category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/182	133/9376	5.81012971990416	KLRC1/KLRC3/TYROBP/FCER1G/KLRC2/KLRD1/BRAF/PPP3CA/SOS1/GZMB/VAV3/KLRK1/SYK/PRF1/LCP2	7.86041028196558
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/182	67/9376	6.15122191241594	PPP1CB/BRAF/PPP3CA/PRKACB/PLCB1/CAMK2D/RPS6KA2/RAP1B	5.95340226268341
Organismal Systems	Immune system	hsa04611	Platelet activation	10/182	126/9376	4.08860980289552	PPP1CB/FCER1G/PRKACB/PLCB1/STIM1/PPP1R12A/APBB1IP/SYK/LCP2/RAP1B	4.91073540066988
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/182	139/9376	3.70622183571824	MMP9/BCL2/HSPA1A/CTSD/PRKACB/SOS1/PLCB1/FKBP5/NCOA1/NCOA2	4.52245656768312
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/182	232/9376	2.88669950738916	PPP1CB/SSH2/ITGA1/BRAF/ITGAD/ACTR2/IQGAP2/SOS1/IQGAP1/VAV3/CYFIP2/PPP1R12A/ITGA4	4.09399871763744
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/182	115/9376	3.58375537505972	MEF2A/BCL2/BRAF/PRKACB/PLCB1/AKAP13/STK39/PDE4D	3.9222968005058
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/182	203/9376	2.79153358956315	PPP1CB/BCL2/CCND3/ITGA1/BRAF/SOS1/VAV3/CTNNB1/PPP1R12A/RAP1B/ITGA4	3.63066651560067
NA	NA	hsa04517	IgSF CAM signaling	14/182	299/9376	2.41214304090558	NCAM1/SRGAP3/CD96/ACTR2/IQGAP1/VAV3/CTNNB1/UNC5C/ERC1/CASK/LCP2/RAP1B/ARF6/ITGA4	3.49150122761287
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/182	300/9376	2.40410256410256	RASA2/PPM1B/HSPA1A/BRAF/PPP3CA/PRKACB/SOS1/KIT/TAOK3/STK4/RPS6KA2/DUSP6/RAP1B/TGFBR1	3.47761338444226
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/182	216/9376	2.62352462352462	APOA1/MMP9/BCL2/HSPA1A/PPP3CA/NFE2L2/PLCB1/ERN1/VAV3/CAMK2D/RAP1B	3.396308257763
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/182	204/9376	2.52531781943547	MMP9/PPP1CB/BRAF/PRKACB/SOS1/IQGAP1/VAV3/CAMK2D/CTNNB1/PPP1R12A	3.09893514305646
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/182	87/9376	3.55286093217128	BCL2/BRAF/SOS1/CTNNB1/MSH3/TGFBR1	3.36566885943762
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/182	116/9376	3.10875331564987	MMP9/TXK/THY1/VAV3/CTNNB1/RAP1B/ITGA4	3.21527676562063
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/182	212/9376	2.4300228073813	SKAP1/BRAF/PRKD3/PLCB1/VAV3/KIT/CTNNB1/APBB1IP/LCP2/RAP1B	2.96303947066685
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/182	120/9376	3.00512820512821	BCL2/BRAF/SOS1/CAMK2D/RPS6KA2/FOXO3/RAP1B	3.11021333142004
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/182	93/9376	3.32364409783765	YES1/IQGAP1/PTPN1/CTNNB1/RAP1B/TGFBR1	3.16837072170842
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/182	250/9376	2.26672527472527	RAB11FIP1/HSPA1A/SMAP2/VPS37B/RAB11A/ACTR2/EPS15/ACAP2/RAB10/ARF6/TGFBR1	2.85615183184748
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/182	122/9376	2.95586380832283	PTPRC/PPP3CA/SOS1/DLG1/VAV3/PPP2R2B/LCP2	3.05930559339749
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/182	122/9376	2.95586380832283	ATP1B3/KAT2B/PRKACB/PLCB1/CTNNB1/NCOA1/NCOA2	3.05930559339749
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/182	69/9376	3.73307851568721	FCER1G/SOS1/VAV3/SYK/LCP2	3.20583288224819
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/182	69/9376	3.73307851568721	PPP1CB/PPP3CA/PRKACB/MAOA/CAMK2D	3.20583288224819
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/182	45/9376	4.57924297924298	KLRC1/KLRD1/GZMB/PRF1	3.38612063541456
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/182	98/9376	3.15407041937654	PTPRC/ACTR2/VAV3/SYK/PLPP3/ARF6	3.01588538779449
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/182	193/9376	2.4023230655355	BRAF/PRKACB/SOS1/PLCB1/VAV3/XCL2/XCL1/FOXO3/RAP1B	2.7695137281815
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/182	73/9376	3.5285262682523	BRAF/SOS1/EML4/STK4/FOXO3	3.05131098011906
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/182	133/9376	2.71139386928861	PPP1CB/PPP3CA/PRKACB/PLCB1/MAOA/CAMK2D/PPP2R2B	2.79665180566421
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/182	170/9376	2.42430510665805	BRAF/DPF3/SOS1/NFE2L2/ARID2/CTNNB1/SMARCA2/TGFBR1	2.63670224696369
