category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	41/366	238/9376	4.41309638609542	CFD/RPL3/RPL10/RPLP0/RPL6/RPL7A/RPL18A/RPS18/C1S/RPL10A/RPS4X/RPS2/RPL5/RPS5/PRKCB/RPS9/TAB2/RPS7/PIK3R3/RPL12/RPL13A/C1R/IL6R/RPL29/RPS26/NRP1/CXCL8/RPS29/PRKCG/RPL7/PRKCA/RPS17/RPSA/C9/RPL15/RPL18/RPL37A/RPL8/JAK1/CYBB/TYK2	10.7491776394375
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/366	155/9376	3.96657852987837	ACTG1/FCGR3B/DYNC1H1/CD36/ATP6V1H/RAB7B/TUBB4B/TUBB3/CD14/ITGB1/C1R/CTSS/TUBA1B/TUBA1C/ITGA5/TUBA1A/HLA-DRB5/MARCO/SEC61B/CD209/HLA-G/THBS2/COLEC12/CYBB	7.50579109512642
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/366	203/9376	3.40725187757409	ACTG1/COL6A1/COL1A2/COL6A2/PDPK1/COL1A1/PRKCB/COL6A3/FN1/PIK3R3/PAK3/ITGB1/LAMB1/LAMA2/VASP/ITGA5/PDGFA/PRKCG/PRKCA/EMP1/TNXB/PDGFRB/FLT1/THBS2/ACTN1/SHC3/CRK	6.98839817652439
Genetic Information Processing	Translation	hsa03010	Ribosome	27/366	222/9376	3.11564023039433	RPL3/RPL10/RPLP0/RPL6/RPL7A/RPL18A/RPS18/RPL10A/RPS4X/RPS2/RPL5/RPS5/RPS9/RACK1/RPS7/RPL12/RPL13A/RPL29/RPS26/RPS29/RPL7/RPS17/RPSA/RPL15/RPL18/RPL37A/RPL8	6.42949163212102
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	34/366	362/9376	2.40606225281526	COL6A1/COL1A2/CSH1/COL6A2/EIF4E/PDPK1/COL1A1/COL6A3/EFNA2/GNB1/FN1/PIK3R3/FGF10/ITGB1/IL6R/LAMB1/LAMA2/FGFR1/ITGA5/PDGFA/PRKCA/GNG4/AREG/TNXB/CSF1R/PDGFRB/FLT1/IL2RA/THBS2/HSP90B1/FOXO3/EREG/JAK1/FGF7	5.49874833043627
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/366	103/9376	3.97941535359966	COL3A1/COL1A2/COL1A1/PRKCB/FN1/PIK3R3/RAB7B/CD14/LAMB1/LAMA2/CXCL8/PRKCG/PRKCA/C9/ACTN1/CXCL1	6.12778217980644
NA	NA	hsa04517	IgSF CAM signaling	29/366	299/9376	2.48463914322788	ACTG1/MYL6/NPHS1/PDPK1/PRKCB/TJP2/KCNQ3/NRP2/PIK3R3/SLAMF1/PAK3/TUBB4B/TUBB3/ITGB1/MYH9/DYNLL1/NRP1/FGFR1/TUBA1B/TUBA1C/ITGA5/PRKCG/TUBA1A/PRKCA/CD28/CD209/APP/BAIAP2/ACTN1	5.25834550651215
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/366	89/9376	4.02971695217044	COL6A1/COL1A2/COL6A2/CD44/COL1A1/COL6A3/CD36/FN1/ITGB1/LAMB1/LAMA2/ITGA5/TNXB/THBS2	5.78792803859162
NA	NA	hsa04518	Integrin signaling	18/366	154/9376	2.99425164998935	ACTG1/COL6A1/COL1A2/COL6A2/COL1A1/COL6A3/FN1/PIK3R3/ITGB1/LAMB1/LAMA2/ITGA5/PDGFA/TNXB/PDGFRB/FLT1/THBS2/ACTN1	5.02911477131
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/366	89/9376	3.74188002701541	PRKCB/TUBB4B/TUBB3/TUBA1B/TUBA1C/PDGFA/PRKCG/TUBA1A/ADCY3/PRKCA/PDGFRB/PRKG1/ITPR2	5.23804848352186
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	23/366	233/9376	2.52876474588991	ACTG1/FBLN1/COL6A1/VCAN/COL3A1/VIM/COL1A2/COL6A2/COL1A1/COL6A3/FN1/TPM2/ITGB1/MYH9/ENO2/LAMA2/ITGA5/CAPZB/NID1/THBS2/ACTN2/MYOZ3/AMPD3	4.76253351743267
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/366	205/9376	2.62423030787685	MT-CO3/COL3A1/MT-CO1/COL1A2/MT-ND1/MT-CYB/COL1A1/PRKCB/CD36/GAPDH/PIK3R3/MT-ATP8/MT-ND2/CAMK2A/MT-ND4L/PRKCG/PRKCA/SLC25A6/GFPT2/MT-ND5/CYBB	4.73892656977738
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/366	212/9376	2.53758119393752	ACTG1/MAP2K3/PRKCB/EFNA2/PIK3R3/FGF10/ITGB1/FGFR1/VASP/PDGFA/PRKCG/ADCY3/PRKCA/RASGRP3/CSF1R/PDGFRB/FLT1/CALM1/ADORA2B/FGF7/CRK	4.56380662165492
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/366	110/9376	3.26040735221063	EIF4E/LDHA/PRKCB/TIMP1/GAPDH/PIK3R3/CAMK2A/ENO2/IL6R/PRKCG/PRKCA/FLT1/ELOC/CYBB	4.80618729729297
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	36/366	480/9376	1.92131147540984	MT-CO3/MAP1LC3B/MT-CO1/MT-ND1/MT-CYB/MAP2K3/PRKCB/EIF2AK3/CSNK1A1/MT-ATP8/MT-ND2/TUBB4B/TUBB3/CAMK2A/VCP/MT-ND4L/RB1CC1/TUBA1B/FUS/TUBA1C/PRKCG/TUBA1A/PRKCA/SLC25A6/SLC6A3/PSMD12/UBE2J1/BID/MT-ND5/DNAH2/APP/CALM1/DNAH12/ITPR2/HSPA5/CYBB	4.17631739921378
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/366	100/9376	3.33027322404372	CXCL12/IL6R/CCR7/CCL4L2/CXCL9/IL34/CXCL8/CSF1R/IL2RA/CCR5/TNFRSF10D/CXCL1/CCL3L1	4.72161161354233
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/366	51/9376	4.52073288331726	ACTG1/SLC12A2/TJP2/ATP6V1H/ADCY3/PRKCA/KCNQ1/SEC61B/ARF1	5.08109751416396
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/366	103/9376	3.23327497479972	COL6A1/COL3A1/COL1A2/COL6A2/COL1A1/COL15A1/COL6A3/SLC8A2/SLC3A2/CELA2A/KCNQ1/CELA2B/SLC38A2	4.59319059917292
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/366	80/9376	3.5224043715847	EIF4E/PRKCB/PIK3R3/IL6R/PDGFA/PRKCG/PRKCA/PDGFRB/FOXO3/JAK1/SHC3	4.56641556534059
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/366	248/9376	2.27251894940948	ACTG1/TCF7L2/TXN/MAP2K3/SNX9/DYNC1H1/TAB2/GAPDH/PAK3/RAB7B/ANXA2/TUBB4B/TUBB3/CD14/DYNLL1/TUBA1B/CXCL8/TUBA1C/TUBA1A/TCF7/ARF1/HSP90B1	4.09322924484153
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	20/366	216/9376	2.37198947581461	ABCA1/PDPK1/MAP2K3/EIF2AK3/CD36/TAB2/PIK3R3/CAMK2A/CD14/ABCG1/CXCL8/PRKCA/NFATC1/BID/HSP90B1/CALM1/HSPA5/CYBB/CXCL1/CCL3L1	4.1114376083918
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	23/366	268/9376	2.19851561862817	MT-CO3/MT-CO1/MT-ND1/MT-CYB/TXN/EIF2AK3/MT-ATP8/MT-ND2/TUBB4B/TUBB3/CAMK2A/MT-ND4L/TUBA1B/TUBA1C/TUBA1A/SLC25A6/SLC6A3/PSMD12/UBE2J1/MT-ND5/CALM1/ITPR2/HSPA5	4.01202258763703
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	28/366	368/9376	1.94915656925636	ACTG1/MT-CO3/MAP1LC3B/MT-CO1/MT-ND1/MT-CYB/MAP2K3/EIF2AK3/MT-ATP8/MT-ND2/TUBB4B/TUBB3/NXF1/VCP/MT-ND4L/RB1CC1/TUBA1B/FUS/TUBA1C/NUP210L/TUBA1A/PSMD12/BID/MT-ND5/DNAH2/HNRNPA1/DNAH12/HSPA5	3.74378899982666
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/366	227/9376	2.25704725451963	PRKCB/CXCL12/GNB1/PIK3R3/IL6R/CCL4L2/CXCL8/PRKCG/ADCY3/PRKCA/NFATC1/GNG4/HLA-G/BID/JAK1/CALM1/CCR5/ITPR2/CRK/CCL3L1	3.86403902607677
