category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore NA NA hsa04382 Cornified envelope formation 21/223 217/9376 4.06885577896716 KRT19/KRT7/DSG2/KRT8/DSP/PADI1/PRSS8/PCSK6/CLDN19/JUP/PKP3/KRT18/S100A11/PKP2/CLDN4/KRT17/S100A6/CLDN7/LAMA5/SPTLC3/CLDN6 7.13902092941234 NA NA hsa04519 Cadherin signaling 25/223 404/9376 2.60178484216135 KRT19/KRT7/DSG2/KRT8/DSP/JUP/FLT4/PKP3/KRT18/ERBB2/TEAD3/FAT2/PKP2/WNT7A/CDH1/TCF7L1/KRT17/LIMA1/TMC1/NCKAP1/ARPC1A/MPDZ/TEAD1/CDH5/WWTR1 5.13696454450603 Organismal Systems Digestive system hsa04978 Mineral absorption 8/223 61/9376 5.51407777696097 MT1F/MT1H/MT1E/MT1G/ATP1A4/MT1X/SLC6A19/MT1M 5.52075995288361 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 13/223 160/9376 3.41614349775785 HLA-G/PTPRF/CLDN19/ESAM/CDH1/CLDN4/CLDN7/MAG/CD274/PTPRS/CDH5/CLDN6/JAM3 4.81135964033334 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 13/223 170/9376 3.21519388024268 CLDN19/ERBB2/MYL6/CLDN4/CLDN7/ARPC1A/PARD3/MYH10/MPDZ/PRKCZ/CLDN6/JAM3/PRKAB2 4.5494307308823 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 9/223 93/9376 4.06885577896716 PTPRF/ERBB2/ARHGAP29/CDH1/TCF7L1/HEG1/PARD3/CDH5/MYL10 4.64226701632033 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 9/223 116/9376 3.26209989175816 CLDN19/ESAM/CLDN4/CLDN7/GNAI1/CDH5/MYL10/CLDN6/JAM3 3.82641102133962 NA NA hsa04518 Integrin signaling 10/223 154/9376 2.73018461359269 PGF/FLT4/FLT1/ERBB2/FN1/CDH1/LAMA5/COL9A3/LAMB1/COL1A2 3.37906530799655 Environmental Information Processing Signal transduction hsa04392 Hippo signaling pathway - multiple species 4/223 29/9376 5.79928869645895 RASSF6/TEAD3/TEAD1/WWTR1 4.04013699298995 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 17/223 362/9376 1.97448157966454 PGF/CSH1/EFNA1/FLT4/FLT1/ERBB3/CCNE1/IGF2/ERBB2/CSH2/FN1/FGFR3/GNG12/LAMA5/COL9A3/LAMB1/COL1A2 2.95138238650736 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 11/223 203/9376 2.27829198789459 PGF/FLT4/FLT1/ERBB2/FN1/LAMA5/COL9A3/LAMB1/CAV1/COL1A2/MYL10 2.87394681987144 Organismal Systems Development and regeneration hsa04360 Axon guidance 10/223 184/9376 2.28504581789823 EFNA1/SEMA4C/RHOD/EPHB3/SEMA4B/NTN4/GNAI1/PARD3/PRKCZ/CFL1 2.74776036506493 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 9/223 157/9376 2.41021393276399 RASSF6/TEAD3/WNT7A/CDH1/TCF7L1/PARD3/TEAD1/PRKCZ/WWTR1 2.78130911065926 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 11/223 233/9376 1.98494967185666 DSG2/DSP/JUP/TPM1/BGN/FN1/PKP2/ATP1A4/COL9A3/MYH10/COL1A2 2.37631483368133 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 10/223 204/9376 2.06102171810428 ERBB3/IGF2/ERBB2/GPC3/FN1/WNT7A/GPC1/CAV1/COL1A2/TIMP3 2.39146303759915 NA NA hsa04517 IgSF CAM signaling 13/223 299/9376 1.82803665431858 PTPRF/ESAM/CDH1/MYL6/MTSS2/ARPC1A/MAG/PARD3/MYH10/PTPRS/MPDZ/TUBB3/JAM3 2.27127817068097 NA NA hsa03272 Virion - Hepatitis viruses 4/223 48/9376 3.50373692077728 CLDN19/CLDN4/CLDN7/CLDN6 2.7143845965263 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 5/223 76/9376 2.76610809535048 PPARG/ANGPTL4/SLC27A6/PLIN2/CYP8B1 2.41289787878983 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 6/223 103/9376 2.44921415821324 FN1/PRDX1/LAMA5/LAMB1/COL1A2/NOS2 2.30832730728148 Cellular Processes Transport and catabolism hsa04144 Endocytosis 11/223 250/9376 1.8499730941704 HLA-G/FOLR1/ASAP3/ZFYVE9/FGFR3/CHMP4C/ARPC1A/PARD3/PRKCZ/CAV1/ARF4 2.12613721393511 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 5/223 78/9376 2.69518224675175 SEPTIN3/FN1/CDH1/ARPC1A/CAV1 2.34652542607079 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 6/223 109/9376 2.3143950302382 PTPRF/PPP1R3B/SLC27A6/PYGL/PRKCZ/PRKAB2 2.15439788650234 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 6/223 110/9376 2.29335507541786 FLT1/ERBB2/EPAS1/EGLN3/NOS2/GAPDH 2.1297288051315 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 9/223 200/9376 1.89201793721973 CLDN19/CLDN4/CLDN7/NCKAP1/ARPC1A/MYH10/TUBB3/CLDN6/GAPDH 1.99029852632226 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 5/223 86/9376 2.44446761914694 DSG2/DSP/JUP/PKP2/TCF7L1 2.10041696693094 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 13/223 333/9376 1.64139026919296 HLA-G/CCNE1/FN1/WNT7A/TCF7L1/HEY1/LAMA5/COL9A3/PARD3/LAMB1/PRKCZ/ATP6V1C2/COL1A2 