ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 23/180 168/18639 0.136904761904762 14.1764880952381 3.90608143728437e-20 1.86320084558465e-17 GO:0019838 growth factor binding 16/180 136/18639 0.117647058823529 12.1823529411765 2.78773802533312e-13 4.63190697250363e-11 GO:0030020 extracellular matrix structural constituent conferring tensile strength 11/180 44/18639 0.25 25.8875 2.91314903931046e-13 4.63190697250363e-11 GO:0048407 platelet-derived growth factor binding 6/180 11/18639 0.545454545454545 56.4818181818182 3.31191162722367e-10 3.94945461546423e-08 GO:0005539 glycosaminoglycan binding 15/180 242/18639 0.0619834710743802 6.41838842975207 1.37892133661133e-08 1.31549095512721e-06 GO:0005520 insulin-like growth factor binding 6/180 19/18639 0.315789473684211 32.7 1.82400610863339e-08 1.45008485636354e-06 GO:0005178 integrin binding 12/180 161/18639 0.0745341614906832 7.71801242236025 5.43597358396474e-08 3.70422771364454e-06 GO:0031994 insulin-like growth factor I binding 5/180 13/18639 0.384615384615385 39.8269230769231 9.60393783985734e-08 5.72634793701494e-06 GO:0008201 heparin binding 12/180 172/18639 0.0697674418604651 7.22441860465116 1.12652473394713e-07 5.97058108991977e-06 GO:0001968 fibronectin binding 6/180 30/18639 0.2 20.71 3.6547718322282e-07 1.74332616397285e-05 GO:1901681 sulfur compound binding 14/180 275/18639 0.0509090909090909 5.27163636363636 4.79626285999624e-07 2.07983398565291e-05 GO:0050840 extracellular matrix binding 7/180 67/18639 0.104477611940299 10.8186567164179 3.71936820578594e-06 0.000147844886179991 GO:0005518 collagen binding 7/180 72/18639 0.0972222222222222 10.0673611111111 6.0498518535533e-06 0.000221983025703456 GO:0003735 structural constituent of ribosome 10/180 175/18639 0.0571428571428571 5.91714285714286 7.94696267162682e-06 0.000270764371026142 GO:0046332 SMAD binding 7/180 79/18639 0.0886075949367089 9.1753164556962 1.1247943962535e-05 0.000357684618008613 GO:0061134 peptidase regulator activity 11/180 226/18639 0.0486725663716814 5.04004424778761 1.28063079719063e-05 0.000381788056412456 GO:0016504 peptidase activator activity 6/180 57/18639 0.105263157894737 10.9 1.79975438489869e-05 0.000504989906821575 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/180 68/18639 0.0882352941176471 9.13676470588235 4.97237156540663e-05 0.00131767846483276 GO:0043236 laminin binding 4/180 29/18639 0.137931034482759 14.2827586206897 0.000165416471313812 0.00415282404298359 GO:0140313 molecular sequestering activity 5/180 55/18639 0.0909090909090909 9.41363636363636 0.00018695821934942 0.00445895353148368 GO:0043394 proteoglycan binding 4/180 37/18639 0.108108108108108 11.1945945945946 0.00043310946190505 0.00983777206327185 GO:0009055 electron transfer activity 6/180 116/18639 0.0517241379310345 5.35603448275862 0.000920630794294584 0.019960949494478 GO:0022853 active monoatomic ion transmembrane transporter activity 6/180 118/18639 0.0508474576271186 5.26525423728814 0.0010063263797153 0.0208703340488781 GO:0003779 actin binding 12/180 443/18639 0.0270880361173815 2.80496613995485 0.00127905097891025 0.0254211382058412 GO:0045296 cadherin binding 10/180 334/18639 0.029940119760479 3.10029940119761 0.00155439073750385 0.0296577752715734 GO:0070412 R-SMAD binding 3/180 26/18639 0.115384615384615 11.9480769230769 0.00195551533445206 0.0358761851743705 GO:0002020 protease binding 6/180 136/18639 0.0441176470588235 4.56838235294118 0.00208182569771377 0.03677892065961 GO:0015078 proton transmembrane transporter activity 7/180 185/18639 0.0378378378378378 3.91810810810811 0.00216659603713401 0.0369095110611759 GO:0004857 enzyme inhibitor activity 11/180 416/18639 0.0264423076923077 2.73810096153846 0.00244147175301739 0.0401580009030791 GO:0015026 coreceptor activity 4/180 61/18639 0.0655737704918033 6.79016393442623 0.00285933221742289 0.0454633822570239 GO:0032934 sterol binding 4/180 68/18639 0.0588235294117647 6.09117647058824 0.00423536323299577 0.0631333831918432 GO:1990841 promoter-specific chromatin binding 4/180 68/18639 0.0588235294117647 6.09117647058824 0.00423536323299577 0.0631333831918432 GO:0097493 structural molecule activity conferring elasticity 2/180 11/18639 0.181818181818182 18.8272727272727 0.0048169910722936 0.0692373426476631 GO:0008083 growth factor activity 6/180 162/18639 0.037037037037037 3.83518518518518 0.00493515649899485 0.0692373426476631 GO:0015399 primary active transmembrane transporter activity 6/180 166/18639 0.036144578313253 3.74277108433735 0.00554896151089404 0.0756244183056131 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/180 41/18639 0.0731707317073171 7.57682926829268 0.0072127893328308 0.0932512309651886 GO:0048306 calcium-dependent protein binding 4/180 80/18639 0.05 5.1775 0.00752375035145441 0.0932512309651886 GO:0008307 structural constituent of muscle 3/180 42/18639 0.0714285714285714 7.39642857142857 0.00771323727856984 0.0932512309651886 GO:0035198 miRNA binding 3/180 42/18639 0.0714285714285714 7.39642857142857 0.00771323727856984 0.0932512309651886 GO:0008191 metalloendopeptidase inhibitor activity 2/180 14/18639 0.142857142857143 14.7928571428571 0.00781980972454411 0.0932512309651886 GO:0048156 tau protein binding 3/180 43/18639 0.0697674418604651 7.22441860465116 0.00823370637135572 0.0955969963694223 GO:0003954 NADH dehydrogenase activity 3/180 44/18639 0.0681818181818182 7.06022727272727 0.00877436862951375 0.0955969963694223 GO:0004129 cytochrome-c oxidase activity 2/180 15/18639 0.133333333333333 13.8066666666667 0.00896593544993896 0.0955969963694223 GO:0005523 tropomyosin binding 2/180 15/18639 0.133333333333333 13.8066666666667 0.00896593544993896 0.0955969963694223 GO:0061135 endopeptidase regulator activity 6/180 184/18639 0.0326086956521739 3.37663043478261 0.00901858456315304 0.0955969963694223 GO:0005159 insulin-like growth factor receptor binding 2/180 16/18639 0.125 12.94375 0.0101821906926346 0.101185520008057 GO:0008142 oxysterol binding 2/180 16/18639 0.125 12.94375 0.0101821906926346 0.101185520008057 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/180 16/18639 0.125 12.94375 0.0101821906926346 0.101185520008057 GO:0043178 alcohol binding 4/180 92/18639 0.0434782608695652 4.50217391304348 0.0121626322456123 0.118399501656267 GO:0098641 cadherin binding involved in cell-cell adhesion 2/180 18/18639 0.111111111111111 11.5055555555556 0.0128193272646521 0.122296382104781 GO:0043395 heparan sulfate proteoglycan binding 2/180 19/18639 0.105263157894737 10.9 0.0142373798795432 0.133161376520433 GO:0015485 cholesterol binding 3/180 54/18639 0.0555555555555556 5.75277777777778 0.0153220269941919 0.137898242947727 GO:0140463 chromatin-protein adaptor activity 3/180 54/18639 0.0555555555555556 5.75277777777778 0.0153220269941919 0.137898242947727 GO:0072542 protein phosphatase activator activity 2/180 21/18639 0.0952380952380952 9.86190476190476 0.0172655367307788 0.152512241121879 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/180 58/18639 0.0517241379310345 5.35603448275862 0.0185359501161374 