category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	69/1271	238/9376	2.13867199121978	CFD/RPL3/RPL13A/RPL18A/RPL12/RPL10/RPS20/RPS27/RPL6/RPS4X/RPL37A/RPL27A/RPLP0/RPS2/RPS9/JUN/RPS11/RPL15/RPL23A/RPS29/RPL29/FOS/RPL7A/RPS16/RPL5/RPL10A/RPS5/RPL31/RPL9/RPL37/RPSA/C1S/RPS23/RPS6/NFKBIA/RPL7/RPS26/RPS13/ACE2/RPL14/RPL17/RPL4/RPL30/CXCL8/PLCG2/RPS17/SYK/RPL22/PIK3CD/AGTR1/MAP3K7/C3AR1/C5AR1/NFKB1/RPS21/F13A1/C2/MAPK1/MAPK3/RELA/CYBB/MAVS/ACE/TRAF3/TYK2/NRP1/C6/NLRP3/CASP1	7.04601305738654
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	32/1271	93/9376	2.53827737028671	CD247/JUN/IL2RB/FOS/NFKBIA/RUNX3/GATA3/NFATC3/NFATC1/ZAP70/CD3E/HLA-DRB5/DLL1/PPP3R1/NOTCH1/HLA-DQB2/DLL3/RBPJ/NFKB1/CD3D/MAPK1/IFNG/MAPK3/MAML1/RELA/PRKCQ/JAG2/TYK2/JAK3/HLA-DOB/STAT5A/IL4R	5.90355826815053
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	34/1271	105/9376	2.38870031096624	CARD11/GADD45A/NFKBIA/CXCL8/ICAM1/PLCG2/CXCL1/SYK/TRAF5/ZAP70/TAB3/BCL10/MAP3K7/CCL4L2/TRAF1/ATM/RIPK1/LTB/GADD45B/RELB/TICAM1/NFKB1/NFKB2/CXCL12/EDA/CD14/RELA/IL1R1/PRKCQ/TAB1/PIAS4/VCAM1/TRAF3/TRADD	5.66659006215636
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	27/1271	75/9376	2.65567269866247	PIK3CD/CDKN2A/ERCC1/SLC31A1/MDM2/ATM/CDKN1A/CASP3/TOP2B/GSTO2/GSTA4/GSTM4/ATP7A/BAX/FASLG/CASP8/MAPK1/MAPK3/BRCA1/APAF1/AKT2/PMAIP1/AKT1/GSTM5/TP53/GSTM2/MSH6	5.7006214275171
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	57/1271	224/9376	1.8771496009891	EGR1/JUN/IL2RB/FOS/SLC25A6/NFKBIA/ICAM1/MSX1/NFATC3/NFATC1/EP300/CD3E/PIK3CD/CDKN2A/BUB3/MSX2/HLA-DRB5/PRKACA/E2F3/ATM/CDKN1A/MAP3K1/TGFB1/PPP3R1/KAT5/CDC26/CRTC2/ITGAL/HLA-DQB2/RELB/NFKB1/NFKB2/ELK4/BAX/CD3D/ADCY3/SRF/TRRAP/MAPK1/MAPK3/MYC/RELA/IL1R1/ITGB2/MAP3K3/AKT2/IL15RA/CREBBP/JAK3/AKT1/NRP1/ADCY4/TP53/HLA-DOB/STAT5A/FOSL1/TGFB2	5.26164541590742
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	53/1271	205/9376	1.90719042044866	CD44/CD247/JUN/VIM/GADD45A/NFKBIA/RUNX3/ENTPD1/ICAM1/PLCG2/SYK/TRAF5/CD3E/PIK3CD/HLA-DRB5/MAP3K7/E2F3/MDM2/CDKN1A/RIPK1/CASP3/BCL2L11/PSMD11/GADD45B/ITGAL/HLA-DQB2/PSMC2/RBPJ/RELB/NFKB1/NFKB2/BAX/CD3D/CASP8/MYC/RELA/PSMD12/APAF1/NCOR2/TAB1/AKT2/MAVS/SAP30L/TRAF3/TYK2/JAK3/AKT1/SKP2/SNW1/TRADD/TP53/HLA-DOB/PSMD13	5.2005460135684
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/1271	101/9376	2.33722569739271	COL3A1/COL1A2/EGR1/JUN/FN1/COL1A1/CXCL8/ICAM1/PLCG2/COL4A1/NFATC1/PIK3CD/DIAPH1/AGTR1/COL4A2/CASP3/TGFB1/NFKB1/BAX/MAPK1/PIM1/MAPK3/RELA/CYBB/PLCB2/AKT2/AGT/VCAM1/PLCB4/AKT1/STAT5A/TGFB2	5.35045043758773
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	29/1271	93/9376	2.30031386682233	FN1/LAMA2/GADD45A/NFKBIA/ITGAV/LAMB1/ITGB1/COL4A1/TRAF5/PIK3CD/TRAF1/E2F3/CDKN1A/COL4A2/CASP3/GADD45B/LAMC2/NFKB1/BAX/MYC/RELA/APAF1/AKT2/RXRB/TRAF3/LAMC1/AKT1/SKP2/TP53	4.9903085281941
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	25/1271	77/9376	2.39508721019343	GADD45A/NFKBIA/PIK3CD/CDKN2A/BCR/E2F3/MDM2/CDKN1A/TGFB1/GADD45B/NFKB1/BAX/MAPK1/MAPK3/CRKL/MYC/CRK/RELA/AKT2/SOS2/AKT1/TP53/CTBP1/STAT5A/TGFB2	4.86755087994956
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	30/1271	103/9376	2.14860250700847	COL3A1/COL1A2/FN1/LAMA2/COL1A1/LAMB1/CXCL8/RAB7B/CXCL1/COL4A1/SERPINB9/PIK3CD/PRKACA/COL4A2/CASP3/TGFB1/LAMC2/NFKB1/ARG2/CD14/IFNG/RELA/IL1R1/ITGB2/PLCB2/LAMC1/RAB5A/PLCB4/TGFB2/ITGAM	4.6415191457452
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/1271	109/9376	2.09800850302081	CD247/JUN/IL2RB/FOS/RORA/NFKBIA/GATA3/NFATC3/NFATC1/ZAP70/CD3E/HLA-DRB5/TGFB1/PPP3R1/HLA-DQB2/IL21R/NFKB1/CD3D/RARA/MAPK1/IFNG/MAPK3/RELA/IL1R1/PRKCQ/RXRB/TYK2/JAK3/HLA-DOB/STAT5A/IL4R	4.56595129610399
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/1271	62/9376	2.49861678637598	DTX4/EP300/NUMB/DLL1/NOTCH1/DLL3/RBPJ/TLE4/HEY2/DVL3/MAML1/MFNG/NCOR2/NOTCH4/JAG2/CREBBP/NRARP/SNW1/TLE3/CTBP1/PSEN1	4.68813624774442
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	36/1271	137/9376	1.93844722530107	ACTG1/JUN/FOS/PRF1/GADD45A/NFKBIA/MCL1/TUBA4A/PIK3CD/TRAF1/ATM/RIPK1/CASP3/BCL2L11/GADD45B/NFKB1/LMNB1/BAX/FASLG/CASP8/MAPK1/MAPK3/RELA/APAF1/LMNB2/AKT2/TNFRSF10B/CAPN1/PMAIP1/AKT1/TRADD/TP53/ENDOG/IL3RA/ITPR2/CTSS	4.38166891414282
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1271	87/9376	2.11978982971142	JUN/FOS/GADD45A/PIK3CD/CDKN1A/TCF7/CASP3/BCL2L11/TGFB1/GADD45B/BAX/RALB/MAPK1/MAPK3/MYC/AKT2/SOS2/GSK3B/RALGDS/PMAIP1/AKT1/TP53/MSH6/AXIN1/TGFB2	4.15521564556708
Genetic Information Processing	Translation	hsa03010	Ribosome	50/1271	222/9376	1.6614568935576	RPL3/RPL13A/RPL18A/RPL12/RPL10/RPS20/RPS27/RPL6/RPS4X/RPL37A/RPL27A/RPLP0/RPS2/RPS9/RPS11/RPL15/RPL23A/RPS29/RPL29/RPL7A/RACK1/RPS16/RPL5/RPL10A/RPS5/RPL31/RPL9/RPL37/RPSA/RPS23/RPS6/RPL7/RPS26/RPS13/RPL14/RPL17/RPL4/RPL30/RPS17/MRPL1/RPL22/MRPS24/RPS21/MRPS7/MRPS9/MRPL11/MRPL10/MRPL30/MRPS22/MRPL44	3.94961245727761
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	24/1271	83/9376	2.13307044069275	PRDX5/SOD2/GNPAT/ACSL4/ACOT8/PEX1/ACOX3/MPV17L2/ACSL5/PEX16/PEX13/IDH1/HMGCL/HSD17B4/ABCD4/PECR/EPHX2/IDH2/PEX10/PEX11G/FAR2/ABCD1/AMACR/PAOX	4.10581986307063
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	39/1271	163/9376	1.76501764226033	JUN/FOS/NFKBIA/CXCL8/PTK2B/NFATC3/NFATC1/EP300/PIK3CD/YWHAB/MAP3K7/E2F3/CDKN1A/MAP3K1/CASP3/TGFB1/DDB1/TICAM1/NFKB1/BAX/FASLG/CASP8/MAPK1/MAPK3/MYC/RELA/APAF1/TAB1/AKT2/MAVS/CREBBP/SOS2/TRAF3/TYK2/JAK3/AKT1/TP53/STAT5A/TGFB2	3.90163484425683
Organismal Systems	Immune system	hsa04611	Platelet activation	32/1271	126/9376	1.87349043997352	COL3A1/COL1A2/ACTG1/COL1A1/ITGB1/PLCG2/SYK/GP1BB/PIK3CD/PIK3R6/FYN/ARHGEF1/PRKACA/ARHGAP35/GUCY1A2/RASGRP1/PIK3CG/ADCY3/PIK3R5/MAPK1/MAPK3/PPP1R12A/PLCB2/AKT2/P2RY1/ROCK1/PLCB4/AKT1/ADCY4/PLA2G4A/PRKCI/ITPR2	3.90889915444194
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	21/1271	70/9376	2.21306058221873	JUN/PAK3/EP300/PIK3CD/CDKN1A/TGFB1/PRCC/MAPK1/MAPK3/CRKL/CRK/VHL/AKT2/CREBBP/GAB1/SOS2/AKT1/FH/FLCN/PDGFB/TGFB2	4.03396281498212
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	68/1271	333/9376	1.50638758349223	COL6A1/COL6A3/COL1A2/COL6A2/FN1/THBS2/TNXB/LAMA2/COL1A1/ITGAV/LAMB1/ITGB1/PATJ/SPP1/COL4A1/EP300/PIK3CD/PPP2R5C/RBL2/OASL/PRKACA/MDM2/ATM/CDKN1A/TCF7/COL4A2/CASP3/ATP6V0E2/NOTCH1/RBPJ/ITGB7/LAMC2/TICAM1/NFKB1/BAX/TSC2/FASLG/PDGFRB/HEY2/CASP8/MAPK1/MAPK3/DVL3/MAML1/RELA/UBR4/MFNG/PPP2R5D/NOTCH4/AKT2/FZD10/ATP6V1E2/TCIRG1/CREBBP/SOS2/TRAF3/GSK3B/TYK2/LAMC1/HES6/TADA3/AKT1/TRADD/TP53/PRKCI/LLGL2/AXIN1/PSEN1	3.72589664497604
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/1271	56/9376	2.37113633809149	EEF1A1/EEF1G/NFKBIA/CXCL8/CXCL1/RAB1B/CASP3/NAIP/CR1/NFKB1/NFKB2/CASP8/CD14/RELA/APAF1/ITGB2/CASP1/ITGAM	4.07519694408127
NA	NA	hsa04518	Integrin signaling	37/1271	154/9376	1.77236453554314	COL6A1/COL6A3/COL1A2/COL6A2/ACTG1/FN1/THBS2/TNXB/LAMA2/COL1A1/ITGAV/LAMB1/ITGB1/ICAM1/ITGAX/SPP1/COL4A1/PIK3CD/PARVG/COL4A2/TGFB1/ITGAL/ITGB7/LAMC2/PDGFRB/ARHGEF6/FLNA/ICAM3/ITGB2/AKT2/LIMS1/VCAM1/GSK3B/LAMC1/AKT1/PDGFB/ITGAM	3.826943315667
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	34/1271	138/9376	1.81748936703953	ACTG1/JUN/FOS/FN1/NFKBIA/FYB1/ITGB1/CXCL8/PTK2B/NFATC3/NFATC1/ZAP70/PIK3CD/ARHGEF1/WIPF2/MAP3K7/VAV1/WAS/LIMK1/TICAM1/NFKB1/MAPK1/MAPK3/CRKL/CRK/RELA/PKN1/TAB1/AKT2/GSK3B/ROCK1/AKT1/NLRP3/CASP1	3.83102142423466
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	36/1271	149/9376	1.78233067024327	CXCL8/PLCG2/PTK2B/SYK/DNM2/DGKZ/PIK3CD/PIK3R6/DGKI/AGTR1/FYN/CYTH4/CYTH1/AGPAT3/DGKQ/PIK3CG/TSC2/ADCY3/PDGFRB/RALB/PIK3R5/MAPK1/DNM3/MAPK3/PLCB2/AKT2/AGT/GAB1/SOS2/RALGDS/PLCB4/AKT1/ADCY4/AGPAT5/PLA2G4A/PDGFB	3.8118441361506
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1271	122/9376	1.87445021991204	CD247/JUN/FOS/CARD11/PAK3/NFKBIA/NFATC3/NFATC1/ZAP70/CD3E/PIK3CD/PPP2R5C/FYN/BCL10/MAP3K7/VAV1/PPP3R1/TEC1/RASGRP1/NFKB1/CD3D/MAPK1/IFNG/MAPK3/RELA/PRKCQ/PPP2R5D/AKT2/SOS2/GSK3B/AKT1	3.8497467671163
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	31/1271	122/9376	1.87445021991204	ACTG1/ITGAV/PLCG2/FXYD2/EP300/PIK3CD/PRKACA/PFKP/MDM2/NOTCH1/MED1/TSC2/MED24/MAPK1/MAPK3/MYC/MED12/HDAC3/THRB/PFKL/NOTCH4/PLCB2/AKT2/MED13/RXRB/CREBBP/GSK3B/PLCB4/AKT1/ATP1B1/TP53	3.8497467671163
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	44/1271	196/9376	1.65603172819088	JUN/FOS/MAP1LC3B/CALM1/GNG4/NFKBIA/CXCL8/ICAM1/PLCG2/CXCL1/SYK/NFATC3/NFATC1/EP300/CLEC2B/PIK3CD/PIK3R6/E2F3/CDKN1A/TCF7/CASP3/GNGT2/PPP3R1/PIK3CG/TICAM1/NFKB1/BAX/CASP8/PIK3R5/MAPK1/MAPK3/MYC/RELA/AKT2/CREBBP/TRAF3/GSK3B/TYK2/AKT1/BECN1/TRADD/TP53/PDGFB/ITPR2	3.67547474514596
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	44/1271	200/9376	1.62291109362707	ACTG1/JUN/FOS/EZR/PAK3/NFKBIA/ITGB1/CXCL8/TUBA4A/GAPDH/TUBB4B/TAB3/CYFIP2/TUBB3/BAIAP2L1/FYN/ARHGEF1/WIPF2/CYTH4/MAP3K7/NCKAP1L/CYTH1/RIPK1/CASP3/NAIP/MYO1C/MYO1F/MYO1G/NFKB1/BAX/FASLG/CASP8/MAPK1/TUBB2A/MAPK3/RELA/IL1R1/TAB1/TNFRSF10B/ROCK1/SEC24A/TRADD/NLRP3/CASP1	3.52611331542288
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	53/1271	253/9376	1.54535192170741	CD44/ACTG1/JUN/MAP1LC3B/NFKBIA/ITGB1/CXCL8/PLCG2/TRAF5/PIK3CD/TAB3/DIAPH1/BCL10/CYTH4/MAP3K7/RRAGB/MDM2/ATM/CYTH1/RIPK1/RPTOR/NAIP/MYL5/FNBP1/NFKB1/ATG16L1/TECPR1/BAX/MAPK1/CD14/CUL1/MAPK3/CRKL/CRK/RELA/IL1R1/PRKCQ/TAB1/PLCB2/AKT2/CAPN1/GSK3B/ROCK1/PLCB4/AKT1/BECN1/TRADD/TP53/NLRP3/NOD1/CASP1/ITPR2/TNIP1	3.48217164582091
