category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	35/646	138/9376	3.68106968187733	RPS6KA3/ACTB/FYB1/RPS6KA2/LCP2/ITGB1/ZAP70/WIPF3/ARPC2/VAV3/ARPC5L/ELMO1/RAC2/IRAK4/PKN2/ARPC4/ACTR2/GIT2/PIK3R1/ACTR3/TBK1/ROCK1/GSK3B/MAPK14/ARF6/MAP2K4/PTK2B/ITGA4/WIPF1/MAPK8/ARHGEF7/RHOG/WAS/PIK3CB/GNAQ	8.63084746273322
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/646	253/9376	2.58152938729059	ACTB/ITGB1/PFN1/SEPTIN7/CYTH1/MYL12A/CAST/ARPC2/MALT1/ARPC5L/ELMO1/BCL2/BTRC/ARPC4/RBX1/ACTR2/CUL1/PIK3R1/ACTR3/TBK1/DIAPH1/ITPR2/ROCK1/GSK3B/ATG16L1/HCLS1/SEPTIN11/MAPK14/ACTN4/ARF6/PIK3C3/BCL10/MAPK8/RPS6KA5/SEPTIN6/FBXW11/CYTH4/FNBP1/HKDC1/C3/CBX3/ITPR1/ATG5/PIK3CB/UBE2N	6.93686854636166
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/646	142/9376	3.06632363842498	BIRC6/COP1/HERC1/ITCH/UBA6/FBXW7/PIAS1/FBXW8/BTRC/TRIP12/UBE2K/RBX1/WWP1/CUL1/MAP3K1/CBL/PML/HERC3/UBE2O/UBR5/UBE4A/FBXW11/FANCL/CDC27/UBE2W/HERC4/UBE2J1/PIAS2/UBE2N/SMURF2	6.74904550595343
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/646	250/9376	2.43834055727554	LDLR/ITCH/CYTH1/EPS15/WIPF3/VPS37B/ARPC2/SMAP2/ARPC5L/PLD1/RAB11FIP1/ACAP2/STAM/CAPZA1/ARPC4/ACTR2/WWP1/GIT2/ACTR3/ASAP1/PDCD6IP/WASHC4/RAB10/SMAD2/CBL/SMAP1/CHMP5/ARF6/USP8/PML/WIPF1/ZFYVE16/CAPZB/ARFGAP3/CYTH4/RABEP1/ARAP2/ARFGEF1/VPS36/IL2RA/SMURF2/GBF1	6.27027046059403
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/646	232/9376	2.43984199850539	ACTB/ITGA1/SOS1/PIP4K2A/ITGB1/PFN1/SSH2/RRAS2/IQGAP2/MYL12A/ARPC2/VAV3/ARPC5L/ITGAM/ITGAD/ARHGEF6/RAC2/PPP1R12A/BRAF/TIAM1/ARPC4/ACTR2/PIK3R1/KRAS/ACTR3/NCKAP1L/DIAPH1/IQGAP1/ROCK1/ACTN4/CFL1/ITGA4/ARHGEF7/PPP1R12B/SOS2/ARHGAP35/PAK2/PIK3CB/ITGAL	6.04067536019248
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	24/646	120/9376	2.90278637770898	RPS6KA3/SOS1/RPS6KA2/BCL2/BRAF/IRAK4/PIK3R1/KRAS/RAP1A/ARHGDIB/CAMK2G/GSK3B/MAP3K1/ABL1/MAPK14/RAP1B/MAP2K5/MAPK8/RPS6KA5/SOS2/MAGED1/PIK3CB/SH2B3/CALM3	5.70642033958652
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	24/646	122/9376	2.85519971577932	PTPRC/PPP2R2B/SOS1/PPP3CA/LCP2/ITK/DLG1/ZAP70/VAV3/MALT1/PPP2R5A/PIK3R1/KRAS/PPP2R5E/GSK3B/MAPK14/PPP3CC/BCL10/MAPK8/FYN/SOS2/PAK2/PIK3CB/PPP3R1	5.61048766903869
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	28/646	158/9376	2.57208919543834	NIPBL/PDS5A/PPP2R5A/ATR/RBX1/ESCO1/CUL1/RBL1/ATRX/EP300/PPP2R5E/CDKN1C/CCNH/STAG1/GSK3B/SMAD2/ABL1/CDK6/PDS5B/SMAD4/CCND3/MCM3/HDAC8/CDC27/HDAC2/MCM6/TFDP2/BUB1	5.42103423365217
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/646	116/9376	2.87776235721149	MMP9/ACTB/ITGB1/ITK/THY1/MYL12A/VAV3/PECAM1/ITGAM/RAC2/CD99/PIK3R1/RAP1A/ROCK1/MAPK14/ACTN4/PTK2B/ITGA4/TXK/RAP1B/ARHGAP35/PIK3CB/ITGAL	5.53552613167733
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	25/646	133/9376	2.72818268581671	KLRC3/KLRC1/KLRC2/SOS1/PPP3CA/LCP2/ZAP70/KLRK1/VAV3/TYROBP/RAC2/BRAF/PIK3R1/KRAS/HCST/PTK2B/PPP3CC/SYK/FYN/SOS2/TNFRSF10A/LAT2/PIK3CB/ITGAL/PPP3R1	5.46013988354113
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/646	93/9376	3.12127567495589	ACTB/PTPN1/MYL12A/LEF1/RAC2/YES1/NLK/EP300/RAP1A/LMO7/IQGAP1/ROCK1/FER/ACTN4/SMAD4/RAP1B/FYN/NECTIN3/WAS/SMURF2	5.59228358323445
Organismal Systems	Immune system	hsa04611	Platelet activation	24/646	126/9376	2.76455845496093	ACTB/PRKACB/LCP2/ITGB1/MYL12A/PPP1R12A/VAMP8/PIK3R1/STIM1/RAP1A/ITPR2/ROCK1/FERMT3/MAPK14/RASGRP2/RAP1B/SYK/FYN/LYN/ARHGAP35/PIK3CG/ITPR1/PIK3CB/GNAQ	5.42431911635444
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/646	67/9376	3.46601358532415	RPS6KA3/PRKACB/PPP3CA/RPS6KA2/BRAF/KRAS/EP300/RAP1A/ITPR2/CAMK2G/PPP3CC/RAP1B/ITPR1/GNAQ/CALM3/PPP3R1	5.51031119510675
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/646	216/9376	2.21740626074991	APOA1/MMP9/LDLR/PPP3CA/CASP8/NFE2L2/VAV3/JAK2/BCL2/IRAK4/POU2F1/PIK3R1/KRAS/HSPA4/RAP1A/TBK1/CAMK2G/GSK3B/MAPK14/ERO1A/MAP2K4/PPP3CC/IRF7/RAP1B/MAPK8/LYN/TNFRSF10A/ITPR1/ERN1/PIK3CB/ATF6/CALM3/PPP3R1	4.92390250264422
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/646	87/9376	3.00288245969894	SOS1/AREG/LEF1/BCL2/RAC2/BRAF/PIK3R1/KRAS/GSK3B/SMAD2/SMAD4/MAPK8/POLK/SOS2/APPL1/EREG/PIK3CB/MSH3	5.10534838599617
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/646	98/9376	2.81392557022809	PTPRC/ARPC2/VAV3/ARPC5L/PLD1/PLPP3/RAC2/ARPC4/ACTR2/PIK3R1/ACTR3/ASAP1/PLPP1/ARF6/CFL1/SYK/LYN/WAS/PIK3CB	4.91021028935801
NA	NA	hsa04517	IgSF CAM signaling	40/646	299/9376	1.94166312890233	CASK/ACTB/CD96/LCP2/ITGB1/MBP/MYL12A/SRGAP2/ARPC2/VAV3/ARPC5L/ITGAM/RAPGEF6/ARPC4/ACTR2/PIK3R1/ACTR3/RAP1A/LMO7/IQGAP1/CABLES1/GSK3B/ABL1/MAPK14/ACTN4/SRGAP3/ARF6/NFASC/ITGA4/RAP1B/NCAM1/MAPK8/FYN/RASA1/LYN/NECTIN3/ERC1/PAK2/PIK3CB/ITGAL	4.50147422342592
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/646	91/9376	2.87088762630558	SOS1/PPP3CA/DAPP1/VAV3/MALT1/RASGRP3/RAC2/PIK3R1/KRAS/GSK3B/PPP3CC/BCL10/SYK/SOS2/LYN/PIK3AP1/PIK3CB/PPP3R1	4.87834173629237
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/646	200/9376	2.17708978328173	ACTB/MYO1E/ITGB1/CYTH1/CASP8/SEC24B/WIPF3/ABI1/ARPC2/ARPC5L/MYO1F/IRAK4/SEC24D/ARPC4/ACTR2/ACTR3/NCKAP1L/ROCK1/HCLS1/ABL1/MAPK14/ARF6/WIPF1/MAPK8/FYN/CYTH4/MYO1G/TMED10/TNFRSF10A/PAK2	4.577123818328
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/646	138/9376	2.41898864809081	RPS6KA3/PRKACB/PPP3CA/RPS6KA2/PPP2R5A/BTRC/RBX1/CUL1/PPP2R5E/ITPR2/CAMK2G/MAPK14/CPEB4/PPP3CC/SLK/FBXW11/CDC27/SPDYE2/BUB1/ITPR1/SPDYA/CALM3/PPP3R1	4.5679807040473
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/646	196/9376	2.14746951412144	EIF2AK2/PREX1/PPP3CA/CASP8/LEF1/JAK2/IRF9/CCR1/PIK3R1/KRAS/EP300/TBK1/ITPR2/GSK3B/CDK6/MAPK14/MAP2K4/PPP3CC/IRF7/PIK3C3/MAPK8/SYK/LYN/PIK3CG/C3/ITPR1/PIK3CB/CALM3/PPP3R1	4.41613790108057
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/646	193/9376	2.10564814963346	PRKACB/PREX1/SOS1/ITK/VAV3/ELMO1/JAK2/RAC2/BRAF/TIAM1/CCR1/PIK3R1/KRAS/RAP1A/ROCK1/GSK3B/DOCK2/PTK2B/RASGRP2/RAP1B/SOS2/LYN/PIK3CG/FGR/WAS/PIK3CB/GNAQ/CCL8	4.22180413700332
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/646	203/9376	2.0734188412207	ACTB/ITGA1/SOS1/ITGB1/MYL12A/VAV3/BCL2/RAC2/PPP1R12A/BRAF/PARVG/PIK3R1/RAP1A/DIAPH1/ROCK1/GSK3B/ACTN4/CCND3/ITGA4/RAP1B/MAPK8/PARVB/FYN/PPP1R12B/SOS2/ZYX/ARHGAP35/PAK2/PIK3CB	4.20587451934427
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	27/646	184/9376	2.12976174451474	PPP3CA/ITGB1/SSH2/SEMA3B/MYL12A/SRGAP2/SEMA4D/RAC2/WNT4/SEMA3A/PIK3R1/KRAS/ROCK1/CAMK2G/GSK3B/ABL1/DPYSL2/SRGAP3/CFL1/PPP3CC/PLXNC1/FYN/RASA1/SEMA4A/PAK2/PIK3CB/PPP3R1	4.21003342404137
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/646	69/9376	2.94485574550186	SOS1/LCP2/VAV3/RAC2/PIK3R1/KRAS/MAPK14/MAP2K4/MAPK8/SYK/FYN/SOS2/LYN/PIK3CB	4.41064250055416