0.157886575096385 GO:0061980 regulatory RNA binding 3/180 58/18639 0.0517241379310345 5.35603448275862 0.0185359501161374 0.157886575096385 GO:0030246 carbohydrate binding 7/180 280/18639 0.025 2.58875 0.0192538719723165 0.158523313110847 GO:0004879 nuclear receptor activity 3/180 59/18639 0.0508474576271186 5.26525423728814 0.0193933469329022 0.158523313110847 GO:0019888 protein phosphatase regulator activity 4/180 107/18639 0.0373831775700935 3.87102803738318 0.020113567921024 0.158523313110847 GO:0004866 endopeptidase inhibitor activity 5/180 161/18639 0.031055900621118 3.21583850931677 0.0201327602650026 0.158523313110847 GO:0098531 ligand-modulated transcription factor activity 3/180 60/18639 0.05 5.1775 0.0202723733747623 0.158523313110847 GO:0005496 steroid binding 4/180 108/18639 0.037037037037037 3.83518518518518 0.0207342849278661 0.159520224364389 GO:0019211 phosphatase activator activity 2/180 25/18639 0.08 8.284 0.0240525884806954 0.176449190897927 GO:0030414 peptidase inhibitor activity 5/180 169/18639 0.029585798816568 3.06360946745562 0.024218435207234 0.176449190897927 GO:0019843 rRNA binding 3/180 65/18639 0.0461538461538462 4.77923076923077 0.02499234821176 0.176449190897927 GO:0038024 cargo receptor activity 3/180 65/18639 0.0461538461538462 4.77923076923077 0.02499234821176 0.176449190897927 GO:0008143 poly(A) binding 2/180 26/18639 0.0769230769230769 7.96538461538462 0.0258940112428823 0.176449190897927 GO:0043548 phosphatidylinositol 3-kinase binding 2/180 26/18639 0.0769230769230769 7.96538461538462 0.0258940112428823 0.176449190897927 GO:0050681 nuclear androgen receptor binding 2/180 26/18639 0.0769230769230769 7.96538461538462 0.0258940112428823 0.176449190897927 GO:0050750 low-density lipoprotein particle receptor binding 2/180 26/18639 0.0769230769230769 7.96538461538462 0.0258940112428823 0.176449190897927 GO:0019208 phosphatase regulator activity 4/180 117/18639 0.0341880341880342 3.54017094017094 0.0268515249933109 0.179137843819622 GO:0031625 ubiquitin protein ligase binding 7/180 302/18639 0.0231788079470199 2.40016556291391 0.0276396319331133 0.179137843819622 GO:0008266 poly(U) RNA binding 2/180 27/18639 0.0740740740740741 7.67037037037037 0.0277907766093333 0.179137843819622 GO:0023026 MHC class II protein complex binding 2/180 27/18639 0.0740740740740741 7.67037037037037 0.0277907766093333 0.179137843819622 GO:0097718 disordered domain specific binding 2/180 28/18639 0.0714285714285714 7.39642857142857 0.0297416566550013 0.187410858024699 GO:0051082 unfolded protein binding 4/180 121/18639 0.0330578512396694 3.42314049586777 0.0298818702604647 0.187410858024699 GO:0097110 scaffold protein binding 3/180 70/18639 0.0428571428571429 4.43785714285714 0.0302529058027292 0.187410858024699 GO:0008187 poly-pyrimidine tract binding 2/180 30/18639 0.0666666666666667 6.90333333333333 0.0338009404608849 0.206201018130022 GO:0042277 peptide binding 6/180 249/18639 0.0240963855421687 2.49518072289157 0.0341506927301294 0.206201018130022 GO:0017147 Wnt-protein binding 2/180 31/18639 0.0645161290322581 6.68064516129032 0.0359069790425405 0.20673483719369 GO:0070325 lipoprotein particle receptor binding 2/180 31/18639 0.0645161290322581 6.68064516129032 0.0359069790425405 0.20673483719369 GO:0003725 double-stranded RNA binding 3/180 75/18639 0.04 4.142 0.0360498221789183 0.20673483719369 GO:0035591 signaling adaptor activity 4/180 129/18639 0.0310077519379845 3.21085271317829 0.0365275486959509 0.20673483719369 GO:0044389 ubiquitin-like protein ligase binding 7/180 322/18639 0.0217391304347826 2.25108695652174 0.0371646459845405 0.20673483719369 GO:0017022 myosin binding 3/180 76/18639 0.0394736842105263 4.0875 0.0372729475862837 0.20673483719369 GO:0098631 cell adhesion mediator activity 3/180 76/18639 0.0394736842105263 4.0875 0.0372729475862837 0.20673483719369 GO:0070717 poly-purine tract binding 2/180 32/18639 0.0625 6.471875 0.0380624014824541 0.208686959852076 GO:0140311 protein sequestering activity 2/180 33/18639 0.0606060606060606 6.27575757575758 0.0402660691355318 0.21826039747328 GO:0001540 amyloid-beta binding 3/180 83/18639 0.036144578313253 3.74277108433735 0.0464201835995535 0.248791321089742 GO:0020037 heme binding 4/180 142/18639 0.028169014084507 2.9169014084507 0.049004522477377 0.259682025098939 GO:0023023 MHC protein complex binding 2/180 37/18639 0.0540540540540541 5.5972972972973 0.0495410152704475 0.259682025098939 GO:0019955 cytokine binding 4/180 144/18639 0.0277777777777778 2.87638888888889 0.0511084227321474 0.264986061339503 GO:0051015 actin filament binding 5/180 209/18639 0.0239234449760766 2.47727272727273 0.0524184282581168 0.268855809452922 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 7/180 349/18639 0.0200573065902579 2.0769340974212 0.0531355573952464 0.268969224159487 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/180 88/18639 0.0340909090909091 3.53011363636364 0.053568294119814 0.268969224159487 GO:0003727 single-stranded RNA binding 3/180 89/18639 0.0337078651685393 3.49044943820225 0.0550578971188407 0.27356892630924 GO:0042169 SH2 domain binding 2/180 41/18639 0.0487804878048781 5.05121951219512 0.0595011651466216 0.29209700241562 GO:0046906 tetrapyrrole binding 4/180 152/18639 0.0263157894736842 2.725 0.0600115434732301 0.29209700241562 GO:0042056 chemoattractant activity 2/180 42/18639 0.0476190476190476 4.93095238095238 0.0620905615400242 0.299163614692844 GO:0042562 hormone binding 3/180 94/18639 0.0319148936170213 3.30478723404255 0.0627988072563969 0.299550310613013 GO:0004867 serine-type endopeptidase inhibitor activity 3/180 95/18639 0.0315789473684211 3.27 0.06440461296707 0.30265053846704 GO:0008200 ion channel inhibitor activity 2/180 43/18639 0.0465116279069767 4.81627906976744 0.0647177252067885 0.30265053846704 GO:0016248 channel inhibitor activity 2/180 44/18639 0.0454545454545455 4.70681818181818 0.0673816945676111 0.309048733737986 GO:0030547 signaling receptor inhibitor activity 2/180 44/18639 0.0454545454545455 4.70681818181818 0.0673816945676111 0.309048733737986 GO:0141110 transporter inhibitor activity 2/180 45/18639 0.0444444444444444 4.60222222222222 0.0700815229080676 0.318370346925221 GO:0001222 transcription corepressor binding 2/180 49/18639 0.0408163265306122 4.2265306122449 0.0812210012068708 0.34965086048774 GO:0008013 beta-catenin binding 3/180 106/18639 0.0283018867924528 2.93066037735849 0.0832808559173783 0.34965086048774 GO:0005021 vascular endothelial growth factor receptor activity 2/180 51/18639 0.0392156862745098 4.06078431372549 0.0869823398972377 0.34965086048774 GO:0005080 protein kinase C binding 2/180 52/18639 0.0384615384615385 3.98269230769231 0.0899078814244561 0.34965086048774 GO:0004222 metalloendopeptidase activity 3/180 110/18639 0.0272727272727273 2.82409090909091 0.0906705421410664 0.34965086048774 GO:0004252 serine-type endopeptidase activity 4/180 176/18639 0.0227272727272727 2.35340909090909 0.0912644079051852 0.34965086048774 GO:0033218 amide binding 5/180 247/18639 0.0202429149797571 