ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 61/653 175/18639 0.348571428571429 9.94949901553271 2.2856557133047e-44 1.87195202919655e-41 GO:0019843 rRNA binding 25/653 65/18639 0.384615384615385 10.9783248910355 4.55339527957257e-20 1.86461536698497e-17 GO:0005201 extracellular matrix structural constituent 25/653 168/18639 0.148809523809524 4.24756617807919 9.90002076217198e-10 2.70270566807295e-07 GO:0045296 cadherin binding 34/653 334/18639 0.101796407185629 2.90564048014232 2.72679706661307e-08 5.58311699389027e-06 GO:1990948 ubiquitin ligase inhibitor activity 6/653 11/18639 0.545454545454545 15.5692607545594 7.18455005317077e-07 0.000117682929870937 GO:0005518 collagen binding 13/653 72/18639 0.180555555555556 5.15371362940276 1.12476533765427e-06 0.000153530468589807 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/653 15/18639 0.4 11.4174578866769 6.90052557432556e-06 0.000807361492196091 GO:0004857 enzyme inhibitor activity 33/653 416/18639 0.0793269230769231 2.26427950877606 1.16325355423036e-05 0.00119088082614334 GO:0030020 extracellular matrix structural constituent conferring tensile strength 9/653 44/18639 0.204545454545455 5.83847278295977 1.77763230268532e-05 0.00161764539544365 GO:0048407 platelet-derived growth factor binding 5/653 11/18639 0.454545454545455 12.9743839621328 2.01461002472791e-05 0.00164996561025216 GO:0005520 insulin-like growth factor binding 6/653 19/18639 0.315789473684211 9.01378254211332 3.31751718733474e-05 0.0024700423422065 GO:0031994 insulin-like growth factor I binding 5/653 13/18639 0.384615384615385 10.9783248910355 5.29325698399966e-05 0.00361264789157977 GO:0019838 growth factor binding 15/653 136/18639 0.110294117647059 3.1481961084587 8.57844648139944e-05 0.00540442128328165 GO:0000049 tRNA binding 11/653 80/18639 0.1375 3.92475114854518 0.000104461774695744 0.00580539255937532 GO:0050840 extracellular matrix binding 10/653 67/18639 0.149253731343284 4.26024548010331 0.00010632587105083 0.00580539255937532 GO:0048027 mRNA 5'-UTR binding 6/653 24/18639 0.25 7.13591117917305 0.000141700708531248 0.00725330501794327 GO:0055106 ubiquitin-protein transferase regulator activity 7/653 36/18639 0.194444444444444 5.55015313935681 0.000215820394263837 0.0103974648765931 GO:1901681 sulfur compound binding 22/653 275/18639 0.08 2.28349157733538 0.000289681453215411 0.0131805061213012 GO:0001968 fibronectin binding 6/653 30/18639 0.2 5.70872894333844 0.000522711837442131 0.0225316313086897 GO:0008135 translation factor activity, RNA binding 10/653 83/18639 0.120481927710843 3.4389933393605 0.000631771053806715 0.025871024653385 GO:0180051 translation factor activity 10/653 84/18639 0.119047619047619 3.39805294246336 0.000695091984351483 0.0271085873897078 GO:0005539 glycosaminoglycan binding 19/653 242/18639 0.0785123966942149 2.24102995709567 0.000918274852719043 0.034184868380768 GO:0008201 heparin binding 15/653 172/18639 0.0872093023255814 2.48927134157199 0.00108796270540749 0.0387409328577709 GO:0061134 peptidase regulator activity 17/653 226/18639 0.0752212389380531 2.1470883193972 0.00262576732745829 0.0896043100495142 GO:0002020 protease binding 12/653 136/18639 0.0882352941176471 2.51855688676696 0.0030073114379946 0.0950456223889213 GO:0003746 translation elongation factor activity 4/653 18/18639 0.222222222222222 6.34303215926493 0.00308571750261001 0.0950456223889213 GO:0016209 antioxidant activity 9/653 86/18639 0.104651162790698 2.98712560988639 0.00313337216666774 0.0950456223889213 GO:0140297 DNA-binding transcription factor binding 29/653 488/18639 0.0594262295081967 1.69624118193458 0.00410476489012285 0.120064373036093 GO:1905394 retromer complex binding 3/653 10/18639 0.3 8.56309341500766 0.00427143722093607 0.120631278756781 GO:0005178 integrin binding 13/653 161/18639 0.0807453416149068 2.30476634358384 0.00443578447920514 0.1210969162823 GO:0097493 structural molecule activity conferring elasticity 3/653 11/18639 0.272727272727273 7.78463037727969 0.00572150355271326 0.15115843257007 GO:0004859 phospholipase inhibitor activity 3/653 12/18639 0.25 7.13591117917305 0.0074319646127638 0.190211844307923 GO:0140102 catalytic activity, acting on a rRNA 4/653 23/18639 0.173913043478261 4.96411212464212 0.00777438631241736 0.192946133026358 GO:0003743 translation initiation factor activity 6/653 51/18639 0.117647058823529 3.35807584902261 0.00852822967596986 0.205430003077039 GO:0051117 ATPase binding 8/653 84/18639 0.0952380952380952 2.71844235397068 0.00915415350138938 0.214207191932511 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 7/653 68/18639 0.102941176470588 2.93831636789478 0.00957029664310314 0.217724248630596 GO:0044389 ubiquitin-like protein ligase binding 20/653 322/18639 0.062111801242236 1.77289718737219 0.00992156996371124 0.219615291899446 GO:0031625 ubiquitin protein ligase binding 19/653 302/18639 0.0629139072847682 1.79579221727534 0.0103667968957825 0.223431754148575 GO:0008191 metalloendopeptidase inhibitor activity 3/653 14/18639 0.214285714285714 6.11649529643404 0.0116722915179141 0.243955416574991 GO:0008198 ferrous iron binding 4/653 26/18639 0.153846153846154 4.39132995641418 0.0120841497769962 0.243955416574991 GO:0140313 molecular sequestering activity 6/653 55/18639 0.109090909090909 3.11385215091188 0.012212664321825 0.243955416574991 GO:0015078 proton transmembrane transporter activity 13/653 185/18639 0.0702702702702703 2.00576962874053 0.0135722486789064 0.251181935887415 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/653 41/18639 0.121951219512195 3.48093228252344 0.0137420431227429 0.251181935887415 GO:0001671 ATPase activator activity 4/653 27/18639 0.148148148148148 4.22868810617662 0.0138012052685393 0.251181935887415 GO:0023026 MHC class II protein complex binding 4/653 27/18639 0.148148148148148 4.22868810617662 0.0138012052685393 0.251181935887415 GO:0004601 peroxidase activity 6/653 57/18639 0.105263157894737 3.00459418070444 0.0144211855553701 0.251296829145705 GO:0016504 peptidase activator activity 6/653 57/18639 0.105263157894737 3.00459418070444 0.0144211855553701 0.251296829145705 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/653 58/18639 0.103448275862069 2.95279083276126 0.0156234020327233 0.263457896062815 GO:0004879 nuclear receptor activity 6/653 59/18639 0.101694915254237 2.90274353051107 0.0168932241351157 0.263457896062815 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/653 59/18639 0.101694915254237 2.90274353051107 0.0168932241351157 0.263457896062815 GO:0070063 RNA polymerase binding 6/653 59/18639 0.101694915254237 2.90274353051107 0.0168932241351157 0.263457896062815 GO:0043022 ribosome binding 9/653 112/18639 0.0803571428571429 2.29368573616277 0.0169109826784516 0.263457896062815 GO:0055102 lipase inhibitor activity 3/653 16/18639 0.1875 5.35193338437979 0.0170491678770808 0.263457896062815 GO:0098531 ligand-modulated transcription factor activity 6/653 60/18639 0.1 2.85436447166922 0.0182323098365569 0.272322023265978 GO:0003954 NADH dehydrogenase activity 5/653 44/18639 0.113636363636364 3.2435959905332 0.0182878037602305 0.272322023265978 GO:0032977 membrane insertase activity 3/653 17/18639 0.176470588235294 5.03711377353392 0.0201737708083716 0.295041398072435 GO:0009055 electron transfer activity 9/653 116/18639 0.0775862068965517 2.21459312457095 0.0207822824234659 0.298608584295063 GO:0043021 ribonucleoprotein complex binding 12/653 177/18639 0.0677966101694915 1.93516235367405 0.0222225302106099 0.313797452456716 GO:0022853 active monoatomic ion transmembrane transporter activity 9/653 118/18639 0.076271186440678 2.1770576478833 0.0229404465785802 0.316743302025248 GO:0070064 proline-rich region binding 3/653 18/18639 0.166666666666667 4.7572741194487 0.0235913814695239 0.316743302025248 GO:0098641 cadherin binding involved in cell-cell adhesion 3/653 18/18639 0.166666666666667 4.7572741194487 0.0235913814695239 0.316743302025248 GO:0043130 ubiquitin binding 8/653 100/18639 0.08 2.28349157733538 0.024154520740528 0.319073427201491 GO:0019001 guanyl nucleotide binding 22/653 400/18639 0.055 1.56990045941807 0.0253944860368595 0.324970063502936 GO:0032561 guanyl ribonucleotide binding 22/653 400/18639 0.055 1.56990045941807 0.0253944860368595 0.324970063502936 GO:0001540 amyloid-beta binding 7/653 83/18639 0.0843373493975904 2.40729533755235 0.0262813519402042 0.328645172986277 GO:0004866 endopeptidase inhibitor activity 11/653 161/18639 0.0683229813664596 1.9501869061094 0.0264842263944985 0.328645172986277 GO:0061135 endopeptidase regulator activity 12/653 184/18639 0.0652173913043478 1.86154204674079 0.0289232140572209 0.353553915117372 GO:0008173 RNA methyltransferase activity 6/653 67/18639 0.0895522388059701 2.55614728806199 0.0296715619023022 0.354715021599383 GO:0008175 tRNA methyltransferase activity 4/653 34/18639 0.117647058823529 3.35807584902261 0.0301199194426821 0.354715021599383 GO:0000339 RNA cap binding 3/653 20/18639 0.15 4.28154670750383 0.0313043551038689 0.354715021599383 GO:0031418 L-ascorbic acid binding 3/653 20/18639 0.15 4.28154670750383 0.0313043551038689 0.354715021599383 GO:0032934 sterol binding 6/653 68/18639 0.0882352941176471 2.51855688676696 0.0316168456370634 0.354715021599383 GO:1990841 promoter-specific chromatin binding 6/653 68/18639 0.0882352941176471 2.51855688676696 0.0316168456370634 0.354715021599383 GO:0030414 peptidase inhibitor activity 11/653 169/18639 0.0650887573964497 1.85787036617523 0.0359228345548598 0.397578398654462 GO:0140296 general transcription initiation factor binding 5/653 53/18639 0.0943396226415094 2.69279667138606 0.037484949662013 0.409335650309182 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 19/653 349/18639 0.0544412607449857 1.55395200463367 0.0391565117529518 0.411283119480203 GO:0023023 MHC protein complex binding 4/653 37/18639 0.108108108108108 3.08579942883159 0.0395412147644158 0.411283119480203 GO:0043394 proteoglycan binding 4/653 37/18639 0.108108108108108 3.08579942883159 0.0395412147644158 0.411283119480203 GO:0015485 cholesterol binding 5/653 54/18639 0.0925925925925926 2.64293006636039 0.0401668036363128 0.411283119480203 GO:0008649 rRNA methyltransferase activity 3/653 22/18639 0.136363636363636 3.89231518863984 0.0401741752850015 0.411283119480203 GO:0043178 alcohol binding 7/653 92/18639 0.0760869565217391 2.17179905453093 0.042574452019744 0.4304750148663 GO:0005525 GTP binding 20/653 378/18639 0.0529100529100529 1.51024575220594 0.0448452109346357 0.4358460846567 GO:0000295 adenine nucleotide transmembrane transporter activity 3/653 23/18639 0.130434782608696 3.72308409348159 0.0450341436308891 0.4358460846567 GO:0005131 growth hormone receptor binding 2/653 10/18639 0.2 5.70872894333844 0.0457664997319612 0.4358460846567 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/653 10/18639 0.2 5.70872894333844 0.0457664997319612 0.4358460846567 GO:0016427 tRNA (cytidine) methyltransferase activity 2/653 10/18639 0.2 5.70872894333844 0.0457664997319612 0.4358460846567 GO:0001221 transcription coregulator binding 8/653 115/18639 0.0695652173913043 1.98564484985685 0.0491228456976275 0.441241910071836 GO:0004867 serine-type endopeptidase inhibitor activity 7/653 95/18639 0.0736842105263158 2.10321592649311 0.0491928193209877 0.441241910071836 GO:0061791 GTPase motor activity 4/653 40/18639 0.1 2.85436447166922 0.0504562768766623 0.441241910071836 GO:1990606 membrane scission GTPase motor activity 4/653 40/18639 0.1 2.85436447166922 0.0504562768766623 0.441241910071836 GO:0016853 isomerase activity 11/653 180/18639 0.0611111111111111 1.74433384379786 0.052437741769547 0.441241910071836 