category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	106/836	238/9376	4.99505448112259	RPL27A/RPS16/RPL13A/RPS2/CFD/RPL18A/RPS9/RPL12/RPL6/RPL3/RPS4X/RPL10/FOS/JUN/RPLP0/RPL5/RPL7/RPL9/RPS27/RPS20/RPL23A/RPL15/RPS23/RPL29/RPL14/RPL37A/RPS29/RPL10A/RPL37/RPS6/RPL7A/RPS5/RPL17/RPS27A/RPS11/RPL34/RPL30/RPS18/RPSA/RPL31/RPL21/RPL18/RPL22/RPS25/RPS3A/RPS3/RPL11/RPS14/RPL23/RPS13/NFKBIA/RPS15A/RPS8/RPL4/RPL32/C1S/RPL8/RPL24/RPL13/RPS19/RPL36A/RPL26/RPS21/RPL39/RPS17/RPLP2/RPS24/NRP1/RPS12/RPL27/NFKB1/RPS26/RPL28/FAU/RPL41/CXCL8/C2/RPL36/RPS28/UBA52/RPL35A/RPS10/C1R/RPL38/RPS15/RPL19/EGFR/PRKCA/PIK3R1/C1QC/SYK/STAT3/TBK1/ACE2/MYD88/C3AR1/F13A1/IL6/VWF/FCGR2A/TNFRSF1A/STAT2/ACE/CYBB/TNF/NFKBIB	19.5319430564438
Genetic Information Processing	Translation	hsa03010	Ribosome	80/836	222/9376	4.04155351523773	RPL27A/RACK1/RPS16/RPL13A/RPS2/RPL18A/RPS9/RPL12/RPL6/RPL3/RPS4X/RPL10/RPLP0/RPL5/RPL7/RPL9/RPS27/RPS20/RPL23A/RPL15/RPS23/RPL29/RPL14/RPL37A/RPS29/RPL10A/RPL37/RPS6/RPL7A/RPS5/RPL17/RPS27A/RPS11/RPL34/RPL30/RPS18/RPSA/RPL31/RPL21/RPL18/RPL22/RPS25/RPS3A/RPS3/RPL11/RPS14/RPL23/RPS13/RPS15A/RPS8/RPL4/RPL32/RPL8/RPL24/RPL13/RPS19/RPL36A/RPL26/RPS21/RPL39/RPS17/RPLP2/RPS24/RPS12/RPL27/RPS26/RPL28/FAU/RPL41/RPL36/RPS28/UBA52/MRPS24/RPL35A/RPS10/RPL38/RPS15/RPL19/MRPL18/MRPL51	14.3491553312356
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	51/836	203/9376	2.81763971056167	COL6A1/COL1A2/COL6A2/JUN/COL6A3/ACTG1/TNXB/LAMB1/PAK3/LAMA2/CAV1/COL1A1/FN1/ITGB1/FYN/ITGAV/EMP1/ITGA5/COL4A1/THBS2/FLNA/VCL/LAMC1/PDGFRB/CCND2/COL4A2/RAC1/EGFR/PRKCA/PIK3R1/ACTN4/PTEN/ACTB/VASP/ZYX/IGF1/PXN/CCND1/AKT3/PPP1R12A/CAPN2/DOCK1/VAV1/PARVG/BCL2/VWF/ERBB2/IGF1R/THBS3/GSK3B/VEGFA	8.19143455971527
NA	NA	hsa04518	Integrin signaling	43/836	154/9376	3.13154787795936	COL6A1/COL1A2/COL6A2/COL6A3/ACTG1/TNXB/LAMB1/LAMA2/COL1A1/FN1/ITGB1/ITGAV/ITGA5/COL4A1/THBS2/FBN1/FLNA/VCL/LAMC1/PDGFRB/CCND2/COL4A2/RAC1/EGFR/ICAM1/PIK3R1/ACTN4/ACTB/IGF1/LIMS1/PXN/TGFB1/CCND1/AKT3/ITGB2/PARVG/VWF/ERBB2/IGF1R/THBS3/GSK3B/ITGAM/VEGFA	8.3445464227538
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	34/836	103/9376	3.70214149672504	COL1A2/COL3A1/LAMB1/LAMA2/COL1A1/RAB7A/FN1/NFKB1/CXCL8/COL4A1/RAB7B/VCL/LAMC1/SERPINB6/COL4A2/IL1R1/CXCL2/PRKCA/PIK3R1/ACTN4/ADCY1/PLCB1/TGFB1/CD14/GNA11/PRDX1/ITGB2/HSPB1/CXCL1/IL6/GNA14/PLCB4/ITGAM/TNF	8.62733001288352
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	30/836	101/9376	3.3312804964707	COL1A2/JUN/EGR1/COL3A1/COL1A1/FOXO1/FN1/NFKB1/CXCL8/COL4A1/COL4A2/RAC1/ICAM1/PRKCA/PIK3R1/CDK4/PLCB1/STAT3/TGFB1/CCND1/AKT3/PIM1/BCL2/TGFBR2/IL6/CYBB/PLCB4/TNF/VEGFA/PRKCE	7.3698406842282
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	46/836	204/9376	2.52894267754949	COL1A2/DDX5/CD44/RPS6/ACTG1/CAV1/COL1A1/FN1/ITGB1/MYC/TWIST2/ITGAV/ITGA5/EIF4B/TWIST1/FLNA/RAC1/EGFR/PRKCA/PIK3R1/HSPB2/HPSE2/ACTB/HSPG2/MAP2K2/IGF1/STAT3/PTPN11/PXN/TGFB1/CCND1/MSN/SLC9A1/PDCD4/AKT3/PPP1R12A/VAV1/PTPN6/MDM2/CDKN1A/ERBB2/WNT2/IGF1R/FZD10/TNF/VEGFA	6.90771014160708
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	66/836	362/9376	2.04478045943588	COL6A1/COL1A2/COL6A2/COL6A3/RPS6/MCL1/HSP90AA1/TNXB/LAMB1/LAMA2/GNG4/COL1A1/HSP90AB1/FN1/ITGB1/MYC/NFKB1/ITGAV/ITGA5/COL4A1/EIF4B/THBS2/YWHAB/LAMC1/PDGFRB/ATF4/CCND2/NR4A1/CSH1/COL4A2/FGF10/RAC1/EFNA5/EGFR/KITLG/PRKCA/PIK3R1/MAGI1/CDK4/FLT3LG/PTEN/FGF7/MAP2K2/IGF1/GNG2/CREB5/CSF1R/SYK/CCND1/AKT3/MDM2/BCL2/IL2RG/CDKN1A/IL6/VWF/MAGI2/ERBB2/PIK3CG/YWHAQ/IGF1R/PIK3R5/BRCA1/THBS3/GSK3B/VEGFA	6.34279085499507
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	28/836	106/9376	2.96253498239596	HSP90AA1/NFKBIA/HSP90AB1/FOXO1/ZEB1/NFKB1/PDGFRB/ATF4/TCF7/EGFR/PIK3R1/PTEN/MAP2K2/FOLR2/IGF1/PLAT/AR/CREB5/CCND1/AKT3/TCF7L2/MDM2/BCL2/CDKN1A/ERBB2/IGF1R/GSK3B/TCF7L1	6.35755775161773
NA	NA	hsa04517	IgSF CAM signaling	55/836	299/9376	2.06301707445872	ACTG1/PAK3/ARPC2/MYL6/FOXO1/TUBB4B/NRP1/ITGB1/PMP22/FYN/ITGA5/TUBB3/VCL/TUBA1C/LYN/RAC1/INPP5D/NLGN1/EPB41L3/SRGAP3/ICAM1/PRKCA/PIK3R1/MAGI1/ACTN4/MYH9/ACTB/TRIO/APP/MAP2K2/TUBB2A/PTPN11/PXN/KIRREL1/MSN/MTSS1/TUBB/AKT3/ITGB2/PTPRF/VAV1/RAPGEF6/PTPN6/SH2D1B/MBP/BAIAP2/GIT1/SPTAN1/MAGI2/NLGN4X/JAM2/CASK/ABL1/GSK3B/ITGAM	5.84473073774347
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	55/836	300/9376	2.05614035087719	FOS/JUN/GADD45A/DUSP1/JUND/CACNB2/MYC/NFKB1/MAP3K8/FLNA/HSPA8/PDGFRB/ATF4/NR4A1/IL1R1/DUSP16/FGF10/RAC1/EFNA5/EGFR/HSPA1A/KITLG/CACNA1C/PRKCA/FLT3LG/HSPA1B/GADD45B/MAPKAPK2/FGF7/MAP2K2/IGF1/DUSP6/DUSP2/CSF1R/TGFB1/CD14/TAOK3/STK3/AKT3/DUSP5/RPS6KA5/HSPB1/MYD88/PTPN5/TGFBR2/TNFRSF1A/MAP4K3/ERBB2/ARRB1/IGF1R/RASGRP1/TNF/STK4/VEGFA/RASGRP3	5.81694370625596
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	41/836	196/9376	2.34605995508251	FOS/JUN/RPS27A/MAP1LC3B/CALM1/NFKBIA/UBC/GNG4/MYC/NFKB1/CLEC2B/CXCL8/UBA52/LYN/CXCL2/TCF7/RAC1/ICAM1/PIK3R1/ZFP36/CDK4/MAPKAPK2/MAP2K2/GNG2/SYK/STAT3/TBK1/CCND1/AKT3/TCF7L2/CXCL1/CDKN1A/IL6/TNFRSF1A/STAT2/PIK3CG/NFATC4/PIK3R5/GSK3B/TCF7L1/VEGFA	5.95841764344581
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/836	56/9376	3.80519480519481	EEF1A1/EEF1G/NFKBIA/NFKB1/CXCL8/CLK1/HSPA8/HSPD1/CXCL2/HSPA1A/VCP/HSPA1B/CD14/ITGB2/MYD88/CXCL1/IL6/ITGAM/TNF	6.5873224828444
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	46/836	233/9376	2.21418157176007	COL6A1/COL1A2/COL6A2/COL6A3/ACTG1/COL3A1/VCAN/FBLN1/TPM4/LAMA2/COL1A1/VIM/DIAPH2/SSPN/FN1/ITGB1/LMNA/SYNPO2/ITGAV/ITGA5/NID1/COL4A1/THBS2/FBN1/VCL/ENO1/COL4A2/FBLN2/COL5A1/MYH9/TPM1/ACTB/COL5A2/ZYX/HSPG2/TPM2/SYNE1/SDC3/DTNA/TMOD3/SPTAN1/ATP1B1/FMNL3/THBS3/COL5A3/FHL3	5.87187875202002
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	48/836	248/9376	2.17070535576478	FOS/JUN/ACTG1/HSP90AA1/RPS3/NFKBIA/PAK3/ARPC2/HSP90AB1/TUBB4B/RAB7A/MYC/NFKB1/TUBB3/CXCL8/RAB7B/FLNA/TUBA1C/TCF7/SNX9/RAC1/ANXA2/ACTB/GAPDH/MAP2K2/RIPK2/PLEKHM2/TUBB2A/NCKAP1L/EXOC4/CD14/STX10/TUBB/AKT3/MYD88/PIK3C2A/TCF7L2/BCL2/IL6/DYNC2LI1/ACTR1B/TNFRSF1A/CASP4/PIK3CG/TNFRSF10A/TCF7L1/TNF/AHNAK	5.84582044009375
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	26/836	103/9376	2.83104937984856	FOS/JUN/NFKBIA/NFKB1/CXCL8/IFNGR2/PIK3R1/ADCY1/CFLAR/C1QC/PLCB1/BDKRB2/GNAI3/TGFB1/GNA11/AKT3/GNAO1/MYD88/CD3E/TGFBR2/IL6/TNFRSF1A/ACE/GNA14/PLCB4/TNF	5.84612881634255
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	47/836	253/9376	2.08347674792443	JUN/CD44/ACTG1/RPS27A/MAP1LC3B/NFKBIA/UBC/ARPC2/FOXO1/ITGB1/NFKB1/ITGA5/CXCL8/UBA52/VCL/IL1R1/RAC1/EGFR/PIK3R1/SEPTIN2/ACTN4/ACTB/RBCK1/PLCB1/RIPK2/HK1/PXN/TBK1/CD14/AKT3/CAPN2/RPS6KA5/DOCK1/MYD88/MDM2/BCL2/TNFRSF1A/CASP4/SEPTIN8/PLCB4/GSK3A/GSK3B/TNF/RRAGA/NFKBIB/PRKCE/WIPI1	5.46601551726734
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	40/836	212/9376	2.11609641599711	ACTG1/CALM1/ITGB1/PDGFRB/MAGI3/FGF10/RAC1/EFNA5/EGFR/APBB1IP/KITLG/PRKCA/PIK3R1/MAGI1/P2RY1/ADCY1/ACTB/FGF7/VASP/MAP2K2/PLCB1/IGF1/ENAH/GNAI3/CSF1R/AKT3/ITGB2/GNAO1/VAV1/RAPGEF6/RASSF5/DOCK4/MAGI2/FPR1/PRKD1/IGF1R/PLCB4/ITGAM/VEGFA/RASGRP3	5.14264973154241
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/836	68/9376	3.13368983957219	MYC/NFKB1/TCF7/PIK3R1/ZBTB16/MAP2K2/DUSP6/CSF1R/STAT3/CCND1/CD14/AKT3/BCL2A1/PIM1/TCF7L2/PPARD/PER2/TCF7L1/ITGAM	5.52481067021675
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	23/836	93/9376	2.77367906569944	ACTG1/FYN/VCL/PTPRM/TCF7/RAC1/EGFR/ACTN4/ACTB/SMURF2/PTPRF/TCF7L2/PTPN6/ARHGAP29/TGFBR2/BAIAP2/PTPRB/SNAI1/ERBB2/SNAI2/SMURF1/IGF1R/TCF7L1	5.3781409600005
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	35/836	178/9376	2.20525778183969	SFRP2/JUN/SERPINF1/APCDD1/MYC/PRICKLE2/RSPO3/TLE4/FOSL1/CCND2/TCF7/RAC1/ROR2/TBL1X/MCC/PRKCA/PLCB1/CTNND2/PRICKLE1/CTBP2/SFRP4/CCND1/LZTS2/CSNK1A1/TCF7L2/RUVBL1/NFATC4/PPARD/ROR1/WNT2/PLCB4/ZNRF3/GSK3B/FZD10/TCF7L1	5.07929087630413
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	40/836	216/9376	2.0769094453305	FOS/JUN/SOD2/HSP90AA1/CALM1/NFKBIA/HSP90AB1/NFKB1/CXCL8/HSPA8/ATF4/ERN1/LYN/HSPD1/CXCL2/RAC1/HSPA1A/ICAM1/PRKCA/PIK3R1/XBP1/HSPA1B/PLCB1/STAT3/TBK1/ABCA1/CD14/AKT3/MYD88/VAV1/ABCG1/CXCL1/BCL2/IL6/TNFRSF1A/CYBB/TNFRSF10A/PLCB4/GSK3B/TNF	5.00977436794638
