category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	47/641	222/9376	3.096737923571	RPL3/RPL10/RPLP0/RPL6/RPS18/RPS2/RPL10A/RPL7A/RPS4X/RPL5/RPL18A/RPS7/RPL12/RPL13A/RPS5/RPS9/RACK1/RPL29/RPL7/RPL37A/RPS17/RPS26/RPL18/MRPL55/RPS8/RPL8/RPS3/RPL37/RPL23A/RPSA/RPL15/MRPL21/RPS29/MRPS35/RPL17/RPL27A/MRPS30/MRPL14/RPS27/MRPS11/MRPL22/RPS27L/RPL31/MRPL9/MRPL19/MRPS27/RPL35A	8.56442837744718
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	46/641	238/9376	2.8270952686847	CFD/RPL3/RPL10/RPLP0/RPL6/RPS18/C1S/RPS2/RPL10A/RPL7A/RPS4X/RPL5/RPL18A/RPS7/C1R/RPL12/RPL13A/RPS5/RPS9/RPL29/RPL7/RPL37A/RPS17/RPS26/RPL18/RPS8/RPL8/RPS3/RPL37/RPL23A/PRKCB/PIK3R3/RPSA/RPL15/MAPK1/RPS29/IFNAR1/PRKCG/RPL17/RPL27A/RPS27/C9/RPS27L/RPL31/IKBKG/RPL35A	7.73405565479823
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/641	89/9376	3.12264895090186	COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/FN1/LAMB1/LAMA2/CD44/THBS2/ITGB1/CD36/TNXB/COL4A2/ITGB8/COL4A1/GP1BB/HSPG2/ITGAV	5.45027799383848
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/641	204/9376	2.22275243950935	ACTG1/COL1A2/COL1A1/TIMP3/FN1/DDX5/CD44/ITGB1/TWIST2/ROCK2/CD63/CAMK2A/PRKCB/PIK3R3/MAPK1/ARHGEF1/PDPK1/HPSE2/ITPR1/PRKCG/CAV1/MMP2/WNT5A/RPS6KB1/SDC2/PTCH1/ARAF/PTPN6/WNT2/HSPG2/ITGAV	4.78304863554483
NA	NA	hsa04518	Integrin signaling	24/641	154/9376	2.27955507830703	ACTG1/COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/FN1/LAMB1/LAMA2/THBS2/ITGB1/PDGFRB/TNXB/COL4A2/PIK3R3/FERMT2/ITGB8/VCAM1/COL4A1/PARVB/ITGAM/PDGFA/ILK/ITGAV	4.33700561641666
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/641	203/9376	2.08959215511478	ACTG1/COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/FN1/LAMB1/PAK3/LAMA2/THBS2/ITGB1/PDGFRB/ROCK2/TNXB/COL4A2/PRKCB/PIK3R3/ITGB8/ARHGAP5/MAPK1/PDPK1/COL4A1/PRKCG/CAV1/PARVB/PDGFA/ILK/ITGAV	4.25147361578552
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	44/641	362/9376	1.77788503805346	COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/CSH1/FN1/LAMB1/LAMA2/FGF10/THBS2/ITGB1/EFNA2/PDGFRB/GNG4/TNXB/COL4A2/FGF7/PIK3R3/EIF4E/ITGB8/MAGI1/MAGI2/MAPK1/PPP2R2D/PDPK1/CREB3L2/EIF4E2/COL4A1/IFNAR1/RXRA/ANGPT2/CSF1/HSP90B1/LPAR1/BCL2L1/RPS6KB1/CDC37/PDGFA/KITLG/ATF4/IKBKG/PPP2R1A/ITGAV	4.08878359041457
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/641	233/9376	1.94610084832578	COL3A1/FBLN1/VCAN/ACTG1/COL1A2/COL6A1/COL1A1/VIM/COL6A3/COL6A2/FN1/TPM2/LAMA2/FBLN2/THBS2/ITGB1/NID1/COL4A2/ITGB8/SYNPO2/COL4A1/MYH9/PDLIM1/COL5A2/SDC2/COL5A1/ENO2/LMOD1/TMEM43/HSPG2/ITGAV	3.96145047465234
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/641	110/9376	2.39353283222238	TIMP1/LDHA/GAPDH/CAMK2A/PRKCB/PIK3R3/EIF4E/MAPK1/EIF4E2/LTBR/ANGPT2/PRKCG/EP300/RPS6KB1/PDHB/LDHB/ENO2/ARNT	3.98245244262852
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/641	178/9376	2.05437430980385	SFRP2/TCF7L2/APCDD1/ROCK2/PRICKLE2/NOTUM/SFRP4/CAMK2A/MCC/PRKCB/RSPO3/PRICKLE1/FOSL1/PRKCG/CSNK1A1/EP300/ROR2/SMAD4/WNT5A/CSNK2A2/PPP3CC/CTBP1/TCF7/WNT2/APC2	3.84716942421512
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/641	93/9376	2.51649807927801	ACTG1/TCF7L2/ROCK2/RADIL/MAPK1/ACP1/SNAI2/FARP2/EP300/SMAD4/AFDN/CSNK2A2/PTPN6/PTPRF/TCF7/SMURF1	3.98127669727827
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/641	103/9376	2.41418899474426	COL3A1/COL1A2/COL1A1/FN1/LAMB1/LAMA2/IL1R1/COL4A2/HSPB1/RAB7B/PRKCB/PIK3R3/COL4A1/PRKCG/GNA14/C9/ITGAM	3.90930121057577
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/641	56/9376	2.87318921328282	SCUBE2/GAS1/BOC/MOSMO/CSNK1A1/PTCH2/CSNK1D/IQCE/PTCH1/MGRN1/SMURF1	3.80847320028666
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/641	106/9376	2.20787095634769	ZEB1/TCF7L2/PDGFRB/PIK3R3/FOXO1/MAPK1/PDPK1/CREB3L2/HSP90B1/EP300/PDGFA/AR/ARAF/ATF4/TCF7/IKBKG	3.387792502104
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	18/641	128/9376	2.05694227769111	PDE4C/NME4/PDE10A/PDE8B/NME2/NME1/PDE6H/GUK1/NUDT5/GART/ITPA/PRPS2/RRM1/GMPR2/NME7/PRPS1/DGUOK/HDDC2	3.26148618000509
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	36/641	333/9376	1.58131298224902	COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/FN1/TCF7L2/LAMB1/LAMA2/THBS2/ITGB1/PDGFRB/TNXB/COL4A2/PIK3R3/ITGB8/MAGI1/FOXO1/MAPK1/PPP2R2D/CREB3L2/COL4A1/IFNAR1/CSNK1A1/HLA-G/NFX1/EP300/WNT5A/RPS6KB1/ATP6V0A2/TCF7/IKBKG/WNT2/PPP2R1A/APC2/ITGAV	2.92589725597036
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/641	105/9376	2.08959215511478	MAP1LC3B/CALCOCO2/RAB7B/USP8/GABARAPL1/EIF2AK3/BCL2L1/FUNDC1/MFN1/TFE3/CSNK2A2/VCP/ATF4/FKBP8/SMURF1	3.04143489950267
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	47/641	480/9376	1.43224128965159	MT-CO3/MAP1LC3B/TUBB3/CAMK2A/PRKCB/WIPI2/UBE2G2/PSMC6/NDUFB6/ATP5MC1/DCTN6/MAPK1/ITPR1/MT-ATP8/TNFRSF1B/GPX3/PSMD3/TUBB4B/PRKCG/CSNK1A1/CSF1/EIF2AK3/PSMD11/GRIA1/NDUFA11/BCL2L1/DCTN3/ATXN3/WNT5A/VDAC3/PSMB2/MFN1/CSNK2A2/ARAF/TARDBP/PPP3CC/ADRM1/ATP5MC3/VCP/SLC6A3/NDUFB1/ATF4/WDR41/WNT2/APC2/CACNA1B/DNAH12	2.63349610388784
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/641	101/9376	2.0275250613985	COL3A1/COL1A2/COL1A1/FN1/COL4A2/PRKCB/PIK3R3/FOXO1/MAPK1/VCAM1/COL4A1/MMP2/SMAD4/PRKCD	2.81241463487272
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/641	155/9376	1.79300488148558	ACTG1/FCGR3B/C1R/THBS2/TUBB3/ITGB1/CD36/RAB7B/SEC61B/SEC61G/TUBB4B/HLA-G/VAMP3/DYNC1H1/TAP1/ATP6V0A2/ITGAM/SCARB1/ITGAV	2.69672025464884
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/641	103/9376	1.98815564273056	COL3A1/COL1A2/COL6A1/COL1A1/COL6A3/COL6A2/COL15A1/SLC8A2/COL4A2/COL21A1/COL4A1/CELA2A/COL5A2/COL5A1	2.73159957029822
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/641	93/9376	2.04465468941338	FN1/GADD45A/LAMB1/LAMA2/ITGB1/COL4A2/PIK3R3/TRAF5/COL4A1/RXRA/BCL2L1/IKBKG/ITGAV	2.74254179975227
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/641	170/9376	1.72084059832982	ACTG1/TCF7L2/GADD45A/PRKCB/PIK3R3/MAPK1/PRKCG/CSNK1A1/SMARCC2/BCL2L1/SMARCE1/SMAD4/WNT5A/RPS6KB1/ARAF/TXNRD2/TCF7/WNT2/APC2/ACTL6A	2.56927985774091
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/641	75/9376	2.1453146125845	CGA/PRKCB/SLC5A5/ITPR1/GPX3/CREB3L2/PRKCG/HSP90B1/TTF1/ATF4/GSR	2.69757674812854
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/641	205/9376	1.6410943266999	COL3A1/COL1A2/MT-CO3/COL1A1/CD36/GAPDH/GFPT2/CAMK2A/PRKCB/PIK3R3/NDUFB6/ATP5MC1/MT-ATP8/PRKCG/NDUFA11/MMP2/PRKCD/VDAC3/MPC1/PDHB/ATP5MC3/NDUFB1/GSR	2.51404887104495
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/641	67/9376	2.18315598295574	CAMK2A/PRKCB/MAPK1/ITPR1/PRKCG/GRIA1/EP300/ARAF/PPP3CC/ATF4	2.63275889471548
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/641	108/9376	1.89611140001156	EEF1A1/UBE2I/THOC7/SUMO1/AHCTF1/POM121C/UPF3A/TNPO1/NUP107/RANBP17/RNPS1/NUP155/NUP210L/MAGOHB	2.53725470068929
