category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	52/1503	138/9376	2.3506224266443	NDUFA4/MT-CO2/UQCR11/NDUFS8/ATP6V0C/NDUFC2/UQCR10/ATP6V0B/COX7B/COX8A/COX17/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/ATP5MG/NDUFB3/ATP6V1H/NDUFS2/ATP6V1G1/ATP6V0E1/SDHC/NDUFS4/ATP6AP1/NDUFC1/ATP6V1E1/COX7A2/ATP6V1C1/ATP6V1F/ATP5MF/NDUFS6/COX6B1/NDUFAB1/COX7A2L/NDUFB4/COX7A1/PPA1/NDUFA1/NDUFB11/MT-ATP6/ATP5PD/NDUFA8/ATP5PF/COX6A1/COX6C/COX5B/COX10/NDUFB2/NDUFA4L2/ATP5F1E	6.98360269307417
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	67/1503	235/9376	1.7785478688014	CNR1/PLIN1/NDUFA4/SMARCB1/RHEB/MT-CO2/UQCR11/NDUFS8/NDUFC2/UQCR10/MAPK14/COX7B/COX8A/COX17/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/ATP5MG/NDUFAF8/RPS6KA2/COX20/NDUFB3/NDUFS2/SDHC/MAP3K5/NDUFS4/NDUFC1/PNPLA2/PRKAG1/COX7A2/NDUFAF3/COX16/ADCY9/ATP5MF/NDUFS6/COA3/PRKACB/COX14/COX6B1/NDUFAB1/COX7A2L/NDUFB4/RPS6KB2/COX7A1/NPR1/NDUFA1/NDUFB11/SMARCD1/MT-ATP6/ATP5PD/NDUFA8/ATP5PF/COX6A1/COX6C/COX5B/COX10/PRKG2/NDUFB2/NDUFA4L2/PRKAA2/ATP5F1E/ADCY2/PPARGC1A/RPS6KA6	5.28101498290925
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	59/1503	205/9376	1.79538159453451	REN/CTSD/TGFBR1/MMP9/NDUFA4/PPP1CB/MT-CO2/UQCR11/RAC2/NDUFS8/TBC1D4/NDUFC2/UQCR10/MAPK14/COX7B/COX8A/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/SDHC/NDUFS4/NDUFC1/SMAD2/COX7A2/NDUFS6/GFPT1/CYBA/PPIF/COX6B1/NDUFAB1/COX7A2L/NDUFB4/PIK3CB/COX7A1/NDUFA1/NDUFB11/MT-ATP6/ATP5PD/NDUFA8/ATP5PF/COX6A1/CAMK2G/COX6C/RYR2/PDK4/COX5B/NDUFB2/NDUFA4L2/ATP5F1E/CD36/NOS3/NCF1/PRKCD	5.03082399415567
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	66/1503	250/9376	1.64688223552894	CTSD/GPR155/NPC2/CD68/DEPTOR/AGA/SLC29A1/BORCS7/ASAH1/VPS41/ATP6V0C/CTSB/CTSZ/ATP6V0B/VAMP8/ACP5/ACP2/LAPTM4A/ATP6V1H/ATP6V1G1/ATP6V0E1/GM2A/ATP6AP1/HEXB/CTSO/GNPTG/MITF/ATP6V1E1/CLTB/CLN5/GALNS/HEXA/ATP6V1C1/SGSH/ATP6V1F/BORCS8/SNAPIN/IDS/FIG4/GAA/BORCS5/CTBS/CD164/LAMTOR2/VPS29/ARSB/KXD1/FUCA2/CTSA/GNS/TPP1/CTSL/AP3M1/TMEM175/LAMTOR5/BLOC1S1/CTSK/GALC/AP5B1/VAMP7/CLN6/AP4E1/SORT1/LAMP5/RRAGD/TLR7	4.5294972439432
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	21/1503	52/9376	2.51926915399969	APOA1/NPC2/APOC3/APOC1/SCARB1/STARD3NL/TSPO/NCEH1/ANGPTL4/APOC2/VAPA/SOAT2/SOAT1/LRPAP1/CYP27A1/STARD3/PLTP/LPL/SORT1/APOE/CD36	4.79987870309839
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	66/1503	268/9376	1.53627074209789	MAOB/MAOA/CALM2/NDUFA4/MT-CO2/UQCR11/NDUFS8/NDUFC2/UQCR10/COX7B/COX8A/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/SDHC/MAP3K5/NDUFS4/SNCAIP/NDUFC1/SLC39A6/COX7A2/SLC39A2/NDUFS6/SLC39A10/KLC1/PPIF/UBE2L6/PRKACB/COX6B1/NDUFAB1/PSMD3/MCU/COX7A2L/NDUFB4/SLC39A4/COX7A1/CALM3/NDUFA1/NDUFB11/MT-ATP6/PSMA2/ATP5PD/NDUFA8/TH/ATP5PF/COX6A1/CAMK2G/COX6C/COX5B/NDUFB2/NDUFA4L2/GPR37/ATP5F1E/CALML4/TUBA3D/KIF5C/KIF5A/SNCA/UCHL1	3.89166091048806
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	67/1503	275/9376	1.51984999697575	NDUFA4/HSPA1B/MT-CO2/UQCR11/RAC2/NDUFS8/C1QB/NDUFC2/UQCR10/MAPK14/COX7B/COX8A/C1QA/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/SDHC/NDUFS4/NDUFC1/COX7A2/CAV2/NDUFS6/KLC1/CYBA/PPIF/HSPA1A/PRKACB/COX6B1/NDUFAB1/PSMD3/MCU/COX7A2L/NDUFB4/PIK3CB/COX7A1/IL1B/NDUFA1/NDUFB11/MT-ATP6/PSMA2/ATP5PD/NDUFA8/ATP5PF/COX6A1/CSNK2B/GRIN2D/COX6C/RYR2/COX5B/C7/NDUFB2/C1QC/NDUFA4L2/ATP5F1E/NCAM2/TUBA3D/KIF5C/KIF5A/NCF1/PRKCD	3.82291672892563
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	42/1503	157/9376	1.6688152357705	NDUFA4/MT-CO2/UQCR11/NDUFS8/NDUFC2/UQCR10/MAPK14/COX7B/COX8A/NDUFA5/NDUFA3/NDUFA7/UQCRQ/NDUFA13/ADIPOR1/NDUFB3/NDUFS2/SDHC/MAP3K5/NDUFS4/NDUFC1/PRKAG1/COX7A2/LEPR/NDUFS6/COX6B1/NDUFAB1/COX7A2L/NDUFB4/PIK3CB/COX7A1/IL1B/NDUFA1/NDUFB11/FAS/NDUFA8/COX6A1/COX6C/COX5B/NDUFB2/NDUFA4L2/PRKAA2	3.69240286578632
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/1503	20/9376	3.11909514304724	TM7SF2/SC5D/HSD17B7/FDFT1/SOAT2/SOAT1/MSMO1/EBP/DHCR7/DHCR24	4.14491233954287
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	87/1503	388/9376	1.39876947136655	WNT5A/WNT4/MME/WNT6/CALM2/NDUFA4/DKK1/MT-CO2/UQCR11/NDUFS8/NDUFC2/UQCR10/COX7B/WNT3/COX8A/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/SDHC/MAP3K5/NDUFS4/ADAM10/PSENEN/NDUFC1/NCSTN/APH1B/WNT9A/SLC39A6/COX7A2/SLC39A2/NDUFS6/SLC39A10/KLC1/CSNK1E/PPIF/COX6B1/NDUFAB1/PSMD3/EIF2AK2/MCU/COX7A2L/NDUFB4/SLC39A4/PIK3CB/COX7A1/CDK5/ATG2B/CALM3/IL1B/NDUFA1/NDUFB11/MT-ATP6/FAS/PSMA2/ATP5PD/NDUFA8/APH1A/WNT10B/ATP5PF/COX6A1/PSEN2/CSNK2B/GRIN2D/COX6C/COX5B/LRP5/NDUFB2/FZD3/WNT9B/NDUFA4L2/LPL/APOE/ATP5F1E/CALML4/WNT16/TUBA3D/KIF5C/KIF5A/SNCA/WNT3A	3.5051066458531
NA	NA	hsa04517	IgSF CAM signaling	69/1503	299/9376	1.43958237371411	UNC5B/NFASC/MPDZ/NECTIN2/SORBS1/KCNA4/UNC5C/MYLK/PPFIA1/NCK1/MYLK3/MYL12A/ACTN1/LCP2/RAP1A/PTPRD/TRPC6/MAPK14/MYH10/TUBA3E/ARPC1B/DOK2/MYL9/PVR/LMO7/AFDN/ROBO2/RAP1B/ANK3/CLMP/PIK3CB/LRFN4/KDR/BCAR1/LRFN5/MTSS2/CDH2/NLGN4X/EPB41L1/PAK1/NRP2/FGG/PARD6B/PTPRZ1/CD84/ACTR3B/CD86/ICAM2/PLXNA4/PARD3/PPFIA2/NCAM2/TUBA3D/CNTNAP2/SCN8A/SPTBN4/SSX2IP/PLXNA2/MPP3/SLITRK4/NRCAM/GRIP2/ITGB3/ESAM/IL1RAPL2/CDH1/PPFIA3/LRRTM4/UNC5D	3.37520145086146
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1503	34/9376	2.38519040350671	NR1D1/PER3/SKP1/CRY2/RBX1/PRKAG1/CSNK1E/PER1/DBP/BTRC/FBXL3/PRKAA2/RORB	3.53528152722218
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	69/1503	308/9376	1.39751665500168	NDUFA4/POLR2K/MT-CO2/DNAH14/UQCR11/NDUFS8/NDUFC2/UQCR10/POLR2I/DCTN6/COX7B/SLC1A2/COX8A/POLR2J/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/DCTN4/SDHC/MAP3K5/NDUFS4/POLR2L/GPX8/NDUFC1/CLTB/HIP1/COX7A2/NDUFS6/KLC1/PPIF/COX6B1/DNAI1/NDUFAB1/PSMD3/COX7A2L/NDUFB4/DNAH11/COX7A1/ATG2B/NDUFA1/NDUFB11/MT-ATP6/PSMA2/ATP5PD/NDUFA8/ATP5PF/COX6A1/DNALI1/COX6C/COX5B/TAF4/NDUFB2/GRIA4/NDUFA4L2/ATP5F1E/SLC1A3/DNAH6/TUBA3D/KIF5C/KIF5A/HAP1/PPARGC1A	3.09934509032379
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1503	56/9376	2.00513259195894	ST6GAL2/TUSC3/RPN1/RPN2/ST6GAL1/B4GALT3/ALG8/ALG14/SRD5A3/STT3A/GANAB/DPM2/KRTCAP2/MGAT4B/MAN1A1/ALG9/ALG1/DOLK	3.29613063391348
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	25/1503	88/9376	1.77221314945866	CFH/SERPING1/F3/CLU/SERPINE1/TFPI/PLAUR/VTN/MASP1/C1QB/SERPINB2/C3/CD46/C1QA/F2R/F12/CD59/PROS1/F10/F2RL2/FGG/C7/SERPINA5/C1QC/THBD	3.17989242474329
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	53/1503	227/9376	1.45649376723792	NDUFA4/MT-CO2/MGST2/UQCR11/NDUFS8/NDUFC2/UQCR10/MAPK14/COX7B/PLD1/COX8A/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/SDHC/MAP3K5/NDUFS4/NDUFC1/MGST1/COX7A2/VEGFA/NDUFS6/CYBA/PRKD1/PPIF/COX6B1/NDUFAB1/GSTA1/COX7A2L/NDUFB4/PIK3CB/COX7A1/NDUFA1/NDUFB11/MT-ATP6/ATP5PD/NDUFA8/ATP5PF/COX6A1/COX6C/COX5B/NDUFB2/NDUFA4L2/ATP5F1E/AKR1C2/NCF1/PRKCD	3.04197730633867
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/1503	85/9376	1.76137137489726	UPP1/CDA/NUDT16/PNP/ENTPD3/CMPK1/ENPP1/AK1/AK3/NME1/AK6/RRM1/ENTPD5/ENPP3/HPRT1/NT5C3A/TK2/ADK/AK9/CMPK2/DCK/CTPS2/UPP2/AMPD3	3.08084451176547
NA	NA	hsa04518	Integrin signaling	38/1503	154/9376	1.53929370695838	ITGA1/ITGA3/COL4A6/PDGFRA/LIMS2/PARVA/PDGFD/VTN/LAMA4/FERMT2/TLN2/FREM1/ACTN1/RAC2/LAMC3/C3/ITGA6/COL4A5/VEGFA/PDGFC/FERMT1/PARVB/CCND3/PIK3CB/FLNB/KDR/COL4A4/THBS1/IGF1/ITGB5/FGG/LAMB3/THBS4/ICAM2/RELN/COL4A3/ITGB3/CDH1	2.94827613318248
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1503	59/9376	1.90317669745255	UPP1/NUDT2/CDA/ENTPD3/CMPK1/ENPP1/NME1/RRM1/ENTPD5/ENPP3/NT5C3A/TK2/AK9/CMPK2/DCK/CTPS2/UMPS/UPP2	3.04057475126952
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1503	116/9376	1.61332507398995	THY1/MMP9/CLDN4/CLDN20/CLDN10/MYL12A/ACTN1/RAC2/ITK/RAP1A/RHOH/MAPK14/ROCK2/CTNND1/CTNNA3/MYL9/AFDN/CYBA/CLDN5/RAP1B/CLDN3/PIK3CB/OCLN/BCAR1/CLDN23/RAPGEF3/NCF1/CLDN18/ESAM/CLDN7	2.90408433342941
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/1503	31/9376	2.21355139183998	SEC11C/SEC61G/SRP19/TMEM208/GET1/IMMP1L/SEC62/SPCS1/SRP14/SPCS3/OXA1L	2.95695264554256
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	52/1503	233/9376	1.39221414110263	SGCE/ITGA1/NID2/FBN2/PKP2/ITGA3/COL4A6/DAAM1/FMNL2/COL24A1/TLN2/DCN/FHL2/MYH10/CAPZA1/ITGA6/CSRP1/SDC1/NEB/MYL9/COL4A5/SUN2/CAPZA2/SGCZ/DMD/TPM1/NEBL/ANK3/SDC2/SGCB/PDLIM7/ATP1B3/DAAM2/DSG2/DES/COL27A1/COL4A4/PDLIM5/THBS1/ITGB5/TMOD2/PDLIM1/ACTG2/ELN/THBS4/SNTB1/COL4A3/SPTBN4/TMOD1/MYOM2/ITGB3/AMPD3	2.64881636732739
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	77/1503	368/9376	1.30527351094912	NDUFA4/ANG/MT-CO2/DNAH14/UQCR11/NDUFS8/DERL1/NDUFC2/UQCR10/MAPK14/DCTN6/COX7B/SLC1A2/COX8A/RANBP2/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NRG2/NDUFB3/NDUFS2/DCTN4/SDHC/MAP3K5/NDUFS4/GPX8/NDUFC1/COX7A2/RAB1A/FIG4/NDUFS6/KLC1/NUP160/COX6B1/DNAI1/NDUFAB1/PSMD3/MCU/COX7A2L/CHCHD10/NDUFB4/DNAH11/ANXA11/COX7A1/ALYREF/ATG2B/NDUFA1/NDUFB11/MT-ATP6/PSMA2/ATP5PD/NDUFA8/NXT1/ATP5PF/COX6A1/DNALI1/GRIN2D/COX6C/COX5B/ALS2/NDUFB2/ATXN2L/NUP133/NDUFA4L2/NUP35/ATP5F1E/DNAH6/TUBA3D/KIF5C/KIF5A/NXT2/HAP1/PFN4	2.61032056488399
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/1503	95/9376	1.64162902265644	CCL3/CCL2/HLA-DMA/ATP6V0C/ATP6V0B/ACP5/HLA-DPA1/ATP6V1H/ATP6V1G1/ATP6V0E1/ATP6AP1/ATP6V1E1/ATP6V1C1/ATP6V1F/VEGFA/CTSL/IL18/IL1B/TEK/TNFSF13B/ANGPT1/CTSK/CD86/TLR2/IL23A	2.7462711787503