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	19/366	214/9376	2.27444972166896	MAP2K3/PRKCB/GNB1/TAB2/PIK3R3/PAK3/AP1G1/PRKCG/PRKCA/NFATC1/GNG4/HLA-G/BID/CHEK1/CALM1/ELOC/CCR5/ITPR2/CRK	3.80100319930172
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/366	76/9376	3.37072188668392	ACTG1/PRKCB/CAMK2A/SLC9A1/PRKCG/ADCY3/PRKCA/KCNQ1/CALM1/ITPR2	4.18224736713812
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/366	76/9376	3.37072188668392	GADD45A/PRKCB/PIK3R3/CAMK2A/PDGFA/PRKCG/PRKCA/PDGFRB/CALM1/SHC3	4.18224736713812
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	18/366	204/9376	2.26036644165863	ACTG1/COL1A2/CD44/PDPK1/COL1A1/DDX5/PRKCB/FN1/PIK3R3/CAMK2A/ITGB1/FGFR1/SLC9A1/ITGA5/PRKCG/PRKCA/TWIST2/ITPR2	3.66812120281854
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/366	300/9376	1.9640072859745	GADD45A/MAP2K3/PRKCB/EFNA2/TAB2/CACNG7/FGF10/CD14/FGFR1/PDGFA/PRKCG/MAPKAPK2/PRKCA/NFATC1/AREG/RASGRP3/CACNB2/CSF1R/PDGFRB/FLT1/EREG/FGF7/CRK	3.42024711687967
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/366	196/9376	2.22192483550797	MAP1LC3B/TCF7L2/GNB1/PIK3R3/CXCL8/MAPKAPK2/TCF7/NFATC1/GNG4/HLA-G/BID/JAK1/CALM1/CCR5/ITPR2/CXCL1/TYK2	3.48429543861883
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/366	86/9376	2.97877748125556	PRKCB/PIK3R3/PAK3/CAMK2A/PRKCG/PRKCA/AREG/EREG/SHC3/CRK	3.71537037118855
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/366	86/9376	2.97877748125556	ACTG1/TCF7L2/SLC8A2/CACNG7/ITGB1/LAMA2/ITGA5/TCF7/CACNB2/ACTN2	3.71537037118855
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/366	101/9376	2.79002326462154	COL3A1/COL1A2/COL1A1/PRKCB/FN1/PIK3R3/CXCL8/PRKCA/NFATC1/THBD/CYBB	3.64524051525713
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/366	102/9376	2.76267009536055	SLC12A2/PRKCB/SLC9A1/PRKCG/ADCY3/PRKCA/CELA2A/KCNQ1/RAB27B/CELA2B/ITPR2	3.6074586524176
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	19/366	238/9376	2.04509344721495	PRKCB/EFNA2/GNB1/PIK3R3/PAK3/FGF10/FGFR1/PDGFA/PRKCG/PRKCA/GNG4/RASGRP3/CSF1R/PDGFRB/FLT1/ETS2/CALM1/SHC3/FGF7	3.29140869261449
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/366	75/9376	3.07409836065574	CGA/PRKCB/SLC5A5/PRKCG/ADCY3/PRKCA/HSP90B1/ITPR2/HSPA5	3.63461942358994
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/366	275/9376	1.95624441132638	MT-CO3/MT-CO1/MT-ND1/MT-CYB/EIF2AK3/PIK3R3/MT-ATP8/MT-ND2/TUBB4B/TUBB3/MT-ND4L/TUBA1B/TUBA1C/TUBA1A/SLC25A6/C9/PSMD12/MT-ND5/ITPR2/HSPA5/CYBB	3.24380310454162
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/366	137/9376	2.43085636791512	ACTG1/GADD45A/PDPK1/SEPTIN4/EIF2AK3/PIK3R3/CFLAR/CTSS/TUBA1B/TUBA1C/TUBA1A/BID/ITPR2	3.40022476437722
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/366	93/9376	2.75456842352665	SLC12A2/PRKCB/SLC9A1/LYZ/PRKCG/ADCY3/PRKCA/CALM1/PRKG1/ITPR2	3.42713643144495
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/366	157/9376	2.28436183912847	ABCA1/CD36/LIPA/PPARD/RAB7B/CAMK2A/ADAM9/PBX1/MAPKAPK2/NFATC1/HAVCR2/SLC16A1/SIRPA/CRK	3.27083847311154
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/366	65/9376	3.15292139554435	CGA/PRKCB/PIK3R3/TRPC4/PRKCG/PRKCA/GPER1/ITPR2	3.51035043761101
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/366	193/9376	2.12372943741329	PRKCB/CXCL12/GNB1/PIK3R3/CCR7/CCL4L2/CXCL9/CXCL8/ADCY3/GNG4/FOXO3/CCR5/SHC3/CXCL1/CRK/CCL3L1	3.17915648690267
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/366	194/9376	2.11278237845755	ACTG1/MYL6/DYNC1H1/TPM2/MYO9B/TUBB4B/TUBB3/MYH9/DYNLL1/MYO1E/TUBA1B/TUBA1C/TUBA1A/CAPZB/DNAH2/DNAH12	3.15650328687631
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	15/366	178/9376	2.15877693866274	SFRP2/TCF7L2/PRKCB/CSNK1A1/PPARD/FOSL1/CAMK2A/APCDD1/PRKCG/TLE4/PRKCA/TCF7/NFATC1/NOTUM/SFRP4	3.14576971790448
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/366	232/9376	1.98756359525155	ACTG1/CXCL12/FN1/PIK3R3/PAK3/FGF10/ITGB1/MYH9/FGFR1/SLC9A1/ITGA5/PDGFA/C9/PDGFRB/BAIAP2/ACTN1/FGF7/CRK	3.06976225087611
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	26/366	388/9376	1.71663568249676	MT-CO3/MT-CO1/MT-ND1/RTN4/MT-CYB/EIF2AK3/CSNK1A1/GAPDH/PIK3R3/MT-ATP8/MT-ND2/TUBB4B/TUBB3/MT-ND4L/RB1CC1/TUBA1B/TUBA1C/TUBA1A/SLC25A6/PSMD12/BID/MT-ND5/APP/CALM1/ITPR2/CYBB	2.90567170924605
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/366	200/9376	2.04939890710383	ACTG1/TAB2/GAPDH/PAK3/TUBB4B/TUBB3/ITGB1/MYH9/MYO1E/TUBA1B/CXCL8/TUBA1C/TUBA1A/ARF1/BAIAP2/TMBIM6	3.02337966944804
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/366	115/9376	2.4503682584937	PRKCB/GNB1/KCNQ3/PIK3R3/CAMK2A/PRKCG/ADCY3/PRKCA/GNG4/KCNQ1/ITPR2	3.1540026223522
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/366	56/9376	3.20218579234973	EEF1A1/CD14/VCP/EEF1G/CXCL8/ARF1/CXCL1	3.3312237116103
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/366	154/9376	2.16251508054787	ACTG1/MYL6/PRKCB/EEF2/CACNG7/CAMK2A/PRKCG/ADCY3/PRKCA/NFATC1/CACNB2/CALM1/ITPR2	2.93163691928505
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/366	157/9376	2.12119313633358	GADD45A/MAP2K3/PIK3R3/HIPK4/CXCL8/MAPKAPK2/NFATC1/SLC25A6/HLA-G/FOXO3/CHEK1/CALM1/ITPR2	2.85530255912691
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/366	109/9376	2.35022810447686	MAP2K3/TAB2/PIK3R3/CD14/CCL4L2/CXCL9/CXCL8/JAK1/TYK2/CCL3L1	2.85768658629539
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/366	78/9376	2.62743449628696	FCGR3B/PRKCB/EEF1A1/TAB2/ITGB1/HLA-DRB5/JAK1/CYBB	2.90883999706254
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/366	95/9376	2.42691975841242	CXCL12/ATP6V1H/CXCL8/HLA-DRB5/CD28/IL11/FLT1/CXCL1/CCL3L1	2.817265346784
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/366	112/9376	2.28727556596409	PDPK1/MAP2K3/TAB2/ITGB1/LAMB1/LAMA2/HLA-DRB5/JAK1/CCR5/TYK2	2.7621359441125