2.09615384615385 0.0917181944928067 0.34965086048774 GO:0005522 profilin binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0015279 store-operated calcium channel activity 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0030957 Tat protein binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0035256 G protein-coupled glutamate receptor binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0035374 chondroitin sulfate binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0070513 death domain binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0098505 G-rich strand telomeric DNA binding 1/180 10/18639 0.1 10.355 0.0925026054474404 0.34965086048774 GO:0043021 ribonucleoprotein complex binding 4/180 177/18639 0.0225988700564972 2.34011299435028 0.092708576594086 0.34965086048774 GO:0004864 protein phosphatase inhibitor activity 2/180 53/18639 0.0377358490566038 3.90754716981132 0.0928622204645794 0.34965086048774 GO:0016860 intramolecular oxidoreductase activity 2/180 53/18639 0.0377358490566038 3.90754716981132 0.0928622204645794 0.34965086048774 GO:0017046 peptide hormone binding 2/180 53/18639 0.0377358490566038 3.90754716981132 0.0928622204645794 0.34965086048774 GO:0005200 structural constituent of cytoskeleton 3/180 112/18639 0.0267857142857143 2.77366071428571 0.0944648191205531 0.34965086048774 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 8/180 484/18639 0.0165289256198347 1.71157024793388 0.0978220114396322 0.34965086048774 GO:0004175 endopeptidase activity 7/180 405/18639 0.0172839506172839 1.78975308641975 0.0983208278228755 0.34965086048774 GO:0098632 cell-cell adhesion mediator activity 2/180 55/18639 0.0363636363636364 3.76545454545455 0.0988540184247853 0.34965086048774 GO:0001221 transcription coregulator binding 3/180 115/18639 0.0260869565217391 2.70130434782609 0.100276601797524 0.34965086048774 GO:0002162 dystroglycan binding 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0019215 intermediate filament binding 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0050786 RAGE receptor binding 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0050998 nitric-oxide synthase binding 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0070697 activin receptor binding 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:1990948 ubiquitin ligase inhibitor activity 1/180 11/18639 0.0909090909090909 9.41363636363636 0.101271166884955 0.34965086048774 GO:0140297 DNA-binding transcription factor binding 8/180 488/18639 0.0163934426229508 1.69754098360656 0.101308391848913 0.34965086048774 GO:0019212 phosphatase inhibitor activity 2/180 56/18639 0.0357142857142857 3.69821428571429 0.101889873391606 0.34965086048774 GO:0001216 DNA-binding transcription activator activity 8/180 491/18639 0.0162932790224033 1.68716904276986 0.103968732934124 0.354236325782694 GO:0004859 phospholipase inhibitor activity 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0005049 nuclear export signal receptor activity 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0005078 MAP-kinase scaffold activity 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0035497 cAMP response element binding 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0043047 single-stranded telomeric DNA binding 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0070679 inositol 1,4,5 trisphosphate binding 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:1990459 transferrin receptor binding 1/180 12/18639 0.0833333333333333 8.62916666666667 0.109955469545504 0.355822486988209 GO:0003730 mRNA 3'-UTR binding 5/180 262/18639 0.0190839694656489 1.97614503816794 0.110491613271475 0.355822486988209 GO:0036002 pre-mRNA binding 2/180 59/18639 0.0338983050847458 3.51016949152542 0.111147904740552 0.355822486988209 GO:0019902 phosphatase binding 4/180 190/18639 0.0210526315789474 2.18 0.112451220689027 0.357594881791107 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/180 60/18639 0.0333333333333333 3.45166666666667 0.114281543753165 0.361008585233508 GO:0017154 semaphorin receptor activity 1/180 13/18639 0.0769230769230769 7.96538461538462 0.118556318607715 0.36582559021231 GO:0043560 insulin receptor substrate binding 1/180 13/18639 0.0769230769230769 7.96538461538462 0.118556318607715 0.36582559021231 GO:0045159 myosin II binding 1/180 13/18639 0.0769230769230769 7.96538461538462 0.118556318607715 0.36582559021231 GO:0008236 serine-type peptidase activity 4/180 194/18639 0.0206185567010309 2.13505154639175 0.118874143570038 0.36582559021231 GO:0017171 serine hydrolase activity 4/180 198/18639 0.0202020202020202 2.09191919191919 0.125453014838304 0.367360860803597 GO:0004065 arylsulfatase activity 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0008195 phosphatidate phosphatase activity 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0008331 high voltage-gated calcium channel activity 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0008494 translation activator activity 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0032036 myosin heavy chain binding 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0042043 neurexin family protein binding 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0044548 S100 protein binding 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0046030 inositol trisphosphate phosphatase activity 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0098847 sequence-specific single stranded DNA binding 1/180 14/18639 0.0714285714285714 7.39642857142857 0.127074511598728 0.367360860803597 GO:0030553 cGMP binding 1/180 15/18639 0.0666666666666667 6.90333333333333 0.135510838466499 0.38475398778881 GO:0051371 muscle alpha-actinin binding 1/180 15/18639 0.0666666666666667 6.90333333333333 0.135510838466499 0.38475398778881 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/180 15/18639 0.0666666666666667 6.90333333333333 0.135510838466499 0.38475398778881 GO:0004708 MAP kinase kinase activity 1/180 16/18639 0.0625 6.471875 0.143866081651423 0.403671299692523 GO:0055102 lipase inhibitor activity 1/180 16/18639 0.0625 6.471875 0.143866081651423 0.403671299692523 GO:0016922 nuclear receptor binding 3/180 137/18639 0.0218978102189781 2.26751824817518 0.146860978425081 0.409664834554174 GO:0008484 sulfuric ester hydrolase activity 1/180 17/18639 0.0588235294117647 6.09117647058824 0.15214101615729 0.412336731289928 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/180 17/18639 0.0588235294117647 6.09117647058824 0.15214101615729 0.412336731289928 GO:0045236 CXCR chemokine receptor binding 1/180 17/18639 0.0588235294117647 6.09117647058824 0.15214101615729 0.412336731289928 GO:0070492 oligosaccharide binding 1/180 17/18639 0.0588235294117647 6.09117647058824 0.15214101615729 0.412336731289928 GO:1990226 histone methyltransferase binding 1/180 17/18639 0.0588235294117647 6.09117647058824 0.15214101615729 0.412336731289928 GO:0004713 protein tyrosine kinase activity 3/180 140/18639 0.0214285714285714 2.21892857142857 0.153689220661747 0.414179425173182 GO:0003746 translation