category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	69/285	238/9376	9.53772666961522	CFD/RPL3/RPL10/RPS2/RPLP0/RPS4X/RPL13A/RPL12/RPL18A/RPL7A/RPS18/JUN/RPL5/RPL6/RPS9/RPL10A/RPL9/RPS5/RPL37A/RPS27/RPS6/RPS20/RPL29/RPL7/RPL15/RPS3/RPL27A/RPL23A/RPL8/RPL13/RPS23/RPS29/RPS7/RPS8/RPS13/RPL37/C1R/RPS14/RPS17/RPL18/RPS11/RPL11/RPS16/NFKBIA/RPS28/C1S/RPL30/RPL36/RPL17/RPL24/RPL31/RPL4/RPL14/RPS3A/RPL35A/RPL39/RPL32/RPS25/RPL22/CXCL8/RPSA/STAT3/RPL34/RPS21/ACE2/RPLP2/RPL27/STAT1/C1QA	23.621495404116
Genetic Information Processing	Translation	hsa03010	Ribosome	60/285	222/9376	8.891417733523	RPL3/RPL10/RPS2/RPLP0/RPS4X/RPL13A/RPL12/RPL18A/RPL7A/RPS18/RPL5/RPL6/RPS9/RPL10A/RPL9/RPS5/RPL37A/RACK1/RPS27/RPS6/RPS20/RPL29/RPL7/RPL15/RPS3/RPL27A/RPL23A/RPL8/RPL13/RPS23/RPS29/RPS7/RPS8/RPS13/RPL37/RPS14/RPS17/RPL18/RPS11/RPL11/RPS16/RPS28/RPL30/RPL36/RPL17/RPL24/RPL31/RPL4/RPL14/RPS3A/RPL35A/RPL39/RPL32/RPS25/RPL22/RPSA/RPL34/RPS21/RPLP2/RPL27	21.0682423741732
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/285	89/9376	6.65357776463631	COL6A1/COL1A1/COL6A3/COL1A2/COL6A2/SPP1/FN1/LAMA2/TNXB/LAMB1/COL4A2/COL4A1/THBS2/HSPG2/ITGB8/GP1BB/TNC/LAMC2	9.48817945436581
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/285	233/9376	3.6710488668022	FBLN1/COL3A1/VCAN/COL6A1/VIM/COL1A1/COL6A3/COL1A2/COL6A2/FBLN2/ACTG1/FN1/TPM2/LAMA2/COL4A2/COL4A1/THBS2/SYNPO2/COL5A1/HSPG2/PDLIM1/ITGB8/ENO2/COL5A2/SSPN/EMD	7.31000499063407
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/285	103/9376	5.42980752853006	COL3A1/COL1A1/COL1A2/FN1/HSPB1/LAMA2/LAMB1/COL4A2/CXCL8/COL4A1/RAB7A/IL1R1/CXCL1/RAB7B/ARG2/LAMC2/GNA14	8.00378803539351
NA	NA	hsa04518	Integrin signaling	19/285	154/9376	4.05887445887446	COL6A1/COL1A1/COL6A3/COL1A2/COL6A2/SPP1/ACTG1/FN1/LAMA2/TNXB/LAMB1/COL4A2/COL4A1/PDGFRB/THBS2/VCAM1/ITGB8/TNC/LAMC2	6.77659754330672
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/285	203/9376	3.4032667876588	JUN/COL6A1/COL1A1/COL6A3/COL1A2/COL6A2/SPP1/ACTG1/PAK3/FN1/LAMA2/TNXB/LAMB1/COL4A2/COL4A1/CAV1/PDGFRB/THBS2/ITGB8/TNC/LAMC2	6.12909772825416
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/285	101/9376	4.560152857391	COL3A1/JUN/COL1A1/COL1A2/FN1/COL4A2/CXCL8/EGR1/COL4A1/STAT3/FOXO1/MMP2/VCAM1/STAT1	6.3690493229869
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/285	103/9376	3.83280531425652	COL3A1/COL6A1/COL1A1/COL6A3/COL1A2/COL6A2/COL15A1/COL4A2/COL4A1/COL5A1/ACE2/COL5A2	5.11832018317262
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/285	362/9376	2.18109915673161	COL6A1/COL1A1/RPS6/CSH1/COL6A3/COL1A2/COL6A2/SPP1/FN1/LAMA2/FGF10/TNXB/LAMB1/GNG4/COL4A2/COL4A1/PDGFRB/THBS2/MAGI1/FGF7/ITGB8/IL7R/TNC/LAMC2	4.05773898177911
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	22/285	333/9376	2.17345766819451	COL6A1/COL1A1/COL6A3/COL1A2/COL6A2/SPP1/FN1/LAMA2/TNXB/LAMB1/COL4A2/COL4A1/PDGFRB/HLA-B/THBS2/FOXO1/TCF7L2/MAGI1/ITGB8/STAT1/TNC/LAMC2	3.86042854236219
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/285	95/9376	3.11667590027701	JUN/CXCL12/HLA-DRB5/CCL3L1/CXCL8/IL15/CXCL1/CD28/CTLA4	3.6713096914387
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/285	142/9376	2.54845564615765	JUN/ACTG1/TXN/SQSTM1/CAV1/IL1R1/MMP2/VCAM1/MEF2C/PLAT/MAP3K5	3.29192738212737
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/285	105/9376	2.81984962406015	CCL4L2/CXCL12/NFKBIA/CXCL8/IL1R1/CXCL1/VCAM1/CARD10/TRAF1	3.32023712742273
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/285	70/9376	3.28982456140351	HLA-DRB5/ACTG1/LAMA2/CAV1/HLA-B/CD28/SSPN	3.40464585961487
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/285	54/9376	3.65536062378168	CGA/HLA-DRB5/HLA-B/CD28/TG/CTLA4	3.46471950332908
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/285	56/9376	3.52481203007519	EEF1A1/EEF1G/NFKBIA/CXCL8/CXCL1/CLK1	3.35519176727744
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/285	93/9376	2.82995661196001	NFKBIA/FN1/LAMA2/LAMB1/COL4A2/COL4A1/TRAF1/LAMC2	3.14007724089938
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/285	204/9376	2.09645682834537	DDX5/COL1A1/RPS6/COL1A2/ACTG1/TIMP3/FN1/TWIST2/CAV1/STAT3/MMP2/HSPG2/PTCH1	2.80334685938152
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/285	160/9376	2.26175438596491	VCAN/HLA-DRB5/HLA-B/NLGN1/NLGN4X/ICOS/VCAM1/ITGB8/CD28/CD6/CTLA4	2.85013755483602
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/285	86/9376	2.67776417788658	ACTG1/LAMA2/CACNB2/TCF7L2/ITGB8/SSPN/EMD	2.76741649657247
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/285	67/9376	2.94611154752553	LDHA/GAPDHS/ENO2/ALDH3B1/GPI/ALDH9A1	2.83045239619666