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/836	227/9376	2.02567291275847	CALM1/NFKBIA/GNG4/MYC/NFKB1/ITGAV/CXCL8/CXCL12/ATF4/AKAP13/IL1R1/RAC1/EGFR/PRKCA/PIK3R1/CDK4/ADCY1/PDIA3/MAP2K2/PLCB1/GNG2/GNAI3/CREB5/STAT3/PXN/TBK1/CCND1/GNA11/AKT3/GNAO1/MDM2/IL10RA/CDKN1A/IL6/TNFRSF1A/NFATC4/PTK2B/PLCB4/GSK3B/TNF/VEGFA	4.89434796789694
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/836	78/9376	2.87572077045761	FOS/JUN/CALM1/C1S/ITGB1/NFKB1/ITGA5/CXCL8/C2/C1R/IRF1/C1QC/GNAI3/CD14/IRF8/ITGB2/MYD88/IL6/ITGAM/TNF	5.20451853472855
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/836	112/9376	2.50341763499658	LAMB1/NFKBIA/LAMA2/ITGB1/NFKB1/IFNGR2/HSPA8/LAMC1/HSPA1A/HSPA1B/GNAI3/STAT3/TGFB1/HLA-DOB/AKT3/GNAO1/MYD88/HLA-DQB2/BCL2/IL10RA/TNFRSF1A/PIK3CG/PIK3R5/TNF/NFKBIB	5.0078258762812
Organismal Systems	Immune system	hsa04611	Platelet activation	27/836	126/9376	2.40328092959672	COL1A2/ACTG1/COL3A1/COL1A1/ITGB1/FYN/LYN/APBB1IP/PIK3R1/P2RY1/PRKG1/ADCY1/ACTB/VASP/PLCB1/GP1BB/TBXAS1/GNAI3/SYK/AKT3/PPP1R12A/VWF/FCGR2A/PIK3CG/PIK3R5/RASGRP1/PLCB4	4.96156712170739
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	37/836	200/9376	2.07483253588517	FOS/JUN/ACTG1/RPS3/NFKBIA/PAK3/ARPC2/TUBB4B/ITGB1/NFKB1/FYN/TUBB3/CXCL8/TUBA1C/IL1R1/RAC1/MYH9/ACTB/GAPDH/MYO1E/TUBB2A/NCKAP1L/PTPN11/SEC24A/TUBB/MYD88/PTPN6/BAIAP2/NCL/IL6/FCGR2A/TNFRSF1A/CASP4/TNFRSF10A/ABL1/TNF/NFKBIB	4.80716402917809
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/836	130/9376	2.32933382407067	COL1A2/FOS/JUN/COL3A1/NFKBIA/GNG4/COL1A1/NFKB1/COL4A1/ATF4/COL4A2/EGFR/PRKCA/PIK3R1/ADCY1/MAP2K2/PLCB1/GNG2/GNAI3/CREB5/TGFB1/AKT3/GNAO1/TGFBR2/ARRB1/PLCB4/VEGFA	4.77516770181989
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	21/836	89/9376	2.64630933820762	COL6A1/COL1A2/COL6A2/COL6A3/CD44/TNXB/LAMB1/LAMA2/COL1A1/FN1/ITGB1/ITGAV/ITGA5/COL4A1/THBS2/LAMC1/COL4A2/HSPG2/GP1BB/VWF/THBS3	4.88234611420238
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	39/836	224/9376	1.95266575529733	FOS/JUN/EGR1/SLC25A6/NFKBIA/NRP1/MYC/NFKB1/FOSL1/ATF4/CCND2/IL1R1/ICAM1/PIK3R1/ZFP36/CDK4/ADCY1/PTEN/IL15/MAP2K2/CREB5/TGFB1/HLA-DOB/CCND1/MSX1/MSX2/AKT3/ITGB2/RAN/HLA-DQB2/CHEK1/CD3E/TGFBR2/IL2RG/CDKN1A/IL6/TNFRSF1A/NFATC4/TNF	4.51508987200302
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/836	41/9376	3.55607422102929	TYMP/MYC/CXCL8/EGFR/CDK4/DAPK2/MAP2K2/CCND1/RPS6KA5/MDM2/CDKN1A/ERBB2/VEGFA	5.13178046408035
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	36/836	201/9376	2.00871241876741	NFKBIZ/DDX5/PBX1/GADD45A/FOXO1/MYC/ZEB1/NFKB1/CXCL8/FUS/CEBPB/CCND2/KLF3/MEIS1/ZBTB16/GADD45B/IGF1/PLAT/DUSP6/CSF1R/ID2/JMJD1C/GRIA3/CD14/BCL2A1/MLF1/PBX3/MDM2/TGFBR2/MLLT3/CDKN1A/IL6/PER2/IGF1R/MAF/ITGAM	4.52295431929509
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/836	78/9376	2.73193473193473	EEF1A1/FOS/JUN/NFKBIA/ITGB1/NFKB1/IFNGR2/MARCKSL1/TGFB1/HLA-DOB/ITGB2/MYD88/HLA-DQB2/PTPN6/FCGR2A/CYBB/ITGAM/TNF/NFKBIB	4.80555877786402
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/836	93/9376	2.53248958172557	GADD45A/LAMB1/NFKBIA/LAMA2/FN1/ITGB1/MYC/NFKB1/ITGAV/COL4A1/LAMC1/COL4A2/PIK3R1/CDK4/GADD45B/PTEN/CKS2/CCND1/AKT3/BCL2/CDKN1A	4.64680739015329
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/836	136/9376	2.22656909653814	RACK1/FOS/JUN/NFKBIA/TNFAIP3/NFKB1/CBLB/HSPA8/CCND2/EIF3H/HSPA1A/PIK3R1/CDK4/HSPA1B/STAT3/TBK1/CCND1/MSN/AKT3/MYD88/BCL2/CD3E/IL2RG/IL6/STAT2/GSK3B/NFKBIB	4.50801475212288
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/836	232/9376	1.88533245339053	TMSB4X/GSN/ACTG1/PAK3/ARPC2/DIAPH2/FN1/ITGB1/ITGAV/ITGA5/CXCL12/VCL/PDGFRB/FGF10/RAC1/EGFR/PIK3R1/ACTN4/MYH9/ACTB/FGF7/MAP2K2/ENAH/BDKRB2/BDKRB1/NCKAP1L/PXN/MSN/SLC9A1/AKT3/ITGB2/PPP1R12A/DOCK1/VAV1/PIP4K2A/FGD3/BAIAP2/GIT1/ITGAM	4.27210688268691
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/836	110/9376	2.34501957372771	LDHA/RPS6/NFKB1/IFNGR2/ENO1/EGFR/PRKCA/PIK3R1/GAPDH/MAP2K2/IGF1/HK1/STAT3/AKT3/LDHB/BCL2/CDKN1A/IL6/CYBB/ERBB2/IGF1R/PFKFB3/VEGFA	4.43954682317985
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/836	170/9376	2.04514494793133	ACTG1/GADD45A/MYC/TXNRD1/TCF7/MGST3/EGFR/ARID1B/PRKCA/PIK3R1/CDK4/GADD45B/PTEN/ACTB/MAP2K2/DPF3/TGFB1/CCND1/AKT3/CSNK1A1/TCF7L2/TGFBR2/SMARCA2/CDKN1A/GSTM5/KEAP1/WNT2/IGF1R/GSK3B/FZD10/TCF7L1	4.30254422027102
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	28/836	148/9376	2.12181559549981	FOS/JUN/GADD45A/MYC/TCF7/FGF10/EGFR/PIK3R1/CDK4/GADD45B/PTEN/FGF7/MAP2K2/IGF1/DLL1/CCND1/AKT3/CSNK1A1/TCF7L2/CDKN1A/ERBB2/HES1/WNT2/IGF1R/BRCA1/GSK3B/FZD10/TCF7L1	4.30386241688581
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/836	77/9376	2.62176101410551	GADD45A/NFKBIA/MYC/NFKB1/PIK3R1/CDK4/GADD45B/MAP2K2/CTBP2/PTPN11/TGFB1/CCND1/AKT3/GAB2/MDM2/TGFBR2/CDKN1A/ABL1	4.47068361456809
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/836	105/9376	2.34987468671679	GADD45A/NFKBIA/TNFAIP3/NFKB1/CXCL8/CXCL12/LYN/IL1R1/CXCL2/ICAM1/GADD45B/CFLAR/SYK/CD14/BCL2A1/MYD88/TRIM25/CXCL1/BCL2/TNFRSF1A/EDA/TNF	4.35195758465557
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/836	59/9376	2.85135025545373	GADD45A/MYC/TCF7/EGFR/PIK3R1/GADD45B/PTEN/MAP2K2/CCND1/AKT3/TCF7L2/CDKN1A/ERBB2/GSK3B/TCF7L1	4.46309765967553
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/836	333/9376	1.68398063134905	COL6A1/COL1A2/COL6A2/COL6A3/TNXB/LAMB1/LAMA2/COL1A1/FOXO1/FN1/ITGB1/NFKB1/ITGAV/ITGA5/COL4A1/THBS2/LAMC1/PDGFRB/CCND2/COL4A2/TCF7/EGFR/IRF1/PIK3R1/MAGI1/CDK4/PTEN/MAP2K2/CREB5/PXN/TBK1/CCND1/AKT3/CSNK1A1/CHD4/TCF7L2/MDM2/CDKN1A/VWF/TNFRSF1A/STAT2/HES1/WNT2/THBS3/GSK3B/FZD10/TCF7L1/TNF/VEGFA/TADA3	3.97621167950253
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	40/836	250/9376	1.79444976076555	CAV1/ARPC2/RAB7A/BIN1/CBLB/HSPA8/SH3GL1/SNX6/EGFR/CHMP4B/HSPA1A/PSD3/HSPA1B/ASAP1/IQSEC1/EHD1/FOLR2/SH3KBP1/VPS37B/SMURF2/CLTA/VPS28/EHD2/PSD/ARF5/MDM2/TGFBR2/IL2RG/AMPH/AP2M1/RAB10/GIT1/ZFYVE27/ARRB1/SH3GLB2/SMURF1/IGF1R/ARFGEF1/PSD4/RAB11FIP3	3.98341956653592
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/836	138/9376	2.11302960959712	FOS/JUN/ACTG1/NFKBIA/ARPC2/FN1/ITGB1/NFKB1/ITGA5/CXCL8/RAC1/PIK3R1/ACTB/MAP2K2/PXN/TBK1/AKT3/DOCK1/MYD88/VAV1/BAIAP2/IL6/FCGR2A/PTK2B/GSK3B/TNF	4.12113767933882
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	19/836	87/9376	2.44932079414838	FOS/JUN/GADD45A/MYC/TCF7/RAC1/EGFR/PIK3R1/GADD45B/MAP2K2/TGFB1/CCND1/AKT3/TCF7L2/BCL2/TGFBR2/CDKN1A/GSK3B/TCF7L1	4.24912502413101
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	34/836	205/9376	1.86010036176917	JUN/CD44/GADD45A/NFKBIA/VIM/MYC/TNFAIP3/NFKB1/CCND2/LYN/RAC1/ICAM1/PIK3R1/CDK4/GADD45B/PDIA3/SYK/STAT3/TBK1/HLA-DOB/CCND1/PSMD8/AKT3/MYD88/HLA-DQB2/MDM2/BCL2/CD3E/CDKN1A/IL6/STAT2/HES1/TNF/NFKBIB	3.89562869097876
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	23/836	119/9376	2.16766515218528	FOS/JUN/NFKBIA/JUNB/SOCS3/TNFAIP3/NFKB1/MAP3K8/ATF4/CEBPB/CXCL2/IRF1/ICAM1/PIK3R1/CFLAR/IL15/CREB5/AKT3/RPS6KA5/CXCL1/IL6/TNFRSF1A/TNF	4.01066612355968
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/836	76/9376	2.50868798791236	GADD45A/CALM1/PDGFRB/EGFR/PRKCA/PIK3R1/CDK4/GADD45B/PTEN/MAP2K2/IGF1/CCND1/AKT3/CAMK1D/MDM2/CDKN1A/IGF1R	4.13166019349235
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/836	98/9376	2.2888389805683	GSN/ARPC2/BIN1/LYN/MARCKSL1/MARCKS/RAC1/INPP5D/PRKCA/PIK3R1/ASAP1/VASP/SYK/AKT3/GAB2/DOCK1/VAV1/AMPH/FCGR2A/PRKCE	4.01277083221407
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	20/836	99/9376	2.265719394906	ACTG1/TPM4/LAMA2/CACNB2/SSPN/ITGB1/LMNA/ITGAV/ITGA5/SLC8A1/CACNA1C/TPM1/ACTB/IGF1/TPM2/TGFB1/DTNA/IL6/ACE/TNF	3.96105703220445
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/836	116/9376	2.12704174228675	ACTG1/ITGB1/CXCL12/VCL/RAC1/ICAM1/PRKCA/PIK3R1/ACTN4/ACTB/VASP/GNAI3/PTPN11/PXN/MSN/ITGB2/VAV1/RASSF5/CYBB/PTK2B/JAM2/ITGAM	3.82140743439092