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/182	138/9376	2.61315496098105	ACTR2/SKAP2/VAV3/RPS6KA2/LCP2/ARF6/ITGA4	2.68593646162079
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/182	53/9376	3.88803649181008	ATP1B3/RAB11A/PRKACB/PLCB1	2.96641461143072
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/182	82/9376	3.14124899490753	KLRC1/KLRC3/KLRC2/HSPA1A/KLRD1	2.73994500997163
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/182	178/9376	2.31534757377454	CCND3/PPP3CA/PRKACB/PLCB1/CAMK2D/CTNNB1/INVS/LGR4	2.49271661857726
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/182	149/9376	2.42023748064017	FCER1G/SOS1/PLCB1/KIT/SYK/PLPP3/ARF6	2.4586285819432
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/182	59/9376	3.49264295027007	BRAF/SOS1/CTNNB1/FOXO3	2.70219766619828
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/182	154/9376	2.34165834165834	ATP1B3/PPP1CB/BCL2/PRKACB/PLCB1/CAMK2D/PPP2R2B	2.36188538680393
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/182	226/9376	2.05154137897501	ATP1B3/PPP1CB/BRAF/PRKACB/VAV3/CAMK2D/PPP1R12A/PDE4D/RAP1B	2.25132981156873
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/182	156/9376	2.31163708086785	BRAF/SOS1/PIAS1/EIF2AK2/RSAD2/CTNNB1/PPP2R2B	2.32423270028791
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/182	63/9376	3.27088784231641	KMT2C/KMT2E/CAMKMT/ASH1L	2.54442843860237
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/182	130/9376	2.37768385460693	MMP9/PRKACB/SOS1/PLCB1/GNA15/TGFBR1	2.22542715426189
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/182	98/9376	2.62839201614712	ATP1B3/PRKACB/PRKD3/PLCB1/CAMK2D	2.27989003652012
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/182	238/9376	1.94810231785022	RASA2/RALGAPA1/PLAAT2/PRKACB/SOS1/KIT/STK4/RAP1B/ARF6	2.08442941143836
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/182	68/9376	3.03038138332256	BRAF/SOS1/KIT/DUSP6	2.36413881951104
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/182	99/9376	2.6018426018426	MMP9/BCL2/BRAF/PRKACB/SOS1	2.25425344089441
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/182	99/9376	2.6018426018426	PPP1CB/PRKACB/PRKCH/PLCB1/CAMK2D	2.25425344089441
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/182	168/9376	2.14652014652015	PRL/STAT4/BCL2/CCND3/SOS1/PIAS1/PRLR	2.10970998596356
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/182	134/9376	2.30670821715598	PPP1CB/BRAF/PRKACB/PRKCH/PLCB1/PPP1R12A	2.14346857963184
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/182	205/9376	2.01039935674082	RASA2/CCND3/KAT2B/PRKACB/SP100/DLG1/EIF2AK2/SYK	2.05793061172433
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/182	101/9376	2.55032096616255	PRKACB/PLCB1/CAMK2D/KIT/CTNNB1	2.20391291860455
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/182	71/9376	2.9023370995202	PRL/SOS1/PRLR/FOXO3	2.26374521715049
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/182	137/9376	2.25619635838614	BCL2/CTSD/GZMB/ERN1/CTSW/PRF1	2.08388818615403
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/182	104/9376	2.47675401521555	PLAAT2/GPCPD1/ETNK1/LCLAT1/PLPP3	2.13062589503558
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/182	174/9376	2.07250221043325	BCL2/HSPA1A/MAN1A1/NFE2L2/ERN1/SEC24B/HSPH1	2.00909645846235
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/182	106/9376	2.4300228073813	MMP9/BCL2/BRAF/SOS1/CTNNB1	2.083171916322
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/182	107/9376	2.40731231385437	PPP3CA/PRKACB/PLCB1/CAMK2D/PPP4R3A	2.05984725920407
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/182	75/9376	2.74754578754579	ATP1B3/PRKACB/PLCB1/TTF2	2.13778219452894
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/182	142/9376	2.17675282464015	BIRC6/PIAS1/UBE2W/UBA6/HUWE1/UBE2H	1.98794135780254
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	11/182	333/9376	1.7017457017457	MAML3/CCND3/ITGA1/PRKACB/SOS1/ISG15/DLG1/EIF2AK2/CTNNB1/PPP2R2B/ITGA4	1.83448723884382
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/182	76/9376	2.71139386928861	ATP1B3/PRKACB/PLCB1/CAMK2D	2.10758149263663