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/285	196/9376	2.01417830290011	JUN/UBC/MAP1LC3B/NFKBIA/GNG4/UBB/CXCL8/HLA-B/STAT3/TCF7L2/CXCL1/STAT1	2.5405236930273
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/285	50/9376	3.28982456140351	CXCL12/HLA-DRB5/IL15/ICOS/CD28	2.87436387073232
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/285	50/9376	3.28982456140351	HBB/CXCL8/THBS2/VCAM1/LRP1	2.87436387073232
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/285	130/9376	2.27757085020243	COL3A1/JUN/COL1A1/COL1A2/NFKBIA/GNG4/COL4A2/COL4A1/MMP2	2.59705989105473
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/285	109/9376	2.41455013680991	JUN/HLA-DRB5/NFKBIA/CD3D/STAT3/IL1R1/RORA/STAT1	2.6300514949962
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/285	155/9376	2.12246745897001	C1R/HLA-DRB5/ACTG1/RAB7A/HLA-B/THBS2/TUBB3/RAB7B/OLR1/TUBB4B	2.49489824078464
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/285	52/9376	3.16329284750337	APOE/ABCA1/MYLIP/LIPG/LRP1	2.76960664865227
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/285	227/9376	1.88404049772007	JUN/MT-CO3/SOD2/MT-CYB/NFKBIA/MT-ATP8/SLC25A6/MT-CO1/CYP1B1/MT-ND3/MT-ND4L/MAP3K5/CAT	2.3872643606701
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/285	205/9376	1.92575096277279	COL3A1/MT-CO3/COL1A1/COL1A2/MT-CYB/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/MT-ND4L/MMP2/GFPT2	2.37282109946837
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/285	119/9376	2.21164676396875	JUN/NFKBIA/IL15/SOCS3/CXCL1/VCAM1/TRAF1/MAP3K5	2.35513938325345
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/285	99/9376	2.32613857877016	ACTG1/TPM2/LAMA2/CACNB2/ITGB8/SSPN/EMD	2.34857788795044
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/285	144/9376	2.05614035087719	NFKBIA/CXCL8/FOXO1/TCF7L2/CXCL1/SCD5/C1QA/ALDH9A1/MAP3K5	2.26129500307563
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/285	268/9376	1.71856506938989	MT-CO3/UBC/MT-CYB/TXN/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/UBB/MT-ND4L/TUBB3/PARK7/MAP3K5/TUBB4B	2.11312032352824
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/285	103/9376	2.23580309998297	JUN/NFKBIA/CCL3L1/CD3D/CXCL8/C1QA/GNA14	2.23285233095173
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/285	42/9376	3.13316624895572	CYP1B1/AOX1/ALDH9A1/CAT	2.45311376770393
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/285	42/9376	3.13316624895572	FTL/MAP1LC3B/FTH1/SAT1	2.45311376770393
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	13/285	248/9376	1.72450481041313	JUN/RPS3/ACTG1/TXN/PAK3/NFKBIA/CXCL8/RAB7A/TUBB3/ANXA2/TCF7L2/RAB7B/TUBB4B	2.04730024018116
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/285	105/9376	2.19321637426901	JUN/UBC/MAP1LC3B/SQSTM1/UBB/RAB7A/RAB7B	2.17697179729491
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/285	105/9376	2.19321637426901	ACTG1/TPM2/LAMA2/CACNB2/ITGB8/SSPN/EMD	2.17697179729491
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/285	109/9376	2.11273136970868	JUN/CCL4L2/SPP1/NFKBIA/CCL3L1/CXCL8/STAT1	2.06888446459126
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/285	66/9376	2.4922913343966	JUN/HLA-DRB5/STAT3/RORA/STAT1	2.15403613084639
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/285	88/9376	2.24306220095694	CFD/C1R/C1S/PROCR/PLAT/C1QA	2.07431798414418
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/285	112/9376	2.05614035087719	HLA-DRB5/NFKBIA/LAMA2/LAMB1/STAT3/STAT1/LAMC2	1.99082741691269
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/285	90/9376	2.19321637426901	JUN/NFKBIA/CD3D/STAT3/CD28/STAT1	2.01385574763019
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/285	216/9376	1.67537361923327	JUN/SOD2/NFKBIA/CCL3L1/ABCA1/CXCL8/STAT3/CXCL1/VCAM1/OLR1/MAP3K5	1.77797426567106
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/285	94/9376	2.09988801791713	JUN/NFKBIA/CXCL8/CXCL1/S100A9/SRSF1	1.89755273826943
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/285	193/9376	1.70457231160804	CCL4L2/CXCL12/NFKBIA/CCL3L1/GNG4/CXCL8/STAT3/CXCL1/STAT1/CXCR6	1.75111300684217
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/285	122/9376	1.887604256543	JUN/PAK3/NFKBIA/CD3D/ICOS/CD28/CTLA4	1.74717651462156
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/285	99/9376	1.99383306751728	CFD/C1R/HLA-DRB5/C1S/KRT19/C1QA	1.76006821915221
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/285	201/9376	1.63672863751418	DDX5/NFKBIZ/PBX1/CXCL8/FOXO1/BCL11B/MEF2C/PLAT/GRIA3/TRAF1	1.61566610753136
