category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	64/359	222/9376	7.52922281613089	RPL13A/RPL3/RPL10/RPLP0/RPL6/RPS20/RPL37A/RPL18A/RPL12/RPL5/RPS27/RPS2/RPL7A/RPL9/RPS4X/RPL27A/RPS11/RPL10A/RPL37/RPS18/RACK1/RPS13/RPS29/RPS6/RPS9/RPL29/RPL7/RPS17/RPL23A/RPL17/RPL31/RPL30/RPS28/RPL13/RPL34/RPS7/RPS5/RPS8/RPS14/RPS23/RPS25/RPS3/MRPS33/RPL15/RPL11/RPS16/RPL35A/RPL8/RPS3A/RPL36/MRPL42/MRPL2/MRPS10/MRPS27/RPL24/RPL23/RPL39/MRPL24/MRPL17/RPL18/MRPL27/MRPS7/MRPL11/RPL4	19.644200150459
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	61/359	238/9376	6.69385079937267	CFD/RPL13A/RPL3/RPL10/RPLP0/RPL6/RPS20/RPL37A/RPL18A/RPL12/RPL5/RPS27/JUN/RPS2/RPL7A/RPL9/RPS4X/RPL27A/RPS11/RPL10A/RPL37/C1R/RPS18/RPS13/RPS29/RPS6/RPS9/RPL29/RPL7/RPS17/RPL23A/RPL17/RPL31/RPL30/RPS28/RPL13/RPL34/RPS7/RPS5/RPS8/RPS14/RPS23/RPS25/C1S/RPS3/CXCL8/RPL15/RPL11/RPS16/RPL35A/STAT2/RPL8/RPS3A/RPL36/RPL24/C1QB/RPL23/RPL39/MAPK3/RPL18/RPL4	17.7529615354084
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/359	89/9376	3.52139213170167	COL1A1/COL6A1/COL1A2/COL6A3/COL4A1/COL6A2/ITGB8/COL4A2/FN1/LAMA2/TNXB/SPP1	4.76869450658969
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/359	233/9376	2.35389195069757	VCAN/COL3A1/FBLN1/COL1A1/COL6A1/COL1A2/VIM/COL6A3/DCN/COL4A1/COL6A2/ITGB8/FBLN2/COL4A2/FN1/TPM2/PDLIM1/FBN1/LAMA2/FMNL2/FHL3	4.17560524577769
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/359	203/9376	2.4444474937223	COL1A1/COL6A1/COL1A2/JUN/COL6A3/COL4A1/COL6A2/ITGB8/COL4A2/FN1/PAK3/LAMA2/XIAP/RAF1/MAPK3/PPP1R12C/TNXB/SPP1/CAV1	4.15141269952764
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/359	101/9376	2.84442483245539	COL3A1/COL1A1/COL1A2/JUN/EGR1/COL4A1/COL4A2/FN1/FOXO1/CXCL8/MAPK3	3.71848912860453
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/359	103/9376	2.78919328231063	COL3A1/COL1A1/COL1A2/HSPB1/RAB7A/COL4A1/COL4A2/FN1/IL1R1/LAMA2/CXCL8	3.6430704438936
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/359	362/9376	1.80365964388495	COL1A1/COL6A1/COL1A2/COL6A3/COL4A1/COL6A2/ITGB8/COL4A2/RPS6/FN1/LAMA2/GNG4/INSR/CSH1/RAF1/MAP2K2/MAPK3/EIF4E2/FGF10/CREB3/TNXB/SPP1/ANGPT2/CREB3L2/STK11	3.1114977884731
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/359	110/9376	2.6116991643454	TIMP1/RPS6/INSR/MAP2K2/MAPK3/MKNK2/EIF4E2/PDHB/ARNT/ANGPT2/EGLN2	3.39262613260525
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	20/359	268/9376	1.94902922712344	UBC/TXN/MT-CO3/SLC25A6/SDHC/NDUFA5/UBE2J2/NDUFB1/NDUFA8/SLC39A14/UBA1/MFN1/PSMC4/NDUFS2/SLC39A6/PSMB6/NDUFB5/PSMD3/PSMB4/PSMC5	3.14512058598353
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/359	95/9376	2.74915701510043	JUN/CXCL12/IL15/CXCL8/HLA-DMA/ATP6V1E1/HLA-DRB5/CCL5/HLA-DPA1/ATP6V1D	3.41896803243101
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/359	130/9376	2.41079922862653	COL3A1/COL1A1/COL1A2/JUN/COL4A1/COL4A2/GNG4/RAF1/MAP2K2/MAPK3/CREB3/CREB3L2	3.23192871199594
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/359	275/9376	1.89941757406938	EGR1/MT-CO3/SLC25A6/SDHC/NDUFA5/NDUFB1/C1QB/NDUFA8/CCL5/MAPK3/PSMC4/NDUFS2/CREB3/PSMB6/NDUFB5/PSMD3/CREB3L2/CAV1/PSMB4/PSMC5	3.02054274882067
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/359	42/9376	3.73099880620772	FTL/MAP1LC3B/SAT1/FTH1/SAT2/SLC39A14	3.53927317817419
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/359	70/9376	2.98479904496618	JUN/PAK3/RAF1/MAP2K2/MAPK3/ARNT/ARAF/EGLN2	3.32572140657324
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/359	30/9376	4.35283194057567	SUCLA2/SDHC/DLST/PDHB/DLD	3.66996017766619
NA	NA	hsa04518	Integrin signaling	13/359	154/9376	2.20468111275911	COL1A1/COL6A1/COL1A2/COL6A3/COL4A1/COL6A2/ITGB8/COL4A2/FN1/FBN1/LAMA2/TNXB/SPP1	3.00761145723629
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	12/359	138/9376	2.2710427516047	RPS6/FOXO1/INSR/RAF1/MAP2K2/MAPK3/MKNK2/EIF4E2/SREBF1/SOCS2/ARAF/FLOT1	3.00132171356701
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/359	308/9376	1.78070397569005	TGM2/SOD2/MT-CO3/SLC25A6/SDHC/NDUFA5/NDUFB1/PIK3C3/POLR2H/NDUFA8/DCTN2/PSMC4/NDUFS2/CREB3/PSMB6/NDUFB5/PSMD3/CREB3L2/PSMB4/PSMC5/GPX3	2.77976332777918
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	22/359	333/9376	1.72544689536333	COL1A1/COL6A1/COL1A2/COL6A3/COL4A1/COL6A2/ITGB8/COL4A2/FN1/TCF7L2/FOXO1/LAMA2/STAT2/ATP6V1E1/RAF1/MAP2K2/MAPK3/CREB3/TNXB/ATP6V1D/SPP1/CREB3L2	2.68951087951086
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/359	204/9376	1.92036703260691	COL1A1/DDX5/COL1A2/TIMP3/DCN/RPS6/FN1/TWIST2/RAF1/MAP2K2/MAPK3/PPP1R12C/NUDT16L1/ARAF/CAV1	2.6518316047018
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/359	37/9376	3.52932319506136	GPI/CMAS/PMM1/UXS1/NAGK	3.07579104874407
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/359	37/9376	3.52932319506136	TCF7L2/CCDC6/POLK/MAP2K2/MAPK3	3.07579104874407
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/359	116/9376	2.25146479684949	GPI/SUCLA2/SDHC/TALDO1/DLST/PDHB/ECHS1/CAT/DLD/H6PD	2.706100780423
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/359	227/9376	1.84084522597033	JUN/SOD2/MT-CO3/SLC25A6/SDHC/NDUFA5/NDUFB1/RAF1/MAP2K2/NDUFA8/MAPK3/NDUFS2/ARNT/CAT/NDUFB5/ARAF	2.55884515059742
