category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	40/342	238/9376	4.60759742493489	RPL10/RPL18A/RPS20/RPL13A/RPS27/CFD/RPL12/RPL3/RPL15/RPLP0/RPS11/RPL37A/RPS29/RPL6/RPL23A/RPL31/RPL29/RPL27A/RPS4X/RPS13/RPS16/RPL7A/CXCL8/NFKBIA/PLCG2/RPS2/RPS25/ACE2/RPL4/RPS5/RPSA/RPS26/RPL10A/RPS17/RPL9/AGTR1/ACE/C9/C2/VWF	10.9683075127847
Genetic Information Processing	Translation	hsa03010	Ribosome	35/342	222/9376	4.3222169537959	RPL10/RPL18A/RPS20/RPL13A/RPS27/RPL12/RPL3/RPL15/RPLP0/RPS11/RPL37A/RPS29/RPL6/RPL23A/RPL31/RPL29/RPL27A/RPS4X/RPS13/RPS16/RPL7A/RPS2/MRPS24/RPS25/RPL4/RPS5/RPSA/RPS26/RPL10A/MRPL51/RPS17/RACK1/RPL9/MRPL41/MRPL40	9.74670163001525
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/342	89/9376	4.31250410670872	COL6A1/COL6A3/CD44/FN1/THBS2/SPP1/GP1BB/ITGAV/COL1A2/LAMC1/ITGB1/LAMB2/LAMC2/VWF	6.10903135285193
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/342	248/9376	2.76362950386719	ANXA2/MYL12B/ACTG1/GAPDH/CXCL8/NFKBIA/TUBB4B/PAK3/AHNAK2/TXN/RRAS/DYNLL1/RAB7B/ARPC2/RHOA/RAC1/TUBB3/TUBB2A/ARF1/S100A10/ARL8B/NAIP/CYTH4/TNFRSF10B/TCF7	5.47651180776686
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/342	203/9376	2.83605565638234	COL6A1/MYL12B/ACTG1/COL6A3/FN1/PAK3/THBS2/SPP1/ITGAV/COL1A2/RHOA/LAMC1/PDGFRB/ITGB1/RAC1/CAV1/LAMB2/LAMC2/RAP1B/VAV1/VWF	5.14560935326605
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/342	103/9376	3.72633849997161	CXCL8/FN1/CXCL1/COL1A2/COL3A1/RAB7B/LAMC1/PLCB1/PRDX1/IL1R1/LAMB2/LAMC2/SERPINB6/C9	5.41311068027115
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	20/342	196/9376	2.79746986513904	MAP1LC3B/GNG4/HLA-C/CALM1/CXCL8/NFKBIA/CLEC2B/UBC/PLCG2/HLA-B/CXCL1/NFATC1/CDKN1A/RAC1/PIK3R6/MAP1LC3B2/ICAM1/FGF2/GNG5/TCF7	4.94796890053054
NA	NA	hsa04518	Integrin signaling	17/342	154/9376	3.02635376319587	COL6A1/ACTG1/COL6A3/FN1/THBS2/SPP1/ITGAV/COL1A2/LIMS1/LAMC1/PDGFRB/ITGB1/RAC1/LAMB2/LAMC2/ICAM1/VWF	4.93312041918352
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/342	155/9376	3.00682890020751	ACTG1/HLA-C/TUBB4B/HLA-B/THBS2/ITGAV/CTSL/RAB7B/MSR1/SEC61B/ITGB1/HLA-DQB1/RAC1/HLA-DPA1/TUBB3/ATP6V1D/TUBB2A	4.90168990238478
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/342	116/9376	3.30873159911272	MYL12B/ACTG1/JAM2/MMP2/PLCG2/RHOA/GNAI1/ITGB1/RAC1/CXCR4/RAP1B/VAV1/ICAM1/RASSF5	4.86805634687018
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/342	93/9376	3.53744576495001	NFKBIA/FN1/GADD45B/ITGAV/GADD45A/CDKN1A/LAMC1/ITGB1/LAMB2/LAMC2/GADD45G/CDKN2B	4.784677997254
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/342	204/9376	2.55337690631808	DDX5/ACTG1/CD44/FN1/MMP2/DCN/PLCG2/RRAS/ITGAV/COL1A2/CTSL/RHOA/CDKN1A/ITGB1/RAC1/CAV1/VAV1/HSPB2/FGF2	4.36433976441363
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/342	193/9376	2.55685846741205	GNG4/CXCL8/NFKBIA/PLCG2/CXCL14/CXCL1/DOCK2/RHOA/GNAI1/CCL4L2/PLCB1/RAC1/CXCR4/RAP1B/PIK3R6/CXCL16/VAV1/GNG5	4.25200869068123
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/342	101/9376	3.25725204099357	CXCL8/FN1/MMP2/PLCG2/NFATC1/COL1A2/EGR1/COL3A1/AGTR1/PLCB1/RAC1/ICAM1	4.4375415268713
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/342	200/9376	2.46736842105263	ACTG1/GAPDH/CXCL8/NFKBIA/TUBB4B/PAK3/ARPC2/RHOA/ITGB1/RAC1/TUBB3/IL1R1/TUBB2A/ARF1/NAIP/CYTH4/TNFRSF10B/SEC24A	4.08118340432213
Organismal Systems	Immune system	hsa04611	Platelet activation	13/342	126/9376	2.82855286364058	MYL12B/ACTG1/PLCG2/GP1BB/COL1A2/COL3A1/RHOA/GNAI1/ITGB1/PLCB1/RAP1B/PIK3R6/VWF	4.02050470471922
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/342	233/9376	2.23557463042442	FBLN1/VIM/COL6A1/ACTG1/COL6A3/FN1/DCN/THBS2/PDLIM2/ITGAV/COL1A2/PDLIM1/COL3A1/MYPN/ITGB1/SPTBN1/AMPD3/SYNE1/FMNL3	3.71587615615427
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/342	56/9376	3.91645781119465	EEF1A1/EEF1G/CXCL8/NFKBIA/CXCL1/VCP/ARF1/NAIP	4.25892903703556
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/342	253/9376	2.16720985599704	MAP1LC3B/MYL12B/ACTG1/CD44/SEPTIN11/CXCL8/NFKBIA/UBC/PLCG2/ARPC2/RHOA/ITGB1/PLCB1/RAC1/IL1R1/ARF1/MAP1LC3B2/NAIP/CYTH4/CAPNS1	3.66183707432369
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/342	70/9376	3.52481203007519	ABL2/ACTG1/HLA-C/HLA-B/HLA-DQB1/RAC1/HLA-DPA1/CAV1/ICAM1	4.12529675203927
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/342	275/9376	2.09352472089314	COX4I1/SLC25A6/TUBB4B/PSMB5/EGR1/PRNP/MT-ATP8/NDUFS5/LAMC1/NDUFV3/PSMA7/RAC1/ATP5PO/CAV1/TUBB3/PSMB1/TUBB2A/PSMD8/NDUFA12/C9/ATP5F1B	3.58103893777681
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/342	205/9376	2.27345599771787	VIM/HLA-C/CD44/NFKBIA/PLCG2/HLA-B/GADD45B/RUNX3/GADD45A/CDKN1A/ENTPD1/HLA-DQB1/RAC1/HLA-DPA1/PSMD8/ICAM1/GADD45G	3.58683315163362
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/342	205/9376	2.27345599771787	COX4I1/GAPDH/SLC25A6/MMP2/COL1A2/MT-ATP8/COL3A1/NDUFS5/AGTR1/NDUFV3/PLCB1/RAC1/ATP5PO/ACE/GFPT2/NDUFA12/ATP5F1B	3.58683315163362
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/342	105/9376	2.87206906154275	MAP1LC3B/UBC/RABGEF1/RRAS/RAB7B/BNIP3L/OPTN/SMURF2/VCP/MAP1LC3B2/TOMM7	3.75328785184096
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/342	227/9376	2.1738928819847	GNG4/HLA-C/CALM1/CXCL8/NFKBIA/HLA-B/NFATC1/ITGAV/RHOA/GNAI1/CDKN1A/CCL4L2/PLCB1/RAC1/IL1R1/CXCR4/IL10RA/GNG5	3.48347928395984