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/285	308/9376	1.49537480063796	TGM2/MT-CO3/SOD2/MT-CYB/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/MT-ND4L/TUBB3/GRIA3/AP2A2/MAP3K5/TUBB4B	1.5651492318292
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/285	78/9376	2.10886189833558	JUN/C1R/C1S/CXCL8/C1QA	1.74113413779406
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/285	78/9376	2.10886189833558	EEF1A1/JUN/HLA-DRB5/NFKBIA/STAT1	1.74113413779406
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/285	178/9376	1.66339444115908	SFRP2/JUN/SERPINF1/APCDD1/SFRP4/TCF7L2/MCC/PRICKLE2/CTBP1	1.58211251492181
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/285	157/9376	1.67634372555593	ABCA1/PBX1/SLC16A1/RAB7A/RAB7B/ARG2/C1QA/LRP1	1.51313481362878
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/285	38/9376	2.59722991689751	AOX1/NAPRT/NNMT	1.74676523174641
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/285	38/9376	2.59722991689751	CD3D/ICOS/IL7R	1.74676523174641
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/285	61/9376	2.15726200747771	FTL/FTH1/MT2A/MT1E	1.60548932709108
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/285	39/9376	2.5306342780027	HLA-DRB5/HLA-B/CD28	1.69590803728291
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/285	136/9376	1.69329205366357	JUN/RACK1/NFKBIA/CD3D/STAT3/CD28/STAT1	1.44195574060542
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/285	87/9376	1.89070377092156	MT-CO3/MT-CYB/MT-CO1/TPM2/CACNB2	1.47778303031494
NA	NA	hsa04382	Cornified envelope formation	10/285	217/9376	1.51604818497858	S100A6/S100A4/S100A16/KRT19/COL4A2/COL4A1/S100A9/ABHD5/LAMC2/KRT8	1.36175297156076
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/285	275/9376	1.43555980861244	MT-CO3/MT-CYB/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/EGR1/MT-ND4L/CAV1/TUBB3/C1QA/TUBB4B	1.29799143692146
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/285	140/9376	1.64491228070175	RPS6/SPP1/MAP1LC3B/GNG4/EGR1/MEF2C/PLAT	1.36120940805953
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/285	168/9376	1.56658312447786	CSH1/AOX1/PDGFRB/IL15/STAT3/SOCS3/IL7R/STAT1	1.31201215915429
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/285	22/9376	2.99074960127592	ALDH3B1/ALDH9A1	1.65512780414524
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/285	44/9376	2.24306220095694	HLA-DRB5/HLA-B/CD28	1.46330236035838
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/285	93/9376	1.768722882475	JUN/HLA-DRB5/NFKBIA/CD3D/STAT1	1.31907456823959
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/285	23/9376	2.86071700991609	ENPEP/ACE2	1.5818708310818
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/285	200/9376	1.48042105263158	JUN/RPS3/ACTG1/PAK3/NFKBIA/CXCL8/TUBB3/IL1R1/TUBB4B	1.21594117524804
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/285	45/9376	2.19321637426901	HLA-DRB5/HLA-B/CD28	1.42057316331724
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/285	232/9376	1.41802782819117	CXCL12/ACTG1/PAK3/TMSB4X/FN1/FGF10/GSN/PDGFRB/FGF7/ITGB8	1.14151945309219
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/285	71/9376	1.85342228811465	CGA/STAT3/SOCS3/STAT1	1.27801869190212
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/285	71/9376	1.85342228811465	JUN/NFKBIA/CXCL8/CXCL1	1.27801869190212
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/285	48/9376	2.05614035087719	BCAT1/AOX1/ALDH9A1	1.29882376031541
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/285	235/9376	1.39992534527809	MT-CO3/RPS6/MT-CYB/ACTG1/MT-ATP8/MT-CO1/MT-ND3/PRKG1/MT-ND4L/MAP3K5	1.09930510410291
Organismal Systems	Immune system	hsa04611	Platelet activation	6/285	126/9376	1.56658312447786	COL3A1/COL1A1/COL1A2/ACTG1/PRKG1/GP1BB	1.13365336259029
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/285	100/9376	1.64491228070175	CCL4L2/CXCL12/CCL3L1/CXCL8/CXCL1	1.14794879466469
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/285	100/9376	1.64491228070175	HLA-DRB5/CD3D/IL1R1/GP1BB/IL7R	1.14794879466469
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/285	154/9376	1.49537480063796	JUN/EEF2/ACTG1/MYL6/CACNB2/RGS2/MEF2C	1.09744799995959
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/285	50/9376	1.97389473684211	SAT1/ARG2/ALDH9A1	1.2225075635312
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/285	298/9376	1.32476156835041	CSH1/CCL4L2/CXCL12/CCL3L1/IL32/CXCL8/IL15/IL1R1/CXCL1/IL7R/TNFRSF9/CXCR6	1.00874155568358
NA	NA	hsa04517	IgSF CAM signaling	12/285	299/9376	1.32033092765358	ACTG1/PAK3/MYL6/NLGN1/TUBB3/FOXO1/MAGI1/NLGN4X/SH2D1A/CD28/CD48/TUBB4B	0.996702476103811