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/641	174/9376	1.68128104434522	UBE2G2/DNAJA2/SEC61B/SEC61G/CKAP4/PRKCSH/PDIA6/UBE2D1/P4HB/EIF2AK3/HSP90B1/NSFL1C/TRAM1/TMEM258/ATXN3/DDOST/VCP/EDEM2/ATF4/RAD23B	2.45721418343081
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/641	31/9376	2.83106033918776	SEC61B/SEC61G/SRPRA/SRP72/GET3/SPCS3	2.7661584161945
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/641	89/9376	1.9721993374117	TUBB3/PDGFRB/PRKG1/GJA1/PRKCB/MAPK1/ITPR1/TUBB4B/PRKCG/LPAR1/CSNK1D/PDGFA	2.49629438351925
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/641	59/9376	2.23125941986832	TCF7L2/GADD45A/PIK3R3/MAPK1/PDPK1/ILK/ARAF/TCF7/APC2	2.56992661738449
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/641	69/9376	2.1198760993918	CAMK2A/PRKCB/MAOB/CREB3L2/PRKCG/GRIA1/ARC/PPP3CC/SLC6A3/ATF4	2.52913995559148
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	26/641	248/9376	1.53349101706004	ACTG1/TXN/TCF7L2/PAK3/TUBB3/ROCK2/ANXA2/GAPDH/RPS3/RAB7B/DYNLL1/CYFIP2/VPS39/DCTN6/MAPK1/DNM2/TUBB4B/DYNC1H1/HSP90B1/STX10/DCTN3/CYTH4/EXOC5/TCF7/IKBKG/TXN2	2.30647278290389
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	31/641	308/9376	1.47221265473996	TGM2/MT-CO3/TUBB3/WIPI2/PSMC6/NDUFB6/ATP5MC1/DCTN6/ITPR1/MT-ATP8/NRF1/GPX3/CREB3L2/PSMD3/TUBB4B/REST/PSMD11/GRIA1/NDUFA11/EP300/DCTN3/VDAC3/PSMB2/POLR2B/POLR2G/ADRM1/ATP5MC3/NDUFB1/POLR2F/CACNA1B/DNAH12	2.28265576226047
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/641	80/9376	2.01123244929797	PDGFRB/PRKCB/PIK3R3/EIF4E/MAPK1/EIF4E2/PRKCG/BCL2L1/RPS6KB1/PDGFA/ARAF	2.46054397653928
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/641	115/9376	1.78069592348911	NACA/PDE4C/PRKCB/MAPK1/ARHGEF1/ITPR1/CREB3L2/MEF2D/MMP16/RXRA/PRKCG/MMP14/ARAF/ATF4	2.28183946985091
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/641	17/9376	3.44168119665963	MTR/SEPSECS/TXNRD2/SEPHS1	2.72949242939572
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/641	232/9376	1.5131529399107	ACTG1/CXCL12/FN1/PAK3/TMSB4X/FGF10/ITGB1/PDGFRB/ROCK2/FGF7/PIK3R3/ITGB8/CYFIP2/MAPK1/ARHGEF1/MYH9/LPAR1/C9/ITGAM/PDGFA/BDKRB1/ARAF/APC2/ITGAV	2.14390680817903
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	35/641	368/9376	1.39116869022587	ACTG1/MT-CO3/MAP1LC3B/TUBB3/WIPI2/PSMC6/NDUFB6/ATP5MC1/DCTN6/MT-ATP8/TNFRSF1B/GPX3/PSMD3/POM121C/TUBB4B/NUP107/HNRNPA1/EIF2AK3/PSMD11/GRIA1/NDUFA11/BCL2L1/DCTN3/PSMB2/NUP155/TARDBP/PPP3CC/ADRM1/ATP5MC3/VCP/NUP210L/NDUFB1/ATF4/WDR41/DNAH12	2.07375289233034
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/641	85/9376	1.8929246581628	NME4/NME2/NME1/GUK1/ITPA/DUT/RRM1/GMPR2/NME7/DGUOK/HDDC2	2.24014560390238
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/641	86/9376	1.87091390632369	ACTG1/TCF7L2/LAMA2/CACNB2/ITGB1/CACNG7/SLC8A2/GJA1/ITGB8/TCF7/ITGAV	2.1978588208129
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/641	212/9376	1.51791128248904	ACTG1/FGF10/ITGB1/EFNA2/PDGFRB/FGF7/PRKCB/PIK3R3/MAGI1/MAGI2/MAPK1/RALB/ANGPT2/PRKCG/MAGI3/CSF1/FARP2/LPAR1/AFDN/ITGAM/PDGFA/KITLG	2.06616005246414
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/641	224/9376	1.50189436148875	IL1R1/PIK3R3/MAPK1/CREB3L2/VAC14/LTBR/IL15/FOSL1/ANAPC5/HLA-G/BCL2L1/EP300/SMAD4/VDAC3/CRTC3/CRTC1/PPP3CC/RANBP1/ANAPC11/ATF4/FDPS/IKBKG/NFYB	2.05949868213233
NA	NA	hsa04517	IgSF CAM signaling	29/641	299/9376	1.4186863126699	ACTG1/MYL6/PAK3/TUBB3/NPHS1/ITGB1/NLGN1/TJP2/PRKCB/DYNLL1/SLAMF1/PIK3R3/MAGI1/FOXO1/MAGI2/MAPK1/PDPK1/KCNQ3/MYH9/TUBB4B/DOK2/PRKCG/ABL1/AFDN/ITGAM/CD28/PTPN6/PTPRF/JAM2	1.99313349808387
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	27/641	275/9376	1.43611969933343	MT-CO3/TUBB3/PIK3R3/PSMC6/NDUFB6/ATP5MC1/MAPK1/ITPR1/MT-ATP8/CREB3L2/PSMD3/TUBB4B/CAV1/EIF2AK3/PSMD11/NDUFA11/PRKCD/VDAC3/C9/PSMB2/CSNK2A2/PPP3CC/ADRM1/ATP5MC3/NDUFB1/ATF4/CACNA1B	1.98843176364152
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/641	77/9376	1.89962923192252	GADD45A/PIK3R3/RALBP1/MAPK1/RALB/BCL2L1/SMAD4/RPS6KB1/ARAF/IKBKG	2.14720740231089
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/641	134/9376	1.6373669872168	MYL6/PRKG1/ROCK2/PRKCB/MAPK1/ARHGEF1/ITPR1/CALD1/MYH9/PRKCG/EDNRA/PRKCD/ARAF/RAMP1/PLA2G6	2.0129926102417
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/641	169/9376	1.5579207783696	MAP1LC3B/CALCOCO2/RAB7B/PIK3R3/WIPI2/VPS39/MAPK1/PDPK1/ITPR1/GABARAPL1/EIF2AK3/SNAP29/BCL2L1/PRKCD/RPS6KB1/IGBP1/WDR41/ATG4B	1.98262242901967
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/641	243/9376	1.44465630477071	DDX5/HNRNPC/PRPF38A/THOC7/ZMAT2/CDC5L/LSM7/SNRNP70/HNRNPA1/PRPF6/SRSF1/PLRG1/ISY1/SF3A3/DDX42/EFTUD2/SYF2/SNRNP200/SNRPC/SRSF8/MAGOHB/PPIH/SNW1/TCERG1	1.90240974013189
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	26/641	268/9376	1.41905138892123	MT-CO3/TXN/TUBB3/CAMK2A/UBE2G2/PSMC6/MAOB/NDUFB6/ATP5MC1/ITPR1/MT-ATP8/PSMD3/TUBB4B/EIF2AK3/PSMD11/NDUFA11/BCL2L1/VDAC3/PSMB2/MFN1/ADRM1/ATP5MC3/SLC6A3/NDUFB1/ATF4/TXN2	1.88541244234021
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/641	184/9376	1.51041172081666	SEMA5A/CXCL12/PAK3/TRPC4/ITGB1/EFNA2/ROCK2/CAMK2A/PIK3R3/BOC/MAPK1/PDPK1/RGS3/WNT5A/ABL1/PTCH1/ILK/PPP3CC/SEMA3C	1.89412109418347
Organismal Systems	Immune system	hsa04611	Platelet activation	14/641	126/9376	1.62523834286705	COL3A1/ACTG1/COL1A2/COL1A1/ITGB1/PRKG1/ROCK2/STIM1/PIK3R3/MAPK1/ARHGEF1/ITPR1/RASGRP1/GP1BB	1.91400561651483
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/641	150/9376	1.56022880915237	TCF7L2/GADD45A/FGF10/FGF7/PIK3R3/MAPK1/ABCB1/RXRA/CSNK1A1/SMAD4/WNT5A/RPS6KB1/ARAF/TCF7/WNT2/APC2	1.87364600267842
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/641	60/9376	1.95028601144046	PRKG1/PRKCB/MAPK1/ITPR1/PRKCG/GRIA1/ARAF/PPP2R1A	2.00031513006472
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/641	30/9376	2.43785751430057	MTR/GART/ABCC1/IKBKG/DHFR	2.13671593428023
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/641	116/9376	1.63924901823659	ACTG1/CXCL12/ITGB1/ROCK2/PRKCB/PIK3R3/ARHGAP5/VCAM1/PRKCG/MMP2/AFDN/ITGAM/JAM2	1.87662185282967
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/641	250/9376	1.40420592823713	SNX32/EHD1/SNF8/ZFYVE9/DNM2/VPS4A/ACAP1/CHMP4A/ARF3/WASHC2C/VPS4B/WASHC3/USP8/CAV1/HLA-G/SPG21/ARFGEF2/CYTH4/MVB12A/CHMP3/RAB11FIP2/SMURF1/RAB4A/EPS15L1	1.75475160845379
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/641	63/9376	1.85741524899091	CUL4A/RPA2/RFC2/POLR2B/POLR2G/GTF2H3/POLR2F/RAD23B	1.84969394396184
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/641	63/9376	1.85741524899091	TCF7L2/GADD45A/PTCH2/WNT5A/PTCH1/TCF7/WNT2/APC2	1.84969394396184