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/182	181/9376	1.99235019124522	BCL2/FCER1G/CTSD/PPP3CA/CAMK2D/LSP1/SYK	1.89669483198474
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/182	184/9376	1.95986622073579	SSH2/PPP3CA/SEMA3B/SRGAP3/SEMA3A/CAMK2D/UNC5C	1.85005097392524
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/182	80/9376	2.57582417582418	BCL2/BRAF/SOS1/FOXO3	1.9914700412441
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/182	115/9376	2.23984710941233	BCL2/PRKACB/PLCB1/KCNQ5/CAMK2D	1.88216283836543
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/182	154/9376	2.00713572142144	PPP1CB/PPP3CA/PRKACB/PLCB1/CAMK2D/PPP1R12A	1.77298427557444
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/182	155/9376	1.99418645870259	BRAF/PRKACB/PLCB1/CAMK2D/CTNNB1/RAP1B	1.75595654487997
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/182	157/9376	1.96878280954714	PPP1CB/CCND3/DLG1/CTNNB1/PPP2R2B/TGFBR1	1.72227867843939
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/182	86/9376	2.39611551239458	ATP1B3/PRKACB/PLCB1/CAMK2D	1.8299187357672
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/182	158/9376	1.9563221588538	CCND3/CDKN1C/CCNH/CDC14A/NIPBL/PDS5B	1.70562476414331
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/182	26/9376	3.96280642434489	APOA1/LMBRD1	2.12839989441906
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	11/182	362/9376	1.56541800740696	PRL/BCL2/CCND3/ITGA1/SOS1/KIT/PRLR/FOXO3/PPP2R2B/SYK/ITGA4	1.54359806914263
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/182	56/9376	2.75981161695447	MGAT5/FUT8/MAN1A1	1.85832350486531
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/182	125/9376	2.06065934065934	BCL2/FCER1G/CTSD/PLCB1/PPP2R2B	1.67959923990087
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/182	27/9376	3.81603581603582	ELOVL5/ELOVL6	2.06161022154686
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/182	163/9376	1.89631227668038	STAT4/MMP9/BCL2/BRAF/SOS1/TGFBR1	1.62413338660732
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/182	91/9376	2.26446081391136	PPP3CA/SOS1/VAV3/SYK	1.70531337993293
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/182	28/9376	3.67974882260597	ELOVL5/ELOVL6	1.99794180915487
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/182	166/9376	1.86204157288495	ATP1B3/MEF2A/PPP1CB/PPP3CA/PLCB1/PPP1R12A	1.5765999993819
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/182	93/9376	2.21576273189176	PRKACB/SOS1/PLCB1/CAMK2D	1.65773538548985
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/182	248/9376	1.66182204891882	BCL2/PTPRC/ACTR2/CYFIP2/CTNNB1/VPS41/ABI1/ARF6	1.48610104300998
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/182	169/9376	1.82898758046687	BCL2/BIRC6/CTSD/PRKACB/ERN1/VPS41	1.53003507700779
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/182	133/9376	1.93670990663472	BRAF/SOS1/STK4/FOXO3/TGFBR1	1.53071218658886
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/182	62/9376	2.49273307337823	HSPA1A/PRKACB/FOXO3	1.65912445866361
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/182	63/9376	2.45316588173731	CCNH/MNAT1/POLR2J	1.62820749074401
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/182	32/9376	3.21978021978022	BCL2/BIRC6	1.76965103277732
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/182	138/9376	1.86653925784361	PPP1CB/PPP3CA/PRKACB/CAMK2D/RPS6KA2	1.44280583351552
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/182	138/9376	1.86653925784361	PPP1CB/BRAF/PRKACB/SOS1/PTPN1	1.44280583351552
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/182	102/9376	2.02025425554837	ATP1B3/RAB11A/PLCB1/RAP1B	1.45761905649034
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/182	103/9376	2.00064013656247	PLCB1/PPP2R2B/GNA15/TGFBR1	1.43666490790648
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/182	142/9376	1.81396068720012	TYROBP/PPP3CA/SYK/LCP2/TGFBR1	1.37506031838532
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/182	142/9376	1.81396068720012	MEF2A/MMP9/BCL2/NFE2L2/CTNNB1	1.37506031838532
