category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/291	89/9376	6.15436889455191	COL6A1/COL6A3/FN1/CD44/COL1A2/LAMA2/COL4A1/ITGB1/LAMC1/SPP1/LAMB2/THBS2/TNXB/ITGAV/GP1BB/COL4A2/LAMB1	8.74384488964388
NA	NA	hsa04518	Integrin signaling	21/291	154/9376	4.39362699156514	COL6A1/COL6A3/FN1/FBN1/COL1A2/LAMA2/COL4A1/ITGB1/ITGAD/LAMC1/PDGFRB/LIMS1/SPP1/LAMB2/THBS2/TNXB/ITGAV/COL4A2/ITGAX/LAMB1/ICAM1	7.59943970750021
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/291	70/9376	5.98370152184585	ABL2/LAMA2/FYN/HLA-DRB5/PRF1/HLA-DMA/HLA-DRA/HLA-B/HLA-DQA1/HLA-DPB1/ICAM1/DTNA/SSPN	7.49012709368209
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/291	93/9376	4.85031223441599	STAT4/HLA-DRB5/IL2RB/CD247/HLA-DMA/HLA-DRA/JUN/HLA-DQA1/HLA-DPB1/PPP3CA/RUNX3/NFATC1/IL2RG/MAML2	6.67825372744781
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/291	103/9376	4.37940813398726	FN1/COL1A2/LAMA2/COL4A1/RAB7A/COL3A1/IL1R1/LAMC1/LAMB2/CXCL1/COL4A2/RAB7B/LAMB1/PLCB1	6.17189877186825
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/291	203/9376	3.17437746517021	COL6A1/COL6A3/FN1/PAK3/COL1A2/LAMA2/COL4A1/ITGB1/FYN/LAMC1/PDGFRB/SPP1/LAMB2/VAV3/THBS2/TNXB/ITGAV/COL4A2/JUN/LAMB1	5.6052750412544
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/291	45/9376	6.44398625429553	GZMB/HLA-DRB5/PRF1/HLA-DMA/HLA-DRA/KLRD1/HLA-B/HLA-DQA1/HLA-DPB1	6.55132054150472
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/291	101/9376	4.14711986662584	FN1/EGR1/COL1A2/COL4A1/COL3A1/FOXO1/MMP2/COL4A2/JUN/PLCG2/ICAM1/PLCB1/NFATC1	5.69097501759565
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/291	39/9376	6.60921667107234	GZMB/HLA-DRB5/PRF1/HLA-DMA/HLA-DRA/HLA-B/HLA-DQA1/HLA-DPB1	6.28203724770127
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	13/291	109/9376	3.84274409659825	RORA/HLA-DRB5/IL1R1/IL2RB/CD247/HLA-DMA/HLA-DRA/JUN/HLA-DQA1/HLA-DPB1/PPP3CA/NFATC1/IL2RG	5.34258081964746
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/291	66/9376	4.88180776840571	RORA/STAT4/HLA-DRB5/HLA-DMA/HLA-DRA/JUN/HLA-DQA1/HLA-DPB1/NFATC1/IL2RG	5.66370753499772
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/291	160/9376	3.22199312714777	ITGB1/HLA-DRB5/PTPRC/JAM2/HLA-DMA/NCAM1/NLGN1/HLA-DRA/ITGAV/HLA-B/HLA-DQA1/PECAM1/HLA-DPB1/ICAM1/VCAN/CADM1	5.07342373633931
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/291	233/9376	2.76565933660752	COL6A1/COL6A3/FBLN1/FN1/FBN1/COL1A2/LAMA2/COL4A1/ITGB1/COL3A1/THBS2/DIAPH2/ITGAV/COL4A2/SPTBN1/FMNL2/DTNA/VCAN/SSPN/FMNL3	4.88438830558587
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/291	54/9376	5.36998854524628	CGA/GZMB/HLA-DRB5/PRF1/HLA-DMA/HLA-DRA/HLA-B/HLA-DQA1/HLA-DPB1	5.7635796073128
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/291	44/9376	5.85816932208685	GZMB/HLA-DRB5/PRF1/HLA-DMA/HLA-DRA/HLA-B/HLA-DQA1/HLA-DPB1	5.7807113915282
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/291	133/9376	3.39157171278712	GZMB/FYN/CD247/KLRC2/PRF1/VAV3/LCP2/KLRD1/HLA-B/PLCG2/PPP3CA/ICAM1/NFATC1/KIR2DL4	4.97132800821195
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/291	122/9376	3.43327136499352	PAK3/FYN/PTPRC/CD247/VAV3/LCP2/CARD11/JUN/ITK/CBLB/PPP3CA/NFATC1/DLG1	4.84144920748264
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/291	232/9376	2.63870126792274	FN1/GSN/PAK3/ITGB1/ITGAD/PDGFRB/FGF10/BDKRB1/VAV3/DIAPH2/TIAM1/IQGAP2/ITGAV/ITGAX/EZR/C7/SPATA13/PIP4K2A/CYFIP2	4.52319530508028
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/291	362/9376	2.22513337510205	COL6A1/COL6A3/FN1/COL1A2/LAMA2/COL4A1/ITGB1/GNG4/CSH1/IL2RB/LAMC1/PDGFRB/YWHAB/SPP1/LAMB2/FGF10/THBS2/TNXB/ITGAV/COL4A2/LAMB1/ANGPT2/DDIT4/IRS1/IL2RG	4.25450017985604
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/291	116/9376	3.33309633842872	ITGB1/JAM2/VAV3/RHOH/MMP2/ITK/EZR/PECAM1/PLCG2/ICAM1/TXK/CTNND1	4.52507560955789
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/291	333/9376	2.22540065839035	COL6A1/COL6A3/FN1/COL1A2/LAMA2/COL4A1/ITGB1/TCF7L2/LAMC1/PDGFRB/SPP1/LAMB2/THBS2/FOXO1/TNXB/ITGAV/HLA-B/COL4A2/TCF7/LAMB1/CSNK1A1/DLG1/MAML2	4.074868775346
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/291	155/9376	2.91018734064959	RAB7A/ITGB1/HLA-DRB5/CORO1A/HLA-DMA/THBS2/HLA-DRA/ITGAV/HLA-B/HLA-DQA1/HLA-DPB1/RAB7B/MSR1/DYNC1H1	4.29163192686694
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/291	193/9376	2.67108238520022	CCL4/GNG4/XCL2/XCL1/VAV3/TIAM1/CXCL1/ITK/LYN/CCL5/PLCG2/CCL4L2/PLCB1/CXCL16/ELMO1/GRK3	4.19811074120609
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/291	82/9376	3.53633392004023	HLA-DRB5/KLRC2/HLA-DMA/HLA-DRA/KLRD1/HLA-B/HLA-DQA1/HLA-DPB1/KIR2DL4	4.12839923433497
NA	NA	hsa04517	IgSF CAM signaling	20/291	299/9376	2.15517934926272	PAK3/ITGB1/FYN/JAM2/NCAM1/VAV3/NLGN1/LCP2/FOXO1/EPB41L3/ITGAX/EZR/LYN/SPTBN1/CD96/PLCG2/ICAM1/CADM1/SRGAP3/DOK2	3.63315151542181
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/291	100/9376	3.22199312714777	CD44/HLA-DRB5/IL1R1/HLA-DMA/HLA-DRA/CD7/GP1BB/HLA-DQA1/CD37/HLA-DPB1	3.99790074863465
