ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0022853 active monoatomic ion transmembrane transporter activity 40/3038 118/18639 0.338983050847458 2.07975809241138 2.10838409906777e-06 0.00283999338144429 GO:0015399 primary active transmembrane transporter activity 48/3038 166/18639 0.289156626506024 1.77405871015332 3.05135063246983e-05 0.0205508465096843 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 24/3038 68/18639 0.352941176470588 2.1653951903342 0.000107469785745095 0.0482539337995478 GO:0016651 oxidoreductase activity, acting on NAD(P)H 28/3038 88/18639 0.318181818181818 1.95213657310431 0.000233411105871968 0.0527048039171613 GO:0050840 extracellular matrix binding 23/3038 67/18639 0.343283582089552 2.106143083136 0.000238326506486333 0.0527048039171613 GO:0022804 active transmembrane transporter activity 103/3038 457/18639 0.225382932166302 1.3827888323396 0.000276968540806688 0.0527048039171613 GO:0003954 NADH dehydrogenase activity 17/3038 44/18639 0.386363636363636 2.37045155305524 0.000311536205015778 0.0527048039171613 GO:0009055 electron transfer activity 34/3038 116/18639 0.293103448275862 1.79827359197294 0.000313020364764135 0.0527048039171613 GO:0008137 NADH dehydrogenase (ubiquinone) activity 16/3038 41/18639 0.390243902439024 2.39425809662968 0.000407198160029406 0.0609439912844011 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 20/3038 58/18639 0.344827586206897 2.1156159905564 0.00055615500421476 0.0693263956571846 GO:0008191 metalloendopeptidase inhibitor activity 8/3038 14/18639 0.571428571428571 3.50587792720775 0.000584803761551748 0.0693263956571846 GO:0051117 ATPase binding 26/3038 84/18639 0.30952380952381 1.89901721057086 0.000617607088259996 0.0693263956571846 GO:0016409 palmitoyltransferase activity 14/3038 36/18639 0.388888888888889 2.38594470046083 0.000964164967917665 0.0902960258542498 GO:0015078 proton transmembrane transporter activity 47/3038 185/18639 0.254054054054054 1.55869437574507 0.000969339342494336 0.0902960258542498 GO:0019199 transmembrane receptor protein kinase activity 24/3038 78/18639 0.307692307692308 1.88778042234263 0.00107845951927482 0.0902960258542498 GO:0070008 serine-type exopeptidase activity 7/3038 12/18639 0.583333333333333 3.57891705069124 0.00112164023377672 0.0902960258542498 GO:0016417 S-acyltransferase activity 12/3038 29/18639 0.413793103448276 2.53873918866768 0.00116256339695525 0.0902960258542498 GO:0001540 amyloid-beta binding 25/3038 83/18639 0.301204819277108 1.84797782307637 0.00120662840785189 0.0902960258542498 GO:0003779 actin binding 96/3038 443/18639 0.216704288939052 1.32954287081468 0.00167497907966513 0.118747201068891 GO:0005518 collagen binding 22/3038 72/18639 0.305555555555556 1.87467083607637 0.00188644571147605 0.127052118667912 GO:0004714 transmembrane receptor protein tyrosine kinase activity 19/3038 60/18639 0.316666666666667 1.94284068466096 0.00238020984432309 0.148221974494553 GO:0005201 extracellular matrix structural constituent 42/3038 168/18639 0.25 1.53382159315339 0.002420848878159 0.148221974494553 GO:0030215 semaphorin receptor binding 10/3038 24/18639 0.416666666666667 2.55636932192232 0.00280023539663337 0.163996394750658 GO:0045499 chemorepellent activity 11/3038 28/18639 0.392857142857143 2.41029107495533 0.00303411898904945 0.170289928260401 GO:0019706 protein-cysteine S-palmitoyltransferase activity 10/3038 25/18639 0.4 2.45411454904542 0.00399332131493188 0.20688476196974 GO:0019707 protein-cysteine S-acyltransferase activity 10/3038 25/18639 0.4 2.45411454904542 0.00399332131493188 0.20688476196974 GO:0030228 lipoprotein particle receptor activity 8/3038 18/18639 0.444444444444444 2.72679394338381 0.00461571621672897 0.230272953479034 GO:0016757 glycosyltransferase activity 60/3038 267/18639 0.224719101123595 1.37871603878956 0.0050484431130829 0.242866174047238 GO:0005109 frizzled binding 13/3038 38/18639 0.342105263157895 2.09891375905201 0.00538599882073953 0.250170359018488 GO:0004129 cytochrome-c oxidase activity 7/3038 15/18639 0.466666666666667 2.863133640553 0.00579727314564457 0.251393104662428 GO:0005041 low-density lipoprotein particle receptor activity 7/3038 15/18639 0.466666666666667 2.863133640553 0.00579727314564457 0.251393104662428 GO:0008238 exopeptidase activity 27/3038 102/18639 0.264705882352941 1.62404639275065 0.00597221926443778 0.251393104662428 GO:0016776 phosphotransferase activity, phosphate group as acceptor 13/3038 39/18639 0.333333333333333 2.04509545753785 0.00689519830577504 0.281449458117545 GO:0033218 amide binding 55/3038 247/18639 0.222672064777328 1.36615688459006 0.00848766913307048 0.336261480066057 GO:0016675 oxidoreductase activity, acting on a heme group of donors 7/3038 16/18639 0.4375 2.68418778801843 0.0088727960430375 0.339136522413444 GO:0071813 lipoprotein particle binding 11/3038 32/18639 0.34375 2.10900469058591 0.00974490450278959 0.339136522413444 GO:0071814 protein-lipid complex binding 11/3038 32/18639 0.34375 2.10900469058591 0.00974490450278959 0.339136522413444 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 16/3038 54/18639 0.296296296296296 1.81786262892254 0.0102350423240857 0.339136522413444 GO:0017080 sodium channel regulator activity 13/3038 41/18639 0.317073170731707 1.94533470351162 0.0109042277762956 0.339136522413444 GO:0042578 phosphoric ester hydrolase activity 76/3038 363/18639 0.209366391184573 1.28452276671799 0.0112213263584258 0.339136522413444 GO:0005006 epidermal growth factor receptor activity 15/3038 50/18639 0.3 1.84058591178407 0.0112577053300428 0.339136522413444 GO:0005017 platelet-derived growth factor receptor activity 15/3038 50/18639 0.3 1.84058591178407 0.0112577053300428 0.339136522413444 GO:0005019 platelet-derived growth factor beta-receptor activity 15/3038 50/18639 0.3 1.84058591178407 0.0112577053300428 0.339136522413444 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/3038 13/18639 0.461538461538462 2.83167063351395 0.0113297279202709 0.339136522413444 GO:0008035 high-density lipoprotein particle binding 6/3038 13/18639 0.461538461538462 2.83167063351395 0.0113297279202709 0.339136522413444 GO:0004659 prenyltransferase activity 7/3038 17/18639 0.411764705882353 2.52629438872323 0.0129927383093663 0.346028288614833 GO:0030169 low-density lipoprotein particle binding 7/3038 17/18639 0.411764705882353 2.52629438872323 0.0129927383093663 0.346028288614833 GO:0038191 neuropilin binding 7/3038 17/18639 0.411764705882353 2.52629438872323 0.0129927383093663 0.346028288614833 GO:0120020 cholesterol transfer activity 9/3038 25/18639 0.36 2.20870309414088 0.0135857183119817 0.346028288614833 GO:0005010 insulin-like growth factor receptor activity 15/3038 51/18639 0.294117647058824 1.80449599194517 0.0136021082479794 0.346028288614833 GO:0005021 vascular endothelial growth factor receptor activity 15/3038 51/18639 0.294117647058824 1.80449599194517 0.0136021082479794 0.346028288614833 GO:0005030 neurotrophin receptor activity 15/3038 51/18639 0.294117647058824 1.80449599194517 0.0136021082479794 0.346028288614833 GO:0008373 sialyltransferase activity 8/3038 21/18639 0.380952380952381 2.33725195147183 0.0136150700048895 0.346028288614833 GO:0016783 sulfurtransferase activity 5/3038 10/18639 0.5 3.06764318630678 0.0140481691918903 0.350423775953265 GO:0019955 cytokine binding 34/3038 144/18639 0.236111111111111 1.44860928242265 0.0144215180496257 0.353196087506288 GO:0005178 integrin binding 37/3038 161/18639 0.229813664596273 1.4099726446379 0.0168935813598109 0.36261829735777 GO:0001965 G-protein alpha-subunit binding 10/3038 30/18639 0.333333333333333 2.04509545753785 0.0169227497653003 0.36261829735777 GO:0001968 fibronectin binding 10/3038 30/18639 0.333333333333333 2.04509545753785 0.0169227497653003 0.36261829735777 GO:0032036 myosin heavy chain binding 6/3038 14/18639 0.428571428571429 2.62940844540581 0.0171320762672236 0.36261829735777 GO:0044548 S100 protein binding 6/3038 14/18639 0.428571428571429 2.62940844540581 0.0171320762672236 0.36261829735777 GO:0005160 transforming growth factor beta receptor binding 9/3038 26/18639 0.346153846153846 2.12375297513546 0.017837665185591 0.36261829735777 GO:0043548 phosphatidylinositol 3-kinase binding 9/3038 26/18639 0.346153846153846 2.12375297513546 0.017837665185591 0.36261829735777 GO:0015101 organic cation transmembrane transporter activity 21/3038 81/18639 0.259259259259259 1.59062980030722 0.0179016090840789 0.36261829735777 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 7/3038 18/18639 0.388888888888889 2.38594470046083 0.0183235705501355 0.36261829735777 GO:0005003 ephrin receptor activity 15/3038 53/18639 0.283018867924528 1.73640180356988 0.0194086641312103 0.36261829735777 GO:0005005 transmembrane-ephrin receptor activity 15/3038 53/18639 0.283018867924528 1.73640180356988 0.0194086641312103 0.36261829735777 GO:0019205 nucleobase-containing compound kinase activity 13/3038 44/18639 0.295454545454545 1.81269824645401 0.0200392995221585 0.36261829735777 GO:0008237 metallopeptidase activity 41/3038 184/18639 0.222826086956522 1.36710185476715 0.0204998055608415 0.36261829735777 GO:0005004 GPI-linked ephrin receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0005008 hepatocyte growth factor receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0005009 insulin receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0005011 macrophage colony-stimulating factor receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0005018 platelet-derived growth factor alpha-receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0005020 stem cell factor receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0008288 boss receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0036332 placental growth factor receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0038062 protein tyrosine kinase collagen receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0060175 brain-derived neurotrophic factor receptor activity 14/3038 49/18639 0.285714285714286 1.75293896360387 0.0216339210065961 0.36261829735777 GO:0032934 sterol binding 18/3038 68/18639 0.264705882352941 1.62404639275065 0.0220738701163728 0.36261829735777 GO:0019206 nucleoside kinase activity 5/3038 11/18639 0.454545454545455 2.78876653300616 0.0223439633858166 0.36261829735777 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/3038 11/18639 0.454545454545455 2.78876653300616 0.0223439633858166 0.36261829735777 GO:0048185 activin binding 5/3038 11/18639 0.454545454545455 2.78876653300616 0.0223439633858166 0.36261829735777 GO:0180030 inositol phosphate kinase activity 5/3038 11/18639 0.454545454545455 2.78876653300616 0.0223439633858166 0.36261829735777 GO:0042626 ATPase-coupled transmembrane transporter activity 24/3038 98/18639 0.244897959183673 1.50251911166046 0.0236307207761369 0.378935486731624 GO:0008009 chemokine activity 13/3038 45/18639 0.288888888888889 1.77241606319947 0.0240915420854943 0.381780084578363 GO:0005007 fibroblast growth factor receptor activity 14/3038 50/18639 0.28 1.7178801843318 0.0256691159919224 0.397428726909419 GO:0048020 CCR chemokine receptor binding 14/3038 50/18639 0.28 1.7178801843318 0.0256691159919224 0.397428726909419 GO:0098632 cell-cell adhesion mediator activity 15/3038 55/18639 0.272727272727273 1.6732599198037 0.0269254297143884 0.412142657105467 GO:0004180 carboxypeptidase activity 13/3038 46/18639 0.282608695652174 1.73388527921688 0.0287183545813563 0.434647456416706 GO:0008514 organic anion transmembrane transporter activity 56/3038 269/18639 0.20817843866171 1.27723433779316 0.0291011021943484 0.435546496175414 GO:0019838 growth factor binding 31/3038 136/18639 0.227941176470588 1.3984843937575 0.0299127671711956 0.442774696479126 GO:0042625 ATPase-coupled ion transmembrane transporter activity 8/3038 24/18639 0.333333333333333 2.04509545753785 0.0313477983752318 0.449207280972737 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 8/3038 24/18639 0.333333333333333 2.04509545753785 0.0313477983752318 0.449207280972737 GO:0046961 proton-transporting ATPase activity, rotational mechanism 8/3038 24/18639 0.333333333333333 2.04509545753785 0.0313477983752318 0.449207280972737 GO:0015026 coreceptor activity 16/3038 61/18639 0.262295081967213 1.609255441997 0.0322843048342335 0.450131004425282 GO:0042277 peptide binding 52/3038 249/18639 0.208835341365462 1.28126462399962 0.0326491505181704 0.450131004425282 GO:0000149 SNARE binding 25/3038 106/18639 0.235849056603774 1.4470015029749 0.0327489520665758 0.450131004425282 GO:0008013 beta-catenin binding 25/3038 106/18639 0.235849056603774 1.4470015029749 0.0327489520665758 0.450131004425282 GO:0008179 adenylate cyclase binding 5/3038 12/18639 0.416666666666667 2.55636932192232 0.0332576571724133 0.452505699103441 GO:0098631 cell adhesion mediator activity 19/3038 76/18639 0.25 1.53382159315339 0.0335985602094381 0.452572606021132 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/3038 16/18639 0.375 2.30073238973009 0.0341781010647529 0.455820813210121 GO:0043236 laminin binding 9/3038 29/18639 0.310344827586207 1.90405439150076 0.0362693828004071 0.478969202275964 GO:0000030 mannosyltransferase activity 8/3038 25/18639 0.32 1.96329163923634 0.0397064242873494 0.519267509854948 GO:0005496 steroid binding 25/3038 108/18639 0.231481481481481 1.42020517884573 0.0402011030432915 0.52068159422417 GO:0038064 collagen receptor activity 14/3038 53/18639 0.264150943396226 1.62064168333188 0.0410942734753314 0.522207418596899 GO:1901505 carbohydrate derivative transmembrane transporter activity 14/3038 53/18639 0.264150943396226 1.62064168333188 0.0410942734753314 0.522207418596899 GO:0004550 nucleoside diphosphate kinase activity 6/3038 17/18639 0.352941176470588 2.1653951903342 0.045733753476782 0.541646121023729 GO:0008429 phosphatidylethanolamine binding 6/3038 17/18639 0.352941176470588 2.1653951903342 0.045733753476782 0.541646121023729 GO:0008484 sulfuric ester hydrolase activity 6/3038 17/18639 0.352941176470588 2.1653951903342 0.045733753476782 0.541646121023729 GO:0032977 membrane insertase activity 6/3038 17/18639 0.352941176470588 2.1653951903342 0.045733753476782 0.541646121023729 GO:0043177 organic acid binding 40/3038 189/18639 0.211640211640212 1.29847330637324 0.0460775395718858 0.541646121023729 GO:0016763 pentosyltransferase activity 13/3038 49/18639 0.26530612244898 1.62772903763217 0.0464320283709648 0.541646121023729 GO:0035254 glutamate receptor binding 13/3038 49/18639 0.26530612244898 1.62772903763217 0.0464320283709648 0.541646121023729 GO:0039706 co-receptor binding 5/3038 13/18639 0.384615384615385 2.35972552792829 0.0469626129550023 0.541646121023729 GO:0061459 L-arginine transmembrane transporter activity 5/3038 13/18639 0.384615384615385 2.35972552792829 0.0469626129550023 0.541646121023729 GO:0061135 endopeptidase regulator activity 39/3038 184/18639 0.21195652173913 1.30041395941266 0.0474126063411423 0.541646121023729 GO:0015485 cholesterol binding 14/3038 54/18639 0.259259259259259 1.59062980030722 0.0474493261178916 0.541646121023729 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 14/3038 54/18639 0.259259259259259 1.59062980030722 0.0474493261178916 0.541646121023729 GO:0017124 SH3 domain binding 26/3038 115/18639 0.226086956521739 1.3871082233735 0.0478582782820178 0.541723536519983 GO:0004222 metalloendopeptidase activity 25/3038 110/18639 0.227272727272727 1.39438326650308 0.0488391173800216 0.548219092590742 GO:0015036 disulfide oxidoreductase activity 11/3038 40/18639 0.275 1.68720375246873 0.0507138420424753 0.564558225051358 GO:0016791 phosphatase activity 55/3038 273/18639 0.201465201465201 1.2360467051053 0.0522126241574937 0.57647872737823 GO:0015605 organophosphate ester transmembrane transporter activity 13/3038 50/18639 0.26 1.59517445687953 0.0537271056933311 0.5868890744979 GO:0070325 lipoprotein particle receptor binding 9/3038 31/18639 0.290322580645161 1.78121217269426 0.0540269081200739 0.5868890744979 GO:0016782 transferase activity, transferring sulphur-containing groups 17/3038 70/18639 0.242857142857143 1.48999811906329 0.0546875638614287 0.589313188170756 GO:0030246 carbohydrate binding 56/3038 280/18639 0.2 1.22705727452271 0.0567263072811468 0.604667929858124 GO:0004896 cytokine receptor activity 22/3038 96/18639 0.229166666666667 1.40600312705727 0.057010265101694 0.604667929858124 GO:0031406 carboxylic acid binding 39/3038 187/18639 0.20855614973262 1.2795517033793 0.0585939973069113 0.611597525824959 GO:0099106 ion channel regulator activity 34/3038 160/18639 0.2125 1.30374835418038 0.0589110856762456 0.611597525824959 GO:0098641 cadherin binding involved in cell-cell adhesion 6/3038 18/18639 0.333333333333333 2.04509545753785 0.0594388449401052 0.611597525824959 GO:0001618 virus receptor activity 19/3038 81/18639 0.234567901234568 1.43914124789701 0.059948618137592 0.611597525824959 GO:0015252 proton channel activity 8/3038 27/18639 0.296296296296296 1.81786262892254 0.0605610225483394 0.611597525824959 GO:0060589 nucleoside-triphosphatase regulator activity 93/3038 490/18639 0.189795918367347 1.16445231153686 0.0607533987254753 0.611597525824959 GO:0008235 metalloexopeptidase activity 16/3038 66/18639 0.242424242424242 1.48734215093662 0.0618932976501217 0.611597525824959 GO:0004866 endopeptidase inhibitor activity 34/3038 161/18639 0.211180124223602 1.29565053831591 0.0634116863904205 0.611597525824959 GO:0005161 platelet-derived growth factor receptor binding 5/3038 14/18639 0.357142857142857 2.19117370450484 0.0635351333371014 0.611597525824959 GO:0008195 phosphatidate phosphatase activity 5/3038 14/18639 0.357142857142857 2.19117370450484 0.0635351333371014 0.611597525824959 GO:0042043 neurexin family protein binding 5/3038 14/18639 0.357142857142857 2.19117370450484 0.0635351333371014 