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/285	76/9376	1.731486611265	UBC/PLIN2/SCD5/OLR1	1.13363681863098
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/285	157/9376	1.46680075986144	JUN/MT-CO3/MT-CYB/MT-CO1/CXCL8/SOCS3/MAP3K5	1.04433951862883
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/285	29/9376	2.26884452510587	RASSF4/RASSF2	1.21163978996445
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/285	106/9376	1.55180403839788	NFKBIA/PDGFRB/FOXO1/TCF7L2/PLAT	1.01157987221218
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/285	163/9376	1.41280809385427	JUN/NFKBIA/CXCL8/DDX3X/STAT3/HSPG2/STAT1	0.941333923151178
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	14/285	368/9376	1.25156369183829	MT-CO3/MT-CYB/ACTG1/MAP1LC3B/MT-ATP8/MT-CO1/MT-ND3/SQSTM1/HNRNPA1/MT-ND4L/TUBB3/MAP3K5/TUBB4B/CAT	0.87168569614261
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/285	109/9376	1.5090938355062	NFKBIA/STAT3/SOCS3/FOXO1/GFPT2	0.946550403781374
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/285	253/9376	1.30032591359822	JUN/UBC/ACTG1/MAP1LC3B/NFKBIA/SQSTM1/UBB/CXCL8/IL1R1/FOXO1	0.857405903351827
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/285	56/9376	1.76240601503759	GLI2/SCUBE2/PTCH1	1.01315201072642
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/285	224/9376	1.3218045112782	JUN/HLA-DRB5/NFKBIA/SLC25A6/CD3D/EGR1/IL15/HLA-B/IL1R1	0.863098517828086
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/285	31/9376	2.12246745897001	ALDH3B1/ALDH9A1	1.10832516138136
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/285	110/9376	1.49537480063796	RPS6/TIMP1/LDHA/STAT3/ENO2	0.925308058666579
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/285	138/9376	1.43035850495805	MT-CO3/MT-CYB/MT-ATP8/MT-CO1/MT-ND3/MT-ND4L	0.901743859625261
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/285	227/9376	1.30433572919082	CCL4L2/CXCL12/NFKBIA/CCL3L1/GNG4/CXCL8/HLA-B/STAT3/IL1R1	0.821828685280256
Human Diseases	Immune disease	hsa05310	Asthma	2/285	32/9376	2.05614035087719	HLA-DRB5/PRG2	1.05957682089215
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/285	142/9376	1.39006671608599	JUN/NFKBIA/SQSTM1/IL1R1/SOCS3/STAT1	0.829259337667357
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/285	59/9376	1.67279214986619	CGA/PRKG1/ABHD5	0.917848733255826
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/285	173/9376	1.33114288611703	HLA-DRB5/ACTG1/NFKBIA/SLC25A6/CXCL8/SOCS3/STAT1	0.778351935122303
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/285	34/9376	1.93519091847265	RORA/RORB	0.967212826408199
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/285	205/9376	1.28383397518186	JUN/VIM/HLA-DRB5/NFKBIA/CD3D/HLA-B/STAT3/STAT1	0.727503693909517
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/285	89/9376	1.47857283658585	PRKG1/PDGFRB/TUBB3/TUBB4B	0.80317015959601
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/285	62/9376	1.5918505942275	SOD2/FOXO1/CAT	0.82783170480569
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/285	480/9376	1.16514619883041	MT-CO3/UBC/MT-CYB/MAP1LC3B/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/SQSTM1/UBB/MT-ND4L/TUBB3/GRIA3/PARK7/MAP3K5/TUBB4B/CAT	0.657648831612301
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/285	63/9376	1.56658312447786	TCF7L2/GLI2/PTCH1	0.798898025165856
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/285	180/9376	1.27937621832359	HLA-DRB5/NFKBIA/HLA-B/SOCS3/PILRA/SRSF1/STAT1	0.670082760736811
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/285	37/9376	1.7782835467046	AOX1/ALDH3B1	0.839828798670856
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/285	37/9376	1.7782835467046	GFPT2/GPI	0.839828798670856
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/285	37/9376	1.7782835467046	HBB/VCAM1	0.839828798670856
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/285	93/9376	1.41497830598	JUN/CGA/EGR1/MMP2	0.712073677352994
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/285	65/9376	1.51838056680162	CGA/SPP1/TRPC4	0.742522240639942
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/285	38/9376	1.731486611265	GFPT2/GPI	0.799969601450751
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/285	68/9376	1.45139318885449	ALDH1A3/AOX1/RDH12	0.661429422805912
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/285	187/9376	1.23148512993714	JUN/TXN/MAP1LC3B/NFKBIA/CXCL8/CXCL1/STAT1	0.566124584590953
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/285	69/9376	1.43035850495805	JUN/ARC/GRIA3	0.635261181314404
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/285	41/9376	1.60479246897732	CXCL8/MMP2	0.687137073837916