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/182	105/9376	1.96253270538985	FCER1G/PPP3CA/LSP1/SYK	1.39545532278347
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/182	144/9376	1.78876678876679	ATXN10/PLCB1/ERN1/PUM1/PUM2	1.3419954607849
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/182	69/9376	2.23984710941233	PPP3CA/PRKACB/PLCB1	1.45430971320449
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/182	70/9376	2.20784929356358	BRAF/SOS1/RAP1B	1.42708331332954
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/182	148/9376	1.74042174042174	BRAF/SOS1/KIT/CTNNB1/NCOA1	1.27739528669264
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/182	37/9376	2.78467478467479	APOA1/PLCB1	1.53030798527907
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/182	37/9376	2.78467478467479	BRAF/CTNNB1	1.53030798527907
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/182	150/9376	1.71721611721612	BCL2/BRAF/SOS1/CTNNB1/TGFBR1	1.24582782754283
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/182	73/9376	2.11711576095138	MDFIC/KAT2B/MLLT3	1.3480847046177
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/182	39/9376	2.64187094956326	GZMB/PRF1	1.44556200694831
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/182	75/9376	2.06065934065934	BCL2/CCND3/ZMAT3	1.29751029648654
NA	NA	hsa04518	Integrin signaling	5/182	154/9376	1.67261310118453	CCND3/ITGA1/ITGAD/CTNNB1/ITGA4	1.18408316434496
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/182	76/9376	2.03354540196645	BRAF/SOS1/CAMK2D	1.27281112786133
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/182	115/9376	1.79187768752986	BRAF/PRKACB/PLCB1/MAOA	1.20211818431864
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/182	77/9376	2.00713572142144	BRAF/SOS1/TGFBR1	1.24848785259727
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/182	41/9376	2.51299919592603	BABAM2/RAD51B	1.36597435817068
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/182	41/9376	2.51299919592603	MMP9/BRAF	1.36597435817068
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/182	157/9376	1.64065234128928	ADAM10/XKR6/CAMK2D/VPS41/ATP8A1	1.13893625776719
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/182	157/9376	1.64065234128928	PPP1CB/CCND3/PPP3CA/FOXO3/TGFBR1	1.13893625776719
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/182	117/9376	1.76124729970884	DPF3/BAZ1A/ARID2/SMARCA2	1.1657508382892
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/182	43/9376	2.39611551239458	APOA1/PLPP3	1.2909636977961
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/182	205/9376	1.50779951755562	MMP9/PPP1CB/CTSD/PLCB1/CAMK2D/TGFBR1	1.03426052760701
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/182	12/9376	4.29304029304029	NCAM1	1.60592791650898
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/182	44/9376	2.34165834165834	FUT8/MAN1A1	1.25501810449372
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/182	44/9376	2.34165834165834	CCNH/MNAT1	1.25501810449372
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/182	44/9376	2.34165834165834	GZMB/PRF1	1.25501810449372
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/182	44/9376	2.34165834165834	RAB11A/PRKACB	1.25501810449372
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/182	254/9376	1.41974560872199	PPP3CA/PRKACB/PLCB1/STIM2/STIM1/CAMK2D/GNA15	0.954172878985139
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/182	86/9376	1.79708663429594	BRAF/SOS1/CAMK2D	1.04475865584073
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/182	86/9376	1.79708663429594	ITGA1/CTNNB1/ITGA4	1.04475865584073
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/182	48/9376	2.14652014652015	ATP1B3/PLCB1	1.1204103781842
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/182	14/9376	3.67974882260597	FUT8	1.41170148223848
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/182	49/9376	2.10271361291769	PRKACB/MAOA	1.08882697088544
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/182	89/9376	1.7365106803309	PRKACB/SOS1/PLCB1	0.982212398794213
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/182	91/9376	1.69834561043352	PDE7A/PRKACB/PDE4D	0.941822870418501