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/291	196/9376	2.46581106669472	GNG4/TCF7L2/CALM1/MAP1LC3B/HLA-B/CXCL1/JUN/LYN/TCF7/PLCG2/PPP3CA/ICAM1/CLEC2B/ANGPT2/NFATC1	3.71154181859147
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/291	103/9376	3.12814866713375	COL6A1/COL6A3/COL15A1/COL1A2/COL4A1/COL3A1/COL18A1/ACE2/COL4A2/FXYD2	3.88669187747342
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/291	224/9376	2.3014236622484	EGR1/HLA-DRB5/IL1R1/IL2RB/MSX1/HLA-DMA/HLA-DRA/HLA-B/JUN/HLA-DQA1/HLA-DPB1/PPP3CA/ICAM1/NFATC1/IL2RG/DLG1	3.52820953282011
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/291	93/9376	3.11805786498171	FN1/LAMA2/COL4A1/ITGB1/LAMC1/LAMB2/ITGAV/COL4A2/LAMB1	3.67370929176338
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/291	112/9376	2.87677957781051	LAMA2/ITGB1/HLA-DRB5/LAMC1/HLA-DMA/LAMB2/HLA-DRA/HLA-DQA1/HLA-DPB1/LAMB1	3.57596017963586
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/291	95/9376	3.05241454150841	HLA-DRB5/HLA-DMA/HLA-DRA/CXCL1/JUN/HLA-DQA1/CCL5/HLA-DPB1/ICAM1	3.59831489184439
Human Diseases	Immune disease	hsa05310	Asthma	5/291	32/9376	5.03436426116838	HLA-DRB5/HLA-DMA/HLA-DRA/HLA-DQA1/HLA-DPB1	4.09122485459637
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/291	157/9376	2.4626699061002	PBX1/RAB7A/ITGAV/C1QA/PECAM1/RAB7B/ATP8A2/SLC16A1/XKR6/ANO4/NFATC1/ELMO1	3.30768323179421
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/291	99/9376	2.92908466104342	CFD/HLA-DRB5/HLA-DMA/HLA-DRA/HLA-DQA1/C1QA/HLA-DPB1/ICAM1/DEFB1	3.45330369762261
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/291	205/9376	2.20038555024726	CD44/HLA-DRB5/CD247/HLA-DMA/HLA-DRA/HLA-B/JUN/HLA-DQA1/LYN/HLA-DPB1/PLCG2/ICAM1/ENTPD1/RUNX3	3.10999012188438
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/291	105/9376	2.76170839469809	CCL4/IL1R1/CXCL1/CARD11/LYN/PLCG2/ICAM1/CCL4L2/PLAU	3.24889031635868
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/291	105/9376	2.76170839469809	RAB7A/RABGEF1/MAP1LC3B/JUN/BNIP3L/USP15/RAB7B/OPTN/ARIH1	3.24889031635868
Organismal Systems	Immune system	hsa04611	Platelet activation	10/291	126/9376	2.55713740249823	COL1A2/ITGB1/FYN/COL3A1/LCP2/GP1BB/LYN/PLCG2/PLCB1/GUCY1A2	3.14927807491104
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/291	88/9376	2.92908466104342	CFD/PROCR/BDKRB1/SERPINE2/ITGAX/C1QA/C7/PLAU	3.25387741394287
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/291	212/9376	2.1277313103806	ITGB1/CALM1/SKAP1/PDGFRB/FGF10/VAV3/LCP2/TIAM1/DOCK4/PLCB1/EVL/ANGPT2/CTNND1/PRKD1	2.97235512162455
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/291	42/9376	3.83570610374734	MAP1LC3B/CP/PRNP/ACSL4/ACSL1	3.29626130133344
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/291	178/9376	2.17213019807715	SFRP2/TCF7L2/CTNND2/SFRP4/JUN/RSPO3/TCF7/PPP3CA/CSNK1A1/PLCB1/NFATC1/ROR2	2.82558788880575
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/291	248/9376	1.94878616561357	PAK3/RAB7A/PTPRC/TCF7L2/AHNAK2/RHOH/JUN/RAB7B/TCF7/ABI1/ACTR1B/ELMO1/DYNC1H1/NAIP/CYFIP2	2.71004208455311
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/291	78/9376	2.89153229359415	ITGB1/HLA-DRB5/HLA-DMA/HLA-DRA/JUN/HLA-DQA1/HLA-DPB1	3.0021746781063
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/291	98/9376	2.63019847114103	GSN/PTPRC/VAV3/LYN/PLCG2/MARCKS/AMPH/ASAP1	2.90332732900123
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/291	204/9376	2.05323091435887	DDX5/FN1/CD44/COL1A2/ITGB1/VAV3/TIAM1/ITGAV/TWIST2/MMP2/EZR/PLCG2/PLAU	2.72192607228285
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/291	100/9376	2.57759450171821	CCL4/XCL2/IL2RB/XCL1/CXCL1/CCL5/CCL4L2/IL2RG	2.83847243378162
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/291	86/9376	2.62255254535283	LAMA2/ITGB1/TCF7L2/ITGAV/TCF7/DTNA/SSPN	2.70526494882076
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/291	50/9376	3.22199312714777	HLA-DRB5/HLA-DMA/HLA-DRA/HLA-DQA1/HLA-DPB1	2.81935442303348
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/291	69/9376	2.80173315404154	FYN/VAV3/LCP2/LYN/PLCG2/ALOX5AP	2.68831295823536
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/291	71/9376	2.72281109336431	JAM2/CXCL1/JUN/LYN/CCL5/PLCG2	2.60782420542594
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/291	201/9376	1.92357798635688	DDX5/PBX1/ZEB1/GZMB/NFKBIZ/IL2RB/GRIA3/FOXO1/AFF1/MEF2C/WT1/PLAU	2.36885365857028
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/291	91/9376	2.47845625165213	VAV3/CARD11/JUN/LYN/PLCG2/PPP3CA/NFATC1	2.53634243020646
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/291	181/9376	1.9581173700898	RAB7A/HLA-DRB5/CALM1/CORO1A/HLA-DMA/HLA-DRA/HLA-DQA1/ITGAX/LSP1/HLA-DPB1/PPP3CA	2.32944146194857
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/291	105/9376	2.14799541809851	CALM1/JUN/CBLB/LSP1/PLCG2/PPP3CA/NFATC1	2.11709906605943
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/291	106/9376	2.1277313103806	ZEB1/TCF7L2/PDGFRB/FOXO1/TCF7/FOLR2/PLAU	2.08972130678725