0.611597525824959 GO:0005096 GTPase activator activity 54/3038 271/18639 0.199261992619926 1.22252938790086 0.063832692844403 0.611597525824959 GO:0120015 sterol transfer activity 9/3038 32/18639 0.28125 1.72554929229756 0.0647087301495487 0.611597525824959 GO:0005031 tumor necrosis factor receptor activity 4/3038 10/18639 0.4 2.45411454904542 0.0649850017689013 0.611597525824959 GO:0005528 FK506 binding 4/3038 10/18639 0.4 2.45411454904542 0.0649850017689013 0.611597525824959 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/3038 10/18639 0.4 2.45411454904542 0.0649850017689013 0.611597525824959 GO:0008081 phosphoric diester hydrolase activity 20/3038 87/18639 0.229885057471264 1.41041066037093 0.0653823635625791 0.611597525824959 GO:0140272 exogenous protein binding 19/3038 82/18639 0.231707317073171 1.42159074487387 0.0665755256534698 0.618463676242923 GO:0023023 MHC protein complex binding 10/3038 37/18639 0.27027027027027 1.65818550611177 0.0674647654272482 0.620444311952272 GO:0005283 amino acid:sodium symporter activity 7/3038 23/18639 0.304347826086957 1.86726106992587 0.0677099583199584 0.620444311952272 GO:0016500 protein-hormone receptor activity 16/3038 67/18639 0.238805970149254 1.46514301435548 0.0695045598385186 0.632585419611382 GO:0005125 cytokine activity 47/3038 234/18639 0.200854700854701 1.23230110902922 0.0710300878297954 0.642131062461305 GO:0051537 2 iron, 2 sulfur cluster binding 8/3038 28/18639 0.285714285714286 1.75293896360387 0.0731462186607696 0.648050178235389 GO:0030695 GTPase regulator activity 92/3038 489/18639 0.188139059304703 1.15428700670848 0.0735421691361147 0.648050178235389 GO:0003756 protein disulfide isomerase activity 6/3038 19/18639 0.315789473684211 1.93745885450955 0.075325276201714 0.648050178235389 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 6/3038 19/18639 0.315789473684211 1.93745885450955 0.075325276201714 0.648050178235389 GO:0015245 fatty acid transmembrane transporter activity 6/3038 19/18639 0.315789473684211 1.93745885450955 0.075325276201714 0.648050178235389 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 6/3038 19/18639 0.315789473684211 1.93745885450955 0.075325276201714 0.648050178235389 GO:0050145 nucleoside monophosphate kinase activity 6/3038 19/18639 0.315789473684211 1.93745885450955 0.075325276201714 0.648050178235389 GO:0030414 peptidase inhibitor activity 35/3038 169/18639 0.207100591715976 1.27062143811523 0.0759499206005993 0.648050178235389 GO:0019956 chemokine binding 9/3038 33/18639 0.272727272727273 1.6732599198037 0.076632660109611 0.648050178235389 GO:1901682 sulfur compound transmembrane transporter activity 15/3038 63/18639 0.238095238095238 1.4607824696699 0.0787747569574756 0.648050178235389 GO:0008375 acetylglucosaminyltransferase activity 11/3038 43/18639 0.255813953488372 1.56949186276161 0.0798707164574994 0.648050178235389 GO:0005543 phospholipid binding 93/3038 497/18639 0.187122736418511 1.14805157475465 0.0803396966623086 0.648050178235389 GO:0141108 transporter regulator activity 35/3038 170/18639 0.205882352941176 1.26314719436162 0.0812280035287358 0.648050178235389 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 7/3038 24/18639 0.291666666666667 1.78945852534562 0.0826826124148458 0.648050178235389 GO:0019957 C-C chemokine binding 7/3038 24/18639 0.291666666666667 1.78945852534562 0.0826826124148458 0.648050178235389 GO:0050431 transforming growth factor beta binding 7/3038 24/18639 0.291666666666667 1.78945852534562 0.0826826124148458 0.648050178235389 GO:0060229 lipase activator activity 7/3038 24/18639 0.291666666666667 1.78945852534562 0.0826826124148458 0.648050178235389 GO:0070840 dynein complex binding 7/3038 24/18639 0.291666666666667 1.78945852534562 0.0826826124148458 0.648050178235389 GO:0005523 tropomyosin binding 5/3038 15/18639 0.333333333333333 2.04509545753785 0.0829583941648475 0.648050178235389 GO:0031005 filamin binding 5/3038 15/18639 0.333333333333333 2.04509545753785 0.0829583941648475 0.648050178235389 GO:0048531 beta-1,3-galactosyltransferase activity 5/3038 15/18639 0.333333333333333 2.04509545753785 0.0829583941648475 0.648050178235389 GO:0051371 muscle alpha-actinin binding 5/3038 15/18639 0.333333333333333 2.04509545753785 0.0829583941648475 0.648050178235389 GO:0140776 protein-containing complex destabilizing activity 5/3038 15/18639 0.333333333333333 2.04509545753785 0.0829583941648475 0.648050178235389 GO:0051015 actin filament binding 42/3038 209/18639 0.200956937799043 1.23292836196062 0.0833392887345249 0.648050178235389 GO:0017171 serine hydrolase activity 40/3038 198/18639 0.202020202020202 1.23945179244718 0.0837124951840814 0.648050178235389 GO:0003953 NAD+ nucleosidase activity 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0004143 ATP-dependent diacylglycerol kinase activity 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0005114 type II transforming growth factor beta receptor binding 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0010854 adenylate cyclase regulator activity 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0034713 type I transforming growth factor beta receptor binding 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0050998 nitric-oxide synthase binding 4/3038 11/18639 0.363636363636364 2.23101322640493 0.0893513094163783 0.661059688414738 GO:0045296 cadherin binding 64/3038 334/18639 0.191616766467066 1.17562373606966 0.0897302809806872 0.661059688414738 GO:0015035 protein-disulfide reductase activity 9/3038 34/18639 0.264705882352941 1.62404639275065 0.0898098908536726 0.661059688414738 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 10/3038 39/18639 0.256410256410256 1.57315035195219 0.0911211704939658 0.663518622233542 GO:0030020 extracellular matrix structural constituent conferring tensile strength 11/3038 44/18639 0.25 1.53382159315339 0.0915140759178555 0.663518622233542 GO:0048306 calcium-dependent protein binding 18/3038 80/18639 0.225 1.38043943383805 0.0916217251191082 0.663518622233542 GO:0015095 magnesium ion transmembrane transporter activity 6/3038 20/18639 0.3 1.84058591178407 0.0933746705534602 0.665479794896883 GO:0016004 phospholipase activator activity 6/3038 20/18639 0.3 1.84058591178407 0.0933746705534602 0.665479794896883 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 6/3038 20/18639 0.3 1.84058591178407 0.0933746705534602 0.665479794896883 GO:0097110 scaffold protein binding 16/3038 70/18639 0.228571428571429 1.4023511708831 0.0959729254977206 0.680397529712788 GO:0050660 flavin adenine dinucleotide binding 19/3038 86/18639 0.22093023255814 1.3554702451123 0.0979904350430522 0.687674740581884 GO:0038024 cargo receptor activity 15/3038 65/18639 0.230769230769231 1.41583531675698 0.0980281957739991 0.687674740581884 GO:0004713 protein tyrosine kinase activity 29/3038 140/18639 0.207142857142857 1.27088074861281 0.098530976193247 0.687674740581884 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 7/3038 25/18639 0.28 1.7178801843318 0.0993955744644277 0.690133189709196 GO:0016247 channel regulator activity 34/3038 168/18639 0.202380952380952 1.24166509921941 0.101873217894863 0.694175490360821 GO:0070566 adenylyltransferase activity 8/3038 30/18639 0.266666666666667 1.63607636603028 0.102697715311203 0.694175490360821 GO:0046915 transition metal ion transmembrane transporter activity 11/3038 45/18639 0.244444444444444 1.49973666886109 0.104129118044088 0.694175490360821 GO:0005343 organic acid:sodium symporter activity 9/3038 35/18639 0.257142857142857 1.57764506724349 0.104236224896141 0.694175490360821 GO:0016229 steroid dehydrogenase activity 9/3038 35/18639 0.257142857142857 1.57764506724349 0.104236224896141 0.694175490360821 GO:0005126 cytokine receptor binding 53/3038 275/18639 0.192727272727273 1.18243700999461 0.105020519955025 0.694175490360821 GO:0005024 transforming growth factor beta receptor activity 5/3038 16/18639 0.3125 1.91727699144174 0.10513125466489 0.694175490360821 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/3038 16/18639 0.3125 1.91727699144174 0.10513125466489 0.694175490360821 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 5/3038 16/18639 0.3125 1.91727699144174 0.10513125466489 0.694175490360821 GO:0097027 ubiquitin-protein transferase activator activity 5/3038 16/18639 0.3125 1.91727699144174 0.10513125466489 0.694175490360821 GO:0015291 secondary active transmembrane transporter activity 55/3038 287/18639 0.191637630662021 1.17575174388065 0.108373417345292 0.712092649581016 GO:0016758 hexosyltransferase activity 39/3038 197/18639 0.197969543147208 1.2145998402636 0.109422494292675 0.713664342595581 GO:0004725 protein tyrosine phosphatase activity 21/3038 98/18639 0.214285714285714 1.31470422270291 0.10967224863941 0.713664342595581 GO:0170055 lipid transmembrane transporter activity 13/3038 56/18639 0.232142857142857 1.42426290792815 0.11361261853745 0.724539959289743 GO:0042379 chemokine receptor binding 16/3038 72/18639 0.222222222222222 1.3633969716919 0.11670280582293 0.724539959289743 GO:0004300 enoyl-CoA hydratase activity 4/3038 12/18639 0.333333333333333 2.04509545753785 0.117398135538361 0.724539959289743 GO:0005527 macrolide binding 4/3038 12/18639 0.333333333333333 2.04509545753785 0.117398135538361 0.724539959289743 GO:0015269 calcium-activated potassium channel activity 4/3038 12/18639 0.333333333333333 2.04509545753785 0.117398135538361 0.724539959289743 GO:0016208 AMP binding 4/3038 12/18639 0.333333333333333 2.04509545753785 0.117398135538361 0.724539959289743 GO:0045295 gamma-catenin binding 4/3038 12/18639 0.333333333333333 2.04509545753785 0.117398135538361 0.724539959289743 GO:0030276 clathrin binding 11/3038 46/18639 0.239130434782609 1.4671336977989 0.11770803940898 0.724539959289743 GO:0004435 phosphatidylinositol phospholipase C activity 7/3038 26/18639 0.269230769230769 1.65180786954981 0.117805464559788 0.724539959289743 GO:0008198 ferrous iron binding 7/3038 26/18639 0.269230769230769 1.65180786954981 0.117805464559788 0.724539959289743 GO:0005484 SNAP receptor activity 9/3038 36/18639 0.25 1.53382159315339 0.119892267294233 0.724539959289743 GO:0045505 dynein intermediate chain binding 9/3038 36/18639 0.25 1.53382159315339 0.119892267294233 0.724539959289743 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 9/3038 36/18639 0.25 1.53382159315339 0.119892267294233 0.724539959289743 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 9/3038 36/18639 0.25 1.53382159315339 0.119892267294233 0.724539959289743 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 9/3038 36/18639 0.25 1.53382159315339 0.119892267294233 0.724539959289743 GO:0008173 RNA methyltransferase activity 15/3038 67/18639 0.223880597014925 1.37357157595826 0.119949822510477 0.724539959289743 GO:0004857 enzyme inhibitor activity 77/3038 416/18639 0.185096153846154 1.13561791031549 0.122461501457023 0.736409118136654 GO:0046943 carboxylic acid transmembrane transporter activity 37/3038 188/18639 0.196808510638298 1.20747657333352 0.123792469799592 0.741104252533556 GO:0015932 nucleobase-containing compound transmembrane transporter activity 13/3038 57/18639 0.228070175438596 1.39927583936801 0.126344490927024 0.750381868195351 GO:0008236 serine-type peptidase activity 38/3038 194/18639 0.195876288659794 1.20175712453255 0.126456335620152 0.750381868195351 GO:0016829 lyase activity 39/3038 200/18639 0.195 1.19638084265964 0.129027106524613 0.760646293806232 GO:0048038 quinone binding 5/3038 17/18639 0.294117647058824 1.80449599194517 0.129880213493269 0.760646293806232 GO:0070492 oligosaccharide binding 5/3038 17/18639 0.294117647058824 1.80449599194517 0.129880213493269 0.760646293806232 GO:0005342 organic acid transmembrane transporter activity 37/3038 189/18639 0.195767195767196 1.20108780839525 0.130818849097869 0.762826795388872 GO:0003777 microtubule motor activity 15/3038 68/18639 0.220588235294118 1.35337199395887 0.131902895344094 0.76583275874351 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 44/3038 229/18639 0.192139737991266 1.17883231613536 0.133949194230266 0.769411230325175 GO:0033293 monocarboxylic acid binding 17/3038 79/18639 0.215189873417722 1.32025149790418 0.135401853654607 0.769411230325175 GO:0008649 rRNA methyltransferase activity 6/3038 22/18639 0.272727272727273 1.6732599198037 0.135658016521135 0.769411230325175 GO:0070034 telomerase RNA binding 6/3038 22/18639 0.272727272727273 1.6732599198037 0.135658016521135 0.769411230325175 GO:0140784 metal ion sensor activity 6/3038 22/18639 0.272727272727273 1.6732599198037 0.135658016521135 0.769411230325175 GO:0005044 scavenger receptor activity 7/3038 27/18639 0.259259259259259 1.59062980030722 0.137841019263796 0.769411230325175 GO:0035255 ionotropic glutamate receptor binding 7/3038 27/18639 0.259259259259259 1.59062980030722 0.137841019263796 0.769411230325175 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/3038 32/18639 0.25 1.53382159315339 0.137932678917495 0.769411230325175 GO:0042910 xenobiotic transmembrane transporter activity 8/3038 32/18639 0.25 1.53382159315339 0.137932678917495 0.769411230325175 GO:0005516 calmodulin binding 40/3038 207/18639 0.193236714975845 1.18556258407992 0.13848100323178 0.769411230325175 GO:0043022 ribosome binding 23/3038 112/18639 0.205357142857143 1.25992488009028 0.138802471394965 0.769411230325175 GO:0032266 phosphatidylinositol-3-phosphate binding 11/3038 48/18639 0.229166666666667 1.40600312705727 0.147681934232998 0.794851936865381 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0005035 death receptor activity 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0005172 vascular endothelial growth factor receptor binding 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0017154 semaphorin receptor activity 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0031994 insulin-like growth factor I binding 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0035325 Toll-like receptor binding 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/3038 13/18639 0.307692307692308 1.88778042234263 0.148702812242076 0.794851936865381 GO:0048156 tau protein binding 10/3038 43/18639 0.232558139534884 1.42681078432874 0.151376632086555 0.805155870925233 GO:0004721 phosphoprotein phosphatase activity 34/3038 175/18639 0.194285714285714 1.19199849525063 0.153131836410416 0.805155870925233 GO:0044325 transmembrane transporter binding 27/3038 136/18639 0.198529411764706 1.21803479456299 0.156199075097619 0.805155870925233 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 5/3038 18/18639 0.277777777777778 1.70424621461488 0.156973047552178 0.805155870925233 GO:0015172 acidic amino acid transmembrane transporter activity 5/3038 18/18639 0.277777777777778 1.70424621461488 0.156973047552178 0.805155870925233 GO:0017075 syntaxin-1 binding 5/3038 18/18639 0.277777777777778 1.70424621461488 0.156973047552178 0.805155870925233 GO:0034185 apolipoprotein binding 5/3038 18/18639 0.277777777777778 1.70424621461488 0.156973047552178 0.805155870925233 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/3038 33/18639 0.242424242424242 1.48734215093662 0.157548684936018 0.805155870925233 GO:0140416 transcription regulator inhibitor activity 8/3038 33/18639 0.242424242424242 1.48734215093662 0.157548684936018 0.805155870925233 GO:0004022 alcohol dehydrogenase (NAD+) activity 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:0004602 glutathione peroxidase activity 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:0005158 insulin receptor binding 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:0016849 phosphorus-oxygen lyase activity 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:0140102 catalytic activity, acting on a rRNA 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 6/3038 23/18639 0.260869565217391 1.60050948850789 0.159639684121549 0.805155870925233 GO:0052689 carboxylic ester hydrolase activity 19/3038 92/18639 0.206521739130435 1.26707001173541 0.160194338090544 0.805155870925233 GO:0016790 thiolester hydrolase activity 10/3038 44/18639 0.227272727272727 1.39438326650308 0.16898326625382 0.832960481913705 GO:0035401 histone H3Y41 kinase activity 23/3038 115/18639 0.2 1.22705727452271 0.169843527688926 0.832960481913705 GO:0140801 histone H2AXY142 kinase activity 23/3038 115/18639 0.2 1.22705727452271 0.169843527688926 0.832960481913705 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 9/3038 39/18639 0.230769230769231 1.41583531675698 0.173830129358027 0.832960481913705 GO:0008175 tRNA methyltransferase activity 8/3038 34/18639 0.235294117647059 1.44359679355613 0.178391390807509 0.832960481913705 GO:0005319 lipid transporter activity 34/3038 178/18639 0.191011235955056 1.17190863297113 0.179010031648354 0.832960481913705 GO:0044389 ubiquitin-like protein ligase binding 59/3038 322/18639 0.183229813664596 1.12416737883292 0.17914045486799 0.832960481913705 GO:0004181 metallocarboxypeptidase activity 7/3038 29/18639 0.241379310344828 1.48093119338948 0.18238231234362 0.832960481913705 GO:0004629 phospholipase C activity 7/3038 29/18639 0.241379310344828 1.48093119338948 0.18238231234362 0.832960481913705 GO:0005416 amino acid:monoatomic cation symporter activity 7/3038 29/18639 0.241379310344828 1.48093119338948 0.18238231234362 0.832960481913705 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/3038 29/18639 0.241379310344828 1.48093119338948 0.18238231234362 0.832960481913705 GO:0051861 glycolipid binding 7/3038 29/18639 0.241379310344828 1.48093119338948 0.18238231234362 0.832960481913705 GO:0016874 ligase activity 32/3038 167/18639 0.191616766467066 1.17562373606966 0.182562199493596 0.832960481913705 GO:0005347 ATP transmembrane transporter activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0008174 mRNA methyltransferase activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0008559 