category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	62/1775	138/9376	2.3731863645642	NDUFB4/ATP6V1F/NDUFC1/NDUFC2/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/ATP6V1A/NDUFB3/NDUFA8/ATP6AP1/COX5A/NDUFS7/COX7A1/NDUFS2/ATP6V0B/COX17/NDUFA7/COX5B/CYCS/COX6A1/NDUFS6/ATP5ME/NDUFA3/UQCR11/COX6B1/NDUFA2/ATP6V0C/SDHD/UQCRQ/UQCRH/NDUFAB1/ATP5MC1/COX7C/ATP6V1E1/UQCR10/ATP6V1G1/PPA1/NDUFB11/ATP5MC2/ATP5PD/NDUFA13/COX7B/CYC1/ATP5PF/UQCRB/ATP5MG/COX10/NDUFB2/MT-ND4/MT-CO2/NDUFA4/ATP6V1B2/UQCRC1/ATP6V0A2/MT-ND3/ATP6V0E1/MT-ND1/MT-ND2	7.85288969482188
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	89/1775	235/9376	2.00051303566077	CREB5/ADCY4/FGFR1/NDUFB4/KRAS/MAP2K3/NDUFC1/NDUFAF3/NDUFC2/NDUFB9/NDUFA12/RPS6KA2/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/COX14/NDUFA8/CREB1/PRKAA1/COX20/COX5A/PNPLA2/NDUFS7/COX7A1/ACSL5/MAPK14/NDUFS2/RPS6KA3/COX17/NDUFA7/COX5B/COX6A1/SMARCD1/NDUFS6/ATP5ME/NDUFA3/UQCR11/COX6B1/NDUFAF8/NDUFA2/SDHD/UQCRQ/NRAS/UQCRH/NDUFAB1/SOS2/ATP5MC1/COX7C/UQCR10/MAPK12/NDUFB11/ATP5MC2/COA1/ATP5PD/ACSL3/RHEB/COA5/NDUFA13/COX7B/CYC1/ATP5PF/SOS1/NDUFAF4/PRKAG1/UQCRB/ATP5MG/MTOR/COX10/NDUFB2/HRAS/MT-ND4/MT-CO2/NDUFA4/ADCY6/SIRT6/COX19/UQCRC1/MT-ND3/COA6/MT-ND1/PRKAB2/SLC25A20/RPS6KB2/COA7/MT-ND2/GNAS/PLIN1	7.50601242038631
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	84/1775	227/9376	1.9546665012099	MGST2/ABL2/PIK3R3/MGST3/NOX4/NDUFB4/PRKD3/KRAS/NDUFC1/NDUFC2/SLC25A5/NDUFB9/NQO1/AHR/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/NDUFA8/RAC1/PRKD2/COX5A/NDUFS7/COX7A1/MAPK14/NDUFS2/RELA/NDUFA7/COX5B/MAPK3/COX6A1/PTPN1/NDUFS6/NDUFA3/UQCR11/COX6B1/MAP2K4/NDUFA2/SDHD/UQCRQ/NRAS/UQCRH/NDUFAB1/AKR1C3/SOS2/ATP5MC1/COX7C/UQCR10/MAPK12/NDUFB11/ATP5MC2/MAPK8/PRKD1/ATP5PD/PLD1/MET/EPHX1/SLC26A2/NDUFA13/COX7B/CYC1/ATP5PF/CHUK/SOS1/UQCRB/AKT3/ARAF/NDUFB2/EPHX4/HRAS/MT-ND4/MT-CO2/IKBKG/MAP3K14/NDUFA4/NFKBIA/UQCRC1/BRAF/MT-ND3/MT-ND1/GSTM4/MT-ND2	7.03602297773695
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/1775	205/9376	1.93253177602199	REN/PIK3R3/MMP9/NDUFB4/TGFBR1/NDUFC1/CTSD/NDUFC2/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/TBC1D4/SMAD3/NDUFA8/PPP1CA/RAC1/PPP1CC/SMAD2/PTPA/COX5A/NDUFS7/COX7A1/MAPK14/NDUFS2/RELA/NDUFA7/COX5B/COX6A1/NDUFS6/NDUFA3/UQCR11/COX6B1/NDUFA2/SDHD/UQCRQ/UQCRH/NDUFAB1/ATP5MC1/SP1/COX7C/UQCR10/NOS3/MAPK12/NDUFB11/ATP5MC2/MAPK8/ATP5PD/PPP1CB/NDUFA13/COX7B/CYC1/ATP5PF/UQCRB/AKT3/MTOR/NDUFB2/RYR2/MT-ND4/MT-CO2/NDUFA4/ACE/TGFB2/GAPDH/TGFB3/UQCRC1/MT-ND3/CAMK2G/PDK2/MT-ND1/MT-ND2	6.52351512654854
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	85/1775	248/9376	1.81044979554748	LY96/LEF1/TUBB6/RHOJ/ARPC5L/ARF6/S100A10/PODXL/KPNA4/MAP2K3/NCKAP1/RHOG/TNFRSF1A/KPNA1/GSDMD/NOD1/ACBD3/RAC1/TNFSF10/ARL8A/CYTH2/KLC1/MAPK14/BAX/IL6/PLEKHM1/RELA/MAPK3/ACTR1A/CYCS/DYNLRB1/KPNA3/MLKL/MYL12A/RIPK2/TNFRSF10A/TUBB2A/DYNLL2/MAP2K4/PFN1/DYNC1LI2/ARPC1A/TNFRSF10B/PIK3C2A/MYD88/MYC/FHOD1/TRAF6/ACTR10/RHOB/MAPK12/ARPC3/MAPK8/DCTN6/PIK3C2B/BRK1/CASP1/EXOC2/RALA/MYO6/DYNC1LI1/CYTH3/ACTR2/TUBA1A/PYCARD/CHUK/CYTH1/ARPC1B/AKT3/IRAK1/TUBA4A/HRAS/ROCK2/ACTR3/TUBA1B/RILP/IKBKG/TIRAP/BIRC3/NFKBIA/GAPDH/DYNLL1/SNX9/HSP90B1/TLR5	6.25048320217725
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	36/1775	77/9376	2.46962502286446	PIK3R3/CDKN1A/TGFBR1/KRAS/SHC1/SMAD3/CRK/BAX/RELA/MAPK3/STAT5A/CBL/BCR/SMAD4/HDAC1/NRAS/BCL2L1/SOS2/MYC/HDAC2/SHC2/CHUK/SOS1/AKT3/ARAF/POLK/HRAS/DDB2/IKBKG/GADD45B/NFKBIA/TGFB2/TGFB3/CTBP2/MECOM/BRAF	6.25724597079797
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	97/1775	308/9376	1.66356685567953	POLR2J/CREB5/TUBB6/POLR2K/ADRM1/NDUFB4/NDUFC1/NDUFC2/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/POLR2I/NDUFA8/POLR2F/CREB1/PSMD7/COX5A/KLC1/POLR2E/NDUFS7/COX7A1/BAX/NDUFS2/NDUFA7/ATG2B/COX5B/CLTB/HTT/ACTR1A/CYCS/COX6A1/NDUFS6/PSMB2/NDUFA3/UQCR11/TFAM/POLR2G/TUBB2A/COX6B1/NDUFA2/SIN3A/SDHD/UQCRQ/HDAC1/PSMC6/UQCRH/NDUFAB1/ATP5MC1/GPX7/HIP1/SP1/COX7C/TBPL1/ACTR10/UQCR10/PSMB6/NDUFB11/ATG101/ATP5MC2/MAPK8/DCTN6/REST/PSMD6/HDAC2/ATP5PD/NDUFA13/COX7B/TUBA1A/CYC1/ATP5PF/UQCRB/PSMA2/MTOR/AP2S1/NDUFB2/TUBA4A/MT-ND4/PIK3R4/TUBA1B/MT-CO2/NDUFA4/TBP/SLC1A2/UQCRC1/POLR2C/PSMA7/MT-ND3/MT-ND1/GRM5/DNAL1/MT-ND2/BBC3	5.722077539288
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	58/1775	157/9376	1.95140575939715	LEPR/PIK3R3/NDUFB4/MAP3K11/NDUFC1/NDUFC2/TNFRSF1A/NDUFB9/NDUFA12/COX7A2/COX8A/UQCRFS1/ADIPOR1/NDUFB3/NDUFA8/PRKAA1/RAC1/EIF2S1/COX5A/NDUFS7/COX7A1/MAPK14/SOCS3/BAX/NDUFS2/IL6/RELA/NDUFA7/COX5B/CYCS/COX6A1/NDUFS6/NDUFA3/UQCR11/COX6B1/NDUFA2/SDHD/UQCRQ/UQCRH/NDUFAB1/ADIPOR2/COX7C/UQCR10/MAPK12/NDUFB11/MAPK8/NDUFA13/COX7B/CYC1/PRKAG1/UQCRB/AKT3/NDUFB2/MT-CO2/MLX/NDUFA4/UQCRC1/PRKAB2	5.80929118316387
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	86/1775	268/9376	1.69505150304814	TUBB6/CALML4/GNAI2/MAOA/SLC39A8/ADRM1/UBE2J1/NDUFB4/DUSP1/NDUFC1/NDUFC2/PINK1/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/NDUFA8/PSMD7/EIF2S1/COX5A/KLC1/NDUFS7/COX7A1/BAX/NDUFS2/SLC39A10/NDUFA7/COX5B/CYCS/COX6A1/SNCA/NDUFS6/PSMB2/NDUFA3/UQCR11/TUBB2A/COX6B1/NDUFA2/SDHD/UQCRQ/PSMC6/BCL2L1/UQCRH/NDUFAB1/UBE2G2/ATP5MC1/COX7C/UQCR10/PSMB6/NDUFB11/ATP5MC2/SLC39A4/MAPK8/PSMD6/ATP5PD/RPS27A/GNAI3/SLC39A7/NDUFA13/COX7B/TUBA1A/CYC1/ATF6/ATP5PF/UQCRB/PSMA2/NDUFB2/TUBA4A/MT-ND4/TUBA1B/MT-CO2/NDUFA4/CALM1/UBA52/UQCRC1/PSMA7/MT-ND3/CAMK2G/CALM2/MT-ND1/MT-ND2/GNAS	5.57856276208067
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	63/1775	180/9376	1.84878873239437	BST2/CCL2/IFNAR2/HLA-C/PIK3R3/TICAM1/IRF7/TNFRSF1A/ITGA5/IFIH1/PPP1CA/HLA-F/HLA-A/OAS2/PPP1CC/B2M/EIF2S1/HLA-DMA/SOCS3/BAX/IL6/IFNAR1/TAPBPL/RELA/HLA-E/CYCS/IFNGR1/SRSF8/SRSF1/BCL2L1/MYD88/SRSF2/EIF4EBP1/TRAF6/IRF9/EIF2B2/SRSF9/HLA-DRB1/PML/RHEB/PPP1CB/SP100/HCFC1/TYK2/ALYREF/CD74/OAS3/CHUK/NECTIN2/SRSF5/AKT3/MTOR/IRAK1/HLA-DRB5/PILRB/IKBKG/SRSF4/BIRC3/NFKBIA/TAP2/OAS1/HLA-B/JAK1	5.55630180558645
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	43/1775	110/9376	2.06488092189501	ID3/ID1/SMAD9/SKIL/LTBP1/TGFBR1/PPP2R1A/RBX1/BMP6/SMAD6/SMAD3/LRRC32/PPP2R1B/SMAD2/THBS1/E2F4/MAPK3/SMURF2/SMURF1/SMAD1/TGIF1/SMAD4/SIN3A/HDAC1/SP1/MYC/TGIF2/TFDP1/ACVR1/CUL1/HDAC2/CHRD/FST/RGMB/ACVR2B/TGFB2/BMP2/TGFB3/E2F5/BAMBI/RPS6KB2/ACVR1B/BMPR2	5.42876061655517
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	79/1775	250/9376	1.66919211267606	EHD4/HSPA1B/ARPC5L/HLA-C/CHMP1B/ARF6/HSPA1A/CAV2/SPG21/TGFBR1/ARF3/LDLR/AGAP3/EPN1/CHMP5/SMAD3/RAB22A/HLA-F/GIT1/HLA-A/SMAD2/CYTH2/DNM3/ARF5/HLA-E/MVB12A/RAB11B/CLTB/SH3GL1/ARAP3/SMURF2/VPS26A/SMURF1/SNX3/MVB12B/PRKCI/CBL/NEDD4/IGF2R/RAB11FIP3/ARPC1A/CAPZA2/PDCD6IP/VPS29/SH3GLB1/ASAP2/TRAF6/ARFGEF2/WWP1/ARPC3/IQSEC1/CHMP1A/NEDD4L/PML/PLD1/ASAP1/RAB11FIP5/CYTH3/RAB35/VPS36/ACTR2/GRK5/CYTH1/WASHC2A/ARPC1B/AP2S1/SH3GLB2/RNF41/HRAS/RAB11A/ACTR3/CHMP4C/VPS37C/VTA1/CHMP7/HGS/IQSEC2/HLA-B/LDLRAP1	5.1823893279272
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	112/1775	388/9376	1.52477421228401	TUBB6/CALML4/PIK3R3/NOX4/SLC39A8/ADRM1/NDUFB4/KRAS/BACE2/NDUFC1/APH1A/FZD6/NDUFC2/TNFRSF1A/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/NDUFA8/PSMD7/CSNK2B/EIF2S1/COX5A/KLC1/CSNK1E/NDUFS7/COX7A1/NDUFS2/IL6/SLC39A10/RELA/NDUFA7/NCSTN/ATG2B/COX5B/MAPK3/CYCS/COX6A1/AXIN2/SNCA/NDUFS6/PSMB2/NDUFA3/UQCR11/TUBB2A/COX6B1/NDUFA2/SDHD/UQCRQ/PSMC6/NRAS/UQCRH/NDUFAB1/ATP5MC1/COX7C/APP/UQCR10/PSMB6/NDUFB11/ATG101/ATP5MC2/SLC39A4/MAPK8/PSMD6/CDK5/ATP5PD/MME/LRP6/SLC39A7/NDUFA13/COX7B/TUBA1A/CYC1/ATF6/ATP5PF/FZD4/CHUK/RTN4/CSF1/UQCRB/PSMA2/AKT3/MTOR/WNT2B/ARAF/NDUFB2/TUBA4A/HRAS/WNT6/MT-ND4/PIK3R4/LRP5/CHRNA7/TUBA1B/MT-CO2/IKBKG/NDUFA4/CALM1/GAPDH/UQCRC1/AXIN1/PSMA7/BRAF/MT-ND3/CALM2/MT-ND1/GRM5/MT-ND2	5.10159839041097
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	78/1775	250/9376	1.64806309859155	GNS/AP1S2/NPC1/LAPTM4B/HYAL2/TPP1/ATP6V1F/ASAH1/CTSD/ATP6V1A/RRAGA/NAGA/LAMTOR2/BORCS7/ATP6AP1/LAMTOR5/AGA/ARL8A/LAMTOR1/ATP6V0B/LIPA/PLEKHM1/SCARB2/CLTB/VPS26A/HEXB/BLOC1S2/IGF2R/ATP6V0C/ENTPD4/VPS29/CTSO/LAMTOR4/KXD1/ACP2/ATP6V1E1/ATP6V1G1/VAMP7/CLN5/AP3M1/RRAGC/CD68/AP5M1/ACP5/RRAGB/GNPTG/SNAPIN/CLN3/TFEB/SLC15A4/MTOR/AP2S1/CLN8/CTSF/HYAL1/NCOA7/AP1S1/CTSL/OSBPL1A/LAMP3/GM2A/LAPTM4A/BORCS6/AP4B1/TMEM175/TTI1/OSBPL7/ATP6V1B2/SLC29A1/MCOLN3/ATP6V0A2/AP3M2/PPT2/GPR155/MFSD8/ATP6V0E1/CLN6/TELO2	5.01876101398415
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	56/1775	163/9376	1.81476194590858	CREB5/NFATC1/NFATC2/PIK3R3/MMP9/CDKN1A/TGFBR1/TICAM1/IRF7/KRAS/MAP2K3/EGR3/IFIH1/SMAD3/CREB1/ATP6AP1/MAPK14/BAX/HSPG2/IL6/IFNAR1/RELA/MAPK3/STAT5A/CYCS/MAP2K4/SMAD4/NRAS/MYD88/SOS2/MYC/TRAF6/MAPK12/MAPK8/MAP3K1/TYK2/CHUK/SOS1/AKT3/IRAK1/ARAF/ELK1/HRAS/DDB2/ATF6B/CDK2/IKBKG/PCNA/TIRAP/NFKBIA/TGFB2/TGFB3/BRAF/EGR2/PTK2B/JAK1	5.0707646492422
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/1775	119/9376	1.95310214226536	ICAM1/CCL2/CREB5/JAG1/EDN1/PIK3R3/MMP9/CXCL2/BCL3/SELE/MAP2K3/TNFRSF1A/RPS6KA5/CXCL3/MAP3K8/CFLAR/CREB1/DAB2IP/TNFAIP3/TNFRSF1B/MAPK14/SOCS3/IL6/RELA/MAPK3/MLKL/MAP2K4/MAPK12/MAPK8/JUNB/FRMD8/CHUK/CSF1/AKT3/ATF6B/IL18R1/IKBKG/MAP3K14/BIRC3/NFKBIA/RHBDF1/CX3CL1/BAG4/RHBDF2	5.0562349370951
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	30/1775	71/9376	2.23193810751835	CXCL2/HBEGF/ATP6V1F/F11R/JAM2/CXCL3/NOD1/ATP6V1A/GIT1/RAC1/ATP6AP1/MAPK14/ATP6V0B/RELA/MAP2K4/ATP6V0C/ATP6V1E1/PLCG2/ATP6V1G1/MAPK12/MAPK8/MET/CHUK/JAM3/IKBKG/MAP3K14/NFKBIA/ATP6V1B2/ATP6V0A2/ATP6V0E1	5.03511420691968
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	34/1775	87/9376	2.06432896227942	LEF1/PIK3R3/CDKN1A/PMAIP1/TGFBR1/KRAS/RALGDS/SMAD3/RAC1/SMAD2/BAX/MAPK3/CYCS/AXIN2/SMAD4/NRAS/SOS2/MYC/MAPK8/RALA/SOS1/AKT3/MTOR/ARAF/POLK/HRAS/DDB2/GADD45B/TGFB2/TGFB3/AXIN1/BRAF/RPS6KB2/BBC3	4.8194832556018
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	103/1775	368/9376	1.47845682792407	TUBB6/NXT1/ADRM1/NDUFB4/MAP2K3/NDUFC1/ANXA11/NDUFC2/NUP54/PINK1/TNFRSF1A/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/NDUFA8/RAC1/PSMD7/TNFRSF1B/EIF2S1/COX5A/KLC1/NDUFS7/COX7A1/MAPK14/BAX/NDUFS2/NDUFA7/ATG2B/COX5B/ACTR1A/CYCS/COX6A1/NDUFS6/PSMB2/NDUFA3/UQCR11/TUBB2A/COX6B1/NDUFA2/SDHD/UQCRQ/PFN1/ATXN2L/PSMC6/BCL2L1/UQCRH/NDUFAB1/UBQLN1/NUP50/ATP5MC1/GPX7/COX7C/ACTR10/UQCR10/PSMB6/MAPK12/NDUFB11/ATG101/ATP5MC2/RANBP2/DCTN6/PSMD6/ATP5PD/CASP1/VCP/TPR/NUP160/ALYREF/NDUFA13/COX7B/TUBA1A/CYC1/ATF6/ATP5PF/RAE1/ALS2/UQCRB/PSMA2/MTOR/SEH1L/NUP88/NDUFB2/SETX/TUBA4A/MT-ND4/PIK3R4/TUBA1B/C9orf72/MT-CO2/NDUFA4/SIGMAR1/SLC1A2/UQCRC1/NUP35/PSMA7/MT-ND3/MT-ND1/DNAL1/MT-ND2	4.52482646460102
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	69/1775	224/9376	1.62712273641851	ZFP36/ICAM1/CREB5/NFATC1/NFATC2/HLA-C/PIK3R3/MSX1/FOSL1/ADCY4/CDKN1A/CDC26/TGFBR1/ETS1/KRAS/TNFRSF1A/SLC25A5/RANBP1/SMAD3/ANAPC16/ETS2/HLA-F/HLA-A/CREB1/SMAD2/B2M/HLA-DMA/BAX/IL6/RELA/HLA-E/ELK4/FDPS/BUB3/MAPK3/STAT5A/MAP2K4/SMAD4/MAP3K3/NRAS/BCL2L1/MYC/CCND3/TBPL1/MAPK8/CDKN2C/MAP3K1/HLA-DRB1/CHUK/CANX/AKT3/ELK1/HRAS/HLA-DRB5/CD40/ATF6B/KAT2A/KAT5/CDK2/IKBKG/MAP3K14/TBP/ADCY6/NFKBIA/TGFB2/TGFB3/HLA-B/EGR2/JAK1	4.59058465402899