1.86013539491296 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 12/223 300/9376 1.68179372197309 PGF/EFNA1/FLT4/FLT1/ERBB3/IGF2/RASGRF2/ERBB2/FGFR3/GNG12/DUSP9/MAPK8IP2 1.87336637221588 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 3/223 37/9376 3.40904132832384 PPARG/CDH1/TCF7L1 2.29166569414303 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 10/223 238/9376 1.76659004408938 PGF/EFNA1/FLT4/FLT1/IGF2/RASGRF2/PLA2G10/FGFR3/GNG12/RALBP1 1.86974514785877 Environmental Information Processing Signal transduction hsa04330 Notch signaling pathway 4/223 62/9376 2.71257051931144 DTX4/HEY1/JAG2/TLE6 2.11170150854553 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 5/223 89/9376 2.36206983423187 FN1/LAMA5/COL9A3/LAMB1/COL1A2 2.01517605370137 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 4/223 63/9376 2.66951384440174 HPGD/PTGDS/PTGES/PLA2G10 2.07525675692085 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 9/223 212/9376 1.78492258228276 PGF/EFNA1/FLT4/FLT1/FGFR3/CDH1/GNAI1/PARD3/PRKCZ 1.80429918394273 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 5/223 93/9376 2.26047543275954 CCNE1/FN1/LAMA5/LAMB1/NOS2 1.90672483421525 Metabolism Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism 3/223 41/9376 3.07645193043859 GLDC/PIPOX/GCSH 2.07975888084436 Human Diseases Cancer: specific types hsa05219 Bladder cancer 3/223 41/9376 3.07645193043859 ERBB2/FGFR3/CDH1 2.07975888084436 Metabolism Metabolism of cofactors and vitamins hsa00785 Lipoic acid metabolism 2/223 19/9376 4.42577295256077 GLDC/GCSH 2.33304653027121 NA NA hsa04081 Hormone signaling 9/223 219/9376 1.72787026230112 CGA/CSH1/DIO2/IGF2/LEP/CSH2/PTH1R/GNG12/GNAI1 1.70120153213926 Environmental Information Processing Membrane transport hsa02010 ABC transporters 3/223 45/9376 2.80298953662182 ABCG2/ABCA7/ABCA4 1.89230748441311 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 5/223 103/9376 2.04101179851104 COL21A1/ATP1A4/SLC6A19/COL9A3/COL1A2 1.65813723809317 Metabolism Amino acid metabolism hsa00220 Arginine biosynthesis 2/223 23/9376 3.65607330863716 GPT2/NOS2 1.99060388316921 Metabolism Lipid metabolism hsa00565 Ether lipid metabolism 3/223 51/9376 2.47322606172514 PLA2G10/GDPD3/GDPD1 1.64659351021537 Organismal Systems Endocrine system hsa04913 Ovarian steroidogenesis 3/223 52/9376 2.42566402207658 CGA/HSD3B1/CYP11A1 1.60906677689641 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 7/223 178/9376 1.65344888396231 NOTUM/SFRP1/WNT7A/SFRP2/TCF7L1/GPC4/TLE6 1.37382450180263 Cellular Processes Transport and catabolism hsa04146 Peroxisome 4/223 83/9376 2.02625749635313 PRDX1/PRDX5/PIPOX/NOS2 1.4657967641504 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 5/223 115/9376 1.82803665431858 GCM1/GATA3/PTH1R/MMP15/GNAI1 1.39452363264123 Human Diseases Cancer: specific types hsa05224 Breast cancer 6/223 148/9376 1.70452066416192 FLT4/ERBB2/WNT7A/TCF7L1/HEY1/JAG2 1.34842606605294 Human Diseases Cancer: specific types hsa05226 Gastric cancer 6/223 150/9376 1.68179372197309 JUP/CCNE1/ERBB2/WNT7A/CDH1/TCF7L1 1.313857428282 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 9/223 254/9376 1.48977790332262 FLT4/FLT1/ERBB3/ERBB2/FGFR3/MST1/PLCD4/MRLN/NOS2 1.23517175115899 Human Diseases Drug resistance: antineoplastic hsa01523 Antifolate resistance 2/223 30/9376 2.80298953662182 FOLR1/ABCG2 1.54382220774266 Human Diseases Endocrine and metabolic disease hsa04934 Cushing syndrome 6/223 155/9376 1.62754231158687 HSD3B1/CYP11A1/CCNE1/WNT7A/TCF7L1/GNAI1 1.22963492479902 Human Diseases Cancer: specific types hsa05213 Endometrial cancer 3/223 59/9376 2.13787337538953 ERBB2/CDH1/TCF7L1 1.3684792992266 Metabolism Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism 2/223 31/9376 2.71257051931144 GLDC/GCSH 1.49071971900096 NA NA hsa04981 Folate transport and metabolism 2/223 31/9376 2.71257051931144 FOLR1/ABCG2 1.49071971900096 Cellular Processes Cell motility hsa04814 Motor proteins 7/223 194/9376 1.51708196569738 TPM1/MYL6/MYH10/TUBB3/MYL10/MYO7B/KIF21A 1.1359205341788 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 8/223 232/9376 1.44982217411474 FN1/FGFR3/GNG12/NCKAP1/ARPC1A/MYH10/CFL1/MYL10 1.08286192260177 Human Diseases Cancer: specific types hsa05217 Basal