ABC-type xenobiotic transporter activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0019992 diacylglycerol binding 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0031404 chloride ion binding 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0061665 SUMO ligase activity 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0071933 Arp2/3 complex binding 4/3038 14/18639 0.285714285714286 1.75293896360387 0.182769883804065 0.832960481913705 GO:0019905 syntaxin binding 13/3038 61/18639 0.213114754098361 1.30752004662256 0.184751503928626 0.832960481913705 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/3038 24/18639 0.25 1.53382159315339 0.185292041357118 0.832960481913705 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/3038 24/18639 0.25 1.53382159315339 0.185292041357118 0.832960481913705 GO:0005315 phosphate transmembrane transporter activity 6/3038 24/18639 0.25 1.53382159315339 0.185292041357118 0.832960481913705 GO:0035035 histone acetyltransferase binding 6/3038 24/18639 0.25 1.53382159315339 0.185292041357118 0.832960481913705 GO:0030165 PDZ domain binding 17/3038 83/18639 0.204819277108434 1.25662491969193 0.185894191973362 0.832960481913705 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/3038 19/18639 0.263157894736842 1.61454904542462 0.18613296589163 0.832960481913705 GO:0005346 purine ribonucleotide transmembrane transporter activity 5/3038 19/18639 0.263157894736842 1.61454904542462 0.18613296589163 0.832960481913705 GO:0005520 insulin-like growth factor binding 5/3038 19/18639 0.263157894736842 1.61454904542462 0.18613296589163 0.832960481913705 GO:0031420 alkali metal ion binding 5/3038 19/18639 0.263157894736842 1.61454904542462 0.18613296589163 0.832960481913705 GO:0042577 lipid phosphatase activity 5/3038 19/18639 0.263157894736842 1.61454904542462 0.18613296589163 0.832960481913705 GO:0008083 growth factor activity 31/3038 162/18639 0.191358024691358 1.17403628117914 0.189194103116071 0.840685230380974 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 18/3038 89/18639 0.202247191011236 1.24084443491061 0.192107841122374 0.840685230380974 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 18/3038 89/18639 0.202247191011236 1.24084443491061 0.192107841122374 0.840685230380974 GO:0071949 FAD binding 9/3038 40/18639 0.225 1.38043943383805 0.193932021113577 0.840685230380974 GO:0016597 amino acid binding 11/3038 51/18639 0.215686274509804 1.32329706075979 0.199181212500867 0.840685230380974 GO:0061631 ubiquitin conjugating enzyme activity 8/3038 35/18639 0.228571428571429 1.4023511708831 0.200363291818284 0.840685230380974 GO:0004521 RNA endonuclease activity 15/3038 73/18639 0.205479452054795 1.26067528204388 0.201048391974726 0.840685230380974 GO:0015179 L-amino acid transmembrane transporter activity 13/3038 62/18639 0.209677419354839 1.28643101361252 0.201087447658866 0.840685230380974 GO:0015297 antiporter activity 26/3038 135/18639 0.192592592592593 1.18161070879965 0.20426176960819 0.840685230380974 GO:0140793 histone H2AXY142 phosphatase activity 18/3038 90/18639 0.2 1.22705727452271 0.205767534313086 0.840685230380974 GO:0022839 monoatomic ion-gated channel activity 7/3038 30/18639 0.233333333333333 1.4315668202765 0.206634146223052 0.840685230380974 GO:0031624 ubiquitin conjugating enzyme binding 7/3038 30/18639 0.233333333333333 1.4315668202765 0.206634146223052 0.840685230380974 GO:0001664 G protein-coupled receptor binding 54/3038 297/18639 0.181818181818182 1.11550661320247 0.208267490189182 0.840685230380974 GO:0003707 nuclear steroid receptor activity 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0005537 D-mannose binding 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0015271 outward rectifier potassium channel activity 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0019211 phosphatase activator activity 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0047617 fatty acyl-CoA hydrolase activity 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/3038 25/18639 0.24 1.47246872942725 0.212417241428494 0.840685230380974 GO:0004382 GDP phosphatase activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0004955 prostaglandin receptor activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0008239 dipeptidyl-peptidase activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0016427 tRNA (cytidine) methyltransferase activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0030957 Tat protein binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0031419 cobalamin binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0032356 oxidized DNA binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0043121 neurotrophin binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0047429 nucleoside triphosphate diphosphatase activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0097177 mitochondrial ribosome binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0098505 G-rich strand telomeric DNA binding 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:1990757 ubiquitin ligase activator activity 3/3038 10/18639 0.3 1.84058591178407 0.214546762943481 0.840685230380974 GO:0001727 lipid kinase activity 9/3038 41/18639 0.219512195121951 1.3467701793542 0.214967187966226 0.840685230380974 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/3038 41/18639 0.219512195121951 1.3467701793542 0.214967187966226 0.840685230380974 GO:0061650 ubiquitin-like protein conjugating enzyme activity 9/3038 41/18639 0.219512195121951 1.3467701793542 0.214967187966226 0.840685230380974 GO:0016779 nucleotidyltransferase activity 26/3038 136/18639 0.191176470588235 1.17292239476436 0.215622042856144 0.840685230380974 GO:0140789 histone phosphatase activity 26/3038 136/18639 0.191176470588235 1.17292239476436 0.215622042856144 0.840685230380974 GO:0015171 amino acid transmembrane transporter activity 20/3038 102/18639 0.196078431372549 1.20299732796344 0.216209823760518 0.840685230380974 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/3038 20/18639 0.25 1.53382159315339 0.217052397671019 0.840685230380974 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 5/3038 20/18639 0.25 1.53382159315339 0.217052397671019 0.840685230380974 GO:0010851 cyclase regulator activity 5/3038 20/18639 0.25 1.53382159315339 0.217052397671019 0.840685230380974 GO:0016408 C-acyltransferase activity 5/3038 20/18639 0.25 1.53382159315339 0.217052397671019 0.840685230380974 GO:0004953 icosanoid receptor activity 4/3038 15/18639 0.266666666666667 1.63607636603028 0.219064970945599 0.840685230380974 GO:0016846 carbon-sulfur lyase activity 4/3038 15/18639 0.266666666666667 1.63607636603028 0.219064970945599 0.840685230380974 GO:0033130 acetylcholine receptor binding 4/3038 15/18639 0.266666666666667 1.63607636603028 0.219064970945599 0.840685230380974 GO:0045504 dynein heavy chain binding 4/3038 15/18639 0.266666666666667 1.63607636603028 0.219064970945599 0.840685230380974 GO:0061578 K63-linked deubiquitinase activity 4/3038 15/18639 0.266666666666667 1.63607636603028 0.219064970945599 0.840685230380974 GO:0044390 ubiquitin-like protein conjugating enzyme binding 8/3038 36/18639 0.222222222222222 1.3633969716919 0.223355013110871 0.854713643921429 GO:0002039 p53 binding 14/3038 69/18639 0.202898550724638 1.24484071328391 0.225785012067482 0.861564904404811 GO:0043495 protein-membrane adaptor activity 10/3038 47/18639 0.212765957446809 1.30538007927948 0.227084157076715 0.861640449527704 GO:0140359 ABC-type transporter activity 10/3038 47/18639 0.212765957446809 1.30538007927948 0.227084157076715 0.861640449527704 GO:0005452 solute:inorganic anion antiporter activity 7/3038 31/18639 0.225806451612903 1.38538724542887 0.232011320451502 0.871865948385511 GO:0072349 modified amino acid transmembrane transporter activity 7/3038 31/18639 0.225806451612903 1.38538724542887 0.232011320451502 0.871865948385511 GO:0016859 cis-trans isomerase activity 9/3038 42/18639 0.214285714285714 1.31470422270291 0.23684532576189 0.871865948385511 GO:0017046 peptide hormone binding 11/3038 53/18639 0.207547169811321 1.27336132261791 0.237312035368094 0.871865948385511 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0005227 calcium-activated cation channel activity 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0016289 acyl-CoA hydrolase activity 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0030507 spectrin binding 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0050750 low-density lipoprotein particle receptor binding 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0070006 metalloaminopeptidase activity 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0070412 R-SMAD binding 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0097602 cullin family protein binding 6/3038 26/18639 0.230769230769231 1.41583531675698 0.240800774489105 0.871865948385511 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 31/3038 167/18639 0.18562874251497 1.13888549431749 0.241185001206965 0.871865948385511 GO:0008028 monocarboxylic acid transmembrane transporter activity 14/3038 70/18639 0.2 1.22705727452271 0.242796094219124 0.871865948385511 GO:0001786 phosphatidylserine binding 12/3038 59/18639 0.203389830508475 1.24785485544683 0.246067716638102 0.871865948385511 GO:0043394 proteoglycan binding 8/3038 37/18639 0.216216216216216 1.32654840488942 0.247247716224792 0.871865948385511 GO:0140375 immune receptor activity 29/3038 156/18639 0.185897435897436 1.14053400516534 0.247546785087756 0.871865948385511 GO:0031625 ubiquitin protein ligase binding 54/3038 302/18639 0.178807947019868 1.097037960666 0.247918901993069 0.871865948385511 GO:0016879 ligase activity, forming carbon-nitrogen bonds 10/3038 48/18639 0.208333333333333 1.27818466096116 0.247979478877693 0.871865948385511 GO:0017022 myosin binding 15/3038 76/18639 0.197368421052632 1.21091178406847 0.249178160992485 0.871865948385511 GO:0015174 basic amino acid transmembrane transporter activity 5/3038 21/18639 0.238095238095238 1.4607824696699 0.249405790959701 0.871865948385511 GO:0061891 calcium ion sensor activity 5/3038 21/18639 0.238095238095238 1.4607824696699 0.249405790959701 0.871865948385511 GO:0072542 protein phosphatase activator activity 5/3038 21/18639 0.238095238095238 1.4607824696699 0.249405790959701 0.871865948385511 GO:0120013 lipid transfer activity 13/3038 65/18639 0.2 1.22705727452271 0.25365131544828 0.871865948385511 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 23/3038 122/18639 0.188524590163934 1.15665234893534 0.254949308224717 0.871865948385511 GO:0005159 insulin-like growth factor receptor binding 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0008142 oxysterol binding 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0017070 U6 snRNA binding 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0022858 alanine transmembrane transporter activity 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0034450 ubiquitin-ubiquitin ligase activity 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0070411 I-SMAD binding 4/3038 16/18639 0.25 1.53382159315339 0.257042876372502 0.871865948385511 GO:0008378 galactosyltransferase activity 7/3038 32/18639 0.21875 1.34209389400922 0.258353340081024 0.871865948385511 GO:0015106 bicarbonate transmembrane transporter activity 7/3038 32/18639 0.21875 1.34209389400922 0.258353340081024 0.871865948385511 GO:0008200 ion channel inhibitor activity 9/3038 43/18639 0.209302325581395 1.28412970589586 0.259469391734773 0.871865948385511 GO:0000099 sulfur amino acid transmembrane transporter activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0004954 prostanoid receptor activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0005225 volume-sensitive anion channel activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0008172 S-methyltransferase activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0008199 ferric iron binding 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0008271 secondary active sulfate transmembrane transporter activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0015217 ADP transmembrane transporter activity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0032794 GTPase activating protein binding 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0045294 alpha-catenin binding 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0070990 snRNP binding 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0097493 structural molecule activity conferring elasticity 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/3038 11/18639 0.272727272727273 1.6732599198037 0.261495058016144 0.871865948385511 GO:0008168 methyltransferase activity 37/3038 204/18639 0.181372549019608 1.11277252836619 0.26362224964413 0.876788074742327 GO:0004175 endopeptidase activity 71/3038 405/18639 0.175308641975309 1.0755687221125 0.267757247140744 0.879606247553314 GO:0005385 zinc ion transmembrane transporter activity 6/3038 27/18639 0.222222222222222 1.3633969716919 0.270217847410622 0.879606247553314 GO:0008320 protein transmembrane transporter activity 6/3038 27/18639 0.222222222222222 1.3633969716919 0.270217847410622 0.879606247553314 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 6/3038 27/18639 0.222222222222222 1.3633969716919 0.270217847410622 0.879606247553314 GO:0023026 MHC class II protein complex binding 6/3038 27/18639 0.222222222222222 1.3633969716919 0.270217847410622 0.879606247553314 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 6/3038 27/18639 0.222222222222222 1.3633969716919 0.270217847410622 0.879606247553314 GO:0043531 ADP binding 8/3038 38/18639 0.210526315789474 1.2916392363397 0.271915521473205 0.879606247553314 GO:0004497 monooxygenase activity 20/3038 106/18639 0.188679245283019 1.15760120237992 0.272502026755487 0.879606247553314 GO:0140313 molecular sequestering activity 11/3038 55/18639 0.2 1.22705727452271 0.27790891374771 0.879606247553314 GO:0015085 calcium ion transmembrane transporter activity 27/3038 147/18639 0.183673469387755 1.12688933374535 0.278910328284976 0.879606247553314 GO:0016248 channel inhibitor activity 9/3038 44/18639 0.204545454545455 1.25494493985277 0.282737252572732 0.879606247553314 GO:0030547 signaling receptor inhibitor activity 9/3038 44/18639 0.204545454545455 1.25494493985277 0.282737252572732 0.879606247553314 GO:0008093 cytoskeletal anchor activity 5/3038 22/18639 0.227272727272727 1.39438326650308 0.28286101873575 0.879606247553314 GO:0033691 sialic acid binding 5/3038 22/18639 0.227272727272727 1.39438326650308 0.28286101873575 0.879606247553314 GO:0034062 5'-3' RNA polymerase activity 5/3038 22/18639 0.227272727272727 1.39438326650308 0.28286101873575 0.879606247553314 GO:0061133 endopeptidase activator activity 5/3038 22/18639 0.227272727272727 1.39438326650308 0.28286101873575 0.879606247553314 GO:0097747 RNA polymerase activity 5/3038 22/18639 0.227272727272727 1.39438326650308 0.28286101873575 0.879606247553314 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 12/3038 61/18639 0.19672131147541 1.20694158149775 0.285045344847463 0.879606247553314 GO:0043021 ribonucleoprotein complex binding 32/3038 177/18639 0.180790960451977 1.10920431595273 0.288519405017512 0.879606247553314 GO:0000287 magnesium ion binding 41/3038 230/18639 0.178260869565217 1.09368148381372 0.289504495429167 0.879606247553314 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 13/3038 67/18639 0.194029850746269 1.19042869916383 0.291182783829677 0.879606247553314 GO:0042054 histone methyltransferase activity 13/3038 67/18639 0.194029850746269 1.19042869916383 0.291182783829677 0.879606247553314 GO:0003924 GTPase activity 58/3038 331/18639 0.175226586102719 1.07506528583561 0.293030392904763 0.879606247553314 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0004549 tRNA-specific ribonuclease activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0005092 GDP-dissociation inhibitor activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0008569 minus-end-directed microtubule motor activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0017110 nucleoside diphosphate phosphatase activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0019198 transmembrane receptor protein phosphatase activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0030548 acetylcholine receptor regulator activity 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0051787 misfolded protein binding 4/3038 17/18639 0.235294117647059 1.44359679355613 0.296169849566112 0.879606247553314 GO:0043539 protein serine/threonine kinase activator activity 14/3038 73/18639 0.191780821917808 1.17663026324096 0.296515500838851 0.879606247553314 GO:0005262 calcium channel activity 24/3038 131/18639 0.183206106870229 1.1240219308605 0.298344592340067 0.879606247553314 GO:0008201 heparin binding 31/3038 172/18639 0.180232558139535 1.10577835785477 0.298735025290207 0.879606247553314 GO:0016866 intramolecular transferase activity 6/3038 28/18639 0.214285714285714 1.31470422270291 0.300439273214026 0.879606247553314 GO:0019789 SUMO transferase activity 6/3038 28/18639 0.214285714285714 1.31470422270291 0.300439273214026 0.879606247553314 GO:0051119 sugar transmembrane transporter activity 6/3038 28/18639 0.214285714285714 1.31470422270291 0.300439273214026 0.879606247553314 GO:0051959 dynein light intermediate chain binding 6/3038 28/18639 0.214285714285714 1.31470422270291 0.300439273214026 0.879606247553314 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/3038 28/18639 0.214285714285714 1.31470422270291 0.300439273214026 0.879606247553314 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/3038 45/18639 0.2 1.22705727452271 0.306543309994623 0.879606247553314 GO:0141110 transporter inhibitor activity 9/3038 45/18639 0.2 1.22705727452271 0.306543309994623 