category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/877	250/9376	2.09543443557583	ZFYVE27/SNX5/RABEP1/SNF8/VPS25/WASL/RAB4A/VPS35/ARFGAP3/EPN2/CHMP2B/RAB5B/SH3KBP1/STAMBP/ZFYVE16/VPS26B/WASHC5/WASHC4/ARPC4/WASHC3/DNM2/RAB11FIP2/AP2B1/PIP5K1C/AP2A1/GBF1/SNX4/CHMP2A/EHD1/SNX2/RAB11FIP1/AP2A2/CHMP4A/RAB7A/WASHC1/SPART/STAM2/STAM/DAB2/SNX1/EPS15L1/WASHC2C/EPS15/ARAP2/PIP5K1A/GRK4/MDM2/ACAP2/ASAP3	5.63920238803343
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/877	108/9376	2.57375733772541	UBE2I/CASC3/DDX39B/ACIN1/NUP58/NCBP1/KPNA2/POM121/NXF1/RNPS1/IPO9/XPO4/NMD3/NUP214/THOC6/CSE1L/UPF2/RANGAP1/UPF1/SEC13/TNPO3/XPO1/NUP37/SENP2/NUP153/SNUPN	5.28394335804955
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	33/877	169/9376	2.08759015740859	MAP2K1/VPS41/MAP1LC3A/WDR41/PRKACA/WDR45/CAMKK2/PRKACB/BAD/WIPI1/RRAS2/AMBRA1/MTMR3/PDPK1/RAF1/AKT1S1/ATG4B/OPTN/NBR1/AKT1/NRBF2/PPP2CB/RAB7A/GABARAPL1/ATG5/RAB1A/MLST8/PIK3C3/VPS11/RRAS/PIK3CB/MTMR14/MAP2K2	4.583012793716
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	31/877	157/9376	2.11096020742398	MAP2K1/RBL2/CAPN1/E2F3/HUS1/CAPN2/CDK4/RRAS2/PPP3CC/VDAC1/RAF1/CDK6/AKT1/RAD9A/SLC25A4/PPP3CB/SIRT1/MCU/TRPM7/ATR/TP53/TRAF3IP2/GADD45G/RAD50/RRAS/RAD1/NFATC3/PIK3CB/MAP2K2/MAPK11/MDM2	4.509287675747
Genetic Information Processing	Translation	hsa03010	Ribosome	39/877	222/9376	1.87814724644827	RPL13A/RPL3/RPS2/RPLP0/MRPS18B/RACK1/RPL18A/MRPS12/MRPS35/RPL26L1/MRPL27/MRPL36/MRPS7/MRPL11/RPL6/MRPS27/MRPL43/MRPS15/MRPL14/MRPS26/MRPS22/MRPL51/DAP3/MRPL24/MRPL37/MRPS31/MRPS30/MRPL18/MRPL38/MRPL40/RPL12/MRPS5/MRPS2/MRPS25/RPL10A/MRPS9/MRPL1/MRPL3/MRPL45	4.25343594917088
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/877	122/9376	2.19077705291886	ACTG1/MAP2K1/EP300/PRKACA/PRKACB/BAD/PDPK1/RAF1/AKT1/WNT4/MED1/THRA/ITGAV/PFKM/TP53/NCOA2/RCAN1/SLC2A1/NCOA3/PLCG1/RXRA/PIK3CB/MAP2K2/NCOR1/MDM2	4.2525276386545
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/877	204/9376	1.88664565027836	COL1A1/TIMP3/ACTG1/MAP2K1/COL1A2/ARHGEF1/PLAUR/FRS2/EZR/PRKACA/NUDT16L1/PPP1R12C/PRKACB/RRAS2/PDPK1/RAF1/TIAM1/DDX5/PPP1R12B/AKT1/WNT4/ITGAV/VEGFA/CASP3/TP53/SDC2/FZD3/RRAS/PLCG1/CD44/PTPN11/PIK3CB/MAP2K2/MAPK11/MDM2/DCN	4.11277232786328
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/877	77/9376	2.49919293932977	MAP2K1/STAT5B/E2F3/BAD/CDK4/CDKN1B/RAF1/CDK6/AKT1/IKBKB/TP53/GADD45G/CTBP1/PTPN11/PIK3CB/MAP2K2/MDM2/CRKL	4.24312950550398
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	18/877	78/9376	2.46715200421016	INPP4B/IMPA1/PPIP5K2/MTMR3/ITPK1/IP6K1/INPP4A/PIP5K1C/PI4KB/PI4KA/PIK3C3/PLCG1/IPMK/INPP5B/PIK3CB/PIP5K1A/MTMR14/PI4K2A	4.17954650512403
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/877	30/9376	3.56366400608134	IDH3G/SUCLG1/SUCLA2/SDHB/MDH1/ACLY/SUCLG2/IDH1/ACO1/DLST	4.51762694657975
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/877	308/9376	1.66612862621985	TGM2/MT-CO3/PSMC2/PSMC3/DCTN3/EP300/CREB3L2/NDUFV1/PSMD4/MT-ATP8/SDHB/NDUFA5/DCTN1/NDUFS1/NDUFB1/POLR2A/WIPI1/NDUFV3/AMBRA1/TUBA1C/PSMA5/SOD2/NDUFA9/VDAC1/POLR2B/NDUFA10/CREB3/AP2B1/AP2A1/SLC25A4/MAP2K7/NRBF2/AP2A2/IFT57/DCTN2/CASP3/TP53/PSMD14/PIK3C3/POLR2J3/PSMD12/RCOR1/ATP5F1A/PPIF/GPX8/ATP5MC3/ACTR1B/DCTN5	3.81838064722339
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/877	368/9376	1.59783848098756	MT-CO3/ACTG1/ANXA7/PSMC2/PSMC3/MAP1LC3A/DCTN3/NUP58/NCBP1/WDR41/NDUFV1/PSMD4/MT-ATP8/CHMP2B/POM121/SDHB/NDUFA5/NXF1/DCTN1/NDUFS1/NDUFB1/BAD/WIPI1/NDUFV3/AMBRA1/TUBA1C/PSMA5/NDUFA9/PPP3CC/VDAC1/OPTN/NUP214/NDUFA10/UBQLN2/NRBF2/PPP3CB/MCU/TOMM40/DCTN2/CASP3/SEC13/SPG11/TP53/PSMD14/RAB1A/NUP37/PIK3C3/NUP153/PSMD12/ATP5F1A/GPX8/ATP5MC3/MAPK11/ACTR1B/DCTN5	3.75833169594978
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/877	116/9376	2.11976565878976	IDH3G/SUCLG1/SUCLA2/SDHB/H6PD/ACOX1/MDH1/GLUD1/PFKM/SUCLG2/IDH1/ACOX3/ACO1/ECHS1/GOT1/DLST/TKT/ADPGK/ADH5/PRPS1/ENO1/MCEE/ME1	3.89809272748716
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/877	248/9376	1.72435355132968	ACTG1/MAP2K1/CASP7/VPS41/DCTN3/STX10/CASP4/WASL/PLEKHM2/M6PR/PAK3/RAB5B/DCTN1/TUBA1C/TXN2/RAF1/ARPC4/DNM2/AKT1/ARL8B/DYNLT3/RAB9A/CSE1L/IKBKB/MAP2K7/RAB7A/DCTN2/CASP3/TAB3/TRADD/PIK3C3/VPS11/RRAS/RIPK1/CYFIP1/PIK3CB/MAP2K2/MAPK11/ACTR1B/DCTN5	3.71355737890255
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	23/877	117/9376	2.10164800358643	ACTG1/SMARCB1/SMARCA1/SMARCE1/POLE3/EP400/BAZ1B/ACTL6A/ING3/MTA3/BICRAL/SMARCC2/INO80E/SMARCC1/TRRAP/UCHL5/MBD3/GATAD2B/DMAP1/ACTR6/RBBP7/DPF3/CHD3	3.85172489735843
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	21/877	103/9376	2.17971681925363	RNMT/CASC3/DDX39B/ACIN1/NCBP1/WDR82/FIP1L1/NXF1/MSI2/RNPS1/PCF11/UPF2/GSPT1/SMG6/UPF1/PPP2CB/CPSF7/CPSF2/SMG1/SYMPK/CPSF4	3.86712111416779
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/877	70/9376	2.44365531845577	MAP2K1/EP300/PAK3/BAD/FLCN/RAF1/EGLN1/AKT1/VEGFA/SLC2A1/ARNT/PTPN11/PIK3CB/MAP2K2/TFE3/CRKL	3.89432803688268
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/877	174/9376	1.84327448590414	SAR1A/SEC23A/BAG1/UBE2G1/GANAB/EDEM1/DNAJB12/AMFR/SEL1L/SEC61A1/UBXN6/CAPN1/UBE2J2/DNAJC5/CAPN2/SEC24D/OS9/CKAP4/DDOST/SEC24A/UBQLN2/MAP2K7/MBTPS2/SEC13/EDEM2/DNAJC3/SEC23B/MAN1B1/UBXN4/PREB	3.60664992791925
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/877	250/9376	1.66779475484607	CTSK/IDS/HGSNAT/HEXA/VPS41/VPS35/OSBP/M6PR/WDR7/VPS26B/AP3D1/DMXL1/AKT1S1/DTNBP1/AP2B1/ARL8B/AP2A1/AP2A2/GGA2/DNASE2/RAB7A/SPG11/NAGLU/OSBPL5/ATP6V0A1/MLST8/SLC15A3/VPS11/GAA/IDUA/AP1B1/SORT1/BLOC1S5/BORCS5/CLCN7/BLOC1S4/TFE3/ZFYVE26/MAN2B1	3.43775004139302
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/877	31/9376	3.10383639239342	SRPRB/TMEM208/SEC61A1/SGTA/SRP54/SRP72/SRPRA/UBL4A/SRP68	3.76881376682149
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/877	32/9376	3.00684150513113	SUCLG1/SUCLA2/ACOX1/ECHDC1/SUCLG2/BCKDHB/ACOX3/ECHS1/MCEE	3.65277707907542
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/877	33/9376	2.91572509588473	STX18/STX16/VTI1B/STX4/STX11/BET1/STX8/STX5/SEC22B	3.54118408961286
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/877	73/9376	2.19677918183096	MAP2K1/STAT5B/E2F3/BAD/CDK4/PDPK1/RAF1/CDK6/AKT1/TP53/GADD45G/PLCG1/RXRA/PIK3CB/MAP2K2	3.29735317107765
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/877	142/9376	1.80692822843561	UBE2I/DDB1/UBE2G1/UBE2F/UBE2Q2/CUL5/UBE2S/UBE2J2/SAE1/UBE2R2/UBA2/MID1/UBE2K/TRIM37/MGRN1/PIAS1/PIAS4/FBXW8/UBE2O/COP1/FZR1/HERC2/CUL4B/MDM2	3.11233019255215
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/877	105/9376	1.93456046044415	CSNK2A2/MAP1LC3A/AMFR/MFN1/RAB5B/RRAS2/AMBRA1/OPTN/NBR1/RHOT1/TOMM40/RAB7A/GABARAPL1/TP53/RRAS/MTX1/TOMM70/TFE3/MUL1	3.09342992261742
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/877	98/9376	1.96365159518768	INPP4B/IMPA1/PPIP5K2/MTMR3/ITPK1/IP6K1/INPP4A/PIP5K1C/PI4KB/PI4KA/PIK3C3/PLCG1/IPMK/INPP5B/PIK3CB/PIP5K1A/MTMR14/PI4K2A	3.08040215589304
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/877	48/9376	2.45001900418092	ALDH9A1/HADHB/HIBADH/IVD/HMGCS1/AUH/BCKDHB/ECHS1/BCAT2/MCEE/ACAA2	3.23520320721433
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/877	99/9376	1.94381673058982	MAP2K1/PRKACA/E2F3/PRKACB/BAD/CDK4/CDKN1B/RAF1/AKT1/MED1/TP53/ADCY9/NCOA3/PIK3CB/MAP2K2/NCOR1/MAPK11/MDM2	3.03251537102888