GO:0001727 lipid kinase activity 4/653 41/18639 0.0975609756097561 2.78474582601875 0.0544253832284373 0.441241910071836 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/653 11/18639 0.181818181818182 5.18975358485313 0.0546653877717941 0.441241910071836 GO:0008199 ferric iron binding 2/653 11/18639 0.181818181818182 5.18975358485313 0.0546653877717941 0.441241910071836 GO:0015217 ADP transmembrane transporter activity 2/653 11/18639 0.181818181818182 5.18975358485313 0.0546653877717941 0.441241910071836 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/653 11/18639 0.181818181818182 5.18975358485313 0.0546653877717941 0.441241910071836 GO:0050998 nitric-oxide synthase binding 2/653 11/18639 0.181818181818182 5.18975358485313 0.0546653877717941 0.441241910071836 GO:0001786 phosphatidylserine binding 5/653 59/18639 0.0847457627118644 2.41895294209256 0.0552886135375514 0.441241910071836 GO:0004709 MAP kinase kinase kinase activity 3/653 25/18639 0.12 3.42523736600306 0.0555794005979475 0.441241910071836 GO:0120020 cholesterol transfer activity 3/653 25/18639 0.12 3.42523736600306 0.0555794005979475 0.441241910071836 GO:0046332 SMAD binding 6/653 79/18639 0.0759493670886076 2.16787175063485 0.0585486052782159 0.441241910071836 GO:0016859 cis-trans isomerase activity 4/653 42/18639 0.0952380952380952 2.71844235397068 0.0585583985020497 0.441241910071836 GO:0042056 chemoattractant activity 4/653 42/18639 0.0952380952380952 2.71844235397068 0.0585583985020497 0.441241910071836 GO:0043175 RNA polymerase core enzyme binding 4/653 42/18639 0.0952380952380952 2.71844235397068 0.0585583985020497 0.441241910071836 GO:0032182 ubiquitin-like protein binding 8/653 120/18639 0.0666666666666667 1.90290964777948 0.0601926976380293 0.441241910071836 GO:0015216 purine nucleotide transmembrane transporter activity 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0034237 protein kinase A regulatory subunit binding 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0050681 nuclear androgen receptor binding 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0051139 metal cation:proton antiporter activity 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0052742 phosphatidylinositol kinase activity 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0070412 R-SMAD binding 3/653 26/18639 0.115384615384615 3.29349746731064 0.0612526941832889 0.441241910071836 GO:0048306 calcium-dependent protein binding 6/653 80/18639 0.075 2.14077335375191 0.061514512884392 0.441241910071836 GO:0008200 ion channel inhibitor activity 4/653 43/18639 0.0930232558139535 2.65522276434346 0.0628540086866168 0.441241910071836 GO:0000340 RNA 7-methylguanosine cap binding 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0004300 enoyl-CoA hydratase activity 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0031543 peptidyl-proline dioxygenase activity 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0035197 siRNA binding 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0035497 cAMP response element binding 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0097371 MDM2/MDM4 family protein binding 2/653 12/18639 0.166666666666667 4.7572741194487 0.0641120724036001 0.441241910071836 GO:0061659 ubiquitin-like protein ligase activity 19/653 372/18639 0.0510752688172043 1.45787432692783 0.0656243972815126 0.447886511446324 GO:0016248 channel inhibitor activity 4/653 44/18639 0.0909090909090909 2.59487679242656 0.0673106291792555 0.448783115454621 GO:0030547 signaling receptor inhibitor activity 4/653 44/18639 0.0909090909090909 2.59487679242656 0.0673106291792555 0.448783115454621 GO:0015399 primary active transmembrane transporter activity 10/653 166/18639 0.0602409638554217 1.71949666968025 0.0673996620279834 0.448783115454621 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/653 167/18639 0.0598802395209581 1.70920028243666 0.0695671806710775 0.457235899678967 GO:0016755 aminoacyltransferase activity 24/653 496/18639 0.0483870967741935 1.38114409919478 0.0698373132335924 0.457235899678967 GO:0008009 chemokine activity 4/653 45/18639 0.0888888888888889 2.53721286370597 0.0719264182385741 0.457235899678967 GO:0141110 transporter inhibitor activity 4/653 45/18639 0.0888888888888889 2.53721286370597 0.0719264182385741 0.457235899678967 GO:0004842 ubiquitin-protein transferase activity 22/653 449/18639 0.0489977728285078 1.39857501952612 0.0721006504112416 0.457235899678967 GO:0061630 ubiquitin protein ligase activity 18/653 353/18639 0.0509915014164306 1.4554833000013 0.0725456079267348 0.457235899678967 GO:0051011 microtubule minus-end binding 2/653 13/18639 0.153846153846154 4.39132995641418 0.0740573777779889 0.457235899678967 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/653 13/18639 0.153846153846154 4.39132995641418 0.0740573777779889 0.457235899678967 GO:0140852 histone ubiquitin ligase activity 2/653 13/18639 0.153846153846154 4.39132995641418 0.0740573777779889 0.457235899678967 GO:0004860 protein kinase inhibitor activity 6/653 84/18639 0.0714285714285714 2.03883176547801 0.0742519837085502 0.457235899678967 GO:0000149 SNARE binding 7/653 106/18639 0.0660377358490566 1.88495766997024 0.0788062776683305 0.480509843561161 GO:0019787 ubiquitin-like protein transferase activity 23/653 479/18639 0.0480167014613779 1.37057166698104 0.0796462901713031 0.480509843561161 GO:0043236 laminin binding 3/653 29/18639 0.103448275862069 2.95279083276126 0.0797916223740146 0.480509843561161 GO:0004065 arylsulfatase activity 2/653 14/18639 0.142857142857143 4.07766353095603 0.084454892154668 0.490557139536688 GO:0005347 ATP transmembrane transporter activity 2/653 14/18639 0.142857142857143 4.07766353095603 0.084454892154668 0.490557139536688 GO:0016530 metallochaperone activity 2/653 14/18639 0.142857142857143 4.07766353095603 0.084454892154668 0.490557139536688 GO:0044548 S100 protein binding 2/653 14/18639 0.142857142857143 4.07766353095603 0.084454892154668 0.490557139536688 GO:0071933 Arp2/3 complex binding 2/653 14/18639 0.142857142857143 4.07766353095603 0.084454892154668 0.490557139536688 GO:0015215 nucleotide transmembrane transporter activity 3/653 30/18639 0.1 2.85436447166922 0.0864517866418969 0.498619811688124 GO:0016651 oxidoreductase activity, acting on NAD(P)H 6/653 88/18639 0.0681818181818182 1.94615759431992 0.0883784708295291 0.50616760566003 GO:0001222 transcription corepressor binding 4/653 49/18639 0.0816326530612245 2.33009344626059 0.0919361833422988 0.516679628609363 GO:0060590 ATPase regulator activity 4/653 49/18639 0.0816326530612245 2.33009344626059 0.0919361833422988 0.516679628609363 GO:0008327 methyl-CpG binding 3/653 31/18639 0.0967741935483871 2.76228819838957 0.0933384250246437 0.516679628609363 GO:0033218 amide binding 13/653 247/18639 0.0526315789473684 1.50229709035222 0.095212568537287 0.516679628609363 GO:0004129 cytochrome-c oxidase activity 2/653 15/18639 0.133333333333333 3.80581929555896 0.095260835067172 0.516679628609363 GO:0005523 tropomyosin binding 2/653 15/18639 0.133333333333333 3.80581929555896 0.095260835067172 0.516679628609363 GO:0030553 cGMP binding 2/653 15/18639 0.133333333333333 3.80581929555896 0.095260835067172 0.516679628609363 GO:0050700 CARD domain binding 2/653 15/18639 0.133333333333333 3.80581929555896 0.095260835067172 0.516679628609363 GO:0019210 kinase inhibitor activity 6/653 90/18639 0.0666666666666667 1.90290964777948 0.0959546007831453 0.517018539746027 GO:0097110 scaffold protein binding 5/653 70/18639 0.0714285714285714 2.03883176547801 0.0985600956181006 0.523966231419943 GO:0072341 modified amino acid binding 6/653 91/18639 0.0659340659340659 1.88199855274894 0.0998687855713293 0.523966231419943 GO:0051059 NF-kappaB binding 3/653 32/18639 0.09375 2.67596669218989 0.100442855107364 0.523966231419943 GO:0070717 poly-purine tract binding 3/653 32/18639 0.09375 2.67596669218989 0.100442855107364 0.523966231419943 GO:0120015 sterol transfer activity 3/653 32/18639 0.09375 2.67596669218989 0.100442855107364 0.523966231419943 GO:0008168 methyltransferase activity 11/653 204/18639 0.053921568627451 1.5391180974687 0.10424416327506 0.525762408651585 GO:0000062 fatty-acyl-CoA binding 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0004708 MAP kinase kinase activity 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0005159 insulin-like growth factor receptor binding 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0005521 lamin binding 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0008142 oxysterol binding 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/653 16/18639 0.125 3.56795558958652 0.106433930380042 0.525762408651585 GO:0008017 microtubule binding 14/653 276/18639 0.0507246376811594 1.44786603635395 0.107111639894124 0.525762408651585 GO:0140311 protein sequestering activity 3/653 33/18639 0.0909090909090909 2.59487679242656 0.107756188856048 0.525762408651585 GO:0042379 chemokine receptor binding 5/653 72/18639 0.0694444444444444 1.98219754977029 0.107848699210582 0.525762408651585 GO:0016860 intramolecular oxidoreductase activity 4/653 53/18639 0.0754716981132075 2.15423733710884 0.114287627576243 0.530708782453193 GO:0051018 protein kinase A binding 4/653 53/18639 0.0754716981132075 2.15423733710884 0.114287627576243 0.530708782453193 GO:0016831 carboxy-lyase activity 3/653 34/18639 0.0882352941176471 2.51855688676696 0.115269376218632 0.530708782453193 GO:0019825 oxygen binding 3/653 34/18639 0.0882352941176471 2.51855688676696 0.115269376218632 0.530708782453193 GO:0051427 hormone receptor binding 3/653 34/18639 0.0882352941176471 2.51855688676696 0.115269376218632 0.530708782453193 GO:0008083 growth factor activity 9/653 162/18639 0.0555555555555556 1.58575803981623 0.116377686748108 0.530708782453193 GO:0003713 transcription coactivator activity 13/653 256/18639 0.05078125 1.44948195826953 0.116540232407504 0.530708782453193 GO:0048029 monosaccharide binding 5/653 74/18639 0.0675675675675676 1.92862464301974 0.11754805487116 0.530708782453193 GO:0008484 sulfuric ester hydrolase activity 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:0036041 long-chain fatty acid binding 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:0045236 CXCR chemokine receptor binding 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:0048038 quinone binding 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:0070403 NAD+ binding 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:1901567 fatty acid derivative binding 2/653 17/18639 0.117647058823529 3.35807584902261 0.117935284989598 0.530708782453193 GO:0051287 NAD binding 4/653 54/18639 0.0740740740740741 2.11434405308831 0.120217293491437 0.53802165775676 GO:0019003 GDP binding 5/653 75/18639 0.0666666666666667 1.90290964777948 0.122547431317134 0.54546927309094 GO:0020037 heme binding 8/653 142/18639 0.0563380281690141 1.60809266009533 0.126186242947988 0.556024010180244 GO:0098632 cell-cell adhesion mediator activity 4/653 55/18639 0.0727272727272727 2.07590143394125 0.12627651513251 0.556024010180244 GO:0016854 racemase and epimerase activity 2/653 18/18639 0.111111111111111 3.17151607963247 0.129728272929608 0.561115935262362 GO:0000993 RNA polymerase II complex binding 3/653 36/18639 0.0833333333333333 2.37863705972435 0.13085853923701 0.561115935262362 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/653 36/18639 0.0833333333333333 2.37863705972435 0.13085853923701 0.561115935262362 GO:0005484 SNAP receptor activity 3/653 36/18639 0.0833333333333333 2.37863705972435 0.13085853923701 0.561115935262362 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/653 36/18639 0.0833333333333333 