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	86/1775	300/9376	1.51424600938967	JUND/DUSP5/KDR/DUSP6/NFATC1/ANGPT2/HSPA1B/CDC25B/HSPA1A/EFNA1/DUSP3/FGFR1/GNG12/MAP3K13/NR4A1/MAP3K11/TGFBR1/DUSP1/KRAS/MAP2K3/MAX/TNFRSF1A/RPS6KA5/EPHA2/RPS6KA2/MAP3K8/RASA2/RAC1/RASGRP2/CRK/MAPK14/RASGRF2/RPS6KA3/RELA/ELK4/TAOK2/MAPK3/PDGFB/DUSP8/MAP2K4/MAP3K3/NRAS/MYD88/MKNK2/SOS2/MYC/DUSP10/NLK/TRAF6/MAPK12/MAPK8/MRAS/FLT1/MAP3K1/PPP5C/MET/KITLG/MAPK7/CHUK/FLT4/SOS1/CSF1/AKT3/IRAK1/ARAF/ELK1/IL1RAP/MEF2C/HRAS/RAPGEF2/MAP4K2/IKBKG/MAP3K14/PDGFD/RASGRP3/GADD45B/TGFB2/DUSP7/TGFB3/MECOM/PDGFA/MAP3K6/BRAF/RASGRF1/ECSIT/DUSP4	4.37455382578432
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/1775	275/9376	1.53665556978233	CREB5/TUBB6/HSPA1B/PIK3R3/HSPA1A/CAV2/ADRM1/NDUFB4/NDUFC1/NDUFC2/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NOTCH1/NDUFB3/NDUFA8/CREB1/RAC1/PSMD7/CSNK2B/EIF2S1/COX5A/KLC1/NDUFS7/COX7A1/MAPK14/BAX/NDUFS2/IL6/NDUFA7/COX5B/MAPK3/CYCS/COX6A1/NDUFS6/PSMB2/NDUFA3/UQCR11/TUBB2A/COX6B1/NDUFA2/SDHD/UQCRQ/PSMC6/UQCRH/NDUFAB1/ATP5MC1/COX7C/UQCR10/PSMB6/MAPK12/NDUFB11/ATP5MC2/MAPK8/PSMD6/ATP5PD/NDUFA13/COX7B/TUBA1A/CYC1/ATP5PF/UQCRB/PSMA2/NDUFB2/TUBA4A/RYR2/MT-ND4/TUBA1B/ATF6B/MT-CO2/NDUFA4/UQCRC1/PSMA7/MT-ND3/MT-ND1/MT-ND2	4.36482545601974
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	30/1775	77/9376	2.05802085238705	PIK3R3/CDKN1A/TGFBR1/KRAS/RALGDS/SMAD3/RAC1/SMAD2/RALBP1/BAX/RELA/MAPK3/SMAD4/BCL2L1/MAPK8/RALA/PLD1/CHUK/AKT3/MTOR/ARAF/POLK/DDB2/IKBKG/GADD45B/TGFB2/TGFB3/BRAF/JAK1/RPS6KB2	4.50475230934448
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	126/1775	480/9376	1.38659154929577	TUBB6/CALML4/NOX4/ADRM1/UBE2J1/NDUFB4/KRAS/MAP2K3/NDUFC1/FZD6/NDUFC2/PINK1/TNFRSF1A/SLC25A5/NDUFB9/NDUFA12/ATP5F1C/COX7A2/COX8A/UQCRFS1/NDUFB3/NDUFA8/RAC1/PSMD7/TNFRSF1B/CSNK2B/EIF2S1/COX5A/KLC1/CSNK1E/NDUFS7/COX7A1/MAPK14/BAX/NDUFS2/IL6/RELA/NDUFA7/ATXN3/ATG2B/COX5B/HTT/MAPK3/ACTR1A/CYCS/COX6A1/AXIN2/SNCA/NDUFS6/PSMB2/NDUFA3/UQCR11/TUBB2A/COX6B1/NDUFA2/SDHD/UQCRQ/ATXN2L/PSMC6/NRAS/BCL2L1/UQCRH/NDUFAB1/UBE2G2/ATP5MC1/GPX7/HIP1/COX7C/APP/ACTR10/UQCR10/PSMB6/MAPK12/NDUFB11/ATG101/ATP5MC2/MAPK8/DCTN6/PSMD6/CDK5/ATP5PD/VCP/LRP6/RPS27A/NDUFA13/COX7B/TUBA1A/CYC1/ATF6/ATP5PF/FZD4/CSF1/ALS2/UQCRB/PSMA2/MTOR/WNT2B/ARAF/NDUFB2/TUBA4A/HRAS/RYR2/ATXN1L/WNT6/MT-ND4/PIK3R4/LRP5/CHRNA7/TUBA1B/C9orf72/MT-CO2/NDUFA4/CALM1/SIGMAR1/UBA52/UQCRC1/AXIN1/PSMA7/BRAF/MT-ND3/CAMK2G/CALM2/MT-ND1/GRM5/DNAL1/MT-ND2	4.20169997904016
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	46/1775	138/9376	1.76075117370892	CALML4/PIK3R3/RAPGEF1/KRAS/SHC1/PPP1CA/PRKAA1/PRKAR1A/PPP1CC/CRK/FLOT2/SOCS3/EIF4E/PRKAR2B/MAPK3/PTPN1/PRKCI/CBL/G6PC3/NRAS/INPP5A/MKNK2/SOS2/EIF4EBP1/MAPK8/SHC2/RHEB/PPP1CB/HK1/SOCS4/TRIP10/PPP1R3B/SOS1/PRKAG1/AKT3/MTOR/ARAF/ELK1/HRAS/CALM1/BRAF/CALM2/PRKAB2/PHKA2/RPS6KB2/SH2B2	4.35053479011089
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	46/1775	138/9376	1.76075117370892	CCL2/NFATC1/NFATC2/ARPC5L/ARF6/PIK3R3/TICAM1/MAP2K3/RHOG/PXN/ITGA5/RPS6KA2/RAC1/BCAR1/CRK/MAPK14/SKAP2/IL6/RPS6KA3/RELA/VAV2/MAPK3/MAP2K4/ARPC1A/MYD88/TRAF6/MAPK12/ARPC3/MAPK8/CASP1/ACTR2/PYCARD/CHUK/ARPC1B/AKT3/IRAK1/ROCK2/ACTR3/ARHGEF12/WASF2/IKBKG/LAT/NFKBIA/ARHGEF28/FN1/PTK2B	4.35053479011089
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	47/1775	142/9376	1.74835151755604	MGST2/KLF2/ICAM1/CDH5/CCL2/THBD/KDR/EDN1/CALML4/PIK3R3/MMP9/MGST3/CAV2/SELE/PECAM1/DUSP1/TNFRSF1A/NQO1/SUMO3/ARHGEF2/SUMO1/PRKAA1/RAC1/MAPK14/RELA/PDGFB/MAP2K4/ACVR1/NOS3/MAPK12/MAPK8/MEF2A/MAPK7/CHUK/AKT3/MEF2C/CTSL/IKBKG/CALM1/ACVR2B/PDGFA/SUMO4/CALM2/HSP90B1/GSTM4/SUMO2/BMPR2	4.34214509366469
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	62/1775	205/9376	1.59755960151151	ISG15/ICAM1/IFNAR2/HLA-C/PIK3R3/CDKN1A/ADRM1/IRF7/MAP2K3/CD58/ENTPD1/HLA-F/HLA-A/RAC1/OAS2/PSMD7/TNFAIP3/B2M/HLA-DMA/MAPK14/BAX/IL6/IFNAR1/TAPBPL/RELA/HLA-E/CYCS/NEDD4/MAP2K4/SIN3A/HDAC1/PSMC6/MYD88/MYC/CCND3/TRAF6/IRF9/PLCG2/MAPK12/MAPK8/PSMD6/HDAC2/HLA-DRB1/TYK2/OAS3/CHUK/AKT3/IRAK1/POLK/HLA-DRB5/DDB2/CD40/CDK2/IKBKG/MAP3K14/NFKBIE/GADD45B/NFKBIA/TAP2/OAS1/HLA-B/JAK1	4.18022119965029
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	40/1775	120/9376	1.76075117370892	CALML4/PIK3R3/RAPGEF1/KRAS/SH2B3/RPS6KA5/RPS6KA2/SHC1/ARHGDIA/RAC1/CRK/MAPK14/BAX/RPS6KA3/RELA/ARHGDIB/MAPK3/RIPK2/MAP3K3/IRAK3/NRAS/SOS2/TRAF6/PLCG2/MAPK12/MAPK8/SHC2/MAP3K1/MAPK7/SOS1/AKT3/IRAK1/HRAS/CALM1/NFKBIE/NFKBIA/BRAF/CAMK2G/CALM2/SH2B2	4.05294800044167
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	49/1775	157/9376	1.64860141742173	IGFBP3/NFATC1/NFATC2/HLA-C/CALML4/PIK3R3/CDKN1A/TGFBR1/ETS1/KRAS/MAP2K3/SLC25A5/SMAD3/PPP1CA/HLA-F/HLA-A/HIPK1/PPP1CC/SMAD2/SERPINE1/MAPK14/IL6/E2F4/RELA/HLA-E/MAPK3/ZFP36L1/NRAS/MYC/CCND3/EIF4EBP1/MAPK12/MRAS/RHEB/PPP1CB/AKT3/MTOR/HRAS/HIPK3/ZFP36L2/CDK2/CALM1/GADD45B/TGFB2/TGFB3/HLA-B/CALM2/E2F5/LIN37	3.96036544702352
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	30/1775	83/9376	1.90924826064823	CBX4/PCGF2/MAX/SCML1/CSNK2B/SUZ12/RYBP/UBE2D2/YAF2/FOXK1/HDAC1/DCAF7/E2F6/TFDP1/HDAC2/YY1/RING1/PCGF3/FBRS/HCFC1/MBD6/ASXL2/PHC1/TEX10/FBRSL1/BAP1/L3MBTL3/UBE2D4/WDR5/PCGF1	4.02061980116835
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	49/1775	158/9376	1.63816723123551	SGK1/SLC3A2/PIK3R3/ATP6V1F/KRAS/FZD6/TNFRSF1A/RPS6KA2/ATP6V1A/RRAGA/LAMTOR2/PRKAA1/LAMTOR5/LAMTOR1/GRB10/RPS6KA3/EIF4E/MAPK3/NRAS/CASTOR1/SOS2/FNIP2/LAMTOR4/EIF4EBP1/ATP6V1E1/ATP6V1G1/LRP6/RHEB/RRAGC/PRR5/RRAGB/FZD4/CHUK/SOS1/AKT3/MTOR/SEH1L/WNT2B/HRAS/WNT6/LRP5/NPRL3/TTI1/STRADB/ATP6V1B2/BRAF/STRADA/RPS6KB2/TELO2	3.90925627889608
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	59/1775	200/9376	1.55826478873239	CLDN5/TUBB6/ARPC5L/ARF6/MYO1D/NCKAP1/GNA13/TNFRSF1A/ARHGEF2/RAC1/TNFSF10/CYTH2/TMBIM6/MAPK14/BAX/IL6/MYO1B/RELA/MAPK3/CYCS/SEC24B/TNFRSF10A/TUBB2A/ARPC1A/TNFRSF10B/MYD88/TRAF6/MAPK12/ARPC3/MAPK8/BRK1/CASP1/MYO6/HCLS1/CLDN15/CYTH3/ACTR2/TUBA1A/PYCARD/CHUK/CYTH1/ARPC1B/IRAK1/TUBA4A/ROCK2/ACTR3/ARHGEF12/NCK2/TUBA1B/WASF2/IKBKG/MYO1E/TIRAP/NFKBIA/GAPDH/CLDN10/CLDN3/TLR5/CLDN23	3.85636366816071
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/1775	99/9376	1.81410726988192	JAG1/JAG2/PIK3R3/MMP9/ADCY4/CDKN1A/HBEGF/NOTCH4/KRAS/SHC1/NOTCH1/MAPK14/BAX/MAPK3/NRAS/SOS2/SP1/MAPK12/MAPK8/CDKN2C/SHC2/ESR2/SOS1/AKT3/MTOR/ARAF/HRAS/DLL1/GPER1/ADCY6/BRAF/DLL4/RPS6KB2/GNAS	3.93500150309977
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	71/1775	253/9376	1.48237154150198	ARPC5L/ARF6/PIK3R3/BCL10/TIFA/RBX1/TNFRSF1A/RPS6KA5/PXN/ITGA5/NOD1/RRAGA/ARHGEF2/RAC1/UBE2N/BCAR1/CAPNS1/CYTH2/CRK/MAPK14/BAX/RELA/ACTN4/RBCK1/MAPK3/CYCS/UBE2D2/MYL12A/RIPK2/DIAPH1/PFN1/ARPC1A/BCL2L1/MYD88/TRAF6/PLCG2/MAPK12/ARPC3/MAPK8/CUL1/CASP1/RPS27A/MALT1/PRKCE/HCLS1/RRAGC/HK1/CYTH3/UBE2V2/UBE2V1/SEPTIN8/ACTR2/RRAGB/PYCARD/CHUK/CYTH1/U2AF1/ARPC1B/AKT3/MTOR/PIK3R4/ROCK2/ACTR3/WASF2/IKBKG/NFKBIA/FNBP1L/UBA52/TLR5/RPS6KB2/UBE2D4	3.75856920878283
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	48/1775	156/9376	1.62530877573131	YWHAH/CLDN5/IFNAR2/PIK3R3/CDKN1A/LDLR/TICAM1/IRF7/KRAS/PPP2R1A/YWHAG/TNFRSF1A/CFLAR/PPP2R1B/OAS2/EIF2S1/SOCS3/BAX/MX1/IFNAR1/RELA/MAPK3/CYCS/NRAS/SOS2/MYC/TRAF6/IRF9/RSAD2/PPP2R2A/CLDN15/TYK2/OAS3/CHUK/SOS1/IFIT1/AKT3/ARAF/HRAS/CDK2/IKBKG/NFKBIA/OAS1/BRAF/CLDN10/CLDN3/JAK1/CLDN23	3.80575488053297
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	89/1775	333/9376	1.41177346360445	ISG15/CREB5/BCAP31/ITGA6/JAG1/IFNAR2/HLA-C/PIK3R3/CDKN1A/NOTCH4/TICAM1/ATP6V1F/KRAS/LAMA5/PPP2R1A/FZD6/ITGA2/VWF/TNFRSF1A/PXN/ITGA5/NOTCH1/ATP6V1A/PPP2R1B/HLA-F/HLA-A/CREB1/ATP6AP1/THBS1/ITGA1/HES4/BAX/ATP6V0B/MX1/IFNAR1/RELA/HLA-E/PPP2R3C/MAPK3/AXIN2/ITGA3/PRKCI/ATP6V0C/HDAC1/NRAS/SOS2/CCND3/EIF4EBP1/IRF9/TBPL1/ATP6V1E1/ATP6V1G1/PKM/LAMB2/UBR4/HDAC2/RHEB/MFNG/PPP2R2A/TYK2/FZD4/CHUK/SOS1/AKT3/MTOR/WNT2B/LFNG/TUBG1/HRAS/WNT6/PPP2R5B/ITGA8/ITGB4/CDK2/IKBKG/TBP/ATP6V1B2/AXIN1/ATP6V0A2/VTN/HLA-B/ATP6V0E1/FN1/SCRIB/JAK1/HEY1/LAMC2/RPS6KB2/GNAS	3.69720607017562
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/1775	173/9376	1.58772938207278	ICAM1/CCL2/IFNAR2/NXT1/PIK3R3/TICAM1/IRF7/TNFRSF1A/SLC25A5/KPNA1/IFIH1/OAS2/TNFSF10/EIF2S1/HLA-DMA/SOCS3/BAX/IL6/MX1/IFNAR1/IL33/RELA/RAB11B/FDPS/MAPK3/CYCS/ADAR/IFNGR1/TNFRSF10A/PABPN1/TNFRSF10B/MYD88/CCND3/IRF9/RSAD2/CASP1/HLA-DRB1/PML/TYK2/OAS3/PYCARD/CHUK/RAE1/AKT3/DNAJB1/HLA-DRB5/RAB11A/IKBKG/NFKBIA/PRSS3/OAS1/JAK1	3.77038061528884
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	37/1775	112/9376	1.74503018108652	LY96/ITGA6/HSPA1B/HSPA1A/GNAI2/LDLR/IL10RB/LAMA5/MAP2K3/TNFRSF1A/HLA-DMA/MAPK14/RELA/MAPK3/CYCS/IFNGR1/BCL2L1/MYD88/TRAF6/LAMB2/MAPK12/MAPK8/HLA-DRB1/GNAI3/TYK2/CHUK/AKT3/IRAK1/HLA-DRB5/CD40/IKBKG/BIRC3/NFKBIA/TGFB2/TGFB3/JAK1/LAMC2	3.83294912698373
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	62/1775	216/9376	1.51620239958268	APOA1/ICAM1/LY96/CCL2/NFATC1/NFATC2/HSPA1B/CALML4/PIK3R3/HSPA1A/MMP9/CXCL2/SELE/LDLR/TICAM1/IRF7/KRAS/MAP2K3/TNFRSF1A/CXCL3/RAC1/ERO1A/TNFSF10/EIF2S1/ABCG1/MAPK14/BAX/IL6/RELA/VAV2/MAPK3/CYCS/MIB1/TNFRSF10A/MAP2K4/NRAS/BCL2L1/TNFRSF10B/MYD88/TRAF6/NOS3/MAPK12/MAPK8/HSPA2/CASP1/ATF6/PYCARD/CHUK/AKT3/IRAK1/HRAS/ROCK2/CD40/IKBKG/TIRAP/CALM1/NFKBIA/RXRB/MMP1/CAMK2G/CALM2/HSP90B1	3.70892975752914
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	46/1775	149/9376	1.63076283202571	FCER1A/ARF6/PIK3R3/PLPP2/RAPGEF4/ADCY4/KRAS/GNA13/RALGDS/SHC1/CYTH2/DNM3/PLPP3/DGKZ/LPAR6/MAPK3/DGKD/PDGFB/AGPAT1/AGPAT4/NRAS/SOS2/DGKH/PLCG2/MRAS/SHC2/RALA/RHEB/PLD1/CYTH3/KITLG/SOS1/CYTH1/AGPAT2/AKT3/MTOR/HRAS/RAPGEF3/PDGFD/ADCY6/AVPR2/PDGFA/GRM2/PTK2B/GRM5/GNAS	3.7504071584768
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	51/1775	170/9376	1.58467605633803	CLDN5/ARPC5L/SYNPO/AFDN/MSN/F11R/JAM2/PPP2R1A/AMOTL2/ARHGEF2/PPP2R1B/PRKAA1/RAC1/CGNL1/MPDZ/ACTN4/MYL12A/PRKCI/NEDD4/ARHGAP17/TJP2/ARPC1A/ARPC3/MAPK8/YBX3/NEDD4L/MAP3K1/PRKCE/PPP2R2A/HCLS1/AMOTL1/CLDN15/ACTR2/TUBA1A/RAPGEF6/PRKAG1/ARPC1B/JAM3/TUBA4A/ROCK2/RAPGEF2/ACTR3/TUBA1B/PCNA/RAB13/TJAP1/CLDN10/CLDN3/SCRIB/PRKAB2/CLDN23	3.71752360656996
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	57/1775	196/9376	1.53616556481748	ZFP36/ICAM1/LEF1/NFATC1/NFATC2/ANGPT2/IFNAR2/HLA-C/CALML4/PIK3R3/CXCL2/CDKN1A/GNG5/GNG12/TICAM1/IRF7/KRAS/TNFRSF1A/CXCL3/GNG10/HLA-F/GNG11/HLA-A/CREB1/RAC1/MAPK14/BAX/IL6/IFNAR1/GNB4/RELA/HLA-E/MAPK3/CYCS/PDGFB/IFNGR1/MAP2K4/NRAS/MYC/IRF9/PLCG2/MAPK12/MAPK8/RPS27A/TYK2/CHUK/PREX1/AKT3/MTOR/HRAS/IKBKG/CALM1/NFKBIA/UBA52/HLA-B/CALM2/JAK1	3.66568433601176
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	61/1775	214/9376	1.50568908779781	BST2/TRIM5/AP1S2/NFATC1/NFATC2/HLA-C/CALML4/PIK3R3/GNAI2/GNG5/GNG12/KRAS/MAP2K3/RBX1/TNFRSF1A/PXN/GNG10/HLA-F/GNG11/HLA-A/RAC1/TNFRSF1B/B2M/CRK/MAPK14/BAX/GNB4/TAPBPL/RELA/HLA-E/MAPK3/CYCS/NRAS/BCL2L1/MYD88/TRAF6/PLCG2/MAPK12/MAPK8/CUL1/RNF7/GNAI3/CHUK/PAK4/DCAF1/WEE1/AKT3/MTOR/IRAK1/ELOC/HRAS/AP1S1/IKBKG/CALM1/NFKBIA/TAP2/CFL1/HLA-B/CALM2/PTK2B/RPS6KB2	3.6161361677778
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	64/1775	227/9376	1.48926971520754	CCL2/CREB5/NFATC1/NFATC2/HLA-C/CALML4/PIK3R3/ADCY4/GNAI2/CDKN1A/GNG5/GNG12/IL10RB/KRAS/GNA13/TNFRSF1A/PXN/GNG10/HLA-F/GNG11/HLA-A/CREB1/RAC1/BCAR1/B2M/CRK/MAPK14/BAX/IL6/GNB4/TAPBPL/RELA/HLA-E/MAPK3/CYCS/NRAS/SOS2/SP1/MYC/EIF4EBP1/MAPK12/RHEB/GNAI3/CHUK/SOS1/AKT3/MTOR/ELK1/HRAS/ROCK2/ARHGEF12/ATF6B/IKBKG/ADCY6/CALM1/NFKBIA/TAP2/HLA-B/CX3CL1/CALM2/PTK2B/JAK1/RPS6KB2/GNAS	3.60598486921685