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/182	51/9376	2.02025425554837	PLAAT2/PLPP3	1.02786993973331
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	6/182	224/9376	1.37990580847724	CCND3/PPP3CA/KAT2B/PRKACB/DLG1/TGFBR1	0.809675539953452
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/182	16/9376	3.21978021978022	MAOA	1.25026227342213
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/182	93/9376	1.66182204891882	STAT4/MAML3/PPP3CA	0.902417717380569
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/182	93/9376	1.66182204891882	ATP1B3/PRKACB/PLCB1	0.902417717380569
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/182	136/9376	1.51519069166128	BCL2/CCND3/HSPA1A/EIF2AK2	0.851472367929109
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/182	180/9376	1.43101343101343	PPP1CB/BCL2/SP100/EIF2AK2/SYK	0.821479362423873
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/182	227/9376	1.36166916783657	PPP3CA/PRKACB/SOS1/PLCB1/AKAP13/CTNNB1	0.776080344177748
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/182	227/9376	1.36166916783657	BRAF/PRKD3/SOS1/NFE2L2/PTPN1/FOXO3	0.776080344177748
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/182	54/9376	1.90801790801791	GZMB/PRF1	0.941468571735638
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/182	140/9376	1.47189952904239	MEF2A/PRKACB/PLCB1/TGFBR1	0.791481343179649
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/182	55/9376	1.87332667332667	B4GALT5/PLPP3	0.913894151221617
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/182	97/9376	1.59329330463351	PRKACB/PLCB1/CAMK2D	0.826368605483233
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/182	56/9376	1.83987441130298	BCL2/PRKACB	0.886889451474523
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/182	18/9376	2.86202686202686	LMBRD1	1.11249932598073
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/182	99/9376	1.56110556110556	SOS1/GPCPD1/PLPP3	0.789636972054692
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/182	57/9376	1.80759591285907	ELOVL5/ELOVL6	0.860430837274198
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/182	100/9376	1.54549450549451	ITGA1/KIT/ITGA4	0.771576679784899
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/182	101/9376	1.53019257969753	BCL2/PLCB1/TGFBR1	0.753713780080004
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/182	191/9376	1.34859904493412	PPP1CB/BRAF/PRKACB/SOS1/MAOA	0.684813603351171
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/182	59/9376	1.74632147513503	PLAAT2/PRKACB	0.809064189528245
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/182	103/9376	1.50048010242185	PPP1CB/PPP2R2B/RNGTT	0.71856222230401
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/182	103/9376	1.50048010242185	PRKACB/PLCB1/GNA15	0.71856222230401
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/182	60/9376	1.71721611721612	BRAF/PLCB1	0.784115444601376
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/182	105/9376	1.47189952904239	BCL2/ERC1/SYK	0.684147879790223
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/182	105/9376	1.47189952904239	ARIH1/HUWE1/FOXO3	0.684147879790223
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/182	105/9376	1.47189952904239	ITGA1/PRKACB/ITGA4	0.684147879790223
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/182	21/9376	2.45316588173731	DPYD	0.937933454379166
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/182	62/9376	1.66182204891882	MAML3/KAT2B	0.735593769728083
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/182	200/9376	1.28791208791209	ACTR2/CYFIP2/SEC24B/ABI1/ARF6	0.579051614536088
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/182	22/9376	2.34165834165834	MAOA	0.886387606892123
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/182	201/9376	1.28150456508665	MMP9/FUT8/MLLT3/GZMB/DUSP6	0.567609318654736
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/182	109/9376	1.41788486742615	PPP1CB/PTPN1/RPS6KA2	0.617403937069446