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/291	130/9376	1.9827650013217	COL1A2/COL4A1/COL3A1/GNG4/MMP2/COL4A2/JUN/PLCB1	2.01936153846101
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/291	227/9376	1.70325627866842	CCL4/GNG4/IL1R1/CALM1/ITGAV/HLA-B/AKAP13/CCL5/PPP3CA/CCL4L2/PLCB1/NFATC1	1.91959407115451
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/291	253/9376	1.65556959102454	CD44/ITGB1/IL1R1/MAP1LC3B/FOXO1/SEPTIN11/JUN/CCL5/PLCG2/PLCB1/HK1/ELMO1/NAIP	1.89182033954677
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/291	180/9376	1.78999618174876	PILRA/HLA-DRB5/HLA-DMA/HLA-DRA/SOCS3/HLA-B/HLA-DQA1/CCL5/HLA-DPB1/POU2F1	1.91527628108093
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/291	184/9376	1.75108322127596	PAK3/ITGB1/FYN/SEMA5A/TRPC4/SEMA4D/PLCG2/PPP3CA/RGS3/SRGAP3	1.84145720646629
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/291	48/9376	2.68499427262314	AOX1/BCAT1/ALDH9A1/ABAT	2.09456791129564
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/291	48/9376	2.68499427262314	FXYD2/PLCB1/SLC2A5/HK1	2.09456791129564
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/291	69/9376	2.33477762836795	CALM1/ACE/PPP3CA/PLCB1/GUCY1A2	1.99158237536739
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/291	138/9376	1.86782210269436	FN1/ITGB1/VAV3/LCP2/JUN/SKAP2/NFATC1/ELMO1	1.83802298543601
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/291	238/9376	1.6245343498224	RPL13A/RPS20/CFD/RPS26/RPL18A/ACE2/ACE/RPS29/JUN/C1QA/C7/PLCG2	1.74658167154862
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/291	93/9376	2.07870524332114	FYN/TCF7L2/TCF7/ARHGAP29/CTNND1/PTPRJ	1.87098263035272
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/291	93/9376	2.07870524332114	CGA/EGR1/CALM1/MMP2/JUN/PLCB1	1.87098263035272
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/291	140/9376	1.84113892979872	EGR1/GNG4/CALM1/SPP1/MAP1LC3B/PLCB1/MEF2C/HDAC4	1.79456608611087
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/291	216/9376	1.6408298332697	CALM1/VAV3/CXCL1/JUN/LYN/CCL5/PPP3CA/ICAM1/PLCB1/NFATC1/POU2F1	1.70526362162902
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/291	142/9376	1.81520739557621	FYN/IL1R1/LCP2/SOCS3/JUN/PLCG2/PPP3CA/NFATC1	1.75181005552869
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/291	142/9376	1.81520739557621	IL1R1/CALM1/ITGAV/MMP2/JUN/PECAM1/ICAM1/MEF2C	1.75181005552869
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/291	122/9376	1.84868458115036	FOXO1/ITGAV/PLCG2/MED13/FXYD2/PLCB1/NCOA3	1.68861695901479
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/291	275/9376	1.52312402374258	EGR1/FYN/MT-CO3/LAMC1/NCAM1/C1QA/C7/CCL5/PRNP/PPP3CA/MT-ND4L/MCU/MT-ATP8	1.57578194988479
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/291	99/9376	1.95272310736228	PRKCH/IL1R1/CALM1/BDKRB1/PLCG2/PLCB1	1.70549395571116
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/291	99/9376	1.95272310736228	LAMA2/ITGB1/ACE/ITGAV/DTNA/SSPN	1.70549395571116
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/291	200/9376	1.61099656357388	PAK3/ITGB1/FYN/IL1R1/JUN/EZR/SEC24A/ABI1/NAIP/CYFIP2	1.56313587269435
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/291	103/9376	1.87688920028025	CD247/ACE/JUN/C1QA/CCL5/PLCB1	1.60148498307859
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/291	205/9376	1.57170396446232	COL1A2/COL3A1/MT-CO3/GFPT2/ACE/MMP2/MT-ND4L/PLCB1/IRS1/MT-ATP8	1.48118550890065
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/291	18/9376	3.57999236349752	ACSL4/ACSL1	1.96079783848903
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/291	38/9376	2.54367878459034	AOX1/NMRK1/NAMPT	1.70644174144907
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/291	60/9376	2.14799541809851	GRIA3/LYN/PLCB1/GUCY1A2	1.59650655797595
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/291	86/9376	1.87325181810917	PAK3/ABL2/JUN/CBLB/PLCG2	1.45596365540878
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/291	298/9376	1.40556747157453	CCL4/IL1R1/XCL2/CSH1/IL2RB/XCL1/CXCL1/CCL5/CCL4L2/BMP8A/BMP8B/CXCL16/IL2RG	1.27334423078968
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/291	138/9376	1.63434433985756	RHOQ/CALM1/FOXO1/SOCS3/CBLB/HK1/IRS1	1.34352360203721
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/291	42/9376	2.3014236622484	CYP1B1/AOX1/ALDH9A1	1.51279162845547
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/291	65/9376	1.9827650013217	CGA/SPP1/TRPC4/PLCB1	1.42291141577894
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/291	166/9376	1.55276777211941	CALM1/PPP3CA/FXYD2/PLCB1/MEF2C/NFATC1/IRS1/GUCY1A2	1.28598709473337
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/291	115/9376	1.68103989242492	EGR1/AKAP13/WNK1/KL/PLCB1/MEF2C	1.31511035310923
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/291	90/9376	1.78999618174876	FOXO1/KL/IRS1/SESN2/SESN1	1.34772589887841
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/291	43/9376	2.247902181731	ALDH9A1/ACSL4/ACSL1	1.4678233960042
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/291	168/9376	1.53428244149894	STAT4/CSH1/IL2RB/AOX1/PDGFRB/SOCS3/PIAS1/IL2RG	1.25058309669854