cell carcinoma 3/223 63/9376 2.0021353833013 WNT7A/TCF7L1/GLI3 1.24568492349983 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 5/223 130/9376 1.61710934805105 GNG12/GNAI1/PRKCZ/COL1A2/NOS2 1.10589321963571 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 7/223 201/9376 1.46424826539946 MYCN/PPARG/JUP/HPGD/FLT1/ETV4/ASPSCR1 1.03848833000976 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 4/223 99/9376 1.69878153734656 KRT19/KRT18/CFD/KRT17 1.09096691294168 Metabolism Carbohydrate metabolism hsa00500 Starch and sucrose metabolism 2/223 36/9376 2.33582461385152 PGM1/PYGL 1.25338240076412 Metabolism Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis 3/223 67/9376 1.88260491265645 PGM1/ALDH3B2/GAPDH 1.13164071695156 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 4/223 101/9376 1.66514229898326 FN1/PLCD4/PRKCZ/COL1A2 1.0489979355088 Metabolism Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism 2/223 37/9376 2.27269421888256 RIMKLA/GPT2 1.21068478413221 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 5/223 138/9376 1.52336387859882 PTPRF/PPP1R3B/PYGL/PRKCZ/PRKAB2 0.966742136268224 Metabolism Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate 2/223 39/9376 2.1561457974014 GLDC/GCSH 1.12926941913871 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 5/223 140/9376 1.50160153747598 CDH1/GNG12/GNAI1/NOS2/PRKAB2 0.933334357654869 Human Diseases Cancer: specific types hsa05215 Prostate cancer 4/223 106/9376 1.58659785091801 CCNE1/FOLR1/ERBB2/TCF7L1 0.948003349186038 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 7/223 214/9376 1.37529860441725 HLA-G/AP1M2/WEE1/GNG12/TRIM5/GNAI1/CFL1 0.866852150542734 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 5/223 142/9376 1.48045222004674 GPC1/TXN/CDH5/PRKCZ/CAV1 0.900442075026914 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 5/223 144/9376 1.4598903836572 DLX5/WNT7A/FGFR3/LIFR/DUSP9 0.868048548510268 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 3/223 75/9376 1.68179372197309 CCNE1/PERP/PPP1R13L 0.925284199242039 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 3/223 75/9376 1.68179372197309 CGA/ATP1A4/GPX8 0.925284199242039 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 4/223 110/9376 1.5289033836119 NOG/ZFYVE9/LRRC32/THSD4 0.870929254169328 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 4/223 112/9376 1.50160153747598 LAMA5/GNAI1/LAMB1/NOS2 0.833537101965149 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 9/223 298/9376 1.26981069612062 CSH1/LEP/EBI3/CSH2/ACVRL1/CXCR6/LIFR/GDF15/XCR1 0.738802818891 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 3/223 78/9376 1.61710934805105 GNAI1/CFL1/NOS2 0.854222475868 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 3/223 79/9376 1.59663960946813 SLC6A2/ATP6V1C2/SLC6A11 0.831209600046294 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 3/223 80/9376 1.57668161434978 ERBB3/ERBB2/FGFR3 0.808517417344493 Metabolism Global and overview maps hsa01200 Carbon metabolism 4/223 116/9376 1.44982217411474 GLDC/GPT2/GAPDH/GCSH 0.760887939098842 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 6/223 193/9376 1.30709356630033 CXCR6/GNG12/XCR1/GNAI1/PARD3/PRKCZ 0.672842504687906 Metabolism Amino acid metabolism hsa00360 Phenylalanine metabolism 1/223 16/9376 2.62780269058296 ALDH3B2 1.01713867392485 Metabolism Glycan biosynthesis and metabolism hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/223 16/9376 2.62780269058296 A4GALT 1.01713867392485 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 4/223 122/9376 1.37851944424024 PPARG/LEP/PFKFB4/PRKAB2 0.656840162805265 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 2/223 50/9376 1.68179372197309 NOS2/CKMT1A 0.754478091088306 Metabolism Lipid metabolism hsa00120 Primary bile acid biosynthesis 1/223 17/9376 2.47322606172514 CYP8B1 0.948932822445369 Metabolism Metabolism of other amino acids hsa00430 Taurine and hypotaurine metabolism 1/223 17/9376 2.47322606172514 CDO1 0.948932822445369 NA NA hsa03273 Virion - Lassa virus and SFTS virus 1/223 17/9376 2.47322606172514 MYH10 0.948932822445369 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 4/223 125/9376 1.34543497757848 ACER2/SPTLC3/GNAI1/PRKCZ 0.606852737282048 