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	52/1271	248/9376	1.54676277251846	ACTG1/JUN/FOS/PAK3/NFKBIA/CXCL8/RAB7B/TUBA4A/GAPDH/TUBB4B/DNM2/PIK3CD/TAB3/CYFIP2/TUBB3/CYTH4/MAP3K7/NCKAP1L/VPS39/CYTH1/TCF7/RIPK1/CASP3/AHNAK2/NAIP/DYNC1LI2/MYL5/DCTN5/PIK3CG/NFKB1/BAX/CASP8/MAPK1/TUBB2A/CD14/GCC2/FLNA/MAPK3/MYC/RELA/PKN1/TAB1/AKT2/TNFRSF10B/RAB5A/AKT1/EXOC7/TRADD/KLC4/NLRP3/NOD1/CASP1	3.45556340138793
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1271	37/9376	2.59187275394986	GADD45A/CDKN1A/TCF7/GADD45B/BAX/TPR/MAPK1/MAPK3/MYC/PPARG/RXRB/PAX8/TP53	3.84185462974717
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	24/1271	91/9376	1.94554776458789	JUN/FOS/CARD11/NFKBIA/INPP5D/PLCG2/SYK/NFATC3/NFATC1/PIK3CD/BANK1/BCL10/VAV1/PPP3R1/CD22/NFKB1/MAPK1/MAPK3/RELA/AKT2/SOS2/GSK3B/AKT1/LILRB4	3.5891790014513
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	36/1271	157/9376	1.69151127303342	PBX1/ITGAV/RAB7B/DUSP16/NFATC3/NFATC1/PECAM1/DNMT3A/STAB1/PPARD/VPS39/LRP1/CASP3/HAVCR2/TGFB1/SLC16A1/LIPA/ARG2/PLA2G6/CX3CR1/TMEM30A/MAPK1/MAPK3/CRKL/CD24/CRK/EPOR/PPARG/ATP11C/PLA2G15/RAB5A/CPT1A/CAMK2D/CASP1/SIRPA/P2RY6	3.46010347773975
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	25/1271	98/9376	1.88185423658055	CALM1/INPP5D/PIP4K2A/PLCG2/SACM1L/PIKFYVE/INPP4A/DGKZ/PIK3CD/DGKI/CDS2/MTMR4/OCRL/IP6K1/DGKQ/PI4K2A/PI4KB/IPPK/PPIP5K1/PI4K2B/IP6K2/PLCB2/PLCB4/INPP1/ITPR2	3.4750780504568
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/1271	142/9376	1.71434270453563	JUN/FOS/NFKBIA/SOCS3/PLCG2/SYK/NFATC1/PIK3CD/FYN/FOSB/MAP3K7/TGFB1/PPP3R1/TEC1/RELB/NFKB1/NFKB2/MAPK1/IFNG/MAPK3/RELA/IL1R1/PPARG/TAB1/AKT2/TYK2/AKT1/LILRB4/ITPR2/SIRPA/FOSL1/TGFB2/TMEM64	3.39654798640685
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1271	78/9376	1.98608000968347	JUN/FOS/CALM1/C1S/ITGB1/CXCL8/IRF8/CASP3/TICAM1/NFKB1/C2/MAPK1/CD14/MAPK3/RELA/ITGB2/C4BPA/NLRP3/NOD1/CASP1/ITGAM	3.46295293392621
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/1271	78/9376	1.98608000968347	EEF1A1/JUN/FOS/NFKBIA/ITGB1/HLA-DRB5/MAP3K7/TGFB1/CR1/HLA-DQB2/NFKB1/MAPK1/IFNG/MAPK3/RELA/ITGB2/CYBB/TAB1/HLA-DOB/TGFB2/ITGAM	3.46295293392621
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	20/1271	73/9376	2.02105989243719	GADD45A/PLCG2/EML4/PIK3CD/CDKN2A/E2F3/CDKN1A/RASSF5/GADD45B/RASSF1/BAX/MAPK1/MAPK3/AKT2/RXRB/SOS2/JAK3/AKT1/TP53/STAT5A	3.46803155800081
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1271	68/9376	2.06118387559587	DUSP6/PIK3CD/PPARD/TCF7/NFKB1/JUP/RARA/MAPK1/CD14/PIM1/MAPK3/MYC/RELA/AKT2/SOS2/AKT1/PER2/STAT5A/ITGAM	3.47775365168771
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	23/1271	90/9376	1.88519975522336	CD247/JUN/FOS/NFKBIA/NFATC3/NFATC1/EML4/ZAP70/CD3E/PIK3CD/PPP3R1/RASGRP1/TICAM1/NFKB1/CD3D/MAPK1/IFNG/MAPK3/RELA/PRKCQ/MAP3K3/AKT2/AKT1	3.34141258586203
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	43/1271	203/9376	1.56258793161585	COL6A1/COL6A3/COL1A2/COL6A2/ACTG1/JUN/FN1/PAK3/THBS2/TNXB/LAMA2/COL1A1/ITGAV/LAMB1/ITGB1/SPP1/COL4A1/PIK3CD/CAV1/DIAPH1/FYN/PARVG/VAV1/COL4A2/ARHGAP35/MYL5/ITGB7/LAMC2/PDGFRB/MAPK1/FLNA/MAPK3/CRKL/CRK/PPP1R12A/AKT2/SOS2/GSK3B/LAMC1/PPP1R12C/ROCK1/AKT1/PDGFB	3.20896246878044
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	47/1271	227/9376	1.5273692711348	CALM1/GNG4/NFKBIA/ITGAV/CXCL8/PTK2B/NFATC3/NFATC1/TRAF5/PIK3CD/CDKN2A/ARHGEF1/PRKACA/CCL4L2/E2F3/MDM2/CDKN1A/RIPK1/CASP3/GNGT2/PPP3R1/NFKB1/CXCL12/BAX/TSC2/FASLG/IL10RA/ADCY3/CASP8/MAPK1/MAPK3/CRKL/MYC/CRK/RELA/IL1R1/PLCB2/AKT2/SOS2/GSK3B/ROCK1/PLCB4/AKT1/ADCY4/TRADD/TP53/ITPR2	3.18509829293279
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	27/1271	112/9376	1.77835225356862	LAMA2/NFKBIA/LAMB1/ITGB1/PIK3R6/HLA-DRB5/MAP3K7/CASP3/TGFB1/HLA-DQB2/PIK3CG/LAMC2/NFKB1/IL10RA/CASP8/PIK3R5/MAPK1/IFNG/MAPK3/RELA/TAB1/AKT2/TYK2/LAMC1/AKT1/HLA-DOB/TGFB2	3.2814653985679
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/1271	41/9376	2.33900711941817	DAPK2/CXCL8/TYMP/CDKN2A/E2F3/MDM2/CDKN1A/RASSF1/MAPK1/MAPK3/MYC/DAPK1/TP53	3.40251115141029
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	25/1271	105/9376	1.75639728747518	JUN/CALM1/NFKBIA/PLCG2/SYK/NFATC3/NFATC1/PIK3CD/BCL10/MDM2/PPP3R1/RELB/NFKB1/NFKB2/CASP8/MAPK1/MAPK3/RELA/KSR1/AKT2/LSP1/AKT1/NLRP3/CASP1/ITPR2	3.08647828361656
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	20/1271	78/9376	1.89150477112712	INPP5D/PIP4K2A/PLCG2/SACM1L/PIKFYVE/INPP4A/PIK3CD/MTMR4/OCRL/IP6K1/PIK3CG/PI4K2A/PI4KB/IPPK/PPIP5K1/PI4K2B/IP6K2/PLCB2/PLCB4/INPP1	3.13082004752825
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	44/1271	216/9376	1.5026954570621	JUN/FOS/CALM1/NFKBIA/CXCL8/ICAM1/CXCL1/SOD2/NFATC3/NFATC1/PIK3CD/ARHGEF1/MAP3K7/VAV1/CASP3/ABCG1/PPP3R1/TICAM1/NFKB1/BAX/FASLG/CASP8/MAPK1/CD14/MAPK3/RELA/APAF1/PPARG/CYBB/TAB1/MIB2/PLCB2/AKT2/TNFRSF10B/RXRB/VCAM1/TRAF3/GSK3B/PLCB4/AKT1/CAMK2D/TP53/NLRP3/CASP1	2.9598247885812
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	38/1271	181/9376	1.54873484575159	CALM1/ITGAX/SYK/EP300/HLA-DRB5/BCL10/CASP3/TGFB1/PPP3R1/CR1/HLA-DQB2/NFKB1/MRC1/BAX/IL10RA/CASP8/MAPK1/CD14/IFNG/MAPK3/RELA/RFXANK/APAF1/ITGB2/KSR1/AKT2/TCIRG1/CREBBP/LSP1/RAB5A/TLR1/AKT1/TRADD/CAMK2D/HLA-DOB/CTSS/TGFB2/ITGAM	2.95194229896564
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	27/1271	119/9376	1.67374329747635	JUN/FOS/NFKBIA/SOCS3/ICAM1/CXCL1/TRAF5/PIK3CD/TAB3/MAP3K7/TRAF1/RIPK1/CASP3/DNM1L/NFKB1/CASP8/MAPK1/MAPK3/RELA/TAB1/AKT2/VCAM1/TRAF3/AKT1/TRADD/RHBDF2/PGAM5	2.92896856382749
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/1271	108/9376	1.7076084739342	EEF1A1/NUP210L/NCBP1/NUP205/EIF4A3/TNPO3/KPNA2/NUP43/TNPO2/THOC1/TPR/PHAX/SEC13/IPO8/SEH1L/NUP50/IPO5/NUP62/XPO5/NUP153/IPO13/NCBP2/NUP107/KPNB1/RAE1	2.92882750367723
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1271	30/9376	2.45895620246525	FOLR2/GART/DHFR2/NFKB1/ABCC4/TYMS/RELA/MTHFR/SLC19A1/SHMT1	3.16936237253986
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	43/1271	214/9376	1.48226799120569	CD247/JUN/FOS/CALM1/PAK3/GNG4/NFKBIA/PLCG2/PTK2B/NFATC3/NFATC1/TRAF5/CD3E/PIK3CD/MAP3K7/DCAF1/AP1B1/ATM/RIPK1/CASP3/GNGT2/PPP3R1/CUL4B/DDB1/LIMK1/NFKB1/BAX/CD3D/FASLG/CASP8/MAPK1/CUL1/MAPK3/CRKL/CRK/RELA/TRIM5/TAB1/AKT2/AKT1/TRADD/APOBEC3H/ITPR2	2.82606459989108
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	37/1271	178/9376	1.53339403636878	SFRP2/JUN/CTNND2/SFRP4/NFATC3/NFATC1/SERPINF1/EP300/CCDC88C/RSPO3/CHD8/MAP3K7/PPARD/PRKACA/TCF7/PPP3R1/APCDD1/TLE4/RUVBL1/CACYBP/CUL1/MYC/DVL3/PLCB2/FZD10/PRICKLE3/CREBBP/GSK3B/PLCB4/ANKRD6/CAMK2D/TLE3/TP53/CTBP1/AXIN1/FOSL1/PSEN1	2.84507263303531
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1271	173/9376	1.53507092408235	ACTG1/SLC25A6/NFKBIA/SOCS3/CXCL8/ICAM1/EP300/PIK3CD/HLA-DRB5/CASP3/HNRNPUL1/KPNA2/HLA-DQB2/TICAM1/NFKB1/BAX/FASLG/CASP8/MAPK1/IFNG/MAPK3/RELA/APAF1/AKT2/MAVS/TNFRSF10B/CREBBP/TRAF3/TYK2/AKT1/TRADD/HLA-DOB/BCL2L2-PABPN1/NLRP3/CASP1/RAE1	2.81288253370091
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1271	76/9376	1.84421715184894	CALM1/GADD45A/PLCG2/PIK3CD/CDKN2A/E2F3/MDM2/CDKN1A/GADD45B/BAX/PDGFRB/MAPK1/MAPK3/AKT2/SOS2/AKT1/CAMK2D/TP53/PDGFB	2.92618242231367
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	31/1271	144/9376	1.58807588075881	NFKBIA/CXCL8/CXCL1/TAB3/ALDH3A2/MAP3K7/TCF7/RIPK1/LPIN2/CASP3/C3AR1/ACACA/ACOX3/C5AR1/TICAM1/NFKB1/FASLG/SREBF1/C2/CASP8/CD14/IL17RC/RELA/TAB1/AKT2/TRAF3/GSK3B/AKT1/PPARA/CPT1A/TRADD	2.81610354776505
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1271	110/9376	1.6765610471354	LDHA/RPS6/PLCG2/GAPDH/EP300/PIK3CD/PFKP/CDKN1A/ALDOA/NFKB1/EIF4E2/MAPK1/IFNG/MAPK3/RELA/VHL/MKNK2/PFKL/CYBB/AKT2/CREBBP/ENO2/AKT1/CAMK2D/PDHA1	2.82643555916096
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	25/1271	110/9376	1.6765610471354	THSD4/FMOD/BMP8B/EP300/TGFB1/ZFYVE9/ID4/SMURF2/SMAD5/BMPR1A/MAPK1/IFNG/CUL1/MAPK3/MYC/RGMA/NBL1/GDF7/CREBBP/ID2/ROCK1/HAMP/SMAD1/BMPR1B/TGFB2	2.82643555916096
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1271	99/9376	1.71381795929396	JUN/FOS/PIK3CD/CDKN2A/PRKACA/E2F3/MDM2/CDKN1A/DLL1/NOTCH1/DLL3/BAX/MED1/ADCY3/MAPK1/MAPK3/NOTCH4/AKT2/JAG2/SOS2/AKT1/ADCY4/TP53	2.82737356562111
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1271	31/9376	2.37963503464379	PFKP/PGM1/GLYCTK/ALDOA/RPE/IDNK/PFKL/PRPS2/SHPK/GPI	3.04675345516076
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1271	77/9376	1.820266279747	GADD45A/PIK3CD/CDKN2A/E2F3/CDKN1A/TGFB1/GADD45B/NFKB1/BAX/RALB/ARHGEF6/MAPK1/MAPK3/RELA/AKT2/RALGDS/AKT1/TP53/TGFB2	2.86196290999034
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	33/1271	157/9376	1.55055200028064	CALM1/SLC25A6/GADD45A/KIR2DL4/CXCL8/NFATC3/NFATC1/PIK3CD/CDKN2A/RBL2/E2F3/MDM2/ATM/CDKN1A/RASSF5/TGFB1/PPP3R1/GADD45B/RAD1/NFKB1/TSC2/LIN54/MAPK1/MAPK3/MYC/RELA/ZFP36L2/AKT2/CAPN1/AKT1/TP53/ITPR2/TGFB2	2.75478790460085
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	39/1271	193/9376	1.49066256833386	GNG4/NFKBIA/CXCL8/PLCG2/DOCK2/CXCL1/PTK2B/PIK3CD/PIK3R6/PRKACA/CCL4L2/VAV1/GNGT2/GRK2/WAS/PIK3CG/NFKB1/CXCL9/CXCL12/ADCY3/FGR/CX3CR1/PIK3R5/MAPK1/MAPK3/CRKL/CRK/RELA/CXCL16/PLCB2/AKT2/SOS2/GSK3B/JAK3/ROCK1/PLCB4/AKT1/GRK6/ADCY4	2.72741480752154