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/291	116/9376	1.66654816921436	GNG4/SLC38A1/GRIA3/PPP3CA/PLCB1/GRK3	1.29278024804526
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/291	250/9376	1.41767697594502	RAB7A/IL2RB/IQSEC1/HLA-B/CBLB/VPS37B/FOLR2/AMPH/ASAP1/IL2RG/GRK3	1.19795353893174
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/291	143/9376	1.57719943286954	HLA-DRB5/HLA-DMA/HLA-DRA/HLA-DQA1/C1QA/C7/HLA-DPB1	1.24477874367066
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/291	23/9376	2.80173315404154	ACE2/ACE	1.54827673464409
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/291	226/9376	1.4256606757291	CGA/CALM1/PDE10A/VAV3/GRIA3/TIAM1/JUN/FXYD2/LHCGR/NFATC1	1.15924937265888
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/291	69/9376	1.86782210269436	CALM1/GRIA3/JUN/PPP3CA	1.29485179249941
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/291	173/9376	1.48993901833423	HLA-DRB5/HLA-DMA/HLA-DRA/SOCS3/HLA-DQA1/CCL5/HLA-DPB1/ICAM1	1.16404571130406
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/291	70/9376	1.84113892979872	SOCS3/ACSL4/ACSL1/IRS1	1.26416830141599
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/291	71/9376	1.81520739557621	LDHA/PDGFRB/HK1/SLC7A5	1.23398182587411
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/291	47/9376	2.05659135775389	SOCS3/HK1/IRS1	1.29959521432075
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/291	97/9376	1.6608211995607	GNG4/CALM1/GRIA3/PLCB1/GUCY1A2	1.17081671410782
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/291	49/9376	1.97264885335578	GALNT17/GALNT13/ST6GAL1	1.22166687311065
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/291	50/9376	1.93319587628866	THBS2/PECAM1/ICAM1	1.18407653436278
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/291	154/9376	1.46454233052171	CALM1/JUN/PPP3CA/PLCB1/MEF2C/NFATC1/GUCY1A2	1.04026206803395
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/291	323/9376	1.29677741959508	CYP1B1/CD44/ZEB1/PDGFRB/TNXB/FOXP1/EZR/PLCG2/MARCKS/DDIT4/IRS1/PLAU/HDAC4	0.971416603718198
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/291	238/9376	1.353778624852	PAK3/ABL2/GNG4/CALM1/PDGFRB/FGF10/TIAM1/PLCG2/ANGPT2/RALGAPA2	0.9893823488298
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/291	76/9376	1.69578585639356	FADS2/SLC27A4/ACSL4/ACSL1	1.08996006240761
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/291	157/9376	1.43655744522512	CALM1/FOXO1/HLA-B/PPP3CA/MCU/NFATC1/KIR2DL4	0.987231456163644
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/291	52/9376	1.8588421887391	CYP1B1/CGA/LHCGR	1.11143373925434
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/291	214/9376	1.35504383852009	PAK3/GNG4/CALM1/CD247/HLA-B/JUN/PLCG2/PPP3CA/NFATC1	0.940293404979666
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/291	78/9376	1.65230416776809	FN1/ITGB1/SEPTIN11/ELMO1	1.03531462905953
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/291	78/9376	1.65230416776809	ITGB1/CALM1/JUN/C1QA	1.03531462905953
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/291	187/9376	1.37839278166749	MAP1LC3B/CXCL1/JUN/CCL5/NAMPT/PLCB1/MCU/NAIP	0.935403924047885
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/291	53/9376	1.82376969461194	KL/FXYD2/PLCB1	1.07630552677182
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/291	29/9376	2.22206422561915	RASSF4/RASSF2	1.17957775907695
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/291	105/9376	1.53428244149894	LAMA2/ITGB1/ITGAV/DTNA/SSPN	0.985307815760192
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/291	107/9376	1.50560426502232	LDHA/CALM1/FOXO1/PPP3CA/PLCB1	0.941360223187678
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/291	31/9376	2.07870524332114	ALDH9A1/KL	1.07662299309299
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/291	31/9376	2.07870524332114	ALDH9A1/ABAT	1.07662299309299
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/291	109/9376	1.47797849869164	CCL4/SPP1/JUN/CCL5/CCL4L2	0.898300611148789
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/291	109/9376	1.47797849869164	GFPT2/FOXO1/SOCS3/SLC27A4/IRS1	0.898300611148789
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/291	56/9376	1.7260677466863	MGAT4C/MGAT5/ST6GAL1	0.975287974240711
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/291	56/9376	1.7260677466863	SCUBE2/CSNK1A1/GRK3	0.975287974240711
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/291	110/9376	1.46454233052171	LDHA/PLCG2/ANGPT2/HK1/PFKFB3	0.877092012298005
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/291	110/9376	1.46454233052171	FBN1/THSD4/FMOD/BMP8A/BMP8B	0.877092012298005
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/291	57/9376	1.69578585639356	FADS2/ACSL4/ACSL1	0.94297034535818
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/291	32/9376	2.01374570446735	LDHA/ABAT	1.0280335026456