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/342	157/9376	2.44466793310239	HLA-C/CALM1/CXCL8/SLC25A6/HLA-B/NFATC1/RRAS/GADD45B/GADD45A/CDKN1A/ETS1/GADD45G/RASSF5/CDKN2B	3.55168629788262
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/342	142/9376	2.50984268182193	ACTG1/CALM1/MMP2/TXN/ITGAV/CTSL/RHOA/RAC1/CAV1/IL1R1/GSTM1/ICAM1/NQO1	3.52727713797141
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/342	232/9376	2.12704174228675	MYL12B/ACTG1/GSN/TMSB4X/FN1/PAK3/RRAS/ITGAV/ARPC2/RHOA/PDGFRB/ITGB1/RAC1/BDKRB1/CXCR4/VAV1/FGF2/C9	3.38200724169273
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/342	51/9376	3.76287123036349	ACTG1/PLCG2/KDELR2/SEC61B/KCNQ1/ATP6V1D/ARF1	3.84928404934216
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/342	268/9376	1.94361525704809	COX4I1/CALM1/SLC25A6/TUBB4B/PSMB5/UBC/TXN/MT-ATP8/NDUFS5/GNAI1/NDUFV3/PSMA7/ATP5PO/TUBB3/PSMB1/TUBB2A/PSMD8/NDUFA12/ATP5F1B	3.04936554182351
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/342	250/9376	1.97389473684211	HLA-C/HLA-B/AP2M1/ARPC2/RHOA/IQSEC1/ARAP2/CAV1/ASAP1/VPS28/SMURF2/CXCR4/ARF1/FOLR2/DAB2/CYTH4/CHMP2B/BIN1	3.03668985835469
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/342	105/9376	2.61097187412977	CXCL8/NFKBIA/PLCG2/CXCL1/GADD45B/GADD45A/CCL4L2/IL1R1/ICAM1/GADD45G	3.22981736573647
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/342	140/9376	2.34987468671679	MAP1LC3B/GNG4/CALM1/SPP1/RRAS/EGR1/GNAI1/AGTR1/PLCB1/PIK3R6/MAP1LC3B2/GNG5	3.13093576210156
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	23/342	362/9376	1.74185002100094	COL6A1/GNG4/COL6A3/CSH1/FN1/THBS2/SPP1/YWHAB/ITGAV/COL1A2/CDKN1A/LAMC1/PDGFRB/ITGB1/RAC1/DDIT4/LAMB2/LAMC2/PIK3R6/PIK3AP1/FGF2/GNG5/VWF	2.80072372180007
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/342	78/9376	2.81181586444744	ACTG1/SEPTIN11/FN1/ARPC2/RHOA/ITGB1/RAC1/CAV1	3.12626102707905
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/342	112/9376	2.44778613199666	NFKBIA/GNAI1/LAMC1/ITGB1/HLA-DQB1/HLA-DPA1/LAMB2/LAMC2/PIK3R6/IL10RA	2.9989746764767
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/342	224/9376	1.95822890559733	HLA-C/NFKBIA/SLC25A6/HLA-B/NFATC1/EGR1/MSX1/CDKN1A/RAN/HLA-DQB1/HLA-DPA1/IL1R1/ETS1/ICAM1/MSX2/CDKN2B	2.82419005284465
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/342	308/9376	1.78020809599757	COX4I1/TGM2/SLC25A6/TUBB4B/PSMB5/MT-ATP8/GRIA3/NDUFS5/AP2M1/NDUFV3/PSMA7/PLCB1/ATP5PO/TUBB3/PSMB1/TUBB2A/PSMD8/NDUFA12/ATP5F1B/POLR2J2	2.70887336607745
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/342	37/9376	3.70475738896792	GADD45B/GADD45A/CDKN1A/GADD45G/TCF7	3.20728562919767
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/342	103/9376	2.39550332141032	COL6A1/COL6A3/COL15A1/ACE2/COL1A2/COL3A1/COL18A1/KCNQ1/COL21A1	2.77075423083331
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/342	54/9376	3.0461338531514	CGA/HLA-C/HLA-B/HLA-DQB1/HLA-DPA1/TG	2.93383050243635
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/342	71/9376	2.70290750350054	JAM2/CXCL8/NFKBIA/PLCG2/CXCL1/RAC1/ATP6V1D	2.80233914170394
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/342	88/9376	2.4922913343966	CFD/PROCR/CD59/BDKRB1/SERPINE2/C9/C2/VWF	2.73648138325044
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/342	368/9376	1.63895245359776	MAP1LC3B/ACTG1/COX4I1/TUBB4B/PSMB5/MT-ATP8/NDUFS5/NDUFV3/PSMA7/RAC1/ATP5PO/TUBB3/OPTN/PSMB1/TUBB2A/VCP/PSMD8/MAP1LC3B2/NDUFA12/SRSF3/CHMP2B/ATP5F1B	2.43297087971517
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/342	41/9376	3.34331764370275	CXCL8/MMP2/CDKN1A/TYMP/DAPK1	2.92566487605703
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/342	110/9376	2.24306220095694	THSD4/FMOD/DCN/RHOA/NBL1/SMURF2/BMP8A/BMP8B/CDKN2B	2.55153601850664
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/342	227/9376	1.81157740165391	ABL2/CYP1B1/COX4I1/NFKBIA/SLC25A6/MT-ATP8/PTPRJ/NDUFS5/NDUFV3/RAC1/ATP5PO/GSTM1/NDUFA12/NQO1/ATP5F1B	2.40832286265471
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/342	93/9376	2.35829717663334	MYL12B/ACTG1/PTPRJ/RHOA/RAC1/SMURF2/RAP1B/TCF7	2.56124276803915
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/342	149/9376	2.02394128497979	CXCL8/PLCG2/RRAS/RHOA/DGKI/AGTR1/PDGFRB/PLCB1/PIK3R6/ARF1/CYTH4	2.45130062517131
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/342	76/9376	2.52508464142813	CALM1/PLCG2/GADD45B/GADD45A/CDKN1A/PDGFRB/GADD45G	2.59727489357181
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/342	45/9376	3.0461338531514	HLA-C/HLA-B/HLA-DQB1/HLA-DPA1/KIR2DL3	2.67691666316959
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/342	78/9376	2.46033888139151	CALM1/CXCL8/RHOA/GNAI1/ITGB1/IRF8/C2	2.51979277850889
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/342	133/9376	2.06129358483929	HLA-C/PLCG2/HLA-B/NFATC1/RAC1/KIR2DL3/VAV1/ICAM1/TNFRSF10B/NCR1	2.39835535443413
NA	NA	hsa04517	IgSF CAM signaling	18/342	299/9376	1.65041365956698	MYL12B/ACTG1/JAM2/TUBB4B/PAK3/PLCG2/DYNLL1/ARPC2/RHOA/ITGB1/EPB41L3/RAC1/TUBB3/SPTBN1/TUBB2A/RAP1B/VAV1/ICAM1	2.22388706083567
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/342	98/9376	2.23797589211123	GSN/PLCG2/ARPC2/RAC1/ASAP1/VAV1/MARCKS/BIN1	2.39693738611791
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	26/342	480/9376	1.48499025341131	MAP1LC3B/COX4I1/CALM1/SLC25A6/TUBB4B/PSMB5/UBC/PRNP/MT-ATP8/GRIA3/NDUFS5/NDUFV3/PSMA7/PLCB1/RAC1/ATP5PO/TUBB3/OPTN/PSMB1/TUBB2A/VCP/PSMD8/MAP1LC3B2/NDUFA12/CHMP2B/ATP5F1B	2.1223396640012