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/359	103/9376	2.28206723098142	COL3A1/COL1A1/COL6A1/COL1A2/COL6A3/COL4A1/COL6A2/COL4A2/COL15A1	2.6104844470694
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	28/359	480/9376	1.52349117920149	MAP1LC3B/UBC/MT-CO3/SLC25A6/SDHC/NDUFA5/UBE2J2/NDUFB1/PIK3C3/RAF1/MAP2K2/NDUFA8/DCTN2/MAPK3/UBA1/MFN1/CCS/ATXN2/PSMC4/NDUFS2/PSMB6/CAT/NDUFB5/ARAF/PSMD3/PSMB4/PSMC5/GPX3	2.34927808512711
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/359	157/9376	1.99620318293916	JUN/MT-CO3/CXCL8/INSR/SDHC/NDUFA5/NDUFB1/NDUFA8/SREBF1/NDUFS2/NDUFB5/MLXIP	2.51164162173351
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/359	235/9376	1.77817815444793	RPS6/MT-CO3/COA3/SDHC/NDUFA5/SMARCC2/NDUFB1/PRKG1/NDUFA8/NDUFS2/CREB3/NDUFB5/ATP5ME/CREB3L2/KDM1A/BMP8A	2.41055996330748
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/359	41/9376	3.18499898090903	CXCL8/RAF1/MAP2K2/MAPK3/ARAF	2.79761426403348
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/359	106/9376	2.21748042255742	ZEB1/TCF7L2/FOXO1/RAF1/MAP2K2/MAPK3/CREB3/ARAF/CREB3L2	2.51522522317376
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/359	90/9376	2.32151036830703	SOD2/FOXO1/INSR/EIF4E2/CREB3/CAT/CREB3L2/STK11	2.51350247713571
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	23/359	388/9376	1.54817218505011	APOE/MT-CO3/SLC25A6/INSR/SDHC/NDUFA5/NDUFB1/PIK3C3/RAF1/MAP2K2/NDUFA8/RTN3/MAPK3/SLC39A14/PSMC4/NDUFS2/SLC39A6/PSMB6/NDUFB5/ARAF/PSMD3/PSMB4/PSMC5	2.20040768812872
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/359	59/9376	2.65596525187668	TCF7L2/POLK/RAF1/MAP2K2/MAPK3/ARAF	2.54589803113328
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/359	44/9376	2.96783995948341	RAB11B/DCTN2/CREB3/NSF/CREB3L2	2.61054134635599
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	13/359	187/9376	1.81561973991926	JUN/TXNIP/MAP1LC3B/TXN/CXCL8/XIAP/STAT2/GBP3/CCL5/MAPK3/MFN1/RBCK1/CASP4	2.24789609742667
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/359	248/9376	1.68496720280349	JUN/RAB7A/PAK3/TCF7L2/TXN/RPS3/CXCL8/M6PR/ANXA2/PIK3C3/RAF1/MAP2K2/DCTN2/MAPK3/RAB9A/CASP4	2.18127102139926
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/359	46/9376	2.83880343950587	PSMC4/PSMB6/PSMD3/PSMB4/PSMC5	2.49445244626104
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/359	133/9376	1.96368358221459	SOD2/FOXO1/PRMT1/INSR/RAF1/MAP2K2/MAPK3/CAT/ARAF/STK11	2.23334404932498
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/359	32/9376	3.26462395543175	ECHDC1/SUCLA2/ECHS1/DLD	2.56039222037256
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/359	19/9376	4.12373552265064	DLST/PDHB/DLD	2.71947186291638
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/359	155/9376	1.85346392308384	C1R/RAB7A/HLA-DMA/SEC22B/M6PR/ATP6V1E1/PIK3C3/HLA-DRB5/HLA-DPA1/CTSS/ATP6V1D	2.13778405468905
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/359	33/9376	3.16569595678231	DLST/BCAT1/PDHB/DLD	2.48664110783994
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/359	33/9376	3.16569595678231	SNAP23/GOSR2/SEC22B/STX5	2.48664110783994
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/359	65/9376	2.41079922862653	CGA/TRPC4/RAF1/MAP2K2/MAPK3/SPP1	2.27732784431833
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/359	138/9376	1.89253562633725	MT-CO3/SDHC/NDUFA5/ATP6V1E1/NDUFB1/NDUFA8/NDUFS2/ATP6V1D/NDUFB5/ATP5ME	2.10755031809602
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/359	50/9376	2.6116991643454	SAT1/SRM/SAT2/CKB/LAP3	2.27993835654364
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/359	50/9376	2.6116991643454	CXCL12/IL15/HLA-DMA/HLA-DRB5/HLA-DPA1	2.27993835654364
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/359	68/9376	2.3044404391283	TCF7L2/RAF1/PPARD/MAP2K2/MAPK3/ARAF	2.15403299113278
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/359	105/9376	1.98986602997745	JUN/MAP1LC3B/RAB7A/UBC/SAMM50/MFN1/TBC1D15/SIAH1	2.03521177724696
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/359	87/9376	2.10136714372619	JUN/TCF7L2/POLK/RAF1/MAP2K2/MAPK3/ARAF	2.05925006741254
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/359	205/9376	1.6561994700727	COL3A1/COL1A1/COL1A2/MT-CO3/SLC25A6/INSR/SDHC/NDUFA5/NDUFB1/NDUFA8/NDUFS2/PDHB/NDUFB5	1.89542361327532
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/359	38/9376	2.74915701510043	GPI/PMM1/UXS1/NAGK	2.15573556812561
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/359	109/9376	1.91684342337277	JUN/CXCL8/STAT2/CCL4L2/MAP2K2/CCL5/MAPK3/SPP1	1.92105884952193
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/359	73/9376	2.14660205288663	POLK/RAF1/MAP2K2/MAPK3/FGF10/ARAF	1.96229574544978
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/359	93/9376	1.9657950699374	JUN/EGR1/CGA/RAF1/MAP2K2/MAPK3/MAP3K4	1.86760105608785
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/359	93/9376	1.9657950699374	COL4A1/COL4A2/FN1/LAMA2/MAX/XIAP/POLK	1.86760105608785