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1271	94/9376	1.72650116343305	JUN/FOS/NFKBIA/CXCL8/CXCL1/TRAF5/TAB3/SRSF1/FOSB/MAP3K7/CASP3/NFKB1/CASP8/MAPK1/IFNG/MAPK3/IL17RC/RELA/TRAF3/GSK3B/TRADD/FOSL1	2.80324697880904
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	45/1271	232/9376	1.43085813505521	TMSB4X/GSN/ACTG1/IQGAP2/FN1/EZR/PAK3/ITGAV/ITGB1/PIP4K2A/FGF10/ITGAX/PIKFYVE/BDKRB1/DIAPH2/PIK3CD/CYFIP2/DIAPH1/ARHGEF1/FGD3/NCKAP1L/VAV1/ARHGAP35/FGF7/MYL5/ITGAL/ITGB7/LIMK1/CXCL12/PDGFRB/ARHGEF6/MAPK1/MAPK3/CRKL/CRK/PPP1R12A/ITGB2/AKT2/SOS2/PPP1R12C/ROCK1/AKT1/C6/PDGFB/ITGAM	2.63143159543604
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1271	204/9376	1.44644482497956	DDX5/COL1A2/CD44/ACTG1/FN1/EZR/RPS6/COL1A1/ITGAV/ITGB1/PLCG2/HPSE2/PIK3CD/CAV1/ARHGEF1/PRKACA/MDM2/CDKN1A/VAV1/CASP3/TGFB1/TWIST2/FASLG/MAPK1/FLNA/MAPK3/MYC/PPP1R12A/HSPB2/AKT2/FZD10/GAB1/SOS2/PPP1R12C/ROCK1/AKT1/CAMK2D/TP53/ITPR2/TGFB2	2.55289385364295
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	26/1271	120/9376	1.59832153160241	JUN/CALM1/NFKBIA/PLCG2/PIK3CD/MAP3K1/SH2B1/NFKB1/IRAK3/BAX/FASLG/MAPK1/SH2B2/MAPK3/CRKL/CRK/RELA/MAP3K3/AKT2/GAB1/SOS2/GSK3B/AKT1/CAMK2D/TP53/PSEN1	2.6121342033202
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	23/1271	103/9376	1.64726192203983	CD247/JUN/FOS/NFKBIA/CXCL8/CD3E/PIK3CD/TGFB1/TICAM1/NFKB1/CD3D/FASLG/CASP8/MAPK1/IFNG/MAPK3/RELA/PLCB2/AKT2/ACE/PLCB4/AKT1/TGFB2	2.61559467712144
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	34/1271	168/9376	1.4929376943539	IL2RB/CSH1/AOX1/MCL1/SOCS3/EP300/PIK3CD/LIFR/IL20RB/CDKN1A/PTPN2/OSMR/IL21R/CSF2RA/IL10RA/PDGFRB/PIM1/IFNG/MYC/EPOR/SOCS7/AKT2/IL15RA/PIAS4/CREBBP/SOS2/TYK2/JAK3/STAM/AKT1/STAT5A/IL3RA/PDGFB/IL4R	2.5529712192321
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	40/1271	205/9376	1.43938899656502	GSN/JUN/NFKBIA/SYK/TRAF5/EP300/PIK3CD/CDKN2A/YWHAB/RBL2/PRKACA/TRAF1/MDM2/CDKN1A/GTF2A1/CASP3/RBPJ/DDB1/NFKB1/NFKB2/BAX/SRF/GTF2H1/CASP8/MAPK1/MAPK3/RELA/UBR4/HDAC3/CREBBP/TRAF3/JAK3/PMAIP1/DNAJA3/SKP2/SNW1/TRADD/GTF2E1/TP53/STAT5A	2.51883468231726
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1271	59/9376	1.87547506967689	GADD45A/PIK3CD/CDKN1A/TCF7/GADD45B/BAX/MAPK1/MAPK3/MYC/AKT2/SOS2/GSK3B/AKT1/TP53/AXIN1	2.67124452746325
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1271	49/9376	1.95712840604377	GALNT13/B4GALT2/GALNT7/COLGALT1/FUT11/FUT10/POMT1/GALNT11/B3GLCT/MFNG/OGT/ST3GAL3/GALNT4	2.65998483775546
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1271	71/9376	1.76629248346095	LDHA/SLC16A3/PIK3CD/PFKP/SLC7A5/PDGFRB/SLC1A5/MAPK1/IDH1/MAPK3/MYC/PFKL/AKT2/IDH2/AKT1/TP53/PDHA1	2.56653655996809
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/1271	117/9376	1.57625397593926	ACTG1/SMARCA2/EP400/PHF6/INO80E/BAZ2A/SRCAP/KAT5/SMARCC2/RUVBL1/BCL7C/TRRAP/INO80/MBD3/GATAD2B/BCL7A/INO80B/MTA1/BAZ1A/RSF1/SMARCA1/RBBP7/ING3/CDK2AP1/MRGBP	2.48374340863972
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	19/1271	83/9376	1.68868076554842	EP300/DCAF7/SFMBT1/LCOR/KDM2B/HCFC1/RNF2/FBRS/L3MBTL3/FOXK1/RING1/CBX7/OGT/CREBBP/BAP1/RBBP7/WDR5/PCGF2/FBRSL1	2.49551931191025
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	64/1271	362/9376	1.30419776484345	COL6A1/COL6A3/COL1A2/COL6A2/IL2RB/CSH1/FN1/THBS2/GNG4/TNXB/LAMA2/RPS6/COL1A1/MCL1/ITGAV/LAMB1/ITGB1/FGF10/SYK/SPP1/COL4A1/PIK3CD/PIK3R6/PPP2R5C/YWHAB/RBL2/MDM2/CDKN1A/COL4A2/RPTOR/GNGT2/BCL2L11/FGF7/CRTC2/OSMR/PHLPP1/ITGB7/PIK3CG/LAMC2/NFKB1/TSC2/FASLG/EIF4E2/PDGFRB/PIK3R5/MAPK1/MAPK3/MYC/RELA/EPOR/BRCA1/PKN1/PPP2R5D/GYS1/AKT2/SOS2/GSK3B/LAMC1/JAK3/AKT1/TP53/IL3RA/PDGFB/IL4R	2.33740210567392
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1271	89/9376	1.65772328256084	COL6A1/COL6A3/COL1A2/COL6A2/CD44/FN1/THBS2/TNXB/LAMA2/COL1A1/ITGAV/LAMB1/ITGB1/SPP1/GP1BB/COL4A1/COL4A2/ITGB7/LAMC2/LAMC1	2.46878005452175
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	30/1271	148/9376	1.49531120420184	JUN/FOS/GADD45A/FGF10/PIK3CD/E2F3/CDKN1A/TCF7/DLL1/FGF7/GADD45B/NOTCH1/DLL3/NFKB2/BAX/HEY2/MAPK1/MAPK3/MYC/DVL3/BRCA1/NOTCH4/AKT2/FZD10/JAG2/SOS2/GSK3B/AKT1/TP53/AXIN1	2.40512205445246
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/1271	142/9376	1.50654358883434	ACTG1/JUN/FOS/CALM1/ITGAV/ICAM1/PECAM1/PIK3CD/CAV1/MAP3K7/CDH5/GSTO2/GSTA4/GSTM4/NFKB1/BMPR1A/IFNG/RELA/IL1R1/KEAP1/AKT2/PIAS4/VCAM1/AKT1/GSTM5/BMPR1B/TP53/GSTM2/PDGFB	2.40850728335081
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/1271	73/9376	1.71790090857161	GADD45A/FGF10/PIK3CD/CDKN2A/E2F3/MDM2/CDKN1A/FGF7/GADD45B/BAX/PDGFRB/MAPK1/MAPK3/AKT2/AKT1/TP53/PDGFB	2.43835158435327
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1271	57/9376	1.8118624649744	ACSL4/ACADSB/ACACA/ACOX3/FADS1/ACSL5/ECHS1/FADS2/HSD17B4/ELOVL5/ELOVL3/HADH/PPT2/CPT1A	2.43454125790891
NA	NA	hsa04981	Folate transport and metabolism	9/1271	31/9376	2.14167153117941	FOLR2/SLCO2B1/DHFR2/ABCC4/TYMS/MTHFR/SLC19A1/SHMT1/MTHFD1	2.52124046935184
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	22/1271	103/9376	1.57564183847288	COL3A1/COL6A1/COL6A3/COL1A2/COL15A1/COL6A2/ACE2/COL1A1/COL18A1/COL4A1/FXYD2/COL21A1/COL4A2/SLC36A4/COL7A1/KCNQ1/SLC1A5/SLC3A1/SLC8A1/SLC15A1/ATP1B1/SLC8A2	2.32617689588947
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/1271	109/9376	1.55658695385415	JUN/FOS/NFKBIA/CXCL8/SPP1/PIK3CD/MAP3K7/CCL4L2/RIPK1/TICAM1/NFKB1/CXCL9/CASP8/MAPK1/CD14/MAPK3/RELA/TAB1/AKT2/TRAF3/TYK2/TLR1/AKT1	2.31450750732188
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/1271	170/9376	1.43198037672976	ACTG1/GADD45A/PLCG2/SMARCA2/PIK3CD/CDKN2A/E2F3/CDKN1A/TCF7/TXNRD1/TGFB1/GSTO2/GADD45B/GSTA4/GSTM4/BAX/SMARCC2/MAPK1/MAPK3/MYC/DVL3/KEAP1/AKT2/FZD10/GAB1/SOS2/GSK3B/AKT1/GSTM5/TP53/GSTM2/AXIN1/TGFB2	2.25078959160978
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1271	158/9376	1.44736029638777	GADD45A/EP300/CDKN2A/BUB3/PPP2R5C/PDS5B/YWHAB/RBL2/E2F3/MDM2/ATM/CDKN1A/WAPL/TGFB1/CDC26/GADD45B/ESCO2/STAG2/PRKDC/CUL1/MYC/PPP2R5D/KNL1/CREBBP/BUB1/GSK3B/CDKN2D/SKP2/DBF4/TP53/TGFB2	2.24568859265761
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/1271	98/9376	1.58075755872766	GSN/INPP5D/PLCG2/SYK/DNM2/PIK3CD/BIN1/VAV1/MARCKS/WAS/AMPH/LIMK1/PLA2G6/MAPK1/MAPK3/CRKL/CRK/AKT2/ASAP1/AKT1/PLA2G4A	2.28856171604618
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1271	140/9376	1.47537372147915	EGR1/MAP1LC3B/CALM1/GNG4/RPS6/SPP1/PIK3R6/AGTR1/MEF2D/PRKACA/GNGT2/TFAM/PIK3CG/ADCY3/NRF1/PIK3R5/MAPK1/MAPK3/SLC8A1/MEF2B/PLCB2/AKT2/PLCB4/AKT1/BECN1/ADCY4/SLC8A2/ITPR2	2.24408410691892
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1271	128/9376	1.49842643587726	PDE8B/NME2/ENTPD1/GART/PAPSS2/GUK1/PDE10A/PGM1/AK5/GUCY1A2/PDE6D/ADCY3/CANT1/ENTPD4/NT5E/PRUNE1/GMPR/GMPS/APRT/PDE4A/PRPS2/ADCY4/ENTPD6/IMPDH2/ALLC/PAICS	2.24835066358269
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	24/1271	116/9376	1.52624867739222	GAPDH/PFKP/GLYCTK/ALDOA/ACOX3/RPE/ECHS1/IDH1/IDNK/PCCA/TKFC/AGXT2/DLST/SHMT1/PFKL/GCSH/PRPS2/ACO1/IDH2/ENO2/FH/GPI/ACSS2/PDHA1	2.25837689769665
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	24/1271	116/9376	1.52624867739222	ACTG1/EZR/TXK/ITGB1/ICAM1/PLCG2/PTK2B/JAM2/PECAM1/PIK3CD/CD99L2/VAV1/RASSF5/CDH5/ARHGAP35/MYL5/ITGAL/CXCL12/SIPA1/ITGB2/CYBB/VCAM1/ROCK1/ITGAM	2.25837689769665
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/1271	70/9376	1.68614139597617	ACTG1/ABL2/PRF1/LAMA2/ICAM1/SSPN/CAV1/FYN/HLA-DRB5/CASP3/ITGAL/HLA-DQB2/CASP8/EIF4G1/ITGB2/HLA-DOB	2.28172353282248
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/1271	99/9376	1.5647903106597	JUN/FOS/DGKZ/PIK3CD/DGKI/GPCPD1/DGKQ/WAS/TSC2/CHKA/PDGFRB/MAPK1/MAPK3/AKT2/SOS2/RALGDS/AKT1/PLA2G4A/SLC44A4/PDGFB/SLC22A2	2.23708744461634
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	53/1271	300/9376	1.30324678730658	JUN/FOS/GADD45A/DUSP16/FGF10/NFATC3/DUSP6/NFATC1/PTPN5/MAP3K7/PRKACA/MAP3K1/CASP3/TGFB1/PPP3R1/FGF7/GADD45B/RASGRP1/MAPK8IP3/MAP3K10/RELB/NFKB1/NFKB2/ELK4/FASLG/PPM1A/SRF/PDGFRB/MAPK1/RASGRF2/CD14/FLNA/MAPK3/CRKL/MYC/CRK/RELA/IL1R1/MKNK2/MAP3K11/RAPGEF2/MAP3K3/TAB1/AKT2/SOS2/AKT1/TRADD/PLA2G4A/MAPT/TP53/CACNB4/PDGFB/TGFB2	2.11393435167477
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/1271	100/9376	1.54914240755311	CD44/CD38/CD2/GP1BB/CD9/CD3E/HLA-DRB5/CR1/CD22/HLA-DQB2/CD3D/CSF2RA/CD14/CD24/IL1R1/EPOR/CD34/HLA-DOB/IL3RA/IL4R/ITGAM	2.18618302247059
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	34/1271	180/9376	1.39340851473031	PILRA/NFKBIA/SOCS3/SYK/TRAF5/PIK3CD/SRSF1/HLA-DRB5/MAP3K7/CASP3/HCFC1/EIF2B4/HLA-DQB2/PILRB/TICAM1/NFKB1/EIF2B3/BAX/TSC2/FASLG/CASP8/IFNG/RELA/APAF1/TAB1/AKT2/MAVS/TRAF3/TYK2/AKT1/TRADD/TP53/HLA-DOB/SRSF5	2.11038859150676
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1271	18/9376	2.45895620246525	HCFC1/MTRR/ZNF143/ABCD4/MMAA/MMACHC	2.45340299257416
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/1271	83/9376	1.59980283051956	NFKBIA/CCL4L2/RIPK1/G3BP1/CASP3/DNASE2/NFKB1/POLR1C/CASP8/ZCCHC3/POLR3D/RELA/POLR3F/MAVS/IFI16/NLRP3/GSDME/CASP1	2.17345920167818
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1271	23/9376	2.24513392399001	ACE2/ENPEP/AGTR1/LNPEP/PREP/AGT/ACE	2.36748055390772
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	37/1271	201/9376	1.3579310371823	DDX5/IL2RB/NFKBIZ/PBX1/GADD45A/CXCL8/DUSP6/TRAF1/MDM2/ATM/CDKN1A/PRCC/GADD45B/ITGB7/NFKB1/LMO2/ELK4/BAX/JUP/BMP2K/RARA/CD14/MYC/RELA/PPARG/RUNX2/GRIA3/RXRB/ID2/HOXA10/PER2/SMAD1/HHEX/PAX8/DOT1L/TP53/ITGAM	2.03131022683528
