category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	95/444	238/9376	8.42910137027784	RPL10/CFD/RPL18A/RPL3/RPL6/RPL29/RPL12/RPS4X/RPS2/RPL7A/RPL13A/RPL37A/RPS20/RPL15/RPS27/RPS5/RPL10A/RPS29/RPLP0/RPL5/RPL27A/RPL23A/RPS16/RPL14/FOS/RPS23/RPS9/RPS6/RPS18/RPSA/RPS11/RPL31/RPL17/RPL37/RPL30/RPS13/RPL9/RPL8/C1S/RPS3/RPS25/RPL18/RPL11/RPL4/RPS14/RPS27A/RPL34/RPL22/RPL7/RPL26/RPL39/RPL19/RPL32/RPS15A/RPL24/RPS19/RPS3A/NFKBIA/RPS17/RPS26/RPS8/RPL41/RPL23/RPL28/ACE2/RPS21/RPS28/CXCL8/NRP1/RPL13/RPL21/RPS7/NFKB1/RPL27/C2/RPLP2/RPL36/UBA52/SYK/RPL35A/RPS12/JUN/RPS24/RPS15/RPL36A/C1R/AGTR1/C1QC/RPLP1/JAK1/FAU/FCGR2A/IL6/F13A1/TLR2	25.8822454872323
Genetic Information Processing	Translation	hsa03010	Ribosome	79/444	222/9376	7.51464978492005	RPL10/RPL18A/RPL3/RPL6/RPL29/RPL12/RPS4X/RPS2/RPL7A/RPL13A/RPL37A/RPS20/RPL15/RACK1/RPS27/RPS5/RPL10A/RPS29/RPLP0/RPL5/RPL27A/RPL23A/RPS16/RPL14/RPS23/RPS9/RPS6/RPS18/RPSA/RPS11/RPL31/RPL17/RPL37/RPL30/RPS13/RPL9/RPL8/RPS3/RPS25/RPL18/RPL11/RPL4/RPS14/RPS27A/RPL34/RPL22/RPL7/RPL26/RPL39/MRPS24/RPL19/RPL32/RPS15A/RPL24/RPS19/RPS3A/RPS17/RPS26/RPS8/RPL41/RPL23/RPL28/RPS21/RPS28/RPL13/RPL21/RPS7/RPL27/RPLP2/RPL36/UBA52/RPL35A/RPS12/RPS24/RPS15/RPL36A/RPLP1/FAU/MRPL51	21.9010467924921
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	30/444	233/9376	2.71894211808375	COL6A1/COL6A2/COL1A2/FBLN1/COL6A3/ACTG1/COL3A1/LAMA2/ITGAV/VIM/FN1/DIAPH2/VCAN/THBS2/COL1A1/TPM4/ITGB1/SYNPO2/ENO1/FBLN2/SSPN/LMNA/TPM2/ACTB/SYNE1/LMNB1/ITGA5/MYH11/ENO2/VCL	5.92376224758273
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/444	248/9376	2.63963963963964	ACTG1/FOS/RPS3/PAK3/GAPDH/TUBB3/ANXA2/NFKBIA/MYC/FLNA/CXCL8/NFKB1/MYL12B/TUBB4B/RAB7B/HSP90AB1/JUN/TXN/ARPC2/PFN1/ACTB/PLEKHM2/TUBB2A/NAIP/TNFRSF10B/IL6/AHNAK2/CYFIP1/TLR2/SNX9/NCKAP1L	5.83430595340101
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/444	89/9376	3.7963356615042	COL6A1/CD44/COL6A2/COL1A2/COL6A3/LAMB1/LAMA2/TNXB/ITGAV/FN1/THBS2/COL1A1/ITGB1/GP1BB/SPP1/ITGA5	5.9094810981333
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/444	103/9376	3.485349427097	COL1A2/LAMB1/COL3A1/LAMA2/FN1/COL1A1/PRDX1/CXCL8/NFKB1/RAB7B/SERPINB6/CXCL1/HSPB1/TGFB1/IL6/TLR2/VCL	5.65455855112453
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	25/444	200/9376	2.63963963963964	ACTG1/FOS/RPS3/PAK3/GAPDH/TUBB3/NFKBIA/ITGB1/CXCL8/NFKB1/TUBB4B/PTPN11/JUN/ARPC2/ACTB/NCL/TUBB2A/NAIP/TNFRSF10B/FCGR2A/MYH11/IL6/CYFIP1/SEC24A/NCKAP1L	5.22563979829639
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/444	78/9376	3.79025179025179	FOS/CALM1/C1S/ITGB1/CXCL8/NFKB1/C2/JUN/CFL1/C1R/IRF8/C1QC/ITGA5/IL6	5.51694547712624
NA	NA	hsa04518	Integrin signaling	20/444	154/9376	2.74248274248274	COL6A1/COL6A2/COL1A2/COL6A3/ACTG1/LAMB1/LAMA2/TNXB/ITGAV/FN1/THBS2/COL1A1/ITGB1/FLNA/ITGAX/ACTB/SPP1/ITGA5/TGFB1/VCL	4.86092648588064
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/444	155/9376	2.72478930543447	ACTG1/ITGAV/THBS2/TUBB3/ITGB1/HLA-C/TUBB4B/RAB7B/C1R/ACTB/TUBB2A/SEC61B/HLA-DQB1/HLA-B/ITGA5/FCGR2A/HLA-DQB2/CALR/OLR1/TLR2	4.82742632939386
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/444	56/9376	4.14800514800515	EEF1A1/EEF1G/NFKBIA/CXCL8/NFKB1/VCP/CXCL1/HSPA8/NAIP/IL6/TLR2	5.26773910181531
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/444	204/9376	2.38085143967497	CD44/COL1A2/ACTG1/ITGAV/RPS6/FN1/CAV1/DDX5/COL1A1/ITGB1/MYC/HPSE2/FLNA/PTPN11/HSPB2/EIF4B/ACTB/TWIST2/TWIST1/ITGA5/TGFB1/CDKN1A/TLR2	4.44562456773693
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	34/444	362/9376	1.9833756408342	COL6A1/COL6A2/COL1A2/COL6A3/LAMB1/LAMA2/TNXB/GNG4/ITGAV/RPS6/FN1/THBS2/CSH1/MCL1/COL1A1/FGF10/ITGB1/MYC/YWHAQ/NFKB1/SYK/FGF7/HSP90AB1/YWHAB/EIF4B/KITLG/JAK1/SPP1/IL2RG/ATF4/ITGA5/CDKN1A/IL6/TLR2	4.25419821124037
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/444	232/9376	2.27555141348245	GSN/ACTG1/TMSB4X/ITGAV/FN1/DIAPH2/PAK3/FGF10/ITGB1/MYL12B/ITGAX/FGF7/CFL1/ARPC2/PFN1/ACTB/BDKRB1/CXCL12/PIP4K2A/ENAH/ITGA5/MYH11/CYFIP1/VCL/NCKAP1L	4.38608070110557
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	22/444	203/9376	2.28855456441663	COL6A1/COL6A2/COL1A2/COL6A3/ACTG1/LAMB1/LAMA2/TNXB/ITGAV/FN1/THBS2/CAV1/PAK3/COL1A1/ITGB1/FLNA/MYL12B/JUN/ACTB/SPP1/ITGA5/VCL	4.1380706571607
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/444	78/9376	3.24878724878725	EEF1A1/FOS/NFKBIA/ITGB1/NFKB1/JUN/HLA-DQB1/JAK1/FCGR2A/TGFB1/HLA-DQB2/TLR2	4.44635021275138
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/444	224/9376	2.16827541827542	EGR1/FOS/SLC25A6/NFKBIA/MYC/NRP1/NFKB1/HLA-C/NFATC1/FOSL1/JUN/RAN/MSX2/HLA-DQB1/JAK1/IL2RG/HLA-B/ATF4/TGFB1/HLA-DQB2/CALR/CDKN1A/IL6	3.94560866143811
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/444	196/9376	2.26254826254826	FOS/GNG4/MAP1LC3B/CALM1/UBC/RPS27A/CLEC2B/NFKBIA/MYC/CXCL8/NFKB1/UBA52/HLA-C/SYK/NFATC1/JUN/CXCL1/JAK1/HLA-B/CDKN1A/IL6	3.98251527036413
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/444	109/9376	2.7122902719233	FOS/RORA/NFKBIA/NFKB1/HSP90AB1/NFATC1/JUN/HLA-DQB1/AHR/JAK1/IL2RG/TGFB1/HLA-DQB2/IL6	4.00888707415681
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/444	99/9376	2.77295477295477	ACTG1/LAMA2/ITGAV/TPM4/ITGB1/SLC8A1/SSPN/LMNA/TPM2/ACTB/ITGA5/TGFB1/IL6	3.95379585885261
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/444	66/9376	3.1995631995632	RORA/NFKB1/NFATC1/JUN/HLA-DQB1/IL2RG/TGFB1/HLA-DQB2/IL6/TLR2	3.99794060996411
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/444	93/9376	2.72478930543447	FOS/NFKBIA/RUNX3/NFKB1/NFATC1/JUN/HLA-DQB1/JAK1/IL2RG/DLL1/DLL3/HLA-DQB2	3.72680024851873