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/359	173/9376	1.66061796576875	CXCL8/SLC25A6/HLA-DMA/STAT2/RAF1/HLA-DRB5/MAP2K2/CCL5/RAB11B/HLA-DPA1/MAPK3	1.74988919097129
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	20/359	368/9376	1.41940171975294	MAP1LC3B/MT-CO3/SDHC/NDUFA5/NDUFB1/PIK3C3/NDUFA8/DCTN2/SEC13/CCS/ATXN2/PSMC4/NDUFS2/PSMB6/CAT/NDUFB5/PSMD3/PSMB4/PSMC5/GPX3	1.63772792845953
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/359	196/9376	1.59899948837474	JUN/MAP1LC3B/TCF7L2/UBC/GNG4/CXCL8/STAT2/PIK3C3/RAF1/MAP2K2/MAPK3/ANGPT2	1.6909663846165
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/359	77/9376	2.03509025793148	CTBP1/POLK/RAF1/MAP2K2/MAPK3/ARAF	1.81973139357181
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/359	42/9376	2.48733253747181	DLST/ECHS1/CAT/DLD	1.92752781324335
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/359	78/9376	2.00899935718877	JUN/C1R/C1S/CXCL8/C1QB/MAPK3	1.78543994817137
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/359	78/9376	2.00899935718877	EEF1A1/JUN/HLA-DMA/HLA-DRB5/HLA-DPA1/MAPK3	1.78543994817137
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/359	60/9376	2.17641597028784	PRKG1/RAF1/MAP2K2/MAPK3/ARAF	1.82399492023098
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/359	158/9376	1.65297415464899	RPS6/INSR/ATP6V1E1/RAF1/MAP2K2/MAPK3/SEC13/EIF4E2/ATP6V1D/STK11	1.6516119293247
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/359	27/9376	2.90188796038378	HSD17B12/SCP2/ACOT2	1.97463149225879
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/359	99/9376	1.84665597478968	CFD/C1R/C1S/HLA-DMA/HLA-DRB5/C1QB/HLA-DPA1	1.68975065771378
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/359	80/9376	1.95877437325905	RPS6/RAF1/MAP2K2/MAPK3/EIF4E2/ARAF	1.71836406117626
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/359	140/9376	1.67894946279347	EGR1/MAP1LC3B/RPS6/GNG4/PIK3C3/RAF1/MAP2K2/MAPK3/SPP1	1.61495837267978
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/359	224/9376	1.51571826502189	JUN/EGR1/IL15/IL1R1/SLC25A6/XIAP/HLA-DMA/HLA-DRB5/MAP2K2/HLA-DPA1/MAPK3/CREB3/CREB3L2	1.55876391718652
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/359	28/9376	2.79824910465579	HSD17B12/ECHS1/ACOT2	1.9013906072909
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/359	63/9376	2.07277711455984	SMYD2/DLST/ECHS1/DLD/CAMKMT	1.70465619487475
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/359	63/9376	2.07277711455984	GTF2H3/POLR2H/ERCC1/ERCC8/POLR2M	1.70465619487475
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/359	122/9376	1.7125896159642	EEF2/FOXO1/INSR/RAB11B/SREBF1/CREB3/CREB3L2/STK11	1.58072559282885
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/359	250/9376	1.46255153203343	RAB7A/WASHC2C/VPS25/ZFYVE16/RAB4A/RAB11B/RUFY1/STAM2/CHMP1B/MVB12A/EHD1/CHMP4B/SNX12/CAV1	1.47908020057762
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/359	144/9376	1.63231197771588	RORA/SLC25A6/PIK3C3/ATXN2/PSMC4/PSMB6/PSMD3/PSMB4/PSMC5	1.52569100020245
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/359	253/9376	1.44520902374844	JUN/MAP1LC3B/IL1R1/FOXO1/UBC/CXCL8/BCL10/PIK3C3/CCL5/MAPK3/CAPNS1/RBCK1/CASP4/UBE2D1	1.43237657207628
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/359	66/9376	1.97855997298894	JUN/RORA/HLA-DMA/HLA-DRB5/HLA-DPA1	1.5917923102193
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/359	48/9376	2.17641597028784	AUH/BCAT1/ECHS1/DLD	1.63038093869861
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/359	86/9376	1.82211569605493	JUN/PAK3/RAF1/MAP2K2/MAPK3/ARAF	1.52818571679633
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	16/359	300/9376	1.39290622098422	JUN/HSPB1/CACNB2/IL1R1/PPM1A/MAX/RASA1/INSR/RAF1/MAP2K2/MAPK3/MKNK2/FGF10/MAP3K4/ARAF/ANGPT2	1.38007953732903
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/359	31/9376	2.52745080420523	GPI/TALDO1/H6PD	1.69965295315129
Human Diseases	Immune disease	hsa05310	Asthma	3/359	32/9376	2.44846796657382	HLA-DMA/HLA-DRB5/HLA-DPA1	1.63764324058269
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/359	109/9376	1.67723799545118	JUN/RORA/IL1R1/HLA-DMA/HLA-DRB5/HLA-DPA1/MAPK3	1.41901442626699
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/359	109/9376	1.67723799545118	FOXO1/INSR/NR1H2/SREBF1/CREB3/MLXIP/CREB3L2	1.41901442626699
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/359	110/9376	1.66199037731071	THSD4/DCN/ID4/FBN1/ZFYVE16/MAPK3/BMP8A	1.39348949436833
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/359	70/9376	1.86549940310386	LAMA2/HLA-DMA/HLA-DRB5/HLA-DPA1/CAV1	1.45022736663395
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/359	71/9376	1.83922476362352	CGA/RAF1/MAP2K2/MAPK3/SOCS2	1.41628646155383
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/359	71/9376	1.83922476362352	JUN/CXCL8/ATP6V1E1/CCL5/ATP6V1D	1.41628646155383
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/359	17/9376	3.07258725217106	SCP2/CYP7B1	1.70657110212349
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/359	34/9376	2.3044404391283	POLR2H/POLR3A/POLR2M	1.52035710723483