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	43/1775	140/9376	1.62240643863179	KLF2/JAG1/CALML4/ADCY4/GNAI2/GNG5/GNG12/TGFBR1/KRAS/CCN2/GNA13/GNG10/SMAD3/MYLK/GNG11/PRKAA1/SMAD2/SERPINE1/MEF2D/GNB4/MAPK3/TFAM/SMAD4/NRAS/NOS3/MRAS/GNAI3/PRKCE/MEF2A/HDAC5/PRKAG1/AKT3/MTOR/MEF2C/HRAS/RYR2/PIK3R4/ADCY6/CALM1/CALM2/PRKAB2/RPS6KB2/PLIN1	3.58546578908617
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	47/1775	157/9376	1.58131156364941	ID1/YWHAH/LEF1/RASSF1/TGFBR1/MOB1A/PPP2R1A/FZD6/CCN2/YWHAG/TEAD4/BMP6/SMAD3/PPP2R1B/PPP1CA/PPP1CC/SMAD2/SERPINE1/CSNK1E/AXIN2/SMAD1/PRKCI/SMAD4/FRMD6/TEAD2/MYC/CCND3/SAV1/WTIP/PPP2R2A/PPP1CB/CTNNA1/FZD4/WWTR1/WNT2B/WNT6/BIRC3/TGFB2/BMP2/TGFB3/AXIN1/NKD1/SCRIB/CRB2/BMPR2/AJUBA/BBC3	3.54949306121455
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/1775	37/9376	2.28421773886563	LEF1/CDKN1A/KRAS/BAX/MAPK3/NRAS/TPM3/MYC/TFG/TPR/POLK/HRAS/DDB2/GADD45B/RXRB/BRAF	3.78215035287662
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/1775	34/9376	2.33040596520298	NR1D2/PER1/BHLHE40/CRY2/RBX1/NR1D1/PER3/CREB1/PRKAA1/PER2/CSNK1E/CUL1/FBXL3/PRKAG1/PRKAB2	3.75537370607527
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1775	101/9376	1.7258848138335	ICAM1/CCL2/THBD/NFATC1/EDN1/PIK3R3/NOX4/SELE/TGFBR1/KRAS/SMAD3/RAC1/SMAD2/SERPINE1/MAPK14/BAX/IL6/RELA/MAPK3/STAT5A/DIAPH1/SMAD4/NRAS/PLCG2/NOS3/MAPK12/MAPK8/PRKCE/AKT3/HRAS/TGFB2/TGFB3/FN1	3.54422177151418
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/1775	105/9376	1.71044399731724	GABARAPL2/KRAS/CCZ1B/PINK1/FIS1/TBC1D15/CSNK2B/EIF2S1/SIAH1/FKBP8/RELA/MON1B/CCZ1/SMURF2/SMURF1/PHB2/NRAS/BCL2L1/SP1/OPA1/MAPK8/MRAS/MTX2/VCP/SAMM50/RPS27A/TFEB/GABARAP/FUNDC1/HRAS/TOMM20/UBA52/RHOT2/ATG9A	3.53761575008061
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	25/1775	70/9376	1.88651911468813	PIK3R3/CDKN1A/ETS1/RAPGEF1/KRAS/RBX1/RAC1/EGLN2/CRK/MAPK3/PDGFB/NRAS/SOS2/EPAS1/PRCC/MET/PAK4/SOS1/AKT3/ARAF/ELOC/HRAS/TGFB2/TGFB3/BRAF	3.59753518877894
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	43/1775	142/9376	1.59955564372148	UBE2J1/CDC26/RBX1/UBA6/UBE2Q1/ANAPC16/UBE2A/UBE2N/SIAH1/SOCS3/UBE2D2/UBE2E3/SMURF2/UBE3C/SMURF1/CBL/NEDD4/UBE2G2/CDC34/UBE4B/TRAF6/HERC1/WWP1/PIAS3/CUL1/UBA3/RNF7/NEDD4L/MAP3K1/PML/RPS27A/PRPF19/ELOC/UBE2B/UBE2H/DDB2/BIRC3/KLHL9/UBA52/SYVN1/RHOBTB2/UBE2QL1/UBE2D4	3.47878976081486
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1775	31/9376	2.3855338482508	SEC11C/GET1/SRP19/BAG6/SPCS1/OXA1L/SPCS3/SRP9/SEC61G/SEC62/GET3/SEC11A/IMMP1L/SRP14	3.73385788906292
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	29/1775	86/9376	1.781225024566	ABL2/PIK3R3/CDKN1A/HBEGF/KRAS/SHC1/CRK/MAPK3/STAT5A/CBL/MAP2K4/NRAS/SOS2/MYC/EIF4EBP1/PLCG2/MAPK8/SHC2/PAK4/SOS1/AKT3/MTOR/ARAF/ELK1/HRAS/NCK2/BRAF/CAMK2G/RPS6KB2	3.51695624817301
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	65/1775	238/9376	1.44263226417327	KDR/ANGPT2/ABL2/ARF6/CALML4/PIK3R3/EFNA1/GNG5/FGFR1/RASSF1/GNG12/RGL1/ETS1/AFDN/KRAS/RALGDS/EPHA2/SHC1/GNG10/ETS2/RASA2/GNG11/RAC1/RASGRP2/RALBP1/RASGRF2/GNB4/RELA/RGL2/MAPK3/PDGFB/RALGAPB/NRAS/BCL2L1/SOS2/PLCG2/MAPK8/SHOC2/MRAS/PLA1A/SHC2/FLT1/EXOC2/RALA/PLD1/MET/KITLG/CHUK/FLT4/PAK4/SOS1/CSF1/RAPGEF5/AKT3/ELK1/HRAS/IKBKG/PDGFD/RASGRP3/CALM1/LAT/RIN1/PDGFA/RASGRF1/CALM2	3.34237688716674
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	24/1775	68/9376	1.86432477216239	LEF1/DUSP6/PIK3R3/KRAS/PER2/RELA/MAPK3/STAT5A/RARA/NRAS/SOS2/JUP/MYC/EIF4EBP1/PML/CHUK/SOS1/AKT3/MTOR/ARAF/HRAS/IKBKG/BRAF/RPS6KB2	3.45662829024988
Human Diseases	Cancer: specific types	hsa05214	Glioma	26/1775	76/9376	1.80708673091179	CALML4/PIK3R3/CDKN1A/KRAS/SHC1/BAX/MAPK3/PDGFB/CAMK1D/NRAS/SOS2/PLCG2/SHC2/SOS1/AKT3/MTOR/ARAF/POLK/HRAS/DDB2/CALM1/GADD45B/PDGFA/BRAF/CAMK2G/CALM2	3.41377567702527
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/1775	108/9376	1.66293166405842	RBM8A/IPO11/NXT1/MAGOH/KPNA4/NUP54/KPNA1/SUMO3/SUMO1/NUP42/KPNA3/XPO6/NUP50/UPF3A/TNPO1/DDX19B/IPO7/PNN/UPF3B/RANBP2/SAP18/TMEM33/TPR/NUP160/ALYREF/RAE1/SEH1L/NUP88/PYM1/TNPO2/XPOT/NUP35/SUMO4/SUMO2	3.34839803838413
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	38/1775	125/9376	1.60580507042254	S1PR1/FCER1A/PIK3R3/GNAI2/KRAS/PPP2R1A/ASAH1/CTSD/GNA13/TNFRSF1A/PPP2R1B/RAC1/SGMS1/MAPK14/BAX/RELA/ORMDL2/NSMAF/PPP2R3C/MAPK3/DEGS1/SPTLC1/NRAS/CERS2/NOS3/MAPK12/MAPK8/ABCC1/GNAI3/PRKCE/PPP2R2A/PLD1/AKT3/HRAS/ROCK2/PPP2R5B/SGPL1/SGMS2	3.2949059349388
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	58/1775	212/9376	1.44514483125166	ID1/KDR/ANGPT2/CALML4/PIK3R3/RAPGEF4/ADCY4/GNAI2/EFNA1/FGFR1/PRKD3/AFDN/RAPGEF1/KRAS/MAP2K3/RALGDS/EPHA2/RAC1/RASGRP2/THBS1/BCAR1/PRKD2/EVL/CRK/MAPK14/VAV2/MAPK3/PDGFB/ARAP3/PRKCI/PFN1/NRAS/MAPK12/PRKD1/MRAS/FLT1/RALA/GNAI3/MET/KITLG/FLT4/CSF1/RAPGEF6/RAPGEF5/AKT3/SIPA1/HRAS/RAPGEF2/RAPGEF3/PDGFD/RASGRP3/ADCY6/CALM1/LAT/PDGFA/BRAF/CALM2/GNAS	3.16793437051448
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	26/1775	78/9376	1.76075117370892	ARPC5L/PIK3R3/CAV2/RHOG/PXN/ITGA5/SHC1/CD2AP/RAC1/BCAR1/DNM3/CRK/CLTB/CBL/ARPC1A/ARPC3/SHC2/HCLS1/MET/CTNNA1/SEPTIN8/ACTR2/ARPC1B/ACTR3/WASF2/FN1	3.26020277034174
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	49/1775	174/9376	1.48753116399547	TUSC3/BCAP31/HSPA1B/HSPA1A/RPN1/UBE2J1/TRAM1/KRTCAP2/RBX1/NSFL1C/BCAP29/RPN2/PLAA/NPLOC4/SVIP/DAD1/SELENOS/ERO1A/MAGT1/DNAJB11/EIF2S1/BAX/ATXN3/SSR1/UBE2D2/SEC24B/STT3B/SEC61G/UBQLN1/ERP29/UBE2G2/SEC62/SSR4/UBE4B/MAPK8/CUL1/TXNDC5/HYOU1/VCP/PPP1R15A/ATF6/CANX/DNAJB1/ATF6B/YOD1/SYVN1/HSP90B1/MOGS/UBE2D4	3.13678925930697
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1775	59/9376	1.88012413463834	LEF1/PIK3R3/CDKN1A/KRAS/BAX/MAPK3/AXIN2/NRAS/SOS2/MYC/CTNNA1/SOS1/AKT3/ARAF/ELK1/POLK/HRAS/DDB2/GADD45B/AXIN1/BRAF	3.27703695570036
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	32/1775	103/9376	1.64108847258307	CCL2/PIK3R3/GNAI2/TGFBR1/TICAM1/PPP2R1A/TNFRSF1A/CFLAR/PPP2R1B/SMAD2/SERPINE1/MAPK14/IL6/RELA/MAPK3/IFNGR1/MAP2K4/MYD88/TRAF6/MAPK12/MAPK8/GNAI3/PPP2R2A/CHUK/AKT3/IRAK1/IKBKG/ACE/NFKBIA/TGFB2/TGFB3/GNAS	3.16137417307779
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	20/1775	56/9376	1.88651911468813	TUSC3/MGAT4A/RPN1/KRTCAP2/B4GALT3/RPN2/DAD1/MAGT1/DPM3/ALG5/STT3B/MGAT4B/MGAT5/SRD5A3/ALG2/DOLK/ALG3/MAN2A2/ALG8/MOGS	3.21531563268828
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	39/1775	133/9376	1.54893148363867	KLF2/S1PR1/SGK1/PLK3/PIK3R3/CDKN1A/GABARAPL2/TGFBR1/KRAS/PRMT1/SMAD3/PRKAA1/TNFSF10/CSNK1E/MAPK14/IL6/MAPK3/SMAD4/G6PC3/NRAS/SOS2/NLK/DEPP1/MAPK12/MAPK8/CHUK/PLK2/SOS1/PRKAG1/AKT3/GABARAP/ARAF/HRAS/CDK2/GADD45B/TGFB2/TGFB3/BRAF/PRKAB2	3.08096620647904
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	55/1775	203/9376	1.43115243183237	EMP1/KDR/ITGA6/PIK3R3/CAV2/EMP2/RAPGEF1/LAMA5/ITGA2/VWF/PXN/ITGA5/SHC1/MYLK/PPP1CA/RAC1/PPP1CC/PARVB/THBS1/BCAR1/ITGA1/CRK/FLNB/VAV2/ACTN4/MAPK3/PDGFB/ITGA3/MYL12A/DIAPH1/SOS2/CCND3/LAMB2/MAPK8/SHC2/FLT1/PPP1CB/MET/FLT4/PAK4/SOS1/AKT3/ELK1/HRAS/ROCK2/ITGA8/ITGB4/PDGFD/BIRC3/PDGFA/VTN/BRAF/RASGRF1/FN1/LAMC2	3.00104572700151
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	26/1775	80/9376	1.7167323943662	KDR/PIK3R3/KRAS/SHC1/BAX/IL6/EIF4E/MAPK3/PDGFB/NRAS/BCL2L1/SOS2/EIF4EBP1/PLCG2/SHC2/MET/SOS1/AKT3/MTOR/ARAF/HRAS/PDGFD/PDGFA/BRAF/JAK1/RPS6KB2	3.11102442238484
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	32/1775	105/9376	1.60982964453387	PLK3/NFATC1/NFATC2/CALML4/PIK3R3/BCL10/BCL3/KRAS/EGR3/MAPK14/IL6/RELA/MAPK3/NRAS/IRF9/PLCG2/MAPK12/MAPK8/MRAS/CASP1/MALT1/PYCARD/CHUK/AKT3/HRAS/ARHGEF12/IKBKG/MAP3K14/CALM1/NFKBIA/CALM2/EGR2	3.03661226432427
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	29/1775	93/9376	1.64715432379222	CDH5/HEG1/ARHGAP29/PTPRB/LEF1/RASIP1/FGFR1/TGFBR1/AFDN/SMAD3/RAC1/CSNK2B/PDCD10/ACTN4/MAPK3/PTPN1/SMURF2/SMURF1/MYL12A/SMAD4/NLK/IQGAP1/MET/CTNNA1/NECTIN2/ROCK2/WASF2/NECTIN3/SNAI1	3.03078135475607
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/1775	62/9376	1.7891503861881	NRARP/JAG1/JAG2/SPEN/NOTCH4/APH1A/NOTCH1/NCSTN/HDAC1/HDAC2/DTX3L/MFNG/LFNG/ATXN1L/DLL1/KAT2A/DTX3/CTBP2/DTX2/DLL4/HEY1	3.01256864740456
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	25/1775	78/9376	1.69302997472012	LSM5/LSM8/LSM3/LSM2/LSM6/C1D/CNOT7/BTG2/DCP1A/CNOT8/TENT4B/DIS3/DHX36/PATL1/PFKL/XRN2/EXOSC4/EXOSC8/DCPS/EXOSC10/PAN3/NUDT16/EXOSC9/EDC4/BTG1	2.96998325023536
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	30/1775	99/9376	1.60068288518993	LYPLA1/PIK3R3/PLPP2/KRAS/RALGDS/RAC1/PLPP3/DGKZ/MAPK3/DGKD/PDGFB/SLC44A4/NRAS/SOS2/SP1/DGKH/EIF4EBP1/MAPK8/RHEB/PLD1/SLC22A4/SOS1/AKT3/MTOR/HRAS/WASF2/CHPT1/PDGFD/PDGFA/RPS6KB2	2.90341106578192
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	34/1775	116/9376	1.54824672170957	ICAM1/CDH5/CLDN5/ESAM/PIK3R3/MMP9/RAPGEF4/GNAI2/PECAM1/AFDN/MSN/F11R/JAM2/PXN/RAC1/BCAR1/MAPK14/VAV2/ACTN4/MYL12A/PLCG2/MAPK12/GNAI3/CLDN15/CTNNA1/SIPA1/JAM3/CD99/ROCK2/RAPGEF3/CLDN10/CLDN3/PTK2B/CLDN23	2.87110447021009
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/1775	29/9376	2.18576007770762	RASSF1/MOB1A/TEAD4/CSNK1E/FRMD6/TEAD2/DCHS1/SAV1/WTIP/WWTR1/FAT4/AJUBA	3.0903605601898
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1775	41/9376	1.93253177602199	MMP9/CDKN1A/HBEGF/RASSF1/KRAS/RPS6KA5/THBS1/MAPK3/NRAS/MYC/DAPK3/ARAF/HRAS/MMP1/BRAF	2.89166419258292
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	28/1775	93/9376	1.59035589883386	ITGA6/PIK3R3/CDKN1A/ZBTB17/LAMA5/ITGA2/MAX/BAX/RELA/CYCS/ITGA3/BCL2L1/TRAF4/MYC/TRAF6/LAMB2/CHUK/AKT3/POLK/DDB2/CDK2/IKBKG/BIRC3/GADD45B/NFKBIA/RXRB/FN1/LAMC2	2.76478049373338
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	41/1775	150/9376	1.44381596244131	LEF1/PIK3R3/CDKN1A/TGFBR1/KRAS/FZD6/SHC1/SMAD3/SMAD2/ABCB1/BAX/MAPK3/AXIN2/SMAD4/NRAS/SOS2/JUP/MYC/SHC2/LRP6/MET/CTNNA1/FZD4/SOS1/AKT3/MTOR/WNT2B/ARAF/POLK/HRAS/WNT6/DDB2/LRP5/CDK2/GADD45B/TGFB2/TGFB3/RXRB/AXIN1/BRAF/RPS6KB2	2.64783716233092
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	38/1775	137/9376	1.46515061169939	IL3RA/PIK3R3/PMAIP1/KRAS/CTSD/LMNA/TNFRSF1A/CFLAR/DAB2IP/TNFSF10/EIF2S1/BAX/RELA/MAPK3/CYCS/TNFRSF10A/NRAS/BCL2L1/TNFRSF10B/CTSO/MAPK8/SPTAN1/TUBA1A/CASP2/CHUK/AKT3/CTSF/TUBA4A/HRAS/TUBA1B/CTSL/IKBKG/MAP3K14/BIRC3/GADD45B/NFKBIA/CSF2RB/BBC3	2.6502744335322
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	27/1775	90/9376	1.58467605633803	NFATC1/NFATC2/PIK3R3/TICAM1/KRAS/MAP2K3/CSNK2B/MAPK14/RELA/MAPK3/IFNGR1/MAP3K3/NRAS/MYD88/TRAF6/MAPK12/CHUK/AKT3/MTOR/HRAS/IKBKG/TIRAP/NFKBIE/LAT/NFKBIA/JAK1/RPS6KB2	2.69321903103011
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	59/1775	232/9376	1.34333171442448	SCIN/RGCC/ITGA6/ARPC5L/PIK3R3/FGFR1/GNG12/MSN/KRAS/ITGA2/NCKAP1/GNA13/PXN/ITGA5/MYLK/PPP1CA/GIT1/RAC1/PPP1CC/BCAR1/ITGA1/CRK/VAV2/ACTN4/ITGAE/MAPK3/PDGFB/ITGA3/MYL12A/DIAPH1/PFN1/ARPC1A/NRAS/SOS2/SSH1/ARPC3/IQGAP1/BRK1/MRAS/PPP1CB/ACTR2/PAK4/SOS1/ARPC1B/AKT3/ARAF/HRAS/ROCK2/ACTR3/ARHGEF12/ITGA8/WASF2/ITGB4/PDGFD/SSH2/CFL1/PDGFA/BRAF/FN1	2.55881717187486
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	22/1775	70/9376	1.66013682092555	LEPR/TNFRSF1A/ADIPOR1/PRKAA1/TNFRSF1B/ACSL5/SOCS3/RELA/G6PC3/ADIPOR2/MAPK8/ACSL3/CHUK/PRKAG1/AKT3/MTOR/IKBKG/NFKBIE/NFKBIA/RXRB/POMC/PRKAB2	2.67886546758081
