category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/826	108/9376	2.6275670343467	UBE2I/NCBP1/NUP58/KPNA2/POM121/ACIN1/RNPS1/NUP214/IPO9/UPF2/NMD3/XPO4/CSE1L/THOC6/RANGAP1/UPF1/SENP2/TNPO3/XPO1/NUP153/SNUPN/NUP37/NCBP2/RANBP17/XPO5	5.28749968496553
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/826	250/9376	1.90698305084746	ZFYVE27/VPS35/RAB4A/RABEP1/VPS25/SNX5/SNX12/ARPC4/EPN2/ZFYVE16/STAMBP/ARFGAP3/RAB5B/CHMP2B/WASHC5/WASHC3/RAB11FIP1/SNX4/CHMP4A/VPS26B/DNM2/WASHC4/AP2A2/GBF1/WASHC1/RAB11FIP2/PIP5K1A/AP2A1/SPART/SNX1/EHD1/STAM/SMAP2/PIP5K1C/DAB2/WASHC2C/RAB7A/STAM2/EPS15L1/ACAP2/AGAP1/ARAP2	4.51774327314796
Genetic Information Processing	Translation	hsa03010	Ribosome	38/826	222/9376	1.9429792989115	RPL13A/RPL3/RPS2/RPLP0/RACK1/RPL18A/MRPS12/MRPS18B/MRPS35/MRPS7/RPL6/MRPL36/MRPS15/MRPL11/RPL26L1/MRPL43/MRPS27/MRPS22/RPL12/MRPS26/MRPL51/DAP3/MRPL37/MRPS31/MRPL18/MRPS5/MRPL24/RPL10A/MRPL38/MRPS2/MRPS25/MRPS9/MRPL1/MRPL40/RPL37A/RPL5/MRPL3/MRPL23	4.41942528925549
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/826	169/9376	2.08215252804562	MAP2K1/CAMKK2/ATG14/VPS41/PRKACA/WDR41/RRAS2/SNAP29/MTMR3/ATG4B/WIPI1/WDR45/NRBF2/BAD/NBR1/RAF1/AKT1/PDPK1/AKT1S1/PIK3C3/GABARAPL1/OPTN/ATG5/MLST8/RAB1A/PIK3CB/TSC2/RAB7A/VPS11/ULK1/ATG4C	4.41230335638004
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/826	116/9376	2.25064707355765	SUCLG1/IDH3G/SUCLA2/H6PD/ME3/GLUD1/MDH1/ACO1/ACOX1/ECHS1/IDH1/SUCLG2/PFKM/RPIA/ADPGK/ACOX3/MCEE/DLST/ADH5/ENO1/TKT/SDSL/PRPS1	4.21260633954463
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/826	174/9376	1.95708441178926	SAR1B/UBE2D1/BAG1/UBE2G1/SEL1L/DNAJB12/GANAB/AMFR/EDEM1/CAPN1/UBXN6/SEC61A1/UBE2J2/CAPN2/XBP1/DDOST/DNAJC5/SEC24D/OS9/SEC24A/CKAP4/UBQLN2/MBTPS2/EDEM2/SEC23B/DNAJC3/MAN1B1/PREB/UBXN4/UBXN2A	3.96074020649704
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/826	32/9376	3.54721549636804	SUCLG1/ECHDC1/SUCLA2/ACOX1/ECHS1/SUCLG2/BCKDHB/ACOX3/MCEE/ACACA	4.48607848020087
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/826	78/9376	2.47395542310797	INPP4B/MTMR3/PPIP5K2/PLCD3/PIKFYVE/ITPK1/INPP4A/PI4KB/IP6K1/PIK3C3/PIP5K1A/PI4KA/PIK3CB/PIP5K1C/IPMK/INPP5B/PI4K2A	4.06283779858068
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/826	157/9376	1.95209820946623	MAP2K1/RRAS2/CDK6/E2F3/CDK4/HUS1/CAPN1/PPP3CB/PPP3CC/CAPN2/RAD9A/RAF1/AKT1/ITPR3/SIRT1/MCU/SLC25A4/ATR/TRPM7/TP53/RAD50/PIK3CB/TSC2/TRAF3IP2/NFATC3/BTRC/RAD1	3.73923079385706
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/826	48/9376	2.83777239709443	ALDH9A1/HADHB/HMGCS1/AUH/ECHS1/IVD/BCKDHB/HIBADH/MCEE/AOX1/ACAA2/ACAD8	3.96744284218405
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/826	30/9376	3.40532687651332	SUCLG1/IDH3G/SUCLA2/MDH1/ACO1/ACLY/IDH1/SUCLG2/DLST	4.10123304068685
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/826	368/9376	1.54226760711654	MT-CO3/ACTG1/PSMC2/ATG14/DCTN3/NDUFA5/NCBP1/PSMC3/NUP58/MT-ATP8/WDR41/NDUFA9/POM121/NDUFB1/PPP3CB/WIPI1/PPP3CC/TUBA1C/XBP1/CHMP2B/NDUFS1/PSMA5/NUP214/NRBF2/BAD/NDUFV3/DCTN1/ITPR3/CASP3/MT-CO1/MCU/NDUFA10/UBQLN2/ATP5MC3/PIK3C3/OPTN/PSMD14/DCTN2/RAB1A/TP53/SPG11/ATP5F1A/PSMD12/TOMM40/NUP153/NUP37/CHCHD10/DCTN5/ACTR1B/ULK1	3.29849619387537
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/826	33/9376	3.0957517059212	STX16/SNAP29/VTI1B/STX4/STX8/BET1/STX5/STX11/SEC22B	3.74840258193596
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/826	204/9376	1.72492047666524	TIMP3/COL1A1/ACTG1/COL1A2/MAP2K1/ARHGEF1/FRS2/EZR/PLAUR/PRKACA/RRAS2/NUDT16L1/DDX5/PPP1R12B/PPP1R12C/RAF1/AKT1/ITPR3/CASP3/PDPK1/TIAM1/WNT4/TP53/DCN/PAK1/CD44/PIK3CB/VEGFA/PTPN11/DROSHA/SDC2	3.25361403292054
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/826	98/9376	2.08489400602856	INPP4B/MTMR3/PPIP5K2/PLCD3/PIKFYVE/ITPR3/ITPK1/INPP4A/PI4KB/IP6K1/PIK3C3/PIP5K1A/PI4KA/PIK3CB/PIP5K1C/IPMK/INPP5B/PI4K2A	3.35556586643321
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/826	117/9376	1.94035719459448	ACTG1/BAZ1B/ACTL6A/BICRAL/SMARCC2/MTA3/EP400/PHF10/ACTR6/RUVBL2/RBBP7/MBD3/TRRAP/GATAD2B/INO80E/SMARCC1/UCHL5/DMAP1/BRD8/CHD3	3.18123934418041
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/826	78/9376	2.18290184391879	BTG3/LSM4/DDX6/CNOT1/PARN/EXOSC1/DCP2/MPHOSPH6/PFKM/CNOT6/CNOT6L/MTREX/ENO1/CNOT3/CNOT2	3.26057236748063
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/826	31/9376	2.92931344216199	SRPRB/SRP72/SRP54/SEC61A1/SGTA/UBL4A/SRPRA/SRP68	3.34415646430401
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/826	122/9376	1.86083435875045	ACTG1/MAP2K1/PRKACA/PLCD3/BAD/RAF1/AKT1/THRA/PDPK1/MED1/WNT4/TP53/PFKM/NCOR1/PIK3CB/NCOA3/TSC2/RXRA/RCAN1/SLC2A1	2.97459172231025
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	41/826	308/9376	1.51102166598535	TGM2/MT-CO3/PSMC2/ATG14/DCTN3/NDUFA5/PSMC3/CREB3L2/SOD2/MT-ATP8/NDUFA9/POLR2A/NDUFB1/WIPI1/TUBA1C/NDUFS1/PSMA5/NRBF2/NDUFV3/DCTN1/CREB3/CASP3/IFT57/AP2A2/MT-CO1/NDUFA10/ATP5MC3/PIK3C3/SLC25A4/PSMD14/AP2A1/POLR2J3/DCTN2/TP53/ATP5F1A/PSMD12/PPIF/DCTN5/RCOR1/ACTR1B/ULK1	2.83433722392111
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/826	90/9376	2.01797148237826	CAMKK2/CREB3L2/PRKACA/SOD2/EIF4E2/AKT1/CREB3/SIRT1/AKT1S1/EHMT1/ATG5/TP53/PIK3CB/TSC2/ADCY9/ULK1	3.01602634879272
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	34/826	250/9376	1.54374818401937	CTSK/IDS/VPS41/VPS35/M6PR/SNAP29/OSBP/SLC36A4/AP3D1/PIKFYVE/VPS26B/DMXL1/AP2A2/AKT1S1/GGA2/DNASE2/ARL8B/AP2A1/MLST8/BORCS8/SPG11/ATP6V0A1/OSBPL5/BLOC1S5/BORCS5/RAB7A/VPS11/AP1B1/IDUA/GAA/BLOC1S4/SLC15A3/CLCN7/MEAK7	2.7084460931708
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/826	70/9376	2.10805949498443	MAP2K1/PAK3/FLCN/BAD/RAF1/EGLN1/AKT1/ARNT/PAK1/PIK3CB/VEGFA/PTPN11/SLC2A1	2.89216575816297
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	48/826	388/9376	1.40425850577869	APOE/MT-CO3/CSNK2A2/PSMC2/MAP2K1/ATG14/NDUFA5/PSMC3/MT-ATP8/NDUFA9/CAPN1/NDUFB1/PPP3CB/WIPI1/PPP3CC/TUBA1C/CAPN2/XBP1/NDUFS1/PSMA5/NRBF2/BAD/NDUFV3/RAF1/AKT1/ITPR3/CASP3/IKBKB/MT-CO1/MCU/NDUFA10/ATP5MC3/PIK3C3/SLC25A4/WNT4/PSMD14/PIK3CB/BACE1/SLC39A6/ATP5F1A/PSMD12/DVL3/SLC39A11/PPIF/SLC39A14/SLC39A13/RTN3/ULK1	2.52776154053232
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	33/826	248/9376	1.51042724361478	ACTG1/MAP2K1/VPS41/DCTN3/M6PR/PAK3/ARPC4/STX10/PLEKHM2/TUBA1C/TXN2/RAB5B/DYNLT3/DCTN1/RAF1/AKT1/DNM2/CASP3/IKBKB/CSE1L/TRADD/RAB9A/PIK3C3/ARL8B/RIPK1/DCTN2/PAK1/PIK3CB/TAB3/RAB7A/VPS11/DCTN5/ACTR1B	2.53200451419577
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/826	43/9376	2.37580944873022	ALDH9A1/HADHB/ACOX1/ECHS1/ECI2/ACADVL/ACOX3/ADH5/ACAA2	2.81044109453974
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	21/826	142/9376	1.67868226306995	UBE2D1/UBE2I/UBE2F/DDB1/UBE2G1/CUL5/UBE2S/FANCL/UBE2J2/UBA2/UBE2K/UBE2R2/TRIM37/PIAS2/FBXW8/PIAS4/MGRN1/UBE2O/PIAS1/FZR1/BTRC	2.53284341013482
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/826	44/9376	2.3218137794409	TAF9/GTF2F2/TAF7/TAF12/CDK7/MNAT1/GTF2A1/GTF2F1/TAF15	2.73150407404596