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/359	134/9376	1.55922338169875	MYL6/CALD1/PRKG1/RAF1/MAP2K2/MAPK3/PPP1R12C/ARAF	1.30093790016326
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/359	73/9376	1.78883504407219	POLK/RAF1/MAP2K2/MAPK3/ARAF	1.35001297699369
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/359	54/9376	1.93459197358919	CGA/HLA-DMA/HLA-DRB5/HLA-DPA1	1.37425145415974
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/359	115/9376	1.58972992612329	NACA/EGR1/RAF1/MAPK3/CREB3/ARAF/CREB3L2	1.26962355899687
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/359	181/9376	1.44292771510796	RAB7A/HLA-DMA/BCL10/PIK3C3/RAF1/HLA-DRB5/HLA-DPA1/MAPK3/CTSS/CD74	1.20059935122815
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/359	55/9376	1.89941757406938	PSAP/CERS2/SAMD8/CERK	1.33479105491838
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/359	205/9376	1.40139955159997	VIM/JUN/HLA-DMA/STAT2/POLK/HLA-DRB5/HLA-DPA1/CIR1/PSMC4/PSMD3/PSMC5	1.15943737104272
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/359	76/9376	1.71822313443777	POLK/RAF1/MAP2K2/MAPK3/ARAF	1.25437254381244
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/359	56/9376	1.86549940310386	EEF1A1/EEF1G/CXCL8/SEC22B	1.29614818985917
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/359	119/9376	1.53629362608553	JUN/IL15/XIAP/CCL5/MAPK3/CREB3/CREB3L2	1.17474285389008
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/359	163/9376	1.4420424833809	JUN/CXCL8/STAT2/RAF1/MAP2K2/MAPK3/CREB3/ARAF/CREB3L2	1.13594970833314
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/359	57/9376	1.83277134340028	CBR4/HSD17B12/SCP2/ECHS1	1.25828891833498
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/359	142/9376	1.47137981089882	UBC/XIAP/UBE2J2/UBA1/SIAH1/ERCC8/PIAS2/UBE2D1	1.12933306195449
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/359	232/9376	1.35087887810969	CXCL12/ITGB8/FN1/PAK3/GSN/TMSB4X/RAF1/MAP2K2/MAPK3/PPP1R12C/FGF10/ARAF	1.07977914983323
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/359	39/9376	2.00899935718877	HLA-DMA/HLA-DRB5/HLA-DPA1	1.2598572552104
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/359	122/9376	1.49851591396867	CSH1/RAF1/MAP2K2/MAPK3/CREB3/SOCS2/CREB3L2	1.10584949035005
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/359	101/9376	1.55150445406658	TCF7L2/RAF1/MAP2K2/MAPK3/CREB3/CREB3L2	1.11187145213907
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/359	60/9376	1.74113277623027	HSPB1/RAF1/MAP2K2/MAPK3	1.14910240357409
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/359	169/9376	1.390845708823	MAP1LC3B/RAB7A/UBC/PIK3C3/RAF1/MAP2K2/MAPK3/EIF2AK4/STK11	1.02303727194116
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/359	82/9376	1.59249949045451	HLA-DMA/HLA-DRB5/HLA-DPA1/CTSS/CD74	1.07521521415625
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/359	148/9376	1.41172927802454	JUN/TCF7L2/POLK/RAF1/MAP2K2/MAPK3/FGF10/ARAF	1.00737378077524
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/359	62/9376	1.68496720280349	SOD2/FOXO1/INSR/CAT	1.07969063138524
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/359	105/9376	1.49239952248309	CXCL12/IL1R1/CXCL8/XIAP/BCL10/CCL4L2	1.01239690717661
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/359	44/9376	1.78070397569005	GTF2H3/TAF9/TAF13	1.03568382072005
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/359	44/9376	1.78070397569005	HLA-DMA/HLA-DRB5/HLA-DPA1	1.03568382072005
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/359	154/9376	1.35672683862099	JUN/CACNB2/EEF2/MYL6/RAF1/MAP2K2/MAPK3/PPP1R12C	0.890605584811479
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/359	178/9376	1.32052204938813	SFRP2/JUN/APCDD1/TCF7L2/MCC/CTBP1/PPARD/SIAH1/SERPINF1	0.861436039341007
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/359	155/9376	1.34797376224279	PBX1/TCF7L2/MAP2K2/MAPK3/CREB3/ARNT/AIP/CREB3L2	0.871615940934998
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/359	45/9376	1.74113277623027	HLA-DMA/HLA-DRB5/HLA-DPA1	0.994351675746169
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	11/359	227/9376	1.2655810928546	CXCL12/IL1R1/GNG4/CXCL8/CCL4L2/RAF1/MAP2K2/CCL5/MAPK3/CREB3/CREB3L2	0.808211631049137
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/359	157/9376	1.33080212195944	PBX1/RAB7A/PPARD/C1QB/NR1H2/MAP2K2/MAPK3/ARNT	0.834023010867893
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/359	67/9376	1.55922338169875	RAF1/MAP2K2/MAPK3/ARAF	0.916585611131069
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/359	112/9376	1.3991245523279	LAMA2/XIAP/HLA-DMA/HLA-DRB5/HLA-DPA1/MAPK3	0.84785192436902
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/359	47/9376	1.66704201979494	INSR/MAPK3/SOCS2	0.914716267855809
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/359	91/9376	1.43499954084912	JUN/BCL10/RAF1/MAP2K2/MAPK3	0.831994333289075
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/359	137/9376	1.33444482849765	JUN/XIAP/RAF1/MAP2K2/MAPK3/CTSS/DFFA	0.786817684484835