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/877	388/9376	1.43281336326982	APOE/MT-CO3/PSMC2/CSNK2A2/MAP2K1/CASP7/PSMC3/NDUFV1/PSMD4/MT-ATP8/CAPN1/SDHB/NDUFA5/NDUFS1/NDUFB1/BAD/CAPN2/WIPI1/NDUFV3/AMBRA1/TUBA1C/PSMA5/NDUFA9/PPP3CC/VDAC1/RAF1/NDUFA10/AKT1/SLC25A4/WNT4/IKBKB/MAP2K7/NRBF2/PPP3CB/MCU/CASP3/PSMD14/SLC39A6/BACE1/PIK3C3/SLC39A11/FZD3/SLC39A14/PSMD12/ATP5F1A/PPIF/ATP5MC3/PIK3CB/SLC39A13/RTN3/MAP2K2/ADAM17	2.79696165530974
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/877	78/9376	2.05596000350846	BTG3/LSM4/CNOT1/DDX6/DCP2/EXOSC1/PARN/PNPT1/PFKM/XRN1/MPHOSPH6/CNOT6/CNOT3/CNOT6L/ENO1	3.00816406858302
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/877	93/9376	1.95426735817364	CKS2/LAMA2/E2F3/CDK4/CKS1B/CDKN1B/CDK6/AKT1/TRAF3/IKBKB/ITGAV/CASP3/TP53/GADD45G/RXRA/PIK3CB/LAMC1	2.97076903040679
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/877	44/9376	2.42977091323728	CREB3L2/PRKACA/STX4/RAB5B/PRKACB/DCTN1/CREB3/DCTN2/ADCY9/DCTN5	3.0535634675608
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	34/877	235/9376	1.54678182391615	MT-CO3/ACTG1/SMARCB1/FRS2/SMARCE1/CREB3L2/PRKACA/NDUFV1/MT-ATP8/SDHB/ACTL6A/PRKACB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/NDUFA9/CNR1/SMARCC2/AKT1S1/NDUFA10/CREB3/SMARCC1/NDUFAF6/MLST8/SLC25A29/ADCY9/DPF3/ATP5F1A/ATP5MC3/KDM3B/COX15/RPS6KA1/MAPK11	2.72679611317729
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	33/877	227/9376	1.55419707754208	MT-CO3/MAP2K1/NDUFV1/MT-ATP8/SDHB/NDUFA5/NDUFS1/NDUFB1/BAD/NDUFV3/PDPK1/SOD2/NDUFA9/VDAC1/RAF1/CYBA/NDUFA10/AKT1/CBR1/SLC25A4/IKBKB/MAP2K7/VEGFA/GSTM3/ARNT/ATP5F1A/PPIF/ATP5MC3/PTPN11/PIK3CB/HMOX1/MAP2K2/MAPK11	2.71513773955129
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/877	60/9376	2.1381984036488	MAP2K1/BAD/PPP3CC/RAF1/AKT1/PPP3CB/VEGFA/HSPB1/PLCG1/PIK3CB/MAP2K2/MAPK11	2.84105981719235
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	38/877	275/9376	1.47730071524826	MT-CO3/PSMC2/CSNK2A2/PSMC3/CREB3L2/PRKACA/NDUFV1/PSMD4/MT-ATP8/SDHB/STIP1/PRKACB/NDUFA5/NDUFS1/NDUFB1/BAD/NDUFV3/TUBA1C/PSMA5/NDUFA9/PPP3CC/VDAC1/CYBA/NDUFA10/CREB3/SLC25A4/PPP3CB/MCU/CASP3/PSMD14/PSMD12/ATP5F1A/PPIF/ATP5MC3/CCL5/PIK3CB/MAPK11/LAMC1	2.58056852054537
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/877	83/9376	1.93210699124892	GSTK1/SOD2/ACOX1/CROT/GNPAT/CRAT/IDH1/ACOT8/ACOX3/PHYH/PMVK/PEX2/PEX26/PEX3/PEX11B	2.73985994482947
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/877	268/9376	1.47599516669787	MT-CO3/PSMC2/UBE2G1/PSMC3/PRKACA/NDUFV1/PSMD4/MT-ATP8/MFN1/SDHB/UBE2J2/PRKACB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/TUBA1C/PSMA5/NDUFA9/TXN2/VDAC1/NDUFA10/SLC25A4/MCU/CASP3/TP53/PSMD14/SLC39A6/SLC39A11/PLCG1/MAOB/SLC39A14/PSMD12/ATP5F1A/PPIF/ATP5MC3/SLC39A13	2.53956860288359
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/877	21/9376	3.05456914806972	B3GAT3/B4GALT7/CHST3/CHST7/CHPF/CHST14	3.0276804325035
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/877	480/9376	1.3363740022805	MT-CO3/PSMC2/CSNK2A2/MAP2K1/UBE2G1/CASP7/PSMC3/MAP1LC3A/DCTN3/WDR41/NDUFV1/PSMD4/MT-ATP8/CHMP2B/MFN1/CAPN1/SDHB/UBE2J2/NDUFA5/DCTN1/NDUFS1/NDUFB1/BAD/CAPN2/WIPI1/NDUFV3/AMBRA1/TUBA1C/PSMA5/NDUFA9/PPP3CC/VDAC1/RAF1/OPTN/NDUFA10/SLC25A4/WNT4/MAP2K7/NRBF2/PPP3CB/IFT57/MCU/TOMM40/DCTN2/CASP3/SPG11/PSMD14/RAB1A/PIK3C3/FZD3/PLCG1/PSMD12/ATP5F1A/PPIF/GPX8/ATP5MC3/MAP2K2/MAPK11/ACTR1B/DCTN5	2.43022886253193
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/877	227/9376	1.50710019640444	MAP2K1/CXCL12/ARHGEF1/IRF3/CREB3L2/PRKACA/E2F3/PRKACB/CDK4/PPP3CC/RAF1/CDK6/AKT1/CREB3/IKBKB/PPP3CB/ITGAV/VEGFA/CASP3/TP53/TRADD/ADCY9/RIPK1/NFATC3/CCL5/PIK3CB/MAP2K2/MAPK11/AKAP13/MDM2/ARHGEF11/CRKL	2.4843993892895
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/877	203/9376	1.52728457403486	COL1A1/COL6A3/ACTG1/ZYX/MAP2K1/COL1A2/COL6A1/LAMA2/PAK3/PPP1R12C/ILK/BAD/CAPN2/PDPK1/RAF1/PPP1R12B/AKT1/PIP5K1C/ARHGAP35/ITGAV/VEGFA/TNC/ARHGAP5/PIK3CB/PIP5K1A/LAMC1/VEGFB/PARVG/CRKL	2.4397139446198
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/877	120/9376	1.69274040288864	MAP2K1/FRS2/BAD/PDPK1/RAF1/AKT1/IKBKB/MAP2K7/TP53/MAGED1/KIDINS220/PLCG1/SORT1/PTPN11/PIK3CB/MAP2K2/RPS6KA1/MAPK11/CRKL	2.4533018603583
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/877	205/9376	1.5123842367272	PSMC2/IRF3/PSMC3/PSMD4/E2F3/CDK4/CDKN1B/CDK6/AKT1/TRAF3/SNW1/VIM/IKBKB/MAP2K7/NCOR2/SAP30/CASP3/TP53/PSMD14/HLA-DPB1/TRADD/GADD45G/SAP30L/RIPK1/PSMD12/CD44/PIK3CB/MAPK11/MDM2	2.38268079586438
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/877	73/9376	1.90387529092017	MAP2K1/FGF10/E2F3/BAD/CDK4/RAF1/CDK6/AKT1/TP53/GADD45G/PIK3CB/MAP2K2/MDM2	2.49034751107102
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/877	44/9376	2.18679382191355	HEXA/MGAT2/B4GALT1/DDOST/MAN1B1/ALG9/ALG1/B4GALT2/MGAT4C	2.53463699993501
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/877	90/9376	1.78183200304067	CREB3L2/PRKACA/CAMKK2/PRKACB/SOD2/AKT1S1/AKT1/CREB3/EIF4E2/SIRT1/EHMT1/TP53/ATG5/ADCY9/PIK3CB	2.39398750265397
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/877	76/9376	1.82872231891016	MAP2K1/E2F3/CDK4/RAF1/CDK6/AKT1/CAMK1/TP53/GADD45G/PLCG1/PIK3CB/MAP2K2/MDM2	2.33010706898359
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/877	77/9376	1.80497267840483	MAP2K1/E2F3/BAD/CDK4/RAF1/CDK6/AKT1/IKBKB/VEGFA/TP53/ARHGEF6/GADD45G/PIK3CB	2.27829469660596
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/877	32/9376	2.33865450399088	B4GALT1/PFKM/UGP2/GAA/PGM1/GALK1/B4GALT2	2.43656834706508
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/877	32/9376	2.33865450399088	WIPI1/ATG4B/PPP2CB/GABARAPL1/ATG5/MLST8/PIK3C3	2.43656834706508
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/877	110/9376	1.65224422100135	MAP2K1/EP300/CDKN1B/MKNK1/EGLN1/AKT1/EIF4E2/PFKM/VEGFA/PFKFB3/SLC2A1/ARNT/PLCG1/PIK3CB/HMOX1/ENO1/MAP2K2	2.21035461550482
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/877	54/9376	1.97981333671185	ADI1/MAT2B/DNMT1/AMD1/MDH1/MAT2A/KYAT3/MTAP/GOT1/BCAT2	2.31946165610449
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/877	19/9376	2.81341895216948	IDS/HGSNAT/HEXA/NAGLU/IDUA	2.54160558563776
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/877	119/9376	1.61712484309573	MAP2K1/CASP7/CREB3L2/AKT1/CREB3/CASP10/TRAF3/IKBKB/IL15/MAP2K7/CASP3/TAB3/TRADD/RIPK1/CCL5/PIK3CB/MAPK11/ADAM17	2.17627061924915
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/877	224/9376	1.43182928815768	MAP2K1/EP300/CREB3L2/PRKACA/STAT5B/E2F3/PRKACB/CDK4/PPP3CC/VDAC1/AKT1/CREB3/SLC25A4/IKBKB/IL15/TCF3/TRRAP/PPP3CB/CRTC1/ATR/TP53/HLA-DPB1/XPO1/SLC2A1/ADCY9/MAD1L1/NFATC3/PIK3CB/IL15RA/MAP2K2	2.1012591522132
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/877	137/9376	1.56072876178745	ACTG1/CTSK/MAP2K1/CASP7/CAPN1/BAD/CAPN2/TUBA1C/PDPK1/RAF1/AKT1/CASP10/IKBKB/CASP3/TP53/TRADD/GADD45G/RIPK1/PIK3CB/MAP2K2	2.1237439440869
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/877	33/9376	2.26778618568812	IDH3G/IDH1/BCKDHB/ACO1/GOT1/DLST/BCAT2	2.34348042912515
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/877	63/9376	1.86668114604261	ALDH9A1/SMYD2/PLOD3/EHMT1/EZH1/SETD2/ECHS1/DLST/NSD1/CAMKMT/SETD1B	2.21710541386993
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/877	63/9376	1.86668114604261	DDB1/POLE3/POLR2M/RFC1/POLR2A/CDK7/POLR2B/POLD2/POLR2J3/ERCC3/CUL4B	2.21710541386993
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/877	71/9376	1.80692822843561	MAP2K1/SLC1A5/RAF1/AKT1/SLC16A3/PFKM/IDH1/SCO2/TP53/SLC2A1/PIK3CB/MAP2K2	2.19233750919962