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1271	90/9376	1.55733892822799	SOD2/PIK3CD/PRKACA/RPTOR/KL/NFKB1/BAX/TSC2/ADCY3/EIF4E2/EHMT1/RELA/PPARG/ULK1/AKT2/AKT1/ADCY4/TP53/EHMT2	2.1038181476925
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1271	39/9376	1.89150477112712	GART/SARDH/AHCYL2/DHFR2/TYMS/MTHFR/AHCYL1/SHMT1/GCSH/MTHFD1	2.20919575350403
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/1271	50/9376	1.77044846577498	THBS2/CXCL8/ICAM1/PECAM1/LRP1/TGFB1/CR1/ITGAL/IFNG/ITGB2/VCAM1/TGFB2	2.16303125643162
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	26/1271	133/9376	1.44209461497962	CD247/PRF1/KIR2DL4/ICAM1/PLCG2/PTK2B/SYK/NFATC1/ZAP70/PIK3CD/KIR2DL1/KIR2DL3/FYN/VAV1/CASP3/PPP3R1/ITGAL/NCR1/FASLG/MAPK1/IFNG/MAPK3/CD48/ITGB2/TNFRSF10B/SOS2	2.03337028568812
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1271	56/9376	1.7124873552883	PRKACA/CSNK1G1/SCUBE2/IQCE/MGRN1/GRK2/BOC/SMURF2/SPOPL/CSNK1G2/CUL1/MEGF8/GSK3B	2.117605822488
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/1271	115/9376	1.47537372147915	EGR1/NACA/FOS/GATA3/MEF2D/ARHGEF1/PRKACA/CDKN1A/KL/ADCY3/NACA2/MAPK1/MAPK3/MMP17/MMP24/RUNX2/PDE4A/MMP25/PLCB2/RXRB/PLCB4/ADCY4/ITPR2	2.03112687381107
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1271	24/9376	2.15158667715709	HS6ST3/EXTL2/EXT1/HS6ST1/GLCE/XYLT2/XYLT1	2.23682448229911
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1271	104/9376	1.4895600072626	DGKZ/GNPAT/DGKI/CDS2/GPCPD1/AGPAT3/LPIN2/DGKQ/GPAT4/PNPLA6/CHKA/PTDSS2/LPGAT1/PLA2G6/PLB1/GPD2/PLA2G15/PTDSS1/LPCAT3/AGPAT5/PLA2G4A	1.98800647517031
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	18/1271	86/9376	1.54399575503632	JUN/ABL2/PAK3/PLCG2/PIK3CD/CDKN1A/MAPK1/MAPK3/CRKL/MYC/CRK/AKT2/GAB1/SOS2/GSK3B/AKT1/CAMK2D/STAT5A	2.00686788542322
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	29/1271	154/9376	1.38915058191219	ACTG1/JUN/FOS/CALM1/EEF2/CD38/NFATC3/NFATC1/EEF2K/PIK3R6/PRKACA/CDKN1A/PPP3R1/GUCY1A2/PIK3CG/ADCY3/PIK3R5/MAPK1/MAPK3/PPP1R12A/PLCB2/PPP1R12C/ROCK1/PLCB4/ADCY4/CAMK2D/PLA2G4A/CACNB4/ITPR2	1.92817918185421
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/1271	142/9376	1.4026440309837	SOCS3/UBE2G1/WWP1/UBA2/SAE1/HERC2/MDM2/MAP3K1/PPIL2/MGRN1/CDC26/CUL4B/DDB1/UBE2Z/SMURF2/TRIM37/KLHL9/CUL1/VHL/BRCA1/KEAP1/UBR5/FBXO2/UBE2J2/PIAS4/SKP2/TRIM32	1.9144869318228
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1271	75/9376	1.57373196957776	GADD45A/CDKN2A/PPM1D/MDM2/ATM/CDKN1A/CASP3/GADD45B/BAX/TSC2/CASP8/APAF1/TNFRSF10B/PMAIP1/CCNG1/TP53	1.97540779773003
Human Diseases	Infectious disease: viral	hsa05162	Measles	26/1271	136/9376	1.41028370435507	JUN/IL2RB/FOS/RACK1/NFKBIA/CD3E/PIK3CD/MAP3K7/CASP3/NFKB1/BAX/CD3D/FASLG/CASP8/RELA/APAF1/AKT2/MAVS/TRAF3/GSK3B/TYK2/JAK3/AKT1/TRADD/TP53/STAT5A	1.90853285423008
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1271	187/9376	1.34124883770832	JUN/MAP1LC3B/NFKBIA/CXCL8/CXCL1/TRAF5/TAB3/MAP3K7/PSTPIP1/RIPK1/NAIP/DNM1L/TICAM1/NFKB1/ATG16L1/TRPV2/CASP8/MAPK1/MAPK3/RELA/PKN1/GBP3/CYBB/TAB1/PLCB2/MAVS/IFI16/TRAF3/TYK2/PLCB4/NLRP3/NOD1/CASP1/ITPR2	1.86655057679109
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/1271	106/9376	1.4614551014652	NFKBIA/FOLR2/EP300/PIK3CD/E2F3/MDM2/CDKN1A/TCF7/NFKB1/PDGFRB/MAPK1/MAPK3/RELA/SLC19A1/AKT2/CREBBP/SOS2/GSK3B/AKT1/TP53/PDGFB	1.89201432824102
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1271	156/9376	1.37134095906716	NFKBIA/SOCS3/PIK3CD/YWHAB/E2F3/CDKN1A/RIPK1/CASP3/TICAM1/NFKB1/BAX/FASLG/CASP8/MAPK1/IFNG/MAPK3/MYC/RELA/APAF1/AKT2/MAVS/SOS2/TRAF3/GSK3B/TYK2/AKT1/PPARA/TRADD/TP53	1.85204526670795
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1271	53/9376	1.67023440167451	DNM2/FXYD2/PRKACA/KL/AP2A2/AP2A1/DNM3/SLC8A1/PLCB2/PLCB4/ATP1B1/SLC8A2	1.9376204615597
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1271	31/9376	1.90370802771503	GLYCTK/PCCA/AGXT2/SHMT1/GCSH/ACO1/AFMID/ACSS2	1.99572748354291
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/1271	42/9376	1.75639728747518	CYP1B1/AOX1/KYNU/GCDH/ALDH3A2/KYAT3/ECHS1/DLST/AFMID/HADH	1.94546137845514
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1271	42/9376	1.75639728747518	MAP1LC3B/ACSL4/PRNP/SLC39A8/ACSL5/CYBB/GCLC/LPCAT3/TP53/SLC7A11	1.94546137845514
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1271	65/9376	1.58886400774678	DGAT1/DGKZ/DGKI/LIPG/ALDH3A2/GK/AGPAT3/LPIN2/GLYCTK/DGKQ/GPAT4/TKFC/AGPAT5/ABHD16A	1.88649400441765
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	15/1271	71/9376	1.55849336775967	CGA/FOS/SOCS3/LHCGR/PIK3CD/NFKB1/MAPK1/MAPK3/RELA/SOCS7/AKT2/SOS2/GSK3B/AKT1/STAT5A	1.87055684062171
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1271	21/9376	2.10767674497021	CHST15/DSEL/CHPF2/CHST12/XYLT2/XYLT1	2.01225350893867
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1271	21/9376	2.10767674497021	BCAT1/ALDH3A2/CSAD/PPCDC/PANK3/PANK2	2.01225350893867
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1271	66/9376	1.5647903106597	JUN/RORA/GATA3/NFATC1/HLA-DRB5/TGFB1/HLA-DQB2/IL21R/NFKB1/IFNG/RELA/HLA-DOB/IL4R/TGFB2	1.82333416065865
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1271	72/9376	1.53684762654078	RNF125/NFKBIA/CXCL8/MAP3K7/MAP3K1/RIPK1/NFKB1/OTUD5/CASP8/ZNFX1/RELA/TKFC/MAVS/TRAF3/TRADD	1.81077436932503
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1271	103/9376	1.43240167133898	PABPC1/SYMPK/PPP2R5C/NCBP1/CSTF1/EIF4A3/PABPC4/SMG5/CSTF2/GSPT1/PPP2R5D/DAZAP1/TARDBP/WDR82/CSTF2T/SMG1/CPSF7/NCBP2/BCL2L2-PABPN1/CLP1	1.74734133342554
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	23/1271	122/9376	1.39072113090248	FOS/CSH1/SOCS3/PLCG2/EP300/PIK3CD/PRKACA/MAP3K1/ADCY3/MAPK1/MAPK3/CRKL/CRK/PLCB2/AKT2/CREBBP/SOS2/GSK3B/PLCB4/AKT1/ADCY4/STAT5A/ITPR2	1.72014069673074
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1271	130/9376	1.36188343521152	COL3A1/COL1A2/JUN/FOS/GNG4/NFKBIA/COL1A1/COL4A1/PIK3CD/PRKACA/COL4A2/GNGT2/TGFB1/NFKB1/ADCY3/MAPK1/MAPK3/RELA/PLCB2/AKT2/SOS2/PLCB4/AKT1/ADCY4	1.64530091689974
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1271	33/9376	1.78833178361109	BCAT1/DBT/IDH1/AGXT2/DLST/ACO1/IDH2/PDHA1	1.79640698888496
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1271	17/9376	2.16966723746934	PAPSS2/TXNRD1/KYAT3/SEPSECS/PSTK	1.91141049546141
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1271	93/9376	1.42778102078627	EGR1/CGA/JUN/CALM1/PTK2B/PRKACA/MAP3K1/ADCY3/MAPK1/MAPK3/MAP3K3/PLCB2/SOS2/PLCB4/ADCY4/CAMK2D/PLA2G4A/ITPR2	1.64172614835385
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1271	75/9376	1.47537372147915	CGA/GPX3/FXYD2/PRKACA/TTF2/ADCY3/TTF1/PLCB2/TPO/PLCB4/ATP1B1/PAX8/ADCY4/PDIA4/ITPR2	1.63675201320393
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1271	138/9376	1.33638924047024	CALM1/RPS6/SOCS3/PIK3CD/RHOQ/PRKACA/RPTOR/ACACA/TSC2/EIF4E2/SREBF1/MAPK1/SH2B2/MAPK3/CRKL/CRK/MKNK2/GYS1/AKT2/SOS2/GSK3B/AKT1/EXOC7/PRKCI/PPP1R3E	1.57642954035048
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	13/1271	63/9376	1.52221098247849	PRDM6/KMT2D/GCDH/ALDH3A2/COLGALT1/PHYKPL/ECHS1/EHMT1/DLST/SETD1A/HADH/DOT1L/EHMT2	1.64684747493954
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1271	34/9376	1.73573378997547	POLR2A/POLR2B/POLR2M/POLR2J2/POLR1C/POLR1B/POLR3D/POLR3F	1.70185334748082
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1271	158/9376	1.30729317093089	RPS6/PIK3CD/RRAGB/SLC7A5/LPIN2/RPTOR/CLIP1/TSC2/EIF4E2/MIOS/MAPK1/MAPK3/SEC13/WDR24/SEH1L/TELO2/DVL3/ULK1/AKT2/FZD10/ATP6V1E2/NPRL2/SOS2/GSK3B/MAPKAP1/AKT1/SKP2/FLCN	1.54257043848818
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/1271	23/9376	1.92440050627715	B3GAT2/B4GALT2/FKRP/POMT1/CHST10/ST3GAL3	1.75764243545834
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1271	107/9376	1.37885394530762	LDHA/CALM1/EP300/PRKACA/PFKP/PPP3R1/ACACA/CRTC2/PFKL/GYS1/PLCB2/AKT2/CREBBP/PLCB4/AKT1/PPARA/CPT1A/CAMK2D/ITPR2/PDHA1	1.56073498644963
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1271	70/9376	1.47537372147915	NFKBIA/SOCS3/ACSL4/NFKB1/ACSL5/RELA/PRKCQ/POMC/AKT2/RXRB/AKT1/PPARA/CPT1A/TRADD	1.58082781995862
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/1271	133/9376	1.33116425998119	GADD45A/SOD2/EP300/PIK3CD/RBL2/MDM2/ATM/CDKN1A/BCL2L11/TGFB1/GADD45B/FASLG/MAPK1/MAPK3/S1PR4/PLK2/AKT2/CREBBP/SOS2/CDKN2D/AKT1/SKP2/FBXO25/TGFB2	1.52315713223217
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	35/1271	205/9376	1.2594653719944	COL3A1/COL1A2/MT-CO3/SLC25A6/GFPT2/COL1A1/COX4I1/MT-ATP8/GAPDH/PIK3CD/AGTR1/NDUFV1/TGFB1/UQCRC1/NFKB1/PDK3/PDK2/UQCRC2/RELA/CYBB/GYS1/PLCB2/AKT2/AGT/MPC2/ACE/GSK3B/PLCB4/AKT1/PPARA/CAMK2D/NDUFS5/PDHA1/TGFB2/MT-ND4L	1.48740724722067
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/1271	95/9376	1.39772247298025	JUN/FOS/CXCL8/ICAM1/CXCL1/HLA-DRB5/TGFB1/LTB/ATP6V0E2/ITGAL/HLA-DQB2/CXCL12/IFNG/ITGB2/ATP6V1E2/TCIRG1/HLA-DOB/TGFB2	1.54285975701458
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	21/1271	115/9376	1.34708035439401	FOS/GNG4/PIK3CD/PIK3R6/FYN/PRKACA/GNGT2/KCNQ3/PIK3CG/KCNQ1/ADCY3/PIK3R5/MAPK1/MAPK3/PLCB2/AKT2/PLCB4/AKT1/ADCY4/CAMK2D/ITPR2	1.48296845898003