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/444	70/9376	3.01673101673102	ACTG1/LAMA2/ABL2/CAV1/HLA-C/SSPN/ACTB/HLA-DQB1/HLA-B/HLA-DQB2	3.775880486518
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/444	205/9376	2.06020654801143	CD44/VIM/GADD45A/NFKBIA/MYC/RUNX3/NFKB1/HLA-C/SYK/PSMD8/JUN/PDIA3/HLA-DQB1/JAK1/HLA-B/HLA-DQB2/CALR/CDKN1A/IL6/TLR2	3.42185680848739
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/444	101/9376	2.50896440995451	COL1A2/COL3A1/EGR1/FN1/COL1A1/CXCL8/NFKB1/NFATC1/JUN/AGTR1/TGFB1/IL6	3.39926866229488
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/444	105/9376	2.41338481338481	MAP1LC3B/UBC/RPS27A/RABGEF1/UBA52/RAB7B/JUN/VCP/SMURF2/ARIH1/ATF4/OPTN	3.24709164068282
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/444	105/9376	2.41338481338481	ACTG1/LAMA2/ITGAV/TPM4/ITGB1/SLC8A1/SSPN/LMNA/TPM2/ACTB/ITGA5/TGFB1	3.24709164068282
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/444	180/9376	1.99439439439439	PILRA/NFKBIA/SOCS3/NFKB1/HLA-C/PTPN11/SYK/PDIA3/SRSF5/HLA-DQB1/JAK1/HLA-B/ITGA5/HLA-DQB2/CALR/IL6/TLR2	3.00329646383332
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/444	82/9376	2.57525818501428	HLA-C/HSP90AB1/PDIA3/HSPA8/PSME1/HLA-DQB1/HLA-B/KIR2DL3/HLA-DQB2/CALR	3.19418527337039
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/444	138/9376	2.14231622927275	ACTG1/FOS/FN1/NFKBIA/ITGB1/CXCL8/NFKB1/NFATC1/JUN/ARPC2/ACTB/ITGA5/FCGR2A/IL6	3.01397521969037
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/444	173/9376	1.95302817268135	ACTG1/SLC25A6/NFKBIA/SOCS3/CXCL8/NFKB1/KPNA2/ACTB/DNAJB1/HLA-DQB1/JAK1/TRIM25/TNFRSF10B/HLA-DQB2/IL6/DNAJC3	2.8207646066813
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/444	174/9376	1.94180387283836	HSP90AB1/UBXN1/VCP/HERPUD1/PDIA3/OSTC/HSPA8/SSR3/DNAJB1/SEC61B/P4HB/ATF4/CALR/DNAJC3/SSR2/SEC24A	2.79573979123713
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/444	88/9376	2.3996723996724	CFD/SERPINE2/C1S/PROCR/C2/ITGAX/C1R/C1QC/BDKRB1/F13A1	2.94109733441344
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/444	50/9376	2.9563963963964	THBS2/LRP1/CXCL8/TGFB1/GYPC/IL6/TLR2	3.09240891678147
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/444	103/9376	2.25522609988629	COL6A1/COL15A1/COL6A2/COL1A2/COL6A3/COL3A1/COL1A1/COL18A1/ACE2/SLC8A1/COL21A1	2.85583564199149
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/444	163/9376	1.94329298623777	FOS/NFKBIA/MYC/YWHAQ/CXCL8/NFKB1/NFATC1/YWHAB/JUN/JAK1/ATF4/TGFB1/CDKN1A/IL6/TLR2	2.70858605363012
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/444	78/9376	2.43659043659044	ACTG1/FN1/CAV1/ITGB1/ARPC2/ACTB/ITGA5/VCL/CLTA	2.8404573161891
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/444	93/9376	2.27065775452872	LAMB1/LAMA2/ITGAV/FN1/GADD45A/NFKBIA/ITGB1/MYC/NFKB1/CDKN1A	2.74554556921203
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/444	94/9376	2.24650182096991	FOS/NFKBIA/CXCL8/NFKB1/HSP90AB1/FOSL1/JUN/CXCL1/JUND/IL6	2.70793869478716
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/444	109/9376	2.13108521365402	FOS/NFKBIA/CXCL8/NFKB1/JUN/MAP3K8/JAK1/SPP1/CCL4L2/IL6/TLR2	2.6481449828564
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/444	95/9376	2.22285443338075	FOS/CXCL8/JUN/CXCL1/HLA-DQB1/CXCL12/TGFB1/HLA-DQB2/IL6/TLR2	2.67080354965303
NA	NA	hsa04517	IgSF CAM signaling	23/444	299/9376	1.62439362439362	ACTG1/MYL6/PAK3/JAM2/TUBB3/EPB41L3/ITGB1/NRP1/PMP22/APP/MYL12B/TUBB4B/ITGAX/PTPN11/ARPC2/TRIO/ACTB/TUBB2A/MBP/CRTAM/ITGA5/MYH11/VCL	2.44638977218377
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/444	21/9376	4.02230802230802	CHSY3/XYLT1/UST/DSEL	3.09121520850639
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/444	268/9376	1.654699475595	CALM1/SLC25A6/MT-CO3/MT-ND1/UBC/RPS27A/COX4I1/TUBB3/MT-CO1/MT-ATP8/UBA52/PSMA7/TUBB4B/DUSP1/PSMD8/TXN/NDUFS5/PSMB5/TUBB2A/ATF4/MT-ND5	2.42437973501826
Organismal Systems	Immune system	hsa04611	Platelet activation	12/444	126/9376	2.01115401115401	COL1A2/ACTG1/COL3A1/COL1A1/ITGB1/MYL12B/SYK/GP1BB/PRKG1/ACTB/FCGR2A/APBB1IP	2.54761901220646
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/444	112/9376	2.07400257400257	LAMB1/LAMA2/NFKBIA/ITGB1/NFKB1/HSPA8/HLA-DQB1/JAK1/TGFB1/HLA-DQB2/TLR2	2.54928168831409
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/444	142/9376	1.93325720086283	FOS/NFKBIA/SOCS3/NFKB1/SYK/NFATC1/FOSL1/JUN/JUND/JAK1/FCGR2A/TGFB1/TEC1	2.49835042003805
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/444	45/9376	2.81561561561562	HLA-C/HLA-DQB1/HLA-B/KIR2DL3/HLA-DQB2/IL6	2.72187914196125
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/444	86/9376	2.20993086109365	ACTG1/LAMA2/ITGAV/ITGB1/SLC8A1/SSPN/LMNA/ACTB/ITGA5	2.51307059669234
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/444	275/9376	1.61257985257985	EGR1/SLC25A6/MT-CO3/MT-ND1/CAV1/COX4I1/TUBB3/MT-CO1/MT-ATP8/PSMA7/TUBB4B/PRNP/PSMD8/NDUFS5/HSPA8/PSMB5/TUBB2A/C1QC/ATF4/MT-ND5/IL6	2.29872630061116
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/444	227/9376	1.67448505774497	GNG4/ITGAV/CALM1/NFKBIA/MYC/CXCL8/NFKB1/HLA-C/NFATC1/PDIA3/CXCL12/JAK1/HLA-B/ATF4/CALR/CDKN1A/CCL4L2/IL6	2.29351304050588
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/444	103/9376	2.05020554535118	FOS/NFKBIA/CXCL8/NFKB1/JUN/C1QC/TGFB1/CALR/IL6/TLR2	2.38938182380265
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/444	105/9376	2.01115401115401	GADD45A/NFKBIA/CXCL8/NFKB1/SYK/CXCL1/CXCL12/TRIM25/CCL4L2/EDA	2.32301189737431
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/444	137/9376	1.84967449201026	ACTG1/FOS/GADD45A/MCL1/NFKBIA/NFKB1/JUN/LMNA/ACTB/LMNB1/TNFRSF10B/ATF4	2.23358840592606
