALR/MCOLN3/DMD 4 GO:0051928 positive regulation of calcium ion transport 4/998 122/18722 0.895633030634924 0.946387381692964 ATP2B1/SLC9A1/HOMER1/P2RX4 4 GO:0002285 lymphocyte activation involved in immune response 7/998 194/18722 0.897588967307159 0.94807040224776 CD46/TFRC/HSPD1/SWAP70/EIF2AK4/RIF1/GATA3 7 GO:0050777 negative regulation of immune response 7/998 194/18722 0.897588967307159 0.94807040224776 CD46/CD55/YES1/CD59/PPARG/MAPK14/PLK2 7 GO:0043550 regulation of lipid kinase activity 2/998 71/18722 0.898192606046375 0.948202852056049 VAV3/PTK2 2 GO:0050851 antigen receptor-mediated signaling pathway 9/998 240/18722 0.898308798949981 0.948202852056049 SLC39A10/KCNN4/VAV3/PAWR/EZR/PLEKHA1/GATA3/BCL2/SPPL3 9 GO:0014003 oligodendrocyte development 1/998 42/18722 0.900075337059908 0.948202852056049 NCSTN 1 GO:0019692 deoxyribose phosphate metabolic process 1/998 42/18722 0.900075337059908 0.948202852056049 PNP 1 GO:0032467 positive regulation of cytokinesis 1/998 42/18722 0.900075337059908 0.948202852056049 PKN2 1 GO:0032689 negative regulation of interferon-gamma production 1/998 42/18722 0.900075337059908 0.948202852056049 GATA3 1 GO:0032691 negative regulation of interleukin-1 beta production 1/998 42/18722 0.900075337059908 0.948202852056049 ERRFI1 1 GO:0033003 regulation of mast cell activation 1/998 42/18722 0.900075337059908 0.948202852056049 SNX4 1 GO:0033574 response to testosterone 1/998 42/18722 0.900075337059908 0.948202852056049 CALR 1 GO:0046596 regulation of viral entry into host cell 1/998 42/18722 0.900075337059908 0.948202852056049 P4HB 1 GO:0048489 synaptic vesicle transport 1/998 42/18722 0.900075337059908 0.948202852056049 CTNNB1 1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 1/998 42/18722 0.900075337059908 0.948202852056049 DCP2 1 GO:1900274 regulation of phospholipase C activity 1/998 42/18722 0.900075337059908 0.948202852056049 EGFR 1 GO:0002440 production of molecular mediator of immune response 12/998 308/18722 0.900675173799348 0.948643349285132 TFRC/CD55/PRKDC/HSPD1/TLR3/SWAP70/RIF1/DHX36/FZD5/DDX1/GATA3/YY1 12 GO:0030098 lymphocyte differentiation 15/998 374/18722 0.901288240701613 0.949097600787237 CD46/CTSL/ITGB1/PBX1/PRKDC/HECTD1/GLI3/CTNNB1/FZD5/MMP14/GATA3/BCL2/YY1/PNP/KDELR1 15 GO:0006163 purine nucleotide metabolic process 16/998 396/18722 0.901926586350544 0.949578283391044 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/CROT/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 16 GO:0000045 autophagosome assembly 3/998 99/18722 0.903710777673582 0.951073164731661 GABARAPL1/TMEM41B/ATP2A2 3 GO:0031341 regulation of cell killing 3/998 99/18722 0.903710777673582 0.951073164731661 CADM1/CD55/CD59 3 GO:0045834 positive regulation of lipid metabolic process 5/998 149/18722 0.904192456396525 0.951388314156844 VAV3/SORBS1/PPARG/PTK2/ACSL3 5 GO:0036230 granulocyte activation 1/998 43/18722 0.905413924512489 0.951714535912967 ANXA3 1 GO:0042181 ketone biosynthetic process 1/998 43/18722 0.905413924512489 0.951714535912967 HSD17B1 1 GO:0045494 photoreceptor cell maintenance 1/998 43/18722 0.905413924512489 0.951714535912967 SLC2A1 1 GO:0046636 negative regulation of alpha-beta T cell activation 1/998 43/18722 0.905413924512489 0.951714535912967 GLI3 1 GO:0120178 steroid hormone biosynthetic process 1/998 43/18722 0.905413924512489 0.951714535912967 HSD17B1 1 GO:0060294 cilium movement involved in cell motility 4/998 125/18722 0.905859047601173 0.95199075835864 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0042274 ribosomal small subunit biogenesis 2/998 73/18722 0.906731450442988 0.952140969984481 PRKDC/RPS21 2 GO:0043299 leukocyte degranulation 2/998 73/18722 0.906731450442988 0.952140969984481 SNX4/ANXA3 2 GO:0051298 centrosome duplication 2/998 73/18722 0.906731450442988 0.952140969984481 CEP152/PLK2 2 GO:0051865 protein autoubiquitination 2/998 73/18722 0.906731450442988 0.952140969984481 MDM2/HECTD1 2 GO:0045619 regulation of lymphocyte differentiation 6/998 174/18722 0.907244086936532 0.952487709208854 CD46/PRKDC/GLI3/MMP14/GATA3/PNP 6 GO:0071219 cellular response to molecule of bacterial origin 8/998 