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/641	144/9376	1.52366094643786	RORA/PRKCB/PIK3R3/WIPI2/PSMC6/ITPR1/PSMD3/PRKCG/NOP56/PSMD11/GRIA1/ATXN3/VDAC3/PSMB2/ADRM1	1.71540524152459
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/641	133/9376	1.53969948271615	GNG4/CAMK2A/PRKCB/MAOB/PPP2R2D/ITPR1/CREB3L2/PRKCG/GRIA1/PPP3CC/SLC6A3/ATF4/PPP2R1A/CACNA1B	1.69806591315887
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/641	157/9376	1.49066446734302	PBX1/ABCA1/CD36/CAMK2A/RAB7B/PROS1/VPS39/MAPK1/DNMT3A/LIPA/RXRA/PTPN6/ARNT/XKR6/PLA2G6/ITGAV	1.67948343871948
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/641	110/9376	1.59568855481492	THSD4/ID4/NBL1/FMOD/SMAD5/MAPK1/ZFYVE9/EP300/SMAD4/RPS6KB1/SMURF1/PPP2R1A	1.70236487100575
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/641	87/9376	1.68128104434522	TCF7L2/GADD45A/PIK3R3/MAPK1/RALB/SMAD4/RPS6KB1/ARAF/TCF7/APC2	1.72935697016315
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/641	76/9376	1.73216191805567	GADD45A/PDGFRB/CAMK2A/PRKCB/PIK3R3/MAPK1/PRKCG/PDGFA/ARAF	1.73602372603536
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/641	88/9376	1.66217557793221	CFD/C1S/C1R/PROCR/SERPINE2/TFPI/PROS1/C9/ITGAM/BDKRB1	1.69058336100228
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/641	44/9376	1.99461069351865	TAF11/TAF9/GTF2E2/GTF2F1/TAF10/GTF2H3	1.79132874802155
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/641	77/9376	1.70966630873027	GADD45A/PIK3R3/MAPK1/BCL2L1/SMAD4/ABL1/ARAF/CTBP1/IKBKG	1.69380973539498
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/641	101/9376	1.59305540538453	TCF7L2/CAMK2A/PRKCB/MAPK1/CREB3L2/PRKCG/EP300/WNT5A/KITLG/TCF7/WNT2	1.62323797642827
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/641	137/9376	1.49474475329378	ACTG1/GADD45A/SEPTIN4/PIK3R3/MAPK1/PDPK1/ITPR1/EIF2AK3/CASP2/BCL2L1/CASP10/ATF4/IKBKG/PTPN13	1.58020050258209
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/641	200/9376	1.38957878315133	ACTG1/PAK3/TUBB3/ITGB1/ROCK2/IL1R1/GAPDH/RPS3/CYFIP2/MAPK1/ARHGEF1/MYO10/MYH9/TUBB4B/LPAR1/CYTH4/ABL1/PTPN6/IKBKG	1.50857459735174
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/641	238/9376	1.35208904154485	PAK3/FGF10/EFNA2/PDGFRB/GNG4/FGF7/PRKCB/PIK3R3/RALBP1/MAPK1/RALB/RASGRP1/ANGPT2/PRKCG/CSF1/BCL2L1/ABL1/AFDN/PDGFA/KITLG/IKBKG/PLA2G6	1.49038547109412
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/641	68/9376	1.72084059832982	TCF7L2/PIK3R3/MAPK1/RPS6KB1/ITGAM/ARAF/TCF7/IKBKG	1.6160273471311
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/641	93/9376	1.57281129954876	CGA/CAMK2A/PRKCB/MAP3K4/MAPK1/ITPR1/MMP14/MMP2/PRKCD/ATF4	1.50380690222627
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/641	105/9376	1.5323675804175	CXCL12/GADD45A/IL1R1/PRKCB/UBE2I/TRAF5/VCAM1/LTBR/BCL2L1/CSNK2A2/IKBKG	1.48602514330238
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/641	37/9376	1.97664122781127	UAP1/GFPT2/PMM2/TGDS/GNPNAT1	1.61238565698212
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/641	37/9376	1.97664122781127	TCF7L2/GADD45A/MAPK1/RXRA/TCF7	1.61238565698212
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/641	142/9376	1.44211289578344	ACTG1/TXN/IL1R1/PIK3R3/SUMO1/VCAM1/CAV1/HSP90B1/MMP2/SDC2/PDGFA/IKBKG/TXN2/ITGAV	1.43802229114245
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/641	59/9376	1.73542399323092	NME4/NME2/NME1/DUT/RRM1/NME7/HDDC2	1.5350020188836
NA	NA	hsa03272	Virion - Hepatitis viruses	6/641	48/9376	1.82839313572543	CD63/VPS4A/CHMP4A/VPS4B/SCARB1/HSPG2	1.55864079789942
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/641	155/9376	1.41553016959388	TCF7L2/PBX1/CAMK2A/MAPK1/PDE8B/ITPR1/CREB3L2/USP8/WNT5A/SCARB1/ARNT/ATF4/TCF7/WNT2/APC2	1.41306649041335
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/641	119/9376	1.47500622713984	PIK3R3/MAPK1/TRAF5/VCAM1/TNFRSF1B/CREB3L2/IL15/CSF1/MMP14/CASP10/ATF4/IKBKG	1.41260536133528
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/641	38/9376	1.92462435339519	PRKCB/PIK3R3/MAPK1/PDPK1/PRKCG	1.54708220158379
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/641	73/9376	1.60297480392366	GADD45A/FGF10/PDGFRB/FGF7/PIK3R3/MAPK1/PDGFA/ARAF	1.40098112062217
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/641	73/9376	1.60297480392366	GADD45A/PRKCB/PIK3R3/MAPK1/PDPK1/RXRA/PRKCG/ARAF	1.40098112062217
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/641	109/9376	1.47613390774163	CD36/GFPT2/PRKCB/PIK3R3/FOXO1/PDPK1/CREB3L2/MLXIP/PRKCD/RPS6KB1/PTPRF	1.35442816578783
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/641	98/9376	1.49256582508198	FCGR3B/PRKCB/PIK3R3/MAPK1/DNM2/MYO10/PRKCG/PRKCD/RPS6KB1/PLA2G6	1.32780203108391
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/641	86/9376	1.53074774153757	PAK3/CAMK2A/PRKCB/PIK3R3/MAPK1/PRKCG/RPS6KB1/ABL1/ARAF	1.33940748551018
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/641	51/9376	1.72084059832982	ACTG1/TJP2/SLC12A2/SEC61B/SEC61G/ATP6V0A2	1.39824445132853
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/641	148/9376	1.38364885946789	TCF7L2/GADD45A/DLL3/FGF10/FGF7/PIK3R3/MAPK1/CSNK1A1/WNT5A/RPS6KB1/ARAF/TCF7/WNT2/APC2	1.2743659956498
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/641	99/9376	1.47748940260641	PDGFRB/PRKCB/PIK3R3/MAPK1/PDPK1/PRKCG/CHKB/SLC22A3/RPS6KB1/PDGFA	1.29378095722375
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/641	52/9376	1.6877475099004	ABCA1/CD36/LIPA/MYLIP/VDAC3/SCARB1	1.34714010141399
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/641	253/9376	1.27192565963508	ACTG1/MAP1LC3B/CD44/ITGB1/CALCOCO2/ROCK2/IL1R1/PIK3R3/WIPI2/FOXO1/MAPK1/TRAF5/ITPR1/SEPTIN11/CAPNS1/UBE2D1/BCL2L1/CYTH4/PRKCD/RPS6KB1/ILK/IKBKG	1.18774937939411
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/641	125/9376	1.40420592823713	SGMS2/ROCK2/PRKCB/PIK3R3/MAPK1/PPP2R2D/PDPK1/PRKCG/ABCC1/S1PR3/CERS2/PPP2R1A	1.2323853956463
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/641	20/9376	2.19407176287051	UAP1/CYB5R3/TGDS	1.44804986654388
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	32/641	388/9376	1.20636248130338	MT-CO3/TUBB3/RTN4/GAPDH/PIK3R3/WIPI2/PSMC6/NDUFB6/ATP5MC1/MAPK1/ITPR1/MT-ATP8/PSMD3/TUBB4B/CSNK1A1/CSF1/EIF2AK3/PSMD11/NDUFA11/WNT5A/VDAC3/PSMB2/CSNK2A2/ARAF/PPP3CC/ADRM1/ATP5MC3/NDUFB1/ATF4/IKBKG/WNT2/APC2	1.12460049521726
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/641	65/9376	1.57523100924037	CGA/TRPC4/PRKCB/PIK3R3/MAPK1/ITPR1/PRKCG	1.2606194484802
NA	NA	hsa04981	Folate transport and metabolism	4/641	31/9376	1.88737355945851	MTR/SLC22A6/ABCC1/DHFR	1.34054339295747
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/641	90/9376	1.46271450858034	PIK3R3/EIF4E/FOXO1/CREB3L2/EIF4E2/EHMT1/RPS6KB1/SESN2/ATF4	1.19482205489023