0.879606247553314 GO:0061134 peptidase regulator activity 40/3038 226/18639 0.176991150442478 1.08589139338293 0.309321509233368 0.879606247553314 GO:0003995 acyl-CoA dehydrogenase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0005025 transforming growth factor beta receptor activity, type I 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0005026 transforming growth factor beta receptor activity, type II 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0008603 cAMP-dependent protein kinase regulator activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0010853 cyclase activator activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0015166 polyol transmembrane transporter activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0016361 activin receptor activity, type I 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0016362 activin receptor activity, type II 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0016801 hydrolase activity, acting on ether bonds 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0016803 ether hydrolase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0017002 activin receptor activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0017166 vinculin binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0034452 dynactin binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0035259 nuclear glucocorticoid receptor binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0035497 cAMP response element binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0043047 single-stranded telomeric DNA binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0070410 co-SMAD binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0097677 STAT family protein binding 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0140900 chloride:bicarbonate antiporter activity 3/3038 12/18639 0.25 1.53382159315339 0.309527365508739 0.879606247553314 GO:0008376 acetylgalactosaminyltransferase activity 7/3038 34/18639 0.205882352941176 1.26314719436162 0.313260153033006 0.88613922877981 GO:0052866 phosphatidylinositol phosphate phosphatase activity 7/3038 34/18639 0.205882352941176 1.26314719436162 0.313260153033006 0.88613922877981 GO:0005272 sodium channel activity 10/3038 51/18639 0.196078431372549 1.20299732796344 0.314122529713882 0.88613922877981 GO:0000295 adenine nucleotide transmembrane transporter activity 5/3038 23/18639 0.217391304347826 1.3337579070899 0.317089167239694 0.88613922877981 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 5/3038 23/18639 0.217391304347826 1.3337579070899 0.317089167239694 0.88613922877981 GO:0016493 C-C chemokine receptor activity 5/3038 23/18639 0.217391304347826 1.3337579070899 0.317089167239694 0.88613922877981 GO:0031681 G-protein beta-subunit binding 5/3038 23/18639 0.217391304347826 1.3337579070899 0.317089167239694 0.88613922877981 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/3038 23/18639 0.217391304347826 1.3337579070899 0.317089167239694 0.88613922877981 GO:0015144 carbohydrate transmembrane transporter activity 8/3038 40/18639 0.2 1.22705727452271 0.323051845632524 0.900933408006232 GO:0016853 isomerase activity 32/3038 180/18639 0.177777777777778 1.09071757735352 0.324130496839347 0.90207392405496 GO:0043178 alcohol binding 17/3038 92/18639 0.184782608695652 1.13369422102642 0.325892577340079 0.9041931153986 GO:0008194 UDP-glycosyltransferase activity 26/3038 145/18639 0.179310344827586 1.10012031508933 0.329403237081271 0.9041931153986 GO:0003785 actin monomer binding 6/3038 29/18639 0.206896551724138 1.26936959433384 0.331236741267176 0.9041931153986 GO:0099604 ligand-gated calcium channel activity 6/3038 29/18639 0.206896551724138 1.26936959433384 0.331236741267176 0.9041931153986 GO:0003725 double-stranded RNA binding 14/3038 75/18639 0.186666666666667 1.1452534562212 0.334099667193549 0.9041931153986 GO:0019003 GDP binding 14/3038 75/18639 0.186666666666667 1.1452534562212 0.334099667193549 0.9041931153986 GO:0000400 four-way junction DNA binding 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0004706 JUN kinase kinase kinase activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0004970 glutamate-gated receptor activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0015280 ligand-gated sodium channel activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0016854 racemase and epimerase activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0050811 GABA receptor binding 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0099602 neurotransmitter receptor regulator activity 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:1990381 ubiquitin-specific protease binding 4/3038 18/18639 0.222222222222222 1.3633969716919 0.335940364427236 0.9041931153986 GO:0005080 protein kinase C binding 10/3038 52/18639 0.192307692307692 1.17986276396415 0.337031407123713 0.9041931153986 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 10/3038 52/18639 0.192307692307692 1.17986276396415 0.337031407123713 0.9041931153986 GO:0046873 metal ion transmembrane transporter activity 77/3038 450/18639 0.171111111111111 1.04981566820276 0.337645981474013 0.9041931153986 GO:0005154 epidermal growth factor receptor binding 7/3038 35/18639 0.2 1.22705727452271 0.341484368336686 0.909287855311943 GO:0043015 gamma-tubulin binding 7/3038 35/18639 0.2 1.22705727452271 0.341484368336686 0.909287855311943 GO:0015293 symporter activity 26/3038 146/18639 0.178082191780822 1.09258524443803 0.343047044134862 0.909287855311943 GO:0015175 neutral L-amino acid transmembrane transporter activity 8/3038 41/18639 0.195121951219512 1.19712904831484 0.34925418688496 0.909287855311943 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/3038 41/18639 0.195121951219512 1.19712904831484 0.34925418688496 0.909287855311943 GO:0004806 triacylglycerol lipase activity 5/3038 24/18639 0.208333333333333 1.27818466096116 0.35177262141932 0.909287855311943 GO:0015149 hexose transmembrane transporter activity 5/3038 24/18639 0.208333333333333 1.27818466096116 0.35177262141932 0.909287855311943 GO:0050699 WW domain binding 5/3038 24/18639 0.208333333333333 1.27818466096116 0.35177262141932 0.909287855311943 GO:0055056 D-glucose transmembrane transporter activity 5/3038 24/18639 0.208333333333333 1.27818466096116 0.35177262141932 0.909287855311943 GO:0070300 phosphatidic acid binding 5/3038 24/18639 0.208333333333333 1.27818466096116 0.35177262141932 0.909287855311943 GO:0005085 guanyl-nucleotide exchange factor activity 40/3038 230/18639 0.173913043478261 1.06700632567192 0.352573857461013 0.909287855311943 GO:0005504 fatty acid binding 9/3038 47/18639 0.191489361702128 1.17484207135153 0.355339628494273 0.909287855311943 GO:0004465 lipoprotein lipase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0008253 5'-nucleotidase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0009982 pseudouridine synthase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0019104 DNA N-glycosylase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0019855 calcium channel inhibitor activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0030955 potassium ion binding 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0035673 oligopeptide transmembrane transporter activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0043560 insulin receptor substrate binding 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0046975 histone H3K36 methyltransferase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0070123 transforming growth factor beta receptor activity, type III 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0070700 BMP receptor binding 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0071714 icosanoid transmembrane transporter activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/3038 13/18639 0.230769230769231 1.41583531675698 0.357774731488738 0.909287855311943 GO:0016860 intramolecular oxidoreductase activity 10/3038 53/18639 0.188679245283019 1.15760120237992 0.360221958694787 0.91239735144676 GO:0042562 hormone binding 17/3038 94/18639 0.180851063829787 1.10957306738756 0.360352925738438 0.91239735144676 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/3038 30/18639 0.2 1.22705727452271 0.362387390028207 0.915827043842391 GO:0004879 nuclear receptor activity 11/3038 59/18639 0.186440677966102 1.14386695082626 0.364211794195076 0.916996797721062 GO:0015459 potassium channel regulator activity 11/3038 59/18639 0.186440677966102 1.14386695082626 0.364211794195076 0.916996797721062 GO:0005267 potassium channel activity 22/3038 124/18639 0.17741935483871 1.08851854997983 0.367443690763965 0.92069693769997 GO:0160215 deacylase activity 12/3038 65/18639 0.184615384615385 1.13266825340558 0.367519474936594 0.92069693769997 GO:0016298 lipase activity 23/3038 130/18639 0.176923076923077 1.08547374284701 0.368415478411495 0.92069693769997 GO:0016798 hydrolase activity, acting on glycosyl bonds 23/3038 130/18639 0.176923076923077 1.08547374284701 0.368415478411495 0.92069693769997 GO:0048487 beta-tubulin binding 8/3038 42/18639 0.19047619047619 1.16862597573592 0.375703330678624 0.930739868451245 GO:0008574 plus-end-directed microtubule motor activity 4/3038 19/18639 0.210526315789474 1.2916392363397 0.375889004036731 0.930739868451245 GO:0042800 histone H3K4 methyltransferase activity 4/3038 19/18639 0.210526315789474 1.2916392363397 0.375889004036731 0.930739868451245 GO:0043395 heparan sulfate proteoglycan binding 4/3038 19/18639 0.210526315789474 1.2916392363397 0.375889004036731 0.930739868451245 GO:0120227 acyl-CoA binding 4/3038 19/18639 0.210526315789474 1.2916392363397 0.375889004036731 0.930739868451245 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/3038 48/18639 0.1875 1.15036619486504 0.380115047636561 0.938316477952675 GO:0017069 snRNA binding 10/3038 54/18639 0.185185185185185 1.13616414307659 0.383605059698435 0.938316477952675 GO:1901681 sulfur compound binding 47/3038 275/18639 0.170909090909091 1.04857621641032 0.38500703556235 0.938316477952675 GO:0016741 transferase activity, transferring one-carbon groups 37/3038 215/18639 0.172093023255814 1.05583998040326 0.386163357263095 0.938316477952675 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/3038 60/18639 0.183333333333333 1.12480250164582 0.386413023540521 0.938316477952675 GO:0098531 ligand-modulated transcription factor activity 11/3038 60/18639 0.183333333333333 1.12480250164582 0.386413023540521 0.938316477952675 GO:0004709 MAP kinase kinase kinase activity 5/3038 25/18639 0.2 1.22705727452271 0.386611466417026 0.938316477952675 GO:0015645 fatty acid ligase activity 5/3038 25/18639 0.2 1.22705727452271 0.386611466417026 0.938316477952675 GO:0015662 P-type ion transporter activity 5/3038 25/18639 0.2 1.22705727452271 0.386611466417026 0.938316477952675 GO:0120515 fatty acid-CoA ligase activity 5/3038 25/18639 0.2 1.22705727452271 0.386611466417026 0.938316477952675 GO:0140358 P-type transmembrane transporter activity 5/3038 25/18639 0.2 1.22705727452271 0.386611466417026 0.938316477952675 GO:0016411 acylglycerol O-acyltransferase activity 6/3038 31/18639 0.193548387096774 1.18747478179617 0.393677646726615 0.952035529875675 GO:0016878 acid-thiol ligase activity 6/3038 31/18639 0.193548387096774 1.18747478179617 0.393677646726615 0.952035529875675 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 23/3038 132/18639 0.174242424242424 1.0690271709857 0.398350810226055 0.961610289201606 GO:0001222 transcription corepressor binding 9/3038 49/18639 0.183673469387755 1.12688933374535 0.405001610340597 0.963338590021226 GO:0060590 ATPase regulator activity 9/3038 49/18639 0.183673469387755 1.12688933374535 0.405001610340597 0.963338590021226 GO:0004065 arylsulfatase activity 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0005313 L-glutamate transmembrane transporter activity 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0005545 1-phosphatidylinositol binding 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0043176 amine binding 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0070742 C2H2 zinc finger domain binding 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0098821 BMP receptor activity 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0098847 sequence-specific single stranded DNA binding 3/3038 14/18639 0.214285714285714 1.31470422270291 0.40550332631183 0.963338590021226 GO:0016836 hydro-lyase activity 11/3038 61/18639 0.180327868852459 1.10636311637294 0.408713912852994 0.9692564095299 GO:0016835 carbon-oxygen lyase activity 14/3038 79/18639 0.177215189873418 1.0872659394505 0.411731780761178 0.970485535082075 GO:0072341 modified amino acid binding 16/3038 91/18639 0.175824175824176 1.07873166991008 0.412768873699446 0.970485535082075 GO:0070851 growth factor receptor binding 24/3038 139/18639 0.172661870503597 1.05933002117069 0.413307670448882 0.970485535082075 GO:0004722 protein serine/threonine phosphatase activity 18/3038 103/18639 0.174757281553398 1.07218596802955 0.413324372849494 0.970485535082075 GO:0004620 phospholipase activity 19/3038 109/18639 0.174311926605505 1.06945358788677 0.413468813926294 0.970485535082075 GO:0004540 RNA nuclease activity 21/3038 121/18639 0.173553719008264 1.06480176714781 0.413555083249526 0.970485535082075 GO:0001972 retinoic acid binding 4/3038 20/18639 0.2 1.22705727452271 0.415598155628159 0.973463494296575 GO:0005539 glycosaminoglycan binding 41/3038 242/18639 0.169421487603306 1.03944934412048 0.419391978852444 0.973463494296575 GO:0001637 G protein-coupled chemoattractant receptor activity 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0004950 chemokine receptor activity 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0008066 glutamate receptor activity 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0008157 protein phosphatase 1 binding 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0015145 monosaccharide transmembrane transporter activity 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0015216 purine nucleotide transmembrane transporter activity 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0034237 protein kinase A regulatory subunit binding 5/3038 26/18639 0.192307692307692 1.17986276396415 0.421328297828436 0.973463494296575 GO:0022884 macromolecule transmembrane transporter activity 6/3038 32/18639 0.1875 1.15036619486504 0.424906332875599 0.980049367094917 GO:0005501 retinoid binding 7/3038 38/18639 0.184210526315789 1.13018433179724 0.427255407488418 0.980431062839692 GO:0019840 isoprenoid binding 7/3038 38/18639 0.184210526315789 1.13018433179724 0.427255407488418 0.980431062839692 GO:0042887 amide transmembrane transporter activity 7/3038 38/18639 0.184210526315789 1.13018433179724 0.427255407488418 0.980431062839692 GO:0043014 alpha-tubulin binding 8/3038 44/18639 0.181818181818182 1.11550661320247 0.428834162724564 0.981220034111705 GO:0019887 protein kinase regulator activity 43/3038 255/18639 0.168627450980392 1.03457770204856 0.429314986333233 0.981220034111705 GO:0048029 monosaccharide binding 13/3038 74/18639 0.175675675675676 1.07782057897265 0.431381252981459 0.981220034111705 GO:0015103 inorganic anion transmembrane transporter activity 28/3038 165/18639 0.16969696969697 1.04113950565563 0.439853528253309 0.981220034111705 GO:0019208 phosphatase regulator activity 20/3038 117/18639 0.170940170940171 1.04876690130146 0.446096765984289 0.981220034111705 GO:0141003 histone H2AX kinase activity 59/3038 354/18639 0.166666666666667 1.02254772876893 0.44755582426261 0.981220034111705 GO:0000774 adenyl-nucleotide exchange factor activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0008242 omega peptidase activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0008252 nucleotidase activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0015116 sulfate transmembrane transporter activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0015929 hexosaminidase activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0017081 chloride channel regulator activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0031386 protein tag activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0140161 monocarboxylate:sodium symporter activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0141047 molecular tag activity 3/3038 15/18639 0.2 1.22705727452271 0.452112915153388 0.981220034111705 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0009975 cyclase activity 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0010314 phosphatidylinositol-5-phosphate binding 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0036122 BMP binding 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0051010 microtubule plus-end binding 4/3038 21/18639 0.19047619047619 1.16862597573592 0.454702241432502 0.981220034111705 GO:0016830 carbon-carbon lyase activity 9/3038 51/18639 0.176470588235294 1.0826975951671 0.454706951402207 0.981220034111705 GO:0005506 iron ion binding 26/3038 154/18639 0.168831168831169 1.03582756940229 0.455599282305218 0.981220034111705 GO:0001671 ATPase activator activity 5/3038 27/18639 0.185185185185185 1.13616414307659 0.455671582014303 0.981220034111705 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/3038 27/18639 0.185185185185185 1.13616414307659 0.455671582014303 0.981220034111705 GO:0016405 CoA-ligase activity 5/3038 27/18639 0.185185185185185 1.13616414307659 0.455671582014303 0.981220034111705 GO:0000217 DNA secondary structure binding 7/3038 39/18639 0.179487179487179 1.10120524636654 0.455698928967099 0.981220034111705 GO:0030296 protein tyrosine kinase activator activity 6/3038 33/18639 0.181818181818182 1.11550661320247 0.455887061308452 0.981220034111705 GO:0071889 14-3-3 protein binding 6/3038 33/18639 0.181818181818182 1.11550661320247 0.455887061308452 0.981220034111705 GO:0140311 