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1271	154/9376	1.29334709350445	NME2/KYNU/BCAT1/RDH12/ALDH3A2/PNPO/ALAS1/AK5/COQ7/DHFR2/PPCDC/PANK3/HMBS/NADK/SHMT1/GUSB/UROS/AFMID/MOCS1/LIPT1/MTHFD1/COQ6/RDH11/GCLC/MPI/PANK2/NMNAT1	1.45348814840101
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1271	109/9376	1.35355387291665	NFKBIA/GFPT2/SOCS3/PIK3CD/SLC27A4/CRTC2/NFKB1/SREBF1/RELA/PRKCQ/OGT/GYS1/AKT2/AGT/GSK3B/AKT1/PPARA/CPT1A/SLC27A1/PPP1R3E	1.47021608652859
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	27/1271	155/9376	1.28500291870765	PDE8B/PBX1/CDKN2A/KMT2D/AGTR1/PRKACA/E2F3/CDKN1A/TCF7/ARMC5/ADCY3/MAPK1/MAPK3/DVL3/POMC/PLCB2/FZD10/AGT/GSK3B/PLCB4/ADCY4/FH/CAMK2D/WDR5/MRAP/ITPR2/AXIN1	1.41679837343838
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/1271	30/9376	1.72126934172568	ACLY/IDH1/DLST/ACO1/IDH2/FH/PDHA1	1.56684889393477
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1271	19/9376	1.94128121247257	HPSE2/HYAL2/IDUA/GUSB/NAGLU	1.62633414479647
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1271	19/9376	1.94128121247257	DBT/DLST/GCSH/LIPT1/PDHA1	1.62633414479647
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1271	85/9376	1.38858703198038	NME2/ENTPD1/TYMP/GUK1/AK5/CANT1/TYMS/ASMTL/ENTPD4/NT5E/GMPR/GMPS/APRT/ENTPD6/IMPDH2/UCK2	1.42511017159469
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1271	54/9376	1.5026954570621	LDHA/BCAT1/AHCYL2/DNMT3A/MTAP/DNMT1/KYAT3/AGXT2/AHCYL1/GCLC/AMD1	1.46699689610129
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1271	54/9376	1.5026954570621	ERCC1/REV1/TELO2/BRCA1/MUS81/FAN1/PMS2/TOP3A/UBE2T/EME2/CENPS	1.46699689610129
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	10/1271	48/9376	1.53684762654078	AOX1/BCAT1/ACADSB/ALDH3A2/DBT/ECHS1/PCCA/AGXT2/HMGCL/HADH	1.47658785242907
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1271	150/9376	1.27865722528193	GADD45A/FGF10/ABCB1/PIK3CD/E2F3/CDKN1A/TCF7/TGFB1/FGF7/GADD45B/BAX/JUP/MAPK1/MAPK3/MYC/DVL3/AKT2/FZD10/RXRB/GAB1/SOS2/GSK3B/AKT1/TP53/AXIN1/TGFB2	1.36235759302445
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	41/1271	250/9376	1.2098064516129	IL2RB/IQSEC1/ARAP2/FOLR2/ACAP1/DNM2/WWP1/CAV1/WIPF2/CYTH4/BIN1/MDM2/CYTH1/IST1/AP2A2/ZFYVE9/GRK2/ARFGAP1/AMPH/AP2A1/SMURF2/RUFY1/DNM3/HGS/IQSEC3/RAB10/RAB22A/ACAP2/ASAP1/IQSEC2/RAB5A/STAM/RAB4A/GRK6/WASHC2A/CHMP6/LDLRAP1/WASHC5/PRKCI/ARFGAP3/ARFGAP2	1.331467330191
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1271	14/9376	2.10767674497021	B3GNT7/ST3GAL2/B4GALT2/ST3GAL3	1.64238375744436
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1271	80/9376	1.3831628638867	RPS6/PLCG2/PIK3CD/BCL2L11/BAX/EIF4E2/PDGFRB/MAPK1/MAPK3/AKT2/GAB1/SOS2/GSK3B/AKT1/PDGFB	1.3628945363657
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1271	37/9376	1.5949986178153	GFPT2/UAP1/PGM1/UAP1L1/FCSK/GNE/MPI/GPI	1.43598047574779
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1271	43/9376	1.54399575503632	GCDH/ACSL4/ACADSB/ALDH3A2/ACOX3/ACSL5/ECHS1/HADH/CPT1A	1.41579707104753
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/1271	212/9376	1.217879251221	ACTG1/SKAP1/CALM1/FYB1/ITGB1/FGF10/PIK3CD/PRKD2/VAV1/RASSF5/FGF7/ITGAL/RAPGEF5/ADCY3/SIPA1/PDGFRB/RALB/MAPK1/MAPK3/CRKL/CRK/FPR1/RAPGEF2/ITGB2/PLCB2/AKT2/P2RY1/RALGDS/PLCB4/AKT1/ADCY4/SIPA1L3/PDGFB/PRKCI/ITGAM	1.27064188792253
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1271	20/9376	1.84421715184894	UAP1/NPL/UAP1L1/GNE/CYB5RL	1.4966007776803
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/1271	308/9376	1.17359273299478	GPX3/TGM2/MT-CO3/SLC25A6/POLR2A/COX4I1/SOD2/TUBA4A/MT-ATP8/TUBB4B/EP300/POLR2B/TUBB3/NDUFV1/CASP3/UQCRC1/AP2A2/DNAH5/TAF4B/ATG2A/PSMD11/TFAM/REST/DCTN5/POLR2J2/AP2A1/PSMC2/MAP3K10/BAX/DNAL1/NRF1/CASP8/UQCRC2/TUBB2A/PSMD12/APAF1/PPARG/ULK1/PLCB2/GRIA3/CREBBP/PLCB4/BECN1/KLC4/NDUFS5/TP53/DNAH1/PSMD13/MT-ND4L	1.22668497827269
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	28/1271	166/9376	1.2442910904041	CALM1/SLC25A6/NFATC3/NFATC1/FXYD2/PIK3R6/AGTR1/MEF2D/PPP3R1/GUCY1A2/PIK3CG/ADCY3/SRF/PIK3R5/MAPK1/MAPK3/SLC8A1/PPP1R12A/MEF2B/PLCB2/AKT2/ROCK1/PLCB4/AKT1/ATP1B1/ADCY4/SLC8A2/ITPR2	1.25751669871776
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/1271	160/9376	1.24484657749803	NCAM1/VCAN/ITGAV/ITGB1/ICAM1/CD2/PTPRS/JAM2/PECAM1/SPN/HLA-DRB5/CD99L2/CDH5/NLGN1/CD226/CD22/ITGAL/HLA-DQB2/ITGB7/NECTIN3/ICAM3/ITGB2/VCAM1/GLG1/CD34/HLA-DOB/ITGAM	1.23698575946911
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1271	32/9376	1.61369000786782	LDHA/DBT/ACACA/ACOX3/ECHS1/PCCA/ACSS2	1.37701772422832
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1271	32/9376	1.61369000786782	CASP3/BCL2L11/BAX/CASP8/APAF1/PMAIP1/BECN1	1.37701772422832
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1271	38/9376	1.55302496997805	GFPT2/UAP1/PGM1/UAP1L1/FCSK/GNE/MPI/GPI	1.35266891003853
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1271	38/9376	1.55302496997805	AOX1/CD38/SIRT7/NNMT/NT5E/NADK/SIRT2/NMNAT1	1.35266891003853
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1271	89/9376	1.32617862604867	TUBA4A/TUBB4B/TUBB3/PRKACA/GUCY1A2/ADCY3/PDGFRB/MAPK1/TUBB2A/MAPK3/PLCB2/SOS2/PLCB4/ADCY4/PDGFB/ITPR2	1.22431926548956
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1271	51/9376	1.44644482497956	ACTG1/PLCG2/PRKACA/ATP6V0E2/KDELR2/KCNQ1/ADCY3/ATP6V1E2/TCIRG1/PDIA4	1.26593196159244
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	21/1271	122/9376	1.26978885865009	EEF2/EEF2K/PIK3CD/PPP2R5C/MAP3K7/PFKP/RPTOR/ACACA/CRTC2/HMGCR/TSC2/SREBF1/RAB10/PPARG/PPP2R5D/PFKL/ULK1/GYS1/AKT2/AKT1/CPT1A	1.18773917913435
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1271	27/9376	1.63930413497683	ACOX3/FADS1/FADS2/HSD17B4/ELOVL5/ELOVL3	1.31731221679866
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1271	238/9376	1.17781935748336	ABL2/CALM1/PAK3/GNG4/PLCG2/RALGAPA2/FGF10/ZAP70/RASAL3/PIK3CD/PRKACA/RASSF5/GNGT2/FGF7/RASGRP1/RASSF1/NFKB1/RAPGEF5/FASLG/PDGFRB/PLA2G6/RALB/MAPK1/RASGRF2/MAPK3/RELA/KSR1/AKT2/GAB1/SOS2/RALGDS/RAB5A/AKT1/SHOC2/PLA2G4A/PDGFB/RGL2/SYNGAP1	1.10033225050319
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1271	71/9376	1.35069425205838	JUN/NFKBIA/CXCL8/PLCG2/CXCL1/JAM2/CASP3/ATP6V0E2/NFKB1/RELA/ATP6V1E2/TCIRG1/NOD1	1.17457712127533
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/1271	157/9376	1.22164703052414	JUN/FOS/MT-CO3/SOCS3/CXCL8/COX4I1/PIK3CD/NDUFV1/CASP3/BCL2L11/TGFB1/UQCRC1/NFKB1/BAX/FASLG/SREBF1/CASP8/UQCRC2/RELA/MAP3K11/PPARG/AKT2/GSK3B/AKT1/PPARA/NDUFS5	1.10905156727675
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1271	65/9376	1.36188343521152	PDE8B/PBX1/AGTR1/PRKACA/ADCY3/POMC/PLCB2/AGT/PLCB4/ADCY4/MRAP/ITPR2	1.15933546938425
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/1271	125/9376	1.23931392604249	PIK3CD/PPP2R5C/FYN/SPTSSB/NSMAF/NFKB1/BAX/MAPK1/MAPK3/S1PR4/S1PR3/RELA/PPP2R5D/PLCB2/AKT2/CERS2/ROCK1/PLCB4/AKT1/TRADD/TP53	1.06662201075685
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1271	41/9376	1.43938899656502	TOPBP1/ATM/RAD51D/SYCP3/BRCA1/MUS81/TOP3A/XRCC3	1.11651830594381
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1271	154/9376	1.19754360509671	CALM1/FXYD2/PIK3R6/PPP2R5C/AGTR1/PRKACA/TPM4/PIK3CG/KCNQ1/ADCY3/PIK3R5/MAPK1/MAPK3/SLC8A1/PPP2R5D/PLCB2/AKT2/AGT/PLCB4/AKT1/ATP1B1/ADCY4/CAMK2D/SLC8A2/CACNB4	0.978797114947812
NA	NA	hsa04517	IgSF CAM signaling	46/1271	299/9376	1.13490286267627	ACTG1/NCAM1/CD96/EZR/PAK3/SRGAP3/INPP5D/ITGB1/ICAM1/PLCG2/TUBA4A/ITGAX/EPB41L3/CD2/PTPRS/TUBB4B/JAM2/PIK3CD/TUBB3/FYN/MTSS1/VAV1/NLGN1/KCNQ3/CD226/ITGAL/CRTAM/PLXNA3/NECTIN3/GRIP1/MAPK1/TUBB2A/MAPK3/ICAM3/PRKCQ/CD48/RAPGEF2/ITGB2/AKT2/DOK1/GSK3B/AKT1/NRP1/CADM4/PRKCI/ITGAM	0.938787927204747
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1271	155/9376	1.1898175173219	ACTG1/THBS2/ITGAV/ITGB1/RAB7B/TUBA4A/PIKFYVE/TUBB4B/TUBB3/HLA-DRB5/DYNC1LI2/ATP6V0E2/HLA-DQB2/MRC1/TUBB2A/CD14/HGS/ITGB2/CYBB/ATP6V1E2/TCIRG1/RAB5A/HLA-DOB/CTSS/ITGAM	0.943615423348141
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1271	101/9376	1.24165115173988	CALM1/EP300/PRKACA/TCF7/ADCY3/MAPK1/MAPK3/DVL3/POMC/PLCB2/FZD10/CREBBP/GSK3B/PLCB4/ADCY4/CAMK2D/MC1R	0.966884283701068
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1271	88/9376	1.25742078535155	CFD/SERPINE2/C1S/PROCR/ITGAX/BDKRB1/C3AR1/CR1/C5AR1/F13A1/C2/ITGB2/C4BPA/C6/ITGAM	0.96073972301576
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1271	75/9376	1.27865722528193	GAPDH/BCAT1/PFKP/ALDOA/RPE/ARG2/IDH1/SHMT1/PFKL/PRPS2/ACO1/IDH2/ENO2	0.95944044415174
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1271	184/9376	1.16265863920911	SEMA4D/PAK3/SRGAP3/ITGB1/PLCG2/TRPC4/NFATC3/PIK3CD/FYN/SEMA5A/PPP3R1/MYL5/LIMK1/PLXNA3/BOC/CXCL12/MAPK1/EFNB1/MAPK3/RGMA/PLXNB2/NTN4/GDF7/RHOD/GSK3B/ROCK1/NRP1/CAMK2D/BMPR1B	0.882394804332096
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1271	69/9376	1.28293367085143	INPP5D/PLCG2/SYK/PIK3CD/FYN/VAV1/MAPK1/MAPK3/AKT2/SOS2/AKT1/PLA2G4A	0.934084631203108
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1271	76/9376	1.26183278810717	SLC27A4/ACSL4/PPARD/GK/PLIN2/ACOX3/ACSL5/PPARG/FADS2/RXRB/PPARA/CPT1A/SLC27A1	0.907551452214123
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1271	76/9376	1.26183278810717	ACTG1/CALM1/EZR/PRKACA/KCNQ1/ADCY3/GAST/PLCB2/PLCB4/ATP1B1/ADCY4/CAMK2D/ITPR2	0.907551452214123