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/646	122/9376	2.37933309648277	ACTB/PRKACB/KAT2B/NCOA2/MED13L/NCOA1/ATP1B3/MED14/WNT4/NCOR1/NCOA3/PIK3R1/KRAS/EP300/GSK3B/TBC1D4/MED13/HDAC2/MED27/PIK3CB	4.17137371437268
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/646	78/9376	2.79114074779709	ACTB/ITGB1/ARPC2/ARPC5L/ELMO1/ARPC4/ACTR2/PIK3R1/ACTR3/CBL/HCLS1/SEPTIN11/SEPTIN6/RHOG/PIK3CB	4.32092790171655
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/646	204/9376	1.99210829842773	MMP9/ACTB/PRKACB/SOS1/LUM/ITGB1/RRAS2/VAV3/PPP1R12A/WNT4/BRAF/TIAM1/PIK3R1/KRAS/IQGAP1/ITPR2/ROCK1/CAMK2G/SMAD2/CBL/DCN/HCLS1/MAPK14/PLAUR/PPP1R12B/SOS2/ITPR1/PIK3CB	3.89705843835565
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/646	170/9376	2.04902567838281	PPP2R2B/ACTB/PRKACB/ITGB1/DLG1/MYL12A/ARPC2/ARPC5L/PATJ/RAPGEF6/TIAM1/ARPC4/ACTR2/HSPA4/ACTR3/RAP1A/RUNX1/ROCK1/MAP3K1/HCLS1/ACTN4/ARHGAP17/MAPK8/WAS	3.75465354981124
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	28/646	212/9376	1.91693440037385	SKAP1/ACTB/FYB1/PRKD3/LCP2/ITGB1/PFN1/VAV3/RASGRP3/EVL/ITGAM/RAC2/DOCK4/BRAF/RAPGEF6/TIAM1/PIK3R1/KRAS/RAP1A/MAPK14/RASGRP2/SIPA1L1/RAP1B/PRKD2/PIK3CB/ITGAL/GNAQ/CALM3	3.67331719599987
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/646	86/9376	2.53149974800202	SOS1/AREG/BRAF/PIK3R1/KRAS/CAMK2G/GSK3B/CBL/ABL1/MAP2K4/MAPK8/SOS2/EREG/PAK2/PIK3CB	3.88108427868231
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	36/646	300/9376	1.74167182662539	RASA2/RPS6KA3/PRKACB/SOS1/PPP3CA/TAOK3/RPS6KA2/RRAS2/AREG/RASGRP3/RAC2/BRAF/IRAK4/NLK/PPM1B/TAOK1/KRAS/RAP1A/MAP3K1/MAPK14/MAP2K4/PPP3CC/RASGRP2/RAP1B/MAP2K5/MAPK8/RPS6KA5/RASA1/STMN1/SOS2/PTPN7/EREG/MAP3K21/PAK2/PPP3R1/DUSP4	3.55156642073821
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/646	214/9376	1.899019125604	PPP3CA/CASP8/ATR/BCL2/RAC2/BTRC/IRAK4/TNFRSF1B/RBX1/CUL1/PIK3R1/SAMHD1/KRAS/TAPBP/TBK1/ITPR2/MAPK14/CFL1/PTK2B/PPP3CC/MAPK8/FBXW11/ITPR1/PAK2/PIK3CB/GNAQ/CALM3/PPP3R1	3.61889055648003
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/646	173/9376	2.01349344118542	MX1/ACTB/EIF2AK2/KPNA1/OAS2/CASP8/JAK2/IRAK4/PRSS3/RSAD2/OAS1/IRF9/PIK3R1/EP300/ADAR/TBK1/CDK6/TRIM25/CCND3/PML/IRF7/HNRNPUL1/TNFRSF10A/PIK3CB	3.65994078076021
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/646	105/9376	2.34987468671679	PPP3CA/RRAS2/CASP8/MALT1/IRF9/PIK3R1/KRAS/ITPR2/MAPK14/PPP3CC/BCL10/MAPK8/SYK/ITPR1/PIK3CB/CALM3/PPP3R1	3.78372520252984
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/646	248/9376	1.81424148606811	PTPRC/ACTB/PFN1/KPNA1/CYTH1/MYL12A/CASP8/ABI1/ARPC2/ARPC5L/ELMO1/LEF1/BCL2/IRAK4/ARPC4/ACTR2/ACTR3/NCKAP1L/PIK3C2A/MAPK14/ARF6/MAP2K4/EXOC4/PIK3C3/MAPK8/CYTH4/PIK3CG/RHOG/SNX18/TNFRSF10A/PIK3CB	3.53497239109285
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/646	125/9376	2.20611764705882	PPP2R2B/PPP2R5A/SGMS1/PLD1/BCL2/RAC2/PIK3R1/KRAS/PPP2R5E/ROCK1/MAPK14/NSMAF/MAPK8/FYN/SGPP1/ASAH1/SPTLC1/PIK3CB/GNAQ	3.69270924048595
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/646	170/9376	1.96364960845019	DPF3/ACTB/SOS1/SMARCA2/NFE2L2/LEF1/ARID1B/WNT4/BRAF/PIK3R1/KRAS/ARID2/GSK3B/SMAD2/CDK6/SMAD4/POLK/SOS2/PBRM1/SMARCB1/SMARCD1/BRD7/PIK3CB	3.44907707952349
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/646	93/9376	2.34095675621692	PRKACB/SOS1/PLD1/KRAS/ITPR2/CAMK2G/MAP3K1/MAPK14/MAP2K4/PTK2B/MAPK8/SOS2/ITPR1/GNAQ/CALM3	3.53514186871309
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	16/646	104/9376	2.23291259823768	ETNK1/SGMS1/PLD1/PLPP3/LCLAT1/SELENOI/AGPAT4/PLPP1/LYPLA1/DGKE/PLAAT2/LPIN1/DGKD/CRLS1/AGPAT5/GNPAT	3.43919676705877
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/646	77/9376	2.45040408507901	PLD1/ARHGEF6/RAC2/BRAF/PIK3R1/KRAS/SMAD2/CDK6/SMAD4/MAPK8/POLK/PIK3CB/BRCA2	3.47625021201275
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/646	77/9376	2.45040408507901	SOS1/BRAF/PIK3R1/KRAS/RUNX1/CBL/ABL1/CDK6/SMAD4/POLK/SOS2/HDAC2/PIK3CB	3.47625021201275
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	21/646	157/9376	1.94135394687543	PPP3CA/RRAS2/SERPINE1/ATR/BTRC/PIK3R1/RBL1/KRAS/IGFBP3/ITPR2/SMAD2/CDK6/MAPK14/CCND3/PPP3CC/FBXW11/MRE11/ITPR1/PIK3CB/CALM3/PPP3R1	3.23560607312619
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	15/646	98/9376	2.22152018702218	PIP4K2A/PIK3R1/ITPR2/PIK3C2A/INPP4A/PIK3C3/DGKE/INPP5B/DGKD/PI4KA/MTMR3/MTMR1/ITPR1/PIK3CB/CALM3	3.30659707841298
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/646	149/9376	1.94817877698589	SOS1/RRAS2/CYTH1/PLD1/PLPP3/PIK3R1/KRAS/AGPAT4/PLPP1/ARF6/PTK2B/DGKE/DGKD/SYK/FYN/SOS2/CYTH4/PIK3CG/AGPAT5/PIK3CB	3.17356852017358
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	25/646	205/9376	1.76999169372499	ISG15/EIF2AK2/OAS2/CASP8/BCL2/IRAK4/OAS1/IRF9/PIK3R1/RBPJ/TAPBP/TBK1/CDK6/MAPK14/MAP2K4/CCND3/IRF7/MAPK8/SYK/POLK/LYN/HDAC2/CD58/PIK3CB/ITGAL	3.03214104537339
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/646	205/9376	1.76999169372499	SP100/RASA2/PRKACB/EIF2AK2/HDAC9/KAT2B/DLG1/CASP8/IRF9/PIK3R1/RBL1/KRAS/EP300/RBPJ/CDK6/ACTN4/CCND3/IRF7/SYK/HDAC4/HDAC8/LYN/HDAC2/C3/PIK3CB	3.03214104537339
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/646	55/9376	2.63889670700816	B4GALT5/SGMS1/PLPP3/B4GALT6/PLPP1/ACER3/GALC/SGPP1/ASAH1/SPTLC1	3.31586200760585
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/646	73/9376	2.38585181729505	MX1/KAT2B/MDFIC/SAMHD1/EP300/PDCD6IP/ELL/PSIP1/CPSF6/SMARCB1/NUP153/CCNT2	3.23341531187246
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/646	163/9376	1.86989306539535	MMP9/SOS1/STAT4/CASP8/JAK2/BCL2/BRAF/IRAK4/PIK3R1/KRAS/EP300/TBK1/MAP3K1/MAPK14/SMAD4/MAP2K4/PTK2B/IRF7/MAPK8/SOS2/PIK3CB	3.04757155048001
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/646	122/9376	2.02243313201035	PRKACB/SOS1/JAK2/PIK3R1/KRAS/EP300/IGFBP3/ITPR2/GSK3B/MAP3K1/MAPK14/MAP2K4/MAPK8/SOS2/ITPR1/PIK3CB/GNAQ	3.09203824837317
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/646	56/9376	2.59177355152587	PRKACB/BCL2/BTRC/CUL1/CSNK1G1/GSK3B/SPOP/FBXW11/SMURF2/SPOPL	3.24984102650131
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/646	156/9376	1.8607604985314	PPP2R2B/MX1/LDLR/EIF2AK2/SOS1/PIAS1/OAS2/CASP8/BRAF/RSAD2/OAS1/IRF9/PIK3R1/KRAS/TBK1/GSK3B/CDK6/IRF7/SOS2/PIK3CB	2.94899436308027
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/646	136/9376	1.92096157348388	MX1/EIF2AK2/OAS2/CASP8/BCL2/IRAK4/OAS1/IRF9/PIK3R1/ADAR/TBK1/GSK3B/CDK6/CCND3/IRF7/MAPK8/PIK3CB/IL2RA	2.94286102891679
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/646	117/9376	1.98481119843349	DPF3/ACTB/SMARCA2/ARID1B/ARID2/PHF6/CHD3/PBRM1/SMARCB1/SMARCD1/HDAC2/BAZ2B/BAZ1B/BRD7/RSF1/MTA3	2.91580611583978
