category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	77/1439	222/9376	2.25992775263102	RPL3/RPL13A/RPL6/RPS2/RPL37A/RPLP0/RPS4X/RPL10/RPL10A/RPL5/RPL18A/MRPS34/RPL12/RPS9/MRPL42/MRPL22/MRPS33/MRPL3/RPL7/MRPL12/MRPL16/MRPS23/RPL27A/MRPL1/DAP3/MRPS11/MRPL21/MRPS7/MRPS10/RACK1/RPS27/MRPL11/RPS18/MRPL43/MRPL55/RPL23A/RPS17/MRPL2/RPL37/MRPL28/RPS8/RPL17/RPL9/RPL7A/MRPS5/RPS3/MRPS27/RPS3A/RPL34/MRPL10/MRPS9/RPS7/RPL13/MRPS35/RPS11/RPS27L/MRPL19/MRPS31/RPS23/MRPL44/RPS6/MRPL15/MRPS30/RPL29/MRPS24/MRPL39/MRPL51/RPL8/RPS16/RPS5/RPS14/RPL11/RPS20/RPL14/RPL15/RPL21/MRPL46	8.08918039276836
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	46/1439	142/9376	2.11069893999158	UBE2I/UBE2F/UBE2A/UBA3/SAE1/UBE2Q1/UBE2K/ANAPC5/ANAPC15/CDC16/CUL5/UBE2G2/ITCH/UBE3C/UBA1/SIAH1/UBE2G1/STUB1/FANCL/UBE2Q2/CUL2/CDC26/HUWE1/HERC1/KLHL9/UBA2/ANAPC1/UBE2O/MGRN1/HERC3/HERC4/UBE2D4/KEAP1/UBE2L3/UBE2R2/RNF7/PPIL2/UBE2J1/DDB1/SOCS1/TRIP12/MDM2/ANAPC7/RHOBTB1/VHL/SKP2	5.67849750750783
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	40/1439	117/9376	2.22756781478116	ACTG1/BRD7/RBBP4/ACTR6/ACTL6A/SMARCE1/SS18/SMARCC1/SMARCC2/BCL7C/EP400/INO80E/MBD2/BAZ1B/SMARCA4/BCL7B/RSF1/INO80D/SRCAP/GATAD2A/DPF2/INO80/CDK2AP1/KAT5/DPF3/HDAC1/SS18L1/PHF6/SMARCA5/BICRAL/SMARCD2/ZNHIT1/GATAD2B/RUVBL1/MTA1/TRRAP/MTA3/MRGBP/SMARCA1/BRD9	5.689108638989
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	92/1439	368/9376	1.62890896455872	ACTG1/NDUFB9/PSMC4/PSMD3/PSMC6/NUP214/NDUFS3/PSMD11/BAD/NDUFV1/NDUFS2/WIPI2/MTOR/MT-CO3/KLC1/NDUFB6/NDUFA6/NDUFV2/CHMP2B/NUP54/TNFRSF1B/POM121C/POM121/NDUFA5/CCS/TPR/NUP58/DCTN4/PSMD14/PSMD9/PPP3CB/NDUFA10/DCTN2/COX7A1/UBQLN1/SPG11/PFN2/ATF4/SDHA/WDR41/PINK1/PPP3CC/NDUFB8/ATG14/BECN1/PIK3C3/NDUFB1/ATP5PB/PSMD12/VAPB/NUP88/APAF1/SIGMAR1/UQCRC2/PSMC1/PSMB6/PSMD13/NDUFA9/TOMM40/GPX7/PSMC5/BID/PSMA6/ATP5MC1/DCTN5/NDUFA11/TP53/NDUFB10/VDAC1/EIF2S1/ATP5MC3/NDUFV3/RAE1/KIF5B/ATXN2/NUP50/SOD1/MCU/CASP3/NXF1/WIPI1/RB1CC1/ATP5F1A/GPX8/SETX/MAP1LC3A/NDUFS1/HDAC6/TRAF2/DNAH14/GPX3/ATG13	5.24065235086916
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	80/1439	308/9376	1.69237295019088	TGM2/NDUFB9/PSMC4/PSMD3/PSMC6/NDUFS3/PSMD11/NDUFV1/NDUFS2/WIPI2/MTOR/POLR2G/MT-CO3/KLC1/NDUFB6/NDUFA6/NDUFV2/NRF1/NDUFA5/HTT/DCTN4/VDAC2/PSMD14/PSMD9/NDUFA10/DCTN2/COX7A1/TFAM/SDHA/NDUFB8/ATG14/BECN1/PIK3C3/NDUFB1/ATP5PB/PSMD12/APAF1/REST/UQCRC2/PSMC1/PSMB6/PSMD13/NDUFA9/GPX7/PSMC5/POLR2B/PSMA6/ATP5MC1/DCTN5/NDUFA11/TP53/NDUFB10/VDAC1/HDAC1/ATP5MC3/MAPK9/NDUFV3/KIF5B/SOD1/MAP2K7/CASP3/EP300/WIPI1/RB1CC1/POLR2H/POLR2D/ATP5F1A/GPX8/HIP1/AP2M1/CASP8/POLR2C/AP2A1/NDUFS1/SP1/SLC25A4/TRAF2/DNAH14/GPX3/ATG13	5.26074849896734
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	52/1439	174/9376	1.9472015208518	RPN1/DNAJB12/MAN1B1/DNAJB11/UFD1/PRKCSH/ERLEC1/BAG1/DNAJA2/UBXN1/SAR1A/STT3B/UGGT2/SEC63/UBE2G2/UBQLN1/STT3A/RAD23B/ATF4/ERO1A/UBE2G1/STUB1/NPLOC4/TRAM1/SEC61A1/DNAJC10/PDIA4/DNAJC5/BAG2/OS9/SELENOS/MBTPS1/CAPN2/MOGS/PLAA/TXNDC5/UBXN6/UBE2D4/EIF2S1/MAPK9/CAPN1/MAP2K7/MBTPS2/HYOU1/UBXN4/UBE2J1/SEC62/ATXN3/PREB/SEC24A/TRAF2/DNAJB2	5.3698696223951
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	16/1439	30/9376	3.47500579105861	IDH3G/DLD/ACO2/IDH3B/CS/SUCLG1/SUCLG2/SDHA/IDH3A/PC/PDHA1/SUCLA2/ACLY/DLAT/DLST/FH	5.78111759400665
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	64/1439	235/9376	1.77447104224269	ACTG1/NDUFB9/NDUFS3/COA4/ACTL6A/SMARCE1/NDUFAF8/NDUFV1/NDUFS2/MTOR/ATP5ME/MT-CO3/SMARCC1/SMARCC2/NDUFB6/NDUFA6/NDUFV2/COA5/COX15/COX14/NDUFA5/COA1/COX11/NDUFAF2/NDUFA10/COX7A1/SOS2/COA6/ATF2/SMARCA4/SDHA/NDUFB8/PRKACB/NDUFB1/ATP5PB/UQCRC2/NDUFA9/ACSL5/SOS1/KDM3A/RPS6KB2/ATP5MC1/NDUFA11/NDUFAF6/DPF3/NDUFB10/ATP5MC3/NDUFV3/ADCY9/MGLL/PRKACA/NDUFAF4/RPS6/SMARCD2/CPT1A/ACSL4/ATP5F1A/ACSL3/TSC2/ZNF516/ADCY3/NDUFS1/KDM1A/NDUFAF7	5.11953015771042
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	36/1439	108/9376	2.17187861941163	EEF1A1/UBE2I/MAGOHB/NUP214/KPNA1/SUMO1/NUP54/IPO7/POM121C/THOC2/POM121/TPR/NUP58/TNPO2/UPF2/NUP42/NUP88/KPNA3/PNN/UPF3A/NMD3/IPO5/NCBP2/SNUPN/RAE1/NUP50/AAAS/CASC3/KPNA4/PHAX/TNPO3/NXF1/KPNB1/THOC5/IPO8/SENP2	5.21542063480752
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	70/1439	268/9376	1.7018451868524	NDUFB9/PSMC4/PSMD3/PSMC6/NDUFS3/PSMD11/NDUFV1/NDUFS2/MT-CO3/KLC1/NDUFB6/NDUFA6/NDUFV2/TRAP1/NDUFA5/MFN2/SLC39A1/VDAC2/PSMD14/PSMD9/UBE2G2/SLC39A3/NDUFA10/COX7A1/ATF4/UBA1/SDHA/UBE2G1/PINK1/NDUFB8/PRKACB/NDUFB1/ATP5PB/PSMD12/APAF1/UQCRC2/PSMC1/PSMB6/PSMD13/NDUFA9/TXN2/MFN1/PSMC5/PSMA6/ATP5MC1/NDUFA11/TP53/NDUFB10/VDAC1/SNCAIP/SLC39A9/EIF2S1/ATP5MC3/MAPK9/NDUFV3/KIF5B/PRKACA/SOD1/KEAP1/UBE2L3/MCU/SLC39A13/CASP3/GNAI3/ATP5F1A/UBE2J1/SLC39A7/NDUFS1/SLC25A4/UCHL1	4.96346606519883
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	49/1439	169/9376	1.88914885830479	BAD/WIPI2/MTOR/RRAGA/GORASP2/MTMR3/GABARAPL1/ATG12/RAF1/YKT6/LAMP1/AKT1/ATG9A/MAPK1/WDR41/VPS16/PRKACB/ATG14/BECN1/PIK3C3/AKT2/VPS39/NBR1/LAMP2/BNIP3/IRS1/RPS6KB2/RUBCN/CALCOCO2/EIF2S1/MAPK9/PRKACA/PLEKHM1/MAP2K2/ZFYVE1/ATG4A/WIPI1/RB1CC1/TAX1BP1/VPS11/TSC2/MAP1LC3A/IGF1R/RRAGB/PRKCD/DAPK2/PDPK1/IGBP1/ATG13	4.96645609950599
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	65/1439	250/9376	1.69406532314107	ARF3/PDCD6IP/WASHC3/SPG21/RABEP1/EHD4/USP8/CHMP2B/SNF8/CHMP4A/SNX1/VTA1/WASHC5/IST1/MVB12A/TGFBR2/ITCH/ARPC4/CYTH4/STAM/PIP5K1C/LDLR/ARAP2/SNX4/CHMP4B/VPS4B/BIN1/ARFGEF2/PSD4/RAB5B/SH3GLB2/VPS28/IGF2R/ARF5/CHMP3/IL2RB/RAB35/SH3GL1/SMAD3/RAB11FIP2/PIP5K1A/RNF41/KIF5B/ARAP1/SNX3/RAB4A/VPS37C/ACAP1/GRK6/AP2M1/ARFGAP3/AP2A1/IL2RA/MDM2/IGF1R/WASL/RUFY1/CHMP6/ZFYVE27/EHD1/PDGFRA/CHMP7/RUFY2/EPN2/EEA1	4.73606837688163
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	108/1439	480/9376	1.46601806810285	NDUFB9/PSMC4/PSMD3/PSMC6/NDUFS3/PSMD11/BAD/NDUFV1/NDUFS2/WIPI2/MTOR/MT-CO3/KLC1/NDUFB6/PPID/NDUFA6/NDUFV2/CHMP2B/TRAP1/TNFRSF1B/NDUFA5/CCS/HTT/MFN2/HSD17B10/DCTN4/VDAC2/RAF1/PSMD14/PSMD9/PPP3CB/UBE2G2/NDUFA10/DCTN2/COX7A1/SPG11/ATF4/MAPK1/UBA1/SDHA/WDR41/UBE2G1/PINK1/PPP3CC/NDUFB8/ATG14/BECN1/PIK3C3/NDUFB1/ATP5PB/PSMD12/VAPB/APAF1/CASP7/SIGMAR1/DVL3/UQCRC2/PSMC1/PSMB6/PSMD13/NDUFA9/TOMM40/GPX7/MFN1/PSMC5/BID/PSMA6/ATP5MC1/DCTN5/NDUFA11/CAPN2/FAS/NDUFB10/VDAC1/SNCAIP/EIF2S1/ATP5MC3/MAPK9/NDUFV3/PRNP/KIF5B/ATXN2/CAPN1/SOD1/MAP2K2/MAP2K7/UBE2L3/MCU/CASP3/ZFYVE1/GSK3B/WIPI1/RB1CC1/ATP5F1A/GPX8/HIP1/UBE2J1/CASP8/MAP1LC3A/NDUFS1/ATXN3/SLC25A4/TRAF2/DNAH14/CSNK2A2/GPX3/ATG13/UCHL1	4.46286584209851
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	35/1439	116/9376	1.96592461239846	IDH3G/ME2/DLD/TKT/TALDO1/ACO2/IDH3B/SDSL/CS/SUCLG1/SUCLG2/SDHA/IDH3A/PFKL/GOT2/PC/ALDH6A1/PGAM1/G6PD/PDHA1/ACOX1/ECHS1/PKM/ACSS1/SUCLA2/GCSH/PSPH/PGLS/DLAT/PGK1/DLST/FH/ADH5/MMUT/HK1	4.45712258378614
Genetic Information Processing	Transcription	hsa03040	Spliceosome	60/1439	243/9376	1.60879897734195	SNRPF/LSM6/TXNL4A/MAGOHB/RBM17/CDC40/SMNDC1/CCDC12/WBP11/SRSF4/PHF5A/CWC15/CDC5L/SNRPB2/ZMAT2/DHX15/RBMX2/SYF2/USP39/THOC2/SF3B2/SF1/PQBP1/SRSF1/TCERG1/PRPF31/PRPF38A/ISY1/SRSF6/SNRPE/PPIE/DDX42/SF3B3/CWC25/SLU7/SF3A1/SNRNP200/SNIP1/EFTUD2/BUD31/RBMX/SF3B5/PRPF6/SRSF9/NCBP2/CHERP/SF3B1/CASC3/PRPF4/DHX16/DDX5/CTNNBL1/GPKOW/SF3A3/SRSF8/DHX8/THOC5/HNRNPM/DDX23/SNRPD2	4.09409736947098
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	87/1439	388/9376	1.46098020532586	NDUFB9/PSMC4/PSMD3/PSMC6/NDUFS3/PSMD11/BAD/NDUFV1/NDUFS2/WIPI2/MTOR/MT-CO3/KLC1/NDUFB6/PPID/NDUFA6/NDUFV2/NDUFA5/NAE1/SLC39A1/HSD17B10/VDAC2/RAF1/PSMD14/PSMD9/PPP3CB/SLC39A3/NDUFA10/COX7A1/AKT1/ATF4/MAPK1/SDHA/PPP3CC/NDUFB8/ATG14/BECN1/PIK3C3/NDUFB1/AKT2/ATP5PB/PSMD12/APAF1/CASP7/DVL3/UQCRC2/PSMC1/PSMB6/PSMD13/IKBKG/NDUFA9/IRS1/PSMC5/BID/PSMA6/ATP5MC1/NDUFA11/CAPN2/FAS/NDUFB10/VDAC1/SLC39A9/BACE1/EIF2S1/ATP5MC3/MAPK9/NDUFV3/KIF5B/CAPN1/MAP2K2/MAP2K7/MCU/SLC39A13/CASP3/GSK3B/WIPI1/RB1CC1/ATP5F1A/CASP8/SLC39A7/NDUFS1/SLC25A4/TRAF2/BACE2/CSNK2A2/ATG13/IDE	3.9487028477817
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	35/1439	122/9376	1.86923979539525	ACTG1/MED14/BAD/MTOR/NOTCH2/RAF1/AKT1/MAPK1/PRKACB/PFKL/AKT2/RXRA/TP53/HDAC1/RCAN1/NCOR1/MED1/MED17/PRKACA/MAP2K2/PLCD1/PLCG2/GSK3B/EP300/MED27/SLC2A1/RXRB/FOXO1/TSC2/MDM2/SLC9A1/BMP4/HDAC3/PLCE1/PDPK1	4.11474203917844
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	25/1439	77/9376	2.1154661877386	BAD/POLK/RAF1/TGFBR2/SOS2/AKT1/MAPK1/SMAD4/CRK/AKT2/CDKN1B/IKBKG/SOS1/TP53/HDAC1/SMAD3/CTBP2/CDK4/MAP2K2/STAT5A/ABL1/MDM2/SHC1/CTBP1/BCR	4.18476904120048
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	56/1439	227/9376	1.60738153330905	NDUFB9/NDUFS3/BAD/NDUFV1/NDUFS2/MT-CO3/NDUFB6/NDUFA6/NDUFV2/ACP1/CBR1/NDUFA5/EPHX1/VDAC2/RAF1/NDUFA10/COX7A1/SOS2/AKT1/GSTM3/MAPK1/SDHA/NDUFB8/NDUFB1/AKT2/ATP5PB/UQCRC2/IKBKG/NDUFA9/PRKD2/VEGFA/SOS1/ATP5MC1/NDUFA11/PRKD3/NDUFB10/VDAC1/ATP5MC3/MAPK9/NDUFV3/SOD1/KEAP1/MAP2K2/MAP2K7/GSTA4/GSTO1/ARNT/ATP5F1A/NCF2/ABL1/NDUFS1/SLC25A4/PRKCD/PDPK1/GSTT2B/GSTM4	3.94435089473457
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1439	48/9376	2.44336344683808	DLD/HSD17B10/ALDH7A1/HMGCL/BCKDHB/HADHA/ALDH6A1/HADHB/MCCC1/ACAA2/AUH/ECHS1/IVD/ACAA1/BCKDHA/HMGCS1/ALDH9A1/MMUT	4.26864361608515