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/641	90/9376	1.46271450858034	PIK3R3/MAPK1/RASGRP1/RPS6KB1/CD28/CSNK2A2/PPP3CC/PTPN6/IKBKG	1.19482205489023
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/641	115/9376	1.39911822559859	GNG4/CAMK2A/PRKCB/PIK3R3/MAPK1/ITPR1/KCNQ3/CREB3L2/PRKCG/ATF4/CACNA1B	1.1665537028008
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/641	78/9376	1.50022000880035	ACTG1/FN1/ITGB1/PIK3R3/DNM2/SEPTIN11/CAV1/ILK	1.20170201181738
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/641	21/9376	2.08959215511478	CHST12/CHST7/DSEL	1.35405067333634
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/641	21/9376	2.08959215511478	PPCS/AASDHPPT/CSAD	1.35405067333634
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/641	32/9376	1.82839313572543	LDHA/ACSS3/SUCLG1/LDHB	1.27153483945352
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/641	32/9376	1.82839313572543	WIPI2/GABARAPL1/IGBP1/ATG4B	1.27153483945352
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/641	44/9376	1.66217557793221	DYNLL1/DCTN6/CREB3L2/NSF/DYNC1H1	1.19260144367783
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/641	22/9376	1.99461069351865	MAOB/CARNMT1/CNDP1	1.26517027637336
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/641	45/9376	1.62523834286705	ABCA1/ABCB1/ABCB4/TAP1/ABCC1	1.13886163704129
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/641	158/9376	1.29607614684334	PRKCB/PIK3R3/EIF4E/MAPK1/PDPK1/EIF4E2/PRKCG/CAB39L/TBC1D7/WNT5A/RPS6KB1/SESN2/CLIP1/WNT2	1.01670933261381
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/641	94/9376	1.40047133800246	MAPK1/TRAF5/FOSL1/ANAPC5/MAPK6/HSP90B1/SRSF1/S100A9/IKBKG	1.05705547954936
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/641	107/9376	1.36702290521527	LDHA/CAMK2A/FOXO1/ITPR1/CREB3L2/EP300/PDHB/PPP3CC/LDHB/ATF4	1.03431259851535
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/641	34/9376	1.72084059832982	POLR2B/POLR2G/POLR1A/POLR2F	1.14062257765353
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/641	34/9376	1.72084059832982	RORA/NFIL3/RORB/CSNK1D	1.14062257765353
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/641	70/9376	1.46271450858034	PAK3/PIK3R3/MAPK1/EP300/TFE3/ARAF/ARNT	1.05260108024558
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/641	46/9376	1.58990707454385	PSMC6/PSMD3/PSMD11/PSMB2/ADRM1	1.08643787347353
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/641	23/9376	1.90788848945262	FNTA/HMGCR/FDPS	1.18087562744668
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/641	83/9376	1.40984530947503	AUTS2/AEBP2/PHC3/DCAF7/EZH1/FOXK1/UBE2D1/EP300	1.01593107600235
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/641	227/9376	1.224298487358	CXCL12/ROCK2/GNG4/IL1R1/PRKCB/PIK3R3/MAPK1/ARHGEF1/TRAF5/ITPR1/CREB3L2/PRKCG/HLA-G/TAP1/RPS6KB1/PPP3CC/ATF4/IKBKG/ITGAV	0.926692520702231
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/641	122/9376	1.31884095035933	EEF2/CD36/PIK3R3/FOXO1/PPP2R2D/PDPK1/CREB3L2/CAB39L/RPS6KB1/HMGCR/PPP2R1A	0.960223788639955
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/641	122/9376	1.31884095035933	PAK3/PIK3R3/MAPK1/PPP2R2D/PDPK1/RASGRP1/CD28/PPP3CC/PTPN6/IKBKG/PPP2R1A	0.960223788639955
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/641	163/9376	1.25631920982361	PRKCB/PIK3R3/MAPK1/CREB3L2/IFNAR1/PRKCG/CASP10/EP300/SMAD4/VDAC3/ARAF/ATF4/IKBKG/HSPG2	0.894247264857864
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/641	60/9376	1.46271450858034	HSPB1/PRKCB/PIK3R3/MAPK1/PRKCG/PPP3CC	0.973996061470714
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/641	73/9376	1.40260295343321	PPIA/VPS4A/SUPT5H/CHMP4A/VPS4B/EP300/APOBEC3D	0.935427373078191
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/641	99/9376	1.32974046234577	IL1R1/CAMK2A/PRKCB/PIK3R3/ITPR1/PRKCG/PRKCD/BDKRB1/PLA2G6	0.893447956500016
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/641	99/9376	1.32974046234577	ACTG1/TPM2/LAMA2/CACNB2/ITGB1/CACNG7/SLC8A2/ITGB8/ITGAV	0.893447956500016
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/641	300/9376	1.17017160686427	GADD45A/FGF10/CACNB2/CACNG7/EFNA2/PDGFRB/IL1R1/FGF7/HSPB1/PRKCB/MAP3K4/MAPK1/RASGRP1/ANGPT2/PRKCG/CSF1/MAP3K13/PDGFA/ARAF/PPP3CC/KITLG/ATF4/IKBKG/CACNA1B	0.811490951872514
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/641	37/9376	1.58131298224902	PRKCB/HBB/VCAM1/PRKCG	0.959718562052089
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/641	75/9376	1.36520020800832	GAPDH/MTR/ASL/PRPS2/TALDO1/ENO2/PRPS1	0.860161547499914
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/641	75/9376	1.36520020800832	GADD45A/SHISA5/CCNG1/CCNG2/PPM1D/BCL2L1/SESN2	0.860161547499914
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/641	194/9376	1.20636248130338	ACTG1/MYL6/TPM2/TUBB3/DYNLL1/DCTN6/MYO9A/MYO10/MYH9/TUBB4B/KIF13A/DYNC1H1/DCTN3/KIFAP3/MYO15B/DNAH12	0.786767044518547
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/641	50/9376	1.46271450858034	THBS2/CD36/HBB/VCAM1/SDC2	0.888655866162234
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	19/641	235/9376	1.18262024097985	ACTG1/MT-CO3/PRKG1/NDUFB6/ATP5MC1/MT-ATP8/CREB3L2/SMARCC2/COA4/NDUFA11/SMARCE1/PNPLA2/RPS6KB1/ATP5MC3/NDUFB1/NDUFAF8/COX11/COA6/ACTL6A	0.768014087899014
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/641	38/9376	1.53969948271615	UAP1/GFPT2/PMM2/GNPNAT1	0.90302560261169
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/641	26/9376	1.6877475099004	BTD/ABCC1/SCARB1	0.95124654738799
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/641	89/9376	1.31479955827447	GNG4/PRKCB/GABRA2/NSF/PRKCG/GABARAPL1/PLCL1/CACNA1B	0.808303749051119
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/641	170/9376	1.20458841883087	ACTG1/MYL6/ITGB1/ROCK2/TJP2/MAGI1/PPP2R2D/MYH9/ARHGEF18/AFDN/WHAMM/RAB13/JAM2/PPP2R1A	0.729211013984414
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/641	130/9376	1.23768150726029	COL3A1/COL1A2/COL1A1/GNG4/COL4A2/PIK3R3/MAPK1/CREB3L2/COL4A1/MMP2/ATF4	0.739219343571367
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/641	39/9376	1.50022000880035	CHDH/MTR/GART/DHFR	0.847955149507918
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	10/641	117/9376	1.25018334066696	ACTG1/BCL7C/SMARCC2/BRD9/MBD2/EP400/INO80/SMARCE1/MTA1/ACTL6A	0.737653613872697
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/641	144/9376	1.21892875715029	ID4/SMARCAD1/PIK3R3/SMAD5/MAPK1/REST/SMAD4/WNT5A/SETDB1/TCF7/WNT2/APC2	0.717165448542057
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/641	27/9376	1.62523834286705	HSD17B12/FADS1/ELOVL7	0.881308794338498
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/641	91/9376	1.28590286468602	PDE4C/GNG4/PDE10A/PRKCB/PDE8B/GABRA2/PRKCG/CACNA1B	0.742388861600073