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/877	138/9376	1.54941913307884	ACTG1/MAP2K1/ARHGEF1/IRF3/WASL/ARPC4/AKT1/PIP5K1C/IKBKB/MAP2K7/BAIAP2/PLCG1/NFATC3/PIK3CB/PIP5K1A/MAP2K2/RPS6KA1/MAPK11/LIMK1/CRKL	2.08860283810894
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/877	173/9376	1.48314340137489	ACTG1/MAP2K1/IRF3/EP300/KPNA2/NXF1/CDK4/VDAC1/RAF1/CDK6/AKT1/TRAF3/SLC25A4/IKBKB/CASP3/DNAJC3/HLA-DPB1/TRADD/XPO1/CCL5/PIK3CB/TRIM25/MAP2K2/CPSF4	2.06032585853625
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/877	41/9376	2.086047223072	MAP2K1/E2F3/CDK4/RAF1/VEGFA/TP53/MAP2K2/MDM2	2.23864380155973
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/877	157/9376	1.4981007923654	CD47/STAB1/MAP2K1/CASP7/VPS41/RAB5B/SIRT1/ITGAV/RAB7A/CASP3/SLC2A1/VPS11/ARNT/PBX1/RXRA/NFATC3/PTPN11/MAP2K2/MAPK11/ADAM17/GAS6/CRKL	2.02174636794705
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/877	106/9376	1.61373464426325	ZEB1/MAP2K1/EP300/CREB3L2/E2F3/BAD/PDPK1/CDKN1B/RAF1/AKT1/CREB3/IKBKB/TP53/PIK3CB/MAP2K2/MDM2	2.04124542783553
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/877	42/9376	2.03637943204648	SAT2/MAP1LC3A/FTL/SLC40A1/TP53/ATG5/SLC39A14/HMOX1	2.16227562491754
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/877	133/9376	1.52728457403486	MAP2K1/EP300/RBL2/PDPK1/SOD2/CDKN1B/RAF1/AKT1/SGK3/IKBKB/SIRT1/GABARAPL1/CCNG2/GADD45G/PIK3CB/MAP2K2/MAPK11/HOMER3/MDM2	1.96727888318052
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/877	232/9376	1.38245586442811	TMSB4X/ACTG1/MAP2K1/CXCL12/ARHGEF1/WASL/FGF10/EZR/PAK3/PPP1R12C/RRAS2/RAF1/ARPC4/TIAM1/PPP1R12B/AKT1/PIP5K1C/ARHGAP35/ENAH/ITGAV/BAIAP2/WASF1/ARHGEF6/RRAS/CYFIP1/PIK3CB/PIP5K1A/MAP2K2/LIMK1/CRKL	1.89477972365519
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/877	196/9376	1.41819281874666	MAP2K1/IRF3/MAP1LC3A/EP300/E2F3/CDK4/PPP3CC/RAF1/C3/CDK6/AKT1/TRAF3/IKBKB/MAP2K7/PPP3CB/VEGFA/CASP3/TP53/TRADD/RCAN1/PIK3C3/PLCG1/NFATC3/PIK3CB/MAP2K2/MAPK11	1.90057401026755
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/877	43/9376	1.9890217708361	ALDH9A1/HADHB/ACOX1/ACADVL/ACOX3/ECHS1/ADH5/ACAA2	2.0880022712791
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/877	75/9376	1.71055872291904	IDH3G/MAT2B/ASL/MAT2A/PFKM/IDH1/ACO1/GOT1/TKT/BCAT2/PRPS1/ENO1	1.98457403520558
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/877	75/9376	1.71055872291904	REV3L/BAD/PDPK1/TOP2B/AKT1/GSTM3/CASP3/TP53/MSH3/MSH2/PIK3CB/MDM2	1.98457403520558
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/877	170/9376	1.44642833188007	ACTG1/MAP2K1/SMARCB1/SMARCE1/ACTL6A/E2F3/BAD/CDK4/SMARCC2/RAF1/CDK6/AKT1/SMARCC1/WNT4/GSTM3/TP53/GADD45G/FZD3/DPF3/PLCG1/PIK3CB/HMOX1/MAP2K2	1.88687115032216
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/877	59/9376	1.81203254546509	MAP2K1/ILK/BAD/PDPK1/RAF1/AKT1/TP53/GADD45G/PIK3CB/MAP2K2	2.00984661172036
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/877	144/9376	1.48486000253389	ALDH9A1/IRF3/CAMKK2/LPIN1/ACOX1/C3/LPIN2/ACADVL/AKT1/TRAF3/IKBKB/MAP2K7/SIRT1/CASP3/ACOX3/TAB3/TRADD/RIPK1/ADH5/MAPK11	1.88343756364553
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/877	101/9376	1.58777109181842	COL3A1/COL1A1/COL1A2/STAT5B/PIM1/CDK4/CDKN1B/AKT1/F3/VEGFA/CASP3/PLCG1/PIK3CB/MAPK11/VEGFB	1.90771489456084
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/877	44/9376	1.94381673058982	GTF2F2/TAF13/TAF12/TAF7/CDK7/GTF2F1/GTF2A1/ERCC3	2.01571053230922
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/877	200/9376	1.38982896237172	ACTG1/CASP7/ARHGEF1/CASP4/WASL/EZR/MYO5A/PAK3/SEC24D/TUBA1C/CLDN4/SEC24A/ARPC4/IKBKB/BAIAP2/CASP3/TAB3/ABCF2/RAB1A/WASF1/TRADD/RIPK1/CYFIP1/PTPN11/MAPK11/ARHGEF11	1.79004487102666
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/877	37/9376	2.02262011155968	NAGK/NANS/UGP2/GFPT1/PGM1/GALK1/GALK2	2.00201129888798
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	40/877	333/9376	1.28420324543472	COL1A1/COL6A3/MAP2K1/COL1A2/IRF3/COL6A1/EP300/CREB3L2/LAMA2/MAML1/RBL2/PRKACA/PRKACB/TADA3/BAD/CDK4/CDKN1B/RAF1/CDK6/AKT1/CREB3/TRAF3/WNT4/IKBKB/ITGAV/PPP2CB/VEGFA/ATR/CASP3/RFNG/TP53/TNC/ATP6V0A1/TRADD/FZD3/PIK3CB/MAP2K2/NFX1/LAMC1/MDM2	1.69627555923647
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/877	38/9376	1.96939326651863	HEXA/NAGK/UGP2/GFPT1/PGM1/GALK1/GALK2	1.92338569867541
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/877	62/9376	1.72435355132968	PRKACA/EIF4EBP2/PRKACB/SOD2/AKT1S1/AKT1/SIRT1/ATG5/ADCY9/PIK3CB	1.83814531609216
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/877	46/9376	1.85930295969461	PSMC2/PSMC3/PSMD4/PSMA5/PSME2/PSMB8/PSMD14/PSMD12	1.87666140231708
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	17/877	122/9376	1.48972839598482	MAP2K1/PAK3/CDK4/PDPK1/PPP3CC/RAF1/AKT1/IKBKB/MAP2K7/PPP3CB/PPP2CB/PLCG1/NFATC3/PTPN11/PIK3CB/MAP2K2/MAPK11	1.74892817614726
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/877	122/9376	1.48972839598482	MAP2K1/EP300/CREB3L2/PRKACA/STAT5B/PRKACB/RAF1/CSH1/AKT1/CREB3/SOCS2/ADCY9/PLCG1/PIK3CB/MAP2K2/MAPK11/CRKL	1.74892817614726
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/877	158/9376	1.42095463533623	MAP2K1/CLIP1/PDPK1/LPIN1/WDR59/FLCN/RAF1/AKT1S1/LPIN2/AKT1/EIF4E2/WNT4/IKBKB/SEC13/MLST8/RICTOR/FZD3/PIK3CB/MAP2K2/RPS6KA1/MIOS	1.7141428359748
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/877	31/9376	2.06922426159562	DERA/H6PD/PFKM/TKT/PGM1/PRPS1	1.91540897927748
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/877	71/9376	1.65635087606597	MAP2K1/CGA/STAT5B/SOCS6/RAF1/AKT1/SOCS2/PRLR/PIK3CB/MAP2K2/MAPK11	1.78323498185848
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	26/877	205/9376	1.3559306949968	COL3A1/MT-CO3/COL1A1/COL1A2/NDUFV1/MT-ATP8/SDHB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/NDUFA9/VDAC1/CYBA/MPC1/NDUFA10/AKT1/SLC25A4/GFPT1/SLC2A1/PDK4/ATP5F1A/PPIF/ATP5MC3/PIK3CB/MAPK11	1.65514309543262
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	31/877	253/9376	1.30996344887575	ACTG1/IRF3/MAP1LC3A/TNIP1/CASP4/WASL/CAPN1/ILK/CAPN2/WIPI1/VDAC1/C3/AKT1S1/ARPC4/AKT1/IKBKB/TAB3/TP53/ATG5/WASF1/TRADD/PIK3C3/RIPK1/PLCG1/CD44/CCL5/PIK3CB/MAPK11/RNF31/MDM2/CRKL	1.60547455895528
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/877	56/9376	1.71819514578922	GANAB/MGAT2/B4GALT1/DDOST/MAN1B1/ALG9/ALG1/B4GALT2/MGAT4C	1.7315300901887
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/877	90/9376	1.54425440263525	CSNK2A2/MAP2K1/PPP3CC/RAF1/AKT1/IKBKB/PPP3CB/PLCG1/NFATC3/PTPN11/PIK3CB/MAP2K2/MAPK11	1.66651944804747
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/877	73/9376	1.61097140000937	SMARCB1/EP300/SAMHD1/CCNT1/CCNT2/CHMP4A/CPSF7/TNPO3/SUPT5H/XPO1/NUP153	1.68334185106439
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/877	144/9376	1.4106170024072	RORA/PSMC2/PSMC3/PSMD4/ATXN10/WIPI1/AMBRA1/PSMA5/VDAC1/AKT1/NOP56/SLC25A4/NRBF2/MCU/PSMD14/PIK3C3/PSMD12/PPIF/PIK3CB	1.59504080056837
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/877	163/9376	1.37736706983512	DDB1/MAP2K1/IRF3/EP300/CREB3L2/STAT5B/E2F3/BAD/RAF1/AKT1/CREB3/CASP10/TRAF3/IKBKB/MAP2K7/CASP3/TP53/NFATC3/PIK3CB/MAP2K2/MAPK11	1.56120087690626
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/877	49/9376	1.74546808461127	GALNT13/PLOD3/GALNT1/B4GALT1/GALNT11/RFNG/XXYLT1/B4GALT2	1.68057394775298
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/877	75/9376	1.56801216267579	CDK4/CDK6/CD82/MDM4/ATR/CASP3/TP53/CCNG2/GADD45G/COP1/MDM2	1.58644479811104