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	61/1439	253/9376	1.57096358637284	ACTG1/BCL10/WIPI2/MTOR/SEPTIN6/RRAGA/RBCK1/PPID/ATG12/ARPC4/CYTH4/CAPNS1/SEPTIN9/UBE2V1/PFN2/AKT1/MAPK1/ATG14/BECN1/CRK/PIK3C3/AKT2/TRADD/ACTN1/IKBKG/ROCK2/TNIP1/RIPK1/BNIP3/ACTN4/RPS6KB2/FNBP1/CAPN2/ROCK1/CALCOCO2/TP53/VDAC1/UBE2D4/MAPK9/CAPN1/ITGA5/ILK/ARHGEF2/PLCD1/PLCG2/GSK3B/WIPI1/BCAR1/FNBP1L/MYD88/FOXO1/MDM2/MAP1LC3A/WASL/RRAGB/PRKCD/TRAF2/SEPTIN2/PLCE1/DOCK1/HK1	3.92001455761455
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	31/1439	105/9376	1.9236639200503	FUNDC1/USP8/GABARAPL1/MFN2/CCZ1B/ATF4/ATG9A/SIAH1/PINK1/TFE3/RHOT2/BECN1/NBR1/BCL2L13/TOMM40/HUWE1/BNIP3/MFN1/RAB5B/SAMM50/TOMM70/CALCOCO2/TP53/EIF2S1/MAPK9/TAX1BP1/MAP1LC3A/SP1/TRAF2/CSNK2A2/USP15	4.05259480761273
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	10/1439	19/9376	3.42928203064994	DLD/BCKDHB/PDHA1/DHTKD1/BCKDHA/GCSH/DLAT/LIAS/DLST/LIPT1	4.51309284904973
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/1439	23/9376	3.11617367132973	FDPS/ZMPSTE24/ICMT/FNTA/GGPS1/RCE1/PCYOX1/DHDDS/HMGCS1/NUS1/MVD	4.32640929123113
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/1439	63/9376	2.17187861941163	KMT5A/DLD/KMT2A/NSD3/COLGALT1/PLOD1/SETD2/ALDH7A1/PLOD3/HADHA/SMYD2/KMT5B/NSD1/ECHS1/GCDH/DHTKD1/KMT2B/ALDH9A1/PRDM2/DLST/KMT5C	3.97370798475432
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/1439	43/9376	2.42442264492461	ALDH7A1/HADHA/HADHB/ACSL5/ACAA2/ACOX1/ACADVL/ECHS1/ECI2/GCDH/ACAA1/CPT1A/ALDH9A1/ACSL4/ACSL3/ADH5	3.9861194532612
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	13/1439	32/9376	2.64697706740792	DLD/SUCLG1/SUCLG2/BCKDHB/HADHA/ALDH6A1/ACOX1/ECHS1/ACSS1/SUCLA2/BCKDHA/MMUT/ACACA	3.97359839313298
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1439	70/9376	2.04777126973096	BAD/PAK2/RAF1/PRCC/SOS2/FLCN/AKT1/EPAS1/MAPK1/TFE3/CRK/AKT2/CUL2/VEGFA/SOS1/EGLN1/MAP2K2/EP300/SLC2A1/ARNT/FH/VHL	3.74646626787284
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1439	75/9376	1.9981283298587	BAD/REV3L/TOP2B/AKT1/GSTM3/MAPK1/AKT2/APAF1/BID/FAS/TP53/CASP3/MLH1/GSTA4/GSTO1/POLH/CASP8/MDM2/MSH2/MSH6/PDPK1/GSTT2B/GSTM4	3.69521776259455
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/1439	33/9376	2.56676564112283	IDH3G/DLD/ACO2/IDH3B/CS/IDH3A/BCKDHB/GOT2/PDHA1/DHTKD1/BCKDHA/DLAT/DLST	3.83889010203201
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	36/1439	138/9376	1.69973109345258	BAD/MTOR/EIF4E2/RAF1/SOS2/AKT1/MAPK1/PRKACB/CRK/AKT2/MKNK2/IRS1/SOS1/RPS6KB2/INPP5A/INPPL1/MAPK9/PRKAR1A/PRKACA/MAP2K2/RPS6/SREBF1/GSK3B/PPP1CB/SOCS2/ELK1/FOXO1/SOCS1/TSC2/PYGB/EXOC7/SHC1/PDPK1/ACACA/TRIP10/HK1	3.52589668079476
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	39/1439	157/9376	1.61853374822395	NDUFB9/NDUFS3/NDUFV1/NDUFS2/MT-CO3/NDUFB6/NDUFA6/NDUFV2/NDUFA5/NDUFA10/ITCH/COX7A1/AKT1/ATF4/SDHA/NDUFB8/NDUFB1/AKT2/MLX/CASP7/UQCRC2/NDUFA9/IRS1/RXRA/BID/MLXIP/LEPR/NDUFA11/FAS/NDUFB10/EIF2S1/MAPK9/NDUFV3/SREBF1/CASP3/GSK3B/CASP8/NDUFS1/TRAF2	3.32781491718123
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1439	57/9376	2.05756921838996	FADS1/HSD17B12/HADHA/HADHB/ACSL5/CBR4/ACAA2/ACOX1/ACADVL/ECHS1/SCP2/ACAA1/HSD17B4/CPT1A/ACSL4/ACSL3/SCD5/ACACA	3.40996105319755
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	36/1439	144/9376	1.62890896455872	RORA/PSMC4/PSMD3/PSMC6/PSMD11/WIPI2/MTOR/NOP56/VDAC2/PSMD14/PSMD9/AKT1/ATG14/BECN1/PIK3C3/AKT2/PSMD12/PSMC1/PSMB6/PSMD13/PSMC5/PSMA6/KAT5/VDAC1/MAPK9/ATXN2/MCU/WIPI1/RB1CC1/SP1/ATXN3/RBPJ/SLC25A4/TRAF2/DAB1/ATG13	3.23823959265667
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	24/1439	87/9376	1.79741678847859	APPL1/BAD/MTOR/POLK/RAF1/TGFBR2/SOS2/AKT1/MAPK1/RALB/SMAD4/AKT2/SOS1/RPS6KB2/TP53/AREG/MAPK9/SMAD3/MAP2K2/CASP3/GSK3B/MLH1/MSH2/MSH6	3.18162041577877
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	60/1439	275/9376	1.42159327816034	NDUFB9/PSMC4/PSMD3/PSMC6/NDUFS3/PSMD11/BAD/NDUFV1/NDUFS2/MT-CO3/KLC1/NDUFB6/NDUFA6/NDUFV2/NDUFA5/VDAC2/PSMD14/PSMD9/PPP3CB/NDUFA10/COX7A1/ATF2/ATF4/MAPK1/SDHA/PPP3CC/NDUFB8/PRKACB/NDUFB1/ATP5PB/PSMD12/APAF1/UQCRC2/PSMC1/PSMB6/PSMD13/NDUFA9/PSMC5/PSMA6/ATP5MC1/NDUFA11/NDUFB10/VDAC1/EIF2S1/ATP5MC3/MAPK9/NDUFV3/PRNP/KIF5B/PRKACA/SOD1/MCU/CASP3/GSK3B/ATP5F1A/NCF2/NDUFS1/SLC25A4/PRKCD/CSNK2A2	3.02136582577274
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/1439	137/9376	1.61701911810209	ACTG1/BAD/CTSW/RAF1/PRF1/BCL2A1/AKT1/ATF4/MAPK1/AKT2/TRADD/APAF1/CASP7/GZMB/IKBKG/RIPK1/BID/CAPN2/FAS/TP53/EIF2S1/MAPK9/CAPN1/MAP2K2/CASP3/PARP3/NTRK1/CASP2/CTSF/CASP8/DFFA/TRAF2/ENDOG/PDPK1	3.09766369449133
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	47/1439	205/9376	1.49382870896117	COL3A1/COL1A2/NDUFB9/NDUFS3/NDUFV1/NDUFS2/MTOR/MT-CO3/NDUFB6/NDUFA6/NDUFV2/PTPA/NDUFA5/VDAC2/TGFBR2/NDUFA10/COX7A1/AKT1/SDHA/NDUFB8/NDUFB1/AKT2/ATP5PB/UQCRC2/NDUFA9/IRS1/ATP5MC1/NDUFA11/G6PD/PDHA1/NDUFB10/VDAC1/ATP5MC3/MAPK9/NDUFV3/SMAD3/COL1A1/GSK3B/PPP1CB/SLC2A1/ATP5F1A/NCF2/NDUFS1/SP1/GSR/SLC25A4/PRKCD	3.04391669809461
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	51/1439	227/9376	1.46386532497788	CCR1/MTOR/GNB2/GNG10/PTK2B/TAPBP/RAF1/PPP3CB/TAP1/SOS2/ATF2/AKT1/ATF4/MAPK1/PPP3CC/PRKACB/ARHGEF1/CRK/ARHGEF12/AKT2/TRADD/IKBKG/ROCK2/RIPK1/GNB5/VEGFA/BID/SOS1/RPS6KB2/GNG11/ROCK1/FAS/TP53/GNA12/ADCY9/PRKACA/CDK4/MAP2K2/CASP3/GNAI3/GSK3B/ELK1/BCAR1/GNA11/CASP8/TSC2/MDM2/ADCY3/SP1/TRAF2/PDGFRA	3.01235304215594
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	15/1439	46/9376	2.12466386681572	PSMC4/PSMD3/PSMC6/PSMD11/PSMD14/PSMD9/PSMB10/PSMB8/PSMD12/PSMC1/PSMB6/PSMD13/PSMC5/PSMA6/PSME3	3.25573224883426
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	52/1439	238/9376	1.42358430516056	CFD/RPL3/RPL13A/RPL6/RPS2/RPL37A/RPLP0/RPS4X/RPL10/RPL10A/RPL5/RPL18A/RPL12/RPS9/RPL7/RPL27A/RPS27/RPS18/RPL23A/RPS17/RPL37/MAPK1/RPS8/RPL17/RPL9/RPL7A/RPS3/IKBKG/RPS3A/RPL34/MAVS/TYK2/RPS7/RPL13/RPS11/RPS27L/RPS23/MAPK9/RPS6/PLCG2/RPL29/MYD88/RPL8/RPS16/RPS5/IKBKE/RPS14/RPL11/RPS20/RPL14/RPL15/RPL21	2.81832197373497
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/1439	44/9376	2.07315686398383	APEX1/POLD2/PNKP/MPG/APTX/RFC1/PARG/XRCC1/NTHL1/TDG/PARP3/SMUG1/POLL/POLD1	3.03801578386675
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	37/1439	158/9376	1.52581346047273	PPP2R5E/ANAPC5/ANAPC15/CDC16/PDS5B/SMC3/MAD2L2/TFDP2/SMAD4/CDKN1B/CDC26/PPP2R5A/ANAPC1/TP53/HDAC8/HDAC1/ATR/SMAD3/YWHAG/RBL2/CDK4/PRKDC/PPP2R1B/CDC7/GSK3B/EP300/NIPBL/CDC14B/ZBTB17/ATRX/ABL1/MDM2/ESCO1/ANAPC7/CDK7/MAU2/SKP2	2.83811334751386
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/1439	23/9376	2.54959664017887	SSBP1/POLD2/RFC1/RPA1/MLH1/MSH2/MSH6/POLD1/PMS2	3.16807140763533
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	20/1439	73/9376	1.7851057145849	BAD/POLK/RAF1/SOS2/AKT1/MAPK1/AKT2/RASSF1/RXRA/SOS1/TP53/JAK3/KIF5B/CDK4/MAP2K2/PLCG2/STAT5A/EML4/RXRB/PDPK1	2.86725225577917
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	22/1439	83/9376	1.72703601061648	RBBP4/DCAF7/PHC2/MAX/L3MBTL2/MBD6/ASXL2/LCOR/PHC3/HCFC1/BMI1/UBE2D4/HDAC1/USP7/EP300/AEBP2/AUTS2/E2F6/OGT/KDM2A/FOXK1/RYBP	2.8327278016832
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	26/1439	103/9376	1.64472361470007	MAGOHB/NUDT21/PPP2R5E/WDR33/RNMT/CPSF2/UPF2/FIP1L1/PNN/UPF3A/SMG1/CPSF7/PPP2R5A/PAPOLA/NCBP2/PPP2R3A/GSPT1/CASC3/PPP2R1B/NXF1/PPP1CB/HBS1L/CSTF3/CPSF3/SMG5/CPSF4	2.80136633423179
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1439	32/9376	2.23974982626824	WIPI2/MTOR/GABARAPL1/ATG12/ATG9A/BECN1/PIK3C3/ATG4A/WIPI1/IGBP1/ATG13	2.99109684951444
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	25/1439	99/9376	1.64536259046335	BAD/MTOR/NOTCH2/RAF1/SOS2/AKT1/MAPK1/PRKACB/AKT2/CDKN1B/SOS1/RPS6KB2/TP53/NCOR1/MAPK9/ADCY9/MED1/PRKACA/CDK4/MAP2K2/MDM2/ADCY3/SP1/IGF1R/SHC1	2.74856145126531
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/1439	47/9376	1.94082770245294	ME2/DLD/ALDH7A1/ACYP2/PC/PDHA1/ACYP1/PKM/ACSS1/ALDH9A1/DLAT/FH/ADH5/ACACA	2.75314651551618
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	22/1439	86/9376	1.66679056838567	BAD/MTOR/PAK2/RAF1/SOS2/AKT1/MAPK1/CRK/AKT2/CDKN1B/SOS1/RPS6KB2/AREG/MAPK9/MAP2K2/MAP2K7/PLCG2/GSK3B/ELK1/STAT5A/ABL1/SHC1	2.64495727944761
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	38/1439	170/9376	1.45643625066427	ACTG1/BRD7/ACTL6A/BAD/SMARCE1/MTOR/SMARCC1/SMARCC2/POLK/RAF1/TGFBR2/SOS2/SMARCA4/AKT1/GSTM3/MAPK1/SMAD4/AKT2/DVL3/SOS1/RPS6KB2/TXNRD2/DPF3/TP53/SMAD3/KEAP1/CDK4/MAP2K2/SMARCD2/PLCG2/GSK3B/GSTA4/GSTO1/ELK1/IGF1R/SHC1/GSTT2B/GSTM4	2.55715439016929
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1439	21/9376	2.48214699361329	B3GAT3/B4GALT7/CHST3/CHST12/B3GALT6/CHPF2/CHST13/XYLT1	2.89512202893334
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	44/1439	203/9376	1.41225604809032	ACTG1/COL1A2/BAD/COL6A1/PARVB/PAK2/ARHGAP35/RAF1/LAMB2/SOS2/PIP5K1C/AKT1/MAPK1/CRK/AKT2/ZYX/COL6A3/ACTN1/ROCK2/VEGFA/ACTN4/SOS1/ITGB5/CAPN2/ROCK1/MAPK9/PIP5K1A/COL1A1/ITGA5/ILK/GSK3B/PPP1CB/LAMA4/ELK1/PPP1R12C/BCAR1/PPP1R12A/ARHGAP5/IGF1R/SHC1/COL6A2/PDGFRA/PDPK1/DOCK1	2.52840827482497
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/1439	34/9376	2.10799983648776	POLR2G/POLR1D/POLR1A/POLR2B/POLR3D/POLR2H/POLR2D/POLR3A/POLR2C/POLR1C/POLR2M	2.75579601860987