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/285	70/9376	1.40992481203008	NFKBIA/STAT3/SOCS3	0.609500324852904
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/285	15/9376	2.19321637426901	B4GALNT1	0.818853011732777
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/285	72/9376	1.37076023391813	NFKBIA/CXCL8/DDX3X	0.559148010743507
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/285	133/9376	1.23677615090357	SOD2/STAT3/FOXO1/IL7R/CAT	0.486922159630356
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/285	73/9376	1.3519826964672	FGF10/PDGFRB/FGF7	0.534531708733208
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/285	16/9376	2.05614035087719	ALDH3B1	0.748593310442079
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/285	166/9376	1.18909321496512	SLC25A6/PRKG1/RGS2/MEF2C/EDNRA/ADRA2C	0.435213555757307
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/285	388/9376	1.10226080665581	MT-CO3/APOE/MT-CYB/MT-ATP8/SLC25A6/MT-CO1/MT-ND3/MT-ND4L/TUBB3/BACE2/MAP3K5/TUBB4B/LRP1	0.364246833034897
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/285	75/9376	1.3159298245614	BCAT1/ENO2/ARG2	0.486360924310269
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/285	168/9376	1.1749373433584	FTL/FTH1/SLC25A6/SQSTM1/STAT3/STAT1	0.405094877804346
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/285	137/9376	1.20066589832245	JUN/ACTG1/NFKBIA/TRAF1/MAP3K5	0.418912783051647
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/285	169/9376	1.16798505138586	UBC/MAP1LC3B/SQSTM1/UBB/RAB7A/RAB7B	0.390172949432854
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/285	138/9376	1.19196542079837	JUN/ACTG1/NFKBIA/FN1/CXCL8	0.402231250157788
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/285	46/9376	1.43035850495805	FTL/FTH1	0.518048861278203
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/285	170/9376	1.16111455108359	JUN/ACTG1/MYL6/RAB13/MAGI1/MAP3K5	0.375340977150129
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/285	47/9376	1.39992534527809	LDHA/ALDH9A1	0.486645318877346
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/285	78/9376	1.26531713900135	ACTG1/FN1/CAV1	0.416600776661637
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/285	205/9376	1.12335472828412	JUN/NFKBIA/GSN/DDX3X/HLA-B/STAT3/TRAF1	0.316174342519803
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/285	143/9376	1.15028830818305	C1R/HLA-DRB5/C1S/CD28/C1QA	0.320644677898026
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/285	80/9376	1.23368421052632	RPS6/PDGFRB/STAT3	0.37164521406049
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/285	49/9376	1.34278553526674	COLGALT2/GALNT13	0.425943287375269
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/285	83/9376	1.18909321496512	SOD2/PRDX5/CAT	0.306365080385702
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/285	212/9376	1.08626282687852	ACTG1/FGF10/DOCK4/PDGFRB/MAGI1/FGF7/MAGI3	0.2249320366694
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/285	116/9376	1.13442226255293	CXCL12/ACTG1/MMP2/VCAM1	0.257927080071883
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/285	52/9376	1.26531713900135	CGA/CYP1B1	0.339678519728657
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/285	21/9376	1.56658312447786	UST	0.460207429765665
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/285	21/9376	1.56658312447786	BCAT1	0.460207429765665
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/285	184/9376	1.07276887871854	SEMA5A/CXCL12/PAK3/TRPC4/EPHA4/PTCH1	0.176502892123083
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/285	54/9376	1.21845354126056	LDHA/BCAT1	0.285038588807135
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/285	120/9376	1.0966081871345	JUN/NFKBIA/BEX3/MAP3K5	0.188579778792348
NA	NA	hsa04081	Hormone signaling	7/285	219/9376	1.05154209725226	CGA/CSH1/GNG4/PRKG1/STAT3/ADRA2C/GNA14	0.13665004394788
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/285	23/9376	1.43035850495805	ARG2	0.365865181149606
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/285	122/9376	1.07863100373886	CSH1/STAT3/SOCS3/STAT1	0.154778711391852
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/285	90/9376	1.0966081871345	SOD2/FOXO1/CAT	0.163050857434085
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/285	157/9376	1.04771482847246	SLC25A6/SQSTM1/CXCL8/HLA-B/FOXO1	0.106748928628934
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/285	91/9376	1.08455754771544	JUN/NFKBIA/IFITM1	0.143510725773438
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/285	91/9376	1.08455754771544	GNG4/PDE8B/PDE10A	0.143510725773438