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 2/223 52/9376 1.61710934805105 ANGPTL4/LIPG 0.696496603887656 Organismal Systems Digestive system hsa04980 Cobalamin transport and metabolism 1/223 18/9376 2.33582461385152 PRDX1 0.885422414906941 Organismal Systems Nervous system hsa04727 GABAergic synapse 3/223 89/9376 1.41724190053912 GNG12/GNAI1/SLC6A11 0.617307472374544 Organismal Systems Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/223 53/9376 1.58659785091801 PTH1R/ATP1A4 0.66843148590794 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 9/223 323/9376 1.17152813450138 EFNA1/ERBB3/CCNE1/ERBB2/TPM1/IGF2BP1/TRIM71/FGFR3/TIMP3 0.489662340258906 Metabolism Glycan biosynthesis and metabolism hsa00531 Glycosaminoglycan degradation 1/223 19/9376 2.21288647628039 HYAL4 0.826009377820445 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 2/223 54/9376 1.55721640923435 HLA-G/CGA 0.640947660176619 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 7/223 248/9376 1.18674960219876 TCF7L1/TXN/NCKAP1/ARPC1A/TUBB3/MYL10/GAPDH 0.465215363487185 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 2/223 55/9376 1.5289033836119 ACER2/SPTLC3 0.614020363892115 Metabolism Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis 2/223 56/9376 1.50160153747598 TUSC3/MGAT5B 0.587626340431709 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 4/223 134/9376 1.25506994177097 PLA2G10/MYL6/MYH10/CALD1 0.464178519123008 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/223 21/9376 2.0021353833013 DSEL 0.717580265419586 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 2/223 59/9376 1.42524891692635 PRDX6/GPX8 0.511431546267638 Organismal Systems Endocrine system hsa04923 Regulation of lipolysis in adipocytes 2/223 59/9376 1.42524891692635 CGA/GNAI1 0.511431546267638 Metabolism Amino acid metabolism hsa00340 Histidine metabolism 1/223 22/9376 1.91112922951488 ALDH3B2 0.667803937530684 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 3/223 98/9376 1.28708703212227 ASAP3/ARPC1A/CFL1 0.445918784871818 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 3/223 98/9376 1.28708703212227 HSD3B1/CYP11A1/ATP1A4 0.445918784871818 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 4/223 139/9376 1.20992354098784 KRT19/KRT18/KRT17/GNAI1 0.389187972465994 Metabolism Glycan biosynthesis and metabolism hsa00515 Mannose type O-glycan biosynthesis 1/223 23/9376 1.82803665431858 MGAT5B 0.620575107672291 Organismal Systems Excretory system hsa04964 Proximal tubule bicarbonate reclamation 1/223 23/9376 1.82803665431858 ATP1A4 0.620575107672291 Organismal Systems Endocrine system hsa04916 Melanogenesis 3/223 101/9376 1.24885672423745 WNT7A/TCF7L1/GNAI1 0.392472693980832 Metabolism Glycan biosynthesis and metabolism hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/223 24/9376 1.75186846038864 HS3ST3B1 0.575640812635402 Metabolism Amino acid metabolism hsa00310 Lysine degradation 2/223 63/9376 1.33475692220087 PLOD2/PIPOX 0.416113090078821 Organismal Systems Endocrine system hsa04927 Cortisol synthesis and secretion 2/223 65/9376 1.29368747844084 HSD3B1/CYP11A1 0.370851708410681 Organismal Systems Endocrine system hsa04929 GnRH secretion 2/223 65/9376 1.29368747844084 CGA/KISS1R 0.370851708410681 Metabolism Lipid metabolism hsa00592 alpha-Linolenic acid metabolism 1/223 26/9376 1.61710934805105 PLA2G10 0.491812239142891 Organismal Systems Digestive system hsa04977 Vitamin digestion and absorption 1/223 26/9376 1.61710934805105 SLC19A3 0.491812239142891 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 2/223 66/9376 1.27408615300992 HSD3B1/CYP11A1 0.348771156238246 Human Diseases Cancer: specific types hsa05221 Acute myeloid leukemia 2/223 68/9376 1.23661303086257 JUP/TCF7L1 0.305647794402042 Metabolism Glycan biosynthesis and metabolism hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/223 28/9376 1.50160153747598 A4GALT 0.414891809471026 Organismal Systems Excretory system hsa04966 Collecting duct acid secretion 1/223 28/9376 1.50160153747598 ATP6V1C2 0.414891809471026 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 2/223 70/9376 1.20128122998078 LEP/PRKAB2 0.263831782766865 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 2/223 70/9376 1.20128122998078 EPAS1/EGLN3 