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/291	254/9376	1.26850123116054	CALM1/PDGFRB/FGF10/BDKRB1/PLCG2/PPP3CA/PLCB1/LHCGR/MCU/NFATC1	0.776404015112362
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/291	10/9376	3.22199312714777	PAPSS2	1.25815834191569
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/291	169/9376	1.33455336627422	RAB7A/MAP1LC3B/RAB7B/OPTN/DAPK2/DDIT4/IRS1	0.785451460730844
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/291	59/9376	1.63830159007514	CGA/MGLL/IRS1	0.880204432530146
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/291	34/9376	1.8952900747928	RORA/RORB	0.935950679310191
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/291	144/9376	1.34249713631157	TCF7L2/FOXO1/CXCL1/C1QA/TCF7/ALDH9A1	0.74124189834875
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/291	35/9376	1.84113892979872	HK1/PFKFB3	0.892225716241669
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/291	205/9376	1.25736317156986	GSN/YWHAB/HDAC9/HLA-B/JUN/LYN/DLG1/HDAC4	0.666783202408788
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/291	90/9376	1.43199694539901	CD247/JUN/PPP3CA/NFATC1	0.736982639918336
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/291	235/9376	1.23395481465234	MT-CO3/COA1/BMP8A/MT-ND4L/BMP8B/MGLL/ACSL4/ACSL1/MT-ATP8	0.650037977931827
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/291	36/9376	1.78999618174876	GALNT17/GALNT13	0.849909084563287
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/291	119/9376	1.353778624852	SOCS3/CXCL1/JUN/CCL5/ICAM1	0.695087702746379
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/291	63/9376	1.53428244149894	PRDM6/ALDH9A1/SMYD3	0.761493221909064
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/291	148/9376	1.30621342992477	TCF7L2/FGF10/JUN/TCF7/CSNK1A1/NCOA3	0.672002619152087
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/291	91/9376	1.41626071522979	PDE8B/GNG4/PDE10A/GRK3	0.714109540194779
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/291	12/9376	2.68499427262314	NCAM1	1.04526886974017
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/291	120/9376	1.34249713631157	CALM1/JUN/PLCG2/MATK/IRS1	0.675780353290946
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/291	37/9376	1.74161790656636	GFPT2/ABAT	0.808910641269854
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/291	37/9376	1.74161790656636	GFPT2/HK1	0.808910641269854
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/291	37/9376	1.74161790656636	ICAM1/PLCB1	0.808910641269854
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/291	37/9376	1.74161790656636	TCF7L2/TCF7	0.808910641269854
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/291	93/9376	1.38580349554743	CALM1/FXYD2/PLCB1/GUCY1A2	0.669164856078949
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/291	65/9376	1.48707375099128	PDE8B/PBX1/PLCB1	0.705217218439476
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/291	122/9376	1.32048898653597	CSH1/SOCS3/PLCG2/PLCB1/IRS1	0.637672876192178
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/291	38/9376	1.69578585639356	GFPT2/HK1	0.76914837485115
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/291	38/9376	1.69578585639356	FXYD2/IRS1	0.76914837485115
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/291	38/9376	1.69578585639356	PTPRC/IL2RG	0.76914837485115
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/291	67/9376	1.44268348976766	LDHA/ALDH9A1/HK1	0.650801998623931
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/291	67/9376	1.44268348976766	CALM1/PPP3CA/PLCB1	0.650801998623931
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/291	157/9376	1.2313349530501	TCF7L2/YWHAB/TCF7/BMP8A/BMP8B/DLG1	0.523141101037531
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/291	98/9376	1.31509923557052	CALM1/PLCG2/PLCB1/PIP4K2A	0.561180885747582
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/291	41/9376	1.57170396446232	MMP2/DAPK2	0.656561840598786
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/291	128/9376	1.2585910652921	PDE8B/PDE10A/PAPSS2/ENTPD1/GUCY1A2	0.52718647082187
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/291	71/9376	1.36140554668215	CGA/SOCS3/LHCGR	0.547060636098201
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/291	101/9376	1.27603688203872	TCF7L2/CALM1/TCF7/PLCB1	0.499160841084073
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/291	133/9376	1.21127561170969	GNG4/CALM1/GRIA3/PPP3CA/PLCB1	0.439175777305227
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/291	227/9376	1.13550418577895	CYP1B1/ABL2/MT-CO3/JUN/MT-ND4L/PRKD1/MT-ATP8/PTPRJ	0.369869476502077
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/291	75/9376	1.28879725085911	CGA/FXYD2/PLCB1	0.449395305265433
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/291	17/9376	1.8952900747928	PAPSS2	0.661215725685229
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/291	76/9376	1.27183939229517	CALM1/EZR/PLCB1	0.425840908187843
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/291	76/9376	1.27183939229517	CALM1/PDGFRB/PLCG2	0.425840908187843