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/366	97/9376	2.37688017576475	PRKCB/GNB1/CAMK2A/PRKCG/ADCY3/PRKCA/GNG4/CALM1/PRKG1	2.74723121349772
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/366	149/9376	2.06315326218506	MT-ND1/PRKCB/GNB1/MT-ND2/MT-ND4L/PRKCG/ADCY3/PRKCA/GNG4/MT-ND5/ITPR2/MGLL	2.63646818790451
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/366	99/9376	2.32886239443617	MAP2K3/PRKCB/PIK3R3/CAMK2A/PRKCG/ADCY3/PRKCA/CALM1/ITPR2	2.67890686936457
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/366	116/9376	2.20840399472395	ACTG1/PRKCB/CXCL12/PIK3R3/ITGB1/VASP/PRKCG/PRKCA/ACTN1/CYBB	2.63936491276818
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/366	52/9376	2.95586380832282	ABCA1/CD36/MYLIP/LIPA/PLTP/CETP	2.8503811368674
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/366	38/9376	3.37072188668392	PDPK1/PRKCB/PIK3R3/PRKCG/PRKCA	2.95127213978307
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/366	134/9376	2.10292798303564	MYL6/PRKCB/ADM/MYH9/PRKCG/ADCY3/PRKCA/CALM1/ADORA2B/PRKG1/ITPR2	2.59167391796041
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/366	100/9376	2.3055737704918	CD44/CD36/CD14/IL6R/ITGA5/HLA-DRB5/CSF1R/IL11/IL2RA	2.64536030088062
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/366	69/9376	2.59887542567514	PRKCB/CAMK2A/PRKCG/PRKCA/SLC6A3/ARC/CALM1	2.68656963232108
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/366	308/9376	1.66347313888297	TGM2/MT-CO3/MT-CO1/MT-ND1/MT-CYB/MT-ATP8/MT-ND2/TUBB4B/TUBB3/MT-ND4L/RB1CC1/TUBA1B/TUBA1C/TUBA1A/TAF4B/SLC25A6/PSMD12/MT-ND5/DNAH2/DNAH12	2.38619940351813
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/366	138/9376	2.04197354874475	ACTG1/MAP2K3/FN1/TAB2/PIK3R3/ITGB1/CXCL8/ITGA5/NFATC1/BAIAP2/CRK	2.48525550165164
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/366	87/9376	2.35563092770555	MT-CO3/MT-CO1/MT-CYB/SLC8A2/TPM2/CACNG7/SLC9A1/CACNB2	2.56023835022816
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/366	333/9376	1.61551715650076	COL6A1/COL1A2/COL6A2/TCF7L2/COL1A1/COL6A3/FN1/CSNK1A1/ATP6V1H/PIK3R3/ITGB1/LAMB1/LAMA2/ITGA5/TCF7/TNXB/HLA-G/PDGFRB/THBS2/JAK1/TYK2	2.30499400085671
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/366	122/9376	2.09979396219654	CSH1/MAP2K3/PRKCB/PIK3R3/PRKCG/ADCY3/PRKCA/SHC3/ITPR2/CRK	2.46428131602265
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/366	254/9376	1.71455617228174	PRKCB/SLC8A2/CAMK2A/FGF10/FGFR1/PDGFA/PRKCG/ADCY3/PRKCA/NFATC1/SLC25A6/PDGFRB/FLT1/CALM1/ADORA2B/ITPR2/FGF7	2.32686927346096
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/366	105/9376	2.19578454332553	GADD45A/PRKCB/CXCL12/TAB2/CD14/CFLAR/CCL4L2/CXCL8/CXCL1	2.48340802306436
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/366	105/9376	2.19578454332553	ACTG1/SLC8A2/TPM2/CACNG7/ITGB1/LAMA2/ITGA5/ADCY3/CACNB2	2.48340802306436
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/366	56/9376	2.74473067915691	CSNK1A1/PTCH2/IQCE/SCUBE2/CUL3/BOC	2.6392360848809
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/366	106/9376	2.17506959480359	TCF7L2/PDPK1/PIK3R3/ZEB1/FGFR1/PDGFA/TCF7/PDGFRB/HSP90B1	2.45211277493593
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/366	42/9376	3.04970075461879	MAP1LC3B/ACSL3/SLC3A2/LPCAT3/CYBB	2.68315025328188
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/366	142/9376	1.98445316708997	FCGR3B/TAB2/PIK3R3/FOSL1/NFATC1/CSF1R/SIRPA/LILRB5/JAK1/ITPR2/TYK2	2.38236380889107
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/366	73/9376	2.45647129276143	GADD45A/PIK3R3/FGF10/FGFR1/PDGFA/PDGFRB/FGF7	2.51776756248579
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/366	73/9376	2.45647129276143	GADD45A/PDPK1/PRKCB/PIK3R3/PRKCG/PRKCA/FOXO3	2.51776756248579
Organismal Systems	Immune system	hsa04611	Platelet activation	10/366	126/9376	2.03313383641252	ACTG1/COL3A1/COL1A2/COL1A1/PIK3R3/ITGB1/VASP/ADCY3/PRKG1/ITPR2	2.35306962146226
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/366	17/9376	4.52073288331726	NRP2/MYH9/CD209	2.92823952926008
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/366	59/9376	2.60516810225063	GADD45A/TCF7L2/PDPK1/PIK3R3/TCF7/FOXO3	2.49271291818144
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/366	93/9376	2.20365473882132	CGA/MAP2K3/PRKCB/CAMK2A/ADCY3/PRKCA/CALM1/ITPR2	2.3510562204263
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/366	78/9376	2.29900518425109	ACTG1/FN1/PIK3R3/ITGB1/ITGA5/SHC3/CRK	2.32181279490028
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/366	78/9376	2.29900518425109	C1S/CD14/ITGB1/C1R/CXCL8/ITGA5/CALM1	2.32181279490028
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/366	115/9376	2.00484675694939	PDE4C/PRKCB/NACA/FGFR1/PRKCG/ADCY3/PRKCA/MMP16/ITPR2	2.1851617945445
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/366	98/9376	2.09122337459574	PRKCB/PIK3R3/MTMR14/PRKCG/PRKCA/CALM1/MTMR4/ITPR2	2.18858440053368
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/366	98/9376	2.09122337459574	FCGR3B/PRKCB/PIK3R3/VASP/PRKCG/PRKCA/ASAP1/CRK	2.18858440053368
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/366	116/9376	1.98756359525155	PRKCB/GNB1/PRKCG/ADCY3/PRKCA/GNG4/GRIK5/SLC38A2/ITPR2	2.15701099451396
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/366	99/9376	2.07009990616548	ACTG1/SLC8A2/TPM2/CACNG7/ITGB1/LAMA2/ITGA5/CACNB2	2.15725721604864
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/366	136/9376	1.88363870138219	TAB2/RACK1/PIK3R3/SLAMF1/CD28/CD209/BID/IL2RA/JAK1/TYK2	2.09204962792034