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/444	205/9376	1.64816523840914	COL1A2/COL3A1/GFPT2/SLC25A6/MT-CO3/MT-ND1/COX4I1/COL1A1/GAPDH/MT-CO1/MT-ATP8/NFKB1/NDUFS5/AGTR1/TGFB1/MT-ND5	2.0919778681194
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/444	157/9376	1.74855109886957	CALM1/SLC25A6/GADD45A/MYC/CXCL8/NFKB1/HLA-C/NFATC1/ZFP36L2/HLA-B/TGFB1/CDKN1A/IL6	2.108784190416
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/444	157/9376	1.74855109886957	FOS/MT-CO3/COX4I1/MT-CO1/SOCS3/CXCL8/NFKB1/JUN/NDUFS5/MLXIP/ATF4/TGFB1/IL6	2.108784190416
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/444	142/9376	1.78454510848877	ACTG1/FOS/ITGAV/CALM1/CAV1/NFKB1/DUSP1/HSP90AB1/JUN/TXN/ACTB/GSTM1	2.10024481945551
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/444	227/9376	1.58145811009247	CYP1B1/FOS/ABL2/SLC25A6/MT-CO3/MT-ND1/COX4I1/MT-CO1/NFKBIA/MT-ATP8/NFKB1/PTPN11/JUN/NDUFS5/GSTM1/AHR/MT-ND5	1.97718502832902
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/444	98/9376	1.93932708218423	GSN/SYK/BIN1/CFL1/ARPC2/MARCKS/AMPH/ASAP1/FCGR2A	2.08403718483438
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/444	71/9376	2.0819692932369	JAM2/NFKBIA/CXCL8/NFKB1/PTPN11/JUN/CXCL1	2.04027490172774
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/444	250/9376	1.52043243243243	CAV1/IQSEC1/HLA-C/CHMP4B/BIN1/ARPC2/HSPA8/VPS28/SMURF2/ARF5/PSD3/AMPH/IL2RG/HLA-B/ASAP1/IQSEC3/AP2M1/CLTA	1.85950303432789
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/444	217/9376	1.55702246024827	CYP1B1/FOS/FGF10/MYC/NFKB1/FGF7/HSP90AB1/JUN/KPNA2/KLF4/GSTM1/AHR/PTGES3/DLL1/ATF4/DLL3	1.85089299006504
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/444	253/9376	1.50240358936011	CD44/ACTG1/MAP1LC3B/UBC/RPS27A/NFKBIA/ITGB1/CXCL8/NFKB1/UBA52/MYL12B/JUN/ARPC2/PFN1/ACTB/NAIP/ITGA5/VCL	1.80612133463212
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/444	308/9376	1.43980343980344	SLC25A6/MT-CO3/MT-ND1/TGM2/COX4I1/TUBB3/MT-CO1/MT-ATP8/PSMA7/TUBB4B/TAF4B/PSMD8/NDUFS5/PSMB5/TUBB2A/IFT57/GRIA3/MT-ND5/POLR2J2/AP2M1/CLTA	1.74977009711246
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/444	90/9376	1.87707707707708	FOS/NFKBIA/NFKB1/PTPN11/NFATC1/JUN/JAK1/TLR2	1.86400658272471
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/444	157/9376	1.6140471681873	ITGAV/DUSP16/PBX1/LRP1/SLC16A1/RAB7B/PTPN11/NFATC1/C1QC/TGFB1/CALR/STAB1	1.72986581998019
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/444	77/9376	1.91973791973792	GADD45A/NFKBIA/MYC/NFKB1/PTPN11/TGFB1/CDKN1A	1.80673349955141
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/444	110/9376	1.72776412776413	LDHA/RPS6/TIMP1/GAPDH/NFKB1/ENO1/CDKN1A/IL6/ENO2	1.711762885136
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/444	50/9376	2.11171171171171	HLA-DQB1/CXCL12/TGFB1/HLA-DQB2/IL6	1.7572447058889
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/444	216/9376	1.46646646646647	FOS/CALM1/NFKBIA/CXCL8/NFKB1/HSP90AB1/NFATC1/JUN/CXCL1/HSPA8/TNFRSF10B/ATF4/IL6/OLR1/TLR2	1.54633053994497
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/444	130/9376	1.62439362439362	COL1A2/COL3A1/FOS/GNG4/COL1A1/NFKBIA/NFKB1/JUN/ATF4/TGFB1	1.59829138127216
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/444	51/9376	2.07030559971736	ACTG1/KDELR2/SLC12A2/ACTB/SEC61B	1.70872129343568
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/444	23/9376	2.75440658049354	ENPEP/ACE2/AGTR1	1.87811190036247
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/444	99/9376	1.70643370643371	CFD/C1S/C2/C1R/C1QC/HLA-DQB1/FCGR2A/HLA-DQB2	1.57538968599665
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/444	184/9376	1.49197023110067	TRPC4/PAK3/ITGB1/NRP1/MYL12B/PTPN11/CFL1/EFNB2/CXCL12/SEMA5A/BOC/ENAH/RHOD	1.5026072996926
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/444	100/9376	1.68936936936937	CD44/GP1BB/CD38/KITLG/HLA-DQB1/ITGA5/HLA-DQB2/IL6	1.54516327939411
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	13/444	187/9376	1.46803487979959	MAP1LC3B/NFKBIA/CXCL8/NFKB1/HSP90AB1/JUN/TXN/CXCL1/NAIP/IFI16/JAK1/IL6/TRPM2	1.44134406174769
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/444	69/9376	1.83627105366236	FOS/CALM1/ARC/JUN/GRIA3/ATF4	1.55442409292244
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/444	136/9376	1.55272919978802	RACK1/FOS/NFKBIA/NFKB1/JUN/HSPA8/JAK1/IL2RG/IL6/TLR2	1.44760022818568
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/444	119/9376	1.59709289121054	FOS/NFKBIA/SOCS3/NFKB1/JUN/MAP3K8/CXCL1/ATF4/IL6	1.46144681637254
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/444	54/9376	1.95528862195529	CGA/HLA-C/HLA-DQB1/HLA-B/HLA-DQB2	1.56956643120398
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/444	39/9376	2.16585816585817	HLA-C/HLA-DQB1/HLA-B/HLA-DQB2	1.62658629615768
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/444	154/9376	1.50836550836551	ACTG1/FOS/CALM1/EEF2/MYL6/NFATC1/JUN/CD38/ACTB/CDKN1A/TRPM2	1.4181646129827
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/444	120/9376	1.58378378378378	CALM1/NFKBIA/NFKB1/PTPN11/IRAK3/JUN/BEX3/SH2B2/ATF4	1.43494000382383
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/444	300/9376	1.33741741741742	FOS/DUSP16/GADD45A/FGF10/MYC/FLNA/NFKB1/DUSP1/FGF7/NFATC1/JUN/MAP3K8/KITLG/HSPB1/HSPA8/JUND/PTPN5/ATF4/TGFB1	1.32429166864096
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/444	122/9376	1.55782011519716	FOS/PAK3/NFKBIA/NFKB1/PTPN11/NFATC1/JUN/MAP3K8/TEC1	1.38264951246493
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/444	105/9376	1.60892320892321	CALM1/NFKBIA/NFKB1/PTPN11/SYK/NFATC1/JUN/IL6	1.3989321540658
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/444	41/9376	2.06020654801143	TYMP/MYC/CXCL8/CDKN1A	1.51679893635569