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	21/1439	83/9376	1.64853437377027	PEX14/PEX19/ECH1/HMGCL/ACSL5/ACOT8/PHYH/ACOX1/FAR1/ECI2/SCP2/SOD1/ACAA1/ABCD3/HSD17B4/NUDT12/PEX13/ACSL4/ACSL3/SLC25A17/CRAT	2.52686431497183
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	47/1439	224/9376	1.36712002382607	LTBR/FDPS/ANAPC5/ANAPC15/CRTC3/CDC16/VDAC2/PPP3CB/TGFBR2/ATF2/AKT1/ATF4/MAPK1/PPP3CC/PRKACB/SMAD4/AKT2/CRTC1/IL15RA/CDC26/VAC14/IKBKG/NFYB/ANAPC1/KAT5/TP53/JAK3/VDAC1/IL2RB/ATR/MAPK9/ADCY9/SMAD3/RANBP3/PRKACA/CDK4/MAP2K2/EP300/ELK1/SLC2A1/STAT5A/TRRAP/IL2RA/ADCY3/ANAPC7/SLC25A4/ELK4	2.36789216946081
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/1439	75/9376	1.65062775075284	IDH3G/TKT/TALDO1/ACO2/IDH3B/SDSL/CS/IDH3A/PFKL/GOT2/PC/PYCR2/MTR/PGAM1/ALDH18A1/PKM/MAT2A/PSPH/PGK1	2.4087195498791
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/1439	138/9376	1.46365733047305	NDUFB9/NDUFS3/NDUFV1/NDUFS2/ATP6V1C1/ATP5ME/MT-CO3/NDUFB6/NDUFA6/NDUFV2/COX15/NDUFA5/COX11/NDUFA10/COX7A1/SDHA/NDUFB8/LHPP/NDUFB1/ATP5PB/UQCRC2/NDUFA9/ATP5MC1/NDUFA11/ATP6V0A2/NDUFB10/ATP6V1D/ATP5MC3/NDUFV3/ATP5F1A/NDUFS1	2.33633728419115
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/1439	70/9376	1.67544922068897	APPL1/MTOR/TNFRSF1B/AKT1/AKT2/TRADD/IKBKG/IRS1/RXRA/ACSL5/LEPR/MAPK9/CPT1A/SLC2A1/ACSL4/RXRB/ACSL3/TRAF2	2.41517189302394
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	43/1439	205/9376	1.36669435075171	PSMC4/PSMD3/PSMC6/PSMD11/NCOR2/POLK/TAPBP/PSMD14/TAP1/AKT1/AKT2/CDKN1B/PSMD12/TRADD/APAF1/PSMC1/PSMD13/IKBKG/RIPK1/PSMC5/BID/MAVS/TYK2/FAS/TP53/JAK3/HDAC1/MAPK9/CDK4/MAP2K7/VIM/USP7/PLCG2/CASP3/MYD88/CASP8/CD247/MDM2/RUNX3/RBPJ/IKBKE/TRAF2/SKP2	2.26027170372117
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1439	51/9376	1.7886059218684	ACTG1/ATP6V1C1/ERO1A/PRKACB/SEC61A1/PDIA4/ATP6V0A2/ATP6V1D/ADCY9/PRKACA/PLCG2/ADCY3/SLC12A2/TJP2	2.40441011777899
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	34/1439	158/9376	1.40209885556953	ATP6V1C1/MTOR/RRAGA/EIF4E2/TBC1D7/LAMTOR3/RAF1/SOS2/FNIP1/FLCN/AKT1/MAPK1/AKT2/DVL3/RICTOR/IRS1/SOS1/RPS6KB2/CLIP1/PRR5L/NPRL2/ATP6V1D/MAP2K2/RPS6/GSK3B/MAPKAP1/WDR59/TSC2/NPRL3/IGF1R/RRAGB/PDPK1/EIF4B/SKP2	2.17035548687923
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	44/1439	214/9376	1.33966344748755	BAD/MTOR/TNFRSF1B/PAK2/GNB2/GNG10/PTK2B/TAPBP/RAF1/CUL5/PPP3CB/TAP1/AKT1/MAPK1/AP1M1/PPP3CC/CRK/AKT2/TRADD/IKBKG/DCAF1/RIPK1/GNB5/BID/RPS6KB2/GNG11/AP1G1/FAS/APOBEC3G/ATR/MAPK9/MAP2K2/MAP2K7/PLCG2/CASP3/GNAI3/RNF7/APOBEC3C/MYD88/GNA11/DDB1/CASP8/CD247/TRAF2	2.14017063677818
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	19/1439	78/9376	1.58714206803157	MTMR3/SACM1L/PI4KA/IP6K2/PIP5K1C/PI4KB/PIKFYVE/PIK3C3/ALDH6A1/INPP5A/INPPL1/INPP4A/PIP5K1A/PLCD1/PLCG2/IPPK/INPP5F/PLCE1/PIP4K2B	2.21709127880561
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1439	110/9376	1.48082633141702	LTBR/MTOR/EIF4E2/AKT1/EPAS1/MAPK1/PFKL/AKT2/CDKN1B/CUL2/MKNK2/VEGFA/RPS6KB2/PDHA1/EGLN1/MAP2K2/RPS6/PLCG2/EP300/SLC2A1/ARNT/PGK1/IGF1R/VHL/HK1	2.15986338672022
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1439	63/9376	1.65476466240886	POLR2G/RAD23B/POLD2/CETN2/GTF2H3/RFC1/POLR2B/RPA1/POLR2H/UVSSA/POLR2D/DDB1/POLR2C/CDK7/POLD1/POLR2M	2.22023298663421
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	42/1439	204/9376	1.3414544414013	ACTG1/COL1A2/MTOR/RAF1/SOS2/AKT1/MAPK1/SDC2/PRKACB/ARHGEF1/ARHGEF12/AKT2/ROCK2/VEGFA/NUDT16L1/SOS1/RPS6KB2/ITGB5/ROCK1/FAS/TP53/HSPB2/PRKACA/COL1A1/MAP2K2/RPS6/ITGA5/PLCG2/CASP3/PPP1CB/DDX5/ELK1/PPP1R12C/PPP1R12A/MDM2/SLC9A1/MSN/IGF1R/HOXD10/PLCE1/PDPK1/EIF4B	2.09944098791745
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	27/1439	122/9376	1.4419849850192	MTOR/RAF1/SOS2/ATF2/AKT1/ATF4/MAPK1/PRKACB/CRK/AKT2/IRS1/SOS1/MAPK9/ADCY9/PRKACA/MAP2K2/PLCG2/GNAI3/GSK3B/EP300/SOCS2/STAT5A/BCAR1/GNA11/SOCS1/ADCY3/SHC1	2.09223531662764
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	12/1439	44/9376	1.77699159770042	DCTN4/DCTN2/DYNC1LI2/NSF/PRKACB/DYNC1I2/DYNLL2/RAB5B/DCTN5/ADCY9/PRKACA/ADCY3	2.19959711107183
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1439	59/9376	1.65651759107667	BAD/POLK/RAF1/SOS2/AKT1/MAPK1/AKT2/SOS1/TP53/MAP2K2/ILK/GSK3B/MLH1/ELK1/PDPK1	2.15388330688349
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1439	49/9376	1.72863808483783	COLGALT1/C1GALT1C1/GALNT15/PLOD3/GALNT11/GALNT6/RFNG/POFUT1/FUT11/GXYLT2/OGT/POFUT2/XXYLT1	2.17734257189263
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1439	80/9376	1.54746351633079	BAD/MTOR/EIF4E2/RAF1/SOS2/AKT1/MAPK1/AKT2/NF1/VEGFA/SOS1/RPS6KB2/MAP2K2/RPS6/PLCG2/GSK3B/IGF1R/SHC1/PDGFRA	2.09382298765272
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/1439	248/9376	1.28736353650609	ACTG1/KPNA1/KLC1/DCTN4/RAF1/RHOH/STX10/DCTN2/ARPC4/CYTH4/CYFIP1/DYNC1LI2/PFN2/AKT1/MAPK1/VPS16/PIK3C3/AKT2/VPS39/TRADD/KPNA3/CASP7/ACBD3/DYNC1I2/DYNLL2/RPS3/IKBKG/ROCK2/RIPK1/TXN2/GCC2/RAB5B/PKN1/DCTN5/MAPK9/KIF5B/PLEKHM1/MAP2K2/MAP2K7/KPNA4/CASP3/NCKAP1/EXOC5/MYD88/VPS11/CASP8/EXOC7/WASL/TRAF2	1.9527989346934
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/1439	50/9376	1.69406532314107	SAT2/CNDP2/ALDH7A1/OAT/GOT2/P4HA1/PYCR2/ALDH18A1/P4HA3/ALDH9A1/GAMT/P4HA2/L3HYPDH	2.09520001423639
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	34/1439	163/9376	1.35908968822077	BAD/PTK2B/RAF1/TGFBR2/STAT6/SOS2/ATF2/AKT1/ATF4/MAPK1/SMAD4/AKT2/APAF1/STAT4/IKBKG/BID/SOS1/MAVS/TYK2/FAS/TP53/JAK3/MAPK9/SMAD3/MAP2K2/MAP2K7/CASP3/EP300/ELK1/STAT5A/MYD88/DDB1/CASP8/IKBKE	1.96917378516389
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	37/1439	180/9376	1.33932514863717	BAD/MTOR/SRSF4/SRSF1/TAPBP/TAP1/SRSF6/AKT1/HCFC1/AKT2/TRADD/APAF1/HCFC2/IKBKG/BID/MAVS/TYK2/SRSF9/FAS/TP53/EIF2S1/TNFSF14/ITGA5/CASP3/NXF1/EIF2B2/PPP1CB/EIF2B3/MYD88/CASP8/EIF2B4/SRSF8/TSC2/IKBKE/TRAF2/RNASEL/EIF2B1	1.95722459360138
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1439	71/9376	1.56008182521117	MTOR/RAF1/AKT1/MAPK1/PFKL/AKT2/SLC1A5/PGAM1/TP53/G6PD/PDHA1/PKM/MAP2K2/SLC2A1/NTRK1/PDGFRA/HK1	2.01702049252067
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/1439	77/9376	1.52313565517179	BAD/MTOR/RALBP1/POLK/RAF1/TGFBR2/AKT1/MAPK1/RALB/SMAD4/AKT2/IKBKG/VEGFA/RPS6KB2/TP53/MAPK9/SMAD3/CDK4	1.96258920097725
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/1439	62/9376	1.57636351408909	MTOR/EIF4EBP2/AKT1/PRKACB/AKT2/IRS1/RPS6KB2/HDAC1/ADCY9/PRKACA/SOD1/FOXO1/ADCY3/IGF1R/CLPB	1.93870644271479
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1439	18/9376	2.17187861941163	HCFC1/MTRR/LMBRD1/MTR/MMUT/ZNF76	2.11892316010227
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1439	68/9376	1.53309079017291	BAD/MTOR/FCGR1A/RAF1/CSF1R/BCL2A1/SOS2/PIM1/AKT1/MAPK1/AKT2/IKBKG/SOS1/RPS6KB2/MAP2K2/STAT5A	1.87851770940919
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	20/1439	90/9376	1.44791907960775	APPL1/MTOR/EIF4E2/SESN3/ATF2/AKT1/ATF4/PRKACB/AKT2/IRS1/RPS6KB2/TP53/ADCY9/PRKACA/RB1CC1/FOXO1/TSC2/ADCY3/IGF1R/ATG13	1.81800185559708
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	29/1439	140/9376	1.34966742777723	MTOR/NRF1/GNB2/GNG10/MEF2D/RAF1/TFAM/AKT1/MAPK1/PRKACB/SMAD4/BECN1/PIK3C3/AKT2/GNB5/RPS6KB2/GNG11/ADCY9/SMAD3/PRKACA/MAP2K2/RPS6/GNAI3/SLC9A1/ADCY3/MAP1LC3A/PIK3R6/SPHK2/HDAC4	1.77486399561553
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/1439	157/9376	1.32802769085042	RBBP4/HIPK1/MTOR/HIPK2/PPID/VDAC2/RAF1/PPP3CB/TGFBR2/AKT1/MAPKAPK2/MAPK1/PPP3CC/AKT2/RAD50/CAPN2/TP53/VDAC1/ATR/SMAD3/CAPN1/RBL2/CDK4/MAP2K2/MCU/PPP1CB/LIN37/FOXO1/TSC2/MDM2/SLC25A4/KIR2DL4	1.7648437874166
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1439	130/9376	1.35324744747955	COL3A1/COL1A2/GNB2/GNG10/RAF1/TGFBR2/SOS2/ATF2/AKT1/ATF4/MAPK1/PRKACB/AKT2/GNB5/VEGFA/SOS1/GNG11/MAPK9/ADCY9/PRKACA/COL1A1/MAP2K2/MAP2K7/GNAI3/RXFP1/ADCY3/SHC1	1.72687781016917
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1439	59/9376	1.54608308500489	NME4/NME1/CMPK1/NME3/DCTD/HDDC2/DCTPP1/NT5E/ASMTL/UMPS/NME2/CTPS1/NT5C3B/NME6	1.79157307732538
Human Diseases	Infectious disease: viral	hsa05162	Measles	28/1439	136/9376	1.3414544414013	CD46/BAD/RACK1/AKT1/AKT2/CDKN1B/TRADD/APAF1/IKBKG/BID/MAVS/TYK2/FAS/TP53/JAK3/IL2RB/EIF2S1/MAPK9/CDK4/CASP3/GSK3B/STAT5A/MYD88/CASP8/IL2RA/MSN/IKBKE/CSNK2A2	1.70786712842828
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	40/1439	205/9376	1.27134358209461	HDAC7/BAD/LTBR/ATF2/ATF4/MAPKAPK2/MAPK1/UBR4/PRKACB/CDKN1B/TRADD/GTF2H3/PSMC1/ACTN1/VAC14/IKBKG/ACTN4/TP53/JAK3/HDAC8/HDAC1/YWHAG/PRKACA/RBL2/CDK4/PKM/USP7/CASP3/EP300/STAT5A/DDB1/CASP8/DNAJA3/MDM2/RBPJ/HDAC6/HDAC4/TRAF2/HDAC3/SKP2	1.67253795794108
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/1439	120/9376	1.35742413713227	BAD/RAF1/MAGED1/SOS2/AKT1/ATF4/MAPKAPK2/MAPK1/CRK/AKT2/IRS1/SOS1/TP53/MAPK9/MAP2K2/MAP2K7/PLCG2/GSK3B/NTRK1/ABL1/KIDINS220/SH2B1/PRKCD/SHC1/PDPK1	1.67784049695917
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1439	71/9376	1.4683123060811	RAF1/SOS2/AKT1/MAPK1/AKT2/SOS1/MAPK9/MAP2K2/GSK3B/SOCS2/TNFRSF11A/STAT5A/SOCS1/SOCS5/CGA/SHC1	1.68653128122672
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/1439	99/9376	1.38210457598922	SLC44A1/MTOR/DGKZ/RAF1/SOS2/PIP5K1C/AKT1/MAPK1/AKT2/CHKB/SOS1/RPS6KB2/MAPK9/PIP5K1A/MAP2K2/PCYT1A/GPCPD1/TSC2/SP1/PDGFRA/PDPK1	1.62736099587365