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/366	235/9376	1.63515870247646	ACTG1/MT-CO3/MT-CO1/MT-ND1/MT-CYB/MAP2K3/MT-ATP8/MT-ND2/MT-ND4L/FGFR1/ACSL3/ADCY3/MT-ND5/PRKG1/MGLL	1.98739006718461
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/366	101/9376	2.02910782881567	TCF7L2/PRKCB/CAMK2A/PRKCG/ADCY3/PRKCA/TCF7/CALM1	2.09569653440247
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/366	158/9376	1.78349588434668	EIF4E/PDPK1/PRKCB/ATP6V1H/PIK3R3/SESN2/PRKCG/PRKCA/SLC3A2/FNIP2/MAPKAP1	2.00175396069393
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/366	67/9376	2.2941032542207	PRKCB/CAMK2A/PRKCG/PRKCA/CALM1/ITPR2	2.14248900036455
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/366	68/9376	2.26036644165863	TCF7L2/PPARD/PIK3R3/CD14/TCF7/CSF1R	2.10226222011958
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/366	163/9376	1.72878742163666	MAP2K3/PRKCB/TAB2/PIK3R3/CXCL8/PRKCG/PRKCA/NFATC1/BID/JAK1/TYK2	1.89172463915046
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/366	37/9376	2.76945798257274	PRKCB/PRKCG/PRKCA/HBB	2.17347532503269
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/366	70/9376	2.19578454332553	ACTG1/LAMA2/HLA-DRB5/CD28/HLA-G/BID	2.02387747438129
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/366	88/9376	2.03775459513164	CFD/C1S/C1R/PROCR/SERPINE2/C9/THBD	1.97123627815818
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/366	184/9376	1.67070563079116	PDPK1/CXCL12/EFNA2/PIK3R3/PAK3/CAMK2A/SEMA5A/ITGB1/NRP1/TRPC4/PRKCA/BOC	1.8518237148769
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/366	205/9376	1.62452352392376	VIM/GADD45A/CD44/MAP2K3/TAB2/PIK3R3/HLA-DRB5/PSMD12/HLA-G/BID/USP7/JAK1/TYK2	1.82213760365179
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/366	89/9376	2.01485847608522	PRKCB/GNB1/PRKCG/ADCY3/PRKCA/GNG4/SLC38A2	1.93877115310327
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/366	227/9376	1.57993307816374	MT-CO3/MT-CO1/MT-ND1/MT-CYB/PDPK1/PIK3R3/MT-ATP8/MT-ND2/MT-ND4L/SLC25A6/CYP1B1/MT-ND5/FOXO3/GSTO2	1.78265696733402
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/366	148/9376	1.73091123910796	GADD45A/TCF7L2/DLL3/CSNK1A1/PIK3R3/FGF10/FGFR1/TCF7/SHC3/FGF7	1.80636491843957
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/366	91/9376	1.97057587221522	PDE4C/PRKCB/GNB1/PRKCG/ADCY3/PRKCA/GNG4	1.87509388887496
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/366	130/9376	1.77351828499369	COL3A1/COL1A2/COL1A1/GNB1/PIK3R3/ADCY3/PRKCA/GNG4/SHC3	1.78990137365479
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/366	170/9376	1.65760205721633	ACTG1/MYL6/TJP2/ITGB1/MYH9/TUBA1B/VASP/RAB13/TUBA1C/TUBA1A/ACTN1	1.74387729786108
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/366	170/9376	1.65760205721633	ACTG1/GADD45A/TCF7L2/PRKCB/CSNK1A1/PIK3R3/PRKCG/PRKCA/TCF7/GSTO2/SHC3	1.74387729786108
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/366	253/9376	1.51882330071924	ACTG1/MAP1LC3B/CD44/TAB2/PIK3R3/CD14/ITGB1/CXCL8/ITGA5/ARF1/FOXO3/ACTN1/ITPR2/ATG16L1/CRK	1.68606642735147
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/366	93/9376	1.92819789646865	ACTG1/TCF7L2/RADIL/FGFR1/TCF7/BAIAP2/ACTN1	1.81301611491698
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/366	94/9376	1.9076851528892	MAPK6/TAB2/FOSL1/CXCL8/S100A9/HSP90B1/CXCL1	1.78255181146078
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/366	298/9376	1.46140022738108	CSH1/CXCL12/IL6R/TNFSF15/CCR7/CCL4L2/CXCL9/IL34/CXCL8/CSF1R/IL11/IL2RA/GDF11/CCR5/TNFRSF10D/CXCL1/CCL3L1	1.63137811694393
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/366	76/9376	2.02243313201035	PDPK1/PLIN2/CD36/PPARD/PLTP/ACSL3	1.80369882205217
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/366	133/9376	1.73351411315173	FCGR3B/PRKCB/PIK3R3/PRKCG/PRKCA/NFATC1/HLA-G/BID/SHC3	1.71708424603942
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/366	133/9376	1.73351411315173	PRKCB/GNB1/CAMK2A/PRKCG/PRKCA/GNG4/SLC6A3/CALM1/ITPR2	1.71708424603942
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/366	173/9376	1.62885751287154	ACTG1/PRKCB/PIK3R3/NXF1/CXCL8/PRKCA/HLA-DRB5/SLC25A6/BID/JAK1/TYK2	1.68257479812901
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/366	12/9376	4.2695810564663	SLAMF1/CD209	2.28410368459385
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/366	154/9376	1.66347313888297	SLC8A2/TPM2/CACNG7/CAMK2A/SLC9A1/ADCY3/PRKCA/CACNB2/KCNQ1/CALM1	1.67315020807008
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/366	59/9376	2.17097341854219	CGA/PIK3R3/ADCY3/PRKG1/MGLL	1.8184391797685
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/366	323/9376	1.42759985788966	VIM/CD44/PRKCB/EFNA2/PIK3R3/ZEB1/ITGA5/PDGFA/PRKCG/PRKCA/SLC7A1/TNXB/CYP1B1/MMP16/PDGFRB/SOX4/ST14/CRK	1.57618190939376
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/366	60/9376	2.13479052823315	PRKCB/PIK3R3/PRKCG/MAPKAPK2/PRKCA	1.77721664822297
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/366	60/9376	2.13479052823315	PRKCB/PRKCG/PRKCA/PRKG1/ITPR2	1.77721664822297
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/366	98/9376	1.82982045277127	PRKCB/CAMK2A/PRKCG/ADCY3/PRKCA/CALM1/ITPR2	1.66430828046716
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/366	138/9376	1.67070563079116	MT-CO3/MT-CO1/MT-ND1/MT-CYB/ATP6V1H/MT-ATP8/MT-ND2/MT-ND4L/MT-ND5	1.59972857364808
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/366	99/9376	1.81133741789479	CFD/FCGR3B/C1S/C1R/KRT19/HLA-DRB5/KRT10	1.6356075627327
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/366	99/9376	1.81133741789479	PDPK1/PRKCB/PIK3R3/PDGFA/PRKCG/PRKCA/PDGFRB	1.6356075627327
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/366	139/9376	1.65868616582144	PIK3R3/KRT19/ADCY3/HSP90B1/CALM1/KRT10/GPER1/SHC3/ITPR2	1.57682775575711