protein sequestering activity 6/3038 33/18639 0.181818181818182 1.11550661320247 0.455887061308452 0.981220034111705 GO:0008017 microtubule binding 46/3038 276/18639 0.166666666666667 1.02254772876893 0.459292015165305 0.981220034111705 GO:1901981 phosphatidylinositol phosphate binding 31/3038 185/18639 0.167567567567568 1.0280750137893 0.463633773025562 0.981220034111705 GO:0043130 ubiquitin binding 17/3038 100/18639 0.17 1.04299868334431 0.466227910789096 0.981220034111705 GO:0031267 small GTPase binding 47/3038 283/18639 0.166077738515901 1.01893448591109 0.468846822568755 0.981220034111705 GO:0005216 monoatomic ion channel activity 74/3038 448/18639 0.165178571428571 1.01341783833349 0.469743246686555 0.981220034111705 GO:0140996 histone H3 kinase activity 59/3038 357/18639 0.165266106442577 1.01395489071205 0.475776674798389 0.981220034111705 GO:0019001 guanyl nucleotide binding 66/3038 400/18639 0.165 1.01232225148124 0.477584836600786 0.981220034111705 GO:0032561 guanyl ribonucleotide binding 66/3038 400/18639 0.165 1.01232225148124 0.477584836600786 0.981220034111705 GO:0030159 signaling receptor complex adaptor activity 9/3038 52/18639 0.173076923076923 1.06187648756773 0.479336716483752 0.981220034111705 GO:0035091 phosphatidylinositol binding 47/3038 284/18639 0.165492957746479 1.01534668842548 0.479382081810035 0.981220034111705 GO:0051020 GTPase binding 52/3038 315/18639 0.165079365079365 1.01280917897113 0.483657653483219 0.981220034111705 GO:0004177 aminopeptidase activity 7/3038 40/18639 0.175 1.07367511520737 0.483836189068372 0.981220034111705 GO:0004867 serine-type endopeptidase inhibitor activity 16/3038 95/18639 0.168421052631579 1.03331138907176 0.48578915389098 0.981220034111705 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/3038 34/18639 0.176470588235294 1.0826975951671 0.486449970224619 0.981220034111705 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6/3038 34/18639 0.176470588235294 1.0826975951671 0.486449970224619 0.981220034111705 GO:0050698 proteoglycan sulfotransferase activity 5/3038 28/18639 0.178571428571429 1.09558685225242 0.48941773610132 0.981220034111705 GO:0051019 mitogen-activated protein kinase binding 5/3038 28/18639 0.178571428571429 1.09558685225242 0.48941773610132 0.981220034111705 GO:0051393 alpha-actinin binding 5/3038 28/18639 0.178571428571429 1.09558685225242 0.48941773610132 0.981220034111705 GO:0097718 disordered domain specific binding 5/3038 28/18639 0.178571428571429 1.09558685225242 0.48941773610132 0.981220034111705 GO:0003724 RNA helicase activity 13/3038 77/18639 0.168831168831169 1.03582756940229 0.492309021383925 0.981220034111705 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/3038 22/18639 0.181818181818182 1.11550661320247 0.492889179809558 0.981220034111705 GO:0000062 fatty-acyl-CoA binding 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0005149 interleukin-1 receptor binding 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0016722 oxidoreductase activity, acting on metal ions 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0022841 potassium ion leak channel activity 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0043023 ribosomal large subunit binding 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0055102 lipase inhibitor activity 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 3/3038 16/18639 0.1875 1.15036619486504 0.497129077948977 0.981220034111705 GO:0005525 GTP binding 62/3038 378/18639 0.164021164021164 1.00631681243926 0.500155328771942 0.981220034111705 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 10/3038 59/18639 0.169491525423729 1.03987904620569 0.5004399451985 0.981220034111705 GO:0031593 polyubiquitin modification-dependent protein binding 10/3038 59/18639 0.169491525423729 1.03987904620569 0.5004399451985 0.981220034111705 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0004090 carbonyl reductase (NADPH) activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0005345 purine nucleobase transmembrane transporter activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0008140 cAMP response element binding protein binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0008190 eukaryotic initiation factor 4E binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0008401 retinoic acid 4-hydroxylase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0008519 ammonium channel activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0015203 polyamine transmembrane transporter activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0016868 intramolecular phosphotransferase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0019911 structural constituent of myelin sheath 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0031434 mitogen-activated protein kinase kinase binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0032052 bile acid binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0035256 G protein-coupled glutamate receptor binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0050815 phosphoserine residue binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0051378 serotonin binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0051880 G-quadruplex DNA binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0070097 delta-catenin binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0071723 lipopeptide binding 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0140940 histone H2A methyltransferase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0140999 histone H3K4 trimethyltransferase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0141109 transporter activator activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:1990259 histone H2AQ104 methyltransferase activity 2/3038 10/18639 0.2 1.22705727452271 0.502623109751336 0.981220034111705 GO:0005246 calcium channel regulator activity 9/3038 53/18639 0.169811320754717 1.04184108214193 0.503701098758767 0.981220034111705 GO:0005544 calcium-dependent phospholipid binding 9/3038 53/18639 0.169811320754717 1.04184108214193 0.503701098758767 0.981220034111705 GO:0008146 sulfotransferase activity 9/3038 53/18639 0.169811320754717 1.04184108214193 0.503701098758767 0.981220034111705 GO:0016251 RNA polymerase II general transcription initiation factor activity 9/3038 53/18639 0.169811320754717 1.04184108214193 0.503701098758767 0.981220034111705 GO:0035173 histone kinase activity 59/3038 360/18639 0.163888888888889 1.00550526662278 0.503949018446962 0.981220034111705 GO:0030295 protein kinase activator activity 23/3038 139/18639 0.165467625899281 1.01519127028857 0.504086312995768 0.981220034111705 GO:0004252 serine-type endopeptidase activity 29/3038 176/18639 0.164772727272727 1.01092786821473 0.506195908193317 0.983058236940426 GO:0019210 kinase inhibitor activity 15/3038 90/18639 0.166666666666667 1.02254772876893 0.506490286886901 0.983058236940426 GO:0015631 tubulin binding 63/3038 385/18639 0.163636363636364 1.00395595188222 0.508000521375743 0.984570794666369 GO:0004860 protein kinase inhibitor activity 14/3038 84/18639 0.166666666666667 1.02254772876893 0.509306325246066 0.985104490962906 GO:0019207 kinase regulator activity 47/3038 287/18639 0.163763066202091 1.0047333084071 0.510885074955024 0.985104490962906 GO:0001530 lipopolysaccharide binding 7/3038 41/18639 0.170731707317073 1.04748791727549 0.511544248341428 0.985104490962906 GO:0035250 UDP-galactosyltransferase activity 5/3038 29/18639 0.172413793103448 1.0578079952782 0.5223721100251 0.985104490962906 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 21/3038 128/18639 0.1640625 1.00657042050691 0.524100571715266 0.985104490962906 GO:0050661 NADP binding 9/3038 54/18639 0.166666666666667 1.02254772876893 0.527720306570834 0.985104490962906 GO:0003774 cytoskeletal motor activity 25/3038 153/18639 0.163398692810458 1.00249777330287 0.528657869653554 0.985104490962906 GO:0015294 solute:monoatomic cation symporter activity 19/3038 116/18639 0.163793103448276 1.00491759551429 0.529731144295992 0.985104490962906 GO:0003887 DNA-directed DNA polymerase activity 4/3038 23/18639 0.173913043478261 1.06700632567192 0.529899708771635 0.985104490962906 GO:0008171 O-methyltransferase activity 4/3038 23/18639 0.173913043478261 1.06700632567192 0.529899708771635 0.985104490962906 GO:0042171 lysophosphatidic acid acyltransferase activity 4/3038 23/18639 0.173913043478261 1.06700632567192 0.529899708771635 0.985104490962906 GO:0043274 phospholipase binding 4/3038 23/18639 0.173913043478261 1.06700632567192 0.529899708771635 0.985104490962906 GO:0071617 lysophospholipid acyltransferase activity 4/3038 23/18639 0.173913043478261 1.06700632567192 0.529899708771635 0.985104490962906 GO:0008186 ATP-dependent activity, acting on RNA 13/3038 79/18639 0.164556962025316 1.00960408663261 0.532159679781379 0.985104490962906 GO:0015370 solute:sodium symporter activity 13/3038 79/18639 0.164556962025316 1.00960408663261 0.532159679781379 0.985104490962906 GO:0038187 pattern recognition receptor activity 8/3038 48/18639 0.166666666666667 1.02254772876893 0.532810125930534 0.985104490962906 GO:0008307 structural constituent of muscle 7/3038 42/18639 0.166666666666667 1.02254772876893 0.538712431873989 0.985104490962906 GO:0019894 kinesin binding 7/3038 42/18639 0.166666666666667 1.02254772876893 0.538712431873989 0.985104490962906 GO:0015278 intracellularly gated calcium channel activity 3/3038 17/18639 0.176470588235294 1.0826975951671 0.540191769745305 0.985104490962906 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/3038 17/18639 0.176470588235294 1.0826975951671 0.540191769745305 0.985104490962906 GO:0032183 SUMO binding 3/3038 17/18639 0.176470588235294 1.0826975951671 0.540191769745305 0.985104490962906 GO:0036041 long-chain fatty acid binding 3/3038 17/18639 0.176470588235294 1.0826975951671 0.540191769745305 0.985104490962906 GO:1901567 fatty acid derivative binding 3/3038 17/18639 0.176470588235294 1.0826975951671 0.540191769745305 0.985104490962906 GO:0019209 kinase activator activity 24/3038 148/18639 0.162162162162162 0.994911303667064 0.545625373956524 0.985104490962906 GO:0016209 antioxidant activity 14/3038 86/18639 0.162790697674419 0.998767549030115 0.547326780471608 0.985104490962906 GO:0004674 protein serine/threonine kinase activity 70/3038 433/18639 0.161662817551963 0.991847681484871 0.550793079368975 0.985104490962906 GO:0008374 O-acyltransferase activity 9/3038 55/18639 0.163636363636364 1.00395595188222 0.55132128330888 0.985104490962906 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/3038 30/18639 0.166666666666667 1.02254772876893 0.554369054024479 0.985104490962906 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/3038 30/18639 0.166666666666667 1.02254772876893 0.554369054024479 0.985104490962906 GO:0015215 nucleotide transmembrane transporter activity 5/3038 30/18639 0.166666666666667 1.02254772876893 0.554369054024479 0.985104490962906 GO:0031210 phosphatidylcholine binding 5/3038 30/18639 0.166666666666667 1.02254772876893 0.554369054024479 0.985104490962906 GO:0048019 receptor antagonist activity 5/3038 30/18639 0.166666666666667 1.02254772876893 0.554369054024479 0.985104490962906 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 21/3038 130/18639 0.161538461538462 0.991084721729883 0.554912177945175 0.985104490962906 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0004016 adenylate cyclase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0005536 D-glucose binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0008046 axon guidance receptor activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0008432 JUN kinase binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0008526 phosphatidylinositol transfer activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0015205 nucleobase transmembrane transporter activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0019107 myristoyltransferase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0019864 IgG binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0032050 clathrin heavy chain binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0034056 estrogen response element binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0034511 U3 snoRNA binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0035252 UDP-xylosyltransferase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0042285 xylosyltransferase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0042608 T cell receptor binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0140031 phosphorylation-dependent protein binding 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/3038 11/18639 0.181818181818182 1.11550661320247 0.556207121248045 0.985104490962906 GO:0005261 monoatomic cation channel activity 55/3038 341/18639 0.161290322580645 0.989562318163478 0.557291596700795 0.985104490962906 GO:0008509 monoatomic anion transmembrane transporter activity 24/3038 149/18639 0.161073825503356 0.988234046595473 0.559922777467413 0.985104490962906 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/3038 43/18639 0.162790697674419 0.998767549030115 0.565242693153361 0.985104490962906 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/3038 24/18639 0.166666666666667 1.02254772876893 0.565525126242098 0.985104490962906 GO:0030552 cAMP binding 4/3038 24/18639 0.166666666666667 1.02254772876893 0.565525126242098 0.985104490962906 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/3038 24/18639 0.166666666666667 1.02254772876893 0.565525126242098 0.985104490962906 GO:0005200 structural constituent of cytoskeleton 18/3038 112/18639 0.160714285714286 0.98602816702718 0.565851669391675 0.985104490962906 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 39/3038 243/18639 0.160493827160494 0.984675590666374 0.569424965792653 0.985104490962906 GO:0019213 deacetylase activity 6/3038 37/18639 0.162162162162162 0.994911303667064 0.574201093650046 0.985104490962906 GO:0030551 cyclic nucleotide binding 6/3038 37/18639 0.162162162162162 0.994911303667064 0.574201093650046 0.985104490962906 GO:0042805 actinin binding 6/3038 37/18639 0.162162162162162 0.994911303667064 0.574201093650046 0.985104490962906 GO:0008525 phosphatidylcholine transporter activity 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0017128 phospholipid scramblase activity 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0031690 adrenergic receptor binding 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0070064 proline-rich region binding 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0070628 proteasome binding 3/3038 18/18639 0.166666666666667 1.02254772876893 0.581042050808919 0.985104490962906 GO:0140098 catalytic activity, acting on RNA 62/3038 387/18639 0.160206718346253 0.982914095870907 0.581232703381189 0.985104490962906 GO:0140597 protein carrier chaperone 30/3038 188/18639 0.159574468085106 0.979035059459611 0.581489698209078 0.985104490962906 GO:0032813 tumor necrosis factor receptor superfamily binding 8/3038 50/18639 0.16 0.98164581961817 0.582100837077724 0.985104490962906 GO:0016279 protein-lysine N-methyltransferase activity 11/3038 69/18639 0.159420289855072 0.97808913186593 0.582555455072831 0.985104490962906 GO:0004197 cysteine-type endopeptidase activity 14/3038 88/18639 0.159090909090909 0.976068286552157 0.58429639367573 0.985104490962906 GO:0005164 tumor necrosis factor receptor binding 5/3038 31/18639 0.161290322580645 0.989562318163478 0.585271247735606 0.985104490962906 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/3038 31/18639 0.161290322580645 0.989562318163478 0.585271247735606 0.985104490962906 GO:0017147 Wnt-protein binding 5/3038 31/18639 0.161290322580645 0.989562318163478 0.585271247735606 0.985104490962906 GO:0070273 phosphatidylinositol-4-phosphate binding 5/3038 31/18639 0.161290322580645 0.989562318163478 0.585271247735606 0.985104490962906 GO:0019888 protein phosphatase regulator activity 17/3038 107/18639 0.158878504672897 0.974765124620846 0.586588420703265 0.985104490962906 GO:0005507 copper ion binding 10/3038 63/18639 0.158730158730159 0.97385497977993 0.589342783869078 0.985104490962906 GO:0004676 3-phosphoinositide-dependent protein kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0004711 ribosomal protein S6 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0035175 histone H3S10 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0035979 histone H2AXS139 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0044022 histone H3S28 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0044023 histone H4S1 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0044024 histone H2AS1 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0044025 histone H2BS14 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0072354 histone H3T3 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0072371 histone H2AS121 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0072518 Rho-dependent protein serine/threonine kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0140823 histone H2BS36 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0140855 histone H3S57 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0140995 histone H2A kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0140997 histone H4 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0140998 histone H2B kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:1990244 histone H2AT120 kinase activity 39/3038 245/18639 0.159183673469388 0.976637422579302 0.591502035036922 0.985104490962906 GO:0032182 ubiquitin-like protein binding 19/3038 120/18639 0.158333333333333 0.97142034233048 0.593449111403346 0.985104490962906 GO:0051536 iron-sulfur cluster binding 12/3038 76/18639 0.157894736842105 0.968729427254773 0.59604593862901 0.985104490962906 GO:0008276 protein