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	27/1439	133/9376	1.32272306896498	HOMER3/GABARAPL1/ATG12/PRMT1/RAF1/TGFBR2/SOS2/AKT1/MAPK1/SMAD4/AKT2/CDKN1B/BNIP3/IRS1/SOS1/MAPK9/SMAD3/RBL2/MAP2K2/USP7/EP300/FOXO1/MDM2/IGF1R/PLK2/PDPK1/SKP2	1.59601584936452
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	31/1439	156/9376	1.29477379234155	BAD/RAF1/SOS2/LDLR/AKT1/MAPK1/AKT2/TRADD/APAF1/IKBKG/RIPK1/RXRA/BID/SOS1/MAVS/SCARB1/TYK2/FAS/TP53/EIF2S1/YWHAG/CDK4/MAP2K2/PPP2R1B/CASP3/GSK3B/PSME3/CASP8/IKBKE/TRAF2/RNASEL	1.58078771603907
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/1439	56/9376	1.5125583242331	EEF1A1/SEC22B/SAR1A/RAB1B/APAF1/BCL2L13/CASP7/BNIP3/EEF1G/CASP3/MYD88/HBS1L/CASP8	1.63801243140476
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1439	78/9376	1.42007448192299	LSM6/EXOSC6/LSM1/CNOT9/XRN2/MPHOSPH6/CNOT8/PFKL/MTREX/TOB1/EXOSC10/DDX6/EDC4/TENT4B/EXOSC7/CNOT2/DCPS	1.58623188667544
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1439	101/9376	1.35473616854389	COL3A1/COL1A2/TGFBR2/PIM1/AKT1/MAPK1/SMAD4/AKT2/CDKN1B/VEGFA/MAPK9/SMAD3/COL1A1/CDK4/PLCD1/PLCG2/CASP3/STAT5A/FOXO1/PRKCD/PLCE1	1.52614937696784
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1439	85/9376	1.37978171115562	NME4/NME1/CMPK1/NME3/DCTD/HDDC2/ITPA/IMPDH1/DCTPP1/GMPR2/NTPCR/NT5E/ASMTL/NME2/IMPDH2/CTPS1/NT5C3B/NME6	1.49761480513037
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	30/1439	154/9376	1.26927971264316	NME4/PPCS/NME1/DLD/CMPK1/COASY/NME3/COX15/PANK2/UROD/UROS/RDH11/COQ4/GMPPA/PNPO/PPCDC/RFK/QPRT/GPHN/MAT2A/UMPS/NME2/LIAS/CTPS1/COQ5/GGCX/UGP2/HMBS/NME6/LIPT1	1.43462793015549
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1439	196/9376	1.2299924834423	CCR1/MTOR/GNB2/GNG10/RAF1/PPP3CB/AKT1/MAPKAPK2/MAPK1/PPP3CC/ATG14/BECN1/PIK3C3/AKT2/TRADD/IKBKG/GNB5/VEGFA/BID/GNG11/TYK2/FAS/TP53/RCAN1/MAPK9/CDK4/MAP2K2/MAP2K7/PLCG2/CASP3/GSK3B/EP300/CASP8/MAP1LC3A/IKBKE/PIK3R6/TRAF2	1.38550527256634
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1439	75/9376	1.39000231642344	SESN3/SIAH1/APAF1/CCNG1/TP53I3/BID/PPM1D/FAS/TP53/ATR/CDK4/ZNF385A/CASP3/CASP8/TSC2/MDM2	1.44384589034252
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	43/1439	232/9376	1.20763940475905	TMSB4X/ACTG1/PAK2/ITGAE/ARHGAP35/RAF1/ITGAD/ARPC4/CYFIP1/SOS2/PIP5K1C/PFN2/AKT1/MAPK1/ABI2/SSH1/ARHGEF1/CRK/PIKFYVE/ARHGEF12/AKT2/ACTN1/ROCK2/ACTN4/SOS1/ITGB5/ROCK1/GNA12/PIP5K1A/MAP2K2/ITGA5/NCKAP1/PPP1CB/PPP1R12C/BCAR1/PPP1R12A/SLC9A1/MSN/WASL/FGD3/PDGFRA/DOCK1/PIP4K2B	1.36355764916114
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/1439	32/9376	1.62890896455872	GLB1/PFKL/GANC/PGM1/GALK1/UGP2/GALE/HK1	1.51734453408664
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1439	17/9376	1.91636348771614	PAPSS1/KYAT3/TXNRD2/MTR/SEPSECS	1.61014637481407
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	20/1439	98/9376	1.32972160372141	DGKZ/MTMR3/SACM1L/PI4KA/IP6K2/PIP5K1C/PI4KB/PIKFYVE/PIK3C3/INPP5A/PIP4P2/INPPL1/INPP4A/PIP5K1A/PLCD1/PLCG2/IPPK/INPP5F/PLCE1/PIP4K2B	1.39707944275035
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1439	27/9376	1.68923892620904	FADS1/HSD17B12/ACOX1/SCP2/ACAA1/HSD17B4/SCD5	1.52706296423317
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1439	76/9376	1.37171281225998	MTOR/POLK/RAF1/SOS2/AKT1/MAPK1/AKT2/SOS1/TP53/CDK4/MAP2K2/PLCG2/MDM2/IGF1R/SHC1/PDGFRA	1.38535379126296
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	24/1439	122/9376	1.28176443112817	BCL10/PPP2R5E/PAK2/RAF1/PPP3CB/SOS2/AKT1/MAPK1/PPP3CC/AKT2/IKBKG/SOS1/PPP2R5A/PPP2R3A/MAPK9/CARD11/ITK/CDK4/MAP2K2/MAP2K7/PPP2R1B/GSK3B/CD247/PDPK1	1.3337952956711
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1439	82/9376	1.35080255597553	NME4/NME1/CMPK1/NME3/TPMT/ITPA/IMPDH1/GSTM3/GSTA4/GSTO1/UMPS/NME2/CES2/IMPDH2/GSTT2B/GSTM4/NME6	1.3584891875588
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1439	38/9376	1.54317691379247	GMPPA/PGM1/GNPNAT1/GALK1/UGP2/GALE/GNPDA2/HK1/GNE	1.42854528374454
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1439	60/9376	1.41172110261756	BAD/RAF1/PPP3CB/AKT1/MAPKAPK2/MAPK1/PPP3CC/AKT2/VEGFA/SH2D2A/MAP2K2/PLCG2/SPHK2	1.36223444482076
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1439	33/9376	1.57954808684482	SEC22B/USE1/YKT6/GOSR1/BET1L/STX16/STX2/VAMP4	1.42000906571179
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/1439	106/9376	1.29083351908427	ZEB1/BAD/MTOR/RAF1/SOS2/AKT1/ATF4/MAPK1/AKT2/CDKN1B/IKBKG/SOS1/TP53/MAP2K2/GSK3B/EP300/FOXO1/MDM2/IGF1R/PDGFRA/PDPK1	1.2821692847975
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1439	18/9376	1.80989884950969	ACSL5/CBR4/ACSL4/ACSL3/ACACA	1.464412270298
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1439	78/9376	1.33654068886869	ACTG1/CD2AP/SEPTIN6/ARPC4/SEPTIN9/MAD2L2/CRK/ITGA5/ILK/SEPTIN1/ARHGAP10/BCAR1/WASL/SHC1/SEPTIN2/DOCK1	1.27080219061035
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	45/1439	250/9376	1.17281445448228	CTBS/ATP6V1C1/MTOR/RRAGA/GLB1/SNAPIN/GNS/FUCA1/GNPTAB/TMEM175/PLA2G15/HGSNAT/LAMTOR3/CTSW/AP3D1/LAMP1/DTNBP1/SPG11/TFE3/AP1M1/VPS16/PIKFYVE/VPS39/LAMP2/AP1G1/GALC/ATP6V0A2/IGF2R/ATP6V1D/PLEKHM1/ABCA5/BLOC1S4/CTSF/VPS11/SLC11A1/LIPA/AP2M1/AP2A1/OSBPL2/AP5M1/RRAGB/IDUA/GALNS/OSBPL5/ARSG	1.17922772634359
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1439	56/9376	1.39620768390748	RPN1/DPM3/MAN1B1/ALG13/STT3B/STT3A/MGAT2/ALG8/MOGS/DOLK/MGAT3/DPM1	1.2661839267357
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/1439	125/9376	1.2510020847811	PPP2R5E/RAF1/AKT1/CERS5/MAPK1/AKT2/TRADD/DEGS1/CERS4/CERS2/ROCK2/BID/PPP2R5A/ROCK1/TP53/GNA12/PPP2R3A/MAPK9/MAP2K2/PPP2R1B/GNAI3/SPHK2/TRAF2/PDPK1	1.2028897929329
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1439	73/9376	1.33882928593868	PDCD6IP/NELFE/CHMP4A/CCNT1/CHMP4B/VPS4B/CPSF7/NELFA/APOBEC3G/MAP1A/TNPO3/EP300/FURIN/APOBEC3C/CHMP6	1.23742448486108
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1439	149/9376	1.22441479215152	NDUFB9/NDUFS3/NDUFV1/NDUFS2/NDUFB6/NDUFA6/NDUFV2/NDUFA5/GNB2/GNG10/NDUFA10/MAPK1/NDUFB8/PRKACB/NDUFB1/NDUFA9/GNB5/GNG11/NDUFA11/NDUFB10/MAPK9/NDUFV3/ADCY9/MGLL/PRKACA/GNAI3/ADCY3/NDUFS1	1.17571537800039
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1439	19/9376	1.71464101532497	GLB1/GNS/HGSNAT/IDUA/GALNS	1.32765204501095
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1439	41/9376	1.43026152985644	RAF1/MAPK1/RASSF1/VEGFA/TP53/CDK4/MAP2K2/MDM2/DAPK2	1.17558795945947
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1439	93/9376	1.26109081127127	MMP14/PTK2B/RAF1/SOS2/ATF4/MAPK1/PRKACB/SOS1/MAPK9/ADCY9/PRKACA/MAP2K2/MAP2K7/ELK1/GNA11/ADCY3/PRKCD/CGA	1.07739940598651
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1439	36/9376	1.44791907960775	GANC/GYG1/PGM1/PGM2L1/PYGB/GBE1/UGP2/HK1	1.14647666421692
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1439	59/9376	1.32521407286133	GSTM3/GGCT/GPX7/LANCL1/G6PD/GSTA4/GSTO1/GPX8/GSR/GSTT2B/GSTM4/GPX3	1.06695261820916
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1439	42/9376	1.39620768390748	DLD/ALDH7A1/KYAT3/HADHA/ECHS1/GCDH/DHTKD1/ALDH9A1/DLST	1.09572478597987
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1439	31/9376	1.47127261314981	DERA/TKT/TALDO1/PFKL/PGM1/G6PD/PGLS	1.11905450935972
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1439	31/9376	1.47127261314981	CNDP2/ALDH7A1/HADHA/ALDH6A1/ACOX1/ECHS1/ALDH9A1	1.11905450935972
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/1439	31/9376	1.47127261314981	SEC63/SRP72/SEC61A1/SPCS1/SGTA/SRPRA/SEC62	1.11905450935972
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1439	15/9376	1.7375028955293	GLB1/SLC33A1/ST6GALNAC6/ST6GALNAC4	1.21712751851607
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1439	48/9376	1.35742413713227	PDCD6IP/CHMP4A/IST1/LAMP1/LDLR/CHMP4B/VPS4B/LAMP2/SCARB1/CHMP7	1.05705618674681
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1439	54/9376	1.32725915630711	CISD1/MTAP/ADI1/APIP/SDSL/KYAT3/GOT2/MTR/MAT2A/DNMT3A/BHMT2	1.02688540670021
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1439	54/9376	1.32725915630711	REV3L/POLK/FANCL/RPA1/ATR/MLH1/WDR48/POLH/FANCI/POLI/PMS2	1.02688540670021
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1439	37/9376	1.40878613151025	GMPPA/PGM1/GNPNAT1/GALK1/UGP2/GALE/HK1/GNE	1.06080283773943
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1439	37/9376	1.40878613151025	POLK/TPR/MAPK1/RXRA/TP53/MAP2K2/NTRK1/RXRB	1.06080283773943
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1439	107/9376	1.21787586135232	PPP4R3B/PRMT1/PPP3CB/ATF2/AKT1/ATF4/PPP3CC/PRKACB/PFKL/AKT2/PGAM1/PDHA1/PRKACA/PKM/EP300/CPT1A/SLC2A1/FOXO1/PYGB/ACACA	0.965100209382472
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	14/1439	72/9376	1.26692919465678	OTUD5/ATG12/SIKE1/TRADD/IKBKG/RIPK1/MAVS/MAPK9/DHX58/RNF125/CASP8/IKBKE/TRIM25/TRAF2	0.96808907377573
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1439	21/9376	1.55134187100831	PPCS/AASDHPPT/COASY/PANK2/PPCDC	1.07695255808476
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1439	32/9376	1.42529534398888	BECN1/APAF1/CASP7/BID/MAPK9/CASP3/CASP8	1.02609376227738