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/366	201/9376	1.52940216948047	GADD45A/DDX5/DOT1L/ZEB1/PBX1/CD14/FUS/CXCL8/PDGFA/KDM6A/CSF1R/FLT1	1.52913030118446
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/366	120/9376	1.70783242258652	PDPK1/PIK3R3/CAMK2A/MAPKAPK2/FOXO3/CALM1/SHC3/CRK	1.57279886569093
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/366	29/9376	2.65008479366874	GNB1/SLC24A1/CALM1	1.79363027188171
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/366	122/9376	1.67983516975723	ACTG1/PDPK1/PRKCB/PIK3R3/SLC9A1/PRKCG/PRKCA/MED13	1.52328996556943
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/366	144/9376	1.60109289617486	TCF7L2/MAP2K3/TAB2/CD14/CXCL8/TCF7/ACADVL/FOXO3/CXCL1	1.46500372508195
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/366	144/9376	1.60109289617486	RORA/PRKCB/PIK3R3/RB1CC1/PRKCG/PRKCA/SLC25A6/PSMD12/ITPR2	1.46500372508195
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/366	187/9376	1.50691096110575	MAP1LC3B/ERBIN/TXN/TAB2/CXCL8/JAK1/ITPR2/CYBB/CXCL1/TYK2/ATG16L1	1.4111791303277
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/366	48/9376	2.13479052823315	PRKCB/PIK3R3/SLC2A5/MGAM	1.58856810129364
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/366	168/9376	1.52485037730939	CSH1/PIK3R3/IL6R/PDGFA/IL11/PDGFRB/IL2RA/JAK1/AOX1/TYK2	1.38347490141273
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/366	87/9376	1.76672319577916	GADD45A/TCF7L2/PIK3R3/TCF7/AREG/EREG	1.44802990970834
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/366	169/9376	1.5158275940117	MAP1LC3B/PDPK1/EIF2AK3/PIK3R3/RAB7B/CFLAR/RB1CC1/MTMR14/MTMR4/ATG16L1	1.36380612629678
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/366	50/9376	2.04939890710383	CD36/CXCL8/HBB/THBS2	1.49948349428931
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/366	109/9376	1.6451596731338	RORA/IL6R/NFATC1/HLA-DRB5/IL2RA/JAK1/TYK2	1.36544642925168
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/366	90/9376	1.70783242258652	EIF4E/PIK3R3/RB1CC1/SESN2/ADCY3/FOXO3	1.35988177133586
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/366	90/9376	1.70783242258652	MAP2K3/PIK3R3/NFATC1/CD28/JAK1/CD274	1.35988177133586
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/366	53/9376	1.93339519538097	PRKCB/SLC8A2/PRKCG/PRKCA	1.37337595379485
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/366	93/9376	1.65274105411599	DLL3/NFATC1/HLA-DRB5/IL2RA/JAK1/TYK2	1.27497600940765
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/366	93/9376	1.65274105411599	GADD45A/FN1/PIK3R3/ITGB1/LAMB1/LAMA2	1.27497600940765
NA	NA	hsa04082	Neuroactive ligand signaling	11/366	199/9376	1.41604195842601	PRKCB/GNB1/PRKCG/ADCY3/PRKCA/GNG4/ADRA2B/OGFRL1/SLC6A3/GRIK5/ADORA2B	1.19557572853554
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/366	73/9376	1.75462235197245	SUPT5H/PPIA/NELFB/TNPO3/CCR5	1.30449785667982
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/366	54/9376	1.89759158065169	CGA/HLA-DRB5/CD28/HLA-G	1.33316801702372
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/366	115/9376	1.55932525540508	PRKCB/GNB1/PRKCG/PRKCA/GNG4/APP/ITPR2	1.21632096673681
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/366	180/9376	1.42319368548877	TAB2/PIK3R3/NXF1/EIF2B3/ITGA5/HLA-DRB5/HLA-G/BID/JAK1/TYK2	1.15541961370565
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/366	224/9376	1.37236533957845	PIK3R3/FOSL1/NRP1/ADCY3/NFATC1/HLA-DRB5/SLC25A6/HLA-G/IL2RA/ETS2/JAK1/CHEK1	1.13683919427406
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/366	181/9376	1.41533073695016	FCGR3B/ATP6V1H/CAMK2A/CD14/CTSS/HLA-DRB5/CD209/BID/JAK1/CALM1	1.13715922470961
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/366	37/9376	2.07709348692955	GADD45A/TCF7L2/TCF7	1.32302441744958
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/366	140/9376	1.46385636221702	MAP1LC3B/GNB1/SLC8A2/SLC9A1/ADCY3/GNG4/CALM1/ITPR2	1.11447250581833
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/366	38/9376	2.02243313201035	UAP1/GFPT2/CHIT1	1.27280995474085
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/366	99/9376	1.55257492962411	DLL3/PIK3R3/ADCY3/CARM1/GPER1/SHC3	1.11395790941677
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/366	142/9376	1.44323866697452	ACTG1/TXN/PIK3R3/PDGFA/THBD/HSP90B1/GSTO2/CALM1	1.07263178605298
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/366	39/9376	1.97057587221522	HLA-DRB5/CD28/HLA-G	1.22411409999196
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/366	21/9376	2.43976060369503	CHST7/CHST15	1.33119544407547
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/366	166/9376	1.38889986174205	SLC8A2/VASP/ADCY3/NFATC1/ADRA2B/SLC25A6/CALM1/PRKG1/ITPR2	1.01888648850102
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/366	22/9376	2.32886239443617	CNDP1/CNDP2	1.2576403260339
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/366	125/9376	1.43457923497268	PDPK1/PRKCB/SGMS2/PIK3R3/PRKCG/PRKCA/BID	0.985810461230615
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/366	149/9376	1.37543550812337	PIK3R3/CXCL8/PDGFA/ADCY3/PRKCA/PDGFRB/ARF1/SHC3	0.931026418282054
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/366	105/9376	1.46385636221702	PIK3R3/MAPKAPK2/NFATC1/CD209/CALM1/ITPR2	0.963337934002376
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/366	217/9376	1.29858225680542	DLL3/PRKCB/PIK3R3/FGF10/PRKCG/ADCY3/PRKCA/CYP1B1/HSP90B1/GSTO2/FGF7	0.89687851216747
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/366	63/9376	1.62650706913002	GADD45A/TCF7L2/PTCH2/TCF7	1.00557677520988