221/18722 0.907943702447189 0.953030573075347 CD55/ABCA1/MAPK14/FZD5/ASS1/PDCD4/PRPF8/PABPN1 8 GO:0050864 regulation of B cell activation 7/998 198/18722 0.908453174227326 0.953373672892637 TFRC/SLC39A10/VAV3/PAWR/RIF1/MMP14/BCL2 7 GO:0009262 deoxyribonucleotide metabolic process 1/998 44/18722 0.910467562466156 0.954145151271738 PNP 1 GO:0021762 substantia nigra development 1/998 44/18722 0.910467562466156 0.954145151271738 HSPA5 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/998 44/18722 0.910467562466156 0.954145151271738 CADM1 1 GO:0042554 superoxide anion generation 1/998 44/18722 0.910467562466156 0.954145151271738 EGFR 1 GO:0043039 tRNA aminoacylation 1/998 44/18722 0.910467562466156 0.954145151271738 IARS2 1 GO:0046006 regulation of activated T cell proliferation 1/998 44/18722 0.910467562466156 0.954145151271738 CD24 1 GO:0150076 neuroinflammatory response 1/998 44/18722 0.910467562466156 0.954145151271738 ITGB1 1 GO:0009201 ribonucleoside triphosphate biosynthetic process 2/998 74/18722 0.910745205469974 0.954244575107111 PARP1/VCP 2 GO:0006911 phagocytosis, engulfment 4/998 127/18722 0.912173601332464 0.955549432695986 ANO6/ABCA1/RAB31/DOCK1 4 GO:0090501 RNA phosphodiester bond hydrolysis 5/998 152/18722 0.912968684681924 0.956190471960747 SND1/DCP2/DICER1/AGO2/RPS21 5 GO:0010522 regulation of calcium ion transport into cytosol 3/998 102/18722 0.914184687675775 0.956470736279364 DMD/P2RX4/BCL2 3 GO:0032677 regulation of interleukin-8 production 3/998 102/18722 0.914184687675775 0.956470736279364 TLR3/HSPA1B/OTUD7B 3 GO:0034308 primary alcohol metabolic process 3/998 102/18722 0.914184687675775 0.956470736279364 ACSS1/ADH5/ALDH1A3 3 GO:0035710 CD4-positive, alpha-beta T cell activation 3/998 102/18722 0.914184687675775 0.956470736279364 CTSL/CD55/GATA3 3 GO:0002292 T cell differentiation involved in immune response 2/998 75/18722 0.914596629895739 0.956470736279364 CD46/GATA3 2 GO:0006333 chromatin assembly or disassembly 6/998 177/18722 0.915245318620477 0.956470736279364 ATRX/TLK1/SMARCA5/HP1BP3/BAZ1B/SMARCC1 6 GO:0006110 regulation of glycolytic process 1/998 45/18722 0.915251445786574 0.956470736279364 APP 1 GO:0010824 regulation of centrosome duplication 1/998 45/18722 0.915251445786574 0.956470736279364 PLK2 1 GO:0043038 amino acid activation 1/998 45/18722 0.915251445786574 0.956470736279364 IARS2 1 GO:0045910 negative regulation of DNA recombination 1/998 45/18722 0.915251445786574 0.956470736279364 RIF1 1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 1/998 45/18722 0.915251445786574 0.956470736279364 GSK3B 1 GO:0009135 purine nucleoside diphosphate metabolic process 3/998 103/18722 0.917438769172645 0.958137879037923 APP/DLG1/AK3 3 GO:0009179 purine ribonucleoside diphosphate metabolic process 3/998 103/18722 0.917438769172645 0.958137879037923 APP/DLG1/AK3 3 GO:0032637 interleukin-8 production 3/998 103/18722 0.917438769172645 0.958137879037923 TLR3/HSPA1B/OTUD7B 3 GO:0007127 meiosis I 4/998 129/18722 0.918108195404978 0.958137879037923 RAD50/TOP2B/RAD21/SUN1 4 GO:0032543 mitochondrial translation 2/998 76/18722 0.918291602886422 0.958137879037923 IARS2/LRPPRC 2 GO:0032720 negative regulation of tumor necrosis factor production 2/998 76/18722 0.918291602886422 0.958137879037923 DICER1/ERRFI1 2 GO:0017157 regulation of exocytosis 7/998 202/18722 0.918314871998806 0.958137879037923 EXPH5/SYT7/TRPV6/FMR1/ATP2A2/GSK3B/SNX4 7 GO:1903046 meiotic cell cycle process 7/998 202/18722 0.918314871998806 0.958137879037923 CALR/RAD50/ATRX/TOP2B/RAD21/SUN1/GOLGA2 7 GO:0007019 microtubule depolymerization 1/998 46/18722 0.919779959846916 0.958517199672804 CAMSAP2 1 GO:0032924 activin receptor signaling pathway 1/998 46/18722 0.919779959846916 0.958517199672804 TGFBR1 1 GO:0043300 regulation of leukocyte degranulation 1/998 46/18722 0.919779959846916 0.958517199672804 SNX4 1 GO:0043462 regulation of ATPase activity 1/998 46/18722 0.919779959846916 0.958517199672804 TOR1AIP2 1 GO:0044818 mitotic G2/M transition checkpoint 1/998 46/18722 0.919779959846916 0.958517199672804 FOXO4 1 GO:0090329 regulation of DNA-dependent DNA replication 1/998 46/18722 