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1439	138/9376	1.18036881489762	ACTG1/PTK2B/ARPC4/PIP5K1C/AKT1/MAPK1/ARHGEF1/CRK/ARHGEF12/AKT2/IKBKG/ROCK2/PKN1/ROCK1/MAPK9/PIP5K1A/MAP2K2/ITGA5/MAP2K7/GSK3B/BCAR1/MYD88/WASL/TRAF2/DOCK1	0.908866008266813
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1439	126/9376	1.18936210110637	COL3A1/ACTG1/COL1A2/ARHGAP35/APBB1IP/AKT1/MAPK1/PRKACB/ARHGEF1/ARHGEF12/AKT2/ROCK2/ROCK1/ADCY9/PRKACA/COL1A1/PLCG2/GNAI3/PPP1CB/PPP1R12A/STIM1/ADCY3/PIK3R6	0.911161403644044
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/1439	67/9376	1.26422785309035	DLD/ALDH7A1/PFKL/PGM1/PGAM1/PDHA1/PKM/ACSS1/ALDH9A1/DLAT/PGK1/ADH5/HK1	0.924170980403114
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/1439	157/9376	1.16202422949412	VPS8/PLA2G15/PROS1/ADAM9/RAB14/MAPKAPK2/MAPK1/VPS16/CRK/VPS39/EPOR/CASP7/TMEM30A/RXRA/RAB5B/ITGB5/PANX1/MAP2K2/CASP3/CPT1A/SLC2A1/ARNT/BCAR1/VPS11/LIPA/DNMT3A/SPHK2/DOCK1	0.871717427551104
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1439	44/9376	1.33274369827532	GTF2F2/GTF2F1/TAF12/GTF2H3/TAF11/GTF2I/TAF7/TAF1/CDK7	0.941969101879448
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1439	109/9376	1.19552951527246	MTOR/PTPA/AKT1/AKT2/MLX/IRS1/MLXIP/RPS6KB2/MAPK9/SLC27A3/SREBF1/GSK3B/PPP1CB/CPT1A/SLC2A1/OGT/FOXO1/PYGB/PRKCD/PDPK1	0.874266497240948
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	35/1439	201/9376	1.1345634579016	ZEB1/SS18/KMT2A/POLK/MAX/FCGR1A/CSF1R/PRCC/TGFBR2/BCL2A1/TFE3/ATF1/CDKN1B/CCNT1/ASPSCR1/HOXA9/GZMB/RXRA/AFF1/TP53/BMI1/IL2RB/HDAC1/SS18L1/NCOR1/DDX5/NTRK1/RXRB/ZBTB17/FOXO1/MDM2/SP1/IGF1R/ELK4/HOXA11	0.82112632563295
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	22/1439	122/9376	1.17495072853416	MTOR/PPP2R5E/ELAVL1/RAB14/EEF2/AKT1/PFKL/AKT2/IRS1/LEPR/RPS6KB2/PPP2R5A/PPP2R3A/SREBF1/PPP2R1B/CPT1A/FOXO1/TSC2/IGF1R/SCD5/PDPK1/ACACA	0.828168615033397
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1439	110/9376	1.18466106513362	BMPR2/TGFBR2/SMAD7/MAPK1/SMAD4/ACVR1/RPS6KB2/ROCK1/HDAC1/HAMP/NCOR1/SMAD3/THSD4/PPP2R1B/EP300/SMAD5/NBL1/SP1/BMP4/NEO1	0.829494242462645
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	19/1439	104/9376	1.19035655102368	DGKZ/CEPT1/PLA2G15/LPGAT1/CRLS1/LPCAT1/PLAAT3/PEMT/AGPAT2/PISD/GPAT4/CHKB/MBOAT1/PCYT1A/SELENOI/MBOAT2/GPCPD1/PLA2G12A/AGPAT5	0.831161906565015
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1439	39/9376	1.33654068886869	DLD/ALDH7A1/ATIC/MTR/MTHFR/MAT2A/GCSH/BHMT2	0.896714202803336
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	56/1439	333/9376	1.09572254673019	COL1A2/BAD/ATP6V1C1/MTOR/COL6A1/PPP2R5E/NOTCH2/RAF1/LAMB2/SOS2/NFX1/AKT1/MAPK1/UBR4/PRKACB/AKT2/CDKN1B/COL6A3/TRADD/DVL3/PSMC1/IKBKG/VEGFA/SOS1/RPS6KB2/ITGB5/PPP2R5A/ATP6V0A2/TYK2/FAS/TP53/PPP2R3A/TADA3/HDAC1/ATP6V1D/ATR/PRKACA/RBL2/COL1A1/CDK4/PKM/MAP2K2/RFNG/ITGA5/PPP2R1B/CASP3/GSK3B/EP300/LAMA4/FOXO1/CASP8/TSC2/MDM2/RBPJ/IKBKE/COL6A2	0.757299972392201
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1439	28/9376	1.39620768390748	HSD17B12/HADHA/HADHB/ACAA2/ECHS1/THEM4	0.893985351474479
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1439	93/9376	1.19103021064509	ACTG1/ACP1/CCM2/TGFBR2/MAPK1/SMAD4/ACTN1/ROCK2/ACTN4/ROCK1/SMAD3/AFDN/EP300/IGF1R/FER/WASL/CSNK2A2	0.788292144301681
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1439	93/9376	1.19103021064509	POLK/MAX/LAMB2/AKT1/AKT2/CDKN1B/APAF1/IKBKG/RXRA/TP53/CDK4/CASP3/LAMA4/RXRB/ZBTB17/TRAF2/SKP2	0.788292144301681
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	30/1439	173/9376	1.12987905056096	ACTG1/KPNA1/FDPS/RAF1/AKT1/MAPK1/AKT2/TRADD/APAF1/IKBKG/BID/MAVS/TYK2/FAS/CALCOCO2/VDAC1/EIF2S1/RAE1/CDK4/MAP2K2/CASP3/NXF1/EP300/MYD88/CASP8/IKBKE/SLC25A4/TRIM25/CPSF4/RNASEL	0.734150824319482
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1439	23/9376	1.41644257787715	RXYLT1/B3GALNT2/FKTN/B4GAT1/POMGNT2	0.851395640443734
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1439	12/9376	1.62890896455872	COQ4/COQ5/GGCX	0.928187148133173
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	50/1439	300/9376	1.08593930970581	DUSP3/PAK2/MAX/LAMTOR3/MAP3K13/RAF1/CSF1R/PPP3CB/TGFBR2/TAOK1/SOS2/ATF2/AKT1/ATF4/MAPKAPK2/MAPK1/PPP3CC/PRKACB/CRK/AKT2/PPM1A/TRADD/MKNK2/NF1/PPM1B/IKBKG/VEGFA/SOS1/MAPK8IP3/FAS/TP53/MAP3K20/AREG/GNA12/MAPK9/PRKACA/MAP2K2/MAP2K7/CASP3/PPP5C/MAPKAPK5/ELK1/NTRK1/MYD88/IGF1R/ELK4/TRAF2/PDGFRA/MAP4K4/TAOK2	0.644159015903641
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1439	238/9376	1.09506485012351	BAD/RALBP1/PAK2/GNB2/GNG10/RAF1/PLAAT3/CSF1R/SOS2/AKT1/MAPK1/RGL2/PRKACB/RALB/AKT2/RASSF1/NF1/IKBKG/GNB5/VEGFA/RAB5B/SOS1/GNG11/RALGAPA1/MAPK9/KSR1/PRKACA/MAP2K2/PLCG2/RASAL3/AFDN/ELK1/NTRK1/ABL1/IGF1R/PLA2G12A/RALGAPA2/SHC1/PLCE1/PDGFRA	0.632514832983135
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1439	47/9376	1.24767495157689	MTOR/MAPK1/IRS1/MAPK9/PKM/SOCS2/SOCS1/PRKCD/HK1	0.724771845191991
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1439	59/9376	1.21477956678955	PLAAT3/AKT1/PRKACB/AKT2/IRS1/ADCY9/MGLL/PRKACA/GNAI3/ADCY3/CGA	0.704642388651043
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1439	24/9376	1.35742413713227	B3GAT3/B4GALT7/EXTL2/B3GALT6/XYLT1	0.746491890610117
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1439	30/9376	1.30312717164698	GPAA1/PIGU/MPPE1/PIGN/PIGX/PIGH	0.708044333294377
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/1439	109/9376	1.13575303950883	RORA/MTOR/PPP3CB/TGFBR2/STAT6/MAPK1/PPP3CC/SMAD4/IKBKG/RXRA/TYK2/JAK3/IL2RB/MAPK9/SMAD3/STAT5A/RXRB/CD247/IL2RA	0.606989354910545
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1439	36/9376	1.26692919465678	C1GALT1C1/GALNT15/GALNT11/GCNT1/GALNT6/B4GALT5/ST6GALNAC4	0.683221828684345
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1439	42/9376	1.24107349680664	SAT2/VDAC2/ACSL5/TP53/PRNP/ACSL4/ACSL3/MAP1LC3A	0.666696322213592
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1439	128/9376	1.11987491313412	NUDT5/NME4/PAPSS1/NME1/NME3/HDDC2/ITPA/IMPDH1/ATIC/PAICS/GMPR2/NTPCR/PGM1/NT5E/ADCY9/PDE4D/NME2/IMPDH2/NUDT9/PDE6D/ADCY3/NME6	0.581429716847554
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1439	13/9376	1.50360827497728	RAD50/PRKDC/POLL	0.773650600604142
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1439	110/9376	1.12542801187693	ANAPC5/ANAPC15/CDC16/RAF1/MAD2L2/AKT1/MAPK1/PRKACB/AKT2/CDC26/ANAPC1/MAPK9/ADCY9/PGR/PRKACA/GNAI3/ADCY3/IGF1R/ANAPC7	0.563420413611131
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/1439	98/9376	1.13026336316319	FCGR1A/RAF1/ARPC4/PIP5K1C/AKT1/MAPK1/CRK/AKT2/BIN1/RPS6KB2/INPPL1/PIP5K1A/PLCG2/PRKCD/SPHK2/DOCK1/MYO10	0.551945231264225
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	36/1439	217/9376	1.08093498108966	BAD/MTOR/KPNA1/EPHX1/NOTCH2/RAF1/SOS2/ATF2/AKT1/ATF4/GSTM3/MAPK1/PRKACB/AKT2/KPNA3/VEGFA/RXRA/SOS1/RPS6KB2/ADCY9/PGR/PRKACA/MAP2K2/KPNA4/GNAI3/GSTA4/GSTO1/STAT5A/ARNT/RXRB/PAQR7/KPNB1/ADCY3/IKBKE/GSTT2B/GSTM4	0.513605838508521
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1439	55/9376	1.18466106513362	GLB1/CERS5/DEGS1/CERS4/CERS2/GALC/B4GALT5/SMPD4/SPHK2/UGCG	0.58480795560038
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1439	31/9376	1.26109081127127	DLD/ACO2/CS/ACSS1/GCSH/MMUT	0.619969931527975
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/1439	193/9376	1.08031268115812	CCR1/BAD/GNB2/GNG10/PTK2B/RAF1/SOS2/AKT1/MAPK1/PRKACB/CRK/AKT2/XCL1/IKBKG/ROCK2/GNB5/SOS1/GNG11/ROCK1/JAK3/ADCY9/ITK/PRKACA/PLCG2/GNAI3/GSK3B/BCAR1/GRK6/ADCY3/PIK3R6/PRKCD/SHC1	0.480018894042352
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1439	149/9376	1.09322749299243	MTOR/DGKZ/PTK2B/RAF1/CYTH4/SOS2/PIP5K1C/AKT1/MAPK1/AGPAT2/RALB/AKT2/SOS1/GNA12/ADCY9/PIP5K1A/MAP2K2/PLCG2/TSC2/ADCY3/PIK3R6/AGPAT5/SPHK2/SHC1/PDGFRA	0.488421445452747
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	31/1439	187/9376	1.08013214762183	RBCK1/GABARAPL1/NEK7/MFN2/ATG12/VDAC2/ANTXR2/MAPK1/TRIP6/IKBKG/RIPK1/TXN2/MFN1/CARD6/MAVS/PKN1/TYK2/VDAC1/MAPK9/PANX1/MCU/SUGT1/MYD88/CASP8/TP53BP1/MAP1LC3A/IKBKE/PRKCD/TRAF2/RNASEL/NOD2	0.471282490689249
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/1439	62/9376	1.155999910332	NCOR2/NOTCH2/ITCH/DVL3/HDAC1/CTBP2/RFNG/EP300/TLE3/RBPJ/CTBP1	0.52473486581044
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/1439	93/9376	1.12096961001891	NOTCH2/PPP3CB/STAT6/MAPK1/PPP3CC/STAT4/IKBKG/TYK2/JAK3/IL2RB/MAPK9/STAT5A/CD247/IL2RA/RUNX3/RBPJ	0.499184882616856
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1439	75/9376	1.12937688209405	ATF2/ATF4/PRKACB/GPX7/TTF1/PDIA4/ADCY9/PRKACA/GPX8/ADCY3/GSR/CGA/GPX3	0.478972230805934
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	24/1439	144/9376	1.08593930970581	ALDH7A1/AKT1/AKT2/TRADD/IKBKG/RIPK1/FAS/ACOX1/ACADVL/MAPK9/SREBF1/MAP2K7/CASP3/GSK3B/CPT1A/ALDH9A1/MYD88/FOXO1/CASP8/IKBKE/SCD5/ADH5/ACACA/IL17RC	0.44249977490815
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/1439	119/9376	1.09506485012351	TNFRSF1B/MMP14/ITCH/ATF2/AKT1/ATF4/MAPK1/AKT2/TRADD/CASP7/IKBKG/RIPK1/FAS/MAPK9/MAP2K7/CASP3/FRMD8/CASP8/TRAF2/NOD2	0.444371463399625
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/1439	138/9376	1.08593930970581	PPP2R5E/ANAPC5/SLK/ANAPC15/CDC16/SMC3/PPP3CB/MAD2L2/MAPK1/PPP3CC/PRKACB/CDC26/PPP2R5A/ANAPC1/ADCY9/PGR/YWHAG/PRKACA/PPP2R1B/PPP1CB/ADCY3/IGF1R/ANAPC7	0.433042249625368