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	36/1775	130/9376	1.46277789815818	CREB5/EDN1/PIK3R3/MMP9/ADCY4/GNAI2/GNG5/GNG12/TGFBR1/KRAS/SHC1/GNG10/GNG11/CREB1/SMAD2/MAPK14/RXFP1/GNB4/RELA/MAPK3/MAP2K4/NRAS/SOS2/NOS3/MAPK12/MAPK8/SHC2/GNAI3/SOS1/AKT3/HRAS/ATF6B/ADCY6/NFKBIA/MMP1/GNAS	2.56753747712732
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	40/1775	148/9376	1.42763608679102	LEF1/JAG1/JAG2/PIK3R3/CDKN1A/FGFR1/NOTCH4/KRAS/FZD6/SHC1/NOTCH1/BAX/MAPK3/AXIN2/NRAS/SOS2/SP1/MYC/SHC2/LRP6/ESR2/FZD4/FLT4/SOS1/AKT3/MTOR/WNT2B/ARAF/POLK/HRAS/WNT6/DDB2/LRP5/DLL1/GADD45B/AXIN1/BRAF/DLL4/HEY1/RPS6KB2	2.53396645979285
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/1775	109/9376	1.50229228582504	NFATC1/NFATC2/TGFBR1/AHR/SMAD3/SMAD2/HLA-DMA/MAPK14/IL6/RELA/MAPK3/STAT5A/IFNGR1/IL4R/SMAD4/RARA/MAPK12/MAPK8/HLA-DRB1/TYK2/CHUK/MTOR/IL1RAP/HLA-DRB5/IKBKG/NFKBIE/LAT/NFKBIA/IL27RA/RXRB/JAK1	2.54888139006555
NA	NA	hsa04517	IgSF CAM signaling	73/1775	299/9376	1.28964718074332	ICAM1/ICAM2/KDR/PLXNA2/TUBB6/ESAM/ARPC5L/ARF6/PIK3R3/FGFR1/ROBO4/AFDN/MSN/F11R/JAM2/PMP22/EPB41L3/PXN/CASKIN2/ITGA5/CD2AP/MYLK/GIT1/RAC1/BCAR1/SRGAP2/MAPK14/MPDZ/VAV2/ACTN4/MAPK3/MYL12A/PRKCI/TUBB2A/DYNLL2/TJP2/ARPC1A/APP/TRAF6/PLCG2/MAPK12/ARPC3/MAPK8/IQGAP1/SPTAN1/CDH2/SPTBN1/PVR/INPP5D/SRGAP1/ACTR2/TUBA1A/PAK4/RAPGEF6/NECTIN2/ARPC1B/AKT3/UNC5B/SCN8A/JAM3/IL1RAP/TRIO/TUBA4A/RAPGEF2/ACTR3/NCK2/TUBA1B/NECTIN3/DYNLL1/MPP3/CADM3/ROBO3/EPB41L1	2.45970589941608
Human Diseases	Infectious disease: viral	hsa05162	Measles	37/1775	136/9376	1.43708367854184	HSPA1B/IFNAR2/PIK3R3/HSPA1A/IRF7/MSN/IFIH1/OAS2/TNFAIP3/CSNK2B/EIF2S1/BAX/IL6/MX1/IFNAR1/RELA/STAT5A/CYCS/ADAR/BCL2L1/MYD88/CCND3/TRAF6/IRF9/MAPK8/TYK2/OAS3/CHUK/AKT3/IRAK1/CDK2/IKBKG/NFKBIA/CD46/OAS1/JAK1/BBC3	2.48111850975952
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/1775	204/9376	1.34645677989506	KDR/HOXD10/PIK3R3/MMP9/CDKN1A/HBEGF/CAV2/FGFR1/MSN/KRAS/FZD6/ITGA2/PXN/ITGA5/PPP1CA/RAC1/PPP1CC/SMAD2/THBS1/MAPK14/HSPG2/VAV2/MAPK3/CBL/NRAS/SOS2/MYC/PLCG2/MAPK12/IQGAP1/MRAS/HCLS1/PPP1CB/MET/FZD4/SOS1/AKT3/MTOR/WNT2B/ARAF/ELK1/HRAS/WNT6/ROCK2/ARHGEF12/CTSL/TGFB2/VTN/BRAF/CAMK2G/FN1/RPS6KB2	2.41758401731926
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	30/1775	106/9376	1.49497741163965	CREB5/LEF1/FOLH1/PIK3R3/MMP9/CDKN1A/FGFR1/ERG/KRAS/CREB1/RELA/MAPK3/PDGFB/NRAS/SOS2/CHUK/SOS1/AKT3/MTOR/ARAF/HRAS/CDK2/IKBKG/PDGFD/NFKBIA/PDGFA/BRAF/ETV5/HSP90B1/GRM5	2.47655453886386
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/1775	44/9376	1.80076824583867	CREB5/VAMP2/CREB1/ARHGDIA/ARHGDIB/RAB11B/DYNLL2/DYNC1LI2/DCTN6/DYNC1LI1/RAB11A/ADCY6/DYNLL1/AVPR2/GNAS	2.57273625622484
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	44/1775	170/9376	1.36717149958575	MGST2/LEF1/PIK3R3/MGST3/CDKN1A/TGFBR1/KRAS/FZD6/NQO1/SHC1/SMAD3/SMAD2/BAX/MAPK3/AXIN2/SMARCD1/SMAD4/NRAS/BCL2L1/SOS2/MYC/PLCG2/SHC2/LRP6/MET/FZD4/SOS1/AKT3/MTOR/WNT2B/ARAF/ELK1/POLK/HRAS/WNT6/DDB2/LRP5/GADD45B/TGFB2/TGFB3/AXIN1/BRAF/GSTM4/RPS6KB2	2.33457262799311
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	47/1775	184/9376	1.34927127985303	PLXNA2/NFATC2/PIK3R3/RGS3/GNAI2/EFNA1/SEMA3F/SEMA3B/KRAS/EPHA2/EPHB4/RYK/RAC1/SEMA6B/SRGAP2/FES/EPHA4/MAPK3/MYL12A/NRAS/ABLIM2/SSH1/PLCG2/SEMA3A/CDK5/GNAI3/SEMA6A/MET/SRGAP1/PAK4/UNC5B/SEMA3C/HRAS/ROCK2/ARHGEF12/NCK2/EFNB2/SEMA4A/SSH2/SEMA7A/CFL1/ROBO3/CAMK2G/EPHB6/SEMA4C/SEMA6D/BMPR2	2.31215119532723
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1775	78/9376	1.55758757674251	LY96/CALML4/GNAI2/TICAM1/ITGA5/NOD1/MAPK14/IL6/RELA/MAPK3/SERPING1/MYD88/TRAF6/MAPK12/MAPK8/CASP1/GNAI3/PYCARD/IRAK1/TIRAP/CALM1/CFL1/CALM2	2.38954421002261
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	37/1775	139/9376	1.40606748404094	CREB5/HSPA1B/CALML4/PIK3R3/HSPA1A/MMP9/ADCY4/GNAI2/HBEGF/KRAS/KCNJ6/CTSD/SHC1/KRT10/CREB1/KRT18/MAPK3/RARA/NRAS/KRT23/SOS2/SP1/NOS3/SHC2/GNAI3/ESR2/SOS1/AKT3/HRAS/ATF6B/GPER1/ADCY6/CALM1/CALM2/HSP90B1/POMC/GNAS	2.33071726676226
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	33/1775	122/9376	1.42880628030478	IGFBP3/CREB5/PIK3R3/ADCY4/GNAI2/KRAS/MAP2K3/SHC1/CREB1/BCAR1/CRK/MAPK14/SOCS3/MAPK3/STAT5A/MAP2K4/NRAS/SOS2/PLCG2/MAPK12/MAPK8/SHC2/MAP3K1/JUNB/GNAI3/SOS1/AKT3/MTOR/HRAS/ATF6B/GHR/ADCY6/GNAS	2.3036991167664
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	30/1775	109/9376	1.45383124434681	LY96/IFNAR2/PIK3R3/TICAM1/IRF7/MAP2K3/MAP3K8/RAC1/MAPK14/IL6/IFNAR1/RELA/MAPK3/MAP2K4/MYD88/TRAF6/IRF9/MAPK12/MAPK8/TYK2/CHUK/TOLLIP/AKT3/IRAK1/CD40/IKBKG/TIRAP/NFKBIA/JAK1/TLR5	2.30296591365293
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1775	75/9376	1.54946103286385	IGFBP3/SHISA5/EI24/CDKN1A/PMAIP1/THBS1/SERPINE1/SIVA1/SIAH1/BAX/CYCS/TNFRSF10A/CCNG1/BCL2L1/TNFRSF10B/CCND3/SESN3/ZMAT3/DDB2/CDK2/GADD45B/BBC3	2.30861842981384
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	19/1775	63/9376	1.59306058573664	POLR2J/POLR2K/POLE4/RBX1/GTF2H5/POLR2I/POLR2F/POLR2E/POLR2G/CCNH/RPA3/RFC2/DDB2/RFC3/GTF2H3/ERCC4/PCNA/POLR2C/RPA1	2.28230659947402
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	84/1775	362/9376	1.2257162866703	PRL/SGK1/YWHAH/IL3RA/CREB5/KDR/ITGA6/ANGPT2/IFNAR2/PIK3R3/EFNA1/CDKN1A/GNG5/FGFR1/GNG12/NR4A1/KRAS/LAMA5/PPP2R1A/ITGA2/YWHAG/VWF/CDC37/EPHA2/ITGA5/GNG10/PPP2R1B/GNG11/CREB1/PRKAA1/RAC1/THBS1/ITGA1/OSMR/IL6/IFNAR1/LPAR6/GNB4/RELA/EIF4E/PPP2R3C/MAPK3/PDGFB/IL4R/ITGA3/G6PC3/NRAS/BCL2L1/SOS2/MYC/CCND3/EIF4EBP1/NOS3/LAMB2/PHLPP1/FLT1/RHEB/PPP2R2A/MET/KITLG/CHUK/FLT4/SOS1/CSF1/AKT3/MTOR/PKN3/HRAS/PPP2R5B/ATF6B/ITGA8/ITGB4/CDK2/IKBKG/GHR/PDGFD/PHLPP2/PDGFA/VTN/FN1/HSP90B1/JAK1/LAMC2/RPS6KB2	2.11644923495742
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/1775	55/9376	1.63269654289373	PLPP2/ASAH1/UGCG/SGMS1/KDSR/PLPP3/ACER3/HEXB/DEGS1/SPTLC1/CERS2/CERK/B4GALT5/GBA2/GM2A/SGPL1/SGMS2	2.27402378491647
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/1775	51/9376	1.65717757525545	ATP6V1F/ATP6V1A/ATP6AP1/ERO1A/ATP6V0B/SLC12A2/ATP6V0C/TJP2/SEC61G/ATP6V1E1/PLCG2/ATP6V1G1/ATP6V1B2/ATP6V0A2/ATP6V0E1/GNAS	2.2740125339212
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	27/1775	98/9376	1.45531474561656	SCIN/ARPC5L/MARCKSL1/ARF6/PIK3R3/PLPP2/RAC1/CRK/PLPP3/VAV2/MAPK3/ARPC1A/ASAP2/PLCG2/ARPC3/PRKCE/PLD1/ASAP1/INPP5D/ACTR2/ARPC1B/AKT3/ACTR3/WASF2/LAT/CFL1/RPS6KB2	2.18951043724003
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	25/1775	90/9376	1.46729264475743	CREB5/PIK3R3/ADCY4/KRAS/ADIPOR1/CREB1/PRKAA1/BAX/RELA/EIF4E/NRAS/ADIPOR2/EIF4EBP1/ATG101/SESN3/RHEB/PRKAG1/AKT3/MTOR/HRAS/ATF6B/ADCY6/KL/PRKAB2/RPS6KB2	2.15251066001154
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	10/1775	28/9376	1.88651911468813	PTS/PCBD1/MOCS2/GCH1/ALPL/AKR1B1/AKR1C3/FPGS/DHFR/SPR	2.2701639274483
NA	NA	hsa04519	Cadherin signaling	92/1775	404/9376	1.20288941570213	CDH5/YWHAH/LEF1/KDR/ARPC5L/ATN1/FGFR1/MYO1D/AFDN/MOB1A/KRAS/MAP2K3/APH1A/FZD6/NCKAP1/YWHAG/TEAD4/AMOTL2/RYK/KRT10/PPP1CA/PCDH17/RAC1/PPP1CC/DSP/EVL/MAPK14/MYO1B/MPDZ/PCDH11X/KRT18/RELA/VAV2/ACTN4/NCSTN/TAOK2/MAPK3/LHFPL6/AXIN2/TMC6/ARPC1A/TEAD2/NRAS/KRT23/DCHS1/JUP/PCDH7/PCDH1/MAPK12/ARPC3/MAPK8/SHOC2/BRK1/CDH2/MRAS/SAV1/LRP6/WTIP/PPP1CB/CDH12/AMOTL1/MET/CTNNA1/ACTR2/FZD4/CHUK/FLT4/PCDH20/PCDHB10/ARPC1B/PCDH12/WWTR1/WNT2B/FAT4/HRAS/WNT6/TMC7/ROCK2/ACTR3/LRP5/VANGL1/CDH26/IKBKG/MYO1E/NFKBIA/ERBIN/AXIN1/PCDHB2/PTK2B/CDH24/CELSR1/AJUBA	2.01444257748754
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	38/1775	149/9376	1.34715190471689	ADCY4/GNAI2/GNG5/GNG12/NDUFB4/NDUFC1/KCNJ6/NDUFC2/NDUFB9/NDUFA12/GNG10/NDUFB3/NDUFA8/GNG11/NDUFS7/MAPK14/NDUFS2/GNB4/NDUFA7/MAPK3/NDUFS6/NDUFA3/NDUFA2/NDUFAB1/MAPK12/NDUFB11/MAPK8/GNAI3/NDUFA13/NDUFB2/MT-ND4/NDUFA4/ADCY6/MT-ND3/DAGLB/MT-ND1/GRM5/MT-ND2	2.06410543301641
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/1775	44/9376	1.68071702944942	TUSC3/MGAT4A/RPN1/KRTCAP2/B4GALT3/RPN2/DAD1/MAGT1/HEXB/STT3B/MGAT4B/ALG2/ALG3/MAN2A2	2.18703150505177
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	50/1775	205/9376	1.28835451734799	SCIN/YWHAH/CREB5/GTF2A2/HLA-C/PIK3R3/CDKN1A/PMAIP1/IRF7/KRAS/YWHAG/EGR3/PXN/RANBP1/RASA2/HLA-F/HLA-A/CREB1/RAC1/BAX/RELA/HLA-E/ACTN4/MAPK3/STAT5A/HDAC7/HDAC1/NRAS/CCND3/IRF9/TBPL1/PKM/GTF2E2/UBR4/HDAC2/SP100/HDAC5/HRAS/GTF2H3/ATF6B/KAT2A/CDK2/IKBKG/TBP/NFKBIA/HDAC9/HLA-B/EGR2/SCRIB/JAK1	2.01718065174421
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	29/1775	109/9376	1.40537020286859	CREB5/PIK3R3/TNFRSF1A/RPS6KA2/TBC1D4/PPP1CA/CREB1/PRKAA1/PPP1CC/PTPA/SOCS3/IL6/NR1H2/RPS6KA3/RELA/PTPN1/G6PC3/NOS3/MAPK8/PRKCE/PPP1CB/PPP1R3B/PRKAG1/AKT3/MTOR/MLX/NFKBIA/PRKAB2/RPS6KB2	2.05705043724031
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/1775	87/9376	1.45717338513842	ATP1A1/ASPH/COX7A2/COX8A/UQCRFS1/COX5A/COX7A1/COX5B/COX6A1/UQCR11/COX6B1/UQCRQ/UQCRH/TPM3/COX7C/UQCR10/COX7B/CYC1/UQCRB/ATP1B3/RYR2/MT-CO2/SLC9A6/UQCRC1	2.07016773259895
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	46/1775	187/9376	1.29937787150712	CCL2/IFNAR2/CXCL2/GABARAPL2/TICAM1/IRF7/CXCL3/GSDMD/NOD1/OAS2/TNFAIP3/MAPK14/IL6/CARD16/IFNAR1/RELA/RBCK1/MAPK3/RIPK2/BCL2L1/MYD88/CARD6/TRAF6/IRF9/CARD8/MAPK12/MAPK8/TRPV2/NLRP1/CASP1/GBP4/DHX33/TYK2/OAS3/PYCARD/CHUK/GABARAP/NEK7/GPSM3/IKBKG/BIRC3/NFKBIA/ERBIN/OAS1/CAMP/JAK1	1.99827762011027
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	49/1775	201/9376	1.2877135449513	IGFBP3/DUSP6/MMP9/CDKN1A/LMO2/LYL1/ZBTB17/ERG/KLF3/MAX/PER2/CDK9/BAX/MLF1/IL6/RELA/ELK4/HHEX/FLI1/EWSR1/SMAD1/SIN3A/HDAC1/RARA/BCL2L1/SP1/JUP/MYC/KMT2A/HDAC2/CDKN2C/TSPAN7/FLT1/PML/ETV6/PRCC/MET/POLK/MEF2C/DDB2/CD40/ETV1/BIRC3/GADD45B/RXRB/PDGFA/LDB1/SS18L1/ETV5	1.99252945846709
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	28/1775	105/9376	1.40860093896714	ICAM1/LY96/CXCL2/BCL10/TICAM1/TNFRSF1A/CXCL3/CFLAR/TNFAIP3/CSNK2B/RELA/BCL2L1/MYD88/TRAF6/PLCG2/CARD10/MALT1/CHUK/IRAK1/CD40/IKBKG/MAP3K14/TIRAP/BIRC3/LAT/GADD45B/NFKBIA/CCL21	2.03460529281158
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1775	49/9376	1.6170163840184	EOGT/B4GALT3/GALNT2/C1GALT1C1/GALNT18/GALNT4/MFNG/FUT11/GALNT7/GALNT10/LFNG/GALNT15/POFUT2/B3GLCT/GALNT9	2.09253725373041
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1775	33/9376	1.76075117370892	VAMP2/STX3/VAMP5/SNAP23/GOSR2/STX6/USE1/VAMP7/VAMP4/YKT6/BNIP1	2.11546515985271
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1775	93/9376	1.41996062395881	NFATC1/NFATC2/JAG1/JAG2/NOTCH1/HLA-DMA/MAPK14/RELA/MAPK3/STAT5A/IFNGR1/IL4R/MAPK12/MAPK8/HLA-DRB1/TYK2/CHUK/HLA-DRB5/DLL1/IKBKG/NFKBIE/LAT/NFKBIA/JAK1/DLL4	1.96677791066531
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1775	93/9376	1.41996062395881	CALML4/ADCY4/HBEGF/KRAS/MAP2K3/MAPK14/MAPK3/MAP2K4/MAP3K3/NRAS/SOS2/MAPK12/MAPK8/MAP3K1/PLD1/MAPK7/SOS1/ELK1/HRAS/ADCY6/CALM1/CAMK2G/CALM2/PTK2B/GNAS	1.96677791066531
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/1775	18/9376	2.05420970266041	CD320/LMBRD1/THAP11/PRDX1/TCN2/HCFC1/MMAB	2.16332212402577
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	23/1775	85/9376	1.42931565865783	PNP/AK2/CDA/ENTPD1/AK3/NT5C3A/UPP1/AK1/CANT1/DGUOK/NT5C2/NME3/ENTPD4/DCTD/HPRT1/NME1/UCK2/AK6/IMPDH1/RRM1/GMPR2/CMPK2/NUDT16	1.92134083229385