0.263831782766865 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 2/223 70/9376 1.20128122998078 HLA-G/CAV1 0.263831782766865 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 2/223 71/9376 1.18436177603739 ATP6V1C2/JAM3 0.243387465033138 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 2/223 71/9376 1.18436177603739 ERBB2/FGFR3 0.243387465033138 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 4/223 156/9376 1.0780728987007 CLDN19/CLDN4/CLDN7/CLDN6 0.153480597556932 Metabolism Lipid metabolism hsa00591 Linoleic acid metabolism 1/223 30/9376 1.40149476831091 PLA2G10 0.34378266042089 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 4/223 158/9376 1.06442640631208 GRB10/CASTOR1/WNT7A/ATP6V1C2 0.127476589923944 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 3/223 116/9376 1.08736663058605 SHANK2/GNG12/GNAI1 0.147783322650686 Metabolism Carbohydrate metabolism hsa00030 Pentose phosphate pathway 1/223 31/9376 1.35628525965572 PGM1 0.310131148568238 Metabolism Metabolism of other amino acids hsa00410 beta-Alanine metabolism 1/223 31/9376 1.35628525965572 ALDH3B2 0.310131148568238 Metabolism Global and overview maps hsa01230 Biosynthesis of amino acids 2/223 75/9376 1.12119581464873 GPT2/GAPDH 0.164478739968746 Metabolism Carbohydrate metabolism hsa00052 Galactose metabolism 1/223 32/9376 1.31390134529148 PGM1 0.2776246920251 Human Diseases Immune disease hsa05310 Asthma 1/223 32/9376 1.31390134529148 PRG2 0.2776246920251 Organismal Systems Digestive system hsa04971 Gastric acid secretion 2/223 76/9376 1.10644323814019 ATP1A4/GNAI1 0.145425222949915 Metabolism Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism 1/223 33/9376 1.27408615300992 GPT2 0.246182529296184 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 6/223 250/9376 1.00907623318386 CTSV/AP1M2/HYAL4/LAPTM4B/ROGDI/ATP6V1C2 0.0227034446936051 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 2/223 77/9376 1.09207384543707 ERBB2/RALBP1 0.126625116805751 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 3/223 122/9376 1.03388958318018 DIO2/ATP1A4/PLCD4 0.0588081792684459 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 3/223 122/9376 1.03388958318018 CSH1/CSH2/GNAI1 0.0588081792684459 Organismal Systems Environmental adaptation hsa04710 Circadian rhythm 1/223 34/9376 1.23661303086257 PRKAB2 0.21573197738509 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 4/223 168/9376 1.00106769165065 CSH1/LEP/CSH2/LIFR 0.00217958680793161 Metabolism Carbohydrate metabolism hsa00051 Fructose and mannose metabolism 1/223 35/9376 1.20128122998078 PFKFB4 0.186207406943217 Organismal Systems Immune system hsa04611 Platelet activation 3/223 126/9376 1.00106769165065 GNAI1/PRKCZ/COL1A2 0.00188328735875576 Metabolism Glycan biosynthesis and metabolism hsa00512 Mucin type O-glycan biosynthesis 1/223 36/9376 1.16791230692576 GALNT3 0.157549373016601 Organismal Systems Immune system hsa04612 Antigen processing and presentation 2/223 82/9376 1.02548397681286 HLA-G/HSPA2 0.0361767152830833 Metabolism Amino acid metabolism hsa00350 Tyrosine metabolism 1/223 37/9376 1.13634710944128 ALDH3B2 0.129703874121392 Metabolism Global and overview maps hsa01250 Biosynthesis of nucleotide sugars 1/223 37/9376 1.13634710944128 PGM1 0.129703874121392 Metabolism Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism 1/223 38/9376 1.10644323814019 PGM1 0.102621717760209 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 1/223 38/9376 1.10644323814019 QPRT 0.102621717760209 Organismal Systems Excretory system hsa04960 Aldosterone-regulated sodium reabsorption 1/223 38/9376 1.10644323814019 ATP1A4 0.102621717760209 Human Diseases Immune disease hsa05330 Allograft rejection 1/223 39/9376 1.0780728987007 HLA-G 0.0762579746986756 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 2/223 86/9376 0.977787047658776 ERBB3/ERBB2 -0.0323001093030315 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 2/223 87/9376 0.966548116076491 TPM1/ATP1A4 -0.0489273917267449 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 2/223 88/9376 0.95556461475744 SERPINE2/CFD -0.065368048691177 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 5/223 226/9376 0.930195642684233 CGA/ATP1A4/GLI3/GNAI1/HCAR1 -0.165799243258093 