elongation factor activity 1/180 18/18639 0.0555555555555556 5.75277777777778 0.160336409621562 0.42489148549714 GO:0031690 adrenergic receptor binding 1/180 18/18639 0.0555555555555556 5.75277777777778 0.160336409621562 0.42489148549714 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/180 18/18639 0.0555555555555556 5.75277777777778 0.160336409621562 0.42489148549714 GO:0019903 protein phosphatase binding 3/180 144/18639 0.0208333333333333 2.15729166666667 0.162945934706725 0.428807751934038 GO:0044183 protein folding chaperone 2/180 75/18639 0.0266666666666667 2.76133333333333 0.163612182079654 0.428807751934038 GO:0003756 protein disulfide isomerase activity 1/180 19/18639 0.0526315789473684 5.45 0.168453022385008 0.432000492890585 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/180 19/18639 0.0526315789473684 5.45 0.168453022385008 0.432000492890585 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/180 19/18639 0.0526315789473684 5.45 0.168453022385008 0.432000492890585 GO:0042577 lipid phosphatase activity 1/180 19/18639 0.0526315789473684 5.45 0.168453022385008 0.432000492890585 GO:0019199 transmembrane receptor protein kinase activity 2/180 78/18639 0.0256410256410256 2.65512820512821 0.173892397766152 0.43875659989254 GO:0016004 phospholipase activator activity 1/180 20/18639 0.05 5.1775 0.176491607560663 0.43875659989254 GO:0016505 peptidase activator activity involved in apoptotic process 1/180 20/18639 0.05 5.1775 0.176491607560663 0.43875659989254 GO:0052745 inositol phosphate phosphatase activity 1/180 20/18639 0.05 5.1775 0.176491607560663 0.43875659989254 GO:0033293 monocarboxylic acid binding 2/180 79/18639 0.0253164556962025 2.62151898734177 0.177342369885302 0.43875659989254 GO:0001618 virus receptor activity 2/180 81/18639 0.0246913580246914 2.55679012345679 0.184273946992129 0.43875659989254 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0001846 opsonin binding 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0009975 cyclase activity 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0010314 phosphatidylinositol-5-phosphate binding 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0036122 BMP binding 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0070182 DNA polymerase binding 1/180 21/18639 0.0476190476190476 4.93095238095238 0.184452911102157 0.43875659989254 GO:0140272 exogenous protein binding 2/180 82/18639 0.024390243902439 2.52560975609756 0.187754511532861 0.43875659989254 GO:0019001 guanyl nucleotide binding 6/180 400/18639 0.015 1.55325 0.191095506877752 0.43875659989254 GO:0032561 guanyl ribonucleotide binding 6/180 400/18639 0.015 1.55325 0.191095506877752 0.43875659989254 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/180 22/18639 0.0454545454545455 4.70681818181818 0.192337671871392 0.43875659989254 GO:0050321 tau-protein kinase activity 1/180 22/18639 0.0454545454545455 4.70681818181818 0.192337671871392 0.43875659989254 GO:0061133 endopeptidase activator activity 1/180 22/18639 0.0454545454545455 4.70681818181818 0.192337671871392 0.43875659989254 GO:0004860 protein kinase inhibitor activity 2/180 84/18639 0.0238095238095238 2.46547619047619 0.194742658447824 0.43875659989254 GO:0003887 DNA-directed DNA polymerase activity 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0005158 insulin receptor binding 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0005212 structural constituent of eye lens 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0016849 phosphorus-oxygen lyase activity 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0017134 fibroblast growth factor binding 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0031681 G-protein beta-subunit binding 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0043274 phospholipase binding 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0099186 structural constituent of postsynapse 1/180 23/18639 0.0434782608695652 4.50217391304348 0.200146621705584 0.43875659989254 GO:0099106 ion channel regulator activity 3/180 160/18639 0.01875 1.9415625 0.20148834166539 0.43875659989254 GO:0016209 antioxidant activity 2/180 86/18639 0.0232558139534884 2.40813953488372 0.201763552193358 0.43875659989254 GO:0008081 phosphoric diester hydrolase activity 2/180 87/18639 0.0229885057471264 2.38045977011494 0.205285082309623 0.43875659989254 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0005540 hyaluronic acid binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0030215 semaphorin receptor binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0035035 histone acetyltransferase binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0048027 mRNA 5'-UTR binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0050431 transforming growth factor beta binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0060229 lipase activator activity 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/180 24/18639 0.0416666666666667 4.31458333333333 0.207880485483677 0.43875659989254 GO:0000030 mannosyltransferase activity 1/180 25/18639 0.04 4.142 0.215539981192135 0.443874120014366 GO:0001848 complement binding 1/180 25/18639 0.04 4.142 0.215539981192135 0.443874120014366 GO:0008483 transaminase activity 1/180 25/18639 0.04 4.142 0.215539981192135 0.443874120014366 GO:0042974 nuclear retinoic acid receptor binding 1/180 25/18639 0.04 4.142 0.215539981192135 0.443874120014366 GO:0120020 cholesterol transfer activity 1/180 25/18639 0.04 4.142 0.215539981192135 0.443874120014366 GO:0019210 kinase inhibitor activity 2/180 90/18639 0.0222222222222222 2.30111111111111 0.21588846088749 0.443874120014366 GO:0016247 channel regulator activity 3/180 168/18639 0.0178571428571429 1.84910714285714 0.221507480563052 0.450978881929154 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/180 26/18639 0.0384615384615385 3.98269230769231 0.223125819990105 0.450978881929154 GO:0004435 phosphatidylinositol phospholipase C activity 1/180 26/18639 0.0384615384615385 3.98269230769231 0.223125819990105 0.450978881929154 GO:0005112 Notch binding 1/180 26/18639 0.0384615384615385 3.98269230769231 0.223125819990105 0.450978881929154 GO:0141108 transporter regulator activity 3/180 170/18639 0.0176470588235294 1.82735294117647 0.226575017118744 0.454606045011111 GO:0001671 ATPase activator activity 1/180 27/18639 0.037037037037037 3.83518518518518 0.230638706273981 0.454606045011111 GO:0005044 scavenger receptor activity 1/180 27/18639 0.037037037037037 3.83518518518518 0.230638706273981 0.454606045011111 GO:0005104 fibroblast growth factor receptor binding 1/180 27/18639 0.037037037037037 3.83518518518518 0.230638706273981 0.454606045011111 GO:0015252 proton channel activity 1/180 27/18639 0.037037037037037 3.83518518518518 0.230638706273981 0.454606045011111 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/180 27/18639 0.037037037037037 3.83518518518518 0.230638706273981 0.454606045011111 GO:0019887 protein kinase regulator activity 4/180 255/18639 0.0156862745098039 1.6243137254902 0.233090494112207 0.457548006960998 