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/877	156/9376	1.37064000233898	MAP2K1/IRF3/E2F3/BAD/CDK4/CLDN4/RAF1/CDK6/AKT1/TRAF3/IKBKB/PPP2CB/CASP3/TP53/TRADD/PIAS1/RIPK1/RXRA/PIK3CB/MAP2K2	1.4995144281617
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/877	50/9376	1.71055872291904	ALDH9A1/SAT2/AMD1/OAT/P4HA2/GOT1/MAOB/CKB	1.61822457460299
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/877	34/9376	1.88664565027836	POLR2M/POLR2A/POLR2B/CRCP/POLR2J3/POLR1A	1.66368513091503
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/877	12/9376	2.672748004561	GGCX/VKORC1L1/COQ4	1.86248147276892
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/877	85/9376	1.50931652022268	DTYMK/DCTPP1/NTPCR/ADK/NT5C3B/ADSL/GMPS/UCKL1/NT5C/DCK/ASMTL/ADA	1.51519146843024
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/877	130/9376	1.39805280238576	COL3A1/COL1A1/MAP2K1/COL1A2/CREB3L2/PRKACA/PRKACB/RAF1/AKT1/CREB3/MAP2K7/VEGFA/ADCY9/PIK3CB/MAP2K2/MAPK11/VEGFB	1.46803678403543
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/877	214/9376	1.29890557231002	DDB1/MAP2K1/IRF3/CUL5/PAK3/BAD/PPP3CC/RAF1/AKT1/SAMHD1/IKBKB/MAP2K7/PPP3CB/ATR/CASP3/TRADD/RIPK1/PLCG1/AP1B1/NFATC3/PIK3CB/MAP2K2/MAPK11/LIMK1/CUL4B/CRKL	1.42084686905111
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/877	51/9376	1.67701835580298	ACTG1/PRKACA/SEC61A1/PRKACB/ATP6V0A1/ADCY9/KDELR3/PLCG1	1.55726539087419
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	20/877	158/9376	1.35329012889165	EP300/RBL2/MAU2/E2F3/CDK4/WAPL/TFDP2/CDKN1B/SMC3/CDK7/CDK6/SMC1A/PPP2CB/ATR/TP53/GADD45G/PDS5B/MAD1L1/FZR1/MDM2	1.43861046446614
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/877	205/9376	1.30377951442	MRPS18B/DDB1/IRF3/EP300/CREB3L2/RBL2/PRKACA/STAT5B/PRKACB/BAD/CDK4/CDKN1B/C3/CDK6/CREB3/TRAF3/SNW1/CASP3/GTF2A1/TP53/TRADD/MAD1L1/PIK3CB/HDAC4/MDM2	1.41263052862203
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/877	86/9376	1.49176632812707	MAP2K1/STAT5B/PAK3/BAD/CDKN1B/RAF1/AKT1/MAP2K7/PLCG1/PIK3CB/MAP2K2/CRKL	1.47164031825469
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/877	69/9376	1.54941913307884	MAP2K1/PDPK1/RAF1/AKT1/MAP2K7/PLCG1/PIK3CB/MAP2K2/MAPK11/FCER1G	1.4713804724826
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/877	44/9376	1.70083963926609	POLE3/RFC1/TDG/UNG/POLD2/PARG/LIG3	1.49678406468343
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/877	115/9376	1.39447721977096	OXSR1/MAP2K1/ARHGEF1/CREB3L2/PRKACA/PRKACB/NACA/RAF1/CREB3/PDE4B/ADCY9/RXRA/MMP16/AKAP13/ARHGEF11	1.36723581729403
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/877	53/9376	1.61373464426325	PRKACA/PRKACB/DNM2/AP2B1/AP2A1/AP2A2/ADCY9/SLC8A1	1.43926993043053
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/877	98/9376	1.41819281874666	MAP2K1/RAF1/ARPC4/DNM2/AKT1/PIP5K1C/WASF1/PLCG1/PIK3CB/PIP5K1A/LIMK1/ASAP3/CRKL	1.33679232917712
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/877	72/9376	1.48486000253389	IRF3/AZI2/CASP10/TRAF3/IKBKB/ATG5/TRADD/RIPK1/TRIM25/MAPK11	1.32662835952594
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/877	136/9376	1.3363740022805	RACK1/CSNK2A2/IRF3/STAT5B/BAD/CDK4/EIF3H/CDKN1B/CDK6/AKT1/TRAF3/RAB9A/IKBKB/CASP3/TP53/TRADD/PIK3CB	1.26927992549622
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/877	14/9376	2.29092686105229	CHST2/B4GALT1/B4GALT2	1.55268321159453
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/877	56/9376	1.52728457403486	CSNK1G2/PRKACA/CSNK1D/PRKACB/GAS1/MGRN1/DISP1/CSNK1G1	1.27125491085072
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/877	83/9376	1.41687846024921	PHC2/USP16/EP300/FOXK2/RNF2/PCGF6/EZH1/RBBP7/AEBP2/SCMH1/PHC3	1.22538357272547
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/877	23/9376	1.85930295969461	B4GALT1/B3GALNT2/RXYLT1/B4GALT2	1.32536738372732
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/877	23/9376	1.85930295969461	RFC1/MSH3/MSH2/POLD2	1.32536738372732
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/877	67/9376	1.43610340543576	MAP2K1/EP300/PRKACA/PRKACB/PPP3CC/RAF1/PPP3CB/MAP2K2/RPS6KA1	1.15073913864637
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/877	105/9376	1.32364663083021	RRAS2/PPP3CC/RAF1/AKT1/IKBKB/PPP3CB/RRAS/NFATC3/PTPN11/PIK3CB/MAPK11/FCER1G/MDM2	1.07128239909558
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/877	68/9376	1.41498423770877	MAP2K1/STAT5B/PIM1/BAD/RAF1/AKT1/IKBKB/PIK3CB/MAP2K2	1.10321305020362
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/877	59/9376	1.44962603637207	DTYMK/DCTPP1/NT5C3B/UCKL1/NT5C/DCK/ASMTL/CDADC1	1.11286101867516
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/877	59/9376	1.44962603637207	PRKACA/CGA/PRKACB/AKT1/ABHD5/ADCY9/PLAAT3/PIK3CB	1.11286101867516
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/877	87/9376	1.35173462299637	MAP2K1/BAD/RAF1/AKT1/CASP3/TP53/MSH3/MSH2/GADD45G/PIK3CB/MAP2K2	1.05874600676758
NA	NA	hsa04518	Integrin signaling	18/877	154/9376	1.24959646966488	COL1A1/COL6A3/ACTG1/COL1A2/COL6A1/LAMA2/ILK/ICAM3/C3/AKT1/ITGAV/VEGFA/TNC/ARHGEF6/PIK3CB/LAMC1/VEGFB/PARVG	1.00320054646862
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/877	154/9376	1.24959646966488	ACTG1/MYL6B/MAP2K1/PRKACA/CAMKK2/PPP1R12C/PRKACB/CACNB2/PPP3CC/RAF1/PPP1R12B/CAMK1/PPP3CB/EEF2/RCAN1/ADCY9/NFATC3/MAP2K2	1.00320054646862
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/877	42/9376	1.52728457403486	ALDH9A1/KYAT3/ECHS1/DLST/AFMID/MAOB	1.10011309234422
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	21/877	184/9376	1.22016756729959	SEMA5A/PLXNB2/CXCL12/PAK3/ILK/RASA1/PDPK1/PPP3CC/RAF1/WNT4/PPP3CB/ENAH/FZD3/RRAS/PLCG1/TRPC4/NFATC3/PTPN11/PIK3CB/LIMK1/LRIG2	0.968854961709218
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/877	17/9376	1.88664565027836	PAPSS1/SEPHS2/KYAT3	1.17533412333272
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/877	80/9376	1.3363740022805	MAP2K1/BAD/RAF1/AKT1/EIF4E2/VEGFA/PLCG1/PIK3CB/MAP2K2/GAS6	0.970556625947913
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/877	138/9376	1.23953530646307	MAP2K1/PRKACA/PRKACB/BAD/PDPK1/PRKAR2A/RAF1/MKNK1/AKT1/EIF4E2/IKBKB/SOCS2/SORBS1/PIK3CB/MAP2K2/CRKL	0.910587365428131
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/877	187/9376	1.20059268654077	IRF3/MAP1LC3A/CASP4/SUGT1/MFN1/TXN2/VDAC1/CYBA/TRAF3/TRIP6/IKBKB/MCU/TRPM7/GABARAPL1/TAB3/ATG5/RIPK1/TP53BP1/CCL5/MAPK11/RNF31	0.890027227516841
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/877	62/9376	1.37948284106374	EP300/MAML1/SNW1/NCOR2/RFNG/TLE2/CTBP1/ADAM17	0.962989144676933
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/877	18/9376	1.78183200304067	HEXA/MAN2B2/MAN2B1	1.06649714207656
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/877	10/9376	2.1381984036488	PAPSS1/BPNT1	1.15675774428177
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/877	142/9376	1.20461881895707	ACTG1/TXN2/CYBA/AKT1/IKBKB/MAP2K7/ITGAV/VEGFA/GSTM3/TP53/SDC2/ACVR2A/PIAS4/PIK3CB/HMOX1/MAPK11	0.789216817261557
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/877	103/9376	1.24555246814493	COL3A1/COL1A1/COL1A2/LAMA2/PRKACA/RAB5B/PRKACB/RAB7A/CASP3/HSPB1/PIK3CB/LAMC1	0.80492294311787
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/877	46/9376	1.39447721977096	FTL/BLVRB/HMOX1/COX15/UROS/BLVRA	0.861512420137135
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/877	37/9376	1.44472865111406	ASL/GLUD1/ADSL/GFPT1/GOT1	0.870657416576334