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/1503	155/9376	1.48911639087417	HLA-DMA/CORO1A/SCARB1/SEC61G/ATP6V0C/C3/ATP6V0B/TUBA3E/STX12/HLA-DPA1/ATP6V1H/ATP6V1G1/ATP6V0E1/MRC2/STX7/ATP6AP1/ATP6V1E1/PLA2R1/ATP6V1C1/ATP6V1F/CYBA/HLA-E/CTSL/DYNC1LI1/COLEC11/DYNC2H1/THBS1/ITGB5/OLR1/THBS4/TUBA3D/FCGR3A/CD36/TLR2/HLA-A/ITGB3/NCF1	2.68277380786736
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1503	100/9376	1.62192947438456	CCL3/CCL8/CCL4/CCL23/CCL2/XCL2/XCL1/CXCL14/CCL21/LTBR/CCL14/IL10RB/ACKR3/CXCL13/IL18/ACKR4/IL2RA/TNFSF10/IL18R1/CCL28/CXCR3/CCL13/TNFSF14/IL34/CCR1/IL10	2.73184322293036
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	40/1503	174/9376	1.43406673243551	HSPA1B/SIL1/SEC61G/BCAP31/DERL1/ERLEC1/AMFR/SKP1/TUSC3/RPN1/RPN2/RAD23A/MAP3K5/SSR1/RBX1/SSR4/SEC24B/WFS1/UGGT2/UBE4B/SEL1L/UBXN2A/SEC62/UBE2D1/HSPA1A/LMAN2/STT3A/GANAB/ERP29/KRTCAP2/PPP1R15A/PDIA6/RNF5/MAN1A1/SELENOS/CRYAB/HSPH1/SVIP/FBXO6/UBE2D4	2.52513740135106
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1503	93/9376	1.6098555577018	TGFBR1/NECTIN2/SORBS1/MYL12A/ACTN1/RAC2/RAP1A/ROCK2/CTNND1/CTNNA3/MYL9/LMO7/AFDN/RAP1B/PDCD10/HEG1/WASF1/CSNK2B/LEF1/PARD3/RASIP1/SSX2IP/CDH1/WASF3	2.58237487590053
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	96/1503	480/9376	1.2476380572189	WNT5A/WNT4/WNT6/CALM2/NDUFA4/DKK1/MT-CO2/DNAH14/UQCR11/NDUFS8/DERL1/NDUFC2/UQCR10/MAPK14/DCTN6/COX7B/WNT3/COX8A/TUBA3E/NDUFA5/NDUFA3/MT-ND4/NDUFA7/UQCRQ/NDUFA13/NDUFB3/NDUFS2/SLC25A4/DCTN4/SDHC/MAP3K5/NDUFS4/SNCAIP/GPX8/NDUFC1/WNT9A/HIP1/COX7A2/RAB1A/FIG4/NDUFS6/KLC1/CSNK1E/PPIF/UBE2L6/COX6B1/DNAI1/NDUFAB1/PSMD3/MCU/COX7A2L/NDUFB4/DNAH11/COX7A1/CDK5/ATG2B/CALM3/IL1B/NDUFA1/NDUFB11/MT-ATP6/FAS/PSMA2/ATP5PD/NDUFA8/WNT10B/ATP5PF/COX6A1/CAMK2G/DNALI1/PSEN2/CSNK2B/GRIN2D/COX6C/RYR2/COX5B/LRP5/ALS2/NDUFB2/FZD3/WNT9B/GRIA4/ATXN2L/NDUFA4L2/GPR37/ATP5F1E/CALML4/DNAH6/WNT16/TUBA3D/KIF5C/KIF5A/SNCA/HAP1/WNT3A/UCHL1	2.43352393741849
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	16/1503	55/9376	1.81474626504567	PLPP3/ASAH1/CERS6/SPTLC1/CERK/GM2A/HEXB/HEXA/SGPL1/CERS4/SPTLC2/PLPP1/GALC/SPHK1/SPTLC3/ACER1	2.64769205224335
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	37/1503	160/9376	1.44258150365935	NFASC/NECTIN2/HLA-DMA/CLDN4/CLDN20/CLDN10/PTPRD/CDH3/HLA-DPA1/ITGA6/SDC1/SELPLG/PVR/CLDN5/HLA-E/SDC2/CLDN3/OCLN/CDH2/CLDN23/NLGN4X/NEO1/NRXN1/SELE/CD86/ICAM2/NCAM2/CNTNAP2/HLA-A/SIGLEC1/SLITRK4/NRCAM/CLDN18/ESAM/CDH1/CLDN7/IGSF11	2.46704471446251
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	45/1503	204/9376	1.37607138663849	WNT5A/WNT4/WNT6/MMP9/LUM/PLAUR/VTN/PPP1CB/ERBB3/DCN/IGF2/MAPK14/WNT3/ESR1/ROCK2/MRAS/SDC1/WNT9A/CBL/SMAD2/CAV2/VEGFA/PRKACB/ANK3/SDC2/PIK3CB/RPS6KB2/HCLS1/KDR/CTSL/FAS/TIMP3/WNT10B/CAMK2G/THBS1/PAK1/IGF1/ITGB5/HOXD10/FZD3/WNT9B/WNT16/TLR2/WNT3A/ITGB3	2.37273018305599
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	36/1503	157/9376	1.43041305923185	WNT5A/WNT4/TGFBR1/ID1/NKD1/WNT6/CRB2/SERPINE1/PPP1CB/AREG/DLG5/WNT3/CTNNA3/WNT9A/SMAD2/TEAD1/CSNK1E/YWHAH/CCND3/BTRC/NKD2/PPP2R1B/WNT10B/BMP4/PARD6B/LEF1/FZD3/WNT9B/WWC1/CRB1/PARD3/PPP2R2B/WNT16/DLG2/WNT3A/CDH1	2.37622938052342
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1503	142/9376	1.44972027775435	MMP9/CALM2/CCL2/IL1R2/KLF2/MGST2/RAC2/MAPK14/MAPK7/MAP3K5/MEF2A/SDC1/MGST1/CAV2/VEGFA/CYBA/GSTA1/SDC2/PIK3CB/KDR/CTSL/CALM3/IL1B/ACVR2A/BMP4/SELE/THBD/PRKAA2/CALML4/NOS3/EDN1/ITGB3/NCF1	2.35931924398169
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1503	44/9376	1.843101675437	TUSC3/RPN1/RPN2/HEXB/B4GALT3/HEXA/ALG14/STT3A/KRTCAP2/MGAT4B/MAN1A1/ALG9/ALG1	2.44914178724632
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/1503	49/9376	1.78234008174128	LFNG/ST6GAL2/GALNT18/GALNT17/C1GALT1/EOGT/ST6GAL1/B4GALT3/GXYLT1/C1GALT1C1/GALNT15/POMT2/GALNT6/GALNT3	2.39893033093832
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1503	50/9376	1.74669328010645	KLRB1/CCL2/CD81/ACKR1/SDC1/SDC2/IL18/IL1B/THBS1/SELE/THBS4/CD36/TLR2/IL10	2.31299419217428
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/1503	19/9376	2.29828063171902	HEXB/GALNS/HEXA/SGSH/IDS/ARSB/GNS	2.4749821249089
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1503	110/9376	1.4744813403496	TGFBR1/ID1/ID3/SMAD9/CHRD/SMAD6/DCN/BAMBI/LEFTY2/SKP1/ZFYVE16/RBX1/LTBP1/SMAD2/ACVR1C/GREM2/NCOR1/RGMB/RPS6KB2/PPP2R1B/FST/ACVR2A/NEO1/THBS1/BMP4/E2F5	2.18707831862096
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1503	184/9376	1.35612832306402	WNT5A/SEMA3B/SEMA3A/WNT4/UNC5B/SEMA6D/SEMA3C/SEMA7A/UNC5C/NCK1/MYL12A/DPYSL2/RAC2/ABLIM2/CFL2/TRPC6/ABLIM3/ROCK2/MYL9/ROBO2/SEMA6A/EPHA2/PIK3CB/RGS3/CDK5/CAMK2G/NEO1/PAK1/PARD6B/FZD3/EPHB6/SEMA3G/SEMA4A/PLXNA4/PARD3/EPHA6/PLXNA2/SEMA3F/EPHB2/UNC5D	2.13159857453296
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1503	158/9376	1.38187759502093	WNT5A/WNT4/WNT6/DEPTOR/CAB39L/SGK1/RHEB/WNT3/RPS6KA2/CAB39/ATP6V1H/ATP6V1G1/WNT9A/ATP6V1E1/ATP6V1C1/ATP6V1F/PRR5/LAMTOR2/PIK3CB/RPS6KB2/LAMTOR5/WNT10B/LRP5/EIF4EBP1/IGF1/FZD3/GRB10/WNT9B/PRR5L/PRKAA2/WNT16/RRAGD/WNT3A/LPIN3/RPS6KA6	2.11509253850131
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1503	212/9376	1.32414416450119	CNR1/ID1/RASGRP2/CALM2/PDGFRA/PDGFD/TLN2/LPAR1/LCP2/RAC2/RAP1A/MAPK14/SIPA1L1/F2R/DOCK4/CTNND1/MRAS/AFDN/ADCY9/VEGFA/EPHA2/PRKD1/PDGFC/RAP1B/PIK3CB/KDR/CALM3/BCAR1/SIPA1L2/TEK/ANGPT1/THBS1/NGF/IGF1/PARD6B/PARD3/CALML4/ADCY2/RAPGEF3/ARAP3/LPAR5/PFN4/ITGB3/CDH1/FGF18	2.08573246197251
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	43/1503	203/9376	1.32139006060129	ITGA1/ITGA3/COL4A6/PDGFRA/PARVA/PDGFD/VTN/LAMA4/PPP1CB/MYLK/MYLK3/TLN2/MYL12A/EMP2/ACTN1/RAC2/LAMC3/RAP1A/ROCK2/ITGA6/MYL9/COL4A5/CAV2/VEGFA/PDGFC/RAP1B/PARVB/CCND3/PIK3CB/FLNB/KDR/BCAR1/COL4A4/THBS1/PAK1/IGF1/ITGB5/LAMB3/THBS4/RELN/COL4A3/ITGB3/SHC4	2.02264547160132
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	29/1503	128/9376	1.41333998669328	NUDT2/NUDT16/PNP/PDE4B/ENTPD3/FHIT/ENPP1/AK1/AK3/ADCY9/NME1/AK6/PDE3A/RRM1/ENTPD5/ENPP3/HPRT1/NPR1/PDE1A/ADK/AK9/ENPP4/HDDC3/PDE7B/DCK/ADCY2/GUCY1A1/PDE6B/AMPD3	2.05723307581749
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/1503	82/9376	1.5215098258767	KLRC1/B2M/CD74/HLA-DMA/KLRC3/KLRD1/KLRC2/HSPA1B/CTSB/HSPA2/HLA-DPA1/HLA-E/HSPA1A/IFI30/CTSL/TAPBPL/NFYA/RFXAP/HLA-A/CIITA	2.07234992810918
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	30/1503	134/9376	1.39660976554354	CALD1/CALM2/KCNMB4/KCNMA1/PPP1CB/MYLK/MYLK3/ACTA2/ADM/MYH10/ROCK2/RAMP3/MYL9/AVPR1A/ADCY9/PLA2G2A/PRKACB/RAMP1/NPR1/CALM3/KCNMB1/PTGIR/ACTG2/CALML4/KCNMB2/ADCY2/GUCY1A1/ADRA1B/EDN1/PRKCD	2.02035563514626
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	24/1503	103/9376	1.45355890161425	MME/SLC1A1/COL4A6/CPA1/COL14A1/CPB1/COL24A1/SLC7A8/COL26A1/PRCP/COL4A5/KCNE3/ATP1B3/COL27A1/COL4A4/SLC38A2/ELN/SLC7A7/COL4A3/COL19A1/COL25A1/PRSS3/COL23A1/COL28A1	2.02226087755429
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1503	48/9376	1.68950986915059	CLDN4/CLDN20/CLDN10/CD81/SCARB1/PDCD6IP/CLDN5/CLDN3/OCLN/EPCAM/CLDN23/CLDN18/CLDN7	2.09248252376103
NA	NA	hsa04519	Cadherin signaling	78/1503	404/9376	1.20440307503804	WNT5A/WNT4/KRT23/WNT6/PKP2/MPDZ/PDGFRA/PCDH20/DAAM1/LIMA1/PPP1CB/ACTN1/RAC2/KRT18/PCDH7/MAPK14/WNT3/MYO1D/CDH3/KRT81/GJA1/ARPC1B/PCDHB16/MYO1B/ROCK2/CTNND1/MRAS/CTNNA3/ADAM10/PSENEN/NCSTN/APH1B/WNT9A/AFDN/TEAD1/ERBIN/YWHAH/TMIE/KDR/KRT86/CDH11/PCDH19/DAAM2/CDH2/DSG2/APH1A/DES/WNT10B/WASF1/PSEN2/CDH13/FAT1/LRP5/LEF1/PCDH17/CDH20/FZD3/ACTR3B/WNT9B/CELSR1/CDH26/WWC1/WNT16/PCDHB6/PCDHGB6/CDH23/PCDHGB7/KRT17/PCDHGA2/WNT3A/PCDHB7/PCDHB11/PCDH9/CDH1/MYO7A/SCN1B/TMC7/PCDHGA1	1.83496792780022
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	36/1503	170/9376	1.32102853117295	MPDZ/CLDN4/CLDN20/CLDN10/MYL12A/ACTN1/SYNPO/RAP1A/MYH10/TUBA3E/ARPC1B/ROCK2/MAP3K5/MYL9/PRKAG1/AFDN/CLDN5/PRKACB/CLDN3/HCLS1/OCLN/PPP2R1B/NEDD4/CD1D/CLDN23/PARD6B/CGN/ACTR3B/PRKAA2/PARD3/PPP2R2B/TUBA3D/DLG2/EPB41L4B/CLDN18/CLDN7	1.84555762462367
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1503	65/9376	1.53555453196172	PLPP3/LCLAT1/DGKB/PNPLA2/PLPP5/AGPAT2/MBOAT2/AKR1B1/PLPP1/AGK/DGKE/LPL/GPAM/DGAT2/LPIN3/DGKA	1.89302877936448
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1503	51/9376	1.59012693567114	SEC61G/ATP6V0C/ATP6V0B/ATP6V1H/ATP6V1G1/ATP6V0E1/ATP6AP1/ATP6V1E1/ATP6V1C1/KDELR1/ATP6V1F/ADCY9/PRKACB	1.84629506368851
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	22/1503	98/9376	1.40041006422529	CALM2/IMPA2/IP6K3/DGKB/ITPKC/ITPK1/PPIP5K2/PI4KA/PLCD1/IMPA1/MTMR3/PIK3CB/MTMR6/CALM3/PLCD3/DGKE/PLCD4/ITPKB/CALML4/PIP4K2C/INPP4B/DGKA	1.74094816801169
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1503	10/9376	2.49527611443779	ETHE1/MPST/TST/SUOX	2.06699450457783
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	58/1503	298/9376	1.21414441809893	PRL/IL1RL1/TGFBR1/CCL3/TNFRSF21/CCL8/PRLR/CCL4/CCL23/CCL2/IL1R2/XCL2/XCL1/TNFRSF8/CXCL14/TNFRSF18/INHA/CCL21/LTBR/IL13RA1/GHR/CCL14/CSF3R/TNFRSF4/ACVR1C/LEPR/IL10RB/ACKR3/CLCF1/CXCL13/IL18/IL1B/CSF2RB/ACVR2A/FAS/OSM/TNFSF13B/ACKR4/IL2RA/BMP4/NGF/TNFSF10/IL7/TNFRSF12A/IL18R1/CCL28/TNFRSF19/CXCR3/CCL13/TNFSF14/IL34/CTF1/TNFRSF6B/IL11RA/CCR1/IL10/IL13RA2/IL23A	1.6414014175044