2.37863705972435 0.13085853923701 0.561115935262362 GO:0051082 unfolded protein binding 7/653 121/18639 0.0578512396694215 1.65128523154418 0.132687679484312 0.565995882800269 GO:0019207 kinase regulator activity 14/653 287/18639 0.0487804878048781 1.39237291300938 0.133941754080582 0.568384956435214 GO:0016741 transferase activity, transferring one-carbon groups 11/653 215/18639 0.0511627906976744 1.4603725203889 0.135454188121624 0.571840103461908 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/653 19/18639 0.105263157894737 3.00459418070444 0.141778424652916 0.586447120155244 GO:0043395 heparan sulfate proteoglycan binding 2/653 19/18639 0.105263157894737 3.00459418070444 0.141778424652916 0.586447120155244 GO:0097001 ceramide binding 2/653 19/18639 0.105263157894737 3.00459418070444 0.141778424652916 0.586447120155244 GO:0120227 acyl-CoA binding 2/653 19/18639 0.105263157894737 3.00459418070444 0.141778424652916 0.586447120155244 GO:0019209 kinase activator activity 8/653 148/18639 0.0540540540540541 1.54289971441579 0.148918651301868 0.612886308624269 GO:0003712 transcription coregulator activity 22/653 495/18639 0.0444444444444444 1.26860643185299 0.15146455140219 0.620247337991967 GO:0043024 ribosomal small subunit binding 2/653 20/18639 0.1 2.85436447166922 0.154053321269477 0.627709801590556 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/653 39/18639 0.0769230769230769 2.19566497820709 0.155509820505761 0.630507638585241 GO:0001098 basal transcription machinery binding 4/653 60/18639 0.0666666666666667 1.90290964777948 0.158379705730988 0.635847936243525 GO:0001099 basal RNA polymerase II transcription machinery binding 4/653 60/18639 0.0666666666666667 1.90290964777948 0.158379705730988 0.635847936243525 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/653 40/18639 0.075 2.14077335375191 0.164027675394607 0.640290714559801 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/653 40/18639 0.075 2.14077335375191 0.164027675394607 0.640290714559801 GO:0046906 tetrapyrrole binding 8/653 152/18639 0.0526315789473684 1.50229709035222 0.165103112275053 0.640290714559801 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/653 61/18639 0.0655737704918033 1.87171440765195 0.165133308914343 0.640290714559801 GO:0019905 syntaxin binding 4/653 61/18639 0.0655737704918033 1.87171440765195 0.165133308914343 0.640290714559801 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/653 21/18639 0.0952380952380952 2.71844235397068 0.166522493530205 0.640290714559801 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/653 21/18639 0.0952380952380952 2.71844235397068 0.166522493530205 0.640290714559801 GO:0051010 microtubule plus-end binding 2/653 21/18639 0.0952380952380952 2.71844235397068 0.166522493530205 0.640290714559801 GO:1904047 S-adenosyl-L-methionine binding 2/653 21/18639 0.0952380952380952 2.71844235397068 0.166522493530205 0.640290714559801 GO:0001530 lipopolysaccharide binding 3/653 41/18639 0.0731707317073171 2.08855936951406 0.172680487934042 0.654746850083243 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/653 41/18639 0.0731707317073171 2.08855936951406 0.172680487934042 0.654746850083243 GO:0140828 metal cation:monoatomic cation antiporter activity 3/653 41/18639 0.0731707317073171 2.08855936951406 0.172680487934042 0.654746850083243 GO:0005506 iron ion binding 8/653 154/18639 0.051948051948052 1.48278673852946 0.173487570955255 0.654775671024671 GO:0005496 steroid binding 6/653 108/18639 0.0555555555555556 1.58575803981623 0.178273372850096 0.669751799835911 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/653 22/18639 0.0909090909090909 2.59487679242656 0.179157325354725 0.669999312627944 GO:0004520 DNA endonuclease activity 3/653 42/18639 0.0714285714285714 2.03883176547801 0.181459110198041 0.675522778419072 GO:0019887 protein kinase regulator activity 12/653 255/18639 0.0470588235294118 1.34323033960904 0.185658821319063 0.686130350178163 GO:0004536 DNA nuclease activity 4/653 64/18639 0.0625 1.78397779479326 0.185984050964044 0.686130350178163 GO:0003924 GTPase activity 15/653 331/18639 0.0453172205438066 1.2935186427504 0.187262795950015 0.686425579213881 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/653 43/18639 0.0697674418604651 1.99141707325759 0.190354492811398 0.686425579213881 GO:0003887 DNA-directed DNA polymerase activity 2/653 23/18639 0.0869565217391304 2.48205606232106 0.191930961709376 0.686425579213881 GO:0004602 glutathione peroxidase activity 2/653 23/18639 0.0869565217391304 2.48205606232106 0.191930961709376 0.686425579213881 GO:0008171 O-methyltransferase activity 2/653 23/18639 0.0869565217391304 2.48205606232106 0.191930961709376 0.686425579213881 GO:0042171 lysophosphatidic acid acyltransferase activity 2/653 23/18639 0.0869565217391304 2.48205606232106 0.191930961709376 0.686425579213881 GO:0071617 lysophospholipid acyltransferase activity 2/653 23/18639 0.0869565217391304 2.48205606232106 0.191930961709376 0.686425579213881 GO:0001223 transcription coactivator binding 3/653 44/18639 0.0681818181818182 1.94615759431992 0.199357702345457 0.709886774873607 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/653 24/18639 0.0833333333333333 2.37863705972435 0.204818220649779 0.719158945841193 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/653 24/18639 0.0833333333333333 2.37863705972435 0.204818220649779 0.719158945841193 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/653 24/18639 0.0833333333333333 2.37863705972435 0.204818220649779 0.719158945841193 GO:0016922 nuclear receptor binding 7/653 137/18639 0.0510948905109489 1.45843440158281 0.205473984526055 0.719158945841193 GO:0042605 peptide antigen binding 3/653 45/18639 0.0666666666666667 1.90290964777948 0.20845993692452 0.726505056770988 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/653 46/18639 0.0652173913043478 1.86154204674079 0.217652540162251 0.752635114589028 GO:0042974 nuclear retinoic acid receptor binding 2/653 25/18639 0.08 2.28349157733538 0.217795509349938 0.752635114589028 GO:0002039 p53 binding 4/653 69/18639 0.0579710144927536 1.65470404154737 0.222441049184396 0.765458904546303 GO:0005504 fatty acid binding 3/653 47/18639 0.0638297872340425 1.82193476915057 0.226927013540737 0.772908738481726 GO:0051219 phosphoprotein binding 5/653 93/18639 0.0537634408602151 1.53460455466087 0.227033188762916 0.772908738481726 GO:0019208 phosphatase regulator activity 6/653 117/18639 0.0512820512820513 1.46377665213806 0.227437125731497 0.772908738481726 GO:0004435 phosphatidylinositol phospholipase C activity 2/653 26/18639 0.0769230769230769 2.19566497820709 0.230840743947159 0.774830202019359 GO:0008143 poly(A) binding 2/653 26/18639 0.0769230769230769 2.19566497820709 0.230840743947159 0.774830202019359 GO:0043548 phosphatidylinositol 3-kinase binding 2/653 26/18639 0.0769230769230769 2.19566497820709 0.230840743947159 0.774830202019359 GO:0016410 N-acyltransferase activity 5/653 94/18639 0.0531914893617021 1.51827897429214 0.233489741304133 0.780522849502387 GO:0008276 protein methyltransferase activity 5/653 95/18639 0.0526315789473684 1.50229709035222 0.239997619772744 0.79901646582877 GO:0005104 fibroblast growth factor receptor binding 2/653 27/18639 0.0740740740740741 2.11434405308831 0.243933273039122 0.80233474144193 GO:0005385 zinc ion transmembrane transporter activity 2/653 27/18639 0.0740740740740741 2.11434405308831 0.243933273039122 0.80233474144193 GO:0035255 ionotropic glutamate receptor binding 2/653 27/18639 0.0740740740740741 2.11434405308831 0.243933273039122 0.80233474144193 GO:0015605 organophosphate ester transmembrane transporter activity 3/653 50/18639 0.06 1.71261868300153 0.255159257495781 0.80301154925365 GO:0019789 SUMO transferase activity 2/653 28/18639 0.0714285714285714 2.03883176547801 0.257053804676195 0.80301154925365 GO:0046625 sphingolipid binding 2/653 28/18639 0.0714285714285714 2.03883176547801 0.257053804676195 0.80301154925365 GO:0051019 mitogen-activated protein kinase binding 2/653 28/18639 0.0714285714285714 2.03883176547801 0.257053804676195 0.80301154925365 GO:0140104 molecular carrier activity 11/653 249/18639 0.0441767068273092 1.26096422443219 0.2581071658916 0.80301154925365 GO:0003684 damaged DNA binding 4/653 74/18639 0.0540540540540541 1.54289971441579 0.260557952744067 0.80301154925365 GO:0016830 carbon-carbon lyase activity 3/653 51/18639 0.0588235294117647 1.67903792451131 0.264679738398385 0.80301154925365 GO:0030544 Hsp70 protein binding 3/653 51/18639 0.0588235294117647 1.67903792451131 0.264679738398385 0.80301154925365 GO:0044183 protein folding chaperone 4/653 75/18639 0.0533333333333333 1.52232771822358 0.268333193387838 0.80301154925365 GO:0004629 phospholipase C activity 2/653 29/18639 0.0689655172413793 1.96852722184084 0.270184336698577 0.80301154925365 GO:0005080 protein kinase C binding 3/653 52/18639 0.0576923076923077 1.64674873365532 0.27424230203169 0.80301154925365 GO:0017022 myosin binding 4/653 76/18639 0.0526315789473684 1.50229709035222 0.276149252928097 0.80301154925365 GO:0051536 iron-sulfur cluster binding 4/653 76/18639 0.0526315789473684 1.50229709035222 0.276149252928097 0.80301154925365 GO:0098631 cell adhesion mediator activity 4/653 76/18639 0.0526315789473684 1.50229709035222 0.276149252928097 0.80301154925365 GO:0015631 tubulin binding 16/653 385/18639 0.0415584415584416 1.18622939082357 0.276955174776542 0.80301154925365 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 10/653 229/18639 0.0436681222707424 1.24644736754114 0.283215209227736 0.80301154925365 GO:0031624 ubiquitin conjugating enzyme binding 2/653 30/18639 0.0666666666666667 1.90290964777948 0.283308090274056 0.80301154925365 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/653 30/18639 0.0666666666666667 1.90290964777948 0.283308090274056 0.80301154925365 GO:0048019 receptor antagonist activity 2/653 30/18639 0.0666666666666667 1.90290964777948 0.283308090274056 0.80301154925365 GO:0004864 protein phosphatase inhibitor activity 3/653 53/18639 0.0566037735849057 1.61567800283163 0.283839582499016 0.80301154925365 GO:0005544 calcium-dependent phospholipid binding 3/653 53/18639 0.0566037735849057 1.61567800283163 0.283839582499016 0.80301154925365 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/653 53/18639 0.0566037735849057 1.61567800283163 0.283839582499016 0.80301154925365 GO:0051540 metal cluster binding 4/653 77/18639 0.051948051948052 1.48278673852946 0.284002025076788 0.80301154925365 GO:0003925 G protein activity 3/653 54/18639 0.0555555555555556 1.58575803981623 0.293464423028874 0.80301154925365 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/653 54/18639 0.0555555555555556 1.58575803981623 0.293464423028874 0.80301154925365 GO:0017069 snRNA binding 3/653 54/18639 0.0555555555555556 1.58575803981623 0.293464423028874 0.80301154925365 GO:0050661 NADP binding 3/653 54/18639 0.0555555555555556 1.58575803981623 0.293464423028874 0.80301154925365 GO:0140463 chromatin-protein adaptor activity 3/653 54/18639 0.0555555555555556 1.58575803981623 0.293464423028874 0.80301154925365 GO:0016411 acylglycerol O-acyltransferase activity 2/653 31/18639 0.0645161290322581 1.84152546559304 0.296409446498153 0.80301154925365 GO:0017147 Wnt-protein binding 2/653 31/18639 0.0645161290322581 1.84152546559304 0.296409446498153 0.80301154925365 GO:0033293 monocarboxylic acid binding 4/653 79/18639 0.0506329113924051 1.44524783375657 0.299801559686127 0.80301154925365 GO:0000182 rDNA binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0001094 TFIID-class transcription factor complex binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0005381 