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/641	78/9376	1.31269250770031	FCGR3B/EEF1A1/ITGB1/PRKCB/MAPK1/ITGAM/PTPN6	0.751195891753415
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/641	65/9376	1.35019800792032	PBX1/PDE8B/ITPR1/CREB3L2/SCARB1/ATF4	0.76745935547939
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/641	105/9376	1.25375529306887	ACTG1/TPM2/LAMA2/CACNB2/ITGB1/CACNG7/SLC8A2/ITGB8/ITGAV	0.708320265202238
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	18/641	227/9376	1.15986172486547	MT-CO3/CYP1B1/PIK3R3/NDUFB6/ATP5MC1/MAPK1/PDPK1/MT-ATP8/ACP1/NDUFA11/PRKCD/ABL1/VDAC3/ARAF/ATP5MC3/ARNT/NDUFB1/IKBKG	0.660471082637945
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/641	214/9376	1.16196946943298	PAK3/GNG4/PRKCB/PIK3R3/MAPK1/TRAF5/ITPR1/TNFRSF1B/CUL4A/PRKCG/HLA-G/TAP1/BCL2L1/RPS6KB1/APOBEC3D/PPP3CC/IKBKG	0.649274132760378
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/641	53/9376	1.37991934771731	SLC8A2/PRKCB/DNM2/PRKCG/ATP2B4	0.751336871096992
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/641	160/9376	1.18845553822153	VCAN/ITGB1/NRXN2/NLGN1/ITGB8/VCAM1/HLA-G/SDC2/ITGAM/CD28/PTPRF/JAM2/ITGAV	0.651299674841464
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/641	16/9376	1.82839313572543	MAOB/MIF	0.898342107944087
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	17/641	216/9376	1.15121049286416	ABCA1/CD36/ROCK2/CAMK2A/PIK3R3/MAPK1/ARHGEF1/PDPK1/VCAM1/ITPR1/RXRA/EIF2AK3/HSP90B1/BCL2L1/PPP3CC/ATF4/IKBKG	0.609037825239517
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/641	54/9376	1.35436528572254	LDHA/DNMT1/MTR/DNMT3A/LDHB	0.707418967291637
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/641	122/9376	1.19894631850848	ACTG1/PRKCB/PIK3R3/FOXO1/MAPK1/PDPK1/RXRA/PRKCG/EP300/ITGAV	0.599148219445753
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/641	17/9376	1.72084059832982	GGT5/CSAD	0.805809111621129
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/641	17/9376	1.72084059832982	CA8/CA5B	0.805809111621129
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/641	82/9376	1.24865872683688	NME4/NME2/NME1/ITPA/DUT/RRM1/NME7	0.612621869243684
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/641	56/9376	1.30599509694673	MGAT4C/ALG3/TMEM258/DDOST/SRD5A3	0.622133694704769
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/641	56/9376	1.30599509694673	EEF1A1/EEF1G/RAB1B/ITGAM/VCP	0.622133694704769
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/641	138/9376	1.16593185466549	PIK3R3/EIF4E/FOXO1/MAPK1/PDPK1/PRKAR1A/EIF4E2/INPP5A/RPS6KB1/ARAF/PTPRF	0.531941079127434
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/641	97/9376	1.20636248130338	PRKG1/GNG4/CAMK2A/PRKCB/MAPK1/ITPR1/PRKCG/GRIA1	0.553412824790141
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/641	70/9376	1.25375529306887	ACTG1/LAMA2/CAV1/HLA-G/ABL1/CD28	0.577252475661121
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/641	166/9376	1.14549931394846	PRKG1/ROCK2/SLC8A2/ADRA2C/MAPK1/ITPR1/CREB3L2/MEF2D/EDNRA/VDAC3/PPP3CC/ATF4/ATP2B4	0.512351925606032
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/641	18/9376	1.62523834286705	MTR/MTRR	0.719239505519731
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/641	44/9376	1.32974046234577	MGAT4C/ALG3/TMEM258/DDOST	0.59387413933411
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/641	98/9376	1.19405266006559	CAMK2A/PRKCB/ITPR1/CREB3L2/PRKCG/SCARB1/ATF4/ATP2B4	0.523104736568833
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/641	31/9376	1.41553016959388	PRPS2/TALDO1/PRPS1	0.627735881338958
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/641	71/9376	1.23609676781437	LDHA/PDGFRB/PIK3R3/MAPK1/PDHB/LDHB	0.540933932693546
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/641	154/9376	1.13977753915351	NME4/PPCS/RDH12/PMM2/LIAS/NME2/NME1/PTS/VKORC1L1/UROD/NME7/DHFR	0.473770908837915
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/641	154/9376	1.13977753915351	ACTG1/MYL6/EEF2/CACNB2/CACNG7/ROCK2/CAMK2A/PRKCB/MAPK1/ITPR1/PRKCG/PPP3CC	0.473770908837915
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/641	100/9376	1.17017160686427	CD44/CD36/IL1R1/CSF1/GP1BB/IL11/ITGAM/KITLG	0.463436171840311
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/641	19/9376	1.53969948271615	HPSE2/NAGLU	0.637886903697562
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/641	19/9376	1.53969948271615	LIAS/PDHB	0.637886903697562
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/641	59/9376	1.23958856659351	GGT5/GPX3/RRM1/LANCL1/GSR	0.50007742038271
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/641	33/9376	1.32974046234577	VAMP3/SNAP29/GOSR1	0.514007240132512
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/641	187/9376	1.09508038075534	MAP1LC3B/TXN/MAPK1/TRAF5/ITPR1/ERBIN/IFNAR1/GABARAPL1/BCL2L1/PRKCD/VDAC3/MFN1/IKBKG/TXN2	0.355763007654923
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/641	47/9376	1.24486341155774	PIK3R3/MAPK1/PRKCD/CACNA1B	0.455867337752486
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/641	75/9376	1.17017160686427	REV3L/PIK3R3/MAPK1/PDPK1/BCL2L1/TOP2B	0.400807747342758
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/641	217/9376	1.07849917683343	DLL3/FGF10/CYP1B1/FGF7/PRKCB/PIK3R3/MAPK1/CREB3L2/RXRA/PRKCG/HSP90B1/RPS6KB1/AR/ARNT/ATF4/CACNA1B	0.316923277319096
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/641	62/9376	1.17960847466157	DLL3/DTX4/EP300/CTBP1/SNW1	0.384359616026228
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/641	133/9376	1.09978534479725	GADD45A/PIK3R3/FOXO1/MAPK1/PDPK1/CCNG2/GABARAPL1/EP300/SMAD4/ARAF	0.313956373981059
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/641	133/9376	1.09978534479725	FCGR3B/PRKCB/PIK3R3/MAPK1/IFNAR1/PRKCG/HLA-G/ARAF/PPP3CC/PTPN6	0.313956373981059
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/641	205/9376	1.07027890871732	PIK3R3/MAPK1/TRAF5/CREB3L2/VAC14/LTBR/HLA-G/EP300/VDAC3/GTF2E2/GTF2H3/RANBP1/ATF4/IKBKG/SNW1	0.275598463066369
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/641	63/9376	1.16088453061932	DOT1L/EZH1/EHMT1/COLGALT1/SETDB1	0.347074701918269
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/641	49/9376	1.19405266006559	MAOB/CREB3L2/SLC6A3/ATF4	0.368918004069301
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/641	149/9376	1.07985634861636	GNG4/PRKCB/NDUFB6/MAPK1/ITPR1/GABRA2/PRKCG/GRIA1/NDUFA11/NDUFB1/CACNA1B	0.266167803486172
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/641	50/9376	1.17017160686427	PRODH2/MAOB/CNDP1/SAT2	0.326819224143549
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/641	50/9376	1.17017160686427	CXCL12/LTBR/IL15/CD28	0.326819224143549