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1503	89/9376	1.4018405137291	ITGA1/ITGA3/COL4A6/VTN/LAMA4/FREM1/LAMC3/ITGA6/SDC1/COL4A5/COL4A4/THBS1/ITGB5/LAMB3/THBS4/RELN/CD36/COL4A3/ITGB3/SV2C	1.66420186240423
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	15/1503	63/9376	1.48528340145107	WNT5A/WNT4/WNT6/WNT3/WNT9A/SUFU/WNT10B/BMP4/LEF1/FZD3/WNT9B/KIF7/WNT16/GADD45G/WNT3A	1.68855772908492
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1503	33/9376	1.70132462348031	VAMP2/VAMP8/STX7/SNAP23/VAMP4/STX11/BET1L/VAMP7/STX6	1.76330681295801
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	31/1503	149/9376	1.29787851589885	CNR1/NDUFA4/NDUFS8/NDUFC2/MAPK14/NDUFA5/NDUFA3/MT-ND4/NDUFA7/GNB5/NDUFA13/NDUFB3/NDUFS2/NDUFS4/NDUFC1/ADCY9/NDUFS6/PRKACB/NDUFAB1/GNGT1/NDUFB4/NDUFA1/NDUFB11/NDUFA8/DAGLA/NDUFB2/GNG7/GRIA4/NDUFA4L2/ADCY2/ABHD6	1.60138980050298
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/1503	250/9376	1.22268529607452	RAB11FIP1/TGFBR1/WIPF1/RAB31/PDGFRA/GRK3/GRK5/HSPA1B/SMAP2/EHD4/CHMP5/PLD1/SMAP1/ARPC1B/CAPZA1/VPS37A/WASHC1/ZFYVE16/PDCD6IP/ASAP2/CBL/SMAD2/VPS37B/CLTB/SNX5/CAV2/CAPZA2/SNX4/RABEP1/RAB11B/STAMBP/HLA-E/HSPA1A/VPS29/RAB11FIP3/NEDD4/MVB12B/IL2RA/PARD6B/ACTR3B/ARF4/PARD3/DNAJC6/KIF5C/HLA-A/KIF5A/AGAP5/ARAP3/SH3GL2	1.55925202368782
Cellular Processes	Cell motility	hsa04814	Motor proteins	39/1503	194/9376	1.25406918122518	KIF26B/DNAH14/MYL12A/ACTA2/DYNLRB1/DYNLT3/MYH10/DCTN6/MYO1D/TUBA3E/CAPZA1/MYO1B/DCTN4/MYL9/TUBE1/CAPZA2/DYNLT1/TPM1/KLC1/KIF21A/DNAI1/DNAH11/DYNC1LI1/MYO10/KIF22/TUBG1/DNALI1/DYNC2H1/KIF13A/KIF18A/ACTG2/KIF7/DNAH6/TUBA3D/KIF5C/KIF5A/KIF23/KIFC1/MYO7A	1.56235316499623
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1503	101/9376	1.35881372568395	TGFBR1/COL4A6/F3/SERPINE1/CCL2/MAPK14/SMAD2/COL4A5/VEGFA/STAT1/PLCD1/PIK3CB/IL1B/PLCD3/COL4A4/SELE/PLCD4/THBD/COL4A3/NOS3/EDN1/PRKCD	1.58404596023593
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1503	15/9376	2.07939676203149	ST6GALNAC3/ST3GAL5/HEXB/HEXA/ST8SIA1	1.82793446179802
Organismal Systems	Sensory system	hsa04744	Phototransduction	8/1503	29/9376	1.72088007892261	CALM2/GNGT1/CALM3/CALML4/RCVRN/CNGA1/PDE6B/RGS9	1.69871649766417
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1503	44/9376	1.55954757152362	CCNH/MNAT1/GTF2H5/TAF3/GTF2A2/GTF2H2/TAF6/TAF4/TAF9B/GTF2H2C/TAF7L	1.62544018034405
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1503	157/9376	1.27147827487276	GULP1/ARG1/SGK1/ATP11A/VPS41/MFGE8/C1QB/MAPK14/C1QA/XKR6/ADAM10/ADAM9/PROS1/MERTK/ANO4/BCAR1/PTGER4/CAMK2G/THBS1/TYRO3/ITGB5/SLC66A1/C1QC/SPHK1/BSG/GPR132/CD36/MEGF10/IL10/ITGB3/SIGLEC10/ANO7	1.49878039034816
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/1503	86/9376	1.37820483064878	SGCE/ITGA1/PKP2/ITGA3/GJA1/CTNNA3/ITGA6/SGCZ/DMD/CACNA2D3/SGCB/CDH2/DSG2/DES/RYR2/ITGB5/LEF1/SNTB1/ITGB3	1.5394423967451
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	49/1503	254/9376	1.20343040952216	CALM2/PDGFRA/PDGFD/MYLK/MYLK3/ERBB3/ITPKC/ATP2B4/F2R/HTR2B/SLC25A4/EDNRB/CACNA1G/AVPR1A/ADCY9/NTRK1/VEGFA/PLCD1/PDGFC/PPIF/HTR2A/ATP2B3/PRKACB/PHKG1/MCU/KDR/PHKA1/PDE1A/CALM3/PLCD3/CAMK2G/GRIN2D/RYR2/NGF/CACNA1H/PTGER3/RET/CYSLTR1/PLCD4/TACR1/ITPKB/SPHK1/GNA15/CALML4/ADCY2/OXTR/NOS3/ADRA1B/FGF18	1.43609344703127
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1503	50/9376	1.49716566866267	MAOB/ARG1/MAOA/SAT1/SMOX/CKB/PYCR2/P4HA3/GOT2/CKMT2/GAMT/NOS3	1.54004506910959
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/1503	78/9376	1.35960557517444	IMPA2/IP6K3/ITPKC/ITPK1/PPIP5K2/PI4KA/FIG4/PLCD1/IMPA1/MTMR3/PIK3CB/MTMR6/PLCD3/PLCD4/ITPKB/PIP4K2C/INPP4B	1.39339404270728
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/1503	36/9376	1.55954757152362	ST6GALNAC3/GALNT18/GALNT17/C1GALT1/C1GALT1C1/GALNT15/ST6GALNAC2/GALNT6/GALNT3	1.46963616380531
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	35/1503	178/9376	1.22661044951296	WNT5A/LGR4/WNT4/NKD1/WNT6/DAAM1/DKK1/RAC2/BAMBI/WNT3/SKP1/ROCK2/RBX1/WNT9A/TLE6/TLE2/CSNK1E/PRKACB/CCND3/BTRC/NKD2/DAAM2/WNT10B/CAMK2G/CSNK2B/LRP5/LEF1/FZD3/WNT9B/CELSR1/WNT16/RSPO1/TBL1X/MCC/WNT3A	1.33363883532987
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1503	12/9376	2.07939676203149	VKORC1L1/COQ2/VKORC1/HPD	1.63469236503624
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1503	79/9376	1.34239537802033	SLC1A1/SYT1/VAMP2/ATP6V0C/ATP6V0B/SLC1A2/ATP6V1H/ATP6V1G1/ATP6V0E1/ATP6V1E1/CLTB/ATP6V1C1/ATP6V1F/STXBP1/NAPA/UNC13B/SLC1A3	1.33525750131315
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1503	101/9376	1.29704946542558	WNT5A/WNT4/WNT6/CALM2/WNT3/WNT9A/MITF/EDNRB/ADCY9/PRKACB/CALM3/WNT10B/CAMK2G/LEF1/FZD3/WNT9B/CALML4/WNT16/ADCY2/WNT3A/EDN1	1.31137682874513
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1503	140/9376	1.2476380572189	TGFBR1/PLIN1/CALM2/SERPINE1/MYLK/MYLK3/KLF2/ACTA2/GNB5/MRAS/MEF2A/SMAD2/HDAC4/PRKAG1/ADCY9/PRKACB/GNGT1/RPS6KB2/CALM3/RYR2/GNG7/SPHK1/PRKAA2/CALML4/ADCY2/NOS3/PPARGC1A/CDH1	1.28983585904349
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1503	63/9376	1.386264508021	POLR2K/CCNH/MNAT1/POLE4/POLR2I/POLR2J/GTF2H5/RAD23A/POLR2L/RBX1/POLD4/GTF2H2/RFC3/GTF2H2C	1.34401860549892
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1503	17/9376	1.83476184885132	PCDH20/PCDH7/MYH10/NRP2/PCDH9	1.50510684928724
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1503	37/9376	1.51739763715812	ALDH5A1/GLUL/RIMKLB/GFPT1/NIT2/GOT2/CPS1/GLUD2/ASNS	1.37774904341262
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/1503	27/9376	1.61730859269116	ACAT2/ALDH5A1/OXCT1/BDH1/ACADS/ACSM6/OXCT2	1.40344897339932
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1503	69/9376	1.35612832306402	REN/CALM2/KCNMA1/CTSB/PDE3A/PRKACB/NPR1/PDE1A/CALM3/PTGER4/PRKG2/AQP1/CALML4/GUCY1A1/EDN1	1.29724261167521
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/1503	48/9376	1.42958527389665	HIBADH/ACAT2/AUH/MCEE/HIBCH/OXCT1/MCCC1/ACADM/ACSF3/ACADS/OXCT2	1.30367920505794
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/1503	193/9376	1.19592249008029	CCL3/CCL8/RASGRP2/CCL4/CCL23/CCL2/XCL2/XCL1/GRK3/GRK5/CXCL14/RAC2/ITK/RAP1A/GNB5/CCL21/ROCK2/CCL14/ADCY9/STAT1/RAP1B/PRKACB/GNGT1/PIK3CB/CXCL13/BCAR1/PAK1/GNG7/CCL28/CXCR3/PARD3/CCL13/ADCY2/CCR1/NCF1/SHC4/PRKCD	1.20161587393947
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1503	97/9376	1.28622480125659	NOS1AP/CALM2/PER3/GNB5/CACNA1G/ADCY9/PER1/PRKACB/GNGT1/CALM3/CAMK2G/GRIN2D/RYR2/PRKG2/CACNA1H/GNG7/GRIA4/CALML4/ADCY2/GUCY1A1	1.23804817706734
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1503	75/9376	1.33081392770016	IGFBP3/SERPINE1/CD82/AIFM2/SESN1/RPRM/RCHY1/EI24/CCND3/FAS/PERP/THBS1/IGF1/TP53I3/STEAP3/GADD45G	1.25673756844749
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	10/1503	43/9376	1.45074192699872	APOA1/PLPP3/SCARB1/ACAT2/PLA2G2A/AGPAT2/PLPP1/GOT2/CD36/DGAT2	1.29433458168523
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	61/1503	333/9376	1.1427315539092	WNT5A/ISG15/WNT4/MAML3/ITGA1/WNT6/LFNG/ITGA3/COL4A6/VTN/LAMA4/RHEB/MX1/BCAP31/ATP6V0C/LAMC3/ATP6V0B/WNT3/ATP6V1H/ATP6V1G1/ATP6V0E1/ITGA6/ATP6AP1/WNT9A/ATP6V1E1/COL4A5/ATP6V1C1/ATP6V1F/VEGFA/IRF9/STAT1/HLA-E/PRKACB/EIF2AK2/HES4/CCND3/PIK3CB/RPS6KB2/PPP2R1B/FAS/PTGER4/WNT10B/TUBG1/COL4A4/THBS1/EIF4EBP1/ITGB5/PARD6B/FZD3/WNT9B/LAMB3/THBS4/RELN/PARD3/PPP2R2B/WNT16/HLA-A/COL4A3/DLG2/WNT3A/ITGB3	1.15872625638943
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	38/1503	200/9376	1.18525615435795	WIPF1/CLDN4/CLDN20/CLDN10/NCK1/ABI1/LPAR1/TMBIM6/MAPK14/MYH10/MYO1D/TUBA3E/ARPC1B/F2R/MYO1B/ROCK2/TMED10/SEC24B/RAB1A/CLDN5/IRAK4/CLDN3/HCLS1/OCLN/IL18/IL1B/FAS/CLDN23/MYO10/WASF1/PAK1/TNFSF10/ACTR3B/TUBA3D/LPAR5/CLDN18/WASF3/CLDN7	1.15706016661597
Organismal Systems	Immune system	hsa04611	Platelet activation	25/1503	126/9376	1.23773616787589	RASGRP2/FCER1G/PPP1CB/MYLK/MYLK3/TLN2/MYL12A/LCP2/RAP1A/MAPK14/VAMP8/F2R/ROCK2/SNAP23/ADCY9/RAP1B/PRKACB/PIK3CB/PTGIR/PRKG2/FGG/ADCY2/GUCY1A1/NOS3/ITGB3	1.17382854628701
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1503	28/9376	1.55954757152362	HACD1/TECR/ELOVL1/ACOT7/HACD2/THEM4/ELOVL4	1.29554255160583
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1503	28/9376	1.55954757152362	PCBD1/MOCS2/PTS/AKR1B1/PCBD2/TH/MOCOS	1.29554255160583
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/1503	23/9376	1.62735398767682	ARG1/GLUL/GOT2/CPS1/NOS3/GLUD2	1.31612190216437
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1503	44/9376	1.41777051956693	ARHGDIB/VAMP2/DCTN6/DCTN4/ADCY9/RAB11B/PRKACB/DYNC1LI1/DYNC2H1/AQP3	1.21358937689291
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1503	99/9376	1.26024046183727	CALM2/PPP1CB/MAPK14/HTR2B/ADCY9/NTRK1/HTR2A/PRKACB/PIK3CB/CALM3/IL1B/PTGER4/CAMK2G/NGF/IGF1/CALML4/ADCY2/CYP2J2/ASIC3/PRKCD	1.13732253079169
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1503	99/9376	1.26024046183727	PLPP3/PDGFRA/PDGFD/CHPT1/RHEB/RAC2/DGKB/PLD1/SLC44A2/SLC44A1/PDGFC/PIK3CB/RPS6KB2/PLPP1/WASF1/DGKE/EIF4EBP1/DGKA/WASF3/SLC44A5	1.13732253079169
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1503	61/9376	1.32945038883981	SLC40A1/ATP2B4/HMOX2/FTH1/ATP2B3/MT1X/SLC39A4/ATP1B3/ATOX1/SLC46A1/MT1A/ATP7B/TRPM6	1.12786862367416
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1503	14/9376	1.78234008174128	B4GALT3/B3GNT2/B4GALT4/CHST1	1.27988303742611