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/285	226/9376	1.01897220928427	JUN/CGA/NFKBIA/PDE10A/GRIA3/EDNRA/PTCH1	0.0511168188552493
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/285	59/9376	1.11519476657746	NME2/NT5C3B	0.157153097880009
Cellular Processes	Cell motility	hsa04814	Motor proteins	6/285	194/9376	1.01747151383614	ACTG1/MYL6/TPM2/BICDL1/TUBB3/TUBB4B	0.0435376512839472
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/285	60/9376	1.0966081871345	PRKG1/GRIA3	0.132915936988469
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/285	300/9376	0.986947368421053	JUN/HSPB1/FGF10/CACNB2/PDGFRB/IL1R1/FGF7/MEF2C/MAP3K5	-0.0406830685954838
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/285	27/9376	1.21845354126056	SCD5	0.201261465532715
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/285	62/9376	1.061233729485	DTX4/CTBP1	0.0856486808758612
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/285	97/9376	1.01747151383614	GNG4/PRKG1/GRIA3	0.0306244329241339
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/285	63/9376	1.04438874965191	COLGALT2/ALDH9A1	0.0625893763941009
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/285	65/9376	1.01225371120108	LIPG/ALDH9A1	0.0175520721259259
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/285	65/9376	1.01225371120108	PBX1/PDE8B	0.0175520721259259
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/285	30/9376	1.0966081871345	ACLY	0.0938347953012978
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/285	31/9376	1.061233729485	GPI	0.0604622277208141
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/285	31/9376	1.061233729485	ALDH9A1	0.0604622277208141
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/285	31/9376	1.061233729485	CAT	0.0604622277208141
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/285	68/9376	0.967595459236326	STAT3/TCF7L2	-0.0474825877368669
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/285	105/9376	0.939949874686717	JUN/NFKBIA/STAT1	-0.109558862960735
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/285	32/9376	1.0280701754386	LDHA	0.0281615101898245
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/285	70/9376	0.939949874686717	JUN/PAK3	-0.0892860588375862
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/285	214/9376	0.922380718150516	JUN/PAK3/NFKBIA/CD3D/GNG4/HLA-B	-0.20336846119347
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/285	33/9376	0.996916533758639	BCAT1	-0.00314163142803644
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/285	71/9376	0.926711144057326	LDHA/PDGFRB	-0.109751677577789
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/285	144/9376	0.913840155945419	SLC25A6/RORA/GRIA3/MAP3K5	-0.184476262709381
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/285	110/9376	0.897224880382775	THSD4/ID4/FMOD	-0.19197312073559
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/285	73/9376	0.901321797644797	AOX1/ALDH3B1	-0.149855741913051
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/285	148/9376	0.8891417733523	JUN/FGF10/TCF7L2/FGF7	-0.240684005891308
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/285	149/9376	0.883174378900271	MT-ND3/GNG4/MT-ND4L/GRIA3	-0.254509039429088
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/285	75/9376	0.877286549707602	CGA/TG	-0.188912291495015
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/285	36/9376	0.913840155945419	GPI	-0.091703298209546
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/285	36/9376	0.913840155945419	GALNT13	-0.091703298209546
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/285	37/9376	0.8891417733523	GFPT2	-0.11962469424226
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/285	37/9376	0.8891417733523	TCF7L2	-0.11962469424226
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/285	77/9376	0.854499886078833	STAT3/STAT1	-0.226982728062239
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/285	77/9376	0.854499886078833	NFKBIA/CTBP1	-0.226982728062239
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/285	115/9376	0.858215102974828	NACA/EGR1/MEF2C	-0.270864562484761
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/285	116/9376	0.850816696914701	ENO2/GPI/CAT	-0.286250305786348
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/285	154/9376	0.854499886078833	NME2/BCAT1/NAPRT/RDH12	-0.322339385877193
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/285	79/9376	0.832866977570509	CYP1B1/ALDH3B1	-0.264123252396826
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/285	155/9376	0.848986983588002	PBX1/PDE8B/TCF7L2/RBBP5	-0.335655261959752