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/641	36/9376	1.21892875715029	RPA2/RFC2/POLA2	0.356503519896441
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/641	323/9376	1.04156141477857	VIM/TIMP3/ZEB1/CD44/CYP1B1/EFNA2/PDGFRB/TNXB/PRKCB/PIK3R3/DNMT1/UBE2I/MAPK1/CCNG1/DNMT3A/MMP16/ABCB1/PRKCG/EP300/ABCC1/ABL1/PDGFA/APC2	0.20591051371182
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/641	93/9376	1.10096790968413	LYZ/PRKG1/SLC12A2/PRKCB/ITPR1/PRKCG/ATP2B4	0.265072004700263
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/641	79/9376	1.11092241158001	CPLX1/DNM2/NSF/ATP6V0A2/SLC6A3/CACNA1B	0.268191266713528
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/641	122/9376	1.07905168665763	CSH1/PRKCB/PIK3R3/MAPK1/ITPR1/CREB3L2/PRKCG/EP300/ATF4	0.238072650251552
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/641	37/9376	1.18598473668676	GFPT2/ASL/NIT2	0.307051467122055
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/641	37/9376	1.18598473668676	AOX1/MAOB/MIF	0.307051467122055
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/641	138/9376	1.0599380496959	CAMK2A/MAPK1/SLK/SMC3/ITPR1/ANAPC5/AR/PPP3CC/ANAPC11/PPP2R1A	0.192148221933074
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/641	23/9376	1.27192565963508	LARGE1/FKTN	0.353689233502708
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/641	23/9376	1.27192565963508	RPA2/RFC2	0.353689233502708
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/641	168/9376	1.04479607755739	CSH1/PDGFRB/AOX1/PIK3R3/IFNAR1/IL15/BCL2L1/EP300/SOCS5/IL11/PDGFA/PTPN6	0.1587066672269
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/641	139/9376	1.05231259610097	KRT19/PIK3R3/MAPK1/ITPR1/CREB3L2/FKBP4/HSP90B1/MMP2/PRKCD/ATF4	0.16831832465521
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/641	154/9376	1.04479607755739	TPM2/CACNB2/CACNG7/SLC8A2/CAMK2A/MAPK1/PPP2R2D/CREB3L2/ATF4/ATP2B4/PPP2R1A	0.151834683206353
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/641	38/9376	1.15477461203711	AOX1/NNMT/NMRK2	0.258969003639592
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/641	67/9376	1.09157799147787	LDHA/GAPDH/PDHB/LDHB/ENO2	0.203779362228485
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/641	68/9376	1.07552537395613	ALDH1A3/AOX1/RDH12/ALDH1A2/RDH10	0.169317696586747
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/641	142/9376	1.03008063984531	HERC4/UBE2G2/UBE2I/ANAPC5/CUL4A/UBA2/UBE2D1/ANAPC11/MGRN1/SMURF1	0.09784068965628
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/641	142/9376	1.03008063984531	FCGR3B/IL1R1/PIK3R3/MAPK1/ITPR1/IFNAR1/FOSL1/CSF1/PPP3CC/IKBKG	0.09784068965628
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/641	157/9376	1.02483182129833	ACTG1/TCF7L2/PPP2R2D/SNAI2/CSNK1D/SMAD4/WNT5A/TCF7/WNT2/PPP2R1A/APC2	0.0849962355122617
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/641	115/9376	1.01754052770806	GNG4/PRKCB/MAOB/MAPK1/ITPR1/PRKCG/ARAF/CACNA1B	0.0512679357507033
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/641	41/9376	1.07027890871732	BABAM1/RAD50/RPA2	0.122163924160554
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/641	41/9376	1.07027890871732	GABRA2/GRIA1/CACNA1B	0.122163924160554
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/641	41/9376	1.07027890871732	MAPK1/MMP2/ARAF	0.122163924160554
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/641	205/9376	0.998926981469503	VIM/GADD45A/CD44/PIK3R3/PSMC6/TRAF5/PSMD3/IFNAR1/HLA-G/TAP1/PSMD11/ADRM1/IKBKG/SNW1	-0.00420783793095378
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/641	116/9376	1.00876862660713	GNG4/PRKCB/MAPK1/ITPR1/PRKCG/GRIK5/GRIA1/PPP3CC	0.0257417623505204
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/641	102/9376	1.00382368235906	SLC12A2/PRKCB/RAB27B/ITPR1/PRKCG/CELA2A/ATP2B4	0.0105179607493614
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/641	57/9376	1.02646632181077	HSD17B12/FADS1/CBR4/ELOVL7	0.0542912147731259
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/641	42/9376	1.04479607755739	CYP1B1/AOX1/MAOB	0.0788159170548316
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/641	42/9376	1.04479607755739	MAP1LC3B/SAT2/VDAC3	0.0788159170548316
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/641	43/9376	1.02049849435838	ABCA1/CD36/SCARB1	0.0364946124350197
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/641	12/9376	1.21892875715029	VKORC1L1	0.20556346538762
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/641	12/9376	1.21892875715029	SLAMF1	0.20556346538762
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/641	254/9376	0.978982151412041	FGF10/PDGFRB/SLC8A2/FGF7/CAMK2A/STIM1/PRKCB/ITPR1/PRKCG/EDNRA/GNA14/VDAC3/PDGFA/BDKRB1/PPP3CC/ATP2B4/CACNA1B	-0.0919905640361155
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/641	28/9376	1.04479607755739	HSD17B12/ELOVL7	0.0643047197723439
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/641	28/9376	1.04479607755739	PTS/DHFR	0.0643047197723439
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/641	59/9376	0.991670853274809	CGA/PRKG1/PIK3R3/PNPLA2	-0.0173848788677357
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/641	90/9376	0.975143005720229	AQP9/ABCB1/RXRA/ABCB4/SCARB1/HMGCR	-0.0641857655919904
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/641	196/9376	0.970167786303289	MAP1LC3B/TCF7L2/GNG4/PIK3R3/MAPK1/ITPR1/IFNAR1/ANGPT2/HLA-G/EP300/PPP3CC/TCF7/IKBKG	-0.114333993964102
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/641	91/9376	0.964427148514512	PRKCB/PIK3R3/MAPK1/PPP3CC/PTPN6/IKBKG	-0.0923701437800653
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/641	76/9376	0.962312176697594	PLIN2/CD36/PDPK1/RXRA/ILK	-0.089361319978718
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/641	76/9376	0.962312176697594	ACTG1/CAMK2A/PRKCB/ITPR1/PRKCG	-0.089361319978718
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/641	13/9376	1.12516500660026	RAD50	0.122329243317741
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/641	138/9376	0.953944244726311	MT-CO3/NDUFB6/ATP5MC1/MT-ATP8/NDUFA11/ATP6V0A2/ATP5MC3/NDUFB1/COX11	-0.147644635261287
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/641	30/9376	0.975143005720229	PDHB/SUCLG1	-0.0369385250121503
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/641	109/9376	0.939357941290129	RORA/IL1R1/MAPK1/RXRA/SMAD4/PPP3CC/IKBKG	-0.172504648403614
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/641	201/9376	0.946034259280819	ZEB1/GADD45A/PBX1/DDX5/FOXO1/RXRA/DOT1L/BCL2L1/HOXA10/NUPR1/ITGAM/PDGFA/TFE3	-0.209505936246265
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/641	78/9376	0.93763750550022	C1S/C1R/ITGB1/MAPK1/ITGAM	-0.149816348374514