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/646	68/9376	2.34784192314697	SOS1/LEF1/ITGAM/BRAF/PIK3R1/KRAS/PIM1/RUNX1/PML/SOS2/PIK3CB	3.0343103948744
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/646	99/9376	2.0524752165619	SOS1/PLD1/PLPP3/RAC2/PIK3R1/KRAS/PLPP1/LYPLA1/DGKE/MAPK8/DGKD/SOS2/WAS/PIK3CB	2.86365353172846
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/646	70/9376	2.28076072534277	SOS1/BRAF/RBX1/PIK3R1/KRAS/EP300/RAP1A/RAP1B/SOS2/PAK2/PIK3CB	2.92570324019683
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/646	110/9376	1.97917253025612	RPS6KA3/PRKACB/RPS6KA2/BRAF/PIK3R1/KRAS/MAPK14/CPEB4/MAPK8/STK10/CDC27/SPDYE2/BUB1/SPDYA/PIK3CB	2.8099862270631
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/646	71/9376	2.24863733484498	PRL/SOS1/PRLR/JAK2/PIK3R1/KRAS/GSK3B/MAPK14/MAPK8/SOS2/PIK3CB	2.87277807346788
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/646	133/9376	1.85516422635536	PPP2R2B/PRKACB/PPP3CA/CLOCK/PPP2R5A/MAOA/PPP2R5E/ITPR2/CAMK2G/GSK3B/MAPK14/PPP3CC/MAPK8/COMT/ITPR1/GNAQ/CALM3	2.70186499241188
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	11/646	72/9376	2.21740626074991	ISG15/CASP8/ADAR/TBK1/MAP3K1/ZNFX1/MAPK14/TRIM25/IRF7/MAPK8/ATG5	2.82073120837483
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/646	20/9376	3.62848297213622	MSMO1/FDFT1/SQLE/DHCR24/SOAT1	3.20088325499997
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	21/646	178/9376	1.71231780707552	PRKACB/PPP3CA/TBL1XR1/LEF1/LGR4/INVS/RAC2/BTRC/WNT4/NLK/RBX1/CUL1/EP300/CAMK2G/GSK3B/SMAD4/CCND3/PPP3CC/MAPK8/FBXW11/PPP3R1	2.60994812350058
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/646	83/9376	2.09839979111492	SFMBT2/MBD5/AUTS2/L3MBTL4/YAF2/EP300/ASXL2/SFMBT1/CBX4/HDAC2/CBX3/PHC3	2.73411195962277
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	26/646	238/9376	1.58555558446289	RASA2/PRKACB/SOS1/RRAS2/ZAP70/RASGRP3/PLD1/RAC2/ETS2/TIAM1/PIK3R1/KRAS/RAP1A/TBK1/ABL1/ARF6/PLAAT2/RASGRP2/RAP1B/MAPK8/RASA1/SOS2/PAK2/PIK3CB/CALM3/RALGAPA1	2.48900520168407
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/646	138/9376	1.78794813119756	PRKACB/SOS1/PTPN1/BRAF/PIK3R1/KRAS/PRKAR2A/GSK3B/CBL/EIF4E/PRKAR1A/MAPK8/SOS2/ACACA/HKDC1/PIK3CB/CALM3	2.53654732470433
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/646	139/9376	1.77508519500189	MMP9/PRKACB/FKBP5/SOS1/NCOA2/NCOA1/BCL2/NCOA3/PIK3R1/KRAS/ITPR2/SOS2/ITPR1/KRT23/PIK3CB/GNAQ/CALM3	2.50429879833412
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/646	99/9376	1.90586984395034	MMP9/PRKACB/SOS1/BCL2/BRAF/NCOR1/NCOA3/PIK3R1/KRAS/MAPK14/MAPK8/SOS2/PIK3CB	2.4647586347817
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/646	187/9376	1.62990678962269	OAS2/CASP8/BCL2/IRAK4/PKN2/OAS1/IRF9/TBK1/ITPR2/NEK7/ATG16L1/IFI16/MAPK14/CARD16/IRF7/DNM1L/MAPK8/MFN1/ITPR1/ATG5/ANTXR2	2.36677919172477
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/646	59/9376	2.21398961011702	SOS1/LEF1/BRAF/PIK3R1/KRAS/GSK3B/POLK/SOS2/PIK3CB	2.54447215896461
NA	NA	hsa04518	Integrin signaling	18/646	154/9376	1.69643359736239	ACTB/ITGA1/ITGB1/ITGAM/ITGAD/ARHGEF6/RAC2/PARVG/PIK3R1/GSK3B/FERMT3/ACTN4/CCND3/ITGA4/PARVB/C3/PIK3CB/ITGAL	2.37040356160925
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/646	180/9376	1.61265909872721	SP100/EIF2AK2/ZC3HAV1/OAS2/CASP8/JAK2/BCL2/IRAK4/POU2F1/OAS1/IRF9/PIK3R1/TAPBP/TBK1/PML/IRF7/SYK/SRSF4/C3/PIK3CB	2.2576178712588
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	19/646	169/9376	1.63174382178907	PRKACB/BIRC6/RRAS2/BCL2/VAMP8/PIK3R1/KRAS/TBK1/ATG16L1/PIK3C3/MAPK8/ATG7/MTMR3/ATG2B/UVRAG/ITPR1/ERN1/ATG5/PIK3CB	2.2543433347197
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/646	227/9376	1.53451262257743	PRKACB/SOS1/PPP3CA/CASP8/RAC2/CCR1/PIK3R1/KRAS/AKAP13/TAPBP/TBK1/ITPR2/ROCK1/GSK3B/CDK6/MAPK14/PTK2B/PPP3CC/SOS2/ITPR1/PIK3CB/GNAQ/CALM3/PPP3R1	2.21757775128294
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/646	62/9376	2.10686108059523	MAML3/KAT2B/ITCH/EP300/RBPJ/DTX3L/SPEN/NUMB/HDAC2	2.37856826588671
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/646	93/9376	1.87276540497353	PPP3CA/STAT4/MAML3/ZAP70/JAK2/RBPJ/MAPK14/PPP3CC/MAPK8/GATA3/IL2RA/PPP3R1	2.30085684000028
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/646	115/9376	1.76691344730112	MEF2A/PRKACB/STK39/PLD1/BCL2/BRAF/AKAP13/WNK1/ITPR2/SGK1/GATA3/OXSR1/ITPR1/GNAQ	2.2509254229537
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/646	76/9376	1.9097278800717	SOS1/BRAF/PIK3R1/KRAS/CAMK2G/CDK6/POLK/SOS2/PIK3CB/CALM3	2.16606558272658
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/646	154/9376	1.60218728639781	ACTB/PRKACB/PPP3CA/PPP1R12A/KRAS/ITPR2/ROCK1/CAMK2G/PPP3CC/MAP2K5/PPP1R12B/PIK3CG/ITPR1/CD38/GNAQ/CALM3/PPP3R1	2.04962381745983
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/646	110/9376	1.71528285955531	NCOR1/RBX1/CUL1/RBL1/EP300/ROCK1/SMAD2/LEMD3/DCN/SMAD4/ZFYVE16/HDAC2/SMURF2	2.05268726572525
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/646	37/9376	2.35361057652079	LEF1/BRAF/TPM3/KRAS/POLK/NCOA4	2.24408441068743
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/646	78/9376	1.8607604985314	PIP4K2A/PIK3C2A/INPP4A/PIK3C3/INPP5B/PI4KA/MTMR3/MTMR1/PIK3CG/PIK3CB	2.07648899695575
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/646	78/9376	1.8607604985314	ZCCHC7/DHX36/XRN1/PAN3/BTG3/CNOT10/CNOT7/CNOT6/PARN/DCP1A	2.07648899695575
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/646	181/9376	1.52356191095223	PPP3CA/CASP8/MALT1/JAK2/ITGAM/BCL2/IRAK4/EP300/CAMK2G/CORO1A/MAPK14/PPP3CC/PIK3C3/BCL10/MAPK8/SYK/C3/CALM3/PPP3R1	1.93475616933553
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/646	158/9376	1.5616255829447	RPS6KA3/SOS1/RPS6KA2/ATP6V1A/WNT4/BRAF/PIK3R1/RICTOR/KRAS/GSK3B/FNIP1/EIF4E/LPIN1/SOS2/SGK1/CAB39/PIK3CB	1.93665316222035
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/646	101/9376	1.72442755111424	SERPINE1/JAK2/BCL2/PIK3R1/KRAS/DIAPH1/PIM1/SMAD2/MAPK14/SMAD4/MAPK8/PIK3CB	1.99110178612724
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/646	69/9376	1.89312155067977	PRKACB/PPP3CA/REN/ITPR2/PPP3CC/ITPR1/GNAQ/CALM3/PPP3R1	2.02546635075627
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/646	80/9376	1.81424148606811	SOS1/JAK2/BCL2/BRAF/PIK3R1/KRAS/GSK3B/EIF4E/SOS2/PIK3CB	1.98950455348356
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/646	103/9376	1.69094352099552	PPP2R2B/SERPINE1/CASP8/IRAK4/PIK3R1/SMAD2/MAPK14/MAP2K4/MAPK8/C3/PIK3CB/GNAQ	1.9179876508421
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/646	60/9376	1.93519091847265	PPP3CA/RAC2/PIK3R1/KRAS/MAPK14/PPP3CC/PIK3CB/PPP3R1	1.97676908932198
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/646	115/9376	1.64070534392247	PRKACB/KCNQ5/JAK2/BCL2/PIK3R1/KRAS/ITPR2/CAMK2G/FYN/PIK3CG/ITPR1/PIK3CB/GNAQ	1.88049896938516