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	36/1775	144/9376	1.32056338028169	ID3/ID1/SMAD9/KLF4/PIK3R3/SKIL/PCGF2/FGFR1/KRAS/FZD6/SMAD3/SMAD2/MAPK14/MAPK3/AXIN2/SMAD1/SMAD4/NRAS/MYC/ACVR1/MAPK12/REST/PCGF3/KAT6A/FZD4/LIFR/AKT3/WNT2B/HRAS/WNT6/ACVR2B/AXIN1/JAK1/ACVR1B/PCGF1/BMPR2	1.8732541688469
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	9/1775	26/9376	1.82847237269772	APOA1/FOLH1/LMBRD1/BTD/ABCC1/TCN2/CUBN/SLC52A3/SLC5A6	2.04412923552944
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1775	122/9376	1.34221196028631	NFATC1/NFATC2/PIK3R3/BCL10/KRAS/PPP2R1A/MAP3K8/PPP2R1B/MAPK14/RELA/VAV2/PPP2R3C/MAPK3/NRAS/SOS2/MAPK12/MAPK8/MALT1/PPP2R2A/CHUK/PAK4/SOS1/AKT3/HRAS/NCK2/PPP2R5B/IKBKG/MAP3K14/NFKBIE/LAT/NFKBIA	1.83848377896456
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/1775	95/9376	1.39006671608599	ICAM1/CCL2/CXCL2/ATP6V1F/CXCL3/ATP6V1A/ATP6AP1/HLA-DMA/ATP6V0B/IL6/ATP6V0C/ATP6V1E1/ATP6V1G1/FLT1/HLA-DRB1/ACP5/CSF1/HLA-DRB5/CTSL/TGFB2/TGFB3/ATP6V1B2/MMP1/ATP6V0A2/ATP6V0E1	1.84651466437325
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	20/1775	73/9376	1.44719274551418	PIK3R3/CDKN1A/RASSF1/KRAS/BAX/MAPK3/STAT5A/NRAS/SOS2/PLCG2/MET/SOS1/AKT3/ARAF/POLK/HRAS/DDB2/GADD45B/RXRB/BRAF	1.85350652782144
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	22/1775	82/9376	1.41718996908279	HSPA1B/HLA-C/HSPA1A/HLA-F/HLA-A/CREB1/B2M/HLA-DMA/TAPBPL/HLA-E/HSPA2/RFXANK/HLA-DRB1/CD74/CANX/HLA-DRB5/CTSL/KLRC3/NFYA/TAP2/RFXAP/HLA-B	1.83353371617696
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	24/1775	91/9376	1.39312180776969	IFITM1/NFATC1/NFATC2/PIK3R3/BCL10/KRAS/RAC1/RELA/VAV2/MAPK3/NRAS/SOS2/PLCG2/MALT1/INPP5D/CHUK/SOS1/AKT3/HRAS/IKBKG/RASGRP3/NFKBIE/NFKBIA/CD79B	1.82098483479247
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	19/1775	69/9376	1.45453357828128	FCER1A/PIK3R3/KRAS/MAP2K3/RAC1/MAPK14/VAV2/MAPK3/MAP2K4/NRAS/SOS2/PLCG2/MAPK12/MAPK8/INPP5D/SOS1/AKT3/HRAS/LAT	1.83119718023583
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	33/1775	133/9376	1.31063433230965	ICAM1/ICAM2/NFATC1/NFATC2/IFNAR2/HLA-C/PIK3R3/KRAS/SHC1/HLA-A/RAC1/TNFSF10/IFNAR1/VAV2/HLA-E/MAPK3/IFNGR1/SH3BP2/TNFRSF10A/NRAS/TNFRSF10B/SOS2/PLCG2/SHC2/SOS1/ARAF/HRAS/KLRC3/LAT/HLA-B/BRAF/ULBP2/PTK2B	1.74348513237796
NA	NA	hsa03272	Virion - Hepatitis viruses	14/1775	48/9376	1.54065727699531	CLDN5/EPCAM/CHMP1B/LDLR/CD9/TGOLN2/HSPG2/PDCD6IP/CHMP1A/CLDN15/CHMP7/CLDN10/CLDN3/CLDN23	1.81467080985172
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/1775	115/9376	1.33204654011023	JUND/SGK1/CREB5/ADCY4/GNAI2/CDKN1A/PDE4D/HBEGF/FGFR1/GNA13/CREB1/MEF2D/MAPK3/NR4A2/SP1/LRP6/GNAI3/PLD1/MEF2A/ARAF/MEF2C/LRP5/ATF6B/ADCY6/KL/RXRB/BRAF/BGLAP/GNAS	1.73128428930191
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	43/1775	181/9376	1.2549000077815	PLK3/CALML4/BCL10/IL10RB/CTSD/TNFRSF1A/CREB1/ATP6AP1/CEBPG/HLA-DMA/MAPK14/BAX/ATP6V0B/IL6/RELA/MAPK3/CYCS/IFNGR1/RIPK2/ATP6V0C/MYD88/TRAF6/MAPK12/MAPK8/RFXANK/HLA-DRB1/MALT1/CD74/AKT3/IRAK1/HLA-DRB5/ARHGEF12/NFYA/TIRAP/CALM1/TGFB2/TGFB3/ATP6V0A2/RFXAP/CAMP/CAMK2G/CALM2/JAK1	1.67333432578226
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/1775	36/9376	1.61402190923318	ST6GALNAC3/GALNT2/C1GALT1C1/GALNT18/GALNT4/B4GALT5/GALNT7/GALNT10/GALNT15/GALNT9/ST6GALNAC1	1.78365612944648
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1775	62/9376	1.44835983643798	HSPA1B/PIK3R3/HSPA1A/ADCY4/KRAS/PRKAA1/HDAC1/NRAS/HDAC2/PRKAG1/AKT3/MTOR/CLPB/HRAS/ADCY6/PRKAB2/RPS6KB2	1.71160631693153
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	19/1775	71/9376	1.41356080142829	PRL/PIK3R3/KRAS/SHC1/MAPK14/SOCS3/RELA/MAPK3/STAT5A/NRAS/SOS2/MAPK12/MAPK8/SHC2/ESR2/SOCS4/SOS1/AKT3/HRAS	1.69028448262824
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1775	28/9376	1.69786720321932	ATP6V1F/SLC12A7/ATP6V1A/ATP6V0C/ATP6V1E1/ATP6V1G1/ATP6V1B2/ATP6V0A2/ATP6V0E1	1.78707139490732
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1775	20/9376	1.84878873239437	LIPA/FDFT1/LBR/SQLE/EBP/MSMO1/DHCR7	1.83619562208323
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	26/1775	103/9376	1.33338438397375	RBM8A/PELO/NXT1/MAGOH/PPP2R1A/CPSF6/PPP2R1B/PPP1CA/PPP1CC/PPP2R3C/NUDT21/PABPN1/SSU72/UPF3A/DDX19B/DAZAP1/PNN/UPF3B/SAP18/PPP2R2A/PPP1CB/ALYREF/SMG5/PYM1/PPP2R5B/CPSF1	1.64400519784027
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	24/1775	94/9376	1.34866047347917	JUND/CCL2/FOSB/MMP9/FOSL1/CXCL2/CXCL3/TNFAIP3/ELAVL1/MAPK14/IL6/RELA/MAPK3/SRSF1/TRAF4/TRAF6/MAPK12/MAPK8/MAPK7/CHUK/IKBKG/NFKBIA/MMP1/HSP90B1	1.64170571860265
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	40/1775	169/9376	1.25023751979332	PIK3R3/GABARAPL2/KRAS/CTSD/RRAGA/CFLAR/PRKAA1/EIF2S1/PLEKHM1/ATG2B/MAPK3/NRAS/BCL2L1/SH3GLB1/RAB33B/TRAF6/ATG101/MAPK8/MRAS/DAPK3/RPS27A/RHEB/RRAGC/WDR45B/RRAGB/VMP1/AKT3/MTOR/GABARAP/UVRAG/HRAS/PIK3R4/C9orf72/CTSL/YKT6/UBA52/GORASP1/ATG9A/ATG4D/RPS6KB2	1.58630304647653
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	45/1775	193/9376	1.23161351528862	CCL14/CCL2/PIK3R3/ADCY4/CXCL2/GNAI2/GNG5/GNG12/KRAS/CXCL3/PXN/SHC1/GNG10/GNG11/RAC1/RASGRP2/BCAR1/CRK/GNB4/RELA/VAV2/CCL23/MAPK3/NRAS/SOS2/PLCG2/SHC2/GNAI3/FGR/XCL2/CHUK/SOS1/GRK5/PREX1/AKT3/HRAS/ROCK2/IKBKG/ADCY6/NFKBIA/CCL21/CCL8/BRAF/CX3CL1/PTK2B	1.57108510438958
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	26/1775	104/9376	1.32056338028169	LYPLA1/PLPP2/PLPP5/SGMS1/CDIPT/PLPP3/DGKZ/DGKD/AGPAT1/AGPAT4/LYPLA2/DGKH/PISD/LCLAT1/PLA1A/PLD1/LPCAT1/AGPAT2/GPAT4/LPCAT2/CRLS1/LPCAT4/CHPT1/CEPT1/CDS1/SGMS2	1.58852230689236
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	34/1775	142/9376	1.26476492759373	JUND/NFATC1/NFATC2/IFNAR2/PIK3R3/FOSB/FOSL1/TGFBR1/TNFRSF1A/CREB1/RAC1/MAPK14/SOCS3/IFNAR1/RELA/MAPK3/IFNGR1/FOSL2/TRAF6/IRF9/PLCG2/MAPK12/MAPK8/JUNB/TYK2/ACP5/CHUK/CSF1/AKT3/IKBKG/MAP3K14/NFKBIA/TGFB2/JAK1	1.53624026190274
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/1775	128/9376	1.27929577464789	PNP/ADCY4/AK2/PDE4D/ENTPD1/AK3/AK1/CANT1/PGM2/DGUOK/NT5C2/NUDT2/PDE9A/NME3/ENTPD4/HPRT1/NME1/PDE8A/AK6/IMPDH1/RRM1/PDE1A/GMPR2/PDE1C/NUDT16/PDE3A/ADCY6/PDE7B/HDDC3/PDE6D/ENPP4	1.53742836860063
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1775	73/9376	1.37483310823847	BST2/TRIM5/FURIN/MDFIC/SERINC3/SUPT4H1/PIN1/CPSF6/CDK9/ELL/MX1/PDCD6IP/MAP1S/RANBP2/PPIA/BICD2/BICD1/KAT2A/HGS	1.55359320993631
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	37/1775	157/9376	1.24486229478784	S1PR1/SGK1/DUSP5/NFATC1/NFATC2/PROS1/SCARF1/PECAM1/ATP11B/UQCRFS1/CREB1/RAC1/ATP11A/THBS1/BCAR1/CRK/MAPK14/LIPA/NR1H2/MAPK3/ATP11C/DUSP8/ARG2/ADAM9/ANO6/MAPK12/ODC1/CASP1/XKR8/ANO5/BSG/DUSP7/TGFBRAP1/CX3CL1/TYRO3/CAMK2G/DUSP4	1.49513113216971
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/1775	69/9376	1.37797917942437	AQP1/REN/ORAI1/EDN1/CALML4/GNAI2/CREB1/GNAI3/KCNMA1/PDE1A/PDE1C/PDE3A/ACE/ADCY6/CALM1/ADRB1/CALM2/GNAS	1.52277948345861
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	37/1775	158/9376	1.23698341950437	YWHAH/CDC25B/CDKN1A/ZBTB17/CDC26/PPP2R1A/RBX1/YWHAG/SMAD3/ANAPC16/PPP2R1B/SMAD2/CDC14A/E2F4/BUB3/MCM3/SMAD4/HDAC1/CCNH/MYC/CDKN1C/CCND3/TFDP1/CUL1/HDAC2/CDKN2C/WEE1/PPP2R5B/CDK2/PCNA/ORC4/GADD45B/TGFB2/TGFB3/DBF4/E2F5/FBXO5	1.45170243056529
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1775	34/9376	1.55360397680199	POLR2J/POLR3GL/POLR2K/POLR2I/POLR2F/POLR2E/POLR2G/POLR3K/POLR2C/POLR3B	1.56267325345591
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/1775	65/9376	1.38151245937161	PLPP2/PLPP5/PNPLA2/PLPP3/DGKZ/DGKD/AGPAT1/DGAT1/AGPAT4/AKR1B1/DGKH/LCLAT1/ALDH2/AGPAT2/GPAT4/AGK/GLYCTK	1.49147744903999
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/1775	56/9376	1.4148893360161	HSPA1B/HSPA1A/CXCL2/CXCL3/HSF1/IL6/RELA/RAB1B/CYCS/MYD88/CASP1/VCP/PYCARD/NFKBIA/TLR5	1.50476187803069
NA	NA	hsa04518	Integrin signaling	36/1775	154/9376	1.23481251143223	ICAM1/ICAM2/KDR/ITGA6/LIMS2/PIK3R3/LAMA5/ITGA2/VWF/PXN/ITGA5/RAC1/PARVB/THBS1/ITGA1/FLNB/ACTN4/ITGAE/PDGFB/ITGA3/CCND3/LAMB2/FLT1/MET/FLT4/AKT3/MTOR/NCK2/ITGA8/ITGB4/PDGFD/PDGFA/VTN/FRAS1/FN1/LAMC2	1.4197716033328
Organismal Systems	Digestive system	hsa04978	Mineral absorption	16/1775	61/9376	1.38550912029554	SLC30A1/ATP1A1/MT1X/MT2A/ATOX1/HMOX2/SLC31A1/ATP2B1/SLC39A4/HEPH/ATP1B3/TRPM6/MT1M/MT1F/ATP7A/ATP7B	1.45967979147074
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	24/1775	98/9376	1.29361310721472	CREB5/ORAI1/ATP1A1/CALML4/ADCY4/NR4A1/PRKD3/LDLR/CREB1/PRKD2/CAMK1D/NR4A2/ATP2B1/PRKD1/PRKCE/ATP1B3/ATF6B/ADCY6/CALM1/DAGLB/CAMK2G/CALM2/POMC/GNAS	1.41192212408269
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1775	10/9376	2.1129014084507	ETHE1/SQOR/SELENBP1/SUOX	1.70148868731201
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1775	89/9376	1.30572558949201	TUBB6/ADCY4/GNAI2/KRAS/MAPK3/PDGFB/TUBB2A/NRAS/SOS2/GNAI3/TUBA1A/MAPK7/SOS1/TUBA4A/HRAS/TUBA1B/PDGFD/ADCY6/PDGFA/ADRB1/GRM5/GNAS	1.40035621191238
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/1775	44/9376	1.44061459667093	GTF2A2/GTF2H5/TAF11/CCNH/TBPL1/GTF2E2/TAF3/TAF6/GTF2H3/TBP/TAF5L/TAF9B	1.41562200270562
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	17/1775	67/9376	1.34027328147992	CALML4/KRAS/RPS6KA2/PPP1CA/PPP1CC/RPS6KA3/MAPK3/NRAS/PPP1CB/ARAF/HRAS/RAPGEF3/CALM1/BRAF/CAMK2G/CALM2/GRM5	1.35071333077378
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1775	27/9376	1.56511215440793	ELOVL1/HACD3/ACOT7/HSD17B12/SCP2/HSD17B4/TECR/HACD2	1.42096506581878
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1775	72/9376	1.32056338028169	ISG15/IRF7/PIN1/IFIH1/MAPK14/RELA/ADAR/SIKE1/ZNFX1/TRAF6/MAPK12/MAPK8/MAP3K1/CHUK/TBKBP1/OTUD5/IKBKG/NFKBIA	1.31945552799869
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1775	110/9376	1.24853265044814	ANGPT2/EDN1/PIK3R3/CDKN1A/RBX1/SERPINE1/EGLN2/IL6/RELA/EIF4E/MAPK3/IFNGR1/MKNK2/EIF4EBP1/PLCG2/EPAS1/NOS3/PFKL/FLT1/HK1/AKT3/MTOR/ELOC/GAPDH/CAMK2G/RPS6KB2	1.26701890975748
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	40/1775	178/9376	1.18702326317455	LEF1/SOX17/NFATC1/NFATC2/FOSL1/RBX1/FZD6/RYK/CACYBP/SMAD3/RAC1/CSNK2B/SIAH1/CSNK1E/RUVBL1/AXIN2/SMAD4/MYC/CCND3/NLK/MAPK8/CUL1/LRP6/ZNRF3/FZD4/CCAR2/WNT2B/LGR4/WNT6/ROCK2/LRP5/VANGL1/CCDC88C/CTBP2/AXIN1/NKD1/CAMK2G/CELSR1/BAMBI/FRZB	1.2173301527628
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1775	59/9376	1.34294581045596	CDA/ENTPD1/NT5C3A/UPP1/CANT1/NT5C2/NUDT2/NME3/ENTPD4/DCTD/NME1/UCK2/RRM1/CMPK2/UMPS	1.27691771016891
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	35/1775	154/9376	1.20051216389245	PTS/AK2/NQO1/AK3/MTHFD2L/AK1/MOCS2/RFK/GCH1/NME3/ALPL/NME1/PANK2/MTHFD2/TPK1/GCLM/DLD/PANK3/ALDH2/AK6/ALAS1/COX10/UROD/CMPK2/FPGS/NADSYN1/LIAS/MMAB/PNPO/DHFR/OXSM/SPR/UMPS/PSAT1/RDH13	1.2123778016806
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1775	73/9376	1.30247347096276	PIK3R3/CDKN1A/FGFR1/KRAS/BAX/MAPK3/PDGFB/NRAS/MET/AKT3/ARAF/POLK/HRAS/DDB2/PDGFD/GADD45B/PDGFA/BRAF	1.25367989205118
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1775	50/9376	1.37338591549296	ICAM1/CCL2/ACKR1/SELE/PECAM1/THBS1/IL6/MYD88/MET/CD40/KLRB1/TGFB2/TGFB3	1.27921834561839