NA	NA	hsa03272	Virion - Hepatitis viruses	3/359	48/9376	1.63231197771588	CHMP1B/CHMP4B/TGOLN2	0.876313669497833
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/359	93/9376	1.40413933566957	JUN/HLA-DMA/HLA-DRB5/HLA-DPA1/MAPK3	0.781502280967388
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/359	71/9376	1.47137981089882	RAF1/MAP2K2/MAPK3/PDHB	0.795506607244599
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/359	49/9376	1.59899948837474	JUN/CREB3/CREB3L2	0.838794029912882
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/359	28/9376	1.86549940310386	ATP6V1E1/ATP6V1D	0.915141529289159
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/359	166/9376	1.25865019968453	SLC25A6/INSR/PRKG1/RAF1/MAP2K2/MAPK3/CREB3/CREB3L2	0.670870777153938
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/359	168/9376	1.24366626873591	FTL/FTH1/SLC25A6/XIAP/STAT2/CHMP1B/RBCK1/CHMP4B	0.63587130383272
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/359	217/9376	1.20354800200249	JUN/XIAP/RAF1/MAP2K2/MAPK3/FGF10/CREB3/ARNT/AIP/CREB3L2	0.605305344960336
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/359	193/9376	1.21789080202635	CXCL12/GNG4/CXCL8/STAT2/CCL4L2/RAF1/CXCL14/CCL5/MAPK3	0.610277119162289
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/359	52/9376	1.50674951789158	CGA/INSR/ACOT2	0.73113186333768
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/359	75/9376	1.39290622098422	REV3L/XIAP/MAPK3/ERCC1	0.681642314352734
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/359	75/9376	1.39290622098422	CGA/CREB3/CREB3L2/GPX3	0.681642314352734
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/359	122/9376	1.28444221197315	JUN/PAK3/BCL10/RAF1/MAP2K2/MAPK3	0.630973387871253
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/359	99/9376	1.31903998199263	JUN/RAF1/MAP2K2/MAPK3/ARAF	0.636737985039268
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/359	99/9376	1.31903998199263	JUN/PCYT1A/RAF1/MAP2K2/MAPK3	0.636737985039268
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/359	76/9376	1.37457850755021	PLIN2/UBC/PPARD/SCP2	0.654199193598854
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/359	31/9376	1.68496720280349	CAT/DLD	0.762189214769827
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/359	100/9376	1.3058495821727	CXCL12/CXCL8/CCL4L2/CXCL14/CCL5	0.613520882139636
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/359	77/9376	1.35672683862099	POLK/RAF1/MAPK3/ARAF	0.627140505085507
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/359	54/9376	1.45094398019189	REV3L/POLK/ERCC1	0.663081256886216
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/359	149/9376	1.22697276177301	GNG4/NDUFA5/NDUFB1/NDUFA8/MAPK3/NDUFS2/NDUFB5	0.557235073101456
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/359	174/9376	1.20078122498639	DNAJA2/UBXN2A/UBE2J2/NPLOC4/SEL1L/SEC13/MBTPS1/UBE2D1	0.533406663699773
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/359	78/9376	1.33933290479251	INPP4B/PI4KB/PIK3C3/IPMK	0.600454816575506
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/359	150/9376	1.21879294336119	TCF7L2/POLK/RAF1/MAP2K2/MAPK3/FGF10/ARAF	0.538981728464633
Organismal Systems	Immune system	hsa04611	Platelet activation	6/359	126/9376	1.24366626873591	COL3A1/COL1A1/COL1A2/SNAP23/PRKG1/MAPK3	0.549429086258847
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/359	103/9376	1.26781512832301	JUN/CXCL8/C1QB/CCL5/MAPK3	0.545312453420976
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/359	201/9376	1.16941753627406	DDX5/PBX1/NFKBIZ/ZEB1/FOXO1/MAX/CXCL8/BMP2K/POLK	0.484456940003539
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/359	105/9376	1.24366626873591	JUN/STAT2/BCL10/RAF1/MAPK3	0.500989472141435
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/359	34/9376	1.53629362608553	RORB/RORA	0.625063285011882
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/359	180/9376	1.16075518415351	HLA-DMA/STAT2/SRSF6/HLA-DRB5/CCL5/HLA-DPA1/SRSF8/CD74	0.434513812148068
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/359	107/9376	1.22042017025486	FOXO1/PRMT1/CREB3/PDHB/CREB3L2	0.45753951651459
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/359	83/9376	1.25865019968453	MAX/PCGF3/PCGF5/UBE2D1	0.472254085040028
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/359	83/9376	1.25865019968453	SOD2/SCP2/CAT/SLC25A17	0.472254085040028
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/359	83/9376	1.25865019968453	CCL4L2/POLR2H/CCL5/POLR3A	0.472254085040028
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/359	59/9376	1.32798262593834	SRM/LAP3/GPX3	0.504243866636718
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/359	59/9376	1.32798262593834	CGA/INSR/PRKG1	0.504243866636718
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/359	157/9376	1.16445185671451	FOXO1/CXCL8/SLC25A6/RAF1/MAP2K2/MAPK3/RAD50	0.414618358151489
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/359	108/9376	1.20911998349324	EEF1A1/THOC7/NMD3/SEC13/PHAX	0.436130268480289
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/359	13/9376	2.00899935718877	RAD50	0.726368298535421