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/826	44/9376	2.3218137794409	CREB3L2/PRKACA/STX4/RAB5B/DCTN1/CREB3/DCTN2/ADCY9/DCTN5	2.73150407404596
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/826	75/9376	1.96752219531881	MAT2B/IDH3G/MAT2A/ASL/ACO1/ASS1/IDH1/PFKM/RPIA/ENO1/TKT/SDSL/PRPS1	2.61468485108806
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/826	227/9376	1.50014399846402	MAP2K1/ARHGEF1/IRF3/CXCL12/CREB3L2/PRKACA/CDK6/E2F3/CDK4/PPP3CB/PPP3CC/RAF1/AKT1/ITPR3/CREB3/CASP3/IKBKB/TRADD/RIPK1/TP53/PIK3CB/VEGFA/CCL5/TSC2/ADCY9/AKAP13/NFATC3/GNB5/ARHGEF11/CCL4L2	2.37090297221748
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/826	77/9376	1.91641772271312	MAP2K1/CDK6/E2F3/CDK4/STAT5B/BAD/RAF1/AKT1/IKBKB/TP53/PIK3CB/PTPN11/CTBP1	2.5096509501978
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/826	103/9376	1.76327605256353	WDR82/NCBP1/ACIN1/RNPS1/PCF11/UPF2/MSI2/GSPT1/SYMPK/CPSF7/SMG6/UPF1/CPSF2/NCBP2/SMG1/CPSF4	2.42093274009681
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	34/826	268/9376	1.44006360449568	MT-CO3/PSMC2/UBE2G1/NDUFA5/PSMC3/MFN1/PRKACA/MT-ATP8/NDUFA9/NDUFB1/UBE2J2/TUBA1C/TXN2/XBP1/NDUFS1/PSMA5/NDUFV3/ITPR3/CASP3/MT-CO1/MCU/NDUFA10/ATP5MC3/SLC25A4/PSMD14/TP53/SLC39A6/ATP5F1A/PSMD12/SLC39A11/PPIF/SLC39A14/SLC39A13/MAOB	2.27176781386047
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/826	32/9376	2.48305084745763	ATG4B/WIPI1/PIK3C3/GABARAPL1/ATG5/MLST8/ATG4C	2.61190405810174
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/826	63/9376	1.98193627733579	ALDH9A1/PLOD3/ECHS1/SETD1A/EZH1/EHMT1/PLOD1/SETD2/CAMKMT/NSD1/DLST	2.43053222187718
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/826	105/9376	1.72968984203851	CSNK2A2/AMFR/MFN1/RRAS2/RAB5B/NBR1/GABARAPL1/OPTN/RHOT1/TP53/TOMM70/TOMM40/MTX1/RAB7A/BNIP3L/ULK1	2.33701911180449
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/826	73/9376	1.86593253507579	MAP2K1/CDK6/E2F3/CDK4/STAT5B/BAD/RAF1/AKT1/PDPK1/TP53/PIK3CB/RXRA	2.30848247258521
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/826	83/9376	1.7778815017941	GSTK1/SOD2/ACOX1/IDH1/PHYH/PMVK/ECI2/CRAT/ACOX3/CROT/PEX11B/PEX3/PEX26	2.21241770916629
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/826	137/9376	1.57423870203779	ACTG1/CTSK/MAP2K1/CAPN1/TUBA1C/CAPN2/BAD/RAF1/AKT1/ITPR3/CASP3/IKBKB/PDPK1/CASP10/TRADD/RIPK1/TP53/BCL2L11/PIK3CB	2.10442214791652
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/826	93/9376	1.7087661745945	CKS2/LAMA2/CDK6/E2F3/CDK4/CKS1B/TRAF3/AKT1/CASP3/IKBKB/TP53/PIK3CB/RXRA/LAMC1	2.13497545512904
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/826	203/9376	1.45383413447202	COL1A1/COL6A3/ACTG1/COL1A2/MAP2K1/COL6A1/ZYX/LAMA2/PAK3/CAPN2/PPP1R12B/BAD/PPP1R12C/RAF1/AKT1/PDPK1/ARHGAP35/PIP5K1A/ARHGAP5/PAK1/PIK3CB/VEGFA/PIP5K1C/VEGFB/LAMC1/VEGFC	2.0318052787002
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/826	60/9376	1.89184826472962	MAP2K1/PPP3CB/PPP3CC/BAD/RAF1/AKT1/PIK3CB/VEGFA/PLA2G4C/HSPB1	2.15399386199585
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	33/826	275/9376	1.36213075060533	MT-CO3/CSNK2A2/PSMC2/NDUFA5/PSMC3/CREB3L2/PRKACA/MT-ATP8/NDUFA9/STIP1/NDUFB1/PPP3CB/PPP3CC/TUBA1C/NDUFS1/PSMA5/BAD/NDUFV3/ITPR3/CREB3/CASP3/MT-CO1/MCU/NDUFA10/ATP5MC3/SLC25A4/PSMD14/PIK3CB/CCL5/ATP5F1A/PSMD12/PPIF/LAMC1	1.89443539378345
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/826	54/9376	1.89184826472962	MAT2B/MAT2A/DNMT1/AMD1/KYAT3/MDH1/MTAP/AHCYL2/SDSL	2.04280027079674
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/826	71/9376	1.75861951369232	MAP2K1/SLC1A5/RAF1/AKT1/SLC16A3/IDH1/TP53/PFKM/PIK3CB/SCO2/SLC2A1	1.99428673168231
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/826	23/9376	2.46762817138646	HMGCS1/PMVK/DHDDS/PCYOX1/MVD	2.19026717657789
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/826	144/9376	1.49771320957762	ALDH9A1/IRF3/CAMKK2/LPIN1/C3/TRAF3/AKT1/ACOX1/CASP3/IKBKB/SIRT1/TRADD/IL17RA/RIPK1/TAB3/ACADVL/ACOX3/ADH5/ACACA	1.87070419417181
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/826	144/9376	1.49771320957762	RORA/PSMC2/ATG14/PSMC3/WIPI1/XBP1/PSMA5/NRBF2/AKT1/ITPR3/MCU/PIK3C3/NOP56/SLC25A4/PSMD14/PIK3CB/PSMD12/PPIF/ULK1	1.87070419417181
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	53/826	480/9376	1.25334947538337	MT-CO3/CSNK2A2/PSMC2/MAP2K1/ATG14/DCTN3/UBE2G1/NDUFA5/PSMC3/MFN1/MT-ATP8/WDR41/NDUFA9/CAPN1/NDUFB1/PPP3CB/UBE2J2/WIPI1/PPP3CC/TUBA1C/CAPN2/XBP1/CHMP2B/NDUFS1/PSMA5/NRBF2/BAD/NDUFV3/DCTN1/RAF1/ITPR3/CASP3/IFT57/MT-CO1/MCU/NDUFA10/ATP5MC3/PIK3C3/OPTN/SLC25A4/WNT4/PSMD14/DCTN2/RAB1A/SPG11/ATP5F1A/PSMD12/DVL3/TOMM40/PPIF/DCTN5/ACTR1B/ULK1	1.7710704842596
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/826	31/9376	2.1969850816215	DERA/H6PD/PFKM/RPIA/TKT/PRPS1	2.07478230903441
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/826	73/9376	1.71043815715281	MAP2K1/FGF10/CDK6/E2F3/CDK4/BAD/RAF1/AKT1/TP53/PIK3CB/FGF7	1.89395128051107
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/826	56/9376	1.82428225527499	PRKACA/KIF3A/CSNK1G2/CSNK1D/GAS1/DISP1/MGRN1/CSNK1G1/BTRC	1.92289075981495
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/826	101/9376	1.57341835878503	COL3A1/COL1A1/COL1A2/CDK4/STAT5B/PLCD3/F3/PIM1/AKT1/CASP3/PIK3CB/VEGFA/VEGFB/VEGFC	1.80081013250907
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/826	196/9376	1.38992933735237	MAP2K1/IRF3/ATG14/CDK6/E2F3/CDK4/PPP3CB/PPP3CC/C3/TRAF3/RAF1/AKT1/ITPR3/CASP3/IKBKB/TRADD/PIK3C3/TP53/PIK3CB/VEGFA/RCAN1/NFATC3/GNB5/LYN	1.71468840569921
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	20/826	158/9376	1.43684678333895	MAP2K1/WDR59/FLCN/LPIN1/EIF4E2/RAF1/AKT1/IKBKB/PDPK1/CLIP1/AKT1S1/WNT4/MLST8/PIK3CB/DVL3/RICTOR/TSC2/DEPDC5/MIOS/ULK1	1.72120238133747
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/826	75/9376	1.66482647296207	REV3L/TOP2B/BAD/AKT1/CASP3/PDPK1/GSTM3/TP53/PIK3CB/MSH3/MSH2	1.79666339011834
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/826	42/9376	1.89184826472962	ALDH9A1/KYAT3/ECHS1/DLST/AFMID/AOX1/MAOB	1.80042204961089
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/826	77/9376	1.6215842269111	MAP2K1/CDK6/E2F3/CDK4/BAD/RAF1/AKT1/IKBKB/TP53/PIK3CB/VEGFA	1.70223622593967
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/826	34/9376	2.00313345677254	POLR2A/POLR2M/POLR2J3/CRCP/POLR3E/POLR1C	1.82125537668822
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/826	12/9376	2.83777239709443	GGCX/VKORC1L1/COQ4	1.9799045297334
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/826	235/9376	1.30416773994127	MT-CO3/ACTG1/NDUFA5/FRS2/CREB3L2/PRKACA/MT-ATP8/ACTL6A/NDUFA9/SMARCC2/NDUFB1/NDUFAF6/NDUFS1/NDUFV3/CREB3/AKT1S1/CNR1/MT-CO1/NDUFA10/ATP5MC3/SMARCC1/MLST8/ATP5F1A/TSC2/ADCY9/KDM3B/COX15	1.46771871505374
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/826	62/9376	1.64773881121612	PRKACA/SOD2/EIF4EBP2/AKT1/SIRT1/AKT1S1/ATG5/PIK3CB/ADCY9	1.59045084916219