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/444	214/9376	1.38149364317589	FOS/GNG4/CALM1/PAK3/NFKBIA/NFKB1/HLA-C/NFATC1/JUN/CFL1/PDIA3/HLA-B/CALR/TLR2	1.25864082615375
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/444	75/9376	1.68936936936937	BCAT1/GAPDH/ENO1/PRPS2/TPI1/ENO2	1.3363510466423
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/444	109/9376	1.54988015538474	GFPT2/NFKBIA/SOCS3/NFKB1/PTPN11/MLXIP/SLC27A4/IL6	1.28740289155598
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	28/444	480/9376	1.23183183183183	MAP1LC3B/CALM1/SLC25A6/MT-CO3/MT-ND1/UBC/RPS27A/COX4I1/TUBB3/MT-CO1/MT-ATP8/NFKB1/APP/UBA52/PSMA7/TUBB4B/PRNP/PSMD8/VCP/NDUFS5/PSMB5/TUBB2A/IFT57/GRIA3/ATF4/MT-ND5/OPTN/IL6	1.16251633606709
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/444	110/9376	1.53579033579034	THSD4/MYC/ID4/FMOD/BMP8B/SMURF2/NBL1/TGFB1	1.2602242622732
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/444	181/9376	1.40002986411826	CALM1/NFKB1/ITGAX/SYK/HLA-DQB1/JAK1/FCGR2A/HSPA9/TGFB1/HLA-DQB2/IL6/TLR2	1.21159814956436
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/444	93/9376	1.58946042817011	CST3/CALM1/ATP2B1/CD38/SLC12A2/PRKG1/LYZ	1.27366355025198
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/444	44/9376	1.91973791973792	HLA-C/HLA-DQB1/HLA-B/HLA-DQB2	1.36334519409181
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/444	368/9376	1.26243634939287	ACTG1/MAP1LC3B/HNRNPA1/MT-CO3/MT-ND1/COX4I1/TUBB3/MT-CO1/MT-ATP8/PSMA7/TUBB4B/PSMD8/VCP/NDUFS5/PFN1/ACTB/PSMB5/TUBB2A/ATF4/MT-ND5/OPTN/NUP153	1.14508170116937
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	20/444	333/9376	1.26829532234938	COL6A1/COL6A2/COL1A2/COL6A3/LAMB1/LAMA2/TNXB/ITGAV/FN1/THBS2/COL1A1/ITGB1/NFKB1/HLA-C/CHD4/JAK1/SPP1/HLA-B/ITGA5/CDKN1A	1.11142898436186
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/444	78/9376	1.62439362439362	BTG1/PABPC1/ENO1/PABPC4/HSPA9/ENO2	1.23456441962681
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/444	46/9376	1.83627105366236	PSMA7/PSMD8/PSMB5/PSME1	1.26761661969603
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/444	205/9376	1.33913425620743	GSN/NFKBIA/YWHAQ/NFKB1/HLA-C/SYK/YWHAB/JUN/CHD4/JAK1/HLA-B/ATF4/CDKN1A	1.09456866284341
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/444	170/9376	1.36640169581346	ACTG1/MYL6/RAB13/JAM2/ITGB1/YBX3/MYL12B/JUN/ARPC2/ACTB/MYH11	1.0748533553117
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/444	116/9376	1.45635290462877	ACTG1/JAM2/ITGB1/MYL12B/PTPN11/ACTB/CXCL12/VCL	1.10262309925999
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/444	17/9376	2.48436671966084	PAPSS2/TXNRD1	1.36569497600072
Human Diseases	Immune disease	hsa05310	Asthma	3/444	32/9376	1.97972972972973	PRG2/HLA-DQB1/HLA-DQB2	1.23770637307465
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/444	100/9376	1.4781981981982	CXCL8/CXCL1/CXCL12/IL2RG/TNFRSF10B/CCL4L2/IL6	1.07184091571144
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/444	67/9376	1.57590426247143	LDHA/GAPDH/ENO1/TPI1/ENO2	1.05472428359139
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	22/444	388/9376	1.19736231076437	CALM1/SLC25A6/MT-CO3/MT-ND1/COX4I1/GAPDH/TUBB3/LRP1/MT-CO1/MT-ATP8/RTN4/NFKB1/APP/PSMA7/TUBB4B/PSMD8/NDUFS5/PSMB5/TUBB2A/ATF4/MT-ND5/IL6	0.885220205507014
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/444	87/9376	1.45635290462877	MT-CO3/COX4I1/TPM4/MT-CO1/SLC8A1/TPM2	0.953407864510249
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/444	87/9376	1.45635290462877	FOS/GADD45A/MYC/JUN/TGFB1/CDKN1A	0.953407864510249
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/444	70/9376	1.50836550836551	PAK3/PTPN11/JUN/TGFB1/CDKN1A	0.951801398962739
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/444	53/9376	1.59374468808431	SLC8A1/ATP2B1/AP2M1/CLTA	0.96641262757426
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/444	71/9376	1.48712092374064	CGA/FOS/SOCS3/LHCGR/NFKB1	0.918566359532402
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/444	54/9376	1.56423089756423	LDHA/BCAT1/SMS/ENOPH1	0.927047445045729
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/444	37/9376	1.71219868517166	GADD45A/MYC/CDKN1A	0.967730898890388
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/444	91/9376	1.39233739233739	FOS/NFKBIA/NFKB1/SYK/NFATC1/JUN	0.838479037427091
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/444	148/9376	1.28414901387874	FOS/GADD45A/FGF10/MYC/FGF7/JUN/DLL1/DLL3/CDKN1A	0.776829991060224
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/444	38/9376	1.66714082503556	AOX1/NNMT/CD38	0.918724181047455
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/444	56/9376	1.50836550836551	SCUBE2/SMURF2/BOC/CUL3	0.850677410145972
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/444	168/9376	1.25697125697126	CSH1/MCL1/AOX1/SOCS3/MYC/PTPN11/JAK1/IL2RG/CDKN1A/IL6	0.749306155785339
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/444	93/9376	1.36239465271723	ACTG1/MYL12B/ACTB/PTPRM/SMURF2/VCL	0.783036210598627
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/444	76/9376	1.38928402086297	UBC/DBI/SLC27A4/PLIN2/OLR1	0.759686948598679
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/444	77/9376	1.37124137124137	GADD45A/NFKB1/JAK1/TGFB1/CDKN1A	0.729266682874525
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/444	115/9376	1.28538973756365	NACA/EGR1/FOS/JUND/ATF4/CDKN1A/MMP16	0.686532492030586
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/444	59/9376	1.43166895709269	GSTM1/LAP3/SMS/HPGDS	0.741551883281883
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/444	24/9376	1.75975975975976	EXT1/XYLT1	0.830868751113061