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/291	47/9376	1.37106090516926	LDHA/ALDH9A1	0.456400644431376
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/291	170/9376	1.13717404487568	ITGB1/JAM2/TIAM1/JUN/EZR/DLG1	0.323020873518534
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/291	139/9376	1.15899033350639	CALM1/MMP2/JUN/PLCB1/NCOA3	0.337973240311822
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/291	78/9376	1.23922812582606	PLCG2/PLCB1/PIP4K2A	0.379694612710608
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/291	144/9376	1.11874761359297	RORA/GRIA3/PLCB1/MCU/DAB1	0.256996912359489
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/291	51/9376	1.26352671652854	KDELR2/PLCG2	0.337718604117171
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/291	83/9376	1.16457582908955	PRDX5/ACSL4/ACSL1	0.269523598308384
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/291	83/9376	1.16457582908955	CCL4/CCL5/CCL4L2	0.269523598308384
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/291	115/9376	1.12069326161661	FYN/GNG4/KCNQ5/PLCB1	0.233062643859778
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/291	21/9376	1.53428244149894	CHST15	0.438660288797173
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/291	21/9376	1.53428244149894	BCAT1	0.438660288797173
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/291	149/9376	1.08120574736502	GNG4/GRIA3/MT-ND4L/PLCB1/MGLL	0.178821324969273
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/291	22/9376	1.46454233052171	ALDH9A1	0.390398031241052
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/291	54/9376	1.19333078783251	LDHA/BCAT1	0.254984051944318
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/291	87/9376	1.11103211280957	TCF7L2/JUN/TCF7	0.186205890612676
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/291	23/9376	1.40086657702077	PCYOX1	0.344475203503616
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/291	23/9376	1.40086657702077	FXYD2	0.344475203503616
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/291	56/9376	1.1507118311242	CXCL1/NAIP	0.202443142726098
NA	NA	hsa04081	Hormone signaling	7/291	219/9376	1.02986081689655	CGA/GNG4/CSH1/ITGAV/PLCB1/LHCGR/IRS1	0.0800233635357854
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/291	89/9376	1.08606509903857	PDGFRB/PLCB1/GUCY1A2	0.146000391473832
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/291	89/9376	1.08606509903857	GNG4/SLC38A1/ABAT	0.146000391473832
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/291	155/9376	1.03935262166057	PDE8B/PBX1/TCF7L2/TCF7/PLCB1	0.0884138240948572
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/291	24/9376	1.34249713631157	EXT1	0.30066299775193
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/291	59/9376	1.09220106005009	TCF7L2/TCF7	0.127143317519411
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/291	26/9376	1.23922812582606	FADS2	0.218606350152454
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/291	60/9376	1.07399770904926	PLCG2/PPP3CA	0.10290792620759
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/291	61/9376	1.05639118922878	FXYD2/MT1G	0.0790777690113958
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/291	27/9376	1.19333078783251	ABAT	0.180040408551513
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/291	27/9376	1.19333078783251	FADS2	0.180040408551513
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/291	62/9376	1.03935262166057	FOXO1/IRS1	0.0556379429764244
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/291	62/9376	1.03935262166057	DTX4/MAML2	0.0556379429764244
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/291	63/9376	1.02285496099929	TCF7L2/TCF7	0.0325743399673199
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/291	300/9376	0.96659793814433	IL1R1/PDGFRB/FGF10/PTPN5/JUN/PPP3CA/ANGPT2/MEF2C/NFATC1	-0.105234060114633
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/291	98/9376	0.986324426677888	CALM1/PLCB1/PRKD1	-0.0243557250658309
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/291	99/9376	0.976361553681141	MMP2/JUN/NCOA3	-0.0423157862002879
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/291	99/9376	0.976361553681141	PDGFRB/JUN/SLC22A3	-0.0423157862002879
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/291	29/9376	1.11103211280957	CALM1	0.107171953869399
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/291	134/9376	0.961788993178438	PRKCH/CALM1/PLCB1/GUCY1A2	-0.0797310649714941
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/291	65/9376	0.991382500660851	ALDH9A1/MGLL	-0.0124769788999928
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/291	30/9376	1.07399770904926	FOLR2	0.0726500102949131
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/291	136/9376	0.947645037396402	IL2RB/JUN/CBLB/IL2RG	-0.11006797820424
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/291	102/9376	0.947645037396402	RAB27B/FXYD2/PLCB1	-0.0951467724209875