methyltransferase activity 15/3038 95/18639 0.157894736842105 0.968729427254773 0.596654849029057 0.985104490962906 GO:0004601 peroxidase activity 9/3038 57/18639 0.157894736842105 0.968729427254773 0.597011460865919 0.985104490962906 GO:0005251 delayed rectifier potassium channel activity 4/3038 25/18639 0.16 0.98164581961817 0.599603918589731 0.985104490962906 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/3038 25/18639 0.16 0.98164581961817 0.599603918589731 0.985104490962906 GO:0017025 TBP-class protein binding 4/3038 25/18639 0.16 0.98164581961817 0.599603918589731 0.985104490962906 GO:0004677 DNA-dependent protein kinase activity 39/3038 246/18639 0.158536585365854 0.972667351755809 0.602389378981051 0.985104490962906 GO:0140857 histone H3T45 kinase activity 39/3038 246/18639 0.158536585365854 0.972667351755809 0.602389378981051 0.985104490962906 GO:0016278 lysine N-methyltransferase activity 11/3038 70/18639 0.157142857142857 0.964116429982131 0.602840501307293 0.985104490962906 GO:0004519 endonuclease activity 20/3038 127/18639 0.15748031496063 0.966186830332844 0.604205227918545 0.985104490962906 GO:0004032 aldose reductase (NADPH) activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0004526 ribonuclease P activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0005049 nuclear export signal receptor activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0005095 GTPase inhibitor activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0005165 neurotrophin receptor binding 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0015132 prostaglandin transmembrane transporter activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0031543 peptidyl-proline dioxygenase activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0035197 siRNA binding 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0036009 protein-glutamine N-methyltransferase activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0042301 phosphate ion binding 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:1990459 transferrin receptor binding 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:1990817 poly(A) RNA polymerase activity 2/3038 12/18639 0.166666666666667 1.02254772876893 0.605543072395906 0.985104490962906 GO:0019902 phosphatase binding 30/3038 190/18639 0.157894736842105 0.968729427254773 0.606290669216721 0.985130918498099 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 13/3038 83/18639 0.156626506024096 0.960948467999715 0.608454350977546 0.986380152263611 GO:0015108 chloride transmembrane transporter activity 19/3038 121/18639 0.15702479338843 0.963392075038493 0.608831924486754 0.986380152263611 GO:0035402 histone H3T11 kinase activity 39/3038 247/18639 0.157894736842105 0.968729427254773 0.613166248546364 0.986380152263611 GO:0035403 histone H3T6 kinase activity 39/3038 247/18639 0.157894736842105 0.968729427254773 0.613166248546364 0.986380152263611 GO:0030515 snoRNA binding 5/3038 32/18639 0.15625 0.958638495720869 0.614968454191164 0.986380152263611 GO:0031369 translation initiation factor binding 5/3038 32/18639 0.15625 0.958638495720869 0.614968454191164 0.986380152263611 GO:0051540 metal cluster binding 12/3038 77/18639 0.155844155844156 0.956148525602113 0.615197369505025 0.986380152263611 GO:0042605 peptide antigen binding 7/3038 45/18639 0.155555555555556 0.954377880184332 0.616060764784408 0.986380152263611 GO:0005229 intracellularly calcium-gated chloride channel activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0016918 retinal binding 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0022840 leak channel activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0022842 narrow pore channel activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0030506 ankyrin binding 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0034987 immunoglobulin receptor binding 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0046624 sphingolipid transporter activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0141147 intracellularly calcium-gated channel activity 3/3038 19/18639 0.157894736842105 0.968729427254773 0.619508247078704 0.986380152263611 GO:0140299 molecular sensor activity 11/3038 71/18639 0.154929577464789 0.950537325334495 0.622648526510877 0.990209640153662 GO:0004679 AMP-activated protein kinase activity 39/3038 248/18639 0.157258064516129 0.964823260209391 0.623825767466868 0.990911920728622 GO:0005253 monoatomic anion channel activity 16/3038 103/18639 0.155339805825243 0.953054193804048 0.624625216190817 0.991013152189671 GO:0004529 DNA exonuclease activity 4/3038 26/18639 0.153846153846154 0.943890211171317 0.632017667819057 0.998039623156236 GO:0019865 immunoglobulin binding 4/3038 26/18639 0.153846153846154 0.943890211171317 0.632017667819057 0.998039623156236 GO:0030247 polysaccharide binding 4/3038 26/18639 0.153846153846154 0.943890211171317 0.632017667819057 0.998039623156236 GO:0120014 phospholipid transfer activity 4/3038 26/18639 0.153846153846154 0.943890211171317 0.632017667819057 0.998039623156236 GO:0035591 signaling adaptor activity 20/3038 129/18639 0.155038759689922 0.95120718955249 0.633619275421102 0.999397147531879 GO:0030291 protein serine/threonine kinase inhibitor activity 7/3038 46/18639 0.152173913043478 0.933630534962933 0.640215393317813 1 GO:0008170 N-methyltransferase activity 15/3038 98/18639 0.153061224489796 0.93907444478779 0.647146451114784 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 28/3038 181/18639 0.154696132596685 0.949105074216462 0.650148577593991 1 GO:1902936 phosphatidylinositol bisphosphate binding 17/3038 111/18639 0.153153153153153 0.939638453463338 0.650192614501055 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0004535 poly(A)-specific ribonuclease activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0004993 G protein-coupled serotonin receptor activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0005542 folic acid binding 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0031432 titin binding 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0045159 myosin II binding 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0046974 histone H3K9 methyltransferase activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0140333 glycerophospholipid flippase activity 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:1901338 catecholamine binding 2/3038 13/18639 0.153846153846154 0.943890211171317 0.650591861651755 1 GO:0034212 protein N-acetyltransferase activity 8/3038 53/18639 0.150943396226415 0.926080961903934 0.651034760935357 1 GO:0051018 protein kinase A binding 8/3038 53/18639 0.150943396226415 0.926080961903934 0.651034760935357 1 GO:0050997 quaternary ammonium group binding 6/3038 40/18639 0.15 0.920292955892034 0.653803931291182 1 GO:0001614 purinergic nucleotide receptor activity 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0016502 nucleotide receptor activity 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0030742 GTP-dependent protein binding 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0031418 L-ascorbic acid binding 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0042288 MHC class I protein binding 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0043024 ribosomal small subunit binding 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0052745 inositol phosphate phosphatase activity 3/3038 20/18639 0.15 0.920292955892034 0.655492380864094 1 GO:0019842 vitamin binding 23/3038 150/18639 0.153333333333333 0.940743910467413 0.659861835437315 1 GO:0031072 heat shock protein binding 20/3038 131/18639 0.152671755725191 0.93668494238375 0.661956762801206 1 GO:0004364 glutathione transferase activity 4/3038 27/18639 0.148148148148148 0.908931314461268 0.66268655230684 1 GO:0008395 steroid hydroxylase activity 4/3038 27/18639 0.148148148148148 0.908931314461268 0.66268655230684 1 GO:0140938 histone H3 methyltransferase activity 7/3038 47/18639 0.148936170212766 0.913766055495637 0.663464921560828 1 GO:0015020 glucuronosyltransferase activity 5/3038 34/18639 0.147058823529412 0.902247995972583 0.670432031217491 1 GO:0030332 cyclin binding 5/3038 34/18639 0.147058823529412 0.902247995972583 0.670432031217491 1 GO:0090482 vitamin transmembrane transporter activity 5/3038 34/18639 0.147058823529412 0.902247995972583 0.670432031217491 1 GO:0051213 dioxygenase activity 14/3038 93/18639 0.150537634408602 0.923591496952579 0.670513090749095 1 GO:0003925 G protein activity 8/3038 54/18639 0.148148148148148 0.908931314461268 0.672480752998752 1 GO:0051287 NAD binding 8/3038 54/18639 0.148148148148148 0.908931314461268 0.672480752998752 1 GO:0015081 sodium ion transmembrane transporter activity 25/3038 164/18639 0.152439024390244 0.93525706899597 0.675461639466653 1 GO:0042287 MHC protein binding 6/3038 41/18639 0.146341463414634 0.897846786236131 0.67819130551114 1 GO:0140318 protein transporter activity 6/3038 41/18639 0.146341463414634 0.897846786236131 0.67819130551114 1 GO:0004518 nuclease activity 32/3038 209/18639 0.15311004784689 0.939373990065234 0.679725525956464 1 GO:0046906 tetrapyrrole binding 23/3038 152/18639 0.151315789473684 0.928365701119157 0.685401869759078 1 GO:0009378 four-way junction helicase activity 7/3038 48/18639 0.145833333333333 0.894729262672811 0.685771837887951 1 GO:0043138 3'-5' DNA helicase activity 7/3038 48/18639 0.145833333333333 0.894729262672811 0.685771837887951 1 GO:0033192 calmodulin-dependent protein phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0140791 histone H2AXS140 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 12/3038 81/18639 0.148148148148148 0.908931314461268 0.687031367223194 1 GO:0005123 death receptor binding 3/3038 21/18639 0.142857142857143 0.876469481801937 0.688957404102693 1 GO:0005248 voltage-gated sodium channel activity 3/3038 21/18639 0.142857142857143 0.876469481801937 0.688957404102693 1 GO:0015125 bile acid transmembrane transporter activity 3/3038 21/18639 0.142857142857143 0.876469481801937 0.688957404102693 1 GO:0140312 cargo adaptor activity 3/3038 21/18639 0.142857142857143 0.876469481801937 0.688957404102693 1 GO:0004705 JUN kinase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0008331 high voltage-gated calcium channel activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0008392 arachidonate epoxygenase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0008474 palmitoyl-(protein) hydrolase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0008494 translation activator activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0015926 glucosidase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0016530 metallochaperone activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0019763 immunoglobulin receptor activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0034236 protein kinase A catalytic subunit binding 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0042813 Wnt receptor activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0098599 palmitoyl hydrolase activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:1901474 azole transmembrane transporter activity 2/3038 14/18639 0.142857142857143 0.876469481801937 0.691439950875076 1 GO:0046875 ephrin receptor binding 4/3038 28/18639 0.142857142857143 0.876469481801937 0.691564688341094 1 GO:0003714 transcription corepressor activity 31/3038 204/18639 0.151960784313725 0.932322929171669 0.694514721378209 1 GO:0000175 3'-5'-RNA exonuclease activity 5/3038 35/18639 0.142857142857143 0.876469481801937 0.696096894191431 1 GO:0034061 DNA polymerase activity 5/3038 35/18639 0.142857142857143 0.876469481801937 0.696096894191431 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 12/3038 82/18639 0.146341463414634 0.897846786236131 0.703682374576848 1 GO:0033549 MAP kinase phosphatase activity 12/3038 82/18639 0.146341463414634 0.897846786236131 0.703682374576848 1 GO:0030170 pyridoxal phosphate binding 8/3038 56/18639 0.142857142857143 0.876469481801937 0.712881253009817 1 GO:0008528 G protein-coupled peptide receptor activity 18/3038 122/18639 0.147540983606557 0.905206186123312 0.715008696102732 1 GO:0050321 tau-protein kinase activity 3/3038 22/18639 0.136363636363636 0.836629959901849 0.719915544780557 1 GO:0140035 ubiquitin-like protein reader activity 3/3038 22/18639 0.136363636363636 0.836629959901849 0.719915544780557 1 GO:0004033 aldo-keto reductase (NADPH) activity 5/3038 36/18639 0.138888888888889 0.852123107307439 0.720349336170355 1 GO:0004190 aspartic-type endopeptidase activity 5/3038 36/18639 0.138888888888889 0.852123107307439 0.720349336170355 1 GO:0055106 ubiquitin-protein transferase regulator activity 5/3038 36/18639 0.138888888888889 0.852123107307439 0.720349336170355 1 GO:0005245 voltage-gated calcium channel activity 6/3038 43/18639 0.13953488372093 0.856086470597241 0.723523474931309 1 GO:0099094 ligand-gated monoatomic cation channel activity 20/3038 136/18639 0.147058823529412 0.902247995972583 0.727452322671174 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0015250 water channel activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0030553 cGMP binding 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0034483 heparan sulfate sulfotransferase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0047372 monoacylglycerol lipase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0050780 dopamine receptor binding 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0120283 protein serine/threonine kinase binding 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0141050 histone H3K deacetylase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0141051 histone H4K deacetylase activity 2/3038 15/18639 0.133333333333333 0.818038183015142 0.728259494832258 1 GO:0106310 protein serine kinase activity 55/3038 361/18639 0.152354570637119 0.934738921035307 0.730684621627224 1 GO:0070279 vitamin B6 binding 8/3038 57/18639 0.140350877192982 0.861092824226465 0.731798770094536 1 GO:0017018 myosin phosphatase activity 12/3038 84/18639 0.142857142857143 0.876469481801937 0.735305424631736 1 GO:0004536 DNA nuclease activity 9/3038 64/18639 0.140625 0.862774646148782 0.736343674664745 1 GO:0070001 aspartic-type peptidase activity 5/3038 37/18639 0.135135135135135 0.829092753055887 0.743184999064153 1 GO:0033612 receptor serine/threonine kinase binding 4/3038 30/18639 0.133333333333333 0.818038183015142 0.743907261925063 1 GO:0051721 protein phosphatase 2A binding 4/3038 30/18639 0.133333333333333 0.818038183015142 0.743907261925063 1 GO:0098918 structural constituent of synapse 4/3038 30/18639 0.133333333333333 0.818038183015142 0.743907261925063 1 GO:0001046 core promoter sequence-specific DNA binding 6/3038 44/18639 0.136363636363636 0.836629959901849 0.744440384800936 1 GO:0001223 transcription coactivator binding 6/3038 44/18639 0.136363636363636 0.836629959901849 0.744440384800936 1 GO:0019903 protein phosphatase binding 21/3038 144/18639 0.145833333333333 0.894729262672811 0.74499556263512 1 GO:0005212 structural constituent of eye lens 3/3038 23/18639 0.130434782608696 0.800254744253943 0.748417920181895 1 GO:0017134 fibroblast growth factor binding 3/3038 23/18639 0.130434782608696 0.800254744253943 0.748417920181895 1 GO:0099186 structural constituent of postsynapse 3/3038 23/18639 0.130434782608696 0.800254744253943 0.748417920181895 1 GO:0140103 catalytic activity, acting on a glycoprotein 3/3038 23/18639 0.130434782608696 0.800254744253943 0.748417920181895 1 GO:0140104 molecular carrier activity 37/3038 249/18639 0.14859437751004 0.911669059384344 0.756779965821356 1 GO:0046332 SMAD binding 11/3038 79/18639 0.139240506329114 0.854280380996825 0.760757965189705 1 GO:0003688 DNA replication origin binding 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0004707 MAP kinase activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0005521 lamin binding 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0008296 3'-5'-DNA exonuclease activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0008391 arachidonate monooxygenase activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0015378 sodium:chloride symporter activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0015562 efflux transmembrane transporter activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0019841 retinol binding 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0030275 LRR domain binding 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0140327 flippase activity 2/3038 16/18639 0.125 0.766910796576695 0.761278125815585 1 GO:0051539 4 iron, 4 sulfur cluster binding 6/3038 45/18639 0.133333333333333 0.818038183015142 0.764191095572709 1 GO:0000146 microfilament motor activity 5/3038 38/18639 0.131578947368421 0.807274522712311 0.76461402773973 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/3038 38/18639 0.131578947368421 0.807274522712311 0.76461402773973 1 GO:0042162 telomeric DNA binding 5/3038 38/18639 0.131578947368421 0.807274522712311 0.76461402773973 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 12/3038 86/18639 0.13953488372093 0.856086470597241 0.764635041983647 1 GO:0016887 ATP hydrolysis activity 63/3038 417/18639 0.151079136690647 0.926913768524351 0.766213897056066 1 GO:0070888 E-box binding 8/3038 59/18639 0.135593220338983 0.831903236964551 0.76702764329894 1 GO:0015295 solute:proton symporter activity 3/3038 24/18639 0.125 0.766910796576695 0.774545462173294 1 GO:0048027 mRNA 5'-UTR binding 3/3038 24/18639 0.125 0.766910796576695 0.774545462173294 1 GO:0015079 potassium ion transmembrane transporter activity 23/3038 160/18639 0.14375 0.881947416063199 0.776224279710022 1 GO:0140296 general transcription initiation factor binding 7/3038 53/18639 0.132075471698113 0.810320841665942 0.782540933317496 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 