GO:0045499 chemorepellent activity 1/180 28/18639 0.0357142857142857 3.69821428571429 0.238079337741351 0.457918726220259 GO:0046875 ephrin receptor binding 1/180 28/18639 0.0357142857142857 3.69821428571429 0.238079337741351 0.457918726220259 GO:0051019 mitogen-activated protein kinase binding 1/180 28/18639 0.0357142857142857 3.69821428571429 0.238079337741351 0.457918726220259 GO:0051393 alpha-actinin binding 1/180 28/18639 0.0357142857142857 3.69821428571429 0.238079337741351 0.457918726220259 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/180 28/18639 0.0357142857142857 3.69821428571429 0.238079337741351 0.457918726220259 GO:0003785 actin monomer binding 1/180 29/18639 0.0344827586206897 3.57068965517241 0.245448405454346 0.466449758572602 GO:0004629 phospholipase C activity 1/180 29/18639 0.0344827586206897 3.57068965517241 0.245448405454346 0.466449758572602 GO:0106222 lncRNA binding 1/180 29/18639 0.0344827586206897 3.57068965517241 0.245448405454346 0.466449758572602 GO:0016769 transferase activity, transferring nitrogenous groups 1/180 30/18639 0.0333333333333333 3.45166666666667 0.252746593902396 0.4709379894197 GO:0033612 receptor serine/threonine kinase binding 1/180 30/18639 0.0333333333333333 3.45166666666667 0.252746593902396 0.4709379894197 GO:0048019 receptor antagonist activity 1/180 30/18639 0.0333333333333333 3.45166666666667 0.252746593902396 0.4709379894197 GO:0051721 protein phosphatase 2A binding 1/180 30/18639 0.0333333333333333 3.45166666666667 0.252746593902396 0.4709379894197 GO:0098918 structural constituent of synapse 1/180 30/18639 0.0333333333333333 3.45166666666667 0.252746593902396 0.4709379894197 GO:0008237 metallopeptidase activity 3/180 184/18639 0.016304347826087 1.6883152173913 0.262601637598704 0.487396813753236 GO:0071813 lipoprotein particle binding 1/180 32/18639 0.03125 3.2359375 0.267133038470261 0.488208656514614 GO:0071814 protein-lipid complex binding 1/180 32/18639 0.03125 3.2359375 0.267133038470261 0.488208656514614 GO:0120015 sterol transfer activity 1/180 32/18639 0.03125 3.2359375 0.267133038470261 0.488208656514614 GO:0140142 nucleocytoplasmic carrier activity 1/180 32/18639 0.03125 3.2359375 0.267133038470261 0.488208656514614 GO:0019956 chemokine binding 1/180 33/18639 0.0303030303030303 3.13787878787879 0.274222631261971 0.497354354037871 GO:0071889 14-3-3 protein binding 1/180 33/18639 0.0303030303030303 3.13787878787879 0.274222631261971 0.497354354037871 GO:0022804 active transmembrane transporter activity 6/180 457/18639 0.0131291028446389 1.35951859956236 0.280582236670112 0.498711511922439 GO:0008376 acetylgalactosaminyltransferase activity 1/180 34/18639 0.0294117647058824 3.04558823529412 0.281244018253954 0.498711511922439 GO:0015035 protein-disulfide reductase activity 1/180 34/18639 0.0294117647058824 3.04558823529412 0.281244018253954 0.498711511922439 GO:0019825 oxygen binding 1/180 34/18639 0.0294117647058824 3.04558823529412 0.281244018253954 0.498711511922439 GO:0030332 cyclin binding 1/180 34/18639 0.0294117647058824 3.04558823529412 0.281244018253954 0.498711511922439 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/180 34/18639 0.0294117647058824 3.04558823529412 0.281244018253954 0.498711511922439 GO:0034061 DNA polymerase activity 1/180 35/18639 0.0285714285714286 2.95857142857143 0.288197851992965 0.509149538520904 GO:1902936 phosphatidylinositol bisphosphate binding 2/180 111/18639 0.018018018018018 1.86576576576577 0.290879949260489 0.511991645008314 GO:0043022 ribosome binding 2/180 112/18639 0.0178571428571429 1.84910714285714 0.294451133444851 0.515587690461122 GO:0055106 ubiquitin-protein transferase regulator activity 1/180 36/18639 0.0277777777777778 2.87638888888889 0.295084778817372 0.515587690461122 GO:0019207 kinase regulator activity 4/180 287/18639 0.0139372822299652 1.44320557491289 0.30108584374577 0.520355599854578 GO:0030551 cyclic nucleotide binding 1/180 37/18639 0.027027027027027 2.79864864864865 0.301905438915898 0.520355599854578 GO:0042805 actinin binding 1/180 37/18639 0.027027027027027 2.79864864864865 0.301905438915898 0.520355599854578 GO:0005525 GTP binding 5/180 378/18639 0.0132275132275132 1.36970899470899 0.302177151278235 0.520355599854578 GO:0035401 histone H3Y41 kinase activity 2/180 115/18639 0.0173913043478261 1.80086956521739 0.305148872996858 0.521706137704305 GO:0140801 histone H2AXY142 kinase activity 2/180 115/18639 0.0173913043478261 1.80086956521739 0.305148872996858 0.521706137704305 GO:0005501 retinoid binding 1/180 38/18639 0.0263157894736842 2.725 0.3086604663858 0.522095895269599 GO:0019840 isoprenoid binding 1/180 38/18639 0.0263157894736842 2.725 0.3086604663858 0.522095895269599 GO:0042162 telomeric DNA binding 1/180 38/18639 0.0263157894736842 2.725 0.3086604663858 0.522095895269599 GO:1990782 protein tyrosine kinase binding 2/180 117/18639 0.0170940170940171 1.77008547008547 0.312264747203085 0.526326093342302 GO:0015036 disulfide oxidoreductase activity 1/180 40/18639 0.025 2.58875 0.321976129716734 0.535034742126971 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/180 40/18639 0.025 2.58875 0.321976129716734 0.535034742126971 GO:0140662 ATP-dependent protein folding chaperone 1/180 40/18639 0.025 2.58875 0.321976129716734 0.535034742126971 GO:0001664 G protein-coupled receptor binding 4/180 297/18639 0.0134680134680135 1.39461279461279 0.322857949631533 0.535034742126971 GO:0005516 calmodulin binding 3/180 207/18639 0.0144927536231884 1.50072463768116 0.323039844303077 0.535034742126971 GO:0003697 single-stranded DNA binding 2/180 121/18639 0.0165289256198347 1.71157024793388 0.326448715167505 0.538531367104401 GO:0001530 lipopolysaccharide binding 1/180 41/18639 0.024390243902439 2.52560975609756 0.328538003830987 0.538531367104401 GO:0042287 MHC protein binding 1/180 41/18639 0.024390243902439 2.52560975609756 0.328538003830987 0.538531367104401 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/180 122/18639 0.0163934426229508 1.69754098360656 0.329983291753336 0.539048048514867 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/180 43/18639 0.0232558139534884 2.40813953488372 0.341472888524427 0.554022339544733 GO:0005245 voltage-gated calcium channel activity 1/180 43/18639 0.0232558139534884 2.40813953488372 0.341472888524427 0.554022339544733 GO:0001046 core promoter sequence-specific DNA binding 1/180 44/18639 0.0227272727272727 2.35340909090909 0.347847102337376 0.558663527996391 GO:0001223 transcription coactivator binding 1/180 44/18639 0.0227272727272727 2.35340909090909 0.347847102337376 0.558663527996391 GO:0043014 alpha-tubulin binding 1/180 44/18639 0.0227272727272727 2.35340909090909 0.347847102337376 0.558663527996391 GO:0031490 chromatin DNA binding 2/180 128/18639 0.015625 1.61796875 0.351076842687235 0.561198842784976 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/180 45/18639 0.0222222222222222 2.30111111111111 0.354159956415315 0.561198842784976 GO:0008009 chemokine activity 1/180 45/18639 0.0222222222222222 2.30111111111111 