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1503	30/9376	1.45557773342204	GPLD1/PIGP/PIGX/PIGC/PIGT/PIGU/DPM2	1.09195623230759
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	24/1503	125/9376	1.19773253493014	CTSD/FCER1G/ASAH1/CERS6/RAC2/MAPK14/SPTLC1/PLD1/ORMDL2/ABCC1/ROCK2/ORMDL1/MAP3K5/MS4A2/SGPL1/CERS4/PIK3CB/PPP2R1B/SPTLC2/SPHK1/PPP2R2B/SPTLC3/ACER1/NOS3	0.972375041084966
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	31/1503	166/9376	1.16496324619837	CALM2/KCNMB4/KCNMA1/PPP1CB/MYLK/MYLK3/TRPC6/ATP2B4/ROCK2/SLC25A4/MEF2A/KCNJ8/RGS2/MYL9/EDNRB/ADCY9/PPIF/PDE3A/ATP2B3/NPR1/CALM3/KCNMB1/ATP1B3/PRKG2/CALML4/KCNMB2/ADCY2/GUCY1A1/NOS3/ADRA1B/CNGA1	0.93692844853389
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1503	20/9376	1.55954757152362	CYB5R3/CYB5R1/UGDH/CMAS/TGDS	1.09446507929531
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1503	138/9376	1.17531121332215	SPDYE2/CALM2/CPEB4/PPP1CB/MAPK14/SKP1/RPS6KA2/RBX1/ANAPC10/ADCY9/PRKACB/SPDYA/YWHAH/ANAPC15/BTRC/PPP2R1B/CALM3/CAMK2G/IGF1/SPDYE5/CALML4/ADCY2/PTTG1/MAD2L1/SMC1B/RPS6KA6	0.906473813354714
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1503	98/9376	1.2094450554673	PLPP3/RAC2/CFL2/PLD1/ARPC1B/ASAP2/PIK3CB/RPS6KB2/MYO10/PLPP1/WASF1/PAK1/ACTR3B/SPHK1/SCIN/FCGR3A/NCF1/WASF3/PRKCD	0.910648902695252
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1503	87/9376	1.21895672257019	MT-CO2/UQCR11/UQCR10/COX7B/COX8A/UQCRQ/COX7A2/TPM1/CACNA2D3/COX6B1/COX7A2L/COX7A1/ATP1B3/COX6A1/COX6C/RYR2/COX5B	0.896454871097703
Organismal Systems	Digestive system	hsa04970	Salivary secretion	18/1503	93/9376	1.20739166827635	CAMP/CALM2/BST1/KCNMA1/VAMP2/ATP2B4/SLC4A2/ADCY9/ATP2B3/PRKACB/CALM3/ATP1B3/CST2/PRKG2/CALML4/ADCY2/GUCY1A1/ADRA1B	0.87818013112183
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1503	76/9376	1.23122176699233	APOA1/APOC3/PLIN1/SORBS1/FABP5/ANGPTL4/ACADM/FABP4/CYP27A1/PLTP/OLR1/SLC27A6/LPL/SLC27A5/CD36	0.884278448060283
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	8/1503	37/9376	1.3487978996961	MAOB/MAOA/COMT/TH/FAH/GOT2/ADH1C/HPD	0.92879429308986
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	33/1503	181/9376	1.13734961017192	CTSD/CAMP/CD74/CALM2/FCER1G/HLA-DMA/CORO1A/ATP6V0C/C3/ATP6V0B/MAPK14/HLA-DPA1/ATP6V1H/MRC2/ATP6AP1/PLA2R1/IL10RB/STAT1/IRAK4/CALM3/IL18/IL1B/PLK3/CAMK2G/NFYA/SPHK1/RFXAP/CALML4/FCGR3A/TLR2/CIITA/IL10/IL23A	0.815240702514467
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1503	21/9376	1.48528340145107	CHSY1/CHST3/CHPF/B3GAT3/CHST7	0.972698377057313
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1503	16/9376	1.55954757152362	MAOB/MAOA/GOT2/HPD	0.978710133373253
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1503	27/9376	1.386264508021	HACD1/TECR/ELOVL1/ACOT7/HACD2/ELOVL4	0.878171037405067
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/1503	78/9376	1.19965197809509	SERPING1/CALM2/CFL2/C1QB/C3/MAPK14/C1QA/IRAK4/CALM3/IL1B/C1QC/LY96/CALML4/IL10/IL23A	0.773608353422992
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	28/1503	154/9376	1.13421641565354	DHRS3/MOCS2/PTS/CMPK1/VKORC1L1/AK1/AK3/NME1/MMAB/AK6/HSD17B6/ALAD/UGDH/COQ2/MTHFD2L/AK9/COX10/RGN/CMPK2/PPOX/CTPS2/VKORC1/NMNAT3/UMPS/KMO/LIPT2/PANK1/HPD	0.733750551595396
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1503	44/9376	1.27599346761023	POLE4/PARP4/UNG/SMUG1/POLD4/POLB/OGG1/RFC3/POLG2	0.801738573441779
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1503	120/9376	1.14366821911732	CALM2/ARHGDIB/RAP1A/MAPK14/MAPK7/RPS6KA2/MAP3K5/MATK/NTRK1/RAP1B/IRAK4/PIK3CB/CALM3/CAMK2G/PSEN2/NGF/NFKBIE/SORT1/CALML4/SHC4/PRKCD/RPS6KA6	0.692045519415256
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1503	62/9376	1.20739166827635	MAML3/LFNG/PSENEN/NCSTN/APH1B/TLE6/KAT2B/TLE2/APH1A/DTX3L/PSEN2/DTX3	0.715836824466717
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1503	17/9376	1.46780947908105	CYP39A1/CYP7B1/CYP27A1/SLC27A5	0.843477995664603
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1503	17/9376	1.46780947908105	GLUL/CA12/CPS1/GLUD2	0.843477995664603
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1503	28/9376	1.33675506130596	B4GALT3/B3GNT2/ST3GAL6/B4GALT4/B3GNT5/ST8SIA1	0.779702269464829
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1503	28/9376	1.33675506130596	ATP6V0C/ATP6V1G1/ATP6V0E1/ATP6V1E1/ATP6V1C1/ATP6V1F	0.779702269464829
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/1503	103/9376	1.15073413044461	TGFBR1/CCL3/SERPINE1/CCL2/C1QB/C3/MAPK14/C1QA/SMAD2/IRAK4/PIK3CB/PPP2R1B/IL1B/FAS/C1QC/GNA15/PPP2R2B/TLR2/IL10	0.672070890518114
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/1503	45/9376	1.2476380572189	ABCC1/ABCB8/ABCB7/ABCC9/ABCA3/ABCC3/ABCD3/ABCC8/ABCA13	0.727536109167957
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/1503	45/9376	1.2476380572189	KLRC1/HLA-DMA/KLRD1/HLA-DPA1/HLA-E/IL1B/FAS/CD86/HLA-A	0.727536109167957
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1503	109/9376	1.14462207084302	PPP1CB/TBC1D4/ACACB/RPS6KA2/PRKAG1/GFPT1/PYGL/PIK3CB/RPS6KB2/G6PC3/SLC27A6/SLC27A5/PRKAA2/PPP1R3D/CD36/NOS3/PPARGC1A/PRKCD/PPP1R3C/RPS6KA6	0.663549377582444
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1503	23/9376	1.35612832306402	REN/MME/PRCP/CTSA/NLN	0.747119322061396
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1503	116/9376	1.12932755179297	SLC1A1/HOMER2/GRM7/GRK3/GLUL/PLD1/SLC1A2/GNB5/ADCY9/PRKACB/GNGT1/GRIK2/GRIK1/GRIN2D/SLC38A2/GNG7/GRIA4/HOMER1/SLC1A3/ADCY2/SHANK3	0.612363871901456
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	18/1503	99/9376	1.13421641565354	SGCE/ITGA1/ITGA3/ITGA6/PRKAG1/SGCZ/DMD/TPM1/CACNA2D3/SGCB/DES/RYR2/IGF1/ITGB5/PRKAA2/SNTB1/EDN1/ITGB3	0.586562721443092
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1503	18/9376	1.386264508021	AGA/HEXB/HEXA/FUCA2	0.716678769986692
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1503	18/9376	1.386264508021	CD320/MMADHC/MMAB/MTR	0.716678769986692
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1503	100/9376	1.12287425149701	MME/ITGA1/ITGA3/HLA-DMA/IL1R2/CD7/HLA-DPA1/ITGA6/CD37/CSF3R/CD59/IL1B/CD1D/IL2RA/IL7/CD36/IL11RA/ITGB3	0.539728707273288
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1503	130/9376	1.10367981984748	TGFBR1/MMP9/COL4A6/RXFP1/ACTA2/MAPK14/GNB5/SMAD2/COL4A5/EDNRB/ADCY9/VEGFA/PRKACB/GNGT1/PIK3CB/COL4A4/GNG7/GNA15/COL4A3/ADCY2/NOS3/EDN1/SHC4	0.520096544414321
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	25/1503	142/9376	1.09827293769269	UBE2W/KLHL13/UBE2M/SKP1/ELOB/RBX1/CBL/ANAPC10/UBE2K/UBA6/UBE2N/UBE4B/UBE3C/RCHY1/UBE2D1/UBE2L6/ANAPC15/BTRC/NEDD4/UBA3/FBXW7/UBE2D4/PIAS3/UBE2QL1/UBE2C	0.515558769595048
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1503	59/9376	1.163052426221	PLIN1/PNPLA2/ADCY9/ABHD5/PRKACB/PIK3CB/NPR1/PRKG2/FABP4/PTGER3/ADCY2	0.548921480923025
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1503	71/9376	1.1422038552004	ATP6V0C/ATP6V0B/MAPK14/ATP6V1H/ATP6V1G1/ATP6V0E1/ADAM10/ATP6AP1/ATP6V1E1/ATP6V1C1/ATP6V1F/PAK1/PTPRZ1	0.52550561262462
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1503	89/9376	1.12147241098328	PDGFRA/PDGFD/LPAR1/MAPK7/GJA1/TUBA3E/MAP3K2/HTR2B/ADCY9/PDGFC/HTR2A/PRKACB/PRKG2/TUBA3D/ADCY2/GUCY1A1	0.503071755291914
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1503	54/9376	1.15522042335083	CISD1/MDH2/MTR/ADI1/MPST/TST/GOT2/MRI1/BHMT2/CDO1	0.499788428746989
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1503	78/9376	1.11967517955542	ARHGEF26/ARPC1B/CTNNA3/CBL/CLTB/CAV2/PIK3CB/HCLS1/BCAR1/WASF1/SEPTIN1/ACTR3B/SHC4/CDH1	0.46371550878085
NA	NA	hsa04382	Cornified envelope formation	37/1503	217/9376	1.06365456491012	KRT23/PKP2/COL4A6/S100A1/CLDN4/CLDN20/CLDN10/KRT18/SPTLC1/KRT81/ITGA6/S100A6/COL4A5/ELOVL1/ABHD5/CLDN5/CLDN3/OCLN/PPP2R1B/KRT86/SPTLC2/CLDN23/DSG2/COL4A4/TGM1/S100A2/LAMB3/KAZN/S100A11/PPP2R2B/ELOVL4/CDSN/SPTLC3/COL4A3/KRT17/CLDN18/CLDN7	0.414505592290256
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1503	31/9376	1.20739166827635	PGD/RBKS/H6PD/DERA/ALDOC/RGN	0.505332815978596
NA	NA	hsa04981	Folate transport and metabolism	6/1503	31/9376	1.20739166827635	ABCC1/MTHFS/MTR/ABCC3/BHMT2/SLC46A1	0.505332815978596
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1503	37/9376	1.18019816223409	APOA1/LAMA4/IL18/IL1B/FAS/SELE/IL10	0.479839542767103
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1503	37/9376	1.18019816223409	CCDC6/TFG/NTRK1/LEF1/RET/GADD45G/CDH1	0.479839542767103
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1503	73/9376	1.11091059889354	BST2/SMARCB1/MDFIC/MX1/PIN1/RANBP2/PDCD6IP/KAT2B/BICD1/SERINC3/SERINC5/SUPT4H1/BICD2	0.415640609256615
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1503	67/9376	1.11728781243483	CALM2/PPP1CB/RAP1A/RPS6KA2/RAP1B/PRKACB/CALM3/CAMK2G/GRIN2D/CALML4/RAPGEF3/RPS6KA6	0.420953161138912
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1503	98/9376	1.08213504962863	CALM2/SCARB1/ATP2B4/CACNA1G/ADCY9/PRKD1/ATP2B3/PRKACB/NPR1/CALM3/ATP1B3/CAMK2G/KCNK3/CACNA1H/DAGLA/CALML4/ADCY2	0.357116059150961
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1503	26/9376	1.19965197809509	APOA1/SCARB1/BTD/ABCC1/SLC46A1	0.445399257529486