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 2/223 89/9376 0.94482793369275 GNAI1/TUBB3 -0.0816268182888693 Organismal Systems Aging hsa04211 Longevity regulating pathway 2/223 90/9376 0.934329845540608 PPARG/PRKAB2 -0.0977082626955047 Organismal Systems Digestive system hsa04976 Bile secretion 2/223 90/9376 0.934329845540608 ABCG2/ATP1A4 -0.0977082626955047 Human Diseases Substance dependence hsa05032 Morphine addiction 2/223 91/9376 0.924062484600601 GNG12/GNAI1 -0.113616776648403 Organismal Systems Digestive system hsa04975 Fat digestion and absorption 1/223 43/9376 0.977787047658776 PLA2G10 -0.0227869509886063 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 2/223 93/9376 0.904190173103814 GATA3/JAG2 -0.144931802363555 Metabolism Glycan biosynthesis and metabolism hsa00513 Various types of N-glycan biosynthesis 1/223 44/9376 0.95556461475744 TUSC3 -0.0461130938809681 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 1/223 44/9376 0.95556461475744 HLA-G -0.0461130938809681 Human Diseases Immune disease hsa05332 Graft-versus-host disease 1/223 45/9376 0.934329845540608 HLA-G -0.0689233754616833 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/223 95/9376 0.885154590512155 FLT1/ATP6V1C2 -0.175603996431672 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 2/223 97/9376 0.866903980398502 GNG12/GNAI1 -0.205663245928982 Human Diseases Endocrine and metabolic disease hsa04930 Type II diabetes mellitus 1/223 47/9376 0.894571128709093 PRKCZ -0.113096008598758 Organismal Systems Digestive system hsa04973 Carbohydrate digestion and absorption 1/223 48/9376 0.87593423019432 ATP1A4 -0.134503833738318 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 2/223 99/9376 0.84939076867328 ERBB2/JAG2 -0.235137420466136 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 2/223 99/9376 0.84939076867328 TPM1/PRKAB2 -0.235137420466136 Metabolism Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis 1/223 49/9376 0.858058021414844 GALNT3 -0.155487057514412 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/223 49/9376 0.858058021414844 GNAI1 -0.155487057514412 NA NA hsa04082 Neuroactive ligand signaling 4/223 199/9376 0.845122473353314 SLC6A2/GNG12/GNAI1/SLC6A11 -0.344683834226921 Organismal Systems Digestive system hsa04972 Pancreatic secretion 2/223 102/9376 0.824408687241713 PLA2G10/ATP1A4 -0.278308137139259 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 2/223 103/9376 0.816404719404415 GNAI1/NOS2 -0.292432969471745 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/223 51/9376 0.824408687241713 ATP6V1C2 -0.196254684565807 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 3/223 154/9376 0.819055384077806 TPM1/ATP1A4/GNAI1 -0.353386378267369 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 3/223 154/9376 0.819055384077806 MYL6/GNAI1/PRKAB2 -0.353386378267369 Cellular Processes Transport and catabolism hsa04145 Phagosome 3/223 155/9376 0.813771155793433 HLA-G/ATP6V1C2/TUBB3 -0.364905260750141 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 3/223 157/9376 0.803404644254663 PPARG/LEP/PRKAB2 -0.387737237126925 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 2/223 107/9376 0.785884916809857 PYGL/PRKAB2 -0.347679471051455 Metabolism Amino acid metabolism hsa00270 Cysteine and methionine metabolism 1/223 54/9376 0.778608204617173 CDO1 -0.254659681375688 Genetic Information Processing Replication and repair hsa03460 Fanconi anemia pathway 1/223 54/9376 0.778608204617173 FANCE -0.254659681375688 Cellular Processes Cell growth and death hsa04110 Cell cycle 3/223 158/9376 0.798319804734064 CCNE1/CDKN1C/WEE1 -0.399052267841209 Organismal Systems Immune system hsa04659 Th17 cell differentiation 2/223 109/9376 0.771465010079401 EBI3/GATA3 -0.374587006151069 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 1/223 56/9376 0.750800768737988 GLI3 -0.291936968618052 Organismal Systems Nervous system hsa04725 Cholinergic synapse 2/223 115/9376 0.731214661727432 GNG12/GNAI1 -0.45267018600405 Organismal Systems Nervous system hsa04726 Serotonergic synapse 2/223 115/9376 0.731214661727432 GNG12/GNAI1 -0.45267018600405 Organismal Systems Nervous system hsa04730 Long-term depression 1/223 60/9376 0.700747384155456 GNAI1 -0.362957002124381 