iron ion transmembrane transporter activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0008140 cAMP response element binding protein binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0015279 store-operated calcium channel activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0015643 toxic substance binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0016868 intramolecular phosphotransferase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0031720 haptoglobin binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0032356 oxidized DNA binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0032395 MHC class II receptor activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0035374 chondroitin sulfate binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0043208 glycosphingolipid binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0043295 glutathione binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0043422 protein kinase B binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0050815 phosphoserine residue binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0051880 G-quadruplex DNA binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0070513 death domain binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0097177 mitochondrial ribosome binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0099122 RNA polymerase II C-terminal domain binding 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0140940 histone H2A methyltransferase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0140999 histone H3K4 trimethyltransferase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:1990259 histone H2AQ104 methyltransferase activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:1990757 ubiquitin ligase activator activity 1/653 10/18639 0.1 2.85436447166922 0.300026293127737 0.80301154925365 GO:0015106 bicarbonate transmembrane transporter activity 2/653 32/18639 0.0625 1.78397779479326 0.309473885924205 0.820256027740855 GO:0030515 snoRNA binding 2/653 32/18639 0.0625 1.78397779479326 0.309473885924205 0.820256027740855 GO:0043425 bHLH transcription factor binding 2/653 32/18639 0.0625 1.78397779479326 0.309473885924205 0.820256027740855 GO:0019212 phosphatase inhibitor activity 3/653 56/18639 0.0535714285714286 1.52912382410851 0.31276922169517 0.822961585821264 GO:0008013 beta-catenin binding 5/653 106/18639 0.0471698113207547 1.34639833569303 0.31421117886798 0.822961585821264 GO:0019888 protein phosphatase regulator activity 5/653 107/18639 0.0467289719626168 1.33381517367721 0.321128529309962 0.822961585821264 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/653 57/18639 0.0526315789473684 1.50229709035222 0.32243593751887 0.822961585821264 GO:0071889 14-3-3 protein binding 2/653 33/18639 0.0606060606060606 1.72991786161771 0.322487930896344 0.822961585821264 GO:0003953 NAD+ nucleosidase activity 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0008526 phosphatidylinositol transfer activity 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0019107 myristoyltransferase activity 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0019215 intermediate filament binding 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0050786 RAGE receptor binding 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0140031 phosphorylation-dependent protein binding 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0180030 inositol phosphate kinase activity 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:1900750 oligopeptide binding 1/653 11/18639 0.0909090909090909 2.59487679242656 0.324562383663331 0.822961585821264 GO:0099106 ion channel regulator activity 7/653 160/18639 0.04375 1.24878445635528 0.329163241202404 0.825930146624547 GO:0030165 PDZ domain binding 4/653 83/18639 0.0481927710843374 1.3755973357442 0.331667023283948 0.825930146624547 GO:0061980 regulatory RNA binding 3/653 58/18639 0.0517241379310345 1.47639541638063 0.332103731615388 0.825930146624547 GO:0008376 acetylgalactosaminyltransferase activity 2/653 34/18639 0.0588235294117647 1.67903792451131 0.335439090563702 0.825930146624547 GO:0015035 protein-disulfide reductase activity 2/653 34/18639 0.0588235294117647 1.67903792451131 0.335439090563702 0.825930146624547 GO:0015459 potassium channel regulator activity 3/653 59/18639 0.0508474576271186 1.45137176525554 0.341766527063879 0.825930146624547 GO:0036002 pre-mRNA binding 3/653 59/18639 0.0508474576271186 1.45137176525554 0.341766527063879 0.825930146624547 GO:0045309 protein phosphorylated amino acid binding 3/653 59/18639 0.0508474576271186 1.45137176525554 0.341766527063879 0.825930146624547 GO:0005078 MAP-kinase scaffold activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0005095 GTPase inhibitor activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0015368 calcium:monoatomic cation antiporter activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0016273 arginine N-methyltransferase activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0016274 protein-arginine N-methyltransferase activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0016423 tRNA (guanine) methyltransferase activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0036009 protein-glutamine N-methyltransferase activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0043047 single-stranded telomeric DNA binding 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0045295 gamma-catenin binding 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0070679 inositol 1,4,5 trisphosphate binding 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/653 12/18639 0.0833333333333333 2.37863705972435 0.348239684686943 0.825930146624547 GO:0034061 DNA polymerase activity 2/653 35/18639 0.0571428571428571 1.63106541238241 0.348315808459189 0.825930146624547 GO:0043015 gamma-tubulin binding 2/653 35/18639 0.0571428571428571 1.63106541238241 0.348315808459189 0.825930146624547 GO:0061631 ubiquitin conjugating enzyme activity 2/653 35/18639 0.0571428571428571 1.63106541238241 0.348315808459189 0.825930146624547 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/653 86/18639 0.0465116279069767 1.32761138217173 0.355681344930775 0.825930146624547 GO:0030295 protein kinase activator activity 6/653 139/18639 0.0431654676258993 1.23209977194355 0.360654406469348 0.825930146624547 GO:0140101 catalytic activity, acting on a tRNA 6/653 139/18639 0.0431654676258993 1.23209977194355 0.360654406469348 0.825930146624547 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/653 36/18639 0.0555555555555556 1.58575803981623 0.361107412531082 0.825930146624547 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/653 36/18639 0.0555555555555556 1.58575803981623 0.361107412531082 0.825930146624547 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/653 36/18639 0.0555555555555556 1.58575803981623 0.361107412531082 0.825930146624547 GO:0016874 ligase activity 7/653 167/18639 0.0419161676646707 1.19644019770566 0.369144732920432 0.825930146624547 GO:0002161 aminoacyl-tRNA editing activity 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0043560 insulin receptor substrate binding 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0045159 myosin II binding 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0046975 histone H3K36 methyltransferase activity 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0089720 caspase binding 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0097157 pre-mRNA intronic binding 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0140666 annealing activity 1/653 13/18639 0.0769230769230769 2.19566497820709 0.371088210262689 0.825930146624547 GO:0004197 cysteine-type endopeptidase activity 4/653 88/18639 0.0454545454545455 1.29743839621328 0.371692697913934 0.825930146624547 GO:0030551 cyclic nucleotide binding 2/653 37/18639 0.0540540540540541 1.54289971441579 0.373804067520293 0.825930146624547 GO:0016247 channel regulator activity 7/653 168/18639 0.0416666666666667 1.18931852986217 0.374889594068798 0.825930146624547 GO:0042277 peptide binding 10/653 249/18639 0.0401606425702811 1.14633111312017 0.375261977809787 0.825930146624547 GO:0017124 SH3 domain binding 5/653 115/18639 0.0434782608695652 1.24102803116053 0.376889179979547 0.825930146624547 GO:0003727 single-stranded RNA binding 4/653 89/18639 0.0449438202247191 1.28286043670527 0.379688895497735 0.825930146624547 GO:0141108 transporter regulator activity 7/653 170/18639 0.0411764705882353 1.17532654715791 0.386391283452204 0.825930146624547 GO:0042162 telomeric DNA binding 2/653 38/18639 0.0526315789473684 1.50229709035222 0.386396729580704 0.825930146624547 GO:0106310 protein serine kinase activity 14/653 361/18639 0.038781163434903 1.10695575078585 0.38710852430521 0.825930146624547 GO:0004705 JUN kinase activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0005161 platelet-derived growth factor receptor binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0005344 oxygen carrier activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0005545 1-phosphatidylinositol binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0008174 mRNA methyltransferase activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0008331 high voltage-gated calcium channel activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0015386 potassium:proton antiporter activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0030983 mismatched DNA binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0032454 histone H3K9 demethylase activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0042043 neurexin family protein binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0043176 amine binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0046030 inositol trisphosphate phosphatase activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0061665 SUMO ligase activity 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0070742 C2H2 zinc finger domain binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0098847 sequence-specific single stranded DNA binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:1990825 sequence-specific mRNA binding 1/653 14/18639 0.0714285714285714 2.03883176547801 0.39313692704023 0.825930146624547 GO:0038024 cargo receptor activity 3/653 65/18639 0.0461538461538462 1.31739898692426 0.399325382764035 0.825930146624547 GO:0120013 lipid transfer activity 3/653 65/18639 0.0461538461538462 1.31739898692426 0.399325382764035 0.825930146624547 GO:0031267 small GTPase binding 11/653 283/18639 0.03886925795053 1.10947028934139 0.405956880892421 0.825930146624547 GO:0015036 disulfide oxidoreductase activity 2/653 40/18639 0.05 1.42718223583461 0.411237599236299 0.825930146624547 GO:0051213 dioxygenase activity 4/653 93/18639 0.043010752688172 1.2276836437287 0.411537385110242 0.825930146624547 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0031386 protein tag activity 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0033130 acetylcholine receptor binding 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0051371 muscle alpha-actinin binding 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0061578 K63-linked deubiquitinase activity 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0120283 protein serine/threonine kinase binding 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0140776 protein-containing complex destabilizing activity 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0141047 molecular tag activity 1/653 15/18639 0.0666666666666667 1.90290964777948 0.414413790752591 0.825930146624547 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/653 