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1503	62/9376	1.10677569591999	HSPA1B/PRKAG1/ADCY9/HSPA1A/PRKACB/PIK3CB/RPS6KB2/CRYAB/IGF1/PRKAA2/ADCY2	0.368548918733511
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1503	32/9376	1.16966067864271	ATG9B/GABARAPL2/GABARAP/ATG2B/ATG4A/ATG4D	0.420034319887561
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1503	38/9376	1.14914031585951	HEXB/HEXA/GFPT1/UGDH/UXS1/NAGK/AMDHD2	0.40248984260944
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1503	38/9376	1.14914031585951	BST1/PNP/ENPP1/NUDT12/ENPP3/NMNAT3/NMRK1	0.40248984260944
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	60/1503	362/9376	1.03395419106538	PRL/ITGA1/PRLR/ITGA3/COL4A6/PDGFRA/SGK1/PDGFD/VTN/LAMA4/RHEB/LPAR1/ERBB3/AREG/LAMC3/IGF2/GNB5/F2R/ITGA6/GHR/CSF3R/COL4A5/NTRK1/VEGFA/EPHA2/PDGFC/GNGT1/YWHAH/CCND3/PIK3CB/RPS6KB2/G6PC3/KDR/PPP2R1B/OSM/TEK/COL4A4/PIK3AP1/ANGPT1/THBS1/IL2RA/NGF/EIF4EBP1/IGF1/ITGB5/IL7/RET/GNG7/LAMB3/THEM4/PRKAA2/THBS4/RELN/PPP2R2B/TLR2/COL4A3/NOS3/LPAR5/ITGB3/FGF18	0.287861708947153
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/1503	44/9376	1.13421641565354	HLA-DMA/HLA-DPA1/HLA-E/IL1B/FAS/CD86/CPE/HLA-A	0.389887769990644
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/1503	105/9376	1.06940404904477	SGCE/ITGA1/ITGA3/ITGA6/ADCY9/SGCZ/DMD/TPM1/CACNA2D3/PRKACB/SGCB/DES/RYR2/IGF1/ITGB5/SNTB1/ADCY2/ITGB3	0.31247204506224
Human Diseases	Infectious disease: viral	hsa05162	Measles	23/1503	136/9376	1.05498806308951	HSPA1B/MX1/CD46/IFIH1/IRF7/IRF9/STAT1/RCHY1/HSPA1A/IRAK4/EIF2AK2/CCND3/PIK3CB/OAS3/IL1B/FAS/CSNK2B/IL2RA/OAS2/OAS1/TLR2/TLR7/TNFAIP3	0.282225917528204
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/1503	173/9376	1.04570819824705	CCL2/HLA-DMA/KPNA1/MX1/HLA-DPA1/SLC25A4/IFIH1/RSAD2/IRF7/IRF9/STAT1/RAB11B/IRAK4/EIF2AK2/CCND3/PIK3CB/OAS3/IL18/IL1B/FAS/NXT1/TNFSF10/OAS2/OAS1/TMPRSS11D/NXT2/CIITA/TLR7/PRSS3	0.265123024607076
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1503	57/9376	1.09441934843763	ACAT2/HACD1/TECR/ELOVL1/ACADM/ACSF3/HACD2/ACADS/ELOVL4/MCAT	0.31239838057728
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1503	149/9376	1.04667622249907	PLPP3/GRM7/FCER1G/PDGFRA/PDGFD/RHEB/LPAR1/DGKB/PLD1/F2R/MRAS/AVPR1A/MS4A2/ADCY9/PDGFC/AGPAT2/PIK3CB/PLPP1/DGKE/SPHK1/ADCY2/RAPGEF3/LPAR5/DGKA/SHC4	0.250930572856101
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/1503	39/9376	1.11967517955542	HLA-DMA/HLA-DPA1/HLA-E/FAS/CD86/HLA-A/IL10	0.327210864016729
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/1503	180/9376	1.03969838101575	BST2/B2M/CD74/NECTIN2/CCL2/HLA-DMA/PPP1CB/RHEB/C3/HLA-DPA1/IFIH1/IRF7/IRF9/STAT1/HLA-E/IRAK4/EIF2AK2/PIK3CB/OAS3/ALYREF/IL1B/FAS/TAPBPL/EIF4EBP1/OAS2/OAS1/TNFSF14/TLR2/HLA-A/ITGB3	0.2349657544097
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1503	156/9376	1.03969838101575	CLDN4/CLDN20/CLDN10/CD81/MX1/SCARB1/RSAD2/IRF7/IRF9/IFIT1/STAT1/CLDN5/CLDN3/EIF2AK2/YWHAH/PIK3CB/OAS3/OCLN/PPP2R1B/FAS/CLDN23/OAS2/OAS1/PPP2R2B/CLDN18/CLDN7	0.218456331877548
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	24/1503	144/9376	1.03969838101575	WNT5A/WNT4/ID1/ID3/WNT6/SMAD9/MAPK14/WNT3/LEFTY2/WNT9A/SMAD2/ACVR1C/SMARCAD1/TBX3/PIK3CB/MEIS1/ACVR2A/WNT10B/BMP4/IGF1/FZD3/WNT9B/WNT16/WNT3A	0.209749602560227
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/1503	138/9376	1.03969838101575	CALM2/SORBS1/PPP1CB/RHEB/ACACB/CBL/PRKAG1/PYGL/PRKACB/PHKG1/PRKAR2B/PIK3CB/RPS6KB2/G6PC3/PHKA1/CALM3/EIF4EBP1/PRKAA2/PPP1R3D/CALML4/PPARGC1A/SHC4/PPP1R3C	0.205266634925546
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/1503	157/9376	1.03307609833412	IGFBP3/TGFBR1/CALM2/SERPINE1/PPP1CB/RHEB/MAPK14/MRAS/SLC25A4/NBN/RBBP4/SMAD2/HLA-E/MCU/CCND3/PIK3CB/BTRC/LIN52/CALM3/EIF4EBP1/LIN37/CALML4/E2F5/GADD45G/HLA-A/LIN9	0.182606905085269
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1503	34/9376	1.10085710931079	POLR2K/POLR3GL/POLR2I/POLR2J/POLR2L/POLR3K	0.257407410947124
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1503	158/9376	1.02653764201555	CDKN1C/CDKN2C/CCNH/ORC3/SKP1/CDC7/RBX1/ANAPC10/SMAD2/PDS5A/MTBP/YWHAH/ANAPC15/CCND3/TRIP13/PPP2R1B/WEE1/ORC6/E2F5/GADD45G/MAD2L1BP/PTTG1/CDCA5/MAD2L1/SMC1B/MCM2	0.146983141583433
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1503	59/9376	1.05732038747364	GGT5/PGD/MGST2/GPX4/GPX8/TXNDC12/MGST1/RRM1/GSTA1/CHAC2	0.192971013730668
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1503	16/9376	1.16966067864271	HEXB/HEXA/ST8SIA1	0.296755153400927
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1503	103/9376	1.02960422197676	ARG1/COL4A6/IL1R2/LAMA4/ACTN1/LAMC3/COL4A5/PRKACB/PIK3CB/IL1B/CD1D/COL4A4/LAMB3/GNA15/TLR2/COL4A3/IL10	0.131994895703643
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1503	66/9376	1.03969838101575	STAT4/HLA-DMA/HLA-DPA1/SMAD2/STAT1/IL18/IL1B/IL18R1/TLR2/IL10/IL23A	0.141405051961653
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/1503	104/9376	1.01970418138083	PLPP3/CHPT1/LCLAT1/DGKB/PLD1/PLPP5/PISD/PLA2G2A/AGPAT2/MBOAT2/PLPP1/DGKE/GDPD5/PLD4/GPAM/LPIN3/DGKA	0.0882842755420101
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1503	23/9376	1.08490265845121	B4GALT3/CRPPA/LARGE1/POMT2	0.178116741958427
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1503	17/9376	1.10085710931079	MTR/TXNRD3/INMT	0.181849142041971
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1503	36/9376	1.03969838101575	ENPP1/GAA/PYGL/ENPP3/G6PC3/PGM2L1	0.104266695727765
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/1503	99/9376	1.00819236946981	CFH/KRT23/CAMP/HLA-DMA/MASP1/C1QB/KRT18/C3/C1QA/HLA-DPA1/SELPLG/FGG/C1QC/FCGR3A/KRT17/IL10	0.0358029120944935
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/1503	137/9376	1.00175318462831	CTSD/PTPN13/CTSB/CTSZ/TUBA3E/MAP3K5/PARP4/CTSO/DAB2IP/NTRK1/PIK3CB/CTSL/CSF2RB/FAS/NOL3/CTSK/NGF/TNFSF10/TUBA3D/GADD45G/BCL2A1/DIABLO	0.00903171982871386
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1503	49/9376	1.0184800467093	MAOB/MAOA/GPSM1/PRKACB/CDK5/TH/GRIN2D/RGS9	0.0566663342486947
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1503	30/9376	1.03969838101575	ABCC1/MTR/ABCC3/IL1B/SLC46A1	0.0951514777446494
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1503	24/9376	1.03969838101575	EXT2/B3GAT3/HS6ST2/HS3ST3B1	0.0850787636580178
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1503	56/9376	1.00256629597947	GRK3/GAS1/DISP1/SUFU/CSNK1E/PRKACB/BTRC/KIF7/CDON	0.00841565268233246
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1503	37/9376	1.01159842477208	GFPT1/UGDH/UXS1/NAGK/CMAS/TGDS	0.0308847924443451
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1503	69/9376	0.994494103580279	MAOB/MAOA/CALM2/PPP1CB/PRKACB/CALM3/TH/CAMK2G/GRIN2D/GRIA4/CALML4	-0.0200559264415712
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1503	82/9376	0.988981386819856	UPP1/CDA/MGST2/CMPK1/MGST1/NME1/RRM1/GSTA1/HPRT1/TK2/UMPS/CYP2A6/UPP2	-0.0437852195658003
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1503	63/9376	0.990188934300711	ACAT2/SMYD3/SETD7/PLOD1/SETDB2/AASS/SMYD2/DHTKD1/SETMAR/SUV39H1	-0.0341378888450719
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1503	18/9376	1.03969838101575	ACACB/ACSF3/MCAT	0.073656746312508
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1503	31/9376	1.00615972356363	ACAT2/GLUL/MCEE/ACSS1/MDH2	0.0150088500658034
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1503	108/9376	0.981937359848205	KPNA1/RBM8A/RANBP2/RANGAP1/TMEM33/RANBP17/XPO4/NUP160/ALYREF/NXT1/UPF3B/AAAS/MAGOHB/NUP133/NUP35/THOC3/NXT2	-0.0824888212864053
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1503	70/9376	0.980287044957704	SGCE/HLA-DMA/RAC2/HLA-DPA1/SGCZ/DMD/HLA-E/SGCB/CD86/SNTB1/HLA-A	-0.072329294687138
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1503	51/9376	0.978539652720702	PLA2G7/PLPP3/CHPT1/PLD1/PLA2G2A/PLPP1/PLD4/PAFAH1B3	-0.0671417128278457
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/1503	122/9376	0.97152143799832	WNT4/RHEB/TBC1D4/ESR1/KAT2B/STAT1/PLCD1/MED14/NCOR1/PRKACB/PIK3CB/ATP1B3/PLCD3/BMP4/PLCD4/RCAN2/MED12L/DIO3/ITGB3	-0.138333774413896
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1503	300/9376	0.977316478154802	TGFBR1/RASGRP2/PDGFRA/PDGFD/HSPA1B/STMN1/ERBB3/RAC2/AREG/RAP1A/IGF2/MAPK14/MAPK7/MAP3K2/RPS6KA2/MAP4K3/MRAS/MAP3K5/CACNA1G/MAP3K4/MAP3K13/NTRK1/VEGFA/EPHA2/MAP3K20/CACNA2D3/PDGFC/RAP1B/HSPA1A/IRAK4/PRKACB/PPP5C/KDR/IL1B/FAS/TEK/ANGPT1/PAK1/NGF/PTPN7/IGF1/CACNA1H/RET/DUSP10/GADD45G/RPS6KA6/FGF18	-0.174469240529211
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1503	12/9376	1.03969838101575	CD46/NCAM2	0.0601212108776428
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1503	32/9376	0.974717232202262	ACACB/MCEE/HIBCH/ACSS1/ACADS	-0.062593349630303
Human Diseases	Immune disease	hsa05310	Asthma	5/1503	32/9376	0.974717232202262	FCER1G/HLA-DMA/HLA-DPA1/MS4A2/IL10	-0.062593349630303
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1503	19/9376	0.984977413593865	DLAT/DHTKD1/LIPT2	-0.0286383636300988
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1503	155/9376	0.96591333462108	WNT5A/WNT4/WNT6/CDKN2C/KCNA4/SCARB1/RAP1A/WNT3/WNT9A/CACNA1G/ADCY9/NCEH1/RAP1B/PRKACB/WNT10B/CAMK2G/KCNK3/CACNA1H/LEF1/FZD3/WNT9B/WNT16/ADCY2/WNT3A	-0.186963297044018