0.919779959846916 0.958517199672804 ATRX 1 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 3/998 104/18722 0.920579946170584 0.95915942904742 TGM2/HOMER1/GPR157 3 GO:0050853 B cell receptor signaling pathway 4/998 131/18722 0.923681442536638 0.961066207963576 SLC39A10/VAV3/PLEKHA1/BCL2 4 GO:0016073 snRNA metabolic process 1/998 47/18722 0.924066723611789 0.961066207963576 INTS6 1 GO:0032008 positive regulation of TOR signaling 1/998 47/18722 0.924066723611789 0.961066207963576 SLC38A9 1 GO:0045581 negative regulation of T cell differentiation 1/998 47/18722 0.924066723611789 0.961066207963576 GLI3 1 GO:0050798 activated T cell proliferation 1/998 47/18722 0.924066723611789 0.961066207963576 CD24 1 GO:0097028 dendritic cell differentiation 1/998 47/18722 0.924066723611789 0.961066207963576 ITGB8 1 GO:0101023 vascular endothelial cell proliferation 1/998 47/18722 0.924066723611789 0.961066207963576 PPARG 1 GO:1903170 negative regulation of calcium ion transmembrane transport 1/998 47/18722 0.924066723611789 0.961066207963576 FMR1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/998 47/18722 0.924066723611789 0.961066207963576 PPARG 1 GO:0043537 negative regulation of blood vessel endothelial cell migration 2/998 78/18722 0.925234888230536 0.961706420754853 ATP2B4/PPARG 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2/998 78/18722 0.925234888230536 0.961706420754853 NRP1/PLK2 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 2/998 78/18722 0.925234888230536 0.961706420754853 DICER1/ERRFI1 2 GO:0009185 ribonucleoside diphosphate metabolic process 3/998 106/18722 0.926536846598918 0.962676393252329 APP/DLG1/AK3 3 GO:0042116 macrophage activation 3/998 106/18722 0.926536846598918 0.962676393252329 APP/HSPD1/TLR3 3 GO:0051260 protein homooligomerization 6/998 182/18722 0.927248764712564 0.963176047600184 FUS/SLC1A5/GOLGA2/ALDH1A3/KCTD3/ALAD 6 GO:0002715 regulation of natural killer cell mediated immunity 1/998 48/18722 0.928124630430286 0.963176047600184 CADM1 1 GO:0030261 chromosome condensation 1/998 48/18722 0.928124630430286 0.963176047600184 WAPL 1 GO:0043303 mast cell degranulation 1/998 48/18722 0.928124630430286 0.963176047600184 SNX4 1 GO:0044458 motile cilium assembly 1/998 48/18722 0.928124630430286 0.963176047600184 ATMIN 1 GO:0090311 regulation of protein deacetylation 1/998 48/18722 0.928124630430286 0.963176047600184 NIPBL 1 GO:0009855 determination of bilateral symmetry 4/998 133/18722 0.928911477295536 0.963609541617324 GALNT11/FOLR1/AHI1/CTNNB1 4 GO:0010565 regulation of cellular ketone metabolic process 4/998 133/18722 0.928911477295536 0.963609541617324 ATP2B4/ACADVL/CLN3/PPARG 4 GO:0009165 nucleotide biosynthetic process 9/998 254/18722 0.92931384392227 0.963833686068194 SLC26A2/ACSS1/PARP1/QPRT/VCP/ACSL3/AK3/TECR/PNP 9 GO:0046488 phosphatidylinositol metabolic process 5/998 159/18722 0.930749898481675 0.963833686068194 PGAP1/CDS1/TMEM150A/PIK3CB/SH3YL1 5 GO:1903169 regulation of calcium ion transmembrane transport 5/998 159/18722 0.930749898481675 0.963833686068194 AHNAK/DMD/SLC9A1/TSPAN13/FMR1 5 GO:0007281 germ cell development 10/998 278/18722 0.930959952060574 0.963833686068194 LGR5/SMARCA2/DIAPH2/ZFX/HEXB/JAM3/CTNNB1/BCL2/QKI/TMF1 10 GO:0009799 specification of symmetry 4/998 134/18722 0.931403316683974 0.963833686068194 GALNT11/FOLR1/AHI1/CTNNB1 4 GO:0002279 mast cell activation involved in immune response 1/998 49/18722 0.931965886659834 0.963833686068194 SNX4 1 GO:0006692 prostanoid metabolic process 1/998 49/18722 0.931965886659834 0.963833686068194 ATP6V1B1 1 GO:0006693 prostaglandin metabolic process 1/998 49/18722 0.931965886659834 0.963833686068194 ATP6V1B1 1 GO:0006953 acute-phase response 1/998 49/18722 0.931965886659834 0.963833686068194 ASS1 1 GO:0009395 phospholipid catabolic process 1/998 49/18722 0.931965886659834 0.963833686068194 IDH1 1 GO:0030195 negative regulation of blood coagulation 1/998 49/18722 0.931965886659834 0.963833686068194 ANXA2 1 GO:0032692 negative regulation of interleukin-1 production 1/998 49/18722 0.931965886659834 0.963833686068194 ERRFI1 1 GO:0042304 regulation of fatty acid biosynthetic