67/18639 0.0447761194029851 1.27807364403099 0.418231184779163 0.825930146624547 GO:0042054 histone methyltransferase activity 3/653 67/18639 0.0447761194029851 1.27807364403099 0.418231184779163 0.825930146624547 GO:0003697 single-stranded DNA binding 5/653 121/18639 0.0413223140495868 1.17948945110298 0.418717821293676 0.825930146624547 GO:0004252 serine-type endopeptidase activity 7/653 176/18639 0.0397727272727273 1.13525859668662 0.420902462942054 0.825930146624547 GO:0004812 aminoacyl-tRNA ligase activity 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0042169 SH2 domain binding 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0140318 protein transporter activity 2/653 41/18639 0.0487804878048781 1.39237291300938 0.4234712972518 0.825930146624547 GO:0051020 GTPase binding 12/653 315/18639 0.0380952380952381 1.08737694158827 0.425060841056811 0.825930146624547 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 5/653 122/18639 0.040983606557377 1.16982150478247 0.425652334414153 0.825930146624547 GO:0030145 manganese ion binding 3/653 68/18639 0.0441176470588235 1.25927844338348 0.427611110074125 0.825930146624547 GO:0140223 general transcription initiation factor activity 3/653 68/18639 0.0441176470588235 1.25927844338348 0.427611110074125 0.825930146624547 GO:0004707 MAP kinase activity 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0015385 sodium:proton antiporter activity 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0016722 oxidoreductase activity, acting on metal ions 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0017070 U6 snRNA binding 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0030275 LRR domain binding 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0043023 ribosomal large subunit binding 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0097027 ubiquitin-protein transferase activator activity 1/653 16/18639 0.0625 1.78397779479326 0.434945781444095 0.825930146624547 GO:0022804 active transmembrane transporter activity 17/653 457/18639 0.037199124726477 1.06179859996448 0.435058906136428 0.825930146624547 GO:0008307 structural constituent of muscle 2/653 42/18639 0.0476190476190476 1.35922117698534 0.435571906604488 0.825930146624547 GO:0035198 miRNA binding 2/653 42/18639 0.0476190476190476 1.35922117698534 0.435571906604488 0.825930146624547 GO:0005125 cytokine activity 9/653 234/18639 0.0384615384615385 1.09783248910355 0.435690828672007 0.825930146624547 GO:0008080 N-acetyltransferase activity 3/653 69/18639 0.0434782608695652 1.24102803116053 0.436937021932749 0.825930146624547 GO:0016279 protein-lysine N-methyltransferase activity 3/653 69/18639 0.0434782608695652 1.24102803116053 0.436937021932749 0.825930146624547 GO:0016278 lysine N-methyltransferase activity 3/653 70/18639 0.0428571428571429 1.22329905928681 0.446205142955223 0.825930146624547 GO:0048156 tau protein binding 2/653 43/18639 0.0465116279069767 1.32761138217173 0.447533731667565 0.825930146624547 GO:0003774 cytoskeletal motor activity 6/653 153/18639 0.0392156862745098 1.11935861634087 0.448323705260646 0.825930146624547 GO:0004175 endopeptidase activity 15/653 405/18639 0.037037037037037 1.05717202654416 0.450092883516662 0.825930146624547 GO:0008170 N-methyltransferase activity 4/653 98/18639 0.0408163265306122 1.16504672313029 0.45082548155234 0.825930146624547 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0004659 prenyltransferase activity 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0005092 GDP-dissociation inhibitor activity 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0008429 phosphatidylethanolamine binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0016018 cyclosporin A binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0031489 myosin V binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0046965 nuclear retinoid X receptor binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0070402 NADPH binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0070492 oligosaccharide binding 1/653 17/18639 0.0588235294117647 1.67903792451131 0.454758937472501 0.825930146624547 GO:0008237 metallopeptidase activity 7/653 184/18639 0.0380434782608696 1.08589952726546 0.466579028765197 0.825930146624547 GO:0046915 transition metal ion transmembrane transporter activity 2/653 45/18639 0.0444444444444444 1.26860643185299 0.471021019263028 0.825930146624547 GO:0051539 4 iron, 4 sulfur cluster binding 2/653 45/18639 0.0444444444444444 1.26860643185299 0.471021019263028 0.825930146624547 GO:0035591 signaling adaptor activity 5/653 129/18639 0.0387596899224806 1.10634281847644 0.473648657608572 0.825930146624547 GO:0000900 mRNA regulatory element binding translation repressor activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0004706 JUN kinase kinase kinase activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0008409 5'-3' exonuclease activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0008525 phosphatidylcholine transporter activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0017075 syntaxin-1 binding 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0035615 clathrin adaptor activity 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0070628 proteasome binding 1/653 18/18639 0.0555555555555556 1.58575803981623 0.473878388327965 0.825930146624547 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/653 243/18639 0.037037037037037 1.05717202654416 0.480413465623213 0.825930146624547 GO:0004180 carboxypeptidase activity 2/653 46/18639 0.0434782608695652 1.24102803116053 0.482537768313063 0.825930146624547 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/653 46/18639 0.0434782608695652 1.24102803116053 0.482537768313063 0.825930146624547 GO:0031491 nucleosome binding 3/653 74/18639 0.0405405405405405 1.15717478581185 0.482630787438844 0.825930146624547 GO:0031406 carboxylic acid binding 7/653 187/18639 0.0374331550802139 1.06847867923447 0.483505153792002 0.825930146624547 GO:0003779 actin binding 16/653 443/18639 0.036117381489842 1.03092170534328 0.486571231512277 0.825930146624547 GO:0140597 protein carrier chaperone 7/653 188/18639 0.0372340425531915 1.0627952820045 0.489114493377121 0.825930146624547 GO:0140098 catalytic activity, acting on RNA 14/653 387/18639 0.0361757105943152 1.03258663057801 0.489769620243816 0.825930146624547 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0004711 ribosomal protein S6 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0035175 histone H3S10 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0035979 histone H2AXS139 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0044022 histone H3S28 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0044023 histone H4S1 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0044024 histone H2AS1 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0044025 histone H2BS14 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0072354 histone H3T3 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0072371 histone H2AS121 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0140823 histone H2BS36 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0140855 histone H3S57 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0140995 histone H2A kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0140997 histone H4 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0140998 histone H2B kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:1990244 histone H2AT120 kinase activity 9/653 245/18639 0.036734693877551 1.04854205081726 0.490252716831573 0.825930146624547 GO:0003725 double-stranded RNA binding 3/653 75/18639 0.04 1.14174578866769 0.491559853857636 0.825930146624547 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:0022821 solute:potassium antiporter activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:0042800 histone H3K4 methyltransferase activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:0070003 threonine-type peptidase activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:1990380 K48-linked deubiquitinase activity 1/653 19/18639 0.0526315789473684 1.50229709035222 0.492328386309912 0.825930146624547 GO:0001784 phosphotyrosine residue binding 2/653 47/18639 0.0425531914893617 1.21462317943371 0.493898246302944 0.825930146624547 GO:0140938 histone H3 methyltransferase activity 2/653 47/18639 0.0425531914893617 1.21462317943371 0.493898246302944 0.825930146624547 GO:0043177 organic acid binding 7/653 189/18639 0.037037037037037 1.05717202654416 0.494705889527318 0.825930146624547 GO:0004677 DNA-dependent protein kinase activity 9/653 246/18639 0.0365853658536585 1.04427968475703 0.495154703287732 0.825930146624547 GO:0140857 histone H3T45 kinase activity 9/653 246/18639 0.0365853658536585 1.04427968475703 0.495154703287732 0.825930146624547 GO:0035402 histone H3T11 kinase activity 9/653 247/18639 0.0364372469635627 1.04005183178231 0.500044058338349 0.828965047789961 GO:0035403 histone H3T6 kinase activity 9/653 247/18639 0.0364372469635627 1.04005183178231 0.500044058338349 0.828965047789961 GO:0004679 AMP-activated protein kinase activity 9/653 248/18639 0.0362903225806452 1.03585807439609 0.504920141340435 0.828965047789961 GO:0032266 phosphatidylinositol-3-phosphate binding 2/653 48/18639 0.0416666666666667 1.18931852986217 0.505099255823137 0.828965047789961 GO:0140693 molecular condensate scaffold activity 2/653 48/18639 0.0416666666666667 1.18931852986217 0.505099255823137 0.828965047789961 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0016004 phospholipase activator activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0016408 C-acyltransferase activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0016505 peptidase activator activity involved in apoptotic process 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0030742 GTP-dependent protein binding 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0052745 inositol phosphate phosphatase activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0061608 nuclear import signal receptor activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0140939 histone H4 methyltransferase activity 1/653 20/18639 0.05 1.42718223583461 0.510132337101514 0.828965047789961 GO:0015297 antiporter activity 5/653 135/18639 0.037037037037037 1.05717202654416 0.51372270556318 0.830517706116125 GO:0035254 glutamate receptor binding 2/653 49/18639 0.0408163265306122 1.16504672313029 0.516138014359959 0.830517706116125 GO:0016779 nucleotidyltransferase activity 5/653 136/18639 0.0367647058823529 1.04939870281957 0.520281466532078 0.830517706116125 GO:0030246 carbohydrate binding 10/653 280/18639 0.0357142857142857 1.01941588273901 0.520627171733896 0.830517706116125 GO:0008236 serine-type peptidase activity 7/653 194/18639 0.0360824742268041 1.0299253248291 0.522362030850033 0.830517706116125 GO:0016835 carbon-oxygen lyase activity 3/653 79/18639 0.0379746835443038 1.08393587531742 0.526485934102099 0.830517706116125 GO:0048020 CCR chemokine receptor binding 2/653 50/18639 0.04 1.14174578866769 0.527012129229299 0.830517706116125 GO:0008373 sialyltransferase activity 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0010314 phosphatidylinositol-5-phosphate binding 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0019200 carbohydrate kinase activity 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0035613 RNA stem-loop binding 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0036122 BMP binding 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0051428 peptide hormone receptor binding 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0072542 