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1503	52/9376	0.959721582476074	SCARB1/ADCY9/PRKACB/HSD17B7/HSD17B1/IGF1/ADCY2/CYP2J2	-0.127252974207122
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1503	78/9376	0.959721582476074	DHX36/NUDT16/PARN/LSM5/EXOSC8/LSM4/C1D/EXOSC9/LSM3/DCP1B/EDC3/PNLDC1	-0.156070180503433
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1503	78/9376	0.959721582476074	HLA-DMA/C3/MAPK14/HLA-DPA1/STAT1/CYBA/IRAK4/IL1B/FCGR3A/TLR2/IL10/NCF1	-0.156070180503433
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	35/1503	226/9376	0.966091415988083	CALM2/PDE4B/PPP1CB/VIPR2/RAC2/RAP1A/PLD1/ATP2B4/F2R/ROCK2/MYL9/AFDN/ADCY9/FXYD1/RAP1B/PDE3A/ATP2B3/PRKACB/PIK3CB/NPR1/CALM3/ATP1B3/CAMK2G/GRIN2D/RYR2/PAK1/PTGER3/GRIA4/CALML4/ADCY2/RAPGEF3/ARAP3/OXTR/EDN1/CNGA1	-0.22544900855454
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1503	46/9376	0.949289826144812	HMOX2/FTH1/MMAB/ALAD/HCCS/COX10/PPOX	-0.150635799296431
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1503	105/9376	0.950581376928682	CALM2/FCER1G/MAPK14/MRAS/IRF9/STAT1/PIK3CB/CALM3/IL1B/PLK3/PAK1/EGR2/CALML4/IL10/PRKCD/IL23A	-0.222493333282244
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	10/1503	66/9376	0.945180346377951	CYP3A5/DHRS9/HSD11B1/COMT/CYP7B1/HSD17B6/SRD5A3/HSD17B7/HSD17B1/AKR1C2	-0.19526680359763
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	13/1503	86/9376	0.942982252549165	KCNMB4/KCNMA1/VAMP2/ADCY9/PRKACB/KCNMB1/ATP1B3/CAMK2G/RYR2/TRPM4/ABCC8/KCNMB2/ADCY2	-0.232084655402598
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/1503	112/9376	0.946868168425055	HLA-DMA/LAMA4/HSPA1B/LAMC3/MAPK14/HLA-DPA1/ITGA6/IL10RB/STAT1/PPIF/HSPA1A/IRAK4/LAMB3/LY96/TLR2/CIITA/IL10	-0.247149381636589
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1503	13/9376	0.959721582476074	XRCC4/LIG4	-0.0634938361161358
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1503	93/9376	0.939082408659384	CALM2/MAPK14/MAPK7/PLD1/MMP14/MAP3K2/MAP3K4/ADCY9/PRKACB/CALM3/CAMK2G/CALML4/ADCY2/PRKCD	-0.257949698730635
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1503	47/9376	0.92909217026939	ACAT2/HAGH/ACACB/ACSS1/MDH2/DLAT/ADH1C	-0.212922020333001
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1503	80/9376	0.935728542914172	PDGFRA/PDGFD/ERBB3/NRG2/VEGFA/PDGFC/PIK3CB/RPS6KB2/KDR/EIF4EBP1/IGF1/SHC4	-0.252237750459422
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	38/1503	248/9376	0.955851737385444	KPNA1/ABI1/MYL12A/VPS41/DYNLRB1/DYNLT3/ARHGEF26/RHOH/MAPK14/DCTN6/TUBA3E/ARPC1B/SKP1/ROCK2/DCTN4/MYL9/PODXL/DYNLT1/KLC1/IRAK4/RHOB/PIK3CB/IL18/IL1B/DYNC1LI1/DYNC2H1/PAK1/TNFSF10/LEF1/ACTR3B/LY96/TUBA3D/KIF5C/TLR2/KIF5A/PFN4/MLKL/WASF3	-0.307855307088779
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1503	216/9376	0.953056849264434	APOA1/CCL3/MMP9/CALM2/CCL2/HSPA1B/HSPA2/RAP1A/MAPK14/ROCK2/MAP3K5/IRF7/CYBA/RAP1B/HSPA1A/IRAK4/PIK3CB/CALM3/IL18/IL1B/FAS/CAMK2G/TNFSF10/SELE/OLR1/LY96/CALML4/CD36/TLR2/CYP2A6/NOS3/NCF1/CYP2J2	-0.304962456167292
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/1503	133/9376	0.938073727232252	TGFBR1/DEPP1/HOMER2/SGK1/KLF2/MAPK14/GABARAPL2/PRKAG1/SETD7/CSNK1E/PIK3CB/GABARAP/G6PC3/PLK3/IGF1/TNFSF10/HOMER1/PRKAA2/GADD45G/IL10	-0.314260131662172
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1503	107/9376	0.932813500724408	CALM2/SIK2/ACACB/PRKAG1/PYGL/PRKACB/PHKG1/G6PC3/PHKA1/CALM3/PPP4C/CAMK2G/PRKAA2/CALML4/ADCY2/PPARGC1A	-0.305388348577126
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1503	41/9376	0.912905895526021	BABAM2/NBN/UIMC1/RAD51C/POLD4/BLM	-0.244184744592611
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	36/1503	238/9376	0.943591807980677	RASGRP2/CALM2/ETS2/PDGFRA/PDGFD/RGL1/RAC2/RAP1A/IGF2/PLD1/GNB5/MRAS/RALGAPB/AFDN/RALBP1/NTRK1/VEGFA/EPHA2/PLA2G2A/PDGFC/RAP1B/PRKACB/GNGT1/PIK3CB/KDR/CALM3/TEK/ANGPT1/PAK1/NGF/IGF1/GNG7/CALML4/RIN1/SHC4/FGF18	-0.385123557357907
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1503	21/9376	0.89117004087064	ENPP1/ENPP3/PANK1	-0.218137946411952
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	35/1503	232/9376	0.941106293160805	RGCC/ITGA1/ITGA3/PDGFRA/PDGFD/PPP1CB/MYLK/MYLK3/MYL12A/ACTN1/LPAR1/RAC2/CFL2/MYH10/ARPC1B/F2R/ROCK2/MRAS/ITGA6/MYL9/PDGFC/PIK3CB/BCAR1/WASF1/PAK1/ITGB5/C7/ACTR3B/SCIN/INSRR/PIP4K2C/LPAR5/PFN4/ITGB3/FGF18	-0.396862237604629
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/1503	102/9376	0.917380924425658	CPA1/BST1/CPB1/KCNMA1/RAP1A/ATP2B4/SLC4A2/ADCY9/PLA2G2A/RAP1B/ATP2B3/ATP1B3/RYR2/ADCY2/PRSS3	-0.366557301096863
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1503	42/9376	0.89117004087064	MAOB/MAOA/ACAT2/DHTKD1/INMT/KMO	-0.308840477872188
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1503	122/9376	0.920388730735251	CAB39L/RHEB/ACACB/ADIPOR1/CAB39/PRKAG1/LEPR/RAB11B/PIK3CB/RPS6KB2/G6PC3/PPP2R1B/EIF4EBP1/IGF1/PRKAA2/PPP2R2B/CD36/PPARGC1A	-0.386709390826132
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/1503	168/9376	0.928302125906916	PRL/PRLR/STAT4/PDGFRA/IL13RA1/GHR/CSF3R/LEPR/IL10RB/IRF9/STAT1/CISH/CLCF1/CCND3/PIK3CB/CSF2RB/OSM/IL2RA/IL7/PIAS3/CTF1/IL11RA/IL10/IL13RA2/IL23A	-0.409706889487409
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1503	76/9376	0.902895962461043	CALM2/MYLK/MYLK3/SLC4A2/ADCY9/PRKACB/CALM3/ATP1B3/CAMK2G/CALML4/ADCY2	-0.371362128800721
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/1503	116/9376	0.914217541927639	PGD/H6PD/ACAT2/MCEE/SDHC/HIBCH/ACSS1/MDH2/DLAT/ALDOC/ADPGK/GOT2/ACADS/RGN/ENO4/CPS1/GLUD2	-0.406178555444304
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/1503	227/9376	0.934354492190362	CCL3/B2M/CCL4/CALM2/CCL2/PDGFRA/RHEB/RAC2/MAPK14/GNB5/ROCK2/IL10RB/ADCY9/VEGFA/HLA-E/PRKACB/GNGT1/PIK3CB/RPS6KB2/CALM3/IL1B/BCAR1/FAS/PTGER4/TAPBPL/EIF4EBP1/PTGER3/GNG7/CALML4/HLA-A/ADCY2/CCR1/ITGB3/AKAP13	-0.437447692283429
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1503	90/9376	0.901071930213647	RHEB/ADIPOR1/SESN1/PRKAG1/ADCY9/PRKACB/PIK3CB/RPS6KB2/EIF4EBP1/IGF1/PRKAA2/ADCY2/PPARGC1A	-0.412022993731624
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/1503	110/9376	0.907373132522833	SERPINE1/LTBR/ELOB/RBX1/VEGFA/PIK3CB/ALDOC/RPS6KB2/TEK/CAMK2G/ANGPT1/EIF4EBP1/IGF1/PDK1/NOS3/EDN1	-0.426955069364422
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	16/1503	110/9376	0.907373132522833	SPDYE2/CPEB4/MAPK14/RPS6KA2/ANAPC10/ADCY9/PRKACB/SPDYA/ANAPC15/PIK3CB/KIF22/IGF1/SPDYE5/ADCY2/MAD2L1/RPS6KA6	-0.426955069364422
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1503	29/9376	0.860440039461307	TEAD1/CSNK1E/PAK1/WWC1	-0.328865804884986
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1503	36/9376	0.866415317513122	RNASEH2C/POLE4/POLD4/RFC3/MCM2	-0.350856460298083
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	22/1503	150/9376	0.914934575293857	WNT5A/WNT4/TGFBR1/WNT6/WNT3/CTNNA3/WNT9A/SMAD2/PIK3CB/RPS6KB2/WNT10B/LRP5/LEF1/FZD3/WNT9B/WNT16/GADD45G/RARB/WNT3A/SHC4/CDH1/FGF18	-0.458867164648859
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1503	50/9376	0.873346640053227	HLA-DMA/LTBR/HLA-DPA1/TNFSF13B/CCL28/CD86/IL10	-0.392327738552141
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1503	170/9376	0.917380924425658	WNT5A/WNT4/TGFBR1/WNT6/SMARCB1/MGST2/IGF2/WNT3/WNT9A/SMAD2/MGST1/GSTA1/PIK3CB/RPS6KB2/SMARCD1/WNT10B/LRP5/TXNRD3/LEF1/FZD3/WNT9B/WNT16/GADD45G/WNT3A/SHC4	-0.474967954743688
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1503	65/9376	0.863749424228466	KCNA4/SCARB1/CACNA1G/ADCY9/NCEH1/PRKACB/KCNK3/CACNA1H/ADCY2	-0.481605972403443
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1503	23/9376	0.81367699383841	ACAT2/PDSS1/RCE1	-0.390885838144542
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1503	23/9376	0.81367699383841	ATP1B3/AQP1/GLUD2	-0.390885838144542
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/1503	133/9376	0.89117004087064	TYROBP/KLRC1/FCER1G/KLRC3/KLRD1/HCST/KLRC2/LCP2/RAC2/HLA-E/PIK3CB/FAS/PAK1/TNFSF10/ULBP2/ICAM2/FCGR3A/HLA-A/SHC4	-0.552284446587813
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/1503	133/9376	0.89117004087064	MAOB/MAOA/CALM2/PPP1CB/COMT/MAPK14/GNB5/PRKACB/GNGT1/PPP2R1B/CALM3/TH/CAMK2G/GNG7/GRIA4/CALML4/PPP2R2B/KIF5C/KIF5A	-0.552284446587813
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1503	93/9376	0.872005093755142	ITGA3/COL4A6/LAMA4/LAMC3/FHIT/ITGA6/COL4A5/PIK3CB/COL4A4/LAMB3/GADD45G/COL4A3/RARB	-0.541982156193752
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1503	187/9376	0.900701271254283	CAMP/CCL2/CTSB/MAPK14/GABARAPL2/ANTXR2/ANTXR1/GPSM3/IRF7/IRF9/STAT1/CYBA/IRAK4/ERBIN/MCU/GABARAP/OAS3/GBP1/IL18/IL1B/TXNIP/DHX33/OAS2/RNF31/OAS1/TNFAIP3/PRKCD	-0.599273907482028
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/1503	154/9376	0.89117004087064	CALM2/PPP1CB/MYLK/MYLK3/MAPK7/ROCK2/RGS2/MYL9/PRKAG1/ADCY9/CACNA2D3/PRKACB/NPR1/CALM3/CAMK2G/RYR2/PRKAA2/CALML4/ADCY2/OXTR/GUCY1A1/NOS3	-0.594964797356854
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1503	53/9376	0.823911924578516	ATP2B4/ESR1/CLTB/ADCY9/ATP2B3/PRKACB/ATP1B3	-0.561674933118242
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/1503	67/9376	0.837965859326124	ACSS1/GALM/DLAT/ALDOC/G6PC3/ADPGK/ENO4/BPGM/ADH1C	-0.581550480933335