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/182	298/9376	1.21011874032008	PRL/IL1RL1/TNFRSF18/XCL2/PRLR/XCL1/TGFBR1	0.518617197285317
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/182	110/9376	1.404995004995	BRAF/PRKACB/RPS6KA2	0.601130749649573
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/182	65/9376	1.58512256973795	LCLAT1/PLPP3	0.666000335292973
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/182	65/9376	1.58512256973795	PRKACB/PLCB1	0.666000335292973
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/182	23/9376	2.23984710941233	MSH3	0.837578782270741
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/182	23/9376	2.23984710941233	LNPEP	0.837578782270741
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/182	23/9376	2.23984710941233	ATP1B3	0.837578782270741
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/182	205/9376	1.25649959796301	BCL2/CCND3/ISG15/EIF2AK2/SYK	0.522425485548353
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/182	253/9376	1.22173478695218	BCL2/ACTR2/SEPTIN7/PLCB1/FOXO3/ARF6	0.503030523570918
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/182	160/9376	1.28791208791209	NCAM1/PTPRC/GLG1/ITGA4	0.516794329540082
NA	NA	hsa04519	Cadherin signaling	9/182	404/9376	1.14764443477315	PPP1CB/KRT86/ADAM10/ACTR2/KRT81/VAV3/CYFIP2/CTNNB1/TAOK3	0.426807668796973
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/182	116/9376	1.33232284956423	PPP3CA/PRKACB/PLCB1	0.506702196486845
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/182	70/9376	1.47189952904239	EIF4G3/PRF1	0.5575529555327
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/182	26/9376	1.98140321217244	PLAAT2	0.705013488565057
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/182	168/9376	1.22658294086866	STAT4/BCL2/CAMK2D/EIF2AK2	0.416934926482073
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/182	217/9376	1.18701574922773	BCL2/CCND3/PRKACB/SOS1/RPS6KA2	0.392150796442584
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/182	170/9376	1.21215255332902	PRKACB/ACTR2/DLG1/PPP2R2B	0.392741071731634
NA	NA	hsa04081	Hormone signaling	5/182	219/9376	1.17617542275077	PRL/PRKACB/PLCB1/PRLR/GNA15	0.371158879640845
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/182	122/9376	1.2667987749955	FOXO3/PPP2R2B/RAB10	0.417318926390502
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/182	122/9376	1.2667987749955	PRKACB/SOS1/PLCB1	0.417318926390502
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/182	75/9376	1.37377289377289	BCL2/MSH3	0.457238398444145
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/182	173/9376	1.19113256685511	CCND3/RAB11A/EIF2AK2/RSAD2	0.356994985049875
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/182	77/9376	1.33809048094762	BRAF/TGFBR1	0.419111197789844
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/182	30/9376	1.71721611721612	PLAAT2	0.553562754804487
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/182	78/9376	1.32093547478163	XRN1/DHX36	0.400441738003746
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/182	78/9376	1.32093547478163	ACTR2/CTNNB1	0.400441738003746
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/182	31/9376	1.66182204891882	DPYD	0.519279895037429
Human Diseases	Immune disease	hsa05310	Asthma	1/182	32/9376	1.60989010989011	FCER1G	0.486216001579906
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/182	83/9376	1.24136104858996	AUTS2/SFMBT2	0.310740130690355
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/182	235/9376	1.09609539396773	DPF3/PRKACB/SOS1/RPS6KA2/SMARCA2	0.209898207974784
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/182	34/9376	1.51519069166128	POLR2J	0.423405618999936
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/182	86/9376	1.19805775619729	PRKACB/PLCB1	0.259598575914256
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/182	36/9376	1.43101343101343	B4GALT5	0.364533712343198
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/182	88/9376	1.17082917082917	CFH/SERPING1	0.226522501077492
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/182	37/9376	1.39233739233739	MAOA	0.336418180821043