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/444	156/9376	1.21829521829522	NFKBIA/SOCS3/MYC/YWHAQ/NFKB1/YWHAB/EIF3E/JAK1/CDKN1A	0.612976503303685
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/444	157/9376	1.21053537614047	ACTG1/MYC/YWHAQ/TP53BP2/YWHAB/BMP8B/SAV1/ACTB/TGFB1	0.593110708672771
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/444	178/9376	1.18635489422006	SFRP2/SERPINF1/CTNND2/MYC/TLE4/SFRP4/NFATC1/FOSL1/JUN/RSPO3	0.559637577075853
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/444	62/9376	1.36239465271723	TLE4/DTX4/DLL1/DLL3	0.638281526275627
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/444	140/9376	1.20669240669241	EGR1/GNG4/MAP1LC3B/RPS6/CALM1/SLC8A1/AGTR1/SPP1	0.549350272039898
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/444	44/9376	1.43980343980344	MGAT4C/MAN2A1/OSTC	0.651929091030546
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/444	160/9376	1.18783783783784	ITGAV/VCAN/JAM2/ITGB1/HLA-C/PTPRM/HLA-DQB1/HLA-B/HLA-DQB2	0.534286997035564
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/444	63/9376	1.34076934076934	PRDM6/PLOD2/EZH2/PRDM2	0.605046500536017
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/444	201/9376	1.15566312581238	GADD45A/PBX1/DDX5/MYC/CXCL8/NFKB1/NFKBIZ/KLF3/GRIA3/CDKN1A/IL6	0.497374488366146
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/444	83/9376	1.27211548898296	NFKBIA/NFKB1/IFI16/CCL4L2/IL6	0.555158644200386
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/444	143/9376	1.18137718137718	C1S/C2/C1R/C1QC/HLA-DQB1/SSB/FCGR2A/HLA-DQB2	0.48728384752587
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/444	65/9376	1.2995148995149	PDE8B/PBX1/AGTR1/ATF4	0.540231262322586
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/444	65/9376	1.2995148995149	CGA/TRPC4/GABBR1/SPP1	0.540231262322586
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/444	85/9376	1.24218335983042	NME2/TYMP/IMPDH2/GUK1/APRT	0.500063664135526
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/444	10/9376	2.11171171171171	PAPSS2	0.784183807271204
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/444	86/9376	1.22773936727425	ABL2/PAK3/MYC/JUN/CDKN1A	0.473022985039752
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/444	29/9376	1.45635290462877	RASSF4/SAV1	0.548739802687307
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/444	128/9376	1.15484234234234	PDE8B/NME2/IMPDH2/GUK1/PRPS2/PAPSS2/APRT	0.3932543839036
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/444	49/9376	1.29288472145615	NFKB1/JUN/ATF4	0.458275388943231
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/444	30/9376	1.40780780780781	NFKB1/IL6	0.498776566765189
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/444	70/9376	1.20669240669241	NFKBIA/SOCS3/NFKB1/PTPN11	0.386985581451686
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/444	254/9376	1.08079733276584	CALM1/SLC25A6/FGF10/LHCGR/SLC8A1/ATP2B1/FGF7/NFATC1/PHKG1/CD38/AGTR1/BDKRB1/P2RX4	0.291052688141333
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/444	31/9376	1.36239465271723	PRPS2/PGLS	0.450583973938848
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/444	31/9376	1.36239465271723	SPCS2/SEC61B	0.450583973938848
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/444	235/9376	1.07832087406555	ACTG1/RPS6/MT-CO3/MT-ND1/COX4I1/MT-CO1/MT-ATP8/BMP8B/NDUFS5/PRKG1/ACTB/MT-ND5	0.271092416148429
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/444	194/9376	1.08851119160398	ACTG1/MYL6/TUBB3/TPM4/MYL12B/TUBB4B/TPM2/ACTB/TUBB2A/MYH11	0.277736638208688
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/444	133/9376	1.11142721669037	HLA-C/PTPN11/SYK/NFATC1/HLA-B/KIR2DL3/TNFRSF10B	0.288544893323192
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/444	72/9376	1.17317317317317	NFKBIA/CXCL8/NFKB1/TRIM25	0.328862821338037
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/444	52/9376	1.21829521829522	CYP1B1/CGA/LHCGR	0.351922900311967
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/444	93/9376	1.13532887726436	EGR1/CGA/CALM1/JUN/ATF4	0.292408870945277
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/444	73/9376	1.15710230778724	PPIA/CHMP4B/RAN/NUP153	0.300424433136643
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/444	73/9376	1.15710230778724	GADD45A/FGF10/FGF7/CDKN1A	0.300424433136643
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/444	116/9376	1.09226467847158	GAPDH/ENO1/PRPS2/TPI1/PGLS/ENO2	0.222926521770059
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/444	117/9376	1.08292908292908	ACTG1/CDK2AP1/CHD4/ACTB/ZNHIT1/SRCAP	0.201242877095632
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/444	138/9376	1.07115811463638	MT-CO3/MT-ND1/COX4I1/MT-CO1/MT-ATP8/NDUFS5/MT-ND5	0.187749056432878
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/444	34/9376	1.24218335983042	RORA/CRY1	0.315403561488933
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/444	97/9376	1.08851119160398	FOS/GNG4/CALM1/PRKG1/GRIA3	0.195360263968407
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/444	139/9376	1.06345194114978	FOS/CALM1/HSP90AB1/JUN/GABBR1/HSPA8/ATF4	0.168031075496967
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/444	56/9376	1.13127413127413	MGAT4C/MAN2A1/OSTC	0.219668597050352
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/444	99/9376	1.06652106652107	FOS/JUN/DLL1/DLL3/CDKN1A	0.148345982283081
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/444	226/9376	1.02782428446145	CGA/FOS/CALM1/NFKBIA/LHCGR/NFKB1/ATP2B1/NFATC1/JUN/GABBR1/GRIA3	0.0943996628665958