6/3038 46/18639 0.130434782608696 0.800254744253943 0.782787450910943 1 GO:0001098 basal transcription machinery binding 8/3038 60/18639 0.133333333333333 0.818038183015142 0.783340994473144 1 GO:0001099 basal RNA polymerase II transcription machinery binding 8/3038 60/18639 0.133333333333333 0.818038183015142 0.783340994473144 1 GO:0003697 single-stranded DNA binding 17/3038 121/18639 0.140495867768595 0.861982382929178 0.783921241922408 1 GO:0001653 peptide receptor activity 18/3038 128/18639 0.140625 0.862774646148782 0.787646035028842 1 GO:0140142 nucleocytoplasmic carrier activity 4/3038 32/18639 0.125 0.766910796576695 0.789186099294788 1 GO:0009881 photoreceptor activity 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0016805 dipeptidase activity 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0031489 myosin V binding 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0045125 bioactive lipid receptor activity 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0045236 CXCR chemokine receptor binding 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0046965 nuclear retinoid X receptor binding 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0070403 NAD+ binding 2/3038 17/18639 0.117647058823529 0.721798396778066 0.790756306624955 1 GO:0020037 heme binding 20/3038 142/18639 0.140845070422535 0.864124841213178 0.794908124026107 1 GO:0001848 complement binding 3/3038 25/18639 0.12 0.736234364713627 0.798401127207417 1 GO:0008483 transaminase activity 3/3038 25/18639 0.12 0.736234364713627 0.798401127207417 1 GO:0017056 structural constituent of nuclear pore 3/3038 25/18639 0.12 0.736234364713627 0.798401127207417 1 GO:0005548 phospholipid transporter activity 9/3038 68/18639 0.132352941176471 0.812023196375324 0.799469196973026 1 GO:0030145 manganese ion binding 9/3038 68/18639 0.132352941176471 0.812023196375324 0.799469196973026 1 GO:0140223 general transcription initiation factor activity 9/3038 68/18639 0.132352941176471 0.812023196375324 0.799469196973026 1 GO:0061733 protein-lysine-acetyltransferase activity 6/3038 47/18639 0.127659574468085 0.783228047567689 0.800249284474375 1 GO:0061749 forked DNA-dependent helicase activity 6/3038 47/18639 0.127659574468085 0.783228047567689 0.800249284474375 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 6/3038 47/18639 0.127659574468085 0.783228047567689 0.800249284474375 1 GO:0044183 protein folding chaperone 10/3038 75/18639 0.133333333333333 0.818038183015142 0.800708249001006 1 GO:0002020 protease binding 19/3038 136/18639 0.139705882352941 0.857135596173954 0.801679238952219 1 GO:0004532 RNA exonuclease activity 5/3038 40/18639 0.125 0.766910796576695 0.803352488204138 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/3038 40/18639 0.125 0.766910796576695 0.803352488204138 1 GO:0140662 ATP-dependent protein folding chaperone 5/3038 40/18639 0.125 0.766910796576695 0.803352488204138 1 GO:0016407 acetyltransferase activity 13/3038 96/18639 0.135416666666667 0.830820029624753 0.806433985736881 1 GO:0016922 nuclear receptor binding 19/3038 137/18639 0.138686131386861 0.850879131968304 0.811680943605802 1 GO:0008080 N-acetyltransferase activity 9/3038 69/18639 0.130434782608696 0.800254744253943 0.81334575750307 1 GO:1990782 protein tyrosine kinase binding 16/3038 117/18639 0.136752136752137 0.839013521041171 0.813626452001423 1 GO:0005254 chloride channel activity 11/3038 83/18639 0.132530120481928 0.813110242153605 0.814967464878833 1 GO:0036121 double-stranded DNA helicase activity 6/3038 48/18639 0.125 0.766910796576695 0.816603205415293 1 GO:0000900 mRNA regulatory element binding translation repressor activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0005372 water transmembrane transporter activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0008308 voltage-gated monoatomic anion channel activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0008409 5'-3' exonuclease activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0015373 monoatomic anion:sodium symporter activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0035615 clathrin adaptor activity 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:1901611 phosphatidylglycerol binding 2/3038 18/18639 0.111111111111111 0.681698485845951 0.816970588601959 1 GO:0005112 Notch binding 3/3038 26/18639 0.115384615384615 0.707917658378488 0.82010331756242 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/3038 26/18639 0.115384615384615 0.707917658378488 0.82010331756242 1 GO:0008143 poly(A) binding 3/3038 26/18639 0.115384615384615 0.707917658378488 0.82010331756242 1 GO:0050681 nuclear androgen receptor binding 3/3038 26/18639 0.115384615384615 0.707917658378488 0.82010331756242 1 GO:0052742 phosphatidylinositol kinase activity 3/3038 26/18639 0.115384615384615 0.707917658378488 0.82010331756242 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 51/3038 349/18639 0.146131805157593 0.896560472788801 0.824382012841785 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/3038 34/18639 0.117647058823529 0.721798396778066 0.827813302025059 1 GO:0016831 carboxy-lyase activity 4/3038 34/18639 0.117647058823529 0.721798396778066 0.827813302025059 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 12/3038 91/18639 0.131868131868132 0.809048752432558 0.827865463020236 1 GO:0019212 phosphatase inhibitor activity 7/3038 56/18639 0.125 0.766910796576695 0.828864169534172 1 GO:0005249 voltage-gated potassium channel activity 13/3038 98/18639 0.13265306122449 0.813864518816085 0.829056568895068 1 GO:0140101 catalytic activity, acting on a tRNA 19/3038 139/18639 0.136690647482014 0.838636266760127 0.830589522739127 1 GO:0000182 rDNA binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0001094 TFIID-class transcription factor complex binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0003796 lysozyme activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0004935 adrenergic receptor activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0005337 nucleoside transmembrane transporter activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0005381 iron ion transmembrane transporter activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0005522 profilin binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0015187 glycine transmembrane transporter activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0015279 store-operated calcium channel activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0019531 oxalate transmembrane transporter activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0032395 MHC class II receptor activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0033204 ribonuclease P RNA binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0035374 chondroitin sulfate binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0043208 glycosphingolipid binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0043295 glutathione binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0045322 unmethylated CpG binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0050308 sugar-phosphatase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0051864 histone H3K36 demethylase activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0140135 mechanosensitive monoatomic cation channel activity 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:1905394 retromer complex binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:1990763 arrestin family protein binding 1/3038 10/18639 0.1 0.613528637261356 0.831308177308858 1 GO:0031492 nucleosomal DNA binding 5/3038 42/18639 0.119047619047619 0.730391234834948 0.836857364361161 1 GO:0042056 chemoattractant activity 5/3038 42/18639 0.119047619047619 0.730391234834948 0.836857364361161 1 GO:0051879 Hsp90 protein binding 5/3038 42/18639 0.119047619047619 0.730391234834948 0.836857364361161 1 GO:0005104 fibroblast growth factor receptor binding 3/3038 27/18639 0.111111111111111 0.681698485845951 0.839780413219368 1 GO:0008266 poly(U) RNA binding 3/3038 27/18639 0.111111111111111 0.681698485845951 0.839780413219368 1 GO:0008301 DNA binding, bending 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0008381 mechanosensitive monoatomic ion channel activity 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0042834 peptidoglycan binding 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0046527 glucosyltransferase activity 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0070003 threonine-type peptidase activity 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0097001 ceramide binding 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0099589 serotonin receptor activity 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:1990380 K48-linked deubiquitinase activity 2/3038 19/18639 0.105263157894737 0.645819618169849 0.840201452310578 1 GO:0003712 transcription coregulator activity 73/3038 495/18639 0.147474747474747 0.904799808486444 0.843634131128334 1 GO:0042826 histone deacetylase binding 17/3038 127/18639 0.133858267716535 0.821258805782918 0.844763984227912 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/3038 43/18639 0.116279069767442 0.713405392164368 0.851769718233511 1 GO:0051082 unfolded protein binding 16/3038 121/18639 0.132231404958678 0.811277536874521 0.852289975650652 1 GO:0017116 single-stranded DNA helicase activity 7/3038 58/18639 0.120689655172414 0.74046559669474 0.855163836927873 1 GO:0005242 inward rectifier potassium channel activity 3/3038 28/18639 0.107142857142857 0.657352111351453 0.857566300204761 1 GO:0036408 histone H3K14 acetyltransferase activity 3/3038 28/18639 0.107142857142857 0.657352111351453 0.857566300204761 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0001851 complement component C3b binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0002162 dystroglycan binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0008503 benzodiazepine receptor activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0015173 aromatic amino acid transmembrane transporter activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0016594 glycine binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0019203 carbohydrate phosphatase activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0019215 intermediate filament binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0043522 leucine zipper domain binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0047676 arachidonate-CoA ligase activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0048407 platelet-derived growth factor binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0050786 RAGE receptor binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0070697 activin receptor binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:1900750 oligopeptide binding 1/3038 11/18639 0.0909090909090909 0.557753306601233 0.858818282914939 1 GO:0019787 ubiquitin-like protein transferase activity 70/3038 479/18639 0.146137787056367 0.896597173450834 0.859229680058112 1 GO:0005048 signal sequence binding 6/3038 51/18639 0.117647058823529 0.721798396778066 0.859361781696317 1 GO:0000993 RNA polymerase II complex binding 4/3038 36/18639 0.111111111111111 0.681698485845951 0.860366421474682 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/3038 36/18639 0.111111111111111 0.681698485845951 0.860366421474682 1 GO:0061608 nuclear import signal receptor activity 2/3038 20/18639 0.1 0.613528637261356 0.860724682471298 1 GO:0140939 histone H4 methyltransferase activity 2/3038 20/18639 0.1 0.613528637261356 0.860724682471298 1 GO:0022843 voltage-gated monoatomic cation channel activity 19/3038 143/18639 0.132867132867133 0.815177909647956 0.864142356567329 1 GO:0045309 protein phosphorylated amino acid binding 7/3038 59/18639 0.11864406779661 0.727915332343982 0.867028324531768 1 GO:0140713 histone chaperone activity 22/3038 164/18639 0.134146341463415 0.823026220716453 0.868141538179641 1 GO:0003684 damaged DNA binding 9/3038 74/18639 0.121621621621622 0.746183477750298 0.871978851246496 1 GO:0000510 H3-H4 histone complex chaperone activity 20/3038 151/18639 0.132450331125828 0.812620711604445 0.872729787665691 1 GO:0140584 chromatin extrusion motor activity 20/3038 151/18639 0.132450331125828 0.812620711604445 0.872729787665691 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 20/3038 151/18639 0.132450331125828 0.812620711604445 0.872729787665691 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 20/3038 151/18639 0.132450331125828 0.812620711604445 0.872729787665691 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/3038 29/18639 0.103448275862069 0.63468479716692 0.873596777050889 1 GO:0010484 histone H3 acetyltransferase activity 3/3038 29/18639 0.103448275862069 0.63468479716692 0.873596777050889 1 GO:0097472 cyclin-dependent protein kinase activity 3/3038 29/18639 0.103448275862069 0.63468479716692 0.873596777050889 1 GO:0140658 ATP-dependent chromatin remodeler activity 21/3038 158/18639 0.132911392405063 0.815449454587878 0.873863586106827 1 GO:0016755 aminoacyltransferase activity 72/3038 496/18639 0.145161290322581 0.89060608634713 0.87618339430796 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/3038 60/18639 0.116666666666667 0.715783410138249 0.878081368124416 1 GO:0140303 intramembrane lipid transporter activity 5/3038 45/18639 0.111111111111111 0.681698485845951 0.878197238388117 1 GO:0001846 opsonin binding 2/3038 21/18639 0.0952380952380952 0.584312987867958 0.878805448615362 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/3038 21/18639 0.0952380952380952 0.584312987867958 0.878805448615362 1 GO:0019200 carbohydrate kinase activity 2/3038 21/18639 0.0952380952380952 0.584312987867958 0.878805448615362 1 GO:0035613 RNA stem-loop binding 2/3038 21/18639 0.0952380952380952 0.584312987867958 0.878805448615362 1 GO:1904047 S-adenosyl-L-methionine binding 2/3038 21/18639 0.0952380952380952 0.584312987867958 0.878805448615362 1 GO:0015276 ligand-gated monoatomic ion channel activity 25/3038 186/18639 0.134408602150538 0.824635265136231 0.878932954448163 1 GO:0015616 DNA translocase activity 20/3038 152/18639 0.131578947368421 0.807274522712311 0.879734932502724 1 GO:0140674 ATP-dependent histone chaperone activity 20/3038 152/18639 0.131578947368421 0.807274522712311 0.879734932502724 1 GO:0003720 telomerase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0004000 adenosine deaminase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0004126 cytidine deaminase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0004859 phospholipase inhibitor activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0005078 MAP-kinase scaffold activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0005247 voltage-gated chloride channel activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0005436 sodium:phosphate symporter activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0016273 arginine N-methyltransferase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0016274 protein-arginine N-methyltransferase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0016423 tRNA (guanine) methyltransferase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0016840 carbon-nitrogen lyase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0035251 UDP-glucosyltransferase activity 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0070679 inositol 1,4,5 trisphosphate binding 1/3038 12/18639 0.0833333333333333 0.511273864384463 0.881843302053033 1 GO:0061775 cohesin loader activity 20/3038 153/18639 0.130718954248366 0.801998218642296 0.886433853627782 1 GO:0003689 DNA clamp loader activity 21/3038 160/18639 0.13125 0.80525633640553 0.887203350354846 1 GO:0008187 poly-pyrimidine tract binding 3/3038 30/18639 0.1 0.613528637261356 0.888006723175981 1 GO:0016769 transferase activity, transferring nitrogenous groups 3/3038 30/18639 0.1 0.613528637261356 0.888006723175981 1 GO:0043995 histone H4K5 acetyltransferase activity 3/3038 30/18639 0.1 0.613528637261356 0.888006723175981 1 GO:0043996 histone H4K8 acetyltransferase activity 3/3038 30/18639 0.1 0.613528637261356 0.888006723175981 1 GO:0043997 histone H4K12 acetyltransferase activity 3/3038 30/18639 0.1 0.613528637261356 0.888006723175981 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/3038 46/18639 0.108695652173913 0.666878953544952 0.889832578324357 1 GO:0022834 ligand-gated channel activity 25/3038 188/18639 0.132978723404255 0.815862549549676 0.890957032304658 1 GO:0140463 chromatin-protein adaptor activity 6/3038 54/18639 0.111111111111111 0.681698485845951 0.893533895753094 1 GO:0004407 histone deacetylase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0008970 phospholipase A1 activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0015377 chloride:monoatomic cation symporter activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0032931 histone H3K56 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0033558 protein lysine deacetylase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0043992 histone H3K9 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0043993 histone H3K18 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0043994 histone H3K23 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0043999 histone H2AK5 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044012 histone H2AK9 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044014 histone H2BK5 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044015 histone H2BK12 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044016 histone H3K4 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044017 histone H3K27 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0044018 histone H3K36 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0046972 histone H4K16 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0140908 