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/1271	63/9376	1.2880246774818	POLR2A/POLR2B/ERCC1/POLR2M/ERCC5/CUL4B/POLR2J2/DDB1/GTF2H1/UVSSA/ERCC6	0.908316233756563
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1271	144/9376	1.1782498470146	PIK3CD/LIFR/ZFHX3/TCF7/ID4/REST/SMAD5/BMPR1A/MAPK1/MAPK3/MYC/DVL3/AKT2/FZD10/KLF4/ID2/GSK3B/JAK3/AKT1/SMAD1/BMPR1B/PCGF2/AXIN1	0.853580367755752
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1271	37/9376	1.39562379058839	ICAM1/FASLG/IFNG/PLCB2/APOL1/VCAM1/PLCB4	0.954805644947918
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/1271	250/9376	1.12128402832415	PIKFYVE/FUCA1/RRAGB/AP1B1/VPS39/MANBA/SLC36A4/RPTOR/OSBPL2/AP2A2/LAPTM4B/ATP6V0E2/DNASE2/ZFYVE26/AP2A1/MEAK7/LIPA/HYAL2/SPG11/AP3D1/ENTPD4/TELO2/TPCN2/PLA2G15/IDUA/CTNS/GUSB/ATP6V1E2/TCIRG1/OSBPL5/NAGLU/PPT2/MCOLN2/AP4M1/SLC11A1/CTSS/DMXL2/OSBPL7	0.769689016453677
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1271	78/9376	1.22947810123263	BTG1/PABPC1/CNOT6L/PFKP/EXOSC7/PATL1/DDX6/CNOT1/PABPC4/PFKL/ENO2/TOB1/EDC4	0.8058898427425
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1271	13/9376	1.7023542940144	DCLRE1C/PRKDC/XRCC6	1.0034651871756
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/1271	45/9376	1.31144330798147	PRF1/KIR2DL1/KIR2DL3/HLA-DRB5/HLA-DQB2/FASLG/IFNG/HLA-DOB	0.829283586287782
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1271	32/9376	1.3831628638867	ATG4B/RPTOR/ATG2A/ATG16L1/BECN1/IGBP1	0.859753373973325
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1271	65/9376	1.2483931489439	CGA/TRPC4/SPP1/PIK3CD/MAPK1/MAPK3/PLCB2/AKT2/PLCB4/AKT1/ITPR2	0.795756201867552
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1271	99/9376	1.19222118907406	CALM1/PLCG2/BDKRB1/PIK3CD/PRKACA/TRPV2/ADCY3/PLA2G6/IL1R1/PRKCQ/PLCB2/PLCB4/ADCY4/CAMK2D/PLA2G4A/ITPR2	0.76137214210443
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1271	26/9376	1.41862857834534	ACOX3/PLA2G6/PLB1/FADS2/PLA2G4A	0.846431164705362
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1271	26/9376	1.41862857834534	PLB1/SLC19A1/ABCD4/MMACHC/CUBN	0.846431164705362
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1271	59/9376	1.25031671311792	NME2/ENTPD1/TYMP/CANT1/TYMS/ASMTL/ENTPD4/NT5E/ENTPD6/UCK2	0.763764923992212
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1271	59/9376	1.25031671311792	GPX3/GSTO2/HPGDS/GSTA4/GSTM4/IDH1/IDH2/GCLC/GSTM5/GSTM2	0.763764923992212
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1271	93/9376	1.1898175173219	ACTG1/EP300/FYN/MAP3K7/TCF7/CDH5/MYL5/WAS/SMURF2/NECTIN3/MAPK1/MAPK3/PTPRB/CREBBP/ROCK1	0.728476408397415
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	54/1271	368/9376	1.0824752847809	GPX3/ACTG1/MAP1LC3B/MT-CO3/COX4I1/HNRNPA1/TUBA4A/MT-ATP8/TUBB4B/NUP210L/TUBB3/NCBP1/NUP205/NDUFV1/SETX/CASP3/UQCRC1/PPP3R1/DNAH5/ATG2A/PSMD11/NUP43/DCTN5/PSMC2/CCS/BAX/DNAL1/SPG11/TPR/UQCRC2/TUBB2A/TOMM40/SEC13/SEH1L/PSMD12/APAF1/NUP50/TARDBP/ULK1/NUP62/RAB5A/BECN1/NUP153/KLC4/NDUFS5/TP53/DNAH1/UBQLN2/NUP107/HNRNPA1L2/PSMD13/CASP1/RAE1/MT-ND4L	0.639168624625897
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/1271	157/9376	1.12767418202228	ACTG1/PATJ/BMP8B/YWHAB/TCF7/TGFB1/LATS2/RASSF1/BMPR1A/MYC/DVL3/SAV1/ITGB2/GDF7/FZD10/ID2/GSK3B/TP53BP2/SMAD1/BMPR1B/PRKCI/LLGL2/AXIN1/TGFB2	0.63884118518415
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1271	67/9376	1.21112768181124	LDHA/GAPDH/ALDH3A2/PFKP/PGM1/ALDOA/PFKL/ENO2/GPI/ACSS2/PDHA1	0.686772614788202
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1271	67/9376	1.21112768181124	CALM1/EP300/PRKACA/PPP3R1/MAPK1/MAPK3/PLCB2/CREBBP/PLCB4/CAMK2D/ITPR2	0.686772614788202
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1271	61/9376	1.20932272252389	MT2A/FXYD2/SLC31A1/ATP7A/MT1G/SLC8A1/ATP1B1/MT1M/SLC8A2/SLC30A1	0.649488949710503
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1271	34/9376	1.3018003424816	RORA/NR1D2/CUL1/CRY1/BHLHE40/PER2	0.698105660119671
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1271	48/9376	1.22947810123263	FXYD2/PIK3CD/SLC2A5/PLCB2/AKT2/PLCB4/AKT1/ATP1B1	0.631174582743253
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1271	28/9376	1.31729796560638	ECHS1/ELOVL5/ELOVL3/HADH/PPT2	0.665838426449082
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1271	97/9376	1.14075287743233	FOS/CALM1/GNG4/PRKACA/GNGT2/GUCY1A2/ADCY3/MAPK1/MAPK3/PLCB2/GRIA3/PLCB4/PER2/ADCY4/CAMK2D	0.551790813213932
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1271	35/9376	1.26460604698213	PFKP/ALDOA/TKFC/FCSK/PFKL/MPI	0.621039187280108
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1271	63/9376	1.17093152498345	GADD45A/CDKN1A/TCF7/GADD45B/BAX/DVL3/FZD10/GSK3B/TP53/AXIN1	0.539050613165073
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1271	105/9376	1.12409426398411	ACTG1/LAMA2/ITGAV/ITGB1/SSPN/PRKACA/TPM4/TGFB1/ITGB7/ADCY3/SLC8A1/AGT/ADCY4/SLC8A2/CACNB4/TGFB2	0.506366505076764
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	34/1271	233/9376	1.07645292983457	COL3A1/COL6A1/FBLN1/COL6A3/COL1A2/COL6A2/ACTG1/VIM/FN1/THBS2/VCAN/LAMA2/COL1A1/ITGAV/ITGB1/DIAPH2/COL4A1/SSPN/DIAPH1/FMNL3/TPM4/SUN1/COL4A2/MYL5/ITGB7/LMNB1/JUP/CAPN3/BGN/LMNB2/ENO2/ATP1B1/FHL3/FMNL1	0.467960975524631
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1271	29/9376	1.27187389782685	RASSF4/LATS2/RASSF1/RASSF2/SAV1	0.580647145243534
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1271	36/9376	1.22947810123263	KL/RPE/XYLB/GUSB/FGGY/DHDH	0.546261966621234
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1271	36/9376	1.22947810123263	GCNT1/GALNT13/ST3GAL2/GALNT7/GALNT11/GALNT4	0.546261966621234
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/1271	99/9376	1.11770736475693	CFD/C1S/ICAM1/HLA-DRB5/C3AR1/ITGAL/HLA-DQB2/C5AR1/C2/FPR1/KRT19/ITGB2/PTAFR/HLA-DOB/ITGAM	0.466229081602047
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1271	16/9376	1.3831628638867	ST3GAL2/B3GALT5/GBGT1	0.607417613990962
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1271	23/9376	1.28293367085143	DHDDS/HMGCR/NUS1/MVD	0.537966198559596
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1271	44/9376	1.17359273299478	GTF2F1/GTF2A1/TAF4B/TAF8/GTF2H1/TAF12/GTF2E1	0.457038112713123
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/1271	44/9376	1.17359273299478	PRF1/HLA-DRB5/HLA-DQB2/FASLG/IFNG/ICA1/HLA-DOB	0.457038112713123
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	21/1271	144/9376	1.07579333857855	SLC25A6/RORA/PIK3CD/AFG3L2/KAT5/ATG2A/PSMD11/PSMC2/RBPJ/PSMD12/ULK1/PLCB2/AKT2/GRIA3/PLCB4/AKT1/BECN1/ATXN3/BEAN1/PSMD13/ITPR2	0.362949572753426
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1271	73/9376	1.11158294084046	EP300/TNPO3/MAP1A/HGS/TRIM5/NELFE/CREBBP/CPSF7/NUP153/CHMP6/APOBEC3H	0.378991637058197
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	31/1271	217/9376	1.05383837248511	CYP1B1/JUN/FOS/FGF10/PIK3CD/PRKACA/DLL1/KPNA2/FGF7/GSTO2/DLL3/GSTA4/GSTM4/NFKB1/ADCY3/MAPK1/MAPK3/MYC/RELA/AKT2/KLF4/RXRB/EPHX2/SOS2/AKT1/PPARA/ADCY4/GSTM5/STAT5A/GSTM2/KPNB1	0.317745686915113
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1271	45/9376	1.14751289448378	ABCB1/ABCG1/ABCG8/ABCC4/ABCA7/ABCD4/ABCD1	0.392784237214956
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1271	17/9376	1.3018003424816	ACOT8/HSD17B4/AMACR	0.493186714711505
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1271	38/9376	1.16476872748354	FXYD2/PIK3CD/MAPK1/MAPK3/ATP1B1/NR3C2	0.403015319583925
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1271	38/9376	1.16476872748354	ZAP70/CD3E/DCLRE1C/CD3D/RFXANK/JAK3	0.403015319583925
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	32/1271	226/9376	1.04451236918878	CGA/JUN/FOS/CALM1/NFKBIA/LHCGR/NFATC1/FXYD2/EP300/PIK3CD/PRKACA/VAV1/PDE10A/ACOX3/NFKB1/ADCY3/ABCC4/MAPK1/MAPK3/RELA/PPP1R12A/POMC/PDE4A/AKT2/GRIA3/CREBBP/ROCK1/AKT1/PPARA/ATP1B1/ADCY4/CAMK2D	0.268229343605041
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	32/1271	227/9376	1.03991099311306	CYP1B1/JUN/FOS/ABL2/MT-CO3/SLC25A6/NFKBIA/COX4I1/SOD2/MT-ATP8/PIK3CD/PRKD2/NDUFV1/SLC26A2/UQCRC1/GSTO2/GSTA4/GSTM4/NFKB1/UQCRC2/MAPK1/MAPK3/RELA/KEAP1/AKT2/EPHX2/SOS2/AKT1/GSTM5/NDUFS5/GSTM2/MT-ND4L	0.241046346443568
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1271	82/9376	1.07954174742377	NME2/TYMP/CES1/GSTO2/GSTA4/GSTM4/GMPS/GUSB/GSTM5/IMPDH2/GSTM2/UCK2	0.286472292561652
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/1271	169/9376	1.0476026424704	MAP1LC3B/DAPK2/RAB7B/PIK3CD/ATG4B/MAP3K7/PRKACA/RRAGB/VPS39/RPTOR/MTMR4/ATG2A/ATG16L1/TSC2/MAPK1/MAPK3/PRKCQ/ZFYVE1/ULK1/AKT2/AKT1/BECN1/IGBP1/DAPK1	0.247284699775025
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/1271	39/9376	1.13490286267627	PRF1/HLA-DRB5/HLA-DQB2/FASLG/IFNG/HLA-DOB	0.334296395276899
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1271	32/9376	1.15263571990559	PFKP/B4GALT2/PGM1/PFKL/GANC	0.342489023718327
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1271	18/9376	1.22947810123263	ACSL4/ACACA/ACSL5	0.385893873539887
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1271	18/9376	1.22947810123263	FUCA1/MANBA/ENGASE	0.385893873539887
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1271	134/9376	1.0459739070188	CALM1/AGTR1/ARHGEF1/PRKACA/GUCY1A2/ADCY3/PLA2G6/MAPK1/MAPK3/PRKCQ/PPP1R12A/PLCB2/AGT/PPP1R12C/ROCK1/PLCB4/ADCY4/PLA2G4A/ITPR2	0.212257348184979