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/646	333/9376	1.35114681244712	ISG15/PPP2R2B/MX1/PRKACB/ITGA1/EIF2AK2/SOS1/MAML3/ITGB1/DLG1/CASP8/PPP2R5A/ATR/ATP6V1A/PATJ/WNT4/IRF9/PIK3R1/RBL1/KRAS/EP300/RBPJ/PPP2R5E/TBK1/GSK3B/CDK6/CCND3/ITGA4/SOS2/HDAC2/PIK3CB	1.77479974284014
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/646	224/9376	1.42547545333923	PRKACB/PPP3CA/KAT2B/DLG1/ATR/ETS2/PIK3R1/KRAS/EP300/SMAD2/MAP3K1/SMAD4/TSPO/MAP2K4/CCND3/PPP3CC/MAPK8/CDC27/PIK3CB/ITGAL/IL2RA/PPP3R1	1.75321544722701
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/646	41/9376	2.12399003246998	RAD51B/MRE11/BABAM2/BARD1/TOPBP1/BRCA2	1.96196837406619
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/646	106/9376	1.64308662889187	MMP9/SOS1/LEF1/BCL2/BRAF/PIK3R1/KRAS/EP300/GSK3B/SOS2/ZEB1/PIK3CB	1.81124550504952
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/646	201/9376	1.4441723272184	MMP9/FUT8/FLI1/JMJD1C/KMT2A/ITGAM/NCOR1/NSD2/KDM6A/IGFBP3/RUNX1/PBX3/PML/HPGD/POLK/BMP2K/TAF15/HDAC2/ZEB1/CCNT2	1.73157483378608
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/646	73/9376	1.78938886297129	EML4/SOS1/BRAF/PIK3R1/KRAS/CDK6/POLK/SOS2/PIK3CB	1.84177125194731
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/646	107/9376	1.62773067908915	PRKACB/PPP3CA/SIK2/EP300/ITPR2/CAMK2G/PPP3CC/ACACA/ITPR1/GNAQ/CALM3/PPP3R1	1.77641150631103
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/646	32/9376	2.26780185758514	ATG16L1/PIK3C3/ATG7/ATG2B/ATG5	1.9541357651377
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/646	63/9376	1.84303896997395	KMT2C/PRDM2/SETD2/KMT2A/NSD2/NSD1/ASH1L/SMYD3	1.82628225446097
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/646	23/9376	2.52416206757302	IDI1/PDSS2/PDSS1/MVD	1.99073923136143
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/646	168/9376	1.468671679198	PRL/SOS1/STAT4/PRLR/PIAS1/JAK2/STAM/BCL2/IRF9/PIK3R1/EP300/PIM1/CCND3/SOS2/PIK3CB/IL2RA/PIAS2	1.66738339338713
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/646	109/9376	1.59786406112421	PPP3CA/ZAP70/JAK2/RUNX1/SMAD2/MAPK14/SMAD4/PPP3CC/MAPK8/GATA3/IL2RA/PPP3R1	1.70781526321593
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/646	75/9376	1.74167182662539	COP1/SERPINE1/CASP8/ATR/BCL2/IGFBP3/CDK6/CCND3/TNFRSF10A	1.75417277709573
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/646	98/9376	1.62911480381626	PRKACB/LDLR/PRKD3/ATP2B4/ATP1B3/ITPR2/CAMK2G/PRKD2/ITPR1/GNAQ/CALM3	1.70298386746796
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/646	65/9376	1.78633007859014	PLPP3/LCLAT1/AGPAT4/PLPP1/DGKE/LPIN1/DGKD/AGPAT5	1.73044650832658
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/646	99/9376	1.61265909872721	PRKACB/PIK3R1/PRKCH/ITPR2/CAMK2G/MAPK14/MAPK8/ITPR1/PIK3CB/GNAQ/CALM3	1.6669688408882
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/646	44/9376	1.97917253025612	FUT8/MAN1A1/B4GALNT3/ST3GAL3/MAN2A1/MAGT1	1.77089564444237
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/646	34/9376	2.13440174831543	CLOCK/BTRC/RBX1/CUL1/FBXW11	1.80252455466788
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/646	78/9376	1.67468444867826	ITGB1/ITGAM/SERPING1/IRAK4/MAPK14/CFL1/MAPK8/C3/CALM3	1.62760121600359
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/646	137/9376	1.48317552145714	ACTB/LMNB1/CASP8/BCL2/PIK3R1/KRAS/PARP4/ITPR2/PARP1/MAPK8/TNFRSF10A/ITPR1/ERN1/PIK3CB	1.54969952312719
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/646	90/9376	1.61265909872721	EML4/PPP3CA/ZAP70/JAK2/PIK3R1/KRAS/MAPK14/PPP3CC/PIK3CB/PPP3R1	1.58862202018659
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/646	174/9376	1.41802782819117	SEC24B/NFE2L2/MAN1A1/BCL2/SEC24D/RBX1/CUL1/DNAJA2/ERO1A/MAGT1/SEC31A/TRAM1/MAPK8/UBQLN1/UBE2J1/ERN1/ATF6	1.51402650745719
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/646	36/9376	2.01582387340901	B4GALT5/GALNT3/GALNT10/GALNT1/C1GALT1	1.66108173494472
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/646	36/9376	2.01582387340901	PRIM2/POLA1/POLE4/MCM3/MCM6	1.66108173494472
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/646	69/9376	1.68277471171535	PRKACB/PPP3CA/MAOA/CAMK2G/PPP3CC/HDAC2/CALM3/PPP3R1	1.54843112079669
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/646	140/9376	1.45139318885449	MEF2A/PRKACB/RRAS2/SERPINE1/KRAS/ITPR2/SMAD2/SMAD4/PIK3C3/HDAC4/PIK3CG/ITPR1/GNAQ/CALM3	1.46376659811649
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/646	70/9376	1.65873507297656	ACTB/CASP8/SNTB1/RAC2/ABL1/EIF4G3/FYN/ITGAL	1.5047801664304
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/646	154/9376	1.41369466446866	PPP2R2B/PRKACB/PPP2R5A/ATP2B4/ATP1B3/BCL2/TPM3/PPP2R5E/CAMK2G/MAPK14/RPS6KA5/PIK3CG/GNAQ/TPM4/CALM3	1.408064329161
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	14/646	142/9376	1.43095103126499	PPP3CA/LCP2/TYROBP/IRF9/PIK3R1/ITPR2/MAPK14/PPP3CC/MAPK8/SYK/FYN/ITPR1/PIK3CB/PPP3R1	1.40757627060877
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/646	142/9376	1.43095103126499	MEF2A/MMP9/ACTB/NFE2L2/PECAM1/BCL2/RAC2/PIK3R1/MAPK14/MAP2K4/MAP2K5/MAPK8/PIK3CB/CALM3	1.40757627060877
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/646	155/9376	1.40457405373015	PRKACB/LDLR/LEF1/KMT2A/WNT4/BRAF/RAP1A/ITPR2/CAMK2G/GSK3B/CDK6/USP8/RAP1B/ITPR1/GNAQ	1.3815596492044
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/646	38/9376	1.9097278800717	ATP1B3/PIK3R1/KRAS/SGK1/PIK3CB	1.52852006255631
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/646	49/9376	1.77721614961774	GALNT3/ST3GAL3/GALNT10/GALNT1/GXYLT1/C1GALT1	1.48375994587581
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/646	157/9376	1.38668139062531	PPP2R2B/ACTB/SERPINE1/AREG/DLG1/LEF1/BTRC/PATJ/WNT4/GSK3B/SMAD2/SMAD4/CCND3/FBXW11/LIMD1	1.32909482137402
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/646	109/9376	1.46470872269719	RPS6KA3/RPS6KA2/PTPN1/GFPT1/PIK3R1/OGA/GSK3B/TBC1D4/MAPK8/SLC27A2/PIK3CB	1.32745334797263
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/646	51/9376	1.70752139865234	PLD1/PLPP3/SELENOI/PLPP1/PLAAT2/AGPS	1.37814534523004
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/646	148/9376	1.37293950297046	SOS1/NCOA1/LEF1/WNT4/BRAF/NCOA3/PIK3R1/KRAS/GSK3B/CDK6/POLK/SOS2/PIK3CB/BRCA2	1.24397091921719
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	20/646	226/9376	1.28441875119866	PRKACB/RRAS2/VAV3/ATP2B4/PLD1/ATP1B3/RAC2/PPP1R12A/BRAF/TIAM1/PIK3R1/EP300/RAP1A/ROCK1/CAMK2G/RAP1B/MAPK8/ACOX1/PIK3CB/CALM3	1.17732583207183
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/646	76/9376	1.52778230405736	ACTB/PRKACB/ATP1B3/ITPR2/CAMK2G/ITPR1/GNAQ/CALM3	1.25665169665975