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/1503	142/9376	0.878618350154152	TGFBR1/TYROBP/FOSL2/LCP2/LILRB3/FHL2/MAPK14/ACP5/MITF/IRF9/STAT1/CYBA/PIK3CB/IL1B/CTSK/TREM2/FCGR3A/SPI1/ITGB3/NCF1	-0.636791526896601
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/1503	169/9376	0.885896845362529	CTSD/DEPTOR/ATG9B/RHEB/VPS41/CTSB/GABARAPL2/VAMP8/MRAS/STX7/RAB1A/PRKACB/MTMR3/PIK3CB/GABARAP/RPS6KB2/CTSL/ATG2B/UVRAG/ATG4A/ATG4D/PRKAA2/RRAGD/PRKCD	-0.653998775422563
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1503	32/9376	0.77977378576181	GALM/GAA/AKR1B1/G6PC3	-0.545221019148167
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1503	109/9376	0.858466553132268	CCL3/CCL4/MAPK14/IRF7/IRF9/STAT1/IRAK4/PIK3CB/TOLLIP/IL1B/CTSK/CD86/LY96/TLR2/TLR7	-0.649378272823372
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1503	17/9376	0.733904739540527	GGT5/CDO1	-0.479779711580661
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1503	54/9376	0.80865429634558	ATRIP/RAD51C/FANCB/CENPX/FANCC/FANCM/BLM	-0.616106866045462
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1503	54/9376	0.80865429634558	HLA-DMA/HLA-DPA1/HLA-E/FAS/CD86/HLA-A/IL10	-0.616106866045462
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1503	89/9376	0.841104308237458	GLUL/GABARAPL2/GNB5/ADCY9/PRKACB/GNGT1/GABARAP/PLCL1/SLC38A2/GNG7/ADCY2/HAP1	-0.658058351820397
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	11/1503	83/9376	0.826748110205292	PEX11A/SLC25A17/PEX3/NUDT12/PEX11B/PEX7/ABCD3/DECR2/NUDT7/MPV17L/PEX12	-0.69268225305323
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/1503	139/9376	0.852702269322267	CTSD/KRT23/MMP9/CALM2/HSPA1B/KRT18/ESR1/FKBP5/ADCY9/HSPA1A/PRKACB/PIK3CB/CALM3/CALML4/ADCY2/KRT17/NOS3/SHC4/PRKCD	-0.764421664802643
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/1503	77/9376	0.810154582609672	TGFBR1/RAC2/PLD1/SMAD2/RALBP1/VEGFA/STAT1/PIK3CB/RPS6KB2/GADD45G	-0.730840085639607
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1503	91/9376	0.822618499265206	GRK3/PDE4B/GRK5/GNB5/ADCY9/PDE3A/PRKACB/GNGT1/PDE1A/GNG7/PDE7B/ADCY2	-0.74290463822673
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1503	70/9376	0.802053036783576	ACACB/ADIPOR1/PRKAG1/LEPR/G6PC3/NFKBIE/PRKAA2/CD36/PPARGC1A	-0.726292136525718
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1503	105/9376	0.831758704812597	CCL4/CCL21/LTBR/IRAK4/IL1B/TNFSF13B/CSNK2B/LY96/CCL13/TNFSF14/GADD45G/BCL2A1/TNFAIP3/EDARADD	-0.757458711626727
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1503	56/9376	0.77977378576181	HSPA1B/C3/RAB1A/HSPA1A/IL18/IL1B/TLR2	-0.722187676480144
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1503	154/9376	0.850662311740156	CALM2/PPP1CB/MAPK14/ATP2B4/CREM/ADCY9/TPM1/CACNA2D3/ATP2B3/PRKACB/PPP2R1B/CALM3/ATP1B3/CAMK2G/RYR2/CALML4/PPP2R2B/ADCY2/RAPGEF3/ADRA1B/SCN1B	-0.816417355515563
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1503	71/9376	0.790756515138737	PRL/PRLR/MAPK14/ESR1/STAT1/CISH/PIK3CB/TH/SHC4	-0.773246446411542
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1503	42/9376	0.742641700725533	SAT1/SLC40A1/GPX4/FTH1/STEAP3	-0.730338050001685
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1503	86/9376	0.797908059849294	NCK1/ERBB3/AREG/NRG2/CBL/PIK3CB/RPS6KB2/CAMK2G/PAK1/EIF4EBP1/SHC4	-0.822593672785164
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1503	73/9376	0.769091953080141	PDGFRA/PDGFD/MITF/PDGFC/PIK3CB/IGF1/GADD45G/CDH1/FGF18	-0.865334442889008
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1503	36/9376	0.693132254010498	CRPPA/UGDH/AKR1B1/DCXR	-0.805979616323931
NA	NA	hsa04081	Hormone signaling	30/1503	219/9376	0.85454661453349	PRL/PRLR/SMAD9/SLC40A1/VIPR2/IGF2/ESR1/GNB5/ADIPOR1/GHR/RAMP3/NPR3/AVPR1A/LEPR/ADCY9/PRKACB/GNGT1/RAMP1/PIK3CB/NPR1/PRKG2/PENK/IGF1/GNG7/GNA15/ADCY2/RAPGEF3/OXTR/ADRA1B/ITGB3	-0.951621591201161
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/1503	144/9376	0.823094551637466	C1QB/C3/MAPK14/C1QA/ACACB/ADIPOR1/MAP3K5/PRKAG1/IRAK4/ACADM/IL1B/FAS/LEF1/C1QC/LY96/PRKAA2/LPIN3/ADH1C/PPARGC1A	-0.934694225189242
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/1503	60/9376	0.727788866711022	RAC2/MAPK14/VEGFA/PIK3CB/KDR/SPHK1/NOS3	-0.924191078178899
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1503	75/9376	0.748582834331337	ARG1/GLUL/PYCR2/MTR/ALDOC/GOT2/ENO4/CPS1/ASNS	-0.955115159887647
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1503	68/9376	0.733904739540527	CYP3A5/DHRS3/DHRS9/HSD17B6/ALDH1A2/CYP26B1/CYP2A6/ADH1C	-0.96218462081323
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1503	83/9376	0.75158919109572	SCMH1/SKP1/RBBP4/UBE2D1/CSNK2B/E2F6/L3MBTL1/BCORL1/UBE2D4/SCML2	-0.993176807470806
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/1503	83/9376	0.75158919109572	CCL4/POLR2K/POLR3GL/POLR2L/IRF7/IL18/IL1B/ZDHHC1/POLR3K/MLKL	-0.993176807470806
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1503	38/9376	0.656651609062577	SGK1/PIK3CB/ATP1B3/IGF1	-0.926605519320394
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/1503	76/9376	0.738733060195399	CALM2/PDGFRA/PIK3CB/CALM3/CAMK2G/IGF1/CALML4/GADD45G/SHC4	-0.999182417231223
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1503	30/9376	0.623819028609448	SDHC/MDH2/DLAT	-0.901653276818291
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/1503	224/9376	0.835471913316225	TGFBR1/B2M/ETS2/HLA-DMA/IL1R2/CDKN2C/TLN2/LTBR/HLA-DPA1/SLC25A4/KAT2B/ANAPC10/SMAD2/ADCY9/TSPO/HLA-E/PRKACB/ANAPC15/CCND3/PIK3CB/CRTC3/IL2RA/POLB/ZFP36/EGR2/HLA-A/ADCY2/SPI1/PTTG1/MAD2L1	-1.0889327348071
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/1503	148/9376	0.800848752944561	WNT5A/WNT4/WNT6/WNT3/ESR1/WNT9A/PIK3CB/RPS6KB2/WNT10B/LRP5/IGF1/LEF1/FZD3/WNT9B/WNT16/GADD45G/WNT3A/SHC4/FGF18	-1.06697709830216
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1503	22/9376	0.567108207826771	MAOB/MAOA	-0.888151414613848
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/1503	99/9376	0.756144277102361	MMP9/CDKN2C/MAPK14/ESR1/ADCY9/NCOR1/PRKACB/PIK3CB/RPS6KB2/IGF1/ADCY2/SHC4	-1.0657167066027
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1503	39/9376	0.639814388317382	MTHFS/MTR/MTHFD2L/BHMT2	-0.984804415108367
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	27/1503	205/9376	0.821615305973419	ISG15/B2M/HLA-DMA/MAPK14/ENTPD3/HLA-DPA1/IRF7/IRF9/STAT1/HLA-E/IRAK4/PSMD3/EIF2AK2/CCND3/PIK3CB/OAS3/NEDD4/SAP30/FAS/TAPBPL/NFKBIE/OAS2/OAS1/TLR2/GADD45G/HLA-A/TNFAIP3	-1.12829113103158
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1503	70/9376	0.712936032696512	CYP3A5/MGST2/HSD11B1/MGST1/GSTA1/SULT1A1/CYP2A6/AKR1C2	-1.05327355744501
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/1503	70/9376	0.712936032696512	RAP1A/ELOB/RBX1/VEGFA/RAP1B/PIK3CB/PAK1/ARNT2	-1.05327355744501
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1503	31/9376	0.603695834138175	HSD17B14/UGDH/RGN	-0.965639081759783
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1503	31/9376	0.603695834138175	SMOX/HIBCH/ACADS	-0.965639081759783
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1503	63/9376	0.693132254010498	GGT5/GPX4/PLA2G2A/ALOX15B/LTA4H/PRXL2B/CYP2J2	-1.06775525960307
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/1503	115/9376	0.75943186091585	SGK1/PDE4B/PLD1/MMP14/MEF2A/WNK3/OXSR1/ADCY9/PRKACB/BGLAP/LRP5/WNK2/ADCY2/AKAP13	-1.13410454150294
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1503	23/9376	0.542451329225607	POLD4/RFC3	-0.959888418247511
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/1503	138/9376	0.768472716402943	WIPF1/CCL2/LCP2/RAC2/MAPK14/ARPC1B/SKAP2/RPS6KA2/ROCK2/IRAK4/PIK3CB/IL18/IL1B/BCAR1/ACTR3B/IL10/RPS6KA6	-1.19714772193279
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1503	41/9376	0.608603930350681	MAOB/MAOA/BPGM/GAMT	-1.09735268396296
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/1503	41/9376	0.608603930350681	MMP9/VEGFA/THBS1/CDH1	-1.09735268396296
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1503	73/9376	0.683637291626792	MAOB/MAOA/CYP3A5/MGST2/MGST1/GSTA1/CYP2A6/ADH1C	-1.18557820592541
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1503	103/9376	0.726779450807124	PPP1CB/RBM8A/PELO/PPP2R1B/ALYREF/NXT1/NUDT21/UPF3B/MAGOHB/GSPT2/PPP2R2B/NXT2	-1.21819509133253
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1503	33/9376	0.567108207826771	DLAT/GOT2/DHTKD1	-1.08839903927042
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/1503	119/9376	0.733904739540527	MMP9/CCL2/MAPK14/MMP14/MAP3K5/DAB2IP/PIK3CB/IL1B/FAS/SELE/IL18R1/TNFAIP3/EDN1/MLKL	-1.27635208104117
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1503	15/9376	0.415879352406298	AK1	-0.989195353499822
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1503	90/9376	0.693132254010498	SCARB1/SLC4A2/ADCY9/NCEH1/ABCC3/PRKACB/ATP1B3/AQP1/SLC27A5/ADCY2	-1.27806564562843
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1503	43/9376	0.580296770799486	ACAT2/ACADM/ACADS/ADH1C	-1.20520495445443
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1503	68/9376	0.642166647097961	PIK3CB/RPS6KB2/EIF4EBP1/LEF1/PIM2/BCL2A1/SPI1	-1.2939041017937
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1503	35/9376	0.534702024522384	HSD17B14/AKR1B1/ALDOC	-1.20493467320646