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 3/223 170/9376 0.741967818517542 IGF2/WNT7A/TCF7L1 -0.529930831997555 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 1/223 62/9376 0.678142629827861 PRKAB2 -0.396869318060125 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 7/223 370/9376 0.795442976608896 CGA/CSH1/KISS1R/LEP/CSH2/PTH1R/NPFFR2 -0.62662198021577 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 3/223 174/9376 0.724911087057368 TUSC3/WFS1/CKAP4 -0.571693079978119 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 1/223 65/9376 0.646843739220421 LIPG -0.445945476944862 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 1/223 66/9376 0.63704307650496 GATA3 -0.461858085430023 Organismal Systems Endocrine system hsa04924 Renin secretion 1/223 69/9376 0.609345551439527 GNAI1 -0.508356991845944 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 2/223 128/9376 0.65695067264574 PDE6H/PGM1 -0.60994964788845 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/223 71/9376 0.592180888018695 CGA -0.538387414086663 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/223 73/9376 0.575956754100375 ALDH3B2 -0.56769675052136 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 1/223 73/9376 0.575956754100375 TRIM5 -0.56769675052136 Human Diseases Cancer: specific types hsa05218 Melanoma 1/223 73/9376 0.575956754100375 CDH1 -0.56769675052136 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 1/223 73/9376 0.575956754100375 ERBB2 -0.56769675052136 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 2/223 133/9376 0.632253278937253 PLK2/PRKAB2 -0.666690845298776 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 2/223 133/9376 0.632253278937253 GNG12/GNAI1 -0.666690845298776 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/223 75/9376 0.560597907324365 ERBB2 -0.596326719304547 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 2/223 138/9376 0.609345551439527 FN1/ARPC1A -0.721605237937203 Metabolism Carbohydrate metabolism hsa00562 Inositol phosphate metabolism 1/223 78/9376 0.539036449350351 PLCD4 -0.638080474334789 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/223 78/9376 0.539036449350351 NOS2 -0.638080474334789 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 3/223 196/9376 0.643543516061133 HLA-G/GNG12/TCF7L1 -0.787171845699701 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1/223 79/9376 0.532213203156042 ALDH3B2 -0.65169806050628 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 4/223 253/9376 0.664740601570393 SEPTIN3/ARPC1A/PLCD4/MYL10 -0.843779020709006 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 2/223 144/9376 0.58395615346288 TCF7L1/PRKAB2 -0.785287690147426 Organismal Systems Immune system hsa04623 Cytosolic DNA-sensing pathway 1/223 83/9376 0.506564374088281 GSDME -0.704770826374604 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 3/223 205/9376 0.615290386087717 PRKCZ/COL1A2/GAPDH -0.869276545543316 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 2/223 149/9376 0.564360309386944 GNG12/GNAI1 -0.836655467289343 Organismal Systems Endocrine system hsa04911 Insulin secretion 1/223 86/9376 0.488893523829388 ATP1A4 -0.743205801381021 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 1/223 87/9376 0.483274058038245 TCF7L1 -0.75577365494702 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 4/223 268/9376 0.627534970885483 GPR37/TXN/GNAI1/TUBB3 -0.965601045917209 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/223 90/9376 0.467164922770304 CD274 -0.792786161810113 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 2/223 157/9376 0.535603096169775 PPARG/CD24 -0.915911628424623 Cellular Processes Cell growth and death hsa04218 Cellular senescence 2/223 157/9376 0.535603096169775 HLA-G/CCNE1 -0.915911628424623 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 1/223 93/9376 0.452095086551907 CGA -0.828817347889824 Organismal Systems Digestive system hsa04970 Salivary secretion 1/223 93/9376 0.452095086551907 ATP1A4 -0.828817347889824 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 3/223 224/9376 0.563100576553491 HLA-G/CCNE1/MSX2 -1.03300830614388 Environmental Information Processing Signal transduction hsa04070 Phosphatidylinositol signaling system 1/223 98/9376 