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/1271	105/9376	1.05383837248511	JUN/MAP1LC3B/RABGEF1/RAB7B/SMURF2/TOMM40/TOMM70/RELA/TBC1D17/ULK1/RAB5A/BECN1/SAMM50/TP53/PGAM5	0.219687418572341
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1271	47/9376	1.0986825585483	LDHA/ALDH3A2/ACACA/ACYP2/FH/ACSS2/PDHA1	0.268567642704901
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1271	69/9376	1.0691113923762	CALM1/AGTR1/PRKACA/PPP3R1/GUCY1A2/PLCB2/AGT/ACE/PLCB4/ITPR2	0.228166160872206
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1271	33/9376	1.11770736475693	VAMP5/VAMP1/BNIP1/STX2/STX19	0.268225050782551
Cellular Processes	Cell motility	hsa04814	Motor proteins	27/1271	194/9376	1.0266775896891	ACTG1/TUBA4A/TUBB4B/TUBB3/TPM4/KIF2A/KIF9/KIF6/DNAH5/DYNC1LI2/MYO1C/MYL5/DCTN5/MYO1F/MYO1G/DNAL1/KIF21B/KIF15/TUBB2A/KIF11/STARD9/KIF13B/KIF17/KLC4/MYO15B/DNAH1/BICDL1	0.14868279388782
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	38/1271	275/9376	1.01934911665832	EGR1/NCAM1/MT-CO3/SLC25A6/COX4I1/TUBA4A/MT-ATP8/TUBB4B/PIK3CD/TUBB3/CAV1/FYN/PRKACA/NDUFV1/PRNP/CASP3/UQCRC1/STIP1/PPP3R1/PSMD11/NOTCH1/PSMC2/BAX/UQCRC2/MAPK1/TUBB2A/MAPK3/PSMD12/APAF1/CYBB/GSK3B/LAMC1/KLC4/C6/NDUFS5/PSMD13/ITPR2/MT-ND4L	0.128962913679905
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1271	99/9376	1.0431935404398	ACTG1/LAMA2/ITGAV/ITGB1/SSPN/TPM4/TGFB1/ITGB7/SLC8A1/AGT/ACE/SLC8A2/CACNB4/TGFB2	0.171086021099664
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1271	63/9376	1.05383837248511	PTGDS/LTC4S/HPGDS/PTGR2/PLA2G6/PLB1/PTGIS/EPHX2/PLA2G4A	0.169784992573583
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1271	41/9376	1.07954174742377	SARDH/ALAS1/GLYCTK/AGXT2/SHMT1/GCSH	0.202121167757222
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1271	12/9376	1.22947810123263	COQ7/COQ6	0.314980067800554
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1271	93/9376	1.03117518167898	CST3/CALM1/CD38/FXYD2/LYZ/PRKACA/GUCY1A2/ADCY3/PLCB2/PLCB4/ATP1B1/ADCY4/ITPR2	0.11964324842646
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1271	20/9376	1.10653029110936	LIPA/CYP51A1/NSDHL	0.188853443893674
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1271	50/9376	1.03276160503541	HLA-DRB5/TGFB1/HLA-DQB2/ITGB7/CXCL12/IL15RA/HLA-DOB	0.0919780865955359
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1271	44/9376	1.00593662828124	PARG/PNKP/TDP1/XRCC1/APTX/NTHL1	0.0156300631871403
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1271	44/9376	1.00593662828124	NSF/PRKACA/DYNC1LI2/DCTN5/ADCY3/RAB5A	0.0156300631871403
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1271	52/9376	0.993040004841736	CYP1B1/CGA/LHCGR/PRKACA/ADCY3/ADCY4/PLA2G4A	-0.0199292695312884
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1271	52/9376	0.993040004841736	LIPG/LRP1/ABCG8/LIPA/OSBPL5/MYLIP/LDLRAP1	-0.0199292695312884
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1271	60/9376	0.9835824809861	PLCG2/PIK3CD/PPP3R1/MAPK1/MAPK3/AKT2/AKT1/PLA2G4A	-0.0505184848918693
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1271	60/9376	0.9835824809861	GUCY1A2/MAPK1/MAPK3/PLCB2/GRIA3/PLCB4/PLA2G4A/ITPR2	-0.0505184848918693
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1271	98/9376	0.978564203021885	CALM1/AGTR1/PRKACA/PRKD2/ADCY3/POMC/PLCB2/AGT/PLCB4/ATP1B1/ADCY4/CAMK2D/ITPR2	-0.0844709527750738
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1271	91/9376	0.972773882293945	PDE8B/GNG4/PRKACA/PDE10A/GNGT2/GABRB3/GRK2/GABRA2/ADCY3/PDE4A/GRK6/ADCY4	-0.103346878519885
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1271	69/9376	0.962200253138576	JUN/FOS/CALM1/ARC/FOSB/PRKACA/PPP3R1/GRIA3/CAMK2D	-0.124793074293245
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	22/1271	168/9376	0.966018508111348	SLC25A6/TRAF5/RIPK1/DNM1L/TICAM1/BAX/FASLG/CASP8/IFNG/CYBB/TNFRSF10B/CAPN1/TYK2/JAK3/TRADD/CAMK2D/CHMP6/PLA2G4A/STAT5A/NLRP3/CASP1/PGAM5	-0.175993379633922
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	18/1271	138/9376	0.962200253138576	CALM1/PPP2R5C/YWHAB/PRKACA/PPP3R1/CDC26/CPEB3/ADCY3/MAPK1/CUL1/MAPK3/SPDYE3/PPP2R5D/BUB1/ADCY4/CAMK2D/AURKA/ITPR2	-0.177141924892777
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1271	54/9376	0.956260745403153	CGA/PRF1/HLA-DRB5/HLA-DQB2/FASLG/TPO/HLA-DOB	-0.127642591214888
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/1271	62/9376	0.951854013857516	SOD2/PIK3CD/PRKACA/RPTOR/ADCY3/AKT2/AKT1/ADCY4	-0.150615517502518
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1271	23/9376	0.962200253138576	MLH3/PMS2/MSH6	-0.0718719198897779
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1271	23/9376	0.962200253138576	FXYD2/CA4/ATP1B1	-0.0718719198897779
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1271	139/9376	0.955277949159162	JUN/FOS/CALM1/PIK3CD/PRKACA/ADCY3/RARA/MAPK1/MAPK3/KRT19/POMC/PLCB2/AKT2/SOS2/PLCB4/AKT1/ADCY4/ITPR2	-0.21035146604919
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1271	31/9376	0.951854013857516	ALDH3A2/CSAD/ACOX3/ECHS1	-0.106324459692782
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/1271	78/9376	0.945752385563558	ACTG1/FN1/ITGB1/DNM2/PIK3CD/CAV1/DNM3/CRKL/CRK/GAB1	-0.190508816451392
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1271	86/9376	0.943552961411084	ACTG1/LAMA2/ITGAV/ITGB1/SSPN/TCF7/ITGB7/JUP/SLC8A1/SLC8A2/CACNB4	-0.208240134086665
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1271	110/9376	0.938874186395823	PIK3CD/PRKACA/CDC26/CPEB3/ADCY3/MAPK1/MAPK3/SPDYE3/STK10/AKT2/BUB1/AKT1/ADCY4/AURKA	-0.255362282361662
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/1271	87/9376	0.932707525073026	MT-CO3/COX4I1/FXYD2/TPM4/UQCRC1/UQCRC2/SLC8A1/ATP1B1/SLC9A7/SLC8A2/CACNB4	-0.249702879260434
Human Diseases	Immune disease	hsa05310	Asthma	4/1271	32/9376	0.922108575924469	PRG2/HLA-DRB5/HLA-DQB2/HLA-DOB	-0.174775326536672
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/1271	174/9376	0.932707525073026	UBE2G1/DNAJA1/EDEM1/NGLY1/PRKCSH/HYOU1/BAX/UBXN1/CUL1/SEC13/MBTPS1/HERPUD1/FBXO2/UBXN6/UBE2J2/CAPN1/BAG1/SEC24A/HSPBP1/ATXN3/UBQLN2/PDIA4	-0.354798614252767
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	62/1271	480/9376	0.952845528455285	GPX3/MAP1LC3B/CALM1/MT-CO3/SLC25A6/COX4I1/TUBA4A/MT-ATP8/TUBB4B/UBE2G1/TUBB3/NDUFV1/PRNP/CASP3/UQCRC1/PPP3R1/DNAH5/ATG2A/PSMD11/DCTN5/PSMC2/MAP3K10/NFKB1/CCS/BAX/FASLG/DNAL1/SPG11/CASP8/UQCRC2/MAPK1/TUBB2A/MAPK3/TOMM40/DVL3/RELA/PSMD12/APAF1/ZFYVE1/UBE2J2/TARDBP/ULK1/CYBB/PLCB2/FZD10/GRIA3/CAPN1/GSK3B/RAB5A/PLCB4/BECN1/ATXN3/KLC4/CAMK2D/NDUFS5/MAPT/DNAH1/PSMD13/ITPR2/AXIN1/PSEN1/MT-ND4L	-0.419979427862077
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1271	17/9376	0.867866894987735	CSAD/ADO	-0.215925175663448
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1271	17/9376	0.867866894987735	CA13/CA4	-0.215925175663448
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	41/1271	323/9376	0.936382702486767	CYP1B1/CD44/VIM/EZR/TNXB/MCL1/PLCG2/ABCB1/EP300/PIK3CD/CDKN2A/DNMT3A/ZEB2/E2F3/MDM2/ATM/CDKN1A/RPTOR/MARCKS/CASP3/BCL2L11/DNMT1/NOTCH1/RASSF1/NFKB1/PDGFRB/MAPK1/PIM1/MAPK3/CRKL/MYC/CRK/BRCA1/NOTCH4/CREBBP/SOS2/ROCK1/CCNG1/TP53/PDGFB/TGFB2	-0.460746580832698
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1271	59/9376	0.875221699182547	CGA/PIK3CD/PRKACA/ADCY3/AKT2/AKT1/ADCY4	-0.380722838090412
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1271	116/9376	0.890311728478798	GNG4/PRKACA/GNGT2/PPP3R1/GRK2/ADCY3/MAPK1/MAPK3/PLCB2/GRIA3/PLCB4/ADCY4/PLA2G4A/ITPR2	-0.470723194173716
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1271	195/9376	0.907922290141016	ACTG1/SLC25A6/PLCG2/SYK/PIK3CD/MAP3K7/CR1/ITGAL/C5AR1/NFKB1/MAPK1/MAPK3/RELA/FPR1/HDAC3/ITGB2/CYBB/PLCB2/AKT2/PLCB4/AKT1/AZU1/CASP1/ITGAM	-0.514527658081601
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1271	27/9376	0.819652067488417	ECHS1/HMGCL/HADH	-0.371614262717849
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/1271	388/9376	0.931614849903072	CALM1/MT-CO3/SLC25A6/COX4I1/TUBA4A/MT-ATP8/GAPDH/TUBB4B/PIK3CD/TUBB3/LRP1/NDUFV1/SLC39A8/CASP3/UQCRC1/PPP3R1/ATG2A/PSMD11/PSMC2/NFKB1/SLC39A9/CASP8/UQCRC2/MAPK1/TUBB2A/MAPK3/DVL3/RELA/PSMD12/APAF1/ULK1/CYBB/PLCB2/AKT2/FZD10/CAPN1/SLC39A1/GSK3B/PLCB4/AKT1/BECN1/KLC4/NDUFS5/MAPT/PSMD13/ITPR2/AXIN1/PSEN1/MT-ND4L	-0.544788635298985
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1271	44/9376	0.838280523567699	MGAT4C/B4GALT2/B4GALNT3/ALG11/ST3GAL3	-0.425777986338842
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1271	36/9376	0.819652067488417	PGM1/GANC/GYS1/GPI	-0.429309880815088
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1271	28/9376	0.79037877936383	B4GALT2/B3GALT5/ST3GAL3	-0.439882630296683
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1271	28/9376	0.79037877936383	ATP6V0E2/ATP6V1E2/TCIRG1	-0.439882630296683
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	33/1271	268/9376	0.908345761358432	CALM1/MT-CO3/SLC25A6/COX4I1/TUBA4A/MT-ATP8/TUBB4B/UBE2G1/TUBB3/PRKACA/NDUFV1/SLC39A8/CASP3/UQCRC1/PSMD11/PSMC2/SLC39A9/BAX/UQCRC2/TUBB2A/PSMD12/KEAP1/APAF1/UBE2J2/SLC39A1/KLC4/CAMK2D/NDUFS5/MAPT/TP53/PSMD13/ITPR2/MT-ND4L	-0.602823735832836