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/836	163/9376	1.92655649161946	FOS/JUN/NFKBIA/MYC/NFKB1/CXCL8/YWHAB/ATF4/PRKCA/PIK3R1/DDX3X/HSPG2/MAP2K2/CREB5/STAT3/TBK1/TGFB1/AKT3/MYD88/BCL2/TGFBR2/CDKN1A/IL6/STAT2/NFATC4/PTK2B/YWHAQ/TNF	3.73357613040965
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/836	73/9376	2.45815035721308	GADD45A/PDGFRB/FGF10/EGFR/PIK3R1/CDK4/GADD45B/PTEN/FGF7/MAP2K2/IGF1/CCND1/AKT3/MDM2/CDKN1A/IGF1R	3.91302001881021
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/836	157/9376	1.9287477524152	GADD45A/CALM1/SLC25A6/ZFP36L2/ZFP36L1/FOXO1/MYC/NFKB1/CXCL8/CCND2/PIK3R1/CDK4/GADD45B/MAPKAPK2/PTEN/MAP2K2/TGFB1/CCND1/AKT3/CAPN2/CHEK1/RASSF5/MDM2/TGFBR2/CDKN1A/IL6/NFATC4	3.67168602115715
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/836	142/9376	1.97452658534942	FOS/JUN/NFKBIA/FOSB/JUNB/SOCS3/JUND/NFKB1/FYN/IFNGR2/FOSL1/IL1R1/RAC1/PIK3R1/CSF1R/SYK/TGFB1/AKT3/GAB2/TREM2/TGFBR2/FCGR2A/TNFRSF1A/STAT2/TNF	3.66102563553963
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/836	90/9376	2.24306220095694	FOS/JUN/NFKBIA/NFKB1/IFNGR2/EGFR/PIK3R1/PTEN/MAP2K2/STAT3/PTPN11/AKT3/EML4/MYD88/PTPN6/CD3E/RASGRP1/NFKBIB	3.70731610027917
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/836	144/9376	1.94710260499734	NFKBIA/FOXO1/NFKB1/CXCL8/C2/CXCL2/TCF7/C1QC/TRA2A/ALDH9A1/TBK1/CCND1/CD14/AKT3/MYD88/C3AR1/TCF7L2/CXCL1/IL6/TNFRSF1A/ADH5/SCD5/GSK3B/TCF7L1/TNF	3.58335817962109
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/836	137/9376	1.96472601543673	FOS/JUN/ACTG1/MCL1/GADD45A/NFKBIA/LMNA/NFKB1/ATF4/ERN1/TUBA1C/PIK3R1/GADD45B/ACTB/CFLAR/MAP2K2/AKT3/BCL2A1/CAPN2/BCL2/SPTAN1/TNFRSF1A/TNFRSF10A/TNF	3.55886596466604
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/836	70/9376	2.40328092959672	ACTG1/LAMA2/CAV1/ABL2/SSPN/FYN/RAC1/ICAM1/ACTB/HLA-DOB/CCND1/ITGB2/HLA-DQB2/DTNA/ABL1	3.686990008758
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	30/836	187/9376	1.79924775477829	JUN/HSP90AA1/MAP1LC3B/NFKBIA/HSP90AB1/TNFAIP3/NFKB1/CXCL8/CXCL2/GBP1/IFI16/RBCK1/PLCB1/RIPK2/GBP3/TBK1/TRIP6/CARD16/MYD88/CXCL1/BCL2/SUGT1/IL6/STAT2/CYBB/CASP4/PLCB4/PANX1/TNF/NFKBIB	3.45404462360523
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	26/836	155/9376	1.88127797499614	ACTG1/TUBB4B/RAB7A/ITGB1/ITGAV/ITGA5/TUBB3/RAB7B/THBS2/TUBA1C/C1R/MSR1/RAC1/ACTB/TUBB2A/HLA-DOB/MRC1/CD14/CLEC7A/TUBB/ITGB2/HLA-DQB2/FCGR2A/CYBB/THBS3/ITGAM	3.4613825184809
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/836	50/9376	2.69167464114832	LRP1/CXCL8/THBS2/GYPC/ICAM1/TGFB1/ITGB2/MYD88/IL6/HBB/THBS3/TNF	3.75244190538075
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	26/836	157/9376	1.8573126504739	PBX1/LRP1/RAB7A/ITGAV/RAB7B/SLC16A1/CEBPB/DUSP16/RAC1/MAPKAPK2/C1QC/MAP2K2/STAB1/DUSP2/PTPN11/TGFB1/ABCA1/ATP8A1/DUSP5/DOCK1/PTPN6/CX3CR1/NFATC4/PPARD/CD24/PANX1	3.38927643843057
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/836	94/9376	2.14761274559707	FOS/JUN/HSP90AA1/NFKBIA/FOSB/JUND/HSP90AB1/TNFAIP3/NFKB1/CXCL8/FOSL1/CEBPB/CXCL2/TBK1/CXCL1/IL6/GSK3B/TNF	3.49863268652439
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	33/836	217/9376	1.7055542081009	FOS/JUN/CYP1B1/HSP90AA1/KLF4/HSP90AB1/MYC/NFKB1/ATF4/FGF10/MGST3/KPNA2/EGFR/CACNA1C/PTGES3/PRKCA/PIK3R1/ADCY1/FGF7/MAP2K2/AHR/GNAI3/AR/CREB5/STAT3/DLL1/CCND1/AKT3/KPNB1/BCL2/GSTM5/ARRB1/VEGFA	3.29000126878909
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/836	142/9376	1.89554552193544	FOS/JUN/ACTG1/HSP90AA1/CALM1/DUSP1/CAV1/HSP90AB1/NFKB1/ITGAV/IL1R1/RAC1/MGST3/ICAM1/PIK3R1/ACTB/PLAT/AKT3/BCL2/TNFRSF1A/GSTM5/KEAP1/TNF/VEGFA	3.36431572302649
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/836	80/9376	2.24306220095694	RPS6/PDGFRB/EGFR/PRKCA/PIK3R1/PTEN/MAP2K2/IGF1/STAT3/AKT3/BCL2/IL6/ERBB2/IGF1R/GSK3B/VEGFA	3.49341063609511
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/836	73/9376	2.30451595988726	GADD45A/EGFR/PRKCA/PIK3R1/CDK4/GADD45B/MAP2K2/STAT3/CCND1/AKT3/EML4/RASSF5/CDKN1A/ERBB2/STK4	3.50073436572929
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	19/836	105/9376	2.02943722943723	ACTG1/TPM4/LAMA2/CACNB2/SSPN/ITGB1/LMNA/ITGAV/ITGA5/SLC8A1/CACNA1C/ADCY1/TPM1/ACTB/IGF1/TPM2/TGFB1/DTNA/TNF	3.31887633916058
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	25/836	154/9376	1.82066737090661	FOS/JUN/ACTG1/EEF2/CALM1/MYL6/CACNB2/EGFR/CACNA1C/PRKCA/ADCY1/ACTB/MAP2K2/PLCB1/GNAI3/CCND1/PPP1R12A/GNAO1/CAMK1D/CD38/CDKN1A/PIK3CG/NFATC4/PIK3R5/PLCB4	3.21273429744656
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	20/836	115/9376	1.95048887039734	FOS/EGR1/NACA/JUND/ATF4/AKAP13/EGFR/PRKCA/ADCY1/PLCB1/GNAI3/CREB5/MMP17/GNA11/KL/BCL2/CDKN1A/ARRB1/PLCB4/STK39	3.20868331206394
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/836	173/9376	1.75036645739414	ACTG1/SLC25A6/NFKBIA/SOCS3/DNAJB1/NFKB1/CXCL8/IFNGR2/KPNA2/ICAM1/PRKCA/PIK3R1/CDK4/ACTB/MAP2K2/TBK1/HLA-DOB/AKT3/MYD88/HLA-DQB2/TRIM25/IL6/TNFRSF1A/STAT2/TNFRSF10A/TNF/NFKBIB	3.11667555180815
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/836	77/9376	2.18480084508793	GADD45A/NFKB1/RAC1/EGFR/PIK3R1/CDK4/GADD45B/STAT3/TGFB1/CCND1/AKT3/TGFBR2/CDKN1A/ERBB2/VEGFA	3.26612224525728
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/836	166/9376	1.75661497665302	CALM1/SLC25A6/SLC8A1/ATF4/ADRA2C/CACNA1C/PRKG1/ADCY1/VASP/MAP2K2/PLCB1/ATP2B1/BDKRB2/GNAI3/CREB5/GNA11/AKT3/PPP1R12A/PDE3A/GTF2I/ATP1B1/PIK3CG/NFATC4/PIK3R5/PLCB4/PRKCE	3.07722324285549
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/836	133/9376	1.85516422635536	SOD2/GADD45A/FOXO1/PLK2/CCND2/EGFR/PIK3R1/GADD45B/PTEN/MAP2K2/IGF1/STAT3/TGFB1/CCND1/AKT3/MDM2/TGFBR2/PRMT1/CDKN1A/IL6/IGF1R/STK4	3.10762574369313
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/836	109/9376	1.95496246872394	FOS/JUN/HSP90AA1/RORA/NFKBIA/HSP90AB1/NFKB1/IFNGR2/IL1R1/AHR/STAT3/TGFB1/HLA-DOB/HLA-DQB2/CD3E/TGFBR2/IL2RG/IL6/NFKBIB	3.13754391085751
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/836	109/9376	1.95496246872394	NFKBIA/SLC27A4/GFPT2/SOCS3/FOXO1/NFKB1/PIK3R1/PTEN/CREB5/STAT3/PTPN11/MLXIP/AKT3/PTPRF/IL6/TNFRSF1A/GSK3B/TNF/PRKCE	3.13754391085751
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/836	78/9376	2.15679057784321	ACTG1/CAV1/ARPC2/FN1/ITGB1/ITGA5/VCL/RAC1/PIK3R1/SEPTIN2/ACTB/PXN/CLTA/DOCK1/SEPTIN8	3.20971975040588
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/836	110/9376	1.93719008264463	ID4/MYC/FBN1/THSD4/NBL1/FMOD/BMP8B/ID2/SMURF2/TGFB1/BMP2/TGFBR2/GDF7/TFDP1/SMURF1/LEMD3/SKI/TGIF1/TNF	3.09341167622512
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/836	238/9376	1.60218728639781	CALM1/PAK3/GNG4/ABL2/NFKB1/PDGFRB/FGF10/RAC1/EFNA5/EGFR/KITLG/PRKCA/PIK3R1/FLT3LG/FGF7/RALGAPA2/MAP2K2/IGF1/GNG2/CSF1R/PTPN11/TBK1/AKT3/RASAL3/GAB2/RASAL2/RASSF5/IGF1R/RASGRP1/ABL1/RALGAPA1/STK4/VEGFA/RASGRP3	2.94411198716154
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/836	37/9376	2.72804862278547	ICAM1/PRKCA/APOL1/PLCB1/MYD88/IL6/HBB/PLCB4/TNF	3.29508387712181
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/836	37/9376	2.72804862278547	GADD45A/MYC/TCF7/GADD45B/MAP2K2/CCND1/TCF7L2/CDKN1A/TCF7L1	3.29508387712181
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/836	88/9376	2.0391474554154	CFD/C1S/SERPINE2/PROCR/C2/C1R/C1QC/PLAT/BDKRB2/BDKRB1/ITGB2/C3AR1/F13A1/VWF/VSIG4/ITGAM	3.06420101971598
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/836	120/9376	1.86921850079745	JUN/CALM1/NFKBIA/NFKB1/ATF4/IRAK3/RAC1/PIK3R1/MAPKAPK2/MAP2K2/RIPK2/PTPN11/AKT3/RPS6KA5/BCL2/SH2B3/BEX3/ABL1/GSK3B/NFKBIB	2.99824938363556
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/836	122/9376	1.83857557455487	FOS/JUN/NFKBIA/PAK3/NFKB1/FYN/MAP3K8/CBLB/PIK3R1/CDK4/MAP2K2/PTPN11/AKT3/VAV1/PTPN6/CD3E/RASGRP1/GSK3B/TNF/NFKBIB	2.91687096700581
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/836	122/9376	1.83857557455487	ACTG1/FOXO1/MYC/ITGAV/MED13L/PRKCA/PIK3R1/ACTB/MAP2K2/PLCB1/CCND1/SLC9A1/MED13/AKT3/DIO2/MDM2/ATP1B1/MED14/PLCB4/GSK3B	2.91687096700581
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/836	122/9376	1.83857557455487	FOS/JUNB/SOCS3/ATF4/CSH1/CACNA1C/SOCS2/PRKCA/PIK3R1/ADCY1/MAP2K2/PLCB1/IGF1/GNAI3/CREB5/STAT3/GNA11/AKT3/PLCB4/GSK3B	2.91687096700581