process 1/998 49/18722 0.931965886659834 0.963833686068194 ACADVL 1 GO:0046605 regulation of centrosome cycle 1/998 49/18722 0.931965886659834 0.963833686068194 PLK2 1 GO:0051445 regulation of meiotic cell cycle 1/998 49/18722 0.931965886659834 0.963833686068194 CALR 1 GO:0140053 mitochondrial gene expression 3/998 108/18722 0.932081264309196 0.963833686068194 IARS2/LRPPRC/TFAM 3 GO:1902105 regulation of leukocyte differentiation 10/998 279/18722 0.932716555683727 0.964227851133171 FBN1/CD46/CDK6/PRKDC/GLI3/TLR3/CTNNB1/MMP14/GATA3/PNP 10 GO:1901293 nucleoside phosphate biosynthetic process 9/998 256/18722 0.932999218266696 0.964227851133171 SLC26A2/ACSS1/PARP1/QPRT/VCP/ACSL3/AK3/TECR/PNP 9 GO:0071222 cellular response to lipopolysaccharide 7/998 209/18722 0.933370185578431 0.964227851133171 CD55/ABCA1/MAPK14/ASS1/PDCD4/PRPF8/PABPN1 7 GO:0140013 meiotic nuclear division 6/998 185/18722 0.933709876938884 0.964227851133171 CALR/RAD50/TOP2B/RAD21/SUN1/GOLGA2 6 GO:0061982 meiosis I cell cycle process 4/998 135/18722 0.933815917514364 0.964227851133171 RAD50/TOP2B/RAD21/SUN1 4 GO:0001960 negative regulation of cytokine-mediated signaling pathway 2/998 81/18722 0.934613990820544 0.964227851133171 PPARG/OTUD4 2 GO:0072521 purine-containing compound metabolic process 16/998 416/18722 0.935528886587538 0.964227851133171 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/CROT/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 16 GO:0000387 spliceosomal snRNP assembly 1/998 50/18722 0.935602048236093 0.964227851133171 PRPF8 1 GO:0002448 mast cell mediated immunity 1/998 50/18722 0.935602048236093 0.964227851133171 SNX4 1 GO:0006220 pyrimidine nucleotide metabolic process 1/998 50/18722 0.935602048236093 0.964227851133171 AK3 1 GO:0015872 dopamine transport 1/998 50/18722 0.935602048236093 0.964227851133171 SYT7 1 GO:0019083 viral transcription 1/998 50/18722 0.935602048236093 0.964227851133171 HEXIM1 1 GO:0030490 maturation of SSU-rRNA 1/998 50/18722 0.935602048236093 0.964227851133171 RPS21 1 GO:0042572 retinol metabolic process 1/998 50/18722 0.935602048236093 0.964227851133171 ALDH1A3 1 GO:0060337 type I interferon signaling pathway 1/998 50/18722 0.935602048236093 0.964227851133171 PTPN1 1 GO:0090102 cochlea development 1/998 50/18722 0.935602048236093 0.964227851133171 GATA3 1 GO:1900047 negative regulation of hemostasis 1/998 50/18722 0.935602048236093 0.964227851133171 ANXA2 1 GO:0099024 plasma membrane invagination 4/998 136/18722 0.936151396231659 0.964603599708997 ANO6/ABCA1/RAB31/DOCK1 4 GO:0006939 smooth muscle contraction 3/998 110/18722 0.937238024344323 0.965342222351886 ATP2B1/DLG1/ATP2B4 3 GO:0009063 cellular amino acid catabolic process 3/998 110/18722 0.937238024344323 0.965342222351886 GLDC/ATP2B4/CDO1 3 GO:0046889 positive regulation of lipid biosynthetic process 2/998 82/18722 0.937484569687939 0.965405707759513 SORBS1/ACSL3 2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/998 51/18722 0.939044055298024 0.966249312714029 NDUFB9 1 GO:0006636 unsaturated fatty acid biosynthetic process 1/998 51/18722 0.939044055298024 0.966249312714029 DEGS1 1 GO:0009584 detection of visible light 1/998 51/18722 0.939044055298024 0.966249312714029 OPN3 1 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 1/998 51/18722 0.939044055298024 0.966249312714029 GATA3 1 GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/998 83/18722 0.940235309150385 0.967087201329972 CTSL/GATA3 2 GO:0061053 somite development 2/998 83/18722 0.940235309150385 0.967087201329972 PRKDC/COBL 2 GO:0001539 cilium or flagellum-dependent cell motility 4/998 138/18722 0.940599273770081 0.967087201329972 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0060285 cilium-dependent cell motility 4/998 138/18722 0.940599273770081 0.967087201329972 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0090305 nucleic acid phosphodiester bond hydrolysis 9/998 261/18722 0.941491587959032 0.967664983017861 N4BP2/SND1/RAD50/DCP2/DICER1/DDX1/AGO2/XPC/RPS21 9 GO:0009060 aerobic respiration 6/998 189/18722 0.941531912225768 0.967664983017861 IDH1/VCP/ACO1/UQCRC1/NDUFB9/COX6A1 6 GO:0071357 cellular