protein phosphatase activator activity 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0140312 cargo adaptor activity 1/653 21/18639 0.0476190476190476 1.35922117698534 0.527312829280079 0.830517706116125 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 17/653 484/18639 0.0351239669421488 1.00256603343754 0.530910812399921 0.834579568820605 GO:0140767 enzyme-substrate adaptor activity 5/653 139/18639 0.0359712230215827 1.02674980995296 0.539725444942749 0.837589106520893 GO:0004222 metalloendopeptidase activity 4/653 110/18639 0.0363636363636364 1.03795071697063 0.541029629684625 0.837589106520893 GO:0030971 receptor tyrosine kinase binding 3/653 81/18639 0.037037037037037 1.05717202654416 0.543443425109793 0.837589106520893 GO:0008093 cytoskeletal anchor activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0034062 5'-3' RNA polymerase activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0050321 tau-protein kinase activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0061133 endopeptidase activator activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0097747 RNA polymerase activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0140517 protein-RNA adaptor activity 1/653 22/18639 0.0454545454545455 1.29743839621328 0.543891662800335 0.837589106520893 GO:0017171 serine hydrolase activity 7/653 198/18639 0.0353535353535354 1.00911875261033 0.544074975175964 0.837589106520893 GO:1902936 phosphatidylinositol bisphosphate binding 4/653 111/18639 0.036036036036036 1.02859980961053 0.548210286659137 0.842371903890868 GO:0016829 lyase activity 7/653 200/18639 0.035 0.999027565084227 0.554776795624828 0.849166312670869 GO:0001216 DNA-binding transcription activator activity 17/653 491/18639 0.0346232179226069 0.988272831331502 0.555116899207366 0.849166312670869 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/653 53/18639 0.0377358490566038 1.07711866855442 0.558628040391387 0.849166312670869 GO:0005212 structural constituent of eye lens 1/653 23/18639 0.0434782608695652 1.24102803116053 0.559889876486287 0.849166312670869 GO:0017134 fibroblast growth factor binding 1/653 23/18639 0.0434782608695652 1.24102803116053 0.559889876486287 0.849166312670869 GO:0031681 G-protein beta-subunit binding 1/653 23/18639 0.0434782608695652 1.24102803116053 0.559889876486287 0.849166312670869 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/653 23/18639 0.0434782608695652 1.24102803116053 0.559889876486287 0.849166312670869 GO:0004527 exonuclease activity 3/653 84/18639 0.0357142857142857 1.01941588273901 0.568205663954009 0.849757100138417 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/653 54/18639 0.037037037037037 1.05717202654416 0.568826641059176 0.849757100138417 GO:0019955 cytokine binding 5/653 144/18639 0.0347222222222222 0.991098774885146 0.571289529008389 0.849757100138417 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0005540 hyaluronic acid binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0030215 semaphorin receptor binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0030552 cAMP binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0035035 histone acetyltransferase binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0050431 transforming growth factor beta binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0050699 WW domain binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0060229 lipase activator activity 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0070840 dynein complex binding 1/653 24/18639 0.0416666666666667 1.18931852986217 0.575327774566136 0.849757100138417 GO:0003714 transcription corepressor activity 7/653 204/18639 0.0343137254901961 0.979438789298261 0.575842723537022 0.849757100138417 GO:0008374 O-acyltransferase activity 2/653 55/18639 0.0363636363636364 1.03795071697063 0.578853688674478 0.852663976662586 GO:0141003 histone H2AX kinase activity 12/653 354/18639 0.0338983050847458 0.967581176837023 0.587759250519805 0.853737349284941 GO:0000030 mannosyltransferase activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0003707 nuclear steroid receptor activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0008483 transaminase activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0017025 TBP-class protein binding 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0019211 phosphatase activator activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0047617 fatty acyl-CoA hydrolase activity 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/653 25/18639 0.04 1.14174578866769 0.590224952283477 0.853737349284941 GO:0008081 phosphoric diester hydrolase activity 3/653 87/18639 0.0344827586206897 0.98426361092042 0.592124240170119 0.853737349284941 GO:0140996 histone H3 kinase activity 12/653 357/18639 0.0336134453781513 0.959450242577889 0.599520965772495 0.853737349284941 GO:0051015 actin filament binding 7/653 209/18639 0.0334928229665072 0.956007239315049 0.601489683463986 0.853737349284941 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0004529 DNA exonuclease activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0005112 Notch binding 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0008157 protein phosphatase 1 binding 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0016289 acyl-CoA hydrolase activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0019865 immunoglobulin binding 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0030507 spectrin binding 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0050750 low-density lipoprotein particle receptor binding 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0070006 metalloaminopeptidase activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0120014 phospholipid transfer activity 1/653 26/18639 0.0384615384615385 1.09783248910355 0.60460032061693 0.853737349284941 GO:0019842 vitamin binding 5/653 150/18639 0.0333333333333333 0.95145482388974 0.607626693347067 0.854179889686284 GO:0008408 3'-5' exonuclease activity 2/653 58/18639 0.0344827586206897 0.98426361092042 0.607901584500818 0.854179889686284 GO:0035173 histone kinase activity 12/653 360/18639 0.0333333333333333 0.95145482388974 0.611128668747419 0.854179889686284 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/653 181/18639 0.0331491712707182 0.946198167404161 0.612038548560474 0.854179889686284 GO:0031593 polyubiquitin modification-dependent protein binding 2/653 59/18639 0.0338983050847458 0.967581176837023 0.617239656691588 0.854179889686284 GO:0070888 E-box binding 2/653 59/18639 0.0338983050847458 0.967581176837023 0.617239656691588 0.854179889686284 GO:0004364 glutathione transferase activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0005044 scavenger receptor activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0008266 poly(U) RNA binding 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0008395 steroid hydroxylase activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0015252 proton channel activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/653 27/18639 0.037037037037037 1.05717202654416 0.618472130139153 0.854179889686284 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/653 122/18639 0.0327868852459016 0.935857203825973 0.62305333496098 0.855358177062826 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/653 60/18639 0.0333333333333333 0.95145482388974 0.626405904679961 0.855358177062826 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/653 60/18639 0.0333333333333333 0.95145482388974 0.626405904679961 0.855358177062826 GO:0005126 cytokine receptor binding 9/653 275/18639 0.0327272727272727 0.934155645273563 0.629524993452472 0.855358177062826 GO:0052689 carboxylic ester hydrolase activity 3/653 92/18639 0.0326086956521739 0.930771023370397 0.630036746700192 0.855358177062826 GO:0016866 intramolecular transferase activity 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0045499 chemorepellent activity 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0051393 alpha-actinin binding 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0051537 2 iron, 2 sulfur cluster binding 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0051959 dynein light intermediate chain binding 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:0141052 histone H3 demethylase activity 1/653 28/18639 0.0357142857142857 1.01941588273901 0.631857994045189 0.855358177062826 GO:1901981 phosphatidylinositol phosphate binding 6/653 185/18639 0.0324324324324324 0.925739828649476 0.633170443227597 0.855720450500663 GO:0016836 hydro-lyase activity 2/653 61/18639 0.0327868852459016 0.935857203825973 0.635400887749176 0.857320143437521 GO:0008234 cysteine-type peptidase activity 6/653 187/18639 0.0320855614973262 0.915838867915258 0.643479704061859 0.86145293898923 GO:0003785 actin monomer binding 1/653 29/18639 0.0344827586206897 0.98426361092042 0.644774910378996 0.86145293898923 GO:0004181 metallocarboxypeptidase activity 1/653 29/18639 0.0344827586206897 0.98426361092042 0.644774910378996 0.86145293898923 GO:0016417 S-acyltransferase activity 1/653 29/18639 0.0344827586206897 0.98426361092042 0.644774910378996 0.86145293898923 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/653 29/18639 0.0344827586206897 0.98426361092042 0.644774910378996 0.86145293898923 GO:0051861 glycolipid binding 1/653 29/18639 0.0344827586206897 0.98426361092042 0.644774910378996 0.86145293898923 GO:0005507 copper ion binding 2/653 63/18639 0.0317460317460317 0.906147451323562 0.652880141155907 0.8674996056698 GO:0008187 poly-pyrimidine tract binding 1/653 30/18639 0.0333333333333333 0.95145482388974 0.657239283486063 0.8674996056698 GO:0016769 transferase activity, transferring nitrogenous groups 1/653 30/18639 0.0333333333333333 0.95145482388974 0.657239283486063 0.8674996056698 GO:0031210 phosphatidylcholine binding 1/653 30/18639 0.0333333333333333 0.95145482388974 0.657239283486063 0.8674996056698 GO:0032452 histone demethylase activity 1/653 30/18639 0.0333333333333333 0.95145482388974 0.657239283486063 0.8674996056698 GO:0051721 protein phosphatase 2A binding 1/653 30/18639 0.0333333333333333 0.95145482388974 0.657239283486063 0.8674996056698 GO:0016407 acetyltransferase activity 3/653 96/18639 0.03125 0.891988897396631 0.658564165810524 0.8674996056698 GO:0019902 phosphatase binding 6/653 190/18639 0.0315789473684211 0.901378254211332 0.658613400399485 0.8674996056698 GO:0004674 protein serine/threonine kinase activity 14/653 433/18639 0.0323325635103926 0.922889205620533 0.658833644354842 0.8674996056698 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/653 128/18639 0.03125 0.891988897396631 0.660411087878011 0.868180868334014 GO:0016878 acid-thiol ligase activity 1/653 31/18639 0.032258064516129 0.920762732796522 0.669266944718994 0.874209932575528 GO:0070273 phosphatidylinositol-4-phosphate binding 1/653 31/18639 0.032258064516129 0.920762732796522 0.669266944718994 0.874209932575528 GO:0070325 lipoprotein particle receptor binding 1/653 31/18639 0.032258064516129 0.920762732796522 0.669266944718994 0.874209932575528 GO:0140457 protein demethylase activity 1/653 31/18639 0.032258064516129 0.920762732796522 0.669266944718994 0.874209932575528 GO:0005543 phospholipid binding 16/653 497/18639 0.0321931589537223 0.918910091483048 0.671451370901558 0.875275786478645 GO:0042626 ATPase-coupled transmembrane transporter activity 3/653 98/18639 0.0306122448979592 0.87378504234772 0.672220353718031 0.875275786478645 GO:0008235 metalloexopeptidase activity 2/653 66/18639 0.0303030303030303 0.864958930808854 0.677837719331581 0.876784792788773 GO:0031072 heat shock protein binding 