0.354159956415315 0.561198842784976 GO:0051539 4 iron, 4 sulfur cluster binding 1/180 45/18639 0.0222222222222222 2.30111111111111 0.354159956415315 0.561198842784976 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/180 46/18639 0.0217391304347826 2.25108695652174 0.360412038153792 0.561198842784976 GO:0005262 calcium channel activity 2/180 131/18639 0.0152671755725191 1.58091603053435 0.361540621720378 0.561198842784976 GO:0031072 heat shock protein binding 2/180 131/18639 0.0152671755725191 1.58091603053435 0.361540621720378 0.561198842784976 GO:0005179 hormone activity 2/180 132/18639 0.0151515151515152 1.56893939393939 0.365014889697723 0.561198842784976 GO:0005504 fatty acid binding 1/180 47/18639 0.0212765957446809 2.2031914893617 0.366603929356519 0.561198842784976 GO:0051087 protein-folding chaperone binding 2/180 134/18639 0.0149253731343284 1.5455223880597 0.371941791778106 0.561198842784976 GO:0032266 phosphatidylinositol-3-phosphate binding 1/180 48/18639 0.0208333333333333 2.15729166666667 0.372736206288309 0.561198842784976 GO:0140693 molecular condensate scaffold activity 1/180 48/18639 0.0208333333333333 2.15729166666667 0.372736206288309 0.561198842784976 GO:0005004 GPI-linked ephrin receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0005008 hepatocyte growth factor receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0005009 insulin receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0005011 macrophage colony-stimulating factor receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0005020 stem cell factor receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0008288 boss receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0035254 glutamate receptor binding 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0036332 placental growth factor receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0038062 protein tyrosine kinase collagen receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0060175 brain-derived neurotrophic factor receptor activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0060590 ATPase regulator activity 1/180 49/18639 0.0204081632653061 2.11326530612245 0.378809439727505 0.561198842784976 GO:0044325 transmembrane transporter binding 2/180 136/18639 0.0147058823529412 1.52279411764706 0.378838631817111 0.561198842784976 GO:0005006 epidermal growth factor receptor activity 1/180 50/18639 0.02 2.071 0.384824195017933 0.563060263056333 GO:0005007 fibroblast growth factor receptor activity 1/180 50/18639 0.02 2.071 0.384824195017933 0.563060263056333 GO:0005017 platelet-derived growth factor receptor activity 1/180 50/18639 0.02 2.071 0.384824195017933 0.563060263056333 GO:0005019 platelet-derived growth factor beta-receptor activity 1/180 50/18639 0.02 2.071 0.384824195017933 0.563060263056333 GO:0070851 growth factor receptor binding 2/180 139/18639 0.0143884892086331 1.48992805755396 0.38912447551852 0.563060263056333 GO:0140767 enzyme-substrate adaptor activity 2/180 139/18639 0.0143884892086331 1.48992805755396 0.38912447551852 0.563060263056333 GO:0005010 insulin-like growth factor receptor activity 1/180 51/18639 0.0196078431372549 2.03039215686274 0.390781032120347 0.563060263056333 GO:0005030 neurotrophin receptor activity 1/180 51/18639 0.0196078431372549 2.03039215686274 0.390781032120347 0.563060263056333 GO:0030544 Hsp70 protein binding 1/180 51/18639 0.0196078431372549 2.03039215686274 0.390781032120347 0.563060263056333 GO:0005125 cytokine activity 3/180 234/18639 0.0128205128205128 1.3275641025641 0.394024215025308 0.563060263056333 GO:0030159 signaling receptor complex adaptor activity 1/180 52/18639 0.0192307692307692 1.99134615384615 0.396680505663403 0.563060263056333 GO:0005003 ephrin receptor activity 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0005005 transmembrane-ephrin receptor activity 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0005246 calcium channel regulator activity 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0005544 calcium-dependent phospholipid binding 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0008146 sulfotransferase activity 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0038064 collagen receptor activity 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0051018 protein kinase A binding 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0140296 general transcription initiation factor binding 1/180 53/18639 0.0188679245283019 1.95377358490566 0.40252316499415 0.563060263056333 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/180 54/18639 0.0185185185185185 1.91759259259259 0.408309554228039 0.569484378265422 GO:0015085 calcium ion transmembrane transporter activity 2/180 147/18639 0.0136054421768707 1.40884353741497 0.416174393426116 0.578761474239818 GO:0004601 peroxidase activity 1/180 57/18639 0.0175438596491228 1.81666666666667 0.425336465066295 0.589783412315764 GO:0001786 phosphatidylserine binding 1/180 59/18639 0.0169491525423729 1.75508474576271 0.436416132977185 0.598191078822176 GO:0015459 potassium channel regulator activity 1/180 59/18639 0.0169491525423729 1.75508474576271 0.436416132977185 0.598191078822176 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/180 59/18639 0.0169491525423729 1.75508474576271 0.436416132977185 0.598191078822176 GO:0070888 E-box binding 1/180 59/18639 0.0169491525423729 1.75508474576271 0.436416132977185 0.598191078822176 GO:0005506 iron ion binding 2/180 154/18639 0.012987012987013 1.34480519480519 0.43934638102189 0.600482016468314 GO:0141003 histone H2AX kinase activity 4/180 354/18639 0.0112994350282486 1.17005649717514 0.447013369277494 0.60921536327247 GO:0140996 histone H3 kinase activity 4/180 357/18639 0.0112044817927171 1.16022408963585 0.453416112907785 0.616180871387502 GO:0035173 histone kinase activity 4/180 360/18639 0.0111111111111111 1.15055555555556 0.459795185601988 0.623074725943603 GO:0042578 phosphoric ester hydrolase activity 4/180 363/18639 0.0110192837465565 1.14104683195592 0.466149298121771 0.629895793779276 GO:0120013 lipid transfer activity 1/180 65/18639 0.0153846153846154 1.59307692307692 0.468396536071858 0.631144485045979 GO:0016500 protein-hormone receptor activity 1/180 67/18639 0.0149253731343284 1.5455223880597 0.478650387365613 0.639113653536289 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/180 67/18639 0.0149253731343284 1.5455223880597 0.478650387365613 0.639113653536289 GO:0046982 protein heterodimerization activity 4/180 369/18639 0.010840108401084 1.12249322493225 0.478777675908643 0.639113653536289 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/180 268/18639 0.0111940298507463 1.15914179104478 0.480362313885682 0.639113653536289 GO:0016874 ligase activity 2/180 167/18639 0.0119760479041916 1.24011976047904 0.481010066288318 0.639113653536289 GO:0005096 GTPase activator activity 3/180 271/18639 0.011070110701107 1.14630996309963 0.487719647858484 0.646228533412492 GO:0016782 transferase activity, transferring sulphur-containing groups 1/180 70/18639 0.0142857142857143 