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/444	142/9376	1.04098464661845	UBC/RPS27A/SOCS3/UBA52/SMURF2/UBE2E1/CUL3	0.1097168165428
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/444	144/9376	1.02652652652653	NFKBIA/CXCL8/NFKB1/C2/CXCL1/C1QC/IL6	0.0715181875652679
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/444	144/9376	1.02652652652653	SLC25A6/RORA/PSMA7/PSMD8/PSMB5/GRIA3/KCND3	0.0715181875652679
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/444	37/9376	1.14146579011444	GFPT2/UAP1	0.192222787095834
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/444	166/9376	1.01769239118637	CALM1/SLC25A6/SLC8A1/ATP2B1/NFATC1/AGTR1/PRKG1/ATF4	0.0512759279028704
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/444	59/9376	1.07375171781951	GADD45A/MYC/CDKN1A	0.126695988547983
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/444	38/9376	1.11142721669037	GFPT2/UAP1	0.153447180203377
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/444	82/9376	1.03010327400571	NME2/TYMP/IMPDH2/GSTM1	0.0610410632517427
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/444	212/9376	0.996090430052694	ACTG1/CALM1/FGF10/ITGB1/FGF7/PFN1/KITLG/ACTB/ENAH/APBB1IP	-0.0128368109078738
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/444	61/9376	1.03854674346478	SLC8A1/ATP2B1/MT2A	0.0673385789935496
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/444	170/9376	0.993746687864335	ACTG1/GADD45A/MYC/ACTB/GSTM1/TXNRD1/TGFB1/CDKN1A	-0.0183443297551025
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/444	17/9376	1.24218335983042	CA13	0.222821350957632
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/444	17/9376	1.24218335983042	MYH11	0.222821350957632
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/444	149/9376	0.992079327649798	GNG4/MT-ND1/NDUFS5/GRIA3/NAPEPLD/MT-ND5/GABRA2	-0.0217283970369393
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/444	106/9376	0.996090430052694	NFKBIA/NFKB1/HSP90AB1/ATF4/CDKN1A	-0.00902495030631517
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/444	150/9376	0.985465465465466	GADD45A/FGF10/MYC/FGF7/ABCB1/TGFB1/CDKN1A	-0.0400076275575904
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/444	63/9376	1.00557700557701	PTGDS/PTGES3/HPGDS	0.0099021458333634
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/444	18/9376	1.17317317317317	PRDX1	0.163956301528053
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/444	41/9376	1.03010327400571	GRIA3/GABRA2	0.0430676589182859
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/444	108/9376	0.977644310977644	EEF1A1/EIF4A3/KPNA2/RAN/NUP153	-0.0520966372222548
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/444	42/9376	1.00557700557701	CYP1B1/AOX1	0.00807596804332737
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/444	42/9376	1.00557700557701	MAP1LC3B/PRNP	0.00807596804332737
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/444	154/9376	0.95986895986896	CALM1/TPM4/SLC8A1/ATP2B1/AGTR1/TPM2/ATF4	-0.111951774971937
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/444	19/9376	1.11142721669037	HPSE2	0.108393323930091
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/444	89/9376	0.94908391537605	TUBB3/TUBB4B/PRKG1/TUBB2A	-0.107600687506282
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/444	20/9376	1.05585585585586	UAP1	0.0557495502365136
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/444	158/9376	0.935568479872277	GADD45A/MYC/YWHAQ/YWHAB/ESCO2/TGFB1/CDKN1A	-0.182100582656161
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/444	68/9376	0.931637519872814	ALDH1A3/AOX1/RDH12	-0.126138262720067
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/444	91/9376	0.928224928224928	PDE8B/GNG4/GABBR1/GABRA2	-0.153393212751612
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/444	21/9376	1.00557700557701	BCAT1	0.00570415865302812
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/444	138/9376	0.918135526831179	RPS6/CALM1/SOCS3/PHKG1/RHOQ/SH2B2	-0.215997538318192
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/444	70/9376	0.905019305019305	CYP1B1/GSTM1/HPGDS	-0.177830236059367
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/444	48/9376	0.87987987987988	BCAT1/AOX1	-0.186013675355998
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/444	23/9376	0.918135526831179	RPA2	-0.0876368357168467
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/444	323/9376	0.915293001980309	CD44/CYP1B1/TNXB/VIM/ZEB2/MCL1/MYC/NFKB1/ABCB1/MARCKS/EZH2/ITGA5/CDKN1A/MMP16	-0.345403757561177
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/444	73/9376	0.867826730840429	AOX1/GSTM1/HPGDS	-0.252752999127529
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/444	98/9376	0.861923147637433	CALM1/ATP2B1/AGTR1/ATF4	-0.30634408412813
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/444	122/9376	0.86545561955398	ACTG1/ITGAV/MYC/MED13/ACTB	-0.333490523128291
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/444	50/9376	0.844684684684685	LAP3/SMS	-0.245501610449957
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/444	99/9376	0.853216853216853	FOS/JUN/DGKI/SLC22A3	-0.32733525228811
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/444	75/9376	0.844684684684685	GADD45A/TNFRSF10B/CDKN1A	-0.301080659227827
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/444	193/9376	0.875320916771694	GNG4/NFKBIA/CXCL8/NFKB1/CXCL1/CXCL12/CCL4L2/FGR	-0.390195924182092
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/444	76/9376	0.833570412517781	ACTG1/CALM1/ACTB	-0.324786990204794
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/444	76/9376	0.833570412517781	CALM1/GADD45A/CDKN1A	-0.324786990204794