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/646	102/9376	1.42293449887695	ATP2B4/ATP1B3/CPB1/PRSS3/RAP1A/ITPR2/RAP1B/ITPR1/CD38/GNAQ	1.16824633584214
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/646	21/9376	2.0734188412207	XYLT1/CHSY1/CHST12	1.33952782953682
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/646	21/9376	2.0734188412207	DPYD/AASDHPPT/PANK3	1.33952782953682
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/646	32/9376	1.81424148606811	HIBCH/SUCLG2/ACACA/ACOX1	1.25503713365376
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/646	32/9376	1.81424148606811	BIRC6/CASP8/BCL2/MAPK8	1.25503713365376
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/646	194/9376	1.27183939229517	ACTB/MYO1E/MYL12A/MYO1F/CAPZA1/TPM3/KIF1B/KIFAP3/STARD9/KIF20B/CAPZB/HOOK3/MYO1G/KIF21A/KIF18A/TPM4/MYO9A	1.04073314658789
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/646	44/9376	1.6493104418801	MNAT1/GTF2I/CCNH/TAF2/TAF15	1.17431912955692
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/646	105/9376	1.38227922748047	ZAP70/MALT1/BCL2/IRAK4/TRIM25/BCL10/PARP1/SYK/LYN/ERC1	1.07153616676786
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/646	105/9376	1.38227922748047	RRAS2/USP15/KRAS/TBK1/USP8/MAPK8/MFN1/MON1B/CITED2/SMURF2	1.07153616676786
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/646	93/9376	1.40457405373015	PRKACB/ATP2B4/ATP1B3/ITPR2/LYZ/ITPR1/CD38/GNAQ/CALM3	1.06657181128746
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/646	144/9376	1.31028551771586	CASP8/LEF1/IRAK4/TBK1/GSK3B/MAPK14/MAP2K4/LPIN1/MAPK8/ADIPOR2/ACACA/C3/ACOX1	1.02068005712976
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/646	144/9376	1.31028551771586	ATXN10/PIK3R1/RBPJ/ITPR2/ATXN2/PIK3C3/NOP56/MAPK8/ATG2B/ITPR1/ERN1/PIK3CB/GNAQ	1.02068005712976
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/646	157/9376	1.29423596458362	CD47/XKR6/ATP8A1/ADAM10/VPS8/ATP11B/PECAM1/ELMO1/JAK2/ATP11A/CAMK2G/MAPK14/SGK1/DUSP4	1.01134294608199
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/646	119/9376	1.34162395608398	MMP9/ITCH/CASP8/TNFRSF1B/PIK3R1/MAPK14/MAP2K4/DNM1L/MAPK8/RPS6KA5/PIK3CB	1.0201908916278
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/646	133/9376	1.30952768919202	SOS1/BRAF/NLK/PIK3R1/KRAS/EP300/MAPK14/SMAD4/MAPK8/SOS2/SGK1/PIK3CB	0.9779431854561
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/646	23/9376	1.89312155067977	ATP1B3/GLUD1/MDH1	1.16652431335186
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/646	83/9376	1.39893319407662	CASP8/SAMHD1/ZBP1/ADAR/TBK1/IFI16/IRF7/POLR3K	0.993015499309455
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/646	109/9376	1.33155338427017	CASP8/IRAK4/IRF9/PIK3R1/TBK1/MAPK14/MAP2K4/IRF7/MAPK8/PIK3CB	0.947091432729324
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/646	362/9376	1.16271830046354	PRL/PPP2R2B/ITGA1/SOS1/ITGB1/PRLR/AREG/PPP2R5A/JAK2/BCL2/PHLPP1/THEM4/PKN2/PIK3R1/KRAS/PPP2R5E/GSK3B/CDK6/EIF4E/CCND3/ITGA4/SYK/SOS2/SGK1/PIK3CG/EREG/PIK3AP1/PIK3CB/IL2RA	0.858868516832507
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/646	13/9376	2.23291259823768	DCLRE1C/MRE11	1.21001632635478
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/646	60/9376	1.45139318885449	BRAF/KRAS/ITPR2/LYN/ITPR1/GNAQ	0.95413683477095
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/646	150/9376	1.25787409700722	SOS1/LEF1/BCL2/WNT4/BRAF/PIK3R1/KRAS/GSK3B/SMAD2/SMAD4/POLK/SOS2/PIK3CB	0.866046877015022
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/646	14/9376	2.0734188412207	FUT8/ST3GAL3	1.09331092732761
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/646	166/9376	1.22406654481704	MEF2A/PPP3CA/ATP2B4/ATP1B3/PPP1R12A/GTF2I/ITPR2/ROCK1/PPP3CC/PIK3CG/ITPR1/GNAQ/CALM3/PPP3R1	0.792311613055362
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/646	62/9376	1.40457405373015	PRKACB/PIK3R1/KRAS/HDAC2/ATG5/PIK3CB	0.869401790589829
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/646	88/9376	1.31944835350408	CLU/SERPINE1/ITGAM/SERPING1/PLAUR/TFPI/CFH/C3	0.818984461643338
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/646	101/9376	1.29332066333568	PRKACB/LEF1/WNT4/KRAS/EP300/CAMK2G/GSK3B/GNAQ/CALM3	0.806196969976369
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/646	63/9376	1.38227922748047	MNAT1/RBX1/POLR2J/POLR2J3/CCNH/POLE4	0.828134634651816
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/646	168/9376	1.20949432404541	EIF2AK2/STAT4/CASP8/JAK2/BCL2/IRF9/ZBP1/CAMK2G/GLUD1/CHMP5/DNM1L/PARP1/MAPK8/TNFRSF10A	0.745313558352663
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/646	89/9376	1.30462309110516	PRKACB/SOS1/KRAS/ITPR2/MAP2K5/SOS2/ITPR1/GNAQ	0.785443367276209
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/646	90/9376	1.29012727898177	PRKACB/PIK3R1/KRAS/EIF4E/ADIPOR2/APPL1/ATG5/PIK3CB	0.752298602933951
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/646	130/9376	1.22810192903072	MMP9/PRKACB/SOS1/PIK3R1/KRAS/SMAD2/MAPK14/MAP2K4/MAPK8/SOS2/PIK3CB	0.712391067014828
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/646	27/9376	1.61265909872721	ELOVL5/ACOX1/HACD1	0.867187412317252
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/646	65/9376	1.33974755894261	PIK3R1/KRAS/ITPR2/ITPR1/PIK3CB/GNAQ	0.747669449627082
NA	NA	hsa04519	Cadherin signaling	31/646	404/9376	1.11369279342795	ACTB/MYO1E/TAOK3/RRAS2/ADAM10/ARPC2/VAV3/ARPC5L/LEF1/MYO1F/EVL/RAC2/WNT4/ARPC4/ACTR2/TAOK1/KRAS/ACTR3/EP300/NCKAP1L/ROCK1/GSK3B/MAPK14/ACTN4/PTK2B/KRT86/MAPK8/ARHGAP35/MYO1G/LIMD1/KRT23	0.635438848670973
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/646	78/9376	1.30253234897198	ITGB1/JAK2/ITGAM/IRAK4/MAPK14/ITGA4/C3	0.729825654099268
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/646	105/9376	1.24405130473242	ACTB/PRKACB/ITGA1/ITGB1/SNTB1/TPM3/TTN/ITGA4/TPM4	0.684080590230435
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/646	28/9376	1.55506413091552	THEM4/ELOVL5/HACD1	0.800124562299655
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/646	160/9376	1.17925696594427	PTPRC/ITGB1/GLG1/PECAM1/ITGAM/CD99/SPN/NFASC/ITGA4/NCAM1/NECTIN3/CD58/ITGAL	0.622099102845549
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/646	41/9376	1.41599335497999	MMP9/BRAF/KRAS/RPS6KA5	0.726132601459903
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/646	54/9376	1.34388258227268	ATR/FANCI/POLK/FANCL/BRCA2	0.68936191317121
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/646	17/9376	1.70752139865234	GLUD1/CA5B	0.794225984783601
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/646	122/9376	1.18966654824138	PPP2R2B/PPP2R5A/TBC1D1/PIK3R1/PPP2R5E/RAB10/ADIPOR2/CAB39/ACACA/PIK3CB	0.573588827707646