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1439	20/9376	1.30312717164698	SC5D/NSDHL/LIPA/CYP51A1	0.577806740118304
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1439	76/9376	1.11451665996123	RXRA/ACSL5/ACOX1/SCP2/ILK/ACAA1/HMGCS1/CPT1A/ACSL4/RXRB/ACSL3/SCD5/PDPK1	0.426797473230772
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/1439	115/9376	1.07649635918663	NACA/MMP14/MEF2D/RAF1/ATF2/ATF4/MAPK1/PRKACB/ARHGEF1/RXRA/GNA12/ADCY9/PRKACA/GNAI3/GNA11/RXRB/PDE4D/ADCY3/SP1	0.351437894745354
NA	NA	hsa04518	Integrin signaling	25/1439	154/9376	1.0577330938693	ACTG1/COL1A2/MTOR/COL6A1/PARVB/ITGAE/LAMB2/ITGAD/AKT1/AKT2/COL6A3/ACTN1/VEGFA/ACTN4/ITGB5/COL1A1/ITGA5/ILK/GSK3B/LAMA4/IGF1R/COL6A2/PDGFRA/ICAM3/FERMT1	0.307581689486365
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1439	65/9376	1.10264606831667	LDLR/ATF2/ATF4/PRKACB/SCARB1/ADCY9/PRKACA/GNA11/ADCY3/SP1/KCNK3	0.35358080409133
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1439	91/9376	1.07400591069806	BCL10/RAF1/PPP3CB/SOS2/AKT1/MAPK1/PPP3CC/AKT2/IKBKG/SOS1/INPPL1/CARD11/MAP2K2/PLCG2/GSK3B	0.302053584874602
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/1439	168/9376	1.04715576293061	RBCK1/PPID/CHMP2B/CHMP4A/VDAC2/STAT6/CHMP4B/TRADD/VPS4B/STAT4/RIPK1/BID/CAPN2/TYK2/FAS/JAK3/CHMP3/VDAC1/MAPK9/CAPN1/STAT5A/CASP8/PYGB/SLC25A4/CHMP6/TRAF2/CHMP7	0.262599930154639
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/1439	181/9376	1.04394165684426	BCL10/BAD/FCGR1A/RAF1/PPP3CB/LAMP1/AKT1/MAPK1/PPP3CC/PIK3C3/ARHGEF12/AKT2/TRADD/APAF1/LAMP2/NFYB/RAB5B/BID/ATP6V0A2/MAPK9/KSR1/CASP3/EP300/MYD88/CASP8/RFXANK/SPHK2/NOD2/EEA1	0.254171992742627
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	57/1439	362/9376	1.02594266276074	COL1A2/BAD/MTOR/COL6A1/PPP2R5E/EIF4E2/GNB2/GNG10/RAF1/CSF1R/LAMB2/SOS2/ATF2/AKT1/ATF4/MAPK1/AKT2/CDKN1B/COL6A3/EPOR/IKBKG/GNB5/VEGFA/IRS1/RXRA/SOS1/RPS6KB2/ITGB5/PKN1/PPP2R5A/GNG11/TP53/AREG/JAK3/PPP2R3A/IL2RB/YWHAG/RBL2/COL1A1/CDK4/MAP2K2/RPS6/ITGA5/PPP2R1B/GSK3B/LAMA4/NTRK1/TSC2/IL2RA/MDM2/IGF1R/PIK3R6/COL6A2/PDGFRA/PDPK1/EIF4B/THEM4	0.214337373001058
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1439	22/9376	1.18466106513362	CNDP2/ALDH7A1/CARNMT1/ALDH9A1	0.369212026381079
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1439	41/9376	1.11242563433279	DLD/ALDH7A1/SDSL/PGAM1/GCSH/PSPH/GAMT	0.307176479617673
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1439	41/9376	1.11242563433279	BABAM1/SSBP1/POLD2/RAD50/RPA1/POLD1/UIMC1	0.307176479617673
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1439	105/9376	1.05491247228565	BCL10/RAF1/PPP3CB/AKT1/MAPKAPK2/MAPK1/PPP3CC/ARHGEF12/AKT2/IKBKG/MAPK9/KSR1/PLCG2/CASP8/MDM2/IKBKE/PRKCD	0.240929623023357
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1439	73/9376	1.07106342875094	BAD/POLK/RAF1/AKT1/MAPK1/AKT2/TP53/CDK4/MAP2K2/MDM2/IGF1R/PDGFRA	0.259527822310229
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1439	29/9376	1.12338549279912	LATS1/RASSF4/RASSF1/NF2/LIMD1	0.28334452325397
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/1439	133/9376	1.02878460919498	PTK2B/RAF1/KLRD1/PPP3CB/PRF1/SOS2/KLRK1/KLRC1/MAPK1/PPP3CC/GZMB/BID/SOS1/FAS/KLRC2/MAP2K2/PLCG2/CASP3/CD247/SHC1/KIR2DL4	0.142353295784816
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	21/1439	133/9376	1.02878460919498	PPP2R5E/GNB2/GNG10/PPP3CB/ATF2/AKT1/ATF4/PPP3CC/PRKACB/AKT2/GNB5/PPP2R5A/GNG11/PPP2R3A/MAPK9/KIF5B/PRKACA/PPP2R1B/GNAI3/GSK3B/PPP1CB	0.142353295784816
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1439	36/9376	1.08593930970581	SSBP1/POLD2/RFC1/RPA1/RNASEH1/POLD1	0.219966993151772
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1439	166/9376	1.02052127900064	BAD/MEF2D/VDAC2/RAF1/PPP3CB/ATF2/AKT1/ATF4/MAPK1/PPP3CC/AKT2/ROCK2/IRS1/GTF2I/ROCK1/GNA12/VDAC1/ADCY9/MAP2K2/GNAI3/PPP1CB/GNA11/PPP1R12A/ADCY3/SLC25A4/PIK3R6	0.113583827397931
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1439	69/9376	1.03872455710991	RAF1/SOS2/AKT1/MAPK1/AKT2/SOS1/MAPK9/MAP2K2/MAP2K7/PLCG2/PDPK1	0.137465587624361
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1439	17/9376	1.14981809262969	ACOT8/SCP2/HSD17B4	0.26324603933147
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1439	17/9376	1.14981809262969	LAMP1/LAMP2/DAG1	0.26324603933147
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1439	30/9376	1.08593930970581	ATIC/ABCC5/IKBKG/MTR/MTHFR	0.20073700722315
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1439	89/9376	1.02493148331785	GNB2/GABARAPL1/GNG10/NSF/PRKACB/GNB5/GNG11/ADCY9/PRKACA/SLC38A1/GPHN/GNAI3/PLCL1/ADCY3	0.100622069101512
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	31/1439	200/9376	1.00992355802641	ACTG1/MYO1C/BAIAP2L1/PAK2/ABCF2/ARPC4/CYTH4/CYFIP1/MAPK1/ARHGEF1/ARHGEF12/TRADD/CASP7/RPS3/IKBKG/ROCK2/RIPK1/ROCK1/FAS/GNA12/MAPK9/ARHGEF2/CASP3/NCKAP1/MYD88/CASP8/ABL1/WASL/SEC24A/TRAF2/MYO10	0.0604009200350525
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/1439	142/9376	1.00946471043076	ACTG1/SUMO1/BMPR2/AKT1/GSTM3/SDC2/AKT2/ACVR1/IKBKG/VEGFA/TXN2/TP53/MAPK9/KEAP1/ARHGEF2/MAP2K7/GSTA4/GSTO1/NCF2/BMP4/GSTT2B/GSTM4	0.0483887511324566
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/1439	90/9376	1.01354335572543	MTOR/RAF1/PPP3CB/AKT1/MAPK1/PPP3CC/AKT2/IKBKG/RPS6KB2/MAP2K2/EML4/MYD88/CD247/CSNK2A2	0.0549694062181914
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1439	38/9376	1.02878460919498	CD38/NNT/SIRT7/NT5E/QPRT/NUDT12	0.0757029922770826
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	28/1439	183/9376	0.996927890877469	RPP25/NOP56/LSG1/UTP6/NHP2/IMP3/GNL3/GTPBP4/GAR1/MDN1/XRN2/MPHOSPH10/NOP58/WDR43/EMG1/UTP14A/NVL/FBL/RPP38/NMD3/RIOK2/RBM28/BMS1/DKC1/NXF1/NAT10/CSNK2A2/NOB1	-0.0178698701918421
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1439	216/9376	0.99544436723033	BAD/PPP3CB/LDLR/AKT1/ATF4/ERO1A/MAPK1/PPP3CC/ARHGEF1/AKT2/APAF1/CASP7/IKBKG/ROCK2/HSPA4/RXRA/BID/FAS/TP53/HSPA2/EIF2S1/MAPK9/MAP2K7/CASP3/GSK3B/MYD88/RXRB/NCF2/CASP8/MIB2/IKBKE/TRAF2/PDPK1	-0.0288413571146571
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1439	65/9376	1.00240551665152	DGKZ/ALDH7A1/AGPAT2/GPAT4/MBOAT1/ABHD16A/MGLL/ALDH9A1/MBOAT2/AGPAT5	0.00828618695141632
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1439	52/9376	1.00240551665152	LDLR/PRKACB/SCARB1/ADCY9/PRKACA/ADCY3/IGF1R/CGA	0.00740622244582847
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/1439	112/9376	0.988980442767795	BAD/LAMB2/LDLR/AKT1/MAPK1/AKT2/IKBKG/TYK2/MAPK9/CASP3/GNAI3/LAMA4/MYD88/SOCS1/CASP8/PIK3R6/PDPK1	-0.0499530175364734
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1439	26/9376	1.00240551665152	PLAAT3/ACOX1/ACAA1/PLA2G12A	0.00522970366882185
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1439	26/9376	1.00240551665152	BTD/LMBRD1/SLC19A2/SCARB1	0.00522970366882185
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/1439	67/9376	0.972482963915654	RAF1/PPP3CB/ATF4/MAPK1/PPP3CC/PRKACB/PRKACA/MAP2K2/EP300/PPP1CB	-0.0962443811976233
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1439	134/9376	0.972482963915654	RAF1/MAPK1/PRKACB/ARHGEF1/ARHGEF12/PRKCH/ROCK2/ROCK1/GNA12/ADCY9/PRKACA/MAP2K2/PPP1CB/MYL6/PPP1R12C/GNA11/PPP1R12A/ADCY3/PLA2G12A/PRKCD	-0.136602584261869
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/1439	94/9376	0.970413851226472	ANAPC5/SRSF1/ELAVL1/MAPK1/TRADD/IKBKG/MAPK9/CASP3/GSK3B/MAPK6/CASP8/IKBKE/TRAF2/IL17RC	-0.122749413728473
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/1439	155/9376	0.966836288641306	USP8/KMT2A/LDLR/ATF2/ATF4/MAPK1/PRKACB/CDKN1B/ASH2L/DVL3/SCARB1/ADCY9/PRKACA/CDK4/MAP2K2/GNAI3/GSK3B/ARNT/GNA11/ADCY3/SP1/FH/KCNK3	-0.177266965207062
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1439	20/9376	0.977345378735233	GMPPA/UGP2/GNE	-0.0431831722325922
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1439	27/9376	0.965279386405168	HMGCL/HADHA/ECHS1/HMGCS1	-0.076926245892324
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/1439	116/9376	0.95487766887925	ACTG1/PTK2B/ARHGAP35/SIPA1/RHOH/ACTN1/ROCK2/ACTN4/ROCK1/ITK/PLCG2/GNAI3/AFDN/BCAR1/NCF2/ARHGAP5/MSN	-0.208210618603024
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1439	89/9376	0.951722091652287	CSNK1D/RAF1/SOS2/MAPK1/PRKACB/SOS1/ADCY9/PRKACA/MAP2K2/GNAI3/GNA11/ADCY3/PDGFRA	-0.194846931805401
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1439	83/9376	0.942019642154441	CASP7/POLR1D/IKBKG/RIPK1/MAVS/POLR3D/CASP3/POLR2H/POLR3A/CASP8/POLR1C/IKBKE	-0.225907065430485
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1439	56/9376	0.930805122604984	CSNK1G1/CSNK1D/PRKACB/MGRN1/PRKACA/MOSMO/GSK3B/HHAT	-0.221130091940561
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/1439	139/9376	0.937501562335955	EBAG9/RAF1/SOS2/ATF2/AKT1/ATF4/MAPK1/PRKACB/AKT2/SOS1/ADCY9/PGR/FKBP4/PRKACA/MAP2K2/GNAI3/ADCY3/SP1/PRKCD/SHC1	-0.316081395666363
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1439	105/9376	0.930805122604984	UBE2I/BCL10/LTBR/BCL2A1/TRADD/IKBKG/RIPK1/CARD11/TNFSF14/PLCG2/TNFRSF11A/MYD88/TRIM25/TRAF2/CSNK2A2	-0.303593974775124