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/444	52/9376	0.812196812196812	LRP1/LIPG	-0.302765415823947
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/444	149/9376	0.850353709414112	CXCL8/PTPN11/SYK/AGTR1/KITLG/DGKI	-0.410517424934538
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/444	102/9376	0.828122239886946	RAB27B/ATP2B1/CD38/SLC12A2	-0.389124872636115
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/444	79/9376	0.801915839890524	CYP1B1/GSTM1/HPGDS	-0.394180053939797
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/444	27/9376	0.782115448782115	ELOVL5	-0.252771733353248
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/444	80/9376	0.791891891891892	RPS6/JAK1/IL6	-0.416762565832538
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/444	28/9376	0.754182754182754	ELOVL5	-0.290425521799865
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/444	28/9376	0.754182754182754	GCH1	-0.290425521799865
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/444	155/9376	0.81743679163034	PDE8B/PBX1/AGTR1/AHR/ATF4/CDKN1A	-0.510967012657999
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/444	107/9376	0.789424938957649	LDHA/CALM1/PHKG1/ATF4	-0.488410676685946
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/444	29/9376	0.728176452314383	CALM1	-0.326853184037709
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/444	298/9376	0.850353709414112	CSH1/CXCL8/BMP8B/CXCL1/CXCL12/IL32/IL2RG/TNFRSF10B/TGFB1/CCL4L2/IL6/EDA	-0.585304367717958
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/444	83/9376	0.763269293389775	EZH2/ASXL3/KDM2B	-0.482968090546886
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/444	133/9376	0.793876583350268	FOS/GNG4/CALM1/GRIA3/ATF4	-0.53376420084041
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/444	134/9376	0.787952131235713	CALM1/MYL6/AGTR1/PRKG1/MYH11	-0.551196047887112
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/444	59/9376	0.715834478546343	NME2/TYMP	-0.488159906185916
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/444	59/9376	0.715834478546343	CGA/PRKG1	-0.488159906185916
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/444	60/9376	0.703903903903904	PRKG1/GRIA3	-0.512975156629143
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/444	32/9376	0.65990990990991	LDHA	-0.429640603067292
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/444	33/9376	0.63991263991264	BCAT1	-0.46198134450761
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/444	33/9376	0.63991263991264	VAMP5	-0.46198134450761
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/444	89/9376	0.711812936532038	GNG4/GABBR1/GABRA2	-0.609024169642914
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/444	238/9376	0.798546445605269	GNG4/ABL2/CALM1/PAK3/FGF10/NFKB1/PTPN11/FGF7/KITLG	-0.701844017094754
NA	NA	hsa04519	Cadherin signaling	16/444	404/9376	0.836321469984836	ACTG1/LHFPL3/VIM/CTNND2/NFKBIA/YWHAQ/NFKB1/YWHAB/ARPC2/SAV1/ACTB/ENAH/GABRA2/CYFIP1/VCL/NCKAP1L	-0.749791533554625
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/444	63/9376	0.67038467038467	POLR2J2/RPA2	-0.58524220886929
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/444	63/9376	0.67038467038467	GADD45A/CDKN1A	-0.58524220886929
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/444	34/9376	0.621091679915209	POLR2J2	-0.493465090732137
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/444	168/9376	0.754182754182754	SLC25A6/PPIA/CHMP4B/HSP90AB1/JAK1/TNFRSF10B	-0.716782015467444
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/444	35/9376	0.603346203346203	TPI1	-0.524145326471745
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/444	169/9376	0.749720134335519	MAP1LC3B/UBC/RPS27A/UBA52/RAB7B/OPTN	-0.732003166932228
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/444	243/9376	0.782115448782115	HNRNPC/HNRNPA1/DDX5/EIF4A3/SF3B5/HSPA8/SRSF5/HNRNPM/RBMX	-0.767230063975079
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/444	65/9376	0.64975744975745	LIPG/DGKI	-0.631728088796471
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/444	195/9376	0.758050358050358	ACTG1/SLC25A6/NFKB1/SYK/ACTB/FCGR2A/TLR2	-0.761202247316127
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/444	36/9376	0.586586586586587	GBE1	-0.554070645220814
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/444	36/9376	0.586586586586587	GALNT13	-0.554070645220814
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/444	36/9376	0.586586586586587	RPA2	-0.554070645220814
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/444	67/9376	0.630361704988571	CALM1/ATF4	-0.676964056874321
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/444	37/9376	0.570732895057219	GFPT2	-0.58328532469872
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/444	37/9376	0.570732895057219	AOX1	-0.58328532469872
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/444	37/9376	0.570732895057219	IL6	-0.58328532469872
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/444	122/9376	0.692364495643184	FOS/CSH1/SOCS3/ATF4	-0.762525532026596
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/444	68/9376	0.621091679915209	MYC/NFKB1	-0.6991384329058
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/444	38/9376	0.555713608345187	IL2RG	-0.6118298206407
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/444	69/9376	0.612090351220786	CALM1/AGTR1	-0.721029505085492
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/444	98/9376	0.646442360728075	CALM1/DGKI/PIP4K2A	-0.784420337920631
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/444	39/9376	0.541464541464541	SARDH	-0.639741192366353