histone H3K122 acetyltransferase activity 2/3038 22/18639 0.0909090909090909 0.557753306601233 0.894694438998842 1 GO:0004842 ubiquitin-protein transferase activity 64/3038 449/18639 0.142538975501114 0.87451743395828 0.896371904154211 1 GO:0004527 exonuclease activity 10/3038 84/18639 0.119047619047619 0.730391234834948 0.896847403435086 1 GO:0051087 protein-folding chaperone binding 17/3038 134/18639 0.126865671641791 0.778357226376347 0.89826909856645 1 GO:0047499 calcium-independent phospholipase A2 activity 3/3038 31/18639 0.0967741935483871 0.593737390898087 0.900927919195889 1 GO:0003964 RNA-directed DNA polymerase activity 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0032396 inhibitory MHC class I receptor activity 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0051011 microtubule minus-end binding 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0071837 HMG box domain binding 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0089720 caspase binding 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0097157 pre-mRNA intronic binding 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0140666 annealing activity 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0140852 histone ubiquitin ligase activity 1/3038 13/18639 0.0769230769230769 0.471945105585659 0.901114255419807 1 GO:0044013 histone H2B acetyltransferase activity 2/3038 23/18639 0.0869565217391304 0.533503162835962 0.908625536029028 1 GO:0051219 phosphoprotein binding 11/3038 93/18639 0.118279569892473 0.725679033319884 0.909778921048977 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/3038 40/18639 0.1 0.613528637261356 0.90991665161635 1 GO:0008188 neuropeptide receptor activity 5/3038 48/18639 0.104166666666667 0.639092330480579 0.910252378343681 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/3038 56/18639 0.107142857142857 0.657352111351453 0.912151532492663 1 GO:0001221 transcription coregulator binding 14/3038 115/18639 0.121739130434783 0.746904427970347 0.912199106870028 1 GO:0101005 deubiquitinase activity 14/3038 115/18639 0.121739130434783 0.746904427970347 0.912199106870028 1 GO:0043425 bHLH transcription factor binding 3/3038 32/18639 0.09375 0.575183097432521 0.912487417806348 1 GO:0070717 poly-purine tract binding 3/3038 32/18639 0.09375 0.575183097432521 0.912487417806348 1 GO:0016410 N-acyltransferase activity 11/3038 94/18639 0.117021276595745 0.717959043603715 0.916493500488617 1 GO:0140297 DNA-binding transcription factor binding 69/3038 488/18639 0.141393442622951 0.867489261701508 0.916806359555972 1 GO:0032454 histone H3K9 demethylase activity 1/3038 14/18639 0.0714285714285714 0.438234740900969 0.917243048077094 1 GO:0046030 inositol trisphosphate phosphatase activity 1/3038 14/18639 0.0714285714285714 0.438234740900969 0.917243048077094 1 GO:0061783 peptidoglycan muralytic activity 1/3038 14/18639 0.0714285714285714 0.438234740900969 0.917243048077094 1 GO:1901612 cardiolipin binding 1/3038 14/18639 0.0714285714285714 0.438234740900969 0.917243048077094 1 GO:1990825 sequence-specific mRNA binding 1/3038 14/18639 0.0714285714285714 0.438234740900969 0.917243048077094 1 GO:0016504 peptidase activator activity 6/3038 57/18639 0.105263157894737 0.645819618169849 0.920351321555832 1 GO:0005244 voltage-gated monoatomic ion channel activity 22/3038 173/18639 0.127167630057803 0.780209827731204 0.920697124068726 1 GO:0005540 hyaluronic acid binding 2/3038 24/18639 0.0833333333333333 0.511273864384463 0.920814633652276 1 GO:0043998 histone H2A acetyltransferase activity 2/3038 24/18639 0.0833333333333333 0.511273864384463 0.920814633652276 1 GO:0019843 rRNA binding 7/3038 65/18639 0.107692307692308 0.660723147819922 0.922458648239579 1 GO:0003713 transcription coactivator activity 34/3038 256/18639 0.1328125 0.814842721362739 0.922503731463937 1 GO:0019239 deaminase activity 3/3038 33/18639 0.0909090909090909 0.557753306601233 0.922806373746919 1 GO:0042923 neuropeptide binding 3/3038 33/18639 0.0909090909090909 0.557753306601233 0.922806373746919 1 GO:0061659 ubiquitin-like protein ligase activity 51/3038 372/18639 0.137096774193548 0.841127970438956 0.927160376369183 1 GO:0008408 3'-5' exonuclease activity 6/3038 58/18639 0.103448275862069 0.63468479716692 0.92787295439752 1 GO:0004520 DNA endonuclease activity 4/3038 42/18639 0.0952380952380952 0.584312987867958 0.928263114184522 1 GO:0043175 RNA polymerase core enzyme binding 4/3038 42/18639 0.0952380952380952 0.584312987867958 0.928263114184522 1 GO:0022832 voltage-gated channel activity 22/3038 175/18639 0.125714285714286 0.771293143985705 0.929659290346761 1 GO:0004089 carbonate dehydratase activity 1/3038 15/18639 0.0666666666666667 0.409019091507571 0.930741873308867 1 GO:0004559 alpha-mannosidase activity 1/3038 15/18639 0.0666666666666667 0.409019091507571 0.930741873308867 1 GO:0008020 G protein-coupled photoreceptor activity 1/3038 15/18639 0.0666666666666667 0.409019091507571 0.930741873308867 1 GO:0010181 FMN binding 1/3038 15/18639 0.0666666666666667 0.409019091507571 0.930741873308867 1 GO:0042809 nuclear vitamin D receptor binding 1/3038 15/18639 0.0666666666666667 0.409019091507571 0.930741873308867 1 GO:0008139 nuclear localization sequence binding 2/3038 25/18639 0.08 0.490822909809085 0.931459286386612 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/3038 25/18639 0.08 0.490822909809085 0.931459286386612 1 GO:0042974 nuclear retinoic acid receptor binding 2/3038 25/18639 0.08 0.490822909809085 0.931459286386612 1 GO:0003678 DNA helicase activity 8/3038 74/18639 0.108108108108108 0.663274202444709 0.931526048847194 1 GO:0031491 nucleosome binding 8/3038 74/18639 0.108108108108108 0.663274202444709 0.931526048847194 1 GO:0004386 helicase activity 19/3038 155/18639 0.12258064516129 0.752067361804243 0.934609485507204 1 GO:0070063 RNA polymerase binding 6/3038 59/18639 0.101694915254237 0.623927427723413 0.934761025703077 1 GO:0004623 phospholipase A2 activity 3/3038 35/18639 0.0857142857142857 0.525881689081162 0.940173340790189 1 GO:0010485 histone H4 acetyltransferase activity 3/3038 35/18639 0.0857142857142857 0.525881689081162 0.940173340790189 1 GO:0140566 histone reader activity 3/3038 35/18639 0.0857142857142857 0.525881689081162 0.940173340790189 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/3038 60/18639 0.1 0.613528637261356 0.941058765434039 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/3038 16/18639 0.0625 0.383455398288348 0.942039456475086 1 GO:0004708 MAP kinase kinase activity 1/3038 16/18639 0.0625 0.383455398288348 0.942039456475086 1 GO:0015923 mannosidase activity 1/3038 16/18639 0.0625 0.383455398288348 0.942039456475086 1 GO:0140328 floppase activity 1/3038 16/18639 0.0625 0.383455398288348 0.942039456475086 1 GO:0004864 protein phosphatase inhibitor activity 5/3038 53/18639 0.0943396226415094 0.578800601189959 0.94743467879626 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/3038 53/18639 0.0943396226415094 0.578800601189959 0.94743467879626 1 GO:0008234 cysteine-type peptidase activity 23/3038 187/18639 0.122994652406417 0.754607414813433 0.948137105945575 1 GO:0061630 ubiquitin protein ligase activity 47/3038 353/18639 0.13314447592068 0.816879488704922 0.948814651157203 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/3038 27/18639 0.0740740740740741 0.454465657230634 0.948815633434168 1 GO:0004843 cysteine-type deubiquitinase activity 12/3038 108/18639 0.111111111111111 0.681698485845951 0.950579054047315 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:0016018 cyclosporin A binding 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:0070402 NADPH binding 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:1990226 histone methyltransferase binding 1/3038 17/18639 0.0588235294117647 0.360899198389033 0.95149465334072 1 GO:0030280 structural constituent of skin epidermis 3/3038 37/18639 0.0810810810810811 0.497455651833532 0.953857187481214 1 GO:0046625 sphingolipid binding 2/3038 28/18639 0.0714285714285714 0.438234740900969 0.955834812913354 1 GO:0046966 nuclear thyroid hormone receptor binding 2/3038 28/18639 0.0714285714285714 0.438234740900969 0.955834812913354 1 GO:0141052 histone H3 demethylase activity 2/3038 28/18639 0.0714285714285714 0.438234740900969 0.955834812913354 1 GO:0003746 translation elongation factor activity 1/3038 18/18639 0.0555555555555556 0.340849242922976 0.95940783361947 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/3038 18/18639 0.0555555555555556 0.340849242922976 0.95940783361947 1 GO:0032393 MHC class I receptor activity 1/3038 18/18639 0.0555555555555556 0.340849242922976 0.95940783361947 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/3038 47/18639 0.0851063829787234 0.522152031711792 0.960275513108701 1 GO:0106222 lncRNA binding 2/3038 29/18639 0.0689655172413793 0.42312319811128 0.961926519273536 1 GO:0019783 ubiquitin-like protein peptidase activity 14/3038 127/18639 0.110236220472441 0.676330781232991 0.964246861472279 1 GO:0030971 receptor tyrosine kinase binding 8/3038 81/18639 0.0987654320987654 0.605954209640846 0.964504438831008 1 GO:0140693 molecular condensate scaffold activity 4/3038 48/18639 0.0833333333333333 0.511273864384463 0.964823070814612 1 GO:0003727 single-stranded RNA binding 9/3038 89/18639 0.101123595505618 0.620422217455304 0.964878998865931 1 GO:0022821 solute:potassium antiporter activity 1/3038 19/18639 0.0526315789473684 0.322909809084924 0.966030410358853 1 GO:0140036 ubiquitin-modified protein reader activity 1/3038 19/18639 0.0526315789473684 0.322909809084924 0.966030410358853 1 GO:0032452 histone demethylase activity 2/3038 30/18639 0.0666666666666667 0.409019091507571 0.967206504709076 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/3038 20/18639 0.05 0.306764318630678 0.971572817089777 1 GO:0016505 peptidase activator activity involved in apoptotic process 1/3038 20/18639 0.05 0.306764318630678 0.971572817089777 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/3038 20/18639 0.05 0.306764318630678 0.971572817089777 1 GO:0005184 neuropeptide hormone activity 2/3038 31/18639 0.0645161290322581 0.395824927265391 0.97177744164102 1 GO:0140457 protein demethylase activity 2/3038 31/18639 0.0645161290322581 0.395824927265391 0.97177744164102 1 GO:0008227 G protein-coupled amine receptor activity 3/3038 41/18639 0.0731707317073171 0.448923393118065 0.972902564549343 1 GO:0042169 SH2 domain binding 3/3038 41/18639 0.0731707317073171 0.448923393118065 0.972902564549343 1 GO:0022836 gated channel activity 40/3038 318/18639 0.125786163522013 0.771734134919945 0.973642099804356 1 GO:0047498 calcium-dependent phospholipase A2 activity 2/3038 32/18639 0.0625 0.383455398288348 0.975730109896664 1 GO:0160041 neuropeptide activity 2/3038 32/18639 0.0625 0.383455398288348 0.975730109896664 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/3038 21/18639 0.0476190476190476 0.292156493933979 0.976211185513498 1 GO:0070182 DNA polymerase binding 1/3038 21/18639 0.0476190476190476 0.292156493933979 0.976211185513498 1 GO:0004402 histone acetyltransferase activity 3/3038 42/18639 0.0714285714285714 0.438234740900969 0.97633636842356 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/3038 69/18639 0.0869565217391304 0.533503162835962 0.977441998937493 1 GO:0005243 gap junction channel activity 1/3038 22/18639 0.0454545454545455 0.278876653300616 0.980092935347529 1 GO:0016881 acid-amino acid ligase activity 1/3038 22/18639 0.0454545454545455 0.278876653300616 0.980092935347529 1 GO:0031683 G-protein beta/gamma-subunit complex binding 1/3038 22/18639 0.0454545454545455 0.278876653300616 0.980092935347529 1 GO:0140517 protein-RNA adaptor activity 1/3038 22/18639 0.0454545454545455 0.278876653300616 0.980092935347529 1 GO:0008094 ATP-dependent activity, acting on DNA 24/3038 210/18639 0.114285714285714 0.70117558544155 0.981757203802471 1 GO:0019825 oxygen binding 2/3038 34/18639 0.0588235294117647 0.360899198389033 0.982091125288938 1 GO:0070577 lysine-acetylated histone binding 1/3038 23/18639 0.0434782608695652 0.266751581417981 0.98334145349837 1 GO:0022824 transmitter-gated monoatomic ion channel activity 5/3038 63/18639 0.0793650793650794 0.486927489889965 0.983369668501336 1 GO:0022835 transmitter-gated channel activity 5/3038 63/18639 0.0793650793650794 0.486927489889965 0.983369668501336 1 GO:0030594 neurotransmitter receptor activity 9/3038 97/18639 0.0927835051546392 0.569253374778578 0.983792047131788 1 GO:0046982 protein heterodimerization activity 46/3038 369/18639 0.124661246612466 0.764832447534482 0.983965506347746 1 GO:0140097 catalytic activity, acting on DNA 41/3038 336/18639 0.12202380952381 0.748651015705821 0.985809058754084 1 GO:0004622 lysophospholipase activity 1/3038 24/18639 0.0416666666666667 0.255636932192232 0.986060010882983 1 GO:0140033 acetylation-dependent protein binding 1/3038 24/18639 0.0416666666666667 0.255636932192232 0.986060010882983 1 GO:0140612 DNA damage sensor activity 1/3038 24/18639 0.0416666666666667 0.255636932192232 0.986060010882983 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/3038 36/18639 0.0555555555555556 0.340849242922976 0.986820013653408 1 GO:0005179 hormone activity 13/3038 132/18639 0.0984848484848485 0.604232748818002 0.987807309438841 1 GO:0001784 phosphotyrosine residue binding 3/3038 47/18639 0.0638297872340425 0.391614023783844 0.988133237282768 1 GO:0042393 histone binding 28/3038 247/18639 0.11336032388664 0.69549805033676 0.989305755637133 1 GO:0061980 regulatory RNA binding 4/3038 58/18639 0.0689655172413793 0.42312319811128 0.990094208029679 1 GO:0036002 pre-mRNA binding 4/3038 59/18639 0.0677966101694915 0.415951618482275 0.991312648524725 1 GO:0003735 structural constituent of ribosome 18/3038 175/18639 0.102857142857143 0.631058026897395 0.99143830660296 1 GO:0031490 chromatin DNA binding 12/3038 128/18639 0.09375 0.575183097432521 0.991558030221099 1 GO:0030331 nuclear estrogen receptor binding 2/3038 40/18639 0.05 0.306764318630678 0.992911349324359 1 GO:0032451 demethylase activity 2/3038 40/18639 0.05 0.306764318630678 0.992911349324359 1 GO:0061791 GTPase motor activity 2/3038 40/18639 0.05 0.306764318630678 0.992911349324359 1 GO:0071855 neuropeptide receptor binding 2/3038 40/18639 0.05 0.306764318630678 0.992911349324359 1 GO:1990606 membrane scission GTPase motor activity 2/3038 40/18639 0.05 0.306764318630678 0.992911349324359 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 11/3038 122/18639 0.0901639344262295 0.553181558186469 0.993139167556242 1 GO:0030544 Hsp70 protein binding 3/3038 51/18639 0.0588235294117647 0.360899198389033 0.993259405832214 1 GO:0140767 enzyme-substrate adaptor activity 13/3038 139/18639 0.0935251798561151 0.573803761467455 0.993609998126699 1 GO:0004812 aminoacyl-tRNA ligase activity 2/3038 41/18639 0.0487804878048781 0.29928226207871 0.993937440851283 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/3038 41/18639 0.0487804878048781 0.29928226207871 0.993937440851283 1 GO:0140828 metal cation:monoatomic cation antiporter activity 2/3038 41/18639 0.0487804878048781 0.29928226207871 0.993937440851283 1 GO:0035198 miRNA binding 2/3038 42/18639 0.0476190476190476 0.292156493933979 0.994817494472669 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/3038 73/18639 0.0684931506849315 0.420225094014627 0.995168469786997 1 GO:0035064 methylated histone binding 5/3038 74/18639 0.0675675675675676 0.414546376527943 0.995746790091596 1 GO:0008327 methyl-CpG binding 1/3038 31/18639 0.032258064516129 0.197912463632696 0.99599583179612 1 GO:0051059 NF-kappaB binding 1/3038 32/18639 0.03125 0.191727699144174 0.996649564760618 1 GO:0140034 methylation-dependent protein binding 5/3038 76/18639 0.0657894736842105 0.403637261356155 0.996710305016198 1 GO:0140030 modification-dependent protein binding 16/3038 173/18639 0.092485549132948 0.567425329259058 0.997448858257294 1 GO:0051427 hormone receptor binding 1/3038 34/18639 0.0294117647058824 0.180449599194517 0.997654338200389 1 GO:0000049 tRNA binding 5/3038 80/18639 0.0625 0.383455398288348 0.998046084364459 1 GO:0022829 wide pore channel activity 1/3038 37/18639 0.027027027027027 0.165818550611177 0.998626029271537 1 GO:1990841 promoter-specific chromatin binding 3/3038 68/18639 0.0441176470588235 0.270674398791775 0.999448843228874 1 GO:0003823 antigen binding 14/3038 174/18639 0.0804597701149425 0.493643731129827 0.999557302582959 1 GO:0008135 translation factor activity, RNA binding 4/3038 83/18639 0.0481927710843374 0.29567645169222 0.999688591057833 1 GO:0180051 translation factor activity 4/3038 84/18639 0.0476190476190476 0.292156493933979 0.999730532599982 1 GO:0001217 DNA-binding transcription repressor activity 25/3038 278/18639 0.0899280575539568 0.551734386026399 0.999868958242148 1 GO:0003743 translation initiation factor activity 1/3038 51/18639 0.0196078431372549 0.120299732796344 0.999886909868055 1 GO:0001216 DNA-binding transcription activator activity 51/3038 491/18639 0.103869653767821 0.6372700712898 0.999942285468102 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 22/3038 268/18639 0.082089552238806 0.503642911184695 0.99996883246239 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 49/3038 484/18639 0.101239669421488 0.621134364169555 0.99996940008762 1 GO:0003730 mRNA 3'-UTR binding 19/3038 262/18639 0.0725190839694656 0.444925347632281 0.999996264088619 1 GO:0005549 odorant binding 1/3038 111/18639 0.00900900900900901 0.0552728502037258 0.99999999751578 1 GO:0004984 olfactory receptor activity 1/3038 419/18639 0.00238663484486874 0.0146426882401278 1 1 GO:0030371 translation repressor activity 5/3038 329/18639 0.0151975683890578 0.0932414342342487 1 1 GO:0045182 translation regulator activity 7/3038 356/18639 0.0196629213483146 0.120637653394087 1 1