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/366	195/9376	1.31371724814348	ACTG1/FCGR3B/PRKCB/PIK3R3/AZU1/AQP9/PRKCG/PRKCA/SLC25A6/CYBB	0.892225218339861
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/366	150/9376	1.36626593806922	GADD45A/TCF7L2/CSNK1A1/PIK3R3/FGF10/TCF7/SHC3/FGF7	0.911379429273604
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/366	24/9376	2.13479052823315	HS3ST2/EXT1	1.12184500707307
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/366	86/9376	1.48938874062778	PRKCB/CAMK2A/PRKCG/ADCY3/PRKCA	0.918880694846003
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/366	44/9376	1.74664679582712	HLA-DRB5/CD28/HLA-G	1.00050200728395
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/366	44/9376	1.74664679582712	DYNC1H1/DYNLL1/ADCY3	1.00050200728395
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/366	109/9376	1.41013686268612	PDPK1/PRKCB/CD36/PIK3R3/OGT/GFPT2	0.868033043570437
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/366	45/9376	1.70783242258652	ABCA1/ABCG1/ABCB4	0.959260141605126
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/366	45/9376	1.70783242258652	HLA-DRB5/CD28/HLA-G	0.959260141605126
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/366	67/9376	1.52940216948047	LDHA/GAPDH/ENO2/TPI1	0.876466635240832
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/366	157/9376	1.30534962235912	MT-CO3/MT-CO1/MT-CYB/EIF2AK3/PIK3R3/IL6R/CXCL8/BID	0.777622989203748
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/366	68/9376	1.50691096110575	ALDH1A3/RDH12/RDH10/AOX1	0.84551581768135
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/366	91/9376	1.40755419443944	PRKCB/PIK3R3/NFATC1/RASGRP3/LILRB5	0.787370056536186
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/366	69/9376	1.48507167181437	PDPK1/MAP2K3/PIK3R3/PRKCA	0.815059636334967
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/366	70/9376	1.46385636221702	PIK3R3/PAK3/ELOC/CRK	0.785081600259409
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/366	71/9376	1.44323866697452	CGA/PIK3R3/FOXO3/SHC3	0.7555660076656
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/366	71/9376	1.44323866697452	LDHA/PIK3R3/FGFR1/PDGFRB	0.7555660076656
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/366	50/9376	1.53704918032787	PRODH2/CNDP1/CNDP2	0.767388241089112
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/366	50/9376	1.53704918032787	CXCL12/HLA-DRB5/CD28	0.767388241089112
NA	NA	hsa04519	Cadherin signaling	18/366	404/9376	1.14137315370881	ACTG1/VIM/TCF7L2/ERBIN/MAP2K3/CSNK1A1/KRT19/FGFR1/MYO1E/VASP/SAV1/TMC4/ATN1/TCF7/PDGFRB/ACTN1/KRT10/LHFPL2	0.585432437058893
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/366	143/9376	1.25400282777332	FCGR3B/C1S/C1R/HLA-DRB5/CD28/C9/ACTN1	0.616877511178061
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/366	52/9376	1.47793190416141	CGA/ADCY3/CYP1B1	0.696514797467921
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/366	168/9376	1.21988030184751	PPIA/CAMK2A/CFLAR/SLC25A6/BID/JAK1/CYBB/TYK2	0.579591617101518
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/366	75/9376	1.36626593806922	PDPK1/PIK3R3/BID/GSTO2	0.641839036160699
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/366	75/9376	1.36626593806922	GADD45A/SESN2/BID/CHEK1	0.641839036160699
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/366	122/9376	1.25987637731793	PDPK1/EEF2/CD36/PIK3R3/RAB2A/FOXO3	0.58229861511621
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/366	31/9376	1.65274105411599	CNDP1/CNDP2	0.733661801612477
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/366	31/9376	1.65274105411599	SEC61B/HSPA5	0.733661801612477
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/366	77/9376	1.33077851110638	GADD45A/PIK3R3/SHC3/CRK	0.587392385231771
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/366	32/9376	1.60109289617486	SEPTIN4/BID	0.686457975410637
Human Diseases	Immune disease	hsa05310	Asthma	2/366	32/9376	1.60109289617486	PRG2/HLA-DRB5	0.686457975410637
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/366	174/9376	1.17781546385277	EIF2AK3/ERO1B/P4HB/VCP/SEC61B/UBE2J1/HSP90B1/HSPA5	0.477163067792052
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/366	34/9376	1.50691096110575	RORA/NFIL3	0.596781009382445
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/366	57/9376	1.34828875467357	ACSL3/ELOVL7/ACADVL	0.531564549592237
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/366	105/9376	1.21988030184751	MAP1LC3B/EIF2AK3/RAB7B/VCP/FOXO3	0.45664790431505
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/366	82/9376	1.24963347994136	CTSS/HLA-DRB5/HLA-G/HSPA5	0.457585451957347
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/366	108/9376	1.18599473790731	EEF1A1/NXF1/NUP210L/TNPO3/IPO5	0.391817029795048
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/366	133/9376	1.15567607543449	GADD45A/PDPK1/PIK3R3/FOXO3/USP7/FBXO32	0.364422349646746
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/366	37/9376	1.38472899128637	UAP1/GFPT2	0.472573509866469
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/366	160/9376	1.1207650273224	VCAN/NRXN2/ITGB1/HLA-DRB5/CD28/HLA-G/CD274	0.310522967372741
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/366	62/9376	1.23955579058699	PIK3R3/ADCY3/FOXO3	0.381415366995882
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/366	62/9376	1.23955579058699	DLL3/TLE4/DTX4	0.381415366995882
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/366	38/9376	1.34828875467357	NMRK2/AOX1	0.433578862219738
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/366	138/9376	1.11380375386077	EIF4E/PDPK1/PIK3R3/CALM1/SHC3/CRK	0.271438181642731