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/1775	155/9376	1.1927669241254	TUBB6/HLA-C/ATP6V1F/ITGA2/ITGA5/ATP6V1A/HLA-F/HLA-A/RAC1/ATP6AP1/THBS1/HLA-DMA/ATP6V0B/HLA-E/TUBB2A/ATP6V0C/DYNC1LI2/SEC61G/ATP6V1E1/ATP6V1G1/HLA-DRB1/DYNC1LI1/TUBA1A/CANX/TUBA4A/HLA-DRB5/TUBA1B/RILP/CTSL/TAP2/ATP6V1B2/HGS/ATP6V0A2/HLA-B/ATP6V0E1	1.16938846700428
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	15/1775	60/9376	1.32056338028169	KDR/NFATC2/PIK3R3/KRAS/PXN/RAC1/MAPK14/MAPK3/NRAS/PLCG2/NOS3/MAPK12/SHC2/AKT3/HRAS	1.20371658651436
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/1775	70/9376	1.28283299798793	ICAM1/HLA-C/ABL2/HLA-F/HLA-A/RAC1/HLA-DMA/HLA-E/CYCS/SNTB2/EIF4G2/HLA-DRB1/DAG1/HLA-DRB5/CD40/HLA-B/SNTB1	1.14774926558393
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	30/1775	133/9376	1.19148575664513	CREB5/CALML4/GNAI2/MAOA/GNG5/GNG12/KCNJ6/PPP2R1A/GNG10/PPP2R1B/PPP1CA/GNG11/CREB1/COMT/PPP1CC/MAPK14/GNB4/PPP2R3C/MAPK12/MAPK8/GNAI3/PPP2R2A/PPP1CB/AKT3/PPP2R5B/ATF6B/CALM1/CAMK2G/CALM2/GNAS	1.07474459532742
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1775	16/9376	1.65070422535211	NAGA/A4GALT/HEXB/B3GALNT1/FUT1	1.25879539193612
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1775	154/9376	1.16621181635266	CREB5/ATP1A1/CALML4/RAPGEF4/ADCY4/GNAI2/PPP2R1A/RPS6KA5/PPP2R1B/PPP1CA/CREB1/PPP1CC/MAPK14/PPP2R3C/MAPK3/CREM/TPM3/ATP2B1/MAPK12/GNAI3/PPP2R2A/PPP1CB/AKT3/ATP1B3/RYR2/PPP2R5B/ATF6B/RAPGEF3/ADCY6/CALM1/ADRB1/CAMK2G/CALM2/GNAS	1.0049840000284
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1775	30/9376	1.40860093896714	IL6/RELA/ABCG2/ABCC1/CHUK/FPGS/IKBKG/DHFR	1.08316981762164
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1775	49/9376	1.29361310721472	CREB5/FOSB/GNAI2/MAOA/CREB1/RELA/CDK5/GNAI3/ATF6B/GRM2/GPSM1/GNAS	0.995753728659527
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	22/1775	97/9376	1.1980368810803	CALML4/PER1/ADCY4/GNAI2/GNG5/GNG12/KCNJ6/RPS6KA5/GNG10/PER3/GNG11/CREB1/PER2/GNB4/MAPK3/GNAI3/RYR2/ADCY6/CALM1/CAMK2G/CALM2/GNAS	0.947394389142044
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/1775	17/9376	1.55360397680199	SCP2/HSD17B4/HSD3B7/AMACR/CYP39A1	1.10397283973796
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1775	17/9376	1.55360397680199	PCDH11X/PCDH7/PCDH1/DAG1/PCDH20	1.10397283973796
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	19/1775	83/9376	1.20919056507721	POLR3GL/POLR2K/IRF7/GSDMD/POLR2F/PCBP1/POLR2E/IL6/IL33/RELA/ADAR/MLKL/CASP1/POLR3K/PYCARD/CHUK/IKBKG/NFKBIA/POLR3B	0.925023191759975
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1775	69/9376	1.22487038171055	CREB5/CALML4/FOSB/MAOA/PPP1CA/CREB1/PPP1CC/HDAC1/HDAC2/PPP1CB/ATF6B/CALM1/ARC/CAMK2G/CALM2/GNAS	0.905944089904166
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1775	79/9376	1.20355143519344	VAMP2/STX3/ATP6V1F/CPLX1/ATP6V1A/DNM3/ATP6V0B/CLTB/UNC13B/ATP6V0C/ATP6V1E1/ATP6V1G1/AP2S1/SLC1A1/SLC1A2/ATP6V1B2/ATP6V0A2/ATP6V0E1	0.877941846016348
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/1775	168/9376	1.13191146881288	PRL/LEPR/IL3RA/IFNAR2/PIK3R3/CDKN1A/IL13RA1/IL10RB/OSMR/SOCS3/IL6/IFNAR1/STAT5A/PDGFB/IFNGR1/IL4R/BCL2L1/SOS2/MYC/CCND3/IRF9/PIAS3/PTPN2/SOCS4/TYK2/LIFR/SOS1/AKT3/MTOR/HRAS/GHR/IL27RA/PDGFA/JAK1/CSF2RB/IL11RA	0.833688848450345
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1775	36/9376	1.32056338028169	POLE4/RNASEH2C/MCM3/SSBP1/RPA3/RFC2/RFC3/PCNA/RPA1	0.931196150361445
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	22/1775	99/9376	1.17383411580595	ITGA6/EDN1/ITGA2/LMNA/ITGA5/PRKAA1/ITGA1/IL6/ITGA3/TPM3/SNTB2/EMD/DAG1/PRKAG1/RYR2/ITGA8/ITGB4/ACE/TGFB2/TGFB3/PRKAB2/SNTB1	0.840230191146231
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/1775	46/9376	1.26314758113901	ADRM1/PSMD7/PSMF1/PSMB2/PSMC6/PSMB6/POMP/PSMD6/PSMA2/PSME4/PSMA7	0.864543653252909
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	12/1775	51/9376	1.24288318144159	PLPP2/PAFAH1B2/PAFAH1B3/PLPP3/AGPS/PLD1/ENPP2/LPCAT1/LPCAT2/LPCAT4/CHPT1/CEPT1	0.840441639631632
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1775	32/9376	1.32056338028169	GABARAPL2/ATG2B/ATG101/MTOR/GABARAP/PIK3R4/ATG9A/ATG4D	0.877752214660238
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1775	32/9376	1.32056338028169	PMAIP1/TNFRSF1A/BAX/CYCS/BCL2L1/MAPK8/BIRC3/BBC3	0.877752214660238
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1775	110/9376	1.15249167733675	CDC25B/PIK3R3/ADCY4/GNAI2/CDC26/KRAS/RPS6KA2/ANAPC16/STK10/MAPK14/RPS6KA3/MAPK3/MAPK12/MAPK8/SPDYE2/GNAI3/CPEB3/AKT3/ARAF/CDK2/KIF22/ADCY6/SPDYA/BRAF	0.777402238369519
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	34/1775	160/9376	1.12247887323944	ICAM1/ICAM2/CDH5/CLDN5/ITGA6/ESAM/HLA-C/CD34/SELE/PECAM1/F11R/JAM2/CD58/HLA-F/HLA-A/HLA-DMA/HLA-E/CDH2/HLA-DRB1/PVR/CLDN15/NECTIN2/JAM3/CD99/HLA-DRB5/CD40/ITGA8/NECTIN3/CADM3/HLA-B/ALCAM/CLDN10/CLDN3/CLDN23	0.755091169300961
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/1775	155/9376	1.12460881417537	CREB5/LEF1/ORAI1/ADCY4/GNAI2/CDKN1A/NR4A1/LDLR/FZD6/AHR/NCEH1/CREB1/MAPK3/AXIN2/SP1/PDE8A/KMT2A/CDKN2C/ARMC5/GNAI3/FZD4/KMT2D/WNT2B/WNT6/ATF6B/CDK2/ADCY6/AXIN1/BRAF/CAMK2G/POMC/WDR5/GNAS	0.75591863513355
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1775	23/9376	1.37797917942437	SSBP1/RPA3/RFC2/RFC3/PCNA/RPA1	0.877012491797057
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1775	23/9376	1.37797917942437	REN/PRCP/LNPEP/MME/ACE/THOP1	0.877012491797057
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/1775	71/9376	1.19036699067645	PIK3R3/FGFR1/KRAS/MAPK3/NRAS/MYC/PKM/PFKL/MET/HK1/AKT3/MTOR/TIGAR/HRAS/SIRT6/SIRT3	0.778058194185116
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1775	101/9376	1.150589875889	LEF1/EDN1/CALML4/ADCY4/GNAI2/KRAS/FZD6/CREB1/MAPK3/NRAS/GNAI3/KITLG/FZD4/WNT2B/HRAS/WNT6/ADCY6/CALM1/CAMK2G/CALM2/POMC/GNAS	0.735273567546805
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1775	28/9376	1.32056338028169	ELOVL1/HACD3/ACOT7/HSD17B12/TECR/HACD2/PPT2	0.82088632982538
Genetic Information Processing	Transcription	hsa03040	Spliceosome	50/1775	243/9376	1.08688344056106	RBM8A/HSPA1B/HSPA1A/LSM5/MAGOH/SNRPA1/LSM8/SNU13/LSM3/SF1/TXNL4A/LSM2/PCBP1/LSM6/CCDC12/SNRPB/RBM22/ISY1/SF3B6/SNRPD3/SNRPF/PRPF38B/RBM17/PRPF38A/SYF2/RP9/SRSF8/SRSF1/SF3A1/SRSF2/SRSF10/TCERG1/SNRPE/PUF60/SRSF9/PRPF18/PRPF19/SF3B4/ALYREF/U2AF2/SRSF5/U2AF1/U2SURP/TRA2B/CRNKL1/RBMXL1/YJU2/HNRNPM/SRSF4/BUD13	0.66310586497537
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1775	122/9376	1.12572616024013	LEPR/CREB5/PIK3R3/PPP2R1A/ADIPOR1/PPP2R1B/CREB1/PRKAA1/ELAVL1/RAB11B/PPP2R3C/G6PC3/TBC1D1/ADIPOR2/EIF4EBP1/PFKL/RHEB/PPP2R2A/PRKAG1/AKT3/MTOR/PPP2R5B/STRADB/STRADA/PRKAB2/RPS6KB2	0.675445434459951
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	26/1775	122/9376	1.12572616024013	ATP1A1/PIK3R3/NOTCH4/KRAS/NOTCH1/TBC1D4/MAPK3/SIN3A/HDAC1/NRAS/MYC/PLCG2/MED30/HDAC2/PFKL/RHEB/MED17/AKT3/MTOR/HRAS/ATP1B3/MED12/KAT2A/RCAN2/RXRB/MED24	0.675445434459951
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1775	24/9376	1.32056338028169	EXT2/GLCE/HS3ST1/EXTL3/NDST1/EXT1	0.759830515802572
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1775	78/9376	1.15126038280968	MARCKSL1/HLA-DMA/MAPK14/RELA/MAPK3/IFNGR1/MYD88/TRAF6/MAPK12/HLA-DRB1/IRAK1/ELK1/HLA-DRB5/NFKBIA/TGFB2/TGFB3/JAK1	0.648227089384356
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1775	98/9376	1.13191146881288	SYNJ2/CALML4/PIK3R3/ITPKC/INPP1/CDIPT/DGKZ/DGKD/MTMR6/INPP5A/PIK3C2A/DGKH/IPPK/PLCG2/PIK3C2B/INPP5F/INPP5D/ITPKB/CALM1/CDS1/CALM2	0.634333810925353
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	30/1775	144/9376	1.10046948356808	LY96/LEF1/NOX4/CXCL2/TICAM1/MAP2K3/TNFRSF1A/CXCL3/ADIPOR1/PRKAA1/MAPK14/IL6/RELA/MAP2K4/MYD88/ADIPOR2/TRAF6/MAPK12/MAPK8/ALDH2/CHUK/PRKAG1/AKT3/IRAK1/TRA2B/IKBKG/MAP3K14/TIRAP/NFKBIA/PRKAB2	0.587106608279492
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/1775	39/9376	1.21898158179848	HLA-C/HLA-F/HLA-A/HLA-DMA/HLA-E/HLA-DRB1/HLA-DRB5/CD40/HLA-B	0.66219464328969
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1775	15/9376	1.40860093896714	AK2/AK1/ALPL/TPK1	0.765302827430482
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1775	44/9376	1.20051216389245	HLA-C/ICA1/HLA-F/HLA-A/HLA-DMA/HLA-E/PTPRN2/HLA-DRB1/HLA-DRB5/HLA-B	0.644212500359467
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/1775	59/9376	1.16388636906183	MGST2/GGT5/MGST3/TXNDC12/SRM/GGCT/GPX7/GCLM/ODC1/PGD/RRM1/LANCL1/GSTM4	0.610211294991757
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	44/1775	217/9376	1.07105601350036	MGST2/CREB5/KLF4/JAG1/PIK3R3/MGST3/ADCY4/GNAI2/KPNA4/KRAS/KPNA1/AHR/RPS6KA2/CREB1/RPS6KA3/RELA/MAPK3/STAT5A/KPNA3/NRAS/SOS2/MYC/CCND3/EIF4EBP1/GNAI3/ESR2/EPHX1/SOS1/PAQR8/AKT3/MTOR/EPHX4/HRAS/CHRNA7/ATF6B/DLL1/ADCY6/RXRB/ADRB1/HSP90B1/DLL4/GSTM4/RPS6KB2/GNAS	0.511747967417028
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/1775	166/9376	1.08190734770066	CREB5/NFATC1/NFATC2/ATP1A1/CALML4/ADCY4/GNAI2/GNA13/SLC25A5/MYLK/PPP1CA/CREB1/PPP1CC/MEF2D/MAPK3/ATP2B1/NOS3/GNAI3/PRKCE/PPP1CB/MEF2A/KCNMA1/AKT3/MEF2C/ATP1B3/ROCK2/ATF6B/KCNMB3/PDE3A/ADCY6/CALM1/ADRB1/CALM2/KCNMB4	0.514513225248497
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1775	30/9376	1.23252582159624	PIGK/PIGF/PIGC/PIGS/PIGH/PGAP2/B3GALT4	0.616408157082047
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1775	75/9376	1.12688075117371	MGST2/PIK3R3/MGST3/CDKN1A/PMAIP1/BAX/MAPK3/CYCS/SLC31A1/BCL2L1/AKT3/BIRC3/ATP7A/GSTM4/ATP7B/BBC3	0.533102846295619
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1775	126/9376	1.08998882181981	ORAI1/PIK3R3/ADCY4/GNAI2/ITGA2/GNA13/VWF/MYLK/PPP1CA/PPP1CC/RASGRP2/SNAP23/MAPK14/MAPK3/MYL12A/PRKCI/PLCG2/NOS3/MAPK12/GNAI3/PPP1CB/AKT3/ROCK2/ARHGEF12/ADCY6/GNAS	0.491419541814169
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1775	86/9376	1.10558794628235	LEF1/ITGA6/ITGA2/LMNA/ITGA5/DSP/ITGA1/ITGA3/JUP/CDH2/SNTB2/EMD/CTNNA1/DAG1/RYR2/ITGA8/ITGB4/SNTB1	0.475340875845276
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1775	66/9376	1.12047801963295	NFATC1/SMAD3/SMAD2/HLA-DMA/IL6/RELA/IFNGR1/IL4R/HLA-DRB1/HLA-DRB5/IL18R1/TGFB2/TGFB3/TLR5	0.474629139708554
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/1775	138/9376	1.07176158399673	YWHAH/CALML4/ADCY4/CDC26/PPP2R1A/RBX1/YWHAG/RPS6KA2/ANAPC16/PPP2R1B/PPP1CA/PPP1CC/MAPK14/RPS6KA3/MAPK3/MAPK12/CUL1/SPDYE2/PPP1CB/CPEB3/PPP2R5B/CDK2/ADCY6/CALM1/SPDYA/CAMK2G/CALM2/FBXO5	0.410385522311019
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1775	154/9376	1.06331077373331	NFATC1/NFATC2/CALML4/ADCY4/GNAI2/CDKN1A/KRAS/KCNJ6/MYLK/PPP1CA/PRKAA1/PPP1CC/MAPK3/CAMK1D/NRAS/NOS3/GNAI3/PPP1CB/MAPK7/PRKAG1/ELK1/MEF2C/HRAS/RYR2/ROCK2/ADCY6/CALM1/CAMK2G/CALM2/PRKAB2/GNAS	0.382802595071784
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/1775	144/9376	1.06378716744914	PIK3R3/ADRM1/SLC25A5/PSMD7/ATXN3/ATG2B/CYCS/PSMB2/ATXN2L/PSMC6/SP1/OPA1/AFG3L2/TBPL1/PSMB6/ATG101/MAPK8/PSMD6/CIC/PSMA2/AKT3/MTOR/ATXN1L/PIK3R4/KAT5/NFYA/TBP/PUM1/PSMA7	0.372748681518257
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1775	57/9376	1.11205337286879	ELOVL1/HACD3/HSD17B12/ACSL5/SCP2/HSD17B4/TECR/HACD2/ACSL3/PPT2/OXSM/ACADSB	0.410040879313664