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/826	99/9376	1.49054711766576	MAP2K1/PRKACA/E2F3/CDK4/BAD/RAF1/AKT1/MED1/TP53/NCOR1/PIK3CB/NCOA3/ADCY9	1.52506077747239
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/826	227/9376	1.30012479866881	MT-CO3/MAP2K1/NDUFA5/SOD2/MT-ATP8/NDUFA9/NDUFB1/NDUFS1/BAD/NDUFV3/RAF1/AKT1/IKBKB/PDPK1/GSTM3/CBR1/MT-CO1/NDUFA10/ARNT/ATP5MC3/SLC25A4/PIK3CB/VEGFA/ATP5F1A/PPIF/PTPN11	1.42272381431217
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/826	119/9376	1.43080961198039	MAP2K1/CREB3L2/TRAF3/AKT1/CREB3/CASP3/IKBKB/CASP10/TRADD/IL15/RIPK1/PIK3CB/TAB3/CCL5/VEGFC	1.46999662551492
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/826	37/9376	1.84071723054774	NANS/UGP2/GFPT1/GALK1/GALK2/UXS1	1.5925505530329
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/826	46/9376	1.72733971997052	PSMC2/PSMC3/PSMA5/PSMB8/PSMD14/PSME2/PSMD12	1.53697924692118
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/826	21/9376	2.16211230254814	B4GALT7/B3GAT3/CHST3/CHST14	1.65702268771316
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/826	57/9376	1.59313538082494	HADHB/ACOX1/ECHS1/ACADVL/ACOX3/ACACA/ACAA2/ELOVL5	1.39604432376683
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/826	224/9376	1.2668626772743	MAP2K1/CREB3L2/PRKACA/E2F3/CDK4/PPP3CB/PPP3CC/STAT5B/AKT1/CREB3/IKBKB/IL15/TRRAP/TCF3/SLC25A4/ATR/TP53/CRTC1/PIK3CB/XPO1/ADCY9/NFATC3/RANBP3/SLC2A1/SRF	1.25645357584326
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/826	214/9376	1.27301939308909	MAP2K1/IRF3/DDB1/CUL5/PAK3/PPP3CB/PPP3CC/BAD/RAF1/AKT1/ITPR3/CASP3/IKBKB/TRADD/ATR/RIPK1/PAK1/SAMHD1/PIK3CB/AP1B1/NFATC3/GNB5/BTRC/LIMK1	1.25573455247402
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/826	115/9376	1.38187177597642	OXSR1/MAP2K1/ARHGEF1/CREB3L2/PRKACA/NACA/RAF1/ITPR3/CREB3/PDE4B/RXRA/ADCY9/AKAP13/ARHGEF11	1.28064908505995
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/826	205/9376	1.27353688064726	PSMC2/IRF3/PSMC3/CDK6/E2F3/CDK4/TRAF3/AKT1/CASP3/IKBKB/SNW1/TRADD/NCOR2/PSMD14/RIPK1/TP53/BCL2L11/CD44/PIK3CB/SAP30/PSMD12/SAP30L/LYN	1.2307705002939
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/826	106/9376	1.39211476083878	ZEB1/MAP2K1/AR/CREB3L2/E2F3/BAD/RAF1/AKT1/CREB3/IKBKB/PDPK1/TP53/PIK3CB	1.26188233670211
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/826	136/9376	1.33542230451503	RACK1/CSNK2A2/IRF3/CDK6/CDK4/STAT5B/TRAF3/EIF3H/BAD/AKT1/CASP3/IKBKB/TRADD/RAB9A/TP53/PIK3CB	1.22466698884344
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/826	156/9376	1.30974110635128	MAP2K1/IRF3/CDK6/E2F3/CDK4/CLDN4/TRAF3/BAD/RAF1/AKT1/CASP3/IKBKB/TRADD/RIPK1/TP53/PIK3CB/RXRA/PIAS1	1.21251826221197
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/826	32/9376	1.77360774818402	B4GALT1/UGP2/GALK1/PFKM/GAA	1.36245444336899
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/826	50/9376	1.58915254237288	ALDH9A1/SAT2/AMD1/OAT/P4HA2/CKB/MAOB	1.29824798510914
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/826	41/9376	1.66113506171381	MAP2K1/E2F3/CDK4/RAF1/TP53/VEGFA	1.31861363208571
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/826	98/9376	1.38992933735237	MAP2K1/ARPC4/RAF1/AKT1/DNM2/PIP5K1A/PAK1/PIK3CB/PLA2G4C/PIP5K1C/LYN/LIMK1	1.20604738109881
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/826	178/9376	1.27540332453682	SFRP2/CSNK2A2/PRKACA/CBY1/PPP3CB/PPP3CC/DAAM1/CTNNBIP1/SIRT1/WNT4/TP53/SENP2/DVL3/LZTS2/NFATC3/BTRC/TLE2/CTBP1/SFRP1/SERPINF1	1.1529887812829
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/826	168/9376	1.28375417963796	IFNGR2/STAT6/SOCS6/CSH1/STAT5B/PIM1/RAF1/AKT1/IL15/STAM/PIAS2/PIK3CB/SOCS2/PIAS4/PIAS1/PTPN11/STAM2/AOX1/PRLR	1.15347147059518
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/826	33/9376	1.71986205884511	IDH3G/ACO1/IDH1/BCKDHB/DLST	1.28752504048502
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/826	42/9376	1.6215842269111	SAT2/FTL/SLC40A1/ATG5/TP53/SLC39A14	1.25482550348446
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/826	90/9376	1.38735539413506	CSNK2A2/MAP2K1/IFNGR2/PPP3CB/PPP3CC/RAF1/AKT1/IKBKB/PIK3CB/PTPN11/NFATC3	1.14764911913731
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/826	110/9376	1.34149240589919	MAP2K1/IFNGR2/EIF4E2/MKNK1/EGLN1/AKT1/ARNT/PFKM/PIK3CB/VEGFA/PFKFB3/SLC2A1/ENO1	1.11975716341571
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/826	232/9376	1.22317775736829	TMSB4X/ACTG1/MAP2K1/ARHGEF1/CXCL12/FGF10/EZR/RRAS2/PAK3/ARPC4/PPP1R12B/BAIAP2/PIKFYVE/PPP1R12C/RAF1/AKT1/ARHGAP35/TIAM1/PIP5K1A/PAK1/PIK3CB/PIP5K1C/FGF7/ENAH/LIMK1	1.06984139391602
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/826	130/9376	1.30974110635128	COL3A1/COL1A1/COL1A2/MAP2K1/CREB3L2/PRKACA/RAF1/AKT1/CREB3/PIK3CB/VEGFA/VEGFB/ADCY9/VEGFC/GNB5	1.10531529923043
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/826	71/9376	1.43887051120281	MAP2K1/CGA/SOCS6/STAT5B/RAF1/AKT1/PIK3CB/SOCS2/PRLR	1.15371885592356
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/826	17/9376	2.00313345677254	PAPSS1/KYAT3/SEPHS2	1.28665187405235
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/826	122/9376	1.30258405112531	CAMKK2/CREB3L2/AKT1/CREB3/PDPK1/SIRT1/AKT1S1/EEF2/PFKM/PIK3CB/TSC2/PFKFB3/ACACA/ULK1	1.04557166501457
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/826	173/9376	1.2466514576831	ACTG1/MAP2K1/IRF3/IFNGR2/KPNA2/CDK6/CDK4/TRAF3/RAF1/AKT1/CASP3/IKBKB/TRADD/SLC25A4/PIK3CB/CCL5/DNAJC3/XPO1/CPSF4	1.01773481553614
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/826	44/9376	1.5478758529606	MGAT2/B4GALT1/DDOST/MAN1B1/ALG9/ALG1	1.13217546049965
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/826	63/9376	1.44140820169876	DDB1/POLR2A/POLR2M/CDK7/MNAT1/POLR2J3/POLD2/CETN2	1.0925931570026
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/826	163/9376	1.25349455577177	MAP2K1/IRF3/DDB1/STAT6/CREB3L2/E2F3/STAT5B/TRAF3/BAD/RAF1/AKT1/CREB3/CASP3/IKBKB/CASP10/TP53/PIK3CB/NFATC3	1.01473936334421
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/826	26/9376	1.74632147513503	ACOX1/PLAAT3/PLA2G4C/ACOX3	1.18440276208566
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/826	83/9376	1.36760115522623	UBE2D1/PHC2/USP16/FOXK2/RBBP7/EZH1/PCGF6/PHC3/AEBP2/SCMH1	1.04551567797504
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/826	83/9376	1.36760115522623	IRF3/CASP3/IKBKB/DNASE2/RIPK1/SAMHD1/CCL5/CCL4L2/POLR3E/POLR1C	1.04551567797504
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/826	154/9376	1.25304235715858	ACTG1/MAP2K1/CAMKK2/PRKACA/PPP3CB/PPP3CC/PPP1R12B/PPP1R12C/RAF1/ITPR3/CACNB2/EEF2/CAMK1/PLA2G4C/RCAN1/ADCY9/NFATC3	0.984087307599446
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/826	105/9376	1.29726738152888	RRAS2/PPP3CB/PPP3CC/RAF1/AKT1/ITPR3/IKBKB/PAK1/PIK3CB/FCER1G/PTPN11/NFATC3	0.952075131001223
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/826	75/9376	1.36213075060533	CDK6/CDK4/CD82/CASP3/ATR/TP53/CCNG2/MDM4/TSC2	0.978641929148614
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/826	10/9376	2.27021791767555	PAPSS1/BPNT1	1.24909008883264