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/366	65/9376	1.18234552332913	PBX1/ADCY3/ITPR2	0.297315400803556
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/366	90/9376	1.13855494839101	ABCB4/AQP9/SLC9A1/ADCY3	0.266190616073807
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/366	66/9376	1.16443119721808	RORA/NFATC1/HLA-DRB5	0.270174982229681
NA	NA	hsa04081	Hormone signaling	9/366	219/9376	1.05277341118347	CGA/CSH1/GNB1/PIK3R3/ADCY3/GNG4/ADRA2B/PRKG1/GPER1	0.159266487771149
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/366	17/9376	1.50691096110575	CA8	0.421604467967055
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/366	42/9376	1.21988030184751	CYP1B1/AOX1	0.287833180655476
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/366	119/9376	1.0763649722184	MAP2K3/TAB2/PIK3R3/CFLAR/CXCL1	0.168964836472373
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/366	43/9376	1.19151099250222	ACSL3/ACADVL	0.253676996630817
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/366	43/9376	1.19151099250222	ABCA1/CD36	0.253676996630817
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/366	18/9376	1.42319368548877	ACSL3	0.362199374904735
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/366	122/9376	1.04989698109827	PDPK1/PIK3R3/PAK3/NFATC1/CD28	0.1118029398896
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/366	71/9376	1.08242900023089	ATP6V1H/CXCL8/CXCL1	0.140512449072731
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/366	20/9376	1.28087431693989	LIPA	0.253422812210965
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/366	20/9376	1.28087431693989	UAP1	0.253422812210965
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/366	205/9376	0.999706783953085	PIK3R3/MAPKAPK2/HLA-G/USP7/JAK1/CHEK1/CCR5/ACTN1	-0.000855500176711272
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/366	128/9376	1.00068306010929	PDE4C/ADCY3/GUK1/NME2/AMPD3	0.00156820842591231
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/366	75/9376	1.02469945355191	GAPDH/ENO2/TPI1	0.0432829586748513
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/366	155/9376	0.991644632469593	TCF7L2/CAMK2A/PBX1/ADCY3/TCF7/ITPR2	-0.0211400583448603
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/366	103/9376	0.994853838399915	PIK3R3/CFLAR/CXCL8/CCL3L1	-0.0105841427276344
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/366	49/9376	1.04561168729787	OGT/GALNT13	0.0645159319697612
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/366	77/9376	0.998083883329785	GADD45A/PIK3R3/JAK1	-0.00340261626287453
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/366	78/9376	0.985287936107608	TPI1/MTMR14/MTMR4	-0.0262960137487357
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/366	78/9376	0.985287936107608	ENO2/BTG1/PNLDC1	-0.0262960137487357
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/366	23/9376	1.11380375386077	ENPEP	0.110130807587542
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/366	79/9376	0.972815936916373	DHDH/CYP1B1/GSTO2	-0.0489012865214736
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/366	79/9376	0.972815936916373	ATP6V1H/CPLX1/SLC6A3	-0.0489012865214736
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/366	107/9376	0.957663040702722	LDHA/CAMK2A/CALM1/ITPR2	-0.0887685030704154
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/366	110/9376	0.931544957774466	THSD4/NBL1/ID4/FMOD	-0.145552417380988
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/366	83/9376	0.925933241161367	OGT/AUTS2/USP7	-0.136599214932602
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/366	250/9376	0.922229508196721	SNX32/EHD1/ASAP1/HLA-G/CAPZB/IL2RA/ARF1/ARFGAP3/CCR5	-0.251193503277426
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/366	85/9376	0.904146576663452	GUK1/NME2/AMPD3	-0.178916192013485
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/366	142/9376	0.902024166859078	UBE2O/CUL3/UBE2J1/ELOC/UBE2R2	-0.237100236785109
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/366	27/9376	0.948795790325845	ELOVL7	-0.0536993161254245
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/366	226/9376	0.906813675709657	CGA/PDE4C/PIK3R3/CAMK2A/SLC9A1/ADCY3/NFATC1/CALM1	-0.285798298828329
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/366	144/9376	0.88949605343048	PIK3R3/FGFR1/TCF7/ID4/JAK1	-0.269323917136278
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/366	28/9376	0.914910226385636	ELOVL7	-0.0908784303722493
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/366	28/9376	0.914910226385636	B3GNT5	-0.0908784303722493
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/366	117/9376	0.875811498762319	ACTG1/CHD3/RUVBL2/GATAD2A	-0.272430708648503
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/366	29/9376	0.88336159788958	SAV1	-0.126785102009225
NA	NA	hsa04981	Folate transport and metabolism	1/366	31/9376	0.826370527057994	SLC22A6	-0.19515443548158
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/366	32/9376	0.800546448087432	MGAM	-0.227779237295348
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/366	32/9376	0.800546448087432	LDHA	-0.227779237295348
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/366	32/9376	0.800546448087432	ATG16L1	-0.227779237295348
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/366	33/9376	0.776287464812055	VAMP5	-0.259458498417769
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/366	156/9376	0.821073280089674	PIK3R3/CFLAR/BID/JAK1/TYK2	-0.454188176664938
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/366	157/9376	0.815843513974453	ACTG1/TCF7L2/SAV1/TCF7/AREG	-0.468984752750146