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/291	137/9376	0.940727920335114	GZMB/CTSW/PRF1/JUN	-0.125074170813504
NA	NA	hsa04981	Folate transport and metabolism	1/291	31/9376	1.03935262166057	FOLR2	0.0392766583648147
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/291	68/9376	0.947645037396402	TCF7L2/TCF7	-0.0775449980931243
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	14/291	480/9376	0.939747995418099	CALM1/MT-CO3/MAP1LC3B/GRIA3/PRNP/PPP3CA/CSNK1A1/OPTN/MT-ND4L/PLCB1/MCU/ACTR1B/HIP1/MT-ATP8	-0.242529403647542
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/291	32/9376	1.00687285223368	HK1	0.00696971866200404
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/291	70/9376	0.920569464899362	PAK3/JUN	-0.11937809686536
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/291	33/9376	0.976361553681141	BCAT1	-0.0243445858492453
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/291	33/9376	0.976361553681141	VAMP5	-0.0243445858492453
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/291	142/9376	0.907603697788103	SOCS3/CBLB/UBE2W/PIAS1	-0.198551647331489
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/291	73/9376	0.882737843054182	PDGFRB/FGF10	-0.180002055668268
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/291	36/9376	0.89499809087438	KL	-0.112965199736541
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/291	36/9376	0.89499809087438	HK1	-0.112965199736541
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/291	75/9376	0.859198167239404	SESN2/SESN1	-0.219100709674865
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/291	149/9376	0.864964597892018	FYN/PDGFRB/PLCG2/PLCB1	-0.297358380487104
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/291	37/9376	0.87080895328318	AOX1	-0.14091355065828
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/291	150/9376	0.859198167239404	TCF7L2/FGF10/TCF7/CSNK1A1	-0.311112083383667
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/291	115/9376	0.840519946212461	GNG4/KCND2/PLCB1	-0.30796121076495
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/291	78/9376	0.826152083884043	BTG1/CNOT8	-0.275925403638316
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/291	39/9376	0.826152083884043	SARDH	-0.19470081983246
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/291	80/9376	0.805498281786942	PDGFRB/PLCG2	-0.312672758430273
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/291	157/9376	0.820889968700068	MT-CO3/SOCS3/JUN/IRS1	-0.405039609214695
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/291	41/9376	0.785851982231162	SARDH	-0.245933954365914
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/291	41/9376	0.785851982231162	GRIA3	-0.245933954365914
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/291	158/9376	0.815694462569055	DDIT4/IRS1/SESN2/SLC7A5	-0.41813665646343
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/291	83/9376	0.776383886059703	AUTS2/JARID2	-0.366213070305303
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/291	122/9376	0.792293391921582	FOXO1/IRS1/PFKFB3	-0.413271206630438
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/291	43/9376	0.749300727243667	SLC27A4	-0.294880691211346
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/291	308/9376	0.836881331726693	TGM2/MT-CO3/GRIA3/MT-ND4L/PLCB1/ACTR1B/HIP1/MT-ATP8	-0.520946274463173
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/291	163/9376	0.790673160036262	STAT4/YWHAB/JUN/NFATC1	-0.482489482433564
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/291	44/9376	0.732271165260856	MGAT4C	-0.318569202143892
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/291	44/9376	0.732271165260856	DYNC1H1	-0.318569202143892
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/291	86/9376	0.749300727243667	FXYD2/PLCB1	-0.417988284709191
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/291	87/9376	0.740688075206383	MT-CO3/FXYD2	-0.434877862636861
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/291	45/9376	0.715998472699504	DEFB1	-0.341768871689265
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/291	46/9376	0.700433288510384	CP	-0.364503172653599
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/291	170/9376	0.758116029917121	TCF7L2/TCF7/PLCG2/CSNK1A1	-0.569594425659118
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/291	49/9376	0.657549617785258	JUN	-0.430124691138459
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/291	250/9376	0.773278350515464	RAB7A/CTSW/OSBPL3/PSAP/GNPTAB/DMXL1	-0.650268073163305
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/291	50/9376	0.644398625429553	ALDH9A1	-0.451201354307926
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/291	94/9376	0.685530452584631	CXCL1/JUN	-0.548392374562269
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/291	52/9376	0.619614062913032	MYLIP	-0.492260126434901
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/291	138/9376	0.700433288510384	MT-CO3/MT-ND4L/MT-ATP8	-0.634473931557968
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/291	138/9376	0.700433288510384	CALM1/YWHAB/PPP3CA	-0.634473931557968