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/1439	154/9376	0.930805122604984	ACTG1/RAF1/CD38/PPP3CB/EEF2/MAPK1/PPP3CC/PRKACB/ROCK2/ROCK1/RCAN1/ADCY9/PRKACA/MAP2K2/GNAI3/PPP1CB/MYL6/ELK1/PPP1R12C/PPP1R12A/ADCY3/PIK3R6	-0.368646054915111
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	24/1439	168/9376	0.930805122604984	MTOR/RAF1/STAT6/SOS2/STAM/PIM1/AKT1/AKT2/IL15RA/EPOR/STAT4/LEPR/SOS1/TYK2/JAK3/IL2RB/EP300/SOCS2/STAT5A/FHL1/SOCS1/IL2RA/SOCS5/PDGFRA	-0.385330844879544
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1439	44/9376	0.888495798850212	RPN1/MAN1B1/ALG13/STT3B/STT3A/MGAT2	-0.315658907312934
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1439	15/9376	0.868751447764651	ACP1/NTPCR	-0.216604200009801
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1439	115/9376	0.906523249841375	GNB2/GNG10/AKT1/ATF4/MAPK1/PRKACB/AKT2/GNB5/KCNQ5/GNG11/ADCY9/PRKACA/GNAI3/GNA11/ADCY3/PIK3R6	-0.429448834332561
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1439	52/9376	0.877104827070081	VDAC2/LDLR/VAPB/SCARB1/VDAC1/LIPA/OSBPL5	-0.378375675621317
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	21/1439	150/9376	0.912189020152884	MTOR/POLK/RAF1/TGFBR2/SOS2/AKT1/MAPK1/SMAD4/AKT2/CDKN1B/DVL3/RXRA/SOS1/RPS6KB2/TP53/SMAD3/MAP2K2/GSK3B/MLH1/RXRB/SHC1	-0.46161038710541
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1439	60/9376	0.868751447764651	RAF1/MAPK1/GNA12/MAP2K2/PPP2R1B/GNAI3/GNA11/IGF1R	-0.434253424347612
NA	NA	hsa04981	Folate transport and metabolism	4/1439	31/9376	0.840727207514179	ABCC5/MTR/MTHFR/BHMT2	-0.378199224135507
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1439	82/9376	0.874048712690046	TAPBP/KLRD1/TAP1/KLRC1/HSPA4/NFYB/HSPA2/KLRC2/PSME3/RFXANK/KIR2DL4	-0.487748618290065
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1439	98/9376	0.864319042418913	LDLR/ATF2/ATF4/PRKACB/ATF1/PRKD2/SCARB1/PRKD3/ADCY9/PRKACA/GNA11/ADCY3/KCNK3	-0.574900384050609
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1439	155/9376	0.882763567889888	ACTG1/ATP6V1C1/SEC22B/FCGR1A/TAP1/LAMP1/DYNC1LI2/STX12/PIKFYVE/PIK3C3/LAMP2/SEC61A1/DYNC1I2/RAB5B/ITGB5/SCARB1/ATP6V0A2/ATP6V1D/ITGA5/NCF2/EEA1	-0.626653220656952
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/1439	70/9376	0.837724610344485	ACTG1/PRF1/EIF4G1/SGCB/BID/CASP3/DAG1/CASP8/ABL1	-0.580240450386097
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1439	18/9376	0.723959539803876	GLB1/FUCA1	-0.499120399114819
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1439	144/9376	0.859701953517103	BMPR2/RAF1/AKT1/MAPK1/SMAD4/AKT2/REST/DVL3/ACVR1/SMARCAD1/TBX3/JAK3/BMI1/SMAD3/MAP2K2/GSK3B/SMAD5/IGF1R/BMP4	-0.722391815820402
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1439	35/9376	0.744644098083987	ENOSF1/PFKL/GMPPA/HK1	-0.644423072313743
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1439	10/9376	0.651563585823489	PAPSS1	-0.469390508989835
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1439	51/9376	0.766545395086457	CEPT1/LPCAT1/PLAAT3/PAFAH1B2/SELENOI/PLA2G12A	-0.711788484629071
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1439	103/9376	0.822361807350034	TGFBR2/AKT1/MAPK1/AKT2/IKBKG/FAS/MAPK9/PPP2R1B/GNAI3/MYD88/GNA11/CASP8/CD247	-0.771849582080064
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1439	103/9376	0.822361807350034	COL3A1/COL1A2/LAMB2/PRKACB/ACTN1/ACTN4/RAB5B/PRKACA/COL1A1/SERPINB6/CASP3/LAMA4/GNA11	-0.771849582080064
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1439	28/9376	0.698103841953738	ATP6V1C1/ATP6V0A2/ATP6V1D	-0.681185029775467
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/1439	148/9376	0.836466765584208	MTOR/POLK/NOTCH2/RAF1/SOS2/AKT1/MAPK1/AKT2/DVL3/SOS1/RPS6KB2/TP53/PGR/CDK4/MAP2K2/GSK3B/SP1/IGF1R/SHC1	-0.853829068549628
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1439	90/9376	0.796355493784264	SLC4A2/EPHX1/LDLR/PRKACB/RXRA/SCARB1/ADCY9/PRKACA/SLC2A1/SLC9A1/ADCY3	-0.826546818471253
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/1439	170/9376	0.843199934595103	ACTG1/ARPC4/WHAMM/PRKACB/ACTN1/RAP2C/ROCK2/HSPA4/ACTN4/ROCK1/MAPK9/PRKACA/CDK4/ARHGEF2/MAP2K7/TJAP1/PPP2R1B/AFDN/MYL6/MSN/TJP2/NF2	-0.878462162121061
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1439	37/9376	0.704393065755123	FAS/LAMA4/APOL1/MYD88	-0.767102038280764
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1439	45/9376	0.723959539803876	TAP1/ABCC5/ABCA7/ABCD3/ABCA5	-0.79031959514773
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1439	45/9376	0.723959539803876	KLRD1/PRF1/KLRC1/GZMB/FAS	-0.79031959514773
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	23/1439	178/9376	0.841908004153946	SFRP2/INVS/PPP3CB/CHD8/SIAH1/PPP3CC/PRKACB/SMAD4/DVL3/ROCK2/TP53/MAPK9/SMAD3/CTBP2/PRKACA/GSK3B/EP300/RUVBL1/TLE3/VANGL1/SENP2/CTBP1/CSNK2A2	-0.906694592943128
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/1439	91/9376	0.787604334511909	GNB2/GNG10/PRKACB/GNB5/GNG11/ADCY9/PRKACA/GNAI3/PDE4D/GRK6/ADCY3	-0.866888489951224
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1439	69/9376	0.75543604153448	PPP3CB/ATF2/ATF4/PPP3CC/PRKACB/HDAC1/PRKACA/PPP1CB	-0.868160432843268
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1439	46/9376	0.708221288938575	HMOX2/COX15/UROD/UROS/HMBS	-0.84465535628489
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1439	38/9376	0.685856406129988	TAP1/IKBKG/JAK3/RFXANK	-0.826191868701225
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1439	70/9376	0.744644098083987	CBR1/EPHX1/GSTM3/GSTA4/GSTO1/SULT1A1/GSTT2B/GSTM4	-0.913064044098323
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1439	12/9376	0.542969654852907	CD46	-0.674516848348711
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1439	116/9376	0.786369844959383	HOMER3/GNB2/GNG10/PPP3CB/MAPK1/PPP3CC/PRKACB/GNB5/GNG11/ADCY9/PRKACA/SLC38A1/GNAI3/ADCY3	-0.985766152334552
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1439	63/9376	0.723959539803876	PTGDS/CBR1/PLAAT3/LTA4H/PTGR1/PTGES2/PLA2G12A	-0.936022009981993
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1439	79/9376	0.742287629419164	CBR1/EPHX1/GSTM3/AKR7A2/GSTA4/GSTO1/ADH5/GSTT2B/GSTM4	-0.979411594565471
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1439	65/9376	0.701683861656065	RAF1/AKT1/MAPK1/AKT2/MAP2K2/GNA11/CGA	-1.02759766446832
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1439	49/9376	0.664860801860703	ATF2/ATF4/PRKACB/PRKACA/GNAI3	-1.00147502416246
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1439	89/9376	0.732093916655605	COL1A2/COL6A1/LAMB2/COL6A3/ITGB5/COL1A1/ITGA5/LAMA4/DAG1/COL6A2	-1.08125393452614
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/1439	142/9376	0.780040912605585	FCGR1A/CSF1R/PPP3CB/TGFBR2/AKT1/MAPK1/PPP3CC/AKT2/IKBKG/TYK2/MAPK9/MAP2K7/PLCG2/TNFRSF11A/NCF2/SOCS1/TRAF2	-1.12455057311241
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/1439	157/9376	0.788516441442438	ACTG1/LATS1/BMPR2/CSNK1D/TGFBR2/SMAD7/SMAD4/RASSF1/DVL3/AREG/SMAD3/YWHAG/PPP2R1B/GSK3B/PPP1CB/BMP4/NF2/DLG5/LIMD1	-1.13781688214627
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1439	14/9376	0.465402561302492	B4GALT4	-0.852303787030332
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1439	43/9376	0.606105661231152	AGPAT2/GOT2/SCARB1/PLA2G12A	-1.10227809975533
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1439	76/9376	0.685856406129988	ACTG1/SLC4A2/PRKACB/ADCY9/PRKACA/GNAI3/SLC9A1/ADCY3	-1.17079639015621
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	26/1439	212/9376	0.799087416575976	ACTG1/EVL/RAF1/CSF1R/SIPA1/APBB1IP/PFN2/AKT1/MAPK1/RALB/CRK/AKT2/PRKD2/VEGFA/PRKD3/ADCY9/SKAP1/MAP2K2/GNAI3/AFDN/BCAR1/RGS14/ADCY3/IGF1R/PLCE1/PDGFRA	-1.25985444696079
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	22/1439	184/9376	0.779043417832432	PLXNB2/BMPR2/PAK2/RAF1/PPP3CB/MAPK1/SSH1/PPP3CC/SEMA5A/ARHGEF12/ROCK2/RHOD/ROCK1/ILK/PLCG2/GNAI3/GSK3B/ABL1/UNC5C/RGS3/PDPK1/NEO1	-1.28883906789832
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/1439	101/9376	0.709623707332512	RAF1/MAPK1/PRKACB/DVL3/ADCY9/PRKACA/MAP2K2/GNAI3/GSK3B/EP300/ADCY3	-1.2492596961843
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1439	109/9376	0.717317709163474	AKT1/MAPK1/AKT2/IKBKG/RIPK1/TYK2/MAPK9/MAP2K2/MAP2K7/MYD88/CASP8/IKBKE	-1.26395064140228
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1439	53/9376	0.614682628135367	PRKACB/ADCY9/PRKACA/AP2M1/AP2A1	-1.19775095866953
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1439	16/9376	0.40722724113968	GOT2	-1.01041119453802
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1439	16/9376	0.40722724113968	GBGT1	-1.01041119453802
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/1439	79/9376	0.659811226150368	ATP6V1C1/NSF/STX2/ATP6V0A2/ATP6V1D/AP2M1/AP2A1/STXBP1	-1.29285539804862
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/1439	71/9376	0.642386633910482	ATP6V1C1/IKBKG/ATP6V0A2/ATP6V1D/MAPK9/PLCG2/CASP3	-1.28787162041885
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1439	17/9376	0.383272697543229	CA5B	-1.08365429615113
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/1439	97/9376	0.671715036931431	GNB2/GNG10/MAPK1/PRKACB/GNB5/GNG11/ADCY9/PRKACA/GNAI3/ADCY3	-1.38380251419506
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1439	28/9376	0.465402561302492	CBR1/GPHN	-1.20624182352545