Organismal Systems	Immune system	hsa04611	Platelet activation	14/826	126/9376	1.26123217648641	COL3A1/COL1A1/ACTG1/COL1A2/ARHGEF1/PRKACA/AKT1/ITPR3/ARHGAP35/PIK3CB/PLA2G4C/FCER1G/ADCY9/LYN	0.917558324103128
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/826	56/9376	1.41888619854722	GANAB/MGAT2/B4GALT1/DDOST/MAN1B1/ALG9/ALG1	0.977180323179148
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/826	37/9376	1.53393102545645	ASL/GLUD1/ASS1/GFPT1/NIT2	1.01141277825138
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/826	37/9376	1.53393102545645	FAHD1/GSTZ1/ADH5/AOX1/MAOB	1.01141277825138
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/826	76/9376	1.34420797757105	MAP2K1/CDK6/E2F3/CDK4/RAF1/AKT1/CAMK1/TP53/PIK3CB	0.936437631691964
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/826	28/9376	1.6215842269111	HADHB/ECHS1/ACAA2/ELOVL5	1.02379323085999
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/826	107/9376	1.27301939308909	CREB3L2/PRKACA/PPP4R3A/PPP3CB/PPP3CC/AKT1/ITPR3/CREB3/SIRT1/PFKM/SLC2A1/ACACA	0.882798423976684
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/826	138/9376	1.23381408569323	MAP2K1/PRKACA/PRKAR2A/BAD/EIF4E2/MKNK1/RAF1/AKT1/IKBKB/PDPK1/SORBS1/PIK3CB/SOCS2/TSC2/ACACA	0.860030472951302
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/826	87/9376	1.30472294119284	MAP2K1/BAD/RAF1/AKT1/CASP3/TP53/BCL2L11/PIK3CB/MSH3/MSH2	0.887509275966214
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/826	243/9376	1.16780757082075	ZMAT2/WBP11/SNRPD1/SLU7/LSM4/CDC5L/NCBP1/SNRNP200/SRSF6/ACIN1/PHF5A/SART1/DDX5/SNRPA/SNW1/USP39/THOC6/DHX8/SNIP1/PLRG1/NCBP2/EFTUD2/HNRNPC/RBM25/PPIH	0.823759740784962
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/826	38/9376	1.49356441952338	UGP2/GFPT1/GALK1/GALK2/UXS1	0.947548203133019
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/826	38/9376	1.49356441952338	NT5C/SIRT1/SIRT7/NADK/AOX1	0.947548203133019
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/826	68/9376	1.33542230451503	MAP2K1/STAT5B/BAD/PIM1/RAF1/AKT1/IKBKB/PIK3CB	0.862801342079334
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/826	20/9376	1.70266343825666	NANS/CYB5R4/UGP2	0.977709538584443
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/826	120/9376	1.22970137207425	MAP2K1/FRS2/BAD/RAF1/AKT1/IKBKB/PDPK1/MAGED1/TP53/PIK3CB/KIDINS220/PTPN11/ZNF274	0.787109481486533
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/826	69/9376	1.31606835807278	MAP2K1/RAF1/AKT1/PDPK1/PIK3CB/PLA2G4C/FCER1G/LYN	0.819017748556778
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/826	49/9376	1.38992933735237	GALNT13/B4GALT1/PLOD3/RFNG/XXYLT1/GALNT11	0.850561200356165
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/826	59/9376	1.34673944268888	CGA/PRKACA/AKT1/PLAAT3/ABHD5/PIK3CB/ADCY9	0.830393248293043
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/826	59/9376	1.34673944268888	MAP2K1/BAD/RAF1/AKT1/PDPK1/TP53/PIK3CB	0.830393248293043
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/826	205/9376	1.16279454319967	MRPS18B/IRF3/DDB1/CREB3L2/PRKACA/CDK6/CDK4/C3/STAT5B/TRAF3/BAD/CREB3/CASP3/SNW1/TRADD/GTF2A1/TP53/PIK3CB/HDAC4/LYN/SRF	0.732488872816217
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/826	205/9376	1.16279454319967	COL3A1/MT-CO3/COL1A1/COL1A2/NDUFA5/MT-ATP8/NDUFA9/MPC1/NDUFB1/NDUFS1/NDUFV3/AKT1/MT-CO1/NDUFA10/ATP5MC3/GFPT1/SLC25A4/PIK3CB/ATP5F1A/PPIF/SLC2A1	0.732488872816217
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/826	184/9376	1.17212338140857	SEMA5A/CXCL12/PAK3/RASA1/PPP3CB/PPP3CC/RAF1/PDPK1/WNT4/PAK1/PIK3CB/TRPC4/TRPC6/PTPN11/NFATC3/NTN4/ENAH/LRIG2/LIMK1	0.732885918741485
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/826	30/9376	1.5134786117837	PIGP/PIGL/PIGU/PIGM	0.875513207330036
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/826	80/9376	1.27699757869249	MAP2K1/BAD/EIF4E2/RAF1/AKT1/BCL2L11/PIK3CB/VEGFA/GAS6	0.773331166440935
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/826	122/9376	1.20954233318779	MAP2K1/PAK3/CDK4/PPP3CB/PPP3CC/RAF1/AKT1/IKBKB/PDPK1/PAK1/PIK3CB/PTPN11/NFATC3	0.724068322131961
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/826	91/9376	1.24737248223931	MAP2K1/PPP3CB/PPP3CC/RAF1/AKT1/IKBKB/LILRB1/PIK3CB/NFATC3/LYN	0.737010599131304
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/826	31/9376	1.464656721081	ALDH9A1/ACOX1/ECHS1/ACOX3	0.805408153764809
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/826	31/9376	1.464656721081	MDH1/ACO1/MCEE/AFMID	0.805408153764809
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/826	51/9376	1.33542230451503	ACTG1/PRKACA/SEC61A1/KDELR3/ATP6V0A1/ADCY9	0.746526468938131
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/826	103/9376	1.21225228613743	COL3A1/COL1A1/COL1A2/LAMA2/PRKACA/RAB5B/CASP3/PIK3CB/HSPB1/RAB7A/LAMC1	0.673214503382738
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/826	72/9376	1.26123217648641	IRF3/AZI2/TRAF3/IKBKB/CASP10/TRADD/ATG5/RIPK1	0.691593130226252
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	25/826	253/9376	1.12164916881203	ACTG1/UBE2D1/IRF3/ATG14/TNIP1/ARPC4/CAPN1/WIPI1/CAPN2/C3/PLCD3/AKT1/ITPR3/IKBKB/AKT1S1/TRADD/PIK3C3/ATG5/RIPK1/TP53/CD44/PIK3CB/TAB3/CCL5/BTRC	0.60966768131801
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/826	62/9376	1.28157463094587	MAML1/SNW1/NCOR2/RFNG/DVL3/TLE2/CTBP1	0.691375293769408
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/826	22/9376	1.5478758529606	ALDH9A1/CARNMT1/MAOB	0.799626948345186
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/826	157/9376	1.15679893894295	MT-CO3/MLXIP/NDUFA5/NDUFA9/NDUFB1/XBP1/NDUFS1/NDUFV3/AKT1/CASP3/IKBKB/MT-CO1/NDUFA10/BCL2L11/PIK3CB/RXRA	0.615805612394018
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	20/826	200/9376	1.13510895883777	ACTG1/ARHGEF1/EZR/PAK3/ARPC4/TUBA1C/CLDN4/SEC24D/BAIAP2/CASP3/IKBKB/SEC24A/TRADD/ABCF2/RIPK1/RAB1A/PAK1/TAB3/PTPN11/ARHGEF11	0.600295443880988
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/826	73/9376	1.24395502338386	CHMP4A/CCNT1/CPSF7/TNPO3/SAMHD1/SUPT5H/XPO1/NUP153	0.650357704288666
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/826	105/9376	1.18916176640148	CSNK2A2/UBE2I/CXCL12/TRAF3/IKBKB/TRADD/RIPK1/TAB3/PIAS4/CCL4L2/LYN	0.605839135800406
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/826	13/9376	1.74632147513503	RAD50/XRCC4	0.836917612438346
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/826	180/9376	1.13510895883777	IRF3/IFNGR2/EIF2B1/SRSF6/C3/TRAF3/BAD/SRPK1/AKT1/CASP3/IKBKB/TRADD/TNFRSF14/TP53/PIK3CB/CCL5/TSC2/PTPN11	0.568870644021068
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/826	53/9376	1.28502901000503	PRKACA/DNM2/AP2A2/AP2A1/ADCY9/SLC8A1	0.646757928786923
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/826	333/9376	1.09079539588014	COL1A1/COL6A3/COL1A2/MAP2K1/COL6A1/IRF3/LAMA2/CREB3L2/PRKACA/CDK6/MAML1/CDK4/TADA3/TRAF3/BAD/RAF1/AKT1/CREB3/CASP3/IKBKB/TRADD/WNT4/ATR/TP53/RFNG/PIK3CB/VEGFA/NFX1/ATP6V0A1/DVL3/TSC2/LAMC1	0.524351219487333