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/342	138/9376	1.98660903466395	ACTG1/CXCL8/NFKBIA/FN1/NFATC1/ARPC2/RHOA/ITGB1/RAC1/VAV1	2.27171737899843
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	19/342	333/9376	1.56423089756423	COL6A1/HLA-C/COL6A3/FN1/HLA-B/THBS2/SPP1/ITGAV/COL1A2/CDKN1A/LAMC1/PDGFRB/PKM/ITGB1/ATP6V1D/LAMB2/LAMC2/TCF7/VWF	2.03977077030573
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/342	87/9376	2.20582106607515	GADD45B/GADD45A/RHOA/CDKN1A/RAC1/GADD45G/TCF7	2.19845033947978
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/342	70/9376	2.34987468671679	PAK3/CDKN1A/RAC1/RAP1B/ETS1/ELOC	2.20556365956755
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/342	169/9376	1.78442160628395	MAP1LC3B/UBC/RRAS/CTSL/RAB7B/OPTN/DDIT4/MAP1LC3B2/IGBP1/DAPK1/SNAP29	2.00213093650447
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/342	149/9376	1.8399466227089	GNG4/MGLL/GRIA3/NDUFS5/GNAI1/NDUFV3/PLCB1/NDUFA12/GNG5/GABRE	2.01082006513439
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/342	212/9376	1.6811210415977	ACTG1/CALM1/RRAS/RHOA/GNAI1/PDGFRB/ITGB1/PLCB1/RAC1/RAP1B/VAV1/FGF2/RASSF5	1.95167875796258
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/342	214/9376	1.66540962999399	GNG4/HLA-C/CALM1/NFKBIA/PAK3/PLCG2/HLA-B/NFATC1/GNAI1/RAC1/CXCR4/ELOC/GNG5	1.91584104291133
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/342	23/9376	3.57589626239512	ACE2/AGTR1/ACE	2.40644238294672
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/342	73/9376	2.25330449411199	GADD45B/GADD45A/CDKN1A/PDGFRB/FGF2/GADD45G	2.09153513558154
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/342	73/9376	2.25330449411199	PLCG2/GADD45B/GADD45A/CDKN1A/GADD45G/RASSF5	2.09153513558154
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/342	39/9376	2.81181586444744	HLA-C/HLA-B/HLA-DQB1/HLA-DPA1	2.2059787788892
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/342	93/9376	2.06351002955417	NFKBIA/NFATC1/RUNX3/HLA-DQB1/HLA-DPA1/DLL1/DLL3	2.00538396073543
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/342	238/9376	1.61265909872721	ABL2/GNG4/CALM1/PAK3/PLCG2/RRAS/RHOA/PDGFRB/RAC1/RAP1B/ETS1/FGF2/RASSF5/GNG5	1.86268937573234
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/342	75/9376	2.19321637426901	GADD45B/GADD45A/CDKN1A/TP53I3/TNFRSF10B/GADD45G	2.01856929171526
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/342	95/9376	2.02006771314251	CXCL8/CXCL1/CTSL/HLA-DQB1/HLA-DPA1/ATP6V1D/ICAM1	1.94424981389559
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/342	76/9376	2.16435826408126	ACTG1/CALM1/GNAI1/PLCB1/KCNQ1/KCNJ15	1.98294468665634
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/342	115/9376	1.9071446732774	NACA/EGR1/RHOA/GNAI1/CDKN1A/PLCB1/MMP25/NACA2	1.90438688060875
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/342	77/9376	2.13624971519708	NFKBIA/GADD45B/GADD45A/CDKN1A/RUNX1/GADD45G	1.9478686783871
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/342	59/9376	2.32332243036971	GADD45B/GADD45A/CDKN1A/GADD45G/TCF7	1.98386575160719
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/342	42/9376	2.61097187412977	MAP1LC3B/FTL/PRNP/MAP1LC3B2	2.03581051512904
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/342	12/9376	4.56920077972709	VKORC1/NQO1	2.40707458718893
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/342	226/9376	1.5769808000828	CGA/CALM1/NFKBIA/NFATC1/RRAS/LHCGR/GRIA3/RHOA/GNAI1/RAC1/RAP1B/PDE10A/VAV1	1.7082981959104
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/342	43/9376	2.55025159798722	ALDH9A1/ACAA2/ACADVL/CPT1C	1.98236869429553
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/342	100/9376	1.91906432748538	CXCL8/CXCL14/CXCL1/CCL4L2/CXCR4/IL10RA/TNFRSF10B	1.79772884930228
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/342	100/9376	1.91906432748538	CD44/GP1BB/CD59/HLA-DQB1/HLA-DPA1/IL1R1/CD9	1.79772884930228
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/342	44/9376	2.4922913343966	HLA-C/HLA-B/HLA-DQB1/HLA-DPA1	1.93041746626867
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/342	82/9376	2.00599058622165	HLA-C/HLA-B/CTSL/HLA-DQB1/HLA-DPA1/KIR2DL3	1.78015638761295
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/342	63/9376	2.17580989510814	GADD45B/GADD45A/CDKN1A/GADD45G/TCF7	1.82188614045533
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/342	187/9376	1.61265909872721	MAP1LC3B/CXCL8/NFKBIA/CXCL1/TXN/RHOA/PLCB1/IFI16/PSTPIP1/MAP1LC3B2/NAIP	1.64650939564188
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/342	46/9376	2.38393084159675	PSMB5/PSMA7/PSMB1/PSMD8	1.83067449082817
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/342	105/9376	1.82768031189084	CALM1/NFKBIA/PLCG2/NFATC1/RRAS/RHOA/LSP1	1.65940590742298
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/342	85/9376	1.93519091847265	GUK1/NME2/APRT/ENTPD1/AMPD3/TYMP	1.68514455612562
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/342	14/9376	3.91645781119465	CHST2/B3GNT7	2.12468252511246
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/342	170/9376	1.61265909872721	ACTG1/PLCG2/GADD45B/GADD45A/CDKN1A/GSTM1/TXNRD1/GADD45G/NQO1/TCF7	1.56843494979099
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/342	128/9376	1.71345029239766	PDE8B/GUK1/NME2/PAPSS2/APRT/ENTPD1/PDE10A/AMPD3	1.58126057398688