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/285	156/9376	0.843544759334233	NFKBIA/STAT3/SOCS3/STAT1	-0.348890539211966
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/285	82/9376	0.802396234488661	HLA-DRB5/HLA-B	-0.318202104506141
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/285	41/9376	0.802396234488661	GRIA3	-0.224508207654132
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/285	122/9376	0.808973252804142	EEF2/FOXO1/SCD5	-0.376020556351384
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/285	122/9376	0.808973252804142	ACTG1/FOXO1/STAT1	-0.376020556351384
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/285	83/9376	0.792728809976749	CCL4L2/NFKBIA	-0.335816675414956
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/285	85/9376	0.774076367389061	NME2/NT5C3B	-0.370460692794084
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/285	43/9376	0.765075479396165	ALDH9A1	-0.273372096551971
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/285	43/9376	0.765075479396165	ABCA1	-0.273372096551971
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/285	86/9376	0.765075479396165	JUN/PAK3	-0.387500223414821
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/285	87/9376	0.756281508368623	JUN/TCF7L2	-0.404357837998332
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/285	45/9376	0.731072124756335	ABCA1	-0.320169694849451
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/285	128/9376	0.771052631578947	NME2/PDE8B/PDE10A	-0.461762828439757
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/285	47/9376	0.699962672639044	SOCS3	-0.36509754276051
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/285	323/9376	0.81481722883059	VIM/TIMP3/CYP1B1/TNXB/PDGFRB/STAT3/MARCKS/TNC	-0.59966378151275
NA	NA	hsa03272	Virion - Hepatitis viruses	1/285	48/9376	0.685380116959064	HSPG2	-0.386914276328732
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/285	133/9376	0.742065690542145	HLA-B/SH2D1A/CD48	-0.530433198295933
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/285	250/9376	0.789557894736842	CAV1/RAB7A/HLA-B/ARF4/IQSEC1/AP2A2	-0.597124168136351
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/285	134/9376	0.736527886881382	MYL6/PRKG1/EDNRA	-0.543884035212652
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/285	93/9376	0.707489152990002	ACTG1/TCF7L2	-0.501928104420198
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/285	93/9376	0.707489152990002	CST3/PRKG1	-0.501928104420198
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/285	49/9376	0.671392767633369	JUN	-0.408325411691061
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/285	254/9376	0.777123912142561	SLC25A6/FGF10/PDGFRB/FGF7/EDNRA/GNA14	-0.637584190318699
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/285	51/9376	0.645063639490884	ACTG1	-0.450000917131671
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/285	217/9376	0.758024092489288	JUN/CYP1B1/FGF10/STAT3/FGF7	-0.638528379113484
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/285	138/9376	0.715179252479024	RPS6/SOCS3/FOXO1	-0.596793968777158
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/285	139/9376	0.710034078000757	JUN/KRT19/MMP2	-0.609805207065274
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/285	98/9376	0.671392767633369	GSN/MARCKS	-0.578982198106245
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/285	53/9376	0.620721615359153	AP2A2	-0.490253185955818
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/285	99/9376	0.664611022505759	JUN/MMP2	-0.593970456040703
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/285	99/9376	0.664611022505759	JUN/PDGFRB	-0.593970456040703
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/285	142/9376	0.695033358042995	UBC/UBB/SOCS3	-0.648341489008649
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/285	55/9376	0.598149920255183	B4GALNT1	-0.529195800253979
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/285	57/9376	0.577162203755001	SCD5	-0.56692918152021
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/285	59/9376	0.55759738328873	TCF7L2	-0.60354253749581
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/285	150/9376	0.657964912280702	FGF10/TCF7L2/FGF7	-0.747673183432755
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/285	107/9376	0.614920478767011	LDHA/FOXO1	-0.709296979235591
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/285	60/9376	0.548304093567251	HSPB1	-0.621454417251168
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/285	108/9376	0.609226770630279	EEF1A1/EIF4A3	-0.723179169896909