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/877	37/9376	1.44472865111406	MAP2K1/TP53/GADD45G/RXRA/MAP2K2	0.870657416576334
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/877	144/9376	1.18788800202711	TBX3/MAP2K1/RIF1/ZFHX3/RAF1/AKT1/WNT4/TCF3/PCGF6/ID4/ACVR2A/FZD3/PIK3CB/MAP2K2/MAPK11/MEIS1	0.729850511336902
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/877	105/9376	1.22182765922789	UBE2I/CSNK2A2/CXCL12/TRAF3/IKBKB/TAB3/TRADD/PIAS4/GADD45G/RIPK1/PLCG1/TRIM25	0.734257811841946
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/877	76/9376	1.26603852847626	ILK/PDPK1/ACOX1/HMGCS1/SORBS1/ACOX3/RXRA/DBI/ME1	0.748016846752426
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/877	20/9376	1.6036488027366	NANS/CYB5R4/UGP2	0.868072014023701
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/877	107/9376	1.1989897590554	EP300/CREB3L2/PRKACA/PPP4R3A/PRKACB/PPP3CC/AKT1/CREB3/PPP3CB/SIRT1/PFKM/SLC2A1	0.664978638122775
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/877	157/9376	1.15762333955508	MT-CO3/CASP7/MLXIP/NDUFV1/SDHB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/NDUFA9/NDUFA10/AKT1/IKBKB/CASP3/RXRA/PIK3CB/MAPK11	0.639778974724856
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/877	300/9376	1.10473584188521	MAP2K1/FGF10/PRKACA/PRKACB/RASA1/CACNB2/RRAS2/PPP3CC/RAF1/MKNK1/AKT1/IKBKB/MAP2K7/PPP3CB/MAPKAPK5/PPM1B/VEGFA/CASP3/TP53/HSPB1/TRADD/MAP3K4/GADD45G/RRAS/MAPK8IP3/NFATC3/MAP2K2/RPS6KA1/MAPK11/VEGFB/CRKL	0.592257040332146
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/877	178/9376	1.14117330531818	SFRP2/CSNK2A2/EP300/PRKACA/CBY1/PRKACB/PPP3CC/WNT4/CTNNBIP1/PPP3CB/SIRT1/LZTS2/TP53/SENP2/TLE2/FZD3/DAAM1/CTBP1/NFATC3	0.610825841340519
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/877	30/9376	1.42546560243253	PIGP/PIGU/PIGL/PIGM	0.749745234099537
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/877	168/9376	1.14546343052614	EP300/STAT5B/PIM1/SOCS6/RAF1/CSH1/AKT1/IL15/SOCS2/FHL1/PRLR/PIAS1/STAM2/STAM/PIAS4/PTPN11/PIK3CB/IL15RA	0.611121173996192
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/877	138/9376	1.16206434980913	MT-CO3/NDUFV1/MT-ATP8/SDHB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/NDUFA9/NDUFA10/PPA2/ATP6V0A1/ATP5F1A/ATP5MC3/COX15	0.616083497257929
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/877	69/9376	1.23953530646307	CREB3L2/PRKACA/PRKACB/PPP3CC/CREB3/PPP3CB/SIRT1/MAOB	0.641491260824595
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/877	89/9376	1.20123505822966	COL1A1/COL6A3/CD47/COL1A2/COL6A1/LAMA2/ITGAV/TNC/CD44/LAMC1	0.61272054743717
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/877	109/9376	1.17698994696264	CTSK/MAP2K1/IRF3/AKT1/TRAF3/IKBKB/MAP2K7/RIPK1/CCL5/PIK3CB/MAP2K2/MAPK11	0.597026745258384
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/877	109/9376	1.17698994696264	MLXIP/CREB3L2/PDPK1/AKT1/CREB3/OGA/IKBKB/GFPT1/SLC2A1/PTPN11/PIK3CB/RPS6KA1	0.597026745258384
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/877	31/9376	1.37948284106374	ALDH9A1/ACOX1/ACOX3/ECHS1	0.679805787581469
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/877	31/9376	1.37948284106374	MDH1/ACO1/AFMID/MCEE	0.679805787581469
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/877	110/9376	1.16629003835389	MAP2K1/PRKACA/PRKACB/CPEB2/RAF1/AKT1/ADCY9/MAD1L1/PIK3CB/FZR1/RPS6KA1/MAPK11	0.56353117736131
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/877	41/9376	1.30377951442	BABAM1/RBBP8/UIMC1/POLD2/RAD50	0.626173625372895
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/877	22/9376	1.45786254794237	ALDH9A1/CARNMT1/MAOB	0.69063613682837
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/877	101/9376	1.16436546733351	MAP2K1/EP300/CREB3L2/PRKACA/PRKACB/RAF1/CREB3/WNT4/ADCY9/FZD3/MAP2K2	0.533477155559827
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/877	91/9376	1.17483428771912	MAP2K1/PPP3CC/RAF1/AKT1/IKBKB/PPP3CB/NFATC3/PIK3CB/MAP2K2/LILRB1	0.538341513218544
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/877	71/9376	1.20461881895707	IKBKB/CASP3/ATP6V0A1/PLCG1/CCL5/PTPN11/MAPK11/ADAM17	0.555927399835056
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/877	13/9376	1.64476800280677	RAD50/XRCC4	0.747255571498736
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	19/877	183/9376	1.10999370681222	FBL/CSNK2A2/EMG1/WDR75/WDR36/NXF1/SBDS/GNL3L/NMD3/GNL3/NOP56/MDN1/XRN1/XPO1/EFL1/RBM28/UTP6/NOP58/HEATR1	0.48268774562682
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/877	52/9376	1.23357600210508	APOE/VDAC1/APOC1/OSBPL5/SORT1/MYLIP	0.542538147834503
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/877	23/9376	1.39447721977096	ASL/GLUD1/GOT1	0.608431793245158
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/877	23/9376	1.39447721977096	HMGCS1/PMVK/PCYOX1	0.608431793245158
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/877	154/9376	1.1107524174799	PDXK/MAT2B/DHRS3/RDH11/MAT2A/ADSL/GGCX/VKORC1L1/COQ4/UGP2/NADK/FLAD1/AFMID/BCAT2/COX15/UROS	0.445146062713663
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/877	216/9376	1.08889733519152	CASP7/ARHGEF1/IRF3/BAD/PDPK1/SOD2/PPP3CC/HSPA4/CYBA/AKT1/TRAF3/IKBKB/MAP2K7/PPP3CB/CASP3/TP53/PLCG1/RXRA/NFATC3/CCL5/PIK3CB/MAPK11	0.4245896483005
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/877	93/9376	1.14956903421979	MAP2K1/PRKACA/CGA/PRKACB/RAF1/MAP2K7/MAP3K4/ADCY9/MAP2K2/MAPK11	0.465629522965559
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/877	83/9376	1.15926419474935	CASP7/IRF3/SAMHD1/IKBKB/DNASE2/CASP3/RIPK1/CCL5/ZCCHC3	0.468145386673467
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/877	155/9376	1.103586272851	ACTG1/STX18/SEC61A1/M6PR/RAB5B/TUBA1C/C1R/C3/CYBA/ITGAV/RAB7A/ATP6V0A1/HLA-DPB1/PIK3C3/MRC2/SEC22B	0.417715475508205
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/877	125/9376	1.11186316989738	MAP2K1/PDPK1/RAF1/SPTLC2/AKT1/PPP2CB/TP53/TRADD/CERS4/PIK3CB/MAP2K2/MAPK11/FCER1G	0.404435536005216
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/877	24/9376	1.3363740022805	B3GAT3/B4GALT7/HS2ST1	0.530001763502521
Organismal Systems	Immune system	hsa04611	Platelet activation	13/877	126/9376	1.10303885902518	COL3A1/COL1A1/ACTG1/COL1A2/ARHGEF1/PRKACA/PRKACB/AKT1/ARHGAP35/ADCY9/PIK3CB/MAPK11/FCER1G	0.374039069083242
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/877	65/9376	1.15133760196474	MAP2K1/CGA/RAF1/AKT1/TRPC4/PIK3CB/MAP2K2	0.393284547826887
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/877	15/9376	1.42546560243253	HEXA/ST6GALNAC6	0.529725014650776
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/877	180/9376	1.0690992018244	IRF3/SRSF6/NXF1/BAD/EIF2B1/C3/AKT1/SRPK1/TRAF3/IKBKB/CASP3/TP53/HLA-DPB1/TRADD/TNFRSF14/CCL5/PTPN11/PIK3CB	0.300684694624332
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/877	128/9376	1.08580387685291	PAPSS1/NTPCR/ADK/ADSL/GMPS/NT5C/PDE4B/DCK/ADCY9/PGM1/GART/PRPS1/ADA	0.313970977753127
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/877	243/9376	1.05590044624632	ZMAT2/SLU7/CASC3/LSM4/DDX39B/ACIN1/SRSF6/NCBP1/SNRPB2/SNRNP200/SNRPA/CDC5L/DDX5/PHF5A/THOC6/SNRNP27/USP39/SNW1/DHX38/SNIP1/DHX8/EFTUD2/HNRNPC/PPIH	0.283604555812889
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/877	139/9376	1.07679056298861	MAP2K1/CREB3L2/PRKACA/PRKACB/RAF1/AKT1/CREB3/FKBP4/NCOA2/ADCY9/NCOA3/FKBP5/PIK3CB/MAP2K2	0.292988989694383
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/877	56/9376	1.14546343052614	SAR1A/CASP7/C3/CASP3/RAB1A/SEC22B	0.350704552174759