4/653 131/18639 0.0305343511450382 0.871561670738693 0.678123357197068 0.876784792788773 GO:0031369 translation initiation factor binding 1/653 32/18639 0.03125 0.891988897396631 0.680873172422051 0.876784792788773 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/653 32/18639 0.03125 0.891988897396631 0.680873172422051 0.876784792788773 GO:0071813 lipoprotein particle binding 1/653 32/18639 0.03125 0.891988897396631 0.680873172422051 0.876784792788773 GO:0071814 protein-lipid complex binding 1/653 32/18639 0.03125 0.891988897396631 0.680873172422051 0.876784792788773 GO:0140142 nucleocytoplasmic carrier activity 1/653 32/18639 0.03125 0.891988897396631 0.680873172422051 0.876784792788773 GO:0005179 hormone activity 4/653 132/18639 0.0303030303030303 0.864958930808854 0.683882463763162 0.877899275583119 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/653 132/18639 0.0303030303030303 0.864958930808854 0.683882463763162 0.877899275583119 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/653 33/18639 0.0303030303030303 0.864958930808854 0.69207271121973 0.884255148968734 GO:0030296 protein tyrosine kinase activator activity 1/653 33/18639 0.0303030303030303 0.864958930808854 0.69207271121973 0.884255148968734 GO:0140416 transcription regulator inhibitor activity 1/653 33/18639 0.0303030303030303 0.864958930808854 0.69207271121973 0.884255148968734 GO:0005548 phospholipid transporter activity 2/653 68/18639 0.0294117647058824 0.839518962255653 0.693650294600253 0.884890329092846 GO:0051087 protein-folding chaperone binding 4/653 134/18639 0.0298507462686567 0.852049096020662 0.69518243276597 0.885465649199579 GO:0015020 glucuronosyltransferase activity 1/653 34/18639 0.0294117647058824 0.839518962255653 0.702879790633549 0.891112304224267 GO:0030332 cyclin binding 1/653 34/18639 0.0294117647058824 0.839518962255653 0.702879790633549 0.891112304224267 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/653 34/18639 0.0294117647058824 0.839518962255653 0.702879790633549 0.891112304224267 GO:0000175 3'-5'-RNA exonuclease activity 1/653 35/18639 0.0285714285714286 0.815532706191205 0.713308143050442 0.898768260243556 GO:0005154 epidermal growth factor receptor binding 1/653 35/18639 0.0285714285714286 0.815532706191205 0.713308143050442 0.898768260243556 GO:0016229 steroid dehydrogenase activity 1/653 35/18639 0.0285714285714286 0.815532706191205 0.713308143050442 0.898768260243556 GO:0140566 histone reader activity 1/653 35/18639 0.0285714285714286 0.815532706191205 0.713308143050442 0.898768260243556 GO:0140299 molecular sensor activity 2/653 71/18639 0.028169014084507 0.804046330047667 0.716161623733814 0.900977526632862 GO:0070851 growth factor receptor binding 4/653 139/18639 0.0287769784172662 0.821399847962365 0.722158600157449 0.907128671056672 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/653 268/18639 0.0298507462686567 0.852049096020662 0.726062461223666 0.910635766833357 GO:0140030 modification-dependent protein binding 5/653 173/18639 0.0289017341040462 0.824960829962202 0.729081886686058 0.913024564519696 GO:0043539 protein serine/threonine kinase activator activity 2/653 73/18639 0.0273972602739726 0.782017663471019 0.730384856037483 0.91325984289267 GO:0042805 actinin binding 1/653 37/18639 0.027027027027027 0.771449857207897 0.733081214219308 0.914593613349732 GO:0003823 antigen binding 5/653 174/18639 0.028735632183908 0.820219675767017 0.733684986533302 0.914593613349732 GO:0005516 calmodulin binding 6/653 207/18639 0.0289855072463768 0.827352020773687 0.736558078299117 0.915364118546884 GO:0035064 methylated histone binding 2/653 74/18639 0.027027027027027 0.771449857207897 0.737266913498557 0.915364118546884 GO:0000146 microfilament motor activity 1/653 38/18639 0.0263157894736842 0.75114854517611 0.742451065155486 0.915364118546884 GO:0005501 retinoid binding 1/653 38/18639 0.0263157894736842 0.75114854517611 0.742451065155486 0.915364118546884 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/653 38/18639 0.0263157894736842 0.75114854517611 0.742451065155486 0.915364118546884 GO:0019840 isoprenoid binding 1/653 38/18639 0.0263157894736842 0.75114854517611 0.742451065155486 0.915364118546884 GO:0042887 amide transmembrane transporter activity 1/653 38/18639 0.0263157894736842 0.75114854517611 0.742451065155486 0.915364118546884 GO:0004518 nuclease activity 6/653 209/18639 0.0287081339712919 0.819434776555757 0.744835662552857 0.915364118546884 GO:0019903 protein phosphatase binding 4/653 144/18639 0.0277777777777778 0.792879019908116 0.747325721066201 0.915364118546884 GO:0140034 methylation-dependent protein binding 2/653 76/18639 0.0263157894736842 0.75114854517611 0.750582026450689 0.915364118546884 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/653 39/18639 0.0256410256410256 0.731888326069031 0.751492485211046 0.915364118546884 GO:0005319 lipid transporter activity 5/653 178/18639 0.0280898876404494 0.801787772940792 0.751528120622108 0.915364118546884 GO:0003724 RNA helicase activity 2/653 77/18639 0.025974025974026 0.741393369264732 0.757019260872656 0.915364118546884 GO:0004177 aminopeptidase activity 1/653 40/18639 0.025 0.713591117917305 0.760216969466809 0.915364118546884 GO:0004532 RNA exonuclease activity 1/653 40/18639 0.025 0.713591117917305 0.760216969466809 0.915364118546884 GO:0032451 demethylase activity 1/653 40/18639 0.025 0.713591117917305 0.760216969466809 0.915364118546884 GO:0050997 quaternary ammonium group binding 1/653 40/18639 0.025 0.713591117917305 0.760216969466809 0.915364118546884 GO:0001217 DNA-binding transcription repressor activity 8/653 278/18639 0.0287769784172662 0.821399847962365 0.762126008553391 0.915364118546884 GO:0017080 sodium channel regulator activity 1/653 41/18639 0.024390243902439 0.696186456504688 0.768635611272184 0.915364118546884 GO:0042287 MHC protein binding 1/653 41/18639 0.024390243902439 0.696186456504688 0.768635611272184 0.915364118546884 GO:0008186 ATP-dependent activity, acting on RNA 2/653 79/18639 0.0253164556962025 0.722623916878283 0.76946379907248 0.915364118546884 GO:0035401 histone H3Y41 kinase activity 3/653 115/18639 0.0260869565217391 0.744616818696318 0.772209359470021 0.915364118546884 GO:0140801 histone H2AXY142 kinase activity 3/653 115/18639 0.0260869565217391 0.744616818696318 0.772209359470021 0.915364118546884 GO:0004402 histone acetyltransferase activity 1/653 42/18639 0.0238095238095238 0.679610588492671 0.776759116264079 0.915364118546884 GO:0019894 kinesin binding 1/653 42/18639 0.0238095238095238 0.679610588492671 0.776759116264079 0.915364118546884 GO:0031492 nucleosomal DNA binding 1/653 42/18639 0.0238095238095238 0.679610588492671 0.776759116264079 0.915364118546884 GO:0051879 Hsp90 protein binding 1/653 42/18639 0.0238095238095238 0.679610588492671 0.776759116264079 0.915364118546884 GO:0000510 H3-H4 histone complex chaperone activity 4/653 151/18639 0.0264900662251656 0.756123038852773 0.779581633475496 0.915364118546884 GO:0140584 chromatin extrusion motor activity 4/653 151/18639 0.0264900662251656 0.756123038852773 0.779581633475496 0.915364118546884 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 4/653 151/18639 0.0264900662251656 0.756123038852773 0.779581633475496 0.915364118546884 GO:0140849 ATP-dependent H2AZ histone chaperone activity 4/653 151/18639 0.0264900662251656 0.756123038852773 0.779581633475496 0.915364118546884 GO:0033192 calmodulin-dependent protein phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0140791 histone H2AXS140 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/653 81/18639 0.0246913580246914 0.704781351029437 0.781349702808504 0.915364118546884 GO:0035091 phosphatidylinositol binding 8/653 284/18639 0.028169014084507 0.804046330047667 0.782075520207986 0.915364118546884 GO:1990782 protein tyrosine kinase binding 3/653 117/18639 0.0256410256410256 0.731888326069031 0.78215393741468 0.915364118546884 GO:0015616 DNA translocase activity 4/653 152/18639 0.0263157894736842 0.75114854517611 0.783912541410442 0.915364118546884 GO:0140674 ATP-dependent histone chaperone activity 4/653 152/18639 0.0263157894736842 0.75114854517611 0.783912541410442 0.915364118546884 GO:0005245 voltage-gated calcium channel activity 1/653 43/18639 0.0232558139534884 0.663805691085865 0.784597815897329 0.915364118546884 GO:0008375 acetylglucosaminyltransferase activity 1/653 43/18639 0.0232558139534884 0.663805691085865 0.784597815897329 0.915364118546884 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/653 82/18639 0.024390243902439 0.696186456504688 0.787088720637406 0.915625210917501 GO:0033549 MAP kinase phosphatase activity 2/653 82/18639 0.024390243902439 0.696186456504688 0.787088720637406 0.915625210917501 GO:0061775 cohesin loader activity 4/653 153/18639 0.0261437908496732 0.74623907756058 0.788175547859388 0.915625210917501 GO:0001046 core promoter sequence-specific DNA binding 1/653 44/18639 0.0227272727272727 0.648719198106641 0.792161680503645 0.91567985871135 GO:0016790 thiolester hydrolase activity 1/653 44/18639 0.0227272727272727 0.648719198106641 0.792161680503645 0.91567985871135 GO:0043014 alpha-tubulin binding 1/653 44/18639 0.0227272727272727 0.648719198106641 0.792161680503645 0.91567985871135 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/653 83/18639 0.0240963855421687 0.687798667872101 0.792694773902744 0.91567985871135 GO:0004386 helicase activity 4/653 155/18639 0.0258064516129032 0.736610186237218 0.796499890104265 0.918779450697736 GO:0017018 myosin phosphatase activity 2/653 84/18639 0.0238095238095238 0.679610588492671 0.798170118047835 0.91941114863738 GO:0030291 protein serine/threonine kinase inhibitor activity 1/653 46/18639 0.0217391304347826 0.620514015580265 0.806503055530642 0.924105273433424 GO:0140658 ATP-dependent chromatin remodeler activity 4/653 158/18639 0.0253164556962025 0.722623916878283 0.808490280281445 0.924105273433424 GO:0050660 flavin adenine dinucleotide binding 2/653 86/18639 0.0232558139534884 0.663805691085865 0.808737724567426 0.924105273433424 GO:0043495 protein-membrane adaptor activity 1/653 47/18639 0.0212765957446809 0.607311589716855 0.813298812252983 0.924105273433424 GO:0061733 protein-lysine-acetyltransferase activity 1/653 47/18639 0.0212765957446809 0.607311589716855 0.813298812252983 0.924105273433424 GO:0003730 mRNA 3'-UTR binding 7/653 262/18639 0.0267175572519084 0.762616461896356 0.815790958673766 0.924105273433424 GO:0003689 DNA clamp loader activity 4/653 160/18639 0.025 0.713591117917305 0.816159729205193 0.924105273433424 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/653 48/18639 0.0208333333333333 0.594659264931087 0.819856249623831 0.924105273433424 GO:0005004 GPI-linked ephrin receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0005008 hepatocyte growth factor receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0005009 insulin receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0005011 macrophage colony-stimulating factor receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0005020 stem cell factor receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0008288 boss receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0036332 placental growth factor receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0038062 protein tyrosine kinase collagen receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0060175 brain-derived neurotrophic factor receptor activity 1/653 49/18639 0.0204081632653061 0.582523361565147 0.826183712858495 0.924105273433424 GO:0004519 endonuclease activity 3/653 127/18639 0.0236220472440945 0.674259324016351 0.826620671854817 