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/342	216/9376	1.5230669265757	CALM1/CXCL8/NFKBIA/CXCL1/NFATC1/RHOA/PLCB1/RAC1/RAP1B/VAV1/ICAM1/TNFRSF10B	1.51319552192468
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/342	130/9376	1.68708951866847	GNG4/NFKBIA/MMP2/COL1A2/COL3A1/GNAI1/PLCB1/GNG5	1.53485270270834
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/342	89/9376	1.84821604573231	TUBB4B/GNAI1/PDGFRB/PLCB1/TUBB3/TUBB2A	1.56430852625246
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/342	69/9376	1.98660903466395	CALM1/GNAI1/AGTR1/PLCB1/ACE	1.60038113971159
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/342	50/9376	2.19321637426901	CXCL8/THBS2/HBB/ICAM1	1.64594435654512
Human Diseases	Immune disease	hsa05310	Asthma	3/342	32/9376	2.57017543859649	PRG2/HLA-DQB1/HLA-DPA1	1.73107307737165
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/342	154/9376	1.60218728639781	ACTG1/CALM1/NFATC1/RHOA/GNAI1/CDKN1A/PLCB1/PIK3R6/CACNB3	1.46601371026971
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/342	155/9376	1.5918505942275	PDE8B/GNAI1/CDKN1A/AGTR1/PLCB1/CYP11A1/RAP1B/TCF7/CDKN2B	1.44559811807843
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/342	91/9376	1.80759591285907	NFKBIA/PLCG2/NFATC1/RAC1/VAV1/PIK3AP1	1.50619951217033
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/342	91/9376	1.80759591285907	GNG4/PDE8B/GNAI1/PDE10A/GNG5/GABRE	1.50619951217033
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/342	178/9376	1.54018003811026	SFRP2/SFRP4/NFATC1/CTNND2/RHOA/PLCB1/RAC1/RSPO3/NOTUM/TCF7	1.41566494407567
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/342	52/9376	2.10886189833558	CYP1B1/CGA/LHCGR/CYP11A1	1.56004328483999
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/342	52/9376	2.10886189833558	LRPAP1/ABCG8/SOAT1/LIPG	1.56004328483999
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/342	17/9376	3.22531819745442	PAPSS2/TXNRD1	1.78673647999973
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/342	73/9376	1.87775374509333	PPIA/RAN/MAP1B/CXCR4/FEZ1	1.46480987411741
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/342	205/9376	1.47105976322921	HLA-C/GSN/NFKBIA/HLA-B/YWHAB/RHOA/CDKN1A/PKM/HDAC9/RAC1/CDKN2B	1.32679321325521
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/342	160/9376	1.54210526315789	HLA-C/JAM2/HLA-B/ITGAV/ITGB1/HLA-DQB1/HLA-DPA1/ICAM1/SPN	1.34564663637749
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/342	138/9376	1.58928722773116	COX4I1/MT-ATP8/NDUFS5/NDUFV3/ATP5PO/ATP6V1D/NDUFA12/ATP5F1B	1.35686375192647
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/342	184/9376	1.48995677599797	MYL12B/PAK3/PLCG2/RHOD/RRAS/RHOA/GNAI1/ITGB1/RAC1/CXCR4	1.3059312670442
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/342	97/9376	1.69578585639356	GNG4/CALM1/GRIA3/GNAI1/PLCB1/GNG5	1.34019972428854
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/342	120/9376	1.59922027290448	CALM1/NFKBIA/PLCG2/RHOA/RAC1/RAP1B/BEX3	1.28535797424645
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/342	77/9376	1.78020809599757	GADD45B/GADD45A/CDKN1A/RAC1/GADD45G	1.33750784927951
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/342	235/9376	1.39992534527809	ACTG1/COX4I1/MT-ATP8/MGLL/NDUFS5/NDUFV3/ATP5PO/CPT1C/BMP8A/NDUFA12/BMP8B/ATP5F1B	1.20802147055239
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/342	37/9376	2.22285443338075	PLCB1/HBB/ICAM1	1.45005369678621
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/342	99/9376	1.6615275562644	CFD/HLA-DQB1/HLA-DPA1/KRT34/ICAM1/C2	1.2874204600294
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/342	78/9376	1.75738491527965	EEF1A1/NFKBIA/ITGB1/HLA-DQB1/HLA-DPA1	1.30685628136856
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/342	144/9376	1.5230669265757	CXCL8/NFKBIA/CXCL1/ALDH9A1/ACADVL/CPT1C/C2/TCF7	1.23069165790176
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/342	38/9376	2.16435826408126	NNMT/NMRK1/AOX1	1.39929776857373
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/342	59/9376	1.85865794429577	CGA/MGLL/GNAI1/ABHD5	1.28726155390406
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/342	102/9376	1.61265909872721	RAB27B/RHOA/PLCB1/RAC1/KCNQ1/RAP1B	1.21044225489197
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/342	170/9376	1.45139318885449	MYL12B/ACTG1/JAM2/ARPC2/RHOA/ITGB1/RAB13/RAC1/RUNX1	1.15558694054786
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/342	148/9376	1.48190295558717	GADD45B/GADD45A/CDKN1A/DLL1/DLL3/FGF2/GADD45G/TCF7	1.14972851537672
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	18/342	388/9376	1.27183939229517	COX4I1/CALM1/GAPDH/SLC25A6/TUBB4B/PSMB5/MT-ATP8/NDUFS5/NDUFV3/PSMA7/PLCB1/ATP5PO/TUBB3/PSMB1/TUBB2A/PSMD8/NDUFA12/ATP5F1B	1.06403366708645
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/342	173/9376	1.42622452083967	ACTG1/CXCL8/NFKBIA/SLC25A6/SOCS3/HLA-DQB1/HLA-DPA1/ICAM1/TNFRSF10B	1.100919134085
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/342	150/9376	1.46214424951267	GADD45B/GADD45A/CDKN1A/ABCB1/FGF2/GADD45G/TCF7/CDKN2B	1.11013323825145
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/342	174/9376	1.41802782819117	CRYAB/P4HB/UBXN1/SEC61B/SSR3/HERPUD1/VCP/SEC24A/EDEM2	1.08292243617407
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/342	42/9376	1.95822890559733	CYP1B1/ALDH9A1/AOX1	1.21092895117701