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/641	140/9376	0.940316469801649	MAP1LC3B/GNG4/SLC8A2/MAPK1/ITPR1/NRF1/MEF2D/SMAD4/RPS6KB1	-0.192734631206304
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/641	47/9376	0.933647558668304	LDHA/PDHB/LDHB	-0.123529728638636
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/641	63/9376	0.928707624495456	PTGDS/GGT5/PTGES2/PLA2G6	-0.153798378762921
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/641	31/9376	0.943686779729254	CNDP1/CSAD	-0.0850716302795559
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/641	157/9376	0.931665292089391	GADD45A/PIK3R3/FOXO1/MAPK1/ITPR1/RAD50/HLA-G/VDAC3/PPP3CC/HIPK4	-0.233901205129181
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/641	95/9376	0.923819689629691	CXCL12/IL15/CSF1/ATP6V0A2/IL11/CD28	-0.202157730004777
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/641	112/9376	0.914196567862715	LAMB1/LAMA2/ITGB1/MAPK1/PDPK1/BCL2L1/IKBKG	-0.247455776597822
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/641	32/9376	0.914196567862715	SEPTIN4/BCL2L1	-0.131703231958462
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/641	15/9376	0.975143005720229	ACP1	-0.0260985462971834
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/641	98/9376	0.89553949504919	PRKCB/PIK3R3/ITPR1/PRKCG/INPP5A/PIP4P2	-0.281592557946241
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/641	99/9376	0.886493641563844	DLL3/PIK3R3/MAPK1/MMP2/RPS6KB1/ARAF	-0.307551045671189
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/641	99/9376	0.886493641563844	CFD/C1S/FCGR3B/C1R/KRT19/ITGAM	-0.307551045671189
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/641	100/9376	0.877628705148206	CXCL12/CXCL9/CCR7/TNFRSF1B/LTBR/CSF1	-0.333259381363715
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/641	116/9376	0.882672548281242	GAPDH/PDHB/PRPS2/SUCLG1/TALDO1/ENO2/PRPS1	-0.344434255745309
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/641	226/9376	0.906106332748885	CGA/PDE4C/ROCK2/CAMK2A/PDE10A/PIK3R3/MAPK1/CREB3L2/GRIA1/EP300/EDNRA/AFDN/PTCH1/ATP2B4	-0.387046525069461
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/641	149/9376	0.883518830686113	PDGFRB/PIK3R3/MAPK1/RALB/DNM2/LPAR1/CYTH4/PDGFA/KITLG	-0.388241354894935
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/641	52/9376	0.843873754950198	CGA/CYP1B1/SCARB1	-0.30581561192455
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/641	17/9376	0.860420299164908	MYH9	-0.156032547266166
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/641	35/9376	0.83583686204591	PMM2/ENOSF1	-0.263570123105811
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/641	86/9376	0.850415411965316	CAMK2A/PRKCB/CREB3L2/PRKCG/ATF4	-0.377495185095254
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/641	70/9376	0.83583686204591	CD36/TNFRSF1B/RXRA/IKBKG	-0.373444733507801
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/641	103/9376	0.852066704027384	PPP2R2D/UPF3A/RNPS1/TARDBP/MAGOHB/PPP2R1A	-0.408938137108608
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/641	103/9376	0.852066704027384	PIK3R3/MAPK1/PPP2R2D/GNA14/IKBKG/PPP2R1A	-0.408938137108608
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/641	36/9376	0.812619171433524	GALNT13/GCNT1	-0.305130882825062
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/641	87/9376	0.840640522172611	MT-CO3/TPM2/CACNB2/CACNG7/SLC8A2	-0.404516500245832
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/641	136/9376	0.860420299164908	RACK1/SLAMF1/PIK3R3/IFNAR1/BCL2L1/CD28/CSNK2A2/IKBKG	-0.444159473906952
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/641	18/9376	0.812619171433524	CBR4	-0.215552510525874
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/641	18/9376	0.812619171433524	FUCA2	-0.215552510525874
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/641	120/9376	0.8532501300052	CAMK2A/PIK3R3/MAPK1/PDPK1/PRKCD/ABL1/ATF4	-0.438268112615946
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/641	54/9376	0.812619171433524	CGA/HLA-G/CD28	-0.374068108743972
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/641	71/9376	0.82406451187625	CGA/PIK3R3/MAPK1/SOCS5	-0.403095206987177
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/641	105/9376	0.83583686204591	PIK3R3/MAPK1/ITPR1/PRKCD/PPP3CC/IKBKG	-0.458237051947979
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/641	138/9376	0.847950439756721	ACTG1/FN1/ITGB1/ROCK2/PIK3R3/MAPK1/ARHGEF1/IKBKG	-0.487437492455647
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/641	38/9376	0.769849741358075	TAP1/IKBKG	-0.385087595332507
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/641	156/9376	0.843873754950198	PIK3R3/MAPK1/PPP2R2D/IFNAR1/RXRA/SCARB1/ARAF/IKBKG/PPP2R1A	-0.532667195817643
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/641	157/9376	0.838498762880452	MT-CO3/PIK3R3/NDUFB6/RXRA/MLXIP/EIF2AK3/NDUFA11/NDUFB1/ATF4	-0.552798645770624
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/641	39/9376	0.750110004400176	HLA-G/CD28	-0.423604623668609
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/641	20/9376	0.731357254290172	LIPA	-0.32578284167606
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/641	158/9376	0.833191808685006	GADD45A/CDKN1C/SMC3/ANAPC5/EP300/SMAD4/ABL1/ANAPC11/PPP2R1A	-0.572810226945166
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/641	41/9376	0.713519272478216	CHDH/MAOB	-0.497981691935471
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/641	78/9376	0.750110004400176	MTREX/EXOSC6/LSM7/ENO2	-0.600322468438478
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/641	180/9376	0.812619171433524	PIK3R3/TRAF5/IFNAR1/HCFC2/HLA-G/TAP1/SRSF1/BCL2L1/IKBKG/SRSF8	-0.687614655631569
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/641	23/9376	0.63596282981754	ASL	-0.473497160441266
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/641	23/9376	0.63596282981754	ENPEP	-0.473497160441266
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/641	62/9376	0.70776508479694	PIK3R3/FOXO1/RPS6KB1	-0.625378618734745
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/641	44/9376	0.664870231172883	HLA-G/CD28	-0.603580469353334
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/641	24/9376	0.609464378575143	HS3ST2	-0.518916192515405
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/641	250/9376	0.819120124804992	DTNBP1/CD63/VPS39/LIPA/OSBPL2/AP3S1/SNAP29/CLN6/NAGLU/ATP6V0A2/FUCA2/TFE3/AP3M1/SLC17A5	-0.785241456798122
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/641	168/9376	0.783597058168041	PPIA/CAMK2A/TRAF5/VPS4A/CHMP4A/IFNAR1/VPS4B/VDAC3/CHMP3	-0.766687432225472
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/641	45/9376	0.650095337146819	HLA-G/CD28	-0.637345744533284