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/836	75/9376	2.09352472089314	GADD45A/CCND2/CDK4/GADD45B/PTEN/IGF1/CCND1/ZNF385A/CHEK1/MDM2/BCL2/CDKN1A/TNFRSF10A/SESN2	2.97477591426102
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/836	60/9376	2.24306220095694	LYN/PRKCA/PRKG1/MAP2K2/PLCB1/IGF1/GNAI3/GRIA3/GNA11/GNAO1/IGF1R/PLCB4	3.02213309966949
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/836	115/9376	1.85296442687747	FOS/GNG4/FYN/ATF4/CACNA1C/PRKCA/PIK3R1/ADCY1/PLCB1/GNG2/GNAI3/CREB5/GNA11/AKT3/GNAO1/BCL2/PIK3CG/PIK3R5/PLCB4	2.87945793743151
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	16/836	91/9376	1.97192281402808	FOS/JUN/NFKBIA/NFKB1/LYN/RAC1/INPP5D/PIK3R1/MAP2K2/SYK/AKT3/VAV1/PTPN6/GSK3B/NFKBIB/RASGRP3	2.91488456251988
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/836	193/9376	1.62709175198949	NFKBIA/GNG4/NFKB1/CXCL8/CXCL12/LYN/CXCL2/RAC1/PIK3R1/ADCY1/PLCB1/GNG2/GNAI3/STAT3/PXN/AKT3/VAV1/CXCL1/STAT2/CX3CR1/PIK3CG/ARRB1/PTK2B/PIK3R5/PLCB4/GSK3A/GSK3B/NFKBIB	2.75408469992777
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/836	150/9376	1.71968102073365	GADD45A/MYC/TCF7/FGF10/EGFR/PIK3R1/GADD45B/FGF7/MAP2K2/TGFB1/CCND1/AKT3/CSNK1A1/ABCB1/TCF7L2/BCL2/TGFBR2/CDKN1A/ERBB2/WNT2/GSK3B/FZD10/TCF7L1	2.77996159167648
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/836	125/9376	1.79444976076555	NFKB1/FYN/S1PR3/RAC1/PRKCA/PIK3R1/PTEN/MAP2K2/PLCB1/BDKRB2/GNAI3/S1PR2/AKT3/GAB2/BCL2/TNFRSF1A/CERS2/PLCB4/TNF/PRKCE	2.79760854748911
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/836	168/9376	1.66894508999772	MCL1/AOX1/SOCS3/MYC/IFNGR2/PDGFRB/CCND2/CSH1/EGFR/SOCS2/PIK3R1/IL15/STAT3/PTPN11/CCND1/AKT3/PIM1/PTPN6/BCL2/IL2RG/IL10RA/CDKN1A/IL6/STAT2/TSLP	2.73729937043303
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/836	21/9376	3.20437457279563	CHST15/DSEL/CHSY3/XYLT1/UST/DSE	3.16397458173572
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/836	86/9376	1.95615889618338	ACTG1/LAMA2/CACNB2/SSPN/ITGB1/LMNA/ITGAV/ITGA5/SLC8A1/TCF7/CACNA1C/ACTB/DTNA/TCF7L2/TCF7L1	2.7869634959687
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/836	71/9376	2.05350764876339	FOS/SOCS3/NFKB1/CGA/CCND2/IRF1/SOCS2/PIK3R1/MAP2K2/STAT3/CCND1/AKT3/GSK3B	2.7878443342073
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/836	71/9376	2.05350764876339	LDHA/MYC/PDGFRB/EGFR/PIK3R1/PTEN/GLS/MAP2K2/HK1/AKT3/SLC7A5/LDHB/ERBB2	2.7878443342073
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/836	103/9376	1.85107074836252	COL6A1/COL1A2/COL6A2/COL6A3/COL15A1/COL3A1/COL1A1/COL4A1/SLC8A1/COL4A2/COL18A1/COL5A1/COL5A2/COL21A1/ACE2/ATP1B1/COL5A3	2.71727747023396
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/836	180/9376	1.61998936735779	NFKBIA/SOCS3/SRSF5/PILRA/NFKB1/ITGA5/IFNGR2/PIK3R1/PDIA3/SRSF7/SRSF3/SYK/PTPN11/TBK1/HLA-DOB/SRSF6/AKT3/MYD88/HLA-DQB2/BCL2/IL6/TNFRSF1A/STAT2/EIF2B4/TNFRSF14/TNF	2.62773069619796
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/836	56/9376	2.20300751879699	CCND2/SCUBE2/BOC/SMURF2/CCND1/CUL3/CSNK1A1/BCL2/ARRB1/SMURF1/GSK3B	2.82497260472859
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	26/836	181/9376	1.61103914985857	CALM1/RAB7A/NFKB1/IFNGR2/CEBPB/HSPD1/RIPK2/SYK/TGFB1/HLA-DOB/MRC1/CD14/CLEC7A/AKT3/ITGB2/MYD88/HLA-DQB2/BCL2/IL10RA/HSPA9/IL6/FCGR2A/TLR1/TNFRSF1A/ITGAM/TNF	2.59712168838965
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/836	155/9376	1.66420743941966	PBX1/PDE8B/ATF4/NR4A1/TCF7/EGFR/CACNA1C/CDK4/ADCY1/MAP2K2/PLCB1/AHR/GNAI3/CREB5/CCND1/GNA11/TCF7L2/CDKN1A/WNT2/PLCB4/GSK3B/FZD10/TCF7L1	2.60879777400797
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/836	105/9376	1.81581225791752	JUN/RPS27A/MAP1LC3B/UBC/RABGEF1/RAB7A/RAB7B/ARIH1/UBA52/ATF4/OPTN/VCP/AMBRA1/SMURF2/TBK1/TOMM7/SMURF1	2.63015550883059
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/836	105/9376	1.81581225791752	JUN/CALM1/NFKBIA/NFKB1/CBLB/IRF1/PIK3R1/MAPKAPK2/SYK/PTPN11/CLEC7A/AKT3/MDM2/IL6/STAT2/NFATC4/TNF	2.63015550883059
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/836	89/9376	1.89022095586259	TUBB4B/TUBB3/PDGFRB/TUBA1C/EGFR/PRKCA/PRKG1/ADCY1/MAP2K2/PLCB1/GNAI3/TUBB2A/GNA11/TUBB/PLCB4	2.64006692045447
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/836	157/9376	1.64300734464999	ACTG1/MYC/YWHAB/CCND2/TCF7/SAV1/ACTB/BMP8B/ID2/TGFB1/CCND1/STK3/ITGB2/BMP2/TCF7L2/TGFBR2/GDF7/SNAI2/YWHAQ/WNT2/GSK3B/FZD10/TCF7L1	2.54204769025085
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/836	66/9376	2.0391474554154	JUN/RORA/NFKB1/IFNGR2/STAT3/TGFB1/HLA-DOB/HLA-DQB2/IL2RG/IL6/MAF/TNF	2.65053868582711
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/836	99/9376	1.8125755159248	FOS/JUN/EGFR/PIK3R1/CDK4/ADCY1/MAP2K2/IGF1/DLL1/CCND1/AKT3/MDM2/BCL2/CDKN1A/ERBB2/IGF1R	2.54294749255235
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	29/836	214/9376	1.51983186513437	FOS/JUN/CALM1/NFKBIA/PAK3/GNG4/NFKB1/RAC1/PRKCA/PIK3R1/PDIA3/MAP2K2/GNG2/GNAI3/PXN/TBK1/GNA11/AKT3/GNAO1/MYD88/CHEK1/AP1S2/BCL2/CD3E/TNFRSF1A/DCAF1/NFATC4/PTK2B/TNF	2.40676940621091
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/836	169/9376	1.59270688825345	RPS27A/MAP1LC3B/UBC/RAB7A/RAB7B/UBA52/ERN1/IGBP1/OPTN/PIK3R1/PTEN/CFLAR/DAPK2/MAP2K2/AMBRA1/NRBF2/TBK1/AKT3/BCL2/MTMR3/EPG5/IGF1R/RRAGA/WIPI1	2.43267502680075
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/836	100/9376	1.79444976076555	CD44/ITGA5/IL1R1/KITLG/FLT3LG/GP1BB/CSF1R/HLA-DOB/CD14/HLA-DQB2/CD3E/CD38/IL6/CD24/ITGAM/TNF	2.4988829289503
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/836	109/9376	1.74917694570036	FOS/JUN/NFKBIA/NFKB1/MAP3K8/CXCL8/RAC1/PIK3R1/MAP2K2/TBK1/CD14/AKT3/MYD88/IL6/TLR1/STAT2/TNF	2.46143240296967
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	16/836	101/9376	1.77668293145104	CALM1/TCF7/KITLG/PRKCA/ADCY1/MAP2K2/PLCB1/GNAI3/GNAO1/TCF7L2/WNT2/PLCB4/ASIP/GSK3B/FZD10/TCF7L1	2.45531564117619
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/836	53/9376	2.11609641599711	SLC8A1/PRKCA/PLCB1/ATP2B1/BDKRB2/CLTA/KL/AP2M1/ATP1B1/PLCB4	2.54930411968833
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/836	69/9376	1.95048887039734	FYN/LYN/RAC1/INPP5D/PRKCA/PIK3R1/MAP2K2/SYK/AKT3/GAB2/VAV1/TNF	2.47928564532934
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/836	154/9376	1.60218728639781	CALM1/TPM4/CACNB2/SLC8A1/ATF4/CACNA1C/PRKCA/ADCY1/TPM1/PLCB1/ATP2B1/GNAI3/CREB5/TPM2/SLC9A1/AKT3/RPS6KA5/BCL2/ATP1B1/PIK3CG/PIK3R5/PLCB4	2.35743227656202
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/836	86/9376	1.82574830310448	JUN/PAK3/ABL2/MYC/CBLB/EGFR/PRKCA/PIK3R1/MAP2K2/AKT3/CDKN1A/ERBB2/ABL1/GSK3B	2.40684930799298
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	15/836	95/9376	1.77083857970285	FOS/JUN/CXCL8/CXCL12/CXCL2/ICAM1/IL15/TGFB1/HLA-DOB/ITGB2/HLA-DQB2/CXCL1/IL6/TNF/VEGFA	2.36258640411437
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/836	139/9376	1.61371381363808	FOS/JUN/HSP90AA1/CALM1/HSP90AB1/HSPA8/ATF4/EGFR/HSPA1A/PIK3R1/HSPA1B/ADCY1/MAP2K2/PLCB1/GNAI3/CREB5/AKT3/GNAO1/BCL2/PLCB4	2.28069740545136
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/836	71/9376	1.89554552193544	JUN/NFKBIA/NFKB1/CXCL8/LYN/CXCL2/RAC1/EGFR/PTPN11/CXCL1/GIT1/JAM2	2.36983709827165
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/836	149/9376	1.58068141678173	FYN/CXCL8/PDGFRB/EGFR/KITLG/PRKCA/PIK3R1/ADCY1/MAP2K2/PLCB1/DGKI/SYK/PTPN11/AKT3/GAB2/DGKD/AGPAT3/PIK3CG/PTK2B/PIK3R5/PLCB4	2.23542777783226
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/836	97/9376	1.73432644403887	FOS/CALM1/GNG4/CACNA1C/PRKCA/PRKG1/ADCY1/PLCB1/GNG2/GNAI3/GRIA3/GNAO1/RPS6KA5/PER2/PLCB4	2.27449134901573
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/836	98/9376	1.71662923542623	CALM1/ATF4/NR4A1/CACNA1C/PRKCA/ADCY1/PLCB1/ATP2B1/CREB5/GNA11/CAMK1D/ATP1B1/PRKD1/PLCB4/PRKCE	2.23120881412372
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/836	65/9376	1.89797570850202	TRPC4/CGA/CACNA1C/PRKCA/PIK3R1/MAP2K2/PLCB1/GNA11/AKT3/ARRB1/PLCB4	2.27291369353691