response to type I interferon 1/998 52/18722 0.942302264971452 0.96826611403581 PTPN1 1 GO:0009953 dorsal/ventral pattern formation 2/998 84/18722 0.942870812203831 0.9684691147976 GLI3/CTNNB1 2 GO:0015844 monoamine transport 2/998 84/18722 0.942870812203831 0.9684691147976 SLC6A4/SYT7 2 GO:0032635 interleukin-6 production 5/998 165/18722 0.943332294583495 0.968562027535974 APP/CD47/HSPD1/ISL1/TLR3 5 GO:0032675 regulation of interleukin-6 production 5/998 165/18722 0.943332294583495 0.968562027535974 APP/CD47/HSPD1/ISL1/TLR3 5 GO:0007601 visual perception 7/998 215/18722 0.944276887061864 0.969341255869051 EFEMP1/TACSTD2/MYO7A/CRYBG3/KIFC3/RP2/ATF6 7 GO:0043113 receptor clustering 1/998 53/18722 0.945386482408972 0.969917483564417 DLG1 1 GO:0097479 synaptic vesicle localization 1/998 53/18722 0.945386482408972 0.969917483564417 CTNNB1 1 GO:0097194 execution phase of apoptosis 2/998 85/18722 0.945395532246565 0.969917483564417 DICER1/BLCAP 2 GO:0042113 B cell activation 12/998 334/18722 0.946473276875964 0.97065119658648 TFRC/ITGB1/SLC39A10/PRKDC/VAV3/HSPD1/PAWR/SWAP70/RIF1/MMP14/BCL2/YY1 12 GO:0002286 T cell activation involved in immune response 3/998 114/18722 0.946482520938857 0.97065119658648 CD46/EIF2AK4/GATA3 3 GO:0006119 oxidative phosphorylation 4/998 141/18722 0.946743500861869 0.970728165357388 VCP/UQCRC1/NDUFB9/COX6A1 4 GO:0060761 negative regulation of response to cytokine stimulus 2/998 86/18722 0.947813775930583 0.97137641254145 PPARG/OTUD4 2 GO:0006584 catecholamine metabolic process 1/998 54/18722 0.948305990178849 0.97137641254145 GATA3 1 GO:0009712 catechol-containing compound metabolic process 1/998 54/18722 0.948305990178849 0.97137641254145 GATA3 1 GO:0010524 positive regulation of calcium ion transport into cytosol 1/998 54/18722 0.948305990178849 0.97137641254145 P2RX4 1 GO:0043647 inositol phosphate metabolic process 1/998 54/18722 0.948305990178849 0.97137641254145 NUDT4 1 GO:0097553 calcium ion transmembrane import into cytosol 4/998 142/18722 0.94865865418161 0.971547044621849 ATP2B4/MCOLN3/DMD/TRPV6 4 GO:0045088 regulation of innate immune response 7/998 218/18722 0.949111506238998 0.97182019495466 CADM1/PRKDC/SFPQ/PTPN1/PPARG/HSP90AA1/HEXIM1 7 GO:0060271 cilium assembly 12/998 337/18722 0.95033881163063 0.972810676717876 GALNT11/LAMA5/YAP1/FNBP1L/DYNLL2/ATMIN/CDKL5/LIMK2/AHI1/PCM1/RP2/MAP4 12 GO:0033559 unsaturated fatty acid metabolic process 3/998 116/18722 0.950614543144288 0.972810676717876 DEGS1/ATP6V1B1/CYP2J2 3 GO:0050953 sensory perception of light stimulus 7/998 219/18722 0.950637822757059 0.972810676717876 EFEMP1/TACSTD2/MYO7A/CRYBG3/KIFC3/RP2/ATF6 7 GO:0045620 negative regulation of lymphocyte differentiation 1/998 55/18722 0.951069576090651 0.973061778712382 GLI3 1 GO:0030101 natural killer cell activation 2/998 88/18722 0.952347345035168 0.974178191306546 PBX1/HECTD1 2 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/998 56/18722 0.953685559540671 0.974592348084135 CADM1 1 GO:0043470 regulation of carbohydrate catabolic process 1/998 56/18722 0.953685559540671 0.974592348084135 APP 1 GO:0045071 negative regulation of viral genome replication 1/998 56/18722 0.953685559540671 0.974592348084135 MPHOSPH8 1 GO:0046456 icosanoid biosynthetic process 1/998 56/18722 0.953685559540671 0.974592348084135 MGST3 1 GO:0050433 regulation of catecholamine secretion 1/998 56/18722 0.953685559540671 0.974592348084135 SYT7 1 GO:0046330 positive regulation of JNK cascade 2/998 89/18722 0.954470577264379 0.975203695478928 APP/TLR3 2 GO:0045580 regulation of T cell differentiation 4/998 146/18722 0.955703918438789 0.976272776006441 CD46/GLI3/GATA3/PNP 4 GO:0010257 NADH dehydrogenase complex assembly 1/998 57/18722 0.956161816455833 0.976358467380384 NDUFB9 1 GO:0032981 mitochondrial respiratory chain complex I assembly 1/998 57/18722 0.956161816455833 0.976358467380384 NDUFB9 1 GO:0046031 ADP metabolic process 2/998 90/18722 0.956503153124148 0.976516027074927 APP/AK3 2 GO:0002275 myeloid cell activation involved in immune response 2/998 91/18722 0.958448691853977 0.978178029123519 SNX4/ANXA3 2 GO:0050432 catecholamine secretion 1/998 