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/826	170/9376	1.13510895883777	ACTG1/MAP2K1/ACTL6A/CDK6/E2F3/CDK4/SMARCC2/PHF10/BAD/RAF1/AKT1/GSTM3/SMARCC1/WNT4/TP53/PIK3CB/DVL3	0.552542549424319
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/826	138/9376	1.15155981331368	MT-CO3/NDUFA5/MT-ATP8/NDUFA9/NDUFB1/NDUFS1/NDUFV3/MT-CO1/NDUFA10/ATP5MC3/PPA2/ATP6V0A1/ATP5F1A/COX15	0.557477354446447
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/826	23/9376	1.48057690283188	ASL/GLUD1/ASS1	0.717206058466255
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/826	23/9376	1.48057690283188	B4GALT1/RXYLT1/B3GALNT2	0.717206058466255
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/826	23/9376	1.48057690283188	MSH3/MSH2/POLD2	0.717206058466255
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/826	85/9376	1.20188007406352	NTPCR/NT5C/ADK/GMPS/NT5C3B/UCKL1/DCK/ASMTL/ITPA	0.58111795301251
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/826	44/9376	1.28989654413383	TDG/PARG/POLD2/UNG/LIG3	0.599065922650879
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/826	183/9376	1.11650061525027	CSNK2A2/FBL/EMG1/WDR36/WDR75/GNL3L/NMD3/GNL3/NOP56/MDN1/RBM28/EFL1/UTP6/XPO1/POP1/DROSHA/HEATR1/NOP58	0.494672466545646
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/826	65/9376	1.22242503259452	MAP2K1/CGA/RAF1/AKT1/ITPR3/PIK3CB/TRPC4	0.559287074202223
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/826	34/9376	1.33542230451503	RORA/RORB/CSNK1D/BTRC	0.608981458483708
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/826	238/9376	1.09695403585163	MAP2K1/FGF10/PRKACA/RRAS2/PAK3/RASA1/RAB5B/BAD/RAF1/AKT1/IKBKB/RASA3/TIAM1/PLAAT3/PAK1/PIK3CB/VEGFA/PLA2G4C/VEGFB/PTPN11/VEGFC/GNB5/FGF7	0.470892093060586
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/826	14/9376	1.6215842269111	B4GALT1/CHST2	0.723389647730597
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/826	24/9376	1.41888619854722	B4GALT7/B3GAT3/HS2ST1	0.638619282850444
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/826	109/9376	1.14552280249683	MLXIP/CREB3L2/AKT1/CREB3/IKBKB/PDPK1/OGA/GFPT1/PIK3CB/PTPN11/SLC2A1	0.47497124913194
NA	NA	hsa04518	Integrin signaling	15/826	154/9376	1.10562560925757	COL1A1/COL6A3/ACTG1/COL1A2/COL6A1/LAMA2/ICAM3/C3/AKT1/PIK3CB/VEGFA/VEGFB/ICAM4/LAMC1/VEGFC	0.410780323875548
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/826	46/9376	1.23381408569323	FTL/BLVRB/UROS/COX15/BLVRA	0.49408465876566
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/826	122/9376	1.11650061525027	MAP2K1/CREB3L2/PRKACA/CSH1/STAT5B/RAF1/AKT1/ITPR3/CREB3/PIK3CB/SOCS2/ADCY9	0.402564979249348
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/826	166/9376	1.09408092418099	MAP2K1/CREB3L2/PPP3CB/PPP3CC/BAD/RAF1/AKT1/ITPR3/CREB3/SLC25A4/PPIF/ADCY9/TRPC6/NFATC3/SLC8A1/SRF	0.380117976200609
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/826	47/9376	1.20756272216784	ALDH9A1/ME3/MDH1/ADH5/ACACA	0.443377188059937
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	28/826	300/9376	1.05943502824859	MAP2K1/FGF10/PRKACA/RRAS2/RASA1/PPP3CB/PPP3CC/MKNK1/MAP3K20/RAF1/AKT1/CASP3/IKBKB/TRADD/CACNB2/PPM1B/TP53/PAK1/VEGFA/PLA2G4C/MAP3K4/HSPB1/VEGFB/MAPK8IP3/VEGFC/NFATC3/FGF7/SRF	0.325198446080014
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/826	69/9376	1.15155981331368	CREB3L2/PRKACA/PPP3CB/PPP3CC/CREB3/SIRT1/MAOB	0.392732059067029
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/826	157/9376	1.08449900525902	MAP2K1/VPS41/RAB5B/CASP3/SIRT1/ARNT/PBX1/RXRA/GAS6/RAB7A/VPS11/PTPN11/NFATC3/SLC2A1/MERTK	0.331857868624651
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/826	59/9376	1.15434809373333	NT5C/NT5C3B/UCKL1/DCK/ASMTL/CDADC1	0.369642443701046
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/826	70/9376	1.13510895883777	CAMKK2/AKT1/IKBKB/TRADD/RXRA/PTPN11/SLC2A1	0.352650291920601
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/826	27/9376	1.26123217648641	ACOX1/ACOX3/ELOVL5	0.422492083290246
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/826	71/9376	1.1191215087133	CASP3/IKBKB/PAK1/ATP6V0A1/CCL5/PTPN11/LYN	0.313150980164815
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/826	138/9376	1.06930554093413	ACTG1/MAP2K1/ARHGEF1/IRF3/ARPC4/BAIAP2/AKT1/IKBKB/PIP5K1A/PIK3CB/PIP5K1C/NFATC3/LIMK1	0.254924235941591
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/826	17/9376	1.33542230451503	CA5B/GLUD1	0.430223649494999
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/826	39/9376	1.16421431675669	MAT2B/MAT2A/GART/AHCYL2	0.319398039669415
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/826	51/9376	1.11285192042919	PLD3/PLAAT3/PLA2G7/PLA2G4C/SELENOI	0.251166796414145
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/826	86/9376	1.05591531054676	MAP2K1/PAK3/STAT5B/BAD/RAF1/AKT1/PAK1/PIK3CB	0.161906660237743
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	14/826	154/9376	1.03191723530707	PDXK/MAT2B/MAT2A/DHRS3/GGCX/VKORC1L1/UGP2/RDH11/COQ4/NADK/FLAD1/UROS/AFMID/COX15	0.1241268320136
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/826	41/9376	1.10742337447588	RBBP8/RAD50/POLD2/RAD51B	0.214252630349612
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/826	75/9376	1.05943502824859	CGA/CREB3L2/PRKACA/ITPR3/CREB3/TTF1/ADCY9	0.160620468178889
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/826	109/9376	1.04138436590621	CTSK/MAP2K1/IRF3/TRAF3/AKT1/IKBKB/RIPK1/PIK3CB/CCL5/CCL4L2	0.135074253874646
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/826	155/9376	1.0252597047567	MAP2K1/CREB3L2/PRKACA/CDK6/E2F3/CDK4/ITPR3/CREB3/ARNT/WNT4/PBX1/DVL3/ADCY9/RBBP5	0.0985593232201941
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/826	19/9376	1.19485153561871	IDS/IDUA	0.264243871107586
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/826	19/9376	1.19485153561871	BCKDHB/DLST	0.264243871107586
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/826	76/9376	1.04549509366637	ME3/HMGCS1/ACOX1/PDPK1/SORBS1/RXRA/ACOX3	0.123772023144773
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/826	133/9376	1.02415845910175	MAP2K1/SOD2/SGK3/RAF1/AKT1/IKBKB/PDPK1/SIRT1/GABARAPL1/BCL2L11/CCNG2/PIK3CB	0.0872129905332387
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/826	99/9376	1.03191723530707	MAP2K1/RAF1/AKT1/PDPK1/PIP5K1A/PIK3CB/PLA2G4C/PIP5K1C/TSC2	0.0992274175899421
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/826	65/9376	1.04779288508102	CREB3L2/PRKACA/ITPR3/CREB3/PBX1/ADCY9	0.120175065516907
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/826	362/9376	1.00341123433173	COL1A1/COL6A3/COL1A2/MAP2K1/COL6A1/FGF10/LAMA2/CREB3L2/CDK6/CDK4/CSH1/BAD/EIF4E2/SGK3/RAF1/AKT1/CREB3/IKBKB/PDPK1/MLST8/TP53/BCL2L11/PIK3CB/VEGFA/TSC2/RXRA/VEGFB/LAMC1/VEGFC/GNB5/FGF7/PRLR	0.0205730966711822