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/836	99/9376	1.6992895461795	CFD/C1S/C2/C1R/ICAM1/C1QC/HLA-DOB/ITGB2/HLA-DQB2/C3AR1/FPR3/FCGR2A/FPR1/PTAFR/ITGAM	2.18842010763932
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/836	93/9376	1.68832638781705	JUN/EGR1/CALM1/CGA/ATF4/EGFR/CACNA1C/PRKCA/ADCY1/MAP2K2/PLCB1/GNA11/PTK2B/PLCB4	2.08713989568808
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/836	156/9376	1.50975340449025	NFKBIA/SOCS3/MYC/EIF3E/NFKB1/YWHAB/EGFR/PIK3R1/CDK4/CFLAR/MAP2K2/STAT3/TBK1/CCND1/AKT3/CDKN1A/TNFRSF1A/STAT2/YWHAQ/GSK3B/TNF	2.00870802769826
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/836	184/9376	1.462866652798	PAK3/TRPC4/NRP1/ITGB1/FYN/CXCL12/SEMA5A/BOC/RAC1/EFNA5/SRGAP3/PRKCA/PIK3R1/ENAH/GNAI3/PTPN11/ABLIM1/EFNB1/GDF7/NTNG2/SEMA4B/NFATC4/ABL1/GSK3B	1.98389936505357
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/836	157/9376	1.50013714076738	FOS/JUN/SOCS3/NFKB1/COX4I1/CXCL8/MT-CO3/ATF4/ERN1/RAC1/NDUFS5/PIK3R1/XBP1/TGFB1/MLXIP/AKT3/IL6/TNFRSF1A/GSK3A/GSK3B/TNF	1.9772285247977
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/836	69/9376	1.78794813119756	FOS/JUN/CALM1/FOSB/ATF4/ARC/CACNA1C/PRKCA/CREB5/GRIA3/SLC18A2	2.05530916961241
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/836	205/9376	1.42242968841172	JUN/GSN/NFKBIA/NFKB1/YWHAB/ATF4/CCND2/LYN/RAC1/PIK3R1/CDK4/ACTN4/MAPKAPK2/DDX3X/GTF2B/CREB5/SYK/STAT3/PXN/CCND1/SND1/CHD4/CHEK1/MDM2/CDKN1A/YWHAQ	1.91329906048749
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/836	140/9376	1.52207792207792	EGR1/RPS6/MAP1LC3B/CALM1/GNG4/SLC8A1/ADCY1/MAP2K2/PLCB1/PLAT/GNG2/GNAI3/CCND1/SLC9A1/AKT3/PIK3CG/PIK3R5/PLCB4/PRKCE	1.94722988032087
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/836	70/9376	1.76240601503759	NFKBIA/SOCS3/NFKB1/STAT3/PTPN11/AKT3/TNFRSF1A/ACSL4/ACSL1/TNF/NFKBIB	2.00315083086638
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/836	62/9376	1.80892112980398	SOD2/FOXO1/HSPA8/HSPA1A/PIK3R1/HSPA1B/ADCY1/IGF1/AKT3/IGF1R	1.99937266063724
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/836	170/9376	1.45139318885449	JUN/ACTG1/RAB13/ARPC2/MYL6/ITGB1/YBX3/TUBA1C/RAC1/MAGI1/CDK4/ACTN4/MYH9/ACTB/VASP/CCND1/MSN/RAPGEF6/ERBB2/JAM2/AMOTL1/PRKCE	1.85824861864347
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/836	133/9376	1.5178616397453	FOS/CALM1/GNG4/ATF4/CACNA1C/PRKCA/PLCB1/GNG2/GNAI3/CREB5/GRIA3/AKT3/GNAO1/ARRB1/PLCB4/GSK3A/GSK3B/SLC18A2	1.88188433723708
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/836	63/9376	1.78020809599757	GADD45A/TCF7/GADD45B/BMP2/TCF7L2/CDKN1A/WNT2/GSK3B/FZD10/TCF7L1	1.94399779225286
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	14/836	98/9376	1.60218728639781	CALM1/INPP5D/PRKCA/PIK3R1/PTEN/PLCB1/DGKI/PIP4K2A/PIK3C2A/DGKD/INPP4B/MTMR3/PLCB4/PI4KA	1.87489641050566
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/836	82/9376	1.64126502509044	HSP90AA1/HSP90AB1/HSPA8/HSPA1A/HSPA1B/PDIA3/PSME1/HLA-DOB/HLA-DQB2/LGMN/IFI30/TNF	1.82474838363536
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/836	65/9376	1.72543246227457	PBX1/PDE8B/ATF4/NR4A1/CACNA1C/ADCY1/PLCB1/CREB5/GNA11/PLCB4	1.83618037952342
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	37/836	323/9376	1.28472602841187	CD44/CYP1B1/MCL1/TNXB/VIM/MYC/ZEB1/NFKB1/ITGA5/PDGFRB/CCND2/MARCKS/EFNA5/EGFR/PRKCA/PIK3R1/ZEB2/PTEN/TPM1/GLS/MAP2K2/ZFPM2/STAT3/CCND1/PDCD4/ABCB1/RPS6KA5/PIM1/MDM2/BCL2/CDKN1A/SOX4/ERBB2/BRCA1/ABL1/VEGFA/PRKCE	1.62926606828571
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/836	93/9376	1.56773164583012	CST3/CALM1/PRKCA/PRKG1/ADCY1/PLCB1/ATP2B1/LYZ/SLC9A1/CD38/PRH1/ATP1B1/PLCB4	1.72147311076448
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/836	76/9376	1.62326869806094	UBC/SLC27A4/PLIN2/DBI/ME3/GK/FADS2/SCD5/PPARD/ACSL4/ACSL1	1.70687013501812
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/836	142/9376	1.42165914145158	RPS27A/UBC/SOCS3/UBE2S/CBLB/UBA52/SMURF2/CUL3/MDM2/UBE2E1/RHOBTB1/UBA6/UBE2C/FANCL/KEAP1/SMURF1/UBE2Q2/BRCA1	1.58405624794768
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/836	60/9376	1.6822966507177	RAC1/PRKCA/PIK3R1/MAPKAPK2/MAP2K2/PXN/AKT3/HSPB1/VEGFA	1.65879976910265
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/836	78/9376	1.58164642375169	BTG1/PABPC1/ENO1/PABPC4/HSPD1/TOB2/BTG2/LSM7/HSPA9/CNOT9/CNOT6L	1.61388072294775
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/836	144/9376	1.40191387559809	RORA/SLC25A6/PSMA7/ERN1/PRKCA/PIK3R1/XBP1/GTF2B/PLCB1/AMBRA1/NRBF2/GRIA3/PSMD8/AKT3/PUM1/KCND3/PLCB4/WIPI1	1.52063922750129
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/836	70/9376	1.60218728639781	JUN/PAK3/RAC1/PIK3R1/MAP2K2/PTPN11/TGFB1/AKT3/CDKN1A/VEGFA	1.58219103639347
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/836	44/9376	1.78425402348847	TAF13/GTF2B/TAF4B/TAF7/GTF2I/TAF3/GTF2F2	1.63138163953586
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/836	20/9376	2.24306220095694	UAP1/UGP2/NPL/GMDS	1.74109550165908
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/836	90/9376	1.49537480063796	SOD2/FOXO1/NFKB1/ATF4/PIK3R1/ADCY1/IGF1/CREB5/AKT3/KL/IGF1R/SESN2	1.47740875127882
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/836	100/9376	1.45799043062201	CXCL8/CXCL12/CXCL2/CSF1R/CXCL1/IL2RG/IL10RA/IL6/TNFRSF1A/CX3CR1/TNFRSF10A/TNFRSF14/TNF	1.44057500577646
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/836	37/9376	1.81869908185698	GFPT2/UAP1/UGP2/HK1/GMDS/GPI	1.56111472169858
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/836	91/9376	1.47894211052106	PDE8B/GNG4/PDE10A/GABRA2/PRKCA/ADCY1/PDE7A/GNG2/GNAI3/GNAO1/PDE3A/ARRB1	1.43639077522281
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/836	227/9376	1.28457306662732	FOS/JUN/SOD2/CYP1B1/SLC25A6/NFKBIA/ABL2/NFKB1/COX4I1/MT-CO3/RAC1/MGST3/EGFR/NDUFS5/PIK3R1/PTEN/MT-ND1/MAP2K2/AHR/PTPN11/AKT3/GSTM5/KEAP1/PRKD1/ABL1/VEGFA	1.35793740191481
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/836	158/9376	1.34867663981588	RPS6/EIF4B/PRKCA/PIK3R1/PTEN/MAP2K2/IGF1/AKT3/SLC7A5/TNFRSF1A/MAPKAP1/WNT2/IGF1R/SESN2/GSK3B/FZD10/TNF/RRAGA/FNIP1	1.38290671427114
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/836	47/9376	1.67036546879772	SOCS3/CACNA1C/SOCS2/PIK3R1/HK1/TNF/PRKCE	1.44146087584405
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/836	93/9376	1.44713690384319	FOS/JUN/NFKBIA/NFKB1/IFNGR2/DLL1/HLA-DOB/HLA-DQB2/CD3E/IL2RG/MAF/NFKBIB	1.35580632584088
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/836	22/9376	2.0391474554154	ALDH9A1/CNDP2/CARNMT1/HNMT	1.52668584051622
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/836	75/9376	1.49537480063796	REV3L/MGST3/PIK3R1/AKT3/MDM2/BCL2/CDKN1A/ERBB2/GSTM5/BRCA1	1.34759552967953
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/836	133/9376	1.34921034644026	FYN/IFNGR2/RAC1/ICAM1/PRKCA/PIK3R1/MAP2K2/SYK/PTPN11/ITGB2/VAV1/PTPN6/SH2D1B/PTK2B/TNFRSF10A/TNF	1.26901363400905
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	50/836	480/9376	1.16826156299841	RPS27A/MAP1LC3B/CALM1/SLC25A6/UBC/TUBB4B/NFKB1/PSMA7/COX4I1/TUBB3/MT-CO3/UBA52/FUS/ATF4/ERN1/TUBA1C/IFT57/RAC1/OPTN/CACNA1C/NDUFS5/PRKCA/XBP1/VCP/PRNP/MT-ND1/APP/MAP2K2/PLCB1/AMBRA1/TUBB2A/NRBF2/TBK1/GRIA3/TUBB/PSMD8/CSNK1A1/CAPN2/BCL2/IL6/ACTR1B/TNFRSF1A/CYBB/WNT2/PLCB4/HTT/GSK3B/FZD10/TNF/WIPI1	1.18404441042034
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/836	76/9376	1.47569881641904	ACTG1/CALM1/PRKCA/ADCY1/ACTB/PLCB1/GNAI3/SLC9A1/ATP1B1/PLCB4	1.30273845860575
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/836	144/9376	1.32402977139819	ID4/KLF4/MYC/TCF7/PIK3R1/MEIS1/MAP2K2/IGF1/STAT3/ID2/JARID2/PCGF5/AKT3/WNT2/IGF1R/GSK3B/FZD10	1.22596509148417
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/836	49/9376	1.60218728639781	JUN/FOSB/NFKB1/ATF4/GNAI3/CREB5/SLC18A2	1.32226491799206
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/836	174/9376	1.28911620744652	HSP90AA1/DNAJA1/DNAJB1/HSP90AB1/UBXN1/HSPA8/ATF4/ERN1/HSPA1A/PPP1R15A/XBP1/VCP/HSPA1B/HERPUD1/PDIA3/SEC24A/CAPN2/ERO1B/BCL2/UGGT2	1.20438625232762