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/444	99/9376	0.63991263991264	CALM1/BDKRB1/TRPA1	-0.803016486859301
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/444	71/9376	0.594848369496257	LDHA/MYC	-0.763996453760604
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/444	41/9376	0.515051637002856	SARDH	-0.693797979800416
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/444	41/9376	0.515051637002856	RPA2	-0.693797979800416
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/444	73/9376	0.57855115389362	GADD45A/CDKN1A	-0.805930431391702
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/444	103/9376	0.615061663605353	PABPC1/EIF4A3/PABPC4	-0.875794903519234
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/444	43/9376	0.4910957469097	SLC27A4	-0.745697078090613
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/444	75/9376	0.563123123123123	GSTM1/CDKN1A	-0.846891227851203
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/444	75/9376	0.563123123123123	CGA/ATF4	-0.846891227851203
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/444	133/9376	0.635101266680214	GADD45A/TGFB1/CDKN1A/IL6	-0.944918747922212
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/444	44/9376	0.47993447993448	TAF4B	-0.770903115091987
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/444	45/9376	0.469269269269269	ABCB1	-0.795644680266763
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/444	78/9376	0.541464541464541	TPI1/PIP4K2A	-0.906626109122907
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/444	79/9376	0.534610559927016	AP2M1/CLTA	-0.9261075418125
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/444	47/9376	0.449300364193981	LDHA	-0.843818296127054
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/444	47/9376	0.449300364193981	SOCS3	-0.843818296127054
NA	NA	hsa04081	Hormone signaling	7/444	219/9376	0.674976346209223	CGA/GNG4/ITGAV/CSH1/LHCGR/AGTR1/PRKG1	-1.08508356244337
NA	NA	hsa03272	Virion - Hepatitis viruses	1/444	48/9376	0.43993993993994	CHMP4B	-0.867288761347341
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/444	49/9376	0.430961573818717	GALNT13	-0.890371832253171
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/444	83/9376	0.508846195593184	PRDX5/PRDX1	-1.00203145792052
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/444	115/9376	0.550881316098707	FOS/GNG4/ATF4	-1.08039823684089
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/444	115/9376	0.550881316098707	GNG4/APP/DUSP1	-1.08039823684089
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/444	144/9376	0.586586586586587	MYC/ID4/KLF4/JAK1	-1.11460420620587
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/444	86/9376	0.4910957469097	GABBR1/GABRA2	-1.05701272369969
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/444	54/9376	0.391057724391058	RPA2	-1.00050951342901
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/444	90/9376	0.469269269269269	NFKB1/ATF4	-1.12793459274212
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/444	57/9376	0.370475738896791	ELOVL5	-1.06284029184235
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/444	154/9376	0.548496548496548	BCAT1/NME2/RDH12/GCH1	-1.25953906593792
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/444	60/9376	0.351951951951952	HSPB1	-1.12271844625324
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/444	62/9376	0.340598663179308	HSPA8	-1.16139597683993
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/444	101/9376	0.418160734992418	CALM1/KITLG	-1.31071877307735
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/444	66/9376	0.31995631995632	CYP1B1	-1.23605188772752
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/444	138/9376	0.459067763415589	CALM1/YWHAQ/YWHAB	-1.4272373225714
NA	NA	hsa04082	Neuroactive ligand signaling	5/444	199/9376	0.53058083208837	GNG4/GABBR1/GRIA3/GABRA2/P2RX4	-1.49224371251183
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/444	69/9376	0.306045175610393	SYK	-1.28989290458748
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/444	116/9376	0.364088226157192	GNG4/GRIA3	-1.5364666332098
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/444	125/9376	0.337873873873874	NFKB1/S1PR3	-1.66151458016711
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/444	370/9376	0.570732895057219	CGA/CSH1/LHCGR/S1PR3/GABBR1/AGTR1/BDKRB1/GRIA3/GABRA2/P2RX4	-1.87830133086589
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/444	86/9376	0.24554787345485	ATF4	-1.56702462661283
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/444	90/9376	0.234634634634635	ABCB1	-1.62659145531992
NA	NA	hsa04382	Cornified envelope formation	4/444	217/9376	0.389255615062067	S100A16/S100A4/PCSK6/SLC27A4	-2.02940201064671
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/444	104/9376	0.203049203049203	DGKI	-1.82206654240775
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/444	191/9376	0.331682467808122	GNG4/CALM1/ATF4	-2.08047606423173
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/444	110/9376	0.191973791973792	HSP90AB1	-1.90054609776634
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/444	158/9376	0.267305279963508	RPS6/EIF4B	-2.07078981162095
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/444	122/9376	0.173091123910796	EEF2	-2.04963055872151
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	4/444	250/9376	0.337873873873874	LAPTM5/LITAF/AP2M1/CLTA	-2.36577404464344
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/444	183/9376	0.115394082607197	RAN	-2.69432214738265
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/444	449/9376	0.141094323722386	CALM1/SLC8A1/PRKG1	-4.1583270376691