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/646	205/9376	1.13279468398399	MMP9/REN/RAC2/GFPT1/PIK3R1/CAMK2G/GSK3B/SMAD2/TBC1D4/MAPK14/NDUFB3/PARP1/MAPK8/COX8A/G6PD/PIK3CB	0.522930591585138
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/646	233/9376	1.12124795705497	ACTB/ITGA1/FBN2/ITGB1/LMNB1/ATP1B3/SNTB1/CAPZA1/TPM3/DIAPH1/TTN/DCN/ITGA4/FMNL3/CAPZB/ZYX/NID2/TPM4	0.509803491783506
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/646	30/9376	1.45139318885449	SUCLG2/MDH1/IDH2	0.673592923532773
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/646	56/9376	1.29588677576294	MGAT5/FUT8/MAN1A1/MAN2A1/MAGT1	0.604096595367985
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/646	110/9376	1.18750351815367	SERPINE1/BCL2/RBX1/PIK3R1/EP300/CAMK2G/EIF4E/HKDC1/PIK3CB	0.538089343049564
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/646	31/9376	1.40457405373015	HIBCH/DPYD/ACOX1	0.613739388697821
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/646	250/9376	1.10305882352941	OSBPL3/BORCS5/AP3B1/ATP6V1A/WDR7/VAMP8/BORCS7/VPS13C/GNS/ARSB/GALC/ASAH1/SUMF1/MANBA/VPS13A/GPR155/MFSD8/SPG11/DTNBP1	0.449272387969139
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/646	71/9376	1.22652945536999	ADAM10/ATP6V1A/MAPK14/MAP2K4/MAPK8/LYN	0.52118324049819
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/646	71/9376	1.22652945536999	PIK3R1/KRAS/HKDC1/IDH2/G6PD/PIK3CB	0.52118324049819
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/646	112/9376	1.16629809818664	LDLR/ITGB1/CASP8/JAK2/BCL2/IRAK4/MAPK14/MAPK8/PIK3CG	0.481605897100188
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/646	99/9376	1.17284298089252	ACTB/ITGA1/ITGB1/SNTB1/TPM3/TTN/ITGA4/TPM4	0.470284150047933
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/646	19/9376	1.52778230405736	GNS/ARSB	0.626409139823241
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/646	73/9376	1.19292590864753	BRAF/PIK3R1/KRAS/CDK6/POLK/PIK3CB	0.450127192022151
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/646	227/9376	1.08694644099235	SOS1/PRKD3/PTPN1/NFE2L2/PLD1/BRAF/PIK3R1/KRAS/ABL1/MAPK14/MAP2K4/NDUFB3/MAPK8/COX8A/SOS2/PRKD2/PIK3CB	0.360722057728273
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/646	33/9376	1.31944835350408	STX16/VTI1A/VAMP8	0.500045156381459
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/646	20/9376	1.45139318885449	GMDS/CYB5R4	0.549692318703174
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/646	47/9376	1.23522824583361	PIK3R1/MAPK8/HKDC1/PIK3CB	0.439759902531515
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/646	75/9376	1.16111455108359	CASP8/BCL2/PIK3R1/TOP2B/PIK3CB/MSH3	0.381061743697035
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/646	34/9376	1.28064104898926	POLR2J/POLR2J3/POLR3K	0.445928774882517
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/646	48/9376	1.20949432404541	ATP1B3/PIK3R1/HKDC1/PIK3CB	0.395816036960324
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/646	35/9376	1.24405130473242	GMDS/ENOSF1/HKDC1	0.393471467693101
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/646	134/9376	1.0831292454138	PRKACB/PPP1R12A/BRAF/PRKCH/ITPR2/ROCK1/PPP1R12B/ITPR1/GNAQ/CALM3	0.263644084154977
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/646	50/9376	1.16111455108359	KLRB1/KLRK1/PECAM1/ITGAL	0.310718303853921
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/646	65/9376	1.11645629911884	PRKACB/LDLR/ITPR2/ITPR1/GNAQ	0.256280920277333
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/646	108/9376	1.07510606581814	KPNA1/IPO11/POM121/UPF2/XPO6/NUP210/NUP153/THOC2	0.21354462966572
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/646	51/9376	1.13834759910156	ACTB/PRKACB/ATP6V1A/ERO1A	0.269480329624989
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/646	94/9376	1.08082471510441	MMP9/USP25/CASP8/TBK1/GSK3B/MAPK14/MAPK8	0.21423089519608
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/646	37/9376	1.1768052882604	GMDS/GFPT1/HKDC1	0.293116792964242
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/646	238/9376	1.03670942061035	ISG15/MX1/EIF2AK2/OAS2/RPL36AL/IRAK4/OAS1/IRF9/PIK3R1/ADAR/TBK1/MAPK14/RPL28/MAPK8/SYK/C3/PIK3CB	0.156039736063279
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/646	195/9376	1.04202587917758	ACTB/HDAC9/ITGAM/RAC2/PIK3R1/MAPK14/SYK/ATG7/HDAC4/HDAC8/HDAC2/C3/PIK3CB/ITGAL	0.161318395926019
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/646	23/9376	1.26208103378651	LNPEP/REN	0.342309395342286
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/646	52/9376	1.11645629911884	APOA1/LDLR/TSPO/SOAT1	0.229064769516341
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/646	38/9376	1.14583672804302	PTPRC/ZAP70/DCLRE1C	0.245034113556851
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/646	24/9376	1.20949432404541	XYLT1/EXT2	0.279524840277093
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/646	82/9376	1.06199501623499	KLRC3/KLRC1/KLRC2/KLRC4/HSPA4/TAPBP	0.153375907550164
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/646	53/9376	1.09539108592792	PRKACB/ATP2B4/ATP1B3/GNAQ	0.189436063667834
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/646	83/9376	1.04919989555746	PEX14/AGPS/SLC27A2/IDH2/ACOX1/GNPAT	0.122467269152798
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/646	157/9376	1.01689968645856	ITCH/CASP8/PIK3R1/GSK3B/MAPK14/NDUFB3/MAPK8/COX8A/ADIPOR2/ERN1/PIK3CB	0.0580873202059021
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/646	70/9376	1.03670942061035	JAK2/TNFRSF1B/MAPK8/ADIPOR2/APPL1	0.0838570926639743
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/646	85/9376	1.0245128391914	NT5C3A/NME7/CDA/GMPS/ADK/IMPDH1	0.0617542176828702
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/646	144/9376	1.00791193670451	JAK2/WNT4/PIK3R1/KRAS/SMARCAD1/GSK3B/SMAD2/MAPK14/SMAD4/PIK3CB	0.0260262098824658
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/646	115/9376	1.00966482702921	PRKACB/MAOA/BRAF/KRAS/ITPR2/KCND2/ITPR1/GNAQ	0.0283667015424712
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/646	26/9376	1.11645629911884	PLAAT2/ACOX1	0.161747891627557
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/646	26/9376	1.11645629911884	APOA1/LMBRD1	0.161747891627557
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/646	86/9376	1.01259989920081	ACTB/ITGA1/ITGB1/LEF1/SNTB1/ITGA4	0.0319303158652345
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/646	116/9376	1.00096081989965	HIBCH/SUCLG2/GLUD1/MDH1/HKDC1/IDH2/G6PD/ACOX1	0.00283243704503366
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/646	116/9376	1.00096081989965	PRKACB/PPP3CA/PLD1/ITPR2/PPP3CC/ITPR1/GNAQ/PPP3R1	0.00283243704503366