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/342	86/9376	1.59390724874201	ACTG1/ITGAV/ITGB1/CACNB3/TCF7	1.0765114233761
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/342	109/9376	1.5090938355062	NFKBIA/NFATC1/HLA-DQB1/HLA-DPA1/IL1R1/RUNX1	1.0401600124117
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/342	65/9376	1.68708951866847	ALDH9A1/MGLL/DGKI/LIPG	1.08150986865249
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/342	65/9376	1.68708951866847	PDE8B/AGTR1/PLCB1/CYP11A1	1.08150986865249
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/342	110/9376	1.49537480063796	TIMP1/LDHA/GAPDH/PLCG2/CDKN1A/ELOC	1.01681689421114
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/342	45/9376	1.82768031189084	ABCB1/ABCG8/ABCA8	1.08283786775021
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/342	67/9376	1.63672863751418	LDHA/GAPDH/ALDH9A1/PKM	1.01765112595614
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/342	137/9376	1.40077688137619	ACTG1/NFKBIA/GADD45B/CTSL/GADD45A/TNFRSF10B/GADD45G	0.919409759905539
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/342	115/9376	1.43035850495805	GNG4/GNAI1/PLCB1/KCNQ1/PIK3R6/GNG5	0.903460181097137
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/342	47/9376	1.74990668159761	LDHA/ALDH9A1/PKM	1.00276058189627
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/342	93/9376	1.47393573539584	CGA/CALM1/MMP2/EGR1/PLCB1	0.893666346128006
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/342	48/9376	1.71345029239766	ALDH9A1/ACAA2/AOX1	0.964159130591229
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/342	166/9376	1.32121468329458	CALM1/SLC25A6/NFATC1/RHOA/GNAI1/AGTR1/PLCB1/PIK3R6	0.812415623079115
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/342	144/9376	1.33268356075374	SLC25A6/PSMB5/GRIA3/PSMA7/PLCB1/PSMB1/PSMD8	0.782750470615777
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/342	50/9376	1.64491228070175	HLA-DQB1/HLA-DPA1/CXCR4	0.889603722994491
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/342	194/9376	1.27183939229517	MYL12B/ACTG1/TUBB4B/DYNLL1/TUBB3/KIF1B/TUBB2A/MYO16/KIF17	0.74439467800529
NA	NA	hsa04081	Hormone signaling	10/342	219/9376	1.25183583006222	CGA/GNG4/CSH1/LHCGR/ITGAV/RHOA/GNAI1/AGTR1/PLCB1/GNG5	0.733705235470493
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/342	99/9376	1.384606296887	CALM1/PLCG2/PLCB1/BDKRB1/IL1R1	0.74849492055107
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/342	99/9376	1.384606296887	ACTG1/ITGAV/ITGB1/ACE/CACNB3	0.74849492055107
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/342	30/9376	1.82768031189084	GGH/FOLR2	0.883423630349358
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/342	300/9376	1.18799220272904	NFATC1/RRAS/GADD45B/GADD45A/PDGFRB/PTPN5/RAC1/IL1R1/RAP1B/DUSP16/FGF2/GADD45G/CACNB3	0.643890278987439
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/342	125/9376	1.3159298245614	RHOA/GNAI1/PLCB1/RAC1/SGMS2/SPTSSB	0.691846806251661
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/342	10/9376	2.74152046783626	PAPSS2	1.07203793721536
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/342	103/9376	1.33083517856129	CXCL8/NFKBIA/GNAI1/PLCB1/ACE	0.656869071283034
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/342	254/9376	1.18727264355113	CALM1/SLC25A6/PLCG2/NFATC1/LHCGR/AGTR1/PDGFRB/PLCB1/BDKRB1/CXCR4/FGF2	0.588714609719985
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/342	154/9376	1.2461456671983	CALM1/GNAI1/AGTR1/PLCB1/KCNQ1/PIK3R6/CACNB3	0.599237033041258
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/342	180/9376	1.21845354126056	PILRA/HLA-C/NFKBIA/SOCS3/HLA-B/HLA-DQB1/HLA-DPA1/SRSF3	0.575777259968871
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/342	56/9376	1.468671679198	SCUBE2/SMURF2/CUL3	0.684405382348024
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/342	33/9376	1.6615275562644	VAMP5/SNAP29	0.740662545294914
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/342	106/9376	1.29317003199823	NFKBIA/CDKN1A/PDGFRB/FOLR2/TCF7	0.590597070038756
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/342	57/9376	1.4429055093875	ACAA2/ACADVL/CPT1C	0.652563085360477
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/342	157/9376	1.2223339665512	COX4I1/CXCL8/SOCS3/NDUFS5/NDUFV3/RAC1/NDUFA12	0.546603468146484
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/342	107/9376	1.28108433076461	LDHA/CALM1/PKM/PLCB1/CPT1C	0.568945585605672
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/342	133/9376	1.23677615090357	GNG4/CALM1/GRIA3/GNAI1/PLCB1/GNG5	0.53507658713294
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/342	59/9376	1.39399345822183	NME2/ENTPD1/TYMP	0.590657356200927
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/342	109/9376	1.25757819625516	CXCL8/NFKBIA/SPP1/CCL4L2/RAC1	0.526273392305678
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/342	60/9376	1.37076023391813	GRIA3/GNAI1/PLCB1	0.560547836715782
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/342	86/9376	1.27512579899361	ABL2/PAK3/PLCG2/CDKN1A	0.498690773869901
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/342	62/9376	1.32654216185625	DLL1/DTX4/DLL3	0.501909758588952
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/342	298/9376	1.10396797362534	CSH1/CXCL8/CXCL14/CXCL1/CCL4L2/IL1R1/CXCR4/BMP8A/CXCL16/BMP8B/IL10RA/TNFRSF10B	0.354871621109539