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/359	160/9376	1.14261838440111	VCAN/ITGB8/NLGN1/CADM1/HLA-DMA/HLA-DRB5/HLA-DPA1	0.363049713472207
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/359	86/9376	1.21474379736996	CACNB2/ITGB8/TCF7L2/LAMA2	0.399175451200051
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/359	238/9376	1.09735259006109	PAK3/GNG4/RASA1/INSR/RALGAPA2/RAF1/MAP2K2/MAPK3/FGF10/ANGPT2	0.30353742091686
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/359	38/9376	1.37457850755021	INSR/MAPK3	0.461646498747879
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/359	88/9376	1.18713598379337	CFD/C1R/C1S/C1QB	0.351916285527567
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/359	139/9376	1.1273521572714	JUN/RAF1/MAP2K2/MAPK3/CREB3/CREB3L2	0.30182142277645
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/359	15/9376	1.74113277623027	ST6GALNAC6	0.573168552969808
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/359	15/9376	1.74113277623027	TPK1	0.573168552969808
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/359	89/9376	1.17379737723389	PRKG1/RAF1/MAP2K2/MAPK3	0.328701984770454
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/359	90/9376	1.16075518415351	JUN/RAF1/MAP2K2/MAPK3	0.305755114203075
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/359	65/9376	1.20539961431326	PBX1/CREB3/CREB3L2	0.331558347493021
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/359	168/9376	1.08820798514392	IL15/CSH1/STAT2/RAF1/STAM2/PIAS2/SOCS2	0.230187488867043
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/359	143/9376	1.09581783119388	C1R/C1S/HLA-DMA/HLA-DRB5/C1QB/HLA-DPA1	0.230379995320536
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/359	144/9376	1.08820798514392	ID4/RAF1/MAP2K2/MAPK3/PCGF3/PCGF5	0.212835014712529
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/359	67/9376	1.16941753627406	GPI/PDHB/DLD	0.277680943079259
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/359	170/9376	1.07540553825987	TCF7L2/SMARCC2/POLK/RAF1/MAP2K2/MAPK3/ARAF	0.197967567800162
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/359	93/9376	1.12331146853566	TCF7L2/INSR/KRIT1/MAPK3	0.238452893407155
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/359	250/9376	1.04467966573816	RAB7A/DMXL1/M6PR/PSAP/ATP6V1E1/AP1G1/CTSS/ATP6V1D/AP3S2/SNAPIN	0.142870154750596
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/359	69/9376	1.13552137580235	RAF1/MAP2K2/MAPK3	0.225439139462339
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/359	69/9376	1.13552137580235	JUN/CREB3/CREB3L2	0.225439139462339
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/359	18/9376	1.45094398019189	CBR4	0.382093063438088
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/359	149/9376	1.05169093866258	CXCL8/INSR/RAF1/AGPAT3/MAP2K2/MAPK3	0.126905113015858
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/359	98/9376	1.06599965891649	INPP4B/PI4KB/PIK3C3/IPMK	0.131047690775799
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/359	98/9376	1.06599965891649	MARCKS/GSN/RAF1/MAPK3	0.131047690775799
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/359	99/9376	1.0552319855941	CACNB2/ITGB8/TPM2/LAMA2	0.110231648702009
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/359	46/9376	1.13552137580235	FTL/FTH1	0.183843264662195
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/359	100/9376	1.04467966573816	IL1R1/HLA-DMA/HLA-DRB5/HLA-DPA1	0.0896254549136592
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/359	47/9376	1.11136134652996	PDHB/DLD	0.152710072616709
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/359	20/9376	1.3058495821727	CMAS	0.273199317741526
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/359	21/9376	1.24366626873591	DSE	0.223041148175964
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/359	21/9376	1.24366626873591	BCAT1	0.223041148175964
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/359	184/9376	0.993581203827056	SEMA5A/CXCL12/PAK3/TRPC4/RASA1/RAF1/MAPK3	-0.0175452401231331
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/359	104/9376	1.00449967859439	PCYT1A/AGPAT3/LPGAT1/SAMD8	0.009206896895292
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/359	105/9376	0.994933014988725	CACNB2/ITGB8/TPM2/LAMA2	-0.0104179628937415
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/359	50/9376	1.04467966573816	CXCL8/HBB	0.0632046512944349
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/359	51/9376	1.02419575072369	ATP6V1E1/ATP6V1D	0.0345701765114407
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/359	79/9376	0.991784492789394	ATP6V1E1/ATP6V1D/NSF	-0.014631145829595
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/359	243/9376	0.967295986794594	DDX5/ZMAT2/SRSF6/THOC7/BUD31/SYF2/PLRG1/SRSF8/DDX42	-0.103062170642141
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/359	23/9376	1.13552137580235	B3GALNT2	0.129836882881686
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/359	23/9376	1.13552137580235	FNTA	0.129836882881686