1.47928571428571 0.493663519712438 0.652292240728069 GO:0005126 cytokine receptor binding 3/180 275/18639 0.0109090909090909 1.12963636363636 0.497451311667487 0.655481424490032 GO:0042379 chemokine receptor binding 1/180 72/18639 0.0138888888888889 1.43819444444444 0.503432624987518 0.661365202850488 GO:0001217 DNA-binding transcription repressor activity 3/180 278/18639 0.0107913669064748 1.11744604316547 0.504689588758024 0.661365202850488 GO:0005319 lipid transporter activity 2/180 178/18639 0.0112359550561798 1.16348314606742 0.514754066682577 0.672705999472847 GO:0031267 small GTPase binding 3/180 283/18639 0.0106007067137809 1.09770318021201 0.516634166339269 0.673318298753637 GO:0016853 isomerase activity 2/180 180/18639 0.0111111111111111 1.15055555555556 0.520733193264874 0.675744718700746 GO:0051536 iron-sulfur cluster binding 1/180 76/18639 0.0131578947368421 1.3625 0.522412047218876 0.675744718700746 GO:0003712 transcription coregulator activity 5/180 495/18639 0.0101010101010101 1.0459595959596 0.522745914466615 0.675744718700746 GO:0005543 phospholipid binding 5/180 497/18639 0.0100603621730382 1.04175050301811 0.526332081777979 0.675805237604075 GO:0003724 RNA helicase activity 1/180 77/18639 0.012987012987013 1.34480519480519 0.527043078383052 0.675805237604075 GO:0051540 metal cluster binding 1/180 77/18639 0.012987012987013 1.34480519480519 0.527043078383052 0.675805237604075 GO:1901981 phosphatidylinositol phosphate binding 2/180 185/18639 0.0108108108108108 1.11945945945946 0.535465701111272 0.683833823058727 GO:0008186 ATP-dependent activity, acting on RNA 1/180 79/18639 0.0126582278481013 1.31075949367089 0.536171592922356 0.683833823058727 GO:0031406 carboxylic acid binding 2/180 187/18639 0.0106951871657754 1.10748663101604 0.541271768971415 0.68849769013164 GO:0030971 receptor tyrosine kinase binding 1/180 81/18639 0.0123456790123457 1.2783950617284 0.545124878539044 0.691554699635968 GO:0043177 organic acid binding 2/180 189/18639 0.0105820105820106 1.0957671957672 0.547027756918547 0.692127957692698 GO:0005254 chloride channel activity 1/180 83/18639 0.0120481927710843 1.24759036144578 0.553906280456109 0.695298146783063 GO:0008135 translation factor activity, RNA binding 1/180 83/18639 0.0120481927710843 1.24759036144578 0.553906280456109 0.695298146783063 GO:0030165 PDZ domain binding 1/180 83/18639 0.0120481927710843 1.24759036144578 0.553906280456109 0.695298146783063 GO:0051117 ATPase binding 1/180 84/18639 0.0119047619047619 1.2327380952381 0.558233553010426 0.697061269073228 GO:0180051 translation factor activity 1/180 84/18639 0.0119047619047619 1.2327380952381 0.558233553010426 0.697061269073228 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/180 86/18639 0.0116279069767442 1.20406976744186 0.566763263070856 0.705864429464225 GO:0016758 hexosyltransferase activity 2/180 197/18639 0.0101522842639594 1.05126903553299 0.569546723601592 0.707483820723852 GO:0072341 modified amino acid binding 1/180 91/18639 0.010989010989011 1.13791208791209 0.587377757750667 0.727738157005372 GO:0051020 GTPase binding 3/180 315/18639 0.00952380952380952 0.986190476190476 0.589226058350261 0.728136864852525 GO:0016410 N-acyltransferase activity 1/180 94/18639 0.0106382978723404 1.10159574468085 0.599275129887501 0.738641439163665 GO:0004674 protein serine/threonine kinase activity 4/180 433/18639 0.0092378752886836 0.956581986143187 0.604817855710555 0.743551848386429 GO:0005216 monoatomic ion channel activity 4/180 448/18639 0.00892857142857143 0.924553571428571 0.631596256568537 0.774157228927455 GO:0005253 monoatomic anion channel activity 1/180 103/18639 0.00970873786407767 1.00533980582524 0.63295874063251 0.774157228927455 GO:0005261 monoatomic cation channel activity 3/180 341/18639 0.00879765395894428 0.91099706744868 0.642845464707647 0.783093620030995 GO:0004497 monooxygenase activity 1/180 106/18639 0.00943396226415094 0.97688679245283 0.643548635329455 0.783093620030995 GO:0004620 phospholipase activity 1/180 109/18639 0.00917431192660551 0.95 0.653834638429914 0.784951280621441 GO:0005549 odorant binding 1/180 111/18639 0.00900900900900901 0.932882882882883 0.660527438466454 0.784951280621441 GO:0045182 translation regulator activity 3/180 356/18639 0.00842696629213483 0.872612359550562 0.671473988864276 0.784951280621441 GO:0017124 SH3 domain binding 1/180 115/18639 0.00869565217391304 0.900434782608696 0.673529416701943 0.784951280621441 GO:0106310 protein serine kinase activity 3/180 361/18639 0.00831024930747922 0.860526315789474 0.680637934004978 0.784951280621441 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/180 243/18639 0.00823045267489712 0.852263374485597 0.683214333956408 0.784951280621441 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0004711 ribosomal protein S6 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0035175 histone H3S10 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0035979 histone H2AXS139 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0044022 histone H3S28 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0044023 histone H4S1 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0044024 histone H2AS1 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0044025 histone H2BS14 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0072354 histone H3T3 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0072371 histone H2AS121 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0140823 histone H2BS36 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0140855 histone H3S57 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0140995 histone H2A kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0140997 histone H4 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0140998 histone H2B kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:1990244 histone H2AT120 kinase activity 2/180 245/18639 0.00816326530612245 0.84530612244898 0.687554392304045 0.784951280621441 GO:0004677 DNA-dependent protein kinase activity 2/180 246/18639 0.00813008130081301 0.841869918699187 0.689706169312248 0.784951280621441 GO:0140857 histone H3T45 kinase activity 2/180 246/18639 0.00813008130081301 0.841869918699187 0.689706169312248 0.784951280621441 GO:0035402 histone H3T11 kinase activity 2/180 247/18639 0.00809716599190283 0.838461538461538 0.691845820061874 0.784951280621441 GO:0035403 histone H3T6 kinase activity 2/180 247/18639 0.00809716599190283 0.838461538461538 0.691845820061874 0.784951280621441 GO:0015108 chloride transmembrane transporter activity 1/180 121/18639 0.00826446280991736 0.855785123966942 0.692109548778805 0.784951280621441 GO:0004679 AMP-activated protein kinase activity 2/180 248/18639 0.00806451612903226 0.83508064516129 0.693973376602047 0.784951280621441 GO:0008528 G protein-coupled peptide receptor activity 1/180 122/18639 0.00819672131147541 0.848770491803279 0.695102327762486 0.784951280621441 GO:0140104 molecular carrier activity 2/180 249/18639 0.00803212851405622 0.831726907630522 0.696088871494486 0.784951280621441 