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/1439	38/9376	0.514392304597491	MAPK1/IRS1/PDPK1	-1.27713929919038
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1439	154/9376	0.719258503831124	PPP2R5E/ATF2/AKT1/ATF4/MAPK1/PRKACB/AKT2/PPP2R5A/PPP2R3A/ADCY9/PRKACA/PPP2R1B/GNAI3/PPP1CB/SLC9A1/ADCY3/PIK3R6	-1.49569229558424
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/1439	99/9376	0.658145036185342	PRKACB/PRKCH/MAPK9/ADCY9/PRKACA/PLCG2/PPP1CB/NTRK1/ADCY3/PRKCD	-1.45594025645343
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1439	39/9376	0.50120275832576	PRF1/GZMB/FAS	-1.32904752893915
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1439	30/9376	0.434375723882326	PLAAT3/PLA2G12A	-1.32118497099053
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1439	31/9376	0.420363603757089	ALDH7A1/ALDH9A1	-1.37636837979899
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1439	86/9376	0.606105661231152	ATF2/ATF4/PRKACB/ADCY9/PRKACA/SLC2A1/GNA11/ADCY3	-1.56246016074012
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/1439	78/9376	0.584736551380054	MAPK1/CASP7/MAPK9/ITGA5/CASP3/GNAI3/MYD88	-1.56806507397544
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1439	191/9376	0.716378811638391	HDAC7/GNB2/GNG10/RAF1/SOS2/ATF2/ATF4/MAPK1/PRKACB/GNB5/SOS1/GNG11/HDAC8/HDAC1/PRKACA/GNAI3/PPP1CB/HDAC6/HDAC4/SHC1/HDAC3	-1.68617878441612
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1439	105/9376	0.620536748403322	ACTG1/EMD/PRKACB/SGCB/ITGB5/ADCY9/PRKACA/ITGA5/DAG1/ADCY3	-1.66490296927133
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1439	63/9376	0.517113957002769	POLK/DVL3/TP53/GSK3B/BMP4	-1.63741200923004
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1439	44/9376	0.444247899425106	PRF1/GZMB/FAS	-1.57328691650532
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1439	54/9376	0.482639693202584	PRF1/GZMB/FAS/CGA	-1.62339155014399
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/1439	34/9376	0.383272697543229	RORA/CSNK1D	-1.53391236055219
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1439	73/9376	0.53553171437547	GSTM3/GSTA4/GSTO1/ADH5/GSTT2B/GSTM4	-1.69626550279148
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/1439	100/9376	0.58640722724114	CCR1/LTBR/TNFRSF1B/CSF1R/XCL1/IL2RB/TNFSF14/TNFRSF10D/IL2RA	-1.77043675112595
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1439	23/9376	0.28328851557543	GOT2	-1.46528012674786
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1439	23/9376	0.28328851557543	NLN	-1.46528012674786
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1439	66/9376	0.493608777139007	RORA/STAT6/STAT4/SMAD3/NOD2	-1.75780680677978
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/1439	93/9376	0.560484805009453	SLC4A2/CD38/PRKACB/ADCY9/PRKACA/SLC9A1/ADCY3/SLC12A2	-1.81367321086175
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1439	36/9376	0.361979769901938	FGGY/UGP2	-1.63305234897852
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1439	37/9376	0.352196532877561	GOT2/ADH5	-1.68105447629086
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1439	48/9376	0.40722724113968	AKT1/AKT2/HK1	-1.75308281392424
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1439	226/9376	0.691925931847952	BAD/RAF1/AKT1/MAPK1/PRKACB/AKT2/ROCK2/ROCK1/ACOX1/MAPK9/ADCY9/PRKACA/MAP2K2/GNAI3/AFDN/EP300/PPP1CB/PDE4D/PPP1R12A/SLC9A1/ADCY3/VIPR2/CGA/PLCE1	-1.99612006904572
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/1439	195/9376	0.668270344434347	ACTG1/HDAC7/MTOR/VDAC2/FCGR1A/RAF1/AKT1/MAPK1/AKT2/SIGLEC9/VDAC1/HDAC8/HDAC1/MAP2K2/PLCG2/NCF2/SLC25A4/HDAC6/HDAC4/HDAC3	-1.99317051851249
NA	NA	hsa04081	Hormone signaling	23/1439	219/9376	0.684290523924212	APPL1/GNB2/GNG10/PRKACB/SMAD4/EPOR/ACVR1/GNB5/IRS1/LEPR/GNG11/GNA12/HAMP/ADCY9/PRKACA/GNAI3/STAT5A/GNA11/SMAD5/ADCY3/VIPR2/IGF1R/CGA	-2.01289403489303
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/1439	78/9376	0.50120275832576	EEF1A1/FCGR1A/MAPK1/ELK1/MYD88/NCF2	-1.88349477004053
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/1439	69/9376	0.47214752595905	PPP3CB/PPP3CC/PRKACB/PRKACA/GNAI3	-1.8737864533109
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1439	115/9376	0.56657703115086	GNB2/GNG10/RAF1/MAPK1/PRKACB/GNB5/GNG11/PRKACA/CASP3/GNAI3	-1.99122229248839
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/1439	50/9376	0.390938151494093	KLRK1/SDC2/MYD88	-1.83859696070862
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/1439	323/9376	0.726200900608222	ZEB1/UBE2I/MTOR/BMPR2/NOTCH2/RAF1/SOS2/PIM1/FSCN1/MAPK1/CRK/CDKN1B/RASSF1/CCNG1/VEGFA/IRS1/SOS1/ROCK1/TP53/BMI1/HDAC1/SPRY2/MAP2K2/ITGA5/VIM/PLCG2/CASP3/EP300/SOCS1/DNMT3A/ABL1/MDM2/HDAC4/SHC1/HOXD10/PDGFRA	-2.13218488964566
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1439	28/9376	0.232701280651246	B4GALT4	-1.73129861727543
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/1439	233/9376	0.671138457500589	VCAN/COL3A1/ACTG1/COL1A2/COL6A1/EMD/FBLN1/TMEM43/SDC3/SDC2/SGCB/ZYX/COL6A3/INF2/ITGB5/COL1A1/ITGA5/VIM/TMOD3/DAG1/FHL1/PLEC/COL6A2/COL27A1	-2.16438509808951
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1439	103/9376	0.506068804523098	COL3A1/COL1A2/COL6A1/SLC1A5/COL6A3/COL1A1/COL6A2/COL27A1	-2.14616339604616
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/1439	86/9376	0.454579245923364	ACTG1/EMD/SGCB/ITGB5/ITGA5/DAG1	-2.16351979505265
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1439	68/9376	0.383272697543229	RDH11/ALDH1A1/ADH5/PNPLA4	-2.17323799416122
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/1439	194/9376	0.604543533238288	ACTG1/KLC1/TUBE1/MYO1C/KIF2A/DCTN4/DCTN2/DYNC1LI2/DYNC1I2/DYNLL2/DCTN5/KIF5B/MYL6/KIF21A/KIF1C/DNAH14/KIF13A/MYO10	-2.36983848305018
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/1439	100/9376	0.456094510076442	FCGR1A/CSF1R/CD38/EPOR/ITGA5/IL2RA/CD7	-2.32825700042216
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/1439	102/9376	0.4471514804671	SLC4A2/CD38/ADCY9/SLC9A1/ADCY3/SLC12A2/PLA2G12A	-2.39034471701764
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/1439	61/9376	0.320441107782044	CYBRD1/HMOX2/ATOX1	-2.26719268991576
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1439	50/9376	0.260625434329395	LTBR/IL15RA	-2.23197665820312
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/1439	37/9376	0.176098266438781	GOT2	-2.13803069529591
NA	NA	hsa04517	IgSF CAM signaling	29/1439	299/9376	0.631951303975959	ACTG1/CD2AP/PAK2/ARPC4/AKT1/MAPK1/AKT2/ACTN1/DYNLL2/ACTN4/MAPK9/NLGN2/MAP2K2/ITGA5/PLCG2/GSK3B/AFDN/DOK2/MYL6/BCAR1/FOXO1/ABL1/MSN/WASL/UNC5C/TJP2/PDPK1/ICAM3/CLMP	-2.75395953585201
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/1439	99/9376	0.394887021711205	ACTG1/EMD/SGCB/ITGB5/ITGA5/DAG1	-2.57714071184509
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1439	95/9376	0.342928203064994	ATP6V1C1/VEGFA/ATP6V0A2/ATP6V1D/TNFRSF11A	-2.74072264400208
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/1439	87/9376	0.299569464746432	MT-CO3/COX7A1/UQCRC2/SLC9A1	-2.7946540918074
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/1439	88/9376	0.296165266283404	CFD/CD46/PROS1/CFI	-2.82448174943412
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/1439	254/9376	0.538694303239892	PTK2B/VDAC2/CD38/PPP3CB/PPP3CC/PRKACB/VEGFA/VDAC1/ADCY9/PRKACA/PLCD1/MCU/PLCG2/NTRK1/GNA11/STIM1/ADCY3/SLC25A4/SPHK2/PLCE1/PDGFRA	-3.17357296053267
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1439	66/9376	0.197443510855603	HSD17B12/STS	-2.7858683084453
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/1439	160/9376	0.40722724113968	VCAN/VSIR/SDC3/SDC2/CD276/NLGN2/GLG1/SELL/ICAM3/NEO1	-3.22006649856373
NA	NA	hsa04519	Cadherin signaling	36/1439	404/9376	0.580601215090237	ACTG1/MYO1C/LATS1/EVL/PTK2B/ARHGAP35/RAF1/ARPC4/CYFIP1/TAOK1/MAPK1/ABI2/DVL3/ACTN1/IKBKG/ROCK2/ACTN4/TMC6/ROCK1/LIMA1/MAPK9/YWHAG/MAP2K2/VIM/NCKAP1/GSK3B/AFDN/EP300/PPP1CB/IGF1R/VANGL1/PDGFRA/NF2/KRT8/TAOK2/LIMD1	-3.66911279550969
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/1439	99/9376	0.197443510855603	CFD/FCGR1A/CFI	-3.41804105338884
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1439	86/9376	0.151526415307788	PRKACB/PRKACA	-3.36563906367772
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	20/1439	298/9376	0.437290997196972	CCR1/LTBR/TNFRSF1B/BMPR2/CSF1R/TGFBR2/IL15RA/EPOR/XCL1/ACVR1/TNFRSF12A/LEPR/FAS/IL2RB/TNFSF14/TNFRSF10D/TNFRSF11A/IL2RA/BMP4/IL17RC	-4.20324544833994
NA	NA	hsa04082	Neuroactive ligand signaling	10/1439	199/9376	0.327418887348487	GNB2/GNG10/PRKACB/GNB5/GNG11/ADCY9/PRKACA/GNAI3/GNA11/ADCY3	-4.0832755169133
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1439	143/9376	0.227819435602618	SSB/FCGR1A/ACTN1/ACTN4/RO60	-3.96189820043389
NA	NA	hsa04382	Cornified envelope formation	10/1439	217/9376	0.30025971696935	PPP2R5E/PPP2R5A/PPP2R3A/CAPN1/BLMH/PPP2R1B/FURIN/PLEC/UGCG/KRT8	-4.44048654815921
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/1439	370/9376	0.0704393065755123	LEPR/RXFP1/VIPR2/CGA	-7.76784385402713
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1439	449/9376	0.058045753748195	PRKACB/NCALD/PRKACA/ADCY3	-8.70939637690402