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/641	66/9376	0.664870231172883	CYP1B1/HSD17B12/SRD5A3	-0.74010499030375
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/641	26/9376	0.562582503300132	PLA2G6	-0.605006746681072
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/641	173/9376	0.760949744348155	ACTG1/CALCOCO2/PRKCB/PIK3R3/MAPK1/IFNAR1/EP300/FDPS/IKBKG	-0.859667980868116
NA	NA	hsa04519	Cadherin signaling	23/641	404/9376	0.832733507360096	ACTG1/VIM/TCF7L2/KRT19/PDGFRB/ROCK2/PRICKLE2/GJA1/CYFIP2/MAPK1/ERBIN/GABRA2/PRICKLE1/TMC4/CSNK1A1/EP300/WNT5A/AFDN/TCF7/IKBKG/WNT2/KRT7/APC2	-0.930975385921386
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/641	48/9376	0.609464378575143	AOX1/IVD	-0.734801782311653
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/641	48/9376	0.609464378575143	PRKCB/PIK3R3	-0.734801782311653
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/641	49/9376	0.597026330032793	GALNT13/COLGALT1	-0.766102572191164
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/641	193/9376	0.757883165067535	CXCL12/ROCK2/GNG4/PRKCB/PIK3R3/CXCL9/CCR7/MAPK1/PRKCD/IKBKG	-0.920649981178901
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/641	69/9376	0.63596282981754	PIK3R3/MAPK1/PDPK1	-0.822145372089772
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/641	69/9376	0.63596282981754	ITPR1/EDNRA/PPP3CC	-0.822145372089772
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/641	28/9376	0.522398038778694	ST3GAL6	-0.685597086926035
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/641	28/9376	0.522398038778694	ATP6V0A2	-0.685597086926035
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/641	195/9376	0.750110004400176	ACTG1/FCGR3B/AQP9/AZU1/PRKCB/PIK3R3/MAPK1/PRKCG/VDAC3/ITGAM	-0.955222139493057
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/641	29/9376	0.504384313303567	SLC24A1	-0.724087615669125
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/641	71/9376	0.618048383907187	ATP6V0A2/IKBKG/JAM2	-0.875109776827539
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/641	51/9376	0.573613532776605	ENPP2/PLA2G6	-0.827079541993143
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/641	109/9376	0.670969958064378	PIK3R3/CXCL9/MAPK1/IFNAR1/IKBKG	-0.935971055499335
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/641	181/9376	0.727316606476414	FCGR3B/CAMK2A/MAPK1/CASP10/EP300/ATP6V0A2/ITGAM/PPP3CC/NFYB	-1.00347211609977
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/641	110/9376	0.664870231172883	PIK3R3/MAPK1/ANAPC5/ARAF/ANAPC11	-0.95773729588748
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/641	30/9376	0.487571502860114	PIGN	-0.761490011442945
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/641	30/9376	0.487571502860114	PLA2G6	-0.761490011442945
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/641	93/9376	0.629124519819503	DLL3/MAPK1/PPP3CC/IKBKG	-0.973662892825738
NA	NA	hsa04081	Hormone signaling	11/641	219/9376	0.734696785131679	CGA/CSH1/PRKG1/GNG4/PIK3R3/SMAD5/ADRA2C/SMAD4/GNA14/RAMP1/ITGAV	-1.07614591458751
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/641	54/9376	0.541746114289016	REV3L/RPA2	-0.914811646761776
Human Diseases	Immune disease	hsa05310	Asthma	1/641	32/9376	0.457098283931357	PRG2	-0.833322267664454
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/641	55/9376	0.531896184938307	SGMS2/CERS2	-0.943138491529492
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/641	33/9376	0.443246820781922	PDHB	-0.867880038285389
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/641	36/9376	0.406309585716762	DHDH	-0.966765285546565
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/641	82/9376	0.535139454358662	HLA-G/TAP1/NFYB	-1.1452794761362
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/641	61/9376	0.479578527403391	SLC8A2/ATP2B4	-1.1046174342599
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/641	83/9376	0.528691991053136	PEX14/ECI2/MPV17	-1.16828579366013
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/641	104/9376	0.562582503300132	SGMS2/CHKB/CRLS1/PLA2G6	-1.21509240781716
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/641	143/9376	0.613726367236508	C1S/FCGR3B/C1R/C9/RO60/CD28	-1.26088321456765
NA	NA	hsa04382	Cornified envelope formation	10/641	217/9376	0.674061985520895	S100A6/S100A16/KRT19/S100A4/COL4A2/PPP2R2D/COL4A1/S100A9/KRT7/PPP2R1A	-1.31590352814506
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/641	43/9376	0.340166164786126	ECI2	-1.17473896700124
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/641	44/9376	0.332435115586442	RFC2	-1.20230777369706
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/641	46/9376	0.31798141490877	UROD	-1.25608058155414
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/641	72/9376	0.406309585716762	CASP10/IKBKG	-1.36985510495992
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/641	73/9376	0.400743700980916	AOX1/MAOB	-1.39234136464173
NA	NA	hsa04082	Neuroactive ligand signaling	8/641	199/9376	0.588025933097625	GNG4/PRKCB/ADRA2C/GABRA2/PRKCG/GRIK5/GRIA1/SLC6A3	-1.59121641166617
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/641	79/9376	0.370307470526669	CYP1B1/DHDH	-1.52248796896818
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/641	191/9376	0.536073380107979	GNG4/MAOB/MAPK1/CREB3L2/ARAF/SLC6A3/ATF4	-1.75472714473896
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/641	83/9376	0.352461327368757	POLR2F/IKBKG	-1.60512916759262
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/641	298/9376	0.589012553790742	CSH1/CXCL12/IL1R1/CXCL9/CCR7/TNFRSF1B/IFNAR1/LTBR/IL15/CSF1/TNFSF15/IL11	-1.95310142776337
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/641	183/9376	0.479578527403391	BMS1/NOP56/LSG1/NOP10/UTP14A/CSNK2A2	-1.92590703851596
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/641	65/9376	0.225033001320053	PNPLA2	-1.69834110952464
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/641	144/9376	0.406309585716762	TCF7L2/FOXO1/TCF7/IKBKG	-1.94480733274469
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/641	66/9376	0.221623410390961	RORA	-1.71897710048684
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/641	70/9376	0.208959215511478	CYP1B1	-1.79949054726119
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/641	78/9376	0.187527501100044	INPP5A	-1.95184082863037
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/641	86/9376	0.170083082393063	GABRA2	-2.09439785570069
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/641	370/9376	0.43486107011848	CGA/CSH1/ADRA2C/GABRA2/GRIK5/LPAR1/GRIA1/EDNRA/S1PR3/BDKRB1/PTGDR	-3.00450764864089
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/641	449/9376	0.130308642189786	PRKG1/SLC8A2/CAMK2A/OR2B11	-5.11586123420158