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/342	89/9376	1.23214403048821	GNG4/GNAI1/GNG5/GABRE	0.4281278196026
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/342	142/9376	1.15838893007166	UBC/SOCS3/SMURF2/UBE2E1/ELOC/CUL3	0.370026399886477
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/342	142/9376	1.15838893007166	NFKBIA/PLCG2/SOCS3/NFATC1/RAC1/IL1R1	0.370026399886477
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/342	116/9376	1.18168985682597	GNG4/GRIA3/GNAI1/PLCB1/GNG5	0.383100599924014
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/342	65/9376	1.26531713900135	CGA/SPP1/PLCB1	0.41762113430093
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/342	66/9376	1.2461456671983	NFATC1/HLA-DQB1/HLA-DPA1	0.390434306325886
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/342	41/9376	1.3373270574811	GRIA3/GABRE	0.421157552612751
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/342	67/9376	1.22754647813564	CALM1/PLCB1/RAP1B	0.363676008960612
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/342	16/9376	1.71345029239766	GBGT1	0.555705167564051
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/342	94/9376	1.16660445439841	CXCL8/NFKBIA/CXCL1/MAPK6	0.315855469367121
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/342	201/9376	1.09115242500946	DDX5/CXCL8/GADD45B/GADD45A/GRIA3/CDKN1A/RUNX1/GADD45G	0.254168582828923
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/342	122/9376	1.12357396222797	NFKBIA/PAK3/NFATC1/RHOA/VAV1	0.267301125756895
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/342	122/9376	1.12357396222797	ACTG1/PLCG2/ITGAV/PLCB1/MED13	0.267301125756895
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/342	122/9376	1.12357396222797	CSH1/PLCG2/SOCS3/GNAI1/PLCB1	0.267301125756895
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/342	69/9376	1.19196542079837	PLCG2/RAC1/VAV1	0.311387619744588
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/342	69/9376	1.19196542079837	CALM1/ARC/GRIA3	0.311387619744588
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/342	17/9376	1.61265909872721	HSD3B7	0.491911836586724
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/342	70/9376	1.1749373433584	NFKBIA/SOCS3/CPT1C	0.285830567095832
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/342	98/9376	1.11898794605562	CALM1/PLCG2/DGKI/PLCB1	0.230381430054907
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/342	98/9376	1.11898794605562	CALM1/AGTR1/PLCB1/CYP11A1	0.230381430054907
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/342	71/9376	1.15838893007166	CGA/SOCS3/LHCGR	0.260648037218702
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/342	71/9376	1.15838893007166	LDHA/PDGFRB/PKM	0.260648037218702
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/342	18/9376	1.5230669265757	PRDX1	0.432175995227266
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/342	99/9376	1.1076850375096	MMP2/CDKN1A/DLL1/DLL3	0.209569381072739
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/342	99/9376	1.1076850375096	DGKI/PDGFRB/RAC1/CHKB	0.209569381072739
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/342	46/9376	1.19196542079837	FTL/BLVRB	0.253933353036058
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/342	101/9376	1.08575068033119	CALM1/GNAI1/PLCB1/TCF7	0.16857763245598
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/342	157/9376	1.04771482847245	NFATC1/ITGAV/RAB7B/RAC1/CPT1C/DUSP16	0.117305921041321
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/342	157/9376	1.04771482847245	ACTG1/YWHAB/BMP8A/BMP8B/TP53BP2/TCF7	0.117305921041321
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/342	47/9376	1.16660445439841	SOCS3/PKM	0.222780225511716
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/342	158/9376	1.04108372196314	YWHAB/GADD45B/GADD45A/CDKN1A/GADD45G/CDKN2B	0.101330134973195
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/342	75/9376	1.0966081871345	CGA/PLCB1/TG	0.163432487253167
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/342	20/9376	1.37076023391813	SOAT1	0.322939885433011
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/342	104/9376	1.05443094916779	DGKI/PEMT/SGMS2/CHKB	0.108601172454
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/342	105/9376	1.04438874965191	ACTG1/ITGAV/ITGB1/CACNB3	0.0889944491094889
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/342	133/9376	1.03064679241965	GADD45B/GADD45A/CDKN1A/GADD45G/CDKN2B	0.0692568953076435
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/342	79/9376	1.04108372196314	CYP1B1/AKR7A2/GSTM1	0.0713461528178953
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/342	22/9376	1.2461456671983	ALDH9A1	0.224886559968657
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/342	80/9376	1.0280701754386	PLCG2/PDGFRB/FGF2	0.0490569689312227
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/342	109/9376	1.00606255700413	NFKBIA/SOCS3/GFPT2/PPP1R3C	0.0123867721996546
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/342	195/9376	0.984135552556605	ACTG1/SLC25A6/PLCG2/HDAC9/PLCB1/RAC1/VWF	-0.0435567944400937
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/342	23/9376	1.19196542079837	PCYOX1	0.179337084110628
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/342	139/9376	0.986158441667718	CALM1/MMP2/GNAI1/PLCB1/KRT34	-0.0319878877785163