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/285	238/9376	0.691139613740233	PAK3/FGF10/GNG4/PDGFRB/FGF7	-0.854530073036103
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/285	63/9376	0.522194374825954	PTGDS	-0.673719272377654
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/285	157/9376	0.628628897083473	ACTG1/TCF7L2/GLI2	-0.830841661370963
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/285	243/9376	0.676918634033644	DDX5/HNRNPA1/SRSF1/EIF4A3/SF3B3	-0.903463387579656
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/285	66/9376	0.498458266879319	CYP1B1	-0.723946450245987
NA	NA	hsa04519	Cadherin signaling	9/285	404/9376	0.732881709223554	VIM/ACTG1/NFKBIA/KRT19/PDGFRB/TCF7L2/PRICKLE2/KRT8/PCDH18	-0.971744109099594
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/285	116/9376	0.567211131276467	GNG4/GRIA3	-0.830427691644579
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/285	69/9376	0.476786168319349	EDNRA	-0.772326869259589
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/285	70/9376	0.469974937343358	CYP1B1	-0.788072442528076
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/285	73/9376	0.450660898822398	SUPT4H1	-0.83424319255931
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/285	73/9376	0.450660898822398	STAT3	-0.83424319255931
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/285	75/9376	0.438643274853801	MAP3K5	-0.8641855073003
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/285	76/9376	0.432871652816251	ACTG1	-0.878919129011802
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/285	76/9376	0.432871652816251	PDGFRB	-0.878919129011802
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/285	78/9376	0.421772379667117	ENO2	-0.907932584470784
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/285	79/9376	0.416433488785254	AP2A2	-0.922220412766913
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/285	133/9376	0.49471046036143	GNG4/GRIA3	-1.03911087725908
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/285	181/9376	0.545274789182902	HLA-DRB5/RAB7A/STAT1	-1.093741505068
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/285	82/9376	0.40119811724433	NME2	-0.964252977578807
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/285	144/9376	0.45692007797271	ID4/STAT3	-1.16278476902339
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/285	89/9376	0.369643209146462	GNG4	-1.05790326071181
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/285	149/9376	0.441587189450135	CXCL8/PDGFRB	-1.21652345333239
NA	NA	hsa04082	Neuroactive ligand signaling	3/285	199/9376	0.495953451467866	GNG4/GRIA3/ADRA2C	-1.27247440904299
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/285	154/9376	0.427249943039417	TPM2/CACNB2	-1.26886430976838
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/285	99/9376	0.33230551125288	IL1R1	-1.18248012483893
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/285	101/9376	0.325725204099357	TCF7L2	-1.2062654622884
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/285	103/9376	0.31940044285471	EIF4A3	-1.22970909171334
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/285	170/9376	0.38703818369453	ACTG1/TCF7L2	-1.42798825767417
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/285	174/9376	0.378140754184311	DNAJA1/MAP3K5	-1.46597932298682
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/285	115/9376	0.286071700991609	GNG4	-1.36388205241681
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/285	115/9376	0.286071700991609	GNG4	-1.36388205241681
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/285	117/9376	0.281181586444744	ACTG1	-1.3852632784867
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/285	125/9376	0.263185964912281	MAP3K5	-1.46832027333471
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/285	250/9376	0.394778947368421	RAB7A/CLN3/AP2A2	-1.71729947834972
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/285	195/9376	0.337417903733693	ACTG1/SLC25A6	-1.65544306136623
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/285	370/9376	0.44457088667615	CGA/CSH1/GRIA3/EDNRA/ADRA2C	-1.93003760089877
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/285	158/9376	0.208216744392627	RPS6	-1.77712814126389
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/285	183/9376	0.179771833956476	RMRP	-1.98396420690527
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/285	191/9376	0.172242123633692	GNG4	-2.04636295157636
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/285	449/9376	0.146540069550268	PRKG1/RGS2	-3.28137434608549