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/826	181/9376	1.00341123433173	NFYC/IFNGR2/PPP3CB/PPP3CC/RAB5B/C3/BAD/RAF1/AKT1/CASP3/CASP10/TRADD/PIK3C3/ATP6V0A1/FCER1G/RAB7A	0.0144034848134978
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/826	193/9376	0.999836906748297	MAP2K1/CXCL12/PRKACA/STAT5B/BAD/RAF1/AKT1/IKBKB/TIAM1/PAK1/PIK3CB/CCL5/CXCL14/ADCY9/GNB5/CCL4L2/LYN	-0.000711565623170244
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/826	67/9376	1.01651548552636	MAP2K1/PRKACA/PPP3CB/PPP3CC/RAF1/ITPR3	0.0421667215835784
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/826	148/9376	0.997055166546692	MAP2K1/FGF10/CDK6/E2F3/CDK4/RAF1/AKT1/WNT4/TP53/PIK3CB/DVL3/NCOA3/FGF7	-0.0112235541780684
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/826	56/9376	1.01349014181944	SAR1B/C3/CASP3/RAB1A/SEC22B	0.0314698865433417
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/826	149/9376	0.990363521133627	MAP2K1/RRAS2/RAF1/AKT1/DNM2/PIP5K1A/PIK3CB/PLA2G4C/PIP5K1C/FCER1G/TSC2/ADCY9/PTPN11	-0.0368530852419495
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/826	104/9376	0.982305829763457	SAMD8/LPIN1/PLD3/PLAAT3/PEMT/PLA2G4C/PNPLA6/SELENOI/GPD2	-0.0563965794398593
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/826	139/9376	0.979950180291602	MAP2K1/CREB3L2/PRKACA/RAF1/AKT1/ITPR3/FKBP4/CREB3/PIK3CB/NCOA3/ADCY9/FKBP5	-0.074019305261734
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/826	128/9376	0.975484261501211	PAPSS1/NTPCR/NT5C/ADK/GMPS/DCK/PDE4B/GART/ITPA/ADCY9/PRPS1	-0.0867997869119493
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/826	93/9376	0.976437814053998	IFNGR2/STAT6/MAML1/PPP3CB/PPP3CC/STAT5B/IKBKB/NFATC3	-0.0709750132936038
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/826	93/9376	0.976437814053998	MAP2K1/CGA/PRKACA/RAF1/ITPR3/PLA2G4C/MAP3K4/ADCY9	-0.0709750132936038
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/826	233/9376	0.974342453938002	COL3A1/FBLN1/VCAN/COL1A1/COL6A3/ACTG1/COL1A2/COL6A1/ZYX/LAMA2/TMEM43/PLEC/DAAM1/PDLIM4/SGCB/TPM2/DCN/SDC3/ENO1/SDC2	-0.123265437757217
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/826	187/9376	0.971216221465474	IRF3/MFN1/TXN2/TRIP6/TRAF3/ITPR3/IKBKB/MCU/GABARAPL1/ATG5/TP53BP1/RIPK1/TRPM7/TAB3/CCL5/GBP1	-0.123573994823899
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/826	94/9376	0.966050177734274	MAPK6/TRAF3/CASP3/IKBKB/TRADD/IL17RA/TAB3/TRAF3IP2	-0.10281897125352
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	12/826	142/9376	0.95924700746854	CTSK/MAP2K1/IFNGR2/PPP3CB/PPP3CC/TMEM64/AKT1/ITPR3/IKBKB/LILRB1/PIK3CB/TYROBP	-0.152090240445762
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/826	142/9376	0.95924700746854	ACTG1/TXN2/AKT1/IKBKB/GSTM3/ASS1/TP53/PIK3CB/VEGFA/PIAS4/ACVR2A/SDC2	-0.152090240445762
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/826	35/9376	0.972950536146662	ENOSF1/PFKM/PFKFB3	-0.0498297378075089
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/826	23/9376	0.987051268554585	GLUD1/MDH1	-0.0193245005895617
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/826	60/9376	0.94592413236481	MAP2K1/RAF1/ITPR3/PLA2G4C/LYN	-0.1306041527183
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/826	144/9376	0.94592413236481	TBX3/MAP2K1/RAF1/AKT1/ID2/TCF3/WNT4/PCGF6/PIK3CB/DVL3/ID4/ACVR2A	-0.203249482718126
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/826	36/9376	0.94592413236481	RNASEH1/POLD2/RNASEH2B	-0.101035480938808
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/826	168/9376	0.94592413236481	FTL/IFNGR2/STAT6/CAPN1/CAPN2/CHMP2B/STAT5B/GLUD1/CHMP4A/TRADD/SLC25A4/RIPK1/TRPM7/PLA2G4C	-0.219820446854588
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/826	109/9376	0.937245929315592	RORA/IFNGR2/STAT6/PPP3CB/PPP3CC/STAT5B/IKBKB/RXRA/NFATC3	-0.204822741382649
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/826	133/9376	0.93881192084327	MAP2K1/IFNGR2/PPP3CB/PPP3CC/RAF1/CASP3/PAK1/PIK3CB/FCER1G/TYROBP/PTPN11	-0.220891379941382
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/826	61/9376	0.930417179375223	FTL/SLC40A1/TRPM7/SLC8A1/CYBRD1	-0.169460358879703
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/826	216/9376	0.94592413236481	ARHGEF1/IRF3/SOD2/PPP3CB/PPP3CC/XBP1/TRAF3/BAD/AKT1/CASP3/IKBKB/PDPK1/TP53/PIK3CB/CCL5/RXRA/NFATC3/LYN	-0.249905169266311
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/826	49/9376	0.926619558234916	CREB3L2/PRKACA/CREB3/MAOB	-0.160066326514878
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/826	217/9376	0.941565034980641	MAP2K1/FGF10/AR/CREB3L2/PRKACA/KPNA2/STAT5B/BAD/RAF1/AKT1/CREB3/GSTM3/ARNT/PIK3CB/VEGFA/RXRA/ADCY9/FGF7	-0.270689388070416
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/826	158/9376	0.933950409170319	CDK6/WAPL/E2F3/CDK4/SMC3/CDK7/TFDP2/SMC1A/ATR/TP53/FZR1/CDC14B/PDS5B	-0.260239327284239
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/826	37/9376	0.92035861527387	MAP2K1/TP53/RXRA	-0.150862771311671
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/826	63/9376	0.900880126061724	PTGDS/LTA4H/CBR1/PLAAT3/PLA2G4C	-0.245345907871981
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/826	112/9376	0.912141127637496	IFNGR2/LAMA2/BAD/AKT1/CASP3/IKBKB/PDPK1/PPIF/LAMC1	-0.290728741003819
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/826	101/9376	0.899096205020018	MAP2K1/CREB3L2/PRKACA/RAF1/CREB3/WNT4/DVL3/ADCY9	-0.316886569159691
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/826	89/9376	0.892782327175776	COL1A1/COL6A3/COL1A2/COL6A1/LAMA2/CD44/LAMC1	-0.315875732189012
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/826	89/9376	0.892782327175776	MAP2K1/PRKACA/TUBA1C/CSNK1D/RAF1/ITPR3/ADCY9	-0.315875732189012
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/826	138/9376	0.904796996175036	MAP2K1/AR/PRKACA/PPP3CB/PPP3CC/SMC3/CPEB2/ITPR3/SMC1A/ADCY9/BTRC	-0.35018200106812
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/826	52/9376	0.873160737567517	CGA/PRKACA/PLA2G4C/ADCY9	-0.285066938647089
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/826	52/9376	0.873160737567517	APOE/APOC1/OSBPL5/MYLIP	-0.285066938647089
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/826	115/9376	0.888346141699126	MAP2K1/CREB3L2/PRKACA/AKT1/ITPR3/CREB3/PIK3CB/ADCY9/GNB5	-0.374443518667526
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/826	103/9376	0.881638026281765	COL3A1/COL1A1/COL6A3/COL1A2/COL6A1/SLC1A5/SLC36A4/SLC8A1	-0.375416438645707
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/826	140/9376	0.891871324801107	MAP2K1/PRKACA/RRAS2/RAF1/AKT1/ITPR3/PIK3C3/ADCY9/HDAC4/GNB5/SLC8A1	-0.400641139326964
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/826	27/9376	0.840821450990943	HMGCS1/ECHS1	-0.257440249859316
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/826	238/9376	0.906179420920911	CFD/RPL13A/RPL3/RPS2/RPLP0/RPL18A/IRF3/RPL6/RPL26L1/RPL12/C3/C1R/TRAF3/IKBKB/C1S/RPL10A/PIK3CB/RPL37A/RPL5	-0.455673334963768
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/826	54/9376	0.840821450990943	REV3L/FANCL/ATR/FANCM	-0.364602361052209