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/359	24/9376	1.08820798514392	EXT2	0.0863302704455834
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/359	138/9376	0.946267813168625	JUN/FN1/CXCL8/MAP2K2/MAPK3	-0.126878170581474
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/359	54/9376	0.967295986794594	SRM/BCAT1	-0.0480889403873096
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/359	226/9376	0.924495279414302	JUN/CGA/RAF1/MAP2K2/MAPK3/CREB3/PDE10A/CREB3L2	-0.229255416299854
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/359	115/9376	0.90841710064188	GNG4/MAPK3/CREB3/CREB3L2	-0.197167892412502
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/359	115/9376	0.90841710064188	GNG4/RAF1/MAPK3/ARAF	-0.197167892412502
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/359	200/9376	0.914094707520891	JUN/PAK3/IL1R1/RPS3/CXCL8/MAPK3/CASP4	-0.245024800259781
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/359	144/9376	0.906839987619932	TCF7L2/FOXO1/CXCL8/C1QB/SREBF1	-0.224783647117444
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/359	27/9376	0.967295986794594	ECHS1	-0.0339548783860069
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/359	87/9376	0.900585918739794	CACNB2/TPM2/MT-CO3	-0.185876666743683
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/359	89/9376	0.880348032925417	GNG4/PLCL1/NSF	-0.22629708045695
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/359	120/9376	0.870566388115135	JUN/RAF1/MAP2K2/MAPK3	-0.284726472846235
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/359	61/9376	0.8562948079821	FTL/FTH1	-0.22467139137166
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/359	122/9376	0.8562948079821	FOXO1/RAF1/MAP2K2/MAPK3	-0.318778817086343
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/359	62/9376	0.842483601401743	CTBP1/CIR1	-0.248287770801303
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/359	63/9376	0.829110845823938	PTGDS/PTGES2	-0.271544994155336
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/359	63/9376	0.829110845823938	TCF7L2/POLK	-0.271544994155336
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/359	31/9376	0.842483601401743	ECHS1	-0.175274523611637
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/359	94/9376	0.833521009897469	JUN/CXCL8/MAPK3	-0.323671458720738
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/359	183/9376	0.8562948079821	EMG1/TCOF1/GNL3L/NMD3/IMP4/RIOK2	-0.391715901429497
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/359	154/9376	0.847954274138118	CACNB2/TPM2/MAPK3/CREB3/CREB3L2	-0.379597938643408
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/359	212/9376	0.862353497661218	INSR/RAF1/MAP2K2/KRIT1/MAPK3/FGF10/ANGPT2	-0.404475665370357
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/359	125/9376	0.835743732590529	RAF1/MAP2K2/MAPK3/CERS2	-0.368879434382483
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/359	32/9376	0.816155988857939	PIK3C3	-0.207854718997034
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/359	32/9376	0.816155988857939	XIAP	-0.207854718997034
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/359	214/9376	0.854294119178403	JUN/PAK3/GNG4/RAF1/MAP2K2/MAPK3/AP1G1	-0.43022005479572
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/359	156/9376	0.837083065495322	STAT2/RAF1/MAP2K2/MAPK3/ARAF	-0.40941608019036
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/359	97/9376	0.807742009591362	GNG4/PRKG1/MAPK3	-0.379770744459112
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/359	66/9376	0.791423989195577	HSD17B12/CYP7B1	-0.33928394708461
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/359	191/9376	0.82042905686243	GNG4/RAF1/MAPK3/CREB3/ARAF/CREB3L2	-0.500282135035298
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/359	35/9376	0.746199761241544	PMM1	-0.300145053280147
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/359	133/9376	0.785473432885836	RAF1/MAP2K2/MAPK3/ARAF	-0.497166954930907
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/359	36/9376	0.725471990095946	GPI	-0.329280719264092
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/359	36/9376	0.725471990095946	GALNT13	-0.329280719264092
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/359	37/9376	0.705864639012271	GSTZ1	-0.357684186904875
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/359	37/9376	0.705864639012271	HBB	-0.357684186904875
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/359	72/9376	0.725471990095946	CXCL8/OTUD5	-0.466573304805601
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/359	136/9376	0.768146813042766	JUN/RACK1/STAT2/RAB9A	-0.543435951439026
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/359	39/9376	0.669666452396257	DLD	-0.412461230646854
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/359	75/9376	0.696453110492108	TALDO1/BCAT1	-0.526615241062945
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/359	75/9376	0.696453110492108	SHISA5/SIAH1	-0.526615241062945
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/359	110/9376	0.712281590276019	RAF1/MAPK3/ARAF	-0.605647143868599