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/182	89/9376	1.15767378688727	ITGA1/ITGA4	0.210274138015123
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/182	90/9376	1.14481074481074	PRKACB/FOXO3	0.194212323834658
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/182	90/9376	1.14481074481074	ATP1B3/PRKACB	0.194212323834658
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/182	90/9376	1.14481074481074	PPP3CA/EML4	0.194212323834658
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/182	38/9376	1.3556969346443	ATP1B3	0.309110721269871
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/182	38/9376	1.3556969346443	PTPRC	0.309110721269871
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/182	196/9376	1.05135680645885	PPP3CA/EIF2AK2/CTNNB1/SYK	0.102228923495408
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/182	144/9376	1.07326007326007	TRA2B/CTNNB1/FOXO3	0.124643541249371
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/182	250/9376	1.03032967032967	CTSD/OSBPL3/CTSW/VPS41/GNPTAB	0.0683858964527295
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/182	94/9376	1.09609539396773	MMP9/USP25	0.131739132369537
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/182	41/9376	1.25649959796301	MAOA	0.231574395176146
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/182	42/9376	1.22658294086866	MAOA	0.207055627574186
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/182	99/9376	1.04073704073704	ITGA1/ITGA4	0.0573287376348312
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/182	100/9376	1.03032967032967	XCL2/XCL1	0.042899912091183
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/182	158/9376	0.978161079426902	BRAF/SOS1/RPS6KA2	-0.0389502673411634
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/182	103/9376	1.00032006828123	ATP1B3/COL14A1	0.000459536701537376
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/182	268/9376	0.961128423814991	PRKACB/NFE2L2/MAOA/ERN1/CAMK2D	-0.0908358154982153
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/182	50/9376	1.03032967032967	MAOA	0.0302533915939086
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/182	50/9376	1.03032967032967	ITGA4	0.0302533915939086
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/182	50/9376	1.03032967032967	KLRK1	0.0302533915939086
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/182	109/9376	0.945256578284101	PPP3CA/TGFBR1	-0.0808806605135608
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/182	388/9376	0.929421094369548	BRAF/PPP3CA/ADAM10/PLCB1/ERN1/EIF2AK2/CTNNB1	-0.199769109405822
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/182	51/9376	1.01012712777419	PRKACB	0.0102027216826749
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/182	110/9376	0.936663336663337	BCL2/CAMK2D	-0.0940100876363664
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/182	52/9376	0.990701606086222	PRKACB	-0.00945970432972719
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/182	52/9376	0.990701606086222	APOA1	-0.00945970432972719
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/182	112/9376	0.919937205651491	BCL2/HSPA1A	-0.119924955059548
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/182	233/9376	0.884403150497571	ATP1B3/ITGA1/FBN2/ITGA4	-0.251390395382821
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/182	56/9376	0.919937205651491	HSPA1A	-0.084544601916263
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/182	59/9376	0.873160737567517	DPYD	-0.137502548806772
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/182	60/9376	0.858608058608059	PPP3CA	-0.15458047069261
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/182	61/9376	0.844532516663664	ATP1B3	-0.171388681898455
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/182	63/9376	0.817721960579103	PLAAT2	-0.204234404972692
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/182	63/9376	0.817721960579103	CTNNB1	-0.204234404972692
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/182	128/9376	0.804945054945055	PDE7A/PDE4D	-0.31261306310098
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/182	65/9376	0.792561284868977	PLCB1	-0.236111647328656