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1271	79/9376	0.840402752741288	DNM2/NSF/AP2A2/ATP6V0E2/AP2A1/DNM3/STX2/ATP6V1E2/TCIRG1	-0.564091337353922
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1271	46/9376	0.801833544282147	ALAS1/HMBS/GUSB/UROS/BLVRA	-0.533519306365286
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/1271	46/9376	0.801833544282147	PSMD11/PSMC2/IFNG/PSMD12/PSMD13	-0.533519306365286
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1271	10/9376	0.737686860739575	PAPSS2	-0.328643367566228
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/1271	170/9376	0.867866894987735	ACTG1/JUN/EZR/ITGB1/TUBA4A/PATJ/SYMPK/RAB13/JAM2/PRKACA/MAP3K1/TJAP1/WAS/RAP2C/RAPGEF2/ARHGEF18/ROCK1/MARVELD2/PRKCI/LLGL2	-0.688466035703135
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1271	30/9376	0.737686860739575	PIGG/PGAP2/PGAP1	-0.56983574420535
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1271	30/9376	0.737686860739575	PLA2G6/PLB1/PLA2G4A	-0.56983574420535
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1271	82/9376	0.809656310567826	KIR2DL4/KIR2DL1/KIR2DL3/HLA-DRB5/HLA-DQB2/IFNG/RFXANK/HLA-DOB/CTSS	-0.68552923279108
Genetic Information Processing	Transcription	hsa03040	Spliceosome	29/1271	243/9376	0.880367035450522	DDX5/HNRNPC/HNRNPA1/SRSF1/NCBP1/PRPF3/EIF4A3/CDC5L/SMNDC1/DHX38/DHX8/PPIH/TCERG1/SLU7/PUF60/THOC1/PRPF31/CWC25/RBMX2/PRPF40B/SNRNP200/RBM17/CTNNBL1/RBMXL1/SNW1/NCBP2/HNRNPA1L2/DDX42/SRSF5	-0.748219765611859
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1271	31/9376	0.713890510393137	ALDH3A2/KL/GUSB	-0.631837445501706
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1271	31/9376	0.713890510393137	BAG6/GET3/SRP68	-0.631837445501706
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/1271	149/9376	0.841656149837099	GNG4/NAPEPLD/PRKACA/NDUFV1/GNGT2/GABRB3/GABRA2/ADCY3/MAPK1/MAPK3/PLCB2/GRIA3/PLCB4/ADCY4/NDUFS5/ITPR2/MT-ND4L	-0.771517850056008
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1271	49/9376	0.75274169463222	JUN/FOSB/PRKACA/NFKB1/RELA	-0.687163121619157
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/1271	133/9376	0.831977662488243	FOS/CALM1/GNG4/PPP2R5C/PRKACA/GNGT2/PPP2R5D/PLCB2/AKT2/GRIA3/GSK3B/PLCB4/AKT1/CAMK2D/ITPR2	-0.772802058319615
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1271	254/9376	0.8712836937869	CALM1/SLC25A6/PLCG2/CD38/LHCGR/FGF10/PTK2B/BDKRB1/NFATC3/NFATC1/P2RX4/AGTR1/PRKACA/PPP3R1/FGF7/ADCY3/PDGFRB/TPCN2/SLC8A1/PLCB2/PLCB4/TACR2/ADCY4/MCOLN2/PTAFR/CAMK2D/SLC8A2/PDGFB/ITPR2/P2RX6	-0.823544927402866
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1271	12/9376	0.614739050616313	NCAM1	-0.528806536684587
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1271	50/9376	0.737686860739575	ALDH3A2/ARG2/P4HA2/AZIN2/AMD1	-0.736443181338898
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1271	102/9376	0.795544653738758	RAB27B/CD38/FXYD2/KCNQ1/ADCY3/TPCN2/PLCB2/PLCB4/ATP1B1/ADCY4/ITPR2	-0.822142151698502
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/1271	235/9376	0.847555116594406	ACTG1/MT-CO3/RPS6/COX4I1/MT-ATP8/SMARCA2/BMP8B/ACSL4/PRKACA/NDUFV1/RPTOR/UQCRC1/KDM1A/TSC2/SMARCC2/ACSL5/ADCY3/COX18/UQCRC2/PPARG/SOS2/COX19/CPT1A/ADCY4/NDUFS5/KDM3A/MT-ND4L	-0.937199035592551
NA	NA	hsa04081	Hormone signaling	25/1271	219/9376	0.842108288515497	CGA/CSH1/GNG4/ITGAV/LHCGR/PIK3CD/AGTR1/PRKACA/GNGT2/SMAD5/ADCY3/BMPR1A/GAST/EPOR/THRB/POMC/PLCB2/AGT/PLCB4/HAMP/SMAD1/ADCY4/BMPR1B/STAT5A/MC1R	-0.936238910328791
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1271	43/9376	0.686220335571698	DGAT1/SLC27A4/ABCG8/SLC27A1	-0.816639331720899
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1271	70/9376	0.737686860739575	CYP1B1/GSTO2/HPGDS/GSTA4/GSTM4/GSTM5/GSTM2	-0.872307175064885
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1271	79/9376	0.747024669103367	CYP1B1/GSTO2/HPGDS/GSTA4/GSTM4/GSTM5/GSTM2/DHDH	-0.894133170678751
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1271	90/9376	0.737686860739575	FXYD2/ABCB1/PRKACA/ABCG8/HMGCR/ADCY3/ABCC4/ATP1B1/ADCY4	-0.9901679477313
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1271	73/9376	0.707370962353017	AOX1/GSTO2/HPGDS/GSTA4/GSTM4/GSTM5/GSTM2	-0.993914994471854
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/1271	100/9376	0.737686860739575	IL2RB/CXCL8/CXCL1/CCL4L2/IL20RB/CXCL9/CXCL12/IL10RA/CX3CR1/TNFRSF10B	-1.04429110506575
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1271	15/9376	0.49179124049305	ST3GAL2	-0.780025062727895
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1271	15/9376	0.49179124049305	AK5	-0.780025062727895
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1271	56/9376	0.658648982803192	MGAT4C/B4GALT2/ALG11/MGAT3/ALG10	-1.01453997206122
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1271	37/9376	0.598124481680737	AOX1/TPO/FAHD1	-0.969893678251583
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1271	47/9376	0.627818604884745	SOCS3/PIK3CD/MAPK1/MAPK3	-1.01290320615065
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1271	28/9376	0.526919186242554	DHFR2/MOCS1	-0.992743158669566
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1271	86/9376	0.686220335571698	FXYD2/PRKACA/ADCY3/PLCB2/PLCB4/ATP1B1/ADCY4/CAMK2D	-1.15757214244805
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	33/1271	298/9376	0.816901557194831	IL2RB/CSH1/CXCL8/CXCL1/BMP8B/LIFR/CCL4L2/IL20RB/TGFB1/LTB/OSMR/IL21R/CXCL9/CXCL12/FASLG/CSF2RA/IL10RA/BMPR1A/CX3CR1/EDA/IFNG/GDF15/IL17RC/IL1R1/EPOR/CXCL16/GDF7/IL15RA/TNFRSF10B/BMPR1B/IL3RA/IL4R/TGFB2	-1.27197799306884
NA	NA	hsa04519	Cadherin signaling	46/1271	404/9376	0.839940485000506	ACTG1/VIM/NFKBIA/CTNND2/PTK2B/EP300/TMC8/CYFIP2/YWHAB/TMC6/LHFPL3/NCKAP1L/KRT8/TCF7/VAV1/CDH5/GABRB3/ARHGAP35/TMC1/MYO1C/KRT7/LATS2/MYO1F/GABRA2/MYO1G/NFKB1/FMN1/LHFPL5/JUP/PDGFRB/MAPK1/MAPK3/DVL3/RELA/SAV1/KRT19/FZD10/PRICKLE3/CREBBP/GSK3B/ROCK1/SHOC2/ANKRD6/PCDHB9/AXIN1/PSEN1	-1.30229523220176
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1271	115/9376	0.705613518968289	GNG4/PRKACA/CASP3/GNGT2/GABRB3/MAPK1/MAPK3/PLCB2/PLCB4/PLA2G4A/ITPR2	-1.25782361517517
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1271	89/9376	0.663089313024337	GNG4/NSF/PRKACA/GNGT2/GABRB3/GABRA2/ADCY3/ADCY4	-1.26460231257481
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1271	41/9376	0.539770873711884	GABRB3/GABRA2/GRIA3	-1.16947453952266
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1271	22/9376	0.33531220942708	ALDH3A2	-1.23598233274153
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1271	68/9376	0.542416809367335	AOX1/ALDH1A3/DGAT1/RDH12/RDH11	-1.49960968006614
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1271	23/9376	0.320733417712859	ARG2	-1.29154815678852
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1271	37/9376	0.398749654453824	GFPT2/AGXT2	-1.45106850905146
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1271	51/9376	0.433933447493868	PLA2G6/PLB1/PLA2G4A	-1.60512946082143
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1271	26/9376	0.283725715669067	HHEX	-1.44824531361688
NA	NA	hsa04382	Cornified envelope formation	20/1271	217/9376	0.67989572418394	S100A4/PCSK6/COL4A1/SLC27A4/PPP2R5C/KRT8/COL4A2/S100A16/COL7A1/KDSR/KRT7/LAMC2/JUP/KRT19/PPP2R5D/EPHX2/CAPN1/BLMH/SLC27A1/UGCG	-1.88920556675026
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1271	86/9376	0.514665251678773	PRKACA/GABRA2/PLCB2/P2RY1/PLCB4/ADCY4	-1.7904601480223
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/1271	55/9376	0.402374651312496	KDSR/CERS2/UGCG	-1.76019589869748
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	11/1271	138/9376	0.588011265806908	MT-CO3/COX4I1/MT-ATP8/NDUFV1/UQCRC1/ATP6V0E2/UQCRC2/ATP6V1E2/TCIRG1/NDUFS5/MT-ND4L	-1.93071339013603
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1271	29/9376	0.254374779565371	CALM1	-1.59244840761681
NA	NA	hsa04082	Neuroactive ligand signaling	17/1271	199/9376	0.630184755405667	GNG4/P2RX4/PRKACA/GNGT2/GABRB3/GABRA2/ADCY3/OGFR/POMC/PLCB2/GRIA3/P2RY1/PLCB4/TACR2/ADCY4/P2RX6/P2RY6	-2.08805957748708
NA	NA	hsa03272	Virion - Hepatitis viruses	2/1271	48/9376	0.307369525308156	CD9/IST1	-1.90506522631421
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1271	36/9376	0.204913016872104	DNA2	-1.89266765196957
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1271	66/9376	0.223541472951386	CYP1B1/SRD5A1	-2.50667075900925
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1271	143/9376	0.412691950064098	C1S/HLA-DRB5/HLA-DQB2/C2/RO60/IFNG/C6/HLA-DOB	-2.80249249588378
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/1271	183/9376	0.443418331592094	BMS1/GAR1/UTP18/POP5/UTP15/RPP25L/RPP38/GNL3L/WDR43/WDR3/PWP2	-3.01097893372541
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/1271	191/9376	0.386223487298207	CALM1/GNG4/FOSB/PRKACA/GNGT2/MAPK1/MAPK3/CAMKK1/HDAC3/SOS2	-3.39366736830489
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1271	370/9376	0.518374550789972	CGA/GZMA/CSH1/LHCGR/BDKRB1/P2RX4/AGTR1/PTGDR/C3AR1/GABRB3/C5AR1/GABRA2/S1PR4/S1PR3/FPR1/THRB/OGFR/POMC/GRIA3/AGT/P2RY1/TACR2/PTAFR/MC1R/P2RX6/P2RY6	-3.74305511254599
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1271	449/9376	0.115006860248932	CALM1/PRKACA/GRK2/ADCY3/SLC8A1/CAMK2D/SLC8A2	-7.61013237435436