NA	NA	hsa04519	Cadherin signaling	10/291	404/9376	0.7975230512742	TCF7L2/PDGFRB/YWHAB/VAV3/CTNND2/TCF7/CSNK1A1/EVL/CTNND1/CYFIP2	-0.744545605178879
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/291	54/9376	0.596665393916253	REV3L	-0.53195817025118
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/291	55/9376	0.585816932208685	PSAP	-0.551330600975996
Genetic Information Processing	Translation	hsa03010	Ribosome	5/291	222/9376	0.725674127735983	RPL13A/RPS20/RPS26/RPL18A/RPS29	-0.740299521778068
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/291	59/9376	0.546100530025045	ENTPD1	-0.625917797491324
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/291	191/9376	0.674762958564977	GNG4/CALM1/HDAC9/HDAC4	-0.812730900065839
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	9/291	388/9376	0.747369539802317	CALM1/MT-CO3/PPP3CA/CSNK1A1/MT-ND4L/PLCB1/MCU/IRS1/MT-ATP8	-0.909577504640558
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/291	195/9376	0.660921667107234	HDAC9/PLCG2/PLCB1/HDAC4	-0.856331693907069
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/291	154/9376	0.627660998795019	CALM1/FXYD2/PLCB1	-0.833788686099266
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/291	63/9376	0.511427480499645	PTGDS	-0.696344541974424
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/291	156/9376	0.619614062913032	YWHAB/SOCS3/PIAS1	-0.857414765422795
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/291	66/9376	0.488180776840571	CYP1B1	-0.746764024318314
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/291	68/9376	0.473822518698201	AOX1	-0.77934220091275
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/291	368/9376	0.700433288510384	MT-CO3/MAP1LC3B/PPP3CA/OPTN/MT-ND4L/MCU/ACTR1B/MT-ATP8	-1.04923541121727
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/291	70/9376	0.460284732449681	CYP1B1	-0.811151296006037
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/291	72/9376	0.44749904543719	RNF125	-0.842236574488663
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/291	73/9376	0.441368921527091	AOX1	-0.857520832844376
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/291	73/9376	0.441368921527091	MAP1B	-0.857520832844376
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/291	73/9376	0.441368921527091	PLCG2	-0.857520832844376
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/291	125/9376	0.515518900343643	FYN/PLCB1	-0.975904166399934
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/291	75/9376	0.429599083619702	BCAT1	-0.887596724615163
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/291	75/9376	0.429599083619702	REV3L	-0.887596724615163
NA	NA	hsa04382	Cornified envelope formation	4/291	217/9376	0.59391578380604	COL4A1/PCSK6/COL4A2/SLC27A4	-1.08315750650877
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/291	79/9376	0.407847231284527	CYP1B1	-0.945900731400875
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/291	133/9376	0.484510244683875	FOXO1/IRS1	-1.07154163299701
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/291	268/9376	0.601118120736523	CALM1/MT-CO3/MT-ND4L/MCU/MT-ATP8	-1.18568645926964
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/291	85/9376	0.379058014958561	ENTPD1	-1.02919798054978
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/291	86/9376	0.374650363621833	PLCB1	-1.04263893141518
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/291	144/9376	0.44749904543719	TCF7/JARID2	-1.1957380456083
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/291	90/9376	0.357999236349752	FXYD2	-1.0952471369619
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/291	194/9376	0.498246359868211	KIF26B/ACTR1B/DYNC1H1	-1.26384094007304
NA	NA	hsa04082	Neuroactive ligand signaling	3/291	199/9376	0.485727607107703	GNG4/GRIA3/PLCB1	-1.31231789331201
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/291	217/9376	0.44543683785453	CYP1B1/FGF10/JUN	-1.47919871779552
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/291	108/9376	0.298332696958126	RANBP17	-1.3125618324207
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/291	174/9376	0.370344037603192	SEC24A/HSPBP1	-1.50039806961878
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/291	116/9376	0.277758028202394	HK1	-1.40079921988193
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/291	370/9376	0.522485371969908	CGA/GZMA/CSH1/BDKRB1/GRIA3/LHCGR	-1.67722465460398
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/291	154/9376	0.209220332931673	BCAT1	-1.77081406316587
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/291	158/9376	0.203923615642264	YWHAB	-1.80607008495096
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/291	168/9376	0.191785305187367	STAT4	-1.89177026480677
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/291	243/9376	0.265184619518335	DDX5/HNRNPC	-2.07703738152023
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/291	449/9376	0.215277937225909	CALM1/NCALD/GRK3	-3.0496916672895