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/877	181/9376	1.06319257639996	EP300/RAB5B/BAD/PPP3CC/RAF1/C3/AKT1/CASP10/PPP3CB/RAB7A/CASP3/ATP6V0A1/HLA-DPB1/TRADD/PIK3C3/MRC2/MAPK11/FCER1G	0.275759830266681
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/877	36/9376	1.18788800202711	POLE3/RFC1/POLD2/RNASEH2B	0.362809274789769
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/877	26/9376	1.23357600210508	ACOX1/ACOX3/PLAAT3	0.383098639415566
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/877	57/9376	1.12536758086779	HADHB/ACOX1/ACADVL/ACOX3/ECHS1/ACAA2	0.304957653925754
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/877	78/9376	1.09651200187118	ACTG1/WASL/ILK/ARPC4/DNM2/WASF1/PIK3CB/CRKL	0.274938383320668
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/877	99/9376	1.07989818366101	MAP2K1/PDPK1/RAF1/AKT1/PIP5K1C/WASF1/PLCG1/PIK3CB/PIP5K1A/MAP2K2	0.256715591296935
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/877	16/9376	1.3363740022805	GOT1/MAOB	0.432559654651233
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/877	47/9376	1.13733957640894	ALDH9A1/GLO1/MDH1/ADH5/ME1	0.303199587617649
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/877	37/9376	1.15578292089124	GOT1/FAHD1/ADH5/MAOB	0.304980475420509
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/877	323/9376	1.02607044137946	TIMP3/ZEB1/UBE2I/MAP2K1/EP300/EZR/DNMT1/PIM1/E2F3/CDKN1B/RAF1/CDK6/RECK/VIM/IKBKB/SIRT1/VEGFA/MDM4/CASP3/TP53/TNC/FZD3/PLCG1/CD44/MMP16/PIK3CB/HMOX1/MAP2K2/HDAC4/MDM2/CRKL	0.153163367102373
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/877	122/9376	1.05157298540105	CREB3L2/CAMKK2/PDPK1/AKT1S1/AKT1/CREB3/SIRT1/PFKM/PPP2CB/EEF2/PFKFB3/PIK3CB	0.184178512080243
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/877	38/9376	1.12536758086779	SIRT7/NT5C/SIRT1/NADK	0.248743436174886
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/877	17/9376	1.25776376685224	CA5B/GLUD1	0.341690675237736
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/877	155/9376	1.03461213079781	MAP2K1/CREB3L2/PRKACA/E2F3/PRKACB/CDK4/CDKN1B/CDK6/CREB3/WNT4/ADCY9/FZD3/ARNT/PBX1/MAP2K2	0.139574697270514
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/877	70/9376	1.0690992018244	CAMKK2/AKT1/IKBKB/TRADD/SLC2A1/RXRA/PTPN11	0.18639834283908
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/877	49/9376	1.09091755288204	CREB3L2/PRKACA/PRKACB/CREB3/MAOB	0.204963396718305
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/877	28/9376	1.14546343052614	HADHB/ECHS1/ACAA2	0.24761389377919
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/877	93/9376	1.03461213079781	ACTG1/CSNK2A2/EP300/WASL/CCM2/SORBS1/BAIAP2/KRIT1/WASF1	0.107752450473954
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/877	93/9376	1.03461213079781	MAML1/STAT5B/PPP3CC/IKBKB/PPP3CB/HLA-DPB1/PLCG1/NFATC3/MAPK11	0.107752450473954
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/877	61/9376	1.05157298540105	FTL/SLC40A1/TRPM7/CYBRD1/HMOX1/SLC8A1	0.129806751113649
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	34/877	362/9376	1.00412632215552	COL1A1/COL6A3/MAP2K1/COL1A2/COL6A1/CREB3L2/LAMA2/FGF10/RBL2/BAD/CDK4/PDPK1/CDKN1B/RAF1/CDK6/CSH1/AKT1/CREB3/SGK3/EIF4E2/IKBKB/ITGAV/PPP2CB/VEGFA/TP53/PRLR/TNC/MLST8/RXRA/PIK3CB/MAP2K2/LAMC1/MDM2/VEGFB	0.0257193601780418
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/877	94/9376	1.02360561876804	MAPK6/TRAF3/IKBKB/USP25/CASP3/TAB3/TRADD/TRAF3IP2/MAPK11	0.0738856424565726
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/877	148/9376	1.01131005577984	MAP2K1/FGF10/E2F3/CDK4/RAF1/CDK6/AKT1/WNT4/TP53/GADD45G/FZD3/NCOA3/PIK3CB/MAP2K2	0.0445495510583155
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/877	105/9376	1.01818971602324	ACTG1/LAMA2/PRKACA/PRKACB/CACNB2/SGCB/ITGAV/TPM2/ADCY9/SLC8A1	0.0602086373346678
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/877	116/9376	1.01380096724728	ACTG1/CXCL12/EZR/CLDN4/CYBA/ARHGAP35/ARHGAP5/PLCG1/PTPN11/PIK3CB/MAPK11	0.0480434898468341
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/877	138/9376	1.00712243650125	MAP2K1/PRKACA/PRKACB/PPP3CC/CPEB2/SMC3/SMC1A/PPP3CB/PPP2CB/ADCY9/MAD1L1/RPS6KA1/MAPK11	0.0270757609175248
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/877	149/9376	1.00452273996924	MAP2K1/RRAS2/RAF1/DNM2/AKT1/PIP5K1C/ADCY9/RRAS/PLCG1/PTPN11/PIK3CB/PIP5K1A/MAP2K2/FCER1G	0.0178758216616712
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/877	19/9376	1.12536758086779	BCKDHB/DLST	0.175709503537653
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/877	140/9376	0.992734973122658	MAP2K1/MAP1LC3A/PRKACA/PRKACB/RRAS2/RAF1/AKT1/PIK3C3/ADCY9/RRAS/MAP2K2/HDAC4/SLC8A1	-0.0278202354558144
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/877	238/9376	0.988242959669615	MAP2K1/FGF10/PRKACA/PAK3/RAB5B/PRKACB/BAD/RASA1/RRAS2/RAF1/TIAM1/AKT1/IKBKB/RASA3/VEGFA/PLAAT3/RRAS/PLCG1/PTPN11/PIK3CB/MAP2K2/VEGFB	-0.0590150025056893
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/877	75/9376	0.997825921702775	CREB3L2/PRKACA/CGA/PRKACB/CREB3/ADCY9/GPX8	-0.0060721502671202
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/877	109/9376	0.980824955802203	RORA/STAT5B/PPP3CC/IKBKB/PPP3CB/HLA-DPB1/PLCG1/RXRA/NFATC3/MAPK11	-0.0646817201996939
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/877	65/9376	0.986860801684063	CREB3L2/PRKACA/PRKACB/CREB3/ADCY9/PBX1	-0.0341451404106106
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/877	32/9376	1.00228050171038	CASP7/CASP3/BOK	0.00415088304440395
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/877	166/9376	0.966053495624459	MAP2K1/CREB3L2/BAD/PPP3CC/VDAC1/RAF1/AKT1/CREB3/SLC25A4/PPP3CB/ADCY9/PPIF/NFATC3/MAP2K2/SLC8A1	-0.141749262774878
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/877	89/9376	0.960988046583731	MAP2K1/PRKACA/CSNK1D/PRKACB/TUBA1C/RAF1/ADCY9/MAP2K2	-0.118783603931125
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/877	78/9376	0.959448001637283	CASP7/IRF3/C1R/C3/C1S/CASP3/MAPK11	-0.115522428859669
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/877	233/9376	0.963565804219418	FBLN1/COL3A1/VCAN/COL1A1/COL6A3/ACTG1/ZYX/COL1A2/COL6A1/LAMA2/PDLIM4/PLEC/SGCB/VIM/ITGAV/TPM2/FHL1/SDC2/DAAM1/ENO1/DCN	-0.180902391661756
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/877	67/9376	0.957402270290509	ALDH9A1/PFKM/ADPGK/PGM1/ADH5/ENO1	-0.112401953718317
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/877	112/9376	0.954552858771787	LAMA2/BAD/PDPK1/AKT1/IKBKB/CASP3/HLA-DPB1/PPIF/MAPK11/LAMC1	-0.155423909280579
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/877	212/9376	0.958154945031303	ACTG1/MAP2K1/FGF10/CNR1/RAF1/TIAM1/AKT1/ENAH/VEGFA/KRIT1/ADCY9/RRAS/PLCG1/PIK3CB/MAP2K2/SIPA1L2/MAPK11/VEGFB/CRKL	-0.197957086432717
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/877	34/9376	0.943322825139178	RORA/RORB/CSNK1D	-0.106347979092458
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/877	193/9376	0.941693597461908	MAP2K1/CXCL12/PRKACA/STAT5B/PRKACB/BAD/RAF1/TIAM1/AKT1/IKBKB/CXCL14/ADCY9/PLCG1/CCL5/PIK3CB/GRK4/CRKL	-0.262908198439027
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/877	104/9376	0.925182001578809	SAMD8/LPIN1/PLD3/LPIN2/GNPAT/PEMT/PLAAT3/GPD2/PNPLA6	-0.246454960572279
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/877	23/9376	0.929651479847305	MDH1/GLUD1	-0.108503797237009