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/826	67/9376	0.847096237938636	ALDH9A1/PFKM/ADPGK/ADH5/ENO1	-0.390388181663284
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/826	105/9376	0.864844921019255	ACTG1/LAMA2/PRKACA/SGCB/CACNB2/TPM2/ADCY9/SLC8A1	-0.432868849802046
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/826	28/9376	0.810792113455552	B4GALT1/ST3GAL4	-0.311638785353597
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/826	28/9376	0.810792113455552	CBR1/QDPR	-0.311638785353597
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/826	155/9376	0.878794032648598	ACTG1/M6PR/SEC61A1/TUBA1C/RAB5B/C3/C1R/PIKFYVE/PIK3C3/ATP6V0A1/RAB7A/SEC22B	-0.472926276354661
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/826	29/9376	0.782833764715705	PAK1/NF2	-0.364038892734148
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/826	15/9376	0.756739305891848	ST6GALNAC6	-0.293054944294149
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/826	15/9376	0.756739305891848	NTPCR	-0.293054944294149
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/826	134/9376	0.847096237938636	MAP2K1/ARHGEF1/PRKACA/PPP1R12B/PPP1R12C/RAF1/ITPR3/PLA2G4C/ADCY9/ARHGEF11	-0.55408984729192
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/826	30/9376	0.756739305891848	PLAAT3/PLA2G4C	-0.414774726012689
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/826	30/9376	0.756739305891848	IKBKB/GART	-0.414774726012689
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/826	110/9376	0.825533788245653	MAP2K1/PRKACA/RAF1/CPEB2/AKT1/PIK3CB/ADCY9/FZR1	-0.57207652940782
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/826	98/9376	0.810792113455552	CREB3L2/PRKACA/ATF1/ITPR3/CREB3/CAMK1/ADCY9	-0.585218023346516
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/826	16/9376	0.709443099273608	MAOB	-0.361531269223503
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/826	149/9376	0.837999902497684	NDUFA5/PRKACA/NDUFA9/NDUFB1/NDUFS1/NDUFV3/ITPR3/CNR1/NDUFA10/ADCY9/GNB5	-0.619542001310277
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/826	150/9376	0.832413236481033	MAP2K1/FGF10/E2F3/RAF1/AKT1/WNT4/TP53/PIK3CB/DVL3/RXRA/FGF7	-0.643089209756684
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/826	86/9376	0.791936482910074	CREB3L2/PRKACA/ITPR3/CREB3/ADCY9/SLC2A1	-0.602462346000464
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/826	73/9376	0.777471889614913	GSTK1/GSTM3/ADH5/AOX1/MAOB	-0.59323587193374
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/826	125/9376	0.817278450363196	MAP2K1/RAF1/SPTLC2/AKT1/PDPK1/TRADD/TP53/PIK3CB/FCER1G	-0.639209234203327
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/826	32/9376	0.709443099273608	CASP3/BCL2L11	-0.511719978730137
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/826	47/9376	0.724537633300706	IKBKB/PIK3CB/SOCS2	-0.588418422575449
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/826	88/9376	0.773937926480299	CFD/PLAUR/C3/C1R/F3/C1S	-0.662217333181245
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/826	115/9376	0.789641014843668	MAP2K1/PRKACA/RAF1/ITPR3/CASP3/PLA2G4C/GNB5/MAOB	-0.705462039413022
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/826	18/9376	0.630616088243207	ACACA	-0.487545680141416
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/826	18/9376	0.630616088243207	MAN2B2	-0.487545680141416
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/826	76/9376	0.746782209761692	ACTG1/EZR/PRKACA/ITPR3/ADCY9	-0.688893585402419
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/826	116/9376	0.782833764715705	ACTG1/CXCL12/EZR/CLDN4/ARHGAP35/ARHGAP5/PIK3CB/PTPN11	-0.731490025312475
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/826	116/9376	0.782833764715705	PRKACA/PPP3CB/PPP3CC/ITPR3/PLA2G4C/ADCY9/GNB5/GRIK1	-0.731490025312475
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/826	78/9376	0.727633947972931	IRF3/C3/C1R/CASP3/C1S	-0.750754788019605
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/826	79/9376	0.718423391669476	GSTK1/AKR7A2/GSTM3/CBR1/ADH5	-0.781144371981077
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/826	79/9376	0.718423391669476	STXBP1/DNM2/AP2A2/AP2A1/ATP6V0A1	-0.781144371981077
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/826	36/9376	0.630616088243207	UGP2/GAA	-0.690157787706388
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/826	36/9376	0.630616088243207	GALNT13/GALNT11	-0.690157787706388
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/826	93/9376	0.732328360540498	ACTG1/CSNK2A2/BAIAP2/CCM2/KRIT1/SORBS1	-0.806291836101153
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/826	133/9376	0.768118844326312	CREB3L2/PRKACA/PPP3CB/PPP3CC/AKT1/ITPR3/CREB3/GNB5/MAOB	-0.837100120890625
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/826	20/9376	0.567554479418886	CYP51A1	-0.601719240493389
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/826	212/9376	0.803143131253141	ACTG1/MAP2K1/FGF10/RAF1/AKT1/CNR1/KRIT1/TIAM1/PIK3CB/VEGFA/VEGFB/ADCY9/VEGFC/FGF7/ENAH	-0.901090824692862
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/826	226/9376	0.803616962009042	MAP2K1/CGA/CREB3L2/PRKACA/RRAS2/BAD/RAF1/AKT1/ACOX1/CREB3/TIAM1/PAK1/PIK3CB/PDE4B/ACOX3/ADCY9	-0.928838591433627
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/826	95/9376	0.716910921371225	CTSK/CXCL12/IL15/VEGFA/ATP6V0A1/CCL5	-0.861946153094413
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/826	82/9376	0.692139609047422	GMPS/UCKL1/GSTM3/ITPA/CDADC1	-0.870265993094457
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/826	38/9376	0.597425767809354	PDPK1/PIK3CB	-0.772864645932664
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/826	68/9376	0.667711152257513	DHRS3/RDH11/ADH5/AOX1	-0.854741202153327
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/826	110/9376	0.722342064714946	ZFYVE16/NBL1/ID2/DCN/NCOR1/ID4/ACVR2A	-0.910443267972527
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/826	254/9376	0.804407923585823	FGF10/PRKACA/PPP3CB/PPP3CC/PLCD3/ITPR3/MCU/SLC25A4/CAMK1/VEGFA/P2RX4/VEGFB/PPIF/ADCY9/VEGFC/NFATC3/FGF7/SLC8A1	-0.98223563499297
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/826	69/9376	0.65803417903639	PRKACA/PPP3CB/PPP3CC/ITPR3	-0.886125009402221
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/826	70/9376	0.648633690764441	ACTG1/LAMA2/CASP3/SGCB	-0.917107441200581
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/826	99/9376	0.687944823538044	ACTG1/LAMA2/SGCB/CACNB2/TPM2/SLC8A1	-0.970147602321891
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/826	23/9376	0.493525634277292	PREP	-0.755855059645378
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/826	194/9376	0.760640023963456	ACTG1/DCTN3/KIF3A/TUBA1C/DYNLT3/DCTN1/TPM2/KIF2A/DCTN2/HOOK3/MYO19/DCTN5/ACTR1B	-1.04707154619745
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/826	86/9376	0.659947069091728	ACTG1/LAMA2/SGCB/CACNB2/SLC8A1	-0.984646849119568