58/18722 0.958505802910538 0.978178029123519 SYT7 1 GO:0048525 negative regulation of viral process 2/998 92/18722 0.960310684930359 0.979782865742621 MPHOSPH8/HEXIM1 2 GO:0002366 leukocyte activation involved in immune response 9/998 275/18722 0.960453688349116 0.979782865742621 CD46/TFRC/HSPD1/SWAP70/EIF2AK4/RIF1/GATA3/SNX4/ANXA3 9 GO:0019369 arachidonic acid metabolic process 1/998 59/18722 0.960724577487011 0.979867751330276 CYP2J2 1 GO:0019217 regulation of fatty acid metabolic process 2/998 93/18722 0.962092499387499 0.980879699141209 ACADVL/PPARG 2 GO:0032088 negative regulation of NF-kappaB transcription factor activity 2/998 93/18722 0.962092499387499 0.980879699141209 BMP7/UFL1 2 GO:0022613 ribonucleoprotein complex biogenesis 17/998 463/18722 0.962774745460006 0.981265472661184 PRKDC/EIF3A/SF1/SRSF5/DDX17/RBM5/DICER1/HSP90AA1/SF3B1/DDX1/AGO2/DENR/SNRNP200/PRPF8/LSG1/LUC7L3/RPS21 17 GO:0006690 icosanoid metabolic process 3/998 123/18722 0.962846775798361 0.981265472661184 MGST3/ATP6V1B1/CYP2J2 3 GO:0007368 determination of left/right symmetry 3/998 124/18722 0.96434165412199 0.982310444958199 GALNT11/FOLR1/AHI1 3 GO:0009132 nucleoside diphosphate metabolic process 3/998 124/18722 0.96434165412199 0.982310444958199 APP/DLG1/AK3 3 GO:0042255 ribosome assembly 1/998 61/18722 0.964812863770474 0.982310444958199 PRKDC 1 GO:0043030 regulation of macrophage activation 1/998 61/18722 0.964812863770474 0.982310444958199 HSPD1 1 GO:0050994 regulation of lipid catabolic process 1/998 61/18722 0.964812863770474 0.982310444958199 IDH1 1 GO:0009116 nucleoside metabolic process 1/998 62/18722 0.966694690144037 0.983842685622226 PNP 1 GO:0045576 mast cell activation 1/998 62/18722 0.966694690144037 0.983842685622226 SNX4 1 GO:0031929 TOR signaling 3/998 126/18722 0.967163037609396 0.984127503285648 SLC38A9/GNA12/GATA3 3 GO:0016064 immunoglobulin mediated immune response 6/998 207/18722 0.967445811242253 0.98422341786746 CD46/TFRC/CD55/HSPD1/SWAP70/RIF1 6 GO:0016239 positive regulation of macroautophagy 1/998 63/18722 0.968475970917684 0.984738800614709 UVRAG 1 GO:0031343 positive regulation of cell killing 1/998 63/18722 0.968475970917684 0.984738800614709 CADM1 1 GO:0019216 regulation of lipid metabolic process 11/998 331/18722 0.968518241937662 0.984738800614709 ORMDL1/IDH1/VAV3/LPCAT3/SF1/ACADVL/MBTPS1/SORBS1/PPARG/PTK2/ACSL3 11 GO:0006260 DNA replication 8/998 260/18722 0.970064649798093 0.985834212488952 EGFR/ATRX/RBBP7/ANKRD17/PURA/WAPL/BOD1L1/PDS5A 8 GO:0006940 regulation of smooth muscle contraction 1/998 64/18722 0.970162073121669 0.985834212488952 ATP2B1 1 GO:0048247 lymphocyte chemotaxis 1/998 64/18722 0.970162073121669 0.985834212488952 PLEC 1 GO:0019724 B cell mediated immunity 6/998 210/18722 0.97056314285368 0.986033019127353 CD46/TFRC/CD55/HSPD1/SWAP70/RIF1 6 GO:0051250 negative regulation of lymphocyte activation 4/998 157/18722 0.970735437332809 0.986033019127353 DLG5/DLG1/GLI3/PAWR 4 GO:0006334 nucleosome assembly 3/998 129/18722 0.971002885251654 0.986049695990569 ATRX/SMARCA5/HP1BP3 3 GO:0007631 feeding behavior 2/998 99/18722 0.971273347185088 0.986049695990569 APP/EIF2AK4 2 GO:0006753 nucleoside phosphate metabolic process 18/998 497/18722 0.971318442152747 0.986049695990569 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/QPRT/CROT/SMPDL3A/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 18 GO:0061512 protein localization to cilium 1/998 65/18722 0.97175807757148 0.986304222978363 RABEP1 1 GO:0006956 complement activation 3/998 130/18722 0.972185500441167 0.98654625807645 CD46/CD55/CD59 3 GO:0042093 T-helper cell differentiation 1/998 66/18722 0.973268794116673 0.98745362885409 GATA3 1 GO:0045833 negative regulation of lipid metabolic process 2/998 102/18722 0.975019022486745 0.989037170468874 ORMDL1/ACADVL 2 GO:0071824 protein-DNA complex subunit organization 7/998 241/18722 0.975333896948114 0.989124463388483 ATRX/BPTF/SMARCA5/SETD2/HP1BP3/BDP1/SMARCC1 7 GO:0002377 immunoglobulin production 6/998 216/18722 0.975989729068632 0.989124463388483 TFRC/PRKDC/HSPD1/SWAP70/RIF1/YY1 6 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 1/998 