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/877	35/9376	0.916370744420915	ENOSF1/PFKM/PFKFB3	-0.159219804875312
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/877	217/9376	0.936077642150397	MAP2K1/CREB3L2/FGF10/PRKACA/KPNA2/STAT5B/PRKACB/BAD/RAF1/AKT1/CREB3/VEGFA/GSTM3/ADCY9/ARNT/RXRA/PIK3CB/MAP2K2/RPS6KA1	-0.306027281042456
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/877	150/9376	0.926552641581148	MAP2K1/FGF10/E2F3/CDKN1B/RAF1/AKT1/WNT4/TP53/GADD45G/FZD3/RXRA/PIK3CB/MAP2K2	-0.291283983603454
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/877	36/9376	0.890916001520334	UGP2/GAA/PGM1	-0.210639774507074
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/877	36/9376	0.890916001520334	GALNT13/GALNT1/GALNT11	-0.210639774507074
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/877	50/9376	0.855279361459521	CXCL12/IL15/HLA-DPB1/IL15RA	-0.329586403184755
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/877	201/9376	0.904213255274369	ZEB1/ATF1/CDKN1B/DDX5/TCF3/CCNT1/CCNT2/SUPT3H/TP53/GADD45G/PBX1/HOXA9/RXRA/NCOR1/TFE3/MEIS1/MDM2	-0.440962772725309
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/877	168/9376	0.890916001520334	FTL/STAT5B/CHMP2B/CAPN1/CAPN2/VDAC1/GLUD1/CHMP2A/SLC25A4/CHMP4A/TRPM7/TRADD/RIPK1/RNF31	-0.45828385164552
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/877	134/9376	0.8776187477663	MYL6B/MAP2K1/ARHGEF1/PRKACA/PPP1R12C/PRKACB/RAF1/PPP1R12B/ADCY9/MAP2K2/ARHGEF11	-0.458337962755
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/877	39/9376	0.822384001403386	MAT2B/MAT2A/GART	-0.35703617917366
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/877	226/9376	0.898800213923169	MAP2K1/EP300/CREB3L2/PRKACA/CGA/PRKACB/BAD/RRAS2/ACOX1/RAF1/TIAM1/AKT1/CREB3/ACOX3/PDE4B/ADCY9/RRAS/PIK3CB/MAP2K2	-0.494680495654476
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/877	238/9376	0.898402690608741	CFD/RPL13A/RPL3/RPS2/RPLP0/RPL18A/IRF3/RPL26L1/RPL6/C1R/C3/TRAF3/IKBKB/RPL12/C1S/RPL10A/PLCG1/PIK3CB/MAPK11/ADAM17	-0.509972348466035
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/877	88/9376	0.850419819633046	CFD/PLAUR/C1R/C3/F3/C1S/F10	-0.452851494711248
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/877	52/9376	0.822384001403386	PRKACA/CGA/PRKACB/ADCY9	-0.412557172123495
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/877	170/9376	0.880434636796566	ACTG1/MYL6B/EZR/PRKACA/PRKACB/CDK4/TUBA1C/CLDN4/HSPA4/ARPC4/TIAM1/MAP2K7/PPP2CB/SYMPK	-0.50535420423755
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/877	27/9376	0.791925334684742	HMGCS1/ECHS1	-0.347792351698462
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/877	27/9376	0.791925334684742	ACOX1/ACOX3	-0.347792351698462
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/877	194/9376	0.881731300473733	ACTG1/MYL6B/DCTN3/MYO5A/DCTN1/KIF16B/TUBA1C/MYO9A/DYNLT3/TPM2/DCTN2/HOOK3/KIF2A/MYO19/ACTR1B/DCTN5	-0.534691847452272
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/877	149/9376	0.861019491402202	PRKACA/NDUFV1/PRKACB/NDUFA5/NDUFS1/NDUFB1/NDUFV3/NDUFA9/CNR1/NDUFA10/ADCY9/MAPK11	-0.549310993566183
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/877	28/9376	0.76364228701743	B4GALT1/B4GALT2	-0.402337916991719
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/877	28/9376	0.76364228701743	CBR1/QDPR	-0.402337916991719
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/877	55/9376	0.777526692235928	HEXA/SAMD8/SPTLC2/CERS4	-0.531532131456005
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/877	15/9376	0.712732801216267	NTPCR	-0.357661395455652
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/877	30/9376	0.712732801216267	IKBKB/GART	-0.506215336727202
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/877	142/9376	0.828175438032987	CTSK/MAP2K1/PPP3CC/CYBA/AKT1/IKBKB/MAP2K7/PPP3CB/PIK3CB/MAPK11/LILRB1	-0.662729042295062
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/877	16/9376	0.668187001140251	HEXA	-0.426694438994945
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/877	70/9376	0.76364228701743	ACTG1/LAMA2/SGCB/CASP3/HLA-DPB1	-0.637586033615053
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/877	95/9376	0.787757306607454	CTSK/CXCL12/IL15/VEGFA/ATP6V0A1/HLA-DPB1/CCL5	-0.667880378849889
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/877	133/9376	0.803833986334136	MAP2K1/PPP3CC/RAF1/PPP3CB/CASP3/PLCG1/PTPN11/PIK3CB/MAP2K2/FCER1G	-0.731888007512699
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/877	133/9376	0.803833986334136	CREB3L2/PRKACA/PRKACB/PPP3CC/AKT1/CREB3/PPP3CB/PPP2CB/MAOB/MAPK11	-0.731888007512699
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/877	17/9376	0.628881883426118	ACOT8	-0.491952772857246
Human Diseases	Immune disease	hsa05310	Asthma	2/877	32/9376	0.668187001140251	HLA-DPB1/FCER1G	-0.603953482960765
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/877	59/9376	0.724813018186035	GSTK1/IDH1/GSTM3/GPX8	-0.68111016741524
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/877	110/9376	0.777526692235928	EP300/ZFYVE16/PPP2CB/ID4/ACVR2A/NBL1/NCOR1/DCN	-0.753927573153499
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/877	98/9376	0.76364228701743	CREB3L2/PRKACA/PRKACB/ATF1/CREB3/CAMK1/ADCY9	-0.755539462881977
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/877	195/9376	0.822384001403386	ACTG1/MAP2K1/CASP4/VDAC1/RAF1/C3/CYBA/AKT1/SLC25A4/PLCG1/PPIF/PIK3CB/MAP2K2/MAPK11/HDAC4	-0.805111285124916
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/877	60/9376	0.712732801216267	MAP2K1/RAF1/PPP2CB/MAP2K2	-0.717048356987236
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/877	86/9376	0.745883164063536	CREB3L2/PRKACA/PRKACB/CREB3/SLC2A1/ADCY9	-0.760459917489064
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/877	86/9376	0.745883164063536	ACTG1/LAMA2/CACNB2/SGCB/ITGAV/SLC8A1	-0.760459917489064
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/877	47/9376	0.682403745845362	IKBKB/SOCS2/PIK3CB	-0.701145698905253
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/877	99/9376	0.755928728562708	ACTG1/LAMA2/CACNB2/SGCB/ITGAV/TPM2/SLC8A1	-0.784209326102544
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/877	76/9376	0.703354738042369	ACTG1/EZR/PRKACA/PRKACB/ADCY9	-0.834073375478737
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/877	63/9376	0.678793144015493	PTGDS/LTA4H/CBR1/PLAAT3	-0.821697186591828
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/877	63/9376	0.678793144015493	WNT4/TP53/GADD45G/FZD3	-0.821697186591828
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/877	115/9376	0.743721183877844	MAP2K1/CREB3L2/PRKACA/PRKACB/AKT1/CREB3/ADCY9/PIK3CB	-0.88824793690081
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/877	103/9376	0.726572273084545	COL3A1/COL1A1/COL6A3/COL1A2/SLC1A5/COL6A1/SLC8A1	-0.896298263020976
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/877	103/9376	0.726572273084545	C3/AKT1/IKBKB/PPP2CB/CCL5/PIK3CB/MAPK11	-0.896298263020976
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/877	20/9376	0.534549600912201	CYP51A1	-0.66933697794574
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/877	154/9376	0.76364228701743	CREB3L2/PRKACA/PRKACB/CACNB2/AKT1/CREB3/PPP2CB/TPM2/ADCY9/MAPK11/SLC8A1	-0.949990146673724
NA	NA	hsa04517	IgSF CAM signaling	23/877	299/9376	0.822384001403386	ACTG1/MYL6B/MAP2K1/WASL/EZR/PAK3/ICAM3/RASA1/TUBA1C/PDPK1/ARPC4/AKT1/NLGN2/SORBS1/BAIAP2/PLCG1/PTPN11/PIK3CB/LRFN4/MAP2K2/MAPK11/KIRREL1/NLGN1	-1.00264693044599