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/182	66/9376	0.780552780552781	STAT4	-0.251707578804199
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/182	71/9376	0.72558427488005	ADAM10	-0.326549529737843
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/182	71/9376	0.72558427488005	KIT	-0.326549529737843
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/182	72/9376	0.715506715506716	ISG15	-0.340935715486918
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/182	73/9376	0.705705253650459	MAOA	-0.355141570883655
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/182	73/9376	0.705705253650459	BRAF	-0.355141570883655
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/182	144/9376	0.715506715506716	ZFHX3/CTNNB1	-0.484032418518392
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/182	76/9376	0.677848467322152	APOA1	-0.396729601689289
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/182	78/9376	0.660467737390814	PLCB1	-0.423645561277009
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/182	78/9376	0.660467737390814	SERPING1	-0.423645561277009
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/182	78/9376	0.660467737390814	ITGA4	-0.423645561277009
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/182	275/9376	0.749330669330669	NCAM1/HSPA1A/PPP3CA/PRKACB	-0.593597514222999
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/182	149/9376	0.691496423040047	PRKACB/PLCB1	-0.53406259325276
NA	NA	hsa04382	Cornified envelope formation	3/182	217/9376	0.712209449536639	KRT86/KRT81/PPP2R2B	-0.603464114861414
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/182	82/9376	0.628249798981506	DPYD	-0.475692042662492
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/182	87/9376	0.592143488695213	ATP1B3	-0.537714350953642
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/182	89/9376	0.578836893443635	PRKACB	-0.561664122763967
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	7/182	480/9376	0.751282051282051	BCL2/BRAF/PPP3CA/PLCB1/ERN1/CAMK2D/CTNNB1	-0.787044777186114
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/182	93/9376	0.553940682972941	BCL2	-0.608217618838002
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/182	238/9376	0.649367439283406	ISG15/EIF2AK2/SYK	-0.770875472409804
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/182	98/9376	0.525678403229424	PLCB1	-0.66409136857734
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/182	99/9376	0.52036852036852	CFH	-0.674979496785029
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/182	187/9376	0.550978433331374	BCL2/PLCB1	-0.872615576066665
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/182	110/9376	0.468331668331668	TGFBR1	-0.789150924922306
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/182	195/9376	0.528374189912651	PLCB1/SYK	-0.936351603699757
NA	NA	hsa04082	Neuroactive ligand signaling	2/182	199/9376	0.517753603180739	PRKACB/PLCB1	-0.967418183898226
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/182	119/9376	0.432911626188937	MMP9	-0.87590735873912
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/182	214/9376	0.481462462770874	BCL2/PPP3CA	-1.07959540175658
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/182	308/9376	0.501783930355359	PLCB1/ERN1/POLR2J	-1.2508534085249
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/182	243/9376	0.424003979559535	HSPA1A/TRA2B	-1.27992633031195
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/182	323/9376	0.47848127105093	MMP9/BCL2/SOS1	-1.34197366421341
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/182	157/9376	0.328130468257857	ERN1	-1.19443342492159
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/182	183/9376	0.281510838887888	XRN1	-1.38097627713787
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/182	368/9376	0.419971333014811	BCL2/PPP3CA/ERN1	-1.59708584841939
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/182	449/9376	0.344208130399667	NCALD/PRKACB/CAMK2D	-2.0035745829416
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/182	370/9376	0.278467478467478	PRL/PRLR	-1.99232362091945