68/18722 0.976052333916389 0.989124463388483 GATA3 1 GO:0009247 glycolipid biosynthetic process 1/998 68/18722 0.976052333916389 0.989124463388483 PGAP1 1 GO:0042267 natural killer cell mediated cytotoxicity 1/998 68/18722 0.976052333916389 0.989124463388483 CADM1 1 GO:0032147 activation of protein kinase activity 3/998 134/18722 0.976474094809897 0.989359838735198 DLG1/PRLR/TLR3 3 GO:0032006 regulation of TOR signaling 2/998 104/18722 0.977249015313885 0.989654471492173 SLC38A9/GNA12 2 GO:0002287 alpha-beta T cell activation involved in immune response 1/998 69/18722 0.977333548173462 0.989654471492173 GATA3 1 GO:0002293 alpha-beta T cell differentiation involved in immune response 1/998 69/18722 0.977333548173462 0.989654471492173 GATA3 1 GO:0044782 cilium organization 12/998 368/18722 0.978015034034041 0.990152509732738 GALNT11/LAMA5/YAP1/FNBP1L/DYNLL2/ATMIN/CDKL5/LIMK2/AHI1/PCM1/RP2/MAP4 12 GO:0007286 spermatid development 4/998 165/18722 0.97851010034458 0.990306287435999 SMARCA2/JAM3/QKI/TMF1 4 GO:0002548 monocyte chemotaxis 1/998 70/18722 0.978546281724252 0.990306287435999 ANO6 1 GO:0034754 cellular hormone metabolic process 3/998 137/18722 0.979269699705113 0.990846337627984 HSD17B1/PLEKHA1/ALDH1A3 3 GO:0002228 natural killer cell mediated immunity 1/998 71/18722 0.979694191376793 0.990888733965616 CADM1 1 GO:0045824 negative regulation of innate immune response 1/998 71/18722 0.979694191376793 0.990888733965616 PPARG 1 GO:0009117 nucleotide metabolic process 17/998 489/18722 0.979880967911219 0.990888733965616 APP/SLC26A2/ACSS1/DLG1/PARP1/NUDT4/TPST2/QPRT/CROT/VCP/ACSF2/ACSL3/FASN/AK3/FAR1/TECR/PNP 17 GO:0009451 RNA modification 4/998 167/18722 0.980124508283406 0.990943078572359 RBM47/ZC3H13/TARBP1/CMTR1 4 GO:0002274 myeloid leukocyte activation 6/998 223/18722 0.981144803519905 0.991591160912686 APP/ITGB8/HSPD1/TLR3/SNX4/ANXA3 6 GO:0006958 complement activation, classical pathway 2/998 108/18722 0.981145362435345 0.991591160912686 CD46/CD55 2 GO:0051937 catecholamine transport 1/998 73/18722 0.981809201193508 0.991878064905438 SYT7 1 GO:1904427 positive regulation of calcium ion transmembrane transport 1/998 73/18722 0.981809201193508 0.991878064905438 SLC9A1 1 GO:0046034 ATP metabolic process 8/998 277/18722 0.982417952945515 0.992301050943807 APP/PARP1/ATP6V1B1/VCP/HSPA1B/UQCRC1/NDUFB9/COX6A1 8 GO:0048515 spermatid differentiation 4/998 172/18722 0.983674078297638 0.993215853345742 SMARCA2/JAM3/QKI/TMF1 4 GO:2001259 positive regulation of cation channel activity 1/998 75/18722 0.98370411370443 0.993215853345742 ANK3 1 GO:0140029 exocytic process 1/998 76/18722 0.984576280515337 0.993904246049995 SNX4 1 GO:0001578 microtubule bundle formation 2/998 113/18722 0.985113377739718 0.994254193925975 CLIP1/CAPN6 2 GO:0003341 cilium movement 4/998 175/18722 0.985506185370401 0.99445840622707 ATP2B4/ASH1L/VPS13A/TMF1 4 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1/998 78/18722 0.986183201271369 0.994949274171559 GNAI1 1 GO:0051209 release of sequestered calcium ion into cytosol 2/998 115/18722 0.98646190542475 0.995038177786441 MCOLN3/DMD 2 GO:0001895 retina homeostasis 1/998 79/18722 0.986922804636053 0.995095790852924 SLC2A1 1 GO:0051279 regulation of release of sequestered calcium ion into cytosol 1/998 79/18722 0.986922804636053 0.995095790852924 DMD 1 GO:0051283 negative regulation of sequestering of calcium ion 2/998 116/18722 0.98709080651739 0.995095790852924 MCOLN3/DMD 2 GO:0051321 meiotic cell cycle 7/998 261/18722 0.987335449747958 0.995150267014303 CALR/RAD50/ATRX/TOP2B/RAD21/SUN1/GOLGA2 7 GO:0006399 tRNA metabolic process 4/998 179/18722 0.987647011904496 0.995202945304066 IARS2/DICER1/TARBP1/DDX1 4 GO:0051282 regulation of sequestering of calcium ion 2/998 118/18722 0.988264385517365 0.995202945304066 MCOLN3/DMD 2 GO:0006096 glycolytic process 1/998 81/18722 0.988285465912935 0.995202945304066 APP 1 GO:0002443 leukocyte mediated immunity 14/998 440/18722 0.988592863259779 0.995202945304066 CD46/TFRC/CADM1/CD55/HSPD1/TLR3/SWAP70/RIF1/DHX36/FZD5/DDX1/GATA3/SNX4/ANXA3 14 GO:0006261 DNA-dependent DNA replication 3/998 151/18722 0.988621851585232 