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	30/836	275/9376	1.22348847324924	EGR1/SLC25A6/CAV1/TUBB4B/FYN/PSMA7/COX4I1/TUBB3/MT-CO3/HSPA8/LAMC1/ATF4/TUBA1C/RAC1/HSPA1A/CACNA1C/NDUFS5/PIK3R1/HSPA1B/PRNP/C1QC/MT-ND1/CREB5/TUBB2A/TUBB/PSMD8/IL6/CYBB/GSK3B/TNF	1.17689240446029
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/836	15/9376	2.24306220095694	ST6GALNAC5/ST6GALNAC6/ST6GALNAC4	1.50743019093166
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/836	205/9376	1.25830318590267	COL1A2/COL3A1/SLC25A6/GFPT2/COL1A1/NFKB1/COX4I1/MT-CO3/RAC1/NDUFS5/PRKCA/PIK3R1/PTEN/GAPDH/MT-ND1/PLCB1/TGFB1/AKT3/TGFBR2/ACE/CYBB/PLCB4/GSK3B	1.16992544905327
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/836	78/9376	1.43786038522881	INPP5D/PTEN/PLCB1/PIP4K2A/PIK3C2A/INPP4B/MTMR3/PIK3CG/PLCB4/PI4KA	1.21492096608321
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/836	42/9376	1.60218728639781	MAP1LC3B/PRNP/PCBP1/CYBB/ACSL4/ACSL1	1.22372031770486
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/836	195/9376	1.2078027235922	ACTG1/SLC25A6/NFKB1/RAC1/PRKCA/PIK3R1/ACTB/MAP2K2/PLCB1/SYK/CLEC7A/AKT3/ITGB2/FPR3/VWF/FCGR2A/FPR1/CYBB/CASP4/PLCB4/ITGAM	0.917452078599633
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/836	134/9376	1.25544526172963	CALM1/MYL6/PPP1R14A/CACNA1C/PRKCA/PRKG1/MYH9/ADCY1/RAMP2/MAP2K2/PLCB1/GNA11/PPP1R12A/PLCB4/PRKCE	0.93180944881055
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/836	46/9376	1.462866652798	PSMA7/PSMB9/PSME1/PSMD8/PSME4/PSMB10	0.984586391207485
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/836	158/9376	1.20671067773	GADD45A/MYC/YWHAB/CCND2/CDK4/GADD45B/STAG1/TGFB1/CCND1/CHEK1/MDM2/TFDP2/CDKN1A/TFDP1/YWHAQ/ABL1/GSK3B	0.819847249575719
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/836	67/9376	1.3391416125116	LDHA/ENO1/GAPDH/HK1/ALDH9A1/LDHB/ADH5/GPI	0.871619240619031
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/836	67/9376	1.3391416125116	CALM1/ATF4/CACNA1C/PRKCA/ADCY1/MAP2K2/PLCB1/PLCB4	0.871619240619031
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/836	87/9376	1.28911620744652	TPM4/CACNB2/COX4I1/MT-CO3/SLC8A1/CACNA1C/TPM1/TPM2/SLC9A1/ATP1B1	0.847632157699568
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/836	38/9376	1.47569881641904	GFPT2/UAP1/UGP2/HK1/GPI	0.91929897511969
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/836	243/9376	1.15383858073917	DDX5/HNRNPA1/SRSF5/EIF4A3/HNRNPC/HSPA8/FUS/HNRNPA3/HSPA1A/RBMX/SF3B5/HSPA1B/SNRPB/HNRNPM/PCBP1/SRSF7/TRA2A/SRSF3/SNRPD2/SRSF6/SF3B1/SF1/LSM7/SRSF10/SNRPE	0.76018888292649
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/836	48/9376	1.40191387559809	PIK3R1/PLCB1/HK1/AKT3/ATP1B1/PLCB4	0.873412074435245
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/836	254/9376	1.14802396111969	CALM1/SLC25A6/PDGFRB/SLC8A1/FGF10/EGFR/CACNA1C/PRKCA/ADCY1/FGF7/PLCB1/ATP2B1/BDKRB2/BDKRB1/GNA11/CAMK1D/CYSLTR1/CD38/STIM2/ERBB2/GNA14/NFATC4/PTK2B/PLCB4/PTAFR/VEGFA	0.748279224842397
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/836	160/9376	1.19162679425837	VCAN/ITGB1/ITGAV/PTPRM/NLGN1/ICAM1/NRXN2/HLA-DOB/SDC3/ITGB2/PTPRF/HLA-DQB2/CD276/NTNG2/NLGN4X/JAM2/ITGAM	0.764900305136493
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/836	99/9376	1.2461456671983	CALM1/IL1R1/PRKCA/PIK3R1/ADCY1/PLCB1/IGF1/BDKRB2/BDKRB1/PLCB4/PRKCE	0.770310567987218
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/836	99/9376	1.2461456671983	FOS/JUN/PDGFRB/RAC1/EGFR/PRKCA/PIK3R1/MAP2K2/DGKI/AKT3/DGKD	0.770310567987218
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/836	30/9376	1.49537480063796	NFKB1/FOLR2/IL6/TNF	0.850239918601083
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/836	50/9376	1.34583732057416	CXCL12/IL15/TGFB1/HLA-DOB/HLA-DQB2/IL6	0.767130051252746
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/836	388/9376	1.09840674789128	CALM1/SLC25A6/LRP1/TUBB4B/NFKB1/PSMA7/COX4I1/TUBB3/MT-CO3/ATF4/ERN1/TUBA1C/CACNA1C/NDUFS5/PIK3R1/XBP1/GAPDH/MT-ND1/APP/MAP2K2/PLCB1/AMBRA1/TUBB2A/NRBF2/TUBB/PSMD8/AKT3/CSNK1A1/CAPN2/IL6/TNFRSF1A/CYBB/WNT2/PLCB4/GSK3B/FZD10/TNF/WIPI1	0.619396935233837
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/836	31/9376	1.44713690384319	PRPS2/TKT/PGLS/GPI	0.780174139995109
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/836	72/9376	1.2461456671983	NFKBIA/NFKB1/CXCL8/DDX3X/TBK1/TRIM25/TNF/NFKBIB	0.655969179090414
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/836	32/9376	1.40191387559809	LDHA/LDHB/BCKDHB/SUCLG1	0.712527147589429
Human Diseases	Immune disease	hsa05310	Asthma	4/836	32/9376	1.40191387559809	HLA-DOB/HLA-DQB2/PRG2/TNF	0.712527147589429
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/836	83/9376	1.21611806075979	AUTS2/RYBP/JARID2/PCGF5/ASXL2/L3MBTL4/ASXL1/TFDP1/KDM2A	0.618745396989672
NA	NA	hsa04519	Cadherin signaling	39/836	404/9376	1.08266616135298	ACTG1/NFKBIA/ARPC2/VIM/NFKB1/PRICKLE2/YWHAB/VCL/PDGFRB/TCF7/RAC1/EGFR/PCDH18/GABRA2/SAV1/ACTN4/LHFPL3/ACTB/VASP/MYO1E/MAP2K2/CTNND2/ENAH/PRICKLE1/NCKAP1L/TAOK3/STK3/CSNK1A1/VAV1/TCF7L2/ERBB2/PTK2B/YWHAQ/WNT2/IGF1R/AMOTL1/GSK3B/FZD10/TCF7L1	0.531414821599811
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/836	168/9376	1.13488266119845	HSP90AA1/SLC25A6/HSP90AB1/TNFAIP3/PPIA/IFNGR2/CHMP4B/CFLAR/RBCK1/STAT3/CAPN2/BCL2/TNFRSF1A/STAT2/CYBB/TNFRSF10A/TNF	0.551935022921101
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/836	43/9376	1.30410593078892	ALDH9A1/ECI2/ADH5/ACSL4/ACSL1	0.625328649596721
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/836	23/9376	1.462866652798	ENPEP/ACE2/ACE	0.695351163378226
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/836	117/9376	1.15028830818305	ACTG1/CDK2AP1/EPC1/ARID1B/ACTB/DPF3/CHD4/ZNHIT1/SMARCA2/CHD3/RUVBL1/SMARCA1	0.511794867125205
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/836	75/9376	1.19629984051037	CGA/ATF4/PRKCA/ADCY1/PLCB1/CREB5/ATP1B1/PLCB4	0.534005337388785
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/836	128/9376	1.13905502392344	NME2/PDE8B/IMPDH2/PAPSS2/PRPS2/GUK1/PDE10A/ITPA/ADCY1/PDE7A/APRT/PDE3A/PAICS	0.49559578032295
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/836	107/9376	1.15297589768815	LDHA/CALM1/FOXO1/ATF4/PLCB1/SIK2/CREB5/AKT3/LDHB/PRMT1/PLCB4	0.497918542513832
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/836	86/9376	1.17369533771003	ATF4/CACNA1C/PRKCA/ADCY1/PLCB1/CREB5/GNA11/ATP1B1/PLCB4	0.506278368114411
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/836	65/9376	1.2078027235922	DGKI/PLPP4/ALDH9A1/LIPG/GK/DGKD/AGPAT3	0.525980437482966
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/836	34/9376	1.31944835350408	RORA/CRY1/NFIL3/PER2	0.583821416981413
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/836	226/9376	1.09175593851886	FOS/JUN/CALM1/NFKBIA/NFKB1/CGA/PDE10A/RAC1/CACNA1C/PIK3R1/ADCY1/MAP2K2/ATP2B1/GNAI3/CREB5/SLC9A1/GRIA3/AKT3/PPP1R12A/VAV1/PDE3A/ATP1B1	0.436855387341224
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	35/836	368/9376	1.06667360099854	ACTG1/HNRNPA1/MAP1LC3B/TUBB4B/PSMA7/COX4I1/TUBB3/MT-CO3/FUS/ATF4/ERN1/TUBA1C/HNRNPA3/RAC1/OPTN/NDUFS5/XBP1/VCP/ACTB/MT-ND1/NUP153/SRSF7/SRSF3/AMBRA1/TUBB2A/NRBF2/TBK1/TUBB/PSMD8/BCL2/ACTR1B/TNFRSF1A/NUP160/TNF/WIPI1	0.40824744357239
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/836	35/9376	1.28174982911825	HK1/GMDS/SORD/PFKFB3	0.522469375060609
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/836	89/9376	1.13413257351755	GNG4/CACNA1C/GABRA2/PRKCA/ADCY1/GLS/GNG2/GNAI3/GNAO1	0.397787726706558
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/836	36/9376	1.2461456671983	UGP2/HK1/GBE1/GPI	0.462945481194994
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	29/836	308/9376	1.05598707512583	SOD2/SLC25A6/TGM2/TUBB4B/PSMA7/COX4I1/TUBB3/MT-CO3/ERN1/TUBA1C/IFT57/NDUFS5/MT-ND1/TAF4B/PLCB1/AMBRA1/CREB5/TUBB2A/NRBF2/GRIA3/TUBB/PSMD8/CLTA/AP2M1/ACTR1B/POLR2J3/PLCB4/HTT/WIPI1	0.312584345080173