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/877	51/9376	0.628881883426118	PLD3/PLA2G7/PLAAT3	-0.853639187051969
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/877	65/9376	0.657907201122709	ALDH9A1/ABHD16A/LPIN1/LPIN2	-0.889004516885605
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/877	21/9376	0.50909485801162	BCAT2	-0.723413906029866
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/877	79/9376	0.676645064445824	GSTK1/AKR7A2/CBR1/GSTM3/ADH5	-0.927092664200631
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/877	79/9376	0.676645064445824	DNM2/AP2B1/AP2A1/AP2A2/ATP6V0A1	-0.927092664200631
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/877	38/9376	0.562683790433895	PDPK1/PIK3CB	-0.867684738825465
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/877	38/9376	0.562683790433895	UNG/ADA	-0.867684738825465
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/877	68/9376	0.628881883426118	ALDH1A1/DHRS3/RDH11/ADH5	-0.986597350376052
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/877	54/9376	0.593944001013556	REV3L/ATR/FANCM	-0.961235456378807
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/877	23/9376	0.464825739923653	PREP	-0.825439387719175
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/877	69/9376	0.619767653231537	PRKACA/PRKACB/PPP3CC/PPP3CB	-1.01828716249142
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/877	99/9376	0.647938910196607	PRKACA/PRKACB/ADCY9/PLCG1/PIK3CB/MAPK11	-1.13118429856904
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/877	99/9376	0.647938910196607	CFD/C1R/C3/C1S/HLA-DPB1/PTAFR	-1.13118429856904
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/877	73/9376	0.58580778182159	GSTK1/GSTM3/ADH5/MAOB	-1.14117795895882
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/877	90/9376	0.593944001013556	PRKACA/PRKACB/SLC2A1/ADCY9/RXRA	-1.24335277037854
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/877	28/9376	0.381821143508715	ATP6V0A1	-1.05228972776263
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/877	91/9376	0.587417143859561	PRKACA/PRKACB/PDE4B/ADCY9/GRK4	-1.27040571961206
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/877	160/9376	0.668187001140251	VCAN/CD276/ICAM3/CLDN4/NLGN2/ITGAV/HLA-DPB1/SDC2/GLG1/NLGN1	-1.35982704423547
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/877	78/9376	0.54825600093559	C3/CYBA/HLA-DPB1/MAPK11	-1.28690486540068
NA	NA	hsa03272	Virion - Hepatitis viruses	2/877	48/9376	0.445458000760167	CLDN4/CHMP4A	-1.23726382157948
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/877	48/9376	0.445458000760167	AKT1/PIK3CB	-1.23726382157948
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/877	30/9376	0.356366400608134	PLAAT3	-1.13419562214057
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/877	254/9376	0.715538835866725	FGF10/PRKACA/PRKACB/PPP3CC/VDAC1/CAMK1/SLC25A4/PPP3CB/MCU/VEGFA/ADCY9/PLCG1/PPIF/NFATC3/PTAFR/VEGFB/SLC8A1	-1.47637379360054
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/877	31/9376	0.344870710265936	ALDH9A1	-1.17359899996254
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/877	50/9376	0.427639680729761	SDC2/GYPC	-1.30349189207863
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/877	82/9376	0.521511805768001	GMPS/UCKL1/GSTM3/CDADC1	-1.39790719197062
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/877	115/9376	0.557790887908383	MAP2K1/PRKACA/PRKACB/RAF1/CASP3/MAOB	-1.53267186667076
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/877	70/9376	0.458185372210458	GSTK1/CBR1/GSTM3	-1.46157041006919
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/877	116/9376	0.552982345771242	PRKACA/PRKACB/PPP3CC/PPP3CB/ADCY9/HOMER3	-1.5561436925033
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/877	54/9376	0.395962667342371	CGA/HLA-DPB1	-1.42990647244785
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/877	87/9376	0.491539862907771	MT-CO3/CACNB2/TPM2/SLC8A1	-1.53050085078616
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/877	36/9376	0.296972000506778	UGP2	-1.35753787310076
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/877	89/9376	0.480494023291866	PRKACA/PRKACB/GABARAPL1/ADCY9	-1.58179190666772
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/877	37/9376	0.288945730222811	APOL1	-1.39205034804696
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/877	39/9376	0.274128000467795	HLA-DPB1	-1.45911723791678
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/877	41/9376	0.260755902884	MAOB	-1.52378660954288
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/877	97/9376	0.440865650236867	PRKACA/PRKACB/ADCY9/NOS1AP	-1.77808686383053
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/877	82/9376	0.391133854326	HSPA4/PSME2/HLA-DPB1	-1.77880744863776
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/877	44/9376	0.242977091323728	HLA-DPB1	-1.61677474107131
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/877	100/9376	0.427639680729761	CXCL12/CXCL14/TNFRSF14/CCL5	-1.84837747556879
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/877	45/9376	0.237577600405423	ABCB7	-1.64679420328659
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/877	45/9376	0.237577600405423	HLA-DPB1	-1.64679420328659
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/877	66/9376	0.323969455098303	RORA/HLA-DPB1	-1.77037377045227
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/877	93/9376	0.344870710265936	PRKACA/PRKACB/ADCY9	-2.03950998447567
NA	NA	hsa04081	Hormone signaling	11/877	219/9376	0.536990466669791	PRKACA/CGA/STAT5B/SLC40A1/PRKACB/CSH1/THRA/ITGAV/PRLR/ADCY9/PIK3CB	-2.2270855689375
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/877	191/9376	0.503764021802074	MAP2K1/CREB3L2/PRKACA/CAMKK2/PRKACB/RAF1/CREB3/MAOB/HDAC4	-2.22570126146669
NA	NA	hsa04382	Cornified envelope formation	10/877	217/9376	0.492672443237051	S100A4/CAPN1/PLEC/CLDN4/SPTLC2/ABHD5/PPP2CB/S100A6/S100A13/BLMH	-2.42882268453498
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/877	86/9376	0.248627721354512	PRKACA/PRKACB	-2.24852674131823
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/877	143/9376	0.373810909728812	C1R/C3/C1S/SSB/HLA-DPB1	-2.42383815743295
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/877	66/9376	0.161984727549152	STS	-2.19457577586399
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/877	157/9376	0.340477452810319	ACTG1/CSNK1D/WNT4/PPP2CB/FZD3	-2.67694276900841
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/877	100/9376	0.21381984036488	HLA-DPB1/CD44	-2.53888616992424
NA	NA	hsa04519	Cadherin signaling	19/877	404/9376	0.502794179075832	ACTG1/MAP2K1/EP300/RRAS2/RAF1/ARPC4/ARHGAP35/VIM/WNT4/IKBKB/ENAH/LHFPL2/WASF1/FZD3/RRAS/DAAM1/CYFIP1/MAP2K2/MAPK11	-3.28158588316587
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/877	102/9376	0.104813647237686	ADCY9	-2.91999100126917
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/877	298/9376	0.394633933559343	CXCL12/CSH1/IL15/CXCL14/PRLR/ACVR2A/TNFRSF14/TNFRSF12A/CCL5/IL15RA/TNFRSF18	-3.41139992986662
NA	NA	hsa04082	Neuroactive ligand signaling	4/877	199/9376	0.214894311924503	PRKACA/PRKACB/OGFRL1/ADCY9	-3.59588518489147
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/877	370/9376	0.26005115720053	CGA/CNR1/NMB/C3/CSH1/OGFRL1/THRA/PRLR/PTAFR	-4.66485454252716
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/877	449/9376	0.0714320179392696	PRKACA/PRKACB/SLC8A1	-6.47717495681502