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/359	142/9376	0.73568990544941	JUN/IL1R1/STAT2/MAPK3	-0.633234859624419
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/359	142/9376	0.73568990544941	JUN/IL1R1/TXN/CAV1	-0.633234859624419
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/359	41/9376	0.636999796181806	DLD	-0.464775753637352
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/359	41/9376	0.636999796181806	RAD50	-0.464775753637352
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/359	205/9376	0.764399755418167	JUN/GSN/GTF2H3/MAPK3/CREB3/CREB3L2	-0.680528234538769
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/359	78/9376	0.669666452396257	FN1/CAV1	-0.584530315020357
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/359	298/9376	0.788768203996934	CXCL12/IL15/IL1R1/CXCL8/CSH1/CCL4L2/CXCL14/CCL5/BMP8A	-0.739391003710677
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/359	43/9376	0.607371898684978	ECHS1	-0.514880924686675
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/359	44/9376	0.593567991896683	APTX	-0.539173704915887
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/359	45/9376	0.580377592076756	ABCB8	-0.562992567433666
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/359	154/9376	0.678363419310494	BCAT1/PMM1/DLD/TPK1	-0.80299911312837
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/359	86/9376	0.607371898684978	CREB3/CREB3L2	-0.729834814396232
NA	NA	hsa04081	Hormone signaling	6/359	219/9376	0.715534017628878	CGA/GNG4/INSR/CSH1/PRKG1/STK11	-0.849919154673577
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/359	49/9376	0.532999829458246	GALNT13	-0.653952069444275
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/359	91/9376	0.573999816339649	GNG4/PDE10A	-0.814781868720291
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/359	52/9376	0.502249839297193	APOE	-0.718147703396799
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/359	195/9376	0.669666452396257	SLC25A6/RAF1/MAP2K2/MAPK3/CASP4	-0.930093953612395
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/359	93/9376	0.561655734267829	CST3/PRKG1	-0.847645881713312
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/359	133/9376	0.589105074664377	GNG4/CREB3/CREB3L2	-0.952252122306889
NA	NA	hsa04517	IgSF CAM signaling	8/359	299/9376	0.698782385109138	PAK3/NLGN1/FOXO1/MYL6/RASA1/CADM1/MAP2K2/MAPK3	-1.05620110970955
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/359	98/9376	0.532999829458246	CREB3/CREB3L2	-0.927266821467
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/359	170/9376	0.614517450434213	JUN/MYL6/RAB13/STK11	-1.0120349848037
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/359	216/9376	0.604559991746621	JUN/SOD2/CXCL8/CCL5/MAPK3	-1.17317168596716
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/359	65/9376	0.401799871437754	AGPAT3	-0.965621317057185
NA	NA	hsa04382	Cornified envelope formation	5/359	217/9376	0.601774001001245	S100A6/S100A4/COL4A1/COL4A2/DST	-1.18423331756981
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/359	68/9376	0.384073406521383	ALDH1A3	-1.01708453883534
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/359	323/9376	0.646860474141277	VIM/TIMP3/MARCKS/ZEB1/RAF1/MAP2K2/MAPK3/TNXB	-1.28870394564793
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/359	70/9376	0.373099880620772	STK11	-1.05043135328511
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/359	116/9376	0.450292959369897	GNG4/MAPK3	-1.18865720825549
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/359	117/9376	0.446444301597505	SMARCC2/INO80D	-1.20219257766733
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/359	73/9376	0.357767008814439	CHMP4B	-1.09911809683069
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/359	78/9376	0.334833226198129	EXOSC7	-1.17702288081829
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/359	99/9376	0.263807996398526	IL1R1	-1.46928736030977
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/359	194/9376	0.403871004795681	TPM2/MYL6/DCTN2	-1.67407262395466
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/359	157/9376	0.33270053048986	TCF7L2/BMP8A	-1.68240490543054
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/359	116/9376	0.225146479684949	CXCL12	-1.6755019568403
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/359	128/9376	0.204038997214485	PDE10A	-1.80915048284164
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/359	138/9376	0.189253562633725	MAPK3	-1.91442096152347
NA	NA	hsa04519	Cadherin signaling	6/359	404/9376	0.387876113516644	VIM/TCF7L2/CDH11/RAF1/MAP2K2/MAPK3	-2.50950002735296
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/359	254/9376	0.205645603491764	SLC25A6/FGF10	-2.56087249472942
NA	NA	hsa04082	Neuroactive ligand signaling	1/359	199/9376	0.131241164037457	GNG4	-2.47159458324446
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/359	370/9376	0.141172927802454	CGA/CSH1	-3.36312062407751
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/359	449/9376	0.0581670192504544	PRKG1	-4.08080765407374