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/836	47/9376	1.19311819199837	LDHA/ALDH9A1/ME3/LDHB/ADH5	0.415254560588634
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/836	69/9376	1.13778517439845	CALM1/CACNA1C/PLCB1/GNAI3/PDE3A/ACE/PLCB4	0.359403266744684
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/836	102/9376	1.09954029458673	RAB27B/RAC1/PRKCA/ADCY1/PLCB1/ATP2B1/SLC9A1/CD38/ATP1B1/PLCB4	0.316246190982083
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/836	59/9376	1.14054010218149	CGA/PIK3R1/PRKG1/ADCY1/GNAI3/AKT3	0.338803637663397
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/836	27/9376	1.2461456671983	ELOVL5/FADS2/SCD5	0.400729522801124
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/836	38/9376	1.18055905313523	PRKCA/PIK3R1/IGF1/ATP1B1	0.348934550111603
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/836	115/9376	1.07276887871854	DUSP1/GNG4/CACNA1C/PRKCA/APP/PLCB1/GNG2/GNAI3/GNAO1/PLCB4/SLC18A2	0.245654940372065
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/836	17/9376	1.31944835350408	TXNRD1/PAPSS2	0.412448978812061
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/836	138/9376	1.05651480479856	RPS6/CALM1/SOCS3/RHOQ/FOXO1/CBLB/SOCS2/PIK3R1/MAP2K2/HK1/AKT3/PTPRF/GSK3B	0.209253455153021
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/836	116/9376	1.06352087114338	GNG4/CACNA1C/PRKCA/ADCY1/GLS/PLCB1/GNG2/GNAI3/GRIA3/GNAO1/PLCB4	0.215377230601743
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/836	83/9376	1.08099383178648	SOD2/PRDX5/ECI2/PRDX1/GSTK1/ACSL4/NUDT19/ACSL1	0.23188511143518
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/836	83/9376	1.08099383178648	NFKBIA/NFKB1/IFI16/POLR1D/PCBP1/TBK1/IL6/NFKBIB	0.23188511143518
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/836	194/9376	1.04059586642332	ACTG1/TPM4/MYL6/TUBB4B/TUBB3/TUBA1C/MYO16/MYH9/TPM1/ACTB/MYO1E/TUBB2A/TPM2/TUBB/DYNC2LI1/ACTR1B/MYO9A/KIF1B	0.178761453471863
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/836	29/9376	1.16020458670186	RASSF4/SAV1/STK3	0.270332129230033
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/836	18/9376	1.2461456671983	ACSL4/ACSL1	0.327036908831681
NA	NA	hsa04081	Hormone signaling	20/836	219/9376	1.02422931550545	GNG4/ITGAV/CGA/CSH1/ADRA2C/PIK3R1/PRKG1/ADCY1/RAMP2/PLCB1/IGF1/GNG2/GNAI3/STAT3/GNA11/GNAO1/DIO2/GNA14/IGF1R/PLCB4	0.113513218361586
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/836	52/9376	1.0783952889216	CYP1B1/CGA/ADCY1/IGF1/IGF1R	0.177357821631814
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/836	52/9376	1.0783952889216	LRP1/MYLIP/OSBPL5/ABCA1/LIPG	0.177357821631814
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/836	122/9376	1.01121656600518	EEF2/FOXO1/PIK3R1/IGF1/CREB5/CCND1/AKT3/RAB10/SCD5/IGF1R/PFKFB3	0.0390152977534215
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/836	32/9376	1.05143540669856	UGP2/HK1/B4GALT1	0.0911865099593616
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/836	32/9376	1.05143540669856	BCL2/TNFRSF1A/BOK	0.0911865099593616
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/836	44/9376	1.0195737277077	MGAT4C/MGAT2/ALG11/B4GALT1	0.0407166798553042
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/836	44/9376	1.0195737277077	HSPD1/HLA-DOB/HLA-DQB2/TNF	0.0407166798553042
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/836	68/9376	0.989586265128061	ALDH1A3/AOX1/CYP27C1/RDH12/ADH5/RDH10	-0.0269645158683576
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/836	149/9376	0.97851706753155	GNG4/CACNA1C/NDUFS5/GABRA2/PRKCA/ADCY1/MT-ND1/PLCB1/GNG2/GNAI3/GRIA3/GNAO1/PLCB4	-0.0827020507310614
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/836	298/9376	0.97851706753155	CXCL8/CXCL12/IFNGR2/CSH1/IL1R1/CXCL2/IL32/IL15/CSF1R/BMP8B/ACVRL1/TGFB1/BMP2/CXCL1/TGFBR2/IL2RG/IL10RA/IL6/GDF7/TNFRSF1A/CX3CR1/EDA/TSLP/TNFRSF10A/TNFRSF14/TNF	-0.117914291993431
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/836	45/9376	0.996916533758639	HLA-DOB/HLA-DQB2/IL6/TNF	-0.0064869597277979
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/836	57/9376	0.983799210946025	ELOVL5/FADS2/SCD5/ACSL4/ACSL1	-0.0383838718584972
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/836	116/9376	0.966837155584887	PRPS2/ENO1/TKT/PGLS/GAPDH/HK1/ME3/ADH5/SUCLG1/GPI	-0.112443697015455
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/836	10/9376	1.12153110047847	PAPSS2	0.120301265352949
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	23/836	268/9376	0.962508033992716	RPS27A/CALM1/SLC25A6/UBC/DUSP1/TUBB4B/PSMA7/COX4I1/TUBB3/MT-CO3/UBA52/ATF4/ERN1/TUBA1C/NDUFS5/XBP1/MT-ND1/GNAI3/TUBB2A/TUBB/PSMD8/KEAP1/SLC18A2	-0.194829152879862
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/836	23/9376	0.975244435198669	RFC1/SSBP1	-0.037189567839105
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/836	23/9376	0.975244435198669	GLS/ATP1B1	-0.037189567839105
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/836	48/9376	0.934609250398724	BCAT1/AOX1/ALDH9A1/BCKDHB	-0.142102758142242
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/836	36/9376	0.934609250398724	UGP2/KL/SORD	-0.122985516602558
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/836	73/9376	0.921806383954906	PPIA/CHMP4B/NUP153/RAN/MLLT3/AFF4	-0.209836511998947
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/836	24/9376	0.934609250398724	EXT1/XYLT1	-0.100352808030934
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/836	110/9376	0.917616354936929	HSP90AA1/HSP90AB1/PIK3R1/ADCY1/IGF1/GNAI3/AKT3/IGF1R/STK10	-0.271926191161718
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/836	62/9376	0.904460564901991	TLE4/DTX4/CTBP2/DLL1/HES1	-0.23614036957345
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/836	38/9376	0.885419289851423	AOX1/NNMT/CD38	-0.221429874896484
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/836	51/9376	0.879632235669387	ACTG1/PRKCA/KDELR2/ACTB	-0.269668800599963
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/836	39/9376	0.862716231137284	HLA-DOB/HLA-DQB2/TNF	-0.268786628055116
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/836	54/9376	0.830763778132199	REV3L/HES1/FANCL/BRCA1	-0.39020739306881
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/836	14/9376	0.801093643198906	B4GALT1	-0.233017320469418
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/836	42/9376	0.801093643198906	CYP1B1/AOX1/ALDH9A1	-0.404202738311139
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/836	56/9376	0.801093643198906	MGAT4C/MGAT2/ALG11/B4GALT1	-0.467083538622739
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/836	82/9376	0.820632512545221	NME2/TYMP/IMPDH2/MGST3/ITPA/GSTM5	-0.510398228507289
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/836	15/9376	0.747687400318979	TPK1	-0.305973128310738
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/836	108/9376	0.830763778132199	EEF1A1/EIF4A3/KPNA2/NUP153/KPNB1/RAN/NUP160/TNPO1	-0.55344189036676
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/836	30/9376	0.747687400318979	ACLY/SUCLG1	-0.433058451779431
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/836	44/9376	0.764680295780774	STX4/CREB5/DYNC2LI1	-0.489504973371547
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/836	31/9376	0.723568451921593	ALDH9A1/KL	-0.482323743435015
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/836	31/9376	0.723568451921593	ALDH9A1/CNDP2	-0.482323743435015
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/836	45/9376	0.747687400318979	ABCA1/ABCB1/ABCG1	-0.530812256347054
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/836	85/9376	0.791669012102449	NME2/TYMP/IMPDH2/GUK1/ITPA/APRT	-0.603659372119074
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/836	59/9376	0.760360068120996	MGST3/GSTK1/LAP3/GSTM5	-0.577706145005965
NA	NA	hsa04082	Neuroactive ligand signaling	15/836	199/9376	0.84537520136568	GNG4/ADRA2C/GABRA2/PRKCA/P2RY1/ADCY1/PLCB1/GNG2/GNAI3/GRIA3/GNA11/GNAO1/P2RY13/PLCB4/SLC18A2	-0.689787247404544