0.924105273433424 GO:0019783 ubiquitin-like protein peptidase activity 3/653 127/18639 0.0236220472440945 0.674259324016351 0.826620671854817 0.924105273433424 GO:0031490 chromatin DNA binding 3/653 128/18639 0.0234375 0.668991673047473 0.830609701870261 0.924105273433424 GO:0140713 histone chaperone activity 4/653 164/18639 0.024390243902439 0.696186456504688 0.830742296777533 0.924105273433424 GO:0005006 epidermal growth factor receptor activity 1/653 50/18639 0.02 0.570872894333844 0.83228925538154 0.924105273433424 GO:0005007 fibroblast growth factor receptor activity 1/653 50/18639 0.02 0.570872894333844 0.83228925538154 0.924105273433424 GO:0005017 platelet-derived growth factor receptor activity 1/653 50/18639 0.02 0.570872894333844 0.83228925538154 0.924105273433424 GO:0005019 platelet-derived growth factor beta-receptor activity 1/653 50/18639 0.02 0.570872894333844 0.83228925538154 0.924105273433424 GO:0140097 catalytic activity, acting on DNA 9/653 336/18639 0.0267857142857143 0.764561912054255 0.83654742794451 0.924105273433424 GO:0046982 protein heterodimerization activity 10/653 369/18639 0.02710027100271 0.773540507227431 0.836689260691561 0.924105273433424 GO:0005010 insulin-like growth factor receptor activity 1/653 51/18639 0.0196078431372549 0.559679308170435 0.83818064901411 0.924105273433424 GO:0005021 vascular endothelial growth factor receptor activity 1/653 51/18639 0.0196078431372549 0.559679308170435 0.83818064901411 0.924105273433424 GO:0005030 neurotrophin receptor activity 1/653 51/18639 0.0196078431372549 0.559679308170435 0.83818064901411 0.924105273433424 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/653 130/18639 0.0230769230769231 0.658699493462128 0.838351914726537 0.924105273433424 GO:0005096 GTPase activator activity 7/653 271/18639 0.025830258302583 0.737289715929319 0.841296745903111 0.926104885611086 GO:0042562 hormone binding 2/653 94/18639 0.0212765957446809 0.607311589716855 0.846230914980613 0.926255986476019 GO:0005003 ephrin receptor activity 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0005005 transmembrane-ephrin receptor activity 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0005246 calcium channel regulator activity 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0017046 peptide hormone binding 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0034212 protein N-acetyltransferase activity 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0038064 collagen receptor activity 1/653 53/18639 0.0188679245283019 0.538559334277211 0.849350727525629 0.926255986476019 GO:0004896 cytokine receptor activity 2/653 96/18639 0.0208333333333333 0.594659264931087 0.85449884257857 0.930631053287033 GO:0044325 transmembrane transporter binding 3/653 136/18639 0.0220588235294118 0.62963922169174 0.859770340515175 0.935128697054354 GO:0030170 pyridoxal phosphate binding 1/653 56/18639 0.0178571428571429 0.509707941369503 0.864678895807943 0.939220179929318 GO:0042393 histone binding 6/653 247/18639 0.0242914979757085 0.693367887854871 0.867843807810167 0.941409375624538 GO:0070279 vitamin B6 binding 1/653 57/18639 0.0175438596491228 0.500765696784073 0.86943403120252 0.941886867136063 GO:0004713 protein tyrosine kinase activity 3/653 140/18639 0.0214285714285714 0.611649529643404 0.872630156380852 0.944100525859865 GO:0008238 exopeptidase activity 2/653 102/18639 0.0196078431372549 0.559679308170435 0.876924977509796 0.946268241498183 GO:0030695 GTPase regulator activity 13/653 489/18639 0.0265848670756646 0.758829000648259 0.879129090666541 0.946268241498183 GO:0015291 secondary active transmembrane transporter activity 7/653 287/18639 0.024390243902439 0.696186456504688 0.87960848811307 0.946268241498183 GO:0004722 protein serine/threonine phosphatase activity 2/653 103/18639 0.0194174757281553 0.55424552847946 0.880337542825092 0.946268241498183 GO:0060589 nucleoside-triphosphatase regulator activity 13/653 490/18639 0.026530612244898 0.757280370034691 0.880793138488109 0.946268241498183 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/653 60/18639 0.0166666666666667 0.47572741194487 0.882721534193666 0.946268241498183 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/653 60/18639 0.0166666666666667 0.47572741194487 0.882721534193666 0.946268241498183 GO:0015026 coreceptor activity 1/653 61/18639 0.0163934426229508 0.467928601912987 0.886843544967741 0.948619055609371 GO:0008194 UDP-glycosyltransferase activity 3/653 145/18639 0.0206896551724138 0.590558166552252 0.887231009275676 0.948619055609371 GO:0004497 monooxygenase activity 2/653 106/18639 0.0188679245283019 0.538559334277211 0.890057528573091 0.950400411866182 GO:0015085 calcium ion transmembrane transporter activity 3/653 147/18639 0.0204081632653061 0.582523361565147 0.892640302256037 0.951917197327727 GO:1901682 sulfur compound transmembrane transporter activity 1/653 63/18639 0.0158730158730159 0.453073725661781 0.894658646700616 0.95282890981509 GO:0004620 phospholipase activity 2/653 109/18639 0.018348623853211 0.523736600306279 0.899040706396766 0.956252387712924 GO:0160215 deacylase activity 1/653 65/18639 0.0153846153846154 0.439132995641418 0.901934771118255 0.958086352199547 GO:0005200 structural constituent of cytoskeleton 2/653 112/18639 0.0178571428571429 0.509707941369503 0.907336252929438 0.9618258015564 GO:0016500 protein-hormone receptor activity 1/653 67/18639 0.0149253731343284 0.426024548010331 0.908709036331946 0.9618258015564 GO:0000287 magnesium ion binding 5/653 230/18639 0.0217391304347826 0.620514015580265 0.908978230042312 0.9618258015564 GO:0003777 microtubule motor activity 1/653 68/18639 0.0147058823529412 0.419759481127826 0.911918868298091 0.963692326627273 GO:0140375 immune receptor activity 3/653 156/18639 0.0192307692307692 0.548916244551773 0.914207365916957 0.964449939446531 GO:0101005 deubiquitinase activity 2/653 115/18639 0.0173913043478261 0.496411212464212 0.914990968192863 0.964449939446531 GO:0015294 solute:monoatomic cation symporter activity 2/653 116/18639 0.0172413793103448 0.49213180546021 0.917407876075953 0.964994633090912 GO:0016758 hexosyltransferase activity 4/653 197/18639 0.0203045685279188 0.579566390186643 0.917864248080367 0.964994633090912 GO:0004540 RNA nuclease activity 2/653 121/18639 0.0165289256198347 0.471795780441193 0.928553103463453 0.9741431922674 GO:0003678 DNA helicase activity 1/653 74/18639 0.0135135135135135 0.385724928603949 0.928944851234236 0.9741431922674 GO:0019199 transmembrane receptor protein kinase activity 1/653 78/18639 0.0128205128205128 0.365944163034515 0.938427477870124 0.982020418857454 GO:0008094 ATP-dependent activity, acting on DNA 4/653 210/18639 0.019047619047619 0.543688470794137 0.939304446120238 0.982020418857454 GO:0042826 histone deacetylase binding 2/653 127/18639 0.015748031496063 0.449506216010901 0.940053734290896 0.982020418857454 GO:0015101 organic cation transmembrane transporter activity 1/653 81/18639 0.0123456790123457 0.352390675514718 0.944700458742201 0.984803613099003 GO:0016298 lipase activity 2/653 130/18639 0.0153846153846154 0.439132995641418 0.945122881435673 0.984803613099003 GO:0005262 calcium channel activity 2/653 131/18639 0.0152671755725191 0.435780835369346 0.946720022674309 0.985214356506047 GO:0005254 chloride channel activity 1/653 83/18639 0.0120481927710843 0.34389933393605 0.948523740093404 0.985838760325505 GO:0001664 G protein-coupled receptor binding 6/653 297/18639 0.0202020202020202 0.576639287205903 0.950968234062565 0.987126722049735 GO:0140789 histone phosphatase activity 2/653 136/18639 0.0147058823529412 0.419759481127826 0.954063271470155 0.9890858472583 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/653 89/18639 0.0112359550561798 0.320715109176317 0.958481384359416 0.990167832468996 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/653 89/18639 0.0112359550561798 0.320715109176317 0.958481384359416 0.990167832468996 GO:0016757 glycosyltransferase activity 5/653 267/18639 0.0187265917602996 0.534525181960528 0.959477144158991 0.990167832468996 GO:0140793 histone H2AXY142 phosphatase activity 1/653 90/18639 0.0111111111111111 0.317151607963247 0.959942929157977 0.990167832468996 GO:0005085 guanyl-nucleotide exchange factor activity 4/653 230/18639 0.0173913043478261 0.496411212464212 0.962512579995738 0.991569563542779 GO:0015293 symporter activity 2/653 146/18639 0.0136986301369863 0.391008831735509 0.965951825830083 0.99386249416437 GO:0008509 monoatomic anion transmembrane transporter activity 2/653 149/18639 0.0134228187919463 0.383136170693855 0.968899438032811 0.995454076323251 GO:0004725 protein tyrosine phosphatase activity 1/653 98/18639 0.0102040816326531 0.291261680782573 0.969929612827783 0.995454076323251 GO:0042578 phosphoric ester hydrolase activity 7/653 363/18639 0.0192837465564738 0.550428410514725 0.972648527267767 0.996995173757574 GO:0005253 monoatomic anion channel activity 1/653 103/18639 0.00970873786407767 0.27712276423973 0.974865304439401 0.998018355419837 GO:0004843 cysteine-type deubiquitinase activity 1/653 108/18639 0.00925925925925926 0.264293006636039 0.978991896358862 0.999989243464977 GO:0016887 ATP hydrolysis activity 8/653 417/18639 0.0191846522781775 0.547599898641577 0.980201396580672 0.999989243464977 GO:0004721 phosphoprotein phosphatase activity 2/653 175/18639 0.0114285714285714 0.326213082476482 0.985978898688846 0.999989243464977 GO:0008514 organic anion transmembrane transporter activity 4/653 269/18639 0.0148698884758364 0.424440813631111 0.98604836451753 0.999989243464977 GO:0045182 translation regulator activity 6/653 356/18639 0.0168539325842697 0.481072663764475 0.986796827882805 0.999989243464977 GO:0015108 chloride transmembrane transporter activity 1/653 121/18639 0.00826446280991736 0.235897890220597 0.986824076904985 0.999989243464977 GO:0016791 phosphatase activity 4/653 273/18639 0.0146520146520147 0.418221900610875 0.98743339283972 0.999989243464977 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/653 130/18639 0.00769230769230769 0.219566497820709 0.990462585708554 0.999989243464977 GO:0022843 voltage-gated monoatomic cation channel activity 1/653 143/18639 0.00699300699300699 0.199605907109736 0.994021674315283 0.999989243464977 GO:0046873 metal ion transmembrane transporter activity 7/653 450/18639 0.0155555555555556 0.444012251148545 0.996157552056426 0.999989243464977 GO:0015079 potassium ion transmembrane transporter activity 1/653 160/18639 0.00625 0.178397779479326 0.996755904490602 0.999989243464977 GO:0015081 sodium ion transmembrane transporter activity 1/653 164/18639 0.00609756097560976 0.174046614126172 0.997190751145372 0.999989243464977 GO:0015103 inorganic anion transmembrane transporter activity 1/653 165/18639 0.00606060606060606 0.172991786161771 0.997290044217203 0.999989243464977 GO:0005244 voltage-gated monoatomic ion channel activity 1/653 173/18639 0.00578034682080925 0.16499216599244 0.997968077561741 0.999989243464977 GO:0022832 voltage-gated channel activity 1/653 175/18639 0.00571428571428571 0.163106541238241 0.998109247264649 0.999989243464977 GO:0005261 monoatomic cation channel activity 3/653 341/18639 0.00879765395894428 0.251117108944506 0.99956664835418 0.999989243464977 GO:0030371 translation repressor activity 2/653 329/18639 0.0060790273556231 0.173517597061959 0.999905001517025 0.999989243464977 GO:0005216 monoatomic ion channel activity 4/653 448/18639 0.00892857142857143 0.254853970684752 0.999913016009378 0.999989243464977 GO:0022836 gated channel activity 1/653 318/18639 0.00314465408805031 0.0897598890462019 0.999989243464977 0.999989243464977