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1775	52/9376	1.11739978331528	APOA1/NPC1/LDLR/NCEH1/STARD3NL/LIPA/VAPA/STARD3/APOC3/CETP/LDLRAP1	0.410220429847757
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/1775	238/9376	1.04313409870991	ISG15/CCL2/IFNAR2/PIK3R3/HBEGF/VWF/TNFRSF1A/IFIH1/OAS2/MAPK14/IL6/MX1/RPL36AL/IFNAR1/RELA/MAPK3/ADAR/RPL22L1/MYD88/TRAF6/IRF9/PLCG2/MAPK12/MAPK8/RPL39/CASP1/RPS27A/TYK2/OAS3/CHUK/IRAK1/IKBKG/ACE/RPS28/RPL28/RPL26/NFKBIA/UBA52/RPS15/MMP1/RPL36A/OAS1/RPS15A/RPS23/JAK1/RPS16/CFB	0.325711490656999
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1775	37/9376	1.14210886943281	PGM2/GPI/GNPNAT1/HK1/GALE/FCSK/NANP/UAP1L1	0.418524907736421
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1775	78/9376	1.08353918382087	SYNJ2/ITPKC/INPP1/CDIPT/MTMR6/INPP5A/PIK3C2A/IPPK/PLCG2/PIK3C2B/INPP5F/INPP5D/INPP5K/ISYNA1/ITPKB/MINPP1	0.35800756927798
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1775	99/9376	1.06712192345995	CALML4/PIK3R3/ADCY4/MAP2K3/PPP1CA/PPP1CC/MAPK14/HRH1/PLCG2/MAPK12/MAPK8/TRPV2/PRKCE/PPP1CB/IL1RAP/ADCY6/CALM1/CAMK2G/CALM2/GNAS	0.324434972487308
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1775	63/9376	1.08998882181981	LEF1/CDKN1A/FZD6/BAX/AXIN2/FZD4/WNT2B/POLK/WNT6/DDB2/GADD45B/BMP2/AXIN1	0.346308769892596
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1775	89/9376	1.0683209368571	ITGA6/LAMA5/ITGA2/VWF/ITGA5/THBS1/ITGA1/HSPG2/ITGA3/LAMB2/DAG1/AGRN/ITGA8/ITGB4/VTN/FRAS1/FN1/LAMC2	0.312939615197016
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1775	100/9376	1.05645070422535	ACKR3/CCL14/CCL2/CXCL2/IL10RB/TNFRSF1A/CXCL3/TNFSF10/TNFRSF1B/IL6/CCL23/TNFRSF10D/TNFRSF10A/TNFRSF10B/XCL2/CSF1/IL18R1/CCL21/CCL8/CX3CL1	0.274244827272925
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1775	38/9376	1.11205337286879	PGM2/HEXB/GPI/GNPNAT1/HK1/GALE/FCSK/UAP1L1	0.3344561973758
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1775	38/9376	1.11205337286879	PNP/NT5C2/NMRK1/NADSYN1/NNMT/SIRT6/SIRT5/SIRT3	0.3344561973758
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1775	33/9376	1.12047801963295	CS/DLD/BCKDHA/GOT2/DLAT/ACY1/NAGS	0.335020256122632
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1775	28/9376	1.13191146881288	B3GNT5/B3GNT2/B4GALT3/A4GALT/B3GALNT1/FUT1	0.337793797284408
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1775	23/9376	1.14831598285364	ARG2/NOS3/GOT2/ACY1/NAGS	0.344132631574829
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1775	23/9376	1.14831598285364	IDI1/FNTA/FDPS/NUS1/RCE1	0.344132631574829
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1775	18/9376	1.17383411580595	AGA/HEXB/MAN2C1/GBA2	0.356721426187256
Human Diseases	Substance dependence	hsa05032	Morphine addiction	18/1775	91/9376	1.04484135582727	ADCY4/GNAI2/PDE4D/GNG5/GNG12/KCNJ6/GNG10/GNG11/GNB4/PDE8A/GNAI3/GRK5/PDE1A/PDE1C/PDE3A/ADCY6/PDE7B/GNAS	0.207710249900028
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1775	65/9376	1.05645070422535	CREB5/ORAI1/ADCY4/NR4A1/LDLR/NCEH1/CREB1/SP1/PDE8A/ATF6B/ADCY6/POMC/GNAS	0.220687294127211
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1775	60/9376	1.05645070422535	GNAI2/KRAS/PPP2R1A/GNA13/PPP2R1B/MAPK3/NRAS/GNAI3/ARAF/HRAS/BRAF/GNAS	0.211972586939788
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1775	50/9376	1.05645070422535	MAOA/SRM/SMOX/ARG2/NOS3/ODC1/ALDH2/PYCR2/GOT2/CKMT2	0.193399840411255
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/1775	45/9376	1.05645070422535	HLA-C/HLA-F/HLA-A/HLA-DMA/IL6/HLA-E/HLA-DRB1/HLA-DRB5/HLA-B	0.183426034424998
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	57/1775	298/9376	1.01036392853767	PRL/TNFRSF6B/LEPR/ACKR3/CCL14/CCL2/IL3RA/IFNAR2/ACVRL1/TNFRSF21/CXCL2/IL1RL1/TGFBR1/IL13RA1/IL10RB/TNFRSF1A/CXCL3/BMP6/IL32/TNFSF10/TNFRSF1B/RELL1/TNFSF9/OSMR/IL6/IFNAR1/IL33/CCL23/IFNGR1/IL4R/TNFRSF10D/TNFRSF10A/TNFRSF10B/ACVR1/TNFSF12/XCL2/LIFR/CSF1/RELT/IL1RAP/CD40/IL18R1/TNFRSF4/GHR/ACVR2B/TGFB2/IL27RA/CCL21/BMP2/TGFB3/GDF15/CCL8/CX3CL1/CSF2RB/IL11RA/ACVR1B/BMPR2	0.0878591309562483
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1775	19/9376	1.11205337286879	GNS/HYAL2/HEXB/HYAL1	0.236256012619667
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1775	19/9376	1.11205337286879	DLD/LIAS/BCKDHA/DLAT	0.236256012619667
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1775	14/9376	1.13191146881288	B3GNT2/B4GALT3/CHST1	0.238677624209225
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	32/1775	168/9376	1.00614352783367	IFNAR2/CHMP1B/TICAM1/TNFRSF1A/SLC25A5/CHMP5/CFLAR/TNFAIP3/TNFSF10/BAX/IFNAR1/IL33/RBCK1/STAT5A/IFNGR1/MLKL/TNFRSF10A/TNFRSF10B/IRF9/MAPK8/CHMP1A/CASP1/TYK2/PYCARD/PPIA/SPATA2/CHMP4C/CHMP7/BIRC3/SPATA2L/CAMK2G/JAK1	0.038827485518635
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	20/1775	105/9376	1.00614352783367	ITGA6/ADCY4/ITGA2/LMNA/ITGA5/ITGA1/ITGA3/TPM3/SNTB2/EMD/DAG1/RYR2/ITGA8/ITGB4/ADCY6/TGFB2/TGFB3/ADRB1/SNTB1/GNAS	0.0305913497862103
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1775	36/9376	1.0271048513302	PGM2/G6PC3/GYG1/GPI/HK1/PGM2L1/GBE1	0.0787361712764121
Human Diseases	Substance dependence	hsa05034	Alcoholism	36/1775	191/9376	0.995607993510803	CREB5/CALML4/FOSB/GNAI2/MAOA/GNG5/GNG12/KRAS/SHC1/GNG10/PPP1CA/GNG11/CREB1/PPP1CC/GNB4/MAPK3/HDAC7/HDAC1/NRAS/SOS2/HDAC2/SHC2/GNAI3/PPP1CB/HDAC5/SOS1/ARAF/PKIA/HRAS/ATF6B/CALM1/SLC29A1/HDAC9/BRAF/CALM2/GNAS	-0.0296339488580786
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1775	47/9376	1.01149535510938	PIK3R3/SOCS3/MAPK3/PKM/MAPK8/PRKCE/HK1/SOCS4/MTOR	0.0381771254372841
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1775	31/9376	1.02237164925034	PGM2/RBKS/PFKL/PGD/GPI/GLYCTK	0.0602890785744366
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	22/1775	117/9376	0.993244251835801	BCL7B/TFPT/BAZ2A/RUVBL1/SMARCD1/GATAD2A/HDAC1/CDK2AP1/CDK2AP2/HDAC2/YY1/MTA1/INO80C/BCL7A/VPS72/YEATS4/MORF4L1/KAT5/MCRS1/BICRA/MRGBP/SS18L1	-0.0355331567181666
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1775	42/9376	1.00614352783367	SLC3A2/SLC39A8/PCBP2/PCBP1/ACSL5/SLC7A11/GCLM/ACSL3	0.0192822641389681
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1775	53/9376	0.996651607759766	ATP1A1/DNM3/CLTB/ATP2B1/AP2S1/ATP1B3/RAB11A/ADCY6/KL/GNAS	-0.0118126101195326
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1775	15/9376	1.05645070422535	ST6GALNAC3/HEXB/B3GALT4	0.105731239050282
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	42/1775	226/9376	0.981657734014708	CREB5/ORAI1/NFATC1/EDN1/ATP1A1/CALML4/PIK3R3/RAPGEF4/ADCY4/GNAI2/PDE4D/AFDN/PPP1CA/CREB1/RAC1/PPP1CC/RELA/VAV2/MAPK3/ARAP3/FXYD1/ATP2B1/MAPK8/GNAI3/PPP1CB/PLD1/AKT3/ATP1B3/RYR2/ROCK2/RAPGEF3/PDE3A/ADCY6/CALM1/NFKBIA/BRAF/ADRB1/CAMK2G/CALM2/POMC/GNAS/VIPR2	-0.13487955055414
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1775	32/9376	0.990422535211268	PGM2/G6PC3/AKR1B1/PFKL/HK1/GALE	-0.0262245828633112
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1775	21/9376	1.00614352783367	AASDHPPT/PANK2/PANK3/ALDH2	0.0136193077100083
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1775	38/9376	0.973046701260193	SGK1/ATP1A1/PIK3R3/KRAS/MAPK3/NEDD4L/ATP1B3	-0.080450035304208
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1775	83/9376	0.954624130324113	FAR1/MPV17/ACSL5/SCP2/HACL1/HSD17B4/AGPS/ACSL3/PRDX1/PEX13/ECH1/PEX19/PEX16/NUDT19/AMACR	-0.200648302570344
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1775	100/9376	0.950805633802817	IL3RA/ITGA6/CD34/ITGA2/CD9/ITGA5/CD59/ITGA1/HLA-DMA/IL6/IL4R/ITGA3/MME/HLA-DRB1/KITLG/CSF1/HLA-DRB5/IL11RA	-0.238992597978761
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/1775	134/9376	0.946075257515241	RAMP2/EDN1/CALML4/ADCY4/RAMP3/GNA13/MYLK/PPP1CA/PPP1CC/MAPK3/PRKCE/PPP1CB/KCNMA1/ADM/ARAF/ROCK2/ARHGEF12/KCNMB3/ADCY6/CALM1/BRAF/CALM2/KCNMB4/GNAS	-0.303813415806561
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	42/1775	233/9376	0.952165870761047	ITGA6/ATP1A1/BGN/PDLIM5/ITGA2/NID2/LMNA/ITGA5/THBS1/DSP/ITGA1/CSRP2/PDLIM7/HSPG2/FBN2/ITGA3/SUN1/DIAPH1/CAPZA2/TPM3/JUP/SPTAN1/LBR/ELN/SNTB2/NEBL/PDLIM1/FMNL3/SUN2/EMD/SPTBN1/DAG1/INF2/PDLIM3/ATP1B3/AGRN/ITGA8/ITGB4/TMOD2/FN1/SNTB1/MYOM3	-0.357290051583537
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1775	35/9376	0.905529175050302	AKR1B1/PFKL/HK1/HSD17B14/TIGAR/FCSK	-0.270573023418872
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1775	86/9376	0.921323288568621	CREB5/VAMP2/ATP1A1/RAPGEF4/ADCY4/CREB1/KCNMA1/ATP1B3/RYR2/ATF6B/KCNMB3/ADCY6/CAMK2G/KCNMB4/GNAS	-0.354190589335014
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1775	18/9376	0.88037558685446	ACSL5/ACSL3/OXSM	-0.245478806425584
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1775	12/9376	0.88037558685446	NPC1/CD46	-0.200368382069008
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1775	30/9376	0.88037558685446	MDH2/CS/SDHD/DLD/DLAT	-0.317115163997144
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1775	115/9376	0.918652786282915	CREB5/PIK3R3/ADCY4/GNAI2/GNG5/GNG12/KRAS/KCNJ6/GNG10/GNG11/CREB1/GNB4/MAPK3/NRAS/GNAI3/AKT3/HRAS/CHRNA7/ADCY6/CAMK2G	-0.424142811547208
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1775	115/9376	0.918652786282915	GNAI2/MAOA/GNG5/GNG12/DUSP1/KRAS/KCNJ6/GNG10/GNG11/GNB4/MAPK3/NRAS/APP/GNAI3/ARAF/HRAS/RAPGEF3/KCND2/BRAF/GNAS	-0.424142811547208
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1775	59/9376	0.895297206970637	PIK3R3/ADCY4/GNAI2/PNPLA2/GNAI3/AKT3/ADCY6/ADRB1/GNAS/PLIN1	-0.389848327773968
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1775	76/9376	0.903543365455893	ATP1A1/CALML4/ADCY4/GNAI2/MYLK/GNAI3/ATP1B3/ADCY6/CALM1/CAMK2G/CALM2/KCNJ15/GNAS	-0.407987518915581
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1775	82/9376	0.901848162143593	MGST2/MGST3/CDA/UPP1/NME3/HPRT1/NME1/UCK2/TPMT/IMPDH1/RRM1/CES2/UMPS/GSTM4	-0.431373516506439
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1775	54/9376	0.88037558685446	CENPX/RPA3/POLK/RAD51C/ERCC4/FANCC/USP1/RPA1/TELO2	-0.426001964126152
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1775	54/9376	0.88037558685446	HLA-C/HLA-F/HLA-A/HLA-DMA/HLA-E/HLA-DRB1/HLA-DRB5/CD40/HLA-B	-0.426001964126152
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1775	31/9376	0.851976374375284	MDH2/CS/DLD/PGP/GLYCTK	-0.398907022736624
NA	NA	hsa04981	Folate transport and metabolism	5/1775	31/9376	0.851976374375284	FOLH1/ABCG2/ABCC1/FPGS/DHFR	-0.398907022736624
Genetic Information Processing	Translation	hsa03010	Ribosome	39/1775	222/9376	0.927963456414161	MRPL42/MRPL33/MRPL47/MRPL12/MRPL32/MRPS33/MRPL41/MRPS18C/RPL36AL/MRPL52/MRPS21/MRPL17/RPL22L1/MRPS17/MRPS28/MRPL9/MRPL22/MRPL50/MRPL15/RPL39/MRPL13/RPS27A/MRPL46/MRPL48/MRPS23/MRPL2/MRPL16/MRPS18A/RPS28/MRPL35/RPL28/RPL26/UBA52/RPS15/RPL36A/MRPL10/RPS15A/RPS23/RPS16	-0.524896105372808
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1775	37/9376	0.85658165207461	APOA1/ICAM1/SELE/IL6/MYD88/THOP1	-0.422381453548629
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1775	43/9376	0.85990173599738	APOA1/PLPP2/PLPP3/AGPAT1/DGAT1/AGPAT2/GOT2	-0.444944455507164