0.429029010707422 PLCD4 -0.886862384066073 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 1/223 99/9376 0.42469538433664 TRPV3 -0.898189587170044 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 2/223 166/9376 0.506564374088281 ATP1A4/GNAI1 -1.0011774741245 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 3/223 227/9376 0.555658718713577 HLA-G/GNG12/GNAI1 -1.05778917023868 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 1/223 100/9376 0.420448430493274 XCR1 -0.909427441877973 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 1/223 100/9376 0.420448430493274 CD24 -0.909427441877973 Cellular Processes Cell growth and death hsa04217 Necroptosis 2/223 168/9376 0.500533845825326 CHMP4C/PYGL -1.01961070875043 Metabolism Lipid metabolism hsa00564 Glycerophospholipid metabolism 1/223 104/9376 0.404277337012763 PLA2G10 -0.953521344035612 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 1/223 105/9376 0.400427076660261 PPP1R13L -0.96433895228924 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 1/223 105/9376 0.400427076660261 TPM1 -0.96433895228924 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 1/223 110/9376 0.382225845902976 GNAI1 -1.01727007227393 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 2/223 187/9376 0.449677465768207 CARD18/TXN -1.18647970091473 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/223 117/9376 0.359357632900234 MORF4L2 -1.08838584142432 Human Diseases Substance dependence hsa05034 Alcoholism 2/223 191/9376 0.440260136642171 GNG12/GNAI1 -1.21988721378844 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 2/223 205/9376 0.410193590725145 HLA-G/CCNE1 -1.3327061748726 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 2/223 205/9376 0.410193590725145 HLA-G/CCNE1 -1.3327061748726 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 1/223 133/9376 0.316126639468627 HLA-G -1.23979924958239 Human Diseases Infectious disease: viral hsa05162 Measles 1/223 136/9376 0.309153257715642 CCNE1 -1.26669343913302 Cellular Processes Cell growth and death hsa04210 Apoptosis 1/223 137/9376 0.30689666459363 CTSV -1.27556362884324 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 1/223 138/9376 0.304672775719763 ATP6V1C2 -1.28438769600568 Cellular Processes Cell growth and death hsa04114 Oocyte meiosis 1/223 138/9376 0.304672775719763 CCNE1 -1.28438769600568 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 2/223 216/9376 0.389304102308587 PPARG/HSPA2 -1.41729573409084 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 2/223 217/9376 0.387510074187349 KLF5/GNAI1 -1.42482368490524 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 1/223 142/9376 0.296090444009348 MID1 -1.31923582570987 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 1/223 142/9376 0.296090444009348 PPARG -1.31923582570987 Metabolism Global and overview maps hsa01240 Biosynthesis of cofactors 1/223 154/9376 0.273018461359269 QPRT -1.41980114577135 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 2/223 235/9376 0.357828451483637 PPARG/PRKAB2 -1.55612498369663 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 2/223 238/9376 0.353318008817877 RPS4Y1/CFD -1.57728439671653 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 3/223 308/9376 0.409527692038903 PPARG/GPX8/TUBB3 -1.64465752288779 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 1/223 163/9376 0.257943822388511 CCNE1 -1.49171683171301 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 4/223 388/9376 0.433451990199251 WNT7A/TUBB3/NOS2/GAPDH -1.77900589727205 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 1/223 180/9376 0.233582461385152 HLA-G -1.6205354815401 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 1/223 181/9376 0.23229195054877 NOS2 -1.6278555082894 Human Diseases Neurodegenerative disease hsa05020 Prion disease 2/223 275/9376 0.305780676722381 CAV1/TUBB3 -1.82378998346278 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 5/223 480/9376 0.43796711509716 WNT7A/GPR37/GPX8/TUBB3/NOS2 -1.97306456626597 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 3/223 368/9376 0.342756872684734 GPX8/TUBB3/NOS2 -2.00766899717356 Genetic Information Processing Translation hsa03010 Ribosome 1/223 222/9376 0.18939118490688 RPS4Y1 -1.90782569630438