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/342	168/9376	0.979114452798663	CSH1/SOCS3/CDKN1A/PDGFRB/AOX1/IL10RA	-0.0531467230765705
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/342	82/9376	1.00299529311083	NME2/GSTM1/TYMP	0.00530033803202498
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/342	53/9376	1.03453602559859	AP2M1/PLCB1	0.0490558831119136
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/342	83/9376	0.990911012470936	NFKBIA/CCL4L2/IFI16	-0.0161821131388205
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/342	55/9376	0.996916533758639	PSAP/SGMS2	-0.00446218874950185
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/342	115/9376	0.953572336638698	GNG4/GNAI1/PLCB1/GNG5	-0.0974665184144733
NA	NA	hsa04519	Cadherin signaling	14/342	404/9376	0.950031845289792	VIM/ACTG1/NFKBIA/YWHAB/RRAS/CTNND2/ARPC2/RHOA/PDGFRB/RAC1/KRT34/VAV1/TCF7/GABRE	-0.199755161422737
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/342	119/9376	0.921519484986977	NFKBIA/SOCS3/CXCL1/ICAM1	-0.167632739063935
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/342	323/9376	0.933644741368385	VIM/CYP1B1/CD44/PLCG2/RHOA/CDKN1A/PDGFRB/DDIT4/ABCB1/ZEB2/MARCKS	-0.236123382188692
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/342	28/9376	0.979114452798663	ACAA2	-0.0215339732978651
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/342	28/9376	0.979114452798663	GGH	-0.0215339732978651
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/342	28/9376	0.979114452798663	ATP6V1D	-0.0215339732978651
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/342	60/9376	0.913840155945419	PLCG2/RAC1	-0.130264008321964
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/342	181/9376	0.908791315304837	CALM1/RHOA/HLA-DQB1/HLA-DPA1/IL10RA/LSP1	-0.241078378455408
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/342	61/9376	0.89885916978238	FTL/MT2A	-0.154190866927265
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/342	29/9376	0.945351885460778	RASSF4	-0.0573451520104134
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/342	29/9376	0.945351885460778	CALM1	-0.0573451520104134
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/342	93/9376	0.884361441237502	CALM1/PLCB1/LYZ	-0.218051268479422
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/342	154/9376	0.890104047998785	NME2/VKORC1/RDH12/GGH/NQO1	-0.267539644187195
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/342	63/9376	0.870323958043256	ALDH9A1/PRDM6	-0.200929575922958
NA	NA	hsa04382	Cornified envelope formation	7/342	217/9376	0.884361441237502	S100A4/S100A16/PCSK6/LAMC2/S100A10/KRT34/ABHD5	-0.335325943959465
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/342	31/9376	0.884361441237502	ALDH9A1	-0.125473644442002
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/342	31/9376	0.884361441237502	ALDH9A1	-0.125473644442002
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/342	31/9376	0.884361441237502	SEC61B	-0.125473644442002
NA	NA	hsa04981	Folate transport and metabolism	1/342	31/9376	0.884361441237502	FOLR2	-0.125473644442002
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/342	32/9376	0.85672514619883	LDHA	-0.157956388810449
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/342	32/9376	0.85672514619883	IGBP1	-0.157956388810449
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/342	66/9376	0.830763778132199	CYP1B1/CYP11A1	-0.26844115373738
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/342	163/9376	0.840957198722778	CXCL8/NFKBIA/NFATC1/YWHAB/CDKN1A	-0.398534507561061
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/342	68/9376	0.806329549363605	RDH12/AOX1	-0.311851818031896
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/342	68/9376	0.806329549363605	RUNX1/TCF7	-0.311851818031896
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/342	34/9376	0.806329549363605	POLR2J2	-0.220110894262375
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/342	34/9376	0.806329549363605	RORB	-0.220110894262375
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/342	134/9376	0.818364318757092	CALM1/RHOA/AGTR1/PLCB1	-0.412030373856927
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/342	70/9376	0.783291562238931	CYP1B1/GSTM1	-0.354080463728075
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/342	36/9376	0.761533463287849	GCNT4	-0.278909883840116
NA	NA	hsa04082	Neuroactive ligand signaling	6/342	199/9376	0.826589085779776	GNG4/GRIA3/GNAI1/PLCB1/GNG5/GABRE	-0.481073293871309
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/342	168/9376	0.815928710665553	FTL/PPIA/SLC25A6/CHMP2B/TNFRSF10B	-0.468399786048176
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/342	72/9376	0.761533463287849	CXCL8/NFKBIA	-0.395200504108046
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/342	37/9376	0.740951477793583	GFPT2	-0.307178235625255
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/342	37/9376	0.740951477793583	AOX1	-0.307178235625255
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/342	37/9376	0.740951477793583	GFPT2	-0.307178235625255
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/342	73/9376	0.751101498037331	GSTM1/AOX1	-0.415365910274965
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/342	38/9376	0.721452754693752	GFPT2	-0.334751382648486
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/342	108/9376	0.761533463287849	EEF1A1/RAN/EIF4A3	-0.484958926550785