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/836	73/9376	0.768171986629088	AOX1/MGST3/GSTK1/ADH5/GSTM5	-0.622122165079862
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/836	32/9376	0.700956937799043	IGBP1/WIPI1	-0.530154127670706
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/836	17/9376	0.659724176752041	HSD3B7	-0.439339925448266
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/836	17/9376	0.659724176752041	CA5B	-0.439339925448266
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/836	17/9376	0.659724176752041	MYH9	-0.439339925448266
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/836	61/9376	0.735430229821947	SLC8A1/MT2A/ATP2B1/ATP1B1	-0.64859493002492
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/836	33/9376	0.679715818471799	BCAT1/BCKDHB	-0.576645791742518
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/836	33/9376	0.679715818471799	VAMP5/STX4	-0.576645791742518
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/836	75/9376	0.747687400318979	BCAT1/PRPS2/ENO1/TKT/GAPDH	-0.686379951047333
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/836	18/9376	0.623072833599149	PRDX1	-0.500797339873999
NA	NA	hsa03272	Virion - Hepatitis viruses	3/836	48/9376	0.700956937799043	EGFR/CHMP4B/HSPG2	-0.649860174430986
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/836	34/9376	0.659724176752041	POLR1D/POLR2J3	-0.621885544608394
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/836	103/9376	0.762205602266921	PABPC1/EIF4A3/FUS/PABPC4/ETF1/SMG6/PCF11	-0.759224025442259
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/836	49/9376	0.686651694170491	GALNT13/GXYLT2/B4GALT1	-0.688040882412276
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/836	63/9376	0.712083238399028	PTGDS/PTGES3/TBXAS1/LTC4S	-0.717384953804205
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/836	19/9376	0.590279526567615	HPSE2	-0.559314390279467
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/836	19/9376	0.590279526567615	BCKDHB	-0.559314390279467
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/836	143/9376	0.784287482852076	C1S/C2/C1R/ACTN4/SNRPB/C1QC/HLA-DOB/HLA-DQB2/FCGR2A/TNF	-0.813264451197502
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/836	50/9376	0.672918660287081	ALDH9A1/CNDP2/LAP3	-0.725525875811258
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/836	36/9376	0.623072833599149	GALNT13/ST6GALNAC4	-0.708916514400109
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/836	36/9376	0.623072833599149	RFC1/SSBP1	-0.708916514400109
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/836	79/9376	0.709829810429411	CYP1B1/MGST3/GSTK1/ADH5/GSTM5	-0.810316654706788
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/836	235/9376	0.811320370558892	RPS6/ACTG1/COX4I1/MT-CO3/NDUFS5/ARID1B/PRKG1/ADCY1/ACTB/MT-ND1/DPF3/CREB5/BMP8B/SMARCA2/ACSL4/COX10/ACSL1	-0.916477765059206
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/836	37/9376	0.606233027285659	GFPT2/GLS	-0.75084415219905
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/836	37/9376	0.606233027285659	AOX1/ADH5	-0.75084415219905
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/836	21/9376	0.534062428799271	BCAT1	-0.668767753968945
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/836	38/9376	0.590279526567615	CD3E/IL2RG	-0.791794299904571
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/836	54/9376	0.623072833599149	LDHA/BCAT1/LDHB	-0.869079712101947
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/836	54/9376	0.623072833599149	CGA/HLA-DOB/HLA-DQB2	-0.869079712101947
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/836	70/9376	0.640874914559125	CYP1B1/MGST3/GSTK1/GSTM5	-0.943567730443961
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/836	23/9376	0.487622217599334	GLS	-0.769730299056436
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/836	23/9376	0.487622217599334	B4GALT1	-0.769730299056436
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/836	41/9376	0.547088341696814	SSBP1/BRCA1	-0.909301921248041
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/836	41/9376	0.547088341696814	GABRA2/GRIA3	-0.909301921248041
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/836	86/9376	0.652052965394459	CACNA1C/GABRA2/P2RY1/PLCB1/PLCB4	-1.01417838378845
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/836	43/9376	0.521642372315567	SLC27A4/ABCA1	-0.983639906555544
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/836	26/9376	0.431358115568642	FADS2	-0.908405082599385
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/836	26/9376	0.431358115568642	HES1	-0.908405082599385
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/836	28/9376	0.400546821599453	ELOVL5	-0.993881879568045
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/836	28/9376	0.400546821599453	B4GALT1	-0.993881879568045
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/836	63/9376	0.534062428799271	PRDM6/ALDH9A1/PHYKPL	-1.16094874481372
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/836	29/9376	0.386734862233955	CALM1	-1.03483473156337
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/836	30/9376	0.37384370015949	PIGA	-1.07470763696969
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/836	31/9376	0.361784225960796	SEC11A	-1.11357268515008
NA	NA	hsa04981	Folate transport and metabolism	1/836	31/9376	0.361784225960796	FOLR2	-1.11357268515008
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/836	90/9376	0.498458266879319	ADCY1/SLC9A1/ABCB1/ATP1B1	-1.49580104738832
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/836	138/9376	0.568892587199223	CALM1/YWHAB/ADCY1/IGF1/AR/YWHAQ/IGF1R	-1.59623157139427
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/836	59/9376	0.380180034060498	NME2/TYMP	-1.49421592767533
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/836	39/9376	0.287572077045761	MTHFD1L	-1.39485607606439
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/836	79/9376	0.425897886257646	CLTA/AP2M1/SLC18A2	-1.60321260070249
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/836	63/9376	0.356041619199514	RFC1/POLR2J3	-1.60451253582323
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/836	250/9376	0.628057416267943	NCOA7/LITAF/RAB7A/LAPTM5/OSBPL5/CLTA/AP1S2/AP2M1/GGA2/LGMN/AP3B1/AP3S1/ARSG/RRAGA	-1.86494280549407
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/836	44/9376	0.254893431926925	RFC1	-1.54994827982525
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/836	66/9376	0.3398579092359	CYP1B1/SRD5A1	-1.68381507416923
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/836	104/9376	0.431358115568642	DGKI/PLPP4/DGKD/AGPAT3	-1.82443604991879
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/836	46/9376	0.243811108799667	COX10	-1.60852653125358
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/836	154/9376	0.50978686385385	NME2/BCAT1/UGP2/RDH12/MTHFD1L/COX10/TPK1	-1.91907782786067
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/836	191/9376	0.528470152057917	CALM1/FOSB/GNG4/ATF4/GNG2/GNAI3/CREB5/GNAO1/SLC18A2	-2.05989998176556
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/836	55/9376	0.20391474554154	CERS2	-1.85254818171738
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/836	138/9376	0.406351847999445	COX4I1/MT-CO3/NDUFS5/MT-ND1/COX10	-2.1980599135767
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/836	370/9376	0.545609724557093	GZMA/S1PR3/CGA/CSH1/ADRA2C/GABRA2/P2RY1/BDKRB2/S1PR2/BDKRB1/GRIA3/C3AR1/CYSLTR1/FPR3/FPR1/P2RY13/UTS2/PTAFR	-2.79012564335715
NA	NA	hsa04382	Cornified envelope formation	6/836	217/9376	0.310100765109254	SLC27A4/S100A16/COL4A1/COL4A2/S100A4/PCSK6	-3.21700208441332
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/836	183/9376	0.183857557455487	FBL/RAN/NOB1	-3.48837142097484
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/836	449/9376	0.0999136837842734	CALM1/SLC8A1/PRKG1/ARRB1	-6.11525264254506