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/826	41/9376	0.553711687237938	SDSL/MAOB	-0.890108371386487
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/826	87/9376	0.652361470596421	MT-CO3/MT-CO1/CACNB2/TPM2/SLC8A1	-1.01250144909069
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/826	103/9376	0.661228519711324	IFNGR2/C3/AKT1/IKBKB/PIK3CB/CCL5	-1.07450373333134
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/826	59/9376	0.577174046866664	GSTK1/GSTM3/IDH1	-1.01260997007495
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/826	201/9376	0.734150072880151	ZEB1/ATF1/DDX5/CCNT1/ID2/TCF3/TP53/PBX1/NCOR1/SUPT3H/HOXA9/RXRA/TAF15	-1.18419750666367
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/826	45/9376	0.504492870594565	ABCB7/ABCB8	-1.03558243179288
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/826	78/9376	0.582107158378345	ACTG1/ARPC4/DNM2/PIK3CB	-1.15188750356963
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/826	28/9376	0.405396056727776	ATP6V0A1	-0.97935479346039
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/826	63/9376	0.540528075637034	WNT4/TP53/DVL3	-1.13730528445504
NA	NA	hsa04517	IgSF CAM signaling	20/826	299/9376	0.75927020658045	ACTG1/MAP2K1/EZR/PAK3/ARPC4/RASA1/ICAM3/TUBA1C/BAIAP2/AKT1/PDPK1/SORBS1/NLGN2/PAK1/PIK3CB/TRPC6/PTPN11/KIRREL1/NLGN1/LYN	-1.31488228435458
NA	NA	hsa03272	Virion - Hepatitis viruses	2/826	48/9376	0.472962066182405	CLDN4/CHMP4A	-1.13778663853587
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/826	48/9376	0.472962066182405	AKT1/PIK3CB	-1.13778663853587
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/826	65/9376	0.52389644254051	ALDH9A1/ABHD16A/LPIN1	-1.19716096053904
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/826	97/9376	0.58510771074112	PRKACA/ITPR3/ADCY9/GNB5/NOS1AP	-1.27662471464889
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/826	66/9376	0.515958617653533	RORA/IFNGR2/STAT6	-1.22651319374119
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/826	170/9376	0.667711152257513	ACTG1/EZR/PRKACA/ARPC4/CDK4/TUBA1C/CLDN4/TIAM1/SYMPK/NF2	-1.35893081151901
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/826	50/9376	0.454043583535109	CXCL12/IL15	-1.20306162946905
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/826	31/9376	0.366164180270249	ALDH9A1	-1.09865307913959
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/826	99/9376	0.57328735294837	PRKACA/ITPR3/PIK3CB/PLA2G4C/ADCY9	-1.3266059422925
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/826	100/9376	0.567554479418886	CXCL12/TNFRSF14/CCL5/CXCL14/CCL4L2	-1.35127467476755
Human Diseases	Immune disease	hsa05310	Asthma	1/826	32/9376	0.354721549636804	FCER1G	-1.13644478609651
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/826	160/9376	0.638498789346247	VCAN/CD276/ICAM3/CLDN4/NLGN2/SDC3/GLG1/NLGN1/SDC2	-1.43347828637557
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/826	70/9376	0.486475268073331	GSTK1/GSTM3/CBR1	-1.34036001890764
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/826	89/9376	0.510161329814729	PRKACA/GABARAPL1/ADCY9/GNB5	-1.4431216843601
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/826	55/9376	0.412766894122826	SAMD8/SPTLC2	-1.35754184954868
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/826	90/9376	0.504492870594565	PRKACA/RXRA/ADCY9/SLC2A1	-1.46807900238026
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/826	36/9376	0.315308044121603	UGP2	-1.27928009447397
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/826	91/9376	0.498948992895724	PRKACA/PDE4B/ADCY9/GNB5	-1.49280914189971
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/826	154/9376	0.589666991604038	CREB3L2/PRKACA/AKT1/CREB3/CACNB2/TPM2/ADCY9/SLC8A1	-1.59579411915809
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/826	37/9376	0.30678620509129	APOL1	-1.31313832087472
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/826	323/9376	0.702853844481593	TIMP3/ZEB1/UBE2I/MAP2K1/EZR/CDK6/E2F3/DNMT1/PIM1/RAF1/CASP3/IKBKB/SIRT1/TP53/BCL2L11/CD44/PIK3CB/VEGFA/MDM4/HDAC4	-1.68914806956891
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/826	38/9376	0.298712883904677	UNG	-1.34633559562122
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/826	99/9376	0.458629882358696	CFD/C3/C1R/C1S	-1.68306428226311
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/826	157/9376	0.506099535787542	ACTG1/CSNK1D/ID2/WNT4/DVL3/NF2/BTRC	-1.93972408153029
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/826	191/9376	0.534868095787432	MAP2K1/CAMKK2/CREB3L2/PRKACA/RAF1/CREB3/HDAC4/GNB5/MAOB	-2.01857940219695
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/826	50/9376	0.227021791767554	SDC2	-1.70332355238469
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/826	93/9376	0.366164180270249	PRKACA/ITPR3/ADCY9	-1.90926707031248
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/826	195/9376	0.52389644254051	ACTG1/MAP2K1/C3/RAF1/AKT1/SLC25A4/PIK3CB/PPIF/HDAC4	-2.08817236040351
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/826	54/9376	0.210205362747736	CGA	-1.80904394016158
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/826	78/9376	0.291053579189172	IFNGR2/C3	-1.95415293466968
NA	NA	hsa04081	Hormone signaling	10/826	219/9376	0.518314593076608	CGA/PRKACA/SLC40A1/CSH1/STAT5B/THRA/PIK3CB/ADCY9/GNB5/PRLR	-2.24182415375573
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/826	82/9376	0.276855843618969	NFYC/PSME2	-2.04419855849638
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/826	143/9376	0.396891244348871	SNRPD1/C3/C1R/SSB/C1S	-2.25883671879659
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/826	86/9376	0.263978827636691	PRKACA/ITPR3	-2.13120035847688
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/826	66/9376	0.171986205884511	STS	-2.09810541024244
NA	NA	hsa04382	Cornified envelope formation	8/826	217/9376	0.418473348880285	S100A4/PLEC/CAPN1/CLDN4/S100A6/SPTLC2/ABHD5/BLMH	-2.69381684897191
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/826	102/9376	0.222570384085838	ITPR3/ADCY9	-2.45369300885926
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/826	298/9376	0.457090855907828	CXCL12/IFNGR2/CSH1/IL15/IL17RA/TNFRSF14/CCL5/CXCL14/ACVR2A/CCL4L2/TNFRSF12A/PRLR	-2.96028008685503
NA	NA	hsa04082	Neuroactive ligand signaling	6/826	199/9376	0.342243907187268	PRKACA/OGFRL1/P2RX4/ADCY9/GNB5/GRIK1	-2.91496709383883
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/826	100/9376	0.113510895883777	CD44	-2.77003742399717
NA	NA	hsa04519	Cadherin signaling	13/826	404/9376	0.365257833289382	ACTG1/MAP2K1/RRAS2/ARPC4/DAAM1/RAF1/IKBKB/ARHGAP35/WNT4/LHFPL2/DVL3/NF2/ENAH	-4.05355438904606
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/826	370/9376	0.30678620509129	CGA/NMB/CSH1/C3/THRA/CNR1/OGFRL1/P2RX4/GRIK1/PRLR	-4.22858136707617
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/826	449/9376	0.0505616462733974	PRKACA/SLC8A1	-6.40810735993616