0.995202945304066 ATRX/PURA/BOD1L1 3 GO:0031497 chromatin assembly 3/998 151/18722 0.988621851585232 0.995202945304066 ATRX/SMARCA5/HP1BP3 3 GO:0001910 regulation of leukocyte mediated cytotoxicity 1/998 82/18722 0.988912637471268 0.995202945304066 CADM1 1 GO:0006757 ATP generation from ADP 1/998 82/18722 0.988912637471268 0.995202945304066 APP 1 GO:0042180 cellular ketone metabolic process 5/998 211/18722 0.989186299282521 0.995286503864722 ATP2B4/HSD17B1/ACADVL/CLN3/PPARG 5 GO:0120254 olefinic compound metabolic process 3/998 153/18722 0.989568797062104 0.995479516273843 HSD17B1/CYP2J2/ALDH1A3 3 GO:0002455 humoral immune response mediated by circulating immunoglobulin 2/998 121/18722 0.989832125842091 0.995552596613669 CD46/CD55 2 GO:0002695 negative regulation of leukocyte activation 4/998 187/18722 0.991059414676376 0.99659499307114 DLG5/DLG1/GLI3/PAWR 4 GO:0008033 tRNA processing 2/998 127/18722 0.992378461780146 0.997729241084949 TARBP1/DDX1 2 GO:0006400 tRNA modification 1/998 90/18722 0.992861505796327 0.998022703458341 TARBP1 1 GO:0006323 DNA packaging 4/998 199/18722 0.99454157205209 0.999352865782168 ATRX/SMARCA5/HP1BP3/WAPL 4 GO:0008277 regulation of G protein-coupled receptor signaling pathway 2/998 134/18722 0.994567609769038 0.999352865782168 MET/ATP2B4 2 GO:0065004 protein-DNA complex assembly 4/998 201/18722 0.994977181775111 0.999355710907577 ATRX/SMARCA5/HP1BP3/BDP1 4 GO:1990868 response to chemokine 1/998 97/18722 0.995144673627369 0.999355710907577 DOCK8 1 GO:1990869 cellular response to chemokine 1/998 97/18722 0.995144673627369 0.999355710907577 DOCK8 1 GO:0006165 nucleoside diphosphate phosphorylation 1/998 99/18722 0.995651080646274 0.999513713599326 APP 1 GO:0006641 triglyceride metabolic process 1/998 100/18722 0.995884137700187 0.999513713599326 SEL1L 1 GO:0006910 phagocytosis, recognition 1/998 100/18722 0.995884137700187 0.999513713599326 COLEC12 1 GO:0046939 nucleotide phosphorylation 1/998 101/18722 0.996104717153264 0.999513713599326 APP 1 GO:0002449 lymphocyte mediated immunity 9/998 350/18722 0.996259215776842 0.999513713599326 CD46/TFRC/CADM1/CD55/HSPD1/SWAP70/RIF1/FZD5/GATA3 9 GO:0050866 negative regulation of cell activation 4/998 210/18722 0.996555957320911 0.999619337785298 DLG5/DLG1/GLI3/PAWR 4 GO:0006090 pyruvate metabolic process 1/998 106/18722 0.997042600507738 0.999915370198021 APP 1 GO:0002832 negative regulation of response to biotic stimulus 1/998 108/18722 0.997351200150106 0.999999999717688 PPARG 1 GO:0006805 xenobiotic metabolic process 1/998 111/18722 0.997754836601872 0.999999999717688 CYP2J2 1 GO:0001906 cell killing 3/998 188/18722 0.997810352875291 0.999999999717688 CADM1/CD55/CD59 3 GO:0034470 ncRNA processing 10/998 395/18722 0.997985279604706 0.999999999717688 LIN28B/PRKDC/DDX17/DICER1/TARBP1/DDX1/AGO2/INTS6/RPS21/HNRNPA2B1 10 GO:0034660 ncRNA metabolic process 13/998 485/18722 0.998587917128334 0.999999999717688 KCNQ1OT1/IARS2/LIN28B/PRKDC/SND1/DDX17/DICER1/TARBP1/DDX1/AGO2/INTS6/RPS21/HNRNPA2B1 13 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/998 356/18722 0.998859655579445 0.999999999717688 CD46/TFRC/CD55/HSPD1/SWAP70/RIF1/FZD5/GATA3 8 GO:0001909 leukocyte mediated cytotoxicity 1/998 124/18722 0.998903592724949 0.999999999717688 CADM1 1 GO:0006639 acylglycerol metabolic process 1/998 128/18722 0.999120674514654 0.999999999717688 SEL1L 1 GO:0006638 neutral lipid metabolic process 1/998 129/18722 0.999167870751847 0.999999999717688 SEL1L 1 GO:0006364 rRNA processing 3/998 225/18722 0.999606569666064 0.999999999717688 PRKDC/DDX17/RPS21 3 GO:0016072 rRNA metabolic process 3/998 236/18722 0.999766261915754 0.999999999717688 PRKDC/DDX17/RPS21 3 GO:0006959 humoral immune response 5/998 317/18722 0.999861762154971 0.999999999717688 CD46/CD55/CD59/GATA3/BCL2 5 GO:0042254 ribosome biogenesis 4/998 299/18722 0.999933407837552 0.999999999717688 PRKDC/DDX17/LSG1/RPS21 4 GO:0042742 defense response to bacterium 5/998 350/18722 0.999967881442616 0.999999999717688 COLEC12/TLR3/ANKRD17/TMF1/ANXA3 5 GO:0007608 sensory perception of smell 2/998 456/18722 0.999999999717688 0.999999999717688 NAV2/B3GNT2 2