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/342	75/9376	0.731072124756335	GAPDH/PKM	-0.454946447567532
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/342	75/9376	0.731072124756335	CDKN1A/GSTM1	-0.454946447567532
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/342	39/9376	0.702953966111861	SARDH	-0.361668787633824
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/342	76/9376	0.721452754693752	UBC/CPT1C	-0.474376141005548
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/342	143/9376	0.76685887212203	HLA-DQB1/HLA-DPA1/C9/C2	-0.546605682397953
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/342	41/9376	0.668663528740551	SARDH	-0.413678221868677
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/342	78/9376	0.702953966111861	PLCG2/PLCB1	-0.512548464341935
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/342	78/9376	0.702953966111861	BTG1/PABPC4	-0.512548464341935
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/342	79/9376	0.69405581464209	AP2M1/ATP6V1D	-0.531303873146598
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/342	43/9376	0.637562899496804	ABCG8	-0.463462809921712
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/342	117/9376	0.702953966111861	ACTG1/CDK2AP1/INO80D	-0.629061773579463
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/342	44/9376	0.623072833599149	MGAT4C	-0.487590304091373
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/342	44/9376	0.623072833599149	DYNLL1	-0.487590304091373
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/342	217/9376	0.758024092489288	CYP1B1/GNAI1/GSTM1/DLL1/DLL3/FGF2	-0.701675984808211
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/342	83/9376	0.660607341647291	PRDX5/PRDX1	-0.604257666586811
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/342	250/9376	0.767625730994152	CTSL/AP2M1/PSAP/LAPTM5/ATP6V1D/ARL8B/SNAP29	-0.724563507059025
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/342	156/9376	0.702953966111861	NFKBIA/SOCS3/YWHAB/CDKN1A	-0.727912613245611
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/342	191/9376	0.717675515140382	GNG4/CALM1/GNAI1/HDAC9/GNG5	-0.766980452983153
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/342	87/9376	0.630234590307186	COX4I1/CACNB3	-0.674155489017128
NA	NA	hsa03272	Virion - Hepatitis viruses	1/342	48/9376	0.571150097465887	CD9	-0.57954920418052
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/342	48/9376	0.571150097465887	PLCB1	-0.57954920418052
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/342	49/9376	0.559493973027808	GNAI1	-0.601502663158773
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/342	50/9376	0.548304093567252	ALDH9A1	-0.623077544106769
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/342	90/9376	0.609226770630279	ABCB1/ABCG8	-0.72475357637065
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/342	90/9376	0.609226770630279	NFKBIA/NFATC1	-0.72475357637065
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/342	54/9376	0.507688975525233	LDHA	-0.70589570573069
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/342	56/9376	0.489557226399332	MGAT4C	-0.745404079526992
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/342	138/9376	0.595982710399186	CALM1/SOCS3/PPP1R3C	-0.930270315753416
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/342	59/9376	0.464664486073942	GSTM1	-0.802551039205335
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/342	103/9376	0.532334071424516	PABPC4/EIF4A3	-0.928544798379672
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/342	62/9376	0.442180720618751	CRYAB	-0.857392926717233
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/342	63/9376	0.435161979021628	PTGDS	-0.875201481382388
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/342	63/9376	0.435161979021628	POLR2J2	-0.875201481382388
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/342	116/9376	0.472675942730389	GAPDH/PKM	-1.11188464905804
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/342	158/9376	0.520541860981568	RHOA/ATP6V1D/DDIT4	-1.18255006166016
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/342	86/9376	0.318781449748402	PLCB1	-1.23477117464871
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/342	86/9376	0.318781449748402	PLCB1	-1.23477117464871
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/342	136/9376	0.403164774681803	NFKBIA/RACK1	-1.36410111542317
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/342	138/9376	0.397321806932791	CALM1/YWHAB	-1.38769712928939
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/342	183/9376	0.44942958489119	REXO2/RAN/PWP2	-1.46341813903254
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/342	144/9376	0.380766731643925	FGF2/TCF7	-1.45695546581413
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/342	243/9376	0.451279089355763	DDX5/HNRNPC/EIF4A3/SRSF3	-1.68619022250992
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/342	110/9376	0.24922913343966	GNAI1	-1.54104831294803
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/342	370/9376	0.518666034455508	CGA/CSH1/LHCGR/GRIA3/AGTR1/BDKRB1/GABRE	-1.83797689567275
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/342	122/9376	0.224714792445595	CPT1C	-1.67700869200621
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/342	449/9376	0.122116724625223	CALM1/OR5AU1	-3.70907680553587