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/646	57/9376	1.01852153603824	ACACA/ELOVL5/ACOX1/HACD1	0.0381526359278243
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/646	42/9376	1.03670942061035	ATG7/ATG5/NCOA4	0.0648579253175875
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/646	103/9376	0.986383720580721	PPP2R2B/PPP2R5A/UPF2/PPP2R5E/CPSF6/MSI2/RNGTT	-0.0377973813821495
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/646	12/9376	1.20949432404541	NCAM1	0.197527222367609
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/646	43/9376	1.01259989920081	APOA1/PLPP3/PLPP1	0.0225260706038394
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/646	59/9376	0.98399538227423	DPYD/NT5C3A/NME7/CDA	-0.0335450187371603
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/646	59/9376	0.98399538227423	PRKACB/PIK3R1/PLAAT2/PIK3CB	-0.0335450187371603
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/646	44/9376	0.989586265128061	PARP4/PARP1/POLE4	-0.0188339002139601
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/646	75/9376	0.967595459236326	PRKACB/ATP1B3/ITPR2/ITPR1/GNAQ	-0.0766419341025293
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/646	29/9376	1.00096081989965	RGS9/CALM3	0.00140961217505703
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/646	93/9376	0.936382702486767	ITGB1/BCL2/PIK3R1/CDK6/POLK/PIK3CB	-0.167713217425355
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/646	47/9376	0.926421184375206	MDH1/ACACA/ACYP2	-0.137555813813414
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/646	63/9376	0.921519484986977	LEF1/WNT4/GSK3B/POLK	-0.17001298515734
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/646	31/9376	0.936382702486767	IMMP1L/SRP9	-0.0965075266848956
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/646	15/9376	0.967595459236326	SLC33A1	-0.0341652932917895
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/646	235/9376	0.926421184375206	DPF3/RPS6KA3/ACTB/PRKACB/SOS1/RPS6KA2/SMARCA2/ARID1B/KRAS/MAPK14/NDUFB3/COX8A/SOS2/SMARCB1/SMARCD1	-0.310731044476004
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/646	49/9376	0.888608074808871	PRKACB/MAOA/RGS9	-0.212654969886924
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/646	97/9376	0.897768982796591	PRKACB/CAMK2G/RPS6KA5/ITPR1/GNAQ/CALM3	-0.27530413673997
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	25/646	388/9376	0.935176023746449	EIF2AK2/PPP3CA/ADAM10/CASP8/WNT4/BRAF/PIK3R1/KRAS/ITPR2/GSK3B/SLC39A11/PPP3CC/PIK3C3/NDUFB3/MAPK8/COX8A/ATG2B/RTN4/ITPR1/ERN1/PIK3CB/GNAQ/ATF6/CALM3/PPP3R1	-0.354743766688996
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/646	82/9376	0.884995846862493	DPYD/NME7/CDA/GMPS/IMPDH1	-0.284520715223994
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/646	16/9376	0.907120743034056	MAOA	-0.101142940288498
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/646	254/9376	0.914263426050072	PRKACB/PPP3CA/STIM2/ATP2B4/STIM1/ITPR2/CAMK2G/ASPH/PTK2B/PPP3CC/ORAI2/ITPR1/CD38/GNAQ/CALM3/PPP3R1	-0.37681894102132
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/646	36/9376	0.806329549363605	AGL/HKDC1	-0.316691167210931
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/646	103/9376	0.845471760497761	PRKACB/ITGAM/PIK3R1/ACTN4/PIK3CB/GNAQ	-0.428954387826999
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/646	18/9376	0.806329549363605	ACACA	-0.223719000586456
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/646	18/9376	0.806329549363605	MANBA	-0.223719000586456
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/646	18/9376	0.806329549363605	LMBRD1	-0.223719000586456
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/646	87/9376	0.83413401658304	ATP1B3/TPM3/ASPH/COX8A/TPM4	-0.422792474230729
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/646	37/9376	0.784536858840264	GFPT1/GLUD1	-0.357205746276821
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/646	37/9376	0.784536858840264	MAOA/COMT	-0.357205746276821
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/646	37/9376	0.784536858840264	APOA1/GNAQ	-0.357205746276821
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/646	38/9376	0.763891152028679	GFPT1/HKDC1	-0.396708860942879
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/646	56/9376	0.777532065457762	CASP8/ITGAM/C3	-0.454201177085346
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/646	191/9376	0.83588089410468	PRKACB/SOS1/HDAC9/MAOA/BRAF/KRAS/HDAC4/HDAC8/SOS2/HDAC2/CALM3	-0.623348646701819
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/646	368/9376	0.867680710728227	ACTB/PPP3CA/PFN1/POM121/BCL2/TNFRSF1B/TBK1/SETX/MAPK14/ATXN2/PPP3CC/PIK3C3/NDUFB3/COX8A/UBQLN1/ATG2B/NUP210/NUP153/ERN1/SPG11/ATF6/PPP3R1	-0.704413475402297
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/646	22/9376	0.659724176752041	MAOA	-0.434648841433647
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	16/646	275/9376	0.844446946242612	PRKACB/PPP3CA/RAC2/PIK3R1/ITPR2/GSK3B/MAPK14/PPP3CC/NDUFB3/NCAM1/MAPK8/FYN/COX8A/ITPR1/PIK3CB/PPP3R1	-0.712188745722407
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	29/646	480/9376	0.876883384932921	PPP3CA/CASP8/BCL2/WNT4/BRAF/TNFRSF1B/KRAS/TBK1/ITPR2/CAMK2G/GSK3B/MAPK14/ATXN2/PPP3CC/PIK3C3/NDUFB3/MAPK8/COX8A/MFN1/ATG2B/HTT/UBE2J1/ITPR1/ERN1/SPG11/GNAQ/ATF6/CALM3/PPP3R1	-0.75324225270119
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/646	23/9376	0.631040516893256	GLUD1	-0.481905522667286
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/646	23/9376	0.631040516893256	ST3GAL3	-0.481905522667286
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/646	23/9376	0.631040516893256	MSH3	-0.481905522667286
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/646	44/9376	0.659724176752041	PRKACB/ARHGDIB	-0.615410415099402
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/646	99/9376	0.733026863057823	ITGAM/CFH/C3/KRT23/ITGAL	-0.726400540792329
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/646	217/9376	0.802613744988658	RPS6KA3/PRKACB/SOS1/RPS6KA2/KPNA1/JAK2/BCL2/PIK3R1/KRAS/CCND3/SOS2/PIK3CB	-0.800234959084564
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/646	100/9376	0.725696594427245	TNFRSF1B/CCR1/TNFRSF10A/IL2RA/CCL8	-0.750145666799254
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/646	100/9376	0.725696594427245	ITGA1/ITGAM/ITGA4/CD38/IL2RA	-0.750145666799254
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	15/646	268/9376	0.812346934060348	PRKACB/NFE2L2/MAOA/ITPR2/CAMK2G/SLC39A11/NDUFB3/MAPK8/COX8A/MFN1/UBE2J1/ITPR1/ERN1/ATF6/CALM3	-0.847825209448091
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/646	66/9376	0.659724176752041	STAT4/SMAD2/GATA3	-0.754610764307783