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1503	69/9376	0.632859884096541	FCER1G/LCP2/RAC2/MAPK14/MS4A2/PIK3CB/ALOX5AP	-1.33735446455835
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/1503	253/9376	0.789020115237246	TLN2/MYL12A/ACTN1/C3/MAPK14/ARPC1B/SKP1/ROCK2/RBX1/UBE2V2/MYL9/UBE2N/PLCD1/FNBP1L/UBE2D1/PIK3CB/BTRC/RPS6KB2/HCLS1/IL18/IL1B/BCAR1/TIFA/PLCD3/WASF1/ACTR3B/RNF31/PLCD4/UBE2D4/RRAGD/PFN4/PRKCD	-1.48637186700795
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1503	38/9376	0.492488706796932	UNG/RFXAP/CIITA	-1.36963730663034
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1503	47/9376	0.530909811582509	CACNA1G/PIK3CB/ABCC8/PRKCD	-1.40858394645132
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/1503	73/9376	0.598182630173443	FHIT/PIK3CB/RET/KIF5C/GADD45G/KIF5A/RARB	-1.50582196896182
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/1503	105/9376	0.653524696638469	CITED2/ATG9B/CCZ1B/GABARAPL2/MTX2/AMFR/MRAS/MITF/FUNDC1/GABARAP/CSNK2B	-1.55990677914345
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/1503	106/9376	0.647359369311691	MMP9/PDGFRA/IL1R2/PDGFD/KLK3/PDGFC/PIK3CB/IGF1/LEF1/INSRR/SLC46A1	-1.59529284696517
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1503	30/9376	0.415879352406298	PLA2G2A/CYP2J2	-1.40005565409976
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/1503	75/9376	0.582231093368818	MGST2/MAP3K5/MGST1/GSTA1/PIK3CB/FAS/ATP7B	-1.58707308226911
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1503	115/9376	0.650941595070728	MAOB/MAOA/KCND2/GNB5/HTR2B/HTR2A/PRKACB/ALOX15B/GNGT1/GNG7/RAPGEF3/CYP2J2	-1.64555756962307
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/1503	59/9376	0.52866019373682	CTNNA3/PIK3CB/LEF1/GADD45G/CDH1	-1.58678132223111
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/1503	214/9376	0.728760547440944	BST2/B2M/CALM2/RAC2/CFL2/MAPK14/GNB5/SKP1/ELOB/RBX1/HLA-E/IRAK4/GNGT1/PIK3CB/BTRC/RPS6KB2/CALM3/FAS/WEE1/TAPBPL/PAK1/GNG7/CALML4/TLR2/HLA-A	-1.75371737546444
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/1503	87/9376	0.573626692974205	TGFBR1/RAC2/AREG/SMAD2/PIK3CB/RPS6KB2/LEF1/GADD45G	-1.74566198974225
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1503	79/9376	0.552751038008371	CYP3A5/MGST2/HSD11B1/MGST1/GSTA1/CYP2A6/ADH1C	-1.74416061018903
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/1503	205/9376	0.699894519903283	HDAC9/ACTN1/C3/LTBR/MRPS18B/KAT2B/HDAC4/IRF7/IRF9/HLA-E/PRKACB/EIF2AK2/YWHAH/CCND3/PIK3CB/GTF2A2/GTF2H2/POLB/EGR2/SCIN/HLA-A/GTF2H2C/HPN	-1.89818052167998
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1503	72/9376	0.519849190507873	ISG15/PIN1/MAPK14/IFIH1/IRF7/DHX58	-1.78691570374891
NA	NA	hsa04082	Neuroactive ligand signaling	22/1503	199/9376	0.689649177357178	SLC1A1/GRM7/SLC1A2/GNB5/HTR2B/ADCY9/HTR2A/PRKACB/GNGT1/GRIK2/GRIK1/GRIN2D/PENK/GLRB/P2RY14/GNG7/GRIA4/TACR1/SLC1A3/P2RY13/ADCY2/ADRA1B	-1.93341051419757
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/1503	201/9376	0.682786996487953	IGFBP3/MMP9/IL1R2/CDKN2C/NR4A3/MITF/NUPR1/NTRK1/HOXA9/NCOR1/MEIS1/SUPT3H/IGF1/LDB1/SLC45A3/CD86/WNT16/GADD45G/BCL2A1/SPI1/TSPAN7/ARNT2	-1.9862823205623
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1503	91/9376	0.548412332843471	CD81/LILRB3/RAC2/CD79B/PIK3CB/PIK3AP1/NFKBIE/DAPP1	-1.89132785046263
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1503	109/9376	0.572311035421512	TGFBR1/HLA-DMA/MAPK14/HLA-DPA1/SMAD2/STAT1/IL1B/IL2RA/NFKBIE/IL23A	-1.96230592322919
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/1503	196/9376	0.66837753065298	CALM2/C3/MAPK14/GNB5/VEGFA/IRF7/IRF9/STAT1/HLA-E/GNGT1/EIF2AK2/PIK3CB/CALM3/FAS/ZFP36/LEF1/GNG7/CD86/CALML4/HLA-A/CCR1	-2.04996122613312
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/1503	93/9376	0.536618519233934	MAML3/STAT4/HLA-DMA/MAPK14/HLA-DPA1/STAT1/IL2RA/NFKBIE	-1.96214444350933
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1503	48/9376	0.389886892880905	PIK3CB/G6PC3/ATP1B3	-1.85153406975446
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1503	26/9376	0.239930395619018	PLA2G2A	-1.69562275661892
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/1503	144/9376	0.606490722259185	PUM2/SLC25A4/MAP3K5/DAB1/PPIF/PSMD3/MCU/PIK3CB/ATG2B/PSMA2/GRIN2D/NFYA/ATXN2L/RELN	-2.07913805293871
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1503	168/9376	0.631245445616703	STAT4/GLUL/CHMP5/SLC25A4/FTH1/IRF9/STAT1/PYGL/EIF2AK2/IL1B/FAS/CAMK2G/TNFSF10/RNF31/TNFAIP3/GLUD2/MLKL	-2.10719332158372
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/1503	60/9376	0.415879352406298	PPP2R1B/PRKG2/IGF1/GUCY1A1	-1.98316315928596
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/1503	122/9376	0.562459779893764	IGFBP3/MAPK14/GHR/ADCY9/STAT1/PRKACB/PIK3CB/BCAR1/IGF1/ADCY2/SHC4	-2.12533870571178
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/1503	195/9376	0.639814388317382	CAMP/HDAC9/RAC2/C3/MAPK14/SLC25A4/HAT1/SELPLG/HDAC4/CYBA/PPIF/PIK3CB/CLCN5/FGG/FCGR3A/TLR2/SIGLEC9/TLR7/ITGB3/NCF1	-2.22071934020708
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/1503	71/9376	0.439309175077076	PDGFRA/NTRK1/PIK3CB/PDK1/RET	-2.07199850544771
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1503	41/9376	0.30430196517534	GRIN2D/GRIA4	-1.9505206233333
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/1503	90/9376	0.485192577807348	MAPK14/STAT1/PIK3CB/RPS6KB2/CSNK2B/NFKBIE/TLR2	-2.14410829752525
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/1503	75/9376	0.415879352406298	GPX8/ADCY9/PRKACB/ATP1B3/ADCY2	-2.21903100465058
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/1503	94/9376	0.464546085134695	MMP9/CCL2/MAPK14/MAPK7/USP25/IL1B/TNFAIP3	-2.27960838473258
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/1503	32/9376	0.194943446440452	DIABLO	-1.99310402770176
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/1503	122/9376	0.511327072630695	NCK1/LCP2/ITK/MAPK14/PIK3CB/PPP2R1B/PAK1/NFKBIE/PPP2R2B/IL10	-2.37371432212401
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/1503	77/9376	0.405077291304836	TGFBR1/CBL/PIK3CB/GADD45G/SHC4	-2.29024945320525
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1503	46/9376	0.271225664612803	PSMD3/PSMA2	-2.16484180928408
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/1503	238/9376	0.629061205320452	ISG15/CCL2/MASP1/RPL36AL/MX1/C1QB/C3/MAPK14/C1QA/IFIH1/IRF9/STAT1/IRAK4/EIF2AK2/PIK3CB/OAS3/IL1B/FGG/C7/OAS2/C1QC/OAS1/TLR2/TLR7	-2.53256243561407
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1503	143/9376	0.523484499532404	HLA-DMA/ACTN1/C1QB/C3/C1QA/HLA-DPA1/SNRPD3/C7/CD86/C1QC/FCGR3A/IL10	-2.5088149906111
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	41/1503	370/9376	0.691258923594253	PRL/CNR1/GAL/PRLR/GRM7/RXFP1/PGRMC2/VIPR2/LPAR1/ADM/C3/LYNX1/F2R/HTR2B/LYPD6/GHR/EDNRB/AVPR1A/LEPR/TSPO/HTR2A/TMEM97/GRIK2/GRIK1/NPW/PTGIR/PTGER4/GRIN2D/F2RL2/PENK/GLRB/PTGER3/P2RY14/GRIA4/CYSLTR1/TACR1/P2RY13/OXTR/PRSS3/ADRA1B/EDN1	-2.64742891243236
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1503	191/9376	0.555231596144535	MAOB/MAOA/CALM2/HDAC9/SLC29A1/PPP1CB/GNB5/HAT1/HDAC4/PRKACB/GNGT1/CALM3/TH/GRIN2D/GNG7/CALML4/SHC4	-2.71335134854127
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1503	115/9376	0.433961063380485	GNB5/ADCY9/PRKACB/GNGT1/PIK3CB/CAMK2G/GNG7/ADCY2	-2.66846362586334
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/1503	65/9376	0.287916474742822	CACNA1G/PIK3CB/CACNA1H	-2.51700718820452
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/1503	117/9376	0.426542925544922	SMARCB1/CECR2/RBBP4/MEAF6/TFPT/ACTR6/SMARCD1/INO80C	-2.72713606275807
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	13/1503	163/9376	0.497524378645572	TGFBR1/MMP9/STAT4/MAPK14/ATP6AP1/IFIH1/IRF7/STAT1/IRAK4/PIK3CB/FAS/EGR2/TLR2	-2.8275042429525
Genetic Information Processing	Translation	hsa03010	Ribosome	20/1503	222/9376	0.561999124873376	MRPL33/MRPS6/RPL36AL/MRPL52/MRPS18A/MRPL54/MRPL42/MRPS28/MRPS18B/MRPL47/MRPS33/MRPL53/MRPL32/MRPL27/MRPL13/MRPL48/MRPL50/MRPL34/MRPL35/MRPL46	-2.88563245690352
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/1503	217/9376	0.517453572118436	KPNA1/MGST2/ESR1/RPS6KA2/MGST1/ADCY9/VEGFA/PRKACB/PAQR7/GSTA1/CCND3/PIK3CB/RPS6KB2/EIF4EBP1/ADCY2/PAQR5/RPS6KA6/FGF18	-3.14224428647065
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1503	183/9376	0.477238601121982	MDN1/GNL2/AK6/RRP7A/TCOF1/NOP10/POP4/EFL1/SNU13/SBDS/NXT1/CSNK2B/FBLL1/NXT2	-3.12029337510272
Genetic Information Processing	Transcription	hsa03040	Spliceosome	21/1503	243/9376	0.539102864230387	HSPA1B/SNRPG/BCAS2/RBM8A/SNRPD3/LSM5/RP9/LSM4/CCDC12/HSPA1A/SNRNP27/SNU13/ALYREF/SNRPA/ZMAT2/SF3B6/LSM3/PPIL1/MAGOHB/SF3A2/THOC3	-3.18050014689825
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1503	86/9376	0.145074192699872	PRKACB/PDE1A	-3.47988425100671
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1503	323/9376	0.444205500248214	MMP9/PDGFRA/STMN1/FOXP1/ERBB3/MAPK7/WNT3/DICER1/ABCC1/HDAC4/VEGFA/TPM1/PIK3CB/TIMP3/THBS1/HOXD10/FZD3/SLC45A3/KIF23/WNT3A/ITGB3/SHC4/CDCA5	-4.44134232303919
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	13/1503	449/9376	0.180615754385809	CALM2/NCALD/GRK3/RGS2/PRKACB/PDE1A/CALM3/CAMK2G/PRKG2/GNG7/OR3A2/CALML4/ANO2	-7.77415177924482