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/366	35/9376	0.731928181108509	TPI1	-0.320222823584945
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/366	69/9376	0.742535835907183	CALM1/ITPR2	-0.432613694322445
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/366	191/9376	0.804737790747575	GNB1/GNG4/SLC6A3/CALM1/ADORA2B/SHC3	-0.549489106996398
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/366	36/9376	0.711596842744384	DHDH	-0.349415050929923
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/366	36/9376	0.711596842744384	MGAM	-0.349415050929923
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/366	36/9376	0.711596842744384	GALNT13	-0.349415050929923
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/366	70/9376	0.731928181108509	CD36/ACSL3	-0.453714273862472
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/366	70/9376	0.731928181108509	CYP1B1/GSTO2	-0.453714273862472
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/366	250/9376	0.81975956284153	ATP6V1H/LIPA/AP5Z1/CTSS/AP1G1/OSBPL6/CLN8/LAPTM5	-0.582164594723343
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/366	37/9376	0.692364495643184	GFPT2	-0.377877397716643
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/366	37/9376	0.692364495643184	AOX1	-0.377877397716643
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/366	73/9376	0.701848940788981	GSTO2/AOX1	-0.515406702029136
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/366	39/9376	0.656858624071739	CHDH	-0.432778321189592
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/366	138/9376	0.742535835907183	CAMK2A/ADCY3/CALM1/ITPR2	-0.614088746360834
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/366	41/9376	0.624816739970678	CHDH	-0.485223700232662
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/366	41/9376	0.624816739970678	CXCL8	-0.485223700232662
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/366	110/9376	0.698658718330849	PIK3R3/STK10/ADCY3	-0.640726388848384
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/366	44/9376	0.582215598609041	TAF4B	-0.559828468480242
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/366	82/9376	0.624816739970678	NME2/GSTO2	-0.687721861857946
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/366	116/9376	0.662521198417185	GAPDH/ENO2/TPI1	-0.737112515011353
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/366	46/9376	0.556901876930387	PSMD12	-0.607158095143814
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/366	47/9376	0.545052900825485	LDHA	-0.630167596901451
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/366	47/9376	0.545052900825485	PIK3R3	-0.630167596901451
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/366	48/9376	0.533697632058288	AOX1	-0.65276634659899
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/366	49/9376	0.522805843648935	SLC6A3	-0.67497230537557
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/366	51/9376	0.502303653701918	ENPP2	-0.718271948424833
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/366	54/9376	0.474397895162922	LDHA	-0.780662308953914
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/366	54/9376	0.474397895162922	RMI2	-0.780662308953914
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/366	55/9376	0.465772478887233	SGMS2	-0.800829630245348
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/366	59/9376	0.434194683708438	NME2	-0.878655773883239
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/366	59/9376	0.434194683708438	GSTO2	-0.878655773883239
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/366	61/9376	0.419958792439309	SLC8A2	-0.916001365984756
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/366	103/9376	0.497426919199958	NXF1/FUS	-1.03364519648331
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/366	104/9376	0.492643968053804	SGMS2/LPCAT3	-1.04859207630288
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/366	63/9376	0.406626767282505	DOT1L	-0.952395226250975
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/366	63/9376	0.406626767282505	PTGDS	-0.952395226250975
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/366	65/9376	0.394115174443043	MGLL	-0.987898613919423
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/366	66/9376	0.388143732406028	CYP1B1	-1.00533389661498
NA	NA	hsa04382	Cornified envelope formation	5/366	217/9376	0.590264662184281	S100A16/KRT19/S100A9/KRT10/ST14	-1.23075906818562
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/366	72/9376	0.355798421372192	CXCL8	-1.10590282509675
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/366	83/9376	0.308644413720456	ACSL3	-1.275047427562
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/366	83/9376	0.308644413720456	CCL4L2	-1.275047427562
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/366	86/9376	0.297877748125556	TAS1R1	-1.31831104622804
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/366	370/9376	0.553891596514547	CGA/CSH1/ADM/ADRA2B/OGFRL1/GRIK5/CHRNE/ADORA2B	-1.76457076796306
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/366	154/9376	0.332694627776595	RDH12/NME2	-1.68281435516985
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/366	158/9376	0.324271978972124	GADD45A/CHEK1	-1.72641780189097
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/366	243/9376	0.421687017922598	DDX5/HNRNPC/FUS/HNRNPA1	-1.84087006222589
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/366	183/9376	0.279972528292872	NXF1/GTPBP4	-1.98248434669703
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/366	449/9376	0.399381746930033	GNB1/SLC8A2/CAMK2A/ADCY3/CALM1/PRKG1/OR2B11	-2.62864970080754