GO:0030695 GTPase regulator activity 4/180 489/18639 0.0081799591002045 0.847034764826176 0.698692241298749 0.785887863134538 GO:0060589 nucleoside-triphosphatase regulator activity 4/180 490/18639 0.00816326530612245 0.84530612244898 0.700214553107293 0.785887863134538 GO:0042826 histone deacetylase binding 1/180 127/18639 0.0078740157480315 0.815354330708661 0.70963778671145 0.793766480191605 GO:0003713 transcription coactivator activity 2/180 256/18639 0.0078125 0.808984375 0.710562446628544 0.793766480191605 GO:0001653 peptide receptor activity 1/180 128/18639 0.0078125 0.808984375 0.712461101231325 0.794027909549865 GO:0016298 lipase activity 1/180 130/18639 0.00769230769230769 0.796538461538462 0.718026089084027 0.796508010449025 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/180 130/18639 0.00769230769230769 0.796538461538462 0.718026089084027 0.796508010449025 GO:0016757 glycosyltransferase activity 2/180 267/18639 0.00749063670411985 0.77565543071161 0.732145104166026 0.810285880944767 GO:0016779 nucleotidyltransferase activity 1/180 136/18639 0.00735294117647059 0.761397058823529 0.734086512695466 0.810553857767911 GO:0030295 protein kinase activator activity 1/180 139/18639 0.00719424460431655 0.744964028776979 0.741772213746217 0.816983099425379 GO:0016791 phosphatase activity 2/180 273/18639 0.00732600732600733 0.758608058608059 0.743334727779066 0.816983099425379 GO:0022843 voltage-gated monoatomic cation channel activity 1/180 143/18639 0.00699300699300699 0.724125874125874 0.751677225626033 0.824252957755443 GO:0008194 UDP-glycosyltransferase activity 1/180 145/18639 0.00689655172413793 0.714137931034483 0.756487108711153 0.826304735791671 GO:0035091 phosphatidylinositol binding 2/180 284/18639 0.00704225352112676 0.729225352112676 0.762816450712439 0.826304735791671 GO:0019209 kinase activator activity 1/180 148/18639 0.00675675675675676 0.699662162162162 0.763528756902758 0.826304735791671 GO:0008509 monoatomic anion transmembrane transporter activity 1/180 149/18639 0.00671140939597315 0.69496644295302 0.765830678040473 0.826304735791671 GO:0019842 vitamin binding 1/180 150/18639 0.00666666666666667 0.690333333333333 0.768110314490052 0.826304735791671 GO:0000510 H3-H4 histone complex chaperone activity 1/180 151/18639 0.00662251655629139 0.685761589403973 0.770367880793897 0.826304735791671 GO:0140584 chromatin extrusion motor activity 1/180 151/18639 0.00662251655629139 0.685761589403973 0.770367880793897 0.826304735791671 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/180 151/18639 0.00662251655629139 0.685761589403973 0.770367880793897 0.826304735791671 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/180 151/18639 0.00662251655629139 0.685761589403973 0.770367880793897 0.826304735791671 GO:0015616 DNA translocase activity 1/180 152/18639 0.00657894736842105 0.68125 0.77260358944043 0.826304735791671 GO:0140674 ATP-dependent histone chaperone activity 1/180 152/18639 0.00657894736842105 0.68125 0.77260358944043 0.826304735791671 GO:0061775 cohesin loader activity 1/180 153/18639 0.0065359477124183 0.676797385620915 0.774817650883646 0.826818835506709 GO:0004386 helicase activity 1/180 155/18639 0.00645161290322581 0.668064516129032 0.77918166392 0.829619762700536 GO:0140658 ATP-dependent chromatin remodeler activity 1/180 158/18639 0.00632911392405063 0.655379746835443 0.785570475955072 0.834559280691691 GO:0003689 DNA clamp loader activity 1/180 160/18639 0.00625 0.6471875 0.789727219063594 0.83711085220741 GO:0140713 histone chaperone activity 1/180 164/18639 0.00609756097560976 0.63140243902439 0.797801821980175 0.843794831673045 GO:0015103 inorganic anion transmembrane transporter activity 1/180 165/18639 0.00606060606060606 0.627575757575758 0.799771817760611 0.84400698467215 GO:0005244 voltage-gated monoatomic ion channel activity 1/180 173/18639 0.00578034682080925 0.598554913294798 0.814859850526283 0.858025206172288 GO:0003823 antigen binding 1/180 174/18639 0.00574712643678161 0.595114942528736 0.816664530852572 0.858025206172288 GO:0022832 voltage-gated channel activity 1/180 175/18639 0.00571428571428571 0.591714285714286 0.818451716579436 0.858025206172288 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/180 181/18639 0.00552486187845304 0.572099447513812 0.828816776690477 0.866985970353854 GO:0003924 GTPase activity 2/180 331/18639 0.00604229607250755 0.625679758308157 0.832289642943289 0.868713697339057 GO:0140097 catalytic activity, acting on DNA 2/180 336/18639 0.00595238095238095 0.616369047619048 0.83849142187251 0.873115451792558 GO:0140597 protein carrier chaperone 1/180 188/18639 0.00531914893617021 0.550797872340426 0.840167698894726 0.873115451792558 GO:0016829 lyase activity 1/180 200/18639 0.005 0.51775 0.857911756266392 0.889617190737107 GO:0003714 transcription corepressor activity 1/180 204/18639 0.00490196078431373 0.507598039215686 0.863379695127582 0.893345150923767 GO:0008094 ATP-dependent activity, acting on DNA 1/180 210/18639 0.00476190476190476 0.493095238095238 0.871191673705413 0.899477117656888 GO:0015631 tubulin binding 2/180 385/18639 0.00519480519480519 0.537922077922078 0.889154269927681 0.915267795562879 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/180 229/18639 0.00436681222707424 0.452183406113537 0.893115954212097 0.915267795562879 GO:0000287 magnesium ion binding 1/180 230/18639 0.00434782608695652 0.450217391304348 0.894160991053043 0.915267795562879 GO:0005085 guanyl-nucleotide exchange factor activity 1/180 230/18639 0.00434782608695652 0.450217391304348 0.894160991053043 0.915267795562879 GO:0042393 histone binding 1/180 247/18639 0.00404858299595142 0.419230769230769 0.910449283116923 0.929944985110861 GO:0016887 ATP hydrolysis activity 2/180 417/18639 0.00479616306954436 0.496642685851319 0.913855656121473 0.931429803354578 GO:0008017 microtubule binding 1/180 276/18639 0.0036231884057971 0.37518115942029 0.932685901711183 0.947788288635131 GO:0046873 metal ion transmembrane transporter activity 2/180 450/18639 0.00444444444444444 0.460222222222222 0.933879445824972 0.947788288635131 GO:0016755 aminoacyltransferase activity 2/180 496/18639 0.00403225806451613 0.417540322580645 0.954583952593749 0.965635889885791 GO:0022836 gated channel activity 1/180 318/18639 0.00314465408805031 0.32562893081761 0.955513920390133 0.965635889885791 GO:0061630 ubiquitin protein ligase activity 1/180 353/18639 0.0028328611898017 0.293342776203966 0.968522102830279 0.976712564587829 GO:0061659 ubiquitin-like protein ligase activity 1/180 372/18639 0.00268817204301075 0.278360215053763 0.973918202335347 0.980082241590635 GO:0140098 catalytic activity, acting on RNA 1/180 387/18639 0.00258397932816537 0.267571059431525 0.977519689165253 0.981635561540685 GO:0004842 ubiquitin-protein transferase activity 1/180 449/18639 0.0022271714922049 0.230623608017817 0.987852410055108 0.989927730244299 GO:0019787 ubiquitin-like protein transferase activity 1/180 479/18639 0.00208768267223382 0.216179540709812 0.990988094632655 0.990988094632655