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/646	86/9376	0.675066599467204	PRKACB/ATP1B3/CAMK2G/GNAQ	-0.823437231427448
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/646	48/9376	0.604747162022704	HIBCH/AUH	-0.746785921949774
NA	NA	hsa03272	Virion - Hepatitis viruses	2/646	48/9376	0.604747162022704	LDLR/PDCD6IP	-0.746785921949774
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/646	28/9376	0.518354710305175	ST3GAL3	-0.69429135326241
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/646	28/9376	0.518354710305175	PCBD1	-0.69429135326241
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/646	28/9376	0.518354710305175	ATP6V1A	-0.69429135326241
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/646	89/9376	0.652311545552579	ITGA1/ITGB1/CD47/ITGA4	-0.896483550979297
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/646	29/9376	0.500480409949824	LIMD1	-0.732841707454631
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/646	52/9376	0.558228149559419	PRKACB/LDLR	-0.868947131805342
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/646	30/9376	0.483797729618163	PLAAT2	-0.770304481826915
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/646	31/9376	0.468191351243384	G6PD	-0.806754442067612
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/646	31/9376	0.468191351243384	MDH1	-0.806754442067612
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/646	149/9376	0.681862571945062	PRKACB/ITPR2/MAPK14/NDUFB3/MAPK8/ITPR1/GNAQ	-1.0648107205833
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/646	32/9376	0.453560371517028	HKDC1	-0.842258760798058
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/646	76/9376	0.572918364021509	APOA1/SLC27A2/ACOX1	-1.01688301850732
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	17/646	323/9376	0.763891152028679	MMP9/SOS1/BCL2/PIK3R1/KRAS/EP300/PIM1/ROCK1/ABL1/CDK6/RPS6KA5/HDAC4/STMN1/SOS2/HDAC2/ZEB1/PIK3CB	-1.17465961668285
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/646	33/9376	0.439816117834694	IDH2	-0.876878011381407
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/646	155/9376	0.655467891740737	ACTB/ITGB1/ITGAM/ATP6V1A/CORO1A/PIK3C3/C3	-1.17652542034691
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/646	59/9376	0.491997691137115	IDH2/G6PD	-1.06475188981787
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/646	61/9376	0.475866619296554	ATP2B4/ATP1B3	-1.11714638088077
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/646	103/9376	0.56364784033184	ATP1B3/CPB1/COL14A1/PRSS3	-1.2112684007167
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/646	38/9376	0.381945576014339	CD38	-1.03845183544261
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/646	63/9376	0.460759742493489	PLAAT2/HPGD	-1.1681606049665
NA	NA	hsa04081	Hormone signaling	10/646	219/9376	0.662736615915292	PRL/PRKACB/PRLR/JAK2/PIK3R1/SMAD4/ADIPOR2/APPL1/PIK3CB/GNAQ	-1.37375542051912
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	15/646	308/9376	0.706847332234329	CASP8/POLR2J/RCOR1/EP300/POLR2J3/PIK3C3/NDUFB3/MAPK8/COX8A/ATG2B/HTT/HDAC2/ITPR1/ERN1/GNAQ	-1.42301090618307
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/646	128/9376	0.566950464396285	PDE7A/NME7/GMPS/ADK/IMPDH1	-1.34187921772913
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/646	41/9376	0.353998338744997	MAOA	-1.12762105744953
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/646	42/9376	0.345569806870116	MAOA	-1.1562422911035
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/646	90/9376	0.483797729618163	PRKACB/LDLR/ATP1B3	-1.33850994019764
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/646	43/9376	0.337533299733602	ACOX1	-1.18435643214815
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/646	45/9376	0.322531819745442	KLRC1	-1.2391555869958
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/646	46/9376	0.315520258446628	PSME4	-1.26588271031389
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/646	50/9376	0.290278637770898	MAOA	-1.36873681736112
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/646	50/9376	0.290278637770898	ITGA4	-1.36873681736112
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/646	54/9376	0.268776516454535	MDH1	-1.46584225418233
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/646	138/9376	0.420693677928837	ATP6V1A/NDUFB3/COX8A/PPA2	-1.86489166387208
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/646	91/9376	0.318987514033954	PDE7A/PRKACB	-1.77574087642277
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/646	95/9376	0.305556460811471	ATP6V1A/ITGAL	-1.85053001423386
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/646	66/9376	0.219908058917347	COMT	-1.72996650267968
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/646	67/9376	0.21662584908276	HKDC1	-1.75045075965756
NA	NA	hsa04382	Cornified envelope formation	7/646	217/9376	0.468191351243384	PPP2R2B/PPP2R5A/S100A11/PPP2R5E/KRT86/KRT23/SPTLC1	-2.15603600288234
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/646	73/9376	0.198820984774588	MAOA	-1.86927957451977
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/646	75/9376	0.193519091847265	IDH2	-1.90745664530079
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/646	79/9376	0.183720656817024	ATP6V1A	-1.98187250149258
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/646	86/9376	0.168766649866801	PRKACB	-2.10648855236647
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/646	89/9376	0.163077886388145	PRKACB	-2.15792873967093
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/646	298/9376	0.438340224821826	PRL/IL1RL1/PRLR/TNFRSF1B/CCR1/TNFRSF18/TNFRSF10A/IL2RA/CCL8	-2.68028601270426
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/646	143/9376	0.202992054385243	ACTN4/C3	-2.61248633407068
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/646	183/9376	0.237933309648277	EFL1/XRN1/NOP56	-2.83194405318225
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/646	154/9376	0.188492621929154	NME7/PANK3	-2.76207234478145
Genetic Information Processing	Translation	hsa03010	Ribosome	4/646	222/9376	0.261512286280088	RPL36AL/RPL28/MRPL44/MRPS10	-3.02906841747563
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/646	243/9376	0.238912459070698	SRSF4/SF3B2/THOC2/SNRPB2	-3.2698346816294
NA	NA	hsa04082	Neuroactive ligand signaling	2/646	199/9376	0.145868662196431	PRKACB/GNAQ	-3.3128029481221
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/646	370/9376	0.274587900594093	PRL/PRLR/NR3C1/PRSS3/TSPO/PGRMC2/C3	-3.87270540026806
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/646	449/9376	0.129300061367883	PRKACB/NCALD/CAMK2G/CALM3	-5.14320331068524