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1775	67/9376	0.867235652722304	PGM2/G6PC3/PKM/PFKL/DLD/GPI/HK1/ALDH2/GAPDH/MINPP1/DLAT	-0.527007506847239
Human Diseases	Immune disease	hsa05310	Asthma	5/1775	32/9376	0.825352112676056	FCER1A/HLA-DMA/HLA-DRB1/HLA-DRB5/CD40	-0.478212981625086
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1775	38/9376	0.834040029651594	ORAI1/RFXANK/CD40/IKBKG/TAP2/RFXAP	-0.495356267984216
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1775	56/9376	0.848933601609658	CSNK1G3/CSNK1E/MOSMO/SMURF2/SMURF1/CUL1/SPOPL/HHAT/CDON	-0.547902627558411
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1775	20/9376	0.792338028169014	CYB5R3/NANP/UAP1L1	-0.449237824439054
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1775	103/9376	0.871828251059757	PIK3R3/CXCL2/LAMA5/CXCL3/IL6/RELA/ACTN4/SERPINB9/ARG2/LAMB2/SERPINB6/PRDX1/TGFB2/TGFB3/FN1/LAMC2/GNAS	-0.632048265016014
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1775	45/9376	0.821683881064163	ABCB1/ABCG1/ABCG2/ABCC1/TAP2/ABCC10/ABCB4	-0.579404969686238
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1775	63/9376	0.838452939861391	KMT5B/KMT2A/DLD/ALDH2/KMT2E/KMT2D/SMYD3/SETMAR/MECOM/TMLHE	-0.621690144898116
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1775	116/9376	0.865196697425935	SHANK3/ADCY4/GNAI2/GNG5/GNG12/GNG10/GNG11/GNB4/MAPK3/SLC38A2/GNAI3/PLD1/SLC1A1/ADCY6/SLC1A2/GRIK4/GRM2/GRM5/GNAS	-0.705949254767294
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/1775	93/9376	0.851976374375284	VAMP2/ATP1A1/CALML4/ADCY4/SLC12A2/ATP2B1/KCNMA1/ATP1B3/ADCY6/CALM1/CAMP/ADRB1/CALM2/CST3/GNAS	-0.693230699561584
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1775	46/9376	0.803821187997551	HMOX2/HCCS/HEPH/ALAS1/COX10/UROD/MMAB	-0.644524817918882
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/1775	88/9376	0.840358514724712	THBD/PROS1/A2M/CFH/VWF/CD59/CLU/SERPINE1/CFI/SERPING1/SERPINA5/CD46/VTN/CFB	-0.727068690313463
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1775	47/9376	0.786718609529517	MDH2/HAGH/PKM/ACYP1/DLD/ALDH2/DLAT	-0.708326999901561
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1775	107/9376	0.839236540739766	CREB5/CALML4/PRMT1/CREB1/PRKAA1/PPP4C/G6PC3/PKM/PFKL/PRKAG1/AKT3/CALM1/CAMK2G/CALM2/PRKAB2/PHKA2/GNAS	-0.808187708385256
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1775	54/9376	0.782556077203964	CISD1/MDH2/SRM/AHCYL1/GCLM/ENOPH1/GOT2/PSAT1	-0.774353125441939
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1775	16/9376	0.660281690140845	MAOA/GOT2	-0.657189282543271
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1775	23/9376	0.688989589712186	B4GALT3/POMGNT1/B4GAT1	-0.721627088869628
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1775	23/9376	0.688989589712186	AQP1/ATP1A1/ATP1B3	-0.721627088869628
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1775	17/9376	0.621441590720795	GGT5/ADO	-0.754904624263797
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1775	75/9376	0.774730516431925	CREB5/ATP1A1/ADCY4/CREB1/GPX7/CANX/ATP1B3/ATF6B/ADCY6/HSP90B1/GNAS	-0.946493473302901
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1775	44/9376	0.720307298335467	POLE4/RFC2/RFC3/PCNA/NEIL1/MUTYH	-0.898606504332835
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1775	89/9376	0.771565121063459	ADCY4/GNAI2/GNG5/GABARAPL2/GNG12/KCNJ6/GNG10/GNG11/GNB4/SLC38A2/GNAI3/GABARAP/ADCY6	-1.04633113069718
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1775	39/9376	0.677211989888046	MTHFD2L/MTHFD2/AHCYL1/DLD/DHFR	-0.976102599400232
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1775	65/9376	0.73138894907909	PIK3R3/KRAS/KCNJ6/MAPK3/NRAS/ESR2/AKT3/HRAS/GPER1	-1.05010286078556
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1775	41/9376	0.644177258673995	MAOA/DLD/ALAS1/GLYCTK/PSAT1	-1.10336173678531
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1775	41/9376	0.644177258673995	SSBP1/RPA3/RAD51C/TOPBP1/RPA1	-1.10336173678531
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1775	48/9376	0.660281690140845	HIBCH/DLD/ALDH2/MCCC2/BCKDHA/ACADSB	-1.14023601772204
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1775	48/9376	0.660281690140845	ATP1A1/PIK3R3/G6PC3/HK1/AKT3/ATP1B3	-1.14023601772204
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1775	12/9376	0.44018779342723	NQO1	-0.937673700074901
NA	NA	hsa04081	Hormone signaling	34/1775	219/9376	0.820075889124703	PRL/RAMP2/LEPR/SMAD9/PIK3R3/RAPGEF4/ADCY4/GNAI2/GNG5/GNG12/RAMP3/GNA13/GNG10/ADIPOR1/GNG11/GNB4/STAT5A/SMAD1/SMAD4/ADIPOR2/ACVR1/NPR3/HEPH/GNAI3/ESR2/RAPGEF3/GPER1/GHR/ADCY6/AVPR2/ADRB1/POMC/GNAS/VIPR2	-1.30191990266591
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1775	254/9376	0.831850948208939	KDR/ORAI1/NFATC1/NFATC2/CALML4/ADCY4/FGFR1/SLC25A5/ASPH/MYLK/ITPKC/HRH1/PDGFB/CAMK1D/ORAI2/ATP2B1/PLCG2/NOS3/STIM2/FLT1/MET/FLT4/TFEB/PDE1A/RYR2/CHRNA7/PDE1C/ITPKB/PDGFD/CYSLTR1/CALM1/PDGFA/MCOLN3/ADRB1/CAMK2G/CALM2/PTK2B/PHKA2/GRM5/GNAS	-1.31285178086348
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1775	75/9376	0.704300469483568	CS/ARG2/PKM/PFKL/PYCR2/GOT2/GAPDH/PSAT1/ACY1/NAGS	-1.24241273722261
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1775	21/9376	0.503071763916834	CHST12/CSGALNACT1	-1.10161762756543
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1775	43/9376	0.614215525712414	ACSL5/ECI1/ACSL3/ALDH2/ACADSB	-1.22523047717277
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/1775	50/9376	0.633870422535211	HLA-DMA/IL6/HLA-DRB1/HLA-DRB5/CD40/MAP3K14	-1.2543581665316
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1775	29/9376	0.546440019426906	CALML4/CALM1/CALM2	-1.18208050852354
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1775	90/9376	0.704300469483568	AQP1/ATP1A1/ADCY4/LDLR/NCEH1/ABCB1/ABCG2/EPHX1/ATP1B3/ADCY6/ABCB4/GNAS	-1.36209375160918
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1775	22/9376	0.480204865556978	MAOA/ALDH2	-1.17949014944998
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/1775	194/9376	0.78961521707565	TUBB6/MYO1D/KIFC3/KIF9/KLC1/MYO1B/ACTR1A/DYNLRB1/MYL12A/TUBB2A/DYNLL2/DYNC1LI2/CAPZA2/TPM3/ACTR10/DCTN6/MYO6/DYNC1LI1/TUBA1A/TUBG1/TUBA4A/TUBA1B/MYO15B/KIF22/MYO1E/DYNLL1/KIF4A/DNAL1/KIF26A	-1.43085621949318
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/1775	116/9376	0.728586692569208	HIBCH/MDH2/CS/SDHD/PKM/PFKL/PGD/DLD/GPI/HK1/PGP/GOT2/GAPDH/GLYCTK/DLAT/PSAT1	-1.42135999976277
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1775	52/9376	0.609490790899242	ADCY4/LDLR/BMP6/AKR1C3/ADCY6/GNAS	-1.36452428695391
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1775	31/9376	0.51118582462517	ALDH2/HSD17B14/KL	-1.31729922535875
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1775	31/9376	0.51118582462517	HIBCH/SMOX/ALDH2	-1.31729922535875
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1775	32/9376	0.495211267605634	HIBCH/DLD/BCKDHA	-1.38218977914863
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1775	102/9376	0.673228389947528	CPB1/ATP1A1/ADCY4/RAC1/SLC12A2/ATP2B1/KCNMA1/ATP1B3/RYR2/RAB11A/ADCY6/PRSS3/GNAS	-1.60346804222997
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1775	26/9376	0.406327193932828	NR5A2/HHEX	-1.46479711238781
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1775	17/9376	0.310720795360398	CA13	-1.37453044559772
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1775	36/9376	0.44018779342723	DCXR/AKR1B1/KL	-1.62618378689365
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1775	37/9376	0.428290826037305	MAOA/COMT/GOT2	-1.6837409954762
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1775	103/9376	0.615408177218652	CPB1/SLC3A2/ATP1A1/PRCP/COL14A1/SLC38A2/ELN/MME/SLC1A1/ATP1B3/PRSS3/COL17A1	-1.89652241104728
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1775	76/9376	0.556026686434396	APOA1/ACSL5/SCP2/ACSL3/APOC3/RXRB/MMP1/PLIN1	-1.87789644043129
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/1775	99/9376	0.586917057902973	ICAM1/CFH/KRT10/HLA-DMA/KRT18/CFI/KRT23/HLA-DRB1/HLA-DRB5/CAMP/CFB	-1.99664351147785
NA	NA	hsa04382	Cornified envelope formation	29/1775	217/9376	0.705923281625235	CLDN5/ITGA6/S100A10/LAMA5/ELOVL1/FURIN/PPP2R1A/KRT10/UGCG/PPP2R1B/DSP/KDSR/KRT18/PPP2R3C/SPTLC1/KRT23/JUP/S100A11/PPP2R2A/CLDN15/S100A1/GBA2/PPP2R5B/ITGB4/CLDN10/CLDN3/LAMC2/COL17A1/CLDN23	-2.11795111320451
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1775	42/9376	0.377303822937626	MAOA/DLD/ALDH2	-1.95441324423402
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1775	63/9376	0.419226469930695	GGT5/AKR1C3/LTC4S/PTGES2/PRXL2B	-2.2350216695493
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	44/1775	323/9376	0.719563947150395	HOXD10/CDC25B/PIK3R3/MMP9/EFNA1/CDKN1A/RASSF1/NOTCH4/FSCN1/KRAS/RPS6KA5/ITGA5/SHC1/NOTCH1/THBS1/ABCB1/CRK/SLC7A1/SOX4/MAPK3/PDGFB/SPRY2/CCNG1/HDAC1/NRAS/SOS2/MYC/PLCG2/HDAC2/ABCC1/PRKCE/MET/MAPK7/HDAC5/PAK4/SOS1/MTOR/HRAS/BMF/TGFB2/FOXP1/PDGFA/BCL2L2/BMPR2	-2.47849642822547
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1775	37/9376	0.285527217358203	FOLH1/GOT2	-2.10419417611873
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1775	66/9376	0.400170721297482	HSD17B12/COMT/AKR1C3/SRD5A3/HSD17B11	-2.36305722313448
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1775	195/9376	0.568858071505959	PIK3R3/VWF/SLC25A5/GSDMD/RAC1/MAPK14/RELA/MAPK3/HDAC7/HDAC1/PLCG2/MAPK12/HDAC2/CASP1/HDAC5/AKT3/MTOR/CLCN5/HDAC9/CAMP/CLCN4	-2.9399640684651
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1775	68/9376	0.310720795360398	DHRS4L2/DGAT1/RDH13/RETSAT	-2.75658187220226
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1775	70/9376	0.301843058350101	MGST2/MGST3/EPHX1/GSTM4	-2.83315285960797
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1775	183/9376	0.519565920110829	NXT1/NOP10/SNU13/CSNK2B/RRP7A/RPP30/EIF6/GTPBP4/REXO1/IMP3/NHP2/XRN2/RPP40/GNL2/AK6/NOB1/RIOK1/POP7	-3.17161287520988
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1775	73/9376	0.289438549102836	MGST2/MGST3/MAOA/GSTM4	-2.94510655834063
NA	NA	hsa04082	Neuroactive ligand signaling	20/1775	199/9376	0.530879750867011	ADCY4/GNAI2/GNG5/GNG12/GNG10/GNG11/GNB4/HRH1/GNAI3/SLC1A1/CHRNA7/OGFR/ADCY6/SLC1A2/GRIK4/ADRB1/GRM2/POMC/GRM5/GNAS	-3.23228615689975
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1775	41/9376	0.128835451734799	CHRNA7	-2.7013721085326
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1775	79/9376	0.267455874487431	MGST2/MGST3/EPHX1/GSTM4	-3.15955100601357
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1775	86/9376	0.245686210284966	ADCY4/PDE1A/PDE1C/ADCY6	-3.39580596166275
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1775	143/9376	0.258571850684527	SNRPB/HLA-DMA/SNRPD3/ACTN4/HLA-DRB1/HLA-DRB5/CD40	-4.31732877175254
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1775	370/9376	0.371185382565664	PRL/S1PR1/LEPR/EDN1/PGRMC1/NR3C1/RXFP1/LPAR6/HRH1/GAL/PGRMC2/ADM/CHRNA7/OGFR/GHR/CYSLTR1/PRSS3/GRIK4/AVPR2/ADRB1/GRM2/POMC/LTB4R/GRM5/TMEM97/VIPR2	-5.96357890872736
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1775	449/9376	0.0941158756548198	CALML4/